format-version: 1.2
data-version: 1.1.1058
date: 26:02:2010 15:20
saved-by: midori
auto-generated-by: OBO-Edit 2.0
subsetdef: goslim_candida "Candida GO slim"
subsetdef: goslim_generic "Generic GO slim"
subsetdef: goslim_goa "GOA and proteome slim"
subsetdef: goslim_pir "PIR GO slim"
subsetdef: goslim_plant "Plant GO slim"
subsetdef: goslim_pombe "Fission yeast GO slim"
subsetdef: goslim_yeast "Yeast GO slim"
subsetdef: gosubset_prok "Prokaryotic GO subset"
synonymtypedef: systematic_synonym "Systematic synonym" EXACT
default-namespace: gene_ontology
remark: cvs version: $Revision: 1.1058 $

[Term]
id: GO:0000001
name: mitochondrion inheritance
namespace: biological_process
def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764]
synonym: "mitochondrial inheritance" EXACT []
is_a: GO:0048308 ! organelle inheritance
is_a: GO:0048311 ! mitochondrion distribution

[Term]
id: GO:0000002
name: mitochondrial genome maintenance
namespace: biological_process
def: "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw]
is_a: GO:0007005 ! mitochondrion organization

[Term]
id: GO:0000003
name: reproduction
namespace: biological_process
alt_id: GO:0019952
alt_id: GO:0050876
def: "The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism." [GOC:go_curators, GOC:isa_complete, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "reproductive physiological process" EXACT []
xref: Wikipedia:Reproduction
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0000005
name: ribosomal chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function." [GOC:jl, PMID:12150913]
comment: This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function.
is_obsolete: true
consider: GO:0042254
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0000006
name: high affinity zinc uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+(out) = Zn2+(in), probably powered by proton motive force. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.5.1.1]
is_a: GO:0005385 ! zinc ion transmembrane transporter activity

[Term]
id: GO:0000007
name: low-affinity zinc ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005385 ! zinc ion transmembrane transporter activity

[Term]
id: GO:0000008
name: thioredoxin
namespace: molecular_function
alt_id: GO:0000013
def: "OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol." [GOC:kd]
comment: This term was made obsolete because it represents gene products.
is_obsolete: true
consider: GO:0006467
consider: GO:0015036

[Term]
id: GO:0000009
name: alpha-1,6-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,6-linkage." [GOC:mcc, PMID:2644248]
xref: EC:2.4.1.-
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0000010
name: trans-hexaprenyltranstransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-heptaprenyl diphosphate." [EC:2.5.1.30]
subset: gosubset_prok
synonym: "all-trans-heptaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.30]
synonym: "all-trans-hexaprenyl-diphosphate:isopentenyl-diphosphate hexaprenyltranstransferase activity" EXACT [EC:2.5.1.30]
synonym: "heptaprenyl diphosphate synthase activity" EXACT [EC:2.5.1.30]
synonym: "heptaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.30]
synonym: "heptaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.30]
xref: EC:2.5.1.30
xref: MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0000011
name: vacuole inheritance
namespace: biological_process
def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069]
is_a: GO:0007033 ! vacuole organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0000012
name: single strand break repair
namespace: biological_process
def: "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html]
subset: gosubset_prok
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0000014
name: single-stranded DNA specific endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:mah]
synonym: "ssDNA-specific endodeoxyribonuclease activity" EXACT [GOC:mah]
is_a: GO:0004520 ! endodeoxyribonuclease activity

[Term]
id: GO:0000015
name: phosphopyruvate hydratase complex
namespace: cellular_component
def: "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "enolase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0000016
name: lactase activity
namespace: molecular_function
def: "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." [EC:3.2.1.108]
synonym: "lactase-phlorizin hydrolase activity" BROAD [EC:3.2.1.108]
synonym: "lactose galactohydrolase activity" EXACT [EC:3.2.1.108]
xref: EC:3.2.1.108
xref: MetaCyc:LACTASE-RXN
xref: Reactome:20536 "lactase activity"
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0000017
name: alpha-glucoside transport
namespace: biological_process
def: "The directed movement of alpha-glucosides into, out of, within or between cells by means of some external agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0042946 ! glucoside transport

[Term]
id: GO:0000018
name: regulation of DNA recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA recombination, a process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0006310 ! DNA recombination

[Term]
id: GO:0000019
name: regulation of mitotic recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators]
synonym: "regulation of recombination within rDNA repeats" NARROW []
is_a: GO:0000018 ! regulation of DNA recombination
relationship: regulates GO:0006312 ! mitotic recombination

[Term]
id: GO:0000020
name: negative regulation of recombination within rDNA repeats
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it describes a substrate-specific process.
is_obsolete: true
consider: GO:0045950

[Term]
id: GO:0000022
name: mitotic spindle elongation
namespace: biological_process
def: "Lengthening of the distance between poles of the mitotic spindle." [GOC:mah]
synonym: "spindle elongation during mitosis" EXACT []
is_a: GO:0051231 ! spindle elongation
relationship: part_of GO:0007052 ! mitotic spindle organization

[Term]
id: GO:0000023
name: maltose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "malt sugar metabolic process" EXACT []
synonym: "malt sugar metabolism" EXACT []
synonym: "maltose metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process

[Term]
id: GO:0000024
name: maltose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "malt sugar biosynthesis" EXACT []
synonym: "malt sugar biosynthetic process" EXACT []
synonym: "maltose anabolism" EXACT []
synonym: "maltose biosynthesis" EXACT []
synonym: "maltose formation" EXACT []
synonym: "maltose synthesis" EXACT []
is_a: GO:0000023 ! maltose metabolic process
is_a: GO:0046351 ! disaccharide biosynthetic process

[Term]
id: GO:0000025
name: maltose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "malt sugar catabolic process" EXACT []
synonym: "malt sugar catabolism" EXACT []
synonym: "maltose breakdown" EXACT []
synonym: "maltose degradation" EXACT []
synonym: "maltose hydrolysis" NARROW []
xref: MetaCyc:MALTOSECAT-PWY
is_a: GO:0000023 ! maltose metabolic process
is_a: GO:0046352 ! disaccharide catabolic process

[Term]
id: GO:0000026
name: alpha-1,2-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,2-linkage." [GOC:mcc, PMID:10521541]
xref: EC:2.4.1.-
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0000027
name: ribosomal large subunit assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl]
subset: gosubset_prok
is_a: GO:0042257 ! ribosomal subunit assembly
relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis

[Term]
id: GO:0000028
name: ribosomal small subunit assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl]
subset: gosubset_prok
is_a: GO:0042257 ! ribosomal subunit assembly
relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis

[Term]
id: GO:0000030
name: mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
subset: gosubset_prok
xref: EC:2.4.1.-
xref: Reactome:7672 "mannosyltransferase activity"
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0000031
name: mannosylphosphate transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannosylphosphate group from one compound to another." [GOC:jl]
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0000032
name: cell wall mannoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues other than as a moiety of nucleic acid." [GOC:ai]
subset: gosubset_prok
synonym: "cell wall mannoprotein anabolism" EXACT []
synonym: "cell wall mannoprotein biosynthesis" EXACT []
synonym: "cell wall mannoprotein formation" EXACT []
synonym: "cell wall mannoprotein synthesis" EXACT []
is_a: GO:0006057 ! mannoprotein biosynthetic process
is_a: GO:0031506 ! cell wall glycoprotein biosynthetic process

[Term]
id: GO:0000033
name: alpha-1,3-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,3-linkage." [GOC:mcc, PMID:10521541]
xref: EC:2.4.1.-
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0000034
name: adenine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3." [EC:3.5.4.2]
subset: gosubset_prok
synonym: "ADase activity" EXACT [EC:3.5.4.2]
synonym: "adenase activity" EXACT [EC:3.5.4.2]
synonym: "adenine aminase activity" EXACT [EC:3.5.4.2]
synonym: "adenine aminohydrolase activity" EXACT [EC:3.5.4.2]
xref: EC:3.5.4.2
xref: MetaCyc:ADENINE-DEAMINASE-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0000035
name: acyl binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "acyl-CoA or acyl binding" BROAD []
is_a: GO:0005488 ! binding

[Term]
id: GO:0000036
name: acyl carrier activity
namespace: molecular_function
def: "Enables the directed movement of acyl groups into, out of, within or between cells." [ChEBI:22221, GOC:cb]
subset: gosubset_prok
is_a: GO:0022892 ! substrate-specific transporter activity

[Term]
id: GO:0000038
name: very-long-chain fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fatty acids with a chain length of C18 or greater." [GOC:hjd]
subset: gosubset_prok
synonym: "very-long-chain fatty acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0000039
name: plasma membrane long-chain fatty acid transporter
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a gene product and it contains component information.
is_obsolete: true
consider: GO:0005324
consider: GO:0005886

[Term]
id: GO:0000040
name: low-affinity iron ion transport
namespace: biological_process
def: "The directed, low-affinity movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah]
synonym: "low affinity iron ion transport" EXACT []
is_a: GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0000041
name: transition metal ion transport
namespace: biological_process
def: "The directed movement of transition metal ions into, out of, within or between cells by means of some external agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "transition metal transport" EXACT []
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0000042
name: protein targeting to Golgi
namespace: biological_process
def: "The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah]
synonym: "protein-Golgi targeting" EXACT []
is_a: GO:0000301 ! retrograde transport, vesicle recycling within Golgi
is_a: GO:0006605 ! protein targeting
relationship: part_of GO:0034067 ! protein localization in Golgi apparatus

[Term]
id: GO:0000044
name: ascorbate stabilization
namespace: biological_process
def: "OBSOLETE. The reduction of the ascorbate free radical to a stable form." [GOC:ai, GOC:mtg_electron_transport]
comment: This term was made obsolete because it is defined as a function term and is in the process ontology.
synonym: "vitamin C stabilization" EXACT []
is_obsolete: true

[Term]
id: GO:0000045
name: autophagic vacuole assembly
namespace: biological_process
def: "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [PMID:9412464]
synonym: "autophagic vacuole formation" RELATED [GOC:mah]
synonym: "autophagosome biosynthesis" EXACT []
synonym: "autophagosome formation" EXACT []
synonym: "PAS formation" NARROW []
is_a: GO:0007033 ! vacuole organization
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0016236 ! macroautophagy

[Term]
id: GO:0000046
name: autophagic vacuole fusion
namespace: biological_process
def: "The fusion of an autophagic vacuole with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole." [PMID:11099404]
synonym: "fusion of autophagosome with lysosome" NARROW []
is_a: GO:0048284 ! organelle fusion
is_a: GO:0090174 ! organelle membrane fusion
relationship: part_of GO:0016236 ! macroautophagy

[Term]
id: GO:0000047
name: Rieske iron-sulfur protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "Rieske iron-sulphur protein" EXACT []
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0000048
name: peptidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2)." [EC:2.3.2.12, PMID:11433365, PMID:9242921]
synonym: "peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity" EXACT [EC:2.3.2.12]
xref: EC:2.3.2.12
xref: MetaCyc:PEPTIDYLTRANSFERASE-RXN
xref: Reactome:20610 "peptidyltransferase activity"
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0000049
name: tRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with transfer RNA." [GOC:ai]
subset: gosubset_prok
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0000050
name: urea cycle
namespace: biological_process
alt_id: GO:0006594
alt_id: GO:0006871
def: "A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "ornithine cycle" EXACT []
synonym: "urea biosynthesis" EXACT []
synonym: "urea biosynthetic process" EXACT []
xref: Reactome:448514 "Urea synthesis"
xref: Reactome:469644 "Urea synthesis"
xref: Reactome:487356 "Urea synthesis"
xref: Reactome:507307 "Urea synthesis"
xref: Reactome:517321 "Urea synthesis"
xref: Reactome:526204 "Urea synthesis"
xref: Reactome:531090 "Urea synthesis"
xref: Reactome:536463 "Urea synthesis"
xref: Reactome:542167 "Urea synthesis"
xref: Reactome:547526 "Urea synthesis"
xref: Reactome:552118 "Urea synthesis"
xref: Reactome:557710 "Urea synthesis"
xref: Reactome:568325 "Urea synthesis"
xref: Reactome:581527 "Urea synthesis"
xref: Reactome:585841 "Urea synthesis"
xref: Reactome:592414 "Urea synthesis"
xref: Reactome:595298 "Urea synthesis"
xref: Reactome:597272 "Urea synthesis"
xref: Reactome:598078 "Urea synthesis"
xref: Reactome:599613 "Urea synthesis"
xref: Reactome:600554 "Urea synthesis"
xref: Reactome:602417 "Urea synthesis"
xref: Reactome:70635 "Urea synthesis"
xref: Wikipedia:Urea_cycle
is_a: GO:0019627 ! urea metabolic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0000051
name: urea cycle intermediate metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations.
subset: gosubset_prok
synonym: "urea cycle intermediate metabolism" EXACT []
is_obsolete: true

[Term]
id: GO:0000052
name: citrulline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "citrulline metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0006575 ! cellular amino acid derivative metabolic process

[Term]
id: GO:0000053
name: argininosuccinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "argininosuccinate metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0000054
name: ribosomal subunit export from nucleus
namespace: biological_process
def: "The directed movement of a ribosomal subunit from the nucleus into the cytoplasm." [GOC:ai]
synonym: "ribosomal subunit export from cell nucleus" EXACT [GOC:mah]
synonym: "ribosomal subunit export out of nucleus" EXACT [GOC:mah]
synonym: "ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "ribosomal subunit-nucleus export" EXACT [GOC:mah]
synonym: "ribosome export from nucleus" RELATED [GOC:mah, GOC:rb]
is_a: GO:0033753 ! establishment of ribosome localization
is_a: GO:0051168 ! nuclear export
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0000055
name: ribosomal large subunit export from nucleus
namespace: biological_process
alt_id: GO:0000057
def: "The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah]
synonym: "ribosomal large subunit export from cell nucleus" EXACT []
synonym: "ribosomal large subunit export out of nucleus" EXACT []
synonym: "ribosomal large subunit transport from nucleus to cytoplasm" EXACT []
synonym: "ribosomal large subunit-nucleus export" EXACT []
is_a: GO:0000054 ! ribosomal subunit export from nucleus

[Term]
id: GO:0000056
name: ribosomal small subunit export from nucleus
namespace: biological_process
alt_id: GO:0000058
def: "The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah]
synonym: "ribosomal small subunit export from cell nucleus" EXACT []
synonym: "ribosomal small subunit export out of nucleus" EXACT []
synonym: "ribosomal small subunit transport from nucleus to cytoplasm" EXACT []
synonym: "ribosomal small subunit-nucleus export" EXACT []
is_a: GO:0000054 ! ribosomal subunit export from nucleus

[Term]
id: GO:0000059
name: protein import into nucleus, docking
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the nuclear localization signal of a protein with nuclear envelope proteins such as importins." [GOC:isa_complete, PMID:7878057]
synonym: "protein docking during protein import into nucleus" EXACT []
synonym: "protein docking during protein transport from cytoplasm to nucleus" EXACT []
synonym: "protein docking during protein-nucleus import" EXACT []
synonym: "protein transport from cytoplasm to nucleus, docking" EXACT []
synonym: "protein-nucleus import, docking" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0006606 ! protein import into nucleus

[Term]
id: GO:0000060
name: protein import into nucleus, translocation
namespace: biological_process
def: "The vectorial transfer of a protein from the cytoplasm into the nucleus, through the nuclear pore and across the nuclear envelope." [GOC:jl, GOC:vw, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "protein import into cell nucleus, translocation" EXACT []
synonym: "protein translocation during protein import into nucleus" EXACT []
synonym: "protein translocation during protein transport from cytoplasm to nucleus" EXACT []
synonym: "protein translocation during protein-nucleus import" EXACT []
synonym: "protein transport from cytoplasm to nucleus, translocation" EXACT []
synonym: "protein-nucleus import, translocation" EXACT []
is_a: GO:0006886 ! intracellular protein transport
relationship: part_of GO:0006606 ! protein import into nucleus

[Term]
id: GO:0000061
name: protein import into nucleus, substrate release
namespace: biological_process
def: "The disaggregation of a protein complex composed of the nuclear localization sequence and the importin alpha, and importin beta proteins." [PMID:9687515]
synonym: "protein import into cell nucleus, substrate release" EXACT []
synonym: "protein substrate release during protein import into nucleus" EXACT []
synonym: "protein substrate release during protein transport from cytoplasm to nucleus" EXACT []
synonym: "protein substrate release during protein-nucleus import" EXACT []
synonym: "protein transport from cytoplasm to nucleus, substrate release" EXACT []
synonym: "protein-nucleus import, substrate release" EXACT []
is_a: GO:0043624 ! cellular protein complex disassembly
relationship: part_of GO:0006606 ! protein import into nucleus

[Term]
id: GO:0000062
name: acyl-CoA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "acyl-CoA or acyl binding" BROAD []
is_a: GO:0005504 ! fatty acid binding
is_a: GO:0050662 ! coenzyme binding

[Term]
id: GO:0000064
name: L-ornithine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED []
synonym: "L-ornithine transporter activity" BROAD []
xref: Reactome:20635 "L-ornithine transmembrane transporter activity"
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0000066
name: mitochondrial ornithine transport
namespace: biological_process
def: "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a mitochondrion." [GOC:ai]
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0015822 ! ornithine transport

[Term]
id: GO:0000067
name: DNA replication and chromosome cycle
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity.
is_obsolete: true
consider: GO:0006260
consider: GO:0007059
consider: GO:0051276

[Term]
id: GO:0000070
name: mitotic sister chromatid segregation
namespace: biological_process
alt_id: GO:0016359
def: "The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai]
synonym: "mitotic chromosome segregation" EXACT []
synonym: "mitotic sister-chromatid adhesion release" NARROW []
is_a: GO:0000819 ! sister chromatid segregation
relationship: part_of GO:0007067 ! mitosis

[Term]
id: GO:0000072
name: M phase specific microtubule process
namespace: biological_process
def: "A microtubule-based process that occurs only during M phase of the cell cycle." [GOC:mah]
synonym: "M-phase specific microtubule process" EXACT []
is_a: GO:0007017 ! microtubule-based process
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0000073
name: spindle pole body separation
namespace: biological_process
alt_id: GO:0030475
def: "A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble." [GOC:sgd_curators]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051300 ! spindle pole body organization

[Term]
id: GO:0000075
name: cell cycle checkpoint
namespace: biological_process
def: "The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage." [GOC:mah, ISBN:0815316194]
xref: Reactome:448698 "Cell Cycle Checkpoints"
xref: Reactome:470051 "Cell Cycle Checkpoints"
xref: Reactome:487514 "Cell Cycle Checkpoints"
xref: Reactome:507475 "Cell Cycle Checkpoints"
xref: Reactome:517643 "Cell Cycle Checkpoints"
xref: Reactome:526670 "Cell Cycle Checkpoints"
xref: Reactome:531431 "Cell Cycle Checkpoints"
xref: Reactome:536803 "Cell Cycle Checkpoints"
xref: Reactome:542562 "Cell Cycle Checkpoints"
xref: Reactome:547738 "Cell Cycle Checkpoints"
xref: Reactome:552308 "Cell Cycle Checkpoints"
xref: Reactome:558049 "Cell Cycle Checkpoints"
xref: Reactome:568546 "Cell Cycle Checkpoints"
xref: Reactome:581757 "Cell Cycle Checkpoints"
xref: Reactome:585987 "Cell Cycle Checkpoints"
xref: Reactome:592670 "Cell Cycle Checkpoints"
xref: Reactome:69620 "Cell Cycle Checkpoints"
xref: Wikipedia:Cell_cycle_checkpoint
is_a: GO:0051726 ! regulation of cell cycle

[Term]
id: GO:0000076
name: DNA replication checkpoint
namespace: biological_process
def: "A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:rn, PMID:11728327, PMID:12537518]
is_a: GO:0031570 ! DNA integrity checkpoint
is_a: GO:0032297 ! negative regulation of DNA replication initiation

[Term]
id: GO:0000077
name: DNA damage checkpoint
namespace: biological_process
def: "A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds." [PMID:11891124]
synonym: "DNA damage response, signal transduction resulting in cell cycle arrest" NARROW []
xref: Wikipedia:DNA_damage_checkpoint
xref: Wikipedia:Postreplication_checkpoint
is_a: GO:0031570 ! DNA integrity checkpoint
is_a: GO:0042770 ! DNA damage response, signal transduction

[Term]
id: GO:0000078
name: cell morphogenesis checkpoint
namespace: biological_process
def: "A cell cycle checkpoint observed when aspects of polarity control are defective, which maintains coordination between the process of cellular morphogenesis and the nuclear events of the cell cycle. For example, in budding yeast cell-cycle delay or arrest is induced when aspects of bud formation are defective." [GOC:vw, PMID:14644188]
is_a: GO:0007093 ! mitotic cell cycle checkpoint
relationship: part_of GO:0000902 ! cell morphogenesis

[Term]
id: GO:0000079
name: regulation of cyclin-dependent protein kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators]
synonym: "regulation of CDK activity" EXACT []
is_a: GO:0045859 ! regulation of protein kinase activity
is_a: GO:0051726 ! regulation of cell cycle

[Term]
id: GO:0000080
name: G1 phase of mitotic cell cycle
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through G1 phase, one of two 'gap' phases in the mitotic cell cycle; G1 is the interval between the completion of mitosis and the beginning of DNA synthesis." [GOC:dph, GOC:mah, ISBN:0815316194]
xref: Reactome:448997 "G1 Phase"
xref: Reactome:470110 "G1 Phase"
xref: Reactome:487807 "G1 Phase"
xref: Reactome:507769 "G1 Phase"
xref: Reactome:69236 "G1 Phase"
is_a: GO:0051318 ! G1 phase
relationship: part_of GO:0051329 ! interphase of mitotic cell cycle

[Term]
id: GO:0000082
name: G1/S transition of mitotic cell cycle
namespace: biological_process
def: "Progression from G1 phase to S phase of the mitotic cell cycle." [GOC:mah]
xref: Reactome:448676 "G1/S Transition"
xref: Reactome:469799 "G1/S Transition"
xref: Reactome:487498 "G1/S Transition"
xref: Reactome:507453 "G1/S Transition"
xref: Reactome:517451 "G1/S Transition"
xref: Reactome:526325 "G1/S Transition"
xref: Reactome:531164 "G1/S Transition"
xref: Reactome:536539 "G1/S Transition"
xref: Reactome:542260 "G1/S Transition"
xref: Reactome:547604 "G1/S Transition"
xref: Reactome:552212 "G1/S Transition"
xref: Reactome:557802 "G1/S Transition"
xref: Reactome:568415 "G1/S Transition"
xref: Reactome:581617 "G1/S Transition"
xref: Reactome:585797 "G1/S Transition"
xref: Reactome:592514 "G1/S Transition"
xref: Reactome:595353 "G1/S Transition"
xref: Reactome:597329 "G1/S Transition"
xref: Reactome:598133 "G1/S Transition"
xref: Reactome:599680 "G1/S Transition"
xref: Reactome:602494 "G1/S Transition"
xref: Reactome:69206 "G1/S Transition"
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051329 ! interphase of mitotic cell cycle

[Term]
id: GO:0000083
name: regulation of transcription involved in G1/S-phase of mitotic cell cycle
namespace: biological_process
def: "Any process that regulates transcription such that the target genes are transcribed as part of the G1/S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "G1/S-specific transcription in mitotic cell cycle" RELATED []
synonym: "regulation of transcription from RNA polymerase II promoter of G1/S-phase of mitotic cell cycle" RELATED []
xref: Reactome:69205 "G1/S-Specific Transcription"
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle

[Term]
id: GO:0000084
name: S phase of mitotic cell cycle
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place." [GOC:dph, GOC:mah, ISBN:0815316194]
xref: Reactome:448833 "S Phase"
xref: Reactome:469949 "S Phase"
xref: Reactome:487657 "S Phase"
xref: Reactome:507692 "S Phase"
xref: Reactome:517575 "S Phase"
xref: Reactome:526441 "S Phase"
xref: Reactome:531288 "S Phase"
xref: Reactome:536664 "S Phase"
xref: Reactome:542397 "S Phase"
xref: Reactome:547746 "S Phase"
xref: Reactome:552316 "S Phase"
xref: Reactome:558038 "S Phase"
xref: Reactome:568554 "S Phase"
xref: Reactome:581765 "S Phase"
xref: Reactome:585890 "S Phase"
xref: Reactome:592678 "S Phase"
xref: Reactome:595526 "S Phase"
xref: Reactome:597425 "S Phase"
xref: Reactome:598197 "S Phase"
xref: Reactome:600669 "S Phase"
xref: Reactome:602578 "S Phase"
xref: Reactome:69242 "S Phase"
is_a: GO:0051320 ! S phase
relationship: part_of GO:0051329 ! interphase of mitotic cell cycle

[Term]
id: GO:0000085
name: G2 phase of mitotic cell cycle
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through G2 phase, one of two 'gap' phases in the mitotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of mitosis." [GOC:dph, GOC:mah, ISBN:0815316194]
xref: Reactome:449248 "G2 Phase"
xref: Reactome:470367 "G2 Phase"
xref: Reactome:488046 "G2 Phase"
xref: Reactome:508005 "G2 Phase"
xref: Reactome:517870 "G2 Phase"
xref: Reactome:526697 "G2 Phase"
xref: Reactome:552502 "G2 Phase"
xref: Reactome:558128 "G2 Phase"
xref: Reactome:568757 "G2 Phase"
xref: Reactome:581961 "G2 Phase"
xref: Reactome:592866 "G2 Phase"
xref: Reactome:68911 "G2 Phase"
is_a: GO:0051319 ! G2 phase
relationship: part_of GO:0051329 ! interphase of mitotic cell cycle

[Term]
id: GO:0000086
name: G2/M transition of mitotic cell cycle
namespace: biological_process
def: "Progression from G2 phase to M phase of the mitotic cell cycle." [GOC:mah]
xref: Reactome:448692 "G2/M Transition"
xref: Reactome:469817 "G2/M Transition"
xref: Reactome:487681 "G2/M Transition"
xref: Reactome:507716 "G2/M Transition"
xref: Reactome:517649 "G2/M Transition"
xref: Reactome:526485 "G2/M Transition"
xref: Reactome:531286 "G2/M Transition"
xref: Reactome:536662 "G2/M Transition"
xref: Reactome:542395 "G2/M Transition"
xref: Reactome:547744 "G2/M Transition"
xref: Reactome:552314 "G2/M Transition"
xref: Reactome:558036 "G2/M Transition"
xref: Reactome:568552 "G2/M Transition"
xref: Reactome:581763 "G2/M Transition"
xref: Reactome:585915 "G2/M Transition"
xref: Reactome:592676 "G2/M Transition"
xref: Reactome:69275 "G2/M Transition"
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051329 ! interphase of mitotic cell cycle

[Term]
id: GO:0000087
name: M phase of mitotic cell cycle
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place." [GOC:dph, GOC:mah, ISBN:0815316194]
synonym: "M-phase of mitotic cell cycle" EXACT []
xref: Reactome:448731 "M Phase"
xref: Reactome:469853 "M Phase"
xref: Reactome:487547 "M Phase"
xref: Reactome:507504 "M Phase"
xref: Reactome:517490 "M Phase"
xref: Reactome:526359 "M Phase"
xref: Reactome:531189 "M Phase"
xref: Reactome:536559 "M Phase"
xref: Reactome:542285 "M Phase"
xref: Reactome:547626 "M Phase"
xref: Reactome:552505 "M Phase"
xref: Reactome:557820 "M Phase"
xref: Reactome:586013 "M Phase"
xref: Reactome:592536 "M Phase"
xref: Reactome:68886 "M Phase"
is_a: GO:0000279 ! M phase
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0000088
name: mitotic prophase
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through prophase, the initial stage of mitosis in which the chromosomes are condensed but are not yet attached to a mitotic spindle." [GOC:dph, GOC:mah, ISBN:0815316194]
xref: Reactome:448730 "Mitotic Prophase"
xref: Reactome:469852 "Mitotic Prophase"
xref: Reactome:487546 "Mitotic Prophase"
xref: Reactome:507503 "Mitotic Prophase"
xref: Reactome:517489 "Mitotic Prophase"
xref: Reactome:526358 "Mitotic Prophase"
xref: Reactome:531188 "Mitotic Prophase"
xref: Reactome:536558 "Mitotic Prophase"
xref: Reactome:542284 "Mitotic Prophase"
xref: Reactome:547625 "Mitotic Prophase"
xref: Reactome:557819 "Mitotic Prophase"
xref: Reactome:592535 "Mitotic Prophase"
xref: Reactome:68875 "Mitotic Prophase"
is_a: GO:0051324 ! prophase
relationship: part_of GO:0007067 ! mitosis

[Term]
id: GO:0000089
name: mitotic metaphase
namespace: biological_process
def: "Progression through metaphase, the stage of mitosis at which chromosomes are firmly attached to the mitotic spindle at its equator but have not yet segregated to opposite poles." [ISBN:0815316194]
xref: Reactome:68879 "Mitotic Metaphase"
is_a: GO:0051323 ! metaphase
relationship: part_of GO:0007067 ! mitosis

[Term]
id: GO:0000090
name: mitotic anaphase
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other." [GOC:dph, ISBN:0815316194]
xref: Reactome:68882 "Mitotic Anaphase"
is_a: GO:0051322 ! anaphase
relationship: part_of GO:0007067 ! mitosis

[Term]
id: GO:0000091
name: mitotic anaphase A
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through anaphase A, the part of mitotic anaphase in which the kinetochore microtubules shorten as chromosomes move toward the spindle poles." [GOC:dph, GOC:mah, ISBN:0815316194]
is_a: GO:0000090 ! mitotic anaphase

[Term]
id: GO:0000092
name: mitotic anaphase B
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through anaphase B, the part of mitotic anaphase in which the polar microtubules elongate and the two poles of the spindle move farther apart." [GOC:dph, GOC:mah, ISBN:0815316194]
is_a: GO:0000090 ! mitotic anaphase

[Term]
id: GO:0000093
name: mitotic telophase
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through telophase, the last of the stages of mitosis; in the canonical cell cycle, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:dph, GOC:mah, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0051326 ! telophase
relationship: part_of GO:0007067 ! mitosis

[Term]
id: GO:0000094
name: septin assembly and septum formation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was not defined and the string name implied two separate processes.
is_obsolete: true
consider: GO:0000917
consider: GO:0000918
consider: GO:0000921

[Term]
id: GO:0000095
name: S-adenosylmethionine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015177
def: "Catalysis of the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai]
synonym: "S-adenosyl methionine permease activity" EXACT []
synonym: "S-adenosyl methionine transporter activity" EXACT []
synonym: "S-adenosylmethionine permease activity" EXACT []
synonym: "S-adenosylmethionine transporter activity" BROAD []
is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity
is_a: GO:0051184 ! cofactor transporter activity

[Term]
id: GO:0000096
name: sulfur amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai]
subset: gosubset_prok
synonym: "sulfur amino acid metabolism" EXACT []
synonym: "sulphur amino acid metabolic process" EXACT []
synonym: "sulphur amino acid metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0000097
name: sulfur amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai]
subset: gosubset_prok
synonym: "sulfur amino acid anabolism" EXACT []
synonym: "sulfur amino acid biosynthesis" EXACT []
synonym: "sulfur amino acid formation" EXACT []
synonym: "sulfur amino acid synthesis" EXACT []
synonym: "sulphur amino acid biosynthesis" EXACT []
synonym: "sulphur amino acid biosynthetic process" EXACT []
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0000098
name: sulfur amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai]
subset: gosubset_prok
synonym: "sulfur amino acid breakdown" EXACT []
synonym: "sulfur amino acid catabolism" EXACT []
synonym: "sulfur amino acid degradation" EXACT []
synonym: "sulphur amino acid catabolic process" EXACT []
synonym: "sulphur amino acid catabolism" EXACT []
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0000099
name: sulfur amino acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "sulfur amino acid transporter activity" BROAD []
synonym: "sulphur amino acid transmembrane transporter activity" EXACT []
synonym: "sulphur amino acid transporter activity" BROAD []
is_a: GO:0015171 ! amino acid transmembrane transporter activity

[Term]
id: GO:0000100
name: S-methylmethionine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015178
def: "Catalysis of the transfer of S-methylmethionine from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "S-methylmethionine permease activity" EXACT []
synonym: "S-methylmethionine transporter activity" BROAD []
is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity

[Term]
id: GO:0000101
name: sulfur amino acid transport
namespace: biological_process
def: "The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "sulphur amino acid transport" EXACT []
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0000102
name: L-methionine secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
synonym: "L-methionine porter activity" RELATED []
is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity
is_a: GO:0015191 ! L-methionine transmembrane transporter activity

[Term]
id: GO:0000103
name: sulfate assimilation
namespace: biological_process
alt_id: GO:0019378
def: "The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GOC:jl]
subset: gosubset_prok
synonym: "sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW []
synonym: "sulphate assimilation" EXACT []
synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW []
is_a: GO:0006791 ! sulfur utilization

[Term]
id: GO:0000104
name: succinate dehydrogenase activity
namespace: molecular_function
alt_id: GO:0019739
def: "Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor." [EC:1.3.99.1, GOC:kd]
subset: gosubset_prok
synonym: "fumarate dehydrogenase activity" EXACT [EC:1.3.99.1]
synonym: "fumarate reductase activity" EXACT [EC:1.3.99.1]
synonym: "fumaric hydrogenase activity" EXACT [EC:1.3.99.1]
synonym: "succinate oxidoreductase activity" EXACT [EC:1.3.99.1]
synonym: "succinate:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.1]
synonym: "succinate:acceptor oxidoreductase activity" EXACT [EC:1.3.99.1]
synonym: "succinic acid dehydrogenase activity" EXACT [EC:1.3.99.1]
synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.99.1]
synonym: "succinodehydrogenase activity" EXACT [EC:1.3.99.1]
synonym: "succinyl dehydrogenase activity" EXACT [EC:1.3.99.1]
xref: EC:1.3.99.1
xref: MetaCyc:SUCC-FUM-OXRED-RXN
xref: Reactome:21566 "succinate dehydrogenase activity"
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0000105
name: histidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine anabolism" EXACT []
synonym: "histidine biosynthesis" EXACT []
synonym: "histidine formation" EXACT []
synonym: "histidine synthesis" EXACT []
xref: MetaCyc:HISTSYN-PWY
is_a: GO:0006547 ! histidine metabolic process
is_a: GO:0009076 ! histidine family amino acid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process

[Term]
id: GO:0000107
name: imidazoleglycerol-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + AICAR + L-glutamate." [MetaCyc:GLUTAMIDOTRANS-RXN]
subset: gosubset_prok
synonym: "glutamine amidotransferase:cyclase activity" BROAD []
synonym: "imidazole glycerol phosphate synthase activity" EXACT []
synonym: "imidazole-glycerol-phosphate synthase activity" RELATED []
synonym: "imidazoleglycerol phosphate synthase activity" EXACT []
xref: EC:2.4.2.-
xref: MetaCyc:GLUTAMIDOTRANS-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0000108
name: repairosome
namespace: cellular_component
def: "A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage." [PMID:10681587, PMID:9852079]
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000109
name: nucleotide-excision repair complex
namespace: cellular_component
def: "Any complex formed of proteins that act in nucleotide-excision repair." [PMID:10915862]
comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex.
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000110
name: nucleotide-excision repair factor 1 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively." [PMID:10915862]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "NEF1 complex" EXACT []
synonym: "XPA-ERCC1-ERCC4 complex" EXACT [PMID:8197175]
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000111
name: nucleotide-excision repair factor 2 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p." [PMID:10915862]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "NEF2 complex" EXACT []
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000112
name: nucleotide-excision repair factor 3 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (Core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. Note that Ssl2p is also called Rad25p)." [PMID:10915862, PMID:14500720, PMID:7813015]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "NEF3 complex" EXACT []
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000113
name: nucleotide-excision repair factor 4 complex
namespace: cellular_component
def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p." [PMID:10915862]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "NEF4 complex" EXACT []
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0000114
name: regulation of transcription involved in G1 phase of mitotic cell cycle
namespace: biological_process
def: "Any process that regulates transcription such that the target genes are transcribed as part of the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "G1-specific transcription in mitotic cell cycle" RELATED []
synonym: "regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle" EXACT []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0000080 ! G1 phase of mitotic cell cycle

[Term]
id: GO:0000115
name: regulation of transcription involved in S-phase of mitotic cell cycle
namespace: biological_process
def: "A cell cycle process that regulates transcription such that the target genes are transcribed as part of the S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle" RELATED []
synonym: "S-phase-specific transcription in mitotic cell cycle" RELATED []
synonym: "S-specific transcription in mitotic cell cycle" EXACT []
xref: Reactome:69241 "S-specific transcription in mitotic cell cycle"
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0000084 ! S phase of mitotic cell cycle

[Term]
id: GO:0000116
name: regulation of transcription involved in G2-phase of mitotic cell cycle
namespace: biological_process
def: "Any process that regulates transcription such that the target genes are transcribed as part of the G2 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "G2-specific transcription in mitotic cell cycle" RELATED []
synonym: "regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle" RELATED []
xref: Reactome:69957 "G2-specific transcription in mitotic cell cycle"
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0000085 ! G2 phase of mitotic cell cycle

[Term]
id: GO:0000117
name: regulation of transcription involved in G2/M-phase of mitotic cell cycle
namespace: biological_process
def: "Any process that regulates transcription such that the target genes are transcribed as part of the G2/M phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "G2/M-specific transcription in mitotic cell cycle" RELATED []
synonym: "regulation of transcription from RNA polymerase II promoter during G2/M-phase of mitotic cell cycle" RELATED []
xref: Reactome:69274 "G2/M-specific transcription in mitotic cell cycle"
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle

[Term]
id: GO:0000118
name: histone deacetylase complex
namespace: cellular_component
def: "A protein complex that possesses histone deacetylase activity." [GOC:mah]
comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'.
synonym: "HDAC complex" EXACT []
is_a: GO:0016585 ! chromatin remodeling complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0000120
name: RNA polymerase I transcription factor complex
namespace: cellular_component
def: "A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I." [GOC:mah]
is_a: GO:0005667 ! transcription factor complex
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0000121
name: glycerol-1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol 1-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.21]
synonym: "alpha-glycerol phosphatase activity" EXACT [EC:3.1.3.21]
synonym: "alpha-glycerophosphatase activity" EXACT [EC:3.1.3.21]
synonym: "glycerol 3-phosphatase activity" EXACT [EC:3.1.3.21]
synonym: "glycerol 3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21]
synonym: "glycerol-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21]
synonym: "glycerol-3-phosphate phosphatase activity" EXACT [EC:3.1.3.21]
xref: EC:3.1.3.21
xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0000122
name: negative regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators]
synonym: "down regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter" NARROW []
synonym: "negative regulation of transcription from Pol II promoter" EXACT []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent
relationship: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter

[Term]
id: GO:0000123
name: histone acetyltransferase complex
namespace: cellular_component
def: "A protein complex that possesses histone acetyltransferase activity." [GOC:mah]
comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'.
synonym: "histone acetylase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0000124
name: SAGA complex
namespace: cellular_component
def: "A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012]
synonym: "Spt-Ada-Gcn5-acetyltransferase complex" EXACT []
is_a: GO:0070461 ! SAGA-type complex

[Term]
id: GO:0000125
name: PCAF complex
namespace: cellular_component
def: "A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs." [PMID:10637607]
comment: See also the cellular component term 'SAGA complex ; GO:0000124'.
synonym: "PCAF histone acetylase-associated complex" EXACT []
is_a: GO:0070461 ! SAGA-type complex

[Term]
id: GO:0000126
name: transcription factor TFIIIB complex
namespace: cellular_component
def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF." [GOC:mah, PMID:11433012]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0000127
name: transcription factor TFIIIC complex
namespace: cellular_component
def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species." [GOC:mah, PMID:11433012]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0000128
name: flocculation
namespace: biological_process
def: "The non-sexual aggregation of single-celled organisms." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Flocculation
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0000131
name: incipient cellular bud site
namespace: cellular_component
def: "The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence." [GOC:clt]
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000132
name: establishment of mitotic spindle orientation
namespace: biological_process
alt_id: GO:0030607
alt_id: GO:0030609
def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems]
synonym: "establishment of spindle orientation during mitosis" EXACT []
synonym: "mitotic spindle orientation" EXACT []
synonym: "orienting of mitotic spindle" EXACT []
is_a: GO:0040001 ! establishment of mitotic spindle localization
is_a: GO:0051294 ! establishment of spindle orientation

[Term]
id: GO:0000133
name: polarisome
namespace: cellular_component
def: "Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p." [PMID:14734532, PMID:14998522, PMID:9632790]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030427 ! site of polarized growth

[Term]
id: GO:0000135
name: septin checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic CDK. In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed." [PMID:9925642]
is_a: GO:0031565 ! cytokinesis checkpoint

[Term]
id: GO:0000136
name: alpha-1,6-mannosyltransferase complex
namespace: cellular_component
def: "A large, multiprotein complex with alpha-1,6 mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins." [GOC:mcc, PMID:10037752, PMID:11095735]
is_a: GO:0031501 ! mannosyltransferase complex
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0000137 ! Golgi cis cisterna

[Term]
id: GO:0000137
name: Golgi cis cisterna
namespace: cellular_component
def: "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194]
is_a: GO:0031985 ! Golgi cisterna

[Term]
id: GO:0000138
name: Golgi trans cisterna
namespace: cellular_component
def: "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194]
synonym: "late Golgi" RELATED [GOC:mah]
is_a: GO:0031985 ! Golgi cisterna

[Term]
id: GO:0000139
name: Golgi membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0000140
name: acylglycerone-phosphate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-palmitoylglycerol 3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H+." [EC:1.1.1.101]
synonym: "1-acyldihydroxyacetone-phosphate reductase activity" EXACT []
synonym: "1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.101]
synonym: "acyldihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101]
synonym: "palmitoyl dihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101]
synonym: "palmitoyl-dihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101]
synonym: "palmitoyldihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101]
xref: EC:1.1.1.101
xref: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN
xref: Reactome:21659 "acylglycerone-phosphate reductase activity"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000142
name: cellular bud neck contractile ring
namespace: cellular_component
def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, PMID:16009555]
synonym: "neck ring" EXACT []
is_a: GO:0005826 ! actomyosin contractile ring
relationship: part_of GO:0005935 ! cellular bud neck

[Term]
id: GO:0000144
name: cellular bud neck septin ring
namespace: cellular_component
def: "A ring-shaped structure that forms at the site of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange." [GOC:krc, PMID:16009555]
is_a: GO:0000399 ! cellular bud neck septin structure
is_a: GO:0005940 ! septin ring
is_a: GO:0032161 ! cleavage apparatus septin structure

[Term]
id: GO:0000145
name: exocyst
namespace: cellular_component
def: "A protein complex peripherally associated with the plasma membrane that determines where secretory vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152]
synonym: "Sec6/8 complex" EXACT []
xref: Wikipedia:Exocyst
is_a: GO:0043234 ! protein complex
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0000146
name: microfilament motor activity
namespace: molecular_function
def: "Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
synonym: "actin filament motor activity" EXACT [GOC:dph]
synonym: "actin-filament motor activity" EXACT []
synonym: "muscle motor activity" NARROW []
synonym: "myosin ATPase activity" RELATED []
xref: Reactome:10657 "microfilament motor activity"
is_a: GO:0003774 ! motor activity

[Term]
id: GO:0000147
name: actin cortical patch assembly
namespace: biological_process
def: "Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells." [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0030866 ! cortical actin cytoskeleton organization

[Term]
id: GO:0000148
name: 1,3-beta-glucan synthase complex
namespace: cellular_component
def: "A protein complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain." [EC:2.4.1.34]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0000149
name: SNARE binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621]
synonym: "SNAP receptor binding" EXACT []
xref: Reactome:15373 "SNARE binding"
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0000150
name: recombinase activity
namespace: molecular_function
def: "Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh]
comment: Consider also annotating to the molecular function terms 'double-stranded DNA binding ; GO:0003690' and 'single-stranded DNA binding ; GO:0003697'. Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'.
subset: gosubset_prok
synonym: "strand transferase" NARROW []
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0000151
name: ubiquitin ligase complex
namespace: cellular_component
def: "A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000152
name: nuclear ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex found in the nucleus." [GOC:mah]
is_a: GO:0000151 ! ubiquitin ligase complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000153
name: cytoplasmic ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex found in the cytoplasm." [GOC:mah]
is_a: GO:0000151 ! ubiquitin ligase complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000154
name: rRNA modification
namespace: biological_process
alt_id: GO:0016548
def: "The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]
comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'.
subset: gosubset_prok
synonym: "rRNA editing" EXACT []
is_a: GO:0006364 ! rRNA processing
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0000155
name: two-component sensor activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell." [GOC:mah]
subset: gosubset_prok
synonym: "two-component sensor molecule" NARROW []
synonym: "two-component system sensor activity " EXACT []
xref: EC:2.7.3.-
is_a: GO:0004673 ! protein histidine kinase activity
is_a: GO:0004871 ! signal transducer activity

[Term]
id: GO:0000156
name: two-component response regulator activity
namespace: molecular_function
def: "Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell." [GOC:mah]
subset: gosubset_prok
is_a: GO:0004871 ! signal transducer activity
is_a: GO:0030528 ! transcription regulator activity

[Term]
id: GO:0000159
name: protein phosphatase type 2A complex
namespace: cellular_component
def: "A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000160
name: two-component signal transduction system (phosphorelay)
namespace: biological_process
def: "A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038]
subset: gosubset_prok
synonym: "histidyl-aspartyl phosphorelay" EXACT []
is_a: GO:0023060 ! signal transmission

[Term]
id: GO:0000161
name: MAPKKK cascade involved in osmosensory signaling pathway
namespace: biological_process
def: "MAPKKK cascade involved in signal transduction in response to change in osmotic conditions." [PMID:9561267]
synonym: "MAPKKK cascade during osmolarity sensing" EXACT []
synonym: "osmolarity sensing, MAPKKK cascade" EXACT []
is_a: GO:0000165 ! MAPKKK cascade
is_a: GO:0023034 ! intracellular signaling pathway
relationship: part_of GO:0007231 ! osmosensory signaling pathway

[Term]
id: GO:0000162
name: tryptophan biosynthetic process
namespace: biological_process
alt_id: GO:0009096
def: "The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", MetaCyc:TRPSYN-PWY]
subset: gosubset_prok
synonym: "aromatic amino acid family biosynthetic process, anthranilate pathway" EXACT []
synonym: "tryptophan anabolism" EXACT []
synonym: "tryptophan biosynthesis" EXACT []
synonym: "tryptophan formation" EXACT []
synonym: "tryptophan synthesis" EXACT []
xref: MetaCyc:TRPSYN-PWY
is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0009073 ! aromatic amino acid family biosynthetic process
is_a: GO:0046219 ! indolalkylamine biosynthetic process

[Term]
id: GO:0000164
name: protein phosphatase type 1 complex
namespace: cellular_component
def: "A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity." [GOC:mah, GOC:ssd]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000165
name: MAPKKK cascade
namespace: biological_process
def: "A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways." [GOC:mah, PMID:9561267]
synonym: "ERK/MAPK cascade" EXACT []
synonym: "MAP kinase cascade" EXACT []
synonym: "MAP kinase kinase kinase cascade" EXACT []
synonym: "MAPK cascade" EXACT []
synonym: "MAPK signaling" RELATED []
synonym: "MAPK signalling" RELATED []
synonym: "MAPKKK cascade during sporulation" NARROW []
xref: Reactome:109869 "MAP kinase cascade"
xref: Reactome:448645 "MAP kinase cascade"
xref: Reactome:469773 "MAP kinase cascade"
xref: Reactome:487467 "MAP kinase cascade"
xref: Reactome:507427 "MAP kinase cascade"
xref: Reactome:517430 "MAP kinase cascade"
xref: Reactome:526304 "MAP kinase cascade"
xref: Reactome:531355 "MAP kinase cascade"
xref: Reactome:536731 "MAP kinase cascade"
xref: Reactome:542480 "MAP kinase cascade"
xref: Reactome:547807 "MAP kinase cascade"
xref: Reactome:552371 "MAP kinase cascade"
xref: Reactome:557980 "MAP kinase cascade"
xref: Reactome:568627 "MAP kinase cascade"
xref: Reactome:581831 "MAP kinase cascade"
xref: Reactome:592741 "MAP kinase cascade"
xref: Reactome:595472 "MAP kinase cascade"
xref: Wikipedia:MAPK_cascade
xref: Wikipedia:Mitogen-activated_protein_kinase
is_a: GO:0007243 ! protein kinase cascade

[Term]
id: GO:0000166
name: nucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety." [GOC:mah, ISBN:0198547684]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0000167
name: activation of MAPKKK activity involved in osmosensory signaling pathway
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during osmolarity sensing." [PMID:9561267]
synonym: "activation of MAP kinase kinase kinase activity during osmolarity sensing" EXACT []
synonym: "activation of MAPKKK activity during osmolarity sensing" EXACT []
synonym: "osmolarity sensing, activation of MAP kinase kinase kinase activity" EXACT []
synonym: "osmolarity sensing, activation of MAPKKK activity" EXACT []
is_a: GO:0000185 ! activation of MAPKKK activity
relationship: part_of GO:0000161 ! MAPKKK cascade involved in osmosensory signaling pathway

[Term]
id: GO:0000168
name: activation of MAPKK activity involved in osmosensory signaling pathway
namespace: biological_process
alt_id: GO:0007233
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase during osmolarity sensing." [PMID:9561267]
synonym: "activation of MAP kinase kinase activity during osmolarity sensing" EXACT []
synonym: "activation of MAPKK activity during osmolarity sensing" EXACT []
synonym: "activation of Pbs2 kinase" NARROW []
synonym: "osmolarity sensing, activation of MAP kinase kinase activity" EXACT []
synonym: "osmolarity sensing, activation of MAPKK activity" EXACT []
is_a: GO:0000186 ! activation of MAPKK activity
relationship: part_of GO:0000161 ! MAPKKK cascade involved in osmosensory signaling pathway

[Term]
id: GO:0000169
name: activation of MAPK activity involved in osmosensory signaling pathway
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing." [PMID:9561267]
synonym: "activation of MAPK activity during osmolarity sensing" EXACT []
synonym: "osmolarity sensing, activation of MAPK activity" EXACT []
is_a: GO:0000187 ! activation of MAPK activity
relationship: part_of GO:0000161 ! MAPKKK cascade involved in osmosensory signaling pathway

[Term]
id: GO:0000170
name: sphingosine hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of sphingolipid long chain bases." [PMID:9556590]
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0000171
name: ribonuclease MRP activity
namespace: molecular_function
def: "Catalysis of the site-specific cleavage of RNA by a catalytic RNA_mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA." [PMID:17881380]
synonym: "RNase MRP" EXACT []
xref: Wikipedia:RNase_MRP
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0000172
name: ribonuclease MRP complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication." [GOC:sgd_curators, PMID:10690410, PMID:14729943, PMID:7510714]
synonym: "ribonuclease mitochondrial RNA processing complex" EXACT []
synonym: "RNase MRP complex" EXACT []
is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex

[Term]
id: GO:0000173
name: inactivation of MAPK activity involved in osmosensory signaling pathway
namespace: biological_process
def: "Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing." [PMID:9561267]
synonym: "inactivation of MAPK activity during osmolarity sensing" EXACT []
synonym: "osmolarity sensing, inactivation of MAPK" EXACT []
synonym: "osmolarity sensing, termination of MAPK activity" EXACT []
synonym: "termination of MAPK activity during osmolarity sensing" EXACT []
is_a: GO:0000188 ! inactivation of MAPK activity
is_a: GO:0023034 ! intracellular signaling pathway
relationship: part_of GO:0000161 ! MAPKKK cascade involved in osmosensory signaling pathway

[Term]
id: GO:0000174
name: inactivation of MAPK (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0000175
name: 3'-5'-exoribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "3'-5' exoribonuclease activity" EXACT []
xref: EC:3.1.13.-
is_a: GO:0008408 ! 3'-5' exonuclease activity
is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0000176
name: nuclear exosome (RNase complex)
namespace: cellular_component
def: "Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791]
synonym: "eukaryotic exosome multienzyme ribonuclease complex" EXACT []
synonym: "nuclear exosome (ribonuclease complex)" EXACT []
synonym: "nuclear exosome multienzyme ribonuclease complex" EXACT []
is_a: GO:0000178 ! exosome (RNase complex)
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000177
name: cytoplasmic exosome (RNase complex)
namespace: cellular_component
def: "Complex of 3'-5' exoribonucleases found in the cytoplasm." [PMID:10465791]
synonym: "cytoplasmic exosome (ribonuclease complex)" EXACT []
synonym: "cytoplasmic exosome multienzyme ribonuclease complex" EXACT []
synonym: "prokaryotic exosome multienzyme ribonuclease complex" EXACT []
is_a: GO:0000178 ! exosome (RNase complex)
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000178
name: exosome (RNase complex)
namespace: cellular_component
def: "Complex of 3'-5' exoribonucleases." [PMID:10465791]
comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies.
subset: goslim_pir
synonym: "exosome (ribonucleasease complex)" EXACT []
synonym: "exosome multienzyme ribonuclease complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000179
name: rRNA (adenine-N6,N6-)-dimethyltransferase activity
namespace: molecular_function
alt_id: GO:0043790
def: "Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337 "Modification and Editing of RNA", PMID:10690410]
subset: gosubset_prok
synonym: "18S rRNA dimethylase activity" EXACT []
synonym: "dimethyladenosine transferase activity" EXACT [IMG:02532]
synonym: "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity" EXACT [IMG:02532]
xref: EC:2.1.1.-
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity

[Term]
id: GO:0000180
name: cytosolic large ribosomal subunit
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because more specific children exist.
is_obsolete: true
consider: GO:0022625

[Term]
id: GO:0000181
name: cytosolic small ribosomal subunit
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because more specific children exist.
is_obsolete: true
consider: GO:0022627

[Term]
id: GO:0000182
name: rDNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA." [GOC:mah]
synonym: "ribosomal DNA binding" EXACT []
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0000183
name: chromatin silencing at rDNA
namespace: biological_process
def: "Repression of transcription of ribosomal DNA by altering the structure of chromatin." [PMID:10219245]
synonym: "chromatin silencing at ribosomal DNA" EXACT []
synonym: "heterochromatic silencing at rDNA" EXACT []
is_a: GO:0006342 ! chromatin silencing

[Term]
id: GO:0000184
name: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
namespace: biological_process
def: "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395]
synonym: "mRNA breakdown, nonsense-mediated decay" EXACT []
synonym: "mRNA catabolic process, nonsense-mediated" EXACT []
synonym: "mRNA catabolism, nonsense-mediated" EXACT []
synonym: "mRNA degradation, nonsense-mediated decay" EXACT []
synonym: "nonsense-mediated mRNA decay" EXACT []
synonym: "nuclear mRNA catabolic process, nonsense-mediated decay" EXACT []
xref: Wikipedia:Nonsense-mediated_decay
xref: Wikipedia:Nonsense-mediated_mRNA_decay
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0000185
name: activation of MAPKKK activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase." [PMID:9561267]
synonym: "activation of MAP kinase kinase kinase" EXACT []
synonym: "activation of MAPKKK activity during sporulation" NARROW []
synonym: "positive regulation of MAP kinase kinase kinase activity" BROAD []
synonym: "positive regulation of MAPKKK activity" BROAD []
is_a: GO:0032147 ! activation of protein kinase activity
relationship: part_of GO:0000165 ! MAPKKK cascade

[Term]
id: GO:0000186
name: activation of MAPKK activity
namespace: biological_process
alt_id: GO:0007255
def: "The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK." [PMID:9561267]
synonym: "activation of MAP kinase kinase activity" EXACT []
synonym: "activation of MAP/ERK kinase kinase" EXACT []
synonym: "activation of MAPKK activity during sporulation" NARROW []
synonym: "positive regulation of MAPKK activity" BROAD []
xref: Reactome:110049 "MEK activation"
xref: Reactome:169893 "Prolonged ERK activation events"
xref: Reactome:448462 "Prolonged ERK activation events"
xref: Reactome:448644 "MEK activation"
xref: Reactome:469592 "Prolonged ERK activation events"
xref: Reactome:469772 "MEK activation"
xref: Reactome:487311 "Prolonged ERK activation events"
xref: Reactome:487466 "MEK activation"
xref: Reactome:507262 "Prolonged ERK activation events"
xref: Reactome:507426 "MEK activation"
xref: Reactome:517288 "Prolonged ERK activation events"
xref: Reactome:517429 "MEK activation"
xref: Reactome:526166 "Prolonged ERK activation events"
xref: Reactome:526303 "MEK activation"
xref: Reactome:531362 "Prolonged ERK activation events"
xref: Reactome:536738 "Prolonged ERK activation events"
xref: Reactome:542487 "Prolonged ERK activation events"
xref: Reactome:547814 "Prolonged ERK activation events"
xref: Reactome:552382 "Prolonged ERK activation events"
xref: Reactome:557987 "Prolonged ERK activation events"
xref: Reactome:568638 "Prolonged ERK activation events"
xref: Reactome:581842 "Prolonged ERK activation events"
xref: Reactome:592748 "Prolonged ERK activation events"
xref: Reactome:595483 "Prolonged ERK activation events"
is_a: GO:0006468 ! protein amino acid phosphorylation
is_a: GO:0032147 ! activation of protein kinase activity
relationship: part_of GO:0000165 ! MAPKKK cascade

[Term]
id: GO:0000187
name: activation of MAPK activity
namespace: biological_process
def: "The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK." [PMID:9561267]
synonym: "activation of MAP kinase" EXACT []
synonym: "activation of MAPK activity during sporulation" NARROW []
synonym: "MAPK activation" EXACT []
xref: Reactome:112409 "ERK activation"
xref: Reactome:449038 "ERK activation"
xref: Reactome:470153 "ERK activation"
xref: Reactome:487848 "ERK activation"
xref: Reactome:507814 "ERK activation"
xref: Reactome:517728 "ERK activation"
xref: Reactome:526564 "ERK activation"
xref: Reactome:531354 "ERK activation"
xref: Reactome:536730 "ERK activation"
xref: Reactome:542479 "ERK activation"
xref: Reactome:547806 "ERK activation"
xref: Reactome:552370 "ERK activation"
xref: Reactome:557979 "ERK activation"
xref: Reactome:568626 "ERK activation"
xref: Reactome:581830 "ERK activation"
xref: Reactome:592740 "ERK activation"
xref: Reactome:595471 "ERK activation"
is_a: GO:0006468 ! protein amino acid phosphorylation
is_a: GO:0043406 ! positive regulation of MAP kinase activity
relationship: part_of GO:0000165 ! MAPKKK cascade

[Term]
id: GO:0000188
name: inactivation of MAPK activity
namespace: biological_process
def: "Any process that terminates the activity of the active enzyme MAP kinase." [PMID:9561267]
synonym: "inactivation of MAPK during sporulation" NARROW []
synonym: "termination of MAPK activity" EXACT []
is_a: GO:0043407 ! negative regulation of MAP kinase activity
relationship: part_of GO:0000165 ! MAPKKK cascade

[Term]
id: GO:0000189
name: nuclear translocation of MAPK
namespace: biological_process
def: "The directed movement of a MAP kinase to the nucleus upon activation." [PMID:9561267]
xref: Reactome:109867 "Nuclear translocation of phospho-ERK-1 dimer"
xref: Reactome:109868 "Nuclear translocation of phospho-ERK-2 dimer"
xref: Reactome:112353 "Nuclear translocation of phospho-ERK-2 dimer"
xref: Reactome:443338 "Nuclear translocation of phospho-ERK-1 dimer"
xref: Reactome:443339 "Nuclear translocation of phospho-ERK-2 dimer"
xref: Reactome:483352 "Nuclear translocation of phospho-ERK-1 dimer"
xref: Reactome:483353 "Nuclear translocation of phospho-ERK-2 dimer"
xref: Reactome:503581 "Nuclear translocation of phospho-ERK-1 dimer"
xref: Reactome:503582 "Nuclear translocation of phospho-ERK-2 dimer"
xref: Reactome:515396 "Nuclear translocation of phospho-ERK-1 dimer"
xref: Reactome:515397 "Nuclear translocation of phospho-ERK-2 dimer"
xref: Reactome:524445 "Nuclear translocation of phospho-ERK-1 dimer"
xref: Reactome:524446 "Nuclear translocation of phospho-ERK-2 dimer"
xref: Reactome:530071 "Nuclear translocation of phospho-ERK-1 dimer"
xref: Reactome:530073 "Nuclear translocation of phospho-ERK-2 dimer"
xref: Reactome:535416 "Nuclear translocation of phospho-ERK-1 dimer"
xref: Reactome:535418 "Nuclear translocation of phospho-ERK-2 dimer"
xref: Reactome:541033 "Nuclear translocation of phospho-ERK-1 dimer"
xref: Reactome:541035 "Nuclear translocation of phospho-ERK-2 dimer"
xref: Reactome:546560 "Nuclear translocation of phospho-ERK-1 dimer"
xref: Reactome:546562 "Nuclear translocation of phospho-ERK-2 dimer"
xref: Reactome:551307 "Nuclear translocation of phospho-ERK-1 dimer"
xref: Reactome:551309 "Nuclear translocation of phospho-ERK-2 dimer"
xref: Reactome:556628 "Nuclear translocation of phospho-ERK-1 dimer"
xref: Reactome:556630 "Nuclear translocation of phospho-ERK-2 dimer"
xref: Reactome:566516 "Nuclear translocation of phospho-ERK-1 dimer"
xref: Reactome:566518 "Nuclear translocation of phospho-ERK-2 dimer"
xref: Reactome:579395 "Nuclear translocation of phospho-ERK-1 dimer"
xref: Reactome:579397 "Nuclear translocation of phospho-ERK-2 dimer"
xref: Reactome:591155 "Nuclear translocation of phospho-ERK-1 dimer"
xref: Reactome:591157 "Nuclear translocation of phospho-ERK-2 dimer"
xref: Reactome:594785 "Nuclear translocation of phospho-ERK-1 dimer"
xref: Reactome:594787 "Nuclear translocation of phospho-ERK-2 dimer"
is_a: GO:0000060 ! protein import into nucleus, translocation
relationship: part_of GO:0000165 ! MAPKKK cascade

[Term]
id: GO:0000190
name: MAPKKK cascade (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000191
name: activation of MAPKKK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000192
name: activation of MAPKK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000193
name: activation of MAPK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000194
name: inactivation of MAPK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000195
name: nuclear translocation of MAPK (pseudohyphal growth)
namespace: biological_process
def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000196
name: MAPKKK cascade involved in cell wall biogenesis
namespace: biological_process
def: "A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267]
synonym: "cell wall biogenesis, MAPKKK cascade" EXACT []
is_a: GO:0000165 ! MAPKKK cascade
relationship: part_of GO:0042546 ! cell wall biogenesis

[Term]
id: GO:0000197
name: activation of MAPKKK activity involved in cell wall biogenesis
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267]
synonym: "activation of MAP kinase kinase kinase activity during cell wall biogenesis" EXACT []
synonym: "cell wall biogenesis, activation of MAP kinase kinase kinase activity" EXACT []
synonym: "cell wall biogenesis, activation of MAPKKK activity" EXACT []
is_a: GO:0000185 ! activation of MAPKKK activity
relationship: part_of GO:0000196 ! MAPKKK cascade involved in cell wall biogenesis

[Term]
id: GO:0000198
name: activation of MAPKK activity involved in cell wall biogenesis
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267]
synonym: "activation of MAP kinase kinase activity during cell wall biogenesis" EXACT []
synonym: "cell wall biogenesis, activation of MAP kinase kinase activity" EXACT []
synonym: "cell wall biogenesis, activation of MAPKK activity" EXACT []
is_a: GO:0000186 ! activation of MAPKK activity
relationship: part_of GO:0000196 ! MAPKKK cascade involved in cell wall biogenesis

[Term]
id: GO:0000199
name: activation of MAPK activity involved in cell wall biogenesis
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267]
synonym: "cell wall biogenesis, activation of MAPK activity" EXACT []
is_a: GO:0000187 ! activation of MAPK activity
relationship: part_of GO:0000196 ! MAPKKK cascade involved in cell wall biogenesis

[Term]
id: GO:0000200
name: inactivation of MAPK activity involved in cell wall biogenesis
namespace: biological_process
def: "Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267]
synonym: "cell wall biogenesis, inactivation of MAPK activity" EXACT []
synonym: "cell wall biogenesis, termination of MAPK activity" EXACT []
synonym: "termination of MAPK activity during cell wall biogenesis" EXACT []
is_a: GO:0000188 ! inactivation of MAPK activity
relationship: part_of GO:0000196 ! MAPKKK cascade involved in cell wall biogenesis

[Term]
id: GO:0000201
name: nuclear translocation of MAPK involved in cell wall biogenesis
namespace: biological_process
def: "The directed movement of a MAP kinase to the nucleus that occurs in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267]
synonym: "cell wall biogenesis, nuclear translocation of MAPK" EXACT []
is_a: GO:0000189 ! nuclear translocation of MAPK
relationship: part_of GO:0000196 ! MAPKKK cascade involved in cell wall biogenesis

[Term]
id: GO:0000202
name: MAPKKK cascade during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000203
name: activation of MAPKKK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000204
name: activation of MAPKK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000205
name: activation of MAPK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000206
name: inactivation of MAPK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000207
name: nuclear translocation of MAPK during sporulation (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0000208
name: nuclear translocation of MAPK involved in osmosensory signaling pathway
namespace: biological_process
def: "The directed movement of a MAP kinase to the nucleus during osmolarity sensing." [PMID:9561267]
synonym: "nuclear translocation of MAPK during osmolarity sensing" EXACT []
synonym: "osmolarity sensing, nuclear translocation of MAPK" EXACT []
is_a: GO:0000189 ! nuclear translocation of MAPK
is_a: GO:0023034 ! intracellular signaling pathway
relationship: part_of GO:0000161 ! MAPKKK cascade involved in osmosensory signaling pathway

[Term]
id: GO:0000209
name: protein polyubiquitination
namespace: biological_process
def: "Addition of multiple ubiquitin moieties to a protein, forming a ubiquitin chain." [ISBN:0815316194]
synonym: "polyubiquitin" RELATED []
synonym: "protein polyubiquitinylation" EXACT []
synonym: "protein polyubiquitylation" EXACT []
is_a: GO:0016567 ! protein ubiquitination

[Term]
id: GO:0000210
name: NAD+ diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + H2O = AMP + NMN." [EC:3.6.1.22]
subset: gosubset_prok
synonym: "NAD diphosphatase activity" EXACT []
synonym: "NAD pyrophosphatase activity" EXACT []
synonym: "NAD(+) pyrophosphatase activity" EXACT [EC:3.6.1.22]
synonym: "NAD+ phosphohydrolase activity" EXACT [EC:3.6.1.22]
synonym: "NAD+ pyrophosphatase activity" EXACT [EC:3.6.1.22]
synonym: "NADH pyrophosphatase activity" EXACT [EC:3.6.1.22]
synonym: "NADP pyrophosphatase activity" BROAD [EC:3.6.1.22]
synonym: "nicotinamide adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.22]
xref: EC:3.6.1.22
xref: MetaCyc:NADPYROPHOSPHAT-RXN
is_a: GO:0004551 ! nucleotide diphosphatase activity

[Term]
id: GO:0000211
name: protein degradation tagging activity
namespace: molecular_function
def: "OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction." [GOC:cl, ISBN:0815316194]
comment: This term was made obsolete because it represents a biological process and a molecular function.
is_obsolete: true
consider: GO:0005515
consider: GO:0019941
consider: GO:0042787

[Term]
id: GO:0000212
name: meiotic spindle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah]
synonym: "meiotic spindle organisation" EXACT [GOC:curators]
synonym: "meiotic spindle organization and biogenesis" RELATED [GOC:mah]
synonym: "spindle organization during meiosis" EXACT [GOC:mah]
is_a: GO:0007051 ! spindle organization
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0000213
name: tRNA-intron endonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9]
synonym: "splicing endonuclease activity" EXACT [EC:3.1.27.9]
synonym: "transfer ribonucleate intron endoribonuclease activity" EXACT [EC:3.1.27.9]
synonym: "transfer splicing endonuclease activity" EXACT [EC:3.1.27.9]
synonym: "tRNA splicing endonuclease activity" EXACT [EC:3.1.27.9]
synonym: "tRNA-intron endoribonuclease activity" EXACT []
synonym: "tRNA-splicing endonuclease activity" EXACT [EC:3.1.27.9]
synonym: "tRNATRPintron endonuclease activity" EXACT [EC:3.1.27.9]
xref: EC:3.1.27.9
xref: MetaCyc:3.1.27.9-RXN
is_a: GO:0004549 ! tRNA-specific ribonuclease activity
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0000214
name: tRNA-intron endonuclease complex
namespace: cellular_component
def: "A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000215
name: tRNA 2'-phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O; transfers the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate." [EC:2.7.1.160, PMID:9148937]
synonym: "2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160]
synonym: "2'-phospho-tRNA:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160]
synonym: "Tpt1" RELATED [EC:2.7.1.160]
synonym: "Tpt1p" RELATED [EC:2.7.1.160]
synonym: "yeast 2'-phosphotransferase activity" NARROW [EC:2.7.1.160]
xref: EC:2.7.1.160
xref: MetaCyc:2.7.1.160-RXN
is_a: GO:0008665 ! 2'-phosphotransferase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0000216
name: M/G1 transition of mitotic cell cycle
namespace: biological_process
def: "Progression from M phase to G1 phase of the mitotic cell cycle." [GOC:mah]
xref: Reactome:448848 "M/G1 Transition"
xref: Reactome:469965 "M/G1 Transition"
xref: Reactome:487673 "M/G1 Transition"
xref: Reactome:507626 "M/G1 Transition"
xref: Reactome:517592 "M/G1 Transition"
xref: Reactome:526500 "M/G1 Transition"
xref: Reactome:531456 "M/G1 Transition"
xref: Reactome:536691 "M/G1 Transition"
xref: Reactome:542424 "M/G1 Transition"
xref: Reactome:547773 "M/G1 Transition"
xref: Reactome:552495 "M/G1 Transition"
xref: Reactome:568509 "M/G1 Transition"
xref: Reactome:581720 "M/G1 Transition"
xref: Reactome:592621 "M/G1 Transition"
xref: Reactome:597377 "M/G1 Transition"
xref: Reactome:68874 "M/G1 Transition"
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051329 ! interphase of mitotic cell cycle

[Term]
id: GO:0000217
name: DNA secondary structure binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions." [GOC:krc]
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0000219
name: vacuolar hydrogen-transporting ATPase
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "V-ATPase" EXACT []
is_obsolete: true
consider: GO:0016469

[Term]
id: GO:0000220
name: vacuolar proton-transporting V-type ATPase, V0 domain
namespace: cellular_component
def: "The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
comment: Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit.
synonym: "vacuolar hydrogen ion-transporting ATPase V0 domain" EXACT []
is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex

[Term]
id: GO:0000221
name: vacuolar proton-transporting V-type ATPase, V1 domain
namespace: cellular_component
def: "The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553]
comment: Note that this domain generally consists of eight subunits.
synonym: "vacuolar hydrogen ion-transporting ATPase V1 domain" EXACT []
is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex

[Term]
id: GO:0000222
name: plasma membrane proton-transporting V-type ATPase, V0 domain
namespace: cellular_component
def: "The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah]
synonym: "plasma membrane hydrogen ion-transporting ATPase V0 domain" EXACT []
is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane
relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex

[Term]
id: GO:0000223
name: plasma membrane proton-transporting V-type ATPase, V1 domain
namespace: cellular_component
def: "The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah]
synonym: "plasma membrane hydrogen ion-transporting ATPase V1 domain" EXACT []
is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane
relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex

[Term]
id: GO:0000224
name: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52]
subset: gosubset_prok
synonym: "glycopeptidase activity" BROAD [EC:3.5.1.52]
synonym: "glycopeptide N-glycosidase activity" BROAD [EC:3.5.1.52]
synonym: "jack-bean glycopeptidase" NARROW [EC:3.5.1.52]
synonym: "N-glycanase activity" RELATED [EC:3.5.1.52]
synonym: "N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.52]
synonym: "N-oligosaccharide glycopeptidase activity" RELATED [EC:3.5.1.52]
synonym: "peptide:N-glycanase" RELATED []
synonym: "PNGase" EXACT []
synonym: "PNGase A" RELATED [EC:3.5.1.52]
synonym: "PNGase F" RELATED [EC:3.5.1.52]
xref: EC:3.5.1.52
xref: MetaCyc:3.5.1.52-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0000225
name: N-acetylglucosaminylphosphatidylinositol deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. The second step enzyme catalyzing the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane. Catalyzes the N-deacetylation of GlcNAc-PI to GlcN-PI." [EC:3.5.1.89]
comment: Note that this function was formerly EC:3.1.1.69.
synonym: "6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity" EXACT [EC:3.5.1.89]
synonym: "acetylglucosaminylphosphatidylinositol deacetylase activity" EXACT [EC:3.5.1.89]
synonym: "GlcNAc-PI de-N-acetylase activity" EXACT [EC:3.5.1.89]
synonym: "GlcNAc-PI deacetylase activity" EXACT [EC:3.5.1.89]
synonym: "N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity" EXACT [EC:3.5.1.89]
synonym: "N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity" EXACT [EC:3.5.1.89]
xref: EC:3.5.1.89
xref: MetaCyc:3.1.1.69-RXN
xref: Reactome:22619 "N-acetylglucosaminylphosphatidylinositol deacetylase activity"
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0000226
name: microtubule cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah]
synonym: "microtubule dynamics" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0007017 ! microtubule-based process

[Term]
id: GO:0000227
name: oxaloacetate secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
synonym: "oxaloacetate carrier activity" RELATED []
is_a: GO:0015131 ! oxaloacetate transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0000228
name: nuclear chromosome
namespace: cellular_component
def: "A chromosome found in the nucleus of a eukaryotic cell." [GOC:mah]
subset: goslim_generic
synonym: "nuclear interphase chromosome" NARROW []
is_a: GO:0005694 ! chromosome
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000229
name: cytoplasmic chromosome
namespace: cellular_component
def: "A chromosome found in the cytoplasm." [GOC:mah]
subset: goslim_generic
subset: gosubset_prok
synonym: "cytoplasmic interphase chromosome" NARROW []
is_a: GO:0005694 ! chromosome
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000230
name: nuclear mitotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the nucleus during mitosis." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
is_obsolete: true
consider: GO:0000794

[Term]
id: GO:0000231
name: cytoplasmic mitotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cytoplasm during mitosis." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
is_obsolete: true
consider: GO:0000793

[Term]
id: GO:0000232
name: nuclear interphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the nucleus during interphase." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
is_obsolete: true
consider: GO:0000228

[Term]
id: GO:0000233
name: cytoplasmic interphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cytoplasm during interphase." [GOC:mah]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
is_obsolete: true
consider: GO:0000229

[Term]
id: GO:0000234
name: phosphoethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate." [EC:2.1.1.103]
synonym: "phosphoethanolamine methyltransferase activity" EXACT [EC:2.1.1.103]
synonym: "S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity" EXACT [EC:2.1.1.103]
xref: EC:2.1.1.103
xref: MetaCyc:2.1.1.103-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0000235
name: astral microtubule
namespace: cellular_component
def: "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194]
is_a: GO:0005876 ! spindle microtubule
is_a: GO:0005881 ! cytoplasmic microtubule
relationship: part_of GO:0005818 ! aster

[Term]
id: GO:0000236
name: mitotic prometaphase
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:dph, GOC:mah, ISBN:0198547684]
xref: Reactome:449172 "Mitotic Prometaphase"
xref: Reactome:470285 "Mitotic Prometaphase"
xref: Reactome:487961 "Mitotic Prometaphase"
xref: Reactome:507935 "Mitotic Prometaphase"
xref: Reactome:517873 "Mitotic Prometaphase"
xref: Reactome:526699 "Mitotic Prometaphase"
xref: Reactome:531472 "Mitotic Prometaphase"
xref: Reactome:536857 "Mitotic Prometaphase"
xref: Reactome:542610 "Mitotic Prometaphase"
xref: Reactome:547928 "Mitotic Prometaphase"
xref: Reactome:552504 "Mitotic Prometaphase"
xref: Reactome:558135 "Mitotic Prometaphase"
xref: Reactome:586012 "Mitotic Prometaphase"
xref: Reactome:592868 "Mitotic Prometaphase"
xref: Reactome:68877 "Mitotic Prometaphase"
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0007067 ! mitosis

[Term]
id: GO:0000237
name: leptotene
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through the first stage of prophase I in meiosis, in which chromosomes first become visible." [GOC:dph, GOC:mah, ISBN:0198547684]
xref: Wikipedia:Leptotene
xref: Wikipedia:Meiosis#Leptotene
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000238
name: zygotene
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through the second stage of prophase I in meiosis, in which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [GOC:dph, GOC:mah, ISBN:0198547684]
xref: Wikipedia:Meiosis#Zygotene
xref: Wikipedia:Zygotene
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000239
name: pachytene
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GOC:dph, GOC:mah, ISBN:0198547684]
xref: Wikipedia:Meiosis#Pachytene
xref: Wikipedia:Pachytene
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000240
name: diplotene
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GOC:dph, GOC:mah, ISBN:0198547684]
xref: Wikipedia:Diplotene
xref: Wikipedia:Meiosis#Diplotene
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000241
name: diakinesis
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [GOC:dph, GOC:mah, ISBN:0198547684]
xref: Wikipedia:Diakinesis
xref: Wikipedia:Meiosis#Diakinesis
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0000242
name: pericentriolar material
namespace: cellular_component
def: "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194]
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0000243
name: commitment complex
namespace: cellular_component
def: "A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript." [GOC:krc, ISBN:0879695897, PMID:9150140]
synonym: "mammalian spliceosomal complex E" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "mammalian spliceosomal E complex" NARROW [GOC:mah]
synonym: "yeast spliceosomal complex CC" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex

[Term]
id: GO:0000244
name: assembly of spliceosomal tri-snRNP
namespace: biological_process
alt_id: GO:0000351
alt_id: GO:0000355
def: "The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex." [ISBN:0879695897, PMID:9452384]
synonym: "assembly of spliceosomal tri-snRNP U4/U6.U5" NARROW []
synonym: "assembly of spliceosomal tri-snRNP U4atac/U6atac.U5" NARROW []
synonym: "snRNP recycling" BROAD []
synonym: "spliceosomal tri-snRNP assembly" EXACT []
synonym: "spliceosomal tri-snRNP U4/U6.U5 assembly" NARROW []
synonym: "spliceosomal tri-snRNP U4atac/U6atac.U5 assembly" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000387 ! spliceosomal snRNP assembly

[Term]
id: GO:0000245
name: spliceosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the spliceosome, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0000246
name: delta24(24-1) sterol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: ergosterol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3-beta-ol + NADPH + H+." [EC:1.3.1.71, PMID:10722850]
subset: gosubset_prok
synonym: "C-24(28) sterol reductase activity" EXACT [EC:1.3.1.71]
synonym: "D24(24-1)-sterol reductase activity" EXACT []
synonym: "delta24(241)-sterol reductase activity" EXACT [EC:1.3.1.71]
synonym: "ergosterol:NADP+ delta24(241)-oxidoreductase activity" EXACT [EC:1.3.1.71]
synonym: "sterol Delta(24(28))-methylene reductase activity" EXACT [EC:1.3.1.71]
synonym: "sterol Delta(24(28))-reductase activity" EXACT [EC:1.3.1.71]
synonym: "sterol delta-24(28) methylene reductase activity" EXACT []
synonym: "sterol delta-24(28) reductase activity" EXACT []
synonym: "sterol delta24(28)-methylene reductase activity" EXACT [EC:1.3.1.71]
synonym: "sterol delta24(28)-reductase activity" EXACT [EC:1.3.1.71]
xref: EC:1.3.1.71
xref: MetaCyc:1.3.1.71-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000247
name: C-8 sterol isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols." [MetaCyc:RXN3O-203, PMID:8988026]
synonym: "delta-8-delta-7 sterol isomerase activity" EXACT []
xref: EC:5.3.3.-
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0000248
name: C-5 sterol desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227]
synonym: "sterol-C5-desaturase activity" EXACT []
xref: Reactome:22657 "C-5 sterol desaturase activity"
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
is_a: GO:0070704 ! sterol desaturase activity

[Term]
id: GO:0000249
name: C-22 sterol desaturase activity
namespace: molecular_function
def: "Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction is 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227]
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
is_a: GO:0070704 ! sterol desaturase activity

[Term]
id: GO:0000250
name: lanosterol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus." [EC:5.4.99.7]
subset: gosubset_prok
synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)" EXACT [EC:5.4.99.7]
synonym: "2,3-epoxysqualene lanosterol cyclase activity" EXACT [EC:5.4.99.7]
synonym: "2,3-epoxysqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7]
synonym: "2,3-epoxysqualene-lanosterol cyclase activity" EXACT []
synonym: "2,3-oxidosqualene sterol cyclase activity" BROAD [EC:5.4.99.7]
synonym: "2,3-oxidosqualene-lanosterol cyclase activity" EXACT [EC:5.4.99.7]
synonym: "lanosterol 2,3-oxidosqualene cyclase activity" EXACT [EC:5.4.99.7]
synonym: "OSC" EXACT []
synonym: "oxidosqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7]
synonym: "oxidosqualene-lanosterol cyclase activity" EXACT []
synonym: "oxidosqualene:lanosterol cyclase activity" EXACT [PMID:18033581]
synonym: "squalene 2,3-epoxide:lanosterol cyclase activity" EXACT [EC:5.4.99.7]
synonym: "squalene epoxidase-cyclase activity" BROAD [EC:5.4.99.7]
synonym: "squalene-2,3-oxide-lanosterol cyclase activity" EXACT [EC:5.4.99.7]
xref: EC:5.4.99.7
xref: MetaCyc:LANOSTEROL-SYNTHASE-RXN
xref: Reactome:22668 "lanosterol synthase activity"
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0000252
name: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H." [EC:1.1.1.170, PMID:9811880]
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170]
synonym: "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)" EXACT []
synonym: "3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED []
synonym: "3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity" RELATED []
synonym: "C-3 sterol dehydrogenase (C-4 decarboxylase) activity" RELATED []
synonym: "C-3 sterol dehydrogenase activity" RELATED []
synonym: "sterol 4alpha-carboxylic decarboxylase activity" RELATED []
synonym: "sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity" RELATED []
synonym: "sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)" RELATED []
xref: EC:1.1.1.-
xref: Reactome:22670 "C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000253
name: 3-keto sterol reductase activity
namespace: molecular_function
alt_id: GO:0050576
def: "Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+." [EC:1.1.1.270, GOC:mah, MetaCyc:1.1.1.270-RXN, MetaCyc:RXN3O-4110, MetaCyc:RXN66-19, MetaCyc:RXN66-24, MetaCyc:RXN66-314, MetaCyc:RXN66-319, PMID:9811880]
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
synonym: "3-keto-steroid reductase activity" EXACT []
synonym: "3-KSR activity" EXACT [EC:1.1.1.270]
synonym: "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase" RELATED [EC:1.1.1.270]
xref: EC:1.1.1.270
xref: MetaCyc:1.1.1.270-RXN
xref: MetaCyc:RXN3O-4110
xref: MetaCyc:RXN66-19
xref: MetaCyc:RXN66-24
xref: MetaCyc:RXN66-314
xref: MetaCyc:RXN66-319
xref: Reactome:81247 "3-keto-steroid reductase activity"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000254
name: C-4 methylsterol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H+ + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O." [EC:1.14.13.72, PMID:9811880]
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72]
synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72]
synonym: "4-methylsterol oxidase activity" EXACT []
synonym: "methylsterol hydroxylase activity" RELATED []
synonym: "methylsterol monooxygenase activity" RELATED []
xref: EC:1.14.13.72
xref: MetaCyc:1.14.13.72-RXN
xref: Reactome:22672 "C-4 methylsterol oxidase activity"
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0000255
name: allantoin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "allantoin metabolism" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0000256
name: allantoin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "allantoin breakdown" EXACT []
synonym: "allantoin catabolism" EXACT []
synonym: "allantoin degradation" EXACT []
is_a: GO:0000255 ! allantoin metabolic process
is_a: GO:0043605 ! cellular amide catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0000257
name: nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides." [EC:3.5.5.1, GOC:kd]
subset: gosubset_prok
synonym: "acetonitrilase activity" EXACT [EC:3.5.5.1]
synonym: "benzonitrilase activity" EXACT [EC:3.5.5.1]
synonym: "nitrile aminohydrolase activity" EXACT [EC:3.5.5.1]
xref: EC:3.5.5.1
xref: MetaCyc:3.5.5.1-RXN
xref: UM-BBD_enzymeID:e0283
is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles

[Term]
id: GO:0000258
name: isoleucine/valine:sodium symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in)." [TC:2.A.26.1.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0005283
consider: GO:0005304
consider: GO:0015188

[Term]
id: GO:0000259
name: intracellular nucleoside transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell." [GOC:ai]
comment: This term was made obsolete because it contains component and function information.
is_obsolete: true
replaced_by: GO:0005337
replaced_by: GO:0005622

[Term]
id: GO:0000260
name: hydrogen-translocating V-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.1, TC:3.A.2.2.3]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0046961

[Term]
id: GO:0000261
name: sodium-translocating V-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.2]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0046962

[Term]
id: GO:0000262
name: mitochondrial chromosome
namespace: cellular_component
def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah]
synonym: "mitochondrial DNA" NARROW []
synonym: "mitochondrial genome" RELATED []
synonym: "mtDNA" NARROW []
xref: NIF_Subcellular:sao1186327184
is_a: GO:0000229 ! cytoplasmic chromosome
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0042645 ! mitochondrial nucleoid

[Term]
id: GO:0000263
name: heterotrimeric G-protein GTPase, alpha-subunit
namespace: molecular_function
def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity." [GOC:mah, ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
consider: GO:0003924
consider: GO:0005834

[Term]
id: GO:0000264
name: heterotrimeric G-protein GTPase, beta-subunit
namespace: molecular_function
def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit." [GOC:mah, ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
consider: GO:0003924
consider: GO:0005834

[Term]
id: GO:0000265
name: heterotrimeric G-protein GTPase, gamma-subunit
namespace: molecular_function
def: "OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit." [GOC:mah, ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
consider: GO:0003924
consider: GO:0005834

[Term]
id: GO:0000266
name: mitochondrial fission
namespace: biological_process
def: "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192]
synonym: "mitochondrial division" EXACT []
synonym: "mitochondrial proliferation" RELATED []
is_a: GO:0048285 ! organelle fission
is_a: GO:0070584 ! mitochondrion morphogenesis

[Term]
id: GO:0000267
name: cell fraction
namespace: cellular_component
def: "A generic term for parts of cells prepared by disruptive biochemical techniques." [GOC:ma]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044464 ! cell part

[Term]
id: GO:0000268
name: peroxisome targeting sequence binding
namespace: molecular_function
alt_id: GO:0005051
def: "Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome." [GOC:mah, ISBN:0879693568]
synonym: "peroxisome targeting signal receptor" NARROW []
synonym: "PTS binding" EXACT []
synonym: "PTS receptor" NARROW []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0000269
name: toxin export channel activity
namespace: molecular_function
def: "Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport]
is_a: GO:0015288 ! porin activity
is_a: GO:0019534 ! toxin transporter activity

[Term]
id: GO:0000270
name: peptidoglycan metabolic process
namespace: biological_process
alt_id: GO:0009284
def: "The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "murein metabolic process" EXACT []
synonym: "murein metabolism" EXACT []
synonym: "peptidoglycan metabolism" EXACT []
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0000271
name: polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycan biosynthesis" EXACT []
synonym: "glycan biosynthetic process" EXACT []
synonym: "polysaccharide anabolism" EXACT []
synonym: "polysaccharide biosynthesis" EXACT []
synonym: "polysaccharide formation" EXACT []
synonym: "polysaccharide synthesis" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0016051 ! carbohydrate biosynthetic process

[Term]
id: GO:0000272
name: polysaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages." [GOC:go_curators]
subset: gosubset_prok
synonym: "polysaccharide breakdown" EXACT []
synonym: "polysaccharide catabolism" EXACT []
synonym: "polysaccharide degradation" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0016052 ! carbohydrate catabolic process

[Term]
id: GO:0000273
name: lipoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipoic acid, 1,2-dithiolane-3-pentanoic acid, a coenzyme involved in oxidative decarboxylation of keto acids." [GOC:ai, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "lipoic acid metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0000274
name: mitochondrial proton-transporting ATP synthase, stator stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core." [GOC:mtg_sensu, PMID:10838056]
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk
relationship: part_of GO:0000276 ! mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)

[Term]
id: GO:0000275
name: mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
namespace: cellular_component
def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled." [GOC:mtg_sensu, PMID:10838056]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD []
synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" BROAD []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)
relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex

[Term]
id: GO:0000276
name: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
namespace: cellular_component
def: "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056]
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o)
relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex

[Term]
id: GO:0000277
name: [cytochrome c]-lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c." [EC:2.1.1.59]
synonym: "cytochrome c (lysine) methyltransferase activity" EXACT [EC:2.1.1.59]
synonym: "cytochrome c methyltransferase activity" EXACT [EC:2.1.1.59]
synonym: "cytochrome c-lysine N-methyltransferase activity" EXACT [EC:2.1.1.59]
synonym: "cytochrome c-specific protein methylase III activity" EXACT [EC:2.1.1.59]
synonym: "cytochrome c-specific protein-lysine methyltransferase activity" EXACT [EC:2.1.1.59]
synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.59]
synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.59]
xref: EC:2.1.1.59
xref: MetaCyc:2.1.1.59-RXN
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity

[Term]
id: GO:0000278
name: mitotic cell cycle
namespace: biological_process
def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278]
xref: Reactome:448677 "Cell Cycle, Mitotic"
xref: Reactome:469800 "Cell Cycle, Mitotic"
xref: Reactome:487499 "Cell Cycle, Mitotic"
xref: Reactome:507454 "Cell Cycle, Mitotic"
xref: Reactome:517452 "Cell Cycle, Mitotic"
xref: Reactome:526326 "Cell Cycle, Mitotic"
xref: Reactome:531165 "Cell Cycle, Mitotic"
xref: Reactome:536540 "Cell Cycle, Mitotic"
xref: Reactome:542261 "Cell Cycle, Mitotic"
xref: Reactome:547605 "Cell Cycle, Mitotic"
xref: Reactome:552213 "Cell Cycle, Mitotic"
xref: Reactome:557803 "Cell Cycle, Mitotic"
xref: Reactome:568416 "Cell Cycle, Mitotic"
xref: Reactome:581618 "Cell Cycle, Mitotic"
xref: Reactome:585798 "Cell Cycle, Mitotic"
xref: Reactome:592515 "Cell Cycle, Mitotic"
xref: Reactome:595354 "Cell Cycle, Mitotic"
xref: Reactome:597330 "Cell Cycle, Mitotic"
xref: Reactome:598134 "Cell Cycle, Mitotic"
xref: Reactome:599681 "Cell Cycle, Mitotic"
xref: Reactome:600670 "Cell Cycle, Mitotic"
xref: Reactome:602495 "Cell Cycle, Mitotic"
xref: Reactome:69278 "Cell Cycle, Mitotic"
is_a: GO:0007049 ! cell cycle

[Term]
id: GO:0000279
name: M phase
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division." [GOC:dph, GOC:mah, ISBN:0815316194]
synonym: "M-phase" EXACT []
xref: Wikipedia:M_phase
is_a: GO:0022403 ! cell cycle phase

[Term]
id: GO:0000280
name: nuclear division
namespace: biological_process
def: "A process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah]
subset: goslim_pir
synonym: "karyokinesis" RELATED []
is_a: GO:0048285 ! organelle fission

[Term]
id: GO:0000281
name: cytokinesis after mitosis
namespace: biological_process
def: "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:ai]
is_a: GO:0033205 ! cytokinesis during cell cycle

[Term]
id: GO:0000282
name: cellular bud site selection
namespace: biological_process
def: "The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah]
comment: Note that this term was split from 'bud site selection/establishment of cell polarity (sensu Saccharomyces) ; GO:0007115' (a sibling term, 'establishment of cell polarity (sensu Saccharomyces) ; GO:0000283', was created but has since been merged with 'establishment of cell polarity' ; GO:0030010).
synonym: "bud site selection/establishment of cell polarity" BROAD []
is_a: GO:0007105 ! cytokinesis, site selection
is_a: GO:0030010 ! establishment of cell polarity
relationship: part_of GO:0033205 ! cytokinesis during cell cycle

[Term]
id: GO:0000284
name: shmoo orientation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is an organism specific term. The entire branch of the ontology was reorganized to be more generally applicable.
is_obsolete: true
replaced_by: GO:0000753

[Term]
id: GO:0000285
name: 1-phosphatidylinositol-3-phosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [EC:2.7.1.150]
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.150]
synonym: "phosphatidylinositol 3-phosphate 5-kinase activity" EXACT [EC:2.7.1.150]
synonym: "phosphatidylinositol-3-phosphate 5-kinase activity" EXACT []
synonym: "type III PIP kinase activity" RELATED [EC:2.7.1.150]
xref: EC:2.7.1.150
xref: MetaCyc:2.7.1.150-RXN
is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity

[Term]
id: GO:0000286
name: alanine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+." [EC:1.4.1.1]
subset: gosubset_prok
synonym: "AlaDH" RELATED [EC:1.4.1.1]
synonym: "alanine oxidoreductase activity" EXACT [EC:1.4.1.1]
synonym: "alpha-alanine dehydrogenase activity" EXACT [EC:1.4.1.1]
synonym: "L-alanine dehydrogenase activity" EXACT [EC:1.4.1.1]
synonym: "L-alanine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.1]
synonym: "NAD-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1]
synonym: "NAD-linked alanine dehydrogenase activity" EXACT [EC:1.4.1.1]
synonym: "NADH-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1]
xref: EC:1.4.1.1
xref: MetaCyc:ALANINE-DEHYDROGENASE-RXN
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0000287
name: magnesium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai]
subset: gosubset_prok
synonym: "magnesium binding" EXACT []
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0000288
name: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
namespace: biological_process
def: "A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc]
synonym: "deadenylation-dependent mRNA decay" EXACT []
synonym: "mRNA breakdown, deadenylation-dependent decay" EXACT []
synonym: "mRNA catabolic process, deadenylation-dependent" EXACT []
synonym: "mRNA catabolic process, deadenylylation-dependent" EXACT []
synonym: "mRNA catabolism, deadenylation-dependent" EXACT []
synonym: "mRNA catabolism, deadenylylation-dependent" EXACT []
synonym: "mRNA degradation, deadenylation-dependent decay" EXACT []
synonym: "nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0000289
name: nuclear-transcribed mRNA poly(A) tail shortening
namespace: biological_process
def: "Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc]
synonym: "3' to 5' mRNA deadenylation" RELATED []
synonym: "mRNA deadenylation" RELATED []
synonym: "nuclear mRNA poly(A) tail shortening" RELATED []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process
is_a: GO:0031124 ! mRNA 3'-end processing
relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

[Term]
id: GO:0000290
name: deadenylation-dependent decapping of nuclear-transcribed mRNA
namespace: biological_process
def: "Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc]
synonym: "deadenylation-dependent decapping of nuclear mRNA" EXACT []
synonym: "deadenylylation-dependent decapping" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process
relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

[Term]
id: GO:0000291
name: nuclear-transcribed mRNA catabolic process, exonucleolytic
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc]
synonym: "exonucleolytic degradation of mRNA" EXACT []
synonym: "mRNA breakdown, exonucleolytic" EXACT []
synonym: "mRNA degradation, exonucleolytic" EXACT []
synonym: "nuclear mRNA catabolic process, exonucleolytic" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0000292
name: RNA fragment catabolic process
namespace: biological_process
alt_id: GO:0030452
def: "The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing." [GOC:mah]
subset: gosubset_prok
synonym: "group I intron catabolic process" NARROW []
synonym: "RNA fragment breakdown" EXACT []
synonym: "RNA fragment catabolism" EXACT [GOC:mah]
synonym: "RNA fragment degradation" EXACT []
is_a: GO:0006401 ! RNA catabolic process

[Term]
id: GO:0000293
name: ferric-chelate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H+." [EC:1.16.1.7]
comment: Note that this function was formerly EC:1.6.99.13.
synonym: "Fe(II):NAD+ oxidoreductase activity" EXACT [EC:1.16.1.7]
synonym: "ferric chelate reductase activity" EXACT [EC:1.16.1.7]
synonym: "iron chelate reductase activity" RELATED [EC:1.16.1.7]
synonym: "NADH2:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7]
synonym: "NADH:Fe(3+) oxidoreductase activity" EXACT [EC:1.16.1.7]
synonym: "NADH:Fe(3+)-EDTA reductase activity" EXACT [EC:1.16.1.7]
synonym: "NADH:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7]
synonym: "NADH:Fe3+-EDTA reductase activity" EXACT [EC:1.16.1.7]
xref: EC:1.16.1.7
xref: MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0000294
name: nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay
namespace: biological_process
def: "A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends." [GOC:krc]
synonym: "endonucleolytic mRNA decay" EXACT []
synonym: "mRNA breakdown, endonucleolytic cleavage-dependent decay" EXACT []
synonym: "mRNA catabolic process, endonucleolytic" EXACT []
synonym: "mRNA catabolism, endonucleolytic" EXACT []
synonym: "mRNA degradation, endonucleolytic cleavage-dependent decay" EXACT []
synonym: "nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0000295
name: adenine nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of the membrane to the other." [PMID:11566870]
xref: Reactome:22791 "adenine nucleotide transmembrane transporter activity"
is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity

[Term]
id: GO:0000296
name: spermine transport
namespace: biological_process
def: "The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0015846 ! polyamine transport

[Term]
id: GO:0000297
name: spermine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of spermine from one side of the membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:ai]
is_a: GO:0015203 ! polyamine transmembrane transporter activity

[Term]
id: GO:0000298
name: endopolyphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues." [EC:3.6.1.10]
synonym: "metaphosphatase activity" BROAD [EC:3.6.1.10]
synonym: "polymetaphosphatase activity" EXACT [EC:3.6.1.10]
synonym: "polyphosphatase activity" BROAD [EC:3.6.1.10]
synonym: "polyphosphate depolymerase activity" BROAD [EC:3.6.1.10]
synonym: "polyphosphate polyphosphohydrolase activity" EXACT [EC:3.6.1.10]
xref: EC:3.6.1.10
xref: MetaCyc:ENDOPOLYPHOSPHATASE-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0000299
name: integral to membrane of membrane fraction
namespace: cellular_component
def: "Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes." [PMID:10512869]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
is_a: GO:0005624 ! membrane fraction

[Term]
id: GO:0000300
name: peripheral to membrane of membrane fraction
namespace: cellular_component
def: "Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH." [PMID:10512869]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
is_a: GO:0005624 ! membrane fraction

[Term]
id: GO:0000301
name: retrograde transport, vesicle recycling within Golgi
namespace: biological_process
def: "The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363]
synonym: "retrograde (vesicle recycling within Golgi) transport" EXACT []
is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport

[Term]
id: GO:0000302
name: response to reactive oxygen species
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc]
subset: gosubset_prok
synonym: "response to active oxygen species" EXACT []
synonym: "response to AOS" EXACT []
synonym: "response to reactive oxidative species" EXACT []
synonym: "response to reactive oxygen intermediate" EXACT []
synonym: "response to ROI" EXACT []
synonym: "response to ROS" EXACT []
is_a: GO:0006979 ! response to oxidative stress
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0000303
name: response to superoxide
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0000305 ! response to oxygen radical

[Term]
id: GO:0000304
name: response to singlet oxygen
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:krc, ISBN:0124325653, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0000302 ! response to reactive oxygen species

[Term]
id: GO:0000305
name: response to oxygen radical
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:krc, ISBN:0124325653]
subset: gosubset_prok
is_a: GO:0000302 ! response to reactive oxygen species

[Term]
id: GO:0000306
name: extrinsic to vacuolar membrane
namespace: cellular_component
def: "Loosely bound to one or the other surface of the vacuolar membrane, but not integrated into the hydrophobic region." [GOC:jl, GOC:mah, http://cancerweb.ncl.ac.uk/]
is_a: GO:0031312 ! extrinsic to organelle membrane
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0000307
name: cyclin-dependent protein kinase holoenzyme complex
namespace: cellular_component
def: "Cyclin-dependent protein kinases (CDKs) are heterodimeric enzymes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261]
subset: goslim_pir
synonym: "CDK holoenzyme" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000308
name: cytoplasmic cyclin-dependent protein kinase holoenzyme complex
namespace: cellular_component
def: "Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm." [GOC:krc]
synonym: "CDK holoenzyme" BROAD []
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000309
name: nicotinamide-nucleotide adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+." [EC:2.7.7.1]
subset: gosubset_prok
synonym: "adenosine triphosphate-nicotinamide mononucleotide transadenylase activity" EXACT [EC:2.7.7.1]
synonym: "ATP:nicotinamide-nucleotide adenylyltransferase activity" EXACT []
synonym: "ATP:NMN adenylyltransferase activity" EXACT [EC:2.7.7.1]
synonym: "diphosphopyridine nucleotide pyrophosphorylase activity" RELATED [EC:2.7.7.1]
synonym: "NAD(+) diphosphorylase activity" NARROW [EC:2.7.7.1]
synonym: "NAD(+) pyrophosphorylase activity" NARROW [EC:2.7.7.1]
synonym: "NAD+ diphosphorylase activity" EXACT [EC:2.7.7.1]
synonym: "NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.1]
synonym: "nicotinamide adenine dinucleotide pyrophosphorylase activity" NARROW [EC:2.7.7.1]
synonym: "nicotinamide mononucleotide adenylyltransferase activity" NARROW [EC:2.7.7.1]
synonym: "NMN adenylyltransferase activity" NARROW [EC:2.7.7.1]
synonym: "NMNAT activity" NARROW [EC:2.7.7.1]
xref: EC:2.7.7.1
xref: MetaCyc:2.7.7.1-RXN
xref: Reactome:23250 "nicotinamide-nucleotide adenylyltransferase activity"
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0000310
name: xanthine phosphoribosyltransferase activity
namespace: molecular_function
alt_id: GO:0009043
def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate; substrate specificity for xanthine." [EC:2.4.2.22, GOC:clt]
subset: gosubset_prok
synonym: "5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.22]
synonym: "Xan phosphoribosyltransferase activity" EXACT [EC:2.4.2.22]
synonym: "xanthine-guanine phosphoribosyltransferase activity" EXACT []
synonym: "xanthosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.22]
synonym: "xanthylate pyrophosphorylase activity" EXACT [EC:2.4.2.22]
synonym: "xanthylic pyrophosphorylase activity" EXACT [EC:2.4.2.22]
synonym: "XMP pyrophosphorylase activity" EXACT [EC:2.4.2.22]
synonym: "XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.22]
xref: EC:2.4.2.22
xref: MetaCyc:XANPRIBOSYLTRAN-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0000311
name: plastid large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
is_a: GO:0000315 ! organellar large ribosomal subunit
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009547 ! plastid ribosome

[Term]
id: GO:0000312
name: plastid small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of a plastid ribosome." [GOC:mcc]
is_a: GO:0000314 ! organellar small ribosomal subunit
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009547 ! plastid ribosome

[Term]
id: GO:0000313
name: organellar ribosome
namespace: cellular_component
def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc]
is_a: GO:0005840 ! ribosome

[Term]
id: GO:0000314
name: organellar small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of an organellar ribosome." [GOC:mcc]
is_a: GO:0015935 ! small ribosomal subunit
relationship: part_of GO:0000313 ! organellar ribosome

[Term]
id: GO:0000315
name: organellar large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
is_a: GO:0015934 ! large ribosomal subunit
relationship: part_of GO:0000313 ! organellar ribosome

[Term]
id: GO:0000316
name: sulfite transport
namespace: biological_process
def: "The directed movement of sulfite into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
synonym: "sulphite transport" EXACT []
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0000317
name: methionine-S-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine S-oxide + thioredoxin = L-methionine + thioredoxin disulfide. Thioredoxin disulfide is the oxidized form of thioredoxin. No reaction on oxidized methionine in peptide linkage." [PMID:11169920]
subset: gosubset_prok
synonym: "methionine sulfoxide reductase activity" EXACT []
is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0000318
name: protein-methionine-R-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.-, PMID:11929995]
subset: gosubset_prok
xref: EC:1.8.4.-
is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0000319
name: sulfite transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of sulfite ions from one side of a membrane to the other." [GOC:as]
synonym: "sulphite transporter activity" EXACT []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0000320
name: re-entry into mitotic cell cycle
namespace: biological_process
def: "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state." [GOC:krc]
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0000321
name: re-entry into mitotic cell cycle after pheromone arrest
namespace: biological_process
def: "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae." [GOC:krc, PMID:9927449]
is_a: GO:0000320 ! re-entry into mitotic cell cycle
is_a: GO:0000754 ! adaptation to pheromone during conjugation with cellular fusion
is_a: GO:0048610 ! reproductive cellular process

[Term]
id: GO:0000322
name: storage vacuole
namespace: cellular_component
def: "A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules." [GOC:krc]
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000323
name: lytic vacuole
namespace: cellular_component
def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc]
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000324
name: fungal-type vacuole
namespace: cellular_component
def: "A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure." [GOC:mah, GOC:mtg_sensu, ISBN:0879693649]
synonym: "vacuole, cell cycle-correlated morphology" EXACT []
is_a: GO:0000322 ! storage vacuole
is_a: GO:0000323 ! lytic vacuole

[Term]
id: GO:0000325
name: plant-type vacuole
namespace: cellular_component
def: "A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0815316208]
synonym: "vacuole, cell cycle-independent morphology" EXACT []
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0000326
name: protein storage vacuole
namespace: cellular_component
def: "A storage vacuole that contains a lytic vacuole; identified in plants." [PMID:11739409]
is_a: GO:0000322 ! storage vacuole
is_a: GO:0000325 ! plant-type vacuole

[Term]
id: GO:0000327
name: lytic vacuole within protein storage vacuole
namespace: cellular_component
def: "A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole." [PMID:11739490]
is_a: GO:0000323 ! lytic vacuole
relationship: part_of GO:0000326 ! protein storage vacuole

[Term]
id: GO:0000328
name: fungal-type vacuole lumen
namespace: cellular_component
def: "The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu]
synonym: "lumen of vacuole with cell cycle-correlated morphology" EXACT []
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0000324 ! fungal-type vacuole

[Term]
id: GO:0000329
name: fungal-type vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu]
synonym: "fungal-type vacuolar membrane" RELATED []
synonym: "membrane of vacuole with cell cycle-correlated morphology" EXACT []
is_a: GO:0005774 ! vacuolar membrane
relationship: part_of GO:0000324 ! fungal-type vacuole

[Term]
id: GO:0000330
name: plant-type vacuole lumen
namespace: cellular_component
def: "The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana." [GOC:krc, GOC:mtg_sensu]
synonym: "lumen of vacuole with cell cycle-independent morphology" EXACT []
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0000325 ! plant-type vacuole

[Term]
id: GO:0000331
name: contractile vacuole
namespace: cellular_component
def: "A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory." [GOC:jl, http://cancerweb.ncl.ac.uk/, PMID:10503189]
xref: Wikipedia:Contractile_vacuole
is_a: GO:0005773 ! vacuole
is_a: GO:0031988 ! membrane-bounded vesicle

[Term]
id: GO:0000332
name: template for synthesis of G-rich strand of telomere DNA activity
namespace: molecular_function
def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242]
comment: Note that this term describes the activity of an RNA gene product that interacts with other nucleic acid molecules via base pairing; it should not be used to annotate proteins.
synonym: "telomerase RNA" EXACT []
synonym: "telomerase, template" EXACT []
is_a: GO:0000497 ! base pairing with DNA
relationship: part_of GO:0003720 ! telomerase activity

[Term]
id: GO:0000333
name: telomerase catalytic core complex
namespace: cellular_component
def: "The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition." [PMID:11884619]
is_a: GO:0005697 ! telomerase holoenzyme complex

[Term]
id: GO:0000334
name: 3-hydroxyanthranilate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde." [EC:1.13.11.6]
subset: gosubset_prok
synonym: "3-hydroxyanthranilate oxygenase activity" EXACT [EC:1.13.11.6]
synonym: "3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.6]
synonym: "3-hydroxyanthranilic acid dioxygenase activity" EXACT [EC:1.13.11.6]
synonym: "3-hydroxyanthranilic acid oxygenase activity" EXACT [EC:1.13.11.6]
synonym: "3-hydroxyanthranilic oxygenase activity" EXACT [EC:1.13.11.6]
synonym: "3HAO" RELATED [EC:1.13.11.6]
xref: EC:1.13.11.6
xref: MetaCyc:1.13.11.6-RXN
xref: Reactome:23302 "3-hydroxyanthranilate 3,4-dioxygenase activity"
xref: UM-BBD_enzymeID:e0633
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0000335
name: negative regulation of transposition, DNA-mediated
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of DNA transposition" EXACT []
synonym: "down-regulation of DNA transposition" EXACT []
synonym: "downregulation of DNA transposition" EXACT []
synonym: "inhibition of DNA transposition" NARROW []
synonym: "negative regulation of DNA transposition" EXACT [GOC:dph]
is_a: GO:0000337 ! regulation of transposition, DNA-mediated
is_a: GO:0010529 ! negative regulation of transposition
is_a: GO:0045910 ! negative regulation of DNA recombination
relationship: negatively_regulates GO:0006313 ! transposition, DNA-mediated

[Term]
id: GO:0000336
name: positive regulation of transposition, DNA-mediated
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc]
subset: gosubset_prok
synonym: "activation of DNA transposition" NARROW []
synonym: "positive regulation of DNA transposition" EXACT [GOC:dph]
synonym: "stimulation of DNA transposition" NARROW []
synonym: "up regulation of DNA transposition" EXACT []
synonym: "up-regulation of DNA transposition" EXACT []
synonym: "upregulation of DNA transposition" EXACT []
is_a: GO:0000337 ! regulation of transposition, DNA-mediated
is_a: GO:0010530 ! positive regulation of transposition
is_a: GO:0045911 ! positive regulation of DNA recombination
relationship: positively_regulates GO:0006313 ! transposition, DNA-mediated

[Term]
id: GO:0000337
name: regulation of transposition, DNA-mediated
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule." [GOC:dph, GOC:krc]
subset: gosubset_prok
synonym: "regulation of DNA transposition" EXACT [GOC:dph]
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0010528 ! regulation of transposition
relationship: regulates GO:0006313 ! transposition, DNA-mediated

[Term]
id: GO:0000338
name: protein deneddylation
namespace: biological_process
def: "The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc]
is_a: GO:0043687 ! post-translational protein modification
is_a: GO:0070646 ! protein modification by small protein removal

[Term]
id: GO:0000339
name: RNA cap binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 7-methylguanosine (m7G) moiety or derivative located at the 5' end of an RNA molecule." [GOC:krc]
synonym: "binding to mRNA cap" NARROW []
synonym: "mRNA cap binding" NARROW []
synonym: "snRNA cap binding" NARROW []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0000340
name: RNA 7-methylguanosine cap binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the 7-methylguanosine moiety added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc]
synonym: "RNA m7G cap binding" EXACT []
is_a: GO:0000339 ! RNA cap binding

[Term]
id: GO:0000341
name: RNA trimethylguanosine cap binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the trimethylguanosine (m(3)(2,2,7)-GTP) moiety located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans." [GOC:krc]
synonym: "RNA m2,2,7G cap binding" EXACT []
is_a: GO:0000339 ! RNA cap binding

[Term]
id: GO:0000342
name: RNA cap 4 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa." [GOC:krc, PMID:10880518, PMID:12121975]
is_a: GO:0000339 ! RNA cap binding

[Term]
id: GO:0000343
name: plastid-encoded plastid RNA polymerase complex A
namespace: cellular_component
def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex." [PMID:10946105]
synonym: "PEP-A" EXACT []
is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex

[Term]
id: GO:0000344
name: plastid-encoded plastid RNA polymerase complex B
namespace: cellular_component
def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation." [PMID:10946105]
synonym: "PEP-B" EXACT []
is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex

[Term]
id: GO:0000345
name: cytosolic DNA-directed RNA polymerase complex
namespace: cellular_component
def: "The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity." [PMID:11158566]
subset: gosubset_prok
is_a: GO:0000428 ! DNA-directed RNA polymerase complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0000346
name: transcription export complex
namespace: cellular_component
def: "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans." [GOC:krc, PMID:11979277]
subset: goslim_pir
synonym: "TREX complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000347
name: THO complex
namespace: cellular_component
def: "The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000348
name: nuclear mRNA branch site recognition
namespace: biological_process
alt_id: GO:0000370
alt_id: GO:0000371
def: "Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents the formation of the B complex (yeast) or the A complex (mammalian).
synonym: "spliceosomal A complex biosynthesis" NARROW []
synonym: "spliceosomal A complex formation" NARROW []
synonym: "spliceosomal B complex biosynthesis" NARROW []
synonym: "spliceosomal B complex formation" NARROW []
synonym: "U12-type nuclear mRNA branch site recognition" NARROW []
synonym: "U2-type nuclear mRNA branch site recognition" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000245 ! spliceosome assembly

[Term]
id: GO:0000349
name: generation of catalytic spliceosome for first transesterification step
namespace: biological_process
alt_id: GO:0000356
alt_id: GO:0000357
def: "Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents the formation of the A2-2 complex (yeast) or the C1 complex (mammalian).
synonym: "catalytic spliceosome assembly for first transesterification step" RELATED []
synonym: "formation of catalytic spliceosome for first transesterification step" EXACT []
synonym: "spliceosomal A2-2 complex biosynthesis" NARROW []
synonym: "spliceosomal A2-2 complex formation" NARROW []
synonym: "spliceosomal C1 complex biosynthesis" NARROW []
synonym: "spliceosomal C1 complex formation" NARROW []
synonym: "U12-type catalytic spliceosome formation for first transesterification step" NARROW []
synonym: "U2-type catalytic spliceosome formation for first transesterification step" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation

[Term]
id: GO:0000350
name: generation of catalytic spliceosome for second transesterification step
namespace: biological_process
alt_id: GO:0000358
alt_id: GO:0000359
def: "Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents formation of the A2-3 complex (yeast) or the C2 complex (mammalian).
synonym: "catalytic spliceosome assembly for second transesterification step" RELATED []
synonym: "formation of catalytic spliceosome for second transesterification step" EXACT []
synonym: "formation of catalytic U12-type spliceosome for second transesterification step" NARROW []
synonym: "formation of catalytic U2-type spliceosome for second transesterification step" NARROW []
synonym: "formation of spliceosomal A2-2 complex" NARROW []
synonym: "formation of spliceosomal C1 complex" NARROW []
synonym: "lariat formation, 5'-splice site cleavage" RELATED []
synonym: "spliceosomal A2-3 complex biosynthesis" NARROW []
synonym: "spliceosomal A2-3 complex formation" NARROW []
synonym: "spliceosomal C2 complex biosynthesis" NARROW []
synonym: "spliceosomal C2 complex formation" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation

[Term]
id: GO:0000352
name: trans assembly of SL-containing precatalytic spliceosome
namespace: biological_process
def: "Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897]
synonym: "trans assembly of spliced leader-containing precatalytic spliceosome" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000245 ! spliceosome assembly
relationship: part_of GO:0045291 ! nuclear mRNA trans splicing, SL addition

[Term]
id: GO:0000353
name: formation of quadruple SL/U4/U5/U6 snRNP
namespace: biological_process
def: "Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA." [GOC:krc, ISBN:0879695897]
comment: Note that this step is analogous to 5' splice site selection in cis-splicing.
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0045291 ! nuclear mRNA trans splicing, SL addition

[Term]
id: GO:0000354
name: cis assembly of pre-catalytic spliceosome
namespace: biological_process
alt_id: GO:0000360
alt_id: GO:0000361
def: "Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897]
comment: Note that this step represents formation of the A2-1 complex (yeast) or the B1 complex (mammals).
synonym: "cis assembly of U12-type pre-catalytic spliceosome" NARROW []
synonym: "cis assembly of U2-type pre-catalytic spliceosome" NARROW []
synonym: "formation of spliceosomal A2-1 complex" NARROW []
synonym: "formation of spliceosomal B1 complex" NARROW []
synonym: "spliceosomal A2-1 complex biosynthesis" NARROW []
synonym: "spliceosomal A2-1 complex formation" NARROW []
synonym: "spliceosomal B1 complex biosynthesis" NARROW []
synonym: "spliceosomal B1 complex formation" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000245 ! spliceosome assembly
relationship: part_of GO:0045292 ! nuclear mRNA cis splicing, via spliceosome

[Term]
id: GO:0000362
name: first U2-type spliceosomal transesterification activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897]
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
synonym: "lariat formation, 5'-splice site cleavage" BROAD []
is_obsolete: true
replaced_by: GO:0000384

[Term]
id: GO:0000363
name: first U12-type spliceosomal transesterification activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897]
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
synonym: "lariat formation, 5'-splice site cleavage" BROAD []
is_obsolete: true
replaced_by: GO:0000384

[Term]
id: GO:0000364
name: second U2-type spliceosomal transesterification activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897]
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
synonym: "3'-splice site cleavage, exon ligation" BROAD []
is_obsolete: true
replaced_by: GO:0000386

[Term]
id: GO:0000365
name: nuclear mRNA trans splicing, via spliceosome
namespace: biological_process
def: "The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0879695897]
synonym: "nuclear mRNA trans splicing, via U2-type spliceosome" NARROW []
is_a: GO:0000398 ! nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0000366
name: intergenic nuclear mRNA trans splicing
namespace: biological_process
def: "The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing." [GOC:krc, PMID:11726664, PMID:12110900]
is_a: GO:0000365 ! nuclear mRNA trans splicing, via spliceosome
is_a: GO:0000380 ! alternative nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0000367
name: second U12-type spliceosomal transesterification activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897]
comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not.
synonym: "3'-splice site cleavage, exon ligation" BROAD []
is_obsolete: true
replaced_by: GO:0000386

[Term]
id: GO:0000372
name: Group I intron splicing
namespace: biological_process
def: "The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize)." [GOC:krc, PMID:11377794]
comment: Note that Group I introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; tRNA and mRNA of bacteria and bacteriophage; rRNA of protists and fungi; and occasionally in mRNA of animal mitochondria (e.g. sea anemone).
subset: gosubset_prok
synonym: "mRNA splicing" NARROW []
is_a: GO:0000376 ! RNA splicing, via transesterification reactions with guanosine as nucleophile

[Term]
id: GO:0000373
name: Group II intron splicing
namespace: biological_process
def: "The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat." [GOC:krc, PMID:11377794]
comment: Note that Group II introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; and mRNA of bacteria.
subset: gosubset_prok
synonym: "mRNA splicing" NARROW []
is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

[Term]
id: GO:0000374
name: Group III intron splicing
namespace: biological_process
def: "The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved." [GOC:krc, PMID:11377794]
comment: Note that Group III introns are known to be found in mRNA of plastids of euglenoid protists.
subset: gosubset_prok
synonym: "mRNA splicing" NARROW []
is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile

[Term]
id: GO:0000375
name: RNA splicing, via transesterification reactions
namespace: biological_process
alt_id: GO:0000385
alt_id: GO:0031202
def: "Splicing of RNA via a series of two transesterification reactions." [GOC:krc]
comment: Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism.
subset: gosubset_prok
synonym: "pre-mRNA splicing factor activity" RELATED [GOC:krc, GOC:mah]
synonym: "RNA splicing factor activity, transesterification mechanism" RELATED [GOC:krc, GOC:mah]
synonym: "spliceosomal catalysis" RELATED []
xref: Reactome:160901 "RNA splicing factor activity, transesterification mechanism"
is_a: GO:0008380 ! RNA splicing

[Term]
id: GO:0000376
name: RNA splicing, via transesterification reactions with guanosine as nucleophile
namespace: biological_process
def: "Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile." [GOC:krc, PMID:11377794]
subset: gosubset_prok
is_a: GO:0000375 ! RNA splicing, via transesterification reactions

[Term]
id: GO:0000377
name: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
namespace: biological_process
def: "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794]
subset: gosubset_prok
synonym: "lariat RNA biosynthesis" RELATED []
synonym: "lariat RNA formation" RELATED []
is_a: GO:0000375 ! RNA splicing, via transesterification reactions

[Term]
id: GO:0000378
name: RNA exon ligation
namespace: biological_process
def: "The process of joining two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction." [GOC:krc, ISBN:0879695897]
comment: Note that this is not a part of spliceosomal RNA splicing.
subset: gosubset_prok
is_a: GO:0016070 ! RNA metabolic process
relationship: part_of GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation

[Term]
id: GO:0000379
name: tRNA-type intron splice site recognition and cleavage
namespace: biological_process
def: "The process by which the tertiary structure of a tRNA type intron is recognized, and the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, ISBN:0879695897]
subset: gosubset_prok
is_a: GO:0006396 ! RNA processing
relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation

[Term]
id: GO:0000380
name: alternative nuclear mRNA splicing, via spliceosome
namespace: biological_process
def: "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900]
comment: Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals.
synonym: "splice site selection" BROAD []
is_a: GO:0000398 ! nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0000381
name: regulation of alternative nuclear mRNA splicing, via spliceosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc]
synonym: "splice site selection" BROAD []
is_a: GO:0048024 ! regulation of nuclear mRNA splicing, via spliceosome
relationship: regulates GO:0000380 ! alternative nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0000384
name: first spliceosomal transesterification activity
namespace: molecular_function
def: "Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon." [GOC:krc, ISBN:0879695897]
synonym: "lariat formation, 5'-splice site cleavage" NARROW []
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0000386
name: second spliceosomal transesterification activity
namespace: molecular_function
def: "Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure." [GOC:krc, ISBN:0879695897]
synonym: "3'-splice site cleavage, exon ligation" BROAD []
synonym: "lariat formation, 5'-splice site cleavage" NARROW []
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0000387
name: spliceosomal snRNP assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897]
synonym: "spliceosomal snRNP biogenesis" RELATED [GOC:mah]
xref: Reactome:191763 "snRNP:Snurportin complex formation"
xref: Reactome:191784 "snRNA Cap hypermethylation"
xref: Reactome:191786 "snRNP complex assembly"
xref: Reactome:191790 "Loading and methylation of Sm proteins onto SMN Complexes"
xref: Reactome:191859 "snRNP Assembly"
xref: Reactome:446947 "snRNA Cap hypermethylation"
xref: Reactome:446948 "snRNP complex assembly"
xref: Reactome:446968 "snRNP:Snurportin complex formation"
xref: Reactome:449216 "snRNP Assembly"
xref: Reactome:463701 "Loading and methylation of Sm proteins onto SMN Complexes"
xref: Reactome:468224 "snRNA Cap hypermethylation"
xref: Reactome:468225 "snRNP complex assembly"
xref: Reactome:468242 "snRNP:Snurportin complex formation"
xref: Reactome:470295 "snRNP Assembly"
xref: Reactome:486050 "snRNA Cap hypermethylation"
xref: Reactome:486051 "snRNP complex assembly"
xref: Reactome:486063 "snRNP:Snurportin complex formation"
xref: Reactome:488014 "snRNP Assembly"
xref: Reactome:506002 "snRNA Cap hypermethylation"
xref: Reactome:506003 "snRNP complex assembly"
xref: Reactome:506007 "snRNP:Snurportin complex formation"
xref: Reactome:508046 "snRNP Assembly"
xref: Reactome:516663 "snRNA Cap hypermethylation"
xref: Reactome:516664 "snRNP complex assembly"
xref: Reactome:516668 "snRNP:Snurportin complex formation"
xref: Reactome:517848 "snRNP Assembly"
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0000388
name: spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
namespace: biological_process
alt_id: GO:0000396
alt_id: GO:0000397
def: "Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11)." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents formation of the A1 complex (yeast) or the B2 complex (mammalian).
synonym: "3'-splice site cleavage, exon ligation" BROAD []
synonym: "spliceosomal A1 complex biosynthesis" NARROW []
synonym: "spliceosomal A1 complex formation" NARROW []
synonym: "spliceosomal B2 complex biosynthesis" NARROW []
synonym: "spliceosomal B2 complex formation" NARROW []
synonym: "U12-type spliceosome conformational change to release U4atac and U11" NARROW []
synonym: "U2-type spliceosome conformational change to release U4 and U1" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation

[Term]
id: GO:0000389
name: nuclear mRNA 3'-splice site recognition
namespace: biological_process
alt_id: GO:0000382
alt_id: GO:0000383
def: "Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome." [GOC:krc, ISBN:0879695897]
synonym: "U12-type nuclear mRNA 3'-splice site recognition" NARROW []
synonym: "U2-type nuclear mRNA 3'-splice site recognition" NARROW []
is_a: GO:0006376 ! mRNA splice site selection

[Term]
id: GO:0000390
name: spliceosome disassembly
namespace: biological_process
alt_id: GO:0000391
alt_id: GO:0000392
def: "Disassembly of the spliceosome with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure." [GOC:krc, ISBN:0879695897]
synonym: "spliceosome complex disassembly" EXACT []
synonym: "U12-type spliceosome disassembly" NARROW []
synonym: "U2-type spliceosome disassembly" NARROW []
is_a: GO:0032988 ! ribonucleoprotein complex disassembly
relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0000393
name: spliceosomal conformational changes to generate catalytic conformation
namespace: biological_process
def: "Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation." [GOC:krc]
synonym: "3'-splice site cleavage, exon ligation" BROAD []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0000394
name: RNA splicing, via endonucleolytic cleavage and ligation
namespace: biological_process
def: "Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897]
comment: Note that while typically associated with tRNA splicing, this mechanism of splicing is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis.
subset: gosubset_prok
synonym: "mRNA splicing" BROAD []
is_a: GO:0008380 ! RNA splicing

[Term]
id: GO:0000395
name: nuclear mRNA 5'-splice site recognition
namespace: biological_process
alt_id: GO:0000368
alt_id: GO:0000369
def: "Recognition of the intron 5'-splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]
comment: Note that this step represents formation of the Commitment Complex (CC, in yeast) or the E complex (mammalian).
synonym: "nuclear mRNA 5' splice site recognition" EXACT []
synonym: "spliceosomal CC complex biosynthesis" NARROW []
synonym: "spliceosomal CC complex formation" NARROW []
synonym: "spliceosomal commitment complex biosynthesis" NARROW []
synonym: "spliceosomal commitment complex formation" NARROW []
synonym: "spliceosomal E complex biosynthesis" NARROW []
synonym: "spliceosomal E complex formation" NARROW []
synonym: "U12-type nuclear mRNA 5' splice site recognition" NARROW []
synonym: "U12-type nuclear mRNA 5'-splice site recognition" NARROW []
synonym: "U2-type nuclear mRNA 5' splice site recognition" NARROW []
synonym: "U2-type nuclear mRNA 5'-splice site recognition" NARROW []
is_a: GO:0006376 ! mRNA splice site selection
relationship: part_of GO:0045292 ! nuclear mRNA cis splicing, via spliceosome

[Term]
id: GO:0000398
name: nuclear mRNA splicing, via spliceosome
namespace: biological_process
alt_id: GO:0006374
alt_id: GO:0006375
def: "The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0879695897]
comment: Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron.
synonym: "mRNA splicing" BROAD []
synonym: "nuclear mRNA splicing via U12-type spliceosome" NARROW []
synonym: "nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "pre-mRNA splicing" BROAD []
synonym: "splicing AT-AC intron" RELATED []
synonym: "splicing GT-AG intron" RELATED []
xref: Reactome:448866 "mRNA Splicing"
xref: Reactome:469983 "mRNA Splicing"
xref: Reactome:487689 "mRNA Splicing"
xref: Reactome:507640 "mRNA Splicing"
xref: Reactome:517603 "mRNA Splicing"
xref: Reactome:526452 "mRNA Splicing"
xref: Reactome:536633 "mRNA Splicing"
xref: Reactome:542360 "mRNA Splicing"
xref: Reactome:547705 "mRNA Splicing"
xref: Reactome:557908 "mRNA Splicing"
xref: Reactome:568519 "mRNA Splicing"
xref: Reactome:581730 "mRNA Splicing"
xref: Reactome:585854 "mRNA Splicing"
xref: Reactome:592633 "mRNA Splicing"
xref: Reactome:595428 "mRNA Splicing"
xref: Reactome:72172 "mRNA Splicing"
is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
is_a: GO:0006397 ! mRNA processing

[Term]
id: GO:0000399
name: cellular bud neck septin structure
namespace: cellular_component
def: "Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle." [GOC:krc]
is_a: GO:0032155 ! cell division site part
relationship: part_of GO:0005935 ! cellular bud neck

[Term]
id: GO:0000400
name: four-way junction DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464]
synonym: "forked DNA binding" BROAD []
synonym: "Holliday junction binding" EXACT []
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0000401
name: open form four-way junction DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over." [GOC:krc, ISBN:0815332181, PMID:15563464]
synonym: "open form Holliday junction binding" EXACT []
is_a: GO:0000400 ! four-way junction DNA binding

[Term]
id: GO:0000402
name: crossed form four-way junction DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands." [GOC:krc, ISBN:0815332181, PMID:15563464]
synonym: "crossed form Holliday junction binding" EXACT []
is_a: GO:0000400 ! four-way junction DNA binding

[Term]
id: GO:0000403
name: Y-form DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end." [GOC:elh, PMID:16781730]
synonym: "forked DNA binding" BROAD []
synonym: "splayed Y-form DNA binding" EXACT []
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0000404
name: loop DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration." [GOC:elh, PMID:16781730]
is_a: GO:0000217 ! DNA secondary structure binding
is_a: GO:0032135 ! DNA insertion or deletion binding

[Term]
id: GO:0000405
name: bubble DNA binding
namespace: molecular_function
def: "Interacting selective with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA." [GOC:elh, PMID:16781730]
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0000406
name: double-strand/single-strand DNA junction binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA." [GOC:elh, PMID:16781730]
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0000407
name: pre-autophagosomal structure
namespace: cellular_component
def: "A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655]
synonym: "isolation membrane" RELATED []
synonym: "PAS" EXACT []
synonym: "perivacuolar space" NARROW []
synonym: "phagophore assembly site" RELATED []
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000408
name: EKC/KEOPS protein complex
namespace: cellular_component
def: "A protein complex proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p." [GOC:elh, PMID:16564010, PMID:16874308]
synonym: "Endopeptidase-like Kinase Chromatin-associated protein complex" EXACT []
synonym: "Kinase, putative Endopeptidase and Other Proteins of Small size protein complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000409
name: regulation of transcription by galactose
namespace: biological_process
def: "Any process involving galactose that modulates the frequency, rate or extent or transcription." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0045990 ! regulation of transcription by carbon catabolites

[Term]
id: GO:0000410
name: negative regulation of transcription by galactose
namespace: biological_process
def: "Any process involving galactose that stops, prevents or reduces the rate of transcription." [GOC:mah]
synonym: "down regulation of transcription by galactose" EXACT []
synonym: "down-regulation of transcription by galactose" EXACT []
synonym: "downregulation of transcription by galactose" EXACT []
synonym: "inhibition of transcription by galactose" NARROW []
is_a: GO:0000409 ! regulation of transcription by galactose
is_a: GO:0045013 ! negative regulation of transcription by carbon catabolites

[Term]
id: GO:0000411
name: positive regulation of transcription by galactose
namespace: biological_process
def: "Any process involving galactose that activates or increases the rate of transcription." [GOC:go_curators]
synonym: "activation of transcription by galactose" NARROW []
synonym: "stimulation of transcription by galactose" NARROW []
synonym: "up regulation of transcription by galactose" EXACT []
synonym: "up-regulation of transcription by galactose" EXACT []
synonym: "upregulation of transcription by galactose" EXACT []
is_a: GO:0000409 ! regulation of transcription by galactose
is_a: GO:0045991 ! positive regulation of transcription by carbon catabolites

[Term]
id: GO:0000412
name: histone peptidyl-prolyl isomerization
namespace: biological_process
def: "The modification of a histone by cis-trans isomerization of a proline residue." [GOC:krc]
synonym: "histone proline isomerization" EXACT []
is_a: GO:0000413 ! protein peptidyl-prolyl isomerization
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0000413
name: protein peptidyl-prolyl isomerization
namespace: biological_process
def: "The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570]
synonym: "protein proline isomerization" EXACT []
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0000414
name: regulation of histone H3-K36 methylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc]
is_a: GO:0031060 ! regulation of histone methylation
relationship: regulates GO:0010452 ! histone H3-K36 methylation

[Term]
id: GO:0000415
name: negative regulation of histone H3-K36 methylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc]
synonym: "down regulation of histone H3-K36 methylation" EXACT []
synonym: "down-regulation of histone H3-K36 methylation" EXACT []
synonym: "downregulation of histone H3-K36 methylation" EXACT []
synonym: "inhibition of histone H3-K36 methylation" NARROW []
is_a: GO:0000414 ! regulation of histone H3-K36 methylation
is_a: GO:0031061 ! negative regulation of histone methylation
relationship: negatively_regulates GO:0010452 ! histone H3-K36 methylation

[Term]
id: GO:0000416
name: positive regulation of histone H3-K36 methylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc]
synonym: "activation of histone H3-K36 methylation" NARROW []
synonym: "stimulation of histone H3-K36 methylation" NARROW []
synonym: "up regulation of histone H3-K36 methylation" EXACT []
synonym: "up-regulation of histone H3-K36 methylation" EXACT []
synonym: "upregulation of histone H3-K36 methylation" EXACT []
is_a: GO:0000414 ! regulation of histone H3-K36 methylation
is_a: GO:0031062 ! positive regulation of histone methylation
relationship: positively_regulates GO:0010452 ! histone H3-K36 methylation

[Term]
id: GO:0000417
name: HIR complex
namespace: cellular_component
def: "A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p." [GOC:elh, GOC:mah, PMID:16303565, PMID:17180700]
is_a: GO:0005678 ! chromatin assembly complex

[Term]
id: GO:0000418
name: DNA-directed RNA polymerase IV complex
namespace: cellular_component
def: "RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants. In addition to RNA polymerases I, II, and III, the essential RNA polymerases present in all eukaryotes, plants have two additional nuclear RNA polymerases, Pol IV and Pol V, that play nonredundant roles in siRNA-directed DNA methylation and gene silencing. Pol IV is required for siRNA production and Pol V is required for generating noncoding transcripts at target loci. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984, PMID:19110459]
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex

[Term]
id: GO:0000419
name: DNA-directed RNA polymerase IVb complex
namespace: cellular_component
def: "RNA polymerase IVb is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:16140984]
is_a: GO:0000418 ! DNA-directed RNA polymerase IV complex

[Term]
id: GO:0000420
name: DNA-directed RNA polymerase IVa complex
namespace: cellular_component
def: "RNA polymerase IVa is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVb, while the largest subunit is found only in the IVa complex. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984]
is_a: GO:0000418 ! DNA-directed RNA polymerase IV complex

[Term]
id: GO:0000421
name: autophagic vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an autophagic vacuole, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:isa_complete]
synonym: "autophagosome membrane" EXACT []
is_a: GO:0005774 ! vacuolar membrane
relationship: part_of GO:0005776 ! autophagic vacuole

[Term]
id: GO:0000422
name: mitochondrion degradation
namespace: biological_process
def: "The process by which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions, autophagy of mitochondria." [PMID:15798367]
synonym: "mitophagy" EXACT []
xref: Wikipedia:Autophagy_(cellular)#Selective_autophagy
xref: Wikipedia:Mitophagy
is_a: GO:0006914 ! autophagy

[Term]
id: GO:0000423
name: macromitophagy
namespace: biological_process
def: "Degradation of a mitochondrion by macroautophagy." [PMID:15798367]
is_a: GO:0000422 ! mitochondrion degradation
is_a: GO:0016236 ! macroautophagy

[Term]
id: GO:0000424
name: micromitophagy
namespace: biological_process
def: "Degradation of a mitochondrion by microautophagy." [PMID:15798367]
is_a: GO:0000422 ! mitochondrion degradation
is_a: GO:0016237 ! microautophagy

[Term]
id: GO:0000425
name: macropexophagy
namespace: biological_process
def: "Degradation of a peroxisome by macropexophagy." [PMID:12914914, PMID:16973210]
is_a: GO:0016236 ! macroautophagy
is_a: GO:0030242 ! peroxisome degradation

[Term]
id: GO:0000426
name: micropexophagy
namespace: biological_process
def: "Degradation of a peroxisome by micropexophagy." [PMID:12914914, PMID:16973210]
is_a: GO:0016237 ! microautophagy
is_a: GO:0030242 ! peroxisome degradation

[Term]
id: GO:0000427
name: plastid-encoded plastid RNA polymerase complex
namespace: cellular_component
def: "An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition." [GOC:krc, GOC:mah, GOC:pj]
is_a: GO:0000428 ! DNA-directed RNA polymerase complex
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0000428
name: DNA-directed RNA polymerase complex
namespace: cellular_component
def: "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc]
is_a: GO:0030880 ! RNA polymerase complex

[Term]
id: GO:0000429
name: regulation of transcription from RNA polymerase II promoter by carbon catabolites
namespace: biological_process
def: "Any process involving carbon catabolites that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0045990 ! regulation of transcription by carbon catabolites

[Term]
id: GO:0000430
name: regulation of transcription from RNA polymerase II promoter by glucose
namespace: biological_process
def: "Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc]
is_a: GO:0000429 ! regulation of transcription from RNA polymerase II promoter by carbon catabolites
is_a: GO:0046015 ! regulation of transcription by glucose

[Term]
id: GO:0000431
name: regulation of transcription from RNA polymerase II promoter by galactose
namespace: biological_process
def: "Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc]
is_a: GO:0000409 ! regulation of transcription by galactose
is_a: GO:0000429 ! regulation of transcription from RNA polymerase II promoter by carbon catabolites

[Term]
id: GO:0000432
name: positive regulation of transcription from RNA polymerase II promoter by glucose
namespace: biological_process
def: "Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "activation of transcription from RNA polymerase II promoter by glucose" NARROW []
synonym: "stimulation of transcription from RNA polymerase II promoter by glucose" NARROW []
synonym: "up regulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "up-regulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "upregulation of transcription from RNA polymerase II promoter by glucose" EXACT []
is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose
is_a: GO:0000436 ! positive regulation of transcription from RNA polymerase II promoter by carbon catabolites
is_a: GO:0046016 ! positive regulation of transcription by glucose

[Term]
id: GO:0000433
name: negative regulation of transcription from RNA polymerase II promoter by glucose
namespace: biological_process
def: "Any process involving glucose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "down regulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter by glucose" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter by glucose" NARROW []
is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose
is_a: GO:0000437 ! negative regulation of transcription from RNA polymerase II promoter by carbon catabolites
is_a: GO:0045014 ! negative regulation of transcription by glucose

[Term]
id: GO:0000434
name: negative regulation of transcription from RNA polymerase II promoter by galactose
namespace: biological_process
def: "Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "down regulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter by galactose" NARROW []
is_a: GO:0000410 ! negative regulation of transcription by galactose
is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose
is_a: GO:0000437 ! negative regulation of transcription from RNA polymerase II promoter by carbon catabolites

[Term]
id: GO:0000435
name: positive regulation of transcription from RNA polymerase II promoter by galactose
namespace: biological_process
def: "Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "activation of transcription from RNA polymerase II promoter by galactose" NARROW []
synonym: "stimulation of transcription from RNA polymerase II promoter by galactose" NARROW []
synonym: "up regulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "up-regulation of transcription from RNA polymerase II promoter by galactose" EXACT []
synonym: "upregulation of transcription from RNA polymerase II promoter by galactose" EXACT []
is_a: GO:0000411 ! positive regulation of transcription by galactose
is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose
is_a: GO:0000436 ! positive regulation of transcription from RNA polymerase II promoter by carbon catabolites

[Term]
id: GO:0000436
name: positive regulation of transcription from RNA polymerase II promoter by carbon catabolites
namespace: biological_process
def: "Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "activation of transcription from RNA polymerase II promoter by carbon catabolites" NARROW []
synonym: "stimulation of transcription from RNA polymerase II promoter by carbon catabolites" NARROW []
synonym: "up regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT []
synonym: "up-regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT []
synonym: "upregulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT []
is_a: GO:0000429 ! regulation of transcription from RNA polymerase II promoter by carbon catabolites
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter

[Term]
id: GO:0000437
name: negative regulation of transcription from RNA polymerase II promoter by carbon catabolites
namespace: biological_process
def: "Any process involving carbon catabolites that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc]
synonym: "down regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter by carbon catabolites" NARROW []
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0000429 ! regulation of transcription from RNA polymerase II promoter by carbon catabolites

[Term]
id: GO:0000438
name: core TFIIH complex portion of holo TFIIH complex
namespace: cellular_component
def: "The core TFIIH complex when it is part of the general transcription factor TFIIH. In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015]
is_a: GO:0000439 ! core TFIIH complex
is_a: GO:0044451 ! nucleoplasm part
relationship: part_of GO:0000443 ! SSL2-core TFIIH complex portion of holo TFIIH complex

[Term]
id: GO:0000439
name: core TFIIH complex
namespace: cellular_component
def: "The 5 subunit core of TFIIH that has tightly associated subunits and is found in both the general transcription factor holo-TFIIH and in the nucleotide-excision repair factor 3 complex. In S. cerevisiae, it is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4. In humans, it is composed of XPD, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015]
is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex
relationship: part_of GO:0000441 ! SSL2-core TFIIH complex

[Term]
id: GO:0000440
name: core TFIIH complex portion of NEF3 complex
namespace: cellular_component
def: "The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015]
is_a: GO:0000439 ! core TFIIH complex
relationship: part_of GO:0000442 ! SSL2-core TFIIH complex portion of NEF3 complex

[Term]
id: GO:0000441
name: SSL2-core TFIIH complex
namespace: cellular_component
def: "A complex which is part of both the general transcription factor TFIIH and the nucleotide-excision repair factor 3 complex. It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, more loosely associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015]
subset: goslim_pir
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0000442
name: SSL2-core TFIIH complex portion of NEF3 complex
namespace: cellular_component
def: "The SSL2-core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015]
is_a: GO:0000441 ! SSL2-core TFIIH complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex

[Term]
id: GO:0000443
name: SSL2-core TFIIH complex portion of holo TFIIH complex
namespace: cellular_component
def: "The SSL2-core TFIIH complex when it is part of the general transcription factor TFIIH. It is composed of the tightly associated five subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015]
is_a: GO:0000441 ! SSL2-core TFIIH complex
is_a: GO:0044451 ! nucleoplasm part
relationship: part_of GO:0005675 ! holo TFIIH complex

[Term]
id: GO:0000444
name: MIS12/MIND type complex
namespace: cellular_component
def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1." [GOC:krc, PMID:14633972, PMID:16585270]
synonym: "Mis12 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000777 ! condensed chromosome kinetochore

[Term]
id: GO:0000445
name: THO complex part of transcription export complex
namespace: cellular_component
def: "The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]
synonym: "THO complex part of TREX complex" EXACT []
is_a: GO:0000347 ! THO complex
relationship: part_of GO:0000346 ! transcription export complex

[Term]
id: GO:0000446
name: nucleoplasmic THO complex
namespace: cellular_component
def: "The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072]
is_a: GO:0000347 ! THO complex
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0000447
name: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
synonym: "endonucleolytic cleavage at A2" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000448
name: cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
alt_id: GO:0000490
def: "Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
synonym: "cleavage at C2" RELATED []
synonym: "cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" EXACT []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000449
name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
namespace: biological_process
def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0000478 ! endonucleolytic cleavages during rRNA processing

[Term]
id: GO:0000450
name: cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species." [GOC:curators]
is_a: GO:0000478 ! endonucleolytic cleavages during rRNA processing

[Term]
id: GO:0000451
name: rRNA 2'-O-methylation
namespace: biological_process
def: "The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"]
is_a: GO:0031167 ! rRNA methylation

[Term]
id: GO:0000452
name: snoRNA guided rRNA 2'-O-methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"]
synonym: "snoRNA guided rRNA 2'-O-ribose methylation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000451 ! rRNA 2'-O-methylation

[Term]
id: GO:0000453
name: enzyme-directed rRNA 2'-O-methylation
namespace: biological_process
def: "The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"]
is_a: GO:0000451 ! rRNA 2'-O-methylation

[Term]
id: GO:0000454
name: snoRNA guided rRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"]
is_a: GO:0031118 ! rRNA pseudouridine synthesis

[Term]
id: GO:0000455
name: enzyme-directed rRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"]
is_a: GO:0031118 ! rRNA pseudouridine synthesis

[Term]
id: GO:0000456
name: dimethylation during SSU-rRNA biogenesis
namespace: biological_process
def: "Dimethyation of the N6 amino groups of two consecutive adenosine residues near the 3'-end of the SSU rRNA. This process has been conserved from bacteria to eukaryotes." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"]
is_a: GO:0031167 ! rRNA methylation

[Term]
id: GO:0000457
name: endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
namespace: biological_process
def: "Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
relationship: part_of GO:0002109 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)

[Term]
id: GO:0000458
name: endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
namespace: biological_process
def: "Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)
relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)

[Term]
id: GO:0000459
name: exonucleolytic trimming during rRNA processing
namespace: biological_process
def: "Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule." [GOC:curators]
is_a: GO:0000469 ! cleavages during rRNA processing

[Term]
id: GO:0000460
name: maturation of 5.8S rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000461
name: endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:krc, PMID:10690410]
synonym: "endonucleolytic cleavage at site D" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
is_a: GO:0031125 ! rRNA 3'-end processing
relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000462
name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0000463
name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000470 ! maturation of LSU-rRNA

[Term]
id: GO:0000464
name: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs." [GOC:krc, PMID:10690410]
synonym: "endonucleolytic cleavage at A3" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000465
name: exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]
is_a: GO:0000459 ! exonucleolytic trimming during rRNA processing
is_a: GO:0000967 ! rRNA 5'-end processing
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000466
name: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
is_a: GO:0000460 ! maturation of 5.8S rRNA

[Term]
id: GO:0000467
name: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]
is_a: GO:0000459 ! exonucleolytic trimming during rRNA processing
is_a: GO:0031125 ! rRNA 3'-end processing
relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000468
name: generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410]
synonym: "processing at B2" NARROW []
is_a: GO:0031125 ! rRNA 3'-end processing
relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000469
name: cleavages during rRNA processing
namespace: biological_process
def: "Any cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000470
name: maturation of LSU-rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000471
name: endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events." [GOC:krc, PMID:10690410]
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000472
name: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:curators, PMID:10690410]
synonym: "endonucleolytic cleavage at A1" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
is_a: GO:0000967 ! rRNA 5'-end processing
relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000473
name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000470 ! maturation of LSU-rRNA

[Term]
id: GO:0000474
name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0000475
name: maturation of 2S rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000476
name: maturation of 4.5S rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000477
name: generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410]
synonym: "processing at C1" NARROW []
is_a: GO:0000469 ! cleavages during rRNA processing
is_a: GO:0000967 ! rRNA 5'-end processing
relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000478
name: endonucleolytic cleavages during rRNA processing
namespace: biological_process
def: "Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA." [GOC:krc, PMID:10690410]
is_a: GO:0000469 ! cleavages during rRNA processing

[Term]
id: GO:0000479
name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae." [GOC:curators, PMID:10690410]
is_a: GO:0000478 ! endonucleolytic cleavages during rRNA processing

[Term]
id: GO:0000480
name: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable." [GOC:curators, PMID:10690410, PMID:15282326]
synonym: "endonucleolytic cleavage at A-prime" NARROW [PMID:15282326]
synonym: "endonucleolytic cleavage at A0" NARROW []
is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

[Term]
id: GO:0000481
name: maturation of 5S rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule." [GOC:curators]
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0000482
name: maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000481 ! maturation of 5S rRNA

[Term]
id: GO:0000483
name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species." [GOC:curators]
is_a: GO:0000478 ! endonucleolytic cleavages during rRNA processing

[Term]
id: GO:0000484
name: cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000474 ! maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)

[Term]
id: GO:0000485
name: cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488]
is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000473 ! maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000475 ! maturation of 2S rRNA

[Term]
id: GO:0000486
name: cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488]
is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
relationship: part_of GO:0000475 ! maturation of 2S rRNA
relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)

[Term]
id: GO:0000487
name: maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000460 ! maturation of 5.8S rRNA

[Term]
id: GO:0000488
name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000470 ! maturation of LSU-rRNA

[Term]
id: GO:0000489
name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0000491
name: small nucleolar ribonucleoprotein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc]
synonym: "snoRNP assembly" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly

[Term]
id: GO:0000492
name: box C/D snoRNP assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc]
synonym: "box C/D small nucleolar ribonucleoprotein complex assembly" EXACT []
is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly

[Term]
id: GO:0000493
name: box H/ACA snoRNP assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc, PMID:12515383]
synonym: "box H/ACA small nucleolar ribonucleoprotein complex assembly" EXACT []
is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly

[Term]
id: GO:0000494
name: box C/D snoRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a box C/D snoRNA molecule." [GOC:krc]
synonym: "box C/D snoRNA 3' end processing" EXACT []
is_a: GO:0031126 ! snoRNA 3'-end processing
is_a: GO:0034963 ! box C/D snoRNA processing

[Term]
id: GO:0000495
name: box H/ACA snoRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule." [GOC:krc]
synonym: "box H/ACA snoRNA 3' end processing" EXACT []
is_a: GO:0031126 ! snoRNA 3'-end processing
is_a: GO:0034964 ! box H/ACA snoRNA processing

[Term]
id: GO:0000496
name: base pairing
namespace: molecular_function
def: "Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target nucleic acid molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other nucleic acid molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
xref: Wikipedia:Base_pair
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0000497
name: base pairing with DNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000496 ! base pairing
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0000498
name: base pairing with RNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with ribonucleic acid (RNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target RNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000496 ! base pairing
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0000499
name: base pairing with mRNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with messenger ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target mRNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000498 ! base pairing with RNA

[Term]
id: GO:0000500
name: RNA polymerase I upstream activating factor complex
namespace: cellular_component
def: "A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p." [PMID:11500378]
synonym: "RNA polymerase I upstream activation factor complex" EXACT []
synonym: "UAF" EXACT []
is_a: GO:0000120 ! RNA polymerase I transcription factor complex

[Term]
id: GO:0000501
name: flocculation via cell wall protein-carbohydrate interaction
namespace: biological_process
def: "Mannose-sensitive, nonsexual aggregation of cells mediated by protein-carbohydrate (flocculin-mannan) interaction present in the cell wall. This process is pH- and calcium-dependent and reversible. An example of this process is found in Saccharomyces cerevisiae." [DOI:10.1016/S0963-9969(99)00021-6, GOC:sgd_curators]
subset: gosubset_prok
is_a: GO:0000128 ! flocculation

[Term]
id: GO:0000502
name: proteasome complex
namespace: cellular_component
def: "A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb]
subset: goslim_pir
synonym: "26S proteasome" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0000504
name: proteasome regulatory particle (sensu Bacteria)
namespace: cellular_component
def: "OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:rb]
comment: This term was made obsolete because there is no ubiquitin in bacteria and they do not have proteasome regulatory particles. Instead they have proteasome-activating nucleotidase.
synonym: "26S proteasome" NARROW []
is_obsolete: true

[Term]
id: GO:0000506
name: glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast." [GOC:kp, GOC:rb, PMID:10944123, PMID:15163411]
comment: Note that this term should not be confused with 'GPI-anchor transamidase complex ; GO:0042765', which represents a distinct complex with a different catalytic activity.
synonym: "GPI-GlcNAc transferase complex" EXACT []
synonym: "GPI-GnT complex" EXACT []
synonym: "GPI-N-acetylglucosaminyltransferase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0000578
name: embryonic axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb]
synonym: "embryonic axis determination" RELATED []
is_a: GO:0009798 ! axis specification
is_a: GO:0009880 ! embryonic pattern specification

[Term]
id: GO:0000700
name: mismatch base pair DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:9224623]
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0000701
name: purine-specific mismatch base pair DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [GOC:elh, PMID:9224623]
synonym: "A/G-specific adenine DNA glycosylase activity" NARROW []
xref: EC:3.2.2.-
is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity

[Term]
id: GO:0000702
name: oxidized base lesion DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296]
subset: gosubset_prok
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0000703
name: oxidized pyrimidine base lesion DNA N-glycosylase activity
namespace: molecular_function
alt_id: GO:0019004
def: "Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:11554296]
comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
subset: gosubset_prok
synonym: "bifunctional DNA glycosylase" BROAD []
synonym: "DNA glycosylase/AP-lyase" BROAD []
synonym: "DNA glycosylase/beta-lyase" BROAD []
synonym: "endodeoxyribonuclease III" RELATED []
synonym: "endonuclease III" RELATED []
synonym: "endonuclease VIII activity" RELATED []
synonym: "pyrimidine-specific oxidized base lesion DNA N-glycosylase activity" RELATED []
xref: Reactome:25087 "oxidized pyrimidine base lesion DNA N-glycosylase activity"
is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity
is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity

[Term]
id: GO:0000704
name: pyrimidine dimer DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:9224623]
is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity
is_a: GO:0004520 ! endodeoxyribonuclease activity
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0000705
name: achiasmate meiosis I
namespace: biological_process
def: "The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata." [GOC:elh, GOC:sart, PMID:10690419]
is_a: GO:0007127 ! meiosis I

[Term]
id: GO:0000706
name: meiotic DNA double-strand break processing
namespace: biological_process
def: "The cell cycle process whereby the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324]
is_a: GO:0000729 ! DNA double-strand break processing
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0000707
name: meiotic DNA recombinase assembly
namespace: biological_process
def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA." [GOC:elh, PMID:11459983]
is_a: GO:0000730 ! DNA recombinase assembly
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0000708
name: meiotic strand invasion
namespace: biological_process
def: "The cell cycle process whereby the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis." [GOC:elh, PMID:10915877]
synonym: "meiotic D-loop biosynthesis" RELATED []
synonym: "meiotic D-loop formation" RELATED []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0042148 ! strand invasion
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0000709
name: meiotic joint molecule formation
namespace: biological_process
def: "The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA." [GOC:elh, PMID:8521495]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0000710
name: meiotic mismatch repair
namespace: biological_process
def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855]
is_a: GO:0006298 ! mismatch repair
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0000711
name: meiotic DNA repair synthesis
namespace: biological_process
def: "During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template." [GOC:elh, PMID:9334324]
is_a: GO:0000731 ! DNA synthesis during DNA repair
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0000712
name: resolution of meiotic recombination intermediates
namespace: biological_process
def: "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053]
synonym: "crossover biosynthesis" NARROW []
synonym: "crossover formation" NARROW []
synonym: "formation of chiasmata" NARROW []
synonym: "homologous chromosome separation at meiosis I" EXACT []
synonym: "meiotic homologous chromosome separation" RELATED []
synonym: "resolution of meiotic joint molecules as recombinants" NARROW [GOC:elh, GOC:mah]
is_a: GO:0051307 ! meiotic chromosome separation
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0000713
name: meiotic heteroduplex formation
namespace: biological_process
def: "During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:9334324]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0030491 ! heteroduplex formation
relationship: part_of GO:0006310 ! DNA recombination
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0000714
name: meiotic strand displacement
namespace: biological_process
def: "The cell cycle process whereby the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis." [GOC:elh, PMID:10357855]
is_a: GO:0000732 ! strand displacement
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0000715
name: nucleotide-excision repair, DNA damage recognition
namespace: biological_process
def: "The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix." [GOC:elh, PMID:10197977]
subset: gosubset_prok
synonym: "pyrimidine-dimer repair, DNA damage recognition" NARROW []
xref: Reactome:449311 "DNA Damage Recognition in GG-NER"
xref: Reactome:470430 "DNA Damage Recognition in GG-NER"
xref: Reactome:488109 "DNA Damage Recognition in GG-NER"
xref: Reactome:508079 "DNA Damage Recognition in GG-NER"
xref: Reactome:517925 "DNA Damage Recognition in GG-NER"
xref: Reactome:526753 "DNA Damage Recognition in GG-NER"
xref: Reactome:531516 "DNA Damage Recognition in GG-NER"
xref: Reactome:536908 "DNA Damage Recognition in GG-NER"
xref: Reactome:542656 "DNA Damage Recognition in GG-NER"
xref: Reactome:547970 "DNA Damage Recognition in GG-NER"
xref: Reactome:552548 "DNA Damage Recognition in GG-NER"
xref: Reactome:558172 "DNA Damage Recognition in GG-NER"
xref: Reactome:568801 "DNA Damage Recognition in GG-NER"
xref: Reactome:582002 "DNA Damage Recognition in GG-NER"
xref: Reactome:592914 "DNA Damage Recognition in GG-NER"
xref: Reactome:73940 "DNA Damage Recognition in GG-NER"
is_a: GO:0051276 ! chromosome organization
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0000716
name: transcription-coupled nucleotide-excision repair, DNA damage recognition
namespace: biological_process
def: "The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway." [GOC:elh, PMID:10197977]
subset: gosubset_prok
synonym: "pyrimidine-dimer repair, DNA damage recognition" NARROW []
xref: Reactome:109972 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:446553 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:467883 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:485762 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:505657 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:516442 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:525443 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:530659 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:536055 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:541683 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:547121 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:551719 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:557233 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:567433 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:580534 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:585494 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:591938 "RNA Pol II is blocked by the lesion leading to reduced transcription"
xref: Reactome:595000 "RNA Pol II is blocked by the lesion leading to reduced transcription"
is_a: GO:0000715 ! nucleotide-excision repair, DNA damage recognition
relationship: part_of GO:0006283 ! transcription-coupled nucleotide-excision repair

[Term]
id: GO:0000717
name: nucleotide-excision repair, DNA duplex unwinding
namespace: biological_process
def: "The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage." [GOC:elh, PMID:10197977]
subset: gosubset_prok
xref: Reactome:439042 "Formation of open bubble structure in DNA by helicases"
xref: Reactome:461073 "Formation of open bubble structure in DNA by helicases"
xref: Reactome:479833 "Formation of open bubble structure in DNA by helicases"
xref: Reactome:499712 "Formation of open bubble structure in DNA by helicases"
xref: Reactome:513752 "Formation of open bubble structure in DNA by helicases"
xref: Reactome:522780 "Formation of open bubble structure in DNA by helicases"
xref: Reactome:529344 "Formation of open bubble structure in DNA by helicases"
xref: Reactome:534635 "Formation of open bubble structure in DNA by helicases"
xref: Reactome:540171 "Formation of open bubble structure in DNA by helicases"
xref: Reactome:545856 "Formation of open bubble structure in DNA by helicases"
xref: Reactome:550628 "Formation of open bubble structure in DNA by helicases"
xref: Reactome:555768 "Formation of open bubble structure in DNA by helicases"
xref: Reactome:565145 "Formation of open bubble structure in DNA by helicases"
xref: Reactome:577672 "Formation of open bubble structure in DNA by helicases"
xref: Reactome:590003 "Formation of open bubble structure in DNA by helicases"
xref: Reactome:73934 "Formation of open bubble structure in DNA by helicases"
is_a: GO:0032508 ! DNA duplex unwinding
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0000718
name: nucleotide-excision repair, DNA damage removal
namespace: biological_process
def: "The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage." [GOC:elh, PMID:10197977]
subset: gosubset_prok
xref: Reactome:448580 "Dual incision reaction in GG-NER"
xref: Reactome:469709 "Dual incision reaction in GG-NER"
xref: Reactome:487421 "Dual incision reaction in GG-NER"
xref: Reactome:507376 "Dual incision reaction in GG-NER"
xref: Reactome:517375 "Dual incision reaction in GG-NER"
xref: Reactome:526251 "Dual incision reaction in GG-NER"
xref: Reactome:531128 "Dual incision reaction in GG-NER"
xref: Reactome:536500 "Dual incision reaction in GG-NER"
xref: Reactome:542210 "Dual incision reaction in GG-NER"
xref: Reactome:547564 "Dual incision reaction in GG-NER"
xref: Reactome:552174 "Dual incision reaction in GG-NER"
xref: Reactome:557758 "Dual incision reaction in GG-NER"
xref: Reactome:568371 "Dual incision reaction in GG-NER"
xref: Reactome:581573 "Dual incision reaction in GG-NER"
xref: Reactome:592469 "Dual incision reaction in GG-NER"
xref: Reactome:73941 "Dual incision reaction in GG-NER"
is_a: GO:0006308 ! DNA catabolic process
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0000719
name: photoreactive repair
namespace: biological_process
def: "The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines." [GOC:elh, PMID:10915863]
subset: gosubset_prok
synonym: "pyrimidine-dimer repair by photolyase" NARROW []
is_a: GO:0006290 ! pyrimidine dimer repair

[Term]
id: GO:0000720
name: pyrimidine dimer repair by nucleotide-excision repair
namespace: biological_process
def: "The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [GOC:elh]
comment: Note that the repair of pyrimidine dimers by nucleotide excision repair involves the same gene products that are involved in general nucleotide excision repair. Consider also annotating to other children of the biological process term 'nucleotide-excision repair ; GO:0006289'.
subset: gosubset_prok
is_a: GO:0006289 ! nucleotide-excision repair
is_a: GO:0006290 ! pyrimidine dimer repair

[Term]
id: GO:0000721
name: (R,R)-butanediol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+." [EC:1.1.1.4]
subset: gosubset_prok
synonym: "(R)-2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "(R)-diacetyl reductase activity" EXACT [EC:1.1.1.4]
synonym: "1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "1-amino-2-propanol oxidoreductase activity" EXACT [EC:1.1.1.4]
synonym: "2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "aminopropanol oxidoreductase activity" EXACT [EC:1.1.1.4]
synonym: "butylene glycol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "butyleneglycol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "D-(-)-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "D-1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "D-1-amino-2-propanol:NAD(2) oxidoreductase activity" EXACT [EC:1.1.1.4]
synonym: "D-aminopropanol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "D-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4]
synonym: "diacetyl (acetoin) reductase activity" RELATED [EC:1.1.1.4]
xref: EC:1.1.1.4
xref: MetaCyc:RR-BUTANEDIOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0000722
name: telomere maintenance via recombination
namespace: biological_process
def: "Any recombinational process that contributes to the maintenance of proper telomeric length." [GOC:elh, PMID:11850777]
synonym: "telomerase-independent telomere maintenance" RELATED []
xref: Reactome:174411 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:174414 "Processive synthesis on the C-strand of the telomere"
xref: Reactome:174425 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:174427 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:174430 "Telomere C-strand synthesis initiation"
xref: Reactome:174437 "Removal of the Flap Intermediate from the C-strand"
xref: Reactome:174438 "Formation of the Flap Intermediate on the C-strand"
xref: Reactome:174439 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:174441 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand"
xref: Reactome:174444 "Formation of C-strand Okazaki fragments"
xref: Reactome:174445 "RPA binds to the Flap on the C-strand"
xref: Reactome:174446 "Removal of remaining Flap from the C-strand"
xref: Reactome:174447 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:174448 "Formation of Processive Complex on the C-strand of the telomere"
xref: Reactome:174451 "Recruitment of Dna2 endonuclease to the C strand"
xref: Reactome:174452 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:174456 "Joining of adjacent Okazaki fragments of the C-strand"
xref: Reactome:438884 "Formation of C-strand Okazaki fragments"
xref: Reactome:439048 "Formation of Processive Complex on the C-strand of the telomere"
xref: Reactome:439073 "Formation of the Flap Intermediate on the C-strand"
xref: Reactome:441333 "Joining of adjacent Okazaki fragments of the C-strand"
xref: Reactome:442036 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:446102 "Recruitment of Dna2 endonuclease to the C strand"
xref: Reactome:446492 "Removal of remaining Flap from the C-strand"
xref: Reactome:446496 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand"
xref: Reactome:446525 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:446527 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:446588 "RPA binds to the Flap on the C-strand"
xref: Reactome:447318 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:447323 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:449104 "Processive synthesis on the C-strand of the telomere"
xref: Reactome:449113 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:449271 "Removal of the Flap Intermediate from the C-strand"
xref: Reactome:449289 "Telomere C-strand synthesis initiation"
xref: Reactome:460877 "Formation of C-strand Okazaki fragments"
xref: Reactome:461079 "Formation of Processive Complex on the C-strand of the telomere"
xref: Reactome:461103 "Formation of the Flap Intermediate on the C-strand"
xref: Reactome:463137 "Joining of adjacent Okazaki fragments of the C-strand"
xref: Reactome:463739 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:467427 "Recruitment of Dna2 endonuclease to the C strand"
xref: Reactome:467815 "Removal of remaining Flap from the C-strand"
xref: Reactome:467819 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand"
xref: Reactome:467848 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:467850 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:467921 "RPA binds to the Flap on the C-strand"
xref: Reactome:468574 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:468579 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:470216 "Processive synthesis on the C-strand of the telomere"
xref: Reactome:470225 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:470391 "Removal of the Flap Intermediate from the C-strand"
xref: Reactome:470408 "Telomere C-strand synthesis initiation"
xref: Reactome:482208 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:485740 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:487977 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:499533 "Formation of C-strand Okazaki fragments"
xref: Reactome:499718 "Formation of Processive Complex on the C-strand of the telomere"
xref: Reactome:499743 "Formation of the Flap Intermediate on the C-strand"
xref: Reactome:502009 "Joining of adjacent Okazaki fragments of the C-strand"
xref: Reactome:502421 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:505208 "Recruitment of Dna2 endonuclease to the C strand"
xref: Reactome:505612 "Removal of remaining Flap from the C-strand"
xref: Reactome:505641 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:505643 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:506327 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:506332 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:507867 "Processive synthesis on the C-strand of the telomere"
xref: Reactome:507878 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:508031 "Removal of the Flap Intermediate from the C-strand"
xref: Reactome:508055 "Telomere C-strand synthesis initiation"
xref: Reactome:514792 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:516430 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:516432 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:516800 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:516805 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:517821 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:517909 "Telomere C-strand synthesis initiation"
xref: Reactome:523855 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:525431 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:525433 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:525710 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:525715 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:526652 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:526737 "Telomere C-strand synthesis initiation"
xref: Reactome:529306 "Formation of C-strand Okazaki fragments"
xref: Reactome:529349 "Formation of Processive Complex on the C-strand of the telomere"
xref: Reactome:529362 "Formation of the Flap Intermediate on the C-strand"
xref: Reactome:529824 "Joining of adjacent Okazaki fragments of the C-strand"
xref: Reactome:529889 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:530503 "Recruitment of Dna2 endonuclease to the C strand"
xref: Reactome:530640 "Removal of remaining Flap from the C-strand"
xref: Reactome:530647 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:530649 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:530799 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:530804 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:531397 "Processive synthesis on the C-strand of the telomere"
xref: Reactome:531405 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:531485 "Removal of the Flap Intermediate from the C-strand"
xref: Reactome:531501 "Telomere C-strand synthesis initiation"
xref: Reactome:535166 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:536043 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:536045 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:536180 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:536185 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:536823 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:536892 "Telomere C-strand synthesis initiation"
xref: Reactome:540135 "Formation of C-strand Okazaki fragments"
xref: Reactome:540175 "Formation of Processive Complex on the C-strand of the telomere"
xref: Reactome:540188 "Formation of the Flap Intermediate on the C-strand"
xref: Reactome:540690 "Joining of adjacent Okazaki fragments of the C-strand"
xref: Reactome:540767 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:541506 "Recruitment of Dna2 endonuclease to the C strand"
xref: Reactome:541664 "Removal of remaining Flap from the C-strand"
xref: Reactome:541671 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:541673 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:541829 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:541834 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:542528 "Processive synthesis on the C-strand of the telomere"
xref: Reactome:542534 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:542624 "Removal of the Flap Intermediate from the C-strand"
xref: Reactome:542640 "Telomere C-strand synthesis initiation"
xref: Reactome:545814 "Formation of C-strand Okazaki fragments"
xref: Reactome:545859 "Formation of Processive Complex on the C-strand of the telomere"
xref: Reactome:545872 "Formation of the Flap Intermediate on the C-strand"
xref: Reactome:546299 "Joining of adjacent Okazaki fragments of the C-strand"
xref: Reactome:546360 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:546947 "Recruitment of Dna2 endonuclease to the C strand"
xref: Reactome:547102 "Removal of remaining Flap from the C-strand"
xref: Reactome:547109 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:547111 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:547266 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:547271 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:547853 "Processive synthesis on the C-strand of the telomere"
xref: Reactome:547859 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:547940 "Removal of the Flap Intermediate from the C-strand"
xref: Reactome:547957 "Telomere C-strand synthesis initiation"
xref: Reactome:550584 "Formation of C-strand Okazaki fragments"
xref: Reactome:550632 "Formation of Processive Complex on the C-strand of the telomere"
xref: Reactome:550645 "Formation of the Flap Intermediate on the C-strand"
xref: Reactome:551044 "Joining of adjacent Okazaki fragments of the C-strand"
xref: Reactome:551128 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:551606 "Recruitment of Dna2 endonuclease to the C strand"
xref: Reactome:551700 "Removal of remaining Flap from the C-strand"
xref: Reactome:551707 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:551709 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:551845 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:551850 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:552425 "Processive synthesis on the C-strand of the telomere"
xref: Reactome:552436 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:552515 "Removal of the Flap Intermediate from the C-strand"
xref: Reactome:552529 "Telomere C-strand synthesis initiation"
xref: Reactome:556338 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:557218 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:557220 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:557371 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:557376 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:558091 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:558151 "Telomere C-strand synthesis initiation"
xref: Reactome:565108 "Formation of C-strand Okazaki fragments"
xref: Reactome:565148 "Formation of Processive Complex on the C-strand of the telomere"
xref: Reactome:565163 "Formation of the Flap Intermediate on the C-strand"
xref: Reactome:565964 "Joining of adjacent Okazaki fragments of the C-strand"
xref: Reactome:566093 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:567119 "Recruitment of Dna2 endonuclease to the C strand"
xref: Reactome:567408 "Removal of remaining Flap from the C-strand"
xref: Reactome:567421 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:567423 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:567719 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:567724 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:568689 "Processive synthesis on the C-strand of the telomere"
xref: Reactome:568695 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:568766 "Removal of the Flap Intermediate from the C-strand"
xref: Reactome:568781 "Telomere C-strand synthesis initiation"
xref: Reactome:577612 "Formation of C-strand Okazaki fragments"
xref: Reactome:577674 "Formation of Processive Complex on the C-strand of the telomere"
xref: Reactome:577689 "Formation of the Flap Intermediate on the C-strand"
xref: Reactome:578739 "Joining of adjacent Okazaki fragments of the C-strand"
xref: Reactome:578910 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:580133 "Recruitment of Dna2 endonuclease to the C strand"
xref: Reactome:580504 "Removal of remaining Flap from the C-strand"
xref: Reactome:580517 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:580519 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:580826 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:580831 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:581892 "Processive synthesis on the C-strand of the telomere"
xref: Reactome:581898 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:581969 "Removal of the Flap Intermediate from the C-strand"
xref: Reactome:581984 "Telomere C-strand synthesis initiation"
xref: Reactome:584788 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:585488 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:585490 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:585553 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:585973 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:586034 "Telomere C-strand synthesis initiation"
xref: Reactome:590720 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:591931 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:591933 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:592084 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:592089 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:592829 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:592890 "Telomere C-strand synthesis initiation"
xref: Reactome:594651 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere"
xref: Reactome:594988 "RFC binding displaces Pol Alpha on the C-strand of the telomere"
xref: Reactome:594990 "RFC dissociates after sliding clamp formation on the C-strand of the telomere"
xref: Reactome:595076 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere"
xref: Reactome:595081 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere"
xref: Reactome:595551 "Polymerase switching on the C-strand of the telomere"
xref: Reactome:595591 "Telomere C-strand synthesis initiation"
is_a: GO:0000723 ! telomere maintenance
is_a: GO:0006312 ! mitotic recombination

[Term]
id: GO:0000723
name: telomere maintenance
namespace: biological_process
def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831]
synonym: "regulation of telomere length" RELATED [GOC:dph, GOC:tb]
xref: Reactome:157579 "Telomere Maintenance"
xref: Reactome:171306 "Packaging Of Telomere Ends"
xref: Reactome:176702 "Disassociation of Processive Complex and Completed Telomere End"
xref: Reactome:436649 "Disassociation of Processive Complex and Completed Telomere End"
xref: Reactome:448788 "Telomere Maintenance"
xref: Reactome:458956 "Disassociation of Processive Complex and Completed Telomere End"
xref: Reactome:469903 "Telomere Maintenance"
xref: Reactome:487610 "Telomere Maintenance"
xref: Reactome:497987 "Disassociation of Processive Complex and Completed Telomere End"
xref: Reactome:507565 "Telomere Maintenance"
xref: Reactome:517824 "Telomere Maintenance"
xref: Reactome:526655 "Telomere Maintenance"
xref: Reactome:529037 "Disassociation of Processive Complex and Completed Telomere End"
xref: Reactome:531231 "Telomere Maintenance"
xref: Reactome:536600 "Telomere Maintenance"
xref: Reactome:539811 "Disassociation of Processive Complex and Completed Telomere End"
xref: Reactome:542326 "Telomere Maintenance"
xref: Reactome:545483 "Disassociation of Processive Complex and Completed Telomere End"
xref: Reactome:547666 "Telomere Maintenance"
xref: Reactome:550237 "Disassociation of Processive Complex and Completed Telomere End"
xref: Reactome:552251 "Telomere Maintenance"
xref: Reactome:557870 "Telomere Maintenance"
xref: Reactome:564406 "Disassociation of Processive Complex and Completed Telomere End"
xref: Reactome:568468 "Telomere Maintenance"
xref: Reactome:576713 "Disassociation of Processive Complex and Completed Telomere End"
xref: Reactome:581679 "Telomere Maintenance"
xref: Reactome:585976 "Telomere Maintenance"
xref: Reactome:592588 "Telomere Maintenance"
xref: Reactome:595554 "Telomere Maintenance"
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0032200 ! telomere organization
is_a: GO:0060249 ! anatomical structure homeostasis

[Term]
id: GO:0000724
name: double-strand break repair via homologous recombination
namespace: biological_process
alt_id: GO:0016924
def: "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855]
subset: gosubset_prok
synonym: "HDR" EXACT [GOC:vk]
synonym: "homologous recombinational repair" EXACT []
synonym: "homology-directed repair" EXACT [GOC:vk]
synonym: "HRR" EXACT []
synonym: "Rad51-dependent recombinational repair" EXACT [GOC:mah]
synonym: "Rhp51-dependent recombinational repair" EXACT []
xref: Reactome:448607 "Homologous Recombination Repair"
xref: Reactome:469736 "Homologous Recombination Repair"
xref: Reactome:487646 "Homologous Recombination Repair"
xref: Reactome:507622 "Homologous Recombination Repair"
xref: Reactome:517588 "Homologous Recombination Repair"
xref: Reactome:526450 "Homologous Recombination Repair"
xref: Reactome:531256 "Homologous Recombination Repair"
xref: Reactome:536631 "Homologous Recombination Repair"
xref: Reactome:542358 "Homologous Recombination Repair"
xref: Reactome:547703 "Homologous Recombination Repair"
xref: Reactome:552288 "Homologous Recombination Repair"
xref: Reactome:557904 "Homologous Recombination Repair"
xref: Reactome:568505 "Homologous Recombination Repair"
xref: Reactome:581716 "Homologous Recombination Repair"
xref: Reactome:585850 "Homologous Recombination Repair"
xref: Reactome:592630 "Homologous Recombination Repair"
xref: Reactome:595425 "Homologous Recombination Repair"
xref: Reactome:597360 "Homologous Recombination Repair"
xref: Reactome:598158 "Homologous Recombination Repair"
xref: Reactome:600681 "Homologous Recombination Repair"
xref: Reactome:602587 "Homologous Recombination Repair"
xref: Reactome:73888 "Homologous Recombination Repair"
is_a: GO:0000725 ! recombinational repair
is_a: GO:0006302 ! double-strand break repair

[Term]
id: GO:0000725
name: recombinational repair
namespace: biological_process
def: "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh]
subset: gosubset_prok
xref: Wikipedia:Recombinational_repair
is_a: GO:0006281 ! DNA repair
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0000726
name: non-recombinational repair
namespace: biological_process
def: "A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh]
subset: gosubset_prok
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0000727
name: double-strand break repair via break-induced replication
namespace: biological_process
def: "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855]
subset: gosubset_prok
is_a: GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:0000728
name: gene conversion at mating-type locus, DNA double-strand break formation
namespace: biological_process
def: "The site-specific endonucleolytic cleavage of DNA at the mating-type locus which initiates the conversion of one mating-type allele to another." [GOC:elh, PMID:7646483]
is_a: GO:0000737 ! DNA catabolic process, endonucleolytic
relationship: part_of GO:0007534 ! gene conversion at mating-type locus

[Term]
id: GO:0000729
name: DNA double-strand break processing
namespace: biological_process
def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." [PMID:10357855]
xref: Reactome:83897 "Resection of double-strand break ends"
is_a: GO:0000738 ! DNA catabolic process, exonucleolytic
relationship: part_of GO:0006302 ! double-strand break repair

[Term]
id: GO:0000730
name: DNA recombinase assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA." [PMID:10357855]
synonym: "Rad51 nucleoprotein filament formation" EXACT [GOC:elh, GOC:vw]
xref: Reactome:448862 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:469979 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:487684 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:507637 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:517599 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:526446 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:531257 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:536627 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:542354 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:547699 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:552284 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:557906 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:568517 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:581728 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:585852 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:592631 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:595421 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:597356 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:598154 "Assembly of the RAD51-ssDNA nucleoprotein complex"
xref: Reactome:76000 "Assembly of the RAD51-ssDNA nucleoprotein complex"
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing

[Term]
id: GO:0000731
name: DNA synthesis during DNA repair
namespace: biological_process
def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template." [PMID:10357855]
subset: gosubset_prok
synonym: "DNA repair synthesis" BROAD []
xref: Reactome:76011 "DNA repair synthesis"
is_a: GO:0006260 ! DNA replication
relationship: part_of GO:0006281 ! DNA repair

[Term]
id: GO:0000732
name: strand displacement
namespace: biological_process
def: "The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules." [PMID:10357855]
subset: gosubset_prok
xref: Reactome:83663 "Dissociation of the extended strands"
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006310 ! DNA recombination

[Term]
id: GO:0000733
name: DNA strand renaturation
namespace: biological_process
def: "The identification and annealing of complementary base pairs in single-strand DNA." [GOC:elh]
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing

[Term]
id: GO:0000734
name: gene conversion at mating-type locus, DNA repair synthesis
namespace: biological_process
def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template during gene conversion at the mating-type locus." [GOC:elh]
is_a: GO:0000731 ! DNA synthesis during DNA repair
relationship: part_of GO:0007534 ! gene conversion at mating-type locus

[Term]
id: GO:0000735
name: removal of nonhomologous ends
namespace: biological_process
def: "The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855]
is_a: GO:0000737 ! DNA catabolic process, endonucleolytic
relationship: part_of GO:0007534 ! gene conversion at mating-type locus

[Term]
id: GO:0000736
name: double-strand break repair via single-strand annealing, removal of nonhomologous ends
namespace: biological_process
def: "During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855]
subset: gosubset_prok
is_a: GO:0000737 ! DNA catabolic process, endonucleolytic
relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing

[Term]
id: GO:0000737
name: DNA catabolic process, endonucleolytic
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]
subset: gosubset_prok
synonym: "DNA breakdown, endonucleolytic" EXACT []
synonym: "DNA degradation, endonucleolytic" EXACT []
synonym: "endonucleolytic degradation of DNA" EXACT []
synonym: "endonucleolytic DNA catabolism" EXACT []
is_a: GO:0006308 ! DNA catabolic process

[Term]
id: GO:0000738
name: DNA catabolic process, exonucleolytic
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah]
subset: gosubset_prok
synonym: "DNA breakdown, exonucleolytic" EXACT []
synonym: "DNA degradation, exonucleolytic" EXACT []
synonym: "exonucleolytic degradation of DNA" EXACT []
is_a: GO:0006308 ! DNA catabolic process

[Term]
id: GO:0000739
name: DNA strand annealing activity
namespace: molecular_function
def: "Facilitates the base-pairing of complementary single-stranded DNA." [GOC:elh]
is_a: GO:0003690 ! double-stranded DNA binding
is_a: GO:0003697 ! single-stranded DNA binding

[Term]
id: GO:0000740
name: nuclear membrane fusion
namespace: biological_process
def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh]
is_a: GO:0090174 ! organelle membrane fusion

[Term]
id: GO:0000741
name: karyogamy
namespace: biological_process
alt_id: GO:0007335
def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh]
synonym: "nuclear fusion" EXACT []
synonym: "nuclear fusion during karyogamy" EXACT []
xref: Wikipedia:Karyogamy
is_a: GO:0048284 ! organelle fusion
relationship: part_of GO:0006997 ! nucleus organization

[Term]
id: GO:0000742
name: karyogamy during conjugation with cellular fusion
namespace: biological_process
def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy." [GOC:elh]
is_a: GO:0000741 ! karyogamy
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0000743
name: nuclear migration during conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0006946
def: "The net movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion." [GOC:clt]
synonym: "nuclear congression" BROAD []
is_a: GO:0030473 ! nuclear migration along microtubule
relationship: part_of GO:0000742 ! karyogamy during conjugation with cellular fusion

[Term]
id: GO:0000744
name: karyogamy during conjugation without cellular fusion
namespace: biological_process
def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after the mutual exchange of nuclei." [GOC:elh]
is_a: GO:0000741 ! karyogamy
relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange

[Term]
id: GO:0000745
name: nuclear migration during conjugation without cellular fusion
namespace: biological_process
def: "The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion." [GOC:clt, GOC:mah]
synonym: "nuclear exchange during conjugation without cellular fusion" RELATED []
is_a: GO:0007097 ! nuclear migration
relationship: part_of GO:0000744 ! karyogamy during conjugation without cellular fusion

[Term]
id: GO:0000746
name: conjugation
namespace: biological_process
def: "The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Conjugation
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0000747
name: conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007322
alt_id: GO:0007333
alt_id: GO:0030461
alt_id: GO:0030477
def: "A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh]
subset: goslim_pombe
synonym: "cell fusion" RELATED []
synonym: "mating" RELATED []
is_a: GO:0000746 ! conjugation
is_a: GO:0019953 ! sexual reproduction

[Term]
id: GO:0000748
name: conjugation with mutual genetic exchange
namespace: biological_process
def: "A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange." [GOC:elh]
synonym: "conjugation without cellular fusion" EXACT []
is_a: GO:0000746 ! conjugation

[Term]
id: GO:0000749
name: response to pheromone during conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007328
alt_id: GO:0030434
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus during the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt]
is_a: GO:0019236 ! response to pheromone
is_a: GO:0070887 ! cellular response to chemical stimulus
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0000750
name: pheromone-dependent signal transduction involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007330
alt_id: GO:0030454
def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt]
synonym: "transduction of mating signal" BROAD []
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway
is_a: GO:0032005 ! signal transduction involved in conjugation with cellular fusion
relationship: part_of GO:0000749 ! response to pheromone during conjugation with cellular fusion

[Term]
id: GO:0000751
name: cell cycle arrest in response to pheromone
namespace: biological_process
alt_id: GO:0030571
def: "The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt, GOC:dph, GOC:tb]
is_a: GO:0007050 ! cell cycle arrest
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0000749 ! response to pheromone during conjugation with cellular fusion

[Term]
id: GO:0000752
name: agglutination involved in conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007334
def: "During conjugation with cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions. An example of this process is agglutination in Saccharomyces cerevisiae." [GOC:elh]
synonym: "agglutination" BROAD []
synonym: "cell-cell adhesion during conjugation with cellular fusion" EXACT []
synonym: "cell-cell adhesion during mating" EXACT []
is_a: GO:0000771 ! agglutination involved in conjugation
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0000749 ! response to pheromone during conjugation with cellular fusion

[Term]
id: GO:0000753
name: cellular morphogenesis during conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007332
def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion." [GOC:clt]
synonym: "shmoo orientation" NARROW []
synonym: "shmooing" NARROW []
is_a: GO:0000767 ! cell morphogenesis during conjugation
relationship: part_of GO:0000749 ! response to pheromone during conjugation with cellular fusion

[Term]
id: GO:0000754
name: adaptation to pheromone during conjugation with cellular fusion
namespace: biological_process
alt_id: GO:0007331
alt_id: GO:0030453
def: "In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae." [GOC:clt]
synonym: "desensitization to pheromone during conjugation with cellular fusion" EXACT []
is_a: GO:0000749 ! response to pheromone during conjugation with cellular fusion
is_a: GO:0023058 ! adaptation of signaling pathway

[Term]
id: GO:0000755
name: cytogamy
namespace: biological_process
alt_id: GO:0000218
alt_id: GO:0030462
def: "During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh]
synonym: "zygote formation" NARROW []
is_a: GO:0022413 ! reproductive process in single-celled organism
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0000756
name: response to pheromone during conjugation without cellular fusion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus during the process of conjugation without cellular fusion." [GOC:clt]
is_a: GO:0007154 ! cell communication
is_a: GO:0019236 ! response to pheromone
is_a: GO:0070887 ! cellular response to chemical stimulus
relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange

[Term]
id: GO:0000757
name: signal transduction during conjugation without cellular fusion
namespace: biological_process
def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion." [GOC:clt]
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway
relationship: part_of GO:0000756 ! response to pheromone during conjugation without cellular fusion

[Term]
id: GO:0000758
name: agglutination involved in conjugation without cellular fusion
namespace: biological_process
def: "During conjugation without cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions." [GOC:elh]
is_a: GO:0000771 ! agglutination involved in conjugation
relationship: part_of GO:0000756 ! response to pheromone during conjugation without cellular fusion

[Term]
id: GO:0000759
name: cellular morphogenesis during conjugation without cellular fusion
namespace: biological_process
def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion." [GOC:clt]
is_a: GO:0000767 ! cell morphogenesis during conjugation
relationship: part_of GO:0000756 ! response to pheromone during conjugation without cellular fusion

[Term]
id: GO:0000760
name: adaptation to pheromone during conjugation without cellular fusion
namespace: biological_process
def: "In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses." [GOC:clt]
synonym: "desensitization to pheromone during conjugation without cellular fusion" EXACT []
is_a: GO:0000756 ! response to pheromone during conjugation without cellular fusion
is_a: GO:0022401 ! negative adaptation of signaling pathway

[Term]
id: GO:0000761
name: conjugant formation
namespace: biological_process
def: "During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing." [GOC:elh]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange

[Term]
id: GO:0000762
name: pheromone-induced unidirectional conjugation
namespace: biological_process
def: "The process of unidirectional (polarized) transfer of genetic information in response to a pheromone. It involves direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types." [GOC:elh]
is_a: GO:0009291 ! unidirectional conjugation

[Term]
id: GO:0000763
name: cellular morphogenesis during unidirectional conjugation
namespace: biological_process
def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation." [GOC:clt]
is_a: GO:0000767 ! cell morphogenesis during conjugation
relationship: part_of GO:0009291 ! unidirectional conjugation

[Term]
id: GO:0000764
name: cellular morphogenesis during pheromone-induced unidirectional conjugation
namespace: biological_process
def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation." [GOC:clt]
is_a: GO:0000763 ! cellular morphogenesis during unidirectional conjugation
relationship: part_of GO:0000765 ! response to pheromone during pheromone-induced unidirectional conjugation

[Term]
id: GO:0000765
name: response to pheromone during pheromone-induced unidirectional conjugation
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus during the process of pheromone-induced unidirectional conjugation." [GOC:clt]
is_a: GO:0019236 ! response to pheromone
relationship: part_of GO:0000762 ! pheromone-induced unidirectional conjugation

[Term]
id: GO:0000766
name: adaptation to pheromone during pheromone-induced unidirectional conjugation
namespace: biological_process
def: "In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses." [GOC:clt]
synonym: "desensitization to pheromone during pheromone-induced unidirectional conjugation" EXACT []
is_a: GO:0000765 ! response to pheromone during pheromone-induced unidirectional conjugation
is_a: GO:0022401 ! negative adaptation of signaling pathway

[Term]
id: GO:0000767
name: cell morphogenesis during conjugation
namespace: biological_process
def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types." [GOC:elh]
is_a: GO:0000902 ! cell morphogenesis

[Term]
id: GO:0000768
name: syncytium formation by plasma membrane fusion
namespace: biological_process
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb]
synonym: "cell fusion" BROAD []
synonym: "cell-cell fusion" EXACT []
is_a: GO:0006949 ! syncytium formation

[Term]
id: GO:0000769
name: syncytium formation by mitosis without cell division
namespace: biological_process
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cell division." [GOC:tb]
is_a: GO:0006949 ! syncytium formation

[Term]
id: GO:0000770
name: peptide pheromone export
namespace: biological_process
alt_id: GO:0007325
def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones." [GOC:elh]
synonym: "a-factor export" NARROW []
is_a: GO:0015833 ! peptide transport

[Term]
id: GO:0000771
name: agglutination involved in conjugation
namespace: biological_process
def: "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation." [GOC:elh]
is_a: GO:0007157 ! heterophilic cell adhesion
relationship: part_of GO:0000746 ! conjugation

[Term]
id: GO:0000772
name: mating pheromone activity
namespace: molecular_function
def: "The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted." [GOC:clt, GOC:elh]
is_a: GO:0005186 ! pheromone activity

[Term]
id: GO:0000773
name: phosphatidyl-N-methylethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine." [EC:2.1.1.71]
subset: gosubset_prok
synonym: "methyltransferase II" RELATED [EC:2.1.1.71]
synonym: "phosphatidyl-N-methylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71]
synonym: "phosphatidyl-N-monomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71]
synonym: "phosphatidylethanolamine methyltransferase I" RELATED [EC:2.1.1.71]
synonym: "phosphatidylmonomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71]
synonym: "phospholipid methyltransferase activity" EXACT [EC:2.1.1.71]
synonym: "PLMT" EXACT []
synonym: "S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.71]
xref: EC:2.1.1.71
xref: MetaCyc:2.1.1.71-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0000774
name: adenyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [GOC:kd]
subset: gosubset_prok
is_a: GO:0030554 ! adenyl nucleotide binding
is_a: GO:0060590 ! ATPase regulator activity

[Term]
id: GO:0000775
name: chromosome, centromeric region
namespace: cellular_component
def: "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]
comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
synonym: "centromere" RELATED []
synonym: "chromosome, centric region" EXACT []
synonym: "chromosome, pericentric region" RELATED []
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0000776
name: kinetochore
namespace: cellular_component
alt_id: GO:0005699
def: "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh]
subset: goslim_pir
xref: Wikipedia:Kinetochore
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000775 ! chromosome, centromeric region

[Term]
id: GO:0000777
name: condensed chromosome kinetochore
namespace: cellular_component
def: "A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules." [GOC:elh]
is_a: GO:0000776 ! kinetochore
relationship: part_of GO:0000779 ! condensed chromosome, centromeric region

[Term]
id: GO:0000778
name: condensed nuclear chromosome kinetochore
namespace: cellular_component
def: "A multisubunit complex that is located at the centromeric region of a condensed chromosome in the nucleus and provides an attachment point for the spindle microtubules." [GOC:elh]
is_a: GO:0000777 ! condensed chromosome kinetochore
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000780 ! condensed nuclear chromosome, centromeric region

[Term]
id: GO:0000779
name: condensed chromosome, centromeric region
namespace: cellular_component
def: "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]
comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
synonym: "condensed chromosome, centric region" EXACT []
synonym: "condensed chromosome, centromere" RELATED []
synonym: "condensed chromosome, pericentric region" RELATED []
is_a: GO:0000775 ! chromosome, centromeric region
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0000780
name: condensed nuclear chromosome, centromeric region
namespace: cellular_component
def: "The region of a condensed chromosome in the nucleus that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv]
comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
synonym: "condensed nuclear chromosome, centric region" EXACT []
synonym: "condensed nuclear chromosome, centromere" RELATED []
synonym: "condensed nuclear chromosome, pericentric region" RELATED []
is_a: GO:0000779 ! condensed chromosome, centromeric region
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0000781
name: chromosome, telomeric region
namespace: cellular_component
def: "The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
synonym: "telomere" RELATED []
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0000782
name: telomere cap complex
namespace: cellular_component
def: "A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome." [GOC:elh]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000781 ! chromosome, telomeric region

[Term]
id: GO:0000783
name: nuclear telomere cap complex
namespace: cellular_component
def: "A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome." [GOC:elh]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
is_a: GO:0000782 ! telomere cap complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region

[Term]
id: GO:0000784
name: nuclear chromosome, telomeric region
namespace: cellular_component
def: "The terminal region of a linear chromosome in the nucleus that includes the telomeric DNA repeats and associated proteins." [GOC:elh]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex.
synonym: "nuclear chromosome, telomere" EXACT []
is_a: GO:0000781 ! chromosome, telomeric region
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0000785
name: chromatin
namespace: cellular_component
alt_id: GO:0005717
def: "The ordered and organized complex of DNA and protein that forms the chromosome." [GOC:elh]
synonym: "chromosome scaffold" RELATED []
xref: NIF_Subcellular:sao1615953555
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0000786
name: nucleosome
namespace: cellular_component
alt_id: GO:0005718
def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh]
subset: goslim_pir
xref: Wikipedia:Nucleosome
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000785 ! chromatin

[Term]
id: GO:0000787
name: cytoplasmic nucleosome
namespace: cellular_component
def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures." [GOC:elh]
is_a: GO:0000786 ! nucleosome
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0000789 ! cytoplasmic chromatin

[Term]
id: GO:0000788
name: nuclear nucleosome
namespace: cellular_component
def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures." [GOC:elh]
is_a: GO:0000786 ! nucleosome
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0000789
name: cytoplasmic chromatin
namespace: cellular_component
def: "The ordered and organized complex of DNA and protein that forms the chromosome in the cytoplasm." [GOC:elh]
is_a: GO:0000785 ! chromatin
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0000229 ! cytoplasmic chromosome

[Term]
id: GO:0000790
name: nuclear chromatin
namespace: cellular_component
def: "The ordered and organized complex of DNA and protein that forms the chromosome in the nucleus." [GOC:elh]
is_a: GO:0000785 ! chromatin
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0000791
name: euchromatin
namespace: cellular_component
def: "A dispersed and relatively uncompacted form of chromatin." [GOC:elh]
xref: NIF_Subcellular:sao445485807
xref: Wikipedia:Euchromatin
is_a: GO:0000785 ! chromatin

[Term]
id: GO:0000792
name: heterochromatin
namespace: cellular_component
def: "A compact and highly condensed form of chromatin." [GOC:elh]
xref: NIF_Subcellular:sao581845896
xref: Wikipedia:Heterochromatin
is_a: GO:0000785 ! chromatin

[Term]
id: GO:0000793
name: condensed chromosome
namespace: cellular_component
def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh]
comment: Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis.
synonym: "cytoplasmic mitotic chromosome" RELATED []
synonym: "metaphase chromosome" RELATED []
synonym: "mitotic chromosome" RELATED []
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0000794
name: condensed nuclear chromosome
namespace: cellular_component
def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus." [GOC:elh]
comment: Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome.
synonym: "meiotic chromosome" RELATED []
synonym: "nuclear mitotic chromosome" RELATED []
is_a: GO:0000228 ! nuclear chromosome
is_a: GO:0000793 ! condensed chromosome

[Term]
id: GO:0000795
name: synaptonemal complex
namespace: cellular_component
alt_id: GO:0005716
def: "A proteinaceous scaffold found between homologous chromosomes during meiosis." [GOC:elh]
xref: Wikipedia:Synaptonemal_complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0000796
name: condensin complex
namespace: cellular_component
alt_id: GO:0005676
alt_id: GO:0008620
def: "A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh]
subset: goslim_pir
synonym: "13S condensin complex" NARROW []
synonym: "SMC complex" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0000797
name: condensin core heterodimer
namespace: cellular_component
alt_id: GO:0008621
def: "The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh]
synonym: "8S condensin complex" NARROW []
synonym: "Smc2-Smc4 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000796 ! condensin complex

[Term]
id: GO:0000798
name: nuclear cohesin complex
namespace: cellular_component
def: "A cohesin complex required for cohesion between sister chromatids that remain in the nucleus." [GOC:elh]
comment: Note that this term and its children should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i.e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used.
is_a: GO:0008278 ! cohesin complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0000799
name: nuclear condensin complex
namespace: cellular_component
def: "A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus." [GOC:elh]
is_a: GO:0000796 ! condensin complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0000800
name: lateral element
namespace: cellular_component
def: "A proteinaceous core found between sister chromatids during meiotic prophase." [GOC:elh]
synonym: "axial element" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000795 ! synaptonemal complex

[Term]
id: GO:0000801
name: central element
namespace: cellular_component
def: "A structural unit of the synaptonemal complex found between the lateral elements." [GOC:elh]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000795 ! synaptonemal complex

[Term]
id: GO:0000802
name: transverse filament
namespace: cellular_component
def: "A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them." [GOC:elh]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000795 ! synaptonemal complex

[Term]
id: GO:0000803
name: sex chromosome
namespace: cellular_component
def: "A chromosome involved in sex determination." [GOC:elh]
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0000804
name: W chromosome
namespace: cellular_component
def: "The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females." [GOC:mah, ISBN:0321000382]
xref: Wikipedia:ZW_sex-determination_system
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000805
name: X chromosome
namespace: cellular_component
def: "The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, ISBN:0582227089]
xref: Wikipedia:X_chromosome
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000806
name: Y chromosome
namespace: cellular_component
def: "The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males." [GOC:mah, ISBN:0582227089]
xref: Wikipedia:Y_chromosome
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000807
name: Z chromosome
namespace: cellular_component
def: "The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females." [GOC:mah, ISBN:0321000382]
xref: Wikipedia:ZW_sex-determination_system
is_a: GO:0000803 ! sex chromosome

[Term]
id: GO:0000808
name: origin recognition complex
namespace: cellular_component
def: "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh]
subset: goslim_pir
subset: gosubset_prok
synonym: "ORC" EXACT []
synonym: "origin of replication recognition complex" EXACT []
xref: Wikipedia:Origin_recognition_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0000809
name: cytoplasmic origin of replication recognition complex
namespace: cellular_component
def: "A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm." [GOC:elh]
subset: gosubset_prok
synonym: "cytoplasmic ORC" EXACT []
synonym: "prokaryotic ORC" RELATED []
is_a: GO:0000808 ! origin recognition complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0000229 ! cytoplasmic chromosome

[Term]
id: GO:0000810
name: diacylglycerol pyrophosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: diacylglycerol pyrophosphate + H20 = 3-sn-phosphatidate + phosphate." [EC:3.6.1.-, PMID:8567632, PMID:9452443]
synonym: "DGPP phosphatase activity" EXACT []
synonym: "DGPP phosphohydrolase activity" EXACT []
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0000811
name: GINS complex
namespace: cellular_component
def: "A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990]
synonym: "Go, Ichi, Ni and San complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0000812
name: Swr1 complex
namespace: cellular_component
def: "A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits." [PMID:14645854, PMID:14690608]
synonym: "SWR-C" EXACT []
is_a: GO:0016585 ! chromatin remodeling complex
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0000813
name: ESCRT I complex
namespace: cellular_component
def: "An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
synonym: "Endosomal Sorting Complex Required for Transport" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0000814
name: ESCRT II complex
namespace: cellular_component
def: "An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
synonym: "Endosomal Sorting Complex Required for Transport" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0000815
name: ESCRT III complex
namespace: cellular_component
def: "An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes." [GOC:rb, PMID:12892785, PMID:12900393]
synonym: "Endosomal Sorting Complex Required for Transport" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0000816
name: nicotinamide riboside kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nicotinamide riboside = ADP + nicotinamide nucleotide (NMN)." [PMID:15137942]
is_a: GO:0019206 ! nucleoside kinase activity

[Term]
id: GO:0000817
name: COMA complex
namespace: cellular_component
def: "A multiprotein complex in yeast consisting of Ctf19p, Okp1p, Mcm21p, and Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly." [GOC:se, PMID:14633972]
synonym: "Ctf19p-Okp1p-Mcm1p-Ame1p complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore

[Term]
id: GO:0000818
name: nuclear MIS12/MIND type complex
namespace: cellular_component
def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1." [GOC:krc, GOC:se, PMID:14633972]
synonym: "MIND complex" EXACT []
synonym: "Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex" EXACT []
is_a: GO:0000444 ! MIS12/MIND type complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore

[Term]
id: GO:0000819
name: sister chromatid segregation
namespace: biological_process
def: "The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051276 ! chromosome organization
relationship: part_of GO:0007059 ! chromosome segregation

[Term]
id: GO:0000820
name: regulation of glutamine family amino acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:go_curators]
synonym: "regulation of glutamine family amino acid metabolism" EXACT []
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
relationship: regulates GO:0009064 ! glutamine family amino acid metabolic process

[Term]
id: GO:0000821
name: regulation of arginine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ChEBI:29016, GOC:go_curators]
synonym: "regulation of arginine metabolism" EXACT []
is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process
relationship: regulates GO:0006525 ! arginine metabolic process

[Term]
id: GO:0000822
name: inositol hexakisphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with inositol hexakisphosphate." [GOC:go_curators]
synonym: "InsP6 binding" EXACT []
synonym: "IP6 binding" EXACT []
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0000823
name: inositol trisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate." [GOC:elh]
synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" EXACT []
synonym: "EC:2.7.1.151" BROAD []
synonym: "inositol polyphosphate multikinase activity" BROAD []
synonym: "IpmK" BROAD []
is_a: GO:0051766 ! inositol trisphosphate kinase activity

[Term]
id: GO:0000824
name: inositol tetrakisphosphate 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [GOC:elh]
synonym: "1D-myo-inositol-tetrakisphosphate 3-kinase activity" EXACT []
synonym: "EC:2.7.1.151" BROAD []
synonym: "inositol 1,4,5,6-tetrakisphosphate 3-kinase activity" EXACT []
synonym: "inositol polyphosphate multikinase activity" BROAD []
synonym: "IpmK" BROAD []
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0000825
name: inositol tetrakisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [GOC:elh]
synonym: "1D-myo-inositol-tetrakisphosphate 6-kinase activity" EXACT []
synonym: "inositol 1,3,4,5-tetrakisphosphate 6-kinase activity" EXACT []
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0000826
name: inositol pyrophosphate synthase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of inositol phosphates which possess pyrophosphate bonds." [GOC:elh, PMID:16429326]
synonym: "inositol diphosphate synthase activity" EXACT []
is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0000827
name: inositol 1,3,4,5,6-pentakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)." [GOC:elh, PMID:11311242]
synonym: "EC:2.7.4.21" BROAD []
is_a: GO:0000826 ! inositol pyrophosphate synthase activity

[Term]
id: GO:0000828
name: inositol hexakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate (IP6) = ADP + diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5; isomer unknown)." [GOC:elh, PMID:16429326]
xref: MetaCyc:2.7.1.152-RXN
is_a: GO:0000826 ! inositol pyrophosphate synthase activity

[Term]
id: GO:0000829
name: inositol heptakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5; isomer unknown) = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4; isomer unknown)." [GOC:elh, PMID:16429326]
is_a: GO:0000826 ! inositol pyrophosphate synthase activity

[Term]
id: GO:0000830
name: inositol hexakisphosphate 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate." [GOC:elh, PMID:16429326]
is_a: GO:0033187 ! inositol hexakisphosphate 4-kinase or 6-kinase activity

[Term]
id: GO:0000831
name: inositol hexakisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [GOC:elh, PMID:16429326]
is_a: GO:0033187 ! inositol hexakisphosphate 4-kinase or 6-kinase activity

[Term]
id: GO:0000832
name: inositol hexakisphosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate." [GOC:elh, PMID:16429326]
synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT []
synonym: "EC:2.7.4.21" BROAD []
is_a: GO:0000828 ! inositol hexakisphosphate kinase activity

[Term]
id: GO:0000833
name: inositol heptakisphosphate 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate." [GOC:elh, PMID:16429326]
synonym: "diphosphoinositol-pentakisphosphate 4-kinase activity" EXACT []
synonym: "IP7 4-kinase activity" EXACT []
is_a: GO:0033199 ! inositol heptakisphosphate 4-kinase or 6-kinase activity

[Term]
id: GO:0000834
name: inositol heptakisphosphate 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [GOC:elh, PMID:16429326]
is_a: GO:0033199 ! inositol heptakisphosphate 4-kinase or 6-kinase activity

[Term]
id: GO:0000835
name: ER ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex found in the ER." [GOC:elh]
is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0000836
name: Hrd1p ubiquitin ligase complex
namespace: cellular_component
def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066]
is_a: GO:0000835 ! ER ubiquitin ligase complex

[Term]
id: GO:0000837
name: Doa10p ubiquitin ligase complex
namespace: cellular_component
def: "A multiprotein complex that recognizes and ubiquitinates membranes proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p." [GOC:elh, PMID:16873066]
synonym: "Ssm4p ubiquitin ligase complex" EXACT []
is_a: GO:0000835 ! ER ubiquitin ligase complex

[Term]
id: GO:0000838
name: Hrd1p ubiquitin ligase ERAD-M complex
namespace: cellular_component
def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066]
is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex

[Term]
id: GO:0000839
name: Hrd1p ubiquitin ligase ERAD-L complex
namespace: cellular_component
def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873065, PMID:16873066]
is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex

[Term]
id: GO:0000900
name: translation repressor activity, nucleic acid binding
namespace: molecular_function
def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid." [GOC:clt]
is_a: GO:0030371 ! translation repressor activity
is_a: GO:0090079 ! translation regulator activity, nucleic acid binding

[Term]
id: GO:0000901
name: translation repressor activity, non-nucleic acid binding
namespace: molecular_function
def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid." [GOC:clt]
is_a: GO:0030371 ! translation repressor activity
is_a: GO:0045183 ! translation factor activity, non-nucleic acid binding

[Term]
id: GO:0000902
name: cell morphogenesis
namespace: biological_process
alt_id: GO:0007148
alt_id: GO:0045790
alt_id: GO:0045791
def: "The developmental process by which the size or shape of a cell is generated and organized. Morphogenesis pertains to the creation of form." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb]
subset: gosubset_prok
synonym: "cellular morphogenesis" EXACT []
is_a: GO:0032989 ! cellular component morphogenesis

[Term]
id: GO:0000903
name: cell morphogenesis during vegetative growth
namespace: biological_process
def: "The change in cell shape that occurs during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods." [GOC:clt, GOC:go_curators]
synonym: "cellular morphogenesis during vegetative growth" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000902 ! cell morphogenesis

[Term]
id: GO:0000904
name: cell morphogenesis involved in differentiation
namespace: biological_process
def: "The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:go_curators]
is_a: GO:0000902 ! cell morphogenesis
relationship: part_of GO:0048468 ! cell development

[Term]
id: GO:0000905
name: sporocarp development involved in asexual reproduction
namespace: biological_process
def: "The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction." [GOC:clt, GOC:mtg_sensu]
synonym: "conidium development" NARROW []
synonym: "fruiting body formation involved in asexual reproduction" BROAD []
synonym: "haploid fruiting" RELATED []
synonym: "homokaryotic fruiting" RELATED []
synonym: "imperfect stage fruiting body development" NARROW []
synonym: "monokaryotic fruiting" RELATED []
is_a: GO:0030584 ! sporocarp development
relationship: part_of GO:0019954 ! asexual reproduction

[Term]
id: GO:0000906
name: 6,7-dimethyl-8-ribityllumazine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate." [EC:5.4.-.-, PMID:7559556]
synonym: "lumazine synthase activity" BROAD [MetaCyc:LUMAZINESYN-CPLX]
xref: EC:5.4.-.-
is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups

[Term]
id: GO:0000907
name: sulfonate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = SO3(2-) (sulfite) + aminoacetaldehyde + succinate + CO2." [EC:1.14.11.-, GOC:clt, PMID:10482536]
subset: gosubset_prok
synonym: "sulfonate/alpha-ketoglutarate dioxygenase activity" EXACT []
synonym: "sulphonate dioxygenase activity" EXACT []
xref: EC:1.14.11.-
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0000908
name: taurine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: taurine + 2-oxoglutarate + O2 = SO3(2-) (sulfite) + aminoacetaldehyde + succinate + CO2." [EC:1.14.11.17, MetaCyc:RXN0-299]
subset: gosubset_prok
synonym: "2-aminoethanesulfonate dioxygenase activity" EXACT [EC:1.14.11.17]
synonym: "alpha-ketoglutarate-dependent taurine dioxygenase activity" EXACT [EC:1.14.11.17]
synonym: "taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)" EXACT [EC:1.14.11.17]
xref: EC:1.14.11.17
xref: MetaCyc:RXN0-299
is_a: GO:0000907 ! sulfonate dioxygenase activity

[Term]
id: GO:0000909
name: sporocarp development involved in sexual reproduction
namespace: biological_process
def: "The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi." [GOC:clt, GOC:mtg_sensu]
synonym: "ascus development" NARROW []
synonym: "fruiting body development involved in sexual reproduction" BROAD []
synonym: "fruiting body formation involved in sexual reproduction" BROAD []
synonym: "perfect stage fruiting body development" NARROW []
is_a: GO:0030584 ! sporocarp development
relationship: part_of GO:0019953 ! sexual reproduction

[Term]
id: GO:0000910
name: cytokinesis
namespace: biological_process
alt_id: GO:0007104
alt_id: GO:0016288
def: "A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components." [GOC:ai]
subset: goslim_candida
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:449273 "Mitotic Telophase /Cytokinesis"
xref: Reactome:470393 "Mitotic Telophase /Cytokinesis"
xref: Reactome:488068 "Mitotic Telophase /Cytokinesis"
xref: Reactome:508035 "Mitotic Telophase /Cytokinesis"
xref: Reactome:517891 "Mitotic Telophase /Cytokinesis"
xref: Reactome:526715 "Mitotic Telophase /Cytokinesis"
xref: Reactome:531490 "Mitotic Telophase /Cytokinesis"
xref: Reactome:542630 "Mitotic Telophase /Cytokinesis"
xref: Reactome:547945 "Mitotic Telophase /Cytokinesis"
xref: Reactome:552520 "Mitotic Telophase /Cytokinesis"
xref: Reactome:558142 "Mitotic Telophase /Cytokinesis"
xref: Reactome:586024 "Mitotic Telophase /Cytokinesis"
xref: Reactome:592880 "Mitotic Telophase /Cytokinesis"
xref: Reactome:68884 "Mitotic Telophase /Cytokinesis"
xref: Wikipedia:Cytokinesis
is_a: GO:0051301 ! cell division

[Term]
id: GO:0000911
name: cytokinesis by cell plate formation
namespace: biological_process
def: "The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana." [GOC:clt]
is_a: GO:0033205 ! cytokinesis during cell cycle

[Term]
id: GO:0000912
name: assembly of actomyosin apparatus involved in cytokinesis
namespace: biological_process
def: "The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:mah]
synonym: "actomyosin apparatus assembly involved in cytokinesis" EXACT [GOC:mah]
synonym: "cytokinesis, formation of actomyosin apparatus" EXACT [GOC:dph, GOC:tb]
synonym: "formation of actomyosin apparatus involved in cytokinesis" RELATED [GOC:dph]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0031032 ! actomyosin structure organization
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0033205 ! cytokinesis during cell cycle

[Term]
id: GO:0000913
name: preprophase band assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation." [GOC:clt, GOC:mah]
synonym: "preprophase band formation" RELATED [GOC:mah]
is_a: GO:0007105 ! cytokinesis, site selection
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0000911 ! cytokinesis by cell plate formation

[Term]
id: GO:0000914
name: phragmoplast assembly
namespace: biological_process
def: "The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles)." [GOC:clt]
synonym: "phragmoplast formation" RELATED [goc:dph]
is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cytokinesis
relationship: part_of GO:0000911 ! cytokinesis by cell plate formation

[Term]
id: GO:0000915
name: cytokinesis, actomyosin contractile ring assembly
namespace: biological_process
alt_id: GO:0045573
def: "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb]
synonym: "constriction ring assembly" NARROW []
synonym: "contractile ring assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cytokinesis, actomyosin contractile ring formation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cytokinesis, actomyosin ring biosynthesis" RELATED []
synonym: "cytokinesis, actomyosin ring formation" RELATED []
synonym: "cytokinesis, contractile ring assembly" RELATED [GOC:mah]
is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cytokinesis

[Term]
id: GO:0000916
name: contractile ring contraction involved in cytokinesis during cell cycle
namespace: biological_process
def: "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb]
synonym: "contractile ring constriction" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cytokinesis, actomyosin ring contraction" EXACT []
synonym: "cytokinesis, contractile ring contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0033205 ! cytokinesis during cell cycle

[Term]
id: GO:0000917
name: barrier septum formation
namespace: biological_process
def: "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a barrier septum are not able to exchange intracellular material." [GOC:clt, GOC:mah]
synonym: "barrier septum assembly" EXACT [GOC:mah]
synonym: "formation of barrier septum" EXACT []
synonym: "septation" BROAD []
synonym: "septin assembly and septum biosynthesis" RELATED []
synonym: "septin assembly and septum formation" RELATED []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0032506 ! cytokinetic process

[Term]
id: GO:0000918
name: selection of site for barrier septum formation
namespace: biological_process
def: "The process of marking the site where a barrier septum will form." [GOC:clt]
synonym: "selection of site for barrier cell septum biosynthesis" EXACT []
synonym: "selection of site for barrier cell septum formation" EXACT []
synonym: "septin assembly and septum biosynthesis" BROAD []
synonym: "septin assembly and septum formation" BROAD []
synonym: "septum positioning" EXACT []
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0000917 ! barrier septum formation

[Term]
id: GO:0000919
name: cell plate assembly
namespace: biological_process
def: "The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast." [GOC:clt]
synonym: "cell plate formation" RELATED [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0000911 ! cytokinesis by cell plate formation

[Term]
id: GO:0000920
name: cell separation during cytokinesis
namespace: biological_process
def: "The process of physically separating progeny cells during cytokinesis; this may involve enzymatic digestion of septum or cell wall components." [GOC:clt]
synonym: "rotokinesis" NARROW []
is_a: GO:0032506 ! cytokinetic process

[Term]
id: GO:0000921
name: septin ring assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex." [GOC:clt]
subset: gosubset_prok
synonym: "septin assembly and septum biosynthesis" BROAD []
synonym: "septin assembly and septum formation" BROAD []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0031106 ! septin ring organization

[Term]
id: GO:0000922
name: spindle pole
namespace: cellular_component
alt_id: GO:0030615
def: "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0000923
name: equatorial microtubule organizing center
namespace: cellular_component
def: "A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis." [PMID:11792817]
synonym: "EMTOC" EXACT []
synonym: "equatorial microtubule organising centre" EXACT []
is_a: GO:0005815 ! microtubule organizing center
is_a: GO:0032155 ! cell division site part

[Term]
id: GO:0000924
name: gamma-tubulin ring complex, centrosomal
namespace: cellular_component
alt_id: GO:0000925
alt_id: GO:0000926
def: "A centrosome-localized multiprotein complex composed of gamma-tubulin and other non-tubulin proteins assembled into a ring structure that is thought to be the unit of nucleation at the minus end of a microtubule. Gamma-tubulin small complexes are thought to be the core repeating units of the ring." [GOC:clt, GOC:mtg_sensu, PMID:12134075, PMID:17021256]
synonym: "gamma-tubulin large complex, centrosomal" EXACT []
is_a: GO:0008274 ! gamma-tubulin ring complex
relationship: part_of GO:0000242 ! pericentriolar material

[Term]
id: GO:0000927
name: gamma-tubulin small complex, centrosomal
namespace: cellular_component
def: "A centrosomal complex usually comprising two gamma-tubulin molecules, at least two conserved non-tubulin proteins that multimerize along with additional non-tubulin proteins in animal cells into larger functional complexes. Gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. An example of this structure is found in Mus musculus." [GOC:mtg_sensu, PMID:12134075]
is_a: GO:0008275 ! gamma-tubulin small complex

[Term]
id: GO:0000928
name: gamma-tubulin small complex, spindle pole body
namespace: cellular_component
def: "A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae." [GOC:mtg_sensu, PMID:12134075]
synonym: "Tub4 complex" EXACT []
is_a: GO:0008275 ! gamma-tubulin small complex
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0000930
name: gamma-tubulin complex
namespace: cellular_component
def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044450 ! microtubule organizing center part

[Term]
id: GO:0000931
name: gamma-tubulin large complex
namespace: cellular_component
alt_id: GO:0000929
def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe." [GOC:mtg_sensu, PMID:12134075]
is_a: GO:0000930 ! gamma-tubulin complex

[Term]
id: GO:0000932
name: cytoplasmic mRNA processing body
namespace: cellular_component
def: "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603]
synonym: "cytoplasmic foci" RELATED []
synonym: "P body" EXACT []
synonym: "P-body" EXACT []
xref: Wikipedia:P_body
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0000933
name: adventitious septum
namespace: cellular_component
def: "A cell septum whose formation is independent of nuclear division." [GOC:clt, ISBN:0471940526]
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000934
name: porous cell septum
namespace: cellular_component
def: "A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments." [GOC:clt]
synonym: "porous septum" BROAD []
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000935
name: barrier septum
namespace: cellular_component
def: "A septum which spans a cell and does not allow exchange of organelles or cytoplasm between compartments." [GOC:clt]
synonym: "complete septum" EXACT []
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000936
name: primary cell septum
namespace: cellular_component
def: "A cell septum that forms following nuclear division." [GOC:clt, ISBN:0471940526]
synonym: "primary septum" BROAD []
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0000937
name: dolipore septum
namespace: cellular_component
def: "A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome)." [GOC:clt]
is_a: GO:0000934 ! porous cell septum

[Term]
id: GO:0000938
name: GARP complex
namespace: cellular_component
def: "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664]
synonym: "Golgi associated retrograde protein complex" EXACT []
synonym: "VFT tethering complex" EXACT []
synonym: "Vps fifty three tethering complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0000939
name: inner kinetochore of condensed chromosome
namespace: cellular_component
def: "The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:11483983]
synonym: "inner centromere core complex" RELATED []
synonym: "inner kinetochore plate" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000777 ! condensed chromosome kinetochore

[Term]
id: GO:0000940
name: outer kinetochore of condensed chromosome
namespace: cellular_component
def: "The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983]
synonym: "outer kinetochore plate" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000777 ! condensed chromosome kinetochore

[Term]
id: GO:0000941
name: inner kinetochore of condensed nuclear chromosome
namespace: cellular_component
def: "The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:1148398]
is_a: GO:0000939 ! inner kinetochore of condensed chromosome
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore

[Term]
id: GO:0000942
name: outer kinetochore of condensed nuclear chromosome
namespace: cellular_component
def: "The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:1148398]
is_a: GO:0000940 ! outer kinetochore of condensed chromosome
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore

[Term]
id: GO:0000943
name: retrotransposon nucleocapsid
namespace: cellular_component
def: "A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog." [GOC:clt, PMID:10861903]
synonym: "Virus-like particle" EXACT []
synonym: "VLP" EXACT []
xref: Wikipedia:Virus-like_particle
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0000944
name: base pairing with rRNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with ribosomal ribonucleic acid (rRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target rRNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000498 ! base pairing with RNA
is_a: GO:0019843 ! rRNA binding

[Term]
id: GO:0000945
name: base pairing with snRNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with small nuclear ribonucleic acid (snRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target snRNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000498 ! base pairing with RNA
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0000946
name: base pairing with tRNA
namespace: molecular_function
def: "Interacting selectively and non-covalently with transfer ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target tRNA molecule." [GOC:krc]
comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function.
is_a: GO:0000049 ! tRNA binding
is_a: GO:0000498 ! base pairing with RNA

[Term]
id: GO:0000947
name: amino acid catabolic process to alcohol via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0000948
name: amino acid catabolic process to carboxylic acid via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432]
is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0000949
name: aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway
is_a: GO:0009074 ! aromatic amino acid family catabolic process

[Term]
id: GO:0000950
name: branched chain family amino acid catabolic process to alcohol via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway
is_a: GO:0009083 ! branched chain family amino acid catabolic process

[Term]
id: GO:0000951
name: methionine catabolic process to 3-methylthiopropanol
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway
is_a: GO:0009087 ! methionine catabolic process

[Term]
id: GO:0000952
name: aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432]
is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway
is_a: GO:0009074 ! aromatic amino acid family catabolic process

[Term]
id: GO:0000953
name: branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432]
is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway
is_a: GO:0009083 ! branched chain family amino acid catabolic process

[Term]
id: GO:0000954
name: methionine catabolic process to 3-methylthiopropanoate
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432]
is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway
is_a: GO:0009087 ! methionine catabolic process

[Term]
id: GO:0000955
name: amino acid catabolic process via Ehrlich pathway
namespace: biological_process
def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols." [GOC:krc, PMID:18281432]
is_a: GO:0009063 ! cellular amino acid catabolic process

[Term]
id: GO:0000956
name: nuclear-transcribed mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc]
synonym: "nuclear mRNA breakdown" EXACT []
synonym: "nuclear mRNA catabolism" EXACT []
synonym: "nuclear mRNA degradation" EXACT []
is_a: GO:0006402 ! mRNA catabolic process

[Term]
id: GO:0000957
name: mitochondrial RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006401 ! RNA catabolic process

[Term]
id: GO:0000958
name: mitochondrial mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0000957 ! mitochondrial RNA catabolic process
is_a: GO:0006402 ! mRNA catabolic process

[Term]
id: GO:0000959
name: mitochondrial RNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0000960
name: regulation of mitochondrial RNA catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: regulates GO:0000957 ! mitochondrial RNA catabolic process

[Term]
id: GO:0000961
name: negative regulation of mitochondrial RNA catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah]
is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0051253 ! negative regulation of RNA metabolic process
relationship: negatively_regulates GO:0000957 ! mitochondrial RNA catabolic process

[Term]
id: GO:0000962
name: positive regulation of mitochondrial RNA catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah]
is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0051254 ! positive regulation of RNA metabolic process
relationship: positively_regulates GO:0000957 ! mitochondrial RNA catabolic process

[Term]
id: GO:0000963
name: mitochondrial RNA processing
namespace: biological_process
def: "The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion." [GOC:krc, GOC:mah]
is_a: GO:0000959 ! mitochondrial RNA metabolic process
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0000964
name: mitochondrial RNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah]
synonym: "mitochondrial RNA 5' end processing" RELATED []
is_a: GO:0000963 ! mitochondrial RNA processing
is_a: GO:0000966 ! RNA 5'-end processing

[Term]
id: GO:0000965
name: mitochondrial RNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah]
synonym: "mitochondrial RNA 3' end processing" RELATED []
is_a: GO:0000963 ! mitochondrial RNA processing
is_a: GO:0031123 ! RNA 3'-end processing

[Term]
id: GO:0000966
name: RNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of an RNA molecule." [GOC:krc]
synonym: "RNA 5' end processing" EXACT []
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0000967
name: rRNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of an rRNA molecule." [GOC:krc]
synonym: "rRNA 5' end processing" EXACT []
is_a: GO:0034471 ! ncRNA 5'-end processing

[Term]
id: GO:0000968
name: tRNA exon ligation
namespace: biological_process
def: "The process by which the two exons of a pre-tRNA which has had the intron removed are rejoined." [GOC:krc]
is_a: GO:0000378 ! RNA exon ligation
relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation

[Term]
id: GO:0000969
name: tRNA exon ligation utilizing ATP as source of linkage phosphate
namespace: biological_process
def: "The process by which the two exons of a pre-tRNA which has had the intron removed are rejoined where the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in vertebrate species." [GOC:krc, PMID:17786051]
is_a: GO:0000968 ! tRNA exon ligation

[Term]
id: GO:0000970
name: tRNA exon ligation utilizing GTP as source of linkage phosphate
namespace: biological_process
def: "The process by which the two exons of a pre-tRNA which has had the intron removed are rejoined where the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2'-phosphate at the splice junction which is subsequently removed as part of the ligation process." [GOC:krc, PMID:18217203, PMID:9299409]
is_a: GO:0000968 ! tRNA exon ligation

[Term]
id: GO:0000971
name: tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate
namespace: biological_process
def: "The process by which the two exons of a pre-tRNA which has had the intron removed are rejoined where the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans." [GOC:krc, PMID:17786051, PMID:18217203, PMID:9299409]
is_a: GO:0000968 ! tRNA exon ligation

[Term]
id: GO:0000972
name: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
namespace: biological_process
def: "The process by which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript." [GOC:krc, PMID:18614049]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0000973
name: posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
namespace: biological_process
def: "The process by which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed." [GOC:krc, PMID:17373856, PMID:18614049]
is_a: GO:0000972 ! transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

[Term]
id: GO:0000974
name: Prp19 complex
namespace: cellular_component
def: "A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." [GOC:krc, PMID:16540691, PMID:19239890]
synonym: "nineteen complex" NARROW []
synonym: "NTC" RELATED []
synonym: "Prp19/CDC5 complex" NARROW []
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0001100
name: negative regulation of exit from mitosis
namespace: biological_process
def: "Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:rn]
synonym: "down regulation of exit from mitosis" EXACT []
synonym: "down-regulation of exit from mitosis" EXACT []
synonym: "downregulation of exit from mitosis" EXACT []
synonym: "inhibition of exit from mitosis" NARROW []
is_a: GO:0007096 ! regulation of exit from mitosis
is_a: GO:0010948 ! negative regulation of cell cycle process
relationship: negatively_regulates GO:0010458 ! exit from mitosis

[Term]
id: GO:0001101
name: response to acid
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acid stimulus." [GOC:rn]
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0001300
name: chronological cell aging
namespace: biological_process
def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state." [GOC:jh, PMID:12044934]
synonym: "chronological cell ageing" EXACT []
is_a: GO:0007569 ! cell aging

[Term]
id: GO:0001301
name: progressive alteration of chromatin during cell aging
namespace: biological_process
def: "The process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype." [GOC:jh, PMID:12044938]
synonym: "age-dependent accumulation of genetic damage" RELATED []
synonym: "progressive alteration of chromatin during cell ageing" EXACT []
is_a: GO:0016568 ! chromatin modification
relationship: part_of GO:0007569 ! cell aging

[Term]
id: GO:0001302
name: replicative cell aging
namespace: biological_process
def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division." [GOC:jh, PMID:12044934]
synonym: "replicative cell ageing" EXACT []
is_a: GO:0007569 ! cell aging

[Term]
id: GO:0001303
name: nucleolar fragmentation during replicative aging
namespace: biological_process
def: "Process of enlargement and fragmentation of the nucleolus into multiple rounded structures that occurs in conjunction with increasing age in dividing cells." [GOC:jh, PMID:9891807]
synonym: "nucleolar fragmentation during replicative ageing" EXACT []
is_a: GO:0007576 ! nucleolar fragmentation
relationship: part_of GO:0001302 ! replicative cell aging

[Term]
id: GO:0001304
name: progressive alteration of chromatin during replicative cell aging
namespace: biological_process
def: "The process that occurs in dividing cells as they age that results in changes to chromatin structure." [GOC:jh]
synonym: "progressive alteration of chromatin during replicative cell ageing" EXACT []
is_a: GO:0001301 ! progressive alteration of chromatin during cell aging
relationship: part_of GO:0001302 ! replicative cell aging

[Term]
id: GO:0001305
name: progressive alteration of chromatin during chronological cell aging
namespace: biological_process
def: "The process that occurs in non-dividing cells as they age that results in changes to chromatin structure." [GOC:jh]
synonym: "progressive alteration of chromatin during chronological cell ageing" EXACT []
is_a: GO:0001301 ! progressive alteration of chromatin during cell aging
relationship: part_of GO:0001300 ! chronological cell aging

[Term]
id: GO:0001306
name: age-dependent response to oxidative stress
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938]
is_a: GO:0006979 ! response to oxidative stress
is_a: GO:0007571 ! age-dependent general metabolic decline

[Term]
id: GO:0001307
name: extrachromosomal circular DNA accumulation during replicative cell aging
namespace: biological_process
def: "Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh]
synonym: "extrachromosomal circular DNA accumulation during replicative cell ageing" EXACT []
is_a: GO:0001304 ! progressive alteration of chromatin during replicative cell aging
is_a: GO:0007580 ! extrachromosomal circular DNA accumulation during cell aging

[Term]
id: GO:0001308
name: loss of chromatin silencing during replicative cell aging
namespace: biological_process
def: "The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins." [GOC:jh, PMID:12044934]
synonym: "loss of chromatin silencing during replicative cell ageing" EXACT []
is_a: GO:0001304 ! progressive alteration of chromatin during replicative cell aging
is_a: GO:0006345 ! loss of chromatin silencing

[Term]
id: GO:0001309
name: age-dependent telomere shortening
namespace: biological_process
def: "Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process." [GOC:jh, PMID:9891807]
is_a: GO:0001304 ! progressive alteration of chromatin during replicative cell aging
is_a: GO:0010834 ! telomere maintenance via telomere shortening

[Term]
id: GO:0001310
name: extrachromosomal rDNA circle accumulation during replicative cell aging
namespace: biological_process
def: "Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh, PMID:12044934]
synonym: "extrachromosomal rDNA circle accumulation during replicative cell ageing" EXACT []
synonym: "extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" EXACT []
is_a: GO:0001307 ! extrachromosomal circular DNA accumulation during replicative cell aging

[Term]
id: GO:0001311
name: formation of extrachromosomal circular rDNA by homologous recombination during replicative cell aging
namespace: biological_process
def: "Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age." [GOC:jh, PMID:12044934]
synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell ageing" EXACT []
synonym: "formation of extrachromosomal circular ribosomal DNA by homologous recombination during replicative cell aging" EXACT []
is_a: GO:0001313 ! formation of extrachromosomal circular DNA during replicative cell aging
relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation during replicative cell aging

[Term]
id: GO:0001312
name: replication of extrachromosomal rDNA circles during replicative cell aging
namespace: biological_process
def: "Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication." [GOC:jh, PMID:12044934]
synonym: "replication of extrachromosomal rDNA circles during replicative cell ageing" EXACT []
synonym: "replication of extrachromosomal ribosomal DNA circles during replicative cell aging" EXACT []
is_a: GO:0001314 ! replication of extrachromosomal circular DNA during replicative cell aging
relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation during replicative cell aging

[Term]
id: GO:0001313
name: formation of extrachromosomal circular DNA during replicative cell aging
namespace: biological_process
def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age." [GOC:jh]
synonym: "formation of extrachromosomal circular DNA during replicative cell ageing" EXACT []
is_a: GO:0001325 ! formation of extrachromosomal circular DNA
relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation during replicative cell aging

[Term]
id: GO:0001314
name: replication of extrachromosomal circular DNA during replicative cell aging
namespace: biological_process
def: "Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh]
synonym: "replication of extrachromosomal circular DNA during replicative cell ageing" EXACT []
is_a: GO:0001326 ! replication of extrachromosomal circular DNA
relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation during replicative cell aging

[Term]
id: GO:0001315
name: age-dependent response to reactive oxygen species
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938]
subset: gosubset_prok
synonym: "age-dependent response to active oxygen species" EXACT []
synonym: "age-dependent response to AOS" EXACT []
synonym: "age-dependent response to reactive oxidative species" EXACT []
synonym: "age-dependent response to reactive oxygen intermediate" EXACT []
synonym: "age-dependent response to ROI" EXACT []
synonym: "age-dependent response to ROS" EXACT []
is_a: GO:0000302 ! response to reactive oxygen species

[Term]
id: GO:0001316
name: age-dependent response to reactive oxygen species during replicative cell aging
namespace: biological_process
def: "A change in state or activity of a cell or an organism occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh]
synonym: "age-dependent response to active oxygen species during replicative cell aging" EXACT []
synonym: "age-dependent response to AOS during replicative cell aging" EXACT []
synonym: "age-dependent response to reactive oxidative species during replicative cell aging" EXACT []
synonym: "age-dependent response to reactive oxygen intermediate during replicative cell aging" EXACT []
synonym: "age-dependent response to reactive oxygen species during replicative cell ageing" EXACT []
synonym: "age-dependent response to ROI during replicative cell aging" EXACT []
synonym: "age-dependent response to ROS during replicative cell aging" EXACT []
is_a: GO:0001315 ! age-dependent response to reactive oxygen species
is_a: GO:0001322 ! age-dependent response to oxidative stress during replicative cell aging

[Term]
id: GO:0001317
name: accumulation of oxidatively modified proteins during replicative cell aging
namespace: biological_process
def: "Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh]
synonym: "accumulation of oxidatively modified proteins during replicative cell ageing" EXACT []
is_a: GO:0001316 ! age-dependent response to reactive oxygen species during replicative cell aging

[Term]
id: GO:0001318
name: formation of oxidatively modified proteins during replicative cell aging
namespace: biological_process
def: "Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh]
synonym: "formation of oxidatively modified proteins during replicative cell ageing" EXACT []
is_a: GO:0043687 ! post-translational protein modification
relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins during replicative cell aging

[Term]
id: GO:0001319
name: inheritance of oxidatively modified proteins during replicative cell aging
namespace: biological_process
def: "Process by which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells." [GOC:jh]
synonym: "inheritance of oxidatively modified proteins during replicative cell ageing" EXACT []
is_a: GO:0008105 ! asymmetric protein localization
relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins during replicative cell aging

[Term]
id: GO:0001320
name: age-dependent response to reactive oxygen species during chronological cell aging
namespace: biological_process
def: "A change in state or activity of a cell or an organism occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh]
synonym: "age-dependent response to active oxygen species during chronological cell aging" EXACT []
synonym: "age-dependent response to AOS during chronological cell aging" EXACT []
synonym: "age-dependent response to reactive oxidative species during chronological cell aging" EXACT []
synonym: "age-dependent response to reactive oxygen intermediate during chronological cell aging" EXACT []
synonym: "age-dependent response to reactive oxygen species during chronological cell ageing" EXACT []
synonym: "age-dependent response to ROI during chronological cell aging" EXACT []
synonym: "age-dependent response to ROS during chronological cell aging" EXACT []
is_a: GO:0001315 ! age-dependent response to reactive oxygen species
is_a: GO:0001324 ! age-dependent response to oxidative stress during chronological cell aging

[Term]
id: GO:0001321
name: age-dependent general metabolic decline during replicative cell aging
namespace: biological_process
def: "The process, arising in dividing cells as they age, that alters cellular metabolism and thus causes a decline in cell function." [GOC:jh]
synonym: "age-dependent general metabolic decline during replicative cell ageing" EXACT []
is_a: GO:0007571 ! age-dependent general metabolic decline
relationship: part_of GO:0001302 ! replicative cell aging

[Term]
id: GO:0001322
name: age-dependent response to oxidative stress during replicative cell aging
namespace: biological_process
def: "A change in state or activity of a cell or an organism occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh]
synonym: "age-dependent response to oxidative stress during replicative cell ageing" EXACT []
is_a: GO:0001306 ! age-dependent response to oxidative stress
is_a: GO:0001321 ! age-dependent general metabolic decline during replicative cell aging

[Term]
id: GO:0001323
name: age-dependent general metabolic decline during chronological cell aging
namespace: biological_process
def: "The process, arising in non-dividing cells as they age, that alters cellular metabolism and thus causes a decline in cell function." [GOC:jh]
synonym: "age-dependent general metabolic decline during chronological cell ageing" EXACT []
is_a: GO:0007571 ! age-dependent general metabolic decline
relationship: part_of GO:0001300 ! chronological cell aging

[Term]
id: GO:0001324
name: age-dependent response to oxidative stress during chronological cell aging
namespace: biological_process
def: "A change in state or activity of a cell or an organism occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh]
synonym: "age-dependent response to oxidative stress during chronological cell ageing" EXACT []
is_a: GO:0001306 ! age-dependent response to oxidative stress
is_a: GO:0001323 ! age-dependent general metabolic decline during chronological cell aging

[Term]
id: GO:0001325
name: formation of extrachromosomal circular DNA
namespace: biological_process
def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats." [GOC:jh, PMID:12044938]
subset: gosubset_prok
is_a: GO:0000737 ! DNA catabolic process, endonucleolytic
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0001326
name: replication of extrachromosomal circular DNA
namespace: biological_process
def: "Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh]
subset: gosubset_prok
is_a: GO:0006260 ! DNA replication

[Term]
id: GO:0001400
name: mating projection base
namespace: cellular_component
def: "The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone." [GOC:mcc]
synonym: "base of shmoo tip" NARROW []
synonym: "conjugation tube base" NARROW []
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0005937 ! mating projection

[Term]
id: GO:0001401
name: mitochondrial sorting and assembly machinery complex
namespace: cellular_component
def: "A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex." [PMID:12891361]
comment: See also the cellular component term 'mitochondrial outer membrane translocase complex ; GO:0005742'.
synonym: "SAM complex" EXACT []
synonym: "TOB complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005741 ! mitochondrial outer membrane

[Term]
id: GO:0001402
name: signal transduction during filamentous growth
namespace: biological_process
def: "Relaying of environmental signals promoting filamentous growth." [GOC:mcc, PMID:9728395]
synonym: "MAPKKK cascade (pseudohyphal growth)" RELATED []
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0030447 ! filamentous growth

[Term]
id: GO:0001403
name: invasive growth in response to glucose limitation
namespace: biological_process
def: "A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:9728395]
comment: Note that this term should not be used to describe the invasion of host tissues by pathogenic organisms, which is described by the biological process term 'invasive growth', nor should it be used to describe growth of diseased cells of an organism into the surrounding normal tissue, which is outside of the scope of GO.
synonym: "colony morphology" RELATED []
is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells

[Term]
id: GO:0001404
name: invasive growth
namespace: biological_process
def: "OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue." [GOC:mcc, PMID:9728395]
comment: This term was made obsolete because more appropriate terms were created.
synonym: "tissue invasion" EXACT []
is_obsolete: true
consider: GO:0044409

[Term]
id: GO:0001405
name: presequence translocase-associated import motor
namespace: cellular_component
def: "Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the presequence translocase complex; hydrolyzes ATP to provide the force to drive import of proteins into the mitochondrial matrix." [GOC:mcc, PMID:14517234, PMID:14638855]
synonym: "mitochondrial import motor" EXACT []
synonym: "PAM complex" EXACT []
synonym: "pre-sequence translocase-associated import motor" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005744 ! mitochondrial inner membrane presequence translocase complex

[Term]
id: GO:0001406
name: glycerophosphodiester transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892]
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity

[Term]
id: GO:0001407
name: glycerophosphodiester transport
namespace: biological_process
def: "The directed movement of glycerophosphodiesters into, out of, within or between cells by means of some external agent such as a transporter or pore. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892]
is_a: GO:0015748 ! organophosphate ester transport

[Term]
id: GO:0001408
name: guanine nucleotide transport
namespace: biological_process
def: "The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mcc]
is_a: GO:0015860 ! purine nucleoside transport
is_a: GO:0015865 ! purine nucleotide transport

[Term]
id: GO:0001409
name: guanine nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of the membrane to the other." [GOC:mcc]
is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity

[Term]
id: GO:0001410
name: chlamydospore formation
namespace: biological_process
alt_id: GO:0055027
def: "The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans." [GOC:mcc, GOC:mtg_sensu, ISBN:085199377X, PMID:14663094]
synonym: "chlamydospore development" EXACT []
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore
is_a: GO:0048468 ! cell development

[Term]
id: GO:0001411
name: hyphal tip
namespace: cellular_component
def: "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation." [GOC:mcc]
subset: goslim_candida
is_a: GO:0030427 ! site of polarized growth

[Term]
id: GO:0001501
name: skeletal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jic, GOC:tb, http://www.stedmans.com/]
synonym: "skeletal development" EXACT []
is_a: GO:0048731 ! system development

[Term]
id: GO:0001502
name: cartilage condensation
namespace: biological_process
def: "The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes." [ISBN:0878932437]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0048705 ! skeletal system morphogenesis
relationship: part_of GO:0051216 ! cartilage development

[Term]
id: GO:0001503
name: ossification
namespace: biological_process
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, http://cancerweb.ncl.ac.uk/]
synonym: "bone biosynthesis" EXACT []
synonym: "bone formation" EXACT []
synonym: "osteogenesis" EXACT []
xref: Wikipedia:Ossification
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0060348 ! bone development

[Term]
id: GO:0001504
name: neurotransmitter uptake
namespace: biological_process
def: "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. It does not occur during cholinergic synaptic transmission. Instead, acetylcholine is enzymatically degraded in the synaptic cleft." [ISBN:0123668387]
synonym: "neurotransmitter import" EXACT [GOC:dph, GOC:tb]
synonym: "neurotransmitter import into glial cell" NARROW []
synonym: "neurotransmitter import into neuron" NARROW []
synonym: "neurotransmitter recycling" BROAD []
synonym: "neurotransmitter reuptake" EXACT []
xref: Reactome:112313 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:449130 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:470241 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:487924 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:507895 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:517787 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:526617 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:531417 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:536788 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:542545 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:547873 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:552446 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:558058 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:568703 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:581906 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:585943 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:599756 "Neurotransmitter uptake and Metabolism In Glial Cells"
xref: Reactome:602566 "Neurotransmitter uptake and Metabolism In Glial Cells"
is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0006836 ! neurotransmitter transport

[Term]
id: GO:0001505
name: regulation of neurotransmitter levels
namespace: biological_process
def: "Any process that modulates levels of neurotransmitter." [GOC:jl]
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0007268 ! synaptic transmission

[Term]
id: GO:0001506
name: neurotransmitter biosynthetic process and storage
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules." [GOC:go_curators, ISBN:0123668387]
comment: This term was made obsolete because it is an amalgamation of its two children.
synonym: "neurotransmitter anabolism and storage" EXACT []
synonym: "neurotransmitter formation and storage" EXACT []
synonym: "neurotransmitter synthesis and storage" EXACT []
is_obsolete: true
consider: GO:0042136
consider: GO:0042137

[Term]
id: GO:0001507
name: acetylcholine catabolic process in synaptic cleft
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission." [GOC:ai]
synonym: "acetylcholine breakdown in synaptic cleft" EXACT []
synonym: "acetylcholine degradation in synaptic cleft" EXACT []
is_a: GO:0006581 ! acetylcholine catabolic process
relationship: part_of GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0001508
name: regulation of action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0001509
name: legumain activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds." [EC:3.4.22.34]
comment: This term was made obsolete because it represents a gene product.
synonym: "asparaginyl endopeptidase activity" RELATED [EC:3.4.22.34]
synonym: "bean endopeptidase activity" RELATED [EC:3.4.22.34]
synonym: "citvac" RELATED [EC:3.4.22.34]
synonym: "hemoglobinase activity" RELATED [EC:3.4.22.34]
synonym: "phaseolin activity" RELATED [EC:3.4.22.34]
synonym: "proteinase B" RELATED [EC:3.4.22.34]
synonym: "PRSC1 gene product (Homo sapiens)" RELATED [EC:3.4.22.34]
synonym: "vicilin peptidohydrolase activity" RELATED [EC:3.4.22.34]
xref: EC:3.4.22.34
xref: MetaCyc:3.4.22.34-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0001510
name: RNA methylation
namespace: biological_process
def: "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd]
subset: gosubset_prok
is_a: GO:0009451 ! RNA modification
is_a: GO:0043414 ! macromolecule methylation

[Term]
id: GO:0001511
name: fibrillin
namespace: molecular_function
def: "OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0001527
consider: GO:0005509

[Term]
id: GO:0001512
name: dihydronicotinamide riboside quinone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone." [EC:1.10.99.2]
synonym: "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase activity" EXACT [EC:1.10.99.2]
synonym: "N-ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [EC:1.10.99.2]
synonym: "NAD(P)H:quinone oxidoreductase 2 activity" EXACT [EC:1.10.99.2]
synonym: "NAD(P)H:quinone oxidoreductase-2" RELATED [EC:1.10.99.2]
synonym: "NAD(P)H:quinone oxidoreductase2" RELATED [EC:1.10.99.2]
synonym: "NQO(2) activity" EXACT [EC:1.10.99.2]
synonym: "NQO2" RELATED [EC:1.10.99.2]
synonym: "NRH:quinone oxidoreductase 2 activity" NARROW [EC:1.10.99.2]
synonym: "QR2 activity" RELATED [EC:1.10.99.2]
synonym: "quinone reductase 2 activity" RELATED [EC:1.10.99.2]
synonym: "ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT []
xref: EC:1.10.99.2
xref: MetaCyc:1.10.99.2-RXN
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0001514
name: selenocysteine incorporation
namespace: biological_process
def: "The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine." [RESID:AA0022]
subset: gosubset_prok
xref: RESID:AA0022
is_a: GO:0006451 ! translational readthrough

[Term]
id: GO:0001515
name: opioid peptide activity
namespace: molecular_function
def: "Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0001516
name: prostaglandin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring." [GOC:ai]
subset: gosubset_prok
synonym: "prostaglandin anabolism" EXACT []
synonym: "prostaglandin biosynthesis" EXACT []
synonym: "prostaglandin formation" EXACT []
synonym: "prostaglandin synthesis" EXACT []
is_a: GO:0006693 ! prostaglandin metabolic process
is_a: GO:0046457 ! prostanoid biosynthetic process

[Term]
id: GO:0001517
name: N-acetylglucosamine 6-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate." [GOC:ai, GOC:hjd]
synonym: "N-acetylglucosamine 6-O-sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0001518
name: voltage-gated sodium channel complex
namespace: cellular_component
def: "A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "voltage gated sodium channel complex" EXACT []
synonym: "voltage-dependent sodium channel complex" EXACT []
synonym: "voltage-sensitive sodium channel complex" EXACT []
xref: NIF_Subcellular:sao785001660
is_a: GO:0034706 ! sodium channel complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0001519
name: peptide amidation
namespace: biological_process
def: "The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions." [PMID:11028916]
subset: gosubset_prok
is_a: GO:0031179 ! peptide modification

[Term]
id: GO:0001520
name: outer dense fiber
namespace: cellular_component
def: "Structure or material found in the flagella of mammalian sperm that surrounds each of the nine microtubule doublets, giving a 9 + 9 + 2 arrangement rather than the 9 + 2 pattern usually seen. These dense fibers are stiff and noncontractile." [ISBN:0824072820]
synonym: "outer dense fibre" EXACT []
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0001522
name: pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah]
subset: gosubset_prok
synonym: "pseudouridylation" EXACT []
xref: Wikipedia:Pseudouridine
xref: Wikipedia:Pseudouridylation
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0001523
name: retinoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "retinoid metabolism" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process

[Term]
id: GO:0001524
name: globin
namespace: molecular_function
def: "OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0005344

[Term]
id: GO:0001525
name: angiogenesis
namespace: biological_process
def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453]
synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym []
xref: Wikipedia:Angiogenesis
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048514 ! blood vessel morphogenesis

[Term]
id: GO:0001526
name: proteoglycan sulfate transfer
namespace: biological_process
def: "OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3'-phosphoadenyl sulfate." [GOC:hjd]
comment: This term was made obsolete because it represents a group of molecular functions.
synonym: "proteoglycan sulphate transfer" EXACT []
is_obsolete: true
consider: GO:0006029
consider: GO:0006790
consider: GO:0050698

[Term]
id: GO:0001527
name: microfibril
namespace: cellular_component
def: "Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins." [http://www.xrefer.com/entry/490235]
synonym: "extended fibrils" EXACT []
synonym: "fibrillin" RELATED []
is_a: GO:0043205 ! fibril

[Term]
id: GO:0001528
name: elastin
namespace: molecular_function
def: "OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0030023

[Term]
id: GO:0001529
name: elastin
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0030023

[Term]
id: GO:0001530
name: lipopolysaccharide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lipopolysaccharide." [PMID:11079463]
synonym: "endotoxin binding" BROAD []
synonym: "LPS binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0001531
name: interleukin-21 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-21 receptor." [GOC:ai]
synonym: "IL-21" NARROW []
synonym: "interleukin-21 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0001532
name: interleukin-21 receptor activity
namespace: molecular_function
def: "Combining with interleukin-21 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-21 receptor activity" EXACT [GOC:mah]
synonym: "IL-21R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0019977 ! interleukin-21 binding

[Term]
id: GO:0001533
name: cornified envelope
namespace: cellular_component
def: "An insoluble protein structure formed under the plasma membrane of cornifying epithelial cells." [PMID:11112355]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0001534
name: radial spoke
namespace: cellular_component
def: "Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules." [ISBN:0124325653, PMID:9450971]
subset: goslim_pir
xref: Wikipedia:Radial_spoke
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0001535
name: radial spokehead
namespace: cellular_component
def: "Protein complex forming part of eukaryotic flagellar apparatus." [GOC:hjd]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part
relationship: part_of GO:0001534 ! radial spoke

[Term]
id: GO:0001536
name: radial spoke stalk
namespace: cellular_component
def: "Globular portion of the radial spoke that projects towards the central pair of microtubules." [GOC:hjd]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part
relationship: part_of GO:0001534 ! radial spoke

[Term]
id: GO:0001537
name: N-acetylgalactosamine 4-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate." [EC:2.8.2.-, GOC:ai]
synonym: "N-acetylgalactosamine 4-O-sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0001539
name: ciliary or flagellar motility
namespace: biological_process
def: "Cell motility due to movement of cilia or flagella." [GOC:hjd]
subset: gosubset_prok
synonym: "ciliary/flagellar motility" EXACT []
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0001540
name: beta-amyloid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor." [GOC:hjd]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001541
name: ovarian follicle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [GOC:go_curators]
synonym: "follicular phase" RELATED []
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0001542
name: ovulation from ovarian follicle
namespace: biological_process
def: "The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus." [GOC:mtg_sensu, http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0030728 ! ovulation
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0001543
name: ovarian follicle rupture
namespace: biological_process
def: "Disruption of theca cell layer releasing follicular fluid and/or the oocyte." [http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001542 ! ovulation from ovarian follicle

[Term]
id: GO:0001544
name: initiation of primordial ovarian follicle growth
namespace: biological_process
def: "Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle)." [http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0001545
name: primary ovarian follicle growth
namespace: biological_process
def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle)." [GOC:mtg_mpo, http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0022605 ! oogenesis stage
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0001546
name: preantral ovarian follicle growth
namespace: biological_process
def: "Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation." [http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0022605 ! oogenesis stage
relationship: part_of GO:0001541 ! ovarian follicle development
relationship: part_of GO:0048162 ! multi-layer follicle stage, oogenesis

[Term]
id: GO:0001547
name: antral ovarian follicle growth
namespace: biological_process
def: "Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity." [http://ovary.stanford.edu]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0001548
name: follicular fluid formation in ovarian follicle antrum
namespace: biological_process
def: "The menstrual cycle process by which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed during the various stages of oogenesis." [GOC:dph, GOC:tb, http://ovary.stanford.edu]
synonym: "ovarian follicle antrum/follicular fluid biosynthesis" EXACT []
synonym: "ovarian follicle antrum/follicular fluid formation" EXACT []
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0022605 ! oogenesis stage
relationship: part_of GO:0001547 ! antral ovarian follicle growth

[Term]
id: GO:0001549
name: cumulus cell differentiation
namespace: biological_process
def: "The process whereby a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell." [http://ovary.stanford.edu]
synonym: "ovarian cumulus cell differentiation" EXACT []
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0030154 ! cell differentiation
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0001547 ! antral ovarian follicle growth
relationship: part_of GO:0048165 ! fused antrum stage, oogenesis

[Term]
id: GO:0001550
name: ovarian cumulus expansion
namespace: biological_process
def: "Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells." [http://ovary.stanford.edu]
synonym: "ovarian cumulus growth" RELATED []
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0022605 ! oogenesis stage
relationship: part_of GO:0001547 ! antral ovarian follicle growth
relationship: part_of GO:0048165 ! fused antrum stage, oogenesis

[Term]
id: GO:0001551
name: ovarian follicle endowment
namespace: biological_process
def: "Association of oocytes with supporting epithelial granulosa cells to form primordial follicles." [http://ovary.stanford.edu]
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0001552
name: ovarian follicle atresia
namespace: biological_process
def: "Ovarian follicle demise mediated by apoptosis." [http://ovary.stanford.edu]
is_a: GO:0006915 ! apoptosis
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0001553
name: luteinization
namespace: biological_process
def: "The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation." [http://ovary.stanford.edu]
synonym: "luteal phase" RELATED []
xref: Wikipedia:Luteal_phase
xref: Wikipedia:Luteinization
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0001554
name: luteolysis
namespace: biological_process
def: "Regression of ovarian corpora lutea." [http://ovary.stanford.edu]
xref: Wikipedia:Luteolysis
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0008585 ! female gonad development

[Term]
id: GO:0001555
name: oocyte growth
namespace: biological_process
def: "The process by which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [http://ovary.stanford.edu]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048588 ! developmental cell growth
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0048601 ! oocyte morphogenesis

[Term]
id: GO:0001556
name: oocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, http://ovary.stanford.edu]
xref: Wikipedia:Oocyte_maturation
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048469 ! cell maturation
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0048599 ! oocyte development

[Term]
id: GO:0001557
name: metabolic process resulting in cell growth
namespace: biological_process
def: "OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell." [GOC:dph]
comment: This term was made obsolete as part of the metabolism rearrangements, because it is redundant with other terms.
is_obsolete: true
replaced_by: GO:0008152
replaced_by: GO:0016049

[Term]
id: GO:0001558
name: regulation of cell growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell growth." [GOC:go_curators]
subset: gosubset_prok
xref: Reactome:110498 "DTOR is positively regulated by DRheb-GTP"
is_a: GO:0040008 ! regulation of growth
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0016049 ! cell growth

[Term]
id: GO:0001559
name: regulation of cell growth by detection of nuclear:cytoplasmic ratio
namespace: biological_process
def: "Any process whereby the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph]
synonym: "detection of nuclear:cytoplasmic ratio to regulate cell growth" EXACT []
synonym: "interpretation of nuclear:cytoplasmic ratio to regulate cell growth" EXACT []
synonym: "regulation of cell growth by nuclear:cytoplasmic ratio" EXACT []
synonym: "regulation of cell growth by sensing of nuclear:cytoplasmic ratio" EXACT []
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0016475 ! detection of nuclear:cytoplasmic ratio

[Term]
id: GO:0001560
name: regulation of cell growth by extracellular stimulus
namespace: biological_process
def: "Any process whereby external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph]
synonym: "interpretation of external signals that regulate cell growth" EXACT []
synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT []
synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT []
synonym: "regulation of growth by exogenous signal" EXACT []
synonym: "regulation of growth by exogenous stimuli" EXACT []
synonym: "regulation of growth by exogenous stimulus" EXACT []
synonym: "regulation of growth by external signal" EXACT []
synonym: "regulation of growth by external stimuli" EXACT []
synonym: "regulation of growth by external stimulus" EXACT []
is_a: GO:0001558 ! regulation of cell growth
relationship: part_of GO:0031668 ! cellular response to extracellular stimulus

[Term]
id: GO:0001561
name: fatty acid alpha-oxidation
namespace: biological_process
def: "A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway." [http://www.peroxisome.org/Scientist/Biochemistry/alpha-oxidation.html]
subset: gosubset_prok
xref: MetaCyc:PWY-2501
xref: Reactome:389599 "Alpha-oxidation of phytanate"
xref: Reactome:448559 "Alpha-oxidation of phytanate"
xref: Reactome:469688 "Alpha-oxidation of phytanate"
xref: Reactome:487400 "Alpha-oxidation of phytanate"
xref: Reactome:507352 "Alpha-oxidation of phytanate"
xref: Reactome:517362 "Alpha-oxidation of phytanate"
xref: Reactome:526240 "Alpha-oxidation of phytanate"
xref: Reactome:531117 "Alpha-oxidation of phytanate"
xref: Reactome:536493 "Alpha-oxidation of phytanate"
xref: Reactome:542198 "Alpha-oxidation of phytanate"
xref: Reactome:547556 "Alpha-oxidation of phytanate"
xref: Reactome:552155 "Alpha-oxidation of phytanate"
xref: Reactome:557743 "Alpha-oxidation of phytanate"
xref: Reactome:568360 "Alpha-oxidation of phytanate"
xref: Reactome:581562 "Alpha-oxidation of phytanate"
xref: Reactome:592458 "Alpha-oxidation of phytanate"
xref: Reactome:595541 "Alpha-oxidation of phytanate"
xref: Reactome:597289 "Alpha-oxidation of phytanate"
xref: Reactome:598097 "Alpha-oxidation of phytanate"
xref: Reactome:599642 "Alpha-oxidation of phytanate"
xref: Reactome:600577 "Alpha-oxidation of phytanate"
xref: Reactome:602442 "Alpha-oxidation of phytanate"
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0001562
name: response to protozoan
namespace: biological_process
alt_id: GO:0042833
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan." [GOC:ai]
synonym: "resistance to pathogenic protozoa" RELATED []
synonym: "response to protozoa" EXACT []
synonym: "response to protozoon" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0001563
name: detection of protozoan
namespace: biological_process
def: "The series of events in which a stimulus from a protozoan is received and converted into a molecular signal." [GOC:ai]
synonym: "detection of protozoa" EXACT []
synonym: "detection of protozoon" EXACT []
synonym: "perception of protozoa" RELATED []
is_a: GO:0001562 ! response to protozoan
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0001564
name: resistance to pathogenic protozoa
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0001562

[Term]
id: GO:0001565
name: phorbol ester receptor activity
namespace: molecular_function
def: "Combining with a phorbol ester to initiate a change in cell activity." [GOC:ai, PMID:10506570]
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0001566
name: non-kinase phorbol ester receptor activity
namespace: molecular_function
def: "Phorbol ester/diacylglycerol binding proteins that do not have intrinsic kinase activity." [PMID:10506570]
is_a: GO:0001565 ! phorbol ester receptor activity

[Term]
id: GO:0001567
name: cholesterol 25-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O." [EC:1.14.99.38]
synonym: "cholesterol 25-monooxygenase activity" EXACT [EC:1.14.99.38]
synonym: "cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity" EXACT [EC:1.14.99.38]
xref: EC:1.14.99.38
xref: MetaCyc:1.14.99.38-RXN
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0001568
name: blood vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001944 ! vasculature development

[Term]
id: GO:0001569
name: patterning of blood vessels
namespace: biological_process
def: "The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph]
synonym: "branching involved in blood vessel morphogenesis" EXACT [GOC:dph]
is_a: GO:0007389 ! pattern specification process
is_a: GO:0048754 ! branching morphogenesis of a tube
relationship: part_of GO:0001525 ! angiogenesis

[Term]
id: GO:0001570
name: vasculogenesis
namespace: biological_process
def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798]
synonym: "vascular morphogenesis" EXACT []
xref: Wikipedia:Vasculogenesis
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048514 ! blood vessel morphogenesis

[Term]
id: GO:0001571
name: non-tyrosine kinase fibroblast growth factor receptor activity
namespace: molecular_function
def: "A receptor belonging to the FGFR family but lacking the tyrosine kinase domain." [PMID:11418238]
synonym: "non-tyrosine kinase FGF receptor activity" EXACT []
synonym: "non-tyrosine kinase FGFR activity" EXACT []
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0001572
name: lactosylceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal beta(1,4)Glc beta(1,1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0471586501]
subset: gosubset_prok
synonym: "lactosylceramide anabolism" EXACT []
synonym: "lactosylceramide biosynthesis" EXACT []
synonym: "lactosylceramide formation" EXACT []
synonym: "lactosylceramide synthesis" EXACT []
is_a: GO:0006688 ! glycosphingolipid biosynthetic process
is_a: GO:0046476 ! glycosylceramide biosynthetic process
is_a: GO:0046478 ! lactosylceramide metabolic process

[Term]
id: GO:0001573
name: ganglioside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ganglioside metabolism" EXACT []
is_a: GO:0006672 ! ceramide metabolic process
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0001574
name: ganglioside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ganglioside anabolism" EXACT []
synonym: "ganglioside biosynthesis" EXACT []
synonym: "ganglioside formation" EXACT []
synonym: "ganglioside synthesis" EXACT []
is_a: GO:0001573 ! ganglioside metabolic process
is_a: GO:0006688 ! glycosphingolipid biosynthetic process

[Term]
id: GO:0001575
name: globoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1,3)-Gal-alpha(1,4)Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "globoside metabolism" EXACT []
is_a: GO:0006672 ! ceramide metabolic process
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0001576
name: globoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1,3)-Gal-alpha(1,4)Glc(I)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "globoside anabolism" EXACT []
synonym: "globoside biosynthesis" EXACT []
synonym: "globoside formation" EXACT []
synonym: "globoside synthesis" EXACT []
is_a: GO:0001575 ! globoside metabolic process
is_a: GO:0006688 ! glycosphingolipid biosynthetic process

[Term]
id: GO:0001577
name: galectin
namespace: molecular_function
def: "OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars." [PMID:9786891]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "S-type lectin" EXACT []
is_obsolete: true
consider: GO:0007157
consider: GO:0016936

[Term]
id: GO:0001578
name: microtubule bundle formation
namespace: biological_process
def: "A process that results in a parallel arrangement of microtubules." [GOC:dph]
synonym: "microtubule bundling" EXACT []
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0001579
name: medium-chain fatty acid transport
namespace: biological_process
def: "The directed movement of medium-chain fatty acids into, out of, within or between cells by means of some external agent such as a transporter or pore. Medium-chain fatty acids are fatty acids with a chain length of between 8 and 12 carbons." [GOC:ai]
is_a: GO:0015908 ! fatty acid transport

[Term]
id: GO:0001580
name: detection of chemical stimulus involved in sensory perception of bitter taste
namespace: biological_process
def: "The series of events required for a bitter taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
synonym: "bitter taste detection" EXACT []
synonym: "perception of bitter taste, detection of chemical stimulus" EXACT []
synonym: "perception of bitter taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of bitter taste" EXACT []
synonym: "sensory detection of chemical stimulus during perception of bitter taste" EXACT []
synonym: "sensory transduction of bitter taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of bitter taste" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
relationship: part_of GO:0050913 ! sensory perception of bitter taste

[Term]
id: GO:0001581
name: detection of chemical stimulus involved in sensory perception of sour taste
namespace: biological_process
def: "The series of events required for a sour taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
synonym: "perception of sour taste, detection of chemical stimulus" EXACT []
synonym: "perception of sour taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of sour taste" EXACT []
synonym: "sensory detection of sour taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of sour taste" EXACT []
synonym: "sensory transduction of sour taste" EXACT []
synonym: "sour taste detection" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
relationship: part_of GO:0050915 ! sensory perception of sour taste

[Term]
id: GO:0001582
name: detection of chemical stimulus involved in sensory perception of sweet taste
namespace: biological_process
def: "The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
synonym: "perception of sweet taste, detection of chemical stimulus" EXACT []
synonym: "perception of sweet taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of sweet taste" EXACT []
synonym: "sensory detection of sweet taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of sweet taste" EXACT []
synonym: "sensory transduction of sweet taste" EXACT []
synonym: "sweet taste detection" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
relationship: part_of GO:0050916 ! sensory perception of sweet taste

[Term]
id: GO:0001583
name: detection of chemical stimulus involved in sensory perception of salty taste
namespace: biological_process
def: "The series of events required for a salty taste stimulus to be received and converted to a molecular signal." [GOC:go_curators]
synonym: "perception of salty taste, detection of chemical stimulus" EXACT []
synonym: "perception of salty taste, sensory transduction of chemical stimulus" EXACT []
synonym: "salty taste detection" EXACT []
synonym: "sensory detection of chemical stimulus during perception of salty taste" EXACT []
synonym: "sensory detection of salty taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of salty taste" EXACT []
synonym: "sensory transduction of salty taste" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
relationship: part_of GO:0050914 ! sensory perception of salty taste

[Term]
id: GO:0001584
name: rhodopsin-like receptor activity
namespace: molecular_function
alt_id: GO:0001620
def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the rhodopsin receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1505]
comment: This term was made obsolete because it represents a gene product and is named based on protein features.
subset: gosubset_prok
synonym: "Class A G protein coupled receptor" EXACT []
synonym: "Class A G-protein coupled receptor" EXACT []
synonym: "Class A GPCR" EXACT []
synonym: "class A orphan receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001586
name: 5-HT1 receptor activity
namespace: molecular_function
is_a: GO:0004993 ! serotonin receptor activity

[Term]
id: GO:0001587
name: 5-HT2 receptor activity
namespace: molecular_function
is_a: GO:0004993 ! serotonin receptor activity

[Term]
id: GO:0001588
name: dopamine receptor activity, coupled via Gs
namespace: molecular_function
def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity." [GOC:mah, ISBN:0953351033]
is_a: GO:0004952 ! dopamine receptor activity

[Term]
id: GO:0001589
name: dopamine D5 receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D5 receptors." [IUPHAR_RECEPTOR:2260]
is_a: GO:0001588 ! dopamine receptor activity, coupled via Gs

[Term]
id: GO:0001590
name: dopamine D1 receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D1 receptors." [IUPHAR_RECEPTOR:2252]
is_a: GO:0001588 ! dopamine receptor activity, coupled via Gs

[Term]
id: GO:0001591
name: dopamine receptor activity, coupled via Gi/Go
namespace: molecular_function
def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity." [GOC:mah, ISBN:0953351033]
is_a: GO:0004952 ! dopamine receptor activity

[Term]
id: GO:0001592
name: dopamine D3 receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D3 receptors." [IUPHAR_RECEPTOR:2256]
is_a: GO:0001591 ! dopamine receptor activity, coupled via Gi/Go

[Term]
id: GO:0001593
name: dopamine D4 receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D4 receptors." [IUPHAR_RECEPTOR:2258]
is_a: GO:0001591 ! dopamine receptor activity, coupled via Gi/Go

[Term]
id: GO:0001594
name: trace-amine receptor activity
namespace: molecular_function
is_a: GO:0008227 ! G-protein coupled amine receptor activity

[Term]
id: GO:0001595
name: angiotensin receptor activity
namespace: molecular_function
def: "Combining with angiotensin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0001596
name: angiotensin type I receptor activity
namespace: molecular_function
is_a: GO:0001595 ! angiotensin receptor activity

[Term]
id: GO:0001597
name: apelin-like receptor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because the function it represents does not exist.
synonym: "APJ-like receptor" EXACT []
is_obsolete: true
consider: GO:0031704

[Term]
id: GO:0001598
name: chemokine receptor-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
is_obsolete: true

[Term]
id: GO:0001599
name: endothelin-A receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that preferentially binds endothelin 1." [IUPHAR_RECEPTOR:2263, PMID:8582288]
is_a: GO:0004962 ! endothelin receptor activity

[Term]
id: GO:0001600
name: endothelin-B receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that binds all endothelin molecules with approximately equal affinity." [IUPHAR_RECEPTOR:2265, PMID:8582288]
is_a: GO:0004962 ! endothelin receptor activity

[Term]
id: GO:0001601
name: peptide YY receptor activity
namespace: molecular_function
def: "Combining with gut peptide YY to initiate a change in cell activity." [PMID:9315606]
is_a: GO:0004983 ! neuropeptide Y receptor activity

[Term]
id: GO:0001602
name: pancreatic polypeptide receptor activity
namespace: molecular_function
def: "Combining with pancreatic polypeptide PP to initiate a change in cell activity." [PMID:9315606]
is_a: GO:0004983 ! neuropeptide Y receptor activity

[Term]
id: GO:0001603
name: vasopressin-like receptor activity
namespace: molecular_function
is_obsolete: true

[Term]
id: GO:0001604
name: urotensin II receptor activity
namespace: molecular_function
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0001605
name: adrenomedullin receptor activity
namespace: molecular_function
def: "Combining with adrenomedullin to initiate a change in cell activity." [GOC:ai]
synonym: "G10D receptor" NARROW []
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0001606
name: GPR37/endothelin B-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
is_obsolete: true

[Term]
id: GO:0001607
name: neuromedin U receptor activity
namespace: molecular_function
def: "Combining with neuromedin U to initiate a change in cell activity." [GOC:ai]
synonym: "NMUR activity" EXACT []
is_a: GO:0008188 ! neuropeptide receptor activity
is_a: GO:0042924 ! neuromedin U binding

[Term]
id: GO:0001608
name: nucleotide receptor activity, G-protein coupled
namespace: molecular_function
def: "A GPCR that binds a nucleotide or nucleotide derivative as its ligand." [GOC:dph, IUPHAR_GPCR:1294]
synonym: "G protein coupled nucleotide receptor activity" EXACT []
synonym: "G-protein-coupled nucleotide receptor activity" EXACT []
synonym: "nucleotide receptor activity, G protein coupled" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001609
name: adenosine receptor activity, G-protein coupled
namespace: molecular_function
alt_id: GO:0001610
alt_id: GO:0001611
alt_id: GO:0001612
alt_id: GO:0001613
alt_id: GO:0008501
def: "Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:mah, PMID:9755289]
synonym: "A1 adenosine receptor activity, G protein coupled" NARROW []
synonym: "A1 adenosine receptor activity, G-protein coupled" NARROW []
synonym: "A2A adenosine receptor activity, G protein coupled" NARROW []
synonym: "A2A adenosine receptor activity, G-protein coupled" NARROW []
synonym: "A2B adenosine receptor activity, G protein coupled" NARROW []
synonym: "A2B adenosine receptor activity, G-protein coupled" NARROW []
synonym: "A3 adenosine receptor activity, G protein coupled" NARROW []
synonym: "A3 adenosine receptor activity, G-protein coupled" NARROW []
synonym: "adenosine nucleotide receptor" BROAD []
synonym: "adenosine receptor activity, G protein coupled" EXACT []
synonym: "G protein coupled A1 adenosine receptor activity" NARROW []
synonym: "G protein coupled A2A adenosine receptor activity" NARROW []
synonym: "G protein coupled A2B adenosine receptor activity" NARROW []
synonym: "G protein coupled A3 adenosine receptor activity" NARROW []
synonym: "G protein coupled adenosine receptor activity" EXACT []
synonym: "G-protein-coupled A1 adenosine receptor activity" NARROW []
synonym: "G-protein-coupled A2A adenosine receptor activity" NARROW []
synonym: "G-protein-coupled A2B adenosine receptor activity" NARROW []
synonym: "G-protein-coupled A3 adenosine receptor activity" NARROW []
synonym: "G-protein-coupled adenosine receptor activity" EXACT []
xref: Reactome:71 "adenosine receptor activity, G-protein coupled"
is_a: GO:0045028 ! purinergic nucleotide receptor activity, G-protein coupled

[Term]
id: GO:0001614
name: purinergic nucleotide receptor activity
namespace: molecular_function
def: "Combining with a purine nucleotide to initiate a change in cell activity." [GOC:mah]
synonym: "P2Y receptor" NARROW []
synonym: "purinoceptor" BROAD []
synonym: "purinoreceptor" BROAD []
is_a: GO:0016502 ! nucleotide receptor activity

[Term]
id: GO:0001615
name: thyrotropin releasing hormone and secretagogue-like receptors activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
is_obsolete: true

[Term]
id: GO:0001616
name: growth hormone secretagogue receptor activity
namespace: molecular_function
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001617
name: growth hormone secretagogue-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
is_obsolete: true

[Term]
id: GO:0001618
name: viral receptor activity
namespace: molecular_function
def: "Combining with a virus component to initiate a change in cell activity." [GOC:dph]
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0001619
name: lysosphingolipid and lysophosphatidic acid receptor activity
namespace: molecular_function
def: "Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity." [GOC:dph]
is_a: GO:0045125 ! bioactive lipid receptor activity

[Term]
id: GO:0001621
name: platelet ADP receptor activity
namespace: molecular_function
synonym: "K101 receptor" NARROW []
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001622
name: super conserved receptor expressed in brain receptor activity
namespace: molecular_function
synonym: "SREB receptor" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001623
name: Mas proto-oncogene receptor activity
namespace: molecular_function
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001624
name: RDC1 receptor activity
namespace: molecular_function
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001625
name: Epstein-Barr Virus-induced receptor activity
namespace: molecular_function
synonym: "EBV-induced receptor" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001626
name: nociceptin/orphanin-FQ receptor activity
namespace: molecular_function
synonym: "ORPH receptor" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001627
name: leucine-rich G-protein receptor-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "leucine-rich G protein receptor-like receptor activity" EXACT []
synonym: "LGR-like receptor" EXACT []
is_obsolete: true

[Term]
id: GO:0001628
name: gastropyloric receptor activity
namespace: molecular_function
synonym: "GPR receptor" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001629
name: G-protein receptor 45-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "G protein receptor 45-like receptor activity" EXACT []
synonym: "GPR45-like receptor" EXACT []
is_obsolete: true

[Term]
id: GO:0001630
name: GP40-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
is_obsolete: true

[Term]
id: GO:0001631
name: cysteinyl leukotriene receptor activity
namespace: molecular_function
def: "Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide moiety based on cysteine." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "CysLT receptor" EXACT []
is_a: GO:0004974 ! leukotriene receptor activity

[Term]
id: GO:0001632
name: leukotriene B4 receptor activity
namespace: molecular_function
def: "Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "BLT receptor" NARROW []
is_a: GO:0004974 ! leukotriene receptor activity

[Term]
id: GO:0001633
name: secretin-like receptor activity
namespace: molecular_function
alt_id: GO:0001638
def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the secretin receptor." [GOC:mah, IUPHAR_GPCR:1506]
comment: This term was made obsolete because it represents a gene product and is named based on protein features.
synonym: "class B G protein coupled receptor" EXACT []
synonym: "class B G-protein coupled receptor" EXACT []
synonym: "class B GPCR" EXACT []
synonym: "class B orphan receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0001634
name: pituitary adenylate cyclase-activating polypeptide receptor activity
namespace: molecular_function
alt_id: GO:0016522
def: "A G-protein coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide." [GOC:dph, GOC:tb]
synonym: "PACAP receptor" EXACT []
synonym: "pituitary adenylate cyclase activating polypeptide receptor" EXACT []
synonym: "pituitary adenylate cyclase activating protein receptor activity" EXACT [GOC:dph, GOC:tb]
synonym: "pituitary adenylate cyclase-activating peptide receptor activity" RELATED []
synonym: "pituitary adenylate cyclase-activating polypeptide receptor activity" RELATED []
synonym: "pituitary adenylyl cyclase activating protein receptor activity" EXACT []
xref: Reactome:272 "pituitary adenylate cyclase-activating polypeptide receptor activity"
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001635
name: calcitonin gene-related polypeptide receptor activity
namespace: molecular_function
synonym: "CGRP receptor" EXACT []
xref: Wikipedia:CALCRL
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0001636
name: corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
is_obsolete: true

[Term]
id: GO:0001637
name: G-protein chemoattractant receptor activity
namespace: molecular_function
synonym: "G protein chemoattractant receptor activity" EXACT []
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0001639
name: PLC activating metabotropic glutamate receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system." [PMID:9016303]
synonym: "Group I metabotropic glutamate receptor" RELATED []
synonym: "group I metabotropic glutamate receptor activity" RELATED []
synonym: "phospholipase C activating metabotropic glutamate receptor activity" EXACT []
is_a: GO:0008066 ! glutamate receptor activity

[Term]
id: GO:0001640
name: adenylate cyclase inhibiting metabotropic glutamate receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that binds glutamate and inhibits adenylate cyclase activity." [GOC:dph]
synonym: "adenylyl cyclase inhibiting metabotropic glutamate receptor activity" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity
is_a: GO:0008066 ! glutamate receptor activity

[Term]
id: GO:0001641
name: group II metabotropic glutamate receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity." [GOC:dph]
is_a: GO:0001640 ! adenylate cyclase inhibiting metabotropic glutamate receptor activity

[Term]
id: GO:0001642
name: group III metabotropic glutamate receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity." [PMID:9016303]
is_a: GO:0001640 ! adenylate cyclase inhibiting metabotropic glutamate receptor activity

[Term]
id: GO:0001646
name: cAMP receptor activity
namespace: molecular_function
alt_id: GO:0001644
def: "Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) to initiate a change in cell activity." [GOC:pg]
synonym: "3',5' cAMP receptor activity" EXACT []
synonym: "3',5'-cAMP receptor activity" EXACT []
synonym: "adenosine 3',5'-cyclophosphate receptor activity" EXACT []
synonym: "class E G protein coupled receptor" BROAD []
synonym: "class E G-protein coupled receptor" BROAD []
synonym: "class E GPCR" BROAD []
synonym: "cyclic AMP receptor activity" EXACT []
is_a: GO:0016502 ! nucleotide receptor activity
is_a: GO:0030552 ! cAMP binding

[Term]
id: GO:0001647
name: G-protein coupled cytokinin receptor activity
namespace: molecular_function
def: "Combining with a cytokinin to initiate a change in cell activity. The receptor is G-protein coupled." [GOC:dph]
synonym: "G protein coupled cytokinin receptor activity" EXACT []
synonym: "G-protein-coupled cytokinin receptor activity" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity
is_a: GO:0009884 ! cytokinin receptor activity

[Term]
id: GO:0001648
name: proteinase activated receptor activity
namespace: molecular_function
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0001649
name: osteoblast differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone." [GOC:jic, http://cancerweb.ncl.ac.uk]
synonym: "osteoblast cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001503 ! ossification

[Term]
id: GO:0001650
name: fibrillar center
namespace: cellular_component
def: "A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures." [PMID:10754561]
synonym: "fibrillar centre" EXACT []
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0001651
name: dense fibrillar component
namespace: cellular_component
def: "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561]
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0001652
name: granular component
namespace: cellular_component
def: "A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm." [PMID:10754561]
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0001653
name: peptide receptor activity
namespace: molecular_function
def: "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl]
synonym: "endogenous peptide receptor activity" NARROW []
synonym: "exogenous peptide receptor activity" NARROW []
is_a: GO:0004872 ! receptor activity
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0001654
name: eye development
namespace: biological_process
alt_id: GO:0042460
def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jic, GOC:jl]
xref: Wikipedia:Eye_development
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0001655
name: urogenital system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048731 ! system development

[Term]
id: GO:0001656
name: metanephros development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord." [GOC:bf, ISBN:0192800752]
is_a: GO:0001822 ! kidney development

[Term]
id: GO:0001657
name: ureteric bud development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0001658
name: branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "The process by which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, PMID:16916378]
synonym: "ureteric bud branching" EXACT [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of a tube
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0060675 ! ureteric bud morphogenesis

[Term]
id: GO:0001659
name: temperature homeostasis
namespace: biological_process
def: "A homeostatic process by which an organism modulates its internal body temperature." [GOC:jl]
synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Thermoregulation
is_a: GO:0048871 ! multicellular organismal homeostasis

[Term]
id: GO:0001660
name: fever
namespace: biological_process
def: "A rise in body temperature above the normal, often as a response to infection." [GOC:jl]
synonym: "pyrexia" BROAD []
xref: Wikipedia:Fever
is_a: GO:0006953 ! acute-phase response
is_a: GO:0031649 ! heat generation

[Term]
id: GO:0001661
name: conditioned taste aversion
namespace: biological_process
def: "A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659]
xref: Wikipedia:Conditioned_taste_aversion
xref: Wikipedia:Taste_aversion
is_a: GO:0007631 ! feeding behavior
is_a: GO:0008306 ! associative learning

[Term]
id: GO:0001662
name: behavioral fear response
namespace: biological_process
def: "An acute behavioral change resulting from a perceived external threat." [GOC:dph, PMID:9920659]
synonym: "behavioural fear response" EXACT []
is_a: GO:0002209 ! behavioral defense response
is_a: GO:0042596 ! fear response

[Term]
id: GO:0001664
name: G-protein-coupled receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a G-protein-coupled receptor." [GOC:ceb, GOC:dph]
synonym: "G protein coupled receptor binding" EXACT []
synonym: "G protein coupled receptor ligand" NARROW []
synonym: "G-protein-coupled receptor ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0001665
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein." [EC:2.4.99.3]
synonym: "CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.3]
synonym: "GalNAc alpha-2,6-sialyltransferase I activity" EXACT [EC:2.4.99.3]
xref: EC:2.4.99.3
xref: MetaCyc:2.4.99.3-RXN
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0001666
name: response to hypoxia
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd]
comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
synonym: "response to hypoxic stress" EXACT []
synonym: "response to lowered oxygen tension" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0070482 ! response to oxygen levels

[Term]
id: GO:0001667
name: ameboidal cell migration
namespace: biological_process
def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph]
synonym: "ameboid cell migration" EXACT []
synonym: "amoeboid cell migration" EXACT []
synonym: "amoeboidal cell migration" EXACT []
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0001669
name: acrosomal vesicle
namespace: cellular_component
def: "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "acrosome" RELATED [GOC:dph]
xref: Wikipedia:Acrosome
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0001670
name: dopamine D2 receptor activity
namespace: molecular_function
def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D2 receptors." [IUPHAR_RECEPTOR:2254]
is_a: GO:0001591 ! dopamine receptor activity, coupled via Gi/Go

[Term]
id: GO:0001671
name: ATPase activator activity
namespace: molecular_function
def: "Functions to increase the rate of ATP hydrolysis." [GOC:ajp]
synonym: "ATPase stimulator activity" EXACT []
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0060590 ! ATPase regulator activity

[Term]
id: GO:0001672
name: regulation of chromatin assembly or disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators]
synonym: "regulation of chromatin assembly/disassembly" EXACT []
is_a: GO:0033044 ! regulation of chromosome organization
relationship: regulates GO:0006333 ! chromatin assembly or disassembly

[Term]
id: GO:0001673
name: male germ cell nucleus
namespace: cellular_component
alt_id: GO:0043081
def: "The nucleus of a male germ cell, a reproductive cell in males." [GOC:hjd, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk]
synonym: "male germ-cell nucleus" EXACT []
is_a: GO:0043073 ! germ cell nucleus

[Term]
id: GO:0001674
name: female germ cell nucleus
namespace: cellular_component
alt_id: GO:0043080
def: "The nucleus of the female germ cell, a reproductive cell in females." [GOC:hjd, http://cancerweb.ncl.ac.uk]
synonym: "female germ-cell nucleus" EXACT []
is_a: GO:0043073 ! germ cell nucleus

[Term]
id: GO:0001675
name: acrosome assembly
namespace: biological_process
def: "The formation of the acrosome from the spermatid Golgi." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "acrosome formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0001676
name: long-chain fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18." [GOC:ajp]
subset: gosubset_prok
synonym: "long-chain fatty acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0001677
name: formation of translation initiation ternary complex
namespace: biological_process
def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd]
subset: gosubset_prok
synonym: "translation initiation ternary complex assembly" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0006413 ! translational initiation

[Term]
id: GO:0001678
name: cellular glucose homeostasis
namespace: biological_process
def: "A cellular homeostatic process involved in the maintenance of an internal equilibrium of glucose within a cell or between a cell and its external environment." [GOC:dph, GOC:go_curators, GOC:tb]
subset: gosubset_prok
synonym: "cell glucose homeostasis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042593 ! glucose homeostasis
is_a: GO:0055082 ! cellular chemical homeostasis

[Term]
id: GO:0001680
name: tRNA 3'-terminal CCA addition
namespace: biological_process
def: "Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0042780 ! tRNA 3'-end processing

[Term]
id: GO:0001681
name: sialate O-acetylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate." [EC:3.1.1.53, PMID:1991039]
subset: gosubset_prok
synonym: "N-acetylneuraminate acetyltransferase activity" EXACT [EC:3.1.1.53]
synonym: "N-acyl-O-acetylneuraminate O-acetylhydrolase activity" EXACT [EC:3.1.1.53]
synonym: "sialate 9(4)-O-acetylesterase activity" EXACT []
xref: EC:3.1.1.53
xref: MetaCyc:SIALATE-O-ACETYLESTERASE-RXN
is_a: GO:0008126 ! acetylesterase activity

[Term]
id: GO:0001682
name: tRNA 5'-leader removal
namespace: biological_process
def: "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395]
subset: gosubset_prok
synonym: "tRNA 5' leader removal" EXACT []
is_a: GO:0008033 ! tRNA processing

[Term]
id: GO:0001683
name: axonemal dynein heavy chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005858

[Term]
id: GO:0001684
name: axonemal dynein intermediate chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005858

[Term]
id: GO:0001685
name: axonemal dynein intermediate light chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005858

[Term]
id: GO:0001686
name: axonemal dynein light chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005858

[Term]
id: GO:0001687
name: cytoplasmic dynein heavy chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005868

[Term]
id: GO:0001688
name: cytoplasmic dynein intermediate chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005868

[Term]
id: GO:0001689
name: cytoplasmic dynein intermediate light chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005868

[Term]
id: GO:0001690
name: cytoplasmic dynein light chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005868

[Term]
id: GO:0001691
name: pseudophosphatase activity
namespace: molecular_function
def: "Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues." [GOC:ajp]
is_a: GO:0019212 ! phosphatase inhibitor activity

[Term]
id: GO:0001692
name: histamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
synonym: "histamine metabolism" EXACT []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0001694
name: histamine biosynthetic process
namespace: biological_process
alt_id: GO:0001693
def: "The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
synonym: "histamine anabolism" EXACT []
synonym: "histamine biosynthesis" EXACT []
synonym: "histamine formation" EXACT []
synonym: "histamine synthesis" EXACT []
is_a: GO:0001692 ! histamine metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process

[Term]
id: GO:0001695
name: histamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172]
synonym: "histamine breakdown" EXACT []
synonym: "histamine catabolism" EXACT []
synonym: "histamine degradation" EXACT []
is_a: GO:0001692 ! histamine metabolic process
is_a: GO:0042135 ! neurotransmitter catabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0001696
name: gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd]
synonym: "hydrochloric acid secretion" NARROW []
is_a: GO:0022600 ! digestive system process
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0001697
name: histamine-induced gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP." [GOC:hjd]
is_a: GO:0001696 ! gastric acid secretion

[Term]
id: GO:0001698
name: gastrin-induced gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid induced by the interaction of gastrin with its receptor." [GOC:hjd]
is_a: GO:0001696 ! gastric acid secretion

[Term]
id: GO:0001699
name: acetylcholine-induced gastric acid secretion
namespace: biological_process
def: "The regulated release of gastric acid by parietal cells in response to acetylcholine." [GOC:hjd]
is_a: GO:0001696 ! gastric acid secretion

[Term]
id: GO:0001700
name: embryonic development via the syncytial blastoderm
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0009792 ! embryonic development ending in birth or egg hatching

[Term]
id: GO:0001701
name: in utero embryonic development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0043009 ! chordate embryonic development

[Term]
id: GO:0001702
name: gastrulation with mouth forming second
namespace: biological_process
alt_id: GO:0010003
alt_id: GO:0048276
def: "A gastrulation process in which the initial invagination becomes the anus and the mouth forms second." [GOC:go_curators, GOC:mtg_sensu]
synonym: "deuterostomic gastrulation" EXACT [GOC:dph]
is_a: GO:0007369 ! gastrulation

[Term]
id: GO:0001703
name: gastrulation with mouth forming first
namespace: biological_process
def: "A gastrulation process in which the initial invagination becomes the mouth and the anus forms second." [GOC:go_curators, GOC:mtg_sensu]
synonym: "protostomic gastrulation" EXACT [GOC:dph]
is_a: GO:0007369 ! gastrulation

[Term]
id: GO:0001704
name: formation of primary germ layer
namespace: biological_process
def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007369 ! gastrulation

[Term]
id: GO:0001705
name: ectoderm formation
namespace: biological_process
def: "The formation of ectoderm during gastrulation." [GOC:go_curators]
is_a: GO:0001704 ! formation of primary germ layer
relationship: part_of GO:0007398 ! ectoderm development

[Term]
id: GO:0001706
name: endoderm formation
namespace: biological_process
def: "The formation of the endoderm during gastrulation." [GOC:go_curators]
synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001704 ! formation of primary germ layer
relationship: part_of GO:0007492 ! endoderm development

[Term]
id: GO:0001707
name: mesoderm formation
namespace: biological_process
def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators]
is_a: GO:0001704 ! formation of primary germ layer
relationship: part_of GO:0048332 ! mesoderm morphogenesis

[Term]
id: GO:0001708
name: cell fate specification
namespace: biological_process
def: "The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators]
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0045165 ! cell fate commitment

[Term]
id: GO:0001709
name: cell fate determination
namespace: biological_process
def: "Process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437]
xref: Wikipedia:Cell_fate_determination
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0045165 ! cell fate commitment

[Term]
id: GO:0001710
name: mesodermal cell fate commitment
namespace: biological_process
def: "The process by which a cell becomes committed to become part of the mesoderm." [GOC:go_curators, ISBN:0878932437]
synonym: "mesoderm cell fate commitment" EXACT []
is_a: GO:0060795 ! cell fate commitment involved in the formation of primary germ layers
relationship: part_of GO:0048333 ! mesodermal cell differentiation

[Term]
id: GO:0001711
name: endodermal cell fate commitment
namespace: biological_process
def: "The process by which a cell becomes committed to become part of the endoderm." [GOC:go_curators, ISBN:0878932437]
synonym: "endoderm cell fate commitment" EXACT []
is_a: GO:0060795 ! cell fate commitment involved in the formation of primary germ layers
relationship: part_of GO:0001706 ! endoderm formation

[Term]
id: GO:0001712
name: ectodermal cell fate commitment
namespace: biological_process
def: "The process by which a cell becomes committed to become part of the ectoderm." [GOC:go_curators, ISBN:0878932437]
synonym: "ectoderm cell fate commitment" EXACT []
is_a: GO:0060795 ! cell fate commitment involved in the formation of primary germ layers
relationship: part_of GO:0001705 ! ectoderm formation
relationship: part_of GO:0010668 ! ectodermal cell differentiation

[Term]
id: GO:0001713
name: ectodermal cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437]
synonym: "ectoderm cell fate determination" EXACT []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0001712 ! ectodermal cell fate commitment

[Term]
id: GO:0001714
name: endodermal cell fate specification
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
synonym: "endoderm cell fate specification" EXACT []
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0001711 ! endodermal cell fate commitment

[Term]
id: GO:0001715
name: ectodermal cell fate specification
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
synonym: "ectoderm cell fate specification" EXACT []
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0001712 ! ectodermal cell fate commitment

[Term]
id: GO:0001716
name: L-amino-acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2." [EC:1.4.3.2]
subset: gosubset_prok
synonym: "L-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.2]
synonym: "ophio-amino-acid oxidase activity" EXACT [EC:1.4.3.2]
xref: EC:1.4.3.2
xref: MetaCyc:L-AMINO-ACID-OXIDASE-RXN
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0001717
name: conversion of seryl-tRNAsec to selenocys-tRNAsec
namespace: biological_process
def: "Process whereby serine carried by a specialized tRNA(ser) (which can read a UGA anticodon) is converted to selenocysteine." [ISBN:155581073X]
subset: gosubset_prok
is_a: GO:0019988 ! charged-tRNA amino acid modification

[Term]
id: GO:0001720
name: conversion of lysyl-tRNA to pyrrolysyl-tRNA
namespace: biological_process
def: "Process whereby lysine carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon) is converted to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate)." [PMID:12029131, PMID:12029132, PMID:12121639]
subset: gosubset_prok
is_a: GO:0019988 ! charged-tRNA amino acid modification

[Term]
id: GO:0001721
name: intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "IFAP" EXACT []
is_obsolete: true
replaced_by: GO:0005882

[Term]
id: GO:0001722
name: type I intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005882

[Term]
id: GO:0001723
name: type II intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005882

[Term]
id: GO:0001724
name: type III intermediate filament associated protein
namespace: cellular_component
def: "OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane." [GOC:ajp, PMID:9484600]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0045098

[Term]
id: GO:0001725
name: stress fiber
namespace: cellular_component
def: "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381]
synonym: "actin cable" RELATED [GOC:mah]
synonym: "stress fibre" EXACT []
is_a: GO:0032432 ! actin filament bundle
is_a: GO:0042641 ! actomyosin

[Term]
id: GO:0001726
name: ruffle
namespace: cellular_component
def: "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653]
synonym: "membrane ruffle" RELATED []
is_a: GO:0042995 ! cell projection
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0001727
name: lipid kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of a simple or complex lipid." [GOC:hjd]
subset: gosubset_prok
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0001729
name: ceramide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + ceramide = ADP + ceramide 1-phosphate." [EC:2.7.1.138]
synonym: "acylsphingosine kinase activity" EXACT [EC:2.7.1.138]
synonym: "ATP:ceramide 1-phosphotransferase activity" EXACT [EC:2.7.1.138]
xref: EC:2.7.1.138
xref: MetaCyc:CERAMIDE-KINASE-RXN
is_a: GO:0001727 ! lipid kinase activity

[Term]
id: GO:0001730
name: 2'-5'-oligoadenylate synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. Requires binding of double-stranded RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "(2-5')oligo(A) synthetase activity" EXACT []
synonym: "2'-5' oligoadenylate synthetase activity" EXACT []
synonym: "2-5A synthetase activity" EXACT []
synonym: "oligo-2',5'-adenylate synthetase activity" EXACT []
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0001731
name: formation of translation preinitiation complex
namespace: biological_process
def: "The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd]
comment: See also the cellular component terms 'eukaryotic 43S preinitiation complex ; GO:0016282', 'eukaryotic 48S initiation complex ; GO:0033290', and their children.
subset: gosubset_prok
synonym: "formation of translation pre-initiation complex" EXACT []
synonym: "translation preinitiation complex assembly" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0006413 ! translational initiation

[Term]
id: GO:0001732
name: formation of translation initiation complex
namespace: biological_process
def: "Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd]
subset: gosubset_prok
synonym: "translation initiation complex assembly" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0006413 ! translational initiation

[Term]
id: GO:0001733
name: galactosylceramide sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate." [EC:2.8.2.11, PMID:10727929]
synonym: "3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "cerebroside sulfotransferase activity" EXACT []
synonym: "galactocerebroside sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "galactolipid sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "galactosylceramide sulphotransferase activity" EXACT []
synonym: "glycolipid sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "glycosphingolipid sulfotransferase activity" EXACT [EC:2.8.2.11]
synonym: "GSase" EXACT [EC:2.8.2.11]
xref: EC:2.8.2.11
xref: MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN
is_a: GO:0050694 ! galactose 3-O-sulfotransferase activity

[Term]
id: GO:0001734
name: mRNA (N6-adenosine)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R = purine, and H = C, A, or U." [GOC:hjd]
xref: Reactome:2399 "mRNA (N6-adenosine)-methyltransferase activity"
is_a: GO:0008174 ! mRNA methyltransferase activity

[Term]
id: GO:0001735
name: prenylcysteine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H20 = a prenal + L-cysteine + H202." [GOC:hjd]
synonym: "prenylcysteine lyase activity" EXACT [EC:1.8.3.5]
synonym: "S-prenyl-L-cysteine:oxygen oxidoreductase activity" EXACT [EC:1.8.3.5]
xref: EC:1.8.3.5
xref: MetaCyc:1.8.3.5-RXN
is_a: GO:0016670 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0001736
name: establishment of planar polarity
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph]
synonym: "establishment of planar cell polarity" NARROW []
is_a: GO:0007164 ! establishment of tissue polarity
relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium

[Term]
id: GO:0001737
name: establishment of imaginal disc-derived wing hair orientation
namespace: biological_process
def: "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465]
synonym: "establishment of wing hair orientation" EXACT []
is_a: GO:0001736 ! establishment of planar polarity
relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization

[Term]
id: GO:0001738
name: morphogenesis of a polarized epithelium
namespace: biological_process
def: "The process by which the anatomical structures of polarized epithelium are generated and organized. Morphogenesis pertains to the creation of form. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph]
synonym: "epithelial polarization" EXACT [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0001739
name: sex chromatin
namespace: cellular_component
def: "A condensed mass of compacted chromatin that represents an inactivated X chromosome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0005720 ! nuclear heterochromatin
relationship: part_of GO:0000803 ! sex chromosome

[Term]
id: GO:0001740
name: Barr body
namespace: cellular_component
def: "A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd]
xref: Wikipedia:Barr_body
is_a: GO:0000805 ! X chromosome
is_a: GO:0001739 ! sex chromatin

[Term]
id: GO:0001741
name: XY body
namespace: cellular_component
def: "A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd]
is_a: GO:0001739 ! sex chromatin

[Term]
id: GO:0001742
name: oenocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:go_curators]
synonym: "oenocyte cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0001743
name: optic placode formation
namespace: biological_process
def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0001744
name: optic lobe placode formation
namespace: biological_process
alt_id: GO:0007457
def: "Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833]
synonym: "optic lobe and Bolwig's organ precursor formation" EXACT []
is_a: GO:0001743 ! optic placode formation
relationship: part_of GO:0001748 ! optic lobe placode development

[Term]
id: GO:0001745
name: compound eye morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the compound eye are generated and organized. Morphogenesis pertains to the creation of form. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu]
synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386]
is_a: GO:0048592 ! eye morphogenesis
relationship: part_of GO:0048749 ! compound eye development

[Term]
id: GO:0001746
name: Bolwig's organ morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the larval eye in Drosophila are generated and organized. Morphogenesis pertains to the creation of form. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380]
is_a: GO:0048592 ! eye morphogenesis
relationship: part_of GO:0055034 ! Bolwig's organ development

[Term]
id: GO:0001748
name: optic lobe placode development
namespace: biological_process
alt_id: GO:0048049
def: "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833]
synonym: "optic lobe and Bolwig's organ precursor development" EXACT []
synonym: "optic placode development" BROAD []
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0001750
name: photoreceptor outer segment
namespace: cellular_component
def: "The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes." [ISBN:0824072820]
is_a: GO:0031513 ! nonmotile primary cilium

[Term]
id: GO:0001751
name: compound eye photoreceptor cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators]
is_a: GO:0001754 ! eye photoreceptor cell differentiation
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0001752
name: compound eye photoreceptor fate commitment
namespace: biological_process
alt_id: GO:0007459
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
is_a: GO:0042706 ! eye photoreceptor cell fate commitment
relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0001753
name: adult eye photoreceptor development (sensu Drosophila)
namespace: biological_process
def: "OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye." [GOC:go_curators]
comment: This term was made obsolete because eye photoreceptors have completed their development by the time the adult phase begins.
is_obsolete: true
consider: GO:0042051

[Term]
id: GO:0001754
name: eye photoreceptor cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators]
is_a: GO:0046530 ! photoreceptor cell differentiation
relationship: part_of GO:0048592 ! eye morphogenesis

[Term]
id: GO:0001755
name: neural crest cell migration
namespace: biological_process
def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437]
is_a: GO:0001667 ! ameboidal cell migration
relationship: part_of GO:0014032 ! neural crest cell development

[Term]
id: GO:0001756
name: somitogenesis
namespace: biological_process
def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "formation of mesodermal clusters" EXACT systematic_synonym []
xref: Wikipedia:Somitogenesis
is_a: GO:0009952 ! anterior/posterior pattern formation
is_a: GO:0035282 ! segmentation
relationship: part_of GO:0043009 ! chordate embryonic development

[Term]
id: GO:0001757
name: somite specification
namespace: biological_process
def: "The process by which individual somites establish identity during embryogenesis." [GOC:dph]
is_a: GO:0007379 ! segment specification
relationship: part_of GO:0001756 ! somitogenesis

[Term]
id: GO:0001758
name: retinal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal." [EC:1.2.1.36]
synonym: "cytosolic retinal dehydrogenase activity" EXACT [EC:1.2.1.36]
synonym: "retinal:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.36]
xref: EC:1.2.1.36
xref: MetaCyc:RETINAL-DEHYDROGENASE-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0001759
name: induction of an organ
namespace: biological_process
def: "The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ." [ISBN:0878932437]
is_a: GO:0031128 ! developmental induction
relationship: positively_regulates GO:0010092 ! specification of organ identity

[Term]
id: GO:0001760
name: aminocarboxymuconate-semialdehyde decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate = 2-aminomuconate semialdehyde + CO2." [EC:4.1.1.45]
subset: gosubset_prok
synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)" EXACT [EC:4.1.1.45]
synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45]
synonym: "2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45]
synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity" EXACT [EC:4.1.1.45]
synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity" EXACT [EC:4.1.1.45]
synonym: "picolinic acid carboxylase activity" EXACT [EC:4.1.1.45]
synonym: "picolinic acid decarboxylase activity" EXACT [EC:4.1.1.45]
xref: EC:4.1.1.45
xref: MetaCyc:AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0001761
name: beta-alanine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid." [GOC:hjd]
synonym: "beta-alanine transporter activity" BROAD []
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity

[Term]
id: GO:0001762
name: beta-alanine transport
namespace: biological_process
def: "The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:hjd]
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0001763
name: morphogenesis of a branching structure
namespace: biological_process
def: "The process by which the anatomical structures of branches are generated and organized. Morphogenesis pertains to the creation of form. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0001764
name: neuron migration
namespace: biological_process
def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [GOC:go_curators]
synonym: "neuron chemotaxis" EXACT [GOC:curators]
synonym: "neuron guidance" RELATED [GOC:curators]
synonym: "neuronal migration" EXACT []
xref: Wikipedia:Neural_development#Neuron_migration
xref: Wikipedia:Neuron_migration
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0001765
name: membrane raft assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes." [PMID:12648772, PMID:12803918, PMID:16645198]
synonym: "lipid raft assembly" EXACT [GOC:mah]
synonym: "lipid raft formation" RELATED []
synonym: "membrane raft formation" RELATED [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0031579 ! membrane raft organization

[Term]
id: GO:0001766
name: membrane raft polarization
namespace: biological_process
def: "The clustering and aggregation of membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes." [PMID:12615889]
synonym: "lipid raft polarization" EXACT []
is_a: GO:0031580 ! membrane raft distribution

[Term]
id: GO:0001767
name: establishment of lymphocyte polarity
namespace: biological_process
def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889]
synonym: "lymphocyte polarization" EXACT []
is_a: GO:0030010 ! establishment of cell polarity
relationship: part_of GO:0046649 ! lymphocyte activation

[Term]
id: GO:0001768
name: establishment of T cell polarity
namespace: biological_process
def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889]
synonym: "establishment of T lymphocyte polarity" EXACT []
synonym: "establishment of T-cell polarity" EXACT []
synonym: "establishment of T-lymphocyte polarity" EXACT []
synonym: "T cell polarization" EXACT []
synonym: "T lymphocyte polarization" EXACT []
synonym: "T-cell polarization" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
relationship: part_of GO:0042110 ! T cell activation

[Term]
id: GO:0001769
name: establishment of B cell polarity
namespace: biological_process
def: "The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell." [GOC:mgi_curators, PMID:12615889, PMID:9692889]
comment: Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells.
synonym: "B cell polarization" EXACT []
synonym: "B lymphocyte polarization" EXACT []
synonym: "B-cell polarization" EXACT []
synonym: "establishment of B lymphocyte polarity" EXACT []
synonym: "establishment of B-cell polarity" EXACT []
synonym: "establishment of B-lymphocyte polarity" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
relationship: part_of GO:0042113 ! B cell activation

[Term]
id: GO:0001770
name: establishment of natural killer cell polarity
namespace: biological_process
def: "The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands." [GOC:mgi_curators, PMID:12615886, PMID:9759849]
synonym: "establishment of NK cell polarity" EXACT []
synonym: "natural killer cell polarization" EXACT []
synonym: "NK cell polarization" EXACT []
is_a: GO:0001767 ! establishment of lymphocyte polarity
relationship: part_of GO:0030101 ! natural killer cell activation

[Term]
id: GO:0001771
name: formation of immunological synapse
namespace: biological_process
def: "The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376330]
is_a: GO:0009988 ! cell-cell recognition
relationship: part_of GO:0046649 ! lymphocyte activation

[Term]
id: GO:0001772
name: immunological synapse
namespace: cellular_component
def: "An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376300]
synonym: "c-SMAC" NARROW [PMID:14724296]
synonym: "supramolecular activation cluster" EXACT [PMID:14724296]
xref: Wikipedia:Immunological_synapse
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0001773
name: myeloid dendritic cell activation
namespace: biological_process
def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0001774
name: microglial cell activation
namespace: biological_process
def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949]
is_a: GO:0042116 ! macrophage activation

[Term]
id: GO:0001775
name: cell activation
namespace: biological_process
def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:mgi_curators]
subset: goslim_pir
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0001776
name: leukocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus.
synonym: "immune cell homeostasis" EXACT []
synonym: "leucocyte homeostasis" EXACT []
is_a: GO:0002376 ! immune system process
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0001777
name: T cell homeostatic proliferation
namespace: biological_process
def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"]
synonym: "resting T cell proliferation" EXACT []
synonym: "resting T-cell proliferation" EXACT []
synonym: "T lymphocyte homeostatic proliferation" EXACT []
synonym: "T-cell homeostatic proliferation" EXACT []
synonym: "T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042098 ! T cell proliferation
relationship: part_of GO:0043029 ! T cell homeostasis

[Term]
id: GO:0001778
name: plasma membrane repair
namespace: biological_process
def: "The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress." [GOC:add, PMID:12925704]
is_a: GO:0007009 ! plasma membrane organization
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0001779
name: natural killer cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a natural killer cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "NK cell differentiation" EXACT []
is_a: GO:0030098 ! lymphocyte differentiation
is_a: GO:0030101 ! natural killer cell activation

[Term]
id: GO:0001780
name: neutrophil homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:12752675, PMID:12960266]
comment: Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus.
is_a: GO:0002262 ! myeloid cell homeostasis

[Term]
id: GO:0001781
name: neutrophil apoptosis
namespace: biological_process
def: "The process of apoptosis in neutrophils." [GOC:add, PMID:12752675, PMID:12960266]
synonym: "apoptosis of neutrophils" EXACT []
synonym: "neutrophil programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of neutrophils by apoptosis" EXACT []
synonym: "programmed cell death, neutrophils" EXACT []
is_a: GO:0033028 ! myeloid cell apoptosis
relationship: part_of GO:0001780 ! neutrophil homeostasis

[Term]
id: GO:0001782
name: B cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12956429]
comment: Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus.
synonym: "B lymphocyte homeostasis" EXACT []
synonym: "B-cell homeostasis" EXACT []
synonym: "B-lymphocyte homeostasis" EXACT []
is_a: GO:0002260 ! lymphocyte homeostasis

[Term]
id: GO:0001783
name: B cell apoptosis
namespace: biological_process
def: "The process of apoptosis in B cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "apoptosis of B cells" EXACT []
synonym: "apoptosis of B lymphocytes" EXACT []
synonym: "apoptosis of B-cells" EXACT []
synonym: "apoptosis of B-lymphocytes" EXACT []
synonym: "B cell programmed cell death by apoptosis" EXACT []
synonym: "B lymphocyte apoptosis" EXACT []
synonym: "B lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "B-cell apoptosis" EXACT []
synonym: "B-cell programmed cell death by apoptosis" EXACT []
synonym: "B-lymphocyte apoptosis" EXACT []
synonym: "B-lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of B cells by apoptosis" EXACT []
synonym: "programmed cell death of B lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death of B-cells by apoptosis" EXACT []
synonym: "programmed cell death of B-lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death, B cells" EXACT []
synonym: "programmed cell death, B lymphocytes" EXACT []
synonym: "programmed cell death, B-cells" EXACT []
synonym: "programmed cell death, B-lymphocytes" EXACT []
is_a: GO:0070227 ! lymphocyte apoptosis

[Term]
id: GO:0001784
name: phosphotyrosine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein." [PMID:14636584]
is_a: GO:0045309 ! protein phosphorylated amino acid binding

[Term]
id: GO:0001785
name: prostaglandin J receptor activity
namespace: molecular_function
def: "Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity." [PMID:12878180]
synonym: "PGJ receptor activity" RELATED []
synonym: "PGJ(2) receptor activity" EXACT []
is_a: GO:0004955 ! prostaglandin receptor activity

[Term]
id: GO:0001786
name: phosphatidylserine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:12000961]
is_a: GO:0005543 ! phospholipid binding

[Term]
id: GO:0001787
name: natural killer cell proliferation
namespace: biological_process
def: "The expansion of a natural killer cell population by cell division." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "NK cell proliferation" EXACT []
is_a: GO:0030101 ! natural killer cell activation
is_a: GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0001788
name: antibody-dependent cellular cytotoxicity
namespace: biological_process
def: "Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells." [ISBN:0781735149 "Fundamental Immunology", PMID:11677095, PMID:9581795]
synonym: "ADCC" EXACT []
synonym: "antibody dependent cell death" EXACT []
synonym: "antibody dependent cell killing" EXACT []
synonym: "antibody-dependent cell death" EXACT []
synonym: "antibody-dependent cell killing" EXACT []
synonym: "type VI hypersensitivity" EXACT []
xref: Wikipedia:Antibody-dependent_cell-mediated_cytotoxicity
xref: Wikipedia:Antibody-dependent_cellular_cytotoxicity
is_a: GO:0001794 ! type IIa hypersensitivity
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0006917 ! induction of apoptosis

[Term]
id: GO:0001789
name: G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating)
namespace: biological_process
def: "A G-protein coupled signaling pathway that results in the activation of sphingosine kinase, causing an increase in cellular levels of sphingosine-1-phosphate." [GOC:dph, PMID:14592418]
synonym: "G protein signaling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT []
synonym: "G protein signalling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT []
synonym: "G-protein signalling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0001790
name: polymeric immunoglobulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0001791
name: IgM binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an immunoglobulin of the IgM isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0001792
name: polymeric immunoglobulin receptor activity
namespace: molecular_function
def: "Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001790 ! polymeric immunoglobulin binding
is_a: GO:0019763 ! immunoglobulin receptor activity

[Term]
id: GO:0001793
name: IgM receptor activity
namespace: molecular_function
def: "Combining with an immunoglobulin of the IgM isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001791 ! IgM binding
is_a: GO:0019763 ! immunoglobulin receptor activity

[Term]
id: GO:0001794
name: type IIa hypersensitivity
namespace: biological_process
def: "An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that some type IIb hypersensitivity responses (GO:0001795) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIa hypersensitivity.
is_a: GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0001795
name: type IIb hypersensitivity
namespace: biological_process
def: "An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that some type IIa hypersensitivity response (GO:0001794) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIb hypersensitivity.
synonym: "type V hypersensitivity" EXACT []
is_a: GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0001796
name: regulation of type IIa hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002892 ! regulation of type II hypersensitivity
relationship: regulates GO:0001794 ! type IIa hypersensitivity

[Term]
id: GO:0001797
name: negative regulation of type IIa hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of type IIa hypersensitivity" EXACT []
synonym: "down-regulation of type IIa hypersensitivity" EXACT []
synonym: "downregulation of type IIa hypersensitivity" EXACT []
synonym: "inhibition of type IIa hypersensitivity" NARROW []
is_a: GO:0001796 ! regulation of type IIa hypersensitivity
is_a: GO:0002893 ! negative regulation of type II hypersensitivity
relationship: negatively_regulates GO:0001794 ! type IIa hypersensitivity

[Term]
id: GO:0001798
name: positive regulation of type IIa hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of type IIa hypersensitivity" NARROW []
synonym: "stimulation of type IIa hypersensitivity" NARROW []
synonym: "up regulation of type IIa hypersensitivity" EXACT []
synonym: "up-regulation of type IIa hypersensitivity" EXACT []
synonym: "upregulation of type IIa hypersensitivity" EXACT []
is_a: GO:0001796 ! regulation of type IIa hypersensitivity
is_a: GO:0002894 ! positive regulation of type II hypersensitivity
relationship: positively_regulates GO:0001794 ! type IIa hypersensitivity

[Term]
id: GO:0001799
name: regulation of type IIb hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002892 ! regulation of type II hypersensitivity
relationship: regulates GO:0001795 ! type IIb hypersensitivity

[Term]
id: GO:0001800
name: negative regulation of type IIb hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of type IIb hypersensitivity" EXACT []
synonym: "down-regulation of type IIb hypersensitivity" EXACT []
synonym: "downregulation of type IIb hypersensitivity" EXACT []
synonym: "inhibition of type IIb hypersensitivity" NARROW []
is_a: GO:0001799 ! regulation of type IIb hypersensitivity
is_a: GO:0002893 ! negative regulation of type II hypersensitivity
relationship: negatively_regulates GO:0001795 ! type IIb hypersensitivity

[Term]
id: GO:0001801
name: positive regulation of type IIb hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of type IIb hypersensitivity" NARROW []
synonym: "stimulation of type IIb hypersensitivity" NARROW []
synonym: "up regulation of type IIb hypersensitivity" EXACT []
synonym: "up-regulation of type IIb hypersensitivity" EXACT []
synonym: "upregulation of type IIb hypersensitivity" EXACT []
is_a: GO:0001799 ! regulation of type IIb hypersensitivity
is_a: GO:0002894 ! positive regulation of type II hypersensitivity
relationship: positively_regulates GO:0001795 ! type IIb hypersensitivity

[Term]
id: GO:0001802
name: type III hypersensitivity
namespace: biological_process
def: "An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that the Arthus reaction is an example of type III hypersensitivity.
xref: Wikipedia:Type_III_hypersensitivity
is_a: GO:0002444 ! myeloid leukocyte mediated immunity
is_a: GO:0002524 ! hypersensitivity
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0001803
name: regulation of type III hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002883 ! regulation of hypersensitivity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
relationship: regulates GO:0001802 ! type III hypersensitivity

[Term]
id: GO:0001804
name: negative regulation of type III hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of type III hypersensitivity" EXACT []
synonym: "down-regulation of type III hypersensitivity" EXACT []
synonym: "downregulation of type III hypersensitivity" EXACT []
synonym: "inhibition of type III hypersensitivity" NARROW []
is_a: GO:0001803 ! regulation of type III hypersensitivity
is_a: GO:0002884 ! negative regulation of hypersensitivity
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
relationship: negatively_regulates GO:0001802 ! type III hypersensitivity

[Term]
id: GO:0001805
name: positive regulation of type III hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of type III hypersensitivity" NARROW []
synonym: "stimulation of type III hypersensitivity" NARROW []
synonym: "up regulation of type III hypersensitivity" EXACT []
synonym: "up-regulation of type III hypersensitivity" EXACT []
synonym: "upregulation of type III hypersensitivity" EXACT []
is_a: GO:0001803 ! regulation of type III hypersensitivity
is_a: GO:0002885 ! positive regulation of hypersensitivity
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
relationship: positively_regulates GO:0001802 ! type III hypersensitivity

[Term]
id: GO:0001806
name: type IV hypersensitivity
namespace: biological_process
alt_id: GO:0016069
def: "An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "delayed hypersensitivity response" EXACT []
synonym: "delayed-type hypersensitivity" EXACT []
xref: Wikipedia:Type_IV_hypersensitivity
is_a: GO:0002456 ! T cell mediated immunity
is_a: GO:0002524 ! hypersensitivity

[Term]
id: GO:0001807
name: regulation of type IV hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002883 ! regulation of hypersensitivity
relationship: regulates GO:0001806 ! type IV hypersensitivity

[Term]
id: GO:0001808
name: negative regulation of type IV hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of type IV hypersensitivity" EXACT []
synonym: "down-regulation of type IV hypersensitivity" EXACT []
synonym: "downregulation of type IV hypersensitivity" EXACT []
synonym: "inhibition of type IV hypersensitivity" NARROW []
is_a: GO:0001807 ! regulation of type IV hypersensitivity
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002884 ! negative regulation of hypersensitivity
relationship: negatively_regulates GO:0001806 ! type IV hypersensitivity

[Term]
id: GO:0001809
name: positive regulation of type IV hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of type IV hypersensitivity" NARROW []
synonym: "stimulation of type IV hypersensitivity" NARROW []
synonym: "up regulation of type IV hypersensitivity" EXACT []
synonym: "up-regulation of type IV hypersensitivity" EXACT []
synonym: "upregulation of type IV hypersensitivity" EXACT []
is_a: GO:0001807 ! regulation of type IV hypersensitivity
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002885 ! positive regulation of hypersensitivity
relationship: positively_regulates GO:0001806 ! type IV hypersensitivity

[Term]
id: GO:0001810
name: regulation of type I hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response." [ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002883 ! regulation of hypersensitivity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
relationship: regulates GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0001811
name: negative regulation of type I hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of type I hypersensitivity" EXACT []
synonym: "down-regulation of type I hypersensitivity" EXACT []
synonym: "downregulation of type I hypersensitivity" EXACT []
synonym: "inhibition of type I hypersensitivity" NARROW []
is_a: GO:0001810 ! regulation of type I hypersensitivity
is_a: GO:0002884 ! negative regulation of hypersensitivity
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
relationship: negatively_regulates GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0001812
name: positive regulation of type I hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of type I hypersensitivity" NARROW []
synonym: "stimulation of type I hypersensitivity" NARROW []
synonym: "up regulation of type I hypersensitivity" EXACT []
synonym: "up-regulation of type I hypersensitivity" EXACT []
synonym: "upregulation of type I hypersensitivity" EXACT []
is_a: GO:0001810 ! regulation of type I hypersensitivity
is_a: GO:0002885 ! positive regulation of hypersensitivity
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
relationship: positively_regulates GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0001813
name: regulation of antibody-dependent cellular cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "regulation of antibody dependent cell death" EXACT []
synonym: "regulation of antibody dependent cell killing" EXACT []
synonym: "regulation of antibody-dependent cell death" EXACT []
synonym: "regulation of antibody-dependent cell killing" EXACT []
is_a: GO:0001796 ! regulation of type IIa hypersensitivity
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
relationship: regulates GO:0001788 ! antibody-dependent cellular cytotoxicity

[Term]
id: GO:0001814
name: negative regulation of antibody-dependent cellular cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "down-regulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "downregulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "inhibition of antibody-dependent cellular cytotoxicity" NARROW []
synonym: "negative regulation of antibody dependent cell death" EXACT []
synonym: "negative regulation of antibody dependent cell killing" EXACT []
synonym: "negative regulation of antibody-dependent cell death" EXACT []
synonym: "negative regulation of antibody-dependent cell killing" EXACT []
is_a: GO:0001797 ! negative regulation of type IIa hypersensitivity
is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
relationship: negatively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity

[Term]
id: GO:0001815
name: positive regulation of antibody-dependent cellular cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of antibody-dependent cellular cytotoxicity" NARROW []
synonym: "positive regulation of antibody dependent cell death" EXACT []
synonym: "positive regulation of antibody dependent cell killing" EXACT []
synonym: "positive regulation of antibody-dependent cell death" EXACT []
synonym: "positive regulation of antibody-dependent cell killing" EXACT []
synonym: "stimulation of antibody-dependent cellular cytotoxicity" NARROW []
synonym: "up regulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "up-regulation of antibody-dependent cellular cytotoxicity" EXACT []
synonym: "upregulation of antibody-dependent cellular cytotoxicity" EXACT []
is_a: GO:0001798 ! positive regulation of type IIa hypersensitivity
is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
relationship: positively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity

[Term]
id: GO:0001816
name: cytokine production
namespace: biological_process
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules.
subset: goslim_pir
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0001817
name: regulation of cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0001816 ! cytokine production

[Term]
id: GO:0001818
name: negative regulation of cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of cytokine production" EXACT []
synonym: "down-regulation of cytokine production" EXACT []
synonym: "downregulation of cytokine production" EXACT []
synonym: "inhibition of cytokine production" NARROW []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0001816 ! cytokine production

[Term]
id: GO:0001819
name: positive regulation of cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of cytokine production" NARROW []
synonym: "stimulation of cytokine production" NARROW []
synonym: "up regulation of cytokine production" EXACT []
synonym: "up-regulation of cytokine production" EXACT []
synonym: "upregulation of cytokine production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0001816 ! cytokine production

[Term]
id: GO:0001820
name: serotonin secretion
namespace: biological_process
def: "The regulated release of serotonin by a cell or group of cells. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0781735149 "Fundamental Immunology"]
synonym: "5-HT secretion" EXACT []
synonym: "5-hydroxytryptamine secretion" EXACT []
is_a: GO:0003001 ! generation of a signal involved in cell-cell signaling
is_a: GO:0006837 ! serotonin transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0001821
name: histamine secretion
namespace: biological_process
def: "The regulated release of histamine by a cell or group of cells. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0046903 ! secretion
is_a: GO:0051608 ! histamine transport

[Term]
id: GO:0001822
name: kidney development
namespace: biological_process
def: "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "nephrogenesis" RELATED [GOC:dph, GOC:tb]
xref: Wikipedia:Kidney_development
is_a: GO:0048513 ! organ development
relationship: part_of GO:0072001 ! renal system development

[Term]
id: GO:0001823
name: mesonephros development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney." [GOC:dph, ISBN:0124020607, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:10535314]
is_a: GO:0001822 ! kidney development

[Term]
id: GO:0001824
name: blastocyst development
namespace: biological_process
def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001701 ! in utero embryonic development

[Term]
id: GO:0001825
name: blastocyst formation
namespace: biological_process
def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0001824 ! blastocyst development

[Term]
id: GO:0001826
name: inner cell mass cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'.
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001825 ! blastocyst formation

[Term]
id: GO:0001827
name: inner cell mass cell fate commitment
namespace: biological_process
def: "The cell fate commitment of precursor cells that will become inner cell mass cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, compacted morula ; EMAP:13' and 'TS4, inner cell mass ; EMAP:14'.
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0001826 ! inner cell mass cell differentiation

[Term]
id: GO:0001828
name: inner cell mass cellular morphogenesis
namespace: biological_process
def: "The morphogenesis of cells in the inner cell mass." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001826 ! inner cell mass cell differentiation

[Term]
id: GO:0001829
name: trophectodermal cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.
synonym: "trophectoderm cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001825 ! blastocyst formation

[Term]
id: GO:0001830
name: trophectodermal cell fate commitment
namespace: biological_process
def: "The cell fate commitment of precursor cells that will become trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'.
synonym: "trophectoderm cell fate commitment" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0001829 ! trophectodermal cell differentiation

[Term]
id: GO:0001831
name: trophectodermal cellular morphogenesis
namespace: biological_process
def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
synonym: "trophectoderm cellular morphogenesis" EXACT []
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001829 ! trophectodermal cell differentiation

[Term]
id: GO:0001832
name: blastocyst growth
namespace: biological_process
def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'.
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0001824 ! blastocyst development

[Term]
id: GO:0001833
name: inner cell mass cell proliferation
namespace: biological_process
def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'.
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0001832 ! blastocyst growth

[Term]
id: GO:0001834
name: trophectodermal cell proliferation
namespace: biological_process
def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'.
synonym: "trophectoderm cell proliferation" EXACT []
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0001832 ! blastocyst growth

[Term]
id: GO:0001835
name: blastocyst hatching
namespace: biological_process
def: "The hatching of the cellular blastocyst from the zona pellucida." [GOC:dph, ISBN:0124020607, ISBN:0198542771]
comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, zona pellucida ; EMAP:22' and 'TS5, embryo ; EMAP:23'.
is_a: GO:0035188 ! hatching
relationship: part_of GO:0001824 ! blastocyst development

[Term]
id: GO:0001836
name: release of cytochrome c from mitochondria
namespace: biological_process
def: "The process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:add, GOC:mah, ISBN:0721639976, PMID:12925707, PMID:9560217]
is_a: GO:0008637 ! apoptotic mitochondrial changes

[Term]
id: GO:0001837
name: epithelial to mesenchymal transition
namespace: biological_process
def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881]
synonym: "EMT" EXACT []
synonym: "epithelial-mesenchymal transition" EXACT []
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0014031 ! mesenchymal cell development

[Term]
id: GO:0001838
name: embryonic epithelial tube formation
namespace: biological_process
def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
is_a: GO:0072175 ! epithelial tube formation

[Term]
id: GO:0001839
name: neural plate morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the neural plate are generated and organized. Morphogenesis pertains to the creation of form. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0001840 ! neural plate development

[Term]
id: GO:0001840
name: neural plate development
namespace: biological_process
def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0043009 ! chordate embryonic development

[Term]
id: GO:0001841
name: neural tube formation
namespace: biological_process
alt_id: GO:0001679
def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437]
synonym: "neural tube morphogenesis" EXACT [GOC:dph]
synonym: "neurulation" EXACT []
xref: Wikipedia:Neurulation
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0021915 ! neural tube development

[Term]
id: GO:0001842
name: neural fold formation
namespace: biological_process
def: "The process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0001839 ! neural plate morphogenesis
relationship: part_of GO:0014020 ! primary neural tube formation

[Term]
id: GO:0001843
name: neural tube closure
namespace: biological_process
def: "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline." [GOC:dph, ISBN:0878932437]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0060606 ! tube closure
relationship: part_of GO:0014020 ! primary neural tube formation

[Term]
id: GO:0001844
name: protein insertion into mitochondrial membrane during induction of apoptosis
namespace: biological_process
def: "The process by which a protein is incorporated into a mitochondrial membrane as an early step in apoptosis." [GOC:add, PMID:12952892]
comment: Note that this term is intended to cover the insertion of pro-apoptotic proteins such as Bax or its homologs into mitochondrial membranes which occurs as an early step in the apoptotic program.
synonym: "insertion of proteins into mitochondrial membranes during the induction of apoptosis" EXACT []
synonym: "protein insertion into mitochondrion membrane during induction of apoptosis" EXACT []
xref: Reactome:114264 "Translocation of activated BAX to the mitochondria"
xref: Reactome:139905 "Translocation of activated BAD protein to mitochondria"
xref: Reactome:139909 "Translocation of BMF to mitochondria"
xref: Reactome:139914 "Translocation of PUMA protein to mitochondria"
xref: Reactome:139919 "Translocation of BIM to mitochondria"
xref: Reactome:140216 "Translocation of NOXA to mitochondria"
xref: Reactome:447728 "Translocation of activated BAD protein to mitochondria"
xref: Reactome:447729 "Translocation of activated BAX to the mitochondria"
xref: Reactome:447734 "Translocation of BIM to mitochondria"
xref: Reactome:447736 "Translocation of BMF to mitochondria"
xref: Reactome:447802 "Translocation of PUMA protein to mitochondria"
xref: Reactome:468931 "Translocation of activated BAD protein to mitochondria"
xref: Reactome:468932 "Translocation of activated BAX to the mitochondria"
xref: Reactome:468937 "Translocation of BIM to mitochondria"
xref: Reactome:468939 "Translocation of BMF to mitochondria"
xref: Reactome:486760 "Translocation of BMF to mitochondria"
xref: Reactome:506579 "Translocation of activated BAD protein to mitochondria"
xref: Reactome:506581 "Translocation of activated BAX to the mitochondria"
is_a: GO:0008637 ! apoptotic mitochondrial changes
is_a: GO:0051204 ! protein insertion into mitochondrial membrane
relationship: part_of GO:0006917 ! induction of apoptosis

[Term]
id: GO:0001845
name: phagolysosome assembly
namespace: biological_process
def: "The process by which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "late phagosome biosynthesis" RELATED []
synonym: "late phagosome formation" RELATED []
synonym: "phagolysosome formation" RELATED [GOC:mah]
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0006909 ! phagocytosis
is_a: GO:0070925 ! organelle assembly

[Term]
id: GO:0001846
name: opsonin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that an opsonin is a blood serum protein or fragment which when deposited on the surface of a bacteria, virus, immune complex, or other particulate material acts a signal for phagocytosis to cells bearing the appropriate receptors. Not all complement components or fragments and not all antibodies have opsonic properties.
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001847
name: opsonin receptor activity
namespace: molecular_function
def: "Combining with an opsonin to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0001848
name: complement binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any component or product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways.
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001849
name: complement component C1q binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C1q component of the classical complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001850
name: complement component C3a binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C3a product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001851
name: complement component C3b binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C3b product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001852
name: complement component iC3b binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the iC3b product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001853
name: complement component C3dg binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C3dg product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001854
name: complement component C3d binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C3d product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001855
name: complement component C4b binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C4b product of the classical complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001846 ! opsonin binding
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001856
name: complement component C5a binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the C5a product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001848 ! complement binding

[Term]
id: GO:0001857
name: complement component C1q receptor activity
namespace: molecular_function
def: "Combining with the C1q component of the classical complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0001849 ! complement component C1q binding
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0001858
name: complement component iC3b receptor activity
namespace: molecular_function
def: "Combining with the iC3b product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0001852 ! complement component iC3b binding
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0001859
name: complement component C3dg receptor activity
namespace: molecular_function
def: "Combining with the C3dg product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0001860
name: complement component C3d receptor activity
namespace: molecular_function
def: "Combining with the C3d product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0001861
name: complement component C4b receptor activity
namespace: molecular_function
def: "Combining with the C4b product of the classical complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0001855 ! complement component C4b binding
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0001862
name: collectin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that collectins include such proteins as mannose-binding lectins (MBL) and surfactant proteins A and D (SP-A and SP-D).
is_a: GO:0001846 ! opsonin binding

[Term]
id: GO:0001863
name: collectin receptor activity
namespace: molecular_function
def: "Combining with a collectin to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that collectins include such proteins as mannose-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D).
is_a: GO:0001847 ! opsonin receptor activity

[Term]
id: GO:0001864
name: pentraxin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP).
is_a: GO:0001846 ! opsonin binding

[Term]
id: GO:0001865
name: NK T cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a NK T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:10704459]
comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments.
synonym: "natural killer T cell differentiation" EXACT []
synonym: "natural T cell differentiation" EXACT []
synonym: "NK T lymphocyte differentiation" EXACT []
synonym: "NK T-cell differentiation" EXACT []
synonym: "NK T-lymphocyte differentiation" EXACT []
synonym: "NKT cell differentiation" EXACT []
synonym: "NT cell differentiation" EXACT []
is_a: GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0001866
name: NK T cell proliferation
namespace: biological_process
def: "The expansion of a NK T cell population by cell division." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:10704459]
comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments.
synonym: "natural killer T cell proliferation" EXACT []
synonym: "natural T cell proliferation" EXACT []
synonym: "NK T lymphocyte proliferation" EXACT []
synonym: "NK T-cell proliferation" EXACT []
synonym: "NK T-lymphocyte proliferation" EXACT []
synonym: "NKT cell proliferation" EXACT []
synonym: "NT cell proliferation" EXACT []
is_a: GO:0046633 ! alpha-beta T cell proliferation

[Term]
id: GO:0001867
name: complement activation, lectin pathway
namespace: biological_process
def: "Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway.
xref: Reactome:166662 "Lectin pathway of complement activation"
xref: Reactome:448709 "Lectin pathway of complement activation"
xref: Reactome:469831 "Lectin pathway of complement activation"
xref: Reactome:487524 "Lectin pathway of complement activation"
is_a: GO:0006956 ! complement activation
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0001868
name: regulation of complement activation, lectin pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0030449 ! regulation of complement activation
is_a: GO:0045088 ! regulation of innate immune response
relationship: regulates GO:0001867 ! complement activation, lectin pathway

[Term]
id: GO:0001869
name: negative regulation of complement activation, lectin pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of complement activation, lectin pathway" EXACT []
synonym: "down-regulation of complement activation, lectin pathway" EXACT []
synonym: "downregulation of complement activation, lectin pathway" EXACT []
synonym: "inhibition of complement activation, lectin pathway" NARROW []
is_a: GO:0001868 ! regulation of complement activation, lectin pathway
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0045916 ! negative regulation of complement activation
relationship: negatively_regulates GO:0001867 ! complement activation, lectin pathway

[Term]
id: GO:0001870
name: positive regulation of complement activation, lectin pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of complement activation, lectin pathway" NARROW []
synonym: "stimulation of complement activation, lectin pathway" NARROW []
synonym: "up regulation of complement activation, lectin pathway" EXACT []
synonym: "up-regulation of complement activation, lectin pathway" EXACT []
synonym: "upregulation of complement activation, lectin pathway" EXACT []
is_a: GO:0001868 ! regulation of complement activation, lectin pathway
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0045917 ! positive regulation of complement activation
relationship: positively_regulates GO:0001867 ! complement activation, lectin pathway

[Term]
id: GO:0001871
name: pattern binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan." [PMID:12072369, PMID:12225919, PMID:12507420, PMID:12925128, PMID:14523544]
comment: Note that this term and its child terms are intended for annotation of gene products which function to recognize (bind) the repeating structural units such as polysaccharides or peptidoglycans commonly found in microbial cell walls and virions. If such binding is coupled to signal transduction, use 'pattern recognition receptor activity ; GO:0008329' instead.
subset: goslim_pir
subset: gosubset_prok
synonym: "pattern recognition activity" BROAD []
is_a: GO:0005488 ! binding

[Term]
id: GO:0001872
name: zymosan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with zymosan." [PMID:14707091]
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0001873
name: polysaccharide receptor activity
namespace: molecular_function
def: "Combining with a polysaccharide to initiate a change in cell activity." [PMID:14707091]
is_a: GO:0008329 ! pattern recognition receptor activity
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0001874
name: zymosan receptor activity
namespace: molecular_function
def: "Combining with zymosan to initiate a change in cell activity." [PMID:14707091]
is_a: GO:0001872 ! zymosan binding
is_a: GO:0001873 ! polysaccharide receptor activity

[Term]
id: GO:0001875
name: lipopolysaccharide receptor activity
namespace: molecular_function
def: "Combining with lipopolysaccharide to initiate a change in cell activity." [PMID:14609719]
synonym: "endotoxin receptor activity" BROAD []
synonym: "LPS receptor activity" EXACT []
is_a: GO:0001530 ! lipopolysaccharide binding
is_a: GO:0008329 ! pattern recognition receptor activity

[Term]
id: GO:0001876
name: lipoarabinomannan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lipoarabinomannan." [PMID:10586073]
synonym: "LAM binding" EXACT []
is_a: GO:0001871 ! pattern binding

[Term]
id: GO:0001877
name: lipoarabinomannan receptor activity
namespace: molecular_function
def: "Combining with lipoarabinomannan to initiate a change in cell activity." [PMID:10586073]
synonym: "LAM receptor activity" EXACT []
is_a: GO:0001876 ! lipoarabinomannan binding
is_a: GO:0008329 ! pattern recognition receptor activity

[Term]
id: GO:0001878
name: response to yeast
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species." [PMID:14707091]
is_a: GO:0009620 ! response to fungus

[Term]
id: GO:0001879
name: detection of yeast
namespace: biological_process
def: "The series of events in which a stimulus from a yeast is received and converted into a molecular signal." [PMID:14707091]
is_a: GO:0001878 ! response to yeast
is_a: GO:0016046 ! detection of fungus

[Term]
id: GO:0001880
name: Mullerian duct regression
namespace: biological_process
def: "The process by which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos." [GOC:dph, PMID:12368913]
is_a: GO:0060033 ! anatomical structure regression
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0001881
name: receptor recycling
namespace: biological_process
def: "The process by which receptor molecules are returned to an active state and in an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GOC:dph]
is_a: GO:0023046 ! signaling process
is_a: GO:0043112 ! receptor metabolic process

[Term]
id: GO:0001882
name: nucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0001883
name: purine nucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose." [GOC:hjd]
is_a: GO:0001882 ! nucleoside binding

[Term]
id: GO:0001884
name: pyrimidine nucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose." [GOC:hjd]
is_a: GO:0001882 ! nucleoside binding

[Term]
id: GO:0001885
name: endothelial cell development
namespace: biological_process
def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0001886
name: endothelial cell morphogenesis
namespace: biological_process
def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003382 ! epithelial cell morphogenesis
relationship: part_of GO:0001885 ! endothelial cell development

[Term]
id: GO:0001887
name: selenium metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the nonmetallic element selenium or compounds that contain selenium, such as selenocysteine." [PMID:12730456]
subset: gosubset_prok
synonym: "selenium metabolism" EXACT []
is_a: GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0001888
name: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan." [EC:2.4.1.223]
synonym: "alpha-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223]
synonym: "alpha-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.223]
synonym: "alpha1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223]
synonym: "glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.223]
xref: EC:2.4.1.223
xref: MetaCyc:2.4.1.223-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0001889
name: liver development
namespace: biological_process
def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary"]
is_a: GO:0048513 ! organ development
relationship: part_of GO:0061008 ! hepaticobiliary system development

[Term]
id: GO:0001890
name: placenta development
namespace: biological_process
def: "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary"]
synonym: "placental development" EXACT []
synonym: "placentation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048513 ! organ development

[Term]
id: GO:0001891
name: phagocytic cup
namespace: cellular_component
def: "An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome." [PMID:10358769]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0001892
name: embryonic placenta development
namespace: biological_process
def: "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary"]
synonym: "fetal placenta development" EXACT [GOC:dph]
is_a: GO:0048568 ! embryonic organ development
relationship: part_of GO:0001701 ! in utero embryonic development
relationship: part_of GO:0001890 ! placenta development

[Term]
id: GO:0001893
name: maternal placenta development
namespace: biological_process
def: "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary"]
synonym: "decidua development" RELATED [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001890 ! placenta development

[Term]
id: GO:0001894
name: tissue homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal equilibrium within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete]
synonym: "tissue maintenance" NARROW [GOC:add]
is_a: GO:0060249 ! anatomical structure homeostasis
relationship: part_of GO:0048871 ! multicellular organismal homeostasis

[Term]
id: GO:0001895
name: retina homeostasis
namespace: biological_process
def: "A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178]
is_a: GO:0001894 ! tissue homeostasis

[Term]
id: GO:0001896
name: autolysis
namespace: biological_process
def: "The spontaneous death by lysis of bacteria in response to environmental conditions." [GOC:add]
subset: gosubset_prok
xref: Wikipedia:Autolysis
is_a: GO:0019835 ! cytolysis

[Term]
id: GO:0001897
name: cytolysis by symbiont of host cells
namespace: biological_process
def: "The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
synonym: "cytolysis by organism of host cells" EXACT []
is_a: GO:0001907 ! killing by symbiont of host cells
is_a: GO:0051801 ! cytolysis of cells in other organism during symbiotic interaction
is_a: GO:0052025 ! modification by symbiont of host cell membrane

[Term]
id: GO:0001898
name: regulation of cytolysis by symbiont of host cells
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051802 ! regulation of cytolysis of cells in other organism during symbiotic interaction
relationship: regulates GO:0001897 ! cytolysis by symbiont of host cells

[Term]
id: GO:0001899
name: negative regulation of cytolysis by symbiont of host cells
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "down regulation by symbiont of cytolysis of host cells" EXACT []
synonym: "down-regulation by symbiont of cytolysis of host cells" EXACT []
synonym: "downregulation by symbiont of cytolysis of host cells" EXACT []
synonym: "inhibition by symbiont of cytolysis of host cells" NARROW []
synonym: "negative regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells
is_a: GO:0051803 ! negative regulation of cytolysis of cells in other organism during symbiotic interaction
relationship: negatively_regulates GO:0001897 ! cytolysis by symbiont of host cells

[Term]
id: GO:0001900
name: positive regulation of cytolysis by symbiont of host cells
namespace: biological_process
def: "Any process by which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "activation by symbiont of cytolysis of host cells" NARROW []
synonym: "positive regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation by symbiont of cytolysis of host cells" NARROW []
synonym: "up regulation by symbiont of cytolysis of host cells" EXACT []
synonym: "up-regulation by symbiont of cytolysis of host cells" EXACT []
synonym: "upregulation by symbiont of cytolysis of host cells" EXACT []
is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells
is_a: GO:0051804 ! positive regulation of cytolysis of cells in other organism during symbiotic interaction
relationship: positively_regulates GO:0001897 ! cytolysis by symbiont of host cells

[Term]
id: GO:0001905
name: activation of membrane attack complex
namespace: biological_process
def: "The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of MAC" EXACT []
synonym: "activation of TCC" NARROW []
synonym: "activation of terminal complement complex" NARROW [GOC:add]
synonym: "activation of the terminal complement cascade" NARROW []
synonym: "MAC assembly" EXACT [GOC:rl]
synonym: "MAC formation" EXACT [GOC:rl]
synonym: "membrane attack complex assembly" EXACT [GOC:rl]
synonym: "membrane attack complex formation" EXACT [GOC:rl]
is_a: GO:0006956 ! complement activation

[Term]
id: GO:0001906
name: cell killing
namespace: biological_process
def: "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add]
subset: goslim_pir
subset: gosubset_prok
synonym: "necrosis" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0001907
name: killing by symbiont of host cells
namespace: biological_process
def: "Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
is_a: GO:0044004 ! disruption by symbiont of host cells
is_a: GO:0051883 ! killing of cells in other organism during symbiotic interaction

[Term]
id: GO:0001909
name: leukocyte mediated cytotoxicity
namespace: biological_process
def: "The directed killing of a target cell by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology", PMID:11911826]
comment: This term was improved by GO_REF:0000022. It was moved. Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system.
synonym: "immune cell mediated cell death" EXACT []
synonym: "immune cell mediated cell killing" EXACT []
synonym: "immune cell mediated cytotoxicity" EXACT []
synonym: "leucocyte mediated cytotoxicity" EXACT []
is_a: GO:0001906 ! cell killing
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0001910
name: regulation of leukocyte mediated cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11911826]
synonym: "regulation of immune cell mediated cell death" EXACT []
synonym: "regulation of immune cell mediated cell killing" EXACT []
synonym: "regulation of immune cell mediated cytotoxicity" EXACT []
synonym: "regulation of leucocyte mediated cytotoxicity" EXACT []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0031341 ! regulation of cell killing
relationship: regulates GO:0001909 ! leukocyte mediated cytotoxicity

[Term]
id: GO:0001911
name: negative regulation of leukocyte mediated cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11911826]
synonym: "down regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "down-regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "downregulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "inhibition of leukocyte mediated cytotoxicity" NARROW []
synonym: "negative regulation of immune cell mediated cytotoxicity" EXACT []
synonym: "negative regulation of leucocyte mediated cytotoxicity" EXACT []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0031342 ! negative regulation of cell killing
relationship: negatively_regulates GO:0001909 ! leukocyte mediated cytotoxicity

[Term]
id: GO:0001912
name: positive regulation of leukocyte mediated cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11911826]
synonym: "activation of leukocyte mediated cytotoxicity" NARROW []
synonym: "positive regulation of immune cell mediated cytotoxicity" EXACT []
synonym: "positive regulation of leucocyte mediated cytotoxicity" EXACT []
synonym: "stimulation of leukocyte mediated cytotoxicity" NARROW []
synonym: "up regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "up-regulation of leukocyte mediated cytotoxicity" EXACT []
synonym: "upregulation of leukocyte mediated cytotoxicity" EXACT []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0031343 ! positive regulation of cell killing
relationship: positively_regulates GO:0001909 ! leukocyte mediated cytotoxicity

[Term]
id: GO:0001913
name: T cell mediated cytotoxicity
namespace: biological_process
def: "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11911826]
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not.
synonym: "T cell mediated apoptosis" EXACT []
synonym: "T cell mediated cell death" EXACT []
synonym: "T cell mediated cell killing" EXACT []
synonym: "T cell mediated cytolysis" RELATED []
synonym: "T lymphocyte mediated cytotoxicity" EXACT []
synonym: "T-cell mediated apoptosis" EXACT []
synonym: "T-cell mediated cell death" EXACT []
synonym: "T-cell mediated cell killing" EXACT []
synonym: "T-cell mediated cytotoxicity" EXACT []
synonym: "T-lymphocyte mediated cytotoxicity" EXACT []
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0002456 ! T cell mediated immunity
is_a: GO:0006917 ! induction of apoptosis

[Term]
id: GO:0001914
name: regulation of T cell mediated cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "regulation of T cell mediated apoptosis" EXACT []
synonym: "regulation of T cell mediated cell death" EXACT []
synonym: "regulation of T cell mediated cell killing" EXACT []
synonym: "regulation of T cell mediated cytolysis" RELATED []
synonym: "regulation of T lymphocyte mediated cytotoxicity" EXACT []
synonym: "regulation of T-cell mediated apoptosis" EXACT []
synonym: "regulation of T-cell mediated cell death" EXACT []
synonym: "regulation of T-cell mediated cell killing" EXACT []
synonym: "regulation of T-cell mediated cytolysis" RELATED []
synonym: "regulation of T-cell mediated cytotoxicity" EXACT []
synonym: "regulation of T-lymphocyte mediated cytotoxicity" EXACT []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002709 ! regulation of T cell mediated immunity
relationship: regulates GO:0001913 ! T cell mediated cytotoxicity

[Term]
id: GO:0001915
name: negative regulation of T cell mediated cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of T cell mediated cytotoxicity" EXACT []
synonym: "down-regulation of T cell mediated cytotoxicity" EXACT []
synonym: "downregulation of T cell mediated cytotoxicity" EXACT []
synonym: "inhibition of T cell mediated cytotoxicity" NARROW []
synonym: "negative regulation of T cell mediated apoptosis" EXACT []
synonym: "negative regulation of T cell mediated cell death" EXACT []
synonym: "negative regulation of T cell mediated cell killing" EXACT []
synonym: "negative regulation of T cell mediated cytolysis" RELATED []
synonym: "negative regulation of T lymphocyte mediated cytotoxicity" EXACT []
synonym: "negative regulation of T-cell mediated apoptosis" EXACT []
synonym: "negative regulation of T-cell mediated cell death" EXACT []
synonym: "negative regulation of T-cell mediated cell killing" EXACT []
synonym: "negative regulation of T-cell mediated cytolysis" RELATED []
synonym: "negative regulation of T-cell mediated cytotoxicity" EXACT []
synonym: "negative regulation of T-lymphocyte mediated cytotoxicity" EXACT []
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
relationship: negatively_regulates GO:0001913 ! T cell mediated cytotoxicity

[Term]
id: GO:0001916
name: positive regulation of T cell mediated cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of T cell mediated cytotoxicity" NARROW []
synonym: "positive regulation of T cell mediated apoptosis" EXACT []
synonym: "positive regulation of T cell mediated cell death" EXACT []
synonym: "positive regulation of T cell mediated cell killing" EXACT []
synonym: "positive regulation of T cell mediated cytolysis" RELATED []
synonym: "positive regulation of T lymphocyte mediated cytotoxicity" EXACT []
synonym: "positive regulation of T-cell mediated apoptosis" EXACT []
synonym: "positive regulation of T-cell mediated cell death" EXACT []
synonym: "positive regulation of T-cell mediated cell killing" EXACT []
synonym: "positive regulation of T-cell mediated cytolysis" RELATED []
synonym: "positive regulation of T-cell mediated cytotoxicity" EXACT []
synonym: "positive regulation of T-lymphocyte mediated cytotoxicity" EXACT []
synonym: "stimulation of T cell mediated cytotoxicity" NARROW []
synonym: "up regulation of T cell mediated cytotoxicity" EXACT []
synonym: "up-regulation of T cell mediated cytotoxicity" EXACT []
synonym: "upregulation of T cell mediated cytotoxicity" EXACT []
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
relationship: positively_regulates GO:0001913 ! T cell mediated cytotoxicity

[Term]
id: GO:0001917
name: photoreceptor inner segment
namespace: cellular_component
def: "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:add, PMID:12019563]
subset: goslim_pir
is_a: GO:0044464 ! cell part

[Term]
id: GO:0001918
name: farnesylated protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a farnesylated protein." [GOC:add, PMID:14555765]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001919
name: regulation of receptor recycling
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0001881 ! receptor recycling

[Term]
id: GO:0001920
name: negative regulation of receptor recycling
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of receptor recycling." [GOC:add]
synonym: "down regulation of receptor recycling" EXACT []
synonym: "down-regulation of receptor recycling" EXACT []
synonym: "downregulation of receptor recycling" EXACT []
synonym: "inhibition of receptor recycling" NARROW []
is_a: GO:0001919 ! regulation of receptor recycling
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
relationship: negatively_regulates GO:0001881 ! receptor recycling

[Term]
id: GO:0001921
name: positive regulation of receptor recycling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor recycling." [GOC:add]
synonym: "activation of receptor recycling" NARROW []
synonym: "stimulation of receptor recycling" NARROW []
synonym: "up regulation of receptor recycling" EXACT []
synonym: "up-regulation of receptor recycling" EXACT []
synonym: "upregulation of receptor recycling" EXACT []
is_a: GO:0001919 ! regulation of receptor recycling
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
relationship: positively_regulates GO:0001881 ! receptor recycling

[Term]
id: GO:0001922
name: B-1 B cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus.
synonym: "B-1 B lymphocyte homeostasis" EXACT []
synonym: "B-1 B-cell homeostasis" EXACT []
synonym: "B-1 B-lymphocyte homeostasis" EXACT []
is_a: GO:0001782 ! B cell homeostasis

[Term]
id: GO:0001923
name: B-1 B cell differentiation
namespace: biological_process
def: "The process whereby a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "B-1 B lymphocyte differentiation" EXACT []
synonym: "B-1 B-cell differentiation" EXACT []
synonym: "B-1 B-lymphocyte differentiation" EXACT []
is_a: GO:0002335 ! mature B cell differentiation

[Term]
id: GO:0001924
name: regulation of B-1 B cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "regulation of B-1 B lymphocyte differentiation" EXACT []
synonym: "regulation of B-1 B-cell differentiation" EXACT []
synonym: "regulation of B-1 B-lymphocyte differentiation" EXACT []
is_a: GO:0045577 ! regulation of B cell differentiation
relationship: regulates GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0001925
name: negative regulation of B-1 B cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of B-1 B cell differentiation" EXACT []
synonym: "down-regulation of B-1 B cell differentiation" EXACT []
synonym: "downregulation of B-1 B cell differentiation" EXACT []
synonym: "inhibition of B-1 B cell differentiation" NARROW []
synonym: "negative regulation of B-1 B lymphocyte differentiation" EXACT []
synonym: "negative regulation of B-1 B-cell differentiation" EXACT []
synonym: "negative regulation of B-1 B-lymphocyte differentiation" EXACT []
is_a: GO:0001924 ! regulation of B-1 B cell differentiation
is_a: GO:0045578 ! negative regulation of B cell differentiation
relationship: negatively_regulates GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0001926
name: positive regulation of B-1 B cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of B-1 B cell differentiation" NARROW []
synonym: "positive regulation of B-1 B lymphocyte differentiation" EXACT []
synonym: "positive regulation of B-1 B-cell differentiation" EXACT []
synonym: "positive regulation of B-1 B-lymphocyte differentiation" EXACT []
synonym: "stimulation of B-1 B cell differentiation" NARROW []
synonym: "up regulation of B-1 B cell differentiation" EXACT []
synonym: "up-regulation of B-1 B cell differentiation" EXACT []
synonym: "upregulation of B-1 B cell differentiation" EXACT []
is_a: GO:0001924 ! regulation of B-1 B cell differentiation
is_a: GO:0045579 ! positive regulation of B cell differentiation
relationship: positively_regulates GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0001927
name: exocyst assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex." [GOC:hjd, Wikipedia:Exocyst]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0006904 ! vesicle docking during exocytosis

[Term]
id: GO:0001928
name: regulation of exocyst assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exocyst assembly." [GOC:hjd]
comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families.
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:0043254 ! regulation of protein complex assembly
relationship: regulates GO:0001927 ! exocyst assembly

[Term]
id: GO:0001929
name: negative regulation of exocyst assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of exocyst assembly." [GOC:hjd]
synonym: "down regulation of exocyst assembly" EXACT []
synonym: "down-regulation of exocyst assembly" EXACT []
synonym: "downregulation of exocyst assembly" EXACT []
synonym: "inhibition of exocyst assembly" NARROW []
is_a: GO:0001928 ! regulation of exocyst assembly
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0001927 ! exocyst assembly

[Term]
id: GO:0001930
name: positive regulation of exocyst assembly
namespace: biological_process
def: "Any process that increases the rate or extent of exocyst assembly." [GOC:hjd]
synonym: "activation of exocyst assembly" NARROW []
synonym: "stimulation of exocyst assembly" NARROW []
synonym: "up regulation of exocyst assembly" EXACT []
synonym: "up-regulation of exocyst assembly" EXACT []
synonym: "upregulation of exocyst assembly" EXACT []
is_a: GO:0001928 ! regulation of exocyst assembly
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0001927 ! exocyst assembly

[Term]
id: GO:0001931
name: uropod
namespace: cellular_component
def: "A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12714569, PMID:12787750]
synonym: "distal pole complex" RELATED []
synonym: "retractile pole" RELATED []
synonym: "uropodium" EXACT []
is_a: GO:0042995 ! cell projection
relationship: part_of GO:0031254 ! trailing edge

[Term]
id: GO:0001932
name: regulation of protein amino acid phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]
subset: gosubset_prok
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0042325 ! regulation of phosphorylation
relationship: regulates GO:0006468 ! protein amino acid phosphorylation

[Term]
id: GO:0001933
name: negative regulation of protein amino acid phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
subset: gosubset_prok
synonym: "down regulation of protein amino acid phosphorylation" EXACT []
synonym: "down-regulation of protein amino acid phosphorylation" EXACT []
synonym: "downregulation of protein amino acid phosphorylation" EXACT []
synonym: "inhibition of protein amino acid phosphorylation" NARROW []
is_a: GO:0001932 ! regulation of protein amino acid phosphorylation
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0042326 ! negative regulation of phosphorylation
relationship: negatively_regulates GO:0006468 ! protein amino acid phosphorylation

[Term]
id: GO:0001934
name: positive regulation of protein amino acid phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]
subset: gosubset_prok
synonym: "activation of protein amino acid phosphorylation" NARROW []
synonym: "stimulation of protein amino acid phosphorylation" NARROW []
synonym: "up regulation of protein amino acid phosphorylation" EXACT []
synonym: "up-regulation of protein amino acid phosphorylation" EXACT []
synonym: "upregulation of protein amino acid phosphorylation" EXACT []
is_a: GO:0001932 ! regulation of protein amino acid phosphorylation
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0042327 ! positive regulation of phosphorylation
relationship: positively_regulates GO:0006468 ! protein amino acid phosphorylation

[Term]
id: GO:0001935
name: endothelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0001936
name: regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add]
is_a: GO:0042127 ! regulation of cell proliferation
relationship: regulates GO:0001935 ! endothelial cell proliferation

[Term]
id: GO:0001937
name: negative regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add]
synonym: "down regulation of endothelial cell proliferation" EXACT []
synonym: "down-regulation of endothelial cell proliferation" EXACT []
synonym: "downregulation of endothelial cell proliferation" EXACT []
synonym: "inhibition of endothelial cell proliferation" NARROW []
is_a: GO:0001936 ! regulation of endothelial cell proliferation
is_a: GO:0008285 ! negative regulation of cell proliferation
relationship: negatively_regulates GO:0001935 ! endothelial cell proliferation

[Term]
id: GO:0001938
name: positive regulation of endothelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add]
synonym: "activation of endothelial cell proliferation" NARROW []
synonym: "stimulation of endothelial cell proliferation" NARROW []
synonym: "up regulation of endothelial cell proliferation" EXACT []
synonym: "up-regulation of endothelial cell proliferation" EXACT []
synonym: "upregulation of endothelial cell proliferation" EXACT []
is_a: GO:0001936 ! regulation of endothelial cell proliferation
is_a: GO:0008284 ! positive regulation of cell proliferation
relationship: positively_regulates GO:0001935 ! endothelial cell proliferation

[Term]
id: GO:0001939
name: female pronucleus
namespace: cellular_component
def: "The pronucleus originating from the ovum that is being fertilized." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0045120 ! pronucleus

[Term]
id: GO:0001940
name: male pronucleus
namespace: cellular_component
def: "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0045120 ! pronucleus

[Term]
id: GO:0001941
name: postsynaptic membrane organization
namespace: biological_process
def: "The maintenance of membrane composition in a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph]
synonym: "postsynaptic membrane organisation" EXACT [GOC:curators]
is_a: GO:0016044 ! cellular membrane organization

[Term]
id: GO:0001942
name: hair follicle development
namespace: biological_process
alt_id: GO:0001943
def: "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open." [GOC:dph, http://cancerweb.ncl.ac.uk]
is_a: GO:0008544 ! epidermis development
is_a: GO:0022405 ! hair cycle process

[Term]
id: GO:0001944
name: vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0048513 ! organ development

[Term]
id: GO:0001945
name: lymph vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lymphatic vasculature over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001944 ! vasculature development

[Term]
id: GO:0001946
name: lymphangiogenesis
namespace: biological_process
def: "Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels." [GOC:dph, PMID:11596157]
synonym: "lymph vessel formation" EXACT systematic_synonym []
xref: Wikipedia:Lymphangiogenesis
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0001945 ! lymph vessel development

[Term]
id: GO:0001947
name: heart looping
namespace: biological_process
def: "The characteristic morphogenetic movements where the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration." [GOC:dph, PMID:12094232]
synonym: "cardiac looping" EXACT []
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0001948
name: glycoprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001949
name: sebaceous gland cell differentiation
namespace: biological_process
def: "Process whereby a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell." [GOC:mgi_curators, PMID:15737203]
synonym: "sebocytes differentiation" NARROW [GOC:mgi_curators]
is_a: GO:0009913 ! epidermal cell differentiation
relationship: part_of GO:0048733 ! sebaceous gland development

[Term]
id: GO:0001950
name: plasma membrane enriched fraction
namespace: cellular_component
def: "The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes." [GOC:mgi_curators, PMID:11562363, PMID:15601832]
synonym: "PME fraction" RELATED [GOC:mah]
is_a: GO:0000267 ! cell fraction
relationship: part_of GO:0005624 ! membrane fraction

[Term]
id: GO:0001951
name: intestinal D-glucose absorption
namespace: biological_process
def: "Uptake of D-glucose into the blood by absorption from the small intestine." [GOC:mgi_curators, PMID:5601832]
is_a: GO:0015758 ! glucose transport
is_a: GO:0050892 ! intestinal absorption

[Term]
id: GO:0001952
name: regulation of cell-matrix adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd]
is_a: GO:0010810 ! regulation of cell-substrate adhesion
relationship: regulates GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0001953
name: negative regulation of cell-matrix adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of cell adhesion to the extracellular matrix." [GOC:hjd]
synonym: "down regulation of cell-matrix adhesion" EXACT []
synonym: "down-regulation of cell-matrix adhesion" EXACT []
synonym: "downregulation of cell-matrix adhesion" EXACT []
synonym: "inhibition of cell-matrix adhesion" NARROW []
is_a: GO:0001952 ! regulation of cell-matrix adhesion
is_a: GO:0010812 ! negative regulation of cell-substrate adhesion
relationship: negatively_regulates GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0001954
name: positive regulation of cell-matrix adhesion
namespace: biological_process
def: "Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix." [GOC:hjd]
synonym: "activation of cell-matrix adhesion" NARROW []
synonym: "stimulation of cell-matrix adhesion" NARROW []
synonym: "up regulation of cell-matrix adhesion" EXACT []
synonym: "up-regulation of cell-matrix adhesion" EXACT []
synonym: "upregulation of cell-matrix adhesion" EXACT []
is_a: GO:0001952 ! regulation of cell-matrix adhesion
is_a: GO:0010811 ! positive regulation of cell-substrate adhesion
relationship: positively_regulates GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0001955
name: blood vessel maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph]
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0001568 ! blood vessel development

[Term]
id: GO:0001956
name: positive regulation of neurotransmitter secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd]
synonym: "activation of neurotransmitter secretion" NARROW []
synonym: "stimulation of neurotransmitter secretion" NARROW []
synonym: "up regulation of neurotransmitter secretion" EXACT []
synonym: "up-regulation of neurotransmitter secretion" EXACT []
synonym: "upregulation of neurotransmitter secretion" EXACT []
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051590 ! positive regulation of neurotransmitter transport
relationship: positively_regulates GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0001957
name: intramembranous ossification
namespace: biological_process
def: "The formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified. Intramembranous ossification is the way flat bones and the shell of a turtle are formed." [ISBN:0878932437]
xref: Wikipedia:Intramembranous_ossification
is_a: GO:0001503 ! ossification

[Term]
id: GO:0001958
name: endochondral ossification
namespace: biological_process
def: "The formation of bone by the replacement of cartilage tissue with mineralized bone." [ISBN:0878932437]
xref: Wikipedia:Endochondral_ossification
is_a: GO:0001503 ! ossification
relationship: part_of GO:0060350 ! endochondral bone morphogenesis

[Term]
id: GO:0001959
name: regulation of cytokine-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]
synonym: "regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of cytokine mediated signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0001960
name: negative regulation of cytokine-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]
synonym: "down regulation of cytokine mediated signaling pathway" EXACT []
synonym: "down-regulation of cytokine mediated signaling pathway" EXACT []
synonym: "downregulation of cytokine mediated signaling pathway" EXACT []
synonym: "inhibition of cytokine mediated signaling pathway" NARROW []
synonym: "negative regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "negative regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of cytokine mediated signalling pathway" EXACT []
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
relationship: negatively_regulates GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0001961
name: positive regulation of cytokine-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd]
synonym: "activation of cytokine mediated signaling pathway" NARROW []
synonym: "positive regulation of cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "positive regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of cytokine mediated signalling pathway" EXACT []
synonym: "stimulation of cytokine mediated signaling pathway" NARROW []
synonym: "up regulation of cytokine mediated signaling pathway" EXACT []
synonym: "up-regulation of cytokine mediated signaling pathway" EXACT []
synonym: "upregulation of cytokine mediated signaling pathway" EXACT []
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
relationship: positively_regulates GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0001962
name: alpha-1,3-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,3-linkage." [GOC:hjd, PMID:10854427]
synonym: "isoglobotriaosylceramide synthase" NARROW []
xref: EC:2.4.1.-
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0001963
name: synaptic transmission, dopaminergic
namespace: biological_process
def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:dph]
is_a: GO:0007270 ! nerve-nerve synaptic transmission

[Term]
id: GO:0001964
name: startle response
namespace: biological_process
def: "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph]
xref: Wikipedia:Startle_reaction
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0050905 ! neuromuscular process

[Term]
id: GO:0001965
name: G-protein alpha-subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd]
synonym: "G-alpha protein subunit binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001966
name: thigmotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to touch." [GOC:dph]
synonym: "stereotaxis" EXACT []
synonym: "taxis in response to mechanical stimulus" BROAD []
synonym: "taxis in response to touch stimulus" EXACT []
is_a: GO:0042330 ! taxis

[Term]
id: GO:0001967
name: suckling behavior
namespace: biological_process
def: "Specific actions of a newborn or infant mammal that result in the derivation of nourishment from the breast." [GOC:dph]
synonym: "nursing behavior" EXACT []
is_a: GO:0007631 ! feeding behavior
is_a: GO:0051705 ! behavioral interaction between organisms

[Term]
id: GO:0001968
name: fibronectin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids." [GOC:hjd]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0001969
name: regulation of activation of membrane attack complex
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd]
synonym: "regulation of activation of MAC" EXACT [GOC:mah]
synonym: "regulation of activation of TCC" NARROW [GOC:mah]
synonym: "regulation of activation of terminal complement complex" NARROW [GOC:add]
synonym: "regulation of activation of the terminal complement cascade" NARROW [GOC:mah]
synonym: "regulation of MAC assembly" EXACT [GOC:rl]
synonym: "regulation of MAC formation" EXACT [GOC:rl]
synonym: "regulation of membrane attack complex assembly" EXACT [GOC:rl]
synonym: "regulation of membrane attack complex formation" EXACT [GOC:rl]
is_a: GO:0030449 ! regulation of complement activation
relationship: regulates GO:0001905 ! activation of membrane attack complex

[Term]
id: GO:0001970
name: positive regulation of activation of membrane attack complex
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd]
synonym: "activation of activation of membrane attack complex" NARROW []
synonym: "positive regulation of activation of MAC" EXACT [GOC:mah]
synonym: "positive regulation of activation of TCC" NARROW [GOC:mah]
synonym: "positive regulation of activation of terminal complement complex" NARROW [GOC:add]
synonym: "positive regulation of activation of the terminal complement cascade" NARROW [GOC:mah]
synonym: "positive regulation of MAC assembly" EXACT [GOC:rl]
synonym: "positive regulation of MAC formation" EXACT [GOC:rl]
synonym: "positive regulation of membrane attack complex assembly" EXACT [GOC:rl]
synonym: "positive regulation of membrane attack complex formation" EXACT [GOC:rl]
synonym: "stimulation of activation of membrane attack complex" NARROW []
synonym: "up regulation of activation of membrane attack complex" EXACT []
synonym: "up-regulation of activation of membrane attack complex" EXACT []
synonym: "upregulation of activation of membrane attack complex" EXACT []
is_a: GO:0001969 ! regulation of activation of membrane attack complex
is_a: GO:0045917 ! positive regulation of complement activation
relationship: positively_regulates GO:0001905 ! activation of membrane attack complex

[Term]
id: GO:0001971
name: negative regulation of activation of membrane attack complex
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd]
synonym: "down regulation of activation of membrane attack complex" EXACT []
synonym: "down-regulation of activation of membrane attack complex" EXACT []
synonym: "downregulation of activation of membrane attack complex" EXACT []
synonym: "inhibition of activation of membrane attack complex" NARROW []
synonym: "negative regulation of activation of MAC" EXACT [GOC:mah]
synonym: "negative regulation of activation of TCC" NARROW [GOC:mah]
synonym: "negative regulation of activation of terminal complement complex" NARROW [GOC:add]
synonym: "negative regulation of activation of the terminal complement cascade" NARROW [GOC:mah]
synonym: "negative regulation of MAC assembly" EXACT [GOC:rl]
synonym: "negative regulation of MAC formation" EXACT [GOC:rl]
synonym: "negative regulation of membrane attack complex assembly" EXACT [GOC:rl]
synonym: "negative regulation of membrane attack complex formation" EXACT [GOC:rl]
is_a: GO:0001969 ! regulation of activation of membrane attack complex
is_a: GO:0045916 ! negative regulation of complement activation
relationship: negatively_regulates GO:0001905 ! activation of membrane attack complex

[Term]
id: GO:0001972
name: retinoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid." [GOC:hjd]
is_a: GO:0005501 ! retinoid binding
is_a: GO:0033293 ! monocarboxylic acid binding

[Term]
id: GO:0001973
name: adenosine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "adenosine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0001974
name: blood vessel remodeling
namespace: biological_process
def: "The reorganization or renovation of existing blood vessels." [GOC:hjd]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0048514 ! blood vessel morphogenesis

[Term]
id: GO:0001975
name: response to amphetamine
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [ChEBI:2679, GOC:dph, GOC:ef]
is_a: GO:0014075 ! response to amine stimulus

[Term]
id: GO:0001976
name: neurological system process involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The regulation of blood pressure mediated by detection of stimuli and a neurological response." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "blood pressure regulation by neurological process" EXACT []
synonym: "fast control of arterial pressure" RELATED []
synonym: "neurological process involved in regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0050877 ! neurological system process
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0001977
name: renal system process involved in regulation of blood volume
namespace: biological_process
def: "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "renal blood volume control of blood pressure" RELATED []
synonym: "renal regulation of blood volume" RELATED [GOC:dph, GOC:tb]
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0001978
name: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
namespace: biological_process
def: "The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "baroreceptor feedback control of blood pressure" RELATED []
synonym: "baroreceptor pressure buffer system" RELATED [ISBN:068340007X "Stedman's Medical Dictionary"]
synonym: "carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback

[Term]
id: GO:0001979
name: regulation of systemic arterial blood pressure by chemoreceptor signaling
namespace: biological_process
def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "chemoreceptor control of blood pressure" RELATED []
synonym: "chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of systemic arterial blood pressure by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0001980
name: regulation of systemic arterial blood pressure by ischemic conditions
namespace: biological_process
def: "The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "CNS ischemic response" RELATED [ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "ischemic control of blood pressure" RELATED []
synonym: "ischemic regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0001981
name: baroreceptor detection of arterial stretch
namespace: biological_process
def: "The series of events by which the change in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"]
is_a: GO:0003018 ! vascular process in circulatory system
is_a: GO:0050982 ! detection of mechanical stimulus
relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback

[Term]
id: GO:0001982
name: baroreceptor response to decreased systemic arterial blood pressure
namespace: biological_process
def: "The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels." [GOC:dph, GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology", ISBN:0721643949 "Textbook of Medical Physiology"]
is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure

[Term]
id: GO:0001983
name: baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def: "The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology", ISBN:0721643949 "Textbook of Medical Physiology"]
is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure

[Term]
id: GO:0001984
name: vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def: "An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"]
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure

[Term]
id: GO:0001985
name: negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "down regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
synonym: "down-regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
synonym: "downregulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
synonym: "inhibition of heart contraction rate in baroreceptor response to increased blood pressure" NARROW []
synonym: "negative control of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
synonym: "negative regulation of cardiac contraction rate in baroreceptor response to increased blood pressure" RELATED []
synonym: "negative regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT []
is_a: GO:0010459 ! negative regulation of heart rate
relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure

[Term]
id: GO:0001986
name: negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def: "Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure" EXACT []
synonym: "decreased strength of cardiac contraction during baroreceptor response to increased blood pressure" EXACT []
is_a: GO:0045822 ! negative regulation of heart contraction
relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure

[Term]
id: GO:0001987
name: vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"]
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0001988
name: positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressure
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "activation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW []
synonym: "positive control of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT []
synonym: "positive regulation of cardiac contraction rate in baroreceptor response to decreased blood pressure" EXACT []
synonym: "positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure" RELATED []
synonym: "stimulation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW []
synonym: "up regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT []
synonym: "up-regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT []
synonym: "upregulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT []
is_a: GO:0010460 ! positive regulation of heart rate
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0001989
name: positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure
namespace: biological_process
def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to decreased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" EXACT []
synonym: "increased strength of cardiac contraction during baroreceptor response to decreased blood pressure" RELATED []
is_a: GO:0045823 ! positive regulation of heart contraction
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0001990
name: regulation of systemic arterial blood pressure by hormone
namespace: biological_process
def: "The process by which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "blood pressure regulation by hormone" EXACT []
synonym: "hormonal control of blood pressure" RELATED []
synonym: "hormonal regulation of blood pressure" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal
is_a: GO:0050886 ! endocrine process

[Term]
id: GO:0001991
name: regulation of systemic arterial blood pressure by circulatory renin-angiotensin
namespace: biological_process
def: "The process by which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen." [ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "circulatory renin-angiotensin blood pressure regulation" EXACT []
synonym: "circulatory renin-angiotensin control of blood pressure" RELATED []
synonym: "circulatory renin-angiotensin regulation of blood pressure" EXACT []
synonym: "control of blood pressure by circulatory renin-angiotensin" RELATED []
synonym: "renin-angiotensin blood pressure control" RELATED []
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin

[Term]
id: GO:0001992
name: regulation of systemic arterial blood pressure by vasopressin
namespace: biological_process
def: "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "blood pressure regulation by vasopressin" EXACT []
synonym: "vasopressin control of blood pressure" RELATED []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0001993
name: regulation of systemic arterial blood pressure by norepinephrine-epinephrine
namespace: biological_process
def: "The process by which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system." [ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "noradrenaline-adrenaline regulation of blood pressure" RELATED []
synonym: "norepinephrine-epinephrine blood pressure control" RELATED []
synonym: "norepinephrine-epinephrine blood pressure regulation" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal

[Term]
id: GO:0001994
name: norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure" EXACT []
synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure control" RELATED []
synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure regulation" EXACT []
synonym: "norepinephrine-epinephrine vasoconstriction during control of blood pressure" RELATED []
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine

[Term]
id: GO:0001995
name: norepinephrine-epinephrine catabolic process in blood stream
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream." [GOC:hjd]
synonym: "noradrenaline-adrenalin catabolic process in blood stream" EXACT []
is_a: GO:0042419 ! epinephrine catabolic process
relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine

[Term]
id: GO:0001996
name: positive regulation of heart rate by epinephrine-norepinephrine
namespace: biological_process
def: "The process by which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction." [GOC:dph]
synonym: "activation of heart contraction rate by epinephrine-norepinephrine" NARROW []
synonym: "increased chronotropy by epinephrine-norepinephrine" RELATED []
synonym: "positive control of heart contraction rate by epinephrine-norepinephrine" RELATED []
synonym: "positive regulation of cardiac contraction rate by epinephrine-norepinephrine" EXACT []
synonym: "positive regulation of heart contraction rate by adrenaline-noradrenaline" EXACT []
synonym: "positive regulation of heart contraction rate by epinephrine-norepinephrine" RELATED []
synonym: "stimulation of heart contraction rate by epinephrine-norepinephrine" NARROW []
synonym: "up regulation of heart contraction rate by epinephrine-norepinephrine" EXACT []
synonym: "up-regulation of heart contraction rate by epinephrine-norepinephrine" EXACT []
synonym: "upregulation of heart contraction rate by epinephrine-norepinephrine" EXACT []
is_a: GO:0010460 ! positive regulation of heart rate
relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine

[Term]
id: GO:0001997
name: positive regulation of the force of heart contraction by epinephrine-norepinephrine
namespace: biological_process
def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings." [GOC:dph, GOC:mtg_cardio]
synonym: "increased force of heart contraction by adrenaline-noradrenaline" EXACT []
synonym: "increased force of heart contraction by epinephrine-norepinephrine" EXACT []
synonym: "increased inotropy by epinephrine-norepinephrine " RELATED []
synonym: "increased strength of cardiac contraction by epinephrine-norepinephrine" EXACT []
synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED []
synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED []
is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal
relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine

[Term]
id: GO:0001998
name: angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "angiotensin mediated vasoconstriction during blood pressure control" RELATED []
synonym: "angiotensin mediated vasoconstriction during blood pressure regulation" EXACT []
synonym: "angiotensin mediated vasoconstriction during control of blood pressure" RELATED []
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0002034 ! regulation of blood vessel size by renin-angiotensin

[Term]
id: GO:0001999
name: renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressure
namespace: biological_process
def: "The physiological response of the kidneys to a decrease in blood flow." [GOC:dph]
synonym: "renal response to blood flow during renin-angiotensin control of blood pressure" RELATED []
is_a: GO:0003014 ! renal system process
relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin

[Term]
id: GO:0002000
name: detection of renal blood flow
namespace: biological_process
def: "The process by which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal." [ISBN:0721643949 "Textbook of Medical Physiology"]
is_a: GO:0050982 ! detection of mechanical stimulus
relationship: part_of GO:0001999 ! renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressure

[Term]
id: GO:0002001
name: renin secretion into blood stream
namespace: biological_process
def: "The regulated release of renin into the blood stream by juxtoglomerular cells." [ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "renin release into blood stream" EXACT []
is_a: GO:0009306 ! protein secretion
relationship: part_of GO:0001999 ! renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressure

[Term]
id: GO:0002002
name: regulation of angiotensin levels in blood
namespace: biological_process
def: "The process that modulates the level of angiotensin in the blood by balancing the maturation of renin substrate to mature angiotensin and the catabolism of mature angiotensin." [GOC:dph]
synonym: "control of angiotensin levels in blood" RELATED []
synonym: "control of blood angiotensin level" RELATED []
synonym: "regulation of blood angiotensin level" EXACT []
is_a: GO:0010817 ! regulation of hormone levels
is_a: GO:0060177 ! regulation of angiotensin metabolic process
relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin

[Term]
id: GO:0002003
name: angiotensin maturation
namespace: biological_process
def: "The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood." [ISBN:0721643949 "Textbook of Medical Physiology"]
is_a: GO:0016486 ! peptide hormone processing
relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood

[Term]
id: GO:0002004
name: secretion of vasopressin during fast regulation of systemic arterial blood pressure
namespace: biological_process
def: "The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland during fast regulation of blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "secretion of vasopressin during fast control of blood pressure" EXACT []
is_a: GO:0030103 ! vasopressin secretion
relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin

[Term]
id: GO:0002005
name: angiotensin catabolic process in blood
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of angiotensin in the blood." [ISBN:0721643949 "Textbook of Medical Physiology"]
is_a: GO:0044254 ! multicellular organismal protein catabolic process
relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood

[Term]
id: GO:0002006
name: vasoconstriction by vasopressin involved in systemic arterial blood pressure control
namespace: biological_process
def: "The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin

[Term]
id: GO:0002007
name: detection of hypoxic conditions in blood by chemoreceptor signaling
namespace: biological_process
def: "The process by which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:dph]
synonym: "detection of hypoxic conditions in blood by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0010850 ! chemoreceptor signaling pathway involved in regulation of blood pressure
is_a: GO:0070887 ! cellular response to chemical stimulus
relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling

[Term]
id: GO:0002008
name: excitation of vasomotor center by chemoreceptor signaling
namespace: biological_process
def: "The process by which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:dph]
synonym: "excitation of vasomotor center by chemoreceptor signalling" EXACT []
is_a: GO:0050877 ! neurological system process
relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling
relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure

[Term]
id: GO:0002009
name: morphogenesis of an epithelium
namespace: biological_process
def: "The process by which the anatomical structures of epithelia are generated and organized. Morphogenesis pertains to the creation of form. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0060429 ! epithelium development

[Term]
id: GO:0002010
name: excitation of vasomotor center by baroreceptor signaling
namespace: biological_process
def: "The process by which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure." [GOC:dph]
synonym: "excitation of vasomotor center by baroreceptor signalling" EXACT []
is_a: GO:0050877 ! neurological system process
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0002011
name: morphogenesis of an epithelial sheet
namespace: biological_process
def: "The process by which the anatomical structures of an epithelial sheet are generated and organized. Morphogenesis pertains to the creation of form. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0002012
name: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:dph, GOC:mtg_cardio]
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling

[Term]
id: GO:0002013
name: detection of carbon dioxide by vasomotor center
namespace: biological_process
def: "The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system." [ISBN:0721643949 "Textbook of Medical Physiology"]
is_a: GO:0003031 ! detection of carbon dioxide
relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions

[Term]
id: GO:0002014
name: vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"]
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure
is_a: GO:0042310 ! vasoconstriction
relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions

[Term]
id: GO:0002015
name: regulation of systemic arterial blood pressure by atrial baroreceptor feedback
namespace: biological_process
def: "A process that controls blood pressure by sensing the amount of stretch occurring in the atria." [GOC:dph, GOC:tb]
synonym: "atrial baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "atrial control of blood pressure" RELATED []
synonym: "atrial low pressure baroreceptor regulation of blood pressure" EXACT [GOC:mtg_cardio]
synonym: "atrial reflex" RELATED [GOC:dph]
is_a: GO:0003015 ! heart process
relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback

[Term]
id: GO:0002016
name: regulation of blood volume by renin-angiotensin
namespace: biological_process
def: "The process by which the renin-angiotensin system controls the rate of fluid intake and output into the blood." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "renin-angiotensin control of body fluid levels" RELATED []
synonym: "renin-angiotensin regulation of blood volume" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin

[Term]
id: GO:0002017
name: regulation of blood volume by renal aldosterone
namespace: biological_process
def: "The process by which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "aldosterone mediated control of body fluids" RELATED []
synonym: "aldosterone mediated regulation of blood volume" EXACT [GOC:dph, GOC:tb]
synonym: "renal regulation of blood volume by aldosterone" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001977 ! renal system process involved in regulation of blood volume
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure

[Term]
id: GO:0002018
name: renin-angiotensin regulation of aldosterone production
namespace: biological_process
def: "The process by which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone." [ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "renin-angiotensin control of aldosterone production" RELATED []
is_a: GO:0003014 ! renal system process
relationship: part_of GO:0002016 ! regulation of blood volume by renin-angiotensin

[Term]
id: GO:0002019
name: regulation of renal output by angiotensin
namespace: biological_process
def: "The process by which angiotensin directly modulates the rate of urine output by the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "angiotensin mediated control of renal output" RELATED []
synonym: "angiotensin mediated regulation of renal output" EXACT [GOC:dph, GOC:tb]
synonym: "angiotensin-mediated regulation of renal output" EXACT [GOC:dph, GOC:tb]
is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin

[Term]
id: GO:0002020
name: protease binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protease or peptidase." [GOC:hjd]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0002021
name: response to dietary excess
namespace: biological_process
def: "The physiological process by which dietary excess is sensed by the central nervous system and results in a reduction in food intake and increased energy expenditure." [PMID:12161655]
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0050896 ! response to stimulus
relationship: part_of GO:0040014 ! regulation of multicellular organism growth

[Term]
id: GO:0002022
name: detection of dietary excess
namespace: biological_process
def: "The mechanism by which the brain senses excessive caloric intake." [PMID:12161655]
is_a: GO:0050877 ! neurological system process
relationship: part_of GO:0002021 ! response to dietary excess

[Term]
id: GO:0002023
name: reduction of food intake in response to dietary excess
namespace: biological_process
def: "The specific actions of an organism that are triggered by the detection of dietary excess and result in a decreased intake of food." [PMID:12161655]
is_a: GO:0042755 ! eating behavior
relationship: part_of GO:0002021 ! response to dietary excess

[Term]
id: GO:0002024
name: diet induced thermogenesis
namespace: biological_process
def: "The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system." [PMID:12161655]
is_a: GO:0044253 ! positive regulation of multicellular organismal metabolic process
relationship: part_of GO:0002021 ! response to dietary excess

[Term]
id: GO:0002025
name: vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change." [GOC:mtg_cardio, PMID:10358008]
synonym: "noradrenaline-adrenaline vasodilation involved in regulation of blood pressure" EXACT []
synonym: "norepinephrine-epinephrine vasodilation during blood pressure regulation" EXACT []
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine

[Term]
id: GO:0002026
name: regulation of the force of heart contraction
namespace: biological_process
def: "Any process that modulates the extent of heart contraction, changing the force with which blood is propelled." [GOC:dph, GOC:tb, PMID:10358008]
synonym: "cardiac inotropy" EXACT [GOC:dph, GOC:tb]
synonym: "heart inotropy" EXACT []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0002027
name: regulation of heart rate
namespace: biological_process
def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008]
synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of heart contraction rate" EXACT []
synonym: "regulation of rate of heart contraction" EXACT []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0002028
name: regulation of sodium ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:dph]
synonym: "regulation of Na+ transport" EXACT []
synonym: "regulation of sodium transport" EXACT []
is_a: GO:0010959 ! regulation of metal ion transport
relationship: regulates GO:0006814 ! sodium ion transport

[Term]
id: GO:0002029
name: desensitization of G-protein coupled receptor protein signaling pathway
namespace: biological_process
def: "The process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity after prolonged stimulation with an agonist of the pathway." [PMID:8396717]
synonym: "desensitisation of G-protein coupled receptor protein signalling pathway" EXACT []
is_a: GO:0022401 ! negative adaptation of signaling pathway
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0002030
name: inhibitory G-protein coupled receptor phosphorylation
namespace: biological_process
def: "The process that inhibits the signaling function of a G-protein coupled receptor by addition of a phosphate group to its third intracellular loop consensus site." [PMID:8396717]
is_a: GO:0006468 ! protein amino acid phosphorylation
relationship: part_of GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0002031
name: G-protein coupled receptor internalization
namespace: biological_process
def: "The process by which a G-protein coupled receptor is taken up into an endocytic vesicle." [PMID:8396717]
is_a: GO:0031623 ! receptor internalization
relationship: part_of GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0002032
name: desensitization of G-protein coupled receptor protein signaling pathway by arrestin
namespace: biological_process
def: "The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins." [GOC:dph, GOC:tb, PMID:8396717]
synonym: "arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT []
is_a: GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway
is_a: GO:0032091 ! negative regulation of protein binding

[Term]
id: GO:0002033
name: vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that increases the size of a blood vessel via the renin-angiotensin system." [ISBN:0323031951 "Principles of Physiology", PMID:10425188]
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0002034 ! regulation of blood vessel size by renin-angiotensin

[Term]
id: GO:0002034
name: regulation of blood vessel size by renin-angiotensin
namespace: biological_process
def: "The process where the diameter of a blood vessel is changed due to activity of the renin-angiotensin system." [GOC:dph, GOC:tb]
synonym: "renin-angiotensin regulation of blood vessel size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin
is_a: GO:0050880 ! regulation of blood vessel size

[Term]
id: GO:0002035
name: brain renin-angiotensin system
namespace: biological_process
def: "The process by which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system." [PMID:2909574]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin

[Term]
id: GO:0002036
name: regulation of L-glutamate transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-glutamate transport." [GOC:hjd]
is_a: GO:0044070 ! regulation of anion transport
is_a: GO:0051955 ! regulation of amino acid transport
relationship: regulates GO:0015813 ! L-glutamate transport

[Term]
id: GO:0002037
name: negative regulation of L-glutamate transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate transport." [GOC:hjd]
synonym: "down regulation of L-glutamate transport" EXACT []
synonym: "down-regulation of L-glutamate transport" EXACT []
synonym: "downregulation of L-glutamate transport" EXACT []
synonym: "inhibition of L-glutamate transport" NARROW []
is_a: GO:0002036 ! regulation of L-glutamate transport
is_a: GO:0043271 ! negative regulation of ion transport
is_a: GO:0051956 ! negative regulation of amino acid transport
relationship: negatively_regulates GO:0015813 ! L-glutamate transport

[Term]
id: GO:0002038
name: positive regulation of L-glutamate transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of L-glutamate transport." [GOC:hjd]
synonym: "activation of L-glutamate transport" NARROW []
synonym: "stimulation of L-glutamate transport" NARROW []
synonym: "up regulation of L-glutamate transport" EXACT []
synonym: "up-regulation of L-glutamate transport" EXACT []
synonym: "upregulation of L-glutamate transport" EXACT []
is_a: GO:0002036 ! regulation of L-glutamate transport
is_a: GO:0043270 ! positive regulation of ion transport
is_a: GO:0051957 ! positive regulation of amino acid transport
relationship: positively_regulates GO:0015813 ! L-glutamate transport

[Term]
id: GO:0002039
name: p53 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with one of the p53 family of proteins." [GOC:hjd]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0002040
name: sprouting angiogenesis
namespace: biological_process
def: "The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells." [PMID:16391003]
is_a: GO:0001525 ! angiogenesis

[Term]
id: GO:0002041
name: intussusceptive angiogenesis
namespace: biological_process
def: "The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars." [PMID:16391003]
is_a: GO:0001525 ! angiogenesis

[Term]
id: GO:0002042
name: cell migration involved in sprouting angiogenesis
namespace: biological_process
def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis." [PMID:16391003]
is_a: GO:0043534 ! blood vessel endothelial cell migration
relationship: part_of GO:0002040 ! sprouting angiogenesis

[Term]
id: GO:0002043
name: blood vessel endothelial cell proliferation during sprouting angiogenesis
namespace: biological_process
def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population during sprouting angiogenesis." [PMID:16391003]
is_a: GO:0001935 ! endothelial cell proliferation
relationship: part_of GO:0002040 ! sprouting angiogenesis

[Term]
id: GO:0002044
name: blood vessel endothelial cell migration involved in intussusceptive angiogenesis
namespace: biological_process
def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis." [PMID:16391003]
is_a: GO:0043534 ! blood vessel endothelial cell migration
relationship: part_of GO:0002041 ! intussusceptive angiogenesis

[Term]
id: GO:0002045
name: regulation of cell adhesion involved in intussusceptive angiogenesis
namespace: biological_process
def: "The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis." [PMID:16391003]
is_a: GO:0030155 ! regulation of cell adhesion
relationship: part_of GO:0002041 ! intussusceptive angiogenesis

[Term]
id: GO:0002046
name: opsin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception." [GOC:hjd]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0002047
name: phenazine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring." [GOC:dph]
subset: gosubset_prok
synonym: "acridizine biosynthesis" RELATED []
synonym: "acridizine biosynthetic process" RELATED []
synonym: "azophenylene biosynthesis" RELATED []
synonym: "azophenylene biosynthetic process" RELATED []
synonym: "dibenzo-p-diazine biosynthesis" RELATED []
synonym: "dibenzo-p-diazine biosynthetic process" RELATED []
synonym: "dibenzopyrazine biosynthesis" RELATED []
synonym: "dibenzopyrazine biosynthetic process" RELATED []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process

[Term]
id: GO:0002048
name: pyoverdine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the siderochrome pyoverdine." [PMID:15317763]
synonym: "pyoverdine metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process

[Term]
id: GO:0002049
name: pyoverdine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine." [PMID:15317763]
is_a: GO:0002048 ! pyoverdine metabolic process
is_a: GO:0019290 ! siderophore biosynthetic process

[Term]
id: GO:0002050
name: pyoverdine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine." [PMID:15317763]
is_a: GO:0002048 ! pyoverdine metabolic process
is_a: GO:0046215 ! siderophore catabolic process

[Term]
id: GO:0002051
name: osteoblast fate commitment
namespace: biological_process
def: "The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0002052
name: positive regulation of neuroblast proliferation
namespace: biological_process
def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph]
synonym: "activation of neuroblast proliferation" NARROW []
synonym: "stimulation of neuroblast proliferation" NARROW []
synonym: "up regulation of neuroblast proliferation" EXACT []
synonym: "up-regulation of neuroblast proliferation" EXACT []
synonym: "upregulation of neuroblast proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0050769 ! positive regulation of neurogenesis
relationship: positively_regulates GO:0007405 ! neuroblast proliferation

[Term]
id: GO:0002053
name: positive regulation of mesenchymal cell proliferation
namespace: biological_process
def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph]
synonym: "activation of mesenchymal cell proliferation" NARROW []
synonym: "stimulation of mesenchymal cell proliferation" NARROW []
synonym: "up regulation of mesenchymal cell proliferation" EXACT []
synonym: "up-regulation of mesenchymal cell proliferation" EXACT []
synonym: "upregulation of mesenchymal cell proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
relationship: positively_regulates GO:0010463 ! mesenchymal cell proliferation

[Term]
id: GO:0002054
name: nucleobase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases." [GOC:hjd]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0002055
name: adenine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with adenine, a purine base." [GOC:hjd]
synonym: "6-aminopurine binding" EXACT []
is_a: GO:0002060 ! purine binding

[Term]
id: GO:0002056
name: cytosine binding
namespace: molecular_function
def: "Interactiing selectively with cytosine." [GOC:hjd]
is_a: GO:0002061 ! pyrimidine binding

[Term]
id: GO:0002057
name: guanine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with guanine." [GOC:hjd]
is_a: GO:0002060 ! purine binding

[Term]
id: GO:0002058
name: uracil binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with uracil." [GOC:hjd]
is_a: GO:0002061 ! pyrimidine binding

[Term]
id: GO:0002059
name: thymine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with thymine." [GOC:hjd]
is_a: GO:0002061 ! pyrimidine binding

[Term]
id: GO:0002060
name: purine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a purine, an organic nitrogenous base." [GOC:hjd]
is_a: GO:0002054 ! nucleobase binding

[Term]
id: GO:0002061
name: pyrimidine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pyrimidine, an organic nitrogenous base." [GOC:hjd]
synonym: "1,3-diazine binding" EXACT []
is_a: GO:0002054 ! nucleobase binding

[Term]
id: GO:0002062
name: chondrocyte differentiation
namespace: biological_process
def: "The process whereby a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0051216 ! cartilage development

[Term]
id: GO:0002063
name: chondrocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0002062 ! chondrocyte differentiation

[Term]
id: GO:0002064
name: epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0002065
name: columnar/cuboidal epithelial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0002066
name: columnar/cuboidal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0002065 ! columnar/cuboidal epithelial cell differentiation

[Term]
id: GO:0002067
name: glandular epithelial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation

[Term]
id: GO:0002068
name: glandular epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002066 ! columnar/cuboidal epithelial cell development
relationship: part_of GO:0002067 ! glandular epithelial cell differentiation

[Term]
id: GO:0002069
name: columnar/cuboidal epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]
is_a: GO:0002070 ! epithelial cell maturation
relationship: part_of GO:0002066 ! columnar/cuboidal epithelial cell development

[Term]
id: GO:0002070
name: epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0002064 ! epithelial cell development

[Term]
id: GO:0002071
name: glandular epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]
is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation
relationship: part_of GO:0002068 ! glandular epithelial cell development

[Term]
id: GO:0002072
name: optic cup morphogenesis involved in camera-type eye development
namespace: biological_process
def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437]
synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT []
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0060900 ! embryonic camera-type eye formation

[Term]
id: GO:0002074
name: extraocular skeletal muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_muscle, GOC:mtg_sensu, MA:0001271, PMID:16638982]
is_a: GO:0007519 ! skeletal muscle tissue development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0002075
name: somitomeric trunk muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, PMID:16638982]
is_a: GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0002076
name: osteoblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0002077
name: acrosome matrix dispersal
namespace: biological_process
def: "The proteolytic digestion of components in the acrosomal matrix that allows for their release into the egg. The dispersal of the components allows for the inner acrosomal membrane to interact with the egg." [GOC:dph, PMID:3886029]
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0002078
name: membrane fusion involved in acrosome reaction
namespace: biological_process
def: "The fusion of the plasma membrane of the sperm with the outer acrosomal membrane." [GOC:dph, PMID:3886029]
synonym: "membrane fusion involved in the acrosomal reaction" EXACT []
is_a: GO:0006944 ! cellular membrane fusion
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0002079
name: inner acrosomal membrane
namespace: cellular_component
def: "The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane." [GOC:dph, PMID:3899643, PMID:8936405]
comment: Note that this term is not a descendant of 'organelle inner membrane ; GO:0019866' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer.
is_a: GO:0044425 ! membrane part
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0002080 ! acrosomal membrane

[Term]
id: GO:0002080
name: acrosomal membrane
namespace: cellular_component
def: "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0001669 ! acrosomal vesicle

[Term]
id: GO:0002081
name: outer acrosomal membrane
namespace: cellular_component
def: "The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction." [GOC:dph, PMID:8936405]
comment: Note that this term is not a descendant of 'organelle outer membrane ; GO:0031968' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer.
is_a: GO:0044425 ! membrane part
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0002080 ! acrosomal membrane

[Term]
id: GO:0002082
name: regulation of oxidative phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:dph]
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
relationship: regulates GO:0006119 ! oxidative phosphorylation

[Term]
id: GO:0002083
name: 4-hydroxybenzoate decaprenyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: decaprenyl-PP + p-hydroxybenzoate = decaprenyl-4-hydroxybenzoate + diphosphate." [GOC:hjd]
is_a: GO:0002094 ! polyprenyltransferase activity

[Term]
id: GO:0002084
name: protein depalmitoylation
namespace: biological_process
def: "The removal of palymitoyl groups from a lipoprotein." [GOC:hjd]
is_a: GO:0006464 ! protein modification process
is_a: GO:0042159 ! lipoprotein catabolic process

[Term]
id: GO:0002085
name: inhibition of neuroepithelial cell differentiation
namespace: biological_process
def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process by which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814]
synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb]
synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tairtb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0048505 ! regulation of timing of cell differentiation
relationship: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation

[Term]
id: GO:0002086
name: diaphragm contraction
namespace: biological_process
def: "A process whereby force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange." [GOC:dph, GOC:mtg_muscle, PMID:12458206]
is_a: GO:0003011 ! involuntary skeletal muscle contraction
is_a: GO:0003016 ! respiratory system process

[Term]
id: GO:0002087
name: regulation of respiratory gaseous exchange by neurological system process
namespace: biological_process
def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206]
synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb]
is_a: GO:0044065 ! regulation of respiratory system process
is_a: GO:0050877 ! neurological system process

[Term]
id: GO:0002088
name: lens development in camera-type eye
namespace: biological_process
def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333]
synonym: "lens development" EXACT []
synonym: "lens development in camera-style eye" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0002089
name: lens morphogenesis in camera-type eye
namespace: biological_process
def: "The process by which the anatomical structures of the lens are generated and organized. Morphogenesis pertains to the creation of form. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu]
synonym: "lens morphogenesis" EXACT []
synonym: "lens morphogenesis in camera-style eye" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0002088 ! lens development in camera-type eye
relationship: part_of GO:0048593 ! camera-type eye morphogenesis

[Term]
id: GO:0002090
name: regulation of receptor internalization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor internalization." [GOC:hjd]
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0048259 ! regulation of receptor-mediated endocytosis
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0031623 ! receptor internalization

[Term]
id: GO:0002091
name: negative regulation of receptor internalization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor internalization." [GOC:hjd]
synonym: "down regulation of receptor internalization" EXACT []
synonym: "down-regulation of receptor internalization" EXACT []
synonym: "downregulation of receptor internalization" EXACT []
synonym: "inhibition of receptor internalization" NARROW []
is_a: GO:0002090 ! regulation of receptor internalization
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis
relationship: negatively_regulates GO:0031623 ! receptor internalization

[Term]
id: GO:0002092
name: positive regulation of receptor internalization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor internalization." [GOC:hjd]
synonym: "activation of receptor internalization" NARROW []
synonym: "stimulation of receptor internalization" NARROW []
synonym: "up regulation of receptor internalization" EXACT []
synonym: "up-regulation of receptor internalization" EXACT []
synonym: "upregulation of receptor internalization" EXACT []
is_a: GO:0002090 ! regulation of receptor internalization
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis
relationship: positively_regulates GO:0031623 ! receptor internalization

[Term]
id: GO:0002093
name: auditory receptor cell morphogenesis
namespace: biological_process
def: "Any process that alters the size or shape of an auditory receptor cell." [GOC:dph, GOC:tb]
synonym: "hair cell morphogenesis" BROAD [GO:dph]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0060117 ! auditory receptor cell development

[Term]
id: GO:0002094
name: polyprenyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)." [GOC:hjd]
subset: gosubset_prok
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0002095
name: caveolar macromolecular signaling complex
namespace: cellular_component
def: "A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3)." [PMID:16648270]
synonym: "caveolar macromolecular signalling complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005901 ! caveola

[Term]
id: GO:0002096
name: polkadots
namespace: cellular_component
def: "A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals." [PMID:14724296, PMID:16495340]
comment: Note that polkadots also contains some amount of MALT1. Interaction with MALT1 is required for formation of the polkadots.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0002097
name: tRNA wobble base modification
namespace: biological_process
def: "The process whereby the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0002098
name: tRNA wobble uridine modification
namespace: biological_process
def: "The process whereby a uridine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002097 ! tRNA wobble base modification

[Term]
id: GO:0002099
name: tRNA wobble guanine modification
namespace: biological_process
def: "The process whereby a guanine in t position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002097 ! tRNA wobble base modification

[Term]
id: GO:0002100
name: tRNA wobble adenosine to inosine editing
namespace: biological_process
def: "The process whereby an adenosine in position 34 of a tRNA is post-transcriptionally corverted to inosine." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002097 ! tRNA wobble base modification

[Term]
id: GO:0002101
name: tRNA wobble cytosine modification
namespace: biological_process
def: "The process whereby a cytosine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002097 ! tRNA wobble base modification

[Term]
id: GO:0002102
name: podosome
namespace: cellular_component
def: "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982]
comment: Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation.
xref: Wikipedia:Podosome
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0002103
name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0000478 ! endonucleolytic cleavages during rRNA processing

[Term]
id: GO:0002104
name: endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

[Term]
id: GO:0002105
name: endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

[Term]
id: GO:0002106
name: endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def: "Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]
is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

[Term]
id: GO:0002107
name: generation of mature 3'-end of 5S rRNA generated by RNA polymerase III
namespace: biological_process
def: "The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end." [GOC:hjd, PMID:16387655, PMID:1748637, PMID:1902221, PMID:8389357]
is_a: GO:0000481 ! maturation of 5S rRNA
is_a: GO:0031125 ! rRNA 3'-end processing

[Term]
id: GO:0002108
name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0000470 ! maturation of LSU-rRNA

[Term]
id: GO:0002109
name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]
is_a: GO:0030490 ! maturation of SSU-rRNA

[Term]
id: GO:0002110
name: cotranscriptional mitochondrial rRNA nucleotide insertion
namespace: biological_process
def: "The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA", PMID:8306965]
is_a: GO:0000154 ! rRNA modification
is_a: GO:0070705 ! RNA nucleotide insertion

[Term]
id: GO:0002111
name: BRCA2-BRAF35 complex
namespace: cellular_component
def: "A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis." [GOC:hjd, PMID:11207365]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0002112
name: interleukin-33 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-33 receptor." [GOC:hjd]
synonym: "IL-33" NARROW [GOC:mah]
synonym: "interleukin-33 receptor ligand" NARROW [GOC:mah]
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0002113
name: interleukin-33 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-33." [GOC:hjd]
synonym: "IL-33 binding" EXACT [GOC:mah]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0002114
name: interleukin-33 receptor activity
namespace: molecular_function
def: "Combining with interleukin-33 to initiate a change in cell activity." [GOC:hjd]
synonym: "IL-33 receptor activity" EXACT [GOC:mah]
synonym: "IL-33R" EXACT [GOC:mah]
is_a: GO:0002113 ! interleukin-33 binding
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0002115
name: store-operated calcium entry
namespace: biological_process
def: "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991]
comment: SOCE is initiated by response to stiumlation of membrane receptors leading to the hydrolysis ofphosphatidylinositol bisphosphate (PIP2), inositol 1,4,5-trisphosphate (IP3) generation, and IP3-mediated calcium ion release from the endoplasmic reticulum.
synonym: "calcium ion import" BROAD []
synonym: "capacitative calcium entry" EXACT []
synonym: "SOCE" EXACT []
synonym: "store-operated calcium import" EXACT []
is_a: GO:0006816 ! calcium ion transport

[Term]
id: GO:0002116
name: semaphorin receptor complex
namespace: cellular_component
def: "A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor." [GOC:hjd, PMID:10934324, PMID:12367632, PMID:12613544]
synonym: "plexin-neurophilin complex" EXACT []
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0002117
name: amphibian larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form." [GOC:go_curators, GOC:rf, http://www.livingunderworld.org/biology/]
is_a: GO:0002164 ! larval development

[Term]
id: GO:0002118
name: aggressive behavior
namespace: biological_process
def: "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd]
synonym: "aggression" EXACT []
xref: Wikipedia:Aggression
is_a: GO:0051705 ! behavioral interaction between organisms

[Term]
id: GO:0002119
name: nematode larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:ems, GOC:kmv]
is_a: GO:0002164 ! larval development

[Term]
id: GO:0002120
name: predatory aggressive behavior
namespace: biological_process
def: "Aggressive behavior involving attack on prey by a predator, characterized by lack of threatening displays, silence, and no sex differences." [GOC:hjd]
synonym: "predatory aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002121
name: inter-male aggressive behavior
namespace: biological_process
def: "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]
synonym: "inter-male aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002122
name: fear-induced aggressive behavior
namespace: biological_process
def: "Aggressive behavior associated with attempts to flee from a threat." [GOC:hjd]
synonym: "fear-induced aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002123
name: irritable aggressive behavior
namespace: biological_process
def: "Aggressive behavior induced by frustration and directed against an available target." [GOC:hjd]
synonym: "irritable aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002124
name: territorial aggressive behavior
namespace: biological_process
def: "Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics." [GOC:hjd]
synonym: "territorial aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002125
name: maternal aggressive behavior
namespace: biological_process
def: "Aggressive behavior of a female to protect her offspring from a threat." [GOC:hjd]
comment: Paternal aggression also exists. Serves to protect the offspring from intruders.
synonym: "maternal aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002126
name: instrumental aggressive behavior
namespace: biological_process
def: "Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation." [GOC:hjd]
synonym: "instrumental aggression" EXACT []
is_a: GO:0002118 ! aggressive behavior

[Term]
id: GO:0002127
name: wobble base cytosine methylation
namespace: biological_process
def: "The process whereby the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position." [GOC:hjd, ISBN:155581073X]
synonym: "wobble position m5C biosynthesis" EXACT []
is_a: GO:0002101 ! tRNA wobble cytosine modification
is_a: GO:0030488 ! tRNA methylation

[Term]
id: GO:0002128
name: tRNA nucleoside ribose methylation
namespace: biological_process
def: "The process by which the sugar of a nucleoside in tRNA is modified at the 2'O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0030488 ! tRNA methylation

[Term]
id: GO:0002129
name: wobble position guanine ribose methylation
namespace: biological_process
def: "The process whereby the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002130 ! wobble position ribose methylation

[Term]
id: GO:0002130
name: wobble position ribose methylation
namespace: biological_process
def: "The process whereby the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002128 ! tRNA nucleoside ribose methylation

[Term]
id: GO:0002131
name: wobble position cytosine ribose methylation
namespace: biological_process
def: "The process whereby the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002130 ! wobble position ribose methylation

[Term]
id: GO:0002132
name: wobble position uridine ribose methylation
namespace: biological_process
def: "The process whereby the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X]
is_a: GO:0002130 ! wobble position ribose methylation

[Term]
id: GO:0002133
name: polycystin complex
namespace: cellular_component
def: "A stable heterodimeric complex composed of polycystin-1 and polycystin-2." [GOC:hjd, PMID:11901144]
comment: Different forms of the complex differing in type of N-glycosylation of polycystin-1 can exist (endoglycosidase sensitive and endoglycosidase resistant).
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0002134
name: UTP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary"]
is_a: GO:0032557 ! pyrimidine ribonucleotide binding

[Term]
id: GO:0002135
name: CTP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with CTP, cytidine 5'-triphosphate." [GOC:hjd, ISBN:0124020607 "The Anatomical Basis of Mouse Development"]
is_a: GO:0032557 ! pyrimidine ribonucleotide binding

[Term]
id: GO:0002136
name: wobble base lysidine biosynthesis
namespace: biological_process
def: "The process whereby the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine." [PMID:15894617]
comment: Exclusively located at the anticodon wobble position (i.e., position 34) of eubacterial and some organellar tRNAIle2. This modification converts the codon specificity from AUG to AUA, and it also converts the aminoacylation specificity of the tRNA from methionine to isoleucine. Requires ATP.
is_a: GO:0002101 ! tRNA wobble cytosine modification

[Term]
id: GO:0002137
name: nuclear cluster
namespace: cellular_component
def: "Discrete hetero-chromatin-containing foci in interphase nuclei, which comprise clusters of centromeric DNA (as defined by gamma-satellite sequences and the abundance of heterochromatin protein 1 (HP-1) ." [PMID:9413993]
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031618 ! nuclear centromeric heterochromatin

[Term]
id: GO:0002138
name: retinoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A." [GOC:hjd]
synonym: "retinoic acid anabolic process" EXACT []
is_a: GO:0042573 ! retinoic acid metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0002139
name: stereocilia coupling link
namespace: cellular_component
def: "A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle." [PMID:16775142]
is_a: GO:0044464 ! cell part

[Term]
id: GO:0002140
name: stereocilia tip link
namespace: cellular_component
def: "A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia." [PMID:1108787]
is_a: GO:0002139 ! stereocilia coupling link

[Term]
id: GO:0002141
name: stereocilia ankle link
namespace: cellular_component
def: "A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia." [PMID:17567809]
is_a: GO:0002139 ! stereocilia coupling link

[Term]
id: GO:0002142
name: stereocilia ankle link complex
namespace: cellular_component
def: "A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin." [PMID:16775142]
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0002141 ! stereocilia ankle link

[Term]
id: GO:0002143
name: wobble position uridine thiolation
namespace: biological_process
def: "The process whereby a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:16871210]
comment: In E. coli, the first step of the reaction is reductive elimination of sulfur from L-cysteine by IscS cysteine desulfurase to form an enzyme-bound cysteine-persulfide intermediate. Then, five essential gene products, TusA, TusB, TusC, TusD and TusE, mediate a sulfur relay that delivers the terminal sulfur of persulfide from IscS to MnmA12. The last protein, MnmA catalyzes the transfer of the sulfur from IscS to an ATP activated U34 of the tRNA.
synonym: "tRNA wobble uridine thiolation" EXACT [GOC:mah]
synonym: "wobble position s2U biosynthesis" EXACT []
is_a: GO:0002098 ! tRNA wobble uridine modification
is_a: GO:0034227 ! tRNA thio-modification

[Term]
id: GO:0002144
name: cytosolic tRNA wobble base thiouridylase complex
namespace: cellular_component
def: "A complex of two proteins involved in the thiolation of U34 in glutamate, lysine, and glutamine tRNAs of eukaryotes." [PMID:18391219]
synonym: "Cut1-Cut2 complex" NARROW []
synonym: "tRNA thiouridylase" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0002145
name: 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity
namespace: molecular_function
def: "4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphate + water = 2-methyl-4-amino-5-hydroxymethyl pyrimidine monophosphate + phosphate." [GOC:hjd]
synonym: "HMP-PP diphosphatase" EXACT []
synonym: "HMP-PP pyrophosphatase" EXACT []
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0002146
name: steroid hormone receptor nuclear translocation
namespace: biological_process
def: "The directed movement of a steroid hormone receptor into the nucleus." [GOC:hjd]
is_a: GO:0000060 ! protein import into nucleus, translocation

[Term]
id: GO:0002147
name: glucocorticoid receptor nuclear translocation
namespace: biological_process
def: "The directed movement of a glucocorticoid receptor into the nucleus." [GOC:hjd]
is_a: GO:0002146 ! steroid hormone receptor nuclear translocation
relationship: part_of GO:0042921 ! glucocorticoid receptor signaling pathway

[Term]
id: GO:0002148
name: hypochlorous acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hypochlorous acid." [GOC:add, PMID:176150, PMIG:10085024]
synonym: "HClO metabolic process" EXACT []
synonym: "HOCl metabolic process" EXACT []
synonym: "hypochlorite metabolic process" RELATED []
synonym: "hypochlorous acid metabolism" EXACT []
is_a: GO:0070276 ! halogen metabolic process

[Term]
id: GO:0002149
name: hypochlorous acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hypochlorous acid." [GOC:add, PMID:10085024, PMID:176150]
comment: Note that this reaction is catalyzed by myeloperoxidase in neutrophils.
synonym: "HClO biosynthetic process" EXACT []
synonym: "HOCl biosynthetic process" EXACT []
synonym: "hypochlorite biosynthetic process" RELATED []
synonym: "hypochlorous acid biosynthesis" EXACT []
is_a: GO:0002148 ! hypochlorous acid metabolic process

[Term]
id: GO:0002150
name: hypochlorous acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hypochlorous acid." [GOC:add]
synonym: "HClO catabolic process" EXACT []
synonym: "HOCl catabolic process" EXACT []
synonym: "hypochlorite catabolic process" RELATED []
synonym: "hypochlorous acid catabolism" EXACT []
is_a: GO:0002148 ! hypochlorous acid metabolic process

[Term]
id: GO:0002151
name: G-quadruplex RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad." [PMID:18294969, PMID:18568163, PMID:19330720]
comment: The structures of RNA and DNA G quartets differ regarding sugar conformation so that a protein binding to the RNA structure might not bind to the DNA structure.
synonym: "G quadruplex binding" EXACT [GOC:mah]
synonym: "G quartet binding" BROAD [GOC:hjd]
synonym: "G quartet RNA binding" EXACT [GOC:hjd]
synonym: "G-quartet binding" BROAD [GOC:mah]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0002152
name: bile acid conjugation
namespace: biological_process
def: "The process whereby bile acids are covalently linked to taurine or glycine." [PMID:1094911, PMID:708413]
comment: The bile acid is first activated using CoA by cholate-CoA ligase activity(GO:0047747), then conjugated to taurine or glycine by glycine N-choloyltransferase activity (GO:0047963; appears to use either glycine or taurine).
is_a: GO:0008206 ! bile acid metabolic process

[Term]
id: GO:0002153
name: steroid receptor RNA activator RNA binding
namespace: molecular_function
def: "Selectively interacting with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding." [PMID:10199399, PMID:15180993]
comment: Note: there is also evidence that the RNA itself may code a protein (solution structure of mouse steroid receptor RNA activator 1 (SRA1) protein submitted to PDB by Riken).
synonym: "SRA binding" EXACT []
is_a: GO:0003727 ! single-stranded RNA binding

[Term]
id: GO:0002154
name: thyroid hormone mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by the detection of a thyroid hormone." [GOC:hjd]
is_a: GO:0009755 ! hormone-mediated signaling pathway

[Term]
id: GO:0002155
name: regulation of thyroid hormone mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway." [GOC:hjd]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0002154 ! thyroid hormone mediated signaling pathway

[Term]
id: GO:0002156
name: negative regulation of thyroid hormone mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd]
is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway

[Term]
id: GO:0002157
name: positive regulation of thyroid hormone mediated signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd]
is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway

[Term]
id: GO:0002158
name: osteoclast proliferation
namespace: biological_process
def: "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd]
is_a: GO:0070661 ! leukocyte proliferation

[Term]
id: GO:0002159
name: desmosome assembly
namespace: biological_process
def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732]
comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix.
is_a: GO:0007043 ! cell-cell junction assembly

[Term]
id: GO:0002160
name: desmosome maintenance
namespace: biological_process
def: "The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732]
comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix.
is_a: GO:0045217 ! cell-cell junction maintenance

[Term]
id: GO:0002161
name: aminoacyl-tRNA editing activity
namespace: molecular_function
def: "The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889\,]
synonym: "amino acid proofreading activity" RELATED []
synonym: "aminoacyl-tRNA hydrolysis activity" RELATED []
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0002162
name: dystroglycan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal)." [GOC:hjd]
is_a: GO:0001948 ! glycoprotein binding

[Term]
id: GO:0002163
name: alpha-dystroglycan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with alpha-dystroglycan. Alpha-dystroglycan is extracellular protein derived from cleavage of dystroglycan." [GOC:hjd]
is_a: GO:0002162 ! dystroglycan binding

[Term]
id: GO:0002164
name: larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of any animal when more or less of a metamorphosis takes place, before the assumption of the mature shape." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0002165
name: instar larval or pupal development
namespace: biological_process
def: "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jic, GOC:mtg_sensu]
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0002166
name: beta-dystroglycan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with beta-dystroglycan. Beta-dystroglycan is a transmembrane protein derived from cleavage of dystroglycan." [GOC:hjd]
is_a: GO:0002162 ! dystroglycan binding

[Term]
id: GO:0002168
name: instar larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0002164 ! larval development
is_a: GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0002200
name: somatic diversification of immune receptors
namespace: biological_process
def: "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16102575, PMID:16166509]
comment: Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification.
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0002520 ! immune system development

[Term]
id: GO:0002201
name: somatic diversification of DSCAM-based immune receptors
namespace: biological_process
def: "The somatic process by means of which sequence diversity of the DSCAM-based immune receptors of insects is generated." [GOC:add, PMID:16261174]
comment: Note that this type of immune receptor may not be limited to insects.
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002202
name: somatic diversification of variable lymphocyte receptors of jawless fish
namespace: biological_process
def: "The somatic process by means of which sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish is generated." [GOC:add, PMID:16373579]
comment: Note that jawless fish refers to both lampreys (Petremyzontidae, ncbi_taxonomy_id:7746) and hagfish (Myxinidae, ncbi_taxonomy_id:7762).
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002203
name: proteolysis by cytosolic proteases associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591]
comment: Note that a separate term covers proteolysis by the proteasome complex (proteasomal proteolysis associated with antigen processing and presentation ; GO:0002497).
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002204
name: somatic recombination of immunoglobulin genes during immune response
namespace: biological_process
def: "The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "somatic recombination of antibody genes during immune response" EXACT []
is_a: GO:0002208 ! somatic diversification of immunoglobulins during immune response
is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments

[Term]
id: GO:0002205
name: somatic hypermutation of immunoglobulin genes during immune response
namespace: biological_process
def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11205333, PMID:14991701]
synonym: "somatic hypermutation of antibody genes during immune response" EXACT []
is_a: GO:0002208 ! somatic diversification of immunoglobulins during immune response
is_a: GO:0016446 ! somatic hypermutation of immunoglobulin genes
relationship: part_of GO:0002344 ! B cell affinity maturation

[Term]
id: GO:0002206
name: gene conversion of immunoglobulin genes
namespace: biological_process
def: "The somatic process by which immunoglobulin genes are diversified through the mechanism of gene conversion." [GOC:add, PMID:14991701]
synonym: "gene conversion of antibody genes" EXACT []
is_a: GO:0002565 ! somatic diversification of immune receptors via gene conversion
is_a: GO:0016445 ! somatic diversification of immunoglobulins

[Term]
id: GO:0002207
name: gene conversion of immunoglobulin genes during immune response
namespace: biological_process
def: "The somatic process by which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of an immune response." [GOC:add, PMID:14991701]
synonym: "gene conversion of antibody genes during immune response" EXACT []
is_a: GO:0002206 ! gene conversion of immunoglobulin genes
is_a: GO:0002208 ! somatic diversification of immunoglobulins during immune response

[Term]
id: GO:0002208
name: somatic diversification of immunoglobulins during immune response
namespace: biological_process
def: "The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14991701]
synonym: "somatic diversification of antibodies during immune response" EXACT []
is_a: GO:0016445 ! somatic diversification of immunoglobulins
relationship: part_of GO:0002381 ! immunoglobulin production during immune response

[Term]
id: GO:0002209
name: behavioral defense response
namespace: biological_process
def: "A behavioral response seeking to protect an organism from an a perceived external threat to that organism." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
comment: This term was added by GO_REF:0000022.
synonym: "behavioural defense response" EXACT []
is_a: GO:0006952 ! defense response
is_a: GO:0007610 ! behavior

[Term]
id: GO:0002210
name: behavioral response to wounding
namespace: biological_process
def: "A behavioral response resulting from wounding." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
comment: This term was added by GO_REF:0000022.
synonym: "behavioural response to wounding" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0009611 ! response to wounding

[Term]
id: GO:0002211
name: behavioral defense response to insect
namespace: biological_process
def: "A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism." [GOC:add]
synonym: "behavioural defense response to insect" EXACT []
is_a: GO:0002209 ! behavioral defense response
is_a: GO:0002213 ! defense response to insect

[Term]
id: GO:0002212
name: behavioral defense response to nematode
namespace: biological_process
def: "A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism." [GOC:add, PMID:14506883]
synonym: "behavioural defense response to nematode" EXACT []
is_a: GO:0002209 ! behavioral defense response
is_a: GO:0002215 ! defense response to nematode

[Term]
id: GO:0002213
name: defense response to insect
namespace: biological_process
alt_id: GO:0002214
def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add]
synonym: "physiological defense response to insect" EXACT []
is_a: GO:0006952 ! defense response
is_a: GO:0009625 ! response to insect

[Term]
id: GO:0002215
name: defense response to nematode
namespace: biological_process
alt_id: GO:0002216
def: "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:add, PMID:11516579, PMID:14506883]
synonym: "physiological defense response to nematode" EXACT []
is_a: GO:0006952 ! defense response
is_a: GO:0009624 ! response to nematode

[Term]
id: GO:0002218
name: activation of innate immune response
namespace: biological_process
alt_id: GO:0002219
def: "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, GOC:mtg_sensu, ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:16177805]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002253 ! activation of immune response
is_a: GO:0045089 ! positive regulation of innate immune response

[Term]
id: GO:0002220
name: innate immune response activating cell surface receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967]
synonym: "activation of innate immune response by cell surface receptor signaling pathway" EXACT []
synonym: "innate immune response activating cell surface receptor signalling pathway" EXACT []
is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway
is_a: GO:0002758 ! innate immune response-activating signal transduction

[Term]
id: GO:0002221
name: pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967]
synonym: "PAMP receptor signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:15728447]
synonym: "pathogen receptor signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:15728447]
synonym: "pathogen receptor signalling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:15728447]
synonym: "PRR signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:15728447]
is_a: GO:0002758 ! innate immune response-activating signal transduction
is_a: GO:0023034 ! intracellular signaling pathway

[Term]
id: GO:0002222
name: stimulatory killer cell immunoglobulin-like receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
synonym: "stimulatory killer cell immunoglobulin-like receptor signalling pathway" EXACT []
synonym: "stimulatory KIR signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway

[Term]
id: GO:0002223
name: stimulatory C-type lectin receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
synonym: "stimulatory C-type lectin receptor signalling pathway" EXACT []
synonym: "stimulatory Ly49 family receptor signaling pathway." NARROW [ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway

[Term]
id: GO:0002224
name: toll-like receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology", PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
comment: This term was added by GO_REF:0000022. Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses.
synonym: "TLR signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology"]
synonym: "toll-like receptor signalling pathway" EXACT []
is_a: GO:0002221 ! pattern recognition receptor signaling pathway

[Term]
id: GO:0002225
name: positive regulation of antimicrobial peptide production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production." [GOC:add, PMID:11807545]
synonym: "activation of antimicrobial peptide production" NARROW []
synonym: "antimicrobial peptide induction" EXACT []
synonym: "stimulation of antimicrobial peptide production" NARROW []
synonym: "up regulation of antimicrobial peptide production" EXACT []
synonym: "up-regulation of antimicrobial peptide production" EXACT []
synonym: "upregulation of antimicrobial peptide production" EXACT []
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:0002784 ! regulation of antimicrobial peptide production
relationship: positively_regulates GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002227
name: innate immune response in mucosa
namespace: biological_process
def: "Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105]
is_a: GO:0002385 ! mucosal immune response
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0002228
name: natural killer cell mediated immunity
namespace: biological_process
def: "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
synonym: "NK cell mediated immunity" EXACT []
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0002229
name: defense response to oomycetes
namespace: biological_process
def: "Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism." [GOC:add, PMID:16497589]
is_a: GO:0002239 ! response to oomycetes
is_a: GO:0006952 ! defense response

[Term]
id: GO:0002230
name: positive regulation of defense response to virus by host
namespace: biological_process
def: "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of antiviral response by host" NARROW []
synonym: "positive regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of antiviral response by host" NARROW []
synonym: "up regulation of antiviral response by host" EXACT []
synonym: "up-regulation of antiviral response by host" EXACT []
synonym: "upregulation of antiviral response by host" EXACT []
is_a: GO:0050691 ! regulation of defense response to virus by host

[Term]
id: GO:0002231
name: detection of oomycetes
namespace: biological_process
def: "The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal." [GOC:add, PMID:15922649]
is_a: GO:0002239 ! response to oomycetes
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0002232
name: leukocyte chemotaxis during inflammatory response
namespace: biological_process
def: "The movement of an immune cell in response to an external stimulus during an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "immune cell chemotaxis during inflammatory response" EXACT []
synonym: "leucocyte chemotaxis during inflammatory response" EXACT []
is_a: GO:0002523 ! leukocyte migration during inflammatory response
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002233
name: leukocyte chemotaxis during immune response
namespace: biological_process
def: "The movement of an immune cell in response to an external stimulus during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "immune cell chemotaxis during immune response" EXACT []
synonym: "leucocyte chemotaxis during immune response" EXACT []
is_a: GO:0002522 ! leukocyte migration during immune response
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002234
name: detection of endoplasmic reticulum overloading
namespace: biological_process
def: "The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal." [GOC:add, PMID:10390516]
synonym: "detection of ER overloading" EXACT []
is_a: GO:0006983 ! ER overload response
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0002235
name: detection of unfolded protein
namespace: biological_process
def: "The series of events in which an unfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511, PMID:7765470]
is_a: GO:0006986 ! response to unfolded protein
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0002236
name: detection of misfolded protein
namespace: biological_process
def: "The series of events in which a misfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009595 ! detection of biotic stimulus
is_a: GO:0051788 ! response to misfolded protein

[Term]
id: GO:0002237
name: response to molecule of bacterial origin
namespace: biological_process
def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:rl, GOC:sm]
synonym: "response to bacteria associated molecule" EXACT []
synonym: "response to bacterial associated molecule" EXACT []
synonym: "response to bacterium associated molecule" EXACT []
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0010033 ! response to organic substance
relationship: part_of GO:0009617 ! response to bacterium

[Term]
id: GO:0002238
name: response to molecule of fungal origin
namespace: biological_process
def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:rl, GOC:sm]
synonym: "response to fungus associated molecule" EXACT []
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0010033 ! response to organic substance
relationship: part_of GO:0009620 ! response to fungus

[Term]
id: GO:0002239
name: response to oomycetes
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes." [GOC:add, PMID:16497589]
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0002240
name: response to molecule of oomycetes origin
namespace: biological_process
def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:rl, GOC:sm]
synonym: "response to oomycetes associated molecule" EXACT []
is_a: GO:0009607 ! response to biotic stimulus
relationship: part_of GO:0002239 ! response to oomycetes

[Term]
id: GO:0002241
name: response to parasitic plant
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant." [GOC:add, PMID:16547862]
is_a: GO:0009608 ! response to symbiont

[Term]
id: GO:0002242
name: defense response to parasitic plant
namespace: biological_process
def: "Reactions triggered in response to the presence of a parasitic plant that act to protect an organism." [GOC:add]
is_a: GO:0002241 ! response to parasitic plant
is_a: GO:0006952 ! defense response

[Term]
id: GO:0002243
name: detection of parasitic plant
namespace: biological_process
def: "The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal." [GOC:add, PMID:16547862]
is_a: GO:0002241 ! response to parasitic plant
is_a: GO:0009602 ! detection of symbiont

[Term]
id: GO:0002244
name: hemopoietic progenitor cell differentiation
namespace: biological_process
def: "The process whereby precursor cell type acquires the specialized features of a hemopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16551251]
synonym: "haematopoietic progenitor cell differentiation" EXACT []
synonym: "haemopoietic progenitor cell differentiation" EXACT []
synonym: "hematopoietic progenitor cell differentiation" RELATED []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0002246
name: healing during inflammatory response
namespace: biological_process
def: "The series of events that restore integrity to damaged tissue during or following an inflammatory response." [GOC:jal, ISBN:0721601871]
is_a: GO:0042060 ! wound healing
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002247
name: clearance of damaged tissue during inflammatory response
namespace: biological_process
def: "The series of events leading to removal of necrotic debris during or following an inflammatory response." [GOC:jal, ISBN:0721601871]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0002246 ! healing during inflammatory response

[Term]
id: GO:0002248
name: connective tissue replacement during inflammatory response
namespace: biological_process
def: "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared during or following an inflammatory response." [GOC:jal, ISBN:0721601871]
synonym: "fibrosis during inflammatory response" NARROW [ISBN:0721601871]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0002246 ! healing during inflammatory response

[Term]
id: GO:0002249
name: lymphocyte anergy
namespace: biological_process
def: "Any process contributing to lymphocyte anergy, a state of functional inactivation." [GOC:add]
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002250
name: adaptive immune response
namespace: biological_process
def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
synonym: "acquired immune response" EXACT [ISBN:068340007X "Stedman's Medical Dictionary"]
xref: Wikipedia:Adaptive_immune_system
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002251
name: organ or tissue specific immune response
namespace: biological_process
def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05]
comment: This term was added by GO_REF:0000022.
synonym: "immune response in organ or tissue" EXACT []
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002252
name: immune effector process
namespace: biological_process
def: "Any process of the immune system that occurs as part of an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002253
name: activation of immune response
namespace: biological_process
def: "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002376 ! immune system process
is_a: GO:0050778 ! positive regulation of immune response

[Term]
id: GO:0002254
name: kinin cascade
namespace: biological_process
def: "A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:jal, ISBN:0721601871, PMID:11842287, PMID:14501145]
is_a: GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002255
name: tissue kallikrein-kinin cascade
namespace: biological_process
def: "A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, PMID:11842287, PMID:14501145]
synonym: "glandular kallikrein-kinin cascade" EXACT []
is_a: GO:0002254 ! kinin cascade

[Term]
id: GO:0002256
name: regulation of kinin cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the kinin cascade." [GOC:jal]
is_a: GO:0002673 ! regulation of acute inflammatory response
relationship: regulates GO:0002254 ! kinin cascade

[Term]
id: GO:0002257
name: negative regulation of kinin cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate, or extent of the kinin cascade." [GOC:jal]
synonym: "down regulation of kinin cascade" EXACT []
synonym: "down-regulation of kinin cascade" EXACT []
synonym: "downregulation of kinin cascade" EXACT []
synonym: "inhibition of kinin cascade" NARROW []
is_a: GO:0002256 ! regulation of kinin cascade
is_a: GO:0002674 ! negative regulation of acute inflammatory response
relationship: negatively_regulates GO:0002254 ! kinin cascade

[Term]
id: GO:0002258
name: positive regulation of kinin cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the kinin cascade." [GOC:jal]
synonym: "activation of kinin cascade" NARROW []
synonym: "stimulation of kinin cascade" NARROW []
synonym: "up regulation of kinin cascade" EXACT []
synonym: "up-regulation of kinin cascade" EXACT []
synonym: "upregulation of kinin cascade" EXACT []
is_a: GO:0002256 ! regulation of kinin cascade
is_a: GO:0002675 ! positive regulation of acute inflammatory response
relationship: positively_regulates GO:0002254 ! kinin cascade

[Term]
id: GO:0002259
name: endothelial cell activation within high endothelial venule during immune response
namespace: biological_process
def: "A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002264 ! endothelial cell activation during immune response

[Term]
id: GO:0002260
name: lymphocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262]
is_a: GO:0001776 ! leukocyte homeostasis

[Term]
id: GO:0002261
name: mucosal lymphocyte homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15609020]
is_a: GO:0002260 ! lymphocyte homeostasis

[Term]
id: GO:0002262
name: myeloid cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add]
is_a: GO:0001776 ! leukocyte homeostasis

[Term]
id: GO:0002263
name: cell activation during immune response
namespace: biological_process
def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0001775 ! cell activation
relationship: part_of GO:0006955 ! immune response

[Term]
id: GO:0002264
name: endothelial cell activation during immune response
namespace: biological_process
def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002263 ! cell activation during immune response
is_a: GO:0042118 ! endothelial cell activation

[Term]
id: GO:0002265
name: astrocyte activation during immune response
namespace: biological_process
def: "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:11138785]
is_a: GO:0002263 ! cell activation during immune response
is_a: GO:0048143 ! astrocyte activation

[Term]
id: GO:0002266
name: follicular dendritic cell activation
namespace: biological_process
def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15606789]
is_a: GO:0001775 ! cell activation

[Term]
id: GO:0002267
name: follicular dendritic cell activation during immune response
namespace: biological_process
def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15606789]
is_a: GO:0002263 ! cell activation during immune response
is_a: GO:0002266 ! follicular dendritic cell activation

[Term]
id: GO:0002268
name: follicular dendritic cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002266 ! follicular dendritic cell activation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0002269
name: leukocyte activation during inflammatory response
namespace: biological_process
def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "immune cell activation during inflammatory response" EXACT []
is_a: GO:0045321 ! leukocyte activation
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002270
name: plasmacytoid dendritic cell activation
namespace: biological_process
def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15990333, PMID:16174109]
is_a: GO:0045321 ! leukocyte activation

[Term]
id: GO:0002271
name: plasmacytoid dendritic cell activation during immune response
namespace: biological_process
def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15990333, PMID:16174109]
is_a: GO:0002270 ! plasmacytoid dendritic cell activation
is_a: GO:0002366 ! leukocyte activation during immune response

[Term]
id: GO:0002272
name: plasmacytoid dendritic cell differentiation during immune response
namespace: biological_process
def: "The process whereby an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell during an immune response." [GOC:add, PMID:15990333]
is_a: GO:0002271 ! plasmacytoid dendritic cell activation during immune response
is_a: GO:0002273 ! plasmacytoid dendritic cell differentiation

[Term]
id: GO:0002273
name: plasmacytoid dendritic cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell." [GOC:add, PMID:15990333, PMID:16174108]
is_a: GO:0002270 ! plasmacytoid dendritic cell activation
is_a: GO:0002521 ! leukocyte differentiation

[Term]
id: GO:0002274
name: myeloid leukocyte activation
namespace: biological_process
def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "myeloid leucocyte activation" EXACT []
is_a: GO:0045321 ! leukocyte activation

[Term]
id: GO:0002275
name: myeloid cell activation during immune response
namespace: biological_process
def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002274 ! myeloid leukocyte activation
is_a: GO:0002366 ! leukocyte activation during immune response

[Term]
id: GO:0002276
name: basophil activation during immune response
namespace: biological_process
def: "A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002275 ! myeloid cell activation during immune response
is_a: GO:0045575 ! basophil activation

[Term]
id: GO:0002277
name: myeloid dendritic cell activation during immune response
namespace: biological_process
def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001773 ! myeloid dendritic cell activation
is_a: GO:0002275 ! myeloid cell activation during immune response

[Term]
id: GO:0002278
name: eosinophil activation during immune response
namespace: biological_process
def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002275 ! myeloid cell activation during immune response
is_a: GO:0043307 ! eosinophil activation

[Term]
id: GO:0002279
name: mast cell activation during immune response
namespace: biological_process
def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002275 ! myeloid cell activation during immune response
is_a: GO:0045576 ! mast cell activation

[Term]
id: GO:0002280
name: monocyte activation during immune response
namespace: biological_process
def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16551245]
is_a: GO:0002275 ! myeloid cell activation during immune response
is_a: GO:0042117 ! monocyte activation

[Term]
id: GO:0002281
name: macrophage activation during immune response
namespace: biological_process
def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002275 ! myeloid cell activation during immune response
is_a: GO:0042116 ! macrophage activation

[Term]
id: GO:0002282
name: microglial cell activation during immune response
namespace: biological_process
def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001774 ! microglial cell activation
is_a: GO:0002281 ! macrophage activation during immune response

[Term]
id: GO:0002283
name: neutrophil activation during immune response
namespace: biological_process
def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002275 ! myeloid cell activation during immune response
is_a: GO:0042119 ! neutrophil activation

[Term]
id: GO:0002284
name: myeloid dendritic cell differentiation during immune response
namespace: biological_process
def: "The process whereby an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002277 ! myeloid dendritic cell activation during immune response
is_a: GO:0043011 ! myeloid dendritic cell differentiation

[Term]
id: GO:0002285
name: lymphocyte activation during immune response
namespace: biological_process
def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002366 ! leukocyte activation during immune response
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0002286
name: T cell activation during immune response
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "T lymphocyte activation during immune response" EXACT []
synonym: "T-cell activation during immune response" EXACT []
synonym: "T-lymphocyte activation during immune response" EXACT []
is_a: GO:0002285 ! lymphocyte activation during immune response
is_a: GO:0042110 ! T cell activation

[Term]
id: GO:0002287
name: alpha-beta T cell activation during immune response
namespace: biological_process
def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "alpha-beta T lymphocyte activation during immune response" EXACT []
synonym: "alpha-beta T-cell activation during immune response" EXACT []
synonym: "alpha-beta T-lymphocyte activation during immune response" EXACT []
is_a: GO:0002286 ! T cell activation during immune response
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0002288
name: NK T cell activation during immune response
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15771592]
synonym: "natural killer T lymphocyte activation during immune response" EXACT []
synonym: "natural killer T-cell activation during immune response" EXACT []
synonym: "natural killer T-lymphocyte activation during immune response" EXACT []
synonym: "NK T lymphocyte activation during immune response" EXACT []
synonym: "NK T-cell activation during immune response" EXACT []
synonym: "NK T-lymphocyte activation during immune response" EXACT []
is_a: GO:0002287 ! alpha-beta T cell activation during immune response
is_a: GO:0051132 ! NK T cell activation

[Term]
id: GO:0002289
name: NK T cell proliferation during immune response
namespace: biological_process
def: "The expansion of a NK T cell population by cell division during an immune response." [GOC:add, PMID:15771592]
synonym: "natural killer T lymphocyte proliferation during immune response" EXACT []
synonym: "natural killer T-cell proliferation during immune response" EXACT []
synonym: "natural killer T-lymphocyte proliferation during immune response" EXACT []
synonym: "NK T lymphocyte proliferation during immune response" EXACT []
synonym: "NK T-cell proliferation during immune response" EXACT []
synonym: "NK T-lymphocyte proliferation during immune response" EXACT []
is_a: GO:0001866 ! NK T cell proliferation
is_a: GO:0002288 ! NK T cell activation during immune response
is_a: GO:0002310 ! alpha-beta T cell proliferation during immune response

[Term]
id: GO:0002290
name: gamma-delta T cell activation during immune response
namespace: biological_process
def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:8717523]
synonym: "gamma-delta T lymphocyte activation during immune response" EXACT []
synonym: "gamma-delta T-cell activation during immune response" EXACT []
synonym: "gamma-delta T-lymphocyte activation during immune response" EXACT []
is_a: GO:0002286 ! T cell activation during immune response
is_a: GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0002291
name: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT []
synonym: "T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT []
synonym: "T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT []
is_a: GO:0002286 ! T cell activation during immune response

[Term]
id: GO:0002292
name: T cell differentiation during immune response
namespace: biological_process
def: "The process whereby an antigenically nave T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "T lymphocyte differentiation during immune response" EXACT []
synonym: "T-cell differentiation during immune response" EXACT []
synonym: "T-lymphocyte differentiation during immune response" EXACT []
is_a: GO:0002286 ! T cell activation during immune response
is_a: GO:0030217 ! T cell differentiation

[Term]
id: GO:0002293
name: alpha-beta T cell differentiation during immune response
namespace: biological_process
def: "The process whereby an antigenically nave alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "alpha-beta T lymphocyte differentiation during immune response" EXACT []
synonym: "alpha-beta T-cell differentiation during immune response" EXACT []
synonym: "alpha-beta T-lymphocyte differentiation during immune response" EXACT []
is_a: GO:0002287 ! alpha-beta T cell activation during immune response
is_a: GO:0002292 ! T cell differentiation during immune response
is_a: GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0002294
name: CD4-positive, alpha-beta T cell differentiation during immune response
namespace: biological_process
def: "The process whereby an antigenically nave CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "CD4-positive, alpha-beta T lymphocyte differentiation during immune response" EXACT []
synonym: "CD4-positive, alpha-beta T-cell differentiation during immune response" EXACT []
synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation during immune response" EXACT []
is_a: GO:0002293 ! alpha-beta T cell differentiation during immune response
is_a: GO:0043367 ! CD4-positive, alpha beta T cell differentiation

[Term]
id: GO:0002295
name: T-helper cell lineage commitment
namespace: biological_process
def: "The process whereby a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "T-helper cell fate commitment" EXACT []
synonym: "Th0 lineage commitment" RELATED [ISBN:0781735149 "Fundamental Immunology"]
synonym: "Thp lineage commitment" RELATED [ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0042093 ! T-helper cell differentiation

[Term]
id: GO:0002296
name: T-helper 1 cell lineage commitment
namespace: biological_process
def: "The process whereby a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "T-helper 1 cell fate commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"]
synonym: "Th1 cell lineage commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"]
synonym: "Th1 fate commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002295 ! T-helper cell lineage commitment
relationship: part_of GO:0045063 ! T-helper 1 cell differentiation

[Term]
id: GO:0002297
name: T-helper 2 cell lineage commitment
namespace: biological_process
def: "The process whereby a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "T-helper 2 cell fate commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"]
synonym: "Th2 fate commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002295 ! T-helper cell lineage commitment
relationship: part_of GO:0045064 ! T-helper 2 cell differentiation

[Term]
id: GO:0002298
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response
namespace: biological_process
def: "The process whereby an antigenically nave CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell during an immune response." [GOC:add, PMID:12093005]
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" EXACT []
is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation during immune response
is_a: GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

[Term]
id: GO:0002299
name: alpha-beta intraepithelial T cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "alpha-beta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "alpha-beta intraepithelial T-cell differentiation" EXACT []
synonym: "alpha-beta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0002300
name: CD8-positive, alpha-beta intraepithelial T cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, alpha-beta intraepithelial T-cell differentiation" EXACT []
synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation
is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0002301
name: CD4-positive, alpha-beta intraepithelial T cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "CD4-positive, alpha-beta intraepithelial T-cell differentiation" EXACT []
synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation
is_a: GO:0043367 ! CD4-positive, alpha beta T cell differentiation

[Term]
id: GO:0002302
name: CD8-positive, alpha-beta T cell differentiation during immune response
namespace: biological_process
def: "The process whereby an antigenically nave CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "CD8-positive, alpha-beta T lymphocyte differentiation during immune response" EXACT []
synonym: "CD8-positive, alpha-beta T-cell differentiation during immune response" EXACT []
synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation during immune response" EXACT []
is_a: GO:0002293 ! alpha-beta T cell differentiation during immune response
is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0002303
name: gamma-delta T cell differentiation during immune response
namespace: biological_process
def: "The process whereby an antigenically nave gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add]
synonym: "gamma-delta T lymphocyte differentiation during immune response" EXACT []
synonym: "gamma-delta T-cell differentiation during immune response" EXACT []
synonym: "gamma-delta T-lymphocyte differentiation during immune response" EXACT []
is_a: GO:0002290 ! gamma-delta T cell activation during immune response
is_a: GO:0002292 ! T cell differentiation during immune response
is_a: GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0002304
name: gamma-delta intraepithelial T cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "gamma-delta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "gamma-delta intraepithelial T-cell differentiation" EXACT []
synonym: "gamma-delta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0002305
name: CD8-positive, gamma-delta intraepithelial T cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, gamma-delta intraepithelial T-cell differentiation" EXACT []
synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation

[Term]
id: GO:0002306
name: CD4-positive gamma-delta intraepithelial T cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT []
synonym: "CD4-positive, gamma-delta intraepithelial T-cell differentiation" EXACT []
synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT []
is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation

[Term]
id: GO:0002307
name: CD8-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "CD8-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation
is_a: GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0002308
name: CD8-positive, alpha-beta cytotoxic T cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, alpha-beta cytotoxic T-cell differentiation" EXACT []
synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation" EXACT []
is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation
is_a: GO:0045065 ! cytotoxic T cell differentiation

[Term]
id: GO:0002309
name: T cell proliferation during immune response
namespace: biological_process
def: "The expansion of a T cell population by cell division during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "T lymphocyte proliferation during immune response" EXACT []
synonym: "T-cell proliferation during immune response" EXACT []
synonym: "T-lymphocyte proliferation during immune response" EXACT []
is_a: GO:0002286 ! T cell activation during immune response
is_a: GO:0042098 ! T cell proliferation

[Term]
id: GO:0002310
name: alpha-beta T cell proliferation during immune response
namespace: biological_process
def: "The expansion of an alpha-beta T cell population by cell division during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "alpha-beta T lymphocyte proliferation during immune response" EXACT []
synonym: "alpha-beta T-cell proliferation during immune response" EXACT []
synonym: "alpha-beta T-lymphocyte proliferation during immune response" EXACT []
is_a: GO:0002287 ! alpha-beta T cell activation during immune response
is_a: GO:0002309 ! T cell proliferation during immune response
is_a: GO:0046633 ! alpha-beta T cell proliferation

[Term]
id: GO:0002311
name: gamma-delta T cell proliferation during immune response
namespace: biological_process
def: "The expansion of a gamma-delta T cell population by cell division during an immune response." [GOC:add]
synonym: "gamma-delta T lymphocyte proliferation during immune response" EXACT []
synonym: "gamma-delta T-cell proliferation during immune response" EXACT []
synonym: "gamma-delta T-lymphocyte proliferation during immune response" EXACT []
is_a: GO:0002290 ! gamma-delta T cell activation during immune response
is_a: GO:0002309 ! T cell proliferation during immune response
is_a: GO:0046630 ! gamma-delta T cell proliferation

[Term]
id: GO:0002312
name: B cell activation during immune response
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:jal]
synonym: "B lymphocyte activation during immune response" EXACT []
synonym: "B-cell activation during immune response" EXACT []
synonym: "B-lymphocyte activation during immune response" EXACT []
is_a: GO:0002285 ! lymphocyte activation during immune response
is_a: GO:0042113 ! B cell activation

[Term]
id: GO:0002313
name: mature B cell differentiation during immune response
namespace: biological_process
def: "The process whereby a nave B cell acquires the specialized features of a mature or memory B cell during an immune response." [GOC:jal]
synonym: "mature B lymphocyte differentiation during immune response" EXACT []
synonym: "mature B-cell differentiation during immune response" EXACT []
synonym: "mature B-lymphocyte differentiation during immune response" EXACT []
is_a: GO:0002312 ! B cell activation during immune response
is_a: GO:0002335 ! mature B cell differentiation

[Term]
id: GO:0002314
name: germinal center B cell differentiation
namespace: biological_process
def: "The process whereby a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "germinal center B lymphocyte differentiation" EXACT []
synonym: "germinal center B-cell differentiation" EXACT []
synonym: "germinal center B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation during immune response

[Term]
id: GO:0002315
name: marginal zone B cell differentiation
namespace: biological_process
def: "The process whereby a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "marginal zone B lymphocyte differentiation" EXACT []
synonym: "marginal zone B-cell differentiation" EXACT []
synonym: "marginal zone B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation during immune response

[Term]
id: GO:0002316
name: follicular B cell differentiation
namespace: biological_process
def: "The process whereby a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "follicular B lymphocyte differentiation" EXACT []
synonym: "follicular B-cell differentiation" EXACT []
synonym: "follicular B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation during immune response

[Term]
id: GO:0002317
name: plasma cell differentiation
namespace: biological_process
def: "The process whereby a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody." [GOC:jal]
is_a: GO:0002313 ! mature B cell differentiation during immune response

[Term]
id: GO:0002318
name: myeloid progenitor cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264]
is_a: GO:0002244 ! hemopoietic progenitor cell differentiation

[Term]
id: GO:0002319
name: memory B cell differentiation
namespace: biological_process
def: "The process whereby a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "memory B lymphocyte differentiation" EXACT []
synonym: "memory B-cell differentiation" EXACT []
synonym: "memory B-lymphocyte differentiation" EXACT []
is_a: GO:0002313 ! mature B cell differentiation during immune response

[Term]
id: GO:0002320
name: lymphoid progenitor cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264]
is_a: GO:0002244 ! hemopoietic progenitor cell differentiation

[Term]
id: GO:0002321
name: natural killer cell progenitor differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a natural killer cell progenitor." [GOC:add, PMID:16551251, PMID:16551264]
is_a: GO:0002320 ! lymphoid progenitor cell differentiation

[Term]
id: GO:0002322
name: B cell proliferation during immune response
namespace: biological_process
def: "The expansion of a B cell population by cell division following B cell activation during an immune response." [GOC:jal]
synonym: "B lymphocyte proliferation during immune response" EXACT []
synonym: "B-cell proliferation during immune response" EXACT []
synonym: "B-lymphocyte proliferation during immune response" EXACT []
is_a: GO:0002312 ! B cell activation during immune response
is_a: GO:0042100 ! B cell proliferation

[Term]
id: GO:0002323
name: natural killer cell activation during immune response
namespace: biological_process
def: "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15032583]
synonym: "NK cell activation during immune response" EXACT []
is_a: GO:0002285 ! lymphocyte activation during immune response
is_a: GO:0030101 ! natural killer cell activation

[Term]
id: GO:0002324
name: natural killer cell proliferation during immune response
namespace: biological_process
def: "The expansion of a natural killer cell population by cell division during an immune response." [GOC:add, PMID:15032583]
synonym: "NK cell proliferation during immune response" EXACT []
is_a: GO:0001787 ! natural killer cell proliferation
is_a: GO:0002323 ! natural killer cell activation during immune response

[Term]
id: GO:0002325
name: natural killer cell differentiation during immune response
namespace: biological_process
def: "The process whereby a nave natural killer cell acquires the specialized features of an effector natural killer T cell during an immune response." [GOC:add, PMID:11698225]
synonym: "NK cell differentiation during immune response" EXACT []
is_a: GO:0001779 ! natural killer cell differentiation
is_a: GO:0002323 ! natural killer cell activation during immune response

[Term]
id: GO:0002326
name: B cell lineage commitment
namespace: biological_process
def: "The process whereby a lymphoid progenitor cell becomes committed to become any type of B cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "B lymphocyte lineage commitment" EXACT []
synonym: "B-cell lineage commitment" EXACT []
synonym: "B-lymphocyte lineage commitment" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0030183 ! B cell differentiation

[Term]
id: GO:0002327
name: immature B cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of an immature B cell." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16551251]
synonym: "immature B lymphocyte differentiation" EXACT []
synonym: "immature B-cell differentiation" EXACT []
synonym: "immature B-lymphocyte differentiation" EXACT []
is_a: GO:0030183 ! B cell differentiation

[Term]
id: GO:0002328
name: pro-B cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "pro-B lymphocyte differentiation" EXACT []
is_a: GO:0002320 ! lymphoid progenitor cell differentiation

[Term]
id: GO:0002329
name: pre-B cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "pre-B lymphocyte differentiation" EXACT []
is_a: GO:0002327 ! immature B cell differentiation

[Term]
id: GO:0002330
name: pre-B cell receptor expression
namespace: biological_process
def: "The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, including expression of the surrogate light chain, association of the surrogate light chain with heavy chain, and expression of the complete pre-B cell receptor on the cell surface." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002329 ! pre-B cell differentiation

[Term]
id: GO:0002331
name: pre-B cell allelic exclusion
namespace: biological_process
def: "Expression of a single heavy chain allele during pre-B cell differentiation." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "pre-B lymphocyte allelic exclusion" EXACT []
is_a: GO:0002329 ! pre-B cell differentiation

[Term]
id: GO:0002332
name: transitional stage B cell differentiation
namespace: biological_process
def: "The process whereby immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "transitional stage B lymphocyte differentiation" EXACT []
synonym: "transitional stage B-cell differentiation" EXACT []
synonym: "transitional stage B-lymphocyte differentiation" EXACT []
is_a: GO:0002327 ! immature B cell differentiation

[Term]
id: GO:0002333
name: transitional one stage B cell differentiation
namespace: biological_process
def: "The process whereby immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "T1 stage B cell differentiation" EXACT []
synonym: "transitional one stage B lymphocyte differentiation" EXACT []
synonym: "transitional one stage B-cell differentiation" EXACT []
synonym: "transitional one stage B-lymphocyte differentiation" EXACT []
is_a: GO:0002332 ! transitional stage B cell differentiation

[Term]
id: GO:0002334
name: transitional two stage B cell differentiation
namespace: biological_process
def: "The process whereby immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "T2 stage B cell differentiation" EXACT []
synonym: "transitional two stage B lymphocyte differentiation" EXACT []
synonym: "transitional two stage B-cell differentiation" EXACT []
synonym: "transitional two stage B-lymphocyte differentiation" EXACT []
is_a: GO:0002332 ! transitional stage B cell differentiation

[Term]
id: GO:0002335
name: mature B cell differentiation
namespace: biological_process
def: "The process whereby transitional stage B cells acquire the specialized features of mature B cells in the spleen." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "mature B lymphocyte differentiation" EXACT []
synonym: "mature B-cell differentiation" EXACT []
synonym: "mature B-lymphocyte differentiation" EXACT []
is_a: GO:0030183 ! B cell differentiation

[Term]
id: GO:0002336
name: B-1 B cell lineage commitment
namespace: biological_process
def: "The process by which an immature B cell becomes committed to become a B-1 B cell." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "B-1 B lymphocyte lineage commitment" EXACT []
synonym: "B-1 B-cell lineage commitment" EXACT []
synonym: "B-1 B-lymphocyte lineage commitment" EXACT []
is_a: GO:0002326 ! B cell lineage commitment
relationship: part_of GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0002337
name: B-1a B cell differentiation
namespace: biological_process
def: "The process whereby B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "B-1a B lymphocyte differentiation" EXACT []
synonym: "B-1a B-cell differentiation" EXACT []
synonym: "B-1a B-lymphocyte differentiation" EXACT []
is_a: GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0002338
name: B-1b B cell differentiation
namespace: biological_process
def: "The process whereby B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "B-1b B lymphocyte differentiation" EXACT []
synonym: "B-1b B-cell differentiation" EXACT []
synonym: "B-1b B-lymphocyte differentiation" EXACT []
is_a: GO:0001923 ! B-1 B cell differentiation

[Term]
id: GO:0002339
name: B cell selection
namespace: biological_process
def: "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival." [GOC:jal]
synonym: "B lymphocyte selection" EXACT []
synonym: "B-cell selection" EXACT []
synonym: "B-lymphocyte selection" EXACT []
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0030183 ! B cell differentiation

[Term]
id: GO:0002340
name: central B cell selection
namespace: biological_process
def: "Any B cell selection process that occurs in the bone marrow." [GOC:jal]
synonym: "central B lymphocyte selection" EXACT []
synonym: "central B-cell selection" EXACT []
synonym: "central B-lymphocyte selection" EXACT []
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002341
name: central B cell anergy
namespace: biological_process
def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow." [GOC:jal]
synonym: "central B lymphocyte anergy" EXACT []
synonym: "central B-cell anergy" EXACT []
synonym: "central B-lymphocyte anergy" EXACT []
is_a: GO:0002515 ! B cell anergy
relationship: part_of GO:0002340 ! central B cell selection
relationship: part_of GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002342
name: central B cell deletion
namespace: biological_process
def: "The deletion of B cells by apoptosis occurring as part of central tolerance induction and B cell selection." [GOC:add, GOC:jal]
synonym: "central B lymphocyte deletion" EXACT []
synonym: "central B-cell deletion" EXACT []
synonym: "central B-lymphocyte deletion" EXACT []
is_a: GO:0002516 ! B cell deletion
relationship: part_of GO:0002340 ! central B cell selection
relationship: part_of GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002343
name: peripheral B cell selection
namespace: biological_process
def: "Any B cell selection process that occurs in the periphery." [GOC:jal]
synonym: "peripheral B lymphocyte selection" EXACT []
synonym: "peripheral B-cell selection" EXACT []
synonym: "peripheral B-lymphocyte selection" EXACT []
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002344
name: B cell affinity maturation
namespace: biological_process
def: "The process by which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
synonym: "B lymphocyte affinity maturation" EXACT []
synonym: "B-cell affinity maturation" EXACT []
synonym: "B-lymphocyte affinity maturation" EXACT []
is_a: GO:0002343 ! peripheral B cell selection
relationship: part_of GO:0002381 ! immunoglobulin production during immune response

[Term]
id: GO:0002345
name: peripheral B cell receptor editing
namespace: biological_process
def: "The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation." [GOC:jal]
synonym: "peripheral B lymphocyte receptor editing" EXACT []
synonym: "peripheral B-cell receptor editing" EXACT []
synonym: "peripheral B-lymphocyte receptor editing" EXACT []
is_a: GO:0002452 ! B cell receptor editing

[Term]
id: GO:0002346
name: B cell positive selection
namespace: biological_process
def: "Any process by which B cells are selected to survive based on signaling through the B cell antigen receptor." [GOC:jal]
synonym: "B lymphocyte positive selection" EXACT []
synonym: "B-cell positive selection" EXACT []
synonym: "B-lymphocyte positive selection" EXACT []
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002347
name: response to tumor cell
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260]
is_a: GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002348
name: central B cell positive selection
namespace: biological_process
def: "Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process by which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal]
synonym: "central B lymphocyte positive selection" EXACT []
synonym: "central B-cell positive selection" EXACT []
synonym: "central B-lymphocyte positive selection" EXACT []
is_a: GO:0002340 ! central B cell selection
is_a: GO:0002346 ! B cell positive selection

[Term]
id: GO:0002349
name: histamine production during acute inflammatory response
namespace: biological_process
def: "The synthesis or release of histamine following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260]
is_a: GO:0002532 ! production of molecular mediator of acute inflammatory response

[Term]
id: GO:0002350
name: peripheral B cell positive selection
namespace: biological_process
def: "Any process leading to positive selection of B cells in the periphery. Positive selection is the process by which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal]
synonym: "peripheral B lymphocyte positive selection" EXACT []
synonym: "peripheral B-cell positive selection" EXACT []
synonym: "peripheral B-lymphocyte positive selection" EXACT []
is_a: GO:0002343 ! peripheral B cell selection
is_a: GO:0002346 ! B cell positive selection

[Term]
id: GO:0002351
name: serotonin production during acute inflammatory response
namespace: biological_process
def: "The synthesis or release of serotonin following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260]
is_a: GO:0002532 ! production of molecular mediator of acute inflammatory response

[Term]
id: GO:0002352
name: B cell negative selection
namespace: biological_process
def: "Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion." [GOC:jal]
synonym: "B lymphocyte negative selection" EXACT []
synonym: "B-cell negative selection" EXACT []
synonym: "B-lymphocyte negative selection" EXACT []
is_a: GO:0002339 ! B cell selection

[Term]
id: GO:0002353
name: plasma kallikrein-kinin cascade
namespace: biological_process
def: "A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, ISBN:0721601871, PMID:11842287, PMID:14501145]
is_a: GO:0002254 ! kinin cascade

[Term]
id: GO:0002354
name: central B cell negative selection
namespace: biological_process
def: "Any process leading to negative selection of B cells in the bone marrow." [GOC:jal]
synonym: "central B lymphocyte negative selection" EXACT []
synonym: "central B-cell negative selection" EXACT []
synonym: "central B-lymphocyte negative selection" EXACT []
is_a: GO:0002340 ! central B cell selection
is_a: GO:0002352 ! B cell negative selection

[Term]
id: GO:0002355
name: detection of tumor cell
namespace: biological_process
def: "The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260]
is_a: GO:0002347 ! response to tumor cell
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0002356
name: peripheral B cell negative selection
namespace: biological_process
def: "Any process leading to negative selection of B cells in the periphery." [GOC:jal]
synonym: "peripheral B lymphocyte negative selection" EXACT []
synonym: "peripheral B-cell negative selection" EXACT []
synonym: "peripheral B-lymphocyte negative selection" EXACT []
is_a: GO:0002343 ! peripheral B cell selection
is_a: GO:0002352 ! B cell negative selection

[Term]
id: GO:0002357
name: defense response to tumor cell
namespace: biological_process
def: "Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260]
is_a: GO:0002347 ! response to tumor cell
is_a: GO:0006952 ! defense response

[Term]
id: GO:0002358
name: B cell homeostatic proliferation
namespace: biological_process
def: "The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus." [GOC:jal]
synonym: "B lymphocyte homeostatic proliferation" EXACT []
synonym: "B-cell homeostatic proliferation" EXACT []
synonym: "B-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042100 ! B cell proliferation

[Term]
id: GO:0002359
name: B-1 B cell proliferation
namespace: biological_process
def: "The expansion of a B-1 B cell by cell division. Follows B cell activation." [GOC:jal]
synonym: "B-1 B lymphocyte proliferation" EXACT []
synonym: "B-1 B-cell proliferation" EXACT []
synonym: "B-1 B-lymphocyte proliferation" EXACT []
is_a: GO:0042100 ! B cell proliferation

[Term]
id: GO:0002360
name: T cell lineage commitment
namespace: biological_process
def: "The process by which a lymphoid progenitor cell becomes committed to becoming any type of T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "T lymphocyte lineage commitment" EXACT []
synonym: "T-cell lineage commitment" EXACT []
synonym: "T-lymphocyte lineage commitment" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0030217 ! T cell differentiation

[Term]
id: GO:0002361
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821]
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
is_a: GO:0043367 ! CD4-positive, alpha beta T cell differentiation
is_a: GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0002362
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
namespace: biological_process
def: "The process by which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821]
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment" EXACT []
synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

[Term]
id: GO:0002363
name: alpha-beta T cell lineage commitment
namespace: biological_process
def: "The process by which a pro-T cell becomes committed to becoming an alpha-beta T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "alpha-beta T lymphocyte lineage commitment" EXACT []
synonym: "alpha-beta T-cell lineage commitment" EXACT []
synonym: "alpha-beta T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0002364
name: NK T cell lineage commitment
namespace: biological_process
def: "The process by which a pro-T cell becomes committed to becoming an NK T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "natural killer T lymphocyte lineage commitment" EXACT []
synonym: "natural killer T-cell lineage commitment" EXACT []
synonym: "natural killer T-lymphocyte lineage commitment" EXACT []
synonym: "NK T lymphocyte lineage commitment" EXACT []
synonym: "NK T-cell lineage commitment" EXACT []
synonym: "NK T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0001865 ! NK T cell differentiation

[Term]
id: GO:0002365
name: gamma-delta T cell lineage commitment
namespace: biological_process
def: "The process by which a pro-T cell becomes committed to becoming a gamma-delta T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "gamma-delta T lymphocyte lineage commitment" EXACT []
synonym: "gamma-delta T-cell lineage commitment" EXACT []
synonym: "gamma-delta T-lymphocyte lineage commitment" EXACT []
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0002366
name: leukocyte activation during immune response
namespace: biological_process
def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "immune cell activation during immune response" EXACT []
synonym: "leucocyte activation during immune response" EXACT []
is_a: GO:0002263 ! cell activation during immune response
is_a: GO:0045321 ! leukocyte activation

[Term]
id: GO:0002367
name: cytokine production during immune response
namespace: biological_process
def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022. Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules.
is_a: GO:0001816 ! cytokine production
is_a: GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002368
name: B cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a B cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "B lymphocyte cytokine production" EXACT []
synonym: "B-cell cytokine production" EXACT []
synonym: "B-lymphocyte cytokine production" EXACT []
is_a: GO:0002367 ! cytokine production during immune response
is_a: GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002369
name: T cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "T lymphocyte cytokine production" EXACT []
synonym: "T-cell cytokine production" EXACT []
synonym: "T-lymphocyte cytokine production" EXACT []
is_a: GO:0002367 ! cytokine production during immune response
is_a: GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002370
name: natural killer cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a natural killer cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "NK cell cytokine production" EXACT []
is_a: GO:0002228 ! natural killer cell mediated immunity
is_a: GO:0002367 ! cytokine production during immune response

[Term]
id: GO:0002371
name: dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002367 ! cytokine production during immune response

[Term]
id: GO:0002372
name: myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002373
name: plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a plasmacytoid dendritic cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002374
name: cytokine secretion during immune response
namespace: biological_process
def: "The regulated release of cytokines from a cell or group of cells during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0002367 ! cytokine production during immune response

[Term]
id: GO:0002375
name: cytokine biosynthetic process during immune response
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cytokine during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0002367 ! cytokine production during immune response

[Term]
id: GO:0002376
name: immune system process
namespace: biological_process
def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). This term was added by GO_REF:0000022.
subset: goslim_pir
xref: Wikipedia:Immune_syntem
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0002377
name: immunoglobulin production
namespace: biological_process
def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "antibody production" EXACT []
is_a: GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002378
name: immunoglobulin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of immunoglobulin." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "antibody biosynthesis" EXACT []
synonym: "antibody biosynthetic process" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
relationship: part_of GO:0002377 ! immunoglobulin production

[Term]
id: GO:0002379
name: immunoglobulin biosynthetic process during immune response
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of immunoglobulin during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "antibody biosynthesis during immune response" EXACT []
synonym: "antibody biosynthetic process during immune response" EXACT []
is_a: GO:0002378 ! immunoglobulin biosynthetic process
relationship: part_of GO:0002381 ! immunoglobulin production during immune response

[Term]
id: GO:0002380
name: immunoglobulin secretion during immune response
namespace: biological_process
def: "The regulated release of immunoglobulins from a B cell or plasma cell during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:9185563]
synonym: "antibody secretion during immune response" EXACT []
is_a: GO:0048305 ! immunoglobulin secretion
relationship: part_of GO:0002381 ! immunoglobulin production during immune response

[Term]
id: GO:0002381
name: immunoglobulin production during immune response
namespace: biological_process
def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "antibody production during immune response" EXACT []
is_a: GO:0002377 ! immunoglobulin production
relationship: part_of GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002382
name: regulation of tissue kallikrein-kinin cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add]
synonym: "regulation of glandular kallikrein-kinin cascade" EXACT []
is_a: GO:0002256 ! regulation of kinin cascade
relationship: regulates GO:0002255 ! tissue kallikrein-kinin cascade

[Term]
id: GO:0002383
name: immune response in brain or nervous system
namespace: biological_process
def: "An immune response taking place in the brain or nervous system." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002251 ! organ or tissue specific immune response

[Term]
id: GO:0002384
name: hepatic immune response
namespace: biological_process
def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002251 ! organ or tissue specific immune response

[Term]
id: GO:0002385
name: mucosal immune response
namespace: biological_process
def: "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002251 ! organ or tissue specific immune response

[Term]
id: GO:0002386
name: immune response in mucosal-associated lymphoid tissue
namespace: biological_process
def: "Immune response taking place in the mucosal-associated lymphoid tissue (MALT). Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "immune response in MALT" EXACT []
is_a: GO:0002385 ! mucosal immune response

[Term]
id: GO:0002387
name: immune response in gut-associated lymphoid tissue
namespace: biological_process
def: "Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "immune response in GALT" EXACT []
is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue

[Term]
id: GO:0002388
name: immune response in Peyer's patch
namespace: biological_process
def: "Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue

[Term]
id: GO:0002389
name: tolerance induction in Peyer's patch
namespace: biological_process
def: "Tolerance induction taking place in the Peyer's patches." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002388 ! immune response in Peyer's patch
is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue

[Term]
id: GO:0002390
name: platelet activating factor production
namespace: biological_process
def: "The synthesis or release of platelet activating factor following a stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0002391
name: platelet activating factor production during acute inflammatory response
namespace: biological_process
def: "The synthesis or release of platelet activating factor following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002390 ! platelet activating factor production
is_a: GO:0002534 ! cytokine production during acute inflammatory response

[Term]
id: GO:0002392
name: platelet activating factor secretion
namespace: biological_process
def: "The regulated release of platelet activating factor by a cell or group of cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0050663 ! cytokine secretion

[Term]
id: GO:0002393
name: production of lysosomal enzymes during acute inflammatory response
namespace: biological_process
def: "The synthesis or release of lysosomal enzymes following a stimulus during an acute inflammatory response, resulting in an increase in intracellular or extracellular levels." [GOC:add]
is_a: GO:0002532 ! production of molecular mediator of acute inflammatory response

[Term]
id: GO:0002394
name: tolerance induction in gut-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the gut-associated lymphoid tissue (GALT)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "oral tolerance" RELATED []
synonym: "tolerance induction in GALT" EXACT []
is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue
is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue

[Term]
id: GO:0002395
name: immune response in nasopharyngeal-associated lymphoid tissue
namespace: biological_process
def: "An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "immune response in NALT" EXACT []
is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue

[Term]
id: GO:0002396
name: MHC protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591, PMID:15928678]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0002397
name: MHC class I protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
is_a: GO:0002396 ! MHC protein complex assembly

[Term]
id: GO:0002398
name: MHC class Ib protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules." [GOC:add, PMID:15928678, PMID:15928680]
is_a: GO:0002396 ! MHC protein complex assembly

[Term]
id: GO:0002399
name: MHC class II protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
is_a: GO:0002396 ! MHC protein complex assembly

[Term]
id: GO:0002400
name: tolerance induction in nasopharyngeal-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "nasal tolerance" RELATED []
synonym: "tolerance induction in NALT" EXACT []
is_a: GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue
is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue

[Term]
id: GO:0002401
name: tolerance induction in mucosal-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "tolerance induction in MALT" EXACT []
is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue
is_a: GO:0002427 ! mucosal tolerance induction

[Term]
id: GO:0002402
name: B cell tolerance induction in mucosal-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "B cell tolerance induction in MALT" EXACT []
is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue
is_a: GO:0002451 ! peripheral B cell tolerance induction

[Term]
id: GO:0002403
name: T cell tolerance induction in mucosal-associated lymphoid tissue
namespace: biological_process
def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16551263]
synonym: "T cell tolerance induction in MALT" EXACT []
is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue
is_a: GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002404
name: antigen sampling in mucosal-associated lymphoid tissue
namespace: biological_process
def: "The process initiating the mucosal immune response which entails the apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:12843411, PMID:15681746]
synonym: "antigen sampling in MALT" EXACT []
synonym: "antigen transport in MALT" RELATED []
synonym: "antigen transport in mucosal-associated lymphoid tissue" RELATED []
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue

[Term]
id: GO:0002405
name: antigen sampling by dendritic cells in mucosal-associated lymphoid tissue
namespace: biological_process
def: "The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:15681746]
synonym: "antigen sampling by dendritic cells in MALT" EXACT []
is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue
relationship: part_of GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002406
name: antigen sampling by M cells in mucosal-associated lymphoid tissue
namespace: biological_process
def: "The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763]
synonym: "antigen sampling by M cells in MALT" EXACT []
is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue

[Term]
id: GO:0002407
name: dendritic cell chemotaxis
namespace: biological_process
def: "The movement of a dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15814331, PMID:16056255]
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002408
name: myeloid dendritic cell chemotaxis
namespace: biological_process
def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15814331, PMID:16056255]
is_a: GO:0002407 ! dendritic cell chemotaxis

[Term]
id: GO:0002409
name: Langerhans cell chemotaxis
namespace: biological_process
def: "The movement of a Langerhans cell in response to an external stimulus." [GOC:add, PMID:16056255, PMID:16387601]
is_a: GO:0002408 ! myeloid dendritic cell chemotaxis

[Term]
id: GO:0002410
name: plasmacytoid dendritic cell chemotaxis
namespace: biological_process
def: "The movement of a plasmacytoid dendritic cell in response to an external stimulus." [GOC:add, PMID:15159375, PMID:15814331]
is_a: GO:0002407 ! dendritic cell chemotaxis

[Term]
id: GO:0002411
name: T cell tolerance induction to tumor cell
namespace: biological_process
def: "A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260]
is_a: GO:0002413 ! tolerance induction to tumor cell
is_a: GO:0002424 ! T cell mediated immune response to tumor cell
is_a: GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002412
name: antigen transcytosis by M cells in mucosal-associated lymphoid tissue
namespace: biological_process
def: "The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:12843411]
synonym: "antigen transcytosis by M cells in MALT" EXACT []
synonym: "antigen transport by M cells in MALT" EXACT []
synonym: "antigen transport by M cells in mucosal-associated lymphoid tissue" EXACT []
is_a: GO:0045056 ! transcytosis
relationship: part_of GO:0002406 ! antigen sampling by M cells in mucosal-associated lymphoid tissue

[Term]
id: GO:0002413
name: tolerance induction to tumor cell
namespace: biological_process
def: "A process of tolerance induction which leads to immunological tolerance of a tumor." [GOC:add]
is_a: GO:0002418 ! immune response to tumor cell
is_a: GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002414
name: immunoglobulin transcytosis in epithelial cells
namespace: biological_process
def: "The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other." [GOC:add, ISBN:0781735149 "Fundamental Immunology", ISBN:081533642X, PMID:16048543]
is_a: GO:0045056 ! transcytosis

[Term]
id: GO:0002415
name: immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
namespace: biological_process
def: "The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa." [GOC:add, ISBN:0781735149 "Fundamental Immunology", ISBN:081533642X, PMID:16048543]
synonym: "antibody transcytosis mediated by pIgR" EXACT []
synonym: "immunoglobulin transcytosis mediated by pIgR" EXACT []
is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells
relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue

[Term]
id: GO:0002416
name: IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
namespace: biological_process
def: "The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals." [GOC:add, ISBN:0781735149 "Fundamental Immunology", ISBN:081533642X]
synonym: "IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor" EXACT []
synonym: "IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor" EXACT []
is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells

[Term]
id: GO:0002417
name: B cell antigen processing and presentation mediated by B cell receptor uptake of antigen
namespace: biological_process
def: "B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
synonym: "B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT []
synonym: "B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT []
synonym: "B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT []
is_a: GO:0002450 ! B cell antigen processing and presentation
is_a: GO:0002751 ! antigen processing and presentation following receptor mediated endocytosis

[Term]
id: GO:0002418
name: immune response to tumor cell
namespace: biological_process
def: "An immune system process that functions in the response of an organism to a tumor cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260]
is_a: GO:0002347 ! response to tumor cell
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002419
name: T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260]
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
synonym: "T lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "T-cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "T-lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT []
is_a: GO:0001913 ! T cell mediated cytotoxicity
is_a: GO:0002424 ! T cell mediated immune response to tumor cell

[Term]
id: GO:0002420
name: natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260]
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
synonym: "NK cell mediated cytotoxicity directed against tumor cell target" EXACT []
is_a: GO:0002423 ! natural killer cell mediated immune response to tumor cell
is_a: GO:0042267 ! natural killer cell mediated cytotoxicity

[Term]
id: GO:0002421
name: B cell antigen processing and presentation following pinocytosis
namespace: biological_process
def: "B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, PMID:7543530]
synonym: "B lymphocyte antigen processing and presentation following pinocytosis" EXACT []
synonym: "B-cell antigen processing and presentation following pinocytosis" EXACT []
synonym: "B-lymphocyte antigen processing and presentation following pinocytosis" EXACT []
is_a: GO:0002450 ! B cell antigen processing and presentation
is_a: GO:0002746 ! antigen processing and presentation following pinocytosis

[Term]
id: GO:0002422
name: immune response in urogenital tract
namespace: biological_process
def: "An immune response taking place in the urogenital tract. The urogenital tract." [GOC:jal]
is_a: GO:0002385 ! mucosal immune response

[Term]
id: GO:0002423
name: natural killer cell mediated immune response to tumor cell
namespace: biological_process
def: "An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260]
is_a: GO:0002228 ! natural killer cell mediated immunity
is_a: GO:0002418 ! immune response to tumor cell

[Term]
id: GO:0002424
name: T cell mediated immune response to tumor cell
namespace: biological_process
def: "An immune response mediated by a T cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260]
comment: Note that this term includes tolerogenic responses to tumor cells mediated by responding T cells.
is_a: GO:0002418 ! immune response to tumor cell
is_a: GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002425
name: tolerance induction in urogenital tract
namespace: biological_process
def: "Tolerance induction taking place in the urogenital tract." [GOC:jal]
is_a: GO:0002422 ! immune response in urogenital tract
is_a: GO:0002427 ! mucosal tolerance induction

[Term]
id: GO:0002426
name: immunoglobulin production in mucosal tissue
namespace: biological_process
def: "The synthesis and release of immunoglobulin in the mucosal tissue." [GOC:jal]
synonym: "antibody production in mucosal tissue " EXACT []
is_a: GO:0002381 ! immunoglobulin production during immune response
relationship: part_of GO:0002385 ! mucosal immune response

[Term]
id: GO:0002427
name: mucosal tolerance induction
namespace: biological_process
def: "Tolerance induction taking place in the mucosal tissues." [GOC:jal]
is_a: GO:0002385 ! mucosal immune response
is_a: GO:0002462 ! tolerance induction to nonself antigen

[Term]
id: GO:0002428
name: antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family." [GOC:add, PMID:15928678]
synonym: "peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002429
name: immune response-activating cell surface receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
synonym: "activation of immune response by cell surface receptor signaling pathway" EXACT []
synonym: "immune response-activating cell surface receptor signalling pathway" EXACT []
is_a: GO:0002757 ! immune response-activating signal transduction
is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway

[Term]
id: GO:0002430
name: complement receptor mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
synonym: "complement receptor mediated signalling pathway" EXACT []
synonym: "immune response-regulating cell surface receptor signalling pathway" BROAD []
is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway

[Term]
id: GO:0002431
name: Fc receptor mediated stimulatory signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
synonym: "Fc receptor mediated stimulatory signalling pathway" EXACT []
synonym: "Fc-receptor mediated stimulatory signaling pathway" EXACT []
is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway

[Term]
id: GO:0002432
name: granuloma formation
namespace: biological_process
def: "The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X "Stedman's Medical Dictionary", ISBN:0721601464, ISBN:081533642X]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002252 ! immune effector process
relationship: part_of GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002433
name: phagocytosis triggered by activation of immune response cell surface activating receptor
namespace: biological_process
def: "Phagocytosis occurring as the result of a ligand binding an immune response cell surface activating receptor." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002252 ! immune effector process
is_a: GO:0006909 ! phagocytosis

[Term]
id: GO:0002434
name: immune complex clearance
namespace: biological_process
def: "A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X "Stedman's Medical Dictionary"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0002435
name: immune complex clearance by erythrocytes
namespace: biological_process
def: "The process of immune complex clearance by erythrocytes." [GOC:add, PMID:11414352]
synonym: "immune complex clearance by RBCs" EXACT [CL:0000232]
synonym: "immune complex clearance by red blood cells" EXACT [CL:0000232]
is_a: GO:0002434 ! immune complex clearance

[Term]
id: GO:0002436
name: immune complex clearance by monocytes and macrophages
namespace: biological_process
def: "The process of immune complex clearance by monocytes or macrophages." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002434 ! immune complex clearance

[Term]
id: GO:0002437
name: inflammatory response to antigenic stimulus
namespace: biological_process
def: "An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0006954 ! inflammatory response
is_a: GO:0006955 ! immune response

[Term]
id: GO:0002438
name: acute inflammatory response to antigenic stimulus
namespace: biological_process
def: "An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002437 ! inflammatory response to antigenic stimulus
is_a: GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002439
name: chronic inflammatory response to antigenic stimulus
namespace: biological_process
def: "A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002437 ! inflammatory response to antigenic stimulus
is_a: GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002440
name: production of molecular mediator of immune response
namespace: biological_process
def: "The synthesis or release of any molecular mediator of the immune response following an immunological stimulus, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
synonym: "production of cellular mediator of immune response" RELATED []
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0002441
name: histamine secretion during acute inflammatory response
namespace: biological_process
def: "The regulated release of histamine by a cell or group of cells during an acute inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001821 ! histamine secretion
is_a: GO:0046879 ! hormone secretion
relationship: part_of GO:0002349 ! histamine production during acute inflammatory response

[Term]
id: GO:0002442
name: serotonin secretion during acute inflammatory response
namespace: biological_process
def: "The regulated release of serotonin by a cell or group of cells during an acute inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001820 ! serotonin secretion
relationship: part_of GO:0002351 ! serotonin production during acute inflammatory response

[Term]
id: GO:0002443
name: leukocyte mediated immunity
namespace: biological_process
alt_id: GO:0019723
alt_id: GO:0042087
def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
synonym: "cell-mediated immune response" RELATED []
synonym: "cellular immune response" RELATED []
synonym: "immune cell effector process" EXACT []
synonym: "immune cell mediated immunity" EXACT []
synonym: "leucocyte immune effector process" EXACT []
synonym: "leucocyte mediated immunity" EXACT []
synonym: "leukocyte immune effector process" EXACT []
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0002444
name: myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
synonym: "myeloid leucocyte immune effector process" EXACT []
synonym: "myeloid leucocyte mediated immunity" EXACT []
synonym: "myeloid leukocyte immune effector process" EXACT []
is_a: GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002445
name: type II hypersensitivity
namespace: biological_process
def: "An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
xref: Wikipedia:Type_II_hypersensitivity
is_a: GO:0002444 ! myeloid leukocyte mediated immunity
is_a: GO:0002524 ! hypersensitivity
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002446
name: neutrophil mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a neutrophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002447
name: eosinophil mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by an eosinophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002448
name: mast cell mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a mast cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002449
name: lymphocyte mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
synonym: "cell-mediated immunity" BROAD []
synonym: "cellular immune response" BROAD []
is_a: GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002450
name: B cell antigen processing and presentation
namespace: biological_process
def: "The process by which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
synonym: "B lymphocyte antigen processing and presentation" EXACT []
synonym: "B-cell antigen processing and presentation" EXACT []
synonym: "B-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0019882 ! antigen processing and presentation
relationship: part_of GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002451
name: peripheral B cell tolerance induction
namespace: biological_process
def: "Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "peripheral B lymphocyte tolerance induction" EXACT []
synonym: "peripheral B-cell tolerance induction" EXACT []
synonym: "peripheral B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002465 ! peripheral tolerance induction
is_a: GO:0002514 ! B cell tolerance induction
is_a: GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002452
name: B cell receptor editing
namespace: biological_process
def: "The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "B lymphocyte receptor editing" EXACT []
synonym: "B-cell receptor editing" EXACT []
synonym: "B-lymphocyte receptor editing" EXACT []
is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments

[Term]
id: GO:0002453
name: peripheral B cell anergy
namespace: biological_process
def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "peripheral B lymphocyte anergy" EXACT []
synonym: "peripheral B-cell anergy" EXACT []
synonym: "peripheral B-lymphocyte anergy" EXACT []
is_a: GO:0002515 ! B cell anergy
relationship: part_of GO:0002451 ! peripheral B cell tolerance induction

[Term]
id: GO:0002454
name: peripheral B cell deletion
namespace: biological_process
def: "The deletion of B cells by apoptosis occurring as part of peripheral tolerance induction and B cell selection." [GOC:add, GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "peripheral B lymphocyte deletion" EXACT []
synonym: "peripheral B-cell deletion" EXACT []
synonym: "peripheral B-lymphocyte deletion" EXACT []
is_a: GO:0002516 ! B cell deletion
relationship: part_of GO:0002451 ! peripheral B cell tolerance induction

[Term]
id: GO:0002455
name: humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def: "An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
synonym: "circulating antibody mediated immune response" EXACT []
synonym: "circulating immunoglobulin mediated immune response" EXACT []
synonym: "humoral defence mechanism" RELATED []
synonym: "humoral immune response mediated by circulating antibody" EXACT []
is_a: GO:0006959 ! humoral immune response
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002456
name: T cell mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
synonym: "cell-mediated immunity" BROAD []
synonym: "cellular immune response" BROAD []
synonym: "T lymphocyte mediated immunity" EXACT []
synonym: "T-cell mediated immunity" EXACT []
synonym: "T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002457
name: T cell antigen processing and presentation
namespace: biological_process
def: "The process by which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183]
synonym: "T lymphocyte antigen processing and presentation" EXACT []
synonym: "T-cell antigen processing and presentation" EXACT []
synonym: "T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0019882 ! antigen processing and presentation
relationship: part_of GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002458
name: peripheral T cell tolerance induction
namespace: biological_process
def: "Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "peripheral T lymphocyte tolerance induction" EXACT []
synonym: "peripheral T-cell tolerance induction" EXACT []
synonym: "peripheral T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002456 ! T cell mediated immunity
is_a: GO:0002465 ! peripheral tolerance induction
is_a: GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002459
name: adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains
namespace: biological_process
def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae)." [GOC:add, GOC:mtg_sensu, PMID:16373579]
synonym: "adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains" EXACT []
synonym: "adaptive immune response based on somatic recombination of VLR built from LRR domains" EXACT []
synonym: "adaptive immune response in jawless fish" EXACT []
is_a: GO:0002250 ! adaptive immune response

[Term]
id: GO:0002460
name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002250 ! adaptive immune response

[Term]
id: GO:0002461
name: tolerance induction dependent upon immune response
namespace: biological_process
def: "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
synonym: "immune response-dependent tolerance induction" EXACT []
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002462
name: tolerance induction to nonself antigen
namespace: biological_process
def: "Tolerance induction in response to nonself antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002463
name: central tolerance induction to nonself antigen
namespace: biological_process
def: "Tolerance induction to nonself antigens in the central lymphoid organs." [GOC:jal, PMID:12547504]
is_a: GO:0002462 ! tolerance induction to nonself antigen
is_a: GO:0002508 ! central tolerance induction

[Term]
id: GO:0002464
name: peripheral tolerance induction to nonself antigen
namespace: biological_process
def: "Tolerance induction to nonself antigens in the periphery." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002462 ! tolerance induction to nonself antigen
is_a: GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002465
name: peripheral tolerance induction
namespace: biological_process
def: "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002466
name: peripheral tolerance induction to self antigen
namespace: biological_process
def: "Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002465 ! peripheral tolerance induction
is_a: GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002467
name: germinal center formation
namespace: biological_process
def: "The process by which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:081533642X]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002468
name: dendritic cell antigen processing and presentation
namespace: biological_process
def: "The process by which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002469
name: myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "The process by which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
is_a: GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002470
name: plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def: "The process by which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
is_a: GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002471
name: monocyte antigen processing and presentation
namespace: biological_process
def: "The process by which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002472
name: macrophage antigen processing and presentation
namespace: biological_process
def: "The process by which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002473
name: non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def: "The process by which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002474
name: antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591]
synonym: "peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002475
name: antigen processing and presentation via MHC class Ib
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, PMID:15928678, PMID:15928680]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002476
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "endogenous peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib
is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen

[Term]
id: GO:0002477
name: antigen processing and presentation of exogenous peptide antigen via MHC class Ib
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "exogenous peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib
is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen

[Term]
id: GO:0002478
name: antigen processing and presentation of exogenous peptide antigen
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "exogenous peptide antigen processing and presentation" EXACT []
is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002479
name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335]
synonym: "cross presentation" BROAD []
synonym: "cross-presentation" BROAD []
synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent" EXACT []
synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT []
synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I

[Term]
id: GO:0002480
name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335]
synonym: "cross presentation" BROAD []
synonym: "cross-presentation" BROAD []
synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-independent" EXACT []
synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT []
synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I

[Term]
id: GO:0002481
name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent" EXACT []
synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT []
synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib

[Term]
id: GO:0002482
name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent" EXACT []
synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT []
synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib

[Term]
id: GO:0002483
name: antigen processing and presentation of endogenous peptide antigen
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "endogenous peptide antigen processing and presentation" EXACT []
is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002484
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14647477, PMID:15771591]
synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT []
is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I

[Term]
id: GO:0002485
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14647477, PMID:15771591]
synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent" EXACT []
synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT []
synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT []
is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway

[Term]
id: GO:0002486
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules." [GOC:add, PMID:14647477, PMID:15771591]
synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent" EXACT []
synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT []
synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT []
is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway

[Term]
id: GO:0002487
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules." [GOC:add, PMID:10631943]
synonym: "endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway" EXACT []
is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I

[Term]
id: GO:0002488
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT []
is_a: GO:0002476 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib

[Term]
id: GO:0002489
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent" EXACT []
synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT []
synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT []
is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway

[Term]
id: GO:0002490
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent" EXACT []
synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT []
synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT []
is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway

[Term]
id: GO:0002491
name: antigen processing and presentation of endogenous peptide antigen via MHC class II
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, PMID:15531770, PMID:16181338]
synonym: "endogenous peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen
is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002492
name: peptide antigen assembly with MHC class Ib protein complex
namespace: biological_process
def: "The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]
is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex
relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly
relationship: part_of GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib

[Term]
id: GO:0002493
name: lipid antigen assembly with MHC class Ib protein complex
namespace: biological_process
def: "The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family." [GOC:add, PMID:15928678, PMID:15928680]
is_a: GO:0065005 ! protein-lipid complex assembly
relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly
relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002494
name: lipid antigen transport
namespace: biological_process
def: "The directed movement of a lipid antigen into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:add, PMID:15928678, PMID:15928680]
is_a: GO:0006869 ! lipid transport
relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002495
name: antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15531770, PMID:15771591]
synonym: "peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002496
name: proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591]
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process
relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002497
name: proteasomal proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591]
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation
is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process

[Term]
id: GO:0002498
name: proteolysis within endoplasmic reticulum associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591]
synonym: "endoplasmic reticulum proteolysis associated with antigen processing and presentation" EXACT []
synonym: "ER proteolysis associated with antigen processing and presentation" EXACT []
synonym: "proteolysis within ER associated with antigen processing and presentation" EXACT []
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002499
name: proteolysis within endosome associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
synonym: "endosomal proteolysis associated with antigen processing and presentation" EXACT []
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002500
name: proteolysis within lysosome associated with antigen processing and presentation
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
synonym: "lysosomal proteolysis associated with antigen processing and presentation" EXACT []
is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation
is_a: GO:0007039 ! vacuolar protein catabolic process

[Term]
id: GO:0002501
name: peptide antigen assembly with MHC protein complex
namespace: biological_process
def: "The binding of a peptide to the antigen binding groove of an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0002396 ! MHC protein complex assembly
relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002502
name: peptide antigen assembly with MHC class I protein complex
namespace: biological_process
def: "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex
relationship: part_of GO:0002397 ! MHC class I protein complex assembly
relationship: part_of GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0002503
name: peptide antigen assembly with MHC class II protein complex
namespace: biological_process
def: "The binding of a peptide to the antigen binding groove of an MHC class II protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex
relationship: part_of GO:0002399 ! MHC class II protein complex assembly
relationship: part_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002504
name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15531770, PMID:15771591, PMID:16153240]
synonym: "peptide or polysaccharide antigen processing and presentation of via MHC class II" EXACT []
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002505
name: antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, PMID:16153240]
synonym: "polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002506
name: polysaccharide assembly with MHC class II protein complex
namespace: biological_process
def: "The binding of a polysaccharide to the antigen binding groove of an MHC class II protein complex." [GOC:add, PMID:16153240]
is_a: GO:0065006 ! protein-carbohydrate complex assembly
relationship: part_of GO:0002399 ! MHC class II protein complex assembly
relationship: part_of GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II

[Term]
id: GO:0002507
name: tolerance induction
namespace: biological_process
def: "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0002508
name: central tolerance induction
namespace: biological_process
def: "Tolerance induction in the central lymphoid organs: the thymus and bone marrow." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002507 ! tolerance induction
relationship: part_of GO:0002520 ! immune system development

[Term]
id: GO:0002509
name: central tolerance induction to self antigen
namespace: biological_process
def: "Tolerance induction in the central lymphoid organs directed at self antigens." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16460922]
is_a: GO:0002508 ! central tolerance induction
is_a: GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002510
name: central B cell tolerance induction
namespace: biological_process
def: "Tolerance induction of B cells in the bone marrow." [GOC:jal, PMID:16460922]
synonym: "central B lymphocyte tolerance induction" EXACT []
synonym: "central B-cell tolerance induction" EXACT []
synonym: "central B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002508 ! central tolerance induction
is_a: GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002511
name: central B cell receptor editing
namespace: biological_process
def: "Receptor editing occurring in B cells in the bone marrow." [GOC:jal, PMID:16460922]
synonym: "central B lymphocyte receptor editing" EXACT []
synonym: "central B-cell receptor editing" EXACT []
synonym: "central B-lymphocyte receptor editing" EXACT []
is_a: GO:0002452 ! B cell receptor editing

[Term]
id: GO:0002512
name: central T cell tolerance induction
namespace: biological_process
def: "Tolerance induction of T cells in the thymus." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "central T lymphocyte tolerance induction" EXACT []
synonym: "central T-cell tolerance induction" EXACT []
synonym: "central T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002508 ! central tolerance induction
is_a: GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002513
name: tolerance induction to self antigen
namespace: biological_process
def: "Tolerance induction directed at self antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002514
name: B cell tolerance induction
namespace: biological_process
def: "A process involving any mechanism for tolerance induction in B cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16460922]
synonym: "B lymphocyte tolerance induction" EXACT []
synonym: "B-cell tolerance induction" EXACT []
synonym: "B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002515
name: B cell anergy
namespace: biological_process
def: "Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "B lymphocyte anergy" EXACT []
synonym: "B-cell anergy" EXACT []
synonym: "B-lymphocyte anergy" EXACT []
is_a: GO:0002249 ! lymphocyte anergy
is_a: GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002516
name: B cell deletion
namespace: biological_process
def: "The apoptotic death of B cells which is part of B cell tolerance induction." [GOC:add, GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "B lymphocyte deletion" EXACT []
synonym: "B-cell deletion" EXACT []
synonym: "B-lymphocyte deletion" EXACT []
is_a: GO:0001783 ! B cell apoptosis
relationship: part_of GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002517
name: T cell tolerance induction
namespace: biological_process
def: "A process involving any mechanism for tolerance induction in T cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16551263]
synonym: "T lymphocyte tolerance induction" EXACT []
synonym: "T-cell tolerance induction" EXACT []
synonym: "T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002518
name: lymphocyte chemotaxis across high endothelial venule
namespace: biological_process
def: "The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15122201]
is_a: GO:0048247 ! lymphocyte chemotaxis

[Term]
id: GO:0002519
name: natural killer cell tolerance induction
namespace: biological_process
def: "Tolerance induction of natural killer cells." [GOC:jal, PMID:16546094]
synonym: "NK cell tolerance induction" EXACT []
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0002520
name: immune system development
namespace: biological_process
def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]
is_a: GO:0002376 ! immune system process
is_a: GO:0048731 ! system development

[Term]
id: GO:0002521
name: leukocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell or any cell of the myeloid leukocyte or lymphocyte lineages." [GOC:add, PMID:16551264]
synonym: "immune cell differentiation" EXACT []
synonym: "leucocyte differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0002522
name: leukocyte migration during immune response
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body during an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration during immune response" EXACT []
synonym: "immune cell trafficking during immune response" EXACT []
synonym: "leucocyte migration during immune response" EXACT []
synonym: "leucocyte trafficking during immune response" EXACT []
synonym: "leukocyte trafficking during immune response" EXACT []
is_a: GO:0050900 ! leukocyte migration

[Term]
id: GO:0002523
name: leukocyte migration during inflammatory response
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body during an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration during inflammatory response" EXACT []
synonym: "immune cell trafficking during inflammatory response" EXACT []
synonym: "leucocyte migration during inflammatory response" EXACT []
synonym: "leucocyte trafficking during inflammatory response" EXACT []
synonym: "leukocyte trafficking during inflammatory response" EXACT []
is_a: GO:0050900 ! leukocyte migration
relationship: part_of GO:0006954 ! inflammatory response

[Term]
id: GO:0002524
name: hypersensitivity
namespace: biological_process
def: "An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "hypersensitivity response" RELATED [ISBN:0781735149 "Fundamental Immunology"]
xref: Wikipedia:Hypersensitivity
is_a: GO:0002438 ! acute inflammatory response to antigenic stimulus

[Term]
id: GO:0002525
name: acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma." [GOC:jal, PMID:16459497, PMID:9073326]
is_a: GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002526
name: acute inflammatory response
namespace: biological_process
def: "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0006954 ! inflammatory response

[Term]
id: GO:0002527
name: vasodilation during acute inflammatory response
namespace: biological_process
def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure during an acute inflammatory response." [GOC:jal]
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002528
name: regulation of vascular permeability during acute inflammatory response
namespace: biological_process
def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid during an acute inflammatory response." [GOC:jal]
is_a: GO:0043114 ! regulation of vascular permeability
relationship: part_of GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002529
name: regulation of plasma kallikrein-kinin cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add]
is_a: GO:0002256 ! regulation of kinin cascade
relationship: regulates GO:0002353 ! plasma kallikrein-kinin cascade

[Term]
id: GO:0002530
name: regulation of systemic arterial blood pressure during acute phase response
namespace: biological_process
def: "Any process that modulates the force with which blood travels through the circulatory system during the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, ISBN:081533642X]
synonym: "blood pressure regulation during acute phase response" EXACT []
is_a: GO:0003073 ! regulation of systemic arterial blood pressure
relationship: part_of GO:0006953 ! acute-phase response

[Term]
id: GO:0002531
name: regulation of heart contraction during acute phase response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heart contraction during the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, PMID:15642986, PMID:15834430]
synonym: "regulation of cardiac contraction during acute phase response" EXACT []
is_a: GO:0008016 ! regulation of heart contraction
relationship: part_of GO:0006953 ! acute-phase response

[Term]
id: GO:0002532
name: production of molecular mediator of acute inflammatory response
namespace: biological_process
def: "The synthesis or release of any molecular mediator of the acute inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "production of cellular mediator of acute inflammation" RELATED []
is_a: GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002533
name: secretion of lysosomal enzymes during acute inflammatory response
namespace: biological_process
def: "The regulated release of lysosomal enzymes by a cell or group of cells during an acute inflammatory response." [GOC:jal, PMID:11836514]
is_a: GO:0033299 ! secretion of lysosomal enzymes
relationship: part_of GO:0002393 ! production of lysosomal enzymes during acute inflammatory response

[Term]
id: GO:0002534
name: cytokine production during acute inflammatory response
namespace: biological_process
def: "The synthesis or release of a cytokine following a inflammatory stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001816 ! cytokine production
is_a: GO:0002532 ! production of molecular mediator of acute inflammatory response

[Term]
id: GO:0002535
name: platelet activating factor secretion during acute inflammatory response
namespace: biological_process
def: "The regulated release of platelet activating factor by a cell or group of cells during an acute inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002392 ! platelet activating factor secretion
relationship: part_of GO:0002391 ! platelet activating factor production during acute inflammatory response

[Term]
id: GO:0002536
name: respiratory burst during acute inflammatory response
namespace: biological_process
def: "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus during an acute inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "oxidative burst during acute inflammatory response " EXACT []
synonym: "production of reactive oxygen species during acute inflammatory response" EXACT []
is_a: GO:0002532 ! production of molecular mediator of acute inflammatory response
is_a: GO:0002679 ! respiratory burst during defense response

[Term]
id: GO:0002537
name: production of nitric oxide during acute inflammatory response
namespace: biological_process
def: "The synthesis or release of nitric oxide following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002532 ! production of molecular mediator of acute inflammatory response

[Term]
id: GO:0002538
name: production of arachidonic acid metabolites during acute inflammatory response
namespace: biological_process
def: "The synthesis or release of products of arachidonic acid metabolism following a stimulus during an acute inflammatory response, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002532 ! production of molecular mediator of acute inflammatory response

[Term]
id: GO:0002539
name: prostaglandin production during acute inflammatory response
namespace: biological_process
def: "The synthesis or release of any prostaglandin following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002538 ! production of arachidonic acid metabolites during acute inflammatory response

[Term]
id: GO:0002540
name: leukotriene production during acute inflammatory response
namespace: biological_process
def: "The synthesis or release of any leukotriene following a stimulus during an acute inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002538 ! production of arachidonic acid metabolites during acute inflammatory response

[Term]
id: GO:0002541
name: activation of plasma proteins involved in acute inflammatory response
namespace: biological_process
def: "Any process activating plasma proteins by proteolysis as part of an acute inflammatory response." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0051605 ! protein maturation by peptide bond cleavage
relationship: part_of GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002542
name: Factor XII activation
namespace: biological_process
def: "Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade." [GOC:jal, ISBN:0721601871]
synonym: "Hageman factor activation" EXACT []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0010954 ! positive regulation of protein maturation by peptide bond cleavage
relationship: part_of GO:0002353 ! plasma kallikrein-kinin cascade
relationship: positively_regulates GO:0002541 ! activation of plasma proteins involved in acute inflammatory response

[Term]
id: GO:0002543
name: activation of blood coagulation via clotting cascade
namespace: biological_process
def: "Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of clotting cascade" EXACT []
is_a: GO:0030194 ! positive regulation of blood coagulation
relationship: part_of GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002544
name: chronic inflammatory response
namespace: biological_process
def: "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was added by GO_REF:0000022.
is_a: GO:0006954 ! inflammatory response

[Term]
id: GO:0002545
name: chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma." [GOC:jal]
is_a: GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002546
name: negative regulation of tissue kallikrein-kinin cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add]
synonym: "down regulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "down-regulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "downregulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "inhibition of tissue kallikrein-kinin cascade" NARROW []
synonym: "negative regulation of glandular kallikrein-kinin cascade" EXACT []
is_a: GO:0002257 ! negative regulation of kinin cascade
is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade
relationship: negatively_regulates GO:0002255 ! tissue kallikrein-kinin cascade

[Term]
id: GO:0002547
name: positive regulation of tissue kallikrein-kinin cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add]
synonym: "activation of tissue kallikrein-kinin cascade" NARROW []
synonym: "positive regulation of glandular kallikrein-kinin cascade" EXACT []
synonym: "stimulation of tissue kallikrein-kinin cascade" NARROW []
synonym: "up regulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "up-regulation of tissue kallikrein-kinin cascade" EXACT []
synonym: "upregulation of tissue kallikrein-kinin cascade" EXACT []
is_a: GO:0002258 ! positive regulation of kinin cascade
is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade
relationship: positively_regulates GO:0002255 ! tissue kallikrein-kinin cascade

[Term]
id: GO:0002548
name: monocyte chemotaxis
namespace: biological_process
def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832]
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002549
name: negative regulation of plasma kallikrein-kinin cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add]
synonym: "down regulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "down-regulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "downregulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "inhibition of plasma kallikrein-kinin cascade" NARROW []
is_a: GO:0002257 ! negative regulation of kinin cascade
is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade
relationship: negatively_regulates GO:0002353 ! plasma kallikrein-kinin cascade

[Term]
id: GO:0002550
name: positive regulation of plasma kallikrein-kinin cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add]
synonym: "activation of plasma kallikrein-kinin cascade" NARROW []
synonym: "stimulation of plasma kallikrein-kinin cascade" NARROW []
synonym: "up regulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "up-regulation of plasma kallikrein-kinin cascade" EXACT []
synonym: "upregulation of plasma kallikrein-kinin cascade" EXACT []
is_a: GO:0002258 ! positive regulation of kinin cascade
is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade
relationship: positively_regulates GO:0002353 ! plasma kallikrein-kinin cascade

[Term]
id: GO:0002551
name: mast cell chemotaxis
namespace: biological_process
def: "The movement of a mast cell in response to an external stimulus." [GOC:add, PMID:11292027, PMID:12789214, PMID:16448392]
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002552
name: serotonin secretion by mast cell
namespace: biological_process
def: "The regulated release of serotonin by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002442 ! serotonin secretion during acute inflammatory response
relationship: part_of GO:0043303 ! mast cell degranulation

[Term]
id: GO:0002553
name: histamine secretion by mast cell
namespace: biological_process
def: "The regulated release of histamine by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002441 ! histamine secretion during acute inflammatory response
relationship: part_of GO:0043303 ! mast cell degranulation

[Term]
id: GO:0002554
name: serotonin secretion by platelet
namespace: biological_process
def: "The regulated release of serotonin by a platelet or group of platelets." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002442 ! serotonin secretion during acute inflammatory response
relationship: part_of GO:0002576 ! platelet degranulation

[Term]
id: GO:0002555
name: histamine secretion by platelet
namespace: biological_process
def: "The regulated release of histamine by a platelet or group of platelets." [GOC:add, PMID:9117517]
is_a: GO:0002441 ! histamine secretion during acute inflammatory response
relationship: part_of GO:0002576 ! platelet degranulation

[Term]
id: GO:0002556
name: serotonin secretion by basophil
namespace: biological_process
def: "The regulated release of serotonin by a basophil or group of basophils." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002442 ! serotonin secretion during acute inflammatory response
relationship: part_of GO:0002561 ! basophil degranulation

[Term]
id: GO:0002557
name: histamine secretion by basophil
namespace: biological_process
def: "The regulated release of histamine by a basophil or group of basophils." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002441 ! histamine secretion during acute inflammatory response
relationship: part_of GO:0002561 ! basophil degranulation

[Term]
id: GO:0002558
name: type I hypersensitivity mediated by mast cells
namespace: biological_process
def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002448 ! mast cell mediated immunity
is_a: GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0002559
name: type I hypersensitivity mediated by basophils
namespace: biological_process
def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002560 ! basophil mediated immunity
is_a: GO:0016068 ! type I hypersensitivity

[Term]
id: GO:0002560
name: basophil mediated immunity
namespace: biological_process
def: "Any process involved in the carrying out of an immune response by a basophil." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002561
name: basophil degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002276 ! basophil activation during immune response
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0002560 ! basophil mediated immunity

[Term]
id: GO:0002562
name: somatic diversification of immune receptors via germline recombination within a single locus
namespace: biological_process
def: "The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16102575, PMID:16166509]
is_a: GO:0002200 ! somatic diversification of immune receptors
is_a: GO:0016444 ! somatic cell DNA recombination

[Term]
id: GO:0002563
name: somatic diversification of immune receptors via alternate splicing
namespace: biological_process
def: "The process by which immune receptor genes are diversified through alternate splicing." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16166509]
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002564
name: alternate splicing of immunoglobulin genes
namespace: biological_process
def: "The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons." [ISBN:0781735149 "Fundamental Immunology", PMID:9185563]
synonym: "alternate splicing of antibody genes" EXACT []
is_a: GO:0002563 ! somatic diversification of immune receptors via alternate splicing
is_a: GO:0016445 ! somatic diversification of immunoglobulins

[Term]
id: GO:0002565
name: somatic diversification of immune receptors via gene conversion
namespace: biological_process
def: "The process by which immune receptor genes are diversified through gene conversion." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002200 ! somatic diversification of immune receptors
is_a: GO:0016444 ! somatic cell DNA recombination

[Term]
id: GO:0002566
name: somatic diversification of immune receptors via somatic mutation
namespace: biological_process
def: "The process by which immune receptor genes are diversified through somatic mutation." [ISBN:0781735149 "Fundamental Immunology", PMID:16102575]
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002567
name: somatic diversification of FREP-based immune receptors
namespace: biological_process
def: "The process by means of which sequence diversity of the FREP-based immune receptors of snails is generated." [GOC:add, PMID:16102575]
comment: Note that this type of immune receptor has been found in snails (Pulmonata, ncbi_axonomy_id:6519), but may also be seen in other species.
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002568
name: somatic diversification of T cell receptor genes
namespace: biological_process
def: "The somatic process by means of which sequence diversity of T cell receptor genes is generated." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "somatic diversification of TCR genes" EXACT []
is_a: GO:0002200 ! somatic diversification of immune receptors
relationship: part_of GO:0030217 ! T cell differentiation

[Term]
id: GO:0002569
name: somatic diversification of immune receptors by N region addition
namespace: biological_process
def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002200 ! somatic diversification of immune receptors

[Term]
id: GO:0002570
name: somatic diversification of immunoglobulin genes by N region addition
namespace: biological_process
def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "somatic diversification of antibody genes by N region addition" EXACT []
is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition
is_a: GO:0016445 ! somatic diversification of immunoglobulins
relationship: part_of GO:0016447 ! somatic recombination of immunoglobulin gene segments

[Term]
id: GO:0002571
name: somatic diversification of T cell receptor genes by N region addition
namespace: biological_process
def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "somatic diversification of TCR genes by N region addition" EXACT []
is_a: GO:0002568 ! somatic diversification of T cell receptor genes
is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition
relationship: part_of GO:0002681 ! somatic recombination of T cell receptor gene segments

[Term]
id: GO:0002572
name: pro-T cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "pro-T lymphocyte differentiation " EXACT []
is_a: GO:0002320 ! lymphoid progenitor cell differentiation
relationship: part_of GO:0030217 ! T cell differentiation

[Term]
id: GO:0002573
name: myeloid leukocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251]
synonym: "myeloid leucocyte differentiation" EXACT []
is_a: GO:0002521 ! leukocyte differentiation
is_a: GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0002574
name: thrombocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." [GOC:add]
comment: Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220.
is_a: GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0002575
name: basophil chemotaxis
namespace: biological_process
def: "The movement of a basophil in response to an external stimulus." [GOC:add, PMID:11292027]
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002576
name: platelet degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet." [GOC:add]
synonym: "platelet exocytosis" EXACT []
xref: Reactome:114608 "Platelet degranulation"
xref: Reactome:449086 "Platelet degranulation"
xref: Reactome:470198 "Platelet degranulation"
xref: Reactome:487883 "Platelet degranulation"
xref: Reactome:507856 "Platelet degranulation"
xref: Reactome:517760 "Platelet degranulation"
xref: Reactome:526595 "Platelet degranulation"
xref: Reactome:531391 "Platelet degranulation"
xref: Reactome:536766 "Platelet degranulation"
xref: Reactome:542520 "Platelet degranulation"
xref: Reactome:547843 "Platelet degranulation"
xref: Reactome:552415 "Platelet degranulation"
xref: Reactome:558024 "Platelet degranulation"
xref: Reactome:568674 "Platelet degranulation"
xref: Reactome:581877 "Platelet degranulation"
xref: Reactome:585931 "Platelet degranulation"
xref: Reactome:592782 "Platelet degranulation"
xref: Reactome:595506 "Platelet degranulation"
xref: Reactome:597405 "Platelet degranulation"
xref: Reactome:599749 "Platelet degranulation"
xref: Reactome:600648 "Platelet degranulation"
is_a: GO:0006887 ! exocytosis

[Term]
id: GO:0002577
name: regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
relationship: regulates GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002578
name: negative regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
synonym: "down regulation of antigen processing and presentation" EXACT []
synonym: "down-regulation of antigen processing and presentation" EXACT []
synonym: "downregulation of antigen processing and presentation" EXACT []
synonym: "inhibition of antigen processing and presentation" NARROW []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002683 ! negative regulation of immune system process
relationship: negatively_regulates GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002579
name: positive regulation of antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add]
synonym: "activation of antigen processing and presentation" NARROW []
synonym: "stimulation of antigen processing and presentation" NARROW []
synonym: "up regulation of antigen processing and presentation" EXACT []
synonym: "up-regulation of antigen processing and presentation" EXACT []
synonym: "upregulation of antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002684 ! positive regulation of immune system process
relationship: positively_regulates GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002580
name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
relationship: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002581
name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002582
name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

[Term]
id: GO:0002583
name: regulation of antigen processing and presentation of peptide antigen
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
relationship: regulates GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002584
name: negative regulation of antigen processing and presentation of peptide antigen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
relationship: negatively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002585
name: positive regulation of antigen processing and presentation of peptide antigen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
relationship: positively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0002586
name: regulation of antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
relationship: regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002587
name: negative regulation of antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class II" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II
relationship: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002588
name: positive regulation of antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen via MHC class II" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation via MHC class II" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class II" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT []
is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II
relationship: positively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0002589
name: regulation of antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
relationship: regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0002590
name: negative regulation of antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class I" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I
relationship: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0002591
name: positive regulation of antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen via MHC class I" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation via MHC class I" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class I" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT []
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I
relationship: positively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I

[Term]
id: GO:0002592
name: regulation of antigen processing and presentation via MHC class Ib
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
relationship: regulates GO:0002475 ! antigen processing and presentation via MHC class Ib

[Term]
id: GO:0002593
name: negative regulation of antigen processing and presentation via MHC class Ib
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add]
synonym: "down regulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "down-regulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "downregulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "inhibition of antigen processing and presentation via MHC class Ib" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib
relationship: negatively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib

[Term]
id: GO:0002594
name: positive regulation of antigen processing and presentation via MHC class Ib
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add]
synonym: "activation of antigen processing and presentation via MHC class Ib" NARROW []
synonym: "stimulation of antigen processing and presentation via MHC class Ib" NARROW []
synonym: "up regulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "up-regulation of antigen processing and presentation via MHC class Ib" EXACT []
synonym: "upregulation of antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib
relationship: positively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib

[Term]
id: GO:0002595
name: regulation of antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add]
synonym: "regulation of peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib
relationship: regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib

[Term]
id: GO:0002596
name: negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add]
synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW []
synonym: "negative regulation of peptide antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib
is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib
relationship: negatively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib

[Term]
id: GO:0002597
name: positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add]
synonym: "activation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW []
synonym: "positive regulation of peptide antigen processing and presentation via MHC class Ib" EXACT []
synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW []
synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT []
is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen
is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib
is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib
relationship: positively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib

[Term]
id: GO:0002598
name: regulation of antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add]
synonym: "regulation of lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib
relationship: regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002599
name: negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add]
synonym: "down regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "downregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "inhibition of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW []
synonym: "negative regulation of lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib
is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib
relationship: negatively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002600
name: positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add]
synonym: "activation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW []
synonym: "positive regulation of lipid antigen processing and presentation via MHC class Ib" EXACT []
synonym: "stimulation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW []
synonym: "up regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
synonym: "upregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT []
is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib
is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib
relationship: positively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0002601
name: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add]
synonym: "regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
relationship: regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II

[Term]
id: GO:0002602
name: negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add]
synonym: "down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "inhibition of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW []
synonym: "negative regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
relationship: negatively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II

[Term]
id: GO:0002603
name: positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add]
synonym: "activation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW []
synonym: "positive regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT []
synonym: "stimulation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW []
synonym: "up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
synonym: "upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT []
is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
relationship: positively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II

[Term]
id: GO:0002604
name: regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
relationship: regulates GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002605
name: negative regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
relationship: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002606
name: positive regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
relationship: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation

[Term]
id: GO:0002607
name: regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
relationship: regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation

[Term]
id: GO:0002608
name: negative regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of myeloid dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation
is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation
relationship: negatively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation

[Term]
id: GO:0002609
name: positive regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of myeloid dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of myeloid dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of myeloid dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of myeloid dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation
is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation
relationship: positively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation

[Term]
id: GO:0002610
name: regulation of plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add]
is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation
relationship: regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation

[Term]
id: GO:0002611
name: negative regulation of plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "down-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "downregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "inhibition of plasmacytoid dendritic cell antigen processing and presentation" NARROW []
is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation
is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation
relationship: negatively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation

[Term]
id: GO:0002612
name: positive regulation of plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add]
synonym: "activation of plasmacytoid dendritic cell antigen processing and presentation" NARROW []
synonym: "stimulation of plasmacytoid dendritic cell antigen processing and presentation" NARROW []
synonym: "up regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "up-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
synonym: "upregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT []
is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation
is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation
relationship: positively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation

[Term]
id: GO:0002613
name: regulation of monocyte antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
relationship: regulates GO:0002471 ! monocyte antigen processing and presentation

[Term]
id: GO:0002614
name: negative regulation of monocyte antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
synonym: "down regulation of monocyte antigen processing and presentation" EXACT []
synonym: "down-regulation of monocyte antigen processing and presentation" EXACT []
synonym: "downregulation of monocyte antigen processing and presentation" EXACT []
synonym: "inhibition of monocyte antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation
relationship: negatively_regulates GO:0002471 ! monocyte antigen processing and presentation

[Term]
id: GO:0002615
name: positive regulation of monocyte antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]
synonym: "activation of monocyte antigen processing and presentation" NARROW []
synonym: "stimulation of monocyte antigen processing and presentation" NARROW []
synonym: "up regulation of monocyte antigen processing and presentation" EXACT []
synonym: "up-regulation of monocyte antigen processing and presentation" EXACT []
synonym: "upregulation of monocyte antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation
relationship: positively_regulates GO:0002471 ! monocyte antigen processing and presentation

[Term]
id: GO:0002616
name: regulation of macrophage antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
relationship: regulates GO:0002472 ! macrophage antigen processing and presentation

[Term]
id: GO:0002617
name: negative regulation of macrophage antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
synonym: "down regulation of macrophage antigen processing and presentation" EXACT []
synonym: "down-regulation of macrophage antigen processing and presentation" EXACT []
synonym: "downregulation of macrophage antigen processing and presentation" EXACT []
synonym: "inhibition of macrophage antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation
relationship: negatively_regulates GO:0002472 ! macrophage antigen processing and presentation

[Term]
id: GO:0002618
name: positive regulation of macrophage antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]
synonym: "activation of macrophage antigen processing and presentation" NARROW []
synonym: "stimulation of macrophage antigen processing and presentation" NARROW []
synonym: "up regulation of macrophage antigen processing and presentation" EXACT []
synonym: "up-regulation of macrophage antigen processing and presentation" EXACT []
synonym: "upregulation of macrophage antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation
relationship: positively_regulates GO:0002472 ! macrophage antigen processing and presentation

[Term]
id: GO:0002619
name: regulation of non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add]
is_a: GO:0002577 ! regulation of antigen processing and presentation
relationship: regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation

[Term]
id: GO:0002620
name: negative regulation of non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "down-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "downregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "inhibition of non-professional antigen presenting cell antigen processing and presentation" NARROW []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation
relationship: negatively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation

[Term]
id: GO:0002621
name: positive regulation of non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add]
synonym: "activation of non-professional antigen presenting cell antigen processing and presentation" NARROW []
synonym: "stimulation of non-professional antigen presenting cell antigen processing and presentation" NARROW []
synonym: "up regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "up-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
synonym: "upregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation
relationship: positively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation

[Term]
id: GO:0002622
name: regulation of B cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]
synonym: "regulation of B lymphocyte antigen processing and presentation" EXACT []
synonym: "regulation of B-cell antigen processing and presentation" EXACT []
synonym: "regulation of B-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002712 ! regulation of B cell mediated immunity
relationship: regulates GO:0002450 ! B cell antigen processing and presentation

[Term]
id: GO:0002623
name: negative regulation of B cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of B cell antigen processing and presentation" EXACT []
synonym: "down-regulation of B cell antigen processing and presentation" EXACT []
synonym: "downregulation of B cell antigen processing and presentation" EXACT []
synonym: "inhibition of B cell antigen processing and presentation" NARROW []
synonym: "negative regulation of B lymphocyte antigen processing and presentation" EXACT []
synonym: "negative regulation of B-cell antigen processing and presentation" EXACT []
synonym: "negative regulation of B-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002622 ! regulation of B cell antigen processing and presentation
relationship: negatively_regulates GO:0002450 ! B cell antigen processing and presentation

[Term]
id: GO:0002624
name: positive regulation of B cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]
synonym: "activation of B cell antigen processing and presentation" NARROW []
synonym: "positive regulation of B lymphocyte antigen processing and presentation" EXACT []
synonym: "positive regulation of B-cell antigen processing and presentation" EXACT []
synonym: "positive regulation of B-lymphocyte antigen processing and presentation" EXACT []
synonym: "stimulation of B cell antigen processing and presentation" NARROW []
synonym: "up regulation of B cell antigen processing and presentation" EXACT []
synonym: "up-regulation of B cell antigen processing and presentation" EXACT []
synonym: "upregulation of B cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002622 ! regulation of B cell antigen processing and presentation
relationship: positively_regulates GO:0002450 ! B cell antigen processing and presentation

[Term]
id: GO:0002625
name: regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "regulation of T-cell antigen processing and presentation" EXACT []
synonym: "regulation of T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002577 ! regulation of antigen processing and presentation
is_a: GO:0002709 ! regulation of T cell mediated immunity
relationship: regulates GO:0002457 ! T cell antigen processing and presentation

[Term]
id: GO:0002626
name: negative regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "down regulation of T cell antigen processing and presentation" EXACT []
synonym: "down-regulation of T cell antigen processing and presentation" EXACT []
synonym: "downregulation of T cell antigen processing and presentation" EXACT []
synonym: "inhibition of T cell antigen processing and presentation" NARROW []
synonym: "negative regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "negative regulation of T-cell antigen processing and presentation" EXACT []
synonym: "negative regulation of T-lymphocyte antigen processing and presentation" EXACT []
is_a: GO:0002578 ! negative regulation of antigen processing and presentation
is_a: GO:0002625 ! regulation of T cell antigen processing and presentation
relationship: negatively_regulates GO:0002457 ! T cell antigen processing and presentation

[Term]
id: GO:0002627
name: positive regulation of T cell antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]
synonym: "activation of T cell antigen processing and presentation" NARROW []
synonym: "positive regulation of T lymphocyte antigen processing and presentation" EXACT []
synonym: "positive regulation of T-cell antigen processing and presentation" EXACT []
synonym: "positive regulation of T-lymphocyte antigen processing and presentation" EXACT []
synonym: "stimulation of T cell antigen processing and presentation" NARROW []
synonym: "up regulation of T cell antigen processing and presentation" EXACT []
synonym: "up-regulation of T cell antigen processing and presentation" EXACT []
synonym: "upregulation of T cell antigen processing and presentation" EXACT []
is_a: GO:0002579 ! positive regulation of antigen processing and presentation
is_a: GO:0002625 ! regulation of T cell antigen processing and presentation
relationship: positively_regulates GO:0002457 ! T cell antigen processing and presentation

[Term]
id: GO:0002628
name: regulation of proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]
is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
relationship: regulates GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002629
name: negative regulation of proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]
synonym: "down regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "down-regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "downregulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "inhibition of proteolysis associated with antigen processing and presentation" NARROW []
is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:0045861 ! negative regulation of proteolysis
relationship: negatively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002630
name: positive regulation of proteolysis associated with antigen processing and presentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]
synonym: "activation of proteolysis associated with antigen processing and presentation" NARROW []
synonym: "stimulation of proteolysis associated with antigen processing and presentation" NARROW []
synonym: "up regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "up-regulation of proteolysis associated with antigen processing and presentation" EXACT []
synonym: "upregulation of proteolysis associated with antigen processing and presentation" EXACT []
is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:0045862 ! positive regulation of proteolysis
relationship: positively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation

[Term]
id: GO:0002631
name: regulation of granuloma formation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of granuloma formation." [GOC:add]
is_a: GO:0002676 ! regulation of chronic inflammatory response
is_a: GO:0002697 ! regulation of immune effector process
relationship: regulates GO:0002432 ! granuloma formation

[Term]
id: GO:0002632
name: negative regulation of granuloma formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation." [GOC:add]
synonym: "down regulation of granuloma formation" EXACT []
synonym: "down-regulation of granuloma formation" EXACT []
synonym: "downregulation of granuloma formation" EXACT []
synonym: "inhibition of granuloma formation" NARROW []
is_a: GO:0002631 ! regulation of granuloma formation
is_a: GO:0002698 ! negative regulation of immune effector process
relationship: negatively_regulates GO:0002432 ! granuloma formation

[Term]
id: GO:0002633
name: positive regulation of granuloma formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of granuloma formation." [GOC:add]
synonym: "activation of granuloma formation" NARROW []
synonym: "stimulation of granuloma formation" NARROW []
synonym: "up regulation of granuloma formation" EXACT []
synonym: "up-regulation of granuloma formation" EXACT []
synonym: "upregulation of granuloma formation" EXACT []
is_a: GO:0002631 ! regulation of granuloma formation
is_a: GO:0002699 ! positive regulation of immune effector process
relationship: positively_regulates GO:0002432 ! granuloma formation

[Term]
id: GO:0002634
name: regulation of germinal center formation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of germinal center formation." [GOC:add]
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: regulates GO:0002467 ! germinal center formation

[Term]
id: GO:0002635
name: negative regulation of germinal center formation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation." [GOC:add]
synonym: "down regulation of germinal center formation" EXACT []
synonym: "down-regulation of germinal center formation" EXACT []
synonym: "downregulation of germinal center formation" EXACT []
synonym: "inhibition of germinal center formation" NARROW []
is_a: GO:0002634 ! regulation of germinal center formation
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: negatively_regulates GO:0002467 ! germinal center formation

[Term]
id: GO:0002636
name: positive regulation of germinal center formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of germinal center formation." [GOC:add]
synonym: "activation of germinal center formation" NARROW []
synonym: "stimulation of germinal center formation" NARROW []
synonym: "up regulation of germinal center formation" EXACT []
synonym: "up-regulation of germinal center formation" EXACT []
synonym: "upregulation of germinal center formation" EXACT []
is_a: GO:0002634 ! regulation of germinal center formation
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: positively_regulates GO:0002467 ! germinal center formation

[Term]
id: GO:0002637
name: regulation of immunoglobulin production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of immunoglobulin production." [GOC:add]
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
relationship: regulates GO:0002377 ! immunoglobulin production

[Term]
id: GO:0002638
name: negative regulation of immunoglobulin production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production." [GOC:add]
synonym: "down regulation of immunoglobulin production" EXACT []
synonym: "down-regulation of immunoglobulin production" EXACT []
synonym: "downregulation of immunoglobulin production" EXACT []
synonym: "inhibition of immunoglobulin production" NARROW []
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
relationship: negatively_regulates GO:0002377 ! immunoglobulin production

[Term]
id: GO:0002639
name: positive regulation of immunoglobulin production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production." [GOC:add]
synonym: "activation of immunoglobulin production" NARROW []
synonym: "stimulation of immunoglobulin production" NARROW []
synonym: "up regulation of immunoglobulin production" EXACT []
synonym: "up-regulation of immunoglobulin production" EXACT []
synonym: "upregulation of immunoglobulin production" EXACT []
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
relationship: positively_regulates GO:0002377 ! immunoglobulin production

[Term]
id: GO:0002640
name: regulation of immunoglobulin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add]
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
relationship: regulates GO:0002378 ! immunoglobulin biosynthetic process

[Term]
id: GO:0002641
name: negative regulation of immunoglobulin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add]
synonym: "down regulation of immunoglobulin biosynthetic process" EXACT []
synonym: "down-regulation of immunoglobulin biosynthetic process" EXACT []
synonym: "downregulation of immunoglobulin biosynthetic process" EXACT []
synonym: "inhibition of immunoglobulin biosynthetic process" NARROW []
is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
relationship: negatively_regulates GO:0002378 ! immunoglobulin biosynthetic process

[Term]
id: GO:0002642
name: positive regulation of immunoglobulin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add]
synonym: "activation of immunoglobulin biosynthetic process" NARROW []
synonym: "stimulation of immunoglobulin biosynthetic process" NARROW []
synonym: "up regulation of immunoglobulin biosynthetic process" EXACT []
synonym: "up-regulation of immunoglobulin biosynthetic process" EXACT []
synonym: "upregulation of immunoglobulin biosynthetic process" EXACT []
is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
relationship: positively_regulates GO:0002378 ! immunoglobulin biosynthetic process

[Term]
id: GO:0002643
name: regulation of tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
relationship: regulates GO:0002507 ! tolerance induction

[Term]
id: GO:0002644
name: negative regulation of tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction." [GOC:add]
synonym: "down regulation of tolerance induction" EXACT []
synonym: "down-regulation of tolerance induction" EXACT []
synonym: "downregulation of tolerance induction" EXACT []
synonym: "inhibition of tolerance induction" NARROW []
is_a: GO:0002643 ! regulation of tolerance induction
is_a: GO:0002683 ! negative regulation of immune system process
relationship: negatively_regulates GO:0002507 ! tolerance induction

[Term]
id: GO:0002645
name: positive regulation of tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction." [GOC:add]
synonym: "activation of tolerance induction" NARROW []
synonym: "stimulation of tolerance induction" NARROW []
synonym: "up regulation of tolerance induction" EXACT []
synonym: "up-regulation of tolerance induction" EXACT []
synonym: "upregulation of tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
is_a: GO:0002684 ! positive regulation of immune system process
relationship: positively_regulates GO:0002507 ! tolerance induction

[Term]
id: GO:0002646
name: regulation of central tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of central tolerance induction." [GOC:add]
is_a: GO:0002643 ! regulation of tolerance induction
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0002508 ! central tolerance induction

[Term]
id: GO:0002647
name: negative regulation of central tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction." [GOC:add]
synonym: "down regulation of central tolerance induction" EXACT []
synonym: "down-regulation of central tolerance induction" EXACT []
synonym: "downregulation of central tolerance induction" EXACT []
synonym: "inhibition of central tolerance induction" NARROW []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002646 ! regulation of central tolerance induction
relationship: negatively_regulates GO:0002508 ! central tolerance induction

[Term]
id: GO:0002648
name: positive regulation of central tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of central tolerance induction." [GOC:add]
synonym: "activation of central tolerance induction" NARROW []
synonym: "stimulation of central tolerance induction" NARROW []
synonym: "up regulation of central tolerance induction" EXACT []
synonym: "up-regulation of central tolerance induction" EXACT []
synonym: "upregulation of central tolerance induction" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002646 ! regulation of central tolerance induction
relationship: positively_regulates GO:0002508 ! central tolerance induction

[Term]
id: GO:0002649
name: regulation of tolerance induction to self antigen
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add]
is_a: GO:0002643 ! regulation of tolerance induction
relationship: regulates GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002650
name: negative regulation of tolerance induction to self antigen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add]
synonym: "down regulation of tolerance induction to self antigen" EXACT []
synonym: "down-regulation of tolerance induction to self antigen" EXACT []
synonym: "downregulation of tolerance induction to self antigen" EXACT []
synonym: "inhibition of tolerance induction to self antigen" NARROW []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002649 ! regulation of tolerance induction to self antigen
relationship: negatively_regulates GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002651
name: positive regulation of tolerance induction to self antigen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add]
synonym: "activation of tolerance induction to self antigen" NARROW []
synonym: "stimulation of tolerance induction to self antigen" NARROW []
synonym: "up regulation of tolerance induction to self antigen" EXACT []
synonym: "up-regulation of tolerance induction to self antigen" EXACT []
synonym: "upregulation of tolerance induction to self antigen" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002649 ! regulation of tolerance induction to self antigen
relationship: positively_regulates GO:0002513 ! tolerance induction to self antigen

[Term]
id: GO:0002652
name: regulation of tolerance induction dependent upon immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add]
synonym: "regulation of immune response-dependent tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: regulates GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002653
name: negative regulation of tolerance induction dependent upon immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add]
synonym: "down regulation of tolerance induction dependent upon immune response" EXACT []
synonym: "down-regulation of tolerance induction dependent upon immune response" EXACT []
synonym: "downregulation of tolerance induction dependent upon immune response" EXACT []
synonym: "inhibition of tolerance induction dependent upon immune response" NARROW []
synonym: "negative regulation of immune response-dependent tolerance induction" EXACT []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002654
name: positive regulation of tolerance induction dependent upon immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add]
synonym: "activation of tolerance induction dependent upon immune response" NARROW []
synonym: "positive regulation of immune response-dependent tolerance induction" EXACT []
synonym: "stimulation of tolerance induction dependent upon immune response" NARROW []
synonym: "up regulation of tolerance induction dependent upon immune response" EXACT []
synonym: "up-regulation of tolerance induction dependent upon immune response" EXACT []
synonym: "upregulation of tolerance induction dependent upon immune response" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response

[Term]
id: GO:0002655
name: regulation of tolerance induction to nonself antigen
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add]
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
relationship: regulates GO:0002462 ! tolerance induction to nonself antigen

[Term]
id: GO:0002656
name: negative regulation of tolerance induction to nonself antigen
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add]
synonym: "down regulation of tolerance induction to nonself antigen" EXACT []
synonym: "down-regulation of tolerance induction to nonself antigen" EXACT []
synonym: "downregulation of tolerance induction to nonself antigen" EXACT []
synonym: "inhibition of tolerance induction to nonself antigen" NARROW []
is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response
is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen
relationship: negatively_regulates GO:0002462 ! tolerance induction to nonself antigen

[Term]
id: GO:0002657
name: positive regulation of tolerance induction to nonself antigen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add]
synonym: "activation of tolerance induction to nonself antigen" NARROW []
synonym: "stimulation of tolerance induction to nonself antigen" NARROW []
synonym: "up regulation of tolerance induction to nonself antigen" EXACT []
synonym: "up-regulation of tolerance induction to nonself antigen" EXACT []
synonym: "upregulation of tolerance induction to nonself antigen" EXACT []
is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response
is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen
relationship: positively_regulates GO:0002462 ! tolerance induction to nonself antigen

[Term]
id: GO:0002658
name: regulation of peripheral tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction." [GOC:add]
is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response
relationship: regulates GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002659
name: negative regulation of peripheral tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction." [GOC:add]
synonym: "down regulation of peripheral tolerance induction" EXACT []
synonym: "down-regulation of peripheral tolerance induction" EXACT []
synonym: "downregulation of peripheral tolerance induction" EXACT []
synonym: "inhibition of peripheral tolerance induction" NARROW []
is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response
is_a: GO:0002658 ! regulation of peripheral tolerance induction
relationship: negatively_regulates GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002660
name: positive regulation of peripheral tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction." [GOC:add]
synonym: "activation of peripheral tolerance induction" NARROW []
synonym: "stimulation of peripheral tolerance induction" NARROW []
synonym: "up regulation of peripheral tolerance induction" EXACT []
synonym: "up-regulation of peripheral tolerance induction" EXACT []
synonym: "upregulation of peripheral tolerance induction" EXACT []
is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response
is_a: GO:0002658 ! regulation of peripheral tolerance induction
relationship: positively_regulates GO:0002465 ! peripheral tolerance induction

[Term]
id: GO:0002661
name: regulation of B cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell tolerance induction." [GOC:add]
synonym: "regulation of B lymphocyte tolerance induction" EXACT []
synonym: "regulation of B-cell tolerance induction" EXACT []
synonym: "regulation of B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
relationship: regulates GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002662
name: negative regulation of B cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction." [GOC:add]
synonym: "down regulation of B cell tolerance induction" EXACT []
synonym: "down-regulation of B cell tolerance induction" EXACT []
synonym: "downregulation of B cell tolerance induction" EXACT []
synonym: "inhibition of B cell tolerance induction" NARROW []
synonym: "negative regulation of B lymphocyte tolerance induction" EXACT []
synonym: "negative regulation of B-cell tolerance induction" EXACT []
synonym: "negative regulation of B-lymphocyte tolerance induction" EXACT []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002661 ! regulation of B cell tolerance induction
relationship: negatively_regulates GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002663
name: positive regulation of B cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction." [GOC:add]
synonym: "activation of B cell tolerance induction" NARROW []
synonym: "positive regulation of B lymphocyte tolerance induction" EXACT []
synonym: "positive regulation of B-cell tolerance induction" EXACT []
synonym: "positive regulation of B-lymphocyte tolerance induction" EXACT []
synonym: "stimulation of B cell tolerance induction" NARROW []
synonym: "up regulation of B cell tolerance induction" EXACT []
synonym: "up-regulation of B cell tolerance induction" EXACT []
synonym: "upregulation of B cell tolerance induction" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002661 ! regulation of B cell tolerance induction
relationship: positively_regulates GO:0002514 ! B cell tolerance induction

[Term]
id: GO:0002664
name: regulation of T cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction." [GOC:add]
synonym: "regulation of T lymphocyte tolerance induction" EXACT []
synonym: "regulation of T-cell tolerance induction" EXACT []
synonym: "regulation of T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
relationship: regulates GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002665
name: negative regulation of T cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction." [GOC:add]
synonym: "down regulation of T cell tolerance induction" EXACT []
synonym: "down-regulation of T cell tolerance induction" EXACT []
synonym: "downregulation of T cell tolerance induction" EXACT []
synonym: "inhibition of T cell tolerance induction" NARROW []
synonym: "negative regulation of T lymphocyte tolerance induction" EXACT []
synonym: "negative regulation of T-cell tolerance induction" EXACT []
synonym: "negative regulation of T-lymphocyte tolerance induction" EXACT []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002664 ! regulation of T cell tolerance induction
relationship: negatively_regulates GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002666
name: positive regulation of T cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction." [GOC:add]
synonym: "activation of T cell tolerance induction" NARROW []
synonym: "positive regulation of T lymphocyte tolerance induction" EXACT []
synonym: "positive regulation of T-cell tolerance induction" EXACT []
synonym: "positive regulation of T-lymphocyte tolerance induction" EXACT []
synonym: "stimulation of T cell tolerance induction" NARROW []
synonym: "up regulation of T cell tolerance induction" EXACT []
synonym: "up-regulation of T cell tolerance induction" EXACT []
synonym: "upregulation of T cell tolerance induction" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002664 ! regulation of T cell tolerance induction
relationship: positively_regulates GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002667
name: regulation of T cell anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell anergy." [GOC:add]
synonym: "regulation of T lymphocyte anergy" EXACT []
synonym: "regulation of T-cell anergy" EXACT []
synonym: "regulation of T-lymphocyte anergy" EXACT []
is_a: GO:0002664 ! regulation of T cell tolerance induction
is_a: GO:0002911 ! regulation of lymphocyte anergy
relationship: regulates GO:0002870 ! T cell anergy

[Term]
id: GO:0002668
name: negative regulation of T cell anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy." [GOC:add]
synonym: "down regulation of T cell anergy" EXACT []
synonym: "down-regulation of T cell anergy" EXACT []
synonym: "downregulation of T cell anergy" EXACT []
synonym: "inhibition of T cell anergy" NARROW []
synonym: "negative regulation of T lymphocyte anergy" EXACT []
synonym: "negative regulation of T-cell anergy" EXACT []
synonym: "negative regulation of T-lymphocyte anergy" EXACT []
is_a: GO:0002665 ! negative regulation of T cell tolerance induction
is_a: GO:0002667 ! regulation of T cell anergy
is_a: GO:0002912 ! negative regulation of lymphocyte anergy
relationship: negatively_regulates GO:0002870 ! T cell anergy

[Term]
id: GO:0002669
name: positive regulation of T cell anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell anergy." [GOC:add]
synonym: "activation of T cell anergy" NARROW []
synonym: "positive regulation of T lymphocyte anergy" EXACT []
synonym: "positive regulation of T-cell anergy" EXACT []
synonym: "positive regulation of T-lymphocyte anergy" EXACT []
synonym: "stimulation of T cell anergy" NARROW []
synonym: "up regulation of T cell anergy" EXACT []
synonym: "up-regulation of T cell anergy" EXACT []
synonym: "upregulation of T cell anergy" EXACT []
is_a: GO:0002666 ! positive regulation of T cell tolerance induction
is_a: GO:0002667 ! regulation of T cell anergy
is_a: GO:0002913 ! positive regulation of lymphocyte anergy
relationship: positively_regulates GO:0002870 ! T cell anergy

[Term]
id: GO:0002670
name: regulation of B cell anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell anergy." [GOC:add]
synonym: "regulation of B lymphocyte anergy" EXACT []
synonym: "regulation of B-cell anergy" EXACT []
synonym: "regulation of B-lymphocyte anergy" EXACT []
is_a: GO:0002661 ! regulation of B cell tolerance induction
is_a: GO:0002911 ! regulation of lymphocyte anergy
relationship: regulates GO:0002515 ! B cell anergy

[Term]
id: GO:0002671
name: negative regulation of B cell anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy." [GOC:add]
synonym: "down regulation of B cell anergy" EXACT []
synonym: "down-regulation of B cell anergy" EXACT []
synonym: "downregulation of B cell anergy" EXACT []
synonym: "inhibition of B cell anergy" NARROW []
synonym: "negative regulation of B lymphocyte anergy" EXACT []
synonym: "negative regulation of B-cell anergy" EXACT []
synonym: "negative regulation of B-lymphocyte anergy" EXACT []
is_a: GO:0002662 ! negative regulation of B cell tolerance induction
is_a: GO:0002670 ! regulation of B cell anergy
is_a: GO:0002912 ! negative regulation of lymphocyte anergy
relationship: negatively_regulates GO:0002515 ! B cell anergy

[Term]
id: GO:0002672
name: positive regulation of B cell anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell anergy." [GOC:add]
synonym: "activation of B cell anergy" NARROW []
synonym: "positive regulation of B lymphocyte anergy" EXACT []
synonym: "positive regulation of B-cell anergy" EXACT []
synonym: "positive regulation of B-lymphocyte anergy" EXACT []
synonym: "stimulation of B cell anergy" NARROW []
synonym: "up regulation of B cell anergy" EXACT []
synonym: "up-regulation of B cell anergy" EXACT []
synonym: "upregulation of B cell anergy" EXACT []
is_a: GO:0002663 ! positive regulation of B cell tolerance induction
is_a: GO:0002670 ! regulation of B cell anergy
is_a: GO:0002913 ! positive regulation of lymphocyte anergy
relationship: positively_regulates GO:0002515 ! B cell anergy

[Term]
id: GO:0002673
name: regulation of acute inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response." [GOC:add]
is_a: GO:0050727 ! regulation of inflammatory response
relationship: regulates GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002674
name: negative regulation of acute inflammatory response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response." [GOC:add]
synonym: "down regulation of acute inflammatory response" EXACT []
synonym: "down-regulation of acute inflammatory response" EXACT []
synonym: "downregulation of acute inflammatory response" EXACT []
synonym: "inhibition of acute inflammatory response" NARROW []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0050728 ! negative regulation of inflammatory response
relationship: negatively_regulates GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002675
name: positive regulation of acute inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response." [GOC:add]
synonym: "activation of acute inflammatory response" NARROW []
synonym: "stimulation of acute inflammatory response" NARROW []
synonym: "up regulation of acute inflammatory response" EXACT []
synonym: "up-regulation of acute inflammatory response" EXACT []
synonym: "upregulation of acute inflammatory response" EXACT []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0050729 ! positive regulation of inflammatory response
relationship: positively_regulates GO:0002526 ! acute inflammatory response

[Term]
id: GO:0002676
name: regulation of chronic inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response." [GOC:add]
is_a: GO:0050727 ! regulation of inflammatory response
relationship: regulates GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002677
name: negative regulation of chronic inflammatory response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response." [GOC:add]
synonym: "down regulation of chronic inflammatory response" EXACT []
synonym: "down-regulation of chronic inflammatory response" EXACT []
synonym: "downregulation of chronic inflammatory response" EXACT []
synonym: "inhibition of chronic inflammatory response" NARROW []
is_a: GO:0002676 ! regulation of chronic inflammatory response
is_a: GO:0050728 ! negative regulation of inflammatory response
relationship: negatively_regulates GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002678
name: positive regulation of chronic inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response." [GOC:add]
synonym: "activation of chronic inflammatory response" NARROW []
synonym: "stimulation of chronic inflammatory response" NARROW []
synonym: "up regulation of chronic inflammatory response" EXACT []
synonym: "up-regulation of chronic inflammatory response" EXACT []
synonym: "upregulation of chronic inflammatory response" EXACT []
is_a: GO:0002676 ! regulation of chronic inflammatory response
is_a: GO:0050729 ! positive regulation of inflammatory response
relationship: positively_regulates GO:0002544 ! chronic inflammatory response

[Term]
id: GO:0002679
name: respiratory burst during defense response
namespace: biological_process
def: "A phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12789499]
is_a: GO:0002252 ! immune effector process
is_a: GO:0045087 ! innate immune response
is_a: GO:0045730 ! respiratory burst

[Term]
id: GO:0002680
name: pro-T cell lineage commitment
namespace: biological_process
def: "The process by which a lymphoid progenitor cell becomes committed to becoming a pro-T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "pro-T cell fate commitment" EXACT []
synonym: "pro-T lymphocyte fate commitment" EXACT []
synonym: "pro-T lymphocyte lineage commitment" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0002572 ! pro-T cell differentiation

[Term]
id: GO:0002681
name: somatic recombination of T cell receptor gene segments
namespace: biological_process
def: "The process by which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "somatic recombination of TCR gene segments" EXACT []
is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus
is_a: GO:0002568 ! somatic diversification of T cell receptor genes

[Term]
id: GO:0002682
name: regulation of immune system process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0002376 ! immune system process

[Term]
id: GO:0002683
name: negative regulation of immune system process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]
synonym: "down regulation of immune system process" EXACT []
synonym: "down-regulation of immune system process" EXACT []
synonym: "downregulation of immune system process" EXACT []
synonym: "inhibition of immune system process" NARROW []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0002376 ! immune system process

[Term]
id: GO:0002684
name: positive regulation of immune system process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]
synonym: "activation of immune system process" NARROW []
synonym: "stimulation of immune system process" NARROW []
synonym: "up regulation of immune system process" EXACT []
synonym: "up-regulation of immune system process" EXACT []
synonym: "upregulation of immune system process" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0002376 ! immune system process

[Term]
id: GO:0002685
name: regulation of leukocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "regulation of immune cell migration" EXACT []
synonym: "regulation of leucocyte migration" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0050900 ! leukocyte migration

[Term]
id: GO:0002686
name: negative regulation of leukocyte migration
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "down regulation of leukocyte migration" EXACT []
synonym: "down-regulation of leukocyte migration" EXACT []
synonym: "downregulation of leukocyte migration" EXACT []
synonym: "inhibition of leukocyte migration" NARROW []
synonym: "negative regulation of immune cell migration" EXACT []
synonym: "negative regulation of leucocyte migration" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0030336 ! negative regulation of cell migration
relationship: negatively_regulates GO:0050900 ! leukocyte migration

[Term]
id: GO:0002687
name: positive regulation of leukocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add]
synonym: "activation of leukocyte migration" NARROW []
synonym: "positive regulation of immune cell migration" EXACT []
synonym: "positive regulation of leucocyte migration" EXACT []
synonym: "stimulation of leukocyte migration" NARROW []
synonym: "up regulation of leukocyte migration" EXACT []
synonym: "up-regulation of leukocyte migration" EXACT []
synonym: "upregulation of leukocyte migration" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0030335 ! positive regulation of cell migration
relationship: positively_regulates GO:0050900 ! leukocyte migration

[Term]
id: GO:0002688
name: regulation of leukocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "regulation of immune cell chemotaxis" EXACT []
synonym: "regulation of leucocyte chemotaxis" EXACT []
is_a: GO:0002685 ! regulation of leukocyte migration
is_a: GO:0050920 ! regulation of chemotaxis
relationship: regulates GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002689
name: negative regulation of leukocyte chemotaxis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "down regulation of leukocyte chemotaxis" EXACT []
synonym: "down-regulation of leukocyte chemotaxis" EXACT []
synonym: "downregulation of leukocyte chemotaxis" EXACT []
synonym: "inhibition of leukocyte chemotaxis" NARROW []
synonym: "negative regulation of immune cell chemotaxis" EXACT []
synonym: "negative regulation of leucocyte chemotaxis" EXACT []
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0050922 ! negative regulation of chemotaxis
relationship: negatively_regulates GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002690
name: positive regulation of leukocyte chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]
synonym: "activation of leukocyte chemotaxis" NARROW []
synonym: "positive regulation of immune cell chemotaxis" EXACT []
synonym: "positive regulation of leucocyte chemotaxis" EXACT []
synonym: "stimulation of leukocyte chemotaxis" NARROW []
synonym: "up regulation of leukocyte chemotaxis" EXACT []
synonym: "up-regulation of leukocyte chemotaxis" EXACT []
synonym: "upregulation of leukocyte chemotaxis" EXACT []
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
is_a: GO:0050921 ! positive regulation of chemotaxis
relationship: positively_regulates GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0002691
name: regulation of cellular extravasation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cellular extravasation." [GOC:add]
is_a: GO:0002685 ! regulation of leukocyte migration
relationship: regulates GO:0045123 ! cellular extravasation

[Term]
id: GO:0002692
name: negative regulation of cellular extravasation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation." [GOC:add]
synonym: "down regulation of cellular extravasation" EXACT []
synonym: "down-regulation of cellular extravasation" EXACT []
synonym: "downregulation of cellular extravasation" EXACT []
synonym: "inhibition of cellular extravasation" NARROW []
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:0002691 ! regulation of cellular extravasation
relationship: negatively_regulates GO:0045123 ! cellular extravasation

[Term]
id: GO:0002693
name: positive regulation of cellular extravasation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cellular extravasation." [GOC:add]
synonym: "activation of cellular extravasation" NARROW []
synonym: "stimulation of cellular extravasation" NARROW []
synonym: "up regulation of cellular extravasation" EXACT []
synonym: "up-regulation of cellular extravasation" EXACT []
synonym: "upregulation of cellular extravasation" EXACT []
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:0002691 ! regulation of cellular extravasation
relationship: positively_regulates GO:0045123 ! cellular extravasation

[Term]
id: GO:0002694
name: regulation of leukocyte activation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "regulation of immune cell activation" EXACT []
synonym: "regulation of leucocyte activation" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0050865 ! regulation of cell activation
relationship: regulates GO:0045321 ! leukocyte activation

[Term]
id: GO:0002695
name: negative regulation of leukocyte activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "down regulation of leukocyte activation" EXACT []
synonym: "down-regulation of leukocyte activation" EXACT []
synonym: "downregulation of leukocyte activation" EXACT []
synonym: "inhibition of leukocyte activation" NARROW []
synonym: "negative regulation of immune cell activation" EXACT []
synonym: "negative regulation of leucocyte activation" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0050866 ! negative regulation of cell activation
relationship: negatively_regulates GO:0045321 ! leukocyte activation

[Term]
id: GO:0002696
name: positive regulation of leukocyte activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add]
synonym: "activation of leukocyte activation" NARROW []
synonym: "positive regulation of immune cell activation" EXACT []
synonym: "positive regulation of leucocyte activation" EXACT []
synonym: "stimulation of leukocyte activation" NARROW []
synonym: "up regulation of leukocyte activation" EXACT []
synonym: "up-regulation of leukocyte activation" EXACT []
synonym: "upregulation of leukocyte activation" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0050867 ! positive regulation of cell activation
relationship: positively_regulates GO:0045321 ! leukocyte activation

[Term]
id: GO:0002697
name: regulation of immune effector process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add]
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002252 ! immune effector process

[Term]
id: GO:0002698
name: negative regulation of immune effector process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add]
synonym: "down regulation of immune effector process" EXACT []
synonym: "down-regulation of immune effector process" EXACT []
synonym: "downregulation of immune effector process" EXACT []
synonym: "inhibition of immune effector process" NARROW []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0002697 ! regulation of immune effector process
relationship: negatively_regulates GO:0002252 ! immune effector process

[Term]
id: GO:0002699
name: positive regulation of immune effector process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add]
synonym: "activation of immune effector process" NARROW []
synonym: "stimulation of immune effector process" NARROW []
synonym: "up regulation of immune effector process" EXACT []
synonym: "up-regulation of immune effector process" EXACT []
synonym: "upregulation of immune effector process" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0002697 ! regulation of immune effector process
relationship: positively_regulates GO:0002252 ! immune effector process

[Term]
id: GO:0002700
name: regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
is_a: GO:0002697 ! regulation of immune effector process
relationship: regulates GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002701
name: negative regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
synonym: "down regulation of production of molecular mediator of immune response" EXACT []
synonym: "down-regulation of production of molecular mediator of immune response" EXACT []
synonym: "downregulation of production of molecular mediator of immune response" EXACT []
synonym: "inhibition of production of molecular mediator of immune response" NARROW []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
relationship: negatively_regulates GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002702
name: positive regulation of production of molecular mediator of immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]
synonym: "activation of production of molecular mediator of immune response" NARROW []
synonym: "stimulation of production of molecular mediator of immune response" NARROW []
synonym: "up regulation of production of molecular mediator of immune response" EXACT []
synonym: "up-regulation of production of molecular mediator of immune response" EXACT []
synonym: "upregulation of production of molecular mediator of immune response" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
relationship: positively_regulates GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0002703
name: regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "regulation of immune cell mediated immunity" EXACT []
synonym: "regulation of leucocyte mediated immunity" EXACT []
is_a: GO:0002697 ! regulation of immune effector process
relationship: regulates GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002704
name: negative regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "down regulation of leukocyte mediated immunity" EXACT []
synonym: "down-regulation of leukocyte mediated immunity" EXACT []
synonym: "downregulation of leukocyte mediated immunity" EXACT []
synonym: "inhibition of leukocyte mediated immunity" NARROW []
synonym: "negative regulation of immune cell mediated immunity" EXACT []
synonym: "negative regulation of leucocyte mediated immunity" EXACT []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
relationship: negatively_regulates GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002705
name: positive regulation of leukocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]
synonym: "activation of leukocyte mediated immunity" NARROW []
synonym: "positive regulation of immune cell mediated immunity" EXACT []
synonym: "positive regulation of leucocyte mediated immunity" EXACT []
synonym: "stimulation of leukocyte mediated immunity" NARROW []
synonym: "up regulation of leukocyte mediated immunity" EXACT []
synonym: "up-regulation of leukocyte mediated immunity" EXACT []
synonym: "upregulation of leukocyte mediated immunity" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
relationship: positively_regulates GO:0002443 ! leukocyte mediated immunity

[Term]
id: GO:0002706
name: regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
relationship: regulates GO:0002449 ! lymphocyte mediated immunity

[Term]
id: GO:0002707
name: negative regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
synonym: "down regulation of lymphocyte mediated immunity" EXACT []
synonym: "down-regulation of lymphocyte mediated immunity" EXACT []
synonym: "downregulation of lymphocyte mediated immunity" EXACT []
synonym: "inhibition of lymphocyte mediated immunity" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
relationship: negatively_regulates GO:0002449 ! lymphocyte mediated immunity

[Term]
id: GO:0002708
name: positive regulation of lymphocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]
synonym: "activation of lymphocyte mediated immunity" NARROW []
synonym: "stimulation of lymphocyte mediated immunity" NARROW []
synonym: "up regulation of lymphocyte mediated immunity" EXACT []
synonym: "up-regulation of lymphocyte mediated immunity" EXACT []
synonym: "upregulation of lymphocyte mediated immunity" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
relationship: positively_regulates GO:0002449 ! lymphocyte mediated immunity

[Term]
id: GO:0002709
name: regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "regulation of T lymphocyte mediated immunity" EXACT []
synonym: "regulation of T-cell mediated immunity" EXACT []
synonym: "regulation of T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: regulates GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002710
name: negative regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "down regulation of T cell mediated immunity" EXACT []
synonym: "down-regulation of T cell mediated immunity" EXACT []
synonym: "downregulation of T cell mediated immunity" EXACT []
synonym: "inhibition of T cell mediated immunity" NARROW []
synonym: "negative regulation of T lymphocyte mediated immunity" EXACT []
synonym: "negative regulation of T-cell mediated immunity" EXACT []
synonym: "negative regulation of T-lymphocyte mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: negatively_regulates GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002711
name: positive regulation of T cell mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add]
synonym: "activation of T cell mediated immunity" NARROW []
synonym: "positive regulation of T lymphocyte mediated immunity" EXACT []
synonym: "positive regulation of T-cell mediated immunity" EXACT []
synonym: "positive regulation of T-lymphocyte mediated immunity" EXACT []
synonym: "stimulation of T cell mediated immunity" NARROW []
synonym: "up regulation of T cell mediated immunity" EXACT []
synonym: "up-regulation of T cell mediated immunity" EXACT []
synonym: "upregulation of T cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: positively_regulates GO:0002456 ! T cell mediated immunity

[Term]
id: GO:0002712
name: regulation of B cell mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell mediated immunity." [GOC:add]
synonym: "regulation of B lymphocyte mediated immunity" EXACT []
synonym: "regulation of B-cell mediated immunity" EXACT []
synonym: "regulation of B-lymphocyte mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: regulates GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002713
name: negative regulation of B cell mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." [GOC:add]
synonym: "down regulation of B cell mediated immunity" EXACT []
synonym: "down-regulation of B cell mediated immunity" EXACT []
synonym: "downregulation of B cell mediated immunity" EXACT []
synonym: "inhibition of B cell mediated immunity" NARROW []
synonym: "negative regulation of B lymphocyte mediated immunity" EXACT []
synonym: "negative regulation of B-cell mediated immunity" EXACT []
synonym: "negative regulation of B-lymphocyte mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: negatively_regulates GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002714
name: positive regulation of B cell mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." [GOC:add]
synonym: "activation of B cell mediated immunity" NARROW []
synonym: "positive regulation of B lymphocyte mediated immunity" EXACT []
synonym: "positive regulation of B-cell mediated immunity" EXACT []
synonym: "positive regulation of B-lymphocyte mediated immunity" EXACT []
synonym: "stimulation of B cell mediated immunity" NARROW []
synonym: "up regulation of B cell mediated immunity" EXACT []
synonym: "up-regulation of B cell mediated immunity" EXACT []
synonym: "upregulation of B cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: positively_regulates GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0002715
name: regulation of natural killer cell mediated immunity
namespace: biological_process
alt_id: GO:0045845
def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]
synonym: "regulation of natural killer cell activity" RELATED []
synonym: "regulation of NK cell mediated immunity" EXACT []
is_a: GO:0002706 ! regulation of lymphocyte mediated immunity
is_a: GO:0045088 ! regulation of innate immune response
relationship: regulates GO:0002228 ! natural killer cell mediated immunity

[Term]
id: GO:0002716
name: negative regulation of natural killer cell mediated immunity
namespace: biological_process
alt_id: GO:0030102
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]
synonym: "down regulation of natural killer cell mediated immunity" EXACT []
synonym: "down-regulation of natural killer cell mediated immunity" EXACT []
synonym: "downregulation of natural killer cell mediated immunity" EXACT []
synonym: "inhibition of natural killer cell mediated immunity" NARROW []
synonym: "negative regulation of natural killer cell activity" RELATED []
synonym: "negative regulation of NK cell activity" RELATED []
synonym: "negative regulation of NK cell mediated immunity" EXACT []
is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0045824 ! negative regulation of innate immune response
relationship: negatively_regulates GO:0002228 ! natural killer cell mediated immunity

[Term]
id: GO:0002717
name: positive regulation of natural killer cell mediated immunity
namespace: biological_process
alt_id: GO:0045846
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]
synonym: "activation of natural killer cell mediated immunity" NARROW []
synonym: "positive regulation of natural killer cell activity" RELATED []
synonym: "positive regulation of NK cell activity" RELATED []
synonym: "positive regulation of NK cell mediated immunity" EXACT []
synonym: "stimulation of natural killer cell mediated immunity" NARROW []
synonym: "up regulation of natural killer cell mediated immunity" EXACT []
synonym: "up-regulation of natural killer cell mediated immunity" EXACT []
synonym: "upregulation of natural killer cell mediated immunity" EXACT []
is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0045089 ! positive regulation of innate immune response
relationship: positively_regulates GO:0002228 ! natural killer cell mediated immunity

[Term]
id: GO:0002718
name: regulation of cytokine production during immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cytokine production during immune response." [GOC:add]
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
relationship: regulates GO:0002367 ! cytokine production during immune response

[Term]
id: GO:0002719
name: negative regulation of cytokine production during immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production during an immune response." [GOC:add]
synonym: "down regulation of cytokine production during immune response" EXACT []
synonym: "down-regulation of cytokine production during immune response" EXACT []
synonym: "downregulation of cytokine production during immune response" EXACT []
synonym: "inhibition of cytokine production during immune response" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:0002718 ! regulation of cytokine production during immune response
relationship: negatively_regulates GO:0002367 ! cytokine production during immune response

[Term]
id: GO:0002720
name: positive regulation of cytokine production during immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cytokine production during immune response." [GOC:add]
synonym: "activation of cytokine production during immune response" NARROW []
synonym: "stimulation of cytokine production during immune response" NARROW []
synonym: "up regulation of cytokine production during immune response" EXACT []
synonym: "up-regulation of cytokine production during immune response" EXACT []
synonym: "upregulation of cytokine production during immune response" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:0002718 ! regulation of cytokine production during immune response
relationship: positively_regulates GO:0002367 ! cytokine production during immune response

[Term]
id: GO:0002721
name: regulation of B cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell cytokine production." [GOC:add]
synonym: "regulation of B lymphocyte cytokine production" EXACT []
synonym: "regulation of B-cell cytokine production" EXACT []
synonym: "regulation of B-lymphocyte cytokine production" EXACT []
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production during immune response
relationship: regulates GO:0002368 ! B cell cytokine production

[Term]
id: GO:0002722
name: negative regulation of B cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production." [GOC:add]
synonym: "down regulation of B cell cytokine production" EXACT []
synonym: "down-regulation of B cell cytokine production" EXACT []
synonym: "downregulation of B cell cytokine production" EXACT []
synonym: "inhibition of B cell cytokine production" NARROW []
synonym: "negative regulation of B lymphocyte cytokine production" EXACT []
synonym: "negative regulation of B-cell cytokine production" EXACT []
synonym: "negative regulation of B-lymphocyte cytokine production" EXACT []
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production during immune response
is_a: GO:0002721 ! regulation of B cell cytokine production
relationship: negatively_regulates GO:0002368 ! B cell cytokine production

[Term]
id: GO:0002723
name: positive regulation of B cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell cytokine production." [GOC:add]
synonym: "activation of B cell cytokine production" NARROW []
synonym: "positive regulation of B lymphocyte cytokine production" EXACT []
synonym: "positive regulation of B-cell cytokine production" EXACT []
synonym: "positive regulation of B-lymphocyte cytokine production" EXACT []
synonym: "stimulation of B cell cytokine production" NARROW []
synonym: "up regulation of B cell cytokine production" EXACT []
synonym: "up-regulation of B cell cytokine production" EXACT []
synonym: "upregulation of B cell cytokine production" EXACT []
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production during immune response
is_a: GO:0002721 ! regulation of B cell cytokine production
relationship: positively_regulates GO:0002368 ! B cell cytokine production

[Term]
id: GO:0002724
name: regulation of T cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "regulation of T lymphocyte cytokine production" EXACT []
synonym: "regulation of T-cell cytokine production" EXACT []
synonym: "regulation of T-lymphocyte cytokine production" EXACT []
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production during immune response
relationship: regulates GO:0002369 ! T cell cytokine production

[Term]
id: GO:0002725
name: negative regulation of T cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "down regulation of T cell cytokine production" EXACT []
synonym: "down-regulation of T cell cytokine production" EXACT []
synonym: "downregulation of T cell cytokine production" EXACT []
synonym: "inhibition of T cell cytokine production" NARROW []
synonym: "negative regulation of T lymphocyte cytokine production" EXACT []
synonym: "negative regulation of T-cell cytokine production" EXACT []
synonym: "negative regulation of T-lymphocyte cytokine production" EXACT []
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production during immune response
is_a: GO:0002724 ! regulation of T cell cytokine production
relationship: negatively_regulates GO:0002369 ! T cell cytokine production

[Term]
id: GO:0002726
name: positive regulation of T cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add]
synonym: "activation of T cell cytokine production" NARROW []
synonym: "positive regulation of T lymphocyte cytokine production" EXACT []
synonym: "positive regulation of T-cell cytokine production" EXACT []
synonym: "positive regulation of T-lymphocyte cytokine production" EXACT []
synonym: "stimulation of T cell cytokine production" NARROW []
synonym: "up regulation of T cell cytokine production" EXACT []
synonym: "up-regulation of T cell cytokine production" EXACT []
synonym: "upregulation of T cell cytokine production" EXACT []
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production during immune response
is_a: GO:0002724 ! regulation of T cell cytokine production
relationship: positively_regulates GO:0002369 ! T cell cytokine production

[Term]
id: GO:0002727
name: regulation of natural killer cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]
synonym: "regulation of NK cell cytokine production" EXACT []
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0002718 ! regulation of cytokine production during immune response
relationship: regulates GO:0002370 ! natural killer cell cytokine production

[Term]
id: GO:0002728
name: negative regulation of natural killer cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]
synonym: "down regulation of natural killer cell cytokine production" EXACT []
synonym: "down-regulation of natural killer cell cytokine production" EXACT []
synonym: "downregulation of natural killer cell cytokine production" EXACT []
synonym: "inhibition of natural killer cell cytokine production" NARROW []
synonym: "negative regulation of NK cell cytokine production" EXACT []
is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity
is_a: GO:0002719 ! negative regulation of cytokine production during immune response
is_a: GO:0002727 ! regulation of natural killer cell cytokine production
relationship: negatively_regulates GO:0002370 ! natural killer cell cytokine production

[Term]
id: GO:0002729
name: positive regulation of natural killer cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]
synonym: "activation of natural killer cell cytokine production" NARROW []
synonym: "positive regulation of NK cell cytokine production" EXACT []
synonym: "stimulation of natural killer cell cytokine production" NARROW []
synonym: "up regulation of natural killer cell cytokine production" EXACT []
synonym: "up-regulation of natural killer cell cytokine production" EXACT []
synonym: "upregulation of natural killer cell cytokine production" EXACT []
is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity
is_a: GO:0002720 ! positive regulation of cytokine production during immune response
is_a: GO:0002727 ! regulation of natural killer cell cytokine production
relationship: positively_regulates GO:0002370 ! natural killer cell cytokine production

[Term]
id: GO:0002730
name: regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
is_a: GO:0002718 ! regulation of cytokine production during immune response
relationship: regulates GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002731
name: negative regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of dendritic cell cytokine production" EXACT []
synonym: "down-regulation of dendritic cell cytokine production" EXACT []
synonym: "downregulation of dendritic cell cytokine production" EXACT []
synonym: "inhibition of dendritic cell cytokine production" NARROW []
is_a: GO:0002719 ! negative regulation of cytokine production during immune response
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
relationship: negatively_regulates GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002732
name: positive regulation of dendritic cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]
synonym: "activation of dendritic cell cytokine production" NARROW []
synonym: "stimulation of dendritic cell cytokine production" NARROW []
synonym: "up regulation of dendritic cell cytokine production" EXACT []
synonym: "up-regulation of dendritic cell cytokine production" EXACT []
synonym: "upregulation of dendritic cell cytokine production" EXACT []
is_a: GO:0002720 ! positive regulation of cytokine production during immune response
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
relationship: positively_regulates GO:0002371 ! dendritic cell cytokine production

[Term]
id: GO:0002733
name: regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
relationship: regulates GO:0002372 ! myeloid dendritic cell cytokine production

[Term]
id: GO:0002734
name: negative regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "down-regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "downregulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "inhibition of myeloid dendritic cell cytokine production" NARROW []
is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production
is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production
relationship: negatively_regulates GO:0002372 ! myeloid dendritic cell cytokine production

[Term]
id: GO:0002735
name: positive regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]
synonym: "activation of myeloid dendritic cell cytokine production" NARROW []
synonym: "stimulation of myeloid dendritic cell cytokine production" NARROW []
synonym: "up regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "up-regulation of myeloid dendritic cell cytokine production" EXACT []
synonym: "upregulation of myeloid dendritic cell cytokine production" EXACT []
is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production
is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production
relationship: positively_regulates GO:0002372 ! myeloid dendritic cell cytokine production

[Term]
id: GO:0002736
name: regulation of plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add]
is_a: GO:0002730 ! regulation of dendritic cell cytokine production
relationship: regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production

[Term]
id: GO:0002737
name: negative regulation of plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add]
synonym: "down regulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "down-regulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "downregulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "inhibition of plasmacytoid dendritic cell cytokine production" NARROW []
is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production
is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production
relationship: negatively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production

[Term]
id: GO:0002738
name: positive regulation of plasmacytoid dendritic cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add]
synonym: "activation of plasmacytoid dendritic cell cytokine production" NARROW []
synonym: "stimulation of plasmacytoid dendritic cell cytokine production" NARROW []
synonym: "up regulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "up-regulation of plasmacytoid dendritic cell cytokine production" EXACT []
synonym: "upregulation of plasmacytoid dendritic cell cytokine production" EXACT []
is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production
is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production
relationship: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production

[Term]
id: GO:0002739
name: regulation of cytokine secretion during immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cytokine secretion during immune response." [GOC:add]
is_a: GO:0002718 ! regulation of cytokine production during immune response
is_a: GO:0050707 ! regulation of cytokine secretion
relationship: regulates GO:0002374 ! cytokine secretion during immune response

[Term]
id: GO:0002740
name: negative regulation of cytokine secretion during immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion during immune response." [GOC:add]
synonym: "down regulation of cytokine secretion during immune response" EXACT []
synonym: "down-regulation of cytokine secretion during immune response" EXACT []
synonym: "downregulation of cytokine secretion during immune response" EXACT []
synonym: "inhibition of cytokine secretion during immune response" NARROW []
is_a: GO:0002739 ! regulation of cytokine secretion during immune response
is_a: GO:0050710 ! negative regulation of cytokine secretion
relationship: negatively_regulates GO:0002374 ! cytokine secretion during immune response

[Term]
id: GO:0002741
name: positive regulation of cytokine secretion during immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cytokine secretion during immune response." [GOC:add]
synonym: "activation of cytokine secretion during immune response" NARROW []
synonym: "stimulation of cytokine secretion during immune response" NARROW []
synonym: "up regulation of cytokine secretion during immune response" EXACT []
synonym: "up-regulation of cytokine secretion during immune response" EXACT []
synonym: "upregulation of cytokine secretion during immune response" EXACT []
is_a: GO:0002739 ! regulation of cytokine secretion during immune response
is_a: GO:0050715 ! positive regulation of cytokine secretion
relationship: positively_regulates GO:0002374 ! cytokine secretion during immune response

[Term]
id: GO:0002742
name: regulation of cytokine biosynthetic process during immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cytokine biosynthesis during immune response." [GOC:add]
is_a: GO:0002718 ! regulation of cytokine production during immune response
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0002375 ! cytokine biosynthetic process during immune response

[Term]
id: GO:0002743
name: negative regulation of cytokine biosynthetic process during immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine biosynthesis during immune response." [GOC:add]
synonym: "down regulation of cytokine biosynthetic process during immune response" EXACT []
synonym: "down-regulation of cytokine biosynthetic process during immune response" EXACT []
synonym: "downregulation of cytokine biosynthetic process during immune response" EXACT []
synonym: "inhibition of cytokine biosynthetic process during immune response" NARROW []
is_a: GO:0002742 ! regulation of cytokine biosynthetic process during immune response
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
relationship: negatively_regulates GO:0002375 ! cytokine biosynthetic process during immune response

[Term]
id: GO:0002744
name: positive regulation of cytokine biosynthetic process during immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cytokine biosynthesis during immune response." [GOC:add]
synonym: "activation of cytokine biosynthetic process during immune response" NARROW []
synonym: "stimulation of cytokine biosynthetic process during immune response" NARROW []
synonym: "up regulation of cytokine biosynthetic process during immune response" EXACT []
synonym: "up-regulation of cytokine biosynthetic process during immune response" EXACT []
synonym: "upregulation of cytokine biosynthetic process during immune response" EXACT []
is_a: GO:0002742 ! regulation of cytokine biosynthetic process during immune response
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
relationship: positively_regulates GO:0002375 ! cytokine biosynthetic process during immune response

[Term]
id: GO:0002745
name: antigen processing and presentation initiated by receptor mediated uptake of antigen
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002746
name: antigen processing and presentation following pinocytosis
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002747
name: antigen processing and presentation following phagocytosis
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0002748
name: antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR)." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen" EXACT []
synonym: "antigen processing and presentation initiated by PRR mediated uptake of antigen" EXACT []
is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen

[Term]
id: GO:0002749
name: antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen
namespace: biological_process
def: "Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR)." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15596122]
synonym: "antigen processing and presentation initiated by TLR mediated phagocytosis of antigen" EXACT []
is_a: GO:0002747 ! antigen processing and presentation following phagocytosis
is_a: GO:0002748 ! antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen

[Term]
id: GO:0002750
name: antigen processing and presentation following macropinocytosis
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis." [GOC:add, PMID:16556257]
is_a: GO:0002746 ! antigen processing and presentation following pinocytosis

[Term]
id: GO:0002751
name: antigen processing and presentation following receptor mediated endocytosis
namespace: biological_process
def: "Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen

[Term]
id: GO:0002752
name: cell surface pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a cell surface pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967]
synonym: "cell surface PAMP receptor signaling pathway" EXACT []
synonym: "cell surface pathogen receptor signaling pathway" EXACT []
synonym: "cell surface pattern recognition receptor signalling pathway" EXACT []
synonym: "cell surface PRR signaling pathway" EXACT []
is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway
is_a: GO:0002221 ! pattern recognition receptor signaling pathway

[Term]
id: GO:0002753
name: cytoplasmic pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a cytoplasmic pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967]
synonym: "cytoplasmic PAMP receptor signaling pathway" EXACT []
synonym: "cytoplasmic pathogen receptor signaling pathway" EXACT []
synonym: "cytoplasmic pattern recognition receptor signalling pathway" EXACT []
synonym: "cytoplasmic PRR signaling pathway" EXACT []
is_a: GO:0002221 ! pattern recognition receptor signaling pathway

[Term]
id: GO:0002754
name: intracellular vesicle pattern recognition receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a pattern recognition receptor (PRR) located within the membrane of an intracellular vesicle such as an endosome or lysosome. Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967]
synonym: "intracellular vesicle PAMP receptor signaling pathway" EXACT []
synonym: "intracellular vesicle pathogen receptor signaling pathway" EXACT []
synonym: "intracellular vesicle pattern recognition receptor signalling pathway" EXACT []
synonym: "intracellular vesicle PRR signaling pathway" EXACT []
is_a: GO:0002221 ! pattern recognition receptor signaling pathway

[Term]
id: GO:0002755
name: MyD88-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor and relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
synonym: "MyD88-dependent TLR signaling pathway" EXACT []
synonym: "MyD88-dependent toll-like receptor signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0002756
name: MyD88-independent toll-like receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
synonym: "MyD88-independent TLR signaling pathway" EXACT []
synonym: "MyD88-independent toll-like receptor signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0002757
name: immune response-activating signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response." [GOC:add]
is_a: GO:0002253 ! activation of immune response
is_a: GO:0002764 ! immune response-regulating signaling pathway

[Term]
id: GO:0002758
name: innate immune response-activating signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
comment: This term was added by GO_REF:0000022.
is_a: GO:0002218 ! activation of innate immune response
is_a: GO:0002757 ! immune response-activating signal transduction

[Term]
id: GO:0002759
name: regulation of antimicrobial humoral response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0043900 ! regulation of multi-organism process
relationship: regulates GO:0019730 ! antimicrobial humoral response

[Term]
id: GO:0002760
name: positive regulation of antimicrobial humoral response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add]
synonym: "activation of antimicrobial humoral response" NARROW []
synonym: "stimulation of antimicrobial humoral response" NARROW []
synonym: "up regulation of antimicrobial humoral response" EXACT []
synonym: "up-regulation of antimicrobial humoral response" EXACT []
synonym: "upregulation of antimicrobial humoral response" EXACT []
is_a: GO:0002759 ! regulation of antimicrobial humoral response
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0002922 ! positive regulation of humoral immune response
is_a: GO:0043902 ! positive regulation of multi-organism process
relationship: positively_regulates GO:0019730 ! antimicrobial humoral response

[Term]
id: GO:0002761
name: regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
is_a: GO:0045637 ! regulation of myeloid cell differentiation
relationship: regulates GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0002762
name: negative regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
synonym: "down regulation of myeloid leukocyte differentiation" EXACT []
synonym: "down-regulation of myeloid leukocyte differentiation" EXACT []
synonym: "downregulation of myeloid leukocyte differentiation" EXACT []
synonym: "inhibition of myeloid leukocyte differentiation" NARROW []
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
relationship: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0002763
name: positive regulation of myeloid leukocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]
synonym: "activation of myeloid leukocyte differentiation" NARROW []
synonym: "stimulation of myeloid leukocyte differentiation" NARROW []
synonym: "up regulation of myeloid leukocyte differentiation" EXACT []
synonym: "up-regulation of myeloid leukocyte differentiation" EXACT []
synonym: "upregulation of myeloid leukocyte differentiation" EXACT []
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
relationship: positively_regulates GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0002764
name: immune response-regulating signaling pathway
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571]
is_a: GO:0023033 ! signaling pathway
is_a: GO:0050776 ! regulation of immune response

[Term]
id: GO:0002765
name: immune response-inhibiting signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002764 ! immune response-regulating signaling pathway

[Term]
id: GO:0002766
name: innate immune response-inhibiting signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571]
is_a: GO:0002765 ! immune response-inhibiting signal transduction

[Term]
id: GO:0002767
name: immune response-inhibiting cell surface receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571]
synonym: "immune response-inhibiting cell surface receptor signalling pathway" EXACT []
is_a: GO:0002765 ! immune response-inhibiting signal transduction
is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway

[Term]
id: GO:0002768
name: immune response-regulating cell surface receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571]
synonym: "immune response-regulating cell surface receptor signalling pathway" EXACT []
is_a: GO:0002764 ! immune response-regulating signaling pathway
is_a: GO:0007166 ! cell surface receptor linked signaling pathway
is_a: GO:0023034 ! intracellular signaling pathway

[Term]
id: GO:0002769
name: natural killer cell inhibitory signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571]
synonym: "inhibitory KIR signaling pathway" NARROW []
synonym: "killer cell inhibitory receptor signaling pathway" NARROW []
synonym: "Ly49 inhibitory receptor signaling pathway" NARROW []
synonym: "natural killer cell inhibitory signalling pathway" EXACT []
synonym: "NK cell inhibitory signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002770
name: T cell inhibitory signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:15258309]
synonym: "T cell inhibitory signalling pathway" EXACT []
synonym: "T lymphocyte inhibitory signaling pathway" EXACT []
synonym: "T-cell inhibitory signaling pathway" EXACT []
synonym: "T-lymphocyte inhibitory signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002771
name: inhibitory killer cell immunoglobulin-like receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571]
synonym: "inhibitory killer cell immunoglobulin-like receptor signalling pathway" EXACT []
synonym: "killer cell inhibitory receptor signaling pathway" EXACT []
synonym: "KIR signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002772
name: inhibitory C-type lectin receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571]
synonym: "inhibitory C-type lectin receptor signalling pathway" EXACT []
synonym: "Ly49 inhibitory receptor signaling pathway" NARROW []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002773
name: B cell inhibitory signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:16413920]
synonym: "B cell inhibitory signalling pathway" EXACT []
synonym: "B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway" EXACT []
synonym: "B-cell inhibitory signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002774
name: Fc receptor mediated inhibitory signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "Fc receptor mediated inhibitory signalling pathway" EXACT []
synonym: "Fc-receptor mediated inhibitory signaling pathway" EXACT []
is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway

[Term]
id: GO:0002775
name: antimicrobial peptide production
namespace: biological_process
def: "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771]
is_a: GO:0002440 ! production of molecular mediator of immune response
relationship: part_of GO:0019730 ! antimicrobial humoral response

[Term]
id: GO:0002776
name: antimicrobial peptide secretion
namespace: biological_process
def: "The regulated release of an antimicrobial peptide from a cell or group of cells. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771]
is_a: GO:0002790 ! peptide secretion
relationship: part_of GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002777
name: antimicrobial peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771]
is_a: GO:0043043 ! peptide biosynthetic process
relationship: part_of GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002778
name: antibacterial peptide production
namespace: biological_process
def: "The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771]
is_a: GO:0002775 ! antimicrobial peptide production
relationship: part_of GO:0019731 ! antibacterial humoral response

[Term]
id: GO:0002779
name: antibacterial peptide secretion
namespace: biological_process
def: "The regulated release of an antibacterial peptide from a cell or group of cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771]
is_a: GO:0002776 ! antimicrobial peptide secretion
relationship: part_of GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002780
name: antibacterial peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771]
is_a: GO:0002777 ! antimicrobial peptide biosynthetic process
relationship: part_of GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002781
name: antifungal peptide production
namespace: biological_process
def: "The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771]
is_a: GO:0002775 ! antimicrobial peptide production
relationship: part_of GO:0019732 ! antifungal humoral response

[Term]
id: GO:0002782
name: antifungal peptide secretion
namespace: biological_process
def: "The regulated release of an antifungal peptide from a cell or group of cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771]
is_a: GO:0002776 ! antimicrobial peptide secretion
relationship: part_of GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002783
name: antifungal peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antifungal peptide." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771]
is_a: GO:0002777 ! antimicrobial peptide biosynthetic process
relationship: part_of GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002784
name: regulation of antimicrobial peptide production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response
is_a: GO:0002759 ! regulation of antimicrobial humoral response
relationship: regulates GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002785
name: negative regulation of antimicrobial peptide production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]
synonym: "down regulation of antimicrobial peptide production" EXACT []
synonym: "down-regulation of antimicrobial peptide production" EXACT []
synonym: "downregulation of antimicrobial peptide production" EXACT []
synonym: "inhibition of antimicrobial peptide production" NARROW []
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:0002784 ! regulation of antimicrobial peptide production
relationship: negatively_regulates GO:0002775 ! antimicrobial peptide production

[Term]
id: GO:0002786
name: regulation of antibacterial peptide production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide production." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:0031347 ! regulation of defense response
relationship: regulates GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002787
name: negative regulation of antibacterial peptide production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production." [GOC:add]
synonym: "down regulation of antibacterial peptide production" EXACT []
synonym: "down-regulation of antibacterial peptide production" EXACT []
synonym: "downregulation of antibacterial peptide production" EXACT []
synonym: "inhibition of antibacterial peptide production" NARROW []
is_a: GO:0002785 ! negative regulation of antimicrobial peptide production
is_a: GO:0002786 ! regulation of antibacterial peptide production
relationship: negatively_regulates GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002788
name: regulation of antifungal peptide production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antifungal peptide production." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:0031347 ! regulation of defense response
relationship: regulates GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002789
name: negative regulation of antifungal peptide production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production." [GOC:add]
synonym: "down regulation of antifungal peptide production" EXACT []
synonym: "down-regulation of antifungal peptide production" EXACT []
synonym: "downregulation of antifungal peptide production" EXACT []
synonym: "inhibition of antifungal peptide production" NARROW []
is_a: GO:0002785 ! negative regulation of antimicrobial peptide production
is_a: GO:0002788 ! regulation of antifungal peptide production
relationship: negatively_regulates GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002790
name: peptide secretion
namespace: biological_process
def: "The controlled release of a peptide from a cell or group of cells." [GOC:add]
is_a: GO:0015833 ! peptide transport
is_a: GO:0046903 ! secretion

[Term]
id: GO:0002791
name: regulation of peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add]
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0090087 ! regulation of peptide transport
relationship: regulates GO:0002790 ! peptide secretion

[Term]
id: GO:0002792
name: negative regulation of peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add]
synonym: "down regulation of peptide secretion" EXACT []
synonym: "down-regulation of peptide secretion" EXACT []
synonym: "downregulation of peptide secretion" EXACT []
synonym: "inhibition of peptide secretion" NARROW []
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0051048 ! negative regulation of secretion
relationship: negatively_regulates GO:0002790 ! peptide secretion

[Term]
id: GO:0002793
name: positive regulation of peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add]
synonym: "activation of peptide secretion" NARROW []
synonym: "stimulation of peptide secretion" NARROW []
synonym: "up regulation of peptide secretion" EXACT []
synonym: "up-regulation of peptide secretion" EXACT []
synonym: "upregulation of peptide secretion" EXACT []
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0051047 ! positive regulation of secretion
relationship: positively_regulates GO:0002790 ! peptide secretion

[Term]
id: GO:0002794
name: regulation of antimicrobial peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:0002791 ! regulation of peptide secretion
relationship: regulates GO:0002776 ! antimicrobial peptide secretion

[Term]
id: GO:0002795
name: negative regulation of antimicrobial peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]
synonym: "down regulation of antimicrobial peptide secretion" EXACT []
synonym: "down-regulation of antimicrobial peptide secretion" EXACT []
synonym: "downregulation of antimicrobial peptide secretion" EXACT []
synonym: "inhibition of antimicrobial peptide secretion" NARROW []
is_a: GO:0002792 ! negative regulation of peptide secretion
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
relationship: negatively_regulates GO:0002776 ! antimicrobial peptide secretion

[Term]
id: GO:0002796
name: positive regulation of antimicrobial peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]
synonym: "activation of antimicrobial peptide secretion" NARROW []
synonym: "stimulation of antimicrobial peptide secretion" NARROW []
synonym: "up regulation of antimicrobial peptide secretion" EXACT []
synonym: "up-regulation of antimicrobial peptide secretion" EXACT []
synonym: "upregulation of antimicrobial peptide secretion" EXACT []
is_a: GO:0002793 ! positive regulation of peptide secretion
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
relationship: positively_regulates GO:0002776 ! antimicrobial peptide secretion

[Term]
id: GO:0002797
name: regulation of antibacterial peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add]
is_a: GO:0002786 ! regulation of antibacterial peptide production
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
relationship: regulates GO:0002779 ! antibacterial peptide secretion

[Term]
id: GO:0002798
name: negative regulation of antibacterial peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add]
synonym: "down regulation of antibacterial peptide secretion" EXACT []
synonym: "down-regulation of antibacterial peptide secretion" EXACT []
synonym: "downregulation of antibacterial peptide secretion" EXACT []
synonym: "inhibition of antibacterial peptide secretion" NARROW []
is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion
is_a: GO:0002797 ! regulation of antibacterial peptide secretion
relationship: negatively_regulates GO:0002779 ! antibacterial peptide secretion

[Term]
id: GO:0002799
name: positive regulation of antibacterial peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add]
synonym: "activation of antibacterial peptide secretion" NARROW []
synonym: "stimulation of antibacterial peptide secretion" NARROW []
synonym: "up regulation of antibacterial peptide secretion" EXACT []
synonym: "up-regulation of antibacterial peptide secretion" EXACT []
synonym: "upregulation of antibacterial peptide secretion" EXACT []
is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion
is_a: GO:0002797 ! regulation of antibacterial peptide secretion
relationship: positively_regulates GO:0002779 ! antibacterial peptide secretion

[Term]
id: GO:0002800
name: regulation of antifungal peptide secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antifungal peptide secretion." [GOC:add]
is_a: GO:0002788 ! regulation of antifungal peptide production
is_a: GO:0002794 ! regulation of antimicrobial peptide secretion
relationship: regulates GO:0002782 ! antifungal peptide secretion

[Term]
id: GO:0002801
name: negative regulation of antifungal peptide secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion." [GOC:add]
synonym: "down regulation of antifungal peptide secretion" EXACT []
synonym: "down-regulation of antifungal peptide secretion" EXACT []
synonym: "downregulation of antifungal peptide secretion" EXACT []
synonym: "inhibition of antifungal peptide secretion" NARROW []
is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion
is_a: GO:0002800 ! regulation of antifungal peptide secretion
relationship: negatively_regulates GO:0002782 ! antifungal peptide secretion

[Term]
id: GO:0002802
name: positive regulation of antifungal peptide secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion." [GOC:add]
synonym: "activation of antifungal peptide secretion" NARROW []
synonym: "stimulation of antifungal peptide secretion" NARROW []
synonym: "up regulation of antifungal peptide secretion" EXACT []
synonym: "up-regulation of antifungal peptide secretion" EXACT []
synonym: "upregulation of antifungal peptide secretion" EXACT []
is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion
is_a: GO:0002800 ! regulation of antifungal peptide secretion
relationship: positively_regulates GO:0002782 ! antifungal peptide secretion

[Term]
id: GO:0002803
name: positive regulation of antibacterial peptide production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production." [GOC:add]
synonym: "activation of antibacterial peptide production" NARROW []
synonym: "stimulation of antibacterial peptide production" NARROW []
synonym: "up regulation of antibacterial peptide production" EXACT []
synonym: "up-regulation of antibacterial peptide production" EXACT []
synonym: "upregulation of antibacterial peptide production" EXACT []
is_a: GO:0002225 ! positive regulation of antimicrobial peptide production
is_a: GO:0002786 ! regulation of antibacterial peptide production
relationship: positively_regulates GO:0002778 ! antibacterial peptide production

[Term]
id: GO:0002804
name: positive regulation of antifungal peptide production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide production." [GOC:add]
synonym: "activation of antifungal peptide production" NARROW []
synonym: "stimulation of antifungal peptide production" NARROW []
synonym: "up regulation of antifungal peptide production" EXACT []
synonym: "up-regulation of antifungal peptide production" EXACT []
synonym: "upregulation of antifungal peptide production" EXACT []
is_a: GO:0002225 ! positive regulation of antimicrobial peptide production
is_a: GO:0002788 ! regulation of antifungal peptide production
relationship: positively_regulates GO:0002781 ! antifungal peptide production

[Term]
id: GO:0002805
name: regulation of antimicrobial peptide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
is_a: GO:0002784 ! regulation of antimicrobial peptide production
is_a: GO:0031326 ! regulation of cellular biosynthetic process
relationship: regulates GO:0002777 ! antimicrobial peptide biosynthetic process

[Term]
id: GO:0002806
name: negative regulation of antimicrobial peptide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
synonym: "down regulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "down-regulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "downregulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "inhibition of antimicrobial peptide biosynthetic process" NARROW []
is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
relationship: negatively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process

[Term]
id: GO:0002807
name: positive regulation of antimicrobial peptide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]
synonym: "activation of antimicrobial peptide biosynthetic process" NARROW []
synonym: "stimulation of antimicrobial peptide biosynthetic process" NARROW []
synonym: "up regulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "up-regulation of antimicrobial peptide biosynthetic process" EXACT []
synonym: "upregulation of antimicrobial peptide biosynthetic process" EXACT []
is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
relationship: positively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process

[Term]
id: GO:0002808
name: regulation of antibacterial peptide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add]
is_a: GO:0002786 ! regulation of antibacterial peptide production
is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process
relationship: regulates GO:0002780 ! antibacterial peptide biosynthetic process

[Term]
id: GO:0002809
name: negative regulation of antibacterial peptide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add]
synonym: "down regulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "down-regulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "downregulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "inhibition of antibacterial peptide biosynthetic process" NARROW []
is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process
is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process
relationship: negatively_regulates GO:0002780 ! antibacterial peptide biosynthetic process

[Term]
id: GO:0002810
name: regulation of antifungal peptide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add]
is_a: GO:0002788 ! regulation of antifungal peptide production
is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process
relationship: regulates GO:0002783 ! antifungal peptide biosynthetic process

[Term]
id: GO:0002811
name: negative regulation of antifungal peptide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add]
synonym: "down regulation of antifungal peptide biosynthetic process" EXACT []
synonym: "down-regulation of antifungal peptide biosynthetic process" EXACT []
synonym: "downregulation of antifungal peptide biosynthetic process" EXACT []
synonym: "inhibition of antifungal peptide biosynthetic process" NARROW []
is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process
is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process
relationship: negatively_regulates GO:0002783 ! antifungal peptide biosynthetic process

[Term]
id: GO:0002812
name: biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria." [GOC:add, PMID:11807545]
is_a: GO:0002780 ! antibacterial peptide biosynthetic process
relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium

[Term]
id: GO:0002813
name: regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add]
is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process
relationship: regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria

[Term]
id: GO:0002814
name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add]
synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW []
is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process
is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
relationship: negatively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria

[Term]
id: GO:0002815
name: biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria." [GOC:add]
is_a: GO:0002780 ! antibacterial peptide biosynthetic process
relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium

[Term]
id: GO:0002816
name: regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add]
is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process
relationship: regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria

[Term]
id: GO:0002817
name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add]
synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW []
is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process
is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
relationship: negatively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria

[Term]
id: GO:0002818
name: intracellular defense response
namespace: biological_process
def: "A physiological defense response which occurs intracellularly." [GOC:add]
synonym: "intracellular defence response" EXACT []
is_a: GO:0006968 ! cellular defense response
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0002819
name: regulation of adaptive immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add]
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002250 ! adaptive immune response

[Term]
id: GO:0002820
name: negative regulation of adaptive immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add]
synonym: "down regulation of adaptive immune response" EXACT []
synonym: "down-regulation of adaptive immune response" EXACT []
synonym: "downregulation of adaptive immune response" EXACT []
synonym: "inhibition of adaptive immune response" NARROW []
is_a: GO:0002819 ! regulation of adaptive immune response
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0002250 ! adaptive immune response

[Term]
id: GO:0002821
name: positive regulation of adaptive immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add]
synonym: "activation of adaptive immune response" NARROW []
synonym: "stimulation of adaptive immune response" NARROW []
synonym: "up regulation of adaptive immune response" EXACT []
synonym: "up-regulation of adaptive immune response" EXACT []
synonym: "upregulation of adaptive immune response" EXACT []
is_a: GO:0002819 ! regulation of adaptive immune response
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0002250 ! adaptive immune response

[Term]
id: GO:0002822
name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002819 ! regulation of adaptive immune response
relationship: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002823
name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002820 ! negative regulation of adaptive immune response
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002824
name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]
is_a: GO:0002821 ! positive regulation of adaptive immune response
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0002825
name: regulation of T-helper 1 type immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add]
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: regulates GO:0042088 ! T-helper 1 type immune response

[Term]
id: GO:0002826
name: negative regulation of T-helper 1 type immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add]
synonym: "down regulation of T-helper 1 type immune response" EXACT []
synonym: "down-regulation of T-helper 1 type immune response" EXACT []
synonym: "downregulation of T-helper 1 type immune response" EXACT []
synonym: "inhibition of T-helper 1 type immune response" NARROW []
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002825 ! regulation of T-helper 1 type immune response
relationship: negatively_regulates GO:0042088 ! T-helper 1 type immune response

[Term]
id: GO:0002827
name: positive regulation of T-helper 1 type immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add]
synonym: "activation of T-helper 1 type immune response" NARROW []
synonym: "stimulation of T-helper 1 type immune response" NARROW []
synonym: "up regulation of T-helper 1 type immune response" EXACT []
synonym: "up-regulation of T-helper 1 type immune response" EXACT []
synonym: "upregulation of T-helper 1 type immune response" EXACT []
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002825 ! regulation of T-helper 1 type immune response
relationship: positively_regulates GO:0042088 ! T-helper 1 type immune response

[Term]
id: GO:0002828
name: regulation of T-helper 2 type immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a T-helper 2 type immune response." [GOC:add]
is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
relationship: regulates GO:0042092 ! T-helper 2 type immune response

[Term]
id: GO:0002829
name: negative regulation of T-helper 2 type immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 2 type immune response." [GOC:add]
synonym: "down regulation of T-helper 2 type immune response" EXACT []
synonym: "down-regulation of T-helper 2 type immune response" EXACT []
synonym: "downregulation of T-helper 2 type immune response" EXACT []
synonym: "inhibition of T-helper 2 type immune response" NARROW []
is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002828 ! regulation of T-helper 2 type immune response
relationship: negatively_regulates GO:0042092 ! T-helper 2 type immune response

[Term]
id: GO:0002830
name: positive regulation of T-helper 2 type immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a T-helper 2 type immune response." [GOC:add]
synonym: "activation of T-helper 2 type immune response" NARROW []
synonym: "stimulation of T-helper 2 type immune response" NARROW []
synonym: "up regulation of T-helper 2 type immune response" EXACT []
synonym: "up-regulation of T-helper 2 type immune response" EXACT []
synonym: "upregulation of T-helper 2 type immune response" EXACT []
is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
is_a: GO:0002828 ! regulation of T-helper 2 type immune response
relationship: positively_regulates GO:0042092 ! T-helper 2 type immune response

[Term]
id: GO:0002831
name: regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002832
name: negative regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
synonym: "down regulation of response to biotic stimulus" EXACT []
synonym: "down-regulation of response to biotic stimulus" EXACT []
synonym: "downregulation of response to biotic stimulus" EXACT []
synonym: "inhibition of response to biotic stimulus" NARROW []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002833
name: positive regulation of response to biotic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]
synonym: "activation of response to biotic stimulus" NARROW []
synonym: "stimulation of response to biotic stimulus" NARROW []
synonym: "up regulation of response to biotic stimulus" EXACT []
synonym: "up-regulation of response to biotic stimulus" EXACT []
synonym: "upregulation of response to biotic stimulus" EXACT []
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0002834
name: regulation of response to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a response to tumor cell." [GOC:add]
synonym: "regulation of response to tumour cell" EXACT []
is_a: GO:0002831 ! regulation of response to biotic stimulus
relationship: regulates GO:0002347 ! response to tumor cell

[Term]
id: GO:0002835
name: negative regulation of response to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell." [GOC:add]
synonym: "down regulation of response to tumor cell" EXACT []
synonym: "down-regulation of response to tumor cell" EXACT []
synonym: "downregulation of response to tumor cell" EXACT []
synonym: "inhibition of response to tumor cell" NARROW []
synonym: "negative regulation of response to tumour cell" EXACT []
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0002834 ! regulation of response to tumor cell
relationship: negatively_regulates GO:0002347 ! response to tumor cell

[Term]
id: GO:0002836
name: positive regulation of response to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a response to tumor cell." [GOC:add]
synonym: "activation of response to tumor cell" NARROW []
synonym: "positive regulation of response to tumour cell" EXACT []
synonym: "stimulation of response to tumor cell" NARROW []
synonym: "up regulation of response to tumor cell" EXACT []
synonym: "up-regulation of response to tumor cell" EXACT []
synonym: "upregulation of response to tumor cell" EXACT []
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0002834 ! regulation of response to tumor cell
relationship: positively_regulates GO:0002347 ! response to tumor cell

[Term]
id: GO:0002837
name: regulation of immune response to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immune response to tumor cell." [GOC:add]
synonym: "regulation of immune response to tumour cell" EXACT []
is_a: GO:0002834 ! regulation of response to tumor cell
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002418 ! immune response to tumor cell

[Term]
id: GO:0002838
name: negative regulation of immune response to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell." [GOC:add]
synonym: "down regulation of immune response to tumor cell" EXACT []
synonym: "down-regulation of immune response to tumor cell" EXACT []
synonym: "downregulation of immune response to tumor cell" EXACT []
synonym: "inhibition of immune response to tumor cell" NARROW []
synonym: "negative regulation of immune response to tumour cell" EXACT []
is_a: GO:0002835 ! negative regulation of response to tumor cell
is_a: GO:0002837 ! regulation of immune response to tumor cell
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0002418 ! immune response to tumor cell

[Term]
id: GO:0002839
name: positive regulation of immune response to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell." [GOC:add]
synonym: "activation of immune response to tumor cell" NARROW []
synonym: "positive regulation of immune response to tumour cell" EXACT []
synonym: "stimulation of immune response to tumor cell" NARROW []
synonym: "up regulation of immune response to tumor cell" EXACT []
synonym: "up-regulation of immune response to tumor cell" EXACT []
synonym: "upregulation of immune response to tumor cell" EXACT []
is_a: GO:0002836 ! positive regulation of response to tumor cell
is_a: GO:0002837 ! regulation of immune response to tumor cell
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0002418 ! immune response to tumor cell

[Term]
id: GO:0002840
name: regulation of T cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add]
synonym: "regulation of T cell mediated immune response to tumour cell" EXACT []
synonym: "regulation of T lymphocyte mediated immune response to tumor cell" EXACT []
synonym: "regulation of T-cell mediated immune response to tumor cell" EXACT []
synonym: "regulation of T-lymphocyte mediated immune response to tumor cell" EXACT []
is_a: GO:0002709 ! regulation of T cell mediated immunity
is_a: GO:0002837 ! regulation of immune response to tumor cell
relationship: regulates GO:0002424 ! T cell mediated immune response to tumor cell

[Term]
id: GO:0002841
name: negative regulation of T cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add]
synonym: "down regulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "down-regulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "downregulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "inhibition of T cell mediated immune response to tumor cell" NARROW []
synonym: "negative regulation of T cell mediated immune response to tumour cell" EXACT []
synonym: "negative regulation of T lymphocyte mediated immune response to tumor cell" EXACT []
synonym: "negative regulation of T-cell mediated immune response to tumor cell" EXACT []
synonym: "negative regulation of T-lymphocyte mediated immune response to tumor cell" EXACT []
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002838 ! negative regulation of immune response to tumor cell
is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell
relationship: negatively_regulates GO:0002424 ! T cell mediated immune response to tumor cell

[Term]
id: GO:0002842
name: positive regulation of T cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add]
synonym: "activation of T cell mediated immune response to tumor cell" NARROW []
synonym: "positive regulation of T cell mediated immune response to tumour cell" EXACT []
synonym: "positive regulation of T lymphocyte mediated immune response to tumor cell" EXACT []
synonym: "positive regulation of T-cell mediated immune response to tumor cell" EXACT []
synonym: "positive regulation of T-lymphocyte mediated immune response to tumor cell" EXACT []
synonym: "stimulation of T cell mediated immune response to tumor cell" NARROW []
synonym: "up regulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "up-regulation of T cell mediated immune response to tumor cell" EXACT []
synonym: "upregulation of T cell mediated immune response to tumor cell" EXACT []
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002839 ! positive regulation of immune response to tumor cell
is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell
relationship: positively_regulates GO:0002424 ! T cell mediated immune response to tumor cell

[Term]
id: GO:0002843
name: regulation of tolerance induction to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add]
synonym: "regulation of tolerance induction to tumour cell" EXACT []
is_a: GO:0002658 ! regulation of peripheral tolerance induction
is_a: GO:0002837 ! regulation of immune response to tumor cell
relationship: regulates GO:0002413 ! tolerance induction to tumor cell

[Term]
id: GO:0002844
name: negative regulation of tolerance induction to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add]
synonym: "down regulation of tolerance induction to tumor cell" EXACT []
synonym: "down-regulation of tolerance induction to tumor cell" EXACT []
synonym: "downregulation of tolerance induction to tumor cell" EXACT []
synonym: "inhibition of tolerance induction to tumor cell" NARROW []
synonym: "negative regulation of tolerance induction to tumour cell" EXACT []
is_a: GO:0002659 ! negative regulation of peripheral tolerance induction
is_a: GO:0002838 ! negative regulation of immune response to tumor cell
is_a: GO:0002843 ! regulation of tolerance induction to tumor cell
relationship: negatively_regulates GO:0002413 ! tolerance induction to tumor cell

[Term]
id: GO:0002845
name: positive regulation of tolerance induction to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add]
synonym: "activation of tolerance induction to tumor cell" NARROW []
synonym: "positive regulation of tolerance induction to tumour cell" EXACT []
synonym: "stimulation of tolerance induction to tumor cell" NARROW []
synonym: "up regulation of tolerance induction to tumor cell" EXACT []
synonym: "up-regulation of tolerance induction to tumor cell" EXACT []
synonym: "upregulation of tolerance induction to tumor cell" EXACT []
is_a: GO:0002660 ! positive regulation of peripheral tolerance induction
is_a: GO:0002839 ! positive regulation of immune response to tumor cell
is_a: GO:0002843 ! regulation of tolerance induction to tumor cell
relationship: positively_regulates GO:0002413 ! tolerance induction to tumor cell

[Term]
id: GO:0002846
name: regulation of T cell tolerance induction to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add]
is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell
is_a: GO:0002843 ! regulation of tolerance induction to tumor cell
is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction
relationship: regulates GO:0002411 ! T cell tolerance induction to tumor cell

[Term]
id: GO:0002847
name: negative regulation of T cell tolerance induction to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add]
synonym: "down regulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "down-regulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "downregulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "inhibition of T cell tolerance induction to tumor cell" NARROW []
is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell
is_a: GO:0002844 ! negative regulation of tolerance induction to tumor cell
is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell
is_a: GO:0002850 ! negative regulation of peripheral T cell tolerance induction
relationship: negatively_regulates GO:0002411 ! T cell tolerance induction to tumor cell

[Term]
id: GO:0002848
name: positive regulation of T cell tolerance induction to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add]
synonym: "activation of T cell tolerance induction to tumor cell" NARROW []
synonym: "stimulation of T cell tolerance induction to tumor cell" NARROW []
synonym: "up regulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "up-regulation of T cell tolerance induction to tumor cell" EXACT []
synonym: "upregulation of T cell tolerance induction to tumor cell" EXACT []
is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell
is_a: GO:0002845 ! positive regulation of tolerance induction to tumor cell
is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell
is_a: GO:0002851 ! positive regulation of peripheral T cell tolerance induction
relationship: positively_regulates GO:0002411 ! T cell tolerance induction to tumor cell

[Term]
id: GO:0002849
name: regulation of peripheral T cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add]
is_a: GO:0002658 ! regulation of peripheral tolerance induction
is_a: GO:0002664 ! regulation of T cell tolerance induction
is_a: GO:0002709 ! regulation of T cell mediated immunity
relationship: regulates GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002850
name: negative regulation of peripheral T cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add]
synonym: "down regulation of peripheral T cell tolerance induction" EXACT []
synonym: "down-regulation of peripheral T cell tolerance induction" EXACT []
synonym: "downregulation of peripheral T cell tolerance induction" EXACT []
synonym: "inhibition of peripheral T cell tolerance induction" NARROW []
is_a: GO:0002659 ! negative regulation of peripheral tolerance induction
is_a: GO:0002665 ! negative regulation of T cell tolerance induction
is_a: GO:0002710 ! negative regulation of T cell mediated immunity
is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction
relationship: negatively_regulates GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002851
name: positive regulation of peripheral T cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add]
synonym: "activation of peripheral T cell tolerance induction" NARROW []
synonym: "stimulation of peripheral T cell tolerance induction" NARROW []
synonym: "up regulation of peripheral T cell tolerance induction" EXACT []
synonym: "up-regulation of peripheral T cell tolerance induction" EXACT []
synonym: "upregulation of peripheral T cell tolerance induction" EXACT []
is_a: GO:0002660 ! positive regulation of peripheral tolerance induction
is_a: GO:0002666 ! positive regulation of T cell tolerance induction
is_a: GO:0002711 ! positive regulation of T cell mediated immunity
is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction
relationship: positively_regulates GO:0002458 ! peripheral T cell tolerance induction

[Term]
id: GO:0002852
name: regulation of T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add]
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell
relationship: regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002853
name: negative regulation of T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add]
synonym: "down regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "down-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "downregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "inhibition of T cell mediated cytotoxicity directed against tumor cell target" NARROW []
is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity
is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell
is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target
relationship: negatively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002854
name: positive regulation of T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add]
synonym: "activation of T cell mediated cytotoxicity directed against tumor cell target" NARROW []
synonym: "stimulation of T cell mediated cytotoxicity directed against tumor cell target" NARROW []
synonym: "up regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "up-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "upregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT []
is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity
is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell
is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target
relationship: positively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002855
name: regulation of natural killer cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add]
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
is_a: GO:0002837 ! regulation of immune response to tumor cell
relationship: regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell

[Term]
id: GO:0002856
name: negative regulation of natural killer cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add]
synonym: "down regulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "down-regulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "downregulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "inhibition of natural killer cell mediated immune response to tumor cell" NARROW []
is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity
is_a: GO:0002838 ! negative regulation of immune response to tumor cell
is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell
relationship: negatively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell

[Term]
id: GO:0002857
name: positive regulation of natural killer cell mediated immune response to tumor cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add]
synonym: "activation of natural killer cell mediated immune response to tumor cell" NARROW []
synonym: "stimulation of natural killer cell mediated immune response to tumor cell" NARROW []
synonym: "up regulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "up-regulation of natural killer cell mediated immune response to tumor cell" EXACT []
synonym: "upregulation of natural killer cell mediated immune response to tumor cell" EXACT []
is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity
is_a: GO:0002839 ! positive regulation of immune response to tumor cell
is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell
relationship: positively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell

[Term]
id: GO:0002858
name: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add]
is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell
is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity
relationship: regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002859
name: negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add]
synonym: "down regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "down-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "downregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "inhibition of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW []
is_a: GO:0002856 ! negative regulation of natural killer cell mediated immune response to tumor cell
is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity
relationship: negatively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002860
name: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add]
synonym: "activation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW []
synonym: "stimulation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW []
synonym: "up regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "up-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
synonym: "upregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT []
is_a: GO:0002857 ! positive regulation of natural killer cell mediated immune response to tumor cell
is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity
relationship: positively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target

[Term]
id: GO:0002861
name: regulation of inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add]
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002437 ! inflammatory response to antigenic stimulus

[Term]
id: GO:0002862
name: negative regulation of inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "down regulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "down-regulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "downregulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "inhibition of inflammatory response to antigenic stimulus" NARROW []
is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus

[Term]
id: GO:0002863
name: positive regulation of inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "activation of inflammatory response to antigenic stimulus" NARROW []
synonym: "stimulation of inflammatory response to antigenic stimulus" NARROW []
synonym: "up regulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "up-regulation of inflammatory response to antigenic stimulus" EXACT []
synonym: "upregulation of inflammatory response to antigenic stimulus" EXACT []
is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus

[Term]
id: GO:0002864
name: regulation of acute inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add]
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus
relationship: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus

[Term]
id: GO:0002865
name: negative regulation of acute inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "down regulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "down-regulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "downregulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "inhibition of acute inflammatory response to antigenic stimulus" NARROW []
is_a: GO:0002674 ! negative regulation of acute inflammatory response
is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus
is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus
relationship: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus

[Term]
id: GO:0002866
name: positive regulation of acute inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "activation of acute inflammatory response to antigenic stimulus" NARROW []
synonym: "stimulation of acute inflammatory response to antigenic stimulus" NARROW []
synonym: "up regulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "up-regulation of acute inflammatory response to antigenic stimulus" EXACT []
synonym: "upregulation of acute inflammatory response to antigenic stimulus" EXACT []
is_a: GO:0002675 ! positive regulation of acute inflammatory response
is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus
is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus
relationship: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus

[Term]
id: GO:0002867
name: regulation of B cell deletion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell deletion." [GOC:add]
synonym: "regulation of B lymphocyte deletion" EXACT []
synonym: "regulation of B-cell deletion" EXACT []
synonym: "regulation of B-lymphocyte deletion" EXACT []
is_a: GO:0002661 ! regulation of B cell tolerance induction
is_a: GO:0002902 ! regulation of B cell apoptosis
relationship: regulates GO:0002516 ! B cell deletion

[Term]
id: GO:0002868
name: negative regulation of B cell deletion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion." [GOC:add]
synonym: "down regulation of B cell deletion" EXACT []
synonym: "down-regulation of B cell deletion" EXACT []
synonym: "downregulation of B cell deletion" EXACT []
synonym: "inhibition of B cell deletion" NARROW []
synonym: "negative regulation of B lymphocyte deletion" EXACT []
synonym: "negative regulation of B-cell deletion" EXACT []
synonym: "negative regulation of B-lymphocyte deletion" EXACT []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002867 ! regulation of B cell deletion
is_a: GO:0002903 ! negative regulation of B cell apoptosis
relationship: negatively_regulates GO:0002516 ! B cell deletion

[Term]
id: GO:0002869
name: positive regulation of B cell deletion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell deletion." [GOC:add]
synonym: "activation of B cell deletion" NARROW []
synonym: "positive regulation of B lymphocyte deletion" EXACT []
synonym: "positive regulation of B-cell deletion" EXACT []
synonym: "positive regulation of B-lymphocyte deletion" EXACT []
synonym: "stimulation of B cell deletion" NARROW []
synonym: "up regulation of B cell deletion" EXACT []
synonym: "up-regulation of B cell deletion" EXACT []
synonym: "upregulation of B cell deletion" EXACT []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002867 ! regulation of B cell deletion
is_a: GO:0002904 ! positive regulation of B cell apoptosis
relationship: positively_regulates GO:0002516 ! B cell deletion

[Term]
id: GO:0002870
name: T cell anergy
namespace: biological_process
def: "Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "T lymphocyte anergy" EXACT []
synonym: "T-cell anergy" EXACT []
synonym: "T-lymphocyte anergy" EXACT []
is_a: GO:0002249 ! lymphocyte anergy
is_a: GO:0002517 ! T cell tolerance induction

[Term]
id: GO:0002871
name: regulation of natural killer cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add]
synonym: "regulation of NK cell tolerance induction" EXACT []
is_a: GO:0002643 ! regulation of tolerance induction
relationship: regulates GO:0002519 ! natural killer cell tolerance induction

[Term]
id: GO:0002872
name: negative regulation of natural killer cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add]
synonym: "down regulation of natural killer cell tolerance induction" EXACT []
synonym: "down-regulation of natural killer cell tolerance induction" EXACT []
synonym: "downregulation of natural killer cell tolerance induction" EXACT []
synonym: "inhibition of natural killer cell tolerance induction" NARROW []
synonym: "negative regulation of NK cell tolerance induction" EXACT []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002871 ! regulation of natural killer cell tolerance induction
relationship: negatively_regulates GO:0002519 ! natural killer cell tolerance induction

[Term]
id: GO:0002873
name: positive regulation of natural killer cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add]
synonym: "activation of natural killer cell tolerance induction" NARROW []
synonym: "positive regulation of NK cell tolerance induction" EXACT []
synonym: "stimulation of natural killer cell tolerance induction" NARROW []
synonym: "up regulation of natural killer cell tolerance induction" EXACT []
synonym: "up-regulation of natural killer cell tolerance induction" EXACT []
synonym: "upregulation of natural killer cell tolerance induction" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002871 ! regulation of natural killer cell tolerance induction
relationship: positively_regulates GO:0002519 ! natural killer cell tolerance induction

[Term]
id: GO:0002874
name: regulation of chronic inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add]
is_a: GO:0002676 ! regulation of chronic inflammatory response
is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus
relationship: regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus

[Term]
id: GO:0002875
name: negative regulation of chronic inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "down regulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "down-regulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "downregulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "inhibition of chronic inflammatory response to antigenic stimulus" NARROW []
is_a: GO:0002677 ! negative regulation of chronic inflammatory response
is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus
is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus
relationship: negatively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus

[Term]
id: GO:0002876
name: positive regulation of chronic inflammatory response to antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add]
synonym: "activation of chronic inflammatory response to antigenic stimulus" NARROW []
synonym: "stimulation of chronic inflammatory response to antigenic stimulus" NARROW []
synonym: "up regulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "up-regulation of chronic inflammatory response to antigenic stimulus" EXACT []
synonym: "upregulation of chronic inflammatory response to antigenic stimulus" EXACT []
is_a: GO:0002678 ! positive regulation of chronic inflammatory response
is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus
is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus
relationship: positively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus

[Term]
id: GO:0002877
name: regulation of acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add]
is_a: GO:0002673 ! regulation of acute inflammatory response
relationship: regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002878
name: negative regulation of acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add]
synonym: "down regulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "down-regulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "downregulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "inhibition of acute inflammatory response to non-antigenic stimulus" NARROW []
is_a: GO:0002674 ! negative regulation of acute inflammatory response
is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus
relationship: negatively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002879
name: positive regulation of acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add]
synonym: "activation of acute inflammatory response to non-antigenic stimulus" NARROW []
synonym: "stimulation of acute inflammatory response to non-antigenic stimulus" NARROW []
synonym: "up regulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "up-regulation of acute inflammatory response to non-antigenic stimulus" EXACT []
synonym: "upregulation of acute inflammatory response to non-antigenic stimulus" EXACT []
is_a: GO:0002675 ! positive regulation of acute inflammatory response
is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus
relationship: positively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002880
name: regulation of chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add]
is_a: GO:0002676 ! regulation of chronic inflammatory response
relationship: regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002881
name: negative regulation of chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add]
synonym: "down regulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "down-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "downregulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "inhibition of chronic inflammatory response to non-antigenic stimulus" NARROW []
is_a: GO:0002677 ! negative regulation of chronic inflammatory response
is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus
relationship: negatively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002882
name: positive regulation of chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add]
synonym: "activation of chronic inflammatory response to non-antigenic stimulus" NARROW []
synonym: "stimulation of chronic inflammatory response to non-antigenic stimulus" NARROW []
synonym: "up regulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "up-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
synonym: "upregulation of chronic inflammatory response to non-antigenic stimulus" EXACT []
is_a: GO:0002678 ! positive regulation of chronic inflammatory response
is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus
relationship: positively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus

[Term]
id: GO:0002883
name: regulation of hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of hypersensitivity." [GOC:add]
is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus
relationship: regulates GO:0002524 ! hypersensitivity

[Term]
id: GO:0002884
name: negative regulation of hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity." [GOC:add]
synonym: "down regulation of hypersensitivity" EXACT []
synonym: "down-regulation of hypersensitivity" EXACT []
synonym: "downregulation of hypersensitivity" EXACT []
synonym: "inhibition of hypersensitivity" NARROW []
is_a: GO:0002865 ! negative regulation of acute inflammatory response to antigenic stimulus
is_a: GO:0002883 ! regulation of hypersensitivity
relationship: negatively_regulates GO:0002524 ! hypersensitivity

[Term]
id: GO:0002885
name: positive regulation of hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of hypersensitivity." [GOC:add]
synonym: "activation of hypersensitivity" NARROW []
synonym: "stimulation of hypersensitivity" NARROW []
synonym: "up regulation of hypersensitivity" EXACT []
synonym: "up-regulation of hypersensitivity" EXACT []
synonym: "upregulation of hypersensitivity" EXACT []
is_a: GO:0002866 ! positive regulation of acute inflammatory response to antigenic stimulus
is_a: GO:0002883 ! regulation of hypersensitivity
relationship: positively_regulates GO:0002524 ! hypersensitivity

[Term]
id: GO:0002886
name: regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
is_a: GO:0002703 ! regulation of leukocyte mediated immunity
relationship: regulates GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002887
name: negative regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW []
is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
relationship: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002888
name: positive regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]
synonym: "activation of myeloid leukocyte mediated immunity" NARROW []
synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW []
synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT []
synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT []
is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
relationship: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity

[Term]
id: GO:0002889
name: regulation of immunoglobulin mediated immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]
is_a: GO:0002712 ! regulation of B cell mediated immunity
relationship: regulates GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002890
name: negative regulation of immunoglobulin mediated immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]
synonym: "down regulation of immunoglobulin mediated immune response" EXACT []
synonym: "down-regulation of immunoglobulin mediated immune response" EXACT []
synonym: "downregulation of immunoglobulin mediated immune response" EXACT []
synonym: "inhibition of immunoglobulin mediated immune response" NARROW []
is_a: GO:0002713 ! negative regulation of B cell mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
relationship: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002891
name: positive regulation of immunoglobulin mediated immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]
synonym: "activation of immunoglobulin mediated immune response" NARROW []
synonym: "stimulation of immunoglobulin mediated immune response" NARROW []
synonym: "up regulation of immunoglobulin mediated immune response" EXACT []
synonym: "up-regulation of immunoglobulin mediated immune response" EXACT []
synonym: "upregulation of immunoglobulin mediated immune response" EXACT []
is_a: GO:0002714 ! positive regulation of B cell mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
relationship: positively_regulates GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0002892
name: regulation of type II hypersensitivity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type II hypersensitivity." [GOC:add]
is_a: GO:0002883 ! regulation of hypersensitivity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
relationship: regulates GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0002893
name: negative regulation of type II hypersensitivity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity." [GOC:add]
synonym: "down regulation of type II hypersensitivity" EXACT []
synonym: "down-regulation of type II hypersensitivity" EXACT []
synonym: "downregulation of type II hypersensitivity" EXACT []
synonym: "inhibition of type II hypersensitivity" NARROW []
is_a: GO:0002884 ! negative regulation of hypersensitivity
is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
is_a: GO:0002892 ! regulation of type II hypersensitivity
relationship: negatively_regulates GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0002894
name: positive regulation of type II hypersensitivity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity." [GOC:add]
synonym: "activation of type II hypersensitivity" NARROW []
synonym: "stimulation of type II hypersensitivity" NARROW []
synonym: "up regulation of type II hypersensitivity" EXACT []
synonym: "up-regulation of type II hypersensitivity" EXACT []
synonym: "upregulation of type II hypersensitivity" EXACT []
is_a: GO:0002885 ! positive regulation of hypersensitivity
is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
is_a: GO:0002892 ! regulation of type II hypersensitivity
relationship: positively_regulates GO:0002445 ! type II hypersensitivity

[Term]
id: GO:0002895
name: regulation of central B cell tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of central B cell tolerance induction." [GOC:add]
is_a: GO:0002646 ! regulation of central tolerance induction
is_a: GO:0002661 ! regulation of B cell tolerance induction
relationship: regulates GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002896
name: negative regulation of central B cell tolerance induction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction." [GOC:add]
synonym: "down regulation of central B cell tolerance induction" EXACT []
synonym: "down-regulation of central B cell tolerance induction" EXACT []
synonym: "downregulation of central B cell tolerance induction" EXACT []
synonym: "inhibition of central B cell tolerance induction" NARROW []
is_a: GO:0002647 ! negative regulation of central tolerance induction
is_a: GO:0002662 ! negative regulation of B cell tolerance induction
is_a: GO:0002895 ! regulation of central B cell tolerance induction
relationship: negatively_regulates GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002897
name: positive regulation of central B cell tolerance induction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction." [GOC:add]
synonym: "activation of central B cell tolerance induction" NARROW []
synonym: "stimulation of central B cell tolerance induction" NARROW []
synonym: "up regulation of central B cell tolerance induction" EXACT []
synonym: "up-regulation of central B cell tolerance induction" EXACT []
synonym: "upregulation of central B cell tolerance induction" EXACT []
is_a: GO:0002648 ! positive regulation of central tolerance induction
is_a: GO:0002663 ! positive regulation of B cell tolerance induction
is_a: GO:0002895 ! regulation of central B cell tolerance induction
relationship: positively_regulates GO:0002510 ! central B cell tolerance induction

[Term]
id: GO:0002898
name: regulation of central B cell deletion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of central B cell deletion." [GOC:add]
is_a: GO:0002867 ! regulation of B cell deletion
is_a: GO:0002895 ! regulation of central B cell tolerance induction
is_a: GO:0045577 ! regulation of B cell differentiation
relationship: regulates GO:0002342 ! central B cell deletion

[Term]
id: GO:0002899
name: negative regulation of central B cell deletion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion." [GOC:add]
synonym: "down regulation of central B cell deletion" EXACT []
synonym: "down-regulation of central B cell deletion" EXACT []
synonym: "downregulation of central B cell deletion" EXACT []
synonym: "inhibition of central B cell deletion" NARROW []
is_a: GO:0002868 ! negative regulation of B cell deletion
is_a: GO:0002898 ! regulation of central B cell deletion
relationship: negatively_regulates GO:0002342 ! central B cell deletion

[Term]
id: GO:0002900
name: positive regulation of central B cell deletion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of central B cell deletion." [GOC:add]
synonym: "activation of central B cell deletion" NARROW []
synonym: "stimulation of central B cell deletion" NARROW []
synonym: "up regulation of central B cell deletion" EXACT []
synonym: "up-regulation of central B cell deletion" EXACT []
synonym: "upregulation of central B cell deletion" EXACT []
is_a: GO:0002869 ! positive regulation of B cell deletion
is_a: GO:0002898 ! regulation of central B cell deletion
relationship: positively_regulates GO:0002342 ! central B cell deletion

[Term]
id: GO:0002901
name: mature B cell apoptosis
namespace: biological_process
def: "The process of apoptosis in mature B cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "apoptosis of mature B cells" EXACT []
synonym: "apoptosis of mature B lymphocytes" EXACT []
synonym: "apoptosis of mature B-cells" EXACT []
synonym: "apoptosis of mature B-lymphocytes" EXACT []
synonym: "mature B cell programmed cell death by apoptosis" EXACT []
synonym: "mature B lymphocyte apoptosis" EXACT []
synonym: "mature B lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "mature B-cell apoptosis" EXACT []
synonym: "mature B-cell programmed cell death by apoptosis" EXACT []
synonym: "mature B-lymphocyte apoptosis" EXACT []
synonym: "mature B-lymphocyte programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of mature B cells by apoptosis" EXACT []
synonym: "programmed cell death of mature B lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death of mature B-cells by apoptosis" EXACT []
synonym: "programmed cell death of mature B-lymphocytes by apoptosis" EXACT []
synonym: "programmed cell death, mature B cells" EXACT []
synonym: "programmed cell death, mature B lymphocytes" EXACT []
synonym: "programmed cell death, mature B-cells" EXACT []
synonym: "programmed cell death, mature B-lymphocytes" EXACT []
is_a: GO:0001783 ! B cell apoptosis
relationship: part_of GO:0001782 ! B cell homeostasis

[Term]
id: GO:0002902
name: regulation of B cell apoptosis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell apoptosis." [GOC:add]
is_a: GO:0070228 ! regulation of lymphocyte apoptosis
relationship: regulates GO:0001783 ! B cell apoptosis

[Term]
id: GO:0002903
name: negative regulation of B cell apoptosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptosis." [GOC:add]
synonym: "down regulation of B cell apoptosis" EXACT []
synonym: "down-regulation of B cell apoptosis" EXACT []
synonym: "downregulation of B cell apoptosis" EXACT []
synonym: "inhibition of B cell apoptosis" NARROW []
is_a: GO:0002902 ! regulation of B cell apoptosis
is_a: GO:0070229 ! negative regulation of lymphocyte apoptosis
relationship: negatively_regulates GO:0001783 ! B cell apoptosis

[Term]
id: GO:0002904
name: positive regulation of B cell apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of B cell apoptosis." [GOC:add]
synonym: "activation of B cell apoptosis" NARROW []
synonym: "stimulation of B cell apoptosis" NARROW []
synonym: "up regulation of B cell apoptosis" EXACT []
synonym: "up-regulation of B cell apoptosis" EXACT []
synonym: "upregulation of B cell apoptosis" EXACT []
is_a: GO:0002902 ! regulation of B cell apoptosis
is_a: GO:0070230 ! positive regulation of lymphocyte apoptosis
relationship: positively_regulates GO:0001783 ! B cell apoptosis

[Term]
id: GO:0002905
name: regulation of mature B cell apoptosis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mature B cell apoptosis." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0002902 ! regulation of B cell apoptosis
is_a: GO:0032844 ! regulation of homeostatic process
relationship: regulates GO:0002901 ! mature B cell apoptosis

[Term]
id: GO:0002906
name: negative regulation of mature B cell apoptosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptosis." [GOC:add]
synonym: "down regulation of mature B cell apoptosis" EXACT []
synonym: "down-regulation of mature B cell apoptosis" EXACT []
synonym: "downregulation of mature B cell apoptosis" EXACT []
synonym: "inhibition of mature B cell apoptosis" NARROW []
is_a: GO:0002903 ! negative regulation of B cell apoptosis
is_a: GO:0002905 ! regulation of mature B cell apoptosis
relationship: negatively_regulates GO:0002901 ! mature B cell apoptosis

[Term]
id: GO:0002907
name: positive regulation of mature B cell apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of mature B cell apoptosis." [GOC:add]
synonym: "activation of mature B cell apoptosis" NARROW []
synonym: "stimulation of mature B cell apoptosis" NARROW []
synonym: "up regulation of mature B cell apoptosis" EXACT []
synonym: "up-regulation of mature B cell apoptosis" EXACT []
synonym: "upregulation of mature B cell apoptosis" EXACT []
is_a: GO:0002904 ! positive regulation of B cell apoptosis
is_a: GO:0002905 ! regulation of mature B cell apoptosis
relationship: positively_regulates GO:0002901 ! mature B cell apoptosis

[Term]
id: GO:0002908
name: regulation of peripheral B cell deletion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peripheral B cell deletion." [GOC:add]
is_a: GO:0002658 ! regulation of peripheral tolerance induction
is_a: GO:0002712 ! regulation of B cell mediated immunity
is_a: GO:0002867 ! regulation of B cell deletion
relationship: regulates GO:0002454 ! peripheral B cell deletion

[Term]
id: GO:0002909
name: negative regulation of peripheral B cell deletion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion." [GOC:add]
synonym: "down regulation of peripheral B cell deletion" EXACT []
synonym: "down-regulation of peripheral B cell deletion" EXACT []
synonym: "downregulation of peripheral B cell deletion" EXACT []
synonym: "inhibition of peripheral B cell deletion" NARROW []
is_a: GO:0002868 ! negative regulation of B cell deletion
is_a: GO:0002908 ! regulation of peripheral B cell deletion
relationship: negatively_regulates GO:0002454 ! peripheral B cell deletion

[Term]
id: GO:0002910
name: positive regulation of peripheral B cell deletion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion." [GOC:add]
synonym: "activation of peripheral B cell deletion" NARROW []
synonym: "stimulation of peripheral B cell deletion" NARROW []
synonym: "up regulation of peripheral B cell deletion" EXACT []
synonym: "up-regulation of peripheral B cell deletion" EXACT []
synonym: "upregulation of peripheral B cell deletion" EXACT []
is_a: GO:0002869 ! positive regulation of B cell deletion
is_a: GO:0002908 ! regulation of peripheral B cell deletion
relationship: positively_regulates GO:0002454 ! peripheral B cell deletion

[Term]
id: GO:0002911
name: regulation of lymphocyte anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of lymphocyte anergy." [GOC:add]
is_a: GO:0002643 ! regulation of tolerance induction
relationship: regulates GO:0002249 ! lymphocyte anergy

[Term]
id: GO:0002912
name: negative regulation of lymphocyte anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy." [GOC:add]
synonym: "down regulation of lymphocyte anergy" EXACT []
synonym: "down-regulation of lymphocyte anergy" EXACT []
synonym: "downregulation of lymphocyte anergy" EXACT []
synonym: "inhibition of lymphocyte anergy" NARROW []
is_a: GO:0002644 ! negative regulation of tolerance induction
is_a: GO:0002911 ! regulation of lymphocyte anergy
relationship: negatively_regulates GO:0002249 ! lymphocyte anergy

[Term]
id: GO:0002913
name: positive regulation of lymphocyte anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy." [GOC:add]
synonym: "activation of lymphocyte anergy" NARROW []
synonym: "stimulation of lymphocyte anergy" NARROW []
synonym: "up regulation of lymphocyte anergy" EXACT []
synonym: "up-regulation of lymphocyte anergy" EXACT []
synonym: "upregulation of lymphocyte anergy" EXACT []
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0002911 ! regulation of lymphocyte anergy
relationship: positively_regulates GO:0002249 ! lymphocyte anergy

[Term]
id: GO:0002914
name: regulation of central B cell anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of central B cell anergy." [GOC:add]
is_a: GO:0002670 ! regulation of B cell anergy
is_a: GO:0002895 ! regulation of central B cell tolerance induction
is_a: GO:0045577 ! regulation of B cell differentiation
relationship: regulates GO:0002341 ! central B cell anergy

[Term]
id: GO:0002915
name: negative regulation of central B cell anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy." [GOC:add]
synonym: "down regulation of central B cell anergy" EXACT []
synonym: "down-regulation of central B cell anergy" EXACT []
synonym: "downregulation of central B cell anergy" EXACT []
synonym: "inhibition of central B cell anergy" NARROW []
is_a: GO:0002671 ! negative regulation of B cell anergy
is_a: GO:0002914 ! regulation of central B cell anergy
relationship: negatively_regulates GO:0002341 ! central B cell anergy

[Term]
id: GO:0002916
name: positive regulation of central B cell anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of central B cell anergy." [GOC:add]
synonym: "activation of central B cell anergy" NARROW []
synonym: "stimulation of central B cell anergy" NARROW []
synonym: "up regulation of central B cell anergy" EXACT []
synonym: "up-regulation of central B cell anergy" EXACT []
synonym: "upregulation of central B cell anergy" EXACT []
is_a: GO:0002672 ! positive regulation of B cell anergy
is_a: GO:0002914 ! regulation of central B cell anergy
relationship: positively_regulates GO:0002341 ! central B cell anergy

[Term]
id: GO:0002917
name: regulation of peripheral B cell anergy
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of peripheral B cell anergy." [GOC:add]
is_a: GO:0002658 ! regulation of peripheral tolerance induction
is_a: GO:0002670 ! regulation of B cell anergy
is_a: GO:0002712 ! regulation of B cell mediated immunity
relationship: regulates GO:0002453 ! peripheral B cell anergy

[Term]
id: GO:0002918
name: negative regulation of peripheral B cell anergy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy." [GOC:add]
synonym: "down regulation of peripheral B cell anergy" EXACT []
synonym: "down-regulation of peripheral B cell anergy" EXACT []
synonym: "downregulation of peripheral B cell anergy" EXACT []
synonym: "inhibition of peripheral B cell anergy" NARROW []
is_a: GO:0002671 ! negative regulation of B cell anergy
is_a: GO:0002917 ! regulation of peripheral B cell anergy
relationship: negatively_regulates GO:0002453 ! peripheral B cell anergy

[Term]
id: GO:0002919
name: positive regulation of peripheral B cell anergy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy." [GOC:add]
synonym: "activation of peripheral B cell anergy" NARROW []
synonym: "stimulation of peripheral B cell anergy" NARROW []
synonym: "up regulation of peripheral B cell anergy" EXACT []
synonym: "up-regulation of peripheral B cell anergy" EXACT []
synonym: "upregulation of peripheral B cell anergy" EXACT []
is_a: GO:0002672 ! positive regulation of B cell anergy
is_a: GO:0002917 ! regulation of peripheral B cell anergy
relationship: positively_regulates GO:0002453 ! peripheral B cell anergy

[Term]
id: GO:0002920
name: regulation of humoral immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add]
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0006959 ! humoral immune response

[Term]
id: GO:0002921
name: negative regulation of humoral immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response." [GOC:add]
synonym: "down regulation of humoral immune response" EXACT []
synonym: "down-regulation of humoral immune response" EXACT []
synonym: "downregulation of humoral immune response" EXACT []
synonym: "inhibition of humoral immune response" NARROW []
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0006959 ! humoral immune response

[Term]
id: GO:0002922
name: positive regulation of humoral immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response." [GOC:add]
synonym: "activation of humoral immune response" NARROW []
synonym: "stimulation of humoral immune response" NARROW []
synonym: "up regulation of humoral immune response" EXACT []
synonym: "up-regulation of humoral immune response" EXACT []
synonym: "upregulation of humoral immune response" EXACT []
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0006959 ! humoral immune response

[Term]
id: GO:0002923
name: regulation of humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add]
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
is_a: GO:0002920 ! regulation of humoral immune response
relationship: regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin

[Term]
id: GO:0002924
name: negative regulation of humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add]
synonym: "down regulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "down-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "downregulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "inhibition of humoral immune response mediated by circulating immunoglobulin" NARROW []
is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response
is_a: GO:0002921 ! negative regulation of humoral immune response
is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin
relationship: negatively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin

[Term]
id: GO:0002925
name: positive regulation of humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add]
synonym: "activation of humoral immune response mediated by circulating immunoglobulin" NARROW []
synonym: "stimulation of humoral immune response mediated by circulating immunoglobulin" NARROW []
synonym: "up regulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "up-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
synonym: "upregulation of humoral immune response mediated by circulating immunoglobulin" EXACT []
is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response
is_a: GO:0002922 ! positive regulation of humoral immune response
is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin
relationship: positively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin

[Term]
id: GO:0003001
name: generation of a signal involved in cell-cell signaling
namespace: biological_process
def: "The cellular process by which a physical entity or change in state, a signal, is created that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal." [GOC:dph]
synonym: "formation of a signal" RELATED []
synonym: "generation of a signal involved in cell-cell signalling" EXACT []
synonym: "signal generation" EXACT []
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0007267 ! cell-cell signaling

[Term]
id: GO:0003002
name: regionalization
namespace: biological_process
def: "The pattern specification process by which an axis or axes is subdivided in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete]
synonym: "pattern formation" RELATED [GOC:dph]
is_a: GO:0007389 ! pattern specification process

[Term]
id: GO:0003003
name: follicular fluid formation in ovarian follicle antrum during fused antrum stage
namespace: biological_process
def: "The menstrual cycle process by which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed during the fused antrum stage of oogenesis." [GOC:dph, GOC:isa_complete]
is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
relationship: part_of GO:0048165 ! fused antrum stage, oogenesis

[Term]
id: GO:0003004
name: follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage
namespace: biological_process
def: "The menstrual cycle process by which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed during the antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete]
is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
relationship: part_of GO:0048164 ! distinct antral spaces stage, oogenesis

[Term]
id: GO:0003005
name: follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage
namespace: biological_process
def: "The menstrual cycle process by which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed during the scattered antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete]
is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum
relationship: part_of GO:0048163 ! scattered antral spaces stage, oogenesis

[Term]
id: GO:0003006
name: reproductive developmental process
namespace: biological_process
def: "A developmental process by which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete]
is_a: GO:0022414 ! reproductive process
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0003007
name: heart morphogenesis
namespace: biological_process
def: "The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]
synonym: "cardiac morphogenesis" RELATED []
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0003008
name: system process
namespace: biological_process
def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio]
synonym: "organ system process" EXACT []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0003009
name: skeletal muscle contraction
namespace: biological_process
def: "A process whereby force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle]
is_a: GO:0006941 ! striated muscle contraction
relationship: part_of GO:0050881 ! musculoskeletal movement

[Term]
id: GO:0003010
name: voluntary skeletal muscle contraction
namespace: biological_process
def: "A process whereby force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle]
is_a: GO:0003009 ! skeletal muscle contraction

[Term]
id: GO:0003011
name: involuntary skeletal muscle contraction
namespace: biological_process
def: "A process whereby force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle]
is_a: GO:0003009 ! skeletal muscle contraction

[Term]
id: GO:0003012
name: muscle system process
namespace: biological_process
def: "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio]
synonym: "muscle physiological process" RELATED []
is_a: GO:0003008 ! system process

[Term]
id: GO:0003013
name: circulatory system process
namespace: biological_process
def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio]
xref: Wikipedia:Circulatory_system
is_a: GO:0003008 ! system process

[Term]
id: GO:0003014
name: renal system process
namespace: biological_process
def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system is responsible for fluid volume regulation and detoxification in an organism." [GOC:mtg_cardio]
synonym: "kidney system process" RELATED []
is_a: GO:0003008 ! system process

[Term]
id: GO:0003015
name: heart process
namespace: biological_process
def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio]
synonym: "cardiac process" RELATED []
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0003016
name: respiratory system process
namespace: biological_process
alt_id: GO:0010802
def: "A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "respiratory gaseous exchange by respiratory system" EXACT []
is_a: GO:0003008 ! system process
is_a: GO:0007585 ! respiratory gaseous exchange

[Term]
id: GO:0003017
name: lymph circulation
namespace: biological_process
def: "The flow of lymph through the body of an animal." [GOC:mtg_cardio]
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0003018
name: vascular process in circulatory system
namespace: biological_process
def: "A circulatory process that occurs at the level of the vasculature." [GOC:mtg_cardio]
synonym: "vasculature process" EXACT []
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0003019
name: central nervous system control of baroreceptor feedback
namespace: biological_process
def: "The neurological process by which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology"]
is_a: GO:0050877 ! neurological system process
relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback

[Term]
id: GO:0003020
name: detection of reduced oxygen by chemoreceptor signaling
namespace: biological_process
def: "The process by which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology"]
synonym: "detection of reduced oxygen by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0070483 ! detection of hypoxia
relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling

[Term]
id: GO:0003021
name: detection of increased carbon dioxide by chemoreceptor signaling
namespace: biological_process
def: "The process by which information about the levels of carbon dioxideare received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology"]
synonym: "detection of increased carbon dioxide by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003031 ! detection of carbon dioxide
relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling

[Term]
id: GO:0003022
name: detection of pH by chemoreceptor signaling
namespace: biological_process
def: "The process by which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology"]
synonym: "detection of pH by chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003030 ! detection of hydrogen ion
relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling

[Term]
id: GO:0003023
name: baroreceptor detection of increased arterial stretch
namespace: biological_process
def: "The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio]
is_a: GO:0001981 ! baroreceptor detection of arterial stretch
relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure

[Term]
id: GO:0003024
name: baroreceptor detection of decreased arterial stretch
namespace: biological_process
def: "The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio]
is_a: GO:0001981 ! baroreceptor detection of arterial stretch
relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure

[Term]
id: GO:0003025
name: regulation of systemic arterial blood pressure by baroreceptor feedback
namespace: biological_process
def: "The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0003026
name: regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
namespace: biological_process
def: "The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "aortic arch baroreceptor control of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback

[Term]
id: GO:0003027
name: regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "carotid body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling" EXACT [GOC:mah]
synonym: "vagal reflex" BROAD []
is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling

[Term]
id: GO:0003028
name: regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "aortic body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of systemic arterial blood pressure by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling

[Term]
id: GO:0003029
name: detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process by which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies." [GOC:mtg_cardio]
synonym: "detection of hypoxic conditions in blood by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling
relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling

[Term]
id: GO:0003030
name: detection of hydrogen ion
namespace: biological_process
def: "The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0003031
name: detection of carbon dioxide
namespace: biological_process
def: "The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0003032
name: detection of oxygen
namespace: biological_process
def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0070482 ! response to oxygen levels

[Term]
id: GO:0003033
name: detection of hypoxic conditions in blood by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process by which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies." [GOC:mtg_cardio]
synonym: "detection of hypoxic conditions in blood by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling
relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling

[Term]
id: GO:0003034
name: detection of increased carbon dioxide by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process by which information about the levels of carbon dioxideare received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio]
synonym: "detection of increased carbon dioxide by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling
relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling

[Term]
id: GO:0003035
name: detection of increased carbon dioxide by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process by which information about the levels of carbon dioxideare received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio]
synonym: "detection of increased carbon dioxide by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling
relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling

[Term]
id: GO:0003036
name: detection of pH by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process by which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio]
synonym: "detection of pH by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003022 ! detection of pH by chemoreceptor signaling
relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling

[Term]
id: GO:0003037
name: detection of pH by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process by which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio]
synonym: "detection of pH by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003022 ! detection of pH by chemoreceptor signaling
relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling

[Term]
id: GO:0003038
name: detection of reduced oxygen by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process by which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio]
synonym: "detection of reduced oxygen by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling
relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling

[Term]
id: GO:0003039
name: detection of reduced oxygen by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process by which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio]
synonym: "detection of reduced oxygen by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling
relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling

[Term]
id: GO:0003040
name: excitation of vasomotor center by aortic body chemoreceptor signaling
namespace: biological_process
def: "The process by which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio]
synonym: "excitation of vasomotor center by aortic body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling
relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling

[Term]
id: GO:0003041
name: excitation of vasomotor center by carotid body chemoreceptor signaling
namespace: biological_process
def: "The process by which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio]
synonym: "excitation of vasomotor center by carotid body chemoreceptor signalling" EXACT [GOC:mah]
is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling
relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling

[Term]
id: GO:0003042
name: vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [ISBN:0323031951 "Principles of Physiology"]
is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling

[Term]
id: GO:0003043
name: vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure
namespace: biological_process
def: "A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:mtg_cardio]
is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure
relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling

[Term]
id: GO:0003044
name: regulation of systemic arterial blood pressure mediated by a chemical signal
namespace: biological_process
def: "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." [GOC:mtg_cardio]
synonym: "blood pressure regulation mediated by a chemical signal" EXACT []
is_a: GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003045
name: regulation of systemic arterial blood pressure by physical factors
namespace: biological_process
def: "The regulation of blood pressure mediated by detection of forces within the circulatory system." [GOC:mtg_cardio]
synonym: "blood pressure regulation by physical factors" EXACT []
is_a: GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003046
name: regulation of systemic arterial blood pressure by stress relaxation
namespace: biological_process
def: "The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "blood pressure regulation by stress relaxation" EXACT []
is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure

[Term]
id: GO:0003047
name: regulation of systemic arterial blood pressure by epinephrine
namespace: biological_process
def: "The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine." [GOC:mtg_cardio]
synonym: "blood pressure regulation by epinephrine" RELATED []
synonym: "regulation of blood pressure by adrenaline" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal
relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine

[Term]
id: GO:0003048
name: regulation of systemic arterial blood pressure by norepinephrine
namespace: biological_process
def: "The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine." [GOC:mtg_cardio]
synonym: "blood pressure regulation by norepinephrine" RELATED []
synonym: "regulation of blood pressure by noradrenaline" EXACT []
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal
relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine

[Term]
id: GO:0003049
name: regulation of systemic arterial blood pressure by capillary fluid shift
namespace: biological_process
def: "The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "blood pressure regulation by capillary fluid shift" EXACT []
is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors

[Term]
id: GO:0003050
name: regulation of systemic arterial blood pressure by atrial natriuretic peptide
namespace: biological_process
def: "The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide." [GOC:mtg_cardio]
synonym: "blood pressure regulation by ANP" RELATED [GOC:mtg_cardio]
synonym: "blood pressure regulation by atrial natriuretic peptide" EXACT []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0003051
name: angiotensin-mediated drinking behavior
namespace: biological_process
def: "The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst." [GOC:mtg_cardio]
synonym: "angiotensin mediated drinking behavior" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042756 ! drinking behavior
relationship: part_of GO:0002035 ! brain renin-angiotensin system

[Term]
id: GO:0003052
name: circadian regulation of systemic arterial blood pressure
namespace: biological_process
def: "Any process by which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]
is_a: GO:0003073 ! regulation of systemic arterial blood pressure
is_a: GO:0007623 ! circadian rhythm

[Term]
id: GO:0003053
name: circadian regulation of heart rate
namespace: biological_process
def: "Any process by which an organism modulates its heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]
synonym: "circadian regulation of heart contraction rate" RELATED []
is_a: GO:0002027 ! regulation of heart rate
is_a: GO:0007623 ! circadian rhythm

[Term]
id: GO:0003054
name: circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus
namespace: biological_process
def: "The process by which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]
synonym: "master pacemaker clock regulation of blood pressure" EXACT []
synonym: "SCN regulation of blood pressure" EXACT []
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
is_a: GO:0003052 ! circadian regulation of systemic arterial blood pressure

[Term]
id: GO:0003055
name: circadian regulation of heart rate by the suprachiasmatic nucleus
namespace: biological_process
def: "The process by which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]
synonym: "circadian regulation of heart contraction rate by the suprachiasmatic nucleus" RELATED []
synonym: "master pacemaker clock regulation of heart rate" EXACT []
synonym: "SCN regulation of heart rate" EXACT []
is_a: GO:0003053 ! circadian regulation of heart rate

[Term]
id: GO:0003056
name: regulation of vascular smooth muscle contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of vascular smooth muscle contraction." [GOC:mtg_cardio, GOC:mtg_sensu, GOC:rl]
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0019229 ! regulation of vasoconstriction
relationship: regulates GO:0014829 ! vascular smooth muscle contraction

[Term]
id: GO:0003057
name: regulation of the force of heart contraction by chemical signal
namespace: biological_process
def: "The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio, GOC:rl]
synonym: "chemical cardiac inotropy" EXACT []
synonym: "regulation of the force of heart muscle contraction by chemical signal" RELATED []
is_a: GO:0002026 ! regulation of the force of heart contraction

[Term]
id: GO:0003058
name: hormonal regulation of the force of heart contraction
namespace: biological_process
def: "The process by which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl]
synonym: "hormonal cardiac inotropy" EXACT []
synonym: "hormonal regulation of the force of heart muscle contraction" RELATED []
is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal

[Term]
id: GO:0003059
name: positive regulation of the force of heart contraction by epinephrine
namespace: biological_process
def: "The process by which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "adrenaline cardiac inotropy" EXACT []
synonym: "adrenaline regulation of the strength of heart muscle contraction" EXACT []
synonym: "epinephrine cardiac inotropy" EXACT []
synonym: "increased force of heart contraction by epinephrine" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of heart contraction by adrenaline" RELATED []
synonym: "positive regulation of heart contraction by epinephrine" RELATED []
is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal
relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine

[Term]
id: GO:0003060
name: negative regulation of the force of heart contraction by acetylcholine
namespace: biological_process
def: "The process by which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "decreased force of heart contraction by acetylcholine" EXACT []
is_a: GO:0003108 ! negative regulation of the force of heart contraction by chemical signal
relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine

[Term]
id: GO:0003061
name: positive regulation of the force of heart contraction by norepinephrine
namespace: biological_process
def: "The process by which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction." [GOC:mtg_cardio, GOC:rl]
synonym: "increased force of heart contraction by adrenaline" RELATED []
synonym: "increased force of heart contraction by norepinephrine" EXACT []
synonym: "noradrenaline cardiac inotropy" EXACT []
synonym: "noradrenaline regulation of the strength of heart muscle contraction" EXACT []
synonym: "norepinephrine cardiac inotropy" EXACT []
synonym: "positive regulation of heart contraction by adrenaline" RELATED []
synonym: "positive regulation of heart contraction by norepinephrine" RELATED []
is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal
relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine

[Term]
id: GO:0003062
name: regulation of heart rate by chemical signal
namespace: biological_process
def: "The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:dph, GOC:mtg_cardio, GOC:rl, GOC:tb]
synonym: "chemical cardiac chronotropy" EXACT []
synonym: "chemical signal regulation of heart contraction rate" RELATED []
synonym: "chemical signal regulation of heart rate" EXACT [GOC:dph, GOC:tb]
is_a: GO:0002027 ! regulation of heart rate

[Term]
id: GO:0003063
name: negative regulation of heart rate by acetylcholine
namespace: biological_process
def: "The process by which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "negative regulation of heart contraction rate by acetylcholine" RELATED []
is_a: GO:0003062 ! regulation of heart rate by chemical signal
is_a: GO:0010459 ! negative regulation of heart rate
relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine

[Term]
id: GO:0003064
name: regulation of the rate of heart contraction by hormone
namespace: biological_process
def: "The process by which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl]
synonym: "hormonal cardiac chronotropy" EXACT []
is_a: GO:0003062 ! regulation of heart rate by chemical signal

[Term]
id: GO:0003065
name: positive regulation of heart rate by epinephrine
namespace: biological_process
def: "The process by which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "adrenaline cardiac chronotropy" EXACT []
synonym: "adrenaline regulation of the rate of heart muscle contraction" EXACT []
synonym: "epinephrine cardiac chronotropy" EXACT []
synonym: "positive regulation of heart contraction rate by epinephrine" RELATED []
synonym: "positive regulation of heart rate by adrenaline" RELATED []
is_a: GO:0003062 ! regulation of heart rate by chemical signal
is_a: GO:0010460 ! positive regulation of heart rate
relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine

[Term]
id: GO:0003066
name: positive regulation of heart rate by norepinephrine
namespace: biological_process
def: "The process by which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]
synonym: "noradrenaline cardiac chronotropy" EXACT []
synonym: "noradrenaline regulation of the rate of heart muscle contraction" EXACT []
synonym: "norepinephrine cardiac chronotropy" EXACT []
synonym: "positive regulation of heart contraction rate by norepinephrine" RELATED []
synonym: "positive regulation of heart rate by adrenaline" EXACT []
is_a: GO:0003062 ! regulation of heart rate by chemical signal
is_a: GO:0010460 ! positive regulation of heart rate
relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine

[Term]
id: GO:0003067
name: circadian regulation of systemic arterial blood pressure by hormone
namespace: biological_process
def: "The process by which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio]
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone
relationship: part_of GO:0003052 ! circadian regulation of systemic arterial blood pressure

[Term]
id: GO:0003068
name: regulation of systemic arterial blood pressure by acetylcholine
namespace: biological_process
def: "The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter." [GOC:mtg_cardio, GOC:rl]
synonym: "blood pressure regulation by acetylcholine" EXACT []
is_a: GO:0003070 ! regulation of systemic arterial blood pressure by neurotransmitter

[Term]
id: GO:0003069
name: vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process by which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure." [GOC:mtg_cardio, GOC:rl]
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure
is_a: GO:0042311 ! vasodilation
relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine

[Term]
id: GO:0003070
name: regulation of systemic arterial blood pressure by neurotransmitter
namespace: biological_process
def: "The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:mtg_cardio, http://cancerweb.ncl.ac.uk]
is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure
is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal

[Term]
id: GO:0003071
name: renal system process involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "renal control of blood pressure" EXACT []
synonym: "renal regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003014 ! renal system process
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003072
name: renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature." [GOC:mtg_cardio]
synonym: "regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb]
synonym: "renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0003073
name: regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio]
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0003074
name: regulation of diuresis
namespace: biological_process
def: "Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0044062 ! regulation of excretion
relationship: regulates GO:0030146 ! diuresis

[Term]
id: GO:0003075
name: renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure
namespace: biological_process
def: "The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system." [GOC:mtg_cardio]
synonym: "renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure

[Term]
id: GO:0003077
name: negative regulation of diuresis
namespace: biological_process
def: "Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio]
is_a: GO:0003074 ! regulation of diuresis
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0030146 ! diuresis

[Term]
id: GO:0003078
name: regulation of natriuresis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0044062 ! regulation of excretion
relationship: regulates GO:0030147 ! natriuresis

[Term]
id: GO:0003079
name: positive regulation of natriuresis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natriuresis." [GOC:mtg_cardio]
is_a: GO:0003078 ! regulation of natriuresis
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0030147 ! natriuresis

[Term]
id: GO:0003080
name: negative regulation of natriuresis
namespace: biological_process
def: "Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah]
is_a: GO:0003078 ! regulation of natriuresis
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0030147 ! natriuresis

[Term]
id: GO:0003081
name: regulation of systemic arterial blood pressure by renin-angiotensin
namespace: biological_process
def: "The process by which renin-angiotensin modulates the force with which blood passes through the circulatory system." [GOC:mtg_cardio]
synonym: "blood pressure regulation by renin-angiotensin" EXACT []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0003082
name: positive regulation of renal output by angiotensin
namespace: biological_process
def: "Any process by which angiotensin directly increases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "angiotensin mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb]
synonym: "angiotensin-mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb]
is_a: GO:0002019 ! regulation of renal output by angiotensin
is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure

[Term]
id: GO:0003083
name: negative regulation of renal output by angiotensin
namespace: biological_process
def: "The process by which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "angiotensin mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb]
synonym: "angiotensin-mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb]
is_a: GO:0002019 ! regulation of renal output by angiotensin
is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure

[Term]
id: GO:0003084
name: positive regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that increases the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio]
is_a: GO:0045777 ! positive regulation of blood pressure
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003085
name: negative regulation of systemic arterial blood pressure
namespace: biological_process
def: "The process that reduces the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio]
is_a: GO:0045776 ! negative regulation of blood pressure
relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure

[Term]
id: GO:0003086
name: regulation of systemic arterial blood pressure by local renal renin-angiotensin
namespace: biological_process
def: "The process by which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen." [GOC:mtg_cardio]
is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin

[Term]
id: GO:0003087
name: positive regulation of the force of heart contraction by neuronal epinephrine
namespace: biological_process
def: "The process by which the release of epinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by epinephrine released from the nerve endings" EXACT []
synonym: "increased force of heart contraction by neuronal adrenaline" RELATED []
synonym: "increased force of heart contraction by neuronal epinephrine" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of heart contraction by adrenaline" RELATED []
synonym: "positive regulation of heart contraction by neuronal epinephrine" RELATED []
is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine
relationship: part_of GO:0003090 ! positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine

[Term]
id: GO:0003088
name: positive regulation of the force of heart contraction by circulating epinephrine
namespace: biological_process
def: "The process by which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by circulating adrenaline" RELATED []
synonym: "increased force of heart contraction by epinephrine in the bloodstream" EXACT []
synonym: "positive regulation of heart contraction by circulating adrenaline" RELATED []
synonym: "positive regulation of heart contraction by circulating epinephrine" RELATED []
is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine
relationship: part_of GO:0003089 ! positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine

[Term]
id: GO:0003089
name: positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine
namespace: biological_process
def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by circulating adrenaline-noradrenaline" EXACT []
synonym: "increased force of heart contraction by circulating epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb]
synonym: "increased force of heart contraction by epinephrine-norepinephrine in the blood stream" EXACT []
synonym: "positive regulation of heart contraction by circulating adrenaline-noradrenaline" RELATED []
synonym: "positive regulation of heart contraction by circulating epinephrine-norepinephrine" RELATED []
is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine

[Term]
id: GO:0003090
name: positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine
namespace: biological_process
def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings" EXACT []
synonym: "increased force of heart contraction by neuronal adrenaline-noradrenaline" EXACT []
synonym: "increased force of heart contraction by neuronal epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED []
synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED []
is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine

[Term]
id: GO:0003091
name: renal water homeostasis
namespace: biological_process
def: "Renal process involved in the maintenance of internal equilibrium of water in the body." [GOC:mtg_cardio]
is_a: GO:0003014 ! renal system process
is_a: GO:0050891 ! multicellular organismal water homeostasis

[Term]
id: GO:0003092
name: renal water retention
namespace: biological_process
def: "The process whereby renal water excretion is decreased." [GOC:mtg_cardio]
synonym: "negative regulation of renal water excretion" EXACT []
is_a: GO:0003077 ! negative regulation of diuresis

[Term]
id: GO:0003093
name: regulation of glomerular filtration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]
is_a: GO:0001977 ! renal system process involved in regulation of blood volume
is_a: GO:0044057 ! regulation of system process
relationship: regulates GO:0003094 ! glomerular filtration

[Term]
id: GO:0003094
name: glomerular filtration
namespace: biological_process
def: "The process whereby plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"]
is_a: GO:0003014 ! renal system process

[Term]
id: GO:0003095
name: pressure natriuresis
namespace: biological_process
def: "The process by which the volume of blood increases renal pressure and results in an increase in natriuresis and diuresis." [GOC:mtg_cardio]
is_a: GO:0001977 ! renal system process involved in regulation of blood volume

[Term]
id: GO:0003096
name: renal sodium ion transport
namespace: biological_process
def: "The directed movement of sodium ions (Na+) by the kidney." [GOC:mtg_cardio]
is_a: GO:0003014 ! renal system process
is_a: GO:0006814 ! sodium ion transport
relationship: part_of GO:0001977 ! renal system process involved in regulation of blood volume

[Term]
id: GO:0003097
name: renal water transport
namespace: biological_process
def: "The directed movement of water (H2O) by the kidney." [GOC:mtg_cardio]
is_a: GO:0003014 ! renal system process
is_a: GO:0006833 ! water transport
relationship: part_of GO:0001977 ! renal system process involved in regulation of blood volume

[Term]
id: GO:0003098
name: tubuloglomerular feedback
namespace: biological_process
def: "The process by which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus." [GOC:mtg_cardio]
xref: Wikipedia:Tubuloglomerular_feedback
is_a: GO:0001977 ! renal system process involved in regulation of blood volume
relationship: part_of GO:0003093 ! regulation of glomerular filtration

[Term]
id: GO:0003099
name: positive regulation of the force of heart contraction by chemical signal
namespace: biological_process
def: "Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio]
synonym: "positive regulation of the force of heart muscle contraction by chemical signal" EXACT []
is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal
is_a: GO:0045823 ! positive regulation of heart contraction

[Term]
id: GO:0003100
name: regulation of systemic arterial blood pressure by endothelin
namespace: biological_process
def: "The process by which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor." [GOC:mtg_cardio]
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0003101
name: regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine
namespace: biological_process
def: "The process by which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system." [GOC:mtg_cardio]
synonym: "regulation of blood pressure by circulating adrenaline-noradrenaline" RELATED []
is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone

[Term]
id: GO:0003102
name: positive regulation of diuresis by angiotensin
namespace: biological_process
def: "Any process mediated by angiotensin that increases the rate of diuresis." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "angiotensin-mediated positive regulation of diuresis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003082 ! positive regulation of renal output by angiotensin
is_a: GO:0003103 ! positive regulation of diuresis

[Term]
id: GO:0003103
name: positive regulation of diuresis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio]
is_a: GO:0003074 ! regulation of diuresis
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0030146 ! diuresis

[Term]
id: GO:0003104
name: positive regulation of glomerular filtration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]
is_a: GO:0003093 ! regulation of glomerular filtration
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0003094 ! glomerular filtration

[Term]
id: GO:0003105
name: negative regulation of glomerular filtration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]
is_a: GO:0003093 ! regulation of glomerular filtration
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0003094 ! glomerular filtration

[Term]
id: GO:0003106
name: regulation of glomerular filtration by angiotensin
namespace: biological_process
def: "The process by which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:dph, GOC:mah, GOC:tb]
synonym: "angiotensin-mediated regulation of glomerular filtration" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003083 ! negative regulation of renal output by angiotensin
relationship: part_of GO:0003105 ! negative regulation of glomerular filtration

[Term]
id: GO:0003107
name: positive regulation of natriuresis by angiotensin
namespace: biological_process
def: "The process by which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion." [GOC:dph, GOC:mtg_cardio, GOC:tb]
synonym: "angiotensin-mediated positive regulation of natriuresis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003079 ! positive regulation of natriuresis
is_a: GO:0003102 ! positive regulation of diuresis by angiotensin

[Term]
id: GO:0003108
name: negative regulation of the force of heart contraction by chemical signal
namespace: biological_process
def: "Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio]
synonym: "negative regulation of the force of heart muscle contraction by chemical signal" RELATED []
is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal
is_a: GO:0045822 ! negative regulation of heart contraction

[Term]
id: GO:0003109
name: positive regulation of the force of heart contraction by circulating norepinephrine
namespace: biological_process
def: "The process by which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by circulating noradrenaline" RELATED []
synonym: "increased force of heart contraction by circulating norepinephrine" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine

[Term]
id: GO:0003110
name: positive regulation of the force of heart contraction by neuronal norepinephrine
namespace: biological_process
def: "The process by which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio]
synonym: "increased force of heart contraction by neuronal noradrenaline" RELATED []
synonym: "increased force of heart contraction by neuronal norepinephrine" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine

[Term]
id: GO:0003111
name: positive regulation of heart rate by circulating epinephrine
namespace: biological_process
def: "The process by which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio]
synonym: "positive regulation of heart rate by circulating adrenaline" EXACT []
is_a: GO:0003065 ! positive regulation of heart rate by epinephrine

[Term]
id: GO:0003112
name: positive regulation of heart rate by neuronal epinephrine
namespace: biological_process
def: "The process by which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio]
synonym: "positive regulation of heart rate by neuronal adrenaline" EXACT []
is_a: GO:0003065 ! positive regulation of heart rate by epinephrine

[Term]
id: GO:0003113
name: positive regulation of heart rate by neuronal norepinephrine
namespace: biological_process
def: "The process by which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio]
synonym: "positive regulation of heart rate by neuronal noradrenaline" EXACT []
is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine

[Term]
id: GO:0003114
name: positive regulation of heart rate by circulating norepinephrine
namespace: biological_process
def: "The process by which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio]
synonym: "positive regulation of heart rate by circulating noradrenaline" EXACT []
is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine

[Term]
id: GO:0003115
name: regulation of vasoconstriction by epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]
is_a: GO:0019229 ! regulation of vasoconstriction

[Term]
id: GO:0003116
name: regulation of vasoconstriction by norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]
is_a: GO:0019229 ! regulation of vasoconstriction

[Term]
id: GO:0003117
name: regulation of vasoconstriction by circulating norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio]
synonym: "regulation of vasoconstriction by circulating noradrenaline" EXACT []
is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine

[Term]
id: GO:0003118
name: regulation of vasoconstriction by neuronal norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasoconstriction by neuronal noradrenaline" EXACT []
is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine

[Term]
id: GO:0003119
name: regulation of vasoconstriction by neuronal epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasoconstriction by neuronal adrenaline" EXACT []
is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine

[Term]
id: GO:0003120
name: regulation of vasoconstriction by circulating epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio]
synonym: "regulation of vasoconstriction by circulating adrenaline" EXACT []
is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine

[Term]
id: GO:0003121
name: regulation of vasodilation by epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by adrenaline" EXACT []
is_a: GO:0042312 ! regulation of vasodilation

[Term]
id: GO:0003122
name: regulation of vasodilation by norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by noradrenaline" EXACT []
is_a: GO:0042312 ! regulation of vasodilation

[Term]
id: GO:0003123
name: regulation of vasodilation by circulating epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by circulating adrenaline" EXACT []
is_a: GO:0003121 ! regulation of vasodilation by epinephrine

[Term]
id: GO:0003124
name: regulation of vasodilation by neuronal epinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by neuronal adrenaline" EXACT []
is_a: GO:0003121 ! regulation of vasodilation by epinephrine

[Term]
id: GO:0003125
name: regulation of vasodilation by circulating norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by circulating noradrenaline" EXACT []
is_a: GO:0003122 ! regulation of vasodilation by norepinephrine

[Term]
id: GO:0003126
name: regulation of vasodilation by neuronal norepinephrine
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio]
synonym: "regulation of vasodilation by neuronal noradrenaline" EXACT []
is_a: GO:0003122 ! regulation of vasodilation by norepinephrine

[Term]
id: GO:0003127
name: detection of nodal flow
namespace: biological_process
def: "The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry." [GOC:mtg_heart]
is_a: GO:0009726 ! detection of endogenous stimulus
relationship: part_of GO:0007368 ! determination of left/right symmetry

[Term]
id: GO:0003128
name: heart field specification
namespace: biological_process
def: "The process by which a specific region of the lateral mesoderm is delineated into the area in which the heart will develop." [GOC:mtg_heart]
is_a: GO:0010092 ! specification of organ identity
relationship: part_of GO:0060914 ! heart formation

[Term]
id: GO:0003129
name: heart induction
namespace: biological_process
def: "The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart." [GOC:mtg_heart]
is_a: GO:0001759 ! induction of an organ
relationship: positively_regulates GO:0003128 ! heart field specification

[Term]
id: GO:0003130
name: BMP signaling pathway involved in heart induction
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to heart induction." [GOC:mtg_heart]
is_a: GO:0003134 ! endodermal-mesodermal cell signaling involved in heart induction
is_a: GO:0030509 ! BMP signaling pathway

[Term]
id: GO:0003131
name: mesodermal-endodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart]
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0003132
name: mesodermal-endodermal cell signaling involved in heart induction
namespace: biological_process
def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction." [GOC:mtg_heart]
is_a: GO:0003131 ! mesodermal-endodermal cell signaling
is_a: GO:0045168 ! cell-cell signaling involved in cell fate specification
relationship: part_of GO:0003129 ! heart induction

[Term]
id: GO:0003133
name: endodermal-mesodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart]
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0003134
name: endodermal-mesodermal cell signaling involved in heart induction
namespace: biological_process
def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction." [GOC:mtg_heart]
is_a: GO:0003133 ! endodermal-mesodermal cell signaling
is_a: GO:0045168 ! cell-cell signaling involved in cell fate specification
relationship: part_of GO:0003129 ! heart induction

[Term]
id: GO:0003135
name: fibroblast growth factor receptor signaling pathway involved in heart induction
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction." [GOC:mtg_heart]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0003129 ! heart induction

[Term]
id: GO:0003136
name: canonical Wnt receptor signaling pathway involved in heart induction
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes involved in heart induction." [GOC:mtg_heart]
is_a: GO:0003134 ! endodermal-mesodermal cell signaling involved in heart induction
is_a: GO:0003306 ! Wnt receptor signaling pathway involved in heart development
is_a: GO:0060070 ! Wnt receptor signaling pathway through beta-catenin

[Term]
id: GO:0003137
name: Notch signaling pathway involved in heart induction
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:mtg_heart]
is_a: GO:0007219 ! Notch signaling pathway
relationship: part_of GO:0003129 ! heart induction

[Term]
id: GO:0003138
name: primary heart field specification
namespace: biological_process
def: "The process by which a specific region of the lateral mesoderm is delineated into the area which will form the primary beating heart tube." [GOC:mtg_heart]
is_a: GO:0003128 ! heart field specification

[Term]
id: GO:0003139
name: secondary heart field specification
namespace: biological_process
def: "The process by which a specific region of the lateral mesoderm is delineated into the area which will form the majority of the mesodermal component of the right ventricle, arterial and venous poles." [GOC:mtg_heart]
synonym: "anterior heart field specification" NARROW [GOC:mtg_heart]
synonym: "second heart field specification" EXACT [GOC:mtg_heart]
is_a: GO:0003128 ! heart field specification

[Term]
id: GO:0003140
name: determination of left/right asymmetry in lateral mesoderm
namespace: biological_process
def: "The establishment of the lateral mesoderm with respect to the left and right halves." [GOC:mtg_heart]
is_a: GO:0007368 ! determination of left/right symmetry
relationship: part_of GO:0048368 ! lateral mesoderm development

[Term]
id: GO:0003141
name: transforming growth factor beta receptor signaling pathway involved in lateral mesoderm left/right asymmetry determination
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination." [GOC:mtg_heart]
is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway
relationship: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm

[Term]
id: GO:0003142
name: cardiogenic plate morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart]
synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0003143
name: embryonic heart tube morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the embryonic heart tube are generated and organized. Morphogenesis pertains to the creation of form. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0035050 ! embryonic heart tube development

[Term]
id: GO:0003144
name: embryonic heart tube formation
namespace: biological_process
def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis

[Term]
id: GO:0003145
name: embryonic heart tube formation via epithelial folding
namespace: biological_process
def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart]
is_a: GO:0003144 ! embryonic heart tube formation

[Term]
id: GO:0003146
name: heart jogging
namespace: biological_process
def: "The morphogenetic process by which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis." [GOC:mtg_heart, PMID:9334285]
synonym: "cardiac jogging" EXACT [GOC:mtg_heart]
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0003147
name: neural crest cell migration involved in heart formation
namespace: biological_process
def: "The characteristic movement of a cell from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo that contributes to heart formation." [GOC:mtg_heart]
is_a: GO:0001755 ! neural crest cell migration
is_a: GO:0060974 ! cell migration involved in heart formation
relationship: part_of GO:0060914 ! heart formation

[Term]
id: GO:0003148
name: outflow tract septum morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the outflow tract septum are generated and organized. Morphogenesis pertains to the creation of form. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart]
is_a: GO:0060411 ! cardiac septum morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis

[Term]
id: GO:0003149
name: membranous septum morphogenesis
namespace: biological_process
def: "The process by which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum. Morphogenesis pertains to the creation of form." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060412 ! ventricular septum morphogenesis

[Term]
id: GO:0003150
name: muscular septum morphogenesis
namespace: biological_process
def: "The process by which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060412 ! ventricular septum morphogenesis

[Term]
id: GO:0003151
name: outflow tract morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the outflow tract are generated and organized. Morphogenesis pertains to the creation of form. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0003152
name: morphogenesis of an epithelial fold involved in embryonic heart tube formation
namespace: biological_process
def: "The morphogenetic process by which an epithelial sheet bends along a linear axis that contributes to embryonic heart tube formation." [GOC:mtg_heart]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding

[Term]
id: GO:0003153
name: closure of embryonic heart tube
namespace: biological_process
def: "Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold." [GOC:mtg_heart]
is_a: GO:0060606 ! tube closure
relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding

[Term]
id: GO:0003154
name: BMP signaling pathway involved in determination of left/right symmetry
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of left/right symmetry." [GOC:mtg_heart]
is_a: GO:0030509 ! BMP signaling pathway
relationship: part_of GO:0007368 ! determination of left/right symmetry

[Term]
id: GO:0003155
name: BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry." [GOC:mtg_heart]
is_a: GO:0003154 ! BMP signaling pathway involved in determination of left/right symmetry
relationship: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm

[Term]
id: GO:0003156
name: regulation of organ formation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0048645 ! organ formation

[Term]
id: GO:0003157
name: endocardium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an endothelium that is the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0003158 ! endothelium development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0003158
name: endothelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. An endothelium is an epithelium that lines an anatomical structure." [GOC:mtg_heart]
is_a: GO:0060429 ! epithelium development

[Term]
id: GO:0003159
name: morphogenesis of an endothelium
namespace: biological_process
def: "The process by which the anatomical structure of an endothelium is generated and organized. An endothelium is an epithelium that lines an anatomical structure." [GOC:mtg_heart]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0003158 ! endothelium development

[Term]
id: GO:0003160
name: endocardium morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the endocardium is generated and organized. The endocardium is an endothelium that is the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0003159 ! morphogenesis of an endothelium
relationship: part_of GO:0003157 ! endocardium development

[Term]
id: GO:0003161
name: cardiac conduction system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart]
synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart]
synonym: "heart conduction system development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0003162
name: atrioventricular node development
namespace: biological_process
def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart]
synonym: "AV node development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003161 ! cardiac conduction system development

[Term]
id: GO:0003163
name: sinoatrial node development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart]
synonym: "SA node development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003161 ! cardiac conduction system development

[Term]
id: GO:0003164
name: His-Purkinje system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003161 ! cardiac conduction system development

[Term]
id: GO:0003165
name: cardiac Purkinje fiber development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac Purkinje fiber over time, from its formation to the mature structure. The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003164 ! His-Purkinje system development

[Term]
id: GO:0003166
name: bundle of His development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart]
synonym: "atrioventricular bundle development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003164 ! His-Purkinje system development

[Term]
id: GO:0003167
name: atrioventricular bundle cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart]
synonym: "AV bundle cell differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0060932 ! His-Purkinje system cell differentiation
relationship: part_of GO:0003166 ! bundle of His development

[Term]
id: GO:0003168
name: cardiac Purkinje fiber cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac Purkinje fiber cell. These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_heart]
is_a: GO:0060932 ! His-Purkinje system cell differentiation
relationship: part_of GO:0003165 ! cardiac Purkinje fiber development

[Term]
id: GO:0003169
name: coronary vein morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart]
is_a: GO:0048845 ! venous blood vessel morphogenesis
is_a: GO:0060977 ! coronary vasculature morphogenesis

[Term]
id: GO:0003170
name: heart valve development
namespace: biological_process
def: "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart]
synonym: "cardiac valve development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0003171
name: atrioventricular valve development
namespace: biological_process
def: "The progression of the atrioventricular valve over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "AV valve development" EXACT [GOC:mah]
is_a: GO:0003170 ! heart valve development

[Term]
id: GO:0003172
name: sinoatrial valve development
namespace: biological_process
def: "The progression of the sinoatrial valve over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "SA valve development" EXACT [GOC:mah]
is_a: GO:0003170 ! heart valve development

[Term]
id: GO:0003173
name: ventriculo bulbo valve development
namespace: biological_process
def: "The progression of the ventriculo bulbo valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development

[Term]
id: GO:0003174
name: mitral valve development
namespace: biological_process
def: "The progression of the mitral valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development

[Term]
id: GO:0003175
name: tricuspid valve development
namespace: biological_process
def: "The progression of the tricuspid valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development

[Term]
id: GO:0003176
name: aortic valve development
namespace: biological_process
def: "The progression of the aortic valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development

[Term]
id: GO:0003177
name: pulmonary valve development
namespace: biological_process
def: "The progression of the pulmonary valve over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development

[Term]
id: GO:0003178
name: coronary sinus valve development
namespace: biological_process
def: "The progression of the valve of the coronary sinus over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003170 ! heart valve development

[Term]
id: GO:0003179
name: heart valve morphogenesis
namespace: biological_process
def: "The process by which the structure of a heart valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003170 ! heart valve development

[Term]
id: GO:0003180
name: aortic valve morphogenesis
namespace: biological_process
def: "The process by which the structure of the aortic valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003176 ! aortic valve development

[Term]
id: GO:0003181
name: atrioventricular valve morphogenesis
namespace: biological_process
def: "The process by which the structure of the atrioventricular valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart]
synonym: "AV valve morphogenesis" EXACT [GOC:mah]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003171 ! atrioventricular valve development

[Term]
id: GO:0003182
name: coronary sinus valve morphogenesis
namespace: biological_process
def: "The process by which the structure of the coronary sinus valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003178 ! coronary sinus valve development

[Term]
id: GO:0003183
name: mitral valve morphogenesis
namespace: biological_process
def: "The process by which the structure of the mitral valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003174 ! mitral valve development

[Term]
id: GO:0003184
name: pulmonary valve morphogenesis
namespace: biological_process
def: "The process by which the structure of the pulmonary valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003177 ! pulmonary valve development

[Term]
id: GO:0003185
name: sinoatrial valve morphogenesis
namespace: biological_process
def: "The process by which the structure of the sinoatrial valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart]
synonym: "SA valve morphogenesis" EXACT [GOC:mah]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003172 ! sinoatrial valve development

[Term]
id: GO:0003186
name: tricuspid valve morphogenesis
namespace: biological_process
def: "The process by which the structure of the tricuspid valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003175 ! tricuspid valve development

[Term]
id: GO:0003187
name: ventriculo bulbo valve morphogenesis
namespace: biological_process
def: "The process by which the structure of the ventriculo bulbo valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart]
is_a: GO:0003179 ! heart valve morphogenesis
relationship: part_of GO:0003173 ! ventriculo bulbo valve development

[Term]
id: GO:0003188
name: heart valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003179 ! heart valve morphogenesis

[Term]
id: GO:0003189
name: aortic valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003180 ! aortic valve morphogenesis

[Term]
id: GO:0003190
name: atrioventricular valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
synonym: "AV valve formation" EXACT [GOC:mah]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003181 ! atrioventricular valve morphogenesis

[Term]
id: GO:0003191
name: coronary sinus valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003182 ! coronary sinus valve morphogenesis

[Term]
id: GO:0003192
name: mitral valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003183 ! mitral valve morphogenesis

[Term]
id: GO:0003193
name: pulmonary valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003184 ! pulmonary valve morphogenesis

[Term]
id: GO:0003194
name: sinoatrial valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
synonym: "SA valve formation" EXACT [GOC:mah]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003185 ! sinoatrial valve morphogenesis

[Term]
id: GO:0003195
name: tricuspid valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003186 ! tricuspid valve morphogenesis

[Term]
id: GO:0003196
name: ventriculo bulbo valve formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]
is_a: GO:0003188 ! heart valve formation
relationship: part_of GO:0003187 ! ventriculo bulbo valve morphogenesis

[Term]
id: GO:0003197
name: endocardial cushion development
namespace: biological_process
def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0003158 ! endothelium development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0003198
name: epithelial to mesenchymal transition involved in endocardial cushion formation
namespace: biological_process
def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion." [GOC:mtg_heart]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
relationship: part_of GO:0003272 ! endocardial cushion formation

[Term]
id: GO:0003199
name: endocardial cushion to mesenchymal transition involved in valve formation
namespace: biological_process
def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve." [GOC:mtg_heart]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
relationship: part_of GO:0003188 ! heart valve formation

[Term]
id: GO:0003200
name: endocardial cushion to mesenchymal transition involved in heart chamber septation
namespace: biological_process
def: "A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum." [GOC:mtg_heart]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
relationship: part_of GO:0060411 ! cardiac septum morphogenesis

[Term]
id: GO:0003201
name: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis
namespace: biological_process
def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature." [GOC:mtg_heart]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
relationship: part_of GO:0060977 ! coronary vasculature morphogenesis

[Term]
id: GO:0003202
name: endocardial cushion to mesenchymal transition involved in cardiac skeleton development
namespace: biological_process
def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton." [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
relationship: part_of GO:0003204 ! cardiac skeleton development

[Term]
id: GO:0003203
name: endocardial cushion morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0003159 ! morphogenesis of an endothelium
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003197 ! endocardial cushion development

[Term]
id: GO:0003204
name: cardiac skeleton development
namespace: biological_process
def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart]
synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0003205
name: cardiac chamber development
namespace: biological_process
def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
xref: GOC:mtg_heart
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0003206
name: cardiac chamber morphogenesis
namespace: biological_process
def: "The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0003205 ! cardiac chamber development

[Term]
id: GO:0003207
name: cardiac chamber formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]
synonym: "heart chamber formation" EXACT [GOC:mtg_heart]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis

[Term]
id: GO:0003208
name: cardiac ventricle morphogenesis
namespace: biological_process
def: "The process by which the cardiac ventricle is generated and organized." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003231 ! cardiac ventricle development

[Term]
id: GO:0003209
name: cardiac atrium morphogenesis
namespace: biological_process
def: "The process by which the cardiac atrium is generated and organized." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003230 ! cardiac atrium development

[Term]
id: GO:0003210
name: cardiac atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003209 ! cardiac atrium morphogenesis

[Term]
id: GO:0003211
name: cardiac ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis

[Term]
id: GO:0003212
name: cardiac left atrium morphogenesis
namespace: biological_process
def: "The process by which the left cardiac atrium is generated and organized." [GOC:mtg_heart]
is_a: GO:0003209 ! cardiac atrium morphogenesis

[Term]
id: GO:0003213
name: cardiac right atrium morphogenesis
namespace: biological_process
def: "The process by which the right cardiac atrium is generated and organized." [GOC:mtg_heart]
is_a: GO:0003209 ! cardiac atrium morphogenesis

[Term]
id: GO:0003214
name: cardiac left ventricle morphogenesis
namespace: biological_process
def: "The process by which the left cardiac ventricle is generated and organized." [GOC:mtg_heart]
is_a: GO:0003208 ! cardiac ventricle morphogenesis

[Term]
id: GO:0003215
name: cardiac right ventricle morphogenesis
namespace: biological_process
def: "The process by which the right cardiac ventricle is generated and organized." [GOC:mtg_heart]
is_a: GO:0003208 ! cardiac ventricle morphogenesis

[Term]
id: GO:0003216
name: cardiac left atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003210 ! cardiac atrium formation
relationship: part_of GO:0003212 ! cardiac left atrium morphogenesis

[Term]
id: GO:0003217
name: cardiac right atrium formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003210 ! cardiac atrium formation
relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis

[Term]
id: GO:0003218
name: cardiac left ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003211 ! cardiac ventricle formation
relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis

[Term]
id: GO:0003219
name: cardiac right ventricle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart]
is_a: GO:0003211 ! cardiac ventricle formation
relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis

[Term]
id: GO:0003220
name: left ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
synonym: "left ventricular myocardium morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis

[Term]
id: GO:0003221
name: right ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
synonym: "right ventricle myocardium morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis

[Term]
id: GO:0003222
name: ventricular trabecular myocardium morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis

[Term]
id: GO:0003223
name: ventricular compact myocardium morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the compact cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]
is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis

[Term]
id: GO:0003224
name: left ventricular compact myocardium morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003223 ! ventricular compact myocardium morphogenesis

[Term]
id: GO:0003225
name: left ventricular trabecular myocardium morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003222 ! ventricular trabecular myocardium morphogenesis

[Term]
id: GO:0003226
name: right ventricular compact myocardium morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the right ventricular compact myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003223 ! ventricular compact myocardium morphogenesis

[Term]
id: GO:0003227
name: right ventricular trabecular myocardium morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart]
is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis
is_a: GO:0003222 ! ventricular trabecular myocardium morphogenesis

[Term]
id: GO:0003228
name: atrial cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "atrial myocardium development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0003229
name: ventricular cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "ventricular myocardium development" EXACT [GOC:mtg_heart]
is_a: GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0003230
name: cardiac atrium development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development

[Term]
id: GO:0003231
name: cardiac ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development

[Term]
id: GO:0003232
name: bulbus arteriosus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development

[Term]
id: GO:0003233
name: bulbus arteriosus morphogenesis
namespace: biological_process
def: "The process by which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003232 ! bulbus arteriosus development

[Term]
id: GO:0003234
name: bulbus arteriosus formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003233 ! bulbus arteriosus morphogenesis

[Term]
id: GO:0003235
name: sinus venosus development
namespace: biological_process
def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development

[Term]
id: GO:0003236
name: sinus venosus morphogenesis
namespace: biological_process
def: "The process by which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003235 ! sinus venosus development

[Term]
id: GO:0003237
name: sinus venosus formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003236 ! sinus venosus morphogenesis

[Term]
id: GO:0003238
name: conus arteriosus development
namespace: biological_process
def: "The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]
is_a: GO:0003205 ! cardiac chamber development

[Term]
id: GO:0003239
name: conus arteriosus morphogenesis
namespace: biological_process
def: "The process by which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]
is_a: GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003238 ! conus arteriosus development

[Term]
id: GO:0003240
name: conus arteriosus formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]
is_a: GO:0003207 ! cardiac chamber formation
relationship: part_of GO:0003239 ! conus arteriosus morphogenesis

[Term]
id: GO:0003241
name: growth involved in heart morphogenesis
namespace: biological_process
def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0060419 ! heart growth

[Term]
id: GO:0003242
name: cardiac chamber ballooning
namespace: biological_process
def: "The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis

[Term]
id: GO:0003243
name: circumferential growth involved in left ventricle morphogenesis
namespace: biological_process
def: "The morphogenetic growth in which the left ventricle grows expanding its external boundary." [GOC:mtg_heart, PMID:14709543]
is_a: GO:0003241 ! growth involved in heart morphogenesis
relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis

[Term]
id: GO:0003244
name: radial growth involved in right ventricle morphogenesis
namespace: biological_process
def: "The morphogenic growth in which the right ventricle grows along a radial axis." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis

[Term]
id: GO:0003245
name: cardiac muscle tissue growth involved in heart morphogenesis
namespace: biological_process
def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0003241 ! growth involved in heart morphogenesis
is_a: GO:0055017 ! cardiac muscle tissue growth
relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis

[Term]
id: GO:0003246
name: embryonic cardiac muscle cell growth involved in heart morphogenesis
namespace: biological_process
def: "The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart." [GOC:mtg_heart]
synonym: "embryonic cardiac muscle physiological hypertrophy" EXACT [GOC:mtg_heart]
is_a: GO:0061049 ! cell growth involved in cardiac muscle cell development
relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis

[Term]
id: GO:0003247
name: post-embryonic cardiac muscle cell growth involved in heart morphogenesis
namespace: biological_process
def: "The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis

[Term]
id: GO:0003248
name: heart capillary growth
namespace: biological_process
def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart]
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0060419 ! heart growth
relationship: part_of GO:0060976 ! coronary vasculature development

[Term]
id: GO:0003249
name: cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0003179 ! heart valve morphogenesis

[Term]
id: GO:0003250
name: regulation of cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis

[Term]
id: GO:0003251
name: positive regulation of cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis
is_a: GO:0008284 ! positive regulation of cell proliferation
relationship: positively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis

[Term]
id: GO:0003252
name: negative regulation of cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis
is_a: GO:0008285 ! negative regulation of cell proliferation
relationship: negatively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis

[Term]
id: GO:0003253
name: cardiac neural crest cell migration involved in outflow tract morphogenesis
namespace: biological_process
def: "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart]
is_a: GO:0001755 ! neural crest cell migration
is_a: GO:0060973 ! cell migration involved in heart development
relationship: part_of GO:0003151 ! outflow tract morphogenesis

[Term]
id: GO:0003254
name: regulation of membrane depolarization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive." [GOC:dph, GOC:tb]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051899 ! membrane depolarization

[Term]
id: GO:0003255
name: endocardial precursor cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate." [GOC:mtg_heart]
is_a: GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0003256
name: regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation

[Term]
id: GO:0003257
name: positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart]
is_a: GO:0003256 ! regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter

[Term]
id: GO:0003258
name: regulation of transcription from RNA polymerase II promoter involved in endocardial precursor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of an endocardial precursor cell." [GOC:mtg_heart]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0003255 ! endocardial precursor cell differentiation

[Term]
id: GO:0003259
name: cardioblast anterior-lateral migration
namespace: biological_process
def: "The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0003260 ! cardioblast migration

[Term]
id: GO:0003260
name: cardioblast migration
namespace: biological_process
def: "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0060974 ! cell migration involved in heart formation
relationship: part_of GO:0060914 ! heart formation

[Term]
id: GO:0003261
name: cardiac muscle progenitor cell migration to the midline involved in heart field formation
namespace: biological_process
def: "The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart." [GOC:mtg_heart]
synonym: "myocardial progenitor cell midline convergence" EXACT [GOC:mtg_heart]
is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation

[Term]
id: GO:0003262
name: endocardial progenitor cell migration to the midline involved in heart field formation
namespace: biological_process
def: "The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart." [GOC:mtg_heart]
is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation

[Term]
id: GO:0003263
name: cardioblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0008283 ! cell proliferation
is_a: GO:0060914 ! heart formation

[Term]
id: GO:0003264
name: regulation of cardioblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0003156 ! regulation of organ formation
is_a: GO:0042127 ! regulation of cell proliferation
relationship: regulates GO:0003263 ! cardioblast proliferation

[Term]
id: GO:0003265
name: regulation of first heart field cardioblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the first heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0003264 ! regulation of cardioblast proliferation

[Term]
id: GO:0003266
name: regulation of second heart field cardioblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0003264 ! regulation of cardioblast proliferation

[Term]
id: GO:0003267
name: regulation of second heart field cardioblast proliferation by Wnt receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a target cell resulting in the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0003266 ! regulation of second heart field cardioblast proliferation
is_a: GO:0016055 ! Wnt receptor signaling pathway

[Term]
id: GO:0003268
name: regulation of second heart field cardioblast cell proliferation by fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0003266 ! regulation of second heart field cardioblast proliferation
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway

[Term]
id: GO:0003269
name: regulation of second heart field cardioblast proliferation by BMP signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor resulting in the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0003266 ! regulation of second heart field cardioblast proliferation
is_a: GO:0030509 ! BMP signaling pathway

[Term]
id: GO:0003270
name: regulation of second heart field cardioblast proliferation by Notch signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell resulting in the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0003266 ! regulation of second heart field cardioblast proliferation
is_a: GO:0007219 ! Notch signaling pathway

[Term]
id: GO:0003271
name: regulation of second heart field cardioblast proliferation by smoothened receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened resulting in the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
is_a: GO:0003266 ! regulation of second heart field cardioblast proliferation
is_a: GO:0007224 ! smoothened signaling pathway

[Term]
id: GO:0003272
name: endocardial cushion formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003203 ! endocardial cushion morphogenesis

[Term]
id: GO:0003273
name: cell migration involved in endocardial cushion formation
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
relationship: part_of GO:0003272 ! endocardial cushion formation

[Term]
id: GO:0003274
name: endocardial cushion fusion
namespace: biological_process
def: "The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping." [GOC:mtg_heart]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0003203 ! endocardial cushion morphogenesis

[Term]
id: GO:0003275
name: apoptosis involved in outflow tract morphogenesis
namespace: biological_process
def: "The apoptosis process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart]
is_a: GO:0003278 ! apoptosis involved in heart morphogenesis
relationship: part_of GO:0003151 ! outflow tract morphogenesis

[Term]
id: GO:0003276
name: apoptosis involved in heart valve morphogenesis
namespace: biological_process
def: "The apoptosis process that contributes to the shaping of a heart valve." [GOC:mtg_heart]
is_a: GO:0003278 ! apoptosis involved in heart morphogenesis
relationship: part_of GO:0003179 ! heart valve morphogenesis

[Term]
id: GO:0003277
name: apoptosis involved in endocardial cushion morphogenesis
namespace: biological_process
def: "The apoptosis process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]
is_a: GO:0003278 ! apoptosis involved in heart morphogenesis
relationship: part_of GO:0003203 ! endocardial cushion morphogenesis

[Term]
id: GO:0003278
name: apoptosis involved in heart morphogenesis
namespace: biological_process
def: "The process of apoptosis that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0060561 ! apoptosis involved in morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0003279
name: cardiac septum development
namespace: biological_process
def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart]
synonym: "heart septum development" EXACT [GOC:mtg_heart]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0003205 ! cardiac chamber development

[Term]
id: GO:0003281
name: ventricular septum development
namespace: biological_process
def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart]
synonym: "interventricular septum development" EXACT [GOC:mtg_heart]
synonym: "septum inferius development" NARROW [GOC:mtg_heart]
is_a: GO:0003279 ! cardiac septum development
relationship: part_of GO:0003231 ! cardiac ventricle development

[Term]
id: GO:0003282
name: ventricular septum intermedium development
namespace: biological_process
def: "The progression of the ventricular septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003281 ! ventricular septum development

[Term]
id: GO:0003283
name: atrial septum development
namespace: biological_process
def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003279 ! cardiac septum development
relationship: part_of GO:0003230 ! cardiac atrium development

[Term]
id: GO:0003284
name: septum primum development
namespace: biological_process
def: "The progression of the septum primum over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003283 ! atrial septum development

[Term]
id: GO:0003285
name: septum secundum development
namespace: biological_process
def: "The progression of the septum secundum over time, from its initial formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003283 ! atrial septum development

[Term]
id: GO:0003286
name: atrial septum intermedium development
namespace: biological_process
def: "The progression of the atrial septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart]
is_a: GO:0003283 ! atrial septum development

[Term]
id: GO:0003288
name: ventricular septum intermedium morphogenesis
namespace: biological_process
def: "The developmental process by which a ventricular septum intermedium is generated and organized." [GOC:mtg_heart]
is_a: GO:0060412 ! ventricular septum morphogenesis

[Term]
id: GO:0003289
name: atrial septum primum morphogenesis
namespace: biological_process
def: "The process by which anatomical structure of an atrial septum primum is generated and organized." [GOC:mtg_heart]
is_a: GO:0060413 ! atrial septum morphogenesis
relationship: part_of GO:0003284 ! septum primum development

[Term]
id: GO:0003290
name: atrial septum secundum morphogenesis
namespace: biological_process
def: "The process by which anatomical structure of an atrial septum secundum is generated and organized." [GOC:mtg_heart]
is_a: GO:0060413 ! atrial septum morphogenesis
relationship: part_of GO:0003285 ! septum secundum development

[Term]
id: GO:0003291
name: atrial septum intermedium morphogenesis
namespace: biological_process
def: "The process by which anatomical structure of an atrial septum intermedium is generated and organized." [GOC:mtg_heart]
is_a: GO:0060413 ! atrial septum morphogenesis
relationship: part_of GO:0003286 ! atrial septum intermedium development

[Term]
id: GO:0003292
name: cardiac septum cell differentiation
namespace: biological_process
def: "The process by which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart]
is_a: GO:0035051 ! cardiac cell differentiation
relationship: part_of GO:0003279 ! cardiac septum development

[Term]
id: GO:0003293
name: heart valve cell differentiation
namespace: biological_process
def: "The process by which an endocardial cushion cell give rise to a cell that is part of a heart valve." [GOC:mtg_heart]
is_a: GO:0035051 ! cardiac cell differentiation
relationship: part_of GO:0003170 ! heart valve development

[Term]
id: GO:0003294
name: atrial ventricular junction remodeling
namespace: biological_process
def: "The reorganization or renovation of heart tissue that contributes to the process by which the connection between an atrium and a ventricle matures." [GOC:mtg_heart]
synonym: "atrio-ventricular junction remodeling " RELATED [GOC:mtg_heart]
synonym: "atrioventricular junction remodeling " EXACT [GOC:mtg_heart]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0003295
name: cell proliferation involved in atrial ventricular junction remodeling
namespace: biological_process
def: "The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_heart]
synonym: "cell proliferation involved in atrio-ventricular junction remodeling " EXACT [GOC:mtg_heart]
synonym: "cell proliferation involved in atrioventricular junction remodeling" EXACT [GOC:mtg_heart]
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0003294 ! atrial ventricular junction remodeling

[Term]
id: GO:0003296
name: apoptosis involved in atrial ventricular junction remodeling
namespace: biological_process
def: "The process of apoptosis that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_heart]
synonym: "apoptosis involved in atrio-ventricular junction remodeling" EXACT [GOC:mtg_heart]
synonym: "apoptosis involved in atrioventricular junction remodeling " EXACT [GOC:mtg_heart]
is_a: GO:0003278 ! apoptosis involved in heart morphogenesis
relationship: part_of GO:0003294 ! atrial ventricular junction remodeling

[Term]
id: GO:0003297
name: heart wedging
namespace: biological_process
def: "The morphogenetic process by which the aorta inserts between the atrioventricular valves that contributes to the shaping of the heart." [GOC:mtg_heart]
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0003298
name: physiological muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart]
is_a: GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0003299
name: muscle hypertrophy in response to stress
namespace: biological_process
def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis." [GOC:mtg_heart]
is_a: GO:0006950 ! response to stress
is_a: GO:0014896 ! muscle hypertrophy
is_a: GO:0043500 ! muscle adaptation

[Term]
id: GO:0003300
name: cardiac muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart]
is_a: GO:0014897 ! striated muscle hypertrophy

[Term]
id: GO:0003301
name: physiological cardiac muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:mtg_heart]
is_a: GO:0003300 ! cardiac muscle hypertrophy
relationship: part_of GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0003302
name: transforming growth factor beta receptor signaling pathway involved in heart jogging
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to the process of heart jogging." [GOC:mtg_heart]
synonym: "nodal signaling involved in heart jogging" NARROW [GOC:mtg_heart]
is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway
relationship: part_of GO:0003146 ! heart jogging

[Term]
id: GO:0003303
name: BMP signaling pathway involved in heart jogging
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the process of heart jogging." [GOC:mtg_heart]
is_a: GO:0030509 ! BMP signaling pathway
relationship: part_of GO:0003146 ! heart jogging

[Term]
id: GO:0003304
name: myocardial epithelial involution involved in heart jogging
namespace: biological_process
def: "The morphogenetic process by which the myocardium bends along a linear axis and contributes to the process of heart jogging." [GOC:mtg_heart]
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0003146 ! heart jogging

[Term]
id: GO:0003305
name: cell migration involved in heart jogging
namespace: biological_process
def: "The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
relationship: part_of GO:0003146 ! heart jogging

[Term]
id: GO:0003306
name: Wnt receptor signaling pathway involved in heart development
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart]
is_a: GO:0016055 ! Wnt receptor signaling pathway
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0003307
name: regulation of Wnt receptor signaling pathway involved in heart development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart]
is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0003306 ! Wnt receptor signaling pathway involved in heart development

[Term]
id: GO:0003308
name: negative regulation of Wnt receptor signaling pathway involved in heart development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart]
is_a: GO:0003307 ! regulation of Wnt receptor signaling pathway involved in heart development
is_a: GO:0030178 ! negative regulation of Wnt receptor signaling pathway
relationship: negatively_regulates GO:0003306 ! Wnt receptor signaling pathway involved in heart development

[Term]
id: GO:0003309
name: pancreatic B cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features of a pancreatic beta cell. Beta cells are cells of the pancreas that secrete insulin." [GOC:dph, PMID:11076772]
synonym: "pancreatic beta cell differentiation" EXACT [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development

[Term]
id: GO:0003310
name: pancreatic A cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:11076772, GOC:dph]
synonym: "pancreatic alpha cell differentiation" EXACT [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development

[Term]
id: GO:0003311
name: pancreatic D cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:11076772, GOC:dph]
synonym: "pancreatic delta cell differentiation" EXACT [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development

[Term]
id: GO:0003312
name: pancreatic PP cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772]
synonym: "pancreatic polypeptide-producing cell differentiation" EXACT [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development

[Term]
id: GO:0003313
name: heart rudiment development
namespace: biological_process
def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart]
synonym: "heart cone development" EXACT [GOC:mtg_heart]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0035050 ! embryonic heart tube development

[Term]
id: GO:0003314
name: heart rudiment morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart]
synonym: "heart cone morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0003313 ! heart rudiment development

[Term]
id: GO:0003315
name: heart rudiment formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart]
synonym: "heart cone formation" EXACT [GOC:mtg_heart]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003314 ! heart rudiment morphogenesis

[Term]
id: GO:0003316
name: establishment of myocardial progenitor cell apical/basal polarity
namespace: biological_process
def: "The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment." [GOC:mtg_heart]
synonym: "myocardial progenitor epithelial polarization" EXACT [GOC:mtg_heart]
is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity
relationship: part_of GO:0003315 ! heart rudiment formation

[Term]
id: GO:0003317
name: cardioblast cell midline fusion
namespace: biological_process
def: "The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment." [GOC:mtg_heart]
synonym: "cardiac progenitor cell midline fusion" EXACT [GOC:mtg_heart]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0003315 ! heart rudiment formation

[Term]
id: GO:0003318
name: cell migration to the midline involved in heart development
namespace: biological_process
def: "The orderly movement of a cell toward the midline that contributes to the progression of the heart over time." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development

[Term]
id: GO:0003319
name: cardioblast migration to the midline involved in heart rudiment formation
namespace: biological_process
def: "The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment." [GOC:mtg_heart]
is_a: GO:0003318 ! cell migration to the midline involved in heart development
relationship: part_of GO:0003315 ! heart rudiment formation

[Term]
id: GO:0003320
name: heart rudiment involution
namespace: biological_process
def: "The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube." [GOC:mtg_heart]
is_a: GO:0003152 ! morphogenesis of an epithelial fold involved in embryonic heart tube formation

[Term]
id: GO:0003321
name: positive regulation of blood pressure by epinephrine-norepinephrine
namespace: biological_process
def: "Any process by which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine." [GOC:dph]
is_a: GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine
is_a: GO:0045777 ! positive regulation of blood pressure

[Term]
id: GO:0003322
name: pancreatic A cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph]
synonym: "pancreatic alpha cell development" EXACT [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0003310 ! pancreatic A cell differentiation

[Term]
id: GO:0003323
name: pancreatic B cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic B cell over time, from its formation to the mature structure. Beta cells are cells of the pancreas that secrete insulin." [GOC:dph]
synonym: "pancreatic beta cell development" EXACT [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0003309 ! pancreatic B cell differentiation

[Term]
id: GO:0003324
name: pancreatic D cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph]
synonym: "pancreatic delta cell development" EXACT [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0003311 ! pancreatic D cell differentiation

[Term]
id: GO:0003325
name: pancreatic PP cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0003312 ! pancreatic PP cell differentiation

[Term]
id: GO:0003326
name: pancreatic A cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0003310 ! pancreatic A cell differentiation

[Term]
id: GO:0003327
name: pancreatic B cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a pancreatic B cell fate and its capacity to differentiate into a pancreatic B cell. Beta cells are cells of the pancreas that secrete insulin." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0003309 ! pancreatic B cell differentiation

[Term]
id: GO:0003328
name: pancreatic D cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0003311 ! pancreatic D cell differentiation

[Term]
id: GO:0003329
name: pancreatic PP cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0003312 ! pancreatic PP cell differentiation

[Term]
id: GO:0003330
name: regulation of extracellular matrix constituent secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0070278 ! extracellular matrix constituent secretion

[Term]
id: GO:0003331
name: positive regulation of extracellular matrix constituent secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051047 ! positive regulation of secretion
relationship: positively_regulates GO:0070278 ! extracellular matrix constituent secretion

[Term]
id: GO:0003332
name: negative regulation of extracellular matrix constituent secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]
is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051048 ! negative regulation of secretion
relationship: negatively_regulates GO:0070278 ! extracellular matrix constituent secretion

[Term]
id: GO:0003333
name: amino acid transmembrane transport
namespace: biological_process
def: "The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane." [GOC:dph, GOC:tb]
is_a: GO:0006865 ! amino acid transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0003334
name: keratinocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0002064 ! epithelial cell development
is_a: GO:0030216 ! keratinocyte differentiation

[Term]
id: GO:0003335
name: corneocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis." [GOC:dph]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0003334 ! keratinocyte development

[Term]
id: GO:0003336
name: corneocyte desquamation
namespace: biological_process
def: "The negative regulation of cell adhesion process by which a corneocyte is shed from the surface of the epidermis." [GOC:dph]
synonym: "epidermal desquamation" EXACT [GOC:dph]
is_a: GO:0060232 ! delamination
relationship: part_of GO:0003335 ! corneocyte development

[Term]
id: GO:0003337
name: mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph]
synonym: "metanephric mesenchyme to epithelial transition" RELATED [GOC:dph]
is_a: GO:0060231 ! mesenchymal to epithelial transition
relationship: part_of GO:0072093 ! metanephric renal vesicle formation

[Term]
id: GO:0003338
name: metanephros morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the metanephros are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph]
is_a: GO:0060993 ! kidney morphogenesis
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0003339
name: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph]
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0090183 ! regulation of kidney development
relationship: regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis

[Term]
id: GO:0003340
name: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph]
is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation
relationship: negatively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis

[Term]
id: GO:0003341
name: cilium movement
namespace: biological_process
def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl]
synonym: "cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006928 ! cellular component movement
is_a: GO:0007018 ! microtubule-based movement

[Term]
id: GO:0003342
name: proepicardium development
namespace: biological_process
def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343]
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0003343 ! septum transversum development

[Term]
id: GO:0003343
name: septum transversum development
namespace: biological_process
def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343]
is_a: GO:0060485 ! mesenchyme development

[Term]
id: GO:0003344
name: pericardium morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343]
is_a: GO:0002011 ! morphogenesis of an epithelial sheet
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0060039 ! pericardium development

[Term]
id: GO:0003345
name: proepicardium cell migration involved in pericardium morphogenesis
namespace: biological_process
def: "The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart." [GOC:dph, PMID:18722343]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0003344 ! pericardium morphogenesis

[Term]
id: GO:0003346
name: epicardium-derived cell migration to the myocardium
namespace: biological_process
def: "The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium." [GOC:dph, PMID:18722343]
is_a: GO:0060973 ! cell migration involved in heart development

[Term]
id: GO:0003347
name: epicardial cell to mesenchymal cell transition
namespace: biological_process
def: "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium." [GOC:dph, PMID:18722343]
is_a: GO:0001837 ! epithelial to mesenchymal transition

[Term]
id: GO:0003348
name: cardiac endothelial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343]
is_a: GO:0035051 ! cardiac cell differentiation

[Term]
id: GO:0003349
name: epicardium-derived cardiac endothelial cell differentiation
namespace: biological_process
def: "The process whereby an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343]
is_a: GO:0003348 ! cardiac endothelial cell differentiation

[Term]
id: GO:0003350
name: pulmonary myocardium development
namespace: biological_process
def: "The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein." [GOC:dph, PMID:17638577]
is_a: GO:0014706 ! striated muscle tissue development
relationship: part_of GO:0060841 ! venous blood vessel development

[Term]
id: GO:0003351
name: epithelial cilium movement
namespace: biological_process
def: "The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid." [GOC:dph]
synonym: "epithelial cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003341 ! cilium movement

[Term]
id: GO:0003352
name: regulation of cilium movement
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
is_a: GO:0051270 ! regulation of cellular component movement
is_a: GO:0060632 ! regulation of microtubule-based movement
relationship: regulates GO:0003341 ! cilium movement

[Term]
id: GO:0003353
name: positive regulation of cilium movement
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:0051272 ! positive regulation of cellular component movement
relationship: positively_regulates GO:0003341 ! cilium movement

[Term]
id: GO:0003354
name: negative regulation of cilium movement
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:0051271 ! negative regulation of cellular component movement
relationship: negatively_regulates GO:0003341 ! cilium movement

[Term]
id: GO:0003355
name: cilium movement involved in otolith formation
namespace: biological_process
def: "The directed, self-propelled movement of a cilium of an inner ear epithelial cell, resulting the aggregation of otolith seed particles." [GOC:dph]
is_a: GO:0003351 ! epithelial cilium movement
relationship: part_of GO:0032475 ! otolith formation

[Term]
id: GO:0003356
name: regulation of cilium beat frequency
namespace: biological_process
def: "Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]
is_a: GO:0003352 ! regulation of cilium movement

[Term]
id: GO:0003357
name: noradrenergic neuron differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph]
synonym: "norepinephrine secreting neuron differentiation" EXACT [GOC:dph]
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0003358
name: noradrenergic neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
synonym: "norepinephrine secreting neuron development" EXACT [GOC:dph]
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0003357 ! noradrenergic neuron differentiation

[Term]
id: GO:0003359
name: noradrenergic neuron fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron." [GOC:dph]
synonym: "norepinephrine secreting neuron fate commitment" EXACT [GOC:dph]
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0003357 ! noradrenergic neuron differentiation

[Term]
id: GO:0003360
name: brainstem development
namespace: biological_process
def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0003361
name: noradrenergic neuron differentiation involved in brainstem development
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph]
is_a: GO:0003357 ! noradrenergic neuron differentiation
relationship: part_of GO:0003360 ! brainstem development

[Term]
id: GO:0003362
name: noradrenergic neuron fate commitment involved in brainstem development
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem." [GOC:dph]
is_a: GO:0003359 ! noradrenergic neuron fate commitment
relationship: part_of GO:0003361 ! noradrenergic neuron differentiation involved in brainstem development

[Term]
id: GO:0003363
name: lamellipodium assembly involved in ameboidal cell migration
namespace: biological_process
def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030032 ! lamellipodium assembly
relationship: part_of GO:0001667 ! ameboidal cell migration

[Term]
id: GO:0003364
name: lamellipodium assembly involved in mesendodermal cell migration
namespace: biological_process
def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003363 ! lamellipodium assembly involved in ameboidal cell migration
relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration

[Term]
id: GO:0003365
name: establishment of cell polarity involved in ameboidal cell migration
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030010 ! establishment of cell polarity
relationship: part_of GO:0001667 ! ameboidal cell migration

[Term]
id: GO:0003366
name: cell-matrix adhesion involved in ameboidal cell migration
namespace: biological_process
def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007160 ! cell-matrix adhesion
relationship: part_of GO:0001667 ! ameboidal cell migration

[Term]
id: GO:0003367
name: cell-cell adhesion involved in ameboidal cell migration
namespace: biological_process
def: "The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration

[Term]
id: GO:0003368
name: cell-matrix adhesion involved in mesendodermal cell migration
namespace: biological_process
def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003366 ! cell-matrix adhesion involved in ameboidal cell migration
relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration

[Term]
id: GO:0003369
name: establishment of cell polarity involved in mesendodermal cell migration
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration
relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration

[Term]
id: GO:0003370
name: cell-cell adhesion involved in mesendodermal cell migration
namespace: biological_process
def: "The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003367 ! cell-cell adhesion involved in ameboidal cell migration
relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration

[Term]
id: GO:0003371
name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity
relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration

[Term]
id: GO:0003372
name: establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003380 ! establishment or maintenance of cytoskeleton polarity involved in gastrulation
relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration

[Term]
id: GO:0003373
name: dynamin polymerization involved in membrane fission
namespace: biological_process
def: "The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051258 ! protein polymerization
relationship: part_of GO:0090148 ! membrane fission

[Term]
id: GO:0003374
name: dynamin polymerization involved in mitochondrial fission
namespace: biological_process
def: "The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003373 ! dynamin polymerization involved in membrane fission

[Term]
id: GO:0003375
name: regulation of dynamin polymerization involved in membrane fission
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032271 ! regulation of protein polymerization
relationship: regulates GO:0003373 ! dynamin polymerization involved in membrane fission

[Term]
id: GO:0003376
name: sphingolipid signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by a sphingolipid." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007242 ! intracellular signaling cascade

[Term]
id: GO:0003377
name: regulation of apoptosis by sphingolipid signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by a sphingolipid that modulates the rate, frequency, or extent of apoptosis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003376 ! sphingolipid signaling pathway
is_a: GO:0042981 ! regulation of apoptosis

[Term]
id: GO:0003378
name: regulation of inflammatory response by sphingolipid signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by a sphingolipid that modulates the rate, frequency, or extent of the inflammatory response." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003376 ! sphingolipid signaling pathway
is_a: GO:0050727 ! regulation of inflammatory response

[Term]
id: GO:0003379
name: establishment of cell polarity involved in gastrulation cell migration
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration
relationship: part_of GO:0042074 ! cell migration involved in gastrulation

[Term]
id: GO:0003380
name: establishment or maintenance of cytoskeleton polarity involved in gastrulation
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
relationship: part_of GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration

[Term]
id: GO:0003381
name: epithelial cell morphogenesis involved in gastrulation
namespace: biological_process
def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003382 ! epithelial cell morphogenesis
is_a: GO:0007369 ! gastrulation

[Term]
id: GO:0003382
name: epithelial cell morphogenesis
namespace: biological_process
def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0002064 ! epithelial cell development

[Term]
id: GO:0003383
name: apical constriction
namespace: biological_process
def: "The actin-mediated process by which the apical end of a polarized columnar epithelial cell contracts." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0070252 ! actin-mediated cell contraction
relationship: part_of GO:0003382 ! epithelial cell morphogenesis

[Term]
id: GO:0003384
name: apical constriction involved in gastrulation
namespace: biological_process
def: "The actin-mediated process by which the apical end of a polarized columnar epithelial cell contracts, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003383 ! apical constriction
relationship: part_of GO:0003381 ! epithelial cell morphogenesis involved in gastrulation

[Term]
id: GO:0003385
name: cell-cell signaling involved in amphid sensory organ development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0003386 ! amphid sensory organ development

[Term]
id: GO:0003386
name: amphid sensory organ development
namespace: biological_process
def: "The progression of the amphid sensory organ over time, from it's formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0003387
name: neuron differentiation involved in amphid sensory organ development
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0003386 ! amphid sensory organ development

[Term]
id: GO:0003388
name: neuron development involved in amphid sensory organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0003387 ! neuron differentiation involved in amphid sensory organ development

[Term]
id: GO:0003389
name: retrograde extension
namespace: biological_process
def: "The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0031175 ! neuron projection development

[Term]
id: GO:0003390
name: dendrite development by retrograde extension
namespace: biological_process
def: "The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "dendrite retrograde extension" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003389 ! retrograde extension
is_a: GO:0016358 ! dendrite development

[Term]
id: GO:0003391
name: amphid sensory organ dendrite retrograde extension
namespace: biological_process
def: "The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003390 ! dendrite development by retrograde extension
relationship: part_of GO:0003388 ! neuron development involved in amphid sensory organ development

[Term]
id: GO:0003392
name: cell adhesion involved in retrograde extension
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007155 ! cell adhesion
relationship: part_of GO:0003389 ! retrograde extension

[Term]
id: GO:0003393
name: neuron migration involved in retrograde extension
namespace: biological_process
def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0001764 ! neuron migration
relationship: part_of GO:0003389 ! retrograde extension

[Term]
id: GO:0003394
name: cell adhesion involved in dendrite retrograde extension
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003392 ! cell adhesion involved in retrograde extension
relationship: part_of GO:0003390 ! dendrite development by retrograde extension

[Term]
id: GO:0003395
name: neuron migration involved in dendrite retrograde extension
namespace: biological_process
def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003393 ! neuron migration involved in retrograde extension
relationship: part_of GO:0003390 ! dendrite development by retrograde extension

[Term]
id: GO:0003396
name: cell adhesion involved in amphid sensory organ dendrite retrograde extension
namespace: biological_process
def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003394 ! cell adhesion involved in dendrite retrograde extension
relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension

[Term]
id: GO:0003397
name: neuron migration involved in amphid sensory organ dendrite retrograde extension
namespace: biological_process
def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003395 ! neuron migration involved in dendrite retrograde extension
relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension

[Term]
id: GO:0003398
name: glial cell differentiation involved in amphid sensory organ development
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003386 ! amphid sensory organ development
is_a: GO:0010001 ! glial cell differentiation

[Term]
id: GO:0003399
name: cytoneme morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048858 ! cell projection morphogenesis

[Term]
id: GO:0003400
name: regulation of COPII vesicle coating
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jpark, GOC:tb]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0048209 ! regulation of vesicle targeting, to, from or within Golgi
is_a: GO:0090113 ! regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis
relationship: regulates GO:0048208 ! COPII vesicle coating

[Term]
id: GO:0003401
name: axis elongation
namespace: biological_process
def: "The developmental growth that results in the elongation of a straight line that defines polarity or symmetry in an anatomical structure." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "elongation of an axis" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060560 ! developmental growth involved in morphogenesis

[Term]
id: GO:0003402
name: planar cell polarity pathway involved in axis elongation
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway
relationship: part_of GO:0003401 ! axis elongation

[Term]
id: GO:0003403
name: optic vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003404 ! optic vesicle morphogenesis
relationship: part_of GO:0060900 ! embryonic camera-type eye formation

[Term]
id: GO:0003404
name: optic vesicle morphogenesis
namespace: biological_process
def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis

[Term]
id: GO:0003405
name: optic vesicle elongation
namespace: biological_process
def: "The developmental growth that results in the lengthening of the optic vesicle in the posterior direction." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0003404 ! optic vesicle morphogenesis

[Term]
id: GO:0003406
name: retinal pigment epithelium development
namespace: biological_process
def: "The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "RPE development" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0060041 ! retina development in camera-type eye

[Term]
id: GO:0003407
name: neural retina development
namespace: biological_process
def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060041 ! retina development in camera-type eye

[Term]
id: GO:0003408
name: optic cup formation involved in camera-type eye development
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development

[Term]
id: GO:0003409
name: optic cup structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development

[Term]
id: GO:0003410
name: anterior rotation of the optic cup
namespace: biological_process
def: "A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0003411
name: cell motility involved in camera-type eye morphogenesis
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048870 ! cell motility
relationship: part_of GO:0048593 ! camera-type eye morphogenesis

[Term]
id: GO:0003412
name: establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis
namespace: biological_process
def: "The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity

[Term]
id: GO:0003413
name: chondrocyte differentiation involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process whereby a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0002062 ! chondrocyte differentiation
relationship: part_of GO:0060351 ! cartilage development involved in endochondral bone morphogenesis

[Term]
id: GO:0003414
name: chondrocyte morphogenesis involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process by which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090171 ! chondrocyte morphogenesis
relationship: part_of GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis

[Term]
id: GO:0003415
name: chondrocyte hypertrophy
namespace: biological_process
def: "The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0002063 ! chondrocyte development

[Term]
id: GO:0003416
name: endochondral bone growth
namespace: biological_process
def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060350 ! endochondral bone morphogenesis

[Term]
id: GO:0003417
name: growth plate cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060351 ! cartilage development involved in endochondral bone morphogenesis
relationship: part_of GO:0003416 ! endochondral bone growth

[Term]
id: GO:0003418
name: growth plate cartilage chondrocyte differentiation
namespace: biological_process
def: "The process whereby a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis
relationship: part_of GO:0003417 ! growth plate cartilage development

[Term]
id: GO:0003419
name: growth plate cartilage chondrocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0003417 ! growth plate cartilage development

[Term]
id: GO:0003420
name: regulation of growth plate cartilage chondrocyte proliferation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0061035 ! regulation of cartilage development
relationship: regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation

[Term]
id: GO:0003421
name: growth plate cartilage axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "growth plate cartilage axis determination" RELATED [GOC:dph]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis

[Term]
id: GO:0003422
name: growth plate cartilage morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060536 ! cartilage morphogenesis
relationship: part_of GO:0003417 ! growth plate cartilage development

[Term]
id: GO:0003423
name: growth plate cartilage chondrocyte division
namespace: biological_process
def: "The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051301 ! cell division
relationship: part_of GO:0003419 ! growth plate cartilage chondrocyte proliferation

[Term]
id: GO:0003424
name: establishment of cell polarity involved in growth plate cartilage chondrocyte division
namespace: biological_process
def: "The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "growth plate cartilage chondrocyte polarization" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030010 ! establishment of cell polarity
relationship: part_of GO:0003423 ! growth plate cartilage chondrocyte division

[Term]
id: GO:0003425
name: establishment of spindle orientation involved in growth plate cartilage chondrocyte division
namespace: biological_process
def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000132 ! establishment of mitotic spindle orientation
is_a: GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division

[Term]
id: GO:0003426
name: cytoskeleton polarization involved in growth plate cartilage chondrocyte division
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007010 ! cytoskeleton organization
relationship: part_of GO:0003424 ! establishment of cell polarity involved in growth plate cartilage chondrocyte division

[Term]
id: GO:0003427
name: regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003420 ! regulation of growth plate cartilage chondrocyte proliferation
is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity
is_a: GO:0051302 ! regulation of cell division
is_a: GO:0051493 ! regulation of cytoskeleton organization
is_a: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway
relationship: regulates GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division

[Term]
id: GO:0003428
name: chondrocyte intercalation involved in growth plate cartilage morphogenesis
namespace: biological_process
def: "The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016477 ! cell migration
is_a: GO:0060026 ! convergent extension
relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis

[Term]
id: GO:0003429
name: growth plate cartilage chondrocyte morphogenesis
namespace: biological_process
def: "The process by which the structures of a chondrocyte in the growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003414 ! chondrocyte morphogenesis involved in endochondral bone morphogenesis
relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation

[Term]
id: GO:0003430
name: growth plate cartilage chondrocyte growth
namespace: biological_process
def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "growth plate cartilage chondrocyte hypertrophy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003415 ! chondrocyte hypertrophy
relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development

[Term]
id: GO:0003431
name: growth plate cartilage chondrocyte development
namespace: biological_process
def: "The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis
relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation

[Term]
id: GO:0003432
name: cell growth involved in growth plate cartilage chondrocyte morphogensis
namespace: biological_process
def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003430 ! growth plate cartilage chondrocyte growth
relationship: part_of GO:0003429 ! growth plate cartilage chondrocyte morphogenesis

[Term]
id: GO:0003433
name: chondrocyte development involved in endochondral bone morphogenesis
namespace: biological_process
def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0002063 ! chondrocyte development
relationship: part_of GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis

[Term]
id: GO:0003434
name: BMP signaling pathway involved in growth plate cartilage chondrocyte development
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030509 ! BMP signaling pathway
relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development

[Term]
id: GO:0003435
name: smoothened signaling pathway involved in growth plate cartilage chondrocyte development
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007224 ! smoothened signaling pathway
relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development

[Term]
id: GO:0003436
name: regulation of cell adhesion involved in growth plate cartilage morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030155 ! regulation of cell adhesion
relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis

[Term]
id: GO:0003437
name: regulation of cell communication involved in growth plate cartilage morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis

[Term]
id: GO:0003673
name: Gene_Ontology
namespace: biological_process
def: "OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
is_obsolete: true

[Term]
id: GO:0003674
name: molecular_function
namespace: molecular_function
alt_id: GO:0005554
def: "Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions." [GOC:go_curators]
comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "molecular function" EXACT []
synonym: "molecular function unknown" NARROW []

[Term]
id: GO:0003675
name: protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0003676
name: nucleic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl]
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0003677
name: DNA binding
namespace: molecular_function
def: "Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "microtubule/chromatin interaction" RELATED []
synonym: "plasmid binding" NARROW []
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0003678
name: DNA helicase activity
namespace: molecular_function
alt_id: GO:0003679
def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah, http://cancerweb.ncl.ac.uk/]
comment: Consider also annotating to the molecular function term 'DNA binding ; GO:0003677'.
subset: gosubset_prok
is_a: GO:0004386 ! helicase activity

[Term]
id: GO:0003680
name: AT DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [GOC:jl, PMID:2670564]
synonym: "AT binding" EXACT []
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0003681
name: bent DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA in a bent conformation." [GOC:jl, PMID:12627977]
subset: gosubset_prok
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0003682
name: chromatin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
synonym: "lamin/chromatin binding" BROAD []
synonym: "microtubule/chromatin interaction" RELATED []
synonym: "nuclear membrane vesicle binding to chromatin" NARROW []
is_a: GO:0005488 ! binding

[Term]
id: GO:0003683
name: lamin/chromatin binding
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents two functions.
is_obsolete: true
replaced_by: GO:0003682
replaced_by: GO:0005521

[Term]
id: GO:0003684
name: damaged DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with damaged DNA." [GOC:jl]
subset: gosubset_prok
synonym: "DNA repair enzyme" RELATED []
synonym: "DNA repair protein" RELATED []
xref: Reactome:7372 "damaged DNA binding"
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0003685
name: DNA repair protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it includes a process term.
is_obsolete: true
consider: GO:0003684

[Term]
id: GO:0003686
name: DNA repair enzyme
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it includes a process term.
is_obsolete: true
consider: GO:0003684

[Term]
id: GO:0003687
name: DNA replication factor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it does not represent a true molecular function.
is_obsolete: true
consider: GO:0006260

[Term]
id: GO:0003688
name: DNA replication origin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "ARS binding" NARROW []
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0003689
name: DNA clamp loader activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778]
subset: gosubset_prok
synonym: "DNA clamp loading ATPase activity" EXACT []
synonym: "PCNA loading activity" NARROW []
synonym: "PCNA loading complex activity" NARROW []
xref: Reactome:9823 "DNA clamp loader activity"
is_a: GO:0003677 ! DNA binding
is_a: GO:0033170 ! protein-DNA loading ATPase activity

[Term]
id: GO:0003690
name: double-stranded DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA." [GOC:elh]
subset: gosubset_prok
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0003691
name: double-stranded telomeric DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382]
is_a: GO:0003690 ! double-stranded DNA binding
is_a: GO:0042162 ! telomeric DNA binding

[Term]
id: GO:0003692
name: left-handed Z-DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags." [ISBN:0716720094]
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0003693
name: P-element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any P-element, a class of Drosophila transposon responsible for hybrid dysgenesis." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0003694
name: plasmid binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it refers to component information.
synonym: "plasmid-associated protein" RELATED []
is_obsolete: true
consider: GO:0003677
consider: GO:0005727

[Term]
id: GO:0003695
name: random coil DNA binding
namespace: molecular_function
alt_id: GO:0016017
def: "Interacting selectively and non-covalently with DNA in a random coil configuration." [GOC:mah]
synonym: "random coil binding" EXACT []
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0003696
name: satellite DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA." [GOC:jl, SO:0000005]
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0003697
name: single-stranded DNA binding
namespace: molecular_function
alt_id: GO:0003698
alt_id: GO:0003699
def: "Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh]
subset: gosubset_prok
synonym: "ssDNA binding" EXACT [GOC:mah]
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0003700
name: transcription factor activity
namespace: molecular_function
alt_id: GO:0000130
def: "The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators]
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
xref: Reactome:4325 "transcription factor activity"
is_a: GO:0003677 ! DNA binding
is_a: GO:0030528 ! transcription regulator activity

[Term]
id: GO:0003701
name: RNA polymerase I transcription factor activity
namespace: molecular_function
def: "Functions to initiate or regulate RNA polymerase I transcription." [GOC:jl]
is_a: GO:0030528 ! transcription regulator activity

[Term]
id: GO:0003702
name: RNA polymerase II transcription factor activity
namespace: molecular_function
def: "Functions to initiate or regulate RNA polymerase II transcription." [GOC:jl]
is_a: GO:0030528 ! transcription regulator activity

[Term]
id: GO:0003704
name: specific RNA polymerase II transcription factor activity
namespace: molecular_function
def: "Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II." [GOC:ma]
is_a: GO:0003702 ! RNA polymerase II transcription factor activity

[Term]
id: GO:0003705
name: RNA polymerase II transcription factor activity, enhancer binding
namespace: molecular_function
def: "Functions to initiate or regulate RNA polymerase II transcription by binding an enhancer region of DNA." [GOC:jl]
is_a: GO:0003700 ! transcription factor activity
is_a: GO:0003702 ! RNA polymerase II transcription factor activity
is_a: GO:0035326 ! enhancer binding

[Term]
id: GO:0003706
name: ligand-regulated transcription factor activity
namespace: molecular_function
is_a: GO:0003704 ! specific RNA polymerase II transcription factor activity

[Term]
id: GO:0003707
name: steroid hormone receptor activity
namespace: molecular_function
def: "Combining with a steroid hormone to initiate a change in cell activity." [GOC:ai]
comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'.
is_a: GO:0004879 ! ligand-dependent nuclear receptor activity

[Term]
id: GO:0003708
name: retinoic acid receptor activity
namespace: molecular_function
def: "Combining with retinoic acid to initiate a change in cell activity. Retinoic acid is one of the forms of vitamin A." [GOC:ai]
comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'.
synonym: "vitamin A receptor activity" BROAD []
is_a: GO:0004879 ! ligand-dependent nuclear receptor activity

[Term]
id: GO:0003709
name: RNA polymerase III transcription factor activity
namespace: molecular_function
def: "Functions to initiate or regulate RNA polymerase III transcription." [GOC:jl]
is_a: GO:0030528 ! transcription regulator activity

[Term]
id: GO:0003711
name: transcription elongation regulator activity
namespace: molecular_function
def: "Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah]
subset: gosubset_prok
synonym: "transcription elongation factor activity" EXACT []
synonym: "transcriptional elongation regulator activity" EXACT []
is_a: GO:0030528 ! transcription regulator activity

[Term]
id: GO:0003712
name: transcription cofactor activity
namespace: molecular_function
def: "The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself." [PMID:10213677]
subset: gosubset_prok
synonym: "transcriptional co-regulator" EXACT []
synonym: "transcriptional cofactor activity" EXACT []
is_a: GO:0008134 ! transcription factor binding
is_a: GO:0030528 ! transcription regulator activity

[Term]
id: GO:0003713
name: transcription coactivator activity
namespace: molecular_function
def: "The function of a transcription cofactor that activates transcription from a RNA polymerase II promoter; does not bind DNA itself." [GOC:ma]
subset: gosubset_prok
synonym: "transcription co-activator activity" EXACT []
is_a: GO:0003712 ! transcription cofactor activity
is_a: GO:0016563 ! transcription activator activity

[Term]
id: GO:0003714
name: transcription corepressor activity
namespace: molecular_function
def: "The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself." [GOC:ma]
synonym: "transcription co-repressor activity" EXACT []
is_a: GO:0003712 ! transcription cofactor activity
is_a: GO:0016564 ! transcription repressor activity

[Term]
id: GO:0003715
name: transcription termination factor activity
namespace: molecular_function
def: "Any activity that brings about termination of transcription." [GOC:mah]
subset: gosubset_prok
synonym: "transcriptional termination factor activity" EXACT []
is_a: GO:0030528 ! transcription regulator activity

[Term]
id: GO:0003716
name: RNA polymerase I transcription termination factor activity
namespace: molecular_function
def: "Any activity that brings about termination of transcription by RNA polymerase I." [GOC:mah]
synonym: "Pol I transcription termination factor activity" EXACT []
is_a: GO:0003715 ! transcription termination factor activity

[Term]
id: GO:0003717
name: RNA polymerase II transcription termination factor activity
namespace: molecular_function
def: "Any activity that brings about termination of transcription by RNA polymerase II." [GOC:mah]
synonym: "Pol II transcription termination factor activity" EXACT []
is_a: GO:0003715 ! transcription termination factor activity

[Term]
id: GO:0003718
name: RNA polymerase III transcription termination factor activity
namespace: molecular_function
def: "Any activity that brings about termination of transcription by RNA polymerase III." [GOC:mah]
synonym: "Pol III transcription termination factor activity" EXACT []
is_a: GO:0003715 ! transcription termination factor activity

[Term]
id: GO:0003719
name: transcription factor binding, cytoplasmic sequestering
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because sequestering is a process rather than a function.
is_obsolete: true
replaced_by: GO:0042994

[Term]
id: GO:0003720
name: telomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:krc]
comment: Consider also annotating to the molecular function term 'telomeric DNA binding ; GO:0042162'.
xref: EC:2.7.7.-
xref: Reactome:10567 "telomerase activity"
is_a: GO:0003964 ! RNA-directed DNA polymerase activity

[Term]
id: GO:0003721
name: telomeric template RNA reverse transcriptase activity
namespace: molecular_function
def: "Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template." [EC:2.7.7.49, PMID:11812242]
synonym: "telomerase, catalyst" EXACT []
is_a: GO:0003964 ! RNA-directed DNA polymerase activity
relationship: part_of GO:0003720 ! telomerase activity

[Term]
id: GO:0003723
name: RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:1805 "RNA binding"
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0003724
name: RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah]
comment: Consider also annotating to the molecular function term 'RNA binding ; GO:0003723'.
subset: gosubset_prok
xref: EC:2.7.7.-
xref: Reactome:7008 "RNA helicase activity"
is_a: GO:0004386 ! helicase activity

[Term]
id: GO:0003725
name: double-stranded RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl]
subset: gosubset_prok
synonym: "dsDNA binding" EXACT [GOC:ecd]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0003726
name: double-stranded RNA adenosine deaminase activity
namespace: molecular_function
alt_id: GO:0003971
def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule." [GOC:mah]
subset: gosubset_prok
synonym: "double-stranded RNA specific editase activity" RELATED []
xref: Reactome:10576 "double-stranded RNA adenosine deaminase activity"
is_a: GO:0004000 ! adenosine deaminase activity

[Term]
id: GO:0003727
name: single-stranded RNA binding
namespace: molecular_function
alt_id: GO:0003728
def: "Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl]
synonym: "ssRNA binding" EXACT [GOC:mah]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0003729
name: mRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA) or messenger RNA (mRNA)." [GOC:jl]
subset: gosubset_prok
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0003730
name: mRNA 3'-UTR binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah]
synonym: "mRNA 3' UTR binding" EXACT []
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:0003731
name: mRNA cap binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript." [GOC:mah]
comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to.
is_obsolete: true
consider: GO:0000339

[Term]
id: GO:0003732
name: snRNA cap binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule." [GOC:mah]
comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to.
is_obsolete: true
consider: GO:0000339

[Term]
id: GO:0003733
name: ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
is_obsolete: true
replaced_by: GO:0030529

[Term]
id: GO:0003734
name: small nuclear ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
synonym: "snRNP" EXACT []
is_obsolete: true
replaced_by: GO:0030532

[Term]
id: GO:0003735
name: structural constituent of ribosome
namespace: molecular_function
alt_id: GO:0003736
alt_id: GO:0003737
alt_id: GO:0003738
alt_id: GO:0003739
alt_id: GO:0003740
alt_id: GO:0003741
alt_id: GO:0003742
def: "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah]
comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins.
subset: gosubset_prok
synonym: "ribosomal protein" BROAD []
synonym: "ribosomal RNA" RELATED []
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0003743
name: translation initiation factor activity
namespace: molecular_function
alt_id: GO:0003744
alt_id: GO:0003745
def: "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: Reactome:10611 "translation initiation factor activity"
is_a: GO:0008135 ! translation factor activity, nucleic acid binding

[Term]
id: GO:0003746
name: translation elongation factor activity
namespace: molecular_function
alt_id: GO:0008182
alt_id: GO:0008183
def: "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: Reactome:10616 "translation elongation factor activity"
is_a: GO:0008135 ! translation factor activity, nucleic acid binding

[Term]
id: GO:0003747
name: translation release factor activity
namespace: molecular_function
alt_id: GO:0003748
alt_id: GO:0003749
def: "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0008079 ! translation termination factor activity

[Term]
id: GO:0003750
name: cell cycle regulator
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it does not represent a single molecular function.
is_obsolete: true
replaced_by: GO:0051726

[Term]
id: GO:0003754
name: chaperone activity
namespace: molecular_function
alt_id: GO:0003757
alt_id: GO:0003758
alt_id: GO:0003760
alt_id: GO:0003761
def: "OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function." [ISBN:0198547684]
comment: This term was made obsolete because, as defined, it represents a class of gene products rather than a molecular function. The term string is also ambiguous, having connotations of involvement in transport processes.
is_obsolete: true
consider: GO:0006457
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0003755
name: peptidyl-prolyl cis-trans isomerase activity
namespace: molecular_function
alt_id: GO:0004752
alt_id: GO:0042028
def: "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]
subset: gosubset_prok
synonym: "cis-trans proline isomerase activity" EXACT []
synonym: "cyclophilin activity" RELATED [EC:5.2.1.8]
synonym: "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" NARROW []
synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" NARROW []
synonym: "immunophilin" RELATED []
synonym: "juglone-sensitive cis-trans proline isomerase activity" NARROW [GOC:mah]
synonym: "juglone-sensitive peptidyl-prolyl cis-trans isomerase activity" NARROW [GOC:mah]
synonym: "parvulin" RELATED []
synonym: "peptide bond isomerase activity" EXACT [EC:5.2.1.8]
synonym: "peptidyl-prolyl isomerase B reaction" RELATED []
synonym: "peptidylproline cis-trans-isomerase activity" EXACT [EC:5.2.1.8]
synonym: "peptidylprolyl cis-trans isomerase activity" EXACT [EC:5.2.1.8]
synonym: "peptidylprolyl isomerase activity" EXACT [EC:5.2.1.8]
synonym: "PPIase activity" EXACT [EC:5.2.1.8]
synonym: "rotamase activity" EXACT [EC:5.2.1.8]
xref: EC:5.2.1.8
xref: MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0003756
name: protein disulfide isomerase activity
namespace: molecular_function
def: "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1]
subset: gosubset_prok
synonym: "protein cysteine-thiol oxidation" RELATED []
synonym: "protein disulfide-isomerase" BROAD [EC:5.3.4.1]
synonym: "protein disulfide-isomerase reaction" EXACT [EC:5.3.4.1]
synonym: "protein disulphide isomerase activity" EXACT []
synonym: "S-S rearrangase activity" RELATED [EC:5.3.4.1]
xref: EC:5.3.4.1
xref: MetaCyc:5.3.4.1-RXN
is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups
is_a: GO:0016864 ! intramolecular oxidoreductase activity, transposing S-S bonds

[Term]
id: GO:0003759
name: glycoprotein-specific chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins." [GOC:jl, PMID:11337494]
comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function.
is_obsolete: true
consider: GO:0006457
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0003762
name: histone-specific chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function." [GOC:jl, PMID:7600578, PMID:9325046]
comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function.
synonym: "nucleosome assembly chaperone" EXACT []
is_obsolete: true
consider: GO:0006333
consider: GO:0006334
consider: GO:0034728
consider: GO:0042393
consider: GO:0043486
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0003763
name: chaperonin ATPase activity
namespace: molecular_function
alt_id: GO:0003764
alt_id: GO:0003765
alt_id: GO:0003766
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9, ISBN:0198547684]
comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information.
synonym: "chaperonin" EXACT []
is_obsolete: true
replaced_by: GO:0042623
consider: GO:0006457

[Term]
id: GO:0003767
name: co-chaperone activity
namespace: molecular_function
alt_id: GO:0003768
alt_id: GO:0003769
alt_id: GO:0003770
alt_id: GO:0003771
def: "OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity." [GOC:rb]
comment: This term was made obsolete because it represents a class of gene products rather than a molecular function.
is_obsolete: true
consider: GO:0006457
consider: GO:0044183
consider: GO:0051087

[Term]
id: GO:0003772
name: co-chaperonin activity
namespace: molecular_function
def: "OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity." [GOC:rb]
comment: This term was made obsolete because it represents a class of gene products rather than a molecular function.
is_obsolete: true
consider: GO:0006457
consider: GO:0044183
consider: GO:0051087

[Term]
id: GO:0003773
name: heat shock protein activity
namespace: molecular_function
def: "OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones." [ISBN:0198547684]
comment: This term was made obsolete because it represents a class of gene products rather than a molecular function.
is_obsolete: true
consider: GO:0006986
consider: GO:0042026

[Term]
id: GO:0003774
name: motor activity
namespace: molecular_function
def: "Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0017111 ! nucleoside-triphosphatase activity

[Term]
id: GO:0003775
name: axonemal motor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes cellular component information.
is_obsolete: true
consider: GO:0003777
consider: GO:0005930

[Term]
id: GO:0003776
name: muscle motor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes anatomy information.
is_obsolete: true
replaced_by: GO:0000146
consider: GO:0006936
consider: GO:0043292

[Term]
id: GO:0003777
name: microtubule motor activity
namespace: molecular_function
def: "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]
comment: Consider also annotating to the molecular function term 'microtubule binding ; GO:0008017'.
synonym: "axonemal motor activity" NARROW []
synonym: "dynein" BROAD []
synonym: "dynein ATPase activity" NARROW []
synonym: "kinesin" BROAD []
synonym: "kinesin motor activity" NARROW []
synonym: "kinetochore motor activity" NARROW []
xref: Reactome:10659 "microtubule motor activity"
is_a: GO:0003774 ! motor activity

[Term]
id: GO:0003778
name: dynactin motor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd]
comment: This term was made obsolete because the dynactin complex is not a motor as such, but does regulate the dynein motor complex.
is_obsolete: true

[Term]
id: GO:0003779
name: actin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]
subset: goslim_generic
synonym: "membrane associated actin binding" NARROW []
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0003780
name: actin cross-linking activity
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with two actin filaments to anchor them together." [GOC:jic]
comment: This term was made obsolete because it represents a combination of molecular functions.
is_obsolete: true
replaced_by: GO:0030674
replaced_by: GO:0051015

[Term]
id: GO:0003781
name: actin bundling activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
is_obsolete: true
replaced_by: GO:0051017

[Term]
id: GO:0003782
name: F-actin capping activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a biological process.
is_obsolete: true
replaced_by: GO:0051016

[Term]
id: GO:0003783
name: barbed-end actin capping activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a biological process.
is_obsolete: true
replaced_by: GO:0051016

[Term]
id: GO:0003784
name: barbed-end actin capping/severing activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes two biological processes.
is_obsolete: true
replaced_by: GO:0051014
replaced_by: GO:0051016

[Term]
id: GO:0003785
name: actin monomer binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with monomeric actin, also known as G-actin." [GOC:ai]
synonym: "G actin binding" EXACT []
is_a: GO:0003779 ! actin binding

[Term]
id: GO:0003786
name: actin lateral binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an actin filament along its length." [GOC:mah]
is_a: GO:0051015 ! actin filament binding

[Term]
id: GO:0003787
name: actin depolymerizing activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
is_obsolete: true
replaced_by: GO:0030042

[Term]
id: GO:0003788
name: actin monomer sequestering activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because sequestering is a process, not an activity.
is_obsolete: true
replaced_by: GO:0042989

[Term]
id: GO:0003789
name: actin filament severing activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a biological process.
is_obsolete: true
replaced_by: GO:0051014

[Term]
id: GO:0003790
name: actin modulating activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not make sense.
is_obsolete: true
consider: GO:0030036

[Term]
id: GO:0003791
name: membrane associated actin binding
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
is_obsolete: true
consider: GO:0003779
consider: GO:0016020

[Term]
id: GO:0003792
name: regulation of actin thin filament length activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the term belongs in the process ontology.
is_obsolete: true
replaced_by: GO:0030832

[Term]
id: GO:0003793
name: defense/immunity protein activity
namespace: molecular_function
def: "OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease." [GOC:go_curators]
comment: This term was made obsolete because it refers to involvement in a biological process.
synonym: "defence/immunity protein activity" EXACT []
is_obsolete: true
consider: GO:0006952

[Term]
id: GO:0003794
name: acute-phase response protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to involvement in a biological process.
is_obsolete: true
consider: GO:0006953

[Term]
id: GO:0003795
name: antimicrobial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, microbial cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
is_obsolete: true
consider: GO:0006952

[Term]
id: GO:0003796
name: lysozyme activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of the prokaryotes cell walls and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17]
subset: gosubset_prok
synonym: "1,4-N-acetylmuramidase activity" EXACT []
synonym: "globulin G" RELATED [EC:3.2.1.17]
synonym: "globulin G1" RELATED [EC:3.2.1.17]
synonym: "L-7001" RELATED [EC:3.2.1.17]
synonym: "lysozyme g" RELATED [EC:3.2.1.17]
synonym: "mucopeptide glucohydrolase activity" EXACT []
synonym: "mucopeptide N-acetylmuramoylhydrolase activity" EXACT []
synonym: "muramidase activity" EXACT []
synonym: "N,O-diacetylmuramidase activity" EXACT []
synonym: "peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [EC:3.2.1.17]
synonym: "PR1-lysozyme" RELATED [EC:3.2.1.17]
xref: EC:3.2.1.17
xref: MetaCyc:3.2.1.17-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0003797
name: antibacterial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
is_obsolete: true
consider: GO:0042742

[Term]
id: GO:0003798
name: male-specific antibacterial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
is_obsolete: true
consider: GO:0050831

[Term]
id: GO:0003799
name: antifungal peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, fungal cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
is_obsolete: true
consider: GO:0050832

[Term]
id: GO:0003800
name: antiviral response protein activity
namespace: molecular_function
def: "OBSOLETE. A protein involved in an antiviral response." [GOC:ai]
comment: This term was made obsolete because it refers to involvement in a biological process.
is_obsolete: true
consider: GO:0009615

[Term]
id: GO:0003801
name: blood coagulation factor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to involvement in a biological process.
is_obsolete: true
consider: GO:0004252
consider: GO:0007596

[Term]
id: GO:0003802
name: coagulation factor VIIa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta." [EC:3.4.21.21, PMID:12496253]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood coagulation factor VII" RELATED [EC:3.4.21.21]
synonym: "blood coagulation factor VII activity" EXACT []
synonym: "blood-coagulation factor VIIa" RELATED [EC:3.4.21.21]
xref: EC:3.4.21.21
xref: MetaCyc:3.4.21.21-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003803
name: coagulation factor IXa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa." [EC:3.4.21.22]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood coagulation factor XI" RELATED [EC:3.4.21.22]
synonym: "activated blood-coagulation factor IX" RELATED [EC:3.4.21.22]
synonym: "activated christmas factor" RELATED [EC:3.4.21.22]
synonym: "autoprothrombin II" RELATED [EC:3.4.21.22]
synonym: "blood coagulation factor IX activity" EXACT []
synonym: "blood platelet cofactor II" RELATED [EC:3.4.21.22]
synonym: "blood-coagulation factor IXa" RELATED [EC:3.4.21.22]
synonym: "Christmas factor activity" EXACT [EC:3.4.21.22]
xref: EC:3.4.21.22
xref: MetaCyc:3.4.21.22-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003804
name: coagulation factor Xa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa)." [EC:3.4.21.6, GOC:jl, PMID:7354023]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood-coagulation factor X" RELATED [EC:3.4.21.6]
synonym: "activated factor X" RELATED [EC:3.4.21.6]
synonym: "activated Stuart-Prower factor" RELATED [EC:3.4.21.6]
synonym: "autoprothrombin C" RELATED [EC:3.4.21.6]
synonym: "blood coagulation factor X activity" EXACT []
synonym: "factor Xa" RELATED [EC:3.4.21.6]
synonym: "plasma thromboplastin" RELATED [EC:3.4.21.6]
synonym: "prothrombase activity" EXACT [EC:3.4.21.6]
synonym: "prothrombinase activity" EXACT [EC:3.4.21.6]
synonym: "Stuart factor" RELATED [EC:3.4.21.6]
synonym: "Stuart factor activity" EXACT [EC:3.4.21.6]
synonym: "thrombokinase activity" EXACT [EC:3.4.21.6]
synonym: "thromboplastin" RELATED [EC:3.4.21.6]
xref: EC:3.4.21.6
xref: MetaCyc:3.4.21.6-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003805
name: coagulation factor XIa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa." [EC:3.4.21.27]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood-coagulation factor XI" RELATED [EC:3.4.21.27]
synonym: "activated plasma thromboplastin antecedent" RELATED [EC:3.4.21.27]
synonym: "blood coagulation factor XI activity" EXACT []
synonym: "blood-coagulation factor XIa" RELATED [EC:3.4.21.27]
synonym: "plasma thromboplastin antecedent activity" EXACT [EC:3.4.21.27]
xref: EC:3.4.21.27
xref: MetaCyc:3.4.21.27-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003806
name: coagulation factor XIIa activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa." [EC:3.4.21.38]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated beta blood-coagulation factor XII" RELATED [EC:3.4.21.38]
synonym: "blood coagulation factor XII activity" EXACT []
synonym: "blood-coagulation factor XIIabeta" RELATED [EC:3.4.21.38]
synonym: "blood-coagulation factor XIIf" RELATED [EC:3.4.21.38]
synonym: "hageman factor (activated)" RELATED [EC:3.4.21.38]
synonym: "hageman factor activity" EXACT [EC:3.4.21.38]
synonym: "hageman factor beta-fragment" RELATED [EC:3.4.21.38]
synonym: "hageman factor fragment HFf" RELATED [EC:3.4.21.38]
synonym: "kallikreinogen activator" RELATED [EC:3.4.21.38]
synonym: "prealbumin activator" RELATED [EC:3.4.21.38]
synonym: "prekallikrein activator" RELATED [EC:3.4.21.38]
xref: EC:3.4.21.38
xref: MetaCyc:3.4.21.38-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003807
name: plasma kallikrein activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin." [EC:3.4.21.34]
comment: This term was made obsolete because it represents a gene product.
synonym: "bradykininogenase" BROAD [EC:3.4.21.34]
synonym: "callicrein" RELATED [EC:3.4.21.34]
synonym: "depot-padutin" RELATED [EC:3.4.21.34]
synonym: "dilminal D" RELATED [EC:3.4.21.34]
synonym: "glumorin" RELATED [EC:3.4.21.34]
synonym: "kallidinogenase" BROAD [EC:3.4.21.34]
synonym: "kallikrein" RELATED [EC:3.4.21.34]
synonym: "kallikrein I" RELATED [EC:3.4.21.34]
synonym: "kallikrein II" RELATED [EC:3.4.21.34]
synonym: "kininogenase" BROAD [EC:3.4.21.34]
synonym: "kininogenin activity" RELATED [EC:3.4.21.34]
synonym: "onokrein P" RELATED [EC:3.4.21.34]
synonym: "padreatin" RELATED [EC:3.4.21.34]
synonym: "padutin" RELATED [EC:3.4.21.34]
synonym: "panceatic kallikrein" RELATED [EC:3.4.21.34]
synonym: "serum kallikrein activity" EXACT [EC:3.4.21.34]
synonym: "urinary kallikrein" RELATED [EC:3.4.21.34]
synonym: "urokallikrein" RELATED [EC:3.4.21.34]
xref: EC:3.4.21.34
xref: MetaCyc:3.4.21.34-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003808
name: protein C (activated) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa." [EC:3.4.21.69]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood coagulation factor XIV activity" EXACT [EC:3.4.21.69]
synonym: "activated protein C" RELATED [EC:3.4.21.69]
synonym: "autoprothrombin II-A" RELATED [EC:3.4.21.69]
synonym: "autoprothrombin IIA activity" EXACT [EC:3.4.21.69]
synonym: "blood-coagulation factor XIVa" RELATED [EC:3.4.21.69]
synonym: "GSAPC" RELATED [EC:3.4.21.69]
synonym: "protein Ca" RELATED [EC:3.4.21.69]
xref: EC:3.4.21.69
xref: MetaCyc:3.4.21.69-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003809
name: thrombin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B." [EC:3.4.21.5]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated blood-coagulation factor II" RELATED [EC:3.4.21.5]
synonym: "beta-thrombin" RELATED [EC:3.4.21.5]
synonym: "blood-coagulation factor IIa" RELATED [EC:3.4.21.5]
synonym: "E thrombin" RELATED [EC:3.4.21.5]
synonym: "factor IIa" RELATED [EC:3.4.21.5]
synonym: "fibrinogenase activity" EXACT [EC:3.4.21.5]
synonym: "gamma-thrombin" RELATED [EC:3.4.21.5]
synonym: "thrombase activity" EXACT [EC:3.4.21.5]
synonym: "thrombin-C" RELATED [EC:3.4.21.5]
synonym: "thrombofort" RELATED [EC:3.4.21.5]
synonym: "topical" RELATED [EC:3.4.21.5]
synonym: "tropostasin" RELATED [EC:3.4.21.5]
xref: EC:3.4.21.5
xref: MetaCyc:3.4.21.5-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003810
name: protein-glutamine gamma-glutamyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124]
subset: gosubset_prok
synonym: "factor XIIIa" RELATED [EC:2.3.2.13]
synonym: "fibrin stabilizing factor" RELATED [EC:2.3.2.13]
synonym: "fibrinoligase activity" EXACT []
synonym: "glutaminylpeptide gamma-glutamyltransferase activity" EXACT [EC:2.3.2.13]
synonym: "polyamine transglutaminase activity" RELATED [EC:2.3.2.13]
synonym: "protein-glutamine:amine gamma-glutamyltransferase" EXACT [EC:2.3.2.13]
synonym: "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity" EXACT [EC:2.3.2.13]
synonym: "TGase activity" EXACT []
synonym: "tissue transglutaminase" NARROW [EC:2.3.2.13]
synonym: "transglutaminase activity" EXACT []
xref: EC:2.3.2.13
xref: MetaCyc:2.3.2.13-RXN
xref: Reactome:11549 "protein-glutamine gamma-glutamyltransferase activity"
xref: RESID:AA0124
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0003811
name: complement activity
namespace: molecular_function
def: "OBSOLETE. Any of a set of activities involved in the complement cascade." [GOC:jl]
comment: This term was made obsolete because it refers to involvement in a biological process.
is_obsolete: true
consider: GO:0006956

[Term]
id: GO:0003812
name: alternative-complement-pathway C3/C5 convertase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b." [EC:3.4.21.47]
comment: This term was made obsolete because it represents a gene product.
synonym: "(C3b)n,Bb" RELATED [EC:3.4.21.47]
synonym: "(CVF)-dependent glycine-rich-beta-glucoprotein" RELATED [EC:3.4.21.47]
synonym: "alternative complement pathway C3(C5) convertase activity" EXACT [EC:3.4.21.47]
synonym: "C3 convertase activity" BROAD [EC:3.4.21.47]
synonym: "C3 proactivator" RELATED [EC:3.4.21.47]
synonym: "C3b,Bb,CVF,Bb,C5 convertase activity" EXACT [EC:3.4.21.47]
synonym: "C5 convertase activity" BROAD [EC:3.4.21.47]
synonym: "cobra venom factor-dependent C3 convertase" NARROW [EC:3.4.21.47]
synonym: "complement C 3(C 5) convertase (amplification)" EXACT [EC:3.4.21.47]
synonym: "complement component C3/C5 convertase (alternative) activity" EXACT [EC:3.4.21.47]
synonym: "complement factor B activity" EXACT [EC:3.4.21.47]
synonym: "CVF,Bb" RELATED [EC:3.4.21.47]
synonym: "glycine-rich beta-glycoprotein" RELATED [EC:3.4.21.47]
synonym: "heat-labile factor" RELATED [EC:3.4.21.47]
synonym: "proenzyme factor B" EXACT []
synonym: "properdin factor B activity" EXACT [EC:3.4.21.47]
xref: EC:3.4.21.47
xref: MetaCyc:3.4.21.47-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003813
name: classical-complement-pathway C3/C5 convertase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b." [EC:3.4.21.43]
comment: This term was made obsolete because it represents a gene product.
synonym: "C3 convertase activity" BROAD [EC:3.4.21.43]
synonym: "C42" RELATED [EC:3.4.21.43]
synonym: "C423" RELATED [EC:3.4.21.43]
synonym: "C4b,2a" RELATED [EC:3.4.21.43]
synonym: "C4b,2a,3b" RELATED [EC:3.4.21.43]
synonym: "C5 convertase activity" BROAD [EC:3.4.21.43]
synonym: "complement C2 activity" BROAD [EC:3.4.21.43]
synonym: "complement C3 convertase activity" EXACT [EC:3.4.21.43]
synonym: "complement C42" RELATED [EC:3.4.21.43]
xref: EC:3.4.21.43
xref: MetaCyc:3.4.21.43-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003815
name: complement component C1r activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42)." [EC:3.4.21.41]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated complement C1r" RELATED [EC:3.4.21.41]
synonym: "C1r esterase activity" EXACT [EC:3.4.21.41]
synonym: "complement subcomponent C1r" RELATED [EC:3.4.21.41]
xref: EC:3.4.21.41
xref: MetaCyc:3.4.21.41-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003816
name: complement component C1s activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond)." [EC:3.4.21.42]
comment: This term was made obsolete because it represents a gene product.
synonym: "activated complement C1s" RELATED [EC:3.4.21.42]
synonym: "C1 esterase activity" EXACT [EC:3.4.21.42]
synonym: "C1s esterase activity" EXACT [EC:3.4.21.42]
synonym: "complement C1s" RELATED [EC:3.4.21.42]
synonym: "complement subcomponent C1s" RELATED [EC:3.4.21.42]
xref: EC:3.4.21.42
xref: MetaCyc:3.4.21.42-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003817
name: complement factor D activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF)." [EC:3.4.21.46]
comment: This term was made obsolete because it represents a gene product.
synonym: "adipsin" EXACT []
synonym: "C3 convertase activator activity" EXACT [EC:3.4.21.46]
synonym: "C3 proactivator convertase activity" EXACT [EC:3.4.21.46]
synonym: "factor D" RELATED [EC:3.4.21.46]
synonym: "factor D (complement)" RELATED [EC:3.4.21.46]
synonym: "properdin factor D esterase activity" EXACT [EC:3.4.21.46]
xref: EC:3.4.21.46
xref: MetaCyc:3.4.21.46-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003818
name: complement factor I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage." [EC:3.4.21.45]
comment: This term was made obsolete because it represents a gene product.
synonym: "C3b inactivator activity" NARROW [EC:3.4.21.45]
synonym: "C3b/C4b inactivator activity" EXACT [EC:3.4.21.45]
synonym: "C3bINA" RELATED [EC:3.4.21.45]
synonym: "complement C3b inactivator" RELATED [EC:3.4.21.45]
synonym: "complement C3b/C4b inactivator" RELATED [EC:3.4.21.45]
synonym: "complement C4b inactivator" RELATED [EC:3.4.21.45]
synonym: "complement C4bi" RELATED [EC:3.4.21.45]
synonym: "complement component C3b inactivator activity" EXACT [EC:3.4.21.45]
synonym: "conglutinogen-activating factor C" RELATED [EC:3.4.21.45]
synonym: "factor I" RELATED [EC:3.4.21.45]
xref: EC:3.4.21.45
xref: MetaCyc:3.4.21.45-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0003819
name: major histocompatibility complex antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "MHC protein" EXACT []
is_obsolete: true

[Term]
id: GO:0003820
name: class I major histocompatibility complex antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
is_obsolete: true
consider: GO:0042612

[Term]
id: GO:0003821
name: class II major histocompatibility complex antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
is_obsolete: true
consider: GO:0042613

[Term]
id: GO:0003822
name: MHC-interacting protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true

[Term]
id: GO:0003823
name: antigen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: goslim_pir
synonym: "antibody" RELATED []
synonym: "B cell receptor activity" RELATED []
synonym: "immunoglobulin" RELATED []
synonym: "opsonin activity" RELATED []
is_a: GO:0005488 ! binding

[Term]
id: GO:0003824
name: catalytic activity
namespace: molecular_function
def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb]
xref: Wikipedia:Enzyme
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0003825
name: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate." [EC:2.4.1.15]
subset: gosubset_prok
synonym: "alpha,alpha-trehalose phosphate synthase (UDP-forming)" EXACT [EC:2.4.1.15]
synonym: "phosphotrehalose-uridine diphosphate transglucosylase activity" EXACT [EC:2.4.1.15]
synonym: "transglucosylase activity" EXACT []
synonym: "trehalose 6-phosphate synthase activity" EXACT []
synonym: "trehalose 6-phosphate synthetase activity" EXACT []
synonym: "trehalose phosphate synthase activity" EXACT [EC:2.4.1.15]
synonym: "trehalose phosphate synthetase activity" EXACT [EC:2.4.1.15]
synonym: "trehalose phosphate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.15]
synonym: "trehalose-P synthetase activity" EXACT [EC:2.4.1.15]
synonym: "trehalose-phosphate synthase activity" EXACT []
synonym: "trehalose-phosphate synthetase activity" EXACT []
synonym: "trehalosephosphate-UDP glucosyl transferase activity" EXACT []
synonym: "trehalosephosphate-UDP glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-glucose-phosphate glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-glucosephosphate glucosyltransferase activity" EXACT [EC:2.4.1.15]
synonym: "UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT []
synonym: "UDPglucose-glucose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15]
synonym: "UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.15]
synonym: "uridine diphosphoglucose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15]
xref: EC:2.4.1.15
xref: MetaCyc:TREHALOSE6PSYN-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0003826
name: alpha-ketoacid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction involving an alpha-ketoacid." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0003827
name: alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2 = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2." [EC:2.4.1.101]
synonym: "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101]
synonym: "alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101]
synonym: "alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "GnTI" RELATED [EC:2.4.1.101]
synonym: "GNTI activity" EXACT [EC:2.4.1.101]
synonym: "N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101]
synonym: "UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.101]
synonym: "UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101]
synonym: "UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101]
synonym: "uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101]
xref: EC:2.4.1.101
xref: MetaCyc:2.4.1.101-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0003828
name: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R." [EC:2.4.99.8]
synonym: "alpha-2,8-sialyltransferase activity" EXACT [EC:2.4.99.8]
synonym: "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity" EXACT []
synonym: "CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.8]
synonym: "CMP-NeuAc:LM1(alpha2-8) sialyltranferase activity" EXACT [EC:2.4.99.8]
synonym: "cytidine monophosphoacetylneuraminate-ganglioside GM3" RELATED [EC:2.4.99.8]
synonym: "ganglioside GD3 synthase activity" EXACT [EC:2.4.99.8]
synonym: "ganglioside GD3 synthetase sialyltransferase activity" EXACT [EC:2.4.99.8]
synonym: "GD3 synthase activity" EXACT [EC:2.4.99.8]
synonym: "SAT-2" RELATED [EC:2.4.99.8]
xref: EC:2.4.99.8
xref: MetaCyc:2.4.99.8-RXN
xref: Reactome:11580 "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0003829
name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R." [EC:2.4.1.102]
synonym: "beta(6)-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102]
synonym: "beta6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102]
synonym: "core 2 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102]
synonym: "core 6-beta-GlcNAc-transferase A" RELATED [EC:2.4.1.102]
synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.102]
synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.102]
synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102]
xref: EC:2.4.1.102
xref: MetaCyc:2.4.1.102-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0003830
name: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144]
subset: gosubset_prok
synonym: "beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144]
synonym: "beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144]
synonym: "GnTIII activity" EXACT [EC:2.4.1.144]
synonym: "N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.144]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III" RELATED [EC:2.4.1.144]
xref: EC:2.4.1.144
xref: MetaCyc:2.4.1.144-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0003831
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide." [EC:2.4.1.38]
synonym: "beta-N-acetyl-beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "GalT activity" RELATED [EC:2.4.1.38]
synonym: "glycoprotein 4-beta-galactosyl-transferase activity" EXACT [EC:2.4.1.38]
synonym: "glycoprotein 4-beta-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "glycoprotein beta-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "thyroid galactosyltransferase activity" NARROW [EC:2.4.1.38]
synonym: "thyroid glycoprotein beta-galactosyltransferase" NARROW [EC:2.4.1.38]
synonym: "UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "UDP-galactose--glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "UDPgalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38]
synonym: "uridine diphosphogalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38]
xref: EC:2.4.1.38
xref: MetaCyc:2.4.1.38-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0003832
name: beta-alanyl-dopamine hydrolase activity
namespace: molecular_function
def: "Catalysis of the conversion of beta-alanyl dopamine to dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:12957543]
synonym: "N-beta-alanyl-dopamine hydrolase activity" EXACT []
synonym: "NBAD hydrolase activity" EXACT []
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0003833
name: beta-alanyl-dopamine synthase activity
namespace: molecular_function
def: "Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:12957543]
synonym: "N-beta-alanyl dopamine synthetase activity" EXACT []
synonym: "NBAD transferase activity" EXACT []
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0003834
name: beta-carotene 15,15'-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-carotene + O2 = 2 retinal." [EC:1.14.99.36]
comment: Note that this function was formerly EC:1.13.11.21.
synonym: "beta-carotene 15,15'-dioxygenase activity" EXACT []
synonym: "beta-carotene:oxygen 15,15'-oxidoreductase (bond-cleaving)" EXACT [EC:1.14.99.36]
synonym: "carotene 15,15'-dioxygenase activity" EXACT [EC:1.14.99.36]
synonym: "carotene dioxygenase activity" EXACT [EC:1.14.99.36]
xref: EC:1.14.99.36
xref: MetaCyc:BETA-CAROTENE-1515-DIOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0003835
name: beta-galactoside alpha-2,6-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine." [EC:2.4.99.1]
synonym: "beta-galactosamide alpha-2,6-sialyltransferase activity" EXACT []
synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.1]
synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.1]
xref: EC:2.4.99.1
xref: MetaCyc:2.4.99.1-RXN
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0003836
name: beta-galactoside alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R." [EC:2.4.99.4]
synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.4]
synonym: "CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity" EXACT [EC:2.4.99.4]
xref: EC:2.4.99.4
xref: MetaCyc:2.4.99.4-RXN
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0003837
name: beta-ureidopropionase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6]
subset: gosubset_prok
synonym: "N-carbamoyl-beta-alanine amidohydrolase activity" EXACT [EC:3.5.1.6]
xref: EC:3.5.1.6
xref: MetaCyc:BETA-UREIDOPROPIONASE-RXN
xref: Reactome:11609 "beta-ureidopropionase activity"
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0003838
name: sterol 24-C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol." [EC:2.1.1.41]
subset: gosubset_prok
synonym: "24-sterol C-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "delta(24)-sterol C-methyltransferase activity" EXACT []
synonym: "delta(24)-sterol methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "delta24-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "delta24-sterol methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "phytosterol methyltransferase activity" NARROW [EC:2.1.1.41]
synonym: "S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "S-adenosyl-4-methionine:sterol delta24-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity" EXACT [EC:2.1.1.41]
synonym: "SMT1 activity" NARROW [EC:2.1.1.41]
synonym: "zymosterol-24-methyltransferase activity" NARROW [EC:2.1.1.41]
xref: EC:2.1.1.41
xref: MetaCyc:RXN3O-178
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0003839
name: gamma-glutamylcyclotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [EC:2.3.2.4]
synonym: "(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.4]
synonym: "gamma-glutamyl-amino acid cyclotransferase activity" EXACT [EC:2.3.2.4]
synonym: "gamma-L-glutamylcyclotransferase activity" EXACT [EC:2.3.2.4]
synonym: "L-glutamic cyclase activity" EXACT [EC:2.3.2.4]
xref: EC:2.3.2.4
xref: MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0003840
name: gamma-glutamyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2]
subset: gosubset_prok
synonym: "(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity" EXACT [EC:2.3.2.2]
synonym: "alpha-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2]
synonym: "gamma-glutamyl peptidyltransferase activity" EXACT [EC:2.3.2.2]
synonym: "gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2]
synonym: "gamma-GPT" RELATED [EC:2.3.2.2]
synonym: "gamma-GT" RELATED [EC:2.3.2.2]
synonym: "gamma-GTP" RELATED [EC:2.3.2.2]
synonym: "glutamyl transpeptidase activity" EXACT [EC:2.3.2.2]
synonym: "L-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2]
synonym: "L-gamma-glutamyltransferase activity" EXACT [EC:2.3.2.2]
synonym: "L-glutamyltransferase activity" EXACT [EC:2.3.2.2]
xref: EC:2.3.2.2
xref: MetaCyc:GAMMA-GLUTAMYLTRANSFERASE-RXN
xref: Reactome:11628 "gamma-glutamyltransferase activity"
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0003841
name: 1-acylglycerol-3-phosphate O-acyltransferase activity
namespace: molecular_function
alt_id: GO:0004469
def: "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate." [EC:2.3.1.51]
subset: gosubset_prok
synonym: "1-acyl-sn-glycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "1-acyl-sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "1-acyl-sn-glycerol-3-phosphate acyltransferase activity" EXACT []
synonym: "1-acylglycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "1-acylglycerolphosphate acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "1-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity" EXACT [EC:2.3.1.51]
synonym: "lysophosphatidate acyltransferase activity" EXACT []
synonym: "lysophosphatidic acid-acyltransferase activity" EXACT [EC:2.3.1.51]
xref: EC:2.3.1.51
xref: MetaCyc:RXN-1623
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity

[Term]
id: GO:0003842
name: 1-pyrroline-5-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H+." [EC:1.5.1.12]
subset: gosubset_prok
synonym: "1-pyrroline dehydrogenase" BROAD [EC:1.5.1.12]
synonym: "1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12]
synonym: "delta1-pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12]
synonym: "L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12]
synonym: "pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12]
synonym: "pyrroline-5-carboxylic acid dehydrogenase activity" EXACT [EC:1.5.1.12]
xref: EC:1.5.1.12
xref: MetaCyc:PYRROLINECARBDEHYDROG-RXN
xref: Reactome:11630 "1-pyrroline-5-carboxylate dehydrogenase activity"
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003843
name: 1,3-beta-glucan synthase activity
namespace: molecular_function
alt_id: GO:0009981
def: "Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1)." [EC:2.4.1.34]
synonym: "(1,3)-beta-glucan (callose) synthase activity" EXACT [EC:2.4.1.34]
synonym: "1,3-beta-D-glucan synthase activity" EXACT [EC:2.4.1.34]
synonym: "1,3-beta-D-glucan synthetase activity" EXACT [EC:2.4.1.34]
synonym: "1,3-beta-D-glucan-UDP glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "beta-1,3-glucan synthase activity" EXACT []
synonym: "beta-1,3-glucan synthetase activity" EXACT [EC:2.4.1.34]
synonym: "callose synthase activity" EXACT []
synonym: "callose synthetase activity" EXACT [EC:2.4.1.34]
synonym: "GS-II" RELATED [EC:2.4.1.34]
synonym: "paramylon synthetase" RELATED [EC:2.4.1.34]
synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "UDP-glucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "UDP-glucose:(1,3)beta-glucan synthase activity" EXACT [EC:2.4.1.34]
synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "UDPglucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34]
synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34]
xref: EC:2.4.1.34
xref: MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0003844
name: 1,4-alpha-glucan branching enzyme activity
namespace: molecular_function
def: "Catalysis of the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain." [EC:2.4.1.18]
subset: gosubset_prok
synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity" EXACT []
synonym: "1,4-glucan-6-(1,4-glucano)-transferase activity" EXACT []
synonym: "alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity" EXACT [EC:2.4.1.18]
synonym: "alpha-glucan-branching glycosyltransferase activity" EXACT [EC:2.4.1.18]
synonym: "amylo-(1,4 to 1,6)transglucosidase activity" EXACT [EC:2.4.1.18]
synonym: "amylo-(1,4->1,6)-transglycosylase activity" EXACT [EC:2.4.1.18]
synonym: "amylose isomerase activity" EXACT [EC:2.4.1.18]
synonym: "branching enzyme activity" RELATED [EC:2.4.1.18]
synonym: "branching glycosyltransferase activity" EXACT [EC:2.4.1.18]
synonym: "enzymatic branching factor" RELATED [EC:2.4.1.18]
synonym: "enzyme Q" RELATED [EC:2.4.1.18]
synonym: "glucosan transglycosylase activity" EXACT [EC:2.4.1.18]
synonym: "glycogen branching enzyme activity" EXACT [EC:2.4.1.18]
synonym: "plant branching enzyme" RELATED [EC:2.4.1.18]
synonym: "Q-enzyme" RELATED [EC:2.4.1.18]
synonym: "starch branching enzyme" RELATED [EC:2.4.1.18]
xref: EC:2.4.1.18
xref: MetaCyc:GLYCOGEN-BRANCH-RXN
xref: Reactome:11632 "1,4-alpha-glucan branching enzyme activity"
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0003845
name: 11-beta-hydroxysteroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H+." [EC:1.1.1.146, PMID:15761036]
subset: gosubset_prok
synonym: "11beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.146]
synonym: "11beta-hydroxysteroid dehydrogenase" EXACT [EC:1.1.1.146]
synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146]
synonym: "corticosteroid 11-reductase" RELATED [EC:1.1.1.146]
synonym: "corticosteroid 11beta-dehydrogenase" RELATED [EC:1.1.1.146]
synonym: "dehydrogenase, 11beta-hydroxy steroid" EXACT [EC:1.1.1.146]
xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN
xref: Reactome:11633 "11-beta-hydroxysteroid dehydrogenase activity"
xref: Wikipedia:11beta-hydroxysteroid_dehydrogenase
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003846
name: 2-acylglycerol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol." [EC:2.3.1.22]
synonym: "acyl coenzyme A-monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22]
synonym: "acyl-CoA:2-acylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.22]
synonym: "acylglycerol palmitoyltransferase activity" EXACT [EC:2.3.1.22]
synonym: "monoacylglycerol acyltransferase activity" EXACT [EC:2.3.1.22]
synonym: "monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22]
xref: EC:2.3.1.22
xref: MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity

[Term]
id: GO:0003847
name: 1-alkyl-2-acetylglycerophosphocholine esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47]
subset: gosubset_prok
synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity" EXACT [EC:3.1.1.47]
synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity" EXACT [EC:3.1.1.47]
synonym: "2-acetyl-1-alkylglycerophosphocholine esterase activity" EXACT []
synonym: "alkylacetyl-GPC:acetylhydrolase activity" EXACT [EC:3.1.1.47]
synonym: "LDL-associated phospholipase A(2) activity" RELATED [EC:3.1.1.47]
synonym: "LDL-associated phospholipase A2" RELATED [EC:3.1.1.47]
synonym: "LDL-PLA(2) activity" RELATED [EC:3.1.1.47]
synonym: "LDL-PLA2" RELATED [EC:3.1.1.47]
synonym: "PAF 2-acylhydrolase activity" RELATED [EC:3.1.1.47]
synonym: "PAF acetylhydrolase activity" RELATED [EC:3.1.1.47]
synonym: "platelet-activating factor acetylhydrolase activity" RELATED [EC:3.1.1.47]
xref: EC:3.1.1.47
xref: MetaCyc:3.1.1.47-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0003848
name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine." [EC:2.7.6.3]
subset: gosubset_prok
synonym: "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT []
synonym: "6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "7,8-dihydroxymethylpterin-pyrophosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity" EXACT [EC:2.7.6.3]
synonym: "H2-pteridine-CH2OH pyrophosphokinase activity" EXACT [EC:2.7.6.3]
synonym: "HPPK" RELATED [EC:2.7.6.3]
synonym: "hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [EC:2.7.6.3]
xref: EC:2.7.6.3
xref: MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0003849
name: 3-deoxy-7-phosphoheptulonate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate." [EC:2.5.1.54]
comment: Note that this function was formerly EC:4.1.2.15.
subset: gosubset_prok
synonym: "2-dehydro-3-deoxy-phosphoheptonate aldolase activity" EXACT [EC:2.5.1.54]
synonym: "2-dehydro-3-deoxyphosphoheptonate aldolase activity" EXACT []
synonym: "2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54]
synonym: "3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54]
synonym: "3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54]
synonym: "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity" EXACT [EC:2.5.1.54]
synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate" RELATED [EC:2.5.1.54]
synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54]
synonym: "7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54]
synonym: "D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54]
synonym: "D-erythrose-4-phosphate-lyase activity" RELATED [EC:2.5.1.54]
synonym: "DAH7-P synthase activity" EXACT [EC:2.5.1.54]
synonym: "DAHP synthase activity" EXACT [EC:2.5.1.54]
synonym: "deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54]
synonym: "DHAP synthase activity" EXACT [EC:2.5.1.54]
synonym: "DS-Co activity" RELATED [EC:2.5.1.54]
synonym: "DS-Mn activity" RELATED [EC:2.5.1.54]
synonym: "KDPH synthase activity" EXACT [EC:2.5.1.54]
synonym: "KDPH synthetase activity" EXACT [EC:2.5.1.54]
synonym: "phospho-2-dehydro-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54]
synonym: "phospho-2-keto-3-deoxyheptanoate aldolase activity" EXACT [EC:2.5.1.54]
synonym: "phospho-2-keto-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54]
synonym: "phospho-2-keto-3-deoxyheptonic aldolase activity" EXACT [EC:2.5.1.54]
synonym: "phospho-2-oxo-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54]
synonym: "phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.54]
xref: EC:2.5.1.54
xref: MetaCyc:DAHPSYN-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0003850
name: 2-deoxyglucose-6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate." [EC:3.1.3.68]
synonym: "2-deoxy-D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.68]
synonym: "2-deoxyglucose-6-phosphate phosphatase activity" EXACT [EC:3.1.3.68]
xref: EC:3.1.3.68
xref: MetaCyc:3.1.3.68-RXN
is_a: GO:0019203 ! carbohydrate phosphatase activity

[Term]
id: GO:0003851
name: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45]
synonym: "cerebroside synthase activity" EXACT [EC:2.4.1.45]
synonym: "UDP-galactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45]
synonym: "UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45]
synonym: "UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45]
synonym: "UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45]
synonym: "UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45]
synonym: "UDPgalactose:ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45]
synonym: "uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45]
xref: EC:2.4.1.45
xref: MetaCyc:2.4.1.45-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0003852
name: 2-isopropylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA." [EC:2.3.3.13]
comment: Note that this function was formerly EC:4.1.3.12.
subset: gosubset_prok
synonym: "3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.13]
synonym: "acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.13]
synonym: "alpha-IPM synthetase activity" EXACT [EC:2.3.3.13]
synonym: "alpha-isopropylmalate synthase activity" EXACT [EC:2.3.3.13]
synonym: "alpha-isopropylmalate synthetase activity" EXACT [EC:2.3.3.13]
synonym: "alpha-isopropylmalic synthetase activity" EXACT [EC:2.3.3.13]
synonym: "isopropylmalate synthase activity" EXACT [EC:2.3.3.13]
synonym: "isopropylmalate synthetase activity" EXACT [EC:2.3.3.13]
xref: EC:2.3.3.13
xref: MetaCyc:2-ISOPROPYLMALATESYN-RXN
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0003853
name: 2-methylacyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor." [EC:1.3.99.12]
synonym: "2-methyl branched chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.12]
synonym: "2-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.12]
synonym: "2-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.12]
synonym: "branched-chain acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.12]
xref: EC:1.3.99.12
xref: MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0003854
name: 3-beta-hydroxy-delta5-steroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-beta-hydroxy-delta(5)-steroid + NAD+ = 3-oxo-delta(5)-steroid + NADH + H+." [EC:1.1.1.145]
subset: gosubset_prok
synonym: "3-beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "3-beta-hydroxy-D5-steroid dehydrogenase activity" EXACT []
synonym: "3beta-HSDH" RELATED [EC:1.1.1.145]
synonym: "3beta-hydroxy steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-5-ene-steroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-5-ene-steroid oxidoreductase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-steroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.145]
synonym: "5-ene-3-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "delta5-3beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145]
synonym: "progesterone reductase activity" BROAD [EC:1.1.1.145]
synonym: "steroid-delta5-3beta-ol dehydrogenase activity" EXACT [EC:1.1.1.145]
xref: EC:1.1.1.145
xref: MetaCyc:1.1.1.145-RXN
xref: Reactome:11642 "3-beta-hydroxy-delta5-steroid dehydrogenase activity"
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003855
name: 3-dehydroquinate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O." [EC:4.2.1.10]
subset: gosubset_prok
synonym: "3-dehydroquinase activity" EXACT [EC:4.2.1.10]
synonym: "3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)" EXACT [EC:4.2.1.10]
synonym: "3-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10]
synonym: "3-dehydroquinate hydrolase activity" EXACT [EC:4.2.1.10]
synonym: "5-dehydroquinase activity" EXACT [EC:4.2.1.10]
synonym: "5-dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10]
synonym: "5-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10]
synonym: "dehydroquinase activity" EXACT [EC:4.2.1.10]
synonym: "dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10]
synonym: "DHQase" EXACT [EC:4.2.1.10]
xref: EC:4.2.1.10
xref: MetaCyc:3-DEHYDROQUINATE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0003856
name: 3-dehydroquinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-deoxy-arabino-heptulosonate 7-phosphate = 3-dehydroquinate + phosphate." [EC:4.2.3.4]
subset: gosubset_prok
synonym: "3-dehydroquinate synthetase activity" EXACT [EC:4.2.3.4]
synonym: "3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing)" EXACT [EC:4.2.3.4]
synonym: "3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing; 3-dehydroquinate-forming)" EXACT [EC:4.2.3.4]
synonym: "3-deoxy-arabino-heptulosonate-7-phosphate phosphate-lyase (cyclizing)" EXACT [EC:4.2.3.4]
synonym: "5-dehydroquinate synthase activity" EXACT [EC:4.2.3.4]
synonym: "5-dehydroquinic acid synthetase activity" EXACT [EC:4.2.3.4]
synonym: "dehydroquinate synthase activity" EXACT [EC:4.2.3.4]
xref: EC:4.2.3.4
xref: MetaCyc:3-DEHYDROQUINATE-SYNTHASE-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0003857
name: 3-hydroxyacyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+." [EC:1.1.1.35]
comment: See also 'long-chain-3-hydroxyacyl-CoA dehydrogenase activity ; GO:0016509'.
subset: gosubset_prok
synonym: "beta-hydroxyacyl dehydrogenase activity" EXACT [EC:1.1.1.35]
synonym: "beta-hydroxyacyl-coenzyme A synthetase activity" EXACT [EC:1.1.1.35]
synonym: "beta-hydroxyacylcoenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35]
synonym: "beta-hydroxybutyrylcoenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35]
synonym: "beta-keto-reductase activity" EXACT [EC:1.1.1.35]
synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.35]
synonym: "L-3-hydroxyacyl CoA dehydrogenase activity" EXACT [EC:1.1.1.35]
synonym: "L-3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35]
xref: EC:1.1.1.35
xref: MetaCyc:OHACYL-COA-DEHYDROG-RXN
xref: Reactome:11645 "3-hydroxyacyl-CoA dehydrogenase activity"
xref: UM-BBD_enzymeID:e0664
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003858
name: 3-hydroxybutyrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH + H+." [EC:1.1.1.30]
subset: gosubset_prok
synonym: "D-beta-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.30]
xref: EC:1.1.1.30
xref: MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN
xref: Reactome:11646 "3-hydroxybutyrate dehydrogenase activity"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003859
name: 3-hydroxybutyryl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H2O." [EC:4.2.1.55]
subset: gosubset_prok
synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)" EXACT [EC:4.2.1.55]
synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.55]
synonym: "crotonase activity" EXACT [EC:4.2.1.55]
synonym: "D-3-hydroxybutyryl coenzyme A dehydratase activity" EXACT [EC:4.2.1.55]
synonym: "D-3-hydroxybutyryl-CoA dehydratase activity" EXACT [EC:4.2.1.55]
synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.55]
xref: EC:4.2.1.55
xref: MetaCyc:3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0003860
name: 3-hydroxyisobutyryl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate." [EC:3.1.2.4]
subset: gosubset_prok
synonym: "3-hydroxy-2-methylpropanoyl-CoA hydrolase activity" EXACT [EC:3.1.2.4]
synonym: "3-hydroxy-isobutyryl CoA hydrolase activity" EXACT [EC:3.1.2.4]
synonym: "HIB CoA deacylase activity" EXACT [EC:3.1.2.4]
xref: EC:3.1.2.4
xref: MetaCyc:3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN
xref: Reactome:11660 "3-hydroxyisobutyryl-CoA hydrolase activity"
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0003861
name: 3-isopropylmalate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-isopropylmalate = 2-isopropylmaleate + H2O." [EC:4.2.1.33]
subset: gosubset_prok
synonym: "(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)" EXACT [EC:4.2.1.33]
synonym: "(2R,3S)-3-isopropylmalate hydro-lyase activity" EXACT [EC:4.2.1.33]
synonym: "alpha-IPM isomerase activity" EXACT [EC:4.2.1.33]
synonym: "alpha-isopropylmalate isomerase activity" EXACT [EC:4.2.1.33]
synonym: "beta-isopropylmalate dehydratase activity" EXACT [EC:4.2.1.33]
synonym: "isopropylmalate isomerase activity" EXACT [EC:4.2.1.33]
xref: EC:4.2.1.33
xref: MetaCyc:3-ISOPROPYLMALISOM-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0003862
name: 3-isopropylmalate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+." [EC:1.1.1.85]
subset: gosubset_prok
synonym: "(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85]
synonym: "3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85]
synonym: "beta-IPM dehydrogenase activity" EXACT [EC:1.1.1.85]
synonym: "beta-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85]
synonym: "beta-isopropylmalic enzyme" RELATED [EC:1.1.1.85]
synonym: "IMDH activity" EXACT [EC:1.1.1.85]
synonym: "IPMDH" RELATED [EC:1.1.1.85]
synonym: "threo-Ds-3-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85]
xref: EC:1.1.1.85
xref: MetaCyc:3-ISOPROPYLMALDEHYDROG-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003863
name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2." [EC:1.2.4.4]
subset: gosubset_prok
synonym: "2-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "2-oxoisovalerate (lipoate) dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity" EXACT [EC:1.2.4.4]
synonym: "3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)" EXACT [EC:1.2.4.4]
synonym: "3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity" EXACT [EC:1.2.4.4]
synonym: "alpha-keto-alpha-methylvalerate dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "alpha-ketoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "alpha-ketoisocaproic dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "alpha-ketoisovalerate dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "alpha-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4]
synonym: "BCKDH activity" RELATED [EC:1.2.4.4]
synonym: "BCOAD activity" RELATED [EC:1.2.4.4]
synonym: "branched chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain (-2-oxoacid) dehydrogenase (BCD) activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain 2-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain 2-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain alpha-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain alpha-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "branched-chain ketoacid dehydrogenase activity" RELATED [EC:1.2.4.4]
synonym: "dehydrogenase, 2-oxoisovalerate (lipoate) activity" EXACT [EC:1.2.4.4]
synonym: "dehydrogenase, branched chain alpha-keto acid activity" RELATED [EC:1.2.4.4]
xref: EC:1.2.4.4
xref: MetaCyc:1.2.4.4-RXN
xref: Reactome:11663 "3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity"
is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

[Term]
id: GO:0003864
name: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate." [EC:2.1.2.11]
subset: gosubset_prok
synonym: "5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
synonym: "5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
synonym: "alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
synonym: "dehydropantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
synonym: "ketopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
synonym: "oxopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11]
xref: EC:2.1.2.11
xref: MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0003865
name: 3-oxo-5-alpha-steroid 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor." [EC:1.3.99.5]
synonym: "3-keto-delta4-steroid-5alpha-reductase activity" EXACT [EC:1.3.99.5]
synonym: "3-oxo-5alpha-steroid 4-dehydrogenase activity" EXACT [EC:1.3.99.5]
synonym: "3-oxo-5alpha-steroid delta4-dehydrogenase activity" EXACT [EC:1.3.99.5]
synonym: "3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity" EXACT [EC:1.3.99.5]
synonym: "3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC:1.3.99.5]
synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.99.5]
synonym: "4-ene-3-ketosteroid-5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5]
synonym: "5alpha-reductase" BROAD [EC:1.3.99.5]
synonym: "delta4-3-keto steroid 5alpha-reductase activity" EXACT [EC:1.3.99.5]
synonym: "delta4-3-ketosteroid5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5]
synonym: "delta4-3-oxo steroid reductase activity" EXACT [EC:1.3.99.5]
synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.99.5]
synonym: "delta4-5alpha-dehydrogenase activity" EXACT [EC:1.3.99.5]
synonym: "steroid 5 alpha reductase" BROAD [EC:1.3.99.5]
synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.99.5]
synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.99.5]
synonym: "steroid delta4-5alpha-reductase activity" EXACT [EC:1.3.99.5]
synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.99.5]
xref: EC:1.3.99.5
xref: MetaCyc:1.3.99.5-RXN
is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors

[Term]
id: GO:0003866
name: 3-phosphoshikimate 1-carboxyvinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate." [EC:2.5.1.19]
subset: gosubset_prok
synonym: "3-enol-pyruvoylshikimate-5-phosphate synthase activity" EXACT [EC:2.5.1.19]
synonym: "5-enolpyruvylshikimate-3-phosphate synthase activity" EXACT [EC:2.5.1.19]
synonym: "EPSP synthase activity" EXACT [EC:2.5.1.19]
synonym: "phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity" EXACT [EC:2.5.1.19]
xref: EC:2.5.1.19
xref: MetaCyc:2.5.1.19-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0003867
name: 4-aminobutyrate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [EC:2.6.1.19, GOC:mah]
subset: gosubset_prok
synonym: "4-aminobutanoate transaminase activity" EXACT []
synonym: "4-aminobutyrate aminotransferase activity" EXACT []
synonym: "4-aminobutyric acid aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "aminobutyrate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "aminobutyrate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "beta-alanine aminotransferase" RELATED [EC:2.6.1.19]
synonym: "beta-alanine--oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19]
synonym: "beta-alanine-oxoglutarate transaminase activity" RELATED [EC:2.6.1.19]
synonym: "GABA aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "GABA transaminase activity" EXACT []
synonym: "GABA transferase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-amino-N-butyrate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyrate aminotransaminase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyrate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyric acid aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyric acid transaminase activity" EXACT []
synonym: "gamma-aminobutyric transaminase activity" EXACT [EC:2.6.1.19]
synonym: "glutamate-succinic semialdehyde transaminase activity" EXACT [EC:2.6.1.19]
xref: EC:2.6.1.19
xref: MetaCyc:GABATRANSAM-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0003868
name: 4-hydroxyphenylpyruvate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2." [EC:1.13.11.27]
subset: gosubset_prok
synonym: "4-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27]
synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)" EXACT [EC:1.13.11.27]
synonym: "4-hydroxyphenylpyruvic acid dioxygenase activity" EXACT [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvate dioxygenase activity" EXACT [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvate oxidase activity" EXACT [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvic acid hydroxylase activity" EXACT [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvic hydroxylase activity" EXACT [EC:1.13.11.27]
synonym: "p-hydroxyphenylpyruvic oxidase activity" EXACT [EC:1.13.11.27]
xref: EC:1.13.11.27
xref: MetaCyc:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN
xref: Reactome:11670 "4-hydroxyphenylpyruvate dioxygenase activity"
xref: UM-BBD_enzymeID:e0126
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0003869
name: 4-nitrophenylphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate." [EC:3.1.3.41]
subset: gosubset_prok
synonym: "4-nitrophenylphosphate phosphohydrolase activity" EXACT [EC:3.1.3.41]
synonym: "ecto-p-nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41]
synonym: "K-pNPPase activity" EXACT [EC:3.1.3.41]
synonym: "nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41]
synonym: "NPPase activity" EXACT [EC:3.1.3.41]
synonym: "p-nitrophenylphosphatase activity" EXACT [EC:3.1.3.41]
synonym: "p-nitrophenylphosphate phosphohydrolase activity" EXACT [EC:3.1.3.41]
synonym: "para-nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41]
synonym: "PNPPase activity" EXACT [EC:3.1.3.41]
xref: EC:3.1.3.41
xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0003870
name: 5-aminolevulinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2." [EC:2.3.1.37]
subset: gosubset_prok
synonym: "5-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37]
synonym: "5-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37]
synonym: "5-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37]
synonym: "ALA synthase activity" EXACT [EC:2.3.1.37]
synonym: "ALA synthetase activity" EXACT [EC:2.3.1.37]
synonym: "ALAS activity" EXACT [EC:2.3.1.37]
synonym: "alpha-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37]
synonym: "aminolevulinate synthase activity" EXACT [EC:2.3.1.37]
synonym: "aminolevulinate synthetase activity" EXACT [EC:2.3.1.37]
synonym: "aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37]
synonym: "aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37]
synonym: "aminolevulinic synthetase activity" EXACT [EC:2.3.1.37]
synonym: "delta-ALA synthetase activity" EXACT [EC:2.3.1.37]
synonym: "delta-aminolevulinate synthase activity" EXACT [EC:2.3.1.37]
synonym: "delta-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37]
synonym: "delta-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37]
synonym: "delta-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37]
synonym: "delta-aminolevulinic synthetase activity" EXACT [EC:2.3.1.37]
synonym: "succinyl-CoA:glycine C-succinyltransferase (decarboxylating)" EXACT [EC:2.3.1.37]
xref: EC:2.3.1.37
xref: MetaCyc:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN
xref: Reactome:11690 "5-aminolevulinate synthase activity"
is_a: GO:0016749 ! N-succinyltransferase activity

[Term]
id: GO:0003871
name: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine." [EC:2.1.1.14]
subset: gosubset_prok
synonym: "5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.14]
synonym: "cobalamin-independent methionine synthase activity" EXACT [EC:2.1.1.14]
synonym: "homocysteine methylase activity" EXACT [EC:2.1.1.14]
synonym: "MetE" RELATED [EC:2.1.1.14]
synonym: "methionine synthase (cobalamin-independent) activity" EXACT [EC:2.1.1.14]
synonym: "methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity" EXACT [EC:2.1.1.14]
synonym: "methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14]
synonym: "tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14]
synonym: "tetrahydropteroyltriglutamate methyltransferase activity" EXACT [EC:2.1.1.14]
xref: EC:2.1.1.14
xref: MetaCyc:HOMOCYSMET-RXN
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0042085 ! 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity

[Term]
id: GO:0003872
name: 6-phosphofructokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.11]
subset: gosubset_prok
synonym: "6-phosphofructokinase reduction" EXACT []
synonym: "6-phosphofructose 1-kinase activity" EXACT [EC:2.7.1.11]
synonym: "ATP-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11]
synonym: "ATP:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11]
synonym: "D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11]
synonym: "fructose 6-phosphate kinase activity" EXACT [EC:2.7.1.11]
synonym: "fructose 6-phosphokinase activity" EXACT [EC:2.7.1.11]
synonym: "nucleotide triphosphate-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11]
synonym: "PFK" RELATED [EC:2.7.1.11]
synonym: "phospho-1,6-fructokinase activity" EXACT [EC:2.7.1.11]
synonym: "phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.11]
synonym: "phosphofructokinase I activity" EXACT [EC:2.7.1.11]
synonym: "phosphohexokinase activity" BROAD [EC:2.7.1.11]
xref: EC:2.7.1.11
xref: MetaCyc:6PFRUCTPHOS-RXN
xref: Reactome:11692 "6-phosphofructokinase activity"
is_a: GO:0008443 ! phosphofructokinase activity

[Term]
id: GO:0003873
name: 6-phosphofructo-2-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 2,6-bisphosphate." [EC:2.7.1.105]
synonym: "6-phosphofructo-2-kinase (phosphorylating)" EXACT [EC:2.7.1.105]
synonym: "6-phosphofructose 2-kinase activity" EXACT [EC:2.7.1.105]
synonym: "ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105]
synonym: "ATP:D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105]
synonym: "fructose 6-phosphate 2-kinase activity" EXACT [EC:2.7.1.105]
synonym: "phosphofructokinase 2 activity" EXACT [EC:2.7.1.105]
xref: EC:2.7.1.105
xref: MetaCyc:6-PHOSPHOFRUCTO-2-KINASE-RXN
xref: Reactome:11695 "6-phosphofructo-2-kinase activity"
is_a: GO:0008443 ! phosphofructokinase activity

[Term]
id: GO:0003874
name: 6-pyruvoyltetrahydropterin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate." [EC:4.2.3.12]
subset: gosubset_prok
synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity" EXACT [EC:4.2.3.12]
synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)" EXACT [EC:4.2.3.12]
synonym: "6-pyruvoyl tetrahydrobiopterin synthase activity" EXACT [EC:4.2.3.12]
synonym: "PTPS activity" EXACT [EC:4.2.3.12]
xref: EC:4.2.3.12
xref: MetaCyc:4.2.3.12-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0003875
name: ADP-ribosylarginine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose." [EC:3.2.2.19]
subset: gosubset_prok
synonym: "ADP-ribose-L-arginine cleavage enzyme activity" EXACT [EC:3.2.2.19]
synonym: "ADP-ribose-L-arginine cleaving enzyme activity" EXACT [EC:3.2.2.19]
synonym: "ADPribosylarginine hydrolase activity" EXACT []
synonym: "N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19]
synonym: "nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19]
synonym: "omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19]
synonym: "protein ADP-ribosylarginine hydrolase activity" EXACT [EC:3.2.2.19]
synonym: "protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19]
xref: EC:3.2.2.19
xref: MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0003876
name: AMP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + H2O = IMP + NH3." [EC:3.5.4.6]
synonym: "5-adenylate deaminase activity" EXACT [EC:3.5.4.6]
synonym: "5-adenylic acid deaminase activity" EXACT [EC:3.5.4.6]
synonym: "5-AMP deaminase activity" EXACT [EC:3.5.4.6]
synonym: "adenosine 5-monophosphate deaminase activity" EXACT [EC:3.5.4.6]
synonym: "adenosine 5-phosphate aminohydrolase activity" EXACT [EC:3.5.4.6]
synonym: "adenosine monophosphate deaminase activity" EXACT [EC:3.5.4.6]
synonym: "adenyl deaminase activity" EXACT [EC:3.5.4.6]
synonym: "adenylate aminohydrolase activity" EXACT [EC:3.5.4.6]
synonym: "adenylate deaminase activity" EXACT [EC:3.5.4.6]
synonym: "adenylate deaminase reaction" EXACT []
synonym: "adenylate desaminase activity" EXACT [EC:3.5.4.6]
synonym: "adenylic acid deaminase activity" EXACT [EC:3.5.4.6]
synonym: "adenylic deaminase activity" EXACT [EC:3.5.4.6]
synonym: "AMP aminase activity" EXACT [EC:3.5.4.6]
synonym: "AMP aminohydrolase activity" EXACT [EC:3.5.4.6]
synonym: "myoadenylate deaminase activity" NARROW [EC:3.5.4.6]
xref: EC:3.5.4.6
xref: MetaCyc:AMP-DEAMINASE-RXN
xref: Reactome:11698 "AMP deaminase activity"
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0003877
name: ATP adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate." [EC:2.7.7.53]
subset: gosubset_prok
synonym: "adenine triphosphate adenylyltransferase activity" EXACT [EC:2.7.7.53]
synonym: "ADP:ATP adenylyltransferase activity" EXACT []
synonym: "AP-4-A phosphorylase activity" EXACT [EC:2.7.7.53]
synonym: "bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity" EXACT [EC:2.7.7.53]
synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)" EXACT [EC:2.7.7.53]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53]
synonym: "diadenosinetetraphosphate alpha-beta-phosphorylase activity" EXACT [EC:2.7.7.53]
synonym: "diadenosinetetraphosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53]
synonym: "dinucleoside oligophosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53]
xref: EC:2.7.7.53
xref: MetaCyc:ATP-ADENYLYLTRANSFERASE-RXN
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0003878
name: ATP citrate synthase activity
namespace: molecular_function
alt_id: GO:0046913
def: "Catalysis of the reaction: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA." [EC:2.3.3.8]
comment: Note that this function was formerly EC:4.1.3.8.
synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [EC:2.3.3.8]
synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [EC:2.3.3.8]
synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [EC:2.3.3.8]
synonym: "adenosine triphosphate citrate lyase activity" EXACT [EC:2.3.3.8]
synonym: "ATP citrate (pro-S)-lyase activity" EXACT [EC:2.3.3.8]
synonym: "ATP-citrate (pro-S)-lyase activity" EXACT []
synonym: "ATP-citrate (pro-S-)-lyase activity" EXACT [EC:2.3.3.8]
synonym: "ATP-citric lyase activity" EXACT [EC:2.3.3.8]
synonym: "ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [EC:2.3.3.8]
synonym: "ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [EC:2.3.3.8]
synonym: "citrate cleavage enzyme activity" RELATED [EC:2.3.3.8]
synonym: "citrate-ATP lyase activity" EXACT [EC:2.3.3.8]
synonym: "citric cleavage enzyme activity" RELATED [EC:2.3.3.8]
xref: EC:2.3.3.8
xref: MetaCyc:ATP-CITRATE-PRO-S--LYASE-RXN
xref: MetaCyc:PWY-5172
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0003879
name: ATP phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.17]
subset: gosubset_prok
synonym: "1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.17]
synonym: "adenosine triphosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17]
synonym: "phosphoribosyl ATP synthetase activity" EXACT [EC:2.4.2.17]
synonym: "phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17]
synonym: "phosphoribosyl-ATP diphosphorylase activity" EXACT [EC:2.4.2.17]
synonym: "phosphoribosyl-ATP pyrophosphorylase activity" EXACT [EC:2.4.2.17]
synonym: "phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity" EXACT [EC:2.4.2.17]
synonym: "phosphoribosyladenosine triphosphate pyrophosphorylase activity" EXACT [EC:2.4.2.17]
synonym: "phosphoribosyladenosine triphosphate synthetase activity" EXACT [EC:2.4.2.17]
synonym: "phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17]
xref: EC:2.4.2.17
xref: MetaCyc:ATPPHOSPHORIBOSYLTRANS-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0003880
name: C-terminal protein carboxyl methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the carbon atom of the C-terminal residue of a protein." [PMID:8428937]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008276 ! protein methyltransferase activity

[Term]
id: GO:0003881
name: CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol." [EC:2.7.8.11]
subset: gosubset_prok
synonym: "CDP diglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11]
synonym: "CDP-DG:inositol transferase activity" EXACT [EC:2.7.8.11]
synonym: "CDP-diacylglycerol--inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11]
synonym: "CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11]
synonym: "CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11]
synonym: "CDP-diglyceride-inositol transferase activity" EXACT [EC:2.7.8.11]
synonym: "CDP-diglyceride:inositol transferase activity" EXACT [EC:2.7.8.11]
synonym: "CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11]
synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11]
synonym: "cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11]
synonym: "cytidine diphosphoglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11]
synonym: "cytidine diphosphoglyceride-inositol transferase activity" EXACT [EC:2.7.8.11]
synonym: "phosphatidylinositol synthase activity" EXACT []
xref: EC:2.7.8.11
xref: MetaCyc:2.7.8.11-RXN
is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity

[Term]
id: GO:0003882
name: CDP-diacylglycerol-serine O-phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine." [EC:2.7.8.8]
subset: gosubset_prok
synonym: "CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8]
synonym: "phosphatidylserine synthase activity" EXACT [EC:2.7.8.8]
synonym: "phosphatidylserine synthetase activity" EXACT [EC:2.7.8.8]
synonym: "PS synthase activity" EXACT [EC:2.7.8.8]
synonym: "serine exchange enzyme" BROAD []
xref: EC:2.7.8.8
xref: MetaCyc:PHOSPHASERSYN-RXN
is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity

[Term]
id: GO:0003883
name: CTP synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP." [EC:6.3.4.2]
subset: gosubset_prok
synonym: "CTP synthetase activity" EXACT [EC:6.3.4.2]
synonym: "cytidine 5'-triphosphate synthetase activity" EXACT [EC:6.3.4.2]
synonym: "cytidine triphosphate synthetase activity" EXACT [EC:6.3.4.2]
synonym: "uridine triphosphate aminase activity" EXACT [EC:6.3.4.2]
synonym: "UTP--ammonia ligase activity" EXACT [EC:6.3.4.2]
synonym: "UTP:ammonia ligase (ADP-forming)" EXACT [EC:6.3.4.2]
xref: EC:6.3.4.2
xref: MetaCyc:CTPSYN-RXN
xref: Reactome:11718 "CTP synthase activity"
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0003884
name: D-amino-acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2." [EC:1.4.3.3]
subset: gosubset_prok
synonym: "D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.3]
synonym: "L-amino acid:O2 oxidoreductase activity" EXACT [EC:1.4.3.3]
synonym: "new yellow enzyme" RELATED [EC:1.4.3.3]
xref: EC:1.4.3.3
xref: MetaCyc:D-AMINO-ACID-OXIDASE-RXN
xref: Reactome:11719 "D-amino-acid oxidase activity"
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0003885
name: D-arabinono-1,4-lactone oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2." [EC:1.1.3.37]
subset: gosubset_prok
synonym: "D-arabinono-1,4-lactone:oxygen oxidoreductase activity" EXACT [EC:1.1.3.37]
xref: EC:1.1.3.37
xref: MetaCyc:1.1.3.37-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0003886
name: DNA (cytosine-5-)-methyltransferase activity
namespace: molecular_function
alt_id: GO:0008326
def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37]
comment: Note that EC:2.1.1.73 was deleted from EC as the reaction is performed by DNA (cytosine-5-)-methyltransferase (EC:2.1.1.37).
subset: gosubset_prok
synonym: "cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.37]
synonym: "cytosine DNA methylase activity" BROAD [EC:2.1.1.37]
synonym: "cytosine DNA methyltransferase activity" BROAD [EC:2.1.1.37]
synonym: "cytosine-specific DNA methyltransferase activity" EXACT [EC:2.1.1.37]
synonym: "deoxyribonucleic (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37]
synonym: "deoxyribonucleic acid (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37]
synonym: "deoxyribonucleic methylase activity" BROAD [EC:2.1.1.37]
synonym: "DNA 5-cytosine methylase activity" EXACT [EC:2.1.1.37]
synonym: "DNA cytosine C(5) methylase activity" EXACT [EC:2.1.1.37]
synonym: "DNA cytosine c5 methylase activity" EXACT [EC:2.1.1.37]
synonym: "DNA cytosine C5 methylase activity" EXACT [EC:2.1.1.37]
synonym: "DNA cytosine methylase activity" BROAD [EC:2.1.1.37]
synonym: "DNA-cytosine 5-methylase activity" EXACT [EC:2.1.1.37]
synonym: "DNA-cytosine methyltransferase activity" BROAD [EC:2.1.1.37]
synonym: "methylphosphotriester-DNA methyltransferase activity" RELATED [EC:2.1.1.37]
synonym: "modification methylase activity" RELATED [EC:2.1.1.37]
synonym: "restriction-modification system activity" RELATED [EC:2.1.1.37]
synonym: "S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37]
synonym: "site-specific DNA-methyltransferase (cytosine-specific) activity" NARROW [EC:2.1.1.37]
synonym: "type II DNA methylase activity" RELATED [EC:2.1.1.37]
xref: EC:2.1.1.37
xref: MetaCyc:2.1.1.73-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0009008 ! DNA-methyltransferase activity

[Term]
id: GO:0003887
name: DNA-directed DNA polymerase activity
namespace: molecular_function
alt_id: GO:0003888
alt_id: GO:0003889
alt_id: GO:0003890
alt_id: GO:0003891
alt_id: GO:0003893
alt_id: GO:0003894
alt_id: GO:0003895
alt_id: GO:0008723
alt_id: GO:0015999
alt_id: GO:0016000
alt_id: GO:0016448
alt_id: GO:0016449
alt_id: GO:0016450
alt_id: GO:0016451
alt_id: GO:0016452
alt_id: GO:0019984
def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684]
subset: gosubset_prok
synonym: "alpha DNA polymerase activity" NARROW []
synonym: "beta DNA polymerase activity" NARROW []
synonym: "delta DNA polymerase activity" NARROW []
synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7]
synonym: "deoxyribonucleic acid duplicase activity" EXACT [EC:2.7.7.7]
synonym: "deoxyribonucleic duplicase activity" EXACT [EC:2.7.7.7]
synonym: "deoxyribonucleic polymerase I" NARROW [EC:2.7.7.7]
synonym: "DNA duplicase activity" EXACT [EC:2.7.7.7]
synonym: "DNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7]
synonym: "DNA polymerase alpha" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase beta" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase gamma" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase I" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase II" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase III" NARROW [EC:2.7.7.7]
synonym: "DNA polymerase V activity" NARROW []
synonym: "DNA replicase activity" EXACT [EC:2.7.7.7]
synonym: "DNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.7]
synonym: "duplicase" BROAD [EC:2.7.7.7]
synonym: "epsilon DNA polymerase activity" NARROW []
synonym: "eta DNA polymerase activity" NARROW []
synonym: "gamma DNA-directed DNA polymerase activity" NARROW []
synonym: "iota DNA polymerase activity" NARROW []
synonym: "kappa DNA polymerase activity" NARROW []
synonym: "Klenow fragment" NARROW [EC:2.7.7.7]
synonym: "lambda DNA polymerase activity" NARROW []
synonym: "mu DNA polymerase activity" NARROW []
synonym: "nu DNA polymerase activity" NARROW []
synonym: "sequenase" RELATED [EC:2.7.7.7]
synonym: "sigma DNA polymerase activity" NARROW []
synonym: "Taq DNA polymerase" NARROW [EC:2.7.7.7]
synonym: "Taq Pol I" NARROW [EC:2.7.7.7]
synonym: "Tca DNA polymerase" NARROW [EC:2.7.7.7]
synonym: "theta DNA polymerase activity" NARROW []
synonym: "zeta DNA polymerase activity" NARROW []
xref: EC:2.7.7.-
xref: EC:2.7.7.7
xref: MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN
xref: Reactome:11722 "DNA-directed DNA polymerase activity"
is_a: GO:0034061 ! DNA polymerase activity

[Term]
id: GO:0003892
name: proliferating cell nuclear antigen
namespace: molecular_function
alt_id: GO:0005661
def: "OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair." [ISBN:0123668387]
comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
synonym: "PCNA" EXACT []
is_obsolete: true

[Term]
id: GO:0003896
name: DNA primase activity
namespace: molecular_function
alt_id: GO:0003897
alt_id: GO:0003898
def: "Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase." [GOC:mah, ISBN:0716720094]
subset: gosubset_prok
xref: EC:2.7.7.-
is_a: GO:0003899 ! DNA-directed RNA polymerase activity

[Term]
id: GO:0003899
name: DNA-directed RNA polymerase activity
namespace: molecular_function
alt_id: GO:0000129
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]
subset: gosubset_prok
synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6]
synonym: "C RNA formation factors" RELATED [EC:2.7.7.6]
synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6]
synonym: "DNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6]
synonym: "DNA-dependent RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6]
synonym: "DNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.6]
synonym: "DNA-directed RNA polymerase I activity" NARROW []
synonym: "DNA-directed RNA polymerase II activity" NARROW []
synonym: "DNA-directed RNA polymerase III activity" NARROW []
synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6]
synonym: "RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6]
synonym: "RNA polymerase I activity" NARROW [EC:2.7.7.6]
synonym: "RNA polymerase II activity" NARROW [EC:2.7.7.6]
synonym: "RNA polymerase III activity" NARROW [EC:2.7.7.6]
synonym: "transcriptase" BROAD [EC:2.7.7.6]
xref: EC:2.7.7.6
xref: MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN
xref: Reactome:11745 "DNA-directed RNA polymerase activity"
is_a: GO:0034062 ! RNA polymerase activity

[Term]
id: GO:0003900
name: DNA-directed RNA polymerase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6]
comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase I complex ; GO:0005736'.
is_obsolete: true
replaced_by: GO:0003899

[Term]
id: GO:0003901
name: DNA-directed RNA polymerase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6]
comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase II, core complex ; GO:0005665'.
is_obsolete: true
replaced_by: GO:0003899

[Term]
id: GO:0003902
name: DNA-directed RNA polymerase III activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6]
comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase III complex ; GO:0005666'.
is_obsolete: true
replaced_by: GO:0003899

[Term]
id: GO:0003904
name: deoxyribodipyrimidine photo-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). The enzyme catalyzes the reactivation by light of irradiated DNA. A similar reactivation of irradiated RNA is probably due to a separate enzyme." [EC:4.1.99.3]
comment: Consider also annotating to the molecular function term 'damaged DNA binding ; GO:0003684'.
subset: gosubset_prok
synonym: "deoxyribocyclobutadipyrimidine pyrimidine-lyase activity" EXACT [EC:4.1.99.3]
synonym: "deoxyribodipyrimidine photolyase activity" EXACT []
synonym: "deoxyribonucleate pyrimidine dimer lyase (photosensitive)" EXACT [EC:4.1.99.3]
synonym: "deoxyribonucleic cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3]
synonym: "deoxyribonucleic photolyase activity" EXACT [EC:4.1.99.3]
synonym: "dipyrimidine photolyase (photosensitive)" EXACT [EC:4.1.99.3]
synonym: "DNA cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3]
synonym: "DNA-photoreactivating enzyme" RELATED [EC:4.1.99.3]
synonym: "photolyase activity" EXACT [EC:4.1.99.3]
synonym: "photoreactivating enzyme activity" RELATED [EC:4.1.99.3]
synonym: "phr A photolyase activity" EXACT [EC:4.1.99.3]
synonym: "PhrB photolyase activity" EXACT [EC:4.1.99.3]
synonym: "PRE" RELATED [EC:4.1.99.3]
xref: EC:4.1.99.3
xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN
is_a: GO:0003913 ! DNA photolyase activity

[Term]
id: GO:0003905
name: alkylbase DNA N-glycosylase activity
namespace: molecular_function
alt_id: GO:0004036
def: "Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623]
subset: gosubset_prok
synonym: "3-methyladenine DNA glycosylase II" RELATED [EC:3.2.2.21]
synonym: "AlkA" RELATED [EC:3.2.2.21]
synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.21]
synonym: "alkylbase DNA glycosidase activity" EXACT []
synonym: "deoxyribonucleate 3-methyladenine glycosidase II" RELATED [EC:3.2.2.21]
synonym: "DNA glycosidase II activity" EXACT [EC:3.2.2.21]
synonym: "DNA-3-methyladenine glycosidase II activity" EXACT []
synonym: "DNA-3-methyladenine glycosylase II" RELATED [EC:3.2.2.21]
xref: EC:3.2.2.21
xref: MetaCyc:3.2.2.21-RXN
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0003906
name: DNA-(apurinic or apyrimidinic site) lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18]
comment: Consider also annotating to the molecular function term 'damaged DNA binding ; GO:0003684'.
subset: gosubset_prok
synonym: "AP endonuclease class I activity" NARROW [EC:4.2.99.18]
synonym: "AP lyase activity" EXACT [EC:4.2.99.18]
synonym: "AP site-DNA 5'-phosphomonoester-lyase activity" EXACT [EC:4.2.99.18]
synonym: "deoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [EC:4.2.99.18]
synonym: "DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity" EXACT [EC:4.2.99.18]
synonym: "E. coli endonuclease III" RELATED [EC:4.2.99.18]
synonym: "E. coli endonuclease III activity" NARROW [EC:4.2.99.18]
synonym: "endodeoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [EC:4.2.99.18]
synonym: "endonuclease VIII activity" RELATED []
synonym: "micrococcus luteus UV endonuclease" NARROW [EC:4.2.99.18]
synonym: "Micrococcus luteus UV endonuclease activity" NARROW [EC:4.2.99.18]
synonym: "Phage-T(4) UV endonuclease activity" NARROW [EC:4.2.99.18]
synonym: "phage-T4 UV endonuclease" BROAD [EC:4.2.99.18]
synonym: "Phage-T4 UV endonuclease activity" NARROW [EC:4.2.99.18]
synonym: "X-ray endonuclease III" RELATED [EC:4.2.99.18]
xref: EC:4.2.99.18
xref: MetaCyc:4.2.99.18-RXN
xref: Reactome:12450 "DNA-(apurinic or apyrimidinic site) lyase activity"
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0003908
name: methylated-DNA-[protein]-cysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63]
comment: Consider also annotating to the molecular function term 'damaged DNA binding ; GO:0003684'.
subset: gosubset_prok
synonym: "6-O-methylguanine-DNA methyltransferase activity" EXACT [EC:2.1.1.63]
synonym: "DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity" EXACT []
synonym: "DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63]
synonym: "methylated-DNA-protein-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63]
synonym: "MGMT" EXACT []
synonym: "O-6-methylguanine-DNA-alkyltransferase activity" EXACT [EC:2.1.1.63]
synonym: "O6-alkylguanine-DNA alkyltransferase" BROAD []
xref: EC:2.1.1.63
xref: MetaCyc:2.1.1.63-RXN
xref: Reactome:12455 "methylated-DNA-[protein]-cysteine S-methyltransferase activity"
is_a: GO:0008172 ! S-methyltransferase activity

[Term]
id: GO:0003909
name: DNA ligase activity
namespace: molecular_function
def: "Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another; requires an energy source such as ATP or NAD+." [ISBN:0716720094]
subset: gosubset_prok
xref: EC:6.5.1.-
xref: Reactome:12459 "DNA ligase activity"
is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds

[Term]
id: GO:0003910
name: DNA ligase (ATP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1]
subset: gosubset_prok
synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.1]
synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.1]
synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.1]
synonym: "deoxyribonucleic acid repair enzyme" RELATED [EC:6.5.1.1]
synonym: "deoxyribonucleic acid-joining enzyme" RELATED [EC:6.5.1.1]
synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.1]
synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.1]
synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.1]
synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.1]
synonym: "DNA joinase activity" BROAD [EC:6.5.1.1]
synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.1]
synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.1]
synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.1]
synonym: "polydeoxyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.1]
synonym: "polynucleotide ligase" BROAD [EC:6.5.1.1]
synonym: "polynucleotide ligase (ATP) activity" EXACT [EC:6.5.1.1]
synonym: "sealase activity" RELATED [EC:6.5.1.1]
xref: EC:6.5.1.1
xref: MetaCyc:DNA-LIGASE-ATP-RXN
is_a: GO:0003909 ! DNA ligase activity

[Term]
id: GO:0003911
name: DNA ligase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m)." [EC:6.5.1.2]
subset: gosubset_prok
synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.2]
synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.2]
synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.2]
synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.2]
synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.2]
synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.2]
synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.2]
synonym: "DNA joinase activity" BROAD [EC:6.5.1.2]
synonym: "DNA ligase (NAD)" EXACT [EC:6.5.1.2]
synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.2]
synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.2]
synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)" EXACT [EC:6.5.1.2]
synonym: "Polydeoxyribonucleotide synthase (NAD(+)) activity" EXACT [EC:6.5.1.2]
synonym: "polydeoxyribonucleotide synthase (NAD)" EXACT [EC:6.5.1.2]
synonym: "polydeoxyribonucleotide synthase (NAD+) activity" EXACT [EC:6.5.1.2]
synonym: "polynucleotide ligase" BROAD [EC:6.5.1.2]
synonym: "polynucleotide ligase (NAD(+)) activity" EXACT [EC:6.5.1.2]
synonym: "polynucleotide ligase (NAD)" EXACT [EC:6.5.1.2]
synonym: "polynucleotide ligase (NAD+) activity" EXACT [EC:6.5.1.2]
synonym: "polynucleotide ligase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2]
synonym: "polynucleotide synthetase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2]
synonym: "polynucleotide synthetase activity" EXACT [EC:6.5.1.2]
xref: EC:6.5.1.2
xref: MetaCyc:DNA-LIGASE-NAD+-RXN
is_a: GO:0003909 ! DNA ligase activity

[Term]
id: GO:0003912
name: DNA nucleotidylexotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [EC:2.7.7.31]
synonym: "addase activity" EXACT [EC:2.7.7.31]
synonym: "deoxynucleotidyl terminal transferase activity" EXACT [EC:2.7.7.31]
synonym: "deoxyribonucleic acid nucleotidyltransferase activity" EXACT [EC:2.7.7.31]
synonym: "deoxyribonucleic nucleotidyltransferase activity" EXACT [EC:2.7.7.31]
synonym: "nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [EC:2.7.7.31]
synonym: "TdT" RELATED [EC:2.7.7.31]
synonym: "terminal addition enzyme activity" RELATED [EC:2.7.7.31]
synonym: "terminal deoxynucleotide transferase activity" EXACT [EC:2.7.7.31]
synonym: "terminal deoxynucleotidyltransferase activity" EXACT [EC:2.7.7.31]
synonym: "terminal deoxyribonucleotidyltransferase activity" EXACT [EC:2.7.7.31]
synonym: "terminal transferase activity" EXACT [EC:2.7.7.31]
xref: EC:2.7.7.31
xref: MetaCyc:DNA-NUCLEOTIDYLEXOTRANSFERASE-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0003913
name: DNA photolyase activity
namespace: molecular_function
def: "Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949]
subset: gosubset_prok
xref: EC:4.1.99.-
xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0003914
name: DNA (6-4) photolyase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA." [GOC:mah, PMID:11124949]
is_a: GO:0003913 ! DNA photolyase activity

[Term]
id: GO:0003916
name: DNA topoisomerase activity
namespace: molecular_function
alt_id: GO:0009387
def: "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192]
subset: gosubset_prok
xref: EC:5.99.1.-
xref: MetaCyc:5.99.1.2-RXN
is_a: GO:0003677 ! DNA binding
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0003917
name: DNA topoisomerase type I activity
namespace: molecular_function
def: "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192]
comment: Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity.
subset: gosubset_prok
synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.2]
synonym: "DNA topoisomerase I activity" NARROW []
synonym: "nicking-closing enzyme activity" RELATED [EC:5.99.1.2]
synonym: "omega-protein activity" RELATED [EC:5.99.1.2]
synonym: "relaxing enzyme activity" RELATED [EC:5.99.1.2]
synonym: "swivelase activity" RELATED [EC:5.99.1.2]
synonym: "topoisomerase" BROAD [EC:5.99.1.2]
synonym: "type I DNA topoisomerase activity" EXACT []
synonym: "type I topoisomerase activity" EXACT []
synonym: "untwisting enzyme activity" RELATED [EC:5.99.1.2]
xref: EC:5.99.1.2
xref: MetaCyc:5.99.1.2-RXN
is_a: GO:0003916 ! DNA topoisomerase activity

[Term]
id: GO:0003918
name: DNA topoisomerase (ATP-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192]
subset: gosubset_prok
synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.3]
synonym: "deoxyribonucleic topoisomerase activity" EXACT [EC:5.99.1.3]
synonym: "DNA gyrase activity" EXACT []
synonym: "DNA topoisomerase (ATP-hydrolysing)" BROAD [EC:5.99.1.3]
synonym: "DNA topoisomerase II" RELATED [EC:5.99.1.3]
synonym: "DNA topoisomerase IV activity" EXACT []
synonym: "DNA topoisomerase type II activity" EXACT []
synonym: "DNA-gyrase activity" EXACT [EC:5.99.1.3]
synonym: "topoisomerase" BROAD [EC:5.99.1.3]
synonym: "topoisomerase II" EXACT []
synonym: "type II DNA topoisomerase activity" EXACT [EC:5.99.1.3]
xref: EC:5.99.1.3
xref: MetaCyc:5.99.1.3-RXN
xref: Wikipedia:Type_II_topoisomerase
is_a: GO:0003916 ! DNA topoisomerase activity

[Term]
id: GO:0003919
name: FMN adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + FMN = diphosphate + FAD." [EC:2.7.7.2]
subset: gosubset_prok
synonym: "adenosine triphosphate-riboflavin mononucleotide transadenylase activity" EXACT [EC:2.7.7.2]
synonym: "adenosine triphosphate-riboflavine mononucleotide transadenylase activity" EXACT [EC:2.7.7.2]
synonym: "ATP:FMN adenylyltransferase activity" EXACT []
synonym: "FAD diphosphorylase activity" EXACT [EC:2.7.7.2]
synonym: "FAD pyrophosphorylase activity" EXACT [EC:2.7.7.2]
synonym: "FAD synthetase activity" EXACT [EC:2.7.7.2]
synonym: "flavin adenine dinucleotide synthetase activity" EXACT [EC:2.7.7.2]
synonym: "riboflavin adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.2]
synonym: "riboflavin mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2]
synonym: "riboflavine adenine dinucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2]
xref: EC:2.7.7.2
xref: MetaCyc:FADSYN-RXN
xref: Reactome:12494 "FMN adenylyltransferase activity"
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0003920
name: GMP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH + H+." [EC:1.7.1.7]
comment: Note that this function was formerly EC:1.6.6.8.
subset: gosubset_prok
synonym: "guanosine 5'-monophosphate oxidoreductase activity" EXACT [EC:1.7.1.7]
synonym: "guanosine 5'-monophosphate reductase activity" EXACT [EC:1.7.1.7]
synonym: "guanosine 5'-phosphate reductase activity" EXACT [EC:1.7.1.7]
synonym: "guanosine monophosphate reductase activity" EXACT [EC:1.7.1.7]
synonym: "guanylate reductase activity" RELATED [EC:1.7.1.7]
synonym: "inosine-5'-phosphate:NADP+ oxidoreductase (aminating)" EXACT [EC:1.7.1.7]
synonym: "NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)" EXACT [EC:1.7.1.7]
synonym: "NADPH:GMP oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7]
synonym: "NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7]
xref: EC:1.7.1.7
xref: MetaCyc:GMP-REDUCT-RXN
is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor

[Term]
id: GO:0003921
name: GMP synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + NH3 = AMP + diphosphate + GMP." [EC:6.3.4.1]
synonym: "guanylate synthetase activity" EXACT [EC:6.3.4.1]
synonym: "xanthosine 5'-monophosphate aminase activity" EXACT [EC:6.3.4.1]
synonym: "Xanthosine-5'-phosphate--ammonia ligase activity" EXACT [EC:6.3.4.1]
synonym: "xanthosine-5'-phosphate-ammonia ligase activity" EXACT [EC:6.3.4.1]
synonym: "xanthosine-5'-phosphate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.4.1]
synonym: "XMP aminase activity" EXACT [EC:6.3.4.1]
xref: EC:6.3.4.1
xref: MetaCyc:GMP-SYN-NH3-RXN
xref: Reactome:12506 "GMP synthase activity"
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0003922
name: GMP synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate." [EC:6.3.5.2]
subset: gosubset_prok
synonym: "glutamine amidotransferase activity" EXACT [EC:6.3.5.2]
synonym: "GMP synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2]
synonym: "GMP synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2]
synonym: "GMP synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.2]
synonym: "guanosine 5'-monophosphate synthetase activity" EXACT [EC:6.3.5.2]
synonym: "guanosine monophosphate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2]
synonym: "guanylate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2]
synonym: "xanthosine 5'-phosphate amidotransferase activity" EXACT [EC:6.3.5.2]
synonym: "xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.2]
xref: EC:6.3.5.2
xref: MetaCyc:GMP-SYN-GLUT-RXN
xref: Wikipedia:GMP_synthase_(glutamine-hydrolysing)
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0003923
name: GPI-anchor transamidase activity
namespace: molecular_function
def: "Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor." [ISBN:0471331309 "Biochemical Pathways"]
xref: EC:3.-.-.-
xref: Reactome:12511 "GPI-anchor transamidase activity"
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0003924
name: GTPase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684]
comment: Consider also annotating to the molecular function term 'GTP binding ; GO:0005525'.
subset: gosubset_prok
synonym: "ARF small monomeric GTPase activity" NARROW []
synonym: "dynamin GTPase activity" NARROW []
synonym: "heterotrimeric G-protein GTPase activity" NARROW []
synonym: "heterotrimeric G-protein GTPase, alpha-subunit" RELATED []
synonym: "heterotrimeric G-protein GTPase, beta-subunit" RELATED []
synonym: "heterotrimeric G-protein GTPase, gamma-subunit" RELATED []
synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" BROAD []
synonym: "protein-synthesizing GTPase activity" NARROW []
synonym: "protein-synthesizing GTPase activity, elongation" NARROW []
synonym: "protein-synthesizing GTPase activity, initiation" NARROW []
synonym: "protein-synthesizing GTPase activity, termination" NARROW []
synonym: "Rab small monomeric GTPase activity" NARROW []
synonym: "Ran small monomeric GTPase activity" NARROW []
synonym: "Ras small monomeric GTPase activity" NARROW []
synonym: "RHEB small monomeric GTPase activity" NARROW []
synonym: "Rho small monomeric GTPase activity" NARROW []
synonym: "Sar small monomeric GTPase activity" NARROW []
synonym: "signal-recognition-particle GTPase activity" NARROW []
synonym: "small monomeric GTPase activity" NARROW []
synonym: "tubulin GTPase activity" NARROW []
xref: Reactome:12513 "GTPase activity"
is_a: GO:0017111 ! nucleoside-triphosphatase activity

[Term]
id: GO:0003925
name: small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Small monomeric enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase. They are involved in cell-growth regulation (RAS subfamily), membrane vesicle traffic and uncoating (RAB and ARF subfamilies), nuclear protein import (RAN subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies)." [EC:3.6.5.2, GOC:mah, ISBN:0198547684, MetaCyc:3.6.1.47-RXN]
comment: This term was made obsolete because it represents a gene product and contains cellular component information.
is_obsolete: true
replaced_by: GO:0003924

[Term]
id: GO:0003926
name: ARF small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0016191
consider: GO:0016192

[Term]
id: GO:0003927
name: heterotrimeric G-protein GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. GTP-hydrolyzing enzymes, where GTP and GDP alternate in binding. Includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targeting adenylate cyclase and/or potassium ion and calcium ion channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase." [EC:3.6.5.1, ISBN:0198547684, MetaCyc:3.6.1.46-RXN]
comment: This term was made obsolete because it represents a cellular component.
is_obsolete: true
replaced_by: GO:0003924
replaced_by: GO:0005834

[Term]
id: GO:0003928
name: RAB small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0016191
consider: GO:0016192

[Term]
id: GO:0003929
name: RAN small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0006606

[Term]
id: GO:0003930
name: RAS small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0001558

[Term]
id: GO:0003931
name: Rho small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [EC:3.6.1.47, GOC:mah, ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0007010

[Term]
id: GO:0003932
name: SAR small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0046903

[Term]
id: GO:0003933
name: GTP cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized." [GOC:jl, http://cancerweb.ncl.ac.uk]
subset: gosubset_prok
xref: EC:3.5.4.-
is_a: GO:0019238 ! cyclohydrolase activity

[Term]
id: GO:0003934
name: GTP cyclohydrolase I activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate." [EC:3.5.4.16]
subset: gosubset_prok
synonym: "dihydroneopterin triphosphate synthase activity" EXACT [EC:3.5.4.16]
synonym: "GTP 7,8-8,9-dihydrolase activity" EXACT [EC:3.5.4.16]
synonym: "GTP 8-formylhydrolase activity" EXACT [EC:3.5.4.16]
synonym: "guanosine triphosphate 8-deformylase activity" EXACT [EC:3.5.4.16]
synonym: "guanosine triphosphate cyclohydrolase activity" EXACT [EC:3.5.4.16]
xref: EC:3.5.4.16
xref: MetaCyc:GTP-CYCLOHYDRO-I-RXN
is_a: GO:0003933 ! GTP cyclohydrolase activity

[Term]
id: GO:0003935
name: GTP cyclohydrolase II activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate." [EC:3.5.4.25]
subset: gosubset_prok
synonym: "GTP 7,8-8,9-dihydrolase (diphosphate-forming)" EXACT [EC:3.5.4.25]
synonym: "GTP-8-formylhydrolase activity" EXACT [EC:3.5.4.25]
synonym: "guanosine triphosphate cyclohydrolase II" RELATED [EC:3.5.4.25]
xref: EC:3.5.4.25
xref: MetaCyc:GTP-CYCLOHYDRO-II-RXN
is_a: GO:0003933 ! GTP cyclohydrolase activity

[Term]
id: GO:0003936
name: hydrogen-transporting two-sector ATPase activity
namespace: molecular_function
alt_id: GO:0004006
alt_id: GO:0008729
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)." [EC:3.6.3.14, TC:3.A.3.-.-]
comment: This term was made obsolete because it refers to a bifunctional gene product.
synonym: "proton-transporting two-sector ATPase activity" EXACT []
is_obsolete: true
consider: GO:0046933
consider: GO:0046961

[Term]
id: GO:0003937
name: IMP cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [EC:3.5.4.10]
subset: gosubset_prok
synonym: "IMP 1,2-hydrolase (decyclizing)" EXACT [EC:3.5.4.10]
synonym: "IMP synthetase activity" EXACT [EC:3.5.4.10]
synonym: "inosinate cyclohydrolase activity" EXACT [EC:3.5.4.10]
synonym: "inosinicase activity" EXACT [EC:3.5.4.10]
xref: EC:3.5.4.10
xref: MetaCyc:IMPCYCLOHYDROLASE-RXN
xref: Reactome:12558 "IMP cyclohydrolase activity"
is_a: GO:0019238 ! cyclohydrolase activity

[Term]
id: GO:0003938
name: IMP dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205]
subset: gosubset_prok
synonym: "IMP oxidoreductase activity" EXACT [EC:1.1.1.205]
synonym: "IMP:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.205]
synonym: "inosinate dehydrogenase activity" RELATED [EC:1.1.1.205]
synonym: "inosine 5'-monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205]
synonym: "inosine monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205]
synonym: "inosine monophosphate oxidoreductase activity" EXACT [EC:1.1.1.205]
synonym: "inosine-5'-phosphate dehydrogenase activity" EXACT [EC:1.1.1.205]
synonym: "inosinic acid dehydrogenase activity" RELATED [EC:1.1.1.205]
xref: EC:1.1.1.205
xref: MetaCyc:IMP-DEHYDROG-RXN
xref: Reactome:12563 "IMP dehydrogenase activity"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003939
name: L-iditol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14]
comment: Note that enzymes with this activity also act on D-glucitol (giving D-fructose) and other closely related sugar alcohols.
subset: gosubset_prok
synonym: " L-iditol:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.14]
synonym: "glucitol dehydrogenase activity" RELATED [EC:1.1.1.14]
synonym: "L-iditol (sorbitol) dehydrogenase activity" RELATED [EC:1.1.1.14]
synonym: "L-iditol:NAD oxidoreductase activity" EXACT [EC:1.1.1.14]
synonym: "NAD+-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14]
synonym: "NAD-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14]
synonym: "NAD-sorbitol dehydrogenase" RELATED [EC:1.1.1.14]
synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.1.14]
synonym: "sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14]
xref: EC:1.1.1.14
xref: MetaCyc:L-IDITOL-2-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003940
name: L-iduronidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in desulfated dermatan." [EC:3.2.1.76]
synonym: "alpha-L-iduronidase activity" EXACT [EC:3.2.1.76]
synonym: "glycosaminoglycan alpha-L-iduronohydrolase activity" EXACT [EC:3.2.1.76]
xref: EC:3.2.1.76
xref: MetaCyc:3.2.1.76-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0003941
name: L-serine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine = pyruvate + NH3." [EC:4.3.1.17]
comment: Note that this function was formerly EC:4.3.1.13.
subset: gosubset_prok
synonym: "L-hydroxyaminoacid dehydratase activity" BROAD []
synonym: "L-serine ammonia-lyase (pyruvate-forming) activity" EXACT [EC:4.3.1.17]
synonym: "L-serine deaminase activity" EXACT []
synonym: "L-serine dehydratase activity" BROAD [EC:4.3.1.17]
synonym: "L-serine hydro-lyase (deaminating) activity" EXACT []
synonym: "serine deaminase activity" BROAD [EC:4.3.1.17]
xref: EC:4.3.1.17
xref: MetaCyc:4.3.1.17-RXN
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0003942
name: N-acetyl-gamma-glutamyl-phosphate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+." [EC:1.2.1.38]
subset: gosubset_prok
synonym: "N-acetyl-glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38]
synonym: "N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38]
synonym: "N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38]
synonym: "N-acetylglutamate 5-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38]
synonym: "N-acetylglutamic gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38]
synonym: "NAGSA dehydrogenase activity" BROAD [EC:1.2.1.38]
synonym: "reductase, acetyl-gamma-glutamyl phosphate" EXACT [EC:1.2.1.38]
xref: EC:1.2.1.38
xref: MetaCyc:N-ACETYLGLUTPREDUCT-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003943
name: N-acetylgalactosamine-4-sulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12]
subset: gosubset_prok
synonym: "acetylgalactosamine 4-sulfatase activity" EXACT [EC:3.1.6.12]
synonym: "arylsulfatase B" EXACT []
synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.12]
synonym: "N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" EXACT [EC:3.1.6.12]
synonym: "N-acetylgalactosamine 4-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.12]
synonym: "N-acetylgalactosamine-4-sulphatase activity" EXACT []
xref: EC:3.1.6.12
xref: MetaCyc:3.1.6.12-RXN
xref: Wikipedia:Arylsulfatase_B
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0003944
name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose." [EC:3.1.4.45]
synonym: "2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity" EXACT [EC:3.1.4.45]
synonym: "alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity" EXACT [EC:3.1.4.45]
synonym: "alpha-N-acetylglucosaminyl phosphodiesterase activity" EXACT [EC:3.1.4.45]
synonym: "glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity" EXACT [EC:3.1.4.45]
synonym: "lysosomal alpha-N-acetylglucosaminidase activity" NARROW [EC:3.1.4.45]
synonym: "phosphodiester glycosidase activity" EXACT [EC:3.1.4.45]
xref: EC:3.1.4.45
xref: MetaCyc:3.1.4.45-RXN
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0003945
name: N-acetyllactosamine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90]
subset: gosubset_prok
synonym: "acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90]
synonym: "beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "beta-N-acetylglucosaminide beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "beta1-4GalT" RELATED [EC:2.4.1.90]
synonym: "Gal-T" RELATED [EC:2.4.1.90]
synonym: "lactosamine synthase activity" EXACT [EC:2.4.1.90]
synonym: "lactosamine synthetase activity" EXACT [EC:2.4.1.90]
synonym: "lactose synthetase A protein" RELATED [EC:2.4.1.90]
synonym: "N-acetylglucosamine (beta-1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "N-acetylglucosamine (beta1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "N-acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90]
synonym: "NAL synthetase activity" EXACT [EC:2.4.1.90]
synonym: "UDP-beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDP-galactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDP-galactose-N-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT []
synonym: "UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase activity" EXACT [EC:2.4.1.90]
synonym: "uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90]
xref: EC:2.4.1.90
xref: MetaCyc:N-ACETYLLACTOSAMINE-SYNTHASE-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0003947
name: (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide." [EC:2.4.1.92]
synonym: "asialo-GM2 synthase activity" EXACT [EC:2.4.1.92]
synonym: "beta-1,4N-aetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92]
synonym: "GalNAc-T activity" EXACT [EC:2.4.1.92]
synonym: "ganglioside GM2 synthase activity" EXACT [EC:2.4.1.92]
synonym: "ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92]
synonym: "GM2 synthase activity" EXACT [EC:2.4.1.92]
synonym: "GM2/GD2-synthase activity" EXACT [EC:2.4.1.92]
synonym: "UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92]
synonym: "UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92]
synonym: "UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92]
synonym: "UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92]
synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92]
synonym: "uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92]
synonym: "uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92]
xref: EC:2.4.1.92
xref: MetaCyc:2.4.1.92-RXN
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0003948
name: N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-glucosaminylamine + L-aspartate." [EC:3.5.1.26]
subset: gosubset_prok
synonym: "4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26]
synonym: "aspartylglucosaminidase activity" EXACT [EC:3.5.1.26]
synonym: "aspartylglucosylaminase activity" EXACT [EC:3.5.1.26]
synonym: "aspartylglucosylamine deaspartylase activity" EXACT [EC:3.5.1.26]
synonym: "aspartylglucosylaminidase activity" EXACT [EC:3.5.1.26]
synonym: "aspartylglycosylamine amidohydrolase activity" EXACT [EC:3.5.1.26]
synonym: "beta-aspartylglucosylamine amidohydrolase activity" EXACT [EC:3.5.1.26]
synonym: "glucosylamidase activity" RELATED [EC:3.5.1.26]
synonym: "glycosylasparaginase activity" EXACT [EC:3.5.1.26]
synonym: "N-aspartyl-beta-glucosaminidase activity" EXACT [EC:3.5.1.26]
synonym: "N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26]
xref: EC:3.5.1.26
xref: MetaCyc:3.5.1.26-RXN
is_a: GO:0004067 ! asparaginase activity

[Term]
id: GO:0003949
name: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide = N-(5'-phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide." [EC:5.3.1.16]
subset: gosubset_prok
synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity" EXACT [EC:5.3.1.16]
synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity" EXACT [EC:5.3.1.16]
synonym: "N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16]
synonym: "N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16]
synonym: "phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity" EXACT [EC:5.3.1.16]
synonym: "phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16]
xref: EC:5.3.1.16
xref: MetaCyc:PRIBFAICARPISOM-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0003950
name: NAD+ ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]
subset: gosubset_prok
synonym: "ADP-ribosyltransferase (polymerizing) activity" EXACT [EC:2.4.2.30]
synonym: "NAD ADP-ribosyltransferase activity" EXACT []
synonym: "NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [EC:2.4.2.30]
synonym: "poly(adenosine diphosphate ribose) polymerase activity" EXACT [EC:2.4.2.30]
synonym: "poly(ADP-ribose) synthase activity" EXACT [EC:2.4.2.30]
synonym: "poly(ADP-ribose) synthetase activity" EXACT [EC:2.4.2.30]
synonym: "poly(ADP-ribose)polymerase activity" EXACT [EC:2.4.2.30]
xref: EC:2.4.2.30
xref: MetaCyc:NAD+-ADP-RIBOSYLTRANSFERASE-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0003951
name: NAD+ kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + NAD+ = ADP + NADP+." [EC:2.7.1.23]
subset: gosubset_prok
synonym: "ATP:NAD+ 2'-phosphotransferase activity" EXACT [EC:2.7.1.23]
synonym: "DPN kinase activity" RELATED [EC:2.7.1.23]
synonym: "NAD kinase activity" EXACT []
synonym: "NADK" RELATED [EC:2.7.1.23]
synonym: "nicotinamide adenine dinucleotide kinase (phosphorylating)" EXACT [EC:2.7.1.23]
synonym: "nicotinamide adenine dinucleotide kinase activity" EXACT [EC:2.7.1.23]
xref: EC:2.7.1.23
xref: MetaCyc:NAD-KIN-RXN
xref: Reactome:12598 "NAD+ kinase activity"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0003952
name: NAD+ synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate." [EC:6.3.5.1]
subset: gosubset_prok
synonym: "deamido-NAD+:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.1]
synonym: "desamidonicotinamide adenine dinucleotide amidotransferase activity" EXACT [EC:6.3.5.1]
synonym: "DPN synthetase activity" EXACT [EC:6.3.5.1]
synonym: "NAD synthase (glutamine-hydrolyzing) activity" EXACT []
synonym: "NAD synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1]
synonym: "NAD(+) synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.1]
synonym: "NAD+ synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1]
synonym: "NAD+ synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.1]
synonym: "nicotinamide adenine dinucleotide synthetase (glutamine) activity" EXACT [EC:6.3.5.1]
xref: EC:6.3.5.1
xref: MetaCyc:NAD-SYNTH-GLN-RXN
xref: Reactome:12600 "NAD+ synthase (glutamine-hydrolyzing) activity"
xref: Wikipedia:NAD+_synthase_(glutamine-hydrolysing)
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0003953
name: NAD+ nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [EC:3.2.2.5]
subset: gosubset_prok
synonym: "ADP-ribosyl cyclase activity" RELATED [EC:3.2.2.5]
synonym: "diphosphopyridine nucleosidase activity" EXACT [EC:3.2.2.5]
synonym: "DPN hydrolase activity" EXACT [EC:3.2.2.5]
synonym: "DPNase activity" EXACT [EC:3.2.2.5]
synonym: "NAD glycohydrolase activity" EXACT [EC:3.2.2.5]
synonym: "NAD hydrolase activity" EXACT [EC:3.2.2.5]
synonym: "NAD nucleosidase activity" EXACT []
synonym: "NAD+ glycohydrolase activity" EXACT [EC:3.2.2.5]
synonym: "NADase activity" EXACT [EC:3.2.2.5]
synonym: "nicotinamide adenine dinucleotide glycohydrolase activity" EXACT [EC:3.2.2.5]
synonym: "nicotinamide adenine dinucleotide nucleosidase activity" EXACT [EC:3.2.2.5]
xref: EC:3.2.2.5
xref: MetaCyc:NADNUCLEOSID-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0003954
name: NADH dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3]
subset: gosubset_prok
synonym: "beta-NADH dehydrogenase dinucleotide activity" EXACT [EC:1.6.99.3]
synonym: "cytochrome c reductase activity" RELATED [EC:1.6.99.3]
synonym: "diaphorase activity" BROAD [EC:1.6.99.3]
synonym: "dihydrocodehydrogenase I dehydrogenase activity" EXACT [EC:1.6.99.3]
synonym: "dihydronicotinamide adenine dinucleotide dehydrogenase activity" EXACT [EC:1.6.99.3]
synonym: "diphosphopyridine diaphorase activity" EXACT [EC:1.6.99.3]
synonym: "diphosphopyrinase activity" EXACT [EC:1.6.99.3]
synonym: "DPNH diaphorase activity" EXACT [EC:1.6.99.3]
synonym: "NADH diaphorase activity" EXACT [EC:1.6.99.3]
synonym: "NADH hydrogenase activity" EXACT [EC:1.6.99.3]
synonym: "NADH oxidoreductase activity" EXACT [EC:1.6.99.3]
synonym: "NADH-menadione oxidoreductase activity" NARROW [EC:1.6.99.3]
synonym: "NADH2 dehydrogenase activity" EXACT [EC:1.6.99.3]
synonym: "NADH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.3]
synonym: "NADH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.3]
synonym: "NADH:cytochrome c oxidoreductase activity" NARROW [EC:1.6.99.3]
synonym: "reduced diphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.3]
synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.99.3]
synonym: "type I dehydrogenase activity" RELATED [EC:1.6.99.3]
xref: EC:1.6.99.3
xref: MetaCyc:NADH-DEHYDROGENASE-RXN
is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH

[Term]
id: GO:0003955
name: NAD(P)H dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)(+) + a hydroquinone." [EC:1.6.5.2]
subset: gosubset_prok
synonym: "azoreductase activity" BROAD [EC:1.6.5.2]
synonym: "dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity" EXACT [EC:1.6.5.2]
synonym: "diaphorase activity" BROAD [EC:1.6.5.2]
synonym: "DT-diaphorase activity" EXACT [EC:1.6.5.2]
synonym: "flavoprotein NAD(P)H-quinone reductase activity" EXACT [EC:1.6.5.2]
synonym: "menadione oxidoreductase activity" NARROW [EC:1.6.5.2]
synonym: "menadione reductase activity" NARROW [EC:1.6.5.2]
synonym: "NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2]
synonym: "NAD(P)H menadione reductase activity" BROAD [EC:1.6.5.2]
synonym: "NAD(P)H(2) dehydrogenase (quinone) activity" EXACT [EC:1.6.5.2]
synonym: "NAD(P)H-quinone dehydrogenase activity" EXACT [EC:1.6.5.2]
synonym: "NAD(P)H-quinone oxidoreductase activity" EXACT [EC:1.6.5.2]
synonym: "NAD(P)H2 dehydrogenase (quinone)" EXACT [EC:1.6.5.2]
synonym: "NAD(P)H: menadione oxidoreductase activity" BROAD [EC:1.6.5.2]
synonym: "NAD(P)H:(quinone-acceptor)oxidoreductase activity" EXACT [EC:1.6.5.2]
synonym: "NAD(P)H:quinone oxidoreductase activity" EXACT [EC:1.6.5.2]
synonym: "NADH-menadione reductase activity" NARROW [EC:1.6.5.2]
synonym: "naphthoquinone reductase activity" EXACT [EC:1.6.5.2]
synonym: "Naphthoquinone reductase activity" NARROW [EC:1.6.5.2]
synonym: "NQO1" RELATED [EC:1.6.5.2]
synonym: "p-benzoquinone reductase activity" NARROW [EC:1.6.5.2]
synonym: "phylloquinone reductase activity" NARROW [EC:1.6.5.2]
synonym: "QR1" RELATED [EC:1.6.5.2]
synonym: "quinone reductase activity" EXACT [EC:1.6.5.2]
synonym: "reduced NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2]
synonym: "reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity" EXACT [EC:1.6.5.2]
synonym: "viologen accepting pyridine nucleotide oxidoreductase activity" NARROW [EC:1.6.5.2]
synonym: "vitamin K reductase activity" NARROW [EC:1.6.5.2]
synonym: "vitamin-K reductase activity" NARROW [EC:1.6.5.2]
xref: EC:1.6.5.2
xref: MetaCyc:NQOR-RXN
xref: UM-BBD_enzymeID:e0202
is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor

[Term]
id: GO:0003956
name: NAD(P)+-protein-arginine ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [EC:2.4.2.31]
synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.31]
synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.31]
synonym: "mono(ADPribosyl)transferase activity" BROAD [EC:2.4.2.31]
synonym: "NAD(+):L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31]
synonym: "NAD(P)(+)--arginine ADP-ribosyltransferase activity" EXACT [EC:2.4.2.31]
synonym: "NAD(P)+-arginine ADP-ribosyltransferase activity" EXACT []
synonym: "NAD(P)+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31]
synonym: "NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31]
synonym: "NAD(P)-arginine ADP-ribosyltransferase activity" EXACT []
synonym: "NAD+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31]
synonym: "peptidyl-arginine ADP-ribosylation activity" EXACT []
synonym: "protein-arginine ADP-ribosyltransferase activity" EXACT []
xref: EC:2.4.2.31
xref: MetaCyc:2.4.2.31-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0003957
name: NAD(P)+ transhydrogenase (B-specific) activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+." [EC:1.6.1.1, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf?sessid=6006l3]
subset: gosubset_prok
synonym: "H+-thase" BROAD [EC:1.6.1.1]
synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "NAD(P) transhydrogenase (B-specific) activity" EXACT []
synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1]
synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "NADPH:NAD+ oxidoreductase (B-specific)" EXACT [EC:1.6.1.1]
synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1]
synonym: "nicotinamide nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1]
synonym: "non-energy-linked transhydrogenase activity" EXACT [EC:1.6.1.1]
synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1]
synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1]
xref: EC:1.6.1.1
xref: MetaCyc:PYRNUTRANSHYDROGEN-RXN
is_a: GO:0008746 ! NAD(P) transhydrogenase activity
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity

[Term]
id: GO:0003958
name: NADPH-hemoprotein reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [EC:1.6.2.4]
subset: gosubset_prok
synonym: "aldehyde reductase (NADPH-dependent) activity" RELATED [EC:1.6.2.4]
synonym: "CPR activity" RELATED [EC:1.6.2.4]
synonym: "cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity" NARROW [EC:1.6.2.4]
synonym: "cytochrome P-450 reductase activity" EXACT [EC:1.6.2.4]
synonym: "cytochrome P450 reductase activity" NARROW [EC:1.6.2.4]
synonym: "dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "FAD-cytochrome c reductase activity" RELATED [EC:1.6.2.4]
synonym: "ferrihemoprotein P-450 reductase activity" RELATED [EC:1.6.2.4]
synonym: "NADP--cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADP--cytochrome reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--cytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--cytochrome P450 oxidoreductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--cytochrome P450 reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--ferricytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH--ferrihemoprotein reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH-cytochrome P-450 oxidoreductase activity" EXACT [EC:1.6.2.4]
synonym: "NADPH-cytochrome p-450 reductase activity" EXACT [EC:1.6.2.4]
synonym: "NADPH-dependent cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "NADPH-ferrihemoprotein reductase activity" EXACT []
synonym: "NADPH:cytochrome c reductase activity" EXACT []
synonym: "NADPH:cytochrome P450 reductase activity" EXACT []
synonym: "NADPH:ferrihemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4]
synonym: "NADPH:hemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4]
synonym: "NADPH:P-450 reductase activity" EXACT [EC:1.6.2.4]
synonym: "NADPH:P450 reductase activity" NARROW [EC:1.6.2.4]
synonym: "POR" RELATED [EC:1.6.2.4]
synonym: "reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity" NARROW [EC:1.6.2.4]
synonym: "TPNH(2) cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "TPNH-cytochrome c reductase activity" NARROW [EC:1.6.2.4]
synonym: "TPNH2 cytochrome c reductase activity" EXACT [EC:1.6.2.4]
xref: EC:1.6.2.4
xref: MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN
is_a: GO:0016653 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor

[Term]
id: GO:0003959
name: NADPH dehydrogenase activity
namespace: molecular_function
alt_id: GO:0008468
alt_id: GO:0016660
def: "Catalysis of the reaction: NADPH + H+ + quinone acceptor = NADP+ + hydroquinone." [EC:1.6.99.1]
subset: gosubset_prok
synonym: "dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1]
synonym: "NADPH diaphorase activity" EXACT [EC:1.6.99.1]
synonym: "NADPH-dehydrogenase activity" EXACT [EC:1.6.99.1]
synonym: "NADPH2 diaphorase activity" EXACT [EC:1.6.99.1]
synonym: "NADPH2-dehydrogenase activity" EXACT [EC:1.6.99.1]
synonym: "NADPH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.1]
synonym: "NADPH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.1]
synonym: "old yellow enzyme" RELATED [EC:1.6.99.1]
synonym: "OYE" RELATED [EC:1.6.99.1]
synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1]
synonym: "TPNH dehydrogenase activity" EXACT [EC:1.6.99.1]
synonym: "TPNH-diaphorase activity" EXACT [EC:1.6.99.1]
synonym: "triphosphopyridine diaphorase activity" EXACT [EC:1.6.99.1]
synonym: "triphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.1]
xref: EC:1.6.99.1
xref: MetaCyc:NADPH-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0523
is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH

[Term]
id: GO:0003960
name: NADPH:quinone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5]
subset: gosubset_prok
synonym: "NADPH:quinone oxidoreductase activity" EXACT [EC:1.6.5.5]
synonym: "quinone oxidoreductase activity" BROAD [EC:1.6.5.5]
synonym: "zeta-crystallin activity" NARROW [EC:1.6.5.5]
xref: EC:1.6.5.5
xref: MetaCyc:QOR-RXN
is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor

[Term]
id: GO:0003961
name: O-acetylhomoserine aminocarboxypropyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate." [EC:2.5.1.49]
comment: Note that this function was formerly EC:4.2.99.10.
subset: gosubset_prok
synonym: "4.2.99.9" RELATED []
synonym: "O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity" EXACT [EC:2.5.1.49]
synonym: "O-acetyl-L-homoserine sulfhydrolase activity" EXACT [EC:2.5.1.49]
synonym: "O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.49]
synonym: "O-acetylhomoserine (thiol)-lyase activity" EXACT []
synonym: "O-acetylhomoserine sulfhydrolase activity" EXACT [EC:2.5.1.49]
synonym: "OAH sulfhydrylase activity" EXACT [EC:2.5.1.49]
xref: EC:2.5.1.49
xref: MetaCyc:O-ACETYLHOMOSERINE-THIOL-LYASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0003962
name: cystathionine gamma-synthase activity
namespace: molecular_function
alt_id: GO:0000505
def: "Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate." [EC:2.5.1.48]
comment: Formerly EC 4.2.99.9.
subset: gosubset_prok
synonym: "CTT gamma synthase activity" EXACT []
synonym: "cystathionine g-synthase activity" EXACT []
synonym: "cystathionine gamma synthase activity" EXACT []
synonym: "cystathionine synthase activity" EXACT [EC:2.5.1.48]
synonym: "cystathionine synthetase activity" EXACT [EC:2.5.1.48]
synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.5.1.48]
synonym: "homoserine transsuccinylase activity" BROAD [EC:2.5.1.48]
synonym: "O-succinyl-L-homoserine (thiol)-lyase activity" EXACT []
synonym: "O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity" EXACT [EC:2.5.1.48]
synonym: "O-succinyl-L-homoserine succinate-lyase activity" EXACT []
synonym: "O-succinylhomoserine (thiol)-lyase activity" EXACT [EC:2.5.1.48]
synonym: "O-succinylhomoserine synthase activity" EXACT [EC:2.5.1.48]
synonym: "O-succinylhomoserine synthetase activity" EXACT [EC:2.5.1.48]
synonym: "O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.48]
xref: EC:2.5.1.48
xref: MetaCyc:O-SUCCHOMOSERLYASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0003963
name: RNA-3'-phosphate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate." [EC:6.5.1.4]
subset: gosubset_prok
synonym: "RNA 3'-terminal phosphate cyclase activity" EXACT [EC:6.5.1.4]
synonym: "RNA cyclase activity" EXACT [EC:6.5.1.4]
synonym: "RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)" EXACT [EC:6.5.1.4]
xref: EC:6.5.1.4
xref: MetaCyc:RNA-3-PHOSPHATE-CYCLASE-RXN
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds

[Term]
id: GO:0003964
name: RNA-directed DNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]
subset: gosubset_prok
synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49]
synonym: "DNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49]
synonym: "reverse transcriptase activity" EXACT [EC:2.7.7.49]
synonym: "revertase activity" RELATED [EC:2.7.7.49]
synonym: "RNA revertase activity" EXACT [EC:2.7.7.49]
synonym: "RNA-dependent deoxyribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.49]
synonym: "RNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.49]
synonym: "RNA-directed DNA polymerase, group II intron encoded" NARROW []
synonym: "RNA-directed DNA polymerase, transposon encoded" NARROW []
synonym: "RNA-instructed DNA polymerase activity" EXACT [EC:2.7.7.49]
synonym: "RT" RELATED [EC:2.7.7.49]
xref: EC:2.7.7.49
xref: MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN
xref: Reactome:10568 "RNA-directed DNA polymerase activity"
is_a: GO:0034061 ! DNA polymerase activity

[Term]
id: GO:0003966
name: RNA-directed DNA polymerase, transposon encoded
namespace: molecular_function
def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49]
comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'.
is_obsolete: true
replaced_by: GO:0003964

[Term]
id: GO:0003967
name: RNA-directed DNA polymerase, group II intron encoded
namespace: molecular_function
def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49]
comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'.
is_obsolete: true
replaced_by: GO:0003964

[Term]
id: GO:0003968
name: RNA-directed RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA (n) = diphosphate + RNA (n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah]
subset: gosubset_prok
synonym: "3D polymerase activity" EXACT [EC:2.7.7.48]
synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [EC:2.7.7.48]
synonym: "PB1 proteins" RELATED [EC:2.7.7.48]
synonym: "PB2 proteins" RELATED [EC:2.7.7.48]
synonym: "phage f2 replicase" NARROW [EC:2.7.7.48]
synonym: "polymerase L" RELATED [EC:2.7.7.48]
synonym: "Q-beta replicase activity" EXACT [EC:2.7.7.48]
synonym: "RDRP" RELATED [EC:2.7.7.48]
synonym: "ribonucleic acid replicase activity" EXACT [EC:2.7.7.48]
synonym: "ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48]
synonym: "ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.48]
synonym: "ribonucleic replicase activity" EXACT [EC:2.7.7.48]
synonym: "ribonucleic synthetase activity" RELATED [EC:2.7.7.48]
synonym: "RNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.48]
synonym: "RNA replicase activity" EXACT [EC:2.7.7.48]
synonym: "RNA synthetase activity" RELATED [EC:2.7.7.48]
synonym: "RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48]
synonym: "RNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.48]
synonym: "RNA-dependent RNA replicase activity" EXACT [EC:2.7.7.48]
synonym: "transcriptase" BROAD [EC:2.7.7.48]
xref: EC:2.7.7.48
xref: MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN
xref: Reactome:12642 "RNA-directed RNA polymerase activity"
is_a: GO:0034062 ! RNA polymerase activity

[Term]
id: GO:0003969
name: RNA editase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a biological process.
is_obsolete: true

[Term]
id: GO:0003972
name: RNA ligase (ATP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + ribonucleotide (n) + ribonucleotide (m) = AMP + diphosphate + ribonucleotide (n+m)." [EC:6.5.1.3]
subset: gosubset_prok
synonym: "poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.3]
synonym: "polyribonucleotide ligase activity" EXACT [EC:6.5.1.3]
synonym: "polyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.3]
synonym: "ribonucleic ligase activity" BROAD [EC:6.5.1.3]
xref: EC:6.5.1.3
xref: MetaCyc:RNA-LIGASE-ATP-RXN
is_a: GO:0008452 ! RNA ligase activity

[Term]
id: GO:0003973
name: (S)-2-hydroxy-acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + H2O2." [EC:1.1.3.15]
subset: gosubset_prok
synonym: "(S)-2-hydroxy-acid:oxygen 2-oxidoreductase" EXACT [EC:1.1.3.15]
synonym: "hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15]
synonym: "hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15]
synonym: "hydroxyacid oxidase A" RELATED [EC:1.1.3.15]
synonym: "L-2-hydroxy acid oxidase" EXACT [EC:1.1.3.15]
synonym: "L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15]
synonym: "oxidase, L-2-hydroxy acid" EXACT [EC:1.1.3.15]
xref: EC:1.1.3.15
xref: MetaCyc:S-2-HYDROXY-ACID-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0003974
name: UDP-N-acetylglucosamine 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7]
subset: gosubset_prok
synonym: "UDP acetylglucosamine epimerase activity" EXACT [EC:5.1.3.7]
synonym: "UDP-GlcNAc 4-epimerase activity" EXACT [EC:5.1.3.7]
synonym: "UDP-N-acetyl-D-glucosamine 4-epimerase activity" EXACT [EC:5.1.3.7]
synonym: "uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7]
synonym: "uridine diphosphate N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7]
synonym: "uridine diphosphoacetylglucosamine epimerase activity" EXACT [EC:5.1.3.7]
xref: EC:5.1.3.7
xref: MetaCyc:UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0003975
name: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol." [EC:2.7.8.15]
subset: gosubset_prok
synonym: "chitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.7.8.15]
synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15]
synonym: "GlcNAc-1-P transferase activity" EXACT [EC:2.7.8.15]
synonym: "N-acetylglucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15]
synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity" EXACT [EC:2.7.8.15]
synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15]
synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity" EXACT [EC:2.7.8.15]
synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity" EXACT [EC:2.7.8.15]
synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15]
synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity" EXACT [EC:2.7.8.15]
synonym: "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity" EXACT []
synonym: "uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15]
xref: EC:2.7.8.15
xref: MetaCyc:2.7.8.15-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0003976
name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose." [EC:2.7.8.17]
synonym: "lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17]
synonym: "N-acetylglucosaminyl phosphotransferase activity" EXACT [EC:2.7.8.17]
synonym: "N-acetylglucosaminylphosphotransferase activity" RELATED [EC:2.7.8.17]
synonym: "UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17]
synonym: "UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity" EXACT [EC:2.7.8.17]
synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17]
synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity" EXACT [EC:2.7.8.17]
synonym: "UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17]
xref: EC:2.7.8.17
xref: MetaCyc:2.7.8.17-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0003977
name: UDP-N-acetylglucosamine diphosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-glucosamine." [EC:2.7.7.23]
subset: gosubset_prok
synonym: "acetylglucosamine 1-phosphate uridylyltransferase" BROAD [EC:2.7.7.23]
synonym: "GlmU uridylyltransferase activity" EXACT [EC:2.7.7.23]
synonym: "N-acetylglucosamine-1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.23]
synonym: "UDP-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23]
synonym: "UDP-GlcNAc pyrophosphorylase activity" EXACT [EC:2.7.7.23]
synonym: "UDP-N-acetylglucosamine pyrophosphorylase activity" EXACT []
synonym: "uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23]
synonym: "uridine diphosphoacetylglucosamine phosphorylase activity" EXACT [EC:2.7.7.23]
synonym: "uridine diphosphoacetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23]
synonym: "UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23]
synonym: "UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23]
xref: EC:2.7.7.23
xref: MetaCyc:NAG1P-URIDYLTRANS-RXN
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0003978
name: UDP-glucose 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2]
subset: gosubset_prok
synonym: "4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "galactowaldenase activity" RELATED [EC:5.1.3.2]
synonym: "UDP-D-galactose 4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "UDP-galactose 4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "UDP-glucose epimerase activity" EXACT [EC:5.1.3.2]
synonym: "UDPG-4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "UDPgalactose 4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "UDPglucose 4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "uridine diphosphate galactose 4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "uridine diphosphate glucose 4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "uridine diphospho-galactose-4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "uridine diphosphoglucose 4-epimerase activity" EXACT [EC:5.1.3.2]
synonym: "uridine diphosphoglucose epimerase activity" EXACT [EC:5.1.3.2]
xref: EC:5.1.3.2
xref: MetaCyc:UDPGLUCEPIM-RXN
xref: Reactome:12673 "UDP-glucose 4-epimerase activity"
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0003979
name: UDP-glucose 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH + H+." [EC:1.1.1.22]
subset: gosubset_prok
xref: EC:1.1.1.22
xref: MetaCyc:UGD-RXN
xref: Reactome:12674 "UDP-glucose 6-dehydrogenase activity"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0003980
name: UDP-glucose:glycoprotein glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins." [PMID:10764828]
synonym: "UGGT activity" EXACT []
xref: EC:2.4.1.-
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0003983
name: UTP:glucose-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose." [EC:2.7.7.9]
subset: gosubset_prok
synonym: "glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9]
synonym: "UDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "UDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "UDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "UDPG phosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "UDPG pyrophosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "uridine 5'-diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "uridine diphosphate-D-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "uridine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "uridine-diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9]
synonym: "UTP-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9]
synonym: "UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9]
xref: EC:2.7.7.9
xref: MetaCyc:GLUC1PURIDYLTRANS-RXN
xref: Reactome:12708 "UTP:glucose-1-phosphate uridylyltransferase activity"
is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity

[Term]
id: GO:0003984
name: acetolactate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2." [EC:2.2.1.6]
comment: Note that this function was formerly EC:4.1.3.18.
subset: gosubset_prok
synonym: "acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6]
synonym: "acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6]
synonym: "acetolactate pyruvate-lyase (carboxylating) activity" EXACT [EC:2.2.1.6]
synonym: "acetolactic synthetase activity" EXACT [EC:2.2.1.6]
synonym: "alpha-acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6]
synonym: "alpha-acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6]
synonym: "alpha-acetolactate synthase activity" EXACT [EC:2.2.1.6]
synonym: "alpha-acetolactate synthetase activity" EXACT [EC:2.2.1.6]
synonym: "pyruvate:pyruvate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.6]
xref: EC:2.2.1.6
xref: MetaCyc:ACETOLACTSYN-RXN
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0003985
name: acetyl-CoA C-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA." [EC:2.3.1.9]
subset: gosubset_prok
synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.9]
synonym: "3-oxothiolase activity" EXACT [EC:2.3.1.9]
synonym: "acetoacetyl-CoA thiolase activity" EXACT [EC:2.3.1.9]
synonym: "acetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9]
synonym: "acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.9]
synonym: "acetyl-CoA:acetyl-CoA C-acetyltransferase activity" EXACT [EC:2.3.1.9]
synonym: "acetyl-CoA:N-acetyltransferase activity" EXACT [EC:2.3.1.9]
synonym: "beta-acetoacetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9]
synonym: "thiolase II" RELATED [EC:2.3.1.9]
xref: EC:2.3.1.9
xref: MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN
xref: UM-BBD_enzymeID:e0144
is_a: GO:0016453 ! C-acetyltransferase activity

[Term]
id: GO:0003986
name: acetyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + H2O = CoA + acetate." [EC:3.1.2.1]
subset: gosubset_prok
synonym: "acetyl coenzyme A acylase activity" EXACT [EC:3.1.2.1]
synonym: "acetyl coenzyme A deacylase activity" EXACT [EC:3.1.2.1]
synonym: "acetyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.1]
synonym: "acetyl-CoA acylase activity" EXACT [EC:3.1.2.1]
synonym: "acetyl-CoA deacylase activity" EXACT [EC:3.1.2.1]
synonym: "acetyl-CoA thiol esterase activity" EXACT [EC:3.1.2.1]
xref: EC:3.1.2.1
xref: MetaCyc:ACETYL-COA-HYDROLASE-RXN
xref: Reactome:12713 "acetyl-CoA hydrolase activity"
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0003987
name: acetate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA." [EC:6.2.1.1]
subset: gosubset_prok
synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.1]
synonym: "acetate to acetyl-CoA" RELATED []
synonym: "acetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.1]
synonym: "acetic thiokinase activity" EXACT [EC:6.2.1.1]
synonym: "acetyl activating enzyme" RELATED [EC:6.2.1.1]
synonym: "acetyl CoA ligase activity" EXACT [EC:6.2.1.1]
synonym: "acetyl CoA synthase activity" EXACT [EC:6.2.1.1]
synonym: "acetyl coenzyme A synthetase activity" EXACT [EC:6.2.1.1]
synonym: "acetyl-activating enzyme activity" EXACT [EC:6.2.1.1]
synonym: "acetyl-CoA synthase activity" EXACT [EC:6.2.1.1]
synonym: "acetyl-CoA synthetase activity" EXACT [EC:6.2.1.1]
synonym: "acetyl-coenzyme A synthase activity" EXACT [EC:6.2.1.1]
synonym: "ACS" RELATED [EC:6.2.1.1]
synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.1]
synonym: "short chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.1]
synonym: "short-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.1]
xref: EC:6.2.1.1
xref: MetaCyc:ACETATE--COA-LIGASE-RXN
xref: Reactome:12714 "acetate-CoA ligase activity"
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0003988
name: acetyl-CoA C-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [EC:2.3.1.16]
subset: gosubset_prok
synonym: "2-keto-acyl thiolase activity" EXACT []
synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.16]
synonym: "3-ketoacyl CoA thiolase activity" EXACT [EC:2.3.1.16]
synonym: "3-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
synonym: "3-ketoacyl thiolase activity" EXACT [EC:2.3.1.16]
synonym: "3-ketoacyl-CoA thiolase activity" EXACT []
synonym: "3-ketothiolase activity" EXACT [EC:2.3.1.16]
synonym: "3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
synonym: "3-oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
synonym: "6-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
synonym: "acetoacetyl-CoA beta-ketothiolase activity" EXACT [EC:2.3.1.16]
synonym: "acetyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16]
synonym: "acyl-CoA:acetyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.16]
synonym: "beta-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
synonym: "beta-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
synonym: "beta-ketoadipyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
synonym: "beta-ketoadipyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
synonym: "beta-ketothiolase activity" EXACT [EC:2.3.1.16]
synonym: "KAT" RELATED [EC:2.3.1.16]
synonym: "ketoacyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16]
synonym: "ketoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
synonym: "long-chain 3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
synonym: "oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16]
synonym: "pro-3-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16]
synonym: "thiolase I" RELATED [EC:2.3.1.16]
xref: EC:2.3.1.16
xref: MetaCyc:KETOACYLCOATHIOL-RXN
xref: Reactome:12715 "acetyl-CoA C-acyltransferase activity"
xref: UM-BBD_enzymeID:e0653
is_a: GO:0016408 ! C-acyltransferase activity

[Term]
id: GO:0003989
name: acetyl-CoA carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2]
subset: gosubset_prok
synonym: "acetyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.2]
synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.2]
xref: EC:6.4.1.2
xref: MetaCyc:ACETYL-COA-CARBOXYLTRANSFER-RXN
xref: Reactome:12716 "acetyl-CoA carboxylase activity"
is_a: GO:0016421 ! CoA carboxylase activity

[Term]
id: GO:0003990
name: acetylcholinesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7]
subset: gosubset_prok
synonym: "AcCholE" RELATED [EC:3.1.1.7]
synonym: "acetyl.beta-methylcholinesterase activity" EXACT [EC:3.1.1.7]
synonym: "acetylcholine acetylhydrolase activity" EXACT [EC:3.1.1.7]
synonym: "acetylcholine hydrolase activity" EXACT [EC:3.1.1.7]
synonym: "acetylthiocholinesterase activity" EXACT [EC:3.1.1.7]
synonym: "choline esterase I activity" EXACT [EC:3.1.1.7]
synonym: "true cholinesterase activity" EXACT [EC:3.1.1.7]
xref: EC:3.1.1.7
xref: MetaCyc:ACETYLCHOLINESTERASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0003991
name: acetylglutamate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate." [EC:2.7.2.8]
subset: gosubset_prok
synonym: "acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8]
synonym: "ATP:N-acetyl-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8]
synonym: "N-acetylglutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8]
synonym: "N-acetylglutamate kinase activity" EXACT [EC:2.7.2.8]
synonym: "N-acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8]
synonym: "N-acetylglutamic 5-phosphotransferase activity" EXACT [EC:2.7.2.8]
xref: EC:2.7.2.8
xref: MetaCyc:ACETYLGLUTKIN-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0003992
name: N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
namespace: molecular_function
alt_id: GO:0047318
def: "Catalysis of the reaction: N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.11]
subset: gosubset_prok
synonym: "2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.11]
synonym: "acetylornithine 5-aminotransferase activity" EXACT [EC:2.6.1.11]
synonym: "acetylornithine aminotransferase activity" BROAD []
synonym: "acetylornithine delta-transaminase activity" EXACT [EC:2.6.1.11]
synonym: "acetylornithine transaminase activity" BROAD [EC:2.6.1.11]
synonym: "ACOAT activity" EXACT [EC:2.6.1.11]
synonym: "N(2)-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11]
synonym: "N-acetylornithine aminotransferase activity" EXACT [EC:2.6.1.11]
synonym: "N-acetylornithine-delta-transaminase activity" EXACT [EC:2.6.1.11]
synonym: "N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.11]
synonym: "N2-acetylornithine 5-aminotransferase activity" EXACT []
synonym: "N2-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11]
synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.11]
xref: EC:2.6.1.11
xref: MetaCyc:ACETYLORNTRANSAM-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0003993
name: acid phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]
subset: gosubset_prok
synonym: "acid monophosphatase activity" EXACT [EC:3.1.3.2]
synonym: "acid nucleoside diphosphate phosphatase activity" EXACT [EC:3.1.3.2]
synonym: "acid phosphohydrolase activity" EXACT [EC:3.1.3.2]
synonym: "acid phosphomonoester hydrolase activity" EXACT [EC:3.1.3.2]
synonym: "acid phosphomonoesterase activity" EXACT [EC:3.1.3.2]
synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.2]
synonym: "orthophosphoric-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2]
synonym: "phosphate-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2]
synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.2]
synonym: "uteroferrin" RELATED [EC:3.1.3.2]
xref: EC:3.1.3.2
xref: MetaCyc:ACID-PHOSPHATASE-RXN
xref: Reactome:9271 "acid phosphatase activity"
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0003994
name: aconitate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: citrate = cis-aconitate + H2O = isocitrate; i.e. the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3]
subset: gosubset_prok
synonym: "aconitase activity" EXACT []
synonym: "cis-aconitase activity" EXACT [EC:4.2.1.3]
synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3]
synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [EC:4.2.1.3]
synonym: "citrate(isocitrate) hydro-lyase activity" EXACT [EC:4.2.1.3]
xref: EC:4.2.1.3
xref: MetaCyc:ACONITATEDEHYDR-RXN
xref: Reactome:12740 "aconitate hydratase activity"
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0003995
name: acyl-CoA dehydrogenase activity
namespace: molecular_function
alt_id: GO:0019109
def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]
subset: gosubset_prok
synonym: "acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3]
synonym: "acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3]
synonym: "acyl dehydrogenase activity" EXACT [EC:1.3.99.3]
synonym: "acyl-CoA reductase activity" EXACT [GOC:mah]
synonym: "acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3]
synonym: "acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3]
synonym: "fatty acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3]
synonym: "fatty-acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3]
synonym: "general acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3]
synonym: "long-chain acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3]
synonym: "long-chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3]
synonym: "medium-chain acyl-CoA dehydrogenase activity" NARROW [EC:1.3.99.3]
synonym: "medium-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3]
xref: EC:1.3.99.-
xref: EC:1.3.99.3
xref: MetaCyc:ACYLCOADEHYDROG-RXN
xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN
xref: Reactome:4266 "acyl-CoA dehydrogenase activity"
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0003996
name: acyl-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acyl + ATP + CoASH = AMP + diphosphate + acyl-CoA." [GOC:mah]
subset: gosubset_prok
xref: EC:6.2.1.-
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0003997
name: acyl-CoA oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2." [EC:1.3.3.6]
subset: gosubset_prok
synonym: "acyl coenzyme A oxidase activity" EXACT [EC:1.3.3.6]
synonym: "acyl-CoA:oxygen 2-oxidoreductase activity" EXACT [EC:1.3.3.6]
synonym: "fatty acyl-CoA oxidase activity" EXACT [EC:1.3.3.6]
synonym: "fatty acyl-coenzyme A oxidase activity" EXACT [EC:1.3.3.6]
xref: EC:1.3.3.6
xref: MetaCyc:ACYL-COA-OXIDASE-RXN
xref: Reactome:12745 "acyl-CoA oxidase activity"
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0003998
name: acylphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate." [EC:3.6.1.7]
subset: gosubset_prok
synonym: "1,3-diphosphoglycerate phosphatase activity" EXACT [EC:3.6.1.7]
synonym: "acetic phosphatase activity" EXACT [EC:3.6.1.7]
synonym: "acetylphosphatase activity" EXACT [EC:3.6.1.7]
synonym: "acylphosphate phosphohydrolase activity" EXACT [EC:3.6.1.7]
synonym: "GP 1-3" RELATED [EC:3.6.1.7]
synonym: "Ho 1-3" RELATED [EC:3.6.1.7]
xref: EC:3.6.1.7
xref: MetaCyc:ACYLPHOSPHATASE-RXN
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0003999
name: adenine phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.7]
subset: gosubset_prok
synonym: "adenine phosphoribosylpyrophosphate transferase activity" EXACT [EC:2.4.2.7]
synonym: "adenosine phosphoribosyltransferase activity" EXACT [EC:2.4.2.7]
synonym: "adenylate pyrophosphorylase activity" EXACT [EC:2.4.2.7]
synonym: "adenylic pyrophosphorylase activity" EXACT [EC:2.4.2.7]
synonym: "AMP diphosphorylase activity" EXACT [EC:2.4.2.7]
synonym: "AMP pyrophosphorylase activity" EXACT [EC:2.4.2.7]
synonym: "AMP-pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.7]
synonym: "AMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.7]
synonym: "APRT activity" EXACT [EC:2.4.2.7]
synonym: "transphosphoribosidase activity" RELATED [EC:2.4.2.7]
xref: EC:2.4.2.7
xref: MetaCyc:ADENPRIBOSYLTRAN-RXN
xref: Reactome:12749 "adenine phosphoribosyltransferase activity"
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004000
name: adenosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4]
subset: gosubset_prok
synonym: "adenosine aminohydrolase activity" EXACT [EC:3.5.4.4]
synonym: "adenosine deaminase reaction" EXACT []
xref: EC:3.5.4.4
xref: MetaCyc:ADENODEAMIN-RXN
xref: Reactome:6985 "adenosine deaminase activity"
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004001
name: adenosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + adenosine = ADP + AMP." [EC:2.7.1.20, PMID:11223943]
subset: gosubset_prok
synonym: "adenosine 5-phosphotransferase activity" EXACT []
synonym: "adenosine kinase (phosphorylating)" EXACT [EC:2.7.1.20]
synonym: "ATP:adenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.20]
xref: EC:2.7.1.20
xref: MetaCyc:ADENOSINE-KINASE-RXN
xref: Reactome:6989 "adenosine kinase activity"
is_a: GO:0019206 ! nucleoside kinase activity

[Term]
id: GO:0004003
name: ATP-dependent DNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
is_a: GO:0003678 ! DNA helicase activity
is_a: GO:0008026 ! ATP-dependent helicase activity
is_a: GO:0008094 ! DNA-dependent ATPase activity

[Term]
id: GO:0004004
name: ATP-dependent RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
is_a: GO:0003724 ! RNA helicase activity
is_a: GO:0008026 ! ATP-dependent helicase activity
is_a: GO:0008186 ! RNA-dependent ATPase activity

[Term]
id: GO:0004005
name: plasma membrane cation-transporting ATPase
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
is_obsolete: true
consider: GO:0005886
consider: GO:0019829

[Term]
id: GO:0004007
name: heavy metal-exporting ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate." [GOC:ai]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
is_obsolete: true
consider: GO:0046873

[Term]
id: GO:0004008
name: copper-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out)." [EC:3.6.3.4]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (Cu2+-exporting)" EXACT [EC:3.6.3.4]
synonym: "copper exporting ATPase activity" EXACT []
synonym: "copper-translocating P-type ATPase activity" RELATED [EC:3.6.3.4]
synonym: "Cu(2+)-exporting ATPase activity" EXACT [EC:3.6.3.4]
synonym: "Cu2+-exporting ATPase activity" EXACT [EC:3.6.3.4]
synonym: "cu2+-exporting ATPase activity" EXACT [EC:3.6.3.4]
xref: EC:3.6.3.4
xref: MetaCyc:3.6.3.4-RXN
is_a: GO:0043682 ! copper-transporting ATPase activity

[Term]
id: GO:0004009
name: ATP-binding cassette (ABC) transporter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping.
is_obsolete: true
consider: GO:0042626
consider: GO:0043190

[Term]
id: GO:0004012
name: phospholipid-translocating ATPase activity
namespace: molecular_function
alt_id: GO:0008557
def: "Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "aminophospholipid-transporting ATPase" NARROW []
synonym: "ATP phosphohydrolase (phospholipid-flipping)" EXACT [EC:3.6.3.1]
synonym: "flippase activity" BROAD [EC:3.6.3.1]
synonym: "magnesium-ATPase activity" RELATED [EC:3.6.3.1]
synonym: "Mg(2+)-ATPase activity" RELATED [EC:3.6.3.1]
synonym: "Mg2+-ATPase activity" EXACT [EC:3.6.3.1]
synonym: "phospholipid translocating ATPase activity" EXACT []
synonym: "phospholipid-transporting ATPase activity" EXACT [EC:3.6.3.1]
xref: EC:3.6.3.1
xref: MetaCyc:3.6.3.1-RXN
is_a: GO:0015247 ! aminophospholipid transporter activity
is_a: GO:0043492 ! ATPase activity, coupled to movement of substances

[Term]
id: GO:0004013
name: adenosylhomocysteinase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1]
subset: gosubset_prok
synonym: "adenosylhomocysteine hydrolase activity" EXACT [EC:3.3.1.1]
synonym: "AdoHcyase activity" EXACT [EC:3.3.1.1]
synonym: "S-adenosyl-L-homocysteine hydrolase activity" EXACT [EC:3.3.1.1]
synonym: "S-adenosylhomocysteinase activity" EXACT [EC:3.3.1.1]
synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.3.1.1]
synonym: "S-adenosylhomocysteine synthase activity" EXACT [EC:3.3.1.1]
synonym: "SAHase activity" EXACT [EC:3.3.1.1]
xref: EC:3.3.1.1
xref: MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN
xref: Reactome:7047 "adenosylhomocysteinase activity"
is_a: GO:0016802 ! trialkylsulfonium hydrolase activity

[Term]
id: GO:0004014
name: adenosylmethionine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine = (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt + CO2." [EC:4.1.1.50]
subset: gosubset_prok
synonym: "adenosyl methionine decarboxylase activity" EXACT []
synonym: "S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]" RELATED [EC:4.1.1.50]
synonym: "S-adenosyl-L-methionine carboxy-lyase activity" EXACT [EC:4.1.1.50]
synonym: "S-adenosyl-L-methionine decarboxylase activity" EXACT [EC:4.1.1.50]
synonym: "S-adenosylmethionine decarboxylase activity" EXACT [EC:4.1.1.50]
xref: EC:4.1.1.50
xref: MetaCyc:SAMDECARB-RXN
xref: Reactome:7049 "adenosylmethionine decarboxylase activity"
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004015
name: adenosylmethionine-8-amino-7-oxononanoate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate." [EC:2.6.1.62]
subset: gosubset_prok
synonym: "7,8-diamino-pelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62]
synonym: "7,8-diaminonanoate transaminase activity" EXACT [EC:2.6.1.62]
synonym: "7,8-diaminononanoate aminotransferase activity" EXACT [EC:2.6.1.62]
synonym: "7,8-diaminononanoate transaminase activity" EXACT [EC:2.6.1.62]
synonym: "7,8-diaminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62]
synonym: "7-keto-8-aminopelargonic acid" RELATED [EC:2.6.1.62]
synonym: "7-keto-8-aminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62]
synonym: "adenosyl methionine-8-amino-7-oxononanoate transaminase activity" EXACT []
synonym: "adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62]
synonym: "adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity" EXACT []
synonym: "DAPA aminotransferase activity" EXACT [EC:2.6.1.62]
synonym: "DAPA transaminase activity" EXACT [EC:2.6.1.62]
synonym: "diaminopelargonate synthase activity" EXACT [EC:2.6.1.62]
synonym: "S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62]
xref: EC:2.6.1.62
xref: MetaCyc:DAPASYN-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004016
name: adenylate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1]
subset: gosubset_prok
synonym: "3',5'-cyclic AMP synthetase activity" EXACT [EC:4.6.1.1]
synonym: "adenyl cyclase activity" EXACT [EC:4.6.1.1]
synonym: "adenylyl cyclase activity" EXACT []
synonym: "adenylylcyclase activity" EXACT [EC:4.6.1.1]
synonym: "ATP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.1]
synonym: "ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity" EXACT [EC:4.6.1.1]
synonym: "ATP pyrophosphate-lyase activity" EXACT [EC:4.6.1.1]
synonym: "cAMP generating peptide activity" RELATED []
xref: EC:4.6.1.1
xref: MetaCyc:ADENYLATECYC-RXN
xref: Reactome:7056 "adenylate cyclase activity"
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0004017
name: adenylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3]
subset: gosubset_prok
synonym: "5'-AMP-kinase activity" EXACT [EC:2.7.4.3]
synonym: "adenylic kinase activity" EXACT [EC:2.7.4.3]
synonym: "adenylokinase activity" EXACT [EC:2.7.4.3]
synonym: "ATP:AMP phosphotransferase activity" EXACT [EC:2.7.4.3]
synonym: "myokinase activity" NARROW [EC:2.7.4.3]
xref: EC:2.7.4.3
xref: MetaCyc:ADENYL-KIN-RXN
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019201 ! nucleotide kinase activity

[Term]
id: GO:0004018
name: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP." [EC:4.3.2.2]
subset: gosubset_prok
synonym: "6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2]
synonym: "adenylosuccinase activity" BROAD [EC:4.3.2.2, GOC:mah]
synonym: "adenylosuccinate lyase activity" BROAD [GOC:mah]
synonym: "N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2]
synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah]
xref: EC:4.3.2.2
xref: KEGG:R01083
xref: MetaCyc:AMPSYN-RXN
xref: Reactome:7065 "N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0004019
name: adenylosuccinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP." [EC:6.3.4.4]
subset: gosubset_prok
synonym: "adenylosuccinate synthetase activity" EXACT [EC:6.3.4.4]
synonym: "IMP--aspartate ligase activity" EXACT [EC:6.3.4.4]
synonym: "IMP:L-aspartate ligase (GDP-forming)" EXACT [EC:6.3.4.4]
synonym: "succino-AMP synthetase activity" EXACT [EC:6.3.4.4]
synonym: "succinoadenylic kinosynthetase activity" EXACT [EC:6.3.4.4]
xref: EC:6.3.4.4
xref: MetaCyc:ADENYLOSUCCINATE-SYNTHASE-RXN
xref: Reactome:7069 "adenylosuccinate synthase activity"
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004020
name: adenylylsulfate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate." [EC:2.7.1.25]
subset: gosubset_prok
synonym: "5'-phosphoadenosine sulfate kinase activity" EXACT [EC:2.7.1.25]
synonym: "adenosine 5'-phosphosulfate kinase activity" EXACT [EC:2.7.1.25]
synonym: "adenosine phosphosulfate kinase activity" EXACT [EC:2.7.1.25]
synonym: "adenosine phosphosulfokinase activity" EXACT [EC:2.7.1.25]
synonym: "adenosine-5'-phosphosulfate 3'-phosphotransferase activity" EXACT []
synonym: "adenosine-5'-phosphosulfate-3'-phosphokinase activity" EXACT [EC:2.7.1.25]
synonym: "adenosine-5'-phosphosulphate 3'-phosphotransferase activity" EXACT []
synonym: "adenylyl-sulfate kinase activity" EXACT []
synonym: "adenylyl-sulphate kinase activity" EXACT []
synonym: "adenylylsulfate kinase (phosphorylating)" EXACT [EC:2.7.1.25]
synonym: "APS kinase activity" EXACT [EC:2.7.1.25]
synonym: "ATP:adenylyl-sulfate 3'-phosphotransferase activity" EXACT [EC:2.7.1.25]
xref: EC:2.7.1.25
xref: MetaCyc:ADENYLYLSULFKIN-RXN
xref: Reactome:7077 "adenylylsulfate kinase activity"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004021
name: L-alanine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate." [EC:2.6.1.2]
subset: gosubset_prok
synonym: "alanine aminotransferase activity" BROAD []
synonym: "alanine transaminase activity" BROAD [EC:2.6.1.2]
synonym: "alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2]
synonym: "alanine-pyruvate aminotransferase activity" EXACT [EC:2.6.1.2]
synonym: "ALT" RELATED [EC:2.6.1.2]
synonym: "beta-alanine aminotransferase" BROAD [EC:2.6.1.2]
synonym: "glutamic acid-pyruvic acid transaminase activity" EXACT [EC:2.6.1.2]
synonym: "glutamic--alanine transaminase activity" EXACT [EC:2.6.1.2]
synonym: "glutamic--pyruvic transaminase activity" EXACT [EC:2.6.1.2]
synonym: "glutamic-pyruvic aminotransferase activity" EXACT [EC:2.6.1.2]
synonym: "GPT" RELATED [EC:2.6.1.2]
synonym: "L-alanine aminotransferase activity" BROAD [EC:2.6.1.2]
synonym: "L-alanine transaminase activity" BROAD [EC:2.6.1.2]
synonym: "L-alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2]
synonym: "pyruvate transaminase activity" BROAD [EC:2.6.1.2]
synonym: "pyruvate-alanine aminotransferase activity" EXACT [EC:2.6.1.2]
synonym: "pyruvate-glutamate transaminase activity" EXACT [EC:2.6.1.2]
xref: EC:2.6.1.2
xref: MetaCyc:ALANINE-AMINOTRANSFERASE-RXN
xref: Reactome:7079 "L-alanine:2-oxoglutarate aminotransferase activity"
is_a: GO:0047635 ! alanine-oxo-acid transaminase activity

[Term]
id: GO:0004022
name: alcohol dehydrogenase (NAD) activity
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1]
subset: gosubset_prok
synonym: "ADH" RELATED [EC:1.1.1.1]
synonym: "alcohol dehydrogenase activity" BROAD [GOC:mah]
synonym: "alcohol:NAD+ oxidoreductase" EXACT [EC:1.1.1.1]
synonym: "aliphatic alcohol dehydrogenase" NARROW [EC:1.1.1.1]
synonym: "ethanol dehydrogenase" NARROW [EC:1.1.1.1]
synonym: "NAD-dependent alcohol dehydrogenase" EXACT [EC:1.1.1.1]
synonym: "NAD-specific aromatic alcohol dehydrogenase" EXACT [EC:1.1.1.1]
synonym: "NADH-alcohol dehydrogenase" EXACT [EC:1.1.1.1]
synonym: "NADH-aldehyde dehydrogenase" EXACT [EC:1.1.1.1]
synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.1.1]
synonym: "yeast alcohol dehydrogenase" NARROW [EC:1.1.1.1]
xref: EC:1.1.1.1
xref: MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN
xref: UM-BBD_enzymeID:e0023
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004023
name: alcohol dehydrogenase activity, metal ion-independent
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion." [EC:1.1.1.1, GOC:mah]
is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity

[Term]
id: GO:0004024
name: alcohol dehydrogenase activity, zinc-dependent
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ requiring the presence of zinc." [EC:1.1.1.1, GOC:mah]
subset: gosubset_prok
xref: Reactome:7085 "alcohol dehydrogenase activity, zinc-dependent"
is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity

[Term]
id: GO:0004025
name: alcohol dehydrogenase activity, iron-dependent
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron." [EC:1.1.1.1, GOC:mah]
subset: gosubset_prok
is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity

[Term]
id: GO:0004026
name: alcohol O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester." [EC:2.3.1.84]
synonym: "AATASE activity" EXACT [EC:2.3.1.84]
synonym: "acetyl-CoA:alcohol O-acetyltransferase activity" EXACT [EC:2.3.1.84]
synonym: "alcohol acetyltransferase activity" EXACT [EC:2.3.1.84]
xref: EC:2.3.1.84
xref: MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN
is_a: GO:0016413 ! O-acetyltransferase activity
is_a: GO:0034318 ! alcohol O-acyltransferase activity

[Term]
id: GO:0004027
name: alcohol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2]
subset: gosubset_prok
synonym: "3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity" EXACT [EC:2.8.2.2]
synonym: "3-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2]
synonym: "3beta-hydroxy steroid sulfotransferase activity" EXACT [EC:2.8.2.2]
synonym: "3beta-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2]
synonym: "5alpha-androstenol sulfotransferase activity" EXACT [EC:2.8.2.2]
synonym: "alcohol sulphotransferase activity" EXACT []
synonym: "alcohol/hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2]
synonym: "dehydroepiandrosterone sulfotransferase activity" EXACT [EC:2.8.2.2]
synonym: "delta5-3beta-hydroxysteroid sulfokinase activity" EXACT [EC:2.8.2.2]
synonym: "estrogen sulfokinase activity" EXACT [EC:2.8.2.2]
synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.2]
synonym: "HST" RELATED [EC:2.8.2.2]
synonym: "hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2]
synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.2]
synonym: "steroid sulfokinase activity" EXACT [EC:2.8.2.2]
synonym: "sterol sulfokinase activity" EXACT [EC:2.8.2.2]
synonym: "sterol sulfotransferase activity" EXACT [EC:2.8.2.2]
xref: EC:2.8.2.2
xref: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN
xref: Reactome:7092 "alcohol sulfotransferase activity"
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0004028
name: 3-chloroallyl aldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid." [UM-BBD_enzymeID:e0432]
subset: gosubset_prok
xref: EC:1.2.1.-
xref: Reactome:7095 "3-chloroallyl aldehyde dehydrogenase activity"
xref: UM-BBD_enzymeID:e0432
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004029
name: aldehyde dehydrogenase (NAD) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3]
subset: gosubset_prok
synonym: "aldehyde dehydrogenase (NAD+)" EXACT [EC:1.2.1.3]
synonym: "aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.3]
synonym: "CoA-independent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3]
synonym: "m-methylbenzaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3]
synonym: "NAD-aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3]
synonym: "NAD-dependent 4-hydroxynonenal dehydrogenase activity" EXACT [EC:1.2.1.3]
synonym: "NAD-dependent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3]
synonym: "NAD-linked aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3]
synonym: "propionaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3]
xref: EC:1.2.1.3
xref: MetaCyc:ALDHDEHYDROG-RXN
xref: Reactome:7097 "aldehyde dehydrogenase (NAD) activity"
xref: UM-BBD_enzymeID:e0024
xref: Wikipedia:Aldehyde_dehydrogenase_(NAD+)
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004030
name: aldehyde dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+." [EC:1.2.1.5]
subset: gosubset_prok
synonym: "aldehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.5]
synonym: "ALDH" RELATED [EC:1.2.1.5]
xref: EC:1.2.1.5
xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004031
name: aldehyde oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + H2O2." [EC:1.2.3.1]
subset: gosubset_prok
synonym: "aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.1]
synonym: "quinoline oxidase activity" RELATED [EC:1.2.3.1]
xref: EC:1.2.3.1
xref: MetaCyc:ALDEHYDE-OXIDASE-RXN
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0004032
name: aldehyde reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21]
subset: gosubset_prok
synonym: "aldose reductase activity" EXACT [EC:1.1.1.21]
synonym: "polyol dehydrogenase (NADP(+)) activity" RELATED [EC:1.1.1.21]
xref: EC:1.1.1.21
xref: MetaCyc:ALDEHYDE-REDUCTASE-RXN
xref: Reactome:7111 "aldehyde reductase activity"
is_a: GO:0004033 ! aldo-keto reductase activity

[Term]
id: GO:0004033
name: aldo-keto reductase activity
namespace: molecular_function
def: "Catalysis of the NADPH-dependent reduction of carbonyl compounds." [GOC:jl, PMID:2498333]
subset: gosubset_prok
synonym: "NADPH-dependent aldo-keto reductase activity" EXACT [GOC:vw]
xref: EC:1.1.1.-
xref: Reactome:7114 "aldo-keto reductase activity"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004034
name: aldose 1-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose." [EC:5.1.3.3]
subset: gosubset_prok
synonym: "aldose mutarotase activity" RELATED [EC:5.1.3.3]
synonym: "mutarotase activity" RELATED [EC:5.1.3.3]
xref: EC:5.1.3.3
xref: MetaCyc:ALDOSE-1-EPIMERASE-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0004035
name: alkaline phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1]
subset: gosubset_prok
synonym: "alkaline phenyl phosphatase activity" EXACT [EC:3.1.3.1]
synonym: "alkaline phosphohydrolase activity" EXACT [EC:3.1.3.1]
synonym: "alkaline phosphomonoesterase activity" EXACT [EC:3.1.3.1]
synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.1]
synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1]
synonym: "phosphate-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1]
synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.1]
xref: EC:3.1.3.1
xref: MetaCyc:ALKAPHOSPHA-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0004037
name: allantoicase activity
namespace: molecular_function
def: "Catalysis of the reaction: allantoate + H2O = (-)-ureidoglycolate + urea." [EC:3.5.3.4]
subset: gosubset_prok
synonym: "allantoate amidinohydrolase activity" EXACT [EC:3.5.3.4]
synonym: "allantoine amidinohydrolase activity" EXACT []
xref: EC:3.5.3.4
xref: MetaCyc:ALLANTOICASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0004038
name: allantoinase activity
namespace: molecular_function
def: "Catalysis of the reaction: allantoin + H2O = allantoate." [EC:3.5.2.5]
subset: gosubset_prok
synonym: "(S)-allantoin amidohydrolase activity" EXACT [EC:3.5.2.5]
xref: EC:3.5.2.5
xref: MetaCyc:ALLANTOINASE-RXN
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0004039
name: allophanate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: urea-1-carboxylate + H2O = 2 CO2 + 2 NH3." [EC:3.5.1.54]
subset: gosubset_prok
synonym: "allophanate lyase activity" EXACT [EC:3.5.1.54]
synonym: "urea-1-carboxylate amidohydrolase activity" EXACT [EC:3.5.1.54]
xref: EC:3.5.1.54
xref: MetaCyc:ALLOPHANATE-HYDROLASE-RXN
xref: UM-BBD_enzymeID:e0534
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004040
name: amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4]
subset: gosubset_prok
synonym: "acetamidase activity" EXACT []
synonym: "acylamidase activity" EXACT [EC:3.5.1.4]
synonym: "acylamide amidohydrolase activity" EXACT [EC:3.5.1.4]
synonym: "acylase activity" EXACT [EC:3.5.1.4]
synonym: "amidohydrolase activity" EXACT [EC:3.5.1.4]
synonym: "fatty acylamidase activity" EXACT [EC:3.5.1.4]
synonym: "N-acetylaminohydrolase activity" EXACT [EC:3.5.1.4]
xref: EC:3.5.1.4
xref: MetaCyc:AMIDASE-RXN
xref: UM-BBD_enzymeID:e0068
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004042
name: acetyl-CoA:L-glutamate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate." [EC:2.3.1.1]
subset: gosubset_prok
synonym: "acetylglutamate acetylglutamate synthetase activity" EXACT [EC:2.3.1.1]
synonym: "AGAS" RELATED [EC:2.3.1.1]
synonym: "amino acid acetyltransferase activity" EXACT [EC:2.3.1.1]
synonym: "amino-acid N-acetyltransferase activity" BROAD [EC:2.3.1.1]
synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.1]
xref: EC:2.3.1.1
xref: MetaCyc:N-ACETYLTRANSFER-RXN
xref: Reactome:7143 "amino-acid N-acetyltransferase activity"
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004043
name: L-aminoadipate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31]
subset: gosubset_prok
synonym: "2-aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31]
synonym: "2-aminoadipic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31]
synonym: "AAR" EXACT [EC:1.2.1.31]
synonym: "alpha-aminoadipate reductase activity" EXACT [EC:1.2.1.31]
synonym: "alpha-aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31]
synonym: "aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31]
synonym: "aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31]
synonym: "L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase" EXACT [EC:1.2.1.31]
synonym: "L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity" EXACT [EC:1.2.1.31]
synonym: "L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.31]
synonym: "L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity" EXACT [EC:1.2.1.31]
xref: EC:1.2.1.31
xref: MetaCyc:1.2.1.31-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004044
name: amidophosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O." [EC:2.4.2.14]
subset: gosubset_prok
synonym: "5'-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)" EXACT [EC:2.4.2.14]
synonym: "5-phosphororibosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "glutamine 5-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "glutamine phosphoribosyldiphosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "glutamine phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "phosphoribose pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "phosphoribosyl pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "phosphoribosyldiphosphate 5-amidotransferase activity" EXACT [EC:2.4.2.14]
synonym: "phosphoribosylpyrophosphate glutamyl amidotransferase activity" EXACT [EC:2.4.2.14]
xref: EC:2.4.2.14
xref: MetaCyc:PRPPAMIDOTRANS-RXN
xref: Reactome:7147 "amidophosphoribosyltransferase activity"
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004045
name: aminoacyl-tRNA hydrolase activity
namespace: molecular_function
alt_id: GO:0019850
alt_id: GO:0019851
def: "Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29]
subset: gosubset_prok
synonym: "aminoacyl-transfer ribonucleate hydrolase activity" EXACT [EC:3.1.1.29]
synonym: "aminoacyl-tRNA aminoacylhydrolase activity" EXACT [EC:3.1.1.29]
synonym: "aminoacyl-tRNA hydrolase reaction" EXACT []
synonym: "D-tyrosyl-tRNA hydrolase activity" NARROW [PMID:15292242]
synonym: "N-substituted aminoacyl transfer RNA hydrolase activity" EXACT [EC:3.1.1.29]
synonym: "peptidyl-tRNA hydrolase activity" EXACT [EC:3.1.1.29]
xref: EC:3.1.1.29
xref: MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0004046
name: aminoacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14]
subset: gosubset_prok
synonym: "acylase I activity" NARROW [EC:3.5.1.14]
synonym: "alpha-N-acylaminoacid hydrolase activity" EXACT [EC:3.5.1.14]
synonym: "amido acid deacylase activity" EXACT [EC:3.5.1.14]
synonym: "aminoacylase I activity" NARROW [EC:3.5.1.14]
synonym: "benzamidase activity" RELATED [EC:3.5.1.14]
synonym: "dehydropeptidase II activity" NARROW [EC:3.5.1.14]
synonym: "hippurase activity" EXACT [EC:3.5.1.14]
synonym: "histozyme activity" RELATED [EC:3.5.1.14]
synonym: "L-amino-acid acylase activity" EXACT [EC:3.5.1.14]
synonym: "L-aminoacylase activity" EXACT [EC:3.5.1.14]
synonym: "long acyl amidoacylase activity" EXACT [EC:3.5.1.14]
synonym: "N-acyl-L-amino-acid amidohydrolase activity" EXACT [EC:3.5.1.14]
synonym: "short acyl amidoacylase activity" EXACT [EC:3.5.1.14]
xref: EC:3.5.1.14
xref: MetaCyc:AMINOACYLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004047
name: aminomethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10]
subset: gosubset_prok
synonym: "glycine synthase activity" RELATED [EC:2.1.2.10]
synonym: "glycine-cleavage system T-protein activity" RELATED [EC:2.1.2.10]
synonym: "protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10]
synonym: "protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10]
synonym: "S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10]
synonym: "T-protein" RELATED [EC:2.1.2.10]
synonym: "tetrahydrofolate aminomethyltransferase activity" EXACT [EC:2.1.2.10]
xref: EC:2.1.2.10
xref: MetaCyc:GCVT-RXN
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0004048
name: anthranilate phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-a-D-ribose 1-diphosphate." [EC:2.4.2.18]
subset: gosubset_prok
synonym: "anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18]
synonym: "anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18]
synonym: "anthranilate-PP-ribose-P phosphoribosyltransferase activity" EXACT [EC:2.4.2.18]
synonym: "N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.18]
synonym: "phosphoribosyl-anthranilate diphosphorylase activity" EXACT [EC:2.4.2.18]
synonym: "phosphoribosyl-anthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18]
synonym: "phosphoribosylanthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18]
synonym: "phosphoribosylanthranilate transferase activity" EXACT [EC:2.4.2.18]
synonym: "PRT" RELATED [EC:2.4.2.18]
xref: EC:2.4.2.18
xref: MetaCyc:PRTRANS-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004049
name: anthranilate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate." [EC:4.1.3.27]
subset: gosubset_prok
synonym: "anthranilate synthetase activity" EXACT [EC:4.1.3.27]
synonym: "chorismate pyruvate-lyase (amino-accepting) activity" EXACT [EC:4.1.3.27]
xref: EC:4.1.3.27
xref: MetaCyc:ANTHRANSYN-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0004050
name: apyrase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate." [EC:3.6.1.5, MetaCyc:APYRASE-RXN]
comment: This term was made obsolete because it represents a gene product which can catalyze two reactions.
is_obsolete: true
consider: GO:0017110
consider: GO:0017111

[Term]
id: GO:0004051
name: arachidonate 5-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate." [EC:1.13.11.34]
subset: gosubset_prok
synonym: "5-delta-lipoxygenase activity" EXACT [EC:1.13.11.34]
synonym: "5-lipoxygenase activity" EXACT [EC:1.13.11.34]
synonym: "5Delta-lipoxygenase activity" EXACT [EC:1.13.11.34]
synonym: "arachidonate:oxygen 5-oxidoreductase activity" EXACT [EC:1.13.11.34]
synonym: "arachidonic 5-lipoxygenase activity" EXACT [EC:1.13.11.34]
synonym: "arachidonic acid 5-lipoxygenase activity" EXACT [EC:1.13.11.34]
synonym: "C-5-lipoxygenase activity" RELATED [EC:1.13.11.34]
synonym: "delta(5)-lipoxygenase activity" RELATED [EC:1.13.11.34]
synonym: "delta5-lipoxygenase activity" EXACT [EC:1.13.11.34]
synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.34]
synonym: "leukotriene-A(4) synthase activity" NARROW [EC:1.13.11.34]
synonym: "leukotriene-A4 synthase activity" EXACT [EC:1.13.11.34]
synonym: "LTA synthase activity" NARROW [EC:1.13.11.34]
xref: EC:1.13.11.34
xref: MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN
xref: Reactome:7163 "arachidonate 5-lipoxygenase activity"
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0004052
name: arachidonate 12-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate." [EC:1.13.11.31]
synonym: "12-lipoxygenase activity" RELATED [EC:1.13.11.31]
synonym: "12Delta-lipoxygenase activity" EXACT [EC:1.13.11.31]
synonym: "12S-lipoxygenase activity" EXACT [EC:1.13.11.31]
synonym: "arachidonate:oxygen 12-oxidoreductase activity" EXACT [EC:1.13.11.31]
synonym: "C-12 lipoxygenase activity" EXACT [EC:1.13.11.31]
synonym: "delta12-lipoxygenase activity" EXACT [EC:1.13.11.31]
synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.31]
synonym: "LTA4 synthase activity" EXACT [EC:1.13.11.31]
xref: EC:1.13.11.31
xref: MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0004053
name: arginase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea." [EC:3.5.3.1]
subset: gosubset_prok
synonym: "arginine amidinase activity" EXACT [EC:3.5.3.1]
synonym: "arginine transamidinase activity" EXACT [EC:3.5.3.1]
synonym: "canavanase activity" EXACT [EC:3.5.3.1]
synonym: "L-arginase activity" EXACT [EC:3.5.3.1]
synonym: "L-arginine amidinohydrolase activity" EXACT [EC:3.5.3.1]
xref: EC:3.5.3.1
xref: MetaCyc:ARGINASE-RXN
xref: Reactome:7167 "arginase activity"
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0004054
name: arginine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-arginine = ADP + N-phospho-L-arginine." [EC:2.7.3.3]
synonym: "adenosine 5'-triphosphate-arginine phosphotransferase activity" EXACT [EC:2.7.3.3]
synonym: "adenosine 5'-triphosphate:L-arginine" RELATED [EC:2.7.3.3]
synonym: "arginine phosphokinase activity" EXACT [EC:2.7.3.3]
synonym: "ATP:L-arginine N-phosphotransferase activity" EXACT [EC:2.7.3.3]
xref: EC:2.7.3.3
xref: MetaCyc:ARGININE-KINASE-RXN
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor
is_a: GO:0019202 ! amino acid kinase activity

[Term]
id: GO:0004055
name: argininosuccinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [EC:6.3.4.5]
subset: gosubset_prok
synonym: "arginine succinate synthetase activity" EXACT [EC:6.3.4.5]
synonym: "argininosuccinate synthetase activity" EXACT [EC:6.3.4.5]
synonym: "argininosuccinic acid synthetase activity" EXACT [EC:6.3.4.5]
synonym: "arginosuccinate synthetase activity" EXACT [EC:6.3.4.5]
synonym: "citrulline--aspartate ligase activity" EXACT [EC:6.3.4.5]
synonym: "L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [EC:6.3.4.5]
xref: EC:6.3.4.5
xref: MetaCyc:ARGSUCCINSYN-RXN
xref: Reactome:7171 "argininosuccinate synthase activity"
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004056
name: argininosuccinate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine." [EC:4.3.2.1]
subset: gosubset_prok
synonym: "2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1]
synonym: "2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1]
synonym: "arginine-succinate lyase activity" EXACT [EC:4.3.2.1]
synonym: "argininosuccinic acid lyase activity" EXACT [EC:4.3.2.1]
synonym: "arginosuccinase activity" EXACT [EC:4.3.2.1]
synonym: "N-(L-argininosuccinate) arginine-lyase activity" EXACT [EC:4.3.2.1]
synonym: "omega-N-(L-arginino)succinate arginine-lyase activity" EXACT [EC:4.3.2.1]
xref: EC:4.3.2.1
xref: MetaCyc:ARGSUCCINLYA-RXN
xref: Reactome:7173 "argininosuccinate lyase activity"
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0004057
name: arginyltransferase activity
namespace: molecular_function
alt_id: GO:0042172
def: "Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein." [EC:2.3.2.8]
subset: gosubset_prok
synonym: "arginine transferase activity" EXACT [EC:2.3.2.8]
synonym: "arginyl-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.8]
synonym: "arginyl-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.8]
synonym: "arginyl-tRNA protein transferase activity" EXACT [EC:2.3.2.8]
synonym: "arginyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.8]
synonym: "arginyl-tRNA-protein transferase activity" EXACT []
synonym: "L-arginyl-tRNA:protein arginyltransferase activity" EXACT [EC:2.3.2.8]
xref: EC:2.3.2.8
xref: MetaCyc:ARGINYLTRANSFERASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0004058
name: aromatic-L-amino-acid decarboxylase activity
namespace: molecular_function
alt_id: GO:0016400
def: "Catalysis of the reaction: L-tryptophan = tryptamine + CO2." [EC:4.1.1.28]
synonym: "5-hydroxytryptophan decarboxylase activity" EXACT [EC:4.1.1.28]
synonym: "aromatic amino acid decarboxylase activity" EXACT [EC:4.1.1.28]
synonym: "aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)" EXACT [EC:4.1.1.28]
synonym: "aromatic-L-amino-acid carboxy-lyase activity" EXACT [EC:4.1.1.28]
synonym: "DOPA decarboxylase activity" EXACT [EC:4.1.1.28]
synonym: "hydroxytryptophan decarboxylase activity" EXACT [EC:4.1.1.28]
synonym: "L-DOPA decarboxylase activity" EXACT [EC:4.1.1.28]
synonym: "tryptophan decarboxylase activity" EXACT [EC:4.1.1.28]
xref: EC:4.1.1.28
xref: MetaCyc:AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN
xref: Reactome:7178 "aromatic-L-amino-acid decarboxylase activity"
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004059
name: aralkylamine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." [EC:2.3.1.87]
synonym: "AANAT activity" EXACT [EC:2.3.1.87]
synonym: "acetyl-CoA:2-arylethylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87]
synonym: "arylalkylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87]
synonym: "melatonin rhythm enzyme activity" RELATED [EC:2.3.1.87]
synonym: "serotonin acetylase activity" NARROW [EC:2.3.1.87]
synonym: "serotonin acetyltransferase activity" NARROW [EC:2.3.1.87]
synonym: "serotonin N-acetyltransferase activity" NARROW [EC:2.3.1.87]
xref: EC:2.3.1.87
xref: MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN
xref: Reactome:7181 "aralkylamine N-acetyltransferase activity"
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004060
name: arylamine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine." [EC:2.3.1.5]
subset: gosubset_prok
synonym: "2-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5]
synonym: "4-aminobiphenyl N-acetyltransferase activity" EXACT [EC:2.3.1.5]
synonym: "acetyl CoA-arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5]
synonym: "acetyl-CoA:arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5]
synonym: "arylamine acetylase activity" EXACT [EC:2.3.1.5]
synonym: "arylamine acetyltransferase activity" EXACT [EC:2.3.1.5]
synonym: "beta-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5]
synonym: "indoleamine N-acetyltransferase activity" EXACT [EC:2.3.1.5]
synonym: "p-aminosalicylate N-acetyltransferase activity" EXACT [EC:2.3.1.5]
xref: EC:2.3.1.5
xref: MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN
xref: Reactome:7187 "arylamine N-acetyltransferase activity"
xref: UM-BBD_enzymeID:e0341
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004061
name: arylformamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [EC:3.5.1.9]
subset: gosubset_prok
synonym: "aryl-formylamine amidohydrolase activity" EXACT [EC:3.5.1.9]
synonym: "formamidase I" RELATED [EC:3.5.1.9]
synonym: "formamidase II" RELATED [EC:3.5.1.9]
synonym: "formylase activity" EXACT [EC:3.5.1.9]
synonym: "formylkynureninase activity" EXACT [EC:3.5.1.9]
synonym: "formylkynurenine formamidase activity" EXACT [EC:3.5.1.9]
synonym: "kynurenine formamidase activity" EXACT [EC:3.5.1.9]
xref: EC:3.5.1.9
xref: MetaCyc:ARYLFORMAMIDASE-RXN
xref: Reactome:7190 "arylformamidase activity"
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004062
name: aryl sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1]
subset: gosubset_prok
synonym: "1-naphthol phenol sulfotransferase activity" EXACT [EC:2.8.2.1]
synonym: "2-naphtholsulfotransferase activity" EXACT [EC:2.8.2.1]
synonym: "3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity" EXACT [EC:2.8.2.1]
synonym: "4-nitrocatechol sulfokinase activity" EXACT [EC:2.8.2.1]
synonym: "aryl sulphotransferase activity" EXACT []
synonym: "arylsulfotransferase" BROAD [EC:2.8.2.1]
synonym: "dopamine sulfotransferase activity" EXACT [EC:2.8.2.1]
synonym: "p-nitrophenol sulfotransferase activity" EXACT [EC:2.8.2.1]
synonym: "phenol sulfokinase activity" EXACT [EC:2.8.2.1]
synonym: "phenol sulfotransferase activity" EXACT [EC:2.8.2.1]
synonym: "PST" RELATED [EC:2.8.2.1]
synonym: "ritodrine sulfotransferase activity" EXACT [EC:2.8.2.1]
synonym: "sulfokinase activity" RELATED [EC:2.8.2.1]
xref: EC:2.8.2.1
xref: MetaCyc:ARYL-SULFOTRANSFERASE-RXN
xref: Reactome:7193 "aryl sulfotransferase activity"
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0004063
name: aryldialkylphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol." [EC:3.1.8.1]
subset: gosubset_prok
synonym: "A-esterase activity" BROAD [EC:3.1.8.1]
synonym: "aryltriphosphatase activity" EXACT [EC:3.1.8.1]
synonym: "aryltriphosphate dialkylphosphohydrolase activity" EXACT [EC:3.1.8.1]
synonym: "esterase B1" RELATED [EC:3.1.8.1]
synonym: "esterase E4" RELATED [EC:3.1.8.1]
synonym: "OPH" RELATED [EC:3.1.8.1]
synonym: "organophosphate esterase activity" EXACT [EC:3.1.8.1]
synonym: "organophosphate hydrolase activity" EXACT [EC:3.1.8.1]
synonym: "organophosphorus acid anhydrase activity" EXACT [EC:3.1.8.1]
synonym: "organophosphorus hydrolase activity" EXACT [EC:3.1.8.1]
synonym: "paraoxon esterase activity" EXACT [EC:3.1.8.1]
synonym: "paraoxon hydrolase activity" BROAD [EC:3.1.8.1]
synonym: "paraoxonase activity" BROAD [EC:3.1.8.1]
synonym: "phosphotriesterase activity" EXACT [EC:3.1.8.1]
synonym: "pirimiphos-methyloxon esterase activity" EXACT [EC:3.1.8.1]
xref: EC:3.1.8.1
xref: MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN
xref: UM-BBD_enzymeID:e0054
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0004064
name: arylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2]
subset: gosubset_prok
synonym: "A-esterase activity" BROAD [EC:3.1.1.2]
synonym: "aromatic esterase" NARROW [EC:3.1.1.2]
synonym: "aryl-ester hydrolase" NARROW [EC:3.1.1.2]
synonym: "paraoxonase activity" BROAD [EC:3.1.1.2]
xref: EC:3.1.1.2
xref: MetaCyc:ARYLESTERASE-RXN
xref: UM-BBD_enzymeID:e0535
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0004065
name: arylsulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phenol sulfate + H2O = a phenol + SO4(2-) (sulfate)." [EC:3.1.6.1]
subset: gosubset_prok
synonym: "4-methylumbelliferyl sulfatase activity" EXACT [EC:3.1.6.1]
synonym: "aryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.1]
synonym: "aryl-sulfate sulphohydrolase activity" EXACT [EC:3.1.6.1]
synonym: "aryl-sulphate sulphohydrolase activity" EXACT [EC:3.1.6.1]
synonym: "arylsulfohydrolase activity" EXACT [EC:3.1.6.1]
synonym: "arylsulphatase activity" EXACT []
synonym: "estrogen sulfatase activity" EXACT [EC:3.1.6.1]
synonym: "nitrocatechol sulfatase activity" EXACT [EC:3.1.6.1]
synonym: "p-nitrophenyl sulfatase activity" EXACT [EC:3.1.6.1]
synonym: "phenolsulfatase activity" EXACT [EC:3.1.6.1]
synonym: "phenylsulfatase activity" EXACT [EC:3.1.6.1]
synonym: "sulfatase activity" RELATED [EC:3.1.6.1]
xref: EC:3.1.6.1
xref: MetaCyc:ARYLSULFAT-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0004066
name: asparagine synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4]
subset: gosubset_prok
synonym: "AS" RELATED [EC:6.3.5.4]
synonym: "AS-B activity" EXACT [EC:6.3.5.4]
synonym: "asparagine synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4]
synonym: "asparagine synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4]
synonym: "asparagine synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.4]
synonym: "asparagine synthetase B activity" EXACT [EC:6.3.5.4]
synonym: "glutamine-dependent asparagine synthetase activity" EXACT [EC:6.3.5.4]
synonym: "L-aspartate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.4]
xref: EC:6.3.5.4
xref: MetaCyc:ASNSYNB-RXN
xref: Reactome:7213 "asparagine synthase (glutamine-hydrolyzing) activity"
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0004067
name: asparaginase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1]
subset: gosubset_prok
synonym: "alpha-asparaginase activity" EXACT [EC:3.5.1.1]
synonym: "asparaginase II" RELATED [EC:3.5.1.1]
synonym: "colaspase activity" EXACT [EC:3.5.1.1]
synonym: "crasnitin" RELATED [EC:3.5.1.1]
synonym: "elspar" RELATED [EC:3.5.1.1]
synonym: "L-asparaginase activity" EXACT [EC:3.5.1.1]
synonym: "L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.1]
synonym: "leunase activity" EXACT [EC:3.5.1.1]
xref: EC:3.5.1.1
xref: MetaCyc:ASPARAGHYD-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004068
name: aspartate 1-decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate = beta-alanine + CO2." [EC:4.1.1.11]
subset: gosubset_prok
synonym: "aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11]
synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.11]
synonym: "L-aspartate 1-carboxy-lyase (beta-alanine-forming)" EXACT [EC:4.1.1.11]
synonym: "L-aspartate 1-carboxy-lyase activity" EXACT [EC:4.1.1.11]
synonym: "L-aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11]
xref: EC:4.1.1.11
xref: MetaCyc:ASPDECARBOX-RXN
xref: MetaCyc:PWY-5155
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004069
name: L-aspartate:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1]
subset: gosubset_prok
synonym: "2-oxoglutarate-glutamate aminotransferase activity" EXACT [EC:2.6.1.1]
synonym: "AAT" RELATED [EC:2.6.1.1]
synonym: "aspartate alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1]
synonym: "aspartate aminotransferase activity" BROAD []
synonym: "aspartate transaminase activity" BROAD [EC:2.6.1.1]
synonym: "aspartate-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.1]
synonym: "aspartate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1]
synonym: "aspartic acid aminotransferase activity" BROAD [EC:2.6.1.1]
synonym: "aspartic aminotransferase activity" BROAD [EC:2.6.1.1]
synonym: "aspartyl aminotransferase activity" BROAD [EC:2.6.1.1]
synonym: "AspT" RELATED [EC:2.6.1.1]
synonym: "glutamate oxaloacetate transaminase activity" EXACT [EC:2.6.1.1]
synonym: "glutamate-oxalacetate aminotransferase activity" EXACT [EC:2.6.1.1]
synonym: "glutamate-oxalate transaminase activity" EXACT [EC:2.6.1.1]
synonym: "glutamic oxalic transaminase activity" EXACT [EC:2.6.1.1]
synonym: "glutamic--aspartic transaminase activity" EXACT [EC:2.6.1.1]
synonym: "glutamic--oxaloacetic transaminase activity" EXACT [EC:2.6.1.1]
synonym: "glutamic-aspartic aminotransferase activity" EXACT [EC:2.6.1.1]
synonym: "glutamic-oxalacetic transaminase activity" EXACT [EC:2.6.1.1]
synonym: "GOT (enzyme)" RELATED [EC:2.6.1.1]
synonym: "L-aspartate transaminase activity" BROAD [EC:2.6.1.1]
synonym: "L-aspartate-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.1]
synonym: "L-aspartate-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1]
synonym: "L-aspartate-2-oxoglutarate-transaminase activity" EXACT [EC:2.6.1.1]
synonym: "L-aspartate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1]
synonym: "L-aspartic aminotransferase activity" BROAD [EC:2.6.1.1]
synonym: "oxaloacetate transferase activity" EXACT [EC:2.6.1.1]
synonym: "oxaloacetate-aspartate aminotransferase activity" EXACT [EC:2.6.1.1]
synonym: "transaminase A activity" RELATED [EC:2.6.1.1]
xref: EC:2.6.1.1
xref: MetaCyc:ASPAMINOTRANS-RXN
xref: Reactome:7220 "L-aspartate:2-oxoglutarate aminotransferase activity"
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004070
name: aspartate carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate." [EC:2.1.3.2]
subset: gosubset_prok
synonym: "aspartate carbamyltransferase activity" EXACT [EC:2.1.3.2]
synonym: "aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2]
synonym: "aspartate transcarbamylase activity" EXACT [EC:2.1.3.2]
synonym: "aspartic acid transcarbamoylase activity" EXACT [EC:2.1.3.2]
synonym: "aspartic carbamyltransferase activity" EXACT [EC:2.1.3.2]
synonym: "aspartic transcarbamylase activity" EXACT [EC:2.1.3.2]
synonym: "ATCase activity" EXACT [EC:2.1.3.2]
synonym: "carbamoyl-phosphate:L-aspartate carbamoyltransferase activity" EXACT [EC:2.1.3.2]
synonym: "carbamoylaspartotranskinase activity" EXACT [EC:2.1.3.2]
synonym: "carbamylaspartotranskinase activity" EXACT [EC:2.1.3.2]
synonym: "L-aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2]
synonym: "L-aspartate transcarbamylase activity" EXACT [EC:2.1.3.2]
xref: EC:2.1.3.2
xref: MetaCyc:ASPCARBTRANS-RXN
xref: Reactome:7225 "aspartate carbamoyltransferase activity"
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0004071
name: aspartate-ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine." [EC:6.3.1.1]
subset: gosubset_prok
synonym: "asparagine synthetase activity" EXACT [EC:6.3.1.1]
synonym: "L-asparagine synthetase activity" EXACT [EC:6.3.1.1]
synonym: "L-aspartate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.1]
xref: EC:6.3.1.1
xref: MetaCyc:ASNSYNA-RXN
is_a: GO:0016211 ! ammonia ligase activity

[Term]
id: GO:0004072
name: aspartate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-aspartate = ADP + 4-phospho-L-aspartate." [EC:2.7.2.4]
subset: gosubset_prok
synonym: "aspartic kinase activity" EXACT [EC:2.7.2.4]
synonym: "aspartokinase activity" EXACT [EC:2.7.2.4]
synonym: "ATP:L-aspartate 4-phosphotransferase activity" EXACT [EC:2.7.2.4]
synonym: "beta-aspartokinase activity" EXACT [EC:2.7.2.4]
xref: EC:2.7.2.4
xref: MetaCyc:ASPARTATEKIN-RXN
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor
is_a: GO:0019202 ! amino acid kinase activity

[Term]
id: GO:0004073
name: aspartate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate-4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH + H+." [EC:1.2.1.11]
subset: gosubset_prok
synonym: "ASA dehydrogenase activity" EXACT [EC:1.2.1.11]
synonym: "aspartate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11]
synonym: "aspartic beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11]
synonym: "aspartic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11]
synonym: "L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.11]
synonym: "L-aspartate-beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11]
synonym: "L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)" EXACT [EC:1.2.1.11]
xref: EC:1.2.1.11
xref: MetaCyc:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004074
name: biliverdin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+." [EC:1.3.1.24]
synonym: "bilirubin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.24]
xref: EC:1.3.1.24
xref: MetaCyc:BILIVERDIN-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004075
name: biotin carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]
subset: gosubset_prok
synonym: "biotin carboxylase (component of acetyl CoA carboxylase) activity" EXACT [EC:6.3.4.14]
synonym: "biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.14]
xref: EC:6.3.4.14
xref: MetaCyc:BIOTIN-CARBOXYL-RXN
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004076
name: biotin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: dethiobiotin + sulfur = biotin." [EC:2.8.1.6, PMID:18307109]
subset: gosubset_prok
synonym: "biotin synthetase activity" EXACT [EC:2.8.1.6]
synonym: "dethiobiotin:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.6]
xref: EC:2.8.1.6
xref: MetaCyc:2.8.1.6-RXN
is_a: GO:0016783 ! sulfurtransferase activity
is_a: GO:0070283 ! radical SAM enzyme activity

[Term]
id: GO:0004077
name: biotin-[acetyl-CoA-carboxylase] ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))." [EC:6.3.4.15]
subset: gosubset_prok
synonym: "acetyl CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.15]
synonym: "acetyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.15]
synonym: "acetyl-CoA carboxylase biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15]
synonym: "biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15]
synonym: "biotin--[acetyl-CoA carboxylase] synthetase activity" EXACT [EC:6.3.4.15]
synonym: "biotin--protein ligase activity" RELATED [EC:6.3.4.15]
synonym: "biotin-acetyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.15]
synonym: "biotin-acetyl-CoA carboxylase synthetase" BROAD [EC:6.3.4.15]
synonym: "biotin-acetyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.15]
synonym: "biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.15]
synonym: "biotin:apocarboxylase ligase activity" EXACT [EC:6.3.4.15]
synonym: "HCS" RELATED [EC:6.3.4.15]
xref: EC:6.3.4.15
xref: MetaCyc:BIOTINLIG-RXN
is_a: GO:0018271 ! biotin-protein ligase activity

[Term]
id: GO:0004078
name: biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.11]
synonym: "beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.11]
synonym: "biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity" EXACT [EC:6.3.4.11]
synonym: "biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.11]
synonym: "biotin-methylcrotonoyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.11]
synonym: "biotin-methylcrotonoyl-CoA-carboxylase synthetase" BROAD [EC:6.3.4.11]
synonym: "biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.11]
synonym: "holocarboxylase-synthetase activity" EXACT [EC:6.3.4.11]
xref: EC:6.3.4.11
xref: MetaCyc:6.3.4.11-RXN
is_a: GO:0018271 ! biotin-protein ligase activity

[Term]
id: GO:0004079
name: biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase)." [EC:6.3.4.9]
synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [EC:6.3.4.9]
synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity" EXACT [EC:6.3.4.9]
synonym: "biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity" EXACT [EC:6.3.4.9]
synonym: "biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT []
synonym: "biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity" EXACT [EC:6.3.4.9]
synonym: "biotin-methylmalonyl-CoA-carboxyltransferase ligase activity" EXACT [EC:6.3.4.9]
synonym: "biotin-methylmalonyl-CoA-carboxyltransferase synthetase" BROAD [EC:6.3.4.9]
synonym: "biotin-methylmalonyl-CoA-carboxytransferase ligase activity" EXACT [EC:6.3.4.9]
synonym: "biotin-methylmalonyl-CoA-carboxytransferase synthetase activity" EXACT [EC:6.3.4.9]
synonym: "biotin-transcarboxylase synthetase activity" EXACT [EC:6.3.4.9]
synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9]
synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9]
synonym: "methylmalonyl coenzyme A holotranscarboxylase synthetase activity" EXACT [EC:6.3.4.9]
xref: EC:6.3.4.9
xref: MetaCyc:6.3.4.9-RXN
is_a: GO:0018271 ! biotin-protein ligase activity

[Term]
id: GO:0004080
name: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.10]
synonym: "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity" EXACT [EC:6.3.4.10]
synonym: "biotin-propionyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.10]
synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity" EXACT [EC:6.3.4.10]
synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity" EXACT [EC:6.3.4.10]
synonym: "biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.10]
synonym: "holocarboxylase synthetase activity" EXACT [EC:6.3.4.10]
synonym: "propionyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.10]
synonym: "propionyl-CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.10]
xref: EC:6.3.4.10
xref: MetaCyc:6.3.4.10-RXN
is_a: GO:0018271 ! biotin-protein ligase activity

[Term]
id: GO:0004081
name: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
namespace: molecular_function
def: "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate." [EC:3.6.1.17, PMID:4955726]
subset: gosubset_prok
synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17]
synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.17]
synonym: "Ap(4)Aase activity" BROAD [EC:3.6.1.17]
synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.17]
synonym: "Ap4Aase activity" BROAD [EC:3.6.1.17]
synonym: "bis(5'-adenosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17]
synonym: "bis(5'-guanosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17]
synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase" NARROW []
synonym: "diadenosine P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.17]
synonym: "diadenosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17]
synonym: "diguanosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17]
synonym: "dinucleoside tetraphosphatase activity" EXACT [EC:3.6.1.17]
synonym: "dinucleosidetetraphosphatase (asymmetrical) activity" EXACT [EC:3.6.1.17]
synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17]
xref: EC:3.6.1.17
xref: MetaCyc:3.6.1.17-RXN
is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity

[Term]
id: GO:0004082
name: bisphosphoglycerate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate." [EC:5.4.2.4]
synonym: "2,3-bisphosphoglycerate mutase activity" EXACT [EC:5.4.2.4]
synonym: "2,3-bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4]
synonym: "2,3-diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4]
synonym: "2,3-diphosphoglycerate synthase activity" EXACT [EC:5.4.2.4]
synonym: "2,3-diphosphoglyceromutase activity" EXACT [EC:5.4.2.4]
synonym: "3-phospho-D-glycerate 1,2-phosphomutase activity" EXACT [EC:5.4.2.4]
synonym: "biphosphoglycerate synthase activity" EXACT [EC:5.4.2.4]
synonym: "bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4]
synonym: "bisphosphoglyceromutase" BROAD [EC:5.4.2.4]
synonym: "BPGM activity" EXACT [EC:5.4.2.4]
synonym: "diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4]
synonym: "diphosphoglyceric mutase activity" EXACT [EC:5.4.2.4]
synonym: "diphosphoglyceromutase activity" EXACT [EC:5.4.2.4]
synonym: "DPGM" RELATED [EC:5.4.2.4]
synonym: "glycerate phosphomutase activity" EXACT [EC:5.4.2.4]
xref: EC:5.4.2.4
xref: MetaCyc:BISPHOSPHOGLYCERATE-MUTASE-RXN
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0004083
name: 2,3-bisphospho-D-glycerate 2-phosphohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 3-phosphoglycerate + phosphate." [EC:3.1.3.13]
synonym: "bisphosphoglycerate 2-phosphatase activity" BROAD [EC:3.1.3.13]
xref: EC:3.1.3.13
xref: MetaCyc:BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN
is_a: GO:0034416 ! bisphosphoglycerate phosphatase activity

[Term]
id: GO:0004084
name: branched-chain-amino-acid transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. Includes catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate and anaologous reactions involving L-isoleucine and L-valine." [EC:2.6.1.42, GOC:mah]
subset: gosubset_prok
synonym: "branched-chain amino acid aminotransferase activity" EXACT []
synonym: "branched-chain amino acid-glutamate transaminase activity" EXACT [EC:2.6.1.42]
synonym: "branched-chain aminotransferase activity" EXACT [EC:2.6.1.42]
synonym: "branched-chain-amino-acid:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.42]
synonym: "glutamate-branched-chain amino acid transaminase activity" EXACT [EC:2.6.1.42]
synonym: "L-branched chain amino acid aminotransferase activity" EXACT [EC:2.6.1.42]
synonym: "transaminase B activity" RELATED [EC:2.6.1.42]
xref: EC:2.6.1.42
xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN
xref: Reactome:70697 "branched-chain-amino-acid transaminase activity"
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004085
name: butyryl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanoyl-CoA + ETF = 2-butenoyl-CoA + reduced ETF." [EC:1.3.99.2]
subset: gosubset_prok
synonym: "3-hydroxyacyl CoA reductase activity" EXACT [EC:1.3.99.2]
synonym: "butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.2]
synonym: "butanoyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.2]
synonym: "butyryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.2]
synonym: "butyryl dehydrogenase activity" EXACT [EC:1.3.99.2]
synonym: "enoyl-coenzyme A reductase activity" EXACT [EC:1.3.99.2]
synonym: "ethylene reductase activity" EXACT [EC:1.3.99.2]
synonym: "short-chain acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.2]
synonym: "short-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.2]
synonym: "short-chain-acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.2]
synonym: "unsaturated acyl coenzyme A reductase activity" EXACT [EC:1.3.99.2]
synonym: "unsaturated acyl-CoA reductase activity" RELATED [EC:1.3.99.2]
xref: EC:1.3.99.2
xref: MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0034
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0004086
name: carbamoyl-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of a reaction that results in the formation of carbamoyl phosphate." [EC:6.3.4.16, EC:6.3.5.5, GOC:mah]
subset: gosubset_prok
synonym: "carbamoyl phosphate synthase activity" EXACT []
xref: EC:6.3.-.-
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004087
name: carbamoyl-phosphate synthase (ammonia) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ATP + NH3 + CO2 + H2O = 2 ADP + phosphate + carbamoyl phosphate." [EC:6.3.4.16]
subset: gosubset_prok
synonym: "carbamoyl phosphate synthase (ammonia) activity" EXACT []
synonym: "carbamoyl-phosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16]
synonym: "carbamoyl-phosphate synthetase I activity" EXACT [EC:6.3.4.16]
synonym: "carbamoylphosphate synthase (ammonia)" EXACT [EC:6.3.4.16]
synonym: "carbamoylphosphate synthase activity" EXACT [EC:6.3.4.16]
synonym: "carbamoylphosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16]
synonym: "carbamylphosphate synthetase activity" EXACT [EC:6.3.4.16]
synonym: "carbamylphosphate synthetase I" RELATED [EC:6.3.4.16]
synonym: "carbmoylphosphate synthetase activity" EXACT [EC:6.3.4.16]
synonym: "carbon-dioxide--ammonia ligase activity" EXACT [EC:6.3.4.16]
synonym: "carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)" EXACT [EC:6.3.4.16]
synonym: "CPS I activity" NARROW [EC:6.3.4.16]
xref: EC:6.3.4.16
xref: MetaCyc:6.3.4.16-RXN
xref: Reactome:7296 "carbamoyl-phosphate synthase (ammonia) activity"
is_a: GO:0004086 ! carbamoyl-phosphate synthase activity

[Term]
id: GO:0004088
name: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate." [EC:6.3.5.5]
subset: gosubset_prok
synonym: "carbamoyl phosphate synthase (glutamine-hydrolyzing) activity" EXACT []
synonym: "carbamoyl phosphate synthetase activity" EXACT [EC:6.3.5.5]
synonym: "carbamoyl-phosphate synthase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5]
synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5]
synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.5]
synonym: "carbamoylphosphate synthetase II activity" EXACT [EC:6.3.5.5]
synonym: "carbamyl phosphate synthetase (glutamine) activity" EXACT [EC:6.3.5.5]
synonym: "carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5]
synonym: "CPS activity" EXACT [EC:6.3.5.5]
synonym: "GD-CPSase activity" EXACT [EC:6.3.5.5]
synonym: "glutamine-dependent carbamoyl-phosphate synthase activity" EXACT [EC:6.3.5.5]
synonym: "glutamine-dependent carbamyl phosphate synthetase activity" EXACT [EC:6.3.5.5]
synonym: "hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5]
xref: EC:6.3.5.5
xref: MetaCyc:CARBPSYN-RXN
xref: Reactome:7299 "carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"
is_a: GO:0004086 ! carbamoyl-phosphate synthase activity
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0004089
name: carbonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1]
subset: gosubset_prok
synonym: "anhydrase activity" EXACT [EC:4.2.1.1]
synonym: "carbonate anhydrase activity" EXACT [EC:4.2.1.1]
synonym: "carbonate hydro-lyase (carbon-dioxide-forming)" EXACT [EC:4.2.1.1]
synonym: "carbonate hydro-lyase activity" EXACT [EC:4.2.1.1]
synonym: "carbonic acid anhydrase activity" EXACT [EC:4.2.1.1]
synonym: "carbonic anhydrase A" RELATED [EC:4.2.1.1]
synonym: "carbonic anhydrase activity" EXACT []
synonym: "carbonic dehydratase activity" EXACT [EC:4.2.1.1]
synonym: "carboxyanhydrase activity" EXACT [EC:4.2.1.1]
xref: EC:4.2.1.1
xref: MetaCyc:CARBODEHYDRAT-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004090
name: carbonyl reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184]
subset: gosubset_prok
synonym: "aldehyde reductase 1" RELATED [EC:1.1.1.184]
synonym: "aldehyde reductase I activity" RELATED [EC:1.1.1.184]
synonym: "ALR3" RELATED [EC:1.1.1.184]
synonym: "carbonyl reductase activity" EXACT [EC:1.1.1.184]
synonym: "NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184]
synonym: "NADPH2-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184]
synonym: "nonspecific NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184]
synonym: "prostaglandin 9-ketoreductase activity" NARROW [EC:1.1.1.184]
synonym: "secondary-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.184]
synonym: "xenobiotic ketone reductase activity" NARROW [EC:1.1.1.184]
xref: EC:1.1.1.184
xref: MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004091
name: carboxylesterase activity
namespace: molecular_function
alt_id: GO:0004302
alt_id: GO:0004759
alt_id: GO:0016789
def: "Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion." [EC:3.1.1.1]
subset: gosubset_prok
synonym: "Ali-esterase activity" RELATED [EC:3.1.1]
synonym: "ali-esterase activity" EXACT [EC:3.1.1]
synonym: "alpha-carboxylesterase activity" EXACT [EC:3.1.1]
synonym: "B-esterase activity" RELATED [EC:3.1.1]
synonym: "carboxyesterase activity" EXACT [EC:3.1.1]
synonym: "carboxyl ester hydrolase activity" EXACT [EC:3.1.1]
synonym: "carboxylate esterase activity" EXACT [EC:3.1.1]
synonym: "carboxylic acid esterase activity" EXACT []
synonym: "carboxylic ester hydrolase activity" EXACT []
synonym: "carboxylic esterase activity" EXACT [EC:3.1.1]
synonym: "carboxylic-ester hydrolase activity" EXACT [EC:3.1.1]
synonym: "cocaine esterase activity" NARROW [EC:3.1.1]
synonym: "esterase A" RELATED [EC:3.1.1]
synonym: "esterase B" RELATED [EC:3.1.1]
synonym: "nonspecific carboxylesterase activity" EXACT [EC:3.1.1]
synonym: "procaine esterase activity" NARROW [EC:3.1.1]
synonym: "serine esterase activity" EXACT []
synonym: "triacetin esterase" NARROW [EC:3.1.1]
synonym: "vitamin A esterase" NARROW [EC:3.1.1]
xref: EC:3.1.1
xref: EC:3.1.1.1
xref: MetaCyc:CARBOXYLESTERASE-RXN
xref: UM-BBD_enzymeID:e0631
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0004092
name: carnitine O-acetyltransferase activity
namespace: molecular_function
alt_id: GO:0004093
alt_id: GO:0004094
def: "Catalysis of the reaction: acetyl-CoA + carnitine = CoA + O-acetylcarnitine." [EC:2.3.1.7]
subset: gosubset_prok
synonym: "acetyl-CoA-carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7]
synonym: "acetyl-CoA:carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7]
synonym: "acetylcarnitine transferase activity" EXACT [EC:2.3.1.7]
synonym: "carnitine acetyl coenzyme A transferase activity" EXACT [EC:2.3.1.7]
synonym: "carnitine acetylase activity" EXACT [EC:2.3.1.7]
synonym: "carnitine acetyltransferase activity" EXACT [EC:2.3.1.7]
synonym: "carnitine O-acetyltransferase I activity" NARROW []
synonym: "carnitine O-acetyltransferase II activity" NARROW []
synonym: "carnitine-acetyl-CoA transferase activity" EXACT [EC:2.3.1.7]
synonym: "CATC" RELATED [EC:2.3.1.7]
xref: EC:2.3.1.7
xref: MetaCyc:CARNITINE-O-ACETYLTRANSFERASE-RXN
xref: Reactome:7311 "carnitine O-acetyltransferase activity"
is_a: GO:0016406 ! carnitine O-acyltransferase activity
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0004095
name: carnitine O-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." [EC:2.3.1.21]
synonym: "acylcarnitine transferase activity" EXACT [EC:2.3.1.21]
synonym: "carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21]
synonym: "carnitine palmitoyltransferase I" RELATED [EC:2.3.1.21]
synonym: "carnitine palmitoyltransferase II" RELATED [EC:2.3.1.21]
synonym: "carnitine palmitoyltransferase-A" RELATED [EC:2.3.1.21]
synonym: "CPT" RELATED [EC:2.3.1.21]
synonym: "CPT I (outer membrane carnitine palmitoyl transferase)" RELATED [EC:2.3.1.21]
synonym: "CPT-A" RELATED [EC:2.3.1.21]
synonym: "CPT-B" RELATED [EC:2.3.1.21]
synonym: "CPTi" RELATED [EC:2.3.1.21]
synonym: "CPTo" RELATED [EC:2.3.1.21]
synonym: "L-carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21]
synonym: "outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21]
synonym: "palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity" EXACT [EC:2.3.1.21]
synonym: "palmitoylcarnitine transferase activity" EXACT [EC:2.3.1.21]
xref: EC:2.3.1.21
xref: MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN
xref: Reactome:7324 "carnitine O-palmitoyltransferase activity"
is_a: GO:0016406 ! carnitine O-acyltransferase activity
is_a: GO:0016416 ! O-palmitoyltransferase activity

[Term]
id: GO:0004096
name: catalase activity
namespace: molecular_function
alt_id: GO:0016952
alt_id: GO:0016953
def: "Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O." [EC:1.11.1.6]
subset: gosubset_prok
synonym: "bacterial catalase-peroxidase activity" NARROW []
synonym: "caperase activity" EXACT [EC:1.11.1.6]
synonym: "CAT" RELATED [EC:1.11.1.6]
synonym: "catalase reaction" EXACT []
synonym: "catalase-peroxidase activity" EXACT [EC:1.11.1.6]
synonym: "equilase activity" EXACT [EC:1.11.1.6]
synonym: "haem catalase activity" NARROW []
synonym: "heme catalase activity" NARROW []
synonym: "hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.6]
synonym: "manganese catalase activity" NARROW []
synonym: "optidase activity" EXACT [EC:1.11.1.6]
xref: EC:1.11.1.6
xref: MetaCyc:CATAL-RXN
xref: Reactome:76029 "catalase activity"
xref: UM-BBD_enzymeID:e0834
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0004097
name: catechol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O." [EC:1.10.3.1]
subset: gosubset_prok
synonym: "1,2-benzenediol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.1]
synonym: "catecholase" BROAD [EC:1.10.3.1]
synonym: "diphenol oxidase activity" EXACT [EC:1.10.3.1]
synonym: "dopa oxidase" BROAD [EC:1.10.3.1]
synonym: "o-diphenol oxidoreductase" BROAD [EC:1.10.3.1]
synonym: "o-diphenol:oxygen oxidoreductase" BROAD [EC:1.10.3.1]
synonym: "o-diphenolase activity" EXACT [EC:1.10.3.1]
synonym: "phenolase activity" BROAD [EC:1.10.3.1]
synonym: "polyphenol oxidase activity" EXACT [EC:1.10.3.1]
synonym: "pyrocatechol oxidase" BROAD [EC:1.10.3.1]
synonym: "tyrosinase activity" BROAD [EC:1.10.3.1]
xref: EC:1.10.3.1
xref: MetaCyc:CATECHOL-OXIDASE-RXN
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0004098
name: cerebroside-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + SO4(2-) (sulfate)." [EC:3.1.6.8]
subset: gosubset_prok
synonym: "arylsulfatase A activity" EXACT [EC:3.1.6.8]
synonym: "cerebroside sulfate sulfatase activity" EXACT [EC:3.1.6.8]
synonym: "cerebroside-3-sulfate 3-sulfohydrolase activity" EXACT [EC:3.1.6.8]
synonym: "cerebroside-sulphatase activity" EXACT []
xref: EC:3.1.6.8
xref: MetaCyc:CEREBROSIDE-SULFATASE-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0004099
name: chitin deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: chitin + H2O = chitosan + acetate." [EC:3.5.1.41]
subset: gosubset_prok
synonym: "chitin amidohydrolase activity" EXACT [EC:3.5.1.41]
xref: EC:3.5.1.41
xref: MetaCyc:CHITIN-DEACETYLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0004100
name: chitin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + ((1,4)-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + ((1,4)-(N-acetyl-beta-D-glucosaminyl))(n+1)." [EC:2.4.1.16]
subset: gosubset_prok
synonym: "chitin synthetase activity" EXACT [EC:2.4.1.16]
synonym: "chitin-UDP acetyl-glucosaminyl transferase activity" EXACT [EC:2.4.1.16]
synonym: "chitin-UDP N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16]
synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16]
synonym: "trans-N-acetylglucosaminosylase activity" EXACT [EC:2.4.1.16]
synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.16]
xref: EC:2.4.1.16
xref: MetaCyc:CHITIN-SYNTHASE-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0004102
name: choline O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + choline = CoA + O-acetylcholine." [EC:2.3.1.6]
subset: gosubset_prok
synonym: "acetyl-CoA:choline O-acetyltransferase activity" EXACT [EC:2.3.1.6]
synonym: "CHOACTase activity" EXACT [EC:2.3.1.6]
synonym: "choline acetylase activity" EXACT [EC:2.3.1.6]
synonym: "choline acetyltransferase activity" EXACT [EC:2.3.1.6]
xref: EC:2.3.1.6
xref: MetaCyc:CHOLINE-O-ACETYLTRANSFERASE-RXN
xref: Reactome:264627 "choline O-acetyltransferase activity"
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0004103
name: choline kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + choline = ADP + O-phosphocholine." [EC:2.7.1.32]
subset: gosubset_prok
synonym: "ATP:choline phosphotransferase activity" EXACT [EC:2.7.1.32]
synonym: "choline kinase (phosphorylating)" EXACT [EC:2.7.1.32]
synonym: "choline phosphokinase activity" EXACT [EC:2.7.1.32]
synonym: "choline-ethanolamine kinase activity" EXACT [EC:2.7.1.32]
xref: EC:2.7.1.32
xref: MetaCyc:CHOLINE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004104
name: cholinesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8]
subset: gosubset_prok
synonym: "acylcholine acylhydrolase activity" EXACT [EC:3.1.1.8]
synonym: "anticholineesterase activity" EXACT [EC:3.1.1.8]
synonym: "benzoylcholinesterase activity" EXACT [EC:3.1.1.8]
synonym: "BtChoEase activity" EXACT [EC:3.1.1.8]
synonym: "butyrylcholine esterase activity" EXACT [EC:3.1.1.8]
synonym: "butyrylcholinesterase activity" EXACT [EC:3.1.1.8]
synonym: "choline esterase activity" EXACT [EC:3.1.1.8]
synonym: "choline esterase II (unspecific) activity" EXACT [EC:3.1.1.8]
synonym: "non-specific cholinesterase activity" EXACT [EC:3.1.1.8]
synonym: "propionylcholinesterase activity" EXACT [EC:3.1.1.8]
synonym: "pseudocholinesterase activity" EXACT [EC:3.1.1.8]
xref: EC:3.1.1.8
xref: MetaCyc:CHOLINESTERASE-RXN
xref: Reactome:8144 "cholinesterase activity"
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0004105
name: choline-phosphate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline." [EC:2.7.7.15]
subset: gosubset_prok
synonym: "CDP-choline pyrophosphorylase activity" EXACT [EC:2.7.7.15]
synonym: "CDP-choline synthetase activity" EXACT [EC:2.7.7.15]
synonym: "choline phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.15]
synonym: "CTP-phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15]
synonym: "CTP:choline-phosphate cytidylyltransferase activity" EXACT []
synonym: "CTP:phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15]
synonym: "CTP:phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15]
synonym: "cytidine diphosphocholine pyrophosphorylase activity" EXACT [EC:2.7.7.15]
synonym: "phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15]
synonym: "phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15]
synonym: "phosphorylcholine transferase activity" EXACT [EC:2.7.7.15]
synonym: "phosphorylcholine:CTP cytidylyltransferase activity" EXACT [EC:2.7.7.15]
xref: EC:2.7.7.15
xref: MetaCyc:2.7.7.15-RXN
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0004106
name: chorismate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: chorismate = prephenate." [EC:5.4.99.5]
subset: gosubset_prok
synonym: "chorismate pyruvatemutase activity" EXACT [EC:5.4.99.5]
synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:5.4.99.5]
xref: EC:5.4.99.5
xref: MetaCyc:CHORISMATEMUT-RXN
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0004107
name: chorismate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate." [EC:4.2.3.5]
subset: gosubset_prok
synonym: "5-enolpyruvylshikimate-3-phosphate phospholyase activity" EXACT [EC:4.2.3.5]
synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)" EXACT [EC:4.2.3.5]
synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity" EXACT [EC:4.2.3.5]
xref: EC:4.2.3.5
xref: MetaCyc:CHORISMATE-SYNTHASE-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0004108
name: citrate (Si)-synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group." [EC:2.3.3.1, ISBN:0121227073]
comment: Note that this function was formerly EC:4.1.3.7.
subset: gosubset_prok
synonym: "(R)-citric synthase activity" EXACT [EC:2.3.3.1]
synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]" RELATED [EC:2.3.3.1]
synonym: "citrate condensing enzyme activity" EXACT [EC:2.3.3.1]
synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity" EXACT [EC:2.3.3.1]
synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)" EXACT [EC:2.3.3.1]
synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]" RELATED [EC:2.3.3.1]
synonym: "citrate oxaloacetate-lyase, CoA-acetylating activity" EXACT [EC:2.3.3.1]
synonym: "citrate synthase activity" BROAD [EC:2.3.3.1]
synonym: "citrate synthetase activity" EXACT [EC:2.3.3.1]
synonym: "citric synthase activity" EXACT [EC:2.3.3.1]
synonym: "citric-condensing enzyme activity" EXACT [EC:2.3.3.1]
synonym: "citrogenase activity" EXACT [EC:2.3.3.1]
synonym: "condensing enzyme activity" BROAD [EC:2.3.3.1]
synonym: "oxalacetic transacetase activity" EXACT [EC:2.3.3.1]
synonym: "oxaloacetate transacetase activity" EXACT [EC:2.3.3.1]
xref: EC:2.3.3.1
xref: MetaCyc:CITSYN-RXN
xref: Reactome:8157 "citrate (Si)-synthase activity"
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0004109
name: coproporphyrinogen oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O." [EC:1.3.3.3]
subset: gosubset_prok
synonym: "coprogen oxidase activity" EXACT []
synonym: "coproporphyrinogen-III oxidase activity" EXACT []
synonym: "coproporphyrinogen:oxygen oxidoreductase (decarboxylating)" EXACT [EC:1.3.3.3]
synonym: "coproporphyrinogenase activity" EXACT []
xref: EC:1.3.3.3
xref: MetaCyc:RXN0-1461
xref: Reactome:8160 "coproporphyrinogen oxidase activity"
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0004110
name: corticosteroid side-chain-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al." [EC:5.3.1.21]
synonym: "11-deoxycorticosterone aldose-ketose-isomerase activity" EXACT [EC:5.3.1.21]
synonym: "11-deoxycorticosterone ketol-isomerase activity" EXACT [EC:5.3.1.21]
xref: EC:5.3.1.21
xref: MetaCyc:CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004111
name: creatine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + creatine = ADP + phosphocreatine." [EC:2.7.3.2]
synonym: "adenosine triphosphate-creatine transphosphorylase activity" EXACT [EC:2.7.3.2]
synonym: "ATP:creatine N-phosphotransferase activity" EXACT [EC:2.7.3.2]
synonym: "ATP:creatine phosphotransferase activity" EXACT [EC:2.7.3.2]
synonym: "BB-CK" RELATED [EC:2.7.3.2]
synonym: "CK" RELATED [EC:2.7.3.2]
synonym: "CK-BB" RELATED [EC:2.7.3.2]
synonym: "CK-MB" RELATED [EC:2.7.3.2]
synonym: "CK-MM" RELATED [EC:2.7.3.2]
synonym: "CKMiMi" RELATED [EC:2.7.3.2]
synonym: "creatine phosphokinase activity" EXACT [EC:2.7.3.2]
synonym: "creatine phosphotransferase activity" EXACT [EC:2.7.3.2]
synonym: "MB-CK" RELATED [EC:2.7.3.2]
synonym: "Mi-CK" RELATED [EC:2.7.3.2]
synonym: "MiMi-CK" RELATED [EC:2.7.3.2]
synonym: "MM-CK" RELATED [EC:2.7.3.2]
synonym: "phosphocreatine kinase activity" EXACT [EC:2.7.3.2]
xref: EC:2.7.3.2
xref: MetaCyc:CREATINE-KINASE-RXN
xref: Reactome:8202 "creatine kinase activity"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0004112
name: cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate." [GOC:mah]
subset: gosubset_prok
xref: EC:3.1.4.-
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0004113
name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate." [EC:3.1.4.37]
subset: gosubset_prok
synonym: "2',3'-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.37]
synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.37]
synonym: "2',3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT []
synonym: "2',3'-cyclic nucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.4.37]
synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.37]
synonym: "2':3'-CNMP-3'-ase activity" EXACT [EC:3.1.4.37]
synonym: "2':3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37]
synonym: "CNPase activity" EXACT [EC:3.1.4.37]
synonym: "cyclic 2',3'-nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37]
synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.37]
synonym: "cyclic-CMP phosphodiesterase activity" NARROW [EC:3.1.4.37]
synonym: "nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity" EXACT [EC:3.1.4.37]
xref: EC:3.1.4.37
xref: MetaCyc:3.1.4.37-RXN
is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004114
name: 3',5'-cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]
subset: gosubset_prok
synonym: "3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "3',5' cyclic-nucleotide phosphodiesterase activity" EXACT []
synonym: "3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17]
synonym: "3',5'-cyclonucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17]
synonym: "3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17]
synonym: "cyclic 3',5'-mononucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "cyclic 3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "cyclic 3',5'-phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "cyclic 3',5-nucleotide monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "cyclic AMP phosphodiesterase activity" NARROW [EC:3.1.4.17]
synonym: "cyclic nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17]
synonym: "nucleoside 3',5'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.17]
synonym: "nucleoside-3',5-monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17]
synonym: "PDE" RELATED [EC:3.1.4.17]
xref: EC:3.1.4.17
xref: MetaCyc:3.1.4.17-RXN
is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004115
name: 3',5'-cyclic-AMP phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate." [GOC:ai]
subset: gosubset_prok
synonym: "3',5' cAMP-specific phosphodiesterase activity" EXACT []
synonym: "3',5'-cAMP-specific phosphodiesterase activity" EXACT []
synonym: "3',5'-cyclic-AMP-specific phosphodiesterase activity" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity" EXACT []
synonym: "cAMP-specific phosphodiesterase activity" EXACT []
synonym: "cyclic AMP-specific phosphodiesterase activity" EXACT []
xref: EC:3.1.4.-
xref: MetaCyc:RXN0-5038
xref: Reactome:8212 "3',5'-cyclic-AMP phosphodiesterase activity"
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004117
name: calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin." [GOC:mah]
xref: EC:3.1.4.-
xref: Reactome:8219 "calmodulin-dependent cyclic-nucleotide phosphodiesterase activity"
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004118
name: cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP." [GOC:mah]
xref: EC:3.1.4.-
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004119
name: cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP." [GOC:mah]
xref: EC:3.1.4.-
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004120
name: photoreceptor cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of bonds in a cyclic nucleotide (nucleoside cyclic phosphate + H2O = nucleoside phosphate)." [EC:3.1.4.-]
xref: EC:3.1.4.-
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0004121
name: cystathionine beta-lyase activity
namespace: molecular_function
alt_id: GO:0008799
def: "Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate." [EC:4.4.1.8]
subset: gosubset_prok
synonym: "beta C-S lyase activity" EXACT [EC:4.4.1.8]
synonym: "beta-cystathionase activity" EXACT [EC:4.4.1.8]
synonym: "cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8]
synonym: "cystine lyase activity" EXACT [EC:4.4.1.8]
synonym: "L-cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8]
synonym: "L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.8]
xref: EC:4.4.1.8
xref: MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0004122
name: cystathionine beta-synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O." [EC:4.2.1.22]
subset: gosubset_prok
synonym: "beta-thionase activity" EXACT [EC:4.2.1.22]
synonym: "L-serine hydro-lyase (adding homocysteine)" EXACT [EC:4.2.1.22]
synonym: "L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [EC:4.2.1.22]
synonym: "methylcysteine synthase activity" EXACT [EC:4.2.1.22]
synonym: "serine sulfhydrase activity" EXACT [EC:4.2.1.22]
synonym: "serine sulfhydrylase activity" EXACT [EC:4.2.1.22]
xref: EC:4.2.1.22
xref: MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004123
name: cystathionine gamma-lyase activity
namespace: molecular_function
alt_id: GO:0016225
def: "Catalysis of the reaction: L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate." [EC:4.4.1.1]
subset: gosubset_prok
synonym: "cystalysin" RELATED [EC:4.4.1.1]
synonym: "cystathionase activity" EXACT [EC:4.4.1.1]
synonym: "cystathioninase activity" EXACT [EC:4.4.1.1]
synonym: "cysteine desulfhydrase activity" EXACT []
synonym: "cystine desulfhydrase activity" EXACT [EC:4.4.1.1]
synonym: "gamma-CTL" RELATED [EC:4.4.1.1]
synonym: "gamma-cystathionase activity" EXACT [EC:4.4.1.1]
synonym: "homoserine deaminase activity" EXACT [EC:4.4.1.1]
synonym: "homoserine deaminase-cystathionase activity" EXACT [EC:4.4.1.1]
synonym: "homoserine dehydratase activity" EXACT [EC:4.4.1.1]
synonym: "L-cystathionine cysteine-lyase (deaminating)" EXACT [EC:4.4.1.1]
synonym: "L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.1]
xref: EC:4.4.1.1
xref: MetaCyc:CYSTAGLY-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0004124
name: cysteine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate." [EC:4.2.99.8]
comment: Note that this function was formerly 4.2.99.8.
subset: gosubset_prok
synonym: "3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47]
synonym: "acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47]
synonym: "cysteine synthetase activity" EXACT [EC:2.5.1.47]
synonym: "O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity" EXACT [EC:2.5.1.47]
synonym: "O-acetyl-L-serine sulfhydrylase activity" EXACT [EC:2.5.1.47]
synonym: "O-acetyl-L-serine sulfohydrolase activity" EXACT [EC:2.5.1.47]
synonym: "O-acetylserine (thiol)-lyase A activity" NARROW [EC:2.5.1.47]
synonym: "O-acetylserine (thiol)-lyase activity" EXACT [EC:2.5.1.47]
synonym: "O-acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47]
synonym: "O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)" EXACT [EC:2.5.1.47]
synonym: "O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47]
synonym: "OAS sulfhydrylase activity" EXACT [EC:2.5.1.47]
xref: EC:2.5.1.47
xref: MetaCyc:ACSERLY-RXN
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0004125
name: L-seryl-tRNASec selenium transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate." [EC:2.9.1.1]
subset: gosubset_prok
synonym: "cysteinyl-tRNA(Sec)-selenium transferase activity" EXACT [EC:2.9.1.1]
synonym: "cysteinyl-tRNA(Sel)-selenium transferase activity" EXACT [EC:2.9.1.1]
synonym: "cysteinyl-tRNA(Ser) selenium transferase activity" EXACT []
synonym: "cysteinyl-tRNASec-selenium transferase activity" EXACT [EC:2.9.1.1]
synonym: "cysteinyl-tRNASel-selenium transferase activity" EXACT [EC:2.9.1.1]
synonym: "L-selenocysteinyl-tRNA(Sec) synthase activity" EXACT [EC:2.9.1.1]
synonym: "L-selenocysteinyl-tRNA(Sel) synthase activity" EXACT [EC:2.9.1.1]
synonym: "L-selenocysteinyl-tRNASec synthase activity" EXACT [EC:2.9.1.1]
synonym: "L-selenocysteinyl-tRNASel synthase activity" EXACT [EC:2.9.1.1]
synonym: "L-seryl-tRNA(Ser) selenium transferase activity" EXACT []
synonym: "selenocysteine synthase activity" EXACT []
synonym: "selenocysteinyl-tRNA(Ser) synthase activity" EXACT []
synonym: "selenophosphate:L-seryl-tRNASec selenium transferase activity" EXACT [EC:2.9.1.1]
xref: EC:2.9.1.1
xref: MetaCyc:2.9.1.1-RXN
is_a: GO:0016786 ! selenotransferase activity

[Term]
id: GO:0004126
name: cytidine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytidine + H2O = uridine + NH3." [EC:3.5.4.5]
subset: gosubset_prok
synonym: "cytidine aminohydrolase activity" EXACT [EC:3.5.4.5]
synonym: "cytosine nucleoside deaminase activity" EXACT [EC:3.5.4.5]
xref: EC:3.5.4.5
xref: MetaCyc:CYTIDEAM2-RXN
xref: Reactome:8270 "cytidine deaminase activity"
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004127
name: cytidylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP." [EC:2.7.4.14]
subset: gosubset_prok
synonym: "ATP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14]
synonym: "ATP:UMP-CMP phosphotransferase activity" EXACT [EC:2.7.4.14]
synonym: "CMP kinase activity" NARROW [EC:2.7.4.14]
synonym: "CTP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14]
synonym: "cytidine monophosphate kinase activity" EXACT [EC:2.7.4.14]
synonym: "dCMP kinase activity" NARROW [EC:2.7.4.14]
synonym: "deoxycytidine monophosphokinase activity" EXACT [EC:2.7.4.14]
synonym: "deoxycytidylate kinase activity" BROAD [EC:2.7.4.14]
synonym: "pyrimidine nucleoside monophosphate kinase activity" EXACT [EC:2.7.4.14]
synonym: "UMP-CMP kinase activity" EXACT [EC:2.7.4.14]
xref: EC:2.7.4.14
xref: MetaCyc:CMPKI-RXN
is_a: GO:0019201 ! nucleotide kinase activity

[Term]
id: GO:0004128
name: cytochrome-b5 reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5)." [EC:1.6.2.2, ISBN:0198547684]
synonym: "cytochrome b5 reductase activity" EXACT [EC:1.6.2.2]
synonym: "dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2]
synonym: "NADH 5alpha-reductase activity" EXACT [EC:1.6.2.2]
synonym: "NADH-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2]
synonym: "NADH-cytochrome-b5 reductase activity" EXACT [EC:1.6.2.2]
synonym: "NADH-ferricytochrome b5 oxidoreductase activity" EXACT [EC:1.6.2.2]
synonym: "NADH:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.6.2.2]
synonym: "reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2]
xref: EC:1.6.2.2
xref: MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN
xref: Reactome:8276 "cytochrome-b5 reductase activity"
is_a: GO:0016653 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor

[Term]
id: GO:0004129
name: cytochrome-c oxidase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
subset: gosubset_prok
synonym: "aa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1]
synonym: "ba3-type cytochrome c oxidase" NARROW [EC:1.9.3.1]
synonym: "caa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1]
synonym: "cbb3-type cytochrome c oxidase" NARROW [EC:1.9.3.1]
synonym: "complex IV (mitochondrial electron transport) activity" RELATED [EC:1.9.3.1]
synonym: "cytochrome a3 activity" NARROW [EC:1.9.3.1]
synonym: "cytochrome aa3 activity" NARROW [EC:1.9.3.1]
synonym: "cytochrome oxidase activity" RELATED [EC:1.9.3.1]
synonym: "ferrocytochrome c oxidase" NARROW [EC:1.9.3.1]
synonym: "ferrocytochrome-c:oxygen oxidoreductase" NARROW [EC:1.9.3.1]
synonym: "indophenol oxidase" NARROW [EC:1.9.3.1]
synonym: "indophenolase" NARROW [EC:1.9.3.1]
synonym: "NADH cytochrome c oxidase" EXACT [EC:1.9.3.1]
synonym: "warburg's respiratory enzyme activity" RELATED [EC:1.9.3.1]
xref: EC:1.9.3.1
xref: MetaCyc:CYTOCHROME-C-OXIDASE-RXN
xref: Reactome:8283 "cytochrome-c oxidase activity"
is_a: GO:0015002 ! heme-copper terminal oxidase activity
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0016676 ! oxidoreductase activity, acting on heme group of donors, oxygen as acceptor

[Term]
id: GO:0004130
name: cytochrome-c peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O." [EC:1.11.1.5]
subset: gosubset_prok
synonym: "apocytochrome c peroxidase activity" EXACT [EC:1.11.1.5]
synonym: "cytochrome c peroxidase activity" EXACT [EC:1.11.1.5]
synonym: "cytochrome c-551 peroxidase activity" EXACT [EC:1.11.1.5]
synonym: "cytochrome c-H2O oxidoreductase activity" EXACT [EC:1.11.1.5]
synonym: "cytochrome peroxidase activity" EXACT [EC:1.11.1.5]
synonym: "ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.5]
synonym: "mesocytochrome c peroxidase azide" RELATED [EC:1.11.1.5]
synonym: "mesocytochrome c peroxidase cyanate" RELATED [EC:1.11.1.5]
synonym: "mesocytochrome c peroxidase cyanide" RELATED [EC:1.11.1.5]
xref: EC:1.11.1.5
xref: MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0004131
name: cytosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytosine + H2O = uracil + NH3." [EC:3.5.4.1]
subset: gosubset_prok
synonym: "cytosine aminohydrolase activity" EXACT [EC:3.5.4.1]
synonym: "isocytosine deaminase activity" EXACT [EC:3.5.4.1]
xref: EC:3.5.4.1
xref: MetaCyc:CYTDEAM-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004132
name: dCMP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: dCMP + H2O = dUMP + NH3." [EC:3.5.4.12]
subset: gosubset_prok
synonym: "dCMP aminohydrolase activity" EXACT [EC:3.5.4.12]
synonym: "deoxy-CMP-deaminase activity" EXACT [EC:3.5.4.12]
synonym: "deoxycytidine monophosphate deaminase activity" EXACT [EC:3.5.4.12]
synonym: "deoxycytidine-5'-monophosphate aminohydrolase activity" EXACT [EC:3.5.4.12]
synonym: "deoxycytidine-5'-phosphate deaminase activity" EXACT [EC:3.5.4.12]
synonym: "deoxycytidylate aminohydrolase activity" EXACT [EC:3.5.4.12]
synonym: "deoxycytidylate deaminase activity" EXACT [EC:3.5.4.12]
xref: EC:3.5.4.12
xref: MetaCyc:DCMP-DEAMINASE-RXN
xref: Reactome:8340 "dCMP deaminase activity"
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004133
name: glycogen debranching enzyme activity
namespace: molecular_function
def: "Catalysis of the cleavage of branch points in branched glycogen polymers." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0004134
name: 4-alpha-glucanotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan." [EC:2.4.1.25]
subset: gosubset_prok
synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity" EXACT [EC:2.4.1.25]
synonym: "amylomaltase activity" EXACT [EC:2.4.1.25]
synonym: "D-enzyme activity" RELATED [EC:2.4.1.25]
synonym: "debranching enzyme maltodextrin glycosyltransferase activity" EXACT [EC:2.4.1.25]
synonym: "dextrin glycosyltransferase activity" RELATED [EC:2.4.1.25]
synonym: "dextrin transglycosylase activity" EXACT [EC:2.4.1.25]
synonym: "disproportionating enzyme activity" RELATED [EC:2.4.1.25]
synonym: "oligo-1,4-1,4-glucantransferase activity" EXACT [EC:2.4.1.25]
xref: EC:2.4.1.25
xref: MetaCyc:AMYLOMALT-RXN
xref: MetaCyc:RXN-1828
xref: MetaCyc:RXN-9023
xref: Reactome:8344 "4-alpha-glucanotransferase activity"
is_a: GO:0004133 ! glycogen debranching enzyme activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0004135
name: amylo-alpha-1,6-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the 1,6 glycosidic linkages present." [EC:3.2.1.33, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "amylo-1,6-glucosidase activity" EXACT []
synonym: "amylopectin 1,6-glucosidase activity" EXACT [EC:3.2.1.33]
synonym: "dextrin 6-alpha-D-glucosidase activity" RELATED [EC:3.2.1.33]
synonym: "dextrin-1,6-glucosidase activity" EXACT [EC:3.2.1.33]
synonym: "glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.33]
xref: EC:3.2.1.33
xref: MetaCyc:3.2.1.33-RXN
xref: Reactome:8347 "amylo-alpha-1,6-glucosidase activity"
is_a: GO:0004133 ! glycogen debranching enzyme activity
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0004136
name: deoxyadenosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + deoxyadenosine = ADP + dAMP." [EC:2.7.1.76]
subset: gosubset_prok
synonym: "ATP:deoxyadenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.76]
synonym: "deoxyadenosine kinase (phosphorylating)" EXACT [EC:2.7.1.76]
synonym: "purine-deoxyribonucleoside kinase activity" EXACT [EC:2.7.1.76]
xref: EC:2.7.1.76
xref: MetaCyc:DEOXYADENOSINE-KINASE-RXN
is_a: GO:0019136 ! deoxynucleoside kinase activity

[Term]
id: GO:0004137
name: deoxycytidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP." [EC:2.7.1.74]
subset: gosubset_prok
synonym: "2'-deoxycytidine kinase activity" EXACT [EC:2.7.1.74]
synonym: "Ara-C kinase activity" EXACT [EC:2.7.1.74]
synonym: "arabinofuranosylcytosine kinase activity" EXACT [EC:2.7.1.74]
synonym: "deoxycytidine kinase (phosphorylating)" EXACT [EC:2.7.1.74]
synonym: "deoxycytidine-cytidine kinase activity" EXACT [EC:2.7.1.74]
synonym: "NTP:deoxycytidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.74]
xref: EC:2.7.1.74
xref: MetaCyc:DEOXYCYTIDINE-KINASE-RXN
is_a: GO:0019136 ! deoxynucleoside kinase activity

[Term]
id: GO:0004138
name: deoxyguanosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + deoxyguanosine = ADP + dGMP." [EC:2.7.1.113]
subset: gosubset_prok
synonym: "(dihydroxypropoxymethyl)guanine kinase activity" EXACT [EC:2.7.1.113]
synonym: "2'-deoxyguanosine kinase activity" EXACT [EC:2.7.1.113]
synonym: "ATP:deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113]
synonym: "deoxyguanosine kinase (phosphorylating)" EXACT [EC:2.7.1.113]
synonym: "NTP-deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113]
xref: EC:2.7.1.113
xref: MetaCyc:DEOXYGUANOSINE-KINASE-RXN
is_a: GO:0019136 ! deoxynucleoside kinase activity

[Term]
id: GO:0004139
name: deoxyribose-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde." [EC:4.1.2.4]
subset: gosubset_prok
synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)" EXACT [EC:4.1.2.4]
synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity" EXACT [EC:4.1.2.4]
synonym: "2-deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4]
synonym: "deoxyriboaldolase activity" RELATED [EC:4.1.2.4]
synonym: "deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4]
synonym: "phosphodeoxyriboaldolase activity" EXACT [EC:4.1.2.4]
xref: EC:4.1.2.4
xref: MetaCyc:DEOXYRIBOSE-P-ALD-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0004140
name: dephospho-CoA kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + dephospho-CoA = ADP + CoA." [EC:2.7.1.24]
subset: gosubset_prok
synonym: "3'-dephospho-CoA kinase activity" EXACT [EC:2.7.1.24]
synonym: "ATP:dephospho-CoA 3'-phosphotransferase activity" EXACT [EC:2.7.1.24]
synonym: "dephosphocoenzyme A kinase (phosphorylating)" EXACT [EC:2.7.1.24]
synonym: "dephosphocoenzyme A kinase activity" RELATED [EC:2.7.1.24]
xref: EC:2.7.1.24
xref: MetaCyc:DEPHOSPHOCOAKIN-RXN
xref: Reactome:8372 "dephospho-CoA kinase activity"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004141
name: dethiobiotin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin." [EC:6.3.3.3]
subset: gosubset_prok
synonym: "7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.3]
synonym: "desthiobiotin synthase activity" EXACT [EC:6.3.3.3]
synonym: "DTB synthetase activity" EXACT [EC:6.3.3.3]
xref: EC:6.3.3.3
xref: MetaCyc:DETHIOBIOTIN-SYN-RXN
is_a: GO:0016882 ! cyclo-ligase activity

[Term]
id: GO:0004142
name: diacylglycerol cholinephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine." [EC:2.7.8.2]
synonym: "1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity" EXACT [EC:2.7.8.2]
synonym: "1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2]
synonym: "1-alkyl-2-acetylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2]
synonym: "alkylacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2]
synonym: "alkylacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2]
synonym: "CDP-choline diglyceride phosphotransferase activity" EXACT [EC:2.7.8.2]
synonym: "CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2]
synonym: "cholinephosphotransferase activity" RELATED [EC:2.7.8.2]
synonym: "CPT" RELATED [EC:2.7.8.2]
synonym: "cytidine diphosphocholine glyceride transferase activity" EXACT [EC:2.7.8.2]
synonym: "cytidine diphosphorylcholine diglyceride transferase activity" EXACT [EC:2.7.8.2]
synonym: "diacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2]
synonym: "phosphocholine diacylglyceroltransferase activity" EXACT [EC:2.7.8.2]
synonym: "phosphorylcholine--glyceride transferase activity" EXACT [EC:2.7.8.2]
synonym: "sn-1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2]
xref: EC:2.7.8.2
xref: MetaCyc:RXN-5781
is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity

[Term]
id: GO:0004143
name: diacylglycerol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate." [EC:2.7.1.107, GOC:elh]
subset: gosubset_prok
synonym: "1,2-diacylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.107]
synonym: "1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107]
synonym: "arachidonoyl-specific diacylglycerol kinase activity" EXACT [EC:2.7.1.107]
synonym: "ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [EC:2.7.1.107]
synonym: "ATP:diacylglycerol phosphotransferase activity" NARROW [EC:2.7.1.107]
synonym: "CTP:diacylglycerol kinase activity" NARROW []
synonym: "DG kinase activity" EXACT [EC:2.7.1.107]
synonym: "DGK activity" EXACT [EC:2.7.1.107]
synonym: "diacylglycerol:ATP kinase activity" NARROW [EC:2.7.1.107]
synonym: "diglyceride kinase activity" EXACT [EC:2.7.1.107]
synonym: "sn-1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107]
xref: EC:2.7.1.107
xref: MetaCyc:DIACYLGLYKIN-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004144
name: diacylglycerol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20]
subset: gosubset_prok
synonym: "1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20]
synonym: "acyl-CoA:1,2-diacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.20]
synonym: "diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20]
synonym: "diglyceride acyltransferase activity" EXACT [EC:2.3.1.20]
synonym: "diglyceride O-acyltransferase activity" EXACT [EC:2.3.1.20]
synonym: "palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20]
xref: EC:2.3.1.20
xref: MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN
xref: Reactome:8383 "diacylglycerol O-acyltransferase activity"
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity

[Term]
id: GO:0004145
name: diamine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine." [EC:2.3.1.57]
subset: gosubset_prok
synonym: "acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity" EXACT [EC:2.3.1.57]
synonym: "acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity" NARROW []
synonym: "diamine acetyltransferase activity" EXACT []
synonym: "putrescine (diamine)-acetylating enzyme activity" NARROW []
synonym: "putrescine acetylase activity" NARROW [EC:2.3.1.57]
synonym: "putrescine acetyltransferase activity" NARROW [EC:2.3.1.57]
synonym: "putrescine N-acetyltransferase activity" NARROW [EC:2.3.1.57]
synonym: "spermidine acetyltransferase activity" NARROW [EC:2.3.1.57]
synonym: "spermidine N(1)-acetyltransferase activity" NARROW [EC:2.3.1.57]
synonym: "spermidine N1-acetyltransferase activity" EXACT [EC:2.3.1.57]
synonym: "spermidine/spermine N1-acetyltransferase activity" EXACT [EC:2.3.1.57]
synonym: "spermine acetyltransferase" NARROW []
synonym: "spermine N(1)-acetyltransferase" NARROW []
synonym: "spermine N-acetyltransferase" RELATED []
xref: EC:2.3.1.57
xref: MetaCyc:DIAMACTRANS-RXN
xref: Reactome:8388 "diamine N-acetyltransferase activity"
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004146
name: dihydrofolate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3]
subset: gosubset_prok
synonym: "5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.3]
synonym: "7,8-dihydrofolate reductase activity" EXACT [EC:1.5.1.3]
synonym: "DHFR" RELATED [EC:1.5.1.3]
synonym: "dihydrofolate reductase:thymidylate synthase activity" EXACT [EC:1.5.1.3]
synonym: "dihydrofolate reduction" EXACT []
synonym: "dihydrofolic acid reductase activity" EXACT [EC:1.5.1.3]
synonym: "dihydrofolic reductase activity" EXACT [EC:1.5.1.3]
synonym: "folic acid reductase activity" EXACT [EC:1.5.1.3]
synonym: "folic reductase activity" EXACT [EC:1.5.1.3]
synonym: "NADPH-dihydrofolate reductase activity" EXACT [EC:1.5.1.3]
synonym: "pteridine reductase:dihydrofolate reductase activity" EXACT [EC:1.5.1.3]
synonym: "tetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.3]
synonym: "thymidylate synthetase-dihydrofolate reductase activity" EXACT [EC:1.5.1.3]
xref: EC:1.5.1.3
xref: MetaCyc:DIHYDROFOLATEREDUCT-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004147
name: dihydrolipoamide branched chain acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide, where the acyl group is a branched chain." [GOC:mah]
subset: gosubset_prok
synonym: "dihydrolipoamide branched chain transacylase activity" EXACT []
xref: EC:2.3.1.-
xref: Reactome:8394 "dihydrolipoamide branched chain acyltransferase activity"
is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity

[Term]
id: GO:0004148
name: dihydrolipoyl dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4]
subset: gosubset_prok
synonym: "dehydrolipoate dehydrogenase activity" EXACT [EC:1.8.1.4]
synonym: "diaphorase activity" EXACT [EC:1.8.1.4]
synonym: "dihydrolipoamide dehydrogenase activity" EXACT [EC:1.8.1.4]
synonym: "dihydrolipoamide reduction" RELATED [EC:1.8.1.4]
synonym: "dihydrolipoamide:NAD+ oxidoreductase" EXACT [EC:1.8.1.4]
synonym: "dihydrolipoic dehydrogenase activity" EXACT [EC:1.8.1.4]
synonym: "dihydrolipoylprotein reduction" RELATED [EC:1.8.1.4]
synonym: "dihydrothioctic dehydrogenase activity" EXACT [EC:1.8.1.4]
synonym: "E3 component of alpha-ketoacid dehydrogenase complexes activity" RELATED [EC:1.8.1.4]
synonym: "glycine-cleavage system L-protein activity" RELATED [EC:1.8.1.4]
synonym: "L-protein activity" RELATED [EC:1.8.1.4]
synonym: "LDP-Glc activity" NARROW [EC:1.8.1.4]
synonym: "LDP-Val activity" NARROW [EC:1.8.1.4]
synonym: "lipoamide dehydrogenase (NADH) activity" EXACT [EC:1.8.1.4]
synonym: "lipoamide oxidoreductase (NADH) activity" EXACT [EC:1.8.1.4]
synonym: "lipoamide reductase (NADH) activity" EXACT [EC:1.8.1.4]
synonym: "lipoamide reductase activity" EXACT [EC:1.8.1.4]
synonym: "lipoate dehydrogenase activity" EXACT [EC:1.8.1.4]
synonym: "lipoic acid dehydrogenase activity" EXACT [EC:1.8.1.4]
synonym: "lipoyl dehydrogenase activity" EXACT [EC:1.8.1.4]
synonym: "protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4]
synonym: "protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4]
xref: EC:1.8.1.4
xref: MetaCyc:DIHYDLIPOXN-RXN
xref: Reactome:8399 "dihydrolipoyl dehydrogenase activity"
is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004149
name: dihydrolipoyllysine-residue succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide." [EC:2.3.1.61]
subset: gosubset_prok
synonym: "dihydrolipoamide S-succinyltransferase activity" EXACT []
synonym: "dihydrolipoamide succinyltransferase activity" EXACT [EC:2.3.1.61]
synonym: "dihydrolipoic transsuccinylase activity" EXACT [EC:2.3.1.61]
synonym: "dihydrolipolyl transsuccinylase activity" EXACT [EC:2.3.1.61]
synonym: "dihydrolipoyl transsuccinylase activity" EXACT [EC:2.3.1.61]
synonym: "enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity" EXACT [EC:2.3.1.61]
synonym: "lipoate succinyltransferase (Escherichia coli) activity" EXACT [EC:2.3.1.61]
synonym: "lipoate succinyltransferase activity" EXACT [EC:2.3.1.61]
synonym: "lipoic transsuccinylase activity" EXACT [EC:2.3.1.61]
synonym: "lipoyl transsuccinylase activity" EXACT [EC:2.3.1.61]
synonym: "succinyl-CoA:dihydrolipoamide S-succinyltransferase activity" EXACT [EC:2.3.1.61]
synonym: "succinyl-CoA:dihydrolipoate S-succinyltransferase activity" EXACT [EC:2.3.1.61]
synonym: "succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61]
synonym: "succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61]
xref: EC:2.3.1.61
xref: Reactome:8404 "dihydrolipoyllysine-residue succinyltransferase activity"
is_a: GO:0016751 ! S-succinyltransferase activity

[Term]
id: GO:0004150
name: dihydroneopterin aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde." [EC:4.1.2.25]
subset: gosubset_prok
synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)" EXACT [EC:4.1.2.25]
synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity" EXACT [EC:4.1.2.25]
xref: EC:4.1.2.25
xref: MetaCyc:H2NEOPTERINALDOL-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0004151
name: dihydroorotase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate." [EC:3.5.2.3]
subset: gosubset_prok
synonym: "(S)-dihydroorotate amidohydrolase activity" EXACT [EC:3.5.2.3]
synonym: "carbamoylaspartic dehydrase activity" EXACT [EC:3.5.2.3]
synonym: "DHOase activity" EXACT [EC:3.5.2.3]
synonym: "dihydroorotate hydrolase activity" EXACT [EC:3.5.2.3]
xref: EC:3.5.2.3
xref: MetaCyc:DIHYDROOROT-RXN
xref: Reactome:8410 "dihydroorotase activity"
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0004152
name: dihydroorotate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor." [EC:1.3.99.11]
subset: gosubset_prok
synonym: "(DHO) dehydrogenase activity" RELATED [EC:1.3.3.1]
synonym: "(S)-dihydroorotate:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.11]
synonym: "(S)-dihydroorotate:acceptor oxidoreductase activity" EXACT [EC:1.3.99.11]
synonym: "DHOdehase activity" EXACT [EC:1.3.3.1]
synonym: "dihydoorotic acid dehydrogenase activity" EXACT [EC:1.3.3.1]
synonym: "dihydroorotate:ubiquinone oxidoreductase activity" NARROW [EC:1.3.99.11]
xref: EC:1.3.99.11
xref: MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN
xref: Reactome:8412 "dihydroorotate dehydrogenase activity"
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0004153
name: dihydropterin deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydropterin + H20 = 7,8-dihydrolumazine + NH3." [FB:FBrf0039640, GOC:jl, http://www.abbs.info/fulltxt/eng/35030306.htm, ISSN:05829879]
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004154
name: dihydropterin oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + H2O2." [GOC:mah, PMID:1745247, PMID:6815189]
xref: EC:1.5.3.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0004155
name: 6,7-dihydropteridine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine." [EC:1.5.1.34]
comment: Note that this function was formerly EC:1.6.99.7.
subset: gosubset_prok
synonym: "5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.34]
synonym: "5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity" EXACT [EC:1.5.1.34]
synonym: "6,7-dihydropteridine:NAD(P)H oxidoreductase activity" EXACT [EC:1.5.1.34]
synonym: "DHPR activity" EXACT [EC:1.5.1.34]
synonym: "dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.5.1.34]
synonym: "dihydropteridine reductase (NADH) activity" EXACT [EC:1.5.1.34]
synonym: "dihydropteridine reductase activity" EXACT []
synonym: "dihydropteridine reduction" RELATED []
synonym: "NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34]
synonym: "NAD(P)H2:6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34]
synonym: "NADH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34]
synonym: "NADPH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34]
synonym: "NADPH-specific dihydropteridine reductase activity" EXACT [EC:1.5.1.34]
xref: EC:1.5.1.34
xref: MetaCyc:1.5.1.34-RXN
xref: Reactome:8421 "6,7-dihydropteridine reductase activity"
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004156
name: dihydropteroate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate." [EC:2.5.1.15]
subset: gosubset_prok
synonym: "(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15]
synonym: "2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15]
synonym: "7,8-dihydropteroate synthase activity" EXACT [EC:2.5.1.15]
synonym: "7,8-dihydropteroate synthetase activity" EXACT [EC:2.5.1.15]
synonym: "7,8-dihydropteroic acid synthetase activity" EXACT [EC:2.5.1.15]
synonym: "DHPS activity" EXACT [EC:2.5.1.15]
synonym: "dihydropteroate diphosphorylase activity" EXACT [EC:2.5.1.15]
synonym: "dihydropteroate pyrophosphorylase activity" EXACT [EC:2.5.1.15]
synonym: "dihydropteroate synthetase activity" EXACT [EC:2.5.1.15]
synonym: "dihydropteroic synthetase activity" EXACT [EC:2.5.1.15]
xref: EC:2.5.1.15
xref: MetaCyc:H2PTEROATESYNTH-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004157
name: dihydropyrimidinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate." [EC:3.5.2.2]
subset: gosubset_prok
synonym: "5,6-dihydropyrimidine amidohydrolase activity" EXACT [EC:3.5.2.2]
synonym: "D-hydantoinase activity" EXACT [EC:3.5.2.2]
synonym: "hydantoin peptidase activity" EXACT [EC:3.5.2.2]
synonym: "hydantoinase activity" EXACT [EC:3.5.2.2]
synonym: "hydropyrimidine hydrase activity" EXACT [EC:3.5.2.2]
synonym: "pyrimidine hydrase activity" EXACT [EC:3.5.2.2]
xref: EC:3.5.2.2
xref: MetaCyc:DIHYDROPYRIMIDINASE-RXN
xref: Reactome:8430 "dihydropyrimidinase activity"
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0004158
name: dihydroorotate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + O2 = orotate + H2O2." [EC:1.3.3.1]
subset: gosubset_prok
synonym: "(S)-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1]
synonym: "4,5-L-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1]
xref: EC:1.3.3.1
xref: MetaCyc:DIHYDROOROTOX-RXN
is_a: GO:0004152 ! dihydroorotate dehydrogenase activity
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0004159
name: dihydrouracil dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydrouracil + NAD+ = uracil + NADH + H+." [EC:1.3.1.1]
synonym: "5,6-dihydrouracil:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.1]
synonym: "dehydrogenase, dihydrouracil" EXACT [EC:1.3.1.1]
synonym: "pyrimidine reductase activity" EXACT [EC:1.3.1.1]
synonym: "thymine reductase activity" EXACT [EC:1.3.1.1]
synonym: "uracil reductase activity" EXACT [EC:1.3.1.1]
xref: EC:1.3.1.1
xref: MetaCyc:DIHYDROURACIL-DEHYDROGENASE-NAD+-RXN
xref: Reactome:8435 "dihydrouracil dehydrogenase (NAD+) activity"
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004160
name: dihydroxy-acid dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O." [EC:4.2.1.9]
subset: gosubset_prok
synonym: "2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)" EXACT [EC:4.2.1.9]
synonym: "2,3-dihydroxy-acid hydro-lyase activity" EXACT [EC:4.2.1.9]
synonym: "2,3-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9]
synonym: "acetohydroxyacid dehydratase activity" EXACT [EC:4.2.1.9]
synonym: "alpha,beta-dihydroxyacid dehydratase activity" EXACT [EC:4.2.1.9]
synonym: "alpha,beta-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9]
synonym: "DHAD" RELATED [EC:4.2.1.9]
synonym: "dihydroxy acid dehydrase activity" EXACT [EC:4.2.1.9]
xref: EC:4.2.1.9
xref: MetaCyc:DIHYDROXYISOVALDEHYDRAT-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004161
name: dimethylallyltranstransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate." [EC:2.5.1.1]
comment: Note that this is the first step in the formation of farnesyl diphosphate. The second step is 'geranyltranstransferase activity ; GO:0004337'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'.
subset: gosubset_prok
synonym: "(2E,6E)-farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.1]
synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity" EXACT [EC:2.5.1.1]
synonym: "dimethylallyltransferase activity" EXACT []
synonym: "diprenyltransferase activity" EXACT [EC:2.5.1.1]
synonym: "DMAPP:IPP-dimethylallyltransferase activity" EXACT [EC:2.5.1.1]
synonym: "geranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.1]
synonym: "geranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1]
synonym: "geranyl-diphosphate synthase activity" RELATED [EC:2.5.1.1]
synonym: "trans-farnesyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1]
xref: EC:2.5.1.1
xref: MetaCyc:GPPSYN-RXN
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0004162
name: dimethylnitrosamine demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from N-nitrosodimethylamine." [GOC:mah]
synonym: "N-nitrosodimethylamine demethylase activity" EXACT []
is_a: GO:0032451 ! demethylase activity

[Term]
id: GO:0004163
name: diphosphomevalonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2." [EC:4.1.1.33]
subset: gosubset_prok
synonym: "5-pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33]
synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)" EXACT [EC:4.1.1.33]
synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)" EXACT [EC:4.1.1.33]
synonym: "mevalonate 5-diphosphate decarboxylase activity" EXACT [EC:4.1.1.33]
synonym: "mevalonate diphosphate decarboxylase activity" EXACT [EC:4.1.1.33]
synonym: "mevalonate pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33]
synonym: "mevalonate-5-pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33]
synonym: "pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33]
synonym: "pyrophosphomevalonic acid decarboxylase activity" EXACT [EC:4.1.1.33]
xref: EC:4.1.1.33
xref: MetaCyc:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN
xref: Reactome:8449 "diphosphomevalonate decarboxylase activity"
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004164
name: diphthine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine." [EC:2.1.1.98]
subset: gosubset_prok
synonym: "diphthine methyltransferase activity" EXACT [EC:2.1.1.98]
synonym: "S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity" EXACT [EC:2.1.1.98]
synonym: "S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity" EXACT [EC:2.1.1.98]
xref: EC:2.1.1.98
xref: MetaCyc:DIPHTHINE-SYNTHASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004165
name: dodecenoyl-CoA delta-isomerase activity
namespace: molecular_function
alt_id: GO:0008461
def: "Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA." [EC:5.3.3.8]
subset: gosubset_prok
synonym: "3,2-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8]
synonym: "acetylene-allene isomerase activity" EXACT [EC:5.3.3.8]
synonym: "delta(3),Delta(2)-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8]
synonym: "delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8]
synonym: "delta3,Delta2-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8]
synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.8]
synonym: "dodecenoyl-CoA (3Z)-(2E)-isomerase activity" EXACT [EC:5.3.3.8]
synonym: "dodecenoyl-CoA D-isomerase activity" EXACT []
synonym: "dodecenoyl-CoA Delta-isomerase activity" EXACT [EC:5.3.3.8]
synonym: "dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity" EXACT [EC:5.3.3.8]
synonym: "dodecenoyl-CoA isomerase activity" EXACT [EC:5.3.3.8]
xref: EC:5.3.3.8
xref: MetaCyc:ENOYL-COA-DELTA-ISOM-RXN
xref: Reactome:8459 "dodecenoyl-CoA delta-isomerase activity"
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0004166
name: dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity
namespace: molecular_function
alt_id: GO:0004101
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate." [EC:2.4.1.153]
synonym: "dolichyl phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153]
synonym: "dolichyl phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153]
synonym: "dolichyl-phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153]
synonym: "dolichyl-phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153]
synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.153]
synonym: "UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153]
synonym: "uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153]
xref: EC:2.4.1.153
xref: MetaCyc:2.4.1.153-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0004167
name: dopachrome isomerase activity
namespace: molecular_function
alt_id: GO:0048059
def: "Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate." [EC:5.3.3.12]
synonym: "DCF activity" EXACT [EC:5.3.3.12]
synonym: "DCT activity" EXACT [EC:5.3.3.12]
synonym: "dopachrome conversion activity" BROAD []
synonym: "dopachrome conversion factor activity" BROAD [EC:5.3.3.12]
synonym: "dopachrome Delta(7),Delta(2)-isomerase activity" EXACT [EC:5.3.3.12]
synonym: "dopachrome delta-isomerase activity" EXACT []
synonym: "dopachrome delta7,Delta2-isomerase activity" EXACT [EC:5.3.3.12]
synonym: "dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12]
synonym: "dopachrome oxidoreductase activity" EXACT [EC:5.3.3.12]
synonym: "dopachrome rearranging enzyme activity" EXACT [EC:5.3.3.12]
synonym: "dopachrome tautomerase activity" EXACT [EC:5.3.3.12]
synonym: "dopachrome-rearranging enzyme" RELATED [EC:5.3.3.12]
synonym: "L-dopachrome isomerase activity" EXACT [EC:5.3.3.12]
synonym: "L-dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12]
synonym: "L-dopachrome-methyl ester tautomerase activity" EXACT [EC:5.3.3.12]
synonym: "TRP activity" EXACT [EC:5.3.3.12]
synonym: "TRP-1" RELATED [EC:5.3.3.12]
synonym: "TRP-2" RELATED [EC:5.3.3.12]
synonym: "TRP2" RELATED [EC:5.3.3.12]
synonym: "tryosinase-related protein-2" RELATED [EC:5.3.3.12]
synonym: "tyrosinase-related protein 2 activity" EXACT [EC:5.3.3.12]
xref: EC:5.3.3.12
xref: MetaCyc:DOPACHROME-DELTA-ISOMERASE-RXN
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0004168
name: dolichol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate." [EC:2.7.1.108]
synonym: "CTP:dolichol O-phosphotransferase activity" EXACT [EC:2.7.1.108]
synonym: "dolichol phosphokinase activity" EXACT [EC:2.7.1.108]
xref: EC:2.7.1.108
xref: MetaCyc:DOLICHOL-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004169
name: dolichyl-phosphate-mannose-protein mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109]
subset: gosubset_prok
synonym: "dolichol phosphomannose-protein mannosyltransferase activity" EXACT [EC:2.4.1.109]
synonym: "dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109]
synonym: "dolichyl-phosphate-mannose-protein O-mannosyltransferase activity" EXACT []
synonym: "O-glycoside mannosyltransferase" BROAD []
synonym: "protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109]
synonym: "protein O-mannosyltransferase activity" EXACT []
xref: EC:2.4.1.109
xref: MetaCyc:2.4.1.109-RXN
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0004170
name: dUTP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate." [EC:3.6.1.23]
subset: gosubset_prok
synonym: "deoxyuridine-triphosphatase activity" EXACT [EC:3.6.1.23]
synonym: "desoxyuridine 5'-triphosphatase activity" EXACT [EC:3.6.1.23]
synonym: "desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.23]
synonym: "dUTP nucleotidohydrolase activity" EXACT [EC:3.6.1.23]
synonym: "dUTP pyrophosphatase activity" EXACT []
synonym: "dUTPase activity" EXACT [EC:3.6.1.23]
xref: EC:3.6.1.23
xref: MetaCyc:DUTP-PYROP-RXN
xref: Reactome:8479 "dUTP diphosphatase activity"
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity

[Term]
id: GO:0004171
name: deoxyhypusine synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine." [EC:2.5.1.46]
comment: This term was made obsolete because it represents a multistep reaction.
synonym: "[eIF-5A]-deoxyhypusine synthase" RELATED []
is_obsolete: true
replaced_by: GO:0008612
replaced_by: GO:0034038
replaced_by: GO:0050983

[Term]
id: GO:0004172
name: ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents two molecular functions.
is_obsolete: true
consider: GO:0050488

[Term]
id: GO:0004173
name: ecdysone O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + ecdysone = CoA + ecdysone palmitate." [EC:2.3.1.139]
synonym: "acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139]
synonym: "fatty acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139]
synonym: "palmitoyl-CoA:ecdysone palmitoyltransferase activity" EXACT [EC:2.3.1.139]
xref: EC:2.3.1.139
xref: MetaCyc:ECDYSONE-O-ACYLTRANSFERASE-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0004174
name: electron-transferring-flavoprotein dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol." [EC:1.5.5.1]
subset: gosubset_prok
synonym: "electron transfer flavoprotein dehydrogenase activity" EXACT [EC:1.5.5.1]
synonym: "electron transfer flavoprotein Q oxidoreductase activity" EXACT [EC:1.5.5.1]
synonym: "electron transfer flavoprotein reductase activity" EXACT [EC:1.5.5.1]
synonym: "electron transfer flavoprotein-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1]
synonym: "electron-transferring-flavoprotein:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1]
synonym: "ETF dehydrogenase activity" EXACT [EC:1.5.5.1]
synonym: "ETF-QO activity" EXACT [EC:1.5.5.1]
synonym: "ETF-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1]
synonym: "ETF:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1]
xref: EC:1.5.5.1
xref: MetaCyc:1.5.5.1-RXN
xref: Reactome:8494 "electron-transferring-flavoprotein dehydrogenase activity"
is_a: GO:0016649 ! oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0004175
name: endopeptidase activity
namespace: molecular_function
alt_id: GO:0016809
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE]
subset: gosubset_prok
synonym: "endoprotease activity" EXACT []
synonym: "proteasome endopeptidase activity" NARROW []
synonym: "proteasome endopeptidase regulator" RELATED []
synonym: "proteinase" BROAD []
xref: Reactome:1793 "endopeptidase activity"
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0004176
name: ATP-dependent peptidase activity
namespace: molecular_function
alt_id: GO:0004280
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds." [GOC:mah]
subset: gosubset_prok
synonym: "ATP-dependent proteolysis" RELATED [GOC:mah]
is_a: GO:0042623 ! ATPase activity, coupled
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0004177
name: aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: EC:3.4.11
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0004178
name: leucyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro." [EC:3.4.11.1]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "aminopeptidase II" RELATED [EC:3.4.11.1]
synonym: "cathepsin III" RELATED [EC:3.4.11.1]
synonym: "cytosol aminopeptidase activity" NARROW [EC:3.4.11.1]
synonym: "FTBL proteins" RELATED [EC:3.4.11.1]
synonym: "L-leucine aminopeptidase activity" EXACT [EC:3.4.11.1]
synonym: "leucinamide aminopeptidase activity" EXACT [EC:3.4.11.1]
synonym: "leucinaminopeptidase activity" EXACT [EC:3.4.11.1]
synonym: "leucine aminopeptidase activity" EXACT [EC:3.4.11.1]
synonym: "leucyl peptidase activity" EXACT [EC:3.4.11.1]
synonym: "peptidase S activity" NARROW [EC:3.4.11.1]
synonym: "proteinates FTBL" RELATED [EC:3.4.11.1]
xref: EC:3.4.11.1
xref: MetaCyc:3.4.11.1-RXN
is_obsolete: true
replaced_by: GO:0004177
replaced_by: GO:0008235

[Term]
id: GO:0004179
name: membrane alanyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide." [EC:3.4.11.2]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "alanine-specific aminopeptidase activity" EXACT [EC:3.4.11.2]
synonym: "alanyl aminopeptidase activity" EXACT [EC:3.4.11.2]
synonym: "amino-oligopeptidase activity" EXACT [EC:3.4.11.2]
synonym: "aminopeptidase M activity" NARROW [EC:3.4.11.2]
synonym: "aminopeptidase N activity" NARROW [EC:3.4.11.2]
synonym: "CD13" RELATED [EC:3.4.11.2]
synonym: "cysteinylglycinase activity" EXACT [EC:3.4.11.2]
synonym: "cysteinylglycine dipeptidase activity" EXACT [EC:3.4.11.2]
synonym: "L-alanine aminopeptidase activity" EXACT [EC:3.4.11.2]
synonym: "membrane alanine aminopeptidase activity" NARROW [EC:3.4.11.2]
synonym: "membrane aminopeptidase I activity" NARROW [EC:3.4.11.2]
synonym: "microsomal aminopeptidase activity" NARROW [EC:3.4.11.2]
synonym: "particle-bound aminopeptidase activity" NARROW [EC:3.4.11.2]
synonym: "peptidase E activity" BROAD [EC:3.4.11.2]
synonym: "pseudo leucine aminopeptidase activity" EXACT [EC:3.4.11.2]
xref: EC:3.4.11.2
xref: MetaCyc:3.4.11.2-RXN
is_obsolete: true
replaced_by: GO:0004177
replaced_by: GO:0008235

[Term]
id: GO:0004180
name: carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0004181
name: metallocarboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/about_9.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: EC:3.4.17
xref: Reactome:8516 "metallocarboxypeptidase activity"
is_a: GO:0004180 ! carboxypeptidase activity
is_a: GO:0008235 ! metalloexopeptidase activity

[Term]
id: GO:0004182
name: carboxypeptidase A activity
namespace: molecular_function
alt_id: GO:0008731
def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro." [EC:3.4.17.1]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "carboxypolypeptidase activity" EXACT [EC:3.4.17.1]
synonym: "pancreatic carboxypeptidase A" RELATED [EC:3.4.17.1]
synonym: "tissue carboxypeptidase A" RELATED [EC:3.4.17.1]
xref: EC:3.4.17.1
xref: MetaCyc:CARBOXYPEPTIDASE-A-RXN
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0004183
name: carboxypeptidase E activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents." [EC:3.4.17.10]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase H activity" EXACT []
synonym: "cobalt-stimulated chromaffin granule carboxypeptidase activity" EXACT [EC:3.4.17.10]
synonym: "enkephalin convertase activity" NARROW [EC:3.4.17.10]
synonym: "enkephalin precursor carboxypeptidase activity" EXACT [EC:3.4.17.10]
synonym: "enkephalin-precursor endopeptidase activity" EXACT [EC:3.4.17.10]
synonym: "insulin granule-associated carboxypeptidase activity" EXACT [EC:3.4.17.10]
synonym: "membrane-bound carboxypeptidase activity" EXACT [EC:3.4.17.10]
synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.10]
xref: EC:3.4.17.10
xref: MetaCyc:CARBOXYPEPTIDASE-H-RXN
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0004184
name: lysine carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma." [EC:3.4.17.3]
comment: This term was made obsolete because it represents a gene product.
synonym: "anaphylatoxin inactivator activity" NARROW [EC:3.4.17.3]
synonym: "arginine carboxypeptidase activity" EXACT [EC:3.4.17.3]
synonym: "bradykinase activity" EXACT [EC:3.4.17.3]
synonym: "bradykinin-decomposing enzyme" RELATED [EC:3.4.17.3]
synonym: "carboxypeptidase N activity" EXACT []
synonym: "CPase N" RELATED [EC:3.4.17.3]
synonym: "creatine kinase conversion factor" RELATED [EC:3.4.17.3]
synonym: "creatinine kinase convertase activity" EXACT [EC:3.4.17.3]
synonym: "hippuryllysine hydrolase activity" EXACT [EC:3.4.17.3]
synonym: "kininase I activity" EXACT [EC:3.4.17.3]
synonym: "kininase Ia" RELATED [EC:3.4.17.3]
synonym: "lysine (arginine) carboxypeptidase activity" EXACT []
synonym: "lysine(arginine) carboxypeptidase activity" EXACT [EC:3.4.17.3]
synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.3]
synonym: "plasma carboxypeptidase B" RELATED [EC:3.4.17.3]
xref: EC:3.4.17.3
xref: MetaCyc:LYSINEARGININE-CARBOXYPEPTIDASE-RXN
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0004185
name: serine-type carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/about_9.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, ISBN:0716720094]
subset: gosubset_prok
synonym: "serine carboxypeptidase activity" EXACT []
xref: EC:3.4.16
xref: Reactome:8533 "serine-type carboxypeptidase activity"
is_a: GO:0004180 ! carboxypeptidase activity
is_a: GO:0070008 ! serine-type exopeptidase activity

[Term]
id: GO:0004186
name: carboxypeptidase C activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase Y activity" EXACT [EC:3.4.16.5]
synonym: "cathepsin A activity" NARROW [EC:3.4.16.5]
synonym: "deamidase" RELATED [EC:3.4.16.5]
synonym: "lysosomal carboxypeptidase A" NARROW [EC:3.4.16.5]
synonym: "lysosomal protective protein activity" NARROW [EC:3.4.16.5]
synonym: "serine carboxypeptidase I activity" EXACT [EC:3.4.16.5]
synonym: "serine-type carboxypeptidase I activity" EXACT [EC:3.4.16.5]
synonym: "vacuolar carboxypeptidase Y" NARROW []
xref: EC:3.4.16.5
xref: MetaCyc:3.4.16.5-RXN
is_obsolete: true
replaced_by: GO:0004185

[Term]
id: GO:0004187
name: carboxypeptidase D activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents." [EC:3.4.16.6]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase Kex1" RELATED [EC:3.4.16.6]
synonym: "carboxypeptidase KEX1 activity" NARROW [EC:3.4.16.6]
synonym: "carboxypeptidase S1 activity" EXACT [EC:3.4.16.6]
synonym: "cereal serine carboxypeptidase II" RELATED [EC:3.4.16.6]
synonym: "CPDW-II" RELATED [EC:3.4.16.6]
synonym: "gene KEX1 serine carboxypeptidase" NARROW [EC:3.4.16.6]
synonym: "KEX1 carboxypeptidase activity" EXACT [EC:3.4.16.6]
synonym: "KEX1 proteinase activity" EXACT [EC:3.4.16.6]
synonym: "KEX1DELTAp" RELATED [EC:3.4.16.6]
synonym: "saccharomyces cerevisiae KEX1 gene product" RELATED [EC:3.4.16.6]
xref: EC:3.4.16.6
xref: MetaCyc:3.4.16.6-RXN
is_obsolete: true
replaced_by: GO:0004185

[Term]
id: GO:0004188
name: serine-type Pro-X carboxypeptidase activity
namespace: molecular_function
alt_id: GO:0008323
def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid." [EC:3.4.16.2]
comment: This term was made obsolete because it represents a gene product.
synonym: "aminoacylproline carboxypeptidase activity" EXACT [EC:3.4.16.2]
synonym: "angiotensinase C activity" NARROW [EC:3.4.16.2]
synonym: "lysosomal carboxypeptidase C activity" NARROW [EC:3.4.16.2]
synonym: "lysosomal Pro-X carboxypeptidase activity" NARROW []
synonym: "lysosomal Pro-Xaa carboxypeptidase activity" EXACT [EC:3.4.16.2]
synonym: "PCP" RELATED [EC:3.4.16.2]
synonym: "peptidylprolylamino acid carboxypeptidase activity" EXACT [EC:3.4.16.2]
synonym: "proline carboxypeptidase activity" EXACT [EC:3.4.16.2]
synonym: "proline-specific carboxypeptidase P" RELATED [EC:3.4.16.2]
synonym: "prolyl carboxypeptidase activity" EXACT [EC:3.4.16.2]
xref: EC:3.4.16.2
xref: MetaCyc:3.4.16.2-RXN
is_obsolete: true
replaced_by: GO:0004185

[Term]
id: GO:0004189
name: tubulinyl-Tyr carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr." [EC:3.4.17.17]
comment: This term was made obsolete because it represents a gene product.
synonym: "brain I carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "carboxypeptidase-tubulin activity" EXACT [EC:3.4.17.17]
synonym: "soluble carboxypeptidase activity" RELATED [EC:3.4.17.17]
synonym: "TTCPase activity" EXACT [EC:3.4.17.17]
synonym: "tubulin carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "tubulin-tyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "tubulinyl-tyrosine carboxypeptidase activity" EXACT []
synonym: "tubulinyltyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "tyrosinotubulin carboxypeptidase activity" EXACT [EC:3.4.17.17]
synonym: "tyrosyltubulin carboxypeptidase activity" EXACT [EC:3.4.17.17]
xref: EC:3.4.17.17
xref: MetaCyc:3.4.17.17-RXN
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0004190
name: aspartic-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aspartic endopeptidase activity" EXACT []
synonym: "aspartic protease activity" EXACT []
synonym: "aspartyl protease activity" EXACT []
synonym: "carboxyl protease activity" EXACT []
xref: EC:3.4.23
xref: Reactome:1933 "aspartic-type endopeptidase activity"
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0070001 ! aspartic-type peptidase activity

[Term]
id: GO:0004191
name: barrierpepsin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor." [EC:3.4.23.35]
comment: This term was made obsolete because it represents a gene product.
synonym: "Bar proteinase activity" NARROW [EC:3.4.23.35]
synonym: "barrier proteinase activity" EXACT [EC:3.4.23.35]
synonym: "extracellular 'barrier' protein activity" RELATED [EC:3.4.23.35]
xref: EC:3.4.23.35
xref: MetaCyc:3.4.23.35-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004192
name: cathepsin D activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin." [EC:3.4.23.5]
comment: This term was made obsolete because it represents a gene product.
xref: EC:3.4.23.5
xref: MetaCyc:3.4.23.5-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004193
name: cathepsin E activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity." [EC:3.4.23.34]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin D-like acid proteinase activity" EXACT [EC:3.4.23.34]
synonym: "cathepsin D-type proteinase activity" EXACT [EC:3.4.23.34]
synonym: "cathepsin E-like acid proteinase activity" EXACT [EC:3.4.23.34]
synonym: "EMAP" RELATED [EC:3.4.23.34]
synonym: "erythrocyte membrane aspartic proteinase activity" NARROW [EC:3.4.23.34]
synonym: "non-pepsin proteinase activity" EXACT [EC:3.4.23.34]
synonym: "slow-moving proteinase activity" RELATED [EC:3.4.23.34]
synonym: "SMP" RELATED [EC:3.4.23.34]
xref: EC:3.4.23.34
xref: MetaCyc:3.4.23.34-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004194
name: pepsin A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin." [EC:3.4.23.1]
comment: This term was made obsolete because it represents a gene product.
synonym: "elixir lactate of pepsin" RELATED [EC:3.4.23.1]
synonym: "fundus-pepsin" RELATED [EC:3.4.23.1]
synonym: "lactated pepsin" RELATED [EC:3.4.23.1]
synonym: "lactated pepsin elixir" RELATED [EC:3.4.23.1]
synonym: "P I" RELATED [EC:3.4.23.1]
synonym: "P II" RELATED [EC:3.4.23.1]
synonym: "pepsin activity" BROAD [EC:3.4.23.1]
synonym: "pepsin D" RELATED [EC:3.4.23.1]
synonym: "pepsin fortior" RELATED [EC:3.4.23.1]
synonym: "pepsin R" RELATED [EC:3.4.23.1]
xref: EC:3.4.23.1
xref: MetaCyc:3.4.23.1-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004195
name: renin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I." [EC:3.4.23.15]
comment: This term was made obsolete because it represents a gene product.
synonym: "angiotensin-forming enzyme activity" EXACT [EC:3.4.23.15]
synonym: "angiotensinogenase activity" EXACT [EC:3.4.23.15]
xref: EC:3.4.23.15
xref: MetaCyc:3.4.23.15-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004196
name: saccharopepsin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24." [EC:3.4.23.25]
comment: This term was made obsolete because it represents a gene product.
synonym: "aspartic proteinase yscA" RELATED [EC:3.4.23.25]
synonym: "PRA" RELATED [EC:3.4.23.25]
synonym: "proteinase A" RELATED [EC:3.4.23.25]
synonym: "proteinase yscA" RELATED [EC:3.4.23.25]
synonym: "saccharomyces aspartic proteinase activity" EXACT [EC:3.4.23.25]
synonym: "Saccharomyces aspartic proteinase activity" NARROW [EC:3.4.23.25]
synonym: "saccharomyces cerevisiae aspartic proteinase A" RELATED [EC:3.4.23.25]
synonym: "yeast endopeptidase A activity" NARROW [EC:3.4.23.25]
synonym: "yeast proteinase A" RELATED [EC:3.4.23.25]
xref: EC:3.4.23.25
xref: MetaCyc:3.4.23.25-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0004197
name: cysteine-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE]
subset: gosubset_prok
synonym: "lysosomal cysteine-type endopeptidase" NARROW []
synonym: "thiol endopeptidase activity" EXACT []
xref: EC:3.4.22
xref: Reactome:4344 "cysteine-type endopeptidase activity"
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0008234 ! cysteine-type peptidase activity

[Term]
id: GO:0004198
name: calcium-dependent cysteine-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]
subset: gosubset_prok
synonym: "calpain activity" NARROW []
is_a: GO:0004197 ! cysteine-type endopeptidase activity

[Term]
id: GO:0004200
name: signaling (initiator) caspase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes biological process information.
synonym: "signalling (initiator) caspase activity" EXACT []
is_obsolete: true
replaced_by: GO:0004197
consider: GO:0006915

[Term]
id: GO:0004201
name: caspase-1 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this function can also hydrolyze the terminal bond in the small-molecule substrate, Ac-Tyr-Val-Ala-Asp-NHMec." [EC:3.4.22.36]
comment: This term was made obsolete because it represents a gene product.
synonym: "ICE" BROAD []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004202
name: caspase-2 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004203
name: caspase-4 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004204
name: caspase-5 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004205
name: caspase-8 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004206
name: caspase-10 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004207
name: effector caspase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes biological process information.
is_obsolete: true
replaced_by: GO:0004197
consider: GO:0006915

[Term]
id: GO:0004208
name: caspase-3 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis." [ISBN:0120793709]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004209
name: caspase-6 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004210
name: caspase-7 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004211
name: caspase-9 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004212
name: lysosomal cysteine-type endopeptidase
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
is_obsolete: true
consider: GO:0004197
consider: GO:0005764

[Term]
id: GO:0004213
name: cathepsin B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides." [EC:3.4.22.1]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin B1 activity" EXACT [EC:3.4.22.1]
synonym: "cathepsin II" RELATED [EC:3.4.22.1]
xref: EC:3.4.22.1
xref: MetaCyc:3.4.22.1-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004214
name: dipeptidyl-peptidase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro." [EC:3.4.14.1]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin C activity" EXACT [EC:3.4.14.1]
synonym: "cathepsin J activity" EXACT [EC:3.4.14.1]
synonym: "DAP I" RELATED [EC:3.4.14.1]
synonym: "dipeptide arylamidase I" RELATED [EC:3.4.14.1]
synonym: "dipeptidyl aminopeptidase I activity" EXACT [EC:3.4.14.1]
synonym: "dipeptidyl transferase activity" EXACT [EC:3.4.14.1]
xref: EC:3.4.14.1
xref: MetaCyc:3.4.14.1-RXN
is_obsolete: true
replaced_by: GO:0008234
replaced_by: GO:0008239

[Term]
id: GO:0004215
name: cathepsin H activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase." [EC:3.4.22.16]
comment: This term was made obsolete because it represents a gene product.
synonym: "aleurain activity" EXACT [EC:3.4.22.16]
synonym: "benzoylarginine-naphthylamide (BANA) hydrolase activity" EXACT [EC:3.4.22.16]
synonym: "cathepsin B3 activity" EXACT [EC:3.4.22.16]
synonym: "cathepsin Ba" RELATED [EC:3.4.22.16]
synonym: "cathepsin BA activity" EXACT [EC:3.4.22.16]
synonym: "N-benzoylarginine-beta-naphthylamide hydrolase activity" EXACT [EC:3.4.22.16]
xref: EC:3.4.22.16
xref: MetaCyc:3.4.22.16-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004216
name: cathepsin K activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg." [EC:3.4.22.38]
comment: This term was made obsolete because it represents a gene product.
synonym: "cathepsin O activity" EXACT [EC:3.4.22.38]
synonym: "cathepsin O2 activity" EXACT [EC:3.4.22.38]
synonym: "cathepsin X activity" EXACT [EC:3.4.22.38]
xref: EC:3.4.22.38
xref: MetaCyc:3.4.22.38-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004217
name: cathepsin L activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity." [EC:3.4.22.15]
comment: This term was made obsolete because it represents a gene product.
synonym: "Aldrichina grahami cysteine proteinase" NARROW [EC:3.4.22.15]
xref: EC:3.4.22.15
xref: MetaCyc:3.4.22.15-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004218
name: cathepsin S activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds." [EC:3.4.22.27]
comment: This term was made obsolete because it represents a gene product.
xref: EC:3.4.22.27
xref: MetaCyc:3.4.22.27-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0004219
name: pyroglutamyl-peptidase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide." [EC:3.4.19.3]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "5-oxoprolyl-peptidase activity" EXACT [EC:3.4.19.3]
synonym: "L-pyroglutamyl peptide hydrolase activity" EXACT [EC:3.4.19.3]
synonym: "L-pyrrolidonecarboxylate peptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyrase activity" EXACT [EC:3.4.19.3]
synonym: "PYRase activity" EXACT [EC:3.4.19.3]
synonym: "pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyroglutamidase activity" EXACT [EC:3.4.19.3]
synonym: "pyroglutamyl aminopeptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyrrolidone carboxyl peptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyrrolidone-carboxyl peptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyrrolidone-carboxylate peptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyrrolidonecarboxylyl peptidase activity" EXACT [EC:3.4.19.3]
synonym: "pyrrolidonyl peptidase activity" EXACT [EC:3.4.19.3]
xref: EC:3.4.19.3
xref: MetaCyc:PYROGLUTAMYL-PEPTIDASE-I-RXN
is_obsolete: true
replaced_by: GO:0008234
replaced_by: GO:0016920

[Term]
id: GO:0004221
name: ubiquitin thiolesterase activity
namespace: molecular_function
alt_id: GO:0008577
def: "Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15]
comment: Note that this term is distinguished from its parent in that it specifically refers to hydrolysis of thiolester bonds.
subset: gosubset_prok
synonym: "ubiquitin C-terminal hydrolase activity" RELATED []
synonym: "ubiquitin carboxy-terminal esterase activity" EXACT [EC:3.1.2.15]
synonym: "ubiquitin carboxy-terminal hydrolase activity" RELATED [EC:3.1.2.15]
synonym: "ubiquitin thioesterase activity" EXACT [EC:3.1.2.15]
synonym: "ubiquitin-C-terminal-thioester hydrolase activity" EXACT [EC:3.1.2.15]
synonym: "ubiquitinyl hydrolase 1 activity" NARROW []
xref: EC:3.1.2.15
xref: MetaCyc:UBIQUITIN-THIOLESTERASE-RXN
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0004222
name: metalloendopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE]
subset: gosubset_prok
synonym: "metalloendoprotease activity" EXACT [GOC:mah]
synonym: "metalloendoproteinase activity" EXACT [GOC:mah]
xref: EC:3.4.24
xref: Reactome:1791 "metalloendopeptidase activity"
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0008237 ! metallopeptidase activity

[Term]
id: GO:0004226
name: Gly-X carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa." [EC:3.4.17.4]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "carboxypeptidase a" RELATED [EC:3.4.17.4]
synonym: "carboxypeptidase S activity" EXACT [EC:3.4.17.4]
synonym: "Gly-Xaa carboxypeptidase activity" EXACT [EC:3.4.17.4]
synonym: "glycine carboxypeptidase activity" EXACT [EC:3.4.17.4]
synonym: "peptidase alpha" RELATED [EC:3.4.17.4]
synonym: "yeast carboxypeptidase activity" EXACT [EC:3.4.17.4]
xref: EC:3.4.17.4
xref: MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0004228
name: gelatinase A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond." [EC:3.4.24.24]
comment: This term was made obsolete because it represents a gene product.
synonym: "3/4 collagenase activity" EXACT [EC:3.4.24.24]
synonym: "72 kDa gelatinase type A" RELATED [EC:3.4.24.24]
synonym: "72-kDa gelatinase activity" NARROW [EC:3.4.24.24]
synonym: "collagenase IV" RELATED [EC:3.4.24.24]
synonym: "collagenase type IV" RELATED [EC:3.4.24.24]
synonym: "matrix metalloproteinase 2 activity" EXACT [EC:3.4.24.24]
synonym: "matrix metalloproteinase 5" RELATED [EC:3.4.24.24]
synonym: "MMP 2" RELATED [EC:3.4.24.24]
synonym: "MMP-2" EXACT []
synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.24]
synonym: "type IV collagenase activity" EXACT [EC:3.4.24.24]
synonym: "type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.24]
xref: EC:3.4.24.24
xref: MetaCyc:3.4.24.24-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004229
name: gelatinase B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V." [EC:3.4.24.35]
comment: This term was made obsolete because it represents a gene product.
synonym: "92-kDa gelatinase activity" NARROW [EC:3.4.24.35]
synonym: "92-kDa type IV collagenase activity" NARROW [EC:3.4.24.35]
synonym: "95 kDa type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.35]
synonym: "collagenase IV" RELATED [EC:3.4.24.35]
synonym: "collagenase type IV" RELATED [EC:3.4.24.35]
synonym: "gelatinase MMP 9" RELATED [EC:3.4.24.35]
synonym: "macrophage gelatinase activity" NARROW [EC:3.4.24.35]
synonym: "matrix metalloproteinase 9 activity" EXACT [EC:3.4.24.35]
synonym: "MMP 9" RELATED [EC:3.4.24.35]
synonym: "MMP-9" EXACT []
synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.35]
synonym: "type V collagenase activity" EXACT [EC:3.4.24.35]
xref: EC:3.4.24.35
xref: MetaCyc:3.4.24.35-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004230
name: glutamyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide." [EC:3.4.11.7]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "aminopeptidase A" RELATED [EC:3.4.11.7]
synonym: "angiotensinase A" RELATED [EC:3.4.11.7]
synonym: "angiotensinase A2" RELATED [EC:3.4.11.7]
synonym: "antigen BP-1/6C3 of mouse B lymphocytes" RELATED [EC:3.4.11.7]
synonym: "aspartate aminopeptidase activity" EXACT [EC:3.4.11.7]
synonym: "Ca2+-activated glutamate aminopeptidase activity" EXACT [EC:3.4.11.7]
synonym: "glutamyl peptidase activity" EXACT [EC:3.4.11.7]
synonym: "L-aspartate aminopeptidase activity" EXACT [EC:3.4.11.7]
synonym: "membrane aminopeptidase II" RELATED [EC:3.4.11.7]
xref: EC:3.4.11.7
xref: MetaCyc:3.4.11.7-RXN
is_obsolete: true
replaced_by: GO:0004177
replaced_by: GO:0008235

[Term]
id: GO:0004231
name: insulysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins." [EC:3.4.24.56]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "IDE" RELATED [EC:3.4.24.56]
synonym: "insulin protease activity" EXACT [EC:3.4.24.56]
synonym: "insulin proteinase activity" EXACT [EC:3.4.24.56]
synonym: "insulin-degrading enzyme activity" EXACT [EC:3.4.24.56]
synonym: "insulin-degrading neutral proteinase activity" EXACT [EC:3.4.24.56]
synonym: "insulin-glucagon protease activity" EXACT [EC:3.4.24.56]
synonym: "insulin-specific protease activity" EXACT [EC:3.4.24.56]
synonym: "insulinase activity" EXACT [EC:3.4.24.56]
synonym: "metalloinsulinase activity" EXACT [EC:3.4.24.56]
xref: EC:3.4.24.56
xref: MetaCyc:3.4.24.56-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004232
name: interstitial collagenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue." [EC:3.4.24.7]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 1" EXACT []
synonym: "MMP-1" EXACT []
synonym: "vertebrate collagenase activity" EXACT [EC:3.4.24.7]
xref: EC:3.4.24.7
xref: MetaCyc:3.4.24.7-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004234
name: macrophage elastase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin." [EC:3.4.24.65]
comment: This term was made obsolete because it represents a gene product.
synonym: "human macrophage metalloelastase (HME)" EXACT [EC:3.4.24.65]
synonym: "matrix metalloproteinase 12 activity" EXACT [EC:3.4.24.65]
synonym: "metalloelastase activity" EXACT [EC:3.4.24.65]
synonym: "metalloesterase activity" EXACT []
synonym: "MMP-12" EXACT []
xref: EC:3.4.24.65
xref: MetaCyc:3.4.24.65-RXN
is_obsolete: true
replaced_by: GO:0004175
replaced_by: GO:0004222

[Term]
id: GO:0004235
name: matrilysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)." [EC:3.4.24.23]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrin activity" EXACT [EC:3.4.24.23]
synonym: "matrix metalloproteinase 7 activity" EXACT [EC:3.4.24.23]
synonym: "matrix metalloproteinase pump 1" RELATED [EC:3.4.24.23]
synonym: "metalloproteinase pump-1" RELATED [EC:3.4.24.23]
synonym: "MMP" RELATED [EC:3.4.24.23]
synonym: "MMP 7" RELATED [EC:3.4.24.23]
synonym: "MMP-7" EXACT []
synonym: "PUMP" RELATED [EC:3.4.24.23]
synonym: "PUMP-1 activity" NARROW [EC:3.4.24.23]
synonym: "PUMP-1 proteinase activity" EXACT [EC:3.4.24.23]
synonym: "putative (or punctuated) metalloproteinase-1 activity" NARROW [EC:3.4.24.23]
synonym: "putative metalloproteinase activity" EXACT [EC:3.4.24.23]
synonym: "uterine metalloendopeptidase activity" NARROW [EC:3.4.24.23]
xref: EC:3.4.24.23
xref: MetaCyc:3.4.24.23-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004237
name: membrane dipeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides." [EC:3.4.13.19]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "aminodipeptidase activity" EXACT [EC:3.4.13.19]
synonym: "dehydropeptidase I (DPH I)" RELATED [EC:3.4.13.19]
synonym: "dehydropeptidase I activity" EXACT [EC:3.4.13.19]
synonym: "dipeptide hydrolase" BROAD [EC:3.4.13.19]
synonym: "dipeptidyl hydrolase activity" EXACT [EC:3.4.13.19]
synonym: "DPH I activity" NARROW [EC:3.4.13.19]
synonym: "glycosyl-phosphatidylinositol-anchored renal dipeptidase activity" EXACT [EC:3.4.13.19]
synonym: "MDP" RELATED [EC:3.4.13.19]
synonym: "microsomal dipeptidase activity" NARROW [EC:3.4.13.19]
synonym: "nonspecific dipeptidase activity" EXACT [EC:3.4.13.19]
synonym: "renal dipeptidase activity" NARROW [EC:3.4.13.19]
xref: EC:3.4.13.19
xref: MetaCyc:3.4.13.19-RXN
is_obsolete: true
replaced_by: GO:0008235
replaced_by: GO:0016805

[Term]
id: GO:0004238
name: meprin A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18]
comment: This term was made obsolete because it represents a gene product.
synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.18]
synonym: "meprin" RELATED [EC:3.4.24.18]
synonym: "meprin-a" RELATED [EC:3.4.24.18]
synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase activity" EXACT [EC:3.4.24.18]
synonym: "PABA-peptide hydrolase activity" EXACT [EC:3.4.24.18]
synonym: "PPH" RELATED [EC:3.4.24.18]
xref: EC:3.4.24.18
xref: MetaCyc:3.4.24.18-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004239
name: methionyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides." [EC:3.4.11.18]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "L-methionine aminopeptidase activity" EXACT [EC:3.4.11.18]
synonym: "MAP" RELATED [EC:3.4.11.18]
synonym: "methionine aminopeptidase activity" EXACT [EC:3.4.11.18]
synonym: "peptidase M activity" EXACT [EC:3.4.11.18]
xref: EC:3.4.11.18
xref: MetaCyc:3.4.11.18-RXN
is_obsolete: true
replaced_by: GO:0004177
replaced_by: GO:0008235
consider: GO:0070084

[Term]
id: GO:0004240
name: mitochondrial processing peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2." [EC:3.4.24.64]
comment: This term was made obsolete because it represents a gene product.
synonym: "alpha-mitochondrial processing peptidase" NARROW []
synonym: "beta-mitochondrial processing peptidase" NARROW []
synonym: "matrix peptidase" RELATED [EC:3.4.24.64]
synonym: "matrix processing peptidase" RELATED [EC:3.4.24.64]
synonym: "matrix processing proteinase" RELATED [EC:3.4.24.64]
synonym: "mitochondrial protein precursor-processing proteinase activity" EXACT [EC:3.4.24.64]
synonym: "MPP" EXACT []
synonym: "processing enhancing peptidase (for one of two subunits)" RELATED [EC:3.4.24.64]
synonym: "processing enhancing peptidase activity" NARROW [EC:3.4.24.64]
xref: EC:3.4.24.64
xref: MetaCyc:3.4.24.64-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004241
name: alpha-mitochondrial processing peptidase
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "alpha-MPP" EXACT []
is_obsolete: true
consider: GO:0004222
consider: GO:0005739

[Term]
id: GO:0004242
name: beta-mitochondrial processing peptidase
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "beta-MPP" EXACT []
is_obsolete: true
consider: GO:0004222
consider: GO:0005739

[Term]
id: GO:0004243
name: mitochondrial intermediate peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion." [EC:3.4.24.59]
comment: This term was made obsolete because it represents a gene product.
synonym: "MIP" BROAD []
synonym: "mitochondrial intermediate precursor-processing proteinase activity" EXACT [EC:3.4.24.59]
xref: EC:3.4.24.59
xref: MetaCyc:3.4.24.59-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004244
name: mitochondrial inner membrane peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space." [PMID:12191769]
comment: This term was made obsolete because it represents a gene product.
synonym: "IMP" BROAD []
xref: EC:3.4.99.-
is_obsolete: true
replaced_by: GO:0004175

[Term]
id: GO:0004245
name: neprilysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides." [EC:3.4.24.11]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11]
synonym: "CALLA" RELATED [EC:3.4.24.11]
synonym: "CALLA (common acute lymphoblastic leukemia-associated) antigens" RELATED [EC:3.4.24.11]
synonym: "CALLA antigen" RELATED [EC:3.4.24.11]
synonym: "CALLA glycoprotein" RELATED [EC:3.4.24.11]
synonym: "CALLA glycoproteins" RELATED [EC:3.4.24.11]
synonym: "CD10" RELATED [EC:3.4.24.11]
synonym: "common acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11]
synonym: "common acute lymphoblastic leukemia-associated antigens" RELATED [EC:3.4.24.11]
synonym: "endopeptidase 24.11" RELATED [EC:3.4.24.11]
synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.11]
synonym: "enkephalinase activity" EXACT [EC:3.4.24.11]
synonym: "kidney-brush-border neutral endopeptidase" NARROW [EC:3.4.24.11]
synonym: "kidney-brush-border neutral peptidase" NARROW [EC:3.4.24.11]
synonym: "kidney-brush-border neutral proteinase activity" NARROW [EC:3.4.24.11]
synonym: "membrane metalloendopeptidase activity" NARROW [EC:3.4.24.11]
synonym: "neutral endopeptidase 24.11" RELATED [EC:3.4.24.11]
synonym: "neutral endopeptidase activity" EXACT [EC:3.4.24.11]
synonym: "neutral metallendopeptidase activity" EXACT [EC:3.4.24.11]
xref: EC:3.4.24.11
xref: MetaCyc:3.4.24.11-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004246
name: peptidyl-dipeptidase A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II." [EC:3.4.15.1]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "ACE activity" BROAD []
synonym: "angiotensin converting enzyme" RELATED [EC:3.4.15.1]
synonym: "angiotensin I-converting enzyme activity" EXACT [EC:3.4.15.1]
synonym: "carboxycathepsin activity" EXACT [EC:3.4.15.1]
synonym: "DCP" RELATED [EC:3.4.15.1]
synonym: "dipeptide hydrolase" BROAD [EC:3.4.15.1]
synonym: "dipeptidyl carboxypeptidase I activity" EXACT [EC:3.4.15.1]
synonym: "endothelial cell peptidyl dipeptidase activity" EXACT [EC:3.4.15.1]
synonym: "kininase II activity" EXACT [EC:3.4.15.1]
synonym: "PDH" RELATED [EC:3.4.15.1]
synonym: "peptidase P activity" EXACT [EC:3.4.15.1]
synonym: "peptidyl dipeptidase A" RELATED [EC:3.4.15.1]
synonym: "peptidyl dipeptidase I activity" EXACT [EC:3.4.15.1]
synonym: "peptidyl dipeptidase-4" RELATED [EC:3.4.15.1]
synonym: "peptidyl dipeptide hydrolase activity" EXACT [EC:3.4.15.1]
synonym: "peptidyl-dipeptide hydrolase activity" EXACT [EC:3.4.15.1]
synonym: "peptidyldipeptide hydrolase activity" EXACT [EC:3.4.15.1]
xref: EC:3.4.15.1
xref: MetaCyc:3.4.15.1-RXN
is_obsolete: true
replaced_by: GO:0008237
replaced_by: GO:0008241

[Term]
id: GO:0004247
name: saccharolysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds." [EC:3.4.24.37]
comment: This term was made obsolete because it represents a gene product.
synonym: "oligopeptidase yscD activity" NARROW [EC:3.4.24.37]
synonym: "proteinase yscD activity" NARROW [EC:3.4.24.37]
synonym: "saccharomyces cerevisiae proteinase yscD" RELATED [EC:3.4.24.37]
synonym: "yeast cysteine proteinase D activity" NARROW [EC:3.4.24.37]
xref: EC:3.4.24.37
xref: MetaCyc:3.4.24.37-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004248
name: stromelysin 1 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues." [EC:3.4.24.17]
comment: This term was made obsolete because it represents a gene product.
synonym: "collagen-activating protein" RELATED [EC:3.4.24.17]
synonym: "collagenase activating protein" RELATED [EC:3.4.24.17]
synonym: "matrix metalloproteinase 3 activity" EXACT [EC:3.4.24.17]
synonym: "MMP-3" EXACT []
synonym: "neutral proteoglycanase activity" EXACT [EC:3.4.24.17]
synonym: "procollagenase activator" RELATED [EC:3.4.24.17]
synonym: "proteoglycanase activity" EXACT [EC:3.4.24.17]
synonym: "stromelysin" RELATED [EC:3.4.24.17]
synonym: "transin activity" EXACT [EC:3.4.24.17]
xref: EC:3.4.24.17
xref: MetaCyc:3.4.24.17-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004249
name: stromelysin 3 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 11" EXACT []
synonym: "MMP-11" EXACT []
xref: EC:3.4.24.-
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0004250
name: aminopeptidase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates." [EC:3.4.11.22]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "aminopeptidase III activity" EXACT [EC:3.4.11.22]
synonym: "aminopeptidase yscI activity" NARROW [EC:3.4.11.22]
synonym: "leucine aminopeptidase IV activity" EXACT [EC:3.4.11.22]
synonym: "vacuolar aminopeptidase I activity" NARROW [EC:3.4.11.22]
synonym: "yeast aminopeptidase I" RELATED [EC:3.4.11.22]
xref: EC:3.4.11.22
xref: MetaCyc:3.4.11.22-RXN
is_obsolete: true
replaced_by: GO:0004177
replaced_by: GO:0008235

[Term]
id: GO:0004251
name: X-Pro dipeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro." [EC:3.4.13.9]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "gamma-peptidase activity" EXACT [EC:3.4.13.9]
synonym: "imidodipeptidase activity" EXACT [EC:3.4.13.9]
synonym: "peptidase D" RELATED [EC:3.4.13.9]
synonym: "prolidase activity" EXACT [EC:3.4.13.9]
synonym: "proline dipeptidase activity" EXACT [EC:3.4.13.9]
synonym: "Xaa-Pro dipeptidase activity" EXACT []
xref: EC:3.4.13.9
xref: MetaCyc:3.4.13.9-RXN
is_obsolete: true
replaced_by: GO:0008235
replaced_by: GO:0016805

[Term]
id: GO:0004252
name: serine-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, ISBN:0716720094]
subset: gosubset_prok
synonym: "blood coagulation factor activity" RELATED []
xref: EC:3.4.21
xref: Reactome:1683 "serine-type endopeptidase activity"
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0008236 ! serine-type peptidase activity

[Term]
id: GO:0004253
name: gamma-renin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide." [EC:3.4.21.54]
comment: This term was made obsolete because it represents a gene product.
xref: EC:3.4.21.54
xref: MetaCyc:3.4.21.54-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004254
name: acylaminoacyl-peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide." [EC:3.4.19.1]
subset: gosubset_prok
synonym: "acylamino-acid-releasing enzyme activity" EXACT [EC:3.4.19.1]
synonym: "alpha-N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1]
synonym: "N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1]
synonym: "N-formylmethionine (fMet) aminopeptidase activity" EXACT [EC:3.4.19.1]
xref: EC:3.4.19.1
xref: MetaCyc:ACYLAMINOACYL-PEPTIDASE-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004258
name: vacuolar carboxypeptidase Y
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5]
comment: This term was made obsolete because it contains both component and function information.
is_obsolete: true
consider: GO:0004185
consider: GO:0005773

[Term]
id: GO:0004261
name: cathepsin G activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C." [EC:3.4.21.20]
comment: This term was made obsolete because it represents a gene product.
synonym: "chymotrypsin-like proteinase activity" EXACT [EC:3.4.21.20]
synonym: "neutral proteinase activity" EXACT [EC:3.4.21.20]
xref: EC:3.4.21.20
xref: MetaCyc:3.4.21.20-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004262
name: cerevisin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides." [EC:3.4.21.48]
comment: This term was made obsolete because it represents a gene product.
synonym: "baker's yeast proteinase B" RELATED [EC:3.4.21.48]
synonym: "brewer's yeast proteinase" NARROW [EC:3.4.21.48]
synonym: "peptidase beta" RELATED [EC:3.4.21.48]
synonym: "proteinase yscB activity" NARROW [EC:3.4.21.48]
synonym: "yeast proteinase B activity" NARROW [EC:3.4.21.48]
xref: EC:3.4.21.48
xref: MetaCyc:3.4.21.48-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004263
name: chymotrypsin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa." [EC:3.4.21.1, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "alpha-chymar" RELATED [EC:3.4.21.1]
synonym: "alpha-chymar ophth" RELATED [EC:3.4.21.1]
synonym: "alpha-chymotrypsin A" RELATED [EC:3.4.21.1]
synonym: "alpha-chymotrypsin activity" NARROW [EC:3.4.21.1]
synonym: "avazyme" RELATED [EC:3.4.21.1]
synonym: "chymar" RELATED [EC:3.4.21.1]
synonym: "chymotest" RELATED [EC:3.4.21.1]
synonym: "chymotrypsin A activity" NARROW [EC:3.4.21.1]
synonym: "chymotrypsin B activity" NARROW [EC:3.4.21.1]
synonym: "chymotrypsins A and B" RELATED [EC:3.4.21.1]
synonym: "enzeon" RELATED [EC:3.4.21.1]
synonym: "quimar" RELATED [EC:3.4.21.1]
synonym: "quimotrase activity" EXACT [EC:3.4.21.1]
xref: EC:3.4.21.1
xref: MetaCyc:3.4.21.1-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004274
name: dipeptidyl-peptidase IV activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline." [EC:3.4.14.5]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "amino acyl-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.5]
synonym: "dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5]
synonym: "dipeptidyl peptidase IV" RELATED [EC:3.4.14.5]
synonym: "dipeptidyl-aminopeptidase IV" RELATED [EC:3.4.14.5]
synonym: "dipeptidyl-peptide hydrolase activity" EXACT [EC:3.4.14.5]
synonym: "DPP IV activity" EXACT [EC:3.4.14.5]
synonym: "DPP IV/CD26" RELATED [EC:3.4.14.5]
synonym: "Gly-Pro naphthylamidase activity" EXACT [EC:3.4.14.5]
synonym: "glycoprotein GP110" RELATED [EC:3.4.14.5]
synonym: "glycylproline aminopeptidase activity" EXACT [EC:3.4.14.5]
synonym: "glycylprolyl aminopeptidase activity" EXACT [EC:3.4.14.5]
synonym: "glycylprolyl dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5]
synonym: "leukocyte antigen CD26" RELATED [EC:3.4.14.5]
synonym: "lymphocyte antigen CD26" RELATED [EC:3.4.14.5]
synonym: "pep X" RELATED [EC:3.4.14.5]
synonym: "post-proline dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5]
synonym: "postproline dipeptidyl aminopeptidase IV" RELATED [EC:3.4.14.5]
synonym: "T cell triggering molecule Tp103" RELATED [EC:3.4.14.5]
synonym: "X-PDAP" RELATED [EC:3.4.14.5]
synonym: "Xaa-Pro-dipeptidyl-aminopeptidase activity" EXACT [EC:3.4.14.5]
synonym: "Xaa-Pro-dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5]
xref: EC:3.4.14.5
xref: MetaCyc:3.4.14.5-RXN
is_obsolete: true
replaced_by: GO:0008236
replaced_by: GO:0008239

[Term]
id: GO:0004275
name: enteropeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen." [EC:3.4.21.9]
comment: This term was made obsolete because it represents a gene product.
synonym: "enterokinase activity" RELATED [EC:3.4.21.9]
xref: EC:3.4.21.9
xref: MetaCyc:3.4.21.9-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004276
name: furin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors." [EC:3.4.21.75]
comment: This term was made obsolete because it represents a gene product.
synonym: "dibasic processing enzyme activity" EXACT [EC:3.4.21.75]
synonym: "PACE" RELATED [EC:3.4.21.75]
synonym: "paired basic amino acid cleaving enzyme" RELATED [EC:3.4.21.75]
synonym: "paired basic amino acid converting enzyme" RELATED [EC:3.4.21.75]
synonym: "paired basic amino acid residue cleaving enzyme activity" EXACT [EC:3.4.21.75]
synonym: "prohormone convertase activity" NARROW [EC:3.4.21.75]
synonym: "serine proteinase PACE" RELATED [EC:3.4.21.75]
synonym: "SPC3" RELATED [EC:3.4.21.75]
xref: EC:3.4.21.75
xref: MetaCyc:3.4.21.75-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004277
name: granzyme A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates." [EC:3.4.21.78]
comment: This term was made obsolete because it represents a gene product.
synonym: "CTLA3" RELATED [EC:3.4.21.78]
synonym: "cytotoxic T lymphocyte serine protease" NARROW [EC:3.4.21.78]
synonym: "cytotoxic T-lymphocyte proteinase 1 activity" NARROW [EC:3.4.21.78]
synonym: "HuTPS" RELATED [EC:3.4.21.78]
synonym: "T-cell associated protease 1" RELATED [EC:3.4.21.78]
synonym: "T-cell derived serine proteinase" NARROW [EC:3.4.21.78]
synonym: "TSP-1" RELATED [EC:3.4.21.78]
xref: EC:3.4.21.78
xref: MetaCyc:3.4.21.78-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004278
name: granzyme B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa." [EC:3.4.21.79]
comment: This term was made obsolete because it represents a gene product.
synonym: "CCP1 proteinase" NARROW [EC:3.4.21.79]
synonym: "CCPII" RELATED [EC:3.4.21.79]
synonym: "CTLA1" RELATED [EC:3.4.21.79]
synonym: "cytotoxic cell proteinase-1" RELATED [EC:3.4.21.79]
synonym: "cytotoxic t-lymphocyte proteinase 2 activity" NARROW [EC:3.4.21.79]
synonym: "granzyme G" RELATED [EC:3.4.21.79]
synonym: "granzyme H" RELATED [EC:3.4.21.79]
xref: EC:3.4.21.79
xref: MetaCyc:3.4.21.79-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004281
name: pancreatic elastase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin." [EC:3.4.21.71]
comment: This term was made obsolete because it represents a gene product.
synonym: "pancreatic elastase 2" RELATED [EC:3.4.21.71]
xref: EC:3.4.21.71
xref: MetaCyc:3.4.21.71-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004283
name: plasmin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products." [EC:3.4.21.7]
comment: This term was made obsolete because it represents a gene product.
synonym: "actase activity" EXACT [EC:3.4.21.7]
synonym: "fibrinase activity" EXACT [EC:3.4.21.7]
synonym: "fibrinolysin activity" EXACT [EC:3.4.21.7]
synonym: "serum tryptase activity" EXACT [EC:3.4.21.7]
synonym: "thrombolysin" RELATED [EC:3.4.21.7]
xref: EC:3.4.21.7
xref: MetaCyc:3.4.21.7-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004284
name: acrosin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa." [EC:3.4.21.10]
comment: This term was made obsolete because it represents a gene product.
synonym: "acrosin amidase activity" EXACT [EC:3.4.21.10]
synonym: "acrosomal protease activity" EXACT [EC:3.4.21.10]
synonym: "acrosomal proteinase activity" EXACT [EC:3.4.21.10]
synonym: "acrozonase activity" EXACT [EC:3.4.21.10]
synonym: "alpha-acrosin" RELATED [EC:3.4.21.10]
synonym: "beta-acrosin" RELATED [EC:3.4.21.10]
synonym: "psi-acrosin" RELATED [EC:3.4.21.10]
xref: EC:3.4.21.10
xref: MetaCyc:3.4.21.10-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004285
name: proprotein convertase 1 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.93]
comment: This term was made obsolete because it represents a gene product.
synonym: "NEC 1 activity" NARROW [EC:3.4.21.93]
synonym: "neuroendocrine convertase 1 activity" NARROW [EC:3.4.21.93]
synonym: "PC1 activity" NARROW [EC:3.4.21.93]
synonym: "prohormone convertase 3" RELATED [EC:3.4.21.93]
synonym: "prohormone convertase I activity" NARROW [EC:3.4.21.93]
xref: EC:3.4.21.93
xref: MetaCyc:3.4.21.93-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004286
name: proprotein convertase 2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.94]
comment: This term was made obsolete because it represents a gene product.
synonym: "NEC 2 activity" NARROW [EC:3.4.21.94]
synonym: "neuroendocrine convertase 2 activity" NARROW [EC:3.4.21.94]
synonym: "PC2 activity" NARROW [EC:3.4.21.94]
synonym: "prohormone convertase II activity" NARROW [EC:3.4.21.94]
xref: EC:3.4.21.94
xref: MetaCyc:3.4.21.94-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004287
name: prolyl oligopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides." [EC:3.4.21.26]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "endoprolylpeptidase activity" EXACT [EC:3.4.21.26]
synonym: "post-proline cleaving enzyme activity" EXACT [EC:3.4.21.26]
synonym: "post-proline endopeptidase activity" EXACT [EC:3.4.21.26]
synonym: "proline endopeptidase activity" EXACT [EC:3.4.21.26]
synonym: "proline-specific endopeptidase activity" EXACT [EC:3.4.21.26]
synonym: "prolyl endopeptidase activity" EXACT [EC:3.4.21.26]
xref: EC:3.4.21.26
xref: MetaCyc:3.4.21.26-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004289
name: subtilase activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
xref: EC:3.4.21.-
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004290
name: kexin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors." [EC:3.4.21.61]
comment: This term was made obsolete because it represents a gene product.
synonym: "andrenorphin-Gly-generating enzyme" RELATED [EC:3.4.21.61]
synonym: "endoproteinase Kex2p" RELATED [EC:3.4.21.61]
synonym: "gene KEX2 dibasic proteinase" NARROW [EC:3.4.21.61]
synonym: "Kex 2p proteinase" NARROW [EC:3.4.21.61]
synonym: "Kex2 endopeptidase" NARROW [EC:3.4.21.61]
synonym: "Kex2 endoprotease" NARROW [EC:3.4.21.61]
synonym: "Kex2 endoproteinase" NARROW [EC:3.4.21.61]
synonym: "Kex2 protease" NARROW [EC:3.4.21.61]
synonym: "Kex2 proteinase" NARROW [EC:3.4.21.61]
synonym: "Kex2-like endoproteinase" NARROW [EC:3.4.21.61]
synonym: "Kex2-like precursor protein processing endoprotease" NARROW [EC:3.4.21.61]
synonym: "paired-basic endopeptidase activity" EXACT [EC:3.4.21.61]
synonym: "prohormone-processing endoprotease activity" RELATED [EC:3.4.21.61]
synonym: "prohormone-processing KEX2 proteinase" NARROW [EC:3.4.21.61]
synonym: "prohormone-processing proteinase activity" EXACT [EC:3.4.21.61]
synonym: "protease KEX2" RELATED [EC:3.4.21.61]
synonym: "proteinase Kex2p" RELATED [EC:3.4.21.61]
synonym: "proteinase yscF activity" NARROW [EC:3.4.21.61]
synonym: "yeast cysteine proteinase F" RELATED [EC:3.4.21.61]
synonym: "yeast KEX2 protease activity" NARROW [EC:3.4.21.61]
xref: EC:3.4.21.61
xref: MetaCyc:3.4.21.61-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004291
name: subtilisin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides." [EC:3.4.21.62]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "alcalase 0.6L" RELATED [EC:3.4.21.62]
synonym: "alcalase 2.5L" RELATED [EC:3.4.21.62]
synonym: "alcalase activity" EXACT [EC:3.4.21.62]
synonym: "ALK-enzyme" RELATED [EC:3.4.21.62]
synonym: "bacillopeptidase A" RELATED [EC:3.4.21.62]
synonym: "bacillopeptidase B" RELATED [EC:3.4.21.62]
synonym: "bacillus subtilis alkaline proteinase activity" EXACT [EC:3.4.21.62]
synonym: "bacillus subtilis alkaline proteinase bioprase activity" EXACT [EC:3.4.21.62]
synonym: "bioprase AL 15" RELATED [EC:3.4.21.62]
synonym: "bioprase APL 30" RELATED [EC:3.4.21.62]
synonym: "colistinase activity" EXACT [EC:3.4.21.62]
synonym: "esperase activity" EXACT [EC:3.4.21.62]
synonym: "genenase I" RELATED [EC:3.4.21.62]
synonym: "kazusase activity" EXACT [EC:3.4.21.62]
synonym: "maxatase activity" EXACT [EC:3.4.21.62]
synonym: "opticlean" RELATED [EC:3.4.21.62]
synonym: "orientase 10B" RELATED [EC:3.4.21.62]
synonym: "protease S" RELATED [EC:3.4.21.62]
synonym: "protease VIII" RELATED [EC:3.4.21.62]
synonym: "protease XXVII" RELATED [EC:3.4.21.62]
synonym: "protin A 3L" RELATED [EC:3.4.21.62]
synonym: "savinase 16.0L" RELATED [EC:3.4.21.62]
synonym: "savinase 32.0 L EX" RELATED [EC:3.4.21.62]
synonym: "savinase 4.0T" RELATED [EC:3.4.21.62]
synonym: "savinase 8.0L" RELATED [EC:3.4.21.62]
synonym: "savinase activity" EXACT [EC:3.4.21.62]
synonym: "SP 266" RELATED [EC:3.4.21.62]
synonym: "subtilisin BL" RELATED [EC:3.4.21.62]
synonym: "subtilisin DY" RELATED [EC:3.4.21.62]
synonym: "subtilisin E" RELATED [EC:3.4.21.62]
synonym: "subtilisin GX" RELATED [EC:3.4.21.62]
synonym: "subtilisin J" RELATED [EC:3.4.21.62]
synonym: "subtilisin S41" RELATED [EC:3.4.21.62]
synonym: "subtilisin sendai" RELATED [EC:3.4.21.62]
synonym: "subtilopeptidase activity" EXACT [EC:3.4.21.62]
synonym: "superase activity" EXACT [EC:3.4.21.62]
synonym: "thermoase" BROAD [EC:3.4.21.62]
synonym: "thermoase PC 10" RELATED [EC:3.4.21.62]
xref: EC:3.4.21.62
xref: MetaCyc:3.4.21.62-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004293
name: tissue kallikrein activity
namespace: molecular_function
alt_id: GO:0004279
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds." [EC:3.4.21.35]
comment: This term was made obsolete because it represents a gene product.
synonym: "bradykininogenase" BROAD [EC:3.4.21.35]
synonym: "callicrein" RELATED [EC:3.4.21.35]
synonym: "depot-padutin" RELATED [EC:3.4.21.35]
synonym: "dilminal D" RELATED [EC:3.4.21.35]
synonym: "glandular kallikrein activity" RELATED [EC:3.4.21.35]
synonym: "glumorin" RELATED [EC:3.4.21.35]
synonym: "kallidinogenase" BROAD [EC:3.4.21.35]
synonym: "kallikrein" RELATED [EC:3.4.21.35]
synonym: "kidney kallikrein" RELATED [EC:3.4.21.35]
synonym: "kininogenase" BROAD [EC:3.4.21.35]
synonym: "kininogenin activity" RELATED [EC:3.4.21.35]
synonym: "onokrein P" RELATED [EC:3.4.21.35]
synonym: "padreatin" RELATED [EC:3.4.21.35]
synonym: "padutin" RELATED [EC:3.4.21.35]
synonym: "pancreatic kallikrein" RELATED [EC:3.4.21.35]
synonym: "salivary kallikrein" RELATED [EC:3.4.21.35]
synonym: "submandibular kallikrein" RELATED [EC:3.4.21.35]
synonym: "submaxillary kallikrein" RELATED [EC:3.4.21.35]
synonym: "urinary kallikrein" RELATED [EC:3.4.21.35]
synonym: "urokallikrein" RELATED [EC:3.4.21.35]
xref: EC:3.4.21.35
xref: MetaCyc:3.4.21.35-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004294
name: tripeptidyl-peptidase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH." [EC:3.4.14.10]
comment: This term was made obsolete because it represents a gene product.
synonym: "TPP" RELATED [EC:3.4.14.10]
synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.10]
synonym: "tripeptidyl aminopeptidase II" RELATED [EC:3.4.14.10]
synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.10]
synonym: "tripeptidyl peptidase II" RELATED [EC:3.4.14.10]
xref: EC:3.4.14.10
xref: MetaCyc:3.4.14.10-RXN
is_obsolete: true
replaced_by: GO:0008240

[Term]
id: GO:0004295
name: trypsin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa." [EC:3.4.21.4]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "alpha-trypsin activity" NARROW [EC:3.4.21.4]
synonym: "beta-trypsin activity" NARROW [EC:3.4.21.4]
synonym: "cocoonase activity" EXACT [EC:3.4.21.4]
synonym: "parenzyme" RELATED [EC:3.4.21.4]
synonym: "parenzymol" RELATED [EC:3.4.21.4]
synonym: "pseudotrypsin" RELATED [EC:3.4.21.4]
synonym: "sperm receptor hydrolase activity" EXACT [EC:3.4.21.4]
synonym: "tripcellim" RELATED [EC:3.4.21.4]
synonym: "tryptar" RELATED [EC:3.4.21.4]
synonym: "trypure" RELATED [EC:3.4.21.4]
xref: EC:3.4.21.4
xref: MetaCyc:3.4.21.4-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0004298
name: threonine-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE]
subset: gosubset_prok
synonym: "26S protease" NARROW [EC:3.4.25]
synonym: "alkaline protease" RELATED [EC:3.4.25]
synonym: "ingensin" RELATED [EC:3.4.25]
synonym: "large multicatalytic protease" NARROW [EC:3.4.25]
synonym: "lens neutral proteinase" NARROW [EC:3.4.25]
synonym: "MCP" RELATED [EC:3.4.25]
synonym: "multicatalytic endopeptidase complex" RELATED [EC:3.4.25]
synonym: "multicatalytic proteinase" NARROW [EC:3.4.25]
synonym: "multicatalytic proteinase (complex)" NARROW [EC:3.4.25]
synonym: "prosome" RELATED [EC:3.4.25]
synonym: "proteasome endopeptidase complex" NARROW [EC:3.4.25]
synonym: "threonine endopeptidase activity" EXACT []
synonym: "tricorn protease" NARROW [EC:3.4.25]
synonym: "tricorn proteinase" NARROW [EC:3.4.25]
xref: EC:3.4.25
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0070003 ! threonine-type peptidase activity

[Term]
id: GO:0004299
name: proteasome endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity." [EC:3.4.25.1]
comment: This term was made obsolete because it mentions a component term in the text string.
synonym: "multicatalytic endopeptidase" RELATED []
synonym: "proteasome" RELATED []
synonym: "proteasome endopeptidase complex" RELATED []
is_obsolete: true
consider: GO:0004175
consider: GO:0008233

[Term]
id: GO:0004300
name: enoyl-CoA hydratase activity
namespace: molecular_function
alt_id: GO:0016510
def: "Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O." [EC:4.2.1.17]
subset: gosubset_prok
synonym: "(3S)-3-hydroxyacyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.17]
synonym: "2-enoyl-CoA hydratase activity" EXACT [EC:4.2.1.17]
synonym: "2-octenoyl coenzyme A hydrase activity" EXACT [EC:4.2.1.17]
synonym: "acyl coenzyme A hydrase activity" EXACT [EC:4.2.1.17]
synonym: "beta-hydroxyacid dehydrase activity" EXACT [EC:4.2.1.17]
synonym: "beta-hydroxyacyl-CoA dehydrase activity" EXACT [EC:4.2.1.17]
synonym: "crotonyl hydrase activity" EXACT [EC:4.2.1.17]
synonym: "D-3-hydroxyacyl-CoA dehydratase" BROAD [EC:4.2.1.17]
synonym: "ECH" RELATED [EC:4.2.1.17]
synonym: "enol-CoA hydratase activity" EXACT [EC:4.2.1.17]
synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.17]
synonym: "enoyl coenzyme A hydrase (L)" EXACT [EC:4.2.1.17]
synonym: "enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.17]
synonym: "enoyl hydrase activity" EXACT [EC:4.2.1.17]
synonym: "hydratase, enoyl coenzyme A" EXACT [EC:4.2.1.17]
synonym: "short chain enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.17]
synonym: "short-chain enoyl-CoA hydratase activity" EXACT []
synonym: "trans-2-enoyl-CoA hydratase activity" EXACT [EC:4.2.1.17]
synonym: "unsaturated acyl-CoA hydratase activity" EXACT [EC:4.2.1.17]
xref: EC:4.2.1.17
xref: MetaCyc:ENOYL-COA-HYDRAT-RXN
xref: Reactome:10287 "enoyl-CoA hydratase activity"
xref: UM-BBD_enzymeID:e0014
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004301
name: epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: an epoxide + H2O = a glycol." [EC:3.3.2.10]
subset: gosubset_prok
synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.10]
synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.10]
synonym: "cytosolic epoxide hydrolase activity" EXACT [EC:3.3.2.10]
synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.10]
synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.10]
synonym: "sEH" RELATED [EC:3.3.2.10]
synonym: "soluble epoxide hydrolase activity" NARROW [EC:3.3.2.10]
synonym: "trans-stilbene oxide hydrolase activity" EXACT [EC:3.3.2.10]
xref: EC:3.3.2.10
xref: MetaCyc:3.3.2.10-RXN
xref: UM-BBD_enzymeID:e0397
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0004303
name: estradiol 17-beta-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62]
synonym: "17-beta-estradiol dehydrogenase activity" EXACT [EC:1.1.1.62]
synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.62]
synonym: "17-beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.62]
synonym: "17beta,20alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.62]
synonym: "17beta-estradiol dehydrogenase activity" EXACT [EC:1.1.1.62]
synonym: "17beta-HSD" RELATED [EC:1.1.1.62]
synonym: "17beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.62]
synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.62]
synonym: "estradiol 17beta-dehydrogenase activity" EXACT [EC:1.1.1.62]
synonym: "estradiol dehydrogenase activity" EXACT [EC:1.1.1.62]
synonym: "estradiol-17beta:NAD(P)+ 17-oxidoreductase activity" EXACT [EC:1.1.1.62]
synonym: "estrogen 17-oxidoreductase activity" EXACT [EC:1.1.1.62]
xref: EC:1.1.1.62
xref: MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004304
name: estrone sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4]
synonym: "3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity" EXACT [EC:2.8.2.4]
synonym: "3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity" EXACT [EC:2.8.2.4]
synonym: "3'-phosphoadenylylsulfate:oestrone sulfotransferase activity" EXACT [EC:2.8.2.4]
synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.4]
synonym: "estrogen sulphotransferase activity" EXACT [EC:2.8.2.4]
synonym: "estrone sulphotransferase activity" EXACT []
synonym: "oestrogen sulphotransferase activity" EXACT [EC:2.8.2.4]
xref: EC:2.8.2.4
xref: MetaCyc:ESTRONE-SULFOTRANSFERASE-RXN
xref: Reactome:10293 "estrone sulfotransferase activity"
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0004305
name: ethanolamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + ethanolamine = ADP + O-phosphoethanolamine." [EC:2.7.1.82]
synonym: "ATP:ethanolamine O-phosphotransferase activity" EXACT [EC:2.7.1.82]
synonym: "ethanolamine kinase (phosphorylating)" EXACT [EC:2.7.1.82]
synonym: "ethanolamine phosphokinase activity" EXACT [EC:2.7.1.82]
xref: EC:2.7.1.82
xref: MetaCyc:ETHANOLAMINE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004306
name: ethanolamine-phosphate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine." [EC:2.7.7.14]
synonym: "CTP-phosphoethanolamine cytidylyltransferase activity" EXACT [EC:2.7.7.14]
synonym: "CTP:ethanolamine-phosphate cytidylyltransferase activity" EXACT []
synonym: "CTP:phosphoethanolamine cytidylyltransferase activity" EXACT [EC:2.7.7.14]
synonym: "ET" RELATED [EC:2.7.7.14]
synonym: "ethanolamine phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.14]
synonym: "phosphoethanolamine cytidylyltransferase activity" EXACT []
synonym: "phosphorylethanolamine transferase activity" BROAD [EC:2.7.7.14]
xref: EC:2.7.7.14
xref: MetaCyc:2.7.7.14-RXN
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0004307
name: ethanolaminephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine." [EC:2.7.8.1]
synonym: "CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.1]
synonym: "CDPethanolamine diglyceride phosphotransferase activity" EXACT [EC:2.7.8.1]
synonym: "diacylglycerol ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.1]
synonym: "EPT" RELATED [EC:2.7.8.1]
synonym: "phosphorylethanolamine-glyceride transferase activity" EXACT [EC:2.7.8.1]
xref: EC:2.7.8.1
xref: MetaCyc:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN
is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity

[Term]
id: GO:0004308
name: exo-alpha-sialidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates." [EC:3.2.1.18]
subset: gosubset_prok
synonym: "acetylneuraminidase activity" EXACT [EC:3.2.1.18]
synonym: "acetylneuraminyl hydrolase activity" EXACT [EC:3.2.1.18]
synonym: "alpha-neuraminidase activity" EXACT [EC:3.2.1.18]
synonym: "N-acylneuraminate glycohydrolase activity" EXACT [EC:3.2.1.18]
synonym: "neuraminidase activity" EXACT [EC:3.2.1.18]
synonym: "sialidase activity" EXACT [EC:3.2.1.18]
xref: EC:3.2.1.18
xref: MetaCyc:3.2.1.18-RXN
xref: Reactome:10303 "exo-alpha-sialidase activity"
is_a: GO:0016997 ! alpha-sialidase activity

[Term]
id: GO:0004309
name: exopolyphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate." [EC:3.6.1.11]
subset: gosubset_prok
synonym: "acid phosphoanhydride phosphohydrolase activity" EXACT [EC:3.6.1.11]
synonym: "exopolypase activity" EXACT [EC:3.6.1.11]
synonym: "Gra-Pase activity" EXACT [EC:3.6.1.11]
synonym: "metaphosphatase activity" BROAD [EC:3.6.1.11]
synonym: "polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.11]
xref: EC:3.6.1.11
xref: MetaCyc:EXOPOLYPHOSPHATASE-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0004310
name: farnesyl-diphosphate farnesyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate." [EC:2.5.1.21]
subset: gosubset_prok
synonym: "farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase activity" EXACT [EC:2.5.1.21]
synonym: "farnesyltransferase activity" BROAD [EC:2.5.1.21]
synonym: "presqualene synthase activity" EXACT [EC:2.5.1.21]
synonym: "presqualene-diphosphate synthase activity" EXACT [EC:2.5.1.21]
synonym: "squalene synthase activity" EXACT [EC:2.5.1.21]
synonym: "squalene synthetase activity" EXACT [EC:2.5.1.21]
xref: EC:2.5.1.21
xref: MetaCyc:2.5.1.21-RXN
xref: Reactome:10334 "farnesyl-diphosphate farnesyltransferase activity"
is_a: GO:0004311 ! farnesyltranstransferase activity

[Term]
id: GO:0004311
name: farnesyltranstransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate." [EC:2.5.1.29]
subset: gosubset_prok
synonym: "farnesyltransferase activity" BROAD [EC:2.5.1.29]
synonym: "geranylgeranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.29]
synonym: "geranylgeranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.29]
synonym: "geranylgeranyl-diphosphate synthase activity" EXACT [EC:2.5.1.29]
synonym: "geranylgeranyl-PP synthetase activity" EXACT [EC:2.5.1.29]
synonym: "trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT [EC:2.5.1.29]
xref: EC:2.5.1.29
xref: MetaCyc:FARNESYLTRANSTRANSFERASE-RXN
xref: Reactome:10335 "farnesyltranstransferase activity"
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0004312
name: fatty-acid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85]
subset: gosubset_prok
synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)" EXACT [EC:2.3.1.85]
xref: EC:2.3.1.85
xref: MetaCyc:FATTY-ACID-SYNTHASE-RXN
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0004313
name: [acyl-carrier-protein] S-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [EC:2.3.1.38]
synonym: "[acyl-carrier protein] S-acetyltransferase activity" EXACT []
synonym: "ACAT activity" BROAD [EC:2.3.1.38]
synonym: "acetyl coenzyme A-acyl-carrier-protein transacylase activity" EXACT [EC:2.3.1.38]
synonym: "acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38]
synonym: "ACP acetyltransferase activity" EXACT [EC:2.3.1.38]
synonym: "ACP S-acetyltransferase activity" EXACT []
synonym: "ACPacetyltransferase activity" EXACT [EC:2.3.1.38]
synonym: "acyl-carrier-protein acetyltransferase activity" EXACT [EC:2.3.1.38]
synonym: "acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38]
synonym: "acyl-carrier-proteinacetyltransferase activity" EXACT [EC:2.3.1.38]
xref: EC:2.3.1.38
xref: MetaCyc:ACP-S-ACETYLTRANSFER-RXN
xref: Reactome:76142 "[acyl-carrier-protein] S-acetyltransferase activity"
is_a: GO:0004312 ! fatty-acid synthase activity
is_a: GO:0016418 ! S-acetyltransferase activity

[Term]
id: GO:0004314
name: [acyl-carrier-protein] S-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39]
subset: gosubset_prok
synonym: "[acyl-carrier protein] S-malonyltransferase activity" EXACT []
synonym: "ACP S-malonyltransferase activity" EXACT []
synonym: "acyl carrier protein malonyltransferase activity" EXACT [EC:2.3.1.39]
synonym: "acyl carrier proteinmalonyltransferase activity" EXACT [EC:2.3.1.39]
synonym: "acyl-carrier-protein S-malonyltransferase activity" EXACT [EC:2.3.1.39]
synonym: "FabD" RELATED [EC:2.3.1.39]
synonym: "malonyl coenzyme A-acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39]
synonym: "malonyl transacylase activity" BROAD [EC:2.3.1.39]
synonym: "malonyl transferase activity" BROAD [EC:2.3.1.39]
synonym: "malonyl-CoA-acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39]
synonym: "malonyl-CoA:ACP transacylase activity" EXACT [EC:2.3.1.39]
synonym: "malonyl-CoA:AcpM transacylase activity" EXACT [EC:2.3.1.39]
synonym: "malonyl-CoA:acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39]
synonym: "malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity" EXACT [EC:2.3.1.39]
synonym: "MAT" RELATED [EC:2.3.1.39]
synonym: "MCAT activity" EXACT [EC:2.3.1.39]
xref: EC:2.3.1.39
xref: MetaCyc:MALONYL-COA-ACP-TRANSACYL-RXN
xref: Reactome:10341 "[acyl-carrier-protein] S-malonyltransferase activity"
is_a: GO:0004312 ! fatty-acid synthase activity
is_a: GO:0016419 ! S-malonyltransferase activity

[Term]
id: GO:0004315
name: 3-oxoacyl-[acyl-carrier-protein] synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.41]
subset: gosubset_prok
synonym: "3-ketoacyl-acyl carrier protein synthase activity" EXACT [EC:2.3.1.41]
synonym: "3-oxoacyl-[acyl-carrier protein] synthase activity" EXACT []
synonym: "3-oxoacyl-ACP synthase activity" EXACT []
synonym: "3-oxoacyl-acyl-carrier-protein synthase activity" EXACT [EC:2.3.1.41]
synonym: "3-oxoacyl:ACP synthase I" RELATED [EC:2.3.1.41]
synonym: "acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)" EXACT [EC:2.3.1.41]
synonym: "acyl-malonyl acyl carrier protein-condensing enzyme activity" EXACT [EC:2.3.1.41]
synonym: "acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity" EXACT [EC:2.3.1.41]
synonym: "beta-ketoacyl acyl carrier protein synthase activity" EXACT [EC:2.3.1.41]
synonym: "beta-ketoacyl synthetase activity" EXACT [EC:2.3.1.41]
synonym: "beta-ketoacyl-[acyl carrier protein] synthase activity" EXACT [EC:2.3.1.41]
synonym: "beta-ketoacyl-ACP synthase I activity" EXACT [EC:2.3.1.41]
synonym: "beta-ketoacyl-ACP synthetase activity" EXACT [EC:2.3.1.41]
synonym: "beta-ketoacyl-acyl carrier protein synthase activity" EXACT [EC:2.3.1.41]
synonym: "beta-ketoacyl-acyl carrier protein synthetase activity" EXACT [EC:2.3.1.41]
synonym: "beta-ketoacyl-acyl-carrier-protein synthase I" RELATED [EC:2.3.1.41]
synonym: "beta-ketoacylsynthase activity" EXACT [EC:2.3.1.41]
synonym: "condensing enzyme activity" BROAD [EC:2.3.1.41]
synonym: "FabB" RELATED [EC:2.3.1.41]
synonym: "FabF1" RELATED [EC:2.3.1.41]
synonym: "fatty acid condensing enzyme activity" BROAD [EC:2.3.1.41]
synonym: "KAS I activity" NARROW [EC:2.3.1.41]
synonym: "KASI" RELATED [EC:2.3.1.41]
synonym: "ketoacyl-ACP synthase activity" EXACT []
xref: EC:2.3.1.41
xref: MetaCyc:3-OXOACYL-ACP-SYNTH-RXN
xref: Reactome:76136 "3-oxoacyl-[acyl-carrier-protein] synthase activity"
is_a: GO:0004312 ! fatty-acid synthase activity

[Term]
id: GO:0004316
name: 3-oxoacyl-[acyl-carrier-protein] reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]
subset: gosubset_prok
synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.100]
synonym: "3-ketoacyl acyl carrier protein reductase activity" EXACT [EC:1.1.1.100]
synonym: "3-oxoacyl-[acyl-carrier protein] reductase activity" EXACT []
synonym: "3-oxoacyl-ACP reductase activity" EXACT []
synonym: "3-oxoacyl-ACPreductase activity" EXACT [EC:1.1.1.100]
synonym: "3-oxoacyl-acyl-carrier-protein reductase activity" EXACT [EC:1.1.1.100]
synonym: "beta-ketoacyl acyl carrier protein (ACP) reductase activity" EXACT [EC:1.1.1.100]
synonym: "beta-ketoacyl reductase activity" EXACT [EC:1.1.1.100]
synonym: "beta-ketoacyl thioester reductase activity" EXACT [EC:1.1.1.100]
synonym: "beta-ketoacyl-ACP reductase activity" EXACT [EC:1.1.1.100]
synonym: "beta-ketoacyl-acyl carrier protein reductase activity" EXACT [EC:1.1.1.100]
synonym: "beta-ketoacyl-acyl-carrier protein(ACP) reductase activity" EXACT [EC:1.1.1.100]
synonym: "NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity" EXACT [EC:1.1.1.100]
xref: EC:1.1.1.100
xref: MetaCyc:3-OXOACYL-ACP-REDUCT-RXN
xref: Reactome:76148 "3-oxoacyl-[acyl-carrier-protein] reductase activity"
is_a: GO:0004312 ! fatty-acid synthase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004317
name: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.61]
synonym: "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.61]
synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.61]
synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.61]
synonym: "3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity" EXACT []
synonym: "3-hydroxypalmitoyl-ACP dehydratase activity" EXACT []
synonym: "3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.61]
synonym: "beta-hydroxypalmitoyl thioester dehydratase activity" EXACT [EC:4.2.1.61]
synonym: "beta-hydroxypalmitoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.61]
synonym: "beta-hydroxypalmityl-ACP dehydrase activity" EXACT [EC:4.2.1.61]
synonym: "D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity" EXACT [EC:4.2.1.61]
synonym: "D-3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.61]
xref: EC:4.2.1.61
xref: MetaCyc:4.2.1.61-RXN
is_a: GO:0004312 ! fatty-acid synthase activity
is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity

[Term]
id: GO:0004318
name: enoyl-[acyl-carrier-protein] reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+." [EC:1.3.1.9]
subset: gosubset_prok
synonym: "acyl-acyl-carrier-protein:NAD+ oxidoreductase" EXACT [EC:1.3.1.9]
synonym: "enoyl-[acyl-carrier protein] reductase (NADH) activity" EXACT [EC:1.3.1.9]
synonym: "enoyl-ACP reductase (NADH) activity" EXACT [EC:1.3.1.9]
synonym: "enoyl-acyl-carrier-protein reductase (NADH)" EXACT [EC:1.3.1.9]
synonym: "NADH-enoyl acyl carrier protein reductase activity" EXACT [EC:1.3.1.9]
synonym: "NADH-specific enoyl-ACP reductase activity" EXACT [EC:1.3.1.9]
xref: EC:1.3.1.9
xref: MetaCyc:ENOYL-ACP-REDUCT-NADH-RXN
is_a: GO:0004312 ! fatty-acid synthase activity
is_a: GO:0016631 ! enoyl-[acyl-carrier-protein] reductase activity

[Term]
id: GO:0004319
name: enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10]
subset: gosubset_prok
synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)" EXACT [EC:1.3.1.10]
synonym: "enoyl acyl-carrier-protein reductase activity" EXACT [EC:1.3.1.10]
synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity" EXACT []
synonym: "enoyl-ACP reductase (NADPH, B-specific) activity" EXACT []
synonym: "enoyl-acyl-carrier-protein reductase (NADPH, B-specific)" EXACT [EC:1.3.1.10]
synonym: "enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)" EXACT [EC:1.3.1.10]
synonym: "NADPH 2-enoyl Co A reductase activity" EXACT [EC:1.3.1.10]
synonym: "reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.10]
xref: EC:1.3.1.10
xref: MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN
xref: Reactome:76151 "enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity"
is_a: GO:0004312 ! fatty-acid synthase activity
is_a: GO:0016631 ! enoyl-[acyl-carrier-protein] reductase activity

[Term]
id: GO:0004320
name: oleoyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate." [EC:3.1.2.14]
subset: gosubset_prok
synonym: "oleoyl-[acyl-carrier protein] hydrolase activity" EXACT []
synonym: "oleoyl-ACP hydrolase activity" EXACT []
synonym: "oleoyl-ACP thioesterase activity" EXACT [EC:3.1.2.14]
synonym: "oleoyl-acyl carrier protein thioesterase activity" EXACT [EC:3.1.2.14]
synonym: "oleoyl-acyl-carrier-protein hydrolase" BROAD [EC:3.1.2.14]
xref: EC:3.1.2.14
xref: MetaCyc:3.1.2.14-RXN
xref: MetaCyc:PWY-5142
xref: Reactome:76154 "oleoyl-[acyl-carrier-protein] hydrolase activity"
is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity

[Term]
id: GO:0004321
name: fatty-acyl-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86]
synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)" EXACT [EC:2.3.1.86]
synonym: "yeast fatty acid synthase activity" NARROW [EC:2.3.1.86]
xref: EC:2.3.1.86
xref: MetaCyc:FATTY-ACYL-COA-SYNTHASE-RXN
is_a: GO:0016408 ! C-acyltransferase activity

[Term]
id: GO:0004322
name: ferroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1]
subset: gosubset_prok
synonym: "caeruloplasmin" RELATED [EC:1.16.3.1]
synonym: "ceruloplasmin activity" NARROW [EC:1.16.3.1]
synonym: "Fe(II):oxygen oxidoreductase activity" EXACT [EC:1.16.3.1]
synonym: "ferro:O2 oxidoreductase activity" EXACT [EC:1.16.3.1]
synonym: "ferroxidase I" RELATED [EC:1.16.3.1]
synonym: "ferroxidase, iron II:oxygen oxidoreductase activity" EXACT [EC:1.16.3.1]
synonym: "iron(II): oxygen oxidoreductase activity" EXACT [EC:1.16.3.1]
synonym: "multicopper ferroxidase iron transport mediator activity" NARROW []
xref: EC:1.16.3.1
xref: MetaCyc:RXN0-1483
is_a: GO:0016724 ! oxidoreductase activity, oxidizing metal ions, oxygen as acceptor

[Term]
id: GO:0004323
name: multicopper ferroxidase iron transport mediator activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0004322
consider: GO:0005381

[Term]
id: GO:0004324
name: ferredoxin-NADP+ reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+." [EC:1.18.1.2, GOC:kd]
comment: Note that this term specifically refers to the reaction proceeding in the direction shown; it should therefore be used to annotate gene products that catalyze the oxidation of reduced ferredoxin or adrenodoxin; also consider annotating to the molecular function term 'NADPH-adrenodoxin reductase activity ; GO:0015039'.
subset: gosubset_prok
synonym: "ferredoxin-NADP oxidoreductase activity" EXACT [EC:1.18.1.2]
synonym: "ferredoxin-NADP reductase activity" EXACT []
synonym: "ferredoxin-NADP-oxidoreductase activity" EXACT [EC:1.18.1.2]
synonym: "ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity" EXACT [EC:1.18.1.2]
synonym: "ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity" EXACT [EC:1.18.1.2]
synonym: "ferredoxin-TPN reductase activity" EXACT [EC:1.18.1.2]
synonym: "ferredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.18.1.2]
synonym: "NADP:ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.2]
synonym: "NADPH:ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.2]
synonym: "reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity" EXACT [EC:1.18.1.2]
synonym: "TPNH-ferredoxin reductase activity" EXACT [EC:1.18.1.2]
xref: EC:1.18.1.2
xref: MetaCyc:1.18.1.2-RXN
is_a: GO:0008937 ! ferredoxin reductase activity

[Term]
id: GO:0004325
name: ferrochelatase activity
namespace: molecular_function
def: "Catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+." [EC:4.99.1.1]
subset: gosubset_prok
synonym: "ferro-protoporphyrin chelatase activity" EXACT [EC:4.99.1.1]
synonym: "heme synthase activity" EXACT [EC:4.99.1.1]
synonym: "heme synthetase activity" EXACT [EC:4.99.1.1]
synonym: "iron chelatase activity" EXACT [EC:4.99.1.1]
synonym: "protoheme ferro-lyase (protoporphyrin-forming)" EXACT [EC:4.99.1.1]
synonym: "protoheme ferro-lyase activity" EXACT [EC:4.99.1.1]
synonym: "protoheme ferrolyase activity" EXACT [EC:4.99.1.1]
xref: EC:4.99.1.1
xref: MetaCyc:PROTOHEMEFERROCHELAT-RXN
xref: Reactome:10394 "ferrochelatase activity"
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0004326
name: tetrahydrofolylpolyglutamate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)." [EC:6.3.2.17]
subset: gosubset_prok
synonym: "folate polyglutamate synthetase activity" EXACT [EC:6.3.2.17]
synonym: "folylpoly(gamma-glutamate) synthase activity" EXACT [EC:6.3.2.17]
synonym: "folylpoly-gamma-glutamate synthase activity" EXACT [EC:6.3.2.17]
synonym: "folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity" EXACT [EC:6.3.2.17]
synonym: "folylpolyglutamate synthase activity" EXACT []
synonym: "folylpolyglutamate synthetase activity" EXACT [EC:6.3.2.17]
synonym: "folylpolyglutamyl synthetase activity" EXACT [EC:6.3.2.17]
synonym: "formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17]
synonym: "FPGS activity" EXACT [EC:6.3.2.17]
synonym: "N(10)-formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17]
synonym: "N10-formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17]
synonym: "tetrahydrofolate synthase activity" EXACT [EC:6.3.2.17]
synonym: "tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.17]
synonym: "tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.17]
synonym: "tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.17]
xref: EC:6.3.2.17
xref: MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN
xref: Reactome:10396 "tetrahydrofolylpolyglutamate synthase activity"
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004327
name: formaldehyde dehydrogenase (glutathione) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+." [EC:1.2.1.1]
comment: This term was made obsolete because it was derived from an EC entry (1.2.1.1) that has since been split into two entries.
subset: gosubset_prok
xref: UM-BBD_enzymeID:e0028
is_obsolete: true
consider: GO:0051903
consider: GO:0051907

[Term]
id: GO:0004328
name: formamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: formamide + H2O = formate + NH3." [EC:3.5.1.49]
subset: gosubset_prok
synonym: "formamide amidohydrolase activity" EXACT [EC:3.5.1.49]
xref: EC:3.5.1.49
xref: MetaCyc:FORMAMIDASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004329
name: formate-tetrahydrofolate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate." [EC:6.3.4.3]
subset: gosubset_prok
synonym: "10-formyl-THF synthetase activity" EXACT [GOC:vw]
synonym: "10-formyltetrahydrofolate synthetase activity" EXACT [EC:6.3.4.3]
synonym: "formate:tetrahydrofolate ligase (ADP-forming)" EXACT [EC:6.3.4.3]
synonym: "formyltetrahydrofolate synthetase activity" EXACT [EC:6.3.4.3]
synonym: "tetrahydrofolate formylase activity" EXACT [EC:6.3.4.3]
synonym: "tetrahydrofolic formylase activity" EXACT [EC:6.3.4.3]
xref: EC:6.3.4.3
xref: MetaCyc:FORMATETHFLIG-RXN
xref: Reactome:10407 "formate-tetrahydrofolate ligase activity"
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004331
name: fructose-2,6-bisphosphate 2-phosphatase activity
namespace: molecular_function
alt_id: GO:0004330
def: "Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.46]
subset: gosubset_prok
synonym: "beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.46]
synonym: "D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.46]
synonym: "fructose-2,6-bisphosphatase activity" EXACT [EC:3.1.3.46]
xref: EC:3.1.3.46
xref: MetaCyc:3.1.3.46-RXN
xref: Reactome:10434 "fructose-2,6-bisphosphate 2-phosphatase activity"
is_a: GO:0019203 ! carbohydrate phosphatase activity

[Term]
id: GO:0004332
name: fructose-bisphosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.13]
subset: gosubset_prok
synonym: "1,6-diphosphofructose aldolase activity" EXACT [EC:4.1.2.13]
synonym: "aldolase activity" BROAD [EC:4.1.2.13]
synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.13]
synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.13]
synonym: "diphosphofructose aldolase activity" EXACT [EC:4.1.2.13]
synonym: "fructoaldolase activity" EXACT [EC:4.1.2.13]
synonym: "fructose 1,6-diphosphate aldolase activity" EXACT [EC:4.1.2.13]
synonym: "fructose 1-monophosphate aldolase activity" EXACT [EC:4.1.2.13]
synonym: "fructose 1-phosphate aldolase activity" EXACT [EC:4.1.2.13]
synonym: "fructose diphosphate aldolase activity" EXACT [EC:4.1.2.13]
synonym: "fructose-1,6-bisphosphate triosephosphate-lyase activity" EXACT [EC:4.1.2.13]
synonym: "ketose 1-phosphate aldolase activity" EXACT [EC:4.1.2.13]
synonym: "phosphofructoaldolase activity" EXACT [EC:4.1.2.13]
synonym: "SMALDO" RELATED [EC:4.1.2.13]
synonym: "zymohexase activity" EXACT [EC:4.1.2.13]
xref: EC:4.1.2.13
xref: MetaCyc:F16ALDOLASE-RXN
xref: Reactome:10435 "fructose-bisphosphate aldolase activity"
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0004333
name: fumarate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate = fumarate + H2O." [EC:4.2.1.2]
subset: gosubset_prok
synonym: "(S)-malate hydro-lyase (fumarate-forming)" EXACT [EC:4.2.1.2]
synonym: "(S)-malate hydro-lyase activity" EXACT [EC:4.2.1.2]
synonym: "fumarase activity" EXACT [EC:4.2.1.2]
synonym: "L-malate hydro-lyase activity" EXACT [EC:4.2.1.2]
xref: EC:4.2.1.2
xref: MetaCyc:FUMHYDR-RXN
xref: Reactome:10436 "fumarate hydratase activity"
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004334
name: fumarylacetoacetase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate." [EC:3.7.1.2]
subset: gosubset_prok
synonym: "4-fumarylacetoacetate fumarylhydrolase activity" EXACT [EC:3.7.1.2]
synonym: "beta-diketonase activity" EXACT [EC:3.7.1.2]
synonym: "fumarylacetoacetate hydrolase activity" EXACT [EC:3.7.1.2]
xref: EC:3.7.1.2
xref: MetaCyc:FUMARYLACETOACETASE-RXN
xref: Reactome:10438 "fumarylacetoacetase activity"
xref: UM-BBD_enzymeID:e0083
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0004335
name: galactokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate." [EC:2.7.1.6]
subset: gosubset_prok
synonym: "ATP:D-galactose 1-phosphotransferase activity" EXACT [EC:2.7.1.6]
synonym: "ATP:D-galactose-1-phosphotransferase activity" EXACT [EC:2.7.1.6]
synonym: "galactokinase (phosphorylating)" EXACT [EC:2.7.1.6]
xref: EC:2.7.1.6
xref: MetaCyc:GALACTOKIN-RXN
xref: Reactome:10440 "galactokinase activity"
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0004336
name: galactosylceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine." [EC:3.2.1.46]
synonym: "beta-galactocerebrosidase activity" EXACT [EC:3.2.1.46]
synonym: "beta-galactosylceramidase activity" EXACT [EC:3.2.1.46]
synonym: "ceramide galactosidase activity" EXACT [EC:3.2.1.46]
synonym: "cerebroside beta-galactosidase activity" EXACT [EC:3.2.1.46]
synonym: "cerebroside galactosidase activity" EXACT [EC:3.2.1.46]
synonym: "D-galactosyl-N-acylsphingosine galactohydrolase activity" EXACT [EC:3.2.1.46]
synonym: "galactocerebrosidase activity" EXACT [EC:3.2.1.46]
synonym: "galactocerebroside beta-galactosidase activity" EXACT [EC:3.2.1.46]
synonym: "galactocerebroside galactosidase activity" EXACT [EC:3.2.1.46]
synonym: "galactocerebroside-beta-D-galactosidase activity" EXACT [EC:3.2.1.46]
synonym: "galactocerebroside.beta-galactosidase activity" EXACT [EC:3.2.1.46]
synonym: "galactosylceramidase I" RELATED [EC:3.2.1.46]
synonym: "galactosylceramide beta-galactosidase activity" EXACT [EC:3.2.1.46]
synonym: "galactosylceramide.beta-galactosidase activity" EXACT [EC:3.2.1.46]
synonym: "galactosylcerebrosidase activity" EXACT [EC:3.2.1.46]
synonym: "galcerase activity" EXACT [EC:3.2.1.46]
synonym: "lactosylceramidase activity" EXACT [EC:3.2.1.46]
synonym: "lactosylceramidase I" RELATED [EC:3.2.1.46]
xref: EC:3.2.1.46
xref: MetaCyc:GALACTOSYLCERAMIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
is_a: GO:0017040 ! ceramidase activity

[Term]
id: GO:0004337
name: geranyltranstransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate." [EC:2.5.1.10]
comment: Note that this is the second step in the formation of farnesyl diphosphate. The first step is 'dimethylallyltransferase activity ; GO:0004161'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'.
subset: gosubset_prok
synonym: "farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.10]
synonym: "farnesyl pyrophosphate synthetase activity" EXACT []
synonym: "farnesyl-diphosphate synthase activity" EXACT []
synonym: "farnesylpyrophosphate synthetase activity" EXACT [EC:2.5.1.10]
synonym: "FPP synthetase activity" EXACT [EC:2.5.1.10]
synonym: "geranyl transferase I" RELATED [EC:2.5.1.10]
synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity" EXACT [EC:2.5.1.10]
synonym: "geranyltransferase activity" EXACT [EC:2.5.1.10]
xref: EC:2.5.1.10
xref: MetaCyc:FPPSYN-RXN
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0004338
name: glucan 1,3-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose." [EC:3.2.1.58]
synonym: "1,3-beta-glucan glucohydrolase activity" EXACT [EC:3.2.1.58]
synonym: "beta-1,3-glucan exo-hydrolase activity" EXACT [EC:3.2.1.58]
synonym: "exo (1->3)-beta-glucanase activity" EXACT [EC:3.2.1.58]
synonym: "exo-1,3-beta-D-glucanase activity" EXACT [EC:3.2.1.58]
synonym: "exo-1,3-beta-glucanase activity" EXACT [EC:3.2.1.58]
synonym: "exo-1,3-beta-glucosidase activity" EXACT [EC:3.2.1.58]
synonym: "exo-beta-(1->3)-D-glucanase activity" EXACT [EC:3.2.1.58]
synonym: "exo-beta-(1->3)-glucanohydrolase activity" EXACT [EC:3.2.1.58]
synonym: "exo-beta-1,3-D-glucanase activity" EXACT [EC:3.2.1.58]
synonym: "exo-beta-1,3-glucanase activity" EXACT [EC:3.2.1.58]
xref: EC:3.2.1.58
xref: MetaCyc:3.2.1.58-RXN
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0004339
name: glucan 1,4-alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose." [EC:3.2.1.3]
comment: Note that this term is not a child of 'alpha-glucosidase activity ; GO:0004558', because in the reaction represented by GO:0004339 results in the release of beta-D-glucose, whereas in GO:0004558 alpha-D-glucose is released.
subset: gosubset_prok
synonym: "1,4-alpha-D-glucan glucohydrolase activity" EXACT [EC:3.2.1.3]
synonym: "amyloglucosidase activity" EXACT [EC:3.2.1.3]
synonym: "exo-1,4-alpha-glucosidase activity" EXACT [EC:3.2.1.3]
synonym: "gamma-1,4-glucan glucohydrolase activity" EXACT [EC:3.2.1.3]
synonym: "gamma-amylase activity" EXACT [EC:3.2.1.3]
synonym: "glucoamylase activity" EXACT []
synonym: "glucose amylase activity" EXACT [EC:3.2.1.3]
synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.3]
xref: EC:3.2.1.3
xref: MetaCyc:3.2.1.3-RXN
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0004340
name: glucokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose 6-phosphate." [EC:2.7.1.2]
subset: gosubset_prok
synonym: "ATP:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.2]
synonym: "glucokinase (phosphorylating)" EXACT [EC:2.7.1.2]
synonym: "glucose kinase activity" EXACT [EC:2.7.1.2]
xref: EC:2.7.1.2
xref: MetaCyc:GLUCOKIN-RXN
xref: Reactome:10457 "glucokinase activity"
is_a: GO:0004396 ! hexokinase activity

[Term]
id: GO:0004341
name: gluconolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate." [EC:3.1.1.17]
subset: gosubset_prok
synonym: "aldonolactonase activity" EXACT [EC:3.1.1.17]
synonym: "D-glucono-1,5-lactone lactonohydrolase activity" EXACT [EC:3.1.1.17]
synonym: "glucono-delta-lactonase activity" EXACT [EC:3.1.1.17]
synonym: "gulonolactonase activity" EXACT [EC:3.1.1.17]
synonym: "lactonase activity" BROAD [EC:3.1.1.17]
xref: EC:3.1.1.17
xref: MetaCyc:GLUCONOLACT-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0004342
name: glucosamine-6-phosphate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3." [EC:3.5.99.6]
comment: Note that this function was formerly EC:5.3.1.10.
subset: gosubset_prok
synonym: "2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)" EXACT [EC:3.5.99.6]
synonym: "aminodeoxyglucosephosphate isomerase activity" EXACT [EC:3.5.99.6]
synonym: "GlcN6P deaminase activity" EXACT [EC:3.5.99.6]
synonym: "glucosamine phosphate deaminase activity" EXACT [EC:3.5.99.6]
synonym: "glucosamine-6-phosphate isomerase activity" EXACT [EC:3.5.99.6]
synonym: "glucosaminephosphate isomerase" BROAD [EC:3.5.99.6]
synonym: "phosphoglucosamine isomerase activity" EXACT [EC:3.5.99.6]
synonym: "phosphoglucosaminisomerase activity" EXACT [EC:3.5.99.6]
xref: EC:3.5.99.6
xref: MetaCyc:GLUCOSAMINE-6-P-DEAMIN-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0004343
name: glucosamine 6-phosphate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate." [EC:2.3.1.4]
subset: gosubset_prok
synonym: "acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.4]
synonym: "aminodeoxyglucosephosphate acetyltransferase activity" EXACT [EC:2.3.1.4]
synonym: "D-glucosamine-6-P N-acetyltransferase activity" EXACT [EC:2.3.1.4]
synonym: "glucosamine 6-phosphate acetylase activity" EXACT [EC:2.3.1.4]
synonym: "glucosamine-6-phosphate acetylase activity" EXACT [EC:2.3.1.4]
synonym: "glucosamine-phosphate N-acetyltransferase activity" EXACT []
synonym: "N-acetylglucosamine-6-phosphate synthase activity" EXACT [EC:2.3.1.4]
synonym: "phosphoglucosamine acetylase activity" EXACT [EC:2.3.1.4]
synonym: "phosphoglucosamine N-acetylase activity" EXACT [EC:2.3.1.4]
synonym: "phosphoglucosamine transacetylase activity" EXACT [EC:2.3.1.4]
xref: EC:2.3.1.4
xref: MetaCyc:GLUCOSAMINEPNACETYLTRANS-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004344
name: glucose dehydrogenase activity
namespace: molecular_function
alt_id: GO:0008708
def: "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10]
synonym: "D-glucose:(acceptor) 1-oxidoreductase" EXACT [EC:1.1.99.10]
synonym: "D-glucose:acceptor 1-oxidoreductase" EXACT [EC:1.1.5.2]
synonym: "glucose dehydrogenase (acceptor) activity" EXACT []
synonym: "glucose dehydrogenase (Aspergillus) activity" NARROW [EC:1.1.99.10]
synonym: "glucose dehydrogenase (decarboxylating)" EXACT [EC:1.1.99.10]
xref: EC:1.1.-.-
xref: EC:1.1.99.10
xref: MetaCyc:GLUCOSE-DEHYDROGENASE-ACCEPTOR-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0004345
name: glucose-6-phosphate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49]
subset: gosubset_prok
synonym: "6-phosphoglucose dehydrogenas" RELATED []
synonym: "6-phosphoglucose dehydrogenase activity" EXACT []
synonym: "D-glucose 6-phosphate dehydrogenase activity" EXACT []
synonym: "D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.49]
synonym: "Entner-doudoroff enzyme" RELATED [EC:1.1.1.49]
synonym: "G6PD activity" EXACT [EC:1.1.1.49]
synonym: "G6PDH" EXACT []
synonym: "GDH" RELATED []
synonym: "glucose 6-phosphate dehydrogenase (NADP) activity" EXACT []
synonym: "glucose-6-phosphate 1-dehydrogenase activity" EXACT []
synonym: "NADP-dependent glucose 6-phosphate dehydrogenase activity" EXACT []
synonym: "NADP-glucose-6-phosphate dehydrogenase activity" EXACT []
synonym: "Zwischenferment" RELATED []
synonym: "zwischenferment" RELATED [EC:1.1.1.49]
xref: EC:1.1.1.49
xref: MetaCyc:GLU6PDEHYDROG-RXN
xref: Reactome:10468 "glucose-6-phosphate dehydrogenase activity"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004346
name: glucose-6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.9]
subset: gosubset_prok
synonym: "D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.9]
synonym: "glucose 6-phosphate phosphatase activity" EXACT [EC:3.1.3.9]
xref: EC:3.1.3.9
xref: MetaCyc:GLUCOSE-6-PHOSPHATASE-RXN
xref: Reactome:10470 "glucose-6-phosphatase activity"
is_a: GO:0019203 ! carbohydrate phosphatase activity

[Term]
id: GO:0004347
name: glucose-6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.9]
subset: gosubset_prok
synonym: "D-glucose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.9]
synonym: "D-glucose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.9]
synonym: "glucose phosphate isomerase activity" EXACT [EC:5.3.1.9]
synonym: "hexose monophosphate isomerase activity" BROAD [EC:5.3.1.9]
synonym: "hexose phosphate isomerase activity" EXACT [EC:5.3.1.9]
synonym: "hexosephosphate isomerase activity" BROAD [EC:5.3.1.9]
synonym: "oxoisomerase activity" RELATED [EC:5.3.1.9]
synonym: "phosphoglucoisomerase activity" EXACT [EC:5.3.1.9]
synonym: "phosphoglucose isomerase activity" EXACT [EC:5.3.1.9]
synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.9]
synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.9]
synonym: "phosphohexose isomerase activity" BROAD [EC:5.3.1.9]
synonym: "phosphosaccharomutase activity" BROAD [EC:5.3.1.9]
xref: EC:5.3.1.9
xref: MetaCyc:PGLUCISOM-RXN
xref: Reactome:10472 "glucose-6-phosphate isomerase activity"
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004348
name: glucosylceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45]
subset: gosubset_prok
synonym: "acid beta-glucosidase activity" EXACT [EC:3.2.1.45]
synonym: "beta-D-glucocerebrosidase activity" EXACT [EC:3.2.1.45]
synonym: "beta-glucocerebrosidase activity" EXACT [EC:3.2.1.45]
synonym: "beta-glucosylceramidase activity" EXACT [EC:3.2.1.45]
synonym: "ceramide glucosidase activity" EXACT [EC:3.2.1.45]
synonym: "D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [EC:3.2.1.45]
synonym: "GlcCer-beta-glucosidase activity" EXACT [EC:3.2.1.45]
synonym: "glucocerebrosidase activity" EXACT [EC:3.2.1.45]
synonym: "glucosphingosine glucosylhydrolase activity" EXACT [EC:3.2.1.45]
synonym: "glucosylcerebrosidase activity" EXACT [EC:3.2.1.45]
synonym: "glucosylsphingosine beta-D-glucosidase activity" EXACT [EC:3.2.1.45]
synonym: "glucosylsphingosine beta-glucosidase activity" EXACT [EC:3.2.1.45]
synonym: "psychosine hydrolase activity" EXACT [EC:3.2.1.45]
xref: EC:3.2.1.45
xref: MetaCyc:GLUCOSYLCERAMIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
is_a: GO:0017040 ! ceramidase activity

[Term]
id: GO:0004349
name: glutamate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate." [EC:2.7.2.11]
subset: gosubset_prok
synonym: "ATP-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.11]
synonym: "ATP:gamma-L-glutamate phosphotransferase activity" EXACT [EC:2.7.2.11]
synonym: "ATP:L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.11]
synonym: "gamma-glutamate kinase activity" EXACT [EC:2.7.2.11]
synonym: "gamma-glutamyl kinase activity" EXACT [EC:2.7.2.11]
synonym: "glutamate kinase activity" EXACT [EC:2.7.2.11]
xref: EC:2.7.2.11
xref: MetaCyc:GLUTKIN-RXN
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor
is_a: GO:0019202 ! amino acid kinase activity

[Term]
id: GO:0004350
name: glutamate-5-semialdehyde dehydrogenase activity
namespace: molecular_function
alt_id: GO:0001513
def: "Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+." [EC:1.2.1.41]
subset: gosubset_prok
synonym: "beta-glutamylphosphate reductase activity" EXACT [EC:1.2.1.41]
synonym: "gamma-glutamyl phosphate reductase activity" EXACT [EC:1.2.1.41]
synonym: "gamma-glutamylphosphate reductase activity" EXACT [EC:1.2.1.41]
synonym: "glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41]
synonym: "glutamate-gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41]
synonym: "glutamate-phosphate reductase activity" EXACT []
synonym: "glutamyl-gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41]
synonym: "glutamylphosphate reductase activity" EXACT []
synonym: "L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.41]
xref: EC:1.2.1.41
xref: MetaCyc:GLUTSEMIALDEHYDROG-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004351
name: glutamate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2." [EC:4.1.1.15]
subset: gosubset_prok
synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.15]
synonym: "cysteic acid decarboxylase activity" EXACT [EC:4.1.1.15]
synonym: "gamma-glutamate decarboxylase activity" EXACT [EC:4.1.1.15]
synonym: "L-aspartate-alpha-decarboxylase activity" EXACT [EC:4.1.1.15]
synonym: "L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)" EXACT [EC:4.1.1.15]
synonym: "L-glutamate 1-carboxy-lyase activity" EXACT [EC:4.1.1.15]
synonym: "L-glutamate alpha-decarboxylase activity" EXACT [EC:4.1.1.15]
synonym: "L-glutamic acid decarboxylase activity" EXACT [EC:4.1.1.15]
synonym: "L-glutamic decarboxylase activity" EXACT [EC:4.1.1.15]
xref: EC:4.1.1.15
xref: MetaCyc:GLUTDECARBOX-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004352
name: glutamate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+." [EC:1.4.1.2]
subset: gosubset_prok
synonym: "glutamate dehydrogenase (NAD)" EXACT [EC:1.4.1.2]
synonym: "glutamate oxidoreductase activity" EXACT [EC:1.4.1.2]
synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.2]
synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.2]
synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.2]
synonym: "L-glutamate:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.2]
synonym: "NAD-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.2]
synonym: "NAD-dependent glutamic dehydrogenase activity" EXACT [EC:1.4.1.2]
synonym: "NAD-glutamate dehydrogenase activity" EXACT [EC:1.4.1.2]
synonym: "NAD-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2]
synonym: "NAD-linked glutamic dehydrogenase activity" EXACT [EC:1.4.1.2]
synonym: "NAD-specific glutamate dehydrogenase activity" EXACT [EC:1.4.1.2]
synonym: "NAD-specific glutamic dehydrogenase activity" EXACT [EC:1.4.1.2]
synonym: "NAD:glutamate oxidoreductase activity" EXACT [EC:1.4.1.2]
synonym: "NADH-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2]
xref: EC:1.4.1.2
xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004353
name: glutamate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." [EC:1.4.1.3]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
subset: gosubset_prok
synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" RELATED []
synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" RELATED []
synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.3]
synonym: "L-glutamate:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.3]
xref: EC:1.4.1.3
xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN
xref: MetaCyc:GLUTAMATE-SYN2-PWY
xref: Reactome:10485 "glutamate dehydrogenase [NAD(P)+] activity"
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004354
name: glutamate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+." [EC:1.4.1.4]
subset: gosubset_prok
synonym: "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.4.1.4]
synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.4]
synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.4]
synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.4]
synonym: "L-glutamate:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.4]
synonym: "L-glutamic acid dehydrogenase activity" EXACT [EC:1.4.1.4]
synonym: "NAD(P)-glutamate dehydrogenase activity" EXACT [EC:1.4.1.4]
synonym: "NAD(P)H-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.4]
xref: EC:1.4.1.4
xref: MetaCyc:GLUTDEHYD-RXN
xref: MetaCyc:GLUTSYNIII-PWY
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004355
name: glutamate synthase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH + H+." [EC:1.4.1.13]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
subset: gosubset_prok
synonym: "glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity" EXACT [EC:1.4.1.13]
synonym: "glutamate synthetase (NADP) activity" EXACT [EC:1.4.1.13]
synonym: "glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity" EXACT [EC:1.4.1.13]
synonym: "glutamine-ketoglutaric aminotransferase activity" EXACT [EC:1.4.1.13]
synonym: "GOGAT activity" EXACT [EC:1.4.1.13]
synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.13]
synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.13]
synonym: "L-glutamate:NADP+ oxidoreductase (transaminating)" EXACT [EC:1.4.1.13]
synonym: "L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity" EXACT [EC:1.4.1.13]
synonym: "NADPH-dependent glutamate synthase activity" EXACT [EC:1.4.1.13]
synonym: "NADPH-glutamate synthase activity" EXACT [EC:1.4.1.13]
synonym: "NADPH-linked glutamate synthase" EXACT [EC:1.4.1.13]
xref: EC:1.4.1.13
xref: MetaCyc:GLUGLNSYN-PWY
xref: MetaCyc:GLUTAMATESYN-RXN
xref: MetaCyc:GLUTSYN-PWY
is_a: GO:0045181 ! glutamate synthase activity, NADH or NADPH as acceptor

[Term]
id: GO:0004356
name: glutamate-ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine." [EC:6.3.1.2]
subset: gosubset_prok
synonym: "glutamine synthetase activity" EXACT []
synonym: "glutamylhydroxamic synthetase activity" EXACT [EC:6.3.1.2]
synonym: "L-glutamate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.2]
synonym: "L-glutamine synthetase activity" EXACT [EC:6.3.1.2]
xref: EC:6.3.1.2
xref: MetaCyc:GLUTAMINESYN-RXN
xref: Reactome:10495 "glutamate-ammonia ligase activity"
is_a: GO:0016211 ! ammonia ligase activity

[Term]
id: GO:0004357
name: glutamate-cysteine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine." [EC:6.3.2.2]
subset: gosubset_prok
synonym: "gamma-glutamyl-L-cysteine synthetase activity" EXACT [EC:6.3.2.2]
synonym: "gamma-glutamylcysteine synthetase activity" EXACT [EC:6.3.2.2]
synonym: "gamma-glutamylcysteinyl synthetase activity" EXACT [EC:6.3.2.2]
synonym: "L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.2]
xref: EC:6.3.2.2
xref: MetaCyc:GLUTCYSLIG-RXN
xref: Reactome:10497 "glutamate-cysteine ligase activity"
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004358
name: glutamate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L-glutamate." [EC:2.3.1.35]
subset: gosubset_prok
synonym: "2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35]
synonym: "acetylglutamate synthetase activity" EXACT [EC:2.3.1.35]
synonym: "acetylglutamate-acetylornithine transacetylase activity" EXACT [EC:2.3.1.35]
synonym: "acetylglutamic synthetase activity" EXACT [EC:2.3.1.35]
synonym: "acetylglutamic-acetylornithine transacetylase activity" EXACT [EC:2.3.1.35]
synonym: "acetylornithinase activity" BROAD [EC:2.3.1.35]
synonym: "acetylornithine glutamate acetyltransferase activity" EXACT [EC:2.3.1.35]
synonym: "alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35]
synonym: "glutamate acetyltransferase activity" EXACT [EC:2.3.1.35]
synonym: "N-acetyl-L-glutamate synthetase activity" BROAD [EC:2.3.1.35]
synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.35]
synonym: "N-acetylglutamate synthetase activity" BROAD [EC:2.3.1.35]
synonym: "N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35]
synonym: "ornithine acetyltransferase activity" EXACT [EC:2.3.1.35]
synonym: "ornithine transacetylase activity" EXACT [EC:2.3.1.35]
xref: EC:2.3.1.35
xref: MetaCyc:GLUTAMATE-N-ACETYLTRANSFERASE-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004359
name: glutaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3." [EC:3.5.1.2]
subset: gosubset_prok
synonym: "glutaminase I" RELATED [EC:3.5.1.2]
synonym: "glutamine aminohydrolase activity" EXACT [EC:3.5.1.2]
synonym: "L-glutaminase activity" EXACT [EC:3.5.1.2]
synonym: "L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.2]
xref: EC:3.5.1.2
xref: MetaCyc:GLUTAMIN-RXN
xref: Reactome:10219 "glutaminase activity"
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004360
name: glutamine-fructose-6-phosphate transaminase (isomerizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate." [EC:2.6.1.16]
subset: gosubset_prok
synonym: "D-fructose-6-phosphate amidotransferase activity" EXACT [EC:2.6.1.16]
synonym: "GlcN6P synthase activity" EXACT [EC:2.6.1.16]
synonym: "glucosamine 6-phosphate synthase activity" EXACT [EC:2.6.1.16]
synonym: "glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity" EXACT [EC:2.6.1.16]
synonym: "glucosamine-6-phosphate isomerase (glutamine-forming) activity" EXACT []
synonym: "glucosamine-6-phosphate synthase activity" EXACT [EC:2.6.1.16]
synonym: "glucosaminephosphate isomerase" BROAD [EC:2.6.1.16]
synonym: "hexosephosphate aminotransferase activity" EXACT [EC:2.6.1.16]
synonym: "L-glutamine-D-fructose-6-phosphate amidotransferase activity" EXACT [EC:2.6.1.16]
synonym: "L-glutamine:D-fructose-6-phosphate isomerase (deaminating)" EXACT [EC:2.6.1.16]
xref: EC:2.6.1.16
xref: MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004361
name: glutaryl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor." [EC:1.3.99.7]
subset: gosubset_prok
synonym: "glutaryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.7]
synonym: "glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.7]
synonym: "glutaryl-CoA:acceptor 2,3-oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.7]
xref: EC:1.3.99.7
xref: MetaCyc:GLUTARYL-COA-DEHYDROGENASE-RXN
xref: Reactome:10507 "glutaryl-CoA dehydrogenase activity"
xref: UM-BBD_enzymeID:e0123
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0004362
name: glutathione-disulfide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [EC:1.8.1.7, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that this function was formerly EC:1.6.4.2.
subset: gosubset_prok
synonym: "glutathione reductase (NADPH) activity" EXACT []
synonym: "glutathione reductase activity" EXACT []
synonym: "glutathione S-reductase activity" EXACT [EC:1.8.1.7]
synonym: "glutathione-disulphide reductase activity" EXACT []
synonym: "glutathione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.7]
synonym: "GSH reductase activity" EXACT [EC:1.8.1.7]
synonym: "GSSG reductase activity" EXACT [EC:1.8.1.7]
synonym: "NADPH-glutathione reductase activity" EXACT [EC:1.8.1.7]
synonym: "NADPH-GSSG reductase activity" EXACT [EC:1.8.1.7]
synonym: "NADPH:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.1.7]
synonym: "oxidized glutathione reduction" RELATED []
xref: EC:1.8.1.7
xref: MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN
xref: Reactome:10508 "glutathione-disulfide reductase activity"
is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004363
name: glutathione synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione." [EC:6.3.2.3]
subset: gosubset_prok
synonym: "gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)" EXACT [EC:6.3.2.3]
synonym: "glutathione synthetase activity" EXACT [EC:6.3.2.3]
synonym: "GSH synthetase activity" EXACT [EC:6.3.2.3]
xref: EC:6.3.2.3
xref: MetaCyc:GLUTATHIONE-SYN-RXN
xref: Reactome:10524 "glutathione synthase activity"
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004364
name: glutathione transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]
subset: gosubset_prok
synonym: "glutathione conjugation reaction" EXACT []
synonym: "glutathione S-alkyl transferase activity" EXACT [EC:2.5.1.18]
synonym: "glutathione S-alkyltransferase activity" EXACT [EC:2.5.1.18]
synonym: "glutathione S-aralkyltransferase activity" EXACT [EC:2.5.1.18]
synonym: "glutathione S-aryltransferase activity" EXACT [EC:2.5.1.18]
synonym: "glutathione S-transferase activity" EXACT [EC:2.5.1.18]
synonym: "RX:glutathione R-transferase activity" EXACT [EC:2.5.1.18]
synonym: "S-(hydroxyalkyl)glutathione lyase activity" EXACT [EC:2.5.1.18]
xref: EC:2.5.1.18
xref: MetaCyc:GSHTRAN-RXN
xref: Reactome:10527 "glutathione transferase activity"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004365
name: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+." [EC:1.2.1.12]
subset: gosubset_prok
synonym: "3-phosphoglyceraldehyde dehydrogenase activity" EXACT [EC:1.2.1.12]
synonym: "D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.12]
synonym: "dehydrogenase, glyceraldehyde phosphate" EXACT [EC:1.2.1.12]
synonym: "GAPDH activity" EXACT [EC:1.2.1.12]
synonym: "glyceraldehyde phosphate dehydrogenase (NAD)" EXACT [EC:1.2.1.12]
synonym: "glyceraldehyde-3-P-dehydrogenase activity" EXACT [EC:1.2.1.12]
synonym: "NAD-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.12]
synonym: "NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.12]
synonym: "NADH-glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.12]
synonym: "phosphoglyceraldehyde dehydrogenase activity" EXACT [EC:1.2.1.12]
synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.12]
xref: EC:1.2.1.12
xref: MetaCyc:GAPOXNPHOSPHN-RXN
xref: Reactome:10530 "glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity"
is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity

[Term]
id: GO:0004366
name: glycerol-3-phosphate O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate." [EC:2.3.1.15]
subset: gosubset_prok
synonym: "3-glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15]
synonym: "ACP:sn-glycerol-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15]
synonym: "acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity" EXACT [EC:2.3.1.15]
synonym: "alpha-glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15]
synonym: "glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15]
synonym: "glycerol phosphate acyltransferase activity" EXACT [EC:2.3.1.15]
synonym: "glycerol phosphate transacylase activity" EXACT [EC:2.3.1.15]
synonym: "glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15]
synonym: "glycerophosphate transacylase activity" EXACT [EC:2.3.1.15]
synonym: "sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15]
synonym: "sn-glycerol-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15]
xref: EC:2.3.1.15
xref: MetaCyc:RXN-1381
xref: Reactome:10531 "glycerol-3-phosphate O-acyltransferase activity"
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0004367
name: glycerol-3-phosphate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+." [EC:1.1.1.8]
subset: gosubset_prok
synonym: "alpha-glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8]
synonym: "alpha-glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8]
synonym: "glycerol 1-phosphate dehydrogenase activity" RELATED [EC:1.1.1.8]
synonym: "glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8]
synonym: "glycerol-3-phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8]
synonym: "glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8]
synonym: "hydroglycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "L-alpha-glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "L-alpha-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "L-glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "L-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "NAD-alpha-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "NAD-dependent glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "NAD-dependent glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "NAD-L-glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "NAD-linked glycerol 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8]
synonym: "NADH-dihydroxyacetone phosphate reductase activity" RELATED [EC:1.1.1.8]
xref: EC:1.1.1.8
xref: MetaCyc:1.1.1.8-RXN
xref: Reactome:10533 "glycerol-3-phosphate dehydrogenase (NAD+) activity"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004368
name: glycerol-3-phosphate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor." [EC:1.1.99.5]
subset: gosubset_prok
synonym: "alpha-glycerophosphate dehydrogenase" EXACT [EC:1.1.99.5]
synonym: "alpha-glycerophosphate dehydrogenase (acceptor)" EXACT [EC:1.1.99.5]
synonym: "dehydrogenase, glycerol phosphate (acceptor)" EXACT [EC:1.1.99.5]
synonym: "DL-glycerol 3-phosphate oxidase" EXACT [EC:1.1.99.5]
synonym: "FAD-dependent glycerol-3-phosphate dehydrogenase" NARROW [EC:1.1.99.5]
synonym: "FAD-dependent sn-glycerol-3-phosphate dehydrogenase" NARROW [EC:1.1.99.5]
synonym: "FAD-linked glycerol 3-phosphate dehydrogenase" NARROW [EC:1.1.99.5]
synonym: "FAD-linked L-glycerol-3-phosphate dehydrogenase" NARROW [EC:1.1.99.5]
synonym: "flavin-linked glycerol-3-phosphate dehydrogenase" NARROW [EC:1.1.99.5]
synonym: "flavoprotein-linked L-glycerol 3-phosphate dehydrogenase" NARROW [EC:1.1.99.5]
synonym: "glycerol 3-phosphate cytochrome c reductase" NARROW [EC:1.1.99.5]
synonym: "glycerol phosphate dehydrogenase" EXACT [EC:1.1.99.5]
synonym: "glycerol phosphate dehydrogenase (acceptor)" EXACT [EC:1.1.99.5]
synonym: "glycerol phosphate dehydrogenase (FAD)" NARROW [EC:1.1.99.5]
synonym: "glycerol-3-phosphate dehydrogenase (flavin-linked)" NARROW [EC:1.1.99.5]
synonym: "glycerophosphate dehydrogenase" EXACT [EC:1.1.99.5]
synonym: "L-3-glycerophosphate-ubiquinone oxidoreductase" EXACT [EC:1.1.99.5]
synonym: "L-glycerol-3-phosphate dehydrogenase" EXACT [EC:1.1.99.5]
synonym: "NAD-independent glycerol phosphate dehydrogenase" NARROW [EC:1.1.99.5]
synonym: "pyridine nucleotide-independent L-glycerol 3-phosphate dehydrogenase" NARROW [EC:1.1.99.5]
synonym: "sn-glycerol 3-phosphate oxidase" EXACT [EC:1.1.99.5]
synonym: "sn-glycerol-3-phosphate dehydrogenase" EXACT [EC:1.1.99.5]
synonym: "sn-glycerol-3-phosphate:(acceptor) 2-oxidoreductase" EXACT [EC:1.1.99.5]
synonym: "sn-glycerol-3-phosphate:acceptor 2-oxidoreductase" EXACT [EC:1.1.99.5]
xref: EC:1.1.99.5
xref: MetaCyc:GLYC3PDEHYDROG-RXN
xref: MetaCyc:RXN-9927
xref: MetaCyc:RXN0-5258
xref: MetaCyc:RXN0-5260
xref: Reactome:10535 "glycerol-3-phosphate dehydrogenase activity"
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0004369
name: glycerol-3-phosphate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2." [EC:1.1.3.21]
subset: gosubset_prok
synonym: "alpha-glycerophosphate oxidase activity" EXACT [EC:1.1.3.21]
synonym: "glycerol phosphate oxidase activity" EXACT [EC:1.1.3.21]
synonym: "glycerol-1-phosphate oxidase activity" EXACT [EC:1.1.3.21]
synonym: "L-alpha-glycerol-3-phosphate oxidase activity" EXACT [EC:1.1.3.21]
synonym: "L-alpha-glycerophosphate oxidase activity" EXACT [EC:1.1.3.21]
synonym: "sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity" EXACT [EC:1.1.3.21]
xref: EC:1.1.3.21
xref: MetaCyc:GLYCEROL-3-PHOSPHATE-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0004370
name: glycerol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + glycerol = ADP + glycerol 3-phosphate." [EC:2.7.1.30]
subset: gosubset_prok
synonym: "ATP:glycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.30]
synonym: "ATP:glycerol-3-phosphotransferase activity" EXACT [EC:2.7.1.30]
synonym: "GK" RELATED [EC:2.7.1.30]
synonym: "glyceric kinase activity" EXACT [EC:2.7.1.30]
synonym: "glycerokinase activity" EXACT [EC:2.7.1.30]
synonym: "glycerol kinase (phosphorylating)" EXACT [EC:2.7.1.30]
xref: EC:2.7.1.30
xref: MetaCyc:GLYCEROL-KIN-RXN
xref: Reactome:10545 "glycerol kinase activity"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004371
name: glycerone kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate." [EC:2.7.1.29]
subset: gosubset_prok
synonym: "acetol kinase (phosphorylating)" EXACT [EC:2.7.1.29]
synonym: "acetol kinase activity" EXACT [EC:2.7.1.29]
synonym: "ATP:glycerone phosphotransferase activity" EXACT [EC:2.7.1.29]
synonym: "dihydroxyacetone kinase activity" EXACT [EC:2.7.1.29]
xref: EC:2.7.1.29
xref: MetaCyc:GLYCERONE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004372
name: glycine hydroxymethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1]
subset: gosubset_prok
synonym: "5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1]
synonym: "allothreonine aldolase activity" EXACT [EC:2.1.2.1]
synonym: "L-serine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1]
synonym: "serine aldolase activity" EXACT [EC:2.1.2.1]
synonym: "serine hydroxymethylase activity" EXACT [EC:2.1.2.1]
synonym: "serine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1]
synonym: "serine transhydroxymethylase activity" EXACT [EC:2.1.2.1]
xref: EC:2.1.2.1
xref: MetaCyc:GLYOHMETRANS-RXN
xref: Reactome:1060 "glycine hydroxymethyltransferase activity"
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0004373
name: glycogen (starch) synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.11]
subset: gosubset_prok
synonym: "glycogen (starch) synthetase activity" EXACT [EC:2.4.1.11]
synonym: "UDP-glucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11]
synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11]
synonym: "UDP-glycogen synthase activity" EXACT [EC:2.4.1.11]
synonym: "UDPG-glycogen synthetase activity" EXACT [EC:2.4.1.11]
synonym: "UDPG-glycogen transglucosylase activity" EXACT [EC:2.4.1.11]
synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11]
synonym: "uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11]
xref: EC:2.4.1.11
xref: MetaCyc:2.4.1.11-RXN
xref: Reactome:10552 "glycogen (starch) synthase activity"
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0004374
name: glycine cleavage system
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and glycine dehydrogenase (decarboxylating)." [EC:1.4.4.2, EC:2.1.2.10]
comment: This term was made obsolete because it represents a process rather than a function.
synonym: "glycine synthase" BROAD []
is_obsolete: true
replaced_by: GO:0019464

[Term]
id: GO:0004375
name: glycine dehydrogenase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2]
subset: gosubset_prok
synonym: "glycine cleavage system P-protein activity" NARROW [EC:1.4.4.2]
synonym: "glycine decarboxylase activity" EXACT [EC:1.4.4.2]
synonym: "glycine-cleavage complex" RELATED [EC:1.4.4.2]
synonym: "glycine-cleavage complex P-protein activity" EXACT [EC:1.4.4.2]
synonym: "glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)" EXACT [EC:1.4.4.2]
synonym: "glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)" EXACT [EC:1.4.4.2]
synonym: "P-protein" NARROW [EC:1.4.4.2]
synonym: "protein P1" NARROW [EC:1.4.4.2]
xref: EC:1.4.4.2
xref: MetaCyc:GCVP-RXN
is_a: GO:0016642 ! oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor

[Term]
id: GO:0004376
name: glycolipid mannosyltransferase activity
namespace: molecular_function
alt_id: GO:0004580
def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage." [GOC:ai]
synonym: "glycolipid mannosyl transferase activity" EXACT []
xref: EC:2.4.1.-
xref: Reactome:10559 "glycolipid mannosyltransferase activity"
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0004377
name: glycolipid 2-alpha-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,2-D-mannosyl-D-mannose linkage." [EC:2.4.1.131]
synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131]
synonym: "GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.131]
synonym: "guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131]
synonym: "oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131]
xref: EC:2.4.1.131
xref: MetaCyc:2.4.1.131-RXN
is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity
is_a: GO:0004376 ! glycolipid mannosyltransferase activity

[Term]
id: GO:0004378
name: glycolipid 3-alpha-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,3-D-mannosyl-D-mannose linkage." [EC:2.4.1.132]
synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase II" RELATED [EC:2.4.1.132]
synonym: "GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.132]
synonym: "guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity" EXACT [EC:2.4.1.132]
synonym: "mannosyltransferase II activity" EXACT [EC:2.4.1.132]
xref: EC:2.4.1.132
xref: MetaCyc:2.4.1.132-RXN
is_a: GO:0004376 ! glycolipid mannosyltransferase activity

[Term]
id: GO:0004379
name: glycylpeptide N-tetradecanoyltransferase activity
namespace: molecular_function
alt_id: GO:0019106
def: "Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97]
synonym: "myristoyl-CoA-protein N-myristoyltransferase activity" EXACT [EC:2.3.1.97]
synonym: "myristoyl-coenzyme A:protein N-myristoyl transferase activity" EXACT [EC:2.3.1.97]
synonym: "myristoylating enzymes" RELATED [EC:2.3.1.97]
synonym: "N-myristoyltransferase activity" EXACT []
synonym: "peptide N-myristoyltransferase activity" EXACT [EC:2.3.1.97]
synonym: "peptide N-tetradecanoyltransferase activity" EXACT [EC:2.3.1.97]
synonym: "protein N-myristoyltransferase activity" EXACT [EC:2.3.1.97]
synonym: "tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity" EXACT [EC:2.3.1.97]
xref: EC:2.3.1.97
xref: MetaCyc:2.3.1.97-RXN
is_a: GO:0016410 ! N-acyltransferase activity
is_a: GO:0019107 ! myristoyltransferase activity

[Term]
id: GO:0004380
name: glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.40]
synonym: "A transferase activity" RELATED [EC:2.4.1.40]
synonym: "A-transferase activity" EXACT [EC:2.4.1.40]
synonym: "alpha-3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40]
synonym: "blood-group substance A-dependent acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40]
synonym: "blood-group substance alpha-acetyltransferase activity" EXACT [EC:2.4.1.40]
synonym: "fucosylgalactose acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40]
synonym: "fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40]
synonym: "fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40]
synonym: "histo-blood group A acetylgalactosaminyltransferase activity" NARROW [EC:2.4.1.40]
synonym: "histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)" EXACT [EC:2.4.1.40]
synonym: "histo-blood group A transferase activity" RELATED [EC:2.4.1.40]
synonym: "UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40]
synonym: "UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.40]
synonym: "UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.40]
xref: EC:2.4.1.40
xref: MetaCyc:2.4.1.40-RXN
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0004381
name: fucosylgalactoside 3-alpha-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.37]
synonym: "[blood group substance] alpha-galactosyltransferase activity" NARROW [EC:2.4.1.37]
synonym: "B transferase activity" RELATED [EC:2.4.1.37]
synonym: "blood-group substance B-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37]
synonym: "blood-group substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37]
synonym: "fucosylglycoprotein 3-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.37]
synonym: "glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity" EXACT []
synonym: "histo-blood group B transferase activity" NARROW [EC:2.4.1.37]
synonym: "histo-blood substance B-dependent galactosyltransferase activity" EXACT [EC:2.4.1.37]
synonym: "histo-blood substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37]
synonym: "UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37]
synonym: "UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37]
synonym: "UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37]
synonym: "UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37]
xref: EC:2.4.1.37
xref: MetaCyc:2.4.1.37-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0004382
name: guanosine-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP + H2O = GMP + phosphate." [EC:3.6.1.42, PMID:2989286]
synonym: "GDP phosphohydrolase activity" EXACT [EC:3.6.1.42]
synonym: "GDPase activity" EXACT [EC:3.6.1.42]
synonym: "guanosine 5'-diphosphatase activity" EXACT [EC:3.6.1.6]
synonym: "guanosine diphosphatase activity" EXACT []
xref: EC:3.6.1.42
xref: MetaCyc:GUANOSINE-DIPHOSPHATASE-RXN
is_a: GO:0017110 ! nucleoside-diphosphatase activity

[Term]
id: GO:0004383
name: guanylate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
subset: gosubset_prok
synonym: "GTP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.2]
synonym: "GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity" EXACT [EC:4.6.1.2]
synonym: "guanyl cyclase activity" EXACT [EC:4.6.1.2]
synonym: "guanylyl cyclase activity" EXACT []
synonym: "receptor guanylate cyclase activity" NARROW []
xref: EC:4.6.1.2
xref: MetaCyc:GUANYLCYC-RXN
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0004384
name: membrane-associated guanylate kinase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane." [EC:2.7.4.8]
comment: This term was made obsolete because it represents a gene product and not a function.
synonym: "MAGUK" EXACT []
is_obsolete: true
consider: GO:0004385
consider: GO:0005102
consider: GO:0007155
consider: GO:0016021
consider: GO:0050839

[Term]
id: GO:0004385
name: guanylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8]
subset: gosubset_prok
synonym: "5'-GMP kinase activity" EXACT [EC:2.7.4.8]
synonym: "ATP:(d)GMP phosphotransferase activity" EXACT [EC:2.7.4.8]
synonym: "ATP:GMP phosphotransferase activity" EXACT [EC:2.7.4.8]
synonym: "deoxyguanylate kinase activity" RELATED [EC:2.7.4.8]
synonym: "GMP kinase activity" EXACT [EC:2.7.4.8]
synonym: "guanosine monophosphate kinase activity" EXACT [EC:2.7.4.8]
synonym: "membrane-associated guanylate kinase" NARROW []
xref: EC:2.7.4.8
xref: MetaCyc:GUANYL-KIN-RXN
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019201 ! nucleotide kinase activity

[Term]
id: GO:0004386
name: helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that most helicases catalyze processive duplex unwinding.
subset: goslim_candida
subset: goslim_goa
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Reactome:7001 "helicase activity"
is_a: GO:0017111 ! nucleoside-triphosphatase activity

[Term]
id: GO:0004392
name: heme oxygenase (decyclizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O." [EC:1.14.99.3]
synonym: "haem oxidase activity" EXACT [EC:1.14.99.3]
synonym: "haem oxygenase (decyclizing) activity" EXACT []
synonym: "haem oxygenase activity" EXACT [EC:1.14.99.3]
synonym: "heme oxidase activity" EXACT [EC:1.14.99.3]
synonym: "heme oxygenase activity" EXACT [EC:1.14.99.3]
synonym: "heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)" EXACT [EC:1.14.99.3]
synonym: "ORP33 proteins" RELATED [EC:1.14.99.3]
xref: EC:1.14.99.3
xref: MetaCyc:HEME-OXYGENASE-DECYCLIZING-RXN
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0004394
name: heparan sulfate 2-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate." [PMID:9153262]
synonym: "heparan-sulfate 2-O-sulphotransferase activity" EXACT []
synonym: "heparin 2-sulfotransferase activity" RELATED []
synonym: "heparin-sulphate 2-sulphotransferase activity" RELATED []
xref: EC:2.8.2.-
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0004395
name: hexaprenyldihydroxybenzoate methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate." [EC:2.1.1.114]
synonym: "3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase activity" EXACT [EC:2.1.1.114]
synonym: "DHHB methyltransferase activity" EXACT [EC:2.1.1.114]
synonym: "DHHB-Mt activity" EXACT [EC:2.1.1.114]
synonym: "dihydroxyhexaprenylbenzoate methyltransferase activity" EXACT [EC:2.1.1.114]
synonym: "S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase activity" EXACT [EC:2.1.1.114]
xref: EC:2.1.1.114
xref: MetaCyc:2.1.1.114-RXN
is_a: GO:0010420 ! polyprenyldihydroxybenzoate methyltransferase activity

[Term]
id: GO:0004396
name: hexokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate." [EC:2.7.1.1]
subset: gosubset_prok
synonym: "ATP-dependent hexokinase activity" EXACT [EC:2.7.1.1]
synonym: "ATP:D-hexose 6-phosphotransferase activity" EXACT [EC:2.7.1.1]
synonym: "glucose ATP phosphotransferase activity" EXACT [EC:2.7.1.1]
synonym: "hexokinase (phosphorylating)" EXACT [EC:2.7.1.1]
synonym: "hexokinase D" RELATED [EC:2.7.1.1]
synonym: "hexokinase type I activity" NARROW [EC:2.7.1.1]
synonym: "hexokinase type II activity" NARROW [EC:2.7.1.1]
synonym: "hexokinase type III activity" NARROW [EC:2.7.1.1]
synonym: "hexokinase type IV" RELATED [EC:2.7.1.1]
synonym: "hexokinase type IV (glucokinase) activity" NARROW [EC:2.7.1.1]
synonym: "hexokinase type IV glucokinase activity" EXACT [EC:2.7.1.1]
xref: EC:2.7.1.1
xref: MetaCyc:HEXOKINASE-RXN
xref: Reactome:10602 "hexokinase activity"
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0004397
name: histidine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidine = urocanate + NH3." [EC:4.3.1.3]
subset: gosubset_prok
synonym: "histidase activity" RELATED [GOC:hjd]
synonym: "histidinase activity" RELATED [GOC:hjd]
synonym: "histidine alpha-deaminase activity" RELATED [GOC:hjd]
synonym: "L-histidine ammonia-lyase (urocanate-forming)" EXACT [EC:4.3.1.3]
synonym: "L-histidine ammonia-lyase activity" EXACT [EC:4.3.1.3]
xref: EC:4.3.1.3
xref: MetaCyc:HISTIDINE-AMMONIA-LYASE-RXN
xref: Reactome:10604 "histidine ammonia-lyase activity"
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0004398
name: histidine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidine = histamine + CO2." [EC:4.1.1.22]
subset: gosubset_prok
synonym: "L-histidine carboxy-lyase (histamine-forming)" EXACT [EC:4.1.1.22]
synonym: "L-histidine carboxy-lyase activity" EXACT [EC:4.1.1.22]
synonym: "L-histidine decarboxylase activity" EXACT [EC:4.1.1.22]
xref: EC:4.1.1.22
xref: MetaCyc:HISTIDINE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004399
name: histidinol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+." [EC:1.1.1.23]
subset: gosubset_prok
xref: EC:1.1.1.23
xref: MetaCyc:HISTALDEHYD-RXN
xref: MetaCyc:HISTOLDEHYD-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004400
name: histidinol-phosphate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate." [EC:2.6.1.9]
subset: gosubset_prok
synonym: "glutamic-imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9]
synonym: "histidine:imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9]
synonym: "histidinol phosphate aminotransferase activity" EXACT [EC:2.6.1.9]
synonym: "histidinol-phosphate aminotransferase activity" EXACT []
synonym: "IAP transaminase activity" EXACT [EC:2.6.1.9]
synonym: "imidazole acetol-phosphate transaminase activity" EXACT [EC:2.6.1.9]
synonym: "imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9]
synonym: "imidazolylacetolphosphate aminotransferase activity" EXACT [EC:2.6.1.9]
synonym: "imidazolylacetolphosphate transaminase activity" EXACT [EC:2.6.1.9]
synonym: "L-histidinol phosphate aminotransferase activity" EXACT [EC:2.6.1.9]
synonym: "L-histidinol-phosphate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.9]
xref: EC:2.6.1.9
xref: MetaCyc:HISTAMINOTRANS-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004401
name: histidinol-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidinol-phosphate + H2O = L-histidinol + phosphate." [EC:3.1.3.15]
subset: gosubset_prok
synonym: "histidinol phosphate phosphatase activity" EXACT [EC:3.1.3.15]
synonym: "histidinolphosphatase activity" EXACT [EC:3.1.3.15]
synonym: "histidinolphosphate phosphatase activity" EXACT [EC:3.1.3.15]
synonym: "HPpase activity" EXACT [EC:3.1.3.15]
synonym: "L-histidinol phosphate phosphatase activity" EXACT [EC:3.1.3.15]
synonym: "L-histidinol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.15]
xref: EC:3.1.3.15
xref: MetaCyc:HISTIDPHOS-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0004402
name: histone acetyltransferase activity
namespace: molecular_function
alt_id: GO:0004403
alt_id: GO:0004404
alt_id: GO:0004405
alt_id: GO:0004406
alt_id: GO:0043166
alt_id: GO:0046971
def: "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48]
comment: Note that the term 'histone lysine acetyltransferase activity ; GO:0046971' was merged into this term because only lysine residues are ever acetylated in histones, and so the term was redundant.
synonym: "acetyl-CoA:histone acetyltransferase activity" EXACT [EC:2.3.1.48]
synonym: "H2A/H2B histone acetyltransferase activity" NARROW []
synonym: "H3/H4 histone acetyltransferase activity" NARROW []
synonym: "H4/H2 histone acetyltransferase activity" NARROW []
synonym: "H4/H2A acetyltransferase activity" NARROW []
synonym: "histone acetokinase activity" EXACT [EC:2.3.1.48]
synonym: "histone acetylase activity" EXACT []
synonym: "histone lysine acetyltransferase activity" EXACT []
synonym: "histone transacetylase activity" EXACT [EC:2.3.1.48]
synonym: "nucleosome-histone acetyltransferase activity" RELATED [EC:2.3.1.48]
xref: EC:2.3.1.48
xref: MetaCyc:HISTONE-ACETYLTRANSFERASE-RXN
is_a: GO:0004468 ! lysine N-acetyltransferase activity

[Term]
id: GO:0004407
name: histone deacetylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.-, http://cancerweb.ncl.ac.uk/]
xref: EC:3.5.1.-
xref: MetaCyc:3.5.1.98-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0033558 ! protein deacetylase activity

[Term]
id: GO:0004408
name: holocytochrome-c synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: holocytochrome c = apocytochrome c + heme." [EC:4.4.1.17]
subset: gosubset_prok
synonym: "cytochrome c heme-lyase activity" EXACT [EC:4.4.1.17]
synonym: "cytochrome c synthase activity" RELATED [EC:4.4.1.17]
synonym: "holocytochrome c synthetase activity" EXACT [EC:4.4.1.17]
synonym: "holocytochrome-c apocytochrome-c-lyase (heme-forming)" EXACT [EC:4.4.1.17]
synonym: "holocytochrome-c apocytochrome-c-lyase activity" EXACT [EC:4.4.1.17]
xref: EC:4.4.1.17
xref: MetaCyc:HOLOCYTOCHROME-C-SYNTHASE-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0004409
name: homoaconitate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxybutane-1,2,4-tricarboxylate = but-1-ene-1,2,4-tricarboxylate + H2O." [EC:4.2.1.36]
subset: gosubset_prok
synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.36]
synonym: "2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.36]
synonym: "cis-homoaconitase activity" EXACT [EC:4.2.1.36]
synonym: "HACN activity" EXACT [EC:4.2.1.36]
synonym: "homoaconitase activity" EXACT [EC:4.2.1.36]
synonym: "Lys4" RELATED [EC:4.2.1.36]
synonym: "LysF" RELATED [EC:4.2.1.36]
xref: EC:4.2.1.36
xref: MetaCyc:HOMOACONITATE-HYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004410
name: homocitrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + H2O + 2-oxoglutarate = 2-hydroxybutane-1,2,4-tricarboxylate + CoA." [EC:2.3.3.14]
comment: Note that this function was formerly EC:4.1.3.21.
subset: gosubset_prok
synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.14]
synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)" EXACT [EC:2.3.3.14]
synonym: "acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)" EXACT [EC:2.3.3.14]
synonym: "acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity" EXACT [EC:2.3.3.14]
synonym: "homocitrate synthetase activity" EXACT [EC:2.3.3.14]
xref: EC:2.3.3.14
xref: MetaCyc:HOMOCITRATE-SYNTHASE-RXN
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0004411
name: homogentisate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate." [EC:1.13.11.5]
subset: gosubset_prok
synonym: "homogentisate dioxygenase activity" EXACT [EC:1.13.11.5]
synonym: "homogentisate oxidase activity" EXACT [EC:1.13.11.5]
synonym: "homogentisate oxygenase activity" EXACT [EC:1.13.11.5]
synonym: "homogentisate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.5]
synonym: "homogentisic acid oxidase activity" EXACT [EC:1.13.11.5]
synonym: "homogentisic acid oxygenase activity" EXACT [EC:1.13.11.5]
synonym: "homogentisic oxygenase activity" EXACT [EC:1.13.11.5]
synonym: "homogentisicase activity" EXACT [EC:1.13.11.5]
xref: EC:1.13.11.5
xref: MetaCyc:HOMOGENTISATE-12-DIOXYGENASE-RXN
xref: Reactome:11355 "homogentisate 1,2-dioxygenase activity"
xref: UM-BBD_enzymeID:e0081
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0004412
name: homoserine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+." [EC:1.1.1.3]
subset: gosubset_prok
xref: EC:1.1.1.3
xref: MetaCyc:HOMOSERDEHYDROG-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004413
name: homoserine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine." [EC:2.7.1.39]
subset: gosubset_prok
synonym: "ATP:L-homoserine O-phosphotransferase activity" EXACT [EC:2.7.1.39]
synonym: "homoserine kinase (phosphorylating)" EXACT [EC:2.7.1.39]
synonym: "HSK" RELATED [EC:2.7.1.39]
xref: EC:2.7.1.39
xref: MetaCyc:HOMOSERKIN-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019202 ! amino acid kinase activity

[Term]
id: GO:0004414
name: homoserine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine." [EC:2.3.1.31]
subset: gosubset_prok
synonym: "acetyl-CoA:L-homoserine O-acetyltransferase activity" EXACT [EC:2.3.1.31]
synonym: "homoserine acetyltransferase activity" EXACT [EC:2.3.1.31]
synonym: "homoserine O-trans-acetylase activity" EXACT [EC:2.3.1.31]
synonym: "homoserine transacetylase activity" BROAD [EC:2.3.1.31]
synonym: "homoserine-O-transacetylase activity" EXACT [EC:2.3.1.31]
synonym: "L-homoserine O-acetyltransferase activity" EXACT [EC:2.3.1.31]
xref: EC:2.3.1.31
xref: MetaCyc:HOMOSERINE-O-ACETYLTRANSFERASE-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0004415
name: hyalurononglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate." [EC:3.2.1.35]
subset: gosubset_prok
synonym: "chondroitinase activity" BROAD [EC:3.2.1.35]
synonym: "chondroitinase I activity" EXACT [EC:3.2.1.35]
synonym: "hyaluronate 4-glycanohydrolase activity" EXACT [EC:3.2.1.35]
synonym: "hyaluronidase activity" BROAD [EC:3.2.1.35]
synonym: "hyaluronoglucosaminidase activity" EXACT []
synonym: "hyaluronoglucosidase activity" EXACT [EC:3.2.1.35]
xref: EC:3.2.1.35
xref: MetaCyc:3.2.1.35-RXN
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0004416
name: hydroxyacylglutathione hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate." [EC:3.1.2.6]
subset: gosubset_prok
synonym: "acetoacetylglutathione hydrolase activity" EXACT [EC:3.1.2.6]
synonym: "glyoxalase II activity" EXACT [EC:3.1.2.6]
synonym: "S-(2-hydroxyacyl)glutathione hydrolase activity" EXACT [EC:3.1.2.6]
synonym: "S-2-hydroxylacylglutathione hydrolase activity" EXACT [EC:3.1.2.6]
xref: EC:3.1.2.6
xref: MetaCyc:GLYOXII-RXN
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0004417
name: hydroxyethylthiazole kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 4-methyl-5-(2-hydroxyethyl)-thiazole = ADP + 4-methyl-5-(2-phosphoethyl)-thiazole." [EC:2.7.1.50]
subset: gosubset_prok
synonym: "4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity" EXACT [EC:2.7.1.50]
synonym: "ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity" EXACT [EC:2.7.1.50]
synonym: "hydroxyethylthiazole kinase (phosphorylating)" EXACT [EC:2.7.1.50]
xref: EC:2.7.1.50
xref: MetaCyc:THIAZOLSYN3-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004418
name: hydroxymethylbilane synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3." [EC:2.5.1.61]
comment: Note that this function was formerly EC:4.3.1.8.
subset: gosubset_prok
synonym: "(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity" EXACT [EC:2.5.1.61]
synonym: "(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61]
synonym: "HMB-synthase activity" EXACT [EC:2.5.1.61]
synonym: "porphobilinogen ammonia-lyase (polymerizing)" EXACT [EC:2.5.1.61]
synonym: "porphobilinogen deaminase activity" EXACT [EC:2.5.1.61]
synonym: "porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61]
synonym: "pre-uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61]
synonym: "uroporphyrinogen I synthase activity" NARROW [EC:2.5.1.61]
synonym: "uroporphyrinogen I synthetase activity" NARROW [EC:2.5.1.61]
synonym: "uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61]
synonym: "uroporphyrinogen synthetase activity" EXACT [EC:2.5.1.61]
xref: EC:2.5.1.61
xref: MetaCyc:OHMETHYLBILANESYN-RXN
xref: Reactome:11374 "hydroxymethylbilane synthase activity"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004419
name: hydroxymethylglutaryl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate." [EC:4.1.3.4]
subset: gosubset_prok
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.4]
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity" EXACT [EC:4.1.3.4]
synonym: "3-hydroxy-3-methylglutarate-CoA lyase activity" EXACT [EC:4.1.3.4]
synonym: "3-hydroxy-3-methylglutaryl CoA cleaving enzyme" RELATED [EC:4.1.3.4]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.4]
synonym: "3-hydroxy-3-methylglutaryl-CoA lyase activity" EXACT [EC:4.1.3.4]
synonym: "HMG-CoA lyase activity" EXACT [EC:4.1.3.4]
synonym: "hydroxymethylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.4]
synonym: "hydroxymethylglutaryl coenzyme A-cleaving enzyme" RELATED [EC:4.1.3.4]
xref: EC:4.1.3.4
xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN
xref: Reactome:74178 "hydroxymethylglutaryl-CoA lyase activity"
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0004420
name: hydroxymethylglutaryl-CoA reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+." [EC:1.1.1.34]
subset: gosubset_prok
synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.34]
synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.34]
xref: EC:1.1.1.34
xref: MetaCyc:1.1.1.34-RXN
xref: Reactome:11408 "hydroxymethylglutaryl-CoA reductase (NADPH) activity"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004421
name: hydroxymethylglutaryl-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA." [EC:2.3.3.10]
comment: Note that this function was formerly EC:4.1.3.5.
subset: gosubset_prok
synonym: "(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.10]
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)" EXACT [EC:2.3.3.10]
synonym: "3-hydroxy-3-methylglutaryl CoA synthetase activity" EXACT [EC:2.3.3.10]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthetase activity" EXACT [EC:2.3.3.10]
synonym: "3-hydroxy-3-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10]
synonym: "3-hydroxy-3-methylglutaryl-coenzyme A synthase activity" EXACT [EC:2.3.3.10]
synonym: "acetoacetyl coenzyme A transacetase activity" EXACT [EC:2.3.3.10]
synonym: "acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.10]
synonym: "beta-hydroxy-beta-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10]
synonym: "HMG-CoA synthase activity" EXACT [EC:2.3.3.10]
synonym: "hydroxymethylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10]
synonym: "hydroxymethylglutaryl coenzyme A-condensing enzyme" RELATED [EC:2.3.3.10]
synonym: "hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity" EXACT [EC:2.3.3.10]
xref: EC:2.3.3.10
xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
xref: Reactome:74169 "hydroxymethylglutaryl-CoA synthase activity"
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0004422
name: hypoxanthine phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate or GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators]
comment: Note that GO uses one molecular function term for consistency with Enzyme Nomenclature; also, all hypoxanthine phosphoribosyltransferases identified to date can act on either hypoxanthine or guanine, as well as xanthine or 6-mercaptopurine.
subset: gosubset_prok
synonym: "6-hydroxypurine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8]
synonym: "6-mercaptopurine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8]
synonym: "GMP pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "GPRT" RELATED [EC:2.4.2.8]
synonym: "guanine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8]
synonym: "guanine-hypoxanthine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8]
synonym: "guanosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "guanosine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8]
synonym: "guanylate pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "guanylic pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "HGPRTase activity" EXACT [EC:2.4.2.8]
synonym: "HPRT" RELATED [EC:2.4.2.8]
synonym: "hypoxanthine-guanine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8]
synonym: "IMP diphosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "IMP pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "IMP-GMP pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "IMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.8]
synonym: "inosinate pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "inosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "inosinic acid pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "inosinic pyrophosphorylase activity" EXACT [EC:2.4.2.8]
synonym: "purine-6-thiol phosphoribosyltransferase activity" EXACT [EC:2.4.2.8]
synonym: "Transphosphoribosidase activity" EXACT [EC:2.4.2.8]
xref: EC:2.4.2.8
xref: MetaCyc:HYPOXANPRIBOSYLTRAN-RXN
xref: Reactome:11410 "hypoxanthine phosphoribosyltransferase activity"
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004423
name: iduronate-2-sulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin." [EC:3.1.6.13]
subset: gosubset_prok
synonym: "2-sulfo-L-iduronate 2-sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.13]
synonym: "iduronate sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "iduronate sulfate sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "iduronate-2-sulfate sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "iduronate-2-sulphatase activity" EXACT []
synonym: "iduronide-2-sulfate sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "idurono-2-sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "L-iduronate 2-sulfate sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "L-iduronate-2-sulfate 2-sulfohydrolase activity" EXACT [EC:3.1.6.13]
synonym: "L-idurono sulfate sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "L-iduronosulfatase activity" EXACT [EC:3.1.6.13]
synonym: "sulfo-L-iduronate sulfatase activity" EXACT [EC:3.1.6.13]
synonym: "sulfoiduronate sulfohydrolase activity" EXACT [EC:3.1.6.13]
xref: EC:3.1.6.13
xref: MetaCyc:3.1.6.13-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0004424
name: imidazoleglycerol-phosphate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O." [EC:4.2.1.19]
subset: gosubset_prok
synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]" RELATED [EC:4.2.1.19]
synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity" EXACT [EC:4.2.1.19]
synonym: "IGP dehydratase activity" EXACT [EC:4.2.1.19]
synonym: "imidazoleglycerol phosphate dehydratase activity" EXACT []
xref: EC:4.2.1.19
xref: MetaCyc:IMIDPHOSDEHYD-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004425
name: indole-3-glycerol-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O." [EC:4.1.1.48]
subset: gosubset_prok
synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)" EXACT [EC:4.1.1.48]
synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]" RELATED [EC:4.1.1.48]
synonym: "indole-3-glycerophosphate synthase activity" EXACT [EC:4.1.1.48]
synonym: "indoleglycerol phosphate synthase activity" EXACT [EC:4.1.1.48]
synonym: "indoleglycerol phosphate synthetase activity" EXACT [EC:4.1.1.48]
xref: EC:4.1.1.48
xref: MetaCyc:IGPSYN-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004427
name: inorganic diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + H2O = 2 phosphate." [EC:3.6.1.1]
subset: gosubset_prok
synonym: "diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.1]
synonym: "inorganic pyrophosphatase activity" EXACT [EC:3.6.1.1]
synonym: "pyrophosphate phosphohydrolase activity" EXACT [EC:3.6.1.1]
xref: EC:3.6.1.1
xref: MetaCyc:INORGPYROPHOSPHAT-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0004428
name: inositol or phosphatidylinositol kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb]
subset: gosubset_prok
synonym: "inositol/phosphatidylinositol kinase activity" EXACT []
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0004430
name: 1-phosphatidylinositol 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate." [EC:2.7.1.67, PMID:9759495]
synonym: "ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase activity" EXACT [EC:2.7.1.67]
synonym: "phosphatidylinositol 4-kinase activity" BROAD [EC:2.7.1.67]
synonym: "phosphatidylinositol kinase (phosphorylating) activity" BROAD [EC:2.7.1.67]
synonym: "phosphatidylinositol kinase activity" BROAD [EC:2.7.1.67]
synonym: "PI 4-kinase activity" EXACT [EC:2.7.1.67]
synonym: "PI kinase activity" BROAD [EC:2.7.1.67]
synonym: "PI4-kinase activity" BROAD [EC:2.7.1.67]
synonym: "PI4K" BROAD [EC:2.7.1.67]
synonym: "PI4K-alpha activity" BROAD [EC:2.7.1.67]
synonym: "PtdIns-4-kinase activity" BROAD [EC:2.7.1.67]
synonym: "type II phosphatidylinositol kinase activity" RELATED [EC:2.7.1.67]
xref: EC:2.7.1.67
xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-KINASE-RXN
is_a: GO:0001727 ! lipid kinase activity
is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004432
name: 1-phosphatidylinositol-4-phosphate kinase, class IA
namespace: molecular_function
def: "OBSOLETE. A class I PI3K activated by tyrosine phosphorylation events." [PMID:11050418]
comment: This term was made obsolete because it is not a valid molecular function.
is_obsolete: true
consider: GO:0016308

[Term]
id: GO:0004433
name: 1-phosphatidylinositol-4-phosphate kinase, class IB
namespace: molecular_function
def: "OBSOLETE. A class I PI3K activated via heterotrimeric G-proteins." [PMID:11050418]
comment: This term was made obsolete because it is not a valid molecular function.
is_obsolete: true
consider: GO:0016308

[Term]
id: GO:0004434
name: inositol or phosphatidylinositol phosphodiesterase activity
namespace: molecular_function
subset: gosubset_prok
synonym: "inositol/phosphatidylinositol phosphodiesterase activity" EXACT []
xref: EC:3.1.4.-
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0004435
name: phosphoinositide phospholipase C activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." [EC:3.1.4.11]
subset: gosubset_prok
synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" EXACT [EC:3.1.4.11]
synonym: "1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" EXACT [EC:3.1.4.11]
synonym: "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity" EXACT []
synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:3.1.4.11]
synonym: "phosphatidylinositol phospholipase C activity" EXACT [EC:3.1.4.11]
synonym: "phosphatidylinositol-4,5-bisphosphate hydrolysis" RELATED []
synonym: "phosphoinositidase C activity" EXACT [EC:3.1.4.11]
synonym: "PI-PLC activity" EXACT [EC:3.1.4.11]
synonym: "triphosphoinositide phosphodiesterase activity" BROAD [EC:3.1.4.11]
xref: EC:3.1.4.11
xref: MetaCyc:3.1.4.11-RXN
xref: Reactome:11456 "phosphoinositide phospholipase C activity"
is_a: GO:0004434 ! inositol or phosphatidylinositol phosphodiesterase activity
is_a: GO:0004629 ! phospholipase C activity

[Term]
id: GO:0004436
name: phosphatidylinositol diacylglycerol-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol." [EC:4.6.1.13]
comment: Note that this function was formerly EC:3.1.4.10.
subset: gosubset_prok
synonym: "1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)" EXACT [EC:4.6.1.13]
synonym: "1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)" EXACT [EC:4.6.1.13]
synonym: "1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)" EXACT [EC:4.6.1.13]
synonym: "1-phosphatidylinositol phosphodiesterase activity" EXACT []
synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:4.6.1.13]
xref: EC:4.6.1.13
xref: MetaCyc:3.1.4.10-RXN
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0004437
name: inositol or phosphatidylinositol phosphatase activity
namespace: molecular_function
def: "Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb]
subset: gosubset_prok
synonym: "inositol/phosphatidylinositol phosphatase activity" EXACT []
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0004438
name: phosphatidylinositol-3-phosphatase activity
namespace: molecular_function
alt_id: GO:0016315
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64]
comment: Note that this function includes EC:3.1.3.65.
synonym: "1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64]
synonym: "D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64]
synonym: "inositol 1,3-bisphosphate phosphatase activity" EXACT [EC:3.1.3.64]
synonym: "inositol-1,3-bisphosphate 3-phosphatase activity" EXACT [EC:3.1.3.64]
synonym: "inositol-1,4,-bisphosphate 3-phosphatase activity" EXACT []
synonym: "inositol-polyphosphate 3-phosphatase activity" EXACT [EC:3.1.3.64]
synonym: "phosphatidyl-3-phosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64]
xref: EC:3.1.3.64
xref: MetaCyc:PHOSPHATIDYLINOSITOL-3-PHOSPHATASE-RXN
is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity
is_a: GO:0042577 ! lipid phosphatase activity

[Term]
id: GO:0004439
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
namespace: molecular_function
alt_id: GO:0001668
def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36]
synonym: "inositol 1,4,5-triphosphate 5-phosphomonoesterase activity" EXACT [EC:3.1.3.36]
synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity" EXACT [EC:3.1.3.36]
synonym: "phosphatidylinositol 4,5-bisphosphate phosphatase activity" BROAD [EC:3.1.3.36]
synonym: "phosphatidylinositol-bisphosphatase activity" BROAD [EC:3.1.3.36]
synonym: "PtdIns(4,5)P(2) phosphatase activity" EXACT [EC:3.1.3.36]
synonym: "PtdIns(4,5)P2 phosphatase activity" EXACT [EC:3.1.3.36]
synonym: "triphosphoinositide phosphatase activity" BROAD [EC:3.1.3.36]
synonym: "triphosphoinositide phosphomonoesterase activity" BROAD [EC:3.1.3.36]
xref: EC:3.1.3.36
xref: MetaCyc:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN
is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity
is_a: GO:0034595 ! phosphoinositide 5-phosphatase activity

[Term]
id: GO:0004441
name: inositol-1,4-bisphosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.57, GOC:hb]
synonym: "1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.57]
synonym: "inositol polyphosphate 1-phosphatase activity" BROAD [EC:3.1.3.57]
synonym: "inositol-polyphosphate 1-phosphatase activity" EXACT [EC:3.1.3.57]
xref: EC:3.1.3.57
xref: MetaCyc:3.1.3.57-RXN
is_a: GO:0016312 ! inositol bisphosphate phosphatase activity

[Term]
id: GO:0004442
name: inositol-1,4,-bisphosphate 3-phosphatase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate." [EC:3.1.3.65, GOC:go_curators]
is_obsolete: true
consider: GO:0004438

[Term]
id: GO:0004443
name: inositol-1,4,-bisphosphate 4-phosphatase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate." [EC:3.1.3.66, GOC:go_curators]
is_obsolete: true
consider: GO:0016316

[Term]
id: GO:0004444
name: inositol-1,4,5-trisphosphate 1-phosphatase
namespace: molecular_function
def: "OBSOLETE. The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate." [EC:3.1.3.61, GOC:hb]
comment: This term was made obsolete because the existence of this function has not been established.
is_obsolete: true
consider: GO:0046030

[Term]
id: GO:0004445
name: inositol-polyphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56]
synonym: "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.56]
synonym: "5PTase activity" RELATED [EC:3.1.3.56]
synonym: "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "inosine triphosphatase activity" RELATED [EC:3.1.3.56]
synonym: "inositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.56]
synonym: "inositol phosphate 5-phosphomonoesterase activity" BROAD [EC:3.1.3.56]
synonym: "inositol polyphosphate-5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "inositol triphosphate 5-phosphomonoesterase activity" EXACT []
synonym: "inositol trisphosphate phosphomonoesterase activity" BROAD [EC:3.1.3.56]
synonym: "inositol-1,4,5-trisphosphate 5-phosphatase activity" EXACT []
synonym: "inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "Ins(1,4,5)P(3) 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "Ins(1,4,5)P3 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "InsP3/Ins(1,3,4,5)P4 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity" BROAD [EC:3.1.3.56]
synonym: "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56]
synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56]
synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED []
synonym: "type II inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW []
xref: EC:3.1.3.56
xref: MetaCyc:3.1.3.56-RXN
is_a: GO:0046030 ! inositol trisphosphate phosphatase activity

[Term]
id: GO:0004446
name: multiple inositol-polyphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate." [EC:3.1.3.62]
synonym: "1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.62]
synonym: "inositol tetrakisphosphate phosphomonoesterase activity" EXACT [EC:3.1.3.62]
synonym: "MIPP activity" EXACT [EC:3.1.3.62]
xref: EC:3.1.3.62
xref: MetaCyc:RXN-7920
is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity

[Term]
id: GO:0004447
name: iodide peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: iodide + H2O2 = iodine + 2 H2O." [EC:1.11.1.8]
synonym: "iodide peroxidase-tyrosine iodinase activity" EXACT [EC:1.11.1.8]
synonym: "iodide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.8]
synonym: "iodinase activity" RELATED [EC:1.11.1.8]
synonym: "iodoperoxidase (heme type)" EXACT [EC:1.11.1.8]
synonym: "iodotyrosine deiodase activity" EXACT [EC:1.11.1.8]
synonym: "iodotyrosine deiodinase activity" EXACT [EC:1.11.1.8]
synonym: "monoiodotyrosine deiodinase activity" EXACT [EC:1.11.1.8]
synonym: "thyroid peroxidase activity" RELATED [EC:1.11.1.8]
synonym: "thyroperoxidase activity" RELATED [EC:1.11.1.8]
synonym: "TPO activity" RELATED [EC:1.11.1.8]
synonym: "tyrosine iodinase activity" EXACT [EC:1.11.1.8]
xref: EC:1.11.1.8
xref: MetaCyc:IODIDE-PEROXIDASE-RXN
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0004448
name: isocitrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor." [EC:1.1.1.41, EC:1.1.1.42]
subset: gosubset_prok
synonym: "beta-ketoglutaric-isocitric carboxylase activity" EXACT [EC:1.1.1.-]
synonym: "IDH activity" EXACT [EC:1.1.1.-]
synonym: "IDP activity" EXACT [EC:1.1.1.-]
synonym: "IDP1" RELATED [EC:1.1.1.-]
synonym: "IDP2" RELATED [EC:1.1.1.-]
synonym: "IDP3" RELATED [EC:1.1.1.-]
synonym: "isocitric acid dehydrogenase activity" EXACT [EC:1.1.1.-]
synonym: "isocitric dehydrogenase activity" EXACT [EC:1.1.1.-]
synonym: "oxalosuccinate carboxylase activity" EXACT [EC:1.1.1.-]
synonym: "oxalosuccinate decarboxylase activity" EXACT [EC:1.1.1.-]
synonym: "oxalsuccinic decarboxylase activity" EXACT [EC:1.1.1.-]
xref: EC:1.1.1.-
xref: MetaCyc:ISOCITDEH-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004449
name: isocitrate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+." [EC:1.1.1.41]
subset: gosubset_prok
synonym: "isocitrate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.41]
synonym: "isocitrate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.41]
synonym: "NAD dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41]
synonym: "NAD isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41]
synonym: "NAD isocitric dehydrogenase activity" EXACT [EC:1.1.1.41]
synonym: "NAD-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41]
synonym: "NAD-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41]
synonym: "nicotinamide adenine dinucleotide isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41]
xref: EC:1.1.1.41
xref: MetaCyc:ISOCITRATE-DEHYDROGENASE-NAD+-RXN
xref: Reactome:11496 "isocitrate dehydrogenase (NAD+) activity"
is_a: GO:0004448 ! isocitrate dehydrogenase activity

[Term]
id: GO:0004450
name: isocitrate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+." [EC:1.1.1.42]
subset: gosubset_prok
synonym: "dual-cofactor-specific isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42]
synonym: "isocitrate (NADP) dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "isocitrate dehydrogenase (NADP) activity" EXACT [EC:1.1.1.42]
synonym: "isocitrate dehydrogenase (NADP-dependent) activity" EXACT [EC:1.1.1.42]
synonym: "isocitrate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.42]
synonym: "NADP isocitric dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "NADP(+)-ICDH activity" EXACT [EC:1.1.1.42]
synonym: "NADP(+)-IDH activity" EXACT [EC:1.1.1.42]
synonym: "NADP(+)-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "NADP-dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "NADP-dependent isocitric dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "NADP-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "NADP-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42]
synonym: "triphosphopyridine nucleotide-linked isocitrate dehydrogenase- activity" RELATED [EC:1.1.1.42]
xref: EC:1.1.1.42
xref: MetaCyc:ISOCITDEH-RXN
xref: Reactome:11499 "isocitrate dehydrogenase (NADP+) activity"
is_a: GO:0004448 ! isocitrate dehydrogenase activity

[Term]
id: GO:0004451
name: isocitrate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: isocitrate = succinate + glyoxylate." [EC:4.1.3.1]
subset: gosubset_prok
synonym: "ICL activity" EXACT [EC:4.1.3.1]
synonym: "isocitrase activity" EXACT [EC:4.1.3.1]
synonym: "isocitratase activity" EXACT [EC:4.1.3.1]
synonym: "isocitrate glyoxylate-lyase (succinate-forming)" EXACT [EC:4.1.3.1]
synonym: "isocitrate glyoxylate-lyase activity" EXACT [EC:4.1.3.1]
synonym: "isocitritase activity" EXACT [EC:4.1.3.1]
synonym: "threo-DS-isocitrate glyoxylate-lyase activity" EXACT [EC:4.1.3.1]
xref: EC:4.1.3.1
xref: MetaCyc:ISOCIT-CLEAV-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0004452
name: isopentenyl-diphosphate delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the isomerization of isopentenyl diphosphate into dimethylallyl diphosphate." [EC:5.3.3.2]
subset: gosubset_prok
synonym: "IPP isomerase activity" EXACT [EC:5.3.3.2]
synonym: "ipp isomerase activity" EXACT [EC:5.3.3.2]
synonym: "isopentenyl-diphosphate D-isomerase activity" EXACT []
synonym: "isopentenyl-diphosphate delta3-delta2-isomerase activity" EXACT [EC:5.3.3.2]
synonym: "isopentenylpyrophosphate delta-isomerase activity" EXACT [EC:5.3.3.2]
synonym: "isopentenylpyrophosphate Delta-isomerase activity" EXACT [EC:5.3.3.2]
synonym: "isopentenylpyrophosphate isomerase activity" EXACT [EC:5.3.3.2]
synonym: "methylbutenylpyrophosphate isomerase activity" EXACT [EC:5.3.3.2]
xref: EC:5.3.3.2
xref: MetaCyc:IPPISOM-RXN
xref: Reactome:11501 "isopentenyl-diphosphate delta-isomerase activity"
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0004453
name: juvenile-hormone esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone." [EC:3.1.1.59, EMBL:AF304352]
synonym: "JH esterase activity" EXACT [EC:3.1.1.59]
synonym: "JH-esterase activity" EXACT [EC:3.1.1.59]
synonym: "juvenile hormone analog esterase activity" EXACT [EC:3.1.1.59]
synonym: "juvenile hormone carboxyesterase activity" EXACT [EC:3.1.1.59]
synonym: "methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity" EXACT [EC:3.1.1.59]
xref: EC:3.1.1.59
xref: MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0004454
name: ketohexokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate." [EC:2.7.1.3]
subset: gosubset_prok
synonym: "ATP:D-fructose 1-phosphotransferase activity" EXACT [EC:2.7.1.3]
synonym: "hepatic fructokinase activity" NARROW [EC:2.7.1.3]
synonym: "ketohexokinase (phosphorylating)" EXACT [EC:2.7.1.3]
xref: EC:2.7.1.3
xref: MetaCyc:KETOHEXOKINASE-RXN
xref: Reactome:11506 "ketohexokinase activity"
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0004455
name: ketol-acid reductoisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+." [EC:1.1.1.86]
subset: gosubset_prok
synonym: "(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)" EXACT [EC:1.1.1.86]
synonym: "2-hydroxy-3-keto acid reductoisomerase activity" EXACT [EC:1.1.1.86]
synonym: "acetohydroxy acid isomeroreductase activity" EXACT [EC:1.1.1.86]
synonym: "acetohydroxy acid reductoisomerase activity" EXACT [EC:1.1.1.86]
synonym: "acetolactate reductoisomerase activity" EXACT [EC:1.1.1.86]
synonym: "alpha-keto-beta-hydroxylacyl reductoisomerase activity" EXACT [EC:1.1.1.86]
synonym: "dihydroxyisovalerate (isomerizing) dehydrogenase activity" EXACT [EC:1.1.1.86]
synonym: "dihydroxyisovalerate dehydrogenase (isomerizing) activity" EXACT [EC:1.1.1.86]
synonym: "isomeroreductase activity" EXACT [EC:1.1.1.86]
synonym: "ketol acid reductoisomerase activity" EXACT [EC:1.1.1.86]
synonym: "reductoisomerase activity" EXACT [EC:1.1.1.86]
xref: EC:1.1.1.86
xref: MetaCyc:ACETOLACTREDUCTOISOM-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004456
name: phosphogluconate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O." [EC:4.2.1.12]
subset: gosubset_prok
synonym: "6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)" EXACT [EC:4.2.1.12]
synonym: "6-phospho-D-gluconate hydro-lyase activity" EXACT [EC:4.2.1.12]
synonym: "6-phosphogluconate dehydrase activity" EXACT [EC:4.2.1.12]
synonym: "6-phosphogluconate dehydratase activity" EXACT [EC:4.2.1.12]
synonym: "6-phosphogluconic dehydrase activity" EXACT [EC:4.2.1.12]
synonym: "gluconate 6-phosphate dehydratase activity" EXACT [EC:4.2.1.12]
synonym: "gluconate-6-phosphate dehydratase activity" EXACT [EC:4.2.1.12]
xref: EC:4.2.1.12
xref: MetaCyc:PGLUCONDEHYDRAT-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004457
name: lactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the oxidation of lactate to produce pyruvate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0004458
name: D-lactate dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.4]
subset: gosubset_prok
synonym: "(R)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.4]
synonym: "cytochrome-dependent D-(-)-lactate dehydrogenase activity" EXACT [EC:1.1.2.4]
synonym: "D-(-)-lactic cytochrome c reductase activity" EXACT [EC:1.1.2.4]
synonym: "D-lactate (cytochrome) dehydrogenase activity" EXACT [EC:1.1.2.4]
synonym: "D-lactate ferricytochrome c oxidoreductase activity" EXACT [EC:1.1.2.4]
synonym: "D-lactate-cytochrome c reductase activity" EXACT [EC:1.1.2.4]
synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.4]
xref: EC:1.1.2.4
xref: MetaCyc:D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN
is_a: GO:0004457 ! lactate dehydrogenase activity
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0004459
name: L-lactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.27]
subset: gosubset_prok
synonym: "L-lactic acid dehydrogenase activity" EXACT [EC:1.1.1.27]
synonym: "L-lactic dehydrogenase activity" EXACT [EC:1.1.1.27]
xref: EC:1.1.1.27
xref: MetaCyc:L-LACTATE-DEHYDROGENASE-RXN
xref: Reactome:11515 "L-lactate dehydrogenase activity"
is_a: GO:0004457 ! lactate dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004460
name: L-lactate dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.3]
subset: gosubset_prok
synonym: "(S)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.3]
synonym: "cytochrome b2" RELATED []
synonym: "cytochrome b2 (flavin-free derivative of flavocytochrome b2)" RELATED [EC:1.1.2.3]
synonym: "dehydrogenase, lactate (cytochrome)" EXACT [EC:1.1.2.3]
synonym: "flavocytochrome b2" RELATED [EC:1.1.2.3]
synonym: "L(+)-lactate:cytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3]
synonym: "L-lactate cytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3]
synonym: "L-lactate cytochrome c reductase activity" EXACT [EC:1.1.2.3]
synonym: "L-lactate ferricytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3]
synonym: "lactate dehydrogenase (cytochrome)" EXACT [EC:1.1.2.3]
synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.3]
synonym: "lactic cytochrome c reductase activity" EXACT [EC:1.1.2.3]
xref: EC:1.1.2.3
xref: MetaCyc:L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN
is_a: GO:0004457 ! lactate dehydrogenase activity
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0004461
name: lactose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose." [EC:2.4.1.22]
synonym: "lactose synthetase activity" EXACT [EC:2.4.1.22]
synonym: "UDP-galactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22]
synonym: "UDP-galactose:D-glucose 4-beta-D-galactotransferase activity" EXACT [EC:2.4.1.22]
synonym: "UDPgalactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22]
synonym: "UDPgalactose:D-glucose 4-beta-D-galactotransferase activity" EXACT [EC:2.4.1.22]
synonym: "uridine diphosphogalactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22]
xref: EC:2.4.1.22
xref: MetaCyc:LACTOSE-SYNTHASE-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0004462
name: lactoylglutathione lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5]
subset: gosubset_prok
synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity" EXACT [EC:4.4.1.5]
synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)" EXACT [EC:4.4.1.5]
synonym: "aldoketomutase activity" EXACT [EC:4.4.1.5]
synonym: "glyoxalase I activity" EXACT [EC:4.4.1.5]
synonym: "glyoxylase I" RELATED [EC:4.4.1.5]
synonym: "ketone-aldehyde mutase activity" EXACT [EC:4.4.1.5]
synonym: "methylglyoxalase activity" EXACT [EC:4.4.1.5]
xref: EC:4.4.1.5
xref: MetaCyc:GLYOXI-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0004463
name: leukotriene-A4 hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate." [EC:3.3.2.6]
subset: gosubset_prok
synonym: "(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity" EXACT [EC:3.3.2.6]
synonym: "leukotriene A(4) hydrolase activity" EXACT [EC:3.3.2.6]
synonym: "leukotriene A4 hydrolase activity" EXACT [EC:3.3.2.6]
synonym: "LTA-4 hydrolase activity" EXACT [EC:3.3.2.6]
synonym: "LTA4 hydrolase activity" EXACT [EC:3.3.2.6]
synonym: "LTA4H" RELATED [EC:3.3.2.6]
xref: EC:3.3.2.6
xref: MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN
xref: Reactome:1463 "leukotriene-A4 hydrolase activity"
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0004464
name: leukotriene-C4 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: leukotriene C4 = leukotriene A4 + glutathione." [EC:2.5.1.37]
comment: Note that this function was EC:2.5.1.37.
synonym: "(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)" EXACT [EC:4.4.1.20]
synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)" EXACT [EC:4.4.1.20]
synonym: "leukotriene A(4):glutathione S-leukotrienyltransferase activity" EXACT [EC:4.4.1.20]
synonym: "leukotriene A4:glutathione S-leukotrienyltransferase activity" EXACT [EC:4.4.1.20]
synonym: "leukotriene C(4) synthetase activity" EXACT [EC:4.4.1.20]
synonym: "leukotriene C4 synthetase activity" EXACT [EC:4.4.1.20]
synonym: "leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)" EXACT [EC:4.4.1.20]
synonym: "LTC(4) synthase activity" EXACT [EC:4.4.1.20]
synonym: "LTC(4) synthetase activity" EXACT [EC:4.4.1.20]
synonym: "LTC4 synthase activity" EXACT [EC:4.4.1.20]
synonym: "LTC4 synthetase activity" EXACT [EC:4.4.1.20]
xref: EC:4.4.1.20
xref: MetaCyc:LEUKOTRIENE-C4-SYNTHASE-RXN
xref: Reactome:11538 "leukotriene-C4 synthase activity"
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0004465
name: lipoprotein lipase activity
namespace: molecular_function
def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.34]
synonym: "clearing factor lipase activity" RELATED [EC:3.1.1.34]
synonym: "diacylglycerol hydrolase activity" EXACT [EC:3.1.1.34]
synonym: "diacylglycerol lipase activity" EXACT [EC:3.1.1.34]
synonym: "diglyceride lipase activity" EXACT [EC:3.1.1.34]
synonym: "lipemia-clearing factor" RELATED [EC:3.1.1.34]
synonym: "postheparin esterase activity" EXACT [EC:3.1.1.34]
synonym: "postheparin lipase activity" EXACT [EC:3.1.1.34]
synonym: "triacylglycero-protein acylhydrolase activity" EXACT [EC:3.1.1.34]
xref: EC:3.1.1.34
xref: MetaCyc:LIPOPROTEIN-LIPASE-RXN
xref: Reactome:11541 "lipoprotein lipase activity"
is_a: GO:0004091 ! carboxylesterase activity
is_a: GO:0016298 ! lipase activity

[Term]
id: GO:0004466
name: long-chain-acyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF." [EC:1.3.99.13]
subset: gosubset_prok
synonym: "long-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.13]
synonym: "long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.13]
synonym: "long-chain-acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.13]
synonym: "palmitoyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.13]
synonym: "palmitoyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.13]
xref: EC:1.3.99.13
xref: MetaCyc:LONG-CHAIN-ACYL-COA-DEHYDROGENASE-RXN
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0004467
name: long-chain-fatty-acid-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18." [EC:6.2.1.3]
subset: gosubset_prok
synonym: "ACS3" NARROW [EC:6.2.1.3]
synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.3]
synonym: "acyl-CoA synthetase activity" EXACT [EC:6.2.1.3]
synonym: "arachidonyl-CoA synthetase" NARROW [EC:6.2.1.3]
synonym: "FAA1" NARROW [EC:6.2.1.3]
synonym: "fatty acid thiokinase (long chain) activity" EXACT [EC:6.2.1.3]
synonym: "fatty acid thiokinase (long-chain) activity" EXACT [EC:6.2.1.3]
synonym: "LCFA synthetase activity" EXACT [EC:6.2.1.3]
synonym: "lignoceroyl-CoA synthase activity" EXACT [EC:6.2.1.3]
synonym: "long chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.3]
synonym: "long-chain acyl CoA synthetase activity" EXACT [EC:6.2.1.3]
synonym: "long-chain acyl-CoA synthetase activity" EXACT []
synonym: "long-chain acyl-CoA synthetase I" NARROW [EC:6.2.1.3]
synonym: "long-chain acyl-CoA synthetase II" NARROW [EC:6.2.1.3]
synonym: "long-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3]
synonym: "long-chain fatty acid activation" RELATED []
synonym: "long-chain fatty acid-CoA ligase activity" EXACT []
synonym: "long-chain fatty acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3]
synonym: "long-chain-fatty-acyl-CoA synthetase activity" EXACT []
synonym: "oleoyl-CoA synthetase" NARROW [EC:6.2.1.3]
synonym: "palmitoyl coenzyme A synthetase" NARROW [EC:6.2.1.3]
synonym: "palmitoyl-CoA ligase" NARROW [EC:6.2.1.3]
synonym: "palmitoyl-CoA synthase" NARROW [EC:6.2.1.3]
synonym: "pristanoyl-CoA synthetase" NARROW [EC:6.2.1.3]
synonym: "stearoyl-CoA synthetase" NARROW [EC:6.2.1.3]
synonym: "thiokinase" RELATED [EC:6.2.1.3]
xref: EC:6.2.1.3
xref: MetaCyc:ACYLCOASYN-RXN
xref: MetaCyc:PWY-5143
xref: Reactome:11544 "long-chain-fatty-acid-CoA ligase activity"
xref: UM-BBD_enzymeID:e0025
is_a: GO:0015645 ! fatty-acid ligase activity

[Term]
id: GO:0004468
name: lysine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine." [EC:2.3.1.32]
subset: gosubset_prok
synonym: "acetyl-phosphate:L-lysine 6-N-acetyltransferase activity" EXACT [EC:2.3.1.32]
synonym: "acetyl-phosphate:L-lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.32]
synonym: "LAT activity" EXACT [EC:2.3.1.32]
synonym: "lysine acetyltransferase activity" EXACT []
synonym: "lysine N(6)-acetyltransferase activity" EXACT [EC:2.3.1.32]
synonym: "lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.32]
xref: EC:2.3.1.32
xref: MetaCyc:LYSINE-N-ACETYLTRANSFERASE-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0004470
name: malic enzyme activity
namespace: molecular_function
def: "Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyruvic-malic carboxylase activity" EXACT [EC:1.1.1.39]
xref: MetaCyc:1.1.1.39-RXN
xref: MetaCyc:MALIC-NAD-RXN
xref: MetaCyc:MALIC-NADP-RXN
is_a: GO:0016615 ! malate dehydrogenase activity

[Term]
id: GO:0004471
name: malate dehydrogenase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Does not decarboxylate oxaloacetate." [EC:1.1.1.39]
subset: gosubset_prok
synonym: "'malic' enzyme" RELATED [EC:1.1.1.39]
synonym: "(S)-malate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.39]
synonym: "NAD-malic enzyme activity" BROAD [EC:1.1.1.39]
synonym: "NAD-specific malic enzyme" RELATED [EC:1.1.1.39]
xref: EC:1.1.1.39
xref: MetaCyc:1.1.1.39-RXN
is_a: GO:0004470 ! malic enzyme activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004473
name: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate." [EC:1.1.1.40]
subset: gosubset_prok
synonym: "'malic' enzyme" RELATED [EC:1.1.1.40]
synonym: "(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [EC:1.1.1.40]
synonym: "L-malate:NADP oxidoreductase activity" EXACT [EC:1.1.1.40]
synonym: "malate dehydrogenase (decarboxylating, NADP)" EXACT [EC:1.1.1.40]
synonym: "malate dehydrogenase (NADP, decarboxylating)" EXACT [EC:1.1.1.40]
synonym: "NADP-linked decarboxylating malic enzyme" RELATED [EC:1.1.1.40]
synonym: "NADP-malic enzyme activity" EXACT [EC:1.1.1.40]
synonym: "NADP-specific malate dehydrogenase activity" EXACT [EC:1.1.1.40]
synonym: "NADP-specific malic enzyme" RELATED [EC:1.1.1.40]
xref: EC:1.1.1.40
xref: MetaCyc:MALIC-NADP-RXN
is_a: GO:0004470 ! malic enzyme activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004474
name: malate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + H2O + glyoxylate = L-malate + CoA." [EC:2.3.3.9]
comment: Note that this function was formerly EC:4.1.3.2.
subset: gosubset_prok
synonym: "acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.9]
synonym: "glyoxylate transacetase activity" EXACT [EC:2.3.3.9]
synonym: "glyoxylate transacetylase activity" EXACT [EC:2.3.3.9]
synonym: "glyoxylic transacetase activity" EXACT [EC:2.3.3.9]
synonym: "L-malate glyoxylate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.9]
synonym: "malate condensing enzyme activity" RELATED [EC:2.3.3.9]
synonym: "malate synthetase activity" EXACT [EC:2.3.3.9]
synonym: "malic synthetase activity" EXACT [EC:2.3.3.9]
synonym: "malic-condensing enzyme activity" RELATED [EC:2.3.3.9]
xref: EC:2.3.3.9
xref: MetaCyc:MALSYN-RXN
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0004475
name: mannose-1-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose." [EC:2.7.7.13]
subset: gosubset_prok
synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.13]
synonym: "GTP-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13]
synonym: "GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13]
synonym: "GTP:mannose-1-phosphate guanylyltransferase activity" EXACT []
synonym: "guanosine 5'-diphospho-D-mannose pyrophosphorylase activity" EXACT [EC:2.7.7.13]
synonym: "guanosine diphosphomannose pyrophosphorylase activity" EXACT [EC:2.7.7.13]
synonym: "guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13]
synonym: "mannose 1-phosphate guanylyltransferase (guanosine triphosphate)" EXACT [EC:2.7.7.13]
synonym: "PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)" RELATED [EC:2.7.7.13]
xref: EC:2.7.7.13
xref: MetaCyc:2.7.7.13-RXN
is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity

[Term]
id: GO:0004476
name: mannose-6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.8]
subset: gosubset_prok
synonym: "D-mannose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.8]
synonym: "D-mannose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.8]
synonym: "mannose phosphate isomerase activity" EXACT [EC:5.3.1.8]
synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.8]
synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.8]
synonym: "phosphomannoisomerase activity" EXACT [EC:5.3.1.8]
synonym: "phosphomannose isomerase activity" EXACT [EC:5.3.1.8]
xref: EC:5.3.1.8
xref: MetaCyc:MANNPISOM-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004477
name: methenyltetrahydrofolate cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate." [EC:3.5.4.9]
subset: gosubset_prok
synonym: "5,10-methenyl-THF cyclohydrolase activity" EXACT [GOC:vw]
synonym: "5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)" EXACT [EC:3.5.4.9]
synonym: "citrovorum factor cyclodehydrase activity" EXACT [EC:3.5.4.9]
synonym: "formyl-methenyl-methylenetetrahydrofolate synthetase (combined)" EXACT [EC:3.5.4.9]
xref: EC:3.5.4.9
xref: MetaCyc:METHENYLTHFCYCLOHYDRO-RXN
xref: Reactome:11565 "methenyltetrahydrofolate cyclohydrolase activity"
is_a: GO:0019238 ! cyclohydrolase activity

[Term]
id: GO:0004478
name: methionine adenosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine." [EC:2.5.1.6]
subset: gosubset_prok
synonym: "adenosylmethionine synthetase activity" EXACT [EC:2.5.1.6]
synonym: "AdoMet synthetase activity" EXACT [EC:2.5.1.6]
synonym: "ATP-methionine adenosyltransferase activity" EXACT [EC:2.5.1.6]
synonym: "ATP:L-methionine S-adenosyltransferase activity" EXACT [EC:2.5.1.6]
synonym: "methionine S-adenosyltransferase activity" EXACT [EC:2.5.1.6]
synonym: "methionine-activating enzyme" RELATED [EC:2.5.1.6]
synonym: "S-adenosyl-L-methionine synthetase activity" EXACT [EC:2.5.1.6]
synonym: "S-adenosylmethionine synthase activity" EXACT [EC:2.5.1.6]
synonym: "S-adenosylmethionine synthetase activity" EXACT [EC:2.5.1.6]
xref: EC:2.5.1.6
xref: MetaCyc:S-ADENMETSYN-RXN
xref: Reactome:11567 "methionine adenosyltransferase activity"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004479
name: methionyl-tRNA formyltransferase activity
namespace: molecular_function
alt_id: GO:0001718
alt_id: GO:0070128
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA." [EC:2.1.2.9]
subset: gosubset_prok
synonym: "10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity" EXACT [EC:2.1.2.9]
synonym: "conversion of met-tRNAf to fmet-tRNA" RELATED [GO:curators]
synonym: "conversion of mitochondrial met-tRNAf to fmet-tRNA" RELATED [GO:curators]
synonym: "formylmethionyl-transfer ribonucleic synthetase activity" EXACT [EC:2.1.2.9]
synonym: "methionyl ribonucleic formyltransferase activity" EXACT [EC:2.1.2.9]
synonym: "methionyl-transfer ribonucleate methyltransferase activity" RELATED [EC:2.1.2.9]
synonym: "methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9]
synonym: "methionyl-transfer RNA transformylase activity" EXACT [EC:2.1.2.9]
synonym: "methionyl-tRNA Met formyltransferase activity" EXACT [EC:2.1.2.9]
synonym: "methionyl-tRNA transformylase activity" EXACT [EC:2.1.2.9]
synonym: "mitochondrial N-terminal peptidyl-methionine N-formylation" RELATED [GO:curators]
synonym: "N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9]
synonym: "N-terminal peptidyl-methionine N-formylation" RELATED [GO:curators]
synonym: "N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9]
xref: EC:2.1.2.9
xref: MetaCyc:METHIONYL-TRNA-FORMYLTRANSFERASE-RXN
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0004481
name: methylene-fatty-acyl-phospholipid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid." [EC:2.1.1.16]
synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.16]
synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)" EXACT [EC:2.1.1.16]
synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.16]
xref: EC:2.1.1.16
xref: MetaCyc:2.1.1.16-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004482
name: mRNA (guanine-N7-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA; m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine." [EC:2.1.1.56]
synonym: "guanine-7-methyltransferase activity" EXACT [EC:2.1.1.56]
synonym: "messenger ribonucleate guanine 7-methyltransferase activity" EXACT [EC:2.1.1.56]
synonym: "messenger RNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.56]
synonym: "S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity" EXACT [EC:2.1.1.56]
synonym: "S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity" EXACT [EC:2.1.1.56]
xref: EC:2.1.1.56
xref: MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN
xref: Reactome:72079 "mRNA (guanine-N7-)-methyltransferase activity"
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008174 ! mRNA methyltransferase activity

[Term]
id: GO:0004483
name: mRNA (nucleoside-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine." [EC:2.1.1.57]
subset: gosubset_prok
synonym: "messenger ribonucleate nucleoside 2'-methyltransferase activity" EXACT [EC:2.1.1.57]
synonym: "messenger RNA (nucleoside-2'-)-methyltransferase activity" EXACT [EC:2.1.1.57]
synonym: "mRNA (adenosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57]
synonym: "S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57]
xref: EC:2.1.1.57
xref: MetaCyc:2.1.1.57-RXN
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008174 ! mRNA methyltransferase activity

[Term]
id: GO:0004484
name: mRNA guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50]
synonym: "GTP--RNA guanylyltransferase activity" EXACT [EC:2.7.7.50]
synonym: "GTP:mRNA guanylyltransferase activity" EXACT []
synonym: "messenger RNA guanylyltransferase activity" EXACT [EC:2.7.7.50]
synonym: "mRNA capping enzyme activity" RELATED [EC:2.7.7.50]
synonym: "protein lambda2" RELATED [EC:2.7.7.50]
xref: EC:2.7.7.50
xref: MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN
xref: Reactome:80327 "mRNA guanylyltransferase activity"
is_a: GO:0008192 ! RNA guanylyltransferase activity

[Term]
id: GO:0004485
name: methylcrotonoyl-CoA carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 3-methylcrotonyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA." [EC:6.4.1.4]
subset: gosubset_prok
synonym: "3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.4]
synonym: "beta-methylcrotonyl CoA carboxylase activity" EXACT [EC:6.4.1.4]
synonym: "beta-methylcrotonyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.4]
synonym: "beta-methylcrotonyl-CoA carboxylase activity" EXACT [EC:6.4.1.4]
synonym: "methylcrotonyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.4]
synonym: "methylcrotonyl-CoA carboxylase activity" EXACT [EC:6.4.1.4]
xref: EC:6.4.1.4
xref: MetaCyc:METHYLCROTONYL-COA-CARBOXYLASE-RXN
xref: Reactome:11585 "methylcrotonoyl-CoA carboxylase activity"
is_a: GO:0016421 ! CoA carboxylase activity

[Term]
id: GO:0004486
name: methylenetetrahydrofolate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.-, EC:1.5.1.15]
subset: gosubset_prok
synonym: "5,10-methylene-THF dehydrogenase activity" EXACT [GOC:vw]
synonym: "N5,N10-methylenetetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.5]
xref: EC:1.5.1.-
xref: Reactome:11590 "methylenetetrahydrofolate dehydrogenase activity"
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004487
name: methylenetetrahydrofolate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH + H+." [EC:1.5.1.15]
synonym: "5,10-methylenetetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.5]
synonym: "5,10-methylenetetrahydrofolate:NAD+ oxidoreductase" EXACT [EC:1.5.1.15]
xref: EC:1.5.1.15
xref: MetaCyc:1.5.1.15-RXN
is_a: GO:0004486 ! methylenetetrahydrofolate dehydrogenase activity

[Term]
id: GO:0004488
name: methylenetetrahydrofolate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+." [EC:1.5.1.5]
subset: gosubset_prok
synonym: "5,10-methylenetetrahydrofolate:NADP oxidoreductase activity" EXACT [EC:1.5.1.5]
synonym: "5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.5]
xref: EC:1.5.1.5
xref: MetaCyc:METHYLENETHFDEHYDROG-NADP-RXN
is_a: GO:0004486 ! methylenetetrahydrofolate dehydrogenase activity

[Term]
id: GO:0004489
name: methylenetetrahydrofolate reductase (NADPH) activity
namespace: molecular_function
alt_id: GO:0008702
def: "Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.20]
comment: Includes EC 1.7.99.5.
subset: gosubset_prok
synonym: "1.7.99.5" RELATED []
synonym: "5,10-CH(2)-H(4)folate reductase activity" EXACT [EC:1.5.1.20]
synonym: "5,10-CH2-H4folate reductase activity" EXACT [EC:1.5.1.20]
synonym: "5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [EC:1.5.1.20]
synonym: "5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT []
synonym: "5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT []
synonym: "5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [EC:1.5.1.20]
synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20]
synonym: "5,10-methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20]
synonym: "5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [EC:1.5.1.20]
synonym: "5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.20]
synonym: "MetF" RELATED [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate reductase (NADPH2)" EXACT [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [EC:1.5.1.20]
synonym: "methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20]
synonym: "methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20]
synonym: "MTHFR activity" BROAD [EC:1.5.1.20]
synonym: "N(5),N(10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20]
synonym: "N(5,10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20]
synonym: "N5,10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20]
synonym: "N5,N10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20]
xref: EC:1.5.1.20
xref: MetaCyc:1.5.1.20-RXN
xref: Reactome:11594 "methylenetetrahydrofolate reductase (NADPH) activity"
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004490
name: methylglutaconyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O." [EC:4.2.1.18]
subset: gosubset_prok
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)" EXACT [EC:4.2.1.18]
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity" EXACT [EC:4.2.1.18]
synonym: "3-methylglutaconyl CoA hydratase activity" EXACT [EC:4.2.1.18]
synonym: "methylglutaconase activity" EXACT [EC:4.2.1.18]
synonym: "methylglutaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.18]
xref: EC:4.2.1.18
xref: MetaCyc:METHYLGLUTACONYL-COA-HYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004491
name: methylmalonate-semialdehyde dehydrogenase (acylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+." [EC:1.2.1.27]
subset: gosubset_prok
synonym: "2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)" EXACT [EC:1.2.1.27]
synonym: "MMSA dehydrogenase activity" EXACT [EC:1.2.1.27]
synonym: "MSDH activity" EXACT [EC:1.2.1.27]
xref: EC:1.2.1.27
xref: MetaCyc:1.2.1.27-RXN
xref: Reactome:70889 "methylmalonate-semialdehyde dehydrogenase (acylating) activity"
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004492
name: methylmalonyl-CoA decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2." [EC:4.1.1.41]
subset: gosubset_prok
synonym: "(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.41]
synonym: "(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)" EXACT [EC:4.1.1.41]
synonym: "(S)-methylmalonyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.41]
synonym: "methylmalonyl-coenzyme A decarboxylase activity" EXACT [EC:4.1.1.41]
xref: EC:4.1.1.41
xref: MetaCyc:METHYLMALONYL-COA-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004493
name: methylmalonyl-CoA epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-methyl-3-oxopropanoyl-CoA = (S)-2-methyl-3-oxopropanoyl-CoA." [EC:5.1.99.1]
subset: gosubset_prok
synonym: "2-methyl-3-oxopropanoyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.1]
synonym: "DL-methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1]
synonym: "dl-methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1]
synonym: "methylmalonyl coenzyme A racemase activity" EXACT [EC:5.1.99.1]
synonym: "methylmalonyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.1]
synonym: "methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1]
xref: EC:5.1.99.1
xref: MetaCyc:METHYLMALONYL-COA-EPIM-RXN
xref: Reactome:11610 "methylmalonyl-CoA epimerase activity"
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0004494
name: methylmalonyl-CoA mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-methyl-3-oxopropanoyl-CoA = succinyl-CoA." [EC:5.4.99.2]
subset: gosubset_prok
synonym: "(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.2]
synonym: "(R)-methylmalonyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.2]
synonym: "(S)-methylmalonyl-CoA mutase activity" EXACT [EC:5.4.99.2]
synonym: "methylmalonyl coenzyme A carbonylmutase activity" EXACT [EC:5.4.99.2]
synonym: "methylmalonyl coenzyme A mutase activity" EXACT [EC:5.4.99.2]
synonym: "methylmalonyl-CoA CoA-carbonyl mutase activity" EXACT [EC:5.4.99.2]
xref: EC:5.4.99.2
xref: MetaCyc:METHYLMALONYL-COA-MUT-RXN
xref: Reactome:11612 "methylmalonyl-CoA mutase activity"
xref: UM-BBD_enzymeID:e0575
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0004495
name: mevaldate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor." [EC:1.1.1.32, EC:1.1.1.33]
xref: EC:1.1.1.-
xref: MetaCyc:MEVALDATE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004496
name: mevalonate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate." [EC:2.7.1.36]
subset: gosubset_prok
synonym: "ATP:(R)-mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36]
synonym: "ATP:mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36]
synonym: "mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36]
synonym: "mevalonate kinase (phosphorylating)" EXACT [EC:2.7.1.36]
synonym: "mevalonate phosphokinase activity" EXACT [EC:2.7.1.36]
synonym: "mevalonic acid kinase activity" EXACT [EC:2.7.1.36]
synonym: "mevalonic kinase activity" EXACT [EC:2.7.1.36]
synonym: "MVA kinase activity" EXACT [EC:2.7.1.36]
xref: EC:2.7.1.36
xref: MetaCyc:MEVALONATE-KINASE-RXN
xref: Reactome:11620 "mevalonate kinase activity"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004497
name: monooxygenase activity
namespace: molecular_function
def: "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
synonym: "hydroxylase activity" RELATED [GOC:mah, GOC:vk]
xref: Reactome:9021 "monooxygenase activity"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0004498
name: calcidiol 1-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [EC:1.14.13.13]
synonym: "1-hydroxylase-25-hydroxyvitamin D3" RELATED [EC:1.14.13.13]
synonym: "25-hydroxy D3-1alpha-hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "25-hydroxy vitamin D3 1-alpha-hydroxylase activity" EXACT []
synonym: "25-hydroxycholecalciferol 1-hydroxylase activity" EXACT []
synonym: "25-hydroxycholecalciferol 1-monooxygenase activity" EXACT [EC:1.14.13.13]
synonym: "25-hydroxycholecalciferol 1alpha-hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "25-hydroxycholecalciferol-1-hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "25-hydroxyvitamin D-1 alpha hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "25-hydroxyvitamin D3 1alpha-hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "25-OHD-1 alpha-hydroxylase activity" EXACT [EC:1.14.13.13]
synonym: "calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)" EXACT [EC:1.14.13.13]
synonym: "cytochrome P450 CYP27B" NARROW []
xref: EC:1.14.13.13
xref: MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN
xref: Reactome:11623 "calcidiol 1-monooxygenase activity"
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004499
name: flavin-containing monooxygenase activity
namespace: molecular_function
alt_id: GO:0047076
def: "Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8]
subset: gosubset_prok
synonym: "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity" EXACT [EC:1.13.12.11]
synonym: "dimethylaniline monooxygenase (N-oxide-forming) activity" EXACT []
synonym: "dimethylaniline N-oxidase activity" EXACT [EC:1.13.12.11]
synonym: "dimethylaniline oxidase activity" EXACT [EC:1.13.12.11]
synonym: "DMA oxidase activity" EXACT [EC:1.13.12.11]
synonym: "FAD-containing monooxygenase activity" RELATED [EC:1.13.12.11]
synonym: "flavin mixed function oxidase activity" RELATED [EC:1.13.12.11]
synonym: "flavin monooxygenase activity" RELATED [EC:1.13.12.11]
synonym: "FMO activity" RELATED [EC:1.13.12.11]
synonym: "FMO-I" RELATED [EC:1.13.12.11]
synonym: "FMO-II" RELATED [EC:1.13.12.11]
synonym: "FMO1" RELATED [EC:1.13.12.11]
synonym: "FMO2" RELATED [EC:1.13.12.11]
synonym: "FMO3" RELATED [EC:1.13.12.11]
synonym: "FMO4" RELATED [EC:1.13.12.11]
synonym: "FMO5" RELATED [EC:1.13.12.11]
synonym: "methylphenyltetrahydropyridine N-monooxygenase activity" EXACT []
synonym: "mixed-function amine oxidase activity" RELATED [EC:1.13.12.11]
synonym: "N,N-dimethylaniline monooxygenase activity" EXACT [EC:1.13.12.11]
synonym: "N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)" EXACT [EC:1.13.12.11]
synonym: "Ziegler's enzyme" RELATED [EC:1.13.12.11]
xref: EC:1.14.13.8
xref: MetaCyc:1.14.13.8-RXN
xref: Reactome:11625 "flavin-containing monooxygenase activity"
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004500
name: dopamine beta-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O." [EC:1.14.17.1]
subset: gosubset_prok
synonym: "(3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity" EXACT [EC:1.14.17.1]
synonym: "3,4-dihydroxyphenethylamine beta-oxidase activity" EXACT [EC:1.14.17.1]
synonym: "3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)" EXACT [EC:1.14.17.1]
synonym: "4-(2-aminoethyl)pyrocatechol beta-oxidase activity" EXACT [EC:1.14.17.1]
synonym: "dopa beta-hydroxylase activity" EXACT [EC:1.14.17.1]
synonym: "dopamine b-hydroxylase activity" EXACT []
synonym: "dopamine beta-hydroxylase activity" EXACT [EC:1.14.17.1]
synonym: "dopamine beta-oxidase activity" EXACT [EC:1.14.17.1]
synonym: "dopamine hydroxylase activity" EXACT [EC:1.14.17.1]
synonym: "dopamine-B-hydroxylase activity" EXACT [EC:1.14.17.1]
synonym: "MDBH (membrane-associated dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1]
synonym: "oxygenase, dopamine beta-mono-" EXACT [EC:1.14.17.1]
synonym: "phenylamine beta-hydroxylase activity" EXACT [EC:1.14.17.1]
synonym: "SDBH (soluble dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1]
xref: EC:1.14.17.1
xref: MetaCyc:DOPAMINE-BETA-MONOOXYGENASE-RXN
xref: Reactome:12238 "dopamine beta-monooxygenase activity"
is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004501
name: ecdysone 20-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: ecdysone + donor-H2 + O2 = 20-hydroxyecdysone + acceptor + H2O." [EC:1.14.99.22]
synonym: "alpha-ecdysone C-20 hydroxylase activity" EXACT [EC:1.14.99.22]
synonym: "ecdysone 20-hydroxylase activity" EXACT []
synonym: "ecdysone modification" BROAD []
synonym: "ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.99.22]
xref: EC:1.14.99.22
xref: MetaCyc:ECDYSONE-20-MONOOXYGENASE-RXN
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0004502
name: kynurenine 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O." [EC:1.14.13.9]
subset: gosubset_prok
synonym: "kynurenine 3-hydroxylase activity" EXACT []
synonym: "kynurenine hydroxylase activity" EXACT [EC:1.14.13.9]
synonym: "L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.9]
synonym: "L-kynurenine-3-hydroxylase activity" EXACT [EC:1.14.13.9]
xref: EC:1.14.13.9
xref: MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN
xref: Reactome:12242 "kynurenine 3-monooxygenase activity"
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004503
name: monophenol monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [EC:1.14.18.1]
subset: gosubset_prok
synonym: "catecholase" BROAD [EC:1.14.18.1]
synonym: "chlorogenic acid oxidase activity" EXACT [EC:1.14.18.1]
synonym: "chlorogenic oxidase activity" EXACT [EC:1.14.18.1]
synonym: "cresolase activity" EXACT [EC:1.14.18.1]
synonym: "dopa oxidase" BROAD [EC:1.14.18.1]
synonym: "monophenol dihydroxyphenylalanine:oxygen oxidoreductase activity" EXACT [EC:1.14.18.1]
synonym: "monophenol monooxidase activity" EXACT [EC:1.14.18.1]
synonym: "monophenol oxidase activity" EXACT [EC:1.14.18.1]
synonym: "monophenol oxygenase" EXACT [PMID:2494997]
synonym: "monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase activity" EXACT [EC:1.14.18.1]
synonym: "monophenol,L-dopa:oxygen oxidoreductase activity" EXACT [EC:1.14.18.1]
synonym: "monophenolase activity" EXACT [EC:1.14.18.1]
synonym: "N-acetyl-6-hydroxytryptophan oxidase activity" EXACT [EC:1.14.18.1]
synonym: "o-diphenol oxidase activity" EXACT [EC:1.14.18.1]
synonym: "o-diphenol oxidoreductase" BROAD [EC:1.14.18.1]
synonym: "o-diphenol:O2 oxidoreductase activity" EXACT [EC:1.14.18.1]
synonym: "o-diphenol:oxygen oxidoreductase" BROAD [EC:1.14.18.1]
synonym: "phenol oxidase activity" EXACT []
synonym: "phenolase activity" BROAD [EC:1.14.18.1]
synonym: "polyaromatic oxidase activity" EXACT [EC:1.14.18.1]
synonym: "polyphenolase activity" EXACT [EC:1.14.18.1]
synonym: "prophenol oxidase" RELATED []
synonym: "pyrocatechol oxidase" BROAD [EC:1.14.18.1]
synonym: "tyrosinase activity" BROAD [EC:1.14.18.1]
synonym: "tyrosine-dopa oxidase activity" EXACT [EC:1.14.18.1]
xref: EC:1.14.18.1
xref: MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN
is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004504
name: peptidylglycine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O." [EC:1.14.17.3]
subset: gosubset_prok
synonym: "PAM activity" EXACT [EC:1.14.17.3]
synonym: "PAM-A" RELATED [EC:1.14.17.3]
synonym: "PAM-B" RELATED [EC:1.14.17.3]
synonym: "peptide alpha-amidating enzyme" RELATED [EC:1.14.17.3]
synonym: "peptide alpha-amide synthase activity" EXACT [EC:1.14.17.3]
synonym: "peptide-alpha-amide synthetase activity" EXACT [EC:1.14.17.3]
synonym: "peptidyl alpha-amidating enzyme activity" EXACT [EC:1.14.17.3]
synonym: "peptidylglycine 2-hydroxylase activity" EXACT []
synonym: "peptidylglycine alpha-amidating monooxygenase activity" EXACT [EC:1.14.17.3]
synonym: "peptidylglycine alpha-hydroxylase activity" EXACT [EC:1.14.17.3]
synonym: "peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.17.3]
synonym: "synthase, peptide alpha-amide" EXACT [EC:1.14.17.3]
xref: EC:1.14.17.3
xref: MetaCyc:PEPTIDYLGLYCINE-MONOOXYGENASE-RXN
is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004505
name: phenylalanine 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin." [EC:1.14.16.1]
subset: gosubset_prok
synonym: "L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.16.1]
synonym: "PAH activity" EXACT [EC:1.14.16.1]
synonym: "phenylalaninase activity" EXACT [EC:1.14.16.1]
synonym: "phenylalanine 4-hydroxylase activity" EXACT [EC:1.14.16.1]
synonym: "phenylalanine hydroxylase activity" EXACT []
xref: EC:1.14.16.1
xref: MetaCyc:PHENYLALANINE-4-MONOOXYGENASE-RXN
xref: Reactome:12249 "phenylalanine 4-monooxygenase activity"
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004506
name: squalene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the formation of a 2,3-epoxide in squalene." [EC:1.14.99.7]
synonym: "squalene 2,3-oxidocyclase activity" EXACT [EC:1.14.99.7]
synonym: "squalene epoxidase activity" EXACT [EC:1.14.99.7]
synonym: "squalene hydroxylase activity" EXACT []
synonym: "squalene oxydocyclase activity" EXACT [EC:1.14.99.7]
synonym: "squalene,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)" EXACT [EC:1.14.99.7]
synonym: "squalene-2,3-epoxidase activity" EXACT [EC:1.14.99.7]
synonym: "squalene-2,3-epoxide cyclase activity" EXACT [EC:1.14.99.7]
xref: EC:1.14.99.7
xref: MetaCyc:SQUALENE-MONOOXYGENASE-RXN
xref: Reactome:12251 "squalene monooxygenase activity"
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0004507
name: steroid 11-beta-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.4]
synonym: "cytochrome P450 CYP11B1" NARROW []
synonym: "cytochrome P450 CYP11B2" NARROW []
synonym: "cytochrome p450 XIB1 activity" NARROW [EC:1.14.15.4]
synonym: "oxygenase, steroid 11beta -mono-" EXACT [EC:1.14.15.4]
synonym: "steroid 11-beta-hydroxylase activity" EXACT []
synonym: "steroid 11-beta/18-hydroxylase activity" EXACT [EC:1.14.15.4]
synonym: "steroid 11beta-hydroxylase activity" EXACT [EC:1.14.15.4]
synonym: "steroid 11beta-monooxygenase activity" EXACT [EC:1.14.15.4]
synonym: "steroid 11beta/18-hydroxylase activity" EXACT [EC:1.14.15.4]
synonym: "steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)" EXACT [EC:1.14.15.4]
xref: EC:1.14.15.4
xref: MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN
xref: Reactome:12257 "steroid 11-beta-monooxygenase activity"
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004508
name: steroid 17-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O." [EC:1.14.99.9]
synonym: "17alpha-hydroxylase-C17,20 lyase activity" EXACT [EC:1.14.99.9]
synonym: "cytochrome P-450 (P-45017alpha,lyase)" RELATED [EC:1.14.99.9]
synonym: "cytochrome P450 CYP17" NARROW []
synonym: "cytochrome p450 XVIIA1 activity" NARROW [EC:1.14.99.9]
synonym: "cytochrome P45017alpha" RELATED [EC:1.14.99.9]
synonym: "steroid 17-alpha-hydroxylase activity" EXACT []
synonym: "steroid 17-alpha-hydroxylase-C17-20 lyase activity" EXACT []
synonym: "steroid 17-alpha-hydroxylase/17,20 lyase activity" EXACT [EC:1.14.99.9]
synonym: "steroid 17alpha-hydroxylase activity" EXACT [EC:1.14.99.9]
synonym: "steroid 17alpha-monooxygenase activity" EXACT [EC:1.14.99.9]
synonym: "steroid 17alphahydroxylase/17,20 lyase activity" EXACT [EC:1.14.99.9]
synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)" EXACT [EC:1.14.99.9]
xref: EC:1.14.99.9
xref: MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN
xref: Reactome:12260 "steroid 17-alpha-monooxygenase activity"
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0004509
name: steroid 21-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O." [EC:1.14.99.10]
synonym: "21-hydroxylase activity" EXACT [EC:1.14.99.10]
synonym: "cytochrome P450 CYP21A1" NARROW []
synonym: "cytochrome p450 XXIA1 activity" NARROW [EC:1.14.99.10]
synonym: "steroid 21-hydroxylase activity" EXACT []
synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)" EXACT [EC:1.14.99.10]
xref: EC:1.14.99.10
xref: MetaCyc:STEROID-21-MONOOXYGENASE-RXN
xref: Reactome:12262 "steroid 21-monooxygenase activity"
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0004510
name: tryptophan 5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.4]
synonym: "indoleacetic acid-5-hydroxylase activity" EXACT [EC:1.14.16.4]
synonym: "L-tryptophan hydroxylase activity" EXACT []
synonym: "L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.16.4]
synonym: "tryptophan 5-hydroxylase activity" EXACT [EC:1.14.16.4]
synonym: "tryptophan hydroxylase activity" EXACT [EC:1.14.16.4]
xref: EC:1.14.16.4
xref: MetaCyc:TRYPTOPHAN-5-MONOOXYGENASE-RXN
xref: Reactome:12281 "tryptophan 5-monooxygenase activity"
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004511
name: tyrosine 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.2]
synonym: "L-tyrosine hydroxylase activity" EXACT [EC:1.14.16.2]
synonym: "L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.16.2]
synonym: "tyrosine 3-hydroxylase activity" EXACT []
synonym: "tyrosine hydroxylase activity" EXACT []
xref: EC:1.14.16.2
xref: MetaCyc:TYROSINE-3-MONOOXYGENASE-RXN
xref: Reactome:12282 "tyrosine 3-monooxygenase activity"
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004512
name: inositol-3-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate; requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form." [EC:5.5.1.4]
subset: gosubset_prok
synonym: "1L-myo-inositol-1-phosphate lyase (isomerizing)" EXACT [EC:5.5.1.4]
synonym: "D-glucose 6-phosphate cycloaldolase activity" EXACT [EC:5.5.1.4]
synonym: "glucocycloaldolase activity" EXACT [EC:5.5.1.4]
synonym: "glucose 6-phosphate cyclase activity" EXACT [EC:5.5.1.4]
synonym: "glucose-6-phosphate inositol monophosphate cycloaldolase activity" EXACT [EC:5.5.1.4]
synonym: "inositol 1-phosphate synthatase activity" EXACT [EC:5.5.1.4]
synonym: "inositol 1-phosphate synthetase activity" EXACT [EC:5.5.1.4]
synonym: "myo-inositol-1-phosphate synthase activity" EXACT []
xref: EC:5.5.1.4
xref: MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0004513
name: neolactotetraosylceramide alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide." [EC:2.4.99.10]
synonym: "CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.10]
synonym: "cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase activity" EXACT [EC:2.4.99.10]
synonym: "SAT-3" RELATED [EC:2.4.99.10]
synonym: "sialyltransferase 3" RELATED [EC:2.4.99.10]
xref: EC:2.4.99.10
xref: MetaCyc:2.4.99.10-RXN
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0004514
name: nicotinate-nucleotide diphosphorylase (carboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.19]
subset: gosubset_prok
synonym: "NAD pyrophosphorylase activity" EXACT [EC:2.4.2.19]
synonym: "nicotinate mononucleotide pyrophosphorylase (carboxylating)" EXACT [EC:2.4.2.19]
synonym: "nicotinate-nucleotide pyrophosphorylase (carboxylating) activity" EXACT []
synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)" EXACT [EC:2.4.2.19]
synonym: "QAPRTase activity" EXACT [EC:2.4.2.19]
synonym: "quinolinate phosphoribosyltransferase (decarboxylating) activity" EXACT [EC:2.4.2.19]
synonym: "quinolinic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.19]
synonym: "quinolinic phosphoribosyltransferase activity" EXACT [EC:2.4.2.19]
xref: EC:2.4.2.19
xref: MetaCyc:QUINOPRIBOTRANS-RXN
xref: Reactome:12286 "nicotinate-nucleotide diphosphorylase (carboxylating) activity"
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004515
name: nicotinate-nucleotide adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+." [EC:2.7.7.18]
subset: gosubset_prok
synonym: "ATP:nicotinate-nucleotide adenylyltransferase activity" EXACT []
synonym: "ATP:nicotinate-ribonucleotide adenylyltransferase activity" EXACT [EC:2.7.7.18]
synonym: "deamido-NAD(+) diphosphorylase activity" EXACT [EC:2.7.7.18]
synonym: "deamido-NAD(+) pyrophosphorylase activity" EXACT [EC:2.7.7.18]
synonym: "deamido-NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.18]
synonym: "deamidonicotinamide adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.18]
synonym: "NaMN-ATase activity" EXACT [EC:2.7.7.18]
synonym: "nicotinate mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.18]
synonym: "nicotinic acid mononucleotide adenylyltransferase" NARROW []
xref: EC:2.7.7.18
xref: MetaCyc:NICONUCADENYLYLTRAN-RXN
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0004516
name: nicotinate phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.11]
subset: gosubset_prok
synonym: "niacin ribonucleotidase activity" EXACT [EC:2.4.2.11]
synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.11]
synonym: "nicotinic acid mononucleotide glycohydrolase activity" EXACT [EC:2.4.2.11]
synonym: "nicotinic acid mononucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.11]
synonym: "nicotinic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.11]
xref: EC:2.4.2.11
xref: MetaCyc:NICOTINATEPRIBOSYLTRANS-RXN
xref: Reactome:12293 "nicotinate phosphoribosyltransferase activity"
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004517
name: nitric-oxide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39]
subset: gosubset_prok
synonym: "endothelium-derived relaxation factor-forming enzyme activity" RELATED [EC:1.14.13.39]
synonym: "endothelium-derived relaxing factor synthase activity" RELATED [EC:1.14.13.39]
synonym: "L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity" EXACT [EC:1.14.13.39]
synonym: "NADPH-diaphorase activity" EXACT [EC:1.14.13.39]
synonym: "nitric oxide synthase activity" EXACT []
synonym: "nitric oxide synthetase activity" EXACT [EC:1.14.13.39]
synonym: "nitric-oxide synthetase activity" EXACT [EC:1.14.13.39]
synonym: "NO synthase activity" EXACT [EC:1.14.13.39]
xref: EC:1.14.13.39
xref: MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN
xref: Reactome:12296 "nitric-oxide synthase activity"
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0004518
name: nuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684]
comment: Consider also annotating to the molecular function term 'nucleic acid binding ; GO:0003676'. Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis.
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
xref: EC:3.1.-.-
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0004519
name: endonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
xref: Reactome:3138 "endonuclease activity"
is_a: GO:0004518 ! nuclease activity

[Term]
id: GO:0004520
name: endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "DNA nicking activity" RELATED [GOC:mah]
synonym: "endonuclease G activity" NARROW []
xref: Reactome:3136 "endodeoxyribonuclease activity"
is_a: GO:0004519 ! endonuclease activity
is_a: GO:0004536 ! deoxyribonuclease activity

[Term]
id: GO:0004521
name: endoribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "endonuclease G activity" NARROW []
is_a: GO:0004519 ! endonuclease activity
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0004522
name: pancreatic ribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.5]
synonym: "alkaline ribonuclease activity" EXACT [EC:3.1.27.5]
synonym: "ceratitis capitata alkaline ribonuclease activity" EXACT [EC:3.1.27.5]
synonym: "endoribonuclease I" RELATED [EC:3.1.27.5]
synonym: "gene S glycoproteins" RELATED [EC:3.1.27.5]
synonym: "gene S locus-specific glycoproteins" RELATED [EC:3.1.27.5]
synonym: "pancreatic RNase activity" EXACT [EC:3.1.27.5]
synonym: "ribonuclease A" EXACT []
synonym: "ribonuclease I activity" EXACT [EC:3.1.27.5]
synonym: "ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity" EXACT [EC:3.1.27.5]
synonym: "ribonucleic phosphatase activity" EXACT [EC:3.1.27.5]
synonym: "RNase A activity" EXACT [EC:3.1.27.5]
synonym: "RNase activity" BROAD [EC:3.1.27.5]
synonym: "RNase I activity" EXACT [EC:3.1.27.5]
synonym: "S-genotype-assocd. glycoproteins" RELATED [EC:3.1.27.5]
synonym: "SLSG glycoproteins" RELATED [EC:3.1.27.5]
xref: EC:3.1.27.5
xref: MetaCyc:3.1.27.5-RXN
xref: Wikipedia:Ribonuclease_A
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0004523
name: ribonuclease H activity
namespace: molecular_function
alt_id: GO:0004524
def: "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]
comment: Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species.
subset: gosubset_prok
synonym: "calf thymus ribonuclease H activity" EXACT []
synonym: "endoribonuclease H" RELATED [EC:3.1.26.4]
synonym: "endoribonuclease H (calf thymus)" RELATED [EC:3.1.26.4]
synonym: "endoribonuclease0 H activity" NARROW [EC:3.1.26.4]
synonym: "hybrid nuclease activity" EXACT [EC:3.1.26.4]
synonym: "hybrid ribonuclease activity" EXACT [EC:3.1.26.4]
synonym: "hybridase (ribonuclease H)" EXACT [EC:3.1.26.4]
synonym: "hybridase activity" EXACT [EC:3.1.26.4]
synonym: "ribonuclease H1 activity" NARROW []
synonym: "ribonuclease H2 activity" NARROW []
synonym: "ribonuclease H3 activity" NARROW []
synonym: "RNA*DNA hybrid ribonucleotidohydrolase activity" EXACT [EC:3.1.26.4]
synonym: "RNase H activity" EXACT []
synonym: "RNase H1 activity" NARROW []
synonym: "RNase H2 activity" NARROW []
synonym: "RNase H3 activity" NARROW []
xref: EC:3.1.26.4
xref: MetaCyc:3.1.26.4-RXN
xref: Reactome:12321 "ribonuclease H activity"
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0004525
name: ribonuclease III activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]
subset: gosubset_prok
synonym: "pre-mRNA 3'-end processing endonuclease" NARROW []
synonym: "ribonuclease 3 activity" EXACT [EC:3.1.26.3]
synonym: "RNase III activity" EXACT [EC:3.1.26.3]
xref: EC:3.1.26.3
xref: MetaCyc:3.1.26.3-RXN
xref: Reactome:12326 "ribonuclease III activity"
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0004526
name: ribonuclease P activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5]
subset: gosubset_prok
synonym: "RNase P" EXACT []
synonym: "tRNA 5' leader endonuclease activity" EXACT []
xref: EC:3.1.26.5
xref: MetaCyc:3.1.26.5-RXN
xref: Wikipedia:RNase_P
is_a: GO:0004549 ! tRNA-specific ribonuclease activity
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0004527
name: exonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0004518 ! nuclease activity

[Term]
id: GO:0004528
name: phosphodiesterase I activity
namespace: molecular_function
def: "Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides." [EC:3.1.4.1]
subset: gosubset_prok
synonym: "5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [EC:3.1.4.1]
synonym: "5'-exonuclease activity" RELATED [EC:3.1.4.1]
synonym: "5'-NPDase activity" RELATED [EC:3.1.4.1]
synonym: "5'-nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.1]
synonym: "5'-PDase activity" RELATED [EC:3.1.4.1]
synonym: "5'-PDE activity" RELATED [EC:3.1.4.1]
synonym: "5'-phosphodiesterase activity" RELATED [EC:3.1.4.1]
synonym: "5'NPDE activity" RELATED [EC:3.1.4.1]
synonym: "alkaline phosphodiesterase activity" RELATED [EC:3.1.4.1]
synonym: "exonuclease I activity" RELATED [EC:3.1.4.1]
synonym: "nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [EC:3.1.4.1]
synonym: "oligonucleate 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.1]
synonym: "orthophosphoric diester phosphohydrolase activity" EXACT [EC:3.1.4.1]
synonym: "PDE I activity" EXACT [EC:3.1.4.1]
synonym: "phosphodiesterase activity" BROAD [EC:3.1.4.1]
xref: EC:3.1.4.1
xref: MetaCyc:3.1.4.1-RXN
is_a: GO:0004527 ! exonuclease activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0004529
name: exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0004527 ! exonuclease activity
is_a: GO:0004536 ! deoxyribonuclease activity

[Term]
id: GO:0004530
name: deoxyribonuclease I activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products." [EC:3.1.21.1]
subset: gosubset_prok
synonym: "alkaline deoxyribonuclease activity" EXACT [EC:3.1.21.1]
synonym: "alkaline DNase activity" EXACT [EC:3.1.21.1]
synonym: "deoxyribonuclease (pancreatic)" NARROW [EC:3.1.21.1]
synonym: "deoxyribonuclease A" RELATED [EC:3.1.21.1]
synonym: "deoxyribonucleic phosphatase activity" EXACT [EC:3.1.21.1]
synonym: "DNA depolymerase activity" EXACT [EC:3.1.21.1]
synonym: "DNA endonuclease activity" EXACT [EC:3.1.21.1]
synonym: "DNA nuclease activity" EXACT [EC:3.1.21.1]
synonym: "DNAase activity" EXACT [EC:3.1.21.1]
synonym: "DNase activity" NARROW [EC:3.1.21.1]
synonym: "DNase I" RELATED [EC:3.1.21.1]
synonym: "dornava" RELATED [EC:3.1.21.1]
synonym: "dornavac" RELATED [EC:3.1.21.1]
synonym: "endodeoxyribonuclease I" RELATED [EC:3.1.21.1]
synonym: "Escherichia coli endonuclease I" RELATED [EC:3.1.21.1]
synonym: "pancreatic deoxyribonuclease" NARROW [EC:3.1.21.1]
synonym: "pancreatic DNase activity" NARROW [EC:3.1.21.1]
synonym: "pancreatic dornase" NARROW [EC:3.1.21.1]
synonym: "thymonuclease activity" NARROW [EC:3.1.21.1]
synonym: "thymonuclease, dornase activity" EXACT [EC:3.1.21.1]
xref: EC:3.1.21.1
xref: MetaCyc:3.1.21.1-RXN
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0004531
name: deoxyribonuclease II activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products." [EC:3.1.22.1]
subset: gosubset_prok
synonym: "acid deoxyribonuclease activity" EXACT [EC:3.1.22.1]
synonym: "acid DNase activity" EXACT [EC:3.1.22.1]
synonym: "deoxyribonucleate 3'-nucleotidohydrolase activity" EXACT [EC:3.1.22.1]
synonym: "DNase II activity" EXACT [EC:3.1.22.1]
synonym: "lysosomal DNase II activity" NARROW [EC:3.1.22.1]
synonym: "pancreatic DNase II" RELATED [EC:3.1.22.1]
xref: EC:3.1.22.1
xref: MetaCyc:3.1.22.1-RXN
is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0004532
name: exoribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0004527 ! exonuclease activity
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0004533
name: exoribonuclease H activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions." [EC:3.1.13.2, ISBN:0198547684]
synonym: "retroviral reverse transcriptase RNaseH" RELATED [EC:3.1.13.2]
xref: EC:3.1.13.2
xref: MetaCyc:3.1.13.2-RXN
is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0004534
name: 5'-3' exoribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]
xref: EC:3.1.13.-
is_a: GO:0008409 ! 5'-3' exonuclease activity
is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0004535
name: poly(A)-specific ribonuclease activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684]
synonym: "2',3'-exoribonuclease activity" RELATED [EC:3.1.13.4]
synonym: "3'-exoribonuclease activity" EXACT [EC:3.1.13.4]
synonym: "poly(A)-specific RNase activity" EXACT []
xref: EC:3.1.13.4
xref: MetaCyc:3.1.13.4-RXN
is_a: GO:0000175 ! 3'-5'-exoribonuclease activity

[Term]
id: GO:0004536
name: deoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684]
comment: Consider also annotating to the molecular function term 'DNA binding ; GO:0003677'.
subset: gosubset_prok
is_a: GO:0004518 ! nuclease activity

[Term]
id: GO:0004537
name: caspase-activated deoxyribonuclease activity
namespace: molecular_function
xref: Reactome:12372 "caspase-activated deoxyribonuclease activity"
is_a: GO:0004536 ! deoxyribonuclease activity

[Term]
id: GO:0004540
name: ribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684]
comment: Consider also annotating to the molecular function term 'RNA binding ; GO:0003723'.
subset: gosubset_prok
is_a: GO:0004518 ! nuclease activity

[Term]
id: GO:0004549
name: tRNA-specific ribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules." [GOC:mah]
subset: gosubset_prok
synonym: "tRNA-specific RNase activity" EXACT []
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0004550
name: nucleoside diphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]
subset: gosubset_prok
synonym: "ATP:nucleoside-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6]
synonym: "NDK activity" EXACT [EC:2.7.4.6]
synonym: "nucleoside 5'-diphosphate kinase activity" EXACT [EC:2.7.4.6]
synonym: "nucleoside 5'-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6]
synonym: "nucleoside diphosphate (UDP) kinase activity" EXACT [EC:2.7.4.6]
synonym: "nucleoside diphosphokinase activity" EXACT [EC:2.7.4.6]
synonym: "nucleoside-diphosphate kinase activity" EXACT []
synonym: "nucleotide phosphate kinase activity" EXACT [EC:2.7.4.6]
synonym: "UDP kinase activity" EXACT [EC:2.7.4.6]
synonym: "uridine diphosphate kinase activity" EXACT [EC:2.7.4.6]
xref: EC:2.7.4.6
xref: MetaCyc:NUCLEOSIDE-DIP-KIN-RXN
xref: Reactome:12403 "nucleoside diphosphate kinase activity"
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity

[Term]
id: GO:0004551
name: nucleotide diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides." [EC:3.6.1.9]
subset: gosubset_prok
synonym: "dinucleotide nucleotidohydrolase activity" EXACT [EC:3.6.1.9]
synonym: "nucleotide pyrophosphatase activity" EXACT []
synonym: "nucleotide-sugar pyrophosphatase activity" EXACT [EC:3.6.1.9]
xref: EC:3.6.1.9
xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN
xref: Reactome:12405 "nucleotide diphosphatase activity"
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0004552
name: octanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-octanol + NAD+ = 1-octanal + NADH + H+." [EC:1.1.1.73]
synonym: "1-octanol dehydrogenase activity" EXACT [EC:1.1.1.73]
synonym: "octanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.73]
xref: EC:1.1.1.73
xref: MetaCyc:OCTANOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004553
name: hydrolase activity, hydrolyzing O-glycosyl compounds
namespace: molecular_function
alt_id: GO:0016800
def: "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah]
subset: gosubset_prok
synonym: "O-glucosyl hydrolase activity" EXACT []
xref: EC:3.2.1
is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds

[Term]
id: GO:0004555
name: alpha,alpha-trehalase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28]
subset: gosubset_prok
synonym: "alpha,alpha-trehalose glucohydrolase activity" EXACT [EC:3.2.1.28]
xref: EC:3.2.1.28
xref: MetaCyc:TREHALA-RXN
xref: Reactome:12414 "alpha,alpha-trehalase activity"
is_a: GO:0015927 ! trehalase activity

[Term]
id: GO:0004556
name: alpha-amylase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units." [EC:3.2.1.1]
subset: gosubset_prok
synonym: "1,4-alpha-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.1]
synonym: "alpha amylase activity" EXACT [EC:3.2.1.1]
synonym: "endoamylase activity" EXACT [EC:3.2.1.1]
synonym: "glycogenase activity" BROAD [EC:3.2.1.1]
synonym: "taka-amylase A" RELATED [EC:3.2.1.1]
xref: EC:3.2.1.1
xref: MetaCyc:ALPHA-AMYL-RXN
xref: MetaCyc:RXN-1823
xref: MetaCyc:RXN-1825
xref: Reactome:12418 "alpha-amylase activity"
is_a: GO:0016160 ! amylase activity

[Term]
id: GO:0004557
name: alpha-galactosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase." [EC:3.2.1.22]
subset: gosubset_prok
synonym: "alpha-D-galactosidase activity" EXACT [EC:3.2.1.22]
synonym: "alpha-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22]
synonym: "alpha-galactosidase A" RELATED [EC:3.2.1.22]
synonym: "alpha-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22]
synonym: "melibiase activity" EXACT []
xref: EC:3.2.1.22
xref: MetaCyc:ALPHAGALACTOSID-RXN
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0004558
name: alpha-glucosidase activity
namespace: molecular_function
alt_id: GO:0004562
alt_id: GO:0016982
def: "Catalysis of the hydrolysis of terminal, non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose." [EC:3.2.1.20]
subset: gosubset_prok
synonym: "acid maltase activity" EXACT [EC:3.2.1.20]
synonym: "alpha-1,4-glucosidase activity" EXACT [EC:3.2.1.20]
synonym: "alpha-D-glucosidase activity" EXACT [EC:3.2.1.20]
synonym: "alpha-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.20]
synonym: "alpha-glucopyranosidase activity" EXACT [EC:3.2.1.20]
synonym: "alpha-glucosidase II" RELATED []
synonym: "alpha-glucoside hydrolase activity" EXACT [EC:3.2.1.20]
synonym: "glucoinvertase activity" EXACT [EC:3.2.1.20]
synonym: "glucosidoinvertase activity" EXACT [EC:3.2.1.20]
synonym: "glucosidosucrase activity" EXACT [EC:3.2.1.20]
synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.20]
synonym: "maltase-glucoamylase activity" EXACT [EC:3.2.1.20]
xref: EC:3.2.1.20
xref: MetaCyc:MALTODEXGLUCOSID-RXN
xref: Reactome:12426 "alpha-glucosidase activity"
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0004559
name: alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24]
subset: gosubset_prok
synonym: "1,2-alpha-D-mannosidase activity" EXACT [EC:3.2.1.24]
synonym: "1,2-alpha-mannosidase" BROAD [EC:3.2.1.24]
synonym: "alpha-D-mannopyranosidase activity" EXACT [EC:3.2.1.24]
synonym: "alpha-D-mannosidase activity" EXACT [EC:3.2.1.24]
synonym: "alpha-D-mannoside mannohydrolase activity" EXACT [EC:3.2.1.24]
synonym: "exo-alpha-mannosidase activity" EXACT [EC:3.2.1.24]
synonym: "p-nitrophenyl-alpha-mannosidase activity" EXACT [EC:3.2.1.24]
xref: EC:3.2.1.24
xref: MetaCyc:3.2.1.24-RXN
is_a: GO:0015923 ! mannosidase activity

[Term]
id: GO:0004560
name: alpha-L-fucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose." [EC:3.2.1.51]
subset: gosubset_prok
synonym: "alpha-fucosidase activity" EXACT [EC:3.2.1.51]
synonym: "alpha-L-fucoside fucohydrolase activity" EXACT [EC:3.2.1.51]
xref: EC:3.2.1.51
xref: MetaCyc:ALPHA-L-FUCOSIDASE-RXN
is_a: GO:0015928 ! fucosidase activity

[Term]
id: GO:0004561
name: alpha-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides." [EC:3.2.1.50]
synonym: "alpha-acetylglucosaminidase activity" EXACT [EC:3.2.1.50]
synonym: "alpha-D-2-acetamido-2-deoxyglucosidase activity" EXACT [EC:3.2.1.50]
synonym: "alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity" EXACT [EC:3.2.1.50]
synonym: "N-acetyl-alpha-D-glucosaminidase activity" EXACT [EC:3.2.1.50]
synonym: "N-acetyl-alpha-glucosaminidase activity" EXACT [EC:3.2.1.50]
synonym: "NAG activity" EXACT [EC:3.2.1.50]
xref: EC:3.2.1.50
xref: MetaCyc:3.2.1.50-RXN
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0004563
name: beta-N-acetylhexosaminidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52]
subset: gosubset_prok
synonym: "beta-acetylaminodeoxyhexosidase activity" EXACT [EC:3.2.1.52]
synonym: "beta-acetylhexosaminidinase activity" EXACT [EC:3.2.1.52]
synonym: "beta-D-hexosaminidase activity" EXACT [EC:3.2.1.52]
synonym: "beta-D-N-acetylhexosaminidase activity" EXACT [EC:3.2.1.52]
synonym: "beta-hexosaminidase activity" EXACT [EC:3.2.1.52]
synonym: "beta-N-acetyl-D-hexosaminidase activity" EXACT [EC:3.2.1.52]
synonym: "beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity" EXACT [EC:3.2.1.52]
synonym: "hexosaminidase A" RELATED [EC:3.2.1.52]
synonym: "N-acetyl-beta-D-hexosaminidase activity" EXACT [EC:3.2.1.52]
synonym: "N-acetyl-beta-glucosaminidase activity" EXACT [EC:3.2.1.52]
synonym: "N-acetyl-beta-hexosaminidase activity" EXACT [EC:3.2.1.52]
synonym: "N-acetylhexosaminidase activity" EXACT [EC:3.2.1.52]
xref: EC:3.2.1.52
xref: MetaCyc:3.2.1.52-RXN
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0004564
name: beta-fructofuranosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides." [EC:3.2.1.26]
subset: gosubset_prok
synonym: "acid invertase activity" EXACT []
synonym: "alkaline invertase activity" EXACT []
synonym: "beta-D-fructofuranoside fructohydrolase activity" EXACT []
synonym: "beta-fructosidase activity" BROAD []
synonym: "beta-h-fructosidase activity" EXACT []
synonym: "fructosylinvertase activity" EXACT []
synonym: "glucosucrase activity" EXACT []
synonym: "invertase activity" BROAD []
synonym: "invertin activity" BROAD []
synonym: "maxinvert L 1000 activity" EXACT []
synonym: "saccharase activity" EXACT []
synonym: "sucrase activity" BROAD []
xref: EC:3.2.1.26
xref: MetaCyc:3.2.1.26-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004565
name: beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]
comment: Note that the inclusion of 'MetaCyc:BGALACT-PWY' is exceptional: normally MetaCyc pathway entries are database references for biological process terms, not molecular function terms. An exception was made in this case because the MetaCyc entry 'BGALACT-PWY' describes only one reaction, that catalyzed by beta-galactosidase.
subset: gosubset_prok
synonym: "beta-D-galactanase activity" EXACT [EC:3.2.1.23]
synonym: "beta-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.23]
synonym: "beta-D-lactosidase activity" EXACT [EC:3.2.1.23]
synonym: "beta-lactosidase activity" EXACT [EC:3.2.1.23]
synonym: "exo-(1->4)-beta-D-galactanase activity" EXACT [EC:3.2.1.23]
synonym: "hydrolact" RELATED [EC:3.2.1.23]
synonym: "lactose hydrolysis" RELATED []
synonym: "lactozym" RELATED [EC:3.2.1.23]
synonym: "maxilact" RELATED [EC:3.2.1.23]
synonym: "oryzatym" RELATED [EC:3.2.1.23]
synonym: "S 2107" RELATED [EC:3.2.1.23]
synonym: "sumiklat" RELATED [EC:3.2.1.23]
synonym: "trilactase activity" EXACT [EC:3.2.1.23]
xref: EC:3.2.1.23
xref: MetaCyc:3.2.1.23-RXN
xref: MetaCyc:BGALACT-PWY
is_a: GO:0015925 ! galactosidase activity

[Term]
id: GO:0004566
name: beta-glucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31]
subset: gosubset_prok
synonym: "beta-D-glucuronoside glucuronosohydrolase activity" EXACT [EC:3.2.1.31]
synonym: "beta-glucuronide glucuronohydrolase activity" EXACT [EC:3.2.1.31]
synonym: "exo-beta-D-glucuronidase activity" EXACT [EC:3.2.1.31]
synonym: "glucuronidase activity" EXACT [EC:3.2.1.31]
synonym: "ketodase activity" EXACT [EC:3.2.1.31]
xref: EC:3.2.1.31
xref: MetaCyc:BETA-GLUCURONID-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004567
name: beta-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides." [EC:3.2.1.25]
subset: gosubset_prok
synonym: "beta-D-mannosidase activity" EXACT [EC:3.2.1.25]
synonym: "beta-D-mannoside mannohydrolase activity" EXACT [EC:3.2.1.25]
synonym: "beta-mannoside mannohydrolase activity" EXACT [EC:3.2.1.25]
synonym: "exo-beta-D-mannanase activity" EXACT [EC:3.2.1.25]
synonym: "mannanase activity" EXACT [EC:3.2.1.25]
synonym: "mannase activity" EXACT [EC:3.2.1.25]
xref: EC:3.2.1.25
xref: MetaCyc:3.2.1.25-RXN
is_a: GO:0015923 ! mannosidase activity

[Term]
id: GO:0004568
name: chitinase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins." [EC:3.2.1.14]
subset: gosubset_prok
synonym: "1,4-beta-poly-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.14]
synonym: "beta-1,4-poly-N-acetyl glucosamidinase activity" EXACT [EC:3.2.1.14]
synonym: "chitodextrinase activity" EXACT [EC:3.2.1.14]
synonym: "poly-beta-glucosaminidase activity" EXACT [EC:3.2.1.14]
synonym: "poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity" EXACT [EC:3.2.1.14]
xref: EC:3.2.1.14
xref: MetaCyc:3.2.1.14-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004569
name: glycoprotein endo-alpha-1,2-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane." [EC:3.2.1.130]
synonym: "endo-alpha-mannosidase activity" EXACT [EC:3.2.1.130]
synonym: "endomannosidase activity" EXACT [EC:3.2.1.130]
synonym: "glucosyl mannosidase activity" EXACT [EC:3.2.1.130]
synonym: "glucosylmannosidase activity" EXACT [EC:3.2.1.130]
synonym: "glycoprotein glucosylmannohydrolase activity" EXACT [EC:3.2.1.130]
xref: EC:3.2.1.130
xref: MetaCyc:3.2.1.130-RXN
is_a: GO:0004559 ! alpha-mannosidase activity

[Term]
id: GO:0004571
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [EC:3.2.1.113]
subset: gosubset_prok
synonym: "1,2-alpha-mannosidase" BROAD [EC:3.2.1.113]
synonym: "1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [EC:3.2.1.113]
synonym: "exo-alpha-1,2-mannanase activity" EXACT [EC:3.2.1.113]
synonym: "glycoprotein processing mannosidase I" RELATED [EC:3.2.1.113]
synonym: "man9-mannosidase activity" RELATED [EC:3.2.1.113]
synonym: "Man9-mannosidase activity" EXACT [EC:3.2.1.113]
synonym: "ManI activity" NARROW [EC:3.2.1.113]
synonym: "mannose-9 processing alpha-mannosidase activity" EXACT [EC:3.2.1.113]
synonym: "mannosidase 1A activity" NARROW [EC:3.2.1.113]
synonym: "mannosidase 1B activity" NARROW [EC:3.2.1.113]
synonym: "mannosidase I" RELATED [EC:3.2.1.113]
xref: EC:3.2.1.113
xref: MetaCyc:3.2.1.113-RXN
is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity

[Term]
id: GO:0004572
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the terminal 1,3- and 1,6-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)." [EC:3.2.1.114]
synonym: "1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [EC:3.2.1.114]
synonym: "alpha-D-mannosidase II" RELATED [EC:3.2.1.114]
synonym: "alpha-mannosidase II" RELATED [EC:3.2.1.114]
synonym: "alpha1-3,6-mannosidase activity" EXACT [EC:3.2.1.114]
synonym: "exo-1,3-1,6-alpha-mannosidase activity" EXACT [EC:3.2.1.114]
synonym: "GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity" EXACT [EC:3.2.1.114]
synonym: "Golgi alpha-mannosidase II" RELATED [EC:3.2.1.114]
synonym: "ManII activity" NARROW [EC:3.2.1.114]
synonym: "mannosidase II activity" NARROW [EC:3.2.1.114]
xref: EC:3.2.1.114
xref: MetaCyc:3.2.1.114-RXN
is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity

[Term]
id: GO:0004573
name: mannosyl-oligosaccharide glucosidase activity
namespace: molecular_function
def: "Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)." [EC:3.2.1.106]
synonym: "Glc3Man9NAc2 oligosaccharide glucosidase activity" EXACT [EC:3.2.1.106]
synonym: "mannosyl-oligosaccharide glucohydrolase activity" EXACT [EC:3.2.1.106]
synonym: "mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity" EXACT []
synonym: "processing A-glucosidase I activity" RELATED [EC:3.2.1.106]
synonym: "trimming glucosidase I" RELATED [EC:3.2.1.106]
xref: EC:3.2.1.106
xref: MetaCyc:3.2.1.106-RXN
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0004574
name: oligo-1,6-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of 1,6-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose." [EC:3.2.1.10]
subset: gosubset_prok
synonym: "alpha-limit dextrinase activity" EXACT [EC:3.2.1.10]
synonym: "dextrin 6-glucanohydrolase activity" EXACT [EC:3.2.1.10]
synonym: "dextrin 6alpha-glucanohydrolase activity" EXACT [EC:3.2.1.10]
synonym: "exo-oligo-1,6-glucosidase activity" EXACT [EC:3.2.1.10]
synonym: "isomaltase activity" RELATED [EC:3.2.1.10]
synonym: "limit dextrinase (erroneous)" BROAD [EC:3.2.1.10]
synonym: "oligosaccharide alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.10]
synonym: "oligosaccharide alpha-1,6-glucosidase activity" EXACT [EC:3.2.1.10]
synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.10]
xref: EC:3.2.1.10
xref: MetaCyc:3.2.1.10-RXN
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0004575
name: sucrose alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type action." [EC:3.2.1.48]
synonym: "intestinal sucrase activity" EXACT [EC:3.2.1.48]
synonym: "sucrase activity" EXACT [EC:3.2.1.48]
synonym: "sucrase(invertase)" RELATED [EC:3.2.1.48]
synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.48]
synonym: "sucrose alpha-D-glucohydrolase activity" EXACT []
synonym: "sucrose alpha-glucohydrolase activity" EXACT [EC:3.2.1.48]
synonym: "sucrose-alpha-D-glucohydrolase activity" EXACT [EC:3.2.1.48]
synonym: "sucrose.alpha.-glucohydrolase activity" EXACT [EC:3.2.1.48]
xref: EC:3.2.1.48
xref: MetaCyc:3.2.1.48-RXN
xref: Reactome:12493 "sucrose alpha-glucosidase activity"
is_a: GO:0004558 ! alpha-glucosidase activity

[Term]
id: GO:0004576
name: oligosaccharyl transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
subset: gosubset_prok
synonym: "oligosaccharide transferase activity" EXACT [EC:2.4.1.119, GOC:mah]
xref: EC:2.4.1.-
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0004577
name: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol." [EC:2.4.1.141]
synonym: "N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.4.1.141]
synonym: "UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity" EXACT [EC:2.4.1.141]
synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.141]
synonym: "uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.141]
xref: EC:2.4.1.141
xref: MetaCyc:2.4.1.141-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0004578
name: chitobiosyldiphosphodolichol beta-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol." [EC:2.4.1.142]
synonym: "GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity" EXACT [EC:2.4.1.142]
synonym: "GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.142]
synonym: "guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity" EXACT [EC:2.4.1.142]
xref: EC:2.4.1.142
xref: MetaCyc:2.4.1.142-RXN
is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity

[Term]
id: GO:0004579
name: dolichyl-diphosphooligosaccharide-protein glycotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119]
synonym: "asparagine N-glycosyltransferase activity" EXACT [EC:2.4.1.119]
synonym: "dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity" EXACT []
synonym: "dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity" EXACT [EC:2.4.1.119]
synonym: "dolichyldiphosphooligosaccharide-protein glycosyltransferase activity" EXACT [EC:2.4.1.119]
synonym: "dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity" EXACT [EC:2.4.1.119]
synonym: "dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity" EXACT [EC:2.4.1.119]
synonym: "dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity" EXACT [EC:2.4.1.119]
synonym: "oligomannosyltransferase activity" RELATED [EC:2.4.1.119]
xref: EC:2.4.1.119
xref: MetaCyc:2.4.1.119-RXN
is_a: GO:0004576 ! oligosaccharyl transferase activity

[Term]
id: GO:0004581
name: dolichyl-phosphate beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate." [EC:2.4.1.117]
subset: gosubset_prok
synonym: "polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity" EXACT [EC:2.4.1.117]
synonym: "UDP-glucose dolichyl-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117]
synonym: "UDP-glucose:dolichol phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117]
synonym: "UDP-glucose:dolicholphosphoryl glucosyltransferase activity" EXACT [EC:2.4.1.117]
synonym: "UDP-glucose:dolichyl monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.117]
synonym: "UDP-glucose:dolichyl phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117]
synonym: "UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.117]
synonym: "UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.117]
synonym: "uridine diphosphoglucose-dolichol glucosyltransferase activity" EXACT [EC:2.4.1.117]
xref: EC:2.4.1.117
xref: MetaCyc:2.4.1.117-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0004582
name: dolichyl-phosphate beta-D-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate." [EC:2.4.1.83]
subset: gosubset_prok
synonym: "dolichol phosphate mannose synthase activity" EXACT [EC:2.4.1.83]
synonym: "dolichol-phosphate mannose synthase activity" EXACT [EC:2.4.1.83]
synonym: "dolichol-phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83]
synonym: "dolichol-phosphate-mannose synthase activity" EXACT []
synonym: "dolichyl mannosyl phosphate synthase activity" EXACT [EC:2.4.1.83]
synonym: "dolichyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83]
synonym: "dolichyl-phosphate mannose synthase activity" EXACT [EC:2.4.1.83]
synonym: "dolichyl-phospho-mannose synthase activity" EXACT [EC:2.4.1.83]
synonym: "DPM synthase activity" EXACT []
synonym: "GDP-mannose-dolichol phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83]
synonym: "GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.83]
synonym: "GDPMan:DolP mannosyltransferase activity" EXACT [EC:2.4.1.83]
synonym: "GDPmannose-dolichylmonophosphate mannosyltransferase activity" EXACT [EC:2.4.1.83]
synonym: "GDPmannose:dolichyl-phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83]
synonym: "guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83]
synonym: "mannosylphosphodolichol synthase activity" EXACT [EC:2.4.1.83]
synonym: "mannosylphosphoryldolichol synthase activity" EXACT [EC:2.4.1.83]
xref: EC:2.4.1.83
xref: MetaCyc:2.4.1.83-RXN
xref: Reactome:12521 "dolichyl-phosphate beta-D-mannosyltransferase activity"
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0004583
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide." [GOC:mah]
xref: EC:2.4.1.-
xref: MetaCyc:RXN-5472
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0004584
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide." [EC:2.4.1.130]
synonym: "dolichol phosphomannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.130]
synonym: "dolichyl-phosphate-D-mannose:glycolipid alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.130]
synonym: "oligomannosylsynthase activity" EXACT [EC:2.4.1.130]
xref: EC:2.4.1.130
xref: MetaCyc:2.4.1.130-RXN
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0004585
name: ornithine carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [EC:2.1.3.3]
subset: gosubset_prok
synonym: "carbamoyl-phosphate:L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3]
synonym: "carbamylphosphate-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3]
synonym: "citrulline phosphorylase activity" EXACT [EC:2.1.3.3]
synonym: "L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3]
synonym: "L-ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3]
synonym: "L-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3]
synonym: "ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3]
synonym: "ornithine transcarbamylase activity" EXACT [EC:2.1.3.3]
synonym: "OTC activity" EXACT [EC:2.1.3.3]
synonym: "OTCase activity" EXACT [EC:2.1.3.3]
xref: EC:2.1.3.3
xref: MetaCyc:ORNCARBAMTRANSFER-RXN
xref: Reactome:12530 "ornithine carbamoyltransferase activity"
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0004586
name: ornithine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine = putrescine + CO2." [EC:4.1.1.17]
subset: gosubset_prok
synonym: "L-ornithine carboxy-lyase (putrescine-forming)" EXACT [EC:4.1.1.17]
synonym: "L-ornithine carboxy-lyase activity" NARROW [EC:4.1.1.17]
synonym: "SpeC" RELATED [EC:4.1.1.17]
xref: EC:4.1.1.17
xref: MetaCyc:ORNDECARBOX-RXN
xref: Reactome:12531 "ornithine decarboxylase activity"
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004587
name: ornithine-oxo-acid transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid." [EC:2.6.1.13]
subset: gosubset_prok
synonym: "GabT" RELATED [EC:2.6.1.13]
synonym: "L-ornithine 5-aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "L-ornithine aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "L-ornithine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "L-ornithine:alpha-ketoglutarate delta-aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "OAT" RELATED [EC:2.6.1.13]
synonym: "ornithine 5-aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine delta-transaminase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine ketoacid aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine transaminase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine--2-oxoacid aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine--alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine--keto acid aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine--keto acid transaminase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine--ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine--oxo acid aminotransferase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine--oxo-acid transaminase activity" EXACT [EC:2.6.1.13]
synonym: "ornithine-oxo-acid aminotransferase activity" EXACT []
synonym: "ornithine:alpha-oxoglutarate transaminase activity" EXACT [EC:2.6.1.13]
xref: EC:2.6.1.13
xref: MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN
xref: Reactome:12532 "ornithine-oxo-acid transaminase activity"
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004588
name: orotate phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.10]
subset: gosubset_prok
synonym: "OPRT activity" EXACT [EC:2.4.2.10]
synonym: "OPRTase activity" EXACT [EC:2.4.2.10]
synonym: "orotate phosphoribosyl pyrophosphate transferase activity" EXACT [EC:2.4.2.10]
synonym: "orotic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.10]
synonym: "orotidine 5'-monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10]
synonym: "orotidine monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10]
synonym: "orotidine phosphoribosyltransferase activity" EXACT [EC:2.4.2.10]
synonym: "orotidine-5'-phosphate diphosphorylase activity" EXACT [EC:2.4.2.10]
synonym: "orotidine-5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10]
synonym: "orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.10]
synonym: "orotidylate phosphoribosyltransferase activity" EXACT [EC:2.4.2.10]
synonym: "orotidylate pyrophosphorylase activity" EXACT [EC:2.4.2.10]
synonym: "orotidylic acid phosphorylase activity" EXACT [EC:2.4.2.10]
synonym: "orotidylic acid pyrophosphorylase activity" EXACT [EC:2.4.2.10]
synonym: "orotidylic phosphorylase activity" EXACT [EC:2.4.2.10]
synonym: "orotidylic pyrophosphorylase activity" EXACT [EC:2.4.2.10]
xref: EC:2.4.2.10
xref: MetaCyc:OROPRIBTRANS-RXN
xref: Reactome:12534 "orotate phosphoribosyltransferase activity"
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004589
name: orotate reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + NAD+ = orotate + NADH + H+." [EC:1.3.1.14]
synonym: "(S)-dihydroorotate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.14]
xref: EC:1.3.1.14
xref: MetaCyc:OROTATE-REDUCTASE-NADH-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004590
name: orotidine-5'-phosphate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: orotidine 5'-phosphate = UMP + CO2." [EC:4.1.1.23]
subset: gosubset_prok
synonym: "ODCase activity" EXACT [EC:4.1.1.23]
synonym: "OMP decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "OMP-DC" RELATED [EC:4.1.1.23]
synonym: "OMPdcase activity" EXACT [EC:4.1.1.23]
synonym: "orotate decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotate monophosphate decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotic decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotidine 5'-phosphate decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotidine monophosphate decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotidine phosphate decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotidine-5'-monophosphate decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotidine-5'-phosphate carboxy-lyase (UMP-forming)" EXACT [EC:4.1.1.23]
synonym: "orotidine-5'-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.23]
synonym: "orotidylic acid decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotidylic decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "orotodylate decarboxylase activity" EXACT [EC:4.1.1.23]
synonym: "UMP synthase activity" EXACT [EC:4.1.1.23]
synonym: "uridine 5'-monophosphate synthase activity" EXACT [EC:4.1.1.23]
xref: EC:4.1.1.23
xref: MetaCyc:OROTPDECARB-RXN
xref: Reactome:12548 "orotidine-5'-phosphate decarboxylase activity"
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004591
name: oxoglutarate dehydrogenase (succinyl-transferring) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2." [EC:1.2.4.2]
subset: gosubset_prok
synonym: "2-ketoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2]
synonym: "2-oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2]
synonym: "2-oxoglutarate: lipoate oxidoreductase activity" EXACT [EC:1.2.4.2]
synonym: "2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)" EXACT [EC:1.2.4.2]
synonym: "2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity" EXACT [EC:1.2.4.2]
synonym: "AKGDH activity" EXACT [EC:1.2.4.2]
synonym: "alpha-ketoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2]
synonym: "alpha-ketoglutaric acid dehydrogenase activity" EXACT [EC:1.2.4.2]
synonym: "alpha-ketoglutaric dehydrogenase activity" EXACT [EC:1.2.4.2]
synonym: "alpha-oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2]
synonym: "ketoglutaric dehydrogenase activity" EXACT [EC:1.2.4.2]
synonym: "OGDC activity" EXACT [EC:1.2.4.2]
synonym: "oxoglutarate decarboxylase activity" EXACT [EC:1.2.4.2]
synonym: "oxoglutarate dehydrogenase (lipoamide) activity" EXACT []
synonym: "oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2]
xref: EC:1.2.4.2
xref: MetaCyc:2OXOGLUTDECARB-RXN
is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

[Term]
id: GO:0004592
name: pantoate-beta-alanine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate." [EC:6.3.2.1]
subset: gosubset_prok
synonym: "(R)-pantoate:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.1]
synonym: "D-pantoate:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.1]
synonym: "pantoate-activating enzyme activity" RELATED [EC:6.3.2.1]
synonym: "pantoic-activating enzyme activity" RELATED [EC:6.3.2.1]
synonym: "pantothenate synthetase activity" EXACT [EC:6.3.2.1]
xref: EC:6.3.2.1
xref: MetaCyc:PANTOATE-BETA-ALANINE-LIG-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004593
name: pantothenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pantothenate + H2O = pantoate + beta-alanine." [EC:3.5.1.22]
synonym: "(R)-pantothenate amidohydrolase activity" EXACT [EC:3.5.1.22]
synonym: "pantothenate amidohydrolase activity" EXACT [EC:3.5.1.22]
synonym: "pantothenate hydrolase activity" EXACT [EC:3.5.1.22]
xref: EC:3.5.1.22
xref: MetaCyc:PANTOTHENASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0004594
name: pantothenate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33]
subset: gosubset_prok
synonym: "ATP:(R)-pantothenate 4'-phosphotransferase activity" EXACT [EC:2.7.1.33]
synonym: "ATP:pantothenate 4'-phosphotransferase activity" EXACT [EC:2.7.1.33]
synonym: "D-pantothenate kinase activity" EXACT [EC:2.7.1.33]
synonym: "pantothenate kinase (phosphorylating) activity" EXACT [EC:2.7.1.33]
synonym: "pantothenic acid kinase activity" EXACT [EC:2.7.1.33]
xref: EC:2.7.1.33
xref: MetaCyc:PANTOTHENATE-KIN-RXN
xref: Reactome:12562 "pantothenate kinase activity"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004595
name: pantetheine-phosphate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pantetheine 4'-phosphate = diphosphate + dephospho-CoA." [EC:2.7.7.3]
subset: gosubset_prok
synonym: "3'-dephospho-CoA pyrophosphorylase activity" EXACT [EC:2.7.7.3]
synonym: "ATP:pantetheine-4'-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.3]
synonym: "ATP:pantetheine-phosphate adenylyltransferase activity" EXACT []
synonym: "dephospho-CoA diphosphorylase activity" EXACT [EC:2.7.7.3]
synonym: "dephospho-CoA pyrophosphorylase activity" EXACT [EC:2.7.7.3]
synonym: "dephospho-coenzyme A pyrophosphorylase activity" EXACT [EC:2.7.7.3]
synonym: "pantetheine phosphate adenylyltransferase activity" EXACT [EC:2.7.7.3]
synonym: "phosphopantetheine adenylyltransferase activity" EXACT []
synonym: "PPAT activity" EXACT [EC:2.7.7.3]
xref: EC:2.7.7.3
xref: MetaCyc:PANTEPADENYLYLTRAN-RXN
xref: Reactome:12566 "pantetheine-phosphate adenylyltransferase activity"
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0004596
name: peptide alpha-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the acetylation of the N-terminal amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide." [EC:2.3.1.88, GOC:mah]
subset: gosubset_prok
synonym: "acetyl-CoA:peptide alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.88]
synonym: "acetyl-CoA:peptide nalpha-acetyltransferase activity" EXACT [EC:2.3.1.88]
synonym: "amino-terminal amino acid-acetylating enzyme activity" RELATED [EC:2.3.1.88]
synonym: "beta-endorphin acetyltransferase activity" NARROW [EC:2.3.1.88]
synonym: "N(alpha)-acetyltransferase activity" RELATED [EC:2.3.1.88]
synonym: "nalpha-acetyltransferase activity" EXACT [EC:2.3.1.88]
synonym: "NAT activity" RELATED [EC:2.3.1.88]
synonym: "peptide acetyltransferase activity" RELATED [EC:2.3.1.88]
synonym: "protein N-terminal acetyltransferase activity" EXACT [EC:2.3.1.88]
xref: EC:2.3.1.88
xref: MetaCyc:PEPTIDE-ALPHA-N-ACETYLTRANSFERASE-RXN
is_a: GO:0034212 ! peptide N-acetyltransferase activity

[Term]
id: GO:0004597
name: peptide-aspartate beta-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2." [EC:1.14.11.16]
subset: gosubset_prok
synonym: "aspartate beta-hydroxylase activity" EXACT [EC:1.14.11.16]
synonym: "aspartyl/asparaginyl beta-hydroxylase activity" RELATED [EC:1.14.11.16]
synonym: "aspartylpeptide beta-dioxygenase activity" EXACT [EC:1.14.11.16]
synonym: "peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.16]
xref: EC:1.14.11.16
xref: MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0004598
name: peptidylamidoglycolate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate." [EC:4.3.2.5]
synonym: "alpha-hydroxyglycine amidating dealkylase activity" EXACT [EC:4.3.2.5]
synonym: "HGAD" RELATED [EC:4.3.2.5]
synonym: "PAL" RELATED [EC:4.3.2.5]
synonym: "peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity" EXACT [EC:4.3.2.5]
synonym: "peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)" EXACT [EC:4.3.2.5]
synonym: "peptidylamidoglycolate peptidylamide-lyase activity" EXACT [EC:4.3.2.5]
synonym: "PGL" RELATED [EC:4.3.2.5]
xref: EC:4.3.2.5
xref: MetaCyc:PEPTIDYLAMIDOGLYCOLATE-LYASE-RXN
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0004600
name: cyclophilin
namespace: molecular_function
def: "OBSOLETE. A protein to which cyclosporin A (an immunosuppressant) binds. Possesses peptidyl-prolyl isomerase activity." [EC:5.2.1.8, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
consider: GO:0003755
consider: GO:0016018

[Term]
id: GO:0004601
name: peroxidase activity
namespace: molecular_function
alt_id: GO:0016685
alt_id: GO:0016686
alt_id: GO:0016687
alt_id: GO:0016693
def: "Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O." [EC:1.11.1.7]
subset: gosubset_prok
synonym: "bacterial catalase-peroxidase activity" NARROW []
synonym: "donor:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.7]
synonym: "eosinophil peroxidase activity" NARROW []
synonym: "extensin peroxidase" NARROW [EC:1.11.1.7]
synonym: "guaiacol peroxidase" NARROW [EC:1.11.1.7]
synonym: "heme peroxidase" NARROW [EC:1.11.1.7]
synonym: "horseradish peroxidase (HRP)" NARROW [EC:1.11.1.7]
synonym: "japanese radish peroxidase" NARROW [EC:1.11.1.7]
synonym: "lactoperoxidase activity" NARROW []
synonym: "MPO" RELATED [EC:1.11.1.7]
synonym: "myeloperoxidase activity" NARROW []
synonym: "oxyperoxidase activity" EXACT [EC:1.11.1.7]
synonym: "peroxidase reaction" EXACT []
synonym: "protoheme peroxidase" NARROW [EC:1.11.1.7]
synonym: "pyrocatechol peroxidase" NARROW [EC:1.11.1.7]
synonym: "scopoletin peroxidase" NARROW [EC:1.11.1.7]
synonym: "secretory plant peroxidase activity" NARROW []
synonym: "thiocyanate peroxidase" NARROW [EC:1.11.1.7]
synonym: "verdoperoxidase" NARROW [EC:1.11.1.7]
xref: EC:1.11.1.-
xref: EC:1.11.1.7
xref: MetaCyc:PEROXID-RXN
xref: Reactome:4411 "peroxidase activity"
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor

[Term]
id: GO:0004602
name: glutathione peroxidase activity
namespace: molecular_function
alt_id: GO:0016224
def: "Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O." [EC:1.11.1.9]
subset: gosubset_prok
synonym: "glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.9]
synonym: "GSH peroxidase activity" EXACT [EC:1.11.1.9]
synonym: "non-selenium glutathione peroxidase activity" NARROW []
synonym: "reduced glutathione peroxidase activity" EXACT [EC:1.11.1.9]
synonym: "selenium-glutathione peroxidase activity" EXACT [EC:1.11.1.9]
xref: EC:1.11.1.9
xref: MetaCyc:GLUTATHIONE-PEROXIDASE-RXN
xref: Reactome:13237 "glutathione peroxidase activity"
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0004603
name: phenylethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine." [EC:2.1.1.28]
synonym: "noradrenalin N-methyltransferase activity" EXACT [EC:2.1.1.28]
synonym: "noradrenaline N-methyltransferase activity" RELATED [EC:2.1.1.28]
synonym: "norepinephrine methyltransferase activity" EXACT [EC:2.1.1.28]
synonym: "norepinephrine N-methyltransferase activity" EXACT [EC:2.1.1.28]
synonym: "phenethanolamine methyltransferase activity" EXACT [EC:2.1.1.28]
synonym: "phenethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.28]
synonym: "S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.28]
xref: EC:2.1.1.28
xref: MetaCyc:2.1.1.28-RXN
xref: Reactome:13238 "phenylethanolamine N-methyltransferase activity"
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004604
name: phosphoadenylyl-sulfate reductase (thioredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenosine 5'-phosphosulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS." [EC:1.8.4.8]
subset: gosubset_prok
synonym: "3'-phosphoadenylylsulfate reductase activity" EXACT [EC:1.8.4.8]
synonym: "adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.8]
synonym: "adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.8]
synonym: "PAdoPS reductase activity" EXACT [EC:1.8.4.8]
synonym: "PAPS reductase activity" EXACT [EC:1.8.4.8]
synonym: "PAPS reductase, thioredoxin-dependent activity" EXACT [EC:1.8.4.8]
synonym: "PAPS sulfotransferase activity" EXACT [EC:1.8.4.8]
synonym: "phosphoadenosine-phosphosulfate reductase activity" EXACT [EC:1.8.4.8]
synonym: "phosphoadenylyl-sulphate reductase (thioredoxin) activity" EXACT []
synonym: "thioredoxin:3'-phospho-adenylylsulfate reductase activity" EXACT [EC:1.8.4.8]
synonym: "thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity" EXACT [EC:1.8.4.8]
xref: EC:1.8.4.8
xref: MetaCyc:1.8.4.8-RXN
is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0004605
name: phosphatidate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol." [EC:2.7.7.41]
subset: gosubset_prok
synonym: "CDP diglyceride pyrophosphorylase activity" EXACT [EC:2.7.7.41]
synonym: "CDP-DG" RELATED [EC:2.7.7.41]
synonym: "CDP-diacylglyceride synthetase activity" EXACT [EC:2.7.7.41]
synonym: "CDP-diacylglycerol synthase activity" EXACT []
synonym: "CDP-diglyceride diphosphorylase activity" EXACT []
synonym: "CDP-diglyceride pyrophosphorylase activity" EXACT []
synonym: "CDP-diglyceride synthase activity" EXACT []
synonym: "CDP-diglyceride synthetase activity" EXACT [EC:2.7.7.41]
synonym: "CTP-diacylglycerol synthetase activity" EXACT [EC:2.7.7.41]
synonym: "CTP:1,2-diacylglycerophosphate-cytidyl transferase activity" EXACT [EC:2.7.7.41]
synonym: "CTP:phosphatidate cytidylyltransferase activity" EXACT [EC:2.7.7.41]
synonym: "cytidine diphosphoglyceride pyrophosphorylase activity" EXACT [EC:2.7.7.41]
synonym: "DAG synthetase activity" EXACT [EC:2.7.7.41]
synonym: "phosphatidate cytidyltransferase activity" EXACT [EC:2.7.7.41]
synonym: "phosphatidic acid cytidylyltransferase activity" EXACT [EC:2.7.7.41]
xref: EC:2.7.7.41
xref: MetaCyc:CDPDIGLYSYN-RXN
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0004607
name: phosphatidylcholine-sterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine." [EC:2.3.1.43]
subset: gosubset_prok
synonym: "LCAT (lecithin-cholesterol acyltransferase)" RELATED [EC:2.3.1.43]
synonym: "LCAT activity" EXACT [EC:2.3.1.43]
synonym: "lecithin--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43]
synonym: "lecithin:cholesterol acyltransferase activity" EXACT [EC:2.3.1.43]
synonym: "phosphatidylcholine:sterol O-acyltransferase activity" EXACT [EC:2.3.1.43]
synonym: "phospholipid--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43]
xref: EC:2.3.1.43
xref: MetaCyc:2.3.1.43-RXN
xref: Reactome:13245 "phosphatidylcholine-sterol O-acyltransferase activity"
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0004608
name: phosphatidylethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine." [EC:2.1.1.17]
subset: gosubset_prok
synonym: "lipid methyl transferase activity" EXACT [EC:2.1.1.17]
synonym: "LMTase activity" EXACT [EC:2.1.1.17]
synonym: "PEMT" RELATED [EC:2.1.1.17]
synonym: "phosphatidylethanolamine methyltransferase activity" EXACT [EC:2.1.1.17]
synonym: "phosphatidylethanolamine-N-methylase activity" EXACT [EC:2.1.1.17]
synonym: "phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity" EXACT [EC:2.1.1.17]
synonym: "S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.17]
xref: EC:2.1.1.17
xref: MetaCyc:2.1.1.17-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004609
name: phosphatidylserine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidyl-L-serine = phosphatidylethanolamine + CO2." [EC:4.1.1.65]
subset: gosubset_prok
synonym: "phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)" EXACT [EC:4.1.1.65]
synonym: "phosphatidyl-L-serine carboxy-lyase activity" EXACT [EC:4.1.1.65]
synonym: "PS decarboxylase activity" EXACT [EC:4.1.1.65]
xref: EC:4.1.1.65
xref: MetaCyc:PHOSPHASERDECARB-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004610
name: phosphoacetylglucosamine mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate." [EC:5.4.2.3]
subset: gosubset_prok
synonym: "acetylaminodeoxyglucose phosphomutase activity" EXACT [EC:5.4.2.3]
synonym: "acetylglucosamine phosphomutase activity" EXACT [EC:5.4.2.3]
synonym: "N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.3]
synonym: "N-acetyl-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.3]
synonym: "N-acetylglucosamine-phosphate mutase activity" EXACT [EC:5.4.2.3]
synonym: "phospho-N-acetylglucosamine mutase activity" EXACT [EC:5.4.2.3]
xref: EC:5.4.2.3
xref: MetaCyc:PHOSACETYLGLUCOSAMINEMUT-RXN
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0004611
name: phosphoenolpyruvate carboxykinase activity
namespace: molecular_function
def: "Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2." [EC:4.1.1.-]
subset: gosubset_prok
synonym: "PEP carboxykinase activity" EXACT [EC:4.1.1.-]
synonym: "PEPCK activity" EXACT [EC:4.1.1.-]
synonym: "phosphopyruvate carboxylase activity" EXACT [EC:4.1.1.-]
xref: EC:4.1.1.-
xref: MetaCyc:4.1.1.32-RXN
xref: MetaCyc:PEPCARBOXYKIN-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004612
name: phosphoenolpyruvate carboxykinase (ATP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2." [EC:4.1.1.49]
subset: gosubset_prok
synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.49]
synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.49]
synonym: "PEPCK (ATP)" RELATED [EC:4.1.1.49]
synonym: "PEPK" RELATED [EC:4.1.1.49]
synonym: "phosphoenolpyruvate carboxylase (ATP)" EXACT [EC:4.1.1.49]
synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.49]
synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.49]
synonym: "phosphopyruvate carboxykinase (adenosine triphosphate)" EXACT [EC:4.1.1.49]
synonym: "phosphopyruvate carboxylase (ATP)" EXACT [EC:4.1.1.49]
xref: EC:4.1.1.49
xref: MetaCyc:PEPCARBOXYKIN-RXN
is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity

[Term]
id: GO:0004613
name: phosphoenolpyruvate carboxykinase (GTP) activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2." [EC:4.1.1.32]
subset: gosubset_prok
synonym: "GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.32]
synonym: "GTP:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.32]
synonym: "phosphoenolpyruvate carboxylase (GTP)" EXACT []
synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.32]
synonym: "phosphoenolpyruvic carboxykinase (GTP)" EXACT [EC:4.1.1.32]
synonym: "phosphoenolpyruvic carboxylase (GTP)" EXACT [EC:4.1.1.32]
synonym: "phosphopyruvate (guanosine triphosphate) carboxykinase activity" EXACT [EC:4.1.1.32]
synonym: "phosphopyruvate carboxylase (GTP)" EXACT [EC:4.1.1.32]
xref: EC:4.1.1.32
xref: MetaCyc:4.1.1.32-RXN
xref: Reactome:13265 "phosphoenolpyruvate carboxykinase (GTP) activity"
is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity

[Term]
id: GO:0004614
name: phosphoglucomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate." [EC:5.4.2.2]
subset: gosubset_prok
synonym: "alpha-D-glucose 1,6-phosphomutase activity" EXACT [EC:5.4.2.2]
synonym: "glucose phosphomutase activity" EXACT [EC:5.4.2.2]
synonym: "phosphoglucose mutase activity" EXACT [EC:5.4.2.2]
xref: EC:5.4.2.2
xref: MetaCyc:PHOSPHOGLUCMUT-RXN
xref: Reactome:13266 "phosphoglucomutase activity"
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0004615
name: phosphomannomutase activity
namespace: molecular_function
alt_id: GO:0008971
def: "Catalysis of the reaction: D-mannose 1-phosphate = D-mannose 6-phosphate." [EC:5.4.2.8]
subset: gosubset_prok
synonym: "alpha-D-mannose 1,6-phosphomutase activity" EXACT [EC:5.4.2.8]
synonym: "D-mannose 1,6-phosphomutase activity" EXACT [EC:5.4.2.8]
synonym: "mannose phosphomutase activity" EXACT [EC:5.4.2.8]
synonym: "phosphomannose mutase activity" EXACT [EC:5.4.2.8]
xref: EC:5.4.2.8
xref: MetaCyc:PHOSMANMUT-RXN
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0004616
name: phosphogluconate dehydrogenase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44]
subset: gosubset_prok
synonym: "6-phospho-D-gluconate dehydrogenase activity" EXACT [EC:1.1.1.44]
synonym: "6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.44]
synonym: "6-phosphogluconate dehydrogenase (decarboxylating)" EXACT [EC:1.1.1.44]
synonym: "6-phosphogluconic carboxylase activity" EXACT [EC:1.1.1.44]
synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.44]
synonym: "6PGD activity" EXACT [EC:1.1.1.44]
synonym: "phosphogluconic acid dehydrogenase activity" EXACT [EC:1.1.1.44]
xref: EC:1.1.1.44
xref: MetaCyc:6PGLUCONDEHYDROG-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004617
name: phosphoglycerate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95]
subset: gosubset_prok
synonym: "3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.95]
synonym: "3-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95]
synonym: "3-phosphoglycerate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.95]
synonym: "3-phosphoglyceric acid dehydrogenase activity" EXACT [EC:1.1.1.95]
synonym: "3PHP reductase activity" EXACT [EC:1.1.1.95]
synonym: "alpha-KG reductase activity" EXACT [EC:1.1.1.95]
synonym: "alpha-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95]
synonym: "alphaKG reductase activity" EXACT [EC:1.1.1.95]
synonym: "D- and L-HGA" RELATED [EC:1.1.1.95]
synonym: "D-3-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95]
synonym: "D-3-phosphoglycerate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.95]
synonym: "glycerate 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.95]
synonym: "glycerate-1,3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.95]
synonym: "PGDH activity" EXACT [EC:1.1.1.95]
synonym: "phosphoglycerate oxidoreductase activity" EXACT [EC:1.1.1.95]
synonym: "phosphoglyceric acid dehydrogenase activity" EXACT [EC:1.1.1.95]
synonym: "SerA" RELATED [EC:1.1.1.95]
synonym: "SerA 3PG dehydrogenase activity" EXACT [EC:1.1.1.95]
xref: EC:1.1.1.95
xref: MetaCyc:PGLYCDEHYDROG-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004618
name: phosphoglycerate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate." [EC:2.7.2.3]
subset: gosubset_prok
synonym: "3-PGK" RELATED [EC:2.7.2.3]
synonym: "3-phosphoglycerate kinase activity" EXACT [EC:2.7.2.3]
synonym: "3-phosphoglycerate phosphokinase activity" EXACT [EC:2.7.2.3]
synonym: "3-phosphoglyceric acid kinase activity" EXACT [EC:2.7.2.3]
synonym: "3-phosphoglyceric acid phosphokinase activity" EXACT [EC:2.7.2.3]
synonym: "3-phosphoglyceric kinase activity" EXACT [EC:2.7.2.3]
synonym: "ATP-3-phospho-D-glycerate-1-phosphotransferase activity" EXACT [EC:2.7.2.3]
synonym: "ATP:3-phospho-D-glycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.3]
synonym: "ATP:D-3-phosphoglycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.3]
synonym: "glycerate 3-phosphate kinase activity" EXACT [EC:2.7.2.3]
synonym: "glycerophosphate kinase activity" EXACT [EC:2.7.2.3]
synonym: "PGK" RELATED [EC:2.7.2.3]
synonym: "phosphoglyceric acid kinase activity" EXACT [EC:2.7.2.3]
synonym: "phosphoglyceric kinase activity" EXACT [EC:2.7.2.3]
synonym: "phosphoglycerokinase activity" EXACT [EC:2.7.2.3]
xref: EC:2.7.2.3
xref: MetaCyc:PHOSGLYPHOS-RXN
xref: Reactome:13282 "phosphoglycerate kinase activity"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0004619
name: phosphoglycerate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1]
subset: gosubset_prok
synonym: "bisphosphoglyceromutase" RELATED [EC:5.4.2.1]
synonym: "D-phosphoglycerate 2,3-phosphomutase activity" EXACT [EC:5.4.2.1]
synonym: "diphosphoglycomutase" RELATED [EC:5.4.2.1]
synonym: "GriP mutase" NARROW [EC:5.4.2.1]
synonym: "monophosphoglycerate mutase activity" EXACT [EC:5.4.2.1]
synonym: "monophosphoglyceromutase activity" EXACT [EC:5.4.2.1]
synonym: "MPGM" RELATED [EC:5.4.2.1]
synonym: "PGA mutase activity" EXACT [EC:5.4.2.1]
synonym: "PGAM activity" EXACT [EC:5.4.2.1]
synonym: "PGM" EXACT []
synonym: "phosphoglycerate phosphomutase activity" EXACT [EC:5.4.2.1]
synonym: "phosphoglyceromutase activity" EXACT [EC:5.4.2.1]
xref: EC:5.4.2.1
xref: MetaCyc:3PGAREARR-RXN
xref: Reactome:13285 "phosphoglycerate mutase activity"
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0004620
name: phospholipase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: EC:3.1.1.-
is_a: GO:0016298 ! lipase activity

[Term]
id: GO:0004621
name: glycosylphosphatidylinositol phospholipase D activity
namespace: molecular_function
def: "Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol." [EC:3.1.4.50]
synonym: "glycoprotein phospholipase D activity" EXACT []
synonym: "glycoprotein-phosphatidylinositol phosphatidohydrolase activity" EXACT [EC:3.1.4.50]
synonym: "GPI-PLD activity" EXACT [EC:3.1.4.50]
synonym: "phosphatidylinositol phospholipase D activity" EXACT [EC:3.1.4.50]
synonym: "phosphatidylinositol-glycan-specific phospholipase D activity" EXACT [EC:3.1.4.50]
synonym: "phosphatidylinositol-specific phospholipase D activity" EXACT [EC:3.1.4.50]
xref: EC:3.1.4.50
xref: MetaCyc:GLYCOPROTEIN-PHOSPHOLIPASE-D-RXN
is_a: GO:0004630 ! phospholipase D activity

[Term]
id: GO:0004622
name: lysophospholipase activity
namespace: molecular_function
alt_id: GO:0045126
def: "Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5]
subset: gosubset_prok
synonym: "2-lysophosphatidylcholine acylhydrolase activity" EXACT [EC:3.1.1.5]
synonym: "lecithinase B activity" EXACT [EC:3.1.1.5]
synonym: "lecitholipase activity" EXACT [EC:3.1.1.5]
synonym: "lysolecithinase activity" EXACT [EC:3.1.1.5]
synonym: "lysophopholipase L2" RELATED [EC:3.1.1.5]
synonym: "lysophosphatidase activity" EXACT [EC:3.1.1.5]
synonym: "lysophosphatidylcholine hydrolase activity" EXACT [EC:3.1.1.5]
synonym: "lysophospholipase A1" RELATED [EC:3.1.1.5]
synonym: "phosphatidase B" RELATED [EC:3.1.1.5]
synonym: "phospholipase B activity" EXACT [EC:3.1.1.5]
xref: EC:3.1.1.5
xref: MetaCyc:LYSOPHOSPHOLIPASE-RXN
is_a: GO:0004091 ! carboxylesterase activity
is_a: GO:0004620 ! phospholipase activity

[Term]
id: GO:0004623
name: phospholipase A2 activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]
subset: gosubset_prok
synonym: "cytosolic phospholipase A2 activity" NARROW []
synonym: "lecithinase A activity" EXACT [EC:3.1.1.4]
synonym: "phosphatidase activity" RELATED [EC:3.1.1.4]
synonym: "phosphatidolipase activity" EXACT [EC:3.1.1.4]
synonym: "phosphatidylcholine 2-acylhydrolase activity" EXACT [EC:3.1.1.4]
synonym: "phospholipase A" RELATED [EC:3.1.1.4]
synonym: "secreted phospholipase A2 activity" NARROW []
xref: EC:3.1.1.4
xref: MetaCyc:PHOSPHOLIPASE-A2-RXN
is_a: GO:0004091 ! carboxylesterase activity
is_a: GO:0004620 ! phospholipase activity

[Term]
id: GO:0004624
name: secreted phospholipase A2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4]
comment: This term was made obsolete because it represents component and function information.
is_obsolete: true
replaced_by: GO:0004623
replaced_by: GO:0005576

[Term]
id: GO:0004625
name: calcium-dependent secreted phospholipase A2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4]
comment: This term was made obsolete because it represents component and function information.
is_obsolete: true
replaced_by: GO:0005576
replaced_by: GO:0047498

[Term]
id: GO:0004626
name: cytosolic phospholipase A2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4]
comment: This term was made obsolete because it represents component and function information.
is_obsolete: true
replaced_by: GO:0004623
replaced_by: GO:0005829

[Term]
id: GO:0004627
name: calcium-dependent cytosolic phospholipase A2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4]
comment: This term was made obsolete because it represents component and function information.
is_obsolete: true
replaced_by: GO:0005829
replaced_by: GO:0047498

[Term]
id: GO:0004628
name: calcium-independent cytosolic phospholipase A2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4]
comment: This term was made obsolete because it represents component and function information.
is_obsolete: true
replaced_by: GO:0005829
replaced_by: GO:0047499

[Term]
id: GO:0004629
name: phospholipase C activity
namespace: molecular_function
alt_id: GO:0042298
def: "Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]
subset: gosubset_prok
synonym: "lecithinase C activity" RELATED [EC:3.1.4.3]
synonym: "lipophosphodiesterase C" RELATED [EC:3.1.4.3]
synonym: "phosphatidase C" RELATED [EC:3.1.4.3]
xref: MetaCyc:PHOSPHOLIPASE-C-RXN
xref: Reactome:11457 "phospholipase C activity"
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0004630
name: phospholipase D activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [EC:3.1.4.4]
subset: gosubset_prok
synonym: "choline phosphatase activity" EXACT [EC:3.1.4.4]
synonym: "lecithinase D activity" EXACT [EC:3.1.4.4]
synonym: "lipophosphodiesterase II activity" EXACT [EC:3.1.4.4]
synonym: "phosphatidylcholine phosphatidohydrolase activity" EXACT [EC:3.1.4.4]
xref: EC:3.1.4.4
xref: MetaCyc:PHOSCHOL-RXN
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0004631
name: phosphomevalonate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate." [EC:2.7.4.2]
subset: gosubset_prok
synonym: "5-phosphomevalonate kinase activity" EXACT [EC:2.7.4.2]
synonym: "ATP:(R)-5-phosphomevalonate phosphotransferase activity" EXACT [EC:2.7.4.2]
synonym: "ATP:5-phosphomevalonate phosphotransferase activity" EXACT [EC:2.7.4.2]
synonym: "mevalonate phosphate kinase activity" EXACT [EC:2.7.4.2]
synonym: "mevalonate-5-phosphate kinase activity" EXACT [EC:2.7.4.2]
synonym: "mevalonic acid phosphate kinase activity" EXACT [EC:2.7.4.2]
xref: EC:2.7.4.2
xref: MetaCyc:PHOSPHOMEVALONATE-KINASE-RXN
xref: Reactome:13380 "phosphomevalonate kinase activity"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0004632
name: phosphopantothenate--cysteine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives." [EC:6.3.2.5]
subset: gosubset_prok
synonym: "(R)-4'-phosphopantothenate:L-cysteine ligase activity" EXACT [EC:6.3.2.5]
synonym: "phosphopantothenate-cysteine ligase activity" EXACT []
synonym: "phosphopantothenoylcysteine synthetase activity" EXACT []
xref: EC:6.3.2.5
xref: MetaCyc:P-PANTOCYSLIG-RXN
xref: Reactome:13381 "phosphopantothenate--cysteine ligase activity"
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004633
name: phosphopantothenoylcysteine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-((R)-4-phosphopantothenoyl)-L-cysteine = pantetheine 4'-phosphate + CO2." [EC:4.1.1.36]
subset: gosubset_prok
synonym: "4-phosphopantothenoyl-L-cysteine decarboxylase activity" EXACT [EC:4.1.1.36]
synonym: "4-phosphopantotheoylcysteine decarboxylase activity" EXACT [EC:4.1.1.36]
synonym: "N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.36]
synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)" EXACT [EC:4.1.1.36]
synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.36]
synonym: "PPC-decarboxylase activity" EXACT [EC:4.1.1.36]
xref: EC:4.1.1.36
xref: MetaCyc:P-PANTOCYSDECARB-RXN
xref: Reactome:13382 "phosphopantothenoylcysteine decarboxylase activity"
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004634
name: phosphopyruvate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "14-3-2-protein" RELATED [EC:4.2.1.11]
synonym: "2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)" EXACT [EC:4.2.1.11]
synonym: "2-phospho-D-glycerate hydro-lyase activity" EXACT [EC:4.2.1.11]
synonym: "2-phospho-D-glycerate-hydrolase activity" EXACT []
synonym: "2-phosphoglycerate dehydratase activity" EXACT [EC:4.2.1.11]
synonym: "2-phosphoglycerate enolase activity" EXACT [EC:4.2.1.11]
synonym: "2-phosphoglyceric dehydratase activity" EXACT [EC:4.2.1.11]
synonym: "enolase activity" EXACT [EC:4.2.1.11]
synonym: "gamma-enolase activity" EXACT [EC:4.2.1.11]
synonym: "nervous-system specific enolase" NARROW [EC:4.2.1.11]
synonym: "phosphoenolpyruvate hydratase activity" EXACT [EC:4.2.1.11]
xref: EC:4.2.1.11
xref: MetaCyc:2PGADEHYDRAT-RXN
xref: Reactome:13384 "phosphopyruvate hydratase activity"
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004635
name: phosphoribosyl-AMP cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide." [EC:3.5.4.19]
subset: gosubset_prok
synonym: "1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity" EXACT [EC:3.5.4.19]
synonym: "phosphoribosyladenosine monophosphate cyclohydrolase activity" EXACT [EC:3.5.4.19]
synonym: "PRAMP-cyclohydrolase activity" EXACT [EC:3.5.4.19]
xref: EC:3.5.4.19
xref: MetaCyc:HISTCYCLOHYD-RXN
is_a: GO:0019238 ! cyclohydrolase activity

[Term]
id: GO:0004636
name: phosphoribosyl-ATP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-phosphoribosyl-ATP + H2O = 5-phosphoribosyl-AMP + diphosphate." [EC:3.6.1.31]
subset: gosubset_prok
synonym: "1-(5-phosphoribosyl)-ATP diphosphohydrolase activity" EXACT [EC:3.6.1.31]
synonym: "phosphoribosyl-ATP pyrophosphatase activity" EXACT []
synonym: "phosphoribosyladenosine triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.31]
xref: EC:3.6.1.31
xref: MetaCyc:HISTPRATPHYD-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0004637
name: phosphoribosylamine-glycine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide." [EC:6.3.4.13]
subset: gosubset_prok
synonym: "2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity" EXACT [EC:6.3.4.13]
synonym: "5'-phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13]
synonym: "5-phospho-D-ribosylamine:glycine ligase (ADP-forming)" EXACT [EC:6.3.4.13]
synonym: "GAR" RELATED [EC:6.3.4.13]
synonym: "GAR synthetase activity" EXACT [EC:6.3.4.13]
synonym: "GARS activity" EXACT [EC:6.3.4.13]
synonym: "glycinamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13]
synonym: "glycineamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13]
synonym: "phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13]
synonym: "phosphoribosylglycineamide synthetase activity" EXACT [EC:6.3.4.13]
xref: EC:6.3.4.13
xref: MetaCyc:GLYRIBONUCSYN-RXN
xref: Reactome:13392 "phosphoribosylamine-glycine ligase activity"
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004638
name: phosphoribosylaminoimidazole carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2." [EC:4.1.1.21]
subset: gosubset_prok
synonym: "1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.21]
synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]" RELATED [EC:4.1.1.21]
synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity" EXACT [EC:4.1.1.21]
synonym: "5-amino-1-ribosylimidazole 5-phosphate carboxylase activity" EXACT [EC:4.1.1.21]
synonym: "5-phosphoribosyl-5-aminoimidazole carboxylase activity" EXACT [EC:4.1.1.21]
synonym: "ADE2" RELATED [EC:4.1.1.21]
synonym: "AIR carboxylase activity" EXACT [EC:4.1.1.21]
synonym: "class II PurE" RELATED [EC:4.1.1.21]
xref: EC:4.1.1.21
xref: MetaCyc:AIRCARBOXY-RXN
xref: Reactome:13396 "phosphoribosylaminoimidazole carboxylase activity"
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004639
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate." [EC:6.3.2.6]
subset: gosubset_prok
synonym: "4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.2.6]
synonym: "4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity" EXACT [EC:6.3.2.6]
synonym: "4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.2.6]
synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)" EXACT [EC:6.3.2.6]
synonym: "5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity" EXACT [EC:6.3.2.6]
synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthase activity" EXACT [EC:6.3.2.6]
synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthetase activity" EXACT [EC:6.3.2.6]
synonym: "phosphoribosylaminoimidazolesuccinocarboxamide synthetase activity" EXACT [EC:6.3.2.6]
synonym: "PurC" RELATED [EC:6.3.2.6]
synonym: "SAICAR synthase activity" EXACT [EC:6.3.2.6]
synonym: "SAICAR synthetase activity" EXACT [EC:6.3.2.6]
synonym: "SAICARs activity" EXACT [EC:6.3.2.6]
xref: EC:6.3.2.6
xref: MetaCyc:SAICARSYN-RXN
xref: Reactome:13398 "phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004640
name: phosphoribosylanthranilate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)-anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate." [EC:5.3.1.24]
subset: gosubset_prok
synonym: "IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)" RELATED [EC:5.3.1.24]
synonym: "N-(5'-phosphoribosyl)anthranilate isomerase activity" EXACT [EC:5.3.1.24]
synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.24]
synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity" EXACT [EC:5.3.1.24]
synonym: "PRA isomerase activity" EXACT [EC:5.3.1.24]
synonym: "PRAI activity" EXACT [EC:5.3.1.24]
xref: EC:5.3.1.24
xref: MetaCyc:PRAISOM-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004641
name: phosphoribosylformylglycinamidine cyclo-ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole." [EC:6.3.3.1]
subset: gosubset_prok
synonym: "2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1]
synonym: "2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1]
synonym: "5'-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.3.1]
synonym: "AIR synthase activity" EXACT [EC:6.3.3.1]
synonym: "AIR synthetase activity" EXACT [EC:6.3.3.1]
synonym: "AIRS activity" EXACT [EC:6.3.3.1]
synonym: "phosphoribosyl-aminoimidazole synthetase activity" EXACT [EC:6.3.3.1]
synonym: "phosphoribosylaminoimidazole synthetase activity" EXACT [EC:6.3.3.1]
xref: EC:6.3.3.1
xref: MetaCyc:AIRS-RXN
xref: Reactome:13434 "phosphoribosylformylglycinamidine cyclo-ligase activity"
is_a: GO:0016882 ! cyclo-ligase activity

[Term]
id: GO:0004642
name: phosphoribosylformylglycinamidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5'-phosphoribosylformylglycinamide + L-glutamine + H2O = ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-glutamate." [EC:6.3.5.3]
subset: gosubset_prok
synonym: "2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3]
synonym: "5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3]
synonym: "FGAM synthase activity" EXACT [EC:6.3.5.3]
synonym: "FGAM synthetase activity" EXACT [EC:6.3.5.3]
synonym: "FGAR amidotransferase activity" EXACT [EC:6.3.5.3]
synonym: "FGARAT activity" EXACT [EC:6.3.5.3]
synonym: "formylglycinamide ribonucloetide amidotransferase activity" EXACT [EC:6.3.5.3]
synonym: "formylglycinamide ribotide amidotransferase activity" EXACT [EC:6.3.5.3]
synonym: "N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3]
synonym: "phosphoribosylformylglycinamidine synthetase activity" EXACT [EC:6.3.5.3]
synonym: "phosphoribosylformylglycineamidine synthetase activity" EXACT [EC:6.3.5.3]
xref: EC:6.3.5.3
xref: MetaCyc:FGAMSYN-RXN
xref: Reactome:13437 "phosphoribosylformylglycinamidine synthase activity"
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0004643
name: phosphoribosylaminoimidazolecarboxamide formyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide." [EC:2.1.2.3]
subset: gosubset_prok
synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity" EXACT [EC:2.1.2.3]
synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3]
synonym: "5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3]
synonym: "5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.3]
synonym: "5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3]
synonym: "5-amino-4-imidazolecarboxamide ribotide transformylase activity" EXACT [EC:2.1.2.3]
synonym: "AICAR formyltransferase activity" EXACT [EC:2.1.2.3]
synonym: "AICAR transformylase activity" EXACT [EC:2.1.2.3]
synonym: "aminoimidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3]
xref: EC:2.1.2.3
xref: MetaCyc:AICARTRANSFORM-RXN
xref: Reactome:13439 "phosphoribosylaminoimidazolecarboxamide formyltransferase activity"
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0004644
name: phosphoribosylglycinamide formyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide." [EC:2.1.2.2]
subset: gosubset_prok
synonym: "10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase activity" EXACT [EC:2.1.2.2]
synonym: "2-amino-N-ribosylacetamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.2]
synonym: "5'-phosphoribosylglycinamide transformylase activity" EXACT [EC:2.1.2.2]
synonym: "5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.2]
synonym: "GAR formyltransferase activity" EXACT [EC:2.1.2.2]
synonym: "GAR TFase activity" EXACT [EC:2.1.2.2]
synonym: "GAR transformylase activity" EXACT [EC:2.1.2.2]
synonym: "GART activity" EXACT [EC:2.1.2.2]
synonym: "glycinamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.2]
xref: EC:2.1.2.2
xref: MetaCyc:GART-RXN
xref: Reactome:13440 "phosphoribosylglycinamide formyltransferase activity"
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0004645
name: phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase." [EC:2.4.1.1]
subset: gosubset_prok
synonym: "1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.1]
synonym: "1,4-alpha-glucan phosphorylase activity" EXACT [EC:2.4.1.1]
synonym: "alpha-glucan phosphorylase" BROAD [EC:2.4.1.1]
synonym: "amylopectin phosphorylase" NARROW [EC:2.4.1.1]
synonym: "amylophosphorylase activity" NARROW [EC:2.4.1.1]
synonym: "glucan phosphorylase" NARROW [EC:2.4.1.1]
synonym: "glucosan phosphorylase" NARROW [EC:2.4.1.1]
synonym: "granulose phosphorylase" NARROW [EC:2.4.1.1]
synonym: "muscle phosphorylase" NARROW [EC:2.4.1.1]
synonym: "muscle phosphorylase a and b activity" NARROW [EC:2.4.1.1]
synonym: "myophosphorylase" NARROW [EC:2.4.1.1]
synonym: "polyphosphorylase activity" EXACT [EC:2.4.1.1]
synonym: "potato phosphorylase" NARROW [EC:2.4.1.1]
synonym: "starch phosphorylase" NARROW [EC:2.4.1.1]
xref: EC:2.4.1.1
xref: MetaCyc:RXN-1826
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0004647
name: phosphoserine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate." [EC:3.1.3.3]
subset: gosubset_prok
synonym: "O-phosphoserine phosphohydrolase activity" EXACT [EC:3.1.3.3]
xref: EC:3.1.3.3
xref: MetaCyc:PSERPHOSPHA-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0004648
name: O-phospho-L-serine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
alt_id: GO:0004646
def: "Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate." [EC:2.6.1.52]
subset: gosubset_prok
synonym: "3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.52]
synonym: "3-phosphoserine aminotransferase activity" EXACT [EC:2.6.1.52]
synonym: "3PHP transaminase activity" EXACT [EC:2.6.1.52]
synonym: "hydroxypyruvic phosphate--glutamic transaminase activity" EXACT [EC:2.6.1.52]
synonym: "L-phosphoserine aminotransferase activity" EXACT [EC:2.6.1.52]
synonym: "PdxC" RELATED [EC:2.6.1.52]
synonym: "phosphohydroxypyruvate transaminase activity" EXACT [EC:2.6.1.52]
synonym: "phosphohydroxypyruvic--glutamic transaminase activity" EXACT [EC:2.6.1.52]
synonym: "phosphoserine aminotransferase activity" BROAD []
synonym: "phosphoserine transaminase activity" BROAD [EC:2.6.1.52]
synonym: "PSAT activity" EXACT [EC:2.6.1.52]
synonym: "SerC" RELATED [EC:2.6.1.52]
xref: EC:2.6.1.52
xref: MetaCyc:PSERTRANSAM-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004649
name: poly(ADP-ribose) glycohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143]
xref: EC:3.2.1.143
xref: MetaCyc:3.2.1.143-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004650
name: polygalacturonase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans." [EC:3.2.1.15]
subset: gosubset_prok
synonym: "endo-D-galacturonase activity" EXACT []
synonym: "endo-polygalacturonase activity" EXACT []
synonym: "endogalacturonase activity" EXACT []
synonym: "endopolygalacturonase activity" EXACT []
synonym: "pectin depolymerase activity" NARROW [EC:3.2.1.15]
synonym: "pectin hydrolase activity" EXACT [EC:3.2.1.15]
synonym: "pectin polygalacturonase activity" EXACT [EC:3.2.1.15]
synonym: "pectinase activity" NARROW [EC:3.2.1.15]
synonym: "pectolase activity" EXACT [EC:3.2.1.15]
synonym: "poly(1,4-alpha-D-galacturonide) glycanohydrolase activity" EXACT []
synonym: "poly-alpha-1,4-galacturonide glycanohydrolase activity" EXACT []
xref: EC:3.2.1.15
xref: MetaCyc:RXN-2103
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0004651
name: polynucleotide 5'-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [EC:3.1.3.33]
synonym: "5'-polynucleotidase activity" EXACT [EC:3.1.3.33]
synonym: "polynucleotide 5'-phosphohydrolase activity" EXACT [EC:3.1.3.33]
synonym: "polynucleotide 5'-triphosphatase activity" EXACT [EC:3.1.3.33]
xref: EC:3.1.3.33
xref: MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN
xref: Reactome:13463 "polynucleotide 5'-phosphatase activity"
is_a: GO:0019204 ! nucleotide phosphatase activity

[Term]
id: GO:0004652
name: polynucleotide adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [EC:2.7.7.19]
subset: gosubset_prok
synonym: "adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [EC:2.7.7.19]
synonym: "AMP polynucleotidylexotransferase activity" EXACT [EC:2.7.7.19]
synonym: "ATP-polynucleotide adenylyltransferase activity" EXACT [EC:2.7.7.19]
synonym: "ATP:polynucleotide adenylyltransferase activity" EXACT [EC:2.7.7.19]
synonym: "ATP:polynucleotidylexotransferase activity" EXACT [EC:2.7.7.19]
synonym: "NTP polymerase activity" EXACT [EC:2.7.7.19]
synonym: "poly(A) hydrolase activity" EXACT [EC:2.7.7.19]
synonym: "poly(A) polymerase activity" EXACT [EC:2.7.7.19]
synonym: "poly(A) synthetase activity" EXACT [EC:2.7.7.19]
synonym: "poly-A polymerase activity" EXACT [EC:2.7.7.19]
synonym: "polyadenylate nucleotidyltransferase activity" EXACT [EC:2.7.7.19]
synonym: "polyadenylate polymerase activity" EXACT [EC:2.7.7.19]
synonym: "polyadenylate synthetase activity" EXACT [EC:2.7.7.19]
synonym: "polyadenylic acid polymerase activity" EXACT [EC:2.7.7.19]
synonym: "polyadenylic polymerase activity" EXACT [EC:2.7.7.19]
synonym: "RNA adenylating enzyme activity" EXACT [EC:2.7.7.19]
synonym: "RNA formation factors, PF1" RELATED [EC:2.7.7.19]
synonym: "terminal riboadenylate transferase activity" EXACT [EC:2.7.7.19]
xref: EC:2.7.7.19
xref: MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN
xref: Reactome:72182 "polynucleotide adenylyltransferase activity"
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0004653
name: polypeptide N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. Catalyzes of the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595]
synonym: "glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "polypeptide-N-acetylgalactosamine transferase activity" EXACT [EC:2.4.1.41]
synonym: "protein-UDP acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
synonym: "UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity" EXACT [EC:2.4.1.41]
synonym: "uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41]
xref: EC:2.4.1.41
xref: MetaCyc:2.4.1.41-RXN
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0004654
name: polyribonucleotide nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.8]
subset: gosubset_prok
synonym: "nucleoside diphosphate:polynucleotidyl transferase activity" EXACT [EC:2.7.7.8]
synonym: "polynucleotide phosphorylase activity" EXACT [EC:2.7.7.8]
synonym: "polyribonucleotide phosphorylase activity" EXACT [EC:2.7.7.8]
synonym: "polyribonucleotide:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.8]
xref: EC:2.7.7.8
xref: MetaCyc:2.7.7.8-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0004655
name: porphobilinogen synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O." [EC:4.2.1.24]
subset: gosubset_prok
synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)" EXACT [EC:4.2.1.24]
synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)" EXACT [EC:4.2.1.24]
synonym: "5-levulinic acid dehydratase activity" EXACT [EC:4.2.1.24]
synonym: "aminolevulinate dehydratase activity" EXACT []
synonym: "aminolevulinic dehydratase activity" EXACT [EC:4.2.1.24]
synonym: "delta-aminolevulinate dehydratase activity" EXACT [EC:4.2.1.24]
synonym: "delta-aminolevulinic acid dehydrase activity" EXACT [EC:4.2.1.24]
synonym: "delta-aminolevulinic acid dehydratase activity" EXACT []
synonym: "delta-aminolevulinic dehydratase activity" EXACT [EC:4.2.1.24]
xref: EC:4.2.1.24
xref: MetaCyc:PORPHOBILSYNTH-RXN
xref: Reactome:13469 "porphobilinogen synthase activity"
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004656
name: procollagen-proline 4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2]
synonym: "collagen proline hydroxylase activity" EXACT [EC:1.14.11.2]
synonym: "hydroxylase, collagen proline activity" EXACT [EC:1.14.11.2]
synonym: "peptidyl proline hydroxylase activity" EXACT [EC:1.14.11.2]
synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity" EXACT [EC:1.14.11.2]
synonym: "procollagen-proline,2-oxoglutarate-4-dioxygenase activity" EXACT []
synonym: "proline hydroxylase activity" BROAD [EC:1.14.11.2]
synonym: "proline protocollagen hydroxylase activity" EXACT [EC:1.14.11.2]
synonym: "proline, 2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.2]
synonym: "proline,2-oxoglutarate 4-dioxygenase activity" BROAD [EC:1.14.11.2]
synonym: "prolyl 4-hydroxylase activity" BROAD [EC:1.14.11.2]
synonym: "prolyl hydroxylase activity" BROAD [EC:1.14.11.2]
synonym: "prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity" EXACT [EC:1.14.11.2]
synonym: "prolylprotocollagen dioxygenase activity" EXACT [EC:1.14.11.2]
synonym: "prolylprotocollagen hydroxylase activity" EXACT [EC:1.14.11.2]
synonym: "protocollagen hydroxylase activity" BROAD [EC:1.14.11.2]
synonym: "protocollagen proline 4-hydroxylase activity" EXACT [EC:1.14.11.2]
synonym: "protocollagen proline dioxygenase activity" EXACT [EC:1.14.11.2]
synonym: "protocollagen proline hydroxylase activity" EXACT [EC:1.14.11.2]
synonym: "protocollagen prolyl hydroxylase activity" EXACT [EC:1.14.11.2]
xref: EC:1.14.11.2
xref: MetaCyc:1.14.11.2-RXN
is_a: GO:0019798 ! procollagen-proline dioxygenase activity
is_a: GO:0031545 ! peptidyl-proline 4-dioxygenase activity

[Term]
id: GO:0004657
name: proline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8]
subset: gosubset_prok
synonym: "L-proline dehydrogenase activity" EXACT [EC:1.5.99.8]
synonym: "L-proline:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.8]
synonym: "L-proline:acceptor oxidoreductase activity" EXACT [EC:1.5.99.8]
xref: EC:1.5.99.8
xref: MetaCyc:RXN-7181
xref: Reactome:13472 "proline dehydrogenase activity"
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0004658
name: propionyl-CoA carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." [EC:6.4.1.3]
subset: gosubset_prok
synonym: "PCCase activity" EXACT [EC:6.4.1.3]
synonym: "propanoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.3]
synonym: "propionyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.3]
xref: EC:6.4.1.3
xref: MetaCyc:PROPIONYL-COA-CARBOXY-RXN
xref: Reactome:13473 "propionyl-CoA carboxylase activity"
is_a: GO:0016421 ! CoA carboxylase activity

[Term]
id: GO:0004659
name: prenyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]
subset: gosubset_prok
xref: EC:2.5.1.-
xref: MetaCyc:GPPSYN-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004660
name: protein farnesyltransferase activity
namespace: molecular_function
alt_id: GO:0018223
def: "Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate." [EC:2.5.1.58, PMID:8621375]
synonym: "CAAX farnesyltransferase activity" NARROW [EC:2.5.1.58]
synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase activity" EXACT [EC:2.5.1.58]
synonym: "FTase activity" EXACT [EC:2.5.1.58]
synonym: "protein-cysteine farnesyltransferase activity" EXACT []
xref: EC:2.5.1.58
xref: MetaCyc:2.5.1.58-RXN
is_a: GO:0008318 ! protein prenyltransferase activity

[Term]
id: GO:0004661
name: protein geranylgeranyltransferase activity
namespace: molecular_function
alt_id: GO:0018224
def: "Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein." [PMID:8621375]
synonym: "protein-cysteine geranylgeranyltransferase activity" EXACT []
xref: EC:2.5.1.-
is_a: GO:0008318 ! protein prenyltransferase activity

[Term]
id: GO:0004662
name: CAAX-protein geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375]
synonym: "geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT []
synonym: "geranylgeranyltransferase type I activity" EXACT []
synonym: "GGTase-I activity" EXACT []
synonym: "GGTaseI activity" EXACT []
synonym: "protein geranylgeranyltransferase type I" RELATED [EC:2.5.1.59]
synonym: "type I protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.59]
xref: EC:2.5.1.59
xref: MetaCyc:2.5.1.60-RXN
xref: MetaCyc:RXN-3701
is_a: GO:0004661 ! protein geranylgeranyltransferase activity

[Term]
id: GO:0004663
name: Rab geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375]
synonym: "geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT []
synonym: "GGTase-II activity" EXACT []
synonym: "GGTaseII activity" EXACT []
synonym: "protein geranylgeranyltransferase type II activity" EXACT []
synonym: "Rab-protein geranylgeranyltransferase activity" EXACT []
synonym: "RabGGTase activity" EXACT []
synonym: "type II protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.60]
xref: EC:2.5.1.60
xref: MetaCyc:2.5.1.60-RXN
xref: MetaCyc:RXN-3701
is_a: GO:0004661 ! protein geranylgeranyltransferase activity

[Term]
id: GO:0004664
name: prephenate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2." [EC:4.2.1.51]
subset: gosubset_prok
synonym: "prephenate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.51]
synonym: "prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)" EXACT [EC:4.2.1.51]
xref: EC:4.2.1.51
xref: MetaCyc:PREPHENATEDEHYDRAT-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004665
name: prephenate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH + H+." [EC:1.3.1.13]
subset: gosubset_prok
synonym: "prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.3.1.13]
synonym: "prephenate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.13]
xref: EC:1.3.1.13
xref: MetaCyc:PREPHENATE-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004666
name: prostaglandin-endoperoxide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [EC:1.14.99.1]
synonym: "(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.1]
synonym: "(PG)H synthase activity" EXACT [EC:1.14.99.1]
synonym: "fatty acid cyclooxygenase activity" EXACT [EC:1.14.99.1]
synonym: "PG synthetase activity" EXACT [EC:1.14.99.1]
synonym: "prostaglandin endoperoxide synthetase activity" EXACT [EC:1.14.99.1]
synonym: "prostaglandin G/H synthase activity" EXACT [EC:1.14.99.1]
synonym: "prostaglandin synthase activity" EXACT [EC:1.14.99.1]
synonym: "prostaglandin synthetase activity" EXACT [EC:1.14.99.1]
xref: EC:1.14.99.1
xref: MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN
xref: Reactome:13496 "prostaglandin-endoperoxide synthase activity"
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0004667
name: prostaglandin-D synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate." [EC:5.3.99.2]
synonym: "(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity" EXACT [EC:5.3.99.2]
synonym: "PGD2 synthase activity" EXACT [EC:5.3.99.2]
synonym: "PGH-PGD isomerase activity" EXACT [EC:5.3.99.2]
synonym: "prostaglandin D2 synthase activity" EXACT [EC:5.3.99.2]
synonym: "prostaglandin-H2 D-isomerase activity" EXACT [EC:5.3.99.2]
synonym: "prostaglandin-R-prostaglandin D isomerase activity" EXACT [EC:5.3.99.2]
xref: EC:5.3.99.2
xref: MetaCyc:PROSTAGLANDIN-D-SYNTHASE-RXN
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0004668
name: protein-arginine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3." [EC:3.5.3.15]
subset: gosubset_prok
synonym: "peptidylarginine deiminase activity" EXACT [EC:3.5.3.15]
synonym: "protein-L-arginine iminohydrolase activity" EXACT [EC:3.5.3.15]
xref: EC:3.5.3.15
xref: MetaCyc:PROTEIN-ARGININE-DEIMINASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0004671
name: protein-S-isoprenylcysteine O-methyltransferase activity
namespace: molecular_function
alt_id: GO:0018225
def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester." [EC:2.1.1.100]
subset: gosubset_prok
synonym: "farnesyl cysteine C-terminal methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "farnesyl-protein carboxymethyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "farnesylated protein C-terminal O-methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "isoprenylated protein methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "isoprenylcysteine carboxylmethyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "prenylated protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "prenylated protein methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "prenylcysteine carboxyl methyltransferase activity" RELATED [EC:2.1.1.100]
synonym: "prenylcysteine carboxylmethyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "prenylcysteine carboxymethyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "prenylcysteine methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "protein C-terminal farnesylcysteine O-methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "protein S-farnesylcysteine C-terminal methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity" EXACT [EC:2.1.1.100]
synonym: "S-farnesylcysteine methyltransferase activity" EXACT [EC:2.1.1.100]
xref: EC:2.1.1.100
xref: MetaCyc:2.1.1.100-RXN
is_a: GO:0003880 ! C-terminal protein carboxyl methyltransferase activity
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004672
name: protein kinase activity
namespace: molecular_function
alt_id: GO:0050222
def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]
comment: Note that triphosphate is used as a phosphate donor by at least one kinase.
subset: goslim_candida
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
synonym: "protamine kinase activity" NARROW []
xref: MetaCyc:PROTEIN-KINASE-RXN
xref: Reactome:4030 "protein kinase activity"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004673
name: protein histidine kinase activity
namespace: molecular_function
alt_id: GO:0008896
def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine." [EC:2.7.13.3, GOC:mah]
subset: gosubset_prok
synonym: "ATP:protein-L-histidine N-phosphotransferase activity" EXACT [EC:2.7.13.3]
synonym: "EnvZ" NARROW [EC:2.7.13.3]
synonym: "histidine kinase (ambiguous)" EXACT [EC:2.7.13.3]
synonym: "histidine kinase activity" EXACT []
synonym: "histidine protein kinase (ambiguous)" EXACT [EC:2.7.13.3]
synonym: "histidine protein kinase activity" EXACT [EC:2.7.13.3]
synonym: "HK1" RELATED [EC:2.7.13.3]
synonym: "HP165" RELATED [EC:2.7.13.3]
synonym: "protein histidine kinase (ambiguous)" EXACT [EC:2.7.13.3]
synonym: "protein kinase (histidine)" EXACT [EC:2.7.13.3]
synonym: "protein kinase (histidine) (ambiguous)" EXACT [EC:2.7.13.3]
synonym: "protein-histidine kinase activity" EXACT []
synonym: "Sln1p" NARROW [EC:2.7.13.3]
xref: EC:2.7.13.3
xref: MetaCyc:2.7.13.3-RXN
is_a: GO:0004672 ! protein kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0004674
name: protein serine/threonine kinase activity
namespace: molecular_function
alt_id: GO:0004700
def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate." [GOC:bf]
subset: gosubset_prok
synonym: "A-kinase activity" NARROW [EC:2.7.11.1]
synonym: "AP50 kinase activity" NARROW [EC:2.7.11.1]
synonym: "ATP-protein transphosphorylase activity" NARROW [EC:2.7.11.1]
synonym: "ATP:protein phosphotransferase (non-specific) activity" NARROW [EC:2.7.11.1]
synonym: "atypical PKC activity" NARROW []
synonym: "atypical protein kinase C activity" NARROW []
synonym: "betaIIPKC" RELATED [EC:2.7.11.1]
synonym: "calcium/phospholipid-dependent protein kinase activity" NARROW [EC:2.7.11.1]
synonym: "casein kinase (phosphorylating) activity" NARROW [EC:2.7.11.1]
synonym: "cytidine 3',5'-cyclic monophosphate-responsive protein kinase activity" NARROW [EC:2.7.11.1]
synonym: "dsk1" RELATED [EC:2.7.11.1]
synonym: "epsilon PKC" RELATED [EC:2.7.11.1]
synonym: "glycogen synthase a kinase activity" NARROW [EC:2.7.11.1]
synonym: "glycogen synthase A kinase activity" NARROW [EC:2.7.11.1]
synonym: "glycogen synthase kinase activity" NARROW [EC:2.7.11.1]
synonym: "HIPK2" RELATED [EC:2.7.11.1]
synonym: "Hpr kinase activity" NARROW [EC:2.7.11.1]
synonym: "hydroxyalkyl-protein kinase activity" NARROW [EC:2.7.11.1]
synonym: "M phase-specific cdc2 kinase activity" NARROW [EC:2.7.11.1]
synonym: "MAPK" RELATED [EC:2.7.11.1]
synonym: "mitogen-activated protein kinase activity" BROAD [EC:2.7.11.1]
synonym: "mitogen-activated S6 kinase activity" NARROW [EC:2.7.11.1]
synonym: "non-specific serine/threonine protein kinase activity" NARROW [EC:2.7.11.1]
synonym: "p82 kinase activity" NARROW [EC:2.7.11.1]
synonym: "phosphorylase B kinase kinase activity" NARROW [EC:2.7.11.1]
synonym: "phosphorylase b kinase kinase activity" BROAD [EC:2.7.11.1]
synonym: "PKA" RELATED [EC:2.7.11.1]
synonym: "PKC" RELATED [EC:2.7.11.1]
synonym: "protein glutamyl kinase activity" NARROW [EC:2.7.11.1]
synonym: "protein kinase (phosphorylating) activity" NARROW [EC:2.7.11.1]
synonym: "protein kinase A activity" BROAD [EC:2.7.11.1]
synonym: "protein kinase p58 activity" NARROW [EC:2.7.11.1]
synonym: "protein phosphokinase activity" NARROW [EC:2.7.11.1]
synonym: "protein serine kinase activity" NARROW [EC:2.7.11.1]
synonym: "protein serine-threonine kinase activity" EXACT [EC:2.7.11.1]
synonym: "protein-aspartyl kinase activity" RELATED [EC:2.7.11.1]
synonym: "protein-cysteine kinase activity" NARROW [EC:2.7.11.1]
synonym: "protein-serine kinase activity" NARROW [EC:2.7.11.1]
synonym: "Prp4 protein kinase activity" NARROW [EC:2.7.11.1]
synonym: "Raf kinase activity" NARROW [EC:2.7.11.1]
synonym: "Raf-1" RELATED [EC:2.7.11.1]
synonym: "ribosomal protein S6 kinase II activity" NARROW [EC:2.7.11.1]
synonym: "ribosomal S6 protein kinase activity" NARROW [EC:2.7.11.1]
synonym: "serine kinase activity" NARROW [EC:2.7.11.1]
synonym: "serine protein kinase activity" NARROW [EC:2.7.11.1]
synonym: "serine(threonine) protein kinase activity" EXACT [EC:2.7.11.1]
synonym: "serine-specific protein kinase activity" NARROW [EC:2.7.11.1]
synonym: "serine/threonine protein kinase activity" EXACT [EC:2.7.11.1]
synonym: "STK32" RELATED [EC:2.7.11.1]
synonym: "T-antigen kinase activity" NARROW [EC:2.7.11.1]
synonym: "threonine-specific protein kinase activity" NARROW [EC:2.7.11.1]
synonym: "twitchin kinase activity" NARROW [EC:2.7.11.1]
synonym: "Wee 1-like kinase activity" NARROW [EC:2.7.11.1]
synonym: "Wee-kinase activity" NARROW [EC:2.7.11.1]
synonym: "WEE1Hu" RELATED [EC:2.7.11.1]
xref: EC:2.7.11
xref: EC:2.7.11.-
xref: MetaCyc:PROTEIN-KINASE-RXN
xref: Reactome:4028 "protein serine/threonine kinase activity"
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0004675
name: transmembrane receptor protein serine/threonine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + receptor-protein serine/threonine = ADP + receptor-protein serine/threonine phosphate." [EC:2.7.11.30]
synonym: "activin receptor kinase activity" NARROW [EC:2.7.11.30]
synonym: "ATP:receptor-protein phosphotransferase activity" EXACT [EC:2.7.11.30]
synonym: "receptor protein serine/threonine kinase activity" EXACT [EC:2.7.11.30]
synonym: "receptor serine/threonine protein kinase activity" EXACT [EC:2.7.11.30]
synonym: "receptor type I serine/threonine protein kinase activity" NARROW [EC:2.7.11.30]
synonym: "receptor type II serine/threonine protein kinase activity" NARROW [EC:2.7.11.30]
synonym: "STK13" RELATED [EC:2.7.11.30]
synonym: "TGF-beta kinase activity" NARROW [EC:2.7.11.30]
xref: EC:2.7.11.-
xref: MetaCyc:2.7.11.30-RXN
xref: Reactome:11160 "transmembrane receptor protein serine/threonine kinase activity"
is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity
is_a: GO:0019199 ! transmembrane receptor protein kinase activity

[Term]
id: GO:0004676
name: 3-phosphoinositide-dependent protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of a 3-phosphoinositide." [GOC:mah]
xref: EC:2.7.11.-
xref: Reactome:13519 "3-phosphoinositide-dependent protein kinase activity"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004677
name: DNA-dependent protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, requiring the presence of DNA." [GOC:mah]
xref: EC:2.7.11.-
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004679
name: AMP-activated protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of AMP." [GOC:mah]
synonym: "5'-AMP-activated protein kinase activity" EXACT []
synonym: "SNF1A/AMP-activated protein kinase activity" NARROW []
xref: EC:2.7.11.-
xref: Reactome:13522 "AMP-activated protein kinase activity"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004680
name: casein kinase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
xref: EC:2.7.11.-
is_obsolete: true
replaced_by: GO:0004674

[Term]
id: GO:0004681
name: casein kinase I activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
xref: EC:2.7.11.-
is_obsolete: true
replaced_by: GO:0004674

[Term]
id: GO:0004682
name: protein kinase CK2 activity
namespace: molecular_function
alt_id: GO:0008604
def: "OBSOLETE. Catalysis of the reaction: casein + ATP = phosphocasein + ADP." [EC:2.7.11.1]
comment: This term was made obsolete because it represents a gene product.
synonym: "casein kinase II activity" RELATED []
synonym: "casein kinase II, catalytic activity" EXACT []
synonym: "protein kinase CK2, intrinsic catalyst activity" EXACT []
is_obsolete: true
replaced_by: GO:0004674

[Term]
id: GO:0004683
name: calmodulin-dependent protein kinase activity
namespace: molecular_function
alt_id: GO:0004684
alt_id: GO:0004685
alt_id: GO:0004688
def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]
subset: gosubset_prok
synonym: "ATP:caldesmon O-phosphotransferase activity" NARROW [EC:2.7.11.17]
synonym: "ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity" EXACT [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase 1 activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase activity" EXACT [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase II activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase IV activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase kinase activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/calmodulin-dependent protein kinase kinase beta activity" NARROW [EC:2.7.11.17]
synonym: "Ca2+/CaM-dependent kinase activity" EXACT []
synonym: "calcium- and calmodulin-dependent protein kinase activity" EXACT []
synonym: "calcium/calmodulin-dependent protein kinase activity" EXACT [EC:2.7.11.17]
synonym: "calcium/calmodulin-dependent protein kinase type II activity" NARROW [EC:2.7.11.17]
synonym: "caldesmon kinase (phosphorylating) activity" NARROW [EC:2.7.11.17]
synonym: "calmodulin regulated protein kinase activity" EXACT []
synonym: "calmodulin-dependent kinase II activity" NARROW [EC:2.7.11.17]
synonym: "calmodulin-dependent protein kinase I activity" NARROW []
synonym: "CaM kinase activity" EXACT [EC:2.7.11.17]
synonym: "CaM kinase II activity" NARROW [EC:2.7.11.17]
synonym: "CAM PKII" RELATED [EC:2.7.11.17]
synonym: "CaM-regulated serine/threonine kinase activity" EXACT [EC:2.7.11.17]
synonym: "CaMKI" RELATED [EC:2.7.11.17]
synonym: "CaMKII" RELATED [EC:2.7.11.17]
synonym: "CaMKIV" RELATED [EC:2.7.11.17]
synonym: "CaMKKalpha" RELATED [EC:2.7.11.17]
synonym: "CaMKKbeta" RELATED [EC:2.7.11.17]
synonym: "microtubule-associated protein 2 kinase activity" RELATED [EC:2.7.11.17]
synonym: "multifunctional calcium- and calmodulin-regulated protein kinase activity" RELATED []
synonym: "multifunctional calcium/calmodulin regulated protein kinase activity" RELATED []
synonym: "STK20" RELATED [EC:2.7.11.17]
xref: EC:2.7.11.17
xref: MetaCyc:2.7.11.17-RXN
xref: Reactome:4026 "calmodulin-dependent protein kinase activity"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004686
name: elongation factor-2 kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of eukaryotic elongation factor-2." [GOC:jl, PMID:11904175]
synonym: "ATP:elongation factor 2 phosphotransferase activity" EXACT [EC:2.7.11.20]
synonym: "Ca/CaM-kinase III activity" EXACT [EC:2.7.11.20]
synonym: "calmodulin-dependent protein kinase III activity" EXACT [EC:2.7.11.20]
synonym: "CaM kinase III activity" EXACT [EC:2.7.11.20]
synonym: "eEF-2 kinase activity" EXACT []
synonym: "eEF2 kinase activity" EXACT [EC:2.7.11.20]
synonym: "eEF2K" RELATED [EC:2.7.11.20]
synonym: "EF2K" RELATED [EC:2.7.11.20]
synonym: "elongation factor 2 kinase activity" EXACT [EC:2.7.11.20]
synonym: "eukaryotic elongation factor 2 kinase activity" EXACT [EC:2.7.11.20]
synonym: "STK19" RELATED [EC:2.7.11.20]
xref: EC:2.7.11.20
is_a: GO:0004683 ! calmodulin-dependent protein kinase activity

[Term]
id: GO:0004687
name: myosin light chain kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (myosin-light-chain) = ADP + (myosin-light-chain) phosphate." [EC:2.7.11.18]
synonym: "ATP:myosin-light-chain O-phosphotransferase" BROAD [EC:2.7.11.18]
synonym: "ATP:myosin-light-chain O-phosphotransferase activity" EXACT [EC:2.7.11.18]
synonym: "calcium/calmodulin-dependent myosin light chain kinase activity" EXACT [EC:2.7.11.18]
synonym: "MLCK" RELATED [EC:2.7.11.18]
synonym: "MLCkase activity" EXACT [EC:2.7.11.18]
synonym: "myosin kinase activity" EXACT [EC:2.7.11.18]
synonym: "myosin light chain protein kinase activity" EXACT [EC:2.7.11.18]
synonym: "myosin light-chain kinase" BROAD [EC:2.7.11.18]
synonym: "myosin light-chain kinase (phosphorylating)" EXACT [EC:2.7.11.18]
synonym: "myosin light-chain kinase (phosphorylating) activity" EXACT [EC:2.7.11.18]
synonym: "myosin light-chain kinase activity" EXACT [EC:2.7.11.18]
synonym: "myosin-light-chain kinase activity" EXACT []
synonym: "smooth-muscle-myosin-light-chain kinase activity" NARROW [EC:2.7.11.18]
synonym: "STK18" RELATED [EC:2.7.11.18]
xref: EC:2.7.11.18
xref: MetaCyc:2.7.11.18-RXN
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004689
name: phosphorylase kinase activity
namespace: molecular_function
alt_id: GO:0008606
def: "Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a." [EC:2.7.11.19]
subset: gosubset_prok
synonym: "ATP:phosphorylase-b phosphotransferase activity" EXACT [EC:2.7.11.19]
synonym: "dephosphophosphorylase kinase activity" EXACT [EC:2.7.11.19]
synonym: "glycogen phosphorylase kinase activity" EXACT [EC:2.7.11.19]
synonym: "PHK" RELATED [EC:2.7.11.19]
synonym: "phosphorylase b kinase activity" EXACT [EC:2.7.11.19]
synonym: "phosphorylase B kinase activity" EXACT [EC:2.7.11.19]
synonym: "phosphorylase kinase (phosphorylating) activity" EXACT [EC:2.7.11.19]
synonym: "phosphorylase kinase, intrinsic catalyst activity" EXACT []
synonym: "STK17" RELATED [EC:2.7.11.19]
xref: EC:2.7.11.19
xref: MetaCyc:2.7.11.19-RXN
xref: Reactome:13545 "phosphorylase kinase activity"
is_a: GO:0004683 ! calmodulin-dependent protein kinase activity

[Term]
id: GO:0004690
name: cyclic nucleotide-dependent protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of a cyclic nucleotide." [GOC:mah]
xref: EC:2.7.11.-
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004691
name: cAMP-dependent protein kinase activity
namespace: molecular_function
alt_id: GO:0008602
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of cAMP." [EC:2.7.11.11]
synonym: "3',5' cAMP-dependent protein kinase activity" EXACT []
synonym: "3',5'-cAMP-dependent protein kinase activity" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT []
synonym: "AMPK" RELATED [EC:2.7.11.11]
synonym: "ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [EC:2.7.11.11]
synonym: "cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT []
synonym: "cyclic AMP-dependent protein kinase activity" EXACT []
synonym: "PKA" RELATED [EC:2.7.11.11]
synonym: "PKA C" RELATED [EC:2.7.11.11]
synonym: "protein kinase A activity" BROAD [EC:2.7.11.11]
synonym: "STK22" RELATED [EC:2.7.11.11]
xref: EC:2.7.11.11
xref: MetaCyc:2.7.11.11-RXN
xref: Reactome:13562 "cAMP-dependent protein kinase activity"
is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity

[Term]
id: GO:0004692
name: cGMP-dependent protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of cGMP." [GOC:mah]
synonym: "3':5'-cyclic GMP-dependent protein kinase activity" EXACT [EC:2.7.11.12]
synonym: "ATP:protein phosphotransferase (cGMP-dependent) activity" EXACT [EC:2.7.11.12]
synonym: "cGMP-dependent protein kinase ibeta activity" EXACT [EC:2.7.11.12]
synonym: "guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity" EXACT [EC:2.7.11.12]
synonym: "PKG" RELATED [EC:2.7.11.12]
synonym: "PKG 1alpha" RELATED [EC:2.7.11.12]
synonym: "PKG 1beta" RELATED [EC:2.7.11.12]
synonym: "PKG II" RELATED [EC:2.7.11.12]
synonym: "STK23" RELATED [EC:2.7.11.12]
xref: EC:2.7.11.12
xref: MetaCyc:2.7.11.12-RXN
is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity

[Term]
id: GO:0004693
name: cyclin-dependent protein kinase activity
namespace: molecular_function
alt_id: GO:0016537
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:rn, PMID:7877684, PMID:9841670]
synonym: "ATP:cyclin phosphotransferase activity" EXACT [EC:2.7.11.22]
synonym: "cdc2 kinase activity" NARROW [EC:2.7.11.22]
synonym: "CDK" RELATED [EC:2.7.11.22]
synonym: "CDK activity" EXACT []
synonym: "CDK, catalytic subunit activity" EXACT []
synonym: "cdk-activating kinase activity" EXACT [EC:2.7.11.22]
synonym: "Cdk-activating protein kinase activity" EXACT [EC:2.7.11.22]
synonym: "cyclin D-cdk6 kinase activity" NARROW [EC:2.7.11.22]
synonym: "cyclin D-dependent kinase activity" NARROW [EC:2.7.11.22]
synonym: "cyclin E kinase activity" NARROW [EC:2.7.11.22]
synonym: "cyclin-A associated kinase activity" NARROW [EC:2.7.11.22]
synonym: "cyclin-dependent kinase 6 activity" NARROW [EC:2.7.11.22]
synonym: "cyclin-dependent kinase activity" BROAD [EC:2.7.11.22]
synonym: "cyclin-dependent kinase-2 activity" NARROW [EC:2.7.11.22]
synonym: "cyclin-dependent kinase-4 activity" NARROW [EC:2.7.11.22]
synonym: "cyclin-dependent protein kinase, intrinsic catalyst activity" EXACT []
synonym: "D-type cyclin kinase activity" NARROW [EC:2.7.11.22]
synonym: "neuronal cdc2-like kinase activity" NARROW [EC:2.7.11.22]
xref: EC:2.7.11.22
xref: MetaCyc:2.7.11.22-RXN
xref: Reactome:13565 "cyclin-dependent protein kinase activity"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004694
name: eukaryotic translation initiation factor 2alpha kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (EIF2)." [GOC:mah, InterPro:IPR015516]
xref: EC:2.7.11.-
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004695
name: galactosyltransferase-associated kinase activity
namespace: molecular_function
xref: EC:2.7.11.-
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004696
name: glycogen synthase kinase 3 activity
namespace: molecular_function
xref: EC:2.7.11.-
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004697
name: protein kinase C activity
namespace: molecular_function
alt_id: GO:0004701
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, with a requirement for diacylglycerol." [EC:2.7.11.13]
synonym: "ATP:protein phosphotransferase (diacylglycerol-dependent) activity" EXACT [EC:2.7.11.13]
synonym: "cPKC" RELATED [EC:2.7.11.13]
synonym: "cPKCalpha" RELATED [EC:2.7.11.13]
synonym: "cPKCbeta" RELATED [EC:2.7.11.13]
synonym: "cPKCgamma" RELATED [EC:2.7.11.13]
synonym: "diacylglycerol-activated phospholipid-dependent PKC activity" EXACT []
synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C activity" EXACT []
synonym: "nPKC" RELATED [EC:2.7.11.13]
synonym: "nPKCdelta" RELATED [EC:2.7.11.13]
synonym: "nPKCepsilon" RELATED [EC:2.7.11.13]
synonym: "nPKCeta" RELATED [EC:2.7.11.13]
synonym: "nPKCtheta" RELATED [EC:2.7.11.13]
synonym: "PKC" RELATED [EC:2.7.11.13]
synonym: "PKC activity" EXACT []
synonym: "Pkc1p" RELATED [EC:2.7.11.13]
synonym: "PKCalpha" RELATED [EC:2.7.11.13]
synonym: "PKCbeta" RELATED [EC:2.7.11.13]
synonym: "PKCdelta" RELATED [EC:2.7.11.13]
synonym: "PKCepsilon" RELATED [EC:2.7.11.13]
synonym: "PKCgamma" RELATED [EC:2.7.11.13]
synonym: "PKCzeta" RELATED [EC:2.7.11.13]
synonym: "protein kinase Cepsilon activity" NARROW [EC:2.7.11.13]
synonym: "STK24" RELATED [EC:2.7.11.13]
xref: EC:2.7.11.13
xref: MetaCyc:2.7.11.13-RXN
xref: Reactome:13569 "protein kinase C activity"
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004698
name: calcium-dependent protein kinase C activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, with a requirement for diacylglycerol and calcium." [EC:2.7.11.13, GOC:mah]
synonym: "calcium-dependent PKC activity" EXACT []
synonym: "conventional protein kinase C activity" EXACT [PMID:9601053]
xref: EC:2.7.11.-
xref: Reactome:13572 "calcium-dependent protein kinase C activity"
is_a: GO:0004697 ! protein kinase C activity
is_a: GO:0009931 ! calcium-dependent protein serine/threonine kinase activity

[Term]
id: GO:0004699
name: calcium-independent protein kinase C activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, with a requirement for diacylglycerol but not calcium." [EC:2.7.11.13, GOC:mah]
synonym: "calcium-independent PKC activity" EXACT []
synonym: "novel protein kinase C activity" EXACT [PMID:9601053]
is_a: GO:0004697 ! protein kinase C activity

[Term]
id: GO:0004702
name: receptor signaling protein serine/threonine kinase activity
namespace: molecular_function
synonym: "receptor signalling protein serine/threonine kinase activity" EXACT []
xref: EC:2.7.11.-
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0005057 ! receptor signaling protein activity

[Term]
id: GO:0004703
name: G-protein coupled receptor kinase activity
namespace: molecular_function
alt_id: GO:0004678
def: "Catalysis of the phosphorylation of a G-protein coupled receptor, thereby modulating its activity." [GOC:dph]
synonym: "ATP:G-protein-coupled receptor phosphotransferase activity" EXACT [EC:2.7.11.16]
synonym: "G protein coupled receptor phosphorylating protein kinase activity" EXACT []
synonym: "G protein-coupled receptor kinase activity" EXACT [EC:2.7.11.16]
synonym: "G-protein-coupled receptor kinase activity" EXACT [EC:2.7.11.16]
synonym: "G-protein-coupled receptor phosphorylating protein kinase activity" EXACT []
synonym: "GPCR kinase activity" EXACT [EC:2.7.11.16]
synonym: "GPCR phosphorylating protein kinase activity" EXACT []
synonym: "GPCRK" RELATED [EC:2.7.11.16]
synonym: "GRK4" RELATED [EC:2.7.11.16]
synonym: "GRK5" RELATED [EC:2.7.11.16]
synonym: "GRK6" RELATED [EC:2.7.11.16]
synonym: "STK16" RELATED [EC:2.7.11.16]
xref: EC:2.7.11.16
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004704
name: NF-kappaB-inducing kinase activity
namespace: molecular_function
synonym: "NIK" EXACT []
xref: EC:2.7.11.-
is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity

[Term]
id: GO:0004705
name: JUN kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "c-Jun N-terminal kinase activity" NARROW []
synonym: "JNK" EXACT []
synonym: "JNK3alpha1" RELATED []
synonym: "SAPK1" NARROW []
xref: EC:2.7.11.-
xref: MetaCyc:2.7.11.24-RXN
xref: Reactome:14136 "JUN kinase activity"
is_a: GO:0016909 ! SAP kinase activity

[Term]
id: GO:0004706
name: JUN kinase kinase kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation and activation of JUN kinase kinases (JNKKs)." [GOC:bf]
synonym: "JNK kinase kinase activity" RELATED []
synonym: "JNKKK" EXACT []
xref: EC:2.7.11.-
is_a: GO:0004709 ! MAP kinase kinase kinase activity

[Term]
id: GO:0004707
name: MAP kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]
synonym: "ATP:protein phosphotransferase (MAPKK-activated) activity" EXACT [EC:2.7.11.24]
synonym: "Dp38" RELATED [EC:2.7.11.24]
synonym: "ERK" RELATED [EC:2.7.11.24]
synonym: "extracellular signal-regulated kinase activity" NARROW [EC:2.7.11.24]
synonym: "LeMPK3" RELATED [EC:2.7.11.24]
synonym: "MAP-2 kinase activity" NARROW [EC:2.7.11.24]
synonym: "MAPK" RELATED [EC:2.7.11.24]
synonym: "MBP kinase I activity" NARROW [EC:2.7.11.24]
synonym: "MBP kinase II activity" NARROW [EC:2.7.11.24]
synonym: "mitogen activated kinase activity" EXACT []
synonym: "mitogen-activated protein kinase activity" EXACT [EC:2.7.11.24]
synonym: "myelin basic protein kinase activity" NARROW [EC:2.7.11.24]
synonym: "p38-2" RELATED [EC:2.7.11.24]
synonym: "p38delta" RELATED [EC:2.7.11.24]
synonym: "p42 mitogen-activated protein kinase activity" NARROW [EC:2.7.11.24]
synonym: "p42mapk" RELATED [EC:2.7.11.24]
synonym: "p44mpk" RELATED [EC:2.7.11.24]
synonym: "PMK-1" RELATED [EC:2.7.11.24]
synonym: "PMK-2" RELATED [EC:2.7.11.24]
synonym: "PMK-3" RELATED [EC:2.7.11.24]
synonym: "pp42" RELATED [EC:2.7.11.24]
synonym: "pp44mapk" RELATED [EC:2.7.11.24]
synonym: "STK26" RELATED [EC:2.7.11.24]
xref: EC:2.7.11.24
xref: MetaCyc:2.7.11.24-RXN
xref: Reactome:4049 "MAP kinase activity"
is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity

[Term]
id: GO:0004708
name: MAP kinase kinase activity
namespace: molecular_function
def: "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase." [ISBN:0198547684]
synonym: "ATP:protein phosphotransferase (MAPKKK-activated) activity" EXACT [EC:2.7.12.2]
synonym: "ERK activator kinase activity" EXACT []
synonym: "MAP kinase kinase 4 activity" NARROW [EC:2.7.12.2]
synonym: "MAP kinase kinase 7 activity" NARROW [EC:2.7.12.2]
synonym: "MAP kinase or ERK kinase activity" RELATED [EC:2.7.12.2]
synonym: "MAP2K" RELATED [EC:2.7.12.2]
synonym: "MAPKK" RELATED [EC:2.7.12.2]
synonym: "MAPKK activity" EXACT []
synonym: "MAPKK1" RELATED [EC:2.7.12.2]
synonym: "MEK activity" BROAD []
synonym: "MEK1" RELATED [EC:2.7.12.2]
synonym: "MEK2" RELATED [EC:2.7.12.2]
synonym: "mitogen-activated protein kinase kinase activity" EXACT [EC:2.7.12.2]
synonym: "MKK" RELATED [EC:2.7.12.2]
synonym: "MKK2" RELATED [EC:2.7.12.2]
synonym: "MKK4" RELATED [EC:2.7.12.2]
synonym: "MKK6" RELATED [EC:2.7.12.2]
synonym: "MKK7" RELATED [EC:2.7.12.2]
synonym: "STK27" RELATED [EC:2.7.12.2]
xref: EC:2.7.11.-
xref: MetaCyc:2.7.12.2-RXN
is_a: GO:0004712 ! protein serine/threonine/tyrosine kinase activity

[Term]
id: GO:0004709
name: MAP kinase kinase kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]
synonym: "ATP:protein phosphotransferase (MAPKKKK-activated) activity" EXACT [EC:2.7.11.25]
synonym: "cMos" RELATED [EC:2.7.11.25]
synonym: "cRaf" RELATED [EC:2.7.11.25]
synonym: "MAP3K" RELATED [EC:2.7.11.25]
synonym: "MAPKKK activity" EXACT [EC:2.7.11.25]
synonym: "MEK kinase activity" EXACT [EC:2.7.11.25]
synonym: "MEKK" RELATED [EC:2.7.11.25]
synonym: "MEKK1" RELATED [EC:2.7.11.25]
synonym: "MEKK2" RELATED [EC:2.7.11.25]
synonym: "MEKK3" RELATED [EC:2.7.11.25]
synonym: "Mil/Raf" RELATED [EC:2.7.11.25]
synonym: "mitogen-activated protein kinase kinase kinase activity" EXACT [EC:2.7.11.25]
synonym: "MLK-like mitogen-activated protein triple kinase activity" NARROW [EC:2.7.11.25]
synonym: "MLTK" RELATED [EC:2.7.11.25]
synonym: "MLTKa" RELATED [EC:2.7.11.25]
synonym: "MLTKb" RELATED [EC:2.7.11.25]
synonym: "REKS" RELATED [EC:2.7.11.25]
synonym: "STK28" RELATED [EC:2.7.11.25]
xref: EC:2.7.11.25
xref: MetaCyc:2.7.11.25-RXN
is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity

[Term]
id: GO:0004710
name: MAP/ERK kinase kinase activity
namespace: molecular_function
synonym: "MEKK activity" EXACT []
xref: EC:2.7.11.-
xref: MetaCyc:2.7.11.25-RXN
is_a: GO:0004709 ! MAP kinase kinase kinase activity

[Term]
id: GO:0004711
name: ribosomal protein S6 kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of ribosomal protein S6." [GOC:mah, PMID:9822608]
xref: EC:2.7.11.-
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0004712
name: protein serine/threonine/tyrosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein serine/threonine/tyrosine = ADP + protein serine/threonine/tyrosine phosphate." [GOC:mah]
subset: gosubset_prok
synonym: "ADK1" RELATED [EC:2.7.12.1]
synonym: "Arabidopsis dual specificity kinase 1 activity" NARROW [EC:2.7.12.1]
synonym: "ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating) activity" EXACT [EC:2.7.12.1]
synonym: "CLK1" RELATED [EC:2.7.12.1]
synonym: "dDYRK2" RELATED [EC:2.7.12.1]
synonym: "dual-specificity kinase activity" BROAD [EC:2.7.12.1]
synonym: "dual-specificity protein kinase" BROAD []
synonym: "Mps1p" RELATED [EC:2.7.12.1]
synonym: "protein threonine/tyrosine kinase activity" NARROW []
xref: EC:2.7.112.1
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0004713
name: protein tyrosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]
subset: gosubset_prok
synonym: "protein-tyrosine kinase activity" EXACT []
xref: EC:2.7.10
xref: MetaCyc:2.7.10.1-RXN
xref: MetaCyc:2.7.10.2-RXN
xref: Reactome:11065 "protein tyrosine kinase activity"
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0004714
name: transmembrane receptor protein tyrosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate, to initiate a change in cell activity." [EC:2.7.10.1, GOC:mah]
subset: gosubset_prok
synonym: "anaplastic lymphoma kinase activity" NARROW [EC:2.7.10.1]
synonym: "ATP:protein-L-tyrosine O-phosphotransferase (receptor-type) activity" EXACT [EC:2.7.10.1]
synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.1]
synonym: "Drosophila Eph kinase activity" NARROW [EC:2.7.10.1]
synonym: "ephrin-B3 receptor tyrosine kinase activity" NARROW [EC:2.7.10.1]
synonym: "insulin receptor protein-tyrosine kinase activity" NARROW [EC:2.7.10.1]
synonym: "neurite outgrowth regulating kinase activity" NARROW [EC:2.7.10.1]
synonym: "neurotrophin TRK receptor activity" RELATED []
synonym: "neurotrophin TRKA receptor activity" RELATED []
synonym: "neurotrophin TRKB receptor activity" RELATED []
synonym: "neurotrophin TRKC receptor activity" RELATED []
synonym: "novel oncogene with kinase-domain activity" NARROW [EC:2.7.10.1]
synonym: "receptor protein tyrosine kinase activity" EXACT [EC:2.7.10.1]
synonym: "receptor protein-tyrosine kinase activity" EXACT [EC:2.7.10.1]
synonym: "sevenless receptor activity" RELATED []
xref: EC:2.7.10.1
xref: MetaCyc:2.7.10.1-RXN
xref: Reactome:11064 "transmembrane receptor protein tyrosine kinase activity"
is_a: GO:0004713 ! protein tyrosine kinase activity
is_a: GO:0019199 ! transmembrane receptor protein kinase activity

[Term]
id: GO:0004715
name: non-membrane spanning protein tyrosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.2]
synonym: "ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [EC:2.7.10.2]
synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.2]
synonym: "Bruton's tyrosine kinase activity" NARROW [EC:2.7.10.2]
synonym: "cytoplasmic protein tyrosine kinase activity" NARROW [EC:2.7.10.2]
synonym: "focal adhesion kinase activity" NARROW [EC:2.7.10.2]
synonym: "janus kinase 1 activity" NARROW [EC:2.7.10.2]
synonym: "janus kinase 2 activity" NARROW [EC:2.7.10.2]
synonym: "janus kinase 3 activity" NARROW [EC:2.7.10.2]
synonym: "non-specific protein-tyrosine kinase activity" EXACT [EC:2.7.10.2]
synonym: "p60c-src protein tyrosine kinase activity" NARROW [EC:2.7.10.2]
xref: EC:2.7.10.2
xref: MetaCyc:2.7.10.1-RXN
xref: MetaCyc:2.7.10.2-RXN
is_a: GO:0004713 ! protein tyrosine kinase activity

[Term]
id: GO:0004716
name: receptor signaling protein tyrosine kinase activity
namespace: molecular_function
synonym: "receptor signalling protein tyrosine kinase activity" EXACT []
xref: EC:2.7.10.-
is_a: GO:0004713 ! protein tyrosine kinase activity
is_a: GO:0005057 ! receptor signaling protein activity

[Term]
id: GO:0004717
name: focal adhesion kinase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jic]
comment: This term was made obsolete because it represents a gene product, and because the gene was named after its location of action rather than after its molecular function.
synonym: "FAK" EXACT []
is_obsolete: true
replaced_by: GO:0004713

[Term]
id: GO:0004718
name: Janus kinase activity
namespace: molecular_function
synonym: "JAK" EXACT []
xref: EC:2.7.11.-
is_a: GO:0004716 ! receptor signaling protein tyrosine kinase activity

[Term]
id: GO:0004719
name: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77]
subset: gosubset_prok
synonym: "D-aspartyl/L-isoaspartyl methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "L-aspartyl/L-isoaspartyl protein methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "L-isoaspartyl protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "protein (D-aspartate) methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "protein beta-aspartate O-methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "protein D-aspartate methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "protein L-isoaspartate methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "protein L-isoaspartyl methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "protein O-methyltransferase (L-isoaspartate)" EXACT [EC:2.1.1.77]
synonym: "protein-beta-aspartate O-methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "protein-L-isoaspartate O-methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "protein-L-isoaspartate(D-aspartate) O-methyltransferase activity" EXACT [EC:2.1.1.77]
synonym: "S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity" EXACT [EC:2.1.1.77]
xref: EC:2.1.1.77
xref: MetaCyc:2.1.1.77-RXN
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004720
name: protein-lysine 6-oxidase activity
namespace: molecular_function
alt_id: GO:0018056
def: "Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + H2O2." [EC:1.4.3.13]
synonym: "lysyl oxidase activity" EXACT [EC:1.4.3.13]
synonym: "protein-L-lysine:oxygen 6-oxidoreductase (deaminating)" EXACT [EC:1.4.3.13]
xref: EC:1.4.3.13
xref: MetaCyc:PROTEIN-LYSINE-6-OXIDASE-RXN
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0004721
name: phosphoprotein phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]
subset: goslim_candida
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
synonym: "phosphoprotein phosphohydrolase activity" EXACT [EC:3.1.3.16]
synonym: "protein phosphatase activity" EXACT []
synonym: "protein phosphatase-1 activity" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2A activity" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2B activity" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase-2C activity" NARROW [EC:3.1.3.16]
xref: EC:3.1.3.16
xref: MetaCyc:3.1.3.16-RXN
xref: Reactome:1887 "phosphoprotein phosphatase activity"
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0004722
name: protein serine/threonine phosphatase activity
namespace: molecular_function
alt_id: GO:0000158
alt_id: GO:0000163
alt_id: GO:0008598
alt_id: GO:0008600
alt_id: GO:0015071
alt_id: GO:0030357
alt_id: GO:0030358
alt_id: GO:0030360
alt_id: GO:0030361
def: "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [GOC:bf]
subset: gosubset_prok
synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase" NARROW [EC:3.1.3.16]
synonym: "Aspergillus awamori acid protein phosphatase" NARROW [EC:3.1.3.16]
synonym: "BCKDH phosphatase" NARROW [EC:3.1.3.16]
synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" NARROW [EC:3.1.3.16]
synonym: "calcineurin" NARROW []
synonym: "casein phosphatase" NARROW [EC:3.1.3.16]
synonym: "HMG-CoA reductase phosphatase" NARROW [EC:3.1.3.16]
synonym: "phosphatase 2A" NARROW [EC:3.1.3.16]
synonym: "phosphatase 2B" NARROW [EC:3.1.3.16]
synonym: "phosphatase C-II" NARROW [EC:3.1.3.16]
synonym: "phosphatase H-II" NARROW [EC:3.1.3.16]
synonym: "phosphatase I" NARROW [EC:3.1.3.16]
synonym: "phosphatase IB" NARROW [EC:3.1.3.16]
synonym: "phosphatase II" NARROW [EC:3.1.3.16]
synonym: "phosphatase III" NARROW [EC:3.1.3.16]
synonym: "phosphatase IV" NARROW [EC:3.1.3.16]
synonym: "phosphatase SP" NARROW [EC:3.1.3.16]
synonym: "phosphopyruvate dehydrogenase phosphatase" NARROW [EC:3.1.3.16]
synonym: "phosphospectrin phosphatase" NARROW [EC:3.1.3.16]
synonym: "polycation modulated (PCM-) phosphatase" NARROW [EC:3.1.3.16]
synonym: "protein D phosphatase" NARROW [EC:3.1.3.16]
synonym: "protein phosphatase type 1 activity" NARROW []
synonym: "protein phosphatase type 1, intrinsic catalyst activity" NARROW []
synonym: "protein phosphatase type 2A activity" NARROW []
synonym: "protein phosphatase type 2A, intrinsic catalyst activity" NARROW []
synonym: "protein phosphatase type 2B activity" NARROW []
synonym: "protein phosphatase type 2B, intrinsic catalyst activity" NARROW []
synonym: "protein phosphatase type 2C activity" NARROW []
synonym: "protein phosphatase type 4 activity" NARROW []
synonym: "protein phosphatase type 4, intrinsic catalyst activity" NARROW []
synonym: "protein phosphatase X" NARROW []
synonym: "serine/threonine specific protein phosphatase activity" EXACT []
xref: MetaCyc:3.1.3.16-RXN
xref: Reactome:14173 "protein serine/threonine phosphatase activity"
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0004723
name: calcium-dependent protein serine/threonine phosphatase activity
namespace: molecular_function
alt_id: GO:0008596
def: "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium ions." [EC:3.1.3.16, GOC:mah]
synonym: "calcineurin" NARROW []
synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity" EXACT []
is_a: GO:0004722 ! protein serine/threonine phosphatase activity

[Term]
id: GO:0004724
name: magnesium-dependent protein serine/threonine phosphatase activity
namespace: molecular_function
def: "Catalysis of the removal of a serine- or threonine-bound phosphate group from a protein; action dependent on magnesium." [EC:3.1.3.16]
is_a: GO:0004722 ! protein serine/threonine phosphatase activity

[Term]
id: GO:0004725
name: protein tyrosine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]
subset: gosubset_prok
synonym: "[phosphotyrosine]protein phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [EC:3.1.3.48]
synonym: "phosphotyrosine histone phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "phosphotyrosine phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "phosphotyrosine protein phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "phosphotyrosylprotein phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "PPT-phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "protein phosphotyrosine phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "protein-tyrosine-phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "protein-tyrosine-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.48]
synonym: "PTP-phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "PTPase activity" EXACT [EC:3.1.3.48]
synonym: "tyrosine O-phosphate phosphatase activity" EXACT [EC:3.1.3.48]
synonym: "tyrosylprotein phosphatase activity" EXACT [EC:3.1.3.48]
xref: EC:3.1.3.48
xref: MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN
xref: Reactome:11061 "protein tyrosine phosphatase activity"
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0004726
name: non-membrane spanning protein tyrosine phosphatase activity
namespace: molecular_function
subset: gosubset_prok
xref: Reactome:14178 "non-membrane spanning protein tyrosine phosphatase activity"
is_a: GO:0004725 ! protein tyrosine phosphatase activity

[Term]
id: GO:0004727
name: prenylated protein tyrosine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate." [EC:3.1.3.48]
is_a: GO:0004725 ! protein tyrosine phosphatase activity

[Term]
id: GO:0004728
name: receptor signaling protein tyrosine phosphatase activity
namespace: molecular_function
synonym: "receptor signalling protein tyrosine phosphatase activity" EXACT []
is_a: GO:0004725 ! protein tyrosine phosphatase activity
is_a: GO:0005057 ! receptor signaling protein activity

[Term]
id: GO:0004729
name: oxygen-dependent protoporphyrinogen oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: protoporphyrinogen-IX + O2 = protoporphyrin-IX + H2O2." [EC:1.3.3.4]
subset: gosubset_prok
synonym: "protoporphyrinogen-IX:oxygen oxidoreductase activity" EXACT [EC:1.3.3.4]
xref: EC:1.3.3.4
xref: MetaCyc:PROTOPORGENOXI-RXN
xref: Reactome:14184 "protoporphyrinogen oxidase activity"
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
is_a: GO:0070818 ! protoporphyrinogen oxidase activity

[Term]
id: GO:0004730
name: pseudouridylate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O." [EC:4.2.1.70]
comment: Note that this term should not be confused with 'pseudouridine synthase activity ; GO:0009982', which refers to the intramolecular isomerization of uridine to pseudouridine.
subset: gosubset_prok
synonym: "5-ribosyluracil 5-phosphate synthetase activity" EXACT [EC:4.2.1.70]
synonym: "pseudouridine monophosphate synthase activity" EXACT []
synonym: "pseudouridine monophosphate synthetase activity" EXACT [EC:4.2.1.70]
synonym: "pseudouridylate synthetase activity" EXACT [EC:4.2.1.70]
synonym: "pseudouridylic acid synthetase activity" EXACT [EC:4.2.1.70]
synonym: "psiUMP synthetase activity" EXACT [EC:4.2.1.70]
synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate)" EXACT [EC:4.2.1.70]
synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)" EXACT [EC:4.2.1.70]
synonym: "uracil hydrolyase activity" RELATED [EC:4.2.1.70]
xref: EC:4.2.1.70
xref: MetaCyc:PSEUDOURIDYLATE-SYNTHASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004731
name: purine-nucleoside phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate." [EC:2.4.2.1]
subset: gosubset_prok
synonym: "inosine phosphorylase activity" NARROW [EC:2.4.2.1]
synonym: "inosine-guanosine phosphorylase activity" EXACT [EC:2.4.2.1]
synonym: "PNPase activity" EXACT [EC:2.4.2.1]
synonym: "PUNPI" RELATED [EC:2.4.2.1]
synonym: "PUNPII" RELATED [EC:2.4.2.1]
synonym: "purine deoxynucleoside phosphorylase activity" EXACT [EC:2.4.2.1]
synonym: "purine deoxyribonucleoside phosphorylase activity" EXACT [EC:2.4.2.1]
synonym: "purine nucleoside phosphorylase activity" EXACT [EC:2.4.2.1]
synonym: "purine ribonucleoside phosphorylase activity" EXACT [EC:2.4.2.1]
synonym: "purine-nucleoside:phosphate ribosyltransferase activity" EXACT [EC:2.4.2.1]
xref: EC:2.4.2.1
xref: MetaCyc:PNP-RXN
xref: Reactome:14201 "purine-nucleoside phosphorylase activity"
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004732
name: pyridoxal oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + H2O2." [EC:1.2.3.8]
synonym: "pyridoxal:oxygen 4-oxidoreductase activity" EXACT [EC:1.2.3.8]
xref: EC:1.2.3.8
xref: MetaCyc:PYRIDOXAL-OXIDASE-RXN
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0004733
name: pyridoxamine-phosphate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2." [EC:1.4.3.5]
subset: gosubset_prok
synonym: "PdxH" RELATED [EC:1.4.3.5]
synonym: "PMP oxidase activity" EXACT [EC:1.4.3.5]
synonym: "pyridoxal 5'-phosphate synthase activity" EXACT [EC:1.4.3.5]
synonym: "pyridoxamine 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5]
synonym: "pyridoxamine phosphate oxidase activity" EXACT [EC:1.4.3.5]
synonym: "pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5]
synonym: "pyridoxaminephosphate oxidase (EC 1.4.3.5: deaminating)" EXACT [EC:1.4.3.5]
synonym: "pyridoxine (pyridoxamine) 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5]
synonym: "pyridoxine (pyridoxamine)phosphate oxidase activity" EXACT [EC:1.4.3.5]
synonym: "pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5]
xref: EC:1.4.3.5
xref: MetaCyc:PMPOXI-RXN
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0004734
name: pyrimidodiazepine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione." [EC:1.5.4.1]
synonym: "PDA synthase activity" EXACT [EC:1.5.4.1]
synonym: "pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)" EXACT [EC:1.5.4.1]
xref: EC:1.5.4.1
xref: MetaCyc:1.5.4.1-RXN
is_a: GO:0016648 ! oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor

[Term]
id: GO:0004735
name: pyrroline-5-carboxylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [EC:1.5.1.2]
subset: gosubset_prok
synonym: "1-pyrroline-5-carboxylate reductase activity" EXACT [EC:1.5.1.2]
synonym: "L-proline oxidase activity" EXACT [EC:1.5.1.2]
synonym: "L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [EC:1.5.1.2]
synonym: "L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [EC:1.5.1.2]
synonym: "NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [EC:1.5.1.2]
synonym: "P5CR activity" EXACT [EC:1.5.1.2]
xref: EC:1.5.1.2
xref: MetaCyc:PYRROLINECARBREDUCT-RXN
xref: Reactome:14208 "pyrroline-5-carboxylate reductase activity"
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004736
name: pyruvate carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate." [EC:6.4.1.1]
subset: gosubset_prok
synonym: "pyruvate:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.1]
synonym: "pyruvic carboxylase activity" EXACT [EC:6.4.1.1]
xref: EC:6.4.1.1
xref: MetaCyc:PYRUVATE-CARBOXYLASE-RXN
xref: Reactome:14209 "pyruvate carboxylase activity"
is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds

[Term]
id: GO:0004737
name: pyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2." [EC:4.1.1.1]
subset: gosubset_prok
synonym: "2-oxo-acid carboxy-lyase (aldehyde-forming)" EXACT [EC:4.1.1.1]
synonym: "2-oxo-acid carboxy-lyase activity" EXACT [EC:4.1.1.1]
synonym: "alpha-carboxylase activity" EXACT [EC:4.1.1.1]
synonym: "alpha-ketoacid carboxylase activity" EXACT [EC:4.1.1.1]
synonym: "pyruvic decarboxylase activity" EXACT [EC:4.1.1.1]
xref: EC:4.1.1.1
xref: MetaCyc:PYRUVATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004738
name: pyruvate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the oxidative decarboxylation of pyruvate." [ISBN:0716020094]
subset: gosubset_prok
synonym: "pyruvic acid dehydrogenase activity" EXACT [EC:1.2.4.1]
synonym: "pyruvic dehydrogenase activity" EXACT [EC:1.2.4.1]
xref: MetaCyc:PYRUVOXID-RXN
xref: MetaCyc:RXN0-1134
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0004739
name: pyruvate dehydrogenase (acetyl-transferring) activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [EC:1.2.4.1]
subset: gosubset_prok
synonym: "MtPDC (mitochondrial pyruvate dehydogenase complex) activity" NARROW [EC:1.2.4.1]
synonym: "PDH" RELATED [EC:1.2.4.1]
synonym: "pyruvate dehydrogenase (lipoamide) activity" EXACT []
synonym: "pyruvate dehydrogenase complex activity" RELATED [EC:1.2.4.1]
synonym: "pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)" EXACT [EC:1.2.4.1]
synonym: "pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity" EXACT [EC:1.2.4.1]
xref: EC:1.2.4.1
xref: Reactome:14213 "pyruvate dehydrogenase (acetyl-transferring) activity"
is_a: GO:0004738 ! pyruvate dehydrogenase activity
is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

[Term]
id: GO:0004740
name: pyruvate dehydrogenase (acetyl-transferring) kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.2]
synonym: "[pyruvate dehydrogenase (lipoamide)] kinase activity" EXACT []
synonym: "ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity" EXACT [EC:2.7.11.2]
synonym: "PDH kinase activity" EXACT [EC:2.7.11.2]
synonym: "PDHK" RELATED [EC:2.7.11.2]
synonym: "PDK" RELATED [EC:2.7.11.2]
synonym: "PDK1" RELATED [EC:2.7.11.2]
synonym: "PDK2" RELATED [EC:2.7.11.2]
synonym: "PDK3" RELATED [EC:2.7.11.2]
synonym: "PDK4" RELATED [EC:2.7.11.2]
synonym: "pyruvate dehydrogenase (lipoamide) kinase activity" EXACT []
synonym: "pyruvate dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.2]
synonym: "pyruvate dehydrogenase kinase activator protein activity" NARROW [EC:2.7.11.2]
synonym: "pyruvate dehydrogenase kinase activity" EXACT [EC:2.7.11.2]
synonym: "STK1" RELATED [EC:2.7.11.2]
xref: EC:2.7.11.2
xref: MetaCyc:2.7.11.2-RXN
xref: Reactome:14233 "pyruvate dehydrogenase (acetyl-transferring) kinase activity"
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0004741
name: [pyruvate dehydrogenase (lipoamide)] phosphatase activity
namespace: molecular_function
alt_id: GO:0019906
def: "Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate." [EC:3.1.3.43]
synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity" EXACT []
synonym: "phosphopyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43]
synonym: "pyruvate dehydrogenase (lipoamide) phosphatase activity" EXACT []
synonym: "pyruvate dehydrogenase (lipoamide)-phosphatase activity" EXACT [EC:3.1.3.43]
synonym: "pyruvate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.43]
synonym: "pyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43]
xref: EC:3.1.3.43
xref: MetaCyc:3.1.3.43-RXN
xref: Reactome:14236 "[pyruvate dehydrogenase (lipoamide)] phosphatase activity"
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0004742
name: dihydrolipoyllysine-residue acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide." [EC:2.3.1.12]
subset: gosubset_prok
synonym: "acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "acetyl-CoA:dihydrolipoamide S-acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "dihydrolipoamide S-acetyltransferase activity" EXACT []
synonym: "dihydrolipoate acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "dihydrolipoic transacetylase activity" EXACT [EC:2.3.1.12]
synonym: "dihydrolipoyl acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "lipoate acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "lipoate transacetylase activity" EXACT [EC:2.3.1.12]
synonym: "lipoic acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "lipoic acid acetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "lipoic transacetylase activity" EXACT [EC:2.3.1.12]
synonym: "lipoylacetyltransferase activity" EXACT [EC:2.3.1.12]
synonym: "thioltransacetylase A activity" NARROW [EC:2.3.1.12]
synonym: "transacetylase X activity" NARROW [EC:2.3.1.12]
xref: EC:2.3.1.12
xref: Reactome:14238 "dihydrolipoyllysine-residue acetyltransferase activity"
is_a: GO:0016418 ! S-acetyltransferase activity
is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity

[Term]
id: GO:0004743
name: pyruvate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40]
subset: gosubset_prok
synonym: "ATP:pyruvate 2-O-phosphotransferase activity" EXACT [EC:2.7.1.40]
synonym: "phosphoenol transphosphorylase activity" EXACT [EC:2.7.1.40]
synonym: "phosphoenolpyruvate kinase activity" EXACT [EC:2.7.1.40]
xref: EC:2.7.1.40
xref: MetaCyc:PEPDEPHOS-RXN
xref: Reactome:14240 "pyruvate kinase activity"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004744
name: retinal isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-retinal = 11-cis-retinal." [EC:5.2.1.3]
synonym: "all-trans-retinal 11-cis-trans-isomerase activity" EXACT [EC:5.2.1.3]
synonym: "retinene isomerase activity" RELATED [EC:5.2.1.3]
synonym: "retinoid isomerase activity" BROAD [EC:5.2.1.3]
xref: EC:5.2.1.3
xref: MetaCyc:RETINAL-ISOMERASE-RXN
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0004745
name: retinol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [EC:1.1.1.105]
subset: gosubset_prok
synonym: "all-trans retinol dehydrogenase activity" EXACT [EC:1.1.1.105]
synonym: "MDR" RELATED [EC:1.1.1.105]
synonym: "microsomal retinol dehydrogenase activity" EXACT [EC:1.1.1.105]
synonym: "retinene reductase activity" EXACT [EC:1.1.1.105]
synonym: "retinol (vitamin A1) dehydrogenase activity" EXACT [EC:1.1.1.105]
synonym: "retinol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.105]
xref: EC:1.1.1.105
xref: MetaCyc:RETINOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004746
name: riboflavin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine." [EC:2.5.1.9]
subset: gosubset_prok
synonym: "6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase activity" EXACT [EC:2.5.1.9]
synonym: "heavy riboflavin synthase" NARROW [EC:2.5.1.9]
synonym: "light riboflavin synthase" NARROW [EC:2.5.1.9]
synonym: "lumazine synthase activity" BROAD [BRENDA:2.5.1.9]
synonym: "riboflavin synthetase activity" EXACT [EC:2.5.1.9]
synonym: "riboflavine synthase activity" EXACT [EC:2.5.1.9]
synonym: "riboflavine synthetase activity" EXACT [EC:2.5.1.9]
synonym: "vitamin B2 synthase activity" EXACT []
xref: EC:2.5.1.9
xref: MetaCyc:RIBOFLAVIN-SYN-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004747
name: ribokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate." [EC:2.7.1.15]
subset: gosubset_prok
synonym: "ATP:D-ribose 5-phosphotransferase activity" EXACT [EC:2.7.1.15]
synonym: "D-ribokinase activity" EXACT [EC:2.7.1.15]
synonym: "deoxyribokinase activity" EXACT [EC:2.7.1.15]
synonym: "ribokinase (phosphorylating)" EXACT [EC:2.7.1.15]
xref: EC:2.7.1.15
xref: MetaCyc:RIBOKIN-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0004748
name: ribonucleoside-diphosphate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1]
subset: gosubset_prok
synonym: "2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.1]
synonym: "2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.1]
synonym: "nucleoside diphosphate reductase activity" EXACT [EC:1.17.4.1]
synonym: "purine/pyrimidine nucleoside diphosphate reduction" RELATED []
synonym: "ribonucleoside 5'-diphosphate reductase activity" EXACT [EC:1.17.4.1]
synonym: "ribonucleoside diphosphate reductase activity" EXACT [EC:1.17.4.1]
synonym: "ribonucleotide diphosphate reductase activity" EXACT [EC:1.17.4.1]
synonym: "ribonucleotide reductase activity" BROAD [EC:1.17.4.1]
synonym: "RNR" EXACT []
xref: EC:1.17.4.1
xref: MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN
is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor

[Term]
id: GO:0004749
name: ribose phosphate diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.7.6.1]
subset: gosubset_prok
synonym: "5-phosphoribose pyrophosphorylase activity" EXACT [EC:2.7.6.1]
synonym: "5-phosphoribosyl-1-pyrophosphate synthetase activity" EXACT [EC:2.7.6.1]
synonym: "5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity" EXACT [EC:2.7.6.1]
synonym: "ATP:D-ribose-5-phosphate diphosphotransferase activity" EXACT [EC:2.7.6.1]
synonym: "phosphoribosyl diphosphate synthetase activity" EXACT [EC:2.7.6.1]
synonym: "phosphoribosyl pyrophosphate synthetase activity" EXACT [EC:2.7.6.1]
synonym: "phosphoribosyl-diphosphate synthetase activity" EXACT [EC:2.7.6.1]
synonym: "phosphoribosylpyrophosphate synthase activity" EXACT [EC:2.7.6.1]
synonym: "phosphoribosylpyrophosphate synthetase activity" EXACT [EC:2.7.6.1]
synonym: "PP-ribose P synthetase activity" EXACT [EC:2.7.6.1]
synonym: "PPRibP synthetase activity" EXACT [EC:2.7.6.1]
synonym: "PRPP synthetase activity" EXACT [EC:2.7.6.1]
synonym: "pyrophosphoribosylphosphate synthetase activity" EXACT [EC:2.7.6.1]
synonym: "ribophosphate pyrophosphokinase activity" EXACT [EC:2.7.6.1]
synonym: "ribose-5-phosphate pyrophosphokinase activity" EXACT [EC:2.7.6.1]
synonym: "ribose-phosphate diphosphokinase activity" EXACT [EC:2.7.6.1]
synonym: "ribose-phosphate pyrophosphokinase activity" EXACT []
xref: EC:2.7.6.1
xref: MetaCyc:PRPPSYN-RXN
xref: MetaCyc:PWY0-662
xref: Reactome:14245 "ribose phosphate diphosphokinase activity"
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0004750
name: ribulose-phosphate 3-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.1]
subset: gosubset_prok
synonym: "D-ribulose 5-phosphate epimerase activity" EXACT [EC:5.1.3.1]
synonym: "D-ribulose phosphate-3-epimerase activity" EXACT [EC:5.1.3.1]
synonym: "D-ribulose-5-P 3-epimerase activity" EXACT [EC:5.1.3.1]
synonym: "D-ribulose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1]
synonym: "D-ribulose-5-phosphate epimerase activity" EXACT [EC:5.1.3.1]
synonym: "D-xylulose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1]
synonym: "erythrose-4-phosphate epimerase activity" EXACT [EC:5.1.3.1]
synonym: "erythrose-4-phosphate isomerase activity" EXACT [EC:5.1.3.1]
synonym: "pentose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1]
synonym: "phosphoketopentose 3-epimerase activity" EXACT [EC:5.1.3.1]
synonym: "phosphoketopentose epimerase activity" EXACT [EC:5.1.3.1]
synonym: "phosphoribulose epimerase activity" EXACT [EC:5.1.3.1]
synonym: "ribulose 5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1]
synonym: "xylulose phosphate 3-epimerase activity" EXACT [EC:5.1.3.1]
xref: EC:5.1.3.1
xref: MetaCyc:RIBULP3EPIM-RXN
xref: Reactome:14262 "ribulose-phosphate 3-epimerase activity"
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0004751
name: ribose-5-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate." [EC:5.3.1.6]
subset: gosubset_prok
synonym: "5-phosphoribose isomerase activity" EXACT [EC:5.3.1.6]
synonym: "D-ribose 5-phosphate isomerase activity" EXACT [EC:5.3.1.6]
synonym: "D-ribose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.6]
synonym: "D-ribose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.6]
synonym: "phosphopentoseisomerase activity" EXACT [EC:5.3.1.6]
synonym: "phosphopentosisomerase activity" EXACT [EC:5.3.1.6]
synonym: "phosphoriboisomerase activity" EXACT [EC:5.3.1.6]
synonym: "ribose 5-phosphate epimerase activity" EXACT [EC:5.3.1.6]
synonym: "ribose phosphate isomerase activity" EXACT [EC:5.3.1.6]
xref: EC:5.3.1.6
xref: MetaCyc:RIB5PISOM-RXN
xref: Reactome:14263 "ribose-5-phosphate isomerase activity"
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004753
name: saccharopine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor." [GOC:mah]
subset: gosubset_prok
synonym: "lysine-2-oxoglutarate reductase activity" EXACT [EC:1.5.1.-]
synonym: "lysine-ketoglutarate reductase activity" EXACT [EC:1.5.1.-]
xref: EC:1.5.1.-
xref: MetaCyc:1.5.1.7-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004754
name: saccharopine dehydrogenase (NAD+, L-lysine-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+." [EC:1.5.1.7]
subset: gosubset_prok
synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7]
synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)" EXACT [EC:1.5.1.7]
synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)" EXACT [EC:1.5.1.7]
synonym: "N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7]
synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7]
xref: EC:1.5.1.7
xref: MetaCyc:1.5.1.7-RXN
xref: Reactome:70922 "saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"
is_a: GO:0004753 ! saccharopine dehydrogenase activity

[Term]
id: GO:0004755
name: saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADPH + H+." [EC:1.5.1.10]
subset: gosubset_prok
synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.10]
synonym: "aminoadipate semialdehyde-glutamate reductase activity" EXACT [EC:1.5.1.10]
synonym: "aminoadipic semialdehyde-glutamate reductase activity" EXACT [EC:1.5.1.10]
synonym: "aminoadipic semialdehyde-glutamic reductase activity" EXACT [EC:1.5.1.10]
synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)" EXACT [EC:1.5.1.10]
synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.10]
synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase activity" EXACT [EC:1.5.1.10]
synonym: "saccharopine reductase activity" EXACT [EC:1.5.1.10]
xref: EC:1.5.1.10
xref: MetaCyc:RXN3O-127
xref: Reactome:70935 "saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"
is_a: GO:0004753 ! saccharopine dehydrogenase activity

[Term]
id: GO:0004756
name: selenide, water dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + selenide + H2O = AMP + selenophosphate + phosphate." [EC:2.7.9.3]
subset: gosubset_prok
synonym: "ATP:selenide, water phosphotransferase activity" EXACT [EC:2.7.9.3]
synonym: "selenide,water dikinase activity" EXACT [EC:2.7.9.3]
synonym: "selenium donor protein activity" EXACT [EC:2.7.9.3]
synonym: "selenophosphate synthase activity" EXACT []
synonym: "selenophosphate synthetase activity" EXACT [EC:2.7.9.3]
xref: EC:2.7.9.3
xref: MetaCyc:2.7.9.3-RXN
xref: UM-BBD_enzymeID:e0509
is_a: GO:0016301 ! kinase activity
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0004757
name: sepiapterin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+." [EC:1.1.1.153]
subset: gosubset_prok
synonym: "7,8-dihydrobiopterin:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.153]
xref: EC:1.1.1.153
xref: MetaCyc:SEPIAPTERIN-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004758
name: serine C-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2." [EC:2.3.1.50]
synonym: "3-oxosphinganine synthetase activity" EXACT [EC:2.3.1.50]
synonym: "acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [EC:2.3.1.50]
synonym: "palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [EC:2.3.1.50]
synonym: "serine palmitoyltransferase" BROAD []
synonym: "SPT" RELATED [EC:2.3.1.50]
xref: EC:2.3.1.50
xref: MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN
is_a: GO:0016454 ! C-palmitoyltransferase activity

[Term]
id: GO:0004760
name: serine-pyruvate transaminase activity
namespace: molecular_function
alt_id: GO:0004761
alt_id: GO:0004762
alt_id: GO:0004763
def: "Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine." [EC:2.6.1.51]
subset: gosubset_prok
synonym: "hydroxypyruvate:L-alanine transaminase activity" EXACT [EC:2.6.1.51]
synonym: "L-serine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.51]
synonym: "serine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.51]
synonym: "serine-pyruvate aminotransferase activity" EXACT []
synonym: "serine-pyruvate aminotransferase, type 1" NARROW []
synonym: "serine-pyruvate aminotransferase, type 2A" NARROW []
synonym: "serine-pyruvate aminotransferase, type 2B" NARROW []
synonym: "SPT" RELATED [EC:2.6.1.51]
xref: EC:2.6.1.51
xref: MetaCyc:SERINE--PYRUVATE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0004764
name: shikimate 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+." [EC:1.1.1.25]
subset: gosubset_prok
synonym: "5-dehydroshikimate reductase activity" EXACT [EC:1.1.1.25]
synonym: "5-dehydroshikimic reductase activity" EXACT [EC:1.1.1.25]
synonym: "dehydroshikimic reductase activity" EXACT [EC:1.1.1.25]
synonym: "DHS reductase activity" EXACT [EC:1.1.1.25]
synonym: "shikimate oxidoreductase activity" EXACT [EC:1.1.1.25]
synonym: "shikimate:NADP(+) 5-oxidoreductase activity" EXACT [EC:1.1.1.25]
synonym: "shikimate:NADP(+) oxidoreductase activity" EXACT [EC:1.1.1.25]
xref: EC:1.1.1.25
xref: MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004765
name: shikimate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate." [EC:2.7.1.71]
subset: gosubset_prok
synonym: "ATP:shikimate 3-phosphotransferase activity" EXACT [EC:2.7.1.71]
synonym: "shikimate kinase (phosphorylating)" EXACT [EC:2.7.1.71]
synonym: "shikimate kinase II" RELATED [EC:2.7.1.71]
xref: EC:2.7.1.71
xref: MetaCyc:SHIKIMATE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0004766
name: spermidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine." [EC:2.5.1.16]
subset: gosubset_prok
synonym: "aminopropyltransferase activity" EXACT [EC:2.5.1.16]
synonym: "putrescine aminopropyltransferase activity" EXACT [EC:2.5.1.16]
synonym: "S-adenosylmethioninamine:putrescine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.16]
synonym: "SpeE" RELATED [EC:2.5.1.16]
synonym: "spermidine synthetase activity" EXACT [EC:2.5.1.16]
xref: EC:2.5.1.16
xref: MetaCyc:SPERMIDINESYN-RXN
xref: Reactome:14296 "spermidine synthase activity"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004767
name: sphingomyelin phosphodiesterase activity
namespace: molecular_function
alt_id: GO:0030230
alt_id: GO:0030231
def: "Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate." [EC:3.1.4.12]
subset: gosubset_prok
synonym: "acid sphingomyelin phosphodiesterase" NARROW []
synonym: "acid sphingomyelinase activity" NARROW [EC:3.1.4.12]
synonym: "neutral sphingomyelin phosphodiesterase" NARROW []
synonym: "neutral sphingomyelinase activity" NARROW [EC:3.1.4.12]
synonym: "sphingomyelin cholinephosphohydrolase activity" EXACT [EC:3.1.4.12]
synonym: "sphingomyelinase activity" EXACT []
xref: EC:3.1.4.12
xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN
xref: Reactome:14297 "sphingomyelin phosphodiesterase activity"
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0004768
name: stearoyl-CoA 9-desaturase activity
namespace: molecular_function
alt_id: GO:0016214
alt_id: GO:0043735
def: "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1]
comment: Note that this function was formerly EC:1.14.99.5.
subset: gosubset_prok
synonym: "acyl-CoA desaturase activity" EXACT [EC:1.14.19.1]
synonym: "delta(9)-desaturase activity" EXACT [EC:1.14.19.1]
synonym: "delta-9 acyl-phospholipid desaturase activity" RELATED []
synonym: "delta9-desaturase activity" EXACT [EC:1.14.19.1]
synonym: "fatty acid desaturase activity" EXACT [EC:1.14.19.1]
synonym: "stearoyl-CoA desaturase activity" EXACT []
synonym: "stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.1]
synonym: "stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating)" EXACT [EC:1.14.19.1]
xref: EC:1.14.19.1
xref: MetaCyc:1.14.19.1-RXN
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0004769
name: steroid delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid." [EC:5.3.3.1]
subset: gosubset_prok
synonym: "3-oxosteroid delta5-delta4-isomerase activity" EXACT [EC:5.3.3.1]
synonym: "3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta(5)-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta(5)-3-ketosteroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta(5)-3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta(5)-steroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta5(or delta4)-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta5-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta5-3-ketosteroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta5-3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta5-ketosteroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "delta5-steroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "hydroxysteroid isomerase activity" EXACT [EC:5.3.3.1]
synonym: "steroid D-isomerase activity" EXACT []
synonym: "steroid isomerase activity" EXACT [EC:5.3.3.1]
xref: EC:5.3.3.1
xref: MetaCyc:STEROID-DELTA-ISOMERASE-RXN
xref: Reactome:14301 "steroid delta-isomerase activity"
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0004770
name: sterol carrier protein X-related thiolase activity
namespace: molecular_function
xref: Reactome:14315 "sterol carrier protein X-related thiolase activity"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0004771
name: sterol esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13]
synonym: "acylcholesterol lipase activity" EXACT [EC:3.1.1.13]
synonym: "cholesterase activity" EXACT [EC:3.1.1.13]
synonym: "cholesterol ester hydrolase activity" EXACT [EC:3.1.1.13]
synonym: "cholesterol ester synthase activity" NARROW [EC:3.1.1.13]
synonym: "cholesterol esterase activity" NARROW [EC:3.1.1.13]
synonym: "cholesteryl ester hydrolase activity" EXACT [EC:3.1.1.13]
synonym: "cholesteryl ester synthase activity" EXACT [EC:3.1.1.13]
synonym: "cholesteryl esterase activity" EXACT [EC:3.1.1.13]
synonym: "sterol ester hydrolase activity" EXACT [EC:3.1.1.13]
synonym: "steryl-ester acylhydrolase activity" EXACT [EC:3.1.1.13]
synonym: "triterpenol esterase activity" EXACT [EC:3.1.1.13]
xref: EC:3.1.1.13
xref: MetaCyc:STEROL-ESTERASE-RXN
xref: Reactome:14316 "sterol esterase activity"
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0004772
name: sterol O-acyltransferase activity
namespace: molecular_function
alt_id: GO:0017066
def: "Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester." [EC:2.3.1.26, GOC:mah]
synonym: "sterol-ester synthase activity" EXACT [EC:2.3.1.26]
synonym: "sterol-ester synthetase activity" EXACT [EC:2.3.1.26]
xref: MetaCyc:STEROL-O-ACYLTRANSFERASE-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0004773
name: steryl-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + SO4(2-) (sulfate)." [EC:3.1.6.2]
synonym: "3-beta-hydroxysteroid sulfate sulfatase activity" EXACT [EC:3.1.6.2]
synonym: "arylsulfatase C activity" EXACT [EC:3.1.6.2]
synonym: "dehydroepiandrosterone sulfatase activity" EXACT [EC:3.1.6.2]
synonym: "dehydroepiandrosterone sulfate sulfatase activity" EXACT [EC:3.1.6.2]
synonym: "phenolic steroid sulfatase activity" EXACT [EC:3.1.6.2]
synonym: "pregnenolone sulfatase activity" EXACT [EC:3.1.6.2]
synonym: "steroid 3-sulfatase activity" EXACT [EC:3.1.6.2]
synonym: "steroid sulfatase activity" EXACT [EC:3.1.6.2]
synonym: "steroid sulfate sulfohydrolase activity" EXACT [EC:3.1.6.2]
synonym: "sterol sulfatase activity" EXACT [EC:3.1.6.2]
synonym: "steryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.2]
synonym: "steryl-sulphatase activity" EXACT []
xref: EC:3.1.6.2
xref: MetaCyc:STERYL-SULFATASE-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0004774
name: succinate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction between succinate and CoA to form succinyl-CoA." [EC:6.2.1.-, GOC:ai]
subset: gosubset_prok
xref: EC:6.2.1.-
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0004775
name: succinate-CoA ligase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [EC:6.2.1.5]
subset: gosubset_prok
synonym: "A-SCS" RELATED [EC:6.2.1.5]
synonym: "A-STK (adenin nucleotide-linked succinate thiokinase)" RELATED [EC:6.2.1.5]
synonym: "succinate thiokinase activity" EXACT [EC:6.2.1.5]
synonym: "succinate:CoA ligase (ADP-forming) activity" EXACT [EC:6.2.1.5]
synonym: "succinic thiokinase" BROAD [EC:6.2.1.5]
synonym: "succinyl coenzyme A synthetase" BROAD [EC:6.2.1.5]
synonym: "succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity" EXACT [EC:6.2.1.5]
synonym: "succinyl-CoA synthetase (ADP-forming) activity" EXACT [EC:6.2.1.5]
synonym: "succinyl-CoA synthetase activity" EXACT [EC:6.2.1.5]
xref: EC:6.2.1.5
xref: MetaCyc:SUCCCOASYN-RXN
xref: Reactome:14321 "succinate-CoA ligase (ADP-forming) activity"
is_a: GO:0004774 ! succinate-CoA ligase activity

[Term]
id: GO:0004776
name: succinate-CoA ligase (GDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate." [EC:6.2.1.4]
subset: gosubset_prok
synonym: "G-STK" RELATED [EC:6.2.1.4]
synonym: "P-enzyme" RELATED [EC:6.2.1.4]
synonym: "SCS" RELATED [EC:6.2.1.4]
synonym: "succinate-phosphorylating enzyme" RELATED [EC:6.2.1.4]
synonym: "succinate:CoA ligase (GDP-forming) activity" EXACT [EC:6.2.1.4]
synonym: "succinic thiokinase" BROAD [EC:6.2.1.4]
synonym: "succinyl CoA synthetase activity" EXACT [EC:6.2.1.4]
synonym: "succinyl coenzyme A synthetase" BROAD [EC:6.2.1.4]
synonym: "succinyl coenzyme A synthetase (GDP-forming) activity" EXACT [EC:6.2.1.4]
synonym: "succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity" EXACT [EC:6.2.1.4]
synonym: "succinyl-CoA synthetase (GDP-forming) activity" EXACT [EC:6.2.1.4]
xref: EC:6.2.1.4
xref: MetaCyc:SUCCINATE--COA-LIGASE-GDP-FORMING-RXN
xref: Reactome:14322 "succinate-CoA ligase (GDP-forming) activity"
is_a: GO:0004774 ! succinate-CoA ligase activity

[Term]
id: GO:0004777
name: succinate-semialdehyde dehydrogenase activity
namespace: molecular_function
alt_id: GO:0008952
def: "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [EC:1.2.1.24]
subset: gosubset_prok
synonym: "succinate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24]
synonym: "succinate semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24]
synonym: "succinate-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24]
synonym: "succinic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24]
synonym: "succinyl semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24]
xref: EC:1.2.1.24
xref: MetaCyc:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004778
name: succinyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + H2O = CoA + succinate." [EC:3.1.2.3]
synonym: "succinyl coenzyme A deacylase activity" EXACT [EC:3.1.2.3]
synonym: "succinyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.3]
synonym: "succinyl-CoA acylase activity" EXACT [EC:3.1.2.3]
xref: EC:3.1.2.3
xref: MetaCyc:SUCCINYL-COA-HYDROLASE-RXN
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0004779
name: sulfate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate." [GOC:mah, MetaCyc:SULFATE-ADENYLYLTRANS-RXN, MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN]
subset: gosubset_prok
synonym: "sulphate adenylyltransferase activity" EXACT []
xref: EC:2.7.7.-
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0004780
name: sulfate adenylyltransferase (ADP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + SO4(2-) (sulfate) = phosphate + adenylylsulfate." [EC:2.7.7.5]
synonym: "adenosine diphosphate sulfurylase activity" EXACT [EC:2.7.7.5]
synonym: "ADP-sulfurylase activity" EXACT [EC:2.7.7.5]
synonym: "ADP:sulfate adenylyltransferase activity" EXACT []
synonym: "sulfate (adenosine diphosphate) adenylyltransferase activity" EXACT [EC:2.7.7.5]
synonym: "sulphate adenylyltransferase (ADP) activity" EXACT []
xref: EC:2.7.7.5
xref: MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN
is_a: GO:0004779 ! sulfate adenylyltransferase activity

[Term]
id: GO:0004781
name: sulfate adenylyltransferase (ATP) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + SO4(2-) (sulfate) = diphosphate + adenylylsulfate." [EC:2.7.7.4]
subset: gosubset_prok
synonym: "adenosine-5'-triphosphate sulfurylase activity" EXACT [EC:2.7.7.4]
synonym: "adenosinetriphosphate sulfurylase activity" EXACT [EC:2.7.7.4]
synonym: "adenylylsulfate pyrophosphorylase activity" EXACT [EC:2.7.7.4]
synonym: "ATP sulfurylase activity" EXACT [EC:2.7.7.4]
synonym: "ATP-sulfurylase activity" EXACT [EC:2.7.7.4]
synonym: "ATP:sulfate adenylyltransferase activity" EXACT []
synonym: "sulfate adenylate transferase activity" EXACT [EC:2.7.7.4]
synonym: "sulfurylase activity" RELATED [EC:2.7.7.4]
synonym: "sulphate adenylyltransferase (ATP) activity" EXACT []
xref: EC:2.7.7.4
xref: MetaCyc:SULFATE-ADENYLYLTRANS-RXN
xref: Reactome:14341 "sulfate adenylyltransferase (ATP) activity"
is_a: GO:0004779 ! sulfate adenylyltransferase activity

[Term]
id: GO:0004782
name: sulfinoalanine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2." [EC:4.1.1.29]
synonym: "3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)" EXACT [EC:4.1.1.29]
synonym: "3-sulfino-L-alanine carboxy-lyase activity" EXACT [EC:4.1.1.29]
synonym: "CADCase/CSADCase activity" EXACT [EC:4.1.1.29]
synonym: "CSAD" RELATED [EC:4.1.1.29]
synonym: "CSADCase activity" EXACT [EC:4.1.1.29]
synonym: "cysteic decarboxylase activity" EXACT [EC:4.1.1.29]
synonym: "cysteine-sulfinate decarboxylase activity" EXACT [EC:4.1.1.29]
synonym: "cysteinesulfinate decarboxylase activity" EXACT [EC:4.1.1.29]
synonym: "cysteinesulfinic acid decarboxylase activity" EXACT [EC:4.1.1.29]
synonym: "L-cysteinesulfinic acid decarboxylase activity" EXACT [EC:4.1.1.29]
synonym: "sulfoalanine decarboxylase activity" EXACT [EC:4.1.1.29]
synonym: "sulphinoalanine decarboxylase activity" EXACT []
xref: EC:4.1.1.29
xref: MetaCyc:SULFINOALANINE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004783
name: sulfite reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: H2S + 3 NADP+ + 3 H2O = SO3(2-) (sulfite) + 3 NADPH + 3 H+." [EC:1.8.1.2]
subset: gosubset_prok
synonym: "H2S-NADP oxidoreductase activity" EXACT [EC:1.8.1.2]
synonym: "hydrogen-sulfide:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.2]
synonym: "NADPH-dependent sulfite reductase activity" EXACT [EC:1.8.1.2]
synonym: "NADPH-sulfite reductase activity" EXACT [EC:1.8.1.2]
synonym: "NADPH:sulfite reductase flavoprotein" RELATED []
synonym: "sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.8.1.2]
synonym: "sulphite reductase (NADPH) activity" EXACT []
xref: EC:1.8.1.2
xref: MetaCyc:SULFITE-REDUCT-RXN
is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004784
name: superoxide dismutase activity
namespace: molecular_function
alt_id: GO:0004785
alt_id: GO:0008382
alt_id: GO:0008383
alt_id: GO:0016954
def: "Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2." [EC:1.15.1.1]
subset: gosubset_prok
synonym: "copper, zinc superoxide dismutase activity" NARROW []
synonym: "Cu,Zn-SOD" RELATED [EC:1.15.1.1]
synonym: "Cu-Zn superoxide dismutase activity" NARROW [EC:1.15.1.1]
synonym: "cuprein" RELATED [EC:1.15.1.1]
synonym: "cytocuprein" RELATED [EC:1.15.1.1]
synonym: "erythrocuprein" RELATED [EC:1.15.1.1]
synonym: "Fe-SOD" RELATED [EC:1.15.1.1]
synonym: "ferrisuperoxide dismutase activity" NARROW [EC:1.15.1.1]
synonym: "hemocuprein" RELATED [EC:1.15.1.1]
synonym: "hepatocuprein" RELATED [EC:1.15.1.1]
synonym: "iron superoxide dismutase activity" NARROW []
synonym: "iron superoxide oxidoreductase" RELATED []
synonym: "manganese superoxide dismutase activity" NARROW []
synonym: "manganese superoxide oxidoreductase" RELATED []
synonym: "Mn, Fe superoxide dismutase" NARROW []
synonym: "Mn-SOD" RELATED [EC:1.15.1.1]
synonym: "nickel superoxide dismutase activity" NARROW []
synonym: "nickel superoxide oxidoreductase" RELATED []
synonym: "SOD" RELATED [EC:1.15.1.1]
synonym: "SOD-1" RELATED [EC:1.15.1.1]
synonym: "SOD-2" RELATED [EC:1.15.1.1]
synonym: "SOD-3" RELATED [EC:1.15.1.1]
synonym: "SOD-4" RELATED [EC:1.15.1.1]
synonym: "SODF" RELATED [EC:1.15.1.1]
synonym: "SODS" RELATED [EC:1.15.1.1]
synonym: "superoxide dismutase I" RELATED [EC:1.15.1.1]
synonym: "superoxide dismutase II" RELATED [EC:1.15.1.1]
synonym: "superoxide:superoxide oxidoreductase activity" EXACT []
synonym: "zinc superoxide oxidoreductase" RELATED []
xref: EC:1.15.1.1
xref: MetaCyc:SUPEROX-DISMUT-RXN
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor

[Term]
id: GO:0004786
name: Mn, Fe superoxide dismutase
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the function is covered by an existing term.
is_obsolete: true
consider: GO:0004784

[Term]
id: GO:0004787
name: thiamin-pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: TDP + H2O = TMP + phosphate." [EC:3.6.1.-, GOC:ai]
synonym: "thiamin pyrophosphatase activity" EXACT []
synonym: "thiamine pyrophosphatase activity" EXACT []
synonym: "thiaminpyrophosphatase activity" EXACT [EC:3.6.1.6]
synonym: "TPPase activity" EXACT []
xref: EC:3.6.1.-
is_a: GO:0017110 ! nucleoside-diphosphatase activity

[Term]
id: GO:0004788
name: thiamin diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thiamin = AMP + thiamin diphosphate." [EC:2.7.6.2]
subset: gosubset_prok
synonym: "ATP:thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2]
synonym: "ATP:thiamine diphosphotransferase activity" EXACT [EC:2.7.6.2]
synonym: "thiamin pyrophosphokinase activity" EXACT []
synonym: "thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2]
synonym: "thiamin:ATP pyrophosphotransferase activity" EXACT [EC:2.7.6.2]
synonym: "thiamine diphosphokinase activity" EXACT [EC:2.7.6.2]
synonym: "thiamine pyrophosphokinase activity" EXACT []
synonym: "thiaminokinase activity" EXACT [EC:2.7.6.2]
synonym: "TPTase activity" EXACT [EC:2.7.6.2]
xref: EC:2.7.6.2
xref: MetaCyc:THIAMIN-PYROPHOSPHOKINASE-RXN
xref: Reactome:14348 "thiamin diphosphokinase activity"
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0004789
name: thiamin-phosphate diphosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-4-methyl-5-(2-phosphonooxyethyl)-thiazole = diphosphate + thiamin monophosphate." [EC:2.5.1.3]
subset: gosubset_prok
synonym: "2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.3]
synonym: "thiamin-phosphate pyrophosphorylase activity" EXACT []
synonym: "thiamine monophosphate pyrophosphorylase activity" EXACT [EC:2.5.1.3]
synonym: "thiamine phosphate pyrophosphorylase activity" EXACT [EC:2.5.1.3]
synonym: "thiamine-phosphate diphosphorylase activity" EXACT [EC:2.5.1.3]
synonym: "thiamine-phosphate pyrophosphorylase activity" EXACT []
synonym: "thiamine-phosphate synthase activity" EXACT [EC:2.5.1.3]
synonym: "TMP diphosphorylase activity" EXACT [EC:2.5.1.3]
synonym: "TMP pyrophosphorylase activity" EXACT [EC:2.5.1.3]
synonym: "TMP-PPase activity" EXACT [EC:2.5.1.3]
xref: EC:2.5.1.3
xref: MetaCyc:THI-P-SYN-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004790
name: thioether S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium." [EC:2.1.1.96]
synonym: "S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase activity" EXACT [EC:2.1.1.96]
synonym: "S-adenosyl-L-methionine:thioether S-methyltransferase activity" EXACT [EC:2.1.1.96]
synonym: "thioether methyltransferase activity" EXACT [EC:2.1.1.96]
xref: EC:2.1.1.96
xref: MetaCyc:THIOETHER-S-METHYLTRANSFERASE-RXN
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004791
name: thioredoxin-disulfide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+." [EC:1.8.1.9, ISBN:0198547684]
subset: gosubset_prok
synonym: "NADP--thioredoxin reductase activity" EXACT [EC:1.8.1.9]
synonym: "NADPH--thioredoxin reductase activity" EXACT [EC:1.8.1.9]
synonym: "NADPH2:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9]
synonym: "NADPH:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9]
synonym: "thioredoxin disulfide reductase activity" EXACT []
synonym: "thioredoxin reductase (NADPH) activity" EXACT []
synonym: "thioredoxin-disulphide reductase activity" EXACT []
synonym: "thioredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.9]
xref: EC:1.8.1.9
xref: MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN
xref: Reactome:14367 "thioredoxin-disulfide reductase activity"
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor

[Term]
id: GO:0004792
name: thiosulfate sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiosulfate + cyanide = SO3(2-) (sulfite) + thiocyanate." [EC:2.8.1.1]
subset: gosubset_prok
synonym: "rhodanase activity" EXACT [EC:2.8.1.1]
synonym: "rhodanese activity" RELATED [EC:2.8.1.1]
synonym: "thiosulfate cyanide transsulfurase activity" EXACT [EC:2.8.1.1]
synonym: "thiosulfate thiotransferase activity" EXACT [EC:2.8.1.1]
synonym: "thiosulfate:cyanide sulfurtransferase activity" EXACT [EC:2.8.1.1]
synonym: "thiosulphate sulphurtransferase activity" EXACT []
xref: EC:2.8.1.1
xref: MetaCyc:THIOSULFATE-SULFURTRANSFERASE-RXN
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0004793
name: threonine aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine = glycine + acetaldehyde." [EC:4.1.2.5]
subset: gosubset_prok
synonym: "L-threonine acetaldehyde-lyase (glycine-forming)" EXACT [EC:4.1.2.5]
synonym: "L-threonine acetaldehyde-lyase activity" EXACT [EC:4.1.2.5]
synonym: "L-threonine aldolase activity" EXACT []
xref: EC:4.1.2.5
xref: MetaCyc:THREONINE-ALDOLASE-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0004794
name: L-threonine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3." [EC:4.3.1.19]
comment: Note that this function was formerly EC:4.2.1.16.
subset: gosubset_prok
synonym: "L-serine dehydratase activity" RELATED [EC:4.3.1.19]
synonym: "L-threonine ammonia-lyase (2-oxobutanoate-forming)" EXACT [EC:4.3.1.19]
synonym: "L-threonine deaminase activity" EXACT [EC:4.3.1.19]
synonym: "L-threonine dehydratase activity" EXACT [EC:4.3.1.19]
synonym: "L-threonine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.19]
synonym: "serine deaminase activity" RELATED [EC:4.3.1.19]
synonym: "threonine ammonia-lyase activity" EXACT []
synonym: "threonine deaminase activity" EXACT [EC:4.3.1.19]
synonym: "threonine dehydrase activity" EXACT [EC:4.3.1.19]
synonym: "threonine dehydratase activity" EXACT []
xref: EC:4.3.1.19
xref: MetaCyc:THREDEHYD-RXN
xref: UM-BBD_enzymeID:e0306
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0004795
name: threonine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate." [EC:4.2.3.1]
subset: gosubset_prok
synonym: "O-phospho-L-homoserine phospho-lyase (adding water)" EXACT [EC:4.2.3.1]
synonym: "O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)" EXACT [EC:4.2.3.1]
synonym: "threonine synthetase activity" EXACT [EC:4.2.3.1]
xref: EC:4.2.3.1
xref: MetaCyc:THRESYN-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0004796
name: thromboxane-A synthase activity
namespace: molecular_function
alt_id: GO:0008400
def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromba-5,13-dienoate." [EC:5.3.99.5]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity" EXACT [EC:5.3.99.5]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity" EXACT [EC:5.3.99.5]
synonym: "cytochrome P450 CYP5" NARROW []
synonym: "thromboxane synthase activity" EXACT [EC:5.3.99.5]
synonym: "thromboxane synthetase activity" EXACT [EC:5.3.99.5]
xref: EC:5.3.99.5
xref: MetaCyc:THROMBOXANE-A-SYNTHASE-RXN
xref: Reactome:14373 "thromboxane-A synthase activity"
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0004797
name: thymidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate." [EC:2.7.1.21]
subset: gosubset_prok
synonym: "2'-deoxythymidine kinase activity" EXACT [EC:2.7.1.21]
synonym: "ATP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.21]
synonym: "deoxythymidine kinase (phosphorylating)" EXACT [EC:2.7.1.21]
synonym: "thymidine kinase (phosphorylating)" EXACT [EC:2.7.1.21]
xref: EC:2.7.1.21
xref: MetaCyc:THYKI-RXN
is_a: GO:0019136 ! deoxynucleoside kinase activity

[Term]
id: GO:0004798
name: thymidylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate." [EC:2.7.4.9]
subset: gosubset_prok
synonym: "ATP:dTMP phosphotransferase activity" EXACT [EC:2.7.4.9]
synonym: "deoxythymidine 5'-monophosphate kinase activity" EXACT [EC:2.7.4.9]
synonym: "dTMP kinase activity" EXACT []
synonym: "thymidine 5'-monophosphate kinase activity" EXACT [EC:2.7.4.9]
synonym: "thymidine monophosphate kinase activity" EXACT [EC:2.7.4.9]
synonym: "thymidylate monophosphate kinase activity" EXACT [EC:2.7.4.9]
synonym: "thymidylic acid kinase activity" EXACT [EC:2.7.4.9]
synonym: "thymidylic kinase activity" EXACT [EC:2.7.4.9]
synonym: "TMPK activity" EXACT [EC:2.7.4.9]
xref: EC:2.7.4.9
xref: MetaCyc:DTMPKI-RXN
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019201 ! nucleotide kinase activity

[Term]
id: GO:0004799
name: thymidylate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP." [EC:2.1.1.45]
subset: gosubset_prok
synonym: "5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.45]
synonym: "dTMP synthase activity" EXACT [EC:2.1.1.45]
synonym: "methylenetetrahydrofolate:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.45]
synonym: "thymidylate synthetase activity" EXACT [EC:2.1.1.45]
synonym: "TMP synthetase activity" EXACT [EC:2.1.1.45]
xref: EC:2.1.1.45
xref: MetaCyc:THYMIDYLATESYN-RXN
xref: Reactome:14376 "thymidylate synthase activity"
is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity

[Term]
id: GO:0004800
name: thyroxine 5'-deiodinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2." [EC:1.97.1.10]
comment: Note that this was EC:3.8.1.4.
synonym: "acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)" EXACT [EC:1.97.1.10]
synonym: "diiodothyronine 5'-deiodinase activity" EXACT [EC:1.97.1.10]
synonym: "iodothyronine 5'-deiodinase activity" EXACT [EC:1.97.1.10]
synonym: "iodothyronine outer ring monodeiodinase activity" EXACT [EC:1.97.1.10]
synonym: "L-thyroxine iodohydrolase (reducing) activity" EXACT [EC:1.97.1.10]
synonym: "thyroxine 5' deiodinase activity" EXACT []
synonym: "thyroxine deiodinase activity" BROAD []
synonym: "type I iodothyronine deiodinase activity" NARROW [EC:1.97.1.10]
synonym: "type II iodothyronine deiodinase activity" NARROW [EC:1.97.1.10]
xref: EC:1.97.1.10
xref: MetaCyc:THYROXINE-DEIODINASE-RXN
xref: Reactome:15048 "thyroxine 5'-deiodinase activity"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0004801
name: transaldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [EC:2.2.1.2]
subset: gosubset_prok
synonym: "dihydroxyacetone transferase activity" EXACT [EC:2.2.1.2]
synonym: "dihydroxyacetonetransferase activity" EXACT [EC:2.2.1.2]
synonym: "glycerone transferase activity" EXACT [EC:2.2.1.2]
synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity" EXACT [EC:2.2.1.2]
xref: EC:2.2.1.2
xref: MetaCyc:TRANSALDOL-RXN
xref: Reactome:15049 "transaldolase activity"
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0004802
name: transketolase activity
namespace: molecular_function
def: "Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor." [EC:2.2.1.1, GOC:fmc]
subset: gosubset_prok
synonym: "fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" NARROW [GOC:fmc, GOC:mah]
synonym: "glycoaldehyde transferase activity" EXACT [EC:2.2.1.1]
synonym: "glycolaldehydetransferase activity" EXACT [EC:2.2.1.1]
synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" NARROW [EC:2.2.1.1]
xref: EC:2.2.1.1
xref: MetaCyc:1TRANSKETO-RXN
xref: Reactome:15050 "transketolase activity"
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0004803
name: transposase activity
namespace: molecular_function
def: "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in site-specific DNA recombination required for transposition in bacteria and other organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0004804
name: P-element encoded transposase activity
namespace: molecular_function
is_a: GO:0004803 ! transposase activity

[Term]
id: GO:0004805
name: trehalose-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate." [EC:3.1.3.12]
subset: gosubset_prok
synonym: "trehalose 6-phosphatase activity" EXACT [EC:3.1.3.12]
synonym: "trehalose 6-phosphate phosphatase activity" EXACT [EC:3.1.3.12]
synonym: "trehalose phosphatase activity" EXACT []
synonym: "trehalose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.12]
xref: EC:3.1.3.12
xref: MetaCyc:TREHALOSEPHOSPHA-RXN
is_a: GO:0019203 ! carbohydrate phosphatase activity

[Term]
id: GO:0004806
name: triglyceride lipase activity
namespace: molecular_function
def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion." [EC:3.1.1.3]
subset: gosubset_prok
synonym: "amano AP" RELATED [EC:3.1.1.3]
synonym: "amano B" RELATED [EC:3.1.1.3]
synonym: "amano CE" RELATED [EC:3.1.1.3]
synonym: "amano CES" RELATED [EC:3.1.1.3]
synonym: "amano P" RELATED [EC:3.1.1.3]
synonym: "amno N-AP" RELATED [EC:3.1.1.3]
synonym: "butyrinase activity" EXACT [EC:3.1.1.3]
synonym: "cacordase activity" EXACT [EC:3.1.1.3]
synonym: "capalase L" RELATED [EC:3.1.1.3]
synonym: "GA 56" RELATED [EC:3.1.1.3]
synonym: "GEH" RELATED [EC:3.1.1.3]
synonym: "glycerol ester hydrolase activity" EXACT [EC:3.1.1.3]
synonym: "glycerol-ester hydrolase activity" EXACT [EC:3.1.1.3]
synonym: "heparin releasable hepatic lipase" NARROW [EC:3.1.1.3]
synonym: "hepatic lipase" NARROW [EC:3.1.1.3]
synonym: "hepatic monoacylglycerol acyltransferase" NARROW [EC:3.1.1.3]
synonym: "lipazin" RELATED [EC:3.1.1.3]
synonym: "liver lipase" NARROW [EC:3.1.1.3]
synonym: "meito MY 30" RELATED [EC:3.1.1.3]
synonym: "meito sangyo OF lipase" RELATED [EC:3.1.1.3]
synonym: "post-heparin plasma protamine-resistant lipase" NARROW [EC:3.1.1.3]
synonym: "PPL" RELATED [EC:3.1.1.3]
synonym: "salt-resistant post-heparin lipase" NARROW [EC:3.1.1.3]
synonym: "steapsin" RELATED [EC:3.1.1.3]
synonym: "takedo 1969-4-9" RELATED [EC:3.1.1.3]
synonym: "triacetinase activity" EXACT [EC:3.1.1.3]
synonym: "triacylglycerol acylhydrolase activity" EXACT [EC:3.1.1.3]
synonym: "triacylglycerol ester hydrolase activity" EXACT [EC:3.1.1.3]
synonym: "triacylglycerol lipase activity" EXACT [EC:3.1.1.3]
synonym: "tributyrase activity" RELATED [EC:3.1.1.3]
synonym: "tributyrin esterase activity" EXACT [EC:3.1.1.3]
synonym: "tributyrinase activity" EXACT [EC:3.1.1.3]
synonym: "triglyceridase activity" EXACT [EC:3.1.1.3]
synonym: "triglyceride hydrolase activity" EXACT [EC:3.1.1.3]
synonym: "triolein hydrolase activity" EXACT [EC:3.1.1.3]
synonym: "tween hydrolase activity" EXACT [EC:3.1.1.3]
synonym: "tween-hydrolyzing esterase activity" EXACT [EC:3.1.1.3]
synonym: "tweenase activity" EXACT [EC:3.1.1.3]
synonym: "tweenesterase activity" EXACT [EC:3.1.1.3]
xref: EC:3.1.1.3
xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN
xref: Reactome:15058 "triacylglycerol lipase activity"
is_a: GO:0004091 ! carboxylesterase activity
is_a: GO:0016298 ! lipase activity

[Term]
id: GO:0004807
name: triose-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate." [EC:5.3.1.1]
subset: gosubset_prok
synonym: "D-glyceraldehyde-3-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.1]
synonym: "D-glyceraldehyde-3-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.1]
synonym: "phosphotriose isomerase activity" EXACT [EC:5.3.1.1]
synonym: "triose phosphate mutase activity" EXACT [EC:5.3.1.1]
synonym: "triose phosphoisomerase activity" EXACT [EC:5.3.1.1]
synonym: "triosephosphate isomerase activity" EXACT [EC:5.3.1.1]
synonym: "triosephosphate mutase activity" EXACT [EC:5.3.1.1]
xref: EC:5.3.1.1
xref: MetaCyc:TRIOSEPISOMERIZATION-RXN
xref: Reactome:70450 "triose-phosphate isomerase activity"
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0004808
name: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
namespace: molecular_function
alt_id: GO:0016425
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate." [EC:2.1.1.61]
subset: gosubset_prok
synonym: "S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity" EXACT [EC:2.1.1.61]
synonym: "transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity" EXACT [EC:2.1.1.61]
synonym: "tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity" EXACT [EC:2.1.1.61]
xref: EC:2.1.1.61
xref: MetaCyc:2.1.1.61-RXN
is_a: GO:0008175 ! tRNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004809
name: tRNA (guanine-N2-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [EC:2.1.1.32]
subset: gosubset_prok
synonym: "guanine-N2-methylase activity" EXACT [EC:2.1.1.32]
synonym: "N(2),N(2)-dimethylguanine tRNA methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "N2,N2-dimethylguanine tRNA methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "S-adenosyl-L-methionine:tRNA (guanine-2-N-)-methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "S-adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "transfer ribonucleate guanine 2-methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "transfer ribonucleate guanine N2-methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "transfer RNA guanine 2-methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "tRNA 2,2-dimethylguanosine-26 methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "tRNA(guanine-26,N(2)-N(2)) methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "tRNA(guanine-26,N2-N2) methyltransferase activity" EXACT [EC:2.1.1.32]
synonym: "tRNA(m(2,2)G26)dimethyltransferase activity" EXACT [EC:2.1.1.32]
xref: EC:2.1.1.32
xref: MetaCyc:TRNA-GUANINE-N2--METHYLTRANSFERASE-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0004810
name: tRNA adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1)." [EC:2.7.7.25]
subset: gosubset_prok
synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.25]
synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25]
synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25]
synonym: "ATP:tRNA adenylyltransferase activity" EXACT []
synonym: "CCA-adding enzyme activity" RELATED [EC:2.7.7.25]
synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25]
synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.25]
synonym: "ribonucleic cytidylyltransferase" BROAD [EC:2.7.7.25]
synonym: "transfer ribonucleate adenyltransferase activity" EXACT [EC:2.7.7.25]
synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.25]
synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.25]
synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [EC:2.7.7.25]
synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [EC:2.7.7.25]
synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.25]
synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [EC:2.7.7.25]
synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.25]
synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.25]
synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.25]
synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.25]
synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.25]
synonym: "tRNA-nucleotidyltransferase activity" BROAD [EC:2.7.7.25]
xref: EC:2.7.7.25
xref: MetaCyc:TRNA-ADENYLYLTRANSFERASE-RXN
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0004811
name: tRNA isopentenyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: isopentenyl diphosphate + tRNA = diphosphate + tRNA containing 6-isopentenyladenosine." [EC:2.5.1.8]
subset: gosubset_prok
synonym: "delta2-isopentenyl pyrophosphate:transfer ribonucleic acid delta2-isopentenyltransferase activity" EXACT [EC:2.5.1.8]
synonym: "delta2-isopentenyl pyrophosphate:tRNA-delta2-isopentenyl transferase activity" EXACT [EC:2.5.1.8]
synonym: "IPP transferase activity" EXACT [EC:2.5.1.8]
synonym: "isopentenyl-diphosphate:tRNA isopentenyltransferase activity" EXACT [EC:2.5.1.8]
synonym: "transfer ribonucleate isopentenyltransferase activity" EXACT [EC:2.5.1.8]
xref: EC:2.5.1.8
xref: MetaCyc:TRNA-ISOPENTENYLTRANSFERASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0004812
name: aminoacyl-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA.
subset: gosubset_prok
synonym: "aminoacyl-tRNA synthetase activity" EXACT [GOC:hjd]
xref: EC:6.1.1.-
is_a: GO:0016876 ! ligase activity, forming aminoacyl-tRNA and related compounds

[Term]
id: GO:0004813
name: alanine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7]
subset: gosubset_prok
synonym: "Ala-tRNA synthetase activity" EXACT [EC:6.1.1.7]
synonym: "alanine transfer RNA synthetase activity" EXACT [EC:6.1.1.7]
synonym: "alanine translase activity" EXACT [EC:6.1.1.7]
synonym: "alanine tRNA synthetase activity" EXACT [EC:6.1.1.7]
synonym: "alanine-transfer RNA ligase activity" EXACT [EC:6.1.1.7]
synonym: "alanyl-transfer ribonucleate synthase activity" EXACT [EC:6.1.1.7]
synonym: "alanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.7]
synonym: "alanyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.7]
synonym: "alanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.7]
synonym: "alanyl-tRNA synthetase activity" EXACT []
synonym: "AlaRS" RELATED [EC:6.1.1.7]
synonym: "L-alanine:tRNAAla ligase (AMP-forming)" EXACT [EC:6.1.1.7]
xref: EC:6.1.1.7
xref: MetaCyc:ALANINE--TRNA-LIGASE-RXN
xref: Reactome:15078 "alanine-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004814
name: arginine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19]
subset: gosubset_prok
synonym: "arginine translase activity" EXACT [EC:6.1.1.19]
synonym: "arginine-tRNA synthetase activity" EXACT [EC:6.1.1.19]
synonym: "arginyl transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.19]
synonym: "arginyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.19]
synonym: "arginyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.19]
synonym: "arginyl-tRNA synthetase activity" EXACT []
synonym: "L-arginine:tRNAArg ligase (AMP-forming)" EXACT [EC:6.1.1.19]
xref: EC:6.1.1.19
xref: MetaCyc:ARGININE--TRNA-LIGASE-RXN
xref: Reactome:15079 "arginine-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004815
name: aspartate-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)." [EC:6.1.1.12]
subset: gosubset_prok
synonym: "aspartic acid translase activity" EXACT [EC:6.1.1.12]
synonym: "aspartyl ribonucleate synthetase activity" EXACT [EC:6.1.1.12]
synonym: "aspartyl ribonucleic synthetase activity" EXACT [EC:6.1.1.12]
synonym: "aspartyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.12]
synonym: "aspartyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.12]
synonym: "aspartyl-tRNA synthetase activity" EXACT []
synonym: "L-aspartate:tRNAAsp ligase (AMP-forming)" EXACT [EC:6.1.1.12]
xref: EC:6.1.1.12
xref: MetaCyc:ASPARTATE--TRNA-LIGASE-RXN
xref: Reactome:15081 "aspartate-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004816
name: asparagine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)." [EC:6.1.1.22]
subset: gosubset_prok
synonym: "asparagine translase activity" EXACT [EC:6.1.1.22]
synonym: "asparaginyl transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.22]
synonym: "asparaginyl transfer RNA synthetase activity" EXACT [EC:6.1.1.22]
synonym: "asparaginyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.22]
synonym: "asparaginyl-tRNA synthetase activity" EXACT []
synonym: "asparagyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.22]
synonym: "L-asparagine:tRNAAsn ligase (AMP-forming)" EXACT [EC:6.1.1.22]
xref: EC:6.1.1.22
xref: MetaCyc:ASPARAGINE--TRNA-LIGASE-RXN
xref: Reactome:15083 "asparagine-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004817
name: cysteine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." [EC:6.1.1.16]
subset: gosubset_prok
synonym: "cysteine translase activity" EXACT [EC:6.1.1.16]
synonym: "cysteinyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.16]
synonym: "cysteinyl-transferRNA synthetase activity" EXACT [EC:6.1.1.16]
synonym: "cysteinyl-tRNA synthetase activity" EXACT []
synonym: "L-cysteine:tRNACys ligase (AMP-forming)" EXACT [EC:6.1.1.16]
xref: EC:6.1.1.16
xref: MetaCyc:CYSTEINE--TRNA-LIGASE-RXN
xref: Reactome:15084 "cysteine-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004818
name: glutamate-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17]
subset: gosubset_prok
synonym: "glutamate-tRNA synthetase activity" EXACT [EC:6.1.1.17]
synonym: "glutamic acid translase activity" EXACT [EC:6.1.1.17]
synonym: "glutamyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.17]
synonym: "glutamyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.17]
synonym: "glutamyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.17]
synonym: "glutamyl-tRNA synthetase activity" EXACT []
synonym: "L-glutamate:tRNAGlu ligase (AMP-forming) activity" EXACT [EC:6.1.1.17]
xref: EC:6.1.1.17
xref: MetaCyc:GLURS-RXN
xref: Reactome:15085 "glutamate-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004819
name: glutamine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18]
subset: gosubset_prok
synonym: "GlnRS" RELATED [EC:6.1.1.18]
synonym: "glutamine translase activity" EXACT [EC:6.1.1.18]
synonym: "glutamine-tRNA synthetase activity" EXACT [EC:6.1.1.18]
synonym: "glutaminyl ribonucleic acid" RELATED [EC:6.1.1.18]
synonym: "glutaminyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.18]
synonym: "glutaminyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.18]
synonym: "glutaminyl-tRNA synthetase activity" EXACT []
synonym: "L-glutamine:tRNAGln ligase (AMP-forming)" EXACT [EC:6.1.1.18]
xref: EC:6.1.1.18
xref: MetaCyc:GLUTAMINE--TRNA-LIGASE-RXN
xref: Reactome:15087 "glutamine-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004820
name: glycine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)." [EC:6.1.1.14]
subset: gosubset_prok
synonym: "glycine:tRNAGly ligase (AMP-forming) activity" EXACT [EC:6.1.1.14]
synonym: "glycyl translase activity" EXACT [EC:6.1.1.14]
synonym: "glycyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.14]
synonym: "glycyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.14]
synonym: "glycyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.14]
synonym: "glycyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.14
xref: MetaCyc:GLYCINE--TRNA-LIGASE-RXN
xref: Reactome:15097 "glycine-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004821
name: histidine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)." [EC:6.1.1.21]
subset: gosubset_prok
synonym: "histidine translase activity" EXACT [EC:6.1.1.21]
synonym: "histidyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.21]
synonym: "histidyl-tRNA synthetase activity" EXACT []
synonym: "L-histidine:tRNAHis ligase (AMP-forming)" EXACT [EC:6.1.1.21]
xref: EC:6.1.1.21
xref: MetaCyc:HISTIDINE--TRNA-LIGASE-RXN
xref: Reactome:15098 "histidine-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004822
name: isoleucine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)." [EC:6.1.1.5]
subset: gosubset_prok
synonym: "isoleucine translase activity" EXACT [EC:6.1.1.5]
synonym: "isoleucine-transfer RNA ligase activity" EXACT [EC:6.1.1.5]
synonym: "isoleucine-tRNA synthetase activity" EXACT [EC:6.1.1.5]
synonym: "isoleucyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.5]
synonym: "isoleucyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.5]
synonym: "isoleucyl-tRNA synthetase activity" EXACT []
synonym: "L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [EC:6.1.1.5]
xref: EC:6.1.1.5
xref: MetaCyc:ISOLEUCINE--TRNA-LIGASE-RXN
xref: Reactome:15099 "isoleucine-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004823
name: leucine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)." [EC:6.1.1.4]
subset: gosubset_prok
synonym: "L-leucine:tRNALeu ligase (AMP-forming)" EXACT [EC:6.1.1.4]
synonym: "leucine translase activity" EXACT [EC:6.1.1.4]
synonym: "leucine-tRNA synthetase activity" EXACT [EC:6.1.1.4]
synonym: "leucyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.4]
synonym: "leucyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.4]
synonym: "leucyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.4]
synonym: "leucyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.4
xref: MetaCyc:LEUCINE--TRNA-LIGASE-RXN
xref: Reactome:15100 "leucine-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004824
name: lysine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)." [EC:6.1.1.6]
subset: gosubset_prok
synonym: "L-lysine-transfer RNA ligase activity" EXACT [EC:6.1.1.6]
synonym: "L-lysine:tRNALys ligase (AMP-forming)" EXACT [EC:6.1.1.6]
synonym: "lysine translase activity" EXACT [EC:6.1.1.6]
synonym: "lysine-tRNA synthetase activity" EXACT [EC:6.1.1.6]
synonym: "lysyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.6]
synonym: "lysyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.6]
synonym: "lysyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.6
xref: MetaCyc:LYSINE--TRNA-LIGASE-RXN
xref: Reactome:15101 "lysine-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004825
name: methionine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [EC:6.1.1.10]
subset: gosubset_prok
synonym: "L-methionine:tRNAMet ligase (AMP-forming)" EXACT [EC:6.1.1.10]
synonym: "methionine translase activity" EXACT [EC:6.1.1.10]
synonym: "methionyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.10]
synonym: "methionyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.10]
synonym: "methionyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.10]
synonym: "methionyl-tRNA synthetase activity" EXACT []
synonym: "MetRS activity" EXACT [EC:6.1.1.10]
xref: EC:6.1.1.10
xref: MetaCyc:METHIONINE--TRNA-LIGASE-RXN
xref: Reactome:15102 "methionine-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004826
name: phenylalanine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]
subset: gosubset_prok
synonym: "L-phenylalanine:tRNAPhe ligase (AMP-forming) activity" EXACT [EC:6.1.1.20]
synonym: "L-phenylalanyl-tRNA synthetase activity" EXACT [EC:6.1.1.20]
synonym: "phenylalanine translase activity" EXACT [EC:6.1.1.20]
synonym: "phenylalanine-tRNA synthetase activity" EXACT [EC:6.1.1.20]
synonym: "phenylalanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.20]
synonym: "phenylalanyl-transfer RNA ligase activity" EXACT [EC:6.1.1.20]
synonym: "phenylalanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.20]
synonym: "phenylalanyl-tRNA ligase activity" EXACT [EC:6.1.1.20]
synonym: "phenylalanyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.20
xref: MetaCyc:PHENYLALANINE--TRNA-LIGASE-RXN
xref: Reactome:15104 "phenylalanine-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004827
name: proline-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [EC:6.1.1.15]
subset: gosubset_prok
synonym: "L-proline:tRNAPro ligase (AMP-forming)" EXACT [EC:6.1.1.15]
synonym: "proline translase activity" EXACT [EC:6.1.1.15]
synonym: "prolinyl-tRNA ligase activity" EXACT [EC:6.1.1.15]
synonym: "prolyl-s-RNA synthetase activity" EXACT [EC:6.1.1.15]
synonym: "prolyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.15]
synonym: "prolyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.15]
synonym: "prolyl-transferRNA synthetase activity" EXACT [EC:6.1.1.15]
synonym: "prolyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.15
xref: MetaCyc:PROLINE--TRNA-LIGASE-RXN
xref: Reactome:15107 "proline-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004828
name: serine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11]
subset: gosubset_prok
synonym: "L-serine:tRNASer ligase (AMP-forming)" EXACT [EC:6.1.1.11]
synonym: "serine translase activity" EXACT [EC:6.1.1.11]
synonym: "SerRS activity" EXACT [EC:6.1.1.11]
synonym: "seryl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.11]
synonym: "seryl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.11]
synonym: "seryl-transfer RNA synthetase activity" EXACT [EC:6.1.1.11]
synonym: "seryl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.11
xref: MetaCyc:SERINE--TRNA-LIGASE-RXN
xref: Reactome:15110 "serine-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004829
name: threonine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)." [EC:6.1.1.3]
subset: gosubset_prok
synonym: "L-threonine:tRNAThr ligase (AMP-forming)" EXACT [EC:6.1.1.3]
synonym: "threonine translase activity" EXACT [EC:6.1.1.3]
synonym: "threonine-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.3]
synonym: "threonyl ribonucleic synthetase activity" EXACT [EC:6.1.1.3]
synonym: "threonyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.3]
synonym: "threonyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.3]
synonym: "threonyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.3]
synonym: "threonyl-tRNA synthetase activity" EXACT []
synonym: "TRS" RELATED [EC:6.1.1.3]
xref: EC:6.1.1.3
xref: MetaCyc:THREONINE--TRNA-LIGASE-RXN
xref: Reactome:15113 "threonine-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004830
name: tryptophan-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2]
subset: gosubset_prok
synonym: "L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity" EXACT [EC:6.1.1.2]
synonym: "L-tryptophan-tRNATrp ligase (AMP-forming)" EXACT [EC:6.1.1.2]
synonym: "L-tryptophan:tRNATrp ligase (AMP-forming)" EXACT [EC:6.1.1.2]
synonym: "TrpRS activity" EXACT [EC:6.1.1.2]
synonym: "tryptophan translase activity" EXACT [EC:6.1.1.2]
synonym: "tryptophanyl ribonucleic synthetase activity" EXACT [EC:6.1.1.2]
synonym: "tryptophanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.2]
synonym: "tryptophanyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.2]
synonym: "tryptophanyl-transfer ribonucleic synthetase activity" EXACT [EC:6.1.1.2]
synonym: "tryptophanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.2]
synonym: "tryptophanyl-tRNA synthase activity" EXACT [EC:6.1.1.2]
synonym: "tryptophanyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.2
xref: MetaCyc:TRYPTOPHAN--TRNA-LIGASE-RXN
xref: Reactome:15130 "tryptophan-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004831
name: tyrosine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)." [EC:6.1.1.1]
subset: gosubset_prok
synonym: "L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity" EXACT [EC:6.1.1.1]
synonym: "L-tyrosine-tRNATyr ligase (AMP-forming)" EXACT [EC:6.1.1.1]
synonym: "L-tyrosine:tRNATyr ligase (AMP-forming)" EXACT [EC:6.1.1.1]
synonym: "tyrosine translase activity" EXACT [EC:6.1.1.1]
synonym: "tyrosine tRNA synthetase activity" EXACT [EC:6.1.1.1]
synonym: "tyrosine-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.1]
synonym: "tyrosine-transfer RNA ligase activity" EXACT [EC:6.1.1.1]
synonym: "tyrosyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.1]
synonym: "tyrosyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.1]
synonym: "tyrosyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.1]
synonym: "tyrosyl-tRNA ligase activity" EXACT [EC:6.1.1.1]
synonym: "tyrosyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.1
xref: MetaCyc:TYROSINE--TRNA-LIGASE-RXN
xref: Reactome:15131 "tyrosine-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004832
name: valine-tRNA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)." [EC:6.1.1.9]
subset: gosubset_prok
synonym: "L-valine:tRNAVal ligase (AMP-forming)" EXACT [EC:6.1.1.9]
synonym: "valine transfer ribonucleate ligase activity" EXACT [EC:6.1.1.9]
synonym: "valine translase activity" EXACT [EC:6.1.1.9]
synonym: "valyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.9]
synonym: "valyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.9]
synonym: "valyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.9]
synonym: "valyl-tRNA synthetase activity" EXACT []
xref: EC:6.1.1.9
xref: MetaCyc:VALINE--TRNA-LIGASE-RXN
xref: Reactome:15132 "valine-tRNA ligase activity"
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0004833
name: tryptophan 2,3-dioxygenase activity
namespace: molecular_function
alt_id: GO:0004426
def: "Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.11]
subset: gosubset_prok
synonym: "indolamine 2,3-dioxygenase activity" BROAD [EC:1.13.11.11]
synonym: "indoleamine-pyrrole 2,3-dioxygenase activity" EXACT []
synonym: "L-tryptophan 2,3-dioxygenase activity" EXACT [EC:1.13.11.11]
synonym: "L-tryptophan pyrrolase activity" EXACT [EC:1.13.11.11]
synonym: "L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.11]
synonym: "TDO" RELATED [EC:1.13.11.11]
synonym: "tryptamin 2,3-dioxygenase activity" EXACT [EC:1.13.11.11]
synonym: "tryptamine 2,3-dioxygenase activity" EXACT [EC:1.13.11.11]
synonym: "tryptophan oxygenase activity" BROAD [EC:1.13.11.11]
synonym: "tryptophan peroxidase activity" BROAD [EC:1.13.11.11]
synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.11]
xref: EC:1.13.11.11
xref: MetaCyc:TRYPTOPHAN-23-DIOXYGENASE-RXN
xref: Reactome:15133 "tryptophan 2,3-dioxygenase activity"
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0004834
name: tryptophan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O." [EC:4.2.1.20]
subset: gosubset_prok
synonym: "indoleglycerol phosphate aldolase activity" EXACT [EC:4.2.1.20]
synonym: "L-serine hydro-lyase (adding indoleglycerol-phosphate)" EXACT [EC:4.2.1.20]
synonym: "L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]" RELATED [EC:4.2.1.20]
synonym: "L-tryptophan synthetase activity" EXACT [EC:4.2.1.20]
synonym: "tryptophan desmolase activity" EXACT [EC:4.2.1.20]
synonym: "tryptophan synthetase activity" EXACT [EC:4.2.1.20]
xref: EC:4.2.1.20
xref: MetaCyc:TRYPSYN-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004835
name: tubulin-tyrosine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]
synonym: "alpha-tubulin:L-tyrosine ligase (ADP-forming)" EXACT [EC:6.3.2.25]
synonym: "TTL activity" EXACT [EC:6.3.2.25]
synonym: "tubulinyl-tyrosine ligase activity" EXACT []
xref: EC:6.3.2.25
xref: MetaCyc:6.3.2.25-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0004836
name: tyramine-beta hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of tyramine to form octopamine." [PMID:10745161]
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0004837
name: tyrosine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25]
synonym: "L-(-)-tyrosine apodecarboxylase activity" EXACT [EC:4.1.1.25]
synonym: "L-tyrosine carboxy-lyase (tyramine-forming)" EXACT [EC:4.1.1.25]
synonym: "L-tyrosine carboxy-lyase activity" EXACT [EC:4.1.1.25]
synonym: "L-tyrosine decarboxylase activity" EXACT [EC:4.1.1.25]
xref: EC:4.1.1.25
xref: MetaCyc:TYROSINE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004838
name: L-tyrosine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.5]
subset: gosubset_prok
synonym: "glutamic phenylpyruvic aminotransferase activity" RELATED [EC:2.6.1.5]
synonym: "glutamic-hydroxyphenylpyruvic transaminase activity" RELATED [EC:2.6.1.5]
synonym: "L-phenylalanine 2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.5]
synonym: "L-tyrosine aminotransferase activity" BROAD [EC:2.6.1.5]
synonym: "phenylalanine aminotransferase activity" RELATED [EC:2.6.1.5]
synonym: "phenylalanine transaminase activity" RELATED [EC:2.6.1.5]
synonym: "phenylalanine-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.5]
synonym: "phenylpyruvate transaminase activity" RELATED [EC:2.6.1.5]
synonym: "phenylpyruvic acid transaminase activity" RELATED [EC:2.6.1.5]
synonym: "TyrAT activity" RELATED [EC:2.6.1.5]
synonym: "tyrosine aminotransferase activity" BROAD []
synonym: "tyrosine transaminase activity" BROAD [EC:2.6.1.5]
synonym: "tyrosine-2-ketoglutarate aminotransferase activity" BROAD [EC:2.6.1.5]
synonym: "tyrosine-alpha-ketoglutarate aminotransferase activity" BROAD [EC:2.6.1.5]
synonym: "tyrosine-alpha-ketoglutarate transaminase activity" BROAD [EC:2.6.1.5]
xref: EC:2.6.1.5
xref: MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN
xref: Reactome:15141 "L-tyrosine:2-oxoglutarate aminotransferase activity"
is_a: GO:0070547 ! L-tyrosine aminotransferase activity

[Term]
id: GO:0004839
name: ubiquitin activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner." [http://www.bostonbiochem.com/E-301.html, PMID:10072378]
synonym: "E1" EXACT []
xref: MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN
xref: Wikipedia:Ubiquitin-activating_enzyme
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0004842
name: ubiquitin-protein ligase activity
namespace: molecular_function
alt_id: GO:0004840
alt_id: GO:0004841
def: "Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]
subset: gosubset_prok
synonym: "anaphase-promoting complex activity" NARROW [GOC:dph, GOC:tairtb]
synonym: "E2" NARROW []
synonym: "E3" NARROW []
synonym: "ubiquitin activity" RELATED [EC:6.3.2.19]
synonym: "ubiquitin conjugating enzyme activity" EXACT []
synonym: "ubiquitin ligase activity" EXACT []
synonym: "ubiquitin protein ligase activity" EXACT []
synonym: "ubiquitin protein-ligase activity" EXACT []
synonym: "ubiquitin-conjugating enzyme activity" EXACT []
synonym: "ubiquitin-ligase activity" EXACT []
synonym: "ubiquitin:protein-lysine N-ligase (AMP-forming) activity" EXACT [EC:6.3.2.19]
xref: EC:6.3.2.19
xref: MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN
xref: Reactome:202455 "ubiquitin-protein ligase activity"
is_a: GO:0019787 ! small conjugating protein ligase activity

[Term]
id: GO:0004843
name: ubiquitin-specific protease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences. Will remove ubiquitin from larger leaving groups." [ISBN:0120793709]
comment: Note that this term encompasses hydrolysis of any type of bonds formed between ubiquitin and another molecule.
subset: gosubset_prok
synonym: "ubiquitin hydrolase activity" EXACT [GOC:rl]
synonym: "UBP" NARROW []
synonym: "UCH2" NARROW []
xref: Reactome:15173 "ubiquitin-specific protease activity"
is_a: GO:0019783 ! small conjugating protein-specific protease activity

[Term]
id: GO:0004844
name: uracil DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [GOC:elh, PMID:9224623]
subset: gosubset_prok
synonym: "uracil-DNA glycosylase activity" EXACT []
xref: EC:3.2.2.-
xref: Reactome:15174 "uracil DNA N-glycosylase activity"
is_a: GO:0019104 ! DNA N-glycosylase activity

[Term]
id: GO:0004845
name: uracil phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.9]
subset: gosubset_prok
synonym: "UMP diphosphorylase activity" EXACT [EC:2.4.2.9]
synonym: "UMP pyrophosphorylase activity" EXACT [EC:2.4.2.9]
synonym: "UMP:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.9]
synonym: "UMP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.9]
synonym: "UPRTase activity" EXACT [EC:2.4.2.9]
synonym: "uridine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.9]
synonym: "uridine monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.9]
synonym: "uridylate pyrophosphorylase activity" EXACT [EC:2.4.2.9]
synonym: "uridylic pyrophosphorylase activity" EXACT [EC:2.4.2.9]
xref: EC:2.4.2.9
xref: MetaCyc:URACIL-PRIBOSYLTRANS-RXN
xref: Reactome:15175 "uracil phosphoribosyltransferase activity"
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004846
name: urate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + H2O2." [EC:1.7.3.3]
subset: gosubset_prok
synonym: "urate:oxygen oxidoreductase activity" EXACT [EC:1.7.3.3]
synonym: "uric acid oxidase activity" EXACT [EC:1.7.3.3]
synonym: "uricase activity" EXACT [EC:1.7.3.3]
synonym: "uricase II activity" NARROW [EC:1.7.3.3]
xref: EC:1.7.3.3
xref: MetaCyc:URATE-OXIDASE-RXN
xref: UM-BBD_enzymeID:e0832
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

[Term]
id: GO:0004847
name: urea carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + urea + CO2 = ADP + phosphate + urea-1-carboxylate." [EC:6.3.4.6]
subset: gosubset_prok
synonym: "ATP--urea amidolyase activity" EXACT [EC:6.3.4.6]
synonym: "UALase activity" EXACT [EC:6.3.4.6]
synonym: "UCA activity" EXACT [EC:6.3.4.6]
synonym: "urea amidolyase activity" EXACT [EC:6.3.4.6]
synonym: "urea carboxylase (hydrolysing)" EXACT [EC:6.3.4.6]
synonym: "urea carboxylase (hydrolyzing) activity" EXACT [EC:6.3.4.6]
synonym: "urea:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.3.4.6]
synonym: "urease (ATP-hydrolysing)" EXACT [EC:6.3.4.6]
synonym: "urease (ATP-hydrolyzing) activity" EXACT [EC:6.3.4.6]
xref: EC:6.3.4.6
xref: MetaCyc:UREA-CARBOXYLASE-RXN
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0004848
name: ureidoglycolate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2." [EC:3.5.3.19]
subset: gosubset_prok
synonym: "(S)-ureidoglycolate amidohydrolase (decarboxylating)" EXACT [EC:3.5.3.19]
xref: EC:3.5.3.19
xref: MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0004849
name: uridine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + uridine = ADP + UMP." [EC:2.7.1.48]
subset: gosubset_prok
synonym: "ATP:uridine 5'-phosphotransferase activity" EXACT [EC:2.7.1.48]
synonym: "pyrimidine ribonucleoside kinase activity" EXACT [EC:2.7.1.48]
synonym: "uridine kinase (phosphorylating)" EXACT [EC:2.7.1.48]
synonym: "uridine kinase reaction" EXACT []
synonym: "uridine monophosphokinase activity" EXACT [EC:2.7.1.48]
synonym: "uridine phosphokinase activity" EXACT [EC:2.7.1.48]
synonym: "uridine-cytidine kinase activity" EXACT [EC:2.7.1.48]
xref: EC:2.7.1.48
xref: MetaCyc:URIDINEKIN-RXN
is_a: GO:0019206 ! nucleoside kinase activity

[Term]
id: GO:0004850
name: uridine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate." [EC:2.4.2.3]
subset: gosubset_prok
synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.3]
synonym: "UPase activity" EXACT [EC:2.4.2.3]
synonym: "UPH" RELATED [EC:2.4.2.3]
synonym: "UrdPase activity" EXACT [EC:2.4.2.3]
synonym: "uridine:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.3]
xref: EC:2.4.2.3
xref: MetaCyc:URPHOS-RXN
xref: Reactome:15196 "uridine phosphorylase activity"
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0004851
name: uroporphyrin-III C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2." [EC:2.1.1.107]
subset: gosubset_prok
synonym: "adenosylmethionine-uroporphyrinogen III methyltransferase activity" EXACT [EC:2.1.1.107]
synonym: "CobA" RELATED [EC:2.1.1.107]
synonym: "CysG" RELATED [EC:2.1.1.107]
synonym: "S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity" EXACT [EC:2.1.1.107]
synonym: "S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase activity" EXACT [EC:2.1.1.107]
synonym: "S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase activity" EXACT [EC:2.1.1.107]
synonym: "SirA" RELATED [EC:2.1.1.107]
synonym: "SUMT activity" EXACT [EC:2.1.1.107]
synonym: "urogen III methylase activity" EXACT [EC:2.1.1.107]
synonym: "uroporphyrinogen III methylase activity" EXACT [EC:2.1.1.107]
synonym: "uroporphyrinogen methyltransferase activity" EXACT [EC:2.1.1.107]
synonym: "uroporphyrinogen-III C-methyltransferase activity" EXACT [EC:2.1.1.107]
synonym: "uroporphyrinogen-III methylase activity" EXACT [EC:2.1.1.107]
synonym: "uroporphyrinogen-III methyltransferase activity" EXACT [EC:2.1.1.107]
xref: EC:2.1.1.107
xref: MetaCyc:UROPORIIIMETHYLTRANSA-RXN
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0004852
name: uroporphyrinogen-III synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxymethylbilane = uroporphyrinogen-III + H2O." [EC:4.2.1.75]
subset: gosubset_prok
synonym: "hydroxymethylbilane hydro-lyase (cyclizing) activity" EXACT [EC:4.2.1.75]
synonym: "hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)" EXACT [EC:4.2.1.75]
synonym: "porphobilinogenase activity" EXACT [EC:4.2.1.75]
synonym: "URO-synthase activity" EXACT [EC:4.2.1.75]
synonym: "uroporphyrinogen III cosynthase activity" EXACT [EC:4.2.1.75]
synonym: "uroporphyrinogen isomerase activity" EXACT [EC:4.2.1.75]
synonym: "uroporphyrinogen-III cosynthase activity" EXACT [EC:4.2.1.75]
synonym: "uroporphyrinogen-III cosynthetase activity" EXACT [EC:4.2.1.75]
xref: EC:4.2.1.75
xref: MetaCyc:UROGENIIISYN-RXN
xref: Reactome:15200 "uroporphyrinogen-III synthase activity"
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0004853
name: uroporphyrinogen decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2." [EC:4.1.1.37]
subset: gosubset_prok
synonym: "porphyrinogen carboxy-lyase activity" EXACT [EC:4.1.1.37]
synonym: "porphyrinogen decarboxylase activity" EXACT [EC:4.1.1.37]
synonym: "uroporphyrinogen III decarboxylase activity" EXACT [EC:4.1.1.37]
synonym: "uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)" EXACT [EC:4.1.1.37]
synonym: "uroporphyrinogen-III carboxy-lyase activity" EXACT [EC:4.1.1.37]
xref: EC:4.1.1.37
xref: MetaCyc:UROGENDECARBOX-RXN
xref: Reactome:15202 "uroporphyrinogen decarboxylase activity"
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0004854
name: xanthine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+." [EC:1.17.1.4]
subset: gosubset_prok
synonym: "NAD-xanthine dehydrogenase activity" EXACT [EC:1.17.1.4]
synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.1.4]
synonym: "xanthine-NAD oxidoreductase activity" EXACT [EC:1.17.1.4]
synonym: "xanthine/NAD(+) oxidoreductase activity" EXACT [EC:1.17.1.4]
synonym: "xanthine/NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4]
synonym: "xanthine:NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4]
xref: EC:1.17.1.4
xref: MetaCyc:RXN0-901
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0004855
name: xanthine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: xanthine + H2O + O2 = urate + H2O2." [EC:1.17.3.2]
subset: gosubset_prok
synonym: "hypoxanthine-xanthine oxidase activity" BROAD [EC:1.17.3.2]
synonym: "schardinger enzyme" RELATED [EC:1.17.3.2]
synonym: "Schardinger enzyme activity" RELATED [EC:1.17.3.2]
synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.3.2]
synonym: "xanthine:O(2) oxidoreductase activity" EXACT [EC:1.17.3.2]
synonym: "xanthine:O2 oxidoreductase activity" EXACT [EC:1.17.3.2]
synonym: "xanthine:oxygen oxidoreductase activity" EXACT [EC:1.17.3.2]
synonym: "xanthine:xanthine oxidase activity" EXACT [EC:1.17.3.2]
xref: EC:1.17.3.2
xref: MetaCyc:XANTHINE-OXIDASE-RXN
xref: Reactome:15204 "xanthine oxidase activity"
xref: UM-BBD_enzymeID:e0781
is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor

[Term]
id: GO:0004856
name: xylulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-xylulose = ADP + D-xylulose 5-phosphate." [EC:2.7.1.17]
subset: gosubset_prok
synonym: "ATP:D-xylulose 5-phosphotransferase activity" EXACT [EC:2.7.1.17]
synonym: "D-xylulokinase activity" EXACT [EC:2.7.1.17]
synonym: "xylulokinase (phosphorylating)" EXACT [EC:2.7.1.17]
synonym: "xylulose kinase activity" EXACT [EC:2.7.1.17]
xref: EC:2.7.1.17
xref: MetaCyc:XYLULOKIN-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0004857
name: enzyme inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of an enzyme." [GOC:ai]
subset: gosubset_prok
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0004858
name: dUTP pyrophosphatase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of dUTP pyrophosphatase." [GOC:mah]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0004859
name: phospholipase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid." [GOC:ai, GOC:rl]
is_a: GO:0055102 ! lipase inhibitor activity

[Term]
id: GO:0004860
name: protein kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0019210 ! kinase inhibitor activity
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0004861
name: cyclin-dependent protein kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a cyclin-dependent protein kinase." [GOC:mah]
synonym: "CDK inhibitor" RELATED []
synonym: "cyclin dependent kinase inhibitor" RELATED []
synonym: "cyclin dependent protein kinase inhibitor activity" EXACT []
synonym: "cyclin-dependent kinase inhibitor" RELATED []
xref: Reactome:15226 "cyclin-dependent protein kinase inhibitor activity"
is_a: GO:0016538 ! cyclin-dependent protein kinase regulator activity
is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity

[Term]
id: GO:0004862
name: cAMP-dependent protein kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a cAMP-dependent protein kinase." [GOC:mah]
xref: Reactome:15228 "cAMP-dependent protein kinase inhibitor activity"
is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity

[Term]
id: GO:0004864
name: phosphoprotein phosphatase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins." [GOC:ai]
synonym: "protein phosphatase inhibitor activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0019212 ! phosphatase inhibitor activity

[Term]
id: GO:0004865
name: protein serine/threonine phosphatase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H20 = protein serine/threonine + phosphate." [GOC:dph, GOC:tb]
is_a: GO:0004864 ! phosphoprotein phosphatase inhibitor activity

[Term]
id: GO:0004866
name: endopeptidase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl]
subset: gosubset_prok
synonym: "alpha-2 macroglobulin" RELATED []
synonym: "endoproteinase inhibitor" EXACT []
synonym: "proteinase inhibitor" BROAD []
is_a: GO:0030414 ! peptidase inhibitor activity

[Term]
id: GO:0004867
name: serine-type endopeptidase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
subset: gosubset_prok
synonym: "serine protease inhibitor activity" EXACT []
synonym: "serine proteinase inhibitor activity" EXACT []
synonym: "serpin activity" NARROW []
xref: Reactome:15233 "serine-type endopeptidase inhibitor activity"
is_a: GO:0004866 ! endopeptidase inhibitor activity

[Term]
id: GO:0004868
name: serpin
namespace: molecular_function
def: "OBSOLETE. A superfamily of proteins, many of which inhibit serine proteinases and exhibit a high degree of homology with classical serine proteinase inhibitors such as alpha1-antitrypsin or antithrombin." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
consider: GO:0004867

[Term]
id: GO:0004869
name: cysteine-type endopeptidase inhibitor activity
namespace: molecular_function
alt_id: GO:0004870
def: "Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "cysteine protease inhibitor activity" EXACT [GOC:dph, GOC:tb]
synonym: "thiol protease inhibitor" EXACT []
is_a: GO:0004866 ! endopeptidase inhibitor activity

[Term]
id: GO:0004871
name: signal transducer activity
namespace: molecular_function
def: "Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Ligands do NOT have the molecular function 'signal transducer activity'.
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0060089 ! molecular transducer activity

[Term]
id: GO:0004872
name: receptor activity
namespace: molecular_function
def: "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: gosubset_prok
synonym: "receptor guanylate cyclase activity" NARROW []
is_a: GO:0004871 ! signal transducer activity

[Term]
id: GO:0004873
name: asialoglycoprotein receptor activity
namespace: molecular_function
def: "The mediation of the endocytosis of plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate moieties has been removed; recognizes the terminal galactose and N-acetylgalactosamine units; the complex of receptor and ligand is internalized and transported to a sorting organelle where disassociation occurs, the receptor being recycled to the cell membrane." [PMID:11278827]
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0004874
name: aryl hydrocarbon receptor activity
namespace: molecular_function
def: "Combining with an aryl hydrocarbon to initiate a change in cell activity." [GOC:ai]
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0004875
name: complement receptor activity
namespace: molecular_function
def: "Combining with any component or product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways.
is_a: GO:0001848 ! complement binding
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0004876
name: complement component C3a receptor activity
namespace: molecular_function
def: "Combining with the C3a product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0004877
name: complement component C3b receptor activity
namespace: molecular_function
def: "Combining with the C3b product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0001850 ! complement component C3a binding
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0004878
name: complement component C5a receptor activity
namespace: molecular_function
def: "Combining with the C5a product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0001856 ! complement component C5a binding
is_a: GO:0004875 ! complement receptor activity

[Term]
id: GO:0004879
name: ligand-dependent nuclear receptor activity
namespace: molecular_function
def: "A ligand-dependent receptor found in the nucleus of the cell." [GOC:ai]
comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'.
synonym: "nuclear hormone receptor" NARROW []
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0004880
name: juvenile hormone receptor activity
namespace: molecular_function
def: "Combining with juvenile hormone to initiate a change in cell activity." [GOC:ai]
comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'.
is_a: GO:0004879 ! ligand-dependent nuclear receptor activity

[Term]
id: GO:0004882
name: androgen receptor activity
namespace: molecular_function
def: "Combining with an androgen to initiate a change in cell activity." [GOC:ai]
comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'.
is_a: GO:0003707 ! steroid hormone receptor activity

[Term]
id: GO:0004883
name: glucocorticoid receptor activity
namespace: molecular_function
def: "Combining with a glucocorticoid to initiate a change in cell activity." [GOC:ai]
comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'.
is_a: GO:0003707 ! steroid hormone receptor activity

[Term]
id: GO:0004884
name: ecdysteroid hormone receptor activity
namespace: molecular_function
def: "Combining with ecdysteroid hormone to initiate a change in cell activity." [GOC:ai]
comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'.
is_a: GO:0003707 ! steroid hormone receptor activity

[Term]
id: GO:0004886
name: retinoid-X receptor activity
namespace: molecular_function
def: "Combining with 9-cis retinoic acid to initiate a change in cell activity." [PMID:17132853]
synonym: "RXR" EXACT []
is_a: GO:0003708 ! retinoic acid receptor activity

[Term]
id: GO:0004887
name: thyroid hormone receptor activity
namespace: molecular_function
def: "Combining with thyroid hormone to initiate a change in cell activity." [GOC:ai]
comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'.
is_a: GO:0004879 ! ligand-dependent nuclear receptor activity

[Term]
id: GO:0004888
name: transmembrane receptor activity
namespace: molecular_function
def: "Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle." [GOC:go_curators, Wikipedia:Transmembrane_receptor]
subset: gosubset_prok
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0004889
name: nicotinic acetylcholine-activated cation-selective channel activity
namespace: molecular_function
alt_id: GO:0016904
is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity
is_a: GO:0005261 ! cation channel activity

[Term]
id: GO:0004890
name: GABA-A receptor activity
namespace: molecular_function
def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'chloride channel activity ; GO:0005254' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'.
is_a: GO:0016917 ! GABA receptor activity

[Term]
id: GO:0004892
name: B cell receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes the receptor type, and not an activity.
is_obsolete: true
consider: GO:0003823

[Term]
id: GO:0004894
name: T cell receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes a receptor type, and not an activity.
is_obsolete: true
consider: GO:0032394
consider: GO:0032395
consider: GO:0042605

[Term]
id: GO:0004895
name: cell adhesion receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with cell adhesion molecules to initiate a change in cell activity." [GOC:ai]
comment: This term was made obsolete because it represents gene products involved in the biological process of cell adhesion.
is_obsolete: true
consider: GO:0005102
consider: GO:0005515
consider: GO:0007155
consider: GO:0016021
consider: GO:0030246
consider: GO:0050839

[Term]
id: GO:0004896
name: cytokine receptor activity
namespace: molecular_function
alt_id: GO:0004907
def: "Combining with a cytokine to initiate a change in cell activity." [GOC:add, GOC:mah]
synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor activity" RELATED []
synonym: "IL receptor" NARROW []
synonym: "interleukin receptor activity" NARROW []
is_a: GO:0004888 ! transmembrane receptor activity
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0004897
name: ciliary neurotrophic factor receptor activity
namespace: molecular_function
def: "Combining with ciliary neurotrophic factor to initiate a change in cell activity." [GOC:mah]
synonym: "CNTF receptor activity" EXACT [GOC:mah]
synonym: "gp130" NARROW []
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004898
name: gp130
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0004897
consider: GO:0004915
consider: GO:0004921
consider: GO:0005062

[Term]
id: GO:0004900
name: erythropoietin receptor activity
namespace: molecular_function
def: "Combining with erythropoietin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004901
name: granulocyte macrophage colony-stimulating factor receptor activity
namespace: molecular_function
alt_id: GO:0030525
def: "Combining with granulocyte macrophage colony-stimulating factor to initiate a change in cell activity." [GOC:mah]
synonym: "CSF-2" RELATED []
synonym: "GM-CSF receptor activity" EXACT []
synonym: "GMC-SF receptor activity" EXACT []
is_a: GO:0004900 ! erythropoietin receptor activity

[Term]
id: GO:0004902
name: granulocyte colony-stimulating factor receptor activity
namespace: molecular_function
alt_id: GO:0030524
def: "Combining with granulocyte colony-stimulating factor to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004903
name: growth hormone receptor activity
namespace: molecular_function
def: "Combining with growth hormone to initiate a change in cell activity." [GOC:ai]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004904
name: interferon receptor activity
namespace: molecular_function
def: "Combining with an interferon to initiate a change in cell activity." [GOC:ai]
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0019961 ! interferon binding

[Term]
id: GO:0004905
name: type I interferon receptor activity
namespace: molecular_function
def: "Combining with a type I interferon to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]
synonym: "interferon-alpha receptor activity" NARROW []
synonym: "interferon-alpha/beta receptor activity" NARROW []
synonym: "interferon-beta receptor activity" NARROW []
synonym: "interferon-delta receptor activity" NARROW []
synonym: "interferon-epsilon receptor activity" NARROW []
synonym: "interferon-kappa receptor activity" NARROW []
synonym: "interferon-omega receptor activity" NARROW []
synonym: "interferon-tau receptor activity" NARROW []
synonym: "interferon-zeta receptor activity" NARROW []
is_a: GO:0004904 ! interferon receptor activity
is_a: GO:0019962 ! type I interferon binding

[Term]
id: GO:0004906
name: interferon-gamma receptor activity
namespace: molecular_function
def: "Combining with interferon-gamma to initiate a change in cell activity. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383]
synonym: "type II interferon receptor activity" EXACT []
is_a: GO:0004904 ! interferon receptor activity
is_a: GO:0019964 ! interferon-gamma binding

[Term]
id: GO:0004908
name: interleukin-1 receptor activity
namespace: molecular_function
def: "Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response." [GOC:jl]
synonym: "IL-1 receptor activity" EXACT []
synonym: "IL-1R" EXACT []
xref: Wikipedia:Interleukin-1_receptor
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0019966 ! interleukin-1 binding

[Term]
id: GO:0004909
name: interleukin-1, Type I, activating receptor activity
namespace: molecular_function
alt_id: GO:0019967
def: "Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins." [PMID:15062641, PMID:18613828]
synonym: "IL-1 type I, activating binding" EXACT []
synonym: "IL-1 type I, activating receptor" EXACT []
synonym: "interleukin-1 activating receptor activity" EXACT [GOC:mah]
synonym: "interleukin-1 Type I receptor activity" EXACT [GOC:mah]
synonym: "interleukin-1, Type I, activating binding" RELATED []
is_a: GO:0004908 ! interleukin-1 receptor activity

[Term]
id: GO:0004910
name: interleukin-1, Type II, blocking receptor activity
namespace: molecular_function
alt_id: GO:0019968
def: "Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors." [PMID:15062641, PMID:18613828]
synonym: "IL-1 type II, blocking binding" EXACT []
synonym: "IL-1 type II, blocking receptor" EXACT []
synonym: "interleukin-1 blocking receptor activity" EXACT [GOC:mah]
synonym: "interleukin-1 Type II receptor activity" EXACT [GOC:mah]
synonym: "interleukin-1, Type II, blocking binding" RELATED []
is_a: GO:0004908 ! interleukin-1 receptor activity

[Term]
id: GO:0004911
name: interleukin-2 receptor activity
namespace: molecular_function
def: "Combining with interleukin-2 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-2 receptor activity" EXACT [GOC:mah]
synonym: "IL-2R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0019976 ! interleukin-2 binding

[Term]
id: GO:0004912
name: interleukin-3 receptor activity
namespace: molecular_function
def: "Combining with interleukin-3 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-3 receptor activity" EXACT [GOC:mah]
synonym: "IL-3R" EXACT []
xref: Wikipedia:Interleukin-3_receptor
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0019978 ! interleukin-3 binding

[Term]
id: GO:0004913
name: interleukin-4 receptor activity
namespace: molecular_function
def: "Combining with interleukin-4 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-4 receptor activity" EXACT [GOC:mah]
synonym: "IL-4R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0019979 ! interleukin-4 binding

[Term]
id: GO:0004914
name: interleukin-5 receptor activity
namespace: molecular_function
def: "Combining with interleukin-5 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-5 receptor activity" EXACT [GOC:mah]
synonym: "IL-5R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0019980 ! interleukin-5 binding

[Term]
id: GO:0004915
name: interleukin-6 receptor activity
namespace: molecular_function
def: "Combining with interleukin-6 to initiate a change in cell activity." [GOC:jl]
synonym: "gp130" NARROW []
synonym: "IL-6 receptor activity" EXACT [GOC:mah]
synonym: "IL-6R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0019981 ! interleukin-6 binding

[Term]
id: GO:0004917
name: interleukin-7 receptor activity
namespace: molecular_function
def: "Combining with interleukin-7 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-7 receptor activity" EXACT [GOC:mah]
synonym: "IL-7R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0019982 ! interleukin-7 binding

[Term]
id: GO:0004918
name: interleukin-8 receptor activity
namespace: molecular_function
def: "Combining with interleukin-8 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-8 receptor activity" EXACT [GOC:mah]
synonym: "IL-8R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0016494 ! C-X-C chemokine receptor activity
is_a: GO:0019959 ! interleukin-8 binding

[Term]
id: GO:0004919
name: interleukin-9 receptor activity
namespace: molecular_function
def: "Combining with interleukin-9 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-9 receptor activity" EXACT [GOC:mah]
synonym: "IL-9R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0019983 ! interleukin-9 binding

[Term]
id: GO:0004920
name: interleukin-10 receptor activity
namespace: molecular_function
def: "Combining with interleukin-10 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-10 receptor activity" EXACT [GOC:mah]
synonym: "IL-10R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0019969 ! interleukin-10 binding

[Term]
id: GO:0004921
name: interleukin-11 receptor activity
namespace: molecular_function
def: "Combining with interleukin-11 to initiate a change in cell activity." [GOC:jl]
synonym: "gp130" NARROW []
synonym: "IL-11 receptor activity" EXACT [GOC:mah]
synonym: "IL-11R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0019970 ! interleukin-11 binding

[Term]
id: GO:0004923
name: leukemia inhibitory factor receptor activity
namespace: molecular_function
alt_id: GO:0004899
def: "Combining with leukemia inhibitory factor to initiate a change in cell activity." [GOC:mah]
synonym: "leukemia inhibitory factor receptor beta-protein activity" NARROW [GOC:mah]
synonym: "LIF receptor activity" EXACT [GOC:mah]
is_a: GO:0004897 ! ciliary neurotrophic factor receptor activity
is_a: GO:0005062 ! hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity

[Term]
id: GO:0004924
name: oncostatin-M receptor activity
namespace: molecular_function
def: "Combining with oncostatin-M to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004925
name: prolactin receptor activity
namespace: molecular_function
def: "Combining with prolactin to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0004926
name: non-G-protein coupled 7TM receptor activity
namespace: molecular_function
subset: gosubset_prok
synonym: "non G protein coupled 7TM receptor activity" EXACT []
synonym: "non-G-protein-coupled 7TM receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0004927
name: sevenless receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a gene product rather than an activity.
is_obsolete: true
consider: GO:0004714
consider: GO:0004926
consider: GO:0008288

[Term]
id: GO:0004928
name: frizzled receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators]
comment: This term was made obsolete because it represents a gene product rather than an activity.
is_obsolete: true
replaced_by: GO:0042813
consider: GO:0016055

[Term]
id: GO:0004929
name: frizzled-2 receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with to a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators]
comment: This term was made obsolete because it represents a gene product rather than an activity.
is_obsolete: true
replaced_by: GO:0042813
consider: GO:0007223

[Term]
id: GO:0004930
name: G-protein coupled receptor activity
namespace: molecular_function
alt_id: GO:0016526
def: "A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers." [GOC:dph, GOC:tb, http://www.iuphar-db.org]
subset: gosubset_prok
synonym: "G protein coupled receptor activity" EXACT []
synonym: "G protein linked receptor activity" EXACT []
synonym: "G-protein coupled receptor activity, unknown ligand" EXACT []
synonym: "G-protein linked receptor activity" EXACT []
synonym: "G-protein-coupled receptor activity" EXACT []
synonym: "GPCR activity" EXACT []
synonym: "ligand-dependent GPCR activity" EXACT []
synonym: "orphan G protein coupled receptor activity" EXACT []
synonym: "orphan G-protein coupled receptor activity" EXACT []
synonym: "orphan GPCR activity" EXACT []
xref: Reactome:35 "G-protein coupled receptor activity"
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0004931
name: ATP-gated cation channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular ATP has been bound by the channel complex or one of its constituent parts." [GOC:mah, PMID:9755289]
comment: Note that this term refers to an activity and not a gene product. Consider also annotating to the molecular function term 'purinergic nucleotide receptor activity ; GO:0001614'.
synonym: "P2X activity" RELATED []
synonym: "purinoceptor" BROAD []
synonym: "purinoreceptor" BROAD []
is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity
is_a: GO:0005261 ! cation channel activity

[Term]
id: GO:0004932
name: mating-type factor pheromone receptor activity
namespace: molecular_function
def: "Combining with a mating-type factor pheromone to initiate a change in cell activity." [GOC:dph]
subset: gosubset_prok
is_a: GO:0016503 ! pheromone receptor activity

[Term]
id: GO:0004933
name: mating-type a-factor pheromone receptor activity
namespace: molecular_function
def: "Combining with the mating-type a-factor pheromone to initiate a change in cell activity." [GOC:mah]
synonym: "class D G protein coupled receptor activity" BROAD []
synonym: "class D G-protein coupled receptor activity" BROAD []
synonym: "class D G-protein-coupled receptor activity" BROAD []
synonym: "class D GPCR activity" BROAD []
is_a: GO:0004932 ! mating-type factor pheromone receptor activity

[Term]
id: GO:0004934
name: mating-type alpha-factor pheromone receptor activity
namespace: molecular_function
def: "Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity." [GOC:mah]
synonym: "class D G protein coupled receptor activity" BROAD []
synonym: "class D G-protein coupled receptor activity" BROAD []
synonym: "class D G-protein-coupled receptor activity" BROAD []
synonym: "class D GPCR activity" BROAD []
is_a: GO:0004932 ! mating-type factor pheromone receptor activity

[Term]
id: GO:0004935
name: adrenoceptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity." [GOC:mah, IUPHAR_GPCR:1274]
synonym: "adrenergic receptor" EXACT []
xref: Wikipedia:Adrenergic_receptor
is_a: GO:0008227 ! G-protein coupled amine receptor activity

[Term]
id: GO:0004936
name: alpha-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274]
synonym: "alpha adrenoceptor" EXACT []
is_a: GO:0004935 ! adrenoceptor activity

[Term]
id: GO:0004937
name: alpha1-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]
synonym: "alpha1 adrenoceptor" EXACT []
is_a: GO:0004936 ! alpha-adrenergic receptor activity

[Term]
id: GO:0004938
name: alpha2-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]
synonym: "alpha2 adrenoceptor" EXACT []
is_a: GO:0004936 ! alpha-adrenergic receptor activity

[Term]
id: GO:0004939
name: beta-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]
synonym: "beta adrenoceptor" EXACT []
is_a: GO:0004935 ! adrenoceptor activity

[Term]
id: GO:0004940
name: beta1-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274]
synonym: "beta1 adrenoceptor" EXACT []
is_a: GO:0004939 ! beta-adrenergic receptor activity

[Term]
id: GO:0004941
name: beta2-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274]
synonym: "beta2 adrenoceptor" EXACT []
is_a: GO:0004939 ! beta-adrenergic receptor activity

[Term]
id: GO:0004942
name: anaphylatoxin receptor activity
namespace: molecular_function
def: "Combining with anaphylatoxin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0004943
name: C3a anaphylatoxin receptor activity
namespace: molecular_function
def: "Combining with anaphylatoxin C3a to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004942 ! anaphylatoxin receptor activity

[Term]
id: GO:0004944
name: C5a anaphylatoxin receptor activity
namespace: molecular_function
def: "Combining with anaphylatoxin C5a to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004942 ! anaphylatoxin receptor activity

[Term]
id: GO:0004945
name: angiotensin type II receptor activity
namespace: molecular_function
is_a: GO:0001595 ! angiotensin receptor activity

[Term]
id: GO:0004946
name: bombesin receptor activity
namespace: molecular_function
def: "Combining with bombesin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0004947
name: bradykinin receptor activity
namespace: molecular_function
def: "Combining with bradykinin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0004948
name: calcitonin receptor activity
namespace: molecular_function
def: "Combining with calcitonin to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0004949
name: cannabinoid receptor activity
namespace: molecular_function
def: "Combining with cannabinoids to initiate a change in cell activity." [GOC:dph, IUPHAR_GPCR:1279]
synonym: "cannaboid receptor" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0004950
name: chemokine receptor activity
namespace: molecular_function
def: "Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity." [IUPHAR_GPCR:1280, PMID:8662823]
is_a: GO:0001637 ! G-protein chemoattractant receptor activity
is_a: GO:0019956 ! chemokine binding

[Term]
id: GO:0004951
name: cholecystokinin receptor activity
namespace: molecular_function
def: "Combining with a cholecystokinin, any of a group of related neuropeptides secreted by the upper intestinal mucosa and also found in the central nervous system, to initiate a change in cell activity." [GOC:ai, GOC:mah, http://cancerweb.ncl.ac.uk/]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0004952
name: dopamine receptor activity
namespace: molecular_function
def: "Combining with the neurotransmitter dopamine to initiate a change in cell activity." [IUPHAR_GPCR:1282]
is_a: GO:0008227 ! G-protein coupled amine receptor activity
is_a: GO:0035240 ! dopamine binding

[Term]
id: GO:0004953
name: icosanoid receptor activity
namespace: molecular_function
def: "Combining with an icosanoid to initiate a change in cell activity." [GOC:dph]
synonym: "eicosanoid receptor activity" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0004954
name: prostanoid receptor activity
namespace: molecular_function
def: "Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0004953 ! icosanoid receptor activity

[Term]
id: GO:0004955
name: prostaglandin receptor activity
namespace: molecular_function
def: "Combining with a prostaglandin (PG) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0004954 ! prostanoid receptor activity

[Term]
id: GO:0004956
name: prostaglandin D receptor activity
namespace: molecular_function
def: "Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "PGD receptor activity" RELATED []
synonym: "PGD(2) receptor activity" EXACT []
is_a: GO:0004955 ! prostaglandin receptor activity

[Term]
id: GO:0004957
name: prostaglandin E receptor activity
namespace: molecular_function
def: "Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "PGE receptor activity" RELATED []
synonym: "PGE(2) receptor activity" EXACT []
is_a: GO:0004955 ! prostaglandin receptor activity

[Term]
id: GO:0004958
name: prostaglandin F receptor activity
namespace: molecular_function
def: "Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "PGF receptor activity" RELATED []
synonym: "PGF(2-alpha) receptor activity" EXACT []
is_a: GO:0004955 ! prostaglandin receptor activity

[Term]
id: GO:0004960
name: thromboxane receptor activity
namespace: molecular_function
def: "Combining with a thromboxane (TXA) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "TXA receptor activity" EXACT []
is_a: GO:0004954 ! prostanoid receptor activity

[Term]
id: GO:0004961
name: thromboxane A2 receptor activity
namespace: molecular_function
def: "Combining with thromboxane A2 (TXA(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "TXA(2) receptor activity" EXACT []
is_a: GO:0004960 ! thromboxane receptor activity

[Term]
id: GO:0004962
name: endothelin receptor activity
namespace: molecular_function
def: "Combining with endothelin to initiate a change in cell activity." [GOC:dph, IUPHAR_GPCR:1283]
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0004963
name: follicle-stimulating hormone receptor activity
namespace: molecular_function
def: "Combining with follicle-stimulating hormone to initiate a change in cell activity." [GOC:mah]
synonym: "follicle stimulating hormone receptor activity" EXACT []
is_a: GO:0016500 ! protein-hormone receptor activity

[Term]
id: GO:0004964
name: lutropin-choriogonadotropic hormone receptor activity
namespace: molecular_function
alt_id: GO:0004976
def: "Combining with lutropin-choriogonadotropic hormone to initiate a change in cell activity." [GOC:mah]
is_a: GO:0016500 ! protein-hormone receptor activity

[Term]
id: GO:0004965
name: GABA-B receptor activity
namespace: molecular_function
def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors." [GOC:ai, IUPHAR_RECEPTOR:1276]
is_a: GO:0008066 ! glutamate receptor activity
is_a: GO:0016917 ! GABA receptor activity

[Term]
id: GO:0004966
name: galanin receptor activity
namespace: molecular_function
def: "Combining with galanin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0004967
name: glucagon receptor activity
namespace: molecular_function
def: "Combining with glucagon to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0004968
name: gonadotropin-releasing hormone receptor activity
namespace: molecular_function
def: "Combining with gonadotropin-releasing hormone to initiate a change in cell activity." [GOC:mah]
is_a: GO:0016500 ! protein-hormone receptor activity

[Term]
id: GO:0004969
name: histamine receptor activity
namespace: molecular_function
def: "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai]
is_a: GO:0008227 ! G-protein coupled amine receptor activity

[Term]
id: GO:0004970
name: ionotropic glutamate receptor activity
namespace: molecular_function
def: "Combining with glutamate to initiate a change in cell activity through the regulation of ion channels." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'glutamate-gated ion channel activity ; GO:0005234' and 'cation channel activity ; GO:0005261'.
subset: gosubset_prok
is_a: GO:0008066 ! glutamate receptor activity

[Term]
id: GO:0004971
name: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
namespace: molecular_function
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'.
is_a: GO:0004970 ! ionotropic glutamate receptor activity

[Term]
id: GO:0004972
name: N-methyl-D-aspartate selective glutamate receptor activity
namespace: molecular_function
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'.
synonym: "NMDA receptor" EXACT []
xref: Wikipedia:NMDA_receptor
is_a: GO:0004970 ! ionotropic glutamate receptor activity

[Term]
id: GO:0004973
name: N-methyl-D-aspartate receptor-associated protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
is_obsolete: true
consider: GO:0005102
consider: GO:0005515

[Term]
id: GO:0004974
name: leukotriene receptor activity
namespace: molecular_function
def: "Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0004977
name: melanocortin receptor activity
namespace: molecular_function
def: "Combining with melanocortin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0004978
name: adrenocorticotropin receptor activity
namespace: molecular_function
def: "Combining with adrenocorticotropin to initiate a change in cell activity." [GOC:ai]
synonym: "ACTH receptor activity" EXACT []
synonym: "adrenocorticotropic hormone receptor activity" EXACT []
is_a: GO:0004977 ! melanocortin receptor activity
is_a: GO:0008188 ! neuropeptide receptor activity
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0004979
name: beta-endorphin receptor activity
namespace: molecular_function
def: "Combining with beta-endorphin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0004977 ! melanocortin receptor activity
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0004980
name: melanocyte stimulating hormone receptor activity
namespace: molecular_function
def: "Combining with melanocyte stimulating hormone to initiate a change in cell activity." [GOC:jl, PMID:7581459]
synonym: "melanophore stimulating hormone receptor activity" EXACT []
synonym: "MSH receptor activity" BROAD []
synonym: "MSHR activity" BROAD []
is_a: GO:0004977 ! melanocortin receptor activity
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0004981
name: muscarinic acetylcholine receptor activity
namespace: molecular_function
def: "Combining with acetylcholine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of muscarinic receptors." [GOC:mah, IUPHAR_GPCR:1271]
is_a: GO:0016907 ! G-protein coupled acetylcholine receptor activity

[Term]
id: GO:0004982
name: N-formyl peptide receptor activity
namespace: molecular_function
def: "Combining with an N-formyl peptide to initiate a change in cell activity." [GOC:ai]
synonym: "Fmet-leu-phe receptor" EXACT []
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0004983
name: neuropeptide Y receptor activity
namespace: molecular_function
def: "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0004984
name: olfactory receptor activity
namespace: molecular_function
def: "Combining with airborne compounds to initiate a change in cell activity. These receptors are used for the sense of smell." [GOC:dph]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0004985
name: opioid receptor activity
namespace: molecular_function
def: "Combining with an opioid, any narcotic derived from or resembling opium, to initiate a change in cell activity." [GOC:ai, http://cancerweb.ncl.ac.uk/]
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0004986
name: delta-opioid receptor activity
namespace: molecular_function
is_a: GO:0004985 ! opioid receptor activity

[Term]
id: GO:0004987
name: kappa-opioid receptor activity
namespace: molecular_function
is_a: GO:0004985 ! opioid receptor activity

[Term]
id: GO:0004988
name: mu-opioid receptor activity
namespace: molecular_function
is_a: GO:0004985 ! opioid receptor activity

[Term]
id: GO:0004989
name: octopamine receptor activity
namespace: molecular_function
def: "Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [GOC:ai, http://cancerweb.ncl.ac.uk/]
is_a: GO:0008227 ! G-protein coupled amine receptor activity

[Term]
id: GO:0004990
name: oxytocin receptor activity
namespace: molecular_function
def: "Combining with oxytocin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0004991
name: parathyroid hormone receptor activity
namespace: molecular_function
def: "Combining with parathyroid hormone to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0004992
name: platelet activating factor receptor activity
namespace: molecular_function
def: "Combining with platelet activating factor to initiate a change in cell activity." [GOC:mah]
synonym: "PAF receptor activity" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0004993
name: serotonin receptor activity
namespace: molecular_function
alt_id: GO:0001585
def: "Combining with the biogenic amine serotonin, a neurotransmitter and hormone found in vertebrates, invertebrates and plants, to initiate a change in cell activity." [GOC:ai, http://cancerweb.ncl.ac.uk/]
synonym: "5-HT receptor" EXACT []
synonym: "5-hydroxytryptamine receptor" EXACT []
xref: Wikipedia:5-HT_receptor
is_a: GO:0008227 ! G-protein coupled amine receptor activity

[Term]
id: GO:0004994
name: somatostatin receptor activity
namespace: molecular_function
def: "Combining with somatostatin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0004995
name: tachykinin receptor activity
namespace: molecular_function
def: "Combining with tachykinin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0004996
name: thyroid-stimulating hormone receptor activity
namespace: molecular_function
def: "Combining with thyroid-stimulating hormone to initiate a change in cell activity." [GOC:mah]
synonym: "thyrotropin receptor" EXACT []
xref: Wikipedia:Thyrotropin_receptor
is_a: GO:0016500 ! protein-hormone receptor activity

[Term]
id: GO:0004997
name: thyrotropin-releasing hormone receptor activity
namespace: molecular_function
def: "Combining with thyrotropin-releasing hormone to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0004998
name: transferrin receptor activity
namespace: molecular_function
def: "Combining with transferrin to initiate a change in cell activity." [GOC:mah]
subset: gosubset_prok
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0004999
name: vasoactive intestinal polypeptide receptor activity
namespace: molecular_function
def: "Combining with vasoactive intestinal polypeptide to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0005000
name: vasopressin receptor activity
namespace: molecular_function
def: "Combining with vasopressin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0005001
name: transmembrane receptor protein tyrosine phosphatase activity
namespace: molecular_function
is_a: GO:0004725 ! protein tyrosine phosphatase activity
is_a: GO:0019198 ! transmembrane receptor protein phosphatase activity

[Term]
id: GO:0005003
name: ephrin receptor activity
namespace: molecular_function
def: "Combining with an ephrin to initiate a change in cell activity." [GOC:mah]
synonym: "Eph receptor activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005004
name: GPI-linked ephrin receptor activity
namespace: molecular_function
synonym: "GPI-linked Eph receptor activity" EXACT []
is_a: GO:0005003 ! ephrin receptor activity

[Term]
id: GO:0005005
name: transmembrane-ephrin receptor activity
namespace: molecular_function
synonym: "transmembrane-Eph receptor activity" EXACT []
is_a: GO:0005003 ! ephrin receptor activity

[Term]
id: GO:0005006
name: epidermal growth factor receptor activity
namespace: molecular_function
alt_id: GO:0005023
def: "Combining with an epidermal growth factor to initiate a change in cell activity." [GOC:bf]
subset: gosubset_prok
synonym: "EGF receptor activity" EXACT []
synonym: "EGFR" EXACT []
synonym: "TGF-alpha receptor activity" EXACT []
synonym: "transforming growth factor-alpha receptor activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005007
name: fibroblast growth factor receptor activity
namespace: molecular_function
def: "Combining with fibroblast growth factor to initiate a change in cell activity." [GOC:mah]
synonym: "FGF receptor activity" EXACT []
synonym: "FGFR" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005008
name: hepatocyte growth factor receptor activity
namespace: molecular_function
def: "Combining with hepatocye growth factor to initiate a change in cell activity." [GOC:mah]
synonym: "HGF receptor activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005009
name: insulin receptor activity
namespace: molecular_function
def: "Combining with insulin to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005010
name: insulin-like growth factor receptor activity
namespace: molecular_function
def: "Combining with an insulin-like growth factor to initiate a change in cell activity." [GOC:mah]
synonym: "IGF receptor activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005011
name: macrophage colony stimulating factor receptor activity
namespace: molecular_function
def: "Combining with macrophage colony stimulating factor to initiate a change in cell activity." [GOC:mah]
synonym: "CSF-1" NARROW []
synonym: "Fms" NARROW []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005012
name: Neu/ErbB-2 receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a class of receptor rather than an activity.
is_obsolete: true
consider: GO:0043125

[Term]
id: GO:0005013
name: neurotrophin TRK receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jic]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0004714
consider: GO:0007165
consider: GO:0019838
consider: GO:0043121

[Term]
id: GO:0005014
name: neurotrophin TRKA receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jic]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0004714
consider: GO:0007165
consider: GO:0048404
consider: GO:0048406

[Term]
id: GO:0005015
name: neurotrophin TRKB receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jic]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0004714
consider: GO:0007165
consider: GO:0048403
consider: GO:0048404
consider: GO:0048405

[Term]
id: GO:0005016
name: neurotrophin TRKC receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jic]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0004714
consider: GO:0007165
consider: GO:0048404

[Term]
id: GO:0005017
name: platelet-derived growth factor receptor activity
namespace: molecular_function
def: "Combining with platelet-derived growth factor to initiate a change in cell activity." [GOC:mah]
synonym: "PDGF receptor activity" EXACT []
synonym: "PDGFR activity" EXACT []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005018
name: platelet-derived growth factor alpha-receptor activity
namespace: molecular_function
synonym: "PDGF alpha-receptor activity" EXACT []
is_a: GO:0005017 ! platelet-derived growth factor receptor activity

[Term]
id: GO:0005019
name: platelet-derived growth factor beta-receptor activity
namespace: molecular_function
synonym: "PDGF beta-receptor activity" EXACT []
is_a: GO:0005017 ! platelet-derived growth factor receptor activity

[Term]
id: GO:0005020
name: stem cell factor receptor activity
namespace: molecular_function
def: "Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity." [GOC:jl, PMID:10698217]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005021
name: vascular endothelial growth factor receptor activity
namespace: molecular_function
def: "Combining with vascular endothelial growth factor to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0005024
name: transforming growth factor beta receptor activity
namespace: molecular_function
def: "Combining with transforming growth factor beta to initiate a change in cell activity." [GOC:mah]
synonym: "TGF-beta receptor activity" EXACT []
synonym: "TGFbeta receptor activity" EXACT []
synonym: "TGFbetaR" EXACT []
is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity

[Term]
id: GO:0005025
name: transforming growth factor beta receptor activity, type I
namespace: molecular_function
def: "Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity." [GOC:mah, Reactome:REACT_6945.1]
synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED []
synonym: "type I TGF-beta receptor activity" EXACT []
synonym: "type I TGFbeta receptor activity" EXACT []
synonym: "type I transforming growth factor beta receptor activity" EXACT []
is_a: GO:0005024 ! transforming growth factor beta receptor activity

[Term]
id: GO:0005026
name: transforming growth factor beta receptor activity, type II
namespace: molecular_function
def: "Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor." [GOC:mah, Reactome:REACT_6872.1]
synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED []
synonym: "type II TGF-beta receptor activity" EXACT []
synonym: "type II TGFbeta receptor activity" EXACT []
synonym: "type II transforming growth factor beta receptor activity" EXACT []
xref: Reactome:11166 "transforming growth factor beta receptor activity, type II"
is_a: GO:0005024 ! transforming growth factor beta receptor activity

[Term]
id: GO:0005027
name: NGF/TNF (6 C-domain) receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a protein family rather than a molecular function.
is_obsolete: true
consider: GO:0005031

[Term]
id: GO:0005028
name: CD40 receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes the receptor type, and not an activity.
is_obsolete: true
consider: GO:0042615

[Term]
id: GO:0005029
name: CD27 receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes the receptor type, and not an activity.
is_obsolete: true
consider: GO:0042614

[Term]
id: GO:0005030
name: neurotrophin receptor activity
namespace: molecular_function
def: "Combining with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth, to initiate a change in cell activity." [GOC:jl, http://www.mercksource.com/]
is_a: GO:0004872 ! receptor activity
is_a: GO:0043121 ! neurotrophin binding

[Term]
id: GO:0005031
name: tumor necrosis factor receptor activity
namespace: molecular_function
alt_id: GO:0005032
alt_id: GO:0005033
def: "Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function." [GOC:jl, http://lookwayup.com/]
synonym: "NGF/TNF (6 C-domain) receptor activity" NARROW []
synonym: "TNF receptor activity" EXACT []
synonym: "TNF receptor activity, type I" NARROW []
synonym: "TNF receptor activity, type II" NARROW []
synonym: "tumor necrosis factor receptor activity, type I" NARROW []
synonym: "tumor necrosis factor receptor activity, type II" NARROW []
is_a: GO:0005035 ! death receptor activity
is_a: GO:0043120 ! tumor necrosis factor binding

[Term]
id: GO:0005034
name: osmosensor activity
namespace: molecular_function
def: "Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell." [GOC:dph, GOC:tb]
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0005035
name: death receptor activity
namespace: molecular_function
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0005037
name: death receptor adaptor protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
is_obsolete: true
consider: GO:0005123
consider: GO:0005515

[Term]
id: GO:0005038
name: death receptor interacting protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
is_obsolete: true
consider: GO:0005123
consider: GO:0005515

[Term]
id: GO:0005039
name: death receptor-associated factor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
is_obsolete: true
consider: GO:0005123
consider: GO:0005515

[Term]
id: GO:0005040
name: decoy death receptor activity
namespace: molecular_function
is_a: GO:0005035 ! death receptor activity

[Term]
id: GO:0005041
name: low-density lipoprotein receptor activity
namespace: molecular_function
alt_id: GO:0008032
def: "Combining with a low-density lipoprotein to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "LDL receptor" EXACT []
xref: Wikipedia:LDL_receptor
is_a: GO:0030169 ! low-density lipoprotein binding
is_a: GO:0030228 ! lipoprotein receptor activity

[Term]
id: GO:0005042
name: netrin receptor activity
namespace: molecular_function
def: "A transmembrane receptor activity that responds to the netrin family of ligands and results in chemotaxis when activated." [GOC:dph]
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0005043
name: repulsive netrin receptor activity
namespace: molecular_function
def: "A transmembrane receptor activity that responds to the netrin family of ligands and results in chemorepulsion when activated." [GOC:dph]
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0005044
name: scavenger receptor activity
namespace: molecular_function
def: "Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity." [PMID:11790542, PMID:12379907, PMID:12621157]
comment: Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0008329' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms.
subset: gosubset_prok
synonym: "macrophage receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0005045
name: endoplasmic reticulum receptor activity
namespace: molecular_function
def: "OBSOLETE. A receptor in the endoplasmic reticulum." [GOC:ai]
comment: This term was made obsolete because it represents cellular component and molecular function information.
is_obsolete: true
replaced_by: GO:0004872
replaced_by: GO:0005783

[Term]
id: GO:0005046
name: KDEL sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:ai]
synonym: "KDEL receptor activity" NARROW []
is_a: GO:0046923 ! ER retention sequence binding

[Term]
id: GO:0005047
name: signal recognition particle binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the signal recognition particle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: See also the cellular component term 'signal recognition particle, endoplasmic reticulum targeting ; GO:0005786'.
subset: gosubset_prok
synonym: "docking protein" BROAD []
synonym: "signal recognition particle receptor" NARROW []
xref: Reactome:11266 "signal recognition particle binding"
is_a: GO:0043021 ! ribonucleoprotein binding

[Term]
id: GO:0005048
name: signal sequence binding
namespace: molecular_function
alt_id: GO:0008249
def: "Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai]
subset: gosubset_prok
synonym: "leader sequence binding" NARROW []
synonym: "protein signal sequence binding" NARROW []
synonym: "signal sequence receptor" NARROW []
xref: Reactome:11268 "signal sequence binding"
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0005049
name: nuclear export signal receptor activity
namespace: molecular_function
def: "Combining with a nuclear export signal to initiate a change in cell activity." [GOC:ai]
synonym: "NES receptor" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005050
name: peroxisome receptor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes a cellular component.
is_obsolete: true
consider: GO:0004872
consider: GO:0005777

[Term]
id: GO:0005052
name: peroxisome matrix targeting signal-1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L." [GOC:mah, PMID:11687502]
synonym: "peroxisome targeting signal-1 binding" EXACT []
synonym: "peroxisome targeting signal-1 receptor" NARROW []
synonym: "PEX5" NARROW []
synonym: "PTS1 receptor" NARROW []
is_a: GO:0000268 ! peroxisome targeting sequence binding

[Term]
id: GO:0005053
name: peroxisome matrix targeting signal-2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F)." [GOC:mah, PMID:11687502]
synonym: "peroxisome targeting signal-2 binding" EXACT []
synonym: "peroxisome targeting signal-2 receptor" NARROW []
synonym: "PEX7" NARROW []
synonym: "PTS2 receptor" EXACT []
is_a: GO:0000268 ! peroxisome targeting sequence binding

[Term]
id: GO:0005054
name: peroxisome integral membrane receptor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes a cellular component.
synonym: "Pas20p" RELATED []
is_obsolete: true
consider: GO:0004872
consider: GO:0005778

[Term]
id: GO:0005055
name: laminin receptor activity
namespace: molecular_function
def: "Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity." [GOC:ai]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'.
subset: gosubset_prok
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0005056
name: tiggrin receptor activity
namespace: molecular_function
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0005057
name: receptor signaling protein activity
namespace: molecular_function
synonym: "receptor signalling protein activity" EXACT []
is_a: GO:0004871 ! signal transducer activity

[Term]
id: GO:0005061
name: aryl hydrocarbon receptor nuclear translocator activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true

[Term]
id: GO:0005062
name: hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity
namespace: molecular_function
synonym: "gp130" NARROW []
is_a: GO:0005057 ! receptor signaling protein activity

[Term]
id: GO:0005065
name: heterotrimeric G-protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a cellular component and not a molecular function.
is_obsolete: true
replaced_by: GO:0005834

[Term]
id: GO:0005066
name: transmembrane receptor protein tyrosine kinase signaling protein activity
namespace: molecular_function
synonym: "transmembrane receptor protein tyrosine kinase signalling protein activity" EXACT []
is_a: GO:0005057 ! receptor signaling protein activity

[Term]
id: GO:0005068
name: transmembrane receptor protein tyrosine kinase adaptor protein activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a transmembrane receptor protein kinase and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07]
xref: Reactome:11343 "transmembrane receptor protein tyrosine kinase adaptor protein activity"
is_a: GO:0005066 ! transmembrane receptor protein tyrosine kinase signaling protein activity
is_a: GO:0060090 ! molecular adaptor activity

[Term]
id: GO:0005069
name: transmembrane receptor protein tyrosine kinase docking protein activity
namespace: molecular_function
is_a: GO:0005066 ! transmembrane receptor protein tyrosine kinase signaling protein activity

[Term]
id: GO:0005070
name: SH3/SH2 adaptor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68)." [GOC:mah, GOC:so]
synonym: "SH3/SH2 adaptor protein activity" NARROW []
is_a: GO:0004871 ! signal transducer activity
is_a: GO:0030674 ! protein binding, bridging
is_a: GO:0060090 ! molecular adaptor activity

[Term]
id: GO:0005071
name: transmembrane receptor protein serine/threonine kinase signaling protein activity
namespace: molecular_function
synonym: "transmembrane receptor protein serine/threonine kinase signalling protein activity" EXACT []
is_a: GO:0005057 ! receptor signaling protein activity

[Term]
id: GO:0005072
name: transforming growth factor beta receptor, cytoplasmic mediator activity
namespace: molecular_function
def: "Activity of any of the molecules that transmit the signal from a TGF-beta receptor through the cytoplasm to the nucleus." [GOC:hjd]
comment: Note that this term and its children are useful for annotating proteins of the SMAD family.
synonym: "TGF-beta receptor, cytoplasmic mediator activity" EXACT []
synonym: "TGFbeta receptor, cytoplasmic mediator activity" EXACT []
is_a: GO:0005071 ! transmembrane receptor protein serine/threonine kinase signaling protein activity

[Term]
id: GO:0005073
name: common-partner SMAD protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it names a family of gene products.
is_obsolete: true
replaced_by: GO:0030616

[Term]
id: GO:0005074
name: inhibitory SMAD protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it names a family of gene products.
is_obsolete: true
replaced_by: GO:0030617

[Term]
id: GO:0005075
name: pathway-specific SMAD protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a family of gene products.
is_obsolete: true
replaced_by: GO:0030618

[Term]
id: GO:0005076
name: receptor signaling protein serine/threonine kinase signaling protein activity
namespace: molecular_function
synonym: "receptor signalling protein serine/threonine kinase signalling protein activity" EXACT []
is_a: GO:0005057 ! receptor signaling protein activity

[Term]
id: GO:0005077
name: MAP-kinase anchoring activity
namespace: molecular_function
def: "OBSOLETE. Binds to MAP kinase and anchors it to a particular subcellular location." [GOC:ai]
comment: This term was made obsolete because it represents a combination of process and function information.
synonym: "MAP-kinase anchor protein activity" EXACT []
is_obsolete: true
replaced_by: GO:0008104
replaced_by: GO:0051019

[Term]
id: GO:0005078
name: MAP-kinase scaffold activity
namespace: molecular_function
def: "Functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. MAPK scaffold proteins have binding sites for MAPK pathway kinases as well as for upstream signaling proteins." [PMID:12511654]
synonym: "MAP-kinase scaffold protein activity" EXACT []
is_a: GO:0030159 ! receptor signaling complex scaffold activity

[Term]
id: GO:0005079
name: protein kinase A anchoring activity
namespace: molecular_function
def: "OBSOLETE. Binds to protein kinase A and anchors it to a particular subcellular location." [PMID:10354567]
comment: This term was made obsolete because it represents a combination of process and function information.
synonym: "A-kinase anchor protein activity" EXACT []
synonym: "AKAP activity" EXACT []
is_obsolete: true
replaced_by: GO:0008104
replaced_by: GO:0051018

[Term]
id: GO:0005080
name: protein kinase C binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with protein kinase C." [GOC:jl]
synonym: "PKC binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0005081
name: receptor signaling protein serine/threonine phosphatase signaling protein activity
namespace: molecular_function
synonym: "receptor signalling protein serine/threonine phosphatase signalling protein activity" EXACT []
is_a: GO:0005057 ! receptor signaling protein activity

[Term]
id: GO:0005082
name: receptor signaling protein tyrosine phosphatase signaling protein activity
namespace: molecular_function
synonym: "receptor signalling protein tyrosine phosphatase signalling protein activity" EXACT []
is_a: GO:0005057 ! receptor signaling protein activity

[Term]
id: GO:0005083
name: small GTPase regulator activity
namespace: molecular_function
def: "Modulates the rate of GTP hydrolysis by a small monomeric GTPase." [GOC:mah]
subset: gosubset_prok
synonym: "small GTPase regulatory/interacting protein activity" RELATED []
is_a: GO:0030695 ! GTPase regulator activity

[Term]
id: GO:0005085
name: guanyl-nucleotide exchange factor activity
namespace: molecular_function
alt_id: GO:0008433
alt_id: GO:0019839
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
subset: gosubset_prok
synonym: "GEF" EXACT []
synonym: "GNRP" NARROW []
synonym: "guanyl-nucleotide release factor activity" EXACT []
synonym: "guanyl-nucleotide releasing factor" EXACT []
xref: Reactome:11431 "guanyl-nucleotide exchange factor activity"
is_a: GO:0030695 ! GTPase regulator activity

[Term]
id: GO:0005086
name: ARF guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
xref: Reactome:11434 "ARF guanyl-nucleotide exchange factor activity"
is_a: GO:0005083 ! small GTPase regulator activity
is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity

[Term]
id: GO:0005087
name: Ran guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
synonym: "RCC1" EXACT []
xref: Reactome:11435 "Ran guanyl-nucleotide exchange factor activity"
xref: Wikipedia:RCC1
is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity

[Term]
id: GO:0005088
name: Ras guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
xref: Reactome:11436 "Ras guanyl-nucleotide exchange factor activity"
is_a: GO:0005083 ! small GTPase regulator activity
is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity

[Term]
id: GO:0005089
name: Rho guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
synonym: "Rho guanine nucleotide exchange factor" EXACT []
synonym: "RhoGEF" EXACT []
xref: Reactome:11437 "Rho guanyl-nucleotide exchange factor activity"
is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity

[Term]
id: GO:0005090
name: Sar guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Sar family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
comment: Note that the name Sar derives from 'secretion-associated, Ras-related'.
is_a: GO:0005083 ! small GTPase regulator activity
is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity

[Term]
id: GO:0005091
name: guanyl-nucleotide exchange factor adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07]
is_a: GO:0005083 ! small GTPase regulator activity
is_a: GO:0060090 ! molecular adaptor activity

[Term]
id: GO:0005092
name: GDP-dissociation inhibitor activity
namespace: molecular_function
def: "Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah]
synonym: "GDI" EXACT []
is_a: GO:0005083 ! small GTPase regulator activity

[Term]
id: GO:0005093
name: Rab GDP-dissociation inhibitor activity
namespace: molecular_function
def: "Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding." [GOC:mah]
is_a: GO:0005092 ! GDP-dissociation inhibitor activity

[Term]
id: GO:0005094
name: Rho GDP-dissociation inhibitor activity
namespace: molecular_function
def: "Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding." [GOC:mah]
is_a: GO:0005092 ! GDP-dissociation inhibitor activity

[Term]
id: GO:0005095
name: GTPase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate." [GOC:ai]
synonym: "GIP" BROAD []
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0030695 ! GTPase regulator activity

[Term]
id: GO:0005096
name: GTPase activator activity
namespace: molecular_function
def: "Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
subset: gosubset_prok
synonym: "GAP activity" EXACT []
xref: Reactome:11473 "GTPase activator activity"
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0030695 ! GTPase regulator activity

[Term]
id: GO:0005097
name: Rab GTPase activator activity
namespace: molecular_function
def: "Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah]
synonym: "Rab GAP activity" EXACT [GOC:pg]
is_a: GO:0005099 ! Ras GTPase activator activity

[Term]
id: GO:0005098
name: Ran GTPase activator activity
namespace: molecular_function
def: "Increases the rate of GTP hydrolysis by a GTPase of the Ran family." [GOC:mah]
synonym: "Ran GAP activity" EXACT [GOC:pg]
synonym: "RanGAP" RELATED []
is_a: GO:0005099 ! Ras GTPase activator activity

[Term]
id: GO:0005099
name: Ras GTPase activator activity
namespace: molecular_function
def: "Increases the rate of GTP hydrolysis by a GTPase of the Ras superfamily." [GOC:mah]
synonym: "Ras GAP activity" EXACT [GOC:pg]
is_a: GO:0005083 ! small GTPase regulator activity
is_a: GO:0005096 ! GTPase activator activity

[Term]
id: GO:0005100
name: Rho GTPase activator activity
namespace: molecular_function
def: "Increases the rate of GTP hydrolysis by a GTPase of the Rho family." [GOC:mah]
synonym: "Rho GAP activity" EXACT [GOC:pg]
is_a: GO:0005099 ! Ras GTPase activator activity

[Term]
id: GO:0005101
name: Sar GTPase activator activity
namespace: molecular_function
def: "Increases the rate of GTP hydrolysis by a GTPase of the Sar family." [GOC:mah]
comment: Note that the name Sar derives from 'secretion-associated, Ras-related'.
synonym: "Sar GAP activity" EXACT [GOC:pg]
is_a: GO:0005083 ! small GTPase regulator activity
is_a: GO:0005096 ! GTPase activator activity

[Term]
id: GO:0005102
name: receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
synonym: "receptor ligand" NARROW []
synonym: "receptor-associated protein activity" RELATED []
xref: Wikipedia:Ligand_(biochemistry)
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005104
name: fibroblast growth factor receptor binding
namespace: molecular_function
alt_id: GO:0001521
alt_id: GO:0005162
def: "Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR)." [GOC:ceb]
comment: Note that branchless is the Drosophila gene encoding fibroblast growth factor.
synonym: "FGF receptor binding" EXACT []
synonym: "FGFR binding" EXACT []
synonym: "FGFR ligand" NARROW []
synonym: "fibroblast growth factor" BROAD []
synonym: "fibroblast growth factor receptor ligand" NARROW []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005105
name: type 1 fibroblast growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the type 1 fibroblast growth factor receptor (FGFR1)." [GOC:ceb, GOC:fb_curators]
comment: Note that breathless is the Drosophila gene encoding the type 1 fibroblast growth factor receptor (FGFR1).
synonym: "breathless binding" NARROW []
synonym: "breathless ligand" NARROW []
synonym: "FGFR1 binding" BROAD []
synonym: "FGFR1 ligand" NARROW []
synonym: "type 1 fibroblast growth factor receptor ligand" NARROW []
is_a: GO:0005104 ! fibroblast growth factor receptor binding

[Term]
id: GO:0005106
name: ephrin
namespace: molecular_function
def: "OBSOLETE. A class of proteins that interact with the ephrin receptors." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it refers to a class of gene products.
is_obsolete: true
consider: GO:0046875

[Term]
id: GO:0005107
name: GPI-linked ephrin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
is_obsolete: true
consider: GO:0046658
consider: GO:0046875

[Term]
id: GO:0005108
name: transmembrane ephrin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
is_obsolete: true
consider: GO:0005887
consider: GO:0046875

[Term]
id: GO:0005109
name: frizzled binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the frizzled (fz) receptor." [GOC:ceb]
synonym: "frizzled ligand" NARROW []
synonym: "fz binding" EXACT []
synonym: "fz ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0005110
name: frizzled-2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with frizzled-2 (fz2)." [GOC:ceb]
synonym: "frizzled-2 ligand" NARROW []
synonym: "fz2 binding" EXACT []
synonym: "fz2 ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0005111
name: type 2 fibroblast growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the type 2 fibroblast growth factor receptor (FGFR2)." [GOC:fb_curators]
comment: Note that heartless is the Drosophila gene encoding the type 2 fibroblast growth factor receptor (FGFR2).
synonym: "FGFR2 binding" EXACT []
synonym: "FGFR2 ligand" NARROW []
synonym: "heartless binding" EXACT []
synonym: "heartless ligand" NARROW []
synonym: "type 2 fibroblast growth factor receptor ligand" NARROW []
is_a: GO:0005104 ! fibroblast growth factor receptor binding

[Term]
id: GO:0005112
name: Notch binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor." [GOC:ceb]
synonym: "N binding" EXACT []
synonym: "N ligand" NARROW []
synonym: "Notch ligand" NARROW []
synonym: "Notch receptor binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005113
name: patched binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins." [GOC:ceb, PMID:11731473]
synonym: "patched ligand" NARROW []
synonym: "ptc binding" EXACT []
synonym: "ptc ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005114
name: type II transforming growth factor beta receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type II transforming growth factor beta receptor." [GOC:ceb, GOC:mah, PMID:11252892]
synonym: "punt binding" NARROW []
synonym: "punt ligand" NARROW []
synonym: "TGF-beta type II binding" EXACT []
synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED []
synonym: "transforming growth factor beta receptor type II binding" EXACT []
synonym: "type II TGF-beta binding" EXACT []
is_a: GO:0005160 ! transforming growth factor beta receptor binding

[Term]
id: GO:0005115
name: receptor tyrosine kinase-like orphan receptor binding
namespace: molecular_function
def: "Interaction with the receptor tyrosine kinase-like orphan receptor (Ror)." [GOC:ceb]
synonym: "receptor tyrosine kinase-like orphan receptor ligand" NARROW []
synonym: "Ror binding" BROAD []
synonym: "Ror ligand" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005117
name: wishful thinking binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with wishful thinking (Wit), a type II bone morphogenic protein receptor." [GOC:ceb, PMID:11856529]
synonym: "SE20 receptor binding" NARROW []
synonym: "wishful thinking ligand" NARROW []
synonym: "Wit binding" EXACT []
synonym: "Wit ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005118
name: sevenless binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the sevenless (sev) protein, a receptor tyrosine kinase." [FB:gn0003366, GOC:ceb]
synonym: "sev binding" EXACT []
synonym: "sev ligand" NARROW []
synonym: "sevenless ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005119
name: smoothened binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the smoothened (smo) protein, which interacts with patched to transmit hedgehog signals." [GOC:ceb, PMID:11731473]
synonym: "smo binding" EXACT []
synonym: "smo ligand" NARROW []
synonym: "smoothened ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005121
name: Toll binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor." [GOC:ceb]
synonym: "Tl binding" EXACT []
synonym: "Toll ligand" NARROW []
synonym: "Toll receptor binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005122
name: torso binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the torso (tor) protein, a receptor tyrosine kinase." [FB:gn0003733, GOC:ceb]
synonym: "tor binding" EXACT []
synonym: "tor ligand" NARROW []
synonym: "torso ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005123
name: death receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD)." [GOC:ceb, GOC:rl, PMID:15654015]
synonym: "APO binding" NARROW [GOC:rl]
synonym: "death receptor adaptor protein activity" RELATED []
synonym: "death receptor interacting protein activity" RELATED []
synonym: "death receptor ligand" NARROW []
synonym: "death receptor-associated factor activity" RELATED []
synonym: "DR binding" NARROW [GOC:rl]
synonym: "EDAR binding" NARROW [GOC:rl]
synonym: "FAS binding" NARROW [GOC:rl]
synonym: "KILLER binding" NARROW [GOC:rl]
synonym: "NGFR binding" NARROW [GOC:rl]
synonym: "TNFR1 binding" NARROW [GOC:rl]
synonym: "TRAIL binding" NARROW [GOC:rl]
is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding

[Term]
id: GO:0005124
name: scavenger receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles." [GOC:ceb]
synonym: "scavenger receptor ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005125
name: cytokine activity
namespace: molecular_function
def: "Functions to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471]
synonym: "autocrine activity" RELATED [GOC:rl]
synonym: "paracrine activity" RELATED [GOC:rl]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005126
name: cytokine receptor binding
namespace: molecular_function
def: "Interacting selectively with a cytokine receptor." [GOC:mah]
synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor binding" EXACT [GOC:add, GOC:mah]
synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005127
name: ciliary neurotrophic factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor." [GOC:ai]
synonym: "ciliary neurotrophic factor" NARROW []
synonym: "ciliary neurotrophic factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005128
name: erythropoietin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the erythropoietin receptor." [GOC:ai]
synonym: "erythropoietin" NARROW []
synonym: "erythropoietin receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005129
name: granulocyte macrophage colony-stimulating factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the granulocyte macrophage colony-stimulating factor receptor." [GOC:ai]
synonym: "GM-CSF receptor ligand" NARROW []
synonym: "GMC-SF receptor ligand" NARROW []
synonym: "granulocyte macrophage colony-stimulating factor receptor ligand" NARROW []
synonym: "granulocyte-macrophage colony stimulating factor" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005130
name: granulocyte colony-stimulating factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the granulocyte colony-stimulating factor receptor." [GOC:ai]
synonym: "G-CSF receptor ligand" EXACT []
synonym: "GC-SF receptor ligand" EXACT []
synonym: "granulocyte colony-stimulating factor" NARROW []
synonym: "granulocyte colony-stimulating factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005131
name: growth hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the growth hormone receptor." [GOC:ai]
synonym: "growth hormone" NARROW []
synonym: "growth hormone receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0051427 ! hormone receptor binding

[Term]
id: GO:0005132
name: interferon-alpha/beta receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interferon-alpha/beta receptor." [GOC:ai]
synonym: "interferon-alpha/beta" NARROW []
synonym: "interferon-alpha/beta receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005133
name: interferon-gamma receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interferon-gamma receptor." [GOC:ai]
synonym: "interferon-gamma" NARROW []
synonym: "interferon-gamma receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005134
name: interleukin-2 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-2 receptor." [GOC:ai]
synonym: "IL-2" NARROW []
synonym: "interleukin-2 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005135
name: interleukin-3 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-3 receptor." [GOC:ai]
synonym: "IL-3" NARROW []
synonym: "interleukin-3 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005136
name: interleukin-4 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-4 receptor." [GOC:ai]
synonym: "IL-4" NARROW []
synonym: "interleukin-4 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005137
name: interleukin-5 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-5 receptor." [GOC:ai]
synonym: "IL-5" NARROW []
synonym: "interleukin-5 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005138
name: interleukin-6 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-6 receptor." [GOC:ai]
synonym: "IL-6" NARROW []
synonym: "interleukin-6 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005139
name: interleukin-7 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-7 receptor." [GOC:ai]
synonym: "IL-7" NARROW []
synonym: "interleukin-7 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005140
name: interleukin-9 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-9 receptor." [GOC:ai]
synonym: "IL-9" NARROW []
synonym: "interleukin-9 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005141
name: interleukin-10 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-10 receptor." [GOC:ai]
synonym: "IL-10" NARROW []
synonym: "interleukin-10 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005142
name: interleukin-11 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-11 receptor." [GOC:ai]
synonym: "IL-11" NARROW []
synonym: "interleukin-11 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005143
name: interleukin-12 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-12 receptor." [GOC:ai]
synonym: "IL-12" NARROW []
synonym: "interleukin-12 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005144
name: interleukin-13 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-13 receptor." [GOC:ai]
synonym: "IL-13" NARROW []
synonym: "interleukin-13 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005145
name: interleukin-14 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-14 receptor." [GOC:ai]
synonym: "IL-14" NARROW []
synonym: "interleukin-14 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005146
name: leukemia inhibitory factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the leukemia inhibitory factor receptor." [GOC:ai]
synonym: "leukemia inhibitory factor" NARROW []
synonym: "leukemia inhibitory factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005147
name: oncostatin-M receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the oncostatin-M receptor." [GOC:ai]
synonym: "oncostatin-M" NARROW []
synonym: "oncostatin-M receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005148
name: prolactin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the prolactin receptor." [GOC:ai]
synonym: "prolactin" NARROW []
synonym: "prolactin receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005149
name: interleukin-1 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-1 receptor." [GOC:go_curators]
synonym: "IL-1" NARROW []
synonym: "interleukin-1 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005150
name: interleukin-1, Type I receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Type I interleukin-1 receptor." [GOC:ai]
synonym: "IL-1 type I" NARROW []
synonym: "interleukin-1, Type I receptor ligand" NARROW []
is_a: GO:0005149 ! interleukin-1 receptor binding

[Term]
id: GO:0005151
name: interleukin-1, Type II receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Type II interleukin-1 receptor." [GOC:ai]
synonym: "IL-1 type II" NARROW []
synonym: "interleukin-1, Type II receptor ligand" NARROW []
is_a: GO:0005149 ! interleukin-1 receptor binding

[Term]
id: GO:0005152
name: interleukin-1 receptor antagonist activity
namespace: molecular_function
def: "Blocks the binding of interleukin-1 to the interleukin-1 receptor complex." [GOC:ebc]
synonym: "IL-1ra" EXACT []
is_a: GO:0005126 ! cytokine receptor binding
is_a: GO:0030353 ! fibroblast growth factor receptor antagonist activity

[Term]
id: GO:0005153
name: interleukin-8 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-8 receptor." [GOC:go_curators]
synonym: "IL-8" NARROW []
synonym: "interleukin-8 receptor ligand" NARROW []
is_a: GO:0045236 ! CXCR chemokine receptor binding

[Term]
id: GO:0005154
name: epidermal growth factor receptor binding
namespace: molecular_function
alt_id: GO:0008185
def: "Interacting selectively and non-covalently with the epidermal growth factor receptor." [GOC:ai]
synonym: "EGF" NARROW []
synonym: "EGF receptor binding" EXACT []
synonym: "EGF receptor ligand" NARROW []
synonym: "EGFR binding" EXACT []
synonym: "epidermal growth factor" NARROW []
synonym: "epidermal growth factor receptor ligand" NARROW []
synonym: "TGF-alpha receptor binding" EXACT []
synonym: "TGFalpha receptor binding" EXACT []
synonym: "transforming growth factor alpha" NARROW []
synonym: "transforming growth factor alpha receptor binding" EXACT []
synonym: "transforming growth factor alpha receptor ligand" NARROW []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005155
name: epidermal growth factor receptor activating ligand activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was made obsolete because it represents both a biological process and a molecular function.
synonym: "EGF receptor activating ligand activity" EXACT []
synonym: "EGFR activating ligand activity" EXACT []
is_obsolete: true
replaced_by: GO:0005154
consider: GO:0030297
consider: GO:0045741

[Term]
id: GO:0005156
name: epidermal growth factor receptor inhibiting ligand activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:dph, GOC:mah, GOC:tb]
comment: This term was made obsolete because it represents both a biological process and a molecular function.
synonym: "EGF receptor inhibiting ligand activity" EXACT []
synonym: "EGFR inhibiting ligand activity" EXACT []
is_obsolete: true
replaced_by: GO:0005154
consider: GO:0007175
consider: GO:0030293

[Term]
id: GO:0005157
name: macrophage colony stimulating factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the macrophage colony stimulating factor receptor." [GOC:ai]
synonym: "macrophage colony stimulating factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005158
name: insulin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the insulin receptor." [GOC:ai]
synonym: "insulin receptor ligand" NARROW []
is_a: GO:0005102 ! receptor binding
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0005159
name: insulin-like growth factor receptor binding
namespace: molecular_function
alt_id: GO:0005067
def: "Interacting selectively and non-covalently with the insulin-like growth factor receptor." [GOC:jl]
synonym: "IGF receptor binding" EXACT []
synonym: "insulin-like growth factor" NARROW []
synonym: "insulin-like growth factor receptor ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005160
name: transforming growth factor beta receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the transforming growth factor beta receptor." [GOC:ai]
synonym: "activin" RELATED []
synonym: "inhibin" RELATED []
synonym: "TGF-beta receptor binding" EXACT []
synonym: "TGFbeta receptor binding" EXACT []
synonym: "transforming growth factor beta" NARROW []
synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED []
synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED []
synonym: "transforming growth factor beta receptor anchoring activity" RELATED []
synonym: "transforming growth factor beta receptor ligand" NARROW []
xref: Reactome:4078 "transforming growth factor beta receptor binding"
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005161
name: platelet-derived growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the platelet-derived growth factor receptor." [GOC:ai]
synonym: "PDGF" NARROW []
synonym: "PDGF receptor binding" EXACT []
synonym: "PDGFR binding" EXACT []
synonym: "platelet-derived growth factor" NARROW []
synonym: "platelet-derived growth factor receptor ligand" NARROW []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005163
name: nerve growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the nerve growth factor receptor." [GOC:ai, PMID:15654015]
synonym: "nerve growth factor receptor ligand" NARROW []
synonym: "neurotrophin" NARROW []
synonym: "NGF receptor binding" EXACT []
is_a: GO:0005123 ! death receptor binding
is_a: GO:0005165 ! neurotrophin receptor binding

[Term]
id: GO:0005164
name: tumor necrosis factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the tumor necrosis factor receptor." [GOC:ai]
synonym: "TNF receptor binding" EXACT []
synonym: "tumor necrosis factor" NARROW []
synonym: "tumor necrosis factor receptor ligand" NARROW []
is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding

[Term]
id: GO:0005165
name: neurotrophin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neurotrophin receptor." [GOC:ai]
synonym: "neurotrophin" NARROW []
synonym: "neurotrophin receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005166
name: neurotrophin p75 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the neurotrophin p75 receptor." [GOC:ai]
synonym: "neurotrophin p75 receptor ligand" NARROW []
is_a: GO:0005165 ! neurotrophin receptor binding

[Term]
id: GO:0005167
name: neurotrophin TRK receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neurotrophin TRK receptor." [GOC:ai]
synonym: "neurotrophin TRK receptor ligand" NARROW []
is_a: GO:0005165 ! neurotrophin receptor binding

[Term]
id: GO:0005168
name: neurotrophin TRKA receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the neurotrophin TRKA receptor." [GOC:ai]
synonym: "neurotrophin TRKA receptor ligand" NARROW []
is_a: GO:0005167 ! neurotrophin TRK receptor binding

[Term]
id: GO:0005169
name: neurotrophin TRKB receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the neurotrophin TRKB receptor." [GOC:ai]
synonym: "neurotrophin TRKB receptor ligand" NARROW []
is_a: GO:0005167 ! neurotrophin TRK receptor binding

[Term]
id: GO:0005170
name: neurotrophin TRKC receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the neurotrophin TRKC receptor." [GOC:ai]
synonym: "neurotrophin TRKC receptor ligand" NARROW []
is_a: GO:0005167 ! neurotrophin TRK receptor binding

[Term]
id: GO:0005171
name: hepatocyte growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the hepatocyte growth factor receptor." [GOC:ai]
synonym: "hepatocyte growth factor" NARROW []
synonym: "hepatocyte growth factor receptor ligand" NARROW []
synonym: "HGF receptor binding" EXACT []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0005172
name: vascular endothelial growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any vascular endothelial growth factor receptor." [GOC:ai]
synonym: "vascular endothelial growth factor" NARROW []
synonym: "vascular endothelial growth factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005173
name: stem cell factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor." [GOC:jl, PMID:10698217]
synonym: "KIT binding" NARROW []
synonym: "SCF" NARROW []
synonym: "SCFR binding" EXACT []
synonym: "stem cell factor" NARROW []
synonym: "stem cell factor receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0005174
name: CD40 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes." [GOC:jl, ISBN:0120781859]
is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding

[Term]
id: GO:0005175
name: CD27 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CD27, a receptor found on the surface of T cells and some B cells and NK cells." [GOC:jl, ISBN:0120781859]
is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding

[Term]
id: GO:0005176
name: ErbB-2 class receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2." [GOC:jl]
synonym: "ErbB-2 class receptor ligand" NARROW []
synonym: "HER2 receptor binding" EXACT []
synonym: "HER2 receptor ligand" NARROW []
synonym: "Neu receptor binding" EXACT []
synonym: "Neu receptor ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005177
name: neuroligin
namespace: molecular_function
def: "OBSOLETE. A class of ligands for neurexins." [GOC:ai]
is_obsolete: true
consider: GO:0042043

[Term]
id: GO:0005178
name: integrin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an integrin." [GOC:ceb]
synonym: "integrin ligand" NARROW []
is_a: GO:0005102 ! receptor binding
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0005179
name: hormone activity
namespace: molecular_function
def: "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "cAMP generating peptide activity" NARROW []
synonym: "glycopeptide hormone" NARROW []
synonym: "lipopeptide hormone" NARROW []
synonym: "peptide hormone" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005180
name: peptide hormone
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a type of hormone rather than a molecular function.
is_obsolete: true
consider: GO:0005179

[Term]
id: GO:0005181
name: glycopeptide hormone
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a type of hormone rather than a molecular function.
is_obsolete: true
consider: GO:0005179

[Term]
id: GO:0005182
name: lipopeptide hormone
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a type of hormone rather than a molecular function.
is_obsolete: true
consider: GO:0005179

[Term]
id: GO:0005183
name: gonadotropin hormone-releasing hormone activity
namespace: molecular_function
def: "The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, GnRH causes the release of follicle-stimulating hormone and luteinizing hormone by the anterior pituitary." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "GnRH activity" EXACT [ISBN:0198506732]
synonym: "LH/FSH-RF" EXACT [ISBN:0198506732]
synonym: "LHRH activity" EXACT [ISBN:0198506732]
synonym: "luteinizing hormone-releasing factor activity" EXACT [ISBN:0198506732]
synonym: "luteinizing hormone-releasing hormone activity" EXACT [ISBN:0198506732]
synonym: "luteinizing hormone/follicle-stimulating hormone releasing factor activity" EXACT [ISBN:0198506732]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0005184
name: neuropeptide hormone activity
namespace: molecular_function
def: "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]
synonym: "neurohormone" EXACT []
xref: Wikipedia:Neurohormone
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0005185
name: neurohypophyseal hormone activity
namespace: molecular_function
is_a: GO:0005184 ! neuropeptide hormone activity

[Term]
id: GO:0005186
name: pheromone activity
namespace: molecular_function
def: "The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant." [GOC:sgd_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0005187
name: storage protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes a cellular location rather than a function.
is_obsolete: true
replaced_by: GO:0045735

[Term]
id: GO:0005188
name: larval serum protein (sensu Insecta)
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
synonym: "arylphorin" NARROW []
is_obsolete: true

[Term]
id: GO:0005189
name: milk protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
is_obsolete: true

[Term]
id: GO:0005190
name: seminal fluid protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
is_obsolete: true

[Term]
id: GO:0005191
name: acidic epididymal glycoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity.
is_obsolete: true

[Term]
id: GO:0005192
name: urinary protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
is_obsolete: true

[Term]
id: GO:0005193
name: major urinary protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
is_obsolete: true

[Term]
id: GO:0005194
name: cell adhesion molecule activity
namespace: molecular_function
def: "OBSOLETE. Mediates the adhesion of the cell to other cells or to the extracellular matrix." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents gene products involved in the biological process of cell adhesion.
is_obsolete: true
consider: GO:0005102
consider: GO:0005515
consider: GO:0007155
consider: GO:0016021
consider: GO:0030246
consider: GO:0050839

[Term]
id: GO:0005198
name: structural molecule activity
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005199
name: structural constituent of cell wall
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a cell wall." [GOC:mah]
subset: gosubset_prok
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0005200
name: structural constituent of cytoskeleton
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]
subset: gosubset_prok
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0005201
name: extracellular matrix structural constituent
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]
subset: gosubset_prok
synonym: "extracellular matrix glycoprotein" NARROW []
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0005202
name: collagen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
consider: GO:0005581

[Term]
id: GO:0005203
name: proteoglycan
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function.
is_obsolete: true

[Term]
id: GO:0005204
name: chondroitin sulfate proteoglycan
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function.
synonym: "chondroitin sulphate proteoglycan" EXACT []
is_obsolete: true

[Term]
id: GO:0005205
name: chondroitin sulfate/dermatan sulfate proteoglycan
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function.
synonym: "chondroitin sulphate/dermatan sulphate proteoglycan" EXACT []
is_obsolete: true

[Term]
id: GO:0005206
name: heparin sulfate proteoglycan
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "heparin sulphate proteoglycan" EXACT []
is_obsolete: true

[Term]
id: GO:0005207
name: extracellular matrix glycoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes localization and modification rather than activity.
is_obsolete: true
consider: GO:0005201

[Term]
id: GO:0005208
name: amyloid protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true

[Term]
id: GO:0005209
name: plasma protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes presence in body fluids rather than an activity.
is_obsolete: true

[Term]
id: GO:0005211
name: plasma glycoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity.
is_obsolete: true

[Term]
id: GO:0005212
name: structural constituent of eye lens
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0005213
name: structural constituent of chorion
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a chorion. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu]
synonym: "structural protein of chorion" NARROW []
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0005214
name: structural constituent of chitin-based cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0042302 ! structural constituent of cuticle

[Term]
id: GO:0005215
name: transporter activity
namespace: molecular_function
alt_id: GO:0005478
def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells." [GOC:ai, GOC:df]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "small-molecule carrier or transporter" RELATED []
xref: Reactome:1391 "transporter activity"
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005216
name: ion channel activity
namespace: molecular_function
def: "Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729]
subset: goslim_generic
subset: gosubset_prok
is_a: GO:0015075 ! ion transmembrane transporter activity
is_a: GO:0022838 ! substrate-specific channel activity

[Term]
id: GO:0005217
name: intracellular ligand-gated ion channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015276 ! ligand-gated ion channel activity

[Term]
id: GO:0005218
name: intracellular ligand-gated calcium channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005217 ! intracellular ligand-gated ion channel activity
is_a: GO:0015278 ! calcium-release channel activity

[Term]
id: GO:0005219
name: ryanodine-sensitive calcium-release channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:tb]
synonym: "caffeine-sensitive calcium-release channel" RELATED []
synonym: "ryanodine receptor" NARROW []
is_a: GO:0005218 ! intracellular ligand-gated calcium channel activity

[Term]
id: GO:0005220
name: inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate has been bound by the channel complex or one of its constituent parts." [GOC:mah, PMID:8660280]
is_a: GO:0005217 ! intracellular ligand-gated ion channel activity
is_a: GO:0008095 ! inositol-1,4,5-trisphosphate receptor activity
is_a: GO:0015278 ! calcium-release channel activity

[Term]
id: GO:0005221
name: intracellular cyclic nucleotide activated cation channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
is_a: GO:0005217 ! intracellular ligand-gated ion channel activity
is_a: GO:0005261 ! cation channel activity
is_a: GO:0043855 ! cyclic nucleotide-gated ion channel activity

[Term]
id: GO:0005222
name: intracellular cAMP activated cation channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
synonym: "intracellular 3',5' cAMP activated cation channel activity" EXACT []
synonym: "intracellular 3',5'-cAMP activated cation channel activity" EXACT []
synonym: "intracellular adenosine 3',5'-cyclophosphate activated cation channel activity" EXACT []
synonym: "intracellular cyclic AMP activated cation channel activity" EXACT []
is_a: GO:0005221 ! intracellular cyclic nucleotide activated cation channel activity

[Term]
id: GO:0005223
name: intracellular cGMP activated cation channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]
is_a: GO:0005221 ! intracellular cyclic nucleotide activated cation channel activity

[Term]
id: GO:0005224
name: ATP-binding and phosphorylation-dependent chloride channel activity
namespace: molecular_function
is_a: GO:0005217 ! intracellular ligand-gated ion channel activity
is_a: GO:0005254 ! chloride channel activity

[Term]
id: GO:0005225
name: volume-sensitive anion channel activity
namespace: molecular_function
synonym: "volume-regulated channel" BROAD []
is_a: GO:0005253 ! anion channel activity

[Term]
id: GO:0005227
name: calcium activated cation channel activity
namespace: molecular_function
def: "Catalysis of the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]
synonym: "intracellular calcium-activated potassium channel" NARROW []
synonym: "polycystin" NARROW []
is_a: GO:0005261 ! cation channel activity

[Term]
id: GO:0005228
name: intracellular sodium activated potassium channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification." [GOC:mtg_transport, PMID:12628167]
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0022839 ! ion gated channel activity

[Term]
id: GO:0005229
name: intracellular calcium activated chloride channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport]
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0022839 ! ion gated channel activity

[Term]
id: GO:0005230
name: extracellular ligand-gated ion channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015276 ! ligand-gated ion channel activity

[Term]
id: GO:0005231
name: excitatory extracellular ligand-gated ion channel activity
namespace: molecular_function
subset: gosubset_prok
xref: Reactome:4230 "excitatory extracellular ligand-gated ion channel activity"
is_a: GO:0005230 ! extracellular ligand-gated ion channel activity

[Term]
id: GO:0005232
name: serotonin-activated cation-selective channel activity
namespace: molecular_function
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'serotonin receptor activity ; GO:0004993'.
synonym: "5-hydroxytryptamine-gated receptor-channel" EXACT []
is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity
is_a: GO:0005261 ! cation channel activity

[Term]
id: GO:0005234
name: extracellular-glutamate-gated ion channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'.
subset: gosubset_prok
is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity

[Term]
id: GO:0005237
name: inhibitory extracellular ligand-gated ion channel activity
namespace: molecular_function
is_a: GO:0005230 ! extracellular ligand-gated ion channel activity

[Term]
id: GO:0005240
name: glycine receptor-associated protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not describe a molecular function.
is_obsolete: true
consider: GO:0005515

[Term]
id: GO:0005241
name: inward rectifier channel
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
is_obsolete: true
consider: GO:0005242

[Term]
id: GO:0005242
name: inward rectifier potassium channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398]
subset: gosubset_prok
synonym: "Kir channel activity" EXACT [GOC:cb]
is_a: GO:0005249 ! voltage-gated potassium channel activity
is_a: GO:0015276 ! ligand-gated ion channel activity

[Term]
id: GO:0005243
name: gap junction channel activity
namespace: molecular_function
alt_id: GO:0015285
alt_id: GO:0015286
def: "A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes." [GOC:dgh, GOC:mtg_transport, ISBN:0815340729]
synonym: "connexin" RELATED []
synonym: "innexin" NARROW []
synonym: "innexin channel activity" EXACT []
synonym: "intercellular channel" BROAD []
xref: Reactome:13185 "gap junction channel activity"
is_a: GO:0022829 ! wide pore channel activity

[Term]
id: GO:0005244
name: voltage-gated ion channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
synonym: "voltage gated ion channel activity" EXACT []
synonym: "voltage-dependent ion channel activity" EXACT []
is_a: GO:0005216 ! ion channel activity
is_a: GO:0022832 ! voltage-gated channel activity

[Term]
id: GO:0005245
name: voltage-gated calcium channel activity
namespace: molecular_function
alt_id: GO:0010173
def: "Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel." [GOC:mtg_transport, GOC:tb, ISBN:0815340729]
synonym: "depolarization-activated calcium channel" BROAD []
synonym: "depolarization-activated voltage gated calcium channel activity" EXACT []
synonym: "depolarization-activated voltage-gated calcium channel" EXACT []
synonym: "depolarization-activated voltage-gated calcium channel activity" EXACT []
synonym: "voltage gated calcium channel activity" EXACT []
synonym: "voltage-dependent calcium channel activity" EXACT []
synonym: "voltage-gated calcium ion channel activity" EXACT []
synonym: "voltage-sensitive calcium channel" EXACT []
xref: Reactome:13187 "voltage-gated calcium channel activity"
is_a: GO:0005262 ! calcium channel activity
is_a: GO:0022843 ! voltage-gated cation channel activity

[Term]
id: GO:0005246
name: calcium channel regulator activity
namespace: molecular_function
def: "Modulates the activity of a calcium channel." [GOC:mah]
is_a: GO:0016247 ! channel regulator activity

[Term]
id: GO:0005247
name: voltage-gated chloride channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "voltage gated chloride channel activity" EXACT []
synonym: "voltage-dependent chloride channel activity" EXACT []
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0008308 ! voltage-gated anion channel activity

[Term]
id: GO:0005248
name: voltage-gated sodium channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729]
synonym: "voltage gated sodium channel activity" EXACT []
synonym: "voltage-dependent sodium channel activity" EXACT []
synonym: "voltage-gated sodium ion channel activity" EXACT []
synonym: "voltage-sensitive sodium channel" EXACT []
is_a: GO:0005272 ! sodium channel activity
is_a: GO:0022843 ! voltage-gated cation channel activity

[Term]
id: GO:0005249
name: voltage-gated potassium channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "voltage gated potassium channel activity" EXACT []
synonym: "voltage-dependent potassium channel activity" EXACT []
synonym: "voltage-gated potassium ion channel activity" EXACT []
synonym: "voltage-sensitive potassium channel" EXACT []
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0022843 ! voltage-gated cation channel activity

[Term]
id: GO:0005250
name: A-type (transient outward) potassium channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential." [GOC:mah, PMID:5575340]
is_a: GO:0015271 ! outward rectifier potassium channel activity

[Term]
id: GO:0005251
name: delayed rectifier potassium channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and activation is slow." [GOC:mah, PMID:11343411, PMID:2462513]
is_a: GO:0005249 ! voltage-gated potassium channel activity

[Term]
id: GO:0005252
name: open rectifier potassium channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration." [GOC:mah, PMID:8917578]
is_a: GO:0005249 ! voltage-gated potassium channel activity

[Term]
id: GO:0005253
name: anion channel activity
namespace: molecular_function
def: "Catalysis of the energy-independent passage of anions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0005216 ! ion channel activity
is_a: GO:0008509 ! anion transmembrane transporter activity

[Term]
id: GO:0005254
name: chloride channel activity
namespace: molecular_function
def: "Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0005253 ! anion channel activity

[Term]
id: GO:0005260
name: channel-conductance-controlling ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels." [EC:3.6.3.49]
synonym: "ATP phosphohydrolase (channel-conductance-controlling)" EXACT [EC:3.6.3.49]
synonym: "cystic fibrosis transmembrane conductance regulator" NARROW []
synonym: "cystic-fibrosis membrane-conductance-regulating protein activity" NARROW [EC:3.6.3.49]
xref: EC:3.6.3.49
xref: MetaCyc:3.6.3.49-RXN
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0005261
name: cation channel activity
namespace: molecular_function
alt_id: GO:0015281
alt_id: GO:0015338
def: "Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "cation diffusion facilitator activity" EXACT []
synonym: "nonselective cation channel activity" EXACT []
xref: Reactome:13089 "cation channel activity"
is_a: GO:0005216 ! ion channel activity
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0005262
name: calcium channel activity
namespace: molecular_function
def: "Catalysis of facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:13088 "calcium channel activity"
is_a: GO:0005261 ! cation channel activity

[Term]
id: GO:0005267
name: potassium channel activity
namespace: molecular_function
def: "Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0005261 ! cation channel activity

[Term]
id: GO:0005272
name: sodium channel activity
namespace: molecular_function
def: "Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005261 ! cation channel activity

[Term]
id: GO:0005274
name: allantoin uptake transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015206
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.39.3.1]
synonym: "allantoin permease activity" RELATED []
synonym: "allantoin/allantoate transporter" BROAD []
is_a: GO:0015391 ! nucleobase:cation symporter activity
is_a: GO:0015563 ! uptake transmembrane transporter activity

[Term]
id: GO:0005275
name: amine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005279
def: "Catalysis of the transfer of amines, including polyamines, from one side of the membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
synonym: "amine/amide/polyamine channel activity" BROAD []
synonym: "amine/polyamine transmembrane transporter activity" EXACT []
synonym: "amino acid-polyamine transmembrane transporter activity" EXACT []
is_a: GO:0022804 ! active transmembrane transporter activity
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0005276
name: hydrogen:vesicular amine antiporter activity
namespace: molecular_function
is_a: GO:0005275 ! amine transmembrane transporter activity
is_a: GO:0015299 ! solute:hydrogen antiporter activity

[Term]
id: GO:0005277
name: acetylcholine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of acetylcholine from one side of the membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
xref: Reactome:13291 "acetylcholine transmembrane transporter activity"
is_a: GO:0005275 ! amine transmembrane transporter activity
is_a: GO:0005326 ! neurotransmitter transporter activity

[Term]
id: GO:0005278
name: acetylcholine:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out)." [TC:2.A.1.2.13]
synonym: "acetylcholine:proton antiporter activity" EXACT []
is_a: GO:0005277 ! acetylcholine transmembrane transporter activity
is_a: GO:0015299 ! solute:hydrogen antiporter activity

[Term]
id: GO:0005280
name: hydrogen:amino acid symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in)." [GOC:ai]
subset: gosubset_prok
synonym: "cation/amino acid symporter" BROAD []
is_a: GO:0005416 ! cation:amino acid symporter activity
is_a: GO:0015295 ! solute:hydrogen symporter activity

[Term]
id: GO:0005281
name: general amino acid permease activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "general amino acid transporter" BROAD []
is_obsolete: true
replaced_by: GO:0015171

[Term]
id: GO:0005283
name: sodium:amino acid symporter activity
namespace: molecular_function
alt_id: GO:0005285
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)." [GOC:ai]
subset: gosubset_prok
synonym: "glutamate/aspartate:sodium symporter activity" NARROW []
synonym: "isoleucine/valine:sodium symporter activity" NARROW []
synonym: "sodium/amino acid transporter activity" BROAD []
synonym: "sodium/excitatory amino acid cotransporter activity" BROAD []
synonym: "sodium/excitatory amino acid symporter activity" EXACT []
synonym: "sodium:amino acid transporter activity" BROAD []
synonym: "threonine/serine:sodium symporter activity" NARROW []
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0005416 ! cation:amino acid symporter activity

[Term]
id: GO:0005284
name: insulin-activated sodium:amino acid symporter activity
namespace: molecular_function
synonym: "insulin-activated sodium/amino acid transporter activity" EXACT []
synonym: "insulin-activated sodium:amino acid transporter activity" EXACT []
is_a: GO:0005283 ! sodium:amino acid symporter activity

[Term]
id: GO:0005287
name: high affinity basic amino acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high-affinity basic amino acid transporter activity" BROAD []
is_a: GO:0015174 ! basic amino acid transmembrane transporter activity

[Term]
id: GO:0005289
name: high affinity arginine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of arginine from one side of a membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high-affinity arginine transporter activity" BROAD []
is_a: GO:0005287 ! high affinity basic amino acid transmembrane transporter activity
is_a: GO:0015181 ! arginine transmembrane transporter activity

[Term]
id: GO:0005290
name: L-histidine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW []
synonym: "L-histidine transporter activity" BROAD []
is_a: GO:0015174 ! basic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0005291
name: high affinity L-histidine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high affinity histidine permease activity" RELATED []
is_a: GO:0005287 ! high affinity basic amino acid transmembrane transporter activity
is_a: GO:0005290 ! L-histidine transmembrane transporter activity

[Term]
id: GO:0005292
name: high affinity lysine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of lysine from one side of a membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high affinity lysine transporter activity" BROAD []
is_a: GO:0005287 ! high affinity basic amino acid transmembrane transporter activity
is_a: GO:0015189 ! L-lysine transmembrane transporter activity

[Term]
id: GO:0005294
name: neutral L-amino acid secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
subset: gosubset_prok
synonym: "neutral L-amino acid porter activity" RELATED []
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0005295
name: neutral amino acid:sodium symporter activity
namespace: molecular_function
alt_id: GO:0005282
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral amino acid(out) + Na+(out) = neutral amino acid(in) + Na+(in)." [TC:2.A.23.3.1]
synonym: "neutral amino acid-sodium cotransporter" BROAD []
synonym: "sodium/neutral amino acid transporter" BROAD []
is_a: GO:0005283 ! sodium:amino acid symporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity

[Term]
id: GO:0005297
name: hydrogen:proline symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in)." [GOC:ai]
synonym: "hydrogen/proline transporter" BROAD []
is_a: GO:0005280 ! hydrogen:amino acid symporter activity
is_a: GO:0015193 ! L-proline transmembrane transporter activity

[Term]
id: GO:0005298
name: proline:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in)." [TC:2.A.22.2.1]
subset: gosubset_prok
synonym: "sodium/proline symporter activity" EXACT []
is_a: GO:0005283 ! sodium:amino acid symporter activity
is_a: GO:0015193 ! L-proline transmembrane transporter activity

[Term]
id: GO:0005300
name: high-affinity tryptophan transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:mtg_transport, ISBN:0815340729]
synonym: "high-affinity tryptophan transporter activity" BROAD []
is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity

[Term]
id: GO:0005301
name: valine/tyrosine/tryptophan permease activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "hydrogen/valine-tyrosine-tryptophan transporter" EXACT []
is_obsolete: true
consider: GO:0005302
consider: GO:0005304
consider: GO:0015196
consider: GO:0022857

[Term]
id: GO:0005302
name: L-tyrosine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015508
def: "Catalysis of the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-tyrosine permease activity" EXACT []
synonym: "L-tyrosine transporter activity" BROAD []
synonym: "valine/tyrosine/tryptophan permease activity" RELATED []
is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0005304
name: L-valine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "isoleucine/valine:sodium symporter activity" NARROW []
synonym: "L-valine transporter activity" BROAD []
synonym: "leucine/isoleucine/valine porter activity" NARROW []
synonym: "leucine/valine/isoleucine permease activity" NARROW []
synonym: "valine/tyrosine/tryptophan permease activity" NARROW []
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0005307
name: choline:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)." [TC:2.A.22.3.5]
synonym: "sodium/choline symporter activity" EXACT []
is_a: GO:0015220 ! choline transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005308
name: creatine transporter activity
namespace: molecular_function
def: "Enables the directed movement of creatine into, out of, within or between cells. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai]
is_a: GO:0051184 ! cofactor transporter activity

[Term]
id: GO:0005309
name: creatine:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in)." [TC:2.A.22.3.4]
synonym: "sodium/chloride-dependent creatine transporter" BROAD []
xref: Reactome:14013 "creatine:sodium symporter activity"
is_a: GO:0005308 ! creatine transporter activity
is_a: GO:0005328 ! neurotransmitter:sodium symporter activity

[Term]
id: GO:0005310
name: dicarboxylic acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005312
alt_id: GO:0015365
def: "Catalysis of the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups." [GOC:ai]
subset: gosubset_prok
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW []
synonym: "dicarboxylate carrier" NARROW []
synonym: "dicarboxylic acid permease activity" RELATED []
synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW []
xref: Reactome:14021 "dicarboxylic acid transmembrane transporter activity"
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0005311
name: sodium:dicarboxylate/tricarboxylate symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (dicarboxylate or tricarboxylate)(out) + Na+(out) = (dicarboxylate or tricarboxylate)(in) + Na+(in)." [TC:2.A.47.1.5]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "sodium:dicarboxylate/tricarboxylate cotransporter activity" BROAD []
is_obsolete: true
consider: GO:0005310
consider: GO:0005343
consider: GO:0015142

[Term]
id: GO:0005313
name: L-glutamate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "glutamate/aspartate porter activity" NARROW []
synonym: "glutamate/aspartate:sodium symporter activity" NARROW []
synonym: "L-glutamate transporter activity" BROAD []
xref: Reactome:13352 "L-glutamate transmembrane transporter activity"
is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0005314
name: high-affinity glutamate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in)." [TC:2.A.3.10.5]
synonym: "high-affinity glutamate transporter activity" BROAD []
is_a: GO:0005313 ! L-glutamate transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005315
name: inorganic phosphate transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005317
def: "Catalysis of the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
subset: gosubset_prok
is_a: GO:0015114 ! phosphate transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0005316
name: high affinity inorganic phosphate:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in)." [TC:2.A.20.2.2]
synonym: "sodium/phosphate cotransporter activity" BROAD []
is_a: GO:0005436 ! sodium:phosphate symporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005318
name: phosphate:hydrogen symporter
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
synonym: "phosphate:proton symporter activity" EXACT []
is_obsolete: true
consider: GO:0015317

[Term]
id: GO:0005319
name: lipid transporter activity
namespace: molecular_function
def: "Enables the directed movement of lipids into, out of, within or between cells." [GOC:ai]
subset: gosubset_prok
synonym: "apolipoprotein" RELATED []
synonym: "lipophorin" NARROW []
xref: Reactome:7042 "lipid transporter activity"
is_a: GO:0022892 ! substrate-specific transporter activity

[Term]
id: GO:0005320
name: apolipoprotein
namespace: molecular_function
alt_id: GO:0015907
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
consider: GO:0005319

[Term]
id: GO:0005321
name: high-density lipoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "HDL" EXACT []
is_obsolete: true
replaced_by: GO:0005319

[Term]
id: GO:0005322
name: low-density lipoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "LDL" EXACT []
is_obsolete: true
replaced_by: GO:0005319

[Term]
id: GO:0005323
name: very-low-density lipoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
synonym: "VLDL" EXACT []
is_obsolete: true
replaced_by: GO:0005319

[Term]
id: GO:0005324
name: long-chain fatty acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of long-chain fatty acids into, out of, within or between cells. Long-chain fatty acids have a chain length of greater than 12 carbons." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "plasma membrane long-chain fatty acid transporter" NARROW []
xref: Reactome:14049 "long-chain fatty acid transporter activity"
is_a: GO:0015245 ! fatty acid transporter activity

[Term]
id: GO:0005325
name: peroxisomal fatty acyl CoA transporter activity
namespace: molecular_function
alt_id: GO:0008562
def: "Catalysis of the reaction: ATP + H2O + fatty acyl CoA(cis) = ADP + phosphate + fatty acyl CoA(trans). The transport of fatty acyl CoA into and out of peroxisomes." [EC:3.6.3.47]
synonym: "ATP phosphohydrolase (fatty-acyl-CoA-transporting)" EXACT [EC:3.6.3.47]
synonym: "fatty-acyl-CoA-transporting ATPase" BROAD []
xref: EC:3.6.3.47
xref: Reactome:14052 "peroxisomal fatty acyl CoA transporter activity"
is_a: GO:0005324 ! long-chain fatty acid transporter activity
is_a: GO:0015607 ! fatty acyl CoA transporter activity

[Term]
id: GO:0005326
name: neurotransmitter transporter activity
namespace: molecular_function
def: "Enables the directed movement of a neurotransmitter into, out of, within or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_generic
subset: gosubset_prok
synonym: "neurotransmitter transmembrane transporter activity" EXACT [GOC:mah]
xref: Reactome:13292 "neurotransmitter transporter activity"
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0005328
name: neurotransmitter:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]
subset: gosubset_prok
synonym: "sodium/neurotransmitter symporter activity" EXACT []
is_a: GO:0005326 ! neurotransmitter transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005329
name: dopamine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of dopamine from one side of the membrane to the other. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
is_a: GO:0008504 ! monoamine transmembrane transporter activity

[Term]
id: GO:0005330
name: dopamine:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) = dopamine(in) + Na+(in)." [TC:2.A.22.1.3]
synonym: "sodium/dopamine symporter activity" EXACT []
is_a: GO:0005328 ! neurotransmitter:sodium symporter activity
is_a: GO:0005329 ! dopamine transmembrane transporter activity

[Term]
id: GO:0005332
name: gamma-aminobutyric acid:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) = gamma-aminobutyric acid(in) + Na+(in)." [TC:2.A.22.3.2]
comment: See also the molecular function term 'neurotransmitter:sodium symporter activity ; GO:0005328'.
synonym: "4-aminobutanoate:sodium symporter activity" EXACT []
synonym: "4-aminobutyrate:sodium symporter activity" EXACT []
synonym: "betaine/GABA:sodium symporter activity" EXACT []
synonym: "GABA:sodium symporter activity" EXACT []
synonym: "sodium/chloride-dependent GABA transporter activity" BROAD []
is_a: GO:0005283 ! sodium:amino acid symporter activity
is_a: GO:0015185 ! L-gamma-aminobutyric acid transmembrane transporter activity

[Term]
id: GO:0005333
name: norepinephrine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of norepinephrine from one side of the membrane to the other. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "levarterenol transporter activity" EXACT []
synonym: "noradrenaline transporter activity" EXACT []
xref: Wikipedia:Norepinephrine_transporter
is_a: GO:0008504 ! monoamine transmembrane transporter activity

[Term]
id: GO:0005334
name: norephinephrine:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) = norepinephrine(in) + Na+(in)." [TC:2.A.22.1.2]
synonym: "noradrenaline:sodium symporter activity" EXACT []
synonym: "sodium/norepinephrine symporter activity" EXACT []
is_a: GO:0005328 ! neurotransmitter:sodium symporter activity
is_a: GO:0005333 ! norepinephrine transmembrane transporter activity

[Term]
id: GO:0005335
name: serotonin:sodium symporter activity
namespace: molecular_function
alt_id: GO:0005336
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) = serotonin(in) + Na+(in)." [TC:2.A.22.1.1]
synonym: "sodium/serotonin symporter activity" EXACT []
is_a: GO:0005328 ! neurotransmitter:sodium symporter activity

[Term]
id: GO:0005337
name: nucleoside transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "intracellular nucleoside transmembrane transporter activity" NARROW []
is_a: GO:0015932 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity

[Term]
id: GO:0005338
name: nucleotide-sugar transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005339
def: "Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926]
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity

[Term]
id: GO:0005340
name: nucleotide-sulfate transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005341
def: "Catalysis of the transfer of nucleotide-sulfate from one side of a membrane to the other." [GOC:mtg_transport]
synonym: "nucleotide-sulphate transporter activity" EXACT []
is_a: GO:0015116 ! sulfate transmembrane transporter activity

[Term]
id: GO:0005342
name: organic acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0005343
name: organic acid:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)." [TC:2.A.28.1.1]
subset: gosubset_prok
synonym: "sodium/chloride-dependent organic acid cotransporter activity" RELATED []
synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW []
is_a: GO:0005342 ! organic acid transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005344
name: oxygen transporter activity
namespace: molecular_function
alt_id: GO:0015033
def: "Enables the directed movement of oxygen into, out of, within or between cells." [GOC:ai]
subset: gosubset_prok
synonym: "globin" NARROW []
synonym: "hemerythrin" NARROW []
synonym: "hemocyanin" NARROW []
synonym: "oxygen-carrying" NARROW []
is_a: GO:0022892 ! substrate-specific transporter activity

[Term]
id: GO:0005345
name: purine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of purines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015205 ! nucleobase transmembrane transporter activity

[Term]
id: GO:0005346
name: purine ribonucleotide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity

[Term]
id: GO:0005347
name: ATP transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005348
def: "Catalysis of the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity

[Term]
id: GO:0005350
name: pyrimidine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of pyrimidines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015205 ! nucleobase transmembrane transporter activity

[Term]
id: GO:0005351
name: sugar:hydrogen symporter activity
namespace: molecular_function
alt_id: GO:0005403
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]
subset: gosubset_prok
synonym: "cation/sugar symporter activity" BROAD []
synonym: "hydrogen:sugar symporter activity" EXACT []
synonym: "hydrogen:sugar transporter activity" BROAD []
synonym: "proton:sugar symporter activity" EXACT []
synonym: "sugar porter activity" RELATED []
synonym: "sugar transporter" BROAD []
synonym: "sugar:hydrogen ion symporter activity" EXACT []
is_a: GO:0005402 ! cation:sugar symporter activity
is_a: GO:0015295 ! solute:hydrogen symporter activity
is_a: GO:0051119 ! sugar transmembrane transporter activity

[Term]
id: GO:0005352
name: alpha-glucoside:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose." [TC:2.A.1.1.11]
synonym: "general alpha-glucoside transporter activity" BROAD []
synonym: "general alpha-glucoside:hydrogen symporter activity" EXACT []
synonym: "general alpha-glucoside:proton symporter activity" EXACT []
is_a: GO:0005402 ! cation:sugar symporter activity
is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity

[Term]
id: GO:0005353
name: fructose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015585
alt_id: GO:0019192
def: "Catalysis of the transfer of fructose from one side of the membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "fructose permease activity" EXACT []
synonym: "fructose porter activity" EXACT []
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0005354
name: galactose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of galactose from one side of the membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "galactose/glucose (methylgalactoside) porter activity" NARROW []
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0005355
name: glucose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015579
def: "Catalysis of the transfer of the hexose monosaccharide glucose from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "galactose/glucose (methylgalactoside) porter activity" NARROW []
synonym: "glucose permease activity" EXACT []
synonym: "lactose/glucose efflux transporter activity" NARROW []
xref: Reactome:14118 "glucose transmembrane transporter activity"
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0005356
name: hydrogen:glucose symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport]
synonym: "hydrogen:glucose transporter activity" RELATED []
is_a: GO:0005355 ! glucose transmembrane transporter activity
is_a: GO:0009679 ! hexose:hydrogen symporter activity

[Term]
id: GO:0005357
name: constitutive hydrogen:glucose symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport]
synonym: "constitutive hydrogen/glucose transporter activity" BROAD []
synonym: "constitutive hydrogen:glucose transporter activity" BROAD []
is_a: GO:0005356 ! hydrogen:glucose symporter activity

[Term]
id: GO:0005358
name: high-affinity hydrogen:glucose symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high-affinity hydrogen/glucose transporter activity" BROAD []
synonym: "high-affinity hydrogen:glucose transporter activity" BROAD []
is_a: GO:0005356 ! hydrogen:glucose symporter activity

[Term]
id: GO:0005359
name: low-affinity hydrogen:glucose symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport]
synonym: "low-affinity hydrogen/glucose transporter activity" BROAD []
synonym: "low-affinity hydrogen:glucose transporter activity" BROAD []
is_a: GO:0005356 ! hydrogen:glucose symporter activity

[Term]
id: GO:0005360
name: insulin-responsive hydrogen:glucose symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport]
synonym: "insulin-responsive hydrogen:glucose transporter activity" RELATED []
synonym: "transepithelial hydrogen/glucose transporter activity" RELATED []
is_a: GO:0005356 ! hydrogen:glucose symporter activity

[Term]
id: GO:0005361
name: transepithelial hydrogen:glucose symporter activity
namespace: molecular_function
synonym: "transepithelial hydrogen/glucose transporter activity" BROAD []
synonym: "transepithelial hydrogen:glucose transporter activity" BROAD []
is_a: GO:0005356 ! hydrogen:glucose symporter activity

[Term]
id: GO:0005362
name: low-affinity glucose:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.21.3.-]
synonym: "low-affinity glucose-sodium cotransporter activity" BROAD []
is_a: GO:0005412 ! glucose:sodium symporter activity

[Term]
id: GO:0005363
name: maltose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015581
def: "Catalysis of the transfer of maltose from one side of the membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
synonym: "maltose porter activity" EXACT []
is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity
is_a: GO:0015154 ! disaccharide transmembrane transporter activity

[Term]
id: GO:0005364
name: maltose:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in)." [TC:2.A.1.1.10]
synonym: "hydrogen/maltose transporter activity" BROAD []
synonym: "maltose permease" BROAD []
synonym: "maltose:proton symporter activity" EXACT []
is_a: GO:0005351 ! sugar:hydrogen symporter activity
is_a: GO:0005363 ! maltose transmembrane transporter activity

[Term]
id: GO:0005365
name: myo-inositol transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of myo-inositol from one side of the membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin Bh transporter activity" EXACT []
is_a: GO:0015166 ! polyol transmembrane transporter activity

[Term]
id: GO:0005366
name: myo-inositol:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in)." [TC:2.A.1.1.8]
synonym: "hydrogen/myo-inositol transporter activity" BROAD []
synonym: "myo-inositol:proton symporter activity" EXACT []
is_a: GO:0005365 ! myo-inositol transmembrane transporter activity
is_a: GO:0015295 ! solute:hydrogen symporter activity

[Term]
id: GO:0005367
name: myo-inositol:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in)." [TC:2.A.21.4.-]
synonym: "myo-inositol-sodium cotransporter activity" BROAD []
is_a: GO:0005365 ! myo-inositol transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005368
name: taurine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of taurine from one side of the membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005275 ! amine transmembrane transporter activity
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0005369
name: taurine:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)." [TC:2.A.22.3.3]
synonym: "sodium/chloride-dependent taurine transporter" BROAD []
is_a: GO:0005328 ! neurotransmitter:sodium symporter activity
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0005368 ! taurine transmembrane transporter activity

[Term]
id: GO:0005371
name: tricarboxylate secondary active transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005370
def: "Catalysis of the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "citrate carrier" EXACT []
synonym: "tricarboxylate carrier activity" EXACT []
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0005372
name: water transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of water (H2O) from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0005373
name: heavy metal ion porter activity
namespace: molecular_function
def: "OBSOLETE. A transporter of heavy metal ions that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "metal ion transporter" BROAD []
is_obsolete: true
consider: GO:0015291
consider: GO:0046873

[Term]
id: GO:0005375
name: copper ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005378
alt_id: GO:0005379
alt_id: GO:0005380
def: "Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "intracellular copper ion transporter" NARROW []
synonym: "plasma membrane copper transporter" NARROW []
is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0005376
name: plasma membrane copper transporter
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
is_obsolete: true
consider: GO:0005375
consider: GO:0005886

[Term]
id: GO:0005377
name: intracellular copper ion transporter
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
synonym: "intracellular copper transporter" EXACT []
is_obsolete: true
replaced_by: GO:0005375
replaced_by: GO:0005622

[Term]
id: GO:0005381
name: iron ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005382
alt_id: GO:0016033
def: "Catalysis of the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "iron transporter activity" EXACT []
synonym: "multicopper ferroxidase iron transport mediator activity" RELATED []
synonym: "transmembrane iron ion permease activity" EXACT []
synonym: "transmembrane iron permease activity" EXACT []
synonym: "zinc, iron permease activity" RELATED []
is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0005384
name: manganese ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:df]
subset: gosubset_prok
is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0005385
name: zinc ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:df]
subset: gosubset_prok
synonym: "cobalt, zinc uptake permease activity" NARROW []
synonym: "zinc, cadmium uptake permease activity" NARROW []
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW []
synonym: "zinc, iron permease activity" NARROW []
xref: Reactome:14183 "zinc ion transmembrane transporter activity"
is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0005388
name: calcium-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (Ca2+-transporting)" EXACT [EC:3.6.3.8]
synonym: "Ca(2+)-transporting ATPase activity" EXACT [EC:3.6.3.8]
synonym: "Ca2+-pumping ATPase activity" EXACT [EC:3.6.3.8]
synonym: "Ca2+-transporting ATPase activity" EXACT [EC:3.6.3.8]
synonym: "calcium ABC transporter" NARROW []
synonym: "calcium efflux ATPase" NARROW []
synonym: "calcium pump" BROAD []
synonym: "calcium transporting ATPase activity" EXACT []
synonym: "calcium-translocating P-type ATPase activity" NARROW [EC:3.6.3.8]
synonym: "plasma membrane Ca-ATPase" NARROW [EC:3.6.3.8]
synonym: "sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [EC:3.6.3.8]
synonym: "sarcoplasmic reticulum ATPase" NARROW []
xref: EC:3.6.3.8
xref: MetaCyc:3.6.3.8-RXN
is_a: GO:0015085 ! calcium ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0005391
name: sodium:potassium-exchanging ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:3.6.3.9]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "(Na+ + K+)-activated ATPase activity" EXACT [EC:3.6.3.9]
synonym: "(Na+ + K+)-ATPase activity" EXACT [EC:3.6.3.9]
synonym: "ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [EC:3.6.3.9]
synonym: "Na(+)/K(+)-ATPase activity" EXACT [EC:3.6.3.9]
synonym: "Na(+)/K(+)-exchanging ATPase activity" EXACT [EC:3.6.3.9]
synonym: "Na+,K+ pump" RELATED [EC:3.6.3.9]
synonym: "Na+,K+-ATPase activity" EXACT [EC:3.6.3.9]
synonym: "Na+/K+-ATPase activity" EXACT [EC:3.6.3.9]
synonym: "Na+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.9]
synonym: "na+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.9]
synonym: "Na,K-activated ATPase activity" EXACT [EC:3.6.3.9]
synonym: "Na,K-pump" RELATED [EC:3.6.3.9]
synonym: "sodium pump" BROAD []
synonym: "sodium/potassium-exchanging ATPase activity" EXACT []
synonym: "sodium/potassium-transporting ATPase activity" EXACT [EC:3.6.3.9]
synonym: "sodium:potassium exchanging ATPase activity" EXACT []
xref: EC:3.6.3.9
xref: MetaCyc:3.6.3.9-RXN
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

[Term]
id: GO:0005395
name: eye pigment precursor transporter activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out)." [TC:3.A.1.204.1]
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0005396
name: transmembrane conductance regulator activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because its meaning was ambiguous, it was undefined and its position in the tree wrong.
is_obsolete: true
consider: GO:0043267

[Term]
id: GO:0005400
name: peroxisomal membrane transporter
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
is_obsolete: true
consider: GO:0005215
consider: GO:0005777

[Term]
id: GO:0005402
name: cation:sugar symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in)." [GOC:ai]
subset: gosubset_prok
synonym: "cation/sugar symporter activity" EXACT []
synonym: "sugar:cation symporter activity" EXACT []
is_a: GO:0015294 ! solute:cation symporter activity

[Term]
id: GO:0005412
name: glucose:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-]
synonym: "sodium/glucose symporter activity" EXACT []
is_a: GO:0005355 ! glucose transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005415
name: nucleoside:sodium symporter activity
namespace: molecular_function
alt_id: GO:0008522
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in)." [GOC:ai]
subset: gosubset_prok
synonym: "nucleoside-sodium cotransporter activity" BROAD []
synonym: "sodium-dependent nucleoside transporter activity" BROAD []
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0005416
name: cation:amino acid symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)." [GOC:ai]
subset: gosubset_prok
synonym: "cation/amino acid symporter activity" EXACT []
is_a: GO:0005275 ! amine transmembrane transporter activity
is_a: GO:0015294 ! solute:cation symporter activity

[Term]
id: GO:0005427
name: proton-dependent oligopeptide secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport, OMIM:600544]
subset: gosubset_prok
synonym: "hydrogen/oligopeptide symporter" RELATED []
synonym: "proton-dependent oligopeptide transporter activity" EXACT []
is_a: GO:0015322 ! secondary active oligopeptide transmembrane transporter activity

[Term]
id: GO:0005429
name: chromaffin granule amine transmembrane transporter activity
namespace: molecular_function
is_a: GO:0005275 ! amine transmembrane transporter activity

[Term]
id: GO:0005430
name: synaptic vesicle amine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of amines across synaptic vesicle membranes." [GOC:ai]
is_a: GO:0005275 ! amine transmembrane transporter activity

[Term]
id: GO:0005432
name: calcium:sodium antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597]
subset: gosubset_prok
synonym: "mitochondrial sodium/calcium ion exchange" RELATED []
synonym: "sodium/calcium exchanger" EXACT []
synonym: "sodium:calcium exchange" RELATED []
is_a: GO:0015368 ! calcium:cation antiporter activity

[Term]
id: GO:0005436
name: sodium:phosphate symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [GOC:ai]
subset: gosubset_prok
synonym: "sodium/phosphate symporter activity" EXACT []
is_a: GO:0015114 ! phosphate transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0005451
name: monovalent cation:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out)." [GOC:ai]
subset: gosubset_prok
synonym: "monovalent cation:proton antiporter activity" EXACT [GOC:mah]
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015299 ! solute:hydrogen antiporter activity
is_a: GO:0015491 ! cation:cation antiporter activity

[Term]
id: GO:0005452
name: inorganic anion exchanger activity
namespace: molecular_function
is_a: GO:0015380 ! anion exchanger activity

[Term]
id: GO:0005456
name: CMP-sialic acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a CMP-sialic acid from one side of the membrane to the other. CMP-sialic acid is a substance composed of sialic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity

[Term]
id: GO:0005457
name: GDP-fucose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a GDP-fucose from one side of the membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity

[Term]
id: GO:0005458
name: GDP-mannose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a GDP-mannose from one side of the membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity

[Term]
id: GO:0005459
name: UDP-galactose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a UDP-galactose from one side of the membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity

[Term]
id: GO:0005460
name: UDP-glucose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a UDP-glucose from one side of the membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity

[Term]
id: GO:0005461
name: UDP-glucuronic acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a UDP-glucuronic acid from one side of the membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:15054 "UDP-glucuronic acid transmembrane transporter activity"
is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity

[Term]
id: GO:0005462
name: UDP-N-acetylglucosamine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a UDP-N-acetylglucosamine from one side of the membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity

[Term]
id: GO:0005463
name: UDP-N-acetylgalactosamine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a N-acetylgalactosamine from one side of the membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity

[Term]
id: GO:0005464
name: UDP-xylose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of UDP-xylose from one side of the membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai]
is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity

[Term]
id: GO:0005468
name: small-molecule carrier or transporter
namespace: molecular_function
alt_id: GO:0005453
alt_id: GO:0005454
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not provide a useful functional classification.
is_obsolete: true
consider: GO:0005215

[Term]
id: GO:0005469
name: succinate:fumarate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)." [TC:2.A.29.13.1]
is_a: GO:0015138 ! fumarate transmembrane transporter activity
is_a: GO:0015141 ! succinate transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0005471
name: ATP:ADP antiporter activity
namespace: molecular_function
alt_id: GO:0005349
def: "Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)." [TC:2.A.29.1.1]
subset: gosubset_prok
synonym: "adenine nucleotide translocase" EXACT []
synonym: "ADP/ATP translocase" EXACT []
synonym: "ATP/ADP exchange" EXACT []
synonym: "ATP/ADP exchanger" EXACT []
is_a: GO:0015300 ! solute:solute antiporter activity

[Term]
id: GO:0005472
name: FAD carrier activity
namespace: molecular_function
synonym: "flavin adenine dinucleotide carrier activity" EXACT []
synonym: "flavin-adenine dinucleotide carrier activity" EXACT []
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0005476
name: carnitine:acyl carnitine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial)." [PMID:9032458]
synonym: "carnitine/acyl carnitine carrier activity" EXACT []
synonym: "carnitine:acyl carnitine carrier activity" EXACT []
synonym: "fatty acyl carnitine carrier" EXACT []
is_a: GO:0015300 ! solute:solute antiporter activity

[Term]
id: GO:0005477
name: pyruvate secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
synonym: "pyruvate carrier activity" RELATED []
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0050833 ! pyruvate transmembrane transporter activity

[Term]
id: GO:0005479
name: vacuolar assembly
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a biological process and not a molecular function.
is_obsolete: true
replaced_by: GO:0007033

[Term]
id: GO:0005480
name: vesicle transport
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a biological process and not a molecular function.
is_obsolete: true
replaced_by: GO:0016192

[Term]
id: GO:0005481
name: vesicle fusion
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a biological process and not a molecular function.
is_obsolete: true
consider: GO:0006906
consider: GO:0007086
consider: GO:0016189
consider: GO:0016192
consider: GO:0019817

[Term]
id: GO:0005482
name: vesicle targeting
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a biological process and not a molecular function.
is_obsolete: true
consider: GO:0006903
consider: GO:0016080

[Term]
id: GO:0005483
name: soluble NSF attachment protein activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex." [GOC:mah, PMID:14570579, PMID:15556857]
synonym: "SNAP" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005484
name: SNAP receptor activity
namespace: molecular_function
alt_id: GO:0005485
alt_id: GO:0005486
def: "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]
synonym: "Q-SNARE activity" NARROW []
synonym: "R-SNARE activity" NARROW []
synonym: "SNAP-25" NARROW []
synonym: "SNARE" EXACT []
synonym: "t-SNARE activity" NARROW []
synonym: "v-SNARE activity" NARROW []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005487
name: nucleocytoplasmic transporter activity
namespace: molecular_function
def: "Enables the directed movement of substances between the nucleus and the cytoplasm of a cell." [GOC:ai]
is_a: GO:0005215 ! transporter activity

[Term]
id: GO:0005488
name: binding
namespace: molecular_function
def: "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children.
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "ligand" NARROW []
xref: Wikipedia:Binding_(molecular)
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0005489
name: electron transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of electrons into, out of, within or between cells." [GOC:ai]
comment: This term was made obsolete because the activity described by the definition does not exist.
synonym: "class I cytochrome c" RELATED []
synonym: "class II cytochrome c" RELATED []
synonym: "class IIa cytochrome c" RELATED []
synonym: "class IIb cytochrome c" RELATED []
synonym: "class III cytochrome c" RELATED []
synonym: "class IV cytochrome c" RELATED []
synonym: "cytochrome b" RELATED []
synonym: "cytochrome b5" RELATED []
synonym: "cytochrome c3 (tetraheme)" RELATED []
synonym: "cytochrome c554" RELATED []
synonym: "cytochrome c7 (triheme)" RELATED []
synonym: "cytochrome d" RELATED []
synonym: "diheme class I cytochrome c" RELATED []
synonym: "electron transfer carrier" RELATED []
synonym: "flavin-containing electron transporter" RELATED []
synonym: "flavodoxin" RELATED []
synonym: "high-molecular-weight cytochrome c (hexadecaheme)" RELATED []
synonym: "monoheme class I cytochrome c" RELATED []
synonym: "nonaheme cytochrome c" RELATED []
synonym: "respiratory chain cytochrome b6" RELATED []
synonym: "Rieske iron-sulfur protein" RELATED []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0005490
name: cytochrome P450
namespace: molecular_function
def: "OBSOLETE. A cytochrome b that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes:typically monooxygenases acting on lipophilic substrates." [ISBN:0198547684]
comment: This term was made obsolete because its definition was changed and because it represents a gene product.
is_obsolete: true

[Term]
id: GO:0005496
name: steroid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0005497
name: androgen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any androgen, male sex hormones." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0005496 ! steroid binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0005499
name: vitamin D binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [ChEBI:27300, GOC:mah, ISBN:0471331309]
synonym: "calciferol binding" NARROW []
synonym: "cholecalciferol binding" NARROW []
synonym: "ergocalciferol binding" NARROW []
is_a: GO:0005496 ! steroid binding
is_a: GO:0019842 ! vitamin binding

[Term]
id: GO:0005500
name: juvenile hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with juvenile hormone, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0019840 ! isoprenoid binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0005501
name: retinoid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0019840 ! isoprenoid binding

[Term]
id: GO:0005502
name: 11-cis retinal binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A." [http://cancerweb.ncl.ac.uk/]
synonym: "11-cis retinaldehyde binding" EXACT []
synonym: "vitamin A binding" BROAD []
is_a: GO:0016918 ! retinal binding

[Term]
id: GO:0005503
name: all-trans retinal binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A." [http://cancerweb.ncl.ac.uk/]
synonym: "all-trans retinaldehyde binding" EXACT []
synonym: "trans retinal binding" EXACT []
synonym: "visual yellow binding" EXACT []
synonym: "vitamin A binding" BROAD []
synonym: "xanthopsin" RELATED []
is_a: GO:0016918 ! retinal binding

[Term]
id: GO:0005504
name: fatty acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0008289 ! lipid binding
is_a: GO:0033293 ! monocarboxylic acid binding

[Term]
id: GO:0005505
name: heavy metal binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
is_obsolete: true
consider: GO:0046872

[Term]
id: GO:0005506
name: iron ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai]
subset: gosubset_prok
synonym: "iron binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0005507
name: copper ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai]
subset: gosubset_prok
synonym: "copper binding" EXACT []
synonym: "copper/cadmium binding" BROAD []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0005508
name: copper/cadmium binding
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a composite function.
is_obsolete: true
consider: GO:0005507
consider: GO:0046870

[Term]
id: GO:0005509
name: calcium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai]
subset: goslim_generic
subset: gosubset_prok
synonym: "calcium ion storage activity" RELATED []
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0005513
name: detection of calcium ion
namespace: biological_process
def: "The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal." [GOC:pg]
synonym: "Ca2+ ion detection" EXACT []
synonym: "calcium ion detection" EXACT []
synonym: "calcium ion sensing" EXACT []
synonym: "detection of Ca2+ ion" EXACT []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0051592 ! response to calcium ion

[Term]
id: GO:0005514
name: calcium ion storage activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
is_obsolete: true
replaced_by: GO:0005509
replaced_by: GO:0051208

[Term]
id: GO:0005515
name: protein binding
namespace: molecular_function
alt_id: GO:0045308
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "alpha-2 macroglobulin receptor-associated protein activity" RELATED []
synonym: "protein amino acid binding" EXACT []
synonym: "protein degradation tagging activity" RELATED []
synonym: "protein folding chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb]
synonym: "protein tagging activity" RELATED []
xref: Reactome:6125 "protein binding"
is_a: GO:0005488 ! binding

[Term]
id: GO:0005516
name: calmodulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]
subset: gosubset_prok
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005517
name: calmodulin inhibitor activity
namespace: molecular_function
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:tb]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'calmodulin activity'.
is_obsolete: true
consider: GO:0005516

[Term]
id: GO:0005518
name: collagen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005519
name: cytoskeletal regulatory protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein involved in modulating the reorganization of the cytoskeleton." [GOC:go_curators, PMID:15163540]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0005520
name: insulin-like growth factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "IGF binding" EXACT []
is_a: GO:0019838 ! growth factor binding

[Term]
id: GO:0005521
name: lamin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "lamin/chromatin binding" BROAD []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005522
name: profilin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0005523
name: tropomyosin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle." [http://cancerweb.ncl.ac.uk/]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0005524
name: ATP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: Reactome:1403 "ATP binding"
is_a: GO:0032559 ! adenyl ribonucleotide binding

[Term]
id: GO:0005525
name: GTP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai]
subset: gosubset_prok
xref: Reactome:12514 "GTP binding"
is_a: GO:0032561 ! guanyl ribonucleotide binding

[Term]
id: GO:0005527
name: macrolide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0008144 ! drug binding

[Term]
id: GO:0005528
name: FK506 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the immunosuppressant FK506." [GOC:jl]
synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" RELATED []
is_a: GO:0005527 ! macrolide binding

[Term]
id: GO:0005529
name: sugar binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0030246 ! carbohydrate binding

[Term]
id: GO:0005530
name: lectin
namespace: molecular_function
def: "OBSOLETE. Lectins are proteins obtained particularly from the seeds of leguminous plants, but also from many other plant and animal sources, that have binding sites for specific mono or oligosaccharides in cell walls or membranes. They thereby change the physiology of the membrane to cause agglutination, mitosis, or other biochemical changes in the cell." [http://cancerweb.ncl.ac.uk/]
comment: This term was made obsolete because it refers to a class of gene products.
is_obsolete: true
consider: GO:0005529
consider: GO:0007157

[Term]
id: GO:0005531
name: galactose binding lectin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
is_obsolete: true
consider: GO:0005534
consider: GO:0007157

[Term]
id: GO:0005532
name: mannose binding lectin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "mannose receptor" RELATED []
is_obsolete: true
consider: GO:0005537
consider: GO:0007157

[Term]
id: GO:0005533
name: N-acetylgalactosamine lectin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
is_obsolete: true
consider: GO:0007157
consider: GO:0046871

[Term]
id: GO:0005534
name: galactose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides." [ChEBI:28260, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "galactose binding lectin" RELATED []
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0005536
name: glucose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the D- or L-enantiomer of glucose." [ChEBI:17234, GOC:jl]
subset: gosubset_prok
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0005537
name: mannose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [ChEBI:37684, GOC:jl, ISBN:0192800981]
subset: gosubset_prok
synonym: "mannose binding lectin" RELATED []
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0005539
name: glycosaminoglycan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0005540
name: hyaluronic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine." [GOC:jl, http://cancerweb.ncl.ac.uk/]
synonym: "hyaluronan binding" EXACT []
is_a: GO:0005539 ! glycosaminoglycan binding

[Term]
id: GO:0005541
name: acyl-CoA or acyl binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with acyl-CoA or acyl, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group, or any group formally derived by removal of a hydroxyl group from the acid function of an organic acid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it was replaced by more appropriate terms.
is_obsolete: true
consider: GO:0000035
consider: GO:0000062

[Term]
id: GO:0005542
name: folic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "folate binding" EXACT []
synonym: "vitamin B9 binding" EXACT []
synonym: "vitamin M binding" EXACT []
is_a: GO:0016597 ! amino acid binding
is_a: GO:0019842 ! vitamin binding

[Term]
id: GO:0005543
name: phospholipid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0005544
name: calcium-dependent phospholipid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]
subset: gosubset_prok
is_a: GO:0005543 ! phospholipid binding

[Term]
id: GO:0005545
name: phosphatidylinositol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0035091 ! phosphoinositide binding

[Term]
id: GO:0005546
name: phosphatidylinositol-4,5-bisphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a diphosphorylated derivative of phosphatidylinositol." [GOC:bf, GOC:jl]
is_a: GO:0035091 ! phosphoinositide binding

[Term]
id: GO:0005547
name: phosphatidylinositol-3,4,5-trisphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, the triply phosphorylated derivative of phosphatidylinositol." [GOC:bf, GOC:jl]
is_a: GO:0035091 ! phosphoinositide binding

[Term]
id: GO:0005548
name: phospholipid transporter activity
namespace: molecular_function
alt_id: GO:0008497
def: "Enables the directed movement of phospholipids into, out of, within or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: Reactome:7040 "phospholipid transporter activity"
is_a: GO:0005319 ! lipid transporter activity

[Term]
id: GO:0005549
name: odorant binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0005550
name: pheromone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai]
is_a: GO:0005549 ! odorant binding

[Term]
id: GO:0005551
name: ubiquitin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0016567
consider: GO:0031386

[Term]
id: GO:0005552
name: polyubiquitin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
is_obsolete: true
consider: GO:0000209

[Term]
id: GO:0005553
name: ubiquitin-ribosomal protein fusion protein
namespace: molecular_function
def: "OBSOLETE. A protein encoded by some ubiquitin genes which consists of a single copy of ubiquitin fused to a ribosomal protein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it describes a gene product.
is_obsolete: true

[Term]
id: GO:0005555
name: blood group antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
is_obsolete: true

[Term]
id: GO:0005557
name: lymphocyte antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
is_obsolete: true

[Term]
id: GO:0005558
name: minor histocompatibility antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
is_obsolete: true

[Term]
id: GO:0005559
name: ribozyme
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005561
name: nucleic acid
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005562
name: RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005563
name: transfer RNA
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0030533

[Term]
id: GO:0005564
name: cytosolic tRNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005565
name: mitochondrial tRNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005566
name: ribosomal RNA
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0003735
consider: GO:0005840

[Term]
id: GO:0005567
name: cytosolic ribosomal RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005568
name: mitochondrial rRNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005569
name: small nucleolar RNA
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents gene products.
is_obsolete: true
consider: GO:0030555

[Term]
id: GO:0005570
name: small nuclear RNA
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents gene products.
is_obsolete: true
consider: GO:0000375
consider: GO:0017069

[Term]
id: GO:0005571
name: untranslated RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005572
name: RNA polymerase II transcribed untranslated RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005573
name: telomerase RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0000332

[Term]
id: GO:0005574
name: DNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused.
is_obsolete: true

[Term]
id: GO:0005575
name: cellular_component
namespace: cellular_component
alt_id: GO:0008372
def: "The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GOC:go_curators]
comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "cellular component" EXACT []
synonym: "cellular component unknown" NARROW []
xref: NIF_Subcellular:sao1337158144

[Term]
id: GO:0005576
name: extracellular region
namespace: cellular_component
def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]
comment: Note that this term is intended to annotate gene products that are not uniformly attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'.
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "extracellular" EXACT []
xref: Wikipedia:Extracellular
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005577
name: fibrinogen complex
namespace: cellular_component
def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684]
synonym: "fibrinogen" EXACT []
synonym: "fibrinogen alpha chain" NARROW []
synonym: "fibrinogen beta chain" NARROW []
synonym: "fibrinogen gamma chain" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005578
name: proteinaceous extracellular matrix
namespace: cellular_component
def: "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
is_a: GO:0031012 ! extracellular matrix

[Term]
id: GO:0005579
name: membrane attack complex
namespace: cellular_component
def: "A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow." [GOC:add, ISBN:0198547684, ISBN:068340007X "Stedman's Medical Dictionary", ISBN:0781735149 "Fundamental Immunology"]
synonym: "MAC" EXACT []
synonym: "membrane attack complex protein alphaM chain" NARROW []
synonym: "membrane attack complex protein beta2 chain" NARROW []
synonym: "TCC" EXACT []
synonym: "terminal complement complex" EXACT []
xref: Wikipedia:Complement_membrane_attack_complex
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0046930 ! pore complex
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005580
name: membrane attack complex protein alphaM chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005579

[Term]
id: GO:0005581
name: collagen
namespace: cellular_component
def: "Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures." [GOC:mah, ISBN:0721639976]
synonym: "other collagen" RELATED []
xref: Wikipedia:Collagen
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0005578 ! proteinaceous extracellular matrix

[Term]
id: GO:0005582
name: collagen type XV
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes." [PMID:11158616, PMID:11937714]
is_a: GO:0005581 ! collagen

[Term]
id: GO:0005583
name: fibrillar collagen
namespace: cellular_component
def: "Any collagen polymer in which collagen triple helices associate to form fibrils." [GOC:mah, ISBN:0721639976]
is_a: GO:0005581 ! collagen

[Term]
id: GO:0005584
name: collagen type I
namespace: cellular_component
def: "A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils." [GOC:mah, GOC:sl, ISBN:0721639976]
xref: Wikipedia:Collagen_type_I
is_a: GO:0005583 ! fibrillar collagen

[Term]
id: GO:0005585
name: collagen type II
namespace: cellular_component
def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976]
xref: Wikipedia:Collagen_type_II
is_a: GO:0005583 ! fibrillar collagen

[Term]
id: GO:0005586
name: collagen type III
namespace: cellular_component
def: "A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils." [ISBN:0721639976]
is_a: GO:0005583 ! fibrillar collagen

[Term]
id: GO:0005587
name: collagen type IV
namespace: cellular_component
def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form nets within basement membranes." [ISBN:0721639976]
xref: Wikipedia:Collagen_type_IV
is_a: GO:0030935 ! sheet-forming collagen
relationship: part_of GO:0005604 ! basement membrane

[Term]
id: GO:0005588
name: collagen type V
namespace: cellular_component
def: "A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils." [ISBN:0721639976]
is_a: GO:0005583 ! fibrillar collagen

[Term]
id: GO:0005589
name: collagen type VI
namespace: cellular_component
def: "A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils." [ISBN:0721639976]
is_a: GO:0030934 ! anchoring collagen

[Term]
id: GO:0005590
name: collagen type VII
namespace: cellular_component
def: "A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue." [ISBN:0721639976]
is_a: GO:0030934 ! anchoring collagen

[Term]
id: GO:0005591
name: collagen type VIII
namespace: cellular_component
def: "A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets." [ISBN:0721639976]
is_a: GO:0005598 ! short-chain collagen

[Term]
id: GO:0005592
name: collagen type XI
namespace: cellular_component
def: "A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils." [ISBN:0721639976]
is_a: GO:0005583 ! fibrillar collagen

[Term]
id: GO:0005593
name: FACIT collagen
namespace: cellular_component
def: "Any collagen polymer associated with collagen fibrils and in which the collagen monomers contain two or more relatively short triple-helical domains connected by non-triple-helical sequences; the acronym FACIT stands for fibril-associated collagen with interrupted triple helix." [ISBN:0198599587]
xref: Wikipedia:FACIT_collagen
is_a: GO:0030934 ! anchoring collagen

[Term]
id: GO:0005594
name: collagen type IX
namespace: cellular_component
def: "A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils." [ISBN:0721639976]
is_a: GO:0005593 ! FACIT collagen

[Term]
id: GO:0005595
name: collagen type XII
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976]
is_a: GO:0005593 ! FACIT collagen

[Term]
id: GO:0005596
name: collagen type XIV
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976]
is_a: GO:0005593 ! FACIT collagen

[Term]
id: GO:0005597
name: collagen type XVI
namespace: cellular_component
def: "A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils." [GOC:mah, PMID:12782140]
is_a: GO:0005593 ! FACIT collagen

[Term]
id: GO:0005598
name: short-chain collagen
namespace: cellular_component
def: "Any assembly of collagen in which the collagen chains are relatively short compared to the fibrillar collagens." [ISBN:0198599587]
is_a: GO:0030935 ! sheet-forming collagen

[Term]
id: GO:0005599
name: collagen type X
namespace: cellular_component
def: "A collagen homotrimer of alpha1(X) chains; type X collagen triple helices may form nets." [ISBN:0721639976]
is_a: GO:0005598 ! short-chain collagen

[Term]
id: GO:0005600
name: collagen type XIII
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XIII) chains; type X collagen triple helices span lipid bilayer membranes." [ISBN:0721639976]
is_a: GO:0030936 ! transmembrane collagen

[Term]
id: GO:0005601
name: classical-complement-pathway C3/C5 convertase complex
namespace: cellular_component
def: "A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone." [BRENDA:3.4.21.43, GOC:mah, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005602
name: complement component C1 complex
namespace: cellular_component
def: "A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "complement component C1q complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005603
name: complement component C2 complex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because prior to cleavage, complement component C2 is a single polypeptide rather than a complex, and after cleavage the products do not remain physically associated; there is thus no known biological entitiy corresponding to "complement C2 complex".
is_obsolete: true

[Term]
id: GO:0005604
name: basement membrane
namespace: cellular_component
def: "A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684]
xref: Wikipedia:Basement_membrane
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0005578 ! proteinaceous extracellular matrix

[Term]
id: GO:0005605
name: basal lamina
namespace: cellular_component
def: "A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix." [ISBN:0198547684]
synonym: "basement lamina" EXACT []
xref: NIF_Subcellular:sao1397492660
xref: Wikipedia:Basal_lamina
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0005604 ! basement membrane

[Term]
id: GO:0005606
name: laminin-1 complex
namespace: cellular_component
def: "A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005607
name: laminin-2 complex
namespace: cellular_component
def: "A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0005608
name: laminin-3 complex
namespace: cellular_component
def: "A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains." [MEDLINE:95005761]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005609
name: laminin-4 complex
namespace: cellular_component
def: "A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005610
name: laminin-5 complex
namespace: cellular_component
def: "A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005611
name: laminin-6 complex
namespace: cellular_component
def: "A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005612
name: laminin-7 complex
namespace: cellular_component
def: "A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0005613
name: laminin receptor protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is out of date. It seems to be referring to the non-integrin 34/67kDa laminin receptor, which new research has shown to actually be a ribosomal protein of the SP2 family.
is_obsolete: true
consider: GO:0008305

[Term]
id: GO:0005614
name: interstitial matrix
namespace: cellular_component
def: "A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens." [PMID:8450001]
is_a: GO:0005578 ! proteinaceous extracellular matrix

[Term]
id: GO:0005615
name: extracellular space
namespace: cellular_component
def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]
comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term.
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
synonym: "intercellular space" RELATED []
xref: NIF_Subcellular:sao1425028079
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0005616
name: larval serum protein complex
namespace: cellular_component
def: "A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins." [GOC:jl, PMID:6781759]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0005617
name: larval serum protein-1
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "LSP1" EXACT []
is_obsolete: true

[Term]
id: GO:0005618
name: cell wall
namespace: cellular_component
def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan." [ISBN:0198547684]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Cell_wall
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0005619
name: ascospore wall
namespace: cellular_component
def: "The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi." [GOC:vw, ISBN:0879693568]
synonym: "fungal-type spore wall" BROAD [GOC:mah]
is_a: GO:0009277 ! fungal-type cell wall
is_a: GO:0031160 ! spore wall

[Term]
id: GO:0005621
name: cellular bud scar
namespace: cellular_component
def: "Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age." [GOC:rn, PMID:14600225, PMID:2005820]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0005622
name: intracellular
namespace: cellular_component
def: "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "internal to cell" EXACT []
synonym: "nucleocytoplasm" RELATED [GOC:mah]
synonym: "protoplasm" EXACT []
synonym: "protoplast" RELATED [GOC:mah]
xref: Wikipedia:Intracellular
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005623
name: cell
namespace: cellular_component
def: "The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators]
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: gosubset_prok
xref: NIF_Subcellular:sao1813327414
xref: Wikipedia:Cell_(biology)
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0005624
name: membrane fraction
namespace: cellular_component
def: "That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes." [GOC:ma]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
subset: goslim_candida
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0005626 ! insoluble fraction

[Term]
id: GO:0005625
name: soluble fraction
namespace: cellular_component
def: "That fraction of cells, prepared by disruptive biochemical methods, that is soluble in water." [GOC:ma]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
synonym: "soluble" BROAD []
is_a: GO:0000267 ! cell fraction

[Term]
id: GO:0005626
name: insoluble fraction
namespace: cellular_component
def: "That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water." [GOC:ma]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
subset: gosubset_prok
synonym: "particle-bound" RELATED []
is_a: GO:0000267 ! cell fraction

[Term]
id: GO:0005627
name: ascus
namespace: cellular_component
def: "OBSOLETE. A sac-like fruiting body (ascomycete Fungi); contains ascospores (typically eight in number)." [ISBN:0198547684]
comment: This term was made obsolete because it is a type of cell rather than a cellular component. To update annotations, consider the external ontology term 'ascus ; FAO:0000014'.
is_obsolete: true

[Term]
id: GO:0005628
name: prospore membrane
namespace: cellular_component
def: "The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe." [ISBN:0879693649]
subset: gosubset_prok
synonym: "ascospore-type prospore membrane" EXACT [GOC:mah]
synonym: "forespore membrane" RELATED []
synonym: "FSM" EXACT []
is_a: GO:0016020 ! membrane
relationship: part_of GO:0042764 ! ascospore-type prospore

[Term]
id: GO:0005630
name: dityrosine layer of spore wall
namespace: cellular_component
def: "The outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0005619 ! ascospore wall

[Term]
id: GO:0005631
name: chitosan layer of spore wall
namespace: cellular_component
def: "The second outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0005619 ! ascospore wall

[Term]
id: GO:0005632
name: inner layer of spore wall
namespace: cellular_component
def: "Either of the two innermost layers of the spore wall, as described in Saccharomyces." [ISBN:0879693568]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0005619 ! ascospore wall

[Term]
id: GO:0005633
name: ascus lipid particle
namespace: cellular_component
def: "Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins." [GOC:mah, PMID:12702293]
synonym: "ascus lipid droplet" EXACT [GOC:curators]
is_a: GO:0005811 ! lipid particle

[Term]
id: GO:0005634
name: nucleus
namespace: cellular_component
def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "cell nucleus" EXACT []
xref: NIF_Subcellular:sao1702920020
xref: Wikipedia:Cell_nucleus
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0005635
name: nuclear envelope
namespace: cellular_component
alt_id: GO:0005636
def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]
subset: goslim_generic
subset: goslim_plant
xref: Wikipedia:Nuclear_envelope
is_a: GO:0031967 ! organelle envelope
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0005637
name: nuclear inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma]
synonym: "inner envelope" BROAD []
xref: NIF_Subcellular:sao1612527463
is_a: GO:0019866 ! organelle inner membrane
is_a: GO:0031965 ! nuclear membrane

[Term]
id: GO:0005638
name: lamin filament
namespace: cellular_component
def: "Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C." [ISBN:0198547684]
synonym: "type V intermediate filament" EXACT []
is_a: GO:0005882 ! intermediate filament
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005652 ! nuclear lamina

[Term]
id: GO:0005639
name: integral to nuclear inner membrane
namespace: cellular_component
def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the nuclear inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators]
is_a: GO:0031229 ! intrinsic to nuclear inner membrane
is_a: GO:0031301 ! integral to organelle membrane

[Term]
id: GO:0005640
name: nuclear outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684]
synonym: "outer envelope" BROAD []
synonym: "perinuclear membrane" EXACT []
xref: NIF_Subcellular:sao1617136075
is_a: GO:0031965 ! nuclear membrane
is_a: GO:0031968 ! organelle outer membrane
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0042175 ! nuclear envelope-endoplasmic reticulum network

[Term]
id: GO:0005641
name: nuclear envelope lumen
namespace: cellular_component
alt_id: GO:0005653
def: "The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide." [GOC:ai]
comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'.
synonym: "nuclear intermembrane space" EXACT []
synonym: "nuclear membrane lumen" RELATED []
synonym: "perinuclear space" EXACT []
is_a: GO:0031970 ! organelle envelope lumen
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0005642
name: annulate lamellae
namespace: cellular_component
def: "Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER." [PMID:12631728]
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0042175 ! nuclear envelope-endoplasmic reticulum network

[Term]
id: GO:0005643
name: nuclear pore
namespace: cellular_component
alt_id: GO:0005644
def: "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]
subset: goslim_pir
synonym: "NPC" EXACT []
synonym: "nuclear pore complex" EXACT []
synonym: "nuclear pore membrane protein" NARROW []
xref: NIF_Subcellular:sao220861693
xref: Wikipedia:Nuclear_pore
is_a: GO:0044428 ! nuclear part
is_a: GO:0046930 ! pore complex
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0005645
name: RAN-binding protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0008536
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737

[Term]
id: GO:0005646
name: importin
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "karyopherin" EXACT []
is_obsolete: true
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737

[Term]
id: GO:0005647
name: importin, alpha-subunit
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "karyopherin-alpha" EXACT []
is_obsolete: true
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737

[Term]
id: GO:0005648
name: importin, beta-subunit
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "karyopherin-beta1" EXACT []
is_obsolete: true
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737

[Term]
id: GO:0005649
name: transportin
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "karyopherin-beta2" EXACT []
is_obsolete: true
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737

[Term]
id: GO:0005650
name: importin, alpha-subunit transport factor
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
synonym: "CAS" RELATED []
is_obsolete: true
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737

[Term]
id: GO:0005651
name: exportin
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
consider: GO:0005634
consider: GO:0005643
consider: GO:0005737

[Term]
id: GO:0005652
name: nuclear lamina
namespace: cellular_component
def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363]
xref: NIF_Subcellular:sao1455996588
xref: Wikipedia:Nuclear_lamina
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005637 ! nuclear inner membrane
relationship: part_of GO:0034399 ! nuclear periphery

[Term]
id: GO:0005654
name: nucleoplasm
namespace: cellular_component
def: "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]
subset: goslim_generic
subset: goslim_plant
xref: NIF_Subcellular:sao661522542
xref: Wikipedia:Nucleoplasm
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0005655
name: nucleolar ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094]
synonym: "nucleolar RNase P complex" EXACT []
is_a: GO:0030681 ! multimeric ribonuclease P complex
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0005656
name: pre-replicative complex
namespace: cellular_component
def: "A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins." [PMID:15222894]
synonym: "pre-RC" EXACT []
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0005657
name: replication fork
namespace: cellular_component
def: "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "replication focus" RELATED []
xref: Wikipedia:Replication_fork
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0005658
name: alpha DNA polymerase:primase complex
namespace: cellular_component
def: "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402]
synonym: "DNA polymerase alpha:primase complex" EXACT []
synonym: "heterotetrameric polymerase alpha holoenzyme" EXACT []
synonym: "pol-prim" RELATED []
synonym: "primosome" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043601 ! nuclear replisome

[Term]
id: GO:0005660
name: delta-DNA polymerase cofactor complex
namespace: cellular_component
def: "OBSOLETE. A complex of proteins that interacts with delta-DNA polymerase, promoting elongation. In humans it is a heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa, which form a complex with the proliferating cell nuclear antigen (PCNA) in the presence of ATP." [GOC:jl]
comment: This term was made obsolete because it refers to two distinct complexes, PCNA and Replication factor C (RFC), the latter of which is already represented as a separate, unrelated GO term (DNA replication factor C complex ; GO:0005663). In addition, the phrase 'delta-DNA polymerase cofactor' to represent both PCNA and RFC is not used in current literature.
synonym: "delta DNA polymerase cofactor complex" EXACT []
is_obsolete: true
replaced_by: GO:0005663
replaced_by: GO:0043626

[Term]
id: GO:0005662
name: DNA replication factor A complex
namespace: cellular_component
def: "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902]
synonym: "replication protein A" EXACT []
synonym: "RPA" EXACT []
synonym: "single-stranded DNA-binding protein complex" RELATED []
synonym: "SSB" RELATED []
xref: Wikipedia:Replication_protein_A
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043601 ! nuclear replisome

[Term]
id: GO:0005663
name: DNA replication factor C complex
namespace: cellular_component
def: "A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase." [PMID:14614842, PMID:14646196, PMID:16172520]
subset: goslim_pir
subset: gosubset_prok
synonym: "activator 1 complex" EXACT []
synonym: "RFC complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005657 ! replication fork

[Term]
id: GO:0005664
name: nuclear origin of replication recognition complex
namespace: cellular_component
def: "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh]
synonym: "eukaryotic ORC" EXACT []
synonym: "nuclear ORC" EXACT []
is_a: GO:0000808 ! origin recognition complex
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0005665
name: DNA-directed RNA polymerase II, core complex
namespace: cellular_component
def: "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
synonym: "RNA polymerase II complex" BROAD []
synonym: "RNAP II complex" BROAD []
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005666
name: DNA-directed RNA polymerase III complex
namespace: cellular_component
def: "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
synonym: "DNA-directed RNA polymerase III activity" RELATED []
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex

[Term]
id: GO:0005667
name: transcription factor complex
namespace: cellular_component
def: "A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription." [GOC:mah]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0005668
name: RNA polymerase transcription factor SL1 complex
namespace: cellular_component
def: "A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48." [PMID:15691654]
synonym: "selectivity factor SL1 complex" EXACT [GOC:mah]
synonym: "TIF-IB" EXACT [CORUM:480, PMID:15691654]
is_a: GO:0000120 ! RNA polymerase I transcription factor complex

[Term]
id: GO:0005669
name: transcription factor TFIID complex
namespace: cellular_component
def: "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]
is_a: GO:0005667 ! transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005670
name: transcription-activating factor, 30kD
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005669

[Term]
id: GO:0005671
name: Ada2/Gcn5/Ada3 transcription activator complex
namespace: cellular_component
def: "A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [PMID:10637607]
is_a: GO:0000123 ! histone acetyltransferase complex

[Term]
id: GO:0005672
name: transcription factor TFIIA complex
namespace: cellular_component
def: "A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12)." [GOC:jl, PMID:17560669]
is_a: GO:0005667 ! transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005673
name: transcription factor TFIIE complex
namespace: cellular_component
def: "A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH." [GOC:jl, PMID:16547462]
is_a: GO:0005667 ! transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005674
name: transcription factor TFIIF complex
namespace: cellular_component
def: "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077]
is_a: GO:0005667 ! transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005675
name: holo TFIIH complex
namespace: cellular_component
def: "A complex that contains kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. In S. cerevisiae, it is composed of the 5-subunit core (Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p), Ssl2p, and TFIIK (Kin28p, Ccl1p, and Tfb3p). All of the subunits have equivalents in humans: the 5 subunit core is composed of ERCC2, p62, p55, p44, p34; the equivalent of the TFIIK subcomplex is composed of MO15, Mat1, and a cyclin; the human equivalent of Ssl2p is XPB." [GOC:krc, PMID:14500720, PMID:7813015]
is_a: GO:0005667 ! transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0005677
name: chromatin silencing complex
namespace: cellular_component
def: "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah]
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0005678
name: chromatin assembly complex
namespace: cellular_component
def: "Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure." [GOC:mah]
synonym: "nucleosome assembly complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0005680
name: anaphase-promoting complex
namespace: cellular_component
def: "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, PMID:10465783, PMID:10611969]
comment: Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein.
synonym: "anaphase promoting complex" EXACT []
synonym: "APC" BROAD []
synonym: "cyclosome" EXACT []
xref: Wikipedia:Anaphase-promoting_complex
is_a: GO:0000152 ! nuclear ubiquitin ligase complex

[Term]
id: GO:0005681
name: spliceosomal complex
namespace: cellular_component
def: "Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron." [GOC:mah, ISBN:0198547684, PMID:19239890]
subset: goslim_pir
synonym: "spliceosome complex" EXACT []
xref: Wikipedia:Spliceosome
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0005682
name: U5 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U5." [GOC:krc, GOC:mah]
synonym: "snRNP U5" EXACT [GOC:mah]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0005683
name: U7 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs." [PMID:12872004]
synonym: "snRNP U7" EXACT [GOC:mah]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0005684
name: U2-type spliceosomal complex
namespace: cellular_component
def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends." [GOC:krc, GOC:mah, PMID:11343900]
synonym: "GT-AG spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "major (U2-type) spliceosomal complex" EXACT [GOC:krc, GOC:mah]
synonym: "major spliceosomal complex" EXACT [GOC:krc, GOC:mah]
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0005685
name: U1 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U1." [GOC:krc, GOC:mah]
synonym: "snRNP U1" EXACT [GOC:mah]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0005686
name: U2 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U2." [GOC:krc, GOC:mah]
synonym: "17S U2 snRNP" NARROW []
synonym: "snRNP U2" EXACT [GOC:mah]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0005687
name: U4 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U4." [GOC:krc, GOC:mah]
synonym: "snRNP U4" EXACT [GOC:mah]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0005688
name: U6 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U6." [GOC:krc, GOC:mah]
synonym: "snRNP U6" EXACT [GOC:mah]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0005689
name: U12-type spliceosomal complex
namespace: cellular_component
def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955]
synonym: "AT-AC spliceosomal complex" NARROW [GOC:krc, GOC:mah]
synonym: "minor (U12-type) spliceosomal complex" EXACT [GOC:mah]
synonym: "minor spliceosomal complex" EXACT [GOC:krc, GOC:mah]
xref: Wikipedia:Minor_spliceosome
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0005690
name: U4atac snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U4atac." [GOC:krc, GOC:mah]
synonym: "snRNP U4atac" EXACT [GOC:mah]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0005691
name: U6atac snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U6atac." [GOC:krc, GOC:mah]
synonym: "snRNP U6atac" EXACT [GOC:mah]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0005692
name: U11 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U11." [GOC:krc, GOC:mah]
synonym: "12S U11 snRNP" NARROW []
synonym: "snRNP U11" EXACT [GOC:mah]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0005693
name: U12 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains small nuclear RNA U12." [GOC:krc, GOC:mah]
synonym: "snRNP U12" EXACT [GOC:mah]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0005694
name: chromosome
namespace: cellular_component
def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "chromatid" RELATED []
synonym: "interphase chromosome" NARROW []
synonym: "prophase chromosome" NARROW []
xref: Wikipedia:Chromosome
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0005695
name: chromatid
namespace: cellular_component
def: "OBSOLETE. One of the two daughter strands of a duplicated chromosome that become apparent between early prophase and metaphase in mitosis and between diplotene and second metaphase in meiosis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it is not a unique subcellular component, i.e. the difference between this term and 'chromosome' is based on temporal and process distinctions.
is_obsolete: true
consider: GO:0000793
consider: GO:0000794
consider: GO:0005694

[Term]
id: GO:0005696
name: telomere
namespace: cellular_component
def: "OBSOLETE. A complex of DNA and protein that seals the end of a chromosome. The telomeric DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11352055]
comment: This term was made obsolete because the definition was too sequence oriented and too restrictive.
is_obsolete: true
consider: GO:0000781
consider: GO:0000782

[Term]
id: GO:0005697
name: telomerase holoenzyme complex
namespace: cellular_component
def: "Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits." [PMID:11884619]
subset: goslim_pir
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0005698
name: centromere
namespace: cellular_component
def: "OBSOLETE. The region of a eukaryotic chromosome that is attached to the spindle during nuclear division. It is defined genetically as the region of the chromosome that always segregates at the first division of meiosis; the region of the chromosome in which no crossing over occurs. At the start of M phase, each chromosome consists of two sister chromatids with a constriction at a point which forms the centromere. During late prophase two kinetochores assemble on each centromere, one kinetochore on each sister chromatid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it is a genetically defined region and not a specific subcellular localization.
is_obsolete: true
consider: GO:0000775

[Term]
id: GO:0005700
name: polytene chromosome
namespace: cellular_component
def: "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: Wikipedia:Polytene_chromosome
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0005701
name: polytene chromosome chromocenter
namespace: cellular_component
def: "A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012]
synonym: "polytene chromosome chromocentre" EXACT []
is_a: GO:0010369 ! chromocenter
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005702
name: polytene chromosome weak point
namespace: cellular_component
def: "A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization." [GOC:bf, ISBN:0120649012]
synonym: "constriction" BROAD []
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005703
name: polytene chromosome puff
namespace: cellular_component
def: "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005704
name: polytene chromosome band
namespace: cellular_component
def: "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342]
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005705
name: polytene chromosome interband
namespace: cellular_component
def: "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005706
name: polytene chromosome ectopic fiber
namespace: cellular_component
def: "A thread-like connection joining two regions of ectopically paired polytene chromosomes." [GOC:bf, ISBN:0120649012]
synonym: "polytene chromosome ectopic fibre" EXACT []
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0005707
name: interphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cell during interphase of the cell cycle. Chromosomes are usually decondensed during interphase and each long DNA molecule in a chromosome is divided into a large number of discrete domains that are folded differently." [GOC:ai, ISBN:0815316194]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
is_obsolete: true
consider: GO:0005694

[Term]
id: GO:0005708
name: mitotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome involved in the process of mitosis." [GOC:ai]
comment: This term was made obsolete because it is based on a process.
is_obsolete: true
consider: GO:0000793
consider: GO:0000794

[Term]
id: GO:0005709
name: prophase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cell during prophase." [GOC:ai]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
is_obsolete: true
consider: GO:0005694

[Term]
id: GO:0005710
name: metaphase chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome found in the cell during metaphase. Typically, sister chromatids are held together at their centromeres and chromosomes are covered with a large number of molecules, including ribonucleoproteins." [GOC:ai]
comment: This term was made obsolete because it is based on a temporal division of the cell cycle.
is_obsolete: true
consider: GO:0000793
consider: GO:0000794

[Term]
id: GO:0005711
name: meiotic chromosome
namespace: cellular_component
def: "OBSOLETE. A chromosome involved in the process of meiosis." [GOC:ai]
comment: This term was made obsolete because it is based on a process.
is_obsolete: true
consider: GO:0000794

[Term]
id: GO:0005712
name: chiasma
namespace: cellular_component
def: "A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: Wikipedia:Chiasma_(genetics)
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0005713
name: recombination nodule
namespace: cellular_component
def: "An electron dense structure that is associated with meiotic chromosomes." [GOC:elh]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0005714
name: early recombination nodule
namespace: cellular_component
def: "An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I." [GOC:elh]
is_a: GO:0005713 ! recombination nodule

[Term]
id: GO:0005715
name: late recombination nodule
namespace: cellular_component
def: "An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I." [GOC:elh]
is_a: GO:0005713 ! recombination nodule

[Term]
id: GO:0005719
name: nuclear euchromatin
namespace: cellular_component
def: "The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0000790 ! nuclear chromatin
is_a: GO:0000791 ! euchromatin

[Term]
id: GO:0005720
name: nuclear heterochromatin
namespace: cellular_component
def: "A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0000790 ! nuclear chromatin
is_a: GO:0000792 ! heterochromatin

[Term]
id: GO:0005721
name: centromeric heterochromatin
namespace: cellular_component
def: "A region of heterochromatin located near the centromere of a chromosome." [PMID:12019236]
synonym: "centric heterochromatin" EXACT []
is_a: GO:0000792 ! heterochromatin
relationship: part_of GO:0000775 ! chromosome, centromeric region

[Term]
id: GO:0005722
name: beta-heterochromatin
namespace: cellular_component
def: "A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization." [PMID:11404334, PMID:8878678]
is_a: GO:0005721 ! centromeric heterochromatin
relationship: part_of GO:0005701 ! polytene chromosome chromocenter

[Term]
id: GO:0005723
name: alpha-heterochromatin
namespace: cellular_component
def: "A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization." [PMID:8878678]
is_a: GO:0005721 ! centromeric heterochromatin
relationship: part_of GO:0005701 ! polytene chromosome chromocenter

[Term]
id: GO:0005724
name: nuclear telomeric heterochromatin
namespace: cellular_component
def: "Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus." [GOC:ai]
is_a: GO:0005720 ! nuclear heterochromatin
is_a: GO:0031933 ! telomeric heterochromatin
relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region

[Term]
id: GO:0005725
name: intercalary heterochromatin
namespace: cellular_component
def: "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245]
is_a: GO:0005720 ! nuclear heterochromatin

[Term]
id: GO:0005726
name: perichromatin fibrils
namespace: cellular_component
def: "Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts." [PMID:14731598]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0005727
name: extrachromosomal circular DNA
namespace: cellular_component
def: "Circular DNA structures that are not part of a chromosome." [GOC:ai]
subset: gosubset_prok
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0046821 ! extrachromosomal DNA

[Term]
id: GO:0005728
name: extrachromosomal rDNA circle
namespace: cellular_component
def: "Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats." [GOC:mah, PMID:12044934]
synonym: "extrachromosomal ribosomal DNA circle" EXACT []
is_a: GO:0005727 ! extrachromosomal circular DNA

[Term]
id: GO:0005729
name: 2-micrometer circle DNA
namespace: cellular_component
def: "A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies." [PMID:12073320]
is_a: GO:0005727 ! extrachromosomal circular DNA

[Term]
id: GO:0005730
name: nucleolus
namespace: cellular_component
def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
xref: NIF_Subcellular:sao1820400233
xref: Wikipedia:Nucleolus
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0005731
name: nucleolus organizer region
namespace: cellular_component
def: "A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed." [PMID:14504406]
synonym: "NOR" EXACT []
synonym: "nucleolus organiser region" EXACT []
synonym: "nucleolus organizer complex" RELATED []
xref: Wikipedia:Nucleolus_organizer_region
is_a: GO:0030874 ! nucleolar chromatin
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0005732
name: small nucleolar ribonucleoprotein complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains a small nucleolar RNA (snoRNA) and associated proteins, and is found in eukaryotic cells. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type." [GOC:krc, GOC:mah, ISBN:0879695897]
subset: goslim_pir
synonym: "small nucleolar ribonucleoprotein" EXACT []
synonym: "snoRNP" EXACT []
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0005733
name: small nucleolar RNA
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "snoRNA" EXACT []
is_obsolete: true

[Term]
id: GO:0005734
name: box C + D snoRNP protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true

[Term]
id: GO:0005735
name: box H + ACA snoRNP protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true

[Term]
id: GO:0005736
name: DNA-directed RNA polymerase I complex
namespace: cellular_component
def: "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]
synonym: "DNA-directed RNA polymerase I activity" RELATED []
is_a: GO:0044452 ! nucleolar part
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex

[Term]
id: GO:0005737
name: cytoplasm
namespace: cellular_component
def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Cytoplasm
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005739
name: mitochondrion
namespace: cellular_component
def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "mitochondria" EXACT []
xref: NIF_Subcellular:sao1860313010
xref: Wikipedia:Mitochondrion
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005740
name: mitochondrial envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]
subset: goslim_candida
subset: goslim_yeast
is_a: GO:0031967 ! organelle envelope
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0005741
name: mitochondrial outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai]
synonym: "outer mitochondrial membrane" EXACT []
xref: NIF_Subcellular:sao1289741256
xref: Wikipedia:Outer_mitochondrial_membrane
is_a: GO:0031966 ! mitochondrial membrane
is_a: GO:0031968 ! organelle outer membrane

[Term]
id: GO:0005742
name: mitochondrial outer membrane translocase complex
namespace: cellular_component
def: "A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629]
synonym: "GIP complex" NARROW []
synonym: "TOM complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005741 ! mitochondrial outer membrane

[Term]
id: GO:0005743
name: mitochondrial inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]
synonym: "inner mitochondrial membrane" EXACT []
xref: NIF_Subcellular:sao1371347282
xref: Wikipedia:Inner_mitochondrial_membrane
is_a: GO:0019866 ! organelle inner membrane
is_a: GO:0031966 ! mitochondrial membrane

[Term]
id: GO:0005744
name: mitochondrial inner membrane presequence translocase complex
namespace: cellular_component
def: "The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:3.6.3.51, PMID:8851659]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
subset: goslim_pir
synonym: "mitochondrial inner membrane pre-sequence translocase complex" EXACT []
synonym: "mitochondrial inner membrane translocase complex" EXACT []
synonym: "Tim23 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0005745
name: m-AAA complex
namespace: cellular_component
def: "Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria." [PMID:12417197]
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0005746
name: mitochondrial respiratory chain
namespace: cellular_component
def: "The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684]
synonym: "mitochondrial electron transport chain" EXACT []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0070469 ! respiratory chain
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0005747
name: mitochondrial respiratory chain complex I
namespace: cellular_component
alt_id: GO:0005748
def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045271 ! respiratory chain complex I
relationship: part_of GO:0005746 ! mitochondrial respiratory chain

[Term]
id: GO:0005749
name: mitochondrial respiratory chain complex II
namespace: cellular_component
alt_id: GO:0008136
alt_id: GO:0009362
alt_id: GO:0019738
alt_id: GO:0030390
def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [GOC:mtg_sensu, ISBN:0198547684]
synonym: "mitochondrial fumarate reductase complex" EXACT []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045257 ! succinate dehydrogenase complex (ubiquinone)
is_a: GO:0045283 ! fumarate reductase complex
relationship: part_of GO:0005746 ! mitochondrial respiratory chain

[Term]
id: GO:0005750
name: mitochondrial respiratory chain complex III
namespace: cellular_component
alt_id: GO:0015008
def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684]
synonym: "mitochondrial complex III" EXACT [GOC:mcc]
synonym: "mitochondrial cytochrome bc(1) complex" EXACT [GOC:mcc]
synonym: "mitochondrial cytochrome bc1 complex" EXACT [GOC:mcc]
synonym: "mitochondrial electron transport complex III" RELATED [GOC:mcc]
synonym: "mitochondrial ubiquinol-cytochrome c oxidoreductase complex" EXACT [GOC:mcc]
synonym: "mitochondrial ubiquinol-cytochrome-c reductase complex" EXACT [GOC:mcc]
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045275 ! respiratory chain complex III
relationship: part_of GO:0005746 ! mitochondrial respiratory chain

[Term]
id: GO:0005751
name: mitochondrial respiratory chain complex IV
namespace: cellular_component
alt_id: GO:0005752
def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045277 ! respiratory chain complex IV
relationship: part_of GO:0005746 ! mitochondrial respiratory chain

[Term]
id: GO:0005753
name: mitochondrial proton-transporting ATP synthase complex
namespace: cellular_component
alt_id: GO:0016470
def: "A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu]
synonym: "mitochondrial respiratory chain complex V" EXACT []
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045259 ! proton-transporting ATP synthase complex
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0005754
name: mitochondrial proton-transporting ATP synthase, catalytic core
namespace: cellular_component
def: "The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [GOC:mtg_sensu, PMID:10838056]
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045267 ! proton-transporting ATP synthase, catalytic core
relationship: part_of GO:0000275 ! mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)

[Term]
id: GO:0005755
name: hydrogen-transporting ATP synthase, coupling factor CF(0)
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
is_obsolete: true
consider: GO:0045263

[Term]
id: GO:0005756
name: mitochondrial proton-transporting ATP synthase, central stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis." [GOC:mtg_sensu, PMID:10838056]
is_a: GO:0044455 ! mitochondrial membrane part
is_a: GO:0045269 ! proton-transporting ATP synthase, central stalk
relationship: part_of GO:0000275 ! mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)

[Term]
id: GO:0005757
name: mitochondrial permeability transition pore complex
namespace: cellular_component
def: "A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol." [PMID:10393078]
synonym: "mitochondrial PT pore complex" EXACT []
is_a: GO:0044429 ! mitochondrial part
is_a: GO:0046930 ! pore complex
relationship: part_of GO:0005740 ! mitochondrial envelope

[Term]
id: GO:0005758
name: mitochondrial intermembrane space
namespace: cellular_component
alt_id: GO:0031971
def: "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah]
synonym: "mitochondrial envelope lumen" EXACT []
synonym: "mitochondrial membrane lumen" RELATED []
xref: NIF_Subcellular:sao118944228
is_a: GO:0031970 ! organelle envelope lumen
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005740 ! mitochondrial envelope

[Term]
id: GO:0005759
name: mitochondrial matrix
namespace: cellular_component
def: "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty-acid oxidation." [GOC:as, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "mitochondrial stroma" NARROW []
xref: NIF_Subcellular:sao1804523077
xref: Wikipedia:Mitochondrial_matrix
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0031980 ! mitochondrial lumen

[Term]
id: GO:0005760
name: gamma DNA polymerase complex
namespace: cellular_component
def: "A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA." [GOC:jl, PMID:12045093]
is_a: GO:0042575 ! DNA polymerase complex
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0005761
name: mitochondrial ribosome
namespace: cellular_component
def: "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "55S ribosome, mitochondrial" NARROW []
is_a: GO:0000313 ! organellar ribosome
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0005762
name: mitochondrial large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]
synonym: "39S ribosomal subunit, mitochondrial" NARROW []
is_a: GO:0000315 ! organellar large ribosomal subunit
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005761 ! mitochondrial ribosome

[Term]
id: GO:0005763
name: mitochondrial small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc]
synonym: "28S ribosomal subunit, mitochondrial" NARROW []
synonym: "mitochondrial ribosomal small subunit complex" EXACT []
synonym: "mitochondrial ribosomal SSU complex" EXACT []
is_a: GO:0000314 ! organellar small ribosomal subunit
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005761 ! mitochondrial ribosome

[Term]
id: GO:0005764
name: lysosome
namespace: cellular_component
def: "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_generic
subset: goslim_plant
xref: NIF_Subcellular:sao585356902
xref: Wikipedia:Lysosome
is_a: GO:0000323 ! lytic vacuole

[Term]
id: GO:0005765
name: lysosomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]
is_a: GO:0005774 ! vacuolar membrane
relationship: part_of GO:0005764 ! lysosome

[Term]
id: GO:0005766
name: primary lysosome
namespace: cellular_component
def: "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, http://cancerweb.ncl.ac.uk/]
xref: NIF_Subcellular:sao1140587416
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0005767
name: secondary lysosome
namespace: cellular_component
def: "Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome." [GOC:jl, http://cancerweb.ncl.ac.uk/]
xref: NIF_Subcellular:sao1549842807
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0005768
name: endosome
namespace: cellular_component
def: "A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
xref: NIF_Subcellular:sao1720343330
xref: Wikipedia:Endosome
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005769
name: early endosome
namespace: cellular_component
def: "Small irregularly shaped intracellular vesicles to which endocytosed molecules are initially delivered." [GOC:rb]
is_a: GO:0005768 ! endosome

[Term]
id: GO:0005770
name: late endosome
namespace: cellular_component
def: "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [PMID:11964142, PMID:2557062]
synonym: "prevacuolar compartment" EXACT []
synonym: "PVC" BROAD []
is_a: GO:0005768 ! endosome

[Term]
id: GO:0005771
name: multivesicular body
namespace: cellular_component
def: "A type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881]
synonym: "multivesicular endosome" EXACT [PMID:12122203]
synonym: "MVB" EXACT []
synonym: "MVE" EXACT [PMID:12122203]
xref: NIF_Subcellular:sao2045955158
is_a: GO:0005770 ! late endosome

[Term]
id: GO:0005773
name: vacuole
namespace: cellular_component
def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "vacuolar carboxypeptidase Y" RELATED []
xref: Wikipedia:Vacuole
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005774
name: vacuolar membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai]
subset: gosubset_prok
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044437 ! vacuolar part

[Term]
id: GO:0005775
name: vacuolar lumen
namespace: cellular_component
def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0044437 ! vacuolar part
is_a: GO:0070013 ! intracellular organelle lumen

[Term]
id: GO:0005776
name: autophagic vacuole
namespace: cellular_component
def: "A double-membrane-bounded compartment in which endogenous cellular material is sequestered; known as autophagosome in yeast." [ISBN:0198547684, PMID:11099404]
synonym: "autophagosome" EXACT []
is_a: GO:0005773 ! vacuole

[Term]
id: GO:0005777
name: peroxisome
namespace: cellular_component
alt_id: GO:0019818
def: "A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [ISBN:0815316194]
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
synonym: "peroxisome vesicle" BROAD []
xref: NIF_Subcellular:sao499555322
xref: Wikipedia:Peroxisome
is_a: GO:0042579 ! microbody

[Term]
id: GO:0005778
name: peroxisomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a peroxisome." [GOC:mah]
synonym: "peroxisome membrane" EXACT []
is_a: GO:0031903 ! microbody membrane
is_a: GO:0044439 ! peroxisomal part

[Term]
id: GO:0005779
name: integral to peroxisomal membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a peroxisomal membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031231 ! intrinsic to peroxisomal membrane
is_a: GO:0031301 ! integral to organelle membrane

[Term]
id: GO:0005780
name: extrinsic to intraperoxisomal membrane
namespace: cellular_component
def: "Loosely bound to the intraperoxisomal surface of the peroxisomal membrane, but not integrated into the hydrophobic region." [GOC:mah]
synonym: "intra-peroxisomal peripheral membrane" RELATED []
is_a: GO:0031312 ! extrinsic to organelle membrane
is_a: GO:0044439 ! peroxisomal part
relationship: part_of GO:0005778 ! peroxisomal membrane

[Term]
id: GO:0005781
name: peroxisome targeting signal receptor complex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a single polypeptide rather than a complex; all known peroxisome targeting signal receptors are monomeric.
is_obsolete: true
consider: GO:0000268
consider: GO:0006625
consider: GO:0044439

[Term]
id: GO:0005782
name: peroxisomal matrix
namespace: cellular_component
alt_id: GO:0031909
def: "The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase." [GOC:curators, ISBN:0815316194]
synonym: "peroxisomal lumen" EXACT []
is_a: GO:0031907 ! microbody lumen
is_a: GO:0044439 ! peroxisomal part

[Term]
id: GO:0005783
name: endoplasmic reticulum
namespace: cellular_component
def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "ER" EXACT []
xref: NIF_Subcellular:sao1036339110
xref: Wikipedia:Endoplasmic_reticulum
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005784
name: Sec61 translocon complex
namespace: cellular_component
def: "A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events." [GOC:mah, PMID:18166647]
subset: goslim_pir
synonym: "Sec61p-Sbh1p-Sss1p complex" NARROW [GOC:mah]
is_a: GO:0071256 ! translocon complex

[Term]
id: GO:0005785
name: signal recognition particle receptor complex
namespace: cellular_component
def: "A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "docking protein complex" RELATED []
synonym: "SR complex" EXACT []
is_a: GO:0043235 ! receptor complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane

[Term]
id: GO:0005786
name: signal recognition particle, endoplasmic reticulum targeting
namespace: cellular_component
alt_id: GO:0005855
def: "A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "signal sequence receptor complex" EXACT []
synonym: "SRP" EXACT []
xref: Wikipedia:Signal_recognition_particle
is_a: GO:0048500 ! signal recognition particle

[Term]
id: GO:0005787
name: signal peptidase complex
namespace: cellular_component
def: "A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0005788
name: endoplasmic reticulum lumen
namespace: cellular_component
alt_id: GO:0016022
def: "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684]
synonym: "cisternal lumen" EXACT []
synonym: "endoplasmic reticulum cisterna" EXACT []
synonym: "ER cisterna" EXACT []
synonym: "ER lumen" EXACT []
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0070013 ! intracellular organelle lumen

[Term]
id: GO:0005789
name: endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah]
synonym: "ER membrane" EXACT []
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0042175 ! nuclear envelope-endoplasmic reticulum network

[Term]
id: GO:0005790
name: smooth endoplasmic reticulum
namespace: cellular_component
def: "The smooth endoplasmic reticulum (ER) has with no ribosomes attached to it. The smooth is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "SER" EXACT []
synonym: "smooth ER" EXACT []
xref: NIF_Subcellular:sao710427438
xref: Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum
is_a: GO:0005783 ! endoplasmic reticulum
is_a: GO:0071212 ! subsynaptic reticulum

[Term]
id: GO:0005791
name: rough endoplasmic reticulum
namespace: cellular_component
def: "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "RER" EXACT []
synonym: "rough ER" EXACT []
xref: NIF_Subcellular:sao1881364067
xref: Wikipedia:Endoplasmic_reticulum#Rough_endoplasmic_reticulum
is_a: GO:0005783 ! endoplasmic reticulum
is_a: GO:0071212 ! subsynaptic reticulum

[Term]
id: GO:0005792
name: microsome
namespace: cellular_component
def: "Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
synonym: "microsomal membrane" RELATED []
xref: Wikipedia:Microsome
is_a: GO:0042598 ! vesicular fraction

[Term]
id: GO:0005793
name: ER-Golgi intermediate compartment
namespace: cellular_component
def: "A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport." [PMID:16723730]
synonym: "endoplasmic reticulum-Golgi intermediate compartment" EXACT []
synonym: "ERGIC" EXACT []
synonym: "pre-Golgi intermediate compartment" EXACT []
synonym: "vesicular-tubular cluster" EXACT [Wikipedia:Vesicular-tubular_cluster]
xref: Wikipedia:Vesicular-tubular_cluster
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005794
name: Golgi apparatus
namespace: cellular_component
def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
synonym: "Golgi" BROAD []
synonym: "Golgi complex" EXACT []
synonym: "Golgi ribbon" NARROW []
xref: NIF_Subcellular:sao451912436
xref: Wikipedia:Golgi_apparatus
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005795
name: Golgi stack
namespace: cellular_component
alt_id: GO:0016940
def: "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194]
synonym: "dictyosome" NARROW []
synonym: "Golgi cisternae" EXACT []
is_a: GO:0044431 ! Golgi apparatus part

[Term]
id: GO:0005796
name: Golgi lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks." [GOC:mah]
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0070013 ! intracellular organelle lumen

[Term]
id: GO:0005797
name: Golgi medial cisterna
namespace: cellular_component
def: "The middle Golgi cisterna (or cisternae)." [ISBN:0815316194]
is_a: GO:0031985 ! Golgi cisterna

[Term]
id: GO:0005798
name: Golgi-associated vesicle
namespace: cellular_component
def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah]
comment: Note that this definition includes vesicles that are transiently associated with the Golgi.
synonym: "Golgi vesicle" RELATED []
xref: NIF_Subcellular:sao819927218
is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle
is_a: GO:0044431 ! Golgi apparatus part

[Term]
id: GO:0005799
name: coatomer
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because its position and synonym implied that it confused a coated vesicle with the coat itself.
synonym: "COPI vesicle" RELATED []
is_obsolete: true
consider: GO:0030126
consider: GO:0030137

[Term]
id: GO:0005800
name: COPII vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
is_obsolete: true
consider: GO:0030134

[Term]
id: GO:0005801
name: cis-Golgi network
namespace: cellular_component
def: "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815316194]
synonym: "cis Golgi network" EXACT []
synonym: "forming face" RELATED []
synonym: "Golgi cis face" RELATED []
synonym: "Golgi cis-face" RELATED []
is_a: GO:0044431 ! Golgi apparatus part

[Term]
id: GO:0005802
name: trans-Golgi network
namespace: cellular_component
def: "The network of interconnected tubular and cisternal structures located at the side of the Golgi apparatus distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194]
synonym: "Golgi trans face" RELATED []
synonym: "Golgi trans-face" RELATED []
synonym: "late Golgi" RELATED [GOC:mah]
synonym: "maturing face" RELATED []
synonym: "TGN" EXACT []
synonym: "trans Golgi network" EXACT []
xref: NIF_Subcellular:sao9456487
is_a: GO:0044431 ! Golgi apparatus part

[Term]
id: GO:0005803
name: secretory vesicle
namespace: cellular_component
def: "OBSOLETE. A small subcellular vesicle, or granule, surrounded by a single-layered membrane; formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [ISBN:0198547684]
comment: This term was made obsolete because it was being used to describe two different components.
synonym: "transition vesicle" NARROW []
is_obsolete: true
consider: GO:0030133
consider: GO:0030141

[Term]
id: GO:0005804
name: secretory vesicle membrane
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because its parent was made obsolete.
is_obsolete: true
consider: GO:0030658
consider: GO:0030667

[Term]
id: GO:0005805
name: ER-Golgi transport vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
is_obsolete: true
consider: GO:0030134

[Term]
id: GO:0005806
name: Golgi-ER transport vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
is_obsolete: true
consider: GO:0030142

[Term]
id: GO:0005808
name: Golgi-plasma membrane transport vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; a personal communication from John Armstrong indicated that a replacement term was not required, as TGN-Golgi transport is likely to be mediated by tubules rather than vesicles.
is_obsolete: true
consider: GO:0030133

[Term]
id: GO:0005809
name: Golgi-vacuole transport vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
is_obsolete: true
consider: GO:0030133

[Term]
id: GO:0005810
name: endocytotic transport vesicle
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required.
is_obsolete: true
replaced_by: GO:0030139

[Term]
id: GO:0005811
name: lipid particle
namespace: cellular_component
def: "Any particle of coalesced lipids in the cytoplasm of a cell. May include associated proteins." [GOC:mah]
comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers.
subset: goslim_generic
synonym: "adiposome" EXACT []
synonym: "lipid body" EXACT []
synonym: "lipid droplet" EXACT []
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005813
name: centrosome
namespace: cellular_component
def: "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684]
subset: goslim_pir
xref: Wikipedia:Centrosome
is_a: GO:0005815 ! microtubule organizing center
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0005814
name: centriole
namespace: cellular_component
def: "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684]
xref: NIF_Subcellular:sao95019936
xref: Wikipedia:Centriole
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0005815
name: microtubule organizing center
namespace: cellular_component
def: "A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [ISBN:0815316194, PMID:17245416]
subset: goslim_candida
subset: goslim_generic
subset: goslim_yeast
synonym: "microtubule organising centre" EXACT []
synonym: "MTOC" EXACT []
xref: Wikipedia:Microtubule_organizing_center
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005816
name: spindle pole body
namespace: cellular_component
def: "The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome." [ISBN:0879693568]
xref: Wikipedia:Spindle_pole_body
is_a: GO:0005815 ! microtubule organizing center
relationship: part_of GO:0000922 ! spindle pole

[Term]
id: GO:0005817
name: centrosomal mitotic factor
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:clt]
comment: This term was made obsolete because it was not defined.
is_obsolete: true

[Term]
id: GO:0005818
name: aster
namespace: cellular_component
def: "An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores." [GOC:clt]
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0005819
name: spindle
namespace: cellular_component
def: "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684]
xref: Wikipedia:Spindle_apparatus
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005821
name: intermediate layer of spindle pole body
namespace: cellular_component
def: "Structure between the central and outer plaques of the spindle pole body." [PMID:9215630]
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005822
name: inner plaque of spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus." [ISBN:0879693568]
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005823
name: central plaque of spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope." [ISBN:0879693568]
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005824
name: outer plaque of spindle pole body
namespace: cellular_component
def: "One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm." [ISBN:0879693568]
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005825
name: half bridge of spindle pole body
namespace: cellular_component
def: "Structure adjacent to the plaques of the spindle pole body." [ISBN:0879693568]
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0005826
name: actomyosin contractile ring
namespace: cellular_component
alt_id: GO:0030480
def: "A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, ISBN:0805319409, ISBN:0815316194]
synonym: "actomyosin ring" RELATED []
synonym: "CAR" EXACT []
synonym: "constriction ring" RELATED []
synonym: "contractile actomyosin ring" EXACT []
synonym: "cytokinetic ring" NARROW []
is_a: GO:0032155 ! cell division site part
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
is_a: GO:0070938 ! contractile ring
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0005827
name: polar microtubule
namespace: cellular_component
def: "Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart." [ISBN:0815316194]
synonym: "pole-to-pole microtubule" EXACT []
is_a: GO:0005876 ! spindle microtubule
relationship: part_of GO:0000922 ! spindle pole

[Term]
id: GO:0005828
name: kinetochore microtubule
namespace: cellular_component
def: "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194]
synonym: "pole-to-kinetochore microtubule" EXACT []
is_a: GO:0005876 ! spindle microtubule

[Term]
id: GO:0005829
name: cytosol
namespace: cellular_component
def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hgd, GOC:jl]
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
xref: NIF_Subcellular:sao101633890
xref: Wikipedia:Cytosol
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005831
name: steroid hormone aporeceptor complex
namespace: cellular_component
def: "A protein complex consisting of a steroid receptor associated with nonreceptor proteins, minimally a dimer of Hsp90 and a monomer of hsp56/FKBP59; forms in the absence of bound ligand." [PMID:7493981]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005832
name: chaperonin-containing T-complex
namespace: cellular_component
def: "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267]
synonym: "CCT particle" EXACT []
synonym: "TriC" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005833
name: hemoglobin complex
namespace: cellular_component
def: "An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "haemoglobin complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005834
name: heterotrimeric G-protein complex
namespace: cellular_component
def: "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684]
comment: See also the molecular function term 'G-protein coupled receptor activity ; GO:0004930'.
subset: gosubset_prok
synonym: "heterotrimeric G-protein GTPase activity" RELATED []
synonym: "heterotrimeric G-protein GTPase, alpha-subunit" NARROW []
synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW []
synonym: "heterotrimeric G-protein GTPase, gamma-subunit" NARROW []
is_a: GO:0019897 ! extrinsic to plasma membrane
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0005835
name: fatty acid synthase complex
namespace: cellular_component
def: "A multienzyme complex required to convert carbohydrates to fatty acids, specifically acetyl CoA to palmitate." [GOC:sgd_curators, ISBN:0716746840]
subset: goslim_pir
subset: gosubset_prok
synonym: "FAS complex" EXACT []
synonym: "fatty acid synthetase complex" EXACT []
synonym: "holo-[acyl-carrier-protein] synthase complex" RELATED []
xref: Wikipedia:Fatty_acid_synthetase_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005836
name: fatty-acyl-CoA synthase complex
namespace: cellular_component
def: "A protein complex that possesses fatty-acyl-CoA synthase activity." [BRENDA:2.3.1.86, GOC:mah]
comment: Note that fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, whereas the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes.
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005837
name: 26S proteasome
namespace: cellular_component
def: "OBSOLETE. A large multisubunit protease found in the cytosol that recognizes, unfolds, and digests protein substrates that have been marked for degradation by the attachment of a ubiquitin moiety. Individual subcomplexes of the complete 26S proteasome are involved in these different tasks: the ATP-dependent 19S caps are believed to unfold substrates and feed them to the actual protease, the 20S proteasome." [PMID:10410804]
comment: This term was made obsolete because its definition was inaccurate.
is_obsolete: true
consider: GO:0000502

[Term]
id: GO:0005838
name: proteasome regulatory particle
namespace: cellular_component
def: "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:proteasome, GOC:rb]
synonym: "19S regulatory particle" NARROW []
synonym: "modulator complex" RELATED [CORUM:28]
synonym: "PA700 proteasome activator" NARROW []
synonym: "PA700-dependent proteasome activator" EXACT [CORUM:28]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0022624 ! proteasome accessory complex

[Term]
id: GO:0005839
name: proteasome core complex
namespace: cellular_component
alt_id: GO:0000503
def: "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206]
synonym: "20S core complex" NARROW []
synonym: "20S proteasome" NARROW [GOC:cjk]
synonym: "macropain" EXACT []
synonym: "PA28gamma-20S proteasome" NARROW [CORUM:194]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0000502 ! proteasome complex

[Term]
id: GO:0005840
name: ribosome
namespace: cellular_component
def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "ribosomal RNA" RELATED []
xref: NIF_Subcellular:sao1429207766
xref: Wikipedia:Ribosome
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005844
name: polysome
namespace: cellular_component
def: "Several ribosomes bound to one mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
synonym: "polyribosome" EXACT []
xref: Wikipedia:Polysome
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0005845
name: mRNA cap binding complex
namespace: cellular_component
def: "Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA." [GOC:jic]
synonym: "mRNA cap complex" RELATED []
is_a: GO:0034518 ! RNA cap binding complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005846
name: nuclear cap binding complex
namespace: cellular_component
def: "A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export." [PMID:16043498]
comment: Note that this complex can be found in the cytoplasm as well as the nucleus.
synonym: "CBC" RELATED []
synonym: "mRNA cap binding complex" NARROW []
synonym: "NCBP-NIP1 complex" NARROW []
synonym: "snRNA cap binding complex" NARROW []
is_a: GO:0034518 ! RNA cap binding complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005847
name: mRNA cleavage and polyadenylation specificity factor complex
namespace: cellular_component
def: "A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727]
synonym: "CFII complex" RELATED []
synonym: "cleavage and polyadenylylation specificity factor activity" RELATED []
synonym: "CPF complex" NARROW []
synonym: "CPSF complex" NARROW []
is_a: GO:0005849 ! mRNA cleavage factor complex

[Term]
id: GO:0005848
name: mRNA cleavage stimulating factor complex
namespace: cellular_component
def: "A protein complex required for mRNA cleavage but not for poly(A) addition." [GOC:mah, PMID:10357856]
synonym: "cleavage stimulation factor activity" RELATED []
synonym: "CstF complex" NARROW []
is_a: GO:0005849 ! mRNA cleavage factor complex

[Term]
id: GO:0005849
name: mRNA cleavage factor complex
namespace: cellular_component
def: "Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0005850
name: eukaryotic translation initiation factor 2 complex
namespace: cellular_component
def: "Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA." [PMID:10216940]
synonym: "eIF-2" EXACT []
synonym: "eIF2" EXACT [GOC:mah]
xref: Wikipedia:EIF-2
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005851
name: eukaryotic translation initiation factor 2B complex
namespace: cellular_component
def: "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375]
synonym: "eIF-2B" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005852
name: eukaryotic translation initiation factor 3 complex
namespace: cellular_component
def: "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532]
synonym: "eIF-3" EXACT []
synonym: "eIF3" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005853
name: eukaryotic translation elongation factor 1 complex
namespace: cellular_component
def: "A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005854
name: nascent polypeptide-associated complex
namespace: cellular_component
def: "A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:12475173, PMID:7568149]
synonym: "NAC" EXACT []
synonym: "NACA" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005856
name: cytoskeleton
namespace: cellular_component
def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Cytoskeleton
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0005858
name: axonemal dynein complex
namespace: cellular_component
def: "A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. May contain two or three dynein heavy chains as well as several light chains." [ISBN:0815316194]
synonym: "axonemal dynein heavy chain" NARROW []
synonym: "axonemal dynein intermediate chain" NARROW []
synonym: "axonemal dynein intermediate light chain" NARROW []
synonym: "axonemal dynein light chain" NARROW []
is_a: GO:0030286 ! dynein complex
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0005859
name: muscle myosin complex
namespace: cellular_component
def: "A filament of myosin found in a muscle cell of any type." [GOC:mah]
is_a: GO:0016460 ! myosin II complex
is_a: GO:0044449 ! contractile fiber part

[Term]
id: GO:0005861
name: troponin complex
namespace: cellular_component
def: "A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction." [ISBN:0815316194]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0005865 ! striated muscle thin filament

[Term]
id: GO:0005862
name: muscle thin filament tropomyosin
namespace: cellular_component
def: "A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments." [ISBN:0815316194]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0005865 ! striated muscle thin filament

[Term]
id: GO:0005863
name: striated muscle thick filament
namespace: cellular_component
def: "Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils." [GOC:mtg_muscle, ISBN:0815316194]
is_a: GO:0005859 ! muscle myosin complex
is_a: GO:0032982 ! myosin filament
relationship: part_of GO:0030017 ! sarcomere

[Term]
id: GO:0005865
name: striated muscle thin filament
namespace: cellular_component
def: "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0015629 ! actin cytoskeleton
relationship: part_of GO:0030017 ! sarcomere

[Term]
id: GO:0005868
name: cytoplasmic dynein complex
namespace: cellular_component
def: "Any dynein complex that catalyzes movement along a cytoplasmic microtubule; cytoplasmic dynein complexes participates in many transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes,and may include light chains and light intermediate chains." [GOC:mah, PMID:12600311]
synonym: "cytoplasmic dynein heavy chain" NARROW []
synonym: "cytoplasmic dynein intermediate chain" NARROW []
synonym: "cytoplasmic dynein intermediate light chain" NARROW []
synonym: "cytoplasmic dynein light chain" NARROW []
is_a: GO:0030286 ! dynein complex

[Term]
id: GO:0005869
name: dynactin complex
namespace: cellular_component
def: "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0005875 ! microtubule associated complex
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0005870
name: actin capping protein of dynactin complex
namespace: cellular_component
def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex." [GOC:jl, PMID:18221362, PMID:18544499]
is_a: GO:0008290 ! F-actin capping protein complex
relationship: part_of GO:0005869 ! dynactin complex

[Term]
id: GO:0005871
name: kinesin complex
namespace: cellular_component
def: "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
is_a: GO:0005875 ! microtubule associated complex

[Term]
id: GO:0005872
name: minus-end kinesin complex
namespace: cellular_component
def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule." [GOC:mah]
is_a: GO:0005871 ! kinesin complex

[Term]
id: GO:0005873
name: plus-end kinesin complex
namespace: cellular_component
def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule." [GOC:mah]
is_a: GO:0005871 ! kinesin complex

[Term]
id: GO:0005874
name: microtubule
namespace: cellular_component
def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568]
xref: NIF_Subcellular:sao1846835077
xref: Wikipedia:Microtubule
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005875
name: microtubule associated complex
namespace: cellular_component
def: "Any multimeric complex connected to a microtubule." [GOC:jl]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0005876
name: spindle microtubule
namespace: cellular_component
def: "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194]
is_a: GO:0005874 ! microtubule
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0005879
name: axonemal microtubule
namespace: cellular_component
def: "A microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [ISBN:0815316194]
is_a: GO:0005874 ! microtubule
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0005880
name: nuclear microtubule
namespace: cellular_component
def: "Any microtubule in the nucleus of a cell." [GOC:mah]
is_a: GO:0005874 ! microtubule
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0005881
name: cytoplasmic microtubule
namespace: cellular_component
def: "Any microtubule in the cytoplasm of a cell." [GOC:mah]
synonym: "non-spindle-associated astral microtubule" NARROW []
is_a: GO:0005874 ! microtubule

[Term]
id: GO:0005882
name: intermediate filament
namespace: cellular_component
def: "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "intermediate filament associated protein" RELATED []
synonym: "type I intermediate filament associated protein" RELATED []
synonym: "type II intermediate filament associated protein" RELATED []
xref: NIF_Subcellular:sao952483289
xref: Wikipedia:Intermediate_filament
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0045111 ! intermediate filament cytoskeleton

[Term]
id: GO:0005883
name: neurofilament
namespace: cellular_component
def: "A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363, ISBN:0815316194]
synonym: "type IV intermediate filament" EXACT []
xref: NIF_Subcellular:sao1316272517
xref: Wikipedia:Neurofilament
is_a: GO:0005882 ! intermediate filament
relationship: part_of GO:0060053 ! neurofilament cytoskeleton

[Term]
id: GO:0005884
name: actin filament
namespace: cellular_component
def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:10666339]
synonym: "microfilament" EXACT []
xref: NIF_Subcellular:sao1588493326
xref: Wikipedia:Actin
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0005885
name: Arp2/3 protein complex
namespace: cellular_component
def: "A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments." [GOC:jl, GOC:vw, PMID:12479800]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0005886
name: plasma membrane
namespace: cellular_component
alt_id: GO:0005904
def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363]
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "bacterial inner membrane" NARROW []
synonym: "cell membrane" EXACT []
synonym: "cytoplasmic membrane" EXACT []
synonym: "inner endospore membrane" NARROW []
synonym: "juxtamembrane" BROAD []
synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah]
synonym: "plasmalemma" EXACT []
xref: NIF_Subcellular:sao1663586795
xref: Wikipedia:Cell_membrane
is_a: GO:0016020 ! membrane

[Term]
id: GO:0005887
name: integral to plasma membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0016021 ! integral to membrane
is_a: GO:0031226 ! intrinsic to plasma membrane

[Term]
id: GO:0005888
name: proteoglycan integral to plasma membrane
namespace: cellular_component
def: "OBSOLETE. Penetrating at least one phospholipid bilayer of a plasma membrane and consisting of proteoglycan. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators]
comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) and not the location of a gene product.
is_obsolete: true
replaced_by: GO:0005887

[Term]
id: GO:0005889
name: hydrogen:potassium-exchanging ATPase complex
namespace: cellular_component
def: "A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of Na+ and K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present." [PMID:11756431]
synonym: "hydrogen/potassium-exchanging ATPase complex" EXACT []
synonym: "proton pump" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005890
name: sodium:potassium-exchanging ATPase complex
namespace: cellular_component
def: "Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "sodium pump" BROAD []
synonym: "sodium/potassium-exchanging ATPase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005891
name: voltage-gated calcium channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah]
subset: goslim_pir
synonym: "voltage gated calcium channel complex" EXACT []
synonym: "voltage-dependent calcium channel complex" EXACT []
synonym: "voltage-sensitive calcium channel complex" EXACT []
is_a: GO:0034704 ! calcium channel complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0005892
name: nicotinic acetylcholine-gated receptor-channel complex
namespace: cellular_component
def: "A protein complex that acts as an acetylcholine receptor, and forms a transmembrane channel through which ions may pass in response to ligand binding. The complex is a homo- or heteropentamer of subunits that are members of a neurotransmitter receptor superfamily." [GOC:mah, PMID:12381728, PMID:15579462]
synonym: "nicotinic acetylcholine receptor" BROAD []
is_a: GO:0034702 ! ion channel complex
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005893
name: interleukin-2 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-2; comprises alpha, beta, and gamma subunits." [GOC:mah, PMID:3116143, PMID:8266078]
synonym: "IL-2 receptor complex" EXACT [GOC:add]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005894
name: interleukin-3 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5." [PMID:11839579]
synonym: "IL-3 receptor complex" EXACT [GOC:add]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005895
name: interleukin-5 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3." [GOC:mah, PMID:11312115, PMID:11839579]
synonym: "IL-5 receptor complex" EXACT [GOC:add]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005896
name: interleukin-6 receptor complex
namespace: cellular_component
def: "A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130." [PMID:8083235]
synonym: "IL-6 receptor complex" EXACT [GOC:add]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005897
name: interleukin-9 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins." [GOC:mah, PMID:10642536]
synonym: "IL-9 receptor complex" EXACT [GOC:add]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005898
name: interleukin-13 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-13; consists of two chains, interleukin-13 receptor alpha1 chain and interleukin-4 receptor alpha chain." [PMID:8552669, PMID:9013879]
synonym: "IL-13 receptor complex" EXACT [GOC:add]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005899
name: insulin receptor complex
namespace: cellular_component
def: "A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005900
name: oncostatin-M receptor complex
namespace: cellular_component
def: "A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta." [GOC:jl, PMID:8999038]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0005901
name: caveola
namespace: cellular_component
alt_id: GO:0016599
def: "A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include any of the minute pits or incuppings of the cell membrane formed during pinocytosis. Such caveolae may be pinched off to form free vesicles within the cytoplasm." [GOC:mah, http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "caveolae" EXACT []
synonym: "caveolar membrane" RELATED []
xref: Wikipedia:Caveolae
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045121 ! membrane raft

[Term]
id: GO:0005902
name: microvillus
namespace: cellular_component
def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0813516194]
comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta.
subset: goslim_pir
xref: Wikipedia:Microvillus
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0005903
name: brush border
namespace: cellular_component
def: "Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194]
subset: goslim_pir
xref: Wikipedia:Brush_border
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0005905
name: coated pit
namespace: cellular_component
def: "A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:10559856, PMID:17284835]
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0005906
name: clathrin adaptor
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was positioned incorrectly, so the replacement term has a definition different from what this term appeared to mean.
synonym: "adaptin" RELATED []
is_obsolete: true
replaced_by: GO:0030119

[Term]
id: GO:0005907
name: HA1 clathrin adaptor
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous.
synonym: "AP1" RELATED []
is_obsolete: true
consider: GO:0030121

[Term]
id: GO:0005908
name: HA2 clathrin adaptor
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous.
synonym: "AP2" RELATED []
is_obsolete: true
consider: GO:0030122

[Term]
id: GO:0005911
name: cell-cell junction
namespace: cellular_component
def: "A cell junction that forms a connection between two cells; excludes direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb, GOC:mah]
synonym: "intercellular junction" EXACT []
xref: NIF_Subcellular:sao1922892319
is_a: GO:0030054 ! cell junction

[Term]
id: GO:0005912
name: adherens junction
namespace: cellular_component
def: "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0070161 ! anchoring junction

[Term]
id: GO:0005913
name: cell-cell adherens junction
namespace: cellular_component
def: "An adherens junction which connects two cells to each other." [GOC:hb]
is_a: GO:0005911 ! cell-cell junction
is_a: GO:0005912 ! adherens junction

[Term]
id: GO:0005914
name: spot adherens junction
namespace: cellular_component
def: "A small junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens." [PMID:11700298]
synonym: "dense plaque" BROAD []
synonym: "punctum adherens" EXACT []
is_a: GO:0005913 ! cell-cell adherens junction

[Term]
id: GO:0005915
name: zonula adherens
namespace: cellular_component
def: "A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208]
synonym: "adhesion belt" EXACT []
synonym: "belt desmosome" EXACT []
synonym: "fascia adhaerens" EXACT []
synonym: "intermediate junction" EXACT []
synonym: "zonula adhaerens" EXACT []
xref: NIF_Subcellular:sao1400623473
is_a: GO:0005913 ! cell-cell adherens junction
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0005916
name: fascia adherens
namespace: cellular_component
def: "A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes." [GOC:mtg_muscle, http://cancerweb.ncl.ac.uk, PMID:11732910]
xref: Wikipedia:Fascia_adherens
is_a: GO:0005913 ! cell-cell adherens junction
relationship: part_of GO:0014704 ! intercalated disc

[Term]
id: GO:0005917
name: nephrocyte junction
namespace: cellular_component
def: "A tissue-specific adherens junction found in kidney cells." [http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm]
is_a: GO:0005913 ! cell-cell adherens junction

[Term]
id: GO:0005918
name: septate junction
namespace: cellular_component
def: "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298]
synonym: "septate desmosome" RELATED []
xref: NIF_Subcellular:sao427941916
is_a: GO:0070160 ! occluding junction
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0005919
name: pleated septate junction
namespace: cellular_component
def: "A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298]
synonym: "pleated desmosome" RELATED []
is_a: GO:0005918 ! septate junction

[Term]
id: GO:0005920
name: smooth septate junction
namespace: cellular_component
def: "A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298]
synonym: "zonula continua" EXACT []
is_a: GO:0005918 ! septate junction

[Term]
id: GO:0005921
name: gap junction
namespace: cellular_component
def: "A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181]
synonym: "communicating junction" EXACT []
synonym: "macula communicans" EXACT []
synonym: "zonula communicans" EXACT []
xref: NIF_Subcellular:sao118541872
xref: Wikipedia:Gap_junction
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0005922
name: connexon complex
namespace: cellular_component
def: "An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction." [PMID:11146276]
xref: NIF_Subcellular:sao445019788
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005921 ! gap junction

[Term]
id: GO:0005923
name: tight junction
namespace: cellular_component
def: "An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181]
synonym: "zonula occludens" EXACT []
xref: NIF_Subcellular:sao1939999134
xref: Wikipedia:Tight_junction
is_a: GO:0070160 ! occluding junction
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0005924
name: cell-substrate adherens junction
namespace: cellular_component
def: "An adherens junction which connects a cell to the extracellular matrix." [GOC:hb]
synonym: "hemi-adherens junction" RELATED []
is_a: GO:0005912 ! adherens junction
is_a: GO:0030055 ! cell-substrate junction

[Term]
id: GO:0005925
name: focal adhesion
namespace: cellular_component
alt_id: GO:0008357
def: "Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208]
synonym: "focal contact" EXACT []
synonym: "hemi-adherens junction" RELATED []
xref: Wikipedia:Focal_adhesion
is_a: GO:0005924 ! cell-substrate adherens junction

[Term]
id: GO:0005926
name: connecting hemi-adherens junction
namespace: cellular_component
def: "A cell-substrate adherens junction, also known as a hemiadherens junction (HAJ) that forms one of a pair of junctions in opposing cells that are separated by only 30-40nm, with a thin line of extracellular electron-dense material in between; found where muscles attach to epidermal cells directly (in insects)." [http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm]
is_a: GO:0005924 ! cell-substrate adherens junction

[Term]
id: GO:0005927
name: muscle tendon junction
namespace: cellular_component
def: "A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007]
synonym: "myotendinous junction" EXACT []
is_a: GO:0005924 ! cell-substrate adherens junction

[Term]
id: GO:0005928
name: apical hemi-adherens junction
namespace: cellular_component
def: "A cell-substrate adherens junction found in the apical region of a cell, such as those found in cuticle-secreting epithelia, which connect the apical membrane to the cuticle." [GOC:mah, PMID:11700298]
synonym: "apical cell-substrate adherens junction" EXACT [GOC:mah]
synonym: "apical dense plaque" EXACT []
is_a: GO:0005924 ! cell-substrate adherens junction

[Term]
id: GO:0005929
name: cilium
namespace: cellular_component
def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, ISBN:0198547684]
subset: goslim_generic
subset: goslim_pir
xref: NIF_Subcellular:sao787716553
xref: Wikipedia:Cilium
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0005930
name: axoneme
namespace: cellular_component
def: "The bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements." [ISBN:0198547684]
xref: Wikipedia:Axoneme
is_a: GO:0044422 ! organelle part
is_a: GO:0044424 ! intracellular part
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0005931
name: nexin complex
namespace: cellular_component
def: "A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0005932
name: microtubule basal body
namespace: cellular_component
def: "A short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium or flagellum that is similar in structure to a centriole. The basal body serves as a nucleation site for axoneme growth." [GOC:clt]
xref: NIF_Subcellular:sao11978067
is_a: GO:0005815 ! microtubule organizing center
is_a: GO:0044463 ! cell projection part

[Term]
id: GO:0005933
name: cellular bud
namespace: cellular_component
def: "A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated." [GOC:sgd_curators]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005934
name: cellular bud tip
namespace: cellular_component
def: "The end of a cellular bud distal to the site of attachment to the mother cell." [GOC:mah]
is_a: GO:0030427 ! site of polarized growth
relationship: part_of GO:0005933 ! cellular bud

[Term]
id: GO:0005935
name: cellular bud neck
namespace: cellular_component
def: "The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding." [GOC:mah]
is_a: GO:0030427 ! site of polarized growth
relationship: part_of GO:0005933 ! cellular bud

[Term]
id: GO:0005936
name: shmoo
namespace: cellular_component
def: "OBSOLETE. The characteristic projection formed in response to mating pheromone by cells of Saccharomyces and other fungi with similar life cycles. Named after the Al Capp cartoon character, whose shape it resembles." [GOC:mah, GOC:mcc]
comment: This term was made obsolete because it represents a type of whole cell rather than a cellular component. To update annotations, consider the external ontology term 'shmoo ; FAO:0001023'.
is_obsolete: true
consider: GO:0001400
consider: GO:0005937

[Term]
id: GO:0005937
name: mating projection
namespace: cellular_component
def: "The projection formed by unicellular fungi in response to mating pheromone." [GOC:mcc]
subset: goslim_pir
synonym: "conjugation tube" NARROW []
synonym: "shmoo" NARROW []
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0005938
name: cell cortex
namespace: cellular_component
def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_yeast
synonym: "cell periphery" RELATED []
synonym: "peripheral cytoplasm" RELATED []
xref: Wikipedia:Cell_cortex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005940
name: septin ring
namespace: cellular_component
alt_id: GO:0030481
def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form." [GOC:krc, GOC:mah, PMID:16009555, PMID:16151244]
xref: Wikipedia:Septin_ring
is_a: GO:0032156 ! septin cytoskeleton
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0005941
name: unlocalized protein complex
namespace: cellular_component
def: "OBSOLETE. Used as a holding place for cellular components whose precise localization is, as yet, unknown, or has not been determined by GO (the latter is the major reason for nodes to have this parent); this term should not be used for annotation of gene products." [GOC:ma]
comment: This term was made obsolete because it was originally intended only as a temporary parent for protein complex terms for which no more specific parents had been found. This term no longer has any children: All protein complex terms are is_a 'protein complex ; GO:0043234' and nearly all have been placed under parents to yield more specific paths traversing a part_of relationship. In other words, the term has been superseded by other terms and relationships in the cellular component ontology, and is no longer needed.
is_obsolete: true

[Term]
id: GO:0005942
name: phosphoinositide 3-kinase complex
namespace: cellular_component
def: "A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K)." [GOC:bf]
subset: goslim_pir
synonym: "1-phosphatidylinositol 3-kinase complex" EXACT []
synonym: "phosphatidylinositol 3-kinase complex" EXACT [CORUM:429]
synonym: "PI3-kinase p85-subunit alpha- PI3-kinase p110 complex" NARROW [CORUM:2575]
synonym: "PI3K complex" EXACT []
synonym: "PIK3C3-PIK3R4 complex" NARROW [CORUM:429]
synonym: "PIK3CA-PIK3R1 complex" NARROW [CORUM:439]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005943
name: 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
namespace: cellular_component
alt_id: GO:0035030
def: "A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IA phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways." [PMID:9255069, PMID:9759495]
synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA complex" EXACT []
synonym: "class IA PI3K complex" EXACT []
synonym: "phosphoinositide 3-kinase complex, class IA" EXACT []
is_a: GO:0005942 ! phosphoinositide 3-kinase complex

[Term]
id: GO:0005944
name: 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
namespace: cellular_component
alt_id: GO:0035031
def: "A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IB phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks." [PMID:9255069, PMID:9759495]
synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB complex" RELATED []
synonym: "class IB PI3K complex" EXACT []
synonym: "phosphoinositide 3-kinase complex, class IB" EXACT []
is_a: GO:0005942 ! phosphoinositide 3-kinase complex

[Term]
id: GO:0005945
name: 6-phosphofructokinase complex
namespace: cellular_component
def: "A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known." [GOC:mah, GOC:vw, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0005946
name: alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
namespace: cellular_component
def: "A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present." [PMID:9837904]
comment: See also the molecular function term 'alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity ; GO:0003825'.
synonym: "trehalose-6-phosphate synthase complex" EXACT []
synonym: "trehalose-6-phosphate synthase/phosphatase" EXACT []
synonym: "UDP-glucose-glucosephosphate glucosyltransferase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005947
name: mitochondrial alpha-ketoglutarate dehydrogenase complex
namespace: cellular_component
def: "Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu]
synonym: "2-oxoglutarate dehydrogenase complex" BROAD []
is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex
is_a: GO:0045240 ! dihydrolipoyl dehydrogenase complex

[Term]
id: GO:0005948
name: acetolactate synthase complex
namespace: cellular_component
def: "A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate." [BRENDA:2.2.1.6, GOC:jl, PMID:16458324, PMID:8756689]
comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'.
subset: gosubset_prok
synonym: "acetohydroxyacid synthase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005949
name: aminoadipate-semialdehyde dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. A heterodimeric enzyme composed of an alpha and beta subunit. Catalyzes the formation of L-2-aminoadipate from L-2-aminoadipate 6-semialdehyde." [EC:1.2.1.31]
comment: This term was made obsolete because the catalytic activity resides in a single polypeptide that is not part of a complex with other gene products.
is_obsolete: true

[Term]
id: GO:0005950
name: anthranilate synthase complex
namespace: cellular_component
def: "A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine." [EC:4.1.3.27, MetaCyc:ANTHRANSYN-CPLX, PMID:4886290]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005951
name: carbamoyl-phosphate synthase complex
namespace: cellular_component
def: "A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia moiety cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events." [PMID:8626695]
comment: Note that in higher eukaryotes, carbamoyl-phosphate synthase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term.
subset: gosubset_prok
synonym: "arginine-specific carbamoyl phosphate synthetase complex" NARROW []
synonym: "carbamoyl phosphate synthase complex" EXACT []
synonym: "carbamoyl-phosphate synthase arginine-specific complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005952
name: cAMP-dependent protein kinase complex
namespace: cellular_component
def: "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "3',5' cAMP-dependent protein kinase complex" EXACT []
synonym: "3',5'-cAMP-dependent protein kinase complex" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase complex" EXACT []
synonym: "cyclic AMP-dependent protein kinase complex" EXACT []
synonym: "PKA" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005953
name: CAAX-protein geranylgeranyltransferase complex
namespace: cellular_component
def: "A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane." [PMID:9781874]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005954
name: calcium- and calmodulin-dependent protein kinase complex
namespace: cellular_component
def: "An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins." [EC:2.7.11.17]
synonym: "calcium/calmodulin-dependent protein kinase complex" EXACT []
synonym: "CAMK2" EXACT []
synonym: "CaMKII" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005955
name: calcineurin complex
namespace: cellular_component
def: "A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [ISBN:019859951]
synonym: "calcium-dependent protein serine/threonine phosphatase complex" NARROW []
synonym: "protein phosphatase type 2B complex" EXACT []
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005956
name: protein kinase CK2 complex
namespace: cellular_component
def: "A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein." [GOC:mah, PMID:10994779]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex.
synonym: "casein kinase II complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005957
name: debranching enzyme
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is ambiguous (there are several debranching enzymes) and because it probably represents the glycogen debranching enzyme which is a single gene product and not a complex.
is_obsolete: true
consider: GO:0043033

[Term]
id: GO:0005958
name: DNA-dependent protein kinase-DNA ligase 4 complex
namespace: cellular_component
alt_id: GO:0005959
def: "A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV." [GOC:jl, GOC:mah, PMID:10854421, PMID:12235392, PMID:17072889]
is_a: GO:0044428 ! nuclear part
is_a: GO:0070419 ! nonhomologous end joining complex

[Term]
id: GO:0005960
name: glycine cleavage complex
namespace: cellular_component
alt_id: GO:0005961
alt_id: GO:0070015
def: "A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T." [GOC:mah, MetaCyc:GCVMULTI-CPLX]
subset: goslim_pir
subset: gosubset_prok
synonym: "glycine cleavage system" EXACT []
synonym: "glycine decarboxylase complex" EXACT []
synonym: "glycine dehydrogenase (decarboxylating) complex" EXACT []
synonym: "glycine dehydrogenase complex (decarboxylating)" RELATED []
synonym: "glycine synthase complex" EXACT []
xref: Wikipedia:Glycine_decarboxylase_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005962
name: mitochondrial isocitrate dehydrogenase complex (NAD+)
namespace: cellular_component
def: "Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'isocitrate dehydrogenase (NAD+) activity ; GO:0004449'.
is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex
is_a: GO:0045242 ! isocitrate dehydrogenase complex (NAD+)

[Term]
id: GO:0005963
name: magnesium-dependent protein serine/threonine phosphatase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase." [EC:3.1.3.16]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0005964
name: phosphorylase kinase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a." [EC:2.7.11.19]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005965
name: protein farnesyltransferase complex
namespace: cellular_component
def: "A protein complex that possesses protein farnesyltransferase activity." [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005966
name: cyclic-nucleotide phosphodiesterase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-]
synonym: "photoreceptor cyclic-nucleotide phosphodiesterase complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0005967
name: mitochondrial pyruvate dehydrogenase complex
namespace: cellular_component
def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase." [GOC:mtg_sensu, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
synonym: "pyruvate dehydrogenase complex (lipoamide)" BROAD []
is_a: GO:0044429 ! mitochondrial part
is_a: GO:0045254 ! pyruvate dehydrogenase complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0005968
name: Rab-protein geranylgeranyltransferase complex
namespace: cellular_component
def: "A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl moiety from geranylgeranyl pyrophosphate to a Rab protein." [GOC:jl, PMID:11886217]
synonym: "GGTase-II complex" EXACT []
synonym: "Rab geranylgeranyltransferase complex" EXACT []
synonym: "RAB-protein geranylgeranyltransferase complex" EXACT []
synonym: "RabGGTase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005969
name: serine-pyruvate aminotransferase complex
namespace: cellular_component
alt_id: GO:0005970
def: "An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate." [EC:2.6.1.51]
synonym: "serine-pyruvate aminotransferase, type 1 complex" NARROW []
synonym: "serine-pyruvate aminotransferase, type 2B complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005971
name: ribonucleoside-diphosphate reductase complex
namespace: cellular_component
def: "An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate and thioredoxin disulfide from ribonucleoside diphosphate and thioredoxin." [BRENDA:1.17.4.1]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0005972
name: fibrinogen alpha chain
namespace: cellular_component
alt_id: GO:0008005
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
consider: GO:0005577

[Term]
id: GO:0005973
name: fibrinogen beta chain
namespace: cellular_component
alt_id: GO:0008006
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
consider: GO:0005577

[Term]
id: GO:0005974
name: fibrinogen gamma chain
namespace: cellular_component
alt_id: GO:0008007
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
consider: GO:0005577

[Term]
id: GO:0005975
name: carbohydrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: gosubset_prok
synonym: "carbohydrate metabolism" EXACT []
xref: Reactome:448487 "Metabolism of carbohydrates"
xref: Reactome:469617 "Metabolism of carbohydrates"
xref: Reactome:487336 "Metabolism of carbohydrates"
xref: Reactome:507287 "Metabolism of carbohydrates"
xref: Reactome:517301 "Metabolism of carbohydrates"
xref: Reactome:526186 "Metabolism of carbohydrates"
xref: Reactome:531076 "Metabolism of carbohydrates"
xref: Reactome:536449 "Metabolism of carbohydrates"
xref: Reactome:542153 "Metabolism of carbohydrates"
xref: Reactome:547511 "Metabolism of carbohydrates"
xref: Reactome:552109 "Metabolism of carbohydrates"
xref: Reactome:557702 "Metabolism of carbohydrates"
xref: Reactome:568311 "Metabolism of carbohydrates"
xref: Reactome:581513 "Metabolism of carbohydrates"
xref: Reactome:585745 "Metabolism of carbohydrates"
xref: Reactome:592407 "Metabolism of carbohydrates"
xref: Reactome:595291 "Metabolism of carbohydrates"
xref: Reactome:597267 "Metabolism of carbohydrates"
xref: Reactome:598076 "Metabolism of carbohydrates"
xref: Reactome:599604 "Metabolism of carbohydrates"
xref: Reactome:600550 "Metabolism of carbohydrates"
xref: Reactome:602409 "Metabolism of carbohydrates"
xref: Reactome:71387 "Metabolism of carbohydrates"
xref: Wikipedia:Carbohydrate_metabolism
is_a: GO:0044238 ! primary metabolic process

[Term]
id: GO:0005976
name: polysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polysaccharides, a polymer of more than 20 monosaccharide residues joined by glycosidic linkages." [ISBN:0198547684]
subset: goslim_pir
subset: gosubset_prok
synonym: "glycan metabolic process" EXACT []
synonym: "glycan metabolism" EXACT []
synonym: "polysaccharide metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0005977
name: glycogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycogen metabolism" EXACT []
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0006073 ! cellular glucan metabolic process
is_a: GO:0006112 ! energy reserve metabolic process

[Term]
id: GO:0005978
name: glycogen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycogen anabolism" EXACT []
synonym: "glycogen biosynthesis" EXACT []
synonym: "glycogen formation" EXACT []
synonym: "glycogen synthesis" EXACT []
xref: MetaCyc:GLYCOGENSYNTH-PWY
xref: Reactome:448794 "Glycogen synthesis"
xref: Reactome:469910 "Glycogen synthesis"
xref: Reactome:487616 "Glycogen synthesis"
xref: Reactome:507571 "Glycogen synthesis"
xref: Reactome:517545 "Glycogen synthesis"
xref: Reactome:526412 "Glycogen synthesis"
xref: Reactome:531235 "Glycogen synthesis"
xref: Reactome:536604 "Glycogen synthesis"
xref: Reactome:542330 "Glycogen synthesis"
xref: Reactome:547668 "Glycogen synthesis"
xref: Reactome:552255 "Glycogen synthesis"
xref: Reactome:557874 "Glycogen synthesis"
xref: Reactome:568472 "Glycogen synthesis"
xref: Reactome:581683 "Glycogen synthesis"
xref: Reactome:585831 "Glycogen synthesis"
xref: Reactome:592590 "Glycogen synthesis"
xref: Reactome:599704 "Glycogen synthesis"
xref: Reactome:600611 "Glycogen synthesis"
xref: Reactome:602513 "Glycogen synthesis"
xref: Reactome:70302 "Glycogen synthesis"
is_a: GO:0005977 ! glycogen metabolic process
is_a: GO:0009250 ! glucan biosynthetic process

[Term]
id: GO:0005979
name: regulation of glycogen biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of glycogen anabolism" EXACT []
synonym: "regulation of glycogen biosynthesis" EXACT []
synonym: "regulation of glycogen formation" EXACT []
synonym: "regulation of glycogen synthesis" EXACT []
is_a: GO:0010962 ! regulation of glucan biosynthetic process
is_a: GO:0070873 ! regulation of glycogen metabolic process
relationship: regulates GO:0005978 ! glycogen biosynthetic process

[Term]
id: GO:0005980
name: glycogen catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycogen breakdown" EXACT []
synonym: "glycogen catabolism" EXACT []
synonym: "glycogen degradation" EXACT []
xref: MetaCyc:GLYCOCAT-PWY
xref: Reactome:449007 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:470119 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:487821 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:507782 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:517702 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:526536 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:531333 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:536715 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:542447 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:547792 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:552355 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:557964 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:568603 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:581807 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:585905 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:592720 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:599739 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:600642 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:602548 "Glycogen breakdown (glycogenolysis)"
xref: Reactome:70221 "Glycogen breakdown (glycogenolysis)"
is_a: GO:0005977 ! glycogen metabolic process
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process

[Term]
id: GO:0005981
name: regulation of glycogen catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of glycogen breakdown" EXACT []
synonym: "regulation of glycogen catabolism" EXACT []
synonym: "regulation of glycogen degradation" EXACT []
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
is_a: GO:0070873 ! regulation of glycogen metabolic process
relationship: regulates GO:0005980 ! glycogen catabolic process

[Term]
id: GO:0005982
name: starch metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "starch metabolism" EXACT []
is_a: GO:0006073 ! cellular glucan metabolic process

[Term]
id: GO:0005983
name: starch catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants." [GOC:ai]
subset: gosubset_prok
synonym: "starch breakdown" EXACT []
synonym: "starch catabolism" EXACT []
synonym: "starch degradation" EXACT []
xref: MetaCyc:PWY-842
is_a: GO:0005982 ! starch metabolic process
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process

[Term]
id: GO:0005984
name: disaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units." [GOC:jl, ISBN:01928006X]
subset: gosubset_prok
synonym: "disaccharide metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0005985
name: sucrose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators]
subset: gosubset_prok
synonym: "sucrose metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process
is_a: GO:0016137 ! glycoside metabolic process

[Term]
id: GO:0005986
name: sucrose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators]
subset: gosubset_prok
synonym: "sucrose anabolism" EXACT []
synonym: "sucrose biosynthesis" EXACT []
synonym: "sucrose formation" EXACT []
synonym: "sucrose synthesis" EXACT []
xref: MetaCyc:SUCSYN-PWY
is_a: GO:0005985 ! sucrose metabolic process
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0046351 ! disaccharide biosynthetic process

[Term]
id: GO:0005987
name: sucrose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators]
subset: gosubset_prok
synonym: "sucrose breakdown" EXACT []
synonym: "sucrose catabolism" EXACT []
synonym: "sucrose degradation" EXACT []
is_a: GO:0005985 ! sucrose metabolic process
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0046352 ! disaccharide catabolic process

[Term]
id: GO:0005988
name: lactose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators]
subset: gosubset_prok
synonym: "lactose metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process

[Term]
id: GO:0005989
name: lactose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators]
subset: gosubset_prok
synonym: "lactose anabolism" EXACT []
synonym: "lactose biosynthesis" EXACT []
synonym: "lactose formation" EXACT []
synonym: "lactose synthesis" EXACT []
is_a: GO:0005988 ! lactose metabolic process
is_a: GO:0046351 ! disaccharide biosynthetic process

[Term]
id: GO:0005990
name: lactose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators]
subset: gosubset_prok
synonym: "lactose breakdown" EXACT []
synonym: "lactose catabolism" EXACT []
synonym: "lactose degradation" EXACT []
is_a: GO:0005988 ! lactose metabolic process
is_a: GO:0046352 ! disaccharide catabolic process

[Term]
id: GO:0005991
name: trehalose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]
subset: gosubset_prok
synonym: "mycose metabolic process" EXACT []
synonym: "mycose metabolism" EXACT []
synonym: "mykose metabolic process" EXACT []
synonym: "mykose metabolism" EXACT []
synonym: "trehalose metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process
is_a: GO:0016137 ! glycoside metabolic process

[Term]
id: GO:0005992
name: trehalose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]
subset: gosubset_prok
synonym: "mycose biosynthesis" EXACT []
synonym: "mycose biosynthetic process" EXACT []
synonym: "mykose biosynthesis" EXACT []
synonym: "mykose biosynthetic process" EXACT []
synonym: "trehalose anabolism" EXACT []
synonym: "trehalose biosynthesis" EXACT []
synonym: "trehalose formation" EXACT []
synonym: "trehalose synthesis" EXACT []
xref: MetaCyc:PWY-881
xref: MetaCyc:TREHALOSESYN-PWY
xref: MetaCyc:TRESYN-PWY
is_a: GO:0005991 ! trehalose metabolic process
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0046351 ! disaccharide biosynthetic process

[Term]
id: GO:0005993
name: trehalose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819]
subset: gosubset_prok
synonym: "mycose catabolic process" EXACT []
synonym: "mycose catabolism" EXACT []
synonym: "mykose catabolic process" EXACT []
synonym: "mykose catabolism" EXACT []
synonym: "trehalose breakdown" EXACT []
synonym: "trehalose catabolism" EXACT []
synonym: "trehalose degradation" EXACT []
xref: MetaCyc:TREDEGLOW-PWY
is_a: GO:0005991 ! trehalose metabolic process
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0046352 ! disaccharide catabolic process

[Term]
id: GO:0005994
name: melibiose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684]
subset: gosubset_prok
synonym: "melibiose metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process

[Term]
id: GO:0005995
name: melibiose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684]
subset: gosubset_prok
synonym: "melibiose breakdown" EXACT []
synonym: "melibiose catabolism" EXACT []
synonym: "melibiose degradation" EXACT []
is_a: GO:0005994 ! melibiose metabolic process
is_a: GO:0046352 ! disaccharide catabolic process

[Term]
id: GO:0005996
name: monosaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "monosaccharide metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0005997
name: xylulose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684]
subset: gosubset_prok
synonym: "xylulose metabolism" EXACT []
is_a: GO:0019321 ! pentose metabolic process

[Term]
id: GO:0005998
name: xylulose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684]
subset: gosubset_prok
synonym: "xylulose breakdown" EXACT []
synonym: "xylulose catabolism" EXACT []
synonym: "xylulose degradation" EXACT []
xref: MetaCyc:XYLCAT-PWY
is_a: GO:0005997 ! xylulose metabolic process
is_a: GO:0019323 ! pentose catabolic process

[Term]
id: GO:0005999
name: xylulose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684]
subset: gosubset_prok
synonym: "xylulose anabolism" EXACT []
synonym: "xylulose biosynthesis" EXACT []
synonym: "xylulose formation" EXACT []
synonym: "xylulose synthesis" EXACT []
xref: Reactome:163754 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:449006 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:470118 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:487820 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:507781 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:517701 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:526535 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:531332 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:536714 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:542446 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:547791 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:552356 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:557963 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:568602 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:581806 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:585907 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:592719 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:595461 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:597389 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:598172 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:599738 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:600641 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
xref: Reactome:602549 "Insulin effects increased synthesis of Xylulose-5-Phosphate"
is_a: GO:0005997 ! xylulose metabolic process
is_a: GO:0019322 ! pentose biosynthetic process

[Term]
id: GO:0006000
name: fructose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "fructose metabolism" EXACT []
xref: Wikipedia:Fructose
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0006001
name: fructose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose." [GOC:ai]
subset: gosubset_prok
synonym: "fructose breakdown" EXACT []
synonym: "fructose catabolism" EXACT []
synonym: "fructose degradation" EXACT []
xref: Reactome:448870 "Fructose catabolism"
xref: Reactome:469987 "Fructose catabolism"
xref: Reactome:507644 "Fructose catabolism"
xref: Reactome:517607 "Fructose catabolism"
xref: Reactome:542366 "Fructose catabolism"
xref: Reactome:581736 "Fructose catabolism"
xref: Reactome:597364 "Fructose catabolism"
xref: Reactome:70350 "Fructose catabolism"
is_a: GO:0006000 ! fructose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0006002
name: fructose 6-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "fructose 6-phosphate metabolism" EXACT []
is_a: GO:0006000 ! fructose metabolic process

[Term]
id: GO:0006003
name: fructose 2,6-bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "fructose 2,6-bisphosphate metabolism" EXACT []
is_a: GO:0006000 ! fructose metabolic process

[Term]
id: GO:0006004
name: fucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "fucose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0006005
name: L-fucose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-fucose (6-deoxy-L-galactose)." [GOC:jl]
subset: gosubset_prok
synonym: "L-fucose anabolism" EXACT []
synonym: "L-fucose biosynthesis" EXACT []
synonym: "L-fucose formation" EXACT []
synonym: "L-fucose synthesis" EXACT []
is_a: GO:0042353 ! fucose biosynthetic process
is_a: GO:0042354 ! L-fucose metabolic process

[Term]
id: GO:0006006
name: glucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cellular glucose metabolic process" EXACT [GOC:vw]
synonym: "glucose metabolism" EXACT []
xref: Reactome:448486 "Glucose metabolism"
xref: Reactome:469616 "Glucose metabolism"
xref: Reactome:487335 "Glucose metabolism"
xref: Reactome:507286 "Glucose metabolism"
xref: Reactome:517300 "Glucose metabolism"
xref: Reactome:526185 "Glucose metabolism"
xref: Reactome:531075 "Glucose metabolism"
xref: Reactome:536448 "Glucose metabolism"
xref: Reactome:542152 "Glucose metabolism"
xref: Reactome:547510 "Glucose metabolism"
xref: Reactome:552108 "Glucose metabolism"
xref: Reactome:557701 "Glucose metabolism"
xref: Reactome:568310 "Glucose metabolism"
xref: Reactome:581512 "Glucose metabolism"
xref: Reactome:585744 "Glucose metabolism"
xref: Reactome:592406 "Glucose metabolism"
xref: Reactome:595290 "Glucose metabolism"
xref: Reactome:597266 "Glucose metabolism"
xref: Reactome:598075 "Glucose metabolism"
xref: Reactome:599603 "Glucose metabolism"
xref: Reactome:600549 "Glucose metabolism"
xref: Reactome:602408 "Glucose metabolism"
xref: Reactome:70326 "Glucose metabolism"
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0006007
name: glucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai]
subset: gosubset_prok
synonym: "glucose breakdown" EXACT []
synonym: "glucose catabolism" EXACT []
synonym: "glucose degradation" EXACT []
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0006008
name: glucose 1-phosphate utilization
namespace: biological_process
subset: gosubset_prok
is_a: GO:0019255 ! glucose 1-phosphate metabolic process

[Term]
id: GO:0006009
name: glucose 1-phosphate phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into glucose 1-phosphate to produce glucose bisphosphate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0019255 ! glucose 1-phosphate metabolic process
is_a: GO:0046835 ! carbohydrate phosphorylation

[Term]
id: GO:0006010
name: glucose 6-phosphate utilization
namespace: biological_process
subset: gosubset_prok
is_a: GO:0051156 ! glucose 6-phosphate metabolic process

[Term]
id: GO:0006011
name: UDP-glucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-glucose metabolism" EXACT []
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0006012
name: galactose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "galactose metabolism" EXACT []
xref: MetaCyc:GALACTMETAB-PWY
xref: Wikipedia:Galactose
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0006013
name: mannose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "mannose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0006014
name: D-ribose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-ribose metabolism" EXACT []
is_a: GO:0019321 ! pentose metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0006015
name: 5-phosphoribose 1-diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate." [GOC:ai]
subset: gosubset_prok
synonym: "5-phosphoribose 1-diphosphate anabolism" EXACT []
synonym: "5-phosphoribose 1-diphosphate biosynthesis" EXACT []
synonym: "5-phosphoribose 1-diphosphate formation" EXACT []
synonym: "5-phosphoribose 1-diphosphate synthesis" EXACT []
synonym: "5-phosphoribosyl-1-pyrophosphate biosynthesis" EXACT []
synonym: "5-phosphoribosyl-1-pyrophosphate biosynthetic process" EXACT []
synonym: "PRPP biosynthetic process" EXACT []
xref: MetaCyc:PWY0-661
xref: Reactome:449010 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:470122 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:487824 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:507784 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:517704 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:526539 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:531335 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:536717 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:542449 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:547794 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:552358 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:557966 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:568605 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:581809 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:585909 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:592723 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:595463 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:597391 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:598173 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:599741 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:600644 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:602552 "5-Phosphoribose 1-diphosphate biosynthesis"
xref: Reactome:73843 "5-Phosphoribose 1-diphosphate biosynthesis"
is_a: GO:0046390 ! ribose phosphate biosynthetic process
is_a: GO:0046391 ! 5-phosphoribose 1-diphosphate metabolic process

[Term]
id: GO:0006016
name: 2-deoxyribose 1-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "2-deoxyribose 1-phosphate anabolism" EXACT []
synonym: "2-deoxyribose 1-phosphate biosynthesis" EXACT []
synonym: "2-deoxyribose 1-phosphate formation" EXACT []
synonym: "2-deoxyribose 1-phosphate synthesis" EXACT []
is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process
is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process

[Term]
id: GO:0006017
name: deoxyribose 1,5-bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose." [GOC:ai]
subset: gosubset_prok
synonym: "deoxyribose 1,5-bisphosphate anabolism" EXACT []
synonym: "deoxyribose 1,5-bisphosphate biosynthesis" EXACT []
synonym: "deoxyribose 1,5-bisphosphate formation" EXACT []
synonym: "deoxyribose 1,5-bisphosphate synthesis" EXACT []
is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process
is_a: GO:0046387 ! deoxyribose 1,5-bisphosphate metabolic process

[Term]
id: GO:0006018
name: 2-deoxyribose 1-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [GOC:ai]
subset: gosubset_prok
synonym: "2-deoxyribose 1-phosphate breakdown" EXACT []
synonym: "2-deoxyribose 1-phosphate catabolism" EXACT []
synonym: "2-deoxyribose 1-phosphate degradation" EXACT []
synonym: "deoxyribose 1-phosphate catabolic process" EXACT [GOC:mah]
is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process
is_a: GO:0046386 ! deoxyribose phosphate catabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0006019
name: deoxyribose 5-phosphate phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into deoxyribose 5-phosphate to produce deoxyribose bisphosphate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0046389 ! deoxyribose 5-phosphate metabolic process
is_a: GO:0046835 ! carbohydrate phosphorylation

[Term]
id: GO:0006020
name: inositol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ChEBI:24848, ISBN:0198547684]
subset: gosubset_prok
synonym: "inositol metabolism" EXACT []
synonym: "myo-inositol metabolic process" NARROW []
synonym: "myo-inositol metabolism" NARROW []
synonym: "vitamin Bh metabolic process" EXACT []
synonym: "vitamin Bh metabolism" EXACT []
xref: Wikipedia:Inositol
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0006021
name: inositol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ChEBI:24848, ISBN:0198547684]
subset: gosubset_prok
synonym: "inositol anabolism" EXACT []
synonym: "inositol biosynthesis" EXACT []
synonym: "inositol formation" EXACT []
synonym: "inositol synthesis" EXACT []
synonym: "myo-inositol biosynthesis" NARROW []
synonym: "myo-inositol biosynthetic process" NARROW []
synonym: "vitamin Bh biosynthesis" EXACT []
synonym: "vitamin Bh biosynthetic process" EXACT []
is_a: GO:0006020 ! inositol metabolic process
is_a: GO:0034637 ! cellular carbohydrate biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process

[Term]
id: GO:0006022
name: aminoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aminoglycan metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0009308 ! amine metabolic process

[Term]
id: GO:0006023
name: aminoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aminoglycan anabolism" EXACT []
synonym: "aminoglycan biosynthesis" EXACT []
synonym: "aminoglycan formation" EXACT []
synonym: "aminoglycan synthesis" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0006022 ! aminoglycan metabolic process

[Term]
id: GO:0006024
name: glycosaminoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]
subset: gosubset_prok
synonym: "glycosaminoglycan anabolism" EXACT []
synonym: "glycosaminoglycan biosynthesis" EXACT []
synonym: "glycosaminoglycan formation" EXACT []
synonym: "glycosaminoglycan synthesis" EXACT []
is_a: GO:0006023 ! aminoglycan biosynthetic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0006025
name: galactosaminoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai]
subset: gosubset_prok
synonym: "galactosaminoglycan anabolism" EXACT []
synonym: "galactosaminoglycan biosynthesis" EXACT []
synonym: "galactosaminoglycan formation" EXACT []
synonym: "galactosaminoglycan synthesis" EXACT []
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0046350 ! galactosaminoglycan metabolic process

[Term]
id: GO:0006026
name: aminoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aminoglycan breakdown" EXACT []
synonym: "aminoglycan catabolism" EXACT []
synonym: "aminoglycan degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0006022 ! aminoglycan metabolic process

[Term]
id: GO:0006027
name: glycosaminoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981]
subset: gosubset_prok
synonym: "glycosaminoglycan breakdown" EXACT []
synonym: "glycosaminoglycan catabolism" EXACT []
synonym: "glycosaminoglycan degradation" EXACT []
is_a: GO:0006026 ! aminoglycan catabolic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0006028
name: galactosaminoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai]
subset: gosubset_prok
synonym: "galactosaminoglycan breakdown" EXACT []
synonym: "galactosaminoglycan catabolism" EXACT []
synonym: "galactosaminoglycan degradation" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0046350 ! galactosaminoglycan metabolic process

[Term]
id: GO:0006029
name: proteoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "proteoglycan metabolism" EXACT []
synonym: "proteoglycan sulfate transfer" NARROW []
is_a: GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:0006030
name: chitin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "beta-1,4-linked N-acetylglucosamine metabolic process" EXACT []
synonym: "beta-1,4-linked N-acetylglucosamine metabolism" EXACT []
synonym: "chitin metabolism" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process

[Term]
id: GO:0006031
name: chitin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "beta-1,4-linked N-acetylglucosamine biosynthesis" EXACT []
synonym: "beta-1,4-linked N-acetylglucosamine biosynthetic process" EXACT []
synonym: "chitin anabolism" EXACT []
synonym: "chitin biosynthesis" EXACT []
synonym: "chitin formation" EXACT []
synonym: "chitin synthesis" EXACT []
is_a: GO:0006023 ! aminoglycan biosynthetic process
is_a: GO:0006030 ! chitin metabolic process

[Term]
id: GO:0006032
name: chitin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "beta-1,4-linked N-acetylglucosamine catabolic process" EXACT []
synonym: "beta-1,4-linked N-acetylglucosamine catabolism" EXACT []
synonym: "chitin breakdown" EXACT []
synonym: "chitin catabolism" EXACT []
synonym: "chitin degradation" EXACT []
is_a: GO:0006026 ! aminoglycan catabolic process
is_a: GO:0006030 ! chitin metabolic process

[Term]
id: GO:0006033
name: chitin localization
namespace: biological_process
def: "A process by which chitin is transported to, or maintained in, a specific location." [GOC:ai]
subset: gosubset_prok
synonym: "establishment and maintenance of chitin localization" EXACT []
is_a: GO:0033037 ! polysaccharide localization

[Term]
id: GO:0006034
name: cuticle chitin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cuticle chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai]
synonym: "cuticle chitin metabolism" EXACT []
is_a: GO:0006030 ! chitin metabolic process

[Term]
id: GO:0006035
name: cuticle chitin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cuticle chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai]
synonym: "cuticle chitin anabolism" EXACT []
synonym: "cuticle chitin biosynthesis" EXACT []
synonym: "cuticle chitin formation" EXACT []
synonym: "cuticle chitin synthesis" EXACT []
is_a: GO:0006031 ! chitin biosynthetic process
is_a: GO:0006034 ! cuticle chitin metabolic process
relationship: part_of GO:0042335 ! cuticle development

[Term]
id: GO:0006036
name: cuticle chitin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai]
synonym: "cuticle chitin breakdown" EXACT []
synonym: "cuticle chitin catabolism" EXACT []
synonym: "cuticle chitin degradation" EXACT []
is_a: GO:0006032 ! chitin catabolic process
is_a: GO:0006034 ! cuticle chitin metabolic process

[Term]
id: GO:0006037
name: cell wall chitin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai]
subset: gosubset_prok
synonym: "cell wall chitin metabolism" EXACT []
is_a: GO:0006030 ! chitin metabolic process
is_a: GO:0010383 ! cell wall polysaccharide metabolic process

[Term]
id: GO:0006038
name: cell wall chitin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai]
synonym: "cell wall chitin anabolism" EXACT []
synonym: "cell wall chitin biosynthesis" EXACT []
synonym: "cell wall chitin formation" EXACT []
synonym: "cell wall chitin synthesis" EXACT []
is_a: GO:0006031 ! chitin biosynthetic process
is_a: GO:0006037 ! cell wall chitin metabolic process
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process

[Term]
id: GO:0006039
name: cell wall chitin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai]
subset: gosubset_prok
synonym: "cell wall chitin breakdown" EXACT []
synonym: "cell wall chitin catabolism" EXACT []
synonym: "cell wall chitin degradation" EXACT []
is_a: GO:0006032 ! chitin catabolic process
is_a: GO:0006037 ! cell wall chitin metabolic process
is_a: GO:0016998 ! cell wall macromolecule catabolic process

[Term]
id: GO:0006040
name: amino sugar metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "amino sugar metabolism" EXACT []
synonym: "aminosaccharide metabolic process" EXACT []
synonym: "aminosaccharide metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process

[Term]
id: GO:0006041
name: glucosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "chitosamine metabolic process" EXACT []
synonym: "chitosamine metabolism" EXACT []
synonym: "glucosamine metabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process

[Term]
id: GO:0006042
name: glucosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "chitosamine biosynthesis" EXACT []
synonym: "chitosamine biosynthetic process" EXACT []
synonym: "glucosamine anabolism" EXACT []
synonym: "glucosamine biosynthesis" EXACT []
synonym: "glucosamine formation" EXACT []
synonym: "glucosamine synthesis" EXACT []
is_a: GO:0006041 ! glucosamine metabolic process
is_a: GO:0046349 ! amino sugar biosynthetic process

[Term]
id: GO:0006043
name: glucosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "chitosamine catabolic process" EXACT []
synonym: "chitosamine catabolism" EXACT []
synonym: "glucosamine breakdown" EXACT []
synonym: "glucosamine catabolism" EXACT []
synonym: "glucosamine degradation" EXACT []
xref: MetaCyc:GLUAMCAT-PWY
is_a: GO:0006041 ! glucosamine metabolic process
is_a: GO:0046348 ! amino sugar catabolic process

[Term]
id: GO:0006044
name: N-acetylglucosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "N-acetylglucosamine metabolism" EXACT []
is_a: GO:0006041 ! glucosamine metabolic process

[Term]
id: GO:0006045
name: N-acetylglucosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "N-acetylglucosamine anabolism" EXACT []
synonym: "N-acetylglucosamine biosynthesis" EXACT []
synonym: "N-acetylglucosamine formation" EXACT []
synonym: "N-acetylglucosamine synthesis" EXACT []
is_a: GO:0006042 ! glucosamine biosynthetic process
is_a: GO:0006044 ! N-acetylglucosamine metabolic process

[Term]
id: GO:0006046
name: N-acetylglucosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "N-acetylglucosamine breakdown" EXACT []
synonym: "N-acetylglucosamine catabolism" EXACT []
synonym: "N-acetylglucosamine degradation" EXACT []
is_a: GO:0006043 ! glucosamine catabolic process
is_a: GO:0006044 ! N-acetylglucosamine metabolic process

[Term]
id: GO:0006047
name: UDP-N-acetylglucosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-N-acetylglucosamine metabolism" EXACT []
is_a: GO:0006044 ! N-acetylglucosamine metabolic process
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0006048
name: UDP-N-acetylglucosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-GlcNAc biosynthesis" EXACT []
synonym: "UDP-GlcNAc biosynthetic process" EXACT []
synonym: "UDP-N-acetylglucosamine anabolism" EXACT []
synonym: "UDP-N-acetylglucosamine biosynthesis" EXACT []
synonym: "UDP-N-acetylglucosamine formation" EXACT []
synonym: "UDP-N-acetylglucosamine synthesis" EXACT []
xref: MetaCyc:UDPNAGSYN-PWY
is_a: GO:0006045 ! N-acetylglucosamine biosynthetic process
is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process

[Term]
id: GO:0006049
name: UDP-N-acetylglucosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-N-acetylglucosamine breakdown" EXACT []
synonym: "UDP-N-acetylglucosamine catabolism" EXACT []
synonym: "UDP-N-acetylglucosamine degradation" EXACT []
is_a: GO:0006046 ! N-acetylglucosamine catabolic process
is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process

[Term]
id: GO:0006050
name: mannosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "mannosamine metabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process

[Term]
id: GO:0006051
name: N-acetylmannosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "N-acetylmannosamine metabolism" EXACT []
is_a: GO:0006050 ! mannosamine metabolic process

[Term]
id: GO:0006052
name: N-acetylmannosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "N-acetylmannosamine anabolism" EXACT []
synonym: "N-acetylmannosamine biosynthesis" EXACT []
synonym: "N-acetylmannosamine formation" EXACT []
synonym: "N-acetylmannosamine synthesis" EXACT []
is_a: GO:0006051 ! N-acetylmannosamine metabolic process
is_a: GO:0046347 ! mannosamine biosynthetic process

[Term]
id: GO:0006053
name: N-acetylmannosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "N-acetylmannosamine breakdown" EXACT []
synonym: "N-acetylmannosamine catabolism" EXACT []
synonym: "N-acetylmannosamine degradation" EXACT []
is_a: GO:0006051 ! N-acetylmannosamine metabolic process
is_a: GO:0046346 ! mannosamine catabolic process

[Term]
id: GO:0006054
name: N-acetylneuraminate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "N-acetylneuraminate metabolism" EXACT []
synonym: "sialic acid metabolic process" BROAD []
synonym: "sialic acid metabolism" BROAD []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0006055
name: CMP-N-acetylneuraminate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai]
subset: gosubset_prok
synonym: "CMP-N-acetylneuraminate anabolism" EXACT []
synonym: "CMP-N-acetylneuraminate biosynthesis" EXACT []
synonym: "CMP-N-acetylneuraminate formation" EXACT []
synonym: "CMP-N-acetylneuraminate synthesis" EXACT []
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046380 ! N-acetylneuraminate biosynthetic process
is_a: GO:0046381 ! CMP-N-acetylneuraminate metabolic process

[Term]
id: GO:0006056
name: mannoprotein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannoproteins, any protein that contains covalently bound mannose residues other than as a moiety of nucleic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "mannoprotein metabolism" EXACT []
is_a: GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:0006057
name: mannoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannoproteins, any protein that contains covalently bound mannose residues other than as a moiety of nucleic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "mannoprotein anabolism" EXACT []
synonym: "mannoprotein biosynthesis" EXACT []
synonym: "mannoprotein formation" EXACT []
synonym: "mannoprotein synthesis" EXACT []
is_a: GO:0006056 ! mannoprotein metabolic process
is_a: GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0006058
name: mannoprotein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannoproteins, any protein that contains covalently bound mannose residues other than as a moiety of nucleic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "mannoprotein breakdown" EXACT []
synonym: "mannoprotein catabolism" EXACT []
synonym: "mannoprotein degradation" EXACT []
is_a: GO:0006056 ! mannoprotein metabolic process
is_a: GO:0006516 ! glycoprotein catabolic process
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process

[Term]
id: GO:0006059
name: hexitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "hexitol metabolism" EXACT []
synonym: "sugar alcohol (hexitol) metabolic process" EXACT []
synonym: "sugar alcohol (hexitol) metabolism" EXACT []
is_a: GO:0019400 ! alditol metabolic process

[Term]
id: GO:0006060
name: sorbitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sorbitol metabolism" EXACT []
xref: MetaCyc:P461-PWY
is_a: GO:0006059 ! hexitol metabolic process

[Term]
id: GO:0006061
name: sorbitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sorbitol anabolism" EXACT []
synonym: "sorbitol biosynthesis" EXACT []
synonym: "sorbitol formation" EXACT []
synonym: "sorbitol synthesis" EXACT []
is_a: GO:0006060 ! sorbitol metabolic process
is_a: GO:0019406 ! hexitol biosynthetic process

[Term]
id: GO:0006062
name: sorbitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sorbitol breakdown" EXACT []
synonym: "sorbitol catabolism" EXACT []
synonym: "sorbitol degradation" EXACT []
xref: MetaCyc:SORBDEG-PWY
is_a: GO:0006060 ! sorbitol metabolic process
is_a: GO:0019407 ! hexitol catabolic process

[Term]
id: GO:0006063
name: uronic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "uronic acid metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0006064
name: glucuronate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "glucuronate breakdown" EXACT []
synonym: "glucuronate catabolism" EXACT []
synonym: "glucuronate degradation" EXACT []
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0019585 ! glucuronate metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0006065
name: UDP-glucuronate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-glucuronate anabolism" EXACT []
synonym: "UDP-glucuronate biosynthesis" EXACT []
synonym: "UDP-glucuronate formation" EXACT []
synonym: "UDP-glucuronate synthesis" EXACT []
xref: MetaCyc:PWY-4841
xref: Reactome:173599 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:449307 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:470426 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:488106 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:508073 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:517920 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:526748 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:531514 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:536905 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:542651 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:547968 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:552543 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:558168 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:568794 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:581997 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:586043 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:592908 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:597455 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:598222 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:599789 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:600709 "Formation of the active cofactor, UDP-glucuronate"
xref: Reactome:602627 "Formation of the active cofactor, UDP-glucuronate"
is_a: GO:0046398 ! UDP-glucuronate metabolic process
is_a: GO:0046399 ! glucuronate biosynthetic process

[Term]
id: GO:0006066
name: alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [ChEBI:30879, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
synonym: "alcohol metabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0006067
name: ethanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ethanol metabolism" EXACT []
is_a: GO:0034308 ! monohydric alcohol metabolic process

[Term]
id: GO:0006068
name: ethanol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ethanol breakdown" EXACT []
synonym: "ethanol catabolism" EXACT []
synonym: "ethanol degradation" EXACT []
xref: Reactome:448622 "Ethanol catabolism"
xref: Reactome:469750 "Ethanol catabolism"
xref: Reactome:487457 "Ethanol catabolism"
xref: Reactome:507414 "Ethanol catabolism"
xref: Reactome:517416 "Ethanol catabolism"
xref: Reactome:526290 "Ethanol catabolism"
xref: Reactome:531154 "Ethanol catabolism"
xref: Reactome:536525 "Ethanol catabolism"
xref: Reactome:542243 "Ethanol catabolism"
xref: Reactome:547591 "Ethanol catabolism"
xref: Reactome:552203 "Ethanol catabolism"
xref: Reactome:557789 "Ethanol catabolism"
xref: Reactome:568402 "Ethanol catabolism"
xref: Reactome:581604 "Ethanol catabolism"
xref: Reactome:592500 "Ethanol catabolism"
xref: Reactome:595433 "Ethanol catabolism"
xref: Reactome:597323 "Ethanol catabolism"
xref: Reactome:598120 "Ethanol catabolism"
xref: Reactome:599668 "Ethanol catabolism"
xref: Reactome:600623 "Ethanol catabolism"
xref: Reactome:602484 "Ethanol catabolism"
xref: Reactome:71384 "Ethanol catabolism"
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0034310 ! monohydric alcohol catabolic process

[Term]
id: GO:0006069
name: ethanol oxidation
namespace: biological_process
def: "An ethanol metabolic process by which ethanol is converted to acetyl-CoA via acetaldehyde and acetate." [GOC:mah, MetaCyc:PWY66-161, MetaCyc:PWY66-162, MetaCyc:PWY66-21]
subset: gosubset_prok
is_a: GO:0006067 ! ethanol metabolic process

[Term]
id: GO:0006070
name: octanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:go_curators]
subset: gosubset_prok
synonym: "octanol metabolism" EXACT []
is_a: GO:0034308 ! monohydric alcohol metabolic process

[Term]
id: GO:0006071
name: glycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycerol metabolism" EXACT []
xref: MetaCyc:GLYCEROLMETAB-PWY
is_a: GO:0019400 ! alditol metabolic process

[Term]
id: GO:0006072
name: glycerol-3-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycerol-3-phosphate metabolism" EXACT []
is_a: GO:0006071 ! glycerol metabolic process
is_a: GO:0006796 ! phosphate metabolic process
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:0006073
name: cellular glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [ISBN:0198547684]
subset: gosubset_prok
synonym: "cellular glucan metabolism" EXACT []
is_a: GO:0044042 ! glucan metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0006074
name: 1,3-beta-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "1,3-beta-glucan metabolism" EXACT []
synonym: "beta-1,3 glucan metabolic process" EXACT []
synonym: "beta-1,3 glucan metabolism" EXACT []
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0006075
name: 1,3-beta-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds." [GOC:ai]
synonym: "1,3-beta-glucan anabolism" EXACT []
synonym: "1,3-beta-glucan biosynthesis" EXACT []
synonym: "1,3-beta-glucan formation" EXACT []
synonym: "1,3-beta-glucan synthesis" EXACT []
synonym: "beta-1,3 glucan anabolism" EXACT []
synonym: "beta-1,3 glucan biosynthesis" EXACT []
synonym: "beta-1,3 glucan biosynthetic process" EXACT []
synonym: "beta-1,3 glucan formation" EXACT []
synonym: "beta-1,3 glucan synthesis" EXACT []
is_a: GO:0006074 ! 1,3-beta-glucan metabolic process
is_a: GO:0051274 ! beta-glucan biosynthetic process

[Term]
id: GO:0006076
name: 1,3-beta-glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-1,3 glucans." [GOC:ai]
subset: gosubset_prok
synonym: "1,3-beta-glucan breakdown" EXACT []
synonym: "1,3-beta-glucan catabolism" EXACT []
synonym: "1,3-beta-glucan degradation" EXACT []
synonym: "beta-1,3 glucan breakdown" EXACT []
synonym: "beta-1,3 glucan catabolic process" EXACT []
synonym: "beta-1,3 glucan catabolism" EXACT []
synonym: "beta-1,3 glucan degradation" EXACT []
is_a: GO:0006074 ! 1,3-beta-glucan metabolic process
is_a: GO:0051275 ! beta-glucan catabolic process

[Term]
id: GO:0006077
name: 1,6-beta-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-1,6 glucans, compounds composed of glucose residues linked by 1,6-beta-D-glucosidic bonds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "1,6-beta-glucan metabolism" EXACT []
synonym: "beta-1,6 glucan metabolic process" EXACT []
synonym: "beta-1,6 glucan metabolism" EXACT []
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0006078
name: 1,6-beta-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-1,6 glucans." [GOC:ai]
synonym: "1,6-beta-glucan anabolism" EXACT []
synonym: "1,6-beta-glucan biosynthesis" EXACT []
synonym: "1,6-beta-glucan formation" EXACT []
synonym: "1,6-beta-glucan synthesis" EXACT []
synonym: "beta-1,6 glucan anabolism" EXACT []
synonym: "beta-1,6 glucan biosynthesis" EXACT []
synonym: "beta-1,6 glucan biosynthetic process" EXACT []
synonym: "beta-1,6 glucan formation" EXACT []
synonym: "beta-1,6 glucan synthesis" EXACT []
is_a: GO:0006077 ! 1,6-beta-glucan metabolic process
is_a: GO:0051274 ! beta-glucan biosynthetic process

[Term]
id: GO:0006079
name: 1,6-beta-glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-1,6 glucans." [GOC:ai]
subset: gosubset_prok
synonym: "1,6-beta-glucan breakdown" EXACT []
synonym: "1,6-beta-glucan catabolism" EXACT []
synonym: "1,6-beta-glucan degradation" EXACT []
synonym: "beta-1,6 glucan breakdown" EXACT []
synonym: "beta-1,6 glucan catabolic process" EXACT []
synonym: "beta-1,6 glucan catabolism" EXACT []
synonym: "beta-1,6 glucan degradation" EXACT []
is_a: GO:0006077 ! 1,6-beta-glucan metabolic process
is_a: GO:0051275 ! beta-glucan catabolic process

[Term]
id: GO:0006080
name: substituted mannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a mannan backbone composed of D-mannose unites, substituted with D-glucose and/or D-galactose units." [GOC:tair_curators]
subset: gosubset_prok
synonym: "substituted mannan metabolism" EXACT []
is_a: GO:0010412 ! mannan metabolic process

[Term]
id: GO:0006081
name: cellular aldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
synonym: "aldehyde metabolism" EXACT []
synonym: "alkanal metabolic process" EXACT []
synonym: "alkanal metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006082
name: organic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
synonym: "organic acid metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0006083
name: acetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetate, the anion of acetic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "acetate metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0006084
name: acetyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684]
subset: gosubset_prok
synonym: "acetyl coenzyme A metabolic process" EXACT []
synonym: "acetyl coenzyme A metabolism" EXACT []
synonym: "acetyl-CoA metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process

[Term]
id: GO:0006085
name: acetyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators]
subset: gosubset_prok
synonym: "acetyl-CoA anabolism" EXACT []
synonym: "acetyl-CoA biosynthesis" EXACT []
synonym: "acetyl-CoA formation" EXACT []
synonym: "acetyl-CoA synthesis" EXACT []
xref: MetaCyc:PWY-5173
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0009108 ! coenzyme biosynthetic process

[Term]
id: GO:0006086
name: acetyl-CoA biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:go_curators, GOC:tb]
subset: gosubset_prok
synonym: "acetyl-CoA anabolism from pyruvate" EXACT []
synonym: "acetyl-CoA formation from pyruvate" EXACT []
synonym: "acetyl-CoA synthesis from pyruvate" EXACT []
synonym: "pyruvate dehydrogenase pathway" EXACT []
xref: MetaCyc:PYRUVDEHYD-PWY
xref: Reactome:448556 "Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase"
xref: Reactome:469685 "Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase"
xref: Reactome:487397 "Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase"
xref: Reactome:507349 "Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase"
xref: Reactome:517359 "Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase"
xref: Reactome:526237 "Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase"
xref: Reactome:536491 "Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase"
xref: Reactome:542196 "Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase"
xref: Reactome:547555 "Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase"
xref: Reactome:552150 "Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase"
xref: Reactome:557741 "Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase"
xref: Reactome:568359 "Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase"
xref: Reactome:581561 "Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase"
xref: Reactome:592449 "Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase"
xref: Reactome:595321 "Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase"
xref: Reactome:71397 "Oxidative decarboxylation of pyruvate to acetyl CoA by pyruvate dehydrogenase"
is_a: GO:0006085 ! acetyl-CoA biosynthetic process
is_a: GO:0006090 ! pyruvate metabolic process

[Term]
id: GO:0006087
name: pyruvate dehydrogenase bypass
namespace: biological_process
subset: gosubset_prok
is_a: GO:0006090 ! pyruvate metabolic process

[Term]
id: GO:0006088
name: acetate to acetyl-CoA
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a function rather than a process.
is_obsolete: true
consider: GO:0003987

[Term]
id: GO:0006089
name: lactate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lactate, the anion of lactic acid." [ISBN:0198547684]
subset: gosubset_prok
synonym: "2-hydroxypropanoate metabolic process" EXACT []
synonym: "2-hydroxypropanoate metabolism" EXACT []
synonym: "alpha-hydroxypropionate metabolic process" EXACT []
synonym: "alpha-hydroxypropionate metabolism" EXACT []
synonym: "lactate metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0006090
name: pyruvate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators]
subset: gosubset_prok
synonym: "pyruvate metabolism" EXACT []
xref: MetaCyc:P41-PWY
xref: Reactome:448485 "Pyruvate metabolism"
xref: Reactome:469615 "Pyruvate metabolism"
xref: Reactome:487334 "Pyruvate metabolism"
xref: Reactome:507285 "Pyruvate metabolism"
xref: Reactome:517299 "Pyruvate metabolism"
xref: Reactome:526184 "Pyruvate metabolism"
xref: Reactome:531074 "Pyruvate metabolism"
xref: Reactome:536447 "Pyruvate metabolism"
xref: Reactome:542151 "Pyruvate metabolism"
xref: Reactome:547509 "Pyruvate metabolism"
xref: Reactome:552107 "Pyruvate metabolism"
xref: Reactome:557742 "Pyruvate metabolism"
xref: Reactome:568309 "Pyruvate metabolism"
xref: Reactome:581511 "Pyruvate metabolism"
xref: Reactome:585743 "Pyruvate metabolism"
xref: Reactome:592450 "Pyruvate metabolism"
xref: Reactome:595289 "Pyruvate metabolism"
xref: Reactome:597265 "Pyruvate metabolism"
xref: Reactome:598074 "Pyruvate metabolism"
xref: Reactome:70268 "Pyruvate metabolism"
xref: Wikipedia:Pyruvic_acid
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0006091
name: generation of precursor metabolites and energy
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "energy pathways" BROAD []
synonym: "intermediary metabolism" RELATED [GOC:mah]
synonym: "metabolic energy generation" RELATED []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006094
name: gluconeogenesis
namespace: biological_process
def: "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "glucose biosynthesis" EXACT []
synonym: "glucose biosynthetic process" EXACT []
xref: MetaCyc:GLUCONEO-PWY
xref: Reactome:448497 "Gluconeogenesis"
xref: Reactome:469627 "Gluconeogenesis"
xref: Reactome:487346 "Gluconeogenesis"
xref: Reactome:507297 "Gluconeogenesis"
xref: Reactome:517311 "Gluconeogenesis"
xref: Reactome:526196 "Gluconeogenesis"
xref: Reactome:531083 "Gluconeogenesis"
xref: Reactome:536456 "Gluconeogenesis"
xref: Reactome:542160 "Gluconeogenesis"
xref: Reactome:547518 "Gluconeogenesis"
xref: Reactome:552111 "Gluconeogenesis"
xref: Reactome:557700 "Gluconeogenesis"
xref: Reactome:568318 "Gluconeogenesis"
xref: Reactome:581520 "Gluconeogenesis"
xref: Reactome:585747 "Gluconeogenesis"
xref: Reactome:592405 "Gluconeogenesis"
xref: Reactome:595293 "Gluconeogenesis"
xref: Reactome:597362 "Gluconeogenesis"
xref: Reactome:598161 "Gluconeogenesis"
xref: Reactome:599602 "Gluconeogenesis"
xref: Reactome:600548 "Gluconeogenesis"
xref: Reactome:602407 "Gluconeogenesis"
xref: Reactome:70263 "Gluconeogenesis"
xref: Wikipedia:Gluconeogenesis
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0006096
name: glycolysis
namespace: biological_process
alt_id: GO:0019641
alt_id: GO:0019642
def: "The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [ISBN:0716720094]
subset: gosubset_prok
synonym: "anaerobic glycolysis" RELATED []
synonym: "Embden-Meyerhof pathway" EXACT []
synonym: "Embden-Meyerhof-Parnas pathway" EXACT []
synonym: "modifed Embden-Meyerhof pathway" RELATED []
xref: MetaCyc:ANAGLYCOLYSIS-PWY
xref: MetaCyc:GLYCOLYSIS
xref: MetaCyc:P341-PWY
xref: MetaCyc:PWY-1042
xref: MetaCyc:PWY-5484
xref: Reactome:448565 "Glycolysis"
xref: Reactome:469694 "Glycolysis"
xref: Reactome:487406 "Glycolysis"
xref: Reactome:507358 "Glycolysis"
xref: Reactome:517369 "Glycolysis"
xref: Reactome:526246 "Glycolysis"
xref: Reactome:531123 "Glycolysis"
xref: Reactome:536495 "Glycolysis"
xref: Reactome:542205 "Glycolysis"
xref: Reactome:547559 "Glycolysis"
xref: Reactome:552161 "Glycolysis"
xref: Reactome:557749 "Glycolysis"
xref: Reactome:568366 "Glycolysis"
xref: Reactome:581568 "Glycolysis"
xref: Reactome:585775 "Glycolysis"
xref: Reactome:592464 "Glycolysis"
xref: Reactome:595331 "Glycolysis"
xref: Reactome:597291 "Glycolysis"
xref: Reactome:598100 "Glycolysis"
xref: Reactome:599643 "Glycolysis"
xref: Reactome:600580 "Glycolysis"
xref: Reactome:602448 "Glycolysis"
xref: Reactome:70171 "Glycolysis"
xref: Wikipedia:Glycolysis
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0006097
name: glyoxylate cycle
namespace: biological_process
def: "A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glyoxylate bypass" EXACT []
xref: MetaCyc:GLYOXYLATE-BYPASS
xref: Wikipedia:Glyoxylate_cycle
is_a: GO:0044262 ! cellular carbohydrate metabolic process
is_a: GO:0046487 ! glyoxylate metabolic process

[Term]
id: GO:0006098
name: pentose-phosphate shunt
namespace: biological_process
def: "The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:PENTOSE-P-PWY]
subset: gosubset_prok
synonym: "hexose monophosphate pathway" EXACT []
synonym: "pentose phosphate pathway" EXACT []
synonym: "pentose phosphate shunt" EXACT []
synonym: "pentose-phosphate pathway" EXACT []
xref: MetaCyc:PENTOSE-P-PWY
xref: Reactome:448609 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:469908 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:487445 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:507402 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:517404 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:526279 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:531147 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:536518 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:542236 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:547586 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:552195 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:557780 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:568393 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:581595 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:585906 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:592491 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:595341 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:597314 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:598171 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:599662 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:600587 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:602475 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Reactome:71336 "Pentose phosphate pathway (hexose monophosphate shunt)"
xref: Wikipedia:Pentose_phosphate_pathway
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0006740 ! NADPH regeneration

[Term]
id: GO:0006099
name: tricarboxylic acid cycle
namespace: biological_process
def: "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "citric acid cycle" EXACT []
synonym: "Krebs cycle" EXACT []
synonym: "TCA cycle" EXACT []
xref: MetaCyc:P105-PWY
xref: MetaCyc:P42-PWY
xref: MetaCyc:TCA
xref: Reactome:448489 "Citric acid cycle (TCA cycle)"
xref: Reactome:469619 "Citric acid cycle (TCA cycle)"
xref: Reactome:487338 "Citric acid cycle (TCA cycle)"
xref: Reactome:507289 "Citric acid cycle (TCA cycle)"
xref: Reactome:517303 "Citric acid cycle (TCA cycle)"
xref: Reactome:526188 "Citric acid cycle (TCA cycle)"
xref: Reactome:531078 "Citric acid cycle (TCA cycle)"
xref: Reactome:536451 "Citric acid cycle (TCA cycle)"
xref: Reactome:542155 "Citric acid cycle (TCA cycle)"
xref: Reactome:547513 "Citric acid cycle (TCA cycle)"
xref: Reactome:552177 "Citric acid cycle (TCA cycle)"
xref: Reactome:557691 "Citric acid cycle (TCA cycle)"
xref: Reactome:568313 "Citric acid cycle (TCA cycle)"
xref: Reactome:581515 "Citric acid cycle (TCA cycle)"
xref: Reactome:585940 "Citric acid cycle (TCA cycle)"
xref: Reactome:592472 "Citric acid cycle (TCA cycle)"
xref: Reactome:595333 "Citric acid cycle (TCA cycle)"
xref: Reactome:597334 "Citric acid cycle (TCA cycle)"
xref: Reactome:598139 "Citric acid cycle (TCA cycle)"
xref: Reactome:599596 "Citric acid cycle (TCA cycle)"
xref: Reactome:600653 "Citric acid cycle (TCA cycle)"
xref: Reactome:602459 "Citric acid cycle (TCA cycle)"
xref: Reactome:71403 "Citric acid cycle (TCA cycle)"
xref: Wikipedia:Tricarboxylic_acid_cycle
is_a: GO:0046356 ! acetyl-CoA catabolic process
relationship: part_of GO:0009060 ! aerobic respiration

[Term]
id: GO:0006100
name: tricarboxylic acid cycle intermediate metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving intermediates of the tricarboxylic acid cycle." [GOC:ai]
comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations.
synonym: "citric acid cycle intermediate metabolic process" EXACT []
synonym: "citric acid cycle intermediate metabolism" EXACT []
synonym: "Krebs cycle intermediate metabolic process" EXACT []
synonym: "Krebs cycle intermediate metabolism" EXACT []
synonym: "TCA intermediate metabolic process" EXACT []
synonym: "TCA intermediate metabolism" EXACT []
synonym: "tricarboxylic acid cycle intermediate metabolism" EXACT []
is_obsolete: true
consider: GO:0006099
consider: GO:0006101
consider: GO:0006103
consider: GO:0006104
consider: GO:0006105
consider: GO:0006106
consider: GO:0006107
consider: GO:0006108

[Term]
id: GO:0006101
name: citrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "citrate metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0006102
name: isocitrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "isocitrate metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0006103
name: 2-oxoglutarate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "2-ketoglutarate metabolic process" EXACT []
synonym: "2-ketoglutarate metabolism" EXACT []
synonym: "2-oxoglutarate metabolism" EXACT []
synonym: "alpha-ketoglutarate metabolic process" EXACT []
synonym: "alpha-ketoglutarate metabolism" EXACT []
synonym: "alpha-oxoglutarate metabolic process" EXACT []
synonym: "alpha-oxoglutarate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006104
name: succinyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A." [GOC:ai]
subset: gosubset_prok
synonym: "succinyl-CoA metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process

[Term]
id: GO:0006105
name: succinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "succinate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006106
name: fumarate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "fumarate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006107
name: oxaloacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "oxaloacetate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006108
name: malate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "malate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0006109
name: regulation of carbohydrate metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of carbohydrate metabolism" EXACT []
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0005975 ! carbohydrate metabolic process

[Term]
id: GO:0006110
name: regulation of glycolysis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycolysis." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
relationship: regulates GO:0006096 ! glycolysis

[Term]
id: GO:0006111
name: regulation of gluconeogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of glucose biosynthesis" BROAD []
synonym: "regulation of glucose biosynthetic process" BROAD []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
relationship: regulates GO:0006094 ! gluconeogenesis

[Term]
id: GO:0006112
name: energy reserve metabolic process
namespace: biological_process
def: "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "energy reserve metabolism" EXACT []
xref: Reactome:163685 "Integration of energy metabolism"
xref: Reactome:448491 "Integration of energy metabolism"
xref: Reactome:469621 "Integration of energy metabolism"
xref: Reactome:487340 "Integration of energy metabolism"
xref: Reactome:507291 "Integration of energy metabolism"
xref: Reactome:517305 "Integration of energy metabolism"
xref: Reactome:526190 "Integration of energy metabolism"
xref: Reactome:531080 "Integration of energy metabolism"
xref: Reactome:536453 "Integration of energy metabolism"
xref: Reactome:542157 "Integration of energy metabolism"
xref: Reactome:547515 "Integration of energy metabolism"
xref: Reactome:552152 "Integration of energy metabolism"
xref: Reactome:557694 "Integration of energy metabolism"
xref: Reactome:568315 "Integration of energy metabolism"
xref: Reactome:581517 "Integration of energy metabolism"
xref: Reactome:585777 "Integration of energy metabolism"
xref: Reactome:592453 "Integration of energy metabolism"
xref: Reactome:595323 "Integration of energy metabolism"
xref: Reactome:597293 "Integration of energy metabolism"
xref: Reactome:598102 "Integration of energy metabolism"
xref: Reactome:599599 "Integration of energy metabolism"
xref: Reactome:600582 "Integration of energy metabolism"
xref: Reactome:602450 "Integration of energy metabolism"
is_a: GO:0015980 ! energy derivation by oxidation of organic compounds

[Term]
id: GO:0006113
name: fermentation
namespace: biological_process
def: "The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, yielding energy in the form of adenosine triphosphate (ATP)." [http://cancerweb.ncl.ac.uk/]
subset: goslim_pir
subset: gosubset_prok
xref: MetaCyc:FERMENTATION-PWY
xref: Wikipedia:Fermentation_(biochemistry)
is_a: GO:0015980 ! energy derivation by oxidation of organic compounds

[Term]
id: GO:0006114
name: glycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycerol anabolism" EXACT []
synonym: "glycerol biosynthesis" EXACT []
synonym: "glycerol formation" EXACT []
synonym: "glycerol synthesis" EXACT []
is_a: GO:0006071 ! glycerol metabolic process
is_a: GO:0019401 ! alditol biosynthetic process
relationship: part_of GO:0006113 ! fermentation

[Term]
id: GO:0006115
name: ethanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ethanol anabolism" EXACT []
synonym: "ethanol biosynthesis" EXACT []
synonym: "ethanol formation" EXACT []
synonym: "ethanol synthesis" EXACT []
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0034309 ! monohydric alcohol biosynthetic process

[Term]
id: GO:0006116
name: NADH oxidation
namespace: biological_process
def: "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD." [GOC:ai]
subset: gosubset_prok
synonym: "NAD (reduced) dehydrogenation" EXACT []
synonym: "NAD (reduced) oxidation" EXACT []
synonym: "NADH dehydrogenation" EXACT []
synonym: "reduced NAD dehydrogenation" EXACT []
synonym: "reduced NAD oxidation" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide dehydrogenation" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide oxidation" EXACT []
is_a: GO:0006734 ! NADH metabolic process

[Term]
id: GO:0006117
name: acetaldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "acetaldehyde metabolism" EXACT []
synonym: "ethanal metabolic process" EXACT []
synonym: "ethanal metabolism" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process

[Term]
id: GO:0006118
name: electron transport
namespace: biological_process
def: "OBSOLETE. The transport of electrons from an electron donor to an electron acceptor." [http://cancerweb.ncl.ac.uk/]
comment: This term was made obsolete because it describes a molecular function.
synonym: "6-phosphofructokinase reduction" RELATED []
synonym: "dihydrobiopterin reduction" RELATED []
synonym: "dihydrolipoamide reduction" RELATED []
synonym: "dihydrolipoylprotein reduction" RELATED []
synonym: "dihydropteridine reduction" RELATED []
synonym: "electron transfer" EXACT []
synonym: "other pathways of electron transport" RELATED []
synonym: "oxidized glutathione reduction" RELATED []
synonym: "protein-disulfide reduction" RELATED []
is_obsolete: true
replaced_by: GO:0055114
consider: GO:0016491
consider: GO:0022904

[Term]
id: GO:0006119
name: oxidative phosphorylation
namespace: biological_process
def: "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0471331309 "Biochemical Pathways"]
subset: goslim_pir
subset: gosubset_prok
synonym: "respiratory-chain phosphorylation" EXACT []
xref: Wikipedia:Oxidative_phosphorylation
is_a: GO:0006091 ! generation of precursor metabolites and energy
is_a: GO:0016310 ! phosphorylation

[Term]
id: GO:0006120
name: mitochondrial electron transport, NADH to ubiquinone
namespace: biological_process
def: "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363]
synonym: "complex I (NADH to ubiquinone)" RELATED []
synonym: "oxidative phosphorylation, NADH to ubiquinone" EXACT []
xref: Reactome:163217 "NADH enters the respiratory chain at Complex I"
xref: Reactome:442764 "NADH enters the respiratory chain at Complex I"
xref: Reactome:464505 "NADH enters the respiratory chain at Complex I"
xref: Reactome:482848 "NADH enters the respiratory chain at Complex I"
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport

[Term]
id: GO:0006121
name: mitochondrial electron transport, succinate to ubiquinone
namespace: biological_process
def: "The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II." [ISBN:0716731363]
synonym: "complex II (succinate to ubiquinone)" RELATED []
synonym: "mitochondrial electron transport, succinate to coenzyme Q" EXACT []
synonym: "oxidative phosphorylation, succinate to ubiquinone" EXACT []
xref: Reactome:163213 "Transfer of electrons through the succinate dehydrogenase complex"
xref: Reactome:165642 "Transfer of electrons through the bovine succinate dehydrogenase complex"
xref: Reactome:447708 "Transfer of electrons through the succinate dehydrogenase complex"
xref: Reactome:468912 "Transfer of electrons through the succinate dehydrogenase complex"
xref: Reactome:486736 "Transfer of electrons through the succinate dehydrogenase complex"
xref: Reactome:506569 "Transfer of electrons through the succinate dehydrogenase complex"
xref: Reactome:516935 "Transfer of electrons through the succinate dehydrogenase complex"
xref: Reactome:525821 "Transfer of electrons through the succinate dehydrogenase complex"
xref: Reactome:530855 "Transfer of electrons through the succinate dehydrogenase complex"
xref: Reactome:536230 "Transfer of electrons through the succinate dehydrogenase complex"
xref: Reactome:541889 "Transfer of electrons through the succinate dehydrogenase complex"
xref: Reactome:547305 "Transfer of electrons through the succinate dehydrogenase complex"
xref: Reactome:551900 "Transfer of electrons through the succinate dehydrogenase complex"
xref: Reactome:567847 "Transfer of electrons through the succinate dehydrogenase complex"
xref: Reactome:592160 "Transfer of electrons through the succinate dehydrogenase complex"
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport

[Term]
id: GO:0006122
name: mitochondrial electron transport, ubiquinol to cytochrome c
namespace: biological_process
def: "The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363]
synonym: "complex III (ubiquinone to cytochrome c)" RELATED []
xref: Reactome:164651 "Electron transfer from ubiquinol to cytochrome c of complex III"
xref: Reactome:437520 "Electron transfer from ubiquinol to cytochrome c of complex III"
xref: Reactome:459631 "Electron transfer from ubiquinol to cytochrome c of complex III"
xref: Reactome:478778 "Electron transfer from ubiquinol to cytochrome c of complex III"
xref: Reactome:498544 "Electron transfer from ubiquinol to cytochrome c of complex III"
xref: Reactome:513290 "Electron transfer from ubiquinol to cytochrome c of complex III"
xref: Reactome:522389 "Electron transfer from ubiquinol to cytochrome c of complex III"
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport

[Term]
id: GO:0006123
name: mitochondrial electron transport, cytochrome c to oxygen
namespace: biological_process
def: "The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363]
synonym: "complex IV (reduction of O2)" RELATED []
xref: Reactome:163214 "Electron transfer from reduced cytochrome c to molecular oxygen"
xref: Reactome:437492 "Electron transfer from reduced cytochrome c to molecular oxygen"
xref: Reactome:459598 "Electron transfer from reduced cytochrome c to molecular oxygen"
xref: Reactome:478751 "Electron transfer from reduced cytochrome c to molecular oxygen"
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport

[Term]
id: GO:0006124
name: ferredoxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ferredoxin metabolism" EXACT []
is_a: GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0006125
name: thioredoxin pathway
namespace: biological_process
def: "OBSOLETE." [GOC:mtg_electron_transport]
comment: This term was made obsolete because it is not clear what it is intended to represent.
synonym: "thioredoxin reduction" NARROW []
xref: MetaCyc:THIOREDOX-PWY
is_obsolete: true
consider: GO:0045454

[Term]
id: GO:0006126
name: other pathways of electron transport
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
replaced_by: GO:0022900

[Term]
id: GO:0006127
name: glycerophosphate shuttle
namespace: biological_process
def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0006839 ! mitochondrial transport
relationship: part_of GO:0022904 ! respiratory electron transport chain

[Term]
id: GO:0006128
name: oxidized glutathione reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the term string represents a molecular function and not a biological pathway.
is_obsolete: true
consider: GO:0004362
consider: GO:0006749
consider: GO:0022900

[Term]
id: GO:0006129
name: protein-disulfide reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
synonym: "protein-disulphide reduction" EXACT []
is_obsolete: true
consider: GO:0019153
consider: GO:0022900

[Term]
id: GO:0006130
name: 6-phosphofructokinase reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the term string was ambiguous and the term may represent a molecular function.
is_obsolete: true
consider: GO:0003872
consider: GO:0022900

[Term]
id: GO:0006131
name: dihydrolipoamide reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
is_obsolete: true
consider: GO:0004148
consider: GO:0022900
consider: GO:0051068

[Term]
id: GO:0006132
name: dihydrolipoylprotein reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
is_obsolete: true
consider: GO:0004148
consider: GO:0022900

[Term]
id: GO:0006133
name: 5,10-methylenetetrahydrofolate oxidation
namespace: biological_process
def: "OBSOLETE." [GOC:mtg_electron_transport]
comment: This term was made obsolete because it is defined as a function term and is in the process ontology.
is_obsolete: true
consider: GO:0004487
consider: GO:0004488
consider: GO:0004489
consider: GO:0033738

[Term]
id: GO:0006134
name: dihydrobiopterin reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
is_obsolete: true
consider: GO:0022900
consider: GO:0047040
consider: GO:0051066

[Term]
id: GO:0006135
name: dihydropteridine reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
is_obsolete: true
consider: GO:0004155
consider: GO:0022900
consider: GO:0051067

[Term]
id: GO:0006139
name: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
namespace: biological_process
alt_id: GO:0055134
def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai]
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044238 ! primary metabolic process

[Term]
id: GO:0006140
name: regulation of nucleotide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of nucleotide metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
relationship: regulates GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0006141
name: regulation of purine base metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of purine base metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
relationship: regulates GO:0006144 ! purine base metabolic process

[Term]
id: GO:0006142
name: regulation of pyrimidine base metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidines." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of pyrimidine base metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
relationship: regulates GO:0006206 ! pyrimidine base metabolic process

[Term]
id: GO:0006143
name: purine metabolic process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more appropriate terms were created.
is_obsolete: true
consider: GO:0006144
consider: GO:0006163
consider: GO:0042278

[Term]
id: GO:0006144
name: purine base metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators]
subset: gosubset_prok
synonym: "purine base metabolism" EXACT []
synonym: "purine metabolic process" NARROW []
synonym: "purine metabolism" NARROW []
xref: Reactome:448519 "Purine metabolism"
xref: Reactome:469649 "Purine metabolism"
xref: Reactome:487361 "Purine metabolism"
xref: Reactome:507312 "Purine metabolism"
xref: Reactome:517327 "Purine metabolism"
xref: Reactome:526209 "Purine metabolism"
xref: Reactome:531095 "Purine metabolism"
xref: Reactome:536468 "Purine metabolism"
xref: Reactome:542172 "Purine metabolism"
xref: Reactome:547532 "Purine metabolism"
xref: Reactome:552123 "Purine metabolism"
xref: Reactome:557714 "Purine metabolism"
xref: Reactome:568330 "Purine metabolism"
xref: Reactome:581532 "Purine metabolism"
xref: Reactome:585750 "Purine metabolism"
xref: Reactome:592419 "Purine metabolism"
xref: Reactome:595303 "Purine metabolism"
xref: Reactome:597276 "Purine metabolism"
xref: Reactome:598082 "Purine metabolism"
xref: Reactome:599618 "Purine metabolism"
xref: Reactome:600558 "Purine metabolism"
xref: Reactome:602422 "Purine metabolism"
xref: Reactome:73847 "Purine metabolism"
is_a: GO:0009112 ! nucleobase metabolic process

[Term]
id: GO:0006145
name: purine base catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators]
subset: gosubset_prok
synonym: "purine base breakdown" EXACT []
synonym: "purine base catabolism" EXACT []
synonym: "purine base degradation" EXACT []
is_a: GO:0006144 ! purine base metabolic process
is_a: GO:0046113 ! nucleobase catabolic process

[Term]
id: GO:0006146
name: adenine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "adenine breakdown" EXACT []
synonym: "adenine catabolism" EXACT []
synonym: "adenine degradation" EXACT []
is_a: GO:0006145 ! purine base catabolic process
is_a: GO:0046083 ! adenine metabolic process

[Term]
id: GO:0006147
name: guanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators]
subset: gosubset_prok
synonym: "guanine breakdown" EXACT []
synonym: "guanine catabolism" EXACT []
synonym: "guanine degradation" EXACT []
is_a: GO:0006145 ! purine base catabolic process
is_a: GO:0046098 ! guanine metabolic process

[Term]
id: GO:0006148
name: inosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators]
subset: gosubset_prok
synonym: "inosine breakdown" EXACT []
synonym: "inosine catabolism" EXACT []
synonym: "inosine degradation" EXACT []
is_a: GO:0046102 ! inosine metabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process

[Term]
id: GO:0006149
name: deoxyinosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyinosine breakdown" EXACT []
synonym: "deoxyinosine catabolism" EXACT []
synonym: "deoxyinosine degradation" EXACT []
is_a: GO:0046094 ! deoxyinosine metabolic process
is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process

[Term]
id: GO:0006150
name: hypoxanthine oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hypoxanthine to xanthine and thence to uric acid." [GOC:mah, PMID:3196295]
subset: gosubset_prok
is_a: GO:0009114 ! hypoxanthine catabolic process

[Term]
id: GO:0006151
name: xanthine oxidation
namespace: biological_process
def: "The oxidation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:jl]
subset: gosubset_prok
is_a: GO:0009115 ! xanthine catabolic process

[Term]
id: GO:0006152
name: purine nucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators]
subset: gosubset_prok
synonym: "purine nucleoside breakdown" EXACT []
synonym: "purine nucleoside catabolism" EXACT []
synonym: "purine nucleoside degradation" EXACT []
is_a: GO:0009164 ! nucleoside catabolic process
is_a: GO:0042278 ! purine nucleoside metabolic process

[Term]
id: GO:0006153
name: purine nucleosidase reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
is_obsolete: true
replaced_by: GO:0008477

[Term]
id: GO:0006154
name: adenosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators]
subset: gosubset_prok
synonym: "adenosine breakdown" EXACT []
synonym: "adenosine catabolism" EXACT []
synonym: "adenosine degradation" EXACT []
is_a: GO:0046085 ! adenosine metabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process

[Term]
id: GO:0006155
name: adenosine deaminase reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
is_obsolete: true
replaced_by: GO:0004000

[Term]
id: GO:0006156
name: adenosine phosphorolysis
namespace: biological_process
subset: gosubset_prok
is_a: GO:0006154 ! adenosine catabolic process

[Term]
id: GO:0006157
name: deoxyadenosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyadenosine breakdown" EXACT []
synonym: "deoxyadenosine catabolism" EXACT []
synonym: "deoxyadenosine degradation" EXACT []
is_a: GO:0046090 ! deoxyadenosine metabolic process
is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process

[Term]
id: GO:0006158
name: deoxyadenosine deaminase reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
is_obsolete: true
replaced_by: GO:0046936

[Term]
id: GO:0006159
name: deoxyadenosine phosphorolysis
namespace: biological_process
subset: gosubset_prok
is_a: GO:0006157 ! deoxyadenosine catabolic process

[Term]
id: GO:0006160
name: guanosine phosphorolysis
namespace: biological_process
subset: gosubset_prok
is_a: GO:0008617 ! guanosine metabolic process

[Term]
id: GO:0006161
name: deoxyguanosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "deoxyguanosine breakdown" EXACT []
synonym: "deoxyguanosine catabolism" EXACT []
synonym: "deoxyguanosine degradation" EXACT []
is_a: GO:0042453 ! deoxyguanosine metabolic process
is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process

[Term]
id: GO:0006162
name: purine/pyrimidine nucleoside diphosphate reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
is_obsolete: true
consider: GO:0004748

[Term]
id: GO:0006163
name: purine nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine metabolic process" NARROW []
synonym: "purine metabolism" NARROW []
synonym: "purine nucleotide metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0006164
name: purine nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine nucleotide anabolism" EXACT []
synonym: "purine nucleotide biosynthesis" EXACT []
synonym: "purine nucleotide formation" EXACT []
synonym: "purine nucleotide synthesis" EXACT []
xref: MetaCyc:DENOVOPURINE2-PWY
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0006165
name: nucleoside diphosphate phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0009132 ! nucleoside diphosphate metabolic process
is_a: GO:0046939 ! nucleotide phosphorylation

[Term]
id: GO:0006166
name: purine ribonucleoside salvage
namespace: biological_process
def: "Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
xref: MetaCyc:P121-PWY
is_a: GO:0043101 ! purine salvage
is_a: GO:0043174 ! nucleoside salvage
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0006167
name: AMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "AMP anabolism" EXACT []
synonym: "AMP biosynthesis" EXACT []
synonym: "AMP formation" EXACT []
synonym: "AMP synthesis" EXACT []
is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process
is_a: GO:0046033 ! AMP metabolic process

[Term]
id: GO:0006168
name: adenine salvage
namespace: biological_process
def: "Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "adenine salvage pathway" EXACT []
synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD []
is_a: GO:0043096 ! purine base salvage
is_a: GO:0046084 ! adenine biosynthetic process

[Term]
id: GO:0006169
name: adenosine salvage
namespace: biological_process
def: "Any process that generates adenosine, adenine riboside, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD []
is_a: GO:0006166 ! purine ribonucleoside salvage
is_a: GO:0046086 ! adenosine biosynthetic process

[Term]
id: GO:0006170
name: dAMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dAMP anabolism" EXACT []
synonym: "dAMP biosynthesis" EXACT []
synonym: "dAMP formation" EXACT []
synonym: "dAMP synthesis" EXACT []
is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0046053 ! dAMP metabolic process

[Term]
id: GO:0006171
name: cAMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "3',5' cAMP biosynthesis" EXACT []
synonym: "3',5' cAMP biosynthetic process" EXACT []
synonym: "3',5'-cAMP biosynthesis" EXACT []
synonym: "3',5'-cAMP biosynthetic process" EXACT []
synonym: "adenosine 3',5'-cyclophosphate biosynthesis" EXACT []
synonym: "adenosine 3',5'-cyclophosphate biosynthetic process" EXACT []
synonym: "cAMP anabolism" EXACT []
synonym: "cAMP biosynthesis" EXACT []
synonym: "cAMP formation" EXACT []
synonym: "cAMP synthesis" EXACT []
synonym: "cyclic AMP biosynthesis" EXACT []
synonym: "cyclic AMP biosynthetic process" EXACT []
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0009190 ! cyclic nucleotide biosynthetic process
is_a: GO:0046058 ! cAMP metabolic process

[Term]
id: GO:0006172
name: ADP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "ADP anabolism" EXACT []
synonym: "ADP biosynthesis" EXACT []
synonym: "ADP formation" EXACT []
synonym: "ADP synthesis" EXACT []
is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process
is_a: GO:0046031 ! ADP metabolic process

[Term]
id: GO:0006173
name: dADP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dADP anabolism" EXACT []
synonym: "dADP biosynthesis" EXACT []
synonym: "dADP formation" EXACT []
synonym: "dADP synthesis" EXACT []
is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0046056 ! dADP metabolic process

[Term]
id: GO:0006174
name: dADP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into dADP, deoxyadenosine diphosphate, to produce dATP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0006165 ! nucleoside diphosphate phosphorylation
is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0046056 ! dADP metabolic process

[Term]
id: GO:0006175
name: dATP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dATP anabolism" EXACT []
synonym: "dATP biosynthesis" EXACT []
synonym: "dATP formation" EXACT []
synonym: "dATP synthesis" EXACT []
xref: Reactome:448530 "dATP formation"
xref: Reactome:469659 "dATP formation"
xref: Reactome:487372 "dATP formation"
xref: Reactome:507323 "dATP formation"
xref: Reactome:517337 "dATP formation"
xref: Reactome:526217 "dATP formation"
xref: Reactome:531100 "dATP formation"
xref: Reactome:536476 "dATP formation"
xref: Reactome:542180 "dATP formation"
xref: Reactome:547540 "dATP formation"
xref: Reactome:552131 "dATP formation"
xref: Reactome:557722 "dATP formation"
xref: Reactome:568340 "dATP formation"
xref: Reactome:581542 "dATP formation"
xref: Reactome:585759 "dATP formation"
xref: Reactome:592430 "dATP formation"
xref: Reactome:595308 "dATP formation"
xref: Reactome:597274 "dATP formation"
xref: Reactome:598080 "dATP formation"
xref: Reactome:599624 "dATP formation"
xref: Reactome:600561 "dATP formation"
xref: Reactome:602425 "dATP formation"
xref: Reactome:74230 "dATP formation"
is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0046060 ! dATP metabolic process

[Term]
id: GO:0006176
name: dATP biosynthetic process from ADP
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate) from other compounds, including ADP, adenosine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dATP anabolism from ADP" EXACT []
synonym: "dATP formation from ADP" EXACT []
synonym: "dATP synthesis from ADP" EXACT []
is_a: GO:0006175 ! dATP biosynthetic process
is_a: GO:0046031 ! ADP metabolic process

[Term]
id: GO:0006177
name: GMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "GMP anabolism" EXACT []
synonym: "GMP biosynthesis" EXACT []
synonym: "GMP formation" EXACT []
synonym: "GMP synthesis" EXACT []
is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process
is_a: GO:0046037 ! GMP metabolic process

[Term]
id: GO:0006178
name: guanine salvage
namespace: biological_process
def: "Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "guanine, xanthine and their nucleoside salvage" BROAD []
is_a: GO:0043096 ! purine base salvage
is_a: GO:0046099 ! guanine biosynthetic process

[Term]
id: GO:0006179
name: guanosine salvage
namespace: biological_process
def: "Any process that generates guanosine, guanine riboside, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "guanine, xanthine and their nucleoside salvage" BROAD []
is_a: GO:0006166 ! purine ribonucleoside salvage
is_a: GO:0046114 ! guanosine biosynthetic process

[Term]
id: GO:0006180
name: deoxyguanosine salvage
namespace: biological_process
def: "Any process that generates deoxyguanosine from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043098 ! purine deoxyribonucleoside salvage

[Term]
id: GO:0006181
name: dGMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dGMP anabolism" EXACT []
synonym: "dGMP biosynthesis" EXACT []
synonym: "dGMP formation" EXACT []
synonym: "dGMP synthesis" EXACT []
is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0046054 ! dGMP metabolic process

[Term]
id: GO:0006182
name: cGMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cGMP anabolism" EXACT []
synonym: "cGMP biosynthesis" EXACT []
synonym: "cGMP formation" EXACT []
synonym: "cGMP synthesis" EXACT []
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0009190 ! cyclic nucleotide biosynthetic process
is_a: GO:0046068 ! cGMP metabolic process

[Term]
id: GO:0006183
name: GTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "GTP anabolism" EXACT []
synonym: "GTP biosynthesis" EXACT []
synonym: "GTP formation" EXACT []
synonym: "GTP synthesis" EXACT []
is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process
is_a: GO:0046039 ! GTP metabolic process

[Term]
id: GO:0006184
name: GTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "GTP breakdown" EXACT []
synonym: "GTP catabolism" EXACT []
synonym: "GTP degradation" EXACT []
synonym: "GTP hydrolysis" EXACT []
is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process
is_a: GO:0046039 ! GTP metabolic process

[Term]
id: GO:0006185
name: dGDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dGDP anabolism" EXACT []
synonym: "dGDP biosynthesis" EXACT []
synonym: "dGDP formation" EXACT []
synonym: "dGDP synthesis" EXACT []
is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0046066 ! dGDP metabolic process

[Term]
id: GO:0006186
name: dGDP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into dGDP, deoxyguanosine diphosphate, to produce dGTP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0006165 ! nucleoside diphosphate phosphorylation
is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0046066 ! dGDP metabolic process

[Term]
id: GO:0006187
name: dGTP biosynthetic process from dGDP
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dGTP, deoxyguanosine triphosphate (2'-deoxyguanosine 5'-triphosphate) from other compounds, including gGDP, deoxyguanosine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dGTP anabolism from dGDP" EXACT []
synonym: "dGTP formation from dGDP" EXACT []
synonym: "dGTP synthesis from dGDP" EXACT []
is_a: GO:0046066 ! dGDP metabolic process
is_a: GO:0046071 ! dGTP biosynthetic process

[Term]
id: GO:0006188
name: IMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "IMP anabolism" EXACT []
synonym: "IMP biosynthesis" EXACT []
synonym: "IMP formation" EXACT []
synonym: "IMP synthesis" EXACT []
is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process
is_a: GO:0046040 ! IMP metabolic process

[Term]
id: GO:0006189
name: 'de novo' IMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094]
subset: gosubset_prok
synonym: "'de novo' IMP anabolism" EXACT []
synonym: "'de novo' IMP biosynthesis" EXACT []
synonym: "'de novo' IMP formation" EXACT []
synonym: "'de novo' IMP synthesis" EXACT []
synonym: "'de novo' purine biosynthesis" BROAD []
synonym: "'de novo' purine biosynthetic process" BROAD []
xref: Reactome:448594 "De novo synthesis of IMP"
xref: Reactome:469723 "De novo synthesis of IMP"
xref: Reactome:487434 "De novo synthesis of IMP"
xref: Reactome:507391 "De novo synthesis of IMP"
xref: Reactome:517393 "De novo synthesis of IMP"
xref: Reactome:526268 "De novo synthesis of IMP"
xref: Reactome:531140 "De novo synthesis of IMP"
xref: Reactome:536512 "De novo synthesis of IMP"
xref: Reactome:542230 "De novo synthesis of IMP"
xref: Reactome:547580 "De novo synthesis of IMP"
xref: Reactome:552189 "De novo synthesis of IMP"
xref: Reactome:557774 "De novo synthesis of IMP"
xref: Reactome:568386 "De novo synthesis of IMP"
xref: Reactome:581588 "De novo synthesis of IMP"
xref: Reactome:592484 "De novo synthesis of IMP"
xref: Reactome:597305 "De novo synthesis of IMP"
xref: Reactome:598106 "De novo synthesis of IMP"
xref: Reactome:599655 "De novo synthesis of IMP"
xref: Reactome:600586 "De novo synthesis of IMP"
xref: Reactome:602469 "De novo synthesis of IMP"
xref: Reactome:73817 "De novo synthesis of IMP"
is_a: GO:0006188 ! IMP biosynthetic process

[Term]
id: GO:0006190
name: inosine salvage
namespace: biological_process
def: "Any process that generates inosine, hypoxanthine riboside, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "adenine, hypoxanthine and their nucleoside salvage" RELATED []
synonym: "guanine, xanthine and their nucleoside salvage" RELATED []
is_a: GO:0006166 ! purine ribonucleoside salvage
is_a: GO:0046103 ! inosine biosynthetic process

[Term]
id: GO:0006191
name: deoxyinosine salvage
namespace: biological_process
def: "Any process that generates deoxyinosine from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043098 ! purine deoxyribonucleoside salvage
is_a: GO:0046095 ! deoxyinosine biosynthetic process

[Term]
id: GO:0006192
name: IDP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into IDP, inosine (5'-)diphosphate, to produce ITP." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006165 ! nucleoside diphosphate phosphorylation
is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process
is_a: GO:0046707 ! IDP metabolic process

[Term]
id: GO:0006193
name: ITP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ITP, inosine (5'-)triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ITP breakdown" EXACT []
synonym: "ITP catabolism" EXACT []
synonym: "ITP degradation" EXACT []
synonym: "ITP hydrolysis" EXACT []
is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process
is_a: GO:0046041 ! ITP metabolic process

[Term]
id: GO:0006194
name: dIDP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into dIDP, deoxyinosine diphosphate, to produce dITP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0006165 ! nucleoside diphosphate phosphorylation
is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process

[Term]
id: GO:0006195
name: purine nucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine nucleotide breakdown" EXACT []
synonym: "purine nucleotide catabolism" EXACT []
synonym: "purine nucleotide degradation" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0006196
name: AMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "AMP breakdown" EXACT []
synonym: "AMP catabolism" EXACT []
synonym: "AMP degradation" EXACT []
is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process
is_a: GO:0046033 ! AMP metabolic process

[Term]
id: GO:0006197
name: adenylate deaminase reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
is_obsolete: true
replaced_by: GO:0003876

[Term]
id: GO:0006198
name: cAMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "3',5' cAMP catabolic process" EXACT []
synonym: "3',5' cAMP catabolism" EXACT []
synonym: "3',5'-cAMP catabolic process" EXACT []
synonym: "3',5'-cAMP catabolism" EXACT []
synonym: "adenosine 3',5'-cyclophosphate catabolic process" EXACT []
synonym: "adenosine 3',5'-cyclophosphate catabolism" EXACT []
synonym: "cAMP breakdown" EXACT []
synonym: "cAMP catabolism" EXACT []
synonym: "cAMP degradation" EXACT []
synonym: "cyclic AMP catabolic process" EXACT []
synonym: "cyclic AMP catabolism" EXACT []
is_a: GO:0006195 ! purine nucleotide catabolic process
is_a: GO:0009214 ! cyclic nucleotide catabolic process
is_a: GO:0046058 ! cAMP metabolic process

[Term]
id: GO:0006199
name: ADP reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
is_obsolete: true
consider: GO:0051061

[Term]
id: GO:0006200
name: ATP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai]
subset: gosubset_prok
synonym: "ATP breakdown" EXACT []
synonym: "ATP catabolism" EXACT []
synonym: "ATP degradation" EXACT []
synonym: "ATP hydrolysis" EXACT []
xref: Wikipedia:ATP_hydrolysis
is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process
is_a: GO:0046034 ! ATP metabolic process

[Term]
id: GO:0006201
name: GMP catabolic process to IMP
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including inosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "GMP breakdown to IMP" EXACT []
synonym: "GMP degradation to IMP" EXACT []
is_a: GO:0046038 ! GMP catabolic process
is_a: GO:0046040 ! IMP metabolic process

[Term]
id: GO:0006202
name: GMP catabolic process to guanine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including guanine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "GMP breakdown to guanine" EXACT []
synonym: "GMP degradation to guanine" EXACT []
is_a: GO:0046038 ! GMP catabolic process
is_a: GO:0046098 ! guanine metabolic process

[Term]
id: GO:0006203
name: dGTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dGTP breakdown" EXACT []
synonym: "dGTP catabolism" EXACT []
synonym: "dGTP degradation" EXACT []
is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0046070 ! dGTP metabolic process

[Term]
id: GO:0006204
name: IMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of IMP, inosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "IMP breakdown" EXACT []
synonym: "IMP catabolism" EXACT []
synonym: "IMP degradation" EXACT []
is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process
is_a: GO:0046040 ! IMP metabolic process

[Term]
id: GO:0006205
name: pyrimidine metabolic process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more appropriate terms were created.
is_obsolete: true
consider: GO:0006206
consider: GO:0006213
consider: GO:0006220

[Term]
id: GO:0006206
name: pyrimidine base metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine bases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators]
subset: gosubset_prok
synonym: "pyrimidine base metabolism" EXACT []
synonym: "pyrimidine metabolic process" BROAD []
synonym: "pyrimidine metabolism" BROAD []
xref: Reactome:448477 "Pyrimidine metabolism"
xref: Reactome:469607 "Pyrimidine metabolism"
xref: Reactome:487326 "Pyrimidine metabolism"
xref: Reactome:507277 "Pyrimidine metabolism"
xref: Reactome:517297 "Pyrimidine metabolism"
xref: Reactome:526176 "Pyrimidine metabolism"
xref: Reactome:531066 "Pyrimidine metabolism"
xref: Reactome:536445 "Pyrimidine metabolism"
xref: Reactome:542143 "Pyrimidine metabolism"
xref: Reactome:547507 "Pyrimidine metabolism"
xref: Reactome:552099 "Pyrimidine metabolism"
xref: Reactome:557683 "Pyrimidine metabolism"
xref: Reactome:568301 "Pyrimidine metabolism"
xref: Reactome:581503 "Pyrimidine metabolism"
xref: Reactome:585768 "Pyrimidine metabolism"
xref: Reactome:592439 "Pyrimidine metabolism"
xref: Reactome:595287 "Pyrimidine metabolism"
xref: Reactome:597285 "Pyrimidine metabolism"
xref: Reactome:598091 "Pyrimidine metabolism"
xref: Reactome:599588 "Pyrimidine metabolism"
xref: Reactome:600546 "Pyrimidine metabolism"
xref: Reactome:602399 "Pyrimidine metabolism"
xref: Reactome:73848 "Pyrimidine metabolism"
is_a: GO:0009112 ! nucleobase metabolic process

[Term]
id: GO:0006207
name: 'de novo' pyrimidine base biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094]
subset: gosubset_prok
synonym: "'de novo' pyrimidine base anabolism" EXACT []
synonym: "'de novo' pyrimidine base biosynthesis" EXACT []
synonym: "'de novo' pyrimidine base formation" EXACT []
synonym: "'de novo' pyrimidine base synthesis" EXACT []
is_a: GO:0019856 ! pyrimidine base biosynthetic process

[Term]
id: GO:0006208
name: pyrimidine base catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine bases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators]
subset: gosubset_prok
synonym: "pyrimidine base breakdown" EXACT []
synonym: "pyrimidine base catabolism" EXACT []
synonym: "pyrimidine base degradation" EXACT []
is_a: GO:0006206 ! pyrimidine base metabolic process
is_a: GO:0046113 ! nucleobase catabolic process

[Term]
id: GO:0006209
name: cytosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:go_curators]
subset: gosubset_prok
synonym: "cytosine breakdown" EXACT []
synonym: "cytosine catabolism" EXACT []
synonym: "cytosine degradation" EXACT []
is_a: GO:0006208 ! pyrimidine base catabolic process
is_a: GO:0019858 ! cytosine metabolic process

[Term]
id: GO:0006210
name: thymine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators]
subset: gosubset_prok
synonym: "thymine breakdown" EXACT []
synonym: "thymine catabolism" EXACT []
synonym: "thymine degradation" EXACT []
is_a: GO:0006208 ! pyrimidine base catabolic process
is_a: GO:0019859 ! thymine metabolic process

[Term]
id: GO:0006211
name: 5-methylcytosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 5-methylcytosine, a methylated base of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "5-methylcytosine breakdown" EXACT []
synonym: "5-methylcytosine catabolism" EXACT []
synonym: "5-methylcytosine degradation" EXACT []
is_a: GO:0006208 ! pyrimidine base catabolic process
is_a: GO:0019857 ! 5-methylcytosine metabolic process

[Term]
id: GO:0006212
name: uracil catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "uracil breakdown" EXACT []
synonym: "uracil catabolism" EXACT []
synonym: "uracil degradation" EXACT []
is_a: GO:0006208 ! pyrimidine base catabolic process
is_a: GO:0019860 ! uracil metabolic process

[Term]
id: GO:0006213
name: pyrimidine nucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713]
subset: gosubset_prok
synonym: "pyrimidine metabolic process" BROAD []
synonym: "pyrimidine metabolism" BROAD []
synonym: "pyrimidine nucleoside metabolism" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0006214
name: thymidine catabolic process
namespace: biological_process
alt_id: GO:0006215
def: "The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyribosylthymine catabolic process" EXACT []
synonym: "deoxyribosylthymine catabolism" EXACT []
synonym: "thymidine breakdown" EXACT []
synonym: "thymidine catabolism" EXACT []
synonym: "thymidine degradation" EXACT []
is_a: GO:0046104 ! thymidine metabolic process
is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process

[Term]
id: GO:0006216
name: cytidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:ai]
subset: gosubset_prok
synonym: "cytidine breakdown" EXACT []
synonym: "cytidine catabolism" EXACT []
synonym: "cytidine degradation" EXACT []
is_a: GO:0046087 ! cytidine metabolic process
is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process

[Term]
id: GO:0006217
name: deoxycytidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxycytidine breakdown" EXACT []
synonym: "deoxycytidine catabolism" EXACT []
synonym: "deoxycytidine degradation" EXACT []
is_a: GO:0046092 ! deoxycytidine metabolic process
is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process

[Term]
id: GO:0006218
name: uridine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "uridine breakdown" EXACT []
synonym: "uridine catabolism" EXACT []
synonym: "uridine degradation" EXACT []
is_a: GO:0046108 ! uridine metabolic process
is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process

[Term]
id: GO:0006219
name: deoxyuridine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyuridine breakdown" EXACT []
synonym: "deoxyuridine catabolism" EXACT []
synonym: "deoxyuridine degradation" EXACT []
is_a: GO:0046096 ! deoxyuridine metabolic process
is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process

[Term]
id: GO:0006220
name: pyrimidine nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine metabolic process" BROAD []
synonym: "pyrimidine metabolism" BROAD []
synonym: "pyrimidine nucleotide metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0006221
name: pyrimidine nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine nucleotide anabolism" EXACT []
synonym: "pyrimidine nucleotide biosynthesis" EXACT []
synonym: "pyrimidine nucleotide formation" EXACT []
synonym: "pyrimidine nucleotide synthesis" EXACT []
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0006222
name: UMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "UMP anabolism" EXACT []
synonym: "UMP biosynthesis" EXACT []
synonym: "UMP formation" EXACT []
synonym: "UMP synthesis" EXACT []
xref: Reactome:448476 "De novo synthesis of UMP"
xref: Reactome:469606 "De novo synthesis of UMP"
xref: Reactome:487325 "De novo synthesis of UMP"
xref: Reactome:507276 "De novo synthesis of UMP"
xref: Reactome:517296 "De novo synthesis of UMP"
xref: Reactome:526175 "De novo synthesis of UMP"
xref: Reactome:531065 "De novo synthesis of UMP"
xref: Reactome:536444 "De novo synthesis of UMP"
xref: Reactome:542142 "De novo synthesis of UMP"
xref: Reactome:547506 "De novo synthesis of UMP"
xref: Reactome:552098 "De novo synthesis of UMP"
xref: Reactome:557682 "De novo synthesis of UMP"
xref: Reactome:568300 "De novo synthesis of UMP"
xref: Reactome:581502 "De novo synthesis of UMP"
xref: Reactome:592686 "De novo synthesis of UMP"
xref: Reactome:595286 "De novo synthesis of UMP"
xref: Reactome:597374 "De novo synthesis of UMP"
xref: Reactome:598163 "De novo synthesis of UMP"
xref: Reactome:599587 "De novo synthesis of UMP"
xref: Reactome:600545 "De novo synthesis of UMP"
xref: Reactome:602398 "De novo synthesis of UMP"
xref: Reactome:73581 "De novo synthesis of UMP"
is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process
is_a: GO:0046049 ! UMP metabolic process

[Term]
id: GO:0006223
name: uracil salvage
namespace: biological_process
def: "Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0019860 ! uracil metabolic process
is_a: GO:0043100 ! pyrimidine base salvage

[Term]
id: GO:0006224
name: uridine kinase reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
is_obsolete: true
replaced_by: GO:0004849

[Term]
id: GO:0006225
name: UDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "UDP anabolism" EXACT []
synonym: "UDP biosynthesis" EXACT []
synonym: "UDP formation" EXACT []
synonym: "UDP synthesis" EXACT []
is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process
is_a: GO:0046048 ! UDP metabolic process

[Term]
id: GO:0006226
name: dUMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dUMP anabolism" EXACT []
synonym: "dUMP biosynthesis" EXACT []
synonym: "dUMP formation" EXACT []
synonym: "dUMP synthesis" EXACT []
is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0046078 ! dUMP metabolic process

[Term]
id: GO:0006227
name: dUDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dUDP anabolism" EXACT []
synonym: "dUDP biosynthesis" EXACT []
synonym: "dUDP formation" EXACT []
synonym: "dUDP synthesis" EXACT []
is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0046077 ! dUDP metabolic process

[Term]
id: GO:0006228
name: UTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "UTP anabolism" EXACT []
synonym: "UTP biosynthesis" EXACT []
synonym: "UTP formation" EXACT []
synonym: "UTP synthesis" EXACT []
is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process
is_a: GO:0046051 ! UTP metabolic process

[Term]
id: GO:0006229
name: dUTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dUTP, deoxyuridine (5'-)triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dUTP anabolism" EXACT []
synonym: "dUTP biosynthesis" EXACT []
synonym: "dUTP formation" EXACT []
synonym: "dUTP synthesis" EXACT []
is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0046080 ! dUTP metabolic process

[Term]
id: GO:0006230
name: TMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of TMP, ribosylthymine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "TMP anabolism" EXACT []
synonym: "TMP biosynthesis" EXACT []
synonym: "TMP formation" EXACT []
synonym: "TMP synthesis" EXACT []
is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process
is_a: GO:0046044 ! TMP metabolic process

[Term]
id: GO:0006231
name: dTMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dTMP anabolism" EXACT []
synonym: "dTMP biosynthesis" EXACT []
synonym: "dTMP formation" EXACT []
synonym: "dTMP synthesis" EXACT []
is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0046073 ! dTMP metabolic process

[Term]
id: GO:0006232
name: TDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of TDP, ribosylthymine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "TDP anabolism" EXACT []
synonym: "TDP biosynthesis" EXACT []
synonym: "TDP formation" EXACT []
synonym: "TDP synthesis" EXACT []
is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process
is_a: GO:0046043 ! TDP metabolic process

[Term]
id: GO:0006233
name: dTDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dTDP anabolism" EXACT []
synonym: "dTDP biosynthesis" EXACT []
synonym: "dTDP formation" EXACT []
synonym: "dTDP synthesis" EXACT []
is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0046072 ! dTDP metabolic process

[Term]
id: GO:0006234
name: TTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of TTP, ribosylthymine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "TTP anabolism" EXACT []
synonym: "TTP biosynthesis" EXACT []
synonym: "TTP formation" EXACT []
synonym: "TTP synthesis" EXACT []
is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process
is_a: GO:0046046 ! TTP metabolic process

[Term]
id: GO:0006235
name: dTTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dTTP anabolism" EXACT []
synonym: "dTTP biosynthesis" EXACT []
synonym: "dTTP formation" EXACT []
synonym: "dTTP synthesis" EXACT []
is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0046075 ! dTTP metabolic process

[Term]
id: GO:0006236
name: cytidine salvage
namespace: biological_process
def: "Any process that generates cytidine, cytosine riboside, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043097 ! pyrimidine nucleoside salvage
is_a: GO:0046088 ! cytidine biosynthetic process

[Term]
id: GO:0006237
name: deoxycytidine salvage
namespace: biological_process
def: "Any process that generates deoxycytidine, 2-deoxyribosylcytosine, from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043099 ! pyrimidine deoxyribonucleoside salvage
is_a: GO:0046093 ! deoxycytidine biosynthetic process

[Term]
id: GO:0006238
name: CMP salvage
namespace: biological_process
def: "Any process that generates CMP, cytidine monophosphate, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "cytidine monophosphate salvage" EXACT []
is_a: GO:0009224 ! CMP biosynthetic process
is_a: GO:0010138 ! pyrimidine ribonucleotide salvage

[Term]
id: GO:0006239
name: dCMP salvage
namespace: biological_process
def: "Any process that generates dCMP, deoxycytidine monophosphate from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "deoxycytidine monophosphate salvage" EXACT []
is_a: GO:0010139 ! pyrimidine deoxyribonucleotide salvage
is_a: GO:0046064 ! dCMP biosynthetic process

[Term]
id: GO:0006240
name: dCDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dCDP anabolism" EXACT []
synonym: "dCDP biosynthesis" EXACT []
synonym: "dCDP formation" EXACT []
synonym: "dCDP synthesis" EXACT []
is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0046062 ! dCDP metabolic process

[Term]
id: GO:0006241
name: CTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "CTP anabolism" EXACT []
synonym: "CTP biosynthesis" EXACT []
synonym: "CTP formation" EXACT []
synonym: "CTP synthesis" EXACT []
is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process
is_a: GO:0046036 ! CTP metabolic process

[Term]
id: GO:0006242
name: dCTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dCTP, deoxycytidine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dCTP anabolism" EXACT []
synonym: "dCTP biosynthesis" EXACT []
synonym: "dCTP formation" EXACT []
synonym: "dCTP synthesis" EXACT []
is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0046065 ! dCTP metabolic process

[Term]
id: GO:0006243
name: CTP deamination
namespace: biological_process
subset: gosubset_prok
is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process
is_a: GO:0046036 ! CTP metabolic process

[Term]
id: GO:0006244
name: pyrimidine nucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine nucleotide breakdown" EXACT []
synonym: "pyrimidine nucleotide catabolism" EXACT []
synonym: "pyrimidine nucleotide degradation" EXACT []
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0006245
name: TDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of TDP, ribosylthymine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "TDP breakdown" EXACT []
synonym: "TDP catabolism" EXACT []
synonym: "TDP degradation" EXACT []
is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process
is_a: GO:0046043 ! TDP metabolic process

[Term]
id: GO:0006246
name: dTDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dTDP, deoxyribosylthymine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dTDP breakdown" EXACT []
synonym: "dTDP catabolism" EXACT []
synonym: "dTDP degradation" EXACT []
is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process
is_a: GO:0046072 ! dTDP metabolic process

[Term]
id: GO:0006247
name: TTP reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
is_obsolete: true
consider: GO:0051064

[Term]
id: GO:0006248
name: CMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "CMP breakdown" EXACT []
synonym: "CMP catabolism" EXACT []
synonym: "CMP degradation" EXACT []
is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process
is_a: GO:0046035 ! CMP metabolic process

[Term]
id: GO:0006249
name: dCMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dCMP breakdown" EXACT []
synonym: "dCMP catabolism" EXACT []
synonym: "dCMP degradation" EXACT []
is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process
is_a: GO:0046063 ! dCMP metabolic process

[Term]
id: GO:0006250
name: CDP reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
is_obsolete: true
consider: GO:0051063

[Term]
id: GO:0006251
name: dCDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dCDP breakdown" EXACT []
synonym: "dCDP catabolism" EXACT []
synonym: "dCDP degradation" EXACT []
is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process
is_a: GO:0046062 ! dCDP metabolic process

[Term]
id: GO:0006252
name: CTP reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
is_obsolete: true
consider: GO:0051065

[Term]
id: GO:0006253
name: dCTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dCTP, deoxycytidine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dCTP breakdown" EXACT []
synonym: "dCTP catabolism" EXACT []
synonym: "dCTP degradation" EXACT []
is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0046065 ! dCTP metabolic process

[Term]
id: GO:0006254
name: CTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of CTP, cytidine 5'-triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "CTP breakdown" EXACT []
synonym: "CTP catabolism" EXACT []
synonym: "CTP degradation" EXACT []
synonym: "CTP hydrolysis" EXACT []
is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process
is_a: GO:0046036 ! CTP metabolic process

[Term]
id: GO:0006255
name: UDP reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
is_obsolete: true
consider: GO:0051062

[Term]
id: GO:0006256
name: UDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "UDP breakdown" EXACT []
synonym: "UDP catabolism" EXACT []
synonym: "UDP degradation" EXACT []
is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process
is_a: GO:0046048 ! UDP metabolic process

[Term]
id: GO:0006257
name: dUDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dUDP, deoxyuridine (5'-)diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dUDP breakdown" EXACT []
synonym: "dUDP catabolism" EXACT []
synonym: "dUDP degradation" EXACT []
is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process
is_a: GO:0046077 ! dUDP metabolic process

[Term]
id: GO:0006258
name: UDP-glucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-glucose breakdown" EXACT []
synonym: "UDP-glucose catabolism" EXACT []
synonym: "UDP-glucose degradation" EXACT []
is_a: GO:0006011 ! UDP-glucose metabolic process
is_a: GO:0009227 ! nucleotide-sugar catabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process

[Term]
id: GO:0006259
name: DNA metabolic process
namespace: biological_process
alt_id: GO:0055132
def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "cellular DNA metabolism" EXACT []
synonym: "DNA metabolism" EXACT []
is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0006260
name: DNA replication
namespace: biological_process
alt_id: GO:0055133
def: "The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'.
subset: goslim_pir
subset: goslim_pombe
subset: gosubset_prok
synonym: "DNA biosynthesis" RELATED []
synonym: "DNA biosynthetic process" RELATED []
synonym: "DNA synthesis" RELATED []
xref: Reactome:176101 "Recruitment of Rad17-RFC complex to DNA"
xref: Reactome:176116 "Recruitment and activation of Chk1"
xref: Reactome:176175 "Stalling of DNA replication fork and RPA binding"
xref: Reactome:176187 "Activation of ATR in response to replication stress"
xref: Reactome:176250 "Binding of ATR-ATRIP to the RPA-ssDNA complex"
xref: Reactome:176264 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA"
xref: Reactome:176298 "Activation of claspin"
xref: Reactome:176318 "Loading of claspin onto DNA during replication origin firing"
xref: Reactome:429125 "Activation of claspin"
xref: Reactome:433202 "Binding of ATR-ATRIP to the RPA-ssDNA complex"
xref: Reactome:442012 "Loading of claspin onto DNA during replication origin firing"
xref: Reactome:446069 "Recruitment and activation of Chk1"
xref: Reactome:446123 "Recruitment of Rad17-RFC complex to DNA"
xref: Reactome:446153 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA"
xref: Reactome:447074 "Stalling of DNA replication fork and RPA binding"
xref: Reactome:448696 "Activation of ATR in response to replication stress"
xref: Reactome:463715 "Loading of claspin onto DNA during replication origin firing"
xref: Reactome:467450 "Recruitment of Rad17-RFC complex to DNA"
xref: Reactome:467477 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA"
xref: Reactome:468344 "Stalling of DNA replication fork and RPA binding"
xref: Reactome:470298 "Activation of ATR in response to replication stress"
xref: Reactome:472164 "Activation of claspin"
xref: Reactome:475516 "Binding of ATR-ATRIP to the RPA-ssDNA complex"
xref: Reactome:482185 "Loading of claspin onto DNA during replication origin firing"
xref: Reactome:485413 "Recruitment and activation of Chk1"
xref: Reactome:485440 "Recruitment of Rad17-RFC complex to DNA"
xref: Reactome:485461 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA"
xref: Reactome:486163 "Stalling of DNA replication fork and RPA binding"
xref: Reactome:487512 "Activation of ATR in response to replication stress"
xref: Reactome:490390 "Activation of claspin"
xref: Reactome:502397 "Loading of claspin onto DNA during replication origin firing"
xref: Reactome:505179 "Recruitment and activation of Chk1"
xref: Reactome:507473 "Activation of ATR in response to replication stress"
xref: Reactome:514771 "Loading of claspin onto DNA during replication origin firing"
xref: Reactome:516172 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA"
xref: Reactome:517816 "Activation of ATR in response to replication stress"
xref: Reactome:525168 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA"
xref: Reactome:526692 "Activation of ATR in response to replication stress"
xref: Reactome:531467 "Activation of ATR in response to replication stress"
xref: Reactome:536852 "Activation of ATR in response to replication stress"
xref: Reactome:541523 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA"
xref: Reactome:542605 "Activation of ATR in response to replication stress"
xref: Reactome:546964 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA"
xref: Reactome:547923 "Activation of ATR in response to replication stress"
xref: Wikipedia:DNA_replication
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0034645 ! cellular macromolecule biosynthetic process

[Term]
id: GO:0006261
name: DNA-dependent DNA replication
namespace: biological_process
alt_id: GO:0006262
alt_id: GO:0006263
def: "The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0006260 ! DNA replication

[Term]
id: GO:0006264
name: mitochondrial DNA replication
namespace: biological_process
def: "The process whereby new strands of DNA are synthesized in the mitochondrion." [GOC:ai]
synonym: "mitochondrial DNA synthesis" RELATED []
synonym: "mtDNA replication" EXACT []
synonym: "mtDNA synthesis" RELATED []
synonym: "replication of mitochondrial DNA" EXACT []
is_a: GO:0006261 ! DNA-dependent DNA replication
is_a: GO:0032042 ! mitochondrial DNA metabolic process

[Term]
id: GO:0006265
name: DNA topological change
namespace: biological_process
def: "The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490]
comment: Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
subset: gosubset_prok
synonym: "DNA underwinding" NARROW []
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0071103 ! DNA conformation change

[Term]
id: GO:0006266
name: DNA ligation
namespace: biological_process
def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [ISBN:0815316194]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0006267
name: pre-replicative complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the pre-replicative complex, a protein-DNA complex that forms at eukaryotic DNA replication origins during late M phase; its presence is required for replication initiation." [GOC:mah]
synonym: "pre-replicative complex formation" EXACT []
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0006268
name: DNA unwinding during replication
namespace: biological_process
def: "The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194]
comment: Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'.
subset: gosubset_prok
synonym: "DNA unwinding factor" RELATED []
is_a: GO:0032508 ! DNA duplex unwinding
relationship: part_of GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0006269
name: DNA replication, synthesis of RNA primer
namespace: biological_process
def: "The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis." [PMID:11395402]
subset: gosubset_prok
synonym: "replication priming" RELATED []
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0032774 ! RNA biosynthetic process
relationship: part_of GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0006270
name: DNA replication initiation
namespace: biological_process
def: "The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action." [ISBN:071673706X, ISBN:0815316194]
subset: gosubset_prok
xref: Reactome:449288 "DNA replication initiation"
xref: Reactome:470407 "DNA replication initiation"
xref: Reactome:508054 "DNA replication initiation"
xref: Reactome:517908 "DNA replication initiation"
xref: Reactome:526736 "DNA replication initiation"
xref: Reactome:531500 "DNA replication initiation"
xref: Reactome:536891 "DNA replication initiation"
xref: Reactome:542639 "DNA replication initiation"
xref: Reactome:547956 "DNA replication initiation"
xref: Reactome:552528 "DNA replication initiation"
xref: Reactome:558150 "DNA replication initiation"
xref: Reactome:568780 "DNA replication initiation"
xref: Reactome:581983 "DNA replication initiation"
xref: Reactome:586033 "DNA replication initiation"
xref: Reactome:592889 "DNA replication initiation"
xref: Reactome:595590 "DNA replication initiation"
xref: Reactome:68952 "DNA replication initiation"
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0006271
name: DNA strand elongation during DNA replication
namespace: biological_process
def: "The process by which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand." [ISBN:071673706X, ISBN:0815316194]
subset: gosubset_prok
synonym: "DNA replication elongation" EXACT []
xref: Reactome:449110 "DNA strand elongation"
xref: Reactome:470222 "DNA strand elongation"
xref: Reactome:487959 "DNA strand elongation"
xref: Reactome:507875 "DNA strand elongation"
xref: Reactome:517773 "DNA strand elongation"
xref: Reactome:526608 "DNA strand elongation"
xref: Reactome:531400 "DNA strand elongation"
xref: Reactome:536780 "DNA strand elongation"
xref: Reactome:542531 "DNA strand elongation"
xref: Reactome:547856 "DNA strand elongation"
xref: Reactome:552432 "DNA strand elongation"
xref: Reactome:558044 "DNA strand elongation"
xref: Reactome:568692 "DNA strand elongation"
xref: Reactome:581895 "DNA strand elongation"
xref: Reactome:585961 "DNA strand elongation"
xref: Reactome:592796 "DNA strand elongation"
xref: Reactome:595524 "DNA strand elongation"
xref: Reactome:597423 "DNA strand elongation"
xref: Reactome:598195 "DNA strand elongation"
xref: Reactome:600667 "DNA strand elongation"
xref: Reactome:602576 "DNA strand elongation"
xref: Reactome:69190 "DNA strand elongation"
is_a: GO:0022616 ! DNA strand elongation
relationship: part_of GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0006272
name: leading strand elongation
namespace: biological_process
def: "The synthesis of DNA from a template strand in the 5' to 3' direction; leading strand elongation is continuous as it proceeds in the same direction as the replication fork." [ISBN:071673706X, ISBN:0815316194]
subset: gosubset_prok
is_a: GO:0006271 ! DNA strand elongation during DNA replication

[Term]
id: GO:0006273
name: lagging strand elongation
namespace: biological_process
def: "The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork." [ISBN:071673706X, ISBN:0815316194]
subset: gosubset_prok
is_a: GO:0006271 ! DNA strand elongation during DNA replication

[Term]
id: GO:0006274
name: DNA replication termination
namespace: biological_process
def: "The process by which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet." [GOC:mah, PMID:10209736, PMID:12009298]
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0006275
name: regulation of DNA replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0006260 ! DNA replication

[Term]
id: GO:0006276
name: plasmid maintenance
namespace: biological_process
def: "The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0006277
name: DNA amplification
namespace: biological_process
def: "The process by which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment." [ISBN:0721601464]
subset: gosubset_prok
is_a: GO:0006260 ! DNA replication

[Term]
id: GO:0006278
name: RNA-dependent DNA replication
namespace: biological_process
def: "The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: Reactome:162589 "Reverse Transcription of HIV RNA"
xref: Reactome:164516 "Minus-strand DNA synthesis"
xref: Reactome:164525 "Plus-strand DNA synthesis"
is_a: GO:0006260 ! DNA replication

[Term]
id: GO:0006279
name: premeiotic DNA synthesis
namespace: biological_process
def: "The replication of DNA that precedes meiotic cell division." [GOC:ai]
synonym: "meiotic DNA replication" EXACT []
synonym: "meiotic DNA synthesis" EXACT []
synonym: "premeiotic DNA replication" EXACT []
is_a: GO:0006260 ! DNA replication

[Term]
id: GO:0006280
name: mutagenesis
namespace: biological_process
def: "OBSOLETE. The process by which genetic material undergoes a detectable and heritable structural change. There are three categories of mutation: genome mutations, involving addition or subtraction of one or more whole chromosomes; chromosome mutations, which alter the structure of chromosomes; and gene mutations, where the structure of a gene is altered at the molecular level." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because mutagenesis is not a valid biological process in which gene products would normally participate. Rather, mutations arise from DNA replication errors or damage by an extrinsic agent.
subset: gosubset_prok
is_obsolete: true
consider: GO:0006281
consider: GO:0051276

[Term]
id: GO:0006281
name: DNA repair
namespace: biological_process
def: "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486]
subset: goslim_pir
subset: goslim_pombe
subset: gosubset_prok
xref: Reactome:448579 "DNA Repair"
xref: Reactome:449225 "DNA Damage Reversal"
xref: Reactome:469708 "DNA Repair"
xref: Reactome:470344 "DNA Damage Reversal"
xref: Reactome:487420 "DNA Repair"
xref: Reactome:488024 "DNA Damage Reversal"
xref: Reactome:507375 "DNA Repair"
xref: Reactome:507985 "DNA Damage Reversal"
xref: Reactome:517374 "DNA Repair"
xref: Reactome:526250 "DNA Repair"
xref: Reactome:531127 "DNA Repair"
xref: Reactome:536499 "DNA Repair"
xref: Reactome:542209 "DNA Repair"
xref: Reactome:542599 "DNA Damage Reversal"
xref: Reactome:547563 "DNA Repair"
xref: Reactome:552173 "DNA Repair"
xref: Reactome:557757 "DNA Repair"
xref: Reactome:558121 "DNA Damage Reversal"
xref: Reactome:568370 "DNA Repair"
xref: Reactome:568747 "DNA Damage Reversal"
xref: Reactome:581572 "DNA Repair"
xref: Reactome:581951 "DNA Damage Reversal"
xref: Reactome:585783 "DNA Repair"
xref: Reactome:592468 "DNA Repair"
xref: Reactome:595411 "DNA Repair"
xref: Reactome:597351 "DNA Repair"
xref: Reactome:598160 "DNA Repair"
xref: Reactome:599712 "DNA Repair"
xref: Reactome:600616 "DNA Repair"
xref: Reactome:600694 "DNA Damage Reversal"
xref: Reactome:602518 "DNA Repair"
xref: Reactome:602608 "DNA Damage Reversal"
xref: Reactome:73894 "DNA Repair"
xref: Reactome:73942 "DNA Damage Reversal"
xref: Wikipedia:DNA_repair
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0006974 ! response to DNA damage stimulus

[Term]
id: GO:0006282
name: regulation of DNA repair
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0051052 ! regulation of DNA metabolic process
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0006281 ! DNA repair

[Term]
id: GO:0006283
name: transcription-coupled nucleotide-excision repair
namespace: biological_process
def: "The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway." [PMID:10197977, PMID:11900249]
subset: gosubset_prok
synonym: "TC-NER" EXACT [PMID:10197977]
synonym: "TCR" RELATED [GOC:vw, PMID:18794354]
synonym: "transcription-coupled NER" EXACT [GOC:mah]
synonym: "transcription-coupled repair" EXACT [GOC:vw, PMID:18794354]
xref: Reactome:448577 "Transcription-coupled NER (TC-NER)"
xref: Reactome:469706 "Transcription-coupled NER (TC-NER)"
xref: Reactome:487418 "Transcription-coupled NER (TC-NER)"
xref: Reactome:507373 "Transcription-coupled NER (TC-NER)"
xref: Reactome:517372 "Transcription-coupled NER (TC-NER)"
xref: Reactome:526248 "Transcription-coupled NER (TC-NER)"
xref: Reactome:531125 "Transcription-coupled NER (TC-NER)"
xref: Reactome:536497 "Transcription-coupled NER (TC-NER)"
xref: Reactome:542207 "Transcription-coupled NER (TC-NER)"
xref: Reactome:547561 "Transcription-coupled NER (TC-NER)"
xref: Reactome:552171 "Transcription-coupled NER (TC-NER)"
xref: Reactome:557755 "Transcription-coupled NER (TC-NER)"
xref: Reactome:568368 "Transcription-coupled NER (TC-NER)"
xref: Reactome:581570 "Transcription-coupled NER (TC-NER)"
xref: Reactome:585781 "Transcription-coupled NER (TC-NER)"
xref: Reactome:592466 "Transcription-coupled NER (TC-NER)"
xref: Reactome:595513 "Transcription-coupled NER (TC-NER)"
xref: Reactome:597434 "Transcription-coupled NER (TC-NER)"
xref: Reactome:598208 "Transcription-coupled NER (TC-NER)"
xref: Reactome:600687 "Transcription-coupled NER (TC-NER)"
xref: Reactome:602593 "Transcription-coupled NER (TC-NER)"
xref: Reactome:73937 "Transcription-coupled NER (TC-NER)"
is_a: GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0006284
name: base-excision repair
namespace: biological_process
def: "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194]
subset: gosubset_prok
synonym: "BER" EXACT []
xref: Reactome:448807 "Base Excision Repair"
xref: Reactome:469923 "Base Excision Repair"
xref: Reactome:487778 "Base Excision Repair"
xref: Reactome:507585 "Base Excision Repair"
xref: Reactome:517555 "Base Excision Repair"
xref: Reactome:526422 "Base Excision Repair"
xref: Reactome:531313 "Base Excision Repair"
xref: Reactome:536696 "Base Excision Repair"
xref: Reactome:542429 "Base Excision Repair"
xref: Reactome:547778 "Base Excision Repair"
xref: Reactome:552265 "Base Excision Repair"
xref: Reactome:557884 "Base Excision Repair"
xref: Reactome:568482 "Base Excision Repair"
xref: Reactome:581693 "Base Excision Repair"
xref: Reactome:585838 "Base Excision Repair"
xref: Reactome:592600 "Base Excision Repair"
xref: Reactome:595410 "Base Excision Repair"
xref: Reactome:597350 "Base Excision Repair"
xref: Reactome:598167 "Base Excision Repair"
xref: Reactome:599711 "Base Excision Repair"
xref: Reactome:600615 "Base Excision Repair"
xref: Reactome:602517 "Base Excision Repair"
xref: Reactome:73884 "Base Excision Repair"
xref: Wikipedia:Base_excision_repair
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006285
name: base-excision repair, AP site formation
namespace: biological_process
def: "The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired." [ISBN:0815316194]
subset: gosubset_prok
xref: Reactome:448968 "Base-Excision Repair, AP Site Formation"
xref: Reactome:470088 "Base-Excision Repair, AP Site Formation"
xref: Reactome:487777 "Base-Excision Repair, AP Site Formation"
xref: Reactome:507742 "Base-Excision Repair, AP Site Formation"
xref: Reactome:517674 "Base-Excision Repair, AP Site Formation"
xref: Reactome:526509 "Base-Excision Repair, AP Site Formation"
xref: Reactome:531312 "Base-Excision Repair, AP Site Formation"
xref: Reactome:536695 "Base-Excision Repair, AP Site Formation"
xref: Reactome:542428 "Base-Excision Repair, AP Site Formation"
xref: Reactome:547777 "Base-Excision Repair, AP Site Formation"
xref: Reactome:552337 "Base-Excision Repair, AP Site Formation"
xref: Reactome:557943 "Base-Excision Repair, AP Site Formation"
xref: Reactome:568578 "Base-Excision Repair, AP Site Formation"
xref: Reactome:581784 "Base-Excision Repair, AP Site Formation"
xref: Reactome:585893 "Base-Excision Repair, AP Site Formation"
xref: Reactome:592699 "Base-Excision Repair, AP Site Formation"
xref: Reactome:595449 "Base-Excision Repair, AP Site Formation"
xref: Reactome:597384 "Base-Excision Repair, AP Site Formation"
xref: Reactome:598166 "Base-Excision Repair, AP Site Formation"
xref: Reactome:599729 "Base-Excision Repair, AP Site Formation"
xref: Reactome:600631 "Base-Excision Repair, AP Site Formation"
xref: Reactome:602532 "Base-Excision Repair, AP Site Formation"
xref: Reactome:73929 "Base-Excision Repair, AP Site Formation"
is_a: GO:0006308 ! DNA catabolic process
relationship: part_of GO:0006284 ! base-excision repair

[Term]
id: GO:0006286
name: base-excision repair, base-free sugar-phosphate removal
namespace: biological_process
def: "Excision of the sugar phosphate residue at an AP site, i.e. a deoxyribose sugar with a missing base, by a phosphodiesterase enzyme." [ISBN:0815316194]
subset: gosubset_prok
xref: Reactome:110375 "Excision of the abasic sugar phosphate (dRP) residue at the strand break"
xref: Reactome:437839 "Excision of the abasic sugar phosphate (dRP) residue at the strand break"
xref: Reactome:459961 "Excision of the abasic sugar phosphate (dRP) residue at the strand break"
xref: Reactome:498883 "Excision of the abasic sugar phosphate (dRP) residue at the strand break"
xref: Reactome:589800 "Excision of the abasic sugar phosphate (dRP) residue at the strand break"
xref: Reactome:601729 "Excision of the abasic sugar phosphate (dRP) residue at the strand break"
is_a: GO:0006308 ! DNA catabolic process
is_a: GO:0016311 ! dephosphorylation
relationship: part_of GO:0006284 ! base-excision repair

[Term]
id: GO:0006287
name: base-excision repair, gap-filling
namespace: biological_process
def: "Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template." [ISBN:1550091131]
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006284 ! base-excision repair

[Term]
id: GO:0006288
name: base-excision repair, DNA ligation
namespace: biological_process
def: "The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair." [ISBN:1550091131]
subset: gosubset_prok
xref: Reactome:110370 "Ligation of DNA at sites of patch replacement"
xref: Reactome:437059 "DNA ligation via the single-nucleotide replacement pathway"
xref: Reactome:441837 "Ligation of DNA at sites of patch replacement"
xref: Reactome:459301 "DNA ligation via the single-nucleotide replacement pathway"
xref: Reactome:463550 "Ligation of DNA at sites of patch replacement"
xref: Reactome:498324 "DNA ligation via the single-nucleotide replacement pathway"
xref: Reactome:502313 "Ligation of DNA at sites of patch replacement"
xref: Reactome:540726 "Ligation of DNA at sites of patch replacement"
xref: Reactome:546326 "Ligation of DNA at sites of patch replacement"
xref: Reactome:551078 "Ligation of DNA at sites of patch replacement"
xref: Reactome:566011 "Ligation of DNA at sites of patch replacement"
xref: Reactome:578838 "Ligation of DNA at sites of patch replacement"
xref: Reactome:589634 "DNA ligation via the single-nucleotide replacement pathway"
xref: Reactome:73931 "DNA ligation via the single-nucleotide replacement pathway"
is_a: GO:0051103 ! DNA ligation during DNA repair
relationship: part_of GO:0006284 ! base-excision repair

[Term]
id: GO:0006289
name: nucleotide-excision repair
namespace: biological_process
alt_id: GO:0045001
def: "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]
comment: Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair.
subset: gosubset_prok
synonym: "interstrand crosslink repair" NARROW []
synonym: "intrastrand cross-link repair" RELATED []
synonym: "NER" EXACT []
synonym: "pyrimidine-dimer repair, DNA damage excision" EXACT []
xref: Reactome:448578 "Nucleotide Excision Repair"
xref: Reactome:469707 "Nucleotide Excision Repair"
xref: Reactome:487419 "Nucleotide Excision Repair"
xref: Reactome:507374 "Nucleotide Excision Repair"
xref: Reactome:517373 "Nucleotide Excision Repair"
xref: Reactome:526249 "Nucleotide Excision Repair"
xref: Reactome:531126 "Nucleotide Excision Repair"
xref: Reactome:536498 "Nucleotide Excision Repair"
xref: Reactome:542208 "Nucleotide Excision Repair"
xref: Reactome:547562 "Nucleotide Excision Repair"
xref: Reactome:552172 "Nucleotide Excision Repair"
xref: Reactome:557756 "Nucleotide Excision Repair"
xref: Reactome:568369 "Nucleotide Excision Repair"
xref: Reactome:581571 "Nucleotide Excision Repair"
xref: Reactome:585782 "Nucleotide Excision Repair"
xref: Reactome:592467 "Nucleotide Excision Repair"
xref: Reactome:595514 "Nucleotide Excision Repair"
xref: Reactome:597432 "Nucleotide Excision Repair"
xref: Reactome:598206 "Nucleotide Excision Repair"
xref: Reactome:600685 "Nucleotide Excision Repair"
xref: Reactome:602591 "Nucleotide Excision Repair"
xref: Reactome:73885 "Nucleotide Excision Repair"
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006290
name: pyrimidine dimer repair
namespace: biological_process
def: "The repair of UV-induced T-T, C-T and C-C dimers." [ISBN:0815316194]
subset: gosubset_prok
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006291
name: pyrimidine-dimer repair, DNA damage excision
namespace: biological_process
def: "OBSOLETE. The excision of damaged DNA during pyrimidine-dimer repair. A large multienzyme complex scans the DNA for a distortion in the double helix rather than for a specific base change. Once a bulky lesion is found, the phosphodiester backbone of the abnormal strand is cleaved on both sides of the distortion, and the portion of the strand containing the lesion (an oligonucleotide) is peeled away from the DNA double helix by a DNA helicase enzyme." [ISBN:0815316194]
comment: This term was made obsolete because this process can be subdivided into multiple processes.
is_obsolete: true
consider: GO:0006289

[Term]
id: GO:0006292
name: pyrimidine-dimer repair, DNA damage recognition
namespace: biological_process
def: "OBSOLETE. The location of pyrimidine dimers by a large multienzyme complex that scans the DNA for distortions in the double helix caused by pyrimidine dimers." [ISBN:0815316194]
comment: This term was made obsolete because it is a substrate specific DNA repair process.
is_obsolete: true
consider: GO:0000715
consider: GO:0000716

[Term]
id: GO:0006293
name: nucleotide-excision repair, preincision complex stabilization
namespace: biological_process
def: "The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977]
subset: gosubset_prok
xref: Reactome:109953 "Binding of ERCC1-XPF to preincision complex"
xref: Reactome:433206 "Binding of ERCC1-XPF to preincision complex"
xref: Reactome:455768 "Binding of ERCC1-XPF to preincision complex"
xref: Reactome:494643 "Binding of ERCC1-XPF to preincision complex"
xref: Reactome:511428 "Binding of ERCC1-XPF to preincision complex"
xref: Reactome:520717 "Binding of ERCC1-XPF to preincision complex"
xref: Reactome:533529 "Binding of ERCC1-XPF to preincision complex"
xref: Reactome:538885 "Binding of ERCC1-XPF to preincision complex"
xref: Reactome:544675 "Binding of ERCC1-XPF to preincision complex"
xref: Reactome:549610 "Binding of ERCC1-XPF to preincision complex"
xref: Reactome:554576 "Binding of ERCC1-XPF to preincision complex"
xref: Reactome:562251 "Binding of ERCC1-XPF to preincision complex"
xref: Reactome:573866 "Binding of ERCC1-XPF to preincision complex"
xref: Reactome:588420 "Binding of ERCC1-XPF to preincision complex"
is_a: GO:0031334 ! positive regulation of protein complex assembly
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0006294
name: nucleotide-excision repair, preincision complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977]
subset: gosubset_prok
synonym: "nucleotide-excision repair, preincision complex formation" EXACT []
xref: Reactome:446124 "Recruitment of repair factors to form preincision complex"
xref: Reactome:467451 "Recruitment of repair factors to form preincision complex"
xref: Reactome:485441 "Recruitment of repair factors to form preincision complex"
xref: Reactome:73936 "Recruitment of repair factors to form preincision complex"
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0006295
name: nucleotide-excision repair, DNA incision, 3'-to lesion
namespace: biological_process
def: "The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage." [GOC:elh, PMID:10197977]
subset: gosubset_prok
synonym: "nucleotide-excision repair, DNA incision, 3' to lesion" EXACT []
xref: Reactome:427710 "3'- incision of DNA by XPG in GG-NER"
xref: Reactome:450067 "3'- incision of DNA by XPG in GG-NER"
xref: Reactome:471109 "3'- incision of DNA by XPG in GG-NER"
xref: Reactome:489028 "3'- incision of DNA by XPG in GG-NER"
xref: Reactome:508579 "3'- incision of DNA by XPG in GG-NER"
xref: Reactome:518414 "3'- incision of DNA by XPG in GG-NER"
xref: Reactome:527027 "3'- incision of DNA by XPG in GG-NER"
xref: Reactome:531800 "3'- incision of DNA by XPG in GG-NER"
xref: Reactome:537232 "3'- incision of DNA by XPG in GG-NER"
xref: Reactome:542916 "3'- incision of DNA by XPG in GG-NER"
xref: Reactome:548282 "3'- incision of DNA by XPG in GG-NER"
xref: Reactome:552915 "3'- incision of DNA by XPG in GG-NER"
xref: Reactome:558770 "3'- incision of DNA by XPG in GG-NER"
xref: Reactome:569656 "3'- incision of DNA by XPG in GG-NER"
xref: Reactome:586446 "3'- incision of DNA by XPG in GG-NER"
xref: Reactome:73938 "3'- incision of DNA by XPG in GG-NER"
is_a: GO:0033683 ! nucleotide-excision repair, DNA incision

[Term]
id: GO:0006296
name: nucleotide-excision repair, DNA incision, 5'-to lesion
namespace: biological_process
def: "The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage." [GOC:elh, PMID:10197977]
subset: gosubset_prok
synonym: "nucleotide-excision repair, DNA incision, 5' to lesion" EXACT []
xref: Reactome:427892 "5'-incision of DNA by ERCC1-XPF in GG-NER"
xref: Reactome:450252 "5'-incision of DNA by ERCC1-XPF in GG-NER"
xref: Reactome:73939 "5'-incision of DNA by ERCC1-XPF in GG-NER"
is_a: GO:0033683 ! nucleotide-excision repair, DNA incision

[Term]
id: GO:0006297
name: nucleotide-excision repair, DNA gap filling
namespace: biological_process
def: "Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes." [ISBN:0815316194]
subset: gosubset_prok
xref: Reactome:449178 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:470291 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:487971 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:507942 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:517813 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:526645 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:531443 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:536818 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:542574 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:547898 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:552474 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:558085 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:568729 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:581932 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:585968 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:592825 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:595546 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:597430 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:598204 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:600683 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:602589 "Gap-filling DNA repair synthesis and ligation in GG-NER"
xref: Reactome:74969 "Gap-filling DNA repair synthesis and ligation in GG-NER"
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0006298
name: mismatch repair
namespace: biological_process
alt_id: GO:0006300
def: "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11687886]
subset: gosubset_prok
synonym: "long patch mismatch repair system" NARROW []
synonym: "mismatch repair, MutL-like pathway" RELATED []
synonym: "MMR" EXACT []
synonym: "MutS/MutL/MutH pathway" RELATED []
xref: Wikipedia:DNA_mismatch_repair
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006299
name: short patch mismatch repair system
namespace: biological_process
def: "OBSOLETE. The repair of mismatched DNA where the gap to be repaired is only one nucleotide. DNA polymerase is the preferred polymerase in short patch repair, performing gap filling DNA synthesis and removal of the 5'-deoxyribose phosphate of the abasic site." [PMID:10660619, PMID:10878254]
comment: This term was made obsolete because 'short patch' is a relative statement, often used ambiguously, and does not necessarily represent a process; the processes it can stand for are base excision repair, nucleotide excision repair, transcription-coupled nucleotide excision repair, and mismatch repair.
is_obsolete: true
consider: GO:0006284
consider: GO:0006289

[Term]
id: GO:0006301
name: postreplication repair
namespace: biological_process
def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh]
subset: gosubset_prok
xref: Wikipedia:Postreplication_repair
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006302
name: double-strand break repair
namespace: biological_process
def: "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh]
subset: gosubset_prok
xref: Reactome:448608 "Double-Strand Break Repair"
xref: Reactome:469737 "Double-Strand Break Repair"
xref: Reactome:487647 "Double-Strand Break Repair"
xref: Reactome:507607 "Double-Strand Break Repair"
xref: Reactome:517589 "Double-Strand Break Repair"
xref: Reactome:526443 "Double-Strand Break Repair"
xref: Reactome:531250 "Double-Strand Break Repair"
xref: Reactome:536624 "Double-Strand Break Repair"
xref: Reactome:542351 "Double-Strand Break Repair"
xref: Reactome:547695 "Double-Strand Break Repair"
xref: Reactome:552289 "Double-Strand Break Repair"
xref: Reactome:557905 "Double-Strand Break Repair"
xref: Reactome:568506 "Double-Strand Break Repair"
xref: Reactome:581717 "Double-Strand Break Repair"
xref: Reactome:585851 "Double-Strand Break Repair"
xref: Reactome:592613 "Double-Strand Break Repair"
xref: Reactome:595426 "Double-Strand Break Repair"
xref: Reactome:597361 "Double-Strand Break Repair"
xref: Reactome:598159 "Double-Strand Break Repair"
xref: Reactome:600682 "Double-Strand Break Repair"
xref: Reactome:602588 "Double-Strand Break Repair"
xref: Reactome:73890 "Double-Strand Break Repair"
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006303
name: double-strand break repair via nonhomologous end joining
namespace: biological_process
def: "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends." [PMID:10827453]
subset: gosubset_prok
synonym: "NHEJ" EXACT []
xref: Reactome:448826 "Nonhomologous End-joining (NHEJ)"
xref: Reactome:469942 "Nonhomologous End-joining (NHEJ)"
xref: Reactome:487648 "Nonhomologous End-joining (NHEJ)"
xref: Reactome:507606 "Nonhomologous End-joining (NHEJ)"
xref: Reactome:517590 "Nonhomologous End-joining (NHEJ)"
xref: Reactome:526442 "Nonhomologous End-joining (NHEJ)"
xref: Reactome:531249 "Nonhomologous End-joining (NHEJ)"
xref: Reactome:536623 "Nonhomologous End-joining (NHEJ)"
xref: Reactome:542350 "Nonhomologous End-joining (NHEJ)"
xref: Reactome:547694 "Nonhomologous End-joining (NHEJ)"
xref: Reactome:568507 "Nonhomologous End-joining (NHEJ)"
xref: Reactome:581718 "Nonhomologous End-joining (NHEJ)"
xref: Reactome:592612 "Nonhomologous End-joining (NHEJ)"
xref: Reactome:73889 "Nonhomologous End-joining (NHEJ)"
is_a: GO:0000726 ! non-recombinational repair
is_a: GO:0006302 ! double-strand break repair

[Term]
id: GO:0006304
name: DNA modification
namespace: biological_process
def: "The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties." [GOC:jl, GOC:ma]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0043412 ! macromolecule modification

[Term]
id: GO:0006305
name: DNA alkylation
namespace: biological_process
def: "The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis." [ISBN:0716735970]
subset: gosubset_prok
is_a: GO:0006304 ! DNA modification

[Term]
id: GO:0006306
name: DNA methylation
namespace: biological_process
def: "The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: Wikipedia:DNA_methylation
is_a: GO:0006305 ! DNA alkylation
is_a: GO:0040029 ! regulation of gene expression, epigenetic
is_a: GO:0043414 ! macromolecule methylation

[Term]
id: GO:0006307
name: DNA dealkylation
namespace: biological_process
def: "The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT)." [PMID:10946226]
subset: gosubset_prok
xref: Reactome:112122 "ABH2 mediated Reversal of Alkylation Damage"
xref: Reactome:112126 "ABH3 mediated Reversal of Alkylation Damage"
xref: Reactome:449223 "ABH2 mediated Reversal of Alkylation Damage"
xref: Reactome:449224 "Reversal of Alkylation Damage By DNA Dioxygenases"
xref: Reactome:449226 "ABH3 mediated Reversal of Alkylation Damage"
xref: Reactome:470342 "ABH2 mediated Reversal of Alkylation Damage"
xref: Reactome:470343 "Reversal of Alkylation Damage By DNA Dioxygenases"
xref: Reactome:470345 "ABH3 mediated Reversal of Alkylation Damage"
xref: Reactome:488022 "ABH2 mediated Reversal of Alkylation Damage"
xref: Reactome:488023 "Reversal of Alkylation Damage By DNA Dioxygenases"
xref: Reactome:488025 "ABH3 mediated Reversal of Alkylation Damage"
xref: Reactome:507983 "ABH2 mediated Reversal of Alkylation Damage"
xref: Reactome:507984 "Reversal of Alkylation Damage By DNA Dioxygenases"
xref: Reactome:507986 "ABH3 mediated Reversal of Alkylation Damage"
xref: Reactome:542597 "ABH2 mediated Reversal of Alkylation Damage"
xref: Reactome:542598 "Reversal of Alkylation Damage By DNA Dioxygenases"
xref: Reactome:558119 "ABH2 mediated Reversal of Alkylation Damage"
xref: Reactome:558120 "Reversal of Alkylation Damage By DNA Dioxygenases"
xref: Reactome:558122 "ABH3 mediated Reversal of Alkylation Damage"
xref: Reactome:568745 "ABH3 mediated Reversal of Alkylation Damage"
xref: Reactome:568746 "Reversal of Alkylation Damage By DNA Dioxygenases"
xref: Reactome:581949 "ABH3 mediated Reversal of Alkylation Damage"
xref: Reactome:581950 "Reversal of Alkylation Damage By DNA Dioxygenases"
xref: Reactome:600692 "ABH2 mediated Reversal of Alkylation Damage"
xref: Reactome:600693 "Reversal of Alkylation Damage By DNA Dioxygenases"
xref: Reactome:602606 "ABH3 mediated Reversal of Alkylation Damage"
xref: Reactome:602607 "Reversal of Alkylation Damage By DNA Dioxygenases"
xref: Reactome:73892 "MGMT/hAGT mediated DNA Damage Reversal"
xref: Reactome:73943 "Reversal of Alkylation Damage By DNA Dioxygenases"
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0006308
name: DNA catabolic process
namespace: biological_process
def: "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "DNA breakdown" EXACT []
synonym: "DNA catabolism" EXACT []
synonym: "DNA degradation" EXACT []
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0044265 ! cellular macromolecule catabolic process

[Term]
id: GO:0006309
name: DNA fragmentation involved in apoptosis
namespace: biological_process
alt_id: GO:0008178
def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:mah, ISBN:0721639976]
synonym: "DNA catabolic process during apoptosis" EXACT []
synonym: "DNA catabolism during apoptosis" EXACT []
synonym: "DNA fragmentation" BROAD []
synonym: "endonucleolytic DNA catabolic process involved in apoptosis" EXACT []
xref: Reactome:140342 "Apoptosis induced DNA fragmentation"
xref: Reactome:448840 "Apoptosis induced DNA fragmentation"
xref: Reactome:469956 "Apoptosis induced DNA fragmentation"
xref: Reactome:487664 "Apoptosis induced DNA fragmentation"
xref: Reactome:507617 "Apoptosis induced DNA fragmentation"
xref: Reactome:517582 "Apoptosis induced DNA fragmentation"
is_a: GO:0000737 ! DNA catabolic process, endonucleolytic
is_a: GO:0006921 ! cell structure disassembly during apoptosis
relationship: part_of GO:0030262 ! apoptotic nuclear changes

[Term]
id: GO:0006310
name: DNA recombination
namespace: biological_process
def: "Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pombe
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0006311
name: meiotic gene conversion
namespace: biological_process
def: "The cell cycle process whereby genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele." [ISBN:0815316194]
synonym: "gene conversion without reciprocal crossover" EXACT []
is_a: GO:0006310 ! DNA recombination
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0006312
name: mitotic recombination
namespace: biological_process
def: "The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles." [GOC:elh]
xref: Wikipedia:Mitotic_crossover
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0006313
name: transposition, DNA-mediated
namespace: biological_process
alt_id: GO:0006317
alt_id: GO:0006318
def: "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:1555812090]
subset: gosubset_prok
synonym: "Class II transposition" EXACT []
synonym: "cut-and-paste transposition" EXACT []
synonym: "DNA transposition" EXACT [GOC:dph]
synonym: "P-element excision" NARROW []
synonym: "P-element transposition" NARROW []
synonym: "Tc1/mariner transposition" NARROW []
synonym: "Tc3 transposition" NARROW []
is_a: GO:0006310 ! DNA recombination
is_a: GO:0032196 ! transposition

[Term]
id: GO:0006314
name: intron homing
namespace: biological_process
def: "Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron." [PMID:10487208]
subset: gosubset_prok
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0006315
name: homing of group II introns
namespace: biological_process
def: "Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure." [GOC:mcc, ISBN:0716743663, PMID:10487208]
subset: gosubset_prok
is_a: GO:0006314 ! intron homing

[Term]
id: GO:0006316
name: movement of group I intron
namespace: biological_process
def: "Lateral transfer of a group I intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group I introns are self-splicing introns that use guanosine as a cofactor in the splicing reaction." [GOC:mcc, ISBN:0716743663, PMID:10487208]
subset: gosubset_prok
is_a: GO:0006314 ! intron homing

[Term]
id: GO:0006323
name: DNA packaging
namespace: biological_process
def: "Any process by which DNA and associated proteins are formed into a compact, orderly structure." [GOC:mah, ISBN:0815316194]
subset: goslim_pir
synonym: "DNA organisation" EXACT [GOC:curators]
synonym: "DNA organization" EXACT [GOC:curators]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0071103 ! DNA conformation change

[Term]
id: GO:0006324
name: S-phase-specific histone modification
namespace: biological_process
def: "The covalent alteration of one or more amino acid residues within a histone protein that takes place during, and results in a modification pattern characteristic of, S phase of the cell cycle." [GOC:mah, PMID:9990026]
is_a: GO:0016570 ! histone modification
relationship: part_of GO:0051320 ! S phase

[Term]
id: GO:0006325
name: chromatin organization
namespace: biological_process
def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah]
synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0006326
name: bent DNA binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
is_obsolete: true
replaced_by: GO:0003681

[Term]
id: GO:0006327
name: random coil binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
is_obsolete: true
consider: GO:0003695

[Term]
id: GO:0006328
name: AT binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
is_obsolete: true
replaced_by: GO:0003680

[Term]
id: GO:0006329
name: satellite DNA binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
is_obsolete: true
replaced_by: GO:0003696

[Term]
id: GO:0006330
name: single-stranded DNA binding
namespace: biological_process
alt_id: GO:0006331
alt_id: GO:0006332
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
is_obsolete: true
replaced_by: GO:0003697

[Term]
id: GO:0006333
name: chromatin assembly or disassembly
namespace: biological_process
def: "The formation or destruction of chromatin structures." [GOC:mah]
synonym: "chromatin assembly/disassembly" EXACT []
is_a: GO:0006325 ! chromatin organization

[Term]
id: GO:0006334
name: nucleosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
synonym: "histone chaperone" RELATED [GOC:vw]
synonym: "nucleosome modeling" EXACT []
is_a: GO:0034728 ! nucleosome organization
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0031497 ! chromatin assembly

[Term]
id: GO:0006335
name: DNA replication-dependent nucleosome assembly
namespace: biological_process
def: "The formation of nucleosomes on newly replicated DNA, coupled to strand elongation." [GOC:mah]
is_a: GO:0006334 ! nucleosome assembly
is_a: GO:0034723 ! DNA replication-dependent nucleosome organization

[Term]
id: GO:0006336
name: DNA replication-independent nucleosome assembly
namespace: biological_process
def: "The formation of nucleosomes outside the context of DNA replication." [GOC:mah]
synonym: "transcription-coupled nucleosome assembly" EXACT []
is_a: GO:0006334 ! nucleosome assembly
is_a: GO:0034724 ! DNA replication-independent nucleosome organization

[Term]
id: GO:0006337
name: nucleosome disassembly
namespace: biological_process
def: "The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah]
is_a: GO:0032986 ! protein-DNA complex disassembly
is_a: GO:0034728 ! nucleosome organization
relationship: part_of GO:0031498 ! chromatin disassembly

[Term]
id: GO:0006338
name: chromatin remodeling
namespace: biological_process
def: "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jic, PMID:12697820]
synonym: "chromatin modeling" EXACT []
synonym: "chromatin modelling" EXACT []
synonym: "chromatin remodelling" EXACT []
is_a: GO:0016568 ! chromatin modification

[Term]
id: GO:0006339
name: positive regulation of transcription of homeotic gene (trithorax group)
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
is_obsolete: true
consider: GO:0006342
consider: GO:0048096

[Term]
id: GO:0006340
name: negative regulation of transcription of homeotic gene (Polycomb group)
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
is_obsolete: true
consider: GO:0006342
consider: GO:0048096

[Term]
id: GO:0006341
name: chromatin insulator sequence binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
is_obsolete: true
replaced_by: GO:0043035

[Term]
id: GO:0006342
name: chromatin silencing
namespace: biological_process
alt_id: GO:0016440
def: "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245]
comment: Note that this process is the opposite of chromatin-mediated maintenance of transcription. This regulation is exemplified by members of the Polycomb group, which maintain the inactive state of homeotic gene transcription.
synonym: "chromatin-mediated maintenance of transcriptional inactivation" EXACT []
synonym: "chromatin-mediated silencing" EXACT []
synonym: "heterochromatic silencing" RELATED []
synonym: "TGS" EXACT []
synonym: "transcriptional gene silencing" EXACT []
is_a: GO:0016458 ! gene silencing
is_a: GO:0045814 ! negative regulation of gene expression, epigenetic
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent

[Term]
id: GO:0006343
name: establishment of chromatin silencing
namespace: biological_process
def: "The initial formation of a transcriptionally silent chromatin structure such as heterochromatin." [GOC:mah]
synonym: "establishment of heterochromatic silencing" RELATED []
is_a: GO:0006338 ! chromatin remodeling
relationship: part_of GO:0006342 ! chromatin silencing

[Term]
id: GO:0006344
name: maintenance of chromatin silencing
namespace: biological_process
def: "The maintenance of chromatin in a transciptionally silent state such as heterochromatin." [GOC:mah]
synonym: "maintenance of heterochromatic silencing" RELATED []
is_a: GO:0051276 ! chromosome organization
relationship: part_of GO:0006342 ! chromatin silencing

[Term]
id: GO:0006345
name: loss of chromatin silencing
namespace: biological_process
def: "The process leading to expression of genes that are typically not expressed due to silencing by regulatory proteins." [GOC:go_curators]
is_a: GO:0031936 ! negative regulation of chromatin silencing

[Term]
id: GO:0006346
name: methylation-dependent chromatin silencing
namespace: biological_process
def: "Repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:mah]
synonym: "methylation-dependent heterochromatic silencing" EXACT []
is_a: GO:0006342 ! chromatin silencing
is_a: GO:0016569 ! covalent chromatin modification

[Term]
id: GO:0006348
name: chromatin silencing at telomere
namespace: biological_process
def: "Repression of transcription of telomeric DNA by altering the structure of chromatin." [PMID:10219245]
synonym: "heterochromatic silencing at telomere" EXACT []
is_a: GO:0006342 ! chromatin silencing

[Term]
id: GO:0006349
name: regulation of gene expression by genetic imprinting
namespace: biological_process
def: "Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself." [GOC:ems, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11498578]
synonym: "regulation of gene expression by DNA imprinting" EXACT [GOC:mah]
xref: Wikipedia:Genomic_imprinting
is_a: GO:0040029 ! regulation of gene expression, epigenetic
is_a: GO:0071514 ! genetic imprinting

[Term]
id: GO:0006350
name: transcription
namespace: biological_process
alt_id: GO:0061018
def: "The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "cellular transcription" EXACT []
xref: Reactome:448636 "Transcription"
xref: Reactome:469764 "Transcription"
xref: Reactome:487521 "Transcription"
xref: Reactome:507482 "Transcription"
xref: Reactome:517466 "Transcription"
xref: Reactome:526339 "Transcription"
xref: Reactome:531172 "Transcription"
xref: Reactome:536547 "Transcription"
xref: Reactome:542268 "Transcription"
xref: Reactome:547614 "Transcription"
xref: Reactome:552218 "Transcription"
xref: Reactome:557808 "Transcription"
xref: Reactome:568425 "Transcription"
xref: Reactome:581627 "Transcription"
xref: Reactome:585958 "Transcription"
xref: Reactome:592524 "Transcription"
xref: Reactome:595359 "Transcription"
xref: Reactome:74159 "Transcription"
xref: Wikipedia:Transcription_(genetics)
is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
relationship: part_of GO:0010467 ! gene expression

[Term]
id: GO:0006351
name: transcription, DNA-dependent
namespace: biological_process
alt_id: GO:0061022
def: "The cellular synthesis of RNA on a template of DNA." [GOC:jl]
subset: gosubset_prok
synonym: "cellular transcription, DNA-dependent" EXACT []
is_a: GO:0006350 ! transcription
is_a: GO:0032774 ! RNA biosynthetic process

[Term]
id: GO:0006352
name: transcription initiation
namespace: biological_process
def: "Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter." [GOC:jic]
subset: gosubset_prok
synonym: "RNA polymerase complex assembly at promoter" EXACT []
is_a: GO:0006461 ! protein complex assembly
relationship: part_of GO:0006351 ! transcription, DNA-dependent

[Term]
id: GO:0006353
name: transcription termination
namespace: biological_process
def: "The process by which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [ISBN:0716720094]
subset: gosubset_prok
synonym: "transcriptional complex disassembly" EXACT []
is_a: GO:0043624 ! cellular protein complex disassembly
relationship: part_of GO:0006351 ! transcription, DNA-dependent

[Term]
id: GO:0006354
name: RNA elongation
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "transcription elongation" BROAD []
synonym: "transcriptional elongation" BROAD []
is_a: GO:0016070 ! RNA metabolic process
relationship: part_of GO:0006351 ! transcription, DNA-dependent

[Term]
id: GO:0006355
name: regulation of transcription, DNA-dependent
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of cellular transcription, DNA-dependent" EXACT []
synonym: "transcriptional control" BROAD []
is_a: GO:0045449 ! regulation of transcription
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: regulates GO:0006351 ! transcription, DNA-dependent

[Term]
id: GO:0006356
name: regulation of transcription from RNA polymerase I promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter." [GOC:go_curators]
synonym: "regulation of transcription from Pol I promoter" EXACT []
is_a: GO:0006355 ! regulation of transcription, DNA-dependent
relationship: regulates GO:0006360 ! transcription from RNA polymerase I promoter

[Term]
id: GO:0006357
name: regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators]
synonym: "regulation of transcription from Pol II promoter" EXACT []
is_a: GO:0006355 ! regulation of transcription, DNA-dependent
relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter

[Term]
id: GO:0006358
name: regulation of transcription from RNA polymerase II promoter, global
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of global transcription from Pol II promoter." [GOC:go_curators]
synonym: "global transcription regulation from Pol II promoter" EXACT []
synonym: "regulation of global transcription from Pol II promoter" EXACT []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter

[Term]
id: GO:0006359
name: regulation of transcription from RNA polymerase III promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter." [GOC:go_curators]
synonym: "regulation of transcription from Pol III promoter" EXACT []
is_a: GO:0006355 ! regulation of transcription, DNA-dependent
relationship: regulates GO:0006383 ! transcription from RNA polymerase III promoter

[Term]
id: GO:0006360
name: transcription from RNA polymerase I promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase I (Pol I), originating at a Pol I-specific promoter." [GOC:jl]
synonym: "transcription from Pol I promoter" EXACT []
xref: Reactome:448635 "RNA Polymerase I Transcription"
xref: Reactome:469763 "RNA Polymerase I Transcription"
xref: Reactome:487643 "RNA Polymerase I Transcription"
xref: Reactome:507603 "RNA Polymerase I Transcription"
xref: Reactome:517634 "RNA Polymerase I Transcription"
xref: Reactome:526434 "RNA Polymerase I Transcription"
xref: Reactome:531277 "RNA Polymerase I Transcription"
xref: Reactome:536621 "RNA Polymerase I Transcription"
xref: Reactome:542346 "RNA Polymerase I Transcription"
xref: Reactome:547687 "RNA Polymerase I Transcription"
xref: Reactome:552272 "RNA Polymerase I Transcription"
xref: Reactome:557896 "RNA Polymerase I Transcription"
xref: Reactome:568494 "RNA Polymerase I Transcription"
xref: Reactome:581705 "RNA Polymerase I Transcription"
xref: Reactome:592611 "RNA Polymerase I Transcription"
xref: Reactome:595418 "RNA Polymerase I Transcription"
xref: Reactome:73864 "RNA Polymerase I Transcription"
is_a: GO:0006351 ! transcription, DNA-dependent

[Term]
id: GO:0006361
name: transcription initiation from RNA polymerase I promoter
namespace: biological_process
def: "A transcription initiation process that results in RNA synthesis by RNA polymerase I." [GOC:mah]
synonym: "transcription initiation from Pol I promoter" EXACT []
xref: Reactome:448633 "RNA Polymerase I Transcription Initiation"
xref: Reactome:448634 "RNA Polymerase I Promoter Clearance"
xref: Reactome:449183 "RNA Polymerase I Promoter Escape"
xref: Reactome:449253 "RNA Polymerase I Promoter Opening"
xref: Reactome:469761 "RNA Polymerase I Transcription Initiation"
xref: Reactome:469762 "RNA Polymerase I Promoter Clearance"
xref: Reactome:470301 "RNA Polymerase I Promoter Escape"
xref: Reactome:470372 "RNA Polymerase I Promoter Opening"
xref: Reactome:487641 "RNA Polymerase I Transcription Initiation"
xref: Reactome:487642 "RNA Polymerase I Promoter Clearance"
xref: Reactome:487980 "RNA Polymerase I Promoter Escape"
xref: Reactome:507601 "RNA Polymerase I Transcription Initiation"
xref: Reactome:507602 "RNA Polymerase I Promoter Clearance"
xref: Reactome:507948 "RNA Polymerase I Promoter Escape"
xref: Reactome:508010 "RNA Polymerase I Promoter Opening"
xref: Reactome:517632 "RNA Polymerase I Transcription Initiation"
xref: Reactome:517633 "RNA Polymerase I Promoter Clearance"
xref: Reactome:526432 "RNA Polymerase I Transcription Initiation"
xref: Reactome:526433 "RNA Polymerase I Promoter Clearance"
xref: Reactome:526656 "RNA Polymerase I Promoter Escape"
xref: Reactome:531275 "RNA Polymerase I Transcription Initiation"
xref: Reactome:531276 "RNA Polymerase I Promoter Clearance"
xref: Reactome:536619 "RNA Polymerase I Transcription Initiation"
xref: Reactome:536620 "RNA Polymerase I Promoter Clearance"
xref: Reactome:536825 "RNA Polymerase I Promoter Escape"
xref: Reactome:542344 "RNA Polymerase I Transcription Initiation"
xref: Reactome:542345 "RNA Polymerase I Promoter Clearance"
xref: Reactome:542577 "RNA Polymerase I Promoter Escape"
xref: Reactome:547685 "RNA Polymerase I Transcription Initiation"
xref: Reactome:547686 "RNA Polymerase I Promoter Clearance"
xref: Reactome:547900 "RNA Polymerase I Promoter Escape"
xref: Reactome:552270 "RNA Polymerase I Transcription Initiation"
xref: Reactome:552271 "RNA Polymerase I Promoter Clearance"
xref: Reactome:552476 "RNA Polymerase I Promoter Escape"
xref: Reactome:557894 "RNA Polymerase I Transcription Initiation"
xref: Reactome:557895 "RNA Polymerase I Promoter Clearance"
xref: Reactome:568492 "RNA Polymerase I Transcription Initiation"
xref: Reactome:568493 "RNA Polymerase I Promoter Clearance"
xref: Reactome:568731 "RNA Polymerase I Promoter Escape"
xref: Reactome:568759 "RNA Polymerase I Promoter Opening"
xref: Reactome:581703 "RNA Polymerase I Transcription Initiation"
xref: Reactome:581704 "RNA Polymerase I Promoter Clearance"
xref: Reactome:581934 "RNA Polymerase I Promoter Escape"
xref: Reactome:581963 "RNA Polymerase I Promoter Opening"
xref: Reactome:592609 "RNA Polymerase I Transcription Initiation"
xref: Reactome:592610 "RNA Polymerase I Promoter Clearance"
xref: Reactome:592831 "RNA Polymerase I Promoter Escape"
xref: Reactome:595416 "RNA Polymerase I Transcription Initiation"
xref: Reactome:595417 "RNA Polymerase I Promoter Clearance"
xref: Reactome:73728 "RNA Polymerase I Promoter Opening"
xref: Reactome:73762 "RNA Polymerase I Transcription Initiation"
xref: Reactome:73772 "RNA Polymerase I Promoter Escape"
xref: Reactome:73854 "RNA Polymerase I Promoter Clearance"
is_a: GO:0006352 ! transcription initiation
relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter

[Term]
id: GO:0006362
name: RNA elongation from RNA polymerase I promoter
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation at an RNA polymerase I-specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I." [GOC:mah]
synonym: "RNA elongation from Pol I promoter" EXACT []
xref: Reactome:449071 "RNA Polymerase I Chain Elongation"
xref: Reactome:470184 "RNA Polymerase I Chain Elongation"
xref: Reactome:487869 "RNA Polymerase I Chain Elongation"
xref: Reactome:507841 "RNA Polymerase I Chain Elongation"
xref: Reactome:526585 "RNA Polymerase I Chain Elongation"
xref: Reactome:536756 "RNA Polymerase I Chain Elongation"
xref: Reactome:542511 "RNA Polymerase I Chain Elongation"
xref: Reactome:547834 "RNA Polymerase I Chain Elongation"
xref: Reactome:552406 "RNA Polymerase I Chain Elongation"
xref: Reactome:568665 "RNA Polymerase I Chain Elongation"
xref: Reactome:581868 "RNA Polymerase I Chain Elongation"
xref: Reactome:592772 "RNA Polymerase I Chain Elongation"
xref: Reactome:73777 "RNA Polymerase I Chain Elongation"
is_a: GO:0006354 ! RNA elongation
relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter

[Term]
id: GO:0006363
name: termination of RNA polymerase I transcription
namespace: biological_process
alt_id: GO:0019223
def: "The process by which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed; typically occurs within U-rich regions." [GOC:mah, PMID:12944462]
synonym: "RNA polymerase I transcription termination" EXACT []
synonym: "transcription termination from Pol I promoter" EXACT []
synonym: "transcription termination from RNA polymerase I promoter" EXACT []
xref: Reactome:449052 "RNA Polymerase I Transcription Termination"
xref: Reactome:470166 "RNA Polymerase I Transcription Termination"
xref: Reactome:488065 "RNA Polymerase I Transcription Termination"
xref: Reactome:507827 "RNA Polymerase I Transcription Termination"
xref: Reactome:568760 "RNA Polymerase I Transcription Termination"
xref: Reactome:73863 "RNA Polymerase I Transcription Termination"
is_a: GO:0006353 ! transcription termination
relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter

[Term]
id: GO:0006364
name: rRNA processing
namespace: biological_process
alt_id: GO:0006365
def: "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators]
subset: gosubset_prok
synonym: "35S primary transcript processing" NARROW []
is_a: GO:0016072 ! rRNA metabolic process
is_a: GO:0034470 ! ncRNA processing
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0006366
name: transcription from RNA polymerase II promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, ISBN:0321000382]
synonym: "transcription from Pol II promoter" EXACT []
xref: Reactome:448705 "RNA Polymerase II Transcription"
xref: Reactome:469827 "RNA Polymerase II Transcription"
xref: Reactome:487520 "RNA Polymerase II Transcription"
xref: Reactome:507481 "RNA Polymerase II Transcription"
xref: Reactome:517465 "RNA Polymerase II Transcription"
xref: Reactome:526338 "RNA Polymerase II Transcription"
xref: Reactome:531171 "RNA Polymerase II Transcription"
xref: Reactome:536546 "RNA Polymerase II Transcription"
xref: Reactome:542267 "RNA Polymerase II Transcription"
xref: Reactome:547613 "RNA Polymerase II Transcription"
xref: Reactome:552217 "RNA Polymerase II Transcription"
xref: Reactome:557807 "RNA Polymerase II Transcription"
xref: Reactome:568424 "RNA Polymerase II Transcription"
xref: Reactome:581626 "RNA Polymerase II Transcription"
xref: Reactome:592523 "RNA Polymerase II Transcription"
xref: Reactome:595358 "RNA Polymerase II Transcription"
xref: Reactome:73857 "RNA Polymerase II Transcription"
is_a: GO:0006351 ! transcription, DNA-dependent

[Term]
id: GO:0006367
name: transcription initiation from RNA polymerase II promoter
namespace: biological_process
def: "A transcription initiation process that results in RNA synthesis by RNA polymerase II." [GOC:mah]
synonym: "transcription initiation from Pol II promoter" EXACT []
xref: Reactome:167161 "HIV-1 Transcription Initiation"
xref: Reactome:448928 "RNA Polymerase II Transcription Pre-Initiation"
xref: Reactome:449205 "RNA Polymerase II Transcription Initiation"
xref: Reactome:470045 "RNA Polymerase II Transcription Pre-Initiation"
xref: Reactome:470326 "RNA Polymerase II Transcription Initiation"
xref: Reactome:487746 "RNA Polymerase II Transcription Pre-Initiation"
xref: Reactome:488003 "RNA Polymerase II Transcription Initiation"
xref: Reactome:507701 "RNA Polymerase II Transcription Pre-Initiation"
xref: Reactome:507966 "RNA Polymerase II Transcription Initiation"
xref: Reactome:517635 "RNA Polymerase II Transcription Pre-Initiation"
xref: Reactome:517838 "RNA Polymerase II Transcription Initiation"
xref: Reactome:526481 "RNA Polymerase II Transcription Pre-Initiation"
xref: Reactome:526674 "RNA Polymerase II Transcription Initiation"
xref: Reactome:536656 "RNA Polymerase II Transcription Pre-Initiation"
xref: Reactome:536838 "RNA Polymerase II Transcription Initiation"
xref: Reactome:542386 "RNA Polymerase II Transcription Pre-Initiation"
xref: Reactome:542592 "RNA Polymerase II Transcription Initiation"
xref: Reactome:547731 "RNA Polymerase II Transcription Pre-Initiation"
xref: Reactome:547911 "RNA Polymerase II Transcription Initiation"
xref: Reactome:552304 "RNA Polymerase II Transcription Pre-Initiation"
xref: Reactome:552492 "RNA Polymerase II Transcription Initiation"
xref: Reactome:568539 "RNA Polymerase II Transcription Pre-Initiation"
xref: Reactome:568741 "RNA Polymerase II Transcription Initiation"
xref: Reactome:581750 "RNA Polymerase II Transcription Pre-Initiation"
xref: Reactome:581944 "RNA Polymerase II Transcription Initiation"
xref: Reactome:592663 "RNA Polymerase II Transcription Pre-Initiation"
xref: Reactome:592841 "RNA Polymerase II Transcription Initiation"
xref: Reactome:73779 "RNA Polymerase II Transcription Pre-Initiation"
xref: Reactome:75953 "RNA Polymerase II Transcription Initiation"
is_a: GO:0006352 ! transcription initiation
relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter

[Term]
id: GO:0006368
name: RNA elongation from RNA polymerase II promoter
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation at an RNA polymerase II-specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah]
synonym: "RNA elongation from Pol II promoter" EXACT []
xref: Reactome:112382 "Formation of RNA Pol II elongation complex"
xref: Reactome:113418 "Formation of the Early Elongation Complex"
xref: Reactome:167169 "HIV-1 Transcription Elongation"
xref: Reactome:448736 "RNA Polymerase II Promoter Escape"
xref: Reactome:448740 "RNA Polymerase II Transcription Elongation"
xref: Reactome:449065 "Formation of the Early Elongation Complex"
xref: Reactome:449148 "Formation of RNA Pol II elongation complex"
xref: Reactome:469858 "RNA Polymerase II Promoter Escape"
xref: Reactome:469862 "RNA Polymerase II Transcription Elongation"
xref: Reactome:470178 "Formation of the Early Elongation Complex"
xref: Reactome:470262 "Formation of RNA Pol II elongation complex"
xref: Reactome:487555 "RNA Polymerase II Promoter Escape"
xref: Reactome:487559 "RNA Polymerase II Transcription Elongation"
xref: Reactome:487863 "Formation of the Early Elongation Complex"
xref: Reactome:487941 "Formation of RNA Pol II elongation complex"
xref: Reactome:507511 "RNA Polymerase II Promoter Escape"
xref: Reactome:507515 "RNA Polymerase II Transcription Elongation"
xref: Reactome:507835 "Formation of the Early Elongation Complex"
xref: Reactome:508032 "Formation of RNA Pol II elongation complex"
xref: Reactome:517495 "RNA Polymerase II Promoter Escape"
xref: Reactome:517499 "RNA Polymerase II Transcription Elongation"
xref: Reactome:517770 "Formation of the Early Elongation Complex"
xref: Reactome:517796 "Formation of RNA Pol II elongation complex"
xref: Reactome:526364 "RNA Polymerase II Promoter Escape"
xref: Reactome:526368 "RNA Polymerase II Transcription Elongation"
xref: Reactome:526578 "Formation of the Early Elongation Complex"
xref: Reactome:526631 "Formation of RNA Pol II elongation complex"
xref: Reactome:536560 "RNA Polymerase II Promoter Escape"
xref: Reactome:536799 "Formation of the Early Elongation Complex"
xref: Reactome:536800 "RNA Polymerase II Transcription Elongation"
xref: Reactome:542286 "RNA Polymerase II Promoter Escape"
xref: Reactome:542558 "Formation of the Early Elongation Complex"
xref: Reactome:542559 "RNA Polymerase II Transcription Elongation"
xref: Reactome:547627 "RNA Polymerase II Promoter Escape"
xref: Reactome:547882 "Formation of the Early Elongation Complex"
xref: Reactome:547883 "RNA Polymerase II Transcription Elongation"
xref: Reactome:552219 "RNA Polymerase II Promoter Escape"
xref: Reactome:552457 "Formation of the Early Elongation Complex"
xref: Reactome:552458 "RNA Polymerase II Transcription Elongation"
xref: Reactome:557824 "RNA Polymerase II Promoter Escape"
xref: Reactome:558066 "Formation of the Early Elongation Complex"
xref: Reactome:558067 "RNA Polymerase II Transcription Elongation"
xref: Reactome:568426 "RNA Polymerase II Promoter Escape"
xref: Reactome:568658 "Formation of the Early Elongation Complex"
xref: Reactome:568659 "RNA Polymerase II Transcription Elongation"
xref: Reactome:581628 "RNA Polymerase II Promoter Escape"
xref: Reactome:581861 "Formation of the Early Elongation Complex"
xref: Reactome:581862 "RNA Polymerase II Transcription Elongation"
xref: Reactome:592537 "RNA Polymerase II Promoter Escape"
xref: Reactome:592541 "RNA Polymerase II Transcription Elongation"
xref: Reactome:592812 "Formation of the Early Elongation Complex"
xref: Reactome:595360 "RNA Polymerase II Promoter Escape"
xref: Reactome:73776 "RNA Polymerase II Promoter Escape"
xref: Reactome:75955 "RNA Polymerase II Transcription Elongation"
is_a: GO:0006354 ! RNA elongation
relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter

[Term]
id: GO:0006369
name: termination of RNA polymerase II transcription
namespace: biological_process
alt_id: GO:0019224
def: "The process by which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed." [GOC:mah]
synonym: "RNA polymerase II transcription termination" EXACT []
synonym: "transcription termination from Pol II promoter" EXACT []
synonym: "transcription termination from RNA polymerase II promoter" EXACT []
xref: Reactome:109688 "Cleavage of Growing Transcript in the Termination Region"
xref: Reactome:167168 "HIV-1 Transcription Termination"
xref: Reactome:448972 "Cleavage of Growing Transcript in the Termination Region"
xref: Reactome:448973 "RNA Polymerase II Transcription Termination"
xref: Reactome:487782 "Cleavage of Growing Transcript in the Termination Region"
xref: Reactome:487783 "RNA Polymerase II Transcription Termination"
xref: Reactome:507746 "Cleavage of Growing Transcript in the Termination Region"
xref: Reactome:507747 "RNA Polymerase II Transcription Termination"
xref: Reactome:517677 "Cleavage of Growing Transcript in the Termination Region"
xref: Reactome:517678 "RNA Polymerase II Transcription Termination"
xref: Reactome:526510 "Cleavage of Growing Transcript in the Termination Region"
xref: Reactome:526511 "RNA Polymerase II Transcription Termination"
xref: Reactome:568581 "Cleavage of Growing Transcript in the Termination Region"
xref: Reactome:568582 "RNA Polymerase II Transcription Termination"
xref: Reactome:581787 "Cleavage of Growing Transcript in the Termination Region"
xref: Reactome:581788 "RNA Polymerase II Transcription Termination"
xref: Reactome:592702 "Cleavage of Growing Transcript in the Termination Region"
xref: Reactome:592703 "RNA Polymerase II Transcription Termination"
xref: Reactome:73856 "RNA Polymerase II Transcription Termination"
is_a: GO:0006353 ! transcription termination
relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter

[Term]
id: GO:0006370
name: mRNA capping
namespace: biological_process
def: "Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685]
synonym: "5' end capping" BROAD []
synonym: "5' mRNA capping" EXACT []
synonym: "5'-end mRNA processing" EXACT []
synonym: "5'-end processing" BROAD []
xref: Reactome:448948 "mRNA Capping"
xref: Reactome:470067 "mRNA Capping"
xref: Reactome:487760 "mRNA Capping"
xref: Reactome:507724 "mRNA Capping"
xref: Reactome:517656 "mRNA Capping"
xref: Reactome:526489 "mRNA Capping"
xref: Reactome:531303 "mRNA Capping"
xref: Reactome:536678 "mRNA Capping"
xref: Reactome:542411 "mRNA Capping"
xref: Reactome:547760 "mRNA Capping"
xref: Reactome:552330 "mRNA Capping"
xref: Reactome:557936 "mRNA Capping"
xref: Reactome:568563 "mRNA Capping"
xref: Reactome:581767 "mRNA Capping"
xref: Reactome:592684 "mRNA Capping"
xref: Reactome:595442 "mRNA Capping"
xref: Reactome:72086 "mRNA Capping"
is_a: GO:0006397 ! mRNA processing
is_a: GO:0009452 ! RNA capping

[Term]
id: GO:0006371
name: mRNA splicing
namespace: biological_process
def: "OBSOLETE. The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents several different processes.
is_obsolete: true
consider: GO:0000372
consider: GO:0000373
consider: GO:0000374
consider: GO:0000394
consider: GO:0000398

[Term]
id: GO:0006372
name: lariat formation, 5'-splice site cleavage
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it represents a molecular function.
is_obsolete: true
consider: GO:0000350
consider: GO:0000386

[Term]
id: GO:0006373
name: 3'-splice site cleavage, exon ligation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it represents a molecular function.
is_obsolete: true
consider: GO:0000386
consider: GO:0000388
consider: GO:0000393

[Term]
id: GO:0006376
name: mRNA splice site selection
namespace: biological_process
def: "Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897]
synonym: "spliceosomal commitment complex biosynthesis" NARROW []
synonym: "spliceosomal commitment complex formation" NARROW []
synonym: "spliceosomal E complex biosynthesis" NARROW []
synonym: "spliceosomal E complex formation" NARROW []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000245 ! spliceosome assembly

[Term]
id: GO:0006377
name: MATa1 (A1) pre-mRNA splicing
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it does not represent a process unique to splicing of the MATa1 (A1) pre-mRNA, but a recycling defect exacerbated by the presence of two introns within the same gene.
is_obsolete: true
consider: GO:0000244

[Term]
id: GO:0006378
name: mRNA polyadenylation
namespace: biological_process
def: "The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cleavage and polyadenylylation specificity factor activity" NARROW []
synonym: "mRNA polyadenylylation" EXACT []
is_a: GO:0031124 ! mRNA 3'-end processing
is_a: GO:0043631 ! RNA polyadenylation

[Term]
id: GO:0006379
name: mRNA cleavage
namespace: biological_process
def: "Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah]
subset: gosubset_prok
synonym: "cleavage and polyadenylylation specificity factor activity" RELATED []
synonym: "cleavage stimulation factor activity" RELATED []
synonym: "pre-mRNA cleavage factor activity" RELATED []
is_a: GO:0006397 ! mRNA processing

[Term]
id: GO:0006380
name: poly-A binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
is_obsolete: true
consider: GO:0008143

[Term]
id: GO:0006382
name: adenosine to inosine editing
namespace: biological_process
def: "The conversion of an adenosine residue to inosine in an RNA molecule by deamination." [PMID:11092837]
subset: gosubset_prok
xref: Reactome:448904 "mRNA Editing: A to I Conversion"
xref: Reactome:470021 "mRNA Editing: A to I Conversion"
xref: Reactome:487722 "mRNA Editing: A to I Conversion"
xref: Reactome:507673 "mRNA Editing: A to I Conversion"
xref: Reactome:517614 "mRNA Editing: A to I Conversion"
xref: Reactome:526464 "mRNA Editing: A to I Conversion"
xref: Reactome:531268 "mRNA Editing: A to I Conversion"
xref: Reactome:536648 "mRNA Editing: A to I Conversion"
xref: Reactome:542377 "mRNA Editing: A to I Conversion"
xref: Reactome:547722 "mRNA Editing: A to I Conversion"
xref: Reactome:557918 "mRNA Editing: A to I Conversion"
xref: Reactome:568530 "mRNA Editing: A to I Conversion"
xref: Reactome:581742 "mRNA Editing: A to I Conversion"
xref: Reactome:585868 "mRNA Editing: A to I Conversion"
xref: Reactome:75064 "mRNA Editing: A to I Conversion"
is_a: GO:0016553 ! base conversion or substitution editing

[Term]
id: GO:0006383
name: transcription from RNA polymerase III promoter
namespace: biological_process
def: "The synthesis of RNA from a DNA template by RNA polymerase III (Pol III), originating at a Pol III-specific promoter." [GOC:jl]
subset: gosubset_prok
synonym: "transcription from Pol III promoter" EXACT []
xref: Reactome:112054 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters"
xref: Reactome:112055 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters"
xref: Reactome:112149 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters"
xref: Reactome:112153 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters"
xref: Reactome:112155 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters"
xref: Reactome:112156 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters"
xref: Reactome:113442 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:113446 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:113451 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:113705 "RNA Polymerase III Productive Transcription"
xref: Reactome:440661 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:446506 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:446557 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters"
xref: Reactome:446559 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters"
xref: Reactome:446561 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters"
xref: Reactome:446562 "RNA Polymerase III Productive Transcription"
xref: Reactome:446563 "RNA Polymerase III Promoter Opening at Type 1 Promoters"
xref: Reactome:446566 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:446567 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters"
xref: Reactome:446568 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters"
xref: Reactome:446569 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters"
xref: Reactome:448927 "RNA Polymerase III Transcription"
xref: Reactome:462447 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:467829 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:467887 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters"
xref: Reactome:467889 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters"
xref: Reactome:467891 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters"
xref: Reactome:467892 "RNA Polymerase III Productive Transcription"
xref: Reactome:467893 "RNA Polymerase III Promoter Opening at Type 1 Promoters"
xref: Reactome:467896 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:467897 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters"
xref: Reactome:467898 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters"
xref: Reactome:467899 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters"
xref: Reactome:470044 "RNA Polymerase III Transcription"
xref: Reactome:481191 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:485728 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:485778 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters"
xref: Reactome:485780 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters"
xref: Reactome:485782 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters"
xref: Reactome:485783 "RNA Polymerase III Productive Transcription"
xref: Reactome:485787 "RNA Polymerase III Promoter Opening at Type 1 Promoters"
xref: Reactome:485793 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:485794 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters"
xref: Reactome:485795 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters"
xref: Reactome:485796 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters"
xref: Reactome:487744 "RNA Polymerase III Transcription"
xref: Reactome:501244 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:505619 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:505661 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters"
xref: Reactome:505663 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters"
xref: Reactome:505665 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters"
xref: Reactome:505666 "RNA Polymerase III Productive Transcription"
xref: Reactome:505667 "RNA Polymerase III Promoter Opening at Type 1 Promoters"
xref: Reactome:505670 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:505671 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters"
xref: Reactome:505672 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters"
xref: Reactome:505673 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters"
xref: Reactome:507699 "RNA Polymerase III Transcription"
xref: Reactome:514414 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:516415 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:516446 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters"
xref: Reactome:516448 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters"
xref: Reactome:516449 "RNA Polymerase III Productive Transcription"
xref: Reactome:516450 "RNA Polymerase III Promoter Opening at Type 1 Promoters"
xref: Reactome:516452 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:516453 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters"
xref: Reactome:516454 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters"
xref: Reactome:517638 "RNA Polymerase III Transcription"
xref: Reactome:523446 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:525418 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:525460 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters"
xref: Reactome:525461 "RNA Polymerase III Productive Transcription"
xref: Reactome:525466 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:525467 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters"
xref: Reactome:526634 "RNA Polymerase III Transcription"
xref: Reactome:529736 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:530641 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:530661 "RNA Polymerase III Productive Transcription"
xref: Reactome:530662 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:531280 "RNA Polymerase III Transcription"
xref: Reactome:536807 "RNA Polymerase III Transcription"
xref: Reactome:540600 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:541665 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:541686 "RNA Polymerase III Productive Transcription"
xref: Reactome:541687 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:542389 "RNA Polymerase III Transcription"
xref: Reactome:546229 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:547103 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:547137 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters"
xref: Reactome:547139 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters"
xref: Reactome:547140 "RNA Polymerase III Productive Transcription"
xref: Reactome:547144 "RNA Polymerase III Promoter Opening at Type 1 Promoters"
xref: Reactome:547149 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:547150 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters"
xref: Reactome:547151 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters"
xref: Reactome:547734 "RNA Polymerase III Transcription"
xref: Reactome:550959 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:551701 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:551722 "RNA Polymerase III Productive Transcription"
xref: Reactome:551723 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:552464 "RNA Polymerase III Transcription"
xref: Reactome:556167 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:557212 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:557234 "RNA Polymerase III Productive Transcription"
xref: Reactome:557235 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:558071 "RNA Polymerase III Transcription"
xref: Reactome:565792 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:567415 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:567460 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters"
xref: Reactome:567462 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters"
xref: Reactome:567463 "RNA Polymerase III Productive Transcription"
xref: Reactome:567467 "RNA Polymerase III Promoter Opening at Type 1 Promoters"
xref: Reactome:567472 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:567473 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters"
xref: Reactome:567474 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters"
xref: Reactome:568542 "RNA Polymerase III Transcription"
xref: Reactome:578494 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:580511 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:580553 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters"
xref: Reactome:580555 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters"
xref: Reactome:580556 "RNA Polymerase III Productive Transcription"
xref: Reactome:580560 "RNA Polymerase III Promoter Opening at Type 1 Promoters"
xref: Reactome:580565 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:580566 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters"
xref: Reactome:580567 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters"
xref: Reactome:581753 "RNA Polymerase III Transcription"
xref: Reactome:584724 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:585482 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:585500 "RNA Polymerase III Productive Transcription"
xref: Reactome:585501 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:585957 "RNA Polymerase III Transcription"
xref: Reactome:590523 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:591924 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:591941 "RNA Polymerase III Productive Transcription"
xref: Reactome:591942 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:592666 "RNA Polymerase III Transcription"
xref: Reactome:594565 "Initiation of RNA Polymerase III Productive Transcription"
xref: Reactome:594981 "Resumption of RNA Polymerase III Productive Transcription"
xref: Reactome:595002 "RNA Polymerase III Productive Transcription"
xref: Reactome:595003 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites"
xref: Reactome:595537 "RNA Polymerase III Transcription"
xref: Reactome:74158 "RNA Polymerase III Transcription"
xref: Reactome:76060 "RNA Polymerase III Promoter Opening at Type 1 Promoters"
is_a: GO:0006351 ! transcription, DNA-dependent

[Term]
id: GO:0006384
name: transcription initiation from RNA polymerase III promoter
namespace: biological_process
def: "A transcription initiation process that results in RNA synthesis by RNA polymerase III." [GOC:mah]
synonym: "transcription initiation from Pol III promoter" EXACT []
is_a: GO:0006352 ! transcription initiation
relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter

[Term]
id: GO:0006385
name: RNA elongation from RNA polymerase III promoter
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation at an RNA polymerase III-specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase III." [GOC:mah]
synonym: "RNA elongation from Pol III promoter" EXACT []
xref: Reactome:449155 "RNA Polymerase III Chain Elongation"
xref: Reactome:470269 "RNA Polymerase III Chain Elongation"
xref: Reactome:487949 "RNA Polymerase III Chain Elongation"
xref: Reactome:507920 "RNA Polymerase III Chain Elongation"
xref: Reactome:517800 "RNA Polymerase III Chain Elongation"
xref: Reactome:526633 "RNA Polymerase III Chain Elongation"
xref: Reactome:531434 "RNA Polymerase III Chain Elongation"
xref: Reactome:536806 "RNA Polymerase III Chain Elongation"
xref: Reactome:542566 "RNA Polymerase III Chain Elongation"
xref: Reactome:547886 "RNA Polymerase III Chain Elongation"
xref: Reactome:552463 "RNA Polymerase III Chain Elongation"
xref: Reactome:558070 "RNA Polymerase III Chain Elongation"
xref: Reactome:568720 "RNA Polymerase III Chain Elongation"
xref: Reactome:581923 "RNA Polymerase III Chain Elongation"
xref: Reactome:585956 "RNA Polymerase III Chain Elongation"
xref: Reactome:592814 "RNA Polymerase III Chain Elongation"
xref: Reactome:595536 "RNA Polymerase III Chain Elongation"
xref: Reactome:73780 "RNA Polymerase III Chain Elongation"
is_a: GO:0006354 ! RNA elongation
relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter

[Term]
id: GO:0006386
name: termination of RNA polymerase III transcription
namespace: biological_process
alt_id: GO:0019225
def: "The process by which transcription by RNA polymerase III is terminated; Pol III has an intrinsic ability to terminate transcription upon incorporation of 4 to 6 contiguous U residues." [GOC:mah, PMID:12944462]
synonym: "RNA polymerase III transcription termination" EXACT []
synonym: "transcription termination from Pol III promoter" EXACT []
synonym: "transcription termination from RNA polymerase III promoter" EXACT []
xref: Reactome:112466 "RNA Polymerase III Transcriptional Pause at Terminator Sequence"
xref: Reactome:112480 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:113454 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:446582 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:449279 "RNA Polymerase III Transcription Termination"
xref: Reactome:467915 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:470399 "RNA Polymerase III Transcription Termination"
xref: Reactome:485804 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:488077 "RNA Polymerase III Transcription Termination"
xref: Reactome:505688 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:508044 "RNA Polymerase III Transcription Termination"
xref: Reactome:516460 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:517896 "RNA Polymerase III Transcription Termination"
xref: Reactome:525473 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:526723 "RNA Polymerase III Transcription Termination"
xref: Reactome:530666 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:531495 "RNA Polymerase III Transcription Termination"
xref: Reactome:536885 "RNA Polymerase III Transcription Termination"
xref: Reactome:541691 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:542635 "RNA Polymerase III Transcription Termination"
xref: Reactome:547155 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:547951 "RNA Polymerase III Transcription Termination"
xref: Reactome:551727 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:552525 "RNA Polymerase III Transcription Termination"
xref: Reactome:557239 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:558148 "RNA Polymerase III Transcription Termination"
xref: Reactome:567478 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:568774 "RNA Polymerase III Transcription Termination"
xref: Reactome:580576 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:581977 "RNA Polymerase III Transcription Termination"
xref: Reactome:585505 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:586028 "RNA Polymerase III Transcription Termination"
xref: Reactome:591946 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:592885 "RNA Polymerase III Transcription Termination"
xref: Reactome:595005 "RNA Polymerase III Termination and release of transcribed mRNA"
xref: Reactome:595588 "RNA Polymerase III Transcription Termination"
xref: Reactome:73980 "RNA Polymerase III Transcription Termination"
is_a: GO:0006353 ! transcription termination
relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter

[Term]
id: GO:0006387
name: snRNA capping
namespace: biological_process
is_a: GO:0009452 ! RNA capping
is_a: GO:0016180 ! snRNA processing

[Term]
id: GO:0006388
name: tRNA splicing, via endonucleolytic cleavage and ligation
namespace: biological_process
def: "Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290]
comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis.
subset: gosubset_prok
synonym: "tRNA-Y splicing" NARROW []
is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation
is_a: GO:0008033 ! tRNA processing

[Term]
id: GO:0006389
name: tRNA-Y splicing
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it does not represent a process unique to splicing of the tyrosyl (Y) tRNA.
is_obsolete: true
consider: GO:0006388

[Term]
id: GO:0006390
name: transcription from mitochondrial promoter
namespace: biological_process
def: "The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl]
synonym: "mitochondrial transcription" EXACT []
xref: Reactome:448853 "Transcription from mitochondrial promoters"
xref: Reactome:469970 "Transcription from mitochondrial promoters"
xref: Reactome:487687 "Transcription from mitochondrial promoters"
xref: Reactome:507631 "Transcription from mitochondrial promoters"
xref: Reactome:517907 "Transcription from mitochondrial promoters"
xref: Reactome:526735 "Transcription from mitochondrial promoters"
xref: Reactome:75944 "Transcription from mitochondrial promoters"
is_a: GO:0006351 ! transcription, DNA-dependent
is_a: GO:0007005 ! mitochondrion organization

[Term]
id: GO:0006391
name: transcription initiation from mitochondrial promoter
namespace: biological_process
def: "A transcription initiation process that takes place at a promoter on the mitochondrial chromosome, and results in RNA synthesis by a mitochondrial RNA polymerase." [GOC:mah]
xref: Reactome:163282 "Mitochondrial transcription initiation"
xref: Reactome:448864 "Mitochondrial transcription initiation"
xref: Reactome:469981 "Mitochondrial transcription initiation"
xref: Reactome:487686 "Mitochondrial transcription initiation"
xref: Reactome:517906 "Mitochondrial transcription initiation"
xref: Reactome:526734 "Mitochondrial transcription initiation"
is_a: GO:0006352 ! transcription initiation
relationship: part_of GO:0006390 ! transcription from mitochondrial promoter

[Term]
id: GO:0006392
name: RNA elongation from mitochondrial promoter
namespace: biological_process
def: "The extension of an RNA molecule after transcription initiation at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase." [GOC:mah]
is_a: GO:0006354 ! RNA elongation
relationship: part_of GO:0006390 ! transcription from mitochondrial promoter

[Term]
id: GO:0006393
name: termination of mitochondrial transcription
namespace: biological_process
def: "The process by which the synthesis of an RNA molecule using a mitochondrial DNA template is completed." [GOC:mah]
synonym: "mitochondrial transcription termination" EXACT []
synonym: "RNA transcription termination from mitochondrial promoter" EXACT []
xref: Reactome:163316 "Mitochondrial transcription termination"
xref: Reactome:448852 "Mitochondrial transcription termination"
xref: Reactome:469969 "Mitochondrial transcription termination"
xref: Reactome:507630 "Mitochondrial transcription termination"
is_a: GO:0006353 ! transcription termination
relationship: part_of GO:0006390 ! transcription from mitochondrial promoter

[Term]
id: GO:0006396
name: RNA processing
namespace: biological_process
alt_id: GO:0006394
def: "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Post-transcriptional_modification
is_a: GO:0016070 ! RNA metabolic process
relationship: part_of GO:0010467 ! gene expression

[Term]
id: GO:0006397
name: mRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah]
subset: gosubset_prok
synonym: "mRNA maturation" RELATED []
is_a: GO:0006396 ! RNA processing
is_a: GO:0016071 ! mRNA metabolic process

[Term]
id: GO:0006398
name: histone mRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a histone mRNA molecule." [GOC:mah]
synonym: "histone mRNA 3' end processing" EXACT []
is_a: GO:0008334 ! histone mRNA metabolic process
is_a: GO:0031124 ! mRNA 3'-end processing

[Term]
id: GO:0006399
name: tRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pombe
subset: gosubset_prok
synonym: "tRNA metabolism" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0006400
name: tRNA modification
namespace: biological_process
alt_id: GO:0016549
def: "The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]
comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'.
subset: gosubset_prok
synonym: "tRNA editing" EXACT []
is_a: GO:0008033 ! tRNA processing
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0006401
name: RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "RNA breakdown" EXACT []
synonym: "RNA catabolism" EXACT []
synonym: "RNA degradation" EXACT []
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0044265 ! cellular macromolecule catabolic process

[Term]
id: GO:0006402
name: mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "mRNA breakdown" EXACT []
synonym: "mRNA catabolism" EXACT []
synonym: "mRNA decay" RELATED [GOC:ascb_2010, GOC:dph, GOC:tb]
synonym: "mRNA degradation" EXACT []
is_a: GO:0006401 ! RNA catabolic process
is_a: GO:0016071 ! mRNA metabolic process

[Term]
id: GO:0006403
name: RNA localization
namespace: biological_process
def: "A process by which RNA is transported to, or maintained in, a specific location." [GOC:ai]
subset: gosubset_prok
synonym: "establishment and maintenance of RNA localization" EXACT []
is_a: GO:0033036 ! macromolecule localization

[Term]
id: GO:0006404
name: RNA import into nucleus
namespace: biological_process
def: "The import of RNA from the cytoplasm to the nucleus." [GOC:ma]
synonym: "RNA import into cell nucleus" EXACT []
synonym: "RNA transport from cytoplasm to nucleus" EXACT []
synonym: "RNA-nucleus import" EXACT []
is_a: GO:0050658 ! RNA transport
is_a: GO:0051170 ! nuclear import

[Term]
id: GO:0006405
name: RNA export from nucleus
namespace: biological_process
def: "The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma]
synonym: "RNA export from cell nucleus" EXACT []
synonym: "RNA export out of nucleus" EXACT []
synonym: "RNA transport from nucleus to cytoplasm" EXACT []
synonym: "RNA-nucleus export" EXACT []
xref: Reactome:158441 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC"
xref: Reactome:158447 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC"
xref: Reactome:158481 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC"
xref: Reactome:159101 "Recruitment of TAP to the EJC"
xref: Reactome:446139 "Recruitment of TAP to the EJC"
xref: Reactome:446433 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC"
xref: Reactome:447894 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC"
xref: Reactome:447896 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC"
xref: Reactome:467463 "Recruitment of TAP to the EJC"
xref: Reactome:467770 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC"
xref: Reactome:469096 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC"
xref: Reactome:469098 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC"
xref: Reactome:505236 "Recruitment of TAP to the EJC"
xref: Reactome:505541 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC"
xref: Reactome:506705 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC"
xref: Reactome:506708 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC"
xref: Reactome:516160 "Recruitment of TAP to the EJC"
xref: Reactome:516382 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC"
xref: Reactome:517005 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC"
xref: Reactome:517007 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC"
xref: Reactome:525156 "Recruitment of TAP to the EJC"
is_a: GO:0050658 ! RNA transport
is_a: GO:0051168 ! nuclear export

[Term]
id: GO:0006406
name: mRNA export from nucleus
namespace: biological_process
def: "The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma]
synonym: "mRNA export from cell nucleus" EXACT []
synonym: "mRNA export out of nucleus" EXACT []
synonym: "mRNA transport from nucleus to cytoplasm" EXACT []
synonym: "mRNA-nucleus export" EXACT []
xref: Reactome:111439 "Docking of Mature Histone mRNA complex:TAP at the NPC"
xref: Reactome:158484 "Release of the SLBP independent Histone mRNA from the NPC"
xref: Reactome:159046 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC"
xref: Reactome:159050 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex"
xref: Reactome:159234 "Transport of Mature mRNAs Derived from Intronless Transcripts"
xref: Reactome:159236 "Transport of Mature mRNA derived from an Intron-Containing Transcript"
xref: Reactome:437263 "Docking of Mature Histone mRNA complex:TAP at the NPC"
xref: Reactome:437269 "Docking of Mature Replication Dependent Histone mRNA with the NPC"
xref: Reactome:437273 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC"
xref: Reactome:446288 "Release from the NPC and Disassembly of the mRNP"
xref: Reactome:446438 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex"
xref: Reactome:446442 "Release of the SLBP independent Histone mRNA from the NPC"
xref: Reactome:447892 "Transport of the export-competent complex through the NPC"
xref: Reactome:447898 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC"
xref: Reactome:449056 "Transport of Mature mRNAs Derived from Intronless Transcripts"
xref: Reactome:449057 "Transport of Mature Transcript to Cytoplasm"
xref: Reactome:449272 "Transport of Mature mRNA derived from an Intron-Containing Transcript"
xref: Reactome:459387 "Docking of Mature Histone mRNA complex:TAP at the NPC"
xref: Reactome:459391 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC"
xref: Reactome:467591 "Release from the NPC and Disassembly of the mRNP"
xref: Reactome:467774 "Release of the SLBP independent Histone mRNA from the NPC"
xref: Reactome:469094 "Transport of the export-competent complex through the NPC"
xref: Reactome:470170 "Transport of Mature mRNAs Derived from Intronless Transcripts"
xref: Reactome:470171 "Transport of Mature Transcript to Cytoplasm"
xref: Reactome:470392 "Transport of Mature mRNA derived from an Intron-Containing Transcript"
xref: Reactome:486905 "Transport of the export-competent complex through the NPC"
xref: Reactome:488104 "Transport of Mature mRNA derived from an Intron-Containing Transcript"
xref: Reactome:488105 "Transport of Mature Transcript to Cytoplasm"
xref: Reactome:505354 "Release from the NPC and Disassembly of the mRNP"
xref: Reactome:505547 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex"
xref: Reactome:505551 "Release of the SLBP independent Histone mRNA from the NPC"
xref: Reactome:506702 "Transport of the export-competent complex through the NPC"
xref: Reactome:506712 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC"
xref: Reactome:508033 "Transport of Mature mRNA derived from an Intron-Containing Transcript"
xref: Reactome:508034 "Transport of Mature Transcript to Cytoplasm"
xref: Reactome:508038 "Transport of Mature mRNAs Derived from Intronless Transcripts"
xref: Reactome:513175 "Docking of Mature Histone mRNA complex:TAP at the NPC"
xref: Reactome:513181 "Docking of Mature Replication Dependent Histone mRNA with the NPC"
xref: Reactome:513185 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC"
xref: Reactome:516263 "Release from the NPC and Disassembly of the mRNP"
xref: Reactome:516387 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex"
xref: Reactome:516391 "Release of the SLBP independent Histone mRNA from the NPC"
xref: Reactome:517003 "Transport of the export-competent complex through the NPC"
xref: Reactome:517009 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC"
xref: Reactome:517737 "Transport of Mature mRNAs Derived from Intronless Transcripts"
xref: Reactome:517738 "Transport of Mature Transcript to Cytoplasm"
xref: Reactome:517890 "Transport of Mature mRNA derived from an Intron-Containing Transcript"
xref: Reactome:526713 "Transport of Mature mRNA derived from an Intron-Containing Transcript"
xref: Reactome:526714 "Transport of Mature Transcript to Cytoplasm"
xref: Reactome:72202 "Transport of Mature Transcript to Cytoplasm"
xref: Reactome:75096 "Docking of the TAP:EJC Complex with the NPC"
xref: Reactome:75097 "Transport of the export-competent complex through the NPC"
xref: Reactome:75098 "Release from the NPC and Disassembly of the mRNP"
xref: Reactome:77587 "Docking of Mature Replication Dependent Histone mRNA with the NPC"
xref: Reactome:77594 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC"
is_a: GO:0006405 ! RNA export from nucleus
is_a: GO:0051028 ! mRNA transport

[Term]
id: GO:0006407
name: rRNA export from nucleus
namespace: biological_process
def: "The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins." [GOC:ma, GOC:mah]
synonym: "rRNA export from cell nucleus" EXACT []
synonym: "rRNA export out of nucleus" EXACT []
synonym: "rRNA transport from nucleus to cytoplasm" EXACT []
synonym: "rRNA-nucleus export" EXACT []
is_a: GO:0006405 ! RNA export from nucleus
is_a: GO:0051029 ! rRNA transport
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0006408
name: snRNA export from nucleus
namespace: biological_process
def: "The directed movement of snRNA from the nucleus to the cytoplasm." [GOC:ma]
synonym: "snRNA export from cell nucleus" EXACT []
synonym: "snRNA export out of nucleus" EXACT []
synonym: "snRNA transport from nucleus to cytoplasm" EXACT []
synonym: "snRNA-nucleus export" EXACT []
is_a: GO:0006405 ! RNA export from nucleus
is_a: GO:0051030 ! snRNA transport

[Term]
id: GO:0006409
name: tRNA export from nucleus
namespace: biological_process
def: "The directed movement of tRNA from the nucleus to the cytoplasm." [GOC:ma]
synonym: "tRNA export from cell nucleus" EXACT []
synonym: "tRNA export out of nucleus" EXACT []
synonym: "tRNA transport from nucleus to cytoplasm" EXACT []
synonym: "tRNA-nucleus export" EXACT []
is_a: GO:0006405 ! RNA export from nucleus
is_a: GO:0051031 ! tRNA transport

[Term]
id: GO:0006410
name: transcription, RNA-dependent
namespace: biological_process
def: "The cellular synthesis of DNA on a template of RNA." [GOC:jl]
subset: gosubset_prok
synonym: "reverse transcription" EXACT []
xref: Wikipedia:Reverse_transcription
is_a: GO:0006350 ! transcription

[Term]
id: GO:0006412
name: translation
namespace: biological_process
alt_id: GO:0006416
alt_id: GO:0006453
alt_id: GO:0043037
def: "The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "protein anabolism" EXACT []
synonym: "protein biosynthesis" EXACT []
synonym: "protein formation" EXACT []
synonym: "protein synthesis" EXACT []
synonym: "protein translation" EXACT []
xref: Reactome:448800 "Translation"
xref: Reactome:469916 "Translation"
xref: Reactome:487622 "Translation"
xref: Reactome:507577 "Translation"
xref: Reactome:517550 "Translation"
xref: Reactome:526417 "Translation"
xref: Reactome:531240 "Translation"
xref: Reactome:536611 "Translation"
xref: Reactome:542335 "Translation"
xref: Reactome:547676 "Translation"
xref: Reactome:552260 "Translation"
xref: Reactome:557879 "Translation"
xref: Reactome:568477 "Translation"
xref: Reactome:581688 "Translation"
xref: Reactome:585834 "Translation"
xref: Reactome:592595 "Translation"
xref: Reactome:595406 "Translation"
xref: Reactome:597395 "Translation"
xref: Reactome:598177 "Translation"
xref: Reactome:599776 "Translation"
xref: Reactome:72766 "Translation"
xref: Wikipedia:Translation_(genetics)
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
is_a: GO:0044267 ! cellular protein metabolic process
relationship: part_of GO:0010467 ! gene expression

[Term]
id: GO:0006413
name: translational initiation
namespace: biological_process
alt_id: GO:0006440
alt_id: GO:0006454
def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X]
subset: gosubset_prok
synonym: "biopolymerisation" BROAD []
synonym: "biopolymerization" BROAD []
synonym: "protein synthesis initiation" BROAD []
synonym: "translation initiation" EXACT []
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0006414
name: translational elongation
namespace: biological_process
alt_id: GO:0006442
alt_id: GO:0006455
def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems]
subset: gosubset_prok
synonym: "protein synthesis elongation" BROAD []
synonym: "translation elongation" EXACT []
xref: Reactome:156842 "Eukaryotic Translation Elongation"
xref: Reactome:448799 "Eukaryotic Translation Elongation"
xref: Reactome:469915 "Eukaryotic Translation Elongation"
xref: Reactome:487621 "Eukaryotic Translation Elongation"
xref: Reactome:507576 "Eukaryotic Translation Elongation"
xref: Reactome:517549 "Eukaryotic Translation Elongation"
xref: Reactome:526416 "Eukaryotic Translation Elongation"
xref: Reactome:531239 "Eukaryotic Translation Elongation"
xref: Reactome:536610 "Eukaryotic Translation Elongation"
xref: Reactome:542334 "Eukaryotic Translation Elongation"
xref: Reactome:547675 "Eukaryotic Translation Elongation"
xref: Reactome:552259 "Eukaryotic Translation Elongation"
xref: Reactome:557878 "Eukaryotic Translation Elongation"
xref: Reactome:568476 "Eukaryotic Translation Elongation"
xref: Reactome:581687 "Eukaryotic Translation Elongation"
xref: Reactome:585833 "Eukaryotic Translation Elongation"
xref: Reactome:592594 "Eukaryotic Translation Elongation"
xref: Reactome:595405 "Eukaryotic Translation Elongation"
xref: Reactome:597399 "Eukaryotic Translation Elongation"
xref: Reactome:598179 "Eukaryotic Translation Elongation"
xref: Reactome:599775 "Eukaryotic Translation Elongation"
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0006415
name: translational termination
namespace: biological_process
alt_id: GO:0006443
alt_id: GO:0006456
def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X]
subset: gosubset_prok
synonym: "protein synthesis termination" BROAD []
synonym: "translation termination" EXACT []
synonym: "translational complex disassembly" EXACT []
xref: Reactome:141667 "GTP bound eRF3:eRF1 complex binds the peptidyl-tRNA:mRNA:Ribosome complex"
xref: Reactome:141671 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:141673 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:141687 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:141691 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:141696 "Eukaryotic Translation Termination"
xref: Reactome:141698 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:440258 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:440261 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:445575 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:449136 "Eukaryotic Translation Termination"
xref: Reactome:462009 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:462012 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:466915 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:470249 "Eukaryotic Translation Termination"
xref: Reactome:480779 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:480782 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:485039 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:487929 "Eukaryotic Translation Termination"
xref: Reactome:500822 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:500825 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:504825 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:507900 "Eukaryotic Translation Termination"
xref: Reactome:514179 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:514182 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:515979 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:517790 "Eukaryotic Translation Termination"
xref: Reactome:523207 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:523210 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:525025 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:526621 "Eukaryotic Translation Termination"
xref: Reactome:529589 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:529592 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:530370 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:531419 "Eukaryotic Translation Termination"
xref: Reactome:536791 "Eukaryotic Translation Termination"
xref: Reactome:540424 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:540427 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:541416 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:542548 "Eukaryotic Translation Termination"
xref: Reactome:546072 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:546075 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:546870 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:547875 "Eukaryotic Translation Termination"
xref: Reactome:550841 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:550844 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:551526 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:552449 "Eukaryotic Translation Termination"
xref: Reactome:556013 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:556016 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:556994 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:558060 "Eukaryotic Translation Termination"
xref: Reactome:565515 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:565518 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:567021 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:568706 "Eukaryotic Translation Termination"
xref: Reactome:578116 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:578119 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:579990 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:581909 "Eukaryotic Translation Termination"
xref: Reactome:584594 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:584597 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:585208 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:585947 "Eukaryotic Translation Termination"
xref: Reactome:590318 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:590321 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:591596 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:592804 "Eukaryotic Translation Termination"
xref: Reactome:594484 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex"
xref: Reactome:594487 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex"
xref: Reactome:594883 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex"
xref: Reactome:595531 "Eukaryotic Translation Termination"
xref: Reactome:72764 "Eukaryotic Translation Termination"
is_a: GO:0043624 ! cellular protein complex disassembly
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0006417
name: regulation of translation
namespace: biological_process
alt_id: GO:0006445
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
subset: gosubset_prok
synonym: "regulation of protein anabolism" EXACT []
synonym: "regulation of protein biosynthesis" EXACT []
synonym: "regulation of protein formation" EXACT []
synonym: "regulation of protein synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0010608 ! posttranscriptional regulation of gene expression
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0032268 ! regulation of cellular protein metabolic process
relationship: regulates GO:0006412 ! translation

[Term]
id: GO:0006418
name: tRNA aminoacylation for protein translation
namespace: biological_process
def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma]
subset: gosubset_prok
synonym: "tRNA charging" NARROW []
xref: MetaCyc:TRNA-CHARGING-PWY
xref: Reactome:379716 "Cytosolic tRNA aminoacylation"
xref: Reactome:379724 "tRNA Aminoacylation"
xref: Reactome:379726 "Mitochondrial tRNA aminoacylation"
xref: Reactome:448783 "Cytosolic tRNA aminoacylation"
xref: Reactome:448784 "tRNA Aminoacylation"
xref: Reactome:448785 "Mitochondrial tRNA aminoacylation"
xref: Reactome:469898 "Cytosolic tRNA aminoacylation"
xref: Reactome:469899 "tRNA Aminoacylation"
xref: Reactome:469900 "Mitochondrial tRNA aminoacylation"
xref: Reactome:487605 "Cytosolic tRNA aminoacylation"
xref: Reactome:487606 "tRNA Aminoacylation"
xref: Reactome:487607 "Mitochondrial tRNA aminoacylation"
xref: Reactome:507560 "Cytosolic tRNA aminoacylation"
xref: Reactome:507561 "tRNA Aminoacylation"
xref: Reactome:507562 "Mitochondrial tRNA aminoacylation"
xref: Reactome:517538 "Cytosolic tRNA aminoacylation"
xref: Reactome:517539 "tRNA Aminoacylation"
xref: Reactome:517540 "Mitochondrial tRNA aminoacylation"
xref: Reactome:526405 "Cytosolic tRNA aminoacylation"
xref: Reactome:526406 "tRNA Aminoacylation"
xref: Reactome:526407 "Mitochondrial tRNA aminoacylation"
xref: Reactome:531225 "Cytosolic tRNA aminoacylation"
xref: Reactome:531226 "tRNA Aminoacylation"
xref: Reactome:531228 "Mitochondrial tRNA aminoacylation"
xref: Reactome:536595 "Cytosolic tRNA aminoacylation"
xref: Reactome:536596 "tRNA Aminoacylation"
xref: Reactome:536597 "Mitochondrial tRNA aminoacylation"
xref: Reactome:542321 "Cytosolic tRNA aminoacylation"
xref: Reactome:542322 "tRNA Aminoacylation"
xref: Reactome:542323 "Mitochondrial tRNA aminoacylation"
xref: Reactome:547661 "Cytosolic tRNA aminoacylation"
xref: Reactome:547662 "tRNA Aminoacylation"
xref: Reactome:547663 "Mitochondrial tRNA aminoacylation"
xref: Reactome:552246 "Cytosolic tRNA aminoacylation"
xref: Reactome:552247 "tRNA Aminoacylation"
xref: Reactome:552248 "Mitochondrial tRNA aminoacylation"
xref: Reactome:557865 "Cytosolic tRNA aminoacylation"
xref: Reactome:557866 "tRNA Aminoacylation"
xref: Reactome:557867 "Mitochondrial tRNA aminoacylation"
xref: Reactome:568463 "Cytosolic tRNA aminoacylation"
xref: Reactome:568464 "tRNA Aminoacylation"
xref: Reactome:568465 "Mitochondrial tRNA aminoacylation"
xref: Reactome:581674 "Cytosolic tRNA aminoacylation"
xref: Reactome:581675 "tRNA Aminoacylation"
xref: Reactome:581676 "Mitochondrial tRNA aminoacylation"
xref: Reactome:585826 "Cytosolic tRNA aminoacylation"
xref: Reactome:585827 "tRNA Aminoacylation"
xref: Reactome:585829 "Mitochondrial tRNA aminoacylation"
xref: Reactome:592583 "Cytosolic tRNA aminoacylation"
xref: Reactome:592584 "tRNA Aminoacylation"
xref: Reactome:592585 "Mitochondrial tRNA aminoacylation"
xref: Reactome:595396 "Cytosolic tRNA aminoacylation"
xref: Reactome:595397 "tRNA Aminoacylation"
xref: Reactome:595398 "Mitochondrial tRNA aminoacylation"
xref: Reactome:597340 "Cytosolic tRNA aminoacylation"
xref: Reactome:597341 "tRNA Aminoacylation"
xref: Reactome:597343 "Mitochondrial tRNA aminoacylation"
xref: Reactome:598146 "Cytosolic tRNA aminoacylation"
xref: Reactome:598147 "tRNA Aminoacylation"
xref: Reactome:598149 "Mitochondrial tRNA aminoacylation"
xref: Reactome:599699 "Cytosolic tRNA aminoacylation"
xref: Reactome:599700 "tRNA Aminoacylation"
xref: Reactome:599702 "Mitochondrial tRNA aminoacylation"
xref: Reactome:600606 "Cytosolic tRNA aminoacylation"
xref: Reactome:600607 "tRNA Aminoacylation"
xref: Reactome:600609 "Mitochondrial tRNA aminoacylation"
xref: Reactome:602508 "Cytosolic tRNA aminoacylation"
xref: Reactome:602509 "tRNA Aminoacylation"
xref: Reactome:602511 "Mitochondrial tRNA aminoacylation"
is_a: GO:0043039 ! tRNA aminoacylation
relationship: part_of GO:0006412 ! translation

[Term]
id: GO:0006419
name: alanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006420
name: arginyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006421
name: asparaginyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006422
name: aspartyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006423
name: cysteinyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006424
name: glutamyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006425
name: glutaminyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006426
name: glycyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006427
name: histidyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006428
name: isoleucyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006429
name: leucyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006430
name: lysyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006431
name: methionyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006432
name: phenylalanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006433
name: prolyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006434
name: seryl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006435
name: threonyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006436
name: tryptophanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006437
name: tyrosyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006438
name: valyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510]
subset: gosubset_prok
is_a: GO:0006418 ! tRNA aminoacylation for protein translation

[Term]
id: GO:0006439
name: aminoacyl-tRNA hydrolase reaction
namespace: biological_process
def: "OBSOLETE. Hydrolysis of the peptidyl-tRNA by aminoacyl-tRNA hydrolase upon termination of translation. Analogous to usual peptidyl transfer during elongation, except that the acceptor is H2O instead of an aminoacyl-tRNA." [ISBN:019879276X]
comment: This term was made obsolete because it represents a molecular function.
is_obsolete: true
replaced_by: GO:0004045

[Term]
id: GO:0006441
name: binding to mRNA cap
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd]
comment: This term was made obsolete because it represents a function rather than a process.
is_obsolete: true
consider: GO:0000339

[Term]
id: GO:0006446
name: regulation of translational initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006417 ! regulation of translation
relationship: regulates GO:0006413 ! translational initiation

[Term]
id: GO:0006447
name: regulation of translational initiation by iron
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron." [GOC:jl]
subset: gosubset_prok
is_a: GO:0006446 ! regulation of translational initiation

[Term]
id: GO:0006448
name: regulation of translational elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006417 ! regulation of translation
relationship: regulates GO:0006414 ! translational elongation

[Term]
id: GO:0006449
name: regulation of translational termination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006417 ! regulation of translation
is_a: GO:0043244 ! regulation of protein complex disassembly
relationship: regulates GO:0006415 ! translational termination

[Term]
id: GO:0006450
name: regulation of translational fidelity
namespace: biological_process
alt_id: GO:0000029
def: "Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "regulation of translational accuracy" EXACT []
is_a: GO:0006448 ! regulation of translational elongation
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0006451
name: translational readthrough
namespace: biological_process
def: "The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons." [GOC:jsg]
subset: gosubset_prok
synonym: "natural nonsense suppression" RELATED []
is_a: GO:0006414 ! translational elongation
is_a: GO:0006417 ! regulation of translation

[Term]
id: GO:0006452
name: translational frameshifting
namespace: biological_process
def: "A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon." [GOC:hjd, ISBN:0195094425]
subset: gosubset_prok
xref: Wikipedia:Translational_frameshift
is_a: GO:0006417 ! regulation of translation

[Term]
id: GO:0006457
name: protein folding
namespace: biological_process
alt_id: GO:0007022
alt_id: GO:0007024
alt_id: GO:0007025
def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb]
subset: goslim_candida
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "alpha-tubulin folding" NARROW [GOC:mah]
synonym: "beta-tubulin folding" NARROW [GOC:mah]
synonym: "chaperone activity" RELATED []
synonym: "chaperonin ATPase activity" RELATED []
synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah]
synonym: "co-chaperone activity" RELATED []
synonym: "co-chaperonin activity" RELATED []
synonym: "glycoprotein-specific chaperone activity" RELATED []
synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED []
synonym: "protein complex assembly, multichaperone pathway" RELATED []
xref: Reactome:389960 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:389967 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:390466 "Chaperonin-mediated protein folding"
xref: Reactome:392033 "Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding"
xref: Reactome:448640 "Chaperonin-mediated protein folding"
xref: Reactome:448770 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:469768 "Chaperonin-mediated protein folding"
xref: Reactome:469885 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:487587 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:487589 "Chaperonin-mediated protein folding"
xref: Reactome:507422 "Chaperonin-mediated protein folding"
xref: Reactome:507545 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:517425 "Chaperonin-mediated protein folding"
xref: Reactome:517525 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:526299 "Chaperonin-mediated protein folding"
xref: Reactome:526394 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:531205 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:531207 "Chaperonin-mediated protein folding"
xref: Reactome:536535 "Chaperonin-mediated protein folding"
xref: Reactome:536580 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:542256 "Chaperonin-mediated protein folding"
xref: Reactome:542306 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:547600 "Chaperonin-mediated protein folding"
xref: Reactome:547647 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:552207 "Chaperonin-mediated protein folding"
xref: Reactome:552239 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:557798 "Chaperonin-mediated protein folding"
xref: Reactome:557852 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:568411 "Chaperonin-mediated protein folding"
xref: Reactome:568446 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:581613 "Chaperonin-mediated protein folding"
xref: Reactome:581659 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:585812 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:585814 "Chaperonin-mediated protein folding"
xref: Reactome:592510 "Chaperonin-mediated protein folding"
xref: Reactome:592570 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Reactome:595349 "Chaperonin-mediated protein folding"
xref: Reactome:595388 "Formation of tubulin folding intermediates by CCT/TriC"
xref: Wikipedia:Protein_folding
is_a: GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0006458
name: 'de novo' protein folding
namespace: biological_process
def: "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb]
subset: gosubset_prok
synonym: "nascent chain protein folding" EXACT []
is_a: GO:0006457 ! protein folding

[Term]
id: GO:0006459
name: binding unfolded ER proteins
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a function rather than a process.
is_obsolete: true
consider: GO:0005783
consider: GO:0051082

[Term]
id: GO:0006460
name: peptidyl-prolyl isomerase B reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
is_obsolete: true
consider: GO:0003755

[Term]
id: GO:0006461
name: protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex." [GOC:ai]
subset: goslim_pombe
subset: gosubset_prok
synonym: "chaperone activity" RELATED []
synonym: "protein complex biosynthesis" EXACT []
synonym: "protein complex formation" EXACT []
is_a: GO:0065003 ! macromolecular complex assembly
relationship: part_of GO:0070271 ! protein complex biogenesis

[Term]
id: GO:0006462
name: protein complex assembly, multichaperone pathway
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the string was ambiguous and the original meaning of the term was hence unknown.
is_obsolete: true
consider: GO:0006457
consider: GO:0051131

[Term]
id: GO:0006463
name: steroid hormone receptor complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor." [GOC:jl, Wikipedia:Steroid_hormone_receptor]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0006464
name: protein modification process
namespace: biological_process
def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "process resulting in protein modification" RELATED []
synonym: "protein tagging activity" RELATED []
xref: Reactome:163841 "Post-translational protein modification"
xref: Reactome:448468 "Post-translational protein modification"
xref: Reactome:469598 "Post-translational protein modification"
xref: Reactome:487317 "Post-translational protein modification"
xref: Reactome:507268 "Post-translational protein modification"
xref: Reactome:517285 "Post-translational protein modification"
xref: Reactome:526163 "Post-translational protein modification"
xref: Reactome:531060 "Post-translational protein modification"
xref: Reactome:536442 "Post-translational protein modification"
xref: Reactome:542137 "Post-translational protein modification"
xref: Reactome:547504 "Post-translational protein modification"
xref: Reactome:552404 "Post-translational protein modification"
xref: Reactome:557675 "Post-translational protein modification"
xref: Reactome:568295 "Post-translational protein modification"
xref: Reactome:581497 "Post-translational protein modification"
xref: Reactome:585741 "Post-translational protein modification"
xref: Reactome:592394 "Post-translational protein modification"
xref: Reactome:595284 "Post-translational protein modification"
xref: Reactome:597401 "Post-translational protein modification"
xref: Reactome:598181 "Post-translational protein modification"
is_a: GO:0043412 ! macromolecule modification
is_a: GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0006465
name: signal peptide processing
namespace: biological_process
def: "The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194]
subset: gosubset_prok
synonym: "leader peptide processing" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0044267 ! cellular protein metabolic process
is_a: GO:0051605 ! protein maturation by peptide bond cleavage

[Term]
id: GO:0006466
name: protein disulfide-isomerase reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it presents a molecular function.
synonym: "protein disulphide-isomerase reaction" EXACT []
is_obsolete: true
replaced_by: GO:0003756

[Term]
id: GO:0006467
name: protein thiol-disulfide exchange
namespace: biological_process
def: "Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond." [GOC:jsg]
subset: gosubset_prok
synonym: "disulphide bond biosynthesis" EXACT []
synonym: "disulphide bond formation" EXACT []
synonym: "protein thiol-disulphide exchange" EXACT []
is_a: GO:0006457 ! protein folding
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0006468
name: protein amino acid phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group on to a protein." [GOC:hb]
subset: gosubset_prok
is_a: GO:0016310 ! phosphorylation
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0006469
name: negative regulation of protein kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of protein kinase activity" EXACT []
synonym: "down-regulation of protein kinase activity" EXACT []
synonym: "downregulation of protein kinase activity" EXACT []
synonym: "inhibition of protein kinase activity" NARROW []
is_a: GO:0033673 ! negative regulation of kinase activity
is_a: GO:0045859 ! regulation of protein kinase activity

[Term]
id: GO:0006470
name: protein amino acid dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphoric residues from a protein." [GOC:hb]
subset: gosubset_prok
is_a: GO:0016311 ! dephosphorylation
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0006471
name: protein amino acid ADP-ribosylation
namespace: biological_process
def: "The transfer, from NAD, of ADP-ribose to protein amino acids." [RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295]
subset: gosubset_prok
xref: RESID:AA0040
xref: RESID:AA0168
xref: RESID:AA0169
xref: RESID:AA0231
xref: RESID:AA0237
xref: RESID:AA0295
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0006473
name: protein amino acid acetylation
namespace: biological_process
def: "The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043543 ! protein amino acid acylation

[Term]
id: GO:0006474
name: N-terminal protein amino acid acetylation
namespace: biological_process
def: "The acetylation of the N-terminal amino acid of proteins." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006473 ! protein amino acid acetylation
is_a: GO:0018409 ! peptide or protein amino-terminal blocking

[Term]
id: GO:0006475
name: internal protein amino acid acetylation
namespace: biological_process
def: "The addition of an acetyl group to a non-terminal amino acid in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006473 ! protein amino acid acetylation

[Term]
id: GO:0006476
name: protein amino acid deacetylation
namespace: biological_process
def: "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0006477
name: protein amino acid sulfation
namespace: biological_process
def: "The addition of a sulfate group as an ester to a protein amino acid." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "protein amino acid sulphation" EXACT []
is_a: GO:0043687 ! post-translational protein modification
is_a: GO:0051923 ! sulfation

[Term]
id: GO:0006478
name: peptidyl-tyrosine sulfation
namespace: biological_process
def: "The posttranslational sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine." [RESID:AA0172]
subset: gosubset_prok
synonym: "peptidyl-tyrosine sulphation" EXACT []
xref: RESID:AA0172
is_a: GO:0006477 ! protein amino acid sulfation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0006479
name: protein amino acid methylation
namespace: biological_process
def: "The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008213 ! protein amino acid alkylation
is_a: GO:0043414 ! macromolecule methylation

[Term]
id: GO:0006480
name: N-terminal protein amino acid methylation
namespace: biological_process
def: "The methylation of the N-terminal amino acid of a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006479 ! protein amino acid methylation
is_a: GO:0018409 ! peptide or protein amino-terminal blocking

[Term]
id: GO:0006481
name: C-terminal protein amino acid methylation
namespace: biological_process
def: "The methylation of the C-terminal amino acid of a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006479 ! protein amino acid methylation
is_a: GO:0018410 ! peptide or protein carboxyl-terminal blocking

[Term]
id: GO:0006482
name: protein amino acid demethylation
namespace: biological_process
def: "The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:mah]
subset: gosubset_prok
is_a: GO:0008214 ! protein amino acid dealkylation
is_a: GO:0070988 ! demethylation

[Term]
id: GO:0006483
name: peptidyl-aspartic acid/asparagine hydroxylation
namespace: biological_process
def: "OBSOLETE. The hydroxylation of peptidyl-aspartic acid or asparagine." [GOC:ai]
comment: This term was made obsolete because it is a redundant grouping term.
synonym: "aspartic acid/asparagine hydroxylation" EXACT []
is_obsolete: true
consider: GO:0042264
consider: GO:0042265

[Term]
id: GO:0006484
name: protein cysteine-thiol oxidation
namespace: biological_process
def: "OBSOLETE. Oxidation of two cysteine sulfhydryl groups (thiols) in one protein by a disulfide bond in a second protein to form a disulfide bond in the first protein and two reduced sulfhydryls in the second. The oxidized cysteines linked by a disulfide bond is known as cystine." [http://micro.magnet.fsu.edu/aminoacids/pages/cystine.html, http://www.indstate.edu/thcme/mwking/pentose-phosphate-pathway.html, RESID:AA0025]
comment: This term was made obsolete because it represents a single activity.
is_obsolete: true
consider: GO:0003756

[Term]
id: GO:0006486
name: protein amino acid glycosylation
namespace: biological_process
def: "A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [http://cancerweb.ncl.ac.uk/]
subset: goslim_pombe
subset: gosubset_prok
is_a: GO:0006464 ! protein modification process
is_a: GO:0043413 ! macromolecule glycosylation
is_a: GO:0044262 ! cellular carbohydrate metabolic process
relationship: part_of GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0006487
name: protein amino acid N-linked glycosylation
namespace: biological_process
def: "A protein amino acid glycosylation process in which a sugar unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [RESID:AA0151, RESID:AA0156, RESID:AA0327]
subset: gosubset_prok
synonym: "N-glycan biosynthesis" RELATED []
synonym: "N-glycan metabolism" RELATED []
xref: RESID:AA0151
xref: RESID:AA0156
xref: RESID:AA0327
is_a: GO:0006486 ! protein amino acid glycosylation

[Term]
id: GO:0006488
name: dolichol-linked oligosaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309 "Biochemical Pathways"]
subset: gosubset_prok
synonym: "dolichol-linked oligosaccharide anabolism" EXACT []
synonym: "dolichol-linked oligosaccharide biosynthesis" EXACT []
synonym: "dolichol-linked oligosaccharide formation" EXACT []
synonym: "dolichol-linked oligosaccharide synthesis" EXACT []
synonym: "N-linked glycan precursor biosynthesis" EXACT [PMID:8666161]
synonym: "N-linked glycan precursor biosynthetic process" EXACT [PMID:8666161]
synonym: "oligosaccharide-PP-dolichol assembly" EXACT []
is_a: GO:0009312 ! oligosaccharide biosynthetic process
relationship: part_of GO:0006487 ! protein amino acid N-linked glycosylation

[Term]
id: GO:0006489
name: dolichyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dolichyl diphosphate anabolism" EXACT []
synonym: "dolichyl diphosphate biosynthesis" EXACT []
synonym: "dolichyl diphosphate formation" EXACT []
synonym: "dolichyl diphosphate synthesis" EXACT []
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0019408 ! dolichol biosynthetic process
is_a: GO:0046465 ! dolichyl diphosphate metabolic process
relationship: part_of GO:0006488 ! dolichol-linked oligosaccharide biosynthetic process

[Term]
id: GO:0006490
name: oligosaccharide-lipid intermediate assembly
namespace: biological_process
def: "The cellular metabolic process by which an intermediate molecule of dolichol-P-man or dolicol-P-Glc is assembled to be used in N-linked glycosylation." [GOC:dph, GOC:hjd, GOC:isa_complete]
subset: gosubset_prok
is_a: GO:0044255 ! cellular lipid metabolic process
is_a: GO:0051691 ! cellular oligosaccharide metabolic process
relationship: part_of GO:0006488 ! dolichol-linked oligosaccharide biosynthetic process

[Term]
id: GO:0006491
name: N-glycan processing
namespace: biological_process
alt_id: GO:0006492
def: "The conversion of N-linked glycan structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198]
subset: gosubset_prok
synonym: "N-glycan catabolism" RELATED []
synonym: "N-glycan degradation" RELATED []
synonym: "N-linked glycoprotein maturation" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
relationship: part_of GO:0006487 ! protein amino acid N-linked glycosylation

[Term]
id: GO:0006493
name: protein amino acid O-linked glycosylation
namespace: biological_process
def: "A protein amino acid glycosylation process in which a sugar unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]
subset: gosubset_prok
xref: RESID:AA0153
xref: RESID:AA0154
xref: RESID:AA0155
xref: RESID:AA0157
xref: RESID:AA0212
is_a: GO:0006486 ! protein amino acid glycosylation

[Term]
id: GO:0006494
name: protein amino acid terminal glycosylation
namespace: biological_process
def: "A protein amino acid glycosylation process in which a sugar unit is added to a free alpha-amino or alpha-carboxyl terminal of a peptide." [GOC:jsg]
subset: gosubset_prok
is_a: GO:0006486 ! protein amino acid glycosylation

[Term]
id: GO:0006495
name: terminal O-glycosylation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators, GOC:jsg]
comment: This term was made obsolete because there is no evidence for the existence of this process.
is_obsolete: true

[Term]
id: GO:0006496
name: protein amino acid terminal N-glycosylation
namespace: biological_process
def: "The glycosylation of a nitrogen atom of a free alpha amino terminal of a peptide." [GOC:jsg]
comment: Note that the only known alpha amino glycosylation is on an asparagine; see UniProtKB:P58522. However, this feature is not differentiated from normal N-glycosylation of asparagine.
subset: gosubset_prok
is_a: GO:0006487 ! protein amino acid N-linked glycosylation
is_a: GO:0006494 ! protein amino acid terminal glycosylation

[Term]
id: GO:0006497
name: protein amino acid lipidation
namespace: biological_process
alt_id: GO:0042050
def: "The covalent or non-covalent attachment of lipid moieties to an amino acid in a protein." [GOC:jl]
subset: gosubset_prok
synonym: "lipid:protein modification" EXACT []
synonym: "protein lipidation" EXACT []
xref: RESID:AA0059
xref: RESID:AA0060
xref: RESID:AA0077
xref: RESID:AA0078
xref: RESID:AA0079
xref: RESID:AA0080
xref: RESID:AA0102
xref: RESID:AA0103
xref: RESID:AA0104
xref: RESID:AA0106
xref: RESID:AA0107
xref: RESID:AA0158
xref: RESID:AA0159
xref: RESID:AA0160
xref: RESID:AA0161
xref: RESID:AA0162
xref: RESID:AA0163
xref: RESID:AA0166
xref: RESID:AA0223
xref: RESID:AA0290
xref: RESID:AA0307
xref: RESID:AA0308
xref: RESID:AA0309
xref: RESID:AA0316
is_a: GO:0006464 ! protein modification process
relationship: part_of GO:0042158 ! lipoprotein biosynthetic process

[Term]
id: GO:0006498
name: N-terminal protein lipidation
namespace: biological_process
def: "The covalent or non-covalent attachment of a lipid moiety to the amino terminus of a protein." [GOC:jl]
subset: gosubset_prok
is_a: GO:0006497 ! protein amino acid lipidation
is_a: GO:0018409 ! peptide or protein amino-terminal blocking

[Term]
id: GO:0006499
name: N-terminal protein myristoylation
namespace: biological_process
def: "The covalent or non-covalent attachment of a myristoyl moiety to the N-terminal amino acid residue of a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006498 ! N-terminal protein lipidation
is_a: GO:0018319 ! protein amino acid myristoylation

[Term]
id: GO:0006500
name: N-terminal protein palmitoylation
namespace: biological_process
def: "The covalent or non-covalent attachment of a palmitoyl moiety to the N-terminal amino acid residue of a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006498 ! N-terminal protein lipidation
is_a: GO:0018318 ! protein amino acid palmitoylation

[Term]
id: GO:0006501
name: C-terminal protein lipidation
namespace: biological_process
def: "The covalent or non-covalent attachment of a lipid moiety to the carboxy terminus of a protein." [GOC:jl]
subset: gosubset_prok
xref: Reactome:163125 "Synthesis of GPI-anchored proteins"
xref: Reactome:448467 "Synthesis of GPI-anchored proteins"
xref: Reactome:469597 "Synthesis of GPI-anchored proteins"
xref: Reactome:487316 "Synthesis of GPI-anchored proteins"
xref: Reactome:507267 "Synthesis of GPI-anchored proteins"
xref: Reactome:517284 "Synthesis of GPI-anchored proteins"
xref: Reactome:526162 "Synthesis of GPI-anchored proteins"
xref: Reactome:531059 "Synthesis of GPI-anchored proteins"
xref: Reactome:536441 "Synthesis of GPI-anchored proteins"
xref: Reactome:542136 "Synthesis of GPI-anchored proteins"
xref: Reactome:547503 "Synthesis of GPI-anchored proteins"
xref: Reactome:557674 "Synthesis of GPI-anchored proteins"
xref: Reactome:568294 "Synthesis of GPI-anchored proteins"
xref: Reactome:581496 "Synthesis of GPI-anchored proteins"
xref: Reactome:585740 "Synthesis of GPI-anchored proteins"
xref: Reactome:592393 "Synthesis of GPI-anchored proteins"
xref: Reactome:595283 "Synthesis of GPI-anchored proteins"
is_a: GO:0006497 ! protein amino acid lipidation
is_a: GO:0018410 ! peptide or protein carboxyl-terminal blocking

[Term]
id: GO:0006502
name: C-terminal protein prenylation
namespace: biological_process
def: "OBSOLETE. The covalent or non-covalent attachment of a prenyl moiety to the carboxy terminus of a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:jl]
comment: This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein.
is_obsolete: true
replaced_by: GO:0018346

[Term]
id: GO:0006503
name: C-terminal protein farnesylation
namespace: biological_process
def: "OBSOLETE. The covalent or non-covalent attachment of a farnesyl moiety to the carboxy terminus of a protein." [GOC:jl]
comment: This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein.
is_obsolete: true
replaced_by: GO:0018347

[Term]
id: GO:0006504
name: C-terminal protein geranylgeranylation
namespace: biological_process
def: "OBSOLETE. The covalent or non-covalent attachment of a geranylgeranyl moiety to the carboxy terminus of a protein." [GOC:jl]
comment: This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein.
is_obsolete: true
replaced_by: GO:0018348

[Term]
id: GO:0006505
name: GPI anchor metabolic process
namespace: biological_process
alt_id: GO:0046472
def: "The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate moiety, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycosylphosphatidylinositol metabolic process" EXACT []
synonym: "glycosylphosphatidylinositol metabolism" EXACT []
synonym: "GPI anchor metabolism" EXACT []
synonym: "GPI/GSI anchor metabolic process" BROAD []
synonym: "GPI/GSI anchor metabolism" BROAD []
is_a: GO:0030384 ! phosphoinositide metabolic process

[Term]
id: GO:0006506
name: GPI anchor biosynthetic process
namespace: biological_process
alt_id: GO:0015998
def: "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684]
subset: gosubset_prok
synonym: "glycosylphosphatidylinositol biosynthesis" EXACT []
synonym: "glycosylphosphatidylinositol biosynthetic process" EXACT []
synonym: "GPI anchor anabolism" EXACT []
synonym: "GPI anchor biosynthesis" EXACT []
synonym: "GPI anchor formation" EXACT []
synonym: "GPI anchor synthesis" EXACT []
synonym: "GPI/GSI anchor biosynthesis" BROAD []
synonym: "GPI/GSI anchor biosynthetic process" BROAD []
is_a: GO:0006497 ! protein amino acid lipidation
is_a: GO:0006505 ! GPI anchor metabolic process
is_a: GO:0046489 ! phosphoinositide biosynthetic process

[Term]
id: GO:0006507
name: GPI anchor release
namespace: biological_process
subset: gosubset_prok
is_a: GO:0006505 ! GPI anchor metabolic process

[Term]
id: GO:0006508
name: proteolysis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds." [GOC:jsg, GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "ATP-dependent proteolysis" NARROW [GOC:mah]
synonym: "peptidolysis" EXACT []
xref: Reactome:159782 "Removal of aminoterminal propeptides from gamma-carboxylated proteins"
xref: Reactome:449259 "Removal of aminoterminal propeptides from gamma-carboxylated proteins"
xref: Reactome:470378 "Removal of aminoterminal propeptides from gamma-carboxylated proteins"
xref: Reactome:488060 "Removal of aminoterminal propeptides from gamma-carboxylated proteins"
xref: Reactome:508017 "Removal of aminoterminal propeptides from gamma-carboxylated proteins"
xref: Reactome:517878 "Removal of aminoterminal propeptides from gamma-carboxylated proteins"
xref: Wikipedia:Proteolysis
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0006509
name: membrane protein ectodomain proteolysis
namespace: biological_process
def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/]
subset: gosubset_prok
synonym: "membrane protein solubilization" RELATED []
synonym: "receptor shedding" RELATED []
is_a: GO:0033619 ! membrane protein proteolysis

[Term]
id: GO:0006510
name: ATP-dependent proteolysis
namespace: biological_process
def: "OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein using energy from the hydrolysis of ATP." [GOC:jl]
comment: This term was made obsolete because it represents a molecular function.
synonym: "ATP-dependent peptidolysis" EXACT []
is_obsolete: true
replaced_by: GO:0004176
consider: GO:0006508
consider: GO:0051603
consider: GO:0051605

[Term]
id: GO:0006511
name: ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein." [GOC:go_curators]
synonym: "ubiquitin-dependent protein breakdown" EXACT []
synonym: "ubiquitin-dependent protein catabolism" EXACT []
synonym: "ubiquitin-dependent protein degradation" EXACT []
synonym: "ubiquitin-dependent proteolysis" EXACT []
is_a: GO:0019941 ! modification-dependent protein catabolic process

[Term]
id: GO:0006512
name: ubiquitin cycle
namespace: biological_process
def: "OBSOLETE. The cyclical process by which one or more ubiquitin moieties are added to (ubiquitination) and removed from (deubiquitination) a protein." [PMID:11917093]
comment: This term was made obsolete because it implies that every protein that is ubiquitinated is also subsequently deubiquinitated, which is not true. Also, the process ontology does not include analogous terms for other small modifiers.
is_obsolete: true

[Term]
id: GO:0006513
name: protein monoubiquitination
namespace: biological_process
def: "Addition of a single ubiquitin moiety to a protein." [GOC:ai]
synonym: "protein monoubiquitinylation" EXACT []
synonym: "protein monoubiquitylation" EXACT []
is_a: GO:0016567 ! protein ubiquitination

[Term]
id: GO:0006515
name: misfolded or incompletely synthesized protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl]
subset: gosubset_prok
synonym: "degradation of misfolded or incompletely synthesized proteins" EXACT []
synonym: "misfolded or incompletely synthesized protein breakdown" EXACT []
synonym: "misfolded or incompletely synthesized protein catabolism" EXACT []
synonym: "misfolded or incompletely synthesized protein degradation" EXACT []
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process

[Term]
id: GO:0006516
name: glycoprotein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycoprotein breakdown" EXACT []
synonym: "glycoprotein catabolism" EXACT []
synonym: "glycoprotein degradation" EXACT []
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:0006517
name: protein deglycosylation
namespace: biological_process
def: "The removal of sugar residues from a glycosylated protein." [GOC:mah]
subset: gosubset_prok
synonym: "glycoprotein deglycosylation" EXACT []
is_a: GO:0006464 ! protein modification process
is_a: GO:0006516 ! glycoprotein catabolic process

[Term]
id: GO:0006518
name: peptide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
subset: goslim_pir
subset: gosubset_prok
synonym: "peptide metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006519
name: cellular amino acid and derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "amino acid and derivative metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044238 ! primary metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0006520
name: cellular amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pombe
subset: gosubset_prok
synonym: "cellular amino acid metabolism" EXACT []
is_a: GO:0006519 ! cellular amino acid and derivative metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0044106 ! cellular amine metabolic process

[Term]
id: GO:0006521
name: regulation of cellular amino acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of amino acid metabolism" EXACT []
xref: Reactome:350562 "Regulation of ornithine decarboxylase (ODC)"
xref: Reactome:448570 "Regulation of ornithine decarboxylase (ODC)"
xref: Reactome:469699 "Regulation of ornithine decarboxylase (ODC)"
xref: Reactome:487626 "Regulation of ornithine decarboxylase (ODC)"
xref: Reactome:507366 "Regulation of ornithine decarboxylase (ODC)"
xref: Reactome:517852 "Regulation of ornithine decarboxylase (ODC)"
xref: Reactome:526682 "Regulation of ornithine decarboxylase (ODC)"
xref: Reactome:531458 "Regulation of ornithine decarboxylase (ODC)"
xref: Reactome:536841 "Regulation of ornithine decarboxylase (ODC)"
xref: Reactome:542596 "Regulation of ornithine decarboxylase (ODC)"
xref: Reactome:547914 "Regulation of ornithine decarboxylase (ODC)"
xref: Reactome:552497 "Regulation of ornithine decarboxylase (ODC)"
xref: Reactome:558115 "Regulation of ornithine decarboxylase (ODC)"
xref: Reactome:581948 "Regulation of ornithine decarboxylase (ODC)"
xref: Reactome:585990 "Regulation of ornithine decarboxylase (ODC)"
xref: Reactome:592851 "Regulation of ornithine decarboxylase (ODC)"
xref: Reactome:595564 "Regulation of ornithine decarboxylase (ODC)"
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0006522
name: alanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alanine, 2-aminopropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "alanine metabolism" EXACT []
xref: Reactome:448782 "Alanine metabolism"
xref: Reactome:469897 "Alanine metabolism"
xref: Reactome:487604 "Alanine metabolism"
xref: Reactome:507559 "Alanine metabolism"
xref: Reactome:517537 "Alanine metabolism"
xref: Reactome:526404 "Alanine metabolism"
xref: Reactome:531224 "Alanine metabolism"
xref: Reactome:536594 "Alanine metabolism"
xref: Reactome:542320 "Alanine metabolism"
xref: Reactome:547660 "Alanine metabolism"
xref: Reactome:552245 "Alanine metabolism"
xref: Reactome:557864 "Alanine metabolism"
xref: Reactome:568462 "Alanine metabolism"
xref: Reactome:581673 "Alanine metabolism"
xref: Reactome:585824 "Alanine metabolism"
xref: Reactome:592582 "Alanine metabolism"
xref: Reactome:598145 "Alanine metabolism"
xref: Reactome:70525 "Alanine metabolism"
is_a: GO:0009078 ! pyruvate family amino acid metabolic process

[Term]
id: GO:0006523
name: alanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "alanine anabolism" EXACT []
synonym: "alanine biosynthesis" EXACT []
synonym: "alanine formation" EXACT []
synonym: "alanine synthesis" EXACT []
is_a: GO:0006522 ! alanine metabolic process
is_a: GO:0009079 ! pyruvate family amino acid biosynthetic process

[Term]
id: GO:0006524
name: alanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "alanine breakdown" EXACT []
synonym: "alanine catabolism" EXACT []
synonym: "alanine degradation" EXACT []
is_a: GO:0006522 ! alanine metabolic process
is_a: GO:0009080 ! pyruvate family amino acid catabolic process

[Term]
id: GO:0006525
name: arginine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ChEBI:29016, GOC:go_curators]
subset: gosubset_prok
synonym: "arginine metabolism" EXACT []
xref: Wikipedia:Arginine
is_a: GO:0009064 ! glutamine family amino acid metabolic process

[Term]
id: GO:0006526
name: arginine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ChEBI:29016, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "arginine anabolism" EXACT []
synonym: "arginine biosynthesis" EXACT []
synonym: "arginine formation" EXACT []
synonym: "arginine synthesis" EXACT []
xref: MetaCyc:ARGININE-SYN4-PWY
xref: MetaCyc:ARGSYN-PWY
xref: MetaCyc:ARGSYNBSUB-PWY
is_a: GO:0006525 ! arginine metabolic process
is_a: GO:0009084 ! glutamine family amino acid biosynthetic process

[Term]
id: GO:0006527
name: arginine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ChEBI:29016, GOC:go_curators]
subset: gosubset_prok
synonym: "arginine breakdown" EXACT []
synonym: "arginine catabolism" EXACT []
synonym: "arginine degradation" EXACT []
is_a: GO:0006525 ! arginine metabolic process
is_a: GO:0009065 ! glutamine family amino acid catabolic process

[Term]
id: GO:0006528
name: asparagine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "asparagine metabolism" EXACT []
xref: MetaCyc:ASPARAGINESYN-PWY
is_a: GO:0009066 ! aspartate family amino acid metabolic process

[Term]
id: GO:0006529
name: asparagine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "asparagine anabolism" EXACT []
synonym: "asparagine biosynthesis" EXACT []
synonym: "asparagine formation" EXACT []
synonym: "asparagine synthesis" EXACT []
is_a: GO:0006528 ! asparagine metabolic process
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process

[Term]
id: GO:0006530
name: asparagine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "asparagine breakdown" EXACT []
synonym: "asparagine catabolism" EXACT []
synonym: "asparagine degradation" EXACT []
is_a: GO:0006528 ! asparagine metabolic process
is_a: GO:0009065 ! glutamine family amino acid catabolic process
is_a: GO:0009068 ! aspartate family amino acid catabolic process

[Term]
id: GO:0006531
name: aspartate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aspartate metabolism" EXACT []
is_a: GO:0009066 ! aspartate family amino acid metabolic process

[Term]
id: GO:0006532
name: aspartate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aspartate anabolism" EXACT []
synonym: "aspartate biosynthesis" EXACT []
synonym: "aspartate formation" EXACT []
synonym: "aspartate synthesis" EXACT []
is_a: GO:0006531 ! aspartate metabolic process
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process

[Term]
id: GO:0006533
name: aspartate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aspartate breakdown" EXACT []
synonym: "aspartate catabolism" EXACT []
synonym: "aspartate degradation" EXACT []
is_a: GO:0006531 ! aspartate metabolic process
is_a: GO:0009068 ! aspartate family amino acid catabolic process

[Term]
id: GO:0006534
name: cysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "cysteine metabolism" EXACT []
xref: Wikipedia:Cysteine_metabolism
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0006535
name: cysteine biosynthetic process from serine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators]
subset: gosubset_prok
synonym: "cysteine anabolism from serine" EXACT []
synonym: "cysteine formation from serine" EXACT []
synonym: "cysteine synthesis from serine" EXACT []
xref: MetaCyc:CYSTSYN-PWY
is_a: GO:0006563 ! L-serine metabolic process
is_a: GO:0019344 ! cysteine biosynthetic process

[Term]
id: GO:0006536
name: glutamate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate metabolism" EXACT []
synonym: "glutamic acid metabolic process" EXACT []
synonym: "glutamic acid metabolism" EXACT []
xref: Wikipedia:Glutamic_acid
is_a: GO:0009064 ! glutamine family amino acid metabolic process

[Term]
id: GO:0006537
name: glutamate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate anabolism" EXACT []
synonym: "glutamate biosynthesis" EXACT []
synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" NARROW []
synonym: "glutamate biosynthesis, using glutamate synthase (NADPH)" NARROW []
synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" NARROW []
synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" NARROW []
synonym: "glutamate formation" EXACT []
synonym: "glutamate synthesis" EXACT []
synonym: "glutamic acid biosynthesis" EXACT []
synonym: "glutamic acid biosynthetic process" EXACT []
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0009084 ! glutamine family amino acid biosynthetic process

[Term]
id: GO:0006538
name: glutamate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate breakdown" EXACT []
synonym: "glutamate catabolism" EXACT []
synonym: "glutamate degradation" EXACT []
synonym: "glutamic acid catabolic process" EXACT []
synonym: "glutamic acid catabolism" EXACT []
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0009065 ! glutamine family amino acid catabolic process

[Term]
id: GO:0006539
name: glutamate catabolic process via 2-oxoglutarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate breakdown via 2-oxoglutarate" EXACT []
synonym: "glutamate catabolic process via 2-ketoglutarate" EXACT []
synonym: "glutamate catabolic process via alpha-ketoglutarate" EXACT []
synonym: "glutamate catabolic process via alpha-oxoglutarate" EXACT []
synonym: "glutamate catabolism via 2-ketoglutarate" EXACT []
synonym: "glutamate catabolism via alpha-ketoglutarate" EXACT []
synonym: "glutamate catabolism via alpha-oxoglutarate" EXACT []
synonym: "glutamate degradation via 2-oxoglutarate" EXACT []
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0006538 ! glutamate catabolic process

[Term]
id: GO:0006540
name: glutamate decarboxylation to succinate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes." [PMID:12740438]
subset: gosubset_prok
synonym: "4-aminobutyrate shunt" EXACT []
synonym: "GABA shunt" EXACT []
synonym: "gamma-aminobutyrate shunt" EXACT []
xref: MetaCyc:GLUDEG-I-PWY
xref: MetaCyc:PWY-4321
is_a: GO:0006105 ! succinate metabolic process
is_a: GO:0006538 ! glutamate catabolic process

[Term]
id: GO:0006541
name: glutamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "glutamine metabolism" EXACT []
is_a: GO:0009064 ! glutamine family amino acid metabolic process

[Term]
id: GO:0006542
name: glutamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "glutamine anabolism" EXACT []
synonym: "glutamine biosynthesis" EXACT []
synonym: "glutamine formation" EXACT []
synonym: "glutamine synthesis" EXACT []
xref: MetaCyc:GLNSYN-PWY
is_a: GO:0006541 ! glutamine metabolic process
is_a: GO:0009084 ! glutamine family amino acid biosynthetic process

[Term]
id: GO:0006543
name: glutamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "glutamine breakdown" EXACT []
synonym: "glutamine catabolism" EXACT []
synonym: "glutamine degradation" EXACT []
is_a: GO:0006541 ! glutamine metabolic process
is_a: GO:0009065 ! glutamine family amino acid catabolic process

[Term]
id: GO:0006544
name: glycine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycine metabolism" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0006545
name: glycine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycine anabolism" EXACT []
synonym: "glycine biosynthesis" EXACT []
synonym: "glycine formation" EXACT []
synonym: "glycine synthesis" EXACT []
xref: MetaCyc:GLYCINE-SYN2-PWY
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0009070 ! serine family amino acid biosynthetic process

[Term]
id: GO:0006546
name: glycine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycine breakdown" EXACT []
synonym: "glycine catabolism" EXACT []
synonym: "glycine degradation" EXACT []
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0009071 ! serine family amino acid catabolic process

[Term]
id: GO:0006547
name: histidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine metabolism" EXACT []
xref: Wikipedia:Histidine
is_a: GO:0009075 ! histidine family amino acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0006548
name: histidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine breakdown" EXACT []
synonym: "histidine catabolism" EXACT []
synonym: "histidine degradation" EXACT []
xref: Reactome:448592 "Histidine catabolism"
xref: Reactome:469721 "Histidine catabolism"
xref: Reactome:487432 "Histidine catabolism"
xref: Reactome:507389 "Histidine catabolism"
xref: Reactome:526266 "Histidine catabolism"
xref: Reactome:542549 "Histidine catabolism"
xref: Reactome:568707 "Histidine catabolism"
xref: Reactome:581910 "Histidine catabolism"
xref: Reactome:585948 "Histidine catabolism"
xref: Reactome:592482 "Histidine catabolism"
xref: Reactome:70921 "Histidine catabolism"
is_a: GO:0006547 ! histidine metabolic process
is_a: GO:0009077 ! histidine family amino acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0006549
name: isoleucine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "isoleucine metabolism" EXACT []
is_a: GO:0009081 ! branched chain family amino acid metabolic process

[Term]
id: GO:0006550
name: isoleucine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "isoleucine breakdown" EXACT []
synonym: "isoleucine catabolism" EXACT []
synonym: "isoleucine degradation" EXACT []
xref: MetaCyc:ILEUDEG-PWY
xref: Reactome:448561 "Isoleucine catabolism"
xref: Reactome:469690 "Isoleucine catabolism"
xref: Reactome:487402 "Isoleucine catabolism"
xref: Reactome:507354 "Isoleucine catabolism"
xref: Reactome:517364 "Isoleucine catabolism"
xref: Reactome:526242 "Isoleucine catabolism"
xref: Reactome:531119 "Isoleucine catabolism"
xref: Reactome:536606 "Isoleucine catabolism"
xref: Reactome:542201 "Isoleucine catabolism"
xref: Reactome:547670 "Isoleucine catabolism"
xref: Reactome:552157 "Isoleucine catabolism"
xref: Reactome:557745 "Isoleucine catabolism"
xref: Reactome:568362 "Isoleucine catabolism"
xref: Reactome:581564 "Isoleucine catabolism"
xref: Reactome:592460 "Isoleucine catabolism"
xref: Reactome:595327 "Isoleucine catabolism"
xref: Reactome:597345 "Isoleucine catabolism"
xref: Reactome:598191 "Isoleucine catabolism"
xref: Reactome:599706 "Isoleucine catabolism"
xref: Reactome:600664 "Isoleucine catabolism"
xref: Reactome:602444 "Isoleucine catabolism"
xref: Reactome:70845 "Isoleucine catabolism"
is_a: GO:0006549 ! isoleucine metabolic process
is_a: GO:0009083 ! branched chain family amino acid catabolic process

[Term]
id: GO:0006551
name: leucine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "leucine metabolism" EXACT []
is_a: GO:0009081 ! branched chain family amino acid metabolic process

[Term]
id: GO:0006552
name: leucine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "leucine breakdown" EXACT []
synonym: "leucine catabolism" EXACT []
synonym: "leucine degradation" EXACT []
xref: MetaCyc:LEU-DEG2-PWY
xref: Reactome:448587 "Leucine catabolism"
xref: Reactome:469716 "Leucine catabolism"
xref: Reactome:487428 "Leucine catabolism"
xref: Reactome:507384 "Leucine catabolism"
xref: Reactome:517384 "Leucine catabolism"
xref: Reactome:526261 "Leucine catabolism"
xref: Reactome:531134 "Leucine catabolism"
xref: Reactome:536812 "Leucine catabolism"
xref: Reactome:542221 "Leucine catabolism"
xref: Reactome:547891 "Leucine catabolism"
xref: Reactome:552182 "Leucine catabolism"
xref: Reactome:557767 "Leucine catabolism"
xref: Reactome:568379 "Leucine catabolism"
xref: Reactome:581581 "Leucine catabolism"
xref: Reactome:592476 "Leucine catabolism"
xref: Reactome:595335 "Leucine catabolism"
xref: Reactome:598199 "Leucine catabolism"
xref: Reactome:599764 "Leucine catabolism"
xref: Reactome:600673 "Leucine catabolism"
xref: Reactome:602463 "Leucine catabolism"
xref: Reactome:70793 "Leucine catabolism"
is_a: GO:0006551 ! leucine metabolic process
is_a: GO:0009083 ! branched chain family amino acid catabolic process

[Term]
id: GO:0006553
name: lysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "lysine metabolism" EXACT []
xref: Wikipedia:Lysine
is_a: GO:0009066 ! aspartate family amino acid metabolic process

[Term]
id: GO:0006554
name: lysine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "lysine breakdown" EXACT []
synonym: "lysine catabolism" EXACT []
synonym: "lysine degradation" EXACT []
xref: Reactome:448479 "Lysine catabolism"
xref: Reactome:448590 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:469609 "Lysine catabolism"
xref: Reactome:469719 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:487328 "Lysine catabolism"
xref: Reactome:487431 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:507279 "Lysine catabolism"
xref: Reactome:507387 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:517368 "Lysine catabolism"
xref: Reactome:517390 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:526178 "Lysine catabolism"
xref: Reactome:526264 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:531068 "Lysine catabolism"
xref: Reactome:531137 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:536494 "Lysine catabolism"
xref: Reactome:536509 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:542145 "Lysine catabolism"
xref: Reactome:542224 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:547558 "Lysine catabolism"
xref: Reactome:547573 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:552101 "Lysine catabolism"
xref: Reactome:552185 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:557685 "Lysine catabolism"
xref: Reactome:557770 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:568303 "Lysine catabolism"
xref: Reactome:568382 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:581505 "Lysine catabolism"
xref: Reactome:581584 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:592399 "Lysine catabolism"
xref: Reactome:592479 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:595336 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:595337 "Lysine catabolism"
xref: Reactome:597259 "Lysine catabolism"
xref: Reactome:599590 "Lysine catabolism"
xref: Reactome:599650 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:602401 "Lysine catabolism"
xref: Reactome:602464 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:71037 "Oxidative decarboxylation of alpha-ketoadipate to glutaryl CoA by alpha-ketoglutarate dehydrogenase"
xref: Reactome:71064 "Lysine catabolism"
is_a: GO:0006553 ! lysine metabolic process
is_a: GO:0009068 ! aspartate family amino acid catabolic process

[Term]
id: GO:0006555
name: methionine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "methionine and threonine metabolic process" BROAD []
synonym: "methionine and threonine metabolism" BROAD []
synonym: "methionine metabolism" EXACT []
xref: UM-BBD_pathwayID:met
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0009066 ! aspartate family amino acid metabolic process

[Term]
id: GO:0006556
name: S-adenosylmethionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "S-adenosyl methionine biosynthesis" EXACT []
synonym: "S-adenosyl methionine biosynthetic process" EXACT []
synonym: "S-adenosylmethionine anabolism" EXACT []
synonym: "S-adenosylmethionine biosynthesis" EXACT []
synonym: "S-adenosylmethionine formation" EXACT []
synonym: "S-adenosylmethionine synthesis" EXACT []
synonym: "SAM biosynthetic process" EXACT []
xref: MetaCyc:SAM-PWY
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046500 ! S-adenosylmethionine metabolic process
relationship: part_of GO:0000097 ! sulfur amino acid biosynthetic process

[Term]
id: GO:0006557
name: S-adenosylmethioninamine biosynthetic process
namespace: biological_process
alt_id: GO:0006745
def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE]
subset: gosubset_prok
synonym: "S-adenosylmethioninamine anabolism" EXACT []
synonym: "S-adenosylmethioninamine biosynthesis" EXACT []
synonym: "S-adenosylmethioninamine formation" EXACT []
synonym: "S-adenosylmethioninamine synthesis" EXACT []
is_a: GO:0006743 ! ubiquinone metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046499 ! S-adenosylmethioninamine metabolic process

[Term]
id: GO:0006558
name: L-phenylalanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [ChEBI:17295, GOC:go_curators, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-phenylalanine metabolism" EXACT []
synonym: "phenylalanine metabolic process" BROAD []
synonym: "phenylalanine metabolism" BROAD []
is_a: GO:0009072 ! aromatic amino acid family metabolic process

[Term]
id: GO:0006559
name: L-phenylalanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-phenylalanine breakdown" EXACT []
synonym: "L-phenylalanine catabolism" EXACT []
synonym: "L-phenylalanine degradation" EXACT []
synonym: "phenylalanine catabolic process" BROAD []
synonym: "phenylalanine catabolism" BROAD []
xref: Reactome:448593 "Phenylalanine and tyrosine catabolism"
xref: Reactome:469722 "Phenylalanine and tyrosine catabolism"
xref: Reactome:487433 "Phenylalanine and tyrosine catabolism"
xref: Reactome:507390 "Phenylalanine and tyrosine catabolism"
xref: Reactome:517392 "Phenylalanine and tyrosine catabolism"
xref: Reactome:526267 "Phenylalanine and tyrosine catabolism"
xref: Reactome:536511 "Phenylalanine and tyrosine catabolism"
xref: Reactome:542539 "Phenylalanine and tyrosine catabolism"
xref: Reactome:547579 "Phenylalanine and tyrosine catabolism"
xref: Reactome:552188 "Phenylalanine and tyrosine catabolism"
xref: Reactome:557773 "Phenylalanine and tyrosine catabolism"
xref: Reactome:568385 "Phenylalanine and tyrosine catabolism"
xref: Reactome:581587 "Phenylalanine and tyrosine catabolism"
xref: Reactome:592483 "Phenylalanine and tyrosine catabolism"
xref: Reactome:597304 "Phenylalanine and tyrosine catabolism"
xref: Reactome:599788 "Phenylalanine and tyrosine catabolism"
xref: Reactome:600585 "Phenylalanine and tyrosine catabolism"
xref: Reactome:602468 "Phenylalanine and tyrosine catabolism"
xref: Reactome:71182 "Phenylalanine and tyrosine catabolism"
is_a: GO:0006558 ! L-phenylalanine metabolic process
is_a: GO:0009074 ! aromatic amino acid family catabolic process

[Term]
id: GO:0006560
name: proline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "proline metabolism" EXACT []
is_a: GO:0009064 ! glutamine family amino acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0006561
name: proline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "proline anabolism" EXACT []
synonym: "proline biosynthesis" EXACT []
synonym: "proline formation" EXACT []
synonym: "proline synthesis" EXACT []
xref: MetaCyc:PROSYN-PWY
xref: MetaCyc:PWY-3341
xref: Reactome:449173 "Proline synthesis"
xref: Reactome:470286 "Proline synthesis"
xref: Reactome:487962 "Proline synthesis"
xref: Reactome:507936 "Proline synthesis"
xref: Reactome:517808 "Proline synthesis"
xref: Reactome:526640 "Proline synthesis"
xref: Reactome:531438 "Proline synthesis"
xref: Reactome:536811 "Proline synthesis"
xref: Reactome:542570 "Proline synthesis"
xref: Reactome:547890 "Proline synthesis"
xref: Reactome:552469 "Proline synthesis"
xref: Reactome:558077 "Proline synthesis"
xref: Reactome:568725 "Proline synthesis"
xref: Reactome:581928 "Proline synthesis"
xref: Reactome:592820 "Proline synthesis"
xref: Reactome:595543 "Proline synthesis"
xref: Reactome:597426 "Proline synthesis"
xref: Reactome:598209 "Proline synthesis"
xref: Reactome:599765 "Proline synthesis"
xref: Reactome:600672 "Proline synthesis"
xref: Reactome:602580 "Proline synthesis"
xref: Reactome:70665 "Proline synthesis"
is_a: GO:0006560 ! proline metabolic process
is_a: GO:0009084 ! glutamine family amino acid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process

[Term]
id: GO:0006562
name: proline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "proline breakdown" EXACT []
synonym: "proline catabolism" EXACT []
synonym: "proline degradation" EXACT []
xref: Reactome:449128 "Proline catabolism"
xref: Reactome:470239 "Proline catabolism"
xref: Reactome:487922 "Proline catabolism"
xref: Reactome:507893 "Proline catabolism"
xref: Reactome:517785 "Proline catabolism"
xref: Reactome:526615 "Proline catabolism"
xref: Reactome:531415 "Proline catabolism"
xref: Reactome:536786 "Proline catabolism"
xref: Reactome:542543 "Proline catabolism"
xref: Reactome:547871 "Proline catabolism"
xref: Reactome:552444 "Proline catabolism"
xref: Reactome:558056 "Proline catabolism"
xref: Reactome:568701 "Proline catabolism"
xref: Reactome:581904 "Proline catabolism"
xref: Reactome:592802 "Proline catabolism"
xref: Reactome:595530 "Proline catabolism"
xref: Reactome:597413 "Proline catabolism"
xref: Reactome:598182 "Proline catabolism"
xref: Reactome:599754 "Proline catabolism"
xref: Reactome:600655 "Proline catabolism"
xref: Reactome:602564 "Proline catabolism"
xref: Reactome:70688 "Proline catabolism"
is_a: GO:0006560 ! proline metabolic process
is_a: GO:0009065 ! glutamine family amino acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0006563
name: L-serine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [ChEBI:17115, GOC:ai, GOC:jsg]
subset: gosubset_prok
synonym: "L-serine metabolism" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0006564
name: L-serine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [ChEBI:17115, GOC:ai, GOC:jsg]
subset: gosubset_prok
synonym: "L-serine anabolism" EXACT []
synonym: "L-serine biosynthesis" EXACT []
synonym: "L-serine formation" EXACT []
synonym: "L-serine synthesis" EXACT []
xref: MetaCyc:SERSYN-PWY
is_a: GO:0006563 ! L-serine metabolic process
is_a: GO:0009070 ! serine family amino acid biosynthetic process

[Term]
id: GO:0006565
name: L-serine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [ChEBI:17115, GOC:ai, GOC:jsg]
subset: gosubset_prok
synonym: "L-serine breakdown" EXACT []
synonym: "L-serine catabolism" EXACT []
synonym: "L-serine degradation" EXACT []
xref: MetaCyc:SERDEG-PWY
is_a: GO:0006563 ! L-serine metabolic process
is_a: GO:0009071 ! serine family amino acid catabolic process

[Term]
id: GO:0006566
name: threonine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "methionine and threonine metabolic process" BROAD []
synonym: "methionine and threonine metabolism" BROAD []
synonym: "threonine metabolism" EXACT []
xref: UM-BBD_pathwayID:met
is_a: GO:0009066 ! aspartate family amino acid metabolic process

[Term]
id: GO:0006567
name: threonine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "threonine breakdown" EXACT []
synonym: "threonine catabolism" EXACT []
synonym: "threonine degradation" EXACT []
xref: MetaCyc:THREOCAT-PWY
xref: UM-BBD_pathwayID:met
is_a: GO:0006566 ! threonine metabolic process
is_a: GO:0009068 ! aspartate family amino acid catabolic process

[Term]
id: GO:0006568
name: tryptophan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684]
subset: gosubset_prok
synonym: "tryptophan metabolism" EXACT []
xref: Wikipedia:Tryptophan
is_a: GO:0006586 ! indolalkylamine metabolic process
is_a: GO:0009072 ! aromatic amino acid family metabolic process

[Term]
id: GO:0006569
name: tryptophan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684]
subset: gosubset_prok
synonym: "tryptophan breakdown" EXACT []
synonym: "tryptophan catabolic process, using tryptophanase" NARROW []
synonym: "tryptophan catabolism" EXACT []
synonym: "tryptophan catabolism, using tryptophanase" NARROW []
synonym: "tryptophan degradation" EXACT []
xref: Reactome:448558 "Tryptophan catabolism"
xref: Reactome:469687 "Tryptophan catabolism"
xref: Reactome:487399 "Tryptophan catabolism"
xref: Reactome:507351 "Tryptophan catabolism"
xref: Reactome:517361 "Tryptophan catabolism"
xref: Reactome:526239 "Tryptophan catabolism"
xref: Reactome:531116 "Tryptophan catabolism"
xref: Reactome:536504 "Tryptophan catabolism"
xref: Reactome:542197 "Tryptophan catabolism"
xref: Reactome:552178 "Tryptophan catabolism"
xref: Reactome:558076 "Tryptophan catabolism"
xref: Reactome:568740 "Tryptophan catabolism"
xref: Reactome:581943 "Tryptophan catabolism"
xref: Reactome:592457 "Tryptophan catabolism"
xref: Reactome:602600 "Tryptophan catabolism"
xref: Reactome:71240 "Tryptophan catabolism"
is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0009074 ! aromatic amino acid family catabolic process
is_a: GO:0046218 ! indolalkylamine catabolic process

[Term]
id: GO:0006570
name: tyrosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "tyrosine metabolism" EXACT []
xref: UM-BBD_pathwayID:tyr
xref: Wikipedia:Tyrosine
is_a: GO:0009072 ! aromatic amino acid family metabolic process

[Term]
id: GO:0006571
name: tyrosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:sm]
subset: gosubset_prok
synonym: "tyrosine anabolism" EXACT []
synonym: "tyrosine biosynthesis" EXACT []
synonym: "tyrosine formation" EXACT []
synonym: "tyrosine synthesis" EXACT []
xref: MetaCyc:PWY-3461
is_a: GO:0006570 ! tyrosine metabolic process
is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway

[Term]
id: GO:0006572
name: tyrosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "tyrosine breakdown" EXACT []
synonym: "tyrosine catabolism" EXACT []
synonym: "tyrosine degradation" EXACT []
is_a: GO:0006570 ! tyrosine metabolic process
is_a: GO:0009074 ! aromatic amino acid family catabolic process

[Term]
id: GO:0006573
name: valine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "valine metabolism" EXACT []
is_a: GO:0009081 ! branched chain family amino acid metabolic process

[Term]
id: GO:0006574
name: valine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "valine breakdown" EXACT []
synonym: "valine catabolism" EXACT []
synonym: "valine degradation" EXACT []
xref: MetaCyc:VALDEG-PWY
xref: Reactome:448564 "Valine catabolism"
xref: Reactome:469693 "Valine catabolism"
xref: Reactome:487405 "Valine catabolism"
xref: Reactome:507357 "Valine catabolism"
xref: Reactome:517367 "Valine catabolism"
xref: Reactome:526245 "Valine catabolism"
xref: Reactome:531122 "Valine catabolism"
xref: Reactome:536646 "Valine catabolism"
xref: Reactome:542204 "Valine catabolism"
xref: Reactome:547719 "Valine catabolism"
xref: Reactome:552160 "Valine catabolism"
xref: Reactome:557748 "Valine catabolism"
xref: Reactome:568365 "Valine catabolism"
xref: Reactome:581567 "Valine catabolism"
xref: Reactome:592463 "Valine catabolism"
xref: Reactome:595330 "Valine catabolism"
xref: Reactome:597370 "Valine catabolism"
xref: Reactome:598224 "Valine catabolism"
xref: Reactome:599723 "Valine catabolism"
xref: Reactome:600627 "Valine catabolism"
xref: Reactome:602447 "Valine catabolism"
xref: Reactome:70894 "Valine catabolism"
is_a: GO:0006573 ! valine metabolic process
is_a: GO:0009083 ! branched chain family amino acid catabolic process

[Term]
id: GO:0006575
name: cellular amino acid derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]
subset: gosubset_prok
synonym: "cellular amino acid derivative metabolism" EXACT []
synonym: "cellular modified amino acid metabolic process" EXACT [ChEBI:25359, GOC:mah]
is_a: GO:0006519 ! cellular amino acid and derivative metabolic process

[Term]
id: GO:0006576
name: cellular biogenic amine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172]
subset: gosubset_prok
synonym: "biogenic amine metabolism" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0044106 ! cellular amine metabolic process

[Term]
id: GO:0006577
name: betaine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "betaine metabolism" EXACT []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0006578
name: betaine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "betaine anabolism" EXACT []
synonym: "betaine biosynthesis" EXACT []
synonym: "betaine formation" EXACT []
synonym: "betaine synthesis" EXACT []
is_a: GO:0006577 ! betaine metabolic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process

[Term]
id: GO:0006579
name: betaine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "betaine breakdown" EXACT []
synonym: "betaine catabolism" EXACT []
synonym: "betaine degradation" EXACT []
is_a: GO:0006577 ! betaine metabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process

[Term]
id: GO:0006580
name: ethanolamine metabolic process
namespace: biological_process
alt_id: GO:0006645
def: "The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [ChEBI:16000, GOC:jl, ISBN:01928006X]
subset: gosubset_prok
synonym: "ethanolamine metabolism" EXACT []
is_a: GO:0042439 ! ethanolamine and derivative metabolic process

[Term]
id: GO:0006581
name: acetylcholine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752]
synonym: "acetylcholine breakdown" EXACT []
synonym: "acetylcholine catabolism" EXACT []
synonym: "acetylcholine degradation" EXACT []
is_a: GO:0008291 ! acetylcholine metabolic process
is_a: GO:0042135 ! neurotransmitter catabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process

[Term]
id: GO:0006582
name: melanin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [GOC:go_curators]
subset: gosubset_prok
synonym: "melanin metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0006583
name: melanin biosynthetic process from tyrosine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators]
subset: gosubset_prok
synonym: "melanin anabolism from tyrosine" EXACT []
synonym: "melanin formation from tyrosine" EXACT []
synonym: "melanin synthesis from tyrosine" EXACT []
is_a: GO:0006570 ! tyrosine metabolic process
is_a: GO:0042438 ! melanin biosynthetic process

[Term]
id: GO:0006584
name: catecholamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "catecholamine metabolism" EXACT []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
is_a: GO:0009712 ! catechol metabolic process

[Term]
id: GO:0006585
name: dopamine biosynthetic process from tyrosine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine." [GOC:bf, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "dopamine anabolism from tyrosine" EXACT []
synonym: "dopamine formation from tyrosine" EXACT []
synonym: "dopamine synthesis from tyrosine" EXACT []
is_a: GO:0006570 ! tyrosine metabolic process
is_a: GO:0042416 ! dopamine biosynthetic process

[Term]
id: GO:0006586
name: indolalkylamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "indolalkylamine metabolism" EXACT []
synonym: "indolamine metabolic process" BROAD []
synonym: "indolamine metabolism" BROAD []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
is_a: GO:0042434 ! indole derivative metabolic process

[Term]
id: GO:0006587
name: serotonin biosynthetic process from tryptophan
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "serotonin anabolism from tryptophan" EXACT []
synonym: "serotonin formation from tryptophan" EXACT []
synonym: "serotonin synthesis from tryptophan" EXACT []
is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0042427 ! serotonin biosynthetic process

[Term]
id: GO:0006588
name: activation of tryptophan 5-monooxygenase activity
namespace: biological_process
def: "The process by which the tryptophan 5-monooxygenase enzyme is changed so that it can carry out its enzymatic activity." [GOC:dph, GOC:tb]
synonym: "tryptophan hydroxylase activation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0032770 ! positive regulation of monooxygenase activity
relationship: part_of GO:0006587 ! serotonin biosynthetic process from tryptophan

[Term]
id: GO:0006589
name: octopamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepihephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "octopamine anabolism" EXACT []
synonym: "octopamine biosynthesis" EXACT []
synonym: "octopamine formation" EXACT []
synonym: "octopamine synthesis" EXACT []
is_a: GO:0042136 ! neurotransmitter biosynthetic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process
is_a: GO:0046189 ! phenol biosynthetic process
is_a: GO:0046333 ! octopamine metabolic process

[Term]
id: GO:0006590
name: thyroid hormone generation
namespace: biological_process
def: "The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones." [GOC:jl, ISBN:0716720094]
comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis.
is_a: GO:0042403 ! thyroid hormone metabolic process

[Term]
id: GO:0006591
name: ornithine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "ornithine metabolism" EXACT []
xref: Reactome:448571 "Ornithine metabolism"
xref: Reactome:469700 "Ornithine metabolism"
xref: Reactome:487627 "Ornithine metabolism"
xref: Reactome:507367 "Ornithine metabolism"
xref: Reactome:517562 "Ornithine metabolism"
xref: Reactome:526428 "Ornithine metabolism"
xref: Reactome:531245 "Ornithine metabolism"
xref: Reactome:536616 "Ornithine metabolism"
xref: Reactome:542341 "Ornithine metabolism"
xref: Reactome:547681 "Ornithine metabolism"
xref: Reactome:552268 "Ornithine metabolism"
xref: Reactome:557890 "Ornithine metabolism"
xref: Reactome:568488 "Ornithine metabolism"
xref: Reactome:581699 "Ornithine metabolism"
xref: Reactome:585842 "Ornithine metabolism"
xref: Reactome:592606 "Ornithine metabolism"
xref: Reactome:595414 "Ornithine metabolism"
xref: Reactome:597354 "Ornithine metabolism"
xref: Reactome:598151 "Ornithine metabolism"
xref: Reactome:599715 "Ornithine metabolism"
xref: Reactome:600619 "Ornithine metabolism"
xref: Reactome:602521 "Ornithine metabolism"
xref: Reactome:70693 "Ornithine metabolism"
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0006592
name: ornithine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "ornithine anabolism" EXACT []
synonym: "ornithine biosynthesis" EXACT []
synonym: "ornithine formation" EXACT []
synonym: "ornithine synthesis" EXACT []
is_a: GO:0006591 ! ornithine metabolic process
is_a: GO:0008652 ! cellular amino acid biosynthetic process

[Term]
id: GO:0006593
name: ornithine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "ornithine breakdown" EXACT []
synonym: "ornithine catabolism" EXACT []
synonym: "ornithine degradation" EXACT []
is_a: GO:0006591 ! ornithine metabolic process
is_a: GO:0009063 ! cellular amino acid catabolic process

[Term]
id: GO:0006595
name: polyamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "polyamine metabolism" EXACT []
xref: Reactome:351202 "Metabolism of polyamines"
xref: Reactome:448774 "Metabolism of polyamines"
xref: Reactome:469889 "Metabolism of polyamines"
xref: Reactome:487596 "Metabolism of polyamines"
xref: Reactome:507551 "Metabolism of polyamines"
xref: Reactome:517706 "Metabolism of polyamines"
xref: Reactome:526683 "Metabolism of polyamines"
xref: Reactome:531213 "Metabolism of polyamines"
xref: Reactome:536842 "Metabolism of polyamines"
xref: Reactome:542309 "Metabolism of polyamines"
xref: Reactome:547649 "Metabolism of polyamines"
xref: Reactome:552498 "Metabolism of polyamines"
xref: Reactome:558116 "Metabolism of polyamines"
xref: Reactome:568451 "Metabolism of polyamines"
xref: Reactome:581664 "Metabolism of polyamines"
xref: Reactome:585991 "Metabolism of polyamines"
xref: Reactome:592852 "Metabolism of polyamines"
xref: Reactome:595565 "Metabolism of polyamines"
xref: Reactome:597337 "Metabolism of polyamines"
xref: Reactome:598142 "Metabolism of polyamines"
xref: Reactome:599696 "Metabolism of polyamines"
xref: Reactome:600603 "Metabolism of polyamines"
xref: Reactome:602611 "Metabolism of polyamines"
is_a: GO:0006576 ! cellular biogenic amine metabolic process

[Term]
id: GO:0006596
name: polyamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "polyamine anabolism" EXACT []
synonym: "polyamine biosynthesis" EXACT []
synonym: "polyamine formation" EXACT []
synonym: "polyamine synthesis" EXACT []
xref: MetaCyc:POLYAMSYN-PWY
xref: Reactome:351200 "Interconversion of polyamines"
xref: Reactome:449201 "Interconversion of polyamines"
xref: Reactome:470322 "Interconversion of polyamines"
xref: Reactome:487999 "Interconversion of polyamines"
xref: Reactome:508048 "Interconversion of polyamines"
xref: Reactome:517901 "Interconversion of polyamines"
xref: Reactome:526727 "Interconversion of polyamines"
xref: Reactome:531499 "Interconversion of polyamines"
xref: Reactome:536890 "Interconversion of polyamines"
xref: Reactome:542638 "Interconversion of polyamines"
xref: Reactome:547955 "Interconversion of polyamines"
xref: Reactome:568777 "Interconversion of polyamines"
xref: Reactome:581980 "Interconversion of polyamines"
xref: Reactome:592888 "Interconversion of polyamines"
xref: Reactome:602617 "Interconversion of polyamines"
is_a: GO:0006595 ! polyamine metabolic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process

[Term]
id: GO:0006597
name: spermine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "spermine anabolism" EXACT []
synonym: "spermine biosynthesis" EXACT []
synonym: "spermine formation" EXACT []
synonym: "spermine synthesis" EXACT []
is_a: GO:0006596 ! polyamine biosynthetic process
is_a: GO:0008215 ! spermine metabolic process

[Term]
id: GO:0006598
name: polyamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "polyamine breakdown" EXACT []
synonym: "polyamine catabolism" EXACT []
synonym: "polyamine degradation" EXACT []
is_a: GO:0006595 ! polyamine metabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process

[Term]
id: GO:0006599
name: phosphagen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphagen metabolism" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process

[Term]
id: GO:0006600
name: creatine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "creatine metabolism" EXACT []
xref: Reactome:448816 "Creatine metabolism"
xref: Reactome:469932 "Creatine metabolism"
xref: Reactome:487635 "Creatine metabolism"
xref: Reactome:507594 "Creatine metabolism"
xref: Reactome:517687 "Creatine metabolism"
xref: Reactome:526524 "Creatine metabolism"
xref: Reactome:542340 "Creatine metabolism"
xref: Reactome:557952 "Creatine metabolism"
xref: Reactome:71288 "Creatine metabolism"
is_a: GO:0006599 ! phosphagen metabolic process
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0006601
name: creatine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle." [ChEBI:16919, GOC:mah, MetaCyc:GLYCGREAT-PWY, MetaCyc:PWY-6158]
subset: gosubset_prok
synonym: "creatine anabolism" EXACT []
synonym: "creatine biosynthesis" EXACT []
synonym: "creatine formation" EXACT []
synonym: "creatine synthesis" EXACT []
is_a: GO:0006600 ! creatine metabolic process
is_a: GO:0042396 ! phosphagen biosynthetic process

[Term]
id: GO:0006602
name: creatinine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "creatinine breakdown" EXACT []
synonym: "creatinine catabolism" EXACT []
synonym: "creatinine degradation" EXACT []
is_a: GO:0042397 ! phosphagen catabolic process
is_a: GO:0043605 ! cellular amide catabolic process
is_a: GO:0046449 ! creatinine metabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0006603
name: phosphocreatine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "phosphocreatine metabolism" EXACT []
is_a: GO:0006599 ! phosphagen metabolic process

[Term]
id: GO:0006604
name: phosphoarginine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphoarginine, a phosphagen of L-arginine with phosphoric acid containing the phosphoamide bond. It is a source of energy in the contraction of muscle in invertebrates, corresponding to phosphocreatine in the muscles of vertebrates." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "phosphoarginine metabolism" EXACT []
is_a: GO:0006599 ! phosphagen metabolic process

[Term]
id: GO:0006605
name: protein targeting
namespace: biological_process
def: "The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma]
subset: goslim_pombe
subset: gosubset_prok
synonym: "nascent polypeptide association" RELATED []
synonym: "protein sorting along secretory pathway" NARROW []
xref: Wikipedia:Protein_targeting
is_a: GO:0006886 ! intracellular protein transport

[Term]
id: GO:0006606
name: protein import into nucleus
namespace: biological_process
def: "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl]
synonym: "protein import into cell nucleus" EXACT []
synonym: "protein nucleus import" EXACT []
synonym: "protein targeting to nucleus" EXACT [GOC:mah]
synonym: "protein transport from cytoplasm to nucleus" EXACT []
xref: Reactome:170796 "GK:GKRP [cytosol] => GK:GKRP [nucleoplasm]"
xref: Reactome:439842 "GK:GKRP [cytosol] => GK:GKRP [nucleoplasm]"
xref: Reactome:500461 "GK:GKRP [cytosol] => GK:GKRP [nucleoplasm]"
is_a: GO:0006605 ! protein targeting
is_a: GO:0017038 ! protein import
is_a: GO:0051170 ! nuclear import
relationship: part_of GO:0034504 ! protein localization in nucleus

[Term]
id: GO:0006607
name: NLS-bearing substrate import into nucleus
namespace: biological_process
def: "The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai]
synonym: "NLS-bearing substrate import into cell nucleus" EXACT []
synonym: "NLS-bearing substrate transport from cytoplasm to nucleus" EXACT []
synonym: "NLS-bearing substrate-nucleus import" EXACT []
is_a: GO:0006606 ! protein import into nucleus

[Term]
id: GO:0006608
name: snRNP protein import into nucleus
namespace: biological_process
def: "The directed movement of a small nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai]
synonym: "snRNP protein import into cell nucleus" EXACT []
synonym: "snRNP protein transport from cytoplasm to nucleus" EXACT []
synonym: "snRNP protein-nucleus import" EXACT []
is_a: GO:0006606 ! protein import into nucleus

[Term]
id: GO:0006609
name: mRNA-binding (hnRNP) protein import into nucleus
namespace: biological_process
def: "The directed movement of a heterogeneous nuclear ribonucleoprotein complex from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah]
synonym: "mRNA-binding (hnRNP) protein import into cell nucleus" EXACT []
synonym: "mRNA-binding (hnRNP) protein transport from cytoplasm to nucleus" EXACT []
synonym: "mRNA-binding (hnRNP) protein-nucleus import" EXACT []
is_a: GO:0006606 ! protein import into nucleus

[Term]
id: GO:0006610
name: ribosomal protein import into nucleus
namespace: biological_process
def: "The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai]
synonym: "ribosomal protein import into cell nucleus" EXACT []
synonym: "ribosomal protein transport from cytoplasm to nucleus" EXACT []
synonym: "ribosomal protein-nucleus import" EXACT []
is_a: GO:0006606 ! protein import into nucleus

[Term]
id: GO:0006611
name: protein export from nucleus
namespace: biological_process
def: "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl]
synonym: "protein export from cell nucleus" EXACT []
synonym: "protein export out of nucleus" EXACT []
synonym: "protein transport from nucleus to cytoplasm" EXACT []
synonym: "protein-nucleus export" EXACT []
xref: Reactome:170825 "glucokinase [nucleoplasm] => glucokinase [cytosol]"
xref: Reactome:439883 "glucokinase [nucleoplasm] => glucokinase [cytosol]"
xref: Reactome:461655 "glucokinase [nucleoplasm] => glucokinase [cytosol]"
xref: Reactome:480463 "glucokinase [nucleoplasm] => glucokinase [cytosol]"
xref: Reactome:500493 "glucokinase [nucleoplasm] => glucokinase [cytosol]"
xref: Reactome:513986 "glucokinase [nucleoplasm] => glucokinase [cytosol]"
is_a: GO:0006605 ! protein targeting
is_a: GO:0051168 ! nuclear export

[Term]
id: GO:0006612
name: protein targeting to membrane
namespace: biological_process
def: "The process of directing proteins towards a membrane, usually using signals contained within the protein." [http://cancerweb.ncl.ac.uk/]
synonym: "protein membrane targeting" EXACT []
synonym: "protein-membrane targeting" EXACT []
is_a: GO:0006605 ! protein targeting

[Term]
id: GO:0006613
name: cotranslational protein targeting to membrane
namespace: biological_process
def: "The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria." [ISBN:0716731363, PMID:10512867, PMID:16896215]
synonym: "cotranslational membrane targeting" EXACT []
synonym: "cotranslational protein membrane targeting" EXACT []
synonym: "cotranslational protein-membrane targeting" EXACT []
is_a: GO:0006612 ! protein targeting to membrane

[Term]
id: GO:0006614
name: SRP-dependent cotranslational protein targeting to membrane
namespace: biological_process
def: "The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363]
synonym: "ER translocation" BROAD []
synonym: "SRP-dependent cotranslational membrane targeting" EXACT []
synonym: "SRP-dependent cotranslational protein-membrane targeting" EXACT []
is_a: GO:0006613 ! cotranslational protein targeting to membrane
is_a: GO:0045047 ! protein targeting to ER

[Term]
id: GO:0006615
name: SRP-dependent cotranslational protein targeting to membrane, docking
namespace: biological_process
def: "The process by which an SRP-bound ribosome forms a complex with the SRP receptor in the ER membrane, allowing the ribosome to bind to the membrane, during cotranslational membrane targeting." [ISBN:0815316194]
synonym: "protein docking during SRP-dependent cotranslational protein targeting to membrane" EXACT []
synonym: "SRP-dependent cotranslational membrane targeting, docking" EXACT []
synonym: "SRP-dependent cotranslational protein-membrane targeting, docking" EXACT []
is_a: GO:0022615 ! protein to membrane docking
relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane

[Term]
id: GO:0006616
name: SRP-dependent cotranslational protein targeting to membrane, translocation
namespace: biological_process
def: "The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen." [ISBN:0716731363]
synonym: "ER translocation" BROAD []
synonym: "SRP-dependent cotranslational membrane targeting, translocation" EXACT []
synonym: "SRP-dependent cotranslational protein-membrane targeting, translocation" EXACT []
synonym: "translocation during SRP-dependent cotranslational protein targeting to membrane" EXACT []
is_a: GO:0065002 ! intracellular protein transmembrane transport
relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane

[Term]
id: GO:0006617
name: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
namespace: biological_process
def: "The process by which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting." [ISBN:0815316194]
synonym: "signal sequence recognition during SRP-dependent cotranslational protein targeting to membrane" EXACT []
synonym: "SRP-dependent cotranslational membrane targeting, signal sequence recognition" EXACT []
synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence recognition" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane

[Term]
id: GO:0006618
name: SRP-dependent cotranslational protein targeting to membrane, signal sequence processing
namespace: biological_process
def: "The removal of the signal peptide from a nascent protein during cotranslational membrane targeting." [ISBN:0815316194]
synonym: "signal sequence processing during SRP-dependent cotranslational protein targeting to membrane" EXACT []
synonym: "SRP-dependent cotranslational membrane targeting, signal sequence processing" EXACT []
synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence processing" EXACT []
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process
relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane

[Term]
id: GO:0006619
name: SRP-independent cotranslational protein-membrane targeting
namespace: biological_process
def: "OBSOLETE. The targeting of proteins to a membrane that occurs during translation and is independent of SRP and signal recognition." [GOC:ai, PMID:11101515]
comment: This term was made obsolete because there is no evidence for the existence of this process.
synonym: "ER translocation" BROAD []
synonym: "SRP-independent cotranslational membrane targeting" EXACT []
is_obsolete: true

[Term]
id: GO:0006620
name: posttranslational protein targeting to membrane
namespace: biological_process
def: "The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane." [ISBN:0716731363]
synonym: "posttranslational membrane targeting" EXACT []
synonym: "posttranslational protein membrane targeting" EXACT []
synonym: "posttranslational protein-membrane targeting" EXACT []
synonym: "SRP-independent protein-membrane targeting" EXACT []
is_a: GO:0006612 ! protein targeting to membrane
is_a: GO:0045047 ! protein targeting to ER

[Term]
id: GO:0006621
name: protein retention in ER lumen
namespace: biological_process
def: "The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550]
synonym: "maintenance of protein location in ER lumen" BROAD [GOC:dph, GOC:tb]
synonym: "protein-endoplasmic reticulum retention" EXACT []
synonym: "protein-ER retention" EXACT []
synonym: "retention of protein in endoplasmic reticulum" EXACT []
synonym: "retention of protein in ER" EXACT []
is_a: GO:0032507 ! maintenance of protein location in cell

[Term]
id: GO:0006622
name: protein targeting to lysosome
namespace: biological_process
def: "The process of directing proteins towards the lysosome using signals contained within the protein." [http://cancerweb.ncl.ac.uk/]
synonym: "protein-lysosome targeting" EXACT []
is_a: GO:0006623 ! protein targeting to vacuole
is_a: GO:0007041 ! lysosomal transport

[Term]
id: GO:0006623
name: protein targeting to vacuole
namespace: biological_process
def: "The process of directing proteins towards the vacuole, usually using signals contained within the protein." [http://cancerweb.ncl.ac.uk/]
synonym: "protein vacuolar targeting" EXACT []
synonym: "protein-vacuolar targeting" EXACT []
synonym: "protein-vacuole targeting" EXACT []
synonym: "vacuolar protein sorting" EXACT [GOC:vw]
is_a: GO:0006605 ! protein targeting
is_a: GO:0007034 ! vacuolar transport

[Term]
id: GO:0006624
name: vacuolar protein processing
namespace: biological_process
def: "The posttranslational modification of proteins in the vacuole, including proteolytic cleavage of precursors to form active enzymes." [GOC:mah]
synonym: "vacuolar protein maturation" EXACT []
synonym: "vacuolar proteolysis" EXACT []
is_a: GO:0016485 ! protein processing

[Term]
id: GO:0006625
name: protein targeting to peroxisome
namespace: biological_process
def: "The process of directing proteins towards the peroxisome, usually using signals contained within the protein." [GOC:ai]
synonym: "protein-peroxisome targeting" EXACT []
is_a: GO:0006605 ! protein targeting
is_a: GO:0043574 ! peroxisomal transport
relationship: part_of GO:0007031 ! peroxisome organization

[Term]
id: GO:0006626
name: protein targeting to mitochondrion
namespace: biological_process
alt_id: GO:0043681
def: "The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363]
synonym: "mitochondrial protein import" RELATED []
synonym: "mitochondrial translocation" RELATED []
synonym: "protein import into mitochondrion" EXACT []
synonym: "protein targeting to mitochondria" EXACT []
synonym: "protein-mitochondrial targeting" EXACT []
is_a: GO:0006605 ! protein targeting
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0017038 ! protein import
relationship: part_of GO:0007005 ! mitochondrion organization
relationship: part_of GO:0070585 ! protein localization in mitochondrion

[Term]
id: GO:0006627
name: mitochondrial protein processing during import
namespace: biological_process
def: "The cleavage of peptide bonds in proteins, usually near the N terminus, during the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments." [GOC:mcc, PMID:12191769]
synonym: "mitochondrial processing" BROAD []
is_a: GO:0034982 ! mitochondrial protein processing
relationship: part_of GO:0006626 ! protein targeting to mitochondrion

[Term]
id: GO:0006628
name: mitochondrial translocation
namespace: biological_process
def: "OBSOLETE. The translocation of proteins across the mitochondrial membrane. In the presence of a translocating chain, the outer membrane import machinery (MOM complex) and the inner membrane import machinery (MIM complex) form translocation contact sites as a part of the membrane preprotein import machinery." [PMID:7600576]
comment: This term was made obsolete because its definition was equivalent to that of the biological process term 'mitochondrial matrix protein import ; GO:0030150' while the mitochondrial translocation has a broader meaning; this led to mis-annotation.
is_obsolete: true
consider: GO:0006626

[Term]
id: GO:0006629
name: lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: gosubset_prok
synonym: "lipid metabolism" EXACT []
xref: Reactome:448458 "Metabolism of lipids and lipoproteins"
xref: Reactome:469588 "Metabolism of lipids and lipoproteins"
xref: Reactome:487307 "Metabolism of lipids and lipoproteins"
xref: Reactome:507258 "Metabolism of lipids and lipoproteins"
xref: Reactome:517280 "Metabolism of lipids and lipoproteins"
xref: Reactome:526158 "Metabolism of lipids and lipoproteins"
xref: Reactome:531055 "Metabolism of lipids and lipoproteins"
xref: Reactome:536437 "Metabolism of lipids and lipoproteins"
xref: Reactome:542134 "Metabolism of lipids and lipoproteins"
xref: Reactome:547525 "Metabolism of lipids and lipoproteins"
xref: Reactome:552094 "Metabolism of lipids and lipoproteins"
xref: Reactome:557672 "Metabolism of lipids and lipoproteins"
xref: Reactome:568290 "Metabolism of lipids and lipoproteins"
xref: Reactome:581492 "Metabolism of lipids and lipoproteins"
xref: Reactome:585774 "Metabolism of lipids and lipoproteins"
xref: Reactome:592389 "Metabolism of lipids and lipoproteins"
xref: Reactome:595297 "Metabolism of lipids and lipoproteins"
xref: Reactome:597258 "Metabolism of lipids and lipoproteins"
xref: Reactome:598099 "Metabolism of lipids and lipoproteins"
xref: Reactome:599584 "Metabolism of lipids and lipoproteins"
xref: Reactome:600579 "Metabolism of lipids and lipoproteins"
xref: Reactome:602390 "Metabolism of lipids and lipoproteins"
xref: Reactome:73923 "Metabolism of lipids and lipoproteins"
xref: Wikipedia:Lipid_metabolism
is_a: GO:0044238 ! primary metabolic process

[Term]
id: GO:0006630
name: lipid binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
is_obsolete: true
consider: GO:0008289

[Term]
id: GO:0006631
name: fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684]
subset: gosubset_prok
synonym: "fatty acid metabolism" EXACT []
xref: Reactome:435828 "CYP4A11 omega-hydroxylates laurate"
xref: Reactome:458217 "CYP4A11 omega-hydroxylates laurate"
xref: Reactome:477703 "CYP4A11 omega-hydroxylates laurate"
xref: Reactome:497235 "CYP4A11 omega-hydroxylates laurate"
xref: Reactome:512469 "CYP4A11 omega-hydroxylates laurate"
xref: Reactome:521604 "CYP4A11 omega-hydroxylates laurate"
xref: Reactome:528801 "CYP4A11 omega-hydroxylates laurate"
xref: Reactome:533950 "CYP4A11 omega-hydroxylates laurate"
xref: Reactome:539444 "CYP4A11 omega-hydroxylates laurate"
xref: Reactome:549898 "CYP4A11 omega-hydroxylates laurate"
xref: Reactome:555052 "CYP4A11 omega-hydroxylates laurate"
xref: Reactome:563679 "CYP4A11 omega-hydroxylates laurate"
xref: Reactome:575739 "CYP4A11 omega-hydroxylates laurate"
xref: Reactome:589183 "CYP4A11 omega-hydroxylates laurate"
xref: Reactome:601486 "CYP4A11 omega-hydroxylates laurate"
xref: Reactome:76466 "CYP4A11 omega-hydroxylates laurate"
xref: Wikipedia:Fatty_acid_metabolism
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0006633
name: fatty acid biosynthetic process
namespace: biological_process
alt_id: GO:0000037
def: "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "fatty acid anabolism" EXACT []
synonym: "fatty acid biosynthesis" EXACT []
synonym: "fatty acid formation" EXACT []
synonym: "fatty acid synthesis" EXACT []
xref: MetaCyc:FASYN-INITIAL-PWY
xref: MetaCyc:PWY-4381
xref: MetaCyc:PWY-5156
xref: Wikipedia:Fatty_acid_synthesis
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0006634
name: hexadecanal biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hexadecanal, the C16 straight chain aldehyde." [http://chemfinder.cambridgesoft.com/]
subset: gosubset_prok
synonym: "hexadecanal anabolism" EXACT []
synonym: "hexadecanal biosynthesis" EXACT []
synonym: "hexadecanal formation" EXACT []
synonym: "hexadecanal synthesis" EXACT []
synonym: "palmitaldehyde biosynthesis" EXACT []
synonym: "palmitaldehyde biosynthetic process" EXACT []
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0046458 ! hexadecanal metabolic process

[Term]
id: GO:0006635
name: fatty acid beta-oxidation
namespace: biological_process
def: "A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:FAO-PWY]
subset: gosubset_prok
xref: Reactome:109339 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA"
xref: Reactome:109341 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA"
xref: Reactome:109342 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA"
xref: Reactome:109343 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA"
xref: Reactome:109998 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA"
xref: Reactome:436286 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA"
xref: Reactome:441289 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA"
xref: Reactome:446170 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA"
xref: Reactome:446482 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA"
xref: Reactome:446497 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA"
xref: Reactome:448473 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:449023 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"
xref: Reactome:458696 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA"
xref: Reactome:463096 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA"
xref: Reactome:467491 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA"
xref: Reactome:467805 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA"
xref: Reactome:467820 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA"
xref: Reactome:469603 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:470136 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"
xref: Reactome:481771 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA"
xref: Reactome:485470 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA"
xref: Reactome:485715 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA"
xref: Reactome:485723 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA"
xref: Reactome:487322 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:487956 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"
xref: Reactome:497679 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA"
xref: Reactome:501985 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA"
xref: Reactome:505259 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA"
xref: Reactome:505602 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA"
xref: Reactome:505615 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA"
xref: Reactome:507273 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:507796 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"
xref: Reactome:512823 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA"
xref: Reactome:514649 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA"
xref: Reactome:517294 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:517715 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"
xref: Reactome:521990 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA"
xref: Reactome:525186 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA"
xref: Reactome:526172 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:526554 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"
xref: Reactome:528937 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA"
xref: Reactome:530520 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA"
xref: Reactome:531064 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:531346 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"
xref: Reactome:535926 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA"
xref: Reactome:536871 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"
xref: Reactome:536872 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:541536 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA"
xref: Reactome:542141 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:542626 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"
xref: Reactome:552097 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:556244 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA"
xref: Reactome:557075 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA"
xref: Reactome:557679 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:558075 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"
xref: Reactome:567137 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA"
xref: Reactome:568299 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:568768 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"
xref: Reactome:580151 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA"
xref: Reactome:581501 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:581971 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"
xref: Reactome:592398 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:596542 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA"
xref: Reactome:597257 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:597397 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"
xref: Reactome:599583 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:601555 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA"
xref: Reactome:602216 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA"
xref: Reactome:602217 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA"
xref: Reactome:602395 "Mitochondrial Fatty Acid Beta-Oxidation"
xref: Reactome:602553 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"
xref: Reactome:77288 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids"
xref: Reactome:77289 "Mitochondrial Fatty Acid Beta-Oxidation"
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0006636
name: unsaturated fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah, MetaCyc:PWY-762, MetaCyc:PWY-782]
subset: gosubset_prok
synonym: "fatty acid desaturation" RELATED []
synonym: "unsaturated fatty acid anabolism" EXACT []
synonym: "unsaturated fatty acid biosynthesis" EXACT []
synonym: "unsaturated fatty acid formation" EXACT []
synonym: "unsaturated fatty acid synthesis" EXACT []
xref: MetaCyc:PWY-762
xref: MetaCyc:PWY-782
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process

[Term]
id: GO:0006637
name: acyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "acyl-CoA metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0006732 ! coenzyme metabolic process

[Term]
id: GO:0006638
name: neutral lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity." [ISBN:0198547684]
subset: gosubset_prok
synonym: "neutral lipid metabolism" EXACT []
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0006639
name: acylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "acylglycerol metabolism" EXACT []
synonym: "glyceride metabolic process" EXACT []
synonym: "glyceride metabolism" EXACT []
is_a: GO:0006638 ! neutral lipid metabolic process
is_a: GO:0006662 ! glycerol ether metabolic process
is_a: GO:0046486 ! glycerolipid metabolic process

[Term]
id: GO:0006640
name: monoacylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "monoacylglycerol anabolism" EXACT []
synonym: "monoacylglycerol biosynthesis" EXACT []
synonym: "monoacylglycerol formation" EXACT []
synonym: "monoacylglycerol synthesis" EXACT []
synonym: "monoglyceride biosynthesis" EXACT []
synonym: "monoglyceride biosynthetic process" EXACT []
is_a: GO:0046462 ! monoacylglycerol metabolic process
is_a: GO:0046463 ! acylglycerol biosynthetic process

[Term]
id: GO:0006641
name: triglyceride metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "triacylglycerol metabolic process" EXACT []
synonym: "triacylglycerol metabolism" EXACT []
synonym: "triglyceride metabolism" EXACT []
is_a: GO:0006639 ! acylglycerol metabolic process

[Term]
id: GO:0006642
name: triglyceride mobilization
namespace: biological_process
def: "The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism." [GOC:mah, PMID:11943743, PMID:15713625]
subset: gosubset_prok
synonym: "triacylglycerol mobilization" EXACT []
is_a: GO:0006641 ! triglyceride metabolic process

[Term]
id: GO:0006643
name: membrane lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai]
subset: gosubset_prok
synonym: "membrane lipid metabolism" EXACT []
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0006644
name: phospholipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phospholipid metabolism" EXACT []
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0006646
name: phosphatidylethanolamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphatidylethanolamine anabolism" EXACT []
synonym: "phosphatidylethanolamine biosynthesis" EXACT []
synonym: "phosphatidylethanolamine formation" EXACT []
synonym: "phosphatidylethanolamine synthesis" EXACT []
is_a: GO:0046335 ! ethanolamine biosynthetic process
is_a: GO:0046337 ! phosphatidylethanolamine metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0006647
name: phosphatidyl-N-monomethylethanolamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group." [GOC:ai]
subset: gosubset_prok
synonym: "phosphatidyl-N-monomethylethanolamine anabolism" EXACT []
synonym: "phosphatidyl-N-monomethylethanolamine biosynthesis" EXACT []
synonym: "phosphatidyl-N-monomethylethanolamine formation" EXACT []
synonym: "phosphatidyl-N-monomethylethanolamine synthesis" EXACT []
synonym: "PMME biosynthesis" EXACT []
synonym: "PMME biosynthetic process" EXACT []
is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process
is_a: GO:0046468 ! phosphatidyl-N-monomethylethanolamine metabolic process

[Term]
id: GO:0006648
name: dihydrosphingosine-1-P pathway
namespace: biological_process
subset: gosubset_prok
is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process

[Term]
id: GO:0006649
name: phospholipid transfer to membrane
namespace: biological_process
def: "The transfer of a phospholipid from its site of synthesis to the plasma membrane." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0015914 ! phospholipid transport

[Term]
id: GO:0006650
name: glycerophospholipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycerophospholipid metabolism" EXACT []
synonym: "phosphoglyceride metabolic process" EXACT []
synonym: "phosphoglyceride metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0046486 ! glycerolipid metabolic process

[Term]
id: GO:0006651
name: diacylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "diacylglycerol anabolism" EXACT []
synonym: "diacylglycerol biosynthesis" EXACT []
synonym: "diacylglycerol formation" EXACT []
synonym: "diacylglycerol synthesis" EXACT []
is_a: GO:0046339 ! diacylglycerol metabolic process
is_a: GO:0046463 ! acylglycerol biosynthetic process

[Term]
id: GO:0006652
name: alpha-glycerophosphate pathway
namespace: biological_process
subset: gosubset_prok
is_a: GO:0006650 ! glycerophospholipid metabolic process

[Term]
id: GO:0006653
name: lecithin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lecithin, any 3-sn-phosphatidylcholine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "lecithin metabolism" EXACT []
is_a: GO:0046470 ! phosphatidylcholine metabolic process

[Term]
id: GO:0006654
name: phosphatidic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphatidic acid anabolism" EXACT []
synonym: "phosphatidic acid biosynthesis" EXACT []
synonym: "phosphatidic acid formation" EXACT []
synonym: "phosphatidic acid synthesis" EXACT []
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0046473 ! phosphatidic acid metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0006655
name: phosphatidylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphatidylglycerol anabolism" EXACT []
synonym: "phosphatidylglycerol biosynthesis" EXACT []
synonym: "phosphatidylglycerol formation" EXACT []
synonym: "phosphatidylglycerol synthesis" EXACT []
is_a: GO:0046471 ! phosphatidylglycerol metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0006656
name: phosphatidylcholine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphatidylcholine anabolism" EXACT []
synonym: "phosphatidylcholine biosynthesis" EXACT []
synonym: "phosphatidylcholine formation" EXACT []
synonym: "phosphatidylcholine synthesis" EXACT []
is_a: GO:0046470 ! phosphatidylcholine metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0006657
name: CDP-choline pathway
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine." [ISBN:0471331309 "Biochemical Pathways", MetaCyc:PWY3O-450]
subset: gosubset_prok
synonym: "Kennedy pathway" EXACT [MetaCyc:PWY3O-450]
synonym: "phosphatidylcholine biosynthesis from choline" EXACT [GOC:mah, MetaCyc:PWY3O-450]
xref: MetaCyc:PWY3O-450
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process

[Term]
id: GO:0006658
name: phosphatidylserine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphatidylserine metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process

[Term]
id: GO:0006659
name: phosphatidylserine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphatidylserine anabolism" EXACT []
synonym: "phosphatidylserine biosynthesis" EXACT []
synonym: "phosphatidylserine formation" EXACT []
synonym: "phosphatidylserine synthesis" EXACT []
is_a: GO:0006658 ! phosphatidylserine metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0006660
name: phosphatidylserine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphatidylserine breakdown" EXACT []
synonym: "phosphatidylserine catabolism" EXACT []
synonym: "phosphatidylserine degradation" EXACT []
is_a: GO:0006658 ! phosphatidylserine metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process

[Term]
id: GO:0006661
name: phosphatidylinositol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphatidylinositol anabolism" EXACT []
synonym: "phosphatidylinositol biosynthesis" EXACT []
synonym: "phosphatidylinositol formation" EXACT []
synonym: "phosphatidylinositol synthesis" EXACT []
synonym: "PtdIns biosynthesis" EXACT []
synonym: "PtdIns biosynthetic process" EXACT []
is_a: GO:0046488 ! phosphatidylinositol metabolic process
is_a: GO:0046489 ! phosphoinositide biosynthetic process

[Term]
id: GO:0006662
name: glycerol ether metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
synonym: "glycerol ether metabolism" EXACT []
is_a: GO:0018904 ! organic ether metabolic process

[Term]
id: GO:0006663
name: platelet activating factor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli." [ISBN:0198547684]
synonym: "PAF biosynthesis" EXACT []
synonym: "PAF biosynthetic process" EXACT []
synonym: "platelet activating factor anabolism" EXACT []
synonym: "platelet activating factor biosynthesis" EXACT []
synonym: "platelet activating factor formation" EXACT []
synonym: "platelet activating factor synthesis" EXACT []
is_a: GO:0046469 ! platelet activating factor metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0006664
name: glycolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid." [ISBN:0198547684]
subset: gosubset_prok
synonym: "glycolipid metabolism" EXACT []
is_a: GO:0006643 ! membrane lipid metabolic process

[Term]
id: GO:0006665
name: sphingolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sphingolipid metabolism" EXACT []
is_a: GO:0006643 ! membrane lipid metabolic process

[Term]
id: GO:0006666
name: 3-keto-sphinganine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine." [GOC:ai]
subset: gosubset_prok
synonym: "3-keto-dihydrosphingosine metabolic process" EXACT []
synonym: "3-keto-dihydrosphingosine metabolism" EXACT []
synonym: "3-keto-sphinganine metabolism" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0046519 ! sphingoid metabolic process

[Term]
id: GO:0006667
name: sphinganine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol." [http://www.chem.qmul.ac.uk/iupac/lipid/lip1n2.html#p18]
subset: gosubset_prok
synonym: "dihydrosphingosine metabolic process" EXACT []
synonym: "dihydrosphingosine metabolism" EXACT []
synonym: "sphinganine metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0046519 ! sphingoid metabolic process

[Term]
id: GO:0006668
name: sphinganine-1-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai]
subset: gosubset_prok
synonym: "dihydrosphingosine-1-phosphate metabolic process" EXACT []
synonym: "dihydrosphingosine-1-phosphate metabolism" EXACT []
synonym: "sphinganine-1-phosphate metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006667 ! sphinganine metabolic process

[Term]
id: GO:0006669
name: sphinganine-1-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai]
subset: gosubset_prok
synonym: "dihydrosphingosine-1-phosphate biosynthesis" EXACT []
synonym: "dihydrosphingosine-1-phosphate biosynthetic process" EXACT []
synonym: "sphinganine-1-phosphate anabolism" EXACT []
synonym: "sphinganine-1-phosphate biosynthesis" EXACT []
synonym: "sphinganine-1-phosphate formation" EXACT []
synonym: "sphinganine-1-phosphate synthesis" EXACT []
is_a: GO:0006668 ! sphinganine-1-phosphate metabolic process
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0046511 ! sphinganine biosynthetic process

[Term]
id: GO:0006670
name: sphingosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "(4E)-sphing-4-enine metabolic process" EXACT []
synonym: "(4E)-sphing-4-enine metabolism" EXACT []
synonym: "sphing-4-enine metabolic process" EXACT []
synonym: "sphing-4-enine metabolism" EXACT []
synonym: "sphingosine metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0046519 ! sphingoid metabolic process

[Term]
id: GO:0006671
name: phytosphingosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol, a constituent of many plant sphingolipids." [ChEBI:46961, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phytosphingosine metabolism" EXACT []
is_a: GO:0046519 ! sphingoid metabolic process

[Term]
id: GO:0006672
name: ceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." [ISBN:0198547684]
subset: gosubset_prok
synonym: "ceramide metabolism" EXACT []
is_a: GO:0046519 ! sphingoid metabolic process

[Term]
id: GO:0006673
name: inositolphosphoceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving inositolphosphoceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide moiety." [http://www.chem.qmul.ac.uk/iupac/misc/glylp.html]
subset: gosubset_prok
synonym: "inositolphosphoceramide metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006672 ! ceramide metabolic process

[Term]
id: GO:0006674
name: inositol phosphorylceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving inositol phosphorylceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide moiety. The phosphate-containing moiety is the trivalent -P(O)= and the ceramide moiety of this lipid consists of phytosphingosine and a hydroxy C26 fatty acid." [http://www.cyberlipid.org/]
subset: gosubset_prok
synonym: "inositol phosphorylceramide metabolism" EXACT []
is_a: GO:0006673 ! inositolphosphoceramide metabolic process

[Term]
id: GO:0006675
name: mannose inositol phosphoceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannose inositol phosphoceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide moiety which contains a phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai]
subset: gosubset_prok
synonym: "mannose inositol phosphoceramide metabolism" EXACT []
synonym: "mannose-inositol-P-ceramide (MIPC) metabolic process" EXACT []
synonym: "mannose-inositol-P-ceramide (MIPC) metabolism" EXACT []
synonym: "MIPC metabolic process" EXACT []
synonym: "MIPC metabolism" EXACT []
is_a: GO:0006673 ! inositolphosphoceramide metabolic process

[Term]
id: GO:0006676
name: mannosyl diphosphorylinositol ceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannosyl diphosphorylinositol ceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide moiety which contains two phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai]
subset: gosubset_prok
synonym: "M(IP)2C metabolic process" EXACT []
synonym: "M(IP)2C metabolism" EXACT []
synonym: "mannosyl diphosphorylinositol ceramide metabolism" EXACT []
is_a: GO:0006673 ! inositolphosphoceramide metabolic process

[Term]
id: GO:0006677
name: glycosylceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycosylceramide metabolism" EXACT []
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0006672 ! ceramide metabolic process

[Term]
id: GO:0006678
name: glucosylceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glucosylceramide metabolism" EXACT []
is_a: GO:0006677 ! glycosylceramide metabolic process
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0006679
name: glucosylceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai]
subset: gosubset_prok
synonym: "glucosylceramide anabolism" EXACT []
synonym: "glucosylceramide biosynthesis" EXACT []
synonym: "glucosylceramide formation" EXACT []
synonym: "glucosylceramide synthesis" EXACT []
is_a: GO:0006678 ! glucosylceramide metabolic process
is_a: GO:0006688 ! glycosphingolipid biosynthetic process
is_a: GO:0046476 ! glycosylceramide biosynthetic process

[Term]
id: GO:0006680
name: glucosylceramide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai]
subset: gosubset_prok
synonym: "glucosylceramide breakdown" EXACT []
synonym: "glucosylceramide catabolism" EXACT []
synonym: "glucosylceramide degradation" EXACT []
is_a: GO:0006678 ! glucosylceramide metabolic process
is_a: GO:0046477 ! glycosylceramide catabolic process
is_a: GO:0046479 ! glycosphingolipid catabolic process

[Term]
id: GO:0006681
name: galactosylceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai]
subset: gosubset_prok
synonym: "galactosylceramide metabolism" EXACT []
is_a: GO:0006677 ! glycosylceramide metabolic process
is_a: GO:0006687 ! glycosphingolipid metabolic process
is_a: GO:0019374 ! galactolipid metabolic process

[Term]
id: GO:0006682
name: galactosylceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai]
subset: gosubset_prok
synonym: "galactosylceramide anabolism" EXACT []
synonym: "galactosylceramide biosynthesis" EXACT []
synonym: "galactosylceramide formation" EXACT []
synonym: "galactosylceramide synthesis" EXACT []
is_a: GO:0006681 ! galactosylceramide metabolic process
is_a: GO:0006688 ! glycosphingolipid biosynthetic process
is_a: GO:0019375 ! galactolipid biosynthetic process
is_a: GO:0046476 ! glycosylceramide biosynthetic process

[Term]
id: GO:0006683
name: galactosylceramide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai]
subset: gosubset_prok
synonym: "galactosylceramide breakdown" EXACT []
synonym: "galactosylceramide catabolism" EXACT []
synonym: "galactosylceramide degradation" EXACT []
is_a: GO:0006681 ! galactosylceramide metabolic process
is_a: GO:0019376 ! galactolipid catabolic process
is_a: GO:0046477 ! glycosylceramide catabolic process
is_a: GO:0046479 ! glycosphingolipid catabolic process

[Term]
id: GO:0006684
name: sphingomyelin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sphingomyelin metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006665 ! sphingolipid metabolic process

[Term]
id: GO:0006685
name: sphingomyelin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sphingomyelin breakdown" EXACT []
synonym: "sphingomyelin catabolism" EXACT []
synonym: "sphingomyelin degradation" EXACT []
is_a: GO:0006684 ! sphingomyelin metabolic process
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0030149 ! sphingolipid catabolic process

[Term]
id: GO:0006686
name: sphingomyelin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sphingomyelin anabolism" EXACT []
synonym: "sphingomyelin biosynthesis" EXACT []
synonym: "sphingomyelin formation" EXACT []
synonym: "sphingomyelin synthesis" EXACT []
is_a: GO:0006684 ! sphingomyelin metabolic process
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0046513 ! ceramide biosynthetic process

[Term]
id: GO:0006687
name: glycosphingolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684]
subset: gosubset_prok
synonym: "glycosphingolipid metabolism" EXACT []
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0006665 ! sphingolipid metabolic process

[Term]
id: GO:0006688
name: glycosphingolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycosphingolipid anabolism" EXACT []
synonym: "glycosphingolipid biosynthesis" EXACT []
synonym: "glycosphingolipid formation" EXACT []
synonym: "glycosphingolipid synthesis" EXACT []
is_a: GO:0006687 ! glycosphingolipid metabolic process
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0030148 ! sphingolipid biosynthetic process

[Term]
id: GO:0006689
name: ganglioside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues." [ISBN:0198547684]
subset: gosubset_prok
synonym: "ganglioside breakdown" EXACT []
synonym: "ganglioside catabolism" EXACT []
synonym: "ganglioside degradation" EXACT []
is_a: GO:0001573 ! ganglioside metabolic process
is_a: GO:0046479 ! glycosphingolipid catabolic process

[Term]
id: GO:0006690
name: icosanoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids." [GOC:ma]
subset: gosubset_prok
synonym: "eicosanoid metabolic process" EXACT []
synonym: "eicosanoid metabolism" EXACT []
synonym: "icosanoid metabolism" EXACT []
is_a: GO:0033559 ! unsaturated fatty acid metabolic process

[Term]
id: GO:0006691
name: leukotriene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:ma]
subset: gosubset_prok
synonym: "leukotriene metabolism" EXACT []
is_a: GO:0006690 ! icosanoid metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0006692
name: prostanoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "prostanoid metabolism" EXACT []
is_a: GO:0006690 ! icosanoid metabolic process

[Term]
id: GO:0006693
name: prostaglandin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "prostaglandin metabolism" EXACT []
is_a: GO:0006692 ! prostanoid metabolic process

[Term]
id: GO:0006694
name: steroid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators]
subset: gosubset_prok
synonym: "steroid anabolism" EXACT []
synonym: "steroid biosynthesis" EXACT []
synonym: "steroid formation" EXACT []
synonym: "steroid synthesis" EXACT []
synonym: "steroidogenesis" EXACT []
xref: Reactome:196071 "Steroid hormone biosynthesis"
xref: Reactome:448507 "Steroid hormone biosynthesis"
xref: Reactome:469637 "Steroid hormone biosynthesis"
xref: Reactome:487352 "Steroid hormone biosynthesis"
xref: Reactome:507303 "Steroid hormone biosynthesis"
xref: Reactome:517317 "Steroid hormone biosynthesis"
xref: Reactome:526506 "Steroid hormone biosynthesis"
xref: Reactome:531488 "Steroid hormone biosynthesis"
xref: Reactome:536874 "Steroid hormone biosynthesis"
xref: Reactome:542628 "Steroid hormone biosynthesis"
xref: Reactome:547943 "Steroid hormone biosynthesis"
xref: Reactome:552518 "Steroid hormone biosynthesis"
xref: Reactome:558118 "Steroid hormone biosynthesis"
xref: Reactome:568716 "Steroid hormone biosynthesis"
xref: Reactome:581919 "Steroid hormone biosynthesis"
xref: Reactome:586022 "Steroid hormone biosynthesis"
xref: Reactome:592856 "Steroid hormone biosynthesis"
xref: Reactome:595579 "Steroid hormone biosynthesis"
xref: Reactome:602603 "Steroid hormone biosynthesis"
xref: Wikipedia:Steroid_metabolisms#Steroid_biosynthesis
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0006695
name: cholesterol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai]
synonym: "cholesterol anabolism" EXACT []
synonym: "cholesterol biosynthesis" EXACT []
synonym: "cholesterol formation" EXACT []
synonym: "cholesterol synthesis" EXACT []
xref: Reactome:191273 "Cholesterol biosynthesis"
xref: Reactome:191345 "Transformation of lanosterol to cholesterol"
xref: Reactome:448588 "Transformation of lanosterol to cholesterol"
xref: Reactome:448589 "Cholesterol biosynthesis"
xref: Reactome:469717 "Transformation of lanosterol to cholesterol"
xref: Reactome:469718 "Cholesterol biosynthesis"
xref: Reactome:487429 "Transformation of lanosterol to cholesterol"
xref: Reactome:487430 "Cholesterol biosynthesis"
xref: Reactome:507385 "Transformation of lanosterol to cholesterol"
xref: Reactome:507386 "Cholesterol biosynthesis"
xref: Reactome:517388 "Transformation of lanosterol to cholesterol"
xref: Reactome:517389 "Cholesterol biosynthesis"
xref: Reactome:526262 "Transformation of lanosterol to cholesterol"
xref: Reactome:526263 "Cholesterol biosynthesis"
xref: Reactome:531135 "Transformation of lanosterol to cholesterol"
xref: Reactome:531136 "Cholesterol biosynthesis"
xref: Reactome:536507 "Transformation of lanosterol to cholesterol"
xref: Reactome:536508 "Cholesterol biosynthesis"
xref: Reactome:542222 "Transformation of lanosterol to cholesterol"
xref: Reactome:542223 "Cholesterol biosynthesis"
xref: Reactome:547570 "Transformation of lanosterol to cholesterol"
xref: Reactome:547571 "Cholesterol biosynthesis"
xref: Reactome:552183 "Transformation of lanosterol to cholesterol"
xref: Reactome:552184 "Cholesterol biosynthesis"
xref: Reactome:557768 "Transformation of lanosterol to cholesterol"
xref: Reactome:557769 "Cholesterol biosynthesis"
xref: Reactome:568380 "Transformation of lanosterol to cholesterol"
xref: Reactome:568381 "Cholesterol biosynthesis"
xref: Reactome:581582 "Transformation of lanosterol to cholesterol"
xref: Reactome:581583 "Cholesterol biosynthesis"
xref: Reactome:592477 "Transformation of lanosterol to cholesterol"
xref: Reactome:592478 "Cholesterol biosynthesis"
xref: Reactome:597331 "Cholesterol biosynthesis"
xref: Reactome:598168 "Cholesterol biosynthesis"
xref: Reactome:599651 "Transformation of lanosterol to cholesterol"
xref: Reactome:599652 "Cholesterol biosynthesis"
xref: Reactome:602465 "Transformation of lanosterol to cholesterol"
xref: Reactome:602466 "Cholesterol biosynthesis"
is_a: GO:0008203 ! cholesterol metabolic process
is_a: GO:0016126 ! sterol biosynthetic process

[Term]
id: GO:0006696
name: ergosterol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ergosterol anabolism" EXACT []
synonym: "ergosterol biosynthesis" EXACT []
synonym: "ergosterol formation" EXACT []
synonym: "ergosterol synthesis" EXACT []
is_a: GO:0008204 ! ergosterol metabolic process
is_a: GO:0016126 ! sterol biosynthetic process
is_a: GO:0016129 ! phytosteroid biosynthetic process

[Term]
id: GO:0006697
name: ecdysone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "ecdysone anabolism" EXACT []
synonym: "ecdysone biosynthesis" EXACT []
synonym: "ecdysone formation" EXACT []
synonym: "ecdysone synthesis" EXACT []
is_a: GO:0008205 ! ecdysone metabolic process
is_a: GO:0016126 ! sterol biosynthetic process
is_a: GO:0045456 ! ecdysteroid biosynthetic process

[Term]
id: GO:0006698
name: ecdysone modification
namespace: biological_process
def: "OBSOLETE. The covalent or conformational alteration of ecdysone, resulting in a change in its properties." [GOC:jl]
comment: This term was made obsolete because it was created to cover the conversion of ecdysone to its active form ecdysterone (20-hydroxyecdysone), but this reaction is carried out in a single step by ecdysone 20-monooxygenase (EC 1.14.99.22) and so is a function rather than a process.
is_obsolete: true
replaced_by: GO:0004501

[Term]
id: GO:0006699
name: bile acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators]
synonym: "bile acid anabolism" EXACT []
synonym: "bile acid biosynthesis" EXACT []
synonym: "bile acid formation" EXACT []
synonym: "bile acid synthesis" EXACT []
xref: Reactome:192105 "Synthesis of bile acids and bile salts"
xref: Reactome:193368 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:193775 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:193807 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:448454 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:448455 "Synthesis of bile acids and bile salts"
xref: Reactome:448568 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:448575 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:469584 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:469585 "Synthesis of bile acids and bile salts"
xref: Reactome:469697 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:469704 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:487303 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:487304 "Synthesis of bile acids and bile salts"
xref: Reactome:487412 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:487416 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:507254 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:507255 "Synthesis of bile acids and bile salts"
xref: Reactome:507371 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:507379 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:517276 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:517277 "Synthesis of bile acids and bile salts"
xref: Reactome:517380 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:517391 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:526154 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:526155 "Synthesis of bile acids and bile salts"
xref: Reactome:526256 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:526265 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:531051 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:531052 "Synthesis of bile acids and bile salts"
xref: Reactome:531138 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:531139 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:536433 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:536434 "Synthesis of bile acids and bile salts"
xref: Reactome:536502 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:536510 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:542130 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:542131 "Synthesis of bile acids and bile salts"
xref: Reactome:542215 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:542225 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:547574 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:547575 "Synthesis of bile acids and bile salts"
xref: Reactome:547577 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:547578 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:552162 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:552163 "Synthesis of bile acids and bile salts"
xref: Reactome:552186 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:552187 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:557750 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:557751 "Synthesis of bile acids and bile salts"
xref: Reactome:557771 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:557772 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:568286 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:568287 "Synthesis of bile acids and bile salts"
xref: Reactome:568383 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:568384 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:581488 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:581489 "Synthesis of bile acids and bile salts"
xref: Reactome:581585 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:581586 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:585784 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:585785 "Synthesis of bile acids and bile salts"
xref: Reactome:585788 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:585789 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:592385 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:592386 "Synthesis of bile acids and bile salts"
xref: Reactome:592480 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:592481 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:595598 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:595599 "Synthesis of bile acids and bile salts"
xref: Reactome:597298 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:597299 "Synthesis of bile acids and bile salts"
xref: Reactome:597302 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:597303 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:598214 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:598215 "Synthesis of bile acids and bile salts"
xref: Reactome:599644 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:599645 "Synthesis of bile acids and bile salts"
xref: Reactome:599653 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:599654 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
xref: Reactome:600706 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:600707 "Synthesis of bile acids and bile salts"
xref: Reactome:602386 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
xref: Reactome:602387 "Synthesis of bile acids and bile salts"
xref: Reactome:602457 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
xref: Reactome:602467 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0008206 ! bile acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0006700
name: C21-steroid hormone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai]
synonym: "C21-steroid hormone anabolism" EXACT []
synonym: "C21-steroid hormone biosynthesis" EXACT []
synonym: "C21-steroid hormone formation" EXACT []
synonym: "C21-steroid hormone synthesis" EXACT []
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0008207 ! C21-steroid hormone metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0006701
name: progesterone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/]
synonym: "progesterone anabolism" EXACT []
synonym: "progesterone biosynthesis" EXACT []
synonym: "progesterone formation" EXACT []
synonym: "progesterone synthesis" EXACT []
xref: Reactome:196108 "Pregnenolone biosynthesis"
xref: Reactome:448566 "Pregnenolone biosynthesis"
xref: Reactome:469695 "Pregnenolone biosynthesis"
xref: Reactome:487407 "Pregnenolone biosynthesis"
xref: Reactome:507359 "Pregnenolone biosynthesis"
xref: Reactome:526505 "Pregnenolone biosynthesis"
is_a: GO:0006700 ! C21-steroid hormone biosynthetic process
is_a: GO:0042448 ! progesterone metabolic process

[Term]
id: GO:0006702
name: androgen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "androgen anabolism" EXACT []
synonym: "androgen biosynthesis" EXACT []
synonym: "androgen formation" EXACT []
synonym: "androgen synthesis" EXACT []
xref: Reactome:193048 "Androgen biosynthesis"
xref: Reactome:449028 "Androgen biosynthesis"
xref: Reactome:470141 "Androgen biosynthesis"
xref: Reactome:487840 "Androgen biosynthesis"
xref: Reactome:507801 "Androgen biosynthesis"
xref: Reactome:517720 "Androgen biosynthesis"
xref: Reactome:526629 "Androgen biosynthesis"
xref: Reactome:531487 "Androgen biosynthesis"
xref: Reactome:536873 "Androgen biosynthesis"
xref: Reactome:542627 "Androgen biosynthesis"
xref: Reactome:547942 "Androgen biosynthesis"
xref: Reactome:552517 "Androgen biosynthesis"
xref: Reactome:558141 "Androgen biosynthesis"
xref: Reactome:568715 "Androgen biosynthesis"
xref: Reactome:581918 "Androgen biosynthesis"
xref: Reactome:586021 "Androgen biosynthesis"
xref: Reactome:592878 "Androgen biosynthesis"
xref: Reactome:595578 "Androgen biosynthesis"
xref: Reactome:602613 "Androgen biosynthesis"
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0008209 ! androgen metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0006703
name: estrogen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "estrogen anabolism" EXACT []
synonym: "estrogen biosynthesis" EXACT []
synonym: "estrogen formation" EXACT []
synonym: "estrogen synthesis" EXACT []
synonym: "oestrogen biosynthesis" EXACT []
synonym: "oestrogen biosynthetic process" EXACT []
xref: Reactome:193144 "Estrogen biosynthesis"
xref: Reactome:448771 "Estrogen biosynthesis"
xref: Reactome:469886 "Estrogen biosynthesis"
xref: Reactome:487591 "Estrogen biosynthesis"
xref: Reactome:507546 "Estrogen biosynthesis"
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0008210 ! estrogen metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0006704
name: glucocorticoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "glucocorticoid anabolism" EXACT []
synonym: "glucocorticoid biosynthesis" EXACT []
synonym: "glucocorticoid formation" EXACT []
synonym: "glucocorticoid synthesis" EXACT []
xref: Reactome:194002 "Glucocorticoid biosynthesis"
xref: Reactome:448506 "Glucocorticoid biosynthesis"
xref: Reactome:469636 "Glucocorticoid biosynthesis"
xref: Reactome:487351 "Glucocorticoid biosynthesis"
xref: Reactome:507302 "Glucocorticoid biosynthesis"
xref: Reactome:517316 "Glucocorticoid biosynthesis"
xref: Reactome:526630 "Glucocorticoid biosynthesis"
xref: Reactome:558117 "Glucocorticoid biosynthesis"
xref: Reactome:568718 "Glucocorticoid biosynthesis"
xref: Reactome:581921 "Glucocorticoid biosynthesis"
xref: Reactome:592855 "Glucocorticoid biosynthesis"
xref: Reactome:602602 "Glucocorticoid biosynthesis"
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0008211 ! glucocorticoid metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0006705
name: mineralocorticoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "mineralocorticoid anabolism" EXACT []
synonym: "mineralocorticoid biosynthesis" EXACT []
synonym: "mineralocorticoid formation" EXACT []
synonym: "mineralocorticoid synthesis" EXACT []
xref: Reactome:193993 "Mineralocorticoid biosynthesis"
xref: Reactome:448567 "Mineralocorticoid biosynthesis"
xref: Reactome:469696 "Mineralocorticoid biosynthesis"
xref: Reactome:488059 "Mineralocorticoid biosynthesis"
xref: Reactome:507364 "Mineralocorticoid biosynthesis"
xref: Reactome:517877 "Mineralocorticoid biosynthesis"
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0008212 ! mineralocorticoid metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0006706
name: steroid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators]
subset: gosubset_prok
synonym: "steroid breakdown" EXACT []
synonym: "steroid catabolism" EXACT []
synonym: "steroid degradation" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0016042 ! lipid catabolic process

[Term]
id: GO:0006707
name: cholesterol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai]
synonym: "cholesterol breakdown" EXACT []
synonym: "cholesterol catabolism" EXACT []
synonym: "cholesterol degradation" EXACT []
is_a: GO:0008203 ! cholesterol metabolic process
is_a: GO:0016127 ! sterol catabolic process

[Term]
id: GO:0006708
name: ecdysone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "ecdysone breakdown" EXACT []
synonym: "ecdysone catabolism" EXACT []
synonym: "ecdysone degradation" EXACT []
is_a: GO:0008205 ! ecdysone metabolic process
is_a: GO:0016127 ! sterol catabolic process
is_a: GO:0046344 ! ecdysteroid catabolic process

[Term]
id: GO:0006709
name: progesterone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/]
synonym: "progesterone breakdown" EXACT []
synonym: "progesterone catabolism" EXACT []
synonym: "progesterone degradation" EXACT []
is_a: GO:0008208 ! C21-steroid hormone catabolic process
is_a: GO:0042448 ! progesterone metabolic process

[Term]
id: GO:0006710
name: androgen catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "androgen breakdown" EXACT []
synonym: "androgen catabolism" EXACT []
synonym: "androgen degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008209 ! androgen metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0006711
name: estrogen catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "estrogen breakdown" EXACT []
synonym: "estrogen catabolism" EXACT []
synonym: "estrogen degradation" EXACT []
synonym: "oestrogen catabolic process" EXACT []
synonym: "oestrogen catabolism" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008210 ! estrogen metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0006712
name: mineralocorticoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "mineralocorticoid breakdown" EXACT []
synonym: "mineralocorticoid catabolism" EXACT []
synonym: "mineralocorticoid degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008212 ! mineralocorticoid metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0006713
name: glucocorticoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "glucocorticoid breakdown" EXACT []
synonym: "glucocorticoid catabolism" EXACT []
synonym: "glucocorticoid degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008211 ! glucocorticoid metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0006714
name: sesquiterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units." [ISBN:0198547684]
subset: gosubset_prok
synonym: "sesquiterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process
is_a: GO:0051761 ! sesquiterpene metabolic process

[Term]
id: GO:0006715
name: farnesol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [ISBN:0198547684]
subset: gosubset_prok
synonym: "farnesol anabolism" EXACT []
synonym: "farnesol biosynthesis" EXACT []
synonym: "farnesol formation" EXACT []
synonym: "farnesol synthesis" EXACT []
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0016487 ! farnesol metabolic process
is_a: GO:0034309 ! monohydric alcohol biosynthetic process

[Term]
id: GO:0006716
name: juvenile hormone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684]
synonym: "juvenile hormone metabolism" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process

[Term]
id: GO:0006717
name: juvenile hormone binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
is_obsolete: true
consider: GO:0005500

[Term]
id: GO:0006718
name: juvenile hormone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684]
synonym: "juvenile hormone anabolism" EXACT []
synonym: "juvenile hormone biosynthesis" EXACT []
synonym: "juvenile hormone formation" EXACT []
synonym: "juvenile hormone synthesis" EXACT []
is_a: GO:0006716 ! juvenile hormone metabolic process
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0006719
name: juvenile hormone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684]
synonym: "juvenile hormone breakdown" EXACT []
synonym: "juvenile hormone catabolism" EXACT []
synonym: "juvenile hormone degradation" EXACT []
is_a: GO:0006716 ! juvenile hormone metabolic process
is_a: GO:0016107 ! sesquiterpenoid catabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0006720
name: isoprenoid metabolic process
namespace: biological_process
alt_id: GO:0016096
def: "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684]
subset: gosubset_prok
synonym: "isoprenoid metabolism" EXACT []
synonym: "polyisoprenoid metabolic process" NARROW []
synonym: "polyisoprenoid metabolism" NARROW []
synonym: "polyterpene metabolic process" NARROW []
synonym: "polyterpene metabolism" NARROW []
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0006721
name: terpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "terpenoid metabolism" EXACT []
is_a: GO:0006720 ! isoprenoid metabolic process
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:0006722
name: triterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving triterpenoid compounds, terpenoids with six isoprene units." [ISBN:0198547684]
subset: gosubset_prok
synonym: "triterpene metabolic process" NARROW []
synonym: "triterpene metabolism" NARROW []
synonym: "triterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0006723
name: cuticle hydrocarbon biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [GOC:ai]
synonym: "cuticle hydrocarbon anabolism" EXACT []
synonym: "cuticle hydrocarbon biosynthesis" EXACT []
synonym: "cuticle hydrocarbon formation" EXACT []
synonym: "cuticle hydrocarbon synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
relationship: part_of GO:0042335 ! cuticle development

[Term]
id: GO:0006725
name: cellular aromatic compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "aromatic compound metabolism" EXACT []
synonym: "aromatic hydrocarbon metabolic process" NARROW []
synonym: "aromatic hydrocarbon metabolism" NARROW []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006726
name: eye pigment biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]
synonym: "eye pigment anabolism" EXACT []
synonym: "eye pigment biosynthesis" EXACT []
synonym: "eye pigment formation" EXACT []
synonym: "eye pigment synthesis" EXACT []
is_a: GO:0042441 ! eye pigment metabolic process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0006727
name: ommochrome biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "ommochrome anabolism" EXACT []
synonym: "ommochrome biosynthesis" EXACT []
synonym: "ommochrome formation" EXACT []
synonym: "ommochrome synthesis" EXACT []
is_a: GO:0006726 ! eye pigment biosynthetic process
is_a: GO:0008055 ! ocellus pigment biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0046152 ! ommochrome metabolic process

[Term]
id: GO:0006728
name: pteridine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pteridine anabolism" EXACT []
synonym: "pteridine biosynthesis" EXACT []
synonym: "pteridine formation" EXACT []
synonym: "pteridine synthesis" EXACT []
synonym: "pterin biosynthesis" NARROW []
synonym: "pterin biosynthetic process" NARROW []
is_a: GO:0019889 ! pteridine metabolic process
is_a: GO:0042559 ! pteridine and derivative biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0006729
name: tetrahydrobiopterin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "tetrahydrobiopterin anabolism" EXACT []
synonym: "tetrahydrobiopterin biosynthesis" EXACT []
synonym: "tetrahydrobiopterin formation" EXACT []
synonym: "tetrahydrobiopterin synthesis" EXACT []
is_a: GO:0042559 ! pteridine and derivative biosynthetic process
is_a: GO:0046146 ! tetrahydrobiopterin metabolic process

[Term]
id: GO:0006730
name: one-carbon metabolic process
namespace: biological_process
alt_id: GO:0019753
alt_id: GO:0019754
def: "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde]
subset: goslim_pir
subset: gosubset_prok
synonym: "one carbon metabolic process" EXACT [GOC:mah]
synonym: "one carbon metabolism" EXACT [GOC:mah]
synonym: "one-carbon metabolism" EXACT [GOC:mah]
synonym: "one-carbon transfer metabolic process" EXACT [GOC:mah]
synonym: "one-carbon transfer metabolism" EXACT [GOC:mah]
xref: UM-BBD_pathwayID:C1cyc
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0006731
name: coenzyme and prosthetic group metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
is_obsolete: true
consider: GO:0006732
consider: GO:0051189

[Term]
id: GO:0006732
name: coenzyme metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "coenzyme and prosthetic group metabolic process" BROAD []
synonym: "coenzyme and prosthetic group metabolism" BROAD []
synonym: "coenzyme metabolism" EXACT []
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0006733
name: oxidoreduction coenzyme metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed." [GOC:mah]
subset: gosubset_prok
synonym: "oxidoreduction coenzyme metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process

[Term]
id: GO:0006734
name: NADH metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]
subset: gosubset_prok
synonym: "NAD (reduced) metabolic process" EXACT []
synonym: "NAD (reduced) metabolism" EXACT []
synonym: "NADH metabolism" EXACT []
synonym: "reduced NAD metabolic process" EXACT []
synonym: "reduced NAD metabolism" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide metabolic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide metabolism" EXACT []
is_a: GO:0019674 ! NAD metabolic process

[Term]
id: GO:0006735
name: NADH regeneration
namespace: biological_process
subset: gosubset_prok
synonym: "NAD (reduced) regeneration" EXACT []
synonym: "reduced NAD regeneration" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide regeneration" EXACT []
is_a: GO:0006734 ! NADH metabolic process

[Term]
id: GO:0006738
name: nicotinamide riboside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "N-ribosylnicotinamide catabolic process" EXACT [ChEBI:15927]
synonym: "nicotinamide riboside breakdown" EXACT []
synonym: "nicotinamide riboside catabolism" EXACT []
synonym: "nicotinamide riboside degradation" EXACT []
is_a: GO:0046495 ! nicotinamide riboside metabolic process
is_a: GO:0070638 ! pyridine nucleoside catabolic process

[Term]
id: GO:0006739
name: NADP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]
subset: gosubset_prok
synonym: "NAD phosphorylation and dephosphorylation" RELATED []
synonym: "NADP (oxidized) metabolic process" EXACT []
synonym: "NADP (oxidized) metabolism" EXACT []
synonym: "NADP (reduced) metabolic process" EXACT []
synonym: "NADP (reduced) metabolism" EXACT []
synonym: "NADP metabolism" EXACT []
synonym: "NADPH metabolic process" EXACT []
synonym: "NADPH metabolism" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate metabolic process" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate metabolism" EXACT []
synonym: "oxidized NADP metabolic process" EXACT []
synonym: "oxidized NADP metabolism" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolism" EXACT []
synonym: "reduced NADP metabolic process" EXACT []
synonym: "reduced NADP metabolism" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolism" EXACT []
is_a: GO:0006769 ! nicotinamide metabolic process
is_a: GO:0046496 ! nicotinamide nucleotide metabolic process

[Term]
id: GO:0006740
name: NADPH regeneration
namespace: biological_process
subset: gosubset_prok
synonym: "NADP (reduced) regeneration" EXACT []
synonym: "reduced NADP regeneration" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate regeneration" EXACT []
xref: Reactome:389542 "NADPH regeneration"
xref: Reactome:449171 "NADPH regeneration"
xref: Reactome:470284 "NADPH regeneration"
xref: Reactome:487955 "NADPH regeneration"
xref: Reactome:507934 "NADPH regeneration"
xref: Reactome:517805 "NADPH regeneration"
xref: Reactome:526639 "NADPH regeneration"
xref: Reactome:531437 "NADPH regeneration"
xref: Reactome:536810 "NADPH regeneration"
xref: Reactome:542569 "NADPH regeneration"
xref: Reactome:547889 "NADPH regeneration"
xref: Reactome:552468 "NADPH regeneration"
xref: Reactome:558074 "NADPH regeneration"
xref: Reactome:568724 "NADPH regeneration"
xref: Reactome:581927 "NADPH regeneration"
xref: Reactome:592819 "NADPH regeneration"
xref: Reactome:595540 "NADPH regeneration"
xref: Reactome:602573 "NADPH regeneration"
is_a: GO:0006739 ! NADP metabolic process

[Term]
id: GO:0006741
name: NADP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]
subset: gosubset_prok
synonym: "NADP (oxidized) biosynthesis" EXACT []
synonym: "NADP (oxidized) biosynthetic process" EXACT []
synonym: "NADP (reduced) biosynthesis" EXACT []
synonym: "NADP (reduced) biosynthetic process" EXACT []
synonym: "NADP anabolism" EXACT []
synonym: "NADP biosynthesis" EXACT []
synonym: "NADP formation" EXACT []
synonym: "NADP synthesis" EXACT []
synonym: "NADPH biosynthesis" EXACT []
synonym: "NADPH biosynthetic process" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT []
synonym: "oxidized NADP biosynthesis" EXACT []
synonym: "oxidized NADP biosynthetic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT []
synonym: "reduced NADP biosynthesis" EXACT []
synonym: "reduced NADP biosynthetic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT []
is_a: GO:0006739 ! NADP metabolic process
is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process

[Term]
id: GO:0006742
name: NADP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; catabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah]
subset: gosubset_prok
synonym: "NADP (oxidized) catabolic process" EXACT []
synonym: "NADP (oxidized) catabolism" EXACT []
synonym: "NADP (reduced) catabolic process" EXACT []
synonym: "NADP (reduced) catabolism" EXACT []
synonym: "NADP breakdown" EXACT []
synonym: "NADP catabolism" EXACT []
synonym: "NADP degradation" EXACT []
synonym: "NADPH catabolic process" EXACT []
synonym: "NADPH catabolism" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate catabolic process" EXACT []
synonym: "nicotinamide adenine dinucleotide phosphate catabolism" EXACT []
synonym: "oxidized NADP catabolic process" EXACT []
synonym: "oxidized NADP catabolism" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolism" EXACT []
synonym: "reduced NADP catabolic process" EXACT []
synonym: "reduced NADP catabolism" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolism" EXACT []
is_a: GO:0006739 ! NADP metabolic process
is_a: GO:0019364 ! pyridine nucleotide catabolic process

[Term]
id: GO:0006743
name: ubiquinone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]
subset: gosubset_prok
synonym: "coenzyme Q metabolic process" EXACT []
synonym: "coenzyme Q metabolism" EXACT []
synonym: "coenzyme Q6 metabolic process" NARROW []
synonym: "coenzyme Q6 metabolism" NARROW []
synonym: "ubiquinone metabolism" EXACT []
is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0042375 ! quinone cofactor metabolic process

[Term]
id: GO:0006744
name: ubiquinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]
subset: gosubset_prok
synonym: "coenzyme Q biosynthesis" EXACT []
synonym: "coenzyme Q biosynthetic process" EXACT []
synonym: "coenzyme Q10 biosynthesis" NARROW []
synonym: "coenzyme Q10 biosynthetic process" NARROW []
synonym: "coenzyme Q6 biosynthesis" NARROW []
synonym: "coenzyme Q6 biosynthetic process" NARROW []
synonym: "coenzyme Q8 biosynthesis" NARROW []
synonym: "coenzyme Q8 biosynthetic process" NARROW []
synonym: "coenzyme Q9 biosynthesis" NARROW []
synonym: "coenzyme Q9 biosynthetic process" NARROW []
synonym: "ubiquinone anabolism" EXACT []
synonym: "ubiquinone biosynthesis" EXACT []
synonym: "ubiquinone formation" EXACT []
synonym: "ubiquinone synthesis" EXACT []
xref: MetaCyc:UBISYN-PWY
is_a: GO:0006743 ! ubiquinone metabolic process
is_a: GO:0045426 ! quinone cofactor biosynthetic process

[Term]
id: GO:0006746
name: FADH2 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the reduced form of flavin-adenine dinucleotide." [GOC:ai]
subset: gosubset_prok
synonym: "FADH2 metabolism" EXACT []
is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process
is_a: GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0006747
name: FAD biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "FAD anabolism" EXACT []
synonym: "FAD biosynthesis" EXACT []
synonym: "FAD formation" EXACT []
synonym: "FAD synthesis" EXACT []
synonym: "flavin adenine dinucleotide biosynthesis" EXACT []
synonym: "flavin adenine dinucleotide biosynthetic process" EXACT []
synonym: "flavin-adenine dinucleotide biosynthesis" EXACT []
synonym: "flavin-adenine dinucleotide biosynthetic process" EXACT []
is_a: GO:0006746 ! FADH2 metabolic process
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0042727 ! riboflavin and derivative biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0046443 ! FAD metabolic process

[Term]
id: GO:0006748
name: lipoamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "lipoamide metabolism" EXACT []
is_a: GO:0000273 ! lipoic acid metabolic process
is_a: GO:0043603 ! cellular amide metabolic process

[Term]
id: GO:0006749
name: glutathione metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glutathione metabolism" EXACT []
synonym: "oxidized glutathione reduction" NARROW []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0006750
name: glutathione biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glutathione anabolism" EXACT []
synonym: "glutathione biosynthesis" EXACT []
synonym: "glutathione formation" EXACT []
synonym: "glutathione synthesis" EXACT []
xref: MetaCyc:GLUTATHIONESYN-PWY
xref: Reactome:174403 "Glutathione synthesis"
xref: Reactome:449125 "Glutathione synthesis"
xref: Reactome:470235 "Glutathione synthesis"
xref: Reactome:487918 "Glutathione synthesis"
xref: Reactome:507890 "Glutathione synthesis"
xref: Reactome:517782 "Glutathione synthesis"
xref: Reactome:526613 "Glutathione synthesis"
xref: Reactome:531412 "Glutathione synthesis"
xref: Reactome:536783 "Glutathione synthesis"
xref: Reactome:542541 "Glutathione synthesis"
xref: Reactome:547869 "Glutathione synthesis"
xref: Reactome:552441 "Glutathione synthesis"
xref: Reactome:558053 "Glutathione synthesis"
xref: Reactome:568699 "Glutathione synthesis"
xref: Reactome:581901 "Glutathione synthesis"
xref: Reactome:592799 "Glutathione synthesis"
xref: Reactome:595527 "Glutathione synthesis"
is_a: GO:0006749 ! glutathione metabolic process
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0006751
name: glutathione catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glutathione breakdown" EXACT []
synonym: "glutathione catabolism" EXACT []
synonym: "glutathione degradation" EXACT []
is_a: GO:0006749 ! glutathione metabolic process
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0042219 ! cellular amino acid derivative catabolic process
is_a: GO:0043171 ! peptide catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0006752
name: group transfer coenzyme metabolic process
namespace: biological_process
subset: gosubset_prok
synonym: "group transfer coenzyme metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process

[Term]
id: GO:0006753
name: nucleoside phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah]
subset: gosubset_prok
synonym: "nucleoside phosphate metabolism" EXACT []
is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process

[Term]
id: GO:0006754
name: ATP biosynthetic process
namespace: biological_process
alt_id: GO:0006758
def: "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ATP anabolism" EXACT []
synonym: "ATP biosynthesis" EXACT []
synonym: "ATP formation" EXACT []
synonym: "ATP synthesis" EXACT []
xref: Reactome:164832 "ATP is synthesized from ADP and Pi by ATPase"
xref: Reactome:164840 "ADP and Pi bind to ATPase"
xref: Reactome:430384 "ADP and Pi bind to ATPase"
xref: Reactome:432411 "ATP is synthesized from ADP and Pi by ATPase"
xref: Reactome:448753 "ATP formation"
xref: Reactome:452635 "ADP and Pi bind to ATPase"
xref: Reactome:454975 "ATP is synthesized from ADP and Pi by ATPase"
xref: Reactome:469868 "ATP formation"
xref: Reactome:473194 "ADP and Pi bind to ATPase"
xref: Reactome:474935 "ATP is synthesized from ADP and Pi by ATPase"
xref: Reactome:487572 "ATP formation"
xref: Reactome:491585 "ADP and Pi bind to ATPase"
xref: Reactome:493796 "ATP is synthesized from ADP and Pi by ATPase"
xref: Reactome:507528 "ATP formation"
xref: Reactome:517512 "ATP formation"
xref: Reactome:526381 "ATP formation"
xref: Reactome:531199 "ATP formation"
xref: Reactome:536574 "ATP formation"
xref: Reactome:542300 "ATP formation"
xref: Reactome:547641 "ATP formation"
xref: Reactome:552233 "ATP formation"
xref: Reactome:557838 "ATP formation"
xref: Reactome:568440 "ATP formation"
xref: Reactome:581642 "ATP formation"
xref: Reactome:585804 "ATP formation"
xref: Reactome:592554 "ATP formation"
xref: Reactome:595374 "ATP formation"
xref: Reactome:597332 "ATP formation"
xref: Reactome:598137 "ATP formation"
xref: Reactome:599763 "ATP formation"
xref: Reactome:600598 "ATP formation"
xref: Reactome:602499 "ATP formation"
xref: Reactome:74226 "ATP formation"
is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process
is_a: GO:0046034 ! ATP metabolic process

[Term]
id: GO:0006755
name: carbamoyl phosphate-ADP transphosphorylation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because, according to PUMA2, this "pathway" is a single reaction, corresponding to 'carbamate kinase activity ; GO:0008804' (EC:2.7.2.2).
is_obsolete: true

[Term]
id: GO:0006756
name: AMP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into AMP, adenosine monophosphate, to produce ADP. Addition of two phosphate groups produces ATP." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006754 ! ATP biosynthetic process
is_a: GO:0046033 ! AMP metabolic process
is_a: GO:0046940 ! nucleoside monophosphate phosphorylation

[Term]
id: GO:0006757
name: ADP phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006165 ! nucleoside diphosphate phosphorylation
is_a: GO:0006754 ! ATP biosynthetic process
is_a: GO:0046031 ! ADP metabolic process

[Term]
id: GO:0006759
name: ATP regeneration
namespace: biological_process
subset: gosubset_prok
is_a: GO:0006754 ! ATP biosynthetic process

[Term]
id: GO:0006760
name: folic acid and derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving folic acid and its derivatives." [GOC:ai]
subset: gosubset_prok
synonym: "folate and derivative metabolic process" EXACT []
synonym: "folate and derivative metabolism" EXACT []
synonym: "folic acid and derivative metabolism" EXACT []
synonym: "vitamin B9 and derivative metabolic process" EXACT []
synonym: "vitamin B9 and derivative metabolism" EXACT []
synonym: "vitamin M and derivative metabolic process" EXACT []
synonym: "vitamin M and derivative metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006752 ! group transfer coenzyme metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0006761
name: dihydrofolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dihydrofolate, the dihydroxylated derivative of folate." [GOC:ai]
subset: gosubset_prok
synonym: "7,8-dihydrofolate biosynthesis" EXACT []
synonym: "7,8-dihydrofolate biosynthetic process" EXACT []
synonym: "dihydrofolate anabolism" EXACT []
synonym: "dihydrofolate biosynthesis" EXACT []
synonym: "dihydrofolate formation" EXACT []
synonym: "dihydrofolate synthesis" EXACT []
is_a: GO:0009396 ! folic acid and derivative biosynthetic process
is_a: GO:0042559 ! pteridine and derivative biosynthetic process
is_a: GO:0046452 ! dihydrofolate metabolic process

[Term]
id: GO:0006762
name: dihydrofolate reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
is_obsolete: true
consider: GO:0004146
consider: GO:0046452

[Term]
id: GO:0006766
name: vitamin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GOC:ai]
subset: goslim_candida
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "vitamin metabolism" EXACT []
xref: Reactome:196854 "Metabolism of vitamins and cofactors"
xref: Reactome:448501 "Metabolism of vitamins and cofactors"
xref: Reactome:469631 "Metabolism of vitamins and cofactors"
xref: Reactome:487350 "Metabolism of vitamins and cofactors"
xref: Reactome:507301 "Metabolism of vitamins and cofactors"
xref: Reactome:517315 "Metabolism of vitamins and cofactors"
xref: Reactome:526200 "Metabolism of vitamins and cofactors"
xref: Reactome:531086 "Metabolism of vitamins and cofactors"
xref: Reactome:536459 "Metabolism of vitamins and cofactors"
xref: Reactome:542163 "Metabolism of vitamins and cofactors"
xref: Reactome:547521 "Metabolism of vitamins and cofactors"
xref: Reactome:552114 "Metabolism of vitamins and cofactors"
xref: Reactome:557706 "Metabolism of vitamins and cofactors"
xref: Reactome:568321 "Metabolism of vitamins and cofactors"
xref: Reactome:581523 "Metabolism of vitamins and cofactors"
xref: Reactome:585808 "Metabolism of vitamins and cofactors"
xref: Reactome:592410 "Metabolism of vitamins and cofactors"
xref: Reactome:595340 "Metabolism of vitamins and cofactors"
xref: Reactome:597308 "Metabolism of vitamins and cofactors"
xref: Reactome:598109 "Metabolism of vitamins and cofactors"
xref: Reactome:599609 "Metabolism of vitamins and cofactors"
xref: Reactome:600553 "Metabolism of vitamins and cofactors"
xref: Reactome:602413 "Metabolism of vitamins and cofactors"
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0006767
name: water-soluble vitamin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water." [GOC:jl]
subset: gosubset_prok
synonym: "water-soluble vitamin metabolism" EXACT []
xref: Reactome:196849 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:448500 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:469630 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:487349 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:507300 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:517314 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:526199 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:531085 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:536458 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:542162 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:547520 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:552113 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:557705 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:568320 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:581522 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:585807 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:592409 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:595339 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:597307 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:598108 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:599608 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:600552 "Metabolism of water-soluble vitamins and cofactors"
xref: Reactome:602412 "Metabolism of water-soluble vitamins and cofactors"
is_a: GO:0006766 ! vitamin metabolic process

[Term]
id: GO:0006768
name: biotin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "biotin metabolism" EXACT []
synonym: "vitamin B7 metabolic process" EXACT []
synonym: "vitamin B7 metabolism" EXACT []
synonym: "vitamin H metabolic process" EXACT []
synonym: "vitamin H metabolism" EXACT []
xref: Reactome:196780 "Biotin metabolism"
xref: Reactome:448934 "Biotin metabolism"
xref: Reactome:470052 "Biotin metabolism"
xref: Reactome:487751 "Biotin metabolism"
xref: Reactome:507707 "Biotin metabolism"
xref: Reactome:517644 "Biotin metabolism"
xref: Reactome:526482 "Biotin metabolism"
xref: Wikipedia:Biotin
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0006769
name: nicotinamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "niacin metabolic process" RELATED []
synonym: "niacin metabolism" RELATED []
synonym: "nicotinamide metabolism" EXACT []
synonym: "vitamin B3 metabolic process" BROAD []
synonym: "vitamin B3 metabolism" BROAD []
xref: MetaCyc:PWY-5083
xref: Reactome:197264 "Nicotinamide salvaging"
xref: Reactome:448612 "Nicotinamide salvaging"
xref: Reactome:469740 "Nicotinamide salvaging"
xref: Reactome:487447 "Nicotinamide salvaging"
xref: Reactome:507404 "Nicotinamide salvaging"
xref: Reactome:517406 "Nicotinamide salvaging"
xref: Reactome:526281 "Nicotinamide salvaging"
xref: Reactome:552196 "Nicotinamide salvaging"
xref: Reactome:557782 "Nicotinamide salvaging"
xref: Reactome:568395 "Nicotinamide salvaging"
xref: Reactome:581597 "Nicotinamide salvaging"
xref: Reactome:592493 "Nicotinamide salvaging"
xref: Reactome:595342 "Nicotinamide salvaging"
xref: Reactome:597316 "Nicotinamide salvaging"
xref: Reactome:599742 "Nicotinamide salvaging"
xref: Reactome:602477 "Nicotinamide salvaging"
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0019362 ! pyridine nucleotide metabolic process
is_a: GO:0043603 ! cellular amide metabolic process

[Term]
id: GO:0006771
name: riboflavin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "riboflavin metabolism" EXACT []
synonym: "vitamin B2 metabolic process" EXACT []
synonym: "vitamin B2 metabolism" EXACT []
synonym: "vitamin G metabolic process" EXACT []
synonym: "vitamin G metabolism" EXACT []
xref: Wikipedia:Riboflavin
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0042726 ! riboflavin and derivative metabolic process

[Term]
id: GO:0006772
name: thiamin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "thiamin metabolism" EXACT []
synonym: "thiamine metabolic process" EXACT []
synonym: "thiamine metabolism" EXACT []
synonym: "vitamin B1 metabolic process" EXACT []
synonym: "vitamin B1 metabolism" EXACT []
xref: Wikipedia:Thiamine
is_a: GO:0042723 ! thiamin and derivative metabolic process

[Term]
id: GO:0006774
name: vitamin B12 reduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
is_obsolete: true
consider: GO:0009235
consider: GO:0050453

[Term]
id: GO:0006775
name: fat-soluble vitamin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "fat-soluble vitamin metabolism" EXACT []
is_a: GO:0006766 ! vitamin metabolic process

[Term]
id: GO:0006776
name: vitamin A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "vitamin A metabolism" EXACT []
is_a: GO:0006720 ! isoprenoid metabolic process
is_a: GO:0006775 ! fat-soluble vitamin metabolic process

[Term]
id: GO:0006777
name: Mo-molybdopterin cofactor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257]
subset: gosubset_prok
synonym: "Mo-molybdopterin cofactor anabolism" EXACT []
synonym: "Mo-molybdopterin cofactor biosynthesis" EXACT []
synonym: "Mo-molybdopterin cofactor formation" EXACT []
synonym: "Mo-molybdopterin cofactor synthesis" EXACT []
synonym: "Moco biosynthesis" EXACT []
synonym: "Moco biosynthetic process" EXACT []
synonym: "molybdenum cofactor biosynthetic process" RELATED []
xref: MetaCyc:PWY-5354
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process
is_a: GO:0032324 ! molybdopterin cofactor biosynthetic process

[Term]
id: GO:0006778
name: porphyrin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "porphyrin metabolism" EXACT []
xref: Reactome:189445 "Metabolism of porphyrins"
xref: Reactome:448781 "Metabolism of porphyrins"
xref: Reactome:469896 "Metabolism of porphyrins"
xref: Reactome:487603 "Metabolism of porphyrins"
xref: Reactome:507558 "Metabolism of porphyrins"
xref: Reactome:517536 "Metabolism of porphyrins"
xref: Reactome:526732 "Metabolism of porphyrins"
xref: Reactome:531223 "Metabolism of porphyrins"
xref: Reactome:536593 "Metabolism of porphyrins"
xref: Reactome:542319 "Metabolism of porphyrins"
xref: Reactome:547659 "Metabolism of porphyrins"
xref: Reactome:552244 "Metabolism of porphyrins"
xref: Reactome:557863 "Metabolism of porphyrins"
xref: Reactome:568461 "Metabolism of porphyrins"
xref: Reactome:581672 "Metabolism of porphyrins"
xref: Reactome:592581 "Metabolism of porphyrins"
xref: Reactome:595395 "Metabolism of porphyrins"
xref: Reactome:597339 "Metabolism of porphyrins"
xref: Reactome:598144 "Metabolism of porphyrins"
xref: Reactome:599698 "Metabolism of porphyrins"
xref: Reactome:600605 "Metabolism of porphyrins"
xref: Reactome:602507 "Metabolism of porphyrins"
xref: Wikipedia:Porphyrin
is_a: GO:0033013 ! tetrapyrrole metabolic process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0006779
name: porphyrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "porphyrin anabolism" EXACT []
synonym: "porphyrin biosynthesis" EXACT []
synonym: "porphyrin formation" EXACT []
synonym: "porphyrin synthesis" EXACT []
is_a: GO:0006778 ! porphyrin metabolic process
is_a: GO:0033014 ! tetrapyrrole biosynthetic process
is_a: GO:0051188 ! cofactor biosynthetic process

[Term]
id: GO:0006780
name: uroporphyrinogen III biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of uroporphyrinogen III." [GOC:ai]
subset: gosubset_prok
synonym: "uroporphyrinogen III anabolism" EXACT []
synonym: "uroporphyrinogen III biosynthesis" EXACT []
synonym: "uroporphyrinogen III formation" EXACT []
synonym: "uroporphyrinogen III synthesis" EXACT []
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0046502 ! uroporphyrinogen III metabolic process
relationship: part_of GO:0006779 ! porphyrin biosynthetic process

[Term]
id: GO:0006781
name: succinyl-CoA pathway
namespace: biological_process
def: "The chemical reactions that utilize succinyl-CoA in the synthesis of protoporphyrin IX." [GOC:isa_complete, ISBN:0879010479]
subset: gosubset_prok
synonym: "biosynthesis of protoporphyrin IX via succinyl CoA" EXACT []
synonym: "biosynthesis of protoporphyrin IX via succinyl-CoA" EXACT []
synonym: "biosynthetic process of protoporphyrin IX via succinyl CoA" EXACT []
synonym: "biosynthetic process of protoporphyrin IX via succinyl-CoA" EXACT []
synonym: "succinyl CoA pathway" EXACT []
is_a: GO:0006104 ! succinyl-CoA metabolic process
is_a: GO:0006779 ! porphyrin biosynthetic process
relationship: part_of GO:0006780 ! uroporphyrinogen III biosynthetic process

[Term]
id: GO:0006782
name: protoporphyrinogen IX biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX." [GOC:go_curators]
subset: gosubset_prok
synonym: "protoporphyrinogen IX anabolism" EXACT []
synonym: "protoporphyrinogen IX biosynthesis" EXACT []
synonym: "protoporphyrinogen IX formation" EXACT []
synonym: "protoporphyrinogen IX synthesis" EXACT []
is_a: GO:0006779 ! porphyrin biosynthetic process
is_a: GO:0046501 ! protoporphyrinogen IX metabolic process
relationship: part_of GO:0006783 ! heme biosynthetic process

[Term]
id: GO:0006783
name: heme biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl]
subset: gosubset_prok
synonym: "haem biosynthesis" EXACT []
synonym: "haem biosynthetic process" EXACT []
synonym: "heme anabolism" EXACT []
synonym: "heme biosynthesis" EXACT []
synonym: "heme formation" EXACT []
synonym: "heme synthesis" EXACT []
xref: MetaCyc:HEMESYN2-PWY
xref: Reactome:189451 "Heme biosynthesis"
xref: Reactome:448780 "Heme biosynthesis"
xref: Reactome:469895 "Heme biosynthesis"
xref: Reactome:487602 "Heme biosynthesis"
xref: Reactome:507557 "Heme biosynthesis"
xref: Reactome:517535 "Heme biosynthesis"
xref: Reactome:526731 "Heme biosynthesis"
xref: Reactome:531222 "Heme biosynthesis"
xref: Reactome:536592 "Heme biosynthesis"
xref: Reactome:542318 "Heme biosynthesis"
xref: Reactome:547658 "Heme biosynthesis"
xref: Reactome:552243 "Heme biosynthesis"
xref: Reactome:557862 "Heme biosynthesis"
xref: Reactome:568460 "Heme biosynthesis"
xref: Reactome:581671 "Heme biosynthesis"
xref: Reactome:592580 "Heme biosynthesis"
xref: Reactome:595394 "Heme biosynthesis"
xref: Reactome:597338 "Heme biosynthesis"
xref: Reactome:598143 "Heme biosynthesis"
xref: Reactome:599697 "Heme biosynthesis"
xref: Reactome:600604 "Heme biosynthesis"
xref: Reactome:602506 "Heme biosynthesis"
is_a: GO:0006779 ! porphyrin biosynthetic process
is_a: GO:0042168 ! heme metabolic process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0006784
name: heme a biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heme a, a derivative of heme found in cytochrome aa3." [GOC:ai, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "haem a biosynthesis" EXACT []
synonym: "haem a biosynthetic process" EXACT []
synonym: "heme a anabolism" EXACT []
synonym: "heme a biosynthesis" EXACT []
synonym: "heme a formation" EXACT []
synonym: "heme a synthesis" EXACT []
is_a: GO:0006783 ! heme biosynthetic process
is_a: GO:0046160 ! heme a metabolic process

[Term]
id: GO:0006785
name: heme b biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [http://www.chem.qmul.ac.uk/iupac/bioinorg/PR.html#25]
subset: gosubset_prok
synonym: "haem b biosynthesis" EXACT []
synonym: "haem b biosynthetic process" EXACT []
synonym: "heme b anabolism" EXACT []
synonym: "heme b biosynthesis" EXACT []
synonym: "heme b formation" EXACT []
synonym: "heme b synthesis" EXACT []
is_a: GO:0006783 ! heme biosynthetic process
is_a: GO:0046492 ! heme b metabolic process

[Term]
id: GO:0006786
name: heme c biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heme c, a derivative of heme found in cytochromes c, b4, and f." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "haem c biosynthesis" EXACT []
synonym: "haem c biosynthetic process" EXACT []
synonym: "heme c anabolism" EXACT []
synonym: "heme c biosynthesis" EXACT []
synonym: "heme c formation" EXACT []
synonym: "heme c synthesis" EXACT []
is_a: GO:0006783 ! heme biosynthetic process
is_a: GO:0046162 ! heme c metabolic process

[Term]
id: GO:0006787
name: porphyrin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "porphyrin breakdown" EXACT []
synonym: "porphyrin catabolism" EXACT []
synonym: "porphyrin degradation" EXACT []
is_a: GO:0006778 ! porphyrin metabolic process
is_a: GO:0033015 ! tetrapyrrole catabolic process
is_a: GO:0051187 ! cofactor catabolic process

[Term]
id: GO:0006788
name: heme oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme." [GOC:mah]
subset: gosubset_prok
synonym: "haem oxidation" EXACT []
is_a: GO:0042168 ! heme metabolic process
relationship: part_of GO:0006787 ! porphyrin catabolic process

[Term]
id: GO:0006789
name: bilirubin conjugation
namespace: biological_process
subset: gosubset_prok
is_a: GO:0006787 ! porphyrin catabolic process

[Term]
id: GO:0006790
name: sulfur metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai]
subset: gosubset_prok
synonym: "sulfur metabolism" EXACT []
synonym: "sulphur metabolic process" EXACT []
synonym: "sulphur metabolism" EXACT []
xref: Wikipedia:Sulfur_metabolism
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006791
name: sulfur utilization
namespace: biological_process
subset: gosubset_prok
synonym: "sulphur utilization" EXACT []
is_a: GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0006792
name: regulation of sulfur utilization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sulfur utilization." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of sulphur utilization" EXACT []
is_a: GO:0042762 ! regulation of sulfur metabolic process
relationship: regulates GO:0006791 ! sulfur utilization

[Term]
id: GO:0006793
name: phosphorus metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4)." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "phosphorus metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006794
name: phosphorus utilization
namespace: biological_process
subset: gosubset_prok
is_a: GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0006795
name: regulation of phosphorus utilization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphorus utilization." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0051174 ! regulation of phosphorus metabolic process
relationship: regulates GO:0006794 ! phosphorus utilization

[Term]
id: GO:0006796
name: phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai]
subset: goslim_pombe
subset: gosubset_prok
synonym: "phosphate metabolism" EXACT []
is_a: GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0006797
name: polyphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "polyphosphate metabolism" EXACT []
is_a: GO:0006796 ! phosphate metabolic process

[Term]
id: GO:0006798
name: polyphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "polyphosphate breakdown" EXACT []
synonym: "polyphosphate catabolism" EXACT []
synonym: "polyphosphate degradation" EXACT []
is_a: GO:0006797 ! polyphosphate metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0006799
name: polyphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "polyphosphate anabolism" EXACT []
synonym: "polyphosphate biosynthesis" EXACT []
synonym: "polyphosphate formation" EXACT []
synonym: "polyphosphate synthesis" EXACT []
is_a: GO:0006797 ! polyphosphate metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0006800
name: oxygen and reactive oxygen species metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:jl, PMID:12115731]
subset: goslim_pir
subset: gosubset_prok
synonym: "oxygen and active oxygen species metabolism" EXACT []
synonym: "oxygen and AOS metabolism" EXACT []
synonym: "oxygen and reactive oxidative species metabolism" EXACT []
synonym: "oxygen and reactive oxygen intermediate metabolism" EXACT []
synonym: "oxygen and reactive oxygen species metabolism" EXACT []
synonym: "oxygen and ROI metabolism" EXACT []
synonym: "oxygen and ROS metabolic process" EXACT []
synonym: "oxygen and ROS metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0006801
name: superoxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "oxygen free radical metabolic process" EXACT []
synonym: "oxygen free radical metabolism" EXACT []
synonym: "superoxide free radical metabolic process" EXACT []
synonym: "superoxide free radical metabolism" EXACT []
synonym: "superoxide metabolism" EXACT []
is_a: GO:0006800 ! oxygen and reactive oxygen species metabolic process

[Term]
id: GO:0006802
name: catalase reaction
namespace: biological_process
def: "OBSOLETE. The processes involved in the induction or activation of catalase, an enzyme that catalyzes the conversion of H2O2 into H2O." [GOC:jl, PMID:11245904]
comment: This term was made obsolete because it represents a molecular function.
synonym: "hydroperoxidase reaction" RELATED []
is_obsolete: true
consider: GO:0004096

[Term]
id: GO:0006803
name: glutathione conjugation reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
is_obsolete: true
replaced_by: GO:0004364

[Term]
id: GO:0006804
name: peroxidase reaction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
is_obsolete: true
replaced_by: GO:0004601

[Term]
id: GO:0006805
name: xenobiotic metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:cab2]
subset: goslim_pir
subset: gosubset_prok
synonym: "xenobiotic metabolism" EXACT []
xref: Reactome:140191 "Phase 1 functionalization"
xref: Reactome:156580 "Phase II conjugation"
xref: Reactome:156587 "Amino Acid conjugation"
xref: Reactome:159424 "Conjugation of carboxylic acids"
xref: Reactome:177128 "Conjugation of salicylate with glycine"
xref: Reactome:177135 "Conjugation of benzoate with glycine"
xref: Reactome:177162 "Conjugation of phenylacetate with glutamine"
xref: Reactome:211859 "Biological oxidations"
xref: Reactome:211945 "Phase 1 - Functionalization of compounds"
xref: Reactome:448504 "Phase 1 - Functionalization of compounds"
xref: Reactome:448505 "Biological oxidations"
xref: Reactome:448574 "Phase II conjugation"
xref: Reactome:448625 "Phase 1 functionalization"
xref: Reactome:448895 "Conjugation of benzoate with glycine"
xref: Reactome:448896 "Conjugation of carboxylic acids"
xref: Reactome:448897 "Amino Acid conjugation"
xref: Reactome:449231 "Conjugation of phenylacetate with glutamine"
xref: Reactome:449280 "Conjugation of salicylate with glycine"
xref: Reactome:469634 "Phase 1 - Functionalization of compounds"
xref: Reactome:469635 "Biological oxidations"
xref: Reactome:469703 "Phase II conjugation"
xref: Reactome:469753 "Phase 1 functionalization"
xref: Reactome:470012 "Conjugation of benzoate with glycine"
xref: Reactome:470013 "Conjugation of carboxylic acids"
xref: Reactome:470014 "Amino Acid conjugation"
xref: Reactome:470350 "Conjugation of phenylacetate with glutamine"
xref: Reactome:470400 "Conjugation of salicylate with glycine"
xref: Reactome:487410 "Phase 1 - Functionalization of compounds"
xref: Reactome:487411 "Biological oxidations"
xref: Reactome:487415 "Phase II conjugation"
xref: Reactome:487594 "Phase 1 functionalization"
xref: Reactome:487713 "Conjugation of benzoate with glycine"
xref: Reactome:487714 "Conjugation of carboxylic acids"
xref: Reactome:487715 "Amino Acid conjugation"
xref: Reactome:488030 "Conjugation of phenylacetate with glutamine"
xref: Reactome:488078 "Conjugation of salicylate with glycine"
xref: Reactome:507362 "Phase 1 - Functionalization of compounds"
xref: Reactome:507363 "Biological oxidations"
xref: Reactome:507370 "Phase II conjugation"
xref: Reactome:507549 "Phase 1 functionalization"
xref: Reactome:517378 "Phase II conjugation"
xref: Reactome:517379 "Biological oxidations"
xref: Reactome:517417 "Phase 1 - Functionalization of compounds"
xref: Reactome:517528 "Phase 1 functionalization"
xref: Reactome:526254 "Phase II conjugation"
xref: Reactome:526255 "Biological oxidations"
xref: Reactome:526291 "Phase 1 - Functionalization of compounds"
xref: Reactome:526397 "Phase 1 functionalization"
xref: Reactome:531155 "Phase 1 - Functionalization of compounds"
xref: Reactome:531156 "Biological oxidations"
xref: Reactome:531211 "Phase 1 functionalization"
xref: Reactome:531414 "Phase II conjugation"
xref: Reactome:536526 "Phase 1 - Functionalization of compounds"
xref: Reactome:536527 "Biological oxidations"
xref: Reactome:536583 "Phase 1 functionalization"
xref: Reactome:536785 "Phase II conjugation"
xref: Reactome:542213 "Phase II conjugation"
xref: Reactome:542214 "Biological oxidations"
xref: Reactome:542229 "Phase 1 - Functionalization of compounds"
xref: Reactome:542246 "Phase 1 functionalization"
xref: Reactome:547567 "Phase II conjugation"
xref: Reactome:547568 "Biological oxidations"
xref: Reactome:547592 "Phase 1 - Functionalization of compounds"
xref: Reactome:547852 "Phase 1 functionalization"
xref: Reactome:552168 "Phase 1 - Functionalization of compounds"
xref: Reactome:552169 "Biological oxidations"
xref: Reactome:552242 "Phase 1 functionalization"
xref: Reactome:552443 "Phase II conjugation"
xref: Reactome:557761 "Phase II conjugation"
xref: Reactome:557762 "Biological oxidations"
xref: Reactome:557790 "Phase 1 - Functionalization of compounds"
xref: Reactome:557855 "Phase 1 functionalization"
xref: Reactome:568374 "Phase II conjugation"
xref: Reactome:568375 "Biological oxidations"
xref: Reactome:568403 "Phase 1 - Functionalization of compounds"
xref: Reactome:568449 "Phase 1 functionalization"
xref: Reactome:581576 "Phase II conjugation"
xref: Reactome:581577 "Biological oxidations"
xref: Reactome:581605 "Phase 1 - Functionalization of compounds"
xref: Reactome:581662 "Phase 1 functionalization"
xref: Reactome:586030 "Phase II conjugation"
xref: Reactome:586031 "Biological oxidations"
xref: Reactome:592501 "Phase 1 - Functionalization of compounds"
xref: Reactome:592502 "Biological oxidations"
xref: Reactome:592573 "Phase 1 functionalization"
xref: Reactome:592642 "Conjugation of benzoate with glycine"
xref: Reactome:592643 "Conjugation of carboxylic acids"
xref: Reactome:592644 "Amino Acid conjugation"
xref: Reactome:592645 "Phase II conjugation"
xref: Reactome:592861 "Conjugation of phenylacetate with glutamine"
xref: Reactome:592886 "Conjugation of salicylate with glycine"
xref: Reactome:595434 "Phase 1 - Functionalization of compounds"
xref: Reactome:595435 "Biological oxidations"
xref: Reactome:595529 "Phase II conjugation"
xref: Reactome:597324 "Phase 1 - Functionalization of compounds"
xref: Reactome:597325 "Biological oxidations"
xref: Reactome:597365 "Conjugation of benzoate with glycine"
xref: Reactome:597366 "Conjugation of carboxylic acids"
xref: Reactome:597367 "Amino Acid conjugation"
xref: Reactome:597368 "Phase II conjugation"
xref: Reactome:597439 "Conjugation of phenylacetate with glutamine"
xref: Reactome:597448 "Conjugation of salicylate with glycine"
xref: Reactome:598121 "Phase 1 - Functionalization of compounds"
xref: Reactome:598122 "Biological oxidations"
xref: Reactome:598212 "Phase II conjugation"
xref: Reactome:599669 "Phase 1 - Functionalization of compounds"
xref: Reactome:599670 "Biological oxidations"
xref: Reactome:599771 "Phase II conjugation"
xref: Reactome:600624 "Phase 1 - Functionalization of compounds"
xref: Reactome:600625 "Biological oxidations"
xref: Reactome:600690 "Phase II conjugation"
xref: Reactome:602454 "Phase II conjugation"
xref: Reactome:602455 "Biological oxidations"
xref: Reactome:602485 "Phase 1 - Functionalization of compounds"
xref: Reactome:602505 "Phase 1 functionalization"
xref: Wikipedia:Xenobiotic_metabolism
is_a: GO:0044237 ! cellular metabolic process
relationship: part_of GO:0071466 ! cellular response to xenobiotic stimulus

[Term]
id: GO:0006806
name: insecticide resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0017085

[Term]
id: GO:0006807
name: nitrogen compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [GOC:go_curators, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that amino acid and derivative metabolism should not be annotated here. Instead use the 'amino acid and derivative metabolism' node.
subset: goslim_pir
subset: gosubset_prok
synonym: "nitrogen compound metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0006808
name: regulation of nitrogen utilization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nitrogen utilization." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
relationship: regulates GO:0019740 ! nitrogen utilization

[Term]
id: GO:0006809
name: nitric oxide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai]
subset: gosubset_prok
synonym: "nitric oxide anabolism" EXACT []
synonym: "nitric oxide biosynthesis" EXACT []
synonym: "nitric oxide formation" EXACT []
synonym: "nitric oxide synthesis" EXACT []
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0046209 ! nitric oxide metabolic process

[Term]
id: GO:0006810
name: transport
namespace: biological_process
alt_id: GO:0015457
alt_id: GO:0015460
def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "auxiliary transport protein activity" RELATED [GOC:mah]
synonym: "small molecule transport" NARROW []
synonym: "solute:solute exchange" NARROW []
synonym: "transport accessory protein activity" RELATED [GOC:mah]
is_a: GO:0051234 ! establishment of localization

[Term]
id: GO:0006811
name: ion transport
namespace: biological_process
def: "The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0006812
name: cation transport
namespace: biological_process
alt_id: GO:0006819
def: "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006811 ! ion transport

[Term]
id: GO:0006813
name: potassium ion transport
namespace: biological_process
alt_id: GO:0015458
def: "The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "K+ conductance" EXACT []
synonym: "low voltage-dependent potassium channel auxiliary protein activity" RELATED [GOC:mah]
synonym: "low voltage-gated potassium channel auxiliary protein activity" RELATED [GOC:mah]
synonym: "potassium conductance" NARROW []
synonym: "potassium ion conductance" NARROW []
synonym: "potassium transport" EXACT []
synonym: "sodium/potassium transport" BROAD []
is_a: GO:0015672 ! monovalent inorganic cation transport
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0006814
name: sodium ion transport
namespace: biological_process
alt_id: GO:0006834
alt_id: GO:0016974
def: "The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "mitochondrial sodium/calcium ion exchange" NARROW []
synonym: "sodium channel auxiliary protein activity" RELATED [GOC:mah]
synonym: "sodium transport" EXACT []
synonym: "sodium/potassium transport" BROAD []
synonym: "sodium:calcium exchange" NARROW []
synonym: "sodium:solute transport" NARROW []
is_a: GO:0015672 ! monovalent inorganic cation transport
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0006815
name: sodium/potassium transport
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it is a composite term that represents two individual processes.
is_obsolete: true
consider: GO:0006813
consider: GO:0006814

[Term]
id: GO:0006816
name: calcium ion transport
namespace: biological_process
def: "The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "calcium transport" EXACT []
synonym: "mitochondrial sodium/calcium ion exchange" NARROW []
synonym: "sodium:calcium exchange" NARROW []
is_a: GO:0070838 ! divalent metal ion transport

[Term]
id: GO:0006817
name: phosphate transport
namespace: biological_process
def: "The directed movement of phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0006818
name: hydrogen transport
namespace: biological_process
def: "The directed movement of hydrogen (H2 or H+), into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0006820
name: anion transport
namespace: biological_process
alt_id: GO:0006822
def: "The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006811 ! ion transport

[Term]
id: GO:0006821
name: chloride transport
namespace: biological_process
def: "The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0006823
name: heavy metal ion transport
namespace: biological_process
def: "OBSOLETE. The directed movement of heavy metal ions into, out of, within or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
is_obsolete: true
consider: GO:0030001

[Term]
id: GO:0006824
name: cobalt ion transport
namespace: biological_process
def: "The directed movement of cobalt (Co) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "cobalt transport" EXACT []
is_a: GO:0000041 ! transition metal ion transport
is_a: GO:0015674 ! di-, tri-valent inorganic cation transport

[Term]
id: GO:0006825
name: copper ion transport
namespace: biological_process
def: "The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0006826
name: iron ion transport
namespace: biological_process
alt_id: GO:0015681
def: "The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "iron transport" EXACT []
is_a: GO:0000041 ! transition metal ion transport
is_a: GO:0015674 ! di-, tri-valent inorganic cation transport

[Term]
id: GO:0006827
name: high-affinity iron ion transport
namespace: biological_process
def: "The directed, high-affinity movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah]
subset: gosubset_prok
synonym: "high affinity iron ion transport" EXACT []
is_a: GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0006828
name: manganese ion transport
namespace: biological_process
def: "The directed movement of manganese (Mn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0006829
name: zinc ion transport
namespace: biological_process
def: "The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "zinc transport" EXACT [GOC:mah]
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0006830
name: high-affinity zinc ion transport
namespace: biological_process
def: "The directed, high-affinity movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah]
is_a: GO:0071577 ! zinc ion transmembrane transport

[Term]
id: GO:0006831
name: low-affinity zinc ion transport
namespace: biological_process
def: "The directed, low-affinity movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah]
is_a: GO:0071577 ! zinc ion transmembrane transport

[Term]
id: GO:0006832
name: small molecule transport
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0006810

[Term]
id: GO:0006833
name: water transport
namespace: biological_process
def: "The directed movement of water (H2O) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0042044 ! fluid transport

[Term]
id: GO:0006835
name: dicarboxylic acid transport
namespace: biological_process
alt_id: GO:0006841
def: "The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
synonym: "sodium:dicarboxylate transport" RELATED []
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0006836
name: neurotransmitter transport
namespace: biological_process
def: "The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai]
subset: goslim_pir
synonym: "sodium:neurotransmitter transport" NARROW []
is_a: GO:0006810 ! transport

[Term]
id: GO:0006837
name: serotonin transport
namespace: biological_process
def: "The directed movement of serotonin into, out of, within or between cells by means of some external agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
is_a: GO:0015844 ! monoamine transport

[Term]
id: GO:0006838
name: allantoin/allantoate transport
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it is a composite term that represents two individual processes.
is_obsolete: true
consider: GO:0015719
consider: GO:0015720

[Term]
id: GO:0006839
name: mitochondrial transport
namespace: biological_process
def: "Transport of substances into, out of or within a mitochondrion." [GOC:ai]
synonym: "mitochondrial alpha-ketoglutarate/malate transport" NARROW []
synonym: "mitochondrial aspartate/glutamate transport" NARROW []
synonym: "mitochondrial sodium/calcium ion exchange" NARROW []
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0006840
name: mitochondrial alpha-ketoglutarate/malate transport
namespace: biological_process
def: "OBSOLETE. The directed movement of alpha-ketoglutarate and malate into, out of or within a mitochondrion." [GOC:ai]
comment: This term was made obsolete because it represents a function rather than a process.
synonym: "mitochondrial oxoglutarate/malate transport" EXACT []
is_obsolete: true
replaced_by: GO:0006839
replaced_by: GO:0015367
replaced_by: GO:0015742
replaced_by: GO:0015743

[Term]
id: GO:0006842
name: tricarboxylic acid transport
namespace: biological_process
def: "The directed movement of tricarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0006843
name: mitochondrial citrate transport
namespace: biological_process
def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a mitochondrion." [GOC:ai]
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0015746 ! citrate transport

[Term]
id: GO:0006844
name: acyl carnitine transport
namespace: biological_process
def: "The directed movement of acyl carnitine into, out of, within or between cells by means of some external agent such as a transporter or pore. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai]
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0006845
name: mitochondrial aspartate/glutamate transport
namespace: biological_process
def: "OBSOLETE. The directed movement of aspartate and glutamate into, out of or within a mitochondrion." [GOC:ai]
comment: This term was made obsolete because it represents a function rather than a process.
is_obsolete: true
replaced_by: GO:0006839
replaced_by: GO:0015810
replaced_by: GO:0015813

[Term]
id: GO:0006846
name: acetate transport
namespace: biological_process
def: "The directed movement of acetate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0006847
name: plasma membrane acetate transport
namespace: biological_process
def: "The directed movement of acetate across a plasma membrane." [GOC:ai]
is_a: GO:0006846 ! acetate transport

[Term]
id: GO:0006848
name: pyruvate transport
namespace: biological_process
def: "The directed movement of pyruvate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0006849
name: plasma membrane pyruvate transport
namespace: biological_process
def: "The directed movement of pyruvate, 2-oxopropanoate, across a plasma membrane." [GOC:ai]
is_a: GO:0006848 ! pyruvate transport

[Term]
id: GO:0006850
name: mitochondrial pyruvate transport
namespace: biological_process
def: "The directed movement of pyruvate, 2-oxopropanoate, into, out of or within a mitochondrion." [GOC:ai]
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0006848 ! pyruvate transport

[Term]
id: GO:0006851
name: mitochondrial calcium ion transport
namespace: biological_process
def: "The directed movement of calcium ions (Ca2+) into, out of or within a mitochondrion." [GOC:ai]
synonym: "mitochondrial calcium transport" EXACT []
is_a: GO:0006816 ! calcium ion transport
is_a: GO:0006839 ! mitochondrial transport

[Term]
id: GO:0006852
name: mitochondrial sodium/calcium ion exchange
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents function rather than a process.
synonym: "mitochondrial sodium/calcium exchange" EXACT []
is_obsolete: true
replaced_by: GO:0006814
replaced_by: GO:0006816
replaced_by: GO:0006839
consider: GO:0005432

[Term]
id: GO:0006853
name: carnitine shuttle
namespace: biological_process
def: "The transfer of acyl groups to and from acyl-CoA molecules to form O-acylcarnitine, which can exchange across the mitochondrial inner membrane with unacylated carnitine." [ISBN:0198547684]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
xref: Reactome:200425 "Import of palmitoyl-CoA into the mitochondrial matrix"
xref: Reactome:448992 "Import of palmitoyl-CoA into the mitochondrial matrix"
xref: Reactome:470106 "Import of palmitoyl-CoA into the mitochondrial matrix"
xref: Reactome:487804 "Import of palmitoyl-CoA into the mitochondrial matrix"
xref: Reactome:507766 "Import of palmitoyl-CoA into the mitochondrial matrix"
xref: Reactome:517686 "Import of palmitoyl-CoA into the mitochondrial matrix"
xref: Reactome:526523 "Import of palmitoyl-CoA into the mitochondrial matrix"
xref: Reactome:531321 "Import of palmitoyl-CoA into the mitochondrial matrix"
xref: Reactome:536704 "Import of palmitoyl-CoA into the mitochondrial matrix"
xref: Reactome:542440 "Import of palmitoyl-CoA into the mitochondrial matrix"
xref: Reactome:547966 "Import of palmitoyl-CoA into the mitochondrial matrix"
xref: Reactome:557951 "Import of palmitoyl-CoA into the mitochondrial matrix"
xref: Reactome:568793 "Import of palmitoyl-CoA into the mitochondrial matrix"
xref: Reactome:581996 "Import of palmitoyl-CoA into the mitochondrial matrix"
xref: Reactome:592904 "Import of palmitoyl-CoA into the mitochondrial matrix"
xref: Wikipedia:Carnitine#Role_in_fatty_acid_metabolism
is_a: GO:0003333 ! amino acid transmembrane transport
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0015879 ! carnitine transport
is_a: GO:0015909 ! long-chain fatty acid transport
is_a: GO:0032365 ! intracellular lipid transport

[Term]
id: GO:0006854
name: ATP/ADP exchange
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
is_obsolete: true
replaced_by: GO:0005471

[Term]
id: GO:0006855
name: multidrug transport
namespace: biological_process
def: "The directed movement of drugs across a membrane into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015893 ! drug transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0006856
name: eye pigment precursor transport
namespace: biological_process
def: "The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0006810 ! transport
relationship: part_of GO:0048066 ! pigmentation during development

[Term]
id: GO:0006857
name: oligopeptide transport
namespace: biological_process
def: "The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015833 ! peptide transport

[Term]
id: GO:0006858
name: extracellular transport
namespace: biological_process
def: "The transport of substances that occurs outside cells." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0006859
name: extracellular carbohydrate transport
namespace: biological_process
def: "The directed extracellular movement of carbohydrates." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006858 ! extracellular transport
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0006860
name: extracellular amino acid transport
namespace: biological_process
def: "The directed extracellular movement of amino acids." [GOC:ai]
is_a: GO:0006858 ! extracellular transport
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0006862
name: nucleotide transport
namespace: biological_process
def: "The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport

[Term]
id: GO:0006863
name: purine transport
namespace: biological_process
alt_id: GO:0015852
def: "The directed movement of purines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of, within or between cells by means of some external agent such as a transporter or pore." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015851 ! nucleobase transport

[Term]
id: GO:0006864
name: pyrimidine nucleotide transport
namespace: biological_process
def: "The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai]
is_a: GO:0006862 ! nucleotide transport

[Term]
id: GO:0006865
name: amino acid transport
namespace: biological_process
alt_id: GO:0006866
def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
xref: Reactome:352230 "Amino acid transport across the plasma membrane"
xref: Reactome:449281 "Amino acid transport across the plasma membrane"
xref: Reactome:470401 "Amino acid transport across the plasma membrane"
xref: Reactome:488079 "Amino acid transport across the plasma membrane"
xref: Reactome:508045 "Amino acid transport across the plasma membrane"
xref: Reactome:517899 "Amino acid transport across the plasma membrane"
xref: Reactome:526725 "Amino acid transport across the plasma membrane"
xref: Reactome:531498 "Amino acid transport across the plasma membrane"
xref: Reactome:536887 "Amino acid transport across the plasma membrane"
xref: Reactome:542637 "Amino acid transport across the plasma membrane"
xref: Reactome:547953 "Amino acid transport across the plasma membrane"
xref: Reactome:552527 "Amino acid transport across the plasma membrane"
xref: Reactome:558149 "Amino acid transport across the plasma membrane"
xref: Reactome:568776 "Amino acid transport across the plasma membrane"
xref: Reactome:581979 "Amino acid transport across the plasma membrane"
xref: Reactome:586032 "Amino acid transport across the plasma membrane"
xref: Reactome:592887 "Amino acid transport across the plasma membrane"
xref: Reactome:597449 "Amino acid transport across the plasma membrane"
xref: Reactome:598213 "Amino acid transport across the plasma membrane"
xref: Reactome:599782 "Amino acid transport across the plasma membrane"
xref: Reactome:602616 "Amino acid transport across the plasma membrane"
is_a: GO:0015837 ! amine transport
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0006867
name: asparagine transport
namespace: biological_process
def: "The directed movement of asparagine, alpha-aminosuccinamic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-asparagine transport" NARROW []
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0006868
name: glutamine transport
namespace: biological_process
alt_id: GO:0015815
def: "The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-glutamine transport" NARROW []
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0006869
name: lipid transport
namespace: biological_process
def: "The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
xref: Reactome:383186 "lipid transport"
is_a: GO:0006810 ! transport
relationship: part_of GO:0010876 ! lipid localization

[Term]
id: GO:0006873
name: cellular ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of ions at the level of a cell." [GOC:mah]
subset: gosubset_prok
is_a: GO:0050801 ! ion homeostasis
is_a: GO:0055082 ! cellular chemical homeostasis

[Term]
id: GO:0006874
name: cellular calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of calcium ions at the level of a cell." [GOC:ceb, GOC:mah]
synonym: "regulation of calcium ion concentration" BROAD []
is_a: GO:0006875 ! cellular metal ion homeostasis
is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis
is_a: GO:0055074 ! calcium ion homeostasis

[Term]
id: GO:0006875
name: cellular metal ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of metal ions at the level of a cell." [GOC:ai, GOC:mah]
subset: gosubset_prok
synonym: "cellular heavy metal ion homeostasis" NARROW []
is_a: GO:0030003 ! cellular cation homeostasis
is_a: GO:0055065 ! metal ion homeostasis

[Term]
id: GO:0006876
name: cellular cadmium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of cadmium ions at the level of a cell." [GOC:ai, GOC:mah]
synonym: "cadmium homeostasis" BROAD []
is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis
is_a: GO:0046916 ! cellular transition metal ion homeostasis
is_a: GO:0055073 ! cadmium ion homeostasis

[Term]
id: GO:0006877
name: cellular cobalt ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of cobalt ions at the level of a cell." [GOC:ai, GOC:mah]
synonym: "cobalt homeostasis" BROAD []
is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis
is_a: GO:0055068 ! cobalt ion homeostasis

[Term]
id: GO:0006878
name: cellular copper ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of copper ions at the level of a cell." [GOC:ai, GOC:mah]
subset: gosubset_prok
synonym: "copper homeostasis" BROAD []
is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis
is_a: GO:0055070 ! copper ion homeostasis

[Term]
id: GO:0006879
name: cellular iron ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of iron ions at the level of a cell." [GOC:ai, GOC:mah]
subset: gosubset_prok
synonym: "iron homeostasis" BROAD []
is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis
is_a: GO:0055072 ! iron ion homeostasis

[Term]
id: GO:0006880
name: intracellular sequestering of iron ion
namespace: biological_process
def: "The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system." [GOC:ai]
subset: gosubset_prok
synonym: "intracellular iron ion retention" EXACT []
synonym: "intracellular iron ion sequestering" EXACT []
synonym: "intracellular iron ion sequestration" EXACT []
synonym: "intracellular iron ion storage" EXACT []
synonym: "intracellular retention of iron ion" EXACT []
synonym: "intracellular sequestration of iron ion" EXACT []
synonym: "intracellular storage of iron ion" EXACT []
is_a: GO:0051238 ! sequestering of metal ion
is_a: GO:0051651 ! maintenance of location in cell
relationship: part_of GO:0006879 ! cellular iron ion homeostasis

[Term]
id: GO:0006881
name: extracellular sequestering of iron ion
namespace: biological_process
def: "The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system." [GOC:ai]
synonym: "extracellular iron ion retention" EXACT []
synonym: "extracellular iron ion sequestering" EXACT []
synonym: "extracellular iron ion sequestration" EXACT []
synonym: "extracellular iron ion storage" EXACT []
synonym: "extracellular retention of iron ion" EXACT []
synonym: "extracellular sequestration of iron ion" EXACT []
synonym: "extracellular storage of iron ion" EXACT []
is_a: GO:0051238 ! sequestering of metal ion
relationship: part_of GO:0033212 ! iron assimilation

[Term]
id: GO:0006882
name: cellular zinc ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of zinc ions at the level of a cell." [GOC:ai, GOC:mah]
synonym: "zinc homeostasis" BROAD []
is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis
is_a: GO:0055069 ! zinc ion homeostasis

[Term]
id: GO:0006883
name: cellular sodium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of sodium ions at the level of a cell." [GOC:ai, GOC:mah]
is_a: GO:0006875 ! cellular metal ion homeostasis
is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis
is_a: GO:0055078 ! sodium ion homeostasis

[Term]
id: GO:0006884
name: cell volume homeostasis
namespace: biological_process
def: "Any process involved in maintaining the equilibrium of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb]
subset: gosubset_prok
synonym: "regulation of cell volume" EXACT [GOC:dph, GOC:tb]
is_a: GO:0019725 ! cellular homeostasis

[Term]
id: GO:0006885
name: regulation of pH
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb]
subset: gosubset_prok
synonym: "hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0055067 ! monovalent inorganic cation homeostasis

[Term]
id: GO:0006886
name: intracellular protein transport
namespace: biological_process
def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah]
subset: gosubset_prok
is_a: GO:0015031 ! protein transport
is_a: GO:0046907 ! intracellular transport
relationship: part_of GO:0034613 ! cellular protein localization

[Term]
id: GO:0006887
name: exocytosis
namespace: biological_process
alt_id: GO:0016194
alt_id: GO:0016195
def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363]
subset: gosubset_prok
synonym: "nonselective vesicle exocytosis" RELATED []
synonym: "vesicle exocytosis" EXACT []
xref: Wikipedia:Exocytosis
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0006888
name: ER to Golgi vesicle-mediated transport
namespace: biological_process
alt_id: GO:0048221
def: "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jpark, GOC:tb, ISBN:0716731363]
synonym: "endoplasmic reticulum to Golgi transport" EXACT []
synonym: "endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT []
synonym: "ER to Golgi transport" EXACT []
synonym: "rough endoplasmic reticulum to cis-Golgi transport" EXACT []
synonym: "rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT []
synonym: "rough ER to cis-Golgi transport" EXACT []
synonym: "rough ER to cis-Golgi vesicle-mediated transport" EXACT []
xref: Reactome:159763 "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"
xref: Reactome:199977 "ER to Golgi Transport"
xref: Reactome:448950 "ER to Golgi Transport"
xref: Reactome:449261 "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"
xref: Reactome:470069 "ER to Golgi Transport"
xref: Reactome:470380 "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"
xref: Reactome:487762 "ER to Golgi Transport"
xref: Reactome:488062 "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"
xref: Reactome:507726 "ER to Golgi Transport"
xref: Reactome:508019 "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"
xref: Reactome:517658 "ER to Golgi Transport"
xref: Reactome:517880 "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus"
xref: Reactome:526491 "ER to Golgi Transport"
xref: Reactome:531306 "ER to Golgi Transport"
xref: Reactome:536680 "ER to Golgi Transport"
xref: Reactome:542413 "ER to Golgi Transport"
xref: Reactome:547762 "ER to Golgi Transport"
xref: Reactome:552333 "ER to Golgi Transport"
xref: Reactome:557938 "ER to Golgi Transport"
xref: Reactome:568565 "ER to Golgi Transport"
xref: Reactome:581769 "ER to Golgi Transport"
xref: Reactome:585887 "ER to Golgi Transport"
xref: Reactome:592688 "ER to Golgi Transport"
xref: Reactome:595445 "ER to Golgi Transport"
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0006889
name: regulation of calcium in ER
namespace: biological_process
def: "OBSOLETE. Any process that modulates the concentration of calcium in the endoplasmic reticulum." [GOC:go_curators]
comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport').
is_obsolete: true
consider: GO:0005783
consider: GO:0006874

[Term]
id: GO:0006890
name: retrograde vesicle-mediated transport, Golgi to ER
namespace: biological_process
def: "The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524]
synonym: "retrograde (Golgi to ER) transport" EXACT []
synonym: "retrograde transport, Golgi to endoplasmic reticulum" EXACT []
synonym: "retrograde transport, Golgi to ER" EXACT []
synonym: "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" RELATED []
xref: Reactome:199983 "Golgi to ER Retrograde Transport"
xref: Reactome:448814 "Golgi to ER Retrograde Transport"
xref: Reactome:469930 "Golgi to ER Retrograde Transport"
xref: Reactome:487633 "Golgi to ER Retrograde Transport"
xref: Reactome:507592 "Golgi to ER Retrograde Transport"
xref: Reactome:517560 "Golgi to ER Retrograde Transport"
xref: Reactome:526426 "Golgi to ER Retrograde Transport"
xref: Reactome:531243 "Golgi to ER Retrograde Transport"
xref: Reactome:536614 "Golgi to ER Retrograde Transport"
xref: Reactome:542338 "Golgi to ER Retrograde Transport"
xref: Reactome:547679 "Golgi to ER Retrograde Transport"
xref: Reactome:552341 "Golgi to ER Retrograde Transport"
xref: Reactome:557888 "Golgi to ER Retrograde Transport"
xref: Reactome:568486 "Golgi to ER Retrograde Transport"
xref: Reactome:581697 "Golgi to ER Retrograde Transport"
xref: Reactome:585897 "Golgi to ER Retrograde Transport"
xref: Reactome:592604 "Golgi to ER Retrograde Transport"
xref: Reactome:595453 "Golgi to ER Retrograde Transport"
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0006891
name: intra-Golgi vesicle-mediated transport
namespace: biological_process
def: "The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363]
synonym: "intra-Golgi transport" EXACT []
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0006892
name: post-Golgi vesicle-mediated transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah]
synonym: "post-Golgi transport" EXACT []
xref: Reactome:199992 "trans-Golgi Network Vesicle Budding"
xref: Reactome:449297 "trans-Golgi Network Vesicle Budding"
xref: Reactome:470417 "trans-Golgi Network Vesicle Budding"
xref: Reactome:488094 "trans-Golgi Network Vesicle Budding"
xref: Reactome:508064 "trans-Golgi Network Vesicle Budding"
xref: Reactome:517913 "trans-Golgi Network Vesicle Budding"
xref: Reactome:526742 "trans-Golgi Network Vesicle Budding"
xref: Reactome:531505 "trans-Golgi Network Vesicle Budding"
xref: Reactome:536896 "trans-Golgi Network Vesicle Budding"
xref: Reactome:542644 "trans-Golgi Network Vesicle Budding"
xref: Reactome:547959 "trans-Golgi Network Vesicle Budding"
xref: Reactome:558157 "trans-Golgi Network Vesicle Budding"
xref: Reactome:568786 "trans-Golgi Network Vesicle Budding"
xref: Reactome:581989 "trans-Golgi Network Vesicle Budding"
xref: Reactome:586046 "trans-Golgi Network Vesicle Budding"
xref: Reactome:592896 "trans-Golgi Network Vesicle Budding"
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0006893
name: Golgi to plasma membrane transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363]
synonym: "Golgi to plasma membrane vesicle-mediated transport" EXACT []
is_a: GO:0006892 ! post-Golgi vesicle-mediated transport

[Term]
id: GO:0006894
name: Golgi to secretory vesicle transport
namespace: biological_process
def: "OBSOLETE. The directed movement of proteins from the Golgi to one of two types of secretory vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. Specialized secretory cells have a second secretory pathway in which soluble proteins and other substances are initially stored in secretory vesicles for later release." [ISBN:0716731363]
comment: This term was made obsolete because it mixes two processes that can be better captured in separate terms.
synonym: "Golgi to secretory vesicle transport, vesicle-mediated" EXACT []
is_obsolete: true
consider: GO:0055107
consider: GO:0055108

[Term]
id: GO:0006895
name: Golgi to endosome transport
namespace: biological_process
alt_id: GO:0048218
def: "The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes." [GOC:jl, ISBN:0716731363, PMID:10873832]
synonym: "Golgi to endosome vesicle-mediated transport" EXACT []
synonym: "TGN to endosome transport" EXACT []
synonym: "trans-Golgi to endosome transport" EXACT []
is_a: GO:0006892 ! post-Golgi vesicle-mediated transport
is_a: GO:0016197 ! endosome transport

[Term]
id: GO:0006896
name: Golgi to vacuole transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to the vacuole." [GOC:ai]
synonym: "Golgi to vacuole vesicle-mediated transport" EXACT []
is_a: GO:0006892 ! post-Golgi vesicle-mediated transport
is_a: GO:0007034 ! vacuolar transport

[Term]
id: GO:0006897
name: endocytosis
namespace: biological_process
alt_id: GO:0016193
alt_id: GO:0016196
def: "A type of vesicle-mediated transport in which cells take up external materials or membrane constituents by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363]
subset: gosubset_prok
synonym: "nonselective vesicle endocytosis" RELATED []
synonym: "plasma membrane invagination" EXACT []
synonym: "vesicle endocytosis" EXACT []
xref: Wikipedia:Endocytosis
is_a: GO:0010324 ! membrane invagination
is_a: GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0006898
name: receptor-mediated endocytosis
namespace: biological_process
def: "The uptake of external materials by cells, utilizing receptors to ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [ISBN:0716731363]
synonym: "receptor mediated endocytosis" EXACT []
xref: Reactome:171052 "LDL endocytosis"
xref: Reactome:171059 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]"
xref: Reactome:171087 "LDLR [endosome membrane] => LDLR [plasma membrane]"
xref: Reactome:171106 "LDLR:LDL complex => LDLR + LDL"
xref: Reactome:171118 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)"
xref: Reactome:171122 "LDL + LDLR => LDL:LDLR complex"
xref: Reactome:171141 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)"
xref: Reactome:174624 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR"
xref: Reactome:174657 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex"
xref: Reactome:174808 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]"
xref: Reactome:434494 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex"
xref: Reactome:434521 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR"
xref: Reactome:434537 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]"
xref: Reactome:441755 "LDL + LDLR => LDL:LDLR complex"
xref: Reactome:441764 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)"
xref: Reactome:441766 "LDLR [endosome membrane] => LDLR [plasma membrane]"
xref: Reactome:441782 "LDLR:LDL complex => LDLR + LDL"
xref: Reactome:441783 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]"
xref: Reactome:449175 "LDL endocytosis"
xref: Reactome:456974 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex"
xref: Reactome:456991 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR"
xref: Reactome:457002 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]"
xref: Reactome:463488 "LDL + LDLR => LDL:LDLR complex"
xref: Reactome:463492 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)"
xref: Reactome:463494 "LDLR [endosome membrane] => LDLR [plasma membrane]"
xref: Reactome:463500 "LDLR:LDL complex => LDLR + LDL"
xref: Reactome:463501 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]"
xref: Reactome:470288 "LDL endocytosis"
xref: Reactome:482074 "LDL + LDLR => LDL:LDLR complex"
xref: Reactome:482083 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)"
xref: Reactome:482088 "LDLR [endosome membrane] => LDLR [plasma membrane]"
xref: Reactome:482094 "LDLR:LDL complex => LDLR + LDL"
xref: Reactome:482095 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]"
xref: Reactome:487964 "LDL endocytosis"
xref: Reactome:496026 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex"
xref: Reactome:496048 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR"
xref: Reactome:496062 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]"
xref: Reactome:502263 "LDL + LDLR => LDL:LDLR complex"
xref: Reactome:502269 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)"
xref: Reactome:502271 "LDLR [endosome membrane] => LDLR [plasma membrane]"
xref: Reactome:502281 "LDLR:LDL complex => LDLR + LDL"
xref: Reactome:502282 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]"
xref: Reactome:507939 "LDL endocytosis"
xref: Reactome:514719 "LDL + LDLR => LDL:LDLR complex"
xref: Reactome:514726 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)"
xref: Reactome:514730 "LDLR [endosome membrane] => LDLR [plasma membrane]"
xref: Reactome:514736 "LDLR:LDL complex => LDLR + LDL"
xref: Reactome:514737 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]"
xref: Reactome:517810 "LDL endocytosis"
xref: Reactome:523782 "LDLR [endosome membrane] => LDLR [plasma membrane]"
xref: Reactome:526642 "LDL endocytosis"
xref: Wikipedia:Receptor-mediated_endocytosis
is_a: GO:0006897 ! endocytosis

[Term]
id: GO:0006900
name: membrane budding
namespace: biological_process
alt_id: GO:0006902
def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jic, GOC:tb]
synonym: "membrane evagination" EXACT []
synonym: "nonselective vesicle assembly" RELATED []
synonym: "vesicle biosynthesis" EXACT []
synonym: "vesicle budding" RELATED []
synonym: "vesicle formation" EXACT []
is_a: GO:0016044 ! cellular membrane organization
is_a: GO:0016050 ! vesicle organization
relationship: part_of GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0006901
name: vesicle coating
namespace: biological_process
def: "A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jic]
synonym: "vesicle coat assembly" BROAD []
is_a: GO:0016050 ! vesicle organization
relationship: part_of GO:0006900 ! membrane budding

[Term]
id: GO:0006903
name: vesicle targeting
namespace: biological_process
def: "The process by which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816]
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0016192 ! vesicle-mediated transport
relationship: part_of GO:0051650 ! establishment of vesicle localization

[Term]
id: GO:0006904
name: vesicle docking during exocytosis
namespace: biological_process
def: "The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, during exocytosis." [GOC:jic]
subset: gosubset_prok
is_a: GO:0048278 ! vesicle docking
relationship: part_of GO:0006887 ! exocytosis

[Term]
id: GO:0006905
name: vesicle transport
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the meaning of the term is ambiguous.
is_obsolete: true
consider: GO:0016192

[Term]
id: GO:0006906
name: vesicle fusion
namespace: biological_process
def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jic]
is_a: GO:0006944 ! cellular membrane fusion
is_a: GO:0016050 ! vesicle organization
is_a: GO:0048284 ! organelle fusion
relationship: part_of GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0006907
name: pinocytosis
namespace: biological_process
def: "The process whereby cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "fluid-phase endocytosis" EXACT []
xref: Wikipedia:Pinocytosis
is_a: GO:0006897 ! endocytosis

[Term]
id: GO:0006908
name: clathrin-independent pinocytosis
namespace: biological_process
is_a: GO:0006907 ! pinocytosis

[Term]
id: GO:0006909
name: phagocytosis
namespace: biological_process
def: "The process whereby phagocytes engulf external particulate material. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: Wikipedia:Phagocytosis
is_a: GO:0006897 ! endocytosis

[Term]
id: GO:0006910
name: phagocytosis, recognition
namespace: biological_process
def: "The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell." [GOC:curators, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that cell surface molecules involved in the direct binding of bacteria may be also annotated to the molecular function term GO:0008367 bacterial binding. Note that cell surface molecules involved in the direct binding to opsonins such as complement components or antibodies may be also annotated to the term GO:0001846 opsonin binding.
synonym: "recognition of phagocytosed substance by phagocytic cell" EXACT []
is_a: GO:0008037 ! cell recognition
relationship: part_of GO:0006909 ! phagocytosis

[Term]
id: GO:0006911
name: phagocytosis, engulfment
namespace: biological_process
def: "The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149 "Fundamental Immunology"]
synonym: "phagosome biosynthesis" RELATED []
synonym: "phagosome formation" RELATED []
is_a: GO:0010324 ! membrane invagination
relationship: part_of GO:0006909 ! phagocytosis

[Term]
id: GO:0006912
name: phagosome formation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd]
comment: This term was made obsolete because of the ambiguity in its meaning.
is_obsolete: true
consider: GO:0001845
consider: GO:0006911

[Term]
id: GO:0006913
name: nucleocytoplasmic transport
namespace: biological_process
alt_id: GO:0000063
def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators]
subset: goslim_pombe
synonym: "nucleocytoplasmic shuttling" NARROW []
is_a: GO:0051169 ! nuclear transport

[Term]
id: GO:0006914
name: autophagy
namespace: biological_process
def: "The process by which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [ISBN:0198547684, PMID:11099404, PMID:9412464]
subset: goslim_pir
xref: Wikipedia:Autophagy_(cellular)
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0006915
name: apoptosis
namespace: biological_process
alt_id: GO:0008632
def: "A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:18846107]
synonym: "apoptotic cell death" EXACT [GOC:sl]
synonym: "apoptotic program" NARROW [GOC:add]
synonym: "apoptotic programmed cell death" EXACT []
synonym: "programmed cell death by apoptosis" EXACT []
synonym: "signaling (initiator) caspase activity" RELATED []
synonym: "type I programmed cell death" NARROW []
xref: Reactome:109581 "Apoptosis"
xref: Reactome:193648 "NRAGE signals death through JNK"
xref: Reactome:205025 "NADE modulates death signalling"
xref: Reactome:205043 "NRIF signals cell death from the nucleus"
xref: Reactome:448508 "NADE modulates death signalling"
xref: Reactome:448611 "NRAGE signals death through JNK"
xref: Reactome:448685 "Apoptosis"
xref: Reactome:449127 "NRIF signals cell death from the nucleus"
xref: Reactome:469638 "NADE modulates death signalling"
xref: Reactome:469739 "NRAGE signals death through JNK"
xref: Reactome:469808 "Apoptosis"
xref: Reactome:470237 "NRIF signals cell death from the nucleus"
xref: Reactome:487550 "NRAGE signals death through JNK"
xref: Reactome:487666 "Apoptosis"
xref: Reactome:487920 "NRIF signals cell death from the nucleus"
xref: Reactome:507462 "Apoptosis"
xref: Reactome:507506 "NRAGE signals death through JNK"
xref: Reactome:507977 "NRIF signals cell death from the nucleus"
xref: Reactome:517491 "NRAGE signals death through JNK"
xref: Reactome:517584 "Apoptosis"
xref: Reactome:526360 "NRAGE signals death through JNK"
xref: Reactome:526461 "Apoptosis"
xref: Reactome:531265 "Apoptosis"
xref: Reactome:536644 "Apoptosis"
xref: Reactome:542372 "Apoptosis"
xref: Reactome:547717 "Apoptosis"
xref: Reactome:552296 "Apoptosis"
xref: Reactome:558146 "Apoptosis"
xref: Reactome:568771 "Apoptosis"
xref: Reactome:581974 "Apoptosis"
xref: Reactome:585866 "Apoptosis"
xref: Reactome:592641 "Apoptosis"
xref: Reactome:595585 "Apoptosis"
xref: Wikipedia:Apoptosis
is_a: GO:0012501 ! programmed cell death

[Term]
id: GO:0006916
name: anti-apoptosis
namespace: biological_process
def: "A process which directly inhibits any of the steps required for cell death by apoptosis." [GOC:go_curators]
synonym: "apoptosis inhibitor activity" RELATED []
xref: Reactome:193639 "p75NTR signals via NF-kB"
xref: Reactome:449150 "p75NTR signals via NF-kB"
xref: Reactome:470264 "p75NTR signals via NF-kB"
xref: Reactome:487943 "p75NTR signals via NF-kB"
xref: Reactome:507914 "p75NTR signals via NF-kB"
xref: Reactome:517798 "p75NTR signals via NF-kB"
is_a: GO:0043066 ! negative regulation of apoptosis

[Term]
id: GO:0006917
name: induction of apoptosis
namespace: biological_process
def: "A process that directly activates any of the steps required for cell death by apoptosis." [GOC:go_curators]
synonym: "activation of apoptosis" EXACT []
synonym: "apoptosis activator activity" RELATED []
synonym: "apoptosis signaling" BROAD []
synonym: "commitment to apoptosis" EXACT []
synonym: "induction of apoptosis by p53" NARROW []
is_a: GO:0012502 ! induction of programmed cell death
is_a: GO:0043065 ! positive regulation of apoptosis

[Term]
id: GO:0006918
name: induction of apoptosis by p53
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more accurate terms were created.
is_obsolete: true
consider: GO:0006917

[Term]
id: GO:0006919
name: activation of caspase activity
namespace: biological_process
def: "Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:dph, GOC:jl, GOC:tb, Wikipedia:Caspase]
synonym: "caspase activation" EXACT [GOC:dph, GOC:tb]
xref: Reactome:449093 "Activation of Pro-Caspase 8"
xref: Reactome:470205 "Activation of Pro-Caspase 8"
xref: Reactome:487892 "Activation of Pro-Caspase 8"
xref: Reactome:508060 "Activation of Pro-Caspase 8"
xref: Reactome:69416 "Activation of Pro-Caspase 8"
xref: Reactome:75142 "Activation of Effector Caspases"
is_a: GO:0043280 ! positive regulation of caspase activity
relationship: part_of GO:0006915 ! apoptosis

[Term]
id: GO:0006920
name: commitment to apoptosis
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more accurate terms were created.
is_obsolete: true
consider: GO:0006917

[Term]
id: GO:0006921
name: cell structure disassembly during apoptosis
namespace: biological_process
def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:mah]
synonym: "disassembly of cell structures" BROAD []
xref: Reactome:448841 "Apoptotic execution phase"
xref: Reactome:469957 "Apoptotic execution phase"
xref: Reactome:487665 "Apoptotic execution phase"
xref: Reactome:507618 "Apoptotic execution phase"
xref: Reactome:517583 "Apoptotic execution phase"
xref: Reactome:526460 "Apoptotic execution phase"
xref: Reactome:531264 "Apoptotic execution phase"
xref: Reactome:536643 "Apoptotic execution phase"
xref: Reactome:542371 "Apoptotic execution phase"
xref: Reactome:547716 "Apoptotic execution phase"
xref: Reactome:552295 "Apoptotic execution phase"
xref: Reactome:585865 "Apoptotic execution phase"
xref: Reactome:592640 "Apoptotic execution phase"
xref: Reactome:75153 "Apoptotic execution phase"
is_a: GO:0022411 ! cellular component disassembly
relationship: part_of GO:0006915 ! apoptosis

[Term]
id: GO:0006922
name: cleavage of lamin
namespace: biological_process
def: "The proteolytic degradation of lamins during apoptosis, leading to the irreversible breakdown of the nuclear lamina." [GOC:mah, ISBN:0815332181]
is_a: GO:0006923 ! cleavage of cytoskeletal proteins during apoptosis

[Term]
id: GO:0006923
name: cleavage of cytoskeletal proteins during apoptosis
namespace: biological_process
def: "The proteolytic degradation of cytoskeletal proteins during apoptosis, leading to the collapse of cytoskeletal structures." [GOC:mah, ISBN:0815332181]
synonym: "apoptotic cleavage of cytoskeletal proteins" EXACT []
is_a: GO:0006921 ! cell structure disassembly during apoptosis

[Term]
id: GO:0006924
name: activation-induced cell death of T cells
namespace: biological_process
def: "A type of T cell apoptosis that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors." [GOC:add, ISBN:0781765196, PMID:12414721, PMID:12752672]
synonym: "activated T cell apoptosis" BROAD [GOC:add]
synonym: "activation-induced cell death of T lymphocytes" EXACT [GOC:add]
synonym: "activation-induced cell death of T-cells" EXACT [GOC:add]
synonym: "activation-induced cell death of T-lymphocytes" EXACT [GOC:add]
synonym: "AICD" BROAD [GOC:add]
synonym: "antigen-driven apoptosis" BROAD [GOC:add]
is_a: GO:0070231 ! T cell apoptosis
relationship: part_of GO:0043029 ! T cell homeostasis

[Term]
id: GO:0006925
name: inflammatory cell apoptosis
namespace: biological_process
def: "The process of apoptosis in inflammatory cells, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, http://www.mercksource.com/]
synonym: "apoptosis of inflammatory cells" EXACT []
synonym: "inflammatory cell programmed cell death by apoptosis" EXACT []
synonym: "killing of inflammatory cells" EXACT []
synonym: "programmed cell death of inflammatory cells by apoptosis" EXACT []
synonym: "programmed cell death, inflammatory cells" EXACT []
is_a: GO:0006915 ! apoptosis

[Term]
id: GO:0006926
name: virus-infected cell apoptosis
namespace: biological_process
def: "The process of apoptosis in cells infected with a virus." [GOC:jl]
synonym: "apoptosis of virus-infected cells" EXACT []
synonym: "killing virus-infected cells" EXACT []
synonym: "programmed cell death of virus-infected cells by apoptosis" EXACT []
synonym: "programmed cell death, virus-infected cells" EXACT []
synonym: "virus-infected cell programmed cell death by apoptosis" EXACT []
is_a: GO:0006915 ! apoptosis

[Term]
id: GO:0006927
name: transformed cell apoptosis
namespace: biological_process
def: "The process of apoptosis in transformed cells, cells that have undergone changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm." [GOC:jl, MeSH:C04.697.152]
synonym: "apoptosis of transformed cells" EXACT []
synonym: "killing transformed cells" EXACT []
synonym: "programmed cell death of transformed cells by apoptosis" EXACT []
synonym: "programmed cell death, transformed cells" EXACT []
synonym: "transformed cell programmed cell death by apoptosis" EXACT []
is_a: GO:0006915 ! apoptosis

[Term]
id: GO:0006928
name: cellular component movement
namespace: biological_process
def: "The directed, self-propelled movement of a cellular component without the involvement of an external agent such as a transporter or a pore." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg]
comment: Note that in GO cellular components include whole cells (cell is_a cellular component).
subset: goslim_goa
subset: goslim_pir
subset: gosubset_prok
synonym: "cell movement" RELATED []
synonym: "cellular component motion" EXACT [GOC:dph, GOC:jl]
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0006929
name: substrate-bound cell migration
namespace: biological_process
def: "The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate." [ISBN:0815316194, PMID:11944043, PMID:14657486]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0006930
name: substrate-bound cell migration, cell extension
namespace: biological_process
def: "The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell." [ISBN:0815316194, PMID:11944043, PMID:14657486]
is_a: GO:0030031 ! cell projection assembly
relationship: part_of GO:0006929 ! substrate-bound cell migration

[Term]
id: GO:0006931
name: substrate-bound cell migration, cell attachment to substrate
namespace: biological_process
def: "The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions." [ISBN:0815316194, PMID:11944043, PMID:14657486]
is_a: GO:0031589 ! cell-substrate adhesion
relationship: part_of GO:0006929 ! substrate-bound cell migration

[Term]
id: GO:0006932
name: substrate-bound cell migration, cell contraction
namespace: biological_process
def: "The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves." [ISBN:0815316194, PMID:11944043, PMID:14657486]
is_a: GO:0070252 ! actin-mediated cell contraction
relationship: part_of GO:0001667 ! ameboidal cell migration
relationship: part_of GO:0006929 ! substrate-bound cell migration

[Term]
id: GO:0006933
name: negative regulation of cell adhesion involved in substrate-bound cell migration
namespace: biological_process
def: "The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction." [GOC:dph, GOC:tb, ISBN:0815316194, PMID:11944043, PMID:14657486]
synonym: "substrate-bound cell migration, cell release from substrate" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007162 ! negative regulation of cell adhesion
relationship: part_of GO:0006929 ! substrate-bound cell migration

[Term]
id: GO:0006934
name: substrate-bound cell migration, adhesion receptor recycling
namespace: biological_process
def: "The directed movement of accumulated adhesion components such as integrins from the rear of a migrating cell toward the cell front, where they are available to form new protrusions and adhesions." [PMID:11944043]
is_a: GO:0001881 ! receptor recycling
relationship: part_of GO:0006933 ! negative regulation of cell adhesion involved in substrate-bound cell migration

[Term]
id: GO:0006935
name: chemotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "taxis in response to chemical stimulus" EXACT []
xref: Wikipedia:Chemotaxis
is_a: GO:0042221 ! response to chemical stimulus
is_a: GO:0042330 ! taxis

[Term]
id: GO:0006936
name: muscle contraction
namespace: biological_process
def: "A process whereby force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
xref: Wikipedia:Muscle_contraction
is_a: GO:0003012 ! muscle system process

[Term]
id: GO:0006937
name: regulation of muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators]
is_a: GO:0090257 ! regulation of muscle system process
relationship: regulates GO:0006936 ! muscle contraction

[Term]
id: GO:0006939
name: smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "visceral muscle contraction" EXACT []
is_a: GO:0006936 ! muscle contraction

[Term]
id: GO:0006940
name: regulation of smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]
is_a: GO:0006937 ! regulation of muscle contraction
relationship: regulates GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0006941
name: striated muscle contraction
namespace: biological_process
def: "A process whereby force is generated within striated muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "sarcomeric muscle contraction" EXACT []
is_a: GO:0006936 ! muscle contraction

[Term]
id: GO:0006942
name: regulation of striated muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators]
is_a: GO:0006937 ! regulation of muscle contraction
relationship: regulates GO:0006941 ! striated muscle contraction

[Term]
id: GO:0006943
name: chemi-mechanical coupling
namespace: biological_process
def: "OBSOLETE. The conversion of chemical energy into mechanical work (as in the contraction of a muscle)." [GOC:jic, http://www.m-w.com]
comment: This term was made obsolete because its meaning is vague, and it does not fit with other terms in GO.
synonym: "mechanochemical coupling" EXACT []
is_obsolete: true
consider: GO:0009612
consider: GO:0050954

[Term]
id: GO:0006944
name: cellular membrane fusion
namespace: biological_process
def: "The cellular process that joins two lipid bilayers to form a single membrane." [GOC:mah]
subset: goslim_goa
xref: Wikipedia:Lipid_bilayer_fusion
is_a: GO:0016044 ! cellular membrane organization
is_a: GO:0061025 ! membrane fusion

[Term]
id: GO:0006945
name: nuclear fusion during karyogamy
namespace: biological_process
def: "OBSOLETE. The fusion of two haploid nuclei to form a single diploid nucleus, as seen in the yeast mating process." [PMID:9442101]
comment: This term was made obsolete because it is redundant outside the context of Saccharomyces biology.
is_obsolete: true
consider: GO:0000741

[Term]
id: GO:0006948
name: induction by virus of host cell-cell fusion
namespace: biological_process
def: "The process of syncytia-forming cell-cell fusion, caused by a virus." [ISBN:0781718325]
synonym: "induction by virus of cell-cell fusion in host" EXACT []
synonym: "viral-induced cell-cell fusion" EXACT []
synonym: "viral-induced host cell-cell fusion" EXACT []
synonym: "viral-induced membrane fusion" NARROW []
is_a: GO:0019048 ! virus-host interaction

[Term]
id: GO:0006949
name: syncytium formation
namespace: biological_process
def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
is_a: GO:0009987 ! cellular process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0006950
name: response to stress
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "response to abiotic stress" RELATED []
synonym: "response to biotic stress" RELATED []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0006952
name: defense response
namespace: biological_process
alt_id: GO:0002217
alt_id: GO:0042829
def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators]
subset: gosubset_prok
synonym: "antimicrobial peptide activity" RELATED []
synonym: "defence response" EXACT []
synonym: "defense/immunity protein activity" RELATED []
synonym: "physiological defense response" EXACT []
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0006953
name: acute-phase response
namespace: biological_process
def: "Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0002526 ! acute inflammatory response

[Term]
id: GO:0006954
name: inflammatory response
namespace: biological_process
def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, GOC:mtg_15nov05, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was improved by GO_REF:0000022. It was moved.
xref: Wikipedia:Inflammation
is_a: GO:0006952 ! defense response
is_a: GO:0009611 ! response to wounding

[Term]
id: GO:0006955
name: immune response
namespace: biological_process
def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]
comment: This term was improved by GO_REF:0000022. It was redefined and moved.
is_a: GO:0002376 ! immune system process
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0006956
name: complement activation
namespace: biological_process
def: "Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was improved by GO_REF:0000022. It was moved.
synonym: "complement activity" RELATED []
synonym: "complement response" EXACT []
xref: Reactome:166663 "Initial triggering of complement"
xref: Reactome:448711 "Initial triggering of complement"
xref: Reactome:469833 "Initial triggering of complement"
xref: Reactome:487526 "Initial triggering of complement"
xref: Reactome:507712 "Initial triggering of complement"
is_a: GO:0002252 ! immune effector process
is_a: GO:0002253 ! activation of immune response
is_a: GO:0002541 ! activation of plasma proteins involved in acute inflammatory response
is_a: GO:0006959 ! humoral immune response

[Term]
id: GO:0006957
name: complement activation, alternative pathway
namespace: biological_process
def: "Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
xref: Reactome:173736 "Alternative complement activation"
xref: Reactome:448938 "Alternative complement activation"
xref: Reactome:470056 "Alternative complement activation"
xref: Reactome:487781 "Alternative complement activation"
xref: Reactome:507711 "Alternative complement activation"
is_a: GO:0006956 ! complement activation
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0006958
name: complement activation, classical pathway
namespace: biological_process
def: "Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
xref: Reactome:173623 "Classical antibody-mediated complement activation"
is_a: GO:0006956 ! complement activation
relationship: part_of GO:0002455 ! humoral immune response mediated by circulating immunoglobulin

[Term]
id: GO:0006959
name: humoral immune response
namespace: biological_process
def: "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: Wikipedia:Humoral_immunity
is_a: GO:0006955 ! immune response

[Term]
id: GO:0006962
name: male-specific antibacterial humoral response
namespace: biological_process
def: "An immune response against bacteria, specific to males and mediated through a body fluid." [GOC:go_curators]
is_a: GO:0019731 ! antibacterial humoral response
is_a: GO:0050831 ! male-specific defense response to bacterium

[Term]
id: GO:0006963
name: positive regulation of antibacterial peptide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475]
synonym: "activation of antibacterial peptide biosynthetic process" NARROW []
synonym: "antibacterial peptide induction" EXACT []
synonym: "antibacterial polypeptide induction" EXACT []
synonym: "stimulation of antibacterial peptide biosynthetic process" NARROW []
synonym: "up regulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "up-regulation of antibacterial peptide biosynthetic process" EXACT []
synonym: "upregulation of antibacterial peptide biosynthetic process" EXACT []
is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process
is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process
relationship: positively_regulates GO:0002780 ! antibacterial peptide biosynthetic process

[Term]
id: GO:0006964
name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475]
synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW []
synonym: "anti-Gram-negative bacterial peptide induction" EXACT []
synonym: "anti-Gram-negative bacterial polypeptide induction" EXACT []
synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW []
synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT []
is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process
relationship: positively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria

[Term]
id: GO:0006965
name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:mah, PMID:10973475]
synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW []
synonym: "anti-Gram-positive bacterial peptide induction" EXACT []
synonym: "anti-Gram-positive bacterial polypeptide induction" EXACT []
synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW []
synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT []
is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process
relationship: positively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria

[Term]
id: GO:0006967
name: positive regulation of antifungal peptide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah]
synonym: "activation of antifungal peptide biosynthetic process" NARROW []
synonym: "antifungal peptide induction" EXACT []
synonym: "antifungal polypeptide induction" EXACT []
synonym: "stimulation of antifungal peptide biosynthetic process" NARROW []
synonym: "up regulation of antifungal peptide biosynthetic process" EXACT []
synonym: "up-regulation of antifungal peptide biosynthetic process" EXACT []
synonym: "upregulation of antifungal peptide biosynthetic process" EXACT []
is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process
is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process
relationship: positively_regulates GO:0002783 ! antifungal peptide biosynthetic process

[Term]
id: GO:0006968
name: cellular defense response
namespace: biological_process
alt_id: GO:0016066
alt_id: GO:0016067
def: "A defense response that is mediated by cells." [GOC:ebc]
comment: Note that this term refers to any type of defense response made by any cell, whether only a single-celled organism or part of a multicellular organism; also includes responses that occur in the context of multiorganism processes.
synonym: "cellular defence response" EXACT []
is_a: GO:0006952 ! defense response

[Term]
id: GO:0006969
name: melanotic tumor response
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:add]
comment: This term was made obsolete because it was undefined and represented an abnormal process.
synonym: "melanotic mass response" EXACT []
is_obsolete: true

[Term]
id: GO:0006970
name: response to osmotic stress
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl]
subset: gosubset_prok
synonym: "osmotic response" EXACT []
synonym: "osmotic stress response" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0006971
name: hypotonic response
namespace: biological_process
def: "A change in state or activity of a cell or an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:jl, http://cancerweb.ncl.ac.uk/]
synonym: "hypo-osmotic response" EXACT []
is_a: GO:0006970 ! response to osmotic stress

[Term]
id: GO:0006972
name: hyperosmotic response
namespace: biological_process
def: "A change in state or activity of a cell or an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:jl, http://cancerweb.ncl.ac.uk/]
synonym: "HOG response" EXACT []
synonym: "hypertonic response" EXACT []
is_a: GO:0006970 ! response to osmotic stress

[Term]
id: GO:0006973
name: intracellular accumulation of glycerol
namespace: biological_process
def: "The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment." [GOC:jl, PMID:11752666]
is_a: GO:0019725 ! cellular homeostasis
relationship: part_of GO:0071474 ! cellular hyperosmotic response

[Term]
id: GO:0006974
name: response to DNA damage stimulus
namespace: biological_process
alt_id: GO:0034984
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators]
subset: gosubset_prok
synonym: "cellular DNA damage response" EXACT []
synonym: "cellular response to DNA damage stimulus" EXACT []
synonym: "DNA damage response" EXACT []
synonym: "response to genotoxic stress" EXACT []
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0006975
name: DNA damage induced protein phosphorylation
namespace: biological_process
def: "The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006468 ! protein amino acid phosphorylation
is_a: GO:0006974 ! response to DNA damage stimulus

[Term]
id: GO:0006977
name: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
namespace: biological_process
def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle." [GOC:go_curators]
synonym: "positive regulation of cell cycle arrest by p53-mediated DNA damage response" EXACT [GOC:dph, GOC:mah]
is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator
is_a: GO:0071158 ! positive regulation of cell cycle arrest
relationship: part_of GO:0031571 ! G1/S DNA damage checkpoint

[Term]
id: GO:0006978
name: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
namespace: biological_process
def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage." [PMID:10967424]
is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator
is_a: GO:0042772 ! DNA damage response, signal transduction resulting in transcription

[Term]
id: GO:0006979
name: response to oxidative stress
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731]
subset: gosubset_prok
is_a: GO:0006950 ! response to stress
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0006981
name: activation of SoxR protein
namespace: biological_process
def: "The conversion of the SoxR transcription factor to its active (oxidized) form." [GOC:jl, PMID:8816757]
subset: gosubset_prok
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:0071461 ! cellular response to redox state

[Term]
id: GO:0006982
name: response to lipid hydroperoxide
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids." [GOC:jl, PMID:10944149]
subset: gosubset_prok
synonym: "response to LHPO" EXACT []
is_a: GO:0033194 ! response to hydroperoxide

[Term]
id: GO:0006983
name: ER overload response
namespace: biological_process
def: "The series of molecular signals generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB." [PMID:10390516]
synonym: "endoplasmic reticulum overload response" EXACT []
synonym: "EOR" EXACT []
synonym: "ER-overload response" EXACT []
is_a: GO:0006984 ! ER-nuclear signaling pathway
is_a: GO:0034976 ! response to endoplasmic reticulum stress
is_a: GO:0071216 ! cellular response to biotic stimulus

[Term]
id: GO:0006984
name: ER-nuclear signaling pathway
namespace: biological_process
def: "Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation." [GOC:mah]
synonym: "endoplasmic reticulum to nucleus signaling pathway" EXACT []
synonym: "endoplasmic reticulum-nuclear signaling pathway" EXACT []
synonym: "ER to nucleus signaling pathway" EXACT []
synonym: "ER to nucleus signalling pathway" EXACT []
synonym: "ER-nuclear signalling pathway" EXACT []
is_a: GO:0023034 ! intracellular signaling pathway

[Term]
id: GO:0006985
name: positive regulation of NF-kappaB transcription factor activity by ER overload response
namespace: biological_process
def: "The conversion of inactive NF-kappaB to the active form, thereby allowing it to activate transcription of target genes, as a result of signaling from the endoplasmic reticulum." [GOC:dph, GOC:mah, GOC:tb, PMID:10390516]
synonym: "EOR-mediated activation of NF-kappaB " EXACT [GOC:dph, GOC:tb]
synonym: "EOR-mediated NF-kappaB activation" EXACT []
synonym: "positive regulation of NF-kappaB transcription factor activity by EOR" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051092 ! positive regulation of NF-kappaB transcription factor activity
relationship: part_of GO:0006983 ! ER overload response

[Term]
id: GO:0006986
name: response to unfolded protein
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl]
comment: Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to one specific response to the presence of unfolded proteins in the ER.
subset: gosubset_prok
synonym: "heat shock protein activity" RELATED []
is_a: GO:0006950 ! response to stress
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0051789 ! response to protein stimulus

[Term]
id: GO:0006987
name: activation of signaling protein activity involved in unfolded protein response
namespace: biological_process
def: "The conversion of a specific protein, possessing protein kinase and endoribonuclease activities, to an active form as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, PMID:12042763]
synonym: "unfolded protein response, activation of signaling protein activity" EXACT [GOC:dph, GOC:tb]
synonym: "unfolded protein response, activation of signaling protein kinase/endonuclease" EXACT []
synonym: "unfolded protein response, activation of signalling protein kinase/endonuclease" EXACT []
is_a: GO:0032075 ! positive regulation of nuclease activity
is_a: GO:0045860 ! positive regulation of protein kinase activity
relationship: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response

[Term]
id: GO:0006988
name: unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a function rather than a process.
is_obsolete: true
consider: GO:0004521
consider: GO:0030969

[Term]
id: GO:0006989
name: unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a function rather than a process.
is_obsolete: true
consider: GO:0008452
consider: GO:0030969

[Term]
id: GO:0006990
name: positive regulation of gene-specific transcription involved in unfolded protein response
namespace: biological_process
def: "The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, PMID:12042763]
synonym: "positive regulation of transcription of target genes involved in unfolded protein response" EXACT [GOC:dph, GOC:tb]
synonym: "unfolded protein response, activation of target gene transcription" NARROW []
synonym: "unfolded protein response, positive regulation of target gene transcription" EXACT [GOC:tb]
synonym: "unfolded protein response, stimulation of target gene transcription" NARROW []
synonym: "unfolded protein response, target gene transcriptional activation" BROAD []
synonym: "unfolded protein response, up regulation of target gene transcription" EXACT []
synonym: "unfolded protein response, up-regulation of target gene transcription" EXACT []
synonym: "unfolded protein response, upregulation of target gene transcription" EXACT []
is_a: GO:0043193 ! positive regulation of gene-specific transcription
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response

[Term]
id: GO:0006991
name: response to sterol depletion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "sterol depletion response" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0006992
name: sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway
namespace: biological_process
def: "The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to depleted sterol levels." [GOC:bf, PMID:12923525]
synonym: "sterol depletion response, SREBP cleavage" EXACT []
is_a: GO:0035103 ! sterol regulatory element binding protein cleavage
relationship: part_of GO:0030967 ! ER-nuclear sterol response pathway

[Term]
id: GO:0006993
name: sterol regulatory element binding protein nuclear translocation involved in sterol depletion response
namespace: biological_process
def: "The transfer of a sterol regulatory element binding protein (SREBP) into the nucleus across the nuclear membrane, in response to sterol depletion. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525]
synonym: "sterol depletion response, SREBP nuclear translocation" EXACT []
synonym: "sterol depletion response, sterol regulatory element binding protein nuclear translocation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0035105 ! sterol regulatory element binding protein nuclear translocation
relationship: part_of GO:0030967 ! ER-nuclear sterol response pathway

[Term]
id: GO:0006994
name: positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway
namespace: biological_process
def: "The process by which a sterol regulatory element binding protein (SREBP) mediates an increase in rate or extent of transcription of nuclear target genes in response to sterol depletion. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525]
synonym: "positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response" EXACT [GOC:dph, GOC:tb]
synonym: "sterol depletion response, SREBP target gene transcriptional activation" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0035104 ! positive regulation of transcription via sterol regulatory element binding
relationship: part_of GO:0030967 ! ER-nuclear sterol response pathway

[Term]
id: GO:0006995
name: cellular response to nitrogen starvation
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen." [GOC:jl]
subset: gosubset_prok
is_a: GO:0009267 ! cellular response to starvation
is_a: GO:0043562 ! cellular response to nitrogen levels

[Term]
id: GO:0006996
name: organelle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
synonym: "organelle organisation" EXACT [GOC:curators]
synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0009987 ! cellular process
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0006997
name: nucleus organization
namespace: biological_process
alt_id: GO:0048287
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
synonym: "nuclear morphology" RELATED []
synonym: "nuclear organisation" EXACT [GOC:curators]
synonym: "nuclear organization" EXACT [GOC:curators]
synonym: "nuclear organization and biogenesis" RELATED [GOC:mah]
synonym: "nucleus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0006998
name: nuclear envelope organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
synonym: "nuclear envelope organisation" EXACT [GOC:mah]
synonym: "nuclear envelope organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006997 ! nucleus organization
is_a: GO:0016044 ! cellular membrane organization

[Term]
id: GO:0006999
name: nuclear pore organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore." [GOC:dph, GOC:jic, GOC:jl, GOC:mah]
synonym: "nuclear pore complex organization and biogenesis" RELATED [GOC:mah]
synonym: "nuclear pore organisation" EXACT [GOC:curators]
synonym: "nuclear pore organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006997 ! nucleus organization
is_a: GO:0034621 ! cellular macromolecular complex subunit organization

[Term]
id: GO:0007000
name: nucleolus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly the nucleolus." [GOC:dph, GOC:jic, GOC:jl, GOC:mah]
synonym: "nucleolus organisation" EXACT [GOC:curators]
synonym: "nucleolus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006997 ! nucleus organization

[Term]
id: GO:0007002
name: centromere binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
is_obsolete: true
replaced_by: GO:0019237

[Term]
id: GO:0007003
name: telomere binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
is_obsolete: true
replaced_by: GO:0042162

[Term]
id: GO:0007004
name: telomere maintenance via telomerase
namespace: biological_process
def: "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh]
synonym: "telomerase-dependent telomere maintenance" EXACT []
xref: Reactome:163090 "Elongation Of The Telomeric Chromosome End"
xref: Reactome:163096 "Recruitment of Telomerase RNP to the Telomeric Chromosome End"
xref: Reactome:163099 "Alignment Of The RNA Template On The Telomeric Chromosome End"
xref: Reactome:163120 "Disassociation of Telomerase RNP and the Chromosome End"
xref: Reactome:164616 "Biogenesis And Assembly Of The Telomerase RNP"
xref: Reactome:164617 "Elongation of Extended Telomeric Chromosome End"
xref: Reactome:164620 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End"
xref: Reactome:171319 "Telomere Extension By Telomerase"
xref: Reactome:430767 "Alignment Of The RNA Template On The Telomeric Chromosome End"
xref: Reactome:436651 "Disassociation of Telomerase RNP and the Chromosome End"
xref: Reactome:437532 "Elongation of Extended Telomeric Chromosome End"
xref: Reactome:437535 "Elongation Of The Telomeric Chromosome End"
xref: Reactome:446140 "Recruitment of Telomerase RNP to the Telomeric Chromosome End"
xref: Reactome:447807 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End"
xref: Reactome:448786 "Telomere Extension By Telomerase"
xref: Reactome:452996 "Alignment Of The RNA Template On The Telomeric Chromosome End"
xref: Reactome:458958 "Disassociation of Telomerase RNP and the Chromosome End"
xref: Reactome:459642 "Elongation of Extended Telomeric Chromosome End"
xref: Reactome:459645 "Elongation Of The Telomeric Chromosome End"
xref: Reactome:467464 "Recruitment of Telomerase RNP to the Telomeric Chromosome End"
xref: Reactome:469006 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End"
xref: Reactome:469901 "Telomere Extension By Telomerase"
xref: Reactome:473514 "Alignment Of The RNA Template On The Telomeric Chromosome End"
xref: Reactome:478271 "Disassociation of Telomerase RNP and the Chromosome End"
xref: Reactome:478789 "Elongation of Extended Telomeric Chromosome End"
xref: Reactome:478792 "Elongation Of The Telomeric Chromosome End"
xref: Reactome:485451 "Recruitment of Telomerase RNP to the Telomeric Chromosome End"
xref: Reactome:486825 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End"
xref: Reactome:487608 "Telomere Extension By Telomerase"
xref: Reactome:491958 "Alignment Of The RNA Template On The Telomeric Chromosome End"
xref: Reactome:497989 "Disassociation of Telomerase RNP and the Chromosome End"
xref: Reactome:498556 "Elongation of Extended Telomeric Chromosome End"
xref: Reactome:498559 "Elongation Of The Telomeric Chromosome End"
xref: Reactome:505237 "Recruitment of Telomerase RNP to the Telomeric Chromosome End"
xref: Reactome:506653 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End"
xref: Reactome:507563 "Telomere Extension By Telomerase"
xref: Reactome:527730 "Alignment Of The RNA Template On The Telomeric Chromosome End"
xref: Reactome:529039 "Disassociation of Telomerase RNP and the Chromosome End"
xref: Reactome:529167 "Elongation of Extended Telomeric Chromosome End"
xref: Reactome:529168 "Elongation Of The Telomeric Chromosome End"
xref: Reactome:530507 "Recruitment of Telomerase RNP to the Telomeric Chromosome End"
xref: Reactome:530877 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End"
xref: Reactome:531229 "Telomere Extension By Telomerase"
xref: Reactome:532661 "Alignment Of The RNA Template On The Telomeric Chromosome End"
xref: Reactome:534253 "Disassociation of Telomerase RNP and the Chromosome End"
xref: Reactome:534409 "Elongation of Extended Telomeric Chromosome End"
xref: Reactome:534419 "Elongation Of The Telomeric Chromosome End"
xref: Reactome:535913 "Recruitment of Telomerase RNP to the Telomeric Chromosome End"
xref: Reactome:536254 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End"
xref: Reactome:536598 "Telomere Extension By Telomerase"
xref: Reactome:538135 "Alignment Of The RNA Template On The Telomeric Chromosome End"
xref: Reactome:539813 "Disassociation of Telomerase RNP and the Chromosome End"
xref: Reactome:539957 "Elongation of Extended Telomeric Chromosome End"
xref: Reactome:539967 "Elongation Of The Telomeric Chromosome End"
xref: Reactome:541511 "Recruitment of Telomerase RNP to the Telomeric Chromosome End"
xref: Reactome:541930 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End"
xref: Reactome:542324 "Telomere Extension By Telomerase"
xref: Reactome:543757 "Alignment Of The RNA Template On The Telomeric Chromosome End"
xref: Reactome:545485 "Disassociation of Telomerase RNP and the Chromosome End"
xref: Reactome:545652 "Elongation of Extended Telomeric Chromosome End"
xref: Reactome:545662 "Elongation Of The Telomeric Chromosome End"
xref: Reactome:546952 "Recruitment of Telomerase RNP to the Telomeric Chromosome End"
xref: Reactome:547348 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End"
xref: Reactome:547664 "Telomere Extension By Telomerase"
xref: Reactome:548948 "Alignment Of The RNA Template On The Telomeric Chromosome End"
xref: Reactome:550239 "Disassociation of Telomerase RNP and the Chromosome End"
xref: Reactome:550363 "Elongation of Extended Telomeric Chromosome End"
xref: Reactome:550373 "Elongation Of The Telomeric Chromosome End"
xref: Reactome:551611 "Recruitment of Telomerase RNP to the Telomeric Chromosome End"
xref: Reactome:551919 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End"
xref: Reactome:552249 "Telomere Extension By Telomerase"
xref: Reactome:553810 "Alignment Of The RNA Template On The Telomeric Chromosome End"
xref: Reactome:555444 "Disassociation of Telomerase RNP and the Chromosome End"
xref: Reactome:555569 "Elongation of Extended Telomeric Chromosome End"
xref: Reactome:555570 "Elongation Of The Telomeric Chromosome End"
xref: Reactome:557062 "Recruitment of Telomerase RNP to the Telomeric Chromosome End"
xref: Reactome:557464 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End"
xref: Reactome:557868 "Telomere Extension By Telomerase"
xref: Reactome:560576 "Alignment Of The RNA Template On The Telomeric Chromosome End"
xref: Reactome:564408 "Disassociation of Telomerase RNP and the Chromosome End"
xref: Reactome:564670 "Elongation of Extended Telomeric Chromosome End"
xref: Reactome:564673 "Elongation Of The Telomeric Chromosome End"
xref: Reactome:567124 "Recruitment of Telomerase RNP to the Telomeric Chromosome End"
xref: Reactome:567927 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End"
xref: Reactome:568466 "Telomere Extension By Telomerase"
xref: Reactome:571817 "Alignment Of The RNA Template On The Telomeric Chromosome End"
xref: Reactome:576715 "Disassociation of Telomerase RNP and the Chromosome End"
xref: Reactome:577072 "Elongation of Extended Telomeric Chromosome End"
xref: Reactome:577075 "Elongation Of The Telomeric Chromosome End"
xref: Reactome:580138 "Recruitment of Telomerase RNP to the Telomeric Chromosome End"
xref: Reactome:581055 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End"
xref: Reactome:581677 "Telomere Extension By Telomerase"
xref: Reactome:587618 "Alignment Of The RNA Template On The Telomeric Chromosome End"
xref: Reactome:589567 "Disassociation of Telomerase RNP and the Chromosome End"
xref: Reactome:589749 "Elongation of Extended Telomeric Chromosome End"
xref: Reactome:589759 "Elongation Of The Telomeric Chromosome End"
xref: Reactome:591678 "Recruitment of Telomerase RNP to the Telomeric Chromosome End"
xref: Reactome:592186 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End"
xref: Reactome:592586 "Telomere Extension By Telomerase"
is_a: GO:0006278 ! RNA-dependent DNA replication
is_a: GO:0010833 ! telomere maintenance via telomere lengthening

[Term]
id: GO:0007005
name: mitochondrion organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946]
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
synonym: "mitochondria organization" EXACT [GOC:mah]
synonym: "mitochondrion organisation" EXACT [GOC:mah]
synonym: "mitochondrion organization and biogenesis" RELATED [GOC:curators]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007006
name: mitochondrial membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "mitochondrial membrane organisation" EXACT [GOC:curators]
synonym: "mitochondrial membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0016044 ! cellular membrane organization

[Term]
id: GO:0007007
name: inner mitochondrial membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
synonym: "inner mitochondrial membrane organisation" EXACT [GOC:curators]
synonym: "inner mitochondrial membrane organization and biogenesis" RELATED [GOC:mah]
synonym: "mitochondrial inner membrane organization" EXACT [GOC:curators]
is_a: GO:0007006 ! mitochondrial membrane organization

[Term]
id: GO:0007008
name: outer mitochondrial membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
comment: See also the cellular component term 'mitochondrial outer membrane ; GO:0005741'.
synonym: "outer mitochondrial membrane organisation" EXACT [GOC:curators]
synonym: "outer mitochondrial membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007006 ! mitochondrial membrane organization

[Term]
id: GO:0007009
name: plasma membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
subset: gosubset_prok
synonym: "plasma membrane organisation" EXACT [GOC:curators]
synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016044 ! cellular membrane organization

[Term]
id: GO:0007010
name: cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah]
synonym: "cytoskeletal regulator activity" RELATED []
synonym: "cytoskeleton organisation" EXACT [GOC:curators]
synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007011
name: regulation of cytoskeleton
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators]
comment: This term was made obsolete because cytoskeleton is neither a process nor a trait, so the term made no sense.
is_obsolete: true
consider: GO:0007010

[Term]
id: GO:0007014
name: indirect flight muscle actin ubiquitination
namespace: biological_process
is_a: GO:0016567 ! protein ubiquitination
is_a: GO:0030047 ! actin modification

[Term]
id: GO:0007015
name: actin filament organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah]
synonym: "actin filament organisation" EXACT [GOC:curators]
synonym: "regulation of actin filament localization" NARROW []
is_a: GO:0030036 ! actin cytoskeleton organization

[Term]
id: GO:0007016
name: cytoskeletal anchoring at plasma membrane
namespace: biological_process
def: "Process by which cytoskeletal filaments are directly or indirectly linked to the plasma membrane." [ISBN:0198599323]
synonym: "cytoskeletal anchoring activity" RELATED []
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0032507 ! maintenance of protein location in cell

[Term]
id: GO:0007017
name: microtubule-based process
namespace: biological_process
def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah]
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007018
name: microtubule-based movement
namespace: biological_process
def: "Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [ISBN:0815316194]
xref: Reactome:177479 "Axonal transport of NGF:Trk complexes"
xref: Reactome:432878 "Axonal transport of NGF:Trk complexes"
xref: Reactome:455468 "Axonal transport of NGF:Trk complexes"
xref: Reactome:475352 "Axonal transport of NGF:Trk complexes"
xref: Reactome:494338 "Axonal transport of NGF:Trk complexes"
is_a: GO:0007017 ! microtubule-based process

[Term]
id: GO:0007019
name: microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194]
synonym: "microtubule catastrophe" NARROW [GOC:dph, GOC:tb]
synonym: "microtubule depolymerization during nuclear congression" NARROW []
synonym: "microtubule disassembly" EXACT []
is_a: GO:0031109 ! microtubule polymerization or depolymerization
is_a: GO:0051261 ! protein depolymerization

[Term]
id: GO:0007020
name: microtubule nucleation
namespace: biological_process
def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [ISBN:0815316194]
xref: Wikipedia:Microtubule_nucleation
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0007021
name: tubulin complex assembly
namespace: biological_process
def: "The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah]
synonym: "tubulin assembly" EXACT []
synonym: "tubulin folding" RELATED []
synonym: "tubulin-specific chaperone activity" RELATED []
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0007023
name: post-chaperonin tubulin folding pathway
namespace: biological_process
def: "Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors." [PMID:10542094]
xref: Reactome:389977 "Post-chaperonin tubulin folding pathway"
xref: Reactome:391548 "Post-chaperonin tubulin folding pathway"
xref: Reactome:448797 "Post-chaperonin tubulin folding pathway"
xref: Reactome:469913 "Post-chaperonin tubulin folding pathway"
xref: Reactome:487619 "Post-chaperonin tubulin folding pathway"
xref: Reactome:507574 "Post-chaperonin tubulin folding pathway"
xref: Reactome:517547 "Post-chaperonin tubulin folding pathway"
xref: Reactome:526414 "Post-chaperonin tubulin folding pathway"
xref: Reactome:531237 "Post-chaperonin tubulin folding pathway"
xref: Reactome:536608 "Post-chaperonin tubulin folding pathway"
xref: Reactome:542332 "Post-chaperonin tubulin folding pathway"
xref: Reactome:547672 "Post-chaperonin tubulin folding pathway"
xref: Reactome:552257 "Post-chaperonin tubulin folding pathway"
xref: Reactome:557876 "Post-chaperonin tubulin folding pathway"
xref: Reactome:568474 "Post-chaperonin tubulin folding pathway"
xref: Reactome:581685 "Post-chaperonin tubulin folding pathway"
xref: Reactome:592592 "Post-chaperonin tubulin folding pathway"
xref: Reactome:595403 "Post-chaperonin tubulin folding pathway"
is_a: GO:0006457 ! protein folding

[Term]
id: GO:0007026
name: negative regulation of microtubule depolymerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194]
synonym: "down regulation of microtubule depolymerization" EXACT []
synonym: "down-regulation of microtubule depolymerization" EXACT []
synonym: "downregulation of microtubule depolymerization" EXACT []
synonym: "inhibition of microtubule depolymerization" NARROW []
synonym: "microtubule rescue" NARROW [GOC:dph, GOC:tb]
synonym: "microtubule stabilization" EXACT []
synonym: "negative regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb]
synonym: "negative regulation of microtubule disassembly" EXACT []
is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization
is_a: GO:0031114 ! regulation of microtubule depolymerization
is_a: GO:0043242 ! negative regulation of protein complex disassembly
relationship: negatively_regulates GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0007027
name: negative regulation of axonemal microtubule depolymerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme." [GOC:dph, GOC:mah]
synonym: "axonemal microtubule stabilization" EXACT []
synonym: "negative regulation of microtubule depolymerization in axoneme" RELATED [GOC:dph]
is_a: GO:0007026 ! negative regulation of microtubule depolymerization
relationship: negatively_regulates GO:0060404 ! axonemal microtubule depolymerization

[Term]
id: GO:0007028
name: cytoplasm organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:curators, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
synonym: "cytoplasm organisation" EXACT [GOC:curators]
synonym: "cytoplasm organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009987 ! cellular process
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0007029
name: endoplasmic reticulum organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "endoplasmic reticulum morphology" RELATED []
synonym: "endoplasmic reticulum organisation" EXACT [GOC:curators]
synonym: "endoplasmic reticulum organization and biogenesis" RELATED [GOC:mah]
synonym: "ER organisation" EXACT [GOC:curators]
synonym: "ER organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007030
name: Golgi organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "Golgi organisation" EXACT [GOC:curators]
synonym: "Golgi organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007031
name: peroxisome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah]
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
synonym: "peroxisome organisation" EXACT [GOC:curators]
synonym: "peroxisome organization and biogenesis" RELATED [GOC:mah]
synonym: "peroxisome-assembly ATPase activity" RELATED []
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007032
name: endosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "endosome organisation" EXACT [GOC:curators]
synonym: "endosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007033
name: vacuole organization
namespace: biological_process
alt_id: GO:0044086
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah]
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
synonym: "vacuolar assembly" NARROW [GOC:mah]
synonym: "vacuole biogenesis" RELATED [GOC:mah]
synonym: "vacuole organisation" EXACT [GOC:curators]
synonym: "vacuole organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0007034
name: vacuolar transport
namespace: biological_process
def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai]
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0007035
name: vacuolar acidification
namespace: biological_process
def: "Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jic]
is_a: GO:0051452 ! intracellular pH reduction

[Term]
id: GO:0007036
name: vacuolar calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of calcium ions in the vacuole or between a vacuole and its surroundings." [GOC:ai, GOC:mah]
is_a: GO:0006874 ! cellular calcium ion homeostasis

[Term]
id: GO:0007037
name: vacuolar phosphate transport
namespace: biological_process
def: "The directed movement of phosphates into, out of or within a vacuole." [GOC:ai]
is_a: GO:0006817 ! phosphate transport
is_a: GO:0007034 ! vacuolar transport

[Term]
id: GO:0007038
name: endocytosed protein transport to vacuole
namespace: biological_process
def: "The directed movement of proteins imported into a cell by endocytosis to the vacuole." [GOC:ai]
comment: See also the biological process term 'endocytosis ; GO:0006897'.
synonym: "delivery of endocytosed proteins to the vacuole" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0007034 ! vacuolar transport

[Term]
id: GO:0007039
name: vacuolar protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah]
synonym: "vacuolar protein breakdown" EXACT []
synonym: "vacuolar protein catabolism" EXACT []
synonym: "vacuolar protein degradation" EXACT []
is_a: GO:0044257 ! cellular protein catabolic process

[Term]
id: GO:0007040
name: lysosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah]
synonym: "lysosome organisation" EXACT [GOC:curators]
synonym: "lysosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007033 ! vacuole organization

[Term]
id: GO:0007041
name: lysosomal transport
namespace: biological_process
def: "The directed movement of substances into, out of or within a lysosome." [GOC:ai]
is_a: GO:0007034 ! vacuolar transport

[Term]
id: GO:0007042
name: lysosomal lumen acidification
namespace: biological_process
def: "Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jic]
is_a: GO:0051452 ! intracellular pH reduction
relationship: part_of GO:0007040 ! lysosome organization

[Term]
id: GO:0007043
name: cell-cell junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai]
synonym: "intercellular junction assembly" EXACT []
is_a: GO:0034329 ! cell junction assembly
is_a: GO:0045216 ! cell-cell junction organization

[Term]
id: GO:0007044
name: cell-substrate junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah]
is_a: GO:0034329 ! cell junction assembly

[Term]
id: GO:0007045
name: cell-substrate adherens junction assembly
namespace: biological_process
def: "The aggregation, arrangement, and bonding together of a set of components to form a cell-substrate adherens junction." [GOC:mah]
synonym: "hemi-adherens junction assembly" RELATED [GOC:mah]
is_a: GO:0007044 ! cell-substrate junction assembly

[Term]
id: GO:0007047
name: cellular cell wall organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:dph, GOC:jl, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "cell wall organization and biogenesis" RELATED [GOC:mah]
synonym: "cell wall organization at cellular level" EXACT [GOC:mah]
synonym: "cellular cell wall organisation" EXACT [GOC:curators]
is_a: GO:0045229 ! external encapsulating structure organization
is_a: GO:0070882 ! cellular cell wall organization or biogenesis
is_a: GO:0071555 ! cell wall organization

[Term]
id: GO:0007048
name: oncogenesis
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a pathological process.
is_obsolete: true

[Term]
id: GO:0007049
name: cell cycle
namespace: biological_process
def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "cell-division cycle" EXACT []
xref: Wikipedia:Cell_cycle
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007050
name: cell cycle arrest
namespace: biological_process
def: "The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb]
synonym: "arrest of cell cycle progression" EXACT []
synonym: "cessation of cell cycle" EXACT []
synonym: "termination of cell cycle" EXACT []
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0007051
name: spindle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:mah]
synonym: "spindle organisation" EXACT [GOC:curators]
synonym: "spindle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0007052
name: mitotic spindle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah]
synonym: "mitotic spindle organisation" EXACT [GOC:curators]
synonym: "mitotic spindle organization and biogenesis" RELATED [GOC:mah]
synonym: "spindle organization and biogenesis during mitosis" EXACT []
is_a: GO:0007051 ! spindle organization
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007053
name: spindle assembly involved in male meiosis
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah]
is_a: GO:0000212 ! meiotic spindle organization
is_a: GO:0051225 ! spindle assembly
relationship: part_of GO:0007140 ! male meiosis

[Term]
id: GO:0007054
name: spindle assembly involved in male meiosis I
namespace: biological_process
def: "The formation of the spindle during meiosis I of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah]
synonym: "male meiosis I spindle assembly" RELATED []
is_a: GO:0007053 ! spindle assembly involved in male meiosis
relationship: part_of GO:0007141 ! male meiosis I

[Term]
id: GO:0007055
name: spindle assembly involved male meiosis II
namespace: biological_process
def: "The formation of the spindle during meiosis II of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah]
synonym: "male meiosis II spindle assembly" RELATED []
is_a: GO:0007053 ! spindle assembly involved in male meiosis
relationship: part_of GO:0007142 ! male meiosis II

[Term]
id: GO:0007056
name: spindle assembly involved in female meiosis
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah]
synonym: "female meiotic spindle assembly" RELATED []
is_a: GO:0000212 ! meiotic spindle organization
is_a: GO:0051225 ! spindle assembly
relationship: part_of GO:0007143 ! female meiosis

[Term]
id: GO:0007057
name: spindle assembly involved in female meiosis I
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah]
synonym: "female meiosis I spindle assembly" RELATED []
is_a: GO:0007056 ! spindle assembly involved in female meiosis
relationship: part_of GO:0007144 ! female meiosis I

[Term]
id: GO:0007058
name: spindle assembly involved in female meiosis II
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah]
synonym: "female meiosis II spindle assembly" RELATED []
is_a: GO:0007056 ! spindle assembly involved in female meiosis
relationship: part_of GO:0007147 ! female meiosis II

[Term]
id: GO:0007059
name: chromosome segregation
namespace: biological_process
def: "The process by which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets." [GOC:ai]
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "chromosome division" EXACT []
synonym: "chromosome transmission" RELATED []
xref: Wikipedia:Chromosome_segregation
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007060
name: male meiosis chromosome segregation
namespace: biological_process
def: "The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male." [GOC:ai]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0045132 ! meiotic chromosome segregation
relationship: part_of GO:0007140 ! male meiosis

[Term]
id: GO:0007062
name: sister chromatid cohesion
namespace: biological_process
def: "The cell cycle process by which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome." [GOC:mah, ISBN:0815316194]
xref: Reactome:163048 "Phosphorylation of the SA2 Cohesion Complex"
xref: Reactome:445430 "Phosphorylation of the SA2 Cohesion Complex"
xref: Reactome:466775 "Phosphorylation of the SA2 Cohesion Complex"
xref: Reactome:484939 "Phosphorylation of the SA2 Cohesion Complex"
xref: Reactome:504718 "Phosphorylation of the SA2 Cohesion Complex"
xref: Reactome:515924 "Phosphorylation of the SA2 Cohesion Complex"
xref: Reactome:524977 "Phosphorylation of the SA2 Cohesion Complex"
xref: Reactome:530340 "Phosphorylation of the SA2 Cohesion Complex"
xref: Reactome:535718 "Phosphorylation of the SA2 Cohesion Complex"
xref: Reactome:541389 "Phosphorylation of the SA2 Cohesion Complex"
xref: Reactome:546848 "Phosphorylation of the SA2 Cohesion Complex"
xref: Reactome:551516 "Phosphorylation of the SA2 Cohesion Complex"
xref: Reactome:556946 "Phosphorylation of the SA2 Cohesion Complex"
xref: Reactome:585195 "Phosphorylation of the SA2 Cohesion Complex"
xref: Reactome:591552 "Phosphorylation of the SA2 Cohesion Complex"
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051276 ! chromosome organization
relationship: part_of GO:0007059 ! chromosome segregation

[Term]
id: GO:0007063
name: regulation of sister chromatid cohesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0051983 ! regulation of chromosome segregation
relationship: regulates GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0007064
name: mitotic sister chromatid cohesion
namespace: biological_process
def: "The cell cycle process whereby the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866]
is_a: GO:0007062 ! sister chromatid cohesion
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0007065
name: male meiosis sister chromatid cohesion
namespace: biological_process
def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male." [GOC:ai]
is_a: GO:0051177 ! meiotic sister chromatid cohesion
relationship: part_of GO:0007140 ! male meiosis

[Term]
id: GO:0007066
name: female meiosis sister chromatid cohesion
namespace: biological_process
def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female." [GOC:ai]
is_a: GO:0051177 ! meiotic sister chromatid cohesion
relationship: part_of GO:0007143 ! female meiosis

[Term]
id: GO:0007067
name: mitosis
namespace: biological_process
def: "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684]
xref: Wikipedia:Mitosis
is_a: GO:0000280 ! nuclear division
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0000087 ! M phase of mitotic cell cycle

[Term]
id: GO:0007068
name: negative regulation of transcription, mitotic
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription during mitosis." [GOC:go_curators]
synonym: "down regulation of transcription, mitotic" EXACT []
synonym: "down-regulation of transcription, mitotic" EXACT []
synonym: "downregulation of transcription, mitotic" EXACT []
synonym: "inhibition of transcription, mitotic" NARROW []
synonym: "mitotic repression of transcription" EXACT []
synonym: "negative regulation of transcription during mitosis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent
is_a: GO:0045896 ! regulation of transcription, mitotic

[Term]
id: GO:0007069
name: negative regulation of transcription from RNA polymerase I promoter, mitotic
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators]
synonym: "down regulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
synonym: "down-regulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
synonym: "downregulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
synonym: "inhibition of transcription from RNA polymerase I promoter, mitotic" NARROW []
synonym: "mitotic repression of transcription from Pol I promoter" EXACT []
synonym: "negative regulation of transcription from Pol I promoter, mitotic" EXACT []
synonym: "negative regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007068 ! negative regulation of transcription, mitotic
is_a: GO:0016479 ! negative regulation of transcription from RNA polymerase I promoter
is_a: GO:0046017 ! regulation of transcription from RNA polymerase I promoter, mitotic

[Term]
id: GO:0007070
name: negative regulation of transcription from RNA polymerase II promoter, mitotic
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators]
synonym: "down regulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter, mitotic" NARROW []
synonym: "mitotic repression of transcription from Pol II promoter" EXACT []
synonym: "negative regulation of transcription from Pol II promoter, mitotic" EXACT []
synonym: "negative regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0007068 ! negative regulation of transcription, mitotic
is_a: GO:0046021 ! regulation of transcription from RNA polymerase II promoter, mitotic

[Term]
id: GO:0007071
name: negative regulation of transcription from RNA polymerase III promoter, mitotic
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators]
synonym: "down regulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
synonym: "down-regulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
synonym: "downregulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
synonym: "inhibition of transcription from RNA polymerase III promoter, mitotic" NARROW []
synonym: "mitotic repression of transcription from Pol III promoter" EXACT []
synonym: "negative regulation of transcription from Pol III promoter, mitotic" EXACT []
synonym: "negative regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007068 ! negative regulation of transcription, mitotic
is_a: GO:0016480 ! negative regulation of transcription from RNA polymerase III promoter
is_a: GO:0046023 ! regulation of transcription from RNA polymerase III promoter, mitotic

[Term]
id: GO:0007072
name: positive regulation of transcription on exit from mitosis
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:isa_complete, GOC:tb]
synonym: "activation of transcription on exit from mitosis" NARROW [GOC:dph, GOC:tb]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0045941 ! positive regulation of transcription
relationship: part_of GO:0010458 ! exit from mitosis

[Term]
id: GO:0007073
name: positive regulation of transcription on exit from mitosis, from RNA polymerase I promoter
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase I promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]
synonym: "activation of transcription on exit from mitosis, from Pol I promoter" NARROW [GOC:dph, GOC:tb]
synonym: "activation of transcription on exit from mitosis, from RNA polymerase I promoter" NARROW []
is_a: GO:0007072 ! positive regulation of transcription on exit from mitosis

[Term]
id: GO:0007074
name: positive regulation of transcription on exit from mitosis, from RNA polymerase II promoter
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]
synonym: "activation of transcription on exit from mitosis, from Pol II promoter" NARROW []
synonym: "activation of transcription on exit from mitosis, from RNA polymerase II promoter" NARROW []
is_a: GO:0007072 ! positive regulation of transcription on exit from mitosis

[Term]
id: GO:0007075
name: positive regulation of transcription on exit from mitosis, from RNA polymerase III promoter
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase III promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]
synonym: "activation of transcription on exit from mitosis, from Pol III promoter" NARROW []
synonym: "activation of transcription on exit from mitosis, from RNA polymerase III promoter" NARROW [GOC:dph, GOC:tb]
is_a: GO:0007072 ! positive regulation of transcription on exit from mitosis

[Term]
id: GO:0007076
name: mitotic chromosome condensation
namespace: biological_process
def: "The cell cycle process whereby chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0030261 ! chromosome condensation
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0007077
name: mitotic nuclear envelope disassembly
namespace: biological_process
def: "The cell cycle process whereby the controlled breakdown of the nuclear envelope during mitotic cell division occurs." [GOC:bf]
synonym: "mitotic nuclear envelope breakdown" EXACT []
synonym: "mitotic nuclear envelope catabolism" EXACT []
synonym: "mitotic nuclear envelope degradation" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051081 ! nuclear envelope disassembly
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007078
name: lamin depolymerization
namespace: biological_process
def: "The cell cycle process whereby lamin is depolymerized." [GOC:jic]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051261 ! protein depolymerization
relationship: part_of GO:0007077 ! mitotic nuclear envelope disassembly

[Term]
id: GO:0007079
name: mitotic chromosome movement towards spindle pole
namespace: biological_process
alt_id: GO:0007082
def: "The cell cycle process whereby the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis." [GOC:ai]
synonym: "chromosome migration to spindle pole during mitosis" EXACT []
synonym: "chromosome movement towards spindle pole during mitosis" EXACT []
synonym: "mitotic chromosome movement" BROAD []
synonym: "mitotic chromosome movement to spindle pole" EXACT []
synonym: "mitotic sister chromosome movement towards spindle pole" EXACT []
synonym: "sister chromosome movement towards spindle pole during mitosis" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051305 ! chromosome movement towards spindle pole
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0007080
name: mitotic metaphase plate congression
namespace: biological_process
def: "The cell cycle process whereby chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis." [GOC:mah, ISBN:0815316194]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051310 ! metaphase plate congression
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0007081
name: mitotic sister-chromatid adhesion release
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the term name is ambiguous and appears to encompass two processes.
is_obsolete: true
consider: GO:0000070
consider: GO:0007064

[Term]
id: GO:0007083
name: mitotic chromosome decondensation
namespace: biological_process
def: "The cell cycle process whereby chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells." [GOC:ai]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051312 ! chromosome decondensation
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0007084
name: mitotic nuclear envelope reassembly
namespace: biological_process
def: "The cell cycle process whereby the nuclear envelope reforms during mitotic cell division." [GOC:ai]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0031468 ! nuclear envelope reassembly
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007085
name: nuclear membrane vesicle binding to chromatin
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a molecular function.
is_obsolete: true
consider: GO:0003682

[Term]
id: GO:0007086
name: vesicle fusion with nuclear membrane
namespace: biological_process
def: "The cell cycle process whereby the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus occurs." [GOC:jic]
is_a: GO:0006906 ! vesicle fusion
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly

[Term]
id: GO:0007087
name: mitotic nuclear pore complex reassembly
namespace: biological_process
def: "The cell cycle process whereby nuclear pore complexes reform during mitotic cell division." [GOC:ai]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051292 ! nuclear pore complex assembly
relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly

[Term]
id: GO:0007088
name: regulation of mitosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051783 ! regulation of nuclear division
relationship: regulates GO:0007067 ! mitosis

[Term]
id: GO:0007089
name: traversing start control point of mitotic cell cycle
namespace: biological_process
alt_id: GO:0000081
def: "Passage through a cell cycle control point late in G1 phase of the mitotic cell cycle just before entry into S phase; in most organisms studied, including budding yeast and animal cells, passage through start normally commits the cell to progressing through the entire cell cycle." [GOC:mah, ISBN:0815316194]
synonym: "G1 checkpoint" RELATED []
is_a: GO:0007346 ! regulation of mitotic cell cycle
relationship: part_of GO:0000080 ! G1 phase of mitotic cell cycle

[Term]
id: GO:0007090
name: regulation of S phase of mitotic cell cycle
namespace: biological_process
def: "A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle." [GOC:go_curators]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0033261 ! regulation of S phase
relationship: regulates GO:0000084 ! S phase of mitotic cell cycle

[Term]
id: GO:0007091
name: mitotic metaphase/anaphase transition
namespace: biological_process
def: "The cell cycle process whereby a cell progresses from metaphase to anaphase during mitosis, triggered by the destruction of mitotic cyclins." [PMID:10465783]
xref: Reactome:449063 "Mitotic Metaphase/Anaphase Transition"
xref: Reactome:470176 "Mitotic Metaphase/Anaphase Transition"
xref: Reactome:487862 "Mitotic Metaphase/Anaphase Transition"
xref: Reactome:507833 "Mitotic Metaphase/Anaphase Transition"
xref: Reactome:517874 "Mitotic Metaphase/Anaphase Transition"
xref: Reactome:526700 "Mitotic Metaphase/Anaphase Transition"
xref: Reactome:531473 "Mitotic Metaphase/Anaphase Transition"
xref: Reactome:536858 "Mitotic Metaphase/Anaphase Transition"
xref: Reactome:542611 "Mitotic Metaphase/Anaphase Transition"
xref: Reactome:547929 "Mitotic Metaphase/Anaphase Transition"
xref: Reactome:552506 "Mitotic Metaphase/Anaphase Transition"
xref: Reactome:558136 "Mitotic Metaphase/Anaphase Transition"
xref: Reactome:586014 "Mitotic Metaphase/Anaphase Transition"
xref: Reactome:592869 "Mitotic Metaphase/Anaphase Transition"
xref: Reactome:68881 "Mitotic Metaphase/Anaphase Transition"
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007067 ! mitosis

[Term]
id: GO:0007092
name: activation of anaphase-promoting complex activity during mitotic cell cycle
namespace: biological_process
def: "Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex during the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb, PMID:10871297]
synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during mitotic cell cycle" EXACT []
synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during mitotic cell cycle" EXACT []
synonym: "activation of ubiquitin ligase activity of APC during mitotic cell cycle" EXACT []
synonym: "anaphase promoting complex activation during mitotic cell cycle" EXACT []
synonym: "anaphase-promoting complex activation during mitotic cell cycle" EXACT []
synonym: "APC activation during mitotic cell cycle" EXACT []
synonym: "mitotic anaphase promoting complex activation" EXACT []
synonym: "mitotic anaphase promoting complex activator" NARROW []
synonym: "mitotic anaphase-promoting complex activation" EXACT []
synonym: "mitotic anaphase-promoting complex activator" NARROW []
synonym: "mitotic APC activation" EXACT []
synonym: "mitotic APC activator" NARROW []
xref: Reactome:162659 "Activation of the Anaphase Promoting Complex (APC) by Plk1"
xref: Reactome:163010 "Down Regulation of Emi1 through Phosphorylation of Emi1"
xref: Reactome:429965 "Activation of the Anaphase Promoting Complex (APC) by Plk1"
xref: Reactome:437296 "Down Regulation of Emi1 through Phosphorylation of Emi1"
xref: Reactome:452156 "Activation of the Anaphase Promoting Complex (APC) by Plk1"
xref: Reactome:459414 "Down Regulation of Emi1 through Phosphorylation of Emi1"
xref: Reactome:472746 "Activation of the Anaphase Promoting Complex (APC) by Plk1"
xref: Reactome:478607 "Down Regulation of Emi1 through Phosphorylation of Emi1"
xref: Reactome:491085 "Activation of the Anaphase Promoting Complex (APC) by Plk1"
xref: Reactome:498368 "Down Regulation of Emi1 through Phosphorylation of Emi1"
xref: Reactome:509588 "Activation of the Anaphase Promoting Complex (APC) by Plk1"
xref: Reactome:519353 "Activation of the Anaphase Promoting Complex (APC) by Plk1"
xref: Reactome:527474 "Activation of the Anaphase Promoting Complex (APC) by Plk1"
xref: Reactome:532379 "Activation of the Anaphase Promoting Complex (APC) by Plk1"
xref: Reactome:537849 "Activation of the Anaphase Promoting Complex (APC) by Plk1"
xref: Reactome:543458 "Activation of the Anaphase Promoting Complex (APC) by Plk1"
xref: Reactome:553455 "Activation of the Anaphase Promoting Complex (APC) by Plk1"
xref: Reactome:587317 "Activation of the Anaphase Promoting Complex (APC) by Plk1"
is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0045842 ! positive regulation of mitotic metaphase/anaphase transition
is_a: GO:0051437 ! positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle
is_a: GO:0051488 ! activation of anaphase-promoting complex activity
relationship: positively_regulates GO:0031145 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

[Term]
id: GO:0007093
name: mitotic cell cycle checkpoint
namespace: biological_process
def: "A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mah, GOC:rn, PMID:12360190]
synonym: "mitotic checkpoint" RELATED []
is_a: GO:0000075 ! cell cycle checkpoint
is_a: GO:0007346 ! regulation of mitotic cell cycle

[Term]
id: GO:0007094
name: mitotic cell cycle spindle assembly checkpoint
namespace: biological_process
def: "A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly)." [GOC:rn, PMID:12360190]
synonym: "Mad2-dependent checkpoint" NARROW []
xref: Reactome:448933 "Mitotic Spindle Checkpoint"
xref: Reactome:470050 "Mitotic Spindle Checkpoint"
xref: Reactome:487750 "Mitotic Spindle Checkpoint"
xref: Reactome:507706 "Mitotic Spindle Checkpoint"
xref: Reactome:517642 "Mitotic Spindle Checkpoint"
xref: Reactome:531430 "Mitotic Spindle Checkpoint"
xref: Reactome:536802 "Mitotic Spindle Checkpoint"
xref: Reactome:542561 "Mitotic Spindle Checkpoint"
xref: Reactome:547737 "Mitotic Spindle Checkpoint"
xref: Reactome:552307 "Mitotic Spindle Checkpoint"
xref: Reactome:558048 "Mitotic Spindle Checkpoint"
xref: Reactome:568545 "Mitotic Spindle Checkpoint"
xref: Reactome:581756 "Mitotic Spindle Checkpoint"
xref: Reactome:592669 "Mitotic Spindle Checkpoint"
xref: Reactome:69618 "Mitotic Spindle Checkpoint"
is_a: GO:0007093 ! mitotic cell cycle checkpoint
is_a: GO:0045841 ! negative regulation of mitotic metaphase/anaphase transition
is_a: GO:0071173 ! spindle assembly checkpoint
is_a: GO:0071174 ! mitotic cell cycle spindle checkpoint

[Term]
id: GO:0007095
name: mitotic cell cycle G2/M transition DNA damage checkpoint
namespace: biological_process
def: "A signal transduction-based surveillance mechanism that acts during a mitotic cell cycle to ensure accurate chromosome segregation by preventing entry into mitosis in the presence of damaged DNA." [GOC:mah, PMID:10856933, PMID:11406266]
synonym: "mitotic G2 checkpoint" RELATED []
is_a: GO:0031572 ! G2/M transition DNA damage checkpoint

[Term]
id: GO:0007096
name: regulation of exit from mitosis
namespace: biological_process
def: "Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0010458 ! exit from mitosis

[Term]
id: GO:0007097
name: nuclear migration
namespace: biological_process
def: "The directed movement of the nucleus." [GOC:ai]
synonym: "nucleus migration" EXACT []
is_a: GO:0040023 ! establishment of nucleus localization

[Term]
id: GO:0007098
name: centrosome cycle
namespace: biological_process
def: "The cell cycle process whereby centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051297 ! centrosome organization

[Term]
id: GO:0007099
name: centriole replication
namespace: biological_process
def: "The cell cycle process whereby a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194]
synonym: "centriole duplication" EXACT []
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051298 ! centrosome duplication

[Term]
id: GO:0007100
name: mitotic centrosome separation
namespace: biological_process
def: "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194]
is_a: GO:0051299 ! centrosome separation

[Term]
id: GO:0007101
name: male meiosis centrosome cycle
namespace: biological_process
def: "Centrosome duplication and separation in the context of male meiosis." [GOC:mah]
is_a: GO:0007098 ! centrosome cycle

[Term]
id: GO:0007103
name: spindle pole body duplication in nuclear envelope
namespace: biological_process
def: "Construction of a new spindle pole body adjacent to the existing spindle pole body in the nuclear envelope; usually occurs about the time of bud emergence. An example of this is found in Saccharomyces cerevisiae." [ISBN:0879693649]
is_a: GO:0030474 ! spindle pole body duplication

[Term]
id: GO:0007105
name: cytokinesis, site selection
namespace: biological_process
def: "The process of marking the place where cytokinesis will occur." [GOC:clt, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "actomyosin ring positioning" NARROW []
synonym: "contractile ring positioning" NARROW []
synonym: "site selection involved in cytokinesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032506 ! cytokinetic process

[Term]
id: GO:0007106
name: cytokinesis, protein recruitment
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was not defined.
is_obsolete: true

[Term]
id: GO:0007107
name: membrane addition at site of cytokinesis
namespace: biological_process
def: "Any process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion." [GOC:clt]
synonym: "cytokinesis, membrane recruitment/generation" EXACT []
is_a: GO:0016044 ! cellular membrane organization
is_a: GO:0032506 ! cytokinetic process

[Term]
id: GO:0007108
name: cytokinesis, initiation of separation
namespace: biological_process
def: "The process involved in starting cell separation." [GOC:clt, GOC:dph, GOC:tb]
synonym: "initiation of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0000920 ! cell separation during cytokinesis

[Term]
id: GO:0007109
name: cytokinesis, completion of separation
namespace: biological_process
def: "The process of finishing cell separation, which results in two physically separated cells." [GOC:clt, GOC:dph, GOC:tb]
synonym: "completion of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0000920 ! cell separation during cytokinesis

[Term]
id: GO:0007110
name: cytokinesis after meiosis I
namespace: biological_process
def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:ai]
is_a: GO:0033206 ! cytokinesis after meiosis

[Term]
id: GO:0007111
name: cytokinesis after meiosis II
namespace: biological_process
def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:ai]
is_a: GO:0033206 ! cytokinesis after meiosis

[Term]
id: GO:0007112
name: male meiosis cytokinesis
namespace: biological_process
def: "A cell cycle process that occurs during male meiosis and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai]
is_a: GO:0033206 ! cytokinesis after meiosis

[Term]
id: GO:0007113
name: endomitotic cell cycle
namespace: biological_process
def: "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm]
synonym: "endomitosis" EXACT []
xref: Wikipedia:Mitosis#Endomitosis
is_a: GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007114
name: cell budding
namespace: biological_process
def: "A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_yeast
subset: gosubset_prok
synonym: "budding" BROAD []
is_a: GO:0019954 ! asexual reproduction
is_a: GO:0032505 ! reproduction of a single-celled organism
is_a: GO:0051301 ! cell division

[Term]
id: GO:0007115
name: bud site selection/establishment of cell polarity (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents two processes.
is_obsolete: true
consider: GO:0000282
consider: GO:0030010

[Term]
id: GO:0007116
name: regulation of cell budding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation and growth of cell buds." [GOC:mah]
synonym: "regulation of budding" BROAD []
is_a: GO:0051302 ! regulation of cell division
relationship: regulates GO:0007114 ! cell budding

[Term]
id: GO:0007117
name: budding cell bud growth
namespace: biological_process
def: "The process by which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:go_curators]
synonym: "bud growth" BROAD []
is_a: GO:0022413 ! reproductive process in single-celled organism
is_a: GO:0048590 ! non-developmental growth
relationship: part_of GO:0007114 ! cell budding

[Term]
id: GO:0007118
name: budding cell apical bud growth
namespace: biological_process
def: "Growth at the tip of a bud, in a cell that reproduces by budding." [GOC:go_curators]
synonym: "apical bud growth" BROAD []
is_a: GO:0007117 ! budding cell bud growth

[Term]
id: GO:0007119
name: budding cell isotropic bud growth
namespace: biological_process
def: "Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding." [GOC:go_curators]
synonym: "isotropic bud growth" BROAD []
is_a: GO:0007117 ! budding cell bud growth

[Term]
id: GO:0007120
name: axial cellular bud site selection
namespace: biological_process
def: "The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell." [GOC:clt]
synonym: "axial bud site selection" EXACT []
synonym: "axial budding" BROAD []
is_a: GO:0000282 ! cellular bud site selection
is_a: GO:0007114 ! cell budding

[Term]
id: GO:0007121
name: bipolar cellular bud site selection
namespace: biological_process
def: "The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell." [GOC:clt]
synonym: "bipolar bud site selection" EXACT []
synonym: "bipolar budding" BROAD []
synonym: "polar budding" BROAD []
is_a: GO:0000282 ! cellular bud site selection
is_a: GO:0007114 ! cell budding

[Term]
id: GO:0007122
name: loss of asymmetric budding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is a phenotype rather than a biological process.
is_obsolete: true
consider: GO:0006033

[Term]
id: GO:0007123
name: bud scar accumulation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is a phenotype rather than a biological process.
is_obsolete: true
consider: GO:0000282

[Term]
id: GO:0007124
name: pseudohyphal growth
namespace: biological_process
def: "A pattern of cell growth that occurs in conditions of nitrogen limitation and abundant fermentable carbon source. Cells become elongated, switch to a unipolar budding pattern, remain physically attached to each other, and invade the growth substrate." [GOC:krc, PMID:11104818]
subset: goslim_candida
subset: goslim_yeast
is_a: GO:0016049 ! cell growth
is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells

[Term]
id: GO:0007125
name: invasive growth
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it has been split into two new terms.
is_obsolete: true
consider: GO:0001403
consider: GO:0044409

[Term]
id: GO:0007126
name: meiosis
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle, the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiotic division occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations." [GOC:dph, GOC:mah, PMID:9334324]
subset: goslim_pombe
subset: goslim_yeast
xref: Wikipedia:Meiosis
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0051327 ! M phase of meiotic cell cycle

[Term]
id: GO:0007127
name: meiosis I
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:mah, PMID:9334324]
xref: Wikipedia:Meiosis#Meiosis_I
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0007126 ! meiosis

[Term]
id: GO:0007128
name: meiotic prophase I
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through prophase of meiosis I; divided into several stages." [GOC:dph, GOC:mah]
is_a: GO:0051324 ! prophase
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0007129
name: synapsis
namespace: biological_process
def: "The cell cycle process whereby the side by side pairing and physical juxtaposition of homologous chromosomes is created at the metaphase plate." [GOC:elh]
synonym: "chromosomal pairing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "chromosomal synapsis" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "homologous chromosome pairing at meiosis" EXACT []
xref: Wikipedia:Synapsis
is_a: GO:0070192 ! chromosome organization involved in meiosis
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0007130
name: synaptonemal complex assembly
namespace: biological_process
def: "The cell cycle process whereby the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "synaptonemal complex formation" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0070192 ! chromosome organization involved in meiosis
is_a: GO:0070193 ! synaptonemal complex organization
relationship: part_of GO:0007129 ! synapsis

[Term]
id: GO:0007131
name: reciprocal meiotic recombination
namespace: biological_process
alt_id: GO:0000021
alt_id: GO:0007145
def: "The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779]
synonym: "female meiotic recombination" NARROW []
synonym: "gene conversion with reciprocal crossover" EXACT []
is_a: GO:0006310 ! DNA recombination
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0007132
name: meiotic metaphase I
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through metaphase of meiosis I; analogous to mitotic metaphase." [GOC:dph, GOC:mah]
is_a: GO:0051323 ! metaphase
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0007133
name: meiotic anaphase I
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through anaphase of meiosis I; analogous to mitotic anaphase." [GOC:dph, GOC:mah]
is_a: GO:0051322 ! anaphase
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0007134
name: meiotic telophase I
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through telophase of meiosis I; analogous to mitotic telophase." [GOC:dph, GOC:mah]
is_a: GO:0051326 ! telophase
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0007135
name: meiosis II
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through the second phase of meiosis, in which cells divide and separate the two chromatids in each chromosome." [GOC:dph, GOC:mah, ISBN:0198547684]
xref: Wikipedia:Meiosis#Meiosis_II
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0007126 ! meiosis

[Term]
id: GO:0007136
name: meiotic prophase II
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through prophase of meiosis II; analogous to mitotic prophase." [GOC:dph, GOC:mah]
is_a: GO:0051324 ! prophase
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0007137
name: meiotic metaphase II
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through metaphase of meiosis II; analogous to mitotic metaphase." [GOC:dph, GOC:mah]
is_a: GO:0051323 ! metaphase
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0007138
name: meiotic anaphase II
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through anaphase of meiosis II; analogous to mitotic anaphase." [GOC:dph, GOC:mah]
is_a: GO:0051322 ! anaphase
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0007139
name: meiotic telophase II
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through telophase of meiosis II; analogous to mitotic telophase." [GOC:dph, GOC:mah]
is_a: GO:0051326 ! telophase
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0007140
name: male meiosis
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah]
is_a: GO:0007126 ! meiosis

[Term]
id: GO:0007141
name: male meiosis I
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah]
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0007140 ! male meiosis

[Term]
id: GO:0007142
name: male meiosis II
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline." [GOC:dph, GOC:mah]
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0007140 ! male meiosis

[Term]
id: GO:0007143
name: female meiosis
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah]
comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiosis ; GO:0007126'.
is_a: GO:0007126 ! meiosis

[Term]
id: GO:0007144
name: female meiosis I
namespace: biological_process
def: "The cell cycle process whereby the first meiotic division occurs in the female germline." [GOC:mah]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007143 ! female meiosis

[Term]
id: GO:0007146
name: meiotic recombination nodule assembly
namespace: biological_process
def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes." [GOC:jl, PMID:9334324]
is_a: GO:0000707 ! meiotic DNA recombinase assembly

[Term]
id: GO:0007147
name: female meiosis II
namespace: biological_process
def: "The cell cycle process whereby the second meiotic division occurs in the female germline." [GOC:mah]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007143 ! female meiosis

[Term]
id: GO:0007149
name: colony morphology
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it describes a phenotype rather than a biological goal.
is_obsolete: true

[Term]
id: GO:0007150
name: growth pattern
namespace: biological_process
def: "OBSOLETE. A process whereby cells develop a specific morphology under a specific set of circumstances." [GOC:jic]
comment: This term was made obsolete because the original meaning of the term is unclear, the current definition is incorrect, and it does not describe a biological process.
is_obsolete: true
consider: GO:0040007

[Term]
id: GO:0007154
name: cell communication
namespace: biological_process
def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah]
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
xref: Wikipedia:Cell_signaling
is_a: GO:0009987 ! cellular process
is_a: GO:0023052 ! signaling

[Term]
id: GO:0007155
name: cell adhesion
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf]
subset: goslim_candida
subset: goslim_pir
subset: goslim_pombe
subset: gosubset_prok
synonym: "cell adhesion molecule activity" RELATED []
xref: Wikipedia:Cell_adhesion
is_a: GO:0009987 ! cellular process
is_a: GO:0022610 ! biological adhesion

[Term]
id: GO:0007156
name: homophilic cell adhesion
namespace: biological_process
def: "The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0016337 ! cell-cell adhesion

[Term]
id: GO:0007157
name: heterophilic cell adhesion
namespace: biological_process
def: "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "agglutination" RELATED [GOC:mah]
is_a: GO:0016337 ! cell-cell adhesion

[Term]
id: GO:0007158
name: neuron adhesion
namespace: biological_process
def: "The attachment of a neuron to another cell via adhesion molecules." [GOC:go_curators]
synonym: "neuronal cell adhesion" EXACT []
is_a: GO:0016337 ! cell-cell adhesion

[Term]
id: GO:0007159
name: leukocyte adhesion
namespace: biological_process
def: "The attachment of a leukocyte to another cell via adhesion molecules." [GOC:go_curators]
synonym: "leukocyte cell adhesion" EXACT []
is_a: GO:0016337 ! cell-cell adhesion

[Term]
id: GO:0007160
name: cell-matrix adhesion
namespace: biological_process
def: "The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb]
subset: gosubset_prok
is_a: GO:0031589 ! cell-substrate adhesion

[Term]
id: GO:0007161
name: calcium-independent cell-matrix adhesion
namespace: biological_process
def: "The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb]
synonym: "calcium-independent cell adhesion molecule activity" RELATED []
is_a: GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0007162
name: negative regulation of cell adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators]
synonym: "cell adhesion receptor inhibitor activity" RELATED []
synonym: "down regulation of cell adhesion" EXACT []
synonym: "down-regulation of cell adhesion" EXACT []
synonym: "downregulation of cell adhesion" EXACT []
synonym: "inhibition of cell adhesion" NARROW []
is_a: GO:0030155 ! regulation of cell adhesion
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0007155 ! cell adhesion

[Term]
id: GO:0007163
name: establishment or maintenance of cell polarity
namespace: biological_process
alt_id: GO:0030012
alt_id: GO:0030467
def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
subset: goslim_pombe
synonym: "establishment and/or maintenance of cell polarity" RELATED []
synonym: "establishment and/or maintenance of cell polarization" RELATED []
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0000902 ! cell morphogenesis

[Term]
id: GO:0007164
name: establishment of tissue polarity
namespace: biological_process
def: "Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jic]
is_a: GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0007165
name: signal transduction
namespace: biological_process
def: "The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell." [GOC:go_curators]
comment: Note that in many cases the end of this process is the initiation of transcription.
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "signaling cascade" EXACT []
synonym: "signalling cascade" EXACT []
xref: Reactome:212718 "EGFR interacts with phospholipase C-gamma"
xref: Reactome:448734 "EGFR interacts with phospholipase C-gamma"
xref: Reactome:469856 "EGFR interacts with phospholipase C-gamma"
xref: Reactome:487553 "EGFR interacts with phospholipase C-gamma"
xref: Reactome:507509 "EGFR interacts with phospholipase C-gamma"
xref: Wikipedia:Signal_transduction
is_a: GO:0023060 ! signal transmission
is_a: GO:0050794 ! regulation of cellular process

[Term]
id: GO:0007166
name: cell surface receptor linked signaling pathway
namespace: biological_process
def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell." [GOC:mah]
subset: gosubset_prok
synonym: "cell surface receptor linked signal transduction" EXACT []
xref: Reactome:110437 "DILP binds to Drosophila insulin receptor (DINR)"
is_a: GO:0023033 ! signaling pathway

[Term]
id: GO:0007167
name: enzyme linked receptor protein signaling pathway
namespace: biological_process
def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase." [GOC:mah, ISBN:0185316194]
synonym: "enzyme linked receptor protein signalling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor linked signaling pathway
is_a: GO:0023034 ! intracellular signaling pathway

[Term]
id: GO:0007168
name: receptor guanylyl cyclase signaling pathway
namespace: biological_process
def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses guanylyl cyclase activity." [GOC:mah]
synonym: "receptor guanylyl cyclase signalling pathway" EXACT []
is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway

[Term]
id: GO:0007169
name: transmembrane receptor protein tyrosine kinase signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand." [GOC:ceb]
synonym: "transmembrane receptor protein tyrosine kinase signalling pathway" EXACT []
xref: Reactome:187015 "Activation of TRKA receptors"
xref: Reactome:448666 "Activation of TRKA receptors"
xref: Reactome:469794 "Activation of TRKA receptors"
xref: Reactome:487488 "Activation of TRKA receptors"
xref: Reactome:507448 "Activation of TRKA receptors"
is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway

[Term]
id: GO:0007170
name: transmembrane receptor protein tyrosine kinase ligand binding
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a function rather than a process.
is_obsolete: true
consider: GO:0030971

[Term]
id: GO:0007171
name: activation of transmembrane receptor protein tyrosine kinase activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity." [GOC:dph, GOC:tb]
synonym: "transmembrane receptor protein tyrosine kinase activation" RELATED [GOC:dph, GOC:tb]
synonym: "transmembrane receptor protein tyrosine kinase dimerization" RELATED [GOC:dph, GOC:mtg_lung]
is_a: GO:0032147 ! activation of protein kinase activity
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0007172
name: signal complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell. Complex formation involves dimerization of a receptor protein tyrosine kinase followed by the association of several different intracellular signaling molecules with the cytoplasmic tails of the receptors." [PMID:9646862]
synonym: "signal complex formation" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0007173
name: epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands." [GOC:ceb]
synonym: "EGF receptor signaling pathway" EXACT []
synonym: "EGF receptor signalling pathway" EXACT []
synonym: "EGFR signaling pathway" EXACT []
synonym: "epidermal growth factor receptor signalling pathway" EXACT []
xref: Reactome:177929 "Signaling by EGFR"
xref: Reactome:448655 "Signaling by EGFR"
xref: Reactome:469783 "Signaling by EGFR"
xref: Reactome:487477 "Signaling by EGFR"
xref: Reactome:507437 "Signaling by EGFR"
xref: Reactome:517441 "Signaling by EGFR"
xref: Reactome:526315 "Signaling by EGFR"
xref: Reactome:531365 "Signaling by EGFR"
xref: Reactome:536741 "Signaling by EGFR"
xref: Reactome:542490 "Signaling by EGFR"
xref: Reactome:547817 "Signaling by EGFR"
xref: Reactome:552385 "Signaling by EGFR"
xref: Reactome:557990 "Signaling by EGFR"
xref: Reactome:568641 "Signaling by EGFR"
xref: Reactome:581845 "Signaling by EGFR"
xref: Reactome:592751 "Signaling by EGFR"
xref: Reactome:595486 "Signaling by EGFR"
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0007174
name: epidermal growth factor ligand processing
namespace: biological_process
def: "The proteolysis of epidermal growth factor after its internalization via binding to its receptor." [GOC:isa_complete, PMID:2985587]
synonym: "EGF receptor ligand processing" EXACT []
is_a: GO:0051605 ! protein maturation by peptide bond cleavage
relationship: part_of GO:0007173 ! epidermal growth factor receptor signaling pathway

[Term]
id: GO:0007175
name: negative regulation of epidermal growth factor receptor activity
namespace: biological_process
alt_id: GO:0007177
def: "Any process that stops, prevents or reduces the frequency, rate or extent of EGF receptor activity." [GOC:go_curators]
synonym: "down regulation of epidermal growth factor receptor activity" EXACT []
synonym: "down-regulation of epidermal growth factor receptor activity" EXACT []
synonym: "downregulation of epidermal growth factor receptor activity" EXACT []
synonym: "EGF receptor downregulation" EXACT []
synonym: "inhibition of epidermal growth factor receptor activity" NARROW []
synonym: "negative regulation of EGF receptor activity" EXACT []
synonym: "negative regulation of EGFR activity" EXACT []
is_a: GO:0006469 ! negative regulation of protein kinase activity
is_a: GO:0007176 ! regulation of epidermal growth factor receptor activity
is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway

[Term]
id: GO:0007176
name: regulation of epidermal growth factor receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of EGF receptor activity." [GOC:dph, GOC:go_curators]
synonym: "regulation of EGF receptor activity" EXACT []
synonym: "regulation of EGFR activity" EXACT []
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway
is_a: GO:0045859 ! regulation of protein kinase activity

[Term]
id: GO:0007178
name: transmembrane receptor protein serine/threonine kinase signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:mah]
synonym: "transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT []
is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway

[Term]
id: GO:0007179
name: transforming growth factor beta receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "TGF-beta receptor signaling pathway" EXACT []
synonym: "TGF-beta receptor signalling pathway" EXACT []
synonym: "TGFbeta receptor signaling pathway" EXACT []
synonym: "TGFbeta receptor signalling pathway" EXACT []
synonym: "transforming growth factor beta receptor signalling pathway" EXACT []
xref: Reactome:170834 "Signaling by TGF beta"
xref: Reactome:448667 "Signaling by TGF beta"
xref: Reactome:469795 "Signaling by TGF beta"
xref: Reactome:487489 "Signaling by TGF beta"
xref: Reactome:507449 "Signaling by TGF beta"
xref: Reactome:517861 "Signaling by TGF beta"
is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0007180
name: transforming growth factor beta ligand binding to type II receptor
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a function.
synonym: "TGF-beta ligand binding to type II receptor" EXACT []
synonym: "TGFbeta ligand binding to type II receptor" EXACT []
is_obsolete: true
consider: GO:0005026
consider: GO:0005160
consider: GO:0050431

[Term]
id: GO:0007181
name: transforming growth factor beta receptor complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex." [GOC:jl, Reactome:REACT_7425, Wikipedia:TGF_beta_signaling_pathway]
synonym: "TGF-beta receptor complex assembly" EXACT []
synonym: "TGF-beta:type II receptor:type I receptor complex assembly" EXACT []
synonym: "TGFbeta receptor complex assembly" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0007179 ! transforming growth factor beta receptor signaling pathway

[Term]
id: GO:0007182
name: common-partner SMAD protein phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus." [GOC:dph, ISBN:3527303782]
synonym: "common mediator SMAD protein phosphorylation" EXACT []
is_a: GO:0006468 ! protein amino acid phosphorylation
relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0007183
name: SMAD protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:isa_complete]
synonym: "SMAD protein heteromerization" NARROW [GOC:mah, PMID:9670020]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0007184
name: SMAD protein nuclear translocation
namespace: biological_process
def: "The vectorial transfer of a SMAD proteins from the cytoplasm into the nucleus, through the nuclear pore. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph]
synonym: "SMAD protein import into nucleus, translocation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000060 ! protein import into nucleus, translocation
relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0007185
name: transmembrane receptor protein tyrosine phosphatase signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine phosphatase binding to its physiological ligand." [GOC:mah]
synonym: "transmembrane receptor protein tyrosine phosphatase signalling pathway" EXACT []
is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway

[Term]
id: GO:0007186
name: G-protein coupled receptor protein signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GOC:mah]
synonym: "G protein coupled receptor protein signaling pathway" EXACT []
synonym: "G protein coupled receptor protein signalling pathway" EXACT []
synonym: "G-protein coupled receptor protein signal transduction" EXACT []
synonym: "G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "G-protein-coupled receptor protein signaling pathway" EXACT []
synonym: "G-protein-coupled receptor protein signalling pathway" EXACT []
synonym: "GPCR protein signaling pathway" EXACT []
synonym: "GPCR protein signalling pathway" EXACT []
xref: Reactome:379046 "Receptor-ligand complexes bind G proteins"
is_a: GO:0007166 ! cell surface receptor linked signaling pathway

[Term]
id: GO:0007187
name: G-protein signaling, coupled to cyclic nucleotide second messenger
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide." [GOC:mah, ISBN:0815316194]
synonym: "G protein signaling, coupled to cyclic nucleotide second messenger" EXACT []
synonym: "G protein signalling, coupled to cyclic nucleotide second messenger" EXACT []
synonym: "G-protein signalling, coupled to cyclic nucleotide second messenger" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway
is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling

[Term]
id: GO:0007188
name: G-protein signaling, coupled to cAMP nucleotide second messenger
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP." [GOC:mah, ISBN:0815316194]
synonym: "G protein signaling, coupled to cAMP nucleotide second messenger" EXACT []
synonym: "G protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT []
synonym: "G protein signalling, coupled to cAMP nucleotide second messenger" EXACT []
synonym: "G protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT []
synonym: "G-protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT []
synonym: "G-protein signalling, coupled to cAMP nucleotide second messenger" EXACT []
synonym: "G-protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT []
is_a: GO:0007187 ! G-protein signaling, coupled to cyclic nucleotide second messenger
is_a: GO:0019933 ! cAMP-mediated signaling

[Term]
id: GO:0007189
name: activation of adenylate cyclase activity by G-protein signaling pathway
namespace: biological_process
alt_id: GO:0010580
def: "Any process that initiates the activity of an inactive adenylate cyclase that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb, ISBN:0815316194]
synonym: "activation of adenylate cyclase activity involved in G-protein signaling" EXACT []
synonym: "G protein signaling, adenylate cyclase activating pathway" EXACT []
synonym: "G protein signaling, adenylyl cyclase activating pathway" EXACT []
synonym: "G protein signalling, adenylate cyclase activating pathway" EXACT []
synonym: "G protein signalling, adenylyl cyclase activating pathway" EXACT []
synonym: "G-protein signaling, adenylate cyclase activating pathway" EXACT [GOC:dph, GOC:tb]
synonym: "G-protein signaling, adenylyl cyclase activating pathway" EXACT []
synonym: "G-protein signalling, adenylate cyclase activating pathway" EXACT []
synonym: "G-protein signalling, adenylyl cyclase activating pathway" EXACT []
xref: Reactome:170660 "Adenylate cyclase activating pathway"
xref: Reactome:448755 "Adenylate cyclase activating pathway"
xref: Reactome:469870 "Adenylate cyclase activating pathway"
xref: Reactome:487574 "Adenylate cyclase activating pathway"
xref: Reactome:507530 "Adenylate cyclase activating pathway"
xref: Reactome:517513 "Adenylate cyclase activating pathway"
xref: Reactome:526382 "Adenylate cyclase activating pathway"
is_a: GO:0007188 ! G-protein signaling, coupled to cAMP nucleotide second messenger
is_a: GO:0007190 ! activation of adenylate cyclase activity
is_a: GO:0010579 ! positive regulation of adenylate cyclase activity by G-protein signaling pathway

[Term]
id: GO:0007190
name: activation of adenylate cyclase activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme adenylate cyclase." [GOC:ai]
synonym: "adenylate cyclase activation" EXACT [GOC:dph, GOC:tb]
synonym: "adenylate cyclase activator" RELATED []
synonym: "adenylyl cyclase activation" EXACT []
xref: Reactome:170672 "Galpha-olf:GTP binds to adenylate cyclase and activates it"
xref: Reactome:187024 "NGF-independant TRKA activation"
xref: Reactome:439261 "Galpha-olf:GTP binds to adenylate cyclase and activates it"
xref: Reactome:448937 "NGF-independant TRKA activation"
xref: Reactome:461259 "Galpha-olf:GTP binds to adenylate cyclase and activates it"
xref: Reactome:470055 "NGF-independant TRKA activation"
xref: Reactome:480037 "Galpha-olf:GTP binds to adenylate cyclase and activates it"
xref: Reactome:487752 "NGF-independant TRKA activation"
xref: Reactome:499933 "Galpha-olf:GTP binds to adenylate cyclase and activates it"
xref: Reactome:507710 "NGF-independant TRKA activation"
xref: Reactome:513846 "Galpha-olf:GTP binds to adenylate cyclase and activates it"
xref: Reactome:522840 "Galpha-olf:GTP binds to adenylate cyclase and activates it"
is_a: GO:0045762 ! positive regulation of adenylate cyclase activity

[Term]
id: GO:0007191
name: activation of adenylate cyclase activity by dopamine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP." [GOC:mah]
synonym: "activation of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:mah]
synonym: "dopamine receptor, adenylate cyclase activating pathway" EXACT [GOC:dph, GOC:tb]
synonym: "dopamine receptor, adenylyl cyclase activating pathway" EXACT []
is_a: GO:0007189 ! activation of adenylate cyclase activity by G-protein signaling pathway
is_a: GO:0007212 ! dopamine receptor signaling pathway
is_a: GO:0023050 ! consequence of signal transmission

[Term]
id: GO:0007192
name: activation of adenylate cyclase activity by serotonin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of adenylate cyclase activity by serotonin receptor signalling pathway" EXACT [GOC:mah]
synonym: "serotonin receptor, adenylate cyclase activating pathway" RELATED [GOC:dph, GOC:tb]
synonym: "serotonin receptor, adenylyl cyclase activating pathway" EXACT []
is_a: GO:0007189 ! activation of adenylate cyclase activity by G-protein signaling pathway
is_a: GO:0007210 ! serotonin receptor signaling pathway

[Term]
id: GO:0007193
name: inhibition of adenylate cyclase activity by G-protein signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb, ISBN:0815316194]
synonym: "G protein signaling, adenylate cyclase inhibiting pathway" EXACT []
synonym: "G protein signaling, adenylyl cyclase inhibiting pathway" EXACT []
synonym: "G protein signalling, adenylate cyclase inhibiting pathway" EXACT []
synonym: "G protein signalling, adenylyl cyclase inhibiting pathway" EXACT []
synonym: "G-protein signaling, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
synonym: "G-protein signaling, adenylyl cyclase inhibiting pathway" EXACT []
synonym: "G-protein signalling, adenylate cyclase inhibiting pathway" EXACT []
synonym: "G-protein signalling, adenylyl cyclase inhibiting pathway" EXACT []
xref: Reactome:170670 "Adenylate cyclase inhibitory pathway"
xref: Reactome:448756 "Adenylate cyclase inhibitory pathway"
xref: Reactome:469871 "Adenylate cyclase inhibitory pathway"
xref: Reactome:487575 "Adenylate cyclase inhibitory pathway"
xref: Reactome:507531 "Adenylate cyclase inhibitory pathway"
xref: Reactome:517514 "Adenylate cyclase inhibitory pathway"
xref: Reactome:526383 "Adenylate cyclase inhibitory pathway"
xref: Reactome:558055 "Adenylate cyclase inhibitory pathway"
xref: Reactome:581903 "Adenylate cyclase inhibitory pathway"
xref: Reactome:592801 "Adenylate cyclase inhibitory pathway"
is_a: GO:0007188 ! G-protein signaling, coupled to cAMP nucleotide second messenger
is_a: GO:0007194 ! negative regulation of adenylate cyclase activity

[Term]
id: GO:0007194
name: negative regulation of adenylate cyclase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]
synonym: "adenylate cyclase inhibitor" RELATED []
synonym: "down regulation of adenylate cyclase activity" EXACT []
synonym: "down-regulation of adenylate cyclase activity" EXACT []
synonym: "downregulation of adenylate cyclase activity" EXACT []
synonym: "inhibition of adenylate cyclase activity" NARROW []
synonym: "negative regulation of adenylyl cyclase activity" EXACT []
is_a: GO:0031280 ! negative regulation of cyclase activity
is_a: GO:0045761 ! regulation of adenylate cyclase activity
is_a: GO:0051350 ! negative regulation of lyase activity

[Term]
id: GO:0007195
name: inhibition of adenylate cyclase activity by dopamine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb]
synonym: "dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
synonym: "dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT []
synonym: "inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0007193 ! inhibition of adenylate cyclase activity by G-protein signaling pathway
is_a: GO:0007212 ! dopamine receptor signaling pathway
is_a: GO:0023050 ! consequence of signal transmission

[Term]
id: GO:0007196
name: inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a metabotropic glutamate receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb]
synonym: "inhibition of adenylate cyclase activity by metabotropic glutamate receptor signalling pathway" EXACT [GOC:mah]
synonym: "metabotropic glutamate receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
synonym: "metabotropic glutamate receptor, adenylyl cyclase inhibiting pathway" EXACT []
is_a: GO:0007193 ! inhibition of adenylate cyclase activity by G-protein signaling pathway
is_a: GO:0007216 ! metabotropic glutamate receptor signaling pathway

[Term]
id: GO:0007197
name: inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb]
synonym: "inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signalling pathway" EXACT [GOC:mah]
synonym: "muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
synonym: "muscarinic acetylcholine receptor, adenylyl cyclase inhibiting pathway" EXACT []
is_a: GO:0007193 ! inhibition of adenylate cyclase activity by G-protein signaling pathway
is_a: GO:0007213 ! muscarinic acetylcholine receptor signaling pathway

[Term]
id: GO:0007198
name: inhibition of adenylate cyclase activity by serotonin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb]
synonym: "inhibition of adenylate cyclase activity by serotonin receptor signalling pathway" EXACT [GOC:mah]
synonym: "serotonin receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
synonym: "serotonin receptor, adenylyl cyclase inhibiting pathway" EXACT []
is_a: GO:0007193 ! inhibition of adenylate cyclase activity by G-protein signaling pathway
is_a: GO:0007210 ! serotonin receptor signaling pathway

[Term]
id: GO:0007199
name: G-protein signaling, coupled to cGMP nucleotide second messenger
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase and a subsequent increase in the concentration of cyclic GMP." [GOC:mah, ISBN:0815316194]
synonym: "G protein signaling, coupled to cGMP nucleotide second messenger" EXACT []
synonym: "G protein signalling, coupled to cGMP nucleotide second messenger" EXACT []
synonym: "G-protein signalling, coupled to cGMP nucleotide second messenger" EXACT []
is_a: GO:0007187 ! G-protein signaling, coupled to cyclic nucleotide second messenger
is_a: GO:0019934 ! cGMP-mediated signaling

[Term]
id: GO:0007200
name: activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:mah, GOC:tb, ISBN:0815316194]
synonym: "G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT []
synonym: "G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT []
synonym: "G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:dph, GOC:tb]
synonym: "G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT []
synonym: "phospholipase C-activating dopamine receptor signaling pathway" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway
is_a: GO:0007202 ! activation of phospholipase C activity
is_a: GO:0048015 ! phosphoinositide-mediated signaling

[Term]
id: GO:0007201
name: G-protein dissociation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the dissociation of heterotrimeric G protein subunits is a consequence of a conformational change, which is in turn a consequence of ligand binding; it does not require multiple activities specifically to bring about.
is_obsolete: true

[Term]
id: GO:0007202
name: activation of phospholipase C activity
namespace: biological_process
def: "The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GOC:dph, GOC:mah, GOC:tb, PMID:8280098]
comment: Note that this term refers to a signaling pathway, and should not be confused with function terms such as 'phospholipase activator activity ; GO:0016004'.
synonym: "phospholipase C activation" EXACT [GOC:dph, GOC:tb]
xref: Reactome:167021 "PLC-gamma1 signalling"
xref: Reactome:448735 "PLC-gamma1 signalling"
xref: Reactome:469857 "PLC-gamma1 signalling"
xref: Reactome:487554 "PLC-gamma1 signalling"
xref: Reactome:507510 "PLC-gamma1 signalling"
xref: Reactome:517494 "PLC-gamma1 signalling"
xref: Reactome:526363 "PLC-gamma1 signalling"
xref: Reactome:531294 "PLC-gamma1 signalling"
xref: Reactome:536670 "PLC-gamma1 signalling"
xref: Reactome:542403 "PLC-gamma1 signalling"
xref: Reactome:547752 "PLC-gamma1 signalling"
xref: Reactome:552322 "PLC-gamma1 signalling"
xref: Reactome:557821 "PLC-gamma1 signalling"
xref: Reactome:568560 "PLC-gamma1 signalling"
xref: Reactome:581651 "PLC-gamma1 signalling"
xref: Reactome:585883 "PLC-gamma1 signalling"
xref: Reactome:592563 "PLC-gamma1 signalling"
xref: Reactome:595383 "PLC-gamma1 signalling"
is_a: GO:0010863 ! positive regulation of phospholipase C activity

[Term]
id: GO:0007203
name: phosphatidylinositol-4,5-bisphosphate hydrolysis
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because hydrolysis is a reaction, not a process.
is_obsolete: true
consider: GO:0004435

[Term]
id: GO:0007204
name: elevation of cytosolic calcium ion concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the cytosol." [GOC:ai]
synonym: "cytoplasmic calcium ion concentration elevation" BROAD []
synonym: "cytosolic calcium ion concentration elevation" EXACT []
synonym: "elevation of calcium ion concentration in cytoplasm" BROAD []
synonym: "elevation of calcium ion concentration in cytosol" EXACT []
synonym: "elevation of cytoplasmic calcium ion concentration" BROAD []
is_a: GO:0051480 ! cytosolic calcium ion homeostasis

[Term]
id: GO:0007205
name: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
namespace: biological_process
def: "The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GOC:mah]
synonym: "activation of protein kinase C activity by G-protein coupled receptor protein signalling pathway" EXACT [GOC:mah]
synonym: "PKC activation" EXACT []
synonym: "protein kinase C activation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway
is_a: GO:0032147 ! activation of protein kinase activity

[Term]
id: GO:0007206
name: activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a metabotropic glutamate receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of phospholipase C activity by metabotropic glutamate receptor signalling pathway" EXACT [GOC:mah]
synonym: "metabotropic glutamate receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
is_a: GO:0007216 ! metabotropic glutamate receptor signaling pathway

[Term]
id: GO:0007207
name: activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of phospholipase C activity by muscarinic acetylcholine receptor signalling pathway" EXACT [GOC:mah]
synonym: "muscarinic acetylcholine receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
is_a: GO:0007213 ! muscarinic acetylcholine receptor signaling pathway

[Term]
id: GO:0007208
name: activation of phospholipase C activity by serotonin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of phospholipase C activity by serotonin receptor signalling pathway" EXACT [GOC:mah]
synonym: "serotonin receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
is_a: GO:0007210 ! serotonin receptor signaling pathway

[Term]
id: GO:0007209
name: activation of phospholipase C activity by tachykinin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a tachykinin receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of phospholipase C activity by tachykinin receptor signalling pathway" EXACT [GOC:mah]
synonym: "tachykinin receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb]
is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
is_a: GO:0007217 ! tachykinin receptor signaling pathway

[Term]
id: GO:0007210
name: serotonin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "serotonin receptor signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0007211
name: octopamine/tyramine signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an octopamine/tyramine receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "octopamine/tyramine signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0007212
name: dopamine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "dopamine receptor signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0007213
name: muscarinic acetylcholine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to one of its physiological ligands; muscarinic acetylcholine receptors activate inhibitory G proteins and can be activated by the fungal alkaloid muscarine." [GOC:mah, ISBN:0815316194]
synonym: "acetylcholine receptor signalling, muscarinic pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0007214
name: gamma-aminobutyric acid signaling pathway
namespace: biological_process
def: "The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor." [GOC:mah]
synonym: "4-aminobutanoate signaling pathway" EXACT []
synonym: "4-aminobutanoate signalling pathway" EXACT []
synonym: "4-aminobutyrate signaling pathway" EXACT []
synonym: "4-aminobutyrate signalling pathway" EXACT []
synonym: "GABA signaling pathway" EXACT []
synonym: "GABA signalling pathway" EXACT []
synonym: "gamma-aminobutyric acid signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0007215
name: glutamate signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor." [GOC:mah, PMID:9131252]
synonym: "glutamate signalling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor linked signaling pathway
is_a: GO:0023034 ! intracellular signaling pathway

[Term]
id: GO:0007216
name: metabotropic glutamate receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor coupled to effectors through GTP-binding proteins." [GOC:mah, PMID:9131252]
synonym: "metabotropic glutamate receptor signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway
is_a: GO:0007215 ! glutamate signaling pathway

[Term]
id: GO:0007217
name: tachykinin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor." [GOC:mah, PMID:14723970]
synonym: "tachykinin signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0007218
name: neuropeptide signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194]
synonym: "neuropeptide signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0007219
name: Notch signaling pathway
namespace: biological_process
alt_id: GO:0030179
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell." [GOC:go_curators]
synonym: "N signaling pathway" EXACT []
synonym: "N signalling pathway" EXACT []
synonym: "Notch receptor signaling pathway" EXACT []
synonym: "Notch receptor signalling pathway" EXACT []
synonym: "Notch signalling pathway" EXACT []
synonym: "Notch-receptor signaling pathway" EXACT []
synonym: "Notch-receptor signalling pathway" EXACT []
xref: Reactome:157118 "Signaling by Notch"
xref: Reactome:449207 "Signaling by Notch"
xref: Reactome:470328 "Signaling by Notch"
xref: Reactome:488005 "Signaling by Notch"
xref: Reactome:507968 "Signaling by Notch"
xref: Reactome:517840 "Signaling by Notch"
xref: Reactome:526676 "Signaling by Notch"
xref: Reactome:558111 "Signaling by Notch"
xref: Reactome:592843 "Signaling by Notch"
xref: Reactome:595560 "Signaling by Notch"
xref: Wikipedia:Notch_signaling_pathway
is_a: GO:0007166 ! cell surface receptor linked signaling pathway
is_a: GO:0023034 ! intracellular signaling pathway

[Term]
id: GO:0007220
name: Notch receptor processing
namespace: biological_process
def: "The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688]
synonym: "N receptor processing" EXACT []
xref: Reactome:156988 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor"
xref: Reactome:157212 "A third proteolytic cleavage releases NICD"
xref: Reactome:449206 "A third proteolytic cleavage releases NICD"
xref: Reactome:449214 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor"
xref: Reactome:470327 "A third proteolytic cleavage releases NICD"
xref: Reactome:470335 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor"
xref: Reactome:488004 "A third proteolytic cleavage releases NICD"
xref: Reactome:488012 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor"
xref: Reactome:507967 "A third proteolytic cleavage releases NICD"
xref: Reactome:507976 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor"
xref: Reactome:517839 "A third proteolytic cleavage releases NICD"
xref: Reactome:517846 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor"
xref: Reactome:526675 "A third proteolytic cleavage releases NICD"
xref: Reactome:592842 "A third proteolytic cleavage releases NICD"
is_a: GO:0051605 ! protein maturation by peptide bond cleavage
relationship: part_of GO:0007219 ! Notch signaling pathway

[Term]
id: GO:0007221
name: positive regulation of transcription of Notch receptor target
namespace: biological_process
def: "The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain." [PMID:12651094]
synonym: "N receptor target transcription factor activation" RELATED []
synonym: "Notch receptor target transcription factor activation" RELATED []
is_a: GO:0010552 ! positive regulation of gene-specific transcription from RNA polymerase II promoter
relationship: part_of GO:0007219 ! Notch signaling pathway

[Term]
id: GO:0007223
name: Wnt receptor signaling pathway, calcium modulating pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:bf, GOC:dph, GOC:go_curators, PMID:11532397]
synonym: "frizzled-2 signaling pathway" NARROW []
synonym: "frizzled-2 signalling pathway" NARROW []
synonym: "non-canonical Wnt signaling pathway" RELATED []
is_a: GO:0016055 ! Wnt receptor signaling pathway

[Term]
id: GO:0007224
name: smoothened signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520]
synonym: "hedgehog signaling pathway" EXACT []
synonym: "hh signaling pathway" EXACT []
synonym: "hh signalling pathway" EXACT []
synonym: "smoothened signalling pathway" EXACT []
xref: Wikipedia:Hedgehog_signaling_pathway
is_a: GO:0007166 ! cell surface receptor linked signaling pathway
is_a: GO:0023034 ! intracellular signaling pathway

[Term]
id: GO:0007225
name: patched ligand maturation
namespace: biological_process
def: "The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties." [PMID:15057936]
synonym: "Hedgehog protein processing" NARROW []
synonym: "patched ligand processing" RELATED []
is_a: GO:0051604 ! protein maturation
relationship: part_of GO:0007224 ! smoothened signaling pathway

[Term]
id: GO:0007227
name: signal transduction downstream of smoothened
namespace: biological_process
def: "The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway." [PMID:15057936]
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0007224 ! smoothened signaling pathway

[Term]
id: GO:0007228
name: positive regulation of hh target transcription factor activity
namespace: biological_process
def: "Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited." [GOC:dph, GOC:tb, PMID:11912487, PMID:15057936]
synonym: "activation of hh target transcription factor" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051091 ! positive regulation of transcription factor activity
relationship: part_of GO:0007227 ! signal transduction downstream of smoothened

[Term]
id: GO:0007229
name: integrin-mediated signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands." [GOC:mah]
synonym: "integrin-mediated signalling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor linked signaling pathway
is_a: GO:0023034 ! intracellular signaling pathway

[Term]
id: GO:0007230
name: calcium-o-sensing receptor pathway
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it does not make sense.
is_obsolete: true
consider: GO:0019722

[Term]
id: GO:0007231
name: osmosensory signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated in response to osmotic change." [GOC:jl]
subset: gosubset_prok
synonym: "osmolarity sensing" EXACT []
synonym: "osmolarity sensing signaling pathway" EXACT []
synonym: "osmolarity sensing signalling pathway" EXACT []
synonym: "osmosensory signalling pathway" EXACT []
synonym: "signal transduction during osmotic stress" EXACT []
is_a: GO:0007166 ! cell surface receptor linked signaling pathway
is_a: GO:0023034 ! intracellular signaling pathway
is_a: GO:0071470 ! cellular response to osmotic stress

[Term]
id: GO:0007232
name: osmosensory signaling pathway via Sho1 osmosensor
namespace: biological_process
def: "A series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system." [GOC:jl]
synonym: "osmosensory signalling pathway via Sho1 osmosensor" EXACT []
synonym: "signal transduction during osmotic stress via Sho1 osmosensor" EXACT []
is_a: GO:0007231 ! osmosensory signaling pathway

[Term]
id: GO:0007234
name: osmosensory signaling pathway via two-component system
namespace: biological_process
def: "A series of molecular signals generated in response to osmotic change, as mediated through a two-component (phosphorelay) system." [PMID:9843501]
subset: gosubset_prok
synonym: "osmolarity sensing via two-component system" EXACT []
synonym: "osmolarity signaling pathway via two-component system" EXACT []
synonym: "osmolarity signalling pathway via two-component system" EXACT []
synonym: "osmosensory signalling pathway via two-component system" EXACT []
synonym: "signal transduction during osmotic stress via two-component system" EXACT []
is_a: GO:0000160 ! two-component signal transduction system (phosphorelay)
is_a: GO:0007231 ! osmosensory signaling pathway

[Term]
id: GO:0007235
name: activation of Ypd1 protein
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
is_obsolete: true

[Term]
id: GO:0007236
name: activation of Ssk1 protein
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
is_obsolete: true

[Term]
id: GO:0007237
name: activation of Ssk2/Ssk22 proteins
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
is_obsolete: true

[Term]
id: GO:0007238
name: activation of Pbs2
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
is_obsolete: true

[Term]
id: GO:0007239
name: activation of Hog1
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
is_obsolete: true

[Term]
id: GO:0007240
name: nuclear translocation of Hog1
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
is_obsolete: true

[Term]
id: GO:0007241
name: inactivation of Hog1
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains gene product and species specific information.
is_obsolete: true

[Term]
id: GO:0007242
name: intracellular signaling cascade
namespace: biological_process
def: "A series of reactions within the cell that occur as a result of a single trigger reaction or compound." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "intracellular signalling cascade" EXACT []
xref: Reactome:170968 "Frs2-mediated activation"
xref: Reactome:170984 "ARMS-mediated activation"
xref: Reactome:171007 "p38MAPK events"
xref: Reactome:177504 "Retrograde neurotrophin signalling"
xref: Reactome:187037 "TRKA signalling from the plasma membrane"
xref: Reactome:448461 "ARMS-mediated activation"
xref: Reactome:448464 "TRKA signalling from the plasma membrane"
xref: Reactome:448470 "Frs2-mediated activation"
xref: Reactome:448728 "p38MAPK events"
xref: Reactome:448890 "Retrograde neurotrophin signalling"
xref: Reactome:469591 "ARMS-mediated activation"
xref: Reactome:469594 "TRKA signalling from the plasma membrane"
xref: Reactome:469600 "Frs2-mediated activation"
xref: Reactome:469850 "p38MAPK events"
xref: Reactome:470007 "Retrograde neurotrophin signalling"
xref: Reactome:487310 "ARMS-mediated activation"
xref: Reactome:487313 "TRKA signalling from the plasma membrane"
xref: Reactome:487319 "Frs2-mediated activation"
xref: Reactome:487544 "p38MAPK events"
xref: Reactome:487712 "Retrograde neurotrophin signalling"
xref: Reactome:507261 "ARMS-mediated activation"
xref: Reactome:507264 "TRKA signalling from the plasma membrane"
xref: Reactome:507270 "Frs2-mediated activation"
xref: Reactome:507501 "p38MAPK events"
xref: Reactome:507664 "Retrograde neurotrophin signalling"
xref: Reactome:517287 "Frs2-mediated activation"
xref: Reactome:517290 "TRKA signalling from the plasma membrane"
xref: Reactome:517439 "ARMS-mediated activation"
xref: Reactome:517487 "p38MAPK events"
xref: Reactome:526165 "Frs2-mediated activation"
xref: Reactome:526168 "TRKA signalling from the plasma membrane"
xref: Reactome:526313 "ARMS-mediated activation"
xref: Reactome:526356 "p38MAPK events"
xref: Reactome:531216 "TRKA signalling from the plasma membrane"
xref: Reactome:531361 "Frs2-mediated activation"
xref: Reactome:531363 "ARMS-mediated activation"
xref: Reactome:536586 "TRKA signalling from the plasma membrane"
xref: Reactome:536737 "Frs2-mediated activation"
xref: Reactome:536739 "ARMS-mediated activation"
xref: Reactome:542312 "TRKA signalling from the plasma membrane"
xref: Reactome:542486 "Frs2-mediated activation"
xref: Reactome:542488 "ARMS-mediated activation"
xref: Reactome:547652 "TRKA signalling from the plasma membrane"
xref: Reactome:547813 "Frs2-mediated activation"
xref: Reactome:547815 "ARMS-mediated activation"
xref: Reactome:552323 "TRKA signalling from the plasma membrane"
xref: Reactome:552381 "Frs2-mediated activation"
xref: Reactome:552383 "ARMS-mediated activation"
xref: Reactome:557822 "TRKA signalling from the plasma membrane"
xref: Reactome:557986 "Frs2-mediated activation"
xref: Reactome:557988 "ARMS-mediated activation"
xref: Reactome:568454 "TRKA signalling from the plasma membrane"
xref: Reactome:568637 "Frs2-mediated activation"
xref: Reactome:568639 "ARMS-mediated activation"
xref: Reactome:581652 "TRKA signalling from the plasma membrane"
xref: Reactome:581841 "Frs2-mediated activation"
xref: Reactome:581843 "ARMS-mediated activation"
xref: Reactome:585818 "TRKA signalling from the plasma membrane"
xref: Reactome:592564 "TRKA signalling from the plasma membrane"
xref: Reactome:592747 "Frs2-mediated activation"
xref: Reactome:592749 "ARMS-mediated activation"
xref: Reactome:595384 "TRKA signalling from the plasma membrane"
xref: Reactome:595482 "Frs2-mediated activation"
xref: Reactome:595484 "ARMS-mediated activation"
is_a: GO:0007165 ! signal transduction

[Term]
id: GO:0007243
name: protein kinase cascade
namespace: biological_process
def: "A series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound." [GOC:jl, http://cancerweb.ncl.ac.uk/]
xref: Reactome:163358 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:449005 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:470117 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:487819 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:507780 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:517700 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:526534 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:531331 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:536713 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:542445 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:547790 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:552354 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:557962 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:568601 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:581805 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:585904 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:592718 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:595573 "PKA-mediated phosphorylation of key metabolic factors"
xref: Reactome:599737 "PKA-mediated phosphorylation of key metabolic factors"
is_a: GO:0007242 ! intracellular signaling cascade

[Term]
id: GO:0007244
name: MAPKKK cascade (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. MAPKKK cascade involved in transduction of mating pheromone signal, as described in Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0007245
name: activation of MAPKKK (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAPKKK activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0007246
name: activation of MAPKK (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0007247
name: activation of MAPK (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Upregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true
consider: GO:0000750

[Term]
id: GO:0007248
name: nuclear translocation of MAPK (mating sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0007249
name: I-kappaB kinase/NF-kappaB cascade
namespace: biological_process
def: "A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase." [GOC:jl, PMID:12773372]
synonym: "activation of the inhibitor of kappa kinase" RELATED []
synonym: "NIK-I-kappaB/NF-kappaB cascade" EXACT []
xref: Reactome:166058 "MyD88 cascade"
xref: Reactome:166166 "TRAM Cascade"
xref: Reactome:449163 "MyD88 cascade"
xref: Reactome:470275 "MyD88 cascade"
xref: Reactome:507925 "MyD88 cascade"
is_a: GO:0007243 ! protein kinase cascade

[Term]
id: GO:0007250
name: activation of NF-kappaB-inducing kinase activity
namespace: biological_process
def: "The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues." [GOC:jl, PMID:12773372]
synonym: "positive regulation of NF-kappaB-inducing kinase activity" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0032147 ! activation of protein kinase activity
relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB cascade

[Term]
id: GO:0007251
name: activation of the inhibitor of kappa kinase
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because its meaning was unclear.
is_obsolete: true
consider: GO:0007249

[Term]
id: GO:0007252
name: I-kappaB phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into an I-kappaB protein." [GOC:jl]
is_a: GO:0006468 ! protein amino acid phosphorylation
relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB cascade

[Term]
id: GO:0007253
name: cytoplasmic sequestering of NF-kappaB
namespace: biological_process
def: "The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl]
synonym: "cytoplasmic NF-kappaB retention" EXACT []
synonym: "cytoplasmic NF-kappaB sequestration" EXACT []
synonym: "cytoplasmic NF-kappaB storage" EXACT []
synonym: "cytoplasmic retention of NF-kappaB" EXACT []
synonym: "cytoplasmic sequestration of NF-kappaB" EXACT []
synonym: "cytoplasmic storage of NF-kappaB" EXACT []
synonym: "maintenance of NF-kappaB location in cytoplasm" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042347 ! negative regulation of NF-kappaB import into nucleus
is_a: GO:0042994 ! cytoplasmic sequestering of transcription factor
relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB cascade

[Term]
id: GO:0007254
name: JNK cascade
namespace: biological_process
def: "A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress." [GOC:bf, PMID:11790549]
synonym: "JNK1 cascade" NARROW [GOC:add]
synonym: "JNK2 cascade" NARROW [GOC:add]
synonym: "JNK3 cascade" NARROW [GOC:add]
synonym: "MAPK10 cascade" NARROW [GOC:add]
synonym: "MAPK8 cascade" NARROW [GOC:add]
synonym: "MAPK9 cascade" NARROW [GOC:add]
synonym: "SAPK cascade" BROAD []
synonym: "stress-activated protein kinase cascade" BROAD []
is_a: GO:0000165 ! MAPKKK cascade
is_a: GO:0031098 ! stress-activated protein kinase signaling pathway

[Term]
id: GO:0007256
name: activation of JNKK activity
namespace: biological_process
def: "The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity in response to phosphorylation by a member of the JUN kinase kinase kinase (JNKKK) family, or another upstream kinase. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress." [GOC:bf, PMID:11790549]
synonym: "activation of JUN kinase kinase activity" EXACT []
synonym: "positive regulation of JUNKK activity" BROAD []
is_a: GO:0000186 ! activation of MAPKK activity
relationship: part_of GO:0007254 ! JNK cascade

[Term]
id: GO:0007257
name: activation of JUN kinase activity
namespace: biological_process
def: "The initiation of the activity of the inactive enzyme JUN kinase by phosphorylation by a JUN kinase kinase (JNKK)." [GOC:bf]
synonym: "activation of SAPK activity" BROAD []
is_a: GO:0000187 ! activation of MAPK activity
is_a: GO:0043507 ! positive regulation of JUN kinase activity
relationship: part_of GO:0007254 ! JNK cascade

[Term]
id: GO:0007258
name: JUN phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into a JUN protein." [GOC:jl]
is_a: GO:0006468 ! protein amino acid phosphorylation
relationship: part_of GO:0007254 ! JNK cascade

[Term]
id: GO:0007259
name: JAK-STAT cascade
namespace: biological_process
def: "Any process by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes." [GOC:jl, PMID:12039028]
is_a: GO:0007243 ! protein kinase cascade

[Term]
id: GO:0007260
name: tyrosine phosphorylation of STAT protein
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594]
is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation
relationship: part_of GO:0007259 ! JAK-STAT cascade

[Term]
id: GO:0007261
name: JAK-induced STAT protein dimerization
namespace: biological_process
def: "The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GOC:jl, PMID:12039028]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0007259 ! JAK-STAT cascade

[Term]
id: GO:0007262
name: STAT protein nuclear translocation
namespace: biological_process
def: "The transport of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GOC:jl, PMID:12039028]
is_a: GO:0000060 ! protein import into nucleus, translocation
relationship: part_of GO:0007259 ! JAK-STAT cascade

[Term]
id: GO:0007263
name: nitric oxide mediated signal transduction
namespace: biological_process
def: "A series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:jl]
synonym: "nitric oxide-mediated signal transduction" EXACT []
synonym: "NO mediated signal transduction" EXACT []
synonym: "NO-mediated signal transduction" EXACT []
is_a: GO:0007242 ! intracellular signaling cascade

[Term]
id: GO:0007264
name: small GTPase mediated signal transduction
namespace: biological_process
def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah]
subset: gosubset_prok
synonym: "small GTPase-mediated signal transduction" EXACT []
xref: Reactome:187706 "Signalling to p38 via RIT and RIN"
xref: Reactome:194315 "Signaling by Rho GTPases"
xref: Reactome:448659 "Signalling to p38 via RIT and RIN"
xref: Reactome:449054 "Signaling by Rho GTPases"
xref: Reactome:469787 "Signalling to p38 via RIT and RIN"
xref: Reactome:470168 "Signaling by Rho GTPases"
xref: Reactome:487481 "Signalling to p38 via RIT and RIN"
xref: Reactome:487858 "Signaling by Rho GTPases"
xref: Reactome:507441 "Signalling to p38 via RIT and RIN"
xref: Reactome:507829 "Signaling by Rho GTPases"
xref: Reactome:517445 "Signalling to p38 via RIT and RIN"
xref: Reactome:517735 "Signaling by Rho GTPases"
xref: Reactome:526319 "Signalling to p38 via RIT and RIN"
xref: Reactome:526573 "Signaling by Rho GTPases"
xref: Reactome:531369 "Signalling to p38 via RIT and RIN"
xref: Reactome:531376 "Signaling by Rho GTPases"
xref: Reactome:536745 "Signalling to p38 via RIT and RIN"
xref: Reactome:536751 "Signaling by Rho GTPases"
xref: Reactome:542494 "Signalling to p38 via RIT and RIN"
xref: Reactome:542501 "Signaling by Rho GTPases"
xref: Reactome:547821 "Signalling to p38 via RIT and RIN"
xref: Reactome:547828 "Signaling by Rho GTPases"
xref: Reactome:552389 "Signalling to p38 via RIT and RIN"
xref: Reactome:552396 "Signaling by Rho GTPases"
xref: Reactome:557994 "Signalling to p38 via RIT and RIN"
xref: Reactome:558004 "Signaling by Rho GTPases"
xref: Reactome:568645 "Signalling to p38 via RIT and RIN"
xref: Reactome:568653 "Signaling by Rho GTPases"
xref: Reactome:581849 "Signalling to p38 via RIT and RIN"
xref: Reactome:581857 "Signaling by Rho GTPases"
xref: Reactome:585923 "Signaling by Rho GTPases"
xref: Reactome:592755 "Signalling to p38 via RIT and RIN"
xref: Reactome:592763 "Signaling by Rho GTPases"
xref: Reactome:595490 "Signalling to p38 via RIT and RIN"
is_a: GO:0007242 ! intracellular signaling cascade

[Term]
id: GO:0007265
name: Ras protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf]
synonym: "Ras mediated signal transduction" EXACT []
xref: Reactome:167044 "Signalling to RAS"
xref: Reactome:448653 "Signalling to RAS"
xref: Reactome:469781 "Signalling to RAS"
xref: Reactome:487475 "Signalling to RAS"
xref: Reactome:507435 "Signalling to RAS"
xref: Reactome:517438 "Signalling to RAS"
xref: Reactome:526312 "Signalling to RAS"
xref: Reactome:531359 "Signalling to RAS"
xref: Reactome:536735 "Signalling to RAS"
xref: Reactome:542484 "Signalling to RAS"
xref: Reactome:547811 "Signalling to RAS"
xref: Reactome:552379 "Signalling to RAS"
xref: Reactome:557984 "Signalling to RAS"
xref: Reactome:568635 "Signalling to RAS"
xref: Reactome:581839 "Signalling to RAS"
xref: Reactome:592745 "Signalling to RAS"
xref: Reactome:595480 "Signalling to RAS"
is_a: GO:0007264 ! small GTPase mediated signal transduction

[Term]
id: GO:0007266
name: Rho protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf]
synonym: "Rho mediated signal transduction" EXACT []
is_a: GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0007267
name: cell-cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another." [GOC:mah]
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
synonym: "cell-cell signalling" EXACT []
is_a: GO:0007154 ! cell communication
is_a: GO:0023060 ! signal transmission

[Term]
id: GO:0007268
name: synaptic transmission
namespace: biological_process
def: "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435]
synonym: "neurotransmission" RELATED [GOC:dph]
synonym: "regulation of synapse" RELATED []
synonym: "signal transmission across a synapse" EXACT []
xref: Reactome:112315 "Transmission across Chemical Synapses"
xref: Reactome:112316 "Synaptic Transmission"
xref: Reactome:448603 "Transmission across Chemical Synapses"
xref: Reactome:448604 "Synaptic Transmission"
xref: Reactome:469732 "Transmission across Chemical Synapses"
xref: Reactome:469733 "Synaptic Transmission"
xref: Reactome:487443 "Transmission across Chemical Synapses"
xref: Reactome:487444 "Synaptic Transmission"
xref: Reactome:507400 "Transmission across Chemical Synapses"
xref: Reactome:507401 "Synaptic Transmission"
xref: Reactome:517402 "Transmission across Chemical Synapses"
xref: Reactome:517403 "Synaptic Transmission"
xref: Reactome:526277 "Transmission across Chemical Synapses"
xref: Reactome:526278 "Synaptic Transmission"
xref: Reactome:531145 "Transmission across Chemical Synapses"
xref: Reactome:531146 "Synaptic Transmission"
xref: Reactome:536516 "Transmission across Chemical Synapses"
xref: Reactome:536517 "Synaptic Transmission"
xref: Reactome:542234 "Transmission across Chemical Synapses"
xref: Reactome:542235 "Synaptic Transmission"
xref: Reactome:547584 "Transmission across Chemical Synapses"
xref: Reactome:547585 "Synaptic Transmission"
xref: Reactome:552193 "Transmission across Chemical Synapses"
xref: Reactome:552194 "Synaptic Transmission"
xref: Reactome:557778 "Transmission across Chemical Synapses"
xref: Reactome:557779 "Synaptic Transmission"
xref: Reactome:568391 "Transmission across Chemical Synapses"
xref: Reactome:568392 "Synaptic Transmission"
xref: Reactome:581593 "Transmission across Chemical Synapses"
xref: Reactome:581594 "Synaptic Transmission"
xref: Reactome:585944 "Transmission across Chemical Synapses"
xref: Reactome:585945 "Synaptic Transmission"
xref: Reactome:592489 "Transmission across Chemical Synapses"
xref: Reactome:592490 "Synaptic Transmission"
xref: Reactome:597312 "Transmission across Chemical Synapses"
xref: Reactome:597313 "Synaptic Transmission"
xref: Reactome:598113 "Transmission across Chemical Synapses"
xref: Reactome:598114 "Synaptic Transmission"
xref: Reactome:599660 "Transmission across Chemical Synapses"
xref: Reactome:599661 "Synaptic Transmission"
xref: Reactome:600676 "Transmission across Chemical Synapses"
xref: Reactome:600677 "Synaptic Transmission"
xref: Reactome:602473 "Transmission across Chemical Synapses"
xref: Reactome:602474 "Synaptic Transmission"
xref: Wikipedia:Neurotransmission
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0007269
name: neurotransmitter secretion
namespace: biological_process
def: "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GOC:dph, http://cancerweb.ncl.ac.uk]
synonym: "neurotransmitter release" EXACT []
xref: Reactome:112310 "Neurotransmitter Release Cycle"
xref: Reactome:168799 "Botulinum neurotoxicity"
xref: Reactome:449020 "Neurotransmitter Release Cycle"
xref: Reactome:470132 "Neurotransmitter Release Cycle"
xref: Reactome:487836 "Neurotransmitter Release Cycle"
xref: Reactome:507794 "Neurotransmitter Release Cycle"
xref: Reactome:517712 "Neurotransmitter Release Cycle"
xref: Reactome:526553 "Neurotransmitter Release Cycle"
xref: Reactome:531345 "Neurotransmitter Release Cycle"
xref: Reactome:536814 "Neurotransmitter Release Cycle"
xref: Reactome:542459 "Neurotransmitter Release Cycle"
xref: Reactome:547893 "Neurotransmitter Release Cycle"
xref: Reactome:552471 "Neurotransmitter Release Cycle"
xref: Reactome:558079 "Neurotransmitter Release Cycle"
xref: Reactome:568615 "Neurotransmitter Release Cycle"
xref: Reactome:581819 "Neurotransmitter Release Cycle"
xref: Reactome:585965 "Neurotransmitter Release Cycle"
xref: Reactome:592822 "Neurotransmitter Release Cycle"
xref: Reactome:597436 "Neurotransmitter Release Cycle"
xref: Reactome:598201 "Neurotransmitter Release Cycle"
xref: Reactome:599767 "Neurotransmitter Release Cycle"
xref: Reactome:600675 "Neurotransmitter Release Cycle"
xref: Reactome:602582 "Neurotransmitter Release Cycle"
is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0003001 ! generation of a signal involved in cell-cell signaling
is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0007270
name: nerve-nerve synaptic transmission
namespace: biological_process
def: "The process of communication from a neuron to another neuron across a synapse." [GOC:jl, MeSH:D009435]
is_a: GO:0007268 ! synaptic transmission

[Term]
id: GO:0007271
name: synaptic transmission, cholinergic
namespace: biological_process
def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:kmv]
is_a: GO:0007268 ! synaptic transmission

[Term]
id: GO:0007272
name: ensheathment of neurons
namespace: biological_process
def: "The process whereby glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment." [GOC:dgh, GOC:dph, GOC:tb]
synonym: "ionic insulation of neurons by glial cells" RELATED []
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0007399 ! nervous system development
relationship: part_of GO:0019228 ! regulation of action potential in neuron

[Term]
id: GO:0007273
name: regulation of synapse
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the term string made no sense.
is_obsolete: true
consider: GO:0007268

[Term]
id: GO:0007274
name: neuromuscular synaptic transmission
namespace: biological_process
def: "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435]
is_a: GO:0007268 ! synaptic transmission

[Term]
id: GO:0007275
name: multicellular organismal development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb]
comment: Note that this term was 'developmental process'.
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0007276
name: gamete generation
namespace: biological_process
alt_id: GO:0009552
def: "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu]
synonym: "gametogenesis" RELATED []
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0019953 ! sexual reproduction

[Term]
id: GO:0007277
name: pole cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure." [GOC:jic]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048468 ! cell development
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007276 ! gamete generation

[Term]
id: GO:0007278
name: pole cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
is_a: GO:0001709 ! cell fate determination
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007277 ! pole cell development

[Term]
id: GO:0007279
name: pole cell formation
namespace: biological_process
def: "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212]
comment: See also the Cell Ontology term 'pole cell ; CL:0000301'.
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0007349 ! cellularization
relationship: part_of GO:0007277 ! pole cell development

[Term]
id: GO:0007280
name: pole cell migration
namespace: biological_process
def: "The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212]
comment: See also the Cell Ontology term 'pole cell ; CL:0000301'.
is_a: GO:0008354 ! germ cell migration

[Term]
id: GO:0007281
name: germ cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators]
synonym: "germ-cell development" EXACT []
synonym: "primordial germ cell development" NARROW []
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048468 ! cell development
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007276 ! gamete generation

[Term]
id: GO:0007282
name: cystoblast division
namespace: biological_process
def: "The four rounds of incomplete mitosis undergone by the cystoblast to form a 16-cell cyst. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this is found in Drosophila melanogaster." [PMID:11131529]
synonym: "cystoblast cell division" EXACT []
is_a: GO:0008356 ! asymmetric cell division
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007281 ! germ cell development

[Term]
id: GO:0007283
name: spermatogenesis
namespace: biological_process
def: "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jic, http://cancerweb.ncl.ac.uk]
synonym: "generation of spermatozoa" EXACT systematic_synonym []
xref: Wikipedia:Spermatogenesis
is_a: GO:0048232 ! male gamete generation

[Term]
id: GO:0007284
name: spermatogonial cell division
namespace: biological_process
def: "The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form a cyst of secondary spermatogonia (primary spermatocytes)." [GOC:bf, ISBN:0879694238]
comment: See also the Cell Ontology terms 'spermatogonium ; CL:0000020' and 'primary spermatocyte ; CL:0000656'.
is_a: GO:0048610 ! reproductive cellular process
is_a: GO:0051301 ! cell division
relationship: part_of GO:0048136 ! male germ-line cyst formation

[Term]
id: GO:0007285
name: primary spermatocyte growth
namespace: biological_process
def: "The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis." [GOC:jic, ISBN:0879694238]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048588 ! developmental cell growth
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0007286
name: spermatid development
namespace: biological_process
def: "The process whose specific outcome is the progression of a male gamete over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:go_curators]
synonym: "spermatid cell development" EXACT []
synonym: "spermiogenesis" EXACT []
xref: Wikipedia:Spermiogenesis
is_a: GO:0007281 ! germ cell development
relationship: part_of GO:0048515 ! spermatid differentiation

[Term]
id: GO:0007287
name: Nebenkern assembly
namespace: biological_process
def: "Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern." [GOC:bf, ISBN:0879694238]
comment: See also the cellular component term 'Nebenkern ; GO:0016006', and the fly_anatomy.ontology term 'Nebenkern ; FBbt:00004943'.
synonym: "Nebenkern formation" RELATED [GOC:dph]
is_a: GO:0008053 ! mitochondrial fusion
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0007288
name: sperm axoneme assembly
namespace: biological_process
def: "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, ISBN:0198547684]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0035084 ! flagellar axoneme assembly
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0007289
name: spermatid nucleus differentiation
namespace: biological_process
def: "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah]
comment: See also the Cell Ontology term 'spermatid ; CL:0000018'.
synonym: "spermatid nuclear differentiation" EXACT []
is_a: GO:0006997 ! nucleus organization
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0007290
name: spermatid nucleus elongation
namespace: biological_process
def: "The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation." [GOC:bf, GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]
synonym: "spermatid nuclear elongation" EXACT []
is_a: GO:0006997 ! nucleus organization
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0007291
name: sperm individualization
namespace: biological_process
def: "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0007349 ! cellularization
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0007292
name: female gamete generation
namespace: biological_process
def: "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0007276 ! gamete generation

[Term]
id: GO:0007293
name: germarium-derived egg chamber formation
namespace: biological_process
def: "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0007294
name: germarium-derived oocyte fate determination
namespace: biological_process
alt_id: GO:0016350
def: "Process by which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "maintenance of oocyte identity" RELATED []
synonym: "oocyte cell fate determination" RELATED []
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0030716 ! oocyte fate determination
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0030706 ! germarium-derived oocyte differentiation

[Term]
id: GO:0007295
name: growth of a germarium-derived egg chamber
namespace: biological_process
def: "Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "egg chamber growth" EXACT []
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0007296
name: vitellogenesis
namespace: biological_process
def: "The production of yolk. Yolk is a mixture of materials used for embryonic nutrition." [GOC:dph, ISBN:0879694238]
synonym: "yolk production" EXACT systematic_synonym []
xref: Wikipedia:Vitellogenesis
is_a: GO:0007028 ! cytoplasm organization
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007292 ! female gamete generation

[Term]
id: GO:0007297
name: ovarian follicle cell migration
namespace: biological_process
def: "The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
synonym: "follicle cell migration" BROAD []
is_a: GO:0016477 ! cell migration
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0030707 ! ovarian follicle cell development

[Term]
id: GO:0007298
name: border follicle cell migration
namespace: biological_process
def: "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
synonym: "border cell migration" BROAD []
is_a: GO:0007297 ! ovarian follicle cell migration

[Term]
id: GO:0007299
name: ovarian follicle cell adhesion
namespace: biological_process
def: "The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12642496]
synonym: "follicle cell adhesion" BROAD []
is_a: GO:0016337 ! cell-cell adhesion
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0030707 ! ovarian follicle cell development

[Term]
id: GO:0007300
name: ovarian nurse cell to oocyte transport
namespace: biological_process
def: "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "nurse cell to oocyte transport" BROAD []
is_a: GO:0006810 ! transport
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0007301
name: female germline ring canal formation
namespace: biological_process
def: "Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238]
synonym: "nurse cell ring canal formation" NARROW []
synonym: "ovarian ring canal formation" NARROW []
is_a: GO:0030725 ! germline ring canal formation
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation
relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport

[Term]
id: GO:0007302
name: nurse cell nucleus anchoring
namespace: biological_process
def: "Attachment of the nurse cell nucleus to the plasma membrane." [ISBN:0879694238]
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport

[Term]
id: GO:0007303
name: cytoplasmic transport, nurse cell to oocyte
namespace: biological_process
def: "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238]
is_a: GO:0016482 ! cytoplasmic transport
relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport

[Term]
id: GO:0007304
name: chorion-containing eggshell formation
namespace: biological_process
def: "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
synonym: "eggshell formation" BROAD []
is_a: GO:0030703 ! eggshell formation
relationship: part_of GO:0030707 ! ovarian follicle cell development

[Term]
id: GO:0007305
name: vitelline membrane formation in chorion-containing eggshell
namespace: biological_process
def: "Construction of the vitelline membrane portion of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0030704 ! vitelline membrane formation
relationship: part_of GO:0007304 ! chorion-containing eggshell formation

[Term]
id: GO:0007306
name: eggshell chorion assembly
namespace: biological_process
def: "Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
synonym: "eggshell chorion formation" EXACT [GOC:dph, GOC:tb]
synonym: "insect chorion formation" RELATED []
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
relationship: part_of GO:0007304 ! chorion-containing eggshell formation

[Term]
id: GO:0007307
name: eggshell chorion gene amplification
namespace: biological_process
def: "Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771]
is_a: GO:0006277 ! DNA amplification
relationship: part_of GO:0007306 ! eggshell chorion assembly

[Term]
id: GO:0007308
name: oocyte construction
namespace: biological_process
alt_id: GO:0048110
def: "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "oocyte arrangement" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048469 ! cell maturation
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0048599 ! oocyte development

[Term]
id: GO:0007309
name: oocyte axis specification
namespace: biological_process
alt_id: GO:0048111
def: "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "oocyte axis determination" RELATED []
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0007308 ! oocyte construction

[Term]
id: GO:0007310
name: oocyte dorsal/ventral axis specification
namespace: biological_process
alt_id: GO:0008072
alt_id: GO:0048123
def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "oocyte dorsal-ventral axis specification" EXACT [GOC:mah]
synonym: "oocyte dorsal/ventral axis determination" RELATED [GOC:dph, GOC:tb]
synonym: "oocyte dorsoventral axis specification" EXACT [GOC:mah]
is_a: GO:0007309 ! oocyte axis specification
is_a: GO:0009950 ! dorsal/ventral axis specification

[Term]
id: GO:0007311
name: maternal specification of dorsal/ventral axis, oocyte, germ-line encoded
namespace: biological_process
alt_id: GO:0048124
def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
synonym: "maternal determination of dorsal/ventral axis, oocyte, germ-line encoded" EXACT [GOC:dph, GOC:tb]
synonym: "maternal specification of dorsal-ventral axis, oocyte, germ-line encoded" EXACT [GOC:mah]
synonym: "maternal specification of dorsoventral axis, oocyte, germ-line encoded" EXACT [GOC:mah]
is_a: GO:0007310 ! oocyte dorsal/ventral axis specification

[Term]
id: GO:0007312
name: oocyte nucleus migration during oocyte axis specification
namespace: biological_process
alt_id: GO:0008102
alt_id: GO:0048128
def: "The directed movement of the oocyte nucleus within the cell during the establishment and maintenance of the axes of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb]
synonym: "oocyte axis determination, oocyte nuclear migration" EXACT []
synonym: "oocyte axis determination, oocyte nucleus migration" EXACT []
synonym: "oocyte nuclear migration during oocyte axis determination" EXACT []
synonym: "oocyte nucleus migration during oocyte axis determination" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007097 ! nuclear migration
is_a: GO:0030722 ! establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification

[Term]
id: GO:0007313
name: maternal specification of dorsal/ventral axis, oocyte, soma encoded
namespace: biological_process
alt_id: GO:0048125
def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
synonym: "maternal determination of dorsal/ventral axis, oocyte, soma encoded" EXACT [GOC:dph, GOC:tb]
synonym: "maternal specification of dorsal-ventral axis, oocyte, soma encoded" EXACT [GOC:mah]
synonym: "maternal specification of dorsoventral axis, oocyte, soma encoded" EXACT [GOC:mah]
is_a: GO:0007310 ! oocyte dorsal/ventral axis specification

[Term]
id: GO:0007314
name: oocyte anterior/posterior axis specification
namespace: biological_process
alt_id: GO:0048112
def: "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238]
synonym: "oocyte anterior/posterior axis determination" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007309 ! oocyte axis specification
is_a: GO:0009948 ! anterior/posterior axis specification
relationship: part_of GO:0008358 ! maternal determination of anterior/posterior axis, embryo

[Term]
id: GO:0007315
name: pole plasm assembly
namespace: biological_process
alt_id: GO:0048113
def: "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu]
is_a: GO:0007028 ! cytoplasm organization
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0007314 ! oocyte anterior/posterior axis specification

[Term]
id: GO:0007316
name: pole plasm RNA localization
namespace: biological_process
alt_id: GO:0048116
def: "Any process by which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
synonym: "establishment and maintenance of pole plasm RNA localization" EXACT []
synonym: "oocyte pole plasm RNA localization" EXACT []
is_a: GO:0006403 ! RNA localization
relationship: part_of GO:0007315 ! pole plasm assembly

[Term]
id: GO:0007317
name: regulation of pole plasm oskar mRNA localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process by which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb]
synonym: "regulation of oocyte pole plasm oskar mRNA localization" EXACT []
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0060281 ! regulation of oocyte development
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0045451 ! pole plasm oskar mRNA localization

[Term]
id: GO:0007318
name: pole plasm protein localization
namespace: biological_process
alt_id: GO:0048115
def: "Any process by which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
synonym: "establishment and maintenance of pole plasm protein localization" EXACT []
synonym: "oocyte pole plasm protein localization" EXACT []
is_a: GO:0008105 ! asymmetric protein localization
relationship: part_of GO:0007315 ! pole plasm assembly

[Term]
id: GO:0007319
name: negative regulation of oskar mRNA translation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems]
synonym: "down regulation of oskar mRNA translation" EXACT []
synonym: "down-regulation of oskar mRNA translation" EXACT []
synonym: "downregulation of oskar mRNA translation" EXACT []
synonym: "inhibition of oskar mRNA translation" NARROW []
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0046011 ! regulation of oskar mRNA translation

[Term]
id: GO:0007320
name: insemination
namespace: biological_process
def: "The introduction of semen or sperm into the genital tract of a female." [ISBN:0582227089]
xref: Wikipedia:Insemination
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0007620 ! copulation

[Term]
id: GO:0007321
name: sperm displacement
namespace: biological_process
def: "The physical displacement of sperm stored from previous mating encounters." [PMID:10440373]
is_a: GO:0046692 ! sperm competition

[Term]
id: GO:0007323
name: peptide pheromone maturation
namespace: biological_process
alt_id: GO:0007324
alt_id: GO:0007326
alt_id: GO:0046613
def: "The generation of a mature, active peptide pheromone via processes unique to its processing and modification. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh]
subset: gosubset_prok
synonym: "pheromone processing" EXACT []
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0007329
name: positive regulation of transcription from RNA polymerase II promoter by pheromones
namespace: biological_process
def: "Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators]
synonym: "activation of transcription from RNA polymerase II promoter by pheromones" NARROW []
synonym: "positive regulation of transcription from Pol II promoter by pheromones" EXACT []
synonym: "stimulation of transcription from RNA polymerase II promoter by pheromones" NARROW []
synonym: "up regulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
synonym: "up-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
synonym: "upregulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
is_a: GO:0009371 ! positive regulation of transcription by pheromones
is_a: GO:0010552 ! positive regulation of gene-specific transcription from RNA polymerase II promoter
is_a: GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones

[Term]
id: GO:0007336
name: bilateral process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it gives no indication of what it refers to.
is_obsolete: true

[Term]
id: GO:0007337
name: unilateral process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it gives no indication of what it refers to.
is_obsolete: true

[Term]
id: GO:0007338
name: single fertilization
namespace: biological_process
def: "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu]
synonym: "zygote biosynthesis" BROAD []
synonym: "zygote formation" BROAD []
is_a: GO:0009566 ! fertilization

[Term]
id: GO:0007339
name: binding of sperm to zona pellucida
namespace: biological_process
def: "The process by which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437]
synonym: "ZPG binding" RELATED []
is_a: GO:0035036 ! sperm-egg recognition

[Term]
id: GO:0007340
name: acrosome reaction
namespace: biological_process
def: "The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg." [GOC:dph, PMID:3886029]
xref: Wikipedia:Acrosome_reaction
is_a: GO:0017156 ! calcium ion-dependent exocytosis
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0007341
name: penetration of zona pellucida
namespace: biological_process
def: "The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html]
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0007342
name: fusion of sperm to egg plasma membrane
namespace: biological_process
def: "The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html]
synonym: "sperm-oocyte fusion" NARROW []
is_a: GO:0045026 ! plasma membrane fusion
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0007343
name: egg activation
namespace: biological_process
def: "The process whereby the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751]
xref: Wikipedia:Egg_activation
is_a: GO:0001775 ! cell activation
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0007344
name: pronuclear fusion
namespace: biological_process
def: "The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X]
is_a: GO:0000741 ! karyogamy
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0007345
name: embryogenesis and morphogenesis
namespace: biological_process
def: "OBSOLETE. Formation and development of an embryo and its organized structures." [GOC:ems, ISBN:0070524300, ISBN:0140512888]
comment: This term was made obsolete because more appropriate terms were created. Morphogenesis in plants also occurs outside of embryogenesis.
is_obsolete: true
consider: GO:0009653
consider: GO:0009790

[Term]
id: GO:0007346
name: regulation of mitotic cell cycle
namespace: biological_process
def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
subset: goslim_pombe
synonym: "control of mitotic cell cycle progression" EXACT []
synonym: "mitotic cell cycle control" EXACT []
synonym: "mitotic cell cycle modulation" EXACT []
synonym: "mitotic cell cycle regulation" EXACT []
synonym: "mitotic cell cycle regulator" RELATED []
synonym: "modulation of mitotic cell cycle progression" EXACT []
synonym: "regulation of mitotic cell cycle progression" EXACT []
synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051726 ! regulation of cell cycle
relationship: regulates GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0007347
name: regulation of preblastoderm mitotic cell cycle
namespace: biological_process
def: "A cell cycle process that modulates the rate or extent of the progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "control of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "modulation of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "preblastoderm mitotic cell cycle control" EXACT []
synonym: "preblastoderm mitotic cell cycle modulation" EXACT []
synonym: "preblastoderm mitotic cell cycle regulation" EXACT []
synonym: "preblastoderm mitotic cell cycle regulator" RELATED []
synonym: "regulation of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic
relationship: regulates GO:0035185 ! preblastoderm mitotic cell cycle

[Term]
id: GO:0007348
name: regulation of syncytial blastoderm mitotic cell cycle
namespace: biological_process
def: "A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "control of syncytial blastoderm cell cycle progression" EXACT []
synonym: "modulation of syncytial blastoderm cell cycle progression" EXACT []
synonym: "regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of syncytial blastoderm cell cycle" EXACT []
synonym: "regulation of syncytial blastoderm cell cycle progression" EXACT []
synonym: "syncytial blastoderm cell cycle control" EXACT []
synonym: "syncytial blastoderm cell cycle modulation" EXACT []
synonym: "syncytial blastoderm cell cycle regulation" EXACT []
synonym: "syncytial blastoderm cell cycle regulator" RELATED []
is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic
is_a: GO:0022402 ! cell cycle process
relationship: regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle

[Term]
id: GO:0007349
name: cellularization
namespace: biological_process
alt_id: GO:0009796
def: "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0007350
name: blastoderm segmentation
namespace: biological_process
def: "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0009880 ! embryonic pattern specification
is_a: GO:0035282 ! segmentation

[Term]
id: GO:0007351
name: tripartite regional subdivision
namespace: biological_process
def: "Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007350 ! blastoderm segmentation

[Term]
id: GO:0007352
name: zygotic specification of dorsal/ventral axis
namespace: biological_process
def: "The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote." [GOC:bf]
synonym: "zygotic determination of dorsal-ventral axis" RELATED [GOC:mah]
synonym: "zygotic determination of dorsal/ventral axis" RELATED [GOC:dph]
synonym: "zygotic determination of dorsoventral axis" RELATED [GOC:mah]
is_a: GO:0000578 ! embryonic axis specification
is_a: GO:0009950 ! dorsal/ventral axis specification

[Term]
id: GO:0007353
name: ventral/lateral system
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not describe a biological process.
is_obsolete: true
consider: GO:0009880

[Term]
id: GO:0007354
name: zygotic determination of anterior/posterior axis, embryo
namespace: biological_process
def: "The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0008595 ! anterior/posterior axis specification, embryo

[Term]
id: GO:0007355
name: anterior region determination
namespace: biological_process
def: "Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0009952 ! anterior/posterior pattern formation
relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo

[Term]
id: GO:0007356
name: thorax and anterior abdomen determination
namespace: biological_process
def: "Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0009952 ! anterior/posterior pattern formation
relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo

[Term]
id: GO:0007357
name: positive regulation of central gap gene transcription
namespace: biological_process
def: "The activation of genes encoding transcription factors in the central region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila Kruppel gene by the hunchback and bicoid gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
synonym: "activation of central gap gene" BROAD []
synonym: "activation of central gap gene transcription" NARROW []
synonym: "stimulation of central gap gene transcription" NARROW []
synonym: "up regulation of central gap gene transcription" EXACT []
synonym: "up-regulation of central gap gene transcription" EXACT []
synonym: "upregulation of central gap gene transcription" EXACT []
is_a: GO:0010552 ! positive regulation of gene-specific transcription from RNA polymerase II promoter
relationship: part_of GO:0007356 ! thorax and anterior abdomen determination

[Term]
id: GO:0007358
name: establishment of central gap gene boundaries
namespace: biological_process
def: "Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0007356 ! thorax and anterior abdomen determination

[Term]
id: GO:0007359
name: posterior abdomen determination
namespace: biological_process
def: "The regionalization process by which the posterior (abdominal) regions of the embryo are specified by the gap genes." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
comment: Note that this process is exemplified in insects by the actions of the knirps gene product.
is_a: GO:0009952 ! anterior/posterior pattern formation
relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo

[Term]
id: GO:0007360
name: positive regulation of posterior gap gene transcription
namespace: biological_process
def: "The activation of genes encoding transcription factors in the posterior region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila knirps gene." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
synonym: "activation of posterior gap gene" BROAD []
synonym: "activation of posterior gap gene transcription" NARROW []
synonym: "knirps activation" NARROW []
synonym: "stimulation of posterior gap gene transcription" NARROW []
synonym: "up regulation of posterior gap gene transcription" EXACT []
synonym: "up-regulation of posterior gap gene transcription" EXACT []
synonym: "upregulation of posterior gap gene transcription" EXACT []
is_a: GO:0010552 ! positive regulation of gene-specific transcription from RNA polymerase II promoter
relationship: part_of GO:0007359 ! posterior abdomen determination

[Term]
id: GO:0007361
name: establishment of posterior gap gene boundaries
namespace: biological_process
def: "Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0007359 ! posterior abdomen determination

[Term]
id: GO:0007362
name: terminal region determination
namespace: biological_process
def: "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0009880 ! embryonic pattern specification
relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo

[Term]
id: GO:0007363
name: positive regulation of terminal gap gene transcription
namespace: biological_process
def: "The activation of genes encoding transcription factors at the anterior and posterior ends of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila tailless and huckebein genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
synonym: "activation of terminal gap gene" BROAD []
synonym: "activation of terminal gap gene transcription" NARROW []
synonym: "stimulation of terminal gap gene transcription" NARROW []
synonym: "up regulation of terminal gap gene transcription" EXACT []
synonym: "up-regulation of terminal gap gene transcription" EXACT []
synonym: "upregulation of terminal gap gene transcription" EXACT []
is_a: GO:0010552 ! positive regulation of gene-specific transcription from RNA polymerase II promoter
relationship: part_of GO:0007362 ! terminal region determination

[Term]
id: GO:0007364
name: establishment of terminal gap gene boundary
namespace: biological_process
def: "Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0007362 ! terminal region determination

[Term]
id: GO:0007365
name: periodic partitioning
namespace: biological_process
def: "The regionalization process that divides the spatial regions of an embryo into serially repeated regions." [GOC:dph, GOC:isa_complete, GOC:ma]
comment: Note that examples of periodic partitions are tagmata, segments or parasegments.
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007350 ! blastoderm segmentation

[Term]
id: GO:0007366
name: periodic partitioning by pair rule gene
namespace: biological_process
def: "Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
is_a: GO:0007365 ! periodic partitioning

[Term]
id: GO:0007367
name: segment polarity determination
namespace: biological_process
def: "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238]
is_a: GO:0007365 ! periodic partitioning

[Term]
id: GO:0007368
name: determination of left/right symmetry
namespace: biological_process
def: "The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jic]
is_a: GO:0009855 ! determination of bilateral symmetry

[Term]
id: GO:0007369
name: gastrulation
namespace: biological_process
def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [http://cancerweb.ncl.ac.uk/]
xref: Wikipedia:Gastrulation
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0007370
name: ventral furrow formation
namespace: biological_process
def: "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007371
name: ventral midline determination
namespace: biological_process
def: "The regionalization process by which the area where the ventral furrow will begin invagination is specified." [GOC:dph, GOC:isa_complete]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007370 ! ventral furrow formation

[Term]
id: GO:0007372
name: determination of anterior border of ventral midline
namespace: biological_process
is_a: GO:0007371 ! ventral midline determination

[Term]
id: GO:0007373
name: determination of posterior border of ventral midline
namespace: biological_process
is_a: GO:0007371 ! ventral midline determination

[Term]
id: GO:0007374
name: posterior midgut invagination
namespace: biological_process
def: "Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior." [ISBN:08795694238]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007375
name: anterior midgut invagination
namespace: biological_process
def: "Internalization of the anterior midgut into the interior of the embryo." [ISBN:08795694238]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007376
name: cephalic furrow formation
namespace: biological_process
def: "Formation of a partial necklace of inturning tissue on the lateral sides of the embryo, along the dorsal-ventral axis. This furrow demarcates head from thorax in the developing protostome." [ISBN:08795694238]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007377
name: germ-band extension
namespace: biological_process
def: "Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:08795694238]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007378
name: amnioserosa formation
namespace: biological_process
def: "Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift." [ISBN:08795694238]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0010004 ! gastrulation involving germ band extension

[Term]
id: GO:0007379
name: segment specification
namespace: biological_process
def: "The process whereby segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0009880 ! embryonic pattern specification
relationship: part_of GO:0035282 ! segmentation

[Term]
id: GO:0007380
name: specification of segmental identity, head
namespace: biological_process
def: "The specification of the characteristic structures of the head segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
is_a: GO:0007379 ! segment specification
relationship: part_of GO:0035287 ! head segmentation

[Term]
id: GO:0007381
name: specification of segmental identity, labial segment
namespace: biological_process
def: "The specification of the characteristic structures of the labial segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
comment: See also the fly_anatomy.ontology term 'labial segment ; FBbt:00000014'.
is_a: GO:0007380 ! specification of segmental identity, head
relationship: part_of GO:0035289 ! posterior head segmentation

[Term]
id: GO:0007382
name: specification of segmental identity, maxillary segment
namespace: biological_process
def: "The specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
comment: See also the fly_anatomy.ontology term 'maxillary segment ; FBbt:00000013'.
is_a: GO:0007380 ! specification of segmental identity, head
relationship: part_of GO:0035289 ! posterior head segmentation

[Term]
id: GO:0007383
name: specification of segmental identity, antennal segment
namespace: biological_process
def: "The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
comment: See also the fly_anatomy.ontology term 'antennal segment ; FBbt:00000009'.
is_a: GO:0007380 ! specification of segmental identity, head
relationship: part_of GO:0035288 ! anterior head segmentation

[Term]
id: GO:0007384
name: specification of segmental identity, thorax
namespace: biological_process
def: "The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
is_a: GO:0035292 ! specification of segmental identity, trunk

[Term]
id: GO:0007385
name: specification of segmental identity, abdomen
namespace: biological_process
def: "The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
is_a: GO:0035292 ! specification of segmental identity, trunk

[Term]
id: GO:0007386
name: compartment pattern formation
namespace: biological_process
def: "The regionalization process by which embryonic segments are divided into compartments that will result in differences in cell differentiation." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
synonym: "compartment specification" RELATED [GOC:dph]
is_a: GO:0009952 ! anterior/posterior pattern formation

[Term]
id: GO:0007387
name: anterior compartment pattern formation
namespace: biological_process
def: "The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
synonym: "anterior compartment pattern specification" RELATED [GOC:dph]
is_a: GO:0007386 ! compartment pattern formation

[Term]
id: GO:0007388
name: posterior compartment specification
namespace: biological_process
def: "The process involved in the specification of cell identity in the posterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0007386 ! compartment pattern formation

[Term]
id: GO:0007389
name: pattern specification process
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125]
synonym: "pattern biosynthesis" RELATED []
synonym: "pattern formation" RELATED []
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0007390
name: germ-band shortening
namespace: biological_process
def: "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138]
synonym: "germ-band retraction" EXACT []
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0007391
name: dorsal closure
namespace: biological_process
def: "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0007392
name: initiation of dorsal closure
namespace: biological_process
def: "Events that occur at the start of dorsal closure." [GOC:bf]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007391 ! dorsal closure

[Term]
id: GO:0007393
name: dorsal closure, leading edge cell fate determination
namespace: biological_process
def: "Process by which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf, GOC:go_curators, PMID:12147138]
is_a: GO:0035028 ! leading edge cell fate determination
relationship: part_of GO:0035029 ! dorsal closure, leading edge cell fate commitment

[Term]
id: GO:0007394
name: dorsal closure, elongation of leading edge cells
namespace: biological_process
def: "The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138]
is_a: GO:0009826 ! unidimensional cell growth
is_a: GO:0016476 ! regulation of embryonic cell shape
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007392 ! initiation of dorsal closure

[Term]
id: GO:0007395
name: dorsal closure, spreading of leading edge cells
namespace: biological_process
def: "Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa." [GOC:bf, PMID:12147138]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0007391 ! dorsal closure

[Term]
id: GO:0007396
name: suture of dorsal opening
namespace: biological_process
def: "Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole." [GOC:bf, PMID:12147138]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007391 ! dorsal closure

[Term]
id: GO:0007397
name: histogenesis and organogenesis
namespace: biological_process
def: "OBSOLETE. The generation of organized tissues or of whole organs." [GOC:ems]
comment: This term was made obsolete because more appropriate terms were created.
is_obsolete: true
consider: GO:0009887
consider: GO:0009888

[Term]
id: GO:0007398
name: ectoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0007399
name: nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh]
synonym: "pan-neural process" RELATED []
is_a: GO:0048731 ! system development

[Term]
id: GO:0007400
name: neuroblast fate determination
namespace: biological_process
alt_id: GO:0007408
alt_id: GO:0043347
alt_id: GO:0043348
def: "Process by which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators]
synonym: "neuroblast cell fate determination" EXACT []
synonym: "neuroblast identity determination" EXACT []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0014017 ! neuroblast fate commitment

[Term]
id: GO:0007401
name: pan-neural process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because its meaning is ambiguous.
is_obsolete: true
consider: GO:0007399
consider: GO:0050877

[Term]
id: GO:0007402
name: ganglion mother cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
is_a: GO:0001709 ! cell fate determination

[Term]
id: GO:0007403
name: glial cell fate determination
namespace: biological_process
alt_id: GO:0043361
def: "Process by which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0021781 ! glial cell fate commitment

[Term]
id: GO:0007405
name: neuroblast proliferation
namespace: biological_process
alt_id: GO:0043349
alt_id: GO:0043350
def: "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart]
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0007406
name: negative regulation of neuroblast proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the proliferation of neuroblasts." [GOC:ai]
synonym: "down regulation of neuroblast proliferation" EXACT []
synonym: "down-regulation of neuroblast proliferation" EXACT []
synonym: "downregulation of neuroblast proliferation" EXACT []
synonym: "inhibition of neuroblast proliferation" NARROW []
synonym: "suppression of neuroblast proliferation" EXACT []
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0050768 ! negative regulation of neurogenesis
relationship: negatively_regulates GO:0007405 ! neuroblast proliferation

[Term]
id: GO:0007407
name: neuroblast activation
namespace: biological_process
alt_id: GO:0043351
alt_id: GO:0043352
def: "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001775 ! cell activation
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0007409
name: axonogenesis
namespace: biological_process
alt_id: GO:0007410
def: "Generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:jic, http://cancerweb.ncl.ac.uk]
synonym: "axon growth" NARROW []
synonym: "neuron long process generation" EXACT systematic_synonym []
is_a: GO:0048812 ! neuron projection morphogenesis
relationship: part_of GO:0048667 ! cell morphogenesis involved in neuron differentiation

[Term]
id: GO:0007411
name: axon guidance
namespace: biological_process
alt_id: GO:0008040
def: "The process by which the migration of an axon growth cone is directed to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
synonym: "axon chemotaxis" RELATED [GOC:curators]
synonym: "axon growth cone guidance" NARROW []
synonym: "axon pathfinding" EXACT [GOC:mah]
xref: Reactome:422475 "Axon guidance"
xref: Reactome:448661 "Axon guidance"
xref: Reactome:469789 "Axon guidance"
xref: Reactome:487483 "Axon guidance"
xref: Reactome:507443 "Axon guidance"
xref: Reactome:517447 "Axon guidance"
xref: Reactome:526321 "Axon guidance"
xref: Reactome:531371 "Axon guidance"
xref: Reactome:536747 "Axon guidance"
xref: Reactome:542496 "Axon guidance"
xref: Reactome:547823 "Axon guidance"
xref: Reactome:552391 "Axon guidance"
xref: Reactome:557996 "Axon guidance"
xref: Reactome:568647 "Axon guidance"
xref: Reactome:581851 "Axon guidance"
xref: Reactome:592757 "Axon guidance"
xref: Reactome:595492 "Axon guidance"
xref: Wikipedia:Axon_guidance
is_a: GO:0006928 ! cellular component movement
relationship: part_of GO:0007409 ! axonogenesis

[Term]
id: GO:0007412
name: axon target recognition
namespace: biological_process
def: "The process by which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437]
is_a: GO:0007154 ! cell communication
relationship: part_of GO:0007409 ! axonogenesis

[Term]
id: GO:0007413
name: axonal fasciculation
namespace: biological_process
def: "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh]
synonym: "fasciculation of neuron" RELATED []
is_a: GO:0008038 ! neuron recognition
relationship: part_of GO:0007409 ! axonogenesis

[Term]
id: GO:0007414
name: axonal defasciculation
namespace: biological_process
def: "Separation of axons away from a bundle of axons known as a fascicle." [GOC:dgh, ISBN:039751820X]
synonym: "defasciculation of neuron" RELATED []
is_a: GO:0008038 ! neuron recognition
relationship: part_of GO:0007409 ! axonogenesis

[Term]
id: GO:0007415
name: defasciculation of motor neuron axon
namespace: biological_process
def: "Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh]
is_a: GO:0007414 ! axonal defasciculation

[Term]
id: GO:0007416
name: synapse assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah]
synonym: "synapse biogenesis" EXACT [GOC:mah]
synonym: "synaptogenesis" EXACT [GOC:mah]
xref: Wikipedia:Synaptogenesis
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0050808 ! synapse organization
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0007417
name: central nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jic, ISBN:0582227089]
synonym: "CNS development" EXACT []
xref: Wikipedia:Neural_development
is_a: GO:0048731 ! system development
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0007418
name: ventral midline development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0007419
name: ventral cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html]
is_a: GO:0048513 ! organ development
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0007420
name: brain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0048513 ! organ development
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0007421
name: stomatogastric nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure." [GOC:jic]
is_a: GO:0048731 ! system development
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0007422
name: peripheral nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, http://cancerweb.ncl.ac.uk]
is_a: GO:0048731 ! system development
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0007423
name: sensory organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators]
synonym: "sense organ development" EXACT [GOC:dph]
is_a: GO:0048513 ! organ development

[Term]
id: GO:0007424
name: open tracheal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828]
comment: See also the fly_anatomy.ontology term 'tracheal system ; FBbt:00005024'.
is_a: GO:0060541 ! respiratory system development

[Term]
id: GO:0007425
name: epithelial cell fate determination, open tracheal system
namespace: biological_process
alt_id: GO:0046846
def: "Process by which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940]
synonym: "tracheal cell fate determination" BROAD []
synonym: "tracheal epithelial cell fate determination" EXACT []
synonym: "tracheal placode cell fate determination" RELATED []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0007426
name: tracheal outgrowth, open tracheal system
namespace: biological_process
def: "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0007427
name: epithelial cell migration, open tracheal system
namespace: biological_process
def: "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "tracheal cell migration" BROAD []
synonym: "tracheal epithelial cell migration" RELATED []
is_a: GO:0010631 ! epithelial cell migration
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0007428
name: primary branching, open tracheal system
namespace: biological_process
def: "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
synonym: "primary tracheal branching" EXACT []
is_a: GO:0060446 ! branching involved in open tracheal system development

[Term]
id: GO:0007429
name: secondary branching, open tracheal system
namespace: biological_process
def: "Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
synonym: "secondary tracheal branching" EXACT []
is_a: GO:0060446 ! branching involved in open tracheal system development

[Term]
id: GO:0007430
name: terminal branching, open tracheal system
namespace: biological_process
def: "Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html]
synonym: "terminal branching of trachea, cytoplasmic projection extension" EXACT []
is_a: GO:0060446 ! branching involved in open tracheal system development

[Term]
id: GO:0007431
name: salivary gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035272 ! exocrine system development

[Term]
id: GO:0007432
name: salivary gland boundary specification
namespace: biological_process
def: "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957]
synonym: "salivary gland determination" EXACT []
is_a: GO:0010160 ! formation of organ boundary
relationship: part_of GO:0007431 ! salivary gland development

[Term]
id: GO:0007433
name: larval salivary gland boundary specification
namespace: biological_process
def: "Determination in a larval organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957]
synonym: "larval salivary gland determination" BROAD [GOC:tb]
is_a: GO:0007432 ! salivary gland boundary specification
relationship: part_of GO:0002168 ! instar larval development

[Term]
id: GO:0007434
name: adult salivary gland boundary specification
namespace: biological_process
def: "Determination in an adult organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957]
synonym: "larval salivary gland determination" BROAD [GOC:tb]
is_a: GO:0007432 ! salivary gland boundary specification

[Term]
id: GO:0007435
name: salivary gland morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the salivary gland are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic]
is_a: GO:0022612 ! gland morphogenesis
relationship: part_of GO:0007431 ! salivary gland development

[Term]
id: GO:0007436
name: larval salivary gland morphogenesis
namespace: biological_process
def: "The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic]
is_a: GO:0007435 ! salivary gland morphogenesis
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0002168 ! instar larval development

[Term]
id: GO:0007437
name: adult salivary gland morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the adult salivary gland are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0007435 ! salivary gland morphogenesis

[Term]
id: GO:0007438
name: oenocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0001742 ! oenocyte differentiation

[Term]
id: GO:0007439
name: ectodermal gut development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure. The ectodermal gut includes those portions of the gut that are derived from ectoderm." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0048565 ! gut development

[Term]
id: GO:0007440
name: foregut morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the foregut are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048567 ! ectodermal gut morphogenesis

[Term]
id: GO:0007441
name: anterior midgut (ectodermal) morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the anterior midgut (ectodermal) are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0048567 ! ectodermal gut morphogenesis

[Term]
id: GO:0007442
name: hindgut morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the hindgut are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048567 ! ectodermal gut morphogenesis

[Term]
id: GO:0007443
name: Malpighian tubule morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. Morphogenesis pertains to the creation of form. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089]
comment: See also the fly_anatomy.ontology term 'Malpighian tubule ; FBbt:00005786'.
is_a: GO:0035239 ! tube morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048619 ! embryonic hindgut morphogenesis

[Term]
id: GO:0007444
name: imaginal disc development
namespace: biological_process
def: "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, http://cancerweb.ncl.ac.uk/]
is_a: GO:0048513 ! organ development

[Term]
id: GO:0007445
name: determination of imaginal disc primordium
namespace: biological_process
def: "Allocation of embryonic cells to the imaginal disc founder populations, groups of cells that are committed to contribute to the formation of an imaginal disc compartment." [ISBN:0879694238]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0007444 ! imaginal disc development

[Term]
id: GO:0007446
name: imaginal disc growth
namespace: biological_process
def: "The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jic, PMID:10679387]
is_a: GO:0035265 ! organ growth
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0007444 ! imaginal disc development

[Term]
id: GO:0007447
name: imaginal disc pattern formation
namespace: biological_process
def: "The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jic]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007444 ! imaginal disc development

[Term]
id: GO:0007448
name: anterior/posterior pattern formation, imaginal disc
namespace: biological_process
def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, http://cancerweb.ncl.ac.uk]
is_a: GO:0007447 ! imaginal disc pattern formation
is_a: GO:0009952 ! anterior/posterior pattern formation

[Term]
id: GO:0007449
name: proximal/distal pattern formation, imaginal disc
namespace: biological_process
def: "The establishment, maintenance and elaboration of the proximal/distal axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0007447 ! imaginal disc pattern formation
is_a: GO:0009954 ! proximal/distal pattern formation

[Term]
id: GO:0007450
name: dorsal/ventral pattern formation, imaginal disc
namespace: biological_process
def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jic, http://cancerweb.ncl.ac.uk]
synonym: "dorsal-ventral pattern formation, imaginal disc" EXACT [GOC:mah]
synonym: "dorsoventral pattern formation, imaginal disc" EXACT [GOC:mah]
is_a: GO:0007447 ! imaginal disc pattern formation
is_a: GO:0009953 ! dorsal/ventral pattern formation

[Term]
id: GO:0007451
name: dorsal/ventral lineage restriction, imaginal disc
namespace: biological_process
def: "Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402]
synonym: "dorsal-ventral lineage restriction, imaginal disc" EXACT [GOC:mah]
synonym: "dorsoventral lineage restriction, imaginal disc" EXACT [GOC:mah]
is_a: GO:0035161 ! imaginal disc lineage restriction
relationship: part_of GO:0007450 ! dorsal/ventral pattern formation, imaginal disc

[Term]
id: GO:0007453
name: clypeo-labral disc morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures derived from the clypeo-labral disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a clypeo-labal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the labrum, anterior and posterior cibarial plates, fish trap bristles, epistomal sclerite and clypeus." [GOC:bf, ISBN:0879694238]
synonym: "clypeo-labral disc metamorphosis" EXACT []
synonym: "morphogenesis of structures derived from the clypeo-labral disc" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0007454
name: labial disc morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures derived from the labial disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a labial imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238]
synonym: "labial disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035217 ! labial disc development

[Term]
id: GO:0007455
name: eye-antennal disc morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures derived from the eye-antennal disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
synonym: "eye-antennal disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035214 ! eye-antennal disc development

[Term]
id: GO:0007458
name: progression of morphogenetic furrow during compound eye morphogenesis
namespace: biological_process
def: "The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0007460
name: R8 cell fate commitment
namespace: biological_process
alt_id: GO:0007461
def: "The process whereby the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium." [PMID:3076112, PMID:3937883]
synonym: "restriction of R8 fate" EXACT []
is_a: GO:0001752 ! compound eye photoreceptor fate commitment
relationship: part_of GO:0045465 ! R8 cell differentiation

[Term]
id: GO:0007462
name: R1/R6 cell fate commitment
namespace: biological_process
def: "The process whereby the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
is_a: GO:0001752 ! compound eye photoreceptor fate commitment
relationship: part_of GO:0048052 ! R1/R6 cell differentiation

[Term]
id: GO:0007463
name: R2/R5 cell fate commitment
namespace: biological_process
def: "The process whereby the R2/R5 photoreceptors commit to their cell fate. R2 and R5 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
is_a: GO:0001752 ! compound eye photoreceptor fate commitment
relationship: part_of GO:0048054 ! R2/R5 cell differentiation

[Term]
id: GO:0007464
name: R3/R4 cell fate commitment
namespace: biological_process
def: "The process whereby the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883]
is_a: GO:0001752 ! compound eye photoreceptor fate commitment
relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity
relationship: part_of GO:0048056 ! R3/R4 cell differentiation

[Term]
id: GO:0007465
name: R7 cell fate commitment
namespace: biological_process
def: "The process whereby the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883]
is_a: GO:0001752 ! compound eye photoreceptor fate commitment
relationship: part_of GO:0045466 ! R7 cell differentiation

[Term]
id: GO:0007468
name: regulation of rhodopsin gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of rhodopsin gene expression. This includes transcriptional, translational, or posttranslational regulation." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010468 ! regulation of gene expression
relationship: part_of GO:0042461 ! photoreceptor cell development

[Term]
id: GO:0007469
name: antennal development
namespace: biological_process
def: "The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526]
is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis
relationship: part_of GO:0035214 ! eye-antennal disc development

[Term]
id: GO:0007470
name: prothoracic disc morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures derived from the prothoracic disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a prothoracic imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult humerous and anterior spiracle." [GOC:bf, ISBN:0879694238]
synonym: "prothoracic disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
is_a: GO:0035219 ! prothoracic disc development
is_a: GO:0048569 ! post-embryonic organ development

[Term]
id: GO:0007471
name: prothoracic morphogenesis
namespace: biological_process
def: "OBSOLETE. The process by which the anatomical structures of the first or anterior segment of the insect thorax are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic]
comment: This term was made obsolete because it does not stipulate which anatomical part is involved in the process.
is_obsolete: true
consider: GO:0007470

[Term]
id: GO:0007472
name: wing disc morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures derived from the wing disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
synonym: "wing disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035220 ! wing disc development

[Term]
id: GO:0007473
name: wing disc proximal/distal pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing." [GOC:bf]
is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc
is_a: GO:0035222 ! wing disc pattern formation

[Term]
id: GO:0007474
name: imaginal disc-derived wing vein specification
namespace: biological_process
def: "The regionalization process by which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu]
synonym: "wing vein specification" EXACT []
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0007475
name: apposition of dorsal and ventral imaginal disc-derived wing surfaces
namespace: biological_process
def: "The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu]
synonym: "apposition of dorsal and ventral wing surfaces" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0008587 ! imaginal disc-derived wing margin morphogenesis

[Term]
id: GO:0007476
name: imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the imaginal disc-derived wing are generated and organized. Morphogenesis pertains to the creation of form. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu]
synonym: "wing morphogenesis" EXACT []
is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis
is_a: GO:0035120 ! post-embryonic appendage morphogenesis
relationship: part_of GO:0007472 ! wing disc morphogenesis

[Term]
id: GO:0007477
name: notum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure." [GOC:jic]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035220 ! wing disc development

[Term]
id: GO:0007478
name: leg disc morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures derived from the leg disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
synonym: "leg disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035218 ! leg disc development

[Term]
id: GO:0007479
name: leg disc proximal/distal pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf]
is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc
is_a: GO:0035223 ! leg disc pattern formation

[Term]
id: GO:0007480
name: imaginal disc-derived leg morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a leg derived from an imaginal disc are generated and organized. Morphogenesis pertains to the creation of form. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cancerweb.ncl.ac.uk/]
is_a: GO:0035109 ! imaginal disc-derived limb morphogenesis
is_a: GO:0035110 ! leg morphogenesis
is_a: GO:0035127 ! post-embryonic limb morphogenesis
relationship: part_of GO:0007478 ! leg disc morphogenesis

[Term]
id: GO:0007481
name: haltere disc morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures derived from the haltere disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a haltere imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum." [GOC:bf, ISBN:0879694238]
synonym: "haltere disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035216 ! haltere disc development

[Term]
id: GO:0007482
name: haltere development
namespace: biological_process
def: "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jic, http://www.earthlife.net]
is_a: GO:0048737 ! imaginal disc-derived appendage development
relationship: part_of GO:0035216 ! haltere disc development

[Term]
id: GO:0007483
name: genital disc morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures derived from the genital disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238]
synonym: "genital disc metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0007484
name: imaginal disc-derived genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
synonym: "genital development" BROAD []
is_a: GO:0048806 ! genitalia development
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0007485
name: imaginal disc-derived male genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
synonym: "male genital development" BROAD []
is_a: GO:0007484 ! imaginal disc-derived genitalia development

[Term]
id: GO:0007486
name: imaginal disc-derived female genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu]
synonym: "female genital development" BROAD []
is_a: GO:0007484 ! imaginal disc-derived genitalia development
is_a: GO:0030540 ! female genitalia development

[Term]
id: GO:0007487
name: analia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0007488
name: histoblast morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures derived from the histoblast disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238]
synonym: "histoblast metamorphosis" EXACT []
is_a: GO:0007560 ! imaginal disc morphogenesis

[Term]
id: GO:0007489
name: maintenance of imaginal histoblast diploidy
namespace: biological_process
def: "The negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells." [GOC:bf, ISBN:0879694238]
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: part_of GO:0007488 ! histoblast morphogenesis

[Term]
id: GO:0007490
name: tergite morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the tergite are generated and organized. Morphogenesis pertains to the creation of form. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment." [GOC:jic, http://www.earthlife.net]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0007488 ! histoblast morphogenesis

[Term]
id: GO:0007491
name: sternite morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the sternite are generated and organized. Morphogenesis pertains to the creation of form. The sternite is the plate or sclerite on the underside of a body segment." [GOC:jic, http://www.earthlife.net]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0007488 ! histoblast morphogenesis

[Term]
id: GO:0007492
name: endoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0007493
name: endodermal cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437]
comment: Note that this term was 'endoderm determination'. Changed string to make it more consistent with parent term 'cell fate determination'.
synonym: "endoderm cell fate determination" EXACT []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0001711 ! endodermal cell fate commitment

[Term]
id: GO:0007494
name: midgut development
namespace: biological_process
def: "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0048565 ! gut development

[Term]
id: GO:0007495
name: visceral mesoderm-endoderm interaction involved in midgut development
namespace: biological_process
def: "The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut." [GOC:dph, GOC:isa_complete]
synonym: "visceral mesoderm/endoderm interaction" EXACT []
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0007494 ! midgut development

[Term]
id: GO:0007496
name: anterior midgut development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure." [GOC:jic]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007494 ! midgut development

[Term]
id: GO:0007497
name: posterior midgut development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007494 ! midgut development

[Term]
id: GO:0007498
name: mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0007499
name: ectoderm and mesoderm interaction
namespace: biological_process
def: "A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm." [GOC:isa_complete]
synonym: "ectoderm/mesoderm interaction" EXACT []
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0007498 ! mesoderm development

[Term]
id: GO:0007500
name: mesodermal cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437]
comment: Note that this term was 'mesoderm determination'. Changed string to make more consistent with parent term 'cell fate determination'.
synonym: "mesoderm cell fate determination" EXACT []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0001710 ! mesodermal cell fate commitment

[Term]
id: GO:0007501
name: mesodermal cell fate specification
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
comment: Note that this term was 'fate specification in mesoderm'. String of term was changed to correspond to format of sibling terms 'endoderm cell fate specification' and 'ectoderm cell fate specification'.
synonym: "mesoderm cell fate specification" EXACT []
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0001710 ! mesodermal cell fate commitment

[Term]
id: GO:0007502
name: gut mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gut mesoderm over time, from its formation to the mature structure. The gut mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gut of the organism." [GOC:ai]
is_a: GO:0007498 ! mesoderm development

[Term]
id: GO:0007503
name: fat body development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism." [ISBN:0582227089]
is_a: GO:0048513 ! organ development

[Term]
id: GO:0007504
name: larval fat body development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larval fat body over time, from its formation to the mature structure. The larval fat body consists of a bilaterally symmetrical monolayer of cells lying between the gut and the muscles of the body wall. As in other tissues of the larva, the cells of the fat body complete their divisions in the embryo and increase in size and ploidy during larval life." [GOC:bf, ISBN:0879694238]
is_a: GO:0007503 ! fat body development
is_a: GO:0048569 ! post-embryonic organ development
relationship: part_of GO:0002168 ! instar larval development

[Term]
id: GO:0007505
name: adult fat body development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adult fat body over time, from its formation to the mature structure. Larval fat body cells that remain at eclosion degenerate in the first 2 to 4 days of adult life, leaving behind the smaller cells of the adult fat body." [GOC:bf, ISBN:0879694238]
is_a: GO:0007503 ! fat body development

[Term]
id: GO:0007506
name: gonadal mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0007498 ! mesoderm development
relationship: part_of GO:0008406 ! gonad development

[Term]
id: GO:0007507
name: heart development
namespace: biological_process
alt_id: GO:0007511
def: "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jic, http://cancerweb.ncl.ac.uk]
synonym: "cardiac development" RELATED []
synonym: "dorsal vessel development" NARROW []
xref: Wikipedia:Heart_development
is_a: GO:0048513 ! organ development

[Term]
id: GO:0007508
name: larval heart development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper." [GOC:bf, ISBN:08779694238]
is_a: GO:0007507 ! heart development
is_a: GO:0048569 ! post-embryonic organ development
relationship: part_of GO:0002164 ! larval development

[Term]
id: GO:0007509
name: mesoderm migration
namespace: biological_process
def: "The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism." [GOC:isa_complete]
is_a: GO:0090130 ! tissue migration
relationship: part_of GO:0001707 ! mesoderm formation

[Term]
id: GO:0007510
name: cardioblast cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
is_a: GO:0060913 ! cardiac cell fate determination
relationship: part_of GO:0042684 ! cardioblast cell fate commitment

[Term]
id: GO:0007512
name: adult heart development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure." [GOC:bf]
synonym: "adult cardiac development" RELATED []
is_a: GO:0007507 ! heart development

[Term]
id: GO:0007513
name: pericardial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized mesodermal cell acquires the specialized features of a pericardial cell. In insects, pericardial cells are loosely arranged non-myogenic cells that flank the cardioblasts and probably act in the filtration of hemolymph." [GOC:bf, PMID:12435360]
is_a: GO:0035051 ! cardiac cell differentiation

[Term]
id: GO:0007514
name: garland cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a garland cell, a small group of nephrocytes which take up waste materials from the hemolymph by endocytosis." [PMID:7588884]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0007515
name: lymph gland development
namespace: biological_process
def: "OBSOLETE. The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is a small bean-shaped organ made up of a loose meshwork of reticular tissue in which are enmeshed large numbers of lymphocytes, macrophages and accessory cells. Lymph glands are located along the lymphatic system." [GOC:jic, http://cancerweb.ncl.ac.uk]
comment: This term was made obsolete because it was wrongly defined.
is_obsolete: true
consider: GO:0048535
consider: GO:0048542

[Term]
id: GO:0007516
name: hemocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
synonym: "arthropod blood cell development" EXACT []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0007517
name: muscle organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jic, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0048513 ! organ development

[Term]
id: GO:0007518
name: myoblast cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a myoblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0048625 ! myoblast cell fate commitment

[Term]
id: GO:0007519
name: skeletal muscle tissue development
namespace: biological_process
alt_id: GO:0048637
def: "The developmental sequence of events leading to the formation of adult muscle that occurs in the anima. In vertebrate skeletal muscle the main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle, http://cancerweb.ncl.ac.uk/]
synonym: "myogenesis" RELATED []
is_a: GO:0014706 ! striated muscle tissue development
relationship: part_of GO:0060538 ! skeletal muscle organ development

[Term]
id: GO:0007520
name: myoblast fusion
namespace: biological_process
def: "A process whereby non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk/]
is_a: GO:0000768 ! syncytium formation by plasma membrane fusion
relationship: part_of GO:0014902 ! myotube differentiation

[Term]
id: GO:0007521
name: muscle cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000187, GOC:go_curators]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0007517 ! muscle organ development
relationship: part_of GO:0042693 ! muscle cell fate commitment

[Term]
id: GO:0007522
name: visceral muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0007517 ! muscle organ development

[Term]
id: GO:0007523
name: larval visceral muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jic]
is_a: GO:0007522 ! visceral muscle development
is_a: GO:0048569 ! post-embryonic organ development
relationship: part_of GO:0002164 ! larval development

[Term]
id: GO:0007524
name: adult visceral muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adult visceral muscle over time, from its formation to the mature structure." [GOC:jic]
is_a: GO:0007522 ! visceral muscle development

[Term]
id: GO:0007525
name: somatic muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. This muscle is found in Nematodes." [GOC:jic, GOC:mtg_muscle]
is_a: GO:0007517 ! muscle organ development

[Term]
id: GO:0007526
name: larval somatic muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jic]
is_a: GO:0007525 ! somatic muscle development
is_a: GO:0048569 ! post-embryonic organ development
relationship: part_of GO:0002164 ! larval development

[Term]
id: GO:0007527
name: adult somatic muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jic]
is_a: GO:0007525 ! somatic muscle development

[Term]
id: GO:0007528
name: neuromuscular junction development
namespace: biological_process
def: "The process whose specific outcome is the progression of the neuromuscular junction over time, from its formation to the mature structure." [GOC:jic]
is_a: GO:0050808 ! synapse organization
relationship: part_of GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0007529
name: establishment of synaptic specificity at neuromuscular junction
namespace: biological_process
def: "The biological process by which a synapse between a motor neuron and a muscle is initially formed." [GOC:isa_complete]
is_a: GO:0050808 ! synapse organization
relationship: part_of GO:0007528 ! neuromuscular junction development

[Term]
id: GO:0007530
name: sex determination
namespace: biological_process
def: "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: Wikipedia:Sex-determination_system
is_a: GO:0003006 ! reproductive developmental process

[Term]
id: GO:0007531
name: mating type determination
namespace: biological_process
def: "Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms." [http://www.biology-text.com/]
is_a: GO:0007530 ! sex determination
is_a: GO:0045165 ! cell fate commitment
is_a: GO:0048610 ! reproductive cellular process

[Term]
id: GO:0007532
name: regulation of transcription, mating-type specific
namespace: biological_process
def: "Any mating-type specific process that modulates the frequency, rate or extent of transcription." [GOC:go_curators]
synonym: "mating-type specific transcriptional control" EXACT []
is_a: GO:0006355 ! regulation of transcription, DNA-dependent
is_a: GO:0007531 ! mating type determination

[Term]
id: GO:0007533
name: mating type switching
namespace: biological_process
def: "The conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [PMID:9928492]
synonym: "mating type switching and recombination" RELATED []
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0007531 ! mating type determination
is_a: GO:0022413 ! reproductive process in single-celled organism

[Term]
id: GO:0007534
name: gene conversion at mating-type locus
namespace: biological_process
def: "The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged." [GOC:elh, PMID:9928492]
is_a: GO:0006312 ! mitotic recombination
relationship: part_of GO:0007533 ! mating type switching

[Term]
id: GO:0007535
name: donor selection
namespace: biological_process
def: "The process by which a cell uses one locus in preference to another as the donor in mating type switching." [GOC:mah, PMID:9928492]
synonym: "donor preference" RELATED []
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0007533 ! mating type switching

[Term]
id: GO:0007536
name: activation of recombination (HML)
namespace: biological_process
def: "The activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492]
is_a: GO:0007535 ! donor selection
is_a: GO:0045911 ! positive regulation of DNA recombination

[Term]
id: GO:0007537
name: inactivation of recombination (HML)
namespace: biological_process
def: "The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492]
is_a: GO:0007535 ! donor selection
is_a: GO:0045910 ! negative regulation of DNA recombination

[Term]
id: GO:0007538
name: primary sex determination
namespace: biological_process
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0007539
name: primary sex determination, soma
namespace: biological_process
def: "The transmission of information about sexual status from the initial, general, determination to signals specific to the soma." [GOC:ems]
is_a: GO:0007538 ! primary sex determination
relationship: part_of GO:0018993 ! somatic sex determination

[Term]
id: GO:0007540
name: sex determination, establishment of X:A ratio
namespace: biological_process
def: "The developmental process by which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it." [GOC:isa_complete]
is_a: GO:0003006 ! reproductive developmental process
relationship: part_of GO:0007539 ! primary sex determination, soma

[Term]
id: GO:0007541
name: sex determination, primary response to X:A ratio
namespace: biological_process
def: "The developmental process by which an organism interprets its X to autosomal chromosomal complement." [GOC:isa_complete]
is_a: GO:0003006 ! reproductive developmental process
relationship: part_of GO:0007539 ! primary sex determination, soma

[Term]
id: GO:0007542
name: primary sex determination, germ-line
namespace: biological_process
def: "The transmission of information about sexual status, from the initial general determination, to signals specific to the germ-line." [GOC:ems]
is_a: GO:0007538 ! primary sex determination
relationship: part_of GO:0018992 ! germ-line sex determination

[Term]
id: GO:0007543
name: sex determination, somatic-gonadal interaction
namespace: biological_process
def: "The process that mediates the interactions between somatic cells and gonadal cells that ultimately results in the specification of sexual status of the organism." [GOC:isa_complete]
synonym: "sex determination, somatic/gonadal interaction" EXACT []
is_a: GO:0007154 ! cell communication
relationship: part_of GO:0007542 ! primary sex determination, germ-line

[Term]
id: GO:0007545
name: processes downstream of sex determination signal
namespace: biological_process
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0007546
name: somatic processes downstream of sex determination signal
namespace: biological_process
def: "The events determining the somatic sexual phenotype after the initial transmission of that phenotype to soma-specific information pathways." [GOC:ems]
is_a: GO:0007545 ! processes downstream of sex determination signal

[Term]
id: GO:0007547
name: germ-line processes downstream of sex determination signal
namespace: biological_process
def: "The events determining the germ-line sexual phenotype after the initial transmission of that phenotype to germ-line-specific information pathways." [GOC:ems]
is_a: GO:0007545 ! processes downstream of sex determination signal
relationship: part_of GO:0018992 ! germ-line sex determination

[Term]
id: GO:0007548
name: sex differentiation
namespace: biological_process
def: "The establishment of the sex of an organism by physical differentiation." [GOC:ai]
xref: Wikipedia:Sexual_differentiation
is_a: GO:0003006 ! reproductive developmental process

[Term]
id: GO:0007549
name: dosage compensation
namespace: biological_process
def: "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes." [GOC:ems, ISBN:0140512888, PMID:11498577]
xref: Wikipedia:Dosage_compensation
is_a: GO:0040029 ! regulation of gene expression, epigenetic

[Term]
id: GO:0007550
name: establishment of dosage compensation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:isa_complete]
comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms.
is_obsolete: true
consider: GO:0007549

[Term]
id: GO:0007551
name: maintenance of dosage compensation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:isa_complete]
comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms.
is_obsolete: true
consider: GO:0007549

[Term]
id: GO:0007552
name: metamorphosis
namespace: biological_process
alt_id: GO:0046698
alt_id: GO:0046699
def: "A biological process by which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. For example the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
xref: Wikipedia:Metamorphosis
is_a: GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0007553
name: regulation of ecdysteroid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "regulation of ecdysteroid metabolism" EXACT []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
is_a: GO:0048580 ! regulation of post-embryonic development
relationship: regulates GO:0045455 ! ecdysteroid metabolic process

[Term]
id: GO:0007554
name: regulation of ecdysteroid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators]
synonym: "regulation of ecdysteroid anabolism" EXACT []
synonym: "regulation of ecdysteroid biosynthesis" EXACT []
synonym: "regulation of ecdysteroid formation" EXACT []
synonym: "regulation of ecdysteroid synthesis" EXACT []
is_a: GO:0007553 ! regulation of ecdysteroid metabolic process
is_a: GO:0010566 ! regulation of ketone biosynthetic process
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process
relationship: regulates GO:0045456 ! ecdysteroid biosynthetic process

[Term]
id: GO:0007555
name: regulation of ecdysteroid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of ecdysteroid from a cell or group of cells." [GOC:go_curators]
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0045457 ! ecdysteroid secretion

[Term]
id: GO:0007556
name: regulation of juvenile hormone metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators]
synonym: "regulation of juvenile hormone metabolism" EXACT []
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
is_a: GO:0043455 ! regulation of secondary metabolic process
relationship: part_of GO:0002165 ! instar larval or pupal development
relationship: regulates GO:0006716 ! juvenile hormone metabolic process

[Term]
id: GO:0007557
name: regulation of juvenile hormone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators]
synonym: "regulation of juvenile hormone anabolism" EXACT []
synonym: "regulation of juvenile hormone biosynthesis" EXACT []
synonym: "regulation of juvenile hormone formation" EXACT []
synonym: "regulation of juvenile hormone synthesis" EXACT []
is_a: GO:0007556 ! regulation of juvenile hormone metabolic process
is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: regulates GO:0006718 ! juvenile hormone biosynthetic process

[Term]
id: GO:0007558
name: regulation of juvenile hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of juvenile hormone secretion." [GOC:go_curators]
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0045443 ! juvenile hormone secretion

[Term]
id: GO:0007559
name: histolysis
namespace: biological_process
def: "The breakdown of tissues; usually, if not always, accompanied by cell death, followed by the complete dissolution of dead tissue." [GOC:dph, GOC:ma]
xref: Wikipedia:Histolysis
is_a: GO:0016271 ! tissue death
relationship: part_of GO:0009888 ! tissue development

[Term]
id: GO:0007560
name: imaginal disc morphogenesis
namespace: biological_process
alt_id: GO:0007452
def: "The process by which the anatomical structures derived from an imaginal disc are generated and organized. Morphogenesis pertains to the creation of form. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jic]
synonym: "imaginal disc metamorphosis" EXACT []
is_a: GO:0048563 ! post-embryonic organ morphogenesis
relationship: part_of GO:0007444 ! imaginal disc development
relationship: part_of GO:0007552 ! metamorphosis
relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis

[Term]
id: GO:0007561
name: imaginal disc eversion
namespace: biological_process
def: "The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0007560 ! imaginal disc morphogenesis

[Term]
id: GO:0007562
name: eclosion
namespace: biological_process
def: "The emergence of an adult insect from a pupa case." [GOC:dgh, GOC:dos, GOC:mah, ISBN:0198600461]
xref: Wikipedia:Pupa#Emergence
is_a: GO:0071684 ! organism emergence from protective structure
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0007563
name: regulation of eclosion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg." [GOC:go_curators, ISBN:0198600461]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0007562 ! eclosion

[Term]
id: GO:0007564
name: regulation of chitin-based cuticle tanning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jic, GOC:mtg_sensu]
synonym: "regulation of cuticle hardening" NARROW []
synonym: "regulation of cuticle tanning" EXACT []
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0007593 ! chitin-based cuticle tanning

[Term]
id: GO:0007565
name: female pregnancy
namespace: biological_process
def: "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." [ISBN:0192800825]
synonym: "carrying of young" RELATED []
synonym: "gestation" EXACT []
xref: Wikipedia:Gestation
is_a: GO:0022414 ! reproductive process
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0007566
name: embryo implantation
namespace: biological_process
def: "Attachment of the blastocyst to the uterine lining." [GOC:isa_complete, http://www.medterms.com]
synonym: "blastocyst implantation" EXACT []
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0007275 ! multicellular organismal development
relationship: part_of GO:0007565 ! female pregnancy

[Term]
id: GO:0007567
name: parturition
namespace: biological_process
def: "The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "egg laying" NARROW []
synonym: "giving birth" EXACT []
is_a: GO:0022414 ! reproductive process
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0007568
name: aging
namespace: biological_process
alt_id: GO:0016280
def: "The inherent decline over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility." [GOC:dph, GOC:ems]
synonym: "ageing" EXACT []
xref: Wikipedia:AgingSenescence
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0007569
name: cell aging
namespace: biological_process
def: "Progression of the cell from its inception to the end of its lifespan." [GOC:jh, PMID:12044934]
synonym: "cell ageing" EXACT []
synonym: "cellular senescence" EXACT []
xref: Wikipedia:Senescence#Cellular_senescence
is_a: GO:0007568 ! aging
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0007570
name: age dependent accumulation of genetic damage
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not describe a biological process.
is_obsolete: true
consider: GO:0001301

[Term]
id: GO:0007571
name: age-dependent general metabolic decline
namespace: biological_process
def: "The process arising as the cell progresses toward the end of its lifespan that cause changes cellular metabolism, resulting in a decline in cell function; for example, a decline in the efficiency of protein synthesis." [GOC:jh, PMID:9891807]
synonym: "age-dependent decreased translational activity" NARROW []
synonym: "age-dependent increased protein content" NARROW []
synonym: "age-dependent yeast cell size increase" RELATED []
synonym: "nucleolar size increase" NARROW []
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0007568 ! aging

[Term]
id: GO:0007572
name: age dependent decreased translational activity
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not describe a biological process.
is_obsolete: true
consider: GO:0007571

[Term]
id: GO:0007573
name: age dependent increased protein content
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not describe a biological process.
is_obsolete: true
consider: GO:0007571

[Term]
id: GO:0007574
name: cell aging (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. Process associated with continued cell division (budding) by the mother cell. Age is often measured by counting the number of bud scars on the cell." [GOC:sgd_curators]
comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'.
is_obsolete: true
replaced_by: GO:0007569

[Term]
id: GO:0007575
name: nucleolar size increase
namespace: biological_process
def: "OBSOLETE. The process of nucleolar expansion." [GOC:ai]
comment: This term was made obsolete because it does not describe a biological process.
is_obsolete: true
consider: GO:0007571
consider: GO:0007576

[Term]
id: GO:0007576
name: nucleolar fragmentation
namespace: biological_process
alt_id: GO:0046616
synonym: "nucleolar size increase" RELATED []
is_a: GO:0007000 ! nucleolus organization
relationship: part_of GO:0007569 ! cell aging

[Term]
id: GO:0007577
name: autophagic death (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. This process is a type of programmed cell death pathway similar to apoptosis and necrosis observed in multicellular organisms. It is characterized by cellular enlargement (necrosis) and presence of many autophagic bodies along with degradation of cellular components (nucleus, Golgi, ER), protein, DNA and RNA." [GOC:sgd_curators]
comment: This term was made obsolete because a more correct term has been created.
is_obsolete: true
consider: GO:0048102

[Term]
id: GO:0007578
name: aging dependent sterility (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. A haploid's inability to mate due to the loss of silencing at the mating-type loci, resulting in expression of both of the normally silent mating-type cassettes." [GOC:sgd_curators]
comment: This term was made obsolete because it reflected a trait or phenotype.
is_obsolete: true
consider: GO:0030466

[Term]
id: GO:0007579
name: senescence factor accumulation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jh]
comment: This term was made obsolete because it does not represent a process.
is_obsolete: true

[Term]
id: GO:0007580
name: extrachromosomal circular DNA accumulation during cell aging
namespace: biological_process
def: "Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication." [GOC:jh, PMID:9891807]
comment: Note that the term string was changed to be consistent with placement of this term in cell aging hierarchy.
synonym: "extrachromosomal circular DNA accumulation during cell ageing" EXACT []
is_a: GO:0001301 ! progressive alteration of chromatin during cell aging

[Term]
id: GO:0007581
name: age-dependent yeast cell size increase
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:sgd_curators]
comment: This term was made obsolete because it does not describe a biological process.
is_obsolete: true
consider: GO:0007571

[Term]
id: GO:0007583
name: killer activity
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it is ambiguous; 'killer activity' could refer to several different processes.
is_obsolete: true
consider: GO:0042267

[Term]
id: GO:0007584
name: response to nutrient
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators]
subset: gosubset_prok
synonym: "nutritional response pathway" NARROW []
synonym: "response to nutrients" EXACT []
is_a: GO:0031667 ! response to nutrient levels
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0007585
name: respiratory gaseous exchange
namespace: biological_process
def: "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "breathing" BROAD []
synonym: "respiration" BROAD []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0007586
name: digestion
namespace: biological_process
def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
xref: Wikipedia:Digestion
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0007587
name: sugar utilization
namespace: biological_process
is_a: GO:0007586 ! digestion

[Term]
id: GO:0007588
name: excretion
namespace: biological_process
def: "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." [ISBN:0192801023]
subset: goslim_pir
xref: Wikipedia:Excretion
is_a: GO:0003008 ! system process
is_a: GO:0046903 ! secretion

[Term]
id: GO:0007589
name: body fluid secretion
namespace: biological_process
def: "The controlled release of a fluid by a cell or group of cells in a multicellular organism." [GOC:ai, GOC:dph, GOC:tb]
is_a: GO:0046903 ! secretion
is_a: GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0007590
name: fat body metabolic process (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving the fat body. A fat body is a fat-containing cellular structure which serves as an energy reserve. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents metabolism within the fat body not of the fat body.
is_obsolete: true
consider: GO:0008152
consider: GO:0015032

[Term]
id: GO:0007591
name: molting cycle, chitin-based cuticle
namespace: biological_process
def: "The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0018988 ! molting cycle, protein-based cuticle

[Term]
id: GO:0007592
name: protein-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this is found in Caenorhabditis elegans." [GOC:ems, GOC:mtg_sensu]
synonym: "protein-based cuticle anabolism" EXACT []
synonym: "protein-based cuticle biosynthetic process" EXACT []
synonym: "protein-based cuticle formation" EXACT []
synonym: "protein-based cuticle synthesis" EXACT []
is_a: GO:0042335 ! cuticle development

[Term]
id: GO:0007593
name: chitin-based cuticle tanning
namespace: biological_process
alt_id: GO:0045452
def: "The cross-linking of chitin and other cuticle proteins, rendering them insoluble and hardening the cuticle. This process generally darkens the color of the cuticle." [GOC:bf, GOC:jic, GOC:mtg_sensu]
synonym: "cuticle hardening" NARROW []
is_a: GO:0021700 ! developmental maturation
is_a: GO:0040006 ! protein-based cuticle attachment to epithelium
relationship: part_of GO:0008365 ! adult chitin-based cuticle development

[Term]
id: GO:0007594
name: puparial adhesion
namespace: biological_process
def: "The adhesion of the puparia of Diptera to their substrate; normally effected by a 'glue' secreted by the larval salivary gland and expectorated at the time of pupariation." [GOC:ma]
synonym: "puparial glue" RELATED []
is_a: GO:0022609 ! multicellular organism adhesion to substrate
relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle

[Term]
id: GO:0007595
name: lactation
namespace: biological_process
def: "The secretion of milk by the mammary gland." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: Wikipedia:Lactation
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0007596
name: blood coagulation
namespace: biological_process
def: "The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." [http://www.graylab.ac.uk/omd/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "blood clotting" EXACT []
xref: Reactome:109582 "Hemostasis"
xref: Reactome:140875 "Common Pathway"
xref: Reactome:140877 "Formation of Fibrin Clot (Clotting Cascade)"
xref: Reactome:448662 "Common Pathway"
xref: Reactome:448663 "Formation of Fibrin Clot (Clotting Cascade)"
xref: Reactome:448664 "Hemostasis"
xref: Reactome:469790 "Common Pathway"
xref: Reactome:469791 "Formation of Fibrin Clot (Clotting Cascade)"
xref: Reactome:469792 "Hemostasis"
xref: Reactome:487484 "Common Pathway"
xref: Reactome:487485 "Formation of Fibrin Clot (Clotting Cascade)"
xref: Reactome:487486 "Hemostasis"
xref: Reactome:507444 "Common Pathway"
xref: Reactome:507445 "Formation of Fibrin Clot (Clotting Cascade)"
xref: Reactome:507446 "Hemostasis"
xref: Reactome:517474 "Hemostasis"
xref: Reactome:517807 "Formation of Fibrin Clot (Clotting Cascade)"
xref: Reactome:526344 "Hemostasis"
xref: Reactome:531176 "Hemostasis"
xref: Reactome:536770 "Hemostasis"
xref: Reactome:542272 "Hemostasis"
xref: Reactome:547847 "Hemostasis"
xref: Reactome:552419 "Hemostasis"
xref: Reactome:558028 "Hemostasis"
xref: Reactome:568678 "Hemostasis"
xref: Reactome:581881 "Hemostasis"
xref: Reactome:585935 "Hemostasis"
xref: Reactome:592656 "Hemostasis"
xref: Reactome:595510 "Hemostasis"
xref: Reactome:597409 "Hemostasis"
xref: Reactome:599753 "Hemostasis"
xref: Reactome:600652 "Hemostasis"
xref: Reactome:602615 "Hemostasis"
xref: Wikipedia:Coagulation
is_a: GO:0007599 ! hemostasis
is_a: GO:0050817 ! coagulation
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0007597
name: blood coagulation, intrinsic pathway
namespace: biological_process
def: "A pathway of blood coagulation that occurs during the clotting of platelet-poor plasma, in which activation of factor X to factor Xa is effected by the combination of factor IXa + factor VIIIa + calcium ion + phospholipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: See also the biological process term 'blood coagulation, extrinsic pathway ; GO:0007598'.
xref: Reactome:140837 "Intrinsic Pathway"
xref: Reactome:449090 "Intrinsic Pathway"
xref: Reactome:470202 "Intrinsic Pathway"
xref: Reactome:487889 "Intrinsic Pathway"
xref: Reactome:507861 "Intrinsic Pathway"
xref: Reactome:517806 "Intrinsic Pathway"
is_a: GO:0007596 ! blood coagulation

[Term]
id: GO:0007598
name: blood coagulation, extrinsic pathway
namespace: biological_process
def: "A pathway of blood coagulation in which the earlier stages of the cascade are bypassed and the activation of factor X to factor Xa is effected by the combination of factor VIIa + thromboplastin; this second pathway occurs when tissue extracts are present in optimal amounts and is much more rapid than the intrinsic pathway." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'.
xref: Reactome:140834 "Extrinsic Pathway"
xref: Reactome:449091 "Extrinsic Pathway"
xref: Reactome:470203 "Extrinsic Pathway"
xref: Reactome:487890 "Extrinsic Pathway"
xref: Reactome:507860 "Extrinsic Pathway"
is_a: GO:0007596 ! blood coagulation

[Term]
id: GO:0007599
name: hemostasis
namespace: biological_process
def: "The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: Wikipedia:Hemostasis
is_a: GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0007600
name: sensory perception
namespace: biological_process
def: "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph]
xref: Wikipedia:Perception
is_a: GO:0050890 ! cognition

[Term]
id: GO:0007601
name: visual perception
namespace: biological_process
def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai]
synonym: "sense of sight" EXACT []
synonym: "sensory visual perception" EXACT []
synonym: "vision" EXACT []
xref: Wikipedia:Visual_perception
is_a: GO:0050953 ! sensory perception of light stimulus

[Term]
id: GO:0007602
name: phototransduction
namespace: biological_process
def: "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators]
subset: gosubset_prok
synonym: "opsin" RELATED []
synonym: "phototransduction, visible light, light adaptation" NARROW []
synonym: "phototrophin mediated phototransduction" NARROW []
xref: Wikipedia:Visual_phototransduction
is_a: GO:0007165 ! signal transduction
is_a: GO:0009583 ! detection of light stimulus
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0007603
name: phototransduction, visible light
namespace: biological_process
def: "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0007602 ! phototransduction
is_a: GO:0009584 ! detection of visible light

[Term]
id: GO:0007604
name: phototransduction, UV
namespace: biological_process
def: "The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "phototransduction, ultraviolet light" EXACT []
synonym: "phototransduction, ultraviolet radiation" EXACT []
synonym: "phototransduction, UV light" EXACT []
synonym: "phototransduction, UV radiation" EXACT []
synonym: "UV-sensitive opsin" RELATED []
is_a: GO:0007602 ! phototransduction
is_a: GO:0009589 ! detection of UV
is_a: GO:0034644 ! cellular response to UV

[Term]
id: GO:0007605
name: sensory perception of sound
namespace: biological_process
def: "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai]
synonym: "hearing" EXACT []
synonym: "perception of sound" EXACT []
xref: Wikipedia:Hearing_(sense)
is_a: GO:0050954 ! sensory perception of mechanical stimulus

[Term]
id: GO:0007606
name: sensory perception of chemical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "chemosensory perception" EXACT []
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0007607
name: taste perception
namespace: biological_process
def: "OBSOLETE. The series of events required for the chemical composition of a soluble stimulus to be received and converted to a molecular signal." [GOC:jl, ISBN:0395825172]
comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage.
is_obsolete: true
consider: GO:0050909
consider: GO:0050912

[Term]
id: GO:0007608
name: sensory perception of smell
namespace: biological_process
def: "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/]
synonym: "olfaction" EXACT []
synonym: "scent perception" EXACT []
synonym: "sense of smell" EXACT []
synonym: "smell perception" EXACT []
xref: Wikipedia:Olfaction
is_a: GO:0007606 ! sensory perception of chemical stimulus

[Term]
id: GO:0007610
name: behavior
namespace: biological_process
def: "The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:ems, ISBN:0395448956]
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: gosubset_prok
synonym: "behavioral response to stimulus" EXACT []
synonym: "behaviour" EXACT []
synonym: "behavioural response to stimulus" EXACT []
xref: Wikipedia:Behavior
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0007611
name: learning or memory
namespace: biological_process
def: "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jic, PMID:8938125]
is_a: GO:0007610 ! behavior
is_a: GO:0050890 ! cognition

[Term]
id: GO:0007612
name: learning
namespace: biological_process
def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
xref: Wikipedia:Learning
is_a: GO:0007611 ! learning or memory

[Term]
id: GO:0007613
name: memory
namespace: biological_process
def: "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [http://cancerweb.ncl.ac.uk/, http://www.onelook.com/, ISBN:0582227089]
xref: Wikipedia:Memory
is_a: GO:0007611 ! learning or memory

[Term]
id: GO:0007614
name: short-term memory
namespace: biological_process
def: "The activities involved in the mental information processing system that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
xref: Wikipedia:Short-term_memory
is_a: GO:0007613 ! memory

[Term]
id: GO:0007615
name: anesthesia-resistant memory
namespace: biological_process
is_a: GO:0007613 ! memory

[Term]
id: GO:0007616
name: long-term memory
namespace: biological_process
def: "The activities involved in the mental information processing system that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
xref: Wikipedia:Long-term_memory
is_a: GO:0007613 ! memory

[Term]
id: GO:0007617
name: mating behavior
namespace: biological_process
def: "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph]
synonym: "mating behaviour" EXACT []
xref: Wikipedia:Mating_behaviour
is_a: GO:0019098 ! reproductive behavior
is_a: GO:0051705 ! behavioral interaction between organisms
relationship: part_of GO:0007618 ! mating

[Term]
id: GO:0007618
name: mating
namespace: biological_process
def: "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [ISBN:0387520546]
is_a: GO:0022414 ! reproductive process
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0007619
name: courtship behavior
namespace: biological_process
def: "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph]
synonym: "courtship behaviour" EXACT []
is_a: GO:0007617 ! mating behavior

[Term]
id: GO:0007620
name: copulation
namespace: biological_process
def: "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0007618 ! mating

[Term]
id: GO:0007621
name: negative regulation of female receptivity
namespace: biological_process
def: "Any process that stops, prevents or reduces the receptiveness of a female to male advances." [GOC:bf, PMID:11092827]
synonym: "down regulation of female receptivity" EXACT []
synonym: "down-regulation of female receptivity" EXACT []
synonym: "downregulation of female receptivity" EXACT []
synonym: "inhibition of female receptivity" NARROW []
is_a: GO:0045924 ! regulation of female receptivity

[Term]
id: GO:0007622
name: rhythmic behavior
namespace: biological_process
def: "The specific actions or reactions of an organism that recur with measured regularity." [GOC:jl]
synonym: "rhythmic behavioral response to stimulus" EXACT []
synonym: "rhythmic behaviour" EXACT []
synonym: "rhythmic behavioural response to stimulus" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0048511 ! rhythmic process

[Term]
id: GO:0007623
name: circadian rhythm
namespace: biological_process
alt_id: GO:0050895
def: "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
subset: gosubset_prok
synonym: "circadian process" EXACT []
synonym: "circadian response" RELATED []
synonym: "response to circadian rhythm" RELATED []
xref: Wikipedia:Circadian_rhythm
is_a: GO:0048511 ! rhythmic process

[Term]
id: GO:0007624
name: ultradian rhythm
namespace: biological_process
def: "The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0048511 ! rhythmic process

[Term]
id: GO:0007625
name: grooming behavior
namespace: biological_process
def: "The specific actions or reactions of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl]
synonym: "grooming behaviour" EXACT []
is_a: GO:0007610 ! behavior

[Term]
id: GO:0007626
name: locomotory behavior
namespace: biological_process
def: "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph]
subset: gosubset_prok
synonym: "behavior via locomotion" EXACT []
synonym: "locomotion in response to stimulus" EXACT []
synonym: "locomotory behavioral response to stimulus" EXACT []
synonym: "locomotory behaviour" EXACT []
synonym: "locomotory behavioural response to stimulus" EXACT []
is_a: GO:0007610 ! behavior

[Term]
id: GO:0007627
name: larval behavior (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics, as seen in insects." [GOC:ai, GOC:jic]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
is_obsolete: true
replaced_by: GO:0030537

[Term]
id: GO:0007628
name: adult walking behavior
namespace: biological_process
def: "The actions or reactions of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jic, ISBN:0198606907]
synonym: "adult walking behaviour" EXACT []
is_a: GO:0008344 ! adult locomotory behavior

[Term]
id: GO:0007629
name: flight behavior
namespace: biological_process
def: "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jic, ISBN:0198606907]
synonym: "flight behaviour" EXACT []
is_a: GO:0008344 ! adult locomotory behavior

[Term]
id: GO:0007630
name: jump response
namespace: biological_process
def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus." [GOC:jic, ISBN:0198606907]
is_a: GO:0008344 ! adult locomotory behavior

[Term]
id: GO:0007631
name: feeding behavior
namespace: biological_process
def: "Behavior associated with the intake of food." [GOC:mah]
comment: See also the biological process term 'behavior ; GO:0007610'.
synonym: "behavioral response to food" EXACT []
synonym: "behavioural response to food" EXACT []
synonym: "drinking" NARROW []
synonym: "eating" NARROW []
synonym: "feeding behaviour" EXACT []
xref: Wikipedia:List_of_feeding_behaviours
is_a: GO:0007610 ! behavior

[Term]
id: GO:0007632
name: visual behavior
namespace: biological_process
def: "The actions or reactions of an organism in response to a visual stimulus." [GOC:jic]
synonym: "behavioral response to visual stimulus" EXACT []
synonym: "behavioural response to visual stimulus" EXACT []
synonym: "visual behaviour" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0009416 ! response to light stimulus
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0007633
name: pattern orientation
namespace: biological_process
def: "The actions or reactions of an individual in response to the orientation of a visual pattern. This is exemplified by some classes of insects which are able to detect and learn the orientation of a set of stripes and subsequently behaviorally discriminate between horizontal, vertical or 45 degree stripes." [GOC:jic, PMID:9933535]
synonym: "behavioral response to pattern orientation" EXACT []
synonym: "behavioural response to pattern orientation" EXACT []
is_a: GO:0007632 ! visual behavior

[Term]
id: GO:0007634
name: optokinetic behavior
namespace: biological_process
def: "The actions or reactions of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus." [GOC:jic, http://www.mercksource.com]
synonym: "optokinetic behaviour" EXACT []
is_a: GO:0007632 ! visual behavior

[Term]
id: GO:0007635
name: chemosensory behavior
namespace: biological_process
def: "Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators]
synonym: "behavioral response to chemical stimulus" EXACT []
synonym: "behavioural response to chemical stimulus" EXACT []
synonym: "chemosensory behaviour" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0007636
name: chemosensory jump behavior
namespace: biological_process
def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance." [GOC:jic]
synonym: "chemosensory jump behaviour" EXACT []
synonym: "jump response to chemical stimulus" EXACT []
is_a: GO:0007630 ! jump response
is_a: GO:0007635 ! chemosensory behavior

[Term]
id: GO:0007637
name: proboscis extension reflex
namespace: biological_process
def: "The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus." [FB:FBrf0044924, GOC:jic, http://fbserver.gen.cam.ac.uk]
synonym: "behavioral response to sugar stimulus, proboscis extension" EXACT []
synonym: "proboscis extension in response to sugar stimulus" EXACT []
is_a: GO:0007635 ! chemosensory behavior
is_a: GO:0051780 ! behavioral response to nutrient
is_a: GO:0060004 ! reflex

[Term]
id: GO:0007638
name: mechanosensory behavior
namespace: biological_process
def: "Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators]
synonym: "behavioral response to mechanical stimulus" EXACT []
synonym: "behavioural response to mechanical stimulus" EXACT []
synonym: "mechanosensory behaviour" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0009612 ! response to mechanical stimulus

[Term]
id: GO:0007639
name: homeostasis of number of meristem cells
namespace: biological_process
def: "Any biological process involved in the maintenance of the equilibrium of cell number within a population of cells in the meristem." [GOC:isa_complete]
is_a: GO:0010075 ! regulation of meristem growth
is_a: GO:0048873 ! homeostasis of number of cells within a tissue

[Term]
id: GO:0008001
name: fibrinogen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it does not describe an activity.
is_obsolete: true
replaced_by: GO:0005577

[Term]
id: GO:0008002
name: lamina lucida
namespace: cellular_component
def: "The electron-lucent layer of the basal lamina adjacent to the basal plasma membrane of the cells that rest on the lamina." [ISBN:0815316194]
xref: Wikipedia:Lamina_lucida
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0005605 ! basal lamina

[Term]
id: GO:0008003
name: lamina densa
namespace: cellular_component
def: "The electron-dense layer of the basal lamina; lies just below the lamina lucida." [ISBN:0815316194]
xref: Wikipedia:Lamina_densa
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0005605 ! basal lamina

[Term]
id: GO:0008004
name: lamina reticularis
namespace: cellular_component
def: "A layer of the basal lamina that contains collagen fibrils and connects the basal lamina to the underlying connective tissue." [ISBN:0815316194]
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0005605 ! basal lamina

[Term]
id: GO:0008008
name: membrane attack complex protein beta2 chain
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0005579

[Term]
id: GO:0008009
name: chemokine activity
namespace: molecular_function
def: "The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation." [http://www.copewithcytokines.de/cope.cgi?key=Cytokines]
comment: See also the molecular function term 'cytokine activity ; GO:0005125'.
is_a: GO:0005125 ! cytokine activity
is_a: GO:0042379 ! chemokine receptor binding

[Term]
id: GO:0008010
name: structural constituent of chitin-based larval cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
synonym: "structural constituent of larval cuticle" BROAD []
is_a: GO:0005214 ! structural constituent of chitin-based cuticle

[Term]
id: GO:0008011
name: structural constituent of pupal chitin-based cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
synonym: "structural constituent of pupal cuticle" BROAD []
is_a: GO:0005214 ! structural constituent of chitin-based cuticle

[Term]
id: GO:0008012
name: structural constituent of adult chitin-based cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]
synonym: "structural constituent of adult cuticle" BROAD []
is_a: GO:0005214 ! structural constituent of chitin-based cuticle

[Term]
id: GO:0008013
name: beta-catenin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the beta subunit of the catenin complex." [GOC:bf]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008014
name: calcium-dependent cell adhesion molecule activity
namespace: molecular_function
alt_id: GO:0001538
def: "OBSOLETE. A calcium-dependent cell adhesion protein (type I membrane protein) that interacts in a homophilic manner in cell-cell interactions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a gene product.
synonym: "cadherin" NARROW []
is_obsolete: true
replaced_by: GO:0005515
replaced_by: GO:0016021
replaced_by: GO:0016339

[Term]
id: GO:0008015
name: blood circulation
namespace: biological_process
alt_id: GO:0070261
def: "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825]
subset: goslim_pir
synonym: "hemolymph circulation" RELATED []
is_a: GO:0003013 ! circulatory system process

[Term]
id: GO:0008016
name: regulation of heart contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process by which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "regulation of cardiac contraction" EXACT []
is_a: GO:0044057 ! regulation of system process
relationship: regulates GO:0060047 ! heart contraction

[Term]
id: GO:0008017
name: microtubule binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc]
synonym: "microtubule severing activity" RELATED []
synonym: "microtubule/chromatin interaction" RELATED []
is_a: GO:0015631 ! tubulin binding

[Term]
id: GO:0008018
name: structural protein of chorion (sensu Drosophila)
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the function is covered by a parent term.
is_obsolete: true
replaced_by: GO:0005213

[Term]
id: GO:0008019
name: macrophage receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because its name is ambiguous, and it was never defined.
is_obsolete: true
consider: GO:0005044
consider: GO:0008329

[Term]
id: GO:0008020
name: G-protein coupled photoreceptor activity
namespace: molecular_function
alt_id: GO:0004975
def: "A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light." [GOC:dph, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "G protein coupled photoreceptor activity" EXACT []
synonym: "G-protein-coupled photoreceptor activity" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity
is_a: GO:0009881 ! photoreceptor activity

[Term]
id: GO:0008021
name: synaptic vesicle
namespace: cellular_component
def: "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and is secreted these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709]
xref: NIF_Subcellular:sao1071221672
xref: Wikipedia:Synaptic_vesicle
is_a: GO:0030136 ! clathrin-coated vesicle
is_a: GO:0044456 ! synapse part

[Term]
id: GO:0008022
name: protein C-terminus binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "C-terminal binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008023
name: transcription elongation factor complex
namespace: cellular_component
def: "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0008024
name: positive transcription elongation factor complex b
namespace: cellular_component
def: "A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains cyclin T and a cyclin-dependent protein kinase catalytic subunit." [PMID:10766736, PMID:16721054, PMID:17079683, PMID:19328067, PMID:7759473]
comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'.
synonym: "P-TEFb" EXACT [PMID:7759473]
is_a: GO:0008023 ! transcription elongation factor complex
is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex

[Term]
id: GO:0008025
name: diazepam binding inhibitor activity
namespace: molecular_function
def: "OBSOLETE. The diazepam binding inhibitor is a 10kDa 86-residue polypeptide that acts as an endogenous ligand for a mitochondrial receptor (formerly regarded as a peripheral benzodiazepine binding site) in steroidogenic cells and regulates stimulation of steroidogenesis by tropic hormones. It also binds to the GABA-A receptor and modulates glucose-dependent insulin secretion and synthesis of acyl-CoA esters." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11883709]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "DBI" EXACT []
synonym: "diazepam-binding inhibitor activity" EXACT []
is_obsolete: true
consider: GO:0004857
consider: GO:0030156
consider: GO:0050796
consider: GO:0050809
consider: GO:0050810
consider: GO:0050811
consider: GO:0050812

[Term]
id: GO:0008026
name: ATP-dependent helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
is_a: GO:0042623 ! ATPase activity, coupled
is_a: GO:0070035 ! purine NTP-dependent helicase activity

[Term]
id: GO:0008028
name: monocarboxylic acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0008505
def: "Catalysis of the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai]
subset: gosubset_prok
synonym: "monocarboxylate carrier" NARROW []
synonym: "prostaglandin/thromboxane transporter activity" NARROW []
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0008029
name: pentraxin receptor activity
namespace: molecular_function
def: "Combining with a pentraxin to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP).
synonym: "pentaxin receptor" EXACT []
is_a: GO:0001847 ! opsonin receptor activity
is_a: GO:0001864 ! pentraxin binding

[Term]
id: GO:0008030
name: neuronal pentraxin receptor activity
namespace: molecular_function
synonym: "neuronal pentaxin receptor" EXACT []
is_a: GO:0008029 ! pentraxin receptor activity

[Term]
id: GO:0008031
name: eclosion hormone activity
namespace: molecular_function
def: "The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0005184 ! neuropeptide hormone activity

[Term]
id: GO:0008033
name: tRNA processing
namespace: biological_process
def: "The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506]
subset: gosubset_prok
synonym: "tRNA maturation" EXACT [GOC:vw]
is_a: GO:0006399 ! tRNA metabolic process
is_a: GO:0034470 ! ncRNA processing

[Term]
id: GO:0008034
name: lipoprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008035
name: high-density lipoprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with high-density lipoprotein: one of the classes of lipoproteins found in blood plasma in many animals (data normally relate to humans)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0008034 ! lipoprotein binding

[Term]
id: GO:0008036
name: diuretic hormone receptor activity
namespace: molecular_function
def: "Combining with a diuretic hormone to initiate a change in cell activity." [GOC:ai]
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0008037
name: cell recognition
namespace: biological_process
def: "The process by which a cell in a multicellular organism interprets its surroundings." [GOC:go_curators]
subset: goslim_generic
subset: goslim_pir
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0032501 ! multicellular organismal process

[Term]
id: GO:0008038
name: neuron recognition
namespace: biological_process
def: "The process by which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators]
synonym: "neuronal cell recognition" EXACT []
is_a: GO:0008037 ! cell recognition
relationship: part_of GO:0048666 ! neuron development

[Term]
id: GO:0008039
name: synaptic target recognition
namespace: biological_process
def: "The process by which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437]
synonym: "neuronal targeting" EXACT []
is_a: GO:0008038 ! neuron recognition

[Term]
id: GO:0008041
name: storage protein of fat body (sensu Insecta)
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it describes a cellular location rather than a function.
is_obsolete: true
replaced_by: GO:0045735

[Term]
id: GO:0008042
name: iron-sulfur electron transfer carrier
namespace: molecular_function
def: "OBSOLETE. An iron-sulfur protein that serves as an electron acceptor and electron donor in an electron transport system." [GOC:kd]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "ferredoxin" NARROW []
synonym: "iron-sulphur electron transfer carrier" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0008043
name: intracellular ferritin complex
namespace: cellular_component
def: "A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains." [GOC:jl, GOC:mah, PMID:19154717]
is_a: GO:0044424 ! intracellular part
is_a: GO:0070288 ! ferritin complex

[Term]
id: GO:0008044
name: adult behavior (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. Behavior in a fully developed and mature organism, as seen in insects." [GOC:bf, GOC:jic]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
is_obsolete: true
replaced_by: GO:0030534

[Term]
id: GO:0008045
name: motor axon guidance
namespace: biological_process
def: "The process by which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437]
synonym: "motor axon pathfinding" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0008046
name: axon guidance receptor activity
namespace: molecular_function
def: "Combining with an extracellular messenger that results in a change in cellular activity involved in axon guidance." [GOC:dph, GOC:tb]
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0008047
name: enzyme activator activity
namespace: molecular_function
def: "Increases the activity of an enzyme." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0008048
name: calcium sensitive guanylate cyclase activator activity
namespace: molecular_function
is_a: GO:0030250 ! guanylate cyclase activator activity

[Term]
id: GO:0008049
name: male courtship behavior
namespace: biological_process
alt_id: GO:0016542
def: "The actions or reactions of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
synonym: "male courtship behaviour" EXACT []
is_a: GO:0060179 ! male mating behavior
relationship: part_of GO:0007619 ! courtship behavior

[Term]
id: GO:0008050
name: female courtship behavior
namespace: biological_process
def: "The actions or reactions of a female, for the purpose of attracting a sexual partner." [GOC:bf]
synonym: "female courtship behaviour" EXACT []
is_a: GO:0060180 ! female mating behavior
relationship: part_of GO:0007619 ! courtship behavior

[Term]
id: GO:0008051
name: farnesyl-diphosphate farnesyl transferase complex
namespace: cellular_component
def: "OBSOLETE. A complex that possesses farnesyl-diphosphate farnesyl transferase activity." [GOC:mah]
comment: This term was made obsolete because there is no evidence that this enzyme ever exists as anything other than a monomer.
is_obsolete: true
consider: GO:0004310

[Term]
id: GO:0008052
name: sensory organ boundary specification
namespace: biological_process
def: "The process by which boundaries between a sensory organ and the surrounding tissue are established and maintained." [GO_REF:0000021, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "sense organ boundary specification" EXACT [GOC:dph]
is_a: GO:0010160 ! formation of organ boundary
relationship: part_of GO:0007423 ! sensory organ development

[Term]
id: GO:0008053
name: mitochondrial fusion
namespace: biological_process
def: "Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192]
is_a: GO:0006944 ! cellular membrane fusion
is_a: GO:0048284 ! organelle fusion
is_a: GO:0070584 ! mitochondrion morphogenesis

[Term]
id: GO:0008054
name: cyclin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions." [GOC:mah, http://cancerweb.ncl.ac.uk/]
synonym: "cyclin breakdown" EXACT []
synonym: "cyclin catabolism" EXACT []
synonym: "cyclin degradation" EXACT []
synonym: "degradation of cyclin" EXACT []
is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process

[Term]
id: GO:0008055
name: ocellus pigment biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, http://cancerweb.ncl.ac.uk/]
synonym: "ocellus pigment anabolism" EXACT []
synonym: "ocellus pigment biosynthesis" EXACT []
synonym: "ocellus pigment formation" EXACT []
synonym: "ocellus pigment synthesis" EXACT []
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0046158 ! ocellus pigment metabolic process

[Term]
id: GO:0008056
name: ocellus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035214 ! eye-antennal disc development

[Term]
id: GO:0008057
name: eye pigment granule organization
namespace: biological_process
alt_id: GO:0008059
alt_id: GO:0045318
alt_id: GO:0048751
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295]
synonym: "eye pigment granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0048753 ! pigment granule organization

[Term]
id: GO:0008058
name: ocellus pigment granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm]
synonym: "ocellus pigment granule organisation" EXACT [GOC:curators]
synonym: "ocellus pigment granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0048753 ! pigment granule organization

[Term]
id: GO:0008060
name: ARF GTPase activator activity
namespace: molecular_function
def: "Increases the rate of GTP hydrolysis by the GTPase ARF." [GOC:mah]
synonym: "ARF GAP activity" EXACT [GOC:pg]
is_a: GO:0005083 ! small GTPase regulator activity
is_a: GO:0005096 ! GTPase activator activity

[Term]
id: GO:0008061
name: chitin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0008062
name: eclosion rhythm
namespace: biological_process
def: "The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043]
is_a: GO:0048512 ! circadian behavior
relationship: part_of GO:0007562 ! eclosion

[Term]
id: GO:0008063
name: Toll signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to the Toll receptor on the surface of the target cell." [GOC:go_curators, PMID:11135568, PMID:19126860]
synonym: "Tl signaling pathway" EXACT []
synonym: "Tl signalling pathway" EXACT []
synonym: "Toll signalling pathway" EXACT []
xref: Reactome:166016 "Toll Like Receptor 4 (TLR4) Cascade"
xref: Reactome:448845 "Toll Like Receptor 4 (TLR4) Cascade"
xref: Reactome:469961 "Toll Like Receptor 4 (TLR4) Cascade"
xref: Reactome:488101 "Toll Like Receptor 4 (TLR4) Cascade"
xref: Reactome:507927 "Toll Like Receptor 4 (TLR4) Cascade"
is_a: GO:0007166 ! cell surface receptor linked signaling pathway
is_a: GO:0023034 ! intracellular signaling pathway

[Term]
id: GO:0008064
name: regulation of actin polymerization or depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]
is_a: GO:0030832 ! regulation of actin filament length
relationship: regulates GO:0008154 ! actin polymerization or depolymerization

[Term]
id: GO:0008065
name: establishment of blood-nerve barrier
namespace: biological_process
def: "The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier." [GOC:dgh]
synonym: "establishment of blood/nerve barrier" EXACT []
is_a: GO:0001885 ! endothelial cell development
relationship: part_of GO:0007422 ! peripheral nervous system development

[Term]
id: GO:0008066
name: glutamate receptor activity
namespace: molecular_function
def: "Combining with glutamate to initiate a change in cell activity." [GOC:ai]
subset: gosubset_prok
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0008067
name: metabotropic glutamate, GABA-B-like receptor activity
namespace: molecular_function
alt_id: GO:0001643
alt_id: GO:0001645
def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1285]
comment: This term was made obsolete because it represents a gene product and is named based on protein features.
synonym: "class C G protein coupled receptor" BROAD []
synonym: "class C G-protein coupled receptor" BROAD []
synonym: "class C GPCR" BROAD []
synonym: "class C orphan receptor activity" EXACT []
is_obsolete: true

[Term]
id: GO:0008068
name: extracellular-glutamate-gated chloride channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'.
is_a: GO:0005234 ! extracellular-glutamate-gated ion channel activity
is_a: GO:0005254 ! chloride channel activity

[Term]
id: GO:0008069
name: dorsal/ventral axis specification, ovarian follicular epithelium
namespace: biological_process
def: "Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb]
synonym: "dorsal-ventral axis specification, ovarian follicular epithelium" EXACT [GOC:mah]
synonym: "dorsal/ventral axis determination, follicular epithelium" RELATED []
synonym: "dorsal/ventral axis determination, ovarian follicular epithelium" EXACT [GOC:dph, GOC:tb]
synonym: "dorsoventral axis specification, ovarian follicular epithelium" EXACT [GOC:mah]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0009950 ! dorsal/ventral axis specification
is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0030707 ! ovarian follicle cell development

[Term]
id: GO:0008070
name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded
namespace: biological_process
def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by cells of the germ line." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, germ-line encoded" EXACT [GOC:mah]
synonym: "maternal determination of dorsoventral axis, ovarian follicular epithelium, germ-line encoded" EXACT [GOC:mah]
is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium

[Term]
id: GO:0008071
name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded
namespace: biological_process
def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by somatic cells. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, soma encoded" EXACT [GOC:mah]
synonym: "maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded" BROAD []
synonym: "maternal determination of dorsoventral axis, ovarian follicular epithelium, soma encoded" EXACT [GOC:mah]
is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium

[Term]
id: GO:0008073
name: ornithine decarboxylase inhibitor activity
namespace: molecular_function
def: "The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase." [GOC:jl]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0042979 ! ornithine decarboxylase regulator activity

[Term]
id: GO:0008074
name: guanylate cyclase complex, soluble
namespace: cellular_component
def: "Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah]
comment: See also the molecular function term 'guanylate cyclase activity ; GO:0004383'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0008075
name: receptor guanylate cyclase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
consider: GO:0004383
consider: GO:0004872

[Term]
id: GO:0008076
name: voltage-gated potassium channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah]
subset: gosubset_prok
synonym: "voltage gated potassium channel complex" EXACT []
synonym: "voltage-dependent potassium channel complex" EXACT []
synonym: "voltage-sensitive potassium channel complex" EXACT []
xref: NIF_Subcellular:sao371494298
is_a: GO:0034705 ! potassium channel complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0008077
name: Hsp70/Hsp90 organizing protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:rb]
comment: This term was made obsolete because it represents a specific gene product rather than a molecular function.
synonym: "Hsp70/Hsp90 organising protein activity" EXACT []
is_obsolete: true
consider: GO:0030674

[Term]
id: GO:0008078
name: mesodermal cell migration
namespace: biological_process
def: "The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb]
synonym: "mesoderm cell migration" EXACT []
is_a: GO:0042074 ! cell migration involved in gastrulation
relationship: part_of GO:0007509 ! mesoderm migration

[Term]
id: GO:0008079
name: translation termination factor activity
namespace: molecular_function
def: "Functions in the termination of translation." [GOC:ma]
subset: gosubset_prok
is_a: GO:0008135 ! translation factor activity, nucleic acid binding

[Term]
id: GO:0008080
name: N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0016407 ! acetyltransferase activity
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0008081
name: phosphoric diester hydrolase activity
namespace: molecular_function
alt_id: GO:0016792
def: "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "endonuclease VIII activity" RELATED []
synonym: "phosphodiesterase" NARROW []
xref: EC:3.1.4
is_a: GO:0042578 ! phosphoric ester hydrolase activity

[Term]
id: GO:0008083
name: growth factor activity
namespace: molecular_function
def: "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0008084
name: imaginal disc growth factor activity
namespace: molecular_function
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0008085
name: phototransduction, visible light, light adaptation
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because the term name is ambiguous.
is_obsolete: true
consider: GO:0007602

[Term]
id: GO:0008086
name: light-activated voltage-gated calcium channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light." [GOC:mtg_transport]
synonym: "light-activated voltage gated calcium channel activity" EXACT []
synonym: "light-activated voltage-dependent calcium channel activity" EXACT []
is_a: GO:0005245 ! voltage-gated calcium channel activity
is_a: GO:0010461 ! light-activated channel activity

[Term]
id: GO:0008087
name: light-activated voltage-gated calcium channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus." [GOC:mah, PMID:9223679]
synonym: "light-activated voltage gated calcium channel complex" EXACT []
synonym: "light-activated voltage-dependent calcium channel complex" EXACT []
synonym: "light-activated voltage-sensitive calcium channel complex" EXACT []
is_a: GO:0005891 ! voltage-gated calcium channel complex

[Term]
id: GO:0008088
name: axon cargo transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194]
synonym: "axonal transport" EXACT []
xref: Wikipedia:Axoplasmic_transport
is_a: GO:0010970 ! microtubule-based transport

[Term]
id: GO:0008089
name: anterograde axon cargo transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194]
synonym: "anterograde axonal transport" EXACT []
is_a: GO:0008088 ! axon cargo transport

[Term]
id: GO:0008090
name: retrograde axon cargo transport
namespace: biological_process
def: "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194]
synonym: "retrograde axonal transport" RELATED []
is_a: GO:0008088 ! axon cargo transport

[Term]
id: GO:0008091
name: spectrin
namespace: cellular_component
def: "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [http://cancerweb.ncl.ac.uk/]
xref: NIF_Subcellular:sao536287099
xref: Wikipedia:Spectrin
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0008092
name: cytoskeletal protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah]
subset: goslim_generic
subset: gosubset_prok
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008093
name: cytoskeletal adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a cytoskeletal molecule and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07]
is_a: GO:0008092 ! cytoskeletal protein binding
is_a: GO:0060090 ! molecular adaptor activity

[Term]
id: GO:0008094
name: DNA-dependent ATPase activity
namespace: molecular_function
alt_id: GO:0004011
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction." [EC:3.6.1.3, GOC:jl]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "adenosinetriphosphatase (DNA-dependent)" EXACT []
synonym: "DNA dependent ATPase activity" EXACT []
synonym: "DNA-dependent adenosinetriphosphatase activity" EXACT []
is_a: GO:0042623 ! ATPase activity, coupled

[Term]
id: GO:0008095
name: inositol-1,4,5-trisphosphate receptor activity
namespace: molecular_function
def: "Combining with inositol-1,4,5-trisphosphate to initiate a change in cell activity." [GOC:ai]
synonym: "IP3 receptor activity" EXACT []
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0008096
name: juvenile hormone epoxide hydrolase activity
namespace: molecular_function
xref: EC:3.3.2.-
is_a: GO:0004301 ! epoxide hydrolase activity

[Term]
id: GO:0008097
name: 5S rRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382]
subset: gosubset_prok
is_a: GO:0019843 ! rRNA binding

[Term]
id: GO:0008098
name: 5S rRNA primary transcript binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the unprocessed 5S ribosomal RNA transcript." [GOC:jl]
is_a: GO:0008097 ! 5S rRNA binding

[Term]
id: GO:0008100
name: lipophorin
namespace: molecular_function
def: "OBSOLETE. Any member of the major class of lipid-transporting proteins found in the hemolymph of insects." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
replaced_by: GO:0005319

[Term]
id: GO:0008101
name: decapentaplegic receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a decapentaplegic receptor binding to one of its physiological ligands." [GOC:ai]
synonym: "decapentaplegic receptor signalling pathway" EXACT []
synonym: "dpp receptor signaling pathway" EXACT []
synonym: "dpp receptor signalling pathway" EXACT []
is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0008103
name: oocyte microtubule cytoskeleton polarization
namespace: biological_process
alt_id: GO:0048129
def: "Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042]
is_a: GO:0007017 ! microtubule-based process
relationship: part_of GO:0007309 ! oocyte axis specification
relationship: part_of GO:0016325 ! oocyte microtubule cytoskeleton organization

[Term]
id: GO:0008104
name: protein localization
namespace: biological_process
def: "Any process by which a protein is transported to, or maintained in, a specific location." [GOC:ai]
subset: gosubset_prok
synonym: "establishment and maintenance of protein localization" EXACT []
is_a: GO:0033036 ! macromolecule localization

[Term]
id: GO:0008105
name: asymmetric protein localization
namespace: biological_process
def: "Any process by which a protein is transported to, or maintained in, a specific asymmetric distribution." [GOC:ma]
subset: gosubset_prok
synonym: "establishment and maintenance of asymmetric protein localization" EXACT []
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0008106
name: alcohol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [EC:1.1.1.2]
subset: gosubset_prok
synonym: "aldehyde reductase (NADPH) activity" EXACT [EC:1.1.1.2]
synonym: "aldehyde reductase (NADPH2)" EXACT []
synonym: "NADP-aldehyde reductase activity" EXACT []
xref: EC:1.1.1.2
xref: MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN
is_a: GO:0004033 ! aldo-keto reductase activity

[Term]
id: GO:0008107
name: galactoside 2-alpha-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R." [EC:2.4.1.69]
subset: gosubset_prok
synonym: "alpha(1,2)-L-fucosyltransferase activity" EXACT []
synonym: "alpha-(1->2)-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "alpha-2-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "alpha-2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "beta-galactoside alpha-1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "blood group H alpha-2-fucosyltransferase activity" NARROW [EC:2.4.1.69]
synonym: "blood-group substance H-dependent fucosyltransferase activity" NARROW [EC:2.4.1.69]
synonym: "galactoside 2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "GDP fucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "GDP-L-fucose:lactose fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "guanosine diphospho-L-fucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-galactoside 2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosyl-glucosylceramide alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "guanosine diphosphofucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "H-gene-encoded beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69]
synonym: "H-gene-encoded beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69]
synonym: "secretor-type beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69]
synonym: "secretor-type beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69]
xref: EC:2.4.1.69
xref: MetaCyc:GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN
is_a: GO:0031127 ! alpha(1,2)-fucosyltransferase activity

[Term]
id: GO:0008108
name: UDP-glucose:hexose-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose." [EC:2.7.7.12]
subset: gosubset_prok
synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.12]
synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.12]
synonym: "hexose 1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.12]
synonym: "hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12]
synonym: "UDP-glucose-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12]
synonym: "UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12]
synonym: "UDPglucose-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12]
synonym: "UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12]
synonym: "uridyl transferase activity" BROAD [EC:2.7.7.12]
synonym: "uridyltransferase activity" EXACT [EC:2.7.7.12]
synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.12]
xref: EC:2.7.7.12
xref: MetaCyc:GALACTURIDYLYLTRANS-RXN
xref: Reactome:22869 "UDP-glucose:hexose-1-phosphate uridylyltransferase activity"
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0008109
name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.150]
synonym: "galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150]
synonym: "N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150]
synonym: "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.150]
synonym: "UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.150]
synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.150]
xref: EC:2.4.1.150
xref: MetaCyc:2.4.1.150-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0008110
name: L-histidine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-histidine + 2-oxoglutarate = imidazol-5-yl-pyruvate + L-glutamate." [EC:2.6.1.38]
synonym: "histidine aminotransferase activity" BROAD []
synonym: "histidine transaminase activity" BROAD [EC:2.6.1.38]
synonym: "histidine-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.38]
xref: EC:2.6.1.38
xref: MetaCyc:HISTTRANSAM-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0008111
name: alpha-methylacyl-CoA racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA." [EC:5.1.99.4]
subset: gosubset_prok
synonym: "2-methylacyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.4]
xref: EC:5.1.99.4
xref: MetaCyc:5.1.99.4-RXN
xref: Reactome:22891 "alpha-methylacyl-CoA racemase activity"
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0008112
name: nicotinamide N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide." [EC:2.1.1.1]
subset: gosubset_prok
synonym: "nicotinamide methyltransferase activity" EXACT [EC:2.1.1.1]
synonym: "S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity" EXACT [EC:2.1.1.1]
xref: EC:2.1.1.1
xref: MetaCyc:NICOTINAMIDE-N-METHYLTRANSFERASE-RXN
xref: Reactome:22892 "nicotinamide N-methyltransferase activity"
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008113
name: peptide-methionine-(S)-S-oxide reductase activity
namespace: molecular_function
alt_id: GO:0033742
def: "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin." [EC:1.8.4.11, PMID:11169920]
subset: gosubset_prok
synonym: "methionine S-oxide reductase (S-form oxidizing) activity" EXACT [EC:1.8.4.11]
synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.11]
synonym: "methionine sulfoxide (protein) reductase activity" EXACT []
synonym: "methionine sulfoxide reductase A activity" EXACT [EC:1.8.4.11]
synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.11]
synonym: "methionine sulphoxide reductase A activity" EXACT [EC:1.8.4.11]
synonym: "MsrA" RELATED [EC:1.8.4.11]
synonym: "peptide Met(O) reductase activity" EXACT [EC:1.8.4.11]
synonym: "peptide methionine sulfoxide reductase activity" EXACT [EC:1.8.4.11]
synonym: "peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity" EXACT [EC:1.8.4.11]
synonym: "protein-methionine-S-oxide reductase activity" EXACT [EC:1.8.4.11]
xref: EC:1.8.4.11
xref: MetaCyc:RXN-8668
xref: MetaCyc:RXN-8669
is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0008114
name: phosphogluconate 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH." [EC:1.1.1.43]
synonym: "2-keto-6-phosphogluconate reductase activity" EXACT [EC:1.1.1.43]
synonym: "6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.43]
synonym: "6-phosphogluconate 2-dehydrogenase activity" EXACT []
synonym: "6-phosphogluconate dehydrogenase (NAD)" EXACT [EC:1.1.1.43]
synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.43]
synonym: "gluconate 6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.43]
synonym: "phosphogluconate dehydrogenase activity" EXACT [EC:1.1.1.43]
xref: EC:1.1.1.43
xref: MetaCyc:1.1.1.43-RXN
xref: Reactome:22895 "phosphogluconate 2-dehydrogenase activity"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008115
name: sarcosine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: sarcosine + H2O + O2 = glycine + formaldehyde + H2O2." [EC:1.5.3.1]
subset: gosubset_prok
synonym: "sarcosine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.1]
xref: EC:1.5.3.1
xref: MetaCyc:SARCOX-RXN
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0008116
name: prostaglandin-I synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate." [EC:5.3.99.4]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase activity" EXACT [EC:5.3.99.4]
synonym: "cytochrome P450 CYP8A1" NARROW []
synonym: "PGI(2) synthase activity" EXACT [EC:5.3.99.4]
synonym: "PGI(2) synthetase activity" EXACT [EC:5.3.99.4]
synonym: "PGI2 synthase activity" EXACT [EC:5.3.99.4]
synonym: "PGI2 synthetase activity" EXACT [EC:5.3.99.4]
synonym: "prostacyclin synthase activity" EXACT [EC:5.3.99.4]
synonym: "prostacycline synthetase activity" EXACT [EC:5.3.99.4]
synonym: "prostagladin I2 synthetase activity" EXACT [EC:5.3.99.4]
xref: EC:5.3.99.4
xref: MetaCyc:PROSTAGLANDIN-I-SYNTHASE-RXN
xref: Reactome:22900 "prostaglandin-I synthase activity"
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0008117
name: sphinganine-1-phosphate aldolase activity
namespace: molecular_function
alt_id: GO:0016001
def: "Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde." [EC:4.1.2.27]
subset: gosubset_prok
synonym: "dihydrosphingosine 1-phosphate aldolase activity" EXACT [EC:4.1.2.27]
synonym: "sphinganine-1-phosphate alkanal-lyase activity" EXACT [EC:4.1.2.27]
synonym: "sphinganine-1-phosphate lyase activity" EXACT [EC:4.1.2.27]
synonym: "sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)" EXACT [EC:4.1.2.27]
synonym: "sphinganine-1-phosphate palmitaldehyde-lyase activity" EXACT [EC:4.1.2.27]
synonym: "sphingosine-1-phosphate aldolase activity" EXACT [EC:4.1.2.27]
synonym: "sphingosine-1-phosphate lyase activity" EXACT [EC:4.1.2.27]
xref: EC:4.1.2.27
xref: MetaCyc:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008118
name: N-acetyllactosaminide alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein." [EC:2.4.99.6]
synonym: "alpha2->3 sialyltransferase activity" EXACT [EC:2.4.99.6]
synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.6]
synonym: "cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity" EXACT [EC:2.4.99.6]
synonym: "SiaT" RELATED [EC:2.4.99.6]
xref: EC:2.4.99.6
xref: MetaCyc:2.4.99.6-RXN
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0008119
name: thiopurine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether." [EC:2.1.1.67]
subset: gosubset_prok
synonym: "6-thiopurine transmethylase activity" EXACT [EC:2.1.1.67]
synonym: "mercaptopurine methyltransferase activity" EXACT [EC:2.1.1.67]
synonym: "S-adenosyl-L-methionine:thiopurine S-methyltransferase activity" EXACT [EC:2.1.1.67]
synonym: "thiopurine methyltransferase activity" EXACT [EC:2.1.1.67]
synonym: "TPMT" RELATED [EC:2.1.1.67]
xref: EC:2.1.1.67
xref: MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN
xref: Reactome:22905 "thiopurine S-methyltransferase activity"
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008120
name: ceramide glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine." [EC:2.4.1.80]
subset: gosubset_prok
synonym: "ceramide:UDP-glucose glucosyltransferase activity" EXACT [EC:2.4.1.80]
synonym: "ceramide:UDPGlc glucosyltransferase activity" EXACT [EC:2.4.1.80]
synonym: "glucosylceramide synthase activity" EXACT [EC:2.4.1.80]
synonym: "UDP-glucose-ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80]
synonym: "UDP-glucose:ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80]
synonym: "UDP-glucose:N-acylsphingosine D-glucosyltransferase activity" EXACT [EC:2.4.1.80]
synonym: "UDPglucose:N-acylsphingosine D-glucosyltransferase activity" EXACT [EC:2.4.1.80]
synonym: "uridine diphosphoglucose-ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80]
xref: EC:2.4.1.80
xref: MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0008121
name: ubiquinol-cytochrome-c reductase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684]
subset: gosubset_prok
synonym: "coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2]
synonym: "coenzyme QH2-cytochrome c reductase activity" EXACT [EC:1.10.2.2]
synonym: "complex III (mitochondrial electron transport) activity" NARROW [EC:1.10.2.2]
synonym: "CoQH2-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "cytochrome bc1 complex" RELATED []
synonym: "dihydrocoenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2]
synonym: "mitochondrial electron transport complex III" RELATED [EC:1.10.2.2]
synonym: "QH2:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "reduced coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2]
synonym: "reduced ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "reduced ubiquinone-cytochrome c reductase, complex III (mitochondrial electron transport)" RELATED [EC:1.10.2.2]
synonym: "ubihydroquinol:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "ubiquinol-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "ubiquinol-cytochrome c-2 oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "ubiquinol-cytochrome c1 oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "ubiquinol-cytochrome c2 reductase activity" EXACT [EC:1.10.2.2]
synonym: "ubiquinol:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "ubiquinone--cytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "ubiquinone-cytochrome b-c1 oxidoreductase activity" EXACT []
synonym: "ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2]
synonym: "ubiquinone-cytochrome c reductase activity" EXACT [EC:1.10.2.2]
xref: EC:1.10.2.2
xref: MetaCyc:1.10.2.2-RXN
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0016681 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor

[Term]
id: GO:0008123
name: cholesterol 7-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O." [EC:1.14.13.17]
synonym: "cholesterol 7-alpha-hydroxylase activity" EXACT []
synonym: "cholesterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.17]
synonym: "cholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.17]
synonym: "cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.17]
synonym: "cytochrome P450 CYP7A1" NARROW []
xref: EC:1.14.13.17
xref: MetaCyc:CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN
xref: Reactome:22932 "cholesterol 7-alpha-monooxygenase activity"
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0008124
name: 4-alpha-hydroxytetrahydrobiopterin dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4-alpha-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O." [EC:4.2.1.96]
subset: gosubset_prok
synonym: "(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]" RELATED [EC:4.2.1.96]
synonym: "4-alpha-hydroxy-tetrahydropterin dehydratase activity" EXACT [EC:4.2.1.96]
synonym: "4a-hydroxytetrahydrobiopterin dehydratase activity" EXACT []
synonym: "4a-hydroxytetrahydrobiopterin hydro-lyase activity" EXACT [EC:4.2.1.96]
synonym: "4alpha-hydroxy-tetrahydropterin dehydratase activity" EXACT [EC:4.2.1.96]
synonym: "pterin-4-alpha-carbinolamine dehydratase activity" EXACT []
synonym: "pterin-4a-carbinolamine dehydratase activity" EXACT []
synonym: "pterin-4alpha-carbinolamine dehydratase activity" EXACT [EC:4.2.1.96]
synonym: "tetrahydrobiopterin dehydratase activity" EXACT [EC:4.2.1.96]
xref: EC:4.2.1.96
xref: MetaCyc:RXN-7908
xref: Reactome:22934 "4-alpha-hydroxytetrahydrobiopterin dehydratase activity"
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008125
name: pancreatic elastase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa." [EC:3.4.21.36]
comment: This term was made obsolete because it represents a gene product.
synonym: "elaszym" RELATED [EC:3.4.21.36]
synonym: "pancreatopeptidase E activity" EXACT [EC:3.4.21.36]
synonym: "serine elastase" BROAD [EC:3.4.21.36]
xref: EC:3.4.21.36
xref: MetaCyc:3.4.21.36-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008126
name: acetylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate." [EC:3.1.1.6]
subset: gosubset_prok
synonym: "acetic ester hydrolase activity" EXACT [EC:3.1.1.6]
synonym: "acetic-ester acetylhydrolase activity" EXACT [EC:3.1.1.6]
synonym: "C-esterase (in animal tissues)" NARROW [EC:3.1.1.6]
synonym: "chloroesterase" NARROW [EC:3.1.1.6]
synonym: "citrus acetylesterase" NARROW [EC:3.1.1.6]
synonym: "p-nitrophenyl acetate esterase" NARROW [EC:3.1.1.6]
xref: EC:3.1.1.6
xref: MetaCyc:ACETYLESTERASE-RXN
xref: UM-BBD_enzymeID:e0052
is_a: GO:0034338 ! short-chain carboxylesterase activity

[Term]
id: GO:0008127
name: quercetin 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: quercetin + O2 = 2-protocatechuoylphloroglucinolcarboxylate + CO." [EC:1.13.11.24]
synonym: "flavonol 2,4-oxygenase activity" EXACT [EC:1.13.11.24]
synonym: "quercetin:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.24]
synonym: "quercetinase activity" EXACT [EC:1.13.11.24]
xref: EC:1.13.11.24
xref: MetaCyc:QUERCETIN-23-DIOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0559
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0008129
name: actinidain activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'." [EC:3.4.22.14]
comment: This term was made obsolete because it represents a gene product.
synonym: "actinidia anionic protease activity" NARROW [EC:3.4.22.14]
synonym: "actinidin activity" EXACT [EC:3.4.22.14]
synonym: "proteinase A2 of actinidia chinensis" RELATED [EC:3.4.22.14]
xref: EC:3.4.22.14
xref: MetaCyc:3.4.22.14-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0008130
name: neutrophil collagenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I." [EC:3.4.24.34]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 8 activity" EXACT [EC:3.4.24.34]
synonym: "MMP-8" EXACT []
synonym: "PMNL collagenase activity" EXACT [EC:3.4.24.34]
xref: EC:3.4.24.34
xref: MetaCyc:3.4.24.34-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008131
name: amine oxidase activity
namespace: molecular_function
alt_id: GO:0004041
alt_id: GO:0008122
def: "Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2." [EC:1.4.3.21, EC:1.4.3.22, EC:1.4.3.4]
subset: gosubset_prok
synonym: "adrenalin oxidase" NARROW [EC:1.4.3.4]
synonym: "adrenaline oxidase activity" NARROW [EC:1.4.3.4]
synonym: "amine oxidase (copper-containing) activity" NARROW []
synonym: "amine oxidase (flavin-containing) activity" NARROW []
synonym: "amine oxidase (pyridoxal containing)" NARROW [EC:1.4.3.4]
synonym: "amine oxygen oxidoreductase activity" EXACT [EC:1.4.3.4]
synonym: "amine:oxygen oxidoreductase (deaminating) (flavin-containing)" NARROW [EC:1.4.3.4]
synonym: "benzylamine oxidase" NARROW [EC:1.4.3.4]
synonym: "Cu-amine oxidase activity" RELATED [EC:1.4.3.21]
synonym: "DAO activity" NARROW [EC:1.4.3.4]
synonym: "diamine oxidase activity" RELATED [EC:1.4.3.22]
synonym: "diamino oxhydrase activity" NARROW [EC:1.4.3.4]
synonym: "epinephrine oxidase" NARROW [EC:1.4.3.4]
synonym: "histaminase activity" NARROW [EC:1.4.3.22]
synonym: "histamine deaminase" NARROW [EC:1.4.3.21]
synonym: "histamine oxidase" NARROW [EC:1.4.3.21]
synonym: "MAO" RELATED [EC:1.4.3.4]
synonym: "monoamine oxidase activity" NARROW [EC:1.4.3.4]
synonym: "monoamine:O2 oxidoreductase (deaminating)" NARROW [EC:1.4.3.4]
synonym: "semicarbazide-sensitive amine oxidase" NARROW [EC:1.4.3.22]
synonym: "serotonin deaminase" NARROW [EC:1.4.3.4]
synonym: "spermidine oxidase" NARROW [EC:1.4.3.4]
synonym: "spermine oxidase" NARROW [EC:1.4.3.4]
synonym: "SSAO" RELATED [EC:1.4.3.4]
synonym: "tyraminase activity" NARROW [EC:1.4.3.4]
synonym: "tyramine oxidase activity" NARROW [EC:1.4.3.4]
xref: EC:1.4.3.21
xref: EC:1.4.3.22
xref: EC:1.4.3.4
xref: MetaCyc:AMINEOXID-RXN
xref: Reactome:7141 "amine oxidase activity"
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0008132
name: pancreatic elastase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin." [EC:3.4.21.36, EC:3.4.21.71]
comment: This term was made obsolete because it represents a gene product.
xref: EC:3.4.21.-
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008133
name: collagenase activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
xref: EC:3.4.24.-
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008134
name: transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "TF binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008135
name: translation factor activity, nucleic acid binding
namespace: molecular_function
def: "Functions during translation by binding nucleic acids during polypeptide synthesis at the ribosome." [GOC:ai]
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0008137
name: NADH dehydrogenase (ubiquinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3]
subset: gosubset_prok
synonym: "coenzyme Q reductase activity" EXACT [EC:1.6.5.3]
synonym: "complex 1 dehydrogenase activity" RELATED [EC:1.6.5.3]
synonym: "complex I (electron transport chain) activity" RELATED [EC:1.6.5.3]
synonym: "complex I (mitochondrial electron transport) activity" RELATED [EC:1.6.5.3]
synonym: "complex I (NADH:Q1 oxidoreductase) activity" RELATED [EC:1.6.5.3]
synonym: "dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:1.6.5.3]
synonym: "DPNH-coenzyme Q reductase activity" EXACT [EC:1.6.5.3]
synonym: "DPNH-ubiquinone reductase activity" EXACT [EC:1.6.5.3]
synonym: "electron transfer complex I activity" RELATED [EC:1.6.5.3]
synonym: "mitochondrial electron transport complex 1 activity" NARROW [EC:1.6.5.3]
synonym: "mitochondrial electron transport complex I activity" NARROW [EC:1.6.5.3]
synonym: "NADH coenzyme Q1 reductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH-coenzyme Q oxidoreductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH-coenzyme Q reductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH-CoQ oxidoreductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH-CoQ reductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH-Q6 oxidoreductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH-ubiquinone oxidoreductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH-ubiquinone reductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH-ubiquinone-1 reductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH:ubiquinone oxidoreductase activity" EXACT [EC:1.6.5.3]
synonym: "NADH:ubiquinone oxidoreductase complex activity" RELATED [EC:1.6.5.3]
synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:1.6.5.3]
synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.5.3]
synonym: "ubiquinone reductase activity" EXACT []
xref: EC:1.6.5.3
xref: MetaCyc:NADH-DEHYDROG-A-RXN
xref: MetaCyc:RXN0-5330
xref: Reactome:22973 "NADH dehydrogenase (ubiquinone) activity"
is_a: GO:0050136 ! NADH dehydrogenase (quinone) activity

[Term]
id: GO:0008138
name: protein tyrosine/serine/threonine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate." [GOC:mah]
subset: gosubset_prok
synonym: "dual-specificity protein phosphatase" BROAD []
xref: EC:3.1.3.-
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0008139
name: nuclear localization sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus." [GOC:ai]
synonym: "NLS binding" EXACT []
synonym: "nuclear localization signal binding" EXACT []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0008140
name: cAMP response element binding protein binding
namespace: molecular_function
synonym: "3',5' cAMP response element binding protein binding" EXACT []
synonym: "3',5'-cAMP response element binding protein binding" EXACT []
synonym: "adenosine 3',5'-cyclophosphate response element binding protein binding" EXACT []
synonym: "cyclic AMP response element binding protein binding" EXACT []
is_a: GO:0003713 ! transcription coactivator activity

[Term]
id: GO:0008141
name: puparial glue (sensu Diptera)
namespace: molecular_function
def: "OBSOLETE. A glue which attaches the pupae to the substrate during metamorphosis, as in, but not restricted to, the true flies (Diptera, ncbi_taxonomy_id:7147)." [PMID:825230]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
is_obsolete: true
replaced_by: GO:0005198
replaced_by: GO:0007594

[Term]
id: GO:0008142
name: oxysterol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol." [http://www.onelook.com/]
is_a: GO:0032934 ! sterol binding

[Term]
id: GO:0008143
name: poly(A) RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:krc, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "poly(A) binding" EXACT [GOC:mah]
synonym: "poly(rA) binding" EXACT [GOC:mah]
synonym: "poly-A binding" BROAD [GOC:mah]
synonym: "polyadenylate binding" BROAD [GOC:mah]
is_a: GO:0003729 ! mRNA binding
is_a: GO:0070717 ! poly-purine tract binding

[Term]
id: GO:0008144
name: drug binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0008145
name: phenylalkylamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phenylalkylamine or any of its derivatives." [GOC:jl]
is_a: GO:0008144 ! drug binding

[Term]
id: GO:0008146
name: sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "sulphotransferase activity" EXACT []
xref: EC:2.8.2
xref: Reactome:2397 "sulfotransferase activity"
is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups

[Term]
id: GO:0008147
name: structural constituent of bone
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of bone." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0008148
name: negative transcription elongation factor activity
namespace: molecular_function
def: "Any activity that decreases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah]
is_a: GO:0003711 ! transcription elongation regulator activity

[Term]
id: GO:0008149
name: para-aminobenzoic acid (PABA) synthase
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai, MetaCyc:PABASYN-CPLX]
comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered.
is_obsolete: true
consider: GO:0008696
consider: GO:0046820

[Term]
id: GO:0008150
name: biological_process
namespace: biological_process
alt_id: GO:0000004
alt_id: GO:0007582
def: "Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end." [GOC:go_curators, GOC:isa_complete]
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this.
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "biological process" EXACT []
synonym: "biological process unknown" NARROW []
synonym: "physiological process" EXACT []
xref: Wikipedia:Biological_process

[Term]
id: GO:0008152
name: metabolic process
namespace: biological_process
def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684]
comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "metabolic process resulting in cell growth" NARROW []
synonym: "metabolism" EXACT []
synonym: "metabolism resulting in cell growth" NARROW []
xref: Wikipedia:Metabolism
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0008153
name: para-aminobenzoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11377864, PMID:11960743]
subset: gosubset_prok
synonym: "4-aminobenzoic acid biosynthesis" EXACT []
synonym: "4-aminobenzoic acid biosynthetic process" EXACT []
synonym: "p-aminobenzoic acid biosynthesis" EXACT []
synonym: "p-aminobenzoic acid biosynthetic process" EXACT []
synonym: "PABA biosynthesis" EXACT []
synonym: "PABA biosynthetic process" EXACT []
synonym: "para-aminobenzoic acid anabolism" EXACT []
synonym: "para-aminobenzoic acid biosynthesis" EXACT []
synonym: "para-aminobenzoic acid formation" EXACT []
synonym: "para-aminobenzoic acid synthesis" EXACT []
synonym: "vitamin Bx biosynthesis" EXACT []
synonym: "vitamin Bx biosynthetic process" EXACT []
is_a: GO:0009396 ! folic acid and derivative biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0046482 ! para-aminobenzoic acid metabolic process

[Term]
id: GO:0008154
name: actin polymerization or depolymerization
namespace: biological_process
def: "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah]
is_a: GO:0007015 ! actin filament organization
is_a: GO:0034621 ! cellular macromolecular complex subunit organization

[Term]
id: GO:0008155
name: larval behavior (sensu Drosophila)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term.
is_obsolete: true
replaced_by: GO:0030537

[Term]
id: GO:0008156
name: negative regulation of DNA replication
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators]
subset: gosubset_prok
synonym: "DNA replication inhibitor" RELATED []
synonym: "down regulation of DNA replication" EXACT []
synonym: "down-regulation of DNA replication" EXACT []
synonym: "downregulation of DNA replication" EXACT []
synonym: "inhibition of DNA replication" NARROW []
is_a: GO:0006275 ! regulation of DNA replication
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051053 ! negative regulation of DNA metabolic process
relationship: negatively_regulates GO:0006260 ! DNA replication

[Term]
id: GO:0008157
name: protein phosphatase 1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl]
is_a: GO:0019903 ! protein phosphatase binding

[Term]
id: GO:0008158
name: hedgehog receptor activity
namespace: molecular_function
def: "Combining with the hedgehog protein to initiate a change in cell activity." [GOC:go_curators]
synonym: "patched activity" EXACT []
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0008159
name: positive transcription elongation factor activity
namespace: molecular_function
def: "Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah]
is_a: GO:0003711 ! transcription elongation regulator activity

[Term]
id: GO:0008160
name: protein tyrosine phosphatase activator activity
namespace: molecular_function
def: "Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0019211 ! phosphatase activator activity

[Term]
id: GO:0008161
name: carbamate resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046681

[Term]
id: GO:0008162
name: cyclodiene resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046682

[Term]
id: GO:0008163
name: DDT resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046680

[Term]
id: GO:0008164
name: organophosphorus resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046683

[Term]
id: GO:0008165
name: pyrethroid resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046684

[Term]
id: GO:0008166
name: viral replication
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it covers multiple processes and is now covered by more specific terms.
is_obsolete: true
consider: GO:0019079

[Term]
id: GO:0008167
name: sigma virus replication
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
is_obsolete: true
replaced_by: GO:0019079

[Term]
id: GO:0008168
name: methyltransferase activity
namespace: molecular_function
alt_id: GO:0004480
def: "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "methylase" BROAD []
xref: EC:2.1.1
xref: Reactome:1062 "methyltransferase activity"
is_a: GO:0016741 ! transferase activity, transferring one-carbon groups

[Term]
id: GO:0008169
name: C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008170
name: N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008171
name: O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008172
name: S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.1.1.-
xref: Reactome:9949 "S-methyltransferase activity"
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008173
name: RNA methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah]
comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698).
subset: gosubset_prok
xref: EC:2.1.1.-
xref: Reactome:1979 "RNA methyltransferase activity"
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008174
name: mRNA methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008173 ! RNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008175
name: tRNA methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008173 ! RNA methyltransferase activity

[Term]
id: GO:0008176
name: tRNA (guanine-N7-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine." [EC:2.1.1.33]
subset: gosubset_prok
synonym: "7-methylguanine transfer ribonucleate methylase activity" EXACT [EC:2.1.1.33]
synonym: "N7-methylguanine methylase activity" EXACT [EC:2.1.1.33]
synonym: "S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase activity" EXACT [EC:2.1.1.33]
synonym: "S-adenosyl-L-methionine:tRNA (guanine-N7-)-methyltransferase activity" EXACT [EC:2.1.1.33]
synonym: "transfer ribonucleate guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33]
synonym: "tRNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33]
xref: EC:2.1.1.33
xref: MetaCyc:TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0008177
name: succinate dehydrogenase (ubiquinone) activity
namespace: molecular_function
alt_id: GO:0019737
def: "Catalysis of the reaction: succinate + quinone = fumarate + quinol." [EC:1.3.5.1]
subset: gosubset_prok
synonym: "complex II" RELATED [EC:1.3.5.1]
synonym: "fumarate reductase complex (i.e. FRD, involved in anaerobic respiration, repressed in aerobic respiration)" RELATED [EC:1.3.5.1]
synonym: "menaquinol: fumarate oxidoreductase activity" EXACT [EC:1.3.5.1]
synonym: "quinol:fumarate oxidoreductase activity" EXACT []
synonym: "succinate dehydrogenase complex (i. e. SDH, involved in aerobic respiration, repressed in anaerobic respiration)" RELATED [EC:1.3.5.1]
synonym: "succinate:ubiquinone oxidoreductase activity" EXACT [EC:1.3.5.1]
synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.5.1]
xref: EC:1.3.5.1
xref: MetaCyc:SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN
xref: Reactome:23070 "succinate dehydrogenase (ubiquinone) activity"
is_a: GO:0000104 ! succinate dehydrogenase activity
is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor

[Term]
id: GO:0008179
name: adenylate cyclase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme adenylate cyclase." [GOC:jl]
synonym: "adenylyl cyclase binding" EXACT []
xref: Reactome:23073 "adenylate cyclase binding"
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0008180
name: signalosome
namespace: cellular_component
def: "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571]
synonym: "COP9 complex" NARROW []
synonym: "CSN" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0008181
name: tumor suppressor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not represent a true biological function, rather a pathology that occurs when a particular gene product is inactivated in some way.
is_obsolete: true
consider: GO:0051726

[Term]
id: GO:0008184
name: glycogen phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [EC:2.4.1.1, MetaCyc:GLYCOPHOSPHORYL-RXN]
subset: gosubset_prok
xref: MetaCyc:GLYCOPHOSPHORYL-RXN
xref: Reactome:23099 "glycogen phosphorylase activity"
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0008186
name: RNA-dependent ATPase activity
namespace: molecular_function
alt_id: GO:0004010
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of RNA; drives another reaction." [EC:3.6.1.3, GOC:jl]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "RNA-dependent adenosinetriphosphatase activity" EXACT []
is_a: GO:0042623 ! ATPase activity, coupled

[Term]
id: GO:0008187
name: poly-pyrimidine tract binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule." [GOC:jl]
is_a: GO:0003727 ! single-stranded RNA binding

[Term]
id: GO:0008188
name: neuropeptide receptor activity
namespace: molecular_function
def: "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled
is_a: GO:0030594 ! neurotransmitter receptor activity
is_a: GO:0042923 ! neuropeptide binding

[Term]
id: GO:0008189
name: apoptosis inhibitor activity
namespace: molecular_function
def: "OBSOLETE. The function held by products which directly block any step in the process of apoptosis." [GOC:hb]
comment: This term was made obsolete because it represents involvement in a biological process.
is_obsolete: true
replaced_by: GO:0006916

[Term]
id: GO:0008190
name: eukaryotic initiation factor 4E binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "eIF4E binding" EXACT []
is_a: GO:0031369 ! translation initiation factor binding

[Term]
id: GO:0008191
name: metalloendopeptidase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai]
subset: gosubset_prok
synonym: "metalloprotease inhibitor" BROAD []
synonym: "metalloproteinase inhibitor" BROAD []
is_a: GO:0004866 ! endopeptidase inhibitor activity
is_a: GO:0048551 ! metalloenzyme inhibitor activity

[Term]
id: GO:0008192
name: RNA guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule." [GOC:mah]
xref: EC:2.7.7.-
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0008193
name: tRNA guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs." [PMID:1660461]
xref: EC:2.7.7.-
is_a: GO:0008192 ! RNA guanylyltransferase activity

[Term]
id: GO:0008194
name: UDP-glycosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783]
subset: gosubset_prok
xref: Reactome:23123 "UDP-glycosyltransferase activity"
is_a: GO:0016757 ! transferase activity, transferring glycosyl groups

[Term]
id: GO:0008195
name: phosphatidate phosphatase activity
namespace: molecular_function
alt_id: GO:0004606
def: "Catalysis of the reaction: a 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [EC:3.1.3.4]
synonym: "3-sn-phosphatidate phosphohydrolase activity" EXACT [EC:3.1.3.4]
synonym: "acid phosphatidyl phosphatase activity" EXACT [EC:3.1.3.4]
synonym: "phosphatic acid phosphatase activity" EXACT [EC:3.1.3.4]
synonym: "phosphatic acid phosphohydrolase activity" EXACT [EC:3.1.3.4]
synonym: "phosphatidate phosphohydrolase activity" EXACT []
synonym: "phosphatidic acid phosphatase activity" EXACT [EC:3.1.3.4]
xref: EC:3.1.3.4
xref: MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN
xref: Reactome:23125 "phosphatidate phosphatase activity"
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0008196
name: vitellogenin receptor activity
namespace: molecular_function
def: "Combining with vitellogenin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0008197
name: yolk protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
consider: GO:0005198
consider: GO:0045735

[Term]
id: GO:0008198
name: ferrous iron binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ferrous iron, Fe(II)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005506 ! iron ion binding

[Term]
id: GO:0008199
name: ferric iron binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005506 ! iron ion binding

[Term]
id: GO:0008200
name: ion channel inhibitor activity
namespace: molecular_function
def: "Stops, prevents, or reduces the activity of an ion channel." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016248 ! channel inhibitor activity

[Term]
id: GO:0008201
name: heparin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha1-4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "heparan sulfate binding" RELATED []
is_a: GO:0005539 ! glycosaminoglycan binding

[Term]
id: GO:0008202
name: steroid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684]
subset: gosubset_prok
synonym: "steroid metabolism" EXACT []
xref: Reactome:192076 "Steroid metabolism"
xref: Reactome:448457 "Steroid metabolism"
xref: Reactome:469587 "Steroid metabolism"
xref: Reactome:487306 "Steroid metabolism"
xref: Reactome:507257 "Steroid metabolism"
xref: Reactome:517279 "Steroid metabolism"
xref: Reactome:526157 "Steroid metabolism"
xref: Reactome:531054 "Steroid metabolism"
xref: Reactome:536436 "Steroid metabolism"
xref: Reactome:542133 "Steroid metabolism"
xref: Reactome:547572 "Steroid metabolism"
xref: Reactome:552165 "Steroid metabolism"
xref: Reactome:557753 "Steroid metabolism"
xref: Reactome:568289 "Steroid metabolism"
xref: Reactome:581491 "Steroid metabolism"
xref: Reactome:585787 "Steroid metabolism"
xref: Reactome:592388 "Steroid metabolism"
xref: Reactome:595580 "Steroid metabolism"
xref: Reactome:597301 "Steroid metabolism"
xref: Reactome:598169 "Steroid metabolism"
xref: Reactome:599647 "Steroid metabolism"
xref: Reactome:600705 "Steroid metabolism"
xref: Reactome:602389 "Steroid metabolism"
xref: Wikipedia:Steroid_metabolism
is_a: GO:0006629 ! lipid metabolic process

[Term]
id: GO:0008203
name: cholesterol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cholesterol metabolism" EXACT []
is_a: GO:0016125 ! sterol metabolic process

[Term]
id: GO:0008204
name: ergosterol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ergosterol metabolism" EXACT []
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:0016128 ! phytosteroid metabolic process

[Term]
id: GO:0008205
name: ecdysone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. It is the inactive prohormone of the moulting hormone ecdysterone and may have intrinsic hormonal activity at other stages of insect development." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "ecdysone metabolism" EXACT []
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:0045455 ! ecdysteroid metabolic process

[Term]
id: GO:0008206
name: bile acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:go_curators]
synonym: "bile acid metabolism" EXACT []
xref: Reactome:159431 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine"
xref: Reactome:194068 "Metabolism of bile acids and bile salts"
xref: Reactome:435939 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine"
xref: Reactome:448456 "Metabolism of bile acids and bile salts"
xref: Reactome:458327 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine"
xref: Reactome:469586 "Metabolism of bile acids and bile salts"
xref: Reactome:477788 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine"
xref: Reactome:487305 "Metabolism of bile acids and bile salts"
xref: Reactome:497327 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine"
xref: Reactome:507256 "Metabolism of bile acids and bile salts"
xref: Reactome:517278 "Metabolism of bile acids and bile salts"
xref: Reactome:521704 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine"
xref: Reactome:526156 "Metabolism of bile acids and bile salts"
xref: Reactome:531053 "Metabolism of bile acids and bile salts"
xref: Reactome:536435 "Metabolism of bile acids and bile salts"
xref: Reactome:542132 "Metabolism of bile acids and bile salts"
xref: Reactome:547576 "Metabolism of bile acids and bile salts"
xref: Reactome:552164 "Metabolism of bile acids and bile salts"
xref: Reactome:557752 "Metabolism of bile acids and bile salts"
xref: Reactome:568288 "Metabolism of bile acids and bile salts"
xref: Reactome:581490 "Metabolism of bile acids and bile salts"
xref: Reactome:585786 "Metabolism of bile acids and bile salts"
xref: Reactome:592387 "Metabolism of bile acids and bile salts"
xref: Reactome:595597 "Metabolism of bile acids and bile salts"
xref: Reactome:597300 "Metabolism of bile acids and bile salts"
xref: Reactome:598216 "Metabolism of bile acids and bile salts"
xref: Reactome:599646 "Metabolism of bile acids and bile salts"
xref: Reactome:600704 "Metabolism of bile acids and bile salts"
xref: Reactome:602388 "Metabolism of bile acids and bile salts"
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0008207
name: C21-steroid hormone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai]
synonym: "C21-steroid hormone metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process

[Term]
id: GO:0008208
name: C21-steroid hormone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai]
synonym: "C21-steroid hormone breakdown" EXACT []
synonym: "C21-steroid hormone catabolism" EXACT []
synonym: "C21-steroid hormone degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008207 ! C21-steroid hormone metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0008209
name: androgen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "androgen metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process

[Term]
id: GO:0008210
name: estrogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "estrogen metabolism" EXACT []
synonym: "oestrogen metabolic process" EXACT []
synonym: "oestrogen metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process

[Term]
id: GO:0008211
name: glucocorticoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "glucocorticoid metabolism" EXACT []
synonym: "glucocorticosteroid metabolic process" EXACT []
synonym: "glucocorticosteroid metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process

[Term]
id: GO:0008212
name: mineralocorticoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "mineralocorticoid metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process

[Term]
id: GO:0008213
name: protein amino acid alkylation
namespace: biological_process
def: "The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom." [GOC:ma]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0008214
name: protein amino acid dealkylation
namespace: biological_process
def: "The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0008215
name: spermine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "spermine metabolism" EXACT []
xref: Reactome:141341 "Spermine is oxidized to spermidine"
xref: Reactome:447036 "Spermine is oxidized to spermidine"
xref: Reactome:468309 "Spermine is oxidized to spermidine"
xref: Reactome:486128 "Spermine is oxidized to spermidine"
xref: Reactome:506081 "Spermine is oxidized to spermidine"
xref: Reactome:516708 "Spermine is oxidized to spermidine"
xref: Reactome:525639 "Spermine is oxidized to spermidine"
xref: Reactome:536129 "Spermine is oxidized to spermidine"
xref: Reactome:567634 "Spermine is oxidized to spermidine"
xref: Reactome:580748 "Spermine is oxidized to spermidine"
is_a: GO:0006595 ! polyamine metabolic process

[Term]
id: GO:0008216
name: spermidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai]
subset: gosubset_prok
synonym: "spermidine metabolism" EXACT []
is_a: GO:0006595 ! polyamine metabolic process

[Term]
id: GO:0008217
name: regulation of blood pressure
namespace: biological_process
def: "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"]
synonym: "blood pressure homeostasis" RELATED []
synonym: "blood pressure regulation" EXACT []
synonym: "control of blood pressure" RELATED []
xref: Wikipedia:Blood_pressure#Regulation
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0008015 ! blood circulation

[Term]
id: GO:0008218
name: bioluminescence
namespace: biological_process
def: "The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: Wikipedia:Bioluminescence
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0008219
name: cell death
namespace: biological_process
def: "A biological process that results in permanent cessation of all vital functions of a cell." [GOC:mah]
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: gosubset_prok
synonym: "necrosis" RELATED []
is_a: GO:0009987 ! cellular process
is_a: GO:0016265 ! death

[Term]
id: GO:0008220
name: necrosis
namespace: biological_process
def: "OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism." [GOC:ma]
comment: This term was made obsolete because the term has been used in the literature by groups in different areas of biology with a number of varying explicit and implicit definitions, and more appropriate terms were created.
is_obsolete: true
consider: GO:0001906
consider: GO:0008219
consider: GO:0012501
consider: GO:0019835

[Term]
id: GO:0008222
name: tumor antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
is_obsolete: true

[Term]
id: GO:0008224
name: Gram-positive antibacterial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-positive bacterial cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
is_obsolete: true
consider: GO:0050830

[Term]
id: GO:0008225
name: Gram-negative antibacterial peptide activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-negative bacterial cells." [GOC:go_curators]
comment: This term was made obsolete because it describes involvement in a process and not a function.
is_obsolete: true
consider: GO:0050829

[Term]
id: GO:0008226
name: tyramine receptor activity
namespace: molecular_function
def: "Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine." [http://www.onelook.com/]
is_a: GO:0008227 ! G-protein coupled amine receptor activity

[Term]
id: GO:0008227
name: G-protein coupled amine receptor activity
namespace: molecular_function
def: "A receptor that binds an extracellular amine and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers." [GOC:dph]
subset: gosubset_prok
synonym: "biogenic amine receptor" NARROW []
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0008228
name: opsonization
namespace: biological_process
def: "The process by which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody." [GOC:add, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:068340007X "Stedman's Medical Dictionary", ISBN:0781735149 "Fundamental Immunology"]
xref: Wikipedia:Opsonin
is_a: GO:0002252 ! immune effector process
relationship: part_of GO:0006909 ! phagocytosis

[Term]
id: GO:0008229
name: opsonin activity
namespace: molecular_function
def: "OBSOLETE. Binds to microorganisms or other particulate material (for example, foreign erythrocytes) to increase the susceptibility of the latter to phagocytosis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
consider: GO:0003823

[Term]
id: GO:0008230
name: ecdysone receptor holocomplex
namespace: cellular_component
def: "A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes." [GOC:bf, PMID:14592980]
is_a: GO:0005667 ! transcription factor complex
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0008231
name: repressor ecdysone receptor complex
namespace: cellular_component
def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes." [PMID:10488333]
synonym: "repressor ecdysone receptor holocomplex" RELATED []
is_a: GO:0008230 ! ecdysone receptor holocomplex

[Term]
id: GO:0008232
name: activator ecdysone receptor complex
namespace: cellular_component
def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes." [PMID:10488333]
synonym: "activator ecdysone receptor holocomplex" RELATED []
is_a: GO:0008230 ! ecdysone receptor holocomplex

[Term]
id: GO:0008233
name: peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "hydrolase, acting on peptide bonds" EXACT []
synonym: "peptide hydrolase activity" EXACT []
synonym: "protease activity" EXACT []
synonym: "proteinase activity" EXACT []
xref: EC:3.4
xref: Reactome:1687 "peptidase activity"
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0008234
name: cysteine-type peptidase activity
namespace: molecular_function
alt_id: GO:0004220
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE]
subset: gosubset_prok
synonym: "cysteine protease activity" EXACT []
synonym: "thiol protease activity" EXACT []
xref: EC:3.4.-.-
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0008235
name: metalloexopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#EXOPEPTIDASE]
subset: gosubset_prok
is_a: GO:0008237 ! metallopeptidase activity
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0008236
name: serine-type peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, ISBN:0716720094]
subset: gosubset_prok
synonym: "serine protease activity" EXACT []
is_a: GO:0017171 ! serine hydrolase activity
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0008237
name: metallopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE]
subset: gosubset_prok
synonym: "metalloprotease activity" EXACT [GOC:mah]
synonym: "metalloproteinase activity" EXACT [GOC:mah]
xref: Reactome:1795 "metallopeptidase activity"
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0008238
name: exopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both." [http://merops.sanger.ac.uk/about/about_9.htm#EXOPEPTIDASE]
subset: gosubset_prok
synonym: "exoprotease activity" EXACT []
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0008239
name: dipeptidyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb]
subset: gosubset_prok
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0008240
name: tripeptidyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah]
xref: EC:3.4.14.-
xref: MetaCyc:3.4.14.10-RXN
xref: MetaCyc:3.4.14.9-RXN
is_a: GO:0008236 ! serine-type peptidase activity
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0008241
name: peptidyl-dipeptidase activity
namespace: molecular_function
def: "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb]
subset: gosubset_prok
xref: EC:3.4.15
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0008242
name: omega peptidase activity
namespace: molecular_function
def: "Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-]
subset: gosubset_prok
synonym: "peptidase activity, acting on peptides containing modified amino acids" RELATED []
xref: EC:3.4.19
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0008243
name: plasminogen activator activity
namespace: molecular_function
alt_id: GO:0004296
alt_id: GO:0004297
def: "OBSOLETE. Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin." [EC:3.4.21.68, EC:3.4.21.73]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "abbokinase activity" EXACT [EC:3.4.21.68]
synonym: "cellular plasminogen activator activity" NARROW [EC:3.4.21.-]
synonym: "double-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68]
synonym: "plasminogen activator, tissue-type" RELATED [EC:3.4.21.68]
synonym: "t-PA" RELATED [EC:3.4.21.68]
synonym: "t-plasminogen activator activity" NARROW []
synonym: "tissue plasminogen activator activity" NARROW [EC:3.4.21.-]
synonym: "tissue-type plasminogen activator activity" RELATED [EC:3.4.21.-]
synonym: "tPA activity" NARROW [EC:3.4.21.-]
synonym: "two-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68]
synonym: "u-PA" RELATED [EC:3.4.21.68]
synonym: "u-plasminogen activator activity" NARROW []
synonym: "uPA" RELATED [EC:3.4.21.68]
synonym: "urinary esterase A" RELATED [EC:3.4.21.68]
synonym: "urinary plasminogen activator activity" NARROW [EC:3.4.21.-]
synonym: "urokinase activity" RELATED [EC:3.4.21.-]
synonym: "urokinase plasminogen activator" RELATED [EC:3.4.21.68]
synonym: "urokinase-type plasminogen activator" RELATED [EC:3.4.21.68]
xref: EC:3.4.21.-
xref: EC:3.4.21.68
xref: EC:3.4.21.73
xref: MetaCyc:3.4.21.68-RXN
xref: MetaCyc:3.4.21.73-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008245
name: lysosomal membrane hydrogen-transporting ATPase
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "V-ATPase" RELATED []
is_obsolete: true
consider: GO:0046611

[Term]
id: GO:0008246
name: electron transfer flavoprotein
namespace: molecular_function
def: "OBSOLETE. Works in conjunction with acyl-CoA dehydrogenase to catalyze the oxidation of CoA and reduce ubiquinone. Part of the mitochondrial electron transport system." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "ETF" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0008247
name: 1-alkyl-2-acetylglycerophosphocholine esterase complex
namespace: cellular_component
def: "An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF)." [GOC:jl, PMID:10542206]
comment: See also the molecular function term '1-alkyl-2-acetylglycerophosphocholine esterase activity ; GO:0003847'.
subset: gosubset_prok
synonym: "2-acetyl-1-alkylglycerophosphocholine esterase complex" EXACT []
synonym: "platelet-activating factor acetylhydrolase complex" EXACT []
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0008248
name: pre-mRNA splicing factor activity
namespace: molecular_function
def: "OBSOLETE. An activity involved in the removal of an intron from a pre-mRNA." [GOC:jl]
comment: This term was made obsolete because it describes a biological process.
is_obsolete: true
consider: GO:0008380

[Term]
id: GO:0008250
name: oligosaccharyltransferase complex
namespace: cellular_component
def: "A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected." [ISBN:0879695595, PMID:15835887]
synonym: "oligosaccharyl transferase complex" EXACT []
synonym: "OST complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0008251
name: tRNA-specific adenosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah, IMG:00700]
subset: gosubset_prok
synonym: "tRNA-adenosine deaminase activity" EXACT []
xref: EC:3.5.4.-
is_a: GO:0004000 ! adenosine deaminase activity

[Term]
id: GO:0008252
name: nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [EC:3.1.3.31]
subset: gosubset_prok
synonym: "acid nucleotidase activity" EXACT [EC:3.1.3.31]
synonym: "deoxyinosine-activated nucleotidase (DIAN)" EXACT [EC:3.1.3.31]
synonym: "deoxyribonucleoside-activated nucleotidase (DAN)" EXACT [EC:3.1.3.31]
synonym: "NSP I" RELATED [EC:3.1.3.31]
synonym: "NSP II" RELATED [EC:3.1.3.31]
synonym: "nucleotide phosphohydrolase activity" EXACT [EC:3.1.3.31]
synonym: "nucleotide-specific phosphatase activity" EXACT [EC:3.1.3.31]
xref: EC:3.1.3.31
xref: MetaCyc:NUCLEOTIDASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0008253
name: 5'-nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5]
subset: gosubset_prok
synonym: "5' nucleotidase activity" EXACT []
synonym: "5'-adenylic phosphatase" NARROW [EC:3.1.3.5]
synonym: "5'-AMP nucleotidase" NARROW [EC:3.1.3.5]
synonym: "5'-AMPase" NARROW [EC:3.1.3.5]
synonym: "5'-mononucleotidase activity" EXACT [EC:3.1.3.5]
synonym: "5'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.5]
synonym: "adenosine 5'-phosphatase" NARROW [EC:3.1.3.5]
synonym: "adenosine monophosphatase" NARROW [EC:3.1.3.5]
synonym: "AMP phosphatase" NARROW [EC:3.1.3.5]
synonym: "AMP phosphohydrolase" NARROW [EC:3.1.3.5]
synonym: "AMPase" NARROW [EC:3.1.3.5]
synonym: "snake venom 5'-nucleotidase" NARROW [EC:3.1.3.5]
synonym: "thimidine monophosphate nucleotidase" NARROW [EC:3.1.3.5]
synonym: "UMPase" NARROW [EC:3.1.3.5]
synonym: "uridine 5'-nucleotidase" NARROW [EC:3.1.3.5]
xref: EC:3.1.3.5
xref: MetaCyc:5-NUCLEOTID-RXN
xref: Reactome:23614 "5'-nucleotidase activity"
is_a: GO:0008252 ! nucleotidase activity

[Term]
id: GO:0008254
name: 3'-nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.6]
synonym: "3' nucleotidase activity" EXACT []
synonym: "3'-mononucleotidase activity" EXACT [EC:3.1.3.6]
synonym: "3'-phosphatase activity" EXACT [EC:3.1.3.6]
synonym: "3'-ribonucleotidase activity" EXACT [EC:3.1.3.6]
synonym: "3'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.6]
xref: EC:3.1.3.6
xref: MetaCyc:3-NUCLEOTID-RXN
is_a: GO:0008252 ! nucleotidase activity

[Term]
id: GO:0008255
name: ecdysis-triggering hormone activity
namespace: molecular_function
def: "The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system." [GOC:mah, PMID:9020043]
is_a: GO:0005184 ! neuropeptide hormone activity

[Term]
id: GO:0008256
name: protein histidine pros-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine." [EC:2.7.13.1]
subset: gosubset_prok
synonym: "ATP:protein-L-histidine N-pros-phosphotransferase activity" EXACT [EC:2.7.13.1]
synonym: "ATP:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.13.1]
synonym: "HK2" RELATED [EC:2.7.13.1]
synonym: "protein-histidine pros-kinase activity" EXACT [EC:2.7.13.1]
xref: EC:2.7.13.1
xref: MetaCyc:2.7.13.1-RXN
is_a: GO:0004673 ! protein histidine kinase activity

[Term]
id: GO:0008257
name: protein histidine tele-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine." [EC:2.7.13.2]
synonym: "ATP:protein-L-histidine N-tele-phosphotransferase activity" EXACT [EC:2.7.13.2]
synonym: "ATP:protein-L-histidine Ntau-phosphotransferase activity" EXACT [EC:2.7.13.2]
synonym: "HK3" RELATED [EC:2.7.13.2]
synonym: "protein-histidine tele-kinase activity" EXACT [EC:2.7.13.2]
xref: EC:2.7.13.2
xref: MetaCyc:2.7.13.2-RXN
is_a: GO:0004673 ! protein histidine kinase activity

[Term]
id: GO:0008258
name: head involution
namespace: biological_process
def: "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0008259
name: transforming growth factor beta ligand binding to type I receptor
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a function.
synonym: "TGF-beta ligand binding to type I receptor" EXACT []
synonym: "TGFbeta ligand binding to type I receptor" EXACT []
is_obsolete: true
consider: GO:0005025
consider: GO:0005160
consider: GO:0050431

[Term]
id: GO:0008260
name: 3-oxoacid CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA." [EC:2.8.3.5]
subset: gosubset_prok
synonym: "3-ketoacid CoA-transferase activity" EXACT [EC:2.8.3.5]
synonym: "3-ketoacid coenzyme A transferase activity" EXACT [EC:2.8.3.5]
synonym: "3-oxo-CoA transferase activity" EXACT [EC:2.8.3.5]
synonym: "3-oxoacid CoA dehydrogenase activity" EXACT [EC:2.8.3.5]
synonym: "3-oxoacid coenzyme A-transferase activity" EXACT [EC:2.8.3.5]
synonym: "acetoacetate succinyl-CoA transferase activity" EXACT [EC:2.8.3.5]
synonym: "acetoacetyl coenzyme A-succinic thiophorase activity" EXACT [EC:2.8.3.5]
synonym: "succinyl coenzyme A-acetoacetyl coenzyme A-transferase activity" EXACT [EC:2.8.3.5]
synonym: "succinyl-CoA transferase activity" EXACT [EC:2.8.3.5]
synonym: "succinyl-CoA:3-ketoacid-CoA transferase activity" EXACT [EC:2.8.3.5]
synonym: "succinyl-CoA:3-oxo-acid CoA-transferase activity" EXACT [EC:2.8.3.5]
xref: EC:2.8.3.5
xref: MetaCyc:3-OXOACID-COA-TRANSFERASE-RXN
xref: Reactome:23643 "3-oxoacid CoA-transferase activity"
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0008261
name: allatostatin receptor activity
namespace: molecular_function
def: "Combining with allatostatin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0008262
name: importin-alpha export receptor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with importin-alpha to mediate its transfer through the nuclear pore to the cytoplasm." [GOC:mah, GOC:vw, PMID:12486120]
synonym: "importin-alpha binding" RELATED []
is_a: GO:0005049 ! nuclear export signal receptor activity
is_a: GO:0008565 ! protein transporter activity

[Term]
id: GO:0008263
name: pyrimidine-specific mismatch base pair DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site." [GOC:elh, PMID:9224623]
synonym: "G/T-mismatch-specific thymine-DNA glycosylase activity" EXACT []
is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity

[Term]
id: GO:0008265
name: Mo-molybdopterin cofactor sulfurase activity
namespace: molecular_function
def: "Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase." [GOC:mah, PMID:11549764]
synonym: "Mo-molybdopterin cofactor sulphurase activity" EXACT []
synonym: "molybdopterin cofactor sulfurase activity" EXACT []
synonym: "molybdopterin synthase sulfurylase activity" EXACT []
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0008266
name: poly(U) RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule." [GOC:mah]
synonym: "poly(U) binding" EXACT [GOC:mah]
is_a: GO:0008187 ! poly-pyrimidine tract binding

[Term]
id: GO:0008267
name: poly-glutamine tract binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein." [GOC:mah]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0008268
name: receptor signaling protein tyrosine kinase signaling protein activity
namespace: molecular_function
synonym: "receptor signalling protein tyrosine kinase signalling protein activity" EXACT []
is_a: GO:0005057 ! receptor signaling protein activity

[Term]
id: GO:0008269
name: JAK pathway signal transduction adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together a molecule of the JAK signal transduction pathway and one or more other molecules of the pathway, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07]
is_a: GO:0008268 ! receptor signaling protein tyrosine kinase signaling protein activity
is_a: GO:0060090 ! molecular adaptor activity

[Term]
id: GO:0008270
name: zinc ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai]
subset: gosubset_prok
synonym: "zinc binding" EXACT []
xref: Reactome:23683 "zinc ion binding"
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0008271
name: secondary active sulfate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
subset: gosubset_prok
synonym: "secondary active sulphate transmembrane transporter activity" EXACT []
synonym: "sulfate porter activity" RELATED []
synonym: "sulphate porter activity" EXACT []
is_a: GO:0015116 ! sulfate transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0008272
name: sulfate transport
namespace: biological_process
alt_id: GO:0006870
def: "The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
synonym: "sulphate transport" EXACT []
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0008273
name: calcium, potassium:sodium antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1]
synonym: "potassium-dependent sodium/calcium exchanger" RELATED []
is_a: GO:0015368 ! calcium:cation antiporter activity

[Term]
id: GO:0008274
name: gamma-tubulin ring complex
namespace: cellular_component
def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule." [GOC:clt, PMID:12134075]
synonym: "gammaTuRC" EXACT []
is_a: GO:0000931 ! gamma-tubulin large complex

[Term]
id: GO:0008275
name: gamma-tubulin small complex
namespace: cellular_component
def: "A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [PMID:11297925, PMID:12134075]
synonym: "gammaTuSC" EXACT []
is_a: GO:0000930 ! gamma-tubulin complex

[Term]
id: GO:0008276
name: protein methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008277
name: regulation of G-protein coupled receptor protein signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators]
synonym: "regulation of G protein coupled receptor protein signaling pathway" EXACT []
synonym: "regulation of G protein coupled receptor protein signalling pathway" EXACT []
synonym: "regulation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "regulation of G-protein-coupled receptor protein signaling pathway" EXACT []
synonym: "regulation of G-protein-coupled receptor protein signalling pathway" EXACT []
synonym: "regulation of GPCR protein signaling pathway" EXACT []
synonym: "regulation of GPCR protein signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0008278
name: cohesin complex
namespace: cellular_component
alt_id: GO:0008279
def: "A protein complex required for sister chromatid cohesion in eukaryotes." [PMID:9887095]
subset: goslim_pir
synonym: "14S cohesin" NARROW []
synonym: "SMC complex" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0008280
name: cohesin core heterodimer
namespace: cellular_component
def: "The core heterodimer of a cohesin complex; a structure required for sister chromatid cohesion in eukaryotes." [GOC:jl]
synonym: "9S cohesin" NARROW []
synonym: "Smc1-Smc3 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0008278 ! cohesin complex

[Term]
id: GO:0008281
name: sulfonylurea receptor activity
namespace: molecular_function
def: "Combining with sulfonylurea to initiate a change in cell activity." [GOC:ai]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'potassium channel activity ; GO:0005267'.
synonym: "sulphonylurea receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0008282
name: ATP-sensitive potassium channel complex
namespace: cellular_component
def: "A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.2 subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SUR1 subunit stimulates channel activity." [PMID:16308567, PMID:16956886]
is_a: GO:0034702 ! ion channel complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0008283
name: cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb]
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0008284
name: positive regulation of cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of cell proliferation" NARROW []
synonym: "stimulation of cell proliferation" NARROW []
synonym: "up regulation of cell proliferation" EXACT []
synonym: "up-regulation of cell proliferation" EXACT []
synonym: "upregulation of cell proliferation" EXACT []
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0008283 ! cell proliferation

[Term]
id: GO:0008285
name: negative regulation of cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators]
synonym: "down regulation of cell proliferation" EXACT []
synonym: "down-regulation of cell proliferation" EXACT []
synonym: "downregulation of cell proliferation" EXACT []
synonym: "inhibition of cell proliferation" NARROW []
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0008283 ! cell proliferation

[Term]
id: GO:0008286
name: insulin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb]
synonym: "daf-2 receptor signaling pathway" NARROW []
synonym: "insulin receptor signalling pathway" EXACT []
xref: Reactome:448649 "Signaling by Insulin receptor"
xref: Reactome:469777 "Signaling by Insulin receptor"
xref: Reactome:487471 "Signaling by Insulin receptor"
xref: Reactome:507431 "Signaling by Insulin receptor"
xref: Reactome:517434 "Signaling by Insulin receptor"
xref: Reactome:526308 "Signaling by Insulin receptor"
xref: Reactome:531186 "Signaling by Insulin receptor"
xref: Reactome:536556 "Signaling by Insulin receptor"
xref: Reactome:542282 "Signaling by Insulin receptor"
xref: Reactome:547623 "Signaling by Insulin receptor"
xref: Reactome:552375 "Signaling by Insulin receptor"
xref: Reactome:557817 "Signaling by Insulin receptor"
xref: Reactome:568631 "Signaling by Insulin receptor"
xref: Reactome:581835 "Signaling by Insulin receptor"
xref: Reactome:585997 "Signaling by Insulin receptor"
xref: Reactome:592533 "Signaling by Insulin receptor"
xref: Reactome:595476 "Signaling by Insulin receptor"
xref: Reactome:74752 "Signaling by Insulin receptor"
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway
is_a: GO:0032869 ! cellular response to insulin stimulus

[Term]
id: GO:0008287
name: protein serine/threonine phosphatase complex
namespace: cellular_component
def: "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0008288
name: boss receptor activity
namespace: molecular_function
def: "Combining with the protein bride of sevenless (boss) to initiate a change in cell activity." [GOC:jl]
synonym: "sevenless receptor activity" RELATED []
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity

[Term]
id: GO:0008289
name: lipid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lipid." [GOC:ai]
subset: goslim_candida
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0008290
name: F-actin capping protein complex
namespace: cellular_component
def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments." [GOC:go_curators, ISBN:0198599560]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0008291
name: acetylcholine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752]
synonym: "acetylcholine metabolism" EXACT []
is_a: GO:0042133 ! neurotransmitter metabolic process
is_a: GO:0042439 ! ethanolamine and derivative metabolic process

[Term]
id: GO:0008292
name: acetylcholine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752]
synonym: "acetylcholine anabolism" EXACT []
synonym: "acetylcholine biosynthesis" EXACT []
synonym: "acetylcholine formation" EXACT []
synonym: "acetylcholine synthesis" EXACT []
is_a: GO:0008291 ! acetylcholine metabolic process
is_a: GO:0042136 ! neurotransmitter biosynthetic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process

[Term]
id: GO:0008293
name: torso signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the torso transmembrane receptor tyrosine kinase binding to its physiological ligand." [GOC:go_curators]
synonym: "torso signalling pathway" EXACT []
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0008294
name: calcium- and calmodulin-responsive adenylate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin." [EC:4.6.1.1, GOC:mah]
synonym: "calcium- and calmodulin-responsive adenylyl cyclase activity" EXACT []
synonym: "calcium/calmodulin-responsive adenylate cyclase activity" EXACT []
xref: Reactome:23748 "calcium- and calmodulin-responsive adenylate cyclase activity"
is_a: GO:0004016 ! adenylate cyclase activity

[Term]
id: GO:0008295
name: spermidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "spermidine anabolism" EXACT []
synonym: "spermidine biosynthesis" EXACT []
synonym: "spermidine formation" EXACT []
synonym: "spermidine synthesis" EXACT []
xref: MetaCyc:BSUBPOLYAMSYN-PWY
xref: MetaCyc:POLYAMINSYN3-PWY
is_a: GO:0006596 ! polyamine biosynthetic process
is_a: GO:0008216 ! spermidine metabolic process

[Term]
id: GO:0008296
name: 3'-5'-exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah]
synonym: "3'-5' exodeoxyribonuclease activity" EXACT []
is_a: GO:0008408 ! 3'-5' exonuclease activity
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008297
name: single-stranded DNA specific exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule." [GOC:mah]
subset: gosubset_prok
synonym: "ssDNA-specific exodeoxyribonuclease activity" EXACT [GOC:mah]
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008298
name: intracellular mRNA localization
namespace: biological_process
def: "Any process by which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of intracellular RNA localization" EXACT []
synonym: "intracellular mRNA positioning" NARROW []
synonym: "mRNA localization, intracellular" EXACT []
synonym: "mRNA positioning, intracellular" NARROW []
is_a: GO:0006403 ! RNA localization
is_a: GO:0070727 ! cellular macromolecule localization

[Term]
id: GO:0008299
name: isoprenoid biosynthetic process
namespace: biological_process
alt_id: GO:0009241
def: "The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "isoprenoid anabolism" EXACT []
synonym: "isoprenoid biosynthesis" EXACT []
synonym: "isoprenoid formation" EXACT []
synonym: "isoprenoid synthesis" EXACT []
synonym: "polyisoprenoid anabolism" NARROW []
synonym: "polyisoprenoid biosynthesis" NARROW []
synonym: "polyisoprenoid biosynthetic process" NARROW []
synonym: "polyisoprenoid formation" NARROW []
synonym: "polyisoprenoid synthesis" NARROW []
synonym: "polyterpene biosynthesis" NARROW []
synonym: "polyterpene biosynthetic process" NARROW []
xref: MetaCyc:POLYISOPRENSYN-PWY
is_a: GO:0006720 ! isoprenoid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0008300
name: isoprenoid catabolic process
namespace: biological_process
alt_id: GO:0016097
def: "The chemical reactions and pathways resulting in the breakdown of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "isoprenoid breakdown" EXACT []
synonym: "isoprenoid catabolism" EXACT []
synonym: "isoprenoid degradation" EXACT []
synonym: "polyisoprenoid breakdown" NARROW []
synonym: "polyisoprenoid catabolic process" NARROW []
synonym: "polyisoprenoid catabolism" NARROW []
synonym: "polyisoprenoid degradation" NARROW []
synonym: "polyterpene catabolic process" NARROW []
synonym: "polyterpene catabolism" NARROW []
is_a: GO:0006720 ! isoprenoid metabolic process
is_a: GO:0044242 ! cellular lipid catabolic process

[Term]
id: GO:0008301
name: DNA bending activity
namespace: molecular_function
def: "An activity that results in binding to DNA and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, PMID:10710711, PMID:19037758]
subset: gosubset_prok
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0008302
name: female germline ring canal formation, actin assembly
namespace: biological_process
def: "Recruitment and organization of actin filaments in female germline ring canals." [ISBN:0879694238]
synonym: "nurse cell ring canal formation, actin assembly" NARROW []
synonym: "ovarian ring canal formation, actin assembly" NARROW []
synonym: "ring canal formation, actin assembly" BROAD []
is_a: GO:0007015 ! actin filament organization
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007301 ! female germline ring canal formation

[Term]
id: GO:0008303
name: caspase complex
namespace: cellular_component
def: "A protein complex that is located in the cytosol and acts as a cysteine-type endopeptidase are involved in apoptosis; the peptidase activity has specificity for the hydrolysis of aspartyl bonds." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0008304
name: eukaryotic translation initiation factor 4 complex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
synonym: "eIF-4" EXACT []
is_obsolete: true
replaced_by: GO:0016281

[Term]
id: GO:0008305
name: integrin complex
namespace: cellular_component
def: "A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136]
subset: gosubset_prok
synonym: "laminin receptor protein" RELATED []
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0008306
name: associative learning
namespace: biological_process
def: "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089]
synonym: "classical conditioning" EXACT []
synonym: "conditional learning" EXACT []
synonym: "conditional response" EXACT []
synonym: "Pavlovian conditioning" EXACT []
xref: Wikipedia:Learning#Associative_learning
is_a: GO:0007612 ! learning

[Term]
id: GO:0008307
name: structural constituent of muscle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0008308
name: voltage-gated anion channel activity
namespace: molecular_function
alt_id: GO:0022844
def: "Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion." [GOC:mtg_transport, ISBN:0815340729]
synonym: "voltage-dependent ion-selective channel activity" RELATED []
synonym: "voltage-gated ion-selective channel activity" RELATED []
is_a: GO:0005244 ! voltage-gated ion channel activity
is_a: GO:0005253 ! anion channel activity

[Term]
id: GO:0008309
name: double-stranded DNA specific exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule." [GOC:mah]
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008310
name: single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah]
synonym: "ssDNA-specific 3'-5' exodeoxyribonuclease activity" EXACT [GOC:mah]
is_a: GO:0008296 ! 3'-5'-exodeoxyribonuclease activity
is_a: GO:0008297 ! single-stranded DNA specific exodeoxyribonuclease activity

[Term]
id: GO:0008311
name: double-stranded DNA specific 3'-5' exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah]
is_a: GO:0008296 ! 3'-5'-exodeoxyribonuclease activity
is_a: GO:0008309 ! double-stranded DNA specific exodeoxyribonuclease activity

[Term]
id: GO:0008312
name: 7S RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418]
subset: gosubset_prok
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0008313
name: gurken receptor activity
namespace: molecular_function
def: "Combining with the ligand Gurken to initiate a change in cell activity." [GOC:bf]
is_a: GO:0005006 ! epidermal growth factor receptor activity

[Term]
id: GO:0008314
name: gurken receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to the ligand Gurken." [GOC:bf]
synonym: "gurken receptor signalling pathway" EXACT []
is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway

[Term]
id: GO:0008315
name: meiotic G2/MI transition
namespace: biological_process
def: "The cell cycle process whereby a cell progresses from meiotic prophase to metaphase I." [PMID:15088480]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0008316
name: structural constituent of vitelline membrane
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0008317
name: gurken receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the gurken growth factor receptor." [GOC:ai]
synonym: "gurken receptor ligand" NARROW []
is_a: GO:0005154 ! epidermal growth factor receptor binding

[Term]
id: GO:0008318
name: protein prenyltransferase activity
namespace: molecular_function
alt_id: GO:0008244
def: "Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah]
xref: EC:2.5.1.-
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0008319
name: prenyl protein specific endopeptidase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
xref: EC:3.4.24.-
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008320
name: protein transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a protein from one side of a membrane to the other." [GOC:jl]
subset: gosubset_prok
is_a: GO:0005515 ! protein binding
is_a: GO:0008565 ! protein transporter activity
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0008321
name: Ral guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ral family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
xref: Reactome:24053 "Ral guanyl-nucleotide exchange factor activity"
is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity

[Term]
id: GO:0008322
name: Pro-X carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0030536

[Term]
id: GO:0008324
name: cation transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:df, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "transmembrane cation transporter activity" EXACT []
is_a: GO:0015075 ! ion transmembrane transporter activity

[Term]
id: GO:0008327
name: methyl-CpG binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide." [GOC:jl, PMID:11746232]
is_a: GO:0000166 ! nucleotide binding
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0008328
name: ionotropic glutamate receptor complex
namespace: cellular_component
def: "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0008329
name: pattern recognition receptor activity
namespace: molecular_function
def: "Combining with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity. Such molecular patterns are sometimes associated with potential pathogens." [PMID:12507420, PMID:12925128, PMID:14523544]
comment: Note that this term and its child terms are intended for gene products which are directly coupled to a signal transduction pathway; gene products which recognize polymeric structures such as polysaccharides or peptidoglycans in extracellular space, but are not directly coupled to signal transduction pathway, should use the term 'pattern binding ; GO:0001871' or its child terms. Note that many gene products that are called pattern recognition receptors in the literature have a broad range of potential ligands and also can be annotated to 'scavenger receptor activity ; GO:0005044'.
synonym: "macrophage receptor activity" RELATED []
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0008330
name: protein tyrosine/threonine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein threonine/tyrosine phosphate + H2O = protein threonine/tyrosine + phosphate." [GOC:mah]
xref: EC:3.1.3.-
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0008331
name: high voltage-gated calcium channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a calcium ion by a high voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729]
synonym: "high voltage gated calcium channel activity" EXACT []
synonym: "high voltage-dependent calcium channel activity" EXACT []
is_a: GO:0005245 ! voltage-gated calcium channel activity

[Term]
id: GO:0008332
name: low voltage-gated calcium channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a calcium ion by a low voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729]
synonym: "low voltage gated calcium channel activity" EXACT []
synonym: "low voltage-dependent calcium channel activity" EXACT []
synonym: "T-type channel" EXACT []
is_a: GO:0005245 ! voltage-gated calcium channel activity

[Term]
id: GO:0008333
name: endosome to lysosome transport
namespace: biological_process
def: "The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363]
is_a: GO:0007041 ! lysosomal transport
is_a: GO:0016197 ! endosome transport

[Term]
id: GO:0008334
name: histone mRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an mRNA encoding a histone." [GOC:mah]
synonym: "histone mRNA metabolism" EXACT []
is_a: GO:0016071 ! mRNA metabolic process

[Term]
id: GO:0008335
name: female germline ring canal stabilization
namespace: biological_process
def: "Maintenance of the structural integrity of the ring canals connecting the female germline cyst." [GOC:curators]
synonym: "nurse cell ring canal stabilization" NARROW []
synonym: "ovarian ring canal stabilization" NARROW []
is_a: GO:0031032 ! actomyosin structure organization
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport

[Term]
id: GO:0008336
name: gamma-butyrobetaine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2." [EC:1.14.11.1]
subset: gosubset_prok
synonym: "4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.1]
synonym: "alpha-butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1]
synonym: "butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1]
synonym: "g-butyrobetaine dioxygenase activity" EXACT []
synonym: "gamma-BBH activity" EXACT [EC:1.14.11.1]
synonym: "gamma-butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1]
synonym: "gamma-butyrobetaine,2-oxoglutarate dioxygenase activity" EXACT []
xref: EC:1.14.11.1
xref: MetaCyc:1.14.11.1-RXN
xref: Reactome:24086 "gamma-butyrobetaine dioxygenase activity"
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0008337
name: selectin
namespace: molecular_function
def: "OBSOLETE. A class of cell adhesion molecules that bind to carbohydrate via a lectin-like domain; integral membrane glycoproteins." [ISBN:0124325653]
comment: This term was made obsolete because it describes a class of gene products.
is_obsolete: true
consider: GO:0005102
consider: GO:0007155
consider: GO:0016021
consider: GO:0030246
consider: GO:0050839

[Term]
id: GO:0008338
name: MAP kinase 1 activity
namespace: molecular_function
synonym: "ERK1" EXACT []
xref: EC:2.7.11.-
xref: MetaCyc:2.7.11.24-RXN
is_a: GO:0004707 ! MAP kinase activity

[Term]
id: GO:0008339
name: MP kinase activity
namespace: molecular_function
synonym: "Mpk2" NARROW []
synonym: "p38" NARROW []
synonym: "SAPK2" NARROW []
xref: EC:2.7.11.-
is_a: GO:0016909 ! SAP kinase activity

[Term]
id: GO:0008340
name: determination of adult lifespan
namespace: biological_process
def: "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0010259 ! multicellular organismal aging

[Term]
id: GO:0008341
name: response to cocaine (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a mature individual as the result of a cocaine stimulus. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, GOC:jic]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
is_obsolete: true
consider: GO:0048148

[Term]
id: GO:0008342
name: larval feeding behavior (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. Feeding behavior in an insect larva." [GOC:jic, GOC:mah]
comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term.
is_obsolete: true
replaced_by: GO:0030536

[Term]
id: GO:0008343
name: adult feeding behavior
namespace: biological_process
def: "Feeding behavior in a fully developed and mature organism." [GOC:mah]
comment: See also the biological process term 'feeding behavior ; GO:0007631'.
synonym: "adult feeding behaviour" EXACT []
is_a: GO:0007631 ! feeding behavior
is_a: GO:0030534 ! adult behavior

[Term]
id: GO:0008344
name: adult locomotory behavior
namespace: biological_process
def: "Locomotory behavior in a fully developed and mature organism." [GOC:ai]
comment: See also the biological process term 'locomotory behavior ; GO:0007626'.
synonym: "adult locomotory behaviour" EXACT []
is_a: GO:0007626 ! locomotory behavior
is_a: GO:0030534 ! adult behavior

[Term]
id: GO:0008345
name: larval locomotory behavior
namespace: biological_process
def: "Locomotory behavior in a larval (immature) organism." [GOC:ai]
comment: See also the biological process term 'locomotory behavior ; GO:0007626'.
synonym: "larval locomotory behaviour" EXACT []
is_a: GO:0007626 ! locomotory behavior
is_a: GO:0030537 ! larval behavior

[Term]
id: GO:0008346
name: larval walking behavior
namespace: biological_process
def: "The actions or reactions of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:go_curators]
synonym: "larval walking behaviour" EXACT []
is_a: GO:0008345 ! larval locomotory behavior

[Term]
id: GO:0008347
name: glial cell migration
namespace: biological_process
alt_id: GO:0043359
def: "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu]
synonym: "glia cell migration" EXACT []
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0042063 ! gliogenesis

[Term]
id: GO:0008348
name: negative regulation of antimicrobial humoral response
namespace: biological_process
alt_id: GO:0042154
alt_id: GO:0042155
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response." [GOC:go_curators]
synonym: "attenuation of antimicrobial humoral response" EXACT []
synonym: "down regulation of antimicrobial humoral response" EXACT []
synonym: "down-regulation of antimicrobial humoral response" EXACT []
synonym: "downregulation of antimicrobial humoral response" EXACT []
synonym: "inhibition of antimicrobial humoral response" NARROW []
is_a: GO:0002759 ! regulation of antimicrobial humoral response
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0002921 ! negative regulation of humoral immune response
is_a: GO:0043901 ! negative regulation of multi-organism process
relationship: negatively_regulates GO:0019730 ! antimicrobial humoral response

[Term]
id: GO:0008349
name: MAP kinase kinase kinase kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [GOC:bf, PMID:11790549]
synonym: "MAPKKKK" EXACT []
xref: EC:2.7.11.-
is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity

[Term]
id: GO:0008350
name: kinetochore motor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it includes cellular component information.
is_obsolete: true
consider: GO:0000776
consider: GO:0003777

[Term]
id: GO:0008351
name: microtubule severing activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a biological process.
is_obsolete: true
replaced_by: GO:0008017
replaced_by: GO:0051013

[Term]
id: GO:0008352
name: katanin complex
namespace: cellular_component
def: "A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766]
comment: Consider also annotating to the molecular function term 'microtubule-severing ATPase activity ; GO:0008568'.
is_a: GO:0005875 ! microtubule associated complex
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0008353
name: RNA polymerase II carboxy-terminal domain kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah]
synonym: "[RNA-polymerase]-subunit kinase activity" BROAD []
synonym: "ATP:DNA-directed RNA polymerase phosphotransferase activity" BROAD [EC:2.7.11.23]
synonym: "CTD kinase activity" EXACT [EC:2.7.11.23]
synonym: "RNA polymerase subunit kinase activity" BROAD [EC:2.7.11.23]
synonym: "RNA-polymerase-subunit kinase activity" BROAD [EC:2.7.11.23]
synonym: "STK9" RELATED [EC:2.7.11.23]
xref: EC:2.7.11.23
xref: MetaCyc:RNA-POLYMERASE-SUBUNIT-KINASE-RXN
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0008354
name: germ cell migration
namespace: biological_process
def: "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl]
synonym: "germ-cell migration" EXACT []
synonym: "primordial germ cell migration" RELATED []
is_a: GO:0016477 ! cell migration
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007276 ! gamete generation

[Term]
id: GO:0008355
name: olfactory learning
namespace: biological_process
def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089]
is_a: GO:0007612 ! learning
is_a: GO:0042048 ! olfactory behavior

[Term]
id: GO:0008356
name: asymmetric cell division
namespace: biological_process
def: "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519]
synonym: "asymmetric cytokinesis" RELATED []
synonym: "asymmetrical cell division" EXACT []
synonym: "asymmetrical cytokinesis" RELATED []
xref: Wikipedia:Asymmetric_cell_division
is_a: GO:0051301 ! cell division

[Term]
id: GO:0008358
name: maternal determination of anterior/posterior axis, embryo
namespace: biological_process
def: "The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
is_a: GO:0008595 ! anterior/posterior axis specification, embryo

[Term]
id: GO:0008359
name: regulation of bicoid mRNA localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process by which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:hb]
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0060281 ! regulation of oocyte development
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0045450 ! bicoid mRNA localization

[Term]
id: GO:0008360
name: regulation of cell shape
namespace: biological_process
alt_id: GO:0045788
alt_id: GO:0045789
def: "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb]
subset: gosubset_prok
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0008361
name: regulation of cell size
namespace: biological_process
def: "Any process that modulates the size of a cell." [GOC:go_curators]
subset: gosubset_prok
synonym: "cell size control" EXACT []
is_a: GO:0032535 ! regulation of cellular component size

[Term]
id: GO:0008362
name: chitin-based embryonic cuticle biosynthetic process
namespace: biological_process
def: "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232]
synonym: "embryonic cuticle anabolism" BROAD []
synonym: "embryonic cuticle biosynthetic process" BROAD []
synonym: "embryonic cuticle formation" BROAD []
synonym: "embryonic cuticle synthesis" BROAD []
is_a: GO:0040003 ! chitin-based cuticle development

[Term]
id: GO:0008363
name: larval chitin-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
synonym: "larval cuticle anabolism" BROAD []
synonym: "larval cuticle biosynthetic process" BROAD []
synonym: "larval cuticle formation" BROAD []
synonym: "larval cuticle synthesis" BROAD []
is_a: GO:0042337 ! chitin-based cuticle development during molting
relationship: part_of GO:0002168 ! instar larval development

[Term]
id: GO:0008364
name: pupal chitin-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of a chitin-based pupal cuticle. At the end of the prepupal period the insect is covered by the pupal cuticle which continues to be elaborated into the pupal period. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
synonym: "pupal cuticle anabolism" BROAD []
synonym: "pupal cuticle formation" BROAD []
synonym: "pupal cuticle synthesis" BROAD []
is_a: GO:0042337 ! chitin-based cuticle development during molting
relationship: part_of GO:0035209 ! pupal development

[Term]
id: GO:0008365
name: adult chitin-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of the chitin-based cuticle of adults following the apolysis of the pupal cuticle. The adult insect cuticle contains cuticullin, a protein epicuticle and a lamellate procuticle. An example of this process is adult chitin-based cuticle development in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
synonym: "adult chitin-based cuticle anabolism" EXACT []
synonym: "adult chitin-based cuticle biosynthetic process" EXACT []
synonym: "adult chitin-based cuticle formation" EXACT []
synonym: "adult chitin-based cuticle synthesis" EXACT []
synonym: "adult cuticle anabolism" BROAD []
synonym: "adult cuticle biosynthetic process" BROAD []
synonym: "adult cuticle formation" BROAD []
synonym: "adult cuticle synthesis" BROAD []
is_a: GO:0040003 ! chitin-based cuticle development

[Term]
id: GO:0008366
name: axon ensheathment
namespace: biological_process
alt_id: GO:0042553
def: "Any process by which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437]
synonym: "cellular axon ensheathment" EXACT []
synonym: "cellular nerve ensheathment" RELATED []
synonym: "nerve ensheathment" RELATED []
is_a: GO:0007272 ! ensheathment of neurons

[Term]
id: GO:0008367
name: bacterial binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of a bacterial cell." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "bacterium binding" EXACT []
synonym: "binding to bacterium" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0008368
name: Gram-negative bacterial binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of a Gram-negative bacterial cell." [GOC:jl]
subset: gosubset_prok
synonym: "binding to Gram-negative bacterium" EXACT []
synonym: "Gram-negative bacterium binding" EXACT []
is_a: GO:0008367 ! bacterial binding

[Term]
id: GO:0008369
name: obsolete molecular function
namespace: molecular_function
def: "OBSOLETE. These are terms that have been removed from the active function ontology." [GOC:go_curators]
comment: This term was made obsolete because it is unnecessary in the OBO flat file format.
is_obsolete: true

[Term]
id: GO:0008370
name: obsolete cellular component
namespace: cellular_component
def: "OBSOLETE. These are terms that have been removed from the active component ontology." [GOC:go_curators]
comment: This term was made obsolete because it is unnecessary in the OBO flat file format.
is_obsolete: true

[Term]
id: GO:0008371
name: obsolete biological process
namespace: biological_process
def: "OBSOLETE. These are terms that have been removed from the active process ontology." [GOC:go_curators]
comment: This term was made obsolete because it is unnecessary in the OBO flat file format.
is_obsolete: true

[Term]
id: GO:0008373
name: sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
xref: EC:2.4.99.-
xref: MetaCyc:2.4.99.10-RXN
is_a: GO:0016757 ! transferase activity, transferring glycosyl groups

[Term]
id: GO:0008374
name: O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
xref: Reactome:1150 "O-acyltransferase activity"
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0008375
name: acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to an oligosaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "GlcNAc transferase activity" EXACT []
xref: EC:2.4.1.-
xref: MetaCyc:2.4.1.223-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0008376
name: acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "GalNAc transferase activity" EXACT []
xref: EC:2.4.1.-
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0008377
name: light-induced release of internally sequestered calcium ion
namespace: biological_process
def: "The process by which the detection of light triggers the release of internally sequestered calcium ions." [GOC:ai]
synonym: "light-induced release of calcium from internal store" EXACT []
synonym: "light-induced release of internally sequestered calcium ion (Ca2+)" EXACT []
synonym: "light-induced release of internally stored calcium ion (Ca2+)" EXACT []
is_a: GO:0051283 ! negative regulation of sequestering of calcium ion
relationship: part_of GO:0009586 ! rhodopsin mediated phototransduction

[Term]
id: GO:0008378
name: galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: EC:2.4.1.-
xref: MetaCyc:2.4.1.151-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0008379
name: thioredoxin peroxidase activity
namespace: molecular_function
alt_id: GO:0009031
def: "Catalysis of the reaction: thioredoxin + H2O2 = thioredoxin disulfide + H2O." [MetaCyc:RXN0-267]
subset: gosubset_prok
synonym: "thiol peroxidase activity" EXACT []
synonym: "TPx activity" EXACT []
synonym: "TrxPx activity" EXACT []
xref: EC:1.11.1.-
xref: MetaCyc:RXN0-267
is_a: GO:0004601 ! peroxidase activity
is_a: GO:0051920 ! peroxiredoxin activity

[Term]
id: GO:0008380
name: RNA splicing
namespace: biological_process
alt_id: GO:0006395
def: "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah]
subset: gosubset_prok
synonym: "pre-mRNA splicing factor activity" RELATED []
xref: Wikipedia:RNA_splicing
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0008381
name: mechanically-gated ion channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005216 ! ion channel activity
is_a: GO:0022833 ! mechanically gated channel activity

[Term]
id: GO:0008384
name: IkappaB kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein." [EC:2.7.11.10]
comment: Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB. The kinase is composed of alpha, beta and gamma subunits, of which the latter does not have kinase activity but is presumed to play a regulatory role.
synonym: "ATP:IkappaB protein phosphotransferase activity" EXACT [EC:2.7.11.10]
synonym: "CHUK" RELATED [EC:2.7.11.10]
synonym: "ikappaB kinase activity" EXACT [EC:2.7.11.10]
synonym: "IKBKA" RELATED [EC:2.7.11.10]
synonym: "IKBKB" RELATED [EC:2.7.11.10]
synonym: "IKK" RELATED [EC:2.7.11.10]
synonym: "IKK-1" RELATED [EC:2.7.11.10]
synonym: "IKK-2" RELATED [EC:2.7.11.10]
synonym: "inhibitor of NF-kappaB kinase activity" EXACT [EC:2.7.11.10]
synonym: "inhibitor of NFkappaB kinase activity" EXACT [EC:2.7.11.10]
synonym: "STK12" RELATED [EC:2.7.11.10]
synonym: "TANK-binding kinase 1 activity" NARROW [EC:2.7.11.10]
synonym: "TBK1" RELATED [EC:2.7.11.10]
xref: EC:2.7.11.10
xref: MetaCyc:2.7.11.10-RXN
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0008385
name: IkappaB kinase complex
namespace: cellular_component
def: "A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role." [GOC:ma]
synonym: "IKK complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0008386
name: cholesterol monooxygenase (side-chain-cleaving) activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6]
synonym: "C27-side chain cleavage enzyme" RELATED [EC:1.14.15.6]
synonym: "cholesterol 20-22-desmolase activity" EXACT [EC:1.14.15.6]
synonym: "cholesterol C(20-22) desmolase activity" EXACT [EC:1.14.15.6]
synonym: "cholesterol C20-22 desmolase activity" EXACT [EC:1.14.15.6]
synonym: "cholesterol desmolase activity" EXACT [EC:1.14.15.6]
synonym: "cholesterol side-chain cleavage enzyme activity" RELATED [EC:1.14.15.6]
synonym: "cholesterol side-chain-cleaving enzyme activity" RELATED [EC:1.14.15.6]
synonym: "cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)" EXACT [EC:1.14.15.6]
synonym: "Cyp11a1" NARROW []
synonym: "cytochrome P-450(scc) activity" NARROW [EC:1.14.15.6]
synonym: "cytochrome P-450scc" RELATED [EC:1.14.15.6]
synonym: "cytochrome p450(scc) activity" NARROW [EC:1.14.15.6]
synonym: "cytochrome p450scc" RELATED [EC:1.14.15.6]
synonym: "desmolase, steroid 20-22" EXACT [EC:1.14.15.6]
synonym: "enzymes, cholesterol side-chain-cleaving" RELATED [EC:1.14.15.6]
synonym: "steroid 20-22 desmolase activity" BROAD [EC:1.14.15.6]
synonym: "steroid 20-22-lyase activity" BROAD [EC:1.14.15.6]
xref: EC:1.14.15.6
xref: MetaCyc:1.14.15.6-RXN
xref: Reactome:24219 "cholesterol monooxygenase (side-chain-cleaving) activity"
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0008387
name: steroid 7-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O." [GOC:mah]
synonym: "cytochrome P450 CYP2A12" NARROW []
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008388
name: testosterone 15-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O." [GOC:ai]
synonym: "cytochrome P450 CYP2A4" NARROW []
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008389
name: coumarin 7-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+." [Reactome:163103]
synonym: "cytochrome P450 CYP2A5" NARROW []
xref: Reactome:24222 "coumarin 7-hydroxylase activity"
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008390
name: testosterone 16-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-alpha-hydroxytestosterone + H2O." [GOC:ai]
synonym: "cytochrome P450 CYP2B10" NARROW []
synonym: "cytochrome P450 CYP2B9" NARROW []
synonym: "cytochrome P450 CYP2D10" NARROW []
synonym: "cytochrome P450 CYP2D11" NARROW []
synonym: "cytochrome P450 CYP2D9" NARROW []
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008391
name: arachidonic acid monooxygenase activity
namespace: molecular_function
synonym: "cytochrome P450 CYP2B19" NARROW []
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008392
name: arachidonic acid epoxygenase activity
namespace: molecular_function
def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399]
synonym: "cytochrome P450 CYP2J5" NARROW []
synonym: "cytochrome P450 CYP2J6" NARROW []
xref: Reactome:24235 "arachidonic acid epoxygenase activity"
is_a: GO:0008391 ! arachidonic acid monooxygenase activity

[Term]
id: GO:0008393
name: fatty acid (omega-1)-hydroxylase activity
namespace: molecular_function
synonym: "cytochrome P450 CYP2E1" NARROW []
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008394
name: olfactory-specific steroid hydroxylase activity
namespace: molecular_function
synonym: "cytochrome P450 CYP2G1" NARROW []
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008395
name: steroid hydroxylase activity
namespace: molecular_function
def: "Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
xref: Reactome:12240 "steroid hydroxylase activity"
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0008396
name: oxysterol 7-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O." [PMID:10882791]
synonym: "cytochrome P450 CYP7B1" NARROW []
xref: Reactome:24238 "oxysterol 7-alpha-hydroxylase activity"
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008397
name: sterol 12-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O." [GOC:mah]
synonym: "cytochrome P450 CYP8B1" NARROW []
xref: Reactome:24239 "sterol 12-alpha-hydroxylase activity"
is_a: GO:0008395 ! steroid hydroxylase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008398
name: sterol 14-demethylase activity
namespace: molecular_function
def: "Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O." [EC:1.14.13.70]
subset: gosubset_prok
synonym: "cytochrome P450 51 activity" NARROW [EC:1.14.13.70]
synonym: "cytochrome P450 CYP51" NARROW []
synonym: "lanosterol 14-alpha-demethylase activity" NARROW [EC:1.14.13.70]
synonym: "lanosterol 14-demethylase activity" NARROW [EC:1.14.13.70]
synonym: "lanosterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70]
synonym: "obtusufoliol 14-demethylase activity" NARROW [EC:1.14.13.70]
synonym: "sterol 14-alpha-demethylase activity" EXACT [EC:1.14.13.70]
synonym: "sterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70]
synonym: "sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving)" EXACT [EC:1.14.13.70]
xref: EC:1.14.13.70
xref: MetaCyc:1.14.13.70-RXN
xref: Reactome:24240 "sterol 14-demethylase activity"
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
is_a: GO:0032451 ! demethylase activity

[Term]
id: GO:0008399
name: naphthalene hydroxylase activity
namespace: molecular_function
synonym: "cytochrome P450 CYP2F2" NARROW []
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008401
name: retinoic acid 4-hydroxylase activity
namespace: molecular_function
synonym: "cytochrome P450 CYP261" NARROW []
xref: Reactome:24496 "retinoic acid 4-hydroxylase activity"
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008403
name: 25-hydroxycholecalciferol-24-hydroxylase activity
namespace: molecular_function
alt_id: GO:0030344
def: "Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol." [ISBN:0471331309 "Biochemical Pathways"]
synonym: "25-hydroxyvitamin D3 24-hydroxylase activity" EXACT []
synonym: "cytochrome P450 CYP24" NARROW []
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0070576 ! vitamin D 24-hydroxylase activity

[Term]
id: GO:0008404
name: arachidonic acid 14,15-epoxygenase activity
namespace: molecular_function
def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399]
synonym: "cytochrome P450 CYP2C29" NARROW []
synonym: "cytochrome P450 CYP2C39" NARROW []
is_a: GO:0008392 ! arachidonic acid epoxygenase activity

[Term]
id: GO:0008405
name: arachidonic acid 11,12-epoxygenase activity
namespace: molecular_function
def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399]
synonym: "cytochrome P450 CYP2C38" NARROW []
is_a: GO:0008392 ! arachidonic acid epoxygenase activity

[Term]
id: GO:0008406
name: gonad development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0048513 ! organ development
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0045137 ! development of primary sexual characteristics

[Term]
id: GO:0008407
name: bristle morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the bristle are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0022416 ! bristle development

[Term]
id: GO:0008408
name: 3'-5' exonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai]
subset: gosubset_prok
synonym: "3'-5'-exonuclease activity" EXACT []
is_a: GO:0004527 ! exonuclease activity

[Term]
id: GO:0008409
name: 5'-3' exonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end." [GOC:ai]
subset: gosubset_prok
is_a: GO:0004527 ! exonuclease activity

[Term]
id: GO:0008410
name: CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)." [GOC:jl]
subset: gosubset_prok
xref: EC:2.8.3.-
is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups

[Term]
id: GO:0008411
name: 4-hydroxybutyrate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate." [GOC:jl]
subset: gosubset_prok
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0008412
name: 4-hydroxybenzoate octaprenyltransferase activity
namespace: molecular_function
alt_id: GO:0000043
alt_id: GO:0048043
alt_id: GO:0048044
def: "Catalysis of the reaction: farnesylfarnesylgeranyl-PP + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate." [MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN]
subset: gosubset_prok
synonym: "4-HB polyprenyltransferase activity" EXACT []
synonym: "para-hydroxybenzoate transferase activity" EXACT []
synonym: "para-hydroxybenzoate-polyprenyl diphosphate transferase activity" EXACT []
synonym: "para-hydroxybenzoate:polyprenyltransferase activity" EXACT []
synonym: "PHB polyprenyl diphosphate transferase activity" EXACT []
xref: EC:2.5.1.-
xref: MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN
is_a: GO:0002094 ! polyprenyltransferase activity

[Term]
id: GO:0008413
name: 8-oxo-7,8-dihydroguanine triphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-oxo-7,8-dihydroguanine triphosphate = 8-oxo-7,8-dihydroguanine phosphate + diphosphate." [PMID:7782328]
subset: gosubset_prok
synonym: "7,8-dihydro-8-oxoguanine-triphosphatase activity" EXACT []
synonym: "8-oxo-GTPase activity" EXACT []
xref: EC:3.6.1.-
is_a: GO:0017111 ! nucleoside-triphosphatase activity

[Term]
id: GO:0008414
name: CDP-alcohol phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a CDP-alcohol group from one compound to another." [GOC:jl]
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0008415
name: acyltransferase activity
namespace: molecular_function
def: "Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier." [EC:2.3.1.-, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: EC:2.3.1.-
xref: Reactome:1091 "acyltransferase activity"
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0008416
name: delta5-delta2,4-dienoyl-CoA isomerase activity
namespace: molecular_function
xref: EC:5.3.3.-
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0008417
name: fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
subset: gosubset_prok
xref: EC:2.4.1.-
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0008418
name: protein N-terminal asparagine amidohydrolase activity
namespace: molecular_function
xref: EC:3.5.1.-
is_a: GO:0004067 ! asparaginase activity

[Term]
id: GO:0008419
name: RNA lariat debranching enzyme activity
namespace: molecular_function
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008420
name: CTD phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate." [EC:3.1.3.16]
is_a: GO:0004722 ! protein serine/threonine phosphatase activity

[Term]
id: GO:0008421
name: long-chain-fatty-acyl-glutamate deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate." [EC:3.5.1.55]
synonym: "long-chain acylglutamate amidase activity" EXACT [EC:3.5.1.55]
synonym: "long-chain aminoacylase activity" EXACT [EC:3.5.1.55]
synonym: "N-long-chain-fatty-acyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.55]
xref: EC:3.5.1.55
xref: MetaCyc:3.5.1.55-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008422
name: beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21]
subset: gosubset_prok
synonym: "amygdalase activity" NARROW [EC:3.2.1.21]
synonym: "amygdalinase" BROAD [EC:3.2.1.21]
synonym: "arbutinase activity" EXACT [EC:3.2.1.21]
synonym: "aryl-beta-glucosidase activity" EXACT [EC:3.2.1.21]
synonym: "beta-1,6-glucosidase activity" EXACT [EC:3.2.1.21]
synonym: "beta-D-glucosidase activity" EXACT [EC:3.2.1.21]
synonym: "beta-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21]
synonym: "beta-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21]
synonym: "cellobiase activity" NARROW [EC:3.2.1.21]
synonym: "elaterase activity" NARROW [EC:3.2.1.21]
synonym: "emulsin" RELATED [EC:3.2.1.21]
synonym: "gentiobiase activity" NARROW [EC:3.2.1.21]
synonym: "gentobiase activity" NARROW [EC:3.2.1.21]
synonym: "limarase activity" NARROW [EC:3.2.1.21]
synonym: "p-nitrophenyl beta-glucosidase activity" EXACT [EC:3.2.1.21]
synonym: "primeverosidase activity" NARROW [EC:3.2.1.21]
synonym: "salicilinase activity" NARROW [EC:3.2.1.21]
xref: EC:3.2.1.21
xref: MetaCyc:3.2.1.21-RXN
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0008423
name: bleomycin hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred." [EC:3.4.22.40]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "aminopeptidase C (Lactococcus lactis)" NARROW [EC:3.4.22.40]
xref: EC:3.4.22.40
xref: MetaCyc:3.4.22.40-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0008424
name: glycoprotein 6-alpha-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-fucose + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine = GDP + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine." [EC:2.4.1.68]
synonym: "FucT" RELATED [EC:2.4.1.68]
synonym: "GDP-fucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68]
synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase activity" EXACT [EC:2.4.1.68]
synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1->6)fucosyltransferase activity" EXACT [EC:2.4.1.68]
synonym: "GDP-L-fucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68]
synonym: "GDPfucose-glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68]
synonym: "glycoprotein fucosyltransferase activity" BROAD [EC:2.4.1.68]
synonym: "guanosine diphosphofucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68]
xref: EC:2.4.1.68
xref: MetaCyc:2.4.1.68-RXN
is_a: GO:0046921 ! alpha(1,6)-fucosyltransferase activity

[Term]
id: GO:0008425
name: 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048]
subset: gosubset_prok
synonym: "2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
synonym: "coenzyme Q biosynthesis methyltransferase activity" EXACT []
synonym: "coenzyme Q biosynthetic process methyltransferase activity" EXACT []
synonym: "ubiquinone biosynthesis methyltransferase activity" BROAD []
synonym: "ubiquinone biosynthetic process methyltransferase activity" BROAD []
xref: EC:2.1.1.-
is_a: GO:0030580 ! quinone cofactor methyltransferase activity

[Term]
id: GO:0008426
name: protein kinase C inhibitor activity
namespace: molecular_function
alt_id: GO:0004863
def: "Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein." [GOC:ai]
synonym: "diacylglycerol-activated phospholipid-dependent PKC inhibitor activity" EXACT []
synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity" EXACT []
synonym: "PKC inhibitor activity" EXACT []
is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity

[Term]
id: GO:0008427
name: calcium-dependent protein kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a calcium-dependent protein kinase." [GOC:mah]
is_a: GO:0004860 ! protein kinase inhibitor activity
is_a: GO:0010858 ! calcium-dependent protein kinase regulator activity

[Term]
id: GO:0008428
name: ribonuclease inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:ai]
subset: gosubset_prok
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0008429
name: phosphatidylethanolamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0005543 ! phospholipid binding

[Term]
id: GO:0008430
name: selenium binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with selenium (Se)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0008431
name: vitamin E binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "alpha-tocopherol binding" NARROW []
synonym: "tocopherol binding" EXACT []
is_a: GO:0019842 ! vitamin binding

[Term]
id: GO:0008432
name: JUN kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family." [GOC:jl]
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0008434
name: vitamin D3 receptor activity
namespace: molecular_function
def: "Combining with vitamin D3, cholecalciferol, to initiate a change in cell activity." [GOC:ai]
comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'.
synonym: "cholecaliferol receptor activity" EXACT []
is_a: GO:0004879 ! ligand-dependent nuclear receptor activity

[Term]
id: GO:0008435
name: anticoagulant activity
namespace: molecular_function
def: "OBSOLETE. Functions to retard or prevent coagulation. Often used in the context of blood or milk coagulation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a biological process.
is_obsolete: true
replaced_by: GO:0050819

[Term]
id: GO:0008436
name: heterogeneous nuclear ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
synonym: "hnRNP" EXACT []
is_obsolete: true
replaced_by: GO:0030530

[Term]
id: GO:0008437
name: thyrotropin-releasing hormone activity
namespace: molecular_function
def: "The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "TRH activity" EXACT [ISBN:0198506732]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0008438
name: 1-phosphatidylinositol-5-phosphate kinase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: diphosphate + a purine nucleoside = phosphate + a purine mononucleotide." [EC:2.7.1.143]
comment: This term was made obsolete because it is a redundant grouping term with only one child. It is also incorrectly defined and had an incorrect EC dbxref.
is_obsolete: true
consider: GO:0016309

[Term]
id: GO:0008439
name: monophenol monooxygenase activator activity
namespace: molecular_function
def: "OBSOLETE. Increases the activity of the enzyme monophenol monooxygenase." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "prophenol oxidase activator" RELATED []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008440
name: inositol trisphosphate 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate." [EC:2.7.1.127]
synonym: "1D-myo-inositol-trisphosphate 3-kinase activity" EXACT []
synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.127]
synonym: "inositol 1,4,5-trisphosphate 3-kinase activity" EXACT []
synonym: "inositol-trisphosphate 3-kinase activity" EXACT []
synonym: "ins(1,4,5)P(3) 3-kinase activity" EXACT [EC:2.7.1.127]
synonym: "Ins(1,4,5)P3 3-kinase activity" EXACT [EC:2.7.1.127]
synonym: "IP3 3-kinase activity" NARROW [EC:2.7.1.127]
synonym: "IP3K activity" NARROW [EC:2.7.1.127]
xref: EC:2.7.1.127
xref: MetaCyc:2.7.1.127-RXN
is_a: GO:0051766 ! inositol trisphosphate kinase activity

[Term]
id: GO:0008441
name: 3'(2'),5'-bisphosphate nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate." [EC:3.1.3.7]
subset: gosubset_prok
synonym: "3'(2'),5' bisphosphate nucleotidase activity" EXACT []
synonym: "3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase activity" EXACT [EC:3.1.3.7]
synonym: "3'-phosphoadenylylsulfate 3'-phosphatase activity" EXACT [EC:3.1.3.7]
synonym: "adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase activity" EXACT [EC:3.1.3.7]
synonym: "DPNPase activity" EXACT [EC:3.1.3.7]
synonym: "phosphoadenylate 3'-nucleotidase activity" EXACT [EC:3.1.3.7]
xref: EC:3.1.3.7
xref: MetaCyc:325-BISPHOSPHATE-NUCLEOTIDASE-RXN
xref: Reactome:24620 "3'(2'),5'-bisphosphate nucleotidase activity"
is_a: GO:0008252 ! nucleotidase activity

[Term]
id: GO:0008442
name: 3-hydroxyisobutyrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+." [EC:1.1.1.31]
subset: gosubset_prok
xref: EC:1.1.1.31
xref: MetaCyc:3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN
xref: Reactome:24621 "3-hydroxyisobutyrate dehydrogenase activity"
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008443
name: phosphofructokinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a fructose substrate molecule." [GOC:jl]
subset: gosubset_prok
xref: EC:2.7.1.-
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008444
name: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-diacylglycerol + glycerol 3-phosphate = CMP + 3-(3-phosphatidyl)-glycerol 1-phosphate." [EC:2.7.8.5]
subset: gosubset_prok
synonym: "3-phosphatidyl-1'-glycerol-3'-phosphate synthase activity" EXACT [EC:2.7.8.5]
synonym: "CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "glycerol 3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "glycerol phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "glycerophosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
synonym: "PGP synthase activity" EXACT [EC:2.7.8.5]
synonym: "phosphatidylglycerol phosphate synthase activity" EXACT [EC:2.7.8.5]
synonym: "phosphatidylglycerol phosphate synthetase activity" EXACT [EC:2.7.8.5]
synonym: "phosphatidylglycerolphosphate synthase activity" EXACT [EC:2.7.8.5]
synonym: "phosphatidylglycerophosphate synthase activity" EXACT [EC:2.7.8.5]
synonym: "phosphatidylglycerophosphate synthetase activity" EXACT [EC:2.7.8.5]
synonym: "sn-glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5]
xref: EC:2.7.8.5
xref: MetaCyc:PHOSPHAGLYPSYN-RXN
is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity

[Term]
id: GO:0008445
name: D-aspartate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2." [EC:1.4.3.1]
synonym: "aspartic oxidase activity" EXACT [EC:1.4.3.1]
synonym: "D-aspartate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.1]
synonym: "D-aspartic oxidase activity" EXACT [EC:1.4.3.1]
xref: EC:1.4.3.1
xref: MetaCyc:D-ASPARTATE-OXIDASE-RXN
is_a: GO:0015922 ! aspartate oxidase activity

[Term]
id: GO:0008446
name: GDP-mannose 4,6-dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O." [EC:4.2.1.47]
subset: gosubset_prok
synonym: "GDP-D-mannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47]
synonym: "GDP-D-mannose dehydratase activity" EXACT [EC:4.2.1.47]
synonym: "GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)" EXACT [EC:4.2.1.47]
synonym: "GDP-mannose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.47]
synonym: "GDPmannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47]
synonym: "Gmd" RELATED [EC:4.2.1.47]
synonym: "guanosine 5'-diphosphate-D-mannose oxidoreductase activity" EXACT [EC:4.2.1.47]
synonym: "guanosine diphosphomannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47]
synonym: "guanosine diphosphomannose oxidoreductase activity" EXACT [EC:4.2.1.47]
xref: EC:4.2.1.47
xref: MetaCyc:GDPMANDEHYDRA-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008447
name: L-ascorbate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O." [EC:1.10.3.3]
synonym: "AA oxidase activity" EXACT [EC:1.10.3.3]
synonym: "AAO" RELATED [EC:1.10.3.3]
synonym: "ascorbase activity" EXACT [EC:1.10.3.3]
synonym: "ascorbate dehydrogenase activity" EXACT [EC:1.10.3.3]
synonym: "ascorbate oxidase activity" EXACT [EC:1.10.3.3]
synonym: "ascorbic acid oxidase activity" EXACT [EC:1.10.3.3]
synonym: "ascorbic oxidase activity" EXACT [EC:1.10.3.3]
synonym: "L-ascorbate:O2 oxidoreductase activity" EXACT [EC:1.10.3.3]
synonym: "L-ascorbate:oxygen oxidoreductase activity" EXACT [EC:1.10.3.3]
synonym: "L-ascorbic acid oxidase activity" EXACT [EC:1.10.3.3]
xref: EC:1.10.3.3
xref: MetaCyc:L-ASCORBATE-OXIDASE-RXN
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0008448
name: N-acetylglucosamine-6-phosphate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate." [EC:3.5.1.25]
subset: gosubset_prok
synonym: "2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase activity" EXACT [EC:3.5.1.25]
synonym: "acetylaminodeoxyglucosephosphate acetylhydrolase activity" EXACT [EC:3.5.1.25]
synonym: "acetylglucosamine phosphate deacetylase activity" EXACT [EC:3.5.1.25]
synonym: "N-acetyl-D-glucosamine-6-phosphate amidohydrolase activity" EXACT [EC:3.5.1.25]
xref: EC:3.5.1.25
xref: MetaCyc:NAG6PDEACET-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0008449
name: N-acetylglucosamine-6-sulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14]
subset: gosubset_prok
synonym: "2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity" EXACT [EC:3.1.6.14]
synonym: "acetylglucosamine 6-sulfatase activity" EXACT [EC:3.1.6.14]
synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.14]
synonym: "glucosamine-6-sulfatase activity" EXACT [EC:3.1.6.14]
synonym: "N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase activity" EXACT [EC:3.1.6.14]
synonym: "N-acetylglucosamine 6-sulfate sulfatase activity" EXACT [EC:3.1.6.14]
synonym: "N-acetylglucosamine-6-sulphatase activity" EXACT []
synonym: "O,N-disulfate O-sulfohydrolase activity" EXACT [EC:3.1.6.14]
xref: EC:3.1.6.14
xref: MetaCyc:3.1.6.14-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0008450
name: O-sialoglycoprotein endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated." [EC:3.4.24.57]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "glycophorin A proteinase activity" EXACT [EC:3.4.24.57]
synonym: "glycoprotease activity" RELATED [EC:3.4.24.57]
synonym: "glycoproteinase activity" EXACT [EC:3.4.24.57]
synonym: "sialoglycoprotease activity" EXACT [EC:3.4.24.57]
synonym: "sialoglycoproteinase activity" EXACT [EC:3.4.24.57]
xref: EC:3.4.24.57
xref: MetaCyc:3.4.24.57-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008451
name: X-Pro aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide." [EC:3.4.11.9]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "aminoacylproline aminopeptidase activity" EXACT [EC:3.4.11.9]
synonym: "aminopeptidase P" EXACT []
synonym: "proline aminopeptidase" BROAD [EC:3.4.11.9]
synonym: "Xaa-Pro aminopeptidase activity" EXACT []
xref: EC:3.4.11.9
xref: MetaCyc:3.4.11.9-RXN
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0008452
name: RNA ligase activity
namespace: molecular_function
def: "Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5'-phosphate group at the end of another." [GOC:mah]
subset: gosubset_prok
xref: EC:6.5.1.-
is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds

[Term]
id: GO:0008453
name: alanine-glyoxylate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine." [EC:2.6.1.44]
subset: gosubset_prok
synonym: "AGT activity" EXACT [EC:2.6.1.44]
synonym: "alanine--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.44]
synonym: "alanine-glyoxylate aminotransferase activity" EXACT []
synonym: "alanine-glyoxylic aminotransferase activity" EXACT [EC:2.6.1.44]
synonym: "L-alanine-glycine transaminase activity" EXACT [EC:2.6.1.44]
synonym: "L-alanine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.44]
xref: EC:2.6.1.44
xref: MetaCyc:ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN
xref: Reactome:24651 "alanine-glyoxylate transaminase activity"
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0008454
name: alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R." [EC:2.4.1.145]
synonym: "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.145]
synonym: "alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "beta-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145]
synonym: "GnTIV activity" EXACT [EC:2.4.1.145]
synonym: "N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145]
synonym: "UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.145]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV" RELATED [EC:2.4.1.145]
xref: EC:2.4.1.145
xref: MetaCyc:2.4.1.145-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0008455
name: alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R." [EC:2.4.1.143]
synonym: "acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143]
synonym: "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "GnTII activity" EXACT [EC:2.4.1.143]
synonym: "N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143]
synonym: "UDP-GlcNAc:mannoside alpha-1-6 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "UDP-GlcNAc:mannoside alpha1-6 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1-2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1-2-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta1-2-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "uridine diphosphoacetylglucosamine-mannoside alpha-1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
synonym: "uridine diphosphoacetylglucosamine-mannoside alpha1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143]
xref: EC:2.4.1.143
xref: MetaCyc:2.4.1.143-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0008456
name: alpha-N-acetylgalactosaminidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides." [EC:3.2.1.49]
synonym: "alpha-acetylgalactosaminidase activity" EXACT [EC:3.2.1.49]
synonym: "alpha-galactosidase B activity" RELATED [EC:3.2.1.49]
synonym: "alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity" EXACT [EC:3.2.1.49]
synonym: "alpha-NAGA activity" EXACT [EC:3.2.1.49]
synonym: "N-acetyl-alpha-D-galactosaminidase activity" EXACT [EC:3.2.1.49]
synonym: "N-acetyl-alpha-galactosaminidase activity" EXACT [EC:3.2.1.49]
xref: EC:3.2.1.49
xref: MetaCyc:3.2.1.49-RXN
is_a: GO:0015929 ! hexosaminidase activity

[Term]
id: GO:0008457
name: beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide." [EC:2.4.1.163]
synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.163]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.163]
synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.163]
xref: EC:2.4.1.163
xref: MetaCyc:2.4.1.163-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0008458
name: carnitine O-octanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine." [EC:2.3.1.137]
synonym: "carnitine medium-chain acyltransferase activity" EXACT [EC:2.3.1.137]
synonym: "easily solubilized mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137]
synonym: "medium-chain/long-chain carnitine acyltransferase activity" EXACT [EC:2.3.1.137]
synonym: "octanoyl-CoA:L-carnitine O-octanoyltransferase activity" EXACT [EC:2.3.1.137]
synonym: "overt mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137]
xref: EC:2.3.1.137
xref: MetaCyc:CARNITINE-O-OCTANOYLTRANSFERASE-RXN
xref: Reactome:24659 "carnitine O-octanoyltransferase activity"
is_a: GO:0016406 ! carnitine O-acyltransferase activity
is_a: GO:0016414 ! O-octanoyltransferase activity

[Term]
id: GO:0008459
name: chondroitin 6-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.17]
synonym: "3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase activity" EXACT [EC:2.8.2.17]
synonym: "3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase activity" EXACT [EC:2.8.2.17]
synonym: "chondroitin 6-O-sulfotransferase activity" EXACT [EC:2.8.2.17]
synonym: "chondroitin 6-sulphotransferase activity" EXACT []
synonym: "terminal 6-sulfotransferase activity" EXACT [EC:2.8.2.17]
xref: EC:2.8.2.17
xref: MetaCyc:CHONDROITIN-6-SULFOTRANSFERASE-RXN
is_a: GO:0034481 ! chondroitin sulfotransferase activity

[Term]
id: GO:0008460
name: dTDP-glucose 4,6-dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-D-glucose + H2O." [EC:4.2.1.46]
subset: gosubset_prok
synonym: "dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.46]
synonym: "dTDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.46]
synonym: "dTDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.46]
synonym: "dTDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.46]
synonym: "TDP-glucose oxidoreductase activity" EXACT [EC:4.2.1.46]
synonym: "thymidine diphosphoglucose oxidoreductase activity" EXACT [EC:4.2.1.46]
xref: EC:4.2.1.46
xref: MetaCyc:DTDPGLUCDEHYDRAT-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008462
name: endopeptidase Clp activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs)." [EC:3.4.21.92]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "ATP-dependent Clp protease" NARROW [EC:3.4.21.92]
synonym: "caseinolytic protease activity" RELATED [EC:3.4.21.92]
synonym: "Clp protease" NARROW [EC:3.4.21.92]
synonym: "ClpP" RELATED [EC:3.4.21.92]
synonym: "endopeptidase Ti activity" RELATED [EC:3.4.21.92]
synonym: "protease Ti activity" RELATED [EC:3.4.21.92]
xref: EC:3.4.21.92
xref: MetaCyc:3.4.21.92-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008463
name: formylmethionine deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formyl-L-methionine + H2O = formate + L-methionine." [EC:3.5.1.31]
subset: gosubset_prok
synonym: "N-formyl-L-methionine amidohydrolase activity" EXACT [EC:3.5.1.31]
xref: EC:3.5.1.31
xref: MetaCyc:FORMYLMETHIONINE-DEFORMYLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008464
name: gamma-glutamyl hydrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid." [EC:3.4.19.9]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase G activity" BROAD [EC:3.4.19.9]
synonym: "conjugase activity" RELATED [EC:3.4.19.9]
synonym: "folate conjugase activity" RELATED [EC:3.4.19.9]
synonym: "folic acid conjugase activity" EXACT [EC:3.4.19.9]
synonym: "gamma-Glu-X carboxypeptidase activity" EXACT [EC:3.4.19.9]
synonym: "lysosomal gamma-glutamyl carboxypeptidase activity" NARROW [EC:3.4.19.9]
synonym: "poly(gamma-glutamic acid) endohydrolase activity" EXACT [EC:3.4.19.9]
synonym: "poly(glutamic acid) hydrolase II" RELATED [EC:3.4.19.9]
synonym: "polyglutamate hydrolase activity" EXACT [EC:3.4.19.9]
synonym: "pteroyl-poly-alpha-glutamate hydrolase activity" NARROW [EC:3.4.19.9]
synonym: "pteroyl-poly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.19.9]
synonym: "pteroylpoly-gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9]
xref: EC:3.4.19.9
xref: MetaCyc:3.4.19.9-RXN
is_obsolete: true
replaced_by: GO:0008242

[Term]
id: GO:0008465
name: glycerate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+." [EC:1.1.1.29]
subset: gosubset_prok
synonym: "hydroxypyruvate dehydrogenase activity" BROAD [EC:1.1.1.29]
xref: EC:1.1.1.29
xref: MetaCyc:GLYCERATE-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008466
name: glycogenin glucosyltransferase activity
namespace: molecular_function
alt_id: GO:0047210
def: "Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin." [EC:2.4.1.186]
synonym: "1,4alpha-glucan-protein synthase (UDP-forming) activity" EXACT []
synonym: "alpha-1,4-glucan-protein synthase (UDP-forming) activity" EXACT []
synonym: "glycogenin activity" RELATED [EC:2.4.1.186]
synonym: "priming glucosyltransferase activity" RELATED [EC:2.4.1.186]
synonym: "UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.186]
synonym: "UDP-glucose:glycogenin glucosyltransferase activity" EXACT [EC:2.4.1.186]
xref: EC:2.4.1.186
xref: MetaCyc:GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN
xref: Reactome:24685 "glycogenin glucosyltransferase activity"
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0008467
name: [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate, with a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S." [EC:2.8.2.23]
synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase" BROAD [EC:2.8.2.23]
synonym: "3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23]
synonym: "3-OST-1 activity" EXACT [EC:2.8.2.23]
synonym: "glucosaminyl 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23]
synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23]
synonym: "heparin-glucosamine 3-O-sulfotransferase activity" RELATED []
synonym: "heparin-glucosamine 3-O-sulphotransferase activity" RELATED []
synonym: "isoform/isozyme 1 (3-OST-1, HS3ST1)" RELATED [EC:2.8.2.23]
xref: EC:2.8.2.23
xref: MetaCyc:2.8.2.23-RXN
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0008469
name: histone-arginine N-methyltransferase activity
namespace: molecular_function
alt_id: GO:0016276
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone-arginine = S-adenosyl-L-homocysteine + histone-N-methyl-arginine." [EC:2.1.1.125]
synonym: "histone methyltransferase activity" BROAD []
synonym: "histone protein methylase activity" EXACT [EC:2.1.1.125]
synonym: "histone protein methylase I" RELATED [EC:2.1.1.125]
synonym: "histone-arginine N-methylase activity" EXACT [GOC:mah]
synonym: "nuclear protein (histone) N-methyltransferase activity" EXACT [EC:2.1.1.125]
synonym: "protein methylase I activity" BROAD [EC:2.1.1.125]
synonym: "S-adenosyl-L-methionine:histone-arginine nomega-methyltransferase activity" EXACT [EC:2.1.1.125]
synonym: "S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase activity" EXACT [EC:2.1.1.125]
xref: EC:2.1.1.125
xref: MetaCyc:2.1.1.125-RXN
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity
is_a: GO:0042054 ! histone methyltransferase activity

[Term]
id: GO:0008470
name: isovaleryl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF." [EC:1.3.99.10]
subset: gosubset_prok
synonym: "3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.10]
synonym: "3-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.10]
synonym: "isovaleroyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.10]
synonym: "isovaleryl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.10]
xref: EC:1.3.99.10
xref: MetaCyc:ISOVALERYL-COA-FAD-RXN
xref: Reactome:24705 "isovaleryl-CoA dehydrogenase activity"
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0008471
name: laccase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O." [EC:1.10.3.2]
subset: gosubset_prok
synonym: "benzenediol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.2]
synonym: "p-diphenol oxidase activity" EXACT [EC:1.10.3.2]
synonym: "urishiol oxidase activity" RELATED [EC:1.10.3.2]
synonym: "urushiol oxidase activity" EXACT [EC:1.10.3.2]
xref: EC:1.10.3.2
xref: MetaCyc:LACCASE-RXN
xref: UM-BBD_enzymeID:e0629
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0008472
name: metallocarboxypeptidase D activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid." [EC:3.4.17.22]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase D (cattle, human, mouse, rat)" RELATED [EC:3.4.17.22]
synonym: "gp180 (duck)" RELATED [EC:3.4.17.22]
xref: EC:3.4.17.22
xref: MetaCyc:3.4.17.22-RXN
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0008473
name: ornithine cyclodeaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine = L-proline + NH3." [EC:4.3.1.12]
subset: gosubset_prok
synonym: "L-ornithine ammonia-lyase (cyclizing)" EXACT [EC:4.3.1.12]
synonym: "L-ornithine ammonia-lyase (cyclizing; L-proline-forming)" EXACT [EC:4.3.1.12]
synonym: "OCD activity" EXACT [EC:4.3.1.12]
synonym: "ornithine cyclase (deaminating) activity" EXACT [EC:4.3.1.12]
synonym: "ornithine cyclase activity" EXACT [EC:4.3.1.12]
xref: EC:4.3.1.12
xref: MetaCyc:ORNITHINE-CYCLODEAMINASE-RXN
is_a: GO:0016841 ! ammonia-lyase activity
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0008474
name: palmitoyl-(protein) hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22]
synonym: "palmitoyl-[protein] hydrolase" BROAD [EC:3.1.2.22]
synonym: "palmitoyl-protein hydrolase activity" EXACT []
synonym: "palmitoyl-protein thioesterase activity" EXACT []
synonym: "palmitoyl-protein thiolesterase activity" EXACT []
xref: EC:3.1.2.22
xref: MetaCyc:3.1.2.22-RXN
xref: Reactome:24711 "palmitoyl-(protein) hydrolase activity"
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0008475
name: procollagen-lysine 5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2." [EC:1.14.11.4]
synonym: "collagen lysine hydroxylase activity" EXACT [EC:1.14.11.4]
synonym: "lysine hydroxylase activity" BROAD [EC:1.14.11.4]
synonym: "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD [EC:1.14.11.4]
synonym: "lysine-2-oxoglutarate dioxygenase activity" BROAD [EC:1.14.11.4]
synonym: "lysyl hydroxylase activity" BROAD [EC:1.14.11.4]
synonym: "lysylprotocollagen dioxygenase activity" EXACT [EC:1.14.11.4]
synonym: "procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.11.4]
synonym: "procollagen-lysine,2-oxoglutarate 5-dioxygenase activity" EXACT [EC:1.14.11.4]
synonym: "protocollagen lysine dioxygenase activity" EXACT [EC:1.14.11.4]
synonym: "protocollagen lysine hydroxylase activity" EXACT [EC:1.14.11.4]
synonym: "protocollagen lysyl hydroxylase activity" EXACT [EC:1.14.11.4]
xref: EC:1.14.11.4
xref: MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN
is_a: GO:0070815 ! peptidyl-lysine 5-dioxygenase activity

[Term]
id: GO:0008476
name: protein-tyrosine sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20]
synonym: "3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity" EXACT [EC:2.8.2.20]
synonym: "protein-tyrosine sulphotransferase activity" EXACT []
synonym: "tyrosylprotein sulfotransferase activity" EXACT [EC:2.8.2.20]
xref: EC:2.8.2.20
xref: MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0008477
name: purine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose." [EC:3.2.2.1]
subset: gosubset_prok
synonym: "IAG-NH activity" RELATED [EC:3.2.2.1]
synonym: "IAG-nucleoside hydrolase activity" RELATED [EC:3.2.2.1]
synonym: "inosine-adenosine-guanosine preferring nucleoside hydrolase activity" NARROW [EC:3.2.2.1]
synonym: "N-D-ribosylpurine ribohydrolase activity" EXACT [EC:3.2.2.1]
synonym: "N-ribosyl purine ribohydrolase activity" EXACT [EC:3.2.2.1]
synonym: "nucleosidase activity" BROAD [EC:3.2.2.1]
synonym: "nucleosidase g activity" NARROW [EC:3.2.2.1]
synonym: "nucleoside hydrolase activity" BROAD [EC:3.2.2.1]
synonym: "purine beta-ribosidase activity" EXACT [EC:3.2.2.1]
synonym: "purine nucleosidase reaction" EXACT []
synonym: "purine nucleoside hydrolase activity" EXACT [EC:3.2.2.1]
synonym: "purine ribonucleosidase activity" EXACT [EC:3.2.2.1]
synonym: "purine-nucleoside ribohydrolase activity" EXACT [EC:3.2.2.1]
synonym: "purine-specific nucleoside N-ribohydrolase activity" EXACT [EC:3.2.2.1]
synonym: "ribonucleoside hydrolase activity" EXACT [EC:3.2.2.1]
xref: EC:3.2.2.1
xref: MetaCyc:PURINE-NUCLEOSIDASE-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0008478
name: pyridoxal kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate." [EC:2.7.1.35]
subset: gosubset_prok
synonym: "ATP:pyridoxal 5'-phosphotransferase activity" EXACT [EC:2.7.1.35]
synonym: "pyridoxal 5-phosphate-kinase activity" EXACT [EC:2.7.1.35]
synonym: "pyridoxal kinase (phosphorylating)" EXACT [EC:2.7.1.35]
synonym: "pyridoxal phosphokinase activity" EXACT [EC:2.7.1.35]
synonym: "pyridoxamine kinase activity" RELATED [EC:2.7.1.35]
synonym: "pyridoxine kinase activity" RELATED [EC:2.7.1.35]
synonym: "vitamin B(6) kinase activity" RELATED [EC:2.7.1.35]
synonym: "vitamin B6 kinase activity" RELATED [EC:2.7.1.35]
xref: EC:2.7.1.35
xref: MetaCyc:PYRIDOXKIN-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008479
name: queuine tRNA-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine." [EC:2.4.2.29]
subset: gosubset_prok
synonym: "[tRNA]-guanine:queuine tRNA-D-ribosyltransferase activity" EXACT [EC:2.4.2.29]
synonym: "guanine insertion enzyme activity" RELATED [EC:2.4.2.29]
synonym: "guanine, queuine-tRNA transglycosylase activity" EXACT [EC:2.4.2.29]
synonym: "Q-insertase activity" EXACT [EC:2.4.2.29]
synonym: "queuine transfer ribonucleate ribosyltransferase activity" EXACT [EC:2.4.2.29]
synonym: "transfer ribonucleate glycosyltransferase activity" EXACT [EC:2.4.2.29]
synonym: "tRNA guanine transglycosidase activity" EXACT [EC:2.4.2.29]
synonym: "tRNA transglycosylase activity" EXACT [EC:2.4.2.29]
synonym: "tRNA-guanine transglycosylase activity" EXACT [EC:2.4.2.29]
xref: EC:2.4.2.29
xref: MetaCyc:QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0008480
name: sarcosine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sarcosine + acceptor + H2O = glycine + formaldehyde + reduced acceptor." [EC:1.5.99.1]
subset: gosubset_prok
synonym: "monomethylglycine dehydrogenase activity" EXACT [EC:1.5.99.1]
synonym: "sarcosine N-demethylase activity" EXACT [EC:1.5.99.1]
synonym: "sarcosine:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.99.1]
synonym: "sarcosine:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.99.1]
xref: EC:1.5.99.1
xref: MetaCyc:SARCOSINE-DEHYDROGENASE-RXN
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0008481
name: sphinganine kinase activity
namespace: molecular_function
alt_id: GO:0001728
def: "Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate." [EC:2.7.1.91]
synonym: "ATP:sphinganine 1-phosphotransferase activity" EXACT [EC:2.7.1.91]
synonym: "dihydrosphingosine kinase (phosphorylating)" EXACT [EC:2.7.1.91]
synonym: "dihydrosphingosine kinase activity" EXACT [EC:2.7.1.91]
synonym: "sphingosine kinase (phosphorylating)" EXACT [EC:2.7.1.91]
synonym: "sphingosine kinase activity" RELATED []
xref: EC:2.7.1.91
xref: MetaCyc:SPHINGANINE-KINASE-RXN
is_a: GO:0001727 ! lipid kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008482
name: sulfite oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: SO3(2-) (sulfite) + O2 + H2O = SO4(2-) (sulfate) + H2O2." [EC:1.8.3.1]
subset: gosubset_prok
synonym: "sulfite:oxygen oxidoreductase activity" EXACT [EC:1.8.3.1]
synonym: "sulphite oxidase activity" EXACT []
xref: EC:1.8.3.1
xref: MetaCyc:PWY-5326
xref: MetaCyc:SULFITE-OXIDASE-RXN
is_a: GO:0016670 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0008483
name: transaminase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aminotransferase activity" EXACT []
xref: EC:2.6.1
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups

[Term]
id: GO:0008484
name: sulfuric ester hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai]
subset: gosubset_prok
synonym: "sulfatase activity" EXACT []
synonym: "sulphuric ester hydrolase activity" EXACT []
xref: EC:3.1.6
xref: MetaCyc:ARYLSULFAT-RXN
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0008486
name: diphosphoinositol-polyphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate." [EC:3.6.1.52]
synonym: "diphospho-myo-inositol-polyphosphate diphosphohydrolase activity" EXACT [EC:3.6.1.52e]
synonym: "diphosphoinositol polyphosphate phosphohydrolase activity" EXACT []
synonym: "diphosphoinositol-polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.52e]
synonym: "DIPP activity" EXACT [EC:3.6.1.52e]
xref: EC:3.6.1.52
xref: MetaCyc:3.6.1.52-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0008487
name: prenyl-dependent CAAX protease activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008488
name: gamma-glutamyl carboxylase activity
namespace: molecular_function
subset: gosubset_prok
xref: EC:4.1.1.-
xref: Reactome:24735 "gamma-glutamyl carboxylase activity"
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008489
name: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + glucosylceramide = lactosylceramide (galactosyl-beta-1,4-glucosylceramide) + UDP." [GOC:ai, PMID:9593693]
synonym: "LacCer synthase activity" EXACT []
synonym: "lactosylceramide synthase activity" EXACT []
synonym: "UDP-galactose glucosylceramide beta-1,4-galactosyltransferase activity" EXACT []
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0008490
name: arsenite secondary active transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0008491
def: "Catalysis of the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:jl]
subset: gosubset_prok
synonym: "arsenite porter activity" RELATED []
is_a: GO:0015105 ! arsenite transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0008492
name: cAMP generating peptide activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a gene product.
synonym: "cyclic AMP generating peptide activity" EXACT []
is_obsolete: true
consider: GO:0004016
consider: GO:0005179
consider: GO:0046058

[Term]
id: GO:0008493
name: tetracycline transporter activity
namespace: molecular_function
def: "Enables the directed movement of tetracycline into, out of, within or between cells. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "tetracyclin transporter activity" EXACT []
is_a: GO:0042895 ! antibiotic transporter activity

[Term]
id: GO:0008494
name: translation activator activity
namespace: molecular_function
def: "Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai]
is_a: GO:0090079 ! translation regulator activity, nucleic acid binding

[Term]
id: GO:0008495
name: protoheme IX farnesyltransferase activity
namespace: molecular_function
subset: gosubset_prok
synonym: "haem O synthase activity" EXACT []
synonym: "heme O synthase activity" EXACT []
synonym: "protohaem IX farnesyltransferase activity" EXACT []
xref: EC:2.5.1.-
is_a: GO:0004311 ! farnesyltranstransferase activity

[Term]
id: GO:0008496
name: mannan endo-1,6-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of 1,6-alpha-D-mannosidic linkages in unbranched 1,6-mannans." [EC:3.2.1.101]
synonym: "1,6-alpha-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.101]
synonym: "1,6-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.101]
synonym: "endo-1,6-beta-mannanase activity" EXACT [EC:3.2.1.101]
synonym: "endo-alpha-1->6-D-mannanase activity" EXACT [EC:3.2.1.101]
synonym: "endo-alpha-D-mannosidase activity" EXACT []
synonym: "exo-1,6-beta-mannanase activity" EXACT [EC:3.2.1.101]
synonym: "mannan endo-1,6-beta-mannosidase activity" EXACT [EC:3.2.1.101]
xref: EC:3.2.1.101
xref: MetaCyc:3.2.1.101-RXN
is_a: GO:0004559 ! alpha-mannosidase activity

[Term]
id: GO:0008498
name: phospholipid scrambling
namespace: molecular_function
def: "OBSOLETE. The trans-bilayer migration of phospholipids accelerated by a phospholipid scramblase upon binding calcium ions." [OMIM:604170]
comment: This term was made obsolete because it represents a biological process and not a molecular function.
is_obsolete: true
replaced_by: GO:0017121

[Term]
id: GO:0008499
name: UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP." [PMID:10212226]
synonym: "beta-1,3-GalTase activity" BROAD []
synonym: "beta3Gal-Ts activity" BROAD []
synonym: "UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase activity" EXACT []
synonym: "UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity" EXACT []
is_a: GO:0035250 ! UDP-galactosyltransferase activity
is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity

[Term]
id: GO:0008500
name: glycine-, glutamate-, thienylcyclohexylpiperidine binding
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it is a conglomeration of three terms.
is_obsolete: true
consider: GO:0016594
consider: GO:0016595
consider: GO:0016596

[Term]
id: GO:0008502
name: melatonin receptor activity
namespace: molecular_function
def: "Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0008503
name: benzodiazepine receptor activity
namespace: molecular_function
def: "Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity." [GOC:jl]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'chloride channel activity ; GO:0005254', 'GABA receptor activity ; GO:0016917' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'.
is_a: GO:0030594 ! neurotransmitter receptor activity

[Term]
id: GO:0008504
name: monoamine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015201
def: "Catalysis of the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of the membrane to the other." [ChEBI:25375, GOC:mah]
xref: Reactome:22834 "monoamine transmembrane transporter activity"
is_a: GO:0005275 ! amine transmembrane transporter activity

[Term]
id: GO:0008506
name: sucrose:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in)." [TC:2.A.1.5.3]
synonym: "hydrogen/sucrose transporter activity" BROAD []
synonym: "sucrose:proton symporter activity" EXACT []
is_a: GO:0005351 ! sugar:hydrogen symporter activity
is_a: GO:0008515 ! sucrose transmembrane transporter activity

[Term]
id: GO:0008507
name: sodium:iodide symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in)." [TC:2.A.21.5.1]
synonym: "sodium/iodide symporter activity" EXACT []
is_a: GO:0015373 ! monovalent anion:sodium symporter activity

[Term]
id: GO:0008508
name: bile acid:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in)." [TC:2.A.28.-.-]
synonym: "sodium/bile acid symporter activity" EXACT []
xref: Reactome:24856 "bile acid:sodium symporter activity"
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0015125 ! bile acid transmembrane transporter activity

[Term]
id: GO:0008509
name: anion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other." [GOC:def, GOC:df, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "anion transporter activity" EXACT []
xref: Reactome:3160 "anion transmembrane transporter activity"
is_a: GO:0015075 ! ion transmembrane transporter activity

[Term]
id: GO:0008510
name: sodium:bicarbonate symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in)." [TC:2.A.31.2.1]
synonym: "sodium/bicarbonate cotransporter activity" BROAD []
synonym: "sodium:bicarbonate cotransporter activity" BROAD []
is_a: GO:0015106 ! bicarbonate transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0008511
name: sodium:potassium:chloride symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)." [TC:2.A.30.1.1]
synonym: "sodium/potassium/chloride symporter activity" EXACT []
is_a: GO:0015377 ! cation:chloride symporter activity

[Term]
id: GO:0008512
name: sulfate:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in)." [TC:2.A.53.-.-]
synonym: "sulfate/hydrogen symporter activity" EXACT []
synonym: "sulfate:proton symporter activity" EXACT []
synonym: "sulphate:hydrogen symporter activity" EXACT []
is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015295 ! solute:hydrogen symporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0008513
name: secondary active organic cation transmembrane transporter activity
namespace: molecular_function
synonym: "organic cation porter activity" RELATED []
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0008514
name: organic anion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008509 ! anion transmembrane transporter activity

[Term]
id: GO:0008515
name: sucrose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0019188
def: "Catalysis of the transfer of sucrose from one side of the membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
synonym: "sucrose permease (PTS) activity" EXACT []
synonym: "sucrose permease activity" RELATED []
is_a: GO:0015154 ! disaccharide transmembrane transporter activity

[Term]
id: GO:0008516
name: hexose uniporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in)." [TC:2.A.1.1.5]
is_a: GO:0005351 ! sugar:hydrogen symporter activity
is_a: GO:0015149 ! hexose transmembrane transporter activity
is_a: GO:0015292 ! uniporter activity

[Term]
id: GO:0008517
name: folic acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of folic acid (pteroylglutamic acid) into, out of, within or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai]
synonym: "folate transporter activity" EXACT []
synonym: "vitamin B9 transporter activity" EXACT []
synonym: "vitamin M transporter activity" EXACT []
xref: Reactome:21930 "folic acid transporter activity"
is_a: GO:0051183 ! vitamin transporter activity
is_a: GO:0051184 ! cofactor transporter activity

[Term]
id: GO:0008518
name: reduced folate carrier activity
namespace: molecular_function
def: "Catalysis of the transfer of reduced folate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
synonym: "reduced folate transporter" BROAD []
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0008519
name: ammonium transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0022890 ! inorganic cation transmembrane transporter activity

[Term]
id: GO:0008520
name: L-ascorbate:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ascorbate(out) + Na+(out) = ascorbate(in) + Na+(in)." [TC:2.A.40.6.1]
synonym: "sodium-dependent L-ascorbic acid transporter" RELATED []
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0008521
name: acetyl-CoA transporter activity
namespace: molecular_function
def: "Enables the directed movement of acetyl-CoA into, out of, within or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai]
is_a: GO:0051185 ! coenzyme transporter activity

[Term]
id: GO:0008523
name: sodium-dependent multivitamin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate." [TC:2.A.21.5.2]
xref: Reactome:24902 "sodium-dependent multivitamin transmembrane transporter activity"
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0008524
name: glucose 6-phosphate:phosphate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + phosphate(in) = glucose 6-phosphate(in) + phosphate(out)." [TC:2.A.1.-.-]
is_a: GO:0015301 ! anion:anion antiporter activity
is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity
relationship: part_of GO:0005355 ! glucose transmembrane transporter activity

[Term]
id: GO:0008525
name: phosphatidylcholine transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of phosphatidylcholine into, out of, within or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0005548 ! phospholipid transporter activity

[Term]
id: GO:0008526
name: phosphatidylinositol transporter activity
namespace: molecular_function
def: "Enables the directed movement of phosphatidylinositol into, out of, within or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "phosphatidylinositol transfer" EXACT []
is_a: GO:0005548 ! phospholipid transporter activity

[Term]
id: GO:0008527
name: taste receptor activity
namespace: molecular_function
def: "Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph]
synonym: "gustatory receptor" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0008528
name: peptide receptor activity, G-protein coupled
namespace: molecular_function
def: "Combining with an extracellular or intracellular peptide to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state." [GOC:dph, GOC:tb]
synonym: "G protein coupled peptide receptor activity" EXACT []
synonym: "G-protein coupled peptide receptor activity" EXACT []
synonym: "G-protein-coupled peptide receptor activity" EXACT []
synonym: "peptide receptor activity, G protein coupled" EXACT []
is_a: GO:0001653 ! peptide receptor activity
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0008529
name: endogenous peptide receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with an intracellular peptide to initiate a change in cell activity." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
is_obsolete: true
consider: GO:0001653
consider: GO:0005622

[Term]
id: GO:0008530
name: exogenous peptide receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with an extracellular peptide to initiate a change in cell activity." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
is_obsolete: true
consider: GO:0001653
consider: GO:0005576

[Term]
id: GO:0008531
name: riboflavin kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + riboflavin = ADP + FMN." [EC:2.7.1.26]
subset: gosubset_prok
synonym: "ATP:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.26]
synonym: "FK" RELATED [EC:2.7.1.26]
synonym: "flavokinase activity" EXACT [EC:2.7.1.26]
synonym: "riboflavin kinase (phosphorylating)" EXACT [EC:2.7.1.26]
synonym: "riboflavine kinase activity" EXACT [EC:2.7.1.26]
xref: EC:2.7.1.26
xref: MetaCyc:RIBOFLAVINKIN-RXN
xref: Reactome:24927 "riboflavin kinase activity"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008532
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.149]
synonym: "galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149]
synonym: "GnTE activity" EXACT [EC:2.4.1.149]
synonym: "N-acetyllactosamine beta(1-3)N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149]
synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.149]
synonym: "UDP-GlcNAc:Galbeta1->4GlcNAcbeta-rbeta1->3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149]
synonym: "UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.149]
synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.149]
xref: EC:2.4.1.149
xref: MetaCyc:2.4.1.149-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0008533
name: astacin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'." [EC:3.4.24.21]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "Astacus proteinase activity" EXACT [EC:3.4.24.21]
synonym: "astacus proteinase activity" NARROW [EC:3.4.24.21]
synonym: "crayfish small-molecule proteinase activity" NARROW [EC:3.4.24.21]
xref: EC:3.4.24.21
xref: MetaCyc:3.4.24.21-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008534
name: oxidized purine base lesion DNA N-glycosylase activity
namespace: molecular_function
alt_id: GO:0003907
def: "Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296]
comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
subset: gosubset_prok
synonym: "2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23]
synonym: "2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23]
synonym: "8-oxoguanine DNA glycosylase activity" BROAD []
synonym: "bifunctional DNA glycosylase activity" BROAD []
synonym: "deoxyribonucleate glycosidase activity" EXACT [EC:3.2.2.23]
synonym: "DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]" RELATED [EC:3.2.2.23]
synonym: "DNA glycosylase/AP-lyase activity" BROAD []
synonym: "DNA glycosylase/beta-lyase activity" BROAD []
synonym: "DNA-formamidopyrimidine glycosylase activity" EXACT []
synonym: "fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23]
synonym: "Fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23]
synonym: "formamidopyrimidine-DNA glycosylase activity" EXACT []
synonym: "Fpg protein" RELATED [EC:3.2.2.23]
synonym: "purine-specific oxidized base lesion DNA N-glycosylase activity" RELATED []
xref: EC:3.2.2.23
xref: MetaCyc:3.2.2.23-RXN
xref: Reactome:24932 "oxidized purine base lesion DNA N-glycosylase activity"
is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity
is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity

[Term]
id: GO:0008535
name: respiratory chain complex IV assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm]
subset: gosubset_prok
synonym: "cytochrome c oxidase biogenesis" BROAD []
synonym: "cytochrome c oxidase complex assembly" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0008536
name: Ran GTPase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly." [GOC:rn, PMID:12787777, PMID:14726649]
synonym: "Ran protein binding" EXACT []
synonym: "Ran-binding protein" RELATED []
is_a: GO:0017016 ! Ras GTPase binding

[Term]
id: GO:0008537
name: proteasome activator complex
namespace: cellular_component
def: "A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex." [GOC:rb]
synonym: "PA28" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0022624 ! proteasome accessory complex

[Term]
id: GO:0008538
name: proteasome activator activity
namespace: molecular_function
def: "Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:rn, PMID:10428771]
synonym: "PA28" NARROW []
is_a: GO:0010860 ! proteasome regulator activity

[Term]
id: GO:0008539
name: proteasome inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:mah]
synonym: "PI-31" NARROW []
is_a: GO:0010860 ! proteasome regulator activity

[Term]
id: GO:0008540
name: proteasome regulatory particle, base subcomplex
namespace: cellular_component
def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:proteasome, GOC:rb]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0005838 ! proteasome regulatory particle

[Term]
id: GO:0008541
name: proteasome regulatory particle, lid subcomplex
namespace: cellular_component
def: "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0005838 ! proteasome regulatory particle

[Term]
id: GO:0008542
name: visual learning
namespace: biological_process
def: "Any process in an organism in which a change in behavior of an individual in response to repeated exposure to a visual cue." [GOC:jic, ISBN:0582227089]
synonym: "spatial learning" RELATED []
is_a: GO:0007612 ! learning
is_a: GO:0007632 ! visual behavior

[Term]
id: GO:0008543
name: fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb]
synonym: "FGF receptor signaling pathway" EXACT []
synonym: "FGF receptor signalling pathway" EXACT []
synonym: "FGFR signaling pathway" EXACT []
synonym: "fibroblast growth factor receptor signalling pathway" EXACT []
xref: Reactome:190236 "Signaling by FGFR"
xref: Reactome:190239 "FGFR3 ligand binding and activation"
xref: Reactome:190241 "FGFR2 ligand binding and activation"
xref: Reactome:190242 "FGFR1 ligand binding and activation"
xref: Reactome:190322 "FGFR4 ligand binding and activation"
xref: Reactome:190370 "FGFR1b ligand binding and activation"
xref: Reactome:190371 "FGFR3b ligand binding and activation"
xref: Reactome:190372 "FGFR3c ligand binding and activation"
xref: Reactome:190373 "FGFR1c ligand binding and activation"
xref: Reactome:190374 "FGFR1c and Klotho ligand binding and activation"
xref: Reactome:190375 "FGFR2c ligand binding and activation"
xref: Reactome:190376 "FGFR ligand binding and activation"
xref: Reactome:190377 "FGFR2b ligand binding and activation"
xref: Reactome:448876 "FGFR1b ligand binding and activation"
xref: Reactome:448877 "FGFR1 ligand binding and activation"
xref: Reactome:448878 "FGFR ligand binding and activation"
xref: Reactome:448879 "Signaling by FGFR"
xref: Reactome:448880 "FGFR1c ligand binding and activation"
xref: Reactome:448881 "FGFR2b ligand binding and activation"
xref: Reactome:448882 "FGFR2 ligand binding and activation"
xref: Reactome:448883 "FGFR2c ligand binding and activation"
xref: Reactome:448884 "FGFR3b ligand binding and activation"
xref: Reactome:448885 "FGFR3 ligand binding and activation"
xref: Reactome:448886 "FGFR3c ligand binding and activation"
xref: Reactome:448887 "FGFR4 ligand binding and activation"
xref: Reactome:448888 "FGFR1c and Klotho ligand binding and activation"
xref: Reactome:469993 "FGFR1b ligand binding and activation"
xref: Reactome:469994 "FGFR1 ligand binding and activation"
xref: Reactome:469995 "FGFR ligand binding and activation"
xref: Reactome:469996 "Signaling by FGFR"
xref: Reactome:469997 "FGFR1c ligand binding and activation"
xref: Reactome:469998 "FGFR2b ligand binding and activation"
xref: Reactome:469999 "FGFR2 ligand binding and activation"
xref: Reactome:470000 "FGFR2c ligand binding and activation"
xref: Reactome:470001 "FGFR3b ligand binding and activation"
xref: Reactome:470002 "FGFR3 ligand binding and activation"
xref: Reactome:470003 "FGFR3c ligand binding and activation"
xref: Reactome:470004 "FGFR4 ligand binding and activation"
xref: Reactome:470005 "FGFR1c and Klotho ligand binding and activation"
xref: Reactome:487698 "FGFR1b ligand binding and activation"
xref: Reactome:487699 "FGFR1 ligand binding and activation"
xref: Reactome:487700 "FGFR ligand binding and activation"
xref: Reactome:487701 "Signaling by FGFR"
xref: Reactome:487702 "FGFR1c ligand binding and activation"
xref: Reactome:487703 "FGFR2b ligand binding and activation"
xref: Reactome:487704 "FGFR2 ligand binding and activation"
xref: Reactome:487705 "FGFR2c ligand binding and activation"
xref: Reactome:487706 "FGFR3b ligand binding and activation"
xref: Reactome:487707 "FGFR3 ligand binding and activation"
xref: Reactome:487708 "FGFR3c ligand binding and activation"
xref: Reactome:487709 "FGFR4 ligand binding and activation"
xref: Reactome:487710 "FGFR1c and Klotho ligand binding and activation"
xref: Reactome:507650 "FGFR1b ligand binding and activation"
xref: Reactome:507651 "FGFR1 ligand binding and activation"
xref: Reactome:507652 "FGFR ligand binding and activation"
xref: Reactome:507653 "Signaling by FGFR"
xref: Reactome:507654 "FGFR1c ligand binding and activation"
xref: Reactome:507655 "FGFR2b ligand binding and activation"
xref: Reactome:507656 "FGFR2 ligand binding and activation"
xref: Reactome:507657 "FGFR2c ligand binding and activation"
xref: Reactome:507658 "FGFR3b ligand binding and activation"
xref: Reactome:507659 "FGFR3 ligand binding and activation"
xref: Reactome:507660 "FGFR3c ligand binding and activation"
xref: Reactome:507661 "FGFR4 ligand binding and activation"
xref: Reactome:507662 "FGFR1c and Klotho ligand binding and activation"
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0008544
name: epidermis development
namespace: biological_process
def: "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
synonym: "hypodermis development" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0007398 ! ectoderm development

[Term]
id: GO:0008545
name: JUN kinase kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase." [GOC:bf, PMID:11057897, PMID:11790549]
synonym: "JNKK" EXACT []
xref: EC:2.7.11.-
is_a: GO:0004708 ! MAP kinase kinase activity

[Term]
id: GO:0008546
name: microtubule/chromatin interaction
namespace: biological_process
def: "OBSOLETE. Physical interaction between microtubules and chromatin via DNA binding proteins." [PMID:10322137]
comment: This term was made obsolete because it represents a molecular function.
is_obsolete: true
consider: GO:0003677
consider: GO:0003682
consider: GO:0008017
consider: GO:0030674

[Term]
id: GO:0008547
name: protein-synthesizing GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. A GTPase involved in protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1a (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF1a catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs." [EC:3.6.5.3, MetaCyc:3.6.1.48-RXN]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0003924
replaced_by: GO:0006412
consider: GO:0008135

[Term]
id: GO:0008548
name: signal-recognition-particle GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Activity is associated with the signal-recognition particle, a protein and RNA-containing structure involved in endoplasmic reticulum-associated protein synthesis." [EC:3.6.5.4, MetaCyc:3.6.1.49-RXN]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0003924
replaced_by: GO:0005786

[Term]
id: GO:0008549
name: dynamin GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An enzyme that is involved in endocytosis and is instrumental in pinching off membrane vesicles." [EC:3.6.5.5, MetaCyc:3.6.1.50-RXN]
comment: This term was made obsolete because it represents a gene product.
synonym: "dynamine GTPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0006897

[Term]
id: GO:0008550
name: tubulin GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others." [EC:3.6.5.6, MetaCyc:3.6.1.51-RXN]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0003924
replaced_by: GO:0007021

[Term]
id: GO:0008551
name: cadmium-exporting ATPase activity
namespace: molecular_function
alt_id: GO:0008561
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) = ADP + phosphate + Cd2+(out)." [EC:3.6.3.3]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (Cd2+-exporting)" EXACT [EC:3.6.3.3]
synonym: "cadmium exporting ATPase activity" EXACT []
synonym: "cadmium-translocating P-type ATPase activity" RELATED [EC:3.6.3.3]
synonym: "Cd(2+)-exporting ATPase activity" EXACT [EC:3.6.3.3]
synonym: "Cd2+-exporting ATPase activity" EXACT [EC:3.6.3.3]
synonym: "cd2+-exporting ATPase activity" EXACT [EC:3.6.3.3]
xref: EC:3.6.3.3
xref: MetaCyc:3.6.3.3-RXN
is_a: GO:0015086 ! cadmium ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

[Term]
id: GO:0008552
name: zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: Me2+(in) + ATP = Me2+(out) + ADP + phosphate, where Me is Zn2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:3.A.3.6.2]
comment: This term was made obsolete because it represents more than one molecular function.
is_obsolete: true
consider: GO:0005385
consider: GO:0015086
consider: GO:0015087
consider: GO:0015094
consider: GO:0015099
consider: GO:0015662

[Term]
id: GO:0008553
name: hydrogen-exporting ATPase activity, phosphorylative mechanism
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism." [EC:3.6.3.6]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (H+-exporting)" EXACT [EC:3.6.3.6]
synonym: "H(+)-exporting ATPase activity" BROAD [EC:3.6.3.6]
synonym: "H(+)-transporting ATPase activity" BROAD [EC:3.6.3.6]
synonym: "H+-exporting ATPase activity" EXACT [EC:3.6.3.6]
synonym: "H+-transporting ATPase" BROAD [EC:3.6.3.6]
synonym: "hydrogen exporting ATPase activity, phosphorylative mechanism" EXACT []
synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED []
synonym: "proton transport ATPase activity" RELATED [EC:3.6.3.6]
synonym: "proton-exporting ATPase" RELATED [EC:3.6.3.6]
synonym: "proton-translocating ATPase activity" EXACT [EC:3.6.3.6]
synonym: "proton-translocating P-type ATPase activity" EXACT [EC:3.6.3.6]
synonym: "yeast plasma membrane ATPase" NARROW [EC:3.6.3.6]
synonym: "yeast plasma membrane H+-ATPase" NARROW [EC:3.6.3.6]
xref: EC:3.6.3.6
xref: MetaCyc:3.6.3.6-RXN
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

[Term]
id: GO:0008554
name: sodium-exporting ATPase activity, phosphorylative mechanism
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out); by a phosphorylative mechanism." [EC:3.6.3.7]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (Na+-exporting)" EXACT [EC:3.6.3.7]
synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED []
synonym: "Na(+)-exporting ATPase activity" EXACT [EC:3.6.3.7]
synonym: "Na(+)-transporting ATPase activity" BROAD [EC:3.6.3.7]
synonym: "Na+-exporting ATPase activity" EXACT [EC:3.6.3.7]
synonym: "Na+-transporting ATPase activity" EXACT [EC:3.6.3.7]
synonym: "sodium exporting ATPase activity, phosphorylative mechanism" EXACT []
synonym: "sodium transport ATPase activity" RELATED [EC:3.6.3.7]
synonym: "sodium-exporting ATPase activity" EXACT [EC:3.6.3.7]
synonym: "sodium-translocating P-type ATPase activity" RELATED [EC:3.6.3.7]
xref: EC:3.6.3.7
xref: MetaCyc:3.6.3.7-RXN
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

[Term]
id: GO:0008555
name: chloride-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cl-(out) = ADP + phosphate + Cl-(in)." [EC:3.6.3.11]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (Cl--importing)" EXACT [EC:3.6.3.11]
synonym: "chloride ABC transporter" NARROW []
synonym: "chloride transporting ATPase activity" EXACT []
synonym: "chloride-motive ATPase activity" EXACT [EC:3.6.3.11]
synonym: "chloride-translocating ATPase activity" EXACT [EC:3.6.3.11]
synonym: "Cl(-)-transporting ATPase activity" EXACT [EC:3.6.3.11]
synonym: "Cl--motive ATPase activity" EXACT [EC:3.6.3.11]
synonym: "Cl--translocating ATPase activity" EXACT [EC:3.6.3.11]
synonym: "Cl--transporting ATPase activity" EXACT [EC:3.6.3.11]
synonym: "cl--transporting ATPase activity" EXACT [EC:3.6.3.11]
xref: EC:3.6.3.11
xref: MetaCyc:3.6.3.11-RXN
is_a: GO:0015108 ! chloride transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

[Term]
id: GO:0008556
name: potassium-transporting ATPase activity
namespace: molecular_function
alt_id: GO:0015618
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in)." [EC:3.6.3.12]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (K+-importing)" EXACT [EC:3.6.3.12]
synonym: "K(+)-importing ATPase activity" NARROW [EC:3.6.3.12]
synonym: "K(+)-transporting ATPase activity" EXACT [EC:3.6.3.12]
synonym: "K+-importing ATPase activity" EXACT [EC:3.6.3.12]
synonym: "K+-translocating Kdp-ATPase activity" EXACT [EC:3.6.3.12]
synonym: "K+-transporting ATPase activity" EXACT []
synonym: "k+-transporting ATPase activity" EXACT [EC:3.6.3.12]
synonym: "multi-subunit K+-transport ATPase" NARROW [EC:3.6.3.12]
synonym: "potassium ABC transporter" NARROW []
synonym: "potassium transporting ATPase activity" EXACT []
synonym: "potassium-importing ATPase activity" NARROW [EC:3.6.3.12]
synonym: "potassium-uptake-ATPase activity" EXACT []
xref: EC:3.6.3.12
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

[Term]
id: GO:0008558
name: guanine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in)." [EC:3.6.3.37]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ATP phosphohydrolase (guanine-importing)" EXACT [EC:3.6.3.37]
synonym: "guanine ABC transporter" NARROW []
xref: EC:3.6.3.37
xref: MetaCyc:3.6.3.37-RXN
is_a: GO:0015208 ! guanine transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0008559
name: xenobiotic-transporting ATPase activity
namespace: molecular_function
alt_id: GO:0005226
alt_id: GO:0008560
def: "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (steroid-exporting)" EXACT [EC:3.6.3.44]
synonym: "ATP phosphohydrolase (xenobiotic-exporting)" EXACT [EC:3.6.3.44]
synonym: "MDR protein" RELATED [EC:3.6.3.44]
synonym: "multidrug resistance exporter" RELATED []
synonym: "multidrug-resistance protein" RELATED []
synonym: "P-glycoprotein" RELATED []
synonym: "PDR protein" RELATED [EC:3.6.3.44]
synonym: "pleiotropic-drug-resistance protein" RELATED [EC:3.6.3.44]
synonym: "steroid ABC transporter" NARROW []
synonym: "steroid-transporting ATPase activity" EXACT []
synonym: "xenobiotic ABC transporter" NARROW []
xref: EC:3.6.3.44
xref: MetaCyc:3.6.3.44-RXN
is_a: GO:0015239 ! multidrug transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances
is_a: GO:0042910 ! xenobiotic transporter activity

[Term]
id: GO:0008563
name: alpha-factor sex pheromone exporter
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + alpha-factor(in) = ADP + phosphate + alpha-factor(out). The export of the alpha-factor sex pheromone by an ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process." [EC:3.6.3.48]
comment: This term was made obsolete because this function does not exist; alpha-factor is secreted by the classical secretion pathway and not exported.
synonym: "alpha-factor-transporting ATPase" RELATED []
is_obsolete: true

[Term]
id: GO:0008564
name: protein-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the concomitant secretion of proteins." [EC:3.6.3.50]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ATP phosphohydrolase (protein-secreting)" EXACT [EC:3.6.3.50]
synonym: "protein-secreting ATPase activity" EXACT []
xref: EC:3.6.3.50
xref: MetaCyc:3.6.3.50-RXN
is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity

[Term]
id: GO:0008565
name: protein transporter activity
namespace: molecular_function
alt_id: GO:0015463
def: "Enables the directed movement of proteins into, out of, within or between cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_goa
subset: gosubset_prok
synonym: "enzyme transporter activity" NARROW []
synonym: "holin" RELATED []
synonym: "protein carrier activity" EXACT []
synonym: "protein transport chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb]
synonym: "secretin" RELATED []
is_a: GO:0022892 ! substrate-specific transporter activity

[Term]
id: GO:0008566
name: mitochondrial protein-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex." [EC:3.6.3.51]
comment: See also the cellular component term 'mitochondrial inner membrane presequence translocase complex ; GO:0005744'. Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ATP phosphohydrolase (mitochondrial protein-importing) activity" EXACT [EC:3.6.3.51]
xref: EC:3.6.3.51
xref: MetaCyc:3.6.3.51-RXN
is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity

[Term]
id: GO:0008567
name: dynein ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by dynein that provides the energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome." [EC:3.6.4.2]
comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information.
is_obsolete: true
consider: GO:0003777
consider: GO:0007018

[Term]
id: GO:0008568
name: microtubule-severing ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766]
comment: See also the cellular component term 'katanin complex ; GO:0008352'. Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ATP phosphohydrolase (tubulin-dimerizing)" EXACT [EC:3.6.4.3]
synonym: "katanin activity" NARROW [EC:3.6.4.3]
xref: EC:3.6.4.3
xref: MetaCyc:3.6.4.3-RXN
is_a: GO:0042623 ! ATPase activity, coupled

[Term]
id: GO:0008569
name: minus-end-directed microtubule motor activity
namespace: molecular_function
def: "Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP (or GTP)." [EC:3.6.4.5, GOC:mah]
synonym: "kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [EC:3.6.4.5]
synonym: "minus-end-directed kinesin ATPase activity" BROAD []
xref: EC:3.6.4.5
xref: MetaCyc:3.6.4.5-RXN
is_a: GO:0003777 ! microtubule motor activity

[Term]
id: GO:0008570
name: myosin ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by myosin that provides the energy for actomyosin contraction." [EC:3.6.4.1]
comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information.
is_obsolete: true
replaced_by: GO:0000146
consider: GO:0030048

[Term]
id: GO:0008571
name: non-chaperonin molecular chaperone ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin." [EC:3.6.4.10]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
replaced_by: GO:0042623
consider: GO:0006457

[Term]
id: GO:0008572
name: nucleoplasmin ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP required for the ATP-dependent assembly of nucleosome cores, in decondensation of sperm chromatin and in other histone-involving processes." [EC:3.6.4.11]
comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information.
is_obsolete: true
replaced_by: GO:0042623
consider: GO:0006333

[Term]
id: GO:0008573
name: peroxisome-assembly ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. ATP hydrolysis to import and assemble peroxisome components into the organelle." [EC:3.6.4.7]
comment: This term was made obsolete because it incorporates process information.
is_obsolete: true
replaced_by: GO:0042623
consider: GO:0007031

[Term]
id: GO:0008574
name: plus-end-directed microtubule motor activity
namespace: molecular_function
def: "Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP (or GTP)." [EC:3.6.4.4]
synonym: "kinesin activity" RELATED [EC:3.6.4.4]
synonym: "kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [EC:3.6.4.4]
synonym: "plus-end-directed kinesin ATPase activity" BROAD []
xref: EC:3.6.4.4
xref: MetaCyc:3.6.4.4-RXN
is_a: GO:0003777 ! microtubule motor activity

[Term]
id: GO:0008575
name: proteasome ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP for channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome." [EC:3.6.4.8]
comment: This term was made obsolete because it mentions a component term in the term text string.
is_obsolete: true
consider: GO:0016887

[Term]
id: GO:0008576
name: vesicle-fusing ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by an AAA-ATPase, involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments." [EC:3.6.4.6]
comment: This term was made obsolete because it incorporates process information.
is_obsolete: true
replaced_by: GO:0042623
consider: GO:0006944
consider: GO:0016192

[Term]
id: GO:0008579
name: JUN kinase phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate." [GOC:mah]
xref: EC:3.1.3.-
is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity

[Term]
id: GO:0008580
name: cytoskeletal regulator activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because 'cytoskeleton' is not an activity, and regulation of its distribution or modification belongs in the process ontology.
is_obsolete: true
consider: GO:0007010

[Term]
id: GO:0008581
name: ubiquitin-specific protease 5 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin." [ISBN:0120793709, MEROPS:c19p001]
comment: This term was made obsolete because it represents a gene product.
synonym: "ubiquitin isopeptidase T activity" EXACT []
is_obsolete: true
replaced_by: GO:0004221

[Term]
id: GO:0008582
name: regulation of synaptic growth at neuromuscular junction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0048742 ! regulation of skeletal muscle fiber development
is_a: GO:0051963 ! regulation of synaptogenesis
relationship: regulates GO:0051124 ! synaptic growth at neuromuscular junction

[Term]
id: GO:0008583
name: mystery cell fate differentiation
namespace: biological_process
def: "The process by which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster." [ISBN:0632030488, PMID:1295747]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0008584
name: male gonad development
namespace: biological_process
def: "The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure." [GOC:jic]
synonym: "testicular development" EXACT [GOC:sl]
synonym: "testis development" EXACT [GOC:sl]
is_a: GO:0008406 ! gonad development
relationship: part_of GO:0046546 ! development of primary male sexual characteristics

[Term]
id: GO:0008585
name: female gonad development
namespace: biological_process
def: "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:jic]
synonym: "ovarian development" EXACT [GOC:sl]
synonym: "ovary development" EXACT [GOC:sl]
is_a: GO:0008406 ! gonad development
relationship: part_of GO:0046545 ! development of primary female sexual characteristics

[Term]
id: GO:0008586
name: imaginal disc-derived wing vein morphogenesis
namespace: biological_process
def: "The process by which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_sensu]
synonym: "wing vein morphogenesis" EXACT []
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0008587
name: imaginal disc-derived wing margin morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. Morphogenesis pertains to the creation of form. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238]
comment: See also the fly_anatomy.ontology term 'wing margin ; FBbt:00005378'.
synonym: "wing margin morphogenesis" EXACT []
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0008588
name: release of cytoplasmic sequestered NF-kappaB
namespace: biological_process
def: "The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus." [GOC:jl]
synonym: "activation of NF-kappa B" RELATED []
synonym: "negative regulation of cytoplasmic NF-kappaB retention" RELATED []
synonym: "negative regulation of cytoplasmic NF-kappaB sequestering" RELATED []
synonym: "negative regulation of cytoplasmic NF-kappaB sequestration" RELATED []
synonym: "negative regulation of cytoplasmic NF-kappaB storage" RELATED []
synonym: "release of NF-kappaB sequestered in cytoplasm" EXACT []
synonym: "release of NF-kappaB stored in cytoplasm" EXACT []
is_a: GO:0042346 ! positive regulation of NF-kappaB import into nucleus
relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB cascade

[Term]
id: GO:0008589
name: regulation of smoothened signaling pathway
namespace: biological_process
alt_id: GO:0007226
alt_id: GO:0043109
def: "Any process that modulates the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
synonym: "regulation of smoothened activity" RELATED []
synonym: "regulation of smoothened by patched" RELATED []
synonym: "regulation of smoothened receptor activity by patched" RELATED []
synonym: "regulation of smoothened signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0007224 ! smoothened signaling pathway

[Term]
id: GO:0008591
name: regulation of Wnt receptor signaling pathway, calcium modulating pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "regulation of frizzled-2 signaling pathway" EXACT []
synonym: "regulation of frizzled-2 signalling pathway" EXACT []
is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway
relationship: regulates GO:0007223 ! Wnt receptor signaling pathway, calcium modulating pathway

[Term]
id: GO:0008592
name: regulation of Toll signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
synonym: "regulation of Tl signaling pathway" EXACT []
synonym: "regulation of Tl signalling pathway" EXACT []
synonym: "regulation of Toll signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0008063 ! Toll signaling pathway

[Term]
id: GO:0008593
name: regulation of Notch signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
synonym: "regulation of N signaling pathway" EXACT []
synonym: "regulation of N signalling pathway" EXACT []
synonym: "regulation of Notch signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0007219 ! Notch signaling pathway

[Term]
id: GO:0008594
name: photoreceptor cell morphogenesis
namespace: biological_process
def: "The process by which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jic, GOC:mah]
synonym: "photoreceptor development" RELATED []
is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation
relationship: part_of GO:0042461 ! photoreceptor cell development

[Term]
id: GO:0008595
name: anterior/posterior axis specification, embryo
namespace: biological_process
def: "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
synonym: "anterior/posterior axis determination, embryo" RELATED [GOC:dph]
is_a: GO:0000578 ! embryonic axis specification
is_a: GO:0009948 ! anterior/posterior axis specification
relationship: part_of GO:0007351 ! tripartite regional subdivision

[Term]
id: GO:0008597
name: calcium-dependent protein serine/threonine phosphatase regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase." [EC:3.1.3.16, GOC:ai]
synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic regulator activity" NARROW []
xref: Reactome:25079 "calcium-dependent protein serine/threonine phosphatase regulator activity"
is_a: GO:0019888 ! protein phosphatase regulator activity

[Term]
id: GO:0008599
name: protein phosphatase type 1 regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme protein phosphatase type 1." [GOC:ai]
synonym: "protein phosphatase type 1, intrinsic regulator activity" NARROW []
xref: Reactome:25081 "protein phosphatase type 1 regulator activity"
is_a: GO:0019888 ! protein phosphatase regulator activity

[Term]
id: GO:0008601
name: protein phosphatase type 2A regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme protein phosphatase type 2A." [GOC:ai]
synonym: "protein phosphatase type 2A, intrinsic regulator activity" NARROW []
is_a: GO:0019888 ! protein phosphatase regulator activity

[Term]
id: GO:0008603
name: cAMP-dependent protein kinase regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai]
subset: gosubset_prok
synonym: "3',5' cAMP-dependent protein kinase regulator activity" EXACT []
synonym: "3',5'-cAMP-dependent protein kinase regulator activity" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase regulator activity" EXACT []
synonym: "cAMP-dependent protein kinase, intrinsic regulator activity" NARROW []
synonym: "cyclic AMP-dependent protein kinase regulator activity" EXACT []
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0008605
name: protein kinase CK2 regulator activity
namespace: molecular_function
def: "OBSOLETE. Modulation of the activity of the enzyme protein kinase CK2." [GOC:ai]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
synonym: "casein kinase II, regulator" EXACT []
synonym: "protein kinase CK2, intrinsic regulator activity" NARROW []
is_obsolete: true
replaced_by: GO:0019887

[Term]
id: GO:0008607
name: phosphorylase kinase regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme phosphorylase kinase." [EC:2.7.11.19]
synonym: "phosphorylase kinase, intrinsic regulator activity" NARROW []
xref: EC:2.7.1.-
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0008608
name: attachment of spindle microtubules to kinetochore
namespace: biological_process
def: "The process by which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137]
synonym: "amphotelic attachment" RELATED []
synonym: "bipolar attachment" RELATED []
synonym: "correction of merotelic attachment" NARROW []
synonym: "kinetochore microtubule interaction" BROAD []
synonym: "kinetochore-microtubule attachment" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "kinetochore-microtubule interaction" BROAD []
synonym: "microtubule anchoring at kinetochore" EXACT []
synonym: "microtubule and kinetochore interaction" RELATED []
synonym: "microtubule capture" NARROW []
synonym: "prevention of merotelic attachment" NARROW []
synonym: "spindle kinetochore attachment" EXACT []
is_a: GO:0051313 ! attachment of spindle microtubules to chromosome

[Term]
id: GO:0008609
name: alkylglycerone-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion." [EC:2.5.1.26]
subset: gosubset_prok
synonym: "1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase activity" EXACT [EC:2.5.1.26]
synonym: "alkyl DHAP synthetase activity" EXACT [EC:2.5.1.26]
synonym: "alkyl-DHAP" RELATED [EC:2.5.1.26]
synonym: "alkyl-DHAP synthase activity" EXACT [EC:2.5.1.26]
synonym: "alkyldihydroxyacetone phosphate synthetase activity" EXACT [EC:2.5.1.26]
synonym: "alkyldihydroxyacetonephosphate synthase activity" EXACT [EC:2.5.1.26]
synonym: "DHAP-AT" RELATED [EC:2.5.1.26]
synonym: "dihydroxyacetone-phosphate acyltransferase activity" EXACT [EC:2.5.1.26]
xref: EC:2.5.1.26
xref: MetaCyc:ALKYLGLYCERONE-PHOSPHATE-SYNTHASE-RXN
xref: Reactome:25371 "alkylglycerone-phosphate synthase activity"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0008610
name: lipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
subset: gosubset_prok
synonym: "lipid anabolism" EXACT []
synonym: "lipid biosynthesis" EXACT []
synonym: "lipid formation" EXACT []
synonym: "lipid synthesis" EXACT []
synonym: "lipogenesis" EXACT [GOC:sl]
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0008611
name: ether lipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [GOC:ma, ISBN:0198547684, PMID:15337120]
subset: gosubset_prok
synonym: "ether lipid anabolism" EXACT []
synonym: "ether lipid biosynthesis" EXACT []
synonym: "ether lipid formation" EXACT []
synonym: "ether lipid synthesis" EXACT []
synonym: "plasmalogen biosynthetic process" NARROW []
xref: Reactome:448498 "Plasmalogen biosynthesis"
xref: Reactome:469628 "Plasmalogen biosynthesis"
xref: Reactome:487347 "Plasmalogen biosynthesis"
xref: Reactome:507298 "Plasmalogen biosynthesis"
xref: Reactome:517312 "Plasmalogen biosynthesis"
xref: Reactome:526197 "Plasmalogen biosynthesis"
xref: Reactome:557703 "Plasmalogen biosynthesis"
xref: Reactome:568748 "Plasmalogen biosynthesis"
xref: Reactome:581952 "Plasmalogen biosynthesis"
xref: Reactome:592859 "Plasmalogen biosynthesis"
xref: Reactome:599605 "Plasmalogen biosynthesis"
xref: Reactome:602410 "Plasmalogen biosynthesis"
xref: Reactome:75896 "Plasmalogen biosynthesis"
is_a: GO:0045017 ! glycerolipid biosynthetic process
is_a: GO:0046485 ! ether lipid metabolic process
is_a: GO:0046504 ! glycerol ether biosynthetic process

[Term]
id: GO:0008612
name: peptidyl-lysine modification to hypusine
namespace: biological_process
alt_id: GO:0046515
def: "The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116]
subset: gosubset_prok
synonym: "hypusine anabolism" EXACT []
synonym: "hypusine anabolism from peptidyl-lysine" EXACT []
synonym: "hypusine biosynthesis" EXACT []
synonym: "hypusine biosynthetic process" EXACT []
synonym: "hypusine biosynthetic process from peptidyl-lysine" EXACT []
synonym: "hypusine formation" EXACT []
synonym: "hypusine formation from peptidyl-lysine" EXACT []
synonym: "hypusine synthesis" EXACT []
synonym: "hypusine synthesis from peptidyl-lysine" EXACT []
xref: Reactome:204626 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:449069 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:470182 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:487866 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:507839 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:517745 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:526582 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:531382 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:536754 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:542509 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:547832 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:552403 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:558013 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:568663 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:581866 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:585926 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:592770 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:595501 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:597400 "Hypusine synthesis from eIF5A-lysine"
xref: Reactome:598180 "Hypusine synthesis from eIF5A-lysine"
xref: RESID:AA0116
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0046516 ! hypusine metabolic process

[Term]
id: GO:0008613
name: diuretic hormone activity
namespace: molecular_function
def: "The action characteristic of a diuretic hormone, any peptide hormone that, upon receptor binding, regulates water balance and fluid secretion." [GOC:mah, InterPro:IPR003621, PMID:8618894]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0008614
name: pyridoxine metabolic process
namespace: biological_process
alt_id: GO:0006773
def: "The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "pyridoxine metabolism" EXACT []
is_a: GO:0042816 ! vitamin B6 metabolic process

[Term]
id: GO:0008615
name: pyridoxine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds." [GOC:ai]
subset: gosubset_prok
synonym: "pyridoxine anabolism" EXACT []
synonym: "pyridoxine biosynthesis" EXACT []
synonym: "pyridoxine formation" EXACT []
synonym: "pyridoxine synthesis" EXACT []
xref: MetaCyc:PYRIDOXSYN-PWY
is_a: GO:0008614 ! pyridoxine metabolic process
is_a: GO:0042819 ! vitamin B6 biosynthetic process

[Term]
id: GO:0008616
name: queuosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "queuosine anabolism" EXACT []
synonym: "queuosine biosynthesis" EXACT []
synonym: "queuosine formation" EXACT []
synonym: "queuosine synthesis" EXACT []
is_a: GO:0006400 ! tRNA modification
is_a: GO:0046116 ! queuosine metabolic process
is_a: GO:0046118 ! 7-methylguanosine biosynthetic process

[Term]
id: GO:0008617
name: guanosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "guanosine metabolism" EXACT []
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0008618
name: 7-methylguanosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "7-methylguanosine metabolism" EXACT []
is_a: GO:0008617 ! guanosine metabolic process

[Term]
id: GO:0008619
name: RHEB small monomeric GTPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47, PMID:12893813]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0003924
consider: GO:0001558
consider: GO:0051726

[Term]
id: GO:0008622
name: epsilon DNA polymerase complex
namespace: cellular_component
def: "A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." [PMID:15814431, PMID:9745046]
synonym: "DNA polymerase epsilon complex" EXACT [CORUM:420]
is_a: GO:0042575 ! DNA polymerase complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000109 ! nucleotide-excision repair complex
relationship: part_of GO:0043601 ! nuclear replisome

[Term]
id: GO:0008623
name: chromatin accessibility complex
namespace: cellular_component
alt_id: GO:0016588
def: "A multisubunit complex that uses ATP to increase the general accessibility of DNA in chromatin. Unlike other known chromatin remodeling complexes, CHRAC can also function during chromatin assembly; it uses ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing." [GOC:bf, PMID:9252192]
synonym: "CHRAC" EXACT []
synonym: "ISW2 complex" NARROW []
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0008624
name: induction of apoptosis by extracellular signals
namespace: biological_process
def: "Any process induced by extracellular signals that directly activates any of the steps required for cell death by apoptosis." [GOC:ai]
xref: Reactome:109607 "Extrinsic Pathway for Apoptosis"
xref: Reactome:193681 "Ceramide signalling"
xref: Reactome:204998 "Cell death signalling via NRAGE, NRIF and NADE"
xref: Reactome:438538 "FASL binds FAS Receptor"
xref: Reactome:448509 "Cell death signalling via NRAGE, NRIF and NADE"
xref: Reactome:449095 "Extrinsic Pathway for Apoptosis"
xref: Reactome:449096 "FasL/ CD95L signaling"
xref: Reactome:449097 "Death Receptor Signalling"
xref: Reactome:449263 "Ceramide signalling"
xref: Reactome:460575 "FASL binds FAS Receptor"
xref: Reactome:469639 "Cell death signalling via NRAGE, NRIF and NADE"
xref: Reactome:470207 "Extrinsic Pathway for Apoptosis"
xref: Reactome:470208 "FasL/ CD95L signaling"
xref: Reactome:470209 "Death Receptor Signalling"
xref: Reactome:470382 "Ceramide signalling"
xref: Reactome:479526 "FASL binds FAS Receptor"
xref: Reactome:487551 "Cell death signalling via NRAGE, NRIF and NADE"
xref: Reactome:487894 "Extrinsic Pathway for Apoptosis"
xref: Reactome:487895 "FasL/ CD95L signaling"
xref: Reactome:487896 "Death Receptor Signalling"
xref: Reactome:488063 "Ceramide signalling"
xref: Reactome:507507 "Cell death signalling via NRAGE, NRIF and NADE"
xref: Reactome:507869 "Extrinsic Pathway for Apoptosis"
xref: Reactome:508021 "Ceramide signalling"
xref: Reactome:508062 "Death Receptor Signalling"
xref: Reactome:517492 "Cell death signalling via NRAGE, NRIF and NADE"
xref: Reactome:517882 "Ceramide signalling"
xref: Reactome:526361 "Cell death signalling via NRAGE, NRIF and NADE"
xref: Reactome:526705 "Ceramide signalling"
xref: Reactome:531479 "Ceramide signalling"
xref: Reactome:536864 "Ceramide signalling"
xref: Reactome:542618 "Ceramide signalling"
xref: Reactome:547934 "Ceramide signalling"
xref: Reactome:73887 "Death Receptor Signalling"
xref: Reactome:75157 "FasL/ CD95L signaling"
xref: Reactome:75244 "FASL binds FAS Receptor"
is_a: GO:0006917 ! induction of apoptosis

[Term]
id: GO:0008625
name: induction of apoptosis via death domain receptors
namespace: biological_process
is_a: GO:0008624 ! induction of apoptosis by extracellular signals

[Term]
id: GO:0008626
name: induction of apoptosis by granzyme
namespace: biological_process
is_a: GO:0008624 ! induction of apoptosis by extracellular signals

[Term]
id: GO:0008627
name: induction of apoptosis by ionic changes
namespace: biological_process
is_a: GO:0008624 ! induction of apoptosis by extracellular signals

[Term]
id: GO:0008628
name: induction of apoptosis by hormones
namespace: biological_process
def: "Any process induced by hormones that directly activates any of the steps required for cell death by apoptosis." [GOC:bf]
is_a: GO:0008624 ! induction of apoptosis by extracellular signals
is_a: GO:0035081 ! induction of programmed cell death by hormones

[Term]
id: GO:0008629
name: induction of apoptosis by intracellular signals
namespace: biological_process
def: "Any process induced by intracellular signals that directly activates any of the steps required for cell death by apoptosis." [GOC:ai]
xref: Reactome:109606 "Intrinsic Pathway for Apoptosis"
xref: Reactome:448684 "Intrinsic Pathway for Apoptosis"
xref: Reactome:469807 "Intrinsic Pathway for Apoptosis"
xref: Reactome:487767 "Intrinsic Pathway for Apoptosis"
xref: Reactome:507461 "Intrinsic Pathway for Apoptosis"
xref: Reactome:517893 "Intrinsic Pathway for Apoptosis"
xref: Reactome:526718 "Intrinsic Pathway for Apoptosis"
xref: Reactome:531493 "Intrinsic Pathway for Apoptosis"
xref: Reactome:536879 "Intrinsic Pathway for Apoptosis"
xref: Reactome:542633 "Intrinsic Pathway for Apoptosis"
xref: Reactome:547948 "Intrinsic Pathway for Apoptosis"
xref: Reactome:552523 "Intrinsic Pathway for Apoptosis"
xref: Reactome:558145 "Intrinsic Pathway for Apoptosis"
xref: Reactome:568770 "Intrinsic Pathway for Apoptosis"
xref: Reactome:581973 "Intrinsic Pathway for Apoptosis"
xref: Reactome:592882 "Intrinsic Pathway for Apoptosis"
xref: Reactome:595584 "Intrinsic Pathway for Apoptosis"
is_a: GO:0006917 ! induction of apoptosis

[Term]
id: GO:0008630
name: DNA damage response, signal transduction resulting in induction of apoptosis
namespace: biological_process
def: "A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death)." [GOC:go_curators]
is_a: GO:0008629 ! induction of apoptosis by intracellular signals
is_a: GO:0042770 ! DNA damage response, signal transduction

[Term]
id: GO:0008631
name: induction of apoptosis by oxidative stress
namespace: biological_process
def: "The activation, by oxidative stress, of any of the steps required for cell death by apoptosis." [GOC:ai]
is_a: GO:0008629 ! induction of apoptosis by intracellular signals

[Term]
id: GO:0008633
name: activation of pro-apoptotic gene products
namespace: biological_process
def: "The conversion of proteins that induce or sustain apoptosis to an active form." [GOC:mah]
synonym: "induction of pro-apoptotic gene products" RELATED []
xref: Reactome:111446 "Activation of BIM and translocation to mitochondria"
xref: Reactome:111447 "Activation of BAD and translocation to mitochondria"
xref: Reactome:111448 "Activation of NOXA and translocation to mitochondria"
xref: Reactome:111452 "Activation and oligomerization of BAK protein"
xref: Reactome:114294 "Activation, translocation and oligomerization of BAX"
xref: Reactome:114452 "Activation of BH3-only proteins"
xref: Reactome:139893 "Granzyme-B activates BID by cleavage"
xref: Reactome:139895 "tBID activates BAK protein"
xref: Reactome:139898 "Caspase-8 activates BID by cleavage"
xref: Reactome:139910 "Activation of BMF and translocation to mitochondria"
xref: Reactome:139915 "Activation of PUMA and translocation to mitochondria"
xref: Reactome:140534 "Caspase-8 is formed from procaspase-8"
xref: Reactome:433897 "Caspase-8 activates BID by cleavage"
xref: Reactome:440238 "Granzyme-B activates BID by cleavage"
xref: Reactome:447225 "tBID activates BAK protein"
xref: Reactome:448682 "Activation of BAD and translocation to mitochondria"
xref: Reactome:448683 "Activation of BH3-only proteins"
xref: Reactome:448954 "Activation, myristolyation of BID and translocation to mitochondria"
xref: Reactome:449094 "Caspase-8 is formed from procaspase-8"
xref: Reactome:449218 "Activation and oligomerization of BAK protein"
xref: Reactome:449219 "Activation, translocation and oligomerization of BAX"
xref: Reactome:449246 "Activation of BIM and translocation to mitochondria"
xref: Reactome:449247 "Activation of BMF and translocation to mitochondria"
xref: Reactome:449300 "Activation of PUMA and translocation to mitochondria"
xref: Reactome:456444 "Caspase-8 activates BID by cleavage"
xref: Reactome:461989 "Granzyme-B activates BID by cleavage"
xref: Reactome:468485 "tBID activates BAK protein"
xref: Reactome:469805 "Activation of BAD and translocation to mitochondria"
xref: Reactome:469806 "Activation of BH3-only proteins"
xref: Reactome:470073 "Activation, myristolyation of BID and translocation to mitochondria"
xref: Reactome:470206 "Caspase-8 is formed from procaspase-8"
xref: Reactome:470337 "Activation and oligomerization of BAK protein"
xref: Reactome:470338 "Activation, translocation and oligomerization of BAX"
xref: Reactome:470365 "Activation of BIM and translocation to mitochondria"
xref: Reactome:470366 "Activation of BMF and translocation to mitochondria"
xref: Reactome:476298 "Caspase-8 activates BID by cleavage"
xref: Reactome:480763 "Granzyme-B activates BID by cleavage"
xref: Reactome:486285 "tBID activates BAK protein"
xref: Reactome:487766 "Activation, myristolyation of BID and translocation to mitochondria"
xref: Reactome:487893 "Caspase-8 is formed from procaspase-8"
xref: Reactome:488016 "Activation and oligomerization of BAK protein"
xref: Reactome:488044 "Activation of BMF and translocation to mitochondria"
xref: Reactome:488045 "Activation of BH3-only proteins"
xref: Reactome:507459 "Activation of BAD and translocation to mitochondria"
xref: Reactome:507460 "Activation of BH3-only proteins"
xref: Reactome:507868 "Caspase-8 is formed from procaspase-8"
xref: Reactome:507979 "Activation, translocation and oligomerization of BAX"
xref: Reactome:75108 "Activation, myristolyation of BID and translocation to mitochondria"
is_a: GO:0043065 ! positive regulation of apoptosis
relationship: part_of GO:0006915 ! apoptosis

[Term]
id: GO:0008634
name: negative regulation of survival gene product expression
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of survival gene product activity" BROAD []
synonym: "down-regulation of survival gene product activity" BROAD []
synonym: "downregulation of survival gene product activity" BROAD []
synonym: "inhibition of survival gene product activity" NARROW []
synonym: "negative regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb]
synonym: "negative regulation of survival gene products" BROAD []
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0043065 ! positive regulation of apoptosis
is_a: GO:0045884 ! regulation of survival gene product expression

[Term]
id: GO:0008635
name: activation of caspase activity by cytochrome c
namespace: biological_process
def: "Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, mediated by cytochrome c." [GOC:dph, GOC:jl, GOC:tb, Wikipedia:Caspase]
synonym: "caspase activation via cytochrome c" EXACT [GOC:dph, GOC:tb]
xref: Reactome:111459 "Activation of caspases through apoptosome-mediated cleavage"
xref: Reactome:448977 "Activation of caspases through apoptosome-mediated cleavage"
xref: Reactome:470092 "Activation of caspases through apoptosome-mediated cleavage"
xref: Reactome:487787 "Activation of caspases through apoptosome-mediated cleavage"
xref: Reactome:507751 "Activation of caspases through apoptosome-mediated cleavage"
is_a: GO:0006919 ! activation of caspase activity

[Term]
id: GO:0008636
name: activation of caspase activity by protein amino acid phosphorylation
namespace: biological_process
def: "Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, by the addition of a phosphate group." [GOC:dph, GOC:jl, GOC:tb, Wikipedia:Caspase]
synonym: "caspase activation via phosphorylation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006468 ! protein amino acid phosphorylation
is_a: GO:0006919 ! activation of caspase activity

[Term]
id: GO:0008637
name: apoptotic mitochondrial changes
namespace: biological_process
def: "The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah]
is_a: GO:0007005 ! mitochondrion organization
relationship: part_of GO:0006915 ! apoptosis

[Term]
id: GO:0008638
name: protein tagging activity
namespace: molecular_function
def: "OBSOLETE. Covalent addition of a specific tagging molecule to a protein, targeting the tagged protein for some fate e.g. degradation." [GOC:jl]
comment: This term was made obsolete because it represents a biological process and a molecular function.
is_obsolete: true
consider: GO:0005515
consider: GO:0006464
consider: GO:0031386

[Term]
id: GO:0008641
name: small protein activating enzyme activity
namespace: molecular_function
alt_id: GO:0008642
def: "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "ubiquitin-like activating enzyme activity" NARROW []
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0008643
name: carbohydrate transport
namespace: biological_process
alt_id: GO:0006861
alt_id: GO:0008644
def: "The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "sugar transport" NARROW []
is_a: GO:0006810 ! transport

[Term]
id: GO:0008645
name: hexose transport
namespace: biological_process
def: "The directed movement of hexose into, out of, within or between cells by means of some external agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule." [GOC:ai]
subset: gosubset_prok
xref: Reactome:189200 "Hexose uptake"
xref: Reactome:449305 "Hexose uptake"
xref: Reactome:470424 "Hexose uptake"
xref: Reactome:488102 "Hexose uptake"
xref: Reactome:508071 "Hexose uptake"
is_a: GO:0015749 ! monosaccharide transport

[Term]
id: GO:0008646
name: high-affinity hexose transport
namespace: biological_process
def: "The directed, high-affinity movement of a hexose into, out of, within or between cells by means of some external agent such as a transporter or pore. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah]
is_a: GO:0008645 ! hexose transport
is_a: GO:0034219 ! carbohydrate transmembrane transport

[Term]
id: GO:0008647
name: low-affinity hexose transport
namespace: biological_process
def: "The directed, low-affinity movement of a hexose into, out of, within or between cells by means of some external agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah]
is_a: GO:0008645 ! hexose transport
is_a: GO:0034219 ! carbohydrate transmembrane transport

[Term]
id: GO:0008648
name: tachykinin
namespace: molecular_function
def: "OBSOLETE. A family of hormones that stimulate secretion of saliva and cause smooth muscle contraction and vasodilation." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0005102
consider: GO:0045909
consider: GO:0045987
consider: GO:0046878

[Term]
id: GO:0008649
name: rRNA methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008173 ! RNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008650
name: rRNA (uridine-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine." [GOC:mah]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity

[Term]
id: GO:0008651
name: actin polymerizing activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
is_obsolete: true
replaced_by: GO:0030041
replaced_by: GO:0042802

[Term]
id: GO:0008652
name: cellular amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cellular amino acid anabolism" EXACT []
synonym: "cellular amino acid biosynthesis" EXACT []
synonym: "cellular amino acid formation" EXACT []
synonym: "cellular amino acid synthesis" EXACT []
xref: Wikipedia:Amino_acid_synthesis
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0009309 ! amine biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0008653
name: lipopolysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "lipopolysaccharide metabolism" EXACT []
synonym: "LPS metabolic process" EXACT []
is_a: GO:0044255 ! cellular lipid metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0008654
name: phospholipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phospholipid anabolism" EXACT []
synonym: "phospholipid biosynthesis" EXACT []
synonym: "phospholipid formation" EXACT []
synonym: "phospholipid synthesis" EXACT []
xref: MetaCyc:LIPASYN-PWY
xref: MetaCyc:PHOSLIPSYN-PWY
xref: MetaCyc:PHOSLIPSYN2-PWY
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0008655
name: pyrimidine salvage
namespace: biological_process
def: "Any process that generates a pyrimidine, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0034404 ! nucleobase, nucleoside and nucleotide biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0008656
name: caspase activator activity
namespace: molecular_function
def: "Increases the rate of proteolysis catalyzed by a caspase." [GOC:mah]
is_a: GO:0016505 ! apoptotic protease activator activity
is_a: GO:0043028 ! caspase regulator activity

[Term]
id: GO:0008657
name: DNA topoisomerase (ATP-hydrolyzing) inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah]
synonym: "DNA gyrase inhibitor activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0008658
name: penicillin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008144 ! drug binding
is_a: GO:0031406 ! carboxylic acid binding

[Term]
id: GO:0008659
name: (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.-, GOC:ai]
synonym: "(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity" EXACT []
synonym: "(3R)-hydroxymyristoyl-ACP dehydratase activity" EXACT []
xref: EC:4.2.1.-
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008660
name: 1-aminocyclopropane-1-carboxylate deaminase activity
namespace: molecular_function
alt_id: GO:0018806
def: "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH3." [EC:3.5.99.7]
comment: Note that this function was formerly EC:4.1.99.4.
subset: gosubset_prok
synonym: "1-aminocyclopropane carboxylic acid deaminase activity" EXACT [EC:3.5.99.7]
synonym: "1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)" EXACT [EC:3.5.99.7]
synonym: "1-aminocyclopropane-1-carboxylate endolyase (deaminating) activity" EXACT [EC:3.5.99.7]
synonym: "ACC deaminase activity" EXACT [EC:3.5.99.7]
xref: EC:3.5.99.7
xref: MetaCyc:4.1.99.4-RXN
xref: UM-BBD_enzymeID:e0274
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0008661
name: 1-deoxy-D-xylulose-5-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2." [EC:2.2.1.7]
subset: gosubset_prok
synonym: "1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity" EXACT []
synonym: "1-deoxyxylulose-5-phosphate synthase activity" EXACT []
synonym: "DOXP synthase activity" EXACT []
synonym: "DXP-synthase activity" EXACT []
synonym: "pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.7]
xref: EC:2.2.1.7
xref: MetaCyc:DXS-RXN
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0008662
name: 1-phosphofructokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.56]
subset: gosubset_prok
synonym: "1-phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.56]
synonym: "ATP:D-fructose-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.56]
synonym: "D-fructose-1-phosphate kinase activity" EXACT [EC:2.7.1.56]
synonym: "fructose 1-phosphate kinase activity" EXACT [EC:2.7.1.56]
synonym: "fructose-1-phosphate kinase activity" EXACT [EC:2.7.1.56]
synonym: "phosphofructokinase 1" RELATED [EC:2.7.1.56]
xref: EC:2.7.1.56
xref: MetaCyc:1PFRUCTPHOSN-RXN
is_a: GO:0008443 ! phosphofructokinase activity

[Term]
id: GO:0008663
name: 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate." [EC:3.1.4.16]
subset: gosubset_prok
synonym: "2',3 '-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.16]
synonym: "2',3'-cyclic AMP 2'-phosphohydrolase activity" EXACT [EC:3.1.4.16]
synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.16]
synonym: "2',3'-cyclic nucleotidase activity" EXACT [EC:3.1.4.16]
synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.16]
synonym: "2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity" EXACT [EC:3.1.4.16]
synonym: "2':3'-cyclic phosphodiesterase activity" EXACT [EC:3.1.4.16]
synonym: "cyclic 2',3'-nucleotide 2'-phosphodiesterase activity" EXACT [EC:3.1.4.16]
synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.16]
synonym: "cyclic phosphodiesterase:3'-nucleotidase activity" EXACT [EC:3.1.4.16]
synonym: "nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity" EXACT [EC:3.1.4.16]
synonym: "ribonucleoside 2',3'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.16]
xref: EC:3.1.4.16
xref: MetaCyc:CYCPHOSDIESTER-RXN
is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0008664
name: 2'-5'-RNA ligase activity
namespace: molecular_function
def: "Catalysis of the formation of a phosphodiester bond between the 2'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another." [GOC:mah, PMID:8940112]
subset: gosubset_prok
synonym: "2'-5' RNA ligase activity" EXACT []
xref: EC:6.5.1.-
is_a: GO:0008452 ! RNA ligase activity

[Term]
id: GO:0008665
name: 2'-phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group from one compound to the 2' position of another." [GOC:jl, GOC:mah]
subset: gosubset_prok
xref: MetaCyc:2.7.1.160-RXN
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0008666
name: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate." [EC:2.3.1.117]
subset: gosubset_prok
synonym: "succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" EXACT [EC:2.3.1.117]
synonym: "succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" EXACT [EC:2.3.1.117]
synonym: "succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase activity" EXACT [EC:2.3.1.117]
synonym: "tetrahydrodipicolinate N-succinyltransferase activity" EXACT [EC:2.3.1.117]
synonym: "tetrahydrodipicolinate succinylase activity" EXACT [EC:2.3.1.117]
synonym: "tetrahydrodipicolinate succinyltransferase activity" EXACT [EC:2.3.1.117]
synonym: "tetrahydropicolinate succinylase activity" EXACT [EC:2.3.1.117]
xref: EC:2.3.1.117
xref: MetaCyc:TETHYDPICSUCC-RXN
is_a: GO:0016749 ! N-succinyltransferase activity

[Term]
id: GO:0008667
name: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+." [EC:1.3.1.28]
subset: gosubset_prok
synonym: "2,3-DHB dehydrogenase activity" EXACT [EC:1.3.1.28]
synonym: "2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.28]
xref: EC:1.3.1.28
xref: MetaCyc:DHBDEHYD-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008668
name: (2,3-dihydroxybenzoyl)adenylate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate = diphosphate + (2,3-dihydroxybenzoyl)adenylate." [EC:2.7.7.58, MetaCyc:2.7.7.58-RXN]
subset: gosubset_prok
synonym: "2,3-dihydroxybenzoate-AMP ligase activity" EXACT []
synonym: "ATP:2,3-dihydroxybenzoate adenylyltransferase activity" EXACT [EC:2.7.7.58]
xref: EC:2.7.7.58
xref: MetaCyc:DHBAMPLIG-RXN
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0008669
name: 2,3-dihydroxy-phenylpropionate 1,2-dioxygenase activity
namespace: molecular_function
xref: EC:1.13.11.-
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0008670
name: 2,4-dienoyl-CoA reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+." [EC:1.3.1.34]
subset: gosubset_prok
synonym: "4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.34]
synonym: "4-enoyl-CoA reductase (NADPH) activity" EXACT [EC:1.3.1.34]
synonym: "4-enoyl-CoA reductase (NADPH2)" EXACT [EC:1.3.1.34]
synonym: "4-enoyl-CoA reductase activity" EXACT [EC:1.3.1.34]
synonym: "trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.34]
xref: EC:1.3.1.34
xref: MetaCyc:DIENOYLCOAREDUCT-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008671
name: 2-dehydro-3-deoxygalactonokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-D-galactonate 6-phosphate." [EC:2.7.1.58]
subset: gosubset_prok
synonym: "2-keto-3-deoxy-galactonokinase activity" EXACT [EC:2.7.1.58]
synonym: "2-keto-3-deoxygalactonate kinase (phosphorylating)" EXACT [EC:2.7.1.58]
synonym: "2-keto-3-deoxygalactonokinase activity" EXACT [EC:2.7.1.58]
synonym: "2-oxo-3-deoxygalactonate kinase activity" EXACT [EC:2.7.1.58]
synonym: "ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase activity" EXACT [EC:2.7.1.58]
xref: EC:2.7.1.58
xref: MetaCyc:DEHYDDEOXGALACTKIN-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008672
name: 2-dehydro-3-deoxyglucarate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde." [EC:4.1.2.20]
subset: gosubset_prok
synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.20]
synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase activity" EXACT [EC:4.1.2.20]
synonym: "2-keto-3-deoxyglucarate aldolase activity" EXACT [EC:4.1.2.20]
synonym: "alpha-keto-beta-deoxy-D-glucarate aldolase activity" EXACT [EC:4.1.2.20]
xref: EC:4.1.2.20
xref: MetaCyc:KDGALDOL-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008673
name: 2-dehydro-3-deoxygluconokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + beta-L-arabinose 1-phosphate." [EC:2.7.1.45]
subset: gosubset_prok
synonym: "2-keto-3-deoxy-D-gluconic acid kinase activity" EXACT [EC:2.7.1.45]
synonym: "2-keto-3-deoxygluconate kinase activity" EXACT [EC:2.7.1.45]
synonym: "2-keto-3-deoxygluconokinase (phosphorylating)" EXACT [EC:2.7.1.45]
synonym: "2-keto-3-deoxygluconokinase activity" EXACT [EC:2.7.1.45]
synonym: "3-deoxy-2-oxo-D-gluconate kinase activity" EXACT [EC:2.7.1.45]
synonym: "ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.45]
synonym: "KDG kinase activity" EXACT [EC:2.7.1.45]
synonym: "ketodeoxygluconokinase activity" EXACT [EC:2.7.1.45]
xref: EC:2.7.1.45
xref: MetaCyc:DEOXYGLUCONOKIN-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008674
name: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.21]
subset: gosubset_prok
synonym: "(KDPGal)aldolase activity" EXACT [EC:4.1.2.21]
synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" EXACT [EC:4.1.2.21]
synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.21]
synonym: "2-dehydro-3-deoxyphosphogalactonate aldolase activity" EXACT []
synonym: "2-keto-3-deoxy-6-phosphogalactonic acid aldolase activity" EXACT [EC:4.1.2.21]
synonym: "2-keto-3-deoxy-6-phosphogalactonic aldolase activity" EXACT [EC:4.1.2.21]
synonym: "2-oxo-3-deoxygalactonate 6-phosphate aldolase activity" EXACT [EC:4.1.2.21]
synonym: "6-phospho-2-dehydro-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21]
synonym: "6-phospho-2-keto-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21]
synonym: "phospho-2-keto-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21]
synonym: "phospho-2-keto-3-deoxygalactonic aldolase activity" EXACT [EC:4.1.2.21]
xref: EC:4.1.2.21
xref: MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008675
name: 2-dehydro-3-deoxy-phosphogluconate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.14]
subset: gosubset_prok
synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" EXACT [EC:4.1.2.14]
synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.14]
synonym: "2-keto-3-deoxy-6-phosphogluconate aldolase activity" EXACT [EC:4.1.2.14]
synonym: "2-keto-3-deoxy-6-phosphogluconic aldolase activity" EXACT [EC:4.1.2.14]
synonym: "2-keto-3-deoxygluconate-6-P-aldolase activity" EXACT [EC:4.1.2.14]
synonym: "2-keto-3-deoxygluconate-6-phosphate aldolase activity" EXACT [EC:4.1.2.14]
synonym: "2-oxo-3-deoxy-6-phosphogluconate aldolase activity" EXACT [EC:4.1.2.14]
synonym: "6-phospho-2-keto-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14]
synonym: "KDPG aldolase activity" EXACT [EC:4.1.2.14]
synonym: "KDPG-aldolase activity" EXACT [EC:4.1.2.14]
synonym: "ODPG aldolase activity" EXACT [EC:4.1.2.14]
synonym: "phospho-2-dehydro-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14]
synonym: "phospho-2-keto-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14]
synonym: "phospho-2-keto-3-deoxygluconic aldolase activity" EXACT [EC:4.1.2.14]
xref: EC:4.1.2.14
xref: MetaCyc:KDPGALDOL-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008676
name: 3-deoxy-8-phosphooctulonate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate." [EC:2.5.1.55]
comment: Note that this function was formerly EC:4.1.2.16.
subset: gosubset_prok
synonym: "2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.55]
synonym: "2-dehydro-3-deoxy-phosphooctonate aldolase activity" EXACT [EC:2.5.1.55]
synonym: "2-dehydro-3-deoxyphosphooctonate aldolase activity" EXACT []
synonym: "2-keto-3-deoxy-8-phosphooctonic synthetase activity" EXACT [EC:2.5.1.55]
synonym: "3-deoxy-D-manno-octulosonate-8-phosphate synthase activity" EXACT [EC:2.5.1.55]
synonym: "3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase activity" EXACT [EC:2.5.1.55]
synonym: "3-deoxy-D-mannooctulosonate-8-phosphate synthetase activity" EXACT [EC:2.5.1.55]
synonym: "3-deoxyoctulosonic 8-phosphate synthetase activity" EXACT [EC:2.5.1.55]
synonym: "KDO-8-P synthase activity" EXACT [EC:2.5.1.55]
synonym: "KDO-8-phosphate synthetase activity" EXACT [EC:2.5.1.55]
synonym: "KDOP synthase activity" EXACT [EC:2.5.1.55]
synonym: "phospho-2-keto-3-deoxyoctonate aldolase activity" EXACT [EC:2.5.1.55]
synonym: "phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.55]
xref: EC:2.5.1.55
xref: MetaCyc:KDO-8PSYNTH-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0008677
name: 2-dehydropantoate 2-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+." [EC:1.1.1.169]
subset: gosubset_prok
synonym: "(R)-pantoate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.169]
synonym: "2-ketopantoate reductase activity" EXACT [EC:1.1.1.169]
synonym: "2-ketopantoic acid reductase activity" EXACT [EC:1.1.1.169]
synonym: "2-oxopantoate reductase activity" EXACT [EC:1.1.1.169]
synonym: "ketopantoate reductase activity" EXACT [EC:1.1.1.169]
synonym: "ketopantoic acid reductase activity" EXACT [EC:1.1.1.169]
synonym: "KPA reductase activity" EXACT [EC:1.1.1.169]
xref: EC:1.1.1.169
xref: MetaCyc:2-DEHYDROPANTOATE-REDUCT-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008678
name: 2-deoxy-D-gluconate 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+." [EC:1.1.1.125]
subset: gosubset_prok
synonym: "2-deoxy-D-gluconate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.125]
synonym: "2-deoxygluconate dehydrogenase activity" EXACT [EC:1.1.1.125]
synonym: "2-keto-3-deoxygluconate oxidoreductase activity" EXACT [EC:1.1.1.125]
xref: EC:1.1.1.125
xref: MetaCyc:KDUD-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008679
name: 2-hydroxy-3-oxopropionate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+." [EC:1.1.1.60]
subset: gosubset_prok
synonym: "(R)-glycerate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.60]
synonym: "tartronate semialdehyde reductase activity" EXACT [EC:1.1.1.60]
xref: EC:1.1.1.60
xref: MetaCyc:TSA-REDUCT-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008681
name: 2-octaprenyl-6-methoxyphenol hydroxylase activity
namespace: molecular_function
subset: gosubset_prok
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0008682
name: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone + O2 = 2-octoprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone." [MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN]
xref: MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0008683
name: 2-oxoglutarate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate = succinate semialdehyde + CO2." [EC:4.1.1.71]
subset: gosubset_prok
synonym: "2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming)" EXACT [EC:4.1.1.71]
synonym: "2-oxoglutarate carboxy-lyase activity" EXACT [EC:4.1.1.71]
synonym: "alpha-ketoglutarate decarboxylase activity" EXACT [EC:4.1.1.71]
synonym: "alpha-ketoglutaric decarboxylase activity" EXACT [EC:4.1.1.71]
synonym: "pre-2-oxoglutarate decarboxylase activity" EXACT [EC:4.1.1.71]
xref: EC:4.1.1.71
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008684
name: 2-oxopent-4-enoate hydratase activity
namespace: molecular_function
alt_id: GO:0018821
def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O." [EC:4.2.1.80]
subset: gosubset_prok
synonym: "2-keto-4-pentenoate (vinylpyruvate)hydratase activity" EXACT [EC:4.2.1.80]
synonym: "2-keto-4-pentenoate hydratase activity" EXACT [EC:4.2.1.80]
synonym: "4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)" EXACT [EC:4.2.1.80]
synonym: "4-hydroxy-2-oxopentanoate hydro-lyase activity" EXACT [EC:4.2.1.80]
synonym: "OEH activity" EXACT [EC:4.2.1.80]
xref: EC:4.2.1.80
xref: MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN
xref: UM-BBD_enzymeID:e0078
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008685
name: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP." [EC:4.6.1.12, GOC:mlg]
subset: gosubset_prok
synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing)" EXACT [EC:4.6.1.12]
synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)" EXACT [EC:4.6.1.12]
synonym: "MECDP-synthase activity" EXACT [EC:4.6.1.12]
synonym: "MECP synthase activity" EXACT []
xref: EC:4.6.1.12
xref: MetaCyc:RXN0-302
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0008686
name: 3,4-dihydroxy-2-butanone-4-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-phosphate + formate." [MetaCyc:DIOHBUTANONEPSYN-RXN]
subset: gosubset_prok
xref: EC:4.1.99.12
xref: MetaCyc:DIOHBUTANONEPSYN-RXN
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0008687
name: 3,4-dihydroxyphenylacetate 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde." [EC:1.13.11.15]
subset: gosubset_prok
synonym: "3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.15]
synonym: "3,4-dihydroxyphenylacetic acid 2,3-dioxygenase activity" EXACT [EC:1.13.11.15]
synonym: "homoprotocatechuate 2,3-dioxygenase activity" EXACT [EC:1.13.11.15]
synonym: "HPC dioxygenase activity" EXACT [EC:1.13.11.15]
xref: EC:1.13.11.15
xref: MetaCyc:1.13.11.15-RXN
xref: UM-BBD_enzymeID:e0125
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0008688
name: 3-(3-hydroxy-phenyl)propionate hydroxylase activity
namespace: molecular_function
xref: EC:1.14.13.-
xref: MetaCyc:MHPHYDROXY-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0008689
name: 3-demethylubiquinone-9 3-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9." [EC:2.1.1.64]
subset: gosubset_prok
synonym: "5-demethylubiquinone-9 methyltransferase activity" EXACT [EC:2.1.1.64]
synonym: "OMHMB-methyltransferase activity" EXACT [EC:2.1.1.64]
synonym: "S-adenosyl-L-methionine:2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone 3-O-methyltransferase activity" EXACT [EC:2.1.1.64]
synonym: "S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase activity" EXACT [EC:2.1.1.64]
xref: EC:2.1.1.64
xref: MetaCyc:DHHB-METHYLTRANSFER-RXN
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008690
name: 3-deoxy-manno-octulosonate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate." [EC:2.7.7.38]
subset: gosubset_prok
synonym: "2-keto-3-deoxyoctonate cytidylyltransferase activity" EXACT [EC:2.7.7.38]
synonym: "3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38]
synonym: "CMP-2-keto-3-deoxyoctulosonic acid synthetase activity" EXACT [EC:2.7.7.38]
synonym: "CMP-3-deoxy-D-manno-octulosonate diphosphorylase activity" EXACT [EC:2.7.7.38]
synonym: "CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" EXACT [EC:2.7.7.38]
synonym: "CMP-3-deoxy-D-manno-octulosonate synthetase activity" EXACT [EC:2.7.7.38]
synonym: "CMP-KDO synthetase activity" EXACT [EC:2.7.7.38]
synonym: "CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38]
synonym: "CTP:3-deoxy-manno-octulosonate cytidylyltransferase activity" EXACT []
synonym: "CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38]
synonym: "cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" EXACT [EC:2.7.7.38]
xref: EC:2.7.7.38
xref: MetaCyc:CPM-KDOSYNTH-RXN
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0008691
name: 3-hydroxybutyryl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+." [EC:1.1.1.157]
subset: gosubset_prok
synonym: "(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.157]
synonym: "beta-hydroxybutyryl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.157]
synonym: "beta-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157]
synonym: "BHBD activity" EXACT [EC:1.1.1.157]
synonym: "dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.157]
synonym: "L(+)-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157]
synonym: "L-(+)-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157]
xref: EC:1.1.1.157
xref: MetaCyc:3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008692
name: 3-hydroxybutyryl-CoA epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA." [EC:5.1.2.3]
subset: gosubset_prok
synonym: "3-hydroxyacyl-CoA epimerase activity" EXACT [EC:5.1.2.3]
synonym: "3-hydroxybutanoyl-CoA 3-epimerase activity" EXACT [EC:5.1.2.3]
synonym: "3-hydroxybutyryl coenzyme A epimerase activity" EXACT [EC:5.1.2.3]
xref: EC:5.1.2.3
xref: MetaCyc:OHBUTYRYL-COA-EPIM-RXN
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0008693
name: 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.60]
subset: gosubset_prok
synonym: "(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.60]
synonym: "3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity" EXACT []
synonym: "3-hydroxydecanoyl-ACP dehydratase activity" EXACT []
synonym: "3-hydroxydecanoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.60]
synonym: "3-hydroxydecanoyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.60]
synonym: "3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.60]
synonym: "beta-hydroxyacyl-ACP dehydrase activity" EXACT [EC:4.2.1.60]
synonym: "beta-hydroxyacyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.60]
synonym: "beta-hydroxydecanoate dehydrase activity" EXACT [EC:4.2.1.60]
synonym: "beta-hydroxydecanoyl thioester dehydrase activity" EXACT [EC:4.2.1.60]
synonym: "beta-hydroxydecanoyl thiol ester dehydrase activity" EXACT [EC:4.2.1.60]
synonym: "D-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity" EXACT [EC:4.2.1.60]
synonym: "D-3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.60]
synonym: "FabA" RELATED [EC:4.2.1.60]
synonym: "HDDase activity" EXACT [EC:4.2.1.60]
xref: EC:4.2.1.60
xref: MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN
is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity

[Term]
id: GO:0008694
name: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
namespace: molecular_function
alt_id: GO:0019167
def: "Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2." [MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN]
subset: gosubset_prok
synonym: "3-octaprenyl-4-hydroxybenzoate decarboxylase activity" EXACT []
synonym: "3-polyprenyl 4-hydroxybenzoate decarboxylase activity" EXACT []
synonym: "3-polyprenyl-4-hydroxybenzoate carboxy-lyase activity" EXACT []
synonym: "polyprenyl p-hydroxybenzoate decarboxylase activity" EXACT []
synonym: "PPHB decarboxylase activity" EXACT []
synonym: "UbiD" RELATED []
synonym: "UbiX" RELATED []
xref: EC:4.1.1.-
xref: MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008695
name: 3-phenylpropionate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol." [UM-BBD_enzymeID:e0307]
synonym: "3-phenylpropanoate dioxygenase activity" EXACT [EC:1.14.12.19]
synonym: "3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) activity" EXACT [EC:1.14.12.19]
synonym: "Hca dioxygenase activity" EXACT [EC:1.14.12.19]
synonym: "HcaA1A2CD" RELATED [EC:1.14.12.19]
xref: EC:1.14.12.19
xref: MetaCyc:HCAMULTI-RXN
xref: UM-BBD_enzymeID:e0307
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0008696
name: 4-amino-4-deoxychorismate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-amino-4-deoxychorismate = p-aminobenzoate + pyruvate." [MetaCyc:ADCLY-RXN]
comment: Note that the name 'para-amino benzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate.
subset: gosubset_prok
synonym: "4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)" EXACT [EC:4.1.3.38]
synonym: "4-amino-4-deoxychorismate pyruvate-lyase activity" EXACT [EC:4.1.3.38]
synonym: "ADC lyase activity" EXACT [EC:4.1.3.38]
synonym: "aminodeoxychorismate lyase activity" EXACT []
synonym: "enzyme X activity" RELATED [EC:4.1.3.38]
synonym: "p-aminobenzoate synthetase" RELATED []
synonym: "para-aminobenzoic acid (PABA) synthase" RELATED []
synonym: "para-aminobenzoic acid synthase" RELATED []
xref: EC:4.1.3.38
xref: MetaCyc:ADCLY-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008697
name: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-deoxy-L-threo-5-hexosulose uronate = 3-deoxy-D-glycero-2,5-hexodiulosonate." [EC:5.3.1.17]
subset: gosubset_prok
synonym: "4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.17]
synonym: "4-deoxy-L-threo-5-hexulose uronate isomerase activity" EXACT [EC:5.3.1.17]
synonym: "5-keto-4-deoxyuronate isomerase activity" EXACT [EC:5.3.1.17]
xref: EC:5.3.1.17
xref: MetaCyc:5.3.1.17-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008700
name: 4-hydroxy-2-oxoglutarate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate." [EC:4.1.3.16]
subset: gosubset_prok
synonym: "2-keto-4-hydroxybutyrate aldolase activity" EXACT [EC:4.1.3.16]
synonym: "2-keto-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16]
synonym: "2-keto-4-hydroxyglutaric aldolase activity" EXACT [EC:4.1.3.16]
synonym: "2-oxo-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16]
synonym: "2-oxo-4-hydroxyglutaric aldolase activity" EXACT [EC:4.1.3.16]
synonym: "4-hydroxy-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.16]
synonym: "4-hydroxy-2-ketoglutaric aldolase activity" EXACT [EC:4.1.3.16]
synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)" EXACT [EC:4.1.3.16]
synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase activity" EXACT [EC:4.1.3.16]
synonym: "DL-4-hydroxy-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.16]
synonym: "hydroxyketoglutarate aldolase activity" EXACT [EC:4.1.3.16]
synonym: "hydroxyketoglutaric aldolase activity" EXACT [EC:4.1.3.16]
synonym: "KHG-aldolase activity" EXACT [EC:4.1.3.16]
xref: EC:4.1.3.16
xref: MetaCyc:4OH2OXOGLUTARALDOL-RXN
is_a: GO:0016832 ! aldehyde-lyase activity
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008701
name: 4-hydroxy-2-oxovalerate aldolase activity
namespace: molecular_function
alt_id: GO:0018804
def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = pyruvate + acetaldehyde." [EC:4.1.3.39]
synonym: "4-hydroxy-2-ketovalerate aldolase activity" EXACT [EC:4.1.3.39]
synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) activity" EXACT [EC:4.1.3.39]
synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase activity" EXACT [EC:4.1.3.39]
synonym: "4-hydroxy-2-oxovalerate pyruvate-lyase activity" EXACT [EC:4.1.3.39]
synonym: "DmpG" RELATED [EC:4.1.3.39]
synonym: "HOA" RELATED [EC:4.1.3.39]
xref: EC:4.1.3.39
xref: MetaCyc:4.1.3.39-RXN
xref: MetaCyc:MHPELY-RXN
xref: UM-BBD_enzymeID:e0077
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008703
name: 5-amino-6-(5-phosphoribosylamino)uracil reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + NADPH + H+." [EC:1.1.1.193]
subset: gosubset_prok
synonym: "5-amino-6-(5'-phosphoribosylamino)uracil reductase activity" EXACT []
synonym: "5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase activity" EXACT [EC:1.1.1.193]
synonym: "aminodioxyphosphoribosylaminopyrimidine reductase activity" EXACT [EC:1.1.1.193]
xref: EC:1.1.1.193
xref: MetaCyc:RIBOFLAVINSYNREDUC-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008704
name: 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity
namespace: molecular_function
alt_id: GO:0018843
def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate." [EC:5.3.3.10]
subset: gosubset_prok
synonym: "2-hydroxyhepta-2,4-diene-1,7-dioate isomerase" RELATED []
synonym: "5-carboxymethyl-2-hydroxymuconate D-isomerase activity" EXACT []
synonym: "5-carboxymethyl-2-hydroxymuconate delta2,Delta4-2-oxo,Delta3-isomerase activity" EXACT [EC:5.3.3.10]
synonym: "5-carboxymethyl-2-hydroxymuconic acid isomerase activity" EXACT [EC:5.3.3.10]
synonym: "CHM isomerase activity" EXACT [EC:5.3.3.10]
synonym: "HHDD isomerase activity" EXACT []
synonym: "hpaG-1" RELATED []
synonym: "hpaG1" RELATED []
xref: EC:5.3.3.10
xref: MetaCyc:5.3.3.10-RXN
xref: UM-BBD_enzymeID:e0135
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0008705
name: methionine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine." [EC:2.1.1.13]
subset: gosubset_prok
synonym: "5-methyltetrahydrofolate--homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "5-methyltetrahydrofolate--homocysteine transmethylase activity" EXACT [EC:2.1.1.13]
synonym: "5-methyltetrahydrofolate-homocysteine S-methyltransferase activity" EXACT []
synonym: "5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "cobalamin-dependent methionine synthase activity" EXACT [EC:2.1.1.13]
synonym: "MetH" RELATED [EC:2.1.1.13]
synonym: "methionine synthase (cobalamin-dependent) activity" EXACT [EC:2.1.1.13]
synonym: "methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N(5)-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13]
synonym: "N-methyltetrahydrofolate:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N5-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13]
synonym: "tetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "tetrahydropteroylglutamate methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "tetrahydropteroylglutamic methyltransferase activity" EXACT [EC:2.1.1.13]
synonym: "vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13]
xref: EC:2.1.1.13
xref: MetaCyc:HOMOCYSMETB12-RXN
xref: Reactome:25894 "methionine synthase activity"
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0042084 ! 5-methyltetrahydrofolate-dependent methyltransferase activity

[Term]
id: GO:0008706
name: 6-phospho-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose." [EC:3.2.1.86]
subset: gosubset_prok
synonym: "6-phospho-beta-D-glucosyl-(1,4)-D-glucose glucohydrolase activity" EXACT [EC:3.2.1.86]
synonym: "phospho-beta-glucosidase A" RELATED [EC:3.2.1.86]
synonym: "phospho-beta-glucosidase activity" EXACT [EC:3.2.1.86]
synonym: "phosphocellobiase activity" EXACT [EC:3.2.1.86]
xref: EC:3.2.1.86
xref: MetaCyc:6-PHOSPHO-BETA-GLUCOSIDASE-RXN
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0008707
name: 4-phytase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate." [EC:3.1.3.26]
subset: gosubset_prok
synonym: "6-phytase (name based on 1L-numbering system and not 1D-numbering)" BROAD [EC:3.1.3.26]
synonym: "6-phytase activity" EXACT []
synonym: "myo-inositol-hexakisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.26]
synonym: "phytase activity" BROAD [EC:3.1.3.26]
synonym: "phytate 6-phosphatase activity" EXACT [EC:3.1.3.26]
xref: EC:3.1.3.26
xref: MetaCyc:6-PHYT-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0008709
name: 7-alpha-hydroxysteroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + NAD+ = 3-alpha,12-alpha-dihydroxy-7-oxo-5-beta-cholanate + NADH + H+." [EC:1.1.1.159]
subset: gosubset_prok
synonym: "7alpha-HSDH" RELATED [EC:1.1.1.159]
synonym: "7alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.159]
synonym: "7alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.159]
synonym: "7alpha-hydroxysteroid:NAD+ 7-oxidoreductase activity" EXACT [EC:1.1.1.159]
xref: EC:1.1.1.159
xref: MetaCyc:7-ALPHA-HYDROXYSTEROID-DEH-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008710
name: 8-amino-7-oxononanoate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-carboxyhexanoyl-CoA + L-alanine = 8-amino-7-oxononanoate + CoA + CO2." [EC:2.3.1.47]
subset: gosubset_prok
synonym: "6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating)" EXACT [EC:2.3.1.47]
synonym: "7-KAP synthetase activity" EXACT [EC:2.3.1.47]
synonym: "7-keto-8-amino-pelargonic acid synthetase activity" EXACT [EC:2.3.1.47]
synonym: "7-keto-8-aminopelargonic acid synthetase activity" EXACT [EC:2.3.1.47]
synonym: "7-keto-8-aminopelargonic synthetase activity" EXACT [EC:2.3.1.47]
synonym: "8-amino-7-ketopelargonate synthase activity" EXACT [EC:2.3.1.47]
synonym: "8-amino-7-oxopelargonate synthase activity" EXACT [EC:2.3.1.47]
synonym: "AONS activity" EXACT [EC:2.3.1.47]
xref: EC:2.3.1.47
xref: MetaCyc:7KAPSYN-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0008711
name: ADP-L-glycero-D-manno-heptose synthase activity
namespace: molecular_function
def: "OBSOLETE." [GOC:curators]
comment: This term was made obsolete because it represents a bifunctional gene product (e.g. E. coli RfaE).
is_obsolete: true
consider: GO:0033785
consider: GO:0033786

[Term]
id: GO:0008712
name: ADP-glyceromanno-heptose 6-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose." [EC:5.1.3.20]
subset: gosubset_prok
synonym: "ADP-L-glycero-D-manno-heptose 6-epimerase activity" EXACT [EC:5.1.3.20]
synonym: "ADPglyceromanno-heptose 6-epimerase activity" EXACT [EC:5.1.3.20]
xref: EC:5.1.3.20
xref: MetaCyc:5.1.3.20-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0008713
name: ADP-heptose-lipopolysaccharide heptosyltransferase activity
namespace: molecular_function
subset: gosubset_prok
is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity

[Term]
id: GO:0008714
name: AMP nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + H2O = adenine + D-ribose 5-phosphate." [EC:3.2.2.4]
subset: gosubset_prok
synonym: "adenosine monophosphate nucleosidase activity" EXACT [EC:3.2.2.4]
synonym: "adenylate nucleosidase activity" EXACT [EC:3.2.2.4]
synonym: "AMP phosphoribohydrolase activity" EXACT [EC:3.2.2.4]
xref: EC:3.2.2.4
xref: MetaCyc:AMP-NUCLEOSID-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0008715
name: CDP-diacylglycerol diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-diacylglycerol + H2O = CMP + phosphatidate." [EC:3.6.1.26]
subset: gosubset_prok
synonym: "CDP diacylglycerol hydrolase activity" EXACT [EC:3.6.1.26]
synonym: "CDP-diacylglycerol phosphatidylhydrolase activity" EXACT [EC:3.6.1.26]
synonym: "CDP-diacylglycerol pyrophosphatase activity" EXACT []
synonym: "cytidine diphosphodiacylglycerol pyrophosphatase activity" EXACT [EC:3.6.1.26]
xref: EC:3.6.1.26
xref: MetaCyc:CDPDIGLYPYPHOSPHA-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0008716
name: D-alanine-D-alanine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine." [EC:6.3.2.4]
subset: gosubset_prok
synonym: "alanine:alanine ligase (ADP-forming) activity" EXACT [EC:6.3.2.4]
synonym: "alanylalanine synthetase activity" EXACT [EC:6.3.2.4]
synonym: "D-Ala-D-Ala synthetase activity" EXACT [EC:6.3.2.4]
synonym: "D-alanine:D-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.4]
synonym: "D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.4]
synonym: "D-alanylalanine synthetase activity" EXACT [EC:6.3.2.4]
xref: EC:6.3.2.4
xref: MetaCyc:DALADALALIG-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008717
name: D-alanyl-D-alanine endopeptidase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "penicillin-binding protein 7" NARROW []
synonym: "penicillin-binding protein 8" NARROW []
xref: EC:3.4.99.-
is_obsolete: true
replaced_by: GO:0004175

[Term]
id: GO:0008718
name: D-amino-acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor." [EC:1.4.99.1]
subset: gosubset_prok
synonym: "D-amino-acid:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.1]
synonym: "D-amino-acid:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.1]
xref: EC:1.4.99.1
xref: MetaCyc:DAADEHYDROG-RXN
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0008719
name: dihydroneopterin triphosphate 2'-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate." [MetaCyc:H2NTPEPIM-RXN]
subset: gosubset_prok
synonym: "D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase activity" EXACT []
xref: EC:5.-.-.-
xref: MetaCyc:H2NTPEPIM-RXN
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0008720
name: D-lactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.28]
subset: gosubset_prok
synonym: "D-lactic acid dehydrogenase activity" EXACT [EC:1.1.1.28]
synonym: "D-lactic dehydrogenase activity" EXACT [EC:1.1.1.28]
xref: EC:1.1.1.28
xref: MetaCyc:DLACTDEHYDROGNAD-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008721
name: D-serine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-serine = pyruvate + NH3." [EC:4.3.1.18]
comment: Note that this function was formerly EC:4.3.1.14.
subset: gosubset_prok
synonym: "D-hydroxy amino acid dehydratase activity" BROAD [EC:4.3.1.18]
synonym: "D-hydroxyaminoacid dehydratase activity" EXACT [EC:4.3.1.18]
synonym: "D-serine ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.18]
synonym: "D-serine deaminase activity" EXACT [EC:4.3.1.18]
synonym: "D-serine dehydrase activity" EXACT [EC:4.3.1.18]
synonym: "D-serine dehydratase (deaminating) activity" EXACT [EC:4.3.1.18]
synonym: "D-serine dehydratase activity" EXACT [EC:4.3.1.18]
synonym: "D-serine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.18]
synonym: "D-serine hydrolase activity" EXACT [EC:4.3.1.18]
xref: EC:4.3.1.18
xref: MetaCyc:DSERDEAM-RXN
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0008724
name: DNA topoisomerase IV activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the ATP-independent breakage of DNA, followed by passage and rejoining. It also catalyzes the relaxation of supercoiled DNA, and the decatenation and unknotting of DNA in vivo." [EC:5.99.1.-, PMID:11274059]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0003918

[Term]
id: GO:0008725
name: DNA-3-methyladenine glycosylase I activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [EC:3.2.2.20, GOC:elh, PMID:10872450, PMID:9224623]
subset: gosubset_prok
synonym: "3-methyladenine DNA glycosylase I" RELATED [EC:3.2.2.20]
synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.20]
synonym: "deoxyribonucleate 3-methyladenine glycosidase I" RELATED [EC:3.2.2.20]
synonym: "DNA glycosidase I activity" RELATED [EC:3.2.2.20]
synonym: "DNA-3-methyladenine glycosidase I activity" EXACT [EC:3.2.2.20]
xref: EC:3.2.2.20
xref: MetaCyc:3.2.2.20-RXN
is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity

[Term]
id: GO:0008726
name: alkanesulfonate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + SO3(2-) (sulfite) + H2O + FMN." [MetaCyc:RXN0-280]
subset: gosubset_prok
synonym: "alkanesulfonate, reduced-FMN:oxygen oxidoreductase activity" EXACT [EC:1.14.14.5]
synonym: "alkanesulphonate monooxygenase activity" EXACT []
synonym: "FMNH(2)-dependent aliphatic sulfonate monooxygenase activity" EXACT [EC:1.14.14.5]
synonym: "FMNH(2)-dependent alkanesulfonate monooxygenase activity" EXACT []
synonym: "FMNH2-dependent aliphatic sulfonate monooxygenase activity" EXACT [EC:1.14.14.5]
synonym: "SsuD" RELATED [EC:1.14.14.5]
synonym: "sulfate starvation-induced protein 6 activity" RELATED [EC:1.14.14.5]
xref: EC:1.14.14.5
xref: MetaCyc:RXN0-280
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0008727
name: GDP-mannose mannosyl hydrolase activity
namespace: molecular_function
xref: MetaCyc:GDPMANMANHYDRO-RXN
is_a: GO:0015923 ! mannosidase activity

[Term]
id: GO:0008728
name: GTP diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate." [EC:2.7.6.5]
subset: gosubset_prok
synonym: "(p)ppGpp synthetase I" RELATED [EC:2.7.6.5]
synonym: "(p)ppGpp synthetase II" RELATED [EC:2.7.6.5]
synonym: "ATP-GTP 3'-diphosphotransferase activity" EXACT [EC:2.7.6.5]
synonym: "ATP:GTP 3'-diphosphotransferase activity" EXACT [EC:2.7.6.5]
synonym: "GPSI" RELATED [EC:2.7.6.5]
synonym: "GPSII" RELATED [EC:2.7.6.5]
synonym: "GTP pyrophosphokinase activity" EXACT []
synonym: "guanosine 3',5'-polyphosphate synthase activity" EXACT [EC:2.7.6.5]
synonym: "guanosine 5',3'-polyphosphate synthetase activity" EXACT [EC:2.7.6.5]
synonym: "guanosine pentaphosphate synthetase activity" EXACT [EC:2.7.6.5]
synonym: "ppGpp synthetase I activity" EXACT [EC:2.7.6.5]
synonym: "stringent factor activity" RELATED [EC:2.7.6.5]
xref: EC:2.7.6.5
xref: MetaCyc:GTPPYPHOSKIN-RXN
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0008730
name: L(+)-tartrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R,R)-tartrate = oxaloacetate + H2O." [EC:4.2.1.32]
subset: gosubset_prok
synonym: "(R,R)-tartrate hydro-lyase (oxaloacetate-forming)" EXACT [EC:4.2.1.32]
synonym: "(R,R)-tartrate hydro-lyase activity" EXACT [EC:4.2.1.32]
synonym: "L-(+)-tartaric acid dehydratase activity" EXACT [EC:4.2.1.32]
synonym: "L-tartrate dehydratase activity" EXACT [EC:4.2.1.32]
synonym: "tartaric acid dehydrase activity" EXACT [EC:4.2.1.32]
synonym: "tartrate dehydratase activity" EXACT [EC:4.2.1.32]
xref: EC:4.2.1.32
xref: MetaCyc:LTARTDEHYDRA-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008732
name: L-allo-threonine aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde." [MetaCyc:LTAA-RXN, PMID:9228760]
subset: gosubset_prok
synonym: "L-allo-threonine acetaldehyde-lyase activity" EXACT []
synonym: "LtaA" RELATED []
xref: EC:4.1.2.-
xref: MetaCyc:LTAA-RXN
is_a: GO:0004793 ! threonine aldolase activity

[Term]
id: GO:0008733
name: L-arabinose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinose = L-ribulose." [EC:5.3.1.4]
subset: gosubset_prok
synonym: "L-arabinose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.4]
synonym: "L-arabinose ketol-isomerase activity" EXACT [EC:5.3.1.4]
xref: EC:5.3.1.4
xref: MetaCyc:ARABISOM-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008734
name: L-aspartate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2." [EC:1.4.3.16]
subset: gosubset_prok
synonym: "L-aspartate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.16]
xref: EC:1.4.3.16
xref: MetaCyc:L-ASPARTATE-OXID-RXN
xref: MetaCyc:RXN-9772
is_a: GO:0015922 ! aspartate oxidase activity

[Term]
id: GO:0008735
name: carnitine dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-carnitine = 4-(trimethylammonio)but-2-enoate + H2O." [EC:4.2.1.89]
subset: gosubset_prok
synonym: "L-carnitine dehydratase activity" EXACT []
synonym: "L-carnitine hydro-lyase [4-(trimethylammonio)but-2-enoate-forming]" RELATED [EC:4.2.1.89]
synonym: "L-carnitine hydro-lyase activity" EXACT [EC:4.2.1.89]
xref: EC:4.2.1.89
xref: MetaCyc:CARNDEHYDRA-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008736
name: L-fucose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-fucose = L-fuculose." [EC:5.3.1.25]
subset: gosubset_prok
synonym: "L-fucose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.25]
synonym: "L-fucose ketol-isomerase activity" EXACT [EC:5.3.1.25]
xref: EC:5.3.1.25
xref: MetaCyc:FUCISOM-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008737
name: L-fuculokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-fuculose = ADP + L-fuculose 1-phosphate." [EC:2.7.1.51]
subset: gosubset_prok
synonym: "ATP:L-fuculose 1-phosphotransferase activity" EXACT [EC:2.7.1.51]
synonym: "L-fuculokinase (phosphorylating)" EXACT [EC:2.7.1.51]
synonym: "L-fuculose kinase activity" EXACT [EC:2.7.1.51]
xref: EC:2.7.1.51
xref: MetaCyc:FUCULOKIN-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008738
name: L-fuculose-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde." [EC:4.1.2.17]
subset: gosubset_prok
synonym: "fuculose aldolase activity" EXACT [EC:4.1.2.17]
synonym: "L-fuculose 1-phosphate aldolase activity" EXACT [EC:4.1.2.17]
synonym: "L-fuculose-1-phosphate lactaldehyde-lyase activity" EXACT [EC:4.1.2.17]
synonym: "L-fuculose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.17]
xref: EC:4.1.2.17
xref: MetaCyc:FUCPALDOL-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008740
name: L-rhamnose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-rhamnose = L-rhamnulose." [EC:5.3.1.14]
subset: gosubset_prok
synonym: "L-rhamnose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.14]
synonym: "L-rhamnose ketol-isomerase activity" EXACT [EC:5.3.1.14]
synonym: "rhamnose isomerase activity" EXACT [EC:5.3.1.14]
xref: EC:5.3.1.14
xref: MetaCyc:RHAMNISOM-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008741
name: ribulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate." [EC:2.7.1.16]
subset: gosubset_prok
synonym: "ATP:L(or D)-ribulose 5-phosphotransferase activity" EXACT [EC:2.7.1.16]
synonym: "L-ribulokinase activity" EXACT []
synonym: "ribulokinase (phosphorylating)" EXACT [EC:2.7.1.16]
xref: EC:2.7.1.16
xref: MetaCyc:RIBULOKIN-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008742
name: L-ribulose-phosphate 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ribulose 5-phosphate = D-xylose 5-phosphate." [EC:5.1.3.4]
subset: gosubset_prok
synonym: "AraD" RELATED [EC:5.1.3.4]
synonym: "L-ribulose 5-phosphate 4-epimerase activity" EXACT [EC:5.1.3.4]
synonym: "L-ribulose-5-phosphate 4-epimerase" BROAD [EC:5.1.3.4]
synonym: "L-Ru5P" RELATED [EC:5.1.3.4]
synonym: "L-ru5P activity" EXACT [EC:5.1.3.4]
synonym: "phosphoribulose isomerase activity" EXACT [EC:5.1.3.4]
synonym: "ribulose phosphate 4-epimerase activity" EXACT [EC:5.1.3.4]
xref: EC:5.1.3.4
xref: MetaCyc:RIBULPEPIM-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0008743
name: L-threonine 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+." [EC:1.1.1.103]
subset: gosubset_prok
synonym: "L-threonine dehydrogenase activity" EXACT [EC:1.1.1.103]
synonym: "L-threonine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.103]
synonym: "threonine 3-dehydrogenase activity" BROAD []
synonym: "threonine dehydrogenase activity" EXACT [EC:1.1.1.103]
xref: EC:1.1.1.103
xref: MetaCyc:THREODEHYD-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008744
name: L-xylulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate." [EC:2.7.1.53]
subset: gosubset_prok
synonym: "ATP:L-xylulose 5-phosphotransferase activity" EXACT [EC:2.7.1.53]
synonym: "L-xylulokinase (phosphorylating)" EXACT [EC:2.7.1.53]
synonym: "L-xylulose kinase activity" EXACT [EC:2.7.1.53]
xref: EC:2.7.1.53
xref: MetaCyc:LYXK-RXN
is_a: GO:0004856 ! xylulokinase activity

[Term]
id: GO:0008745
name: N-acetylmuramoyl-L-alanine amidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28]
subset: gosubset_prok
synonym: "acetylmuramoyl-alanine amidase activity" EXACT [EC:3.5.1.28]
synonym: "acetylmuramyl-alanine amidase activity" EXACT [EC:3.5.1.28]
synonym: "acetylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28]
synonym: "murein hydrolase activity" EXACT [EC:3.5.1.28]
synonym: "N-acetylmuramic acid L-alanine amidase activity" EXACT [EC:3.5.1.28]
synonym: "N-acetylmuramoyl-L-alanine amidase type I" RELATED [EC:3.5.1.28]
synonym: "N-acetylmuramoyl-L-alanine amidase type II" RELATED [EC:3.5.1.28]
synonym: "N-acetylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28]
synonym: "N-acetylmuramylalanine amidase activity" EXACT [EC:3.5.1.28]
synonym: "N-acylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28]
synonym: "peptidoglycan amidohydrolase activity" EXACT [EC:3.5.1.28]
xref: EC:3.5.1.28
xref: MetaCyc:3.5.1.28-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008746
name: NAD(P) transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+." [EC:1.6.1.1, EC:1.6.1.2]
subset: gosubset_prok
synonym: "energy-linked transhydrogenase" EXACT [EC:1.6.1.1, EC:1.6.1.2]
synonym: "H+-thase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1, EC:1.6.1.2]
xref: EC:1.6.1.-
is_a: GO:0016652 ! oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor

[Term]
id: GO:0008747
name: N-acetylneuraminate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate." [EC:4.1.3.3]
subset: gosubset_prok
synonym: "acetylneuraminate lyase activity" EXACT [EC:4.1.3.3]
synonym: "acetylneuraminate pyruvate-lyase activity" EXACT [EC:4.1.3.3]
synonym: "N-acetylneuraminate aldolase activity" EXACT [EC:4.1.3.3]
synonym: "N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)" EXACT [EC:4.1.3.3]
synonym: "N-acetylneuraminate pyruvate-lyase activity" EXACT [EC:4.1.3.3]
synonym: "N-acetylneuraminic acid aldolase activity" EXACT [EC:4.1.3.3]
synonym: "N-acetylneuraminic acid lyase activity" EXACT [EC:4.1.3.3]
synonym: "N-acetylneuraminic aldolase activity" EXACT [EC:4.1.3.3]
synonym: "N-acetylneuraminic lyase activity" EXACT [EC:4.1.3.3]
synonym: "NALase activity" EXACT [EC:4.1.3.3]
synonym: "NANA lyase activity" EXACT [EC:4.1.3.3]
synonym: "neuraminate aldolase activity" EXACT [EC:4.1.3.3]
synonym: "neuraminic acid aldolase activity" EXACT [EC:4.1.3.3]
synonym: "neuraminic aldolase activity" EXACT [EC:4.1.3.3]
synonym: "NPL" RELATED [EC:4.1.3.3]
synonym: "sialate lyase activity" EXACT [EC:4.1.3.3]
synonym: "sialic acid aldolase activity" EXACT [EC:4.1.3.3]
synonym: "sialic aldolase activity" EXACT [EC:4.1.3.3]
xref: EC:4.1.3.3
xref: MetaCyc:ACNEULY-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008748
name: N-ethylmaleimide reductase activity
namespace: molecular_function
subset: gosubset_prok
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0008750
name: NAD(P)+ transhydrogenase (AB-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+." [EC:1.6.1.2, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf?sessid=6006l3]
subset: gosubset_prok
synonym: "NAD(P) transhydrogenase (AB-specific) activity" EXACT [EC:1.6.1.2]
synonym: "NADPH:NAD+ oxidoreductase (AB-specific)" EXACT [EC:1.6.1.2]
synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.2]
synonym: "transhydrogenase activity" BROAD [EC:1.6.1.2]
xref: EC:1.6.1.2
xref: MetaCyc:1.6.1.2-RXN
is_a: GO:0008746 ! NAD(P) transhydrogenase activity

[Term]
id: GO:0008751
name: NAD(P)H dehydrogenase
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it is a redundant grouping term with only one child.
is_obsolete: true
consider: GO:0016651

[Term]
id: GO:0008752
name: FMN reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+." [EC:1.5.1.29]
subset: gosubset_prok
synonym: "flavin mononucleotide reductase activity" EXACT [EC:1.5.1.29]
synonym: "flavine mononucleotide reductase activity" EXACT [EC:1.5.1.29]
synonym: "FMNH2:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "NAD(P)H dehydrogenase (FMN) activity" EXACT []
synonym: "NAD(P)H(2) dehydrogenase (FMN) activity" EXACT [EC:1.5.1.29]
synonym: "NAD(P)H(2):FMN oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "NAD(P)H-dependent FMN reductase activity" EXACT [EC:1.5.1.29]
synonym: "NAD(P)H-FMN reductase activity" EXACT [EC:1.5.1.29]
synonym: "NAD(P)H2 dehydrogenase (FMN)" EXACT [EC:1.5.1.29]
synonym: "NAD(P)H2:FMN oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "NAD(P)H:flavin oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "NAD(P)H:FMN oxidoreductase activity" EXACT [EC:1.5.1.29]
synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide (phosphate)) reductase activity" EXACT [EC:1.5.1.29]
synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.29]
synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.29]
synonym: "SsuE" RELATED [EC:1.5.1.29]
xref: EC:1.5.1.29
xref: MetaCyc:FMNREDUCT-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008753
name: NADPH dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor." [EC:1.6.99.6]
subset: gosubset_prok
synonym: "NADPH oxidase" BROAD [EC:1.6.99.6]
synonym: "NADPH:(quinone-acceptor) oxidoreductase" EXACT [EC:1.6.99.6]
synonym: "reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase" EXACT [EC:1.6.99.6]
xref: EC:1.6.99.6
xref: MetaCyc:NADPH-DEHYDROGENASE-QUINONE-RXN
is_a: GO:0003959 ! NADPH dehydrogenase activity

[Term]
id: GO:0008754
name: O antigen ligase activity
namespace: molecular_function
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0008755
name: O antigen polymerase activity
namespace: molecular_function
def: "Catalysis of the polymerization of o-antigen chains. O-antigens are tetra and penta saccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "O-antigen polymerase activity" EXACT []
xref: EC:2.4.1.-
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0008756
name: o-succinylbenzoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + O-succinylbenzoate + CoA = AMP + diphosphate + O-succinylbenzoyl-CoA." [EC:6.2.1.26]
subset: gosubset_prok
synonym: "2-succinylbenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.26]
synonym: "o-succinylbenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.26]
synonym: "o-succinylbenzoyl-CoA synthetase activity" EXACT [EC:6.2.1.26]
synonym: "o-succinylbenzoyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.26]
synonym: "OSB-CoA synthetase activity" EXACT [EC:6.2.1.26]
synonym: "osb-CoA synthetase activity" EXACT [EC:6.2.1.26]
xref: EC:6.2.1.26
xref: MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-RXN
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0008757
name: S-adenosylmethionine-dependent methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah]
subset: gosubset_prok
synonym: "S-adenosyl methionine-dependent methyltransferase activity" EXACT []
synonym: "SAM-dependent methyltransferase activity" EXACT []
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0008758
name: UDP-2,3-diacylglucosamine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP." [MetaCyc:LIPIDXSYNTHESIS-RXN, PMID:12000770]
subset: gosubset_prok
xref: EC:3.6.1.-
xref: MetaCyc:LIPIDXSYNTHESIS-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0008759
name: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
namespace: molecular_function
def: "Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine." [PMID:10026271]
subset: gosubset_prok
xref: EC:3.5.1.-
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0008760
name: UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine." [EC:2.5.1.7]
subset: gosubset_prok
synonym: "enoylpyruvate transferase activity" EXACT [EC:2.5.1.7]
synonym: "MurA transferase activity" NARROW [EC:2.5.1.7]
synonym: "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase activity" EXACT [EC:2.5.1.7]
synonym: "phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase activity" EXACT [EC:2.5.1.7]
synonym: "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase activity" EXACT [EC:2.5.1.7]
synonym: "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase activity" EXACT [EC:2.5.1.7]
synonym: "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase activity" EXACT [EC:2.5.1.7]
synonym: "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase activity" EXACT [EC:2.5.1.7]
synonym: "pyruvate-UDP-acetylglucosamine transferase activity" EXACT [EC:2.5.1.7]
synonym: "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase activity" EXACT [EC:2.5.1.7]
synonym: "pyruvate-uridine diphospho-N-acetylglucosamine transferase activity" EXACT [EC:2.5.1.7]
synonym: "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase activity" EXACT [EC:2.5.1.7]
synonym: "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase activity" EXACT [EC:2.5.1.7]
synonym: "UDP-N-acetylglucosamine enoylpyruvyltransferase activity" EXACT [EC:2.5.1.7]
xref: EC:2.5.1.7
xref: MetaCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0008761
name: UDP-N-acetylglucosamine 2-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine." [EC:5.1.3.14]
subset: gosubset_prok
synonym: "UDP-GlcNAc-2-epimerase activity" EXACT [EC:5.1.3.14]
synonym: "UDP-N-acetyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.14]
synonym: "UDP-N-acetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14]
synonym: "uridine diphosphate-N-acetylglucosamine-2'-epimerase activity" EXACT [EC:5.1.3.14]
synonym: "uridine diphospho-N-acetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14]
synonym: "uridine diphosphoacetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14]
xref: EC:5.1.3.14
xref: MetaCyc:UDPGLCNACEPIM-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0008762
name: UDP-N-acetylmuramate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158]
subset: gosubset_prok
synonym: "MurB reductase" RELATED [EC:1.1.1.158]
synonym: "UDP-GlcNAc-enoylpyruvate reductase activity" EXACT [EC:1.1.1.158]
synonym: "UDP-N-acetylenolpyruvoylglucosamine reductase activity" EXACT [EC:1.1.1.158]
synonym: "UDP-N-acetylglucosamine-enoylpyruvate reductase activity" EXACT [EC:1.1.1.158]
synonym: "UDP-N-acetylmuramate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.158]
synonym: "uridine diphospho-N-acetylglucosamine-enolpyruvate reductase activity" EXACT [EC:1.1.1.158]
synonym: "uridine diphosphoacetylpyruvoylglucosamine reductase activity" EXACT [EC:1.1.1.158]
synonym: "uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase activity" EXACT [EC:1.1.1.158]
xref: EC:1.1.1.158
xref: MetaCyc:UDPNACETYLMURAMATEDEHYDROG-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008763
name: UDP-N-acetylmuramate-L-alanine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine." [EC:6.3.2.8]
subset: gosubset_prok
synonym: "alanine-adding enzyme activity" RELATED [EC:6.3.2.8]
synonym: "L-Ala ligase activity" RELATED [EC:6.3.2.8]
synonym: "L-alanine-adding enzyme activity" RELATED [EC:6.3.2.8]
synonym: "MurC synthetase activity" NARROW [EC:6.3.2.8]
synonym: "UDP-acetylmuramyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8]
synonym: "UDP-MurNAc:L-alanine ligase activity" EXACT [EC:6.3.2.8]
synonym: "UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.8]
synonym: "UDP-N-acetylmuramoyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8]
synonym: "UDP-N-acetylmuramoylalanine synthetase activity" EXACT [EC:6.3.2.8]
synonym: "UDP-N-acetylmuramyl:L-alanine ligase activity" EXACT [EC:6.3.2.8]
synonym: "UDPMurNAc-L-alanine synthetase activity" EXACT [EC:6.3.2.8]
synonym: "uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8]
synonym: "uridine diphosphate N-acetylmuramate:L-alanine ligase activity" EXACT [EC:6.3.2.8]
synonym: "uridine diphospho-N-acetylmuramoylalanine synthetase activity" EXACT [EC:6.3.2.8]
synonym: "uridine-diphosphate-N-acetylmuramate:L-alanine ligase activity" EXACT [EC:6.3.2.8]
xref: EC:6.3.2.8
xref: MetaCyc:UDP-NACMUR-ALA-LIG-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008764
name: UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate." [EC:6.3.2.9]
subset: gosubset_prok
synonym: "D-glutamate ligase activity" RELATED [EC:6.3.2.9]
synonym: "D-glutamate-adding enzyme activity" RELATED [EC:6.3.2.9]
synonym: "MurD synthetase activity" EXACT [EC:6.3.2.9]
synonym: "UDP-Mur-NAC-L-Ala:D-Glu ligase activity" EXACT [EC:6.3.2.9]
synonym: "UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming)" EXACT [EC:6.3.2.9]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase activity" EXACT [EC:6.3.2.9]
synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase activity" EXACT [EC:6.3.2.9]
xref: EC:6.3.2.9
xref: MetaCyc:UDP-NACMURALA-GLU-LIG-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008765
name: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate." [EC:6.3.2.13]
subset: gosubset_prok
synonym: "MurE synthetase activity" RELATED [EC:6.3.2.13]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.13]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming) activity" EXACT [EC:6.3.2.13]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase activity" EXACT [EC:6.3.2.13]
synonym: "UDP-N-acetylmuramyl-tripeptide synthetase activity" EXACT [EC:6.3.2.13]
xref: EC:6.3.2.13
xref: MetaCyc:UDP-NACMURALGLDAPLIG-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008766
name: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine." [EC:6.3.2.15]
comment: Note that EC:6.3.2.15 was deleted from EC as the reaction is performed by UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (EC:6.3.2.10).
subset: gosubset_prok
xref: EC:6.3.2.-
xref: MetaCyc:UDP-NACMURALGLDAPAALIG-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008767
name: UDP-galactopyranose mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose." [EC:5.4.99.9]
subset: gosubset_prok
synonym: "UDP-D-galactopyranose furanomutase activity" EXACT [EC:5.4.99.9]
synonym: "UDPgalactopyranose mutase activity" EXACT [EC:5.4.99.9]
xref: EC:5.4.99.9
xref: MetaCyc:GALPMUT-RXN
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0008768
name: UDP-sugar diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate." [EC:3.6.1.45]
subset: gosubset_prok
synonym: "nucleosidediphosphate-sugar diphosphatase activity" EXACT [EC:3.6.1.45]
synonym: "nucleosidediphosphate-sugar pyrophosphatase activity" EXACT [EC:3.6.1.45]
synonym: "UDP-sugar hydrolase activity" EXACT [EC:3.6.1.45]
synonym: "UDP-sugar pyrophosphatase activity" EXACT [EC:3.6.1.45]
synonym: "UDP-sugar sugarphosphohydrolase activity" EXACT [EC:3.6.1.45]
xref: EC:3.6.1.45
xref: MetaCyc:UDPSUGARHYDRO-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0008769
name: X-His dipeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-His dipeptides." [EC:3.4.13.3]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "aminoacyl-histidine dipeptidase activity" EXACT [EC:3.4.13.3]
synonym: "aminoacylhistidine dipeptidase activity" EXACT [EC:3.4.13.3]
synonym: "carnosinase activity" RELATED [EC:3.4.13.3]
synonym: "dipeptidase M" RELATED [EC:3.4.13.3]
synonym: "homocarnosinase activity" RELATED [EC:3.4.13.3]
synonym: "Xaa-His dipeptidase activity" EXACT []
xref: EC:3.4.13.3
xref: MetaCyc:3.4.13.3-RXN
is_obsolete: true
replaced_by: GO:0008235
replaced_by: GO:0016805

[Term]
id: GO:0008770
name: [acyl-carrier-protein] phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein." [EC:3.1.4.14]
subset: gosubset_prok
synonym: "[acyl-carrier protein] phosphodiesterase activity" EXACT []
synonym: "[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14]
synonym: "ACP hydrolyase activity" EXACT [EC:3.1.4.14]
synonym: "ACP phosphodiesterase activity" EXACT []
synonym: "AcpH" RELATED [EC:3.1.4.14]
synonym: "acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14]
synonym: "acyl-carrier-protein phosphodiesterase activity" EXACT [EC:3.1.4.14]
synonym: "holo-acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14]
xref: EC:3.1.4.14
xref: MetaCyc:3.1.4.14-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0008771
name: [citrate (pro-3S)-lyase] ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form)." [EC:6.2.1.22]
subset: gosubset_prok
synonym: "acetate: SH-acyl-carrier-protein enzyme ligase (AMP)" EXACT [EC:6.2.1.22]
synonym: "acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming)" BROAD [EC:6.2.1.22]
synonym: "acetate:HS-citrate lyase ligase activity" EXACT [EC:6.2.1.22]
synonym: "citrate (pro-3S)-lyase ligase activity" EXACT [EC:6.2.1.22]
synonym: "citrate lyase ligase activity" EXACT [EC:6.2.1.22]
synonym: "citrate lyase synthetase activity" EXACT [EC:6.2.1.22]
xref: EC:6.2.1.22
xref: MetaCyc:CITC-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0008772
name: [isocitrate dehydrogenase (NADP+)] kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate." [EC:2.7.11.5]
subset: gosubset_prok
synonym: "ATP:isocitrate dehydrogenase (NADP+) phosphotransferase activity" EXACT [EC:2.7.11.5]
synonym: "ICDH kinase/phosphatase activity" EXACT [EC:2.7.11.5]
synonym: "IDH kinase activity" EXACT [EC:2.7.11.5]
synonym: "IDH kinase/phosphatase activity" EXACT [EC:2.7.11.5]
synonym: "IDH-K/P" RELATED [EC:2.7.11.5]
synonym: "IDHK/P" RELATED [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase (NADP) kinase activity" EXACT [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase (NADP+) kinase activity" EXACT [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase kinase activity" EXACT [EC:2.7.11.5]
synonym: "isocitrate dehydrogenase kinase/phosphatase activity" EXACT [EC:2.7.11.5]
synonym: "STK3" RELATED [EC:2.7.11.5]
xref: EC:2.7.11.5
xref: MetaCyc:PHOSICITDEHASE-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0008773
name: [protein-PII] uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII)." [EC:2.7.7.59]
subset: gosubset_prok
synonym: "PII uridylyl-transferase activity" EXACT [EC:2.7.7.59]
synonym: "protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59]
synonym: "uridyl removing enzyme" RELATED [EC:2.7.7.59]
synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.59]
synonym: "UTP:[protein-PII] uridylyltransferase activity" EXACT []
synonym: "UTP:protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59]
xref: EC:2.7.7.59
xref: MetaCyc:URITRANS-RXN
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0008774
name: acetaldehyde dehydrogenase (acetylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+." [EC:1.2.1.10]
subset: gosubset_prok
synonym: "acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.1.10]
synonym: "acylating acetaldehyde dehydrogenase activity" EXACT [EC:1.2.1.10]
synonym: "ADA" RELATED [EC:1.2.1.10]
synonym: "aldehyde dehydrogenase (acylating) activity" EXACT [EC:1.2.1.10]
synonym: "DmpF" RELATED [EC:1.2.1.10]
xref: EC:1.2.1.10
xref: MetaCyc:ACETALD-DEHYDROG-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008775
name: acetate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA." [EC:2.8.3.8]
subset: gosubset_prok
synonym: "acetate coenzyme A-transferase activity" EXACT [EC:2.8.3.8]
synonym: "acetyl-CoA:acetoacetate CoA transferase activity" EXACT [EC:2.8.3.8]
synonym: "acyl-CoA:acetate CoA-transferase activity" EXACT [EC:2.8.3.8]
synonym: "butyryl CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.8]
synonym: "butyryl coenzyme A transferase activity" EXACT [EC:2.8.3.8]
synonym: "succinyl-CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.8]
xref: EC:2.8.3.8
xref: MetaCyc:ACECOATRANS-RXN
xref: UM-BBD_enzymeID:e0012
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0008776
name: acetate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate." [EC:2.7.2.1]
subset: gosubset_prok
synonym: "acetate kinase (phosphorylating) activity" EXACT [EC:2.7.2.1]
synonym: "acetic kinase activity" EXACT [EC:2.7.2.1]
synonym: "acetokinase activity" EXACT [EC:2.7.2.1]
synonym: "AckA" RELATED [EC:2.7.2.1]
synonym: "AK activity" EXACT [EC:2.7.2.1]
synonym: "ATP:acetate phosphotransferase activity" EXACT [EC:2.7.2.1]
xref: EC:2.7.2.1
xref: MetaCyc:ACETATEKIN-RXN
xref: UM-BBD_enzymeID:e0031
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0008777
name: acetylornithine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine." [EC:3.5.1.16]
subset: gosubset_prok
synonym: "2-N-acetyl-L-ornithine amidohydrolase activity" EXACT [EC:3.5.1.16]
synonym: "acetylornithinase activity" BROAD [EC:3.5.1.16]
synonym: "N-acetylornithinase activity" BROAD [EC:3.5.1.16]
synonym: "N2-acetyl-L-ornithine amidohydrolase activity" EXACT [EC:3.5.1.16]
xref: EC:3.5.1.16
xref: MetaCyc:ACETYLORNDEACET-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0008779
name: acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine." [EC:2.3.1.40]
synonym: "acyl-[acyl-carrier protein]-phospholipid O-acyltransferase activity" EXACT []
synonym: "acyl-ACP-phospholipid O-acyltransferase activity" EXACT []
synonym: "acyl-acyl-carrier-protein-phospholipid O-acyltransferase activity" EXACT [EC:2.3.1.40]
synonym: "acyl-acyl-carrier-protein:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase activity" EXACT [EC:2.3.1.40]
xref: EC:2.3.1.40
xref: MetaCyc:ACYLGPEACYLTRANS-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0008780
name: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine." [EC:2.3.1.129]
subset: gosubset_prok
synonym: "(R)-3-hydroxytetradecanoyl-acyl-carrier-protein:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase activity" EXACT [EC:2.3.1.129]
synonym: "acyl-[acyl-carrier protein]-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT []
synonym: "acyl-ACP-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT []
synonym: "acyl-acyl-carrier-protein-UDP-N-acetylglucosamine O-acyltransferase" BROAD [EC:2.3.1.129]
synonym: "UDP-N-acetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129]
synonym: "uridine diphosphoacetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129]
xref: EC:2.3.1.129
xref: MetaCyc:UDPNACETYLGLUCOSAMACYLTRANS-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0008781
name: N-acylneuraminate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate." [EC:2.7.7.43]
subset: gosubset_prok
synonym: "acetylneuraminate cytidylyltransferase activity" EXACT [EC:2.7.7.43]
synonym: "acylneuraminate cytidyltransferase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-N-acetylneuraminate synthase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-N-acetylneuraminate synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-N-acetylneuraminic acid synthase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-NANA synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-Neu5Ac synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-NeuAc synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-NeuNAc synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-sialate diphosphorylase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-sialate pyrophosphorylase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-sialate synthase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-sialate synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-sialic acid synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CMP-sialic synthetase activity" EXACT [EC:2.7.7.43]
synonym: "CTP:N-acylneuraminate cytidylyltransferase activity" EXACT []
synonym: "cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43]
synonym: "cytidine 5'-monophosphosialic acid synthetase activity" EXACT [EC:2.7.7.43]
synonym: "cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43]
synonym: "cytidine monophosphoacetylneuraminic synthetase activity" EXACT [EC:2.7.7.43]
synonym: "cytidine monophosphosialate pyrophosphorylase activity" EXACT [EC:2.7.7.43]
synonym: "cytidine monophosphosialate synthetase activity" EXACT [EC:2.7.7.43]
synonym: "cytidine monophosphosialic acid synthetase activity" EXACT [EC:2.7.7.43]
xref: EC:2.7.7.43
xref: MetaCyc:ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0008782
name: adenosylhomocysteine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine." [EC:3.2.2.9]
subset: gosubset_prok
synonym: "5'-methyladenosine nucleosidase activity" EXACT [EC:3.2.2.9]
synonym: "AdoHcy/MTA nucleosidase activity" EXACT [EC:3.2.2.9]
synonym: "S-adenosyl-L-homocysteine homocysteinylribohydrolase activity" EXACT [EC:3.2.2.9]
synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.2.2.9]
synonym: "S-adenosylhomocysteine nucleosidase activity" EXACT [EC:3.2.2.9]
synonym: "S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.9]
xref: EC:3.2.2.9
xref: MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0008783
name: agmatinase activity
namespace: molecular_function
def: "Catalysis of the reaction: agmatine + H2O = putrescine + urea." [EC:3.5.3.11]
subset: gosubset_prok
synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.11]
synonym: "agmatine ureohydrolase activity" EXACT [EC:3.5.3.11]
synonym: "SpeB" RELATED [EC:3.5.3.11]
xref: EC:3.5.3.11
xref: MetaCyc:AGMATIN-RXN
xref: Reactome:26116 "agmatinase activity"
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0008784
name: alanine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine = D-alanine." [EC:5.1.1.1]
subset: gosubset_prok
synonym: "L-alanine racemase activity" EXACT [EC:5.1.1.1]
xref: EC:5.1.1.1
xref: MetaCyc:ALARACECAT-RXN
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0008785
name: alkyl hydroperoxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol." [UM-BBD_enzymeID:e0429]
subset: gosubset_prok
xref: EC:1.8.1.-
xref: UM-BBD_enzymeID:e0429
is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008786
name: allose 6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate." [MetaCyc:RXN0-303]
xref: EC:5.3.1.-
xref: MetaCyc:RXN0-303
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008787
name: allose kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate." [EC:2.7.1.55]
subset: gosubset_prok
synonym: "allokinase (phosphorylating)" EXACT [EC:2.7.1.55]
synonym: "allokinase activity" EXACT [EC:2.7.1.55]
synonym: "ATP:D-allose 6-phosphotransferase activity" EXACT [EC:2.7.1.55]
synonym: "D-allokinase activity" EXACT [EC:2.7.1.55]
synonym: "D-allose-6-kinase activity" EXACT [EC:2.7.1.55]
xref: EC:2.7.1.55
xref: MetaCyc:ALLOSE-KINASE-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008788
name: alpha,alpha-phosphotrehalase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.93]
subset: gosubset_prok
synonym: "alpha,alpha-trehalose-6-phosphate phosphoglucohydrolase activity" EXACT [EC:3.2.1.93]
synonym: "phosphotrehalase activity" EXACT [EC:3.2.1.93]
synonym: "trehalose-6-phosphate hydrolase activity" EXACT [EC:3.2.1.93]
xref: EC:3.2.1.93
xref: MetaCyc:TRE6PHYDRO-RXN
is_a: GO:0015927 ! trehalase activity

[Term]
id: GO:0008789
name: altronate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O." [EC:4.2.1.7]
subset: gosubset_prok
synonym: "D-altronate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" EXACT [EC:4.2.1.7]
synonym: "D-altronate hydro-lyase activity" EXACT [EC:4.2.1.7]
xref: EC:4.2.1.7
xref: MetaCyc:ALTRODEHYDRAT-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008790
name: arabinose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose = D-ribulose." [EC:5.3.1.3]
synonym: "D-arabinose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.3]
synonym: "D-arabinose isomerase activity" NARROW [EC:5.3.1.3]
synonym: "D-arabinose ketol-isomerase activity" EXACT [EC:5.3.1.3]
synonym: "D-arabinose(L-fucose) isomerase activity" EXACT [EC:5.3.1.3]
xref: EC:5.3.1.3
xref: MetaCyc:DARABISOM-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008791
name: arginine N-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine." [EC:2.3.1.109]
subset: gosubset_prok
synonym: "AOST activity" EXACT [EC:2.3.1.109]
synonym: "arginine and ornithine N(2)-succinyltransferase activity" EXACT [EC:2.3.1.109]
synonym: "arginine and ornithine N2-succinyltransferase activity" EXACT [EC:2.3.1.109]
synonym: "arginine succinyltransferase activity" EXACT [EC:2.3.1.109]
synonym: "AST activity" EXACT [EC:2.3.1.109]
synonym: "AstA" RELATED [EC:2.3.1.109]
synonym: "succinyl-CoA:L-arginine 2-N-succinyltransferase activity" EXACT [EC:2.3.1.109]
synonym: "succinyl-CoA:L-arginine N2-succinyltransferase activity" EXACT [EC:2.3.1.109]
xref: EC:2.3.1.109
xref: MetaCyc:ARGININE-N-SUCCINYLTRANSFERASE-RXN
is_a: GO:0016749 ! N-succinyltransferase activity

[Term]
id: GO:0008792
name: arginine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine = agmatine + CO2." [EC:4.1.1.19]
subset: gosubset_prok
synonym: "L-arginine carboxy-lyase (agmatine-forming)" EXACT [EC:4.1.1.19]
synonym: "L-arginine carboxy-lyase activity" EXACT [EC:4.1.1.19]
synonym: "SpeA" RELATED [EC:4.1.1.19]
xref: EC:4.1.1.19
xref: MetaCyc:ARGDECARBOX-RXN
xref: Reactome:26125 "arginine decarboxylase activity"
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008793
name: aromatic-amino-acid:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate." [EC:2.6.1.57]
subset: gosubset_prok
synonym: "ArAT" RELATED [EC:2.6.1.57]
synonym: "aromatic amino acid aminotransferase activity" EXACT [EC:2.6.1.57]
synonym: "aromatic amino acid transferase activity" EXACT []
synonym: "aromatic aminotransferase activity" EXACT []
synonym: "aromatic-amino-acid transaminase activity" EXACT [EC:2.6.1.57]
xref: EC:2.6.1.57
xref: MetaCyc:2.6.1.57-RXN
xref: UM-BBD_enzymeID:e0142
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0008794
name: arsenate reductase (glutaredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione." [EC:1.20.4.1, GOC:kd, PMID:10593884]
subset: gosubset_prok
synonym: "glutharedoxin:arsenate oxidoreductase activity" EXACT [EC:1.20.4.1]
xref: EC:1.20.4.1
xref: MetaCyc:RXN-982
xref: UM-BBD_enzymeID:e0261
is_a: GO:0030611 ! arsenate reductase activity
is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulfide as acceptor

[Term]
id: GO:0008795
name: NAD+ synthase activity
namespace: molecular_function
alt_id: GO:0008749
alt_id: GO:0016965
def: "Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+." [EC:6.3.1.5]
subset: gosubset_prok
synonym: "deamido-NAD+:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.5]
synonym: "diphosphopyridine nucleotide synthetase activity" EXACT [EC:6.3.1.5]
synonym: "NAD synthase (AMP-forming)" EXACT []
synonym: "NAD synthase activity" EXACT []
synonym: "NAD synthetase activity" EXACT [EC:6.3.1.5]
synonym: "NAD(+) synthetase activity" EXACT [EC:6.3.1.5]
synonym: "NAD+ synthetase activity" EXACT [EC:6.3.1.5]
synonym: "nicotinamide adenine dinucleotide synthetase activity" EXACT [EC:6.3.1.5]
xref: EC:6.3.1.5
xref: MetaCyc:NAD-SYNTH-NH3-RXN
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0008796
name: bis(5'-nucleosyl)-tetraphosphatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides." [GOC:ai]
subset: gosubset_prok
xref: EC:3.6.1.-
is_a: GO:0004551 ! nucleotide diphosphatase activity

[Term]
id: GO:0008797
name: aspartate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate = fumarate + NH3." [EC:4.3.1.1]
subset: gosubset_prok
synonym: "aspartase activity" EXACT [EC:4.3.1.1]
synonym: "fumaric aminase activity" EXACT [EC:4.3.1.1]
synonym: "L-aspartase activity" EXACT [EC:4.3.1.1]
synonym: "L-aspartate ammonia-lyase (fumarate-forming)" EXACT [EC:4.3.1.1]
synonym: "L-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.1]
xref: EC:4.3.1.1
xref: MetaCyc:ASPARTASE-RXN
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0008798
name: beta-aspartyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide." [EC:3.4.19.5]
subset: gosubset_prok
synonym: "beta-aspartyl dipeptidase activity" EXACT [EC:3.4.19.5]
synonym: "beta-aspartyl peptidase activity" EXACT [EC:3.4.19.5]
xref: EC:3.4.19.5
xref: MetaCyc:3.4.19.5-RXN
is_a: GO:0008242 ! omega peptidase activity

[Term]
id: GO:0008800
name: beta-lactamase activity
namespace: molecular_function
def: "Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid." [EC:3.5.2.6]
subset: gosubset_prok
synonym: "ampicillinase activity" EXACT [EC:3.5.2.6]
synonym: "beta-lactam hydrolase activity" EXACT [EC:3.5.2.6]
synonym: "beta-lactamase A, B, C" RELATED [EC:3.5.2.6]
synonym: "beta-lactamase AME I" RELATED [EC:3.5.2.6]
synonym: "beta-lactamase I-III" RELATED [EC:3.5.2.6]
synonym: "cephalosporin-beta-lactamase activity" EXACT [EC:3.5.2.6]
synonym: "exopenicillinase activity" EXACT [EC:3.5.2.6]
synonym: "neutrapen" RELATED [EC:3.5.2.6]
synonym: "penicillin amido-beta-lactamhydrolase activity" EXACT [EC:3.5.2.6]
synonym: "penicillin beta-lactamase activity" EXACT [EC:3.5.2.6]
synonym: "penicillinase I, II" RELATED [EC:3.5.2.6]
xref: EC:3.5.2.6
xref: MetaCyc:BETA-LACTAMASE-RXN
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0008801
name: beta-phosphoglucomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate." [EC:5.4.2.6]
subset: gosubset_prok
synonym: "beta-D-glucose 1,6-phosphomutase activity" EXACT [EC:5.4.2.6]
xref: EC:5.4.2.6
xref: MetaCyc:BETA-PHOSPHOGLUCOMUTASE-RXN
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0008802
name: betaine-aldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+." [EC:1.2.1.8]
subset: gosubset_prok
synonym: "BADH activity" EXACT [EC:1.2.1.8]
synonym: "betaine aldehyde dehydrogenase activity" EXACT [EC:1.2.1.8]
synonym: "betaine aldehyde oxidase activity" EXACT [EC:1.2.1.8]
synonym: "betaine-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.8]
synonym: "BetB" RELATED [EC:1.2.1.8]
xref: EC:1.2.1.8
xref: MetaCyc:BADH-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008803
name: bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
namespace: molecular_function
def: "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = 2 NDP." [EC:3.6.1.41, PMID:6317672]
subset: gosubset_prok
synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" EXACT [EC:3.6.1.41]
synonym: "adenosine tetraphosphate phosphodiesterase activity" EXACT [EC:3.6.1.41]
synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.41]
synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.41]
synonym: "bis(5'-adenosyl) tetraphosphatase activity" EXACT [EC:3.6.1.41]
synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase activity" EXACT [EC:3.6.1.41]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.41]
synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity" EXACT [EC:3.6.1.41]
synonym: "diadenosine polyphosphate hydrolase activity" EXACT [EC:3.6.1.41]
synonym: "diadenosine tetraphosphatase (symmetrical)" NARROW []
synonym: "diadenosine tetraphosphate hydrolase activity" EXACT [EC:3.6.1.41]
synonym: "diadenosinetetraphosphatase (symmetrical) activity" EXACT [EC:3.6.1.41]
synonym: "dinucleosidetetraphosphatase (symmetrical) activity" EXACT [EC:3.6.1.41]
synonym: "dinucleosidetetraphosphate (symmetrical)" RELATED [EC:3.6.1.41]
synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" EXACT [EC:3.6.1.41]
synonym: "symmetrical diadenosine tetraphosphate hydrolase activity" EXACT [EC:3.6.1.41]
xref: EC:3.6.1.41
xref: MetaCyc:3.6.1.41-RXN
is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity

[Term]
id: GO:0008804
name: carbamate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate." [EC:2.7.2.2]
subset: gosubset_prok
synonym: "ATP:carbamate phosphotransferase activity" EXACT [EC:2.7.2.2]
synonym: "carbamoyl phosphokinase activity" EXACT [EC:2.7.2.2]
synonym: "carbamyl phosphokinase activity" EXACT [EC:2.7.2.2]
synonym: "CKase activity" EXACT [EC:2.7.2.2]
xref: EC:2.7.2.2
xref: MetaCyc:CARBAMATE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0008805
name: carbon-monoxide oxygenase activity
namespace: molecular_function
alt_id: GO:0018999
alt_id: GO:0047767
def: "Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561." [EC:1.2.2.4]
synonym: "carbon monoxide oxidase activity" EXACT [EC:1.2.2.4]
synonym: "carbon monoxide oxygenase (cytochrome b-561) activity" NARROW [EC:1.2.2.4]
synonym: "carbon monoxide oxygenase activity" EXACT []
synonym: "carbon monoxide,water:cytochrome b-561 oxidoreductase activity" EXACT [EC:1.2.2.4]
synonym: "carbon monoxide:methylene blue oxidoreductase activity" NARROW [EC:1.2.2.4]
synonym: "carbon-monoxide dehydrogenase (cytochrome b-561)" EXACT [EC:1.2.2.4]
synonym: "cytochrome b561" NARROW []
xref: EC:1.2.2.4
xref: MetaCyc:1.2.2.4-RXN
xref: UM-BBD_enzymeID:e0180
xref: Wikipedia:Carbon-monoxide_dehydrogenase_(cytochrome_b-561)
is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor

[Term]
id: GO:0008806
name: carboxymethylenebutenolidase activity
namespace: molecular_function
alt_id: GO:0018735
def: "Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate." [EC:3.1.1.45]
subset: gosubset_prok
synonym: "4-carboxymethylenebut-2-en-4-olide lactonohydrolase activity" EXACT [EC:3.1.1.45]
synonym: "carboxymethylene butenolide hydrolase activity" EXACT [EC:3.1.1.45]
synonym: "dienelactone hydrolase activity" EXACT [EC:3.1.1.45]
synonym: "maleylacetate enol-lactonase activity" EXACT [EC:3.1.1.45]
xref: EC:3.1.1.45
xref: MetaCyc:CARBOXYMETHYLENEBUTENOLIDASE-RXN
xref: UM-BBD_enzymeID:e0066
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0008807
name: carboxyvinyl-carboxyphosphonate phosphorylmutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2." [EC:2.7.8.23]
subset: gosubset_prok
synonym: "1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)" EXACT [EC:2.7.8.23]
synonym: "carboxyphosphonoenolpyruvate phosphonomutase activity" EXACT [EC:2.7.8.23]
synonym: "CPEP phosphonomutase activity" EXACT [EC:2.7.8.23]
xref: EC:2.7.8.23
xref: MetaCyc:2.7.8.23-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0008808
name: cardiolipin synthase activity
namespace: molecular_function
def: "Phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol." [GOC:jl]
subset: gosubset_prok
synonym: "cardiolipin synthetase activity" BROAD []
synonym: "diphosphatidylglycerol synthase activity" EXACT []
xref: EC:2.7.8.-
xref: MetaCyc:CARDIOLIPSYN-RXN
is_a: GO:0030572 ! phosphatidyltransferase activity

[Term]
id: GO:0008809
name: carnitine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-carnitine = L-carnitine." [MetaCyc:CARNRACE-RXN]
xref: EC:5.1.-.-
xref: MetaCyc:CARNRACE-RXN
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0008810
name: cellulase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans." [EC:3.2.1.4]
subset: gosubset_prok
synonym: "1,4-(1,3;1,4)-beta-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.4]
synonym: "9.5 cellulase activity" EXACT [EC:3.2.1.4]
synonym: "alkali cellulase activity" EXACT [EC:3.2.1.4]
synonym: "avicelase activity" BROAD [EC:3.2.1.4]
synonym: "beta-1,4-endoglucan hydrolase activity" EXACT [EC:3.2.1.4]
synonym: "beta-1,4-glucanase activity" BROAD [EC:3.2.1.4]
synonym: "carboxymethyl cellulase activity" NARROW [EC:3.2.1.4]
synonym: "celluase A" RELATED [EC:3.2.1.4]
synonym: "celludextrinase activity" EXACT [EC:3.2.1.4]
synonym: "cellulase A 3" RELATED [EC:3.2.1.4]
synonym: "cellulosin AP" RELATED [EC:3.2.1.4]
synonym: "endo-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.4]
synonym: "endo-1,4-beta-D-glucanohydrolase activity" EXACT [EC:3.2.1.4]
synonym: "endo-1,4-beta-glucanase activity" EXACT [EC:3.2.1.4]
synonym: "endoglucanase activity" EXACT [EC:3.2.1.4]
synonym: "endoglucanase D" RELATED [EC:3.2.1.4]
synonym: "pancellase SS" RELATED [EC:3.2.1.4]
xref: EC:3.2.1.4
xref: MetaCyc:RXN-2043
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0008811
name: chloramphenicol O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + chloramphenicol = CoA + chloramphenicol 3-acetate." [EC:2.3.1.28]
subset: gosubset_prok
synonym: "acetyl-CoA:chloramphenicol 3-O-acetyltransferase activity" EXACT [EC:2.3.1.28]
synonym: "CAT I" RELATED [EC:2.3.1.28]
synonym: "CAT II" RELATED [EC:2.3.1.28]
synonym: "CAT III" RELATED [EC:2.3.1.28]
synonym: "chloramphenicol acetylase activity" EXACT [EC:2.3.1.28]
synonym: "chloramphenicol acetyltransferase activity" EXACT [EC:2.3.1.28]
synonym: "chloramphenicol transacetylase activity" EXACT [EC:2.3.1.28]
xref: EC:2.3.1.28
xref: MetaCyc:CHLORAMPHENICOL-O-ACETYLTRANSFERASE-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0008812
name: choline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: choline + acceptor = betaine aldehyde + reduced acceptor." [EC:1.1.99.1]
subset: gosubset_prok
synonym: "choline oxidase activity" BROAD [EC:1.1.99.1]
synonym: "choline-cytochrome c reductase activity" RELATED [EC:1.1.99.1]
synonym: "choline:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.1]
synonym: "choline:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.1]
synonym: "choline:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.1]
xref: EC:1.1.99.1
xref: MetaCyc:CHD-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0008813
name: chorismate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate." [EC:4.1.3.40, IMG:00552, MetaCyc:CHORPYRLY-RXN]
subset: gosubset_prok
synonym: "4-hydroxybenzoate synthetase activity" EXACT []
synonym: "chorismate pyruvate lyase activity" EXACT []
synonym: "chorismate pyruvate-lyase (4-hydroxybenzoate-forming) activity" EXACT [EC:4.1.3.40]
synonym: "CL" RELATED [EC:4.1.3.40]
synonym: "CPL" RELATED [EC:4.1.3.40]
synonym: "UbiC" RELATED [EC:4.1.3.40]
xref: EC:4.1.3.40
xref: MetaCyc:CHORPYRLY-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008814
name: citrate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA." [EC:2.8.3.10]
subset: gosubset_prok
synonym: "acetyl-CoA:citrate CoA-transferase activity" EXACT [EC:2.8.3.10]
xref: EC:2.8.3.10
xref: MetaCyc:CITTRANS-RXN
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0008815
name: citrate (pro-3S)-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: citrate = acetate + oxaloacetate." [EC:4.1.3.6]
subset: gosubset_prok
synonym: "citrase activity" EXACT [EC:4.1.3.6]
synonym: "citratase activity" EXACT [EC:4.1.3.6]
synonym: "citrate aldolase activity" EXACT [EC:4.1.3.6]
synonym: "citrate lyase activity" EXACT []
synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]" RELATED [EC:4.1.3.6]
synonym: "citrate oxaloacetate-lyase activity" EXACT [EC:4.1.3.6]
synonym: "citric aldolase activity" EXACT [EC:4.1.3.6]
synonym: "citridesmolase activity" EXACT [EC:4.1.3.6]
synonym: "citritase activity" EXACT [EC:4.1.3.6]
xref: EC:4.1.3.6
xref: MetaCyc:CITLY-RXN
xref: Reactome:26375 "citrate (pro-3S)-lyase activity"
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008816
name: citryl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate." [EC:4.1.3.34]
subset: gosubset_prok
synonym: "(3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.34]
synonym: "(3S)-citryl-CoA oxaloacetate-lyase activity" EXACT [EC:4.1.3.34]
xref: EC:4.1.3.34
xref: MetaCyc:CITRYLY-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008817
name: cob(I)yrinic acid a,c-diamide adenosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin." [EC:2.5.1.17]
subset: gosubset_prok
synonym: "aquacob(I)alamin adenosyltransferase activity" EXACT [EC:2.5.1.17]
synonym: "aquocob(I)alamin vitamin B12s adenosyltransferase activity" RELATED [EC:2.5.1.17]
synonym: "ATP:cob(I)alamin Co-beta-adenosyltransferase activity" EXACT [EC:2.5.1.17]
synonym: "ATP:cob(I)alamin cobeta-adenosyltransferase activity" EXACT [EC:2.5.1.17]
synonym: "ATP:cob(I)yrinic acid-a,c-diamide cobeta-adenosyltransferase activity" EXACT [EC:2.5.1.17]
synonym: "ATP:corrinoid adenosyltransferase activity" EXACT [EC:2.5.1.17]
synonym: "cob(I)alamin adenosyltransferase activity" EXACT []
synonym: "CobA" RELATED [EC:2.5.1.17]
synonym: "vitamin B12s adenosyltransferase activity" EXACT [EC:2.5.1.17]
xref: EC:2.5.1.17
xref: MetaCyc:COBALADENOSYLTRANS-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0008818
name: cobalamin 5'-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP." [MetaCyc:COBALAMIN5PSYN-RXN]
subset: gosubset_prok
xref: MetaCyc:COBALAMIN5PSYN-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0008819
name: cobinamide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate." [http://www.mblab.gla.ac.uk/, PMID:1655696]
subset: gosubset_prok
xref: EC:2.7.1.-
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008820
name: cobinamide phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosylcobinamide-phosphate + GTP = adenosylcobinamide-GDP + diphosphate." [MetaCyc:COBINPGUANYLYLTRANS-RXN]
subset: gosubset_prok
synonym: "GTP:cobinamide phosphate guanylyltransferase activity" EXACT []
xref: MetaCyc:COBINPGUANYLYLTRANS-RXN
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0008821
name: crossover junction endodeoxyribonuclease activity
namespace: molecular_function
alt_id: GO:0008844
def: "Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [EC:3.1.22.4]
synonym: "crossover junction endoribonuclease activity" EXACT []
synonym: "cruciform-cutting endonuclease activity" EXACT [EC:3.1.22.-]
synonym: "endo X3" RELATED [EC:3.1.22.4]
synonym: "Endo X3 activity" NARROW [EC:3.1.22.-]
synonym: "endodeoxyribonuclease RUS activity" EXACT []
synonym: "endonuclease RuvC activity" NARROW [EC:3.1.22.-]
synonym: "endonuclease VII activity" NARROW [EC:3.1.22.-]
synonym: "endonuclease X3 activity" NARROW [EC:3.1.22.-]
synonym: "Hje endonuclease activity" EXACT [EC:3.1.22.-]
synonym: "Holliday junction endonuclease CCE1 activity" NARROW [EC:3.1.22.-]
synonym: "Holliday junction nuclease activity" EXACT [EC:3.1.22.-]
synonym: "Holliday junction resolvase activity" NARROW [EC:3.1.22.-]
synonym: "Holliday junction-cleaving endonuclease activity" EXACT [EC:3.1.22.-]
synonym: "Holliday junction-resolving endoribonuclease activity" NARROW [EC:3.1.22.-]
synonym: "resolving enzyme CCE1 activity" NARROW [EC:3.1.22.-]
synonym: "RusA endonuclease activity" NARROW [EC:3.1.22.-]
synonym: "RusA holliday junction resolvase" NARROW [EC:3.1.22.4]
synonym: "RusA Holliday junction resolvase activity" NARROW [EC:3.1.22.-]
synonym: "RuvC endonuclease activity" NARROW [EC:3.1.22.-]
synonym: "SpCCe1 holliday junction resolvase" NARROW [EC:3.1.22.4]
synonym: "SpCCe1 Holliday junction resolvase activity" NARROW [EC:3.1.22.-]
xref: EC:3.1.22.-
xref: EC:3.1.22.4
xref: MetaCyc:3.1.22.4-RXN
is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0008822
name: crotonobetaine/carnitine-CoA ligase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a bifunctional gene product.
is_obsolete: true
replaced_by: GO:0051108
replaced_by: GO:0051109

[Term]
id: GO:0008823
name: cupric reductase activity
namespace: molecular_function
xref: EC:1.16.1.-
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0008824
name: cyanate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanate (NCO-) + H2O = carbamate (H2N-CO-O-)." [EC:4.2.1.104]
comment: Note that this function was formerly EC:4.3.99.1.
subset: gosubset_prok
synonym: "carbamate hydro-lyase activity" EXACT [EC:4.2.1.104]
synonym: "cyanase activity" EXACT []
synonym: "cyanate aminohydrolase activity" EXACT [EC:4.2.1.104]
synonym: "cyanate C-N-lyase activity" EXACT [EC:4.2.1.104]
synonym: "cyanate hydrolase activity" EXACT [EC:4.2.1.104]
synonym: "cyanate lyase activity" EXACT []
xref: EC:4.2.1.104
xref: MetaCyc:R524-RXN
xref: UM-BBD_enzymeID:e0396
is_a: GO:0016840 ! carbon-nitrogen lyase activity

[Term]
id: GO:0008825
name: cyclopropane-fatty-acyl-phospholipid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid." [EC:2.1.1.79]
subset: gosubset_prok
synonym: "CFA synthase activity" EXACT [EC:2.1.1.79]
synonym: "cyclopropane fatty acid synthase activity" EXACT [EC:2.1.1.79]
synonym: "cyclopropane fatty acid synthetase activity" EXACT [EC:2.1.1.79]
synonym: "cyclopropane synthase activity" EXACT [EC:2.1.1.79]
synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.79]
synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)" EXACT [EC:2.1.1.79]
synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.79]
xref: EC:2.1.1.79
xref: MetaCyc:2.1.1.79-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008826
name: cysteine sulfinate desulfinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-sulfinoalanine = L-alanine + SO3(2-)." [MetaCyc:RXN0-279]
synonym: "cysteine sulphinate desulphinase activity" EXACT []
xref: EC:4.4.1.-
xref: MetaCyc:RXN0-279
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0008827
name: cytochrome o ubiquinol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: ubiquinol + O2 = ubiquinone + 2 H2R; cytochrome O is the electron acceptor." [GOC:mah, MetaCyc:CYT-UBIQUINOL-OXID-RXN]
subset: gosubset_prok
xref: EC:1.10.3.-
is_a: GO:0015002 ! heme-copper terminal oxidase activity
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0008828
name: dATP pyrophosphohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxy-ATP + H2O = dAMP + diphosphate." [MetaCyc:RXN0-384]
subset: gosubset_prok
xref: EC:3.6.1.-
xref: MetaCyc:RXN0-384
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity

[Term]
id: GO:0008829
name: dCTP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: dCTP + H2O = dUTP + NH3." [EC:3.5.4.13]
subset: gosubset_prok
synonym: "5-methyl-dCTP deaminase activity" EXACT [EC:3.5.4.13]
synonym: "dCTP aminohydrolase activity" EXACT [EC:3.5.4.13]
synonym: "deoxycytidine triphosphate deaminase activity" EXACT [EC:3.5.4.13]
xref: EC:3.5.4.13
xref: MetaCyc:DCTP-DEAM-RXN
xref: Reactome:26405 "dCTP deaminase activity"
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0008830
name: dTDP-4-dehydrorhamnose 3,5-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose." [EC:5.1.3.13]
subset: gosubset_prok
synonym: "dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase activity" EXACT [EC:5.1.3.13]
synonym: "dTDP-4-keto-6-deoxyglucose 3,5-epimerase activity" EXACT [EC:5.1.3.13]
synonym: "dTDP-L-rhamnose synthetase activity" EXACT [EC:5.1.3.13]
synonym: "TDP-4-keto-L-rhamnose-3,5-epimerase activity" EXACT [EC:5.1.3.13]
synonym: "TDP-4-ketorhamnose 3,5-epimerase activity" EXACT [EC:5.1.3.13]
synonym: "thymidine diphospho-4-ketorhamnose 3,5-epimerase activity" RELATED [EC:5.1.3.13]
xref: EC:5.1.3.13
xref: MetaCyc:DTDPDEHYDRHAMEPIM-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0008831
name: dTDP-4-dehydrorhamnose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+." [EC:1.1.1.133]
subset: gosubset_prok
synonym: "dTDP-4-keto-L-rhamnose reductase activity" EXACT [EC:1.1.1.133]
synonym: "dTDP-4-ketorhamnose reductase activity" EXACT [EC:1.1.1.133]
synonym: "dTDP-6-deoxy-L-mannose dehydrogenase activity" EXACT [EC:1.1.1.133]
synonym: "dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.133]
synonym: "reductase, thymidine diphospho-4-ketorhamnose" EXACT [EC:1.1.1.133]
synonym: "TDP-4-keto-rhamnose reductase activity" EXACT [EC:1.1.1.133]
synonym: "thymidine diphospho-4-ketorhamnose reductase activity" EXACT [EC:1.1.1.133]
xref: EC:1.1.1.133
xref: MetaCyc:DTDPDEHYRHAMREDUCT-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008832
name: dGTPase activity
namespace: molecular_function
def: "Catalysis of the reaction: dGTP + H2O = deoxyguanosine + triphosphate." [EC:3.1.5.1]
subset: gosubset_prok
synonym: "deoxy-GTPase activity" EXACT [EC:3.1.5.1]
synonym: "deoxyguanosine 5-triphosphate triphosphohydrolase activity" EXACT [EC:3.1.5.1]
synonym: "deoxyguanosine triphosphatase activity" EXACT [EC:3.1.5.1]
synonym: "deoxyguanosine triphosphate triphosphohydrolase activity" EXACT [EC:3.1.5.1]
synonym: "deoxyguanosinetriphosphate triphosphohydrolase activity" EXACT []
synonym: "dGTP triphosphohydrolase activity" EXACT [EC:3.1.5.1]
xref: EC:3.1.5.1
xref: MetaCyc:DGTPTRIPHYDRO-RXN
is_a: GO:0016793 ! triphosphoric monoester hydrolase activity

[Term]
id: GO:0008833
name: deoxyribonuclease IV (phage-T4-induced) activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products." [EC:3.1.21.2]
subset: gosubset_prok
synonym: "deoxriboendonuclease activity" EXACT [EC:3.1.21.2]
synonym: "deoxyribonuclease IV (phage T4-induced) activity" EXACT [EC:3.1.21.2]
synonym: "DNA-adenine-transferase activity" EXACT [EC:3.1.21.2]
synonym: "E. coli endonuclease IV" RELATED [EC:3.1.21.2]
synonym: "endodeoxyribonuclease IV (phage T(4)-induced) activity" EXACT [EC:3.1.21.2]
synonym: "endodeoxyribonuclease IV (phage T4-induced) activity" EXACT [EC:3.1.21.2]
synonym: "endonuclease II" RELATED [EC:3.1.21.2]
synonym: "endonuclease IV activity" RELATED [EC:3.1.21.2]
synonym: "Escherichia coli endonuclease II" RELATED [EC:3.1.21.2]
synonym: "redoxyendonuclease activity" EXACT [EC:3.1.21.2]
xref: EC:3.1.21.2
xref: MetaCyc:3.1.21.2-RXN
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008834
name: di-trans,poly-cis-decaprenylcistransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate." [EC:2.5.1.31]
subset: gosubset_prok
synonym: "bactoprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31]
synonym: "di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity" EXACT [EC:2.5.1.31]
synonym: "di-trans,poly-cis-undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31]
synonym: "undecaprenyl diphosphate synthase activity" EXACT []
synonym: "undecaprenyl diphosphate synthetase activity" EXACT [EC:2.5.1.31]
synonym: "undecaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.31]
synonym: "undecaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.31]
synonym: "undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31]
synonym: "UPP synthetase activity" EXACT [EC:2.5.1.31]
xref: EC:2.5.1.31
xref: MetaCyc:RXN-8999
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0008835
name: diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
namespace: molecular_function
alt_id: GO:0008485
def: "Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2O = 5-amino-6-(5-phosphoribosylamino)uracil + NH3." [EC:3.5.4.26]
subset: gosubset_prok
synonym: "2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate deaminase activity" EXACT []
synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine 2-aminohydrolase activity" EXACT [EC:3.5.4.26]
synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase activity" EXACT [EC:3.5.4.26]
xref: EC:3.5.4.26
xref: MetaCyc:RIBOFLAVINSYNDEAM-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0008836
name: diaminopimelate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2." [EC:4.1.1.20]
subset: gosubset_prok
synonym: "DAP decarboxylase activity" EXACT [EC:4.1.1.20]
synonym: "DAP-decarboxylase activity" EXACT [EC:4.1.1.20]
synonym: "diaminopimelic acid decarboxylase activity" EXACT [EC:4.1.1.20]
synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)" EXACT [EC:4.1.1.20]
synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase activity" EXACT [EC:4.1.1.20]
synonym: "meso-diaminopimelate decarboxylase activity" EXACT [EC:4.1.1.20]
xref: EC:4.1.1.20
xref: MetaCyc:DIAMINOPIMDECARB-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008837
name: diaminopimelate epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate." [EC:5.1.1.7]
subset: gosubset_prok
synonym: "LL-2,6-diaminoheptanedioate 2-epimerase activity" EXACT [EC:5.1.1.7]
xref: EC:5.1.1.7
xref: MetaCyc:DIAMINOPIMEPIM-RXN
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0008838
name: diaminopropionate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3." [EC:4.3.1.15]
subset: gosubset_prok
synonym: "2,3-diaminopropionate ammonia-lyase (adding H2O; pyruvate-forming)" EXACT [EC:4.3.1.15]
synonym: "2,3-diaminopropionate ammonia-lyase activity" EXACT [EC:4.3.1.15]
synonym: "alpha,beta-diaminopropionate ammonia-lyase activity" EXACT [EC:4.3.1.15]
synonym: "diaminopropionatase activity" EXACT [EC:4.3.1.15]
xref: EC:4.3.1.15
xref: MetaCyc:4.3.1.15-RXN
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0008839
name: dihydrodipicolinate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+." [EC:1.3.1.26]
subset: gosubset_prok
synonym: "2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.26]
synonym: "dihydrodipicolinic acid reductase activity" EXACT [EC:1.3.1.26]
xref: EC:1.3.1.26
xref: MetaCyc:DIHYDROPICRED-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008840
name: dihydrodipicolinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate-4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O." [EC:4.2.1.52]
subset: gosubset_prok
synonym: "DHDPS activity" EXACT [EC:4.2.1.52]
synonym: "dihydrodipicolinate synthetase activity" EXACT [EC:4.2.1.52]
synonym: "dihydrodipicolinic acid synthase activity" EXACT [EC:4.2.1.52]
synonym: "dihydropicolinate synthetase activity" EXACT [EC:4.2.1.52]
synonym: "L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing)" EXACT [EC:4.2.1.52]
synonym: "L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (S)-2,3-dihydropyridine-2,6-dicarboxylate-forming]" RELATED [EC:4.2.1.52]
xref: EC:4.2.1.52
xref: MetaCyc:DIHYDRODIPICSYN-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008841
name: dihydrofolate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate." [EC:6.3.2.12]
subset: gosubset_prok
synonym: "7,8-dihydrofolate synthetase activity" EXACT [EC:6.3.2.12]
synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP) activity" EXACT [EC:6.3.2.12]
synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP-forming)" EXACT [EC:6.3.2.12]
synonym: "DHFS activity" EXACT [EC:6.3.2.12]
synonym: "dihydrofolate synthetase activity" EXACT [EC:6.3.2.12]
synonym: "dihydrofolate synthetase-folylpolyglutamate synthetase activity" EXACT [EC:6.3.2.12]
synonym: "dihydropteroate:L-glutamate ligase (ADP-forming) activity" EXACT [EC:6.3.2.12]
synonym: "FHFS activity" EXACT [EC:6.3.2.12]
synonym: "FHFS/FPGS activity" EXACT [EC:6.3.2.12]
synonym: "folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity" EXACT [EC:6.3.2.12]
synonym: "H(2)-folate synthetase activity" EXACT [EC:6.3.2.12]
synonym: "H2-folate synthetase activity" EXACT [EC:6.3.2.12]
xref: EC:6.3.2.12
xref: MetaCyc:DIHYDROFOLATESYNTH-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0008842
name: diphosphate-purine nucleoside kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide." [EC:2.7.1.143]
synonym: "diphosphate-dependent nucleoside kinase activity" EXACT [EC:2.7.1.143]
synonym: "diphosphate:purine nucleoside phosphotransferase activity" EXACT [EC:2.7.1.143]
synonym: "pyrophosphate-dependent nucleoside kinase activity" EXACT [EC:2.7.1.143]
synonym: "pyrophosphate-purine nucleoside kinase activity" EXACT [EC:2.7.1.143]
xref: EC:2.7.1.143
xref: MetaCyc:2.7.1.143-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019206 ! nucleoside kinase activity

[Term]
id: GO:0008843
name: endochitinase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of nonterminal 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin and chitodextrins." [EC:3.2.1.14]
is_a: GO:0004568 ! chitinase activity

[Term]
id: GO:0008845
name: endonuclease VIII activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [PMID:12713806]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0000703
consider: GO:0003684
consider: GO:0003906
consider: GO:0004519
consider: GO:0008081
consider: GO:0019104

[Term]
id: GO:0008846
name: endopeptidase La activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP." [EC:3.4.21.53]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "ATP-dependent lon proteinase" NARROW [EC:3.4.21.53]
synonym: "ATP-dependent protease La activity" EXACT [EC:3.4.21.53]
synonym: "ATP-dependent serine proteinase activity" RELATED [EC:3.4.21.53]
synonym: "Escherichia coli proteinase La" RELATED [EC:3.4.21.53]
synonym: "Escherichia coli serine proteinase La" RELATED [EC:3.4.21.53]
synonym: "gene lon protease activity" EXACT [EC:3.4.21.53]
synonym: "gene lon proteins" RELATED [EC:3.4.21.53]
synonym: "lon proteinase" NARROW [EC:3.4.21.53]
synonym: "PIM1 protease activity" EXACT [EC:3.4.21.53]
synonym: "PIM1 proteinase activity" EXACT [EC:3.4.21.53]
synonym: "protease La" RELATED [EC:3.4.21.53]
synonym: "proteinase La" RELATED [EC:3.4.21.53]
synonym: "serine protease La" RELATED [EC:3.4.21.53]
xref: EC:3.4.21.53
xref: MetaCyc:3.4.21.53-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008847
name: Enterobacter ribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.6]
subset: gosubset_prok
synonym: "enterobacter ribonuclease activity" EXACT [EC:3.1.27.6]
synonym: "Enterobacter RNase activity" EXACT []
xref: EC:3.1.27.6
xref: MetaCyc:3.1.27.6-RXN
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0008848
name: enterobactin synthetase
namespace: molecular_function
alt_id: GO:0008850
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a process rather than a function.
synonym: "enterochelin synthetase activity" EXACT []
synonym: "nonribosomal peptide synthetase" RELATED []
is_obsolete: true
replaced_by: GO:0009239

[Term]
id: GO:0008849
name: enterochelin esterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the enterochelin moiety of ferric-enterochelin to yield ultimately three molecules of N-2,3-dihydroxybenzoylserine." [PMID:4565531]
synonym: "enterobactin esterase activity" EXACT []
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0008851
name: ethanolamine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethanolamine = acetaldehyde + NH3." [EC:4.3.1.7]
subset: gosubset_prok
synonym: "ethanolamine ammonia-lyase (acetaldehyde-forming) activity" EXACT [EC:4.3.1.7]
synonym: "ethanolamine deaminase activity" EXACT [EC:4.3.1.7]
xref: EC:4.3.1.7
xref: MetaCyc:ETHAMLY-RXN
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0008852
name: exodeoxyribonuclease I activity
namespace: molecular_function
def: "Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.1]
subset: gosubset_prok
synonym: "E. coli exonuclease I" RELATED [EC:3.1.11.1]
synonym: "E. coli exonuclease I activity" NARROW [EC:3.1.11.1]
synonym: "Escherichia coli exonuclease I" RELATED [EC:3.1.11.1]
synonym: "exonuclease I activity" RELATED [EC:3.1.11.1]
xref: EC:3.1.11.1
xref: MetaCyc:3.1.11.1-RXN
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008853
name: exodeoxyribonuclease III activity
namespace: molecular_function
def: "Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.2]
subset: gosubset_prok
synonym: "E. coli exonuclease III" RELATED [EC:3.1.11.2]
synonym: "E. coli exonuclease III activity" NARROW [EC:3.1.11.2]
synonym: "endoribonuclease III" RELATED [EC:3.1.11.2]
synonym: "Escherichia coli exonuclease III" RELATED [EC:3.1.11.2]
synonym: "exonuclease III activity" EXACT [EC:3.1.11.2]
xref: EC:3.1.11.2
xref: MetaCyc:3.1.11.2-RXN
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008854
name: exodeoxyribonuclease V activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides." [EC:3.1.11.5]
subset: gosubset_prok
synonym: "E. coli exonuclease V" RELATED [EC:3.1.11.5]
synonym: "E. coli exonuclease V activity" NARROW [EC:3.1.11.5]
synonym: "Escherichia coli exonuclease V" RELATED [EC:3.1.11.5]
synonym: "exonuclease V activity" EXACT [EC:3.1.11.5]
synonym: "gene recBC DNase activity" EXACT [EC:3.1.11.5]
synonym: "gene recBC endoenzyme" RELATED [EC:3.1.11.5]
synonym: "gene recBCD enzymes" RELATED [EC:3.1.11.5]
synonym: "RecBC deoxyribonuclease activity" EXACT [EC:3.1.11.5]
xref: EC:3.1.11.5
xref: MetaCyc:3.1.11.5-RXN
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008855
name: exodeoxyribonuclease VII activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides." [EC:3.1.11.6]
subset: gosubset_prok
synonym: "E. coli exonuclease VII" RELATED [EC:3.1.11.6]
synonym: "E. coli exonuclease VII activity" NARROW [EC:3.1.11.6]
synonym: "endodeoxyribonuclease VII" RELATED [EC:3.1.11.6]
synonym: "Escherichia coli exonuclease VII" RELATED [EC:3.1.11.6]
synonym: "exonuclease VII activity" EXACT [EC:3.1.11.6]
xref: EC:3.1.11.6
xref: MetaCyc:3.1.11.6-RXN
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008856
name: exodeoxyribonuclease X activity
namespace: molecular_function
def: "Catalysis of the reaction: Endonucleolytic cleavage of supercoiled plasma DNA to linear DNA duplexes." [EC:3.1.22.5]
synonym: "deoxyribonuclease X activity" EXACT [EC:3.1.22.5]
synonym: "Escherichia coli endodeoxyribonuclease activity" RELATED [EC:3.1.22.5]
synonym: "Escherichia coli endodeoxyribonuclease X activity" NARROW [EC:3.1.22.5]
xref: EC:3.1.11.-
xref: MetaCyc:3.1.22.5-RXN
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008857
name: exonuclease IX activity
namespace: molecular_function
subset: gosubset_prok
is_a: GO:0004527 ! exonuclease activity

[Term]
id: GO:0008858
name: exonuclease VIII activity
namespace: molecular_function
xref: EC:3.1.11.-
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008859
name: exoribonuclease II activity
namespace: molecular_function
def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684]
subset: gosubset_prok
synonym: "5'-exoribonuclease activity" EXACT [EC:3.1.13.1]
synonym: "BN ribonuclease activity" EXACT [EC:3.1.13.1]
synonym: "Escherichia coli exo-RNase II" RELATED [EC:3.1.13.1]
synonym: "ribonuclease II activity" EXACT [EC:3.1.13.1]
synonym: "ribonuclease Q" RELATED [EC:3.1.13.1]
synonym: "RNase II" RELATED [EC:3.1.13.1]
synonym: "RNase II activity" EXACT []
xref: EC:3.1.13.1
xref: MetaCyc:3.1.13.1-RXN
is_a: GO:0008408 ! 3'-5' exonuclease activity
is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0008860
name: ferredoxin-NAD+ reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+." [EC:1.18.1.3]
subset: gosubset_prok
synonym: "ferredoxin-linked NAD reductase activity" EXACT [EC:1.18.1.3]
synonym: "ferredoxin-NAD reductase activity" EXACT []
synonym: "ferredoxin-nicotinamide adenine dinucleotide reductase activity" EXACT [EC:1.18.1.3]
synonym: "ferredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.3]
synonym: "NAD-ferredoxin reductase activity" EXACT [EC:1.18.1.3]
synonym: "NADH flavodoxin oxidoreductase activity" EXACT [EC:1.18.1.3]
synonym: "NADH-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3]
synonym: "NADH-ferredoxin reductase activity" EXACT [EC:1.18.1.3]
synonym: "NADH-ferredoxinNAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)" EXACT [EC:1.18.1.3]
synonym: "NADH-ferredoxinTOL reductase (component of toluene dioxygenase)" EXACT [EC:1.18.1.3]
synonym: "NADH2-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3]
synonym: "reductase, reduced nicotinamide adenine dinucleotide-ferredoxin" EXACT [EC:1.18.1.3]
xref: EC:1.18.1.3
xref: MetaCyc:FERREDOXIN--NAD+-REDUCTASE-RXN
is_a: GO:0008937 ! ferredoxin reductase activity

[Term]
id: GO:0008861
name: formate C-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate." [EC:2.3.1.54]
subset: gosubset_prok
synonym: "acetyl-CoA:formate C-acetyltransferase activity" EXACT [EC:2.3.1.54]
synonym: "formate acetyltransferase activity" EXACT [EC:2.3.1.54]
synonym: "pyruvate formate-lyase activity" EXACT [EC:2.3.1.54]
synonym: "pyruvic formate-lyase activity" EXACT [EC:2.3.1.54]
xref: EC:2.3.1.54
xref: MetaCyc:PYRUVFORMLY-RXN
is_a: GO:0016453 ! C-acetyltransferase activity

[Term]
id: GO:0008863
name: formate dehydrogenase activity
namespace: molecular_function
alt_id: GO:0018476
def: "Catalysis of the reaction: formate + NAD+ = CO2 + NADH + H+." [EC:1.2.1.2]
subset: gosubset_prok
synonym: "FDH I" RELATED [EC:1.2.1.2]
synonym: "FDH II" RELATED [EC:1.2.1.2]
synonym: "formate benzyl-viologen oxidoreductase" EXACT [EC:1.2.1.2]
synonym: "formate dehydrogenase (NAD)" EXACT [EC:1.2.1.2]
synonym: "formate hydrogenlyase" EXACT [EC:1.2.1.2]
synonym: "formate-NAD oxidoreductase" EXACT [EC:1.2.1.2]
synonym: "formate:NAD+ oxidoreductase" EXACT [EC:1.2.1.2]
synonym: "formic acid dehydrogenase" EXACT [EC:1.2.1.2]
synonym: "formic hydrogen-lyase" EXACT [EC:1.2.1.2]
synonym: "N-FDH" RELATED [EC:1.2.1.2]
synonym: "NAD-dependent formate dehydrogenase" EXACT [EC:1.2.1.2]
synonym: "NAD-formate dehydrogenase" EXACT [EC:1.2.1.2]
synonym: "NAD-linked formate dehydrogenase" EXACT [EC:1.2.1.2]
xref: EC:1.2.1.2
xref: MetaCyc:FORMATEDEHYDROG-RXN
xref: UM-BBD_enzymeID:e0080
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008864
name: formyltetrahydrofolate deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate." [EC:3.5.1.10]
subset: gosubset_prok
synonym: "10-formyltetrahydrofolate amidohydrolase activity" EXACT [EC:3.5.1.10]
synonym: "formyl-FH(4) hydrolase activity" EXACT [EC:3.5.1.10]
synonym: "formyltetrahydrofolate hydrolase activity" EXACT [EC:3.5.1.10]
xref: EC:3.5.1.10
xref: MetaCyc:FORMYLTHFDEFORMYL-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008865
name: fructokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate." [EC:2.7.1.4]
subset: gosubset_prok
synonym: "ATP:D-fructose 6-phosphotransferase activity" EXACT [EC:2.7.1.4]
synonym: "D-fructokinase activity" EXACT [EC:2.7.1.4]
synonym: "D-fructose(D-mannose)kinase activity" EXACT [EC:2.7.1.4]
synonym: "fructokinase (phosphorylating)" EXACT [EC:2.7.1.4]
xref: EC:2.7.1.4
xref: MetaCyc:FRUCTOKINASE-RXN
is_a: GO:0004396 ! hexokinase activity

[Term]
id: GO:0008866
name: fructuronate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannonate + NAD+ = D-fructuronate + NADH + H+." [EC:1.1.1.57]
subset: gosubset_prok
synonym: "D-mannonate dehydrogenase activity" EXACT [EC:1.1.1.57]
synonym: "D-mannonate oxidoreductase activity" EXACT [EC:1.1.1.57]
synonym: "D-mannonate:NAD oxidoreductase activity" EXACT [EC:1.1.1.57]
synonym: "D-mannonate:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.57]
synonym: "mannonate oxidoreductase activity" EXACT [EC:1.1.1.57]
synonym: "mannonic dehydrogenase activity" EXACT [EC:1.1.1.57]
xref: EC:1.1.1.57
xref: MetaCyc:MANNONOXIDOREDUCT-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008867
name: galactarate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O." [EC:4.2.1.42]
subset: gosubset_prok
synonym: "D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" EXACT [EC:4.2.1.42]
synonym: "D-galactarate hydro-lyase activity" EXACT [EC:4.2.1.42]
xref: EC:4.2.1.42
xref: MetaCyc:GALACTARDEHYDRA-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008868
name: galactitol-1-phosphate 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactitol-1-phosphate + NAD+ = L-tagatose 6-phosphate + NADH + H+." [EC:1.1.1.251]
subset: gosubset_prok
synonym: "galactitol-1-phosphate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.251]
xref: EC:1.1.1.251
xref: MetaCyc:1.1.1.251-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008869
name: galactonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O." [EC:4.2.1.6]
subset: gosubset_prok
synonym: "D-galactonate dehydrase activity" EXACT [EC:4.2.1.6]
synonym: "D-galactonate dehydratase activity" EXACT [EC:4.2.1.6]
synonym: "D-galactonate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" EXACT [EC:4.2.1.6]
synonym: "D-galactonate hydro-lyase activity" EXACT [EC:4.2.1.6]
xref: EC:4.2.1.6
xref: MetaCyc:GALACTONDEHYDRAT-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008870
name: galactoside O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside." [EC:2.3.1.18]
subset: gosubset_prok
synonym: "acetyl-CoA:beta-D-galactoside 6-acetyltransferase activity" EXACT [EC:2.3.1.18]
synonym: "galactoside acetyltransferase activity" EXACT [EC:2.3.1.18]
synonym: "thiogalactoside acetyltransferase activity" EXACT [EC:2.3.1.18]
synonym: "thiogalactoside transacetylase activity" EXACT [EC:2.3.1.18]
xref: EC:2.3.1.18
xref: MetaCyc:GALACTOACETYLTRAN-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0008871
name: aminoglycoside 2''-nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside." [EC:2.7.7.46, GOC:cb]
subset: gosubset_prok
synonym: "2''-aminoglycoside nucleotidyltransferase activity" EXACT [EC:2.7.7.46]
synonym: "gentamicin 2''- adenylyltransferase activity" NARROW [EC:2.7.7.46]
synonym: "gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46]
synonym: "gentamycin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46]
synonym: "NTP:gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46]
xref: EC:2.7.7.46
xref: MetaCyc:2.7.7.46-RXN
is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity

[Term]
id: GO:0008872
name: glucarate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O." [EC:4.2.1.40]
subset: gosubset_prok
synonym: "D-glucarate dehydratase activity" EXACT [EC:4.2.1.40]
synonym: "D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" EXACT [EC:4.2.1.40]
synonym: "D-glucarate hydro-lyase activity" EXACT [EC:4.2.1.40]
xref: EC:4.2.1.40
xref: MetaCyc:GLUCARDEHYDRA-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008873
name: gluconate 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215]
subset: gosubset_prok
synonym: "2-keto-D-gluconate reductase activity" EXACT [EC:1.1.1.215]
synonym: "2-ketogluconate reductase activity" EXACT [EC:1.1.1.215]
synonym: "D-gluconate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.215]
xref: EC:1.1.1.215
xref: MetaCyc:1.1.1.215-RXN
is_a: GO:0008875 ! gluconate dehydrogenase activity

[Term]
id: GO:0008874
name: gluconate 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.69]
subset: gosubset_prok
synonym: "5-keto-D-gluconate 5-reductase activity" EXACT [EC:1.1.1.69]
synonym: "5-keto-D-gluconate reductase" EXACT [EC:1.1.1.69]
synonym: "5-ketogluconate 5-reductase activity" EXACT [EC:1.1.1.69]
synonym: "5-ketogluconate reductase activity" EXACT [EC:1.1.1.69]
synonym: "D-gluconate:NAD(P)+ 5-oxidoreductase" EXACT [EC:1.1.1.69]
xref: EC:1.1.1.69
xref: MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN
is_a: GO:0008875 ! gluconate dehydrogenase activity

[Term]
id: GO:0008875
name: gluconate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215, EC:1.1.1.69]
subset: gosubset_prok
xref: EC:1.1.1.-
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008876
name: quinoprotein glucose dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol." [EC:1.1.5.2]
comment: Note that this was EC:1.1.99.17.
subset: gosubset_prok
synonym: "D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase activity" EXACT [EC:1.1.5.2]
synonym: "D-glucose:ubiquinone oxidoreductase activity" EXACT [EC:1.1.5.2]
synonym: "glucose dehydrogenase (PQQ-dependent) activity" EXACT [EC:1.1.5.2]
synonym: "glucose dehydrogenase (pyrroloquinoline-quinone) activity" EXACT []
synonym: "quinoprotein D-glucose dehydrogenase activity" EXACT [EC:1.1.5.2]
xref: EC:1.1.5.2
xref: MetaCyc:GLUCDEHYDROG-RXN
is_a: GO:0004344 ! glucose dehydrogenase activity
is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0008877
name: glucose-1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose 1-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.10]
subset: gosubset_prok
synonym: "alpha-D-glucose-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.10]
synonym: "D-glucose-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.10]
xref: EC:3.1.3.10
xref: MetaCyc:GLUCOSE-1-PHOSPHAT-RXN
is_a: GO:0019203 ! carbohydrate phosphatase activity

[Term]
id: GO:0008878
name: glucose-1-phosphate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose." [EC:2.7.7.27]
subset: gosubset_prok
synonym: "adenosine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27]
synonym: "adenosine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.27]
synonym: "ADGase activity" EXACT []
synonym: "ADP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27]
synonym: "ADP-glucose diphosphorylase activity" EXACT [EC:2.7.7.27]
synonym: "ADP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27]
synonym: "ADP-glucose synthase activity" EXACT [EC:2.7.7.27]
synonym: "ADP-glucose synthetase activity" EXACT [EC:2.7.7.27]
synonym: "ADP:alpha-D-glucose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27]
synonym: "ADPG pyrophosphorylase activity" EXACT []
synonym: "ATP:alpha-D-glucose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27]
synonym: "ATP:alpha-glucose-1-phosphate adenylyl transferase activity" EXACT []
synonym: "glucose 1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27]
xref: EC:2.7.7.27
xref: MetaCyc:GLUC1PADENYLTRANS-RXN
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0008879
name: glucose-1-phosphate thymidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-glucose." [EC:2.7.7.24]
subset: gosubset_prok
synonym: "dTDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.24]
synonym: "dTDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24]
synonym: "dTDP-glucose synthase activity" EXACT [EC:2.7.7.24]
synonym: "dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.24]
synonym: "glucose 1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.24]
synonym: "TDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24]
synonym: "thymidine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24]
synonym: "thymidine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.24]
xref: EC:2.7.7.24
xref: MetaCyc:DTDPGLUCOSEPP-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0008880
name: glucuronate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucuronate = D-fructuronate." [EC:5.3.1.12]
subset: gosubset_prok
synonym: "D-glucuronate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.12]
synonym: "D-glucuronate isomerase activity" EXACT [EC:5.3.1.12]
synonym: "D-glucuronate ketol-isomerase activity" EXACT [EC:5.3.1.12]
synonym: "uronate isomerase activity" EXACT [EC:5.3.1.12]
synonym: "uronic acid isomerase activity" EXACT [EC:5.3.1.12]
synonym: "uronic isomerase activity" EXACT [EC:5.3.1.12]
xref: EC:5.3.1.12
xref: MetaCyc:GLUCUROISOM-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008881
name: glutamate racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate = D-glutamate." [EC:5.1.1.3]
subset: gosubset_prok
xref: EC:5.1.1.3
xref: MetaCyc:GLUTRACE-RXN
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0008882
name: [glutamate-ammonia-ligase] adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (L-glutamate:ammonia ligase (ADP-forming)) = diphosphate + adenylyl-(L-glutamate:ammonia ligase (ADP-forming))." [EC:2.7.7.42]
subset: gosubset_prok
synonym: "adenosine triphosphate:glutamine synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42]
synonym: "ATP:[glutamate-ammonia-ligase] adenylyltransferase activity" EXACT []
synonym: "ATP:glutamine synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42]
synonym: "ATP:L-glutamate:ammonia ligase (ADP-forming) adenylyltransferase activity" EXACT [EC:2.7.7.42]
synonym: "glutamate-ammonia-ligase adenylyltransferase activity" EXACT []
synonym: "glutamine-synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42]
xref: EC:2.7.7.42
xref: MetaCyc:GSADENYLATION-RXN
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0008883
name: glutamyl-tRNA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate 1-semialdehyde + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH + H+." [EC:1.2.1.70, MetaCyc:GLUTRNAREDUCT-RXN]
subset: gosubset_prok
synonym: "L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming)" EXACT [EC:1.2.1.70]
xref: EC:1.2.1.70
xref: MetaCyc:GLUTRNAREDUCT-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008884
name: glutathionylspermidine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine." [EC:3.5.1.78]
subset: gosubset_prok
synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase activity" EXACT [EC:3.5.1.78]
synonym: "glutathionylspermidine amidohydrolase (spermidine-forming) activity" EXACT [EC:3.5.1.78]
synonym: "GSP amidase activity" EXACT [EC:3.5.1.78]
xref: EC:3.5.1.78
xref: MetaCyc:GSPAMID-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008885
name: glutathionylspermidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate." [EC:6.3.1.8]
subset: gosubset_prok
synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule]" RELATED [EC:6.3.1.8]
synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) activity" EXACT [EC:6.3.1.8]
synonym: "glutathione:spermidine ligase (ADP-forming) activity" EXACT [EC:6.3.1.8]
synonym: "glutathionylspermidine synthetase activity" EXACT [EC:6.3.1.8]
synonym: "GSP synthetase activity" EXACT [EC:6.3.1.8]
xref: EC:6.3.1.8
xref: MetaCyc:GSPSYN-RXN
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0008886
name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NADP+ + H2O = 3-phospho-D-glycerate + NADPH + H+." [EC:1.2.1.9]
subset: gosubset_prok
synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase activity" EXACT []
synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate)" BROAD []
synonym: "glyceraldehyde 3-phosphate dehydrogenase (NADP)" EXACT []
synonym: "glyceraldehyde phosphate dehydrogenase (NADP)" BROAD []
synonym: "glyceraldehyde-3-phosphate dehydrogenase (NADP)" EXACT []
synonym: "glyceraldehyde-3-phosphate:NADP reductase activity" EXACT []
synonym: "NADP-glyceraldehyde phosphate dehydrogenase" BROAD []
synonym: "NADP-glyceraldehyde-3-phosphate dehydrogenase activity" EXACT []
synonym: "nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase activity" EXACT []
synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.9]
xref: EC:1.2.1.9
xref: MetaCyc:1.2.1.9-RXN
is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity

[Term]
id: GO:0008887
name: glycerate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (R)-glycerate = ADP + 3-phospho-(R)-glycerate." [EC:2.7.1.31]
subset: gosubset_prok
synonym: "ATP:(R)-glycerate 3-phosphotransferase activity" EXACT [EC:2.7.1.31]
synonym: "ATP:D-glycerate 2-phosphotransferase activity" EXACT [EC:2.7.1.31]
synonym: "D-glycerate 3-kinase activity" EXACT [EC:2.7.1.31]
synonym: "D-glycerate kinase activity" EXACT [EC:2.7.1.31]
synonym: "D-glyceric acid kinase activity" EXACT [EC:2.7.1.31]
synonym: "GK" RELATED [EC:2.7.1.31]
synonym: "glycerate kinase (phosphorylating)" EXACT [EC:2.7.1.31]
synonym: "glycerate-3-kinase activity" EXACT [EC:2.7.1.31]
xref: EC:2.7.1.31
xref: MetaCyc:GLY3KIN-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008888
name: glycerol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol + NAD+ = glycerone + NADH + H+." [EC:1.1.1.6]
subset: gosubset_prok
synonym: "NAD-linked glycerol dehydrogenase activity" EXACT [EC:1.1.1.6]
xref: EC:1.1.1.6
xref: MetaCyc:GLYCDEH-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008889
name: glycerophosphodiester phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46]
subset: gosubset_prok
synonym: "gene hpd protein" RELATED [EC:3.1.4.46]
synonym: "glycerophosphodiester glycerophosphohydrolase activity" EXACT [EC:3.1.4.46]
synonym: "glycerophosphoryl diester phosphodiesterase activity" EXACT [EC:3.1.4.46]
synonym: "IgD-binding protein D" RELATED [EC:3.1.4.46]
xref: EC:3.1.4.46
xref: MetaCyc:GLYCPDIESTER-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0008890
name: glycine C-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + glycine = CoA + 2-amino-3-oxobutanoate." [EC:2.3.1.29]
subset: gosubset_prok
synonym: "2-amino-3-ketobutyrate CoA ligase activity" EXACT [EC:2.3.1.29]
synonym: "2-amino-3-ketobutyrate coenzyme A ligase activity" EXACT [EC:2.3.1.29]
synonym: "2-amino-3-ketobutyrate-CoA ligase activity" EXACT [EC:2.3.1.29]
synonym: "acetyl-CoA:glycine C-acetyltransferase activity" EXACT [EC:2.3.1.29]
synonym: "aminoacetone synthase activity" EXACT [EC:2.3.1.29]
synonym: "glycine acetyltransferase activity" EXACT [EC:2.3.1.29]
xref: EC:2.3.1.29
xref: MetaCyc:AKBLIG-RXN
is_a: GO:0016453 ! C-acetyltransferase activity

[Term]
id: GO:0008891
name: glycolate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycolate + O2 = glyoxylate + H2O2." [EC:1.1.3.15]
subset: gosubset_prok
xref: MetaCyc:RXN-969
xref: Reactome:26481 "glycolate oxidase activity"
is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity

[Term]
id: GO:0008892
name: guanine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanine + H2O = xanthine + NH3." [EC:3.5.4.3]
subset: gosubset_prok
synonym: "GAH activity" EXACT [EC:3.5.4.3]
synonym: "guanase activity" EXACT [EC:3.5.4.3]
synonym: "guanine aminase activity" EXACT [EC:3.5.4.3]
synonym: "guanine aminohydrolase activity" EXACT [EC:3.5.4.3]
xref: EC:3.5.4.3
xref: MetaCyc:GUANINE-DEAMINASE-RXN
xref: Reactome:26482 "guanine deaminase activity"
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0008893
name: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate." [EC:3.1.7.2]
subset: gosubset_prok
synonym: "(ppGpp)ase activity" EXACT [EC:3.1.7.2]
synonym: "guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase activity" EXACT []
synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase activity" EXACT [EC:3.1.7.2]
synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase activity" EXACT []
synonym: "penta-phosphate guanosine-3'-diphosphohydrolase activity" EXACT [EC:3.1.7.2]
synonym: "penta-phosphate guanosine-3'-pyrophosphohydrolase activity" EXACT [EC:3.1.7.2]
synonym: "PpGpp phosphohydrolase activity" EXACT [EC:3.1.7.2]
synonym: "PpGpp-3'-pyrophosphohydrolase activity" EXACT [EC:3.1.7.2]
xref: EC:3.1.7.2
xref: MetaCyc:PPGPPSYN-RXN
is_a: GO:0016794 ! diphosphoric monoester hydrolase activity

[Term]
id: GO:0008894
name: guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate." [EC:3.6.1.40]
subset: gosubset_prok
synonym: "guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase activity" EXACT [EC:3.6.1.40]
synonym: "guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40]
synonym: "guanosine pentaphosphatase activity" EXACT [EC:3.6.1.40]
synonym: "guanosine pentaphosphate phosphatase activity" EXACT [EC:3.6.1.40]
synonym: "guanosine pentaphosphate phosphohydrolase activity" EXACT [EC:3.6.1.40]
synonym: "guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40]
synonym: "guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase activity" EXACT []
synonym: "pppGpp 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40]
xref: EC:3.6.1.40
xref: MetaCyc:PPPGPPHYDRO-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0008897
name: holo-[acyl-carrier-protein] synthase activity
namespace: molecular_function
alt_id: GO:0008958
def: "Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form." [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709]
subset: gosubset_prok
synonym: "4'-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7]
synonym: "4'-phosphopantetheinyltransferase activity" EXACT []
synonym: "AcpS" RELATED [EC:2.7.8.7]
synonym: "ACPS activity" RELATED [EC:2.7.8.7]
synonym: "acyl carrier protein holoprotein (holo-ACP) synthetase activity" EXACT [EC:2.7.8.7]
synonym: "acyl carrier protein synthase activity" RELATED [EC:2.7.8.7]
synonym: "acyl carrier protein synthetase activity" RELATED [EC:2.7.8.7]
synonym: "alpha-aminoadipate reductase phosphopantetheinyl transferase activity" EXACT []
synonym: "alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7]
synonym: "alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7]
synonym: "CoA-[4'-phosphopantetheine]:apo-acyl-carrier-protein 4'-pantetheinephosphotransferase activity" EXACT [EC:2.7.8.7]
synonym: "CoA:apo-acyl-carrier-protein pantetheinephosphotransferase activity" EXACT [EC:2.7.8.7]
synonym: "coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity" EXACT [EC:2.7.8.7]
synonym: "holo-[acyl-carrier-protein] synthase activity" NARROW []
synonym: "holo-[peptidyl-carrier protein] synthase activity" NARROW []
synonym: "holo-ACP synthase activity" RELATED [EC:2.7.8.7]
synonym: "holo-ACP synthetase activity" RELATED [EC:2.7.8.7]
synonym: "holo-acyl-carrier-protein synthase activity" EXACT [EC:2.7.8.7]
synonym: "holosynthase activity" RELATED [EC:2.7.8.7]
synonym: "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" NARROW [EC:2.7.8.7]
synonym: "P-pant transferase activity" EXACT [EC:2.7.8.7]
synonym: "phosphopantetheinyltransferase activity" EXACT []
synonym: "PPTase activity" EXACT [EC:2.7.8.7]
xref: EC:2.7.8.7
xref: MetaCyc:HOLO-ACP-SYNTH-RXN
xref: Reactome:26486 "holo-[acyl-carrier-protein] synthase activity"
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0008898
name: homocysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [EC:2.1.1.10]
subset: gosubset_prok
synonym: "adenosylmethionine transmethylase activity" EXACT [EC:2.1.1.10]
synonym: "adenosylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10]
synonym: "homocysteine methyltransferase activity" EXACT [EC:2.1.1.10]
synonym: "homocysteine transmethylase activity" EXACT [EC:2.1.1.10]
synonym: "L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.10]
synonym: "methylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10]
synonym: "S-adenosyl-L-methionine:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.10]
synonym: "S-adenosyl-L-methionine:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.10]
synonym: "S-adenosylmethionine homocysteine transmethylase activity" EXACT [EC:2.1.1.10]
synonym: "S-adenosylmethionine-homocysteine transmethylase activity" EXACT [EC:2.1.1.10]
synonym: "S-adenosylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10]
synonym: "S-methylmethionine homocysteine transmethylase activity" EXACT [EC:2.1.1.10]
xref: EC:2.1.1.10
xref: MetaCyc:HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008899
name: homoserine O-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine." [EC:2.3.1.46]
subset: gosubset_prok
synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.3.1.46]
synonym: "homoserine succinyltransferase activity" EXACT [EC:2.3.1.46]
synonym: "succinyl-CoA:L-homoserine O-succinyltransferase activity" EXACT [EC:2.3.1.46]
xref: EC:2.3.1.46
xref: MetaCyc:HOMSUCTRAN-RXN
is_a: GO:0016750 ! O-succinyltransferase activity

[Term]
id: GO:0008900
name: hydrogen:potassium-exchanging ATPase activity
namespace: molecular_function
alt_id: GO:0005390
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in)." [EC:3.6.3.10]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "(K+ + H+)-ATPase activity" EXACT [EC:3.6.3.10]
synonym: "ATP phosphohydrolase (H+/K+-exchanging)" EXACT [EC:3.6.3.10]
synonym: "gastric H(+)/K(+) ATPase activity" NARROW [EC:3.6.3.10]
synonym: "gastric H+/K+ ATPase" NARROW [EC:3.6.3.10]
synonym: "H(+)/K(+)-ATPase activity" EXACT [EC:3.6.3.10]
synonym: "H(+)/K(+)-exchanging ATPase activity" EXACT [EC:3.6.3.10]
synonym: "H+-K+-ATPase activity" EXACT [EC:3.6.3.10]
synonym: "H+/K+-ATPase activity" EXACT [EC:3.6.3.10]
synonym: "H+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.10]
synonym: "h+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.10]
synonym: "H,K-ATPase activity" EXACT [EC:3.6.3.10]
synonym: "hydrogen/potassium-exchanging ATPase activity" EXACT []
synonym: "hydrogen:potassium exchanging ATPase activity" EXACT []
synonym: "proton pump activity" BROAD [EC:3.6.3.10]
xref: EC:3.6.3.10
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

[Term]
id: GO:0008901
name: ferredoxin hydrogenase activity
namespace: molecular_function
alt_id: GO:0016948
alt_id: GO:0016949
alt_id: GO:0016950
alt_id: GO:0016951
def: "Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2." [EC:1.12.7.2]
comment: Note that this function was formerly EC 1.12.1.1, EC 1.12.7.1, EC 1.98.1.1, EC 1.18.3.1 and EC 1.18.99.1.
subset: gosubset_prok
synonym: "[Fe] hydrogenase activity" EXACT []
synonym: "[Fe] hydrogenase gamma" RELATED []
synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.7.2]
synonym: "H(2) oxidizing hydrogenase activity" BROAD [EC:1.12.7.2]
synonym: "H(2) producing hydrogenase activity" BROAD [EC:1.12.7.2]
synonym: "H2 oxidizing hydrogenase" BROAD []
synonym: "H2 producing hydrogenase" BROAD []
synonym: "hydrogen-lyase activity" BROAD [EC:1.12.7.2]
synonym: "hydrogen:ferredoxin oxidoreductase activity" EXACT []
synonym: "hydrogenase (ferredoxin) activity" EXACT [EC:1.12.7.2]
synonym: "hydrogenase activity" BROAD []
synonym: "hydrogenase I" RELATED []
synonym: "hydrogenase II" RELATED []
synonym: "hydrogenlyase activity" BROAD [EC:1.12.7.2]
synonym: "iron hydrogenase activity" NARROW []
synonym: "iron-only hydrogenase activity" NARROW []
synonym: "Ni-Fe hydrogenase activity" NARROW []
synonym: "Ni-Fe-Se hydrogenase activity" NARROW []
synonym: "nickel hydrogenase activity" NARROW []
synonym: "nickel-iron hydrogenase activity" NARROW []
synonym: "nickel-iron-selenium hydrogenase activity" NARROW []
synonym: "uptake hydrogenase activity" BROAD [EC:1.12.7.2]
xref: EC:1.12.7.2
xref: MetaCyc:HYDROG-RXN
xref: UM-BBD_enzymeID:e0418
is_a: GO:0016699 ! oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor

[Term]
id: GO:0008902
name: hydroxymethylpyrimidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 4-amino-2-methyl-5-hydroxymethylpyrimidine = ADP + 4-amino-2-methyl-5-phosphomethylpyrimidine." [EC:2.7.1.49]
subset: gosubset_prok
synonym: "ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase activity" EXACT [EC:2.7.1.49]
synonym: "hydroxymethylpyrimidine kinase (phosphorylating)" EXACT [EC:2.7.1.49]
xref: EC:2.7.1.49
xref: MetaCyc:OHMETPYRKIN-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008903
name: hydroxypyruvate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxypyruvate = 2-hydroxy-3-oxopropanoate." [EC:5.3.1.22]
subset: gosubset_prok
synonym: "hydroxypyruvate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.22]
synonym: "hydroxypyruvate ketol-isomerase activity" EXACT [EC:5.3.1.22]
xref: EC:5.3.1.22
xref: MetaCyc:RXN0-305
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0008904
name: aminoglycoside 7''-O-phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + aminoglycoside = ADP + 7''-O-phosphoaminoglycoside." [EC:2.7.1.119, GOC:cb, GOC:mah]
subset: gosubset_prok
synonym: "APH(7'') activity" EXACT [EC:2.7.1.119]
synonym: "ATP:hygromycin-B 7''-O-phosphotransferase activity" NARROW [EC:2.7.1.119]
synonym: "destomic acid ring 7''-O-phosphotransferase activity" EXACT []
synonym: "hygromycin B kinase activity" NARROW []
synonym: "hygromycin B phosphotransferase activity" NARROW [EC:2.7.1.119]
synonym: "hygromycin-B kinase activity" NARROW []
xref: EC:2.7.1.119
xref: MetaCyc:HYGROMYCIN-B-KINASE-RXN
is_a: GO:0034071 ! aminoglycoside phosphotransferase activity

[Term]
id: GO:0008905
name: mannose-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:2.7.7.-
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0008906
name: inosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + inosine = ADP + IMP." [EC:2.7.1.73]
subset: gosubset_prok
synonym: "ATP:inosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.73]
synonym: "inosine kinase (phosphorylating)" EXACT [EC:2.7.1.73]
synonym: "inosine-guanosine kinase activity" RELATED [EC:2.7.1.73]
xref: EC:2.7.1.73
xref: MetaCyc:INOSINEKIN-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008907
name: integrase activity
namespace: molecular_function
def: "Catalysis of the integration of lambdoid phage DNA during establishment, probably by forming a transient DNA-protein link." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_goa
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0008908
name: isochorismatase activity
namespace: molecular_function
def: "Catalysis of the reaction: isochorismate + H2O = 2,3-dihydro-2,3-dihydroxybenzoate + pyruvate." [EC:3.3.2.1]
subset: gosubset_prok
synonym: "2,3 dihydro-2,3 dihydroxybenzoate synthase activity" EXACT [EC:3.3.2.1]
synonym: "2,3-dihydro-2,3-dihydroxybenzoate synthase activity" EXACT [EC:3.3.2.1]
synonym: "2,3-dihydroxy-2,3-dihydrobenzoate synthase activity" EXACT [EC:3.3.2.1]
synonym: "2,3-dihydroxy-2,3-dihydrobenzoic synthase activity" EXACT [EC:3.3.2.1]
synonym: "isochorismate pyruvate-hydrolase activity" EXACT [EC:3.3.2.1]
xref: EC:3.3.2.1
xref: MetaCyc:ISOCHORMAT-RXN
is_a: GO:0004463 ! leukotriene-A4 hydrolase activity

[Term]
id: GO:0008909
name: isochorismate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: chorismate = isochorismate." [EC:5.4.99.6]
comment: Note that this function was formerly EC:5.4.99.6.
subset: gosubset_prok
synonym: "isochorismate hydroxymutase activity" EXACT [EC:5.4.4.2]
synonym: "isochorismate mutase activity" EXACT []
synonym: "isochorismate synthetase activity" EXACT [EC:5.4.4.2]
xref: EC:5.4.4.2
xref: MetaCyc:ISOCHORSYN-RXN
is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups

[Term]
id: GO:0008910
name: kanamycin kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + kanamycin = ADP + kanamycin 3'-phosphate." [EC:2.7.1.95]
subset: gosubset_prok
synonym: "aminoglycoside 3'-phosphotransferase activity" EXACT [EC:2.7.1.95]
synonym: "APH(3') activity" EXACT [EC:2.7.1.95]
synonym: "ATP:kanamycin 3'-O-phosphotransferase activity" EXACT [EC:2.7.1.95]
synonym: "kanamycin kinase (phosphorylating)" EXACT [EC:2.7.1.95]
synonym: "neomycin phosphotransferase activity" EXACT [EC:2.7.1.95]
synonym: "neomycin-kanamycin phosphotransferase activity" EXACT [EC:2.7.1.95]
xref: EC:2.7.1.95
xref: MetaCyc:KANAMYCIN-KINASE-RXN
is_a: GO:0034071 ! aminoglycoside phosphotransferase activity

[Term]
id: GO:0008911
name: lactaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+." [EC:1.2.1.22]
subset: gosubset_prok
synonym: "(S)-lactaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.22]
synonym: "L-lactaldehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.22]
synonym: "nicotinamide adenine dinucleotide (NAD)-linked dehydrogenase activity" EXACT [EC:1.2.1.22]
xref: EC:1.2.1.22
xref: MetaCyc:LACTALDDEHYDROG-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008912
name: lactaldehyde reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R) (or (S))-propane-1,2-diol + NAD+ = (R) (or (S))-lactaldehyde + NADH + H+." [EC:1.1.1.77]
subset: gosubset_prok
synonym: "(R)[or (S)]-propane-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.77]
synonym: "L-lactaldehyde:propanediol oxidoreductase activity" EXACT [EC:1.1.1.77]
synonym: "propanediol oxidoreductase activity" EXACT [EC:1.1.1.77]
synonym: "propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase activity" EXACT [EC:1.1.1.77]
xref: EC:1.1.1.77
xref: MetaCyc:LACTALDREDUCT-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008913
name: lauroyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "lauroyl transferase activity" EXACT []
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0008914
name: leucyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-leucyl-tRNA + protein = tRNA + L-leucyl-protein." [EC:2.3.2.6]
subset: gosubset_prok
synonym: "L-leucyl-tRNA:protein leucyltransferase activity" EXACT [EC:2.3.2.6]
synonym: "L/F transferase activity" EXACT [EC:2.3.2.6]
synonym: "leucyl, phenylalanine-tRNA-protein transferase activity" EXACT [EC:2.3.2.6]
synonym: "leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.6]
synonym: "leucyl-phenylalanine-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.6]
synonym: "leucyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6]
synonym: "leucyl/phenylalanyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6]
xref: EC:2.3.2.6
xref: MetaCyc:LEUCYLTRANSFERASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0008915
name: lipid-A-disaccharide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate." [EC:2.4.1.182]
subset: gosubset_prok
synonym: "UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase activity" EXACT [EC:2.4.1.182]
xref: EC:2.4.1.182
xref: MetaCyc:LIPIDADISACCHARIDESYNTH-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0008917
name: lipopolysaccharide N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide." [EC:2.4.1.56]
subset: gosubset_prok
synonym: "LPS N-acetylglucosaminyltransferase activity" EXACT []
synonym: "UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.56]
synonym: "UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56]
synonym: "uridine diphosphoacetylglucosamine-lipopolysaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56]
xref: EC:2.4.1.56
xref: MetaCyc:2.4.1.56-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0008918
name: lipopolysaccharide 3-alpha-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.44]
subset: gosubset_prok
synonym: "lipopolysaccharide 1,3-galactosyltransferase activity" EXACT [EC:2.4.1.44]
synonym: "lipopolysaccharide galactosyltransferase activity" EXACT []
synonym: "lipopolysaccharide-alpha-1,3-D-galactosyltransferase" NARROW []
synonym: "LPS 3-alpha-galactosyltransferase activity" EXACT []
synonym: "UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.44]
synonym: "UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase activity" EXACT [EC:2.4.1.44]
synonym: "UDP-galactose:polysaccharide galactosyltransferase activity" EXACT [EC:2.4.1.44]
synonym: "UDPgalactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.44]
synonym: "uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase activity" EXACT [EC:2.4.1.44]
synonym: "uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase activity" EXACT [EC:2.4.1.44]
xref: EC:2.4.1.44
xref: MetaCyc:2.4.1.44-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0008919
name: lipopolysaccharide glucosyltransferase I activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide." [EC:2.4.1.58]
subset: gosubset_prok
synonym: "lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58]
synonym: "LPS glucosyltransferase I activity" EXACT []
synonym: "UDP-glucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58]
synonym: "UDPglucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58]
synonym: "UDPglucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58]
synonym: "uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58]
synonym: "uridine diphosphoglucose-lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58]
xref: EC:2.4.1.58
xref: MetaCyc:2.4.1.58-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0008920
name: lipopolysaccharide heptosyltransferase activity
namespace: molecular_function
subset: gosubset_prok
synonym: "LPS heptosyltransferase activity" EXACT []
is_a: GO:0016757 ! transferase activity, transferring glycosyl groups

[Term]
id: GO:0008921
name: lipopolysaccharide-1,6-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide." [GOC:ai]
synonym: "LPS-1,6-galactosyltransferase activity" EXACT []
xref: EC:2.4.1.-
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0008922
name: long-chain-fatty-acid-[acyl-carrier-protein] ligase activity
namespace: molecular_function
alt_id: GO:0010300
def: "Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]." [EC:6.2.1.20]
subset: gosubset_prok
synonym: "acyl-[acyl-carrier-protein] synthetase activity" EXACT [EC:6.2.1.20]
synonym: "acyl-ACP synthetase activity" EXACT []
synonym: "acyl-acyl carrier protein synthetase" BROAD [EC:6.2.1.20]
synonym: "acyl-acyl-carrier-protein synthetase activity" EXACT [EC:6.2.1.20]
synonym: "acyl-acyl-carrier-proteinsynthetase activity" EXACT [EC:6.2.1.20]
synonym: "long-chain fatty acid-[acyl-carrier-protein] ligase activity" EXACT []
synonym: "long-chain-fatty-acid-[acyl-carrier protein] ligase activity" EXACT []
synonym: "long-chain-fatty-acid-ACP ligase activity" EXACT []
synonym: "long-chain-fatty-acid-acyl-carrier-protein ligase activity" EXACT [EC:6.2.1.20]
synonym: "long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity" EXACT [EC:6.2.1.20]
synonym: "stearoyl-ACP synthetase activity" EXACT [EC:6.2.1.20]
xref: EC:6.2.1.20
xref: MetaCyc:ACYLACPSYNTH-RXN
is_a: GO:0015645 ! fatty-acid ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0008923
name: lysine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine = cadaverine + CO2." [EC:4.1.1.18]
subset: gosubset_prok
synonym: "L-lysine carboxy-lyase (cadaverine-forming)" EXACT [EC:4.1.1.18]
synonym: "L-lysine carboxy-lyase activity" EXACT [EC:4.1.1.18]
xref: EC:4.1.1.18
xref: MetaCyc:LYSDECARBOX-RXN
xref: MetaCyc:PWY0-461
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008924
name: malate dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + acceptor = oxaloacetate + reduced acceptor." [EC:1.1.99.16]
subset: gosubset_prok
synonym: "(S)-malate:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.16]
synonym: "(S)-malate:acceptor oxidoreductase activity" EXACT [EC:1.1.99.16]
synonym: "FAD-dependent malate-vitamin K reductase activity" EXACT []
synonym: "malate-vitamin K reductase activity" EXACT []
xref: EC:1.1.99.16
xref: MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN
is_a: GO:0016615 ! malate dehydrogenase activity

[Term]
id: GO:0008925
name: maltose O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose." [EC:2.3.1.79]
subset: gosubset_prok
synonym: "acetyl-CoA:maltose O-acetyltransferase activity" EXACT [EC:2.3.1.79]
synonym: "maltose transacetylase activity" EXACT [EC:2.3.1.79]
xref: EC:2.3.1.79
xref: MetaCyc:MALTACETYLTRAN-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0008926
name: mannitol-1-phosphate 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.17]
subset: gosubset_prok
xref: EC:1.1.1.17
xref: MetaCyc:MANNPDEHYDROG-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008927
name: mannonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O." [EC:4.2.1.8]
subset: gosubset_prok
synonym: "altronate hydrolase activity" EXACT [EC:4.2.1.8]
synonym: "altronic hydro-lyase activity" EXACT [EC:4.2.1.8]
synonym: "D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.2.1.8]
synonym: "D-mannonate hydro-lyase activity" EXACT [EC:4.2.1.8]
synonym: "D-mannonate hydrolyase activity" EXACT [EC:4.2.1.8]
synonym: "mannonate hydrolyase activity" EXACT [EC:4.2.1.8]
synonym: "mannonic hydrolase activity" EXACT [EC:4.2.1.8]
xref: EC:4.2.1.8
xref: MetaCyc:MANNONDEHYDRAT-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0008928
name: mannose-1-phosphate guanylyltransferase (GDP) activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP + D-mannose 1-phosphate = phosphate + GDP-mannose." [EC:2.7.7.22]
subset: gosubset_prok
synonym: "GDP mannose phosphorylase activity" EXACT [EC:2.7.7.22]
synonym: "GDP-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22]
synonym: "GDP-mannose phosphorylase activity" EXACT [EC:2.7.7.22]
synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.22]
synonym: "GDP:alpha-D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22]
synonym: "GDP:D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22]
synonym: "GDP:mannose-1-phosphate guanylyltransferase activity" EXACT []
synonym: "guanosine diphosphate-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22]
synonym: "guanosine diphosphomannose phosphorylase activity" EXACT [EC:2.7.7.22]
synonym: "mannose 1-phosphate (guanosine diphosphate) guanylyltransferase activity" EXACT [EC:2.7.7.22]
synonym: "mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22]
xref: EC:2.7.7.22
xref: MetaCyc:MANNPGUANYLTRANGDP-RXN
is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity

[Term]
id: GO:0008929
name: methylglyoxal synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate." [EC:4.2.3.3]
subset: gosubset_prok
synonym: "glycerone-phosphate phospho-lyase (methylglyoxal-forming)" EXACT [EC:4.2.3.3]
synonym: "glycerone-phosphate phospho-lyase activity" EXACT [EC:4.2.3.3]
synonym: "methylglyoxal synthetase activity" EXACT [EC:4.2.3.3]
xref: EC:4.2.3.3
xref: MetaCyc:METHGLYSYN-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0008930
name: methylthioadenosine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose." [EC:3.2.2.16]
subset: gosubset_prok
synonym: "5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.16]
synonym: "MeSAdo nucleosidase activity" EXACT [EC:3.2.2.16]
synonym: "methylthioadenosine methylthioribohydrolase activity" EXACT [EC:3.2.2.16]
synonym: "MTA nucleosidase activity" EXACT [EC:3.2.2.16]
synonym: "S-methyl-5'-thioadenosine adeninehyrolase activity" EXACT [EC:3.2.2.16]
xref: EC:3.2.2.16
xref: MetaCyc:METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0008931
name: murein DD-endopeptidase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008932
name: lytic endotransglycosylase activity
namespace: molecular_function
def: "Catalysis of the specific cleavage of the beta-1,4 glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends." [PMID:10964424, PMID:9642199]
synonym: "murein lytic endotransglycosylase E activity" NARROW []
xref: EC:2.4.99.-
is_a: GO:0008933 ! lytic transglycosylase activity

[Term]
id: GO:0008933
name: lytic transglycosylase activity
namespace: molecular_function
def: "Catalysis of the specific cleavage of the beta-1,4 glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues." [PMID:10964424]
subset: gosubset_prok
synonym: "murein transglycosylase B activity" NARROW []
synonym: "peptidoglycan lytic transglycosylase activity" EXACT []
xref: EC:3.2.1.-
is_a: GO:0016757 ! transferase activity, transferring glycosyl groups

[Term]
id: GO:0008934
name: inositol-1(or 4)-monophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25]
subset: gosubset_prok
synonym: "inositol 1-phosphatase activity" EXACT [EC:3.1.3.25]
synonym: "inositol monophosphate phosphatase activity" BROAD [EC:3.1.3.25]
synonym: "inositol phosphatase activity" BROAD [EC:3.1.3.25]
synonym: "inositol-phosphate phosphatase activity" EXACT [EC:3.1.3.25]
synonym: "L-myo-inositol-1-phosphate phosphatase activity" EXACT [EC:3.1.3.25]
synonym: "myo-inositol 1-phosphatase activity" EXACT [EC:3.1.3.25]
synonym: "myo-inositol monophosphatase activity" BROAD [EC:3.1.3.25]
synonym: "myo-inositol-1(or 4)-monophosphatase activity" EXACT []
synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.25]
synonym: "myo-inositol-1-phosphatase activity" EXACT [EC:3.1.3.25]
synonym: "myo-inositol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.25]
xref: EC:3.1.3.25
xref: MetaCyc:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN
is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity

[Term]
id: GO:0008935
name: naphthoate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoate + CoA." [EC:4.1.3.36]
subset: gosubset_prok
synonym: "1,4-dihydroxy-2-naphthoate synthase activity" EXACT [EC:4.1.3.36]
synonym: "DHNA synthetase activity" EXACT [EC:4.1.3.36]
synonym: "dihydroxynaphthoate synthase activity" EXACT [EC:4.1.3.36]
synonym: "dihydroxynaphthoic acid synthetase activity" EXACT [EC:4.1.3.36]
synonym: "o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing) activity" EXACT [EC:4.1.3.36]
synonym: "o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing; CoA-forming)" EXACT [EC:4.1.3.36]
xref: EC:4.1.3.36
xref: MetaCyc:NAPHTHOATE-SYN-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0008936
name: nicotinamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3." [EC:3.5.1.19]
subset: gosubset_prok
synonym: "NAMase activity" EXACT [EC:3.5.1.19]
synonym: "namase activity" EXACT [EC:3.5.1.19]
synonym: "nicotinamide amidase activity" EXACT [EC:3.5.1.19]
synonym: "nicotinamide amidohydrolase activity" EXACT [EC:3.5.1.19]
synonym: "nicotinamide deaminase activity" EXACT [EC:3.5.1.19]
synonym: "nicotine deamidase activity" EXACT [EC:3.5.1.19]
synonym: "YNDase activity" EXACT [EC:3.5.1.19]
xref: EC:3.5.1.19
xref: MetaCyc:NICOTINAMID-RXN
xref: Reactome:1714 "nicotinamidase activity"
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008937
name: ferredoxin reductase activity
namespace: molecular_function
def: "Catalysis of the reactions: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+." [EC:1.18.1.-]
subset: gosubset_prok
xref: EC:1.18.1.-
is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor

[Term]
id: GO:0008938
name: nicotinate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + nicotinate = S-adenosyl-L-homocysteine + N-methylnicotinate." [EC:2.1.1.7]
synonym: "furanocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.7]
synonym: "S-adenosyl-L-methionine:nicotinate N-methyltransferase activity" EXACT [EC:2.1.1.7]
xref: EC:2.1.1.7
xref: MetaCyc:NICOTINATE-N-METHYLTRANSFERASE-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008939
name: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-nicotinate D-ribonucleotide + dimethylbenzimidazole = nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole." [EC:2.4.2.21]
subset: gosubset_prok
synonym: "CobT" RELATED [EC:2.4.2.21]
synonym: "N(1)-alpha-phosphoribosyltransferase activity" EXACT [EC:2.4.2.21]
synonym: "N1-alpha-phosphoribosyltransferase activity" EXACT [EC:2.4.2.21]
synonym: "nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase activity" EXACT [EC:2.4.2.21]
synonym: "nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase activity" EXACT [EC:2.4.2.21]
synonym: "nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase activity" EXACT [EC:2.4.2.21]
synonym: "nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.21]
synonym: "nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.21]
xref: EC:2.4.2.21
xref: MetaCyc:DMBPPRIBOSYLTRANS-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0008940
name: nitrate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NO2- (nitrite) + acceptor = NO3- (nitrate) + reduced acceptor." [EC:1.7.99.4]
subset: gosubset_prok
synonym: "nitrate reductase (acceptor)" EXACT [EC:1.7.99.4]
synonym: "nitrite:(acceptor) oxidoreductase" EXACT [EC:1.7.99.4]
synonym: "nitrite:acceptor oxidoreductase" EXACT [EC:1.7.99.4]
synonym: "respiratory nitrate reductase activity" NARROW [EC:1.7.99.4]
xref: EC:1.7.99.4
xref: MetaCyc:NITRATREDUCT-RXN
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0008941
name: nitric oxide dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 NO3- + NADP+." [EC:1.14.12.17]
subset: gosubset_prok
synonym: "nitric oxide,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.12.17]
synonym: "NOD activity" EXACT [EC:1.14.12.17]
xref: EC:1.14.12.17
xref: MetaCyc:R621-RXN
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0008942
name: nitrite reductase [NAD(P)H] activity
namespace: molecular_function
def: "Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = NO2(-) (nitrite) + 3 NAD(P)H + 3 H+." [EC:1.7.1.4]
comment: Note that this function was formerly EC:1.6.6.4.
subset: gosubset_prok
synonym: "ammonium-hydroxide:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.4]
synonym: "assimilatory nitrite reductase activity" RELATED [EC:1.7.1.4]
synonym: "NAD(P)H2:nitrite oxidoreductase activity" EXACT [EC:1.7.1.4]
synonym: "NAD(P)H:nitrite oxidoreductase activity" EXACT [EC:1.7.1.4]
synonym: "NADH-nitrite oxidoreductase activity" EXACT [EC:1.7.1.4]
synonym: "NADPH-nitrite reductase activity" EXACT [EC:1.7.1.4]
synonym: "nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.7.1.4]
synonym: "nitrite reductase [NAD(P)H2]" RELATED [EC:1.7.1.4]
xref: EC:1.7.1.4
xref: MetaCyc:NITRITREDUCT-RXN
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0008943
name: glyceraldehyde-3-phosphate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+." [EC:1.2.1.12, EC:1.2.1.13, EC:1.2.1.9]
comment: Note that the reaction with phosphate as a substrate produces 3-phospho-D-glyceroyl-phosphate.
subset: gosubset_prok
xref: EC:1.2.1.-
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008944
name: oligopeptidase A activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5." [EC:3.4.24.70]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "68000-M signalpeptide hydrolase activity" EXACT [EC:3.4.24.70]
xref: EC:3.4.24.70
xref: MetaCyc:3.4.24.70-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008945
name: oligopeptidase B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline." [EC:3.4.21.83]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "Escherichia coli alkaline proteinase II" RELATED [EC:3.4.21.83]
synonym: "protease II activity" EXACT [EC:3.4.21.83]
xref: EC:3.4.21.83
xref: MetaCyc:3.4.21.83-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008946
name: oligonucleotidase activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates." [EC:3.1.13.3]
comment: Note that enzymes with this activity usually also hydrolyze NAD+ to NMN and AMP.
subset: gosubset_prok
xref: EC:3.1.13.3
xref: MetaCyc:3.1.13.3-RXN
is_a: GO:0004518 ! nuclease activity

[Term]
id: GO:0008947
name: omptin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys." [EC:3.4.21.87]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
xref: EC:3.4.21.87
xref: MetaCyc:3.4.21.87-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008948
name: oxaloacetate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxaloacetate = pyruvate + CO2." [EC:4.1.1.3]
subset: gosubset_prok
synonym: "oxalacetic acid decarboxylase activity" EXACT [EC:4.1.1.3]
synonym: "oxalate beta-decarboxylase activity" EXACT [EC:4.1.1.3]
synonym: "oxaloacetate beta-decarboxylase activity" EXACT [EC:4.1.1.3]
synonym: "oxaloacetate carboxy-lyase (pyruvate-forming)" EXACT [EC:4.1.1.3]
synonym: "oxaloacetate carboxy-lyase activity" EXACT [EC:4.1.1.3]
xref: EC:4.1.1.3
xref: MetaCyc:OXALODECARB-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008949
name: oxalyl-CoA decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxalyl-CoA = formyl-CoA + CO2." [EC:4.1.1.8]
subset: gosubset_prok
synonym: "oxalyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.8]
synonym: "oxalyl-CoA carboxy-lyase (formyl-CoA-forming)" EXACT [EC:4.1.1.8]
synonym: "oxalyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.8]
xref: EC:4.1.1.8
xref: MetaCyc:OXALYL-COA-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0008950
name: p-aminobenzoate synthetase
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc]
comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered.
is_obsolete: true
consider: GO:0008696
consider: GO:0046820

[Term]
id: GO:0008951
name: palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity
namespace: molecular_function
synonym: "palmitoleoyl ACP-dependent acyltransferase activity" EXACT []
xref: EC:2.3.1.-
xref: MetaCyc:PALMITOTRANS-RXN
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0008953
name: penicillin amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate." [EC:3.5.1.11]
subset: gosubset_prok
synonym: "alpha-acylamino-beta-lactam acylhydrolase activity" EXACT [EC:3.5.1.11]
synonym: "ampicillin acylase activity" EXACT [EC:3.5.1.11]
synonym: "benzylpenicillin acylase activity" EXACT [EC:3.5.1.11]
synonym: "novozym 217" RELATED [EC:3.5.1.11]
synonym: "palmitoleoyl [acyl-carrier protein]-dependent acyltransferase activity" EXACT []
synonym: "penicillin acylase activity" EXACT [EC:3.5.1.11]
synonym: "penicillin amidohydrolase activity" EXACT [EC:3.5.1.11]
synonym: "semacylase activity" EXACT [EC:3.5.1.11]
xref: EC:3.5.1.11
xref: MetaCyc:PENICILLIN-AMIDASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0008954
name: peptidoglycan synthetase activity
namespace: molecular_function
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0008955
name: peptidoglycan glycosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate." [EC:2.4.1.129]
subset: gosubset_prok
synonym: "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.129]
synonym: "penicillin binding protein (3 or 1B) activity" NARROW [EC:2.4.1.129]
synonym: "peptidoglycan TGase activity" EXACT [EC:2.4.1.129]
synonym: "peptidoglycan transglycosylase activity" EXACT [EC:2.4.1.129]
synonym: "PG-II activity" EXACT [EC:2.4.1.129]
synonym: "undecaprenyldiphospho-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase activity" EXACT [EC:2.4.1.129]
xref: EC:2.4.1.129
xref: MetaCyc:2.4.1.129-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0008956
name: peptidyl-dipeptidase Dcp activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly." [EC:3.4.15.5]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "dipeptidyl carboxypeptidase (Dcp)" EXACT [EC:3.4.15.5]
synonym: "dipeptidyl carboxypeptidase activity" EXACT [EC:3.4.15.5]
xref: EC:3.4.15.5
xref: MetaCyc:3.4.15.5-RXN
is_obsolete: true
replaced_by: GO:0008235
replaced_by: GO:0008241

[Term]
id: GO:0008957
name: phenylacetaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+." [EC:1.2.1.39]
subset: gosubset_prok
synonym: "phenylacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.39]
xref: EC:1.2.1.39
xref: MetaCyc:PHENDEHYD-RXN
xref: UM-BBD_enzymeID:e0119
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008959
name: phosphate acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate." [EC:2.3.1.8]
subset: gosubset_prok
synonym: "acetyl-CoA:phosphate acetyltransferase activity" EXACT [EC:2.3.1.8]
synonym: "phosphoacylase activity" EXACT [EC:2.3.1.8]
synonym: "phosphotransacetylase activity" EXACT [EC:2.3.1.8]
synonym: "PTA" RELATED [EC:2.3.1.8]
xref: EC:2.3.1.8
xref: MetaCyc:PHOSACETYLTRANS-RXN
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0008960
name: phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose." [EC:2.7.8.20]
subset: gosubset_prok
synonym: "oligosaccharide glycerophosphotransferase activity" EXACT [EC:2.7.8.20]
synonym: "phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" EXACT [EC:2.7.8.20]
synonym: "phosphoglycerol transferase activity" RELATED [EC:2.7.8.20]
synonym: "phosphoglycerol transferase I" RELATED [EC:2.7.8.20]
xref: EC:2.7.8.20
xref: MetaCyc:PGLYCEROLTRANSI-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0008961
name: phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity
namespace: molecular_function
subset: gosubset_prok
is_a: GO:0016757 ! transferase activity, transferring glycosyl groups

[Term]
id: GO:0008962
name: phosphatidylglycerophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate." [EC:3.1.3.27]
subset: gosubset_prok
synonym: "PGP phosphatase activity" EXACT [EC:3.1.3.27]
synonym: "phosphatidylglycerol phosphatase activity" EXACT [EC:3.1.3.27]
synonym: "phosphatidylglycerol phosphate phosphatase activity" EXACT [EC:3.1.3.27]
synonym: "phosphatidylglycerophosphate phosphohydrolase activity" EXACT [EC:3.1.3.27]
xref: EC:3.1.3.27
xref: MetaCyc:PGPPHOSPHA-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0008963
name: phospho-N-acetylmuramoyl-pentapeptide-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol." [EC:2.7.8.13]
subset: gosubset_prok
synonym: "MraY transferase activity" NARROW [EC:2.7.8.13]
synonym: "phospho-MurNAc-pentapeptide transferase activity" EXACT [EC:2.7.8.13]
synonym: "phospho-N-acetylmuramoyl pentapeptide translocase activity" EXACT [EC:2.7.8.13]
synonym: "phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity" EXACT [EC:2.7.8.13]
synonym: "phosphoacetylmuramoylpentapeptide translocase activity" EXACT [EC:2.7.8.13]
synonym: "phosphoacetylmuramoylpentapeptidetransferase activity" EXACT [EC:2.7.8.13]
synonym: "UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity" EXACT [EC:2.7.8.13]
synonym: "UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13]
synonym: "UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13]
synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13]
synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13]
synonym: "UDP-MurNAc-pentapeptide phosphotransferase activity" EXACT [EC:2.7.8.13]
xref: EC:2.7.8.13
xref: MetaCyc:PHOSNACMURPENTATRANS-RXN
xref: MetaCyc:RXN-8975
xref: MetaCyc:RXN-9671
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0008964
name: phosphoenolpyruvate carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphate + oxaloacetate = H2O + phosphoenolpyruvate + CO2." [EC:4.1.1.31]
subset: gosubset_prok
synonym: "PEP carboxylase activity" EXACT [EC:4.1.1.31]
synonym: "PEPC" RELATED [EC:4.1.1.31]
synonym: "PEPCase activity" EXACT [EC:4.1.1.31]
synonym: "phosphate:oxaloacetate carboxy-lyase (adding phosphate; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.31]
synonym: "phosphate:oxaloacetate carboxy-lyase (phosphorylating)" EXACT [EC:4.1.1.31]
synonym: "phosphoenolpyruvic carboxylase activity" EXACT [EC:4.1.1.31]
synonym: "phosphopyruvate (phosphate) carboxylase activity" EXACT [EC:4.1.1.31]
xref: EC:4.1.1.31
xref: MetaCyc:PEPCARBOX-RXN
is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity

[Term]
id: GO:0008965
name: phosphoenolpyruvate-protein phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine." [EC:2.7.3.9]
subset: gosubset_prok
synonym: "enzyme I of the phosphotransferase system" NARROW [EC:2.7.3.9]
synonym: "phosphoenolpyruvate sugar phosphotransferase enzyme I activity" EXACT [EC:2.7.3.9]
synonym: "phosphoenolpyruvate--protein phosphatase activity" EXACT [EC:2.7.3.9]
synonym: "phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase activity" EXACT [EC:2.7.3.9]
synonym: "phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.3.9]
synonym: "phosphopyruvate--protein factor phosphotransferase activity" EXACT [EC:2.7.3.9]
synonym: "phosphopyruvate--protein phosphotransferase activity" EXACT [EC:2.7.3.9]
synonym: "sugar--PEP phosphotransferase enzyme I activity" NARROW [EC:2.7.3.9]
xref: EC:2.7.3.9
xref: MetaCyc:2.7.3.9-RXN
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0008966
name: phosphoglucosamine mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucosamine 1-phosphate = D-glucosamine 6-phosphate." [EC:5.4.2.10]
subset: gosubset_prok
synonym: "alpha-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.10]
synonym: "D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.10]
xref: EC:5.4.2.10
xref: MetaCyc:5.4.2.10-RXN
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0008967
name: phosphoglycolate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate." [EC:3.1.3.18]
subset: gosubset_prok
synonym: "2-phosphoglycolate phosphatase activity" EXACT [EC:3.1.3.18]
synonym: "2-phosphoglycolate phosphohydrolase activity" EXACT [EC:3.1.3.18]
synonym: "P-glycolate phosphatase activity" EXACT [EC:3.1.3.18]
synonym: "phosphoglycolate hydrolase activity" EXACT [EC:3.1.3.18]
synonym: "phosphoglycollate phosphatase activity" EXACT [EC:3.1.3.18]
xref: EC:3.1.3.18
xref: MetaCyc:GPH-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0008968
name: D-sedoheptulose 7-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate." [MetaCyc:RXN0-4301, PMID:11279237, PMID:8631969]
subset: gosubset_prok
synonym: "phosphoheptose isomerase activity" EXACT []
xref: MetaCyc:RXN0-4301
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0008969
name: phosphohistidine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphohistidine + H2O = histidine + phosphate." [GOC:mah]
subset: gosubset_prok
xref: EC:3.1.3.-
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0008970
name: phospholipase A1 activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32]
subset: gosubset_prok
synonym: "phosphatidylcholine 1-acylhydrolase activity" EXACT [EC:3.1.1.32]
xref: EC:3.1.1.32
xref: MetaCyc:PHOSPHOLIPASE-A1-RXN
is_a: GO:0004091 ! carboxylesterase activity
is_a: GO:0004620 ! phospholipase activity

[Term]
id: GO:0008972
name: phosphomethylpyrimidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine." [EC:2.7.4.7]
subset: gosubset_prok
synonym: "ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase activity" EXACT [EC:2.7.4.7]
synonym: "hydroxymethylpyrimidine phosphokinase activity" EXACT [EC:2.7.4.7]
xref: EC:2.7.4.7
xref: MetaCyc:PYRIMSYN3-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0008973
name: phosphopentomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate." [EC:5.4.2.7]
subset: gosubset_prok
synonym: "alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate phosphotransferase activity" EXACT [EC:5.4.2.7]
synonym: "alpha-D-ribose 1,5-phosphomutase activity" EXACT [EC:5.4.2.7]
synonym: "D-ribose 1,5-phosphomutase activity" EXACT [EC:5.4.2.7]
synonym: "deoxyribomutase activity" RELATED [EC:5.4.2.7]
synonym: "deoxyribose phosphomutase activity" RELATED [EC:5.4.2.7]
synonym: "phosphodeoxyribomutase activity" RELATED [EC:5.4.2.7]
synonym: "phosphoribomutase activity" EXACT [EC:5.4.2.7]
xref: EC:5.4.2.7
xref: MetaCyc:PPENTOMUT-RXN
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0008974
name: phosphoribulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate." [EC:2.7.1.19]
subset: gosubset_prok
synonym: "5-phosphoribulose kinase activity" EXACT [EC:2.7.1.19]
synonym: "ATP:D-ribulose-5-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.19]
synonym: "phosphopentokinase activity" RELATED [EC:2.7.1.19]
synonym: "phosphoribulokinase (phosphorylating)" EXACT [EC:2.7.1.19]
synonym: "PKK" RELATED [EC:2.7.1.19]
synonym: "PRK" RELATED [EC:2.7.1.19]
synonym: "PRuK" RELATED [EC:2.7.1.19]
synonym: "ribulose phosphate kinase activity" EXACT [EC:2.7.1.19]
synonym: "ribulose-5-phosphate kinase activity" EXACT [EC:2.7.1.19]
xref: EC:2.7.1.19
xref: MetaCyc:PHOSPHORIBULOKINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0008975
name: pitrilysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon." [EC:3.4.24.55]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "Escherichia coli metalloproteinase Pi" RELATED [EC:3.4.24.55]
synonym: "Escherichia coli protease III" RELATED [EC:3.4.24.55]
synonym: "protease III activity" EXACT [EC:3.4.24.55]
synonym: "protease Pi activity" EXACT [EC:3.4.24.55]
synonym: "proteinase Pi" RELATED [EC:3.4.24.55]
synonym: "PTR" RELATED [EC:3.4.24.55]
xref: EC:3.4.24.55
xref: MetaCyc:3.4.24.55-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0008976
name: polyphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)." [EC:2.7.4.1]
subset: gosubset_prok
synonym: "ATP-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.1]
synonym: "ATP:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.1]
synonym: "polyphosphate polymerase activity" EXACT [GOC:curators]
synonym: "polyphosphoric acid kinase activity" EXACT [EC:2.7.4.1]
xref: EC:2.7.4.1
xref: MetaCyc:POLYPHOSPHATE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0008977
name: prephenate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH + H+." [EC:1.3.1.12]
subset: gosubset_prok
synonym: "chorismate mutase--prephenate dehydrogenase activity" EXACT [EC:1.3.1.12]
synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:1.3.1.12]
synonym: "prephenate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.12]
xref: EC:1.3.1.12
xref: MetaCyc:PREPHENATEDEHYDROG-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0008978
name: prepilin peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine." [EC:3.4.23.43]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
xref: EC:3.4.23.43
xref: MetaCyc:3.4.23.43-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0008979
name: prophage integrase activity
namespace: molecular_function
subset: gosubset_prok
is_a: GO:0008907 ! integrase activity

[Term]
id: GO:0008980
name: propionate kinase activity
namespace: molecular_function
def: "Catalysis of the reactions: (1) ATP + propanoate = ADP + propanoyl phosphate (2) ATP + acetate = ADP + acetyl phosphate." [EC:2.7.2.15]
subset: gosubset_prok
synonym: "ATP:propanoate phosphotransferase activity" EXACT []
synonym: "PduW" RELATED []
synonym: "propanoate kinase activity" EXACT []
synonym: "propionate/acetate kinase activity" EXACT []
synonym: "TdcD" RELATED []
xref: EC:2.7.2.15
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0008981
name: protease IV activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008982
name: protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
namespace: molecular_function
alt_id: GO:0015455
alt_id: GO:0015456
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-]
subset: gosubset_prok
synonym: "enzyme II of the phosphotransferase system" NARROW [EC:2.7.1.69]
synonym: "enzyme IIl4ac" RELATED [EC:2.7.1.69]
synonym: "gene bglC RNA formation factors" RELATED [EC:2.7.1.69]
synonym: "gene glC proteins" RELATED [EC:2.7.1.69]
synonym: "group translocator activity" RELATED [EC:2.7.1.69]
synonym: "PEP--sugar phosphotransferase enzyme II activity" NARROW [EC:2.7.1.69]
synonym: "PEP-dependent phosphotransferase enzyme II" RELATED [EC:2.7.1.69]
synonym: "phosphoenolpyruvate-sugar phosphotransferase enzyme II" RELATED [EC:2.7.1.69]
synonym: "phosphohistidinoprotein-hexose phosphoribosyltransferase activity" EXACT [EC:2.7.1.69]
synonym: "phosphohistidinoprotein-hexose phosphotransferase activity" EXACT [EC:2.7.1.69]
synonym: "phosphoprotein factor-hexose phosophotransferase activity" EXACT [EC:2.7.1.69]
synonym: "phosphotransfer-driven group translocator" EXACT []
synonym: "phosphotransferase, phosphohistidinoprotein-hexose activity" EXACT [EC:2.7.1.69]
synonym: "protein, specific or class, gene bglC" RELATED [EC:2.7.1.69]
synonym: "protein-Np-phosphohistidine-sugar phosphotransferase activity" EXACT []
synonym: "protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity" EXACT [EC:2.7.1.69]
synonym: "protein-Npi-phospho-L-histidine:sugar Npi-phosphotransferase activity" EXACT [EC:2.7.1.69]
synonym: "protein-Npi-phosphohistidine-sugar phosphotransferase activity" EXACT [EC:2.7.1.69]
synonym: "protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity" EXACT [EC:2.7.1.69]
synonym: "PTS permease activity" EXACT [EC:2.7.1.69]
synonym: "PTS transporter" RELATED [EC:2.7.1.69]
synonym: "ribonucleic acid formation factor, gene glC" RELATED [EC:2.7.1.69]
synonym: "sucrose phosphotransferase system II" RELATED [EC:2.7.1.69]
xref: EC:2.7.1.69
xref: MetaCyc:2.7.1.69-RXN
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0008983
name: protein-glutamate O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester." [EC:2.1.1.80, RESID:AA0072]
subset: gosubset_prok
synonym: "MCP methyltransferase I" RELATED [EC:2.1.1.80]
synonym: "MCP methyltransferase II" RELATED [EC:2.1.1.80]
synonym: "methyl-accepting chemotaxis protein methyltransferase II" RELATED [EC:2.1.1.80]
synonym: "methyl-accepting chemotaxis protein O-methyltransferase activity" NARROW [EC:2.1.1.80]
synonym: "protein carboxyl-methylase activity" EXACT [EC:2.1.1.80]
synonym: "protein carboxyl-O-methyltransferase activity" EXACT [EC:2.1.1.80]
synonym: "protein carboxylmethyltransferase II" RELATED [EC:2.1.1.80]
synonym: "protein carboxymethylase activity" EXACT [EC:2.1.1.80]
synonym: "protein carboxymethyltransferase activity" EXACT [EC:2.1.1.80]
synonym: "protein methylase II" RELATED [EC:2.1.1.80]
synonym: "protein O-methyltransferase activity" EXACT [EC:2.1.1.80]
synonym: "protein(aspartate)methyltransferase activity" EXACT [EC:2.1.1.80]
synonym: "protein(carboxyl)methyltransferase activity" EXACT [EC:2.1.1.80]
synonym: "S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase activity" EXACT [EC:2.1.1.80]
synonym: "S-adenosylmethionine-glutamyl methyltransferase activity" EXACT [EC:2.1.1.80]
synonym: "S-adenosylmethionine:protein-carboxyl O-methyltransferase activity" EXACT [EC:2.1.1.80]
xref: EC:2.1.1.80
xref: MetaCyc:CHER-RXN
xref: RESID:AA0072
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0008984
name: protein-glutamate methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol." [EC:3.1.1.61, RESID:AA0072]
subset: gosubset_prok
synonym: "CheB methylesterase activity" NARROW [EC:3.1.1.61]
synonym: "chemotaxis-specific methylesterase activity" NARROW [EC:3.1.1.61]
synonym: "methyl-accepting chemotaxis protein methyl-esterase activity" NARROW [EC:3.1.1.61]
synonym: "methylesterase CheB activity" NARROW [EC:3.1.1.61]
synonym: "protein-L-glutamate-5-O-methyl-ester acylhydrolase activity" EXACT [EC:3.1.1.61]
synonym: "protein-L-glutamate-O5-methyl-ester acylhydrolase activity" EXACT [EC:3.1.1.61]
xref: EC:3.1.1.61
xref: MetaCyc:MCPMETEST-RXN
xref: RESID:AA0072
is_a: GO:0051723 ! protein methylesterase activity

[Term]
id: GO:0008985
name: pyruvate dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + ferricytochrome b1 + H2O = CO2 + acetate + ferrocytochrome b1." [EC:1.2.2.2]
subset: gosubset_prok
synonym: "pyruvate:ferricytochrome-b1 oxidoreductase activity" EXACT [EC:1.2.2.2]
synonym: "pyruvate:ubiquinone-8-oxidoreductase activity" EXACT [EC:1.2.2.2]
synonym: "pyruvic (cytochrome b1) dehydrogenase activity" EXACT [EC:1.2.2.2]
xref: EC:1.2.2.2
xref: MetaCyc:PYRUVOXID-RXN
is_a: GO:0004738 ! pyruvate dehydrogenase activity
is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor

[Term]
id: GO:0008986
name: pyruvate, water dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pyruvate + H2O = AMP + phosphoenolpyruvate + phosphate." [EC:2.7.9.2]
subset: gosubset_prok
synonym: "ATP:pyruvate, water phosphotransferase activity" EXACT [EC:2.7.9.2]
synonym: "PEP synthase activity" EXACT []
synonym: "PEP synthetase activity" EXACT [EC:2.7.9.2]
synonym: "phoephoenolpyruvate synthetase activity" EXACT [EC:2.7.9.2]
synonym: "phosphoenolpyruvate synthase activity" EXACT [EC:2.7.9.2]
synonym: "phosphoenolpyruvic synthase activity" EXACT [EC:2.7.9.2]
synonym: "phosphopyruvate synthetase activity" EXACT [EC:2.7.9.2]
synonym: "pyruvate,water dikinase activity" EXACT [EC:2.7.9.2]
synonym: "pyruvate-water dikinase (phosphorylating)" EXACT [EC:2.7.9.2]
synonym: "water pyruvate dikinase activity" EXACT []
xref: EC:2.7.9.2
xref: MetaCyc:PEPSYNTH-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0008987
name: quinolinate synthetase A activity
namespace: molecular_function
def: "Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate." [GOC:jl, MetaCyc:QUINOLINATE-SYNTHA-RXN]
subset: gosubset_prok
xref: MetaCyc:QUINOLINATE-SYNTHA-RXN
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0008988
name: rRNA (adenine-N6-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine." [EC:2.1.1.48]
subset: gosubset_prok
synonym: "ErmC 23S rRNA methyltransferase" NARROW [EC:2.1.1.48]
synonym: "gene ksgA methyltransferase" NARROW [EC:2.1.1.48]
synonym: "ribonucleic acid-adenine (N(6)) methylase activity" EXACT [EC:2.1.1.48]
synonym: "ribonucleic acid-adenine (N6) methylase activity" EXACT [EC:2.1.1.48]
synonym: "ribosomal ribonucleate adenine 6-methyltransferase activity" EXACT [EC:2.1.1.48]
synonym: "S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.48]
synonym: "S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.48]
xref: EC:2.1.1.48
xref: MetaCyc:RRNA-ADENINE-N6--METHYLTRANSFERASE-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity

[Term]
id: GO:0008989
name: rRNA (guanine-N1-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine." [EC:2.1.1.51]
subset: gosubset_prok
synonym: "ribosomal ribonucleate guanine 1-methyltransferase activity" EXACT [EC:2.1.1.51]
synonym: "S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.51]
synonym: "S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.51]
xref: EC:2.1.1.51
xref: MetaCyc:RRNA-GUANINE-N1--METHYLTRANSFERASE-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity

[Term]
id: GO:0008990
name: rRNA (guanine-N2-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine." [EC:2.1.1.52]
subset: gosubset_prok
synonym: "ribosomal ribonucleate guanine-2-methyltransferase activity" EXACT [EC:2.1.1.52]
synonym: "S-adenosyl-L-methionine:rRNA (guanine-2-N-)-methyltransferase activity" EXACT [EC:2.1.1.52]
synonym: "S-adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase activity" EXACT [EC:2.1.1.52]
xref: EC:2.1.1.52
xref: MetaCyc:RRNA-GUANINE-N2--METHYLTRANSFERASE-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity

[Term]
id: GO:0008991
name: serine-type signal peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism." [GOC:mah]
comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products.
xref: EC:3.4.21.-
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008992
name: repressor LexA activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA." [EC:3.4.21.88]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "LexA repressor" RELATED [EC:3.4.21.88]
synonym: "repressor lexA" RELATED [EC:3.4.21.88]
xref: EC:3.4.21.88
xref: MetaCyc:3.4.21.88-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0008993
name: rhamnulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate." [EC:2.7.1.5]
subset: gosubset_prok
synonym: "ATP:L-rhamnulose 1-phosphotransferase activity" EXACT [EC:2.7.1.5]
synonym: "L-rhamnulokinase activity" EXACT [EC:2.7.1.5]
synonym: "L-rhamnulose kinase activity" EXACT [EC:2.7.1.5]
synonym: "rhamnulokinase (phosphorylating)" EXACT [EC:2.7.1.5]
synonym: "rhamnulose kinase activity" EXACT [EC:2.7.1.5]
synonym: "RhuK" RELATED [EC:2.7.1.5]
xref: EC:2.7.1.5
xref: MetaCyc:RHAMNULOKIN-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0008994
name: rhamnulose-1-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde." [EC:4.1.2.19]
subset: gosubset_prok
synonym: "L-rhamnulose 1-phosphate aldolase activity" EXACT [EC:4.1.2.19]
synonym: "L-rhamnulose-1-phosphate lactaldehyde-lyase activity" EXACT [EC:4.1.2.19]
synonym: "L-rhamnulose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.19]
synonym: "L-rhamnulose-phosphate aldolase activity" EXACT [EC:4.1.2.19]
synonym: "rhamnulose phosphate aldolase activity" EXACT [EC:4.1.2.19]
xref: EC:4.1.2.19
xref: MetaCyc:RHAMNULPALDOL-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0008995
name: ribonuclease E activity
namespace: molecular_function
def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990]
subset: gosubset_prok
xref: MetaCyc:3.1.26.12-RXN
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0008996
name: ribonuclease G activity
namespace: molecular_function
def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990]
subset: gosubset_prok
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0008997
name: ribonuclease R activity
namespace: molecular_function
def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides." [PMID:11948193]
subset: gosubset_prok
xref: EC:3.1.11.-
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0008998
name: ribonucleoside-triphosphate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin." [EC:1.17.4.2]
subset: gosubset_prok
synonym: "2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.2]
synonym: "2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.2]
synonym: "ribonucleotide reductase activity" BROAD [EC:1.17.4.2]
xref: EC:1.17.4.2
xref: MetaCyc:1.17.4.2-RXN
is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor

[Term]
id: GO:0008999
name: ribosomal-protein-alanine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N-acetyl-L-alanine." [EC:2.3.1.128]
subset: gosubset_prok
synonym: "acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase activity" EXACT [EC:2.3.1.128]
synonym: "ribosomal protein S18 acetyltransferase activity" EXACT [EC:2.3.1.128]
xref: EC:2.3.1.128
xref: MetaCyc:2.3.1.128-RXN
is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity

[Term]
id: GO:0009000
name: selenocysteine lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor." [EC:4.4.1.16]
subset: gosubset_prok
synonym: "L-selenocysteine selenide-lyase (L-alanine-forming)" EXACT [EC:4.4.1.16]
synonym: "selenocysteine beta-lyase activity" EXACT [EC:4.4.1.16]
synonym: "selenocysteine reductase activity" EXACT [EC:4.4.1.16]
xref: EC:4.4.1.16
xref: MetaCyc:SELENOCYSTEINE-LYASE-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0009001
name: serine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + L-serine = CoA + O-acetyl-L-serine." [EC:2.3.1.30]
subset: gosubset_prok
synonym: "acetyl-CoA:L-serine O-acetyltransferase activity" EXACT [EC:2.3.1.30]
synonym: "L-serine acetyltransferase activity" EXACT [EC:2.3.1.30]
synonym: "SATase activity" EXACT [EC:2.3.1.30]
synonym: "serine acetyltransferase activity" EXACT [EC:2.3.1.30]
synonym: "serine transacetylase activity" EXACT [EC:2.3.1.30]
xref: EC:2.3.1.30
xref: MetaCyc:SERINE-O-ACETTRAN-RXN
is_a: GO:0016412 ! serine O-acyltransferase activity
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0009002
name: serine-type D-Ala-D-Ala carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine." [EC:3.4.16.4]
subset: gosubset_prok
synonym: "D-alanine carboxypeptidase" BROAD [EC:3.4.16.4]
synonym: "D-alanyl carboxypeptidase activity" EXACT [EC:3.4.16.4]
synonym: "D-alanyl-D-alanine carboxypeptidase activity" EXACT [EC:3.4.16.4]
synonym: "D-alanyl-D-alanine-carboxypeptidase activity" EXACT [EC:3.4.16.4]
synonym: "D-alanyl-D-alanine-cleaving peptidase activity" EXACT [EC:3.4.16.4]
synonym: "D-alanyl-D-alanine-cleaving-peptidase activity" EXACT [EC:3.4.16.4]
synonym: "DD-carboxypeptidase" BROAD [EC:3.4.16.4]
synonym: "DD-peptidase activity" EXACT [EC:3.4.16.4]
synonym: "DD-transpeptidase activity" EXACT [EC:3.4.16.4]
xref: EC:3.4.16.4
xref: MetaCyc:3.4.16.4-RXN
is_a: GO:0004185 ! serine-type carboxypeptidase activity

[Term]
id: GO:0009003
name: signal peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor." [GOC:mah]
comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products.
is_obsolete: true
replaced_by: GO:0008233

[Term]
id: GO:0009004
name: signal peptidase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor." [EC:3.4.21.89]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "bacterial leader peptidase 1" RELATED [EC:3.4.21.89]
synonym: "bacterial leader peptidase I activity" NARROW [EC:3.4.21.89]
synonym: "Escherichia coli leader peptidase" NARROW [EC:3.4.21.89]
synonym: "eukaryotic signal peptidase" NARROW [EC:3.4.21.89]
synonym: "eukaryotic signal proteinase" NARROW [EC:3.4.21.89]
synonym: "HOSP" RELATED [EC:3.4.21.89]
synonym: "leader peptidase activity" EXACT [EC:3.4.21.89]
synonym: "leader peptidase I" RELATED [EC:3.4.21.89]
synonym: "leader peptide hydrolase activity" EXACT [EC:3.4.21.89]
synonym: "leader proteinase activity" EXACT [EC:3.4.21.89]
synonym: "phage-procoat-leader peptidase activity" NARROW [EC:3.4.21.89]
synonym: "pilin leader peptidase" NARROW [EC:3.4.21.89]
synonym: "prokaryotic leader peptidase" NARROW [EC:3.4.21.89]
synonym: "prokaryotic signal peptidase" NARROW [EC:3.4.21.89]
synonym: "prokaryotic signal proteinase" NARROW [EC:3.4.21.89]
synonym: "propeptidase activity" EXACT [EC:3.4.21.89]
synonym: "PuIO prepilin peptidase" NARROW [EC:3.4.21.89]
synonym: "signal peptide hydrolase activity" EXACT [EC:3.4.21.89]
synonym: "signal proteinase activity" EXACT [EC:3.4.21.89]
synonym: "signalase activity" EXACT [EC:3.4.21.89]
synonym: "SPase I activity" EXACT [EC:3.4.21.89]
synonym: "SPC" RELATED [EC:3.4.21.89]
xref: EC:3.4.21.89
xref: MetaCyc:3.4.21.89-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0009005
name: signal peptidase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group." [EC:3.4.23.36]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "leader peptidase II" RELATED [EC:3.4.23.36]
synonym: "lipoprotein signal peptidase activity" EXACT [EC:3.4.23.36]
synonym: "premurein leader proteinase activity" EXACT [EC:3.4.23.36]
synonym: "premurein-leader peptidase activity" NARROW [EC:3.4.23.36]
synonym: "prolipoprotein signal peptidase activity" EXACT [EC:3.4.23.36]
synonym: "prolipoprotein-signal peptidase activity" EXACT [EC:3.4.23.36]
synonym: "SPase II activity" EXACT [EC:3.4.23.36]
xref: EC:3.4.23.36
xref: MetaCyc:3.4.23.36-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0009006
name: siroheme synthase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents three different molecular functions.
synonym: "sirohaem synthase activity" EXACT []
is_obsolete: true
consider: GO:0004851
consider: GO:0019354
consider: GO:0043115
consider: GO:0051266

[Term]
id: GO:0009007
name: site-specific DNA-methyltransferase (adenine-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine." [EC:2.1.1.72]
subset: gosubset_prok
synonym: "DNA adenine methylase" BROAD []
synonym: "EcoRI methylase" NARROW [EC:2.1.1.37, EC:2.1.1.72]
synonym: "modification methylase activity" RELATED [EC:2.1.1.72]
synonym: "N-6 adenine-specific DNA methylase activity" EXACT [EC:2.1.1.72]
synonym: "restriction-modification system activity" RELATED [EC:2.1.1.72]
xref: EC:2.1.1.72
xref: MetaCyc:2.1.1.72-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0009008 ! DNA-methyltransferase activity

[Term]
id: GO:0009008
name: DNA-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to a DNA molecule." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "deoxyribonucleate methylase activity" EXACT [EC:2.1.1.-]
synonym: "deoxyribonucleate methyltransferase activity" EXACT [EC:2.1.1.-]
synonym: "deoxyribonucleic acid methylase activity" EXACT [EC:2.1.1.-]
synonym: "deoxyribonucleic acid methyltransferase activity" EXACT [EC:2.1.1.-]
synonym: "deoxyribonucleic acid modification methylase activity" RELATED [EC:2.1.1.-]
synonym: "DNA methylase" BROAD []
synonym: "DNA methyltransferase activity" EXACT []
synonym: "DNA transmethylase activity" EXACT [EC:2.1.1.-]
synonym: "Type II DNA methylase" RELATED [EC:2.1.1.37]
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0009009
name: site-specific recombinase activity
namespace: molecular_function
def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences." [GOC:elh]
comment: Consider also annotating to the molecular function term 'double-stranded DNA binding ; GO:0003690'. Note that this term is not a child of 'recombinase activity ; GO:0000150' because the latter represents activities that do not break or form phosphodiester bonds.
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0009010
name: sorbitol-6-phosphate 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.140]
subset: gosubset_prok
synonym: "D-glucitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140]
synonym: "D-sorbitol 6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140]
synonym: "D-sorbitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140]
synonym: "D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.140]
synonym: "glucitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140]
synonym: "ketosephosphate reductase activity" EXACT [EC:1.1.1.140]
synonym: "sorbitol-6-P-dehydrogenase activity" EXACT [EC:1.1.1.140]
xref: EC:1.1.1.140
xref: MetaCyc:SORB6PDEHYDROG-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0009011
name: starch synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.21]
subset: gosubset_prok
synonym: "adenosine diphosphate glucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21]
synonym: "adenosine diphosphoglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21]
synonym: "ADP-glucose starch synthase activity" EXACT [EC:2.4.1.21]
synonym: "ADP-glucose transglucosylase activity" EXACT [EC:2.4.1.21]
synonym: "ADP-glucose--starch glucosyltransferase activity" EXACT [EC:2.4.1.21]
synonym: "ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21]
synonym: "ADPG starch synthetase activity" EXACT [EC:2.4.1.21]
synonym: "ADPG-starch glucosyltransferase activity" EXACT [EC:2.4.1.21]
synonym: "ADPglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21]
synonym: "ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21]
synonym: "glycogen synthase activity" EXACT [EC:2.4.1.21]
synonym: "starch (bacterial glycogen) synthase activity" NARROW [EC:2.4.1.21]
synonym: "starch synthetase activity" EXACT [EC:2.4.1.21]
xref: EC:2.4.1.21
xref: MetaCyc:GLYCOGENSYN-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0009012
name: aminoglycoside 3''-adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + aminoglycoside = diphosphate + 3''-adenylylaminoglycoside." [EC:2.7.7.47, GOC:cb]
subset: gosubset_prok
synonym: "AAD (3'')" RELATED [EC:2.7.7.47]
synonym: "ATP:streptomycin 3''-adenylyltransferase activity" NARROW []
synonym: "streptomycin 3''-adenylyltransferase activity" NARROW []
xref: EC:2.7.7.47
xref: MetaCyc:STREPTOMYCIN-3-ADENYLYLTRANSFERASE-RXN
is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity

[Term]
id: GO:0009013
name: succinate-semialdehyde dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+." [EC:1.2.1.16]
subset: gosubset_prok
synonym: "succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.2.1.16]
synonym: "succinate-semialdehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.16]
xref: EC:1.2.1.16
xref: MetaCyc:SUCCSEMIALDDEHYDROG-RXN
xref: UM-BBD_enzymeID:e0020
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0009014
name: succinyl-diaminopimelate desuccinylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate." [EC:3.5.1.18]
subset: gosubset_prok
synonym: "N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase activity" EXACT [EC:3.5.1.18]
synonym: "N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.18]
xref: EC:3.5.1.18
xref: MetaCyc:SUCCDIAMINOPIMDESUCC-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0009015
name: N-succinylarginine dihydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-succinyl-L-arginine + 2 H2O = N2-succinyl-L-ornithine + 2 NH3 + CO." [EC:3.5.3.23]
subset: gosubset_prok
synonym: "2-N-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT [EC:3.5.3.23]
synonym: "arginine succinylhydrolase activity" EXACT []
synonym: "AruB" RELATED []
synonym: "AstB" RELATED []
synonym: "N2-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT []
synonym: "N2-succinylarginine dihydrolase activity" EXACT []
synonym: "SADH" RELATED []
synonym: "succinylarginine dihydrolase activity" EXACT []
xref: EC:3.5.3.23
xref: MetaCyc:SUCCARGDIHYDRO-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0009016
name: succinyldiaminopimelate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-L-2-amino-6-oxoheptanedioate + L-glutamate." [EC:2.6.1.17]
subset: gosubset_prok
synonym: "N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.17]
synonym: "N-succinyl-L-diaminopimelic glutamic transaminase activity" EXACT [EC:2.6.1.17]
synonym: "succinyldiaminopimelate aminotransferase activity" EXACT []
synonym: "succinyldiaminopimelate transferase activity" EXACT [EC:2.6.1.17]
xref: EC:2.6.1.17
xref: MetaCyc:SUCCINYLDIAMINOPIMTRANS-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0009017
name: succinylglutamate desuccinylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-succinyl-L-glutamate + H2O = succinate + L-glutamate." [EC:3.5.1.96]
subset: gosubset_prok
synonym: "AstE" RELATED []
synonym: "N-succinyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.96]
synonym: "N2-succinylglutamate desuccinylase activity" EXACT []
synonym: "SGDS" RELATED []
xref: EC:3.5.1.96
xref: MetaCyc:SUCCGLUDESUCC-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0009018
name: sucrose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate." [EC:2.4.1.7]
subset: gosubset_prok
synonym: "disaccharide glucosyltransferase activity" BROAD [EC:2.4.1.7]
synonym: "sucrose glucosyltransferase activity" EXACT [EC:2.4.1.7]
synonym: "sucrose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.7]
xref: EC:2.4.1.7
xref: MetaCyc:SUCROSE-PHOSPHORYLASE-RXN
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0009019
name: tRNA (guanine-N1-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine." [EC:2.1.1.31]
subset: gosubset_prok
synonym: "S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.31]
synonym: "S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.31]
synonym: "transfer ribonucleate guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31]
synonym: "tRNA guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31]
xref: EC:2.1.1.31
xref: MetaCyc:TRNA-GUANINE-N1--METHYLTRANSFERASE-RXN
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0009020
name: tRNA (guanosine-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine." [EC:2.1.1.34]
subset: gosubset_prok
synonym: "S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "S-adenosyl-L-methionine:tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "transfer ribonucleate guanosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "tRNA (Gm18) 2'-O-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "tRNA (Gm18) methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "tRNA (guanosine 2')-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "tRNA guanosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34]
synonym: "tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34]
xref: EC:2.1.1.34
xref: MetaCyc:2.1.1.34-RXN
is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity

[Term]
id: GO:0009021
name: tRNA (uracil-5-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine." [EC:2.1.1.35]
subset: gosubset_prok
synonym: "m5U-methyltransferase activity" EXACT [EC:2.1.1.35]
synonym: "M5U-methyltransferase activity" EXACT [EC:2.1.1.35]
synonym: "ribothymidyl synthase activity" BROAD [EC:2.1.1.35]
synonym: "RUMT activity" EXACT [EC:2.1.1.35]
synonym: "S-adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase activity" EXACT [EC:2.1.1.35]
synonym: "transfer RNA uracil 5-methyltransferase activity" EXACT [EC:2.1.1.35]
synonym: "transfer RNA uracil methylase activity" EXACT [EC:2.1.1.35]
synonym: "tRNA uracil 5-methyltransferase activity" EXACT [EC:2.1.1.35]
synonym: "tRNA:m(5)U54-methyltransferase activity" EXACT [EC:2.1.1.35]
synonym: "tRNA:m5U54-methyltransferase activity" EXACT [EC:2.1.1.35]
xref: EC:2.1.1.35
xref: MetaCyc:TRNA-URACIL-5--METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity

[Term]
id: GO:0009022
name: tRNA nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate." [EC:2.7.7.56]
comment: Note that, although the enzyme to which this term refers is also known as 'ribonuclease PH', and degrades tRNA in the 3'-5' direction in vivo, the term does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis.
subset: gosubset_prok
synonym: "phosphate-dependent exonuclease activity" RELATED [EC:2.7.7.56]
synonym: "ribonuclease PH activity" EXACT [EC:2.7.7.56]
synonym: "RNase PH activity" EXACT [EC:2.7.7.56]
synonym: "tRNA:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.56]
xref: EC:2.7.7.56
xref: MetaCyc:TRNA-NUCLEOTIDYLTRANSFERASE-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0009023
name: tRNA sulfurtransferase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-cysteine + activated-tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4, GOC:go_curators]
synonym: "tRNA sulphurtransferase activity" EXACT []
is_obsolete: true
replaced_by: GO:0034227
consider: GO:0016783

[Term]
id: GO:0009024
name: tagatose-6-phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate." [EC:2.7.1.144]
subset: gosubset_prok
synonym: "ATP:D-tagatose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.144]
synonym: "phosphotagatokinase activity" EXACT [EC:2.7.1.144]
xref: EC:2.7.1.144
xref: MetaCyc:TAGAKIN-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0009025
name: tagatose-bisphosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.40]
subset: gosubset_prok
synonym: "AgaY" RELATED []
synonym: "AgaZ" RELATED []
synonym: "D-tagatose-1,6-bisphosphate aldolase activity" EXACT [EC:4.1.2.40]
synonym: "D-tagatose-1,6-bisphosphate D-glyceraldehyde 3-phosphate-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.40]
synonym: "D-tagatose-1,6-bisphosphate triosephosphate lyase activity" EXACT []
synonym: "D-tagatose-1xxx,6-bisphosphate triosephosphate lyase activity" EXACT [EC:4.1.2.40]
synonym: "KbaY" RELATED []
synonym: "tagatose 1,6-diphosphate aldolase activity" EXACT [EC:4.1.2.40]
synonym: "tagatose-1,6-bisphosphate aldolase 1" EXACT []
xref: EC:4.1.2.40
xref: MetaCyc:TAGAALDOL-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0009026
name: tagaturonate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-altronate + NAD+ = D-tagaturonate + NADH + H+." [EC:1.1.1.58]
subset: gosubset_prok
synonym: "altronate dehydrogenase activity" EXACT [EC:1.1.1.58]
synonym: "altronate oxidoreductase activity" EXACT [EC:1.1.1.58]
synonym: "altronic oxidoreductase activity" EXACT [EC:1.1.1.58]
synonym: "D-altronate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.58]
synonym: "D-tagaturonate reductase activity" EXACT [EC:1.1.1.58]
synonym: "tagaturonate dehydrogenase activity" EXACT [EC:1.1.1.58]
synonym: "TagUAR" RELATED [EC:1.1.1.58]
xref: EC:1.1.1.58
xref: MetaCyc:ALTRO-OXIDOREDUCT-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0009027
name: tartrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+." [EC:1.1.1.93]
subset: gosubset_prok
synonym: "mesotartrate dehydrogenase activity" EXACT [EC:1.1.1.93]
synonym: "tartrate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.93]
xref: EC:1.1.1.93
xref: MetaCyc:TARTRATE-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0009028
name: tartronate-semialdehyde synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glyoxylate = tartronate semialdehyde + CO2." [EC:4.1.1.47]
subset: gosubset_prok
synonym: "glyoxalate carboligase activity" EXACT [EC:4.1.1.47]
synonym: "glyoxylate carbo-ligase activity" EXACT [EC:4.1.1.47]
synonym: "glyoxylate carboligase activity" EXACT [EC:4.1.1.47]
synonym: "glyoxylate carboxy-lyase (dimerizing)" EXACT [EC:4.1.1.47]
synonym: "glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming)" EXACT [EC:4.1.1.47]
synonym: "glyoxylic carbo-ligase activity" EXACT [EC:4.1.1.47]
synonym: "hydroxymalonic semialdehyde carboxylase activity" EXACT [EC:4.1.1.47]
synonym: "tartronate semialdehyde carboxylase activity" EXACT [EC:4.1.1.47]
synonym: "tartronic semialdehyde carboxylase activity" EXACT [EC:4.1.1.47]
xref: EC:4.1.1.47
xref: MetaCyc:GLYOCARBOLIG-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0009029
name: tetraacyldisaccharide 4'-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl beta-phosphate = ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate." [EC:2.7.1.130]
subset: gosubset_prok
synonym: "ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-beta-D-1,6-glucosaminyl-beta-phosphate 4'-O-phosphotransferase activity" EXACT [EC:2.7.1.130]
synonym: "lipid-A 4'-kinase activity" RELATED [EC:2.7.1.130]
xref: EC:2.7.1.130
xref: MetaCyc:TETRAACYLDISACC4KIN-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0009030
name: thiamin phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thiamin phosphate = ADP + thiamin diphosphate." [EC:2.7.4.16]
subset: gosubset_prok
synonym: "ATP:thiamine-phosphate phosphotransferase activity" EXACT [EC:2.7.4.16]
synonym: "thiamin monophosphatase activity" EXACT [EC:2.7.4.16]
synonym: "thiamin monophosphokinase activity" EXACT [EC:2.7.4.16]
synonym: "thiamin-monophosphate kinase activity" EXACT [EC:2.7.4.16]
synonym: "thiamin-phosphate kinase activity" EXACT []
synonym: "thiamine-monophosphate kinase activity" EXACT [EC:2.7.4.16]
synonym: "thiamine-phosphate kinase activity" EXACT []
xref: EC:2.7.4.16
xref: MetaCyc:THI-P-KIN-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0009032
name: thymidine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate." [EC:2.4.2.4]
subset: gosubset_prok
synonym: "animal growth regulators, blood platelet-derived endothelial cell growth factors" RELATED [EC:2.4.2.4]
synonym: "blood platelet-derived endothelial cell growth factor" RELATED [EC:2.4.2.4]
synonym: "deoxythymidine phosphorylase activity" EXACT [EC:2.4.2.4]
synonym: "gliostatins" RELATED [EC:2.4.2.4]
synonym: "pyrimidine deoxynucleoside phosphorylase activity" EXACT [EC:2.4.2.4]
synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.4]
synonym: "thymidine-orthophosphate deoxyribosyltransferase activity" EXACT [EC:2.4.2.4]
synonym: "thymidine:phosphate deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.4]
synonym: "thymidine:phosphate deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.4]
xref: EC:2.4.2.4
xref: MetaCyc:THYM-PHOSPH-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0009033
name: trimethylamine-N-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O." [EC:1.6.6.9]
subset: gosubset_prok
synonym: "NADH:trimethylamine-N-oxide oxidoreductase" EXACT [EC:1.6.6.9]
synonym: "trimethylamine N-oxide reductase" EXACT [EC:1.6.6.9]
synonym: "trimethylamine oxidase activity" EXACT [EC:1.6.6.9]
synonym: "trimethylamine oxide reductase" EXACT [EC:1.6.6.9]
xref: EC:1.6.6.9
xref: MetaCyc:TMAOREDUCT-RXN
is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor

[Term]
id: GO:0009034
name: tryptophanase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + H2O = indole + pyruvate + NH3." [EC:4.1.99.1]
comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step.
subset: gosubset_prok
synonym: "L-tryptophan indole-lyase (deaminating) activity" EXACT [EC:4.1.99.1]
synonym: "L-tryptophan indole-lyase (deaminating; pyruvate forming) activity" EXACT [EC:4.1.99.1]
synonym: "L-tryptophan indole-lyase activity" EXACT [EC:4.1.99.1]
synonym: "L-tryptophanase activity" EXACT [EC:4.1.99.1]
synonym: "TNase activity" EXACT [EC:4.1.99.1]
synonym: "tryptophan catabolic process, using tryptophanase" RELATED [EC:4.1.99.1]
synonym: "tryptophan catabolism, using tryptophanase" RELATED [EC:4.1.99.1]
xref: EC:4.1.99.1
xref: MetaCyc:TRYPDEG-PWY
xref: MetaCyc:TRYPTOPHAN-RXN
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0009035
name: Type I site-specific deoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA." [EC:3.1.21.3, PMID:15788748]
subset: gosubset_prok
synonym: "adenosine triphosphate-dependent deoxyribonuclease activity" EXACT [EC:3.1.21.3]
synonym: "ATP-dependent DNase activity" EXACT [EC:3.1.21.3]
synonym: "deoxyribonuclease (adenosine triphosphate-hydrolyzing)" EXACT [EC:3.1.21.3]
synonym: "deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)" EXACT [EC:3.1.21.3]
synonym: "Type I restriction enzyme activity" EXACT []
synonym: "type I site-specific deoxyribonuclease activity" EXACT [EC:3.1.21.3]
xref: EC:3.1.21.3
xref: MetaCyc:3.1.21.3-RXN
is_a: GO:0015666 ! restriction endodeoxyribonuclease activity
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0009036
name: Type II site-specific deoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site." [EC:3.1.21.4, PMID:12654995]
subset: gosubset_prok
synonym: "Type II restriction enzyme activity" EXACT []
xref: EC:3.1.21.4
xref: MetaCyc:3.1.21.4-RXN
is_a: GO:0015666 ! restriction endodeoxyribonuclease activity
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0009037
name: tyrosine-based site-specific recombinase activity
namespace: molecular_function
def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site." [GOC:elh, PMID:11090626]
subset: gosubset_prok
synonym: "site-specific tyrosine recombinase activity" EXACT []
synonym: "tyrosine recombinase" BROAD []
is_a: GO:0008907 ! integrase activity
is_a: GO:0009009 ! site-specific recombinase activity

[Term]
id: GO:0009038
name: undecaprenol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate." [EC:2.7.1.66]
subset: gosubset_prok
synonym: "ATP:undecaprenol phosphotransferase activity" EXACT [EC:2.7.1.66]
synonym: "C55-isoprenoid alcohol kinase activity" EXACT [EC:2.7.1.66]
synonym: "C55-isoprenoid alcohol phosphokinase activity" EXACT [EC:2.7.1.66]
synonym: "C55-isoprenyl alcohol phosphokinase activity" EXACT [EC:2.7.1.66]
synonym: "isoprenoid alcohol kinase (phosphorylating)" EXACT [EC:2.7.1.66]
synonym: "isoprenoid alcohol kinase activity" EXACT [EC:2.7.1.66]
synonym: "isoprenoid alcohol phosphokinase activity" EXACT [EC:2.7.1.66]
synonym: "isoprenoid-alcohol kinase activity" BROAD [EC:2.7.1.66]
synonym: "polyisoprenol kinase activity" EXACT [EC:2.7.1.66]
xref: EC:2.7.1.66
xref: MetaCyc:UNDECAPRENOL-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0009039
name: urease activity
namespace: molecular_function
def: "Catalysis of the reaction: urea + H2O = CO2 + 2 NH3." [EC:3.5.1.5]
subset: gosubset_prok
synonym: "urea amidohydrolase activity" EXACT [EC:3.5.1.5]
xref: EC:3.5.1.5
xref: MetaCyc:UREASE-RXN
xref: UM-BBD_enzymeID:e0170
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0009040
name: ureidoglycolate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-ureidoglycolate + NADP+ = oxalureate + NADPH + H+." [EC:1.1.1.154]
subset: gosubset_prok
synonym: "(S)-ureidoglycolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.154]
xref: EC:1.1.1.154
xref: MetaCyc:R165-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0009041
name: uridylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP." [GOC:go_curators]
subset: gosubset_prok
xref: EC:2.7.4.-
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019201 ! nucleotide kinase activity

[Term]
id: GO:0009042
name: valine-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine." [EC:2.6.1.66]
subset: gosubset_prok
synonym: "alanine--valine transaminase activity" EXACT [EC:2.6.1.66]
synonym: "alanine-oxoisovalerate aminotransferase activity" EXACT [EC:2.6.1.66]
synonym: "L-valine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.66]
synonym: "transaminase C activity" NARROW [EC:2.6.1.66]
synonym: "valine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.66]
synonym: "valine-pyruvate aminotransferase activity" EXACT []
xref: EC:2.6.1.66
xref: MetaCyc:VALINE-PYRUVATE-AMINOTRANSFER-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0009044
name: xylan 1,4-beta-xylosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of 1,4-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini." [EC:3.2.1.37]
subset: gosubset_prok
synonym: "1,4-beta-D-xylan xylohydrolase activity" EXACT [EC:3.2.1.37]
synonym: "beta-D-xylopyranosidase activity" EXACT [EC:3.2.1.37]
synonym: "beta-xylosidase activity" EXACT [EC:3.2.1.37]
synonym: "exo-1,4-beta-D-xylosidase activity" EXACT [EC:3.2.1.37]
synonym: "exo-1,4-beta-xylosidase activity" EXACT [EC:3.2.1.37]
synonym: "exo-1,4-xylosidase activity" EXACT [EC:3.2.1.37]
synonym: "xylobiase activity" EXACT [EC:3.2.1.37]
xref: EC:3.2.1.37
xref: MetaCyc:3.2.1.37-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0009045
name: xylose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylose = D-xylulose." [EC:5.3.1.5]
subset: gosubset_prok
synonym: "D-xylose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.5]
synonym: "D-xylose isomerase activity" EXACT [EC:5.3.1.5]
synonym: "D-xylose ketoisomerase activity" EXACT [EC:5.3.1.5]
synonym: "D-xylose ketol-isomerase activity" EXACT [EC:5.3.1.5]
xref: EC:5.3.1.5
xref: MetaCyc:XYLISOM-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0009046
name: zinc D-Ala-D-Ala carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine." [EC:3.4.17.14]
synonym: "D-alanyl-D-alanine hydrolase activity" EXACT [EC:3.4.17.14]
synonym: "D-alanyl-D-alanine-cleaving carboxypeptidase activity" EXACT [EC:3.4.17.14]
synonym: "DD-carboxypeptidase" BROAD [EC:3.4.17.14]
synonym: "DD-carboxypeptidase-transpeptidase activity" EXACT [EC:3.4.17.14]
synonym: "G enzyme" RELATED [EC:3.4.17.14]
synonym: "Zn(2+) G peptidase activity" RELATED [EC:3.4.17.14]
synonym: "Zn2+ G peptidase activity" EXACT [EC:3.4.17.14]
xref: EC:3.4.17.14
xref: MetaCyc:3.4.17.14-RXN
is_a: GO:0004181 ! metallocarboxypeptidase activity

[Term]
id: GO:0009047
name: dosage compensation, by hyperactivation of X chromosome
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577]
is_a: GO:0007549 ! dosage compensation

[Term]
id: GO:0009048
name: dosage compensation, by inactivation of X chromosome
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex." [GOC:jl, ISBN:0140512888, PMID:11498577]
synonym: "Barr body formation" RELATED []
synonym: "chromosome inactivation" BROAD []
synonym: "X chromosome inactivation" EXACT []
xref: Wikipedia:X-inactivation
is_a: GO:0007549 ! dosage compensation

[Term]
id: GO:0009049
name: aspartic-type signal peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism." [GOC:mah]
comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products.
subset: gosubset_prok
xref: EC:3.4.23.-
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0009050
name: glycopeptide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycopeptides, any compound in which carbohydrate is covalently attached to an oligopeptide composed of residues of L and/or D-amino acids. The term usually denotes a product of proteolytic degradation of a glycoprotein but includes glycated peptide." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycopeptide breakdown" EXACT []
synonym: "glycopeptide catabolism" EXACT []
synonym: "glycopeptide degradation" EXACT []
is_a: GO:0006516 ! glycoprotein catabolic process
is_a: GO:0043171 ! peptide catabolic process

[Term]
id: GO:0009051
name: pentose-phosphate shunt, oxidative branch
namespace: biological_process
def: "The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:OXIDATIVEPENT-PWY]
subset: gosubset_prok
synonym: "oxidative branch, pentose pathway" EXACT []
synonym: "oxidative pentose phosphate pathway" EXACT []
synonym: "pentose phosphate pathway, oxidative branch" EXACT []
synonym: "pentose phosphate shunt, oxidative branch" EXACT []
synonym: "pentose-phosphate pathway, oxidative branch" EXACT []
xref: MetaCyc:OXIDATIVEPENT-PWY
is_a: GO:0019321 ! pentose metabolic process
relationship: part_of GO:0006098 ! pentose-phosphate shunt

[Term]
id: GO:0009052
name: pentose-phosphate shunt, non-oxidative branch
namespace: biological_process
def: "The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:NONOXIPENT-PWY]
subset: gosubset_prok
synonym: "pentose phosphate pathway, non-oxidative branch" EXACT []
synonym: "pentose phosphate shunt, non-oxidative branch" EXACT []
synonym: "pentose-phosphate pathway, non-oxidative branch" EXACT []
xref: MetaCyc:NONOXIPENT-PWY
xref: MetaCyc:P21-PWY
is_a: GO:0019321 ! pentose metabolic process
relationship: part_of GO:0006098 ! pentose-phosphate shunt

[Term]
id: GO:0009055
name: electron carrier activity
namespace: molecular_function
alt_id: GO:0009053
alt_id: GO:0009054
def: "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: gosubset_prok
synonym: "2Fe-2S electron transfer carrier" NARROW []
synonym: "3Fe-4S/4Fe-4S electron transfer carrier" NARROW []
synonym: "adrenodoxin-type ferredoxin" NARROW []
synonym: "amicyanin" NARROW []
synonym: "azurin" NARROW []
synonym: "bacterial-type ferredoxin" NARROW []
synonym: "chloroplast-type ferredoxin" NARROW []
synonym: "copper electron carrier" NARROW []
synonym: "dicluster bacterial-type ferredoxin" NARROW []
synonym: "electron acceptor activity" NARROW []
synonym: "electron carrier, chlorophyll electron transport system" RELATED []
synonym: "electron donor activity" NARROW []
synonym: "electron transfer flavoprotein" NARROW []
synonym: "electron transfer flavoprotein, group I" NARROW []
synonym: "electron transfer flavoprotein, group II" NARROW []
synonym: "electron transporter activity" EXACT []
synonym: "high-potential iron-sulfur carrier" NARROW []
synonym: "iron-sulfur electron transfer carrier" NARROW []
synonym: "monocluster bacterial-type ferredoxin" NARROW []
synonym: "mononuclear iron electron carrier" NARROW []
synonym: "polyferredoxin" NARROW []
synonym: "redox-active disulfide bond electron carrier" NARROW []
synonym: "rubredoxin" NARROW []
synonym: "small blue copper electron carrier" NARROW []
synonym: "thioredoxin-like 2Fe-2S ferredoxin" NARROW []
xref: Reactome:20046 "electron carrier activity"
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0009056
name: catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684]
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: gosubset_prok
synonym: "breakdown" EXACT []
synonym: "catabolism" EXACT []
synonym: "degradation" EXACT []
xref: Wikipedia:Catabolism
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0009057
name: macromolecule catabolic process
namespace: biological_process
alt_id: GO:0043285
def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [ChEBI:33694, GOC:mah]
subset: gosubset_prok
synonym: "biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "macromolecule breakdown" EXACT []
synonym: "macromolecule catabolism" EXACT []
synonym: "macromolecule degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0009058
name: biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684]
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: gosubset_prok
synonym: "anabolism" EXACT []
synonym: "biosynthesis" EXACT []
synonym: "formation" EXACT []
synonym: "synthesis" EXACT []
xref: Wikipedia:Anabolism
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0009059
name: macromolecule biosynthetic process
namespace: biological_process
alt_id: GO:0043284
def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [ChEBI:33694, GOC:mah]
subset: gosubset_prok
synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "macromolecule anabolism" EXACT []
synonym: "macromolecule biosynthesis" EXACT []
synonym: "macromolecule formation" EXACT []
synonym: "macromolecule synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0009060
name: aerobic respiration
namespace: biological_process
def: "The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:jl, ISBN:0140513590]
subset: gosubset_prok
xref: MetaCyc:PWY-3781
xref: Wikipedia:Cellular_respiration#Aerobic_respiration
is_a: GO:0045333 ! cellular respiration

[Term]
id: GO:0009061
name: anaerobic respiration
namespace: biological_process
def: "The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor." [GOC:jl, ISBN:0140513590]
subset: gosubset_prok
xref: MetaCyc:ANARESP1-PWY
xref: Wikipedia:Anaerobic_respiration
xref: Wikipedia:Cellular_respiration#Anaerobic_respiration
is_a: GO:0045333 ! cellular respiration

[Term]
id: GO:0009062
name: fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators]
subset: gosubset_prok
synonym: "fatty acid breakdown" EXACT []
synonym: "fatty acid catabolism" EXACT []
synonym: "fatty acid degradation" EXACT []
xref: Wikipedia:Fatty_acid_degradation
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0044242 ! cellular lipid catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0009063
name: cellular amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai]
subset: gosubset_prok
synonym: "cellular amino acid breakdown" EXACT []
synonym: "cellular amino acid catabolism" EXACT []
synonym: "cellular amino acid degradation" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0009310 ! amine catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0009064
name: glutamine family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]
subset: gosubset_prok
synonym: "glutamine family amino acid metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0009065
name: glutamine family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]
subset: gosubset_prok
synonym: "glutamine family amino acid breakdown" EXACT []
synonym: "glutamine family amino acid catabolism" EXACT []
synonym: "glutamine family amino acid degradation" EXACT []
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0009064 ! glutamine family amino acid metabolic process

[Term]
id: GO:0009066
name: aspartate family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]
subset: gosubset_prok
synonym: "aspartate family amino acid metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0009067
name: aspartate family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]
subset: gosubset_prok
synonym: "aspartate family amino acid anabolism" EXACT []
synonym: "aspartate family amino acid biosynthesis" EXACT []
synonym: "aspartate family amino acid formation" EXACT []
synonym: "aspartate family amino acid synthesis" EXACT []
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0009066 ! aspartate family amino acid metabolic process

[Term]
id: GO:0009068
name: aspartate family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai]
subset: gosubset_prok
synonym: "aspartate family amino acid breakdown" EXACT []
synonym: "aspartate family amino acid catabolism" EXACT []
synonym: "aspartate family amino acid degradation" EXACT []
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0009066 ! aspartate family amino acid metabolic process

[Term]
id: GO:0009069
name: serine family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]
subset: gosubset_prok
synonym: "serine family amino acid metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0009070
name: serine family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]
subset: gosubset_prok
synonym: "serine family amino acid anabolism" EXACT []
synonym: "serine family amino acid biosynthesis" EXACT []
synonym: "serine family amino acid formation" EXACT []
synonym: "serine family amino acid synthesis" EXACT []
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0009071
name: serine family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai]
subset: gosubset_prok
synonym: "serine family amino acid breakdown" EXACT []
synonym: "serine family amino acid catabolism" EXACT []
synonym: "serine family amino acid degradation" EXACT []
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0009072
name: aromatic amino acid family metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]
subset: gosubset_prok
synonym: "aromatic amino acid family metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0006725 ! cellular aromatic compound metabolic process

[Term]
id: GO:0009073
name: aromatic amino acid family biosynthetic process
namespace: biological_process
alt_id: GO:0016089
def: "The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]
subset: gosubset_prok
synonym: "aromatic amino acid family anabolism" EXACT []
synonym: "aromatic amino acid family biosynthesis" EXACT []
synonym: "aromatic amino acid family biosynthetic process, shikimate pathway" RELATED []
synonym: "aromatic amino acid family formation" EXACT []
synonym: "aromatic amino acid family synthesis" EXACT []
xref: MetaCyc:COMPLETE-ARO-PWY
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0009072 ! aromatic amino acid family metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0046417 ! chorismate metabolic process

[Term]
id: GO:0009074
name: aromatic amino acid family catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators]
subset: gosubset_prok
synonym: "aromatic amino acid family breakdown" EXACT []
synonym: "aromatic amino acid family catabolism" EXACT []
synonym: "aromatic amino acid family degradation" EXACT []
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0009072 ! aromatic amino acid family metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process

[Term]
id: GO:0009075
name: histidine family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids of the histidine family." [GOC:ai]
subset: gosubset_prok
synonym: "histidine family amino acid metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0009076
name: histidine family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids of the histidine family." [GOC:ai]
subset: gosubset_prok
synonym: "histidine family amino acid anabolism" EXACT []
synonym: "histidine family amino acid biosynthesis" EXACT []
synonym: "histidine family amino acid formation" EXACT []
synonym: "histidine family amino acid synthesis" EXACT []
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0009075 ! histidine family amino acid metabolic process

[Term]
id: GO:0009077
name: histidine family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the histidine family." [GOC:ai]
subset: gosubset_prok
synonym: "histidine family amino acid breakdown" EXACT []
synonym: "histidine family amino acid catabolism" EXACT []
synonym: "histidine family amino acid degradation" EXACT []
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0009075 ! histidine family amino acid metabolic process

[Term]
id: GO:0009078
name: pyruvate family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl]
subset: gosubset_prok
synonym: "pyruvate family amino acid metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0009079
name: pyruvate family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl]
subset: gosubset_prok
synonym: "pyruvate family amino acid anabolism" EXACT []
synonym: "pyruvate family amino acid biosynthesis" EXACT []
synonym: "pyruvate family amino acid formation" EXACT []
synonym: "pyruvate family amino acid synthesis" EXACT []
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0009078 ! pyruvate family amino acid metabolic process

[Term]
id: GO:0009080
name: pyruvate family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl]
subset: gosubset_prok
synonym: "pyruvate family amino acid breakdown" EXACT []
synonym: "pyruvate family amino acid catabolism" EXACT []
synonym: "pyruvate family amino acid degradation" EXACT []
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0009078 ! pyruvate family amino acid metabolic process

[Term]
id: GO:0009081
name: branched chain family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]
subset: gosubset_prok
synonym: "branched chain family amino acid metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0009082
name: branched chain family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]
subset: gosubset_prok
synonym: "branched chain family amino acid anabolism" EXACT []
synonym: "branched chain family amino acid biosynthesis" EXACT []
synonym: "branched chain family amino acid formation" EXACT []
synonym: "branched chain family amino acid synthesis" EXACT []
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0009081 ! branched chain family amino acid metabolic process

[Term]
id: GO:0009083
name: branched chain family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai]
subset: gosubset_prok
synonym: "branched chain family amino acid breakdown" EXACT []
synonym: "branched chain family amino acid catabolism" EXACT []
synonym: "branched chain family amino acid degradation" EXACT []
xref: Reactome:448562 "Branched-chain amino acid catabolism"
xref: Reactome:469691 "Branched-chain amino acid catabolism"
xref: Reactome:487403 "Branched-chain amino acid catabolism"
xref: Reactome:507355 "Branched-chain amino acid catabolism"
xref: Reactome:517365 "Branched-chain amino acid catabolism"
xref: Reactome:526243 "Branched-chain amino acid catabolism"
xref: Reactome:531120 "Branched-chain amino acid catabolism"
xref: Reactome:536607 "Branched-chain amino acid catabolism"
xref: Reactome:542202 "Branched-chain amino acid catabolism"
xref: Reactome:547671 "Branched-chain amino acid catabolism"
xref: Reactome:552158 "Branched-chain amino acid catabolism"
xref: Reactome:557746 "Branched-chain amino acid catabolism"
xref: Reactome:568363 "Branched-chain amino acid catabolism"
xref: Reactome:581565 "Branched-chain amino acid catabolism"
xref: Reactome:592461 "Branched-chain amino acid catabolism"
xref: Reactome:595328 "Branched-chain amino acid catabolism"
xref: Reactome:597346 "Branched-chain amino acid catabolism"
xref: Reactome:598192 "Branched-chain amino acid catabolism"
xref: Reactome:599707 "Branched-chain amino acid catabolism"
xref: Reactome:600628 "Branched-chain amino acid catabolism"
xref: Reactome:602445 "Branched-chain amino acid catabolism"
xref: Reactome:70895 "Branched-chain amino acid catabolism"
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0009081 ! branched chain family amino acid metabolic process

[Term]
id: GO:0009084
name: glutamine family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai]
subset: gosubset_prok
synonym: "glutamine family amino acid anabolism" EXACT []
synonym: "glutamine family amino acid biosynthesis" EXACT []
synonym: "glutamine family amino acid formation" EXACT []
synonym: "glutamine family amino acid synthesis" EXACT []
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0009064 ! glutamine family amino acid metabolic process

[Term]
id: GO:0009085
name: lysine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "lysine anabolism" EXACT []
synonym: "lysine biosynthesis" EXACT []
synonym: "lysine formation" EXACT []
synonym: "lysine synthesis" EXACT []
xref: MetaCyc:PWY-5097
is_a: GO:0006553 ! lysine metabolic process
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process

[Term]
id: GO:0009086
name: methionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "methionine anabolism" EXACT []
synonym: "methionine biosynthesis" EXACT []
synonym: "methionine formation" EXACT []
synonym: "methionine synthesis" EXACT []
is_a: GO:0000097 ! sulfur amino acid biosynthetic process
is_a: GO:0006555 ! methionine metabolic process
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process

[Term]
id: GO:0009087
name: methionine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "methionine breakdown" EXACT []
synonym: "methionine catabolism" EXACT []
synonym: "methionine degradation" EXACT []
xref: UM-BBD_pathwayID:met
is_a: GO:0000098 ! sulfur amino acid catabolic process
is_a: GO:0006555 ! methionine metabolic process
is_a: GO:0009068 ! aspartate family amino acid catabolic process

[Term]
id: GO:0009088
name: threonine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "threonine anabolism" EXACT []
synonym: "threonine biosynthesis" EXACT []
synonym: "threonine formation" EXACT []
synonym: "threonine synthesis" EXACT []
xref: MetaCyc:HOMOSER-THRESYN-PWY
xref: MetaCyc:THRESYN-PWY
is_a: GO:0006566 ! threonine metabolic process
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process

[Term]
id: GO:0009089
name: lysine biosynthetic process via diaminopimelate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators]
subset: gosubset_prok
synonym: "diaminopimelate pathway" EXACT []
synonym: "diaminopimelic acid pathway" EXACT []
synonym: "lysine anabolism via diaminopimelate" EXACT []
synonym: "lysine biosynthesis via diaminopimelic acid" EXACT []
synonym: "lysine biosynthetic process via diaminopimelic acid" EXACT []
synonym: "lysine formation via diaminopimelate" EXACT []
synonym: "lysine synthesis via diaminopimelate" EXACT []
is_a: GO:0009085 ! lysine biosynthetic process
is_a: GO:0046451 ! diaminopimelate metabolic process

[Term]
id: GO:0009090
name: homoserine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "homoserine anabolism" EXACT []
synonym: "homoserine biosynthesis" EXACT []
synonym: "homoserine formation" EXACT []
synonym: "homoserine synthesis" EXACT []
xref: MetaCyc:HOMOSERSYN-PWY
is_a: GO:0009070 ! serine family amino acid biosynthetic process
is_a: GO:0009092 ! homoserine metabolic process

[Term]
id: GO:0009091
name: homoserine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "homoserine breakdown" EXACT []
synonym: "homoserine catabolism" EXACT []
synonym: "homoserine degradation" EXACT []
xref: MetaCyc:HOMOCYSDEGR-PWY
is_a: GO:0009071 ! serine family amino acid catabolic process
is_a: GO:0009092 ! homoserine metabolic process

[Term]
id: GO:0009092
name: homoserine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "homoserine metabolism" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0009093
name: cysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "cysteine breakdown" EXACT []
synonym: "cysteine catabolism" EXACT []
synonym: "cysteine degradation" EXACT []
xref: Wikipedia:Cysteine
is_a: GO:0000098 ! sulfur amino acid catabolic process
is_a: GO:0006534 ! cysteine metabolic process
is_a: GO:0009071 ! serine family amino acid catabolic process

[Term]
id: GO:0009094
name: L-phenylalanine biosynthetic process
namespace: biological_process
alt_id: GO:0019274
alt_id: GO:0019275
def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [ChEBI:17295, GOC:go_curators, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-phenylalanine anabolism" EXACT []
synonym: "L-phenylalanine biosynthesis" EXACT []
synonym: "L-phenylalanine formation" EXACT []
synonym: "L-phenylalanine synthesis" EXACT []
synonym: "phenylalanine biosynthesis" BROAD []
synonym: "phenylalanine biosynthetic process" BROAD []
synonym: "phenylalanine biosynthetic process, prephenate pathway" RELATED []
synonym: "phenylalanine biosynthetic process, shikimate pathway" RELATED []
is_a: GO:0006558 ! L-phenylalanine metabolic process
is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway

[Term]
id: GO:0009095
name: aromatic amino acid family biosynthetic process, prephenate pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate." [GOC:mah, ISBN:0471331309 "Biochemical Pathways"]
subset: gosubset_prok
synonym: "aromatic amino acid family anabolism, prephenate pathway" EXACT []
synonym: "aromatic amino acid family formation, prephenate pathway" EXACT []
synonym: "aromatic amino acid family synthesis, prephenate pathway" EXACT []
is_a: GO:0009073 ! aromatic amino acid family biosynthetic process

[Term]
id: GO:0009097
name: isoleucine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "isoleucine anabolism" EXACT []
synonym: "isoleucine biosynthesis" EXACT []
synonym: "isoleucine formation" EXACT []
synonym: "isoleucine synthesis" EXACT []
xref: MetaCyc:ILEUSYN-PWY
is_a: GO:0006549 ! isoleucine metabolic process
is_a: GO:0009082 ! branched chain family amino acid biosynthetic process

[Term]
id: GO:0009098
name: leucine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "leucine anabolism" EXACT []
synonym: "leucine biosynthesis" EXACT []
synonym: "leucine formation" EXACT []
synonym: "leucine synthesis" EXACT []
xref: MetaCyc:LEUSYN-PWY
is_a: GO:0006551 ! leucine metabolic process
is_a: GO:0009082 ! branched chain family amino acid biosynthetic process

[Term]
id: GO:0009099
name: valine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "valine anabolism" EXACT []
synonym: "valine biosynthesis" EXACT []
synonym: "valine formation" EXACT []
synonym: "valine synthesis" EXACT []
xref: MetaCyc:VALSYN-PWY
is_a: GO:0006573 ! valine metabolic process
is_a: GO:0009082 ! branched chain family amino acid biosynthetic process

[Term]
id: GO:0009100
name: glycoprotein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycoprotein metabolism" EXACT []
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0009101
name: glycoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycoprotein anabolism" EXACT []
synonym: "glycoprotein biosynthesis" EXACT []
synonym: "glycoprotein formation" EXACT []
synonym: "glycoprotein synthesis" EXACT []
xref: Reactome:162699 "Synthesis of dolichol-phosphate mannose"
xref: Reactome:542502 "Synthesis of dolichol-phosphate mannose"
xref: Reactome:568654 "Synthesis of dolichol-phosphate mannose"
xref: Reactome:592766 "Synthesis of dolichol-phosphate mannose"
is_a: GO:0009100 ! glycoprotein metabolic process
is_a: GO:0034645 ! cellular macromolecule biosynthetic process

[Term]
id: GO:0009102
name: biotin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "biotin anabolism" EXACT []
synonym: "biotin biosynthesis" EXACT []
synonym: "biotin formation" EXACT []
synonym: "biotin synthesis" EXACT []
synonym: "vitamin B7 biosynthesis" EXACT []
synonym: "vitamin B7 biosynthetic process" EXACT []
synonym: "vitamin H biosynthesis" EXACT []
synonym: "vitamin H biosynthetic process" EXACT []
xref: MetaCyc:BIOTIN-SYNTHESIS-PWY
xref: MetaCyc:PWY-3701
is_a: GO:0006768 ! biotin metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0009103
name: lipopolysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai]
subset: gosubset_prok
synonym: "lipopolysaccharide anabolism" EXACT []
synonym: "lipopolysaccharide biosynthesis" EXACT []
synonym: "lipopolysaccharide formation" EXACT []
synonym: "lipopolysaccharide synthesis" EXACT []
synonym: "LPS biosynthetic process" EXACT []
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0008653 ! lipopolysaccharide metabolic process
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process

[Term]
id: GO:0009104
name: lipopolysaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai]
subset: gosubset_prok
synonym: "lipopolysaccharide breakdown" EXACT []
synonym: "lipopolysaccharide catabolism" EXACT []
synonym: "lipopolysaccharide degradation" EXACT []
synonym: "LPS catabolic process" EXACT []
is_a: GO:0008653 ! lipopolysaccharide metabolic process
is_a: GO:0044242 ! cellular lipid catabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process

[Term]
id: GO:0009105
name: lipoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipoic acid, 1,2-dithiolane-3-pentanoic acid, a coenzyme involved in oxidative decarboxylation of keto acids." [GOC:ai, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "lipoic acid anabolism" EXACT []
synonym: "lipoic acid biosynthesis" EXACT []
synonym: "lipoic acid formation" EXACT []
synonym: "lipoic acid synthesis" EXACT []
is_a: GO:0000273 ! lipoic acid metabolic process
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0009106
name: lipoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "lipoate metabolism" EXACT []
is_a: GO:0000273 ! lipoic acid metabolic process

[Term]
id: GO:0009107
name: lipoate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "lipoate anabolism" EXACT []
synonym: "lipoate biosynthesis" EXACT []
synonym: "lipoate formation" EXACT []
synonym: "lipoate synthesis" EXACT []
is_a: GO:0009105 ! lipoic acid biosynthetic process
is_a: GO:0009106 ! lipoate metabolic process

[Term]
id: GO:0009108
name: coenzyme biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
subset: gosubset_prok
synonym: "coenzyme anabolism" EXACT []
synonym: "coenzyme and prosthetic group biosynthesis" BROAD []
synonym: "coenzyme and prosthetic group biosynthetic process" BROAD []
synonym: "coenzyme biosynthesis" EXACT []
synonym: "coenzyme formation" EXACT []
synonym: "coenzyme synthesis" EXACT []
xref: Reactome:196783 "Coenzyme A biosynthesis"
xref: Reactome:448762 "Coenzyme A biosynthesis"
xref: Reactome:469877 "Coenzyme A biosynthesis"
xref: Reactome:487794 "Coenzyme A biosynthesis"
xref: Reactome:507537 "Coenzyme A biosynthesis"
xref: Reactome:517520 "Coenzyme A biosynthesis"
xref: Reactome:526389 "Coenzyme A biosynthesis"
xref: Reactome:531200 "Coenzyme A biosynthesis"
xref: Reactome:536575 "Coenzyme A biosynthesis"
xref: Reactome:542301 "Coenzyme A biosynthesis"
xref: Reactome:547642 "Coenzyme A biosynthesis"
xref: Reactome:552234 "Coenzyme A biosynthesis"
xref: Reactome:557847 "Coenzyme A biosynthesis"
xref: Reactome:568441 "Coenzyme A biosynthesis"
xref: Reactome:581654 "Coenzyme A biosynthesis"
xref: Reactome:585805 "Coenzyme A biosynthesis"
xref: Reactome:592566 "Coenzyme A biosynthesis"
xref: Reactome:595454 "Coenzyme A biosynthesis"
xref: Reactome:597440 "Coenzyme A biosynthesis"
xref: Reactome:598135 "Coenzyme A biosynthesis"
xref: Reactome:599778 "Coenzyme A biosynthesis"
xref: Reactome:600696 "Coenzyme A biosynthesis"
xref: Reactome:602609 "Coenzyme A biosynthesis"
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0051188 ! cofactor biosynthetic process

[Term]
id: GO:0009109
name: coenzyme catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
subset: gosubset_prok
synonym: "coenzyme and prosthetic group catabolic process" BROAD []
synonym: "coenzyme and prosthetic group catabolism" BROAD []
synonym: "coenzyme breakdown" EXACT []
synonym: "coenzyme catabolism" EXACT []
synonym: "coenzyme degradation" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0051187 ! cofactor catabolic process

[Term]
id: GO:0009110
name: vitamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "vitamin anabolism" EXACT []
synonym: "vitamin biosynthesis" EXACT []
synonym: "vitamin formation" EXACT []
synonym: "vitamin synthesis" EXACT []
is_a: GO:0006766 ! vitamin metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process

[Term]
id: GO:0009111
name: vitamin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin breakdown" EXACT []
synonym: "vitamin catabolism" EXACT []
synonym: "vitamin degradation" EXACT []
is_a: GO:0006766 ! vitamin metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044282 ! small molecule catabolic process

[Term]
id: GO:0009112
name: nucleobase metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma]
subset: gosubset_prok
synonym: "nucleobase metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process

[Term]
id: GO:0009113
name: purine base biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine base anabolism" EXACT []
synonym: "purine base biosynthesis" EXACT []
synonym: "purine base formation" EXACT []
synonym: "purine base synthesis" EXACT []
xref: MetaCyc:PWY-841
is_a: GO:0006144 ! purine base metabolic process
is_a: GO:0046112 ! nucleobase biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0009114
name: hypoxanthine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]
subset: gosubset_prok
synonym: "hypoxanthine breakdown" EXACT []
synonym: "hypoxanthine catabolism" EXACT []
synonym: "hypoxanthine degradation" EXACT []
is_a: GO:0006145 ! purine base catabolic process
is_a: GO:0046100 ! hypoxanthine metabolic process

[Term]
id: GO:0009115
name: xanthine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "xanthine breakdown" EXACT []
synonym: "xanthine catabolism" EXACT []
synonym: "xanthine degradation" EXACT []
is_a: GO:0006145 ! purine base catabolic process
is_a: GO:0046110 ! xanthine metabolic process

[Term]
id: GO:0009116
name: nucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma]
subset: goslim_pir
subset: gosubset_prok
synonym: "nucleoside metabolism" EXACT []
is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process

[Term]
id: GO:0009117
name: nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma]
subset: goslim_pir
subset: gosubset_prok
synonym: "nucleotide metabolism" EXACT []
is_a: GO:0006753 ! nucleoside phosphate metabolic process

[Term]
id: GO:0009118
name: regulation of nucleoside metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of nucleoside metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
relationship: regulates GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0009119
name: ribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "ribonucleoside metabolism" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0009120
name: deoxyribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713]
subset: gosubset_prok
synonym: "deoxyribonucleoside metabolism" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0009123
name: nucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "nucleoside monophosphate metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0009124
name: nucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "nucleoside monophosphate anabolism" EXACT []
synonym: "nucleoside monophosphate biosynthesis" EXACT []
synonym: "nucleoside monophosphate formation" EXACT []
synonym: "nucleoside monophosphate synthesis" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process
is_a: GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0009125
name: nucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "nucleoside monophosphate breakdown" EXACT []
synonym: "nucleoside monophosphate catabolism" EXACT []
synonym: "nucleoside monophosphate degradation" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process
is_a: GO:0009166 ! nucleotide catabolic process

[Term]
id: GO:0009126
name: purine nucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine nucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine nucleoside monophosphate metabolism" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009123 ! nucleoside monophosphate metabolic process

[Term]
id: GO:0009127
name: purine nucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine nucleoside monophosphate anabolism" EXACT []
synonym: "purine nucleoside monophosphate biosynthesis" EXACT []
synonym: "purine nucleoside monophosphate formation" EXACT []
synonym: "purine nucleoside monophosphate synthesis" EXACT []
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process
is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process

[Term]
id: GO:0009128
name: purine nucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine nucleoside monophosphate breakdown" EXACT []
synonym: "purine nucleoside monophosphate catabolism" EXACT []
synonym: "purine nucleoside monophosphate degradation" EXACT []
is_a: GO:0006195 ! purine nucleotide catabolic process
is_a: GO:0009125 ! nucleoside monophosphate catabolic process
is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process

[Term]
id: GO:0009129
name: pyrimidine nucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine nucleoside monophosphate metabolism" EXACT []
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0009123 ! nucleoside monophosphate metabolic process

[Term]
id: GO:0009130
name: pyrimidine nucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine nucleoside monophosphate anabolism" EXACT []
synonym: "pyrimidine nucleoside monophosphate biosynthesis" EXACT []
synonym: "pyrimidine nucleoside monophosphate formation" EXACT []
synonym: "pyrimidine nucleoside monophosphate synthesis" EXACT []
is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process
is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process
is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process

[Term]
id: GO:0009131
name: pyrimidine nucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine nucleoside monophosphate breakdown" EXACT []
synonym: "pyrimidine nucleoside monophosphate catabolism" EXACT []
synonym: "pyrimidine nucleoside monophosphate degradation" EXACT []
is_a: GO:0006244 ! pyrimidine nucleotide catabolic process
is_a: GO:0009125 ! nucleoside monophosphate catabolic process
is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process

[Term]
id: GO:0009132
name: nucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "nucleoside diphosphate metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0009133
name: nucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "nucleoside diphosphate anabolism" EXACT []
synonym: "nucleoside diphosphate biosynthesis" EXACT []
synonym: "nucleoside diphosphate formation" EXACT []
synonym: "nucleoside diphosphate synthesis" EXACT []
is_a: GO:0009132 ! nucleoside diphosphate metabolic process
is_a: GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0009134
name: nucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "nucleoside diphosphate breakdown" EXACT []
synonym: "nucleoside diphosphate catabolism" EXACT []
synonym: "nucleoside diphosphate degradation" EXACT []
is_a: GO:0009132 ! nucleoside diphosphate metabolic process
is_a: GO:0009166 ! nucleotide catabolic process

[Term]
id: GO:0009135
name: purine nucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine nucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine nucleoside diphosphate metabolism" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009132 ! nucleoside diphosphate metabolic process

[Term]
id: GO:0009136
name: purine nucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine nucleoside diphosphate anabolism" EXACT []
synonym: "purine nucleoside diphosphate biosynthesis" EXACT []
synonym: "purine nucleoside diphosphate formation" EXACT []
synonym: "purine nucleoside diphosphate synthesis" EXACT []
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process
is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process

[Term]
id: GO:0009137
name: purine nucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine nucleoside diphosphate breakdown" EXACT []
synonym: "purine nucleoside diphosphate catabolism" EXACT []
synonym: "purine nucleoside diphosphate degradation" EXACT []
is_a: GO:0006195 ! purine nucleotide catabolic process
is_a: GO:0009134 ! nucleoside diphosphate catabolic process
is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process

[Term]
id: GO:0009138
name: pyrimidine nucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine nucleoside diphosphate metabolism" EXACT []
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0009132 ! nucleoside diphosphate metabolic process

[Term]
id: GO:0009139
name: pyrimidine nucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine nucleoside diphosphate anabolism" EXACT []
synonym: "pyrimidine nucleoside diphosphate biosynthesis" EXACT []
synonym: "pyrimidine nucleoside diphosphate formation" EXACT []
synonym: "pyrimidine nucleoside diphosphate synthesis" EXACT []
is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process
is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process
is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process

[Term]
id: GO:0009140
name: pyrimidine nucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine nucleoside diphosphate breakdown" EXACT []
synonym: "pyrimidine nucleoside diphosphate catabolism" EXACT []
synonym: "pyrimidine nucleoside diphosphate degradation" EXACT []
is_a: GO:0006244 ! pyrimidine nucleotide catabolic process
is_a: GO:0009134 ! nucleoside diphosphate catabolic process
is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process

[Term]
id: GO:0009141
name: nucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "nucleoside triphosphate metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0009142
name: nucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "nucleoside triphosphate anabolism" EXACT []
synonym: "nucleoside triphosphate biosynthesis" EXACT []
synonym: "nucleoside triphosphate formation" EXACT []
synonym: "nucleoside triphosphate synthesis" EXACT []
is_a: GO:0009141 ! nucleoside triphosphate metabolic process
is_a: GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0009143
name: nucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "nucleoside triphosphate breakdown" EXACT []
synonym: "nucleoside triphosphate catabolism" EXACT []
synonym: "nucleoside triphosphate degradation" EXACT []
is_a: GO:0009141 ! nucleoside triphosphate metabolic process
is_a: GO:0009166 ! nucleotide catabolic process

[Term]
id: GO:0009144
name: purine nucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine nucleoside triphosphate metabolism" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009141 ! nucleoside triphosphate metabolic process

[Term]
id: GO:0009145
name: purine nucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine nucleoside triphosphate anabolism" EXACT []
synonym: "purine nucleoside triphosphate biosynthesis" EXACT []
synonym: "purine nucleoside triphosphate formation" EXACT []
synonym: "purine nucleoside triphosphate synthesis" EXACT []
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process
is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process

[Term]
id: GO:0009146
name: purine nucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine nucleoside triphosphate breakdown" EXACT []
synonym: "purine nucleoside triphosphate catabolism" EXACT []
synonym: "purine nucleoside triphosphate degradation" EXACT []
is_a: GO:0006195 ! purine nucleotide catabolic process
is_a: GO:0009143 ! nucleoside triphosphate catabolic process
is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process

[Term]
id: GO:0009147
name: pyrimidine nucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine nucleoside triphosphate metabolism" EXACT []
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0009141 ! nucleoside triphosphate metabolic process

[Term]
id: GO:0009148
name: pyrimidine nucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine nucleoside triphosphate anabolism" EXACT []
synonym: "pyrimidine nucleoside triphosphate biosynthesis" EXACT []
synonym: "pyrimidine nucleoside triphosphate formation" EXACT []
synonym: "pyrimidine nucleoside triphosphate synthesis" EXACT []
is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process
is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process
is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process

[Term]
id: GO:0009149
name: pyrimidine nucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine nucleoside triphosphate breakdown" EXACT []
synonym: "pyrimidine nucleoside triphosphate catabolism" EXACT []
synonym: "pyrimidine nucleoside triphosphate degradation" EXACT []
is_a: GO:0006244 ! pyrimidine nucleotide catabolic process
is_a: GO:0009143 ! nucleoside triphosphate catabolic process
is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process

[Term]
id: GO:0009150
name: purine ribonucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine ribonucleotide metabolism" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009259 ! ribonucleotide metabolic process

[Term]
id: GO:0009151
name: purine deoxyribonucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine deoxyribonucleotide metabolism" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process

[Term]
id: GO:0009152
name: purine ribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine ribonucleotide anabolism" EXACT []
synonym: "purine ribonucleotide biosynthesis" EXACT []
synonym: "purine ribonucleotide formation" EXACT []
synonym: "purine ribonucleotide synthesis" EXACT []
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009260 ! ribonucleotide biosynthetic process

[Term]
id: GO:0009153
name: purine deoxyribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine deoxyribonucleotide anabolism" EXACT []
synonym: "purine deoxyribonucleotide biosynthesis" EXACT []
synonym: "purine deoxyribonucleotide formation" EXACT []
synonym: "purine deoxyribonucleotide synthesis" EXACT []
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process

[Term]
id: GO:0009154
name: purine ribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine ribonucleotide breakdown" EXACT []
synonym: "purine ribonucleotide catabolism" EXACT []
synonym: "purine ribonucleotide degradation" EXACT []
is_a: GO:0006195 ! purine nucleotide catabolic process
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009261 ! ribonucleotide catabolic process

[Term]
id: GO:0009155
name: purine deoxyribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine deoxyribonucleotide breakdown" EXACT []
synonym: "purine deoxyribonucleotide catabolism" EXACT []
synonym: "purine deoxyribonucleotide degradation" EXACT []
is_a: GO:0006195 ! purine nucleotide catabolic process
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009264 ! deoxyribonucleotide catabolic process

[Term]
id: GO:0009156
name: ribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ribonucleoside monophosphate anabolism" EXACT []
synonym: "ribonucleoside monophosphate biosynthesis" EXACT []
synonym: "ribonucleoside monophosphate formation" EXACT []
synonym: "ribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process
is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process
is_a: GO:0009260 ! ribonucleotide biosynthetic process

[Term]
id: GO:0009157
name: deoxyribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "deoxyribonucleoside monophosphate anabolism" EXACT []
synonym: "deoxyribonucleoside monophosphate biosynthesis" EXACT []
synonym: "deoxyribonucleoside monophosphate formation" EXACT []
synonym: "deoxyribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process
is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process
is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process

[Term]
id: GO:0009158
name: ribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ribonucleoside monophosphate breakdown" EXACT []
synonym: "ribonucleoside monophosphate catabolism" EXACT []
synonym: "ribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009125 ! nucleoside monophosphate catabolic process
is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process
is_a: GO:0009261 ! ribonucleotide catabolic process

[Term]
id: GO:0009159
name: deoxyribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "deoxyribonucleoside monophosphate breakdown" EXACT []
synonym: "deoxyribonucleoside monophosphate catabolism" EXACT []
synonym: "deoxyribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009125 ! nucleoside monophosphate catabolic process
is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process
is_a: GO:0009264 ! deoxyribonucleotide catabolic process

[Term]
id: GO:0009161
name: ribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process
is_a: GO:0009259 ! ribonucleotide metabolic process

[Term]
id: GO:0009162
name: deoxyribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "deoxyribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process
is_a: GO:0009262 ! deoxyribonucleotide metabolic process

[Term]
id: GO:0009163
name: nucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713]
subset: gosubset_prok
synonym: "nucleoside anabolism" EXACT []
synonym: "nucleoside biosynthesis" EXACT []
synonym: "nucleoside formation" EXACT []
synonym: "nucleoside synthesis" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process
is_a: GO:0034404 ! nucleobase, nucleoside and nucleotide biosynthetic process

[Term]
id: GO:0009164
name: nucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl]
subset: gosubset_prok
synonym: "nucleoside breakdown" EXACT []
synonym: "nucleoside catabolism" EXACT []
synonym: "nucleoside degradation" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process
is_a: GO:0034656 ! nucleobase, nucleoside and nucleotide catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0009165
name: nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]
subset: gosubset_prok
synonym: "nucleotide anabolism" EXACT []
synonym: "nucleotide biosynthesis" EXACT []
synonym: "nucleotide formation" EXACT []
synonym: "nucleotide synthesis" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0009166
name: nucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators]
subset: gosubset_prok
synonym: "nucleotide breakdown" EXACT []
synonym: "nucleotide catabolism" EXACT []
synonym: "nucleotide degradation" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0009167
name: purine ribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine ribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009168
name: purine ribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine ribonucleoside monophosphate anabolism" EXACT []
synonym: "purine ribonucleoside monophosphate biosynthesis" EXACT []
synonym: "purine ribonucleoside monophosphate formation" EXACT []
synonym: "purine ribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009169
name: purine ribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine ribonucleoside monophosphate breakdown" EXACT []
synonym: "purine ribonucleoside monophosphate catabolism" EXACT []
synonym: "purine ribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0009170
name: purine deoxyribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009171
name: purine deoxyribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside monophosphate anabolism" EXACT []
synonym: "purine deoxyribonucleoside monophosphate biosynthesis" EXACT []
synonym: "purine deoxyribonucleoside monophosphate formation" EXACT []
synonym: "purine deoxyribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process
is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process
is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009172
name: purine deoxyribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside monophosphate breakdown" EXACT []
synonym: "purine deoxyribonucleoside monophosphate catabolism" EXACT []
synonym: "purine deoxyribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process
is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0009173
name: pyrimidine ribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process
is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process

[Term]
id: GO:0009174
name: pyrimidine ribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside monophosphate anabolism" EXACT []
synonym: "pyrimidine ribonucleoside monophosphate biosynthesis" EXACT []
synonym: "pyrimidine ribonucleoside monophosphate formation" EXACT []
synonym: "pyrimidine ribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process
is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process
is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process

[Term]
id: GO:0009175
name: pyrimidine ribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside monophosphate breakdown" EXACT []
synonym: "pyrimidine ribonucleoside monophosphate catabolism" EXACT []
synonym: "pyrimidine ribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process
is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process
is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process

[Term]
id: GO:0009176
name: pyrimidine deoxyribonucleoside monophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside monophosphate metabolism" EXACT []
is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process
is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0009177
name: pyrimidine deoxyribonucleoside monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxynucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside monophosphate anabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside monophosphate biosynthesis" EXACT []
synonym: "pyrimidine deoxyribonucleoside monophosphate formation" EXACT []
synonym: "pyrimidine deoxyribonucleoside monophosphate synthesis" EXACT []
is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process
is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process

[Term]
id: GO:0009178
name: pyrimidine deoxyribonucleoside monophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside monophosphate breakdown" EXACT []
synonym: "pyrimidine deoxyribonucleoside monophosphate catabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside monophosphate degradation" EXACT []
is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process
is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process
is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process

[Term]
id: GO:0009179
name: purine ribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine ribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process

[Term]
id: GO:0009180
name: purine ribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine ribonucleoside diphosphate anabolism" EXACT []
synonym: "purine ribonucleoside diphosphate biosynthesis" EXACT []
synonym: "purine ribonucleoside diphosphate formation" EXACT []
synonym: "purine ribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process
is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process

[Term]
id: GO:0009181
name: purine ribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine ribonucleoside diphosphate breakdown" EXACT []
synonym: "purine ribonucleoside diphosphate catabolism" EXACT []
synonym: "purine ribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process
is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process

[Term]
id: GO:0009182
name: purine deoxyribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine deoxyribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0009183
name: purine deoxyribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside diphosphate anabolism" EXACT []
synonym: "purine deoxyribonucleoside diphosphate biosynthesis" EXACT []
synonym: "purine deoxyribonucleoside diphosphate formation" EXACT []
synonym: "purine deoxyribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process
is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process
is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process

[Term]
id: GO:0009184
name: purine deoxyribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside diphosphate breakdown" EXACT []
synonym: "purine deoxyribonucleoside diphosphate catabolism" EXACT []
synonym: "purine deoxyribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process

[Term]
id: GO:0009185
name: ribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a ribonucleoside diphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009132 ! nucleoside diphosphate metabolic process
is_a: GO:0009259 ! ribonucleotide metabolic process

[Term]
id: GO:0009186
name: deoxyribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "deoxyribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009132 ! nucleoside diphosphate metabolic process
is_a: GO:0009262 ! deoxyribonucleotide metabolic process

[Term]
id: GO:0009187
name: cyclic nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cyclic nucleotide metabolism" EXACT []
is_a: GO:0009123 ! nucleoside monophosphate metabolic process

[Term]
id: GO:0009188
name: ribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ribonucleoside diphosphate anabolism" EXACT []
synonym: "ribonucleoside diphosphate biosynthesis" EXACT []
synonym: "ribonucleoside diphosphate formation" EXACT []
synonym: "ribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process
is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process
is_a: GO:0009260 ! ribonucleotide biosynthetic process

[Term]
id: GO:0009189
name: deoxyribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "deoxyribonucleoside diphosphate anabolism" EXACT []
synonym: "deoxyribonucleoside diphosphate biosynthesis" EXACT []
synonym: "deoxyribonucleoside diphosphate formation" EXACT []
synonym: "deoxyribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process
is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process

[Term]
id: GO:0009190
name: cyclic nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cyclic nucleotide anabolism" EXACT []
synonym: "cyclic nucleotide biosynthesis" EXACT []
synonym: "cyclic nucleotide formation" EXACT []
synonym: "cyclic nucleotide synthesis" EXACT []
is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process
is_a: GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0009191
name: ribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ribonucleoside diphosphate breakdown" EXACT []
synonym: "ribonucleoside diphosphate catabolism" EXACT []
synonym: "ribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009134 ! nucleoside diphosphate catabolic process
is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process
is_a: GO:0009261 ! ribonucleotide catabolic process

[Term]
id: GO:0009192
name: deoxyribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "deoxyribonucleoside diphosphate breakdown" EXACT []
synonym: "deoxyribonucleoside diphosphate catabolism" EXACT []
synonym: "deoxyribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009134 ! nucleoside diphosphate catabolic process
is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009264 ! deoxyribonucleotide catabolic process

[Term]
id: GO:0009193
name: pyrimidine ribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process
is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process

[Term]
id: GO:0009194
name: pyrimidine ribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside diphosphate anabolism" EXACT []
synonym: "pyrimidine ribonucleoside diphosphate biosynthesis" EXACT []
synonym: "pyrimidine ribonucleoside diphosphate formation" EXACT []
synonym: "pyrimidine ribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process
is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process
is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process

[Term]
id: GO:0009195
name: pyrimidine ribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside diphosphate breakdown" EXACT []
synonym: "pyrimidine ribonucleoside diphosphate catabolism" EXACT []
synonym: "pyrimidine ribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process
is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process
is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process

[Term]
id: GO:0009196
name: pyrimidine deoxyribonucleoside diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside diphosphate metabolism" EXACT []
is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process
is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process

[Term]
id: GO:0009197
name: pyrimidine deoxyribonucleoside diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside diphosphate anabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside diphosphate biosynthesis" EXACT []
synonym: "pyrimidine deoxyribonucleoside diphosphate formation" EXACT []
synonym: "pyrimidine deoxyribonucleoside diphosphate synthesis" EXACT []
is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process
is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process
is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process

[Term]
id: GO:0009198
name: pyrimidine deoxyribonucleoside diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside diphosphate breakdown" EXACT []
synonym: "pyrimidine deoxyribonucleoside diphosphate catabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside diphosphate degradation" EXACT []
is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process
is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process
is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process

[Term]
id: GO:0009199
name: ribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009141 ! nucleoside triphosphate metabolic process
is_a: GO:0009259 ! ribonucleotide metabolic process

[Term]
id: GO:0009200
name: deoxyribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "deoxyribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009141 ! nucleoside triphosphate metabolic process
is_a: GO:0009262 ! deoxyribonucleotide metabolic process

[Term]
id: GO:0009201
name: ribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ribonucleoside triphosphate anabolism" EXACT []
synonym: "ribonucleoside triphosphate biosynthesis" EXACT []
synonym: "ribonucleoside triphosphate formation" EXACT []
synonym: "ribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process
is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process
is_a: GO:0009260 ! ribonucleotide biosynthetic process

[Term]
id: GO:0009202
name: deoxyribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "deoxyribonucleoside triphosphate anabolism" EXACT []
synonym: "deoxyribonucleoside triphosphate biosynthesis" EXACT []
synonym: "deoxyribonucleoside triphosphate formation" EXACT []
synonym: "deoxyribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process
is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process
is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process

[Term]
id: GO:0009203
name: ribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ribonucleoside triphosphate breakdown" EXACT []
synonym: "ribonucleoside triphosphate catabolism" EXACT []
synonym: "ribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009143 ! nucleoside triphosphate catabolic process
is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process
is_a: GO:0009261 ! ribonucleotide catabolic process

[Term]
id: GO:0009204
name: deoxyribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "deoxyribonucleoside triphosphate breakdown" EXACT []
synonym: "deoxyribonucleoside triphosphate catabolism" EXACT []
synonym: "deoxyribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009143 ! nucleoside triphosphate catabolic process
is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process
is_a: GO:0009264 ! deoxyribonucleotide catabolic process

[Term]
id: GO:0009205
name: purine ribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine ribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process
is_a: GO:0009150 ! purine ribonucleotide metabolic process
is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009206
name: purine ribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine ribonucleoside triphosphate anabolism" EXACT []
synonym: "purine ribonucleoside triphosphate biosynthesis" EXACT []
synonym: "purine ribonucleoside triphosphate formation" EXACT []
synonym: "purine ribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process
is_a: GO:0009152 ! purine ribonucleotide biosynthetic process
is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process
is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009207
name: purine ribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine ribonucleoside triphosphate breakdown" EXACT []
synonym: "purine ribonucleoside triphosphate catabolism" EXACT []
synonym: "purine ribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process
is_a: GO:0009154 ! purine ribonucleotide catabolic process
is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process
is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0009208
name: pyrimidine ribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process
is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process

[Term]
id: GO:0009209
name: pyrimidine ribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside triphosphate anabolism" EXACT []
synonym: "pyrimidine ribonucleoside triphosphate biosynthesis" EXACT []
synonym: "pyrimidine ribonucleoside triphosphate formation" EXACT []
synonym: "pyrimidine ribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process
is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process
is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process

[Term]
id: GO:0009210
name: pyrimidine ribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside triphosphate breakdown" EXACT []
synonym: "pyrimidine ribonucleoside triphosphate catabolism" EXACT []
synonym: "pyrimidine ribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process
is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process
is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process
is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process

[Term]
id: GO:0009211
name: pyrimidine deoxyribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process
is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process

[Term]
id: GO:0009212
name: pyrimidine deoxyribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside triphosphate anabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside triphosphate biosynthesis" EXACT []
synonym: "pyrimidine deoxyribonucleoside triphosphate formation" EXACT []
synonym: "pyrimidine deoxyribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process
is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process

[Term]
id: GO:0009213
name: pyrimidine deoxyribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxyribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside triphosphate breakdown" EXACT []
synonym: "pyrimidine deoxyribonucleoside triphosphate catabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process
is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process
is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process

[Term]
id: GO:0009214
name: cyclic nucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cyclic nucleotide breakdown" EXACT []
synonym: "cyclic nucleotide catabolism" EXACT []
synonym: "cyclic nucleotide degradation" EXACT []
is_a: GO:0009125 ! nucleoside monophosphate catabolic process
is_a: GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0009215
name: purine deoxyribonucleoside triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside triphosphate metabolism" EXACT []
is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process
is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process
is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009216
name: purine deoxyribonucleoside triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside triphosphate anabolism" EXACT []
synonym: "purine deoxyribonucleoside triphosphate biosynthesis" EXACT []
synonym: "purine deoxyribonucleoside triphosphate formation" EXACT []
synonym: "purine deoxyribonucleoside triphosphate synthesis" EXACT []
is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process
is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process
is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009217
name: purine deoxyribonucleoside triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside triphosphate breakdown" EXACT []
synonym: "purine deoxyribonucleoside triphosphate catabolism" EXACT []
synonym: "purine deoxyribonucleoside triphosphate degradation" EXACT []
is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process
is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process
is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0009218
name: pyrimidine ribonucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine ribonucleotide metabolism" EXACT []
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0009259 ! ribonucleotide metabolic process

[Term]
id: GO:0009219
name: pyrimidine deoxyribonucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleotide metabolism" EXACT []
is_a: GO:0006220 ! pyrimidine nucleotide metabolic process
is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process

[Term]
id: GO:0009220
name: pyrimidine ribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine ribonucleotide anabolism" EXACT []
synonym: "pyrimidine ribonucleotide biosynthesis" EXACT []
synonym: "pyrimidine ribonucleotide formation" EXACT []
synonym: "pyrimidine ribonucleotide synthesis" EXACT []
xref: MetaCyc:PWY0-162
is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process
is_a: GO:0009260 ! ribonucleotide biosynthetic process

[Term]
id: GO:0009221
name: pyrimidine deoxyribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleotide anabolism" EXACT []
synonym: "pyrimidine deoxyribonucleotide biosynthesis" EXACT []
synonym: "pyrimidine deoxyribonucleotide formation" EXACT []
synonym: "pyrimidine deoxyribonucleotide synthesis" EXACT []
xref: MetaCyc:PWY0-166
is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process
is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process

[Term]
id: GO:0009222
name: pyrimidine ribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine ribonucleotide breakdown" EXACT []
synonym: "pyrimidine ribonucleotide catabolism" EXACT []
synonym: "pyrimidine ribonucleotide degradation" EXACT []
is_a: GO:0006244 ! pyrimidine nucleotide catabolic process
is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process
is_a: GO:0009261 ! ribonucleotide catabolic process

[Term]
id: GO:0009223
name: pyrimidine deoxyribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleotide breakdown" EXACT []
synonym: "pyrimidine deoxyribonucleotide catabolism" EXACT []
synonym: "pyrimidine deoxyribonucleotide degradation" EXACT []
is_a: GO:0006244 ! pyrimidine nucleotide catabolic process
is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process
is_a: GO:0009264 ! deoxyribonucleotide catabolic process

[Term]
id: GO:0009224
name: CMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CMP, cytidine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "CMP anabolism" EXACT []
synonym: "CMP biosynthesis" EXACT []
synonym: "CMP formation" EXACT []
synonym: "CMP synthesis" EXACT []
is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process
is_a: GO:0046035 ! CMP metabolic process

[Term]
id: GO:0009225
name: nucleotide-sugar metabolic process
namespace: biological_process
def: "The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
synonym: "nucleotide-sugar metabolism" EXACT []
is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

[Term]
id: GO:0009226
name: nucleotide-sugar biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "nucleotide-sugar anabolism" EXACT []
synonym: "nucleotide-sugar biosynthesis" EXACT []
synonym: "nucleotide-sugar formation" EXACT []
synonym: "nucleotide-sugar synthesis" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0009227
name: nucleotide-sugar catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "nucleotide-sugar breakdown" EXACT []
synonym: "nucleotide-sugar catabolism" EXACT []
synonym: "nucleotide-sugar degradation" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0009228
name: thiamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "thiamin anabolism" EXACT []
synonym: "thiamin biosynthesis" EXACT []
synonym: "thiamin formation" EXACT []
synonym: "thiamin synthesis" EXACT []
synonym: "thiamine biosynthesis" EXACT []
synonym: "thiamine biosynthetic process" EXACT []
synonym: "vitamin B1 biosynthesis" EXACT []
synonym: "vitamin B1 biosynthetic process" EXACT []
xref: MetaCyc:THISYN-PWY
is_a: GO:0006772 ! thiamin metabolic process
is_a: GO:0042724 ! thiamin and derivative biosynthetic process

[Term]
id: GO:0009229
name: thiamin diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thiamin diphosphate, a derivative of thiamin (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0140512713]
subset: gosubset_prok
synonym: "thiamin diphosphate anabolism" EXACT []
synonym: "thiamin diphosphate biosynthesis" EXACT []
synonym: "thiamin diphosphate formation" EXACT []
synonym: "thiamin diphosphate synthesis" EXACT []
synonym: "thiamin pyrophosphate biosynthesis" EXACT []
synonym: "thiamin pyrophosphate biosynthetic process" EXACT []
synonym: "thiamine diphosphate biosynthesis" EXACT []
synonym: "thiamine diphosphate biosynthetic process" EXACT []
synonym: "thiamine pyrophosphate biosynthesis" EXACT []
synonym: "thiamine pyrophosphate biosynthetic process" EXACT []
synonym: "TPP biosynthesis" EXACT []
synonym: "TPP biosynthetic process" EXACT []
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0042357 ! thiamin diphosphate metabolic process
is_a: GO:0042724 ! thiamin and derivative biosynthetic process

[Term]
id: GO:0009230
name: thiamin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "thiamin breakdown" EXACT []
synonym: "thiamin catabolism" EXACT []
synonym: "thiamin degradation" EXACT []
synonym: "thiamine catabolic process" EXACT []
synonym: "thiamine catabolism" EXACT []
synonym: "vitamin B1 catabolic process" EXACT []
synonym: "vitamin B1 catabolism" EXACT []
is_a: GO:0006772 ! thiamin metabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0042725 ! thiamin and derivative catabolic process

[Term]
id: GO:0009231
name: riboflavin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "riboflavin anabolism" EXACT []
synonym: "riboflavin biosynthesis" EXACT []
synonym: "riboflavin formation" EXACT []
synonym: "riboflavin synthesis" EXACT []
synonym: "vitamin B2 biosynthesis" EXACT []
synonym: "vitamin B2 biosynthetic process" EXACT []
synonym: "vitamin G biosynthesis" EXACT []
synonym: "vitamin G biosynthetic process" EXACT []
xref: MetaCyc:RIBOSYN2-PWY
xref: Wikipedia:Riboflavin
is_a: GO:0006771 ! riboflavin metabolic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0042727 ! riboflavin and derivative biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process

[Term]
id: GO:0009232
name: riboflavin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "riboflavin breakdown" EXACT []
synonym: "riboflavin catabolism" EXACT []
synonym: "riboflavin degradation" EXACT []
synonym: "vitamin B2 catabolic process" EXACT []
synonym: "vitamin B2 catabolism" EXACT []
synonym: "vitamin G catabolic process" EXACT []
synonym: "vitamin G catabolism" EXACT []
is_a: GO:0006771 ! riboflavin metabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0042728 ! riboflavin and derivative catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0009233
name: menaquinone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of the menaquinones, quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "menaquinone metabolism" EXACT []
synonym: "menatetrenone metabolic process" EXACT []
synonym: "menatetrenone metabolism" EXACT []
synonym: "multiprenylmenaquinone metabolic process" EXACT []
synonym: "multiprenylmenaquinone metabolism" EXACT []
synonym: "vitamin K2 metabolic process" EXACT []
synonym: "vitamin K2 metabolism" EXACT []
is_a: GO:0042373 ! vitamin K metabolic process

[Term]
id: GO:0009234
name: menaquinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of the menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "menaquinone anabolism" EXACT []
synonym: "menaquinone biosynthesis" EXACT []
synonym: "menaquinone formation" EXACT []
synonym: "menaquinone synthesis" EXACT []
synonym: "menatetrenone biosynthesis" EXACT []
synonym: "menatetrenone biosynthetic process" EXACT []
synonym: "multiprenylmenaquinone biosynthesis" EXACT []
synonym: "multiprenylmenaquinone biosynthetic process" EXACT []
synonym: "vitamin K2 biosynthesis" EXACT []
synonym: "vitamin K2 biosynthetic process" EXACT []
xref: MetaCyc:MENAQUINONESYN-PWY
is_a: GO:0009233 ! menaquinone metabolic process
is_a: GO:0042371 ! vitamin K biosynthetic process

[Term]
id: GO:0009235
name: cobalamin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators]
subset: gosubset_prok
synonym: "cobalamin metabolism" EXACT []
synonym: "vitamin B12 metabolic process" EXACT []
synonym: "vitamin B12 metabolism" EXACT []
synonym: "vitamin B12 reduction" NARROW []
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0006778 ! porphyrin metabolic process

[Term]
id: GO:0009236
name: cobalamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cobalamin anabolism" EXACT []
synonym: "cobalamin biosynthesis" EXACT []
synonym: "cobalamin formation" EXACT []
synonym: "cobalamin synthesis" EXACT []
synonym: "vitamin B12 biosynthesis" EXACT []
synonym: "vitamin B12 biosynthetic process" EXACT []
is_a: GO:0006779 ! porphyrin biosynthetic process
is_a: GO:0009235 ! cobalamin metabolic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process

[Term]
id: GO:0009237
name: siderophore metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [ISBN:0198547684]
subset: gosubset_prok
synonym: "siderochrome metabolic process" NARROW []
synonym: "siderochrome metabolism" NARROW []
synonym: "siderophore metabolism" EXACT []
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0009238
name: enterobactin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [ISBN:0198547684]
subset: gosubset_prok
synonym: "enterobactin metabolism" EXACT []
synonym: "enterochelin metabolic process" EXACT []
synonym: "enterochelin metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0009237 ! siderophore metabolic process

[Term]
id: GO:0009239
name: enterobactin biosynthetic process
namespace: biological_process
alt_id: GO:0031191
alt_id: GO:0031192
def: "The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [GOC:go_curators]
subset: gosubset_prok
synonym: "enterobactin anabolism" EXACT []
synonym: "enterobactin biosynthesis" EXACT []
synonym: "enterobactin biosynthetic process, peptide formation" NARROW []
synonym: "enterobactin biosynthetic process, peptide modification" NARROW []
synonym: "enterobactin formation" EXACT []
synonym: "enterobactin synthesis" EXACT []
synonym: "enterobactin synthetase" RELATED []
synonym: "enterochelin biosynthesis" EXACT []
synonym: "enterochelin biosynthetic process" EXACT []
xref: MetaCyc:ENTBACSYN-PWY
is_a: GO:0009238 ! enterobactin metabolic process
is_a: GO:0019540 ! siderophore biosynthetic process from catechol

[Term]
id: GO:0009240
name: isopentenyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "IPP biosynthesis" EXACT []
synonym: "IPP biosynthetic process" EXACT []
synonym: "isopentenyl diphosphate anabolism" EXACT []
synonym: "isopentenyl diphosphate biosynthesis" EXACT []
synonym: "isopentenyl diphosphate formation" EXACT []
synonym: "isopentenyl diphosphate synthesis" EXACT []
synonym: "isopentenyl pyrophosphate biosynthesis" EXACT []
synonym: "isopentenyl pyrophosphate biosynthetic process" EXACT []
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0046490 ! isopentenyl diphosphate metabolic process
relationship: part_of GO:0008299 ! isoprenoid biosynthetic process

[Term]
id: GO:0009242
name: colanic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide." [GOC:ai]
subset: gosubset_prok
synonym: "colanic acid anabolism" EXACT []
synonym: "colanic acid biosynthesis" EXACT []
synonym: "colanic acid formation" EXACT []
synonym: "colanic acid synthesis" EXACT []
synonym: "M antigen biosynthesis" EXACT []
synonym: "M antigen biosynthetic process" EXACT []
xref: MetaCyc:COLANSYN-PWY
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0046377 ! colanic acid metabolic process

[Term]
id: GO:0009243
name: O antigen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "O antigen anabolism" EXACT []
synonym: "O antigen biosynthesis" EXACT []
synonym: "O antigen formation" EXACT []
synonym: "O antigen synthesis" EXACT []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0046402 ! O antigen metabolic process
relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process

[Term]
id: GO:0009244
name: lipopolysaccharide core region biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "lipopolysaccharide core region anabolism" EXACT []
synonym: "lipopolysaccharide core region biosynthesis" EXACT []
synonym: "lipopolysaccharide core region formation" EXACT []
synonym: "lipopolysaccharide core region synthesis" EXACT []
synonym: "LPS core region biosynthetic process" EXACT []
is_a: GO:0009312 ! oligosaccharide biosynthetic process
is_a: GO:0046401 ! lipopolysaccharide core region metabolic process
relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process

[Term]
id: GO:0009245
name: lipid A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "lipid A anabolism" EXACT []
synonym: "lipid A biosynthesis" EXACT []
synonym: "lipid A formation" EXACT []
synonym: "lipid A synthesis" EXACT []
xref: MetaCyc:NAGLIPASYN-PWY
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0046493 ! lipid A metabolic process
relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process

[Term]
id: GO:0009246
name: enterobacterial common antigen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria." [GOC:ma]
subset: gosubset_prok
synonym: "enterobacterial common antigen anabolism" EXACT []
synonym: "enterobacterial common antigen biosynthesis" EXACT []
synonym: "enterobacterial common antigen formation" EXACT []
synonym: "enterobacterial common antigen synthesis" EXACT []
xref: MetaCyc:ECASYN-PWY
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0046378 ! enterobacterial common antigen metabolic process

[Term]
id: GO:0009247
name: glycolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycolipid, a compound containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycolipid anabolism" EXACT []
synonym: "glycolipid biosynthesis" EXACT []
synonym: "glycolipid formation" EXACT []
synonym: "glycolipid synthesis" EXACT []
xref: MetaCyc:PWY-401
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0046467 ! membrane lipid biosynthetic process

[Term]
id: GO:0009248
name: K antigen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "K antigen anabolism" EXACT []
synonym: "K antigen biosynthesis" EXACT []
synonym: "K antigen formation" EXACT []
synonym: "K antigen synthesis" EXACT []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0046375 ! K antigen metabolic process

[Term]
id: GO:0009249
name: protein lipoylation
namespace: biological_process
def: "The addition of a lipoyl group to an amino acid residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018065 ! protein-cofactor linkage

[Term]
id: GO:0009250
name: glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators]
subset: gosubset_prok
synonym: "glucan anabolism" EXACT []
synonym: "glucan biosynthesis" EXACT []
synonym: "glucan formation" EXACT []
synonym: "glucan synthesis" EXACT []
is_a: GO:0006073 ! cellular glucan metabolic process
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process

[Term]
id: GO:0009251
name: glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators]
subset: gosubset_prok
synonym: "glucan breakdown" EXACT []
synonym: "glucan catabolism" EXACT []
synonym: "glucan degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:0009252
name: peptidoglycan biosynthetic process
namespace: biological_process
alt_id: GO:0009285
def: "The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "murein biosynthesis" EXACT []
synonym: "murein biosynthetic process" EXACT []
synonym: "peptidoglycan anabolism" EXACT []
synonym: "peptidoglycan biosynthesis" EXACT []
synonym: "peptidoglycan formation" EXACT []
synonym: "peptidoglycan synthesis" EXACT []
is_a: GO:0000270 ! peptidoglycan metabolic process
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0044038 ! cell wall macromolecule biosynthetic process
relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis

[Term]
id: GO:0009253
name: peptidoglycan catabolic process
namespace: biological_process
alt_id: GO:0009286
def: "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "murein catabolic process" EXACT []
synonym: "murein catabolism" EXACT []
synonym: "peptidoglycan breakdown" EXACT []
synonym: "peptidoglycan catabolism" EXACT []
synonym: "peptidoglycan degradation" EXACT []
is_a: GO:0000270 ! peptidoglycan metabolic process
is_a: GO:0006027 ! glycosaminoglycan catabolic process

[Term]
id: GO:0009254
name: peptidoglycan turnover
namespace: biological_process
alt_id: GO:0009287
def: "The continual breakdown and regeneration of peptidoglycan required to maintain the cell wall." [GOC:jl]
subset: gosubset_prok
synonym: "murein turnover" EXACT []
is_a: GO:0000270 ! peptidoglycan metabolic process

[Term]
id: GO:0009255
name: Entner-Doudoroff pathway
namespace: biological_process
def: "A pathway that converts glucose to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it." [GOC:jl, http://cancerweb.ncl.ac.uk]
subset: gosubset_prok
xref: MetaCyc:ENTNER-DOUDOROFF-PWY
is_a: GO:0044262 ! cellular carbohydrate metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0009256
name: 10-formyltetrahydrofolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai]
subset: gosubset_prok
synonym: "10-formyl-THF metabolic process" EXACT []
synonym: "10-formyl-THF metabolism" EXACT []
synonym: "10-formyltetrahydrofolate metabolism" EXACT []
is_a: GO:0046653 ! tetrahydrofolate metabolic process

[Term]
id: GO:0009257
name: 10-formyltetrahydrofolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai]
subset: gosubset_prok
synonym: "10-formyl-THF biosynthesis" EXACT []
synonym: "10-formyl-THF biosynthetic process" EXACT []
synonym: "10-formyltetrahydrofolate anabolism" EXACT []
synonym: "10-formyltetrahydrofolate biosynthesis" EXACT []
synonym: "10-formyltetrahydrofolate formation" EXACT []
synonym: "10-formyltetrahydrofolate synthesis" EXACT []
xref: MetaCyc:1CMET2-PWY
xref: MetaCyc:PWY-3841
is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process
is_a: GO:0046654 ! tetrahydrofolate biosynthetic process

[Term]
id: GO:0009258
name: 10-formyltetrahydrofolate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai]
subset: gosubset_prok
synonym: "10-formyl-THF catabolic process" EXACT []
synonym: "10-formyl-THF catabolism" EXACT []
synonym: "10-formyltetrahydrofolate breakdown" EXACT []
synonym: "10-formyltetrahydrofolate catabolism" EXACT []
synonym: "10-formyltetrahydrofolate degradation" EXACT []
is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process
is_a: GO:0009397 ! folic acid and derivative catabolic process
is_a: GO:0042560 ! pteridine and derivative catabolic process

[Term]
id: GO:0009259
name: ribonucleotide metabolic process
namespace: biological_process
alt_id: GO:0009121
def: "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ribonucleotide metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0009260
name: ribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ribonucleotide anabolism" EXACT []
synonym: "ribonucleotide biosynthesis" EXACT []
synonym: "ribonucleotide formation" EXACT []
synonym: "ribonucleotide synthesis" EXACT []
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0009259 ! ribonucleotide metabolic process

[Term]
id: GO:0009261
name: ribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ribonucleotide breakdown" EXACT []
synonym: "ribonucleotide catabolism" EXACT []
synonym: "ribonucleotide degradation" EXACT []
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0009259 ! ribonucleotide metabolic process

[Term]
id: GO:0009262
name: deoxyribonucleotide metabolic process
namespace: biological_process
alt_id: GO:0009122
alt_id: GO:0009393
def: "The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "deoxyribonucleotide metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0009263
name: deoxyribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "deoxyribonucleotide anabolism" EXACT []
synonym: "deoxyribonucleotide biosynthesis" EXACT []
synonym: "deoxyribonucleotide formation" EXACT []
synonym: "deoxyribonucleotide synthesis" EXACT []
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0009262 ! deoxyribonucleotide metabolic process

[Term]
id: GO:0009264
name: deoxyribonucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "deoxyribonucleotide breakdown" EXACT []
synonym: "deoxyribonucleotide catabolism" EXACT []
synonym: "deoxyribonucleotide degradation" EXACT []
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0009262 ! deoxyribonucleotide metabolic process

[Term]
id: GO:0009265
name: 2'-deoxyribonucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:mah]
subset: gosubset_prok
synonym: "2'-deoxyribonucleotide anabolism" EXACT []
synonym: "2'-deoxyribonucleotide biosynthesis" EXACT []
synonym: "2'-deoxyribonucleotide formation" EXACT []
synonym: "2'-deoxyribonucleotide synthesis" EXACT []
is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process
is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process

[Term]
id: GO:0009266
name: response to temperature stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb]
subset: gosubset_prok
synonym: "response to thermal stimulus" EXACT []
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009267
name: cellular response to starvation
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl]
subset: gosubset_prok
is_a: GO:0031669 ! cellular response to nutrient levels
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0042594 ! response to starvation

[Term]
id: GO:0009268
name: response to pH
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus." [GOC:jl]
subset: gosubset_prok
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009269
name: response to desiccation
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:jl]
subset: gosubset_prok
synonym: "desiccation tolerance" RELATED []
is_a: GO:0009414 ! response to water deprivation

[Term]
id: GO:0009270
name: response to humidity
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:jl]
is_a: GO:0009415 ! response to water

[Term]
id: GO:0009271
name: phage shock
namespace: biological_process
def: "A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage." [GOC:add, GOC:jl, PMID:15485810, PMID:16045608]
subset: gosubset_prok
is_a: GO:0006950 ! response to stress
is_a: GO:0009615 ! response to virus

[Term]
id: GO:0009272
name: fungal-type cell wall biogenesis
namespace: biological_process
def: "The process by which a fungal-type cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:go_curators, GOC:mtg_sensu]
synonym: "cell wall anabolism" BROAD []
synonym: "cell wall assembly" BROAD []
synonym: "cell wall biosynthetic process" BROAD []
synonym: "cell wall formation" BROAD []
synonym: "cell wall synthesis" BROAD []
synonym: "chitin- and beta-glucan-containing cell wall biogenesis" NARROW []
is_a: GO:0042546 ! cell wall biogenesis

[Term]
id: GO:0009273
name: peptidoglycan-based cell wall biogenesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli." [GOC:go_curators]
subset: gosubset_prok
synonym: "cell envelope biosynthesis" BROAD []
synonym: "cell envelope biosynthetic process" BROAD []
synonym: "cell wall anabolism" BROAD []
synonym: "cell wall assembly" BROAD []
synonym: "cell wall biosynthetic process" BROAD []
synonym: "cell wall formation" BROAD []
synonym: "cell wall synthesis" BROAD []
is_a: GO:0042546 ! cell wall biogenesis

[Term]
id: GO:0009274
name: peptidoglycan-based cell wall
namespace: cellular_component
def: "A protective structure outside the cytoplasmic membrane composed of peptidoglycan, a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids; also called murein. An example of this component is found in Escherichia coli." [GOC:mlg, ISBN:0815108893]
subset: gosubset_prok
synonym: "envelope" BROAD []
synonym: "murein sacculus" RELATED []
synonym: "peptidoglycan" NARROW []
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0009275
name: Gram-positive-bacterium-type cell wall
namespace: cellular_component
def: "A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (20-80nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. Examples of this component are found in Gram-positive bacteria." [GOC:mlg, ISBN:0051406910, ISBN:0815108893]
subset: gosubset_prok
synonym: "20-80nm peptidoglycan-based cell wall" EXACT []
synonym: "cell wall of Gram-positive Bacteria" EXACT []
is_a: GO:0009274 ! peptidoglycan-based cell wall

[Term]
id: GO:0009276
name: Gram-negative-bacterium-type cell wall
namespace: cellular_component
def: "The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain." [GOC:mlg, ISBN:0815108893]
subset: gosubset_prok
synonym: "1-2nm peptidoglycan-based cell wall" EXACT []
synonym: "cell wall inner membrane" EXACT []
is_a: GO:0009274 ! peptidoglycan-based cell wall
relationship: part_of GO:0030313 ! cell envelope

[Term]
id: GO:0009277
name: fungal-type cell wall
namespace: cellular_component
def: "A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure." [GOC:mcc, GOC:mtg_sensu, ISBN:3540601864, PMID:11283274, PMID:16927300, PMID:3319422]
synonym: "beta-glucan-containing cell wall" RELATED []
synonym: "chitin- and beta-glucan-containing cell wall" NARROW []
synonym: "chitin-containing cell wall" RELATED []
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0009278
name: murein sacculus
namespace: cellular_component
def: "OBSOLETE. A peptidoglycan polymer that forms the shape-determining structure of the cell all of Gram-negative bacteria." [GOC:ma]
comment: This term was made obsolete because it was defined inaccurately.
is_obsolete: true
consider: GO:0009276

[Term]
id: GO:0009279
name: cell outer membrane
namespace: cellular_component
def: "A lipid bilayer that forms the outermost layer of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:mtg_sensu, ISBN:0135712254]
subset: gosubset_prok
synonym: "outer membrane of cell" EXACT []
is_a: GO:0019867 ! outer membrane
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0030313 ! cell envelope

[Term]
id: GO:0009280
name: cell wall inner membrane
namespace: cellular_component
def: "OBSOLETE. In Gram-negative bacteria the membrane that separates the cytoplasm from the murein sacculus." [GOC:ma]
comment: This term was made obsolete because it was defined inaccurately.
synonym: "cytoplasmic membrane" BROAD []
is_obsolete: true
consider: GO:0009276

[Term]
id: GO:0009288
name: bacterial-type flagellum
namespace: cellular_component
def: "A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:jh2, GOC:mtg_sensu, PMID:7787060]
subset: gosubset_prok
synonym: "flagellin-based flagellum" EXACT []
is_a: GO:0019861 ! flagellum
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0009289
name: pilus
namespace: cellular_component
def: "A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter." [GOC:pamgo_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "fimbria" EXACT []
synonym: "fimbriae" EXACT []
synonym: "fimbrium" EXACT []
synonym: "pili" EXACT []
xref: Wikipedia:Pilus
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0009290
name: DNA import into cell during transformation
namespace: biological_process
def: "The directed movement of DNA into a cell during the process of transformation, the uptake of foreign genetic material into a cell." [GOC:ai]
subset: gosubset_prok
synonym: "cellular DNA import during transformation" EXACT []
synonym: "cellular DNA uptake" BROAD []
synonym: "DNA import into cell" BROAD []
synonym: "DNA transport into cell during transformation" EXACT []
is_a: GO:0051027 ! DNA transport
relationship: part_of GO:0009294 ! DNA mediated transformation

[Term]
id: GO:0009291
name: unidirectional conjugation
namespace: biological_process
def: "The process of unidirectional (polarized) transfer of genetic information involving direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types. Examples of this process are found in Prokaryotes." [ISBN:0387520546]
subset: gosubset_prok
synonym: "mating" BROAD []
is_a: GO:0000746 ! conjugation
is_a: GO:0009292 ! genetic transfer

[Term]
id: GO:0009292
name: genetic transfer
namespace: biological_process
def: "In the absence of a sexual life cycle, the process involved in the introduction of genetic information to create a genetically different individual." [GOC:clt]
subset: goslim_pir
subset: gosubset_prok
synonym: "genetic exchange" BROAD []
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0009293
name: transduction
namespace: biological_process
def: "The transfer of genetic information to a bacterium from a bacteriophage or between bacterial or yeast cells mediated by a phage vector." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: Wikipedia:Transduction_(genetics)
is_a: GO:0009292 ! genetic transfer

[Term]
id: GO:0009294
name: DNA mediated transformation
namespace: biological_process
def: "The introduction and uptake of foreign genetic material (DNA or RNA) into a cell, and often the expression of that genetic material." [Wikipedia:Transformation_(genetics)]
subset: gosubset_prok
synonym: "DNA-mediated transformation" EXACT []
is_a: GO:0009292 ! genetic transfer

[Term]
id: GO:0009295
name: nucleoid
namespace: cellular_component
def: "The region of a bacterial cell, mitochondrion or chloroplast to which the DNA is confined." [GOC:ma, ISBN:3540076689]
subset: gosubset_prok
xref: Wikipedia:Nucleoid
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0009296
name: flagellum assembly
namespace: biological_process
def: "The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "flagella assembly" EXACT [GOC:mah]
synonym: "flagella biogenesis" RELATED []
synonym: "flagellum biogenesis" RELATED [GOC:mah]
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0043064 ! flagellum organization

[Term]
id: GO:0009297
name: pilus assembly
namespace: biological_process
def: "The assembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles." [GOC:dgh, GOC:mcc2, GOC:tb]
subset: gosubset_prok
synonym: "fimbria assembly" NARROW []
synonym: "fimbria biogenesis" RELATED []
synonym: "fimbriae assembly" NARROW []
synonym: "fimbriae biogenesis" RELATED []
synonym: "fimbrial assembly" NARROW []
synonym: "fimbrial biogenesis" NARROW []
synonym: "fimbrium assembly" NARROW []
synonym: "fimbrium biogenesis" RELATED []
synonym: "pili biosynthesis" EXACT []
synonym: "pili biosynthetic process" EXACT []
synonym: "pilus biogenesis" RELATED []
synonym: "pilus biosynthesis" EXACT []
synonym: "pilus formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0043711 ! pilus organization

[Term]
id: GO:0009298
name: GDP-mannose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP-mannose anabolism" EXACT []
synonym: "GDP-mannose biosynthesis" EXACT []
synonym: "GDP-mannose formation" EXACT []
synonym: "GDP-mannose synthesis" EXACT []
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0019307 ! mannose biosynthetic process
is_a: GO:0019673 ! GDP-mannose metabolic process

[Term]
id: GO:0009299
name: mRNA transcription
namespace: biological_process
alt_id: GO:0061023
def: "The cellular synthesis of messenger RNA (mRNA) from a DNA template." [GOC:jl]
subset: gosubset_prok
synonym: "cellular mRNA transcription" EXACT []
synonym: "mRNA biosynthesis" BROAD []
synonym: "mRNA biosynthetic process" BROAD []
synonym: "mRNA synthesis" BROAD []
is_a: GO:0006351 ! transcription, DNA-dependent

[Term]
id: GO:0009300
name: antisense RNA transcription
namespace: biological_process
def: "The synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0006351 ! transcription, DNA-dependent
is_a: GO:0042868 ! antisense RNA metabolic process

[Term]
id: GO:0009301
name: snRNA transcription
namespace: biological_process
def: "The synthesis of small nuclear RNA (snRNA) from a DNA template." [GOC:jl, ISBN:0321000382]
is_a: GO:0006351 ! transcription, DNA-dependent

[Term]
id: GO:0009302
name: snoRNA transcription
namespace: biological_process
def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template." [GOC:jl]
is_a: GO:0006351 ! transcription, DNA-dependent
is_a: GO:0016074 ! snoRNA metabolic process

[Term]
id: GO:0009303
name: rRNA transcription
namespace: biological_process
def: "The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "rRNA biosynthesis" BROAD []
synonym: "rRNA biosynthetic process" BROAD []
synonym: "rRNA synthesis" BROAD []
is_a: GO:0006351 ! transcription, DNA-dependent

[Term]
id: GO:0009304
name: tRNA transcription
namespace: biological_process
def: "The synthesis of transfer RNA (tRNA) from a DNA template." [GOC:jl]
subset: gosubset_prok
synonym: "tRNA biosynthesis" BROAD []
synonym: "tRNA biosynthetic process" BROAD []
synonym: "tRNA synthesis" BROAD []
is_a: GO:0006351 ! transcription, DNA-dependent

[Term]
id: GO:0009305
name: protein amino acid biotinylation
namespace: biological_process
def: "The addition of biotin (vitamin B7 / vitamin H) to a protein amino acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0009306
name: protein secretion
namespace: biological_process
alt_id: GO:0045166
alt_id: GO:0045731
def: "The controlled release of proteins from a cell or group of cells." [GOC:ai]
subset: gosubset_prok
synonym: "glycoprotein secretion" NARROW []
synonym: "protein secretion during cell fate commitment" NARROW []
synonym: "protein secretion resulting in cell fate commitment" NARROW []
is_a: GO:0015031 ! protein transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0009307
name: DNA restriction-modification system
namespace: biological_process
def: "Any process that protect an organism from invading foreign DNA by methylation of self DNA at specific sequences and nucleolytic cleavage of unmethylated foreign DNA." [GOC:mah]
subset: gosubset_prok
synonym: "DNA restriction" BROAD []
is_a: GO:0006304 ! DNA modification

[Term]
id: GO:0009308
name: amine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
synonym: "amine metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0009309
name: amine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "amine anabolism" EXACT []
synonym: "amine biosynthesis" EXACT []
synonym: "amine formation" EXACT []
synonym: "amine synthesis" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process

[Term]
id: GO:0009310
name: amine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "amine breakdown" EXACT []
synonym: "amine catabolism" EXACT []
synonym: "amine degradation" EXACT []
is_a: GO:0009308 ! amine metabolic process

[Term]
id: GO:0009311
name: oligosaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "oligosaccharide metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process

[Term]
id: GO:0009312
name: oligosaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "oligosaccharide anabolism" EXACT []
synonym: "oligosaccharide biosynthesis" EXACT []
synonym: "oligosaccharide formation" EXACT []
synonym: "oligosaccharide synthesis" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0016051 ! carbohydrate biosynthetic process

[Term]
id: GO:0009313
name: oligosaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "oligosaccharide breakdown" EXACT []
synonym: "oligosaccharide catabolism" EXACT []
synonym: "oligosaccharide degradation" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0016052 ! carbohydrate catabolic process

[Term]
id: GO:0009314
name: response to radiation
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation]
comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength.
subset: gosubset_prok
synonym: "response to electromagnetic radiation stimulus" EXACT []
synonym: "response to radiation stimulus" EXACT []
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009315
name: drug resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0042493

[Term]
id: GO:0009316
name: 3-isopropylmalate dehydratase complex
namespace: cellular_component
def: "A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate." [BRENDA:4.2.1.33, GOC:jl, MetaCyc:3-ISOPROPYLMALISOM-CPLX, PMID:7026530]
comment: See also the molecular function term '3-isopropylmalate dehydratase activity ; GO:0003861'.
subset: gosubset_prok
synonym: "isopropylmalate isomerase complex" EXACT []
xref: MetaCyc:3-ISOPROPYLMALISOM-CPLX
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0009317
name: acetyl-CoA carboxylase complex
namespace: cellular_component
def: "A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex." [GOC:jl, GOC:mah, PMID:12121720]
subset: goslim_pir
subset: gosubset_prok
synonym: "ACCase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009318
name: exodeoxyribonuclease VII complex
namespace: cellular_component
def: "An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA." [EC:3.1.11.6]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009319
name: cytochrome o ubiquinol oxidase complex
namespace: cellular_component
def: "A protein complex that possesses cytochrome o ubiquinol oxidase activity; consists of four polypeptide subunits and associated prosthetic groups." [GOC:mah, MetaCyc:CYT-O-UBIOX-CPLX, PMID:11017202, PMID:3052268]
comment: See also the molecular function term 'cytochrome o ubiquinol oxidase activity ; GO:0008827'.
subset: gosubset_prok
xref: MetaCyc:CYT-O-UBIOX-CPLX
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0016021 ! integral to membrane

[Term]
id: GO:0009320
name: phosphoribosylaminoimidazole carboxylase complex
namespace: cellular_component
def: "A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity." [GOC:mah]
comment: See also the molecular function term 'phosphoribosylaminoimidazole carboxylase activity ; GO:0004638'.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009321
name: alkyl hydroperoxide reductase complex
namespace: cellular_component
def: "An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides." [BRENDA:1.11.1.15, GOC:jl, PMID:2649484]
comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009322
name: trimethylamine-N-oxide reductase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine." [EC:1.6.6.9]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009323
name: ribosomal-protein-alanine N-acetyltransferase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine." [EC:2.3.1.128]
is_a: GO:0031248 ! protein acetyltransferase complex

[Term]
id: GO:0009324
name: D-amino-acid dehydrogenase complex
namespace: cellular_component
def: "A protein complex that possesses D-amino-acid dehydrogenase activity." [GOC:mah]
comment: See also the molecular function term 'D-amino-acid oxidase activity ; GO:0003884'.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0009325
name: nitrate reductase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor." [EC:1.7.99.4]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009326
name: formate dehydrogenase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2)." [EC:1.2.1.2]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009327
name: NAD(P)+ transhydrogenase complex (AB-specific)
namespace: cellular_component
def: "A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified." [BRENDA:1.6.1.2, GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009328
name: phenylalanine-tRNA ligase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009329
name: acetate CoA-transferase complex
namespace: cellular_component
def: "A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA." [GOC:jl, PMID:2719476, PMID:8423010]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex

[Term]
id: GO:0009330
name: DNA topoisomerase complex (ATP-hydrolyzing)
namespace: cellular_component
def: "Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah]
comment: See also the molecular function term 'DNA topoisomerase (ATP-hydrolyzing) activity ; GO:0003918'.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009331
name: glycerol-3-phosphate dehydrogenase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.99.5]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009332
name: glutamate-tRNA ligase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu)." [EC:6.1.1.17]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009333
name: cysteine synthase complex
namespace: cellular_component
def: "Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A." [EC:4.2.99.8, MetaCyc:CYSSYNMULTI-CPLX]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009334
name: 3-phenylpropionate dioxygenase complex
namespace: cellular_component
def: "Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol)." [GOC:jl, MetaCyc:HCAMULTI-CPLX, PMID:9603882]
comment: See also the molecular function term '3-phenylpropionate dioxygenase activity ; GO:0008695'.
xref: MetaCyc:HCAMULTI-CPLX
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009335
name: holo-[acyl-carrier protein] synthase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the formation of holo-[acyl-carrier protein] from CoA and apo-[acyl-carrier protein]." [EC:2.7.8.7]
comment: This term was made obsolete because the catalytic activity resides in a single polypeptide rather than a complex, and the complex is represented by a different GO term.
synonym: "holo-ACP synthase complex" EXACT []
is_obsolete: true
consider: GO:0005835

[Term]
id: GO:0009336
name: sulfate adenylyltransferase complex (ATP)
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP." [EC:2.7.7.4]
synonym: "sulphate adenylyltransferase complex (ATP)" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009337
name: sulfite reductase complex (NADPH)
namespace: cellular_component
def: "A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide." [BRENDA:1.8.1.2, GOC:jl]
comment: See also the molecular function term 'sulfite reductase (NADPH) activity ; GO:0004783'.
subset: gosubset_prok
synonym: "sulphite reductase complex (NADPH)" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009338
name: exodeoxyribonuclease V complex
namespace: cellular_component
def: "An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA." [EC:3.1.11.5]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009339
name: glycolate oxidase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN)." [EC:1.1.3.15]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009340
name: DNA topoisomerase IV complex
namespace: cellular_component
def: "A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA." [GOC:jl, PMID:7783632]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009341
name: beta-galactosidase complex
namespace: cellular_component
def: "A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23, PMID:15950161]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0009342
name: glutamate synthase complex (NADPH)
namespace: cellular_component
def: "A complex that possesses glutamate synthase (NADPH) activity." [EC:1.4.1.13, GOC:mah]
subset: gosubset_prok
is_a: GO:0031026 ! glutamate synthase complex

[Term]
id: GO:0009343
name: biotin carboxylase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2)." [EC:6.3.4.14]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex

[Term]
id: GO:0009344
name: nitrite reductase complex [NAD(P)H]
namespace: cellular_component
def: "Complex that possesses nitrite reductase [NAD(P)H] activity." [GOC:mah]
comment: See also the molecular function term 'nitrite reductase [NAD(P)H] activity ; GO:0008942'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009345
name: glycine-tRNA ligase complex
namespace: cellular_component
def: "A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly)." [EC:6.1.1.14, GOC:jl, PMID:15733854]
subset: gosubset_prok
synonym: "glycine-tRNA synthetase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009346
name: citrate lyase complex
namespace: cellular_component
def: "Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity." [EC:4.1.3.6, MetaCyc:ACECITLY-CPLX]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009347
name: aspartate carbamoyltransferase complex
namespace: cellular_component
def: "A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides." [PMID:10447693]
comment: Note that in eukaryotes, aspartate carbamoyltransferase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009348
name: ornithine carbamoyltransferase complex
namespace: cellular_component
def: "A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline." [EC:2.1.3.3, GOC:mah]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009349
name: riboflavin synthase complex
namespace: cellular_component
def: "An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine." [EC:2.5.1.9]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009350
name: ethanolamine ammonia-lyase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia." [EC:4.3.1.7]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009351
name: dihydrolipoamide S-acyltransferase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the transfer of an acyl group from coenzyme A to dihydrolipoamide." [EC:2.3.1.12]
comment: This term was made obsolete because dihydrolipoamide S-acyltransferase activity resides in a single polypeptide.
is_obsolete: true

[Term]
id: GO:0009352
name: dihydrolipoyl dehydrogenase complex
namespace: cellular_component
def: "OBSOLETE. Complex that possesses dihydrolipoyl dehydrogenase activity." [GOC:mah]
comment: This term was made obsolete because the activity dihydrolipoamide dehydrogenase is held by a single protein (Lpd1 in yeast), which is one of the components of three different complexes: 2-oxoglutarate dehydrogenase, pyruvate dehydrogenase, and branch chain amino acid dehydrogenase, so dihydrolipoamide dehydrogenase is not a complex itself.
synonym: "dihydrolipoamide dehydrogenase complex" EXACT []
is_obsolete: true
consider: GO:0004148
consider: GO:0045240
consider: GO:0045254

[Term]
id: GO:0009353
name: mitochondrial oxoglutarate dehydrogenase complex
namespace: cellular_component
def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus." [GOC:mtg_sensu, MetaCyc:CPLX66-42, PMID:10848975]
comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'.
is_a: GO:0044429 ! mitochondrial part
is_a: GO:0045252 ! oxoglutarate dehydrogenase complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0009354
name: dihydrolipoamide S-succinyltransferase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the transfer of succinyl-CoA to dihydrolipoamide to form S-succinyldihydrolipoamide. The enzyme is a component of the multienzyme 2-oxoglutarate dehydrogenase complex." [EC:2.3.1.61]
comment: This term was made obsolete because dihydrolipoamide S-succinyltransferase itself is not a complex, it is a component of the 2-oxoglutarate dehydrogenase complex, the activity dihydrolipoamide S-succinyltransferase is contained in a single polypeptide.
is_obsolete: true
consider: GO:0045252

[Term]
id: GO:0009355
name: DNA polymerase V complex
namespace: cellular_component
def: "A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis." [PMID:10430871, PMID:10542196]
is_a: GO:0042575 ! DNA polymerase complex

[Term]
id: GO:0009356
name: aminodeoxychorismate synthase complex
namespace: cellular_component
def: "A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity." [PMID:2251281, PMID:7592344]
synonym: "4-amino-4-deoxychorismate synthase complex" RELATED []
synonym: "ADC synthase complex" EXACT []
synonym: "p-aminobenzoate synthetase complex" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009357
name: protein-N(PI)-phosphohistidine-sugar phosphotransferase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system." [EC:2.7.1.69]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009358
name: polyphosphate kinase complex
namespace: cellular_component
def: "A protein complex that possesses polyphosphate kinase activity." [GOC:mah]
comment: See also the molecular function term 'polyphosphate kinase activity ; GO:0008976'.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009359
name: Type II site-specific deoxyribonuclease complex
namespace: cellular_component
def: "A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995]
subset: gosubset_prok
synonym: "Type II restriction enzyme complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009360
name: DNA polymerase III complex
namespace: cellular_component
def: "A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands." [PMID:11525729, PMID:12940977]
subset: gosubset_prok
is_a: GO:0042575 ! DNA polymerase complex

[Term]
id: GO:0009361
name: succinate-CoA ligase complex (ADP-forming)
namespace: cellular_component
def: "A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP." [EC:6.2.1.5, GOC:jl]
subset: gosubset_prok
synonym: "succinyl-CoA synthetase, ADP-forming" EXACT [CORUM:394]
is_a: GO:0042709 ! succinate-CoA ligase complex

[Term]
id: GO:0009365
name: protein histidine kinase complex
namespace: cellular_component
def: "A complex that possesses protein histidine kinase activity." [GOC:mah]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0009366
name: enterobactin synthetase complex
namespace: cellular_component
def: "A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway." [MetaCyc:ENTMULTI-CPLX, PMID:9485415]
subset: gosubset_prok
synonym: "enterochelin synthetase complex" EXACT []
xref: MetaCyc:ENTMULTI-CPLX
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009367
name: prepilin peptidase complex
namespace: cellular_component
def: "OBSOLETE. An enzyme complex that catalyzes the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group." [EC:3.4.23.43]
comment: This term was made obsolete because prepilin peptidase is a single gene product, and there is no evidence that it acts as a multimer.
is_obsolete: true

[Term]
id: GO:0009368
name: endopeptidase Clp complex
namespace: cellular_component
def: "A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form." [GOC:mah, PMID:11352464]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009369
name: quorum sensing signal generator activity
namespace: molecular_function
subset: gosubset_prok
is_a: GO:0004871 ! signal transducer activity

[Term]
id: GO:0009370
name: quorum sensing response regulator activity
namespace: molecular_function
subset: gosubset_prok
is_a: GO:0004871 ! signal transducer activity

[Term]
id: GO:0009371
name: positive regulation of transcription by pheromones
namespace: biological_process
def: "Any process involving pheromones that activates or increases the rate of transcription." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of transcription by pheromones" NARROW []
synonym: "stimulation of transcription by pheromones" NARROW []
synonym: "up regulation of transcription by pheromones" EXACT []
synonym: "up-regulation of transcription by pheromones" EXACT []
synonym: "upregulation of transcription by pheromones" EXACT []
is_a: GO:0009373 ! regulation of transcription by pheromones
is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent

[Term]
id: GO:0009372
name: quorum sensing
namespace: biological_process
def: "The process by which single-celled organisms monitor their population density by detecting the concentration of small, diffusible signal molecules produced by the cells themselves." [PMID:15716452, PMID:8288518]
subset: goslim_pir
subset: gosubset_prok
synonym: "quorum sensing system" EXACT []
xref: Wikipedia:Quorum_sensing
is_a: GO:0048874 ! homeostasis of number of cells in a free-living population

[Term]
id: GO:0009373
name: regulation of transcription by pheromones
namespace: biological_process
def: "Any process involving pheromones that modulates the frequency, rate or extent of transcription." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006355 ! regulation of transcription, DNA-dependent
is_a: GO:0071444 ! cellular response to pheromone

[Term]
id: GO:0009374
name: biotin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "vitamin B7 binding" EXACT []
synonym: "vitamin H binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0033293 ! monocarboxylic acid binding

[Term]
id: GO:0009375
name: ferredoxin hydrogenase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances." [EC:1.12.7.2]
subset: gosubset_prok
synonym: "hydrogenase complex" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009376
name: HslUV protease complex
namespace: cellular_component
def: "A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other Clp family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, six identical subunits of both the ATPase, ClpY, and the protease, ClpQ, self-assemble into an oligomeric ring, and two rings of each subunit, two ClpQ rings surrounded by single ClpY rings, form a dumbbell-shaped complex." [PMID:12670962]
subset: gosubset_prok
synonym: "ClpYQ protease complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009377
name: HslUV protease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins." [GOC:mah, PMID:10368141]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
is_obsolete: true
replaced_by: GO:0070011

[Term]
id: GO:0009378
name: four-way junction helicase activity
namespace: molecular_function
def: "Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions." [GOC:jl, PMID:9442895]
subset: gosubset_prok
synonym: "Holliday junction helicase activity" NARROW []
is_a: GO:0003678 ! DNA helicase activity

[Term]
id: GO:0009379
name: Holliday junction helicase complex
namespace: cellular_component
def: "A DNA helicase complex that forms part of a Holliday junction resolvase complex, where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA ." [PMID:16935884, PMID:9442895]
subset: gosubset_prok
is_a: GO:0033202 ! DNA helicase complex
relationship: part_of GO:0048476 ! Holliday junction resolvase complex

[Term]
id: GO:0009380
name: excinuclease repair complex
namespace: cellular_component
def: "Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and one B subunit bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between subunit B and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap." [GOC:mah, GOC:mlg, PMID:15192705]
subset: gosubset_prok
synonym: "excinuclease ABC complex" EXACT []
synonym: "UvrABC excinuclease complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009381
name: excinuclease ABC activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind." [GOC:mah, PMID:15192705]
subset: gosubset_prok
is_a: GO:0004520 ! endodeoxyribonuclease activity

[Term]
id: GO:0009382
name: imidazoleglycerol-phosphate synthase complex
namespace: cellular_component
def: "Complex that possesses imidazoleglycerol-phosphate synthase activity." [GOC:mah]
comment: See also the molecular function term 'imidazoleglycerol-phosphate synthase activity ; GO:0000107'.
subset: gosubset_prok
synonym: "imidazoleglycerol phosphate synthase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009383
name: rRNA (cytosine-C5-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA." [GOC:imk, PMID:10026269, PMID:18786544]
synonym: "rRNA (cytosine-C5-967)-methyltransferase activity" NARROW []
synonym: "rRNA m5C967 methyltransferase activity" NARROW []
xref: EC:2.1.1.-
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity

[Term]
id: GO:0009384
name: N-acylmannosamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate." [EC:2.7.1.60]
subset: gosubset_prok
synonym: "acetylamidodeoxymannokinase activity" EXACT [EC:2.7.1.60]
synonym: "acetylmannosamine kinase activity" EXACT [EC:2.7.1.60]
synonym: "acylaminodeoxymannokinase activity" EXACT [EC:2.7.1.60]
synonym: "acylmannosamine kinase (phosphorylating)" EXACT [EC:2.7.1.60]
synonym: "acylmannosamine kinase activity" EXACT [EC:2.7.1.60]
synonym: "ATP:N-acetylmannosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.60]
synonym: "ATP:N-acyl-D-mannosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.60]
synonym: "N-acetylmannosamine kinase activity" EXACT [EC:2.7.1.60]
synonym: "N-acyl-D-mannosamine kinase activity" EXACT [EC:2.7.1.60]
xref: EC:2.7.1.60
xref: MetaCyc:N-ACYLMANNOSAMINE-KINASE-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0009385
name: N-acylmannosamine-6-phosphate 2-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate." [MetaCyc:NANE-RXN]
synonym: "N-acylmannosamine-6-P epimerase activity" EXACT []
xref: EC:5.-.-.-
xref: MetaCyc:NANE-RXN
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0009386
name: translational attenuation
namespace: biological_process
def: "Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation." [PMID:15694341, PMID:15805513]
subset: gosubset_prok
is_a: GO:0006417 ! regulation of translation

[Term]
id: GO:0009388
name: antisense RNA
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true

[Term]
id: GO:0009389
name: dimethyl sulfoxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O." [UM-BBD_enzymeID:e0188]
subset: gosubset_prok
synonym: "dimethyl sulphoxide reductase activity" EXACT []
xref: EC:1.8.99.-
xref: UM-BBD_enzymeID:e0188
is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors

[Term]
id: GO:0009390
name: dimethyl sulfoxide reductase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide." [UM-BBD_enzymeID:e0188]
synonym: "dimethyl sulphoxide reductase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009391
name: ribonucleotide reductase activating enzyme activity
namespace: molecular_function
xref: EC:1.97.1.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0009392
name: N-acetyl-anhydromuramoyl-L-alanine amidase activity
namespace: molecular_function
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0009394
name: 2'-deoxyribonucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:mah]
subset: gosubset_prok
synonym: "2'-deoxyribonucleotide metabolism" EXACT []
is_a: GO:0009262 ! deoxyribonucleotide metabolic process

[Term]
id: GO:0009395
name: phospholipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phospholipid breakdown" EXACT []
synonym: "phospholipid catabolism" EXACT []
synonym: "phospholipid degradation" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0044242 ! cellular lipid catabolic process

[Term]
id: GO:0009396
name: folic acid and derivative biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai]
subset: gosubset_prok
synonym: "folate and derivative biosynthesis" EXACT []
synonym: "folate and derivative biosynthetic process" EXACT []
synonym: "folic acid and derivative anabolism" EXACT []
synonym: "folic acid and derivative biosynthesis" EXACT []
synonym: "folic acid and derivative formation" EXACT []
synonym: "folic acid and derivative synthesis" EXACT []
synonym: "vitamin B9 and derivative biosynthesis" EXACT []
synonym: "vitamin B9 and derivative biosynthetic process" EXACT []
synonym: "vitamin M and derivative biosynthesis" EXACT []
synonym: "vitamin M and derivative biosynthetic process" EXACT []
is_a: GO:0006760 ! folic acid and derivative metabolic process
is_a: GO:0009108 ! coenzyme biosynthetic process

[Term]
id: GO:0009397
name: folic acid and derivative catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of folic acid and its derivatives." [GOC:ai]
subset: gosubset_prok
synonym: "folate and derivative catabolic process" EXACT []
synonym: "folate and derivative catabolism" EXACT []
synonym: "folic acid and derivative breakdown" EXACT []
synonym: "folic acid and derivative catabolism" EXACT []
synonym: "folic acid and derivative degradation" EXACT []
synonym: "vitamin B9 and derivative catabolic process" EXACT []
synonym: "vitamin B9 and derivative catabolism" EXACT []
synonym: "vitamin M and derivative catabolic process" EXACT []
synonym: "vitamin M and derivative catabolism" EXACT []
is_a: GO:0006760 ! folic acid and derivative metabolic process
is_a: GO:0009109 ! coenzyme catabolic process

[Term]
id: GO:0009398
name: FMN biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:ai, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "FMN anabolism" EXACT []
synonym: "FMN biosynthesis" EXACT []
synonym: "FMN formation" EXACT []
synonym: "FMN synthesis" EXACT []
is_a: GO:0006746 ! FADH2 metabolic process
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process
is_a: GO:0042727 ! riboflavin and derivative biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0046444 ! FMN metabolic process

[Term]
id: GO:0009399
name: nitrogen fixation
namespace: biological_process
def: "The process by which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide." [Wikipedia:Nitrogen_fixation]
subset: gosubset_prok
xref: MetaCyc:N2FIX-PWY
xref: Wikipedia:Nitrogen_fixation
is_a: GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0009400
name: receptor signaling protein serine/threonine phosphatase activity
namespace: molecular_function
synonym: "receptor signalling protein serine/threonine phosphatase activity" EXACT []
is_a: GO:0004722 ! protein serine/threonine phosphatase activity
is_a: GO:0005057 ! receptor signaling protein activity

[Term]
id: GO:0009401
name: phosphoenolpyruvate-dependent sugar phosphotransferase system
namespace: biological_process
def: "The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html]
subset: gosubset_prok
synonym: "PTS system" NARROW []
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0009402
name: toxin resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0009636

[Term]
id: GO:0009403
name: toxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators]
subset: gosubset_prok
synonym: "toxin anabolism" EXACT []
synonym: "toxin biosynthesis" EXACT []
synonym: "toxin formation" EXACT []
synonym: "toxin synthesis" EXACT []
is_a: GO:0009404 ! toxin metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0009404
name: toxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:cab2]
subset: goslim_pir
subset: gosubset_prok
synonym: "toxin metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0009405
name: pathogenesis
namespace: biological_process
def: "The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators]
comment: Note that this term should not be used to annotate gene products that are involved in the host response to pathogenesis. It should only be used to annotate those gene products involved in the generation of pathogenesis by the pathogen itself.
subset: goslim_candida
subset: goslim_goa
subset: gosubset_prok
synonym: "channel-forming toxin activity" RELATED []
synonym: "cytotoxin activity" RELATED []
synonym: "endotoxin activity" RELATED []
synonym: "enterotoxin activity" RELATED []
synonym: "exotoxin activity" RELATED []
synonym: "lipoprotein toxin" RELATED []
synonym: "neurotoxin activity" RELATED []
synonym: "pore-forming toxin activity" RELATED []
synonym: "toxin activity" RELATED []
synonym: "virulence" RELATED []
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0009406
name: virulence
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a phenotype rather than a biological process.
is_obsolete: true
consider: GO:0009405
consider: GO:0016032

[Term]
id: GO:0009407
name: toxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators]
subset: gosubset_prok
synonym: "toxin breakdown" EXACT []
synonym: "toxin catabolism" EXACT []
synonym: "toxin degradation" EXACT []
is_a: GO:0009404 ! toxin metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0009408
name: response to heat
namespace: biological_process
alt_id: GO:0006951
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr]
subset: gosubset_prok
synonym: "response to heat shock" NARROW []
is_a: GO:0006950 ! response to stress
is_a: GO:0009266 ! response to temperature stimulus

[Term]
id: GO:0009409
name: response to cold
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr]
subset: gosubset_prok
synonym: "freezing tolerance" RELATED []
is_a: GO:0006950 ! response to stress
is_a: GO:0009266 ! response to temperature stimulus

[Term]
id: GO:0009410
name: response to xenobiotic stimulus
namespace: biological_process
alt_id: GO:0017104
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms." [GOC:jl]
subset: gosubset_prok
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0009411
name: response to UV
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb]
subset: gosubset_prok
synonym: "response to ultraviolet light stimulus" EXACT []
synonym: "response to ultraviolet radiation stimulus" EXACT []
synonym: "response to UV light stimulus" EXACT []
synonym: "response to UV radiation stimulus" EXACT []
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0009412
name: response to heavy metal
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heavy metal stimulus. Heavy metals are those metals that can form a coordination bond with a protein; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
is_obsolete: true
consider: GO:0010038

[Term]
id: GO:0009413
name: response to flooding
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating flooding, short-term immersion in water." [GOC:lr]
comment: Note that this term should not be confused with 'response to deep water ; GO:0030912'. Flooding refers to short-term immersion, whereas 'response to deep water ; GO:0030912' refers to standing in water throughout an organism's life cycle.
is_a: GO:0006950 ! response to stress
is_a: GO:0009415 ! response to water

[Term]
id: GO:0009414
name: response to water deprivation
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [GOC:lr]
subset: gosubset_prok
synonym: "drought tolerance" RELATED []
synonym: "response to dehydration" EXACT []
synonym: "response to drought" EXACT []
synonym: "response to thirst" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0009415 ! response to water

[Term]
id: GO:0009415
name: response to water
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus." [GOC:jl]
subset: gosubset_prok
is_a: GO:0009628 ! response to abiotic stimulus
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0009416
name: response to light stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089]
subset: gosubset_prok
is_a: GO:0009314 ! response to radiation

[Term]
id: GO:0009417
name: fimbrin
namespace: cellular_component
def: "OBSOLETE. A class of proteins that are the subunit components of fimbria." [ISBN:0914826859]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
replaced_by: GO:0009289

[Term]
id: GO:0009418
name: pilus shaft
namespace: cellular_component
def: "The long, slender, mid section of a pilus." [GOC:jl]
subset: gosubset_prok
synonym: "fimbrial shaft" EXACT []
is_a: GO:0044443 ! pilus part

[Term]
id: GO:0009419
name: pilus tip
namespace: cellular_component
def: "The pointed extremity furthest from the cell of a pilus." [GOC:jl]
subset: gosubset_prok
synonym: "fimbrial tip" EXACT []
is_a: GO:0044443 ! pilus part

[Term]
id: GO:0009420
name: bacterial-type flagellum filament
namespace: cellular_component
def: "The long (approximately 20 nm), thin external structure of the flagellum, which acts as a propeller. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar filament" EXACT []
synonym: "flagellin-based flagellum filament" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part

[Term]
id: GO:0009421
name: bacterial-type flagellum filament cap
namespace: cellular_component
def: "The proteinaceous structure at the distal tip of the flagellar filament. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar filament cap" EXACT []
synonym: "flagellin-based flagellum filament cap" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part
relationship: part_of GO:0009420 ! bacterial-type flagellum filament

[Term]
id: GO:0009422
name: bacterial-type flagellum hook-filament junction
namespace: cellular_component
def: "The region of the flagellum where the hook and filament meet. Examples of this component are found in bacteria." [GOC:mah, GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar hook-filament junction" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part

[Term]
id: GO:0009423
name: chorismate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds." [GOC:sm, ISBN:0198547684]
subset: gosubset_prok
synonym: "chorismate anabolism" EXACT []
synonym: "chorismate biosynthesis" EXACT []
synonym: "chorismate formation" EXACT []
synonym: "chorismate synthesis" EXACT []
xref: MetaCyc:ARO-PWY
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process
is_a: GO:0046417 ! chorismate metabolic process

[Term]
id: GO:0009424
name: bacterial-type flagellum hook
namespace: cellular_component
def: "The portion of the flagellum that connects the filament to the basal body. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar hook" EXACT []
synonym: "flagellin-based flagellum hook" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part

[Term]
id: GO:0009425
name: bacterial-type flagellum basal body
namespace: cellular_component
def: "One of the three major substructures of the flagellin-based flagellum; a structure consisting of a rod, a series of rings, the Mot proteins, the switch complex and the flagellum-specific export apparatus. The rings anchor the flagellum to the cytoplasmic membrane (MS ring), the peptidoglycan (P ring) and the outer membrane (L ring). Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar basal body" BROAD []
synonym: "flagellin-based flagellum basal body" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part

[Term]
id: GO:0009426
name: bacterial-type flagellum basal body, distal rod
namespace: cellular_component
def: "The portion of the central rod of the flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar basal body, distal rod" EXACT []
synonym: "flagellin-based flagellum basal body, distal rod" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part
relationship: part_of GO:0030694 ! bacterial-type flagellum basal body, rod

[Term]
id: GO:0009427
name: bacterial-type flagellum basal body, distal rod, L ring
namespace: cellular_component
def: "One of the rings of the flagellar basal body; anchors the basal body to the outer membrane. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar basal body, distal rod, L ring" EXACT []
synonym: "flagellin-based flagellum basal body, distal rod, L ring" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part
relationship: part_of GO:0009426 ! bacterial-type flagellum basal body, distal rod

[Term]
id: GO:0009428
name: bacterial-type flagellum basal body, distal rod, P ring
namespace: cellular_component
def: "One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar basal body, distal rod, P ring" RELATED []
synonym: "flagellin-based flagellum basal body, distal rod, P ring" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part
relationship: part_of GO:0009426 ! bacterial-type flagellum basal body, distal rod

[Term]
id: GO:0009429
name: bacterial-type flagellum basal body, proximal rod
namespace: cellular_component
def: "The portion of the central rod of the flagellar basal body that is proximal to the cell membrane; proximal rod connects the distal rod to the flagellar motor. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar basal body, proximal rod" EXACT []
synonym: "flagellin-based flagellum basal body, proximal rod" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part
relationship: part_of GO:0030694 ! bacterial-type flagellum basal body, rod

[Term]
id: GO:0009431
name: bacterial-type flagellum basal body, MS ring
namespace: cellular_component
alt_id: GO:0009430
def: "One of the rings of the flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar basal body, mounting plate" BROAD []
synonym: "flagellar basal body, MS ring" EXACT []
synonym: "flagellin-based flagellum basal body, MS ring" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part
relationship: part_of GO:0009425 ! bacterial-type flagellum basal body

[Term]
id: GO:0009432
name: SOS response
namespace: biological_process
def: "An error-prone process for repairing damaged microbial DNA." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
xref: Wikipedia:SOS_response
is_a: GO:0031668 ! cellular response to extracellular stimulus
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0009433
name: bacterial-type flagellum basal body, C ring
namespace: cellular_component
def: "Cytoplasmic ring located at the base of the flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar basal body, C ring" EXACT []
synonym: "flagellin-based flagellum basal body, C ring" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part
relationship: part_of GO:0009425 ! bacterial-type flagellum basal body

[Term]
id: GO:0009434
name: microtubule-based flagellum
namespace: cellular_component
def: "A long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. The flagellum is based on a 9+2 arrangement of microtubules." [GOC:mtg_sensu, ISBN:0815316194]
comment: See also the cellular component term 'cilium ; GO:0005929'.
is_a: GO:0019861 ! flagellum
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0009435
name: NAD biosynthetic process
namespace: biological_process
alt_id: GO:0006736
def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]
subset: gosubset_prok
synonym: "NAD (oxidized) biosynthesis" EXACT []
synonym: "NAD (oxidized) biosynthetic process" EXACT []
synonym: "NAD (reduced) biosynthesis" EXACT []
synonym: "NAD (reduced) biosynthetic process" EXACT []
synonym: "NAD anabolism" EXACT []
synonym: "NAD biosynthesis" EXACT []
synonym: "NAD formation" EXACT []
synonym: "NAD synthesis" EXACT []
synonym: "NADH biosynthesis" EXACT []
synonym: "NADH biosynthetic process" EXACT []
synonym: "nicotinamide adenine dinucleotide biosynthesis" EXACT []
synonym: "nicotinamide adenine dinucleotide biosynthetic process" EXACT []
synonym: "oxidized NAD biosynthesis" EXACT []
synonym: "oxidized NAD biosynthetic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide biosynthesis" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide biosynthetic process" EXACT []
synonym: "reduced NAD biosynthesis" EXACT []
synonym: "reduced NAD biosynthetic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide biosynthesis" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide biosynthetic process" EXACT []
is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process
is_a: GO:0019674 ! NAD metabolic process

[Term]
id: GO:0009436
name: glyoxylate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glyoxylate breakdown" EXACT []
synonym: "glyoxylate catabolism" EXACT []
synonym: "glyoxylate degradation" EXACT []
xref: MetaCyc:GLYOXDEG-PWY
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0046487 ! glyoxylate metabolic process

[Term]
id: GO:0009437
name: carnitine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "carnitine metabolism" EXACT []
synonym: "vitamin Bt metabolic process" EXACT []
synonym: "vitamin Bt metabolism" EXACT []
is_a: GO:0006577 ! betaine metabolic process
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0009438
name: methylglyoxal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "methylglyoxal bypass" NARROW []
synonym: "methylglyoxal metabolism" EXACT []
synonym: "methylglyoxal pathway" NARROW []
xref: MetaCyc:METHGLYUT-PWY
is_a: GO:0006081 ! cellular aldehyde metabolic process

[Term]
id: GO:0009439
name: cyanate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cyanate metabolism" EXACT []
xref: MetaCyc:CYANCAT-PWY
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process

[Term]
id: GO:0009440
name: cyanate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cyanate breakdown" EXACT []
synonym: "cyanate catabolism" EXACT []
synonym: "cyanate degradation" EXACT []
is_a: GO:0009439 ! cyanate metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process

[Term]
id: GO:0009441
name: glycolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycolate metabolism" EXACT []
xref: MetaCyc:GLYCOLATEMET-PWY
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0009442
name: allantoin assimilation pathway
namespace: biological_process
def: "The pathways by which allantoin is processed and converted to ureidoglycolate, and then into metabolically useful substrates. E. coli are able to utilize allantoin as a sole nitrogen source under anaerobic conditions by converting it to ureidoglycolate; this may be further metabolized to produce glyoxylate and thence 3-phosphoglycerate, or alternatively oxidized to oxolureate, which can converted into oxamate and carbamoylphosphate. This may then be further metabolized to CO2, NH4+ and ATP." [MetaCyc:PWY0-41]
subset: gosubset_prok
synonym: "allantoin catabolic process via ureidoglycolate" EXACT []
synonym: "allantoin catabolism via ureidoglycolate" EXACT []
synonym: "allantoin degradation pathway" RELATED []
xref: MetaCyc:PWY0-41
is_a: GO:0000256 ! allantoin catabolic process

[Term]
id: GO:0009443
name: pyridoxal 5'-phosphate salvage
namespace: biological_process
def: "Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "pyridoxal 5' phosphate salvage" EXACT []
xref: MetaCyc:PLPSAL-PWY
is_a: GO:0008615 ! pyridoxine biosynthetic process
is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0009444
name: pyruvate oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of pyruvate to acetylphosphate." [MetaCyc:PYRUVOX-PWY]
subset: gosubset_prok
xref: MetaCyc:PYRUVOX-PWY
xref: Wikipedia:Pyruvate_decarboxylation
is_a: GO:0006090 ! pyruvate metabolic process

[Term]
id: GO:0009445
name: putrescine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine." [GOC:ai]
subset: gosubset_prok
synonym: "putrescine metabolism" EXACT []
is_a: GO:0006595 ! polyamine metabolic process

[Term]
id: GO:0009446
name: putrescine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "putrescine anabolism" EXACT []
synonym: "putrescine biosynthesis" EXACT []
synonym: "putrescine formation" EXACT []
synonym: "putrescine synthesis" EXACT []
is_a: GO:0006596 ! polyamine biosynthetic process
is_a: GO:0009445 ! putrescine metabolic process

[Term]
id: GO:0009447
name: putrescine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine." [GOC:ai]
subset: gosubset_prok
synonym: "putrescine breakdown" EXACT []
synonym: "putrescine catabolism" EXACT []
synonym: "putrescine degradation" EXACT []
is_a: GO:0006598 ! polyamine catabolic process
is_a: GO:0009445 ! putrescine metabolic process

[Term]
id: GO:0009448
name: gamma-aminobutyric acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: See also the biological process term 'neurotransmitter metabolic process ; GO:0042133'.
subset: gosubset_prok
synonym: "4-aminobutanoate metabolic process" EXACT []
synonym: "4-aminobutanoate metabolism" EXACT []
synonym: "4-aminobutyrate metabolic process" EXACT []
synonym: "4-aminobutyrate metabolism" EXACT []
synonym: "GABA metabolic process" EXACT []
synonym: "GABA metabolism" EXACT []
synonym: "gamma-aminobutyric acid metabolism" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0009308 ! amine metabolic process

[Term]
id: GO:0009449
name: gamma-aminobutyric acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai]
comment: See also the biological process term 'neurotransmitter biosynthetic process ; GO:0042136'.
synonym: "4-aminobutanoate biosynthesis" EXACT []
synonym: "4-aminobutanoate biosynthetic process" EXACT []
synonym: "4-aminobutyrate biosynthesis" EXACT []
synonym: "4-aminobutyrate biosynthetic process" EXACT []
synonym: "GABA biosynthesis" EXACT []
synonym: "GABA biosynthetic process" EXACT []
synonym: "gamma-aminobutyric acid anabolism" EXACT []
synonym: "gamma-aminobutyric acid biosynthesis" EXACT []
synonym: "gamma-aminobutyric acid formation" EXACT []
synonym: "gamma-aminobutyric acid synthesis" EXACT []
is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process

[Term]
id: GO:0009450
name: gamma-aminobutyric acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai]
comment: See also the biological process term 'neurotransmitter catabolic process ; GO:0042135'.
subset: gosubset_prok
synonym: "4-aminobutanoate catabolic process" EXACT []
synonym: "4-aminobutanoate catabolism" EXACT []
synonym: "4-aminobutyrate catabolic process" EXACT []
synonym: "4-aminobutyrate catabolism" EXACT []
synonym: "GABA catabolic process" EXACT []
synonym: "GABA catabolism" EXACT []
synonym: "gamma-aminobutyric acid breakdown" EXACT []
synonym: "gamma-aminobutyric acid catabolism" EXACT []
synonym: "gamma-aminobutyric acid degradation" EXACT []
xref: MetaCyc:4AMINOBUTMETAB-PWY
is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process
is_a: GO:0042219 ! cellular amino acid derivative catabolic process

[Term]
id: GO:0009451
name: RNA modification
namespace: biological_process
alt_id: GO:0016547
def: "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337 "Modification and Editing of RNA"]
comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing.
subset: gosubset_prok
synonym: "RNA editing" EXACT []
xref: Wikipedia:RNA_editing
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0043412 ! macromolecule modification

[Term]
id: GO:0009452
name: RNA capping
namespace: biological_process
def: "The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent RNA polymerase II transcript." [PMID:9266685]
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0009453
name: energy taxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:jl, PMID:11029423]
subset: gosubset_prok
synonym: "energytaxis" EXACT []
synonym: "taxis in response to energy source" EXACT []
is_a: GO:0042330 ! taxis

[Term]
id: GO:0009454
name: aerotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to environmental oxygen." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "taxis in response to atmospheric oxygen" EXACT []
is_a: GO:0006935 ! chemotaxis
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0009455
name: redox taxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to redox potential." [GOC:jl, PMID:11029423]
synonym: "redoxtaxis" EXACT []
synonym: "taxis in response to redox potential" EXACT []
synonym: "taxis in response to redox stimulus" EXACT []
is_a: GO:0006935 ! chemotaxis
is_a: GO:0009453 ! energy taxis
is_a: GO:0051775 ! response to redox state

[Term]
id: GO:0009457
name: flavodoxin
namespace: molecular_function
def: "OBSOLETE. A group of small electron carriers, characteristic of anaerobic bacteria, photosynthetic bacteria, cyanobacteria and eukaryotic algae. Contain flavin mononucleotide." [GOC:kd]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009458
name: cytochrome
namespace: molecular_function
def: "OBSOLETE. A hemeprotein whose characteristic mode of action involves transfer of reducing equivalents associated with a reversible change in oxidation state of the prosthetic group. This redox change involves a single electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom." [PMID:1655423]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0045153
consider: GO:0045154
consider: GO:0045155
consider: GO:0045156
consider: GO:0045157
consider: GO:0045158

[Term]
id: GO:0009459
name: cytochrome a
namespace: molecular_function
def: "OBSOLETE. A cytochrome containing heme a." [GOC:kd]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0045154

[Term]
id: GO:0009460
name: cytochrome b
namespace: molecular_function
def: "OBSOLETE. A cytochrome containing noncovalently bound protoheme (iron protoporphyrin IX; heme b)." [GOC:kd]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009461
name: cytochrome c
namespace: molecular_function
def: "OBSOLETE. A cytochrome containing heme bound to the protein by one or, more (commonly two) thioether bonds involving sulfhydryl groups of cysteine residues." [GOC:kd]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0045155

[Term]
id: GO:0009462
name: cytochrome d
namespace: molecular_function
def: "OBSOLETE. A cytochrome in which the prosthetic group is a tetrapyrrolic chelate of iron in which the degree of conjugation of double bonds is less than in porphyrin. This definition would appear to include siroheme proteins (e.g. nitrite and sulfite reductases), but these are not cytochromes." [GOC:kd, PMID:1655423]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009463
name: cytochrome b/b6
namespace: molecular_function
def: "OBSOLETE. Diheme cytochrome b; cytochrome b has the hemes b(562) and b(566) and is a component of the mitochondrial respiratory chain complex III. Cytochrome b6 is a component of bc complex acting between photosystems II and I of photosynthesis." [ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0045158

[Term]
id: GO:0009464
name: cytochrome b5
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009465
name: soluble cytochrome b562
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0045153

[Term]
id: GO:0009466
name: class I cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009467
name: monoheme class I cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009468
name: diheme class I cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009469
name: class II cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009470
name: class IIa cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009471
name: class III cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009472
name: cytochrome c3 (tetraheme)
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009473
name: cytochrome c7 (triheme)
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009474
name: nonaheme cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009475
name: high-molecular-weight cytochrome c (hexadecaheme)
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009476
name: class IV cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009477
name: cytochrome c1
namespace: molecular_function
def: "OBSOLETE. A cytochrome c that is an integral component of the mitochondrial respiratory complex III. Functions as an electron donor to cytochrome c." [PMID:1655423]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0045153

[Term]
id: GO:0009478
name: cytochrome c554
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009479
name: cytochrome f
namespace: molecular_function
def: "OBSOLETE. A cytochrome c that is characteristic of green plants and transfers electrons to plastocyanin." [PMID:1655423]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0045158

[Term]
id: GO:0009480
name: class IIb cytochrome c
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0009481
name: aa3-type cytochrome c oxidase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
comment: This term was made obsolete because it describes a class of gene products rather than a molecular function.
is_obsolete: true
replaced_by: GO:0004129

[Term]
id: GO:0009482
name: ba3-type cytochrome c oxidase
namespace: molecular_function
alt_id: GO:0009484
def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
comment: This term was made obsolete because it describes a class of gene products rather than a molecular function.
is_obsolete: true
replaced_by: GO:0004129

[Term]
id: GO:0009483
name: caa3-type cytochrome c oxidase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
comment: This term was made obsolete because it describes a class of gene products rather than a molecular function.
is_obsolete: true
replaced_by: GO:0004129

[Term]
id: GO:0009485
name: cbb3-type cytochrome c oxidase
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]
comment: This term was made obsolete because it describes a class of gene products rather than a molecular function.
is_obsolete: true
replaced_by: GO:0004129

[Term]
id: GO:0009486
name: cytochrome bo3 ubiquinol oxidase activity
namespace: molecular_function
xref: EC:1.10.3.-
is_a: GO:0008827 ! cytochrome o ubiquinol oxidase activity

[Term]
id: GO:0009487
name: glutaredoxin
namespace: molecular_function
def: "OBSOLETE. A small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:kd]
comment: This term was made obsolete because it represent a gene product.
is_obsolete: true
consider: GO:0006467
consider: GO:0015036
consider: GO:0015038

[Term]
id: GO:0009488
name: amicyanin
namespace: molecular_function
def: "OBSOLETE. A copper-containing protein that acts as an electron carrier between methylamine dehydrogenase and cytochrome c." [PMID:1655423]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009489
name: rubredoxin
namespace: molecular_function
def: "OBSOLETE. A low molecular weight mononuclear iron protein involved in electron transfer, with an iron tetrahedrally coordinated by the sulfurs of four conserved cysteine residues." [GOC:kd]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009490
name: mononuclear iron electron carrier
namespace: molecular_function
def: "OBSOLETE. A mononuclear iron entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009491
name: redox-active disulfide bond electron carrier
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "redox-active disulphide bond electron carrier" EXACT []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009492
name: 2Fe-2S electron transfer carrier
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009493
name: adrenodoxin-type ferredoxin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009494
name: chloroplast-type ferredoxin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009495
name: thioredoxin-like 2Fe-2S ferredoxin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009496
name: plastoquinol-plastocyanin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin." [EC:1.10.99.1]
subset: gosubset_prok
synonym: "cytochrome b6f" NARROW [EC:1.10.99.1]
synonym: "plastoquinol/plastocyanin oxidoreductase activity" EXACT [EC:1.10.99.1]
synonym: "plastoquinol:oxidized-plastocyanin oxidoreductase activity" EXACT [EC:1.10.99.1]
xref: EC:1.10.99.1
xref: MetaCyc:PLASTOQUINOL--PLASTOCYANIN-REDUCTASE-RXN
is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors

[Term]
id: GO:0009497
name: 3Fe-4S/4Fe-4S electron transfer carrier
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009498
name: bacterial-type ferredoxin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009499
name: monocluster bacterial-type ferredoxin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009500
name: dicluster bacterial-type ferredoxin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0009501
name: amyloplast
namespace: cellular_component
def: "A plastid whose main function is to synthesize and store starch." [ISBN:0140514031]
xref: Wikipedia:Amyloplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009502
name: photosynthetic electron transport chain
namespace: cellular_component
def: "OBSOLETE. A series of membrane-linked oxidation-reduction reactions in which electrons are transferred from an initial electron donor through a series of intermediates to a final electron acceptor (usually oxygen)." [GOC:mtg_electron_transport, ISBN:014051403]
comment: This term was made obsolete because it represents a process.
is_obsolete: true
consider: GO:0009767

[Term]
id: GO:0009503
name: thylakoid light-harvesting complex
namespace: cellular_component
def: "A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. An example of this is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198547684]
is_a: GO:0030076 ! light-harvesting complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009535 ! chloroplast thylakoid membrane

[Term]
id: GO:0009504
name: cell plate
namespace: cellular_component
def: "The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equitorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells." [ISBN:0198547684]
xref: Wikipedia:Cell_plate
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009505
name: plant-type cell wall
namespace: cellular_component
def: "A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances." [ISBN:0471245208]
synonym: "cellulose and pectin-containing cell wall" EXACT []
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0009506
name: plasmodesma
namespace: cellular_component
def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "plasmodesmata" EXACT []
xref: Wikipedia:Plasmodesma
is_a: GO:0005911 ! cell-cell junction
relationship: part_of GO:0055044 ! symplast

[Term]
id: GO:0009507
name: chloroplast
namespace: cellular_component
def: "A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [ISBN:0471245208]
xref: Wikipedia:Chloroplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009508
name: plastid chromosome
namespace: cellular_component
def: "A circular DNA molecule containing plastid encoded genes." [ISBN:0943883999]
is_a: GO:0000229 ! cytoplasmic chromosome
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0042646 ! plastid nucleoid

[Term]
id: GO:0009509
name: chromoplast
namespace: cellular_component
def: "A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [ISBN:0471245208]
xref: Wikipedia:Chromoplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009510
name: plasmodesmatal desmotubule
namespace: cellular_component
alt_id: GO:0009572
def: "A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell." [http://biology.kenyon.edu/edwards/project/greg/pd.htm]
synonym: "desmotubule central rod" RELATED []
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009506 ! plasmodesma

[Term]
id: GO:0009511
name: plasmodesmatal endoplasmic reticulum
namespace: cellular_component
def: "Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells." [GOC:ai]
synonym: "plasmodesmatal ER" EXACT []
is_a: GO:0005783 ! endoplasmic reticulum
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0071212 ! subsynaptic reticulum
relationship: part_of GO:0009510 ! plasmodesmatal desmotubule

[Term]
id: GO:0009512
name: cytochrome b6f complex
namespace: cellular_component
def: "Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [ISBN:0943883999, PMID:16228398, PMID:16352458]
subset: gosubset_prok
synonym: "cyt b(6)f complex" EXACT []
synonym: "cyt b6-f complex" EXACT []
synonym: "cyt b6/f complex" EXACT []
synonym: "cyt b6f complex" EXACT []
synonym: "cytochrome b(6)f complex" EXACT []
synonym: "cytochrome b6-f complex" EXACT []
synonym: "cytochrome b6/f complex" EXACT []
xref: Wikipedia:Cytochrome_b6f_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044436 ! thylakoid part

[Term]
id: GO:0009513
name: etioplast
namespace: cellular_component
def: "A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [ISBN:0943883999]
xref: Wikipedia:Etioplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009514
name: glyoxysome
namespace: cellular_component
def: "A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds." [GOC:dhl, ISBN:0140514031]
xref: Wikipedia:Glyoxysome
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0009515
name: granal stacked thylakoid
namespace: cellular_component
def: "Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II." [GOC:lr]
synonym: "chloroplast stacked thylakoid" EXACT []
is_a: GO:0009534 ! chloroplast thylakoid
relationship: part_of GO:0009542 ! granum

[Term]
id: GO:0009516
name: leucoplast
namespace: cellular_component
def: "A colorless plastid involved in the synthesis of monoterpenes." [ISBN:0943883999]
xref: Wikipedia:Leucoplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009517
name: PSII associated light-harvesting complex II
namespace: cellular_component
def: "Protein-pigment complex associated with photosystem II." [GOC:lr, ISBN:0582227089]
synonym: "LHCII" EXACT []
is_a: GO:0009503 ! thylakoid light-harvesting complex

[Term]
id: GO:0009518
name: PSI associated light-harvesting complex I
namespace: cellular_component
def: "Protein-pigment complex associated with photosystem I." [GOC:lr]
synonym: "LHCI" EXACT []
is_a: GO:0009503 ! thylakoid light-harvesting complex

[Term]
id: GO:0009519
name: middle lamella
namespace: cellular_component
def: "Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells." [ISBN:0471245208]
xref: Wikipedia:Middle_lamella
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0009521
name: photosystem
namespace: cellular_component
alt_id: GO:0030090
def: "A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949]
subset: goslim_pir
subset: gosubset_prok
synonym: "reaction center" NARROW []
synonym: "reaction centre" NARROW []
xref: Wikipedia:Photosystem
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0034357 ! photosynthetic membrane

[Term]
id: GO:0009522
name: photosystem I
namespace: cellular_component
def: "A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation)." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949]
subset: gosubset_prok
is_a: GO:0009521 ! photosystem

[Term]
id: GO:0009523
name: photosystem II
namespace: cellular_component
def: "A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center." [GOC:ds, GOC:mah, ISBN:0943088399, PMID:9821949]
subset: gosubset_prok
xref: Wikipedia:Photosystem_II
is_a: GO:0009521 ! photosystem

[Term]
id: GO:0009524
name: phragmoplast
namespace: cellular_component
def: "Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules." [ISBN:0471245208]
xref: Wikipedia:Phragmoplast
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009525
name: phragmosome
namespace: cellular_component
def: "A flattened membranous vesicle containing cell wall components." [ISBN:0943883999]
xref: Wikipedia:Phragmosome
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009526
name: plastid envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:jy]
is_a: GO:0031967 ! organelle envelope
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0009527
name: plastid outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope." [GOC:lr]
is_a: GO:0031968 ! organelle outer membrane
is_a: GO:0042170 ! plastid membrane

[Term]
id: GO:0009528
name: plastid inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma." [GOC:lr]
is_a: GO:0019866 ! organelle inner membrane
is_a: GO:0042170 ! plastid membrane

[Term]
id: GO:0009529
name: plastid intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of the plastid envelope." [GOC:lr]
synonym: "plastid envelope lumen" EXACT []
is_a: GO:0031970 ! organelle envelope lumen
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009526 ! plastid envelope

[Term]
id: GO:0009530
name: primary cell wall
namespace: cellular_component
def: "A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0009505 ! plant-type cell wall
is_a: GO:0048196 ! middle lamella-containing extracellular matrix

[Term]
id: GO:0009531
name: secondary cell wall
namespace: cellular_component
def: "A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin." [GOC:jic, http://cancerweb.ncl.ac.uk]
xref: Wikipedia:Secondary_cell_wall
is_a: GO:0009505 ! plant-type cell wall
is_a: GO:0048196 ! middle lamella-containing extracellular matrix

[Term]
id: GO:0009532
name: plastid stroma
namespace: cellular_component
def: "The proteinaceous ground substance of plastids." [ISBN:047142520]
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0009533
name: chloroplast stromal thylakoid
namespace: cellular_component
def: "Unstacked thylakoids that connect the grana stacks through the stroma." [ISBN:0943883999]
is_a: GO:0009534 ! chloroplast thylakoid
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0009534
name: chloroplast thylakoid
namespace: cellular_component
def: "Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0943883999]
is_a: GO:0031976 ! plastid thylakoid
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0009535
name: chloroplast thylakoid membrane
namespace: cellular_component
def: "The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
is_a: GO:0044434 ! chloroplast part
is_a: GO:0055035 ! plastid thylakoid membrane
relationship: part_of GO:0009534 ! chloroplast thylakoid

[Term]
id: GO:0009536
name: plastid
namespace: cellular_component
def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
xref: Wikipedia:Plastid
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0009537
name: proplastid
namespace: cellular_component
def: "The precursor of other plastids." [ISBN:0943883999]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009538
name: photosystem I reaction center
namespace: cellular_component
def: "A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin." [GOC:kd, ISBN:0943088399]
subset: gosubset_prok
synonym: "photosystem I reaction centre" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0009522 ! photosystem I

[Term]
id: GO:0009539
name: photosystem II reaction center
namespace: cellular_component
def: "An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone." [GOC:kd, ISBN:0943088399]
subset: gosubset_prok
synonym: "photosystem II reaction centre" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0009523 ! photosystem II

[Term]
id: GO:0009540
name: zeaxanthin epoxidase activity
namespace: molecular_function
def: "Catalysis of the reactions: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O and antheraxanthin + NAD(P)H + H+ + O2 = violaxanthin + NAD(P)+ + H2O." [EC:1.14.13.90]
synonym: "zea-epoxidase activity" EXACT [EC:1.14.13.90]
synonym: "zeaxanthin,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.13.90]
xref: EC:1.14.13.90
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0009541
name: etioplast prolamellar body
namespace: cellular_component
def: "A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast." [ISBN:0140514031]
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009513 ! etioplast

[Term]
id: GO:0009542
name: granum
namespace: cellular_component
def: "Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis." [ISBN:014051403]
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0009543
name: chloroplast thylakoid lumen
namespace: cellular_component
def: "The cavity enclosed within the chloroplast thylakoid membrane. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:006501037]
is_a: GO:0031978 ! plastid thylakoid lumen
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009534 ! chloroplast thylakoid

[Term]
id: GO:0009544
name: chloroplast ATP synthase complex
namespace: cellular_component
def: "The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts." [ISBN:019854768]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009535 ! chloroplast thylakoid membrane

[Term]
id: GO:0009545
name: elaioplast
namespace: cellular_component
def: "A leucoplast in which oil is stored." [ISBN:0140514031]
xref: Wikipedia:Elaioplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009546
name: plasmodesmatal cytoplasmic sleeve
namespace: cellular_component
def: "The space between the plasma membrane and the desmotubule of a plasmodesma." [http://biology.kenyon.edu/edwards/project/greg/pd.htm]
synonym: "plasmodesmatal cytoplasmic annulus" EXACT []
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009506 ! plasmodesma

[Term]
id: GO:0009547
name: plastid ribosome
namespace: cellular_component
def: "A ribosome contained within a plastid." [GOC:tair_curators]
is_a: GO:0000313 ! organellar ribosome
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009532 ! plastid stroma

[Term]
id: GO:0009548
name: plasmodesmatal plasma membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a plasmodesma." [GOC:mah]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009506 ! plasmodesma

[Term]
id: GO:0009549
name: cellulose microfibril
namespace: cellular_component
def: "Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls where it is found as microfibrils laid down in orthogonal layers. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the cell." [GOC:jic, http://cancerweb.ncl.ac.uk, ISBN:0943088399]
is_a: GO:0001527 ! microfibril
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009530 ! primary cell wall
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0009550
name: primary plasmodesma
namespace: cellular_component
def: "A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis." [PMID:15012255]
synonym: "simple plasmodesma" EXACT []
is_a: GO:0009506 ! plasmodesma

[Term]
id: GO:0009551
name: secondary plasmodesma
namespace: cellular_component
def: "A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata." [PMID:15012255]
is_a: GO:0009506 ! plasmodesma

[Term]
id: GO:0009553
name: embryo sac development
namespace: biological_process
alt_id: GO:0048230
def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate." [GOC:mtg_plant, GOC:tb]
synonym: "female gametophyte development" EXACT []
is_a: GO:0048229 ! gametophyte development

[Term]
id: GO:0009554
name: megasporogenesis
namespace: biological_process
def: "The process by which the megasporocyte undergoes meiosis, giving rise to four haploid megaspores in the nucellus." [GOC:mtg_plant, GOC:tb]
synonym: "megaspore development" EXACT []
synonym: "megaspore mother cell meiosis" EXACT []
synonym: "meiosis of the megasporocyte" EXACT []
synonym: "meiotic division of the megasporocyte" EXACT []
is_a: GO:0048236 ! plant-type spore development
relationship: part_of GO:0009553 ! embryo sac development

[Term]
id: GO:0009555
name: pollen development
namespace: biological_process
alt_id: GO:0009564
alt_id: GO:0048231
def: "The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates." [GOC:mtg_plant, GOC:mtg_sensu, GOC:tb]
synonym: "formation of generative and vegetative cells" EXACT []
synonym: "male gametophyte development" EXACT []
synonym: "male gametophyte formation" EXACT []
synonym: "microgametophyte development" EXACT []
synonym: "pollen grain formation" EXACT []
is_a: GO:0048229 ! gametophyte development

[Term]
id: GO:0009556
name: microsporogenesis
namespace: biological_process
def: "The process by which the microsporocyte undergoes meiosis, giving rise to four haploid microspores." [GOC:mtg_plant, GOC:tb]
synonym: "microspore development" EXACT systematic_synonym []
is_a: GO:0048236 ! plant-type spore development
relationship: part_of GO:0009555 ! pollen development

[Term]
id: GO:0009557
name: antipodal cell differentiation
namespace: biological_process
def: "The process whereby an uncellularized nucleus cellularizes and acquires the specialized features of an antipodal cell." [GOC:jic, GOC:mtg_plant]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009558
name: cellularization of the embryo sac
namespace: biological_process
alt_id: GO:0009797
def: "The process by which the eight-nucleate single celled female gametophyte develops into the seven-celled female gametophyte. This mature structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. An example of this process is found in Arabidopsis thaliana." [GOC:jic, GOC:mtg_plant, GOC:mtg_sensu, ISBN:047186840X]
synonym: "cellularization" BROAD []
synonym: "cellularization of megagametophyte" EXACT []
synonym: "cellularization of the female gametophyte" EXACT []
is_a: GO:0007349 ! cellularization
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009559
name: embryo sac central cell differentiation
namespace: biological_process
def: "The process whereby the two uncellularized polar nuclei cellularize, fuse and acquire the specialized features of a mononucleate diploid central cell." [GOC:jic, GOC:mtg_plant]
synonym: "embryo sac endosperm mother cell differentiation" EXACT []
synonym: "female gametophyte central cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009560
name: embryo sac egg cell differentiation
namespace: biological_process
alt_id: GO:0048233
def: "The process whereby an uncellularized embryo sac nucleus cellularizes and acquires the specialized features of an egg cell. An example of this process is found in Arabidopsis thaliana." [GOC:jic, GOC:mtg_plant, GOC:mtg_sensu]
synonym: "female gamete generation" BROAD []
synonym: "female gametophyte egg cell differentiation" EXACT []
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0030154 ! cell differentiation
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007292 ! female gamete generation
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009561
name: megagametogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center." [GOC:jl, GOC:mtg_plant]
synonym: "embryo sac development from the megaspore" EXACT systematic_synonym []
synonym: "megagametophyte nucleus division" EXACT []
xref: Wikipedia:Megagametogenesis
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0009553 ! embryo sac development

[Term]
id: GO:0009562
name: embryo sac nuclear migration
namespace: biological_process
def: "The directed movement of an embryo sac nucleus to the pole or center of the cell." [GOC:jl, GOC:mtg_plant]
synonym: "embryo sac nucleus migration" EXACT []
synonym: "female gametophyte nuclear migration" EXACT []
synonym: "female gametophyte nucleus migration" EXACT []
synonym: "megagametophyte nuclear migration" EXACT []
synonym: "megagametophyte nucleus migration" EXACT []
is_a: GO:0007097 ! nuclear migration
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009563
name: synergid differentiation
namespace: biological_process
def: "The process whereby an uncellularized nucleus cellularizes and acquires the specialized features of a synergid cell." [GOC:jic]
synonym: "synergid cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0009566
name: fertilization
namespace: biological_process
def: "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: Wikipedia:Fertilisation
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0019953 ! sexual reproduction

[Term]
id: GO:0009567
name: double fertilization forming a zygote and endosperm
namespace: biological_process
def: "Fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb]
synonym: "double fertilization" EXACT []
is_a: GO:0009566 ! fertilization

[Term]
id: GO:0009568
name: amyloplast starch grain
namespace: cellular_component
def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978]
synonym: "amyloplast starch granule" EXACT []
is_a: GO:0043036 ! starch grain
relationship: part_of GO:0009501 ! amyloplast

[Term]
id: GO:0009569
name: chloroplast starch grain
namespace: cellular_component
def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in chloroplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "chloroplast starch granule" EXACT []
is_a: GO:0043036 ! starch grain
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0009570
name: chloroplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis." [ISBN:0198547684]
is_a: GO:0009532 ! plastid stroma
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0009571
name: proplastid stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a proplastid." [GOC:jl]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009537 ! proplastid

[Term]
id: GO:0009573
name: chloroplast ribulose bisphosphate carboxylase complex
namespace: cellular_component
def: "A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. An example of this component is found in Arabidopsis thaliana." [GOC:mlg, GOC:mtg_sensu]
synonym: "chloroplast RubisCO complex" EXACT []
is_a: GO:0044434 ! chloroplast part
is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0009574
name: preprophase band
namespace: cellular_component
def: "A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: Wikipedia:Preprophase_band
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0009575
name: chromoplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material." [GOC:jl]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009509 ! chromoplast

[Term]
id: GO:0009576
name: leucoplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a leucoplast." [GOC:mah]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009516 ! leucoplast

[Term]
id: GO:0009577
name: elaioplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of an elaioplast." [GOC:mah]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009545 ! elaioplast

[Term]
id: GO:0009578
name: etioplast stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA." [GOC:jl]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009513 ! etioplast

[Term]
id: GO:0009579
name: thylakoid
namespace: cellular_component
def: "A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:ds, GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "photosynthetic membrane" RELATED []
xref: Wikipedia:Thylakoid
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0009580
name: thylakoid (sensu Bacteria)
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific children exist.
is_obsolete: true
consider: GO:0030075
consider: GO:0042716

[Term]
id: GO:0009581
name: detection of external stimulus
namespace: biological_process
def: "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." [GOC:hb]
subset: gosubset_prok
synonym: "perception of external stimulus" RELATED []
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009582
name: detection of abiotic stimulus
namespace: biological_process
def: "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." [GOC:hb]
subset: gosubset_prok
synonym: "perception of abiotic stimulus" RELATED []
is_a: GO:0009628 ! response to abiotic stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009583
name: detection of light stimulus
namespace: biological_process
def: "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." [GOC:go_curators]
subset: gosubset_prok
synonym: "detection of light" EXACT []
synonym: "perception of light" RELATED []
is_a: GO:0009416 ! response to light stimulus
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus

[Term]
id: GO:0009584
name: detection of visible light
namespace: biological_process
def: "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "perception of visible light" RELATED []
is_a: GO:0009583 ! detection of light stimulus

[Term]
id: GO:0009585
name: red, far-red light phototransduction
namespace: biological_process
def: "The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm." [GOC:mah]
subset: gosubset_prok
synonym: "phytochrome signaling pathway" BROAD []
synonym: "red-sensitive opsin" RELATED []
is_a: GO:0007602 ! phototransduction
relationship: part_of GO:0010017 ! red or far-red light signaling pathway

[Term]
id: GO:0009586
name: rhodopsin mediated phototransduction
namespace: biological_process
def: "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events then required to return the rhodopsin containing cell to the unexcited state." [GOC:hb]
is_a: GO:0007603 ! phototransduction, visible light
is_a: GO:0050908 ! detection of light stimulus involved in visual perception

[Term]
id: GO:0009587
name: phototrophin mediated phototransduction
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
is_obsolete: true
replaced_by: GO:0007602

[Term]
id: GO:0009588
name: UV-A, blue light phototransduction
namespace: biological_process
def: "The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of approximately 400-500 nm." [GOC:mah]
synonym: "blue-sensitive opsin" RELATED []
synonym: "short-wave-sensitive opsin" RELATED []
synonym: "violet-sensitive opsin" RELATED []
is_a: GO:0007602 ! phototransduction

[Term]
id: GO:0009589
name: detection of UV
namespace: biological_process
def: "The series of events in which an ultraviolet radiation (UV light) stimulus is received by a cell and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:go_curators, GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "detection of ultraviolet light stimulus" EXACT []
synonym: "detection of ultraviolet radiation stimulus" EXACT []
synonym: "detection of UV light stimulus" EXACT []
synonym: "detection of UV radiation stimulus" EXACT []
synonym: "perception of UV" RELATED []
is_a: GO:0009411 ! response to UV
is_a: GO:0009583 ! detection of light stimulus

[Term]
id: GO:0009590
name: detection of gravity
namespace: biological_process
def: "The series of events in which a gravitational stimulus is received by a cell and converted into a molecular signal." [GOC:hb]
synonym: "perception of gravity" RELATED []
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus
is_a: GO:0009629 ! response to gravity

[Term]
id: GO:0009591
name: perception of mechanical stimulus
namespace: biological_process
alt_id: GO:0007609
def: "OBSOLETE. The series of events by which a mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:hb]
comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage.
is_obsolete: true
consider: GO:0050954

[Term]
id: GO:0009593
name: detection of chemical stimulus
namespace: biological_process
def: "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl]
synonym: "chemoperception" EXACT []
synonym: "detection of chemical substance" EXACT []
synonym: "perception of chemical stimulus" RELATED []
synonym: "perception of chemical substance" RELATED []
is_a: GO:0042221 ! response to chemical stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009594
name: detection of nutrient
namespace: biological_process
def: "The series of events in which a nutrient stimulus is received by a cell and converted into a molecular signal." [GOC:jl]
synonym: "detection of nutrients" EXACT []
synonym: "nutrient sensing" RELATED []
synonym: "perception of nutrients" RELATED []
is_a: GO:0007584 ! response to nutrient
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0009595
name: detection of biotic stimulus
namespace: biological_process
alt_id: GO:0009596
def: "The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal." [GOC:hb]
subset: gosubset_prok
synonym: "perception of biotic stimulus" RELATED []
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009597
name: detection of virus
namespace: biological_process
def: "The series of events in which a stimulus from a virus is received and converted into a molecular signal." [GOC:hb]
subset: gosubset_prok
synonym: "perception of virus" RELATED []
is_a: GO:0009602 ! detection of symbiont
is_a: GO:0009615 ! response to virus

[Term]
id: GO:0009600
name: detection of nematode
namespace: biological_process
def: "The series of events in which a stimulus from a nematode is received and converted into a molecular signal." [GOC:hb]
synonym: "perception of nematode" RELATED []
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009595 ! detection of biotic stimulus
is_a: GO:0009624 ! response to nematode

[Term]
id: GO:0009601
name: detection of insect
namespace: biological_process
def: "The series of events in which a stimulus from an insect is received and converted into a molecular signal." [GOC:hb]
synonym: "perception of insect" RELATED []
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009595 ! detection of biotic stimulus
is_a: GO:0009625 ! response to insect

[Term]
id: GO:0009602
name: detection of symbiont
namespace: biological_process
def: "The series of events in which a stimulus from a symbiont (an organism living in close physical association with an organism of a different species) is received and converted into a molecular signal. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "perception of symbiont" RELATED []
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009595 ! detection of biotic stimulus
is_a: GO:0009608 ! response to symbiont

[Term]
id: GO:0009603
name: detection of symbiotic fungus
namespace: biological_process
def: "The series of events in which a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "detection of symbiotic fungi" EXACT []
synonym: "perception of symbiotic fungi" RELATED []
synonym: "perception of symbiotic fungus" RELATED []
is_a: GO:0009602 ! detection of symbiont
is_a: GO:0009610 ! response to symbiotic fungus
is_a: GO:0016046 ! detection of fungus

[Term]
id: GO:0009604
name: detection of symbiotic bacterium
namespace: biological_process
def: "The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "detection of symbiotic bacteria" EXACT []
synonym: "perception of symbiotic bacteria" RELATED []
synonym: "perception of symbiotic bacterium" RELATED []
is_a: GO:0009602 ! detection of symbiont
is_a: GO:0009609 ! response to symbiotic bacterium
is_a: GO:0016045 ! detection of bacterium

[Term]
id: GO:0009605
name: response to external stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb]
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
synonym: "response to environmental stimulus" EXACT []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009606
name: tropism
namespace: biological_process
def: "The movement of an organism, or part of an organism, in response to an external source of stimulus, usually toward or away from it." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: goslim_plant
xref: Wikipedia:Tropism
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0009607
name: response to biotic stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb]
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
synonym: "response to biotic stress" NARROW []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009608
name: response to symbiont
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "response of host to symbiont" RELATED []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009609
name: response to symbiotic bacterium
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "response to symbiotic bacteria" EXACT []
is_a: GO:0009608 ! response to symbiont
is_a: GO:0009617 ! response to bacterium

[Term]
id: GO:0009610
name: response to symbiotic fungus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "response to symbiotic fungi" EXACT []
is_a: GO:0009608 ! response to symbiont
is_a: GO:0009620 ! response to fungus

[Term]
id: GO:0009611
name: response to wounding
namespace: biological_process
alt_id: GO:0002245
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators]
synonym: "physiological response to wounding" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0009605 ! response to external stimulus

[Term]
id: GO:0009612
name: response to mechanical stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb]
subset: gosubset_prok
synonym: "chemi-mechanical coupling" RELATED []
synonym: "mechanical stimulus response" EXACT []
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009614
name: disease resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0051707

[Term]
id: GO:0009615
name: response to virus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:hb]
subset: gosubset_prok
synonym: "response to viruses" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009616
name: virus induced gene silencing
namespace: biological_process
def: "Specific posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes. This silencing is triggered by viral infection, and occurs through a specific decrease in the level of mRNA of both host and viral genes." [GOC:jl]
synonym: "VIGS" EXACT []
synonym: "virus-induced gene silencing" EXACT []
is_a: GO:0045087 ! innate immune response
is_a: GO:0051607 ! defense response to virus
is_a: GO:0052018 ! modulation by symbiont of RNA levels in host

[Term]
id: GO:0009617
name: response to bacterium
namespace: biological_process
alt_id: GO:0009618
alt_id: GO:0009680
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb]
subset: gosubset_prok
synonym: "response to bacteria" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009619
name: resistance to pathogenic bacteria
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0009617

[Term]
id: GO:0009620
name: response to fungus
namespace: biological_process
alt_id: GO:0009621
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb]
synonym: "response to fungi" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009622
name: resistance to pathogenic fungi
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0009620

[Term]
id: GO:0009623
name: response to parasitic fungus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic fungus, a fungus which spends all or part of its life in or on another organism from which it obtains nourishment and/or protection." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "response to parasitic fungi" EXACT []
is_a: GO:0009610 ! response to symbiotic fungus

[Term]
id: GO:0009624
name: response to nematode
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode." [GOC:hb]
synonym: "response to nematodes" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009625
name: response to insect
namespace: biological_process
alt_id: GO:0043019
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect." [GOC:hb]
synonym: "response to insects" EXACT []
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009626
name: plant-type hypersensitive response
namespace: biological_process
def: "The rapid, localized death of plant cells in response to invasion by a pathogen." [ISBN:0582227089]
comment: Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider the biological process term 'modulation by symbiont of host defense-related programmed cell death ; GO:0034053'.
synonym: "HR" EXACT []
synonym: "HR-PCD" EXACT []
synonym: "plant hypersensitive response" EXACT []
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0034050 ! host programmed cell death induced by symbiont
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0009627
name: systemic acquired resistance
namespace: biological_process
def: "The salicylic acid mediated response to a pathogen which confers broad spectrum resistance." [GOC:lr, ISBN:052143641]
synonym: "salicylic acid-dependent systemic resistance" EXACT []
xref: Wikipedia:Systemic_acquired_resistance
is_a: GO:0009814 ! defense response, incompatible interaction

[Term]
id: GO:0009628
name: response to abiotic stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:hb]
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
synonym: "response to abiotic stress" NARROW []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009629
name: response to gravity
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." [GOC:hb]
synonym: "response to gravitational stimulus" EXACT []
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0009630
name: gravitropism
namespace: biological_process
def: "The orientation of plant parts under the stimulation of gravity." [ISBN:0198547684]
synonym: "geotropism" EXACT []
xref: Wikipedia:Gravitropism
is_a: GO:0009606 ! tropism
is_a: GO:0009629 ! response to gravity

[Term]
id: GO:0009631
name: cold acclimation
namespace: biological_process
def: "Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr]
subset: gosubset_prok
is_a: GO:0009409 ! response to cold

[Term]
id: GO:0009632
name: freezing tolerance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process.
is_obsolete: true
consider: GO:0009409

[Term]
id: GO:0009633
name: drought tolerance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process.
is_obsolete: true
consider: GO:0009414
consider: GO:0009819

[Term]
id: GO:0009634
name: heavy metal sensitivity/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
consider: GO:0010038

[Term]
id: GO:0009635
name: response to herbicide
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "herbicide susceptibility/resistance" RELATED []
is_a: GO:0006950 ! response to stress
is_a: GO:0009636 ! response to toxin

[Term]
id: GO:0009636
name: response to toxin
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxin stimulus." [GOC:lr]
subset: gosubset_prok
synonym: "detoxification response" NARROW []
synonym: "toxin resistance" RELATED []
synonym: "toxin susceptibility/resistance" RELATED []
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0009637
name: response to blue light
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:ai, GOC:mtg_far_red]
synonym: "response to blue light stimulus" EXACT []
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0009638
name: phototropism
namespace: biological_process
def: "The movement of an organism, or part of an organism, in response to a light stimulus, usually toward or away from it." [GOC:jl, GOC:mtg_far_red, http://cancerweb.ncl.ac.uk/]
xref: Wikipedia:Phototropism
is_a: GO:0009606 ! tropism
is_a: GO:0009637 ! response to blue light

[Term]
id: GO:0009639
name: response to red or far red light
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:ai, GOC:mtg_far_red]
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0009640
name: photomorphogenesis
namespace: biological_process
def: "The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis." [GOC:lr]
synonym: "plant development in response to light" EXACT systematic_synonym []
xref: Wikipedia:Photomorphogenesis
is_a: GO:0009639 ! response to red or far red light
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0009641
name: shade avoidance
namespace: biological_process
def: "Shade avoidance is a set of responses that plants display when they are subjected to the shade of another plant. It often includes elongation, altered flowering time, increased apical dominance and altered partitioning of resources. Plants are able to distinguish between the shade of an inanimate object (e.g. a rock) and the shade of another plant due to the altered balance between red and far-red light in the shade of a plant; this balance between red and far-red light is perceived by phytochrome." [Wikipedia:Shade_avoidance]
xref: Wikipedia:Shade_avoidance
is_a: GO:0009639 ! response to red or far red light

[Term]
id: GO:0009642
name: response to light intensity
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:go_curators]
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0009643
name: photosynthetic acclimation
namespace: biological_process
is_a: GO:0009642 ! response to light intensity

[Term]
id: GO:0009644
name: response to high light intensity
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:go_curators]
is_a: GO:0009642 ! response to light intensity

[Term]
id: GO:0009645
name: response to low light intensity stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:go_curators, GOC:mtg_far_red]
is_a: GO:0009642 ! response to light intensity

[Term]
id: GO:0009646
name: response to absence of light
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:go_curators]
is_a: GO:0009642 ! response to light intensity

[Term]
id: GO:0009647
name: skotomorphogenesis
namespace: biological_process
def: "The control of plant growth, development, and differentiation in response to growth in darkness." [http://www.plantphys.net/article.php?ch=t&id=63, PMID:15012288]
synonym: "etiolation" RELATED []
is_a: GO:0009646 ! response to absence of light
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0009648
name: photoperiodism
namespace: biological_process
def: "A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "response to day length" EXACT []
synonym: "response to night length" EXACT []
synonym: "response to photoperiod" EXACT []
xref: Wikipedia:Photoperiodism
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0009649
name: entrainment of circadian clock
namespace: biological_process
def: "The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jic]
synonym: "regulation of circadian rhythm phase" RELATED []
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0042752 ! regulation of circadian rhythm

[Term]
id: GO:0009650
name: UV protection
namespace: biological_process
def: "Any process by which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml]
subset: gosubset_prok
synonym: "ultraviolet protection" EXACT []
synonym: "ultraviolet resistance" RELATED []
synonym: "ultraviolet tolerance" RELATED []
synonym: "UV resistance" RELATED []
synonym: "UV tolerance" RELATED []
is_a: GO:0009411 ! response to UV

[Term]
id: GO:0009651
name: response to salt stress
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]
subset: gosubset_prok
synonym: "response to ionic osmotic stress" EXACT []
synonym: "salinity response" EXACT []
is_a: GO:0006970 ! response to osmotic stress

[Term]
id: GO:0009652
name: thigmotropism
namespace: biological_process
def: "The movement of an organism, or part of an organism, such as leaves or tendrils, in response to a touch stimulus, usually toward or away from it." [GOC:jl, http://cancerweb.ncl.ac.uk/]
xref: Wikipedia:Thigmotropism
is_a: GO:0009606 ! tropism
is_a: GO:0009612 ! response to mechanical stimulus

[Term]
id: GO:0009653
name: anatomical structure morphogenesis
namespace: biological_process
def: "The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125]
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
synonym: "anatomical structure organization" EXACT []
synonym: "embryogenesis and morphogenesis" BROAD []
synonym: "morphogenesis" EXACT []
xref: Wikipedia:Morphogenesis
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0048856 ! anatomical structure development

[Term]
id: GO:0009654
name: oxygen evolving complex
namespace: cellular_component
def: "A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ)." [InterPro:IPR002683]
subset: gosubset_prok
xref: Wikipedia:Oxygen_evolving_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009523 ! photosystem II

[Term]
id: GO:0009655
name: PSII associated light-harvesting complex II, core complex
namespace: cellular_component
def: "The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center." [GOC:lr]
subset: gosubset_prok
synonym: "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex" NARROW []
synonym: "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex" NARROW []
synonym: "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II

[Term]
id: GO:0009656
name: PSII associated light-harvesting complex II, peripheral complex
namespace: cellular_component
def: "Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light." [GOC:lr]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II

[Term]
id: GO:0009657
name: plastid organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plastid." [GOC:mah]
subset: goslim_pir
synonym: "plastid organisation" EXACT [GOC:curators]
synonym: "plastid organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0009658
name: chloroplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast." [GOC:jic]
synonym: "chloroplast organisation" EXACT [GOC:curators]
synonym: "chloroplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0009659
name: leucoplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jic]
synonym: "leucoplast organisation" EXACT [GOC:curators]
synonym: "leucoplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0009660
name: amyloplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an amyloplast. An amyloplast is a plastid whose main function is to synthesize and store starch." [GOC:jic]
synonym: "amyloplast organisation" EXACT [GOC:curators]
synonym: "amyloplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0009661
name: chromoplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chromoplast. A chromoplast is a plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [GOC:jic]
synonym: "chromoplast organisation" EXACT [GOC:curators]
synonym: "chromoplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0009662
name: etioplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an etioplast. An etioplast is a plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [GOC:jic]
synonym: "etioplast organisation" EXACT [GOC:curators]
synonym: "etioplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0009663
name: plasmodesma organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasmodesma, a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [GOC:mah]
synonym: "plasmodesma organisation" EXACT [GOC:curators]
synonym: "plasmodesma organization and biogenesis" RELATED [GOC:curators]
synonym: "plasmodesmata organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045216 ! cell-cell junction organization

[Term]
id: GO:0009664
name: plant-type cell wall organization
namespace: biological_process
def: "A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana." [GOC:jic, GOC:mtg_sensu]
synonym: "cell wall organization and biogenesis" NARROW []
synonym: "cellulose and pectin-containing cell wall organization and biogenesis" RELATED [GOC:mah]
synonym: "plant-type cell wall organisation" EXACT [GOC:curators]
synonym: "plant-type cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071555 ! cell wall organization
is_a: GO:0071669 ! plant-type cell wall organization or biogenesis

[Term]
id: GO:0009665
name: plastid inheritance
namespace: biological_process
def: "The partitioning of plastids between daughter cells at cell division." [GOC:mah]
is_a: GO:0009657 ! plastid organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0009666
name: plastid outer membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the outer membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "plastid outer membrane organisation" EXACT [GOC:curators]
synonym: "plastid outer membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009668 ! plastid membrane organization

[Term]
id: GO:0009667
name: plastid inner membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the inner membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "plastid inner membrane organisation" EXACT [GOC:curators]
synonym: "plastid inner membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009668 ! plastid membrane organization

[Term]
id: GO:0009668
name: plastid membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "plastid membrane organisation" EXACT [GOC:curators]
synonym: "plastid membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016044 ! cellular membrane organization
relationship: part_of GO:0009657 ! plastid organization

[Term]
id: GO:0009669
name: sucrose:monovalent cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in)." [GOC:jy, TC:2.A.2.-.-, TC:2.A.2.4.1]
synonym: "sucrose permease activity" RELATED []
is_a: GO:0008515 ! sucrose transmembrane transporter activity
is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity

[Term]
id: GO:0009670
name: triose-phosphate transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015122
def: "Enables the exchange of an organic three carbon compound phosphate ester for inorganic phosphate." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.7.-.-]
synonym: "triose phosphate transporter activity" EXACT []
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity

[Term]
id: GO:0009671
name: nitrate:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in)." [GOC:mah, PMID:10066586, PMID:1990981]
synonym: "nitrate(chlorate):hydrogen symporter activity" EXACT []
synonym: "nitrate(chlorate):proton symporter activity" EXACT []
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0009672
name: auxin:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in)." [PMID:8688077]
synonym: "auxin:proton symporter activity" EXACT []
is_a: GO:0015294 ! solute:cation symporter activity

[Term]
id: GO:0009673
name: low affinity phosphate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of phosphate from one side of the membrane to the other. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.20.-.-]
is_a: GO:0015114 ! phosphate transmembrane transporter activity

[Term]
id: GO:0009674
name: potassium:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in)." [TC:2.A.38.3.1]
synonym: "high affinity potassium transporter" RELATED []
is_a: GO:0022820 ! potassium ion symporter activity

[Term]
id: GO:0009675
name: high affinity sulfate:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah]
synonym: "high affinity sulfate:proton symporter activity" EXACT []
synonym: "high affinity sulphate:hydrogen symporter activity" EXACT []
is_a: GO:0008512 ! sulfate:hydrogen symporter activity

[Term]
id: GO:0009676
name: low affinity sulfate:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mah, PMID:7568135]
synonym: "low affinity sulfate:proton symporter activity" EXACT []
synonym: "low affinity sulphate:hydrogen symporter activity" EXACT []
is_a: GO:0008512 ! sulfate:hydrogen symporter activity

[Term]
id: GO:0009677
name: double fertilization forming two zygotes
namespace: biological_process
def: "Rudimentary double fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the ventral canal cell nucleus to form a second zygote, which soon degenerates. An example of this process is found in the Gnetophytes, such as Welwitschia mirabilis." [GOC:mtg_sensu, GOC:tb]
is_a: GO:0009566 ! fertilization

[Term]
id: GO:0009678
name: hydrogen-translocating pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:3.A.10.-.-]
subset: gosubset_prok
synonym: "proton-translocating pyrophosphatase activity" EXACT []
is_a: GO:0015405 ! P-P-bond-hydrolysis-driven transmembrane transporter activity
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0009679
name: hexose:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in)." [TC:2.A.1.-.-]
subset: gosubset_prok
synonym: "hexose:proton symporter activity" EXACT []
is_a: GO:0005351 ! sugar:hydrogen symporter activity
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0009682
name: induced systemic resistance
namespace: biological_process
def: "A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling." [PMID:10234273]
is_a: GO:0042742 ! defense response to bacterium
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0009683
name: indoleacetic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:mah]
subset: gosubset_prok
synonym: "IAA metabolic process" EXACT []
synonym: "indole acetic acid metabolic process" EXACT []
synonym: "indole acetic acid metabolism" EXACT []
synonym: "indoleacetic acid metabolism" EXACT []
is_a: GO:0009850 ! auxin metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process
is_a: GO:0042434 ! indole derivative metabolic process

[Term]
id: GO:0009684
name: indoleacetic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [ISBN:0387969845]
subset: gosubset_prok
synonym: "IAA biosynthetic process" EXACT []
synonym: "indole acetic acid biosynthesis" EXACT []
synonym: "indole acetic acid biosynthetic process" EXACT []
synonym: "indole-3-acetate biosynthesis" EXACT []
synonym: "indole-3-acetate biosynthetic process" EXACT []
synonym: "indole-acetic acid biosynthesis" EXACT []
synonym: "indole-acetic acid biosynthetic process" RELATED []
synonym: "indoleacetic acid anabolism" EXACT []
synonym: "indoleacetic acid biosynthesis" EXACT []
synonym: "indoleacetic acid formation" EXACT []
synonym: "indoleacetic acid synthesis" EXACT []
is_a: GO:0009683 ! indoleacetic acid metabolic process
is_a: GO:0009851 ! auxin biosynthetic process
is_a: GO:0042435 ! indole derivative biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0009685
name: gibberellin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845]
subset: gosubset_prok
synonym: "gibberellic acid metabolic process" NARROW []
synonym: "gibberellic acid metabolism" NARROW []
synonym: "gibberellin metabolism" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0009686
name: gibberellin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845]
subset: gosubset_prok
synonym: "gibberellic acid anabolism" NARROW []
synonym: "gibberellic acid biosynthesis" NARROW []
synonym: "gibberellic acid biosynthetic process" NARROW []
synonym: "gibberellic acid formation" NARROW []
synonym: "gibberellic acid synthesis" NARROW []
synonym: "gibberellin biosynthesis" EXACT []
xref: MetaCyc:PWY-5035
xref: MetaCyc:PWY-5036
xref: MetaCyc:PWY-5052
xref: MetaCyc:PWY-5070
is_a: GO:0009685 ! gibberellin metabolic process
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0009687
name: abscisic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845]
subset: gosubset_prok
synonym: "abscisic acid metabolism" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043288 ! apocarotenoid metabolic process

[Term]
id: GO:0009688
name: abscisic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845]
subset: gosubset_prok
synonym: "abscisic acid anabolism" EXACT []
synonym: "abscisic acid biosynthesis" EXACT []
synonym: "abscisic acid formation" EXACT []
synonym: "abscisic acid synthesis" EXACT []
xref: MetaCyc:PWY-695
is_a: GO:0009687 ! abscisic acid metabolic process
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0043289 ! apocarotenoid biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0009689
name: induction of phytoalexin biosynthetic process
namespace: biological_process
def: "The activation of the chemical reactions and pathways resulting in the formation of phytoalexins, low-molecular mass, lipophilic antimicrobial compounds that accumulate rapidly at sites of incompatible pathogen infection." [ISBN:0943088399]
synonym: "induction of phytoalexin anabolism" EXACT []
synonym: "induction of phytoalexin biosynthesis" EXACT []
synonym: "induction of phytoalexin formation" EXACT []
synonym: "induction of phytoalexin synthesis" EXACT []
is_a: GO:0009814 ! defense response, incompatible interaction
is_a: GO:0052322 ! positive regulation of phytoalexin biosynthetic process

[Term]
id: GO:0009690
name: cytokinin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845]
subset: gosubset_prok
synonym: "cytokinin metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0009691
name: cytokinin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845]
subset: gosubset_prok
synonym: "cytokinin anabolism" EXACT []
synonym: "cytokinin biosynthesis" EXACT []
synonym: "cytokinin formation" EXACT []
synonym: "cytokinin synthesis" EXACT []
is_a: GO:0009690 ! cytokinin metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0009692
name: ethylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845]
subset: gosubset_prok
synonym: "ethene metabolic process" EXACT []
synonym: "ethene metabolism" EXACT []
synonym: "ethylene metabolism" EXACT []
xref: Reactome:437828 "Ethylene is oxidized to Ethylene oxide by CYP1A1"
xref: Reactome:459950 "Ethylene is oxidized to Ethylene oxide by CYP1A1"
xref: Reactome:479044 "Ethylene is oxidized to Ethylene oxide by CYP1A1"
xref: Reactome:498872 "Ethylene is oxidized to Ethylene oxide by CYP1A1"
xref: Reactome:513405 "Ethylene is oxidized to Ethylene oxide by CYP1A1"
xref: Reactome:522510 "Ethylene is oxidized to Ethylene oxide by CYP1A1"
xref: Reactome:564866 "Ethylene is oxidized to Ethylene oxide by CYP1A1"
xref: Reactome:577285 "Ethylene is oxidized to Ethylene oxide by CYP1A1"
xref: Reactome:76472 "Ethylene is oxidized to Ethylene oxide by CYP1A1"
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0009693
name: ethylene biosynthetic process
namespace: biological_process
alt_id: GO:0042456
def: "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845]
subset: gosubset_prok
synonym: "ethene biosynthesis" EXACT []
synonym: "ethene biosynthesis from L-methionine" EXACT []
synonym: "ethene biosynthetic process" EXACT []
synonym: "ethene biosynthetic process from L-methionine" EXACT []
synonym: "ethylene anabolism" EXACT []
synonym: "ethylene biosynthesis" EXACT []
synonym: "ethylene biosynthesis from L-methionine" EXACT []
synonym: "ethylene biosynthetic process from L-methionine" EXACT []
synonym: "ethylene formation" EXACT []
synonym: "ethylene synthesis" EXACT []
xref: MetaCyc:ETHYL-PWY
is_a: GO:0006555 ! methionine metabolic process
is_a: GO:0009692 ! ethylene metabolic process
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process
is_a: GO:0043450 ! alkene biosynthetic process

[Term]
id: GO:0009694
name: jasmonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving jasmonic acid, a fatty acid derivative with the formula (1R-(1 alpha, 2 beta(Z)))-3-oxo-2-(2-pentenyl)cyclopentaneacetic acid." [ISBN:0387969845]
subset: gosubset_prok
synonym: "jasmonic acid metabolism" EXACT []
is_a: GO:0031407 ! oxylipin metabolic process

[Term]
id: GO:0009695
name: jasmonic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative." [ISBN:0387969845]
synonym: "jasmonic acid anabolism" EXACT []
synonym: "jasmonic acid biosynthesis" EXACT []
synonym: "jasmonic acid formation" EXACT []
synonym: "jasmonic acid synthesis" EXACT []
xref: MetaCyc:PWY-735
is_a: GO:0009694 ! jasmonic acid metabolic process
is_a: GO:0031408 ! oxylipin biosynthetic process

[Term]
id: GO:0009696
name: salicylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399]
subset: gosubset_prok
synonym: "salicylic acid metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0009697
name: salicylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399]
subset: gosubset_prok
synonym: "salicylate biosynthetic process" EXACT []
synonym: "salicylic acid anabolism" EXACT []
synonym: "salicylic acid biosynthesis" EXACT []
synonym: "salicylic acid formation" EXACT []
synonym: "salicylic acid synthesis" EXACT []
xref: MetaCyc:PWY-981
is_a: GO:0009696 ! salicylic acid metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0009698
name: phenylpropanoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid." [GOC:jl]
subset: gosubset_prok
synonym: "phenylpropanoid metabolism" EXACT []
xref: MetaCyc:PWY1F-467
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:0009699
name: phenylpropanoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid." [GOC:jl]
subset: gosubset_prok
synonym: "phenylpropanoid anabolism" EXACT []
synonym: "phenylpropanoid biosynthesis" EXACT []
synonym: "phenylpropanoid formation" EXACT []
synonym: "phenylpropanoid synthesis" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process

[Term]
id: GO:0009700
name: indole phytoalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:sm, ISBN:0198547684]
synonym: "indole phytoalexin anabolism" EXACT []
synonym: "indole phytoalexin biosynthesis" EXACT []
synonym: "indole phytoalexin formation" EXACT []
synonym: "indole phytoalexin synthesis" EXACT []
is_a: GO:0042435 ! indole derivative biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0046217 ! indole phytoalexin metabolic process
is_a: GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0009701
name: isoflavonoid phytoalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai]
synonym: "isoflavonoid phytoalexin anabolism" EXACT []
synonym: "isoflavonoid phytoalexin biosynthesis" EXACT []
synonym: "isoflavonoid phytoalexin formation" EXACT []
synonym: "isoflavonoid phytoalexin synthesis" EXACT []
is_a: GO:0009716 ! flavonoid phytoalexin biosynthetic process
is_a: GO:0009717 ! isoflavonoid biosynthetic process
is_a: GO:0046289 ! isoflavonoid phytoalexin metabolic process

[Term]
id: GO:0009702
name: L-arabinokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-arabinose = ADP + beta-L-arabinose 1-phosphate." [EC:2.7.1.46]
synonym: "ATP:L-arabinose 1-phosphotransferase activity" EXACT []
synonym: "L-arabinokinase (phosphorylating)" EXACT [EC:2.7.1.46]
xref: EC:2.7.1.46
xref: MetaCyc:L-ARABINOKINASE-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0009703
name: nitrate reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NO2- (nitrite) + NAD+ + H2O = NO3- (nitrate) + NADH + H+." [EC:1.7.1.1]
comment: Note that this function was formerly EC:1.6.6.1.
synonym: "assimilatory NADH: nitrate reductase activity" EXACT [EC:1.7.1.1]
synonym: "assimilatory NADH:nitrate reductase activity" EXACT [EC:1.7.1.1]
synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.1]
synonym: "NADH-dependent nitrate reductase activity" EXACT [EC:1.7.1.1]
synonym: "NADH-nitrate reductase activity" EXACT [EC:1.7.1.1]
synonym: "NADH:nitrate oxidoreductase activity" EXACT [EC:1.7.1.1]
synonym: "NADH:nitrate reductase activity" EXACT []
synonym: "nitrate reductase (NADH(2)) activity" EXACT [EC:1.7.1.1]
synonym: "nitrate reductase (NADH2)" EXACT [EC:1.7.1.1]
synonym: "nitrite:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.1]
xref: EC:1.7.1.1
xref: MetaCyc:NITRATE-REDUCTASE-NADH-RXN
is_a: GO:0008940 ! nitrate reductase activity
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0009704
name: de-etiolation
namespace: biological_process
def: "The greening response of plants grown in the dark (etiolated) as a result of chloroplast biogenesis and the accumulation of chlorophyll." [GOC:lr]
is_a: GO:0009416 ! response to light stimulus
relationship: part_of GO:0009640 ! photomorphogenesis

[Term]
id: GO:0009705
name: plant-type vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0471245208]
synonym: "membrane of vacuole with cell cycle-independent morphology" EXACT []
synonym: "tonoplast" EXACT []
synonym: "vacuolar membrane" BROAD []
is_a: GO:0005774 ! vacuolar membrane
relationship: part_of GO:0000325 ! plant-type vacuole

[Term]
id: GO:0009706
name: chloroplast inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma." [GOC:tb]
synonym: "chloroplast inner envelope" EXACT []
is_a: GO:0009528 ! plastid inner membrane
is_a: GO:0031969 ! chloroplast membrane

[Term]
id: GO:0009707
name: chloroplast outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope." [GOC:tb]
synonym: "chloroplast outer envelope" EXACT []
is_a: GO:0009527 ! plastid outer membrane
is_a: GO:0031969 ! chloroplast membrane

[Term]
id: GO:0009708
name: benzyl isoquinoline alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "benzyl isoquinoline alkaloid anabolism" EXACT []
synonym: "benzyl isoquinoline alkaloid biosynthesis" EXACT []
synonym: "benzyl isoquinoline alkaloid formation" EXACT []
synonym: "benzyl isoquinoline alkaloid synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process
is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process

[Term]
id: GO:0009709
name: terpenoid indole alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate)." [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html]
subset: gosubset_prok
synonym: "terpenoid indole alkaloid anabolism" EXACT []
synonym: "terpenoid indole alkaloid biosynthesis" EXACT []
synonym: "terpenoid indole alkaloid formation" EXACT []
synonym: "terpenoid indole alkaloid synthesis" EXACT []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0042434 ! indole derivative metabolic process
is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process

[Term]
id: GO:0009710
name: tropane alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "tropane alkaloid anabolism" EXACT []
synonym: "tropane alkaloid biosynthesis" EXACT []
synonym: "tropane alkaloid formation" EXACT []
synonym: "tropane alkaloid synthesis" EXACT []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0046448 ! tropane alkaloid metabolic process

[Term]
id: GO:0009711
name: purine alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure." [GOC:ai]
subset: gosubset_prok
synonym: "purine alkaloid anabolism" EXACT []
synonym: "purine alkaloid biosynthesis" EXACT []
synonym: "purine alkaloid formation" EXACT []
synonym: "purine alkaloid synthesis" EXACT []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0046446 ! purine alkaloid metabolic process

[Term]
id: GO:0009712
name: catechol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent." [GOC:sm, ISBN:0198547684]
subset: gosubset_prok
synonym: "catechol metabolism" EXACT []
is_a: GO:0018958 ! phenol metabolic process
is_a: GO:0034311 ! diol metabolic process

[Term]
id: GO:0009713
name: catechol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of catechol, a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators]
subset: gosubset_prok
synonym: "catechol anabolism" EXACT []
synonym: "catechol biosynthesis" EXACT []
synonym: "catechol formation" EXACT []
synonym: "catechol synthesis" EXACT []
is_a: GO:0009712 ! catechol metabolic process
is_a: GO:0034312 ! diol biosynthetic process

[Term]
id: GO:0009714
name: chalcone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chalcones, phenyl steryl ketone or its hydroxylated derivatives." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "chalcone metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process

[Term]
id: GO:0009715
name: chalcone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chalcone, phenyl steryl ketone or its hydroxylated derivatives." [GOC:go_curators]
subset: gosubset_prok
synonym: "chalcone anabolism" EXACT []
synonym: "chalcone biosynthesis" EXACT []
synonym: "chalcone formation" EXACT []
synonym: "chalcone synthesis" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009714 ! chalcone metabolic process
is_a: GO:0042181 ! ketone biosynthetic process

[Term]
id: GO:0009716
name: flavonoid phytoalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "flavonoid phytoalexin anabolism" EXACT []
synonym: "flavonoid phytoalexin biosynthesis" EXACT []
synonym: "flavonoid phytoalexin formation" EXACT []
synonym: "flavonoid phytoalexin synthesis" EXACT []
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0046285 ! flavonoid phytoalexin metabolic process
is_a: GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0009717
name: isoflavonoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids." [GOC:ai]
subset: gosubset_prok
synonym: "isoflavonoid anabolism" EXACT []
synonym: "isoflavonoid biosynthesis" EXACT []
synonym: "isoflavonoid formation" EXACT []
synonym: "isoflavonoid synthesis" EXACT []
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0046287 ! isoflavonoid metabolic process

[Term]
id: GO:0009718
name: anthocyanin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins." [GOC:ai]
subset: gosubset_prok
synonym: "anthocyanin anabolism" EXACT []
synonym: "anthocyanin biosynthesis" EXACT []
synonym: "anthocyanin formation" EXACT []
synonym: "anthocyanin synthesis" EXACT []
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0046283 ! anthocyanin metabolic process

[Term]
id: GO:0009719
name: response to endogenous stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm]
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0009720
name: detection of hormone stimulus
namespace: biological_process
def: "The series of events in which a hormone stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of hormone stimulus" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009725 ! response to hormone stimulus
is_a: GO:0009726 ! detection of endogenous stimulus

[Term]
id: GO:0009721
name: detection of auxin stimulus
namespace: biological_process
def: "The series of events in which an auxin stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of auxin stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009733 ! response to auxin stimulus

[Term]
id: GO:0009722
name: detection of cytokinin stimulus
namespace: biological_process
def: "The series of events in which a cytokinin stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of cytokinin stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009735 ! response to cytokinin stimulus

[Term]
id: GO:0009723
name: response to ethylene stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus." [GOC:jl]
synonym: "response to ethene stimulus" EXACT []
is_a: GO:0009725 ! response to hormone stimulus

[Term]
id: GO:0009724
name: detection of abscisic acid stimulus
namespace: biological_process
def: "The series of events in which an abscisic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of abscisic acid stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009737 ! response to abscisic acid stimulus

[Term]
id: GO:0009725
name: response to hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl]
synonym: "growth regulator" RELATED []
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0009726
name: detection of endogenous stimulus
namespace: biological_process
def: "The series of events in which an endogenous stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of endogenous stimulus" RELATED []
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0009727
name: detection of ethylene stimulus
namespace: biological_process
def: "The series of events in which an ethylene (ethene) stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "detection of ethene stimulus" EXACT []
synonym: "perception of ethene stimulus" RELATED []
synonym: "perception of ethylene stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009723 ! response to ethylene stimulus

[Term]
id: GO:0009728
name: detection of gibberellic acid stimulus
namespace: biological_process
def: "The series of events in which a gibberellic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of gibberellic acid stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009739 ! response to gibberellin stimulus

[Term]
id: GO:0009729
name: detection of brassinosteroid stimulus
namespace: biological_process
def: "The series of events in which a brassinosteroid stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of brassinosteroid stimulus" RELATED []
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0009741 ! response to brassinosteroid stimulus

[Term]
id: GO:0009730
name: detection of carbohydrate stimulus
namespace: biological_process
def: "The series of events in which a carbohydrate stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of carbohydrate stimulus" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009743 ! response to carbohydrate stimulus

[Term]
id: GO:0009731
name: detection of sucrose stimulus
namespace: biological_process
def: "The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of sucrose stimulus" RELATED []
is_a: GO:0009744 ! response to sucrose stimulus
is_a: GO:0034288 ! detection of disaccharide stimulus

[Term]
id: GO:0009732
name: detection of hexose stimulus
namespace: biological_process
def: "The series of events in which a stimulus from a hexose is received and converted into a molecular signal." [GOC:sm]
synonym: "perception of hexose stimulus" RELATED []
is_a: GO:0009746 ! response to hexose stimulus
is_a: GO:0034287 ! detection of monosaccharide stimulus

[Term]
id: GO:0009733
name: response to auxin stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus." [GOC:jl]
is_a: GO:0009725 ! response to hormone stimulus

[Term]
id: GO:0009734
name: auxin mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated in response to detection of auxin." [GOC:mah, GOC:sm]
synonym: "auxin mediated signalling" EXACT []
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0023033 ! signaling pathway
is_a: GO:0071365 ! cellular response to auxin stimulus

[Term]
id: GO:0009735
name: response to cytokinin stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus." [GOC:jl]
is_a: GO:0009725 ! response to hormone stimulus

[Term]
id: GO:0009736
name: cytokinin mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals induced by the detection of cytokinin." [GOC:sm]
synonym: "cytokinin mediated signalling" EXACT []
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0071368 ! cellular response to cytokinin stimulus

[Term]
id: GO:0009737
name: response to abscisic acid stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:jl]
is_a: GO:0009725 ! response to hormone stimulus

[Term]
id: GO:0009738
name: abscisic acid mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by the detection of abscisic acid." [GOC:sm]
synonym: "abscisic acid mediated signalling" EXACT []
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0071215 ! cellular response to abscisic acid stimulus

[Term]
id: GO:0009739
name: response to gibberellin stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:jl]
synonym: "response to gibberellic acid stimulus" NARROW []
is_a: GO:0009725 ! response to hormone stimulus

[Term]
id: GO:0009740
name: gibberellic acid mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by the detection of gibberellic acid." [GOC:sm]
synonym: "GA-signaling" EXACT []
synonym: "gibberellic acid mediated signalling" EXACT []
synonym: "gibberellic acid signaling" EXACT []
is_a: GO:0010476 ! gibberellin mediated signaling pathway
is_a: GO:0071370 ! cellular response to gibberellin stimulus

[Term]
id: GO:0009741
name: response to brassinosteroid stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus." [GOC:jl]
is_a: GO:0009725 ! response to hormone stimulus

[Term]
id: GO:0009742
name: brassinosteroid mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by the detection of brassinosteroid." [GOC:sm]
synonym: "brassinosteroid mediated signalling" EXACT []
is_a: GO:0043401 ! steroid hormone mediated signaling pathway
is_a: GO:0071367 ! cellular response to brassinosteroid stimulus

[Term]
id: GO:0009743
name: response to carbohydrate stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:jl]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0009744
name: response to sucrose stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl]
is_a: GO:0034285 ! response to disaccharide stimulus

[Term]
id: GO:0009745
name: sucrose mediated signaling
namespace: biological_process
def: "A series of molecular signals mediated by the detection of sucrose." [GOC:sm]
synonym: "sucrose mediated signalling" EXACT []
is_a: GO:0010182 ! sugar mediated signaling pathway
is_a: GO:0071329 ! cellular response to sucrose stimulus

[Term]
id: GO:0009746
name: response to hexose stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:jl]
is_a: GO:0034284 ! response to monosaccharide stimulus

[Term]
id: GO:0009747
name: hexokinase-dependent signaling
namespace: biological_process
def: "A series of molecular signals mediated by hexose and dependent on the detection of hexokinase." [GOC:mah, GOC:sm]
synonym: "hexokinase-dependent signalling" EXACT []
is_a: GO:0009757 ! hexose mediated signaling

[Term]
id: GO:0009748
name: hexokinase-independent signaling
namespace: biological_process
def: "A series of molecular signals mediated by hexose and independent of hexokinase." [GOC:mah, GOC:sm]
synonym: "hexokinase-independent signalling" EXACT []
is_a: GO:0009757 ! hexose mediated signaling

[Term]
id: GO:0009749
name: response to glucose stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:jl]
is_a: GO:0009746 ! response to hexose stimulus

[Term]
id: GO:0009750
name: response to fructose stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:jl]
is_a: GO:0009746 ! response to hexose stimulus

[Term]
id: GO:0009751
name: response to salicylic acid stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:jl]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0009752
name: detection of salicylic acid stimulus
namespace: biological_process
def: "The series of events in which a salicylic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "perception of salicylic acid stimulus" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009751 ! response to salicylic acid stimulus

[Term]
id: GO:0009753
name: response to jasmonic acid stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:jl]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0009754
name: detection of jasmonic acid stimulus
namespace: biological_process
def: "The series of events in which a jasmonic acid stimulus is received by a cell and converted into a molecular signal. Series of events required for a jasmonic acid stimulus to be detected and converted to a signal molecule." [GOC:sm]
synonym: "perception of jasmonic acid stimulus" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009726 ! detection of endogenous stimulus
is_a: GO:0009753 ! response to jasmonic acid stimulus

[Term]
id: GO:0009755
name: hormone-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by the detection of a hormone." [GOC:sm]
synonym: "hormone mediated signalling" EXACT []
xref: Reactome:163359 "Glucagon signaling in metabolic regulation"
xref: Reactome:448643 "Glucagon signaling in metabolic regulation"
xref: Reactome:469771 "Glucagon signaling in metabolic regulation"
xref: Reactome:487465 "Glucagon signaling in metabolic regulation"
xref: Reactome:507425 "Glucagon signaling in metabolic regulation"
xref: Reactome:517428 "Glucagon signaling in metabolic regulation"
xref: Reactome:526302 "Glucagon signaling in metabolic regulation"
xref: Reactome:531302 "Glucagon signaling in metabolic regulation"
xref: Reactome:536676 "Glucagon signaling in metabolic regulation"
xref: Reactome:542409 "Glucagon signaling in metabolic regulation"
xref: Reactome:547758 "Glucagon signaling in metabolic regulation"
xref: Reactome:557935 "Glucagon signaling in metabolic regulation"
xref: Reactome:592683 "Glucagon signaling in metabolic regulation"
xref: Reactome:595440 "Glucagon signaling in metabolic regulation"
is_a: GO:0007242 ! intracellular signaling cascade
is_a: GO:0032870 ! cellular response to hormone stimulus

[Term]
id: GO:0009756
name: carbohydrate mediated signaling
namespace: biological_process
def: "A series of molecular signals mediated by the detection of carbohydrate." [GOC:sm]
synonym: "carbohydrate mediated signalling" EXACT []
is_a: GO:0007242 ! intracellular signaling cascade
is_a: GO:0071322 ! cellular response to carbohydrate stimulus

[Term]
id: GO:0009757
name: hexose mediated signaling
namespace: biological_process
def: "A series of molecular signals mediated by the detection of hexose." [GOC:sm]
synonym: "hexose mediated signalling" EXACT []
is_a: GO:0010182 ! sugar mediated signaling pathway
is_a: GO:0071331 ! cellular response to hexose stimulus

[Term]
id: GO:0009758
name: carbohydrate utilization
namespace: biological_process
def: "Series of processes that involve carbohydrate sensing, carbohydrate transportation and carbohydrate metabolism which lead to the utilization of carbohydrates." [GOC:sm]
is_a: GO:0009743 ! response to carbohydrate stimulus

[Term]
id: GO:0009759
name: indole glucosinolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [GOC:ai]
subset: gosubset_prok
synonym: "indole glucosinolate anabolism" EXACT []
synonym: "indole glucosinolate biosynthesis" EXACT []
synonym: "indole glucosinolate formation" EXACT []
synonym: "indole glucosinolate synthesis" EXACT []
xref: MetaCyc:PWY-601
is_a: GO:0019761 ! glucosinolate biosynthetic process
is_a: GO:0042343 ! indole glucosinolate metabolic process
is_a: GO:0042435 ! indole derivative biosynthetic process

[Term]
id: GO:0009760
name: C4 photosynthesis
namespace: biological_process
def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) in the mesophyll cells to make a 4-carbon acid which is immediately converted to malic acid. The malic acid is then passed across to the bundle sheath cells where it is broken down again to pyruvic acid and CO2. The acid is passed back to the mesophyll cells to be used again, while the CO2 is fed into the reductive pentose-phosphate cycle (Calvin cycle) and converted into sugar and starch." [ISBN:0816017360]
xref: Wikipedia:C4_carbon_fixation
is_a: GO:0015977 ! carbon utilization by fixation of carbon dioxide
is_a: GO:0019685 ! photosynthesis, dark reaction
is_a: GO:0044236 ! multicellular organismal metabolic process

[Term]
id: GO:0009761
name: CAM photosynthesis
namespace: biological_process
def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) to make malic acid. The malic acid is then passed into the vacuole where it is stored until daylight, when it is shuttled back out to be used as a substrate in the light reaction of photosynthesis." [ISBN:0582015952]
xref: Wikipedia:Crassulacean_acid_metabolism
is_a: GO:0015977 ! carbon utilization by fixation of carbon dioxide
is_a: GO:0019685 ! photosynthesis, dark reaction

[Term]
id: GO:0009762
name: NADP-malic enzyme C4 photosynthesis
namespace: biological_process
def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NADP-malic enzyme." [PMID:11788762]
xref: MetaCyc:PWY-241
is_a: GO:0009760 ! C4 photosynthesis

[Term]
id: GO:0009763
name: NAD-malic enzyme C4 photosynthesis
namespace: biological_process
def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NAD-malic enzyme." [PMID:11788762]
is_a: GO:0009760 ! C4 photosynthesis

[Term]
id: GO:0009764
name: PEP carboxykinase C4 photosynthesis
namespace: biological_process
def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is phosphoenolpyruvate carboxykinase (PEPCK)." [PMID:11788762]
is_a: GO:0009760 ! C4 photosynthesis

[Term]
id: GO:0009765
name: photosynthesis, light harvesting
namespace: biological_process
def: "Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers." [GOC:sm]
synonym: "energy dissipation" RELATED []
is_a: GO:0006091 ! generation of precursor metabolites and energy
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0009766
name: primary charge separation
namespace: biological_process
def: "In the photosynthetic reaction centers, primary charge separation is initiated by the excitation of a molecule followed by the transfer of an electron to an electron acceptor molecule following energy transfer from light harvesting complexes." [ISBN:0792361431]
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0009767
name: photosynthetic electron transport chain
namespace: biological_process
def: "A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0198547684]
synonym: "electron carrier, chlorophyll electron transport system" EXACT []
is_a: GO:0022900 ! electron transport chain
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0009768
name: photosynthesis, light harvesting in photosystem I
namespace: biological_process
def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem I, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jic, ISBN:0716731363, ISBN:0816017360]
is_a: GO:0009765 ! photosynthesis, light harvesting

[Term]
id: GO:0009769
name: photosynthesis, light harvesting in photosystem II
namespace: biological_process
def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem II, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jic, ISBN:0716731363, ISBN:0816017360]
is_a: GO:0009765 ! photosynthesis, light harvesting

[Term]
id: GO:0009770
name: primary charge separation in photosystem I
namespace: biological_process
def: "Energized reaction-center P700 chlorophylls on photosystem I donate an electron to a loosely bound Quinone acceptor molecule X, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jic, ISBN:0716731363, ISBN:0816017360]
is_a: GO:0009766 ! primary charge separation

[Term]
id: GO:0009771
name: primary charge separation in photosystem II
namespace: biological_process
def: "Energized reaction-center P680 chlorophylls on photosystem II donate an electron to a loosely bound acceptor molecule, the quinone Q, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jic, ISBN:0716731363, ISBN:0816017360]
is_a: GO:0009766 ! primary charge separation

[Term]
id: GO:0009772
name: photosynthetic electron transport in photosystem II
namespace: biological_process
def: "Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I." [GOC:jic, ISBN:0716731363, ISBN:0816017360]
is_a: GO:0009767 ! photosynthetic electron transport chain

[Term]
id: GO:0009773
name: photosynthetic electron transport in photosystem I
namespace: biological_process
def: "Electrons move from the primary electron acceptor (Quinone, X) through a chain of electron transport molecules in the thylakoid membrane until they reach ferredoxin which passes the electron to the ultimate electron acceptor; NADP." [GOC:jic, ISBN:0716731363, ISBN:0816017360]
is_a: GO:0009767 ! photosynthetic electron transport chain

[Term]
id: GO:0009774
name: photosynthetic electron transport in plastoquinone
namespace: biological_process
is_a: GO:0009767 ! photosynthetic electron transport chain

[Term]
id: GO:0009775
name: photosynthetic electron transport in cytochrome b6/f
namespace: biological_process
is_a: GO:0009767 ! photosynthetic electron transport chain

[Term]
id: GO:0009776
name: photosynthetic electron transport in plastocyanin
namespace: biological_process
is_a: GO:0009767 ! photosynthetic electron transport chain

[Term]
id: GO:0009777
name: photosynthetic phosphorylation
namespace: biological_process
def: "Any metabolic process by which photosynthetic organisms use light energy to convert ADP to ATP without the concomitant reduction of dioxygen (O2) to water that occurs in phosphorylation." [ISBN:0198547684]
synonym: "photosynthetic ATP synthesis" NARROW []
is_a: GO:0016310 ! phosphorylation
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0009778
name: cyclic photosynthetic phosphorylation
namespace: biological_process
def: "ATP synthesis is driven by a proton gradient generated across the thylakoid membrane. Involves only photosystem I." [ISBN:0198547684]
is_a: GO:0009777 ! photosynthetic phosphorylation

[Term]
id: GO:0009779
name: noncyclic photosynthetic phosphorylation
namespace: biological_process
def: "ATP synthesis is linked to the transport of electrons from water to NADP+ with the production of NADPH and dioxygen (O2). Involves photosystem I and photosystem II." [ISBN:0198547684]
is_a: GO:0009777 ! photosynthetic phosphorylation

[Term]
id: GO:0009780
name: photosynthetic NADP+ reduction
namespace: biological_process
def: "The process by which NADP+ is reduced to NADPH. The light reactions of photosynthesis use energy from photons to generate high-energy electrons. These electrons are used directly to reduce NADP+ to NADPH. NADPH is a relatively stable molecule and can pass on its hydrogen atom to other molecules in chemical reactions." [GOC:jic, ISBN:0716746840, ISBN:0816017360]
is_a: GO:0006740 ! NADPH regeneration
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0009781
name: photosynthetic water oxidation
namespace: biological_process
def: "OBSOLETE. Processes by which a molecule of water is oxidized during photosynthesis. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:jic, ISBN:0716743663, ISBN:0816017360]
comment: This term was made obsolete because it represents a molecular function.
is_obsolete: true
replaced_by: GO:0010242

[Term]
id: GO:0009782
name: photosystem I antenna complex
namespace: cellular_component
def: "The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jic, ISBN:0716731363]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0009522 ! photosystem I

[Term]
id: GO:0009783
name: photosystem II antenna complex
namespace: cellular_component
def: "The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jic, ISBN:0716731363]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0009523 ! photosystem II

[Term]
id: GO:0009784
name: transmembrane receptor histidine kinase activity
namespace: molecular_function
def: "A transmembrane receptor that perceives a stimulus and that produces a molecular signal via phosphotransfer at histidine residues." [GOC:lr]
subset: gosubset_prok
is_a: GO:0004673 ! protein histidine kinase activity
is_a: GO:0019199 ! transmembrane receptor protein kinase activity

[Term]
id: GO:0009785
name: blue light signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm." [GOC:lr, GOC:sm]
synonym: "blue light signalling pathway" EXACT []
is_a: GO:0007242 ! intracellular signaling cascade
is_a: GO:0071483 ! cellular response to blue light

[Term]
id: GO:0009786
name: regulation of asymmetric cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr]
is_a: GO:0051302 ! regulation of cell division
relationship: regulates GO:0008356 ! asymmetric cell division

[Term]
id: GO:0009787
name: regulation of abscisic acid mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by abscisic acid." [GOC:lr]
synonym: "regulation of abscisic acid mediated signalling" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0009738 ! abscisic acid mediated signaling pathway

[Term]
id: GO:0009788
name: negative regulation of abscisic acid mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by abscisic acid." [GOC:lr]
synonym: "down regulation of abscisic acid mediated signaling" EXACT []
synonym: "down-regulation of abscisic acid mediated signaling" EXACT []
synonym: "downregulation of abscisic acid mediated signaling" EXACT []
synonym: "inhibition of abscisic acid mediated signaling" NARROW []
synonym: "negative regulation of abscisic acid mediated signalling" EXACT []
is_a: GO:0009787 ! regulation of abscisic acid mediated signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0009738 ! abscisic acid mediated signaling pathway

[Term]
id: GO:0009789
name: positive regulation of abscisic acid mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of abscisic acid mediated signal transduction." [GOC:lr]
synonym: "activation of abscisic acid mediated signaling" NARROW []
synonym: "positive regulation of abscisic acid mediated signalling" EXACT []
synonym: "stimulation of abscisic acid mediated signaling" NARROW []
synonym: "up regulation of abscisic acid mediated signaling" EXACT []
synonym: "up-regulation of abscisic acid mediated signaling" EXACT []
synonym: "upregulation of abscisic acid mediated signaling" EXACT []
is_a: GO:0009787 ! regulation of abscisic acid mediated signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0009738 ! abscisic acid mediated signaling pathway

[Term]
id: GO:0009790
name: embryonic development
namespace: biological_process
alt_id: GO:0009795
def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
subset: goslim_generic
subset: goslim_plant
synonym: "embryogenesis" EXACT []
synonym: "embryogenesis and morphogenesis" BROAD []
synonym: "embryonal development" EXACT []
xref: Wikipedia:Embryogenesis
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0009791
name: post-embryonic development
namespace: biological_process
def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators]
subset: goslim_plant
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0009792
name: embryonic development ending in birth or egg hatching
namespace: biological_process
def: "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
synonym: "embryogenesis" BROAD []
is_a: GO:0009790 ! embryonic development

[Term]
id: GO:0009793
name: embryonic development ending in seed dormancy
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana." [GOC:go_curators, GOC:mtg_sensu]
synonym: "embryogenesis" BROAD []
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0009790 ! embryonic development
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0009794
name: regulation of mitotic cell cycle, embryonic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "control of embryonic mitotic cell cycle progression" EXACT []
synonym: "embryonic mitotic cell cycle control" EXACT []
synonym: "embryonic mitotic cell cycle modulation" EXACT []
synonym: "embryonic mitotic cell cycle regulation" EXACT []
synonym: "embryonic mitotic cell cycle regulator" RELATED []
synonym: "modulation of embryonic mitotic cell cycle progression" EXACT []
synonym: "regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of embryonic mitotic cell cycle progression" EXACT []
synonym: "regulation of progression through embryonic mitotic cell cycle" EXACT []
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0045995 ! regulation of embryonic development
relationship: regulates GO:0045448 ! mitotic cell cycle, embryonic

[Term]
id: GO:0009798
name: axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete]
synonym: "axis determination" RELATED []
is_a: GO:0007389 ! pattern specification process

[Term]
id: GO:0009799
name: specification of symmetry
namespace: biological_process
def: "The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created." [GOC:go_curators]
synonym: "determination of symmetry" RELATED [GOC:dph]
is_a: GO:0007389 ! pattern specification process

[Term]
id: GO:0009800
name: cinnamic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl]
subset: gosubset_prok
synonym: "cinnamic acid anabolism" EXACT []
synonym: "cinnamic acid biosynthesis" EXACT []
synonym: "cinnamic acid formation" EXACT []
synonym: "cinnamic acid synthesis" EXACT []
synonym: "cinnamylic acid biosynthesis" EXACT []
synonym: "cinnamylic acid biosynthetic process" EXACT []
synonym: "phenylacrylic acid biosynthesis" EXACT []
synonym: "phenylacrylic acid biosynthetic process" EXACT []
synonym: "phenylpropenoic acid biosynthesis" EXACT []
synonym: "phenylpropenoic acid biosynthetic process" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009803 ! cinnamic acid metabolic process

[Term]
id: GO:0009801
name: cinnamic acid ester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:lr, GOC:yl]
subset: gosubset_prok
synonym: "cinnamic acid ester metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process

[Term]
id: GO:0009802
name: cinnamic acid ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:jl]
subset: gosubset_prok
synonym: "cinnamic acid ester anabolism" EXACT []
synonym: "cinnamic acid ester biosynthesis" EXACT []
synonym: "cinnamic acid ester formation" EXACT []
synonym: "cinnamic acid ester synthesis" EXACT []
synonym: "cinnamylic acid ester biosynthesis" EXACT []
synonym: "cinnamylic acid ester biosynthetic process" EXACT []
synonym: "phenylacrylic acid ester biosynthesis" EXACT []
synonym: "phenylacrylic acid ester biosynthetic process" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009801 ! cinnamic acid ester metabolic process
relationship: part_of GO:0009803 ! cinnamic acid metabolic process

[Term]
id: GO:0009803
name: cinnamic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl]
subset: gosubset_prok
synonym: "cinnamic acid metabolism" EXACT []
synonym: "cinnamylic acid metabolic process" EXACT []
synonym: "cinnamylic acid metabolism" EXACT []
synonym: "phenylacrylic acid metabolic process" EXACT []
synonym: "phenylacrylic acid metabolism" EXACT []
synonym: "phenylpropenoic acid metabolic process" EXACT []
synonym: "phenylpropenoic acid metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0009804
name: coumarin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl]
subset: gosubset_prok
synonym: "coumarin metabolism" EXACT []
xref: Reactome:211881 "Coumarin is 7-hydroxylated by CYP2A13"
xref: Reactome:435417 "Coumarin is 7-hydroxylated by CYP2A13"
xref: Reactome:435423 "Coumarin is 7-hydroxylated by CYP2A6"
xref: Reactome:457813 "Coumarin is 7-hydroxylated by CYP2A13"
xref: Reactome:457819 "Coumarin is 7-hydroxylated by CYP2A6"
xref: Reactome:521405 "Coumarin is 7-hydroxylated by CYP2A13"
xref: Reactome:521408 "Coumarin is 7-hydroxylated by CYP2A6"
xref: Reactome:76453 "Coumarin is 7-hydroxylated by CYP2A6"
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0009805
name: coumarin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl]
subset: gosubset_prok
synonym: "coumarin anabolism" EXACT []
synonym: "coumarin biosynthesis" EXACT []
synonym: "coumarin formation" EXACT []
synonym: "coumarin synthesis" EXACT []
xref: MetaCyc:PWY-5176
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009804 ! coumarin metabolic process

[Term]
id: GO:0009806
name: lignan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466]
subset: gosubset_prok
synonym: "lignan metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process

[Term]
id: GO:0009807
name: lignan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466]
subset: gosubset_prok
synonym: "lignan anabolism" EXACT []
synonym: "lignan biosynthesis" EXACT []
synonym: "lignan formation" EXACT []
synonym: "lignan synthesis" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009806 ! lignan metabolic process

[Term]
id: GO:0009808
name: lignin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lignins, a class of polymers of phenylpropanoid units." [GOC:lr, GOC:yl]
subset: gosubset_prok
synonym: "lignin metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process

[Term]
id: GO:0009809
name: lignin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers." [GOC:tair_curators, ISBN:0198547684]
subset: gosubset_prok
synonym: "lignin anabolism" EXACT []
synonym: "lignin biosynthesis" EXACT []
synonym: "lignin formation" EXACT []
synonym: "lignin synthesis" EXACT []
xref: MetaCyc:PWY-361
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009808 ! lignin metabolic process

[Term]
id: GO:0009810
name: stilbene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving stilbenes, a class of polyketides formed from a molecule of cinnamic acid and three molecules of malonyl-CoA." [ISBN:311011625]
subset: gosubset_prok
synonym: "stilbene metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0009811
name: stilbene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA." [GOC:tair_curators, ISBN:3110116251]
subset: gosubset_prok
synonym: "stilbene anabolism" EXACT []
synonym: "stilbene biosynthesis" EXACT []
synonym: "stilbene formation" EXACT []
synonym: "stilbene synthesis" EXACT []
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009810 ! stilbene metabolic process
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0043450 ! alkene biosynthetic process

[Term]
id: GO:0009812
name: flavonoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins." [GOC:tair_curators, ISBN:0198547684]
subset: gosubset_prok
synonym: "flavonoid metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process

[Term]
id: GO:0009813
name: flavonoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GOC:tair_curators, ISBN:0198547684]
subset: gosubset_prok
synonym: "flavonoid anabolism" EXACT []
synonym: "flavonoid biosynthesis" EXACT []
synonym: "flavonoid formation" EXACT []
synonym: "flavonoid synthesis" EXACT []
xref: MetaCyc:PWY1F-FLAVSYN
xref: Wikipedia:Flavonoid
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0009812 ! flavonoid metabolic process

[Term]
id: GO:0009814
name: defense response, incompatible interaction
namespace: biological_process
def: "A response of a plant to a pathogenic agent that prevents the occurrence or spread of disease." [GOC:lr]
synonym: "defence response incompatible interaction" EXACT []
synonym: "defence response to pathogen, incompatible interaction" EXACT []
synonym: "resistance response to pathogen" EXACT []
synonym: "response to pathogen (incompatible interaction)" EXACT []
is_a: GO:0045087 ! innate immune response
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0009815
name: 1-aminocyclopropane-1-carboxylate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: ascorbate + 1-aminocyclopropane-1-carboxylate + O2 = 2 H2O + ethene (ethylene) + L-dehydro-ascorbate + hydrocyanic acid + CO2." [EC:1.14.17.4, MetaCyc:ETHYL-RXN]
synonym: "1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)" EXACT [EC:1.14.17.4]
synonym: "ACC oxidase activity" EXACT []
synonym: "aminocyclopropanecarboxylate oxidase activity" EXACT [EC:1.14.17.4]
synonym: "ethene-forming enzyme" BROAD []
synonym: "ethylene-forming enzyme" BROAD []
xref: EC:1.14.17.4
xref: MetaCyc:ETHYL-RXN
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0009816
name: defense response to bacterium, incompatible interaction
namespace: biological_process
def: "A response of an organism to a bacterium that prevents the occurrence or spread of disease." [GOC:lr]
synonym: "defence response to bacterium, incompatible interaction" EXACT []
synonym: "defence response to pathogenic bacteria, incompatible interaction" EXACT []
synonym: "defence response to pathogenic bacterium, incompatible interaction" EXACT []
synonym: "resistance response to pathogenic bacteria" EXACT []
synonym: "resistance response to pathogenic bacterium" EXACT []
synonym: "response to pathogenic bacteria (incompatible interaction)" EXACT []
synonym: "response to pathogenic bacterium (incompatible interaction)" EXACT []
is_a: GO:0009814 ! defense response, incompatible interaction
is_a: GO:0042742 ! defense response to bacterium

[Term]
id: GO:0009817
name: defense response to fungus, incompatible interaction
namespace: biological_process
def: "A response of an organism to a fungus that prevents the occurrence or spread of disease." [GOC:lr]
synonym: "defence response to fungus, incompatible interaction" EXACT []
synonym: "defence response to pathogenic fungi, incompatible interaction" EXACT []
synonym: "defence response to pathogenic fungus, incompatible interaction" EXACT []
synonym: "defense response to fungi, incompatible interaction" EXACT []
synonym: "resistance response to pathogenic fungi" EXACT []
synonym: "resistance response to pathogenic fungus" EXACT []
synonym: "response to pathogenic fungi (incompatible interaction)" EXACT []
synonym: "response to pathogenic fungus (incompatible interaction)" EXACT []
is_a: GO:0009814 ! defense response, incompatible interaction
is_a: GO:0050832 ! defense response to fungus

[Term]
id: GO:0009818
name: defense response to protozoan, incompatible interaction
namespace: biological_process
def: "A response of an organism to a protozoan that prevents the occurrence or spread of disease." [GOC:lr]
synonym: "defence response to pathogenic protozoa, incompatible interaction" EXACT []
synonym: "defence response to pathogenic protozoan, incompatible interaction" EXACT []
synonym: "defence response to protozoan, incompatible interaction" EXACT []
synonym: "resistance response to pathogenic protozoa" EXACT []
synonym: "resistance response to pathogenic protozoan" EXACT []
synonym: "response to pathogenic protozoa (incompatible interaction)" EXACT []
synonym: "response to pathogenic protozoan (incompatible interaction)" EXACT []
is_a: GO:0009814 ! defense response, incompatible interaction
is_a: GO:0042832 ! defense response to protozoan

[Term]
id: GO:0009819
name: drought recovery
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, gene expression, enzyme production, etc.) as a result of prolonged deprivation of water that restores that organism to a normal (non-stressed) condition." [GOC:lr]
synonym: "drought tolerance" RELATED []
is_a: GO:0009414 ! response to water deprivation

[Term]
id: GO:0009820
name: alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743]
subset: gosubset_prok
synonym: "alkaloid metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:0009821
name: alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." [EC:1.1.1.51, GOC:lr, ISBN:0122146743]
subset: gosubset_prok
synonym: "alkaloid anabolism" EXACT []
synonym: "alkaloid biosynthesis" EXACT []
synonym: "alkaloid formation" EXACT []
synonym: "alkaloid synthesis" EXACT []
xref: UM-BBD_enzymeID:e0711
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process

[Term]
id: GO:0009822
name: alkaloid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:01221146743]
subset: gosubset_prok
synonym: "alkaloid breakdown" EXACT []
synonym: "alkaloid catabolism" EXACT []
synonym: "alkaloid degradation" EXACT []
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process

[Term]
id: GO:0009823
name: cytokinin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cytokinins, a class of adenine-derived compounds that can function in plants as plant growth regulators." [GOC:lr]
subset: gosubset_prok
synonym: "cytokinin breakdown" EXACT []
synonym: "cytokinin catabolism" EXACT []
synonym: "cytokinin degradation" EXACT []
is_a: GO:0009690 ! cytokinin metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0009824
name: adenylate dimethylallyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: delta(2)-isopentenyl diphosphate + AMP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-monophosphate." [EC:2.5.1.27]
synonym: "2-isopentenyl-diphosphate:AMP 2-isopentenyltransferase activity" EXACT []
synonym: "2-isopentenyl-diphosphate:AMP delta2-isopentenyltransferase activity" EXACT [EC:2.5.1.27]
synonym: "adenylate isopentenyltransferase activity" EXACT []
synonym: "cytokinin synthase activity" EXACT []
synonym: "dimethylallyl-diphosphate:AMP dimethylallyltransferase activity" EXACT [EC:2.5.1.27]
synonym: "isopentenyltransferase activity" EXACT []
xref: EC:2.5.1.27
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0009825
name: multidimensional cell growth
namespace: biological_process
def: "The process by which a cell irreversibly increases in size in two or three [spatial] dimensions or along two or three axes." [ISBN:0943088399]
subset: gosubset_prok
synonym: "cell growth in three dimensions" EXACT []
synonym: "cell growth in two dimensions" NARROW []
is_a: GO:0016049 ! cell growth

[Term]
id: GO:0009826
name: unidimensional cell growth
namespace: biological_process
def: "The process by which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell." [ISBN:0943088399]
subset: gosubset_prok
synonym: "cell elongation" NARROW []
synonym: "cell growth along one axis" EXACT []
synonym: "cell growth in one dimension" EXACT []
synonym: "cell morphogenesis by unidimensional growth" EXACT [GOC:dph, GOC:tb]
synonym: "polar cell growth" EXACT []
synonym: "polarized cell growth" EXACT []
is_a: GO:0000902 ! cell morphogenesis
is_a: GO:0016049 ! cell growth
is_a: GO:0060560 ! developmental growth involved in morphogenesis

[Term]
id: GO:0009827
name: plant-type cell wall modification
namespace: biological_process
def: "The series of events leading to chemical and structural alterations of an existing cellulose and pectin-containing cell wall that can result in loosening, increased extensibility or disassembly. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
synonym: "cellulose and pectin-containing cell wall modification" EXACT []
is_a: GO:0009664 ! plant-type cell wall organization
is_a: GO:0042545 ! cell wall modification

[Term]
id: GO:0009828
name: plant-type cell wall loosening
namespace: biological_process
def: "The series of events causing chemical and structural alterations of an existing cellulose and pectin-containing cell wall that results in greater extensibility of the wall. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
synonym: "cellulose and pectin-containing cell wall loosening" EXACT []
is_a: GO:0009827 ! plant-type cell wall modification

[Term]
id: GO:0009829
name: cell wall modification during ripening
namespace: biological_process
def: "The series of events that occur during ripening that result in chemical or structural alterations of existing cell walls." [GOC:lr]
is_a: GO:0009827 ! plant-type cell wall modification
relationship: part_of GO:0009835 ! ripening

[Term]
id: GO:0009830
name: cell wall modification during abscission
namespace: biological_process
def: "A cellular process that results in the breakdown of the cell wall that contributes to the process of abscission." [GOC:dph, GOC:lr, GOC:sdb_2009, GOC:tb]
is_a: GO:0009827 ! plant-type cell wall modification
is_a: GO:0060871 ! cellular cell wall disassembly
relationship: part_of GO:0009838 ! abscission

[Term]
id: GO:0009831
name: plant-type cell wall modification during multidimensional cell growth
namespace: biological_process
def: "The series of events that occur during cell growth that result in chemical or structural changes to existing cell walls of the type composed chiefly of cellulose and pectin. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
synonym: "cell wall modification during cell expansion" BROAD []
synonym: "cellulose and pectin-containing cell wall modification during multidimensional cell growth" EXACT []
is_a: GO:0009827 ! plant-type cell wall modification
is_a: GO:0042547 ! cell wall modification during multidimensional cell growth

[Term]
id: GO:0009832
name: plant-type cell wall biogenesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana." [GOC:go_curators, GOC:lr, GOC:mtg_sensu]
synonym: "cell wall anabolism" BROAD []
synonym: "cell wall assembly" BROAD []
synonym: "cell wall biosynthetic process" BROAD []
synonym: "cell wall formation" BROAD []
synonym: "cell wall synthesis" BROAD []
synonym: "cellulose and pectin-containing cell wall biogenesis" EXACT []
is_a: GO:0042546 ! cell wall biogenesis
is_a: GO:0071669 ! plant-type cell wall organization or biogenesis

[Term]
id: GO:0009833
name: primary cell wall biogenesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cellulose and pectin-containing cell walls that form adjacent to the middle lamella following cell division and during cell expansion. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
synonym: "cellulose and pectin-containing primary cell wall biogenesis" EXACT []
synonym: "plant-type primary cell wall biogenesis" EXACT []
synonym: "primary cell wall anabolism" BROAD []
synonym: "primary cell wall biosynthetic process" BROAD []
synonym: "primary cell wall formation" BROAD []
synonym: "primary cell wall synthesis" BROAD []
is_a: GO:0009832 ! plant-type cell wall biogenesis

[Term]
id: GO:0009834
name: secondary cell wall biogenesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of inextensible cellulose and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu]
synonym: "cellulose and pectin-containing secondary cell wall biogenesis" EXACT []
synonym: "plant-type secondary cell wall biogenesis" EXACT []
synonym: "secondary cell wall anabolism" BROAD []
synonym: "secondary cell wall biosynthetic process" BROAD []
synonym: "secondary cell wall formation" BROAD []
synonym: "secondary cell wall synthesis" BROAD []
is_a: GO:0009832 ! plant-type cell wall biogenesis

[Term]
id: GO:0009835
name: ripening
namespace: biological_process
def: "The series of events causing changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) to make it more attractive to animals and/or aid in seed dispersal." [GOC:lr]
subset: goslim_plant
xref: Wikipedia:Ripening
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0009836
name: ripening, climacteric
namespace: biological_process
def: "A ripening process that involves a burst of respiration and ethylene (ethene) evolution at the onset." [GOC:lr, ISBN:0521587840]
is_a: GO:0009835 ! ripening

[Term]
id: GO:0009837
name: ripening, non-climacteric
namespace: biological_process
def: "A ripening process that does not involve a respiratory burst." [GOC:lr, ISBN:0521587840]
is_a: GO:0009835 ! ripening

[Term]
id: GO:0009838
name: abscission
namespace: biological_process
def: "The controlled shedding of a body part." [ISBN:0140514031]
subset: goslim_plant
xref: Wikipedia:Abscission
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0009839
name: SCF complex substrate recognition subunit
namespace: cellular_component
def: "OBSOLETE. The portion of the SCF ubiquitin ligase complex that contains sites required for recognition (and recruitment) of the substrate to the complex." [PMID:11790542, PMID:9857172]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
replaced_by: GO:0019005

[Term]
id: GO:0009840
name: chloroplastic endopeptidase Clp complex
namespace: cellular_component
def: "A Clp endopeptidase complex located in the chloroplast." [GOC:mah]
is_a: GO:0009368 ! endopeptidase Clp complex
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0009841
name: mitochondrial endopeptidase Clp complex
namespace: cellular_component
def: "A Clp endopeptidase complex located in the mitochondrion." [GOC:mah]
is_a: GO:0009368 ! endopeptidase Clp complex
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0009842
name: cyanelle
namespace: cellular_component
def: "A plastid that contains unstacked, phycobilisome-bearing thylakoid membranes and is surrounded by a peptidoglycan layer as well as a double membrane. Cyanelles are characteristic of algae in the class Glaucophyta, and may represent an ancestral form of plastid." [ISBN:052131687, ISBN:1402001894]
subset: gosubset_prok
synonym: "cyanoplast" EXACT [ISBN:1402001894]
synonym: "muroplast" EXACT [ISBN:1402001894]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0009843
name: cyanelle thylakoid
namespace: cellular_component
def: "A thylakoid found in a cyanelle, which is a type of plastid found in certain algae. The cyanelle contains a photosynthetic membrane resembling that of cyanobacteria." [GOC:lr, GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
is_a: GO:0031976 ! plastid thylakoid
relationship: part_of GO:0009842 ! cyanelle

[Term]
id: GO:0009844
name: germination
namespace: biological_process
alt_id: GO:0009565
def: "OBSOLETE. The physiological and developmental changes by a seed, spore, pollen grain (microspore), or zygote that occur after release from dormancy, and encompassing events prior to and including the first visible indications of growth." [GOC:lr]
comment: This term was made obsolete because it is a grouping term without biological significance.
is_obsolete: true

[Term]
id: GO:0009845
name: seed germination
namespace: biological_process
def: "The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis." [PMID:8281041]
xref: Wikipedia:Germination#Seed_germination
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0009846
name: pollen germination
namespace: biological_process
def: "The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture." [GOC:lr, http://www.bio.uu.nl, ISBN:0943088399]
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0009856 ! pollination

[Term]
id: GO:0009847
name: spore germination
namespace: biological_process
def: "The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall)." [GOC:lr]
subset: gosubset_prok
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0009848
name: indoleacetic acid biosynthetic process via tryptophan
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid that occurs through metabolism of L-tryptophan." [GOC:lm, GOC:lr, PMID:10375566]
subset: gosubset_prok
synonym: "IAA biosynthetic process via tryptophan" EXACT []
synonym: "indoleacetic acid anabolism via tryptophan" EXACT []
synonym: "indoleacetic acid formation via tryptophan" EXACT []
synonym: "indoleacetic acid synthesis via tryptophan" EXACT []
xref: MetaCyc:PWY-581
is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0009684 ! indoleacetic acid biosynthetic process

[Term]
id: GO:0009849
name: tryptophan-independent indoleacetic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan." [GOC:go_curators, GOC:lm, GOC:lr, PMID:10375566]
subset: gosubset_prok
synonym: "indoleacetic acid biosynthesis, tryptophan-independent" EXACT []
synonym: "indoleacetic acid biosynthetic process, tryptophan-independent" EXACT []
synonym: "tryptophan-independent IAA biosynthetic process" EXACT []
synonym: "tryptophan-independent indoleacetic acid anabolism" EXACT []
synonym: "tryptophan-independent indoleacetic acid biosynthesis" EXACT []
synonym: "tryptophan-independent indoleacetic acid formation" EXACT []
synonym: "tryptophan-independent indoleacetic acid synthesis" EXACT []
xref: MetaCyc:PWY-581
is_a: GO:0009684 ! indoleacetic acid biosynthetic process

[Term]
id: GO:0009850
name: auxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lr]
subset: gosubset_prok
synonym: "auxin metabolism" EXACT []
is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0009851
name: auxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0122146743]
subset: gosubset_prok
synonym: "auxin anabolism" EXACT []
synonym: "auxin biosynthesis" EXACT []
synonym: "auxin formation" EXACT []
synonym: "auxin synthesis" EXACT []
is_a: GO:0009850 ! auxin metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0009852
name: auxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0198547684]
subset: gosubset_prok
synonym: "auxin breakdown" EXACT []
synonym: "auxin catabolism" EXACT []
synonym: "auxin degradation" EXACT []
is_a: GO:0009850 ! auxin metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0009853
name: photorespiration
namespace: biological_process
def: "A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: MetaCyc:PWY-181
xref: Wikipedia:Photorespiration
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0009854
name: oxidative photosynthetic carbon pathway
namespace: biological_process
def: "The reactions of the C2 pathway bring about the metabolic conversion of two molecules of 2-phosphoglycolate to one molecule of 3-phosphoglycerate, which can be used by the C3 cycle, and one molecule of carbon dioxide (CO2)." [ISBN:00943088399]
subset: gosubset_prok
is_a: GO:0043094 ! cellular metabolic compound salvage
relationship: part_of GO:0009853 ! photorespiration

[Term]
id: GO:0009855
name: determination of bilateral symmetry
namespace: biological_process
def: "The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:go_curators]
is_a: GO:0009799 ! specification of symmetry

[Term]
id: GO:0009856
name: pollination
namespace: biological_process
def: "The cascade of biological processes occurring in plants beginning when the pollen lands on the stigma and continuing up to, but not including, fertilization, as defined by sperm-central cell fusion." [GOC:tb, PMID:10973091]
subset: goslim_plant
xref: Wikipedia:Pollination
is_a: GO:0022414 ! reproductive process
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0009858
name: compatible pollen-pistil interaction
namespace: biological_process
def: "OBSOLETE. An interaction between a pollen grain and pistil that results in unimpeded growth of the pollen tube through the stigma and style." [GOC:lr, ISBN:0387987819]
comment: This term was made obsolete because it represents a phenotype.
is_obsolete: true

[Term]
id: GO:0009859
name: pollen hydration
namespace: biological_process
def: "The process by which water is taken up by pollen." [GOC:lr]
is_a: GO:0006833 ! water transport
relationship: part_of GO:0009875 ! pollen-pistil interaction

[Term]
id: GO:0009860
name: pollen tube growth
namespace: biological_process
def: "Growth of pollen via tip extension of the intine wall." [ISBN:00943088399]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0009932 ! cell tip growth
is_a: GO:0048588 ! developmental cell growth
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0048868 ! pollen tube development

[Term]
id: GO:0009861
name: jasmonic acid and ethylene-dependent systemic resistance
namespace: biological_process
def: "The jasmonic acid and ethylene (ethene) dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:jy, PMID:10234273]
synonym: "jasmonic acid and ethene-dependent systemic resistance" EXACT []
synonym: "jasmonic acid/ethylene-dependent systemic resistance" EXACT []
is_a: GO:0009611 ! response to wounding
is_a: GO:0009814 ! defense response, incompatible interaction

[Term]
id: GO:0009862
name: systemic acquired resistance, salicylic acid mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by salicylic acid involved in systemic acquired resistance." [GOC:jy]
synonym: "salicylic acid mediated signaling pathway (systemic acquired resistance)" EXACT []
synonym: "systemic acquired resistance, salicylic acid mediated signalling pathway" EXACT []
is_a: GO:0009863 ! salicylic acid mediated signaling pathway
relationship: part_of GO:0009627 ! systemic acquired resistance

[Term]
id: GO:0009863
name: salicylic acid mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by salicylic acid." [GOC:jy]
synonym: "salicylic acid mediated signalling pathway" EXACT []
is_a: GO:0007242 ! intracellular signaling cascade
is_a: GO:0071446 ! cellular response to salicylic acid stimulus

[Term]
id: GO:0009864
name: induced systemic resistance, jasmonic acid mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by jasmonic acid involved in induced systemic resistance." [GOC:jy]
synonym: "induced systemic resistance, jasmonic acid mediated signalling pathway" EXACT []
synonym: "jasmonic acid mediated signaling pathway (induced systemic resistance)" EXACT []
is_a: GO:0002218 ! activation of innate immune response
is_a: GO:0009867 ! jasmonic acid mediated signaling pathway
relationship: part_of GO:0009682 ! induced systemic resistance

[Term]
id: GO:0009865
name: pollen tube adhesion
namespace: biological_process
def: "The process by which the pollen tube adheres to cells of the stigma and style." [GOC:tair_curators, PMID:12602877]
is_a: GO:0016337 ! cell-cell adhesion
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0009875 ! pollen-pistil interaction
relationship: part_of GO:0048868 ! pollen tube development

[Term]
id: GO:0009866
name: induced systemic resistance, ethylene mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by ethylene (ethene) involved in induced systemic resistance." [GOC:jy]
synonym: "ethene mediated signaling pathway (induced systemic resistance)" EXACT []
synonym: "ethylene mediated signaling pathway (induced systemic resistance)" EXACT []
synonym: "induced systemic resistance, ethene mediated signaling pathway" EXACT []
synonym: "induced systemic resistance, ethene mediated signalling pathway" EXACT []
synonym: "induced systemic resistance, ethylene mediated signalling pathway" EXACT []
is_a: GO:0002218 ! activation of innate immune response
is_a: GO:0009873 ! ethylene mediated signaling pathway
relationship: part_of GO:0009682 ! induced systemic resistance

[Term]
id: GO:0009867
name: jasmonic acid mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by jasmonic acid." [GOC:jy]
synonym: "jasmonic acid mediated signalling pathway" EXACT []
is_a: GO:0007242 ! intracellular signaling cascade
is_a: GO:0071395 ! cellular response to jasmonic acid stimulus

[Term]
id: GO:0009868
name: jasmonic acid and ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by jasmonic acid involved in jasmonic acid/ethylene (ethene) dependent systemic resistance." [GOC:jy]
synonym: "jasmonic acid and ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT []
synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT []
synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT []
synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT []
synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT []
synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT []
synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT []
is_a: GO:0009867 ! jasmonic acid mediated signaling pathway
is_a: GO:0032260 ! response to jasmonic acid stimulus during jasmonic acid and ethylene-dependent systemic resistance

[Term]
id: GO:0009869
name: incompatible pollen-pistil interaction
namespace: biological_process
def: "OBSOLETE. An interaction between a pollen grain and pistil that results in inhibition of pollen germination/growth." [PMID:10375566]
comment: This term was made obsolete because it represents a phenotype.
is_obsolete: true

[Term]
id: GO:0009870
name: defense response signaling pathway, resistance gene-dependent
namespace: biological_process
def: "A series of molecular signals that depends upon R-genes and is activated during defense response." [GOC:jy, GOC:mah, PMID:11418339]
synonym: "defence response signaling pathway, resistance gene-dependent" EXACT []
synonym: "defence response signalling pathway, resistance gene-dependent" EXACT []
synonym: "defense response signalling pathway, resistance gene-dependent" EXACT []
is_a: GO:0002218 ! activation of innate immune response
is_a: GO:0007242 ! intracellular signaling cascade

[Term]
id: GO:0009871
name: jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by ethylene (ethene) involved in jasmonic acid/ethylene dependent systemic resistance." [GOC:jy]
synonym: "ethene mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT []
synonym: "ethylene mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT []
synonym: "jasmonic acid and ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT []
synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT []
synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signalling pathway" EXACT []
synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signaling pathway" EXACT []
synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signalling pathway" EXACT []
is_a: GO:0009873 ! ethylene mediated signaling pathway
relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance

[Term]
id: GO:0009872
name: gametophytic self-incompatibility
namespace: biological_process
def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819]
comment: This term was made obsolete because it represents a phenotype.
is_obsolete: true

[Term]
id: GO:0009873
name: ethylene mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by ethylene (ethene)." [GOC:jy]
synonym: "ethene mediated signaling pathway" EXACT []
synonym: "ethene mediated signalling pathway" EXACT []
synonym: "ethylene mediated signalling pathway" EXACT []
is_a: GO:0000160 ! two-component signal transduction system (phosphorelay)
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0023034 ! intracellular signaling pathway
is_a: GO:0071369 ! cellular response to ethylene stimulus

[Term]
id: GO:0009874
name: sporophytic self-incompatibility
namespace: biological_process
def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819]
comment: This term was made obsolete because it represents a phenotype.
is_obsolete: true

[Term]
id: GO:0009875
name: pollen-pistil interaction
namespace: biological_process
def: "The interaction between a pollen grain and pistil." [GOC:go_curators]
subset: goslim_plant
is_a: GO:0007154 ! cell communication
relationship: part_of GO:0009856 ! pollination

[Term]
id: GO:0009876
name: pollen adhesion
namespace: biological_process
def: "The process by which pollen deposited on the stigma adheres to cells of the stigma." [GOC:tair_curators]
is_a: GO:0016337 ! cell-cell adhesion
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0009875 ! pollen-pistil interaction

[Term]
id: GO:0009877
name: nodulation
namespace: biological_process
def: "The formation of nitrogen-fixing root nodules on plant roots." [SP_KW:KW-0536]
is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0009878
name: nodule morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the nodule are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0009877 ! nodulation

[Term]
id: GO:0009879
name: determination of radial symmetry
namespace: biological_process
def: "The establishment of an organism's body plan or a part of an organism such that it is symmetric around a central axis." [GOC:go_curators]
is_a: GO:0009799 ! specification of symmetry
relationship: part_of GO:0009956 ! radial pattern formation

[Term]
id: GO:0009880
name: embryonic pattern specification
namespace: biological_process
def: "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125]
synonym: "embryonic pattern biosynthesis" BROAD []
synonym: "embryonic pattern formation" BROAD []
synonym: "ventral/lateral system" RELATED []
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0009790 ! embryonic development

[Term]
id: GO:0009881
name: photoreceptor activity
namespace: molecular_function
def: "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators]
subset: gosubset_prok
synonym: "blue-sensitive opsin" NARROW []
synonym: "green-sensitive opsin" NARROW []
synonym: "long-wave-sensitive opsin" NARROW []
synonym: "opsin" NARROW []
synonym: "red-sensitive opsin" NARROW []
synonym: "short-wave-sensitive opsin" NARROW []
synonym: "UV-sensitive opsin" NARROW []
synonym: "violet-sensitive opsin" NARROW []
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0009882
name: blue light photoreceptor activity
namespace: molecular_function
def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation." [GOC:tb]
subset: gosubset_prok
is_a: GO:0009881 ! photoreceptor activity

[Term]
id: GO:0009883
name: red or far-red light photoreceptor activity
namespace: molecular_function
def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation." [GOC:lr]
synonym: "red/far-red light photoreceptor activity" EXACT []
is_a: GO:0009881 ! photoreceptor activity

[Term]
id: GO:0009884
name: cytokinin receptor activity
namespace: molecular_function
def: "Combining with a cytokinin to initiate a change in cell activity." [GOC:lr]
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0009885
name: transmembrane histidine kinase cytokinin receptor activity
namespace: molecular_function
def: "A transmembrane receptor of cytokinins that produces a molecular signal via phosphotransfer at histidine residues." [GOC:lr]
is_a: GO:0009784 ! transmembrane receptor histidine kinase activity
is_a: GO:0009884 ! cytokinin receptor activity

[Term]
id: GO:0009886
name: post-embryonic morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
synonym: "post-embryonic morphogenesis of an anatomical structure" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0009791 ! post-embryonic development

[Term]
id: GO:0009887
name: organ morphogenesis
namespace: biological_process
def: "Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "histogenesis and organogenesis" BROAD []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048513 ! organ development

[Term]
id: GO:0009888
name: tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208]
synonym: "histogenesis" EXACT []
synonym: "histogenesis and organogenesis" BROAD []
xref: Wikipedia:Histogenesis
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048513 ! organ development

[Term]
id: GO:0009889
name: regulation of biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of anabolism" EXACT []
synonym: "regulation of biosynthesis" EXACT []
synonym: "regulation of formation" EXACT []
synonym: "regulation of synthesis" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0009058 ! biosynthetic process

[Term]
id: GO:0009890
name: negative regulation of biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of biosynthetic process" EXACT []
synonym: "down-regulation of biosynthetic process" EXACT []
synonym: "downregulation of biosynthetic process" EXACT []
synonym: "inhibition of biosynthetic process" NARROW []
synonym: "negative regulation of anabolism" EXACT []
synonym: "negative regulation of biosynthesis" EXACT []
synonym: "negative regulation of formation" EXACT []
synonym: "negative regulation of synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0009892 ! negative regulation of metabolic process
relationship: negatively_regulates GO:0009058 ! biosynthetic process

[Term]
id: GO:0009891
name: positive regulation of biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of biosynthetic process" NARROW []
synonym: "positive regulation of anabolism" EXACT []
synonym: "positive regulation of biosynthesis" EXACT []
synonym: "positive regulation of formation" EXACT []
synonym: "positive regulation of synthesis" EXACT []
synonym: "stimulation of biosynthetic process" NARROW []
synonym: "up regulation of biosynthetic process" EXACT []
synonym: "up-regulation of biosynthetic process" EXACT []
synonym: "upregulation of biosynthetic process" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0009893 ! positive regulation of metabolic process
relationship: positively_regulates GO:0009058 ! biosynthetic process

[Term]
id: GO:0009892
name: negative regulation of metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of metabolic process" EXACT []
synonym: "down-regulation of metabolic process" EXACT []
synonym: "downregulation of metabolic process" EXACT []
synonym: "inhibition of metabolic process" NARROW []
synonym: "negative regulation of metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0008152 ! metabolic process

[Term]
id: GO:0009893
name: positive regulation of metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of metabolic process" NARROW []
synonym: "positive regulation of metabolism" EXACT []
synonym: "stimulation of metabolic process" NARROW []
synonym: "up regulation of metabolic process" EXACT []
synonym: "up-regulation of metabolic process" EXACT []
synonym: "upregulation of metabolic process" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0008152 ! metabolic process

[Term]
id: GO:0009894
name: regulation of catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of breakdown" EXACT []
synonym: "regulation of catabolism" EXACT []
synonym: "regulation of degradation" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0009056 ! catabolic process

[Term]
id: GO:0009895
name: negative regulation of catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of catabolic process" EXACT []
synonym: "down-regulation of catabolic process" EXACT []
synonym: "downregulation of catabolic process" EXACT []
synonym: "inhibition of catabolic process" NARROW []
synonym: "negative regulation of breakdown" EXACT []
synonym: "negative regulation of catabolism" EXACT []
synonym: "negative regulation of degradation" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0009894 ! regulation of catabolic process
relationship: negatively_regulates GO:0009056 ! catabolic process

[Term]
id: GO:0009896
name: positive regulation of catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of catabolic process" NARROW []
synonym: "positive regulation of breakdown" EXACT []
synonym: "positive regulation of catabolism" EXACT []
synonym: "positive regulation of degradation" EXACT []
synonym: "stimulation of catabolic process" NARROW []
synonym: "up regulation of catabolic process" EXACT []
synonym: "up-regulation of catabolic process" EXACT []
synonym: "upregulation of catabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0009894 ! regulation of catabolic process
relationship: positively_regulates GO:0009056 ! catabolic process

[Term]
id: GO:0009897
name: external side of plasma membrane
namespace: cellular_component
def: "The side of the plasma membrane that is opposite to the side that faces the cytoplasm." [GOC:tb]
subset: gosubset_prok
synonym: "juxtamembrane" BROAD []
synonym: "outer surface of cytoplasmic membrane" EXACT []
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0009986 ! cell surface

[Term]
id: GO:0009898
name: internal side of plasma membrane
namespace: cellular_component
def: "The side of the plasma membrane that faces the cytoplasm." [GOC:tb]
subset: gosubset_prok
synonym: "juxtamembrane" BROAD []
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0009899
name: ent-kaurene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-kaurene + diphosphate." [EC:4.2.3.19, ISBN:0943088399]
synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.19]
synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)" EXACT [EC:4.2.3.19]
synonym: "ent-kaurene synthase B activity" NARROW [EC:4.2.3.19]
synonym: "ent-kaurene synthetase B activity" NARROW [EC:4.2.3.19]
xref: EC:4.2.3.19
xref: MetaCyc:4.2.3.19-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0009900
name: dehiscence
namespace: biological_process
def: "The opening of an anther, fruit or other structure, which permits the escape of reproductive bodies contained within it." [ISBN:0879015322]
xref: Wikipedia:Dehiscence_(botany)
is_a: GO:0048609 ! reproductive process in a multicellular organism

[Term]
id: GO:0009901
name: anther dehiscence
namespace: biological_process
def: "The dehiscence of an anther to release the pollen grains contained within it." [GOC:tb]
is_a: GO:0009900 ! dehiscence
relationship: part_of GO:0048653 ! anther development

[Term]
id: GO:0009902
name: chloroplast relocation
namespace: biological_process
def: "The process by which chloroplasts in photosynthetic cells migrate toward illuminated sites to optimize photosynthesis and move away from excessively illuminated areas to protect the photosynthetic machinery." [PMID:11309623]
synonym: "chloroplast movement" EXACT [GOC:tb, PMID:18715957]
is_a: GO:0009658 ! chloroplast organization
is_a: GO:0051667 ! establishment of plastid localization

[Term]
id: GO:0009903
name: chloroplast avoidance movement
namespace: biological_process
def: "The relocation process by which chloroplasts in photosynthetic cells avoid strong light and move away from it in order to preserve the photosynthetic machinery." [GOC:tb, PMID:11978863]
synonym: "high-fluence-rate response" RELATED []
is_a: GO:0009902 ! chloroplast relocation

[Term]
id: GO:0009904
name: chloroplast accumulation movement
namespace: biological_process
def: "The relocation process by which chloroplasts in photosynthetic cells move toward a brighter area in a cell to optimize photosynthesis." [GOC:tb, PMID:11978863]
synonym: "low-fluence-rate response" RELATED []
is_a: GO:0009902 ! chloroplast relocation

[Term]
id: GO:0009905
name: ent-copalyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate = ent-copalyl diphosphate." [EC:5.5.1.13, ISBN:0943088399]
synonym: "diterpene cyclase activity" BROAD []
synonym: "ent-copalyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.13]
synonym: "ent-kaurene synthase A activity" NARROW [EC:5.5.1.13]
synonym: "ent-kaurene synthetase A activity" NARROW [EC:5.5.1.13]
xref: EC:5.5.1.13
xref: MetaCyc:5.5.1.13-RXN
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0009906
name: response to photoperiod, blue light
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a blue light photoperiod stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:go_curators, GOC:mtg_far_red]
is_a: GO:0009637 ! response to blue light
is_a: GO:0009648 ! photoperiodism

[Term]
id: GO:0009907
name: response to photoperiod, red light
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light photoperiod stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm." [GOC:go_curators, GOC:mtg_far_red]
is_a: GO:0009648 ! photoperiodism
is_a: GO:0010114 ! response to red light

[Term]
id: GO:0009908
name: flower development
namespace: biological_process
alt_id: GO:0048409
def: "The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem." [GOC:tb, ISBN:0879015322]
subset: goslim_plant
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0009909
name: regulation of flower development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of flower development." [GOC:go_curators]
is_a: GO:0048580 ! regulation of post-embryonic development
relationship: regulates GO:0009908 ! flower development

[Term]
id: GO:0009910
name: negative regulation of flower development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of flower development." [GOC:go_curators]
synonym: "down regulation of flower development" EXACT []
synonym: "down-regulation of flower development" EXACT []
synonym: "downregulation of flower development" EXACT []
synonym: "inhibition of flower development" NARROW []
is_a: GO:0009909 ! regulation of flower development
is_a: GO:0048581 ! negative regulation of post-embryonic development
relationship: negatively_regulates GO:0009908 ! flower development

[Term]
id: GO:0009911
name: positive regulation of flower development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of flower development." [GOC:go_curators]
synonym: "activation of flower development" NARROW []
synonym: "stimulation of flower development" NARROW []
synonym: "up regulation of flower development" EXACT []
synonym: "up-regulation of flower development" EXACT []
synonym: "upregulation of flower development" EXACT []
is_a: GO:0009909 ! regulation of flower development
is_a: GO:0048582 ! positive regulation of post-embryonic development
relationship: positively_regulates GO:0009908 ! flower development

[Term]
id: GO:0009912
name: auditory receptor cell fate commitment
namespace: biological_process
def: "The process by which the cellular identity of auditory hair cells is acquired and determined." [GOC:lr]
synonym: "auditory hair cell fate commitment" EXACT []
is_a: GO:0060120 ! inner ear receptor cell fate commitment
relationship: part_of GO:0042491 ! auditory receptor cell differentiation

[Term]
id: GO:0009913
name: epidermal cell differentiation
namespace: biological_process
alt_id: GO:0043355
def: "The process whereby a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb]
synonym: "hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0008544 ! epidermis development

[Term]
id: GO:0009914
name: hormone transport
namespace: biological_process
def: "The directed movement of hormones into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:tb]
subset: goslim_pir
is_a: GO:0006810 ! transport
is_a: GO:0010817 ! regulation of hormone levels

[Term]
id: GO:0009915
name: phloem loading
namespace: biological_process
def: "The process of loading sucrose into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:sm]
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0009916
name: alternative oxidase activity
namespace: molecular_function
def: "Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product." [ISBN:0943088399]
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0009917
name: sterol 5-alpha reductase activity
namespace: molecular_function
def: "Catalysis of the removal of a C-5 double bond in the B ring of a sterol." [ISBN:0943088399]
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0009918
name: sterol delta7 reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol." [ISBN:0943088399]
synonym: "sterol delta-7 reductase activity" EXACT []
xref: MetaCyc:RXN-707
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0009919
name: cytokinesis (sensu Viridiplantae)
namespace: biological_process
def: "OBSOLETE. The division of a cell into two daughter cells with cell walls." [GOC:tb]
comment: This term was made obsolete because its meaning was changed significantly.
is_obsolete: true
consider: GO:0000911

[Term]
id: GO:0009920
name: cell plate formation involved in plant-type cell wall biogenesis
namespace: biological_process
def: "The cell cycle process whereby the cell plate is formed at the equator of the spindle in the dividing cells during early telophase. An example of this is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb, ISBN:0879015322]
synonym: "cell plate formation involved in cellulose and pectin-containing cell wall biogenesis" EXACT []
is_a: GO:0000919 ! cell plate assembly
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007067 ! mitosis
relationship: part_of GO:0009832 ! plant-type cell wall biogenesis

[Term]
id: GO:0009921
name: auxin efflux carrier complex
namespace: cellular_component
def: "The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell." [PMID:9843496]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0009922
name: fatty acid elongase activity
namespace: molecular_function
def: "Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb]
xref: MetaCyc:ICOSANOYL-COA-SYNTHASE-RXN
is_a: GO:0004312 ! fatty-acid synthase activity

[Term]
id: GO:0009923
name: fatty acid elongase complex
namespace: cellular_component
def: "A tetrameric complex of four different subunits which catalyzes the elongation of fatty acids chains 2 carbon units at a time in the synthesis of very long chain fatty acids." [GOC:tb]
is_a: GO:0031373 ! cytosolic fatty acid synthase complex

[Term]
id: GO:0009924
name: octadecanal decarbonylase activity
namespace: molecular_function
def: "Catalysis of the reaction: octadecanal = heptadecane + CO." [EC:4.1.99.5, GOC:tb]
synonym: "aldehyde decarbonylase activity" EXACT []
synonym: "decarbonylase activity" EXACT [EC:4.1.99.5]
synonym: "octadecanal alkane-lyase activity" EXACT []
xref: EC:4.1.99.5
xref: MetaCyc:OCTADECANAL-DECARBONYLASE-RXN
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0009925
name: basal plasma membrane
namespace: cellular_component
def: "The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0016323 ! basolateral plasma membrane
relationship: part_of GO:0045178 ! basal part of cell

[Term]
id: GO:0009926
name: auxin polar transport
namespace: biological_process
def: "The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally." [GOC:sm]
is_a: GO:0060918 ! auxin transport

[Term]
id: GO:0009927
name: histidine phosphotransfer kinase activity
namespace: molecular_function
def: "Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator." [PMID:11842140]
subset: gosubset_prok
is_a: GO:0004871 ! signal transducer activity
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0009930
name: longitudinal side of cell surface
namespace: cellular_component
def: "The side of the cell parallel to the zygotic axis." [GOC:mtg_sensu, GOC:sm]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0009986 ! cell surface

[Term]
id: GO:0009931
name: calcium-dependent protein serine/threonine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of calcium ions." [GOC:mah]
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0010857 ! calcium-dependent protein kinase activity

[Term]
id: GO:0009932
name: cell tip growth
namespace: biological_process
def: "Growth that occurs specifically at the tip of a cell." [GOC:jic]
is_a: GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0009933
name: meristem structural organization
namespace: biological_process
def: "Organization of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm, ISBN:0198547684]
synonym: "meristem organisation" BROAD []
synonym: "meristem organization" BROAD []
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0048507 ! meristem development

[Term]
id: GO:0009934
name: regulation of meristem structural organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meristem organization." [GOC:jic]
synonym: "regulation of meristem organisation" EXACT []
synonym: "regulation of meristem organization" BROAD [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0048509 ! regulation of meristem development
relationship: regulates GO:0009933 ! meristem structural organization

[Term]
id: GO:0009935
name: nutrient import
namespace: biological_process
def: "OBSOLETE. The directed movement of nutrients into a cell or organelle." [GOC:sm]
comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning.
subset: gosubset_prok
synonym: "nutrient uptake" EXACT []
is_obsolete: true
consider: GO:0006810

[Term]
id: GO:0009936
name: expansin
namespace: molecular_function
def: "OBSOLETE. A group of proteins located within the cell walls of plants, both dicots and grasses, that play an essential role in loosening cell walls during cell growth. They are hydrophobic, non glycosylated proteins of about 30kDa." [ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0009505
replaced_by: GO:0016049

[Term]
id: GO:0009937
name: regulation of gibberellic acid mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gibberellic acid mediated signaling." [GOC:go_curators]
synonym: "regulation of gibberellic acid mediated signalling" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0009740 ! gibberellic acid mediated signaling pathway

[Term]
id: GO:0009938
name: negative regulation of gibberellic acid mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm]
synonym: "down regulation of gibberellic acid mediated signaling" EXACT []
synonym: "down-regulation of gibberellic acid mediated signaling" EXACT []
synonym: "downregulation of gibberellic acid mediated signaling" EXACT []
synonym: "inhibition of gibberellic acid mediated signaling" NARROW []
synonym: "negative regulation of gibberellic acid mediated signalling" EXACT []
is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway

[Term]
id: GO:0009939
name: positive regulation of gibberellic acid mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm]
synonym: "activation of gibberellic acid mediated signaling" NARROW []
synonym: "positive regulation of gibberellic acid mediated signalling" EXACT []
synonym: "stimulation of gibberellic acid mediated signaling" NARROW []
synonym: "up regulation of gibberellic acid mediated signaling" EXACT []
synonym: "up-regulation of gibberellic acid mediated signaling" EXACT []
synonym: "upregulation of gibberellic acid mediated signaling" EXACT []
is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway

[Term]
id: GO:0009940
name: amino-terminal vacuolar sorting propeptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin coated vesicles." [GOC:sm, PMID:10871276]
is_a: GO:0010209 ! vacuolar sorting signal binding

[Term]
id: GO:0009941
name: chloroplast envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb]
is_a: GO:0009526 ! plastid envelope
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0009942
name: longitudinal axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the longitudinal axis. In plants, this is the axis that runs from the shoot to the root." [GOC:tb]
synonym: "apical-basal pattern specification" EXACT []
synonym: "longitudinal axis determination" RELATED [GOC:dph]
is_a: GO:0000578 ! embryonic axis specification
is_a: GO:0003006 ! reproductive developmental process
relationship: part_of GO:0009793 ! embryonic development ending in seed dormancy

[Term]
id: GO:0009943
name: adaxial/abaxial axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the adaxial / abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb]
synonym: "adaxial/abaxial determination" RELATED [GOC:dph]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009955 ! adaxial/abaxial pattern formation

[Term]
id: GO:0009944
name: polarity specification of adaxial/abaxial axis
namespace: biological_process
def: "The process resulting in the establishment of polarity along the adaxial/abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb]
is_a: GO:0065001 ! specification of axis polarity
relationship: part_of GO:0009943 ! adaxial/abaxial axis specification

[Term]
id: GO:0009945
name: radial axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of an axis that initiates at a point and radiates outward from the point." [GOC:dph, GOC:go_curators, GOC:isa_complete]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009956 ! radial pattern formation

[Term]
id: GO:0009946
name: proximal/distal axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "proximal/distal axis determination" RELATED [GOC:dph]
synonym: "proximodistal axis specification" EXACT []
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009954 ! proximal/distal pattern formation

[Term]
id: GO:0009947
name: centrolateral axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the centrolateral axis. In plants, this axis is duplicated and runs from the midrib to the margin of the leaf." [GOC:tb, ISBN:0865427429]
synonym: "centrolateral axis determination" RELATED [GOC:dph]
is_a: GO:0009798 ! axis specification

[Term]
id: GO:0009948
name: anterior/posterior axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "anterior/posterior axis determination" RELATED [GOC:dph]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009952 ! anterior/posterior pattern formation

[Term]
id: GO:0009949
name: polarity specification of anterior/posterior axis
namespace: biological_process
def: "Any process resulting in the establishment of polarity along the anterior/posterior axis." [GOC:go_curators]
is_a: GO:0065001 ! specification of axis polarity
relationship: part_of GO:0009948 ! anterior/posterior axis specification

[Term]
id: GO:0009950
name: dorsal/ventral axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "dorsal-ventral axis specification" EXACT [GOC:mah]
synonym: "dorsal/ventral axis determination" RELATED [GOC:dph]
synonym: "dorsoventral axis specification" EXACT [GOC:mah]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009953 ! dorsal/ventral pattern formation

[Term]
id: GO:0009951
name: polarity specification of dorsal/ventral axis
namespace: biological_process
def: "Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators]
synonym: "polarity specification of dorsal-ventral axis" EXACT [GOC:mah]
synonym: "polarity specification of dorsoventral axis" EXACT [GOC:mah]
is_a: GO:0065001 ! specification of axis polarity
relationship: part_of GO:0009950 ! dorsal/ventral axis specification

[Term]
id: GO:0009952
name: anterior/posterior pattern formation
namespace: biological_process
def: "The regionalization process by which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
synonym: "anterior/posterior pattern specification" NARROW []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009953
name: dorsal/ventral pattern formation
namespace: biological_process
def: "The regionalization process by which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb]
synonym: "dorsal-ventral pattern formation" EXACT [GOC:mah]
synonym: "dorsal/ventral pattern specification" NARROW []
synonym: "dorsoventral pattern formation" EXACT [GOC:mah]
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009954
name: proximal/distal pattern formation
namespace: biological_process
def: "The regionalization process by which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:isa_complete]
synonym: "proximal/distal pattern specification" NARROW []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009955
name: adaxial/abaxial pattern formation
namespace: biological_process
def: "The regionalization process by which differences in cell differentiation along the adaxial/abaxial are generated. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:isa_complete, GOC:tb]
synonym: "adaxial/abaxial pattern specification" NARROW []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009956
name: radial pattern formation
namespace: biological_process
def: "The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur." [GOC:dph, GOC:go_curators, GOC:isa_complete]
synonym: "radial pattern specification" NARROW []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0009957
name: epidermal cell fate specification
namespace: biological_process
alt_id: GO:0043356
def: "The process by which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu, GOC:sm]
synonym: "hypodermal cell fate specification" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0009913 ! epidermal cell differentiation

[Term]
id: GO:0009958
name: positive gravitropism
namespace: biological_process
def: "The orientation of plant parts towards gravity." [GOC:sm]
synonym: "root gravitropism" NARROW []
is_a: GO:0009630 ! gravitropism

[Term]
id: GO:0009959
name: negative gravitropism
namespace: biological_process
def: "The orientation of plant parts away from gravity." [GOC:sm]
synonym: "shoot gravitropism" NARROW []
is_a: GO:0009630 ! gravitropism

[Term]
id: GO:0009960
name: endosperm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endosperm over time, from its formation to the mature structure. The endosperm is formed during fertilization and provides nutrients to the developing embryo." [GOC:sm]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0009961
name: response to 1-aminocyclopropane-1-carboxylic acid
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus." [GOC:jl]
is_a: GO:0009725 ! response to hormone stimulus

[Term]
id: GO:0009962
name: regulation of flavonoid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb]
subset: gosubset_prok
synonym: "regulation of flavonoid anabolism" EXACT []
synonym: "regulation of flavonoid biosynthesis" EXACT []
synonym: "regulation of flavonoid formation" EXACT []
synonym: "regulation of flavonoid synthesis" EXACT []
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043455 ! regulation of secondary metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0009813 ! flavonoid biosynthetic process

[Term]
id: GO:0009963
name: positive regulation of flavonoid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb]
subset: gosubset_prok
synonym: "activation of flavonoid biosynthetic process" NARROW []
synonym: "positive regulation of flavonoid anabolism" EXACT []
synonym: "positive regulation of flavonoid biosynthesis" EXACT []
synonym: "positive regulation of flavonoid formation" EXACT []
synonym: "positive regulation of flavonoid synthesis" EXACT []
synonym: "stimulation of flavonoid biosynthetic process" NARROW []
synonym: "up regulation of flavonoid biosynthetic process" EXACT []
synonym: "up-regulation of flavonoid biosynthetic process" EXACT []
synonym: "upregulation of flavonoid biosynthetic process" EXACT []
is_a: GO:0009962 ! regulation of flavonoid biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
relationship: positively_regulates GO:0009813 ! flavonoid biosynthetic process

[Term]
id: GO:0009964
name: negative regulation of flavonoid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb]
subset: gosubset_prok
synonym: "down regulation of flavonoid biosynthetic process" EXACT []
synonym: "down-regulation of flavonoid biosynthetic process" EXACT []
synonym: "downregulation of flavonoid biosynthetic process" EXACT []
synonym: "inhibition of flavonoid biosynthetic process" NARROW []
synonym: "negative regulation of flavonoid anabolism" EXACT []
synonym: "negative regulation of flavonoid biosynthesis" EXACT []
synonym: "negative regulation of flavonoid formation" EXACT []
synonym: "negative regulation of flavonoid synthesis" EXACT []
is_a: GO:0009962 ! regulation of flavonoid biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
relationship: negatively_regulates GO:0009813 ! flavonoid biosynthetic process

[Term]
id: GO:0009965
name: leaf morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the leaf are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0010016 ! shoot morphogenesis
relationship: part_of GO:0048366 ! leaf development

[Term]
id: GO:0009966
name: regulation of signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm]
subset: gosubset_prok
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0023051 ! regulation of signaling process
relationship: regulates GO:0007165 ! signal transduction

[Term]
id: GO:0009967
name: positive regulation of signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm]
subset: gosubset_prok
synonym: "activation of signal transduction" NARROW []
synonym: "stimulation of signal transduction" NARROW []
synonym: "up regulation of signal transduction" EXACT []
synonym: "up-regulation of signal transduction" EXACT []
synonym: "upregulation of signal transduction" EXACT []
xref: Reactome:110518 "Activated DTOR also phosphorylates D4EBP"
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0023056 ! positive regulation of signaling process
relationship: positively_regulates GO:0007165 ! signal transduction

[Term]
id: GO:0009968
name: negative regulation of signal transduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction." [GOC:sm]
subset: gosubset_prok
synonym: "down regulation of signal transduction" EXACT []
synonym: "down-regulation of signal transduction" EXACT []
synonym: "downregulation of signal transduction" EXACT []
synonym: "inhibition of signal transduction" NARROW []
xref: Reactome:110485 "DTSC1 AND DTSC2 form a complex"
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0023057 ! negative regulation of signaling process
relationship: negatively_regulates GO:0007165 ! signal transduction

[Term]
id: GO:0009969
name: xyloglucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xyloglucan, the cross-linking glycan composed of 1->4-beta-D glucan backbone substituted at regular intervals with beta-D-xylosyl-1->6 residues, which is present in the primary cell wall of most higher plants." [GOC:sm]
subset: gosubset_prok
synonym: "xyloglucan anabolism" EXACT []
synonym: "xyloglucan biosynthesis" EXACT []
synonym: "xyloglucan formation" EXACT []
synonym: "xyloglucan synthesis" EXACT []
is_a: GO:0009250 ! glucan biosynthetic process

[Term]
id: GO:0009970
name: cellular response to sulfate starvation
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate." [GOC:sm]
synonym: "cellular response to sulphate starvation" EXACT []
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0009971
name: anastral spindle assembly involved in male meiosis
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the anastral spindle in male meiotic cells." [GOC:tb, PMID:11973272]
is_a: GO:0007053 ! spindle assembly involved in male meiosis
is_a: GO:0055048 ! anastral spindle assembly

[Term]
id: GO:0009972
name: cytidine deamination
namespace: biological_process
def: "The removal of amino group in the presence of water." [GOC:sm]
subset: gosubset_prok
is_a: GO:0006216 ! cytidine catabolic process

[Term]
id: GO:0009973
name: adenylyl-sulfate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + SO3(2-) (sulfite) + acceptor = adenylyl sulfate + reduced acceptor." [EC:1.8.99.2, PMID:5421934]
subset: gosubset_prok
synonym: "adenosine 5'-phosphosulfate reductase" EXACT [EC:1.8.99.2]
synonym: "adenosine phosphosulfate reductase activity" EXACT [EC:1.8.99.2]
synonym: "adenylyl-sulphate reductase activity" EXACT [EC:1.8.99.2]
synonym: "AMP, sulfite:(acceptor) oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.99.2]
synonym: "AMP, sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.99.2]
synonym: "APS reductase activity" EXACT [EC:1.8.99.2]
synonym: "APS-reductase" EXACT [EC:1.8.99.2]
xref: EC:1.8.99.2
xref: MetaCyc:ADENYLYLSULFATE-REDUCTASE-RXN
is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors

[Term]
id: GO:0009974
name: epsilon hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of zeinoxanthin to lutein. Adds hydroxy group to the epsilon ring of the alpha-carotene." [PMID:8837513]
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0009975
name: cyclase activity
namespace: molecular_function
def: "Catalysis of a ring closure reaction." [ISBN:0198547684]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0009976
name: tocopherol cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol)." [PMID:12213958]
is_a: GO:0009975 ! cyclase activity

[Term]
id: GO:0009977
name: proton motive force dependent protein transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of proteins from one side of the membrane to the other. Transportation is dependent on pH gradient across the membrane." [PMID:11526245]
synonym: "delta-pH-dependent protein transporter activity" EXACT []
synonym: "pH-dependent protein transporter activity" EXACT []
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity

[Term]
id: GO:0009978
name: allene oxide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O." [EC:4.2.1.92, MetaCyc:RXN1F-19, PMID:9778849]
synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]" RELATED [EC:4.2.1.92]
synonym: "HPI" RELATED [EC:4.2.1.92]
synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92]
synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92]
xref: MetaCyc:RXN1F-19
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0009979
name: 16:0 monogalactosyldiacylglycerol desaturase activity
namespace: molecular_function
def: "Catalysis of the introduction of an omega-3 double bond into an unsaturated 16-carbon fatty acid in a monogalactosyldiacylglycerol molecule." [GOC:mah, MetaCyc:RXN-1728, MetaCyc:RXN-8304, MetaCyc:RXN-8307]
is_a: GO:0042389 ! omega-3 fatty acid desaturase activity

[Term]
id: GO:0009980
name: glutamate carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups." [EC:3.4.17.11, MetaCyc:3.4.17.11-RXN]
comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined.
subset: gosubset_prok
synonym: "carboxypeptidase G activity" BROAD [EC:3.4.17.11]
synonym: "carboxypeptidase G1 activity" RELATED [EC:3.4.17.11]
synonym: "carboxypeptidase G2 activity" RELATED [EC:3.4.17.11]
synonym: "glutamyl carboxypeptidase activity" EXACT [EC:3.4.17.11]
synonym: "N-pteroyl-L-glutamate hydrolase activity" EXACT [EC:3.4.17.11]
xref: EC:3.4.17.11
xref: MetaCyc:3.4.17.11-RXN
is_obsolete: true
replaced_by: GO:0004180

[Term]
id: GO:0009982
name: pseudouridine synthase activity
namespace: molecular_function
alt_id: GO:0016439
def: "Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah]
comment: Note that this term should not be confused with 'pseudouridylate synthase activity ; GO:0004730', which refers to the formation of free pseudouridine from uracil and ribose-5-phosphate.
subset: gosubset_prok
synonym: "transfer ribonucleate pseudouridine synthetase activity" NARROW [EC:5.4.99.12]
synonym: "transfer RNA pseudouridine synthetase activity" NARROW [EC:5.4.99.12]
synonym: "tRNA pseudouridylate synthase I activity" NARROW [EC:5.4.99.12]
synonym: "tRNA-pseudouridine synthase activity" NARROW []
synonym: "tRNA-pseudouridine synthase I activity" NARROW []
synonym: "tRNA-uridine isomerase activity" NARROW [EC:5.4.99.12]
synonym: "tRNA-uridine uracilmutase activity" NARROW [EC:5.4.99.12]
xref: EC:5.4.99.12
xref: MetaCyc:TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0009983
name: tyrosine aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of N-terminal tyrosine from a peptide." [GOC:sm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined.
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0009984
name: adenylate forming enzyme activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: substrate + ATP = substrate-AMP + diphosphate." [PMID:12084835]
comment: This term was made obsolete because it does not refer to a specific reaction but rather to a process which results in the formation of AMP.
is_obsolete: true
consider: GO:0046033

[Term]
id: GO:0009985
name: dihydroflavonol(thiole) lyase activity
namespace: molecular_function
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0009986
name: cell surface
namespace: cellular_component
alt_id: GO:0009928
alt_id: GO:0009929
def: "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm]
comment: Note that this term is intended to annotate gene products that are attached (integrated or loosely bound) to the plasma membrane or cell wall.
subset: goslim_goa
subset: goslim_pir
subset: gosubset_prok
synonym: "cell associated" EXACT []
synonym: "cell bound" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0009987
name: cellular process
namespace: biological_process
alt_id: GO:0008151
alt_id: GO:0050875
def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete]
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cell growth and/or maintenance" NARROW []
synonym: "cell physiology" EXACT []
synonym: "cellular physiological process" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0009988
name: cell-cell recognition
namespace: biological_process
def: "Cell recognition between cells, usually involving the formation of specialized cell junctions." [ISBN:0824072820]
is_a: GO:0008037 ! cell recognition

[Term]
id: GO:0009989
name: cell-matrix recognition
namespace: biological_process
def: "Cell recognition that involves the interaction of the cell with the extracellular matrix." [ISBN:0824072820]
is_a: GO:0008037 ! cell recognition

[Term]
id: GO:0009990
name: contact guidance
namespace: biological_process
def: "Cell recognition involving the deposition of specific pathways in the extracellular matrix that guide migrating cells." [ISBN:0824072820]
is_a: GO:0009989 ! cell-matrix recognition

[Term]
id: GO:0009991
name: response to extracellular stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:go_curators]
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0009605 ! response to external stimulus

[Term]
id: GO:0009992
name: cellular water homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of water within a cell." [GOC:dph, GOC:tb]
synonym: "cellular osmoregulation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0006884 ! cell volume homeostasis
is_a: GO:0030104 ! water homeostasis
is_a: GO:0055082 ! cellular chemical homeostasis

[Term]
id: GO:0009994
name: oocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu]
synonym: "oocyte cell differentiation" EXACT []
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0030154 ! cell differentiation
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0009995
name: soluble molecule recognition
namespace: biological_process
def: "The recognition of soluble molecules in the environment." [GOC:go_curators]
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0009996
name: negative regulation of cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from adopting a specific cell fate." [GOC:go_curators]
synonym: "down regulation of cell fate specification" EXACT []
synonym: "down-regulation of cell fate specification" EXACT []
synonym: "downregulation of cell fate specification" EXACT []
synonym: "inhibition of cell fate specification" NARROW []
synonym: "suppression of cell fate" EXACT []
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0042659 ! regulation of cell fate specification
relationship: negatively_regulates GO:0001708 ! cell fate specification

[Term]
id: GO:0009997
name: negative regulation of cardioblast cell fate specification
namespace: biological_process
alt_id: GO:0042687
def: "Any process that restricts, stops or prevents a cell from specifying into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
synonym: "down regulation of cardioblast cell fate specification" EXACT []
synonym: "down-regulation of cardioblast cell fate specification" EXACT []
synonym: "downregulation of cardioblast cell fate specification" EXACT []
synonym: "inhibition of cardioblast cell fate specification" NARROW []
synonym: "suppression of cardioblast cell fate" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042686 ! regulation of cardioblast cell fate specification
relationship: negatively_regulates GO:0042685 ! cardioblast cell fate specification

[Term]
id: GO:0009998
name: negative regulation of retinal cone cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from specifying into a retinal cone cell." [GOC:go_curators]
synonym: "down regulation of retinal cone cell fate specification" EXACT []
synonym: "down-regulation of retinal cone cell fate specification" EXACT []
synonym: "downregulation of retinal cone cell fate specification" EXACT []
synonym: "inhibition of retinal cone cell fate specification" NARROW []
synonym: "negative regulation of retina cone cell fate specification" EXACT []
synonym: "suppression of retina cone cell fate" EXACT []
synonym: "suppression of retinal cone cell fate" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042673 ! regulation of retinal cone cell fate specification
relationship: negatively_regulates GO:0042672 ! retinal cone cell fate specification

[Term]
id: GO:0009999
name: negative regulation of auditory receptor cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from specifying into an auditory hair cell." [GOC:go_curators]
synonym: "down regulation of auditory receptor cell fate specification" EXACT []
synonym: "down-regulation of auditory receptor cell fate specification" EXACT []
synonym: "downregulation of auditory receptor cell fate specification" EXACT []
synonym: "inhibition of auditory receptor cell fate specification" NARROW []
synonym: "negative regulation of auditory hair cell fate specification" EXACT []
synonym: "suppression of auditory receptor cell fate" EXACT []
synonym: "suppression of hair cell fate" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042669 ! regulation of auditory receptor cell fate specification
relationship: negatively_regulates GO:0042667 ! auditory receptor cell fate specification

[Term]
id: GO:0010001
name: glial cell differentiation
namespace: biological_process
alt_id: GO:0007404
alt_id: GO:0043360
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu]
synonym: "glia cell differentiation" EXACT []
synonym: "neuroglia differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0042063 ! gliogenesis

[Term]
id: GO:0010002
name: cardioblast differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
synonym: "cardiac precursor cell differentiation" EXACT [GOC:mtg_heart]
synonym: "cardioblast cell differentiation" EXACT []
synonym: "cardiomyocyte generation" RELATED []
is_a: GO:0035051 ! cardiac cell differentiation

[Term]
id: GO:0010004
name: gastrulation involving germ band extension
namespace: biological_process
def: "A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001703 ! gastrulation with mouth forming first

[Term]
id: GO:0010005
name: cortical microtubule, transverse to long axis
namespace: cellular_component
def: "Arrays of microtubules underlying and connected to the plasma membrane, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell (and root in plants). In plants it influences the direction of cellulose microfibril deposition." [ISBN:0943088399]
is_a: GO:0055028 ! cortical microtubule

[Term]
id: GO:0010006
name: Toc complex
namespace: cellular_component
def: "Protein translocon complex at the chloroplast outer membrane." [PMID:10646606]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009707 ! chloroplast outer membrane

[Term]
id: GO:0010007
name: magnesium chelatase complex
namespace: cellular_component
def: "A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner." [PMID:11842180]
is_a: GO:0043234 ! protein complex
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0010008
name: endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an endosome." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044440 ! endosomal part

[Term]
id: GO:0010009
name: external side of endosome membrane
namespace: cellular_component
def: "The external (cytoplasmic face) of an endosome membrane." [GOC:lr]
is_a: GO:0044425 ! membrane part
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0010011
name: auxin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with auxin, plant hormones that regulate aspects of plant growth." [GOC:sm]
synonym: "auxin receptor" NARROW []
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0010012
name: steroid 22-alpha hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O." [GOC:tb]
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0010013
name: N-1-naphthylphthalamic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with N-1-naphthylphthalamic acid, an auxin transport inhibitor." [GOC:sm]
is_a: GO:0008144 ! drug binding

[Term]
id: GO:0010014
name: meristem initiation
namespace: biological_process
def: "Initiation of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm]
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0009933 ! meristem structural organization

[Term]
id: GO:0010015
name: root morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of roots are generated and organized. Morphogenesis pertains to the creation of form. The root is the usually underground part of a seed plant body that originates from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support." [GOC:sm, ISBN:0877797099]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048364 ! root development

[Term]
id: GO:0010016
name: shoot morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the shoot are generated and organized. Morphogenesis pertains to the creation of form. The shoot is the part of a seed plant body that is usually above ground." [GOC:sm, ISBN:0877797099]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048367 ! shoot development

[Term]
id: GO:0010017
name: red or far-red light signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm]
synonym: "phytochrome signaling pathway" BROAD []
synonym: "red or far red light signalling pathway" EXACT []
synonym: "red or far-red light signaling pathway" EXACT [GOC:tb]
synonym: "red/far red light signaling pathway" EXACT []
is_a: GO:0007242 ! intracellular signaling cascade
is_a: GO:0071489 ! cellular response to red or far red light

[Term]
id: GO:0010018
name: far-red light signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm]
synonym: "far red light signalling pathway" EXACT []
synonym: "far red signaling pathway" EXACT [GOC:tb]
is_a: GO:0010017 ! red or far-red light signaling pathway
is_a: GO:0071490 ! cellular response to far red light

[Term]
id: GO:0010019
name: chloroplast-nucleus signaling pathway
namespace: biological_process
def: "The process by which a molecular signal is transduced between the chloroplast and nucleus, such that expression of nuclear encoding photosynthetic proteins is coupled with chloroplast biogenesis." [PMID:8972595]
synonym: "chloroplast-nucleus signalling pathway" EXACT []
is_a: GO:0007242 ! intracellular signaling cascade

[Term]
id: GO:0010020
name: chloroplast fission
namespace: biological_process
def: "The division of a chloroplast within a cell to form two or more separate chloroplast compartments. This division occurs independently of mitosis." [GOC:lr]
synonym: "chloroplast division" EXACT []
is_a: GO:0009658 ! chloroplast organization
is_a: GO:0043572 ! plastid fission

[Term]
id: GO:0010021
name: amylopectin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amylopectin, the (1,4) linked alpha glucose units with alpha-(1,6) linkages." [ISBN:0943088399]
subset: gosubset_prok
synonym: "amylopectin anabolism" EXACT []
synonym: "amylopectin biosynthesis" EXACT []
synonym: "amylopectin formation" EXACT []
synonym: "amylopectin synthesis" EXACT []
is_a: GO:0009250 ! glucan biosynthetic process
relationship: part_of GO:0019252 ! starch biosynthetic process

[Term]
id: GO:0010022
name: meristem determinacy
namespace: biological_process
def: "The process by which a meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [GOC:lr]
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0010073 ! meristem maintenance

[Term]
id: GO:0010023
name: proanthocyanidin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of proanthocyanidin." [GOC:lm]
subset: gosubset_prok
synonym: "proanthocyanidin anabolism" EXACT []
synonym: "proanthocyanidin biosynthesis" EXACT []
synonym: "proanthocyanidin formation" EXACT []
synonym: "proanthocyanidin synthesis" EXACT []
xref: MetaCyc:PWY-641
is_a: GO:0009813 ! flavonoid biosynthetic process

[Term]
id: GO:0010024
name: phytochromobilin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytochromobilin, which involves the oxidative cleavage of heme by a heme oxygenase(HO) to form biliverdin IX alpha." [PMID:11402195]
subset: gosubset_prok
synonym: "phytochromobilin anabolism" EXACT []
synonym: "phytochromobilin biosynthesis" EXACT []
synonym: "phytochromobilin formation" EXACT []
synonym: "phytochromobilin synthesis" EXACT []
is_a: GO:0033014 ! tetrapyrrole biosynthetic process
is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:0051202 ! phytochromobilin metabolic process

[Term]
id: GO:0010025
name: wax biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids." [ISBN:0943088399]
subset: gosubset_prok
synonym: "wax anabolism" EXACT []
synonym: "wax biosynthesis" EXACT []
synonym: "wax formation" EXACT []
synonym: "wax synthesis" EXACT []
xref: MetaCyc:PWY-282
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0010166 ! wax metabolic process

[Term]
id: GO:0010026
name: trichome differentiation
namespace: biological_process
alt_id: GO:0048271
def: "The process whereby a relatively unspecialized epidermal cell acquires the specialized features of a trichome cell. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, PMID:9367433]
synonym: "trichome cell differentiation" EXACT []
is_a: GO:0035315 ! hair cell differentiation
relationship: part_of GO:0009965 ! leaf morphogenesis

[Term]
id: GO:0010027
name: thylakoid membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the thylakoid membrane." [GOC:dph, GOC:jl, GOC:mah, GOC:tb]
comment: See also the cellular component term 'thylakoid membrane ; GO:0042651'.
synonym: "thylakoid membrane organisation" EXACT [GOC:curators]
synonym: "thylakoid membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009668 ! plastid membrane organization

[Term]
id: GO:0010028
name: xanthophyll cycle
namespace: biological_process
def: "A cyclic series of interconversions involving three xanthophylls, violoxanthin, antheraxanthin, and zeaxanthin. The xanthophyll cycle is involved in regulating energy dissipation in light harvesting complex II." [ISBN:0122146743]
subset: gosubset_prok
xref: MetaCyc:PWY-1141
xref: Wikipedia:Xanthophyll#Xanthophyll_cycle
is_a: GO:0016122 ! xanthophyll metabolic process

[Term]
id: GO:0010029
name: regulation of seed germination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of seed germination." [GOC:sm]
is_a: GO:0048580 ! regulation of post-embryonic development
relationship: regulates GO:0009845 ! seed germination

[Term]
id: GO:0010030
name: positive regulation of seed germination
namespace: biological_process
def: "Any process that activates or increase the rate of seed germination." [GOC:sm]
synonym: "activation of seed germination" NARROW []
synonym: "stimulation of seed germination" NARROW []
synonym: "up regulation of seed germination" EXACT []
synonym: "up-regulation of seed germination" EXACT []
synonym: "upregulation of seed germination" EXACT []
is_a: GO:0010029 ! regulation of seed germination
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0009845 ! seed germination

[Term]
id: GO:0010031
name: circumnutation
namespace: biological_process
def: "The organismal movement by which the tip of a plant organ follows a spiral pattern as a consequence of growth." [GOC:mtg_MIT_16mar07, ISBN:0192801023]
is_a: GO:0050879 ! multicellular organismal movement

[Term]
id: GO:0010032
name: meiotic chromosome condensation
namespace: biological_process
def: "Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401]
is_a: GO:0030261 ! chromosome condensation

[Term]
id: GO:0010033
name: response to organic substance
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm]
subset: gosubset_prok
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0010034
name: response to acetate
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:sm]
subset: gosubset_prok
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0010035
name: response to inorganic substance
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:sm]
subset: gosubset_prok
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0010036
name: response to boron
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a boron stimulus." [GOC:sm]
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0010037
name: response to carbon dioxide
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:sm]
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0010038
name: response to metal ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm]
subset: gosubset_prok
synonym: "heavy metal sensitivity/resistance" RELATED []
synonym: "response to heavy metal" NARROW []
synonym: "response to metal" EXACT []
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0010039
name: response to iron ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:sm]
synonym: "response to iron" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010040
name: response to iron(II) ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus." [GOC:sm]
synonym: "response to iron(II)" EXACT []
is_a: GO:0010039 ! response to iron ion

[Term]
id: GO:0010041
name: response to iron(III) ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus." [GOC:sm]
synonym: "response to iron(III)" EXACT []
is_a: GO:0010039 ! response to iron ion

[Term]
id: GO:0010042
name: response to manganese ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:sm]
synonym: "response to manganese" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010043
name: response to zinc ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm]
synonym: "response to zinc" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010044
name: response to aluminum ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus." [GOC:sm]
synonym: "response to aluminium ion" EXACT []
synonym: "response to aluminum" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010045
name: response to nickel ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel ion stimulus." [GOC:sm]
synonym: "response to nickel" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010046
name: response to mycotoxin
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin are a toxic chemical substance produced by fungi." [GOC:sm]
is_a: GO:0009636 ! response to toxin

[Term]
id: GO:0010047
name: fruit dehiscence
namespace: biological_process
def: "The process leading to the spontaneous opening of the fruit permitting the escape of seeds." [GOC:tb, ISBN:0471245208]
is_a: GO:0009900 ! dehiscence

[Term]
id: GO:0010048
name: vernalization response
namespace: biological_process
def: "The process of thermal induction in plants in which flowering is promoted by exposure to low temperatures." [GOC:tair_curators, ISBN:0521591392]
is_a: GO:0009409 ! response to cold

[Term]
id: GO:0010049
name: acquisition of reproductive competence
namespace: biological_process
def: "The process by which a plant acquires the ability to respond to a floral inductive signal." [GOC:tair_curators]
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0010050
name: vegetative phase change
namespace: biological_process
def: "Any process involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tb]
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0010051
name: xylem and phloem pattern formation
namespace: biological_process
def: "The regionalization process that gives rise to the patterning of the conducting tissues. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb]
synonym: "vascular tissue pattern formation" EXACT []
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0010052
name: guard cell differentiation
namespace: biological_process
def: "The process whereby a guard mother cell acquires the specialized features of a guard cell." [GOC:expert_db, GOC:tb]
synonym: "stomatal cell differentiation" RELATED []
is_a: GO:0009913 ! epidermal cell differentiation
relationship: part_of GO:0010103 ! stomatal complex morphogenesis

[Term]
id: GO:0010053
name: root epidermal cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast." [GOC:tb]
is_a: GO:0009913 ! epidermal cell differentiation
relationship: part_of GO:0010015 ! root morphogenesis

[Term]
id: GO:0010054
name: trichoblast differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a trichoblast, a root epidermal cell that will give rise to a root hair." [GOC:tb]
synonym: "trichoblast cell differentiation" EXACT []
is_a: GO:0010053 ! root epidermal cell differentiation

[Term]
id: GO:0010055
name: atrichoblast differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of an atrichoblast, a root epidermal cell that will not give rise to a root hair." [GOC:tb]
is_a: GO:0010053 ! root epidermal cell differentiation

[Term]
id: GO:0010056
name: atrichoblast fate specification
namespace: biological_process
def: "The process involved in the specification of an atrichoblast." [GOC:tb]
is_a: GO:0009957 ! epidermal cell fate specification
relationship: part_of GO:0010055 ! atrichoblast differentiation

[Term]
id: GO:0010057
name: trichoblast fate specification
namespace: biological_process
def: "The process involved in the specification of a trichoblast." [GOC:tb]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0010054 ! trichoblast differentiation

[Term]
id: GO:0010058
name: regulation of atrichoblast fate specification
namespace: biological_process
def: "Any process that modulates atrichoblast fate specification." [GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:0045604 ! regulation of epidermal cell differentiation
relationship: regulates GO:0010056 ! atrichoblast fate specification

[Term]
id: GO:0010059
name: positive regulation of atrichoblast fate specification
namespace: biological_process
def: "Any process that induces or promotes atrichoblast fate specification." [GOC:tb]
synonym: "activation of atrichoblast fate" NARROW []
synonym: "stimulation of atrichoblast fate" NARROW []
synonym: "up regulation of atrichoblast fate" EXACT []
synonym: "up-regulation of atrichoblast fate" EXACT []
synonym: "upregulation of atrichoblast fate" EXACT []
is_a: GO:0010058 ! regulation of atrichoblast fate specification
is_a: GO:0042660 ! positive regulation of cell fate specification
relationship: positively_regulates GO:0010056 ! atrichoblast fate specification

[Term]
id: GO:0010060
name: negative regulation of atrichoblast fate specification
namespace: biological_process
def: "Any process that suppresses atrichoblast fate specification." [GOC:tb]
synonym: "down regulation of atrichoblast fate" EXACT []
synonym: "down-regulation of atrichoblast fate" EXACT []
synonym: "downregulation of atrichoblast fate" EXACT []
synonym: "inhibition of atrichoblast fate" NARROW []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0010058 ! regulation of atrichoblast fate specification
relationship: negatively_regulates GO:0010056 ! atrichoblast fate specification

[Term]
id: GO:0010061
name: regulation of trichoblast fate specification
namespace: biological_process
def: "Any process that modulates trichoblast fate specification." [GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:0045604 ! regulation of epidermal cell differentiation
relationship: regulates GO:0010057 ! trichoblast fate specification

[Term]
id: GO:0010062
name: negative regulation of trichoblast fate specification
namespace: biological_process
def: "Any process that suppresses trichoblast fate specification." [GOC:tb]
synonym: "down regulation of trichoblast fate" EXACT []
synonym: "down-regulation of trichoblast fate" EXACT []
synonym: "downregulation of trichoblast fate" EXACT []
synonym: "inhibition of trichoblast fate" NARROW []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0010061 ! regulation of trichoblast fate specification
relationship: negatively_regulates GO:0010057 ! trichoblast fate specification

[Term]
id: GO:0010063
name: positive regulation of trichoblast fate specification
namespace: biological_process
def: "Any process that induces or promotes trichoblast fate specification." [GOC:tb]
synonym: "activation of trichoblast fate" NARROW []
synonym: "stimulation of trichoblast fate" NARROW []
synonym: "up regulation of trichoblast fate" EXACT []
synonym: "up-regulation of trichoblast fate" EXACT []
synonym: "upregulation of trichoblast fate" EXACT []
is_a: GO:0010061 ! regulation of trichoblast fate specification
is_a: GO:0042660 ! positive regulation of cell fate specification
relationship: positively_regulates GO:0010057 ! trichoblast fate specification

[Term]
id: GO:0010064
name: embryonic shoot morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of embryonic shoot are generated and organized. Morphogenesis pertains to the creation of form." [GOC:tb]
is_a: GO:0010016 ! shoot morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0010065
name: primary meristem tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of primary meristem over time, from formation to the mature structure, as it occurs during plant embryogenesis. The primary meristem tissue is the protoderm, ground meristem and procambium." [GOC:tb, ISBN:0471245208]
synonym: "primary meristem histogenesis" EXACT []
is_a: GO:0048508 ! embryonic meristem development

[Term]
id: GO:0010066
name: ground meristem histogenesis
namespace: biological_process
def: "The formation of the primary meristem or meristematic tissue that gives rise to the ground tissues." [GOC:tb, ISBN:0471245208]
is_a: GO:0010065 ! primary meristem tissue development

[Term]
id: GO:0010067
name: procambium histogenesis
namespace: biological_process
def: "The formation of the primary meristem or meristematic tissue that gives rise to the primary vascular tissue." [GOC:tb, ISBN:0471245208]
is_a: GO:0010065 ! primary meristem tissue development

[Term]
id: GO:0010068
name: protoderm histogenesis
namespace: biological_process
def: "The formation of the primary meristem or meristematic tissue that gives rise to the epidermis." [GOC:tb, ISBN:0471245208]
is_a: GO:0010065 ! primary meristem tissue development

[Term]
id: GO:0010069
name: zygote asymmetric cytokinesis in the embryo sac
namespace: biological_process
def: "The division of the zygote in a plane perpendicular to the long axis of the embryo sac to produce a larger basal cell near the micropyle and a small terminal cell close to what was the central cell and is now the developing endosperm. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb, ISBN:0865427429]
is_a: GO:0010070 ! zygote asymmetric cell division
is_a: GO:0033205 ! cytokinesis during cell cycle
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0009793 ! embryonic development ending in seed dormancy

[Term]
id: GO:0010070
name: zygote asymmetric cell division
namespace: biological_process
def: "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials." [GOC:tb]
synonym: "zygote asymmetric cytokinesis" RELATED []
is_a: GO:0008356 ! asymmetric cell division

[Term]
id: GO:0010071
name: root meristem specification
namespace: biological_process
def: "The specification of a meristem which will give rise to a primary or lateral root." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010014 ! meristem initiation
relationship: part_of GO:0010015 ! root morphogenesis
relationship: part_of GO:0048508 ! embryonic meristem development

[Term]
id: GO:0010072
name: primary shoot apical meristem specification
namespace: biological_process
def: "The specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers." [GOC:ascb_2009, GOC:dph, GOC:tair_curators, GOC:tb]
is_a: GO:0010014 ! meristem initiation
relationship: part_of GO:0010016 ! shoot morphogenesis
relationship: part_of GO:0048508 ! embryonic meristem development

[Term]
id: GO:0010073
name: meristem maintenance
namespace: biological_process
def: "Any process involved in maintaining the identity, size and shape of a meristem." [GOC:tb]
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0048507 ! meristem development

[Term]
id: GO:0010074
name: maintenance of meristem identity
namespace: biological_process
alt_id: GO:0032503
def: "The process by which an organism retains a population of meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:tb]
synonym: "maintenance of meristem cell identity" EXACT []
synonym: "meristem cell maintenance" EXACT []
is_a: GO:0019827 ! stem cell maintenance
relationship: part_of GO:0010073 ! meristem maintenance

[Term]
id: GO:0010075
name: regulation of meristem growth
namespace: biological_process
def: "Any process involved in maintaining the size and shape of a meristem." [GOC:tb]
synonym: "regulation of meristem size" EXACT [GOC:tb]
is_a: GO:0048509 ! regulation of meristem development
is_a: GO:0048638 ! regulation of developmental growth
relationship: part_of GO:0010073 ! meristem maintenance
relationship: regulates GO:0035266 ! meristem growth

[Term]
id: GO:0010076
name: maintenance of floral meristem identity
namespace: biological_process
def: "The process by which an organism retains a population of floral meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb]
is_a: GO:0010074 ! maintenance of meristem identity

[Term]
id: GO:0010077
name: maintenance of inflorescence meristem identity
namespace: biological_process
def: "The process by which an organism retains a population of inflorescence meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb]
is_a: GO:0010074 ! maintenance of meristem identity

[Term]
id: GO:0010078
name: maintenance of root meristem identity
namespace: biological_process
def: "The process by which an organism retains a population of root meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb]
is_a: GO:0010074 ! maintenance of meristem identity
relationship: part_of GO:0010015 ! root morphogenesis

[Term]
id: GO:0010079
name: maintenance of vegetative meristem identity
namespace: biological_process
def: "The process by which an organism retains a population of vegetative meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb]
is_a: GO:0010074 ! maintenance of meristem identity

[Term]
id: GO:0010080
name: regulation of floral meristem growth
namespace: biological_process
def: "Any process involved in maintaining the size and shape of a floral meristem." [GOC:tb]
synonym: "regulation of floral meristem size" EXACT []
is_a: GO:0009909 ! regulation of flower development
is_a: GO:0010075 ! regulation of meristem growth
relationship: regulates GO:0010451 ! floral meristem growth

[Term]
id: GO:0010081
name: regulation of inflorescence meristem growth
namespace: biological_process
def: "Any process involved in maintaining the size and shape of an inflorescence meristem." [GOC:tb]
synonym: "regulation of inflorescence meristem size" EXACT [GOC:tb]
is_a: GO:0010075 ! regulation of meristem growth
is_a: GO:0048580 ! regulation of post-embryonic development
relationship: regulates GO:0010450 ! inflorescence meristem growth

[Term]
id: GO:0010082
name: regulation of root meristem growth
namespace: biological_process
def: "Any process involved in maintaining the size and shape of a root meristem." [GOC:tb]
synonym: "regulation of root meristem size" EXACT [GOC:tb]
is_a: GO:0010075 ! regulation of meristem growth
relationship: part_of GO:0010015 ! root morphogenesis
relationship: regulates GO:0010449 ! root meristem growth

[Term]
id: GO:0010083
name: regulation of vegetative meristem growth
namespace: biological_process
def: "Any process involved in maintaining the size and shape of a vegetative meristem." [GOC:tb]
synonym: "regulation of vegetative meristem size" EXACT [GOC:tb]
is_a: GO:0010075 ! regulation of meristem growth
is_a: GO:0048831 ! regulation of shoot development
relationship: regulates GO:0010448 ! vegetative meristem growth

[Term]
id: GO:0010084
name: specification of organ axis polarity
namespace: biological_process
def: "The process by which the polarity of an organ axis is specified." [GOC:tb]
is_a: GO:0065001 ! specification of axis polarity
relationship: part_of GO:0009887 ! organ morphogenesis

[Term]
id: GO:0010085
name: polarity specification of proximal/distal axis
namespace: biological_process
def: "Any process resulting in the establishment of polarity along the proximal/distal axis." [GOC:tb]
is_a: GO:0065001 ! specification of axis polarity
relationship: part_of GO:0009946 ! proximal/distal axis specification

[Term]
id: GO:0010086
name: embryonic root morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the embryonic root are generated and organized. Morphogenesis pertains to the creation of form." [GOC:tb]
is_a: GO:0010015 ! root morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0010087
name: phloem or xylem histogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of phloem and/or xylem over time, from formation to the mature structure. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb]
synonym: "phloem or xylem histogenesis" EXACT [GOC:tb]
synonym: "vascular tissue development" BROAD []
synonym: "vascular tissue histogenesis" EXACT []
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0010088
name: phloem development
namespace: biological_process
def: "The formation of the principal food-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208]
synonym: "phloem histogenesis" EXACT [GOC:tb]
is_a: GO:0010087 ! phloem or xylem histogenesis

[Term]
id: GO:0010089
name: xylem development
namespace: biological_process
def: "The formation of the principal water-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208]
synonym: "xylem histogenesis" EXACT [GOC:tb]
is_a: GO:0010087 ! phloem or xylem histogenesis

[Term]
id: GO:0010090
name: trichome morphogenesis
namespace: biological_process
alt_id: GO:0048272
def: "The process by which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tair_curators]
synonym: "trichome cell morphogenesis during differentiation" EXACT []
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0010026 ! trichome differentiation

[Term]
id: GO:0010091
name: trichome branching
namespace: biological_process
alt_id: GO:0048274
def: "Any process involved in the formation of branches in plant hair cells. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tair_curators]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0010090 ! trichome morphogenesis

[Term]
id: GO:0010092
name: specification of organ identity
namespace: biological_process
def: "The regionalization process by which the identity of an organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0048645 ! organ formation

[Term]
id: GO:0010093
name: specification of floral organ identity
namespace: biological_process
def: "The process by which the identity of a floral organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb]
is_a: GO:0010092 ! specification of organ identity
relationship: part_of GO:0048449 ! floral organ formation

[Term]
id: GO:0010094
name: specification of carpel identity
namespace: biological_process
def: "The process by which a floral organ primordium acquires the carpel identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators]
is_a: GO:0010093 ! specification of floral organ identity
relationship: part_of GO:0048462 ! carpel formation

[Term]
id: GO:0010095
name: specification of petal identity
namespace: biological_process
def: "The process by which a floral organ primordium acquires petal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators]
is_a: GO:0010093 ! specification of floral organ identity
relationship: part_of GO:0048451 ! petal formation

[Term]
id: GO:0010096
name: specification of sepal identity
namespace: biological_process
def: "The process by which a floral organ primordium acquires sepal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators]
is_a: GO:0010093 ! specification of floral organ identity
relationship: part_of GO:0048453 ! sepal formation

[Term]
id: GO:0010097
name: specification of stamen identity
namespace: biological_process
def: "The process by which a floral organ primordium acquires stamen or staminode identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators]
is_a: GO:0010093 ! specification of floral organ identity
relationship: part_of GO:0048455 ! stamen formation

[Term]
id: GO:0010098
name: suspensor development
namespace: biological_process
def: "The process whose specific outcome is the progression of the suspensor over time, from its formation to the mature structure. The suspensor is the extension at the base of the embryo that anchors the embryo in the embryo sac and pushes it into the endosperm." [GOC:tb, ISBN:0471245208]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0010099
name: regulation of photomorphogenesis
namespace: biological_process
def: "Any process that modulates the rate or extent of photomorphogenesis." [GOC:tb]
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0009640 ! photomorphogenesis

[Term]
id: GO:0010100
name: negative regulation of photomorphogenesis
namespace: biological_process
def: "Any process that stops, reduces or prevents photomorphogenesis." [GOC:tb]
synonym: "down regulation of photomorphogenesis" EXACT []
synonym: "down-regulation of photomorphogenesis" EXACT []
synonym: "downregulation of photomorphogenesis" EXACT []
synonym: "inhibition of photomorphogenesis" NARROW []
is_a: GO:0010099 ! regulation of photomorphogenesis
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0009640 ! photomorphogenesis

[Term]
id: GO:0010101
name: post-embryonic root morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the post-embryonic root are generated and organized. Morphogenesis pertains to the creation of form. The post-embryonic root is the root formed after the embryonic phase has been completed." [GOC:tb]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0010015 ! root morphogenesis
relationship: part_of GO:0048528 ! post-embryonic root development

[Term]
id: GO:0010102
name: lateral root morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of lateral root are generated and organized. Morphogenesis pertains to the creation of form. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper." [GOC:tair_curators]
is_a: GO:0010101 ! post-embryonic root morphogenesis
relationship: part_of GO:0048527 ! lateral root development

[Term]
id: GO:0010103
name: stomatal complex morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the stomatal complex are generated and organized. Morphogenesis pertains to the creation of form. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [GOC:tair_curators]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0010016 ! shoot morphogenesis
relationship: part_of GO:0010374 ! stomatal complex development

[Term]
id: GO:0010104
name: regulation of ethylene mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ethylene (ethene) mediated signaling." [GOC:tb]
synonym: "regulation of ethene mediated signaling pathway" EXACT []
synonym: "regulation of ethene mediated signalling pathway" EXACT []
synonym: "regulation of ethylene mediated signalling pathway" EXACT []
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0070297 ! regulation of two-component signal transduction system (phosphorelay)
relationship: regulates GO:0009873 ! ethylene mediated signaling pathway

[Term]
id: GO:0010105
name: negative regulation of ethylene mediated signaling pathway
namespace: biological_process
def: "Any process that stops or prevents ethylene (ethene) mediated signaling." [GOC:tb]
synonym: "down regulation of ethylene mediated signaling pathway" EXACT []
synonym: "down-regulation of ethylene mediated signaling pathway" EXACT []
synonym: "downregulation of ethylene mediated signaling pathway" EXACT []
synonym: "inhibition of ethylene mediated signaling pathway" NARROW []
synonym: "negative regulation of ethene mediated signaling pathway" EXACT []
synonym: "negative regulation of ethene mediated signalling pathway" EXACT []
synonym: "negative regulation of ethylene mediated signalling pathway" EXACT []
is_a: GO:0010104 ! regulation of ethylene mediated signaling pathway
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0070298 ! negative regulation of two-component signal transduction system (phosphorelay)
relationship: negatively_regulates GO:0009873 ! ethylene mediated signaling pathway

[Term]
id: GO:0010106
name: cellular response to iron ion starvation
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions." [GOC:mg]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0010107
name: potassium ion import
namespace: biological_process
def: "The directed movement of potassium ions into a cell or organelle." [GOC:sm]
synonym: "potassium import" EXACT []
synonym: "potassium ion uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006813 ! potassium ion transport

[Term]
id: GO:0010108
name: detection of glutamine
namespace: biological_process
def: "The series of events in which a glutamine stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "glutamine detection" EXACT []
synonym: "glutamine perception" RELATED []
synonym: "glutamine sensing" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0010109
name: regulation of photosynthesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of photosynthesis." [GOC:sm]
subset: gosubset_prok
is_a: GO:0031323 ! regulation of cellular metabolic process
relationship: regulates GO:0015979 ! photosynthesis

[Term]
id: GO:0010110
name: regulation of photosynthesis, dark reaction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of photosynthesis dark reaction." [GOC:sm]
is_a: GO:0010109 ! regulation of photosynthesis
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
relationship: regulates GO:0019685 ! photosynthesis, dark reaction

[Term]
id: GO:0010111
name: glyoxysome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the glyoxysome. A glyoxysome is a microbody that contains the enzymes of the glyoxylate pathway." [GOC:tb]
synonym: "glyoxysome organisation" EXACT [GOC:curators]
synonym: "glyoxysome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0010112
name: regulation of systemic acquired resistance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of systemic acquired resistance." [GOC:sm]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0045088 ! regulation of innate immune response
relationship: regulates GO:0009627 ! systemic acquired resistance

[Term]
id: GO:0010113
name: negative regulation of systemic acquired resistance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of systemic acquired resistance." [GOC:sm]
synonym: "down regulation of systemic acquired resistance" EXACT []
synonym: "down-regulation of systemic acquired resistance" EXACT []
synonym: "downregulation of systemic acquired resistance" EXACT []
synonym: "inhibition of systemic acquired resistance" NARROW []
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0010112 ! regulation of systemic acquired resistance
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0045824 ! negative regulation of innate immune response
relationship: negatively_regulates GO:0009627 ! systemic acquired resistance

[Term]
id: GO:0010114
name: response to red light
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm]
synonym: "response to red light stimulus" EXACT []
is_a: GO:0009639 ! response to red or far red light

[Term]
id: GO:0010115
name: regulation of abscisic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm]
subset: gosubset_prok
synonym: "regulation of abscisic acid anabolism" EXACT []
synonym: "regulation of abscisic acid biosynthesis" EXACT []
synonym: "regulation of abscisic acid formation" EXACT []
synonym: "regulation of abscisic acid synthesis" EXACT []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043455 ! regulation of secondary metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: regulates GO:0009688 ! abscisic acid biosynthetic process

[Term]
id: GO:0010116
name: positive regulation of abscisic acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm]
subset: gosubset_prok
synonym: "activation of abscisic acid biosynthetic process" NARROW []
synonym: "positive regulation of abscisic acid anabolism" EXACT []
synonym: "positive regulation of abscisic acid biosynthesis" EXACT []
synonym: "positive regulation of abscisic acid formation" EXACT []
synonym: "positive regulation of abscisic acid synthesis" EXACT []
synonym: "stimulation of abscisic acid biosynthetic process" NARROW []
synonym: "up regulation of abscisic acid biosynthetic process" EXACT []
synonym: "up-regulation of abscisic acid biosynthetic process" EXACT []
synonym: "upregulation of abscisic acid biosynthetic process" EXACT []
is_a: GO:0010115 ! regulation of abscisic acid biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
relationship: positively_regulates GO:0009688 ! abscisic acid biosynthetic process

[Term]
id: GO:0010117
name: photoprotection
namespace: biological_process
def: "Protection mechanism used by plants under conditions of excess energy absorption as a consequence of the light reactions of photosynthesis." [GOC:mg]
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0010118
name: stomatal movement
namespace: biological_process
def: "The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata)." [GOC:sm]
subset: goslim_pir
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0010119
name: regulation of stomatal movement
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stomatal movement." [GOC:sm]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0010118 ! stomatal movement

[Term]
id: GO:0010120
name: camalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of camalexin, an indole phytoalexin." [GOC:pz]
synonym: "camalexin anabolism" EXACT []
synonym: "camalexin biosynthesis" EXACT []
synonym: "camalexin formation" EXACT []
synonym: "camalexin synthesis" EXACT []
xref: MetaCyc:CAMALEXIN-SYN
is_a: GO:0009700 ! indole phytoalexin biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0052317 ! camalexin metabolic process

[Term]
id: GO:0010121
name: arginine catabolic process to proline via ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine." [GOC:pz]
subset: gosubset_prok
synonym: "arginine breakdown to proline via ornithine" EXACT []
synonym: "arginine degradation to proline via ornithine" EXACT []
xref: MetaCyc:ARGORNPROST-PWY
is_a: GO:0019493 ! arginine catabolic process to proline

[Term]
id: GO:0010122
name: arginine catabolic process to alanine via ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including alanine, via ornithine." [GOC:pz]
subset: gosubset_prok
synonym: "arginine breakdown to alanine via ornithine" EXACT []
synonym: "arginine degradation to alanine via ornithine" EXACT []
xref: MetaCyc:ARGORNPROST-PWY
is_a: GO:0006527 ! arginine catabolic process

[Term]
id: GO:0010123
name: acetate catabolic process to butyrate, ethanol, acetone and butanol
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate to form butyrate, ethanol, acetone and butanol." [GOC:pz]
subset: gosubset_prok
synonym: "acetate fermentation to butyrate, ethanol, acetone and butanol" EXACT []
xref: MetaCyc:CENTFERM-PWY
is_a: GO:0019654 ! acetate fermentation

[Term]
id: GO:0010124
name: phenylacetate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylacetate." [GOC:pz]
subset: gosubset_prok
synonym: "phenylacetate breakdown" EXACT []
synonym: "phenylacetate catabolism" EXACT []
synonym: "phenylacetate degradation" EXACT []
xref: MetaCyc:PWY0-321
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0010125
name: mycothiol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz]
subset: gosubset_prok
synonym: "mycothiol anabolism" EXACT []
synonym: "mycothiol biosynthesis" EXACT []
synonym: "mycothiol formation" EXACT []
synonym: "mycothiol synthesis" EXACT []
xref: MetaCyc:PWY1G-0
is_a: GO:0010126 ! mycothiol metabolic process
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0010126
name: mycothiol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz]
subset: gosubset_prok
synonym: "mycothiol metabolism" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0010127
name: mycothiol-dependent detoxification
namespace: biological_process
def: "The chemical reactions using mycothiol to convert an alkylating agent to an S-conjugate of mycothiol. The latter is cleaved to release mercapturic acid which is excreted from the cell." [GOC:pz]
synonym: "mycothiol-dependent detoxification of alkylating agent" NARROW []
xref: MetaCyc:PWY1G-1
xref: MetaCyc:PWY1G-170
is_a: GO:0009636 ! response to toxin

[Term]
id: GO:0010128
name: benzoate catabolic process via CoA ligation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway." [GOC:pz]
subset: gosubset_prok
synonym: "anaerobic benzoate breakdown" EXACT []
synonym: "anaerobic benzoate catabolic process" EXACT []
synonym: "anaerobic benzoate catabolism" EXACT []
synonym: "anaerobic benzoate degradation" EXACT []
xref: MetaCyc:PWY-283
is_a: GO:0018875 ! anaerobic benzoate metabolic process
is_a: GO:0043639 ! benzoate catabolic process

[Term]
id: GO:0010129
name: anaerobic cyclohexane-1-carboxylate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyclohexane-1-carboxylate, a alicyclic acid, in the absence of oxygen." [GOC:pz]
subset: gosubset_prok
synonym: "anaerobic cyclohexane-1-carboxylate breakdown" EXACT []
synonym: "anaerobic cyclohexane-1-carboxylate catabolism" EXACT []
synonym: "anaerobic cyclohexane-1-carboxylate degradation" EXACT []
xref: MetaCyc:PWY-301
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0010130
name: anaerobic ethylbenzene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen." [GOC:pz]
subset: gosubset_prok
synonym: "anaerobic ethylbenzene breakdown" EXACT []
synonym: "anaerobic ethylbenzene catabolism" EXACT []
synonym: "anaerobic ethylbenzene degradation" EXACT []
xref: MetaCyc:PWY-481
is_a: GO:0018913 ! anaerobic ethylbenzene metabolic process
is_a: GO:0043451 ! alkene catabolic process

[Term]
id: GO:0010131
name: sucrose catabolic process, using invertase or sucrose synthase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sucrose by the enzymatic action of either invertase or sucrose synthase." [GOC:pz]
subset: gosubset_prok
synonym: "sucrose breakdown, using invertase or sucrose synthase" EXACT []
synonym: "sucrose catabolism, using invertase or sucrose synthase" EXACT []
synonym: "sucrose degradation, using invertase or sucrose synthase" EXACT []
xref: MetaCyc:PWY-3801
xref: MetaCyc:PWY-621
is_a: GO:0005987 ! sucrose catabolic process

[Term]
id: GO:0010132
name: dhurrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dhurrin, a cyanogenic glucoside which functions as a plant defense compound." [GOC:pz]
subset: gosubset_prok
synonym: "dhurrin anabolism" EXACT []
synonym: "dhurrin biosynthesis" EXACT []
synonym: "dhurrin formation" EXACT []
synonym: "dhurrin synthesis" EXACT []
xref: MetaCyc:PWY-861
is_a: GO:0019756 ! cyanogenic glycoside biosynthetic process

[Term]
id: GO:0010133
name: proline catabolic process to glutamate
namespace: biological_process
alt_id: GO:0019494
def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate." [GOC:pz]
subset: gosubset_prok
synonym: "proline breakdown to glutamate" EXACT []
synonym: "proline degradation to glutamate" EXACT []
synonym: "proline oxidation" RELATED []
xref: MetaCyc:PROUT-PWY
xref: MetaCyc:PWY-4561
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0006562 ! proline catabolic process

[Term]
id: GO:0010134
name: sulfate assimilation via adenylyl sulfate reduction
namespace: biological_process
def: "The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase." [EC:1.8.99.2]
subset: gosubset_prok
synonym: "sulphate assimilation via adenylyl sulphate reduction" EXACT []
xref: MetaCyc:SULFMETII-PWY
is_a: GO:0000103 ! sulfate assimilation
is_a: GO:0019419 ! sulfate reduction

[Term]
id: GO:0010135
name: ureide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ureide, allantoin and allantoate, which are the organic forms of nitrogen in nitrogen fixing and transporting plants." [GOC:pz]
subset: gosubset_prok
synonym: "ureide metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0010136
name: ureide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium." [GOC:pz]
subset: gosubset_prok
synonym: "ureide breakdown" EXACT []
synonym: "ureide catabolism" EXACT []
synonym: "ureide degradation" EXACT []
xref: MetaCyc:URDEGR-PWY
is_a: GO:0010135 ! ureide metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process

[Term]
id: GO:0010137
name: ureide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ureide, the organic form of nitrogen in nitrogen fixing and transporting plants, from IMP, which is synthesized de novo during nitrogen fixation by roots." [GOC:pz]
subset: gosubset_prok
synonym: "ureide anabolism" EXACT []
synonym: "ureide biosynthesis" EXACT []
synonym: "ureide formation" EXACT []
synonym: "ureide synthesis" EXACT []
xref: MetaCyc:URSIN-PWY
is_a: GO:0010135 ! ureide metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process

[Term]
id: GO:0010138
name: pyrimidine ribonucleotide salvage
namespace: biological_process
def: "The pathway by which pyrimidine bases or pyrimidine ribonucleosides from pyrimidine nucleotide breakdown are converted back to pyrimidine ribonucleotides. The salvage pathway is important where there is no de novo pyrimidine nucleotide biosynthesis." [GOC:pz]
subset: gosubset_prok
xref: MetaCyc:PWY0-163
is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process
is_a: GO:0032262 ! pyrimidine nucleotide salvage

[Term]
id: GO:0010139
name: pyrimidine deoxyribonucleotide salvage
namespace: biological_process
def: "The pathway by which pyrimidine bases or pyrimidine deoxyribonucleotides from pyrimidine nucleotide breakdown are converted back to pyrimidine deoxyribonucleotides. The salvage pathway is important where there is no de novo pyrimidine deoxyribonucleotide biosynthesis." [GOC:pz]
subset: gosubset_prok
xref: MetaCyc:PWY0-181
is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process
is_a: GO:0032262 ! pyrimidine nucleotide salvage

[Term]
id: GO:0010140
name: adenine, hypoxanthine and their nucleoside salvage
namespace: biological_process
def: "OBSOLETE. The pathway by which adenine, hypoxanthine and their nucleosides from purine nucleotides breakdown are converted back to purine nucleotides. The salvage pathway is important where there is no de-novo purine nucleotide biosynthesis." [GOC:pz]
comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology.
is_obsolete: true
replaced_by: GO:0006168
replaced_by: GO:0006169
replaced_by: GO:0006190
replaced_by: GO:0043103

[Term]
id: GO:0010141
name: guanine, xanthine and their nucleoside salvage
namespace: biological_process
def: "OBSOLETE. The pathway by which guanine, xanthine and their nucleoside from purine nucleotides breakdown are converted back to purine nucleotides. The pathway is important in cells where there is no de-novo purine nucleotides biosynthesis." [GOC:pz]
comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology.
is_obsolete: true
replaced_by: GO:0006178
replaced_by: GO:0006179
replaced_by: GO:0006190
replaced_by: GO:0043103

[Term]
id: GO:0010142
name: farnesyl diphosphate biosynthetic process, mevalonate pathway
namespace: biological_process
def: "The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols." [GOC:pz, MetaCyc:PWY-922]
subset: gosubset_prok
synonym: "Ac-MVA pathway" NARROW [PMID:14517367]
synonym: "acetate-mevalonate pathway" NARROW [PMID:14517367]
synonym: "farnesyl diphosphate anabolism, mevalonate pathway" EXACT []
synonym: "farnesyl diphosphate formation, mevalonate pathway" EXACT []
synonym: "farnesyl diphosphate synthesis, mevalonate pathway" EXACT []
synonym: "isoprenoid pathway" EXACT []
xref: MetaCyc:PWY-922
is_a: GO:0045337 ! farnesyl diphosphate biosynthetic process
relationship: part_of GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0010143
name: cutin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cutin, a waxy substance, which combined with cellulose forms a substance nearly impervious to water and constituting the cuticle in plants." [ISBN:0028623819]
synonym: "cutin anabolism" EXACT []
synonym: "cutin biosynthesis" EXACT []
synonym: "cutin formation" EXACT []
synonym: "cutin synthesis" EXACT []
xref: MetaCyc:PWY-321
is_a: GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0010144
name: pyridoxal phosphate biosynthetic process from pyridoxamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, the active form of vitamin B6, from pyridoxamine." [GOC:pz]
subset: gosubset_prok
synonym: "pyridoxal phosphate anabolism from pyridoxamine" EXACT []
synonym: "pyridoxal phosphate formation from pyridoxamine" EXACT []
synonym: "pyridoxal phosphate synthesis from pyridoxamine" EXACT []
synonym: "vitamin B6 biosynthesis from pyridoxamine" EXACT []
synonym: "vitamin B6 biosynthetic process from pyridoxamine" EXACT []
is_a: GO:0042818 ! pyridoxamine metabolic process
is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process

[Term]
id: GO:0010145
name: fructan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructan, a polysaccharide consisting of fructose residues." [GOC:sm]
subset: gosubset_prok
synonym: "fructan metabolism" EXACT []
synonym: "levan metabolic process" EXACT []
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0010146
name: fructan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fructan a polysaccharide consisting of fructose residues." [GOC:pz]
subset: gosubset_prok
synonym: "fructan anabolism" EXACT []
synonym: "fructan biosynthesis" EXACT []
synonym: "fructan formation" EXACT []
synonym: "fructan synthesis" EXACT []
synonym: "levan biosynthesis" EXACT []
synonym: "levan biosynthetic process" EXACT []
xref: MetaCyc:PWY-822
is_a: GO:0010145 ! fructan metabolic process
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process

[Term]
id: GO:0010147
name: fructan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructan, a polysaccharide consisting of fructose residues." [GOC:pz]
subset: gosubset_prok
synonym: "fructan breakdown" EXACT []
synonym: "fructan catabolism" EXACT []
synonym: "fructan degradation" EXACT []
synonym: "levan catabolic process" EXACT []
synonym: "levan catabolism" EXACT []
xref: MetaCyc:PWY-862
is_a: GO:0010145 ! fructan metabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process

[Term]
id: GO:0010148
name: transpiration
namespace: biological_process
def: "Release of water by the plant into the air as water vapor mainly through leaves." [GOC:sm, ISBN:0879015322]
xref: Wikipedia:Transpiration
is_a: GO:0006833 ! water transport

[Term]
id: GO:0010149
name: senescence
namespace: biological_process
def: "A preprogrammed process associated with the dismantling of an anatomical structure and an overall decline in metabolism. This may include the breakdown of organelles, membranes and other cellular components. An example of this process is found in Arabidopsis thaliana, when older leaves or floral organs are shed." [GOC:mtg_sensu, ISBN:0387987819]
xref: Wikipedia:Senescence
is_a: GO:0007568 ! aging

[Term]
id: GO:0010150
name: leaf senescence
namespace: biological_process
def: "The process that occurs in a leaf near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism." [ISBN:0387987819]
is_a: GO:0010260 ! organ senescence

[Term]
id: GO:0010151
name: chloroplast elongation
namespace: biological_process
def: "Expansion of the chloroplast that usually precedes division." [GOC:lr]
is_a: GO:0009658 ! chloroplast organization

[Term]
id: GO:0010152
name: pollen maturation
namespace: biological_process
def: "The final stages of microgametogenesis after the trinucleate stage has been reached resulting in viable pollen grains." [PMID:11595796]
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0009555 ! pollen development

[Term]
id: GO:0010153
name: polar cell elongation
namespace: biological_process
def: "OBSOLETE. Cell expansion that results in an increase in cell size along the axis of an organ in a polarized fashion." [PMID:11978864]
comment: This term was made obsolete because it did not represent a process discrete from its sibling terms.
synonym: "polarity-dependent cell elongation" NARROW []
is_obsolete: true
consider: GO:0042814
consider: GO:0042815

[Term]
id: GO:0010154
name: fruit development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fruit over time, from its formation to the mature structure. The fruit is a reproductive body of a seed plant." [GOC:sm]
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0010155
name: regulation of proton transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proton transport into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:sm]
is_a: GO:0043269 ! regulation of ion transport
relationship: regulates GO:0015992 ! proton transport

[Term]
id: GO:0010156
name: sporocyte morphogenesis
namespace: biological_process
def: "OBSOLETE. Formation and development of sporocyte, the haploid spores of angiosperms which are initiated by the differentiation of a subset of floral cells into sporocytes, which then undergo meiotic divisions to form microspores and megaspores." [PMID:10465788]
comment: This term was made obsolete because it was incorrectly defined.
is_obsolete: true
consider: GO:0048533

[Term]
id: GO:0010157
name: response to chlorate
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:sm]
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0010158
name: abaxial cell fate specification
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into an abaxial cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg]
is_a: GO:0001708 ! cell fate specification

[Term]
id: GO:0010159
name: specification of organ position
namespace: biological_process
def: "The regionalization process by which information that determines the correct position at which organ primordia are formed is generated and perceived resulting in correct positioning of the new organ." [PMID:9611175]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0009887 ! organ morphogenesis

[Term]
id: GO:0010160
name: formation of organ boundary
namespace: biological_process
alt_id: GO:0048862
def: "The regionalization process that specifies organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:dph, GOC:isa_complete, PMID:9611175]
synonym: "organ boundary specification" EXACT []
is_a: GO:0003002 ! regionalization
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0048645 ! organ formation

[Term]
id: GO:0010161
name: red light signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm]
synonym: "red light signalling pathway" EXACT []
is_a: GO:0010017 ! red or far-red light signaling pathway
is_a: GO:0071491 ! cellular response to red light

[Term]
id: GO:0010162
name: seed dormancy
namespace: biological_process
def: "The process by which a dormant state is induced, maintained and broken in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated." [GOC:lr]
xref: Wikipedia:Seed#Seed_dormancy_and_protection
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0022611 ! dormancy process
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0010431 ! seed maturation

[Term]
id: GO:0010163
name: high-affinity potassium ion import
namespace: biological_process
def: "The directed, energized, high affinity movement of potassium ions into a cell or organelle, driven by cation symport with hydrogen or sodium ions." [PMID:8893537]
synonym: "high affinity potassium ion import" EXACT []
synonym: "high affinity potassium ion uptake" EXACT [GOC:dph, GOC:tb]
synonym: "high-affinity potassium ion uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006813 ! potassium ion transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0010164
name: response to cesium ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus." [GOC:sm]
synonym: "response to cesium" EXACT [GOC:mah]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010165
name: response to X-ray
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray]
synonym: "response to X-ray radiation stimulus" EXACT []
is_a: GO:0010212 ! response to ionizing radiation

[Term]
id: GO:0010166
name: wax metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving wax, a compound containing C16 and C18 fatty acids." [GOC:sm]
subset: gosubset_prok
synonym: "wax metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0010167
name: response to nitrate
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:sm]
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0010168
name: ER body
namespace: cellular_component
def: "A novel compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:11577182]
synonym: "endoplasmic reticulum body" EXACT []
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0010169
name: thioglucosidase complex
namespace: cellular_component
def: "A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds." [PMID:10682349]
synonym: "myrosinase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0010170
name: glucose-1-phosphate adenylyltransferase complex
namespace: cellular_component
def: "Complex that catalyzes the synthesis of ADP-glucose and pyrophosphate from glucose-1-phosphate and ATP. In plants, the complex is a heterotetramer composed of two types of subunits (small and large). In bacteria, the enzyme complex is composed of four identical subunits." [GOC:tb, PMID:12748181]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0010171
name: body morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the soma are generated and organized. Morphogenesis pertains to the creation of form." [GOC:ems, ISBN:0140512888]
is_a: GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0010172
name: embryonic body morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the embryonic soma are generated and organized. Morphogenesis pertains to the creation of form." [GOC:ems]
is_a: GO:0010171 ! body morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0010174
name: nucleoside transmembrane transporter activity, against a concentration gradient
namespace: molecular_function
def: "Catalysis of the transfer of a nucleoside, from one side of a membrane to the other, up a concentration gradient." [GOC:tb]
synonym: "concentrative nucleoside transporter activity" EXACT []
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0010175
name: sphingosine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of amino alcohol sphingosine from one side of the membrane to the other." [GOC:tb]
is_a: GO:0005275 ! amine transmembrane transporter activity
is_a: GO:0015665 ! alcohol transmembrane transporter activity

[Term]
id: GO:0010176
name: homogentisate phytyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: homogentisic acid + phytyl diphosphate -> 2-methyl-6-phytylplastoquinol." [PMID:14512521]
is_a: GO:0010354 ! homogentisate prenyltransferase activity

[Term]
id: GO:0010177
name: methylthioalkylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: w-methylthio-2-oxoalkanoic acid + acetyl-CoA + H2O = 2-(w-methylthio)alkylmalate + CoA." [GOC:pz]
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0010178
name: IAA-amino acid conjugate hydrolase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid." [GOC:tb]
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0010179
name: IAA-Ala conjugate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: IAA-alanine -> indole-3-acetic acid + alanine." [GOC:tb]
xref: MetaCyc:RXN-2981
is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity

[Term]
id: GO:0010180
name: thioglucosidase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme thioglucosidase." [GOC:tb]
synonym: "myrosinase binding" EXACT []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0010181
name: FMN binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb]
subset: gosubset_prok
synonym: "flavin mononucleotide binding" EXACT []
is_a: GO:0000166 ! nucleotide binding
is_a: GO:0050662 ! coenzyme binding

[Term]
id: GO:0010182
name: sugar mediated signaling pathway
namespace: biological_process
def: "The process by which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes." [PMID:9014361]
synonym: "sugar mediated signalling" EXACT []
is_a: GO:0009756 ! carbohydrate mediated signaling

[Term]
id: GO:0010183
name: pollen tube guidance
namespace: biological_process
def: "The process by which the growth of pollen tube is directed towards the female gametophyte." [GOC:lr]
is_a: GO:0050918 ! positive chemotaxis
relationship: part_of GO:0048868 ! pollen tube development

[Term]
id: GO:0010184
name: cytokinin transport
namespace: biological_process
def: "The directed movement of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:lr]
is_a: GO:0006863 ! purine transport
is_a: GO:0009914 ! hormone transport

[Term]
id: GO:0010185
name: regulation of cellular defense response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular defense response." [GOC:sm]
synonym: "regulation of cellular defence response" EXACT []
is_a: GO:0031347 ! regulation of defense response
relationship: regulates GO:0006968 ! cellular defense response

[Term]
id: GO:0010186
name: positive regulation of cellular defense response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular defense response." [GOC:sm]
synonym: "activation of cellular defense response" NARROW []
synonym: "positive regulation of cellular defence response" EXACT []
synonym: "stimulation of cellular defense response" NARROW []
synonym: "up regulation of cellular defense response" EXACT []
synonym: "up-regulation of cellular defense response" EXACT []
synonym: "upregulation of cellular defense response" EXACT []
is_a: GO:0010185 ! regulation of cellular defense response
is_a: GO:0031349 ! positive regulation of defense response
relationship: positively_regulates GO:0006968 ! cellular defense response

[Term]
id: GO:0010187
name: negative regulation of seed germination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of seed germination." [GOC:tb]
synonym: "down regulation of seed germination" EXACT []
synonym: "down-regulation of seed germination" EXACT []
synonym: "downregulation of seed germination" EXACT []
synonym: "inhibition of seed germination" NARROW []
is_a: GO:0010029 ! regulation of seed germination
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0009845 ! seed germination

[Term]
id: GO:0010188
name: response to microbial phytotoxin
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microbial phytotoxin stimulus. A microbial phytotoxin is a chemical substance produced by microbes which is toxic to plants." [GOC:sm]
is_a: GO:0009636 ! response to toxin

[Term]
id: GO:0010189
name: vitamin E biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:mg]
subset: gosubset_prok
synonym: "alpha-tocopherol biosynthesis" NARROW []
synonym: "alpha-tocopherol biosynthetic process" NARROW []
synonym: "tocopherol biosynthesis" EXACT []
synonym: "tocopherol biosynthetic process" EXACT []
synonym: "vitamin E anabolism" EXACT []
synonym: "vitamin E biosynthesis" EXACT []
synonym: "vitamin E formation" EXACT []
synonym: "vitamin E synthesis" EXACT []
xref: MetaCyc:PWY-1422
is_a: GO:0042360 ! vitamin E metabolic process
is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process

[Term]
id: GO:0010190
name: cytochrome b6f complex assembly
namespace: biological_process
def: "Formation of cytochrome b6f complex, a complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen, by the aggregation, arrangement and bonding together of its constituents." [GOC:tb]
subset: gosubset_prok
synonym: "cytochrome b6f complex biogenesis" EXACT []
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0010191
name: mucilage metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mucilage, a gelatinous substance secreted by plants." [GOC:sm]
subset: goslim_pir
synonym: "mucilage metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0010192
name: mucilage biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mucilage, a gelatinous substance secreted by plants." [GOC:sm]
synonym: "mucilage anabolism" EXACT []
synonym: "mucilage biosynthesis" EXACT []
synonym: "mucilage formation" EXACT []
synonym: "mucilage synthesis" EXACT []
is_a: GO:0010191 ! mucilage metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0010193
name: response to ozone
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:sm]
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0010194
name: microRNA metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm]
comment: This term was made obsolete because it implies further processing of an end product rather than its production.
is_obsolete: true
replaced_by: GO:0035196

[Term]
id: GO:0010195
name: microRNA biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm]
comment: This term was made obsolete because it represents a process that is not known to occur.
synonym: "microRNA anabolism" EXACT []
synonym: "microRNA biosynthesis" EXACT []
synonym: "microRNA formation" EXACT []
synonym: "microRNA synthesis" EXACT []
synonym: "miRNA biosynthesis" EXACT []
synonym: "miRNA biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0035196

[Term]
id: GO:0010196
name: nonphotochemical quenching
namespace: biological_process
def: "The process to maintain the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage." [PMID:10667783]
is_a: GO:0009416 ! response to light stimulus

[Term]
id: GO:0010197
name: polar nucleus fusion
namespace: biological_process
def: "The merging of the polar nuclei, the two nuclei contained within the same cell that are created from the mitotic division of the megaspore during angiosperm reproduction. Polar nuclear fusion takes place in the ovule, forming in the fusion nucleus and giving rise to the endosperm when fertilized." [GOC:mtg_plant, GOC:sm]
is_a: GO:0000741 ! karyogamy
relationship: part_of GO:0009559 ! embryo sac central cell differentiation

[Term]
id: GO:0010198
name: synergid death
namespace: biological_process
alt_id: GO:0048470
def: "Synergid cells undergo degeneration and death in response to penetration by the pollen tube. It is an active process that involves a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles." [GOC:isa_complete, GOC:sm, PMID:12215516]
synonym: "synergid cell death" EXACT []
synonym: "synergid degeneration" EXACT []
is_a: GO:0010623 ! developmental programmed cell death
relationship: part_of GO:0009856 ! pollination

[Term]
id: GO:0010199
name: organ boundary specification between lateral organs and the meristem
namespace: biological_process
def: "The process by which boundaries between lateral organs and the meristem is established and maintained." [PMID:12068116]
synonym: "organ boundary specification" BROAD []
is_a: GO:0010160 ! formation of organ boundary

[Term]
id: GO:0010200
name: response to chitin
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:sm]
is_a: GO:0009743 ! response to carbohydrate stimulus

[Term]
id: GO:0010201
name: response to continuous far red light stimulus by the high-irradiance response system
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a continuous far red light stimulus by the high-irradiance response system. Far red light is electromagnetic radiation of wavelength 700-800nm. The activity of the high-irradiance response system is characterized by stronger effects of continuous than pulsed light at equal total fluence." [GOC:mtg_far_red, GOC:sm]
is_a: GO:0010218 ! response to far red light

[Term]
id: GO:0010202
name: response to low fluence red light stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Low fluence red light is defined in this case as short pulses of red light followed by darkness, providing a light level of 0.001-0.1 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm]
is_a: GO:0009645 ! response to low light intensity stimulus
is_a: GO:0010114 ! response to red light

[Term]
id: GO:0010203
name: response to very low fluence red light stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Very low fluence red light is defined in this case as short pulses of red light followed by darkness, providing light levels of less than 0.001 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm]
is_a: GO:0010114 ! response to red light
is_a: GO:0055122 ! response to very low light intensity stimulus

[Term]
id: GO:0010204
name: defense response signaling pathway, resistance gene-independent
namespace: biological_process
def: "A series of molecular signals that is activated during defense response and does not depend upon R-genes." [GOC:mah, GOC:sm]
synonym: "defence response signaling pathway, resistance gene-independent" EXACT []
synonym: "defence response signalling pathway, resistance gene-independent" EXACT []
is_a: GO:0002218 ! activation of innate immune response
is_a: GO:0007242 ! intracellular signaling cascade

[Term]
id: GO:0010205
name: photoinhibition
namespace: biological_process
def: "The mechanism by which high light intensity inhibits photosynthesis through inactivation of the D1 protein of photosystem II." [GOC:mtg_electron_transport, PMID:12068126]
synonym: "photosystem II inhibition" BROAD []
xref: Wikipedia:Photoinhibition
is_a: GO:0009644 ! response to high light intensity
is_a: GO:0043155 ! negative regulation of photosynthesis, light reaction
relationship: negatively_regulates GO:0009767 ! photosynthetic electron transport chain

[Term]
id: GO:0010206
name: photosystem II repair
namespace: biological_process
def: "Proteolysis of the damaged D1 protein and re-assembly of a new D1 subunit in the Photosystem II following photoinhibition." [GOC:sm]
is_a: GO:0030091 ! protein repair
relationship: part_of GO:0009765 ! photosynthesis, light harvesting

[Term]
id: GO:0010207
name: photosystem II assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a photosystem II complex on thylakoid membrane. In plants, the photosystem II complex consists of over 20 polypeptides encoded by either nuclear or chloroplast genome." [GOC:pz]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0010208
name: pollen wall assembly
namespace: biological_process
def: "The formation of reticulate pollen wall pattern consisting of two layers, exine and intine." [PMID:11743117]
synonym: "pollen wall formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0045229 ! external encapsulating structure organization
relationship: part_of GO:0009555 ! pollen development

[Term]
id: GO:0010209
name: vacuolar sorting signal binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole." [GOC:mah]
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0010210
name: IAA-Phe conjugate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: IAA-phenylalanine -> indole-3-acetic acid + phenylalanine." [GOC:syr]
is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity

[Term]
id: GO:0010211
name: IAA-Leu conjugate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: IAA-leucine -> indole-3-acetic acid + leucine." [GOC:syr]
xref: MetaCyc:RXN-2982
is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity

[Term]
id: GO:0010212
name: response to ionizing radiation
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526]
synonym: "response to ionising radiation" EXACT []
synonym: "response to ionizing radiation stimulus" EXACT []
is_a: GO:0009314 ! response to radiation

[Term]
id: GO:0010213
name: non-photoreactive DNA repair
namespace: biological_process
def: "A DNA repair process that is involved in repairing UV-induced DNA damage under non-photoreactivating conditions. The mechanism by which this repair process operates has not yet been completely elucidated." [GOC:syr]
subset: gosubset_prok
synonym: "light-independent DNA repair" EXACT [GOC:syr]
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0010214
name: seed coat development
namespace: biological_process
def: "The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0010215
name: cellulose microfibril organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellulose microfibril, any of the cellulose structures laid down in orthogonal layers in a plant cell wall." [GOC:mah, PMID:12468730]
synonym: "cellulose microfibril organisation" EXACT [GOC:curators]
is_a: GO:0030198 ! extracellular matrix organization
relationship: part_of GO:0071668 ! plant-type cell wall assembly

[Term]
id: GO:0010216
name: maintenance of DNA methylation
namespace: biological_process
def: "Any process involved in maintaining the methylation state of a nucleotide sequence." [PMID:11898023]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006306 ! DNA methylation

[Term]
id: GO:0010217
name: cellular aluminum ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of aluminum ions at the level of a cell." [GOC:lr, GOC:mah]
synonym: "cellular aluminium ion homeostasis" EXACT [GOC:mah]
is_a: GO:0006875 ! cellular metal ion homeostasis
is_a: GO:0055079 ! aluminum ion homeostasis

[Term]
id: GO:0010218
name: response to far red light
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:tb]
synonym: "response to far red light stimulus" EXACT []
is_a: GO:0009639 ! response to red or far red light

[Term]
id: GO:0010219
name: regulation of vernalization response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm]
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:0010048 ! vernalization response

[Term]
id: GO:0010220
name: positive regulation of vernalization response
namespace: biological_process
def: "Any process that activates or induces the rate of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm]
synonym: "activation of vernalization response" NARROW []
synonym: "stimulation of vernalization response" NARROW []
synonym: "up regulation of vernalization response" EXACT []
synonym: "up-regulation of vernalization response" EXACT []
synonym: "upregulation of vernalization response" EXACT []
is_a: GO:0010219 ! regulation of vernalization response
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0010048 ! vernalization response

[Term]
id: GO:0010221
name: negative regulation of vernalization response
namespace: biological_process
def: "Any process that stops, prevents or reduces the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm]
synonym: "down regulation of vernalization response" EXACT []
synonym: "down-regulation of vernalization response" EXACT []
synonym: "downregulation of vernalization response" EXACT []
synonym: "inhibition of vernalization response" NARROW []
is_a: GO:0010219 ! regulation of vernalization response
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0010048 ! vernalization response

[Term]
id: GO:0010222
name: stem vascular tissue pattern formation
namespace: biological_process
def: "Vascular tissue pattern formation as it occurs in the stem of vascular plants." [GOC:tb]
is_a: GO:0010051 ! xylem and phloem pattern formation

[Term]
id: GO:0010223
name: secondary shoot formation
namespace: biological_process
def: "The process that gives rise to secondary (or auxiliary or axillary) shoots in plants. This process pertains to the initial formation of a structure from unspecified parts. These secondary shoots originate from secondary meristems initiated in the axils of leaf primordia. Axillary meristems function like the shoot apical meristem of the primary shoot initating the development of lateral organs." [GOC:tb, PMID:12815068]
synonym: "auxiliary shoot formation" EXACT []
synonym: "axillary shoot formation" EXACT []
is_a: GO:0010346 ! shoot formation

[Term]
id: GO:0010224
name: response to UV-B
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 290 to 320 nm." [GOC:tb]
synonym: "response to medium wave ultraviolet light stimulus" EXACT []
synonym: "response to medium wave ultraviolet radiation stimulus" EXACT []
synonym: "response to UV-B light stimulus" EXACT []
synonym: "response to UV-B radiation stimulus" EXACT []
synonym: "response to UVB light stimulus" EXACT []
synonym: "response to UVB radiation stimulus" EXACT []
is_a: GO:0009411 ! response to UV

[Term]
id: GO:0010225
name: response to UV-C
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 290 nm." [GOC:tb]
synonym: "response to germicidal ultraviolet light stimulus" EXACT []
synonym: "response to germicidal ultraviolet radiation stimulus" EXACT []
synonym: "response to shortwave ultraviolet light stimulus" EXACT []
synonym: "response to shortwave ultraviolet radiation stimulus" EXACT []
synonym: "response to UV-C light stimulus" EXACT []
synonym: "response to UV-C radiation stimulus" EXACT []
synonym: "response to UVC light stimulus" EXACT []
synonym: "response to UVC radiation stimulus" EXACT []
is_a: GO:0009411 ! response to UV

[Term]
id: GO:0010226
name: response to lithium ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:tb]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010227
name: floral organ abscission
namespace: biological_process
def: "The controlled shedding of floral organs." [PMID:12972671]
is_a: GO:0009838 ! abscission
relationship: part_of GO:0048437 ! floral organ development

[Term]
id: GO:0010228
name: vegetative to reproductive phase transition of meristem
namespace: biological_process
def: "The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence." [GOC:tb]
synonym: "floral evocation" RELATED [DOI:10.1146/annurev.pp.39.060188.001135]
synonym: "flowering" RELATED []
synonym: "transition from vegetative to reproductive phase" EXACT []
is_a: GO:0003006 ! reproductive developmental process
relationship: part_of GO:0009791 ! post-embryonic development
relationship: part_of GO:0048608 ! reproductive structure development

[Term]
id: GO:0010229
name: inflorescence development
namespace: biological_process
def: "The process whose specific outcome is the progression of an inflorescence over time, from its formation to the mature structure." [GOC:tb]
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0010230
name: alternative respiration
namespace: biological_process
def: "Alternative respiration pathway consumes oxygen, oxidizes NADH to NAD+ and generates water. During electron flow, proton motive force is diminished resulting in fewer molecules of ATP compared to cytochrome pathway. The pathway is found in plants, algae and some protozoa." [ISBN:0943088399]
is_a: GO:0045333 ! cellular respiration

[Term]
id: GO:0010231
name: maintenance of seed dormancy
namespace: biological_process
def: "Any process by which a dormant state is maintained in a seed." [PMID:9580097]
is_a: GO:0009737 ! response to abscisic acid stimulus
is_a: GO:0022611 ! dormancy process
relationship: part_of GO:0010162 ! seed dormancy

[Term]
id: GO:0010232
name: vascular transport
namespace: biological_process
def: "The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane." [GOC:sm]
is_a: GO:0006810 ! transport
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0010233
name: phloem transport
namespace: biological_process
def: "The directed movement of substances, into, out of or within a cell, either in a phloem tissue or in the phloem membrane." [GOC:sm]
is_a: GO:0010232 ! vascular transport

[Term]
id: GO:0010234
name: tapetal cell fate specification
namespace: biological_process
def: "The process by which a cell becomes capable of differentiating autonomously into a tapetal cell of anthers in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0048657 ! tapetal cell differentiation

[Term]
id: GO:0010235
name: guard mother cell cytokinesis
namespace: biological_process
def: "The stereotyped symmetric cell division by which guard mother cell give rise to stomatal guard cells." [GOC:tb]
synonym: "guard mother cell division" EXACT []
is_a: GO:0000911 ! cytokinesis by cell plate formation
relationship: part_of GO:0010440 ! stomatal lineage progression

[Term]
id: GO:0010236
name: plastoquinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of plastoquinone, a lipid-soluble electron-transporting coenzyme present in the chloroplast." [GOC:sm]
synonym: "plastoquinone anabolism" EXACT []
synonym: "plastoquinone biosynthesis" EXACT []
synonym: "plastoquinone formation" EXACT []
synonym: "plastoquinone synthesis" EXACT []
xref: MetaCyc:PWY-1581
is_a: GO:0045426 ! quinone cofactor biosynthetic process

[Term]
id: GO:0010238
name: response to proline
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus." [GOC:sm]
is_a: GO:0043200 ! response to amino acid stimulus

[Term]
id: GO:0010239
name: chloroplast mRNA processing
namespace: biological_process
def: "Steps involved in processing precursor RNAs arising from transcription of operons in the chloroplast genome into mature mRNAs." [GOC:tb, PMID:9648738]
is_a: GO:0006397 ! mRNA processing
is_a: GO:0031425 ! chloroplast RNA processing

[Term]
id: GO:0010240
name: plastid pyruvate dehydrogenase complex
namespace: cellular_component
def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). This complex is found in plant plastids and is distinct from the one found in mitochondria." [GOC:mtg_sensu, PMID:9393637]
synonym: "dehydrogenase complex" BROAD []
is_a: GO:0044435 ! plastid part
is_a: GO:0045254 ! pyruvate dehydrogenase complex

[Term]
id: GO:0010241
name: ent-kaurene oxidase activity
namespace: molecular_function
def: "Catalysis of three successive oxidations of the 4-methyl group of ent-kaurene resulting in kaurenoic acid." [GOC:tb]
synonym: "ent-kaur-16-ene,NADPH:oxygen oxidoreductase (hydroxylating) activity" EXACT []
xref: EC:1.14.13.78
xref: MetaCyc:1.14.13.78-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0010242
name: oxygen evolving activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:kd, GOC:syr, PMID:17091926, PMID:7948862]
synonym: "photosynthetic water oxidation" EXACT []
xref: MetaCyc:PSII-RXN
xref: MetaCyc:RXN0-5265
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0010243
name: response to organic nitrogen
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic nitrogen stimulus. An organic nitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [ChEBI:35352, PMID:9869419]
synonym: "response to organonitrogen compound" EXACT [ChEBI:35352]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0010244
name: response to low fluence blue light stimulus by blue low-fluence system
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a low fluence blue light stimulus by the blue low-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue low-fluence system responds to blue light at or below 0.1 micromols/m2. In certain species excitation of the blue low fluence system induces the transcription of a number of nuclear and plastid coded genes." [GOC:mtg_far_red, PMID:10398709]
synonym: "response to low fluence blue light" BROAD []
synonym: "response to low fluence blue light by blf system" EXACT []
is_a: GO:0009637 ! response to blue light
is_a: GO:0009645 ! response to low light intensity stimulus

[Term]
id: GO:0010245
name: radial microtubular system formation
namespace: biological_process
def: "Formation of radial microtubular systems during male meiotic cytokinesis in plants." [GOC:syr]
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0010246
name: rhamnogalacturonan I biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan I component of pectin, a rhamnose-rich pectic polysaccharide." [GOC:pz]
synonym: "rhamnogalacturonan I anabolism" EXACT []
synonym: "rhamnogalacturonan I biosynthesis" EXACT []
synonym: "rhamnogalacturonan I formation" EXACT []
synonym: "rhamnogalacturonan I synthesis" EXACT []
is_a: GO:0045489 ! pectin biosynthetic process

[Term]
id: GO:0010247
name: detection of phosphate ion
namespace: biological_process
def: "The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal." [GOC:sm]
synonym: "phosphate ion detection" EXACT []
synonym: "phosphate ion perception" RELATED []
synonym: "phosphate ion sensing" RELATED []
is_a: GO:0009593 ! detection of chemical stimulus

[Term]
id: GO:0010248
name: establishment or maintenance of transmembrane electrochemical gradient
namespace: biological_process
def: "The directed movement of ions to establish or maintain an electrochemical gradient across a membrane." [GOC:mah, GOC:sm]
is_a: GO:0006810 ! transport

[Term]
id: GO:0010249
name: auxin conjugate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving auxin conjugates, a bound form of auxin." [GOC:sm]
synonym: "auxin conjugate metabolism" EXACT []
is_a: GO:0009850 ! auxin metabolic process

[Term]
id: GO:0010250
name: S-methylmethionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of S-methyl-methionine (SMM) from methionine and S-adenosyl-methionine (Ado-Met), catalyzed by methionine S-methyltransferase (MMT). SMM can be reconverted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle." [PMID:12692340]
synonym: "S-methylmethionine anabolism" EXACT []
synonym: "S-methylmethionine biosynthesis" EXACT []
synonym: "S-methylmethionine formation" EXACT []
synonym: "S-methylmethionine synthesis" EXACT []
is_a: GO:0033477 ! S-methylmethionine metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0010252
name: auxin homeostasis
namespace: biological_process
def: "Maintenance of endogenous concentration of primary auxin equilibrium, or constant level of auxin in a biological system by a number of biochemical processes including transport, biosynthesis, catabolism and conjugation." [http://diss-epsilon.slu.se/archive/00000215/]
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0010253
name: UDP-rhamnose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate." [PMID:15134748]
synonym: "UDP-rhamnose anabolism" EXACT []
synonym: "UDP-rhamnose biosynthesis" EXACT []
synonym: "UDP-rhamnose formation" EXACT []
synonym: "UDP-rhamnose synthesis" EXACT []
xref: MetaCyc:PWY-3261
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0019300 ! rhamnose biosynthetic process
is_a: GO:0033478 ! UDP-rhamnose metabolic process

[Term]
id: GO:0010254
name: nectary development
namespace: biological_process
def: "The process whose specific outcome is the progression of the floral nectaries over time, from its formation to the mature structure." [GOC:lr]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0010255
name: glucose mediated signaling pathway
namespace: biological_process
def: "The process by which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes." [GOC:sm]
synonym: "glucose mediated signalling" EXACT []
is_a: GO:0009757 ! hexose mediated signaling
is_a: GO:0071333 ! cellular response to glucose stimulus

[Term]
id: GO:0010256
name: endomembrane organization
namespace: biological_process
def: "The assembly and arrangement of endomembrane systems." [GOC:sm]
synonym: "endomembrane system organization" EXACT []
is_a: GO:0016044 ! cellular membrane organization

[Term]
id: GO:0010257
name: NADH dehydrogenase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex." [GOC:sm]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0010258
name: NADH dehydrogenase complex (plastoquinone) assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I." [PMID:15608332]
is_a: GO:0010257 ! NADH dehydrogenase complex assembly

[Term]
id: GO:0010259
name: multicellular organismal aging
namespace: biological_process
def: "The inherent decline of a multicellular organism over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu, GOC:sm]
is_a: GO:0007568 ! aging
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0010260
name: organ senescence
namespace: biological_process
alt_id: GO:0010261
def: "The process that occurs in an organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:sm]
is_a: GO:0010149 ! senescence
relationship: part_of GO:0048513 ! organ development

[Term]
id: GO:0010262
name: somatic embryogenesis
namespace: biological_process
def: "Initiation of a somatic embryo-an embryo arising from previously differentiated somatic cells, rather than from fused haploid gametes." [GOC:sm, PMID:9611173]
is_a: GO:0009793 ! embryonic development ending in seed dormancy

[Term]
id: GO:0010263
name: tricyclic triterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tricyclic triterpenoid compounds, terpenoids with 6 isoprene units and 3 carbon rings." [GOC:ct]
synonym: "tricyclic triterpenoid anabolism" EXACT [GOC:tair_curators]
synonym: "tricyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators]
synonym: "tricyclic triterpenoid formation" EXACT [GOC:tair_curators]
synonym: "tricyclic triterpenoid synthesis" EXACT [GOC:tair_curators]
is_a: GO:0010683 ! tricyclic triterpenoid metabolic process
is_a: GO:0016104 ! triterpenoid biosynthetic process

[Term]
id: GO:0010264
name: myo-inositol hexakisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds." [ChEBI:17401, PMID:16107538]
synonym: "myo-inositol hexakisphosphate anabolism" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthesis" EXACT []
synonym: "myo-inositol hexakisphosphate formation" EXACT []
synonym: "myo-inositol hexakisphosphate synthesis" EXACT []
synonym: "phytate biosynthesis" EXACT []
synonym: "phytate biosynthetic process" EXACT []
is_a: GO:0032958 ! inositol phosphate biosynthetic process
is_a: GO:0033517 ! myo-inositol hexakisphosphate metabolic process

[Term]
id: GO:0010265
name: SCF complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex." [GOC:pz]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0010266
name: response to vitamin B1
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:pz]
synonym: "response to thiamin" EXACT []
synonym: "response to thiamine" EXACT []
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0010267
name: production of ta-siRNAs involved in RNA interference
namespace: biological_process
def: "Cleavage of double-stranded RNA to form trans-acting small interfering RNA molecules (siRNAs) of 21-23 nucleotides. ta-siRNAs arise from PolII genes and function like miRNAs to guide cleavage of target mRNAs." [GOC:tb, PMID:16129836]
synonym: "RNA interference, production of ta-siRNAs" EXACT [GOC:mah]
is_a: GO:0030422 ! production of siRNA involved in RNA interference

[Term]
id: GO:0010268
name: brassinosteroid homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of brassinosteroids within an organism or cell." [PMID:15908602]
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0010269
name: response to selenium ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion." [GOC:mg]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010270
name: photosystem II oxygen evolving complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the oxygen evolving complex (OEC) of photosystem II on thylakoid membrane. In plants, the photosystem II OEC consists of three extrinsic nuclear-encoded polypeptides: PsbO, PsbP and PsbQ; and protects the CaMn4 cluster bound to D1 and CP43 proteins." [PMID:16282331]
synonym: "OEC (PSII) ASSEMBLY" EXACT [PMID:16282331]
is_a: GO:0010207 ! photosystem II assembly

[Term]
id: GO:0010271
name: regulation of chlorophyll catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of chlorophyll." [PMID:16361392]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0090056 ! regulation of chlorophyll metabolic process
relationship: regulates GO:0015996 ! chlorophyll catabolic process

[Term]
id: GO:0010272
name: response to silver ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus." [PMID:16367966]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010273
name: detoxification of copper ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion." [PMID:16367966]
is_a: GO:0009636 ! response to toxin
is_a: GO:0046688 ! response to copper ion

[Term]
id: GO:0010274
name: hydrotropism
namespace: biological_process
def: "Growth or movement in a sessile organism toward or away from water, as of the roots of a plant." [ISBN:0395825172]
xref: Wikipedia:Hydrotropism
is_a: GO:0009606 ! tropism

[Term]
id: GO:0010275
name: NAD(P)H dehydrogenase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form NAD(P)H dehydrogenase complex, which is involved in electron transport from an unidentified electron donor, possibly NAD(P)H or ferredoxin(Fd) to the plastoquinone pool." [GOC:sm]
synonym: "NAD(P)H dehydrogenase complex (plastoquinone) assembly" NARROW []
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0010276
name: phytol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: phytol + CTP = phytylphosphate + CDP." [PMID:16361393]
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0010277
name: chlorophyllide a oxygenase activity
namespace: molecular_function
alt_id: GO:0046407
def: "Catalysis of hydroxylation at the 7-methyl group of chlorophyllide a, according to the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+ and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+." [EC:1.13.12.14, MetaCyc:RXN-7677]
synonym: "CAO" RELATED [EC:1.13.12.14]
synonym: "chlorophyll a oxygenase activity" EXACT []
synonym: "chlorophyll b synthetase activity" EXACT []
synonym: "chlorophyll-b synthase activity" EXACT [EC:1.13.12.14]
synonym: "chlorophyllide a:oxygen 7-oxidoreductase activity" EXACT [EC:1.13.12.14]
synonym: "chlorophyllide-a oxygenase activity" EXACT [EC:1.13.12.14]
xref: EC:1.13.12.14
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0010278
name: chloroplast outer membrane translocon
namespace: cellular_component
def: "The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner." [PMID:11299338]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009707 ! chloroplast outer membrane

[Term]
id: GO:0010279
name: indole-3-acetic acid amido synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction IAA + an amino acid = an IAA amide conjugate." [PMID:15659623]
subset: gosubset_prok
synonym: "IAA amido synthetase activity" EXACT []
synonym: "IAA amino acid conjugate synthetase activity" EXACT [GOC:kad]
synonym: "IAA amino acid synthetase activity" EXACT [GOC:kad]
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0010280
name: UDP-L-rhamnose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction UDP-D-glucose + NADPH = UDP-L-rhamnose + NADP+ + H2O." [GOC:tair_curators, PMID:14701918]
synonym: "UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity" NARROW [GOC:tb]
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0010282
name: senescence associated vacuole
namespace: cellular_component
def: "A lytic vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast." [PMID:15743448]
is_a: GO:0000323 ! lytic vacuole
is_a: GO:0000325 ! plant-type vacuole

[Term]
id: GO:0010283
name: pinoresinol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: pinoresinol + NADPH = lariciresinol + NADP+." [PMID:10066819, PMID:7592828]
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0010284
name: lariciresinol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: lariciresinol + NADPH = secoisolariciresinol + NADP+." [PMID:10066819, PMID:7592828]
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0010285
name: L,L-diaminopimelate aminotransferase activity
namespace: molecular_function
alt_id: GO:0043742
def: "Catalysis of the reaction: LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O." [PMID:16361515]
synonym: "LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT []
synonym: "LL-DAP aminotransferase activity" EXACT [EC:2.6.1.83]
synonym: "LL-DAP-AT activity" EXACT [EC:2.6.1.83]
synonym: "LL-diaminopimelate aminotransferase activity" EXACT []
synonym: "LL-diaminopimelate transaminase activity" EXACT [EC:2.6.1.83]
xref: EC:2.6.1.83
xref: MetaCyc:2.6.1.83-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0010286
name: heat acclimation
namespace: biological_process
def: "Any process that increases heat tolerance of an organism in response to high temperatures." [GOC:tair_curators]
is_a: GO:0009408 ! response to heat

[Term]
id: GO:0010287
name: plastoglobule
namespace: cellular_component
def: "Plastoglobules (PG) are lipoprotein particles present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." [GOC:tair_curators, PMID:16461379]
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0010288
name: response to lead ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus." [GOC:tair_curators, PMID:16461380]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0010289
name: homogalacturonan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the pectidic homogalacturonan, characterized by a backbone of 1,4-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [PMID:12913136, PMID:16540543]
xref: MetaCyc:PWY-1061
is_a: GO:0045489 ! pectin biosynthetic process

[Term]
id: GO:0010290
name: chlorophyll catabolite transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), from one side of the membrane to the other." [PMID:9681016]
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0010291
name: carotene beta-ring hydroxylase activity
namespace: molecular_function
alt_id: GO:0042411
def: "Catalysis of C3-hydroxylation of the beta-ring of various carotenes." [MetaCyc:MONOMER-12386, PMID:16492736]
synonym: "beta-carotene hydroxylase activity" NARROW []
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0010292
name: GTP:GDP antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out)." [PMID:10514379, PMID:12553910, PMID:16553903]
is_a: GO:0015300 ! solute:solute antiporter activity

[Term]
id: GO:0010293
name: abscisic aldehyde oxidase activity
namespace: molecular_function
alt_id: GO:0033725
def: "Catalysis of the reaction: abscisic aldehyde + H2O + O2 = abscisate + H2O2." [EC:1.2.3.14, PMID:11050171]
synonym: "AAO3" RELATED [EC:1.2.3.14]
synonym: "abscisic-aldehyde oxidase activity" EXACT [EC:1.2.3.14]
synonym: "abscisic-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.14]
synonym: "AOdelta" RELATED [EC:1.2.3.14]
xref: EC:1.2.3.14
xref: MetaCyc:1.2.3.14-RXN
is_a: GO:0018488 ! aryl-aldehyde oxidase activity

[Term]
id: GO:0010294
name: abscisic acid glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ABA + UDP-D-glucose = ABA-glucose ester + UDP." [DOI:10.1016/j.tetasy.2004.11.062]
xref: MetaCyc:PWY-5272
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0010295
name: (+)-abscisic acid 8'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-abscisate + NADPH + H+ + O2 = 8'-hydroxyabscisate + NADP+ + H2O." [EC:1.14.13.93]
synonym: "(+)-ABA 8'-hydroxylase activity" EXACT [EC:1.14.13.93]
synonym: "ABA 8'-hydroxylase activity" EXACT [EC:1.14.13.93]
synonym: "ABA 8'-Hydroxylase activity, Abscisate 8'-hydroxylase activity" RELATED []
synonym: "abscisate,NADPH:oxygen oxidoreductase (8'-hydroxylating)" EXACT [EC:1.14.13.93]
synonym: "abscisic acid 8'-hydroxylase activity" EXACT []
xref: EC:1.14.13.93
xref: MetaCyc:1.14.13.93-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0010296
name: prenylcysteine methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein prenyl L-cysteine methylester + H2O = protein L-cysteine + methanol." [PMID:16870359]
is_a: GO:0051723 ! protein methylesterase activity

[Term]
id: GO:0010297
name: heteroglycan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with heteroglycans." [PMID:16640603]
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0010298
name: dihydrocamalexic acid decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2." [PMID:16766671]
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0010299
name: detoxification of cobalt ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of cobalt ion. These include transport of cobalt away from sensitive areas and to compartments or complexes whose purpose is sequestration of cobalt ion." [GOC:tair_curators]
is_a: GO:0009636 ! response to toxin

[Term]
id: GO:0010301
name: xanthoxin dehydrogenase activity
namespace: molecular_function
alt_id: GO:0033710
def: "Catalysis of the reaction: xanthoxin + NAD+ = abscisic aldehyde + NADH + H+." [EC:1.1.1.288, PMID:12172025]
synonym: "ABA2" RELATED [EC:1.1.1.288]
synonym: "xanthoxin oxidase activity" EXACT [EC:1.1.1.288]
synonym: "xanthoxin:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.288]
xref: EC:1.1.1.288
xref: MetaCyc:1.1.1.288-RXN
is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity

[Term]
id: GO:0010302
name: 2-oxoglutarate-dependent dioxygenase activity
namespace: molecular_function
def: "Hydroxylase, with 2-oxoglutarate as one donor, and incorporation or reduction of one atom each of oxygen into both donors." [EC:1.14.11.-, PMID:16140259]
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0010303
name: limit dextrinase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (16)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan." [EC:3.2.1.142]
synonym: "amylopectin-1,6-glucosidase activity" EXACT [EC:3.2.1.142]
synonym: "dextrin alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.142]
synonym: "R-enzyme" RELATED [EC:3.2.1.142]
xref: EC:3.2.1.142
xref: MetaCyc:3.2.1.10-RXN
xref: MetaCyc:3.2.1.142-RXN
xref: MetaCyc:RXN-1824
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0010304
name: PSII associated light-harvesting complex II catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II." [GOC:mah, PMID:16157880]
synonym: "LHCII catabolism" RELATED []
is_a: GO:0044257 ! cellular protein catabolic process

[Term]
id: GO:0010305
name: leaf vascular tissue pattern formation
namespace: biological_process
def: "Vascular tissue pattern formation as it occurs in the leaf of vascular plants." [GOC:tair_curators]
is_a: GO:0010051 ! xylem and phloem pattern formation

[Term]
id: GO:0010306
name: rhamnogalacturonan II biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan II, a low molecular mass (5 - 10KDa) pectic polysaccharide, conserved in the primary walls of dicotyledenous and monocotyledenous plants and gymnosperms." [PMID:12754267]
is_a: GO:0045489 ! pectin biosynthetic process

[Term]
id: GO:0010307
name: acetylglutamate kinase regulator activity
namespace: molecular_function
def: "Modulates the enzyme activity of acetylglutamate kinase." [PMID:16377628]
is_a: GO:0019207 ! kinase regulator activity

[Term]
id: GO:0010308
name: acireductone dioxygenase (Ni2+-requiring) activity
namespace: molecular_function
def: "Catalysis of reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 3-(methylthio)propanoate + formate + CO." [EC:1.13.11.53, PMID:16297065]
synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)" EXACT [EC:1.13.11.53]
synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase activity" BROAD [EC:1.13.11.53]
synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.53]
synonym: "ARD activity" RELATED [EC:1.13.11.53]
synonym: "E-2 activity" RELATED [EC:1.13.11.53]
xref: EC:1.13.11.53
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0010309
name: acireductone dioxygenase [iron(II)-requiring] activity
namespace: molecular_function
def: "Catalysis of reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-(methylthio)-2-oxobutanoate + formate." [EC:1.13.11.54, PMID:16297065]
subset: gosubset_prok
synonym: "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase activity" EXACT []
synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)" EXACT [EC:1.13.11.54]
synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase" BROAD []
synonym: "aci-reductone dioxygenase" BROAD []
synonym: "acireductone dioxygenase (Fe2+-requiring) activity" EXACT []
synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.54]
synonym: "ARD'" RELATED []
synonym: "ARD1" RELATED []
synonym: "E-2'" RELATED []
xref: EC:1.13.11.54
xref: MetaCyc:R147-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0010310
name: regulation of hydrogen peroxide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [PMID:14765119]
synonym: "regulation of hydrogen peroxide metabolism" EXACT []
is_a: GO:0080010 ! regulation of oxygen and reactive oxygen species metabolic process
relationship: regulates GO:0042743 ! hydrogen peroxide metabolic process

[Term]
id: GO:0010311
name: lateral root formation
namespace: biological_process
def: "The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tair_curators]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010102 ! lateral root morphogenesis

[Term]
id: GO:0010312
name: detoxification of zinc ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion." [GOC:tair_curators]
is_a: GO:0009636 ! response to toxin
is_a: GO:0010043 ! response to zinc ion

[Term]
id: GO:0010313
name: phytochrome binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phytochrome." [PMID:15486102]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0010314
name: phosphatidylinositol-5-phosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a phosphorylated derivative of phosphatidylinositol." [GOC:tair_curators]
is_a: GO:0035091 ! phosphoinositide binding

[Term]
id: GO:0010315
name: auxin efflux
namespace: biological_process
def: "The process involved in the transport of auxin out of the cell." [GOC:tair_curators]
synonym: "auxin export" EXACT []
is_a: GO:0060918 ! auxin transport
relationship: part_of GO:0009734 ! auxin mediated signaling pathway

[Term]
id: GO:0010316
name: pyrophosphate-dependent phosphofructokinase complex
namespace: cellular_component
def: "Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate." [PMID:2170409]
subset: goslim_pir
synonym: "PFK complex" RELATED []
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0010317
name: pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex
namespace: cellular_component
def: "Refers to the alpha subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409]
synonym: "PFK complex, alpha-subunit" RELATED []
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex

[Term]
id: GO:0010318
name: pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex
namespace: cellular_component
def: "Refers to the beta subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409]
synonym: "PFK complex, beta-subunit" RELATED []
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex

[Term]
id: GO:0010319
name: stromule
namespace: cellular_component
def: "Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types." [PMID:15272881, PMID:15699062, PMID:16582010]
synonym: "Stroma-filled tubule" RELATED []
xref: Wikipedia:Stromule
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009526 ! plastid envelope

[Term]
id: GO:0010320
name: arginine/lysine endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which arginine or lysine residues act as nucleophiles." [GOC:tair_curators]
comment: This term was made obsolete because it was defined incorrectly: there are no known peptidases using a catalytic mechanism involving arginine and lysine, and the Arabidopsis metacaspases that prompted addition of this term are in fact cysteine-type endopeptidases.
is_obsolete: true
replaced_by: GO:0004175
replaced_by: GO:0004197

[Term]
id: GO:0010321
name: regulation of vegetative phase change
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vegetative phase change. Vegetative phase change is the set of post-embryonic processes involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tair_curators]
is_a: GO:0048580 ! regulation of post-embryonic development
relationship: regulates GO:0010050 ! vegetative phase change

[Term]
id: GO:0010322
name: regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
relationship: regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway

[Term]
id: GO:0010323
name: negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478]
synonym: "down regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT []
synonym: "down-regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT []
synonym: "downregulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT []
synonym: "inhibition of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" NARROW []
is_a: GO:0010322 ! regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process
relationship: negatively_regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway

[Term]
id: GO:0010324
name: membrane invagination
namespace: biological_process
def: "The infolding of a membrane, resulting in formation of a vesicle." [GOC:tb]
is_a: GO:0016044 ! cellular membrane organization

[Term]
id: GO:0010325
name: raffinose family oligosaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of raffinose family oligosaccharides (RFOs, such as raffinose, stachyose, verbascose and other molecules with a higher degree of galactosyl polymerization)." [GOC:tair_curators]
synonym: "raffinose family oligosaccharide biosynthesis" EXACT []
is_a: GO:0009312 ! oligosaccharide biosynthetic process

[Term]
id: GO:0010326
name: methionine-oxo-acid transaminase activity
namespace: molecular_function
def: "Catalyzes the reaction: methionine + a 2-oxo acid = 4-methylthio-2-oxobutyrate + an amino acid." [PMID:17056707]
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0010327
name: acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity
namespace: molecular_function
def: "Catalyzes the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate." [PMID:17163883]
synonym: "hexenol acetyltransferase" RELATED []
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0010328
name: auxin influx transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of auxin, from one side of a membrane to the other, into a cell." [PMID:16839804]
synonym: "auxin influx facilitator" RELATED []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0010329
name: auxin efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of auxin, from one side of a membrane to the other, out of a cell." [PMID:16839804]
synonym: "auxin efflux carrier" RELATED []
synonym: "auxin efflux facilitator" RELATED []
is_a: GO:0015562 ! efflux transmembrane transporter activity
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0010330
name: cellulose synthase complex
namespace: cellular_component
def: "The multimeric protein complex, organized in a rosette, which catalyzes the biosynthesis of cellulose for the plant cell wall." [PMID:12514238]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0010331
name: gibberellin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with gibberellins, plant hormones that regulate aspects of plant growth." [GOC:tair_curators]
synonym: "gibberellic acid receptor" RELATED []
synonym: "gibberellin receptor" RELATED []
is_a: GO:0019840 ! isoprenoid binding
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0010332
name: response to gamma radiation
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators, Wikipedia:Gamma_ray]
synonym: "response to gamma ray" RELATED []
synonym: "response to gamma-ray photon" RELATED []
is_a: GO:0010212 ! response to ionizing radiation

[Term]
id: GO:0010333
name: terpene synthase activity
namespace: molecular_function
def: "Catalyzing the formation of cyclic terpenes through the cyclization of linear terpenes containing varying quantities of isoprene units (i.e. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP)." [EC:4.2.3., GOC:tair_curators]
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0010334
name: sesquiterpene synthase activity
namespace: molecular_function
def: "Catalyzing the formation of sesquiterpenes (terpene containing 15 carbons, i.e. three isoprene units) through the cyclization of trans,trans-farnesyl diphosphate (an allylic prenyl diphosphate intermediates of the terpene biosynthesis pathway)." [EC:4.2.3.-, GOC:tair_curators]
is_a: GO:0010333 ! terpene synthase activity

[Term]
id: GO:0010335
name: response to non-ionic osmotic stress
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:tair_curators]
is_a: GO:0006970 ! response to osmotic stress

[Term]
id: GO:0010336
name: gibberellic acid homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal equilibrium of gibberellic acid; may involve transport, biosynthesis, catabolism or conjugation." [PMID:17194763]
synonym: "gibberellin homeostasis" BROAD []
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0010337
name: regulation of salicylic acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving salicylic acid." [PMID:14765119]
synonym: "regulation of salicylic acid metabolism" RELATED []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
relationship: regulates GO:0009696 ! salicylic acid metabolic process

[Term]
id: GO:0010338
name: leaf formation
namespace: biological_process
def: "The process that gives rise to a leaf. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tair_curators]
is_a: GO:0048645 ! organ formation
relationship: part_of GO:0009965 ! leaf morphogenesis

[Term]
id: GO:0010339
name: external side of cell wall
namespace: cellular_component
def: "The side of the cell wall that is opposite to the side that faces the cell and its contents." [GOC:mtg_sensu, GOC:tb]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009986 ! cell surface

[Term]
id: GO:0010340
name: carboxyl-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester." [PMID:17220201]
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0010341
name: gibberellin carboxyl-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + GA = S-adenosyl-L-homocysteine + GA methyl ester." [PMID:17220201]
is_a: GO:0010340 ! carboxyl-O-methyltransferase activity

[Term]
id: GO:0010342
name: cellularization of endosperm
namespace: biological_process
def: "The separation of the multi-nucleate endosperm into individual cells. In many plant species, the endosperm that nurtures the embryo in the seed initially develops as a syncytium. This syncytial phase ends with simultaneous partitioning of the multi-nucleate cytoplasm into individual cells, a process referred to as cellularization." [PMID:12421698]
synonym: "endosperm cellularization" EXACT []
is_a: GO:0007349 ! cellularization

[Term]
id: GO:0010343
name: singlet oxygen-mediated programmed cell death
namespace: biological_process
def: "Programmed cell death induced by singlet oxygen. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [PMID:17075038]
synonym: "light-dependent programmed cell death" BROAD []
is_a: GO:0012501 ! programmed cell death

[Term]
id: GO:0010344
name: seed oilbody biogenesis
namespace: biological_process
def: "The cellular process by which an seed oilbody is synthesized, aggregates, and bonds together. Seed oilbodies are simple organelles comprising a matrix of triglyceride surrounded by a phospholipid monolayer embedded and covered with unique proteins called oleosins. Seed oilbodies supply the energy requirements for the growth of the seedling after germination." [GOC:jl, PMID:16877495]
synonym: "oleosome biogenesis" RELATED []
synonym: "seed oil body organization" EXACT []
synonym: "spherosome biogenesis" RELATED []
is_a: GO:0044085 ! cellular component biogenesis
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0010345
name: suberin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of suberin monomers and suberin polyesters. Suberin monomers are derived from fatty acids and trans-cinnamic acids. The monomers are then cross-linked with glycerols." [PMID:17259262]
xref: MetaCyc:PWY-1121
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0009699 ! phenylpropanoid biosynthetic process

[Term]
id: GO:0010346
name: shoot formation
namespace: biological_process
def: "The process that gives rise to a shoot. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010016 ! shoot morphogenesis

[Term]
id: GO:0010347
name: L-galactose-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate." [PMID:15550539, PMID:16595667]
xref: MetaCyc:RXNQT-4142
is_a: GO:0070456 ! galactose-1-phosphate phosphatase activity

[Term]
id: GO:0010348
name: lithium:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in)." [PMID:17270011]
synonym: "lithium:proton antiporter activity" EXACT [GOC:mah]
is_a: GO:0005451 ! monovalent cation:hydrogen antiporter activity

[Term]
id: GO:0010349
name: L-galactose dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+." [PMID:12047629]
synonym: "L-galactose 1-dehydrogenase activity" RELATED []
xref: MetaCyc:RXN-1884
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0010350
name: cellular response to magnesium starvation
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of magnesium." [PMID:17270009]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0010351
name: lithium ion transport
namespace: biological_process
def: "The directed movement of lithium ion into, out of, within or between cells by means of some external agent such as a transporter or pore." [PMID:17270011]
synonym: "lithium transport" EXACT []
is_a: GO:0015672 ! monovalent inorganic cation transport

[Term]
id: GO:0010352
name: lithium ion export
namespace: biological_process
def: "The directed movement of lithium ion out of a cell or organelle." [PMID:17270011]
synonym: "lithium export" EXACT []
synonym: "lithium ion efflux" RELATED []
is_a: GO:0010351 ! lithium ion transport

[Term]
id: GO:0010353
name: response to trehalose stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512]
is_a: GO:0034285 ! response to disaccharide stimulus

[Term]
id: GO:0010354
name: homogentisate prenyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid." [PMID:16989822]
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0010355
name: homogentisate farnesyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: homogentisic acid + farnesyl diphosphate -> 2-methyl-6-farnesylplastoquinol." [PMID:16989822]
is_a: GO:0010354 ! homogentisate prenyltransferase activity

[Term]
id: GO:0010356
name: homogentisate geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: homogentisic acid + geranylgeranyl diphosphate -> 2-methyl-6-geranylgeranylplastoquinol." [PMID:16989822]
is_a: GO:0010354 ! homogentisate prenyltransferase activity

[Term]
id: GO:0010357
name: homogentisate solanesyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: homogentisic acid + solanesyl diphosphate -> 2-methyl-6-solanesylplastoquinol." [PMID:16989822]
is_a: GO:0010354 ! homogentisate prenyltransferase activity

[Term]
id: GO:0010358
name: leaf shaping
namespace: biological_process
def: "The developmental process that pertains to the organization of a leaf in three-dimensional space once the structure has initially formed." [GOC:tb, PMID:16971475]
synonym: "leaf structural organization" RELATED []
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0009965 ! leaf morphogenesis

[Term]
id: GO:0010359
name: regulation of anion channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anion channel activity." [PMID:17319842]
subset: gosubset_prok
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:0044070 ! regulation of anion transport

[Term]
id: GO:0010360
name: negative regulation of anion channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842]
is_a: GO:0010359 ! regulation of anion channel activity
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity

[Term]
id: GO:0010361
name: regulation of anion channel activity by blue light
namespace: biological_process
def: "Any process by which the blue light modulates the frequency, rate or extent of anion channel activity." [GOC:dph, GOC:tb, PMID:17319842]
synonym: "regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010359 ! regulation of anion channel activity

[Term]
id: GO:0010362
name: negative regulation of anion channel activity by blue light
namespace: biological_process
def: "Any process by which the blue light stops, prevents or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842]
synonym: "inhibition by blue light of anion channel activity" NARROW []
synonym: "negative regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010360 ! negative regulation of anion channel activity
is_a: GO:0010361 ! regulation of anion channel activity by blue light

[Term]
id: GO:0010363
name: regulation of plant-type hypersensitive response
namespace: biological_process
def: "Any endogenous process that modulates the frequency, rate or extent of the plant hypersensitive response." [PMID:16255244]
comment: Note that term is to be used to annotate gene products in the plant. To annotate genes in a symbiont, consider the biological process term 'modulation by symbiont of host programmed cell death ; GO:0052040'.
synonym: "regulation of HR" EXACT []
synonym: "regulation of HR-PCD" EXACT []
synonym: "regulation of plant hypersensitive response" EXACT []
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0009626 ! plant-type hypersensitive response

[Term]
id: GO:0010364
name: regulation of ethylene biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of an ethylene biosynthetic process." [GOC:tair_curators]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process
relationship: regulates GO:0009693 ! ethylene biosynthetic process

[Term]
id: GO:0010365
name: positive regulation of ethylene biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators]
is_a: GO:0010364 ! regulation of ethylene biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process
relationship: positively_regulates GO:0009693 ! ethylene biosynthetic process

[Term]
id: GO:0010366
name: negative regulation of ethylene biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators]
is_a: GO:0010364 ! regulation of ethylene biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process
relationship: negatively_regulates GO:0009693 ! ethylene biosynthetic process

[Term]
id: GO:0010367
name: extracellular isoamylase complex
namespace: cellular_component
def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in animals are localized in the extracellular space." [GOC:tair_curators]
subset: gosubset_prok
is_a: GO:0043033 ! isoamylase complex
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0010368
name: chloroplast isoamylase complex
namespace: cellular_component
def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in plants are intracellular and probably chloroplast localized." [GOC:tair_curators]
subset: gosubset_prok
is_a: GO:0043033 ! isoamylase complex
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0010369
name: chromocenter
namespace: cellular_component
def: "A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure." [PMID:12384572, PMID:15053486, PMID:16831888]
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0010370
name: perinucleolar chromocenter
namespace: cellular_component
def: "A chromocenter adjacent to the nucleolus." [PMID:15805479]
is_a: GO:0010369 ! chromocenter

[Term]
id: GO:0010371
name: regulation of gibberellin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators]
synonym: "regulation of gibberellic acid biosynthetic process" NARROW []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043455 ! regulation of secondary metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: regulates GO:0009686 ! gibberellin biosynthetic process

[Term]
id: GO:0010372
name: positive regulation of gibberellin biosynthetic process
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators]
synonym: "positive regulation of gibberellic acid biosynthetic process " NARROW []
is_a: GO:0010371 ! regulation of gibberellin biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
relationship: positively_regulates GO:0009686 ! gibberellin biosynthetic process

[Term]
id: GO:0010373
name: negative regulation of gibberellin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators]
synonym: "negative regulation of gibberellic acid biosynthetic process" NARROW []
is_a: GO:0010371 ! regulation of gibberellin biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
relationship: negatively_regulates GO:0009686 ! gibberellin biosynthetic process

[Term]
id: GO:0010374
name: stomatal complex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stomatal complex over time from its formation to the mature structure. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259]
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0010375
name: stomatal complex patterning
namespace: biological_process
def: "The regionalization process of establishing the non-random spatial arrangement of stomatal complex on the surface of a leaf. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259]
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0010376
name: stomatal complex formation
namespace: biological_process
def: "The process that gives rise to the stomatal complex. This process pertains to the initial formation of a structure from unspecified parts. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010103 ! stomatal complex morphogenesis

[Term]
id: GO:0010377
name: guard cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a stomatal guard cell. Guard cells are located in the leaf epidermis and pairwise surround stomatal pores, which allow CO2 influx for photosynthetic carbon fixation and water loss via transpiration to the atmosphere." [PMID:17259259]
synonym: "stomatal cell fate commitment" RELATED []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0010052 ! guard cell differentiation

[Term]
id: GO:0010378
name: temperature compensation of the circadian clock
namespace: biological_process
def: "The process by which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms." [PMID:16617099]
subset: gosubset_prok
synonym: "regulation of the circadian clock by temperature" RELATED []
is_a: GO:0009266 ! response to temperature stimulus
is_a: GO:0042752 ! regulation of circadian rhythm

[Term]
id: GO:0010379
name: phaseic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phaseic acid (PA), a catabolite of the plant hormone abscisic acid (ABA)." [BioCyc:PWY-5271 "http://biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-5271&detail-level=3"]
xref: MetaCyc:PWY-5271
is_a: GO:0016106 ! sesquiterpenoid biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0010380
name: regulation of chlorophyll biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [PMID:17291312]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0090056 ! regulation of chlorophyll metabolic process
relationship: regulates GO:0015995 ! chlorophyll biosynthetic process

[Term]
id: GO:0010381
name: attachment of peroxisome to chloroplast
namespace: biological_process
def: "The process by which a peroxisome is transported to, and/or maintained in, a location adjacent to the chloroplast." [PMID:17215364]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0010382
name: cellular cell wall macromolecule metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving macromolecules forming, or destined to form, part of a cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis, occurring at the level of the cell." [GOC:mah, GOC:tair_curators]
subset: gosubset_prok
synonym: "cellular cell wall macromolecule metabolism" EXACT []
is_a: GO:0044036 ! cell wall macromolecule metabolic process
is_a: GO:0044260 ! cellular macromolecule metabolic process
is_a: GO:0070882 ! cellular cell wall organization or biogenesis

[Term]
id: GO:0010383
name: cell wall polysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cell wall polysaccharides." [GOC:tair_curators]
subset: gosubset_prok
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0044036 ! cell wall macromolecule metabolic process

[Term]
id: GO:0010384
name: cell wall proteoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cell wall peptidoglycan, a group of glycoproteins that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators]
synonym: "cell wall proteoglycan metabolism" EXACT []
is_a: GO:0006029 ! proteoglycan metabolic process
is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process

[Term]
id: GO:0010385
name: double-stranded methylated DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded methylated DNA. Cytosine methylation in DNA is an important mechanism for establishing stable heritable epigenetic marks." [PMID:17242155]
is_a: GO:0003690 ! double-stranded DNA binding

[Term]
id: GO:0010386
name: lateral root primordium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral root primordium over time, which initiates the formation to the mature structure. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper." [PMID:17259263]
is_a: GO:0048527 ! lateral root development

[Term]
id: GO:0010387
name: signalosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a signalosome." [PMID:17307927]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0010388
name: cullin deneddylation
namespace: biological_process
def: "The modification of cullins by removal of ubiquitin-like protein NEDD8 (RUB1)." [PMID:17307927]
is_a: GO:0000338 ! protein deneddylation

[Term]
id: GO:0010389
name: regulation of G2/M transition of mitotic cell cycle
namespace: biological_process
def: "Any process that modulates the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [PMID:17329565]
synonym: "regulation of mitotic entry" EXACT [GOC:vw]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0000086 ! G2/M transition of mitotic cell cycle

[Term]
id: GO:0010390
name: histone monoubiquitination
namespace: biological_process
def: "The modification of histones by addition of a single ubiquitin moiety." [PMID:17329563]
is_a: GO:0006513 ! protein monoubiquitination
is_a: GO:0016574 ! histone ubiquitination

[Term]
id: GO:0010391
name: glucomannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucomannan, a polysaccharide composed of D-glucose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-glucose as single side-units." [GOC:tair_curators]
synonym: "glucomannan metabolism" EXACT []
is_a: GO:0006080 ! substituted mannan metabolic process

[Term]
id: GO:0010392
name: galactoglucomannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactoglucomannan, a polysaccharide composed of D-glucose, D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) decorated with a mixture of D-glucose and D-galactose side-units." [GOC:tair_curators]
synonym: "galactoglucomannan metabolism" RELATED []
is_a: GO:0006080 ! substituted mannan metabolic process

[Term]
id: GO:0010393
name: galacturonan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galacturonan, a pectin polymer containing a backbone of alpha-(1->4)-linked D-galacturonic acid residues." [GOC:tair_curators]
synonym: "galacturonan metabolism" EXACT []
is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process
is_a: GO:0052546 ! cell wall pectin metabolic process

[Term]
id: GO:0010394
name: homogalacturonan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving homogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [GOC:tair_curators]
synonym: "homogalacturonan metabolism" EXACT []
is_a: GO:0010393 ! galacturonan metabolic process

[Term]
id: GO:0010395
name: rhamnogalacturonan I metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rhamnogalacturonan I (RGI), a branched pectin with a backbone of alternating alpha-(1->2)-linked rhamnose and alpha-(1->4)-linked D-galacturonic acid residues that carries neutral side-chains of predominantly beta-(1->4)-D-galactose and/or alpha-(1->5)-L-arabinose residues attached to the rhamnose residues of the RGI backbone." [GOC:tair_curators]
synonym: "RGI metabolism" RELATED []
synonym: "rhamnogalacturonan I metabolism" EXACT []
is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process
is_a: GO:0052546 ! cell wall pectin metabolic process

[Term]
id: GO:0010396
name: rhamnogalacturonan II metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rhamnogalacturonan II, a low molecular mass (5-10KDa) pectic polysaccharide. The backbone of RG-II contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators]
synonym: "rhamnogalacturonan II metabolism" EXACT []
is_a: GO:0010393 ! galacturonan metabolic process

[Term]
id: GO:0010397
name: apiogalacturonan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the pectic apiogalacturonan, characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted with apiose and apiobiose (D-apiofuranosyl-beta-(l->3)-D-apiose) side chains via O-2 or O-3 links." [GOC:tair_curators]
synonym: "apiogalacturonan metabolism" EXACT []
is_a: GO:0010393 ! galacturonan metabolic process

[Term]
id: GO:0010398
name: xylogalacturonan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted on C-3 with beta-D-xylopyranose residues." [GOC:tair_curators]
synonym: "xylogalacturonan metabolism" EXACT []
is_a: GO:0010393 ! galacturonan metabolic process

[Term]
id: GO:0010399
name: rhamnogalacturonan I backbone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the alternating alpha-(1->2)-linked rhamnose and alpha-(1->2)-linked B-galacturonic acid residues of the rhamnogalacturonan I backbone." [GOC:tair_curators]
synonym: "rhamnogalacturonan I backbone metabolism" EXACT []
is_a: GO:0010395 ! rhamnogalacturonan I metabolic process

[Term]
id: GO:0010400
name: rhamnogalacturonan I side chain metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the side chains of the pectin, rhamnogalacturonan I." [GOC:tair_curators]
synonym: "rhamnogalacturonan I side chain metabolism" EXACT []
is_a: GO:0010395 ! rhamnogalacturonan I metabolic process

[Term]
id: GO:0010401
name: pectic galactan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactan, a polymer of D-galactosyl units that can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators]
synonym: "pectic galactan metabolism" EXACT []
is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process

[Term]
id: GO:0010402
name: pectic arabinan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arabinan, a polymer with an alpha-(1->5)-linked -L-arabinofuranose (Araf) backbone that can be substituted with Araf-alpha-(1->2)-, Araf-alpha-(1->3)-, and/or Araf-alpha-(1->3)-Araf-alpha-(1->3)-side chains. Arabinan can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators]
synonym: "pectic arabinan metabolism" EXACT []
is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process
is_a: GO:0031221 ! arabinan metabolic process

[Term]
id: GO:0010403
name: pectic arabinogalactan I metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pectic arabinogalactan I, an alpha-(1->4)-linked D-galactopyranose backbone that is substituted with alpha-l-Araf residues via the O-3 of the D-galactose residues. Arabinogalactan I can be found as a side chain of rhamnogalacturonan I." [GOC:tair_curators]
synonym: "pectic arabinogalactan I metabolism" EXACT []
is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process

[Term]
id: GO:0010404
name: cell wall hydroxyproline-rich glycoprotein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cell wall hydroxyproline-rich glycoprotein that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators]
synonym: "cell wall hydroxyproline-rich glycoprotein metabolism" EXACT []
is_a: GO:0010384 ! cell wall proteoglycan metabolic process

[Term]
id: GO:0010405
name: arabinogalactan protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein of highly varying length and domain complexity. These are O-glycosylated at one or more hydroxyproline residues by arabinogalactan (AG) type II groups, which consist of (1->3)-beta-galactan and (1->6)-beta-linked galactan chains connected to each other by (1->3,1->6)-linked branch points, O-3 and O-6 positions substituted with terminal arabinosyl residues. Also, rhamnose, fucose, glucuronic and galacturonic acid can be present in the glycan structures." [GOC:tair_curators]
synonym: "arabinogalactan protein metabolism" EXACT []
is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process

[Term]
id: GO:0010406
name: classical arabinogalactan protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein containing Hyp, Ala, Ser, Thr and Gly as the major amino acid constituents, and the C-terminus is GPI anchored." [GOC:tair_curators]
synonym: "classical-arabinogalactan protein metabolism" EXACT []
is_a: GO:0010405 ! arabinogalactan protein metabolic process

[Term]
id: GO:0010407
name: non-classical arabinogalactan protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein where other amino acids besides Hyp, Ala, Ser, Thr and Gly can be present and grouped into regions, such as a Cys-rich or Asn-rich domains." [GOC:tair_curators]
synonym: "non-classical arabinogalactan protein metabolism" EXACT []
is_a: GO:0010405 ! arabinogalactan protein metabolic process

[Term]
id: GO:0010408
name: fasciclin-like arabinogalactan protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the cell wall arabinogalactan II glycoprotein variant which contains both an arabinogalactan protein (AGP) motif and a fasciclin domain." [GOC:tair_curators]
synonym: "fasciclin-like arabinogalactan protein metabolism" EXACT []
is_a: GO:0010405 ! arabinogalactan protein metabolic process

[Term]
id: GO:0010409
name: extensin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving extensins, a group of 60-90 kDNA hydroxyproline (Hyp)-rich glycoproteins whose polypeptide backbone consists of many repeats of structural Ser(Hyp)4-6 motifs, with heavily glycosylated 1-4 arabinose residues O-linked to contiguous stretches of Hyp residues, with most of the Ser residues being O-galactosylated." [GOC:tair_curators]
synonym: "extensin metabolism" EXACT []
is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process

[Term]
id: GO:0010410
name: hemicellulose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hemicelluloses, plant cell wall polysaccharides that have a backbone of 1,4-linked beta-D-pyranosyl residues in which O4 is in the equatorial orientation. Many different hemicelluloses usually occur intermixed with each molecular type representing different degrees of polymerization and contain many different sugar monomers, which can include glucose, xylose, mannose, galactose, and arabinose. Hemicelluloses also contain most of the D-pentose sugars and occasionally small amounts of L-sugars as well. Xylose is always the sugar monomer present in the largest amount, but mannuronic acid and galacturonic acid also tend to be present." [GOC:tair_curators]
subset: gosubset_prok
synonym: "hemicellulose metabolism" EXACT []
is_a: GO:0010383 ! cell wall polysaccharide metabolic process

[Term]
id: GO:0010411
name: xyloglucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xyloglucan, the cross-linking glycan composed of (1->4)-beta-D-glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants." [GOC:tair_curators]
synonym: "xyloglucan metabolism" EXACT []
is_a: GO:0006073 ! cellular glucan metabolic process
is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process
is_a: GO:0010410 ! hemicellulose metabolic process

[Term]
id: GO:0010412
name: mannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannan, a group of polysaccharides containing a backbone composed of a polymer of D-mannose units." [GOC:tair_curators]
subset: gosubset_prok
synonym: "mannan metabolism" EXACT []
is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process
is_a: GO:0010410 ! hemicellulose metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0010413
name: glucuronoxylan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid side units." [GOC:tair_curators]
synonym: "glucuronoxylan metabolism" EXACT []
is_a: GO:0045491 ! xylan metabolic process

[Term]
id: GO:0010414
name: glucuronoarabinoxylan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid and arabinose side units." [GOC:tair_curators]
synonym: "glucuronoarabinoxylan metabolism" EXACT []
is_a: GO:0010413 ! glucuronoxylan metabolic process
is_a: GO:0010416 ! arabinoxylan metabolic process

[Term]
id: GO:0010415
name: unsubstituted mannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the mannan backbone, the unsubstituted polymer of D-mannose units." [GOC:tair_curators]
synonym: "unsubstituted mannan metabolism" EXACT []
is_a: GO:0010412 ! mannan metabolic process

[Term]
id: GO:0010416
name: arabinoxylan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone decorated with arabinose side units." [GOC:tair_curators]
synonym: "arabinoxylan metabolism" EXACT []
is_a: GO:0045491 ! xylan metabolic process

[Term]
id: GO:0010417
name: glucuronoxylan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucuronoxylan, a polymer containing a beta-1,4-linked D-xylose backbone substituted with glucuronic acid residues." [GOC:tair_curators]
synonym: "glucuronoxylan anabolism" EXACT []
synonym: "glucuronoxylan biosynthesis" EXACT []
synonym: "glucuronoxylan formation" EXACT []
synonym: "glucuronoxylan synthesis" EXACT []
is_a: GO:0010413 ! glucuronoxylan metabolic process
is_a: GO:0045492 ! xylan biosynthetic process

[Term]
id: GO:0010418
name: rhamnogalacturonan II backbone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the backbone structure of pectic rhamnogalacturonan II. The back bone contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators]
synonym: "rhamnogalacturonan II backbone metabolism" EXACT []
is_a: GO:0010394 ! homogalacturonan metabolic process
is_a: GO:0010396 ! rhamnogalacturonan II metabolic process

[Term]
id: GO:0010419
name: rhamnogalacturonan II side chain metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the side chains of pectic rhamnogalacturonan II. A number of structurally distinct di- and oligosaccharides can be attached to the C-3 and C-2 of the backbone, respectively." [GOC:tair_curators]
synonym: "rhamnogalacturonan II side chain metabolism" EXACT []
is_a: GO:0010396 ! rhamnogalacturonan II metabolic process

[Term]
id: GO:0010420
name: polyprenyldihydroxybenzoate methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-polyprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-polyprenyl-4-hydroxy-5-methoxybenzoate (or 3-polyprenyl-5-hydroxy-4-methoxybenzoate)." [PMID:9628017]
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0010421
name: hydrogen peroxide-mediated programmed cell death
namespace: biological_process
def: "Programmed cell death induced by hydrogen peroxide. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [PMID:16036580]
is_a: GO:0012501 ! programmed cell death

[Term]
id: GO:0010422
name: regulation of brassinosteroid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903]
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process
relationship: regulates GO:0016132 ! brassinosteroid biosynthetic process

[Term]
id: GO:0010423
name: negative regulation of brassinosteroid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903]
is_a: GO:0010422 ! regulation of brassinosteroid biosynthetic process
is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process
relationship: negatively_regulates GO:0016132 ! brassinosteroid biosynthetic process

[Term]
id: GO:0010424
name: DNA methylation on cytosine within a CG sequence
namespace: biological_process
def: "The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule." [GOC:dph, GOC:tb, PMID:17239600]
synonym: "cytosine methylation within a CG sequence" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032776 ! DNA methylation on cytosine

[Term]
id: GO:0010425
name: DNA methylation on cytosine within a CNG sequence
namespace: biological_process
def: "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNG sequence in a DNA molecule. N stands for any nucleotide." [GOC:dph, GOC:tb, PMID:17239600]
synonym: "cytosine methylation within a CNG sequence" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032776 ! DNA methylation on cytosine

[Term]
id: GO:0010426
name: DNA methylation on cytosine within a CHH sequence
namespace: biological_process
def: "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within an asymmetric CHH sequence in a DNA molecule. H stands for an adenine, cytosine, or thymine nucleotide." [GOC:dph, GOC:mah, GOC:tb, PMID:15861207, PMID:17239600]
synonym: "cytosine methylation within a CHH sequence" EXACT [GOC:mah]
synonym: "cytosine methylation within a CNN sequence" EXACT [GOC:dph, GOC:tb]
synonym: "DNA methylation on cytosine within a CNN sequence" EXACT [GOC:mah]
is_a: GO:0032776 ! DNA methylation on cytosine

[Term]
id: GO:0010427
name: abscisic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with abscisic acid, plant hormones that regulate aspects of plant growth." [PMID:17347412]
synonym: "ABA binding" RELATED []
synonym: "abscisate binding" RELATED []
is_a: GO:0019840 ! isoprenoid binding
is_a: GO:0033293 ! monocarboxylic acid binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0010428
name: methyl-CpNpG binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a methylated cytosine/unspecified/guanine trinucleotide." [PMID:17239600]
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0010429
name: methyl-CpNpN binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a methylated cytosine/unspecified/unspecified trinucleotide." [PMID:17239600]
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0010430
name: fatty acid omega-oxidation
namespace: biological_process
def: "A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation." [MetaCyc:PWY-2724, PMID:16404574]
xref: MetaCyc:PWY-2724
is_a: GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0010431
name: seed maturation
namespace: biological_process
def: "A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination." [PMID:16096971]
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0010432
name: bract development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bract over time, from its formation to the mature structure. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055]
is_a: GO:0048827 ! phyllome development

[Term]
id: GO:0010433
name: bract morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of bract are generated and organized. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence. Morphogenesis pertains to the creation of form." [GOC:tb, PMID:16554366, PO:0009055]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0010432 ! bract development

[Term]
id: GO:0010434
name: bract formation
namespace: biological_process
def: "The process that gives rise to a bract. This process pertains to the initial formation of a structure from unspecified parts. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0010433 ! bract morphogenesis

[Term]
id: GO:0010435
name: 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid (OPC-8:0) + CoA = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)- cyclopentane-1-octanoyl-CoA." [PMID:16963437]
synonym: "OPC-8:0 CoA ligase activity" RELATED []
is_a: GO:0016405 ! CoA-ligase activity

[Term]
id: GO:0010436
name: carotenoid dioxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidative cleavage of carotenoids." [PMID:16459333]
synonym: "carotenoid-cleaving dioxygenase" RELATED []
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0010437
name: 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidative cleavage of carotenoids at the (9, 10) and/or (9', 10') double bond." [PMID:16459333]
is_a: GO:0010436 ! carotenoid dioxygenase activity

[Term]
id: GO:0010438
name: cellular response to sulfur starvation
namespace: biological_process
def: "A change in the state or activity of a cell (in terms of enzyme production, gene expression, etc.) as a result of deprivation of sulfur." [PMID:17420480]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0010439
name: regulation of glucosinolate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [PMID:17420480]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
is_a: GO:0043455 ! regulation of secondary metabolic process
relationship: regulates GO:0019761 ! glucosinolate biosynthetic process

[Term]
id: GO:0010440
name: stomatal lineage progression
namespace: biological_process
def: "The process by which an unspecialized epidermal cell progresses through a series of divisions that culminate in the production of a stomatal complex." [GOC:expert_db, GOC:tb]
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0010374 ! stomatal complex development

[Term]
id: GO:0010441
name: guard cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the guard cell over time, from its formation to the mature structure." [GOC:tb]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0010052 ! guard cell differentiation

[Term]
id: GO:0010442
name: guard cell morphogenesis
namespace: biological_process
def: "Generation and organization of the polarized cell that is capable of turgor driven movement." [GOC:expert_db, GOC:tb]
synonym: "guard cell morphogenesis during differentiation" EXACT []
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0010441 ! guard cell development

[Term]
id: GO:0010443
name: meristemoid mother cell division
namespace: biological_process
def: "The asymmetric cell division by which a meristemoid mother cells (MMC) give rise to a meristemoid and another cell. The other cell may itself become a MMC or may generate an epidermal cell. Any cell that undergoes this type of division is a MMC." [GOC:expert_db, GOC:tb]
synonym: "meristemoid division" RELATED []
is_a: GO:0000911 ! cytokinesis by cell plate formation
relationship: part_of GO:0010440 ! stomatal lineage progression

[Term]
id: GO:0010444
name: guard mother cell differentiation
namespace: biological_process
def: "The process by which a meristemoid acquires the specialized features of a guard mother cell." [GOC:expert_db, GOC:tb]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0010440 ! stomatal lineage progression

[Term]
id: GO:0010445
name: nuclear dicing body
namespace: cellular_component
def: "A small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes." [PMID:17442570]
synonym: "D body" EXACT []
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0010446
name: response to alkalinity
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7." [GOC:tb]
synonym: "response to alkaline pH" EXACT []
synonym: "response to basic pH" EXACT []
is_a: GO:0009268 ! response to pH

[Term]
id: GO:0010447
name: response to acidity
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7." [GOC:tb]
synonym: "response to acidic pH" EXACT []
is_a: GO:0009268 ! response to pH

[Term]
id: GO:0010448
name: vegetative meristem growth
namespace: biological_process
def: "The increase in size or mass of a vegetative meristem, a population of undifferentiated cells in a plant shoot which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into lateral organ primordia." [GOC:tb, ISBN:0849397928]
is_a: GO:0035266 ! meristem growth
relationship: part_of GO:0048367 ! shoot development

[Term]
id: GO:0010449
name: root meristem growth
namespace: biological_process
def: "The increase in size or mass of a root meristem, a population of undifferentiated cells in a plant root which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into the growth of the root." [GOC:tb]
is_a: GO:0035266 ! meristem growth
relationship: part_of GO:0048364 ! root development

[Term]
id: GO:0010450
name: inflorescence meristem growth
namespace: biological_process
def: "The increase in size or mass of an inflorescence meristem, a population of undifferentiated cells in a plant shoot which produces small leaves and then floral meristems, which will give rise to flowers." [GOC:tb]
is_a: GO:0035266 ! meristem growth
relationship: part_of GO:0010229 ! inflorescence development

[Term]
id: GO:0010451
name: floral meristem growth
namespace: biological_process
def: "The increase in size or mass of a floral meristem, a population of undifferentiated cells in a plant that gives rise to a flower." [GOC:tb]
is_a: GO:0035266 ! meristem growth
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0010452
name: histone H3-K36 methylation
namespace: biological_process
def: "The modification of histone H3 by addition of a methyl group to lysine at position 36 of the histone." [GOC:tb]
synonym: "histone H3 K36 methylation" EXACT [GOC:tb]
synonym: "histone H3K36me" EXACT [GOC:tb]
synonym: "histone lysine H3 K36 methylation" EXACT [GOC:tb]
is_a: GO:0034968 ! histone lysine methylation

[Term]
id: GO:0010453
name: regulation of cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0045165 ! cell fate commitment

[Term]
id: GO:0010454
name: negative regulation of cell fate commitment
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: negatively_regulates GO:0045165 ! cell fate commitment

[Term]
id: GO:0010455
name: positive regulation of cell fate commitment
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0045597 ! positive regulation of cell differentiation
relationship: positively_regulates GO:0045165 ! cell fate commitment

[Term]
id: GO:0010456
name: cell proliferation in dorsal spinal cord
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the dorsal spinal cord cell population." [GOC:dph, GOC:tb]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0010457
name: centriole-centriole cohesion
namespace: biological_process
def: "The process by which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb]
is_a: GO:0051297 ! centrosome organization

[Term]
id: GO:0010458
name: exit from mitosis
namespace: biological_process
def: "The cell cycle process where a cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0000087 ! M phase of mitotic cell cycle

[Term]
id: GO:0010459
name: negative regulation of heart rate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency or rate of heart contraction." [GOC:dph, GOC:tb]
is_a: GO:0002027 ! regulation of heart rate
is_a: GO:0045822 ! negative regulation of heart contraction

[Term]
id: GO:0010460
name: positive regulation of heart rate
namespace: biological_process
def: "Any process that activates or increases the frequency or rate of heart contraction." [GOC:dph, GOC:tb]
is_a: GO:0002027 ! regulation of heart rate
is_a: GO:0045823 ! positive regulation of heart contraction

[Term]
id: GO:0010461
name: light-activated channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a light stimulus." [GOC:dph, GOC:tb]
is_a: GO:0005216 ! ion channel activity

[Term]
id: GO:0010462
name: regulation of light-activated voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of light-activated voltage-gated calcium channel activity." [GOC:dph, GOC:tb]
is_a: GO:0016061 ! regulation of light-activated channel activity
is_a: GO:0050848 ! regulation of calcium-mediated signaling
is_a: GO:0051925 ! regulation of calcium ion transport via voltage-gated calcium channel activity

[Term]
id: GO:0010463
name: mesenchymal cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0010464
name: regulation of mesenchymal cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb]
is_a: GO:0042127 ! regulation of cell proliferation
relationship: regulates GO:0010463 ! mesenchymal cell proliferation

[Term]
id: GO:0010465
name: nerve growth factor receptor activity
namespace: molecular_function
def: "Combining with nerve growth factor, to block apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity." [GOC:dph, GOC:tb]
is_a: GO:0005030 ! neurotrophin receptor activity

[Term]
id: GO:0010466
name: negative regulation of peptidase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:0052547 ! regulation of peptidase activity

[Term]
id: GO:0010467
name: gene expression
namespace: biological_process
def: "The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
subset: gosubset_prok
xref: Reactome:448739 "Gene Expression"
xref: Reactome:469861 "Gene Expression"
xref: Reactome:487558 "Gene Expression"
xref: Reactome:507514 "Gene Expression"
xref: Reactome:517498 "Gene Expression"
xref: Reactome:526367 "Gene Expression"
xref: Reactome:531227 "Gene Expression"
xref: Reactome:536563 "Gene Expression"
xref: Reactome:542289 "Gene Expression"
xref: Reactome:547630 "Gene Expression"
xref: Reactome:552222 "Gene Expression"
xref: Reactome:557827 "Gene Expression"
xref: Reactome:568429 "Gene Expression"
xref: Reactome:581631 "Gene Expression"
xref: Reactome:585828 "Gene Expression"
xref: Reactome:592540 "Gene Expression"
xref: Reactome:595363 "Gene Expression"
xref: Reactome:597342 "Gene Expression"
xref: Reactome:598148 "Gene Expression"
xref: Reactome:599701 "Gene Expression"
xref: Reactome:600608 "Gene Expression"
xref: Reactome:602510 "Gene Expression"
xref: Reactome:74160 "Gene Expression"
xref: Wikipedia:Gene_expression
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0010468
name: regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "regulation of gene product expression" RELATED [GOC:curators]
synonym: "regulation of protein expression" NARROW [GOC:curators]
xref: Wikipedia:Regulation_of_gene_expression
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0010467 ! gene expression

[Term]
id: GO:0010469
name: regulation of receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:dph, GOC:tb]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0010470
name: regulation of gastrulation
namespace: biological_process
def: "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045995 ! regulation of embryonic development
relationship: regulates GO:0007369 ! gastrulation

[Term]
id: GO:0010471
name: GDP-galactose:mannose-1-phosphate guanyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-galactose-1-phosphate + mannose-1-phosphate = galactose-1-phosphate + GDP-mannose." [PMID:17485667]
is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity

[Term]
id: GO:0010472
name: GDP-galactose:glucose-1-phosphate guanyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-galactose-1-phosphate + glucose-1-phosphate = galactose-1-phosphate + GDP-glucose." [PMID:17485667]
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0010473
name: GDP-galactose:myoinositol-1-phosphate guanyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-galactose-1-phosphate + myoinositol-1-phosphate = galactose-1-phosphate + GDP-myoinositol." [PMID:17485667]
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0010474
name: glucose-1-phosphate guanylyltransferase (GDP) activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP + D-glucose 1-phosphate = phosphate + GDP-glucose." [PMID:17462988]
synonym: "GDP:Glucose-1- phosphate guanyltransferase activity " EXACT []
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0010475
name: galactose-1-phosphate guanylyltransferase (GDP) activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP + L-galactose 1-phosphate = phosphate + GDP-galactose." [PMID:17462988]
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0010476
name: gibberellin mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of gibberellin stimulus." [PMID:17521411]
synonym: "gibberellin-mediated signalling" EXACT [GOC:mah]
is_a: GO:0009755 ! hormone-mediated signaling pathway

[Term]
id: GO:0010477
name: response to sulfur dioxide
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus." [PMID:17425719]
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0010478
name: chlororespiration
namespace: biological_process
def: "A respiratory electron flow (from NAD(P)H to plastoquinone (PQ) and O2) involving both a nonphotochemical reduction and re-oxidation of PQ pool." [GOC:mtg_electron_transport, GOC:tb, PMID:17573537]
is_a: GO:0022904 ! respiratory electron transport chain

[Term]
id: GO:0010479
name: stele development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stele over time, from its formation to the mature structure. The stele is the central column of primary vascular tissue in the root and any tissue that it surrounds." [GOC:tb]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0048364 ! root development

[Term]
id: GO:0010480
name: microsporocyte differentiation
namespace: biological_process
def: "The process aimed at the progression of a microsporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A microsporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [CL:0000248 "Cell type ontology", PMID:16751349]
synonym: "pollen mother cell differentiation" RELATED []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048653 ! anther development

[Term]
id: GO:0010481
name: epidermal cell division
namespace: biological_process
def: "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells." [PMID:17450124]
synonym: "hypodermal cell division" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0051301 ! cell division

[Term]
id: GO:0010482
name: regulation of epidermal cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis." [PMID:17450124]
synonym: "regulation of hypodermal cell division" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0051302 ! regulation of cell division
relationship: regulates GO:0010481 ! epidermal cell division

[Term]
id: GO:0010483
name: pollen tube reception
namespace: biological_process
def: "Interaction between the pollen tube, part of the male gametophyte, and the ovule, part of the female gametophyte, that results in the arrest of pollen tube growth, rupture of the pollen tube and the release of the sperm cells." [GOC:tb, PMID:17673660]
is_a: GO:0051703 ! intraspecies interaction between organisms
relationship: part_of GO:0009856 ! pollination

[Term]
id: GO:0010484
name: H3 histone acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group to a histone, specific for histones H3." [PMID:17877703]
is_a: GO:0004402 ! histone acetyltransferase activity

[Term]
id: GO:0010485
name: H4 histone acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group to a histone, specific for histones H4." [PMID:17877703]
is_a: GO:0004402 ! histone acetyltransferase activity

[Term]
id: GO:0010486
name: manganese:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in)." [PMID:17559518]
synonym: "manganese:proton antiporter activity" EXACT [GOC:mah]
is_a: GO:0051139 ! metal ion:hydrogen antiporter activity

[Term]
id: GO:0010487
name: thermospermine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + thermospermine." [PMID:17560575]
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0010488
name: UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP." [PMID:17630273]
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0010489
name: UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-4-keto-6-deoxyglucose -> UDP-4-keto-rhamnose." [GOC:tair_curators, PMID:17190829]
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0010490
name: UDP-4-keto-rhamnose-4-keto-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH -> UDP-rhamnose + NADP+." [GOC:tair_curators, PMID:17190829]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0010491
name: UTP:arabinose-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate." [PMID:17341835]
is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity

[Term]
id: GO:0010492
name: maintenance of shoot apical meristem identity
namespace: biological_process
def: "The process by which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb, PMID:17461786]
is_a: GO:0010074 ! maintenance of meristem identity

[Term]
id: GO:0010493
name: Lewis a epitope biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a Lewis a epitope, a trisaccharide (Fuc-alpha-1->4(Gal-beta-1->3)GlcNAc) characteristic of plant protein N-linked oligosaccharides." [PMID:17630273]
synonym: "LE A biosynthetic process" RELATED []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process

[Term]
id: GO:0010494
name: stress granule
namespace: cellular_component
def: "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [PMID:17601829]
xref: Wikipedia:Stress_granule
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0010495
name: long-distance posttranscriptional gene silencing
namespace: biological_process
def: "A posttranscriptional gene silencing process in which the silencing signal originates in a tissue separate from the tissue in which the silencing takes place." [GOC:dph, GOC:tb, PMID:11590235, PMID:17785412]
synonym: "long-distance propagation of posttranscriptional gene silencing" EXACT [GOC:dph, GOC:tb]
is_a: GO:0016441 ! posttranscriptional gene silencing

[Term]
id: GO:0010496
name: intercellular transport
namespace: biological_process
def: "The movement of substances between cells in a multicellular organism." [GOC:dhl]
is_a: GO:0006810 ! transport
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0010497
name: plasmodesmata-mediated intercellular transport
namespace: biological_process
def: "The movement of substances between cells via plasmodesmata. Plasmodesmata is a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [PMID:17601829]
synonym: "plasmodesma-mediated cell-to-cell transport" EXACT []
synonym: "plasmodesma-mediated intercellular transport" EXACT []
synonym: "plasmodesmata-mediated cell-to-cell transport" EXACT []
is_a: GO:0010496 ! intercellular transport

[Term]
id: GO:0010498
name: proteasomal protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb]
synonym: "proteasome-mediated protein catabolic process" EXACT []
synonym: "proteasome-mediated protein catabolism" EXACT []
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process

[Term]
id: GO:0010499
name: proteasomal ubiquitin-independent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin." [GOC:tb]
is_a: GO:0010498 ! proteasomal protein catabolic process

[Term]
id: GO:0010500
name: transmitting tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of the transmitting tract over time, from its formation to the mature structure. The transmitting tissue is the tissue in the style of a carpel through which the pollen tube grows; it connects the stigma and the inside of ovary." [PMID:17855426]
is_a: GO:0048467 ! gynoecium development

[Term]
id: GO:0010501
name: RNA secondary structure unwinding
namespace: biological_process
def: "The process by which a secondary structure of RNA are broken or 'melted'." [PMID:17169986]
synonym: "RNA duplex unwinding" EXACT [GOC:ecd]
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0010502
name: plastoglobuli
namespace: cellular_component
def: "Lipid bodies localized within the chloroplast stroma." [PMID:17259290]
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0010503
name: negative regulation of cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb]
is_a: GO:0010504 ! regulation of cell cycle arrest in response to nitrogen starvation
is_a: GO:0010516 ! negative regulation of cellular response to nitrogen starvation
is_a: GO:0071157 ! negative regulation of cell cycle arrest
relationship: negatively_regulates GO:0030996 ! cell cycle arrest in response to nitrogen starvation

[Term]
id: GO:0010504
name: regulation of cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0071156 ! regulation of cell cycle arrest
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0030996 ! cell cycle arrest in response to nitrogen starvation

[Term]
id: GO:0010505
name: positive regulation of cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "Any process that increases the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb]
is_a: GO:0010504 ! regulation of cell cycle arrest in response to nitrogen starvation
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0032109 ! positive regulation of response to nutrient levels
is_a: GO:0071158 ! positive regulation of cell cycle arrest
relationship: positively_regulates GO:0030996 ! cell cycle arrest in response to nitrogen starvation

[Term]
id: GO:0010506
name: regulation of autophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process by which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
is_a: GO:0031329 ! regulation of cellular catabolic process
relationship: regulates GO:0006914 ! autophagy

[Term]
id: GO:0010507
name: negative regulation of autophagy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagy. Autophagy is the process by which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
is_a: GO:0010506 ! regulation of autophagy
is_a: GO:0031330 ! negative regulation of cellular catabolic process
relationship: negatively_regulates GO:0006914 ! autophagy

[Term]
id: GO:0010508
name: positive regulation of autophagy
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process by which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb]
is_a: GO:0010506 ! regulation of autophagy
is_a: GO:0031331 ! positive regulation of cellular catabolic process
relationship: positively_regulates GO:0006914 ! autophagy

[Term]
id: GO:0010509
name: polyamine homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal equilibrium of a polyamine." [GOC:dph, GOC:rph, GOC:tb, PMID:11161802, PMID:9761731]
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0010510
name: regulation of acetyl-CoA biosynthetic process from pyruvate
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:tb]
xref: Reactome:204174 "Regulation of pyruvate dehydrogenase complex (PDC)"
xref: Reactome:448712 "Regulation of pyruvate dehydrogenase complex (PDC)"
xref: Reactome:469834 "Regulation of pyruvate dehydrogenase complex (PDC)"
xref: Reactome:487528 "Regulation of pyruvate dehydrogenase complex (PDC)"
xref: Reactome:507485 "Regulation of pyruvate dehydrogenase complex (PDC)"
xref: Reactome:517470 "Regulation of pyruvate dehydrogenase complex (PDC)"
xref: Reactome:526340 "Regulation of pyruvate dehydrogenase complex (PDC)"
xref: Reactome:542565 "Regulation of pyruvate dehydrogenase complex (PDC)"
xref: Reactome:547885 "Regulation of pyruvate dehydrogenase complex (PDC)"
xref: Reactome:552462 "Regulation of pyruvate dehydrogenase complex (PDC)"
xref: Reactome:558069 "Regulation of pyruvate dehydrogenase complex (PDC)"
xref: Reactome:568719 "Regulation of pyruvate dehydrogenase complex (PDC)"
xref: Reactome:581922 "Regulation of pyruvate dehydrogenase complex (PDC)"
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
relationship: regulates GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate

[Term]
id: GO:0010511
name: regulation of phosphatidylinositol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw]
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
relationship: regulates GO:0006661 ! phosphatidylinositol biosynthetic process

[Term]
id: GO:0010512
name: negative regulation of phosphatidylinositol biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw]
is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process
is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process
relationship: negatively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process

[Term]
id: GO:0010513
name: positive regulation of phosphatidylinositol biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw]
is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process
is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process
relationship: positively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process

[Term]
id: GO:0010514
name: induction of conjugation with cellular fusion
namespace: biological_process
def: "The process by which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types." [GOC:dph, GOC:tb]
is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion

[Term]
id: GO:0010515
name: negative regulation of induction of conjugation with cellular fusion
namespace: biological_process
def: "The process by which a cell decreases the rate or frequency of the initiation of conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0031138 ! negative regulation of conjugation with cellular fusion
relationship: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion

[Term]
id: GO:0010516
name: negative regulation of cellular response to nitrogen starvation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cellular response to nitrogen starvation." [GOC:dph, GOC:tb]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0032108 ! negative regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: negatively_regulates GO:0006995 ! cellular response to nitrogen starvation

[Term]
id: GO:0010517
name: regulation of phospholipase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0060191 ! regulation of lipase activity

[Term]
id: GO:0010518
name: positive regulation of phospholipase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010517 ! regulation of phospholipase activity
is_a: GO:0060193 ! positive regulation of lipase activity

[Term]
id: GO:0010519
name: negative regulation of phospholipase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010517 ! regulation of phospholipase activity
is_a: GO:0060192 ! negative regulation of lipase activity

[Term]
id: GO:0010520
name: regulation of reciprocal meiotic recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0060631 ! regulation of meiosis I
relationship: regulates GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010521
name: telomerase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a telomerase. Telomerase catalyzes the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:dph, GOC:krc, GOC:tb]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0010522
name: regulation of calcium ion transport into cytosol
namespace: biological_process
def: "Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051924 ! regulation of calcium ion transport
relationship: regulates GO:0060402 ! calcium ion transport into cytosol

[Term]
id: GO:0010523
name: negative regulation of calcium ion transport into cytosol
namespace: biological_process
def: "Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb]
is_a: GO:0010522 ! regulation of calcium ion transport into cytosol
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051926 ! negative regulation of calcium ion transport
relationship: negatively_regulates GO:0060402 ! calcium ion transport into cytosol

[Term]
id: GO:0010524
name: positive regulation of calcium ion transport into cytosol
namespace: biological_process
def: "Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb]
is_a: GO:0010522 ! regulation of calcium ion transport into cytosol
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051928 ! positive regulation of calcium ion transport
relationship: positively_regulates GO:0060402 ! calcium ion transport into cytosol

[Term]
id: GO:0010525
name: regulation of transposition, RNA-mediated
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb]
is_a: GO:0010528 ! regulation of transposition
relationship: regulates GO:0032197 ! transposition, RNA-mediated

[Term]
id: GO:0010526
name: negative regulation of transposition, RNA-mediated
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb]
is_a: GO:0010525 ! regulation of transposition, RNA-mediated
is_a: GO:0010529 ! negative regulation of transposition
relationship: negatively_regulates GO:0032197 ! transposition, RNA-mediated

[Term]
id: GO:0010527
name: positive regulation of transposition, RNA-mediated
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb]
is_a: GO:0010525 ! regulation of transposition, RNA-mediated
is_a: GO:0010530 ! positive regulation of transposition
relationship: positively_regulates GO:0032197 ! transposition, RNA-mediated

[Term]
id: GO:0010528
name: regulation of transposition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]
subset: gosubset_prok
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0032196 ! transposition

[Term]
id: GO:0010529
name: negative regulation of transposition
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]
is_a: GO:0010528 ! regulation of transposition
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0032196 ! transposition

[Term]
id: GO:0010530
name: positive regulation of transposition
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb]
is_a: GO:0010528 ! regulation of transposition
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0032196 ! transposition

[Term]
id: GO:0010531
name: activation of JAK1 kinase activity
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a JAK1 (Janus Activated Kinase 1) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
synonym: "activation of JAK1 protein" EXACT [GOC:dph, GOC:tb]
synonym: "tyrosine phosphorylation of JAK1 protein" RELATED [GOC:dph, GOC:tb]
is_a: GO:0042976 ! activation of Janus kinase activity

[Term]
id: GO:0010532
name: regulation of activation of JAK1 kinase activity
namespace: biological_process
def: "Any process that modulates the frequency or rate of activation of JAK1 protein. The activation of JAK1 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK1 (Janus Activated Kinase 1) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
synonym: "regulation of activation of JAK1 protein" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of tyrosine phosphorylation of JAK1 protein" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010533 ! regulation of activation of Janus kinase activity
relationship: regulates GO:0010531 ! activation of JAK1 kinase activity

[Term]
id: GO:0010533
name: regulation of activation of Janus kinase activity
namespace: biological_process
def: "Any process that modulates the frequency or rate of activation of JAK protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:17190829, PMID:9135582]
synonym: "regulation of activation of JAK protein" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of tyrosine phosphorylation of JAK protein" RELATED [GOC:dph, GOC:tb]
is_a: GO:0046425 ! regulation of JAK-STAT cascade
is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation
relationship: regulates GO:0042976 ! activation of Janus kinase activity

[Term]
id: GO:0010534
name: regulation of activation of JAK2 kinase activity
namespace: biological_process
def: "Any process that modulates the frequency or rate of activation of JAK2 protein. The activation of JAK2 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
synonym: "regulation of activation of JAK2 protein" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010533 ! regulation of activation of Janus kinase activity
relationship: regulates GO:0042977 ! activation of JAK2 kinase activity

[Term]
id: GO:0010535
name: positive regulation of activation of JAK2 kinase activity
namespace: biological_process
def: "Any process that increase the frequency or rate of activation of JAK2 protein. The activation of JAK2 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
synonym: "positive regulation of activation of JAK2 protein" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010534 ! regulation of activation of JAK2 kinase activity
is_a: GO:0010536 ! positive regulation of activation of Janus kinase activity
relationship: positively_regulates GO:0042977 ! activation of JAK2 kinase activity

[Term]
id: GO:0010536
name: positive regulation of activation of Janus kinase activity
namespace: biological_process
def: "Any process that increases the frequency or rate of activation of JAK protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
synonym: "positive regulation of activation of JAK protein" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of tyrosine phosphorylation of JAK protein" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010533 ! regulation of activation of Janus kinase activity
is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
relationship: positively_regulates GO:0042976 ! activation of Janus kinase activity

[Term]
id: GO:0010537
name: positive regulation of activation of JAK1 kinase activity
namespace: biological_process
def: "Any process that increases the frequency or rate of activation of JAK1 protein. The activation of JAK1 protein is the process of introducing a phosphate group to a tyrosine residue of a JAK1 (Janus Activated Kinase 1) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582]
synonym: "positive regulation of activation of JAK1 protein" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of tyrosine phosphorylation of JAK1 protein" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010532 ! regulation of activation of JAK1 kinase activity
is_a: GO:0010536 ! positive regulation of activation of Janus kinase activity
relationship: positively_regulates GO:0010531 ! activation of JAK1 kinase activity

[Term]
id: GO:0010538
name: Hsp27 protein regulator activity
namespace: molecular_function
def: "OBSOLETE. Modulates the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb, PMID:11546764]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp27 protein activity'.
is_obsolete: true
replaced_by: GO:0051008
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0010539
name: Hsp27 protein inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp27 protein activity'.
is_obsolete: true
replaced_by: GO:0051008
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0010540
name: basipetal auxin transport
namespace: biological_process
def: "The unidirectional movement of auxin from the apex to base of an organ, including the shoot, leaf, primary root, or lateral root." [PMID:10677441]
is_a: GO:0009926 ! auxin polar transport

[Term]
id: GO:0010541
name: acropetal auxin transport
namespace: biological_process
def: "The unidirectional movement of auxin from the base towards the apex of an organ, including the shoot, leaf, primary root, or lateral root." [PMID:10677441]
is_a: GO:0009926 ! auxin polar transport

[Term]
id: GO:0010542
name: nitrate efflux transmembrane transporter activity
namespace: molecular_function
is_a: GO:0015113 ! nitrite transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0010543
name: regulation of platelet activation
namespace: biological_process
def: "Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0030193 ! regulation of blood coagulation
is_a: GO:0050865 ! regulation of cell activation
relationship: regulates GO:0030168 ! platelet activation

[Term]
id: GO:0010544
name: negative regulation of platelet activation
namespace: biological_process
def: "Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010543 ! regulation of platelet activation
is_a: GO:0030195 ! negative regulation of blood coagulation
is_a: GO:0050866 ! negative regulation of cell activation
relationship: negatively_regulates GO:0030168 ! platelet activation

[Term]
id: GO:0010545
name: Hsp90 protein regulator activity
namespace: molecular_function
def: "OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsp90." [GOC:dph, GOC:tb, PMID:11146632]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp90 protein activity'.
is_obsolete: true
replaced_by: GO:0051879
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0010546
name: Hsp90 protein inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the Hsp90 molecular chaperone." [GOC:dph, GOC:tb, PMID:11146632]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp90 protein activity'.
is_obsolete: true
replaced_by: GO:0051879
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0010547
name: thylakoid membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the thylakoid membrane in the context of a normal process." [GOC:dph, GOC:tb, PMID:17416733]
synonym: "thylakoid membrane degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010027 ! thylakoid membrane organization
is_a: GO:0030397 ! membrane disassembly

[Term]
id: GO:0010548
name: regulation of thylakoid membrane disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of thylakoid membrane disassembly." [GOC:dph, GOC:tb, PMID:17416733]
synonym: "regulation of thylakoid membrane degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010549 ! regulation of membrane disassembly
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0010547 ! thylakoid membrane disassembly

[Term]
id: GO:0010549
name: regulation of membrane disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of membrane disassembly." [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0030397 ! membrane disassembly

[Term]
id: GO:0010550
name: regulation of PSII associated light-harvesting complex II catabolic process
namespace: biological_process
def: "Any process that modulates the chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II." [GOC:dph, GOC:tb]
synonym: "regulation of LHCII catabolism" EXACT [GOC:dph, GOC:tb, PMID:17416733]
synonym: "regulation of LHCII degradation" EXACT [PMID:17416733]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
relationship: regulates GO:0010304 ! PSII associated light-harvesting complex II catabolic process

[Term]
id: GO:0010551
name: regulation of gene-specific transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific gene or set of genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter." [GOC:dph, GOC:tb]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0032583 ! regulation of gene-specific transcription
relationship: regulates GO:0032569 ! gene-specific transcription from RNA polymerase II promoter

[Term]
id: GO:0010552
name: positive regulation of gene-specific transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific gene or set of genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter." [GOC:dph, GOC:tb]
is_a: GO:0010551 ! regulation of gene-specific transcription from RNA polymerase II promoter
is_a: GO:0043193 ! positive regulation of gene-specific transcription
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
relationship: positively_regulates GO:0032569 ! gene-specific transcription from RNA polymerase II promoter

[Term]
id: GO:0010553
name: negative regulation of gene-specific transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific gene or set of genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter." [GOC:dph, GOC:tb]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0010551 ! regulation of gene-specific transcription from RNA polymerase II promoter
is_a: GO:0032582 ! negative regulation of gene-specific transcription
relationship: negatively_regulates GO:0032569 ! gene-specific transcription from RNA polymerase II promoter

[Term]
id: GO:0010554
name: neurotransmitter secretory pathway
namespace: biological_process
def: "A regulated secretory pathway in which neurotransmitters are initially stored in secretory vesicles for later release." [GOC:dph, GOC:tb]
is_a: GO:0045055 ! regulated secretory pathway
relationship: part_of GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0010555
name: response to mannitol stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [PMID:17999646]
is_a: GO:0009743 ! response to carbohydrate stimulus

[Term]
id: GO:0010556
name: regulation of macromolecule biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
subset: gosubset_prok
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0010557
name: positive regulation of macromolecule biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
relationship: positively_regulates GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0010558
name: negative regulation of macromolecule biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
relationship: negatively_regulates GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0010559
name: regulation of glycoprotein biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb]
subset: gosubset_prok
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
relationship: regulates GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0010560
name: positive regulation of glycoprotein biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
relationship: positively_regulates GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0010561
name: negative regulation of glycoprotein biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
relationship: negatively_regulates GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0010562
name: positive regulation of phosphorus metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0051174 ! regulation of phosphorus metabolic process
relationship: positively_regulates GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0010563
name: negative regulation of phosphorus metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0051174 ! regulation of phosphorus metabolic process
relationship: negatively_regulates GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0010564
name: regulation of cell cycle process
namespace: biological_process
def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]
is_a: GO:0051726 ! regulation of cell cycle
relationship: regulates GO:0022402 ! cell cycle process

[Term]
id: GO:0010565
name: regulation of cellular ketone metabolic process
namespace: biological_process
def: "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb]
is_a: GO:0031323 ! regulation of cellular metabolic process
relationship: regulates GO:0042180 ! cellular ketone metabolic process

[Term]
id: GO:0010566
name: regulation of ketone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells." [GOC:dph, GOC:tb]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
relationship: regulates GO:0042181 ! ketone biosynthetic process

[Term]
id: GO:0010567
name: regulation of ketone catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells." [GOC:dph, GOC:tb]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
relationship: regulates GO:0042182 ! ketone catabolic process

[Term]
id: GO:0010568
name: regulation of budding cell apical bud growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth at the tip of a bud, in a cell that reproduces by budding." [GOC:dph, GOC:jp, GOC:tb, PMID:17417630]
is_a: GO:0007116 ! regulation of cell budding
is_a: GO:0040008 ! regulation of growth
relationship: regulates GO:0007118 ! budding cell apical bud growth

[Term]
id: GO:0010569
name: regulation of double-strand break repair via homologous recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0006282 ! regulation of DNA repair
relationship: regulates GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:0010570
name: regulation of filamentous growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process by which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0040008 ! regulation of growth
relationship: regulates GO:0030447 ! filamentous growth

[Term]
id: GO:0010571
name: positive regulation of DNA replication during S phase
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA replication during progression through S phase of the cell cycle." [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0033262 ! regulation of DNA replication during S phase
is_a: GO:0045740 ! positive regulation of DNA replication
relationship: positively_regulates GO:0033260 ! DNA replication during S phase

[Term]
id: GO:0010572
name: positive regulation of platelet activation
namespace: biological_process
def: "Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0010543 ! regulation of platelet activation
is_a: GO:0050867 ! positive regulation of cell activation
relationship: positively_regulates GO:0030168 ! platelet activation

[Term]
id: GO:0010573
name: vascular endothelial growth factor production
namespace: biological_process
def: "The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rl]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0010574
name: regulation of vascular endothelial growth factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor." [GOC:rl]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0010573 ! vascular endothelial growth factor production

[Term]
id: GO:0010575
name: positive regulation vascular endothelial growth factor production
namespace: biological_process
def: "Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor." [GOC:BHF, GOC:rl]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0010574 ! regulation of vascular endothelial growth factor production
relationship: positively_regulates GO:0010573 ! vascular endothelial growth factor production

[Term]
id: GO:0010576
name: metalloenzyme regulator activity
namespace: molecular_function
def: "Modulates the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:dph, GOC:tb]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0010577
name: metalloenzyme activator activity
namespace: molecular_function
def: "Increases the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:dph, GOC:tb]
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0010576 ! metalloenzyme regulator activity

[Term]
id: GO:0010578
name: regulation of adenylate cyclase activity involved in G-protein signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adenylate cyclase activity that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP." [GOC:dph, GOC:tb]
synonym: "regulation of adenylate cyclase activity involved in G-protein signalling" EXACT [GOC:mah]
is_a: GO:0045761 ! regulation of adenylate cyclase activity
relationship: part_of GO:0007188 ! G-protein signaling, coupled to cAMP nucleotide second messenger

[Term]
id: GO:0010579
name: positive regulation of adenylate cyclase activity by G-protein signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of adenylate cyclase activity that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP." [GOC:dph, GOC:tb]
synonym: "positive regulation of adenylate cyclase activity by G-protein signalling pathway" EXACT [GOC:mah]
is_a: GO:0010578 ! regulation of adenylate cyclase activity involved in G-protein signaling pathway
is_a: GO:0045762 ! positive regulation of adenylate cyclase activity

[Term]
id: GO:0010581
name: regulation of starch biosynthetic process
namespace: biological_process
def: "An process which modulate the frequency, rate or extent of starch biosynthesis, the chemical reactions and pathways resulting in the formation of starch." [GOC:tb]
is_a: GO:0010962 ! regulation of glucan biosynthetic process
relationship: regulates GO:0019252 ! starch biosynthetic process

[Term]
id: GO:0010582
name: floral meristem determinacy
namespace: biological_process
def: "The process by which a floral meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [PMID:18441215]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0010022 ! meristem determinacy
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0010583
name: response to cyclopentenone
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid." [PMID:18334669]
is_a: GO:0014070 ! response to organic cyclic substance

[Term]
id: GO:0010584
name: pollen exine formation
namespace: biological_process
def: "The formation of the pollen exine. The reticulate pollen wall pattern consists of two layers, exine and intine." [GOC:dhl]
is_a: GO:0010208 ! pollen wall assembly

[Term]
id: GO:0010585
name: glutamine secretion
namespace: biological_process
def: "The controlled release of glutamine by a cell, a group of cells, or a tissue." [PMID:15208395]
is_a: GO:0006868 ! glutamine transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0010586
name: miRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620]
synonym: "microRNA metabolic process" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0010587
name: miRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620]
synonym: "microRNA catabolic process" EXACT []
is_a: GO:0010586 ! miRNA metabolic process
is_a: GO:0034661 ! ncRNA catabolic process

[Term]
id: GO:0010588
name: cotyledon vascular tissue pattern formation
namespace: biological_process
def: "Vascular tissue pattern formation as it occurs in the cotyledon of vascular plants." [PMID:10559439]
is_a: GO:0010051 ! xylem and phloem pattern formation

[Term]
id: GO:0010589
name: leaf proximal/distal pattern formation
namespace: biological_process
def: "The regionalization process within a leaf by which specific areas of cell differentiation are determined along a proximal/distal axis." [PMID:18398054]
is_a: GO:0009954 ! proximal/distal pattern formation

[Term]
id: GO:0010590
name: regulation of cell separation during cytokinesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the process of physically separating progeny cells during cytokinesis; this may involve enzymatic digestion of septum or cell wall components." [GOC:dph, GOC:tb]
is_a: GO:0032954 ! regulation of cytokinetic process
relationship: regulates GO:0000920 ! cell separation during cytokinesis

[Term]
id: GO:0010591
name: regulation of lamellipodium assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
synonym: "regulation of lamellipodium biogenesis" RELATED [GOC:mah]
is_a: GO:0060491 ! regulation of cell projection assembly
relationship: regulates GO:0030032 ! lamellipodium assembly

[Term]
id: GO:0010592
name: positive regulation of lamellipodium assembly
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
synonym: "positive regulation of lamellipodium biogenesis" RELATED [GOC:mah]
is_a: GO:0010591 ! regulation of lamellipodium assembly
is_a: GO:0031346 ! positive regulation of cell projection organization
relationship: positively_regulates GO:0030032 ! lamellipodium assembly

[Term]
id: GO:0010593
name: negative regulation of lamellipodium assembly
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb]
synonym: "negative regulation of lamellipodium biogenesis" RELATED [GOC:mah]
is_a: GO:0010591 ! regulation of lamellipodium assembly
is_a: GO:0031345 ! negative regulation of cell projection organization
relationship: negatively_regulates GO:0030032 ! lamellipodium assembly

[Term]
id: GO:0010594
name: regulation of endothelial cell migration
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0043542 ! endothelial cell migration

[Term]
id: GO:0010595
name: positive regulation of endothelial cell migration
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010594 ! regulation of endothelial cell migration
is_a: GO:0030335 ! positive regulation of cell migration
relationship: positively_regulates GO:0043542 ! endothelial cell migration

[Term]
id: GO:0010596
name: negative regulation of endothelial cell migration
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010594 ! regulation of endothelial cell migration
is_a: GO:0030336 ! negative regulation of cell migration
relationship: negatively_regulates GO:0043542 ! endothelial cell migration

[Term]
id: GO:0010597
name: green leaf volatile biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of volatile molecules emitted from green plants, such as hexenal, hexenol and hexenyl acetate, from linoleic acid or linolenic acid." [PMID:17163881]
is_a: GO:0019372 ! lipoxygenase pathway

[Term]
id: GO:0010598
name: NAD(P)H dehydrogenase complex (plastoquinone)
namespace: cellular_component
def: "Complex that possesses NAD(P)H dehydrogenase (plastoquinone) activity. The complex is one of the components of the electron transport chain. It is involved in electron transport from an unidentified electron donor, possibly NADH, NADPH or ferredoxin(Fd) to the plastoquinone pool." [PMID:15608332]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0010599
name: production of lsiRNA involved in RNA interference
namespace: biological_process
def: "Cleavage of double-stranded RNA to form lsiRNA (long small interfering RNA), a class of siRNAs 30 to 40 nt in length. lsiRNAs are induced by pathogen infection or under specific growth conditions." [PMID:18003861]
synonym: "RNA interference, production of lsiRNA" EXACT [GOC:mah]
is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA
relationship: part_of GO:0016246 ! RNA interference

[Term]
id: GO:0010600
name: regulation of auxin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [PMID:18287041]
is_a: GO:0046885 ! regulation of hormone biosynthetic process
relationship: regulates GO:0009851 ! auxin biosynthetic process

[Term]
id: GO:0010601
name: positive regulation of auxin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [PMID:18287041]
is_a: GO:0010600 ! regulation of auxin biosynthetic process
is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
relationship: positively_regulates GO:0009851 ! auxin biosynthetic process

[Term]
id: GO:0010602
name: regulation of 1-aminocyclopropane-1-carboxylate metabolic process
namespace: biological_process
def: "Regulation of the chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [PMID:18055613]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process

[Term]
id: GO:0010603
name: regulation of cytoplasmic mRNA processing body assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0033962 ! cytoplasmic mRNA processing body assembly

[Term]
id: GO:0010604
name: positive regulation of macromolecule metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: positively_regulates GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0010605
name: negative regulation of macromolecule metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: negatively_regulates GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0010606
name: positive regulation of cytoplasmic mRNA processing body assembly
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb]
is_a: GO:0010603 ! regulation of cytoplasmic mRNA processing body assembly
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0033962 ! cytoplasmic mRNA processing body assembly

[Term]
id: GO:0010607
name: negative regulation of cytoplasmic mRNA processing body assembly
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb]
is_a: GO:0010603 ! regulation of cytoplasmic mRNA processing body assembly
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0033962 ! cytoplasmic mRNA processing body assembly

[Term]
id: GO:0010608
name: posttranscriptional regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb]
is_a: GO:0010468 ! regulation of gene expression

[Term]
id: GO:0010609
name: posttranscriptional regulation of gene expression by mRNA localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression after the production of a mRNA transcript by its transport into, or maintainance in, a specific location within the cell." [GOC:dph, GOC:tb]
is_a: GO:0008298 ! intracellular mRNA localization
is_a: GO:0010608 ! posttranscriptional regulation of gene expression

[Term]
id: GO:0010610
name: regulation of mRNA stability involved in response to stress
namespace: biological_process
def: "Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance." [GOC:dph, GOC:tb]
is_a: GO:0043488 ! regulation of mRNA stability
relationship: part_of GO:0006950 ! response to stress

[Term]
id: GO:0010611
name: regulation of cardiac muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb]
is_a: GO:0014743 ! regulation of muscle hypertrophy
relationship: regulates GO:0003300 ! cardiac muscle hypertrophy

[Term]
id: GO:0010612
name: regulation of cardiac muscle adaptation
namespace: biological_process
def: "Any process that modulates the rate, extent or frequency of the process by which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:dph, GOC:tb]
is_a: GO:0043502 ! regulation of muscle adaptation
relationship: regulates GO:0014887 ! cardiac muscle adaptation

[Term]
id: GO:0010613
name: positive regulation of cardiac muscle hypertrophy
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy
is_a: GO:0014742 ! positive regulation of muscle hypertrophy
relationship: positively_regulates GO:0003300 ! cardiac muscle hypertrophy

[Term]
id: GO:0010614
name: negative regulation of cardiac muscle hypertrophy
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy
is_a: GO:0014741 ! negative regulation of muscle hypertrophy
relationship: negatively_regulates GO:0003300 ! cardiac muscle hypertrophy

[Term]
id: GO:0010615
name: positive regulation of cardiac muscle adaptation
namespace: biological_process
def: "Any process that increases the rate, extent or frequency of the process by which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010612 ! regulation of cardiac muscle adaptation
is_a: GO:0014744 ! positive regulation of muscle adaptation
relationship: positively_regulates GO:0014887 ! cardiac muscle adaptation

[Term]
id: GO:0010616
name: negative regulation of cardiac muscle adaptation
namespace: biological_process
def: "Any process that decreases the rate, extent or frequency of the process by which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010612 ! regulation of cardiac muscle adaptation
is_a: GO:0014745 ! negative regulation of muscle adaptation
relationship: negatively_regulates GO:0014887 ! cardiac muscle adaptation

[Term]
id: GO:0010617
name: circadian regulation of calcium ion oscillation
namespace: biological_process
def: "Any process that modulates the concentration of cytosolic free calcium ion [Ca2+]cyt with a regularity of approximately 24 hours." [PMID:17982000]
synonym: " circadian regulation of Ca2+ oscillation" RELATED []
synonym: "circadian regulation of [Ca2+]cyt oscillation" RELATED []
synonym: "circadian regulation of cytosolic calcium ion homeostasis" EXACT [GOC:dph, GOC:tb]
synonym: "circadian regulation of cytosolic free calcium ion oscillation" RELATED []
is_a: GO:0007623 ! circadian rhythm
is_a: GO:0051480 ! cytosolic calcium ion homeostasis

[Term]
id: GO:0010618
name: aerenchyma formation
namespace: biological_process
def: "The process that gives rise to aerenchyma, parenchyma tissue containing particularly large intercellular spaces of schizogenous or lysigenous origin. This process pertains to the initial formation of a structure from unspecified parts." [PMID:18055613, PO:0005702]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0010619
name: activation of adenylate cyclase activity by glucose-triggered G-protein signaling pathway
namespace: biological_process
def: "Any glucose-triggered process that initiates the activity of an inactive adenylate cyclase that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP." [GOC:dph, GOC:tb]
synonym: "activation of adenylate cyclase activity by glucose involved in G-protein signaling" EXACT [GOC:dph, GOC:tb]
synonym: "activation of adenylate cyclase activity by glucose-triggered G-protein signalling pathway" EXACT [GOC:mah]
is_a: GO:0007189 ! activation of adenylate cyclase activity by G-protein signaling pathway
is_a: GO:0010255 ! glucose mediated signaling pathway

[Term]
id: GO:0010620
name: negative regulation of transcription by transcription factor catabolism
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the catabolism of a transcription factor." [GOC:dph, GOC:tb]
is_a: GO:0044257 ! cellular protein catabolic process
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent

[Term]
id: GO:0010621
name: negative regulation of transcription by transcription factor localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor." [GOC:dph, GOC:tb]
is_a: GO:0034613 ! cellular protein localization
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent

[Term]
id: GO:0010622
name: specification of ovule identity
namespace: biological_process
def: "The regionalization process by which the identity of an ovule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0048482 ! ovule morphogenesis

[Term]
id: GO:0010623
name: developmental programmed cell death
namespace: biological_process
def: "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:tb]
is_a: GO:0012501 ! programmed cell death
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0048468 ! cell development

[Term]
id: GO:0010624
name: regulation of Schwann cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0060251 ! regulation of glial cell proliferation
relationship: regulates GO:0014010 ! Schwann cell proliferation

[Term]
id: GO:0010625
name: positive regulation of Schwann cell proliferation
namespace: biological_process
def: "Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0010624 ! regulation of Schwann cell proliferation
is_a: GO:0060252 ! positive regulation of glial cell proliferation
relationship: positively_regulates GO:0014010 ! Schwann cell proliferation

[Term]
id: GO:0010626
name: negative regulation of Schwann cell proliferation
namespace: biological_process
def: "Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0010624 ! regulation of Schwann cell proliferation
is_a: GO:0060253 ! negative regulation of glial cell proliferation
relationship: negatively_regulates GO:0014010 ! Schwann cell proliferation

[Term]
id: GO:0010627
name: regulation of protein kinase cascade
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0007243 ! protein kinase cascade

[Term]
id: GO:0010628
name: positive regulation of gene expression
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
relationship: positively_regulates GO:0010467 ! gene expression

[Term]
id: GO:0010629
name: negative regulation of gene expression
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
relationship: negatively_regulates GO:0010467 ! gene expression

[Term]
id: GO:0010630
name: regulation of transcription, start site selection
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA by a mechanism that selects the start site along that template." [GOC:dph, GOC:tb]
is_a: GO:0045449 ! regulation of transcription

[Term]
id: GO:0010631
name: epithelial cell migration
namespace: biological_process
def: "The orderly movement of epithelial cells from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0001667 ! ameboidal cell migration
relationship: part_of GO:0090132 ! epithelium migration

[Term]
id: GO:0010632
name: regulation of epithelial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0010631 ! epithelial cell migration

[Term]
id: GO:0010633
name: negative regulation of epithelial cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010632 ! regulation of epithelial cell migration
is_a: GO:0030336 ! negative regulation of cell migration
relationship: negatively_regulates GO:0010631 ! epithelial cell migration

[Term]
id: GO:0010634
name: positive regulation of epithelial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010632 ! regulation of epithelial cell migration
is_a: GO:0030335 ! positive regulation of cell migration
relationship: positively_regulates GO:0010631 ! epithelial cell migration

[Term]
id: GO:0010635
name: regulation of mitochondrial fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0008053 ! mitochondrial fusion

[Term]
id: GO:0010636
name: positive regulation of mitochondrial fusion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]
is_a: GO:0010635 ! regulation of mitochondrial fusion
is_a: GO:0010822 ! positive regulation of mitochondrion organization
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0008053 ! mitochondrial fusion

[Term]
id: GO:0010637
name: negative regulation of mitochondrial fusion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb]
is_a: GO:0010635 ! regulation of mitochondrial fusion
is_a: GO:0010823 ! negative regulation of mitochondrion organization
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0008053 ! mitochondrial fusion

[Term]
id: GO:0010638
name: positive regulation of organelle organization
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]
synonym: "positive regulation of organelle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0006996 ! organelle organization

[Term]
id: GO:0010639
name: negative regulation of organelle organization
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb]
synonym: "negative regulation of organelle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0006996 ! organelle organization

[Term]
id: GO:0010640
name: regulation of platelet-derived growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway

[Term]
id: GO:0010641
name: positive regulation of platelet-derived growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "positive regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway
relationship: positively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway

[Term]
id: GO:0010642
name: negative regulation of platelet-derived growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "negative regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway
relationship: negatively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway

[Term]
id: GO:0010643
name: cell communication by chemical coupling
namespace: biological_process
def: "The process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0007154 ! cell communication

[Term]
id: GO:0010644
name: cell communication by electrical coupling
namespace: biological_process
def: "The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0007154 ! cell communication

[Term]
id: GO:0010645
name: regulation of cell communication by chemical coupling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
relationship: regulates GO:0010643 ! cell communication by chemical coupling

[Term]
id: GO:0010646
name: regulation of cell communication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0007154 ! cell communication

[Term]
id: GO:0010647
name: positive regulation of cell communication
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0007154 ! cell communication

[Term]
id: GO:0010648
name: negative regulation of cell communication
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0007154 ! cell communication

[Term]
id: GO:0010649
name: regulation of cell communication by electrical coupling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
relationship: regulates GO:0010644 ! cell communication by electrical coupling

[Term]
id: GO:0010650
name: positive regulation of cell communication by electrical coupling
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0010649 ! regulation of cell communication by electrical coupling
relationship: positively_regulates GO:0010644 ! cell communication by electrical coupling

[Term]
id: GO:0010651
name: negative regulation of cell communication by electrical coupling
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0010649 ! regulation of cell communication by electrical coupling
relationship: negatively_regulates GO:0010644 ! cell communication by electrical coupling

[Term]
id: GO:0010652
name: positive regulation of cell communication by chemical coupling
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010645 ! regulation of cell communication by chemical coupling
is_a: GO:0010647 ! positive regulation of cell communication
relationship: positively_regulates GO:0010643 ! cell communication by chemical coupling

[Term]
id: GO:0010653
name: negative regulation of cell communication by chemical coupling
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0010645 ! regulation of cell communication by chemical coupling
is_a: GO:0010648 ! negative regulation of cell communication
relationship: negatively_regulates GO:0010643 ! cell communication by chemical coupling

[Term]
id: GO:0010654
name: apical cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into an apical cell. The apical cell is the upper cell formed after the first division of the zygote." [GOC:dph, GOC:tb]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0009793 ! embryonic development ending in seed dormancy

[Term]
id: GO:0010656
name: negative regulation of muscle cell apoptosis
namespace: biological_process
def: "Any process that decreases the rate or frequency of muscle cell apoptosis. Muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:tb]
is_a: GO:0010660 ! regulation of muscle cell apoptosis
is_a: GO:0043066 ! negative regulation of apoptosis
relationship: negatively_regulates GO:0010657 ! muscle cell apoptosis

[Term]
id: GO:0010657
name: muscle cell apoptosis
namespace: biological_process
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [GOC:dph, GOC:tb]
is_a: GO:0006915 ! apoptosis

[Term]
id: GO:0010658
name: striated muscle cell apoptosis
namespace: biological_process
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations." [GOC:dph, GOC:tb]
is_a: GO:0010657 ! muscle cell apoptosis

[Term]
id: GO:0010659
name: cardiac muscle cell apoptosis
namespace: biological_process
def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:dph, GOC:tb]
is_a: GO:0010658 ! striated muscle cell apoptosis

[Term]
id: GO:0010660
name: regulation of muscle cell apoptosis
namespace: biological_process
def: "Any process that modulates the rate or frequency of muscle cell apoptosis. Muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:tb]
is_a: GO:0042981 ! regulation of apoptosis
relationship: regulates GO:0010657 ! muscle cell apoptosis

[Term]
id: GO:0010661
name: positive regulation of muscle cell apoptosis
namespace: biological_process
def: "Any process that increases the rate or frequency of muscle cell apoptosis. Muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:tb]
is_a: GO:0010660 ! regulation of muscle cell apoptosis
is_a: GO:0043065 ! positive regulation of apoptosis
relationship: positively_regulates GO:0010657 ! muscle cell apoptosis

[Term]
id: GO:0010662
name: regulation of striated muscle cell apoptosis
namespace: biological_process
def: "Any process that modulates the rate or extent of striated muscle cell apoptosis. Striated muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:tb]
is_a: GO:0010660 ! regulation of muscle cell apoptosis
relationship: regulates GO:0010658 ! striated muscle cell apoptosis

[Term]
id: GO:0010663
name: positive regulation of striated muscle cell apoptosis
namespace: biological_process
def: "Any process that increases the rate or extent of striated muscle cell apoptosis. Striated muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:tb]
is_a: GO:0010661 ! positive regulation of muscle cell apoptosis
is_a: GO:0010662 ! regulation of striated muscle cell apoptosis
relationship: positively_regulates GO:0010658 ! striated muscle cell apoptosis

[Term]
id: GO:0010664
name: negative regulation of striated muscle cell apoptosis
namespace: biological_process
def: "Any process that increases the rate or extent of striated muscle cell apoptosis. Striated muscle cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
synonym: "down regulation of striated muscle cell apoptosis " EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "down-regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "downregulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "inhibition of striated muscle cell apoptosis " NARROW [GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0010656 ! negative regulation of muscle cell apoptosis
is_a: GO:0010662 ! regulation of striated muscle cell apoptosis
relationship: negatively_regulates GO:0010658 ! striated muscle cell apoptosis

[Term]
id: GO:0010665
name: regulation of cardiac muscle cell apoptosis
namespace: biological_process
def: "Any process that modulates the rate or extent of cardiac cell apoptosis. Cardiac cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:tb]
is_a: GO:0010662 ! regulation of striated muscle cell apoptosis
relationship: regulates GO:0010659 ! cardiac muscle cell apoptosis

[Term]
id: GO:0010666
name: positive regulation of cardiac muscle cell apoptosis
namespace: biological_process
def: "Any process that increases the rate or extent of cardiac cell apoptosis. Cardiac cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:tb]
is_a: GO:0010663 ! positive regulation of striated muscle cell apoptosis
is_a: GO:0010665 ! regulation of cardiac muscle cell apoptosis
relationship: positively_regulates GO:0010659 ! cardiac muscle cell apoptosis

[Term]
id: GO:0010667
name: negative regulation of cardiac muscle cell apoptosis
namespace: biological_process
def: "Any process that decreases the rate or extent of cardiac cell apoptosis. Cardiac cell apoptosis is a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
synonym: "down regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "down-regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "downregulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "inhibition of cardiac muscle cell apoptosis " NARROW [GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0010664 ! negative regulation of striated muscle cell apoptosis
is_a: GO:0010665 ! regulation of cardiac muscle cell apoptosis
relationship: negatively_regulates GO:0010659 ! cardiac muscle cell apoptosis

[Term]
id: GO:0010668
name: ectodermal cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:tb]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007398 ! ectoderm development

[Term]
id: GO:0010669
name: epithelial structure maintenance
namespace: biological_process
def: "A tissue homeostatic process required for the maintenance of epithelial structure." [GOC:dph, GOC:tb]
is_a: GO:0001894 ! tissue homeostasis

[Term]
id: GO:0010670
name: positive regulation of oxygen and reactive oxygen species metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0080010 ! regulation of oxygen and reactive oxygen species metabolic process
relationship: positively_regulates GO:0006800 ! oxygen and reactive oxygen species metabolic process

[Term]
id: GO:0010671
name: negative regulation of oxygen and reactive oxygen species metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0080010 ! regulation of oxygen and reactive oxygen species metabolic process
relationship: negatively_regulates GO:0006800 ! oxygen and reactive oxygen species metabolic process

[Term]
id: GO:0010672
name: regulation of transcription from RNA polymerase II promoter, meiotic
namespace: biological_process
def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter during meiosis." [GOC:dph, GOC:tb]
synonym: "regulation of transcription from RNA polymerase II promoter during meiosis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0051037 ! regulation of transcription, meiotic

[Term]
id: GO:0010673
name: positive regulation of transcription from RNA polymerase II promoter, meiotic
namespace: biological_process
def: "A cell cycle process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter during meiosis." [GOC:dph, GOC:tb]
synonym: "positive regulation of transcription from RNA polymerase II promoter during meiosis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter, meiotic
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0051039 ! positive regulation of transcription, meiotic

[Term]
id: GO:0010674
name: negative regulation of transcription from RNA polymerase II promoter, meiotic
namespace: biological_process
def: "A cell cycle process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter during meiosis." [GOC:dph, GOC:tb]
synonym: "negative regulation of transcription from RNA polymerase II promoter during meiosis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter, meiotic
is_a: GO:0051038 ! negative regulation of transcription, meiotic

[Term]
id: GO:0010675
name: regulation of cellular carbohydrate metabolic process
namespace: biological_process
def: "Any process that modulates the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
relationship: regulates GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0010676
name: positive regulation of cellular carbohydrate metabolic process
namespace: biological_process
def: "Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process
relationship: positively_regulates GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0010677
name: negative regulation of cellular carbohydrate metabolic process
namespace: biological_process
def: "Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process
relationship: negatively_regulates GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0010678
name: negative regulation of cellular carbohydrate metabolic process by repression of transcription
namespace: biological_process
def: "Any cellular process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates carried out by repression of transcription." [GOC:dph, GOC:tb]
synonym: "negative regulation of cellular carbohydrate metabolic process by transcriptional repression" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0016481 ! negative regulation of transcription

[Term]
id: GO:0010679
name: cinnamic acid biosynthetic process involved in salicylic acid metabolism
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of salicylic acid." [GOC:dph, GOC:tb]
is_a: GO:0009800 ! cinnamic acid biosynthetic process
relationship: part_of GO:0009696 ! salicylic acid metabolic process

[Term]
id: GO:0010680
name: cinnamic acid biosynthetic process involved in coumarin metabolism
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of coumarin." [GOC:dph, GOC:tb]
is_a: GO:0009800 ! cinnamic acid biosynthetic process
relationship: part_of GO:0009804 ! coumarin metabolic process

[Term]
id: GO:0010681
name: cinnamic biosynthetic process involved in stilbene metabolism
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of stilbene." [GOC:dph, GOC:tb]
is_a: GO:0009800 ! cinnamic acid biosynthetic process
relationship: part_of GO:0009810 ! stilbene metabolic process

[Term]
id: GO:0010682
name: cinnamic acid biosynthetic process involved in flavonoid metabolism
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of flavonoids." [GOC:dph, GOC:tb]
is_a: GO:0009800 ! cinnamic acid biosynthetic process
relationship: part_of GO:0009812 ! flavonoid metabolic process

[Term]
id: GO:0010683
name: tricyclic triterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings." [GOC:tair_curators]
synonym: "tricyclic triterpenoid metabolism" EXACT [GOC:tair_curators]
is_a: GO:0006722 ! triterpenoid metabolic process

[Term]
id: GO:0010684
name: tricyclic triterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings." [GOC:tair_curators]
synonym: "tricyclic triterpenoid catabolism" EXACT [GOC:tair_curators]
is_a: GO:0010683 ! tricyclic triterpenoid metabolic process
is_a: GO:0016105 ! triterpenoid catabolic process

[Term]
id: GO:0010685
name: tetracyclic triterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings." [GOC:tair_curators]
synonym: "tetracyclic triterpenoid metabolism" EXACT [GOC:tair_curators]
is_a: GO:0006722 ! triterpenoid metabolic process

[Term]
id: GO:0010686
name: tetracyclic triterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings." [GOC:tair_curators]
synonym: "tetracyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators]
is_a: GO:0010685 ! tetracyclic triterpenoid metabolic process
is_a: GO:0016104 ! triterpenoid biosynthetic process

[Term]
id: GO:0010687
name: cytokinesis during cell cycle, site selection
namespace: biological_process
def: "The process of marking the place where cytokinesis will occur in the context of cell cycle progression." [GOC:dph, GOC:tb]
is_a: GO:0007105 ! cytokinesis, site selection
relationship: part_of GO:0033205 ! cytokinesis during cell cycle

[Term]
id: GO:0010688
name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter." [GOC:dph, GOC:tb]
is_a: GO:0010553 ! negative regulation of gene-specific transcription from RNA polymerase II promoter
is_a: GO:0060962 ! regulation of ribosomal protein gene transcription from RNA polymerase II promoter

[Term]
id: GO:0010689
name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter, as a result of a chemical stimulus." [GOC:dph, GOC:tb]
is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0010690
name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter, as a result of a disturbance in organismal or cellular homeostasis." [GOC:dph, GOC:tb]
is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0010691
name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter, as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:dph, GOC:tb]
is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter
is_a: GO:0031669 ! cellular response to nutrient levels

[Term]
id: GO:0010692
name: regulation of alkaline phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb]
is_a: GO:0010921 ! regulation of phosphatase activity

[Term]
id: GO:0010693
name: negative regulation of alkaline phosphatase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010692 ! regulation of alkaline phosphatase activity
is_a: GO:0010923 ! negative regulation of phosphatase activity

[Term]
id: GO:0010694
name: positive regulation of alkaline phosphatase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb]
is_a: GO:0010692 ! regulation of alkaline phosphatase activity
is_a: GO:0010922 ! positive regulation of phosphatase activity

[Term]
id: GO:0010695
name: regulation of spindle pole body separation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339]
synonym: "regulation of SPB separation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
relationship: regulates GO:0000073 ! spindle pole body separation

[Term]
id: GO:0010696
name: positive regulation of spindle pole body separation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339]
synonym: "positive regulation of SPB separation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010695 ! regulation of spindle pole body separation
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0000073 ! spindle pole body separation

[Term]
id: GO:0010697
name: negative regulation of spindle pole body separation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339]
synonym: "negative regulation of SPB separation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010695 ! regulation of spindle pole body separation
is_a: GO:0010948 ! negative regulation of cell cycle process
relationship: negatively_regulates GO:0000073 ! spindle pole body separation

[Term]
id: GO:0010698
name: acetyltransferase activator activity
namespace: molecular_function
def: "Increases the activity of an aceyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule." [GOC:dph, GOC:jp, GOC:tb, PMID:18690240]
synonym: "acetyltransferase stimulator activity" EXACT [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0010699
name: cell-cell signaling involved in quorum sensing
namespace: biological_process
def: "The cell-cell signaling process in which single-celled organisms monitor population density by detecting the concentration of small diffusible signal molecules." [GOC:dph, GOC:tb]
synonym: "cell-cell signalling involved in quorum sensing" EXACT []
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0009372 ! quorum sensing

[Term]
id: GO:0010700
name: negative regulation of norepinephrine secretion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb]
is_a: GO:0014061 ! regulation of norepinephrine secretion
is_a: GO:0033604 ! negative regulation of catecholamine secretion
relationship: negatively_regulates GO:0048243 ! norepinephrine secretion

[Term]
id: GO:0010701
name: positive regulation of norepinephrine secretion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb]
is_a: GO:0014061 ! regulation of norepinephrine secretion
is_a: GO:0033605 ! positive regulation of catecholamine secretion
relationship: positively_regulates GO:0048243 ! norepinephrine secretion

[Term]
id: GO:0010702
name: regulation of histolysis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0007559 ! histolysis

[Term]
id: GO:0010703
name: negative regulation of histolysis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
synonym: "down regulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "down-regulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "downregulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb]
synonym: "inhibition of histolysis" NARROW [GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0010702 ! regulation of histolysis
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0007559 ! histolysis

[Term]
id: GO:0010704
name: meiotic DNA double-strand break processing involved in meiotic gene conversion
namespace: biological_process
def: "The cell cycle process whereby the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang resulting in the transfer of genetic information from one helix to another." [GOC:dph, GOC:tb]
is_a: GO:0000706 ! meiotic DNA double-strand break processing
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010705
name: meiotic DNA double-strand break processing involved in reciprocal meiotic recombination
namespace: biological_process
def: "The cell cycle process whereby the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs resulting in double strand break formation and repair through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000706 ! meiotic DNA double-strand break processing
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010706
name: biosynthesis of lactosylceramide precursor to ganglioside
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal beta(1,4)Glc beta(1,1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group as a precursor of gangliosides." [GOC:dph, GOC:tb]
synonym: "lactosylceramide biosynthesis leading to ganglioside" RELATED [GOC:dph, GOC:tb]
synonym: "lactosylceramide biosynthetic process leading to ganglioside" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001572 ! lactosylceramide biosynthetic process
is_a: GO:0001574 ! ganglioside biosynthetic process

[Term]
id: GO:0010707
name: biosynthesis of lactosylceramide precursor to globoside
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal beta(1,4)Glc beta(1,1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group as a precursor of globosides." [GOC:dph, GOC:tb]
synonym: "lactosylceramide biosynthesis leading to globoside" RELATED [GOC:dph, GOC:tb]
synonym: "lactosylceramide biosynthetic process leading to globoside" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001572 ! lactosylceramide biosynthetic process
is_a: GO:0001576 ! globoside biosynthetic process

[Term]
id: GO:0010708
name: heteroduplex formation involved in gene conversion at mating-type locus
namespace: biological_process
def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules resulting in the conversion of the mating-type locus from one allele to another." [GOC:dph, GOC:tb]
is_a: GO:0030491 ! heteroduplex formation
relationship: part_of GO:0007534 ! gene conversion at mating-type locus

[Term]
id: GO:0010709
name: heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing
namespace: biological_process
def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules resulting in the error-free repair of a double-strand break without the exchange of adjacent sequences." [GOC:dph, GOC:tb]
is_a: GO:0030491 ! heteroduplex formation
relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing

[Term]
id: GO:0010710
name: regulation of collagen catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of collagen degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010712 ! regulation of collagen metabolic process
relationship: regulates GO:0030574 ! collagen catabolic process

[Term]
id: GO:0010711
name: negative regulation of collagen catabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "down-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "downregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of collagen catabolic process" NARROW [GOC:dph, GOC:tb]
synonym: "negative regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of collagen degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010710 ! regulation of collagen catabolic process
is_a: GO:0010713 ! negative regulation of collagen metabolic process
relationship: negatively_regulates GO:0030574 ! collagen catabolic process

[Term]
id: GO:0010712
name: regulation of collagen metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb]
synonym: "regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb]
is_a: GO:0044246 ! regulation of multicellular organismal metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0032963 ! collagen metabolic process

[Term]
id: GO:0010713
name: negative regulation of collagen metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0010712 ! regulation of collagen metabolic process
is_a: GO:0044252 ! negative regulation of multicellular organismal metabolic process
relationship: negatively_regulates GO:0032963 ! collagen metabolic process

[Term]
id: GO:0010714
name: positive regulation of collagen metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb]
synonym: "positive regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0010712 ! regulation of collagen metabolic process
is_a: GO:0044253 ! positive regulation of multicellular organismal metabolic process
relationship: positively_regulates GO:0032963 ! collagen metabolic process

[Term]
id: GO:0010715
name: regulation of extracellular matrix disassembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0022617 ! extracellular matrix disassembly

[Term]
id: GO:0010716
name: negative regulation of extracellular matrix disassembly
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb]
synonym: "down-regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb]
synonym: "downregulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of extracellular matrix disassembly" NARROW [GOC:dph, GOC:tb]
synonym: "negative regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010715 ! regulation of extracellular matrix disassembly
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0022617 ! extracellular matrix disassembly

[Term]
id: GO:0010717
name: regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0001837 ! epithelial to mesenchymal transition

[Term]
id: GO:0010718
name: positive regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation
relationship: positively_regulates GO:0001837 ! epithelial to mesenchymal transition

[Term]
id: GO:0010719
name: negative regulation of epithelial to mesenchymal transition
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition
is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation
relationship: negatively_regulates GO:0001837 ! epithelial to mesenchymal transition

[Term]
id: GO:0010720
name: positive regulation of cell development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0060284 ! regulation of cell development
relationship: positively_regulates GO:0048468 ! cell development

[Term]
id: GO:0010721
name: negative regulation of cell development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0060284 ! regulation of cell development
relationship: negatively_regulates GO:0048468 ! cell development

[Term]
id: GO:0010722
name: regulation of ferrochelatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ferrochelatase activity; catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+." [GOC:dph, GOC:tb]
is_a: GO:0051339 ! regulation of lyase activity

[Term]
id: GO:0010723
name: positive regulation of transcription from RNA polymerase II promoter in response to iron
namespace: biological_process
def: "Any process that increases the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GOC:dph, GOC:tb]
is_a: GO:0010552 ! positive regulation of gene-specific transcription from RNA polymerase II promoter
is_a: GO:0034395 ! regulation of transcription from RNA polymerase II promoter in response to iron

[Term]
id: GO:0010724
name: regulation of definitive erythrocyte differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb]
synonym: "regulation of definitive erythropoiesis" EXACT [GOC:add, GOC:dph, GOC:tb]
synonym: "regulation of definitive RBC differentiation" EXACT [CL:0000232]
synonym: "regulation of definitive red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0045646 ! regulation of erythrocyte differentiation
relationship: regulates GO:0060318 ! definitive erythrocyte differentiation

[Term]
id: GO:0010725
name: regulation of primitive erythrocyte differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb]
synonym: "regulation of primitive erythropoeisis" EXACT [GOC:add, GOC:dph, GOC:tb]
synonym: "regulation of primitive RBC differentiation" EXACT [CL:0000232]
synonym: "regulation of primitive red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0045646 ! regulation of erythrocyte differentiation
is_a: GO:0045995 ! regulation of embryonic development
relationship: regulates GO:0060319 ! primitive erythrocyte differentiation

[Term]
id: GO:0010726
name: positive regulation of hydrogen peroxide metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "positive regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process
is_a: GO:0010670 ! positive regulation of oxygen and reactive oxygen species metabolic process
relationship: positively_regulates GO:0042743 ! hydrogen peroxide metabolic process

[Term]
id: GO:0010727
name: negative regulation of hydrogen peroxide metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "negative regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process
is_a: GO:0010671 ! negative regulation of oxygen and reactive oxygen species metabolic process
relationship: negatively_regulates GO:0042743 ! hydrogen peroxide metabolic process

[Term]
id: GO:0010728
name: regulation of hydrogen peroxide biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
relationship: regulates GO:0050665 ! hydrogen peroxide biosynthetic process

[Term]
id: GO:0010729
name: positive regulation of hydrogen peroxide biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "positive regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010726 ! positive regulation of hydrogen peroxide metabolic process
is_a: GO:0010728 ! regulation of hydrogen peroxide biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
relationship: positively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process

[Term]
id: GO:0010730
name: negative regulation of hydrogen peroxide biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb]
synonym: "negative regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0010727 ! negative regulation of hydrogen peroxide metabolic process
is_a: GO:0010728 ! regulation of hydrogen peroxide biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
relationship: negatively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process

[Term]
id: GO:0010731
name: protein amino acid glutathionylation
namespace: biological_process
def: "The protein modification process by which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0006464 ! protein modification process

[Term]
id: GO:0010732
name: regulation of protein amino acid glutathionylation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of protein amino acid glutathionylation. Protein amino acid glutathionylation is the protein modification process by which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0010731 ! protein amino acid glutathionylation

[Term]
id: GO:0010733
name: positive regulation of protein amino acid glutathionylation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of protein amino acid glutathionylation. Protein amino acid glutathionylation is the protein modification process by which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0010732 ! regulation of protein amino acid glutathionylation
is_a: GO:0031401 ! positive regulation of protein modification process
relationship: positively_regulates GO:0010731 ! protein amino acid glutathionylation

[Term]
id: GO:0010734
name: negative regulation of protein amino acid glutathionylation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of protein amino acid glutathionylation. Protein amino acid glutathionylation is the protein modification process by which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0010732 ! regulation of protein amino acid glutathionylation
is_a: GO:0031400 ! negative regulation of protein modification process
relationship: negatively_regulates GO:0010731 ! protein amino acid glutathionylation

[Term]
id: GO:0010735
name: positive regulation of transcription via serum response element binding
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific set of genes as a result of a transcription factor interacting with a serum response element (SRE). A serum response element is a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0010552 ! positive regulation of gene-specific transcription from RNA polymerase II promoter

[Term]
id: GO:0010736
name: serum response element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0010843 ! promoter binding

[Term]
id: GO:0010737
name: protein kinase A signaling cascade
namespace: biological_process
def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "PKA signaling cascade" EXACT [GOC:dph, GOC:tb]
synonym: "protein kinase A signalling cascade" EXACT [GOC:mah]
is_a: GO:0007243 ! protein kinase cascade

[Term]
id: GO:0010738
name: regulation of protein kinase A signaling cascade
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the protein kinase A signaling cascade. The PKA signaling cascade is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of PKA signaling cascade" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of protein kinase A signalling cascade" EXACT [GOC:mah]
is_a: GO:0010627 ! regulation of protein kinase cascade
relationship: regulates GO:0010737 ! protein kinase A signaling cascade

[Term]
id: GO:0010739
name: positive regulation of protein kinase A signaling cascade
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the protein kinase A signaling cascade. The PKA signaling cascade is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of PKA signaling cascade" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of protein kinase A signalling cascade" EXACT [GOC:mah]
is_a: GO:0010738 ! regulation of protein kinase A signaling cascade
is_a: GO:0010740 ! positive regulation of protein kinase cascade
relationship: positively_regulates GO:0010737 ! protein kinase A signaling cascade

[Term]
id: GO:0010740
name: positive regulation of protein kinase cascade
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0010627 ! regulation of protein kinase cascade
relationship: positively_regulates GO:0007243 ! protein kinase cascade

[Term]
id: GO:0010741
name: negative regulation of protein kinase cascade
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0010627 ! regulation of protein kinase cascade
relationship: negatively_regulates GO:0007243 ! protein kinase cascade

[Term]
id: GO:0010742
name: macrophage derived foam cell differentiation
namespace: biological_process
def: "The process whereby a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb]
is_a: GO:0090077 ! foam cell differentiation

[Term]
id: GO:0010743
name: regulation of macrophage derived foam cell differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process whereby a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0010742 ! macrophage derived foam cell differentiation

[Term]
id: GO:0010744
name: positive regulation of macrophage derived foam cell differentiation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process whereby a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb]
is_a: GO:0010743 ! regulation of macrophage derived foam cell differentiation
is_a: GO:0045597 ! positive regulation of cell differentiation
relationship: positively_regulates GO:0010742 ! macrophage derived foam cell differentiation

[Term]
id: GO:0010745
name: negative regulation of macrophage derived foam cell differentiation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process whereby a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb]
is_a: GO:0010743 ! regulation of macrophage derived foam cell differentiation
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: negatively_regulates GO:0010742 ! macrophage derived foam cell differentiation

[Term]
id: GO:0010746
name: regulation of plasma membrane long-chain fatty acid transport
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0032890 ! regulation of organic acid transport
relationship: regulates GO:0015911 ! plasma membrane long-chain fatty acid transport

[Term]
id: GO:0010747
name: positive regulation of plasma membrane long-chain fatty acid transport
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010746 ! regulation of plasma membrane long-chain fatty acid transport
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0032892 ! positive regulation of organic acid transport
relationship: positively_regulates GO:0015911 ! plasma membrane long-chain fatty acid transport

[Term]
id: GO:0010748
name: negative regulation of plasma membrane long-chain fatty acid transport
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010746 ! regulation of plasma membrane long-chain fatty acid transport
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0032891 ! negative regulation of organic acid transport
relationship: negatively_regulates GO:0015911 ! plasma membrane long-chain fatty acid transport

[Term]
id: GO:0010749
name: regulation of nitric oxide mediated signal transduction
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of nitric oxide-mediated signal transduction" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0007263 ! nitric oxide mediated signal transduction

[Term]
id: GO:0010750
name: positive regulation of nitric oxide mediated signal transduction
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of nitric oxide-mediated signal transduction" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction
relationship: positively_regulates GO:0007263 ! nitric oxide mediated signal transduction

[Term]
id: GO:0010751
name: negative regulation of nitric oxide mediated signal transduction
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of nitric oxide-mediated signal transduction" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction
relationship: negatively_regulates GO:0007263 ! nitric oxide mediated signal transduction

[Term]
id: GO:0010752
name: regulation of cGMP-mediated signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of cGMP-mediated signalling" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0019934 ! cGMP-mediated signaling

[Term]
id: GO:0010753
name: positive regulation of cGMP-mediated signaling
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of cGMP-mediated signalling" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0010752 ! regulation of cGMP-mediated signaling
relationship: positively_regulates GO:0019934 ! cGMP-mediated signaling

[Term]
id: GO:0010754
name: negative regulation of cGMP-mediated signaling
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of cGMP-mediated signalling" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0010752 ! regulation of cGMP-mediated signaling
relationship: negatively_regulates GO:0019934 ! cGMP-mediated signaling

[Term]
id: GO:0010755
name: regulation of plasminogen activation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process whereby plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010953 ! regulation of protein maturation by peptide bond cleavage
relationship: regulates GO:0031639 ! plasminogen activation

[Term]
id: GO:0010756
name: positive regulation of plasminogen activation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process whereby plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010755 ! regulation of plasminogen activation
is_a: GO:0010954 ! positive regulation of protein maturation by peptide bond cleavage
relationship: positively_regulates GO:0031639 ! plasminogen activation

[Term]
id: GO:0010757
name: negative regulation of plasminogen activation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process whereby plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "inhibition of plasminogen activation" NARROW [GOC:dph, GOC:tb]
is_a: GO:0010755 ! regulation of plasminogen activation
is_a: GO:0010955 ! negative regulation of protein maturation by peptide bond cleavage
relationship: negatively_regulates GO:0031639 ! plasminogen activation

[Term]
id: GO:0010758
name: regulation of macrophage chemotaxis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
relationship: regulates GO:0048246 ! macrophage chemotaxis

[Term]
id: GO:0010759
name: positive regulation of macrophage chemotaxis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0010758 ! regulation of macrophage chemotaxis
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
is_a: GO:0071675 ! regulation of mononuclear cell migration
relationship: positively_regulates GO:0048246 ! macrophage chemotaxis

[Term]
id: GO:0010760
name: negative regulation of macrophage chemotaxis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0010758 ! regulation of macrophage chemotaxis
relationship: negatively_regulates GO:0048246 ! macrophage chemotaxis

[Term]
id: GO:0010761
name: fibroblast migration
namespace: biological_process
def: "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0001667 ! ameboidal cell migration

[Term]
id: GO:0010762
name: regulation of fibroblast migration
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb]
synonym: "regulation of fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0010761 ! fibroblast migration

[Term]
id: GO:0010763
name: positive regulation of fibroblast migration
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0010762 ! regulation of fibroblast migration
is_a: GO:0030335 ! positive regulation of cell migration
relationship: positively_regulates GO:0010761 ! fibroblast migration

[Term]
id: GO:0010764
name: negative regulation of fibroblast migration
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb]
synonym: "negative regulation of fibroblast cell migration" EXACT [GOC:dph]
is_a: GO:0010762 ! regulation of fibroblast migration
is_a: GO:0030336 ! negative regulation of cell migration
relationship: negatively_regulates GO:0010761 ! fibroblast migration

[Term]
id: GO:0010765
name: positive regulation of sodium ion transport
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0002028 ! regulation of sodium ion transport
is_a: GO:0043270 ! positive regulation of ion transport
relationship: positively_regulates GO:0006814 ! sodium ion transport

[Term]
id: GO:0010766
name: negative regulation of sodium ion transport
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0002028 ! regulation of sodium ion transport
is_a: GO:0043271 ! negative regulation of ion transport
relationship: negatively_regulates GO:0006814 ! sodium ion transport

[Term]
id: GO:0010767
name: regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb]
is_a: GO:0034644 ! cellular response to UV
is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress

[Term]
id: GO:0010768
name: negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb]
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0010767 ! regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage

[Term]
id: GO:0010769
name: regulation of cell morphogenesis involved in differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb]
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0000904 ! cell morphogenesis involved in differentiation

[Term]
id: GO:0010770
name: positive regulation of cell morphogenesis involved in differentiation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0000904 ! cell morphogenesis involved in differentiation

[Term]
id: GO:0010771
name: negative regulation of cell morphogenesis involved in differentiation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0000904 ! cell morphogenesis involved in differentiation

[Term]
id: GO:0010772
name: meiotic DNA recombinase assembly involved in reciprocal meiotic recombination
namespace: biological_process
def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic recombination. Meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000707 ! meiotic DNA recombinase assembly
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010773
name: meiotic DNA recombinase assembly involved in meiotic gene conversion
namespace: biological_process
def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process whereby genetic information is transferred from one helix to another." [GOC:dph, GOC:tb]
is_a: GO:0000707 ! meiotic DNA recombinase assembly
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010774
name: meiotic strand invasion involved in reciprocal meiotic recombination
namespace: biological_process
def: "The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination. Meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000708 ! meiotic strand invasion
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010775
name: meiotic strand invasion involved in meiotic gene conversion
namespace: biological_process
def: "The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination." [GOC:dph, GOC:tb]
is_a: GO:0000708 ! meiotic strand invasion
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010776
name: meiotic mismatch repair involved in meiotic gene conversion
namespace: biological_process
def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process whereby genetic information is transferred from one helix to another." [GOC:dph, GOC:tb]
is_a: GO:0000710 ! meiotic mismatch repair
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010777
name: meiotic mismatch repair involved in reciprocal meiotic recombination
namespace: biological_process
def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic recombination. Meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000710 ! meiotic mismatch repair
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010778
name: meiotic DNA repair synthesis involved in reciprocal meiotic recombination
namespace: biological_process
def: "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic recombination. Meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0000711 ! meiotic DNA repair synthesis
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010779
name: meiotic DNA repair synthesis involved in meiotic gene conversion
namespace: biological_process
def: "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process whereby genetic information is transferred from one helix to another." [GOC:dph, GOC:tb]
is_a: GO:0000711 ! meiotic DNA repair synthesis
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010780
name: meiotic DNA double-strand break formation involved in reciprocal meiotic recombination
namespace: biological_process
def: "The cell cycle process whereby double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic recombination. Meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
is_a: GO:0042138 ! meiotic DNA double-strand break formation
relationship: part_of GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010781
name: meiotic DNA double-strand break formation involved in meiotic gene conversion
namespace: biological_process
def: "The cell cycle process whereby double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process whereby genetic information is transferred from one helix to another." [GOC:dph, GOC:tb]
is_a: GO:0042138 ! meiotic DNA double-strand break formation
relationship: part_of GO:0006311 ! meiotic gene conversion

[Term]
id: GO:0010782
name: proboscis morphogenesis, labial disc-derived
namespace: biological_process
def: "The process by which the anatomical structures of the proboscis that are derived from the labial disc are generated and organized." [GOC:dph, GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007454 ! labial disc morphogenesis
relationship: part_of GO:0048734 ! proboscis morphogenesis

[Term]
id: GO:0010783
name: proboscis morphogenesis, eye-antennal disc-derived
namespace: biological_process
def: "The process by which the anatomical structures of the proboscis that are derived from the eye-antennal disc are generated and organized." [GOC:dph, GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis
relationship: part_of GO:0048734 ! proboscis morphogenesis

[Term]
id: GO:0010784
name: proboscis morphogenesis, clypeo-labral disc-derived
namespace: biological_process
def: "The process by which the anatomical structures of the proboscis that are derived from the clypeo-labral disc are generated and organized." [GOC:dph, GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048734 ! proboscis morphogenesis

[Term]
id: GO:0010785
name: clathrin coating of Golgi vesicle, plasma membrane to endosome targeting
namespace: biological_process
def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the plasma membrane to the endosome, forming a vesicle coat." [GOC:dph, GOC:tb]
is_a: GO:0048202 ! clathrin coating of Golgi vesicle
relationship: part_of GO:0048201 ! vesicle targeting, plasma membrane to endosome

[Term]
id: GO:0010786
name: clathrin coating of Golgi vesicle, trans-Golgi to endosome targeting
namespace: biological_process
def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the trans-Golgi to the endosome, forming a vesicle coat." [GOC:dph, GOC:tb]
is_a: GO:0048202 ! clathrin coating of Golgi vesicle
relationship: part_of GO:0048203 ! vesicle targeting, trans-Golgi to endosome

[Term]
id: GO:0010787
name: COPI coating of Golgi vesicle, inter-Golgi cisterna
namespace: biological_process
def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of inter-Golgi cisterna transport vesicles, forming a vesicle coat." [GOC:dph, GOC:tb]
is_a: GO:0048205 ! COPI coating of Golgi vesicle
relationship: part_of GO:0048204 ! vesicle targeting, inter-Golgi cisterna

[Term]
id: GO:0010788
name: COPI coating of Golgi vesicle, cis-Golgi to rough ER
namespace: biological_process
def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of cis-Golgi to rough ER transport vesicles, forming a vesicle coat." [GOC:dph, GOC:tb]
is_a: GO:0048205 ! COPI coating of Golgi vesicle
relationship: part_of GO:0048206 ! vesicle targeting, cis-Golgi to rough ER

[Term]
id: GO:0010789
name: meiotic sister chromatid cohesion involved in meiosis I
namespace: biological_process
def: "The cell cycle process whereby sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis I." [GOC:dph, GOC:tb]
is_a: GO:0051177 ! meiotic sister chromatid cohesion
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0010790
name: meiotic sister chromatid cohesion involved in meiosis II
namespace: biological_process
def: "The cell cycle process whereby sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis II." [GOC:dph, GOC:tb]
is_a: GO:0051177 ! meiotic sister chromatid cohesion
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0010791
name: DNA double-strand break processing involved in repair via synthesis-dependent strand annealing
namespace: biological_process
def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via synthesis-dependent strand annealing." [GOC:dph, GOC:tb]
is_a: GO:0000729 ! DNA double-strand break processing
relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing

[Term]
id: GO:0010792
name: DNA double-strand break processing involved in repair via single-strand annealing
namespace: biological_process
def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing." [GOC:dph, GOC:tb]
is_a: GO:0000729 ! DNA double-strand break processing
relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing

[Term]
id: GO:0010793
name: regulation of mRNA export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm." [GOC:dph, GOC:tb]
is_a: GO:0046831 ! regulation of RNA export from nucleus
relationship: regulates GO:0006406 ! mRNA export from nucleus

[Term]
id: GO:0010794
name: regulation of dolichol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dolichol biosynthesis. Dolichol biosynthesis consists of the chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [GOC:dph, GOC:tb]
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: regulates GO:0019408 ! dolichol biosynthetic process

[Term]
id: GO:0010795
name: regulation of ubiquinone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:dph, GOC:tb]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
relationship: regulates GO:0006744 ! ubiquinone biosynthetic process

[Term]
id: GO:0010796
name: regulation of multivesicular body size
namespace: biological_process
def: "Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles." [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0051036 ! regulation of endosome size

[Term]
id: GO:0010797
name: regulation of multivesicular body size involved in endosome transport
namespace: biological_process
def: "Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles." [GOC:dph, GOC:tb]
is_a: GO:0010796 ! regulation of multivesicular body size
relationship: part_of GO:0032509 ! endosome transport via multivesicular body sorting pathway

[Term]
id: GO:0010798
name: regulation of multivesicular body size involved in ubiquitin-dependent protein catabolism
namespace: biological_process
def: "Any process that modulates the volume of a multivesicular body as part of the chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin." [GOC:dph, GOC:tb]
is_a: GO:0010796 ! regulation of multivesicular body size

[Term]
id: GO:0010799
name: regulation of peptidyl-threonine phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the posttranslational phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb]
is_a: GO:0001932 ! regulation of protein amino acid phosphorylation
relationship: regulates GO:0018107 ! peptidyl-threonine phosphorylation

[Term]
id: GO:0010800
name: positive regulation of peptidyl-threonine phosphorylation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the posttranslational phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb]
is_a: GO:0001934 ! positive regulation of protein amino acid phosphorylation
is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation
relationship: positively_regulates GO:0018107 ! peptidyl-threonine phosphorylation

[Term]
id: GO:0010801
name: negative regulation of peptidyl-threonine phosphorylation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the posttranslational phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb]
is_a: GO:0001933 ! negative regulation of protein amino acid phosphorylation
is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation
relationship: negatively_regulates GO:0018107 ! peptidyl-threonine phosphorylation

[Term]
id: GO:0010803
name: regulation of tumor necrosis factor-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb]
synonym: "regulation of TNF signaling" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of TNF-mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway

[Term]
id: GO:0010804
name: negative regulation of tumor necrosis factor-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb]
synonym: "negative regulation of TNF signaling" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of TNF-mediated signaling pathway" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0010803 ! regulation of tumor necrosis factor-mediated signaling pathway
relationship: negatively_regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway

[Term]
id: GO:0010805
name: regulation of lysine import
namespace: biological_process
def: "Any process that modulates the rate or frequency of lysine import. Lysine import is the directed movement of lysine, 2,6-diaminohexanoic acid, into a cell or organelle." [GOC:dph, GOC:tb]
synonym: "regulation of lysine uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010958 ! regulation of amino acid import
relationship: regulates GO:0034226 ! lysine import

[Term]
id: GO:0010806
name: negative regulation of lysine import
namespace: biological_process
def: "Any process that decreases the rate or frequency of lysine import. Lysine import is the directed movement of lysine, 2,6-diaminohexanoic acid, into a cell or organelle." [GOC:dph, GOC:tb]
synonym: "negative regulation of lysine uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010805 ! regulation of lysine import
is_a: GO:0051956 ! negative regulation of amino acid transport
relationship: negatively_regulates GO:0034226 ! lysine import

[Term]
id: GO:0010807
name: regulation of synaptic vesicle priming
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kva, GOC:tb, PMID:15489511]
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0046928 ! regulation of neurotransmitter secretion
relationship: regulates GO:0016082 ! synaptic vesicle priming

[Term]
id: GO:0010808
name: positive regulation of synaptic vesicle priming
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kva, GOC:tb, PMID:15489511]
is_a: GO:0010807 ! regulation of synaptic vesicle priming
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0016082 ! synaptic vesicle priming

[Term]
id: GO:0010809
name: negative regulation of synaptic vesicle priming
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kva, GOC:tb, PMID:15489511]
is_a: GO:0010807 ! regulation of synaptic vesicle priming
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0016082 ! synaptic vesicle priming

[Term]
id: GO:0010810
name: regulation of cell-substrate adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb]
is_a: GO:0030155 ! regulation of cell adhesion
relationship: regulates GO:0031589 ! cell-substrate adhesion

[Term]
id: GO:0010811
name: positive regulation of cell-substrate adhesion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb]
is_a: GO:0010810 ! regulation of cell-substrate adhesion
is_a: GO:0045785 ! positive regulation of cell adhesion
relationship: positively_regulates GO:0031589 ! cell-substrate adhesion

[Term]
id: GO:0010812
name: negative regulation of cell-substrate adhesion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb]
is_a: GO:0007162 ! negative regulation of cell adhesion
is_a: GO:0010810 ! regulation of cell-substrate adhesion
relationship: negatively_regulates GO:0031589 ! cell-substrate adhesion

[Term]
id: GO:0010813
name: neuropeptide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of neuropeptides. Neuropeptides are signaling peptides that travel across a synaptic junction." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0043171 ! peptide catabolic process

[Term]
id: GO:0010814
name: substance P catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the neuropeptide substance P." [GOC:BHF, GOC:rl]
is_a: GO:0010813 ! neuropeptide catabolic process

[Term]
id: GO:0010815
name: bradykinin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin." [GOC:BHF, GOC:rl]
is_a: GO:0043171 ! peptide catabolic process

[Term]
id: GO:0010816
name: calcitonin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin." [GOC:BHF, GOC:rl]
is_a: GO:0034754 ! cellular hormone metabolic process
is_a: GO:0042447 ! hormone catabolic process
is_a: GO:0043171 ! peptide catabolic process

[Term]
id: GO:0010817
name: regulation of hormone levels
namespace: biological_process
def: "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0010818
name: T cell chemotaxis
namespace: biological_process
def: "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:dph, GOC:tb]
is_a: GO:0048247 ! lymphocyte chemotaxis

[Term]
id: GO:0010819
name: regulation of T cell chemotaxis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:dph, GOC:tb]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
relationship: regulates GO:0010818 ! T cell chemotaxis

[Term]
id: GO:0010820
name: positive regulation of T cell chemotaxis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0010819 ! regulation of T cell chemotaxis
relationship: positively_regulates GO:0010818 ! T cell chemotaxis

[Term]
id: GO:0010821
name: regulation of mitochondrion organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0007005 ! mitochondrion organization

[Term]
id: GO:0010822
name: positive regulation of mitochondrion organization
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0010821 ! regulation of mitochondrion organization
relationship: positively_regulates GO:0007005 ! mitochondrion organization

[Term]
id: GO:0010823
name: negative regulation of mitochondrion organization
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0010821 ! regulation of mitochondrion organization
relationship: negatively_regulates GO:0007005 ! mitochondrion organization

[Term]
id: GO:0010824
name: regulation of centrosome duplication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]
is_a: GO:0046605 ! regulation of centrosome cycle
relationship: regulates GO:0051298 ! centrosome duplication

[Term]
id: GO:0010825
name: positive regulation of centrosome duplication
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0010824 ! regulation of centrosome duplication
relationship: positively_regulates GO:0051298 ! centrosome duplication

[Term]
id: GO:0010826
name: negative regulation of centrosome duplication
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0010824 ! regulation of centrosome duplication
relationship: negatively_regulates GO:0051298 ! centrosome duplication

[Term]
id: GO:0010827
name: regulation of glucose transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0015758 ! glucose transport

[Term]
id: GO:0010828
name: positive regulation of glucose transport
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010827 ! regulation of glucose transport
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0015758 ! glucose transport

[Term]
id: GO:0010829
name: negative regulation of glucose transport
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010827 ! regulation of glucose transport
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0015758 ! glucose transport

[Term]
id: GO:0010830
name: regulation of myotube differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process whereby a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]
is_a: GO:0048742 ! regulation of skeletal muscle fiber development
is_a: GO:0051147 ! regulation of muscle cell differentiation
relationship: regulates GO:0014902 ! myotube differentiation

[Term]
id: GO:0010831
name: positive regulation of myotube differentiation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process whereby a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:0051149 ! positive regulation of muscle cell differentiation
relationship: positively_regulates GO:0014902 ! myotube differentiation

[Term]
id: GO:0010832
name: negative regulation of myotube differentiation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process whereby a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb]
is_a: GO:0010830 ! regulation of myotube differentiation
is_a: GO:0051148 ! negative regulation of muscle cell differentiation
relationship: negatively_regulates GO:0014902 ! myotube differentiation

[Term]
id: GO:0010833
name: telomere maintenance via telomere lengthening
namespace: biological_process
def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb]
is_a: GO:0000723 ! telomere maintenance

[Term]
id: GO:0010834
name: telomere maintenance via telomere shortening
namespace: biological_process
def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and shortening the telomeric DNA." [GOC:dph, GOC:tb]
is_a: GO:0000723 ! telomere maintenance

[Term]
id: GO:0010835
name: regulation of protein amino acid ADP-ribosylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein amino acid ADP-ribosylation. Protein amino acid ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:dph, GOC:tb]
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0006471 ! protein amino acid ADP-ribosylation

[Term]
id: GO:0010836
name: negative regulation of protein amino acid ADP-ribosylation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of protein amino acid ADP-ribosylation. Protein amino acid ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010835 ! regulation of protein amino acid ADP-ribosylation
is_a: GO:0031400 ! negative regulation of protein modification process
relationship: negatively_regulates GO:0006471 ! protein amino acid ADP-ribosylation

[Term]
id: GO:0010837
name: regulation of keratinocyte proliferation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb]
is_a: GO:0042127 ! regulation of cell proliferation
relationship: regulates GO:0043616 ! keratinocyte proliferation

[Term]
id: GO:0010838
name: positive regulation of keratinocyte proliferation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0010837 ! regulation of keratinocyte proliferation
relationship: positively_regulates GO:0043616 ! keratinocyte proliferation

[Term]
id: GO:0010839
name: negative regulation of keratinocyte proliferation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0010837 ! regulation of keratinocyte proliferation
relationship: negatively_regulates GO:0043616 ! keratinocyte proliferation

[Term]
id: GO:0010840
name: regulation of circadian sleep/wake cycle, wakefulness
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:dph, GOC:tb]
is_a: GO:0042749 ! regulation of circadian sleep/wake cycle
relationship: regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness

[Term]
id: GO:0010841
name: positive regulation of circadian sleep/wake cycle, wakefulness
namespace: biological_process
def: "Any process that increases the frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010840 ! regulation of circadian sleep/wake cycle, wakefulness
is_a: GO:0042753 ! positive regulation of circadian rhythm
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness

[Term]
id: GO:0010842
name: retina layer formation
namespace: biological_process
def: "The process whereby the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:1270266]
synonym: "retinal lamination" EXACT [GOC:dph, GOC:tb]
synonym: "retinal layer formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003407 ! neural retina development
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye

[Term]
id: GO:0010843
name: promoter binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factor complexes of the basal transcription machinery." [GOC:dph, GOC:tb, SO:0000167]
synonym: "DNA binding, transcription promoter" EXACT [GOC:dph, GOC:tb]
is_a: GO:0043565 ! sequence-specific DNA binding
is_a: GO:0044212 ! DNA regulatory region binding

[Term]
id: GO:0010844
name: recombination hotspot binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a region in a genome which promotes recombination." [GOC:dph, GOC:tb]
synonym: "DNA binding, recombination hotspot" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0010845
name: positive regulation of reciprocal meiotic recombination
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
synonym: "positive regulation of meiotic recombination" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010520 ! regulation of reciprocal meiotic recombination
is_a: GO:0045836 ! positive regulation of meiosis
is_a: GO:0045911 ! positive regulation of DNA recombination
relationship: positively_regulates GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0010846
name: activation of reciprocal meiotic recombination
namespace: biological_process
def: "Any process that starts the inactive process of reciprocal meiotic recombination. Reciprocal meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb]
synonym: "activation of meiotic recombination" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010845 ! positive regulation of reciprocal meiotic recombination

[Term]
id: GO:0010847
name: regulation of chromatin assembly
namespace: biological_process
def: "Any process the modulates the frequency, rate or extent of chromatin assembly. Chromatin assembly is the assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [GOC:dph, GOC:tb]
is_a: GO:0001672 ! regulation of chromatin assembly or disassembly
is_a: GO:0044087 ! regulation of cellular component biogenesis
relationship: regulates GO:0031497 ! chromatin assembly

[Term]
id: GO:0010848
name: regulation of chromatin disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromatin disassembly. Chromatin disassembly is the controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, and other proteins." [GOC:dph, GOC:tb]
is_a: GO:0001672 ! regulation of chromatin assembly or disassembly
relationship: regulates GO:0031498 ! chromatin disassembly

[Term]
id: GO:0010849
name: regulation of proton-transporting ATPase activity, rotational mechanism
namespace: biological_process
def: "Any process that modulates the rate of ATP hydrolysis by an ATPase. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [GOC:dph, GOC:tb]
synonym: "regulation of hydrogen ion transporting ATPase activity, rotational mechanism" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of V-type ATPase activity" BROAD [GOC:dph, GOC:tb]
is_a: GO:0010155 ! regulation of proton transport
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:0043462 ! regulation of ATPase activity

[Term]
id: GO:0010850
name: chemoreceptor signaling pathway involved in regulation of blood pressure
namespace: biological_process
def: "A series of reactions within the cell that occur as a result of a single trigger reaction or compound interacting with a chemoreceptor resulting in a modulation of the force with which blood travels through the circulatory system. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb]
synonym: "chemoreceptor signalling pathway involved in regulation of blood pressure" EXACT [GOC:mah]
is_a: GO:0007242 ! intracellular signaling cascade
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0010851
name: cyclase regulator activity
namespace: molecular_function
def: "Modulates the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0010852
name: cyclase inhibitor activity
namespace: molecular_function
def: "Decreases the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb]
is_a: GO:0010851 ! cyclase regulator activity

[Term]
id: GO:0010853
name: cyclase activator activity
namespace: molecular_function
def: "Increases the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb]
is_a: GO:0010851 ! cyclase regulator activity

[Term]
id: GO:0010854
name: adenylate cyclase regulator activity
namespace: molecular_function
def: "Modulates the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb]
is_a: GO:0010851 ! cyclase regulator activity

[Term]
id: GO:0010855
name: adenylate cyclase inhibitor activity
namespace: molecular_function
def: "Decreases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb]
is_a: GO:0010854 ! adenylate cyclase regulator activity

[Term]
id: GO:0010856
name: adenylate cyclase activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb]
is_a: GO:0010854 ! adenylate cyclase regulator activity

[Term]
id: GO:0010857
name: calcium-dependent protein kinase activity
namespace: molecular_function
def: "Catalysis of the calcium-dependent phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:dph, GOC:tb]
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0010858
name: calcium-dependent protein kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner." [GOC:dph, GOC:tb]
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0010859
name: calcium-dependent cysteine-type endopeptidase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner." [GOC:dph, GOC:tb]
is_a: GO:0004869 ! cysteine-type endopeptidase inhibitor activity

[Term]
id: GO:0010860
name: proteasome regulator activity
namespace: molecular_function
def: "Modulates the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:dph, GOC:tb]
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0010861
name: thyroid hormone receptor activator activity
namespace: molecular_function
def: "Any transcription regulator activity required for initiation or upregulation of transcription." [GOC:dph, GOC:tb]
is_a: GO:0030546 ! receptor activator activity

[Term]
id: GO:0010862
name: positive regulation of pathway-restricted SMAD protein phosphorylation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of SMAD protein nuclear translocation. SMAD protein nuclear translocation is the vectorial transfer of a SMAD proteins from the cytoplasm into the nucleus, through the nuclear pore. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph, GOC:tb]
is_a: GO:0001934 ! positive regulation of protein amino acid phosphorylation
is_a: GO:0060393 ! regulation of pathway-restricted SMAD protein phosphorylation
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: positively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation

[Term]
id: GO:0010863
name: positive regulation of phospholipase C activity
namespace: biological_process
def: "Any process that increases the rate of phospholipase C activity." [GOC:dph, GOC:tb]
is_a: GO:0010518 ! positive regulation of phospholipase activity

[Term]
id: GO:0010864
name: positive regulation of protein histidine kinase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of protein histidine kinase activity." [GOC:dph, GOC:tb]
is_a: GO:0032110 ! regulation of protein histidine kinase activity
is_a: GO:0045860 ! positive regulation of protein kinase activity

[Term]
id: GO:0010865
name: stipule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stipule over time, from its formation to the mature structure. A stipule is one of (usually) a pair of appendages at the bases of leaves in many broad-leaved angiosperms." [GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048366 ! leaf development

[Term]
id: GO:0010866
name: regulation of triglyceride biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb]
synonym: "regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
is_a: GO:0090207 ! regulation of triglyceride metabolic process
relationship: regulates GO:0019432 ! triglyceride biosynthetic process

[Term]
id: GO:0010867
name: positive regulation of triglyceride biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb]
synonym: "positive regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah]
is_a: GO:0010866 ! regulation of triglyceride biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0090208 ! positive regulation of triglyceride metabolic process
relationship: positively_regulates GO:0019432 ! triglyceride biosynthetic process

[Term]
id: GO:0010868
name: negative regulation of triglyceride biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb]
synonym: "negative regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah]
is_a: GO:0010866 ! regulation of triglyceride biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:0090209 ! negative regulation of triglyceride metabolic process
relationship: negatively_regulates GO:0019432 ! triglyceride biosynthetic process

[Term]
id: GO:0010869
name: regulation of receptor biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0031323 ! regulation of cellular metabolic process
relationship: regulates GO:0032800 ! receptor biosynthetic process

[Term]
id: GO:0010870
name: positive regulation of receptor biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0010869 ! regulation of receptor biosynthetic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
relationship: positively_regulates GO:0032800 ! receptor biosynthetic process

[Term]
id: GO:0010871
name: negative regulation of receptor biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0010869 ! regulation of receptor biosynthetic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
relationship: negatively_regulates GO:0032800 ! receptor biosynthetic process

[Term]
id: GO:0010872
name: regulation of cholesterol esterification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:dph, GOC:tb]
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
relationship: regulates GO:0034435 ! cholesterol esterification

[Term]
id: GO:0010873
name: positive regulation of cholesterol esterification
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010872 ! regulation of cholesterol esterification
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0045940 ! positive regulation of steroid metabolic process
relationship: positively_regulates GO:0034435 ! cholesterol esterification

[Term]
id: GO:0010874
name: regulation of cholesterol efflux
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032374 ! regulation of cholesterol transport
relationship: regulates GO:0033344 ! cholesterol efflux

[Term]
id: GO:0010875
name: positive regulation of cholesterol efflux
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010874 ! regulation of cholesterol efflux
is_a: GO:0032376 ! positive regulation of cholesterol transport
relationship: positively_regulates GO:0033344 ! cholesterol efflux

[Term]
id: GO:0010876
name: lipid localization
namespace: biological_process
def: "Any process by which a lipid is transported to, or maintained in, a specific location." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0033036 ! macromolecule localization

[Term]
id: GO:0010877
name: lipid transport involved in lipid storage
namespace: biological_process
def: "The directed movement of lipids into cells that is part of their accumulation and maintenance." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0006869 ! lipid transport
relationship: part_of GO:0019915 ! lipid storage

[Term]
id: GO:0010878
name: cholesterol storage
namespace: biological_process
def: "The accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "cholesterol sequestration" NARROW [GOC:dph, GOC:tb]
synonym: "sequestration of cholesterol" NARROW [GOC:dph, GOC:tb]
is_a: GO:0019915 ! lipid storage

[Term]
id: GO:0010879
name: cholesterol transport involved in cholesterol storage
namespace: biological_process
def: "The directed movement of cholesterol into cells that is part of their accumulation and maintenance." [GOC:dph, GOC:tb]
synonym: "sequestration of cholesterol" NARROW [GOC:dph, GOC:tb]
is_a: GO:0010877 ! lipid transport involved in lipid storage
is_a: GO:0030301 ! cholesterol transport
relationship: part_of GO:0010878 ! cholesterol storage

[Term]
id: GO:0010880
name: regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process whereby the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol
relationship: regulates GO:0014808 ! release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

[Term]
id: GO:0010881
name: regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010880 ! regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
is_a: GO:0010882 ! regulation of cardiac muscle contraction by calcium ion signaling

[Term]
id: GO:0010882
name: regulation of cardiac muscle contraction by calcium ion signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of cardiac muscle contraction by calcium ion signalling" EXACT [GOC:mah]
is_a: GO:0055117 ! regulation of cardiac muscle contraction

[Term]
id: GO:0010883
name: regulation of lipid storage
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of lipid sequestration" NARROW [GOC:dph, GOC:tb]
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0019915 ! lipid storage

[Term]
id: GO:0010884
name: positive regulation of lipid storage
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of lipid sequestration" NARROW [GOC:dph, GOC:tb]
is_a: GO:0010883 ! regulation of lipid storage
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0019915 ! lipid storage

[Term]
id: GO:0010885
name: regulation of cholesterol storage
namespace: biological_process
def: "Any process that modulates the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010883 ! regulation of lipid storage
relationship: regulates GO:0010878 ! cholesterol storage

[Term]
id: GO:0010886
name: positive regulation of cholesterol storage
namespace: biological_process
def: "Any process that increases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of cholesterol sequestration" NARROW [GOC:dph, GOC:tb]
is_a: GO:0010884 ! positive regulation of lipid storage
is_a: GO:0010885 ! regulation of cholesterol storage
relationship: positively_regulates GO:0010878 ! cholesterol storage

[Term]
id: GO:0010887
name: negative regulation of cholesterol storage
namespace: biological_process
def: "Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of cholesterol sequestration" NARROW [GOC:dph, GOC:tb]
is_a: GO:0010885 ! regulation of cholesterol storage
is_a: GO:0010888 ! negative regulation of lipid storage
relationship: negatively_regulates GO:0010878 ! cholesterol storage

[Term]
id: GO:0010888
name: negative regulation of lipid storage
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010883 ! regulation of lipid storage
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0019915 ! lipid storage

[Term]
id: GO:0010889
name: regulation of sequestering of triglyceride
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of sequestering of triacylglycerol" EXACT [GOC:mah]
synonym: "regulation of triacylglycerol sequestration" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010883 ! regulation of lipid storage
relationship: regulates GO:0030730 ! sequestering of triglyceride

[Term]
id: GO:0010890
name: positive regulation of sequestering of triglyceride
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of sequestering of triacylglycerol" EXACT [GOC:mah]
synonym: "positive regulation of triglyceride sequestration" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010884 ! positive regulation of lipid storage
is_a: GO:0010889 ! regulation of sequestering of triglyceride
relationship: positively_regulates GO:0030730 ! sequestering of triglyceride

[Term]
id: GO:0010891
name: negative regulation of sequestering of triglyceride
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of sequestering of triacylglycerol" EXACT [GOC:mah]
synonym: "negative regulation of triglyceride sequestration" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010888 ! negative regulation of lipid storage
is_a: GO:0010889 ! regulation of sequestering of triglyceride
relationship: negatively_regulates GO:0030730 ! sequestering of triglyceride

[Term]
id: GO:0010892
name: positive regulation of mitochondrial translation in response to stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress." [GOC:dph, GOC:jp, GOC:tb, PMID:8830768]
is_a: GO:0032056 ! positive regulation of translation in response to stress
is_a: GO:0070131 ! positive regulation of mitochondrial translation

[Term]
id: GO:0010893
name: positive regulation of steroid biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:tb]
is_a: GO:0045940 ! positive regulation of steroid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
relationship: positively_regulates GO:0006694 ! steroid biosynthetic process

[Term]
id: GO:0010894
name: negative regulation of steroid biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:BHF, GOC:tb]
is_a: GO:0045939 ! negative regulation of steroid metabolic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
relationship: negatively_regulates GO:0006694 ! steroid biosynthetic process

[Term]
id: GO:0010895
name: negative regulation of ergosterol biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:tb]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0032443 ! regulation of ergosterol biosynthetic process
relationship: negatively_regulates GO:0006696 ! ergosterol biosynthetic process

[Term]
id: GO:0010896
name: regulation of triglyceride catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb]
synonym: "regulation of triacylglycerol catabolic process" EXACT [GOC:mah]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
is_a: GO:0090207 ! regulation of triglyceride metabolic process
relationship: regulates GO:0019433 ! triglyceride catabolic process

[Term]
id: GO:0010897
name: negative regulation of triglyceride catabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb]
synonym: "negative regulation of triacylglycerol catabolic process" EXACT [GOC:mah]
is_a: GO:0010896 ! regulation of triglyceride catabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
is_a: GO:0090209 ! negative regulation of triglyceride metabolic process
relationship: negatively_regulates GO:0019433 ! triglyceride catabolic process

[Term]
id: GO:0010898
name: positive regulation of triglyceride catabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb]
synonym: "positive regulation of triacylglycerol catabolic process" EXACT [GOC:mah]
is_a: GO:0010896 ! regulation of triglyceride catabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:0090208 ! positive regulation of triglyceride metabolic process
relationship: positively_regulates GO:0019433 ! triglyceride catabolic process

[Term]
id: GO:0010899
name: regulation of phosphatidylcholine catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:BHF, GOC:tb]
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0060696 ! regulation of phospholipid catabolic process
relationship: regulates GO:0034638 ! phosphatidylcholine catabolic process

[Term]
id: GO:0010900
name: negative regulation of phosphatidylcholine catabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:BHF, GOC:tb]
is_a: GO:0010899 ! regulation of phosphatidylcholine catabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0033239 ! negative regulation of cellular amine metabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
relationship: negatively_regulates GO:0034638 ! phosphatidylcholine catabolic process

[Term]
id: GO:0010901
name: regulation of very-low-density lipoprotein particle remodeling
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb]
synonym: "regulation of VLDL remodeling" EXACT [GOC:tb]
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0034372 ! very-low-density lipoprotein particle remodeling

[Term]
id: GO:0010902
name: positive regulation of very-low-density lipoprotein particle remodeling
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb]
synonym: "positive regulation of VLDL remodeling" EXACT [GOC:tb]
is_a: GO:0010901 ! regulation of very-low-density lipoprotein particle remodeling
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling

[Term]
id: GO:0010903
name: negative regulation of very-low-density lipoprotein particle remodeling
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb]
synonym: "negative regulation of VLDL remodeling" EXACT [GOC:tb]
is_a: GO:0010901 ! regulation of very-low-density lipoprotein particle remodeling
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling

[Term]
id: GO:0010904
name: regulation of UDP-glucose catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:BHF, GOC:tb]
synonym: "regulation of UDP-glucose catabolism" EXACT [GOC:tb]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
relationship: regulates GO:0006258 ! UDP-glucose catabolic process

[Term]
id: GO:0010905
name: negative regulation of UDP-glucose catabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:BHF, GOC:tb]
synonym: "negative regulation of UDP-glucose catabolism" EXACT [GOC:tb]
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0010904 ! regulation of UDP-glucose catabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
relationship: negatively_regulates GO:0006258 ! UDP-glucose catabolic process

[Term]
id: GO:0010906
name: regulation of glucose metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]
synonym: "regulation of glucose metabolism" EXACT [GOC:tb]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
relationship: regulates GO:0006006 ! glucose metabolic process

[Term]
id: GO:0010907
name: positive regulation of glucose metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb]
synonym: "positive regulation of glucose metabolism" EXACT [GOC:tb]
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0010906 ! regulation of glucose metabolic process
relationship: positively_regulates GO:0006006 ! glucose metabolic process

[Term]
id: GO:0010908
name: regulation of heparan sulfate proteoglycan biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues." [GOC:dph, GOC:tb]
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
relationship: regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0010909
name: positive regulation of heparan sulfate proteoglycan biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues." [GOC:dph, GOC:tb]
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0010908 ! regulation of heparan sulfate proteoglycan biosynthetic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
relationship: positively_regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0010910
name: positive regulation of heparan sulfate proteoglycan biosynthesis by positive regulation of epimerase activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis by an increase in epimerase activity. This epimerase activity catalyzes the reaction that converts D-glucuronate into its diastereoisomer in heparan sulfate." [GOC:dph, GOC:tb]
is_a: GO:0010909 ! positive regulation of heparan sulfate proteoglycan biosynthetic process
is_a: GO:0010912 ! positive regulation of isomerase activity

[Term]
id: GO:0010911
name: regulation of isomerase activity
namespace: biological_process
def: "Any process that modulates the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [GOC:dph, GOC:tb]
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0010912
name: positive regulation of isomerase activity
namespace: biological_process
def: "Any process that increases the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [GOC:dph, GOC:tb]
is_a: GO:0010911 ! regulation of isomerase activity
is_a: GO:0043085 ! positive regulation of catalytic activity

[Term]
id: GO:0010913
name: regulation of sterigmatocystin biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:dph, GOC:tb]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043455 ! regulation of secondary metabolic process
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0045461 ! sterigmatocystin biosynthetic process

[Term]
id: GO:0010914
name: positive regulation of sterigmatocystin biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:dph, GOC:tb]
is_a: GO:0010913 ! regulation of sterigmatocystin biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0045461 ! sterigmatocystin biosynthetic process

[Term]
id: GO:0010915
name: regulation of very-low-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process by which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of VLDL clearance" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of VLDL particle clearance" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
relationship: regulates GO:0034447 ! very-low-density lipoprotein particle clearance

[Term]
id: GO:0010916
name: negative regulation of very-low-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process by which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "negative regulation of VLDL clearance" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of VLDL particle clearance" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010915 ! regulation of very-low-density lipoprotein particle clearance
is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance
relationship: negatively_regulates GO:0034447 ! very-low-density lipoprotein particle clearance

[Term]
id: GO:0010917
name: negative regulation of mitochondrial membrane potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb]
is_a: GO:0045837 ! negative regulation of membrane potential
is_a: GO:0051881 ! regulation of mitochondrial membrane potential

[Term]
id: GO:0010918
name: positive regulation of mitochondrial membrane potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb]
is_a: GO:0045838 ! positive regulation of membrane potential
is_a: GO:0051881 ! regulation of mitochondrial membrane potential

[Term]
id: GO:0010919
name: regulation of inositol phosphate biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of inositol phosphate biosynthesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
relationship: regulates GO:0032958 ! inositol phosphate biosynthetic process

[Term]
id: GO:0010920
name: negative regulation of inositol phosphate biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:dph, GOC:tb]
synonym: "negative regulation of inositol phosphate biosynthesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
relationship: negatively_regulates GO:0032958 ! inositol phosphate biosynthetic process

[Term]
id: GO:0010921
name: regulation of phosphatase activity
namespace: biological_process
def: "Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0035303 ! regulation of dephosphorylation
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0010922
name: positive regulation of phosphatase activity
namespace: biological_process
def: "Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010921 ! regulation of phosphatase activity
is_a: GO:0051345 ! positive regulation of hydrolase activity

[Term]
id: GO:0010923
name: negative regulation of phosphatase activity
namespace: biological_process
def: "Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010921 ! regulation of phosphatase activity
is_a: GO:0051346 ! negative regulation of hydrolase activity

[Term]
id: GO:0010924
name: regulation of inositol-polyphosphate 5-phosphatase activity
namespace: biological_process
def: "Any process that modulates the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010921 ! regulation of phosphatase activity

[Term]
id: GO:0010925
name: positive regulation of inositol-polyphosphate 5-phosphatase activity
namespace: biological_process
def: "Any process that increases the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010922 ! positive regulation of phosphatase activity
is_a: GO:0010924 ! regulation of inositol-polyphosphate 5-phosphatase activity

[Term]
id: GO:0010926
name: anatomical structure formation
namespace: biological_process
def: "OBSOLETE. The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structure is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:tb]
comment: The reason for obsoletion is that the term is confusing - it sounds developmental and has a developmental sounding def, but it is not a child of developmental process and its children included 'cellular component assembly'. The term was created to group together 'cellular component assembly' and 'anatomical structure formation involved in morphogenesis', but we no longer feel that this grouping is useful.
is_obsolete: true
consider: GO:0022607
consider: GO:0048646

[Term]
id: GO:0010927
name: cellular component assembly involved in morphogenesis
namespace: biological_process
def: "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0032989 ! cellular component morphogenesis

[Term]
id: GO:0010928
name: regulation of auxin mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0009734 ! auxin mediated signaling pathway

[Term]
id: GO:0010929
name: positive regulation of auxin mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0010928 ! regulation of auxin mediated signaling pathway
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0009734 ! auxin mediated signaling pathway

[Term]
id: GO:0010930
name: negative regulation of auxin mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0010928 ! regulation of auxin mediated signaling pathway
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0009734 ! auxin mediated signaling pathway

[Term]
id: GO:0010931
name: macrophage tolerance induction
namespace: biological_process
def: "A process involving any mechanism for tolerance induction in macrophages." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002507 ! tolerance induction

[Term]
id: GO:0010932
name: regulation of macrophage tolerance induction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of B cell tolerance induction." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002643 ! regulation of tolerance induction
relationship: regulates GO:0010931 ! macrophage tolerance induction

[Term]
id: GO:0010933
name: positive regulation of macrophage tolerance induction
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of B cell tolerance induction." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002645 ! positive regulation of tolerance induction
is_a: GO:0010932 ! regulation of macrophage tolerance induction
relationship: positively_regulates GO:0010931 ! macrophage tolerance induction

[Term]
id: GO:0010934
name: macrophage cytokine production
namespace: biological_process
def: "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl]
xref: GOC:dph
xref: GOC:tb
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0010935
name: regulation of macrophage cytokine production
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0010934 ! macrophage cytokine production

[Term]
id: GO:0010936
name: negative regulation of macrophage cytokine production
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0010935 ! regulation of macrophage cytokine production
relationship: negatively_regulates GO:0010934 ! macrophage cytokine production

[Term]
id: GO:0010937
name: regulation of cytoplasmic microtubule depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization." [GOC:dph, GOC:tb]
is_a: GO:0031114 ! regulation of microtubule depolymerization
relationship: regulates GO:0010938 ! cytoplasmic microtubule depolymerization

[Term]
id: GO:0010938
name: cytoplasmic microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule." [GOC:dph, GOC:tb]
is_a: GO:0007019 ! microtubule depolymerization
is_a: GO:0031122 ! cytoplasmic microtubule organization

[Term]
id: GO:0010939
name: regulation of necrotic cell death
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [PMID:16507998]
is_a: GO:0010941 ! regulation of cell death
relationship: regulates GO:0070265 ! necrotic cell death

[Term]
id: GO:0010940
name: positive regulation of necrotic cell death
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [PMID:16507998]
is_a: GO:0010939 ! regulation of necrotic cell death
is_a: GO:0010942 ! positive regulation of cell death
relationship: positively_regulates GO:0070265 ! necrotic cell death

[Term]
id: GO:0010941
name: regulation of cell death
namespace: biological_process
def: "Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0008219 ! cell death

[Term]
id: GO:0010942
name: positive regulation of cell death
namespace: biological_process
def: "Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb]
is_a: GO:0010941 ! regulation of cell death
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0008219 ! cell death

[Term]
id: GO:0010943
name: NADPH pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H20 = NMNH + ADP." [GOC:tb]
is_a: GO:0004551 ! nucleotide diphosphatase activity

[Term]
id: GO:0010944
name: negative regulation of transcription by competitive promoter binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site." [GOC:tb]
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent

[Term]
id: GO:0010945
name: CoA pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: coenzyme A + H20 = 3',5'-ADP + 4'-phosphopantetheine." [GOC:tb]
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0010946
name: regulation of meiotic joint molecule formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination." [GOC:dph, GOC:tb]
is_a: GO:0010520 ! regulation of reciprocal meiotic recombination
relationship: regulates GO:0000709 ! meiotic joint molecule formation

[Term]
id: GO:0010947
name: negative regulation of meiotic joint molecule formation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination." [GOC:dph, GOC:tb]
is_a: GO:0010946 ! regulation of meiotic joint molecule formation
is_a: GO:0010948 ! negative regulation of cell cycle process
relationship: negatively_regulates GO:0000709 ! meiotic joint molecule formation

[Term]
id: GO:0010948
name: negative regulation of cell cycle process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0022402 ! cell cycle process

[Term]
id: GO:0010949
name: negative regulation of intestinal phytosterol absorption
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of phytosterols into the blood by absorption from the small intestine." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032372 ! negative regulation of sterol transport
is_a: GO:0060457 ! negative regulation of digestive system process
relationship: negatively_regulates GO:0060752 ! intestinal phytosterol absorption

[Term]
id: GO:0010950
name: positive regulation of endopeptidase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
is_a: GO:0010952 ! positive regulation of peptidase activity
is_a: GO:0052548 ! regulation of endopeptidase activity

[Term]
id: GO:0010951
name: negative regulation of endopeptidase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
is_a: GO:0010466 ! negative regulation of peptidase activity
is_a: GO:0052548 ! regulation of endopeptidase activity

[Term]
id: GO:0010952
name: positive regulation of peptidase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb]
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:0052547 ! regulation of peptidase activity

[Term]
id: GO:0010953
name: regulation of protein maturation by peptide bond cleavage
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:0070613 ! regulation of protein processing
relationship: regulates GO:0051605 ! protein maturation by peptide bond cleavage

[Term]
id: GO:0010954
name: positive regulation of protein maturation by peptide bond cleavage
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0010953 ! regulation of protein maturation by peptide bond cleavage
is_a: GO:0045862 ! positive regulation of proteolysis
relationship: positively_regulates GO:0051605 ! protein maturation by peptide bond cleavage

[Term]
id: GO:0010955
name: negative regulation of protein maturation by peptide bond cleavage
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0010953 ! regulation of protein maturation by peptide bond cleavage
is_a: GO:0045861 ! negative regulation of proteolysis
relationship: negatively_regulates GO:0051605 ! protein maturation by peptide bond cleavage

[Term]
id: GO:0010956
name: negative regulation of calcidiol 1-monooxygenase activity
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032769 ! negative regulation of monooxygenase activity
is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity

[Term]
id: GO:0010957
name: negative regulation of vitamin D biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
is_a: GO:0060556 ! regulation of vitamin D biosynthetic process
relationship: negatively_regulates GO:0042368 ! vitamin D biosynthetic process

[Term]
id: GO:0010958
name: regulation of amino acid import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amino acid import. Amino acid import is the directed movement of amino acids into a cell or organelle." [GOC:dph, GOC:tb]
is_a: GO:0051955 ! regulation of amino acid transport
relationship: regulates GO:0043090 ! amino acid import

[Term]
id: GO:0010959
name: regulation of metal ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0043269 ! regulation of ion transport
relationship: regulates GO:0030001 ! metal ion transport

[Term]
id: GO:0010960
name: magnesium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of magnesium ions within an organism or cell." [GOC:dph, GOC:tb]
is_a: GO:0055065 ! metal ion homeostasis
is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis

[Term]
id: GO:0010961
name: cellular magnesium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of magnesium ions at the level of a cell." [GOC:dph, GOC:tb]
is_a: GO:0006875 ! cellular metal ion homeostasis
is_a: GO:0010960 ! magnesium ion homeostasis
is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis

[Term]
id: GO:0010962
name: regulation of glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:dph, GOC:tb]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
relationship: regulates GO:0009250 ! glucan biosynthetic process

[Term]
id: GO:0010963
name: regulation of L-arginine import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of L-arginine import. L-arginine import is the directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle." [GOC:dph, GOC:tb]
is_a: GO:0010958 ! regulation of amino acid import
relationship: regulates GO:0043091 ! L-arginine import

[Term]
id: GO:0010964
name: regulation of chromatin silencing by small RNA
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromatin silencing by small RNA. Chromatin silencing by small RNA is the repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:tb]
is_a: GO:0031935 ! regulation of chromatin silencing
is_a: GO:0060966 ! regulation of gene silencing by RNA
relationship: regulates GO:0031048 ! chromatin silencing by small RNA

[Term]
id: GO:0010965
name: regulation of mitotic sister chromatid separation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process by which sister chromatids are physically detached from each other during mitosis." [GOC:dph, GOC:tb]
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
relationship: regulates GO:0051306 ! mitotic sister chromatid separation

[Term]
id: GO:0010966
name: regulation of phosphate transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0044070 ! regulation of anion transport
relationship: regulates GO:0006817 ! phosphate transport

[Term]
id: GO:0010967
name: regulation of polyamine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of polyamine biosynthesis. Polyamine biosynthesis is the chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [GOC:dph, GOC:tb]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0006596 ! polyamine biosynthetic process

[Term]
id: GO:0010968
name: regulation of microtubule nucleation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
relationship: regulates GO:0007020 ! microtubule nucleation

[Term]
id: GO:0010969
name: regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion
relationship: regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion

[Term]
id: GO:0010970
name: microtubule-based transport
namespace: biological_process
def: "The directed movement of organelles and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb]
is_a: GO:0007018 ! microtubule-based movement
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport

[Term]
id: GO:0010971
name: positive regulation of G2/M transition of mitotic cell cycle
namespace: biological_process
def: "Any process that increases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:tb]
synonym: "positive regulation of mitotic entry" EXACT [GOC:mah]
is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle

[Term]
id: GO:0010972
name: negative regulation of G2/M transition of mitotic cell cycle
namespace: biological_process
def: "Any process that decreases the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:tb]
synonym: "negative regulation of mitotic entry" EXACT [GOC:vw]
is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
relationship: negatively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle

[Term]
id: GO:0010973
name: positive regulation of barrier septum formation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of barrier septum formation. Barrier septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:dph, GOC:tb]
is_a: GO:0032467 ! positive regulation of cytokinesis
is_a: GO:0032955 ! regulation of barrier septum formation
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0000917 ! barrier septum formation

[Term]
id: GO:0010974
name: negative regulation of barrier septum formation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of barrier septum formation. Barrier septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:dph, GOC:tb]
is_a: GO:0032466 ! negative regulation of cytokinesis
is_a: GO:0032955 ! regulation of barrier septum formation
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0000917 ! barrier septum formation

[Term]
id: GO:0010975
name: regulation of neuron projection development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]
synonym: "regulation of neurite biosynthesis" NARROW [GOC:mah]
synonym: "regulation of neurite development" NARROW [GOC:mah]
synonym: "regulation of neurite formation" NARROW [GOC:mah]
synonym: "regulation of neurite growth" NARROW [GOC:mah]
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0045664 ! regulation of neuron differentiation
relationship: regulates GO:0031175 ! neuron projection development

[Term]
id: GO:0010976
name: positive regulation of neuron projection development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]
synonym: "positive regulation of neurite biosynthesis" NARROW [GOC:mah]
synonym: "positive regulation of neurite development" NARROW [GOC:mah]
synonym: "positive regulation of neurite formation" NARROW [GOC:mah]
synonym: "positive regulation of neurite growth" NARROW [GOC:mah]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0031346 ! positive regulation of cell projection organization
relationship: positively_regulates GO:0031175 ! neuron projection development

[Term]
id: GO:0010977
name: negative regulation of neuron projection development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb]
synonym: "negative regulation of neurite biosynthesis" NARROW [GOC:mah]
synonym: "negative regulation of neurite development" NARROW [GOC:mah]
synonym: "negative regulation of neurite formation" NARROW [GOC:mah]
synonym: "negative regulation of neurite growth" NARROW [GOC:mah]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0031345 ! negative regulation of cell projection organization
relationship: negatively_regulates GO:0031175 ! neuron projection development

[Term]
id: GO:0010978
name: gene silencing involved in chronological cell aging
namespace: biological_process
def: "Any transcriptional or post-transcriptional process, arising in non-dividing cells as they age, carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:jp, GOC:tb]
is_a: GO:0016458 ! gene silencing
relationship: part_of GO:0001300 ! chronological cell aging

[Term]
id: GO:0010979
name: regulation of vitamin D 24-hydroxylase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:0010980
name: positive regulation of vitamin D 24-hydroxylase activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010979 ! regulation of vitamin D 24-hydroxylase activity
is_a: GO:0051353 ! positive regulation of oxidoreductase activity

[Term]
id: GO:0010981
name: regulation of cell wall macromolecule metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cell wall macromolecule metabolism. Cell wall macromolecule metabolic processes are the chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:dph, GOC:tb]
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0044036 ! cell wall macromolecule metabolic process

[Term]
id: GO:0010982
name: regulation of high-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process by which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
relationship: regulates GO:0034384 ! high-density lipoprotein particle clearance

[Term]
id: GO:0010983
name: positive regulation of high-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process by which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010982 ! regulation of high-density lipoprotein particle clearance
is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance
relationship: positively_regulates GO:0034384 ! high-density lipoprotein particle clearance

[Term]
id: GO:0010984
name: regulation of lipoprotein particle clearance
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process by which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0034381 ! lipoprotein particle clearance

[Term]
id: GO:0010985
name: negative regulation of lipoprotein particle clearance
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process by which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0034381 ! lipoprotein particle clearance

[Term]
id: GO:0010986
name: positive regulation of lipoprotein particle clearance
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process by which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0034381 ! lipoprotein particle clearance

[Term]
id: GO:0010987
name: negative regulation of high-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process by which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010982 ! regulation of high-density lipoprotein particle clearance
is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance
relationship: negatively_regulates GO:0034384 ! high-density lipoprotein particle clearance

[Term]
id: GO:0010988
name: regulation of low-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process by which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010984 ! regulation of lipoprotein particle clearance
relationship: regulates GO:0034383 ! low-density lipoprotein particle clearance

[Term]
id: GO:0010989
name: negative regulation of low-density lipoprotein particle clearance
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process by which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance
is_a: GO:0010988 ! regulation of low-density lipoprotein particle clearance
relationship: negatively_regulates GO:0034383 ! low-density lipoprotein particle clearance

[Term]
id: GO:0010990
name: regulation of SMAD protein complex assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: regulates GO:0007183 ! SMAD protein complex assembly

[Term]
id: GO:0010991
name: negative regulation of SMAD protein complex assembly
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010990 ! regulation of SMAD protein complex assembly
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: negatively_regulates GO:0007183 ! SMAD protein complex assembly

[Term]
id: GO:0010992
name: ubiquitin homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of ubiquitin monomers and free ubiquitin chains at the level of the cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0019725 ! cellular homeostasis

[Term]
id: GO:0010993
name: regulation of ubiquitin homeostasis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of ubiquitin homeostasis. Ubiquitin homeostasis is any process involved in the maintenance of an internal equilibrium of ubiquitin monomers and free ubiquitin chains at the level of the cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0010992 ! ubiquitin homeostasis

[Term]
id: GO:0010994
name: free ubiquitin chain polymerization
namespace: biological_process
def: "The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051258 ! protein polymerization
relationship: part_of GO:0010993 ! regulation of ubiquitin homeostasis

[Term]
id: GO:0010995
name: free ubiquitin chain depolymerization
namespace: biological_process
def: "The process by which free ubiquitin chains, compounds composed of a large number of ubiquitin monomers, are broken down." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051261 ! protein depolymerization
relationship: part_of GO:0010993 ! regulation of ubiquitin homeostasis

[Term]
id: GO:0010996
name: response to auditory stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus." [GOC:BHF, GOC:dph, GOC:sl, GOC:tb]
synonym: "response to sound" EXACT [GOC:dph, GOC:sl, GOC:tb]
synonym: "response to sound stimulus" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009612 ! response to mechanical stimulus

[Term]
id: GO:0010997
name: anaphase-promoting complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "APC binding" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0010998
name: regulation of translational initiation by eIF2 alpha phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha." [GOC:BHF, GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0006468 ! protein amino acid phosphorylation
is_a: GO:0043558 ! regulation of translational initiation in response to stress

[Term]
id: GO:0010999
name: regulation of eIF2 alpha phosphorylation by heme
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a result of heme levels." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0001932 ! regulation of protein amino acid phosphorylation
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation

[Term]
id: GO:0011000
name: replication fork arrest at mating type locus
namespace: biological_process
def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the mating type locus." [GOC:dph, GOC:tb]
is_a: GO:0043111 ! replication fork arrest

[Term]
id: GO:0012501
name: programmed cell death
namespace: biological_process
alt_id: GO:0016244
def: "Cell death resulting from activation of endogenous cellular processes." [GOC:lr]
comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'.
synonym: "non-apoptotic programmed cell death" NARROW []
synonym: "nonapoptotic programmed cell death" NARROW []
xref: Wikipedia:Programmed_cell_death
is_a: GO:0008219 ! cell death

[Term]
id: GO:0012502
name: induction of programmed cell death
namespace: biological_process
alt_id: GO:0012503
def: "A process which directly activates any of the steps required for programmed cell death." [GOC:lr]
synonym: "induction of non-apoptotic programmed cell death" NARROW []
synonym: "induction of nonapoptotic programmed cell death" NARROW []
is_a: GO:0043068 ! positive regulation of programmed cell death

[Term]
id: GO:0012505
name: endomembrane system
namespace: cellular_component
def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh]
subset: goslim_candida
subset: goslim_yeast
xref: Wikipedia:Endomembrane_system
is_a: GO:0044464 ! cell part

[Term]
id: GO:0012506
name: vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah]
xref: NIF_Subcellular:sao1153182838
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0012505 ! endomembrane system
relationship: part_of GO:0031988 ! membrane-bounded vesicle

[Term]
id: GO:0012507
name: ER to Golgi transport vesicle membrane
namespace: cellular_component
alt_id: GO:0030664
def: "The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "COPII coated vesicle membrane" EXACT []
synonym: "endoplasmic reticulum to Golgi transport vesicle membrane" EXACT []
synonym: "endoplasmic reticulum-Golgi transport vesicle membrane" EXACT []
synonym: "ER-Golgi transport vesicle membrane" EXACT []
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030662 ! coated vesicle membrane
relationship: part_of GO:0030134 ! ER to Golgi transport vesicle

[Term]
id: GO:0012508
name: Golgi to ER transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER." [GOC:ai]
synonym: "Golgi to endoplasmic reticulum transport vesicle membrane" EXACT []
synonym: "Golgi-endoplasmic reticulum transport vesicle membrane" EXACT []
synonym: "Golgi-ER transport vesicle membrane" EXACT []
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030663 ! COPI coated vesicle membrane
relationship: part_of GO:0030142 ! Golgi to ER transport vesicle

[Term]
id: GO:0012509
name: inter-Golgi transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle transporting substances within the Golgi." [GOC:ai]
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030663 ! COPI coated vesicle membrane
relationship: part_of GO:0030143 ! inter-Golgi transport vesicle

[Term]
id: GO:0012510
name: trans-Golgi network transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell." [GOC:ai]
synonym: "TGN transport vesicle membrane" EXACT []
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030660 ! Golgi-associated vesicle membrane
is_a: GO:0030665 ! clathrin coated vesicle membrane
relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle

[Term]
id: GO:0012511
name: monolayer-surrounded lipid storage body
namespace: cellular_component
alt_id: GO:0009520
def: "A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins." [GOC:mtg_sensu, ISBN:0943088372]
synonym: "oil body" EXACT []
synonym: "oilbody" EXACT []
synonym: "oleosome" EXACT []
synonym: "spherosome" EXACT []
xref: Wikipedia:Oil_body
is_a: GO:0005811 ! lipid particle
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0014001
name: sclerenchyma cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a sclerenchyma cell. A sclerenchyma cell is a plant cell with thick lignified walls, normally dead at maturity and specialized for structural strength. Includes fiber cells, that are greatly elongated; and sclereids, that are more isodiametric. Intermediate types exist. Cells may or may not be devoid of protoplasm at maturity. Cell form and size are variable." [CL:0000276, GOC:ef, GOC:jic, http://cancerweb.ncl.ac.uk, PO:0000077]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0014002
name: astrocyte development
namespace: biological_process
def: "The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:dgh, GOC:ef]
synonym: "astrocyte cell development" EXACT []
is_a: GO:0021782 ! glial cell development
relationship: part_of GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0014003
name: oligodendrocyte development
namespace: biological_process
def: "The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system." [GOC:dgh, GOC:ef]
synonym: "oligodendrocyte cell development" EXACT []
is_a: GO:0021782 ! glial cell development
relationship: part_of GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0014004
name: microglia differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system." [GOC:ef]
synonym: "microglial cell differentiation" EXACT []
is_a: GO:0010001 ! glial cell differentiation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0014005
name: microglia development
namespace: biological_process
def: "The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh, GOC:ef]
synonym: "microglial cell development" EXACT []
is_a: GO:0021782 ! glial cell development
relationship: part_of GO:0014004 ! microglia differentiation

[Term]
id: GO:0014006
name: regulation of microglia differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microglia differentiation, the process whereby a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef]
synonym: "regulation of microglial cell differentiation" EXACT []
is_a: GO:0045685 ! regulation of glial cell differentiation
relationship: regulates GO:0014004 ! microglia differentiation

[Term]
id: GO:0014007
name: negative regulation of microglia differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglia differentiation, the process whereby a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef]
synonym: "down regulation of microglia differentiation" EXACT []
synonym: "down-regulation of microglia differentiation" EXACT []
synonym: "downregulation of microglia differentiation" EXACT []
synonym: "inhibition of microglia differentiation" NARROW []
synonym: "negative regulation of microglial cell differentiation" EXACT []
is_a: GO:0014006 ! regulation of microglia differentiation
is_a: GO:0045686 ! negative regulation of glial cell differentiation
relationship: negatively_regulates GO:0014004 ! microglia differentiation

[Term]
id: GO:0014008
name: positive regulation of microglia differentiation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process whereby a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef]
synonym: "activation of microglia differentiation" NARROW []
synonym: "positive regulation of microglial cell differentiation" EXACT []
synonym: "stimulation of microglia differentiation" NARROW []
synonym: "up regulation of microglia differentiation" EXACT []
synonym: "up-regulation of microglia differentiation" EXACT []
synonym: "upregulation of microglia differentiation" EXACT []
is_a: GO:0014006 ! regulation of microglia differentiation
is_a: GO:0045687 ! positive regulation of glial cell differentiation
relationship: positively_regulates GO:0014004 ! microglia differentiation

[Term]
id: GO:0014009
name: glial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others." [GOC:ef, ISBN:0878932585]
synonym: "glia proliferation" EXACT []
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0042063 ! gliogenesis

[Term]
id: GO:0014010
name: Schwann cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:ef, ISBN:0878932585]
is_a: GO:0014009 ! glial cell proliferation

[Term]
id: GO:0014011
name: Schwann cell proliferation involved in axon regeneration
namespace: biological_process
def: "The multiplication or reproduction of Schwann cells by cell division, resulting in the expansion of their population in response to an axonal lesion. The newly generated Schwann cells support subsequent axon regeneration in the peripheral nervous system." [GOC:ef, ISBN:0878932585]
is_a: GO:0014010 ! Schwann cell proliferation
relationship: part_of GO:0014012 ! axon regeneration in the peripheral nervous system

[Term]
id: GO:0014012
name: axon regeneration in the peripheral nervous system
namespace: biological_process
def: "The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury." [GOC:ef]
is_a: GO:0031103 ! axon regeneration

[Term]
id: GO:0014013
name: regulation of gliogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef]
is_a: GO:0050767 ! regulation of neurogenesis
relationship: regulates GO:0042063 ! gliogenesis

[Term]
id: GO:0014014
name: negative regulation of gliogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef]
synonym: "down regulation of gliogenesis" EXACT []
synonym: "down-regulation of gliogenesis" EXACT []
synonym: "downregulation of gliogenesis" EXACT []
synonym: "inhibition of gliogenesis" NARROW []
is_a: GO:0014013 ! regulation of gliogenesis
is_a: GO:0050768 ! negative regulation of neurogenesis
relationship: negatively_regulates GO:0042063 ! gliogenesis

[Term]
id: GO:0014015
name: positive regulation of gliogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef]
synonym: "activation of gliogenesis" NARROW []
synonym: "stimulation of gliogenesis" NARROW []
synonym: "up regulation of gliogenesis" EXACT []
synonym: "up-regulation of gliogenesis" EXACT []
synonym: "upregulation of gliogenesis" EXACT []
is_a: GO:0014013 ! regulation of gliogenesis
is_a: GO:0050769 ! positive regulation of neurogenesis
relationship: positively_regulates GO:0042063 ! gliogenesis

[Term]
id: GO:0014016
name: neuroblast differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts." [GOC:ef, ISBN:0878932585]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0014017
name: neuroblast fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast." [GOC:ef, ISBN:0878932585]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0014016 ! neuroblast differentiation

[Term]
id: GO:0014018
name: neuroblast fate specification
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into a neuroblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, ISBN:0878932585]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0014017 ! neuroblast fate commitment

[Term]
id: GO:0014019
name: neuroblast development
namespace: biological_process
def: "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0014016 ! neuroblast differentiation

[Term]
id: GO:0014020
name: primary neural tube formation
namespace: biological_process
def: "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." [GOC:ef, ISBN:0878932585]
synonym: "primary neural tube morphogenesis" EXACT [GOC:dph]
synonym: "primary neurulation" EXACT []
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0001841 ! neural tube formation

[Term]
id: GO:0014021
name: secondary neural tube formation
namespace: biological_process
alt_id: GO:0014026
def: "The formation of the neural tube by coalescence of mesenchymal cells followed by their conversion to epithelial cells to form a solid cord that subsequently hollows out (cavitates) to create a hollow tube. Secondary neurulation is the typical mechanism of formation of the neural tube posterior to the posterior neuropore in mammals." [GOC:ef, ISBN:0878932585]
synonym: "medullary cord biosynthesis" EXACT []
synonym: "medullary cord formation" EXACT []
synonym: "neural rod formation" RELATED []
synonym: "secondary neurulation" EXACT []
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0001841 ! neural tube formation

[Term]
id: GO:0014022
name: neural plate elongation
namespace: biological_process
def: "The process by which the neural plate is shaped by the intrinsic movement of the epidermal and neural plate regions." [GOC:ef, ISBN:0878932585]
is_a: GO:0002011 ! morphogenesis of an epithelial sheet
relationship: part_of GO:0001839 ! neural plate morphogenesis

[Term]
id: GO:0014023
name: neural rod formation
namespace: biological_process
def: "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0014020 ! primary neural tube formation

[Term]
id: GO:0014024
name: neural rod cavitation
namespace: biological_process
def: "The process of rod cavitation, which is the formation of a lumen in the neural rod during primary neurulation, producing the neural tube." [GOC:ef, PMID:15327780]
is_a: GO:0060605 ! tube lumen cavitation
relationship: part_of GO:0014020 ! primary neural tube formation

[Term]
id: GO:0014025
name: neural keel formation
namespace: biological_process
def: "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0014023 ! neural rod formation

[Term]
id: GO:0014027
name: secondary neural tube rod cavitation
namespace: biological_process
def: "The process of medullary cavitation, which is the formation of a lumen in the medullary cord during secondary neurulation, producing the neural tube." [GOC:ef, PMID:15327780]
synonym: "medullary rod cavitation" EXACT []
is_a: GO:0060605 ! tube lumen cavitation
relationship: part_of GO:0014021 ! secondary neural tube formation

[Term]
id: GO:0014028
name: notochord formation
namespace: biological_process
def: "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column." [GOC:dh, GOC:ef]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007399 ! nervous system development
relationship: part_of GO:0048570 ! notochord morphogenesis

[Term]
id: GO:0014029
name: neural crest formation
namespace: biological_process
def: "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:dh, GOC:ef]
is_a: GO:0001837 ! epithelial to mesenchymal transition
relationship: part_of GO:0021915 ! neural tube development

[Term]
id: GO:0014030
name: mesenchymal cell fate commitment
namespace: biological_process
def: "The process by which a cell becomes committed to become a mesenchymal cell." [GOC:dh, GOC:ef]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0048762 ! mesenchymal cell differentiation

[Term]
id: GO:0014031
name: mesenchymal cell development
namespace: biological_process
def: "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0048762 ! mesenchymal cell differentiation

[Term]
id: GO:0014032
name: neural crest cell development
namespace: biological_process
def: "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef]
is_a: GO:0014031 ! mesenchymal cell development
relationship: part_of GO:0014033 ! neural crest cell differentiation

[Term]
id: GO:0014033
name: neural crest cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a neural crest cell." [GOC:dh, GOC:ef]
is_a: GO:0048762 ! mesenchymal cell differentiation

[Term]
id: GO:0014034
name: neural crest cell fate commitment
namespace: biological_process
def: "The process by which a cell becomes committed to become a neural crest cell." [GOC:dh, GOC:ef]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0014029 ! neural crest formation
relationship: part_of GO:0014033 ! neural crest cell differentiation

[Term]
id: GO:0014035
name: neural crest cell fate determination
namespace: biological_process
def: "The process by which a cell becomes capable of differentiating autonomously into a neural crest cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dh, GOC:ef]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0014034 ! neural crest cell fate commitment

[Term]
id: GO:0014036
name: neural crest cell fate specification
namespace: biological_process
def: "The process by which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dh, GOC:ef]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0014034 ! neural crest cell fate commitment

[Term]
id: GO:0014037
name: Schwann cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:ef]
is_a: GO:0010001 ! glial cell differentiation
relationship: part_of GO:0007422 ! peripheral nervous system development

[Term]
id: GO:0014038
name: regulation of Schwann cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Schwann cell differentiation." [GOC:ef]
is_a: GO:0045685 ! regulation of glial cell differentiation
relationship: regulates GO:0014037 ! Schwann cell differentiation

[Term]
id: GO:0014039
name: negative regulation of Schwann cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell differentiation." [GOC:ef]
synonym: "down regulation of Schwann cell differentiation" EXACT []
synonym: "down-regulation of Schwann cell differentiation" EXACT []
synonym: "downregulation of Schwann cell differentiation" EXACT []
synonym: "inhibition of Schwann cell differentiation" NARROW []
is_a: GO:0014038 ! regulation of Schwann cell differentiation
is_a: GO:0045686 ! negative regulation of glial cell differentiation
relationship: negatively_regulates GO:0014037 ! Schwann cell differentiation

[Term]
id: GO:0014040
name: positive regulation of Schwann cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation." [GOC:ef]
synonym: "activation of Schwann cell differentiation" NARROW []
synonym: "stimulation of Schwann cell differentiation" NARROW []
synonym: "up regulation of Schwann cell differentiation" EXACT []
synonym: "up-regulation of Schwann cell differentiation" EXACT []
synonym: "upregulation of Schwann cell differentiation" EXACT []
is_a: GO:0014038 ! regulation of Schwann cell differentiation
is_a: GO:0045687 ! positive regulation of glial cell differentiation
relationship: positively_regulates GO:0014037 ! Schwann cell differentiation

[Term]
id: GO:0014041
name: regulation of neuron maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change." [GOC:ef]
is_a: GO:0045664 ! regulation of neuron differentiation
relationship: regulates GO:0042551 ! neuron maturation

[Term]
id: GO:0014042
name: positive regulation of neuron maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron maturation." [GOC:ef]
synonym: "activation of neuron maturation" NARROW []
synonym: "stimulation of neuron maturation" NARROW []
synonym: "up regulation of neuron maturation" EXACT []
synonym: "up-regulation of neuron maturation" EXACT []
synonym: "upregulation of neuron maturation" EXACT []
is_a: GO:0014041 ! regulation of neuron maturation
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0042551 ! neuron maturation

[Term]
id: GO:0014043
name: negative regulation of neuron maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron maturation." [GOC:ef]
synonym: "down regulation of neuron maturation" EXACT []
synonym: "down-regulation of neuron maturation" EXACT []
synonym: "downregulation of neuron maturation" EXACT []
synonym: "inhibition of neuron maturation" NARROW []
is_a: GO:0014041 ! regulation of neuron maturation
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0042551 ! neuron maturation

[Term]
id: GO:0014044
name: Schwann cell development
namespace: biological_process
def: "The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:dgh, GOC:ef]
is_a: GO:0021782 ! glial cell development
relationship: part_of GO:0014037 ! Schwann cell differentiation

[Term]
id: GO:0014045
name: establishment of endothelial blood-brain barrier
namespace: biological_process
def: "Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dgh, GOC:dph, GOC:sart]
synonym: "establishment of endothelial blood/brain barrier" EXACT []
is_a: GO:0060856 ! establishment of blood-brain barrier
is_a: GO:0061028 ! establishment of endothelial barrier
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0014046
name: dopamine secretion
namespace: biological_process
def: "The regulated release of dopamine by a cell or group of cells. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone." [GOC:ef]
is_a: GO:0015872 ! dopamine transport
is_a: GO:0023061 ! signal release
is_a: GO:0050432 ! catecholamine secretion

[Term]
id: GO:0014047
name: glutamate secretion
namespace: biological_process
def: "The controlled release of glutamate by a cell or group of cells. The glutamate is the most abundant excitatory neurotransmitter in the nervous system." [GOC:ef]
xref: Reactome:210500 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:449174 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:470287 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:487963 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:507937 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:517809 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:526641 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:531439 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:536813 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:542571 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:547892 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:552470 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:558078 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:568726 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:581929 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:585964 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:592821 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:598200 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:599766 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:600674 "Glutamate Neurotransmitter Release Cycle"
xref: Reactome:602581 "Glutamate Neurotransmitter Release Cycle"
is_a: GO:0003001 ! generation of a signal involved in cell-cell signaling
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0014048
name: regulation of glutamate secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of glutamate." [GOC:ef]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0014047 ! glutamate secretion

[Term]
id: GO:0014049
name: positive regulation of glutamate secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate." [GOC:ef]
synonym: "activation of glutamate secretion" NARROW []
synonym: "stimulation of glutamate secretion" NARROW []
synonym: "up regulation of glutamate secretion" EXACT []
synonym: "up-regulation of glutamate secretion" EXACT []
synonym: "upregulation of glutamate secretion" EXACT []
is_a: GO:0014048 ! regulation of glutamate secretion
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051047 ! positive regulation of secretion
relationship: positively_regulates GO:0014047 ! glutamate secretion

[Term]
id: GO:0014050
name: negative regulation of glutamate secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of glutamate." [GOC:ef]
synonym: "down regulation of glutamate secretion" EXACT []
synonym: "down-regulation of glutamate secretion" EXACT []
synonym: "downregulation of glutamate secretion" EXACT []
synonym: "inhibition of glutamate secretion" NARROW []
is_a: GO:0014048 ! regulation of glutamate secretion
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051048 ! negative regulation of secretion
relationship: negatively_regulates GO:0014047 ! glutamate secretion

[Term]
id: GO:0014051
name: gamma-aminobutyric acid secretion
namespace: biological_process
def: "The regulated release of gamm-aminobutyric acid by a cell or group of cells. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues." [GOC:ef]
synonym: "GABA secretion" EXACT []
is_a: GO:0003001 ! generation of a signal involved in cell-cell signaling
is_a: GO:0015812 ! gamma-aminobutyric acid transport
is_a: GO:0046903 ! secretion

[Term]
id: GO:0014052
name: regulation of gamma-aminobutyric acid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef]
synonym: "regulation of GABA secretion" EXACT []
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051955 ! regulation of amino acid transport
relationship: regulates GO:0014051 ! gamma-aminobutyric acid secretion

[Term]
id: GO:0014053
name: negative regulation of gamma-aminobutyric acid secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef]
synonym: "down regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "down-regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "downregulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "inhibition of gamma-aminobutyric acid secretion" NARROW []
synonym: "negative regulation of GABA secretion" EXACT []
is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051956 ! negative regulation of amino acid transport
relationship: negatively_regulates GO:0014051 ! gamma-aminobutyric acid secretion

[Term]
id: GO:0014054
name: positive regulation of gamma-aminobutyric acid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef]
synonym: "activation of gamma-aminobutyric acid secretion" NARROW []
synonym: "positive regulation of GABA secretion" EXACT []
synonym: "stimulation of gamma-aminobutyric acid secretion" NARROW []
synonym: "up regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "up-regulation of gamma-aminobutyric acid secretion" EXACT []
synonym: "upregulation of gamma-aminobutyric acid secretion" EXACT []
is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051957 ! positive regulation of amino acid transport
relationship: positively_regulates GO:0014051 ! gamma-aminobutyric acid secretion

[Term]
id: GO:0014055
name: acetylcholine secretion
namespace: biological_process
def: "The regulated release of acetylcholine by a cell or group of cells. The acetylcholine is a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS)." [GOC:ef]
is_a: GO:0007269 ! neurotransmitter secretion
is_a: GO:0015870 ! acetylcholine transport

[Term]
id: GO:0014056
name: regulation of acetylcholine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef]
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0051952 ! regulation of amine transport
relationship: regulates GO:0014055 ! acetylcholine secretion

[Term]
id: GO:0014057
name: positive regulation of acetylcholine secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef]
synonym: "activation of acetylcholine secretion" NARROW []
synonym: "stimulation of acetylcholine secretion" NARROW []
synonym: "up regulation of acetylcholine secretion" EXACT []
synonym: "up-regulation of acetylcholine secretion" EXACT []
synonym: "upregulation of acetylcholine secretion" EXACT []
is_a: GO:0001956 ! positive regulation of neurotransmitter secretion
is_a: GO:0014056 ! regulation of acetylcholine secretion
is_a: GO:0051954 ! positive regulation of amine transport
relationship: positively_regulates GO:0014055 ! acetylcholine secretion

[Term]
id: GO:0014058
name: negative regulation of acetylcholine secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef]
synonym: "down regulation of acetylcholine secretion" EXACT []
synonym: "down-regulation of acetylcholine secretion" EXACT []
synonym: "downregulation of acetylcholine secretion" EXACT []
synonym: "inhibition of acetylcholine secretion" NARROW []
is_a: GO:0014056 ! regulation of acetylcholine secretion
is_a: GO:0046929 ! negative regulation of neurotransmitter secretion
is_a: GO:0051953 ! negative regulation of amine transport
relationship: negatively_regulates GO:0014055 ! acetylcholine secretion

[Term]
id: GO:0014059
name: regulation of dopamine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef]
is_a: GO:0050433 ! regulation of catecholamine secretion
relationship: regulates GO:0014046 ! dopamine secretion

[Term]
id: GO:0014060
name: regulation of epinephrine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of epinephrine." [GOC:ef]
synonym: "regulation of adrenaline secretion" EXACT []
is_a: GO:0050433 ! regulation of catecholamine secretion
relationship: regulates GO:0048242 ! epinephrine secretion

[Term]
id: GO:0014061
name: regulation of norepinephrine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine." [GOC:ef]
synonym: "regulation of noradrenaline secretion" EXACT []
is_a: GO:0050433 ! regulation of catecholamine secretion
relationship: regulates GO:0048243 ! norepinephrine secretion

[Term]
id: GO:0014062
name: regulation of serotonin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of serotonin." [GOC:ef]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051952 ! regulation of amine transport
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0001820 ! serotonin secretion

[Term]
id: GO:0014063
name: negative regulation of serotonin secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of serotonin." [GOC:ef]
synonym: "down regulation of serotonin secretion" EXACT []
synonym: "down-regulation of serotonin secretion" EXACT []
synonym: "downregulation of serotonin secretion" EXACT []
synonym: "inhibition of serotonin secretion" NARROW []
is_a: GO:0014062 ! regulation of serotonin secretion
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051953 ! negative regulation of amine transport
relationship: negatively_regulates GO:0001820 ! serotonin secretion

[Term]
id: GO:0014064
name: positive regulation of serotonin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin." [GOC:ef]
synonym: "activation of serotonin secretion" NARROW []
synonym: "stimulation of serotonin secretion" NARROW []
synonym: "up regulation of serotonin secretion" EXACT []
synonym: "up-regulation of serotonin secretion" EXACT []
synonym: "upregulation of serotonin secretion" EXACT []
is_a: GO:0014062 ! regulation of serotonin secretion
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051954 ! positive regulation of amine transport
relationship: positively_regulates GO:0001820 ! serotonin secretion

[Term]
id: GO:0014065
name: phosphoinositide 3-kinase cascade
namespace: biological_process
def: "A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions." [GOC:ef, http://www.biocarta.com, Wikipedia:PI3K]
synonym: "PI 3-kinase cascade" EXACT []
synonym: "PI3K cascade" EXACT []
is_a: GO:0007243 ! protein kinase cascade

[Term]
id: GO:0014066
name: regulation of phosphoinositide 3-kinase cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphoinositide 3-kinase cascade." [GOC:ef]
synonym: "regulation of PI 3-kinase cascade" RELATED []
synonym: "regulation of PI3K cascade" EXACT []
is_a: GO:0010627 ! regulation of protein kinase cascade
relationship: regulates GO:0014065 ! phosphoinositide 3-kinase cascade

[Term]
id: GO:0014067
name: negative regulation of phosphoinositide 3-kinase cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the phosphoinositide 3-kinase cascade." [GOC:ef]
synonym: "down regulation of phosphoinositide 3-kinase cascade" EXACT []
synonym: "down-regulation of phosphoinositide 3-kinase cascade" EXACT []
synonym: "downregulation of phosphoinositide 3-kinase cascade" EXACT []
synonym: "inhibition of phosphoinositide 3-kinase cascade" NARROW []
synonym: "negative regulation of PI 3-kinase cascade" EXACT []
synonym: "negative regulation of PI3K cascade" EXACT []
is_a: GO:0010741 ! negative regulation of protein kinase cascade
is_a: GO:0014066 ! regulation of phosphoinositide 3-kinase cascade
relationship: negatively_regulates GO:0014065 ! phosphoinositide 3-kinase cascade

[Term]
id: GO:0014068
name: positive regulation of phosphoinositide 3-kinase cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphoinositide 3-kinase cascade." [GOC:ef]
synonym: "activation of phosphoinositide 3-kinase cascade" NARROW []
synonym: "positive regulation of PI 3-kinase cascade" EXACT []
synonym: "positive regulation of PI3K cascade" EXACT []
synonym: "stimulation of phosphoinositide 3-kinase cascade" NARROW []
synonym: "up regulation of phosphoinositide 3-kinase cascade" EXACT []
synonym: "up-regulation of phosphoinositide 3-kinase cascade" EXACT []
synonym: "upregulation of phosphoinositide 3-kinase cascade" EXACT []
is_a: GO:0010740 ! positive regulation of protein kinase cascade
is_a: GO:0014066 ! regulation of phosphoinositide 3-kinase cascade
relationship: positively_regulates GO:0014065 ! phosphoinositide 3-kinase cascade

[Term]
id: GO:0014069
name: postsynaptic density
namespace: cellular_component
def: "The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases." [GOC:ef, GOC:jic, http://molneuro.kaist.ac.kr/psd, http://wikipedia.org/Postsynaptic_density, PMID:14532281]
synonym: "post synaptic density" EXACT []
synonym: "post-synaptic density" EXACT []
xref: NIF_Subcellular:sao1196688972
xref: Wikipedia:Postsynaptic_density
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044456 ! synapse part

[Term]
id: GO:0014070
name: response to organic cyclic substance
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic substance stimulus." [ChEBI:33832, GOC:ef]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0014071
name: response to cycloalkane
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n." [ChEBI:23453, GOC:ef]
is_a: GO:0014070 ! response to organic cyclic substance

[Term]
id: GO:0014072
name: response to isoquinoline alkaloid
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids." [ChEBI:24921, GOC:ef, http://cancerweb.ncl.ac.uk]
is_a: GO:0014070 ! response to organic cyclic substance
is_a: GO:0043279 ! response to alkaloid

[Term]
id: GO:0014073
name: response to tropane
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine." [ChEBI:35615, GOC:ef]
is_a: GO:0014070 ! response to organic cyclic substance

[Term]
id: GO:0014074
name: response to purine
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine stimulus. Aside from DNA and RNA, purines are biochemically significant components in a number of other important biomolecules, such as ATP, GTP, cyclic AMP, NADH, and coenzyme A." [ChEBI:26401, GOC:ef]
is_a: GO:0014070 ! response to organic cyclic substance

[Term]
id: GO:0014075
name: response to amine stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [ChEBI:32952, GOC:ef]
is_a: GO:0010243 ! response to organic nitrogen

[Term]
id: GO:0014076
name: response to fluoxetine
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor." [ChEBI:5118, GOC:ef]
synonym: "selective serotonin reuptake inhibitor" RELATED []
is_a: GO:0014070 ! response to organic cyclic substance

[Term]
id: GO:0014701
name: junctional sarcoplasmic reticulum membrane
namespace: cellular_component
def: "The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane." [GOC:mtg_muscle]
is_a: GO:0033017 ! sarcoplasmic reticulum membrane

[Term]
id: GO:0014702
name: free sarcoplasmic reticulum membrane
namespace: cellular_component
def: "The part of the sarcoplasmic reticulum membrane that contains calcium pumps and is devoted to calcium uptake. The free sarcoplasmic reticulum membrane consists of the longitudinal sarcoplasmic reticulum membrane and the non-junctional region of the terminal cisterna membrane." [GOC:mtg_muscle]
is_a: GO:0033017 ! sarcoplasmic reticulum membrane

[Term]
id: GO:0014703
name: oscillatory muscle contraction
namespace: biological_process
def: "A process whereby force is generated within oscillatory skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Oscillatory muscle contraction occurs in insect wing muscles and is characterized by asynchrony between action potential and contraction and by stretch activation." [GOC:mtg_muscle]
is_a: GO:0003010 ! voluntary skeletal muscle contraction

[Term]
id: GO:0014704
name: intercalated disc
namespace: cellular_component
def: "A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." [GOC:mtg_muscle, PMID:11732910]
synonym: "intercalated disk" EXACT []
xref: Wikipedia:Intercalated_disc
is_a: GO:0044291 ! cell-cell contact zone

[Term]
id: GO:0014705
name: C zone
namespace: cellular_component
def: "A region of the A band in which myosin-binding protein C is located and that can be seen by electron microscopy. This is a functional zone that also includes myosin." [GOC:mtg_muscle]
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0031672 ! A band

[Term]
id: GO:0014706
name: striated muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle]
is_a: GO:0060537 ! muscle tissue development

[Term]
id: GO:0014707
name: branchiomeric skeletal muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. The branchiomeric muscle is derived from cranial mesoderm and controls facial expression, pharyngeal and laryngeal function, operating the jaw. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. Branchiomeric muscles of mammals correspond to the gill musculature of fish." [GOC:mtg_muscle]
is_a: GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0014708
name: regulation of somitomeric trunk muscle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of somitomeric trunk muscle development." [GOC:mtg_muscle]
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
relationship: regulates GO:0002075 ! somitomeric trunk muscle development

[Term]
id: GO:0014709
name: positive regulation of somitomeric trunk muscle development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle]
is_a: GO:0014708 ! regulation of somitomeric trunk muscle development
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
relationship: positively_regulates GO:0002075 ! somitomeric trunk muscle development

[Term]
id: GO:0014710
name: negative regulation of somitomeric trunk muscle development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle]
is_a: GO:0014708 ! regulation of somitomeric trunk muscle development
is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development
relationship: negatively_regulates GO:0002075 ! somitomeric trunk muscle development

[Term]
id: GO:0014711
name: regulation of branchiomeric skeletal muscle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle]
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
relationship: regulates GO:0014707 ! branchiomeric skeletal muscle development

[Term]
id: GO:0014712
name: positive regulation of branchiomeric skeletal muscle development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle]
is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
relationship: positively_regulates GO:0014707 ! branchiomeric skeletal muscle development

[Term]
id: GO:0014713
name: negative regulation of branchiomeric skeletal muscle development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle]
is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development
is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development
relationship: negatively_regulates GO:0014707 ! branchiomeric skeletal muscle development

[Term]
id: GO:0014714
name: myoblast cell fate commitment in head
namespace: biological_process
def: "The process, taking place in the head, whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast cell. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
is_a: GO:0048625 ! myoblast cell fate commitment

[Term]
id: GO:0014715
name: myoblast cell fate commitment in trunk
namespace: biological_process
def: "The process taking place in the trunk whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast cell. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
is_a: GO:0048625 ! myoblast cell fate commitment

[Term]
id: GO:0014716
name: satellite cell asymmetric division involved in skeletal muscle regeneration
namespace: biological_process
def: "Satellite cell asymmetric division that occurs during a process in which damaged muscle tissue is being rebuilt. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle]
is_a: GO:0014833 ! satellite cell asymmetric division
relationship: part_of GO:0014834 ! satellite cell maintenance involved in skeletal muscle regeneration

[Term]
id: GO:0014717
name: regulation of satellite cell activation involved in skeletal muscle regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of satellite cell activation. The satellite cell activation is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle]
is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration
is_a: GO:0050865 ! regulation of cell activation
relationship: regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration

[Term]
id: GO:0014718
name: positive regulation of satellite cell activation involved in skeletal muscle regeneration
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle]
is_a: GO:0014717 ! regulation of satellite cell activation involved in skeletal muscle regeneration
is_a: GO:0050867 ! positive regulation of cell activation
relationship: part_of GO:0043415 ! positive regulation of skeletal muscle tissue regeneration
relationship: positively_regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration

[Term]
id: GO:0014719
name: satellite cell activation
namespace: biological_process
def: "A change in the morphology or behavior of a satellite cell resulting from exposure to an activating factor such as a cellular or soluble ligand. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle]
is_a: GO:0001775 ! cell activation

[Term]
id: GO:0014720
name: tonic skeletal muscle contraction
namespace: biological_process
def: "A process whereby force is generated within tonic skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The tonic skeletal muscle is characterized by long lasting contractile responses and high resistance to fatigue." [GOC:mtg_muscle]
is_a: GO:0003010 ! voluntary skeletal muscle contraction

[Term]
id: GO:0014721
name: twitch skeletal muscle contraction
namespace: biological_process
def: "A process whereby force is generated within twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The twitch skeletal muscle responds to neurostimulations with a contraction followed by a relaxation." [GOC:mtg_muscle]
is_a: GO:0003010 ! voluntary skeletal muscle contraction

[Term]
id: GO:0014722
name: regulation of skeletal muscle contraction by calcium ion signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:mtg_muscle]
synonym: "regulation of skeletal muscle contraction by calcium ion signalling" EXACT []
is_a: GO:0014819 ! regulation of skeletal muscle contraction

[Term]
id: GO:0014723
name: regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing calcium ion binding affinity of the myofibril." [GOC:mtg_muscle]
synonym: "regulation of calcium ion sensitivity of myofibril involved in skeletal muscle contraction" EXACT []
is_a: GO:0014722 ! regulation of skeletal muscle contraction by calcium ion signaling

[Term]
id: GO:0014724
name: regulation of twitch skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of twitch skeletal muscle contraction." [GOC:mtg_muscle]
is_a: GO:0014819 ! regulation of skeletal muscle contraction
relationship: regulates GO:0014721 ! twitch skeletal muscle contraction

[Term]
id: GO:0014725
name: regulation of extraocular skeletal muscle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle]
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
relationship: regulates GO:0002074 ! extraocular skeletal muscle development

[Term]
id: GO:0014726
name: negative regulation of extraocular skeletal muscle development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle]
is_a: GO:0014725 ! regulation of extraocular skeletal muscle development
is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development
relationship: negatively_regulates GO:0002074 ! extraocular skeletal muscle development

[Term]
id: GO:0014727
name: positive regulation of extraocular skeletal muscle development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle]
is_a: GO:0014725 ! regulation of extraocular skeletal muscle development
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
relationship: positively_regulates GO:0002074 ! extraocular skeletal muscle development

[Term]
id: GO:0014728
name: regulation of the force of skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the force of skeletal muscle contraction. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through the formation of cross bridges." [GOC:mtg_muscle]
is_a: GO:0014862 ! regulation of skeletal muscle contraction by chemo-mechanical energy conversion

[Term]
id: GO:0014729
name: regulation of the velocity of shortening of skeletal muscle during contraction
namespace: biological_process
def: "Any process that modulates velocity of shortening of a skeletal muscle contraction. The shortening leads to reduction of the length of muscle fibers and sarcomeres." [GOC:mtg_muscle]
is_a: GO:0014862 ! regulation of skeletal muscle contraction by chemo-mechanical energy conversion
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0014730
name: skeletal muscle regeneration at neuromuscular junction
namespace: biological_process
def: "The regrowth of muscle tissue to repair injured or damaged muscle fibers in the postnatal stage at the neuromuscular junction. Regeneration of neuromuscular junctions occurs in an orderly way and relies on communication between nerve and muscle. Skeletal myofibers regenerate after injury and form neuro-muscular junctions with motor axons similar to normal ones. Regenerating myofibers develop within the basal lamina sheaths (satellite cells) of original myofibers." [GOC:mtg_muscle]
is_a: GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014731
name: spectrin-associated cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane." [GOC:mtg_muscle, PMID:15970557]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0014732
name: skeletal muscle atrophy
namespace: biological_process
def: "A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle]
is_a: GO:0014891 ! striated muscle atrophy
is_a: GO:0043501 ! skeletal muscle adaptation

[Term]
id: GO:0014733
name: regulation of skeletal muscle adaptation
namespace: biological_process
def: "Any process by which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle]
synonym: "regulation of skeletal muscle plasticity" RELATED []
is_a: GO:0043502 ! regulation of muscle adaptation
relationship: regulates GO:0043501 ! skeletal muscle adaptation

[Term]
id: GO:0014734
name: skeletal muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle]
is_a: GO:0014897 ! striated muscle hypertrophy
is_a: GO:0043501 ! skeletal muscle adaptation

[Term]
id: GO:0014735
name: regulation of muscle atrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle atrophy." [GOC:mtg_muscle]
is_a: GO:0043502 ! regulation of muscle adaptation
relationship: regulates GO:0014889 ! muscle atrophy

[Term]
id: GO:0014736
name: negative regulation of muscle atrophy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle atrophy." [GOC:mtg_muscle]
is_a: GO:0014735 ! regulation of muscle atrophy
is_a: GO:0014745 ! negative regulation of muscle adaptation
relationship: negatively_regulates GO:0014889 ! muscle atrophy

[Term]
id: GO:0014737
name: positive regulation of muscle atrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle atrophy." [GOC:mtg_muscle]
is_a: GO:0014735 ! regulation of muscle atrophy
is_a: GO:0014744 ! positive regulation of muscle adaptation
relationship: positively_regulates GO:0014889 ! muscle atrophy

[Term]
id: GO:0014738
name: regulation of muscle hyperplasia
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle hyperplasia." [GOC:mtg_muscle]
is_a: GO:0043502 ! regulation of muscle adaptation
relationship: regulates GO:0014900 ! muscle hyperplasia

[Term]
id: GO:0014739
name: positive regulation of muscle hyperplasia
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle hyperplasia." [GOC:mtg_muscle]
is_a: GO:0014738 ! regulation of muscle hyperplasia
is_a: GO:0014744 ! positive regulation of muscle adaptation
relationship: positively_regulates GO:0014900 ! muscle hyperplasia

[Term]
id: GO:0014740
name: negative regulation of muscle hyperplasia
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hyperplasia." [GOC:mtg_muscle]
is_a: GO:0014738 ! regulation of muscle hyperplasia
is_a: GO:0014745 ! negative regulation of muscle adaptation
relationship: negatively_regulates GO:0014900 ! muscle hyperplasia

[Term]
id: GO:0014741
name: negative regulation of muscle hypertrophy
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy." [GOC:mtg_muscle]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014742
name: positive regulation of muscle hypertrophy
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle]
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014743
name: regulation of muscle hypertrophy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle]
is_a: GO:0090257 ! regulation of muscle system process
relationship: regulates GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014744
name: positive regulation of muscle adaptation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle adaptation." [GOC:mtg_muscle]
synonym: "positive regulation of muscle plasticity" RELATED []
is_a: GO:0043502 ! regulation of muscle adaptation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0043500 ! muscle adaptation

[Term]
id: GO:0014745
name: negative regulation of muscle adaptation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation." [GOC:mtg_muscle]
synonym: "negative regulation of muscle plasticity" RELATED []
is_a: GO:0043502 ! regulation of muscle adaptation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0043500 ! muscle adaptation

[Term]
id: GO:0014746
name: regulation of tonic skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:mtg_muscle]
is_a: GO:0014819 ! regulation of skeletal muscle contraction
relationship: regulates GO:0014720 ! tonic skeletal muscle contraction

[Term]
id: GO:0014747
name: positive regulation of tonic skeletal muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014746 ! regulation of tonic skeletal muscle contraction
is_a: GO:0045989 ! positive regulation of striated muscle contraction
relationship: positively_regulates GO:0014720 ! tonic skeletal muscle contraction

[Term]
id: GO:0014748
name: negative regulation of tonic skeletal muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014746 ! regulation of tonic skeletal muscle contraction
is_a: GO:0045988 ! negative regulation of striated muscle contraction
relationship: negatively_regulates GO:0014720 ! tonic skeletal muscle contraction

[Term]
id: GO:0014801
name: longitudinal sarcoplasmic reticulum
namespace: cellular_component
def: "The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae." [GOC:mtg_muscle]
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0016529 ! sarcoplasmic reticulum

[Term]
id: GO:0014802
name: terminal cisterna
namespace: cellular_component
def: "The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release." [GOC:mtg_muscle]
xref: Wikipedia:Terminal_cisterna
is_a: GO:0031984 ! organelle subcompartment
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0016529 ! sarcoplasmic reticulum

[Term]
id: GO:0014803
name: longitudinal sarcoplasmic reticulum lumen
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of the longitudinal sarcoplasmic reticulum envelope. The longitudinal sarcoplasmic reticulum lumen is continuous with the lumen contained within the terminal cisternae." [GOC:mtg_muscle]
is_a: GO:0033018 ! sarcoplasmic reticulum lumen
relationship: part_of GO:0014801 ! longitudinal sarcoplasmic reticulum

[Term]
id: GO:0014804
name: terminal cisterna lumen
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of the terminal cisterna envelope. This space is enriched in calsequestrin." [GOC:mtg_muscle]
is_a: GO:0033018 ! sarcoplasmic reticulum lumen
relationship: part_of GO:0014802 ! terminal cisterna

[Term]
id: GO:0014805
name: smooth muscle adaptation
namespace: biological_process
def: "Any process by which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle]
synonym: "smooth muscle plasticity" RELATED []
is_a: GO:0043500 ! muscle adaptation

[Term]
id: GO:0014806
name: smooth muscle hyperplasia
namespace: biological_process
def: "A process, occurring in smooth muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ." [GOC:mtg_muscle]
is_a: GO:0014805 ! smooth muscle adaptation

[Term]
id: GO:0014807
name: regulation of somitogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of somitogenesis." [GOC:mtg_muscle]
is_a: GO:0045995 ! regulation of embryonic development
relationship: regulates GO:0001756 ! somitogenesis

[Term]
id: GO:0014808
name: release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
namespace: biological_process
def: "The process whereby the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels." [GOC:mtg_muscle]
synonym: "release of sequestered calcium ion by sarcoplasmic reticulum into cytosol" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051209 ! release of sequestered calcium ion into cytosol
is_a: GO:0070296 ! sarcoplasmic reticulum calcium ion transport

[Term]
id: GO:0014809
name: regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle, http://cancerweb.ncl.ac.uk]
is_a: GO:0010880 ! regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
is_a: GO:0014722 ! regulation of skeletal muscle contraction by calcium ion signaling

[Term]
id: GO:0014810
name: positive regulation of skeletal muscle contraction by regulation of the release of sequestered calcium ion
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle]
is_a: GO:0014809 ! regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
is_a: GO:0045989 ! positive regulation of striated muscle contraction

[Term]
id: GO:0014811
name: negative regulation of skeletal muscle contraction by regulation of the release of sequestered calcium ion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle]
is_a: GO:0014809 ! regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
is_a: GO:0045988 ! negative regulation of striated muscle contraction

[Term]
id: GO:0014812
name: muscle cell migration
namespace: biological_process
def: "The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000187, GOC:mtg_muscle]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0014813
name: satellite cell commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0048865 ! stem cell fate commitment
relationship: part_of GO:0014816 ! satellite cell differentiation

[Term]
id: GO:0014814
name: axon regeneration at neuromuscular junction
namespace: biological_process
def: "The regrowth of axons following their loss or damage at the neuromuscular junction. Motor axons regenerate after injury and they form neuro-muscular junctions with skeletal myofibers similar to normal ones." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0031103 ! axon regeneration

[Term]
id: GO:0014815
name: initiation of satellite cell activation by growth factor signalling, involved in skeletal muscle regeneration
namespace: biological_process
def: "Signalling between growth factors and their receptors that results in the activation of satellite cell, where this process is involved in skeletal muscle regeneration. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0014718 ! positive regulation of satellite cell activation involved in skeletal muscle regeneration

[Term]
id: GO:0014816
name: satellite cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0048863 ! stem cell differentiation
relationship: part_of GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0014817
name: satellite cell fate specification
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into a satellite cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0048866 ! stem cell fate specification
relationship: part_of GO:0014813 ! satellite cell commitment

[Term]
id: GO:0014818
name: satellite cell fate determination
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into a satellite cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0048867 ! stem cell fate determination
relationship: part_of GO:0014813 ! satellite cell commitment

[Term]
id: GO:0014819
name: regulation of skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0006942 ! regulation of striated muscle contraction
relationship: regulates GO:0003009 ! skeletal muscle contraction

[Term]
id: GO:0014820
name: tonic smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction." [GOC:mtg_muscle]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0014821
name: phasic smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations." [GOC:mtg_muscle]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0014822
name: detection of wounding
namespace: biological_process
def: "The series of events by which an injury stimulus is received and converted into a molecular signal." [GOC:mtg_muscle]
synonym: "detection of injury" EXACT []
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009611 ! response to wounding

[Term]
id: GO:0014823
name: response to activity
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus." [GOC:mtg_muscle]
synonym: "response to exercise" RELATED []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0014824
name: artery smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart." [GOC:mtg_muscle, MA:0000708, MESH:A07.231.114]
is_a: GO:0014820 ! tonic smooth muscle contraction
is_a: GO:0014829 ! vascular smooth muscle contraction

[Term]
id: GO:0014825
name: stomach fundus smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the fundus of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fundus is the portion of the stomach that lies above the cardiac notch." [GOC:mtg_muscle, http://cancerweb.ncl.ac.uk, MA:0001612]
is_a: GO:0014847 ! proximal stomach smooth muscle contraction

[Term]
id: GO:0014826
name: vein smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the vein. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The vein is a vessel carrying blood away from the capillary beds." [GOC:mtg_muscle, MA:0000715, MESH:A07.231.908]
is_a: GO:0014821 ! phasic smooth muscle contraction
is_a: GO:0014829 ! vascular smooth muscle contraction

[Term]
id: GO:0014827
name: intestine smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine." [GOC:mtg_muscle, MA:0001539, MESH:A03.556.124]
is_a: GO:0014821 ! phasic smooth muscle contraction
is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction

[Term]
id: GO:0014828
name: distal stomach smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The distal stomach is composed of the lower body and antrum and develops strong peristaltic phasic contractions that increase in amplitude as they propagate toward the pylorus." [GOC:mtg_muscle, http://biology.about.com]
is_a: GO:0014821 ! phasic smooth muscle contraction
is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction

[Term]
id: GO:0014829
name: vascular smooth muscle contraction
namespace: biological_process
def: "A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion." [GOC:mtg_muscle, MA:0002718]
is_a: GO:0006939 ! smooth muscle contraction
is_a: GO:0042310 ! vasoconstriction

[Term]
id: GO:0014830
name: arteriole smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the arteriole. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The arteriole is the smallest division of the artery located between the muscular arteries and the capillaries." [GOC:mtg_muscle, MA:0000706, MESH:A07.231.114.060]
is_a: GO:0014824 ! artery smooth muscle contraction

[Term]
id: GO:0014831
name: gastro-intestinal system smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract)." [GOC:mtg_muscle, MA:0001523, MESH:A03.556]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0014832
name: urinary bladder smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract." [GOC:mtg_muscle, MA:0001697, MESH:A05.810.890]
is_a: GO:0014848 ! urinary tract smooth muscle contraction

[Term]
id: GO:0014833
name: satellite cell asymmetric division
namespace: biological_process
def: "The asymmetric division of a satellite cell that occurs when a satellite cell divides to produce two daughter cells, one of which is destined to differentiate and the other to be a quiescent cell that restocks the satellite cell pool. Satellite cells are quiescent adult muscle stem cells that become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0008356 ! asymmetric cell division
relationship: part_of GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0014834
name: satellite cell maintenance involved in skeletal muscle regeneration
namespace: biological_process
def: "The process essential to maintain a ready source of satellite cells. It consists of the return of activated satellite cells to a quiescent state after proliferation to replenish the satellite cell pool. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb, PMID:16607119]
synonym: "satellite cell compartment self-renewal involved in skeletal muscle regeneration" EXACT [GOC:dph, GOC:tb]
synonym: "satellite cell population maintenance" EXACT []
synonym: "satellite cell self-renewal" BROAD []
is_a: GO:0035019 ! somatic stem cell maintenance
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014835
name: myoblast cell differentiation involved in skeletal muscle regeneration
namespace: biological_process
def: "The process whereby a relatively unspecialized satellite cell acquires specialized features of a myoblast cell. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0045445 ! myoblast differentiation
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014836
name: myoblast cell fate commitment involved in skeletal muscle regeneration
namespace: biological_process
def: "The process whereby the developmental fate of a satellite cell becomes restricted such that it will develop into a myoblast cell. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0048625 ! myoblast cell fate commitment
relationship: part_of GO:0014835 ! myoblast cell differentiation involved in skeletal muscle regeneration

[Term]
id: GO:0014837
name: myoblast cell fate determination involved in skeletal muscle regeneration
namespace: biological_process
def: "The process whereby a satellite cell becomes capable of differentiating autonomously into a myoblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0007518 ! myoblast cell fate determination
relationship: part_of GO:0014836 ! myoblast cell fate commitment involved in skeletal muscle regeneration

[Term]
id: GO:0014838
name: myoblast cell fate specification involved in skeletal muscle regeneration
namespace: biological_process
def: "The process whereby a satellite cell becomes capable of differentiating autonomously into a myoblast cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0048626 ! myoblast cell fate specification
relationship: part_of GO:0014836 ! myoblast cell fate commitment involved in skeletal muscle regeneration

[Term]
id: GO:0014839
name: myoblast migration involved in skeletal muscle regeneration
namespace: biological_process
def: "The process whereby a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
synonym: "mononucleate cell migration involved in skeletal muscle regeneration" BROAD []
is_a: GO:0051451 ! myoblast migration
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014841
name: satellite cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0014842
name: regulation of satellite cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of satellite cell proliferation." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0042127 ! regulation of cell proliferation
relationship: regulates GO:0014841 ! satellite cell proliferation

[Term]
id: GO:0014843
name: growth factor dependent regulation of satellite cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta." [GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0014842 ! regulation of satellite cell proliferation

[Term]
id: GO:0014844
name: myoblast cell proliferation involved in skeletal muscle regeneration
namespace: biological_process
def: "The multiplication or reproduction of myoblast cells, resulting in the expansion of the cell population. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119]
is_a: GO:0051450 ! myoblast proliferation
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014845
name: stomach body smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the body of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined." [GOC:ef, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk, MA:0002559]
is_a: GO:0014828 ! distal stomach smooth muscle contraction

[Term]
id: GO:0014846
name: esophagus smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the esophagus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The esophagus is the muscular membranous segment between the pharynx and the stomach in the upper gastrointestinal tract." [GOC:ef, GOC:mtg_muscle, MA:0001573, MESH:A03.556.875.500]
synonym: "oesophagus smooth muscle contraction" RELATED [GOC:dph]
is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction

[Term]
id: GO:0014847
name: proximal stomach smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the proximal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The proximal stomach, composed of the fundus and upper body, shows low frequency, sustained tonic contractions that are responsible for generating a basal pressure within the stomach." [GOC:mtg_muscle, http://biology.about.com]
is_a: GO:0014820 ! tonic smooth muscle contraction
is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction

[Term]
id: GO:0014848
name: urinary tract smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra." [GOC:ef, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk, MA:0000325, MESH:A05.810]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0014849
name: ureter smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the ureter. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_muscle, MA:0000378]
is_a: GO:0014821 ! phasic smooth muscle contraction
is_a: GO:0014848 ! urinary tract smooth muscle contraction

[Term]
id: GO:0014850
name: response to muscle activity
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus." [GOC:mtg_muscle]
is_a: GO:0014823 ! response to activity

[Term]
id: GO:0014852
name: regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014819 ! regulation of skeletal muscle contraction

[Term]
id: GO:0014853
name: regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction
namespace: biological_process
def: "Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0060079 ! regulation of excitatory postsynaptic membrane potential
relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction

[Term]
id: GO:0014854
name: response to inactivity
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus." [GOC:mtg_muscle]
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0014855
name: striated muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:ef, GOC:mtg_muscle]
is_a: GO:0033002 ! muscle cell proliferation

[Term]
id: GO:0014856
name: skeletal muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0014855 ! striated muscle cell proliferation

[Term]
id: GO:0014857
name: regulation of skeletal muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0042127 ! regulation of cell proliferation
relationship: regulates GO:0014856 ! skeletal muscle cell proliferation

[Term]
id: GO:0014858
name: positive regulation of skeletal muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation
relationship: positively_regulates GO:0014856 ! skeletal muscle cell proliferation

[Term]
id: GO:0014859
name: negative regulation of skeletal muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation
relationship: negatively_regulates GO:0014856 ! skeletal muscle cell proliferation

[Term]
id: GO:0014860
name: neurotransmitter secretion involved in regulation of skeletal muscle contraction
namespace: biological_process
def: "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GOC:dph, GOC:mtg_muscle, GOC:tb, http://cancerweb.ncl.ac.uk]
synonym: "neurotransmitter secretion involved in control of skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007269 ! neurotransmitter secretion
relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction

[Term]
id: GO:0014861
name: regulation of skeletal muscle contraction via membrane action potential
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes." [GOC:mtg_muscle]
is_a: GO:0014819 ! regulation of skeletal muscle contraction

[Term]
id: GO:0014862
name: regulation of skeletal muscle contraction by chemo-mechanical energy conversion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by regulating force and velocity of shortening. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through formation of cross bridges. The shortening leads to reduction of length of muscle fiber and sarcomeres." [GOC:mtg_muscle]
is_a: GO:0014819 ! regulation of skeletal muscle contraction

[Term]
id: GO:0014863
name: detection of inactivity
namespace: biological_process
def: "The series of events in which a inactivity stimulus is received by a cell or organism and converted into a molecular signal." [GOC:mtg_muscle]
is_a: GO:0014854 ! response to inactivity
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0014864
name: detection of muscle activity
namespace: biological_process
def: "The series of events in which a muscle activity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle]
is_a: GO:0014850 ! response to muscle activity
is_a: GO:0014865 ! detection of activity

[Term]
id: GO:0014865
name: detection of activity
namespace: biological_process
def: "The series of events in which an activity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle]
is_a: GO:0014823 ! response to activity
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0014866
name: skeletal myofibril assembly
namespace: biological_process
def: "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0030239 ! myofibril assembly

[Term]
id: GO:0014868
name: cross bridge cycling involved in regulation of the velocity of shortening in skeletal muscle contraction
namespace: biological_process
def: "A process whereby cross bridges are broken and reformed during filament sliding as part of the regulation of the velocity of shortening in skeletal muscle contraction." [GOC:mtg_muscle]
is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction

[Term]
id: GO:0014869
name: detection of muscle inactivity
namespace: biological_process
def: "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle]
is_a: GO:0014863 ! detection of inactivity
is_a: GO:0014870 ! response to muscle inactivity

[Term]
id: GO:0014870
name: response to muscle inactivity
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus." [GOC:mtg_muscle]
is_a: GO:0014854 ! response to inactivity

[Term]
id: GO:0014871
name: cross bridge formation involved in regulation of the velocity of shortening in skeletal muscle contraction
namespace: biological_process
def: "The process whereby actin and myosin interact, split ATP and generate force during skeletal muscle contraction. This process is one of the components of the regulation of the force of skeletal muscle contraction." [GOC:mtg_muscle]
is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction

[Term]
id: GO:0014872
name: myoblast cell division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle]
is_a: GO:0051301 ! cell division

[Term]
id: GO:0014873
name: response to muscle activity involved in regulation of muscle adaptation
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "response to fatigue" EXACT []
synonym: "response to muscle activity involved in regulation of muscle plasticity" RELATED []
is_a: GO:0014850 ! response to muscle activity
is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation

[Term]
id: GO:0014874
name: response to stimulus involved in regulation of muscle adaptation
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "response to stimulus involved in regulation of muscle plasticity" RELATED []
is_a: GO:0050896 ! response to stimulus
relationship: part_of GO:0043500 ! muscle adaptation

[Term]
id: GO:0014875
name: detection of muscle activity involved in regulation of muscle adaptation
namespace: biological_process
def: "The series of events by which a muscle activity stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "detection of fatigue" EXACT []
is_a: GO:0014864 ! detection of muscle activity
is_a: GO:0014873 ! response to muscle activity involved in regulation of muscle adaptation

[Term]
id: GO:0014876
name: response to injury involved in regulation of muscle adaptation
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a injury. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "response to injury involved in regulation of muscle plasticity" RELATED []
is_a: GO:0009611 ! response to wounding
is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation

[Term]
id: GO:0014877
name: response to muscle inactivity involved in regulation of muscle adaptation
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014870 ! response to muscle inactivity
is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation

[Term]
id: GO:0014878
name: response to electrical stimulus involved in regulation of muscle adaptation
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "response to electrical stimulus involved in regulation of muscle plasticity" RELATED []
is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation
is_a: GO:0051602 ! response to electrical stimulus

[Term]
id: GO:0014879
name: detection of electrical stimulus involved in regulation of muscle adaptation
namespace: biological_process
def: "The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014878 ! response to electrical stimulus involved in regulation of muscle adaptation
is_a: GO:0050981 ! detection of electrical stimulus

[Term]
id: GO:0014880
name: regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction." [GOC:dph, GOC:mtg_muscle, GOC:tb]
is_a: GO:0032971 ! regulation of muscle filament sliding
relationship: part_of GO:0014729 ! regulation of the velocity of shortening of skeletal muscle during contraction

[Term]
id: GO:0014881
name: regulation of myofibril size
namespace: biological_process
def: "Any process that modulates the size of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb]
synonym: "change of myofibril size" EXACT []
is_a: GO:0014743 ! regulation of muscle hypertrophy
is_a: GO:0090066 ! regulation of anatomical structure size

[Term]
id: GO:0014882
name: regulation of myofibril number
namespace: biological_process
def: "Any process that modulates the number of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb]
synonym: "change of myofibril number" EXACT []
is_a: GO:0014738 ! regulation of muscle hyperplasia
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0014883
name: transition between fast and slow fiber
namespace: biological_process
def: "The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation." [GOC:ef, GOC:mtg_muscle]
synonym: "transition between fast and slow fibre" EXACT []
synonym: "transition fast-slow fiber" EXACT []
synonym: "transition fast-slow fibre" EXACT []
is_a: GO:0014733 ! regulation of skeletal muscle adaptation

[Term]
id: GO:0014884
name: detection of muscle inactivity involved in regulation of muscle adaptation
namespace: biological_process
def: "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
is_a: GO:0014869 ! detection of muscle inactivity
is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation

[Term]
id: GO:0014885
name: detection of injury involved in regulation of muscle adaptation
namespace: biological_process
def: "The series of events by which an injury stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle]
synonym: "detection of injury involved in regulation of muscle plasticity" RELATED []
is_a: GO:0014822 ! detection of wounding
is_a: GO:0014876 ! response to injury involved in regulation of muscle adaptation

[Term]
id: GO:0014886
name: transition between slow and fast fiber
namespace: biological_process
def: "The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation." [GOC:ef, GOC:mtg_muscle]
synonym: "transition between slow and fast fibre" EXACT []
synonym: "transition slow-fast fiber" EXACT []
synonym: "transition slow-fast fibre" EXACT []
is_a: GO:0014733 ! regulation of skeletal muscle adaptation

[Term]
id: GO:0014887
name: cardiac muscle adaptation
namespace: biological_process
def: "The process by which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle]
synonym: "cardiac muscle plasticity" RELATED []
is_a: GO:0014888 ! striated muscle adaptation

[Term]
id: GO:0014888
name: striated muscle adaptation
namespace: biological_process
def: "Any process by which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle]
synonym: "striated muscle plasticity" RELATED []
is_a: GO:0043500 ! muscle adaptation

[Term]
id: GO:0014889
name: muscle atrophy
namespace: biological_process
def: "A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle]
xref: Wikipedia:Muscle_atrophy
is_a: GO:0043500 ! muscle adaptation

[Term]
id: GO:0014890
name: smooth muscle atrophy
namespace: biological_process
def: "A process, occurring in smooth muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle]
is_a: GO:0014805 ! smooth muscle adaptation
is_a: GO:0014889 ! muscle atrophy

[Term]
id: GO:0014891
name: striated muscle atrophy
namespace: biological_process
def: "A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle]
is_a: GO:0014888 ! striated muscle adaptation
is_a: GO:0014889 ! muscle atrophy

[Term]
id: GO:0014893
name: response to rest involved in regulation of muscle adaptation
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rest stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:mtg_muscle]
is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation

[Term]
id: GO:0014894
name: response to denervation involved in regulation of muscle adaptation
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:mtg_muscle]
is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation

[Term]
id: GO:0014895
name: smooth muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy." [GOC:mtg_muscle]
is_a: GO:0014805 ! smooth muscle adaptation
is_a: GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014896
name: muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of an organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy." [GOC:mtg_muscle, http://cancerweb.ncl.ac.uk]
xref: Wikipedia:Muscle_hypertrophy
is_a: GO:0003012 ! muscle system process

[Term]
id: GO:0014897
name: striated muscle hypertrophy
namespace: biological_process
def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle]
is_a: GO:0014896 ! muscle hypertrophy

[Term]
id: GO:0014898
name: cardiac muscle hypertrophy in response to stress
namespace: biological_process
def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:mtg_muscle]
is_a: GO:0003299 ! muscle hypertrophy in response to stress
is_a: GO:0003300 ! cardiac muscle hypertrophy
is_a: GO:0014887 ! cardiac muscle adaptation

[Term]
id: GO:0014899
name: cardiac muscle atrophy
namespace: biological_process
def: "A process, occurring in the heart, in which a decrease in cell mass and then in heart size occurs due to shrinking of the individual cells. The shrinkage is caused by protein degradation." [GOC:mtg_muscle]
is_a: GO:0014887 ! cardiac muscle adaptation
is_a: GO:0014891 ! striated muscle atrophy

[Term]
id: GO:0014900
name: muscle hyperplasia
namespace: biological_process
def: "A process, occurring in muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ." [GOC:mtg_muscle, http://cancerweb.ncl.ac.uk]
is_a: GO:0043500 ! muscle adaptation

[Term]
id: GO:0014901
name: satellite cell activation involved in skeletal muscle regeneration
namespace: biological_process
def: "The process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle]
is_a: GO:0014719 ! satellite cell activation
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014902
name: myotube differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]
is_a: GO:0042692 ! muscle cell differentiation
relationship: part_of GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0014904
name: myotube cell development
namespace: biological_process
def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0014902 ! myotube differentiation

[Term]
id: GO:0014905
name: myoblast fusion involved in skeletal muscle regeneration
namespace: biological_process
def: "A process whereby non-proliferating myoblasts, after migrating to the site of injury, fuse into existing damaged fibers or fuse to myotubes to form new fibers, as part of the process of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk/]
is_a: GO:0007520 ! myoblast fusion
relationship: part_of GO:0014908 ! myotube differentiation involved in skeletal muscle regeneration

[Term]
id: GO:0014906
name: myotube cell development involved in skeletal muscle regeneration
namespace: biological_process
def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. This occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]
is_a: GO:0014904 ! myotube cell development
relationship: part_of GO:0014908 ! myotube differentiation involved in skeletal muscle regeneration

[Term]
id: GO:0014908
name: myotube differentiation involved in skeletal muscle regeneration
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. This process occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle]
is_a: GO:0014902 ! myotube differentiation
relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0014909
name: smooth muscle cell migration
namespace: biological_process
def: "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0014812 ! muscle cell migration

[Term]
id: GO:0014910
name: regulation of smooth muscle cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0014909 ! smooth muscle cell migration

[Term]
id: GO:0014911
name: positive regulation of smooth muscle cell migration
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
is_a: GO:0030335 ! positive regulation of cell migration
relationship: positively_regulates GO:0014909 ! smooth muscle cell migration

[Term]
id: GO:0014912
name: negative regulation of smooth muscle cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
is_a: GO:0030336 ! negative regulation of cell migration
relationship: negatively_regulates GO:0014909 ! smooth muscle cell migration

[Term]
id: GO:0014914
name: myoblast maturation involved in muscle regeneration
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast cell to attain its fully functional state involved in muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle]
is_a: GO:0048628 ! myoblast maturation

[Term]
id: GO:0014915
name: regulation of muscle filament sliding speed involved in regulation of the velocity of shortening in skeletal muscle contraction
namespace: biological_process
def: "Any process that modulates the velocity of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction." [GOC:dph, GOC:mtg_muscle, GOC:tb]
is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction
is_a: GO:0032972 ! regulation of muscle filament sliding speed

[Term]
id: GO:0014916
name: regulation of lung blood pressure
namespace: biological_process
def: "The process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio]
synonym: "regulation of pulmonary blood pressure" EXACT []
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0014917
name: positive regulation of diuresis by pressure natriuresis
namespace: biological_process
def: "The process by which pressure natriuresis increases the rate of diuresis." [GOC:mtg_cardio]
is_a: GO:0003103 ! positive regulation of diuresis
relationship: part_of GO:0003095 ! pressure natriuresis

[Term]
id: GO:0014918
name: positive regulation of natriuresis by pressure natriuresis
namespace: biological_process
def: "The process whereby pressure natriuresis increases rate of natriuresis." [GOC:mtg_cardio]
is_a: GO:0003079 ! positive regulation of natriuresis
relationship: part_of GO:0003095 ! pressure natriuresis

[Term]
id: GO:0015000
name: polyferredoxin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a function.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015001
name: high-potential iron-sulfur carrier
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
synonym: "high-potential iron-sulphur carrier" EXACT []
synonym: "HiPIP" RELATED []
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015002
name: heme-copper terminal oxidase activity
namespace: molecular_function
def: "Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane." [GOC:kd]
subset: gosubset_prok
synonym: "haem-copper terminal oxidase activity" EXACT []
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0015003
name: copper electron carrier
namespace: molecular_function
def: "OBSOLETE. A copper-containing entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai]
comment: This term was made obsolete because it refers to a class of gene products.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015004
name: small blue copper electron carrier
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015005
name: azurin
namespace: molecular_function
def: "OBSOLETE. Brilliant blue copper-containing protein of low molecular weight found in some bacteria; thought to transfer electrons to cytochrome oxidase. This definition includes pseudoazurin." [ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0015006
name: plastocyanin
namespace: molecular_function
def: "OBSOLETE. A copper-containing electron carrier acting between cytochrome b(6)-f and P700 of photosystem I." [ISBN:0198547684]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
replaced_by: GO:0046028

[Term]
id: GO:0015007
name: electron carrier, chlorophyll electron transport system
namespace: molecular_function
def: "OBSOLETE. A molecular entity that serves as an electron acceptor and electron donor in a chlorophyll electron transport system." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it contains both process and function information.
synonym: "chlorophyll electron carrier" RELATED []
is_obsolete: true
consider: GO:0009055
consider: GO:0009767

[Term]
id: GO:0015009
name: corrin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "corrin metabolism" EXACT []
is_a: GO:0033013 ! tetrapyrrole metabolic process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0015010
name: tetrahydrocorphin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrahydrocorphins, tetrapyrroles that combine the structural elements of both porphyrins and corrins." [http://findarticles.com/p/articles/mi_m0841/is_n1_v28/ai_13746418, http://www.chem.qmul.ac.uk/iupac/bioinorg/CD.html#44]
subset: gosubset_prok
synonym: "tetrahydrocorphin metabolism" EXACT []
is_a: GO:0033013 ! tetrapyrrole metabolic process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0015011
name: nickel-tetrapyrrole coenzyme metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an enzyme cofactor consisting of a tetrapyrrole structure containing nickel, such as the F-430 cofactor found in methyl-coenzyme M reductase." [GOC:mah, http://www.chem.qmul.ac.uk/iupac/bioinorg/CD.html#44, http://www.chem.qmul.ac.uk/iupac/bioinorg/EG.html#33]
subset: gosubset_prok
synonym: "coenzyme F430 metabolic process" NARROW []
synonym: "nickel-tetrapyrrole coenzyme metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0015010 ! tetrahydrocorphin metabolic process

[Term]
id: GO:0015012
name: heparan sulfate proteoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0198547684, RESID:AA0210]
subset: gosubset_prok
synonym: "heparan sulfate proteoglycan anabolism" EXACT []
synonym: "heparan sulfate proteoglycan biosynthesis" EXACT []
synonym: "heparan sulfate proteoglycan formation" EXACT []
synonym: "heparan sulfate proteoglycan synthesis" EXACT []
synonym: "heparan sulphate proteoglycan biosynthesis" EXACT []
synonym: "heparan sulphate proteoglycan biosynthetic process" EXACT []
synonym: "heparin proteoglycan biosynthetic process" RELATED []
xref: RESID:AA0210
is_a: GO:0030166 ! proteoglycan biosynthetic process
is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0015013
name: heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide
namespace: biological_process
def: "The polymerization of one or more heparan sulfate chains via a xylose link onto serine residues in the core protein of a proteoglycan." [ISBN:0815316194]
subset: gosubset_prok
synonym: "heparan sulfate proteoglycan anabolism, linkage to polypeptide" EXACT []
synonym: "heparan sulfate proteoglycan formation, linkage to polypeptide" EXACT []
synonym: "heparan sulfate proteoglycan synthesis, linkage to polypeptide" EXACT []
synonym: "heparan sulphate proteoglycan biosynthesis, linkage to polypeptide" EXACT []
synonym: "heparan sulphate proteoglycan biosynthetic process, linkage to polypeptide" EXACT []
synonym: "heparin proteoglycan biosynthetic process, linkage to polypeptide" RELATED []
is_a: GO:0018242 ! protein amino acid O-linked glycosylation via serine
is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process
relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0015014
name: heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan." [GOC:ai]
subset: gosubset_prok
synonym: "heparan sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT []
synonym: "heparan sulfate proteoglycan chain elongation" EXACT []
synonym: "heparan sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT []
synonym: "heparan sulfate proteoglycan formation, polysaccharide chain formation" EXACT []
synonym: "heparan sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT []
synonym: "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT []
synonym: "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT []
synonym: "heparin proteoglycan biosynthetic process, polysaccharide chain biosynthetic process" RELATED []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0015015
name: heparan sulfate proteoglycan biosynthetic process, enzymatic modification
namespace: biological_process
def: "The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization." [ISBN:0815316194]
subset: gosubset_prok
synonym: "heparan sulfate proteoglycan anabolism, enzymatic modification" EXACT []
synonym: "heparan sulfate proteoglycan formation, enzymatic modification" EXACT []
synonym: "heparan sulfate proteoglycan synthesis, enzymatic modification" EXACT []
synonym: "heparan sulphate proteoglycan biosynthesis, enzymatic modification" EXACT []
synonym: "heparan sulphate proteoglycan biosynthetic process, enzymatic modification" EXACT []
synonym: "heparin proteoglycan biosynthetic process, enzymatic modification" RELATED []
is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process
relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0015016
name: [heparan sulfate]-glucosamine N-sulfotransferase activity
namespace: molecular_function
alt_id: GO:0004393
alt_id: GO:0015022
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-desulfoheparin = adenosine 3',5'-bisphosphate + heparin." [EC:2.8.2.8]
comment: Note that this activity includes EC:2.8.2.12 (deleted from EC).
synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "[heparan sulphate]-glucosamine N-sulphotransferase activity" EXACT []
synonym: "desulfoheparin sulfotransferase activity" EXACT []
synonym: "glucosaminyl N-deacetylase/N-sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "heparan sulfate 2-N-sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "heparan sulfate N-deacetylase/N-sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "heparan sulfate N-sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "heparin N-deacetylase/N-sulfotransferase activity" RELATED []
synonym: "heparin N-deacetylase/N-sulphotransferase activity" RELATED []
synonym: "heparin N-sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "heparin-glucosamine N-sulfotransferase activity" EXACT []
synonym: "N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "N-heparan sulfate sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "N-HSST activity" EXACT [EC:2.8.2.8]
synonym: "PAPS:DSH sulfotransferase activity" EXACT [EC:2.8.2.8]
synonym: "PAPS:N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8]
xref: EC:2.8.2.8
xref: MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0015017
name: glypican
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product (was misspelled 'glycipan').
is_obsolete: true

[Term]
id: GO:0015018
name: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135]
synonym: "glucuronosyltransferase I activity" NARROW [EC:2.4.1.135]
synonym: "UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" EXACT [EC:2.4.1.135]
synonym: "UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" EXACT [EC:2.4.1.135]
synonym: "uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase activity" EXACT [EC:2.4.1.135]
xref: EC:2.4.1.135
xref: MetaCyc:2.4.1.135-RXN
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0015019
name: heparan-alpha-glucosaminide N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide." [EC:2.3.1.78]
synonym: "acetyl-CoA:alpha-glucosaminide N-acetyltransferase activity" EXACT [EC:2.3.1.78]
synonym: "acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase activity" EXACT [EC:2.3.1.78]
synonym: "heparin-alpha-glucosaminide N-acetyltransferase activity" RELATED []
xref: EC:2.3.1.78
xref: MetaCyc:2.3.1.78-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0015020
name: glucuronosyltransferase activity
namespace: molecular_function
alt_id: GO:0003981
def: "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17]
synonym: "1-naphthol glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "1-naphthol-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "17-OH steroid UDPGT activity" NARROW [EC:2.4.1.17]
synonym: "17beta-hydroxysteroid UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "3-OH androgenic UDPGT activity" NARROW [EC:2.4.1.17]
synonym: "3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "4-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "4-nitrophenol UDPGT activity" NARROW [EC:2.4.1.17]
synonym: "bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "bilirubin monoglucuronide glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "bilirubin UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "bilirubin UDPGT activity" NARROW [EC:2.4.1.17]
synonym: "bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "ciramadol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "estriol UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "estrone UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "GT activity" EXACT [EC:2.4.1.17]
synonym: "morphine glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "p-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "p-nitrophenylglucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "p-phenylphenol glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "phenyl-UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "Phenyl-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "PNP-UDPGT" RELATED [EC:2.4.1.17]
synonym: "pnp-UDPGT activity" NARROW [EC:2.4.1.17]
synonym: "UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "UDP glucuronic acid transferase activity" EXACT [EC:2.4.1.17]
synonym: "UDP glucuronosyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "UDP glucuronyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [EC:2.4.1.17]
synonym: "UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "UDP-glucuronyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "UDPGA transferase activity" EXACT [EC:2.4.1.17]
synonym: "UDPGA-glucuronyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" EXACT [EC:2.4.1.17]
synonym: "UDPGT activity" EXACT [EC:2.4.1.17]
synonym: "uridine 5'-diphosphoglucuronyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "uridine diphosphate glucuronyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronosyltransferase activity" EXACT [EC:2.4.1.17]
synonym: "uridine diphosphoglucuronyltransferase activity" EXACT [EC:2.4.1.17]
xref: EC:2.4.1.17
xref: MetaCyc:UDP-GLUCURONOSYLTRANSFERASE-RXN
xref: Reactome:9978 "glucuronosyltransferase activity"
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0015021
name: heparin-sulfate lyase activity
namespace: molecular_function
def: "Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar." [EC:4.2.2.8]
subset: gosubset_prok
synonym: "[heparan sulfate]-sulfate lyase activity" RELATED []
synonym: "heparin-sulfate eliminase activity" RELATED [EC:4.2.2.8]
synonym: "heparin-sulphate lyase activity" EXACT []
synonym: "heparitin-sulfate lyase activity" EXACT []
synonym: "heparitinase I" RELATED [EC:4.2.2.8]
synonym: "heparitinase II" RELATED [EC:4.2.2.8]
xref: EC:4.2.2.8
xref: MetaCyc:4.2.2.8-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0015023
name: syndecan
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true

[Term]
id: GO:0015024
name: glucuronate-2-sulfatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate." [EC:3.1.6.18]
synonym: "chondro-2-sulfatase activity" EXACT [EC:3.1.6.18]
synonym: "glucuronate-2-sulphatase activity" EXACT []
synonym: "glucurono-2-sulfatase activity" EXACT [EC:3.1.6.18]
synonym: "polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase activity" EXACT [EC:3.1.6.18]
xref: EC:3.1.6.18
xref: MetaCyc:3.1.6.18-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0015025
name: GPI-anchored membrane-bound receptor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
is_obsolete: true
replaced_by: GO:0031225
consider: GO:0004872

[Term]
id: GO:0015026
name: coreceptor activity
namespace: molecular_function
def: "Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators]
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0015027
name: coreceptor, soluble ligand activity
namespace: molecular_function
is_a: GO:0015026 ! coreceptor activity

[Term]
id: GO:0015028
name: coreceptor, insoluble ligand activity
namespace: molecular_function
is_a: GO:0015026 ! coreceptor activity

[Term]
id: GO:0015029
name: internalization receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because internalization is a process, not a ligand to which a receptor might bind.
is_obsolete: true

[Term]
id: GO:0015030
name: Cajal body
namespace: cellular_component
def: "A class of nuclear body, first seen after silver staining by Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [http://genetics.cwru.edu/matera3.html, PMID:10944589, PMID:11031238, PMID:7559785]
synonym: "coiled body" EXACT []
synonym: "Gems" EXACT []
xref: Wikipedia:Cajal_body
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0015031
name: protein transport
namespace: biological_process
alt_id: GO:0015831
def: "The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
synonym: "enzyme transport" NARROW []
is_a: GO:0006810 ! transport
is_a: GO:0045184 ! establishment of protein localization

[Term]
id: GO:0015032
name: storage protein import into fat body
namespace: biological_process
def: "The incorporation of hemolymph proteins by cells of the fat body of holometabolous insects, during the final larval stage. Uptake of these proteins prepares the insect for pupation and metamorphosis, since insect pupae do not feed and therefore depend on material that has been accumulated during larval life." [GOC:bf, PMID:10231363]
synonym: "fat body metabolic process" BROAD []
synonym: "fat body metabolism" BROAD []
synonym: "fat body storage protein uptake" EXACT []
synonym: "import of storage protein into fat body" EXACT []
synonym: "storage protein import by fat body cells" EXACT []
synonym: "storage protein import into fat body cells" EXACT []
synonym: "storage protein transport into fat body cells" EXACT []
synonym: "storage protein uptake into fat body cells" EXACT []
is_a: GO:0017038 ! protein import

[Term]
id: GO:0015034
name: cytochrome P450 activity
namespace: molecular_function
def: "OBSOLETE. A cytochrome b-like protein that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes: typically monooxygenases acting on, typically, lipophilic substrates. The characteristic mode of action of these enzymes is not electron transfer (some P450 enzymes probably do not even involve the reversible Fe(II)/Fe(III) equilibrium), but rather oxygen atom transfer." [ISBN:0198547684, PMID:1655423]
comment: This term was made obsolete because it is a grouping term representing a set of gene products.
is_obsolete: true
consider: GO:0019825

[Term]
id: GO:0015035
name: protein disulfide oxidoreductase activity
namespace: molecular_function
alt_id: GO:0008895
def: "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN]
subset: gosubset_prok
synonym: "haem lyase disulphide oxidoreductase activity" NARROW []
synonym: "heme lyase disulfide oxidoreductase activity" NARROW []
synonym: "protein disulphide oxidoreductase activity" EXACT []
synonym: "thioredoxin activity" NARROW [GOC:mah, GOC:vw]
xref: MetaCyc:DISULFOXRED-RXN
is_a: GO:0015036 ! disulfide oxidoreductase activity

[Term]
id: GO:0015036
name: disulfide oxidoreductase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction that interconverts reduced sulfide groups and oxidized disulfide bonds in a substrate." [GOC:mah, MetaCyc:DISULFOXRED-RXN]
subset: gosubset_prok
synonym: "disulphide oxidoreductase activity" EXACT []
xref: Reactome:10513 "disulfide oxidoreductase activity"
is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors

[Term]
id: GO:0015037
name: peptide disulfide oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide bonds." [GOC:mah, MetaCyc:DISULFOXRED-RXN-]
subset: gosubset_prok
synonym: "peptide disulphide oxidoreductase activity" EXACT []
is_a: GO:0015036 ! disulfide oxidoreductase activity

[Term]
id: GO:0015038
name: glutathione disulfide oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor." [GOC:mah]
subset: gosubset_prok
synonym: "glutaredoxin" RELATED []
synonym: "glutathione disulphide oxidoreductase activity" EXACT []
is_a: GO:0015037 ! peptide disulfide oxidoreductase activity

[Term]
id: GO:0015039
name: NADPH-adrenodoxin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+." [EC:1.18.1.2, GOC:kd]
comment: Note that this term specifically refers to the reaction proceeding in the direction shown; under physiological conditions adrenodoxin reduction by adrenodoxin reductase is coupled with electron transfer from AdR to P450, which catalyzes an irreversible monooxygenation reaction. This term should therefore be used to annotate gene products that catalyze the reduction of oxidized adrenodoxin; also consider annotating to the molecular function term 'ferredoxin-NADP+ reductase activity ; GO:0004324'.
synonym: "adrenodoxin reductase activity" BROAD [EC:1.18.1.2]
synonym: "adrenodoxin-type ferredoxin reductase activity" EXACT [GOC:kd]
synonym: "NADPH:adrenodoxin oxidoreductase activity" EXACT [EC:1.18.1.2]
xref: EC:1.18.1.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0015040
name: electron transfer flavoprotein, group I
namespace: molecular_function
def: "OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that links acyl-CoA dehydrogenase reactions with the respiratory chain, such as in the fatty acid degradation pathway." [PMID:8599534]
comment: This term was made obsolete because it refers to a class of gene products.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015041
name: electron transfer flavoprotein, group II
namespace: molecular_function
def: "OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that is synthesized only under certain specific growth conditions and receives electrons from the oxidation of specific substrates, e.g. trimethylamine, carnitine and in nitrogen fixation." [PMID:8599534]
comment: This term was made obsolete because it refers to a class of gene products.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015042
name: trypanothione-disulfide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide." [EC:1.8.1.12]
comment: Note that this function was formerly EC:1.6.4.8.
synonym: "N(1),N(8)-bis(glutathionyl)spermidine reductase activity" EXACT [EC:1.8.1.12]
synonym: "N1,N8-bis(glutathionyl)spermidine reductase activity" EXACT [EC:1.8.1.12]
synonym: "NADPH2:trypanothione oxidoreductase activity" EXACT [EC:1.8.1.12]
synonym: "NADPH:trypanothione oxidoreductase activity" EXACT [EC:1.8.1.12]
synonym: "trypanothione reductase activity" EXACT []
synonym: "trypanothione-disulphide reductase activity" EXACT []
synonym: "trypanothione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.12]
xref: EC:1.8.1.12
xref: MetaCyc:1.8.1.12-RXN
is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor

[Term]
id: GO:0015043
name: leghemoglobin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin." [EC:1.6.2.6]
synonym: "ferric leghemoglobin reductase activity" EXACT [EC:1.6.2.6]
synonym: "NAD(P)H:ferrileghemoglobin oxidoreductase activity" EXACT [EC:1.6.2.6]
xref: EC:1.6.2.6
xref: MetaCyc:LEGHEMOGLOBIN-REDUCTASE-RXN
is_a: GO:0016653 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor

[Term]
id: GO:0015044
name: rubredoxin-NAD+ reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+." [EC:1.18.1.1]
subset: gosubset_prok
synonym: "dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity" EXACT [EC:1.18.1.1]
synonym: "DPNH-rubredoxin reductase activity" EXACT [EC:1.18.1.1]
synonym: "NADH--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.1]
synonym: "NADH--rubredoxin reductase activity" EXACT [EC:1.18.1.1]
synonym: "NADH:rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.1]
synonym: "NADH:rubredoxin reductase activity" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide--rubredoxin reductase activity" EXACT [EC:1.18.1.1]
synonym: "rubredoxin--NAD reductase activity" EXACT [EC:1.18.1.1]
synonym: "rubredoxin--nicotinamide adenine dinucleotide reductase activity" EXACT [EC:1.18.1.1]
synonym: "rubredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.1]
xref: EC:1.18.1.1
xref: MetaCyc:RUBREDOXIN--NAD+-REDUCTASE-RXN
is_a: GO:0015046 ! rubredoxin reductase activity

[Term]
id: GO:0015045
name: rubredoxin-NAD(P)+ reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+." [EC:1.18.1.4]
synonym: "dinucleotide phosphate reductase activity" RELATED [EC:1.18.1.4]
synonym: "NAD(P)--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.4]
synonym: "NAD(P)H--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.4]
synonym: "NADPH:rubredoxin reductase activity" EXACT []
synonym: "rubredoxin--nicotinamide adenine activity" RELATED [EC:1.18.1.4]
synonym: "rubredoxin--nicotinamide adenine dinucleotide (phosphate) reductase activity" EXACT [EC:1.18.1.4]
synonym: "rubredoxin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.18.1.4]
xref: EC:1.18.1.4
xref: MetaCyc:RUBREDOXIN--NADP+-REDUCTASE-RXN
is_a: GO:0015046 ! rubredoxin reductase activity

[Term]
id: GO:0015046
name: rubredoxin reductase activity
namespace: molecular_function
def: "Catalysis of the reactions: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+." [EC:1.18.1.-]
subset: gosubset_prok
xref: EC:1.18.1.-
xref: MetaCyc:RUBREDOXIN--NAD+-REDUCTASE-RXN
is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor

[Term]
id: GO:0015047
name: NADPH-cytochrome-c2 reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2." [EC:1.6.2.5]
synonym: "cytochrome c2 reductase (reduced nicotinamide adinine dinucleotide phosphate, NADPH)" EXACT [EC:1.6.2.5]
synonym: "NADPH:ferricytochrome-c2 oxidoreductase activity" EXACT [EC:1.6.2.5]
synonym: "reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.6.2.5]
xref: EC:1.6.2.5
xref: MetaCyc:NADPH--CYTOCHROME-C2-REDUCTASE-RXN
is_a: GO:0016653 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor

[Term]
id: GO:0015048
name: phthalate dioxygenase reductase activity
namespace: molecular_function
def: "Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems." [PMID:7589982]
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0015049
name: methane monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O." [EC:1.14.13.25]
subset: gosubset_prok
synonym: "methane hydroxylase activity" EXACT [EC:1.14.13.25]
synonym: "methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.25]
xref: EC:1.14.13.25
xref: MetaCyc:METHANE-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0007
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0015050
name: methane monooxygenase complex
namespace: cellular_component
def: "A protein complex that possesses methane monooxygenase activity; dimeric and trimeric complexes have been characterized." [BRENDA:1.14.13.25, GOC:mah]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0015051
name: X-opioid receptor activity
namespace: molecular_function
is_a: GO:0004985 ! opioid receptor activity

[Term]
id: GO:0015052
name: beta3-adrenergic receptor activity
namespace: molecular_function
def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274]
synonym: "beta3 adrenoceptor" EXACT []
is_a: GO:0004939 ! beta-adrenergic receptor activity

[Term]
id: GO:0015053
name: opsin
namespace: molecular_function
def: "OBSOLETE. Hydrophobic glycoprotein to which 11-cis-retinal binds as a Schiff base (in rhodopsin) or 3,4-didehydro-11-cis-retinal binds as a Schiff base in cyanopsin and porphyropsin." [ISBN:0198547684]
comment: This term was made obsolete because it refers to a class of proteins.
is_obsolete: true
consider: GO:0007602
consider: GO:0009881
consider: GO:0016021
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015054
name: gastrin receptor activity
namespace: molecular_function
def: "Combining with gastrin to initiate a change in cell activity." [GOC:ai]
synonym: "cholecystokinin-B receptor activity" EXACT []
is_a: GO:0004951 ! cholecystokinin receptor activity

[Term]
id: GO:0015055
name: secretin receptor activity
namespace: molecular_function
def: "Combining with secretin to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0015056
name: corticotrophin-releasing factor receptor activity
namespace: molecular_function
def: "Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity." [PMID:12032352]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0015057
name: thrombin receptor activity
namespace: molecular_function
alt_id: GO:0010655
def: "Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state." [GOC:ai]
synonym: "thrombin receptor activity, G-protein coupled" EXACT []
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0015058
name: epidermal growth factor-like module containing hormone receptor activity
namespace: molecular_function
alt_id: GO:0016523
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features.
synonym: "EGF-like module containing hormone receptor activity" EXACT []
synonym: "Egr1 hormone receptor" EXACT []
is_obsolete: true

[Term]
id: GO:0015059
name: blue-sensitive opsin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of proteins.
is_obsolete: true
consider: GO:0007603
consider: GO:0009588
consider: GO:0009881
consider: GO:0016021
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015060
name: green-sensitive opsin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of proteins.
is_obsolete: true
consider: GO:0007603
consider: GO:0009881
consider: GO:0016021
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015061
name: red-sensitive opsin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of proteins.
is_obsolete: true
consider: GO:0007603
consider: GO:0009585
consider: GO:0009881
consider: GO:0016021
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015062
name: violet-sensitive opsin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it refers to a class of proteins.
is_obsolete: true
consider: GO:0007603
consider: GO:0009588
consider: GO:0009881
consider: GO:0016021
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015063
name: long-wave-sensitive opsin
namespace: molecular_function
def: "OBSOLETE. An opsin with maximal absorption above 500 nm." [PMID:10594055]
comment: This term was made obsolete because it refers to a class of proteins.
is_obsolete: true
consider: GO:0007603
consider: GO:0009881
consider: GO:0016021
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015064
name: UV-sensitive opsin
namespace: molecular_function
def: "OBSOLETE. An opsin with maximal absorption below 400 nm." [PMID:10594055]
comment: This term was made obsolete because it refers to a class of proteins.
is_obsolete: true
consider: GO:0007604
consider: GO:0009881
consider: GO:0016021
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0015065
name: uridine nucleotide receptor activity
namespace: molecular_function
def: "Combining with UTP or UDP to initiate a change in cell activity." [GOC:curators, PMID:8537335]
synonym: "purinoceptor type U" EXACT []
is_a: GO:0071553 ! pyrimidinergic nucleotide receptor activity, G-protein coupled

[Term]
id: GO:0015066
name: alpha-amylase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of alpha-amylase." [GOC:mah]
subset: gosubset_prok
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0015067
name: amidinotransferase activity
namespace: molecular_function
def: "Catalysis of the reversible transfer of an amidino group to an acceptor." [GOC:ai]
subset: gosubset_prok
synonym: "transamidinase activity" EXACT []
xref: EC:2.1.4.-
is_a: GO:0016741 ! transferase activity, transferring one-carbon groups
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups

[Term]
id: GO:0015068
name: glycine amidinotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate." [EC:2.1.4.1]
subset: gosubset_prok
synonym: "arginine-glycine amidinotransferase activity" EXACT [EC:2.1.4.1]
synonym: "arginine-glycine transamidinase activity" EXACT [EC:2.1.4.1]
synonym: "glycine transamidinase activity" EXACT [EC:2.1.4.1]
synonym: "L-arginine:glycine amidinotransferase activity" EXACT [EC:2.1.4.1]
xref: EC:2.1.4.1
xref: MetaCyc:GLYCINE-AMIDINOTRANSFERASE-RXN
xref: Reactome:19902 "glycine amidinotransferase activity"
is_a: GO:0015067 ! amidinotransferase activity

[Term]
id: GO:0015069
name: scyllo-inosamine-4-phosphate amidinotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate = L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate." [EC:2.1.4.2]
subset: gosubset_prok
synonym: "inosamine-P amidinotransferase activity" EXACT [EC:2.1.4.2]
synonym: "inosamine-phosphate amidinotransferase activity" EXACT []
synonym: "L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase activity" EXACT [EC:2.1.4.2]
synonym: "L-arginine:inosamine phosphate amidinotransferase activity" EXACT [EC:2.1.4.2]
synonym: "L-arginine:inosamine-P-amidinotransferase activity" EXACT [EC:2.1.4.2]
xref: EC:2.1.4.2
xref: MetaCyc:2.1.4.2-RXN
is_a: GO:0015067 ! amidinotransferase activity

[Term]
id: GO:0015070
name: toxin activity
namespace: molecular_function
def: "OBSOLETE. Acts as to cause injury to other living organisms." [GOC:jl, http://cancerweb.ncl.ac.uk/]
comment: This term was made obsolete because it represents a classification of molecules and not a molecular function.
is_obsolete: true
consider: GO:0009405
consider: GO:0050827

[Term]
id: GO:0015072
name: phosphatidylinositol 3-kinase, class I, catalyst activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
replaced_by: GO:0016303
replaced_by: GO:0035005
replaced_by: GO:0046934

[Term]
id: GO:0015073
name: phosphatidylinositol 3-kinase, class I, regulator activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137]
comment: This term was made obsolete because it refers to a class of gene products.
is_obsolete: true
replaced_by: GO:0046935

[Term]
id: GO:0015074
name: DNA integration
namespace: biological_process
def: "The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0015075
name: ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of an ion from one side of a membrane to the other." [GOC:def, GOC:df, GOC:mtg_transport, ISBN:0815340729]
subset: goslim_goa
subset: gosubset_prok
synonym: "ion transporter activity" EXACT []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0015076
name: heavy metal ion transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of heavy metal ions into, out of, within or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
is_obsolete: true
consider: GO:0046873

[Term]
id: GO:0015077
name: monovalent inorganic cation transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0022890 ! inorganic cation transmembrane transporter activity

[Term]
id: GO:0015078
name: hydrogen ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "proton transporter activity" EXACT []
xref: Reactome:1383 "hydrogen ion transmembrane transporter activity"
is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity

[Term]
id: GO:0015079
name: potassium ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0022817
def: "Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "potassium transporter activity" EXACT []
is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0015080
name: silver ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of silver (Ag) ions from one side of a membrane to the other." [GOC:ai]
synonym: "silver transporter activity" EXACT []
is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0015081
name: sodium ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0022816
def: "Catalysis of the transfer of sodium ions (Na+) from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "sodium transporter activity" EXACT []
is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0015082
name: di-, tri-valent inorganic cation transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of inorganic cations with a valency of two or three from one side of the membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0022890 ! inorganic cation transmembrane transporter activity

[Term]
id: GO:0015083
name: aluminum ion transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015084
def: "Catalysis of the transfer of aluminum (Al) ions from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "aluminium ion transporter activity" EXACT []
synonym: "aluminium resistance permease activity" EXACT []
synonym: "aluminum resistance permease activity" EXACT []
is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0015085
name: calcium ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other." [GOC:df]
subset: gosubset_prok
is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0015086
name: cadmium ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of cadmium (Cd) ions from one side of a membrane to the other." [GOC:df]
subset: gosubset_prok
synonym: "zinc, cadmium uptake permease activity" NARROW []
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW []
is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0015087
name: cobalt ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of cobalt (Co) ions from one side of a membrane to the other." [GOC:df]
subset: gosubset_prok
synonym: "cobalt, zinc uptake permease activity" NARROW []
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW []
is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0015088
name: copper uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Cu+(out) = Cu+(in)." [TC:9.A.12.-.-]
is_a: GO:0005375 ! copper ion transmembrane transporter activity

[Term]
id: GO:0015089
name: high affinity copper ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Cu2+(out) = Cu2+(in)." [TC:9.A.11.1.1]
synonym: "high affinity copper transporter activity" EXACT []
is_a: GO:0005375 ! copper ion transmembrane transporter activity

[Term]
id: GO:0015090
name: low affinity iron ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in)." [TC:9.A.9.1.1]
synonym: "low affinity iron transporter activity" EXACT []
is_a: GO:0005381 ! iron ion transmembrane transporter activity

[Term]
id: GO:0015091
name: ferric iron transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0005381 ! iron ion transmembrane transporter activity

[Term]
id: GO:0015092
name: high affinity ferric uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of Fe(III) from the outside of a cell to the inside of a cell across a membrane." [GOC:ai, TC:9.A.10.1.1]
is_a: GO:0015091 ! ferric iron transmembrane transporter activity

[Term]
id: GO:0015093
name: ferrous iron transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0005381 ! iron ion transmembrane transporter activity

[Term]
id: GO:0015094
name: lead ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of lead (Pb) ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW []
is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0015095
name: magnesium ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of magnesium (Mg) ions from one side of a membrane to the other." [GOC:df]
subset: gosubset_prok
is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0015096
name: manganese resistance permease activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport]
comment: This term was made obsolete because the term is undefined and we don't know the mechanism so we can't make a correct definition.
is_obsolete: true

[Term]
id: GO:0015097
name: mercury ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0015098
name: molybdate ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "molybdate transporter activity" EXACT []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015099
name: nickel ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of nickel (Ni) ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW []
is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0015100
name: vanadium ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of vanadium (V) ions from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0015101
name: organic cation transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0008324 ! cation transmembrane transporter activity

[Term]
id: GO:0015103
name: inorganic anion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008509 ! anion transmembrane transporter activity

[Term]
id: GO:0015104
name: antimonite transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of antimonite from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015105
name: arsenite transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of arsenite from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015106
name: bicarbonate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai]
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015107
name: chlorate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of chlorate from one side of a membrane to the other. Chlorates are inorganic salts of chloric acid that contain the ClO3- ion." [http://cancerweb.ncl.ac.uk/]
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015108
name: chloride transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of chloride ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015109
name: chromate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015110
name: cyanate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of cyanate, NCO-, the anion of cyanic acid, from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015111
name: iodide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of iodide ions from one side of a membrane to the other." [GOC:ai]
xref: Reactome:20767 "iodide transmembrane transporter activity"
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015112
name: nitrate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of nitrate ions (NO3-) from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "nitrite/nitrate porter activity" NARROW []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015113
name: nitrite transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of nitrite (NO2(-)) ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "nitrite/nitrate porter activity" NARROW []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015114
name: phosphate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015115
name: silicate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of silicates from one side of a membrane to the other. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai, http://cancerweb.ncl.ac.uk/]
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015116
name: sulfate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of sulfate ions (SO4 2-) from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "sulfate permease activity" RELATED []
synonym: "sulphate transporter activity" EXACT []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015117
name: thiosulfate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of thiosulfate ions (S2O3 2-) from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "thiosulfate permease activity" RELATED []
synonym: "thiosulphate transporter activity" EXACT []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015118
name: tellurite transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of tellurite from one side of a membrane to the other. Tellurite is a salt of tellurous acid or an oxide of tellurium which occurs sparingly in tufts of white or yellowish crystals." [GOC:ai, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0015119
name: hexose phosphate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of hexose phosphate from one side of the membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0015120
name: phosphoglycerate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of phosphoglycerates from one side of the membrane to the other. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005342 ! organic acid transmembrane transporter activity
is_a: GO:0008514 ! organic anion transmembrane transporter activity

[Term]
id: GO:0015121
name: phosphoenolpyruvate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of phosphoenolpyruvate from one side of a membrane to the other. Phosphoenolpyruvate is the phosphate ester formed from the hydroxy group of the enol tautomer of pyruvate. It is a key intermediate in glycolysis and gluconeogenesis, and in the biosynthesis of aromatic amino acids." [GOC:ai]
is_a: GO:0008514 ! organic anion transmembrane transporter activity

[Term]
id: GO:0015123
name: acetate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of acetate from one side of the membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:ai]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015124
name: allantoate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of allantoate from one side of the membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen." [GOC:ai, ISBN:0198547684]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015125
name: bile acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:ai]
xref: Reactome:20828 "bile acid transmembrane transporter activity"
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015126
name: canalicular bile acid transmembrane transporter activity
namespace: molecular_function
is_a: GO:0015125 ! bile acid transmembrane transporter activity

[Term]
id: GO:0015127
name: bilirubin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of bilirubin from one side of the membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile." [GOC:ai, ISBN:0198547684]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015128
name: gluconate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of gluconate from one side of the membrane to the other. Gluconate is the aldonic acid derived from glucose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0042879 ! aldonate transmembrane transporter activity

[Term]
id: GO:0015129
name: lactate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of lactate from one side of the membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" NARROW []
xref: Reactome:20840 "lactate transmembrane transporter activity"
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015130
name: mevalonate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of mevalonate from one side of the membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" NARROW []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015131
name: oxaloacetate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of the membrane to the other." [GOC:ai]
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015132
name: prostaglandin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of prostaglandins from one side of the membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [GOC:ai]
synonym: "prostaglandin/thromboxane transporter activity" BROAD []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015133
name: uronic acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of uronic acid from one side of the membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity

[Term]
id: GO:0015134
name: hexuronate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of hexuronates from one side of the membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015133 ! uronic acid transmembrane transporter activity

[Term]
id: GO:0015135
name: glucuronate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of glucuronate from one side of the membrane to the other. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai]
is_a: GO:0015134 ! hexuronate transmembrane transporter activity

[Term]
id: GO:0015136
name: sialic acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of sialic acid from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity

[Term]
id: GO:0015137
name: citrate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015142 ! tricarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015138
name: fumarate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of fumarate from one side of the membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [GOC:ai]
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW []
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015139
name: alpha-ketoglutarate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of alpha-ketoglutarate from one side of the membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle." [GOC:ai, ISBN:0198547684]
subset: gosubset_prok
synonym: "2-oxoglutarate transporter activity" EXACT []
xref: Reactome:20894 "alpha-ketoglutarate transmembrane transporter activity"
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015140
name: malate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of malate from one side of the membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [GOC:ai]
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW []
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity

[Term]
id: GO:0015141
name: succinate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of the membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW []
is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity

[Term]
id: GO:0015142
name: tricarboxylic acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of tricarboxylic acids from one side of the membrane to the other. Tricarboxylic acid are organic acids with three COOH groups." [GOC:ai]
subset: gosubset_prok
synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW []
xref: Reactome:14023 "tricarboxylic acid transmembrane transporter activity"
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0015143
name: urate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of urate from one side of the membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals." [GOC:ai]
synonym: "uric acid transmembrane transporter activity" EXACT []
is_a: GO:0005342 ! organic acid transmembrane transporter activity

[Term]
id: GO:0015144
name: carbohydrate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of carbohydrate from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "sugar transporter" NARROW []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0015145
name: monosaccharide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of monosaccharide from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0051119 ! sugar transmembrane transporter activity

[Term]
id: GO:0015146
name: pentose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a pentose sugar, a monosaccharide with 5 carbon atoms, from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity

[Term]
id: GO:0015147
name: L-arabinose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-arabinose from one side of the membrane to the other. Arabinose occurs free, for example in the heartwood of many conifers and in the combined states, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides, etc." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW []
is_a: GO:0042900 ! arabinose transmembrane transporter activity

[Term]
id: GO:0015148
name: D-xylose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of D-xylose from one side of the membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015146 ! pentose transmembrane transporter activity

[Term]
id: GO:0015149
name: hexose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
xref: Reactome:7702 "hexose transmembrane transporter activity"
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity

[Term]
id: GO:0015150
name: fucose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of fucose from one side of the membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0015151
name: alpha-glucoside transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of alpha-glucosides from one side of the membrane to the other. Alpha-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
is_a: GO:0042947 ! glucoside transmembrane transporter activity

[Term]
id: GO:0015152
name: glucose-6-phosphate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of glucose-6-phosphate from one side of the membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
xref: Reactome:20967 "glucose-6-phosphate transmembrane transporter activity"
is_a: GO:0015119 ! hexose phosphate transmembrane transporter activity

[Term]
id: GO:0015153
name: rhamnose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of rhamnose from one side of the membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0015154
name: disaccharide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of disaccharide from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0051119 ! sugar transmembrane transporter activity

[Term]
id: GO:0015155
name: lactose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0019189
def: "Catalysis of the transfer of lactose from one side of the membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
synonym: "lactose permease activity" EXACT []
synonym: "lactose/glucose efflux transporter activity" NARROW []
is_a: GO:0015154 ! disaccharide transmembrane transporter activity

[Term]
id: GO:0015156
name: melibiose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of melibiose from one side of the membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015154 ! disaccharide transmembrane transporter activity

[Term]
id: GO:0015157
name: oligosaccharide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of oligosaccharide from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "endosomal oligosaccharide transporter" NARROW []
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity

[Term]
id: GO:0015158
name: raffinose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of raffinose from one side of the membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
synonym: "raffinose permease" RELATED []
is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity

[Term]
id: GO:0015159
name: polysaccharide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of polysaccharides from one side of the membrane to the other. A polysaccharide is a polymer of more than about 10 monosaccharide residues joined by glycosidic linkages." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity

[Term]
id: GO:0015160
name: beta-glucan transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of beta-glucans from one side of the membrane to the other. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015159 ! polysaccharide transmembrane transporter activity

[Term]
id: GO:0015161
name: capsular polysaccharide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of capsular-polysaccharides from one side of the membrane to the other. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "capsule polysaccharide transporter activity" EXACT []
is_a: GO:0015159 ! polysaccharide transmembrane transporter activity

[Term]
id: GO:0015162
name: teichoic acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of teichoic acid from one side of the membrane to the other. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015159 ! polysaccharide transmembrane transporter activity

[Term]
id: GO:0015163
name: hexuronide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a hexuronide from one side of the membrane to the other. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity

[Term]
id: GO:0015164
name: glucuronoside transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucuronosides from one side of the membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "glucuronide transporter activity" EXACT []
is_a: GO:0015163 ! hexuronide transmembrane transporter activity

[Term]
id: GO:0015165
name: pyrimidine nucleotide sugar transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a pyrimidine nucleotide-sugar from one side of the membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005338 ! nucleotide-sugar transmembrane transporter activity

[Term]
id: GO:0015166
name: polyol transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sugar/polyol channel activity" NARROW []
is_a: GO:0015665 ! alcohol transmembrane transporter activity

[Term]
id: GO:0015167
name: arabitol transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of an arabitol from one side of the membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "arabinitol transporter activity" EXACT []
is_a: GO:0015166 ! polyol transmembrane transporter activity

[Term]
id: GO:0015168
name: glycerol transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of glycerol from one side of the membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015166 ! polyol transmembrane transporter activity

[Term]
id: GO:0015169
name: glycerol-3-phosphate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of glycerol-3-phosphate from one side of the membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015168 ! glycerol transmembrane transporter activity

[Term]
id: GO:0015170
name: propanediol transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of propanediol from one side of the membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [GOC:ai]
is_a: GO:0015166 ! polyol transmembrane transporter activity

[Term]
id: GO:0015171
name: amino acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015359
def: "Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "amino acid permease activity" EXACT []
synonym: "amino acid transporter activity" BROAD []
synonym: "amino acid/choline transmembrane transporter activity" NARROW []
synonym: "general amino acid permease activity" RELATED []
synonym: "hydroxy/aromatic amino acid permease activity" NARROW []
xref: Reactome:13305 "amino acid transmembrane transporter activity"
is_a: GO:0005275 ! amine transmembrane transporter activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0015172
name: acidic amino acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "acidic amino acid transporter activity" BROAD []
xref: Reactome:13353 "acidic amino acid transmembrane transporter activity"
is_a: GO:0015171 ! amino acid transmembrane transporter activity

[Term]
id: GO:0015173
name: aromatic amino acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "aromatic amino acid transporter activity" BROAD []
synonym: "hydroxy/aromatic amino acid permease activity" NARROW []
synonym: "valine/tyrosine/tryptophan permease activity" RELATED []
is_a: GO:0015171 ! amino acid transmembrane transporter activity

[Term]
id: GO:0015174
name: basic amino acid transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005286
def: "Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "basic amino acid permease activity" EXACT []
synonym: "basic amino acid transporter activity" BROAD []
is_a: GO:0015171 ! amino acid transmembrane transporter activity

[Term]
id: GO:0015175
name: neutral amino acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "neutral amino acid transporter activity" BROAD []
is_a: GO:0015171 ! amino acid transmembrane transporter activity

[Term]
id: GO:0015176
name: holin
namespace: molecular_function
def: "OBSOLETE. Primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall of bacteria, where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded, these enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some catalyze export of nucleases." [TC:1.A.38.-.-]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
consider: GO:0008565
consider: GO:0019835

[Term]
id: GO:0015179
name: L-amino acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-amino acid transporter activity" BROAD []
xref: Reactome:13355 "L-amino acid transmembrane transporter activity"
is_a: GO:0015171 ! amino acid transmembrane transporter activity

[Term]
id: GO:0015180
name: L-alanine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
synonym: "L-alanine transporter activity" BROAD []
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0022858 ! alanine transmembrane transporter activity

[Term]
id: GO:0015181
name: arginine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005288
def: "Catalysis of the stereospecific transfer of arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
synonym: "arginine permease activity" EXACT []
synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW []
synonym: "L-arginine transporter activity" NARROW []
is_a: GO:0015174 ! basic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015182
name: L-asparagine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
synonym: "asparagine/glutamine permease activity" NARROW []
synonym: "L-asparagine transporter activity" BROAD []
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015183
name: L-aspartate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
synonym: "glutamate/aspartate porter activity" NARROW []
synonym: "glutamate/aspartate:sodium symporter activity" NARROW []
synonym: "L-aspartate transporter activity" BROAD []
is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015184
name: L-cystine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-cystine from one side of a membrane to the other." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
synonym: "cystine/diaminopimelate porter activity" NARROW []
synonym: "L-cystine transporter activity" BROAD []
is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015185
name: L-gamma-aminobutyric acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-gamma-aminobutyric acid from one side of a membrane to the other. L-gamma-aminobutyric acid is 4-aminobutyrate (GABA)." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
synonym: "4-aminobutanoate transporter activity" EXACT []
synonym: "4-aminobutyrate transporter activity" EXACT []
synonym: "betaine/GABA:sodium symporter activity" NARROW []
synonym: "GABA transporter activity" EXACT []
synonym: "L-gamma-aminobutyrate transporter activity" EXACT []
synonym: "L-gamma-aminobutyric acid transporter activity" BROAD []
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015186
name: L-glutamine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "asparagine/glutamine permease activity" NARROW []
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015187
name: glycine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "glycine betaine/proline porter activity" NARROW []
synonym: "glycine transporter activity" BROAD []
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity

[Term]
id: GO:0015188
name: L-isoleucine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "isoleucine/valine:sodium symporter activity" NARROW []
synonym: "L-isoleucine transporter activity" BROAD []
synonym: "leucine/isoleucine/valine porter activity" NARROW []
synonym: "leucine/valine/isoleucine permease activity" NARROW []
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015189
name: L-lysine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005293
def: "Catalysis of the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW []
synonym: "L-lysine permease" RELATED []
synonym: "lysine permease activity" RELATED []
is_a: GO:0015174 ! basic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015190
name: L-leucine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "L-leucine transporter activity" BROAD []
synonym: "leucine/isoleucine/valine porter activity" NARROW []
synonym: "leucine/valine/isoleucine permease activity" NARROW []
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015191
name: L-methionine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-methionine transporter activity" BROAD []
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0043865 ! methionine transmembrane transporter activity

[Term]
id: GO:0015192
name: L-phenylalanine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-phenylalanine permease activity" EXACT []
synonym: "L-phenylalanine transporter activity" BROAD []
is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015193
name: L-proline transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005296
def: "Catalysis of the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "glycine betaine/proline porter activity" NARROW []
synonym: "L-proline permease activity" RELATED []
synonym: "L-proline transporter activity" BROAD []
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015194
name: L-serine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015511
def: "Catalysis of the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-serine permease activity" RELATED []
synonym: "L-serine transporter activity" BROAD []
synonym: "serine transporter activity" BROAD []
synonym: "threonine/serine:sodium symporter activity" NARROW []
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0022889 ! serine transmembrane transporter activity

[Term]
id: GO:0015195
name: L-threonine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015512
def: "Catalysis of the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-threonine permease activity" RELATED []
synonym: "L-threonine transporter activity" BROAD []
synonym: "threonine/serine:sodium symporter activity" NARROW []
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015196
name: L-tryptophan transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005299
def: "Catalysis of the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-tryptophan permease activity" EXACT []
synonym: "L-tryptophan transporter activity" BROAD []
synonym: "valine/tyrosine/tryptophan permease activity" NARROW []
is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015197
name: peptide transporter activity
namespace: molecular_function
alt_id: GO:0015637
def: "Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells." [GOC:ai]
subset: gosubset_prok
synonym: "peptide uptake permease activity" RELATED []
is_a: GO:0022892 ! substrate-specific transporter activity

[Term]
id: GO:0015198
name: oligopeptide transporter activity
namespace: molecular_function
def: "Enables the directed movement of oligopeptides into, out of, within or between cells. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015197 ! peptide transporter activity

[Term]
id: GO:0015199
name: betaine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of betaine, the N-trimethyl derivative of an amino acid, from one side of the membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "betaine/GABA:sodium symporter activity" NARROW []
synonym: "glycine betaine/proline porter activity" NARROW []
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
is_a: GO:0005275 ! amine transmembrane transporter activity

[Term]
id: GO:0015200
name: methylammonium transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of methylammonium, CH3NH2, into, out of, within or between cells." [GOC:ai]
is_a: GO:0005275 ! amine transmembrane transporter activity

[Term]
id: GO:0015203
name: polyamine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of polyamines, organic compounds containing two or more amino groups, from one side of the membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "amine/amide/polyamine channel activity" NARROW []
is_a: GO:0005275 ! amine transmembrane transporter activity

[Term]
id: GO:0015204
name: urea transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015287
def: "Enables the directed movement of urea cross a membrane into, out of, within or between cells. Urea is the water soluble compound H2N-CO-NH2, produced in the liver via the ornithine-urea cycle. It is the main nitrogen-containing (urinary) excretion product in ureotelic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "urea transporter activity" BROAD []
is_a: GO:0042887 ! amide transmembrane transporter activity

[Term]
id: GO:0015205
name: nucleobase transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015392
def: "Catalysis of the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015932 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity

[Term]
id: GO:0015207
name: adenine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of adenine, 6-aminopurine, from one side of a membrane to the other." [GOC:go_curators]
xref: Reactome:21842 "adenine transmembrane transporter activity"
is_a: GO:0005345 ! purine transmembrane transporter activity

[Term]
id: GO:0015208
name: guanine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other." [GOC:go_curators]
is_a: GO:0005345 ! purine transmembrane transporter activity

[Term]
id: GO:0015209
name: cytosine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0005350 ! pyrimidine transmembrane transporter activity

[Term]
id: GO:0015210
name: uracil transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other." [GOC:go_curators]
subset: gosubset_prok
synonym: "uracil/uridine permease activity" RELATED []
is_a: GO:0005350 ! pyrimidine transmembrane transporter activity

[Term]
id: GO:0015211
name: purine nucleoside transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005337 ! nucleoside transmembrane transporter activity

[Term]
id: GO:0015212
name: cytidine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of cytidine, cytosine riboside, from one side of a membrane to the other." [GOC:go_curators]
is_a: GO:0015214 ! pyrimidine nucleoside transmembrane transporter activity

[Term]
id: GO:0015213
name: uridine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of uridine, uracil riboside, from one side of a membrane to the other." [GOC:go_curators]
synonym: "uracil/uridine permease activity" NARROW []
is_a: GO:0015214 ! pyrimidine nucleoside transmembrane transporter activity

[Term]
id: GO:0015214
name: pyrimidine nucleoside transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other." [GOC:ai]
is_a: GO:0005337 ! nucleoside transmembrane transporter activity

[Term]
id: GO:0015215
name: nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015932 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity

[Term]
id: GO:0015216
name: purine nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015215 ! nucleotide transmembrane transporter activity

[Term]
id: GO:0015217
name: ADP transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity

[Term]
id: GO:0015218
name: pyrimidine nucleotide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015215 ! nucleotide transmembrane transporter activity

[Term]
id: GO:0015219
name: protein-DNA complex transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of protein-DNA complexes from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "DNA-protein complex transmembrane transporter activity" EXACT [GOC:mah]
is_a: GO:0015932 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity

[Term]
id: GO:0015220
name: choline transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005306
def: "Catalysis of the transfer of choline from one side of the membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai]
subset: gosubset_prok
synonym: "amino acid/choline transmembrane transporter activity" NARROW []
synonym: "choline permease activity" EXACT []
xref: Reactome:13999 "choline transmembrane transporter activity"
is_a: GO:0005275 ! amine transmembrane transporter activity

[Term]
id: GO:0015221
name: lipopolysaccharide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of lipopolysaccharides from one side of the membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "LPS transmembrane transporter activity" EXACT []
is_a: GO:0015159 ! polysaccharide transmembrane transporter activity

[Term]
id: GO:0015222
name: serotonin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of serotonin from one side of the membrane to the other. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
is_a: GO:0008504 ! monoamine transmembrane transporter activity

[Term]
id: GO:0015223
name: vitamin or cofactor transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed transport of vitamins or cofactors into, out of, within or between cells." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "vitamin/cofactor transporter activity" EXACT []
is_obsolete: true
consider: GO:0051183
consider: GO:0051184

[Term]
id: GO:0015224
name: biopterin transporter activity
namespace: molecular_function
def: "Enables the directed movement of biopterin into, out of, within or between cells. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0051184 ! cofactor transporter activity

[Term]
id: GO:0015225
name: biotin transporter activity
namespace: molecular_function
def: "Enables the directed movement of biotin into, out of, within or between cells. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai]
synonym: "vitamin B7 transporter activity" EXACT []
synonym: "vitamin H transporter activity" EXACT []
is_a: GO:0051183 ! vitamin transporter activity
is_a: GO:0051184 ! cofactor transporter activity

[Term]
id: GO:0015226
name: carnitine transporter activity
namespace: molecular_function
def: "Enables the directed movement of carnitine into, out of, within or between cells. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin Bt transporter activity" EXACT []
is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity
is_a: GO:0051183 ! vitamin transporter activity
is_a: GO:0051184 ! cofactor transporter activity

[Term]
id: GO:0015227
name: acyl carnitine transporter activity
namespace: molecular_function
def: "Enables the directed movement of acyl carnitine into, out of, within or between cells. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai, http://cancerweb.ncl.ac.uk/]
synonym: "acylcarnitine transporter activity" EXACT []
xref: Reactome:21898 "acyl carnitine transporter activity"
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0015228
name: coenzyme A transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of coenzyme A across a membrane into, out of, within or between cells. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai]
synonym: "coenzyme A transporter activity" BROAD []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:0051185 ! coenzyme transporter activity

[Term]
id: GO:0015229
name: L-ascorbic acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of L-ascorbate into, out of, within or between cells. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [ChEBI:38290, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "L-ascorbate transporter activity" EXACT []
synonym: "vitamin C transporter activity" EXACT []
xref: Reactome:21900 "L-ascorbic acid transporter activity"
is_a: GO:0051183 ! vitamin transporter activity

[Term]
id: GO:0015230
name: FAD transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of flavin-adenine dinucleotide (FAD) across a membrane into, out of, within or between cells. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "FAD transporter activity" BROAD []
synonym: "flavin adenine dinucleotide transmembrane transporter activity" EXACT []
synonym: "flavin-adenine dinucleotide transmembrane transporter activity" EXACT []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:0051184 ! cofactor transporter activity

[Term]
id: GO:0015231
name: 5-formyltetrahydrofolate transporter activity
namespace: molecular_function
def: "Enables the directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells." [GOC:ai]
is_a: GO:0008517 ! folic acid transporter activity

[Term]
id: GO:0015232
name: heme transporter activity
namespace: molecular_function
def: "Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells." [GOC:ai]
subset: gosubset_prok
synonym: "haem transporter activity" EXACT []
is_a: GO:0051184 ! cofactor transporter activity

[Term]
id: GO:0015233
name: pantothenate transporter activity
namespace: molecular_function
def: "Enables the directed movement of pantothenate into, out of, within or between cells. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "vitamin B5 transporter activity" EXACT []
is_a: GO:0051183 ! vitamin transporter activity
is_a: GO:0051184 ! cofactor transporter activity

[Term]
id: GO:0015234
name: thiamin transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015402
def: "Catalysis of the transfer of thiamin from one side of the membrane to the other. Thiamin is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "thiamin permease activity" EXACT []
synonym: "thiamine permease activity" EXACT []
synonym: "thiamine transmembrane transporter activity" EXACT []
synonym: "vitamin B1 transporter activity" EXACT []
xref: Reactome:21936 "thiamin transmembrane transporter activity"
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:0051183 ! vitamin transporter activity

[Term]
id: GO:0015235
name: cobalamin transporter activity
namespace: molecular_function
def: "Enables the directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin B12 transporter activity" EXACT []
is_a: GO:0051183 ! vitamin transporter activity

[Term]
id: GO:0015238
name: drug transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015239
name: multidrug transporter activity
namespace: molecular_function
def: "Enables the directed movement of drugs across a membrane into, out of, within or between cells." [GOC:ai, GOC:mah]
subset: gosubset_prok
is_a: GO:0015238 ! drug transmembrane transporter activity

[Term]
id: GO:0015240
name: amiloride transporter activity
namespace: molecular_function
def: "Enables the directed movement of amiloride of amiloride into, out of, within or between cells. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0015238 ! drug transmembrane transporter activity

[Term]
id: GO:0015241
name: aminotriazole transporter activity
namespace: molecular_function
def: "Enables the directed movement of aminotriazole into, out of, within or between cells. Aminotriazole is an effective weed killer that also possesses some antithyroid activity." [http://cancerweb.ncl.ac.uk/]
is_a: GO:0045118 ! azole transporter activity

[Term]
id: GO:0015242
name: benomyl transporter activity
namespace: molecular_function
def: "Enables the directed movement of benomyl into, out of, within or between cells. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit." [http://cancerweb.ncl.ac.uk/]
is_a: GO:0015238 ! drug transmembrane transporter activity
is_a: GO:0042910 ! xenobiotic transporter activity

[Term]
id: GO:0015243
name: cycloheximide transporter activity
namespace: molecular_function
def: "Enables the directed movement of cycloheximide into, out of, within or between cells. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0042895 ! antibiotic transporter activity

[Term]
id: GO:0015244
name: fluconazole transporter activity
namespace: molecular_function
def: "Enables the directed movement of fluconazole into, out of, within or between cells. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [http://cancerweb.ncl.ac.uk/]
is_a: GO:0045118 ! azole transporter activity

[Term]
id: GO:0015245
name: fatty acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of fatty acids into, out of, within or between cells. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0005319 ! lipid transporter activity

[Term]
id: GO:0015246
name: fatty acyl transporter activity
namespace: molecular_function
def: "Enables the directed movement of a fatty acyl group into, out of, within or between cells. A fatty acyl group is any acyl group derived from a fatty acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "peroxisomal fatty acyl transporter" NARROW []
is_a: GO:0005319 ! lipid transporter activity

[Term]
id: GO:0015247
name: aminophospholipid transporter activity
namespace: molecular_function
def: "Enables the directed movement of aminophospholipids into, out of, within or between cells. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005548 ! phospholipid transporter activity

[Term]
id: GO:0015248
name: sterol transporter activity
namespace: molecular_function
def: "Enables the directed movement of sterols into, out of, within or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai]
xref: Reactome:21984 "sterol transporter activity"
is_a: GO:0005319 ! lipid transporter activity

[Term]
id: GO:0015250
name: water channel activity
namespace: molecular_function
def: "Transport systems of this type catalyze facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "aquaporin" NARROW []
is_a: GO:0005372 ! water transmembrane transporter activity
is_a: GO:0022838 ! substrate-specific channel activity

[Term]
id: GO:0015251
name: ammonium channel activity
namespace: molecular_function
def: "Catalysis of facilitated diffusion of ammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005261 ! cation channel activity
is_a: GO:0008519 ! ammonium transmembrane transporter activity

[Term]
id: GO:0015252
name: hydrogen ion channel activity
namespace: molecular_function
def: "Catalysis of facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005261 ! cation channel activity

[Term]
id: GO:0015253
name: sugar/polyol channel activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents two molecular functions.
is_obsolete: true
consider: GO:0015166
consider: GO:0051119

[Term]
id: GO:0015254
name: glycerol channel activity
namespace: molecular_function
def: "Catalysis of facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015168 ! glycerol transmembrane transporter activity

[Term]
id: GO:0015255
name: propanediol channel activity
namespace: molecular_function
def: "Catalysis of facilitated diffusion of propanediol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport]
is_a: GO:0015170 ! propanediol transmembrane transporter activity

[Term]
id: GO:0015256
name: monocarboxylate channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
is_obsolete: true

[Term]
id: GO:0015257
name: organic anion channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
is_obsolete: true

[Term]
id: GO:0015258
name: gluconate channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
is_obsolete: true

[Term]
id: GO:0015259
name: glutamate channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
is_obsolete: true

[Term]
id: GO:0015260
name: isethionate channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
is_obsolete: true

[Term]
id: GO:0015261
name: lactate channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
is_obsolete: true

[Term]
id: GO:0015262
name: taurine channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel.
is_obsolete: true

[Term]
id: GO:0015263
name: amine/amide/polyamine channel activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents three molecular functions.
is_obsolete: true
consider: GO:0005275
consider: GO:0015203
consider: GO:0042887

[Term]
id: GO:0015264
name: methylammonium channel activity
namespace: molecular_function
def: "Catalysis of facilitated diffusion of methylammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Methylammonium is CH3NH2." [GOC:mtg_transport]
is_a: GO:0015200 ! methylammonium transmembrane transporter activity

[Term]
id: GO:0015265
name: urea channel activity
namespace: molecular_function
def: "Catalysis of facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport]
is_a: GO:0015204 ! urea transmembrane transporter activity
is_a: GO:0022838 ! substrate-specific channel activity

[Term]
id: GO:0015266
name: protein channel activity
namespace: molecular_function
def: "Catalysis of energy-independent facilitated diffusion, mediated by passage of proteins through a transmembrane aqueous pore or channel." [GOC:rb]
is_a: GO:0008320 ! protein transmembrane transporter activity
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0015267
name: channel activity
namespace: molecular_function
alt_id: GO:0015249
alt_id: GO:0015268
def: "Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729, TC:1.-.-.-.-]
subset: goslim_goa
subset: gosubset_prok
synonym: "alpha-type channel activity" RELATED []
synonym: "channel-forming toxin activity" RELATED []
synonym: "channel/pore class transporter activity" EXACT []
synonym: "nonselective channel activity" EXACT []
synonym: "pore activity" BROAD []
synonym: "pore class transporter activity" RELATED []
xref: TC:1
is_a: GO:0022803 ! passive transmembrane transporter activity

[Term]
id: GO:0015269
name: calcium-activated potassium channel activity
namespace: molecular_function
def: "Catalysis of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]
subset: gosubset_prok
is_a: GO:0005227 ! calcium activated cation channel activity
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0022839 ! ion gated channel activity

[Term]
id: GO:0015270
name: dihydropyridine-sensitive calcium channel activity
namespace: molecular_function
is_a: GO:0005245 ! voltage-gated calcium channel activity

[Term]
id: GO:0015271
name: outward rectifier potassium channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force." [GOC:mah]
is_a: GO:0005249 ! voltage-gated potassium channel activity

[Term]
id: GO:0015272
name: ATP-activated inward rectifier potassium channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force." [GOC:cb, GOC:mah]
is_a: GO:0005242 ! inward rectifier potassium channel activity

[Term]
id: GO:0015274
name: organellar voltage-gated chloride channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "organellar voltage gated chloride channel activity" EXACT []
synonym: "organellar voltage-dependent chloride channel activity" EXACT []
is_a: GO:0005247 ! voltage-gated chloride channel activity

[Term]
id: GO:0015275
name: stretch-activated, cation-selective, calcium channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching." [GOC:mtg_transport]
is_a: GO:0005262 ! calcium channel activity
is_a: GO:0008381 ! mechanically-gated ion channel activity

[Term]
id: GO:0015276
name: ligand-gated ion channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "ionotropic neurotransmitter receptor" NARROW []
is_a: GO:0005216 ! ion channel activity
is_a: GO:0022834 ! ligand-gated channel activity

[Term]
id: GO:0015277
name: kainate selective glutamate receptor activity
namespace: molecular_function
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'.
is_a: GO:0004970 ! ionotropic glutamate receptor activity

[Term]
id: GO:0015278
name: calcium-release channel activity
namespace: molecular_function
is_a: GO:0005262 ! calcium channel activity
is_a: GO:0015276 ! ligand-gated ion channel activity

[Term]
id: GO:0015279
name: store-operated calcium channel activity
namespace: molecular_function
def: "A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores." [GOC:dph, GOC:tb, PMID:15788710]
is_a: GO:0005262 ! calcium channel activity
is_a: GO:0015276 ! ligand-gated ion channel activity

[Term]
id: GO:0015280
name: amiloride-sensitive sodium channel activity
namespace: molecular_function
synonym: "epithelial sodium channel" EXACT []
is_a: GO:0005272 ! sodium channel activity
is_a: GO:0015276 ! ligand-gated ion channel activity

[Term]
id: GO:0015282
name: NADPH oxidase-associated cytochrome b558 hydrogen channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because it describes a gene product rather than a function.
synonym: "NADPH oxidase-associated cytochrome b558 proton channel" EXACT []
is_obsolete: true

[Term]
id: GO:0015283
name: apoptogenic cytochrome c release channel activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because it represents a gene product.
synonym: "Bcl-2" NARROW []
is_obsolete: true

[Term]
id: GO:0015284
name: fructose uniporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in)." [TC:2.A.1.1.13]
is_a: GO:0005353 ! fructose transmembrane transporter activity
is_a: GO:0008516 ! hexose uniporter activity

[Term]
id: GO:0015288
name: porin activity
namespace: molecular_function
def: "Catalysis of the transfer of substances, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-]
subset: gosubset_prok
synonym: "outer membrane exporter porin" NARROW []
synonym: "porin" EXACT []
xref: Wikipedia:Porin_(protein)
is_a: GO:0022829 ! wide pore channel activity

[Term]
id: GO:0015289
name: pore-forming toxin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transport of electrolytes and other small molecules across a cell membrane. They are synthesized by one cell and secreted for insertion into the membrane of another cell where they form transmembrane pores. They may exert their toxic effects by allowing the free flow of electrolytes and other small molecules across the membrane, or they may allow entry into the target cell cytoplasm of a toxin protein that ultimately kills the cell." [PMID:10839820]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
consider: GO:0005198
consider: GO:0009405
consider: GO:0046930
consider: GO:0046931
consider: GO:0050827

[Term]
id: GO:0015291
name: secondary active transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015290
def: "Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729, PMID:10839820]
subset: gosubset_prok
synonym: "active transporter" BROAD []
synonym: "coupled carrier" EXACT []
synonym: "electrochemical potential-driven transporter activity" EXACT []
synonym: "galactose/glucose (methylgalactoside) porter activity" NARROW []
synonym: "heavy metal ion porter activity" NARROW []
synonym: "nitrite/nitrate porter activity" NARROW []
synonym: "porter activity" EXACT []
synonym: "porters" EXACT []
synonym: "secondary carrier-type facilitators" EXACT []
xref: Reactome:3124 "secondary active transmembrane transporter activity"
xref: TC:2.A
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0015292
name: uniporter activity
namespace: molecular_function
def: "Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
subset: gosubset_prok
synonym: "facilitated diffusion carrier" EXACT []
synonym: "single-species transporter activity" EXACT []
synonym: "uniport" RELATED []
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015293
name: symporter activity
namespace: molecular_function
def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
subset: gosubset_prok
synonym: "cotransporter activity" BROAD []
synonym: "porter activity" BROAD []
synonym: "symport" RELATED []
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015294
name: solute:cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015293 ! symporter activity

[Term]
id: GO:0015295
name: solute:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in)." [GOC:ai]
subset: gosubset_prok
synonym: "heavy metal ion:hydrogen symporter activity" NARROW []
synonym: "high affinity metal ion uptake transporter activity" NARROW []
synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW []
synonym: "low affinity metal ion uptake transporter activity" NARROW []
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
synonym: "solute:proton symporter activity" EXACT []
is_a: GO:0015294 ! solute:cation symporter activity

[Term]
id: GO:0015296
name: anion:cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in)." [TC:2.A.1.14.-]
subset: gosubset_prok
is_a: GO:0008509 ! anion transmembrane transporter activity
is_a: GO:0015294 ! solute:cation symporter activity

[Term]
id: GO:0015297
name: antiporter activity
namespace: molecular_function
def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]
subset: gosubset_prok
synonym: "antiport" RELATED []
synonym: "countertransporter activity" EXACT []
synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW []
synonym: "exchange transporter activity" EXACT []
synonym: "exchanger" BROAD []
synonym: "porter" BROAD []
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015298
name: solute:cation antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015300 ! solute:solute antiporter activity

[Term]
id: GO:0015299
name: solute:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai]
subset: gosubset_prok
synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW []
synonym: "solute:proton antiporter activity" EXACT []
is_a: GO:0015298 ! solute:cation antiporter activity

[Term]
id: GO:0015300
name: solute:solute antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:ai]
subset: gosubset_prok
synonym: "solute:solute exchange" RELATED []
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0015301
name: anion:anion antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out)." [GOC:ai, GOC:mtg_transport]
subset: gosubset_prok
is_a: GO:0008509 ! anion transmembrane transporter activity
is_a: GO:0015300 ! solute:solute antiporter activity

[Term]
id: GO:0015303
name: galactose, glucose uniporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: galactose or glucose(out) = galactose or glucose(in)." [TC:2.A.1.1.6]
comment: This term was made obsolete because it represents two molecular functions.
is_obsolete: true
consider: GO:0015304
consider: GO:0050782

[Term]
id: GO:0015304
name: glucose uniporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in)." [TC:2.A.1.1.12, TC:2.A.1.1.4, TC:2.A.1.1.6]
synonym: "galactose, glucose uniporter activity" NARROW []
is_a: GO:0005355 ! glucose transmembrane transporter activity
is_a: GO:0008516 ! hexose uniporter activity

[Term]
id: GO:0015305
name: lactose, galactose:hydrogen symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (lactose or galactose)(out) + H+(out) = (lactose or galactose)(in) + H+(in)." [TC:2.A.1.1.9]
comment: This term was made obsolete because it represents two molecular functions.
synonym: "lactose,galactose:proton symporter activity" EXACT []
is_obsolete: true
consider: GO:0015517
consider: GO:0015528

[Term]
id: GO:0015306
name: sialate:cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in)." [TC:2.A.1.14.10]
synonym: "cation/sialate symporter activity" EXACT []
synonym: "cation:sialate symporter activity" EXACT []
synonym: "sialate transporter activity" BROAD []
synonym: "sialate/cation symporter activity" EXACT []
is_a: GO:0005351 ! sugar:hydrogen symporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015307
name: drug:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + drug(in) = H+(in) + drug(out)." [TC:2.A.1.2.-, TC:2.A.1.3.-]
subset: gosubset_prok
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW []
synonym: "drug:proton antiporter activity" EXACT []
is_a: GO:0015238 ! drug transmembrane transporter activity
is_a: GO:0015299 ! solute:hydrogen antiporter activity

[Term]
id: GO:0015308
name: amiloride:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + amiloride(in) = H+(in) + amiloride(out)." [TC:2.A.1.2.1]
synonym: "amiloride:proton antiporter activity" EXACT []
is_a: GO:0015240 ! amiloride transporter activity
is_a: GO:0015307 ! drug:hydrogen antiporter activity

[Term]
id: GO:0015309
name: cycloheximide:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out)." [TC:2.A.1.2.2]
synonym: "cycloheximide:proton antiporter activity" EXACT []
is_a: GO:0015307 ! drug:hydrogen antiporter activity

[Term]
id: GO:0015310
name: benomyl:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out)." [TC:2.A.1.2.6]
synonym: "benomyl:proton antiporter activity" EXACT []
is_a: GO:0015307 ! drug:hydrogen antiporter activity

[Term]
id: GO:0015311
name: monoamine:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out)." [TC:2.A.1.2.11, TC:2.A.1.2.12]
synonym: "monoamine:proton antiporter activity" EXACT []
is_a: GO:0008504 ! monoamine transmembrane transporter activity
is_a: GO:0015299 ! solute:hydrogen antiporter activity

[Term]
id: GO:0015312
name: polyamine:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out)." [TC:2.A.1.2.16]
synonym: "polyamine:proton antiporter activity" EXACT []
is_a: GO:0015203 ! polyamine transmembrane transporter activity
is_a: GO:0015299 ! solute:hydrogen antiporter activity

[Term]
id: GO:0015313
name: fluconazole:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out)." [TC:2.A.1.2.17]
synonym: "fluconazole:proton antiporter activity" EXACT []
is_a: GO:0015244 ! fluconazole transporter activity
is_a: GO:0045119 ! azole:hydrogen antiporter activity

[Term]
id: GO:0015314
name: aminotriazole:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out)." [TC:2.A.1.3.1]
synonym: "aminotriazole:proton antiporter activity" EXACT []
is_a: GO:0015241 ! aminotriazole transporter activity
is_a: GO:0045119 ! azole:hydrogen antiporter activity

[Term]
id: GO:0015315
name: organophosphate:inorganic phosphate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + inorganic phosphate(in) = organophosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.-]
is_a: GO:0015114 ! phosphate transmembrane transporter activity
is_a: GO:0015300 ! solute:solute antiporter activity

[Term]
id: GO:0015316
name: nitrite/nitrate porter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0015112
consider: GO:0015113
consider: GO:0015291

[Term]
id: GO:0015317
name: phosphate:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in)." [TC:2.A.1.9.-]
synonym: "phosphate:proton symporter activity" EXACT []
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015114 ! phosphate transmembrane transporter activity
is_a: GO:0015295 ! solute:hydrogen symporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015318
name: inorganic solute uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of an inorganic solute from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "inorganic uptake permease activity" EXACT []
is_a: GO:0015114 ! phosphate transmembrane transporter activity
is_a: GO:0015563 ! uptake transmembrane transporter activity

[Term]
id: GO:0015319
name: sodium:inorganic phosphate symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in)." [TC:2.A.1.14.6]
is_a: GO:0005436 ! sodium:phosphate symporter activity

[Term]
id: GO:0015320
name: phosphate carrier activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate (cyt) + H+ (cyt) = phosphate (mitochondrion) + H+ (mitochondrion)." [GOC:curators, TC:2.A.29.4.1]
is_a: GO:0015114 ! phosphate transmembrane transporter activity

[Term]
id: GO:0015321
name: sodium-dependent phosphate transmembrane transporter activity
namespace: molecular_function
subset: gosubset_prok
is_a: GO:0015114 ! phosphate transmembrane transporter activity

[Term]
id: GO:0015322
name: secondary active oligopeptide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of an oligopeptide or oligopeptides from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport]
subset: gosubset_prok
synonym: "oligopeptide porter activity" RELATED []
is_a: GO:0015198 ! oligopeptide transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015323
name: type V protein secretor activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport]
comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
is_obsolete: true

[Term]
id: GO:0015324
name: peptide-acetyl-CoA secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of peptide-acetyl-CoA from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
synonym: "peptide-acetyl-CoA transporter activity" RELATED []
is_a: GO:0015197 ! peptide transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015325
name: acetyl-CoA:CoA antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out)." [TC:2.A.1.25.1]
is_a: GO:0008521 ! acetyl-CoA transporter activity
is_a: GO:0015300 ! solute:solute antiporter activity
is_a: GO:0015324 ! peptide-acetyl-CoA secondary active transmembrane transporter activity

[Term]
id: GO:0015326
name: cationic amino acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a positively charged amino acid from one side of the membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005275 ! amine transmembrane transporter activity
is_a: GO:0008324 ! cation transmembrane transporter activity

[Term]
id: GO:0015327
name: cystine:glutamate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out)." [TC:2.A.3.8.5]
is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity
is_a: GO:0005313 ! L-glutamate transmembrane transporter activity
is_a: GO:0015184 ! L-cystine transmembrane transporter activity
is_a: GO:0015300 ! solute:solute antiporter activity

[Term]
id: GO:0015328
name: cystine secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
synonym: "cystine porter activity" RELATED []
synonym: "cystinosin" NARROW []
synonym: "lysosomal cystine transporter" NARROW []
is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity
is_a: GO:0015184 ! L-cystine transmembrane transporter activity

[Term]
id: GO:0015330
name: high affinity glutamine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the high affinity transfer of glutamine from one side of the membrane to the other." [GOC:mtg_transport]
synonym: "high affinity glutamine permease activity" RELATED []
is_a: GO:0005287 ! high affinity basic amino acid transmembrane transporter activity
is_a: GO:0015186 ! L-glutamine transmembrane transporter activity

[Term]
id: GO:0015331
name: asparagine/glutamine permease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the stereospecific transfer of asparagine or glutamine across a biological membrane." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0015182
consider: GO:0015186
consider: GO:0022857

[Term]
id: GO:0015332
name: leucine/valine/isoleucine permease activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0005304
consider: GO:0015188
consider: GO:0015190
consider: GO:0022857

[Term]
id: GO:0015333
name: peptide:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in). Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement." [GOC:mtg_transport, TC:2.A.17.-.-]
subset: gosubset_prok
synonym: "peptide:proton symporter activity" EXACT []
is_a: GO:0015295 ! solute:hydrogen symporter activity
is_a: GO:0022897 ! proton-dependent peptide secondary active transmembrane transporter activity

[Term]
id: GO:0015334
name: high affinity oligopeptide transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of oligopeptide from one side of the membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:mtg_transport]
is_a: GO:0015198 ! oligopeptide transporter activity

[Term]
id: GO:0015335
name: heavy metal ion:hydrogen symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in), where Me2+ is Fe2+, Zn2+, Mn2+, Cu2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:2.A.55.2.1, TC:2.A.55.2.2]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "heavy metal ion:proton symporter activity" EXACT []
is_obsolete: true
consider: GO:0015295
consider: GO:0046873

[Term]
id: GO:0015336
name: high affinity metal ion uptake transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Fe2+, Mn2+, Zn2+, Cu2+, Cd2+, Ni2+ or Co2+." [TC:2.A.55.1.1]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
is_obsolete: true
consider: GO:0015295
consider: GO:0046873

[Term]
id: GO:0015337
name: low affinity metal ion uptake transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Mn2+ or Cu2+." [TC:2.A.55.1.2]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
is_obsolete: true
consider: GO:0015295
consider: GO:0046873

[Term]
id: GO:0015339
name: cobalt, zinc uptake permease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Co2+)(out) = (Zn2+ or Co2+)(in). The activity is driven by proton motive force, possibly by proton symport." [TC:2.A.4.2.1]
comment: This term was made obsolete because it represents more than one molecular function.
is_obsolete: true
consider: GO:0005385
consider: GO:0015087
consider: GO:0015563

[Term]
id: GO:0015340
name: zinc, cadmium uptake permease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Cd2+)(out) = (Zn2+ or Cd2+)(in). The activity is driven by proton motive force, possibly by proton symport." [TC:2.A.4.2.2]
comment: This term was made obsolete because it represents more than one molecular function.
is_obsolete: true
consider: GO:0005385
consider: GO:0015086
consider: GO:0015563

[Term]
id: GO:0015341
name: zinc efflux active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.4.1.4, TC:2.A.4.2.3]
synonym: "zinc efflux permease activity" BROAD []
is_a: GO:0005261 ! cation channel activity
is_a: GO:0005385 ! zinc ion transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0022883 ! zinc efflux transmembrane transporter activity

[Term]
id: GO:0015342
name: zinc, iron permease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Fe2+)(out) = (Zn2+ or Fe2+)(in), probably powered by proton motive force." [TC:2.A.5.-.-]
comment: This term was made obsolete because it represents more than one molecular function.
is_obsolete: true
consider: GO:0005381
consider: GO:0005385
consider: GO:0015563

[Term]
id: GO:0015343
name: siderophore-iron transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015236
alt_id: GO:0015237
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in)." [TC:2.A.1.16.-]
subset: gosubset_prok
synonym: "iron-siderophore transporter activity" EXACT []
synonym: "siderochrome-iron transporter activity" NARROW []
is_a: GO:0005381 ! iron ion transmembrane transporter activity
is_a: GO:0042927 ! siderophore transporter activity

[Term]
id: GO:0015344
name: siderophore-iron (ferrioxamine) uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in)." [TC:2.A.1.16.1]
synonym: "siderochrome-iron (ferrioxamine) uptake transporter" NARROW []
is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity

[Term]
id: GO:0015345
name: ferric enterobactin:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in)." [TC:2.A.1.16.2]
synonym: "ferric-enterobactin:proton symporter activity" EXACT []
is_a: GO:0015295 ! solute:hydrogen symporter activity
is_a: GO:0015620 ! ferric-enterobactin transmembrane transporter activity

[Term]
id: GO:0015346
name: ferric triacetylfusarinine C:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in)." [TC:2.A.1.16.3]
synonym: "ferric triacetylfusarinine C:proton symporter activity" EXACT []
is_a: GO:0015295 ! solute:hydrogen symporter activity
is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity
is_a: GO:0015621 ! ferric triacetylfusarinine C transmembrane transporter activity

[Term]
id: GO:0015347
name: sodium-independent organic anion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner." [GOC:go_curators]
is_a: GO:0008514 ! organic anion transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015348
name: prostaglandin/thromboxane transporter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0008028
consider: GO:0015132

[Term]
id: GO:0015349
name: thyroid hormone transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of thyroid hormones from one side of the membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:ai]
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015350
name: methotrexate transporter activity
namespace: molecular_function
def: "Enables the directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of, within or between cells. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase." [GOC:ai]
is_a: GO:0015238 ! drug transmembrane transporter activity

[Term]
id: GO:0015351
name: bilirubin secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of bilirubin from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]
synonym: "bilirubin porter activity" RELATED []
synonym: "bilitranslocase" NARROW []
is_a: GO:0015127 ! bilirubin transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015352
name: secondary active sterol transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of sterol from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport]
synonym: "sterol porter activity" RELATED []
is_a: GO:0015248 ! sterol transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015353
name: multidrug endosomal transmembrane transporter activity
namespace: molecular_function
is_a: GO:0015239 ! multidrug transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015354
name: polyspecific organic cation transmembrane transporter activity
namespace: molecular_function
is_a: GO:0008513 ! secondary active organic cation transmembrane transporter activity

[Term]
id: GO:0015355
name: secondary active monocarboxylate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism." [GOC:bf, GOC:jl]
synonym: "monocarboxylate porter activity" RELATED []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015356
name: monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0015129
consider: GO:0015130
consider: GO:0015562
consider: GO:0015563
consider: GO:0050833

[Term]
id: GO:0015358
name: amino acid/choline transmembrane transporter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0015171
consider: GO:0015220

[Term]
id: GO:0015360
name: acetate:hydrogen symporter activity
namespace: molecular_function
alt_id: GO:0015357
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in)." [TC:2.A.44.4.1]
synonym: "acetate:proton symporter activity" EXACT []
synonym: "hydrogen:acetate symporter activity" EXACT []
is_a: GO:0015295 ! solute:hydrogen symporter activity
is_a: GO:0043893 ! acetate:cation symporter activity

[Term]
id: GO:0015361
name: low affinity sodium:dicarboxylate symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.47.1.1]
synonym: "low affinity sodium:dicarboxylate cotransporter activity" BROAD []
is_a: GO:0017153 ! sodium:dicarboxylate symporter activity

[Term]
id: GO:0015362
name: high affinity sodium:dicarboxylate symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.47.1.4]
synonym: "high affinity sodium:dicarboxylate cotransporter activity" BROAD []
is_a: GO:0017153 ! sodium:dicarboxylate symporter activity

[Term]
id: GO:0015363
name: dicarboxylate (succinate/fumarate/malate) antiporter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0005310
consider: GO:0015138
consider: GO:0015140
consider: GO:0015141
consider: GO:0015297

[Term]
id: GO:0015364
name: dicarboxylate:inorganic phosphate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + inorganic phosphate(in) = dicarboxylate(in) + inorganic phosphate(out)." [TC:2.A.29.2.3]
is_a: GO:0015114 ! phosphate transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0015366
name: malate:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in)." [TC:2.A.16.2.1]
synonym: "malate:proton symporter activity" EXACT []
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015140 ! malate transmembrane transporter activity
is_a: GO:0015295 ! solute:hydrogen symporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015367
name: oxoglutarate:malate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out)." [TC:2.A.29.2.1]
xref: Reactome:23001 "oxoglutarate:malate antiporter activity"
is_a: GO:0015140 ! malate transmembrane transporter activity
is_a: GO:0015301 ! anion:anion antiporter activity

[Term]
id: GO:0015368
name: calcium:cation antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in)." [TC:2.A.19.-.-]
subset: gosubset_prok
is_a: GO:0015491 ! cation:cation antiporter activity

[Term]
id: GO:0015369
name: calcium:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)." [TC:2.A.19.2.-]
subset: gosubset_prok
synonym: "calcium:proton antiporter activity" EXACT []
is_a: GO:0015368 ! calcium:cation antiporter activity
is_a: GO:0051139 ! metal ion:hydrogen antiporter activity

[Term]
id: GO:0015370
name: solute:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in)." [GOC:ai]
subset: gosubset_prok
synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW []
is_a: GO:0015294 ! solute:cation symporter activity

[Term]
id: GO:0015371
name: galactose:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-]
is_a: GO:0005354 ! galactose transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0015372
name: glutamate/aspartate:sodium symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (glutamate or aspartate)(out) + Na+(out) = (glutamate or aspartate)(in) + Na+(in)." [TC:2.A.23.1.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0005283
consider: GO:0005313
consider: GO:0015183

[Term]
id: GO:0015373
name: monovalent anion:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent anion(out) + Na+(out) = monovalent anion(in) + Na+(in)." [TC:2.A.21.5.-]
is_a: GO:0015296 ! anion:cation symporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0015374
name: neutral, cationic amino acid:sodium:chloride symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/cationic amino acid(out) + Na+(out) + Cl-(out) = neutral/cationic amino acid(in) + Na+(in) + Cl-(in)." [TC:2.A.22.2.3]
is_a: GO:0005283 ! sodium:amino acid symporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity

[Term]
id: GO:0015375
name: glycine:sodium symporter activity
namespace: molecular_function
alt_id: GO:0015656
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in)." [GOC:ai]
is_a: GO:0005283 ! sodium:amino acid symporter activity
is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity
is_a: GO:0015187 ! glycine transmembrane transporter activity

[Term]
id: GO:0015376
name: betaine/GABA:sodium symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (betaine or gamma-aminobutyric acid)(out) + Na+(out) = (betaine or gamma-aminobutyric acid)(in) + Na+(in)." [TC:2.A.22.3.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0005332
consider: GO:0015185
consider: GO:0015199
consider: GO:0015370

[Term]
id: GO:0015377
name: cation:chloride symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [TC:2.A.30.-.-]
synonym: "cation:chloride cotransporter activity" BROAD []
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015378
name: sodium:chloride symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in)." [TC:2.A.30.4.-]
is_a: GO:0015377 ! cation:chloride symporter activity

[Term]
id: GO:0015379
name: potassium:chloride symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)." [TC:2.A.30.5.-]
is_a: GO:0015377 ! cation:chloride symporter activity

[Term]
id: GO:0015380
name: anion exchanger activity
namespace: molecular_function
alt_id: GO:0015384
synonym: "bicarbonate:chloride antiporter" NARROW []
is_a: GO:0015301 ! anion:anion antiporter activity

[Term]
id: GO:0015381
name: high affinity sulfate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the secondary active high affinity transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. In high affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations." [GOC:mtg_transport]
synonym: "high affinity sulfate permease activity" RELATED []
synonym: "high affinity sulphate permease activity" EXACT []
is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity

[Term]
id: GO:0015382
name: sodium:sulfate symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in)." [TC:2.A.47.1.2]
synonym: "sodium:sulfate cotransporter activity" BROAD []
synonym: "sodium:sulphate symporter activity" EXACT []
is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015383
name: sulfate:bicarbonate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out)." [TC:2.A.53.2.2]
synonym: "sulphate:bicarbonate antiporter activity" EXACT []
is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity
is_a: GO:0015106 ! bicarbonate transmembrane transporter activity
is_a: GO:0015301 ! anion:anion antiporter activity

[Term]
id: GO:0015385
name: sodium:hydrogen antiporter activity
namespace: molecular_function
alt_id: GO:0015502
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-]
subset: gosubset_prok
synonym: "pH-dependent sodium:hydrogen antiporter activity" NARROW []
synonym: "pH-dependent sodium:proton antiporter activity" NARROW []
synonym: "sodium/hydrogen antiporter activity" EXACT []
synonym: "sodium:hydrogen exchange activity" EXACT []
synonym: "sodium:hydrogen exchanger" EXACT []
synonym: "sodium:proton antiporter activity" EXACT []
is_a: GO:0005451 ! monovalent cation:hydrogen antiporter activity

[Term]
id: GO:0015386
name: potassium:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in)." [TC:2.A.37.-.-]
subset: gosubset_prok
synonym: "potassium:proton antiporter activity" EXACT []
is_a: GO:0005451 ! monovalent cation:hydrogen antiporter activity
is_a: GO:0022821 ! potassium ion antiporter activity

[Term]
id: GO:0015387
name: potassium:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + H+(out) = K+(in) + H+(in)." [TC:2.A.38.-.-]
synonym: "potassium:proton symporter activity" EXACT []
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015295 ! solute:hydrogen symporter activity
is_a: GO:0022820 ! potassium ion symporter activity

[Term]
id: GO:0015388
name: potassium uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of potassium from the outside of a cell to the inside of the cell across a membrane: K+(out) + energy = K+(in)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.72.2.-]
synonym: "potassium uptake permease activity" EXACT []
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0015563 ! uptake transmembrane transporter activity

[Term]
id: GO:0015389
name: pyrimidine- and adenine-specific:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenine)(out) + Na+(out) = (pyrimidine nucleoside or adenine)(in) + Na+(in)." [TC:2.A.41.2.3]
is_a: GO:0005345 ! purine transmembrane transporter activity
is_a: GO:0005350 ! pyrimidine transmembrane transporter activity
is_a: GO:0005415 ! nucleoside:sodium symporter activity

[Term]
id: GO:0015390
name: purine-specific nucleoside:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in)." [TC:2.A.41.2.1]
is_a: GO:0005415 ! nucleoside:sodium symporter activity

[Term]
id: GO:0015391
name: nucleobase:cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015205 ! nucleobase transmembrane transporter activity
is_a: GO:0015294 ! solute:cation symporter activity

[Term]
id: GO:0015393
name: uracil/uridine permease activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0015210
consider: GO:0015213
consider: GO:0022857

[Term]
id: GO:0015394
name: uridine:hydrogen ion symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uridine(out) + H+(out) = uridine(in) + H+(in)." [GOC:mtg_transport]
synonym: "nucleoside (uridine) permease activity" RELATED []
is_a: GO:0005350 ! pyrimidine transmembrane transporter activity
is_a: GO:0015213 ! uridine transmembrane transporter activity
is_a: GO:0015391 ! nucleobase:cation symporter activity
is_a: GO:0015506 ! nucleoside:hydrogen symporter activity

[Term]
id: GO:0015395
name: nucleoside transmembrane transporter activity, down a concentration gradient
namespace: molecular_function
def: "Catalysis of the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient." [PMID:10353709, PMID:11749958, PMID:12446811]
synonym: "equilibrative nucleoside transporter activity" EXACT []
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015396
name: equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-sensitive activity
namespace: molecular_function
is_a: GO:0015395 ! nucleoside transmembrane transporter activity, down a concentration gradient

[Term]
id: GO:0015397
name: equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-insensitive activity
namespace: molecular_function
is_a: GO:0015395 ! nucleoside transmembrane transporter activity, down a concentration gradient

[Term]
id: GO:0015398
name: high affinity secondary active ammonium transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015399
name: primary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources." [GOC:mtg_transport, ISBN:0815340729, TC:3.-.-.-.-]
subset: gosubset_prok
synonym: "primary active transporter" RELATED []
xref: TC:3
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0015400
name: low affinity secondary active ammonium transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729]
synonym: "low affinity ammonium transmembrane transporter activity" RELATED []
is_a: GO:0008519 ! ammonium transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015401
name: urea:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in)." [TC:2.A.21.6.1]
synonym: "urea active transmembrane transporter activity" EXACT []
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0015403
name: thiamin uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of thiamin from the outside of a cell to the inside across a membrane." [GOC:mtg_transport]
synonym: "thiamine uptake transporter activity" EXACT []
is_a: GO:0015234 ! thiamin transmembrane transporter activity
is_a: GO:0015563 ! uptake transmembrane transporter activity

[Term]
id: GO:0015404
name: ion-gradient-driven energizer activity
namespace: molecular_function
subset: gosubset_prok
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015405
name: P-P-bond-hydrolysis-driven transmembrane transporter activity
namespace: molecular_function
def: "Primary active transport of a solute across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.A.-.-.-]
subset: gosubset_prok
synonym: "P-P-bond-hydrolysis-driven transporters" EXACT []
xref: TC:3.A
is_a: GO:0015399 ! primary active transmembrane transporter activity

[Term]
id: GO:0015406
name: ABC-type uptake permease activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping.
is_obsolete: true
consider: GO:0042626
consider: GO:0043190

[Term]
id: GO:0015407
name: monosaccharide-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported." [EC:3.6.3.17]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (monosaccharide-importing)" EXACT [EC:3.6.3.17]
synonym: "monosaccharide ABC transporter" NARROW []
synonym: "monosaccharide-importing ATPase activity" NARROW []
xref: EC:3.6.3.17
xref: MetaCyc:3.6.3.17-RXN
is_a: GO:0015145 ! monosaccharide transmembrane transporter activity
is_a: GO:0015608 ! carbohydrate-importing ATPase activity

[Term]
id: GO:0015408
name: ferric-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)." [EC:3.6.3.30]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (ferric-ion-transporting)" EXACT [EC:3.6.3.30]
synonym: "Fe3+-transporting ATPase activity" EXACT [EC:3.6.3.30]
synonym: "ferric ABC transporter" NARROW []
synonym: "ferric transporting ATPase activity" EXACT []
xref: EC:3.6.3.30
xref: MetaCyc:3.6.3.30-RXN
is_a: GO:0015091 ! ferric iron transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0015410
name: manganese-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in)." [EC:3.6.3.35]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ABC-type manganese permease complex" RELATED [EC:3.6.3.35]
synonym: "ATP phosphohydrolase (manganese-importing)" EXACT [EC:3.6.3.35]
synonym: "manganese ABC transporter" NARROW []
synonym: "manganese transporting ATPase activity" EXACT []
xref: EC:3.6.3.35
xref: MetaCyc:3.6.3.35-RXN
is_a: GO:0005384 ! manganese ion transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0015411
name: taurine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in)." [EC:3.6.3.36]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ATP phosphohydrolase (taurine-importing)" EXACT [EC:3.6.3.36]
synonym: "taurine (2-aminoethane sulfonate) porter activity" EXACT []
synonym: "taurine ABC transporter" NARROW []
xref: EC:3.6.3.36
xref: MetaCyc:3.6.3.36-RXN
is_a: GO:0005368 ! taurine transmembrane transporter activity
is_a: GO:0015424 ! amino acid-transporting ATPase activity

[Term]
id: GO:0015412
name: molybdate transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in)." [EC:3.6.3.29]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (molybdate-importing)" EXACT [EC:3.6.3.29]
synonym: "molybdate ABC transporter" NARROW []
synonym: "molybdate porter activity" EXACT []
synonym: "molybdate transporting ATPase activity" EXACT []
synonym: "molybdate-transporting ATPase activity" EXACT [EC:3.6.3.29]
xref: EC:3.6.3.29
xref: MetaCyc:3.6.3.29-RXN
is_a: GO:0015098 ! molybdate ion transmembrane transporter activity
is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity

[Term]
id: GO:0015413
name: nickel-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in)." [EC:3.6.3.24]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ATP phosphohydrolase (nickel-importing)" EXACT [EC:3.6.3.24]
synonym: "nickel ABC transporter" NARROW []
synonym: "nickel porter activity" EXACT []
synonym: "nickel transporting ATPase activity" EXACT []
xref: EC:3.6.3.24
xref: MetaCyc:3.6.3.24-RXN
is_a: GO:0015099 ! nickel ion transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0015414
name: nitrate transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nitrate(out) = ADP + phosphate + nitrate(in)." [EC:3.6.3.26]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ATP phosphohydrolase (nitrate-importing)" EXACT [EC:3.6.3.26]
synonym: "nitrate ABC transporter" NARROW []
synonym: "nitrate transporting ATPase activity" EXACT []
synonym: "nitrate-transporting ATPase activity" EXACT [EC:3.6.3.26]
xref: EC:3.6.3.26
xref: MetaCyc:3.6.3.26-RXN
is_a: GO:0015112 ! nitrate transmembrane transporter activity
is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity

[Term]
id: GO:0015415
name: phosphate transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in)." [EC:3.6.3.27]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ABC phosphate transporter activity" NARROW [EC:3.6.3.27]
synonym: "ATP phosphohydrolase (phosphate-importing)" EXACT [EC:3.6.3.27]
synonym: "phosphate ABC transporter" NARROW []
synonym: "phosphate porter activity" EXACT []
synonym: "phosphate transporting ATPase activity" EXACT []
synonym: "phosphate-transporting ATPase activity" EXACT [EC:3.6.3.27]
xref: EC:3.6.3.27
xref: MetaCyc:3.6.3.27-RXN
is_a: GO:0015114 ! phosphate transmembrane transporter activity
is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity

[Term]
id: GO:0015416
name: phosphonate transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [EC:3.6.3.28]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ATP phosphohydrolase (phosphonate-transporting)" EXACT [EC:3.6.3.28]
synonym: "phosphonate ABC transporter" NARROW []
synonym: "phosphonate transporting ATPase activity" EXACT []
synonym: "phosphonate-transporting ATPase activity" EXACT [EC:3.6.3.28]
xref: EC:3.6.3.28
xref: MetaCyc:3.6.3.28-RXN
is_a: GO:0015604 ! phosphonate transmembrane transporter activity
is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity
is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity

[Term]
id: GO:0015417
name: polyamine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)." [EC:3.6.3.31]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (polyamine-importing) activity" EXACT [EC:3.6.3.31]
synonym: "polyamine ABC transporter" NARROW []
synonym: "polyamine porter activity" EXACT []
synonym: "polyamine-importing ATPase activity" NARROW []
xref: EC:3.6.3.31
xref: MetaCyc:3.6.3.31-RXN
is_a: GO:0015203 ! polyamine transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015418
name: quaternary-ammonium-compound-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in)." [EC:3.6.3.32]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (quaternary-amine-importing) activity" EXACT [EC:3.6.3.32]
synonym: "glycine betaine/proline porter activity" RELATED []
synonym: "quaternary amine uptake transporter activity" EXACT []
synonym: "quaternary-amine-transporting ATPase activity" EXACT []
synonym: "quaternary-ammonium-compound ABC transporter" NARROW []
xref: EC:3.6.3.32
xref: MetaCyc:3.6.3.32-RXN
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015419
name: sulfate transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in)." [EC:3.6.3.25]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (sulfate-importing) activity" EXACT [EC:3.6.3.25]
synonym: "sulfate ABC transporter" NARROW []
synonym: "sulfate transporting ATPase activity" EXACT []
synonym: "sulfate-transporting ATPase activity" EXACT [EC:3.6.3.25]
synonym: "sulfate/thiosulfate porter activity" EXACT []
synonym: "sulphate transporting ATPase activity" EXACT []
synonym: "sulphate-transporting ATPase activity" EXACT []
xref: EC:3.6.3.25
xref: MetaCyc:3.6.3.25-RXN
is_a: GO:0015116 ! sulfate transmembrane transporter activity
is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity

[Term]
id: GO:0015420
name: cobalamin-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + cobalamin(out) = ADP + phosphate + cobalamin(in). Cobalamin = vitamin B12." [EC:3.6.3.33]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (vitamin B12-importing)" EXACT [EC:3.6.3.33]
synonym: "cobalamin ABC transporter" NARROW []
synonym: "cobalamin porter activity" EXACT []
synonym: "vitamin B12 porter activity" EXACT []
synonym: "vitamin B12-transporting ATPase activity" EXACT []
xref: EC:3.6.3.33
xref: MetaCyc:3.6.3.33-RXN
is_a: GO:0015235 ! cobalamin transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015421
name: oligopeptide-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)." [EC:3.6.3.23]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (oligopeptide-importing)" EXACT [EC:3.6.3.23]
synonym: "oligopeptide ABC transporter" NARROW []
synonym: "oligopeptide permease activity" RELATED [EC:3.6.3.23]
xref: EC:3.6.3.23
xref: MetaCyc:3.6.3.23-RXN
is_a: GO:0015198 ! oligopeptide transporter activity
is_a: GO:0015440 ! peptide-transporting ATPase activity

[Term]
id: GO:0015422
name: oligosaccharide-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in)." [EC:3.6.3.18]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (disaccharide-importing)" EXACT [EC:3.6.3.18]
synonym: "oligosaccharide ABC transporter" NARROW []
xref: EC:3.6.3.18
xref: MetaCyc:3.6.3.18-RXN
is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015423
name: maltose-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in)." [EC:3.6.3.19]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (maltose-importing)" EXACT [EC:3.6.3.19]
synonym: "maltose ABC transporter" NARROW []
xref: EC:3.6.3.19
xref: MetaCyc:3.6.3.19-RXN
is_a: GO:0005363 ! maltose transmembrane transporter activity
is_a: GO:0015422 ! oligosaccharide-transporting ATPase activity

[Term]
id: GO:0015424
name: amino acid-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out)." [GOC:ai, GOC:mah]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "amino acid ABC transporter" NARROW []
is_a: GO:0015171 ! amino acid transmembrane transporter activity
is_a: GO:0031263 ! amine-transporting ATPase activity

[Term]
id: GO:0015425
name: nonpolar-amino acid-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:3.6.3.22]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ATP phosphohydrolase (nonpolar-amino-acid-transporting) activity" EXACT [EC:3.6.3.22]
synonym: "leucine/isoleucine/valine porter activity" RELATED []
synonym: "nonpolar amino acid-transporting ATPase activity" EXACT []
synonym: "nonpolar-amino acid ABC transporter" NARROW []
synonym: "nonpolar-amino-acid-transporting ATPase activity" EXACT []
xref: EC:3.6.3.22
xref: MetaCyc:3.6.3.22-RXN
is_a: GO:0015424 ! amino acid-transporting ATPase activity

[Term]
id: GO:0015426
name: polar-amino acid-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (polar-amino-acid-importing) activity" EXACT [EC:3.6.3.21]
synonym: "cystine/diaminopimelate porter activity" RELATED []
synonym: "glutamate/aspartate porter activity" RELATED []
synonym: "histidine permease activity" NARROW [EC:3.6.3.21]
synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED []
synonym: "polar amino acid uptake transporter activity" EXACT []
synonym: "polar amino acid-importing ATPase activity" EXACT []
synonym: "polar-amino acid ABC transporter" NARROW []
synonym: "polar-amino acid-importing ATPase activity" EXACT []
synonym: "polar-amino-acid-transporting ATPase activity" EXACT [EC:3.6.3.21]
xref: EC:3.6.3.21
xref: MetaCyc:3.6.3.21-RXN
is_a: GO:0015424 ! amino acid-transporting ATPase activity

[Term]
id: GO:0015427
name: ABC-type efflux porter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping.
is_obsolete: true
consider: GO:0042626
consider: GO:0043190

[Term]
id: GO:0015428
name: type I protein secretor activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport]
comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
is_obsolete: true

[Term]
id: GO:0015429
name: peroxisomal fatty acyl transporter
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a gene product and it contains both component and function information.
is_obsolete: true
consider: GO:0005777
consider: GO:0015246

[Term]
id: GO:0015430
name: glycerol-3-phosphate-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in)." [EC:3.6.3.20]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (glycerol-3-phosphate-importing)" EXACT [EC:3.6.3.20]
synonym: "glycerol-3-phosphate ABC transporter" NARROW []
xref: EC:3.6.3.20
xref: MetaCyc:3.6.3.20-RXN
is_a: GO:0015169 ! glycerol-3-phosphate transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015431
name: glutathione S-conjugate-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) = ADP + phosphate + glutathione S-conjugate(out)." [GOC:jl, PMID:1455517]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ATP-dependent glutathione S-conjugate export pump" EXACT []
synonym: "conjugate transporter activity" BROAD []
synonym: "GS-X pump" EXACT []
synonym: "MRP1/GS-X pump" EXACT []
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015432
name: bile acid-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O = bile acid(out) + ADP + phosphate." [TC:3.A.1.207.2]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "bile acid porter activity" NARROW []
xref: Reactome:23506 "bile acid-exporting ATPase activity"
is_a: GO:0015125 ! bile acid transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015433
name: peptide antigen-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate." [TC:3.A.1.209.1]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "major histocompatibility peptide transporter activity" EXACT []
synonym: "peptide antigen ABC transporter" NARROW []
synonym: "peptide antigen transporter activity" BROAD []
is_a: GO:0015440 ! peptide-transporting ATPase activity

[Term]
id: GO:0015434
name: cadmium-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole)." [EC:3.6.3.46]
subset: gosubset_prok
synonym: "ATP phosphohydrolase (heavy-metal-exporting)" EXACT [EC:3.6.3.46]
synonym: "cadmium ABC transporter" NARROW []
synonym: "yeast cadmium factor" RELATED [EC:3.6.3.46]
xref: EC:3.6.3.46
xref: MetaCyc:3.6.3.46-RXN
is_a: GO:0015086 ! cadmium ion transmembrane transporter activity

[Term]
id: GO:0015435
name: ABC-type efflux permease activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping.
is_obsolete: true
consider: GO:0042626
consider: GO:0043190

[Term]
id: GO:0015436
name: capsular-polysaccharide-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out)." [EC:3.6.3.38]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (capsular-polysaccharide-exporting)" EXACT [EC:3.6.3.38]
synonym: "capsular-polysaccharide ABC transporter" NARROW []
xref: EC:3.6.3.38
xref: MetaCyc:3.6.3.38-RXN
is_a: GO:0015161 ! capsular polysaccharide transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015437
name: lipopolysaccharide-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipopolysaccharide(in) = ADP + phosphate + lipopolysaccharide(out)." [EC:3.6.3.39]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (lipopolysaccharide-exporting)" EXACT [EC:3.6.3.39]
synonym: "lipopolysaccharide ABC transporter" NARROW []
synonym: "LPS-transporting ATPase activity" EXACT []
xref: EC:3.6.3.39
xref: MetaCyc:3.6.3.39-RXN
is_a: GO:0015221 ! lipopolysaccharide transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015438
name: teichoic-acid-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out)." [EC:3.6.3.40]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (teichoic-acid-exporting)" EXACT [EC:3.6.3.40]
synonym: "teichoic-acid ABC transporter" NARROW []
xref: EC:3.6.3.40
xref: MetaCyc:3.6.3.40-RXN
is_a: GO:0015162 ! teichoic acid transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015439
name: heme-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)." [EC:3.6.3.41]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (heme-exporting)" EXACT [EC:3.6.3.41]
synonym: "haem-transporting ATPase activity" EXACT []
synonym: "heme ABC transporter" NARROW []
xref: EC:3.6.3.41
xref: MetaCyc:3.6.3.41-RXN
is_a: GO:0015232 ! heme transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015440
name: peptide-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria." [EC:3.6.3.43]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (peptide-exporting)" EXACT [EC:3.6.3.43]
synonym: "peptide ABC transporter" NARROW []
xref: EC:3.6.3.43
xref: MetaCyc:3.6.3.43-RXN
is_a: GO:0015197 ! peptide transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015441
name: beta-glucan-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out)." [EC:3.6.3.42]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ATP phosphohydrolase (beta-glucan-exporting)" EXACT [EC:3.6.3.42]
synonym: "beta-glucan ABC transporter" NARROW []
xref: EC:3.6.3.42
xref: MetaCyc:3.6.3.42-RXN
is_a: GO:0015160 ! beta-glucan transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015442
name: hydrogen-/sodium-translocating ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + (Na+ or H+)(in) = ADP + phosphate + (Na+ or H+)(out)." [TC:3.A.2.-.-]
comment: This term was made obsolete because it is a redundant grouping term based on a TC-DB classification.
synonym: "proton-/sodium-translocating ATPase activity" EXACT []
is_obsolete: true
consider: GO:0008553
consider: GO:0008554

[Term]
id: GO:0015443
name: sodium-transporting two-sector ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out)." [EC:3.6.3.15]
comment: This term was made obsolete because it refers to a bifunctional gene product.
is_obsolete: true
consider: GO:0046932
consider: GO:0046962

[Term]
id: GO:0015444
name: magnesium-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in)." [EC:3.6.3.2]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (Mg2+-importing)" EXACT [EC:3.6.3.2]
synonym: "magnesium importing ATPase activity" EXACT []
synonym: "magnesium-translocating P-type ATPase activity" RELATED [EC:3.6.3.2]
synonym: "Mg(2+)-importing ATPase activity" EXACT [EC:3.6.3.2]
synonym: "Mg2+-importing ATPase activity" EXACT [EC:3.6.3.2]
synonym: "mg2+-importing ATPase activity" EXACT [EC:3.6.3.2]
xref: EC:3.6.3.2
xref: MetaCyc:3.6.3.2-RXN
is_a: GO:0015095 ! magnesium ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

[Term]
id: GO:0015445
name: silver-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ag+(in) = ADP + phosphate + Ag+(out)." [EC:3.6.3.53]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "Ag+-exporting ATPase activity" EXACT [EC:3.6.3.53]
synonym: "ATP phosphohydrolase (Ag+-exporting)" EXACT [EC:3.6.3.53]
synonym: "silver exporting ATPase activity" EXACT []
xref: EC:3.6.3.53
xref: MetaCyc:3.6.3.53-RXN
is_a: GO:0015080 ! silver ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

[Term]
id: GO:0015446
name: arsenite transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out)." [EC:3.6.3.16]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "arsenical pump-driving ATPase activity" EXACT [EC:3.6.3.16]
synonym: "arsenical resistance ATPase activity" EXACT [EC:3.6.3.16]
synonym: "arsenical resistance efflux pump" EXACT []
synonym: "arsenite ABC transporter" NARROW []
synonym: "arsenite transporting ATPase activity" EXACT []
synonym: "arsenite-translocating ATPase activity" EXACT [EC:3.6.3.16]
synonym: "arsenite-transporting ATPase activity" EXACT [EC:3.6.3.16]
synonym: "ATP phosphohydrolase (arsenite-exporting) activity" EXACT [EC:3.6.3.16]
xref: EC:3.6.3.16
xref: MetaCyc:3.6.3.16-RXN
is_a: GO:0008490 ! arsenite secondary active transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity
is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity

[Term]
id: GO:0015447
name: type II protein secretor activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport]
comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
is_obsolete: true

[Term]
id: GO:0015448
name: type III protein (virulence-related) secretor activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport]
comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
is_obsolete: true

[Term]
id: GO:0015449
name: type IV protein (DNA-protein) secretor activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport]
comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved.
is_obsolete: true

[Term]
id: GO:0015450
name: P-P-bond-hydrolysis-driven protein transmembrane transporter activity
namespace: molecular_function
def: "Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "protein translocase activity" EXACT []
is_a: GO:0008320 ! protein transmembrane transporter activity
is_a: GO:0015405 ! P-P-bond-hydrolysis-driven transmembrane transporter activity
is_a: GO:0022884 ! macromolecule transmembrane transporter activity

[Term]
id: GO:0015451
name: decarboxylation-driven active transmembrane transporter activity
namespace: molecular_function
def: "Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.B.-.-.-]
subset: gosubset_prok
synonym: "Decarboxylation-driven transporters" RELATED []
xref: TC:3.B
is_a: GO:0015399 ! primary active transmembrane transporter activity

[Term]
id: GO:0015452
name: methyl transfer-driven active transmembrane transporter activity
namespace: molecular_function
def: "Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.C.-.-.-]
synonym: "Methyltransfer-driven transporters" EXACT []
xref: TC:3.C
is_a: GO:0015399 ! primary active transmembrane transporter activity

[Term]
id: GO:0015453
name: oxidoreduction-driven active transmembrane transporter activity
namespace: molecular_function
def: "Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-]
subset: gosubset_prok
synonym: "Oxidoreduction-driven transporters" EXACT []
xref: TC:3.D
is_a: GO:0015399 ! primary active transmembrane transporter activity

[Term]
id: GO:0015454
name: light-driven active transmembrane transporter activity
namespace: molecular_function
def: "Primary active transport of a solute across a membrane, driven by light. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.E.-.-.-]
synonym: "Light absorption-driven transporters" EXACT []
synonym: "light-driven pumps" EXACT []
xref: TC:3.E
is_a: GO:0015399 ! primary active transmembrane transporter activity

[Term]
id: GO:0015459
name: potassium channel regulator activity
namespace: molecular_function
def: "Modulates the activity of a potassium channel." [GOC:mah]
is_a: GO:0016247 ! channel regulator activity

[Term]
id: GO:0015461
name: endosomal oligosaccharide transporter
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
is_obsolete: true
consider: GO:0005768
consider: GO:0015157

[Term]
id: GO:0015462
name: protein-transmembrane transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in)." [EC:3.6.1.3, GOC:jl]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "pilin/fimbrilin exporter activity" NARROW []
synonym: "protein ABC transporter" NARROW []
synonym: "protein-transporting ATPase activity" EXACT []
is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015464
name: acetylcholine receptor activity
namespace: molecular_function
def: "Combining with acetylcholine to initiate a change in cell activity." [GOC:jl]
is_a: GO:0004888 ! transmembrane receptor activity
is_a: GO:0030594 ! neurotransmitter receptor activity
is_a: GO:0042166 ! acetylcholine binding

[Term]
id: GO:0015465
name: lysin activity
namespace: molecular_function
def: "OBSOLETE. An agent that can lyse cells." [ISBN:0198547684]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
consider: GO:0019835

[Term]
id: GO:0015466
name: autolysin activity
namespace: molecular_function
def: "OBSOLETE. An agent that can lyse the cell in which it is synthesized." [GOC:ma]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
consider: GO:0019835

[Term]
id: GO:0015467
name: G-protein activated inward rectifier potassium channel activity
namespace: molecular_function
alt_id: GO:0015273
def: "Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force." [GOC:cb, GOC:mah]
synonym: "G protein activated inward rectifier potassium channel activity" EXACT []
synonym: "G protein enhanced inward rectifier potassium channel activity" EXACT []
synonym: "G-protein enhanced inward rectifier potassium channel activity" EXACT []
synonym: "G-protein-activated inward rectifier potassium channel activity" EXACT []
synonym: "G-protein-enhanced inward rectifier potassium channel activity" EXACT []
is_a: GO:0005242 ! inward rectifier potassium channel activity

[Term]
id: GO:0015468
name: colicin
namespace: molecular_function
def: "OBSOLETE. Plasmid-encoded bacteriocins which are produced by enteric bacteria. Exert a lethal effect on other bacteria including E. coli strains that lack the Col plasmid. Bind to a cell surface receptor and are transported into the periplasm via an energy-dependent process involving a TonB- or TolA-dependent hetero-oligomeric protein complex. Some colicins kill their target cell by inserting into the cytoplasmic membrane where they form voltage-sensitive (trans-negative) channels that depolarize and deenergize the cell, and thereby kill it." [TC:1.C.1.-.-]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
consider: GO:0005102
consider: GO:0005198
consider: GO:0009405
consider: GO:0019835
consider: GO:0046930
consider: GO:0046931
consider: GO:0050827

[Term]
id: GO:0015469
name: channel-forming toxin activity
namespace: molecular_function
def: "OBSOLETE. A toxin that exerts its effects by forming a channel in a membrane that allows the unregulated passage of substances into and out of the cell." [GOC:ai]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
consider: GO:0009405
consider: GO:0015267
consider: GO:0046930
consider: GO:0046931
consider: GO:0050827

[Term]
id: GO:0015470
name: bacteriocin activity
namespace: molecular_function
def: "OBSOLETE. Polypeptide antibiotic secreted by bacteria and able to kill bacteria of susceptible strains after absorption by specific cell surface receptor." [ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0005102
consider: GO:0019835

[Term]
id: GO:0015471
name: nucleoside-specific channel forming porin activity
namespace: molecular_function
def: "Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport]
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015472
name: fimbrium-specific chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in the correct assembly of fimbria, extracellular organelles that are used to attach a bacterial cell to a surface, but is not a component of the fimbrium when performing its normal biological function." [GOC:jl, GOC:rb, PMID:7906046]
comment: This term was made obsolete because it refers to a class of proteins and a biological process rather than a molecular function.
is_obsolete: true
consider: GO:0009297
consider: GO:0030674
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0015473
name: fimbrial usher porin activity
namespace: molecular_function
def: "A porin that acts in the assembly of fimbria together with fimbrial chaperone." [TC:1.B.11.-.-]
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015474
name: autotransporter activity
namespace: molecular_function
def: "Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.12.-.-]
subset: gosubset_prok
is_a: GO:0008565 ! protein transporter activity
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015475
name: adhesin autotransporter activity
namespace: molecular_function
def: "Catalysis of the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015474 ! autotransporter activity

[Term]
id: GO:0015476
name: hemaglutinin autotransporter activity
namespace: molecular_function
def: "Catalysis of the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015474 ! autotransporter activity

[Term]
id: GO:0015477
name: receptor porin activity
namespace: molecular_function
def: "OBSOLETE. A porin of the bacterial outer membrane that forms transmembrane pores and transports relatively large molecules from the external milieu to the periplasm in an energized process. Energizing of transport across the outer membrane requires a heterotrimeric complex of proteins, the TonB-ExbB-ExbD complex, or in some cases, the TolA-TolQ-TolR complex. Energizing requires proton motive force across the cytoplasmic membrane." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.13.-.-]
comment: This term was made obsolete because it combines two functions that are not linked.
is_obsolete: true

[Term]
id: GO:0015478
name: oligosaccharide transporting porin activity
namespace: molecular_function
def: "Catalysis of the transfer of oligosaccharide, sized less than 1000 Da, from one side of the membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport]
synonym: "raffinose porin" NARROW []
is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015479
name: outer membrane exporter porin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
is_obsolete: true
consider: GO:0009279
consider: GO:0015288

[Term]
id: GO:0015480
name: secretin (sensu Bacteria)
namespace: molecular_function
def: "OBSOLETE. Secretins are Gram-negative bacterial outer membrane proteins that form multimeric pores through which macromolecules, usually proteins, can pass. Form homomultimeric ring structures, 10-20 subunits per complex, with large central pores (inner diameters of 5-10 nm)." [TC:1.B.22.-.-]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
consider: GO:0008565
consider: GO:0045203

[Term]
id: GO:0015481
name: maltose transporting porin activity
namespace: molecular_function
def: "Catalysis of the transfer of maltose from one side of the membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport]
subset: gosubset_prok
synonym: "maltoporin" EXACT []
xref: Wikipedia:Maltoporin
is_a: GO:0005363 ! maltose transmembrane transporter activity
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015482
name: voltage-gated anion channel porin activity
namespace: molecular_function
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because it wrongly combines voltage-gated anion channel activity and porin activity.
synonym: "voltage-dependent anion channel porin activity" EXACT []
is_obsolete: true

[Term]
id: GO:0015483
name: long-chain fatty acid transporting porin activity
namespace: molecular_function
def: "Catalysis of the transfer of long-chain fatty acids from one side of the membrane to the other. Long-chain fatty acids have a chain length of greater than 12 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport]
is_a: GO:0005324 ! long-chain fatty acid transporter activity
is_a: GO:0015288 ! porin activity

[Term]
id: GO:0015484
name: hemolysin activity
namespace: molecular_function
def: "OBSOLETE. Any substance that causes the lysis of red blood cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0019836

[Term]
id: GO:0015485
name: cholesterol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0032934 ! sterol binding

[Term]
id: GO:0015486
name: glycoside-pentoside-hexuronide:cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+." [TC:2.A.2.-.-]
is_a: GO:0005402 ! cation:sugar symporter activity

[Term]
id: GO:0015487
name: melibiose:monovalent cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in)." [TC:2.A.2.1.1]
subset: gosubset_prok
synonym: "melibiose permease activity" RELATED []
is_a: GO:0015156 ! melibiose transmembrane transporter activity
is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity

[Term]
id: GO:0015488
name: glucuronide:monovalent cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in)." [TC:2.A.2.3.1]
synonym: "glucuronoside permease activity" RELATED []
is_a: GO:0015164 ! glucuronoside transmembrane transporter activity
is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity

[Term]
id: GO:0015489
name: putrescine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of putrescine from one side of the membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015203 ! polyamine transmembrane transporter activity

[Term]
id: GO:0015490
name: cadaverine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of cadaverine, 1,5-pentanediamine, from one side of the membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005275 ! amine transmembrane transporter activity

[Term]
id: GO:0015491
name: cation:cation antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015298 ! solute:cation antiporter activity

[Term]
id: GO:0015492
name: phenylalanine:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in)." [TC:2.A.3.1.1]
synonym: "phenylalanine:proton symporter activity" EXACT []
is_a: GO:0015192 ! L-phenylalanine transmembrane transporter activity
is_a: GO:0015494 ! aromatic amino acid:hydrogen symporter activity

[Term]
id: GO:0015493
name: lysine:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in)." [TC:2.A.3.1.2]
synonym: "lysine:proton symporter activity" EXACT []
is_a: GO:0005280 ! hydrogen:amino acid symporter activity
is_a: GO:0015189 ! L-lysine transmembrane transporter activity

[Term]
id: GO:0015494
name: aromatic amino acid:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in)." [TC:2.A.3.1.3]
synonym: "aromatic amino acid:proton symporter activity" EXACT []
is_a: GO:0005280 ! hydrogen:amino acid symporter activity
is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity

[Term]
id: GO:0015495
name: gamma-aminobutyric acid:hydrogen symporter activity
namespace: molecular_function
alt_id: GO:0005331
alt_id: GO:0015329
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in)." [TC:2.A.18.5.1, TC:2.A.3.1.4, TC:2.A.3.4.2]
comment: See also the molecular function term 'neurotransmitter transporter activity ; GO:0005326'.
synonym: "4-aminobutanoate:hydrogen symporter activity" EXACT []
synonym: "4-aminobutanoate:proton symporter activity" EXACT []
synonym: "4-aminobutyrate:hydrogen symporter activity" EXACT []
synonym: "4-aminobutyrate:proton symporter activity" EXACT []
synonym: "GABA:hydrogen symporter activity" EXACT []
synonym: "GABA:proton symporter activity" EXACT []
synonym: "gamma-aminobutyric acid permease activity" EXACT []
synonym: "gamma-aminobutyric acid:proton symporter activity" EXACT []
is_a: GO:0005280 ! hydrogen:amino acid symporter activity
is_a: GO:0015185 ! L-gamma-aminobutyric acid transmembrane transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0015496
name: putrescine:ornithine antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out)." [TC:2.A.3.2.1]
subset: gosubset_prok
synonym: "putrescine-ornithine antiporter activity" EXACT []
synonym: "putrescine/ornithine antiporter activity" EXACT []
synonym: "putrescine:hydrogen symporter activity" EXACT []
is_a: GO:0000064 ! L-ornithine transmembrane transporter activity
is_a: GO:0015300 ! solute:solute antiporter activity
is_a: GO:0015489 ! putrescine transmembrane transporter activity

[Term]
id: GO:0015498
name: pantothenate:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in)." [TC:2.A.21.1.1]
subset: gosubset_prok
is_a: GO:0015233 ! pantothenate transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0015499
name: formate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of formate from one side of the membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015500
name: threonine/serine:sodium symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (threonine or serine)(out) + Na+(out) = (threonine or serine)(in) + Na+(in)." [TC:2.A.23.4.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0005283
consider: GO:0015194
consider: GO:0015195

[Term]
id: GO:0015501
name: glutamate:sodium symporter activity
namespace: molecular_function
alt_id: GO:0008027
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)." [TC:2.A.27.1.1]
synonym: "sodium/excitatory glutamate cotransporter activity" BROAD []
synonym: "sodium/excitatory glutamate symporter activity" EXACT []
is_a: GO:0005283 ! sodium:amino acid symporter activity
is_a: GO:0005313 ! L-glutamate transmembrane transporter activity

[Term]
id: GO:0015503
name: glutathione-regulated potassium exporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state." [PMID:11053405, TC:2.A.37.1.1, TC:2.A.37.1.2]
subset: gosubset_prok
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015504
name: cytosine:hydrogen ion symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in)." [TC:2.A.39.1.1]
synonym: "cytosine permease activity" RELATED []
is_a: GO:0015209 ! cytosine transmembrane transporter activity
is_a: GO:0015391 ! nucleobase:cation symporter activity

[Term]
id: GO:0015505
name: uracil:cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uracil(out) + cation(out) = uracil(in) + cation(in)." [GOC:mtg_transport]
subset: gosubset_prok
synonym: "uracil permease activity" RELATED []
is_a: GO:0015210 ! uracil transmembrane transporter activity
is_a: GO:0015391 ! nucleobase:cation symporter activity

[Term]
id: GO:0015506
name: nucleoside:hydrogen symporter activity
namespace: molecular_function
alt_id: GO:0015536
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in)." [TC:2.A.1.10.1, TC:2.A.41.1.1]
synonym: "nucleoside permease activity" RELATED []
synonym: "nucleoside:hydrogen ion symporter activity" EXACT []
synonym: "nucleoside:proton symporter activity" EXACT []
is_a: GO:0005337 ! nucleoside transmembrane transporter activity
is_a: GO:0015295 ! solute:hydrogen symporter activity

[Term]
id: GO:0015507
name: hydroxy/aromatic amino acid permease activity
namespace: molecular_function
def: "OBSOLETE. Permease for hydroxy and aromatic amino acids." [GOC:ai]
comment: This term was made obsolete because it is a redundant grouping term.
is_obsolete: true
consider: GO:0015171
consider: GO:0015173

[Term]
id: GO:0015513
name: nitrite uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of nitrite from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "nitrite uptake permease activity" EXACT []
is_a: GO:0015113 ! nitrite transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0015563 ! uptake transmembrane transporter activity

[Term]
id: GO:0015514
name: nitrite efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "nitrite extrusion permease activity" EXACT []
is_a: GO:0015113 ! nitrite transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0015515
name: citrate:succinate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out)." [TC:2.A.47.3.2]
subset: gosubset_prok
is_a: GO:0015137 ! citrate transmembrane transporter activity
is_a: GO:0015141 ! succinate transmembrane transporter activity
is_a: GO:0015301 ! anion:anion antiporter activity

[Term]
id: GO:0015516
name: tartrate:succinate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out)." [TC:2.A.47.3.3]
is_a: GO:0015141 ! succinate transmembrane transporter activity
is_a: GO:0015301 ! anion:anion antiporter activity
is_a: GO:0015554 ! tartrate transmembrane transporter activity

[Term]
id: GO:0015517
name: galactose:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in)." [TC:2.A.1.1.1, TC:2.A.1.1.9]
subset: gosubset_prok
synonym: "galactose:proton symporter activity" EXACT []
synonym: "lactose, galactose:hydrogen symporter activity" BROAD []
is_a: GO:0005354 ! galactose transmembrane transporter activity
is_a: GO:0009679 ! hexose:hydrogen symporter activity

[Term]
id: GO:0015518
name: arabinose:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in)." [TC:2.A.1.1.2]
synonym: "arabinose:proton symporter activity" EXACT []
is_a: GO:0005351 ! sugar:hydrogen symporter activity
is_a: GO:0042900 ! arabinose transmembrane transporter activity

[Term]
id: GO:0015519
name: D-xylose:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in)." [TC:2.A.1.1.3]
subset: gosubset_prok
synonym: "D-xylose:proton symporter activity" EXACT []
is_a: GO:0005351 ! sugar:hydrogen symporter activity
is_a: GO:0015148 ! D-xylose transmembrane transporter activity

[Term]
id: GO:0015520
name: tetracycline:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out)." [TC:2.A.1.2.4]
subset: gosubset_prok
synonym: "tetracyclin:hydrogen antiporter activity" EXACT []
synonym: "tetracyclin:proton antiporter activity" EXACT []
synonym: "tetracycline:proton antiporter activity" EXACT []
is_a: GO:0008493 ! tetracycline transporter activity
is_a: GO:0015307 ! drug:hydrogen antiporter activity

[Term]
id: GO:0015521
name: bicyclomycin/sulfathiazole:hydrogen antiporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (bicyclomycin or sulfathiazole)(in) + H+(out) = (bicyclomycin or sulfathiazole)(out) + H+(in)." [TC:2.A.1.2.7]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "bicyclomycin/sulfathiazole:proton antiporter activity" EXACT []
synonym: "bicyclomycin/sulphathiazole:hydrogen antiporter activity" EXACT []
is_obsolete: true
consider: GO:0015545
consider: GO:0015546
consider: GO:0045119

[Term]
id: GO:0015522
name: hydrophobic uncoupler:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hydrophobic uncoupler(in) + H+(out) = hydrophobic uncoupler(out) + H+(in). Hydrophobic uncouplers include CCCP, benzalkonium and SDS." [TC:2.A.1.2.9]
synonym: "hydrophobic uncoupler:proton antiporter activity" EXACT []
is_a: GO:0015307 ! drug:hydrogen antiporter activity
is_a: GO:0017077 ! oxidative phosphorylation uncoupler activity

[Term]
id: GO:0015523
name: arabinose efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of arabinose from the inside of the cell to the outside of the cell across a membrane: H+(out) + arabinose(in) = H+(in) + arabinose(out)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.1.2.14]
synonym: "arabinose efflux permease activity" EXACT []
is_a: GO:0005351 ! sugar:hydrogen symporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity
is_a: GO:0042900 ! arabinose transmembrane transporter activity

[Term]
id: GO:0015524
name: L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H+(out) + (L-arabinose or beta-D-thiogalactopyranoside)(in) = H+(in) + (L-arabinose or beta-D-thiogalactopyranoside)(out)." [TC:2.A.1.2.15]
comment: This term was made obsolete because it represents a gene product rather than a single discrete molecular function.
synonym: "L-arabinose/beta-D-thiogalactopyranoside:proton antiporter activity" EXACT []
is_obsolete: true
consider: GO:0015147
consider: GO:0015299
consider: GO:0051119

[Term]
id: GO:0015525
name: carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:proton antiporter activity" EXACT []
is_obsolete: true
replaced_by: GO:0015307
replaced_by: GO:0015547
replaced_by: GO:0015548
replaced_by: GO:0015549

[Term]
id: GO:0015526
name: hexose-phosphate:inorganic phosphate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + inorganic phosphate(in) = hexose phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.1]
is_a: GO:0005351 ! sugar:hydrogen symporter activity
is_a: GO:0015119 ! hexose phosphate transmembrane transporter activity
is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity

[Term]
id: GO:0015527
name: glycerol-phosphate:inorganic phosphate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.3]
is_a: GO:0005351 ! sugar:hydrogen symporter activity
is_a: GO:0015169 ! glycerol-3-phosphate transmembrane transporter activity
is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity

[Term]
id: GO:0015528
name: lactose:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in)." [TC:2.A.1.1.9, TC:2.A.1.5.1]
synonym: "lactose, galactose:hydrogen symporter activity" BROAD []
synonym: "lactose:proton symporter activity" EXACT []
is_a: GO:0005351 ! sugar:hydrogen symporter activity
is_a: GO:0015155 ! lactose transmembrane transporter activity

[Term]
id: GO:0015529
name: raffinose:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in)." [TC:2.A.1.5.2]
synonym: "raffinose:proton symporter activity" EXACT []
is_a: GO:0005351 ! sugar:hydrogen symporter activity
is_a: GO:0015158 ! raffinose transmembrane transporter activity

[Term]
id: GO:0015530
name: shikimate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of shikimate from one side of the membrane to the other. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015531
name: citrate:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in)." [TC:2.A.1.6.1]
synonym: "citrate:proton symporter activity" EXACT []
is_a: GO:0015137 ! citrate transmembrane transporter activity
is_a: GO:0015295 ! solute:hydrogen symporter activity

[Term]
id: GO:0015532
name: alpha-ketoglutarate:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in)." [TC:2.A.1.6.2]
subset: gosubset_prok
synonym: "2-oxoglutarate:hydrogen symporter activity" EXACT []
synonym: "2-oxoglutarate:proton symporter activity" EXACT []
synonym: "alpha-ketoglutarate:proton symporter activity" EXACT []
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015139 ! alpha-ketoglutarate transmembrane transporter activity
is_a: GO:0015295 ! solute:hydrogen symporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015533
name: shikimate:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in)." [TC:2.A.1.6.6]
synonym: "shikimate:proton symporter activity" EXACT []
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015295 ! solute:hydrogen symporter activity
is_a: GO:0015296 ! anion:cation symporter activity
is_a: GO:0015530 ! shikimate transmembrane transporter activity

[Term]
id: GO:0015534
name: proline/glycine/betaine:hydrogen/sodium symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (proline, glycine or betaine)(out) + (H+ or Na+)(out) = (proline, glycine or betaine)(in) + (H+ or Na+)(in)." [TC:2.A.1.6.4]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "proline/glycine/betaine:proton/sodium symporter" EXACT []
is_obsolete: true
consider: GO:0015187
consider: GO:0015193
consider: GO:0015199
consider: GO:0015294
consider: GO:0015295
consider: GO:0015370

[Term]
id: GO:0015535
name: fucose:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in)." [TC:2.A.1.7.1]
synonym: "fucose:proton symporter activity" EXACT []
is_a: GO:0009679 ! hexose:hydrogen symporter activity
is_a: GO:0015150 ! fucose transmembrane transporter activity

[Term]
id: GO:0015537
name: xanthosine:hydrogen ion symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in)." [TC:2.A.1.10.2]
synonym: "xanthosine permease activity" RELATED []
is_a: GO:0015506 ! nucleoside:hydrogen symporter activity
is_a: GO:0015553 ! xanthosine transmembrane transporter activity

[Term]
id: GO:0015538
name: sialic acid:hydrogen ion symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in)." [TC:2.A.1.12.1]
subset: gosubset_prok
synonym: "sialic acid permease activity" RELATED []
is_a: GO:0005351 ! sugar:hydrogen symporter activity
is_a: GO:0015136 ! sialic acid transmembrane transporter activity

[Term]
id: GO:0015539
name: hexuronate:cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexuronate(out) + cation(out) = hexuronate(in) + cation(in). The hexuronate may be glucuronate or galacturonate." [TC:2.A.1.14.2]
synonym: "hexuronate (glucuronate/galacturonate) porter activity" NARROW []
synonym: "hexuronate porter activity" RELATED []
is_a: GO:0005351 ! sugar:hydrogen symporter activity
is_a: GO:0015134 ! hexuronate transmembrane transporter activity

[Term]
id: GO:0015540
name: 3-hydroxyphenyl propionate:hydrogen ion symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in)." [TC:2.A.1.15.2]
synonym: "3-hydroxyphenyl propionate porter activity" RELATED []
is_a: GO:0015293 ! symporter activity
is_a: GO:0015551 ! 3-hydroxyphenyl propanoate transmembrane transporter activity

[Term]
id: GO:0015541
name: secondary active cyanate uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cyanate(out) = cyanate(in)." [TC:2.A.1.17.1]
synonym: "cyanate porter activity" RELATED []
is_a: GO:0015110 ! cyanate transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015542
name: sugar efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(in) = sugar(out)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.1.20.1]
subset: gosubset_prok
synonym: "lactose/glucose efflux transporter activity" NARROW []
is_a: GO:0005351 ! sugar:hydrogen symporter activity

[Term]
id: GO:0015543
name: lactose/glucose efflux transporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: glucose or lactose(in) = glucose or lactose(out)." [TC:2.A.1.20.2]
comment: This term was made obsolete because it represents two molecular functions.
is_obsolete: true
consider: GO:0005355
consider: GO:0015155
consider: GO:0015542

[Term]
id: GO:0015544
name: phenyl propionate uptake uniporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenyl propionate(out) = phenyl propionate(in)." [GOC:mtg_transport, TC:2.A.1.27.1]
synonym: "phenyl propionate permease activity" RELATED []
is_a: GO:0015291 ! secondary active transmembrane transporter activity
is_a: GO:0015552 ! propionate transmembrane transporter activity

[Term]
id: GO:0015545
name: bicyclomycin transporter activity
namespace: molecular_function
def: "Enables the directed movement of bicyclomycin into, out of, within or between cells. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [ISBN:91191028X]
subset: gosubset_prok
synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" NARROW []
is_a: GO:0042895 ! antibiotic transporter activity

[Term]
id: GO:0015546
name: sulfathiazole transporter activity
namespace: molecular_function
def: "Enables the directed movement of sulfathiazole into, out of, within or between cells. Sulfathiazole is an antibacterial agent of the sulfonamide group." [http://cancerweb.ncl.ac.uk/]
synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" NARROW []
synonym: "sulphathiazole transporter activity" EXACT []
is_a: GO:0045118 ! azole transporter activity

[Term]
id: GO:0015547
name: nalidixic acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of nalidixic acid into, out of, within or between cells. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [http://cancerweb.ncl.ac.uk/]
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW []
is_a: GO:0042895 ! antibiotic transporter activity
is_a: GO:0042910 ! xenobiotic transporter activity

[Term]
id: GO:0015548
name: organomercurial transporter activity
namespace: molecular_function
def: "Enables the directed movement of organomercurial compounds into, out of, within or between cells. Organomercurial substances are any organic compound containing a mercury atom." [GOC:ai]
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW []
is_a: GO:0015238 ! drug transmembrane transporter activity

[Term]
id: GO:0015549
name: carbonyl cyanide m-chlorophenylhydrazone transporter activity
namespace: molecular_function
def: "Enables the directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of, within or between cells. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [http://cancerweb.ncl.ac.uk/]
synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW []
synonym: "CCCP transporter activity" EXACT []
is_a: GO:0015238 ! drug transmembrane transporter activity

[Term]
id: GO:0015550
name: galacturonate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of galacturonate from one side of the membrane to the other. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai]
is_a: GO:0015134 ! hexuronate transmembrane transporter activity

[Term]
id: GO:0015551
name: 3-hydroxyphenyl propanoate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of 3-hydroxyphenyl propanoate from one side of the membrane to the other." [GOC:ai]
synonym: "3-hydroxyphenyl propionate transmembrane transporter activity" EXACT []
is_a: GO:0015552 ! propionate transmembrane transporter activity

[Term]
id: GO:0015552
name: propionate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of propionate from one side of the membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH." [GOC:ai]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015553
name: xanthosine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity

[Term]
id: GO:0015554
name: tartrate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of tartrate from one side of the membrane to the other. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0042876 ! aldarate transmembrane transporter activity

[Term]
id: GO:0015555
name: acriflavine resistant pump activity
namespace: molecular_function
synonym: "acriflavin resistant pump activity" RELATED [GOC:dph, GOC:tb]
is_a: GO:0015566 ! acriflavine transporter activity

[Term]
id: GO:0015556
name: C4-dicarboxylate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of C4-dicarboxylate from one side of the membrane to the other." [GOC:krc]
subset: gosubset_prok
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity

[Term]
id: GO:0015557
name: arginine targeting transmembrane transporter activity
namespace: molecular_function
is_a: GO:0008565 ! protein transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0015558
name: p-aminobenzoyl-glutamate uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of p-aminobenzoyl-glutamate from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "p-aminobenzoyl-glutamate uptake permease activity" EXACT []
is_a: GO:0015563 ! uptake transmembrane transporter activity
is_a: GO:0015569 ! p-aminobenzoyl-glutamate transmembrane transporter activity

[Term]
id: GO:0015559
name: multidrug efflux pump activity
namespace: molecular_function
subset: gosubset_prok
is_a: GO:0015239 ! multidrug transporter activity

[Term]
id: GO:0015560
name: L-idonate/D-gluconate:hydrogen symporter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: (L-idonate or D-gluconate)(out) + H+(out) = (L-iodonate or D-gluconate)(in) + H+(in)." [TC:2.A.8.1.2]
comment: This term was made obsolete because it represents a multifunctional gene product.
synonym: "L-idonate/D-gluconate:proton symporter" EXACT []
is_obsolete: true
consider: GO:0015128
consider: GO:0015295
consider: GO:0015568

[Term]
id: GO:0015561
name: rhamnose:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in)." [TC:2.A.7.6.1]
synonym: "rhamnose:proton symporter activity" EXACT []
is_a: GO:0009679 ! hexose:hydrogen symporter activity
is_a: GO:0015153 ! rhamnose transmembrane transporter activity

[Term]
id: GO:0015562
name: efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "efflux permease activity" EXACT []
synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" NARROW []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015563
name: uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a specific substance or related group of substances from the outside of a cell to the inside across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "cobalt, zinc uptake permease activity" NARROW []
synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" NARROW []
synonym: "uptake permease activity" RELATED []
synonym: "zinc, cadmium uptake permease activity" NARROW []
synonym: "zinc, iron permease activity" NARROW []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0015564
name: multidrug, alkane resistant pump activity
namespace: molecular_function
is_a: GO:0015239 ! multidrug transporter activity
is_a: GO:0015567 ! alkane transporter activity

[Term]
id: GO:0015565
name: threonine efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of threonine from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "threonine efflux permease activity" EXACT []
synonym: "threonine export protein" RELATED []
synonym: "threonine export transporter activity" EXACT []
is_a: GO:0015195 ! L-threonine transmembrane transporter activity
is_a: GO:0034639 ! L-amino acid efflux transmembrane transporter activity

[Term]
id: GO:0015566
name: acriflavine transporter activity
namespace: molecular_function
def: "Enables the directed movement of acriflavin into, out of, within or between cells. Acriflavin is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [http://cancerweb.ncl.ac.uk/]
synonym: "acriflavin transporter activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015238 ! drug transmembrane transporter activity
is_a: GO:0042910 ! xenobiotic transporter activity

[Term]
id: GO:0015567
name: alkane transporter activity
namespace: molecular_function
def: "Enables the directed movement of alkanes into, out of, within or between cells. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai]
is_a: GO:0015238 ! drug transmembrane transporter activity

[Term]
id: GO:0015568
name: L-idonate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-idonate from one side of the membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:ai]
subset: gosubset_prok
synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0042879 ! aldonate transmembrane transporter activity

[Term]
id: GO:0015569
name: p-aminobenzoyl-glutamate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid." [GOC:ai]
subset: gosubset_prok
synonym: "p-aminobenzoyl-glutamate transporter activity" BROAD []
is_a: GO:0015171 ! amino acid transmembrane transporter activity

[Term]
id: GO:0015570
name: energizer of outer membrane receptor-mediated transport activity
namespace: molecular_function
is_a: GO:0015404 ! ion-gradient-driven energizer activity

[Term]
id: GO:0015571
name: N-acetylgalactosamine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015590
def: "Catalysis of the transfer of N-acetylgalactosamine from one side of the membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "N-acetylgalactosamine permease activity" EXACT []
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0015572
name: N-acetylglucosamine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015580
def: "Catalysis of the transfer of N-acetylglucosamine from one side of the membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "D-GlcNAc transmembrane transporter activity" EXACT []
synonym: "N-Acetyl-D-glucosamine permease" RELATED []
synonym: "N-acetyl-D-glucosamine transmembrane transporter activity" EXACT []
synonym: "N-acetylchitosamine transmembrane transporter activity" EXACT []
synonym: "N-acetylglucosamine permease activity" RELATED []
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0015573
name: beta-glucoside transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015582
def: "Catalysis of the transfer of beta-glucosides from one side of the membrane to the other. Beta-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
synonym: "beta-glucoside permease activity" EXACT []
is_a: GO:0042947 ! glucoside transmembrane transporter activity

[Term]
id: GO:0015574
name: trehalose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015584
def: "Catalysis of the transfer of trehalose from one side of the membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
synonym: "trehalose permease activity" EXACT []
is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity
is_a: GO:0015154 ! disaccharide transmembrane transporter activity

[Term]
id: GO:0015575
name: mannitol transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015586
def: "Catalysis of the transfer of mannitol from one side of the membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "mannitol permease activity" EXACT []
is_a: GO:0015166 ! polyol transmembrane transporter activity

[Term]
id: GO:0015576
name: sorbitol transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015587
def: "Catalysis of the transfer of sorbitol from one side of the membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glucitol permease activity" EXACT []
synonym: "glucitol transporter activity" EXACT []
synonym: "sorbitol permease activity" EXACT []
is_a: GO:0015166 ! polyol transmembrane transporter activity

[Term]
id: GO:0015577
name: galactitol transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015588
def: "Catalysis of the transfer of a galactitol from one side of the membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "galactitol permease activity" EXACT []
is_a: GO:0015166 ! polyol transmembrane transporter activity

[Term]
id: GO:0015578
name: mannose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015589
def: "Catalysis of the transfer of mannose from one side of the membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "mannose permease activity" EXACT []
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0015583
name: beta-glucoside [arbutin-salicin-cellobiose] permease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). The beta-glucoside may be arbutin, salicin or cellobiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because it arbitrarily groups three substrates.
is_obsolete: true

[Term]
id: GO:0015591
name: D-ribose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of D-ribose from one side of the membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015146 ! pentose transmembrane transporter activity

[Term]
id: GO:0015592
name: methylgalactoside transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of methylgalactoside from one side of the membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [GOC:mtg_transport, http://cancerweb.ncl.ac.uk/, ISBN:0815340729]
subset: gosubset_prok
synonym: "galactose/glucose (methylgalactoside) porter activity" NARROW []
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0015593
name: allose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of allose from one side of the membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0015594
name: putrescine-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + putrescine(out) = ADP + phosphate + putrescine(in)." [EC:3.6.3.31]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "putrescine porter activity" BROAD []
is_a: GO:0015417 ! polyamine-transporting ATPase activity
is_a: GO:0015489 ! putrescine transmembrane transporter activity

[Term]
id: GO:0015595
name: spermidine-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + spermidine(out) = ADP + phosphate + spermidine(in)." [EC:3.6.3.31]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "spermidine porter activity" BROAD []
is_a: GO:0015417 ! polyamine-transporting ATPase activity
is_a: GO:0015606 ! spermidine transmembrane transporter activity

[Term]
id: GO:0015596
name: glycine betaine/proline porter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in)." [EC:3.6.3.32, TC:3.A.1.12.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0015187
consider: GO:0015193
consider: GO:0015199
consider: GO:0015418

[Term]
id: GO:0015597
name: histidine/arginine/lysine/ornithine porter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0000064
consider: GO:0005290
consider: GO:0015181
consider: GO:0015189
consider: GO:0015426

[Term]
id: GO:0015598
name: arginine-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arginine(out) = ADP + phosphate + arginine(in)." [EC:3.6.3.21]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "arginine porter activity" EXACT []
is_a: GO:0015181 ! arginine transmembrane transporter activity
is_a: GO:0015426 ! polar-amino acid-transporting ATPase activity

[Term]
id: GO:0015599
name: glutamine-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) = ADP + phosphate + glutamine(in)." [EC:3.6.3.21]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "glutamine porter activity" BROAD []
is_a: GO:0015186 ! L-glutamine transmembrane transporter activity
is_a: GO:0015426 ! polar-amino acid-transporting ATPase activity

[Term]
id: GO:0015600
name: glutamate/aspartate porter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.4]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0005313
consider: GO:0015183
consider: GO:0015426

[Term]
id: GO:0015601
name: cystine/diaminopimelate porter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.10]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0015184
consider: GO:0015426
consider: GO:0015626

[Term]
id: GO:0015602
name: leucine/isoleucine/valine porter activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:3.6.3.22, TC:3.A.1.4.1]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0005304
consider: GO:0015188
consider: GO:0015190
consider: GO:0015425

[Term]
id: GO:0015603
name: iron chelate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of an iron chelate from one side of a membrane to the other. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [http://www.onelook.com]
subset: gosubset_prok
is_a: GO:0005381 ! iron ion transmembrane transporter activity

[Term]
id: GO:0015604
name: phosphonate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of phosphonate from one side of a membrane to the other. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008514 ! organic anion transmembrane transporter activity

[Term]
id: GO:0015605
name: organophosphate ester transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc]
is_a: GO:0008514 ! organic anion transmembrane transporter activity

[Term]
id: GO:0015606
name: spermidine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of the membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015203 ! polyamine transmembrane transporter activity

[Term]
id: GO:0015607
name: fatty acyl CoA transporter activity
namespace: molecular_function
def: "Enables the directed movement of a fatty acyl CoA group into, out of, within or between cells. A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A moiety attached to it." [GOC:ai]
is_a: GO:0015246 ! fatty acyl transporter activity

[Term]
id: GO:0015608
name: carbohydrate-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) = ADP + phosphate + carbohydrate(in)." [GOC:ai, TC:3.A.1.1.-, TC:3.A.1.2.-]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "carbohydrate uptake transporter activity" EXACT []
synonym: "sugar transporter" NARROW []
is_a: GO:0043211 ! carbohydrate-transporting ATPase activity

[Term]
id: GO:0015609
name: maltooligosaccharide-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltooligosaccharide(out) = ADP + phosphate + maltooligosaccharide(in)." [TC:3.A.1.-.-]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "maltooligosaccharide porter activity" BROAD []
is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity
is_a: GO:0015608 ! carbohydrate-importing ATPase activity

[Term]
id: GO:0015610
name: glycerol phosphate-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-phosphate(out) = ADP + phosphate + glycerol-phosphate(in)." [TC:3.A.1.-.-]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "glycerol-phosphate porter activity" BROAD []
is_a: GO:0015169 ! glycerol-3-phosphate transmembrane transporter activity
is_a: GO:0015608 ! carbohydrate-importing ATPase activity

[Term]
id: GO:0015611
name: D-ribose-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) = ADP + phosphate + D-ribose(in)." [TC:3.A.1.-.-]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "D-ribose porter activity" BROAD []
is_a: GO:0015407 ! monosaccharide-transporting ATPase activity
is_a: GO:0015591 ! D-ribose transmembrane transporter activity

[Term]
id: GO:0015612
name: L-arabinose-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) = ADP + phosphate + L-arabinose(in)." [TC:3.A.1.-.-]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "L-arabinose porter activity" EXACT []
is_a: GO:0015147 ! L-arabinose transmembrane transporter activity
is_a: GO:0015407 ! monosaccharide-transporting ATPase activity

[Term]
id: GO:0015613
name: galactose/glucose (methylgalactoside) porter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a multifunctional gene product.
is_obsolete: true
consider: GO:0005354
consider: GO:0005355
consider: GO:0015291
consider: GO:0015592

[Term]
id: GO:0015614
name: D-xylose-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) = ADP + phosphate + D-xylose(in)." [TC:3.A.1.-.-]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "D-xylose porter activity" BROAD []
is_a: GO:0015148 ! D-xylose transmembrane transporter activity
is_a: GO:0015407 ! monosaccharide-transporting ATPase activity

[Term]
id: GO:0015615
name: D-allose-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-allose(out) = ADP + phosphate + D-allose(in)." [TC:3.A.1.-.-]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "D-allose porter activity" BROAD []
is_a: GO:0015593 ! allose transmembrane transporter activity
is_a: GO:0015608 ! carbohydrate-importing ATPase activity

[Term]
id: GO:0015616
name: DNA translocase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive movement along a single- or double-stranded DNA molecule." [GOC:mah, PMID:16428451, PMID:17631491]
comment: Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane.
is_a: GO:0003677 ! DNA binding
is_a: GO:0008094 ! DNA-dependent ATPase activity

[Term]
id: GO:0015617
name: pilin/fimbrilin exporter activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0015462

[Term]
id: GO:0015619
name: thiamin pyrophosphate-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiamin pyrophosphate(out) = ADP + phosphate + thiamin pyrophosphate(in)." [TC:3.A.1.19.1]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "thiamin pyrophosphate ABC transporter" NARROW []
synonym: "thiamin pyrophosphate porter activity" BROAD []
synonym: "thiamine pyrophosphate transporting ATPase activity" EXACT []
synonym: "TPP transporting ATPase activity" EXACT []
is_a: GO:0015234 ! thiamin transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015620
name: ferric-enterobactin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of ferric-enterobactin from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity

[Term]
id: GO:0015621
name: ferric triacetylfusarinine C transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of ferric triacetylfusarinine C from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015091 ! ferric iron transmembrane transporter activity

[Term]
id: GO:0015622
name: ferric-hydroxamate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of ferric-hydroxamate from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity

[Term]
id: GO:0015623
name: iron-chelate-transporting ATPase activity
namespace: molecular_function
alt_id: GO:0015409
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + iron chelate(out) = ADP + phosphate + iron chelate(in). Fe-enterobactin, Fe-dicitrate, Fe-hydroxamate and other siderophores are imported." [EC:3.6.3.34]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (iron-chelate-importing)" EXACT [EC:3.6.3.34]
synonym: "ferric/ferric-dicitrate porter" BROAD []
synonym: "iron-chelate ABC transporter" NARROW []
xref: EC:3.6.3.34
xref: MetaCyc:3.6.3.34-RXN
is_a: GO:0015603 ! iron chelate transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0015624
name: ferric-enterobactin-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in)." [TC:3.A.1.-.-]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ferric-enterobactin ABC transporter" NARROW []
synonym: "ferric-enterobactin porter activity" BROAD []
is_a: GO:0015620 ! ferric-enterobactin transmembrane transporter activity
is_a: GO:0015623 ! iron-chelate-transporting ATPase activity

[Term]
id: GO:0015625
name: ferric-hydroxamate-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in)." [TC:3.A.1.-.-]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ferric-hydroxamate ABC transporter" NARROW []
synonym: "ferric-hydroxamate porter activity" BROAD []
is_a: GO:0015622 ! ferric-hydroxamate transmembrane transporter activity
is_a: GO:0015623 ! iron-chelate-transporting ATPase activity

[Term]
id: GO:0015626
name: L-diaminopimelate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
synonym: "cystine/diaminopimelate porter activity" NARROW []
synonym: "L-diaminopimelate transporter activity" BROAD []
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0015627
name: type II protein secretion system complex
namespace: cellular_component
def: "A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex." [PMID:16448494]
comment: Note that the type II protein secretion system complex does not include components of the Sec or Tat pathways. For components of these pathways, consider annotating to 'cell envelope Sec complex ; GO:0031522' or 'TAT protein translocation system complex ; GO:0033281'.
subset: gosubset_prok
synonym: "general secretion pathway-associated complex" RELATED []
synonym: "main terminal branch" EXACT []
synonym: "MTB" EXACT []
synonym: "Sec-dependent secretion system-associated complex" RELATED []
synonym: "T2SS-associated complexes" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0015628
name: protein secretion by the type II secretion system
namespace: biological_process
def: "The process by which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type II protein secretion system complex ; GO:0015627'. This process refers specifically to secretion across the outer membrane. For components of the Sec and Tat pathways, consider annotating to 'protein transport by the Sec complex ; GO:0043952' and 'protein transport by the Tat complex ; GO:0043953'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted.
subset: gosubset_prok
synonym: "protein secretion by the general secretion pathway" RELATED []
synonym: "protein secretion by the general secretory pathway" RELATED []
synonym: "protein secretion by the T2S" EXACT []
synonym: "protein secretion by the T2SS" EXACT []
synonym: "protein secretion by the type II protein secretion system" EXACT []
synonym: "type II protein secretion system" EXACT []
is_a: GO:0009306 ! protein secretion

[Term]
id: GO:0015629
name: actin cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, http://cancerweb.ncl.ac.uk/, ISBN:0395825172]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0015630
name: microtubule cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0015631
name: tubulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0015633
name: zinc transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in)." [TC:3.A.1.-.-]
synonym: "zinc porter activity" RELATED []
is_a: GO:0005385 ! zinc ion transmembrane transporter activity

[Term]
id: GO:0015634
name: lipopolysaccharide exporter activity
namespace: molecular_function
def: "Catalysis of the transfer of lipopolysaccharide from the inside of the cell to the outside of the cell across a membrane. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:mtg_transport, ISBN:0815340729]
synonym: "LPS exporter activity" EXACT []
is_a: GO:0015221 ! lipopolysaccharide transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0015635
name: short-chain fatty acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of short-chain fatty acids into, out of, within or between cells. Short-chain fatty acids have a chain length of less than 8 carbons." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015245 ! fatty acid transporter activity

[Term]
id: GO:0015636
name: short-chain fatty acid uptake transporter activity
namespace: molecular_function
is_a: GO:0015635 ! short-chain fatty acid transporter activity

[Term]
id: GO:0015638
name: microcin uptake permease activity
namespace: molecular_function
subset: gosubset_prok
is_a: GO:0015197 ! peptide transporter activity
is_a: GO:0015238 ! drug transmembrane transporter activity

[Term]
id: GO:0015639
name: ferrous iron uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) + energy = Fe2+(in)." [TC:9.A.8.1.1]
subset: gosubset_prok
is_a: GO:0015093 ! ferrous iron transmembrane transporter activity

[Term]
id: GO:0015640
name: peptidoglycan peptide transporter activity
namespace: molecular_function
def: "Enables the directed movement of peptidoglycan peptides into, out of, within or between cells. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "murein peptide transporter activity" EXACT []
synonym: "muropeptide transporter activity" EXACT []
is_a: GO:0015197 ! peptide transporter activity
is_a: GO:0015647 ! peptidoglycan transporter activity

[Term]
id: GO:0015641
name: lipoprotein toxin
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0009405
replaced_by: GO:0050827

[Term]
id: GO:0015642
name: bacteriolytic toxin activity
namespace: molecular_function
def: "OBSOLETE. Acts as to cause lysis of bacterial cells." [GOC:jl, http://cancerweb.ncl.ac.uk/]
comment: This term was made obsolete because it represents a class of gene products and not a molecular function.
is_obsolete: true
consider: GO:0019835

[Term]
id: GO:0015643
name: toxin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a toxin, a poisonous substance that causes damage to biological systems. Toxins are differentiated from simple chemical poisons and vegetable alkaloids by their high molecular weight and antigenicity (they elicit an antibody response)." [GOC:ai, http://cancerweb.ncl.ac.uk/]
synonym: "antitoxin activity" RELATED []
synonym: "lipoprotein antitoxin" RELATED []
is_a: GO:0005488 ! binding

[Term]
id: GO:0015644
name: lipoprotein antitoxin
namespace: molecular_function
def: "OBSOLETE. Binds to a lipoprotein toxin, which is usually derived from a microorganism, thereby neutralizing it." [GOC:jl]
comment: This term was made obsolete because it does not represent a function distinct from its parent term.
is_obsolete: true
replaced_by: GO:0015643

[Term]
id: GO:0015645
name: fatty-acid ligase activity
namespace: molecular_function
def: "Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP." [EC:6.2.1.20, EC:6.2.1.3, GOC:cjk, GOC:mah]
subset: gosubset_prok
synonym: "acid:CoA ligase (AMP-forming) activity" EXACT [EC:6.2.1.3]
synonym: "acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3]
synonym: "acyl-coenzyme A ligase activity" EXACT [EC:6.2.1.3]
synonym: "fatty acid CoA ligase activity" EXACT [EC:6.2.1.3]
synonym: "fatty acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3]
xref: EC:6.2.1.-
is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds

[Term]
id: GO:0015647
name: peptidoglycan transporter activity
namespace: molecular_function
def: "Enables the directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of, within or between cells." [GOC:ai]
subset: gosubset_prok
synonym: "murein transporter activity" EXACT []
is_a: GO:0022892 ! substrate-specific transporter activity

[Term]
id: GO:0015648
name: lipid-linked peptidoglycan transporter activity
namespace: molecular_function
synonym: "lipid-linked murein transporter activity" EXACT []
is_a: GO:0015647 ! peptidoglycan transporter activity

[Term]
id: GO:0015649
name: 2-keto-3-deoxygluconate:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in)." [TC:2.A.10.1.1]
subset: gosubset_prok
synonym: "2-keto-3-deoxygluconate:proton symporter activity" EXACT []
is_a: GO:0005402 ! cation:sugar symporter activity
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015128 ! gluconate transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015650
name: lactate:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in)." [TC:2.A.14.1.1]
synonym: "lactate permease" BROAD []
synonym: "lactate:hydrogen porter activity" EXACT []
synonym: "lactate:proton porter activity" EXACT []
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0015651
name: quaternary ammonium group transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015202
def: "Catalysis of the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "quaternary amine transmembrane transporter activity" EXACT []
synonym: "quaternary ammonium compound transporter activity" EXACT []
is_a: GO:0005275 ! amine transmembrane transporter activity
is_a: GO:0015101 ! organic cation transmembrane transporter activity
is_a: GO:0022890 ! inorganic cation transmembrane transporter activity

[Term]
id: GO:0015652
name: quaternary ammonium group:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in)." [GOC:ai]
subset: gosubset_prok
synonym: "quaternary ammonium group:proton symporter activity" EXACT []
is_a: GO:0015295 ! solute:hydrogen symporter activity
is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity

[Term]
id: GO:0015653
name: glycine betaine:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in)." [TC:2.A.15.1.1]
subset: gosubset_prok
synonym: "glycine betaine:proton symporter activity" EXACT []
is_a: GO:0015652 ! quaternary ammonium group:hydrogen symporter activity

[Term]
id: GO:0015654
name: tellurite uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of tellurite from the outside of a cell to the inside across a membrane: tellurite(out) + H+(out) = tellurite(in) + H+(in)." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.16.1.1]
synonym: "tellurite-resistance uptake permease activity" EXACT []
synonym: "tellurite-resistance uptake transmembrane transporter activity" EXACT []
is_a: GO:0015563 ! uptake transmembrane transporter activity

[Term]
id: GO:0015655
name: alanine:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005283 ! sodium:amino acid symporter activity
is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity

[Term]
id: GO:0015657
name: branched-chain amino acid:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in)." [TC:2.A.26.1.1]
is_a: GO:0005283 ! sodium:amino acid symporter activity
is_a: GO:0015658 ! branched-chain aliphatic amino acid transmembrane transporter activity

[Term]
id: GO:0015658
name: branched-chain aliphatic amino acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of branched-chain aliphatic amino acids from one side of a membrane to the other. Branched-chain aliphatic amino acids are amino acids with a branched carbon skeleton without rings." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "branched-chain aliphatic amino acid transporter activity" BROAD []
synonym: "leucine/valine/isoleucine permease activity" RELATED []
synonym: "valine/tyrosine/tryptophan permease activity" RELATED []
is_a: GO:0015171 ! amino acid transmembrane transporter activity

[Term]
id: GO:0015659
name: formate uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of formate from the outside of a cell to the inside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "formate uptake permease activity" EXACT []
is_a: GO:0015499 ! formate transmembrane transporter activity
is_a: GO:0015563 ! uptake transmembrane transporter activity

[Term]
id: GO:0015660
name: formate efflux transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015509
def: "Catalysis of the transfer of formate from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "formate efflux permease activity" EXACT []
is_a: GO:0015499 ! formate transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0015661
name: L-lysine efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "L-lysine exporter activity" EXACT []
synonym: "L-lysine, 2,6-diaminohexanoic acid efflux transmembrane transporter activity" EXACT []
is_a: GO:0015189 ! L-lysine transmembrane transporter activity
is_a: GO:0034639 ! L-amino acid efflux transmembrane transporter activity

[Term]
id: GO:0015662
name: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "P-type ATPase activity" EXACT []
synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW []
is_a: GO:0042625 ! ATPase activity, coupled to transmembrane movement of ions

[Term]
id: GO:0015663
name: nicotinamide mononucleotide transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015664
def: "Enables the directed movement of nicotinamide mononucleotide into, out of, within or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "nicotinamide mononucleotide permease activity" RELATED []
synonym: "nicotinamide ribonucleotide transmembrane transporter activity" EXACT []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:0051184 ! cofactor transporter activity

[Term]
id: GO:0015665
name: alcohol transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of an alcohol from one side of the membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0015666
name: restriction endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mlg]
subset: gosubset_prok
synonym: "restriction endonuclease activity" EXACT []
synonym: "restriction enzyme activity" EXACT []
is_a: GO:0004520 ! endodeoxyribonuclease activity

[Term]
id: GO:0015667
name: site-specific DNA-methyltransferase (cytosine-N4-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine." [EC:2.1.1.113]
subset: gosubset_prok
synonym: "DNA[cytosine-N4]methyltransferase activity" EXACT [EC:2.1.1.113]
synonym: "m4C-forming MTase activity" EXACT [EC:2.1.1.113]
synonym: "modification methylase activity" RELATED [EC:2.1.1.113]
synonym: "N(4)-cytosine-specific DNA methylase activity" EXACT [EC:2.1.1.113]
synonym: "N4-cytosine-specific DNA methylase activity" EXACT [EC:2.1.1.113]
synonym: "restriction-modification system activity" RELATED [EC:2.1.1.113]
synonym: "S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase activity" EXACT [EC:2.1.1.113]
synonym: "S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase activity" EXACT [EC:2.1.1.113]
xref: EC:2.1.1.113
xref: MetaCyc:2.1.1.113-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0009008 ! DNA-methyltransferase activity

[Term]
id: GO:0015668
name: Type III site-specific deoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites." [EC:3.1.21.5, PMID:12654995]
subset: gosubset_prok
synonym: "Type III restriction enzyme activity" EXACT []
xref: EC:3.1.21.5
xref: MetaCyc:3.1.21.5-RXN
is_a: GO:0015666 ! restriction endodeoxyribonuclease activity
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0015669
name: gas transport
namespace: biological_process
def: "The directed movement of substances that are gaseous in normal living conditions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0015670
name: carbon dioxide transport
namespace: biological_process
def: "The directed movement of carbon dioxide (CO2) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015669 ! gas transport

[Term]
id: GO:0015671
name: oxygen transport
namespace: biological_process
def: "The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015669 ! gas transport

[Term]
id: GO:0015672
name: monovalent inorganic cation transport
namespace: biological_process
def: "The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006812 ! cation transport

[Term]
id: GO:0015673
name: silver ion transport
namespace: biological_process
def: "The directed movement of silver (Ag) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
synonym: "silver transport" EXACT []
is_a: GO:0000041 ! transition metal ion transport
is_a: GO:0015672 ! monovalent inorganic cation transport

[Term]
id: GO:0015674
name: di-, tri-valent inorganic cation transport
namespace: biological_process
def: "The directed movement of inorganic cations with a valency of two or three into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006812 ! cation transport

[Term]
id: GO:0015675
name: nickel ion transport
namespace: biological_process
def: "The directed movement of nickel (Ni) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0015676
name: vanadium ion transport
namespace: biological_process
def: "The directed movement of vanadium (V) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0000041 ! transition metal ion transport

[Term]
id: GO:0015677
name: copper ion import
namespace: biological_process
def: "The directed movement of copper ions into a cell or organelle." [GOC:ai]
synonym: "copper ion uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006825 ! copper ion transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0015678
name: high-affinity copper ion transport
namespace: biological_process
def: "The directed, high-affinity movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah]
synonym: "high affinity copper ion transport" EXACT []
synonym: "high affinity copper transport" EXACT []
is_a: GO:0006825 ! copper ion transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0015679
name: plasma membrane copper ion transport
namespace: biological_process
def: "The directed movement of copper ions across the plasma membrane." [GOC:ai]
synonym: "plasma membrane copper transport" EXACT []
is_a: GO:0006825 ! copper ion transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0015680
name: intracellular copper ion transport
namespace: biological_process
def: "The directed movement of copper (Cu) ions within a cell." [GOC:ai]
synonym: "intracellular copper delivery" EXACT []
is_a: GO:0006825 ! copper ion transport
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0015682
name: ferric iron transport
namespace: biological_process
def: "The directed movement of ferric iron (Fe(III) or Fe3+) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "ferric ion transport" EXACT []
is_a: GO:0006826 ! iron ion transport

[Term]
id: GO:0015683
name: high-affinity ferric iron transport
namespace: biological_process
def: "The directed, high-affinity movement of ferric (Fe(III) or Fe3+) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah]
synonym: "high affinity ferric iron transport" EXACT []
is_a: GO:0006827 ! high-affinity iron ion transport
is_a: GO:0015682 ! ferric iron transport

[Term]
id: GO:0015684
name: ferrous iron transport
namespace: biological_process
def: "The directed movement of ferrous iron (Fe(II) or Fe2+) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "ferrous ion transport" EXACT []
is_a: GO:0006826 ! iron ion transport
is_a: GO:0070838 ! divalent metal ion transport

[Term]
id: GO:0015685
name: ferric-enterobactin transport
namespace: biological_process
def: "The directed movement of ferric-enterobactin into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015682 ! ferric iron transport
is_a: GO:0015892 ! siderophore-iron transport
is_a: GO:0042930 ! enterobactin transport

[Term]
id: GO:0015686
name: ferric triacetylfusarinine C transport
namespace: biological_process
def: "The directed movement of ferric triacetylfusarinine C into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015682 ! ferric iron transport
is_a: GO:0015892 ! siderophore-iron transport

[Term]
id: GO:0015687
name: ferric-hydroxamate transport
namespace: biological_process
def: "The directed movement of ferric-hydroxamate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015682 ! ferric iron transport
is_a: GO:0015892 ! siderophore-iron transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0015688
name: iron chelate transport
namespace: biological_process
def: "The directed movement of iron chelates into, out of, within or between cells by means of some external agent such as a transporter or pore. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006826 ! iron ion transport

[Term]
id: GO:0015689
name: molybdate ion transport
namespace: biological_process
def: "The directed movement of molybdate (MoO4 2-) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015690
name: aluminum ion transport
namespace: biological_process
def: "The directed movement of aluminum (Al) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
synonym: "aluminium ion transport" EXACT []
synonym: "aluminium transport" EXACT []
synonym: "aluminum transport" EXACT []
is_a: GO:0015674 ! di-, tri-valent inorganic cation transport
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0015691
name: cadmium ion transport
namespace: biological_process
def: "The directed movement of cadmium (Cd) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "cadmium transport" EXACT []
is_a: GO:0000041 ! transition metal ion transport
is_a: GO:0015674 ! di-, tri-valent inorganic cation transport

[Term]
id: GO:0015692
name: lead ion transport
namespace: biological_process
def: "The directed movement of lead (Pb) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0015693
name: magnesium ion transport
namespace: biological_process
def: "The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "magnesium transport" RELATED []
is_a: GO:0070838 ! divalent metal ion transport

[Term]
id: GO:0015694
name: mercury ion transport
namespace: biological_process
def: "The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "mercuric ion transport" NARROW []
synonym: "mercury transport" EXACT []
is_a: GO:0000041 ! transition metal ion transport
is_a: GO:0015674 ! di-, tri-valent inorganic cation transport
relationship: part_of GO:0050787 ! detoxification of mercury ion

[Term]
id: GO:0015695
name: organic cation transport
namespace: biological_process
def: "The directed movement of organic cations into, out of, within or between cells by means of some external agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006812 ! cation transport

[Term]
id: GO:0015696
name: ammonium transport
namespace: biological_process
def: "The directed movement of ammonium into, out of, within or between cells by means of some external agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ammonia transport" RELATED []
is_a: GO:0015695 ! organic cation transport

[Term]
id: GO:0015697
name: quaternary ammonium group transport
namespace: biological_process
alt_id: GO:0015845
def: "The directed movement into, out of, within or between cells by means of some external agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "quaternary amine transport" EXACT []
synonym: "quaternary ammonium compound transport" EXACT []
is_a: GO:0015695 ! organic cation transport
is_a: GO:0015837 ! amine transport

[Term]
id: GO:0015698
name: inorganic anion transport
namespace: biological_process
def: "The directed movement of inorganic anions into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:krc]
subset: gosubset_prok
is_a: GO:0006820 ! anion transport

[Term]
id: GO:0015699
name: antimonite transport
namespace: biological_process
def: "The directed movement of antimonite into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015700
name: arsenite transport
namespace: biological_process
def: "The directed movement of arsenite into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015701
name: bicarbonate transport
namespace: biological_process
def: "The directed movement of bicarbonate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015698 ! inorganic anion transport
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0015702
name: chlorate transport
namespace: biological_process
def: "The directed movement of chlorate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015703
name: chromate transport
namespace: biological_process
def: "The directed movement of chromate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015704
name: cyanate transport
namespace: biological_process
def: "The directed movement of cyanate, NCO-, the anion of cyanic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015705
name: iodide transport
namespace: biological_process
def: "The directed movement of iodide into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015706
name: nitrate transport
namespace: biological_process
alt_id: GO:0006872
def: "The directed movement of nitrate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015707
name: nitrite transport
namespace: biological_process
def: "The directed movement of nitrite into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015708
name: silicate transport
namespace: biological_process
def: "The directed movement of silicates into, out of, within or between cells by means of some external agent such as a transporter or pore. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:krc]
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015709
name: thiosulfate transport
namespace: biological_process
def: "The directed movement of thiosulfate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
synonym: "thiosulphate transport" EXACT []
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015710
name: tellurite transport
namespace: biological_process
def: "The directed movement of tellurite into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0015711
name: organic anion transport
namespace: biological_process
def: "The directed movement of organic anions into, out of, within or between cells by means of some external agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc]
subset: gosubset_prok
is_a: GO:0006820 ! anion transport

[Term]
id: GO:0015712
name: hexose phosphate transport
namespace: biological_process
def: "The directed movement of hexose phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015713
name: phosphoglycerate transport
namespace: biological_process
def: "The directed movement of phosphoglycerate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015849 ! organic acid transport

[Term]
id: GO:0015714
name: phosphoenolpyruvate transport
namespace: biological_process
def: "The directed movement of phosphoenolpyruvate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0015715
name: nucleotide-sulfate transport
namespace: biological_process
synonym: "nucleotide-sulphate transport" EXACT []
is_a: GO:0008272 ! sulfate transport

[Term]
id: GO:0015716
name: phosphonate transport
namespace: biological_process
def: "The directed movement of phosphonates into, out of, within or between cells by means of some external agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0015717
name: triose phosphate transport
namespace: biological_process
def: "The directed movement of triose phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015749 ! monosaccharide transport

[Term]
id: GO:0015718
name: monocarboxylic acid transport
namespace: biological_process
def: "The directed movement of monocarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0046942 ! carboxylic acid transport

[Term]
id: GO:0015719
name: allantoate transport
namespace: biological_process
def: "The directed movement of allantoate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
synonym: "allantoin/allantoate transport" BROAD []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0015720
name: allantoin transport
namespace: biological_process
def: "The directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "allantoin/allantoate transport" BROAD []
is_a: GO:0015851 ! nucleobase transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0015721
name: bile acid and bile salt transport
namespace: biological_process
def: "The directed movement of bile acid and bile salts into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511]
synonym: "bile acid transport" NARROW []
synonym: "bile salt transport" NARROW []
xref: Reactome:159418 "Recycling of bile acids and salts"
xref: Reactome:448983 "Recycling of bile acids and salts"
xref: Reactome:470097 "Recycling of bile acids and salts"
xref: Reactome:487793 "Recycling of bile acids and salts"
xref: Reactome:507757 "Recycling of bile acids and salts"
xref: Reactome:517918 "Recycling of bile acids and salts"
xref: Reactome:526533 "Recycling of bile acids and salts"
xref: Reactome:531511 "Recycling of bile acids and salts"
xref: Reactome:536902 "Recycling of bile acids and salts"
xref: Reactome:542650 "Recycling of bile acids and salts"
xref: Reactome:547965 "Recycling of bile acids and salts"
xref: Reactome:552538 "Recycling of bile acids and salts"
xref: Reactome:558164 "Recycling of bile acids and salts"
xref: Reactome:568792 "Recycling of bile acids and salts"
xref: Reactome:581995 "Recycling of bile acids and salts"
xref: Reactome:586041 "Recycling of bile acids and salts"
xref: Reactome:592902 "Recycling of bile acids and salts"
xref: Reactome:595596 "Recycling of bile acids and salts"
xref: Reactome:599787 "Recycling of bile acids and salts"
xref: Reactome:600703 "Recycling of bile acids and salts"
xref: Reactome:602626 "Recycling of bile acids and salts"
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0015722
name: canalicular bile acid transport
namespace: biological_process
is_a: GO:0015721 ! bile acid and bile salt transport

[Term]
id: GO:0015723
name: bilirubin transport
namespace: biological_process
def: "The directed movement of bilirubin into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0015724
name: formate transport
namespace: biological_process
def: "The directed movement of formate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0015725
name: gluconate transport
namespace: biological_process
def: "The directed movement of gluconate into, out of, within or between cells by means of some external agent such as a transporter or pore. Gluconate is the aldonic acid derived from glucose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0042873 ! aldonate transport

[Term]
id: GO:0015726
name: L-idonate transport
namespace: biological_process
def: "The directed movement of L-idonate into, out of, within or between cells by means of some external agent such as a transporter or pore. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0042873 ! aldonate transport

[Term]
id: GO:0015727
name: lactate transport
namespace: biological_process
def: "The directed movement of lactate into, out of, within or between cells by means of some external agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0015728
name: mevalonate transport
namespace: biological_process
def: "The directed movement of mevalonate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0015729
name: oxaloacetate transport
namespace: biological_process
def: "The directed movement of oxaloacetate, the anion of oxobutanedioic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
is_a: GO:0006835 ! dicarboxylic acid transport

[Term]
id: GO:0015730
name: propionate transport
namespace: biological_process
def: "The directed movement of propionate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
synonym: "propanoate transport" EXACT []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0015731
name: 3-hydroxyphenyl propanoate transport
namespace: biological_process
def: "The directed movement of 3-hydroxyphenyl propanoate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
synonym: "3-hydroxyphenyl propionate transport" EXACT []
is_a: GO:0015730 ! propionate transport

[Term]
id: GO:0015732
name: prostaglandin transport
namespace: biological_process
def: "The directed movement of prostaglandins into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015908 ! fatty acid transport

[Term]
id: GO:0015733
name: shikimate transport
namespace: biological_process
def: "The directed movement of shikimate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0015734
name: taurine transport
namespace: biological_process
def: "The directed movement of taurine into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0015735
name: uronic acid transport
namespace: biological_process
def: "The directed movement of uronic acid into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015749 ! monosaccharide transport

[Term]
id: GO:0015736
name: hexuronate transport
namespace: biological_process
def: "The directed movement of hexuronate into, out of, within or between cells by means of some external agent such as a transporter or pore. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015735 ! uronic acid transport

[Term]
id: GO:0015737
name: galacturonate transport
namespace: biological_process
def: "The directed movement of galacturonate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015736 ! hexuronate transport

[Term]
id: GO:0015738
name: glucuronate transport
namespace: biological_process
def: "The directed movement of glucuronate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
is_a: GO:0015736 ! hexuronate transport

[Term]
id: GO:0015739
name: sialic acid transport
namespace: biological_process
def: "The directed movement of sialic acid into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015749 ! monosaccharide transport

[Term]
id: GO:0015740
name: C4-dicarboxylate transport
namespace: biological_process
def: "The directed movement of a C4-dicarboxylate into, out of, within or between cells by means of some external agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms." [GOC:krc, GOC:mah]
subset: gosubset_prok
is_a: GO:0006835 ! dicarboxylic acid transport

[Term]
id: GO:0015741
name: fumarate transport
namespace: biological_process
def: "The directed movement of fumarate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0015742
name: alpha-ketoglutarate transport
namespace: biological_process
def: "The directed movement of alpha-ketoglutarate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
synonym: "2-oxoglutarate transport" EXACT []
synonym: "mitochondrial alpha-ketoglutarate/malate transport" NARROW []
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0015743
name: malate transport
namespace: biological_process
def: "The directed movement of malate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
synonym: "mitochondrial alpha-ketoglutarate/malate transport" NARROW []
is_a: GO:0015740 ! C4-dicarboxylate transport

[Term]
id: GO:0015744
name: succinate transport
namespace: biological_process
def: "The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015740 ! C4-dicarboxylate transport

[Term]
id: GO:0015745
name: tartrate transport
namespace: biological_process
def: "The directed movement of tartrate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0042869 ! aldarate transport

[Term]
id: GO:0015746
name: citrate transport
namespace: biological_process
def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
subset: gosubset_prok
is_a: GO:0006842 ! tricarboxylic acid transport
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0015747
name: urate transport
namespace: biological_process
def: "The directed movement of urate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc]
synonym: "uric acid transport" EXACT []
is_a: GO:0006863 ! purine transport
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015849 ! organic acid transport

[Term]
id: GO:0015748
name: organophosphate ester transport
namespace: biological_process
def: "The directed movement of organophosphate esters into, out of, within or between cells by means of some external agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc]
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0015749
name: monosaccharide transport
namespace: biological_process
def: "The directed movement of monosaccharides into, out of, within or between cells by means of some external agent such as a transporter or pore. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0015750
name: pentose transport
namespace: biological_process
def: "The directed movement of pentoses into, out of, within or between cells by means of some external agent such as a transporter or pore. A pentose is any aldose with a chain of five carbon atoms in the molecule." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015749 ! monosaccharide transport

[Term]
id: GO:0015751
name: arabinose transport
namespace: biological_process
def: "The directed movement of arabinose, a pentose monosaccharide that occurs in both D and L configurations, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0015750 ! pentose transport

[Term]
id: GO:0015752
name: D-ribose transport
namespace: biological_process
def: "The directed movement of D-ribose into, out of, within or between cells by means of some external agent such as a transporter or pore. As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015750 ! pentose transport

[Term]
id: GO:0015753
name: D-xylose transport
namespace: biological_process
def: "The directed movement of D-xylose into, out of, within or between cells by means of some external agent such as a transporter or pore. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015750 ! pentose transport

[Term]
id: GO:0015754
name: allose transport
namespace: biological_process
def: "The directed movement of allose into, out of, within or between cells by means of some external agent such as a transporter or pore. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015755
name: fructose transport
namespace: biological_process
def: "The directed movement of fructose into, out of, within or between cells by means of some external agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015756
name: fucose transport
namespace: biological_process
def: "The directed movement of fucose into, out of, within or between cells by means of some external agent such as a transporter or pore. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015757
name: galactose transport
namespace: biological_process
def: "The directed movement of galactose into, out of, within or between cells by means of some external agent such as a transporter or pore. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015758
name: glucose transport
namespace: biological_process
def: "The directed movement of the hexose monosaccharide glucose into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015759
name: beta-glucoside transport
namespace: biological_process
def: "The directed movement of beta-glucosides into, out of, within or between cells by means of some external agent such as a transporter or pore. Beta-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0042946 ! glucoside transport

[Term]
id: GO:0015760
name: glucose-6-phosphate transport
namespace: biological_process
def: "The directed movement of glucose-6-phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]
is_a: GO:0015712 ! hexose phosphate transport
is_a: GO:0015758 ! glucose transport

[Term]
id: GO:0015761
name: mannose transport
namespace: biological_process
def: "The directed movement of mannose into, out of, within or between cells by means of some external agent such as a transporter or pore. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015762
name: rhamnose transport
namespace: biological_process
def: "The directed movement of rhamnose into, out of, within or between cells by means of some external agent such as a transporter or pore. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015763
name: N-acetylgalactosamine transport
namespace: biological_process
def: "The directed movement of N-acetylgalactosamine into, out of, within or between cells by means of some external agent such as a transporter or pore. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015764
name: N-acetylglucosamine transport
namespace: biological_process
def: "The directed movement of N-acetylglucosamine into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015765
name: methylgalactoside transport
namespace: biological_process
def: "The directed movement of methylgalactoside into, out of, within or between cells by means of some external agent such as a transporter or pore. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0015766
name: disaccharide transport
namespace: biological_process
def: "The directed movement of disaccharides into, out of, within or between cells by means of some external agent such as a transporter or pore. Disaccharides are sugars composed of two monosaccharide units." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015772 ! oligosaccharide transport

[Term]
id: GO:0015767
name: lactose transport
namespace: biological_process
def: "The directed movement of lactose into, out of, within or between cells by means of some external agent such as a transporter or pore. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0015768
name: maltose transport
namespace: biological_process
def: "The directed movement of maltose into, out of, within or between cells by means of some external agent such as a transporter or pore. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch." [GOC:ai]
subset: gosubset_prok
is_a: GO:0000017 ! alpha-glucoside transport
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0015769
name: melibiose transport
namespace: biological_process
def: "The directed movement of melibiose into, out of, within or between cells by means of some external agent such as a transporter or pore. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0015770
name: sucrose transport
namespace: biological_process
def: "The directed movement of sucrose into, out of, within or between cells by means of some external agent such as a transporter or pore. Sucrose is the disaccharide fructofuranosyl-glucopyranoside." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0015771
name: trehalose transport
namespace: biological_process
def: "The directed movement of trehalose into, out of, within or between cells by means of some external agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:ai]
subset: gosubset_prok
is_a: GO:0000017 ! alpha-glucoside transport
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0015772
name: oligosaccharide transport
namespace: biological_process
def: "The directed movement of oligosaccharides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligosaccharides are molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0015773
name: raffinose transport
namespace: biological_process
def: "The directed movement of raffinose into, out of, within or between cells by means of some external agent such as a transporter or pore. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0015772 ! oligosaccharide transport

[Term]
id: GO:0015774
name: polysaccharide transport
namespace: biological_process
def: "The directed movement of polysaccharides into, out of, within or between cells by means of some external agent such as a transporter or pore. A polysaccharide is a polymer of more than about 10 monosaccharide residues joined by glycosidic linkages." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008643 ! carbohydrate transport
relationship: part_of GO:0033037 ! polysaccharide localization

[Term]
id: GO:0015775
name: beta-glucan transport
namespace: biological_process
def: "The directed movement of beta-glucans into, out of, within or between cells by means of some external agent such as a transporter or pore. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai]
is_a: GO:0015774 ! polysaccharide transport

[Term]
id: GO:0015776
name: capsular polysaccharide transport
namespace: biological_process
def: "The directed movement of capsular polysaccharides into, out of, within or between cells by means of some external agent such as a transporter or pore. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai]
subset: gosubset_prok
synonym: "capsular-polysaccharide transport" EXACT []
synonym: "capsule polysaccharide transport" EXACT []
is_a: GO:0015774 ! polysaccharide transport

[Term]
id: GO:0015777
name: teichoic acid transport
namespace: biological_process
def: "The directed movement of teichoic acid into, out of, within or between cells by means of some external agent such as a transporter or pore. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015774 ! polysaccharide transport

[Term]
id: GO:0015778
name: hexuronide transport
namespace: biological_process
def: "The directed movement of hexuronide into, out of, within or between cells by means of some external agent such as a transporter or pore. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0015779
name: glucuronoside transport
namespace: biological_process
def: "The directed movement of glucuronosides into, out of, within or between cells by means of some external agent such as a transporter or pore. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai]
subset: gosubset_prok
synonym: "glucuronide transport" EXACT []
is_a: GO:0015778 ! hexuronide transport

[Term]
id: GO:0015780
name: nucleotide-sugar transport
namespace: biological_process
def: "The directed movement of nucleotide-sugars into, out of, within or between cells by means of some external agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0015781
name: pyrimidine nucleotide-sugar transport
namespace: biological_process
def: "The directed movement of pyrimidine nucleotide-sugars into, out of, within or between cells by means of some external agent such as a transporter or pore. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai]
is_a: GO:0015780 ! nucleotide-sugar transport

[Term]
id: GO:0015782
name: CMP-sialic acid transport
namespace: biological_process
def: "The directed movement of CMP-sialic acid into, out of, within or between cells by means of some external agent such as a transporter or pore. CMP-sialic acid is a substance composed of sialic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai]
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport

[Term]
id: GO:0015783
name: GDP-fucose transport
namespace: biological_process
def: "The directed movement of GDP-fucose into, out of, within or between cells by means of some external agent such as a transporter or pore. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport

[Term]
id: GO:0015784
name: GDP-mannose transport
namespace: biological_process
def: "The directed movement of GDP-mannose into, out of, within or between cells by means of some external agent such as a transporter or pore. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport

[Term]
id: GO:0015785
name: UDP-galactose transport
namespace: biological_process
def: "The directed movement of UDP-galactose into, out of, within or between cells by means of some external agent such as a transporter or pore. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai]
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport

[Term]
id: GO:0015786
name: UDP-glucose transport
namespace: biological_process
def: "The directed movement of UDP-glucose into, out of, within or between cells by means of some external agent such as a transporter or pore. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai]
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport

[Term]
id: GO:0015787
name: UDP-glucuronic acid transport
namespace: biological_process
def: "The directed movement of UDP-glucuronic acid into, out of, within or between cells by means of some external agent such as a transporter or pore. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai]
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport

[Term]
id: GO:0015788
name: UDP-N-acetylglucosamine transport
namespace: biological_process
def: "The directed movement of UDP-N-acetylglucosamine into, out of, within or between cells by means of some external agent such as a transporter or pore. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport

[Term]
id: GO:0015789
name: UDP-N-acetylgalactosamine transport
namespace: biological_process
def: "The directed movement of UDP-N-acetylgalactosamine into, out of, within or between cells by means of some external agent such as a transporter or pore. UDP-N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport

[Term]
id: GO:0015790
name: UDP-xylose transport
namespace: biological_process
def: "The directed movement of UDP-xylose into, out of, within or between cells by means of some external agent such as a transporter or pore. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai]
is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport

[Term]
id: GO:0015791
name: polyol transport
namespace: biological_process
def: "The directed movement of polyols, any polyhydric alcohol, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0015850 ! organic alcohol transport

[Term]
id: GO:0015792
name: arabinitol transport
namespace: biological_process
def: "The directed movement of arabitol into, out of, within or between cells by means of some external agent such as a transporter or pore. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "arabitol transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0015791 ! polyol transport

[Term]
id: GO:0015793
name: glycerol transport
namespace: biological_process
def: "The directed movement of glycerol into, out of, within or between cells by means of some external agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0015791 ! polyol transport

[Term]
id: GO:0015794
name: glycerol-3-phosphate transport
namespace: biological_process
def: "The directed movement of glycerol-3-phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015793 ! glycerol transport

[Term]
id: GO:0015795
name: sorbitol transport
namespace: biological_process
def: "The directed movement of sorbitol into, out of, within or between cells by means of some external agent such as a transporter or pore. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glucitol transport" EXACT []
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0015791 ! polyol transport

[Term]
id: GO:0015796
name: galactitol transport
namespace: biological_process
def: "The directed movement of galactitol into, out of, within or between cells by means of some external agent such as a transporter or pore. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0015791 ! polyol transport

[Term]
id: GO:0015797
name: mannitol transport
namespace: biological_process
def: "The directed movement of mannitol into, out of, within or between cells by means of some external agent such as a transporter or pore. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0015791 ! polyol transport

[Term]
id: GO:0015798
name: myo-inositol transport
namespace: biological_process
def: "The directed movement of myo-inositol into, out of, within or between cells by means of some external agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin Bh transport" EXACT []
is_a: GO:0015791 ! polyol transport

[Term]
id: GO:0015799
name: propanediol transport
namespace: biological_process
def: "The directed movement of propanediol into, out of, within or between cells by means of some external agent such as a transporter or pore. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [http://www.rhymezone.com]
is_a: GO:0015791 ! polyol transport

[Term]
id: GO:0015800
name: acidic amino acid transport
namespace: biological_process
def: "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015801
name: aromatic amino acid transport
namespace: biological_process
def: "The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015802
name: basic amino acid transport
namespace: biological_process
def: "The directed movement of basic amino acids, amino acids with a pH above 7, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015803
name: branched-chain aliphatic amino acid transport
namespace: biological_process
def: "The directed movement of branched-chain aliphatic amino acids, amino acids with branched carbon skeleton without rings, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015804
name: neutral amino acid transport
namespace: biological_process
def: "The directed movement of neutral amino acids, amino acids with no net charge, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015805
name: S-adenosylmethionine transport
namespace: biological_process
def: "The directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
synonym: "S-adenosyl methionine transport" EXACT []
is_a: GO:0000101 ! sulfur amino acid transport

[Term]
id: GO:0015806
name: S-methylmethionine transport
namespace: biological_process
def: "The directed movement of S-methylmethionine into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0000101 ! sulfur amino acid transport

[Term]
id: GO:0015807
name: L-amino acid transport
namespace: biological_process
def: "The directed movement of L-enantiomer amino acids into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015808
name: L-alanine transport
namespace: biological_process
def: "The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0032328 ! alanine transport

[Term]
id: GO:0015809
name: arginine transport
namespace: biological_process
def: "The directed movement of arginine, 2-amino-5-guanidinopentanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "L-arginine transport" NARROW []
is_a: GO:0015802 ! basic amino acid transport

[Term]
id: GO:0015810
name: aspartate transport
namespace: biological_process
def: "The directed movement of aspartate, the anion of aspartic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "mitochondrial aspartate/glutamate transport" RELATED []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015800 ! acidic amino acid transport

[Term]
id: GO:0015811
name: L-cystine transport
namespace: biological_process
def: "The directed movement of L-cystine (also known as dicysteine) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0000101 ! sulfur amino acid transport
is_a: GO:0015807 ! L-amino acid transport

[Term]
id: GO:0015812
name: gamma-aminobutyric acid transport
namespace: biological_process
def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: See also the biological process term 'neurotransmitter transport ; GO:0006836'.
subset: gosubset_prok
synonym: "4-aminobutanoate transport" EXACT []
synonym: "4-aminobutyrate transport" EXACT []
synonym: "GABA transport" EXACT []
is_a: GO:0015807 ! L-amino acid transport

[Term]
id: GO:0015813
name: L-glutamate transport
namespace: biological_process
def: "The directed movement of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "mitochondrial aspartate/glutamate transport" RELATED []
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015800 ! acidic amino acid transport

[Term]
id: GO:0015814
name: p-aminobenzoyl-glutamate transport
namespace: biological_process
def: "The directed movement of p-aminobenzoyl-glutamate, the anion of p-aminobenzoyl-glutamic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015813 ! L-glutamate transport

[Term]
id: GO:0015816
name: glycine transport
namespace: biological_process
def: "The directed movement of glycine, aminoethanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0015817
name: histidine transport
namespace: biological_process
def: "The directed movement of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-histidine transport" NARROW []
is_a: GO:0015802 ! basic amino acid transport

[Term]
id: GO:0015818
name: isoleucine transport
namespace: biological_process
def: "The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-isoleucine transport" NARROW []
is_a: GO:0015803 ! branched-chain aliphatic amino acid transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0015819
name: lysine transport
namespace: biological_process
def: "The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-lysine transport" NARROW []
is_a: GO:0015802 ! basic amino acid transport

[Term]
id: GO:0015820
name: leucine transport
namespace: biological_process
def: "The directed movement of leucine, 2-amino-4-methylpentanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-leucine transport" NARROW []
is_a: GO:0015803 ! branched-chain aliphatic amino acid transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0015821
name: methionine transport
namespace: biological_process
def: "The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-methionine transport" NARROW []
is_a: GO:0000101 ! sulfur amino acid transport

[Term]
id: GO:0015822
name: ornithine transport
namespace: biological_process
def: "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-ornithine transport" NARROW []
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0015823
name: phenylalanine transport
namespace: biological_process
def: "The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-phenylalanine transport" NARROW []
is_a: GO:0015801 ! aromatic amino acid transport

[Term]
id: GO:0015824
name: proline transport
namespace: biological_process
def: "The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-proline transport" NARROW []
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0015825
name: L-serine transport
namespace: biological_process
def: "The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0032329 ! serine transport

[Term]
id: GO:0015826
name: threonine transport
namespace: biological_process
def: "The directed movement of threonine, (2R*,3S*)-2-amino-3-hydroxybutanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-threonine transport" NARROW []
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0015827
name: tryptophan transport
namespace: biological_process
def: "The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-tryptophan transport" NARROW []
is_a: GO:0015801 ! aromatic amino acid transport

[Term]
id: GO:0015828
name: tyrosine transport
namespace: biological_process
def: "The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-tyrosine transport" NARROW []
is_a: GO:0015801 ! aromatic amino acid transport

[Term]
id: GO:0015829
name: valine transport
namespace: biological_process
def: "The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "L-valine transport" NARROW []
is_a: GO:0015803 ! branched-chain aliphatic amino acid transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0015830
name: diaminopimelate transport
namespace: biological_process
def: "The directed movement of diaminopimelate, the anion of 2,6-diaminoheptanedioic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0015711 ! organic anion transport
is_a: GO:0015807 ! L-amino acid transport

[Term]
id: GO:0015832
name: holin
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
consider: GO:0008565
consider: GO:0019835

[Term]
id: GO:0015833
name: peptide transport
namespace: biological_process
def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0015834
name: peptidoglycan-associated peptide transport
namespace: biological_process
def: "The directed movement of peptidoglycan peptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "murein peptide transport" EXACT []
synonym: "muropeptide transport" EXACT []
synonym: "peptidoglycan peptide transport" EXACT [GOC:mah]
is_a: GO:0015833 ! peptide transport

[Term]
id: GO:0015835
name: peptidoglycan transport
namespace: biological_process
def: "The directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "murein transport" EXACT []
is_a: GO:0006810 ! transport

[Term]
id: GO:0015836
name: lipid-linked peptidoglycan transport
namespace: biological_process
synonym: "lipid-linked murein transport" EXACT []
is_a: GO:0015835 ! peptidoglycan transport

[Term]
id: GO:0015837
name: amine transport
namespace: biological_process
def: "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
synonym: "amine/polyamine transport" RELATED []
is_a: GO:0006810 ! transport

[Term]
id: GO:0015838
name: betaine transport
namespace: biological_process
def: "The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015697 ! quaternary ammonium group transport

[Term]
id: GO:0015839
name: cadaverine transport
namespace: biological_process
def: "The directed movement of cadaverine, 1,5-pentanediamine, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015837 ! amine transport

[Term]
id: GO:0015840
name: urea transport
namespace: biological_process
def: "The directed movement into, out of or within the cell of urea, the water-soluble compound H2N-CO-NH2, produced in the liver via the ornithine-urea cycle." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0015841
name: chromaffin granule amine transport
namespace: biological_process
is_a: GO:0015837 ! amine transport

[Term]
id: GO:0015842
name: synaptic vesicle amine transport
namespace: biological_process
def: "The directed movement of amines into, out of or within synaptic vesicles." [GOC:ai]
is_a: GO:0015837 ! amine transport
is_a: GO:0048489 ! synaptic vesicle transport

[Term]
id: GO:0015843
name: methylammonium transport
namespace: biological_process
def: "The directed movement of methylammonium into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015837 ! amine transport

[Term]
id: GO:0015844
name: monoamine transport
namespace: biological_process
alt_id: GO:0015873
def: "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of, within or between cells by means of some external agent such as a transporter or pore." [ChEBI:25375, GOC:mah]
subset: gosubset_prok
is_a: GO:0015837 ! amine transport

[Term]
id: GO:0015846
name: polyamine transport
namespace: biological_process
def: "The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015837 ! amine transport

[Term]
id: GO:0015847
name: putrescine transport
namespace: biological_process
def: "The directed movement of putrescine into, out of, within or between cells by means of some external agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015846 ! polyamine transport

[Term]
id: GO:0015848
name: spermidine transport
namespace: biological_process
def: "The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015846 ! polyamine transport

[Term]
id: GO:0015849
name: organic acid transport
namespace: biological_process
def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of, within or between cells by means of some external agent such as a transporter or pore." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0015850
name: organic alcohol transport
namespace: biological_process
def: "The directed movement of organic alcohols into, out of, within or between cells by means of some external agent such as a transporter or pore. An organic alcohol is any carbon-containing compound containing a hydroxyl group." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0015851
name: nucleobase transport
namespace: biological_process
def: "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport

[Term]
id: GO:0015853
name: adenine transport
namespace: biological_process
def: "The directed movement of adenine, 6-aminopurine, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0006863 ! purine transport

[Term]
id: GO:0015854
name: guanine transport
namespace: biological_process
def: "The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators]
is_a: GO:0006863 ! purine transport

[Term]
id: GO:0015855
name: pyrimidine transport
namespace: biological_process
def: "The directed movement of pyrimidines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015851 ! nucleobase transport

[Term]
id: GO:0015856
name: cytosine transport
namespace: biological_process
def: "The directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0015855 ! pyrimidine transport

[Term]
id: GO:0015857
name: uracil transport
namespace: biological_process
def: "The directed movement of uracil, 2,4-dioxopyrimidine, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0015855 ! pyrimidine transport

[Term]
id: GO:0015858
name: nucleoside transport
namespace: biological_process
def: "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport

[Term]
id: GO:0015859
name: intracellular nucleoside transport
namespace: biological_process
def: "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), within a cell." [GOC:ai]
is_a: GO:0015858 ! nucleoside transport
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0015860
name: purine nucleoside transport
namespace: biological_process
def: "The directed movement of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015858 ! nucleoside transport

[Term]
id: GO:0015861
name: cytidine transport
namespace: biological_process
def: "The directed movement of cytidine, cytosine riboside, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators]
is_a: GO:0015864 ! pyrimidine nucleoside transport

[Term]
id: GO:0015862
name: uridine transport
namespace: biological_process
def: "The directed movement of uridine, uracil riboside, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators]
is_a: GO:0015864 ! pyrimidine nucleoside transport

[Term]
id: GO:0015863
name: xanthosine transport
namespace: biological_process
def: "The directed movement of xanthosine, xanthine riboside, into, out of, within or between cells by means of some external agent such as a transporter or pore." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015860 ! purine nucleoside transport

[Term]
id: GO:0015864
name: pyrimidine nucleoside transport
namespace: biological_process
def: "The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015858 ! nucleoside transport

[Term]
id: GO:0015865
name: purine nucleotide transport
namespace: biological_process
def: "The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai]
is_a: GO:0006862 ! nucleotide transport

[Term]
id: GO:0015866
name: ADP transport
namespace: biological_process
def: "The directed movement of ADP, adenosine diphosphate, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport

[Term]
id: GO:0015867
name: ATP transport
namespace: biological_process
def: "The directed movement of ATP, adenosine triphosphate, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015868 ! purine ribonucleotide transport
is_a: GO:0051503 ! adenine nucleotide transport

[Term]
id: GO:0015868
name: purine ribonucleotide transport
namespace: biological_process
def: "The directed movement of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai]
is_a: GO:0015865 ! purine nucleotide transport

[Term]
id: GO:0015869
name: protein-DNA complex transport
namespace: biological_process
def: "The directed movement of protein-DNA complexes into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "DNA-protein complex transport" EXACT [GOC:mah]
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport

[Term]
id: GO:0015870
name: acetylcholine transport
namespace: biological_process
def: "The directed movement of acetylcholine into, out of, within or between cells by means of some external agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
is_a: GO:0006836 ! neurotransmitter transport
is_a: GO:0015837 ! amine transport

[Term]
id: GO:0015871
name: choline transport
namespace: biological_process
def: "The directed movement of choline into, out of, within or between cells by means of some external agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai]
is_a: GO:0015697 ! quaternary ammonium group transport
is_a: GO:0015850 ! organic alcohol transport

[Term]
id: GO:0015872
name: dopamine transport
namespace: biological_process
def: "The directed movement of dopamine into, out of, within or between cells by means of some external agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0015874
name: norepinephrine transport
namespace: biological_process
def: "The directed movement of norepinephrine into, out of, within or between cells by means of some external agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "levarterenol transport" EXACT []
synonym: "noradrenaline transport" EXACT []
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0015875
name: vitamin or cofactor transport
namespace: biological_process
def: "OBSOLETE. The directed movement of vitamins or cofactors into, out of, within or between cells." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
is_obsolete: true
consider: GO:0051180
consider: GO:0051181

[Term]
id: GO:0015876
name: acetyl-CoA transport
namespace: biological_process
def: "The directed movement of acetyl-CoA into, out of, within or between cells by means of some external agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai]
is_a: GO:0051182 ! coenzyme transport

[Term]
id: GO:0015877
name: biopterin transport
namespace: biological_process
def: "The directed movement of biopterin into, out of, within or between cells by means of some external agent such as a transporter or pore. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [GOC:ai]
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0015878
name: biotin transport
namespace: biological_process
def: "The directed movement of biotin into, out of, within or between cells by means of some external agent such as a transporter or pore. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai]
synonym: "vitamin B7 transport" EXACT []
synonym: "vitamin H transport" EXACT []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0042886 ! amide transport
is_a: GO:0051180 ! vitamin transport

[Term]
id: GO:0015879
name: carnitine transport
namespace: biological_process
def: "The directed movement of carnitine into, out of, within or between cells by means of some external agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin Bt transport" EXACT []
is_a: GO:0006865 ! amino acid transport
is_a: GO:0015838 ! betaine transport
is_a: GO:0051180 ! vitamin transport
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0015880
name: coenzyme A transport
namespace: biological_process
def: "The directed movement of coenzyme A into, out of, within or between cells by means of some external agent such as a transporter or pore. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai]
is_a: GO:0051182 ! coenzyme transport

[Term]
id: GO:0015881
name: creatine transport
namespace: biological_process
def: "The directed movement of creatine into, out of, within or between cells by means of some external agent such as a transporter or pore. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai]
is_a: GO:0006865 ! amino acid transport
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0015882
name: L-ascorbic acid transport
namespace: biological_process
def: "The directed movement of L-ascorbic acid into, out of, within or between cells by means of some external agent such as a transporter or pore. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [ChEBI:38290, GOC:ai]
synonym: "L-ascorbate transport" EXACT []
synonym: "vitamin C transport" EXACT []
is_a: GO:0046942 ! carboxylic acid transport
is_a: GO:0051180 ! vitamin transport

[Term]
id: GO:0015883
name: FAD transport
namespace: biological_process
def: "The directed movement of flavin-adenine dinucleotide (FAD) into, out of, within or between cells by means of some external agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "flavin adenine dinucleotide transport" EXACT []
synonym: "flavin-adenine dinucleotide transport" EXACT []
is_a: GO:0006862 ! nucleotide transport
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0015884
name: folic acid transport
namespace: biological_process
def: "The directed movement of folic acid (pteroylglutamic acid) into, out of, within or between cells by means of some external agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai]
synonym: "folate transport" EXACT []
synonym: "vitamin B9 transport" EXACT []
synonym: "vitamin M transport" EXACT []
is_a: GO:0006865 ! amino acid transport
is_a: GO:0051180 ! vitamin transport
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0015885
name: 5-formyltetrahydrofolate transport
namespace: biological_process
def: "The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0015886
name: heme transport
namespace: biological_process
def: "The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "haem transport" EXACT []
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0015887
name: pantothenate transport
namespace: biological_process
def: "The directed movement of pantothenate into, out of, within or between cells by means of some external agent such as a transporter or pore. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "pantothenate transmembrane transport" EXACT [GOC:mah]
synonym: "vitamin B5 transport" EXACT []
is_a: GO:0051180 ! vitamin transport
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0015888
name: thiamin transport
namespace: biological_process
def: "The directed movement of thiamin into, out of, within or between cells by means of some external agent such as a transporter or pore. Thiamin is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai]
subset: gosubset_prok
synonym: "thiamine transport" EXACT []
synonym: "vitamin B1 transport" EXACT []
is_a: GO:0051180 ! vitamin transport

[Term]
id: GO:0015889
name: cobalamin transport
namespace: biological_process
def: "The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin B12 transport" EXACT []
is_a: GO:0051180 ! vitamin transport

[Term]
id: GO:0015890
name: nicotinamide mononucleotide transport
namespace: biological_process
def: "The directed movement of nicotinamide mononucleotide into, out of, within or between cells by means of some external agent such as a transporter or pore. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of D-ribose. It is a constituent of NAD and NADP." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "nicotinamide ribonucleotide transport" EXACT []
is_a: GO:0006862 ! nucleotide transport
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0015891
name: siderophore transport
namespace: biological_process
def: "The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "siderochrome transport" NARROW []
is_a: GO:0006810 ! transport

[Term]
id: GO:0015892
name: siderophore-iron transport
namespace: biological_process
def: "The directed movement of iron-siderophores into, out of, within or between cells by means of some external agent such as a transporter or pore. Iron-siderophores are low molecular weight Fe(III)-chelating substances in the iron-bound form." [GOC:ai, GOC:mah]
subset: gosubset_prok
synonym: "iron-siderochrome transport" NARROW []
synonym: "iron-siderophore transport" EXACT []
is_a: GO:0015688 ! iron chelate transport
is_a: GO:0015891 ! siderophore transport
relationship: part_of GO:0033214 ! iron assimilation by chelation and transport

[Term]
id: GO:0015893
name: drug transport
namespace: biological_process
def: "The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport
relationship: part_of GO:0042493 ! response to drug

[Term]
id: GO:0015894
name: acriflavine transport
namespace: biological_process
def: "The directed movement of acriflavine into, out of, within or between cells by means of some external agent such as a transporter or pore. Acriflavine is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [http://cancerweb.ncl.ac.uk/]
synonym: "acriflavin transport" RELATED [GOC:dph, GOC:tb]
is_a: GO:0015893 ! drug transport
is_a: GO:0042908 ! xenobiotic transport

[Term]
id: GO:0015895
name: alkane transport
namespace: biological_process
def: "The directed movement of alkanes into, out of, within or between cells by means of some external agent such as a transporter or pore. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai]
is_a: GO:0006810 ! transport

[Term]
id: GO:0015896
name: nalidixic acid transport
namespace: biological_process
def: "The directed movement of nalidixic acid into, out of, within or between cells by means of some external agent such as a transporter or pore. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [http://cancerweb.ncl.ac.uk/]
is_a: GO:0042891 ! antibiotic transport
is_a: GO:0042908 ! xenobiotic transport

[Term]
id: GO:0015897
name: organomercurial transport
namespace: biological_process
def: "The directed movement of organomercurial compounds into, out of, within or between cells by means of some external agent such as a transporter or pore. Organomercurial substances are any organic compound containing a mercury atom." [GOC:ai]
is_a: GO:0015893 ! drug transport

[Term]
id: GO:0015898
name: amiloride transport
namespace: biological_process
def: "The directed movement amiloride into, out of, within or between cells by means of some external agent such as a transporter or pore. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [GOC:ai]
is_a: GO:0015893 ! drug transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0015899
name: aminotriazole transport
namespace: biological_process
def: "The directed movement of aminotriazole into, out of, within or between cells by means of some external agent such as a transporter or pore. Aminotriazole is an effective weed killer that also possesses some antithyroid activity." [http://cancerweb.ncl.ac.uk/]
is_a: GO:0015837 ! amine transport
is_a: GO:0045117 ! azole transport

[Term]
id: GO:0015900
name: benomyl transport
namespace: biological_process
def: "The directed movement of benomyl into, out of, within or between cells by means of some external agent such as a transporter or pore. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit." [http://cancerweb.ncl.ac.uk/]
is_a: GO:0015893 ! drug transport
is_a: GO:0042908 ! xenobiotic transport

[Term]
id: GO:0015901
name: cycloheximide transport
namespace: biological_process
def: "The directed movement of cycloheximide into, out of, within or between cells by means of some external agent such as a transporter or pore. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0042891 ! antibiotic transport

[Term]
id: GO:0015902
name: carbonyl cyanide m-chlorophenylhydrazone transport
namespace: biological_process
def: "The directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [http://cancerweb.ncl.ac.uk/]
synonym: "CCCP transport" EXACT []
is_a: GO:0015893 ! drug transport

[Term]
id: GO:0015903
name: fluconazole transport
namespace: biological_process
def: "The directed movement of fluconazole into, out of, within or between cells by means of some external agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [http://cancerweb.ncl.ac.uk/]
is_a: GO:0015850 ! organic alcohol transport
is_a: GO:0045117 ! azole transport

[Term]
id: GO:0015904
name: tetracycline transport
namespace: biological_process
def: "The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "tetracyclin transport" EXACT []
is_a: GO:0015850 ! organic alcohol transport
is_a: GO:0042891 ! antibiotic transport

[Term]
id: GO:0015905
name: bicyclomycin transport
namespace: biological_process
def: "The directed movement of bicyclomycin into, out of, within or between cells by means of some external agent such as a transporter or pore. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [ISBN:91191028X]
subset: gosubset_prok
is_a: GO:0042891 ! antibiotic transport

[Term]
id: GO:0015906
name: sulfathiazole transport
namespace: biological_process
def: "The directed movement of sulfathiazole into, out of, within or between cells by means of some external agent such as a transporter or pore. Sulfathiazole is an antibacterial agent of the sulfonamide group." [http://cancerweb.ncl.ac.uk/]
synonym: "sulphathiazole transport" EXACT []
is_a: GO:0045117 ! azole transport

[Term]
id: GO:0015908
name: fatty acid transport
namespace: biological_process
def: "The directed movement of fatty acids into, out of, within or between cells by means of some external agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006869 ! lipid transport
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0015909
name: long-chain fatty acid transport
namespace: biological_process
def: "The directed movement of long-chain fatty acids into, out of, within or between cells by means of some external agent such as a transporter or pore. A long-chain fatty acid is an aliphatic compound with a terminal carboxyl group and with a chain length greater than C12." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015908 ! fatty acid transport

[Term]
id: GO:0015910
name: peroxisomal long-chain fatty acid import
namespace: biological_process
def: "The directed movement of long-chain fatty acids into a peroxisome." [GOC:ai]
synonym: "peroxisomal long-chain fatty acid uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015909 ! long-chain fatty acid transport

[Term]
id: GO:0015911
name: plasma membrane long-chain fatty acid transport
namespace: biological_process
def: "The directed movement of long-chain fatty acids across the plasma membrane." [GOC:ai]
is_a: GO:0015909 ! long-chain fatty acid transport

[Term]
id: GO:0015912
name: short-chain fatty acid transport
namespace: biological_process
def: "The directed movement of short-chain fatty acids into, out of, within or between cells by means of some external agent such as a transporter or pore. Short-chain fatty acids are fatty acids with a chain length of less than 8 carbons." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015908 ! fatty acid transport

[Term]
id: GO:0015913
name: short-chain fatty acid import
namespace: biological_process
def: "The directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than 8 carbons." [GOC:ai]
synonym: "short-chain fatty acid uptake" EXACT []
is_a: GO:0015912 ! short-chain fatty acid transport

[Term]
id: GO:0015914
name: phospholipid transport
namespace: biological_process
def: "The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006869 ! lipid transport

[Term]
id: GO:0015915
name: fatty acyl transport
namespace: biological_process
def: "The directed movement of fatty acyl groups into, out of, within or between cells by means of some external agent such as a transporter or pore. A fatty acyl group is any acyl group derived from a fatty acid." [GOC:ai]
is_a: GO:0006869 ! lipid transport

[Term]
id: GO:0015916
name: fatty acyl coenzyme A transport
namespace: biological_process
def: "The directed movement of fatty acyl coenzyme A into, out of, within or between cells by means of some external agent such as a transporter or pore. Fatty acyl coenzyme A is an acyl group linked to 3'-phosphoadenosine-(5')diphospho(4')pantatheine (coenzyme A)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0015915 ! fatty acyl transport

[Term]
id: GO:0015917
name: aminophospholipid transport
namespace: biological_process
def: "The directed movement of aminophospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:ai]
is_a: GO:0006869 ! lipid transport

[Term]
id: GO:0015918
name: sterol transport
namespace: biological_process
def: "The directed movement of sterols into, out of, within or between cells by means of some external agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai]
xref: Reactome:265473 "Trafficking of dietary sterols"
xref: Reactome:448619 "Trafficking of dietary sterols"
xref: Reactome:469747 "Trafficking of dietary sterols"
xref: Reactome:487454 "Trafficking of dietary sterols"
xref: Reactome:507411 "Trafficking of dietary sterols"
xref: Reactome:517847 "Trafficking of dietary sterols"
xref: Reactome:526681 "Trafficking of dietary sterols"
xref: Reactome:531453 "Trafficking of dietary sterols"
xref: Reactome:536839 "Trafficking of dietary sterols"
xref: Reactome:542593 "Trafficking of dietary sterols"
xref: Reactome:558114 "Trafficking of dietary sterols"
xref: Reactome:568742 "Trafficking of dietary sterols"
xref: Reactome:581945 "Trafficking of dietary sterols"
xref: Reactome:585989 "Trafficking of dietary sterols"
xref: Reactome:592848 "Trafficking of dietary sterols"
is_a: GO:0006869 ! lipid transport

[Term]
id: GO:0015919
name: peroxisomal membrane transport
namespace: biological_process
def: "The directed movement of substances to, from or across the peroxisomal membrane." [GOC:ai]
is_a: GO:0043574 ! peroxisomal transport

[Term]
id: GO:0015920
name: lipopolysaccharide transport
namespace: biological_process
def: "The directed movement of lipopolysaccharides into, out of, within or between cells by means of some external agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "LPS transport" EXACT []
is_a: GO:0015774 ! polysaccharide transport

[Term]
id: GO:0015921
name: lipopolysaccharide export
namespace: biological_process
def: "The directed movement of lipopolysaccharides out of a cell or organelle." [GOC:ai]
subset: gosubset_prok
synonym: "LPS export" EXACT []
is_a: GO:0015920 ! lipopolysaccharide transport

[Term]
id: GO:0015922
name: aspartate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2." [EC:1.4.3.1, EC:1.4.3.16]
subset: gosubset_prok
xref: EC:1.4.3.-
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0015923
name: mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative." [GOC:ai]
subset: gosubset_prok
xref: EC:3.2.1.-
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015924
name: mannosyl-oligosaccharide mannosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides." [EC:3.2.1.-, GOC:ai]
subset: gosubset_prok
xref: EC:3.2.1.-
is_a: GO:0015923 ! mannosidase activity

[Term]
id: GO:0015925
name: galactosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." [GOC:ai]
subset: gosubset_prok
xref: EC:3.2.1.-
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015926
name: glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: EC:3.2.1.-
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015927
name: trehalase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of trehalose or a trehalose derivative." [GOC:ai]
subset: gosubset_prok
xref: EC:3.2.1.-
xref: MetaCyc:TREHALA-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015928
name: fucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative." [GOC:ai]
subset: gosubset_prok
xref: EC:3.2.1.-
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015929
name: hexosaminidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides." [http://www.onelook.com/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
xref: EC:3.2.1.-
xref: MetaCyc:3.2.1.52-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0015930
name: glutamate synthase activity
namespace: molecular_function
def: "Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors." [EC:1.4.-.-]
subset: gosubset_prok
xref: EC:1.4.-.-
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0015931
name: nucleobase, nucleoside, nucleotide and nucleic acid transport
namespace: biological_process
def: "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0015932
name: nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0015933
name: flavin-containing electron transporter
namespace: molecular_function
def: "OBSOLETE. An oxidoreductase which contains either flavin-adenine dinucleotide or flavin mononucleotide as a prosthetic group, utilizes either NADH or NADPH and transfers electrons to other electron transfer proteins." [GOC:kd]
comment: This term was made obsolete because it does not describe a molecular function.
is_obsolete: true
replaced_by: GO:0009055

[Term]
id: GO:0015934
name: large ribosomal subunit
namespace: cellular_component
def: "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ribosomal large subunit" EXACT []
is_a: GO:0033279 ! ribosomal subunit

[Term]
id: GO:0015935
name: small ribosomal subunit
namespace: cellular_component
def: "The smaller of the two subunits of a ribosome." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "ribosomal small subunit" EXACT []
is_a: GO:0033279 ! ribosomal subunit

[Term]
id: GO:0015936
name: coenzyme A metabolic process
namespace: biological_process
alt_id: GO:0006763
def: "The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]
subset: gosubset_prok
synonym: "CoA metabolism" EXACT []
synonym: "coenzyme A metabolism" EXACT []
is_a: GO:0006752 ! group transfer coenzyme metabolic process
is_a: GO:0033865 ! nucleoside bisphosphate metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0015937
name: coenzyme A biosynthetic process
namespace: biological_process
alt_id: GO:0006764
def: "The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]
subset: gosubset_prok
synonym: "CoA biosynthesis" EXACT []
synonym: "coenzyme A anabolism" EXACT []
synonym: "coenzyme A biosynthesis" EXACT []
synonym: "coenzyme A formation" EXACT []
synonym: "coenzyme A synthesis" EXACT []
xref: MetaCyc:COA-PWY
xref: MetaCyc:PANTOSYN-PWY
xref: MetaCyc:PWY-4221
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0015936 ! coenzyme A metabolic process

[Term]
id: GO:0015938
name: coenzyme A catabolic process
namespace: biological_process
alt_id: GO:0006765
def: "The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684]
subset: gosubset_prok
synonym: "CoA catabolism" EXACT []
synonym: "coenzyme A breakdown" EXACT []
synonym: "coenzyme A catabolism" EXACT []
synonym: "coenzyme A degradation" EXACT []
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0015936 ! coenzyme A metabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0015939
name: pantothenate metabolic process
namespace: biological_process
alt_id: GO:0006770
def: "The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "pantothenate metabolism" EXACT []
synonym: "vitamin B5 metabolic process" EXACT []
synonym: "vitamin B5 metabolism" EXACT []
xref: Reactome:199220 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:448763 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:469878 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:487795 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:507538 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:517521 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:526390 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:531201 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:536576 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:542302 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:547643 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:552235 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:557848 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:568442 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:581655 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:585806 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:592567 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:595455 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:597441 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:598136 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:599779 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:600697 "Vitamin B5 (pantothenate) metabolism"
xref: Reactome:602610 "Vitamin B5 (pantothenate) metabolism"
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0006752 ! group transfer coenzyme metabolic process

[Term]
id: GO:0015940
name: pantothenate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "pantothenate anabolism" EXACT []
synonym: "pantothenate biosynthesis" EXACT []
synonym: "pantothenate formation" EXACT []
synonym: "pantothenate synthesis" EXACT []
synonym: "vitamin B5 biosynthesis" EXACT []
synonym: "vitamin B5 biosynthetic process" EXACT []
xref: MetaCyc:PANTOSYN-PWY
xref: MetaCyc:PWY-4221
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0015939 ! pantothenate metabolic process
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process

[Term]
id: GO:0015941
name: pantothenate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "pantothenate breakdown" EXACT []
synonym: "pantothenate catabolism" EXACT []
synonym: "pantothenate degradation" EXACT []
synonym: "vitamin B5 catabolic process" EXACT []
synonym: "vitamin B5 catabolism" EXACT []
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0015939 ! pantothenate metabolic process
is_a: GO:0042219 ! cellular amino acid derivative catabolic process

[Term]
id: GO:0015942
name: formate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "formate metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0015943
name: formate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "formate anabolism" EXACT []
synonym: "formate biosynthesis" EXACT []
synonym: "formate formation" EXACT []
synonym: "formate synthesis" EXACT []
synonym: "formic acid biosynthesis" EXACT []
synonym: "formic acid biosynthetic process" EXACT []
is_a: GO:0015942 ! formate metabolic process

[Term]
id: GO:0015944
name: formate oxidation
namespace: biological_process
def: "The chemical reactions and pathways by which formate is converted to CO2." [MetaCyc:PWY-1881]
subset: gosubset_prok
synonym: "formic acid oxidation" EXACT []
xref: MetaCyc:PWY-1881
is_a: GO:0015942 ! formate metabolic process

[Term]
id: GO:0015945
name: methanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "methanol metabolism" EXACT []
is_a: GO:0034308 ! monohydric alcohol metabolic process

[Term]
id: GO:0015946
name: methanol oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M." [MetaCyc:CO2FORM-PWY]
subset: gosubset_prok
xref: MetaCyc:CO2FORM-PWY
is_a: GO:0015945 ! methanol metabolic process

[Term]
id: GO:0015947
name: methane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "methane metabolism" EXACT []
is_a: GO:0043446 ! cellular alkane metabolic process

[Term]
id: GO:0015948
name: methanogenesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "methane biosynthesis" EXACT []
synonym: "methane biosynthetic process" EXACT []
xref: UM-BBD_pathwayID:meth
xref: Wikipedia:Methanogenesis
is_a: GO:0009061 ! anaerobic respiration
is_a: GO:0015947 ! methane metabolic process
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds
is_a: GO:0043447 ! alkane biosynthetic process

[Term]
id: GO:0015949
name: nucleobase, nucleoside and nucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide is synthesized from another nucleobase, nucleoside or nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: goslim_pir
subset: gosubset_prok
xref: MetaCyc:P1-PWY
is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process

[Term]
id: GO:0015950
name: purine nucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a purine nucleotide is synthesized from another purine nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0015949 ! nucleobase, nucleoside and nucleotide interconversion

[Term]
id: GO:0015951
name: purine ribonucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a purine ribonucleotide is synthesized from another purine ribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0015950 ! purine nucleotide interconversion

[Term]
id: GO:0015952
name: purine deoxyribonucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a purine deoxyribonucleotide is synthesized from another purine deoxyribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0015950 ! purine nucleotide interconversion

[Term]
id: GO:0015953
name: pyrimidine nucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a pyrimidine nucleotide is synthesized from another pyrimidine nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0015949 ! nucleobase, nucleoside and nucleotide interconversion

[Term]
id: GO:0015954
name: pyrimidine ribonucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a pyrimidine ribonucleotide is synthesized from another pyrimidine ribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0015953 ! pyrimidine nucleotide interconversion

[Term]
id: GO:0015955
name: pyrimidine deoxyribonucleotide interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a pyrimidine deoxyribonucleotide is synthesized from another pyrimidine deoxyribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0015953 ! pyrimidine nucleotide interconversion

[Term]
id: GO:0015956
name: bis(5'-nucleosidyl) oligophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777]
subset: gosubset_prok
synonym: "bis(5'-nucleosidyl) oligophosphate metabolism" EXACT []
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0015957
name: bis(5'-nucleosidyl) oligophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777]
subset: gosubset_prok
synonym: "bis(5'-nucleosidyl) oligophosphate anabolism" EXACT []
synonym: "bis(5'-nucleosidyl) oligophosphate biosynthesis" EXACT []
synonym: "bis(5'-nucleosidyl) oligophosphate formation" EXACT []
synonym: "bis(5'-nucleosidyl) oligophosphate synthesis" EXACT []
is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0015958
name: bis(5'-nucleosidyl) oligophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777]
subset: gosubset_prok
synonym: "bis(5'-nucleosidyl) oligophosphate breakdown" EXACT []
synonym: "bis(5'-nucleosidyl) oligophosphate catabolism" EXACT []
synonym: "bis(5'-nucleosidyl) oligophosphate degradation" EXACT []
is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process

[Term]
id: GO:0015959
name: diadenosine polyphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine polyphosphate metabolism" EXACT []
is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process

[Term]
id: GO:0015960
name: diadenosine polyphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine polyphosphate anabolism" EXACT []
synonym: "diadenosine polyphosphate biosynthesis" EXACT []
synonym: "diadenosine polyphosphate formation" EXACT []
synonym: "diadenosine polyphosphate synthesis" EXACT []
is_a: GO:0015957 ! bis(5'-nucleosidyl) oligophosphate biosynthetic process
is_a: GO:0015959 ! diadenosine polyphosphate metabolic process

[Term]
id: GO:0015961
name: diadenosine polyphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine polyphosphate breakdown" EXACT []
synonym: "diadenosine polyphosphate catabolism" EXACT []
synonym: "diadenosine polyphosphate degradation" EXACT []
is_a: GO:0015958 ! bis(5'-nucleosidyl) oligophosphate catabolic process
is_a: GO:0015959 ! diadenosine polyphosphate metabolic process

[Term]
id: GO:0015962
name: diadenosine triphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine triphosphate metabolism" EXACT []
is_a: GO:0015959 ! diadenosine polyphosphate metabolic process

[Term]
id: GO:0015963
name: diadenosine triphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine triphosphate anabolism" EXACT []
synonym: "diadenosine triphosphate biosynthesis" EXACT []
synonym: "diadenosine triphosphate formation" EXACT []
synonym: "diadenosine triphosphate synthesis" EXACT []
is_a: GO:0015960 ! diadenosine polyphosphate biosynthetic process
is_a: GO:0015962 ! diadenosine triphosphate metabolic process

[Term]
id: GO:0015964
name: diadenosine triphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine triphosphate breakdown" EXACT []
synonym: "diadenosine triphosphate catabolism" EXACT []
synonym: "diadenosine triphosphate degradation" EXACT []
is_a: GO:0015961 ! diadenosine polyphosphate catabolic process
is_a: GO:0015962 ! diadenosine triphosphate metabolic process

[Term]
id: GO:0015965
name: diadenosine tetraphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine tetraphosphate metabolism" EXACT []
is_a: GO:0015959 ! diadenosine polyphosphate metabolic process

[Term]
id: GO:0015966
name: diadenosine tetraphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine tetraphosphate anabolism" EXACT []
synonym: "diadenosine tetraphosphate biosynthesis" EXACT []
synonym: "diadenosine tetraphosphate formation" EXACT []
synonym: "diadenosine tetraphosphate synthesis" EXACT []
is_a: GO:0015960 ! diadenosine polyphosphate biosynthetic process
is_a: GO:0015965 ! diadenosine tetraphosphate metabolic process

[Term]
id: GO:0015967
name: diadenosine tetraphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai]
subset: gosubset_prok
synonym: "diadenosine tetraphosphate breakdown" EXACT []
synonym: "diadenosine tetraphosphate catabolism" EXACT []
synonym: "diadenosine tetraphosphate degradation" EXACT []
is_a: GO:0015961 ! diadenosine polyphosphate catabolic process
is_a: GO:0015965 ! diadenosine tetraphosphate metabolic process

[Term]
id: GO:0015968
name: stringent response
namespace: biological_process
def: "A specific global change in the metabolism of a bacterial cell (the downregulation of nucleic acid and protein synthesis, and the simultaneous upregulation of protein degradation and amino acid synthesis) as a result of starvation." [GOC:jl, ISBN:0124325653, PMID:11282471]
subset: gosubset_prok
xref: Wikipedia:Stringent_response
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0015969
name: guanosine tetraphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai]
subset: gosubset_prok
synonym: "guanosine tetraphosphate (5'-ppGpp-3') metabolic process" EXACT []
synonym: "guanosine tetraphosphate (5'-ppGpp-3') metabolism" EXACT []
synonym: "guanosine tetraphosphate metabolism" EXACT []
xref: MetaCyc:PPGPPMET-PWY
is_a: GO:0008617 ! guanosine metabolic process
is_a: GO:0033865 ! nucleoside bisphosphate metabolic process

[Term]
id: GO:0015970
name: guanosine tetraphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai]
subset: gosubset_prok
synonym: "guanosine tetraphosphate (5'-ppGpp-3') biosynthesis" EXACT []
synonym: "guanosine tetraphosphate (5'-ppGpp-3') biosynthetic process" EXACT []
synonym: "guanosine tetraphosphate anabolism" EXACT []
synonym: "guanosine tetraphosphate biosynthesis" EXACT []
synonym: "guanosine tetraphosphate formation" EXACT []
synonym: "guanosine tetraphosphate synthesis" EXACT []
is_a: GO:0015969 ! guanosine tetraphosphate metabolic process
is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process
is_a: GO:0046114 ! guanosine biosynthetic process

[Term]
id: GO:0015971
name: guanosine tetraphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai]
subset: gosubset_prok
synonym: "guanosine tetraphosphate (5'-ppGpp-3') catabolic process" EXACT []
synonym: "guanosine tetraphosphate (5'-ppGpp-3') catabolism" EXACT []
synonym: "guanosine tetraphosphate breakdown" EXACT []
synonym: "guanosine tetraphosphate catabolism" EXACT []
synonym: "guanosine tetraphosphate degradation" EXACT []
is_a: GO:0015969 ! guanosine tetraphosphate metabolic process
is_a: GO:0046115 ! guanosine catabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0015972
name: guanosine pentaphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai]
subset: gosubset_prok
synonym: "guanosine pentaphosphate (5'-pppGpp-3') metabolic process" EXACT []
synonym: "guanosine pentaphosphate (5'-pppGpp-3') metabolism" EXACT []
synonym: "guanosine pentaphosphate metabolism" EXACT []
is_a: GO:0008617 ! guanosine metabolic process

[Term]
id: GO:0015973
name: guanosine pentaphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai]
subset: gosubset_prok
synonym: "guanosine pentaphosphate (5'-pppGpp-3') biosynthesis" EXACT []
synonym: "guanosine pentaphosphate (5'-pppGpp-3') biosynthetic process" EXACT []
synonym: "guanosine pentaphosphate anabolism" EXACT []
synonym: "guanosine pentaphosphate biosynthesis" EXACT []
synonym: "guanosine pentaphosphate formation" EXACT []
synonym: "guanosine pentaphosphate synthesis" EXACT []
is_a: GO:0015972 ! guanosine pentaphosphate metabolic process
is_a: GO:0046114 ! guanosine biosynthetic process

[Term]
id: GO:0015974
name: guanosine pentaphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai]
subset: gosubset_prok
synonym: "guanosine pentaphosphate (5'-pppGpp-3') catabolic process" EXACT []
synonym: "guanosine pentaphosphate (5'-pppGpp-3') catabolism" EXACT []
synonym: "guanosine pentaphosphate breakdown" EXACT []
synonym: "guanosine pentaphosphate catabolism" EXACT []
synonym: "guanosine pentaphosphate degradation" EXACT []
is_a: GO:0015972 ! guanosine pentaphosphate metabolic process
is_a: GO:0046115 ! guanosine catabolic process

[Term]
id: GO:0015975
name: energy derivation by oxidation of reduced inorganic compounds
namespace: biological_process
def: "The chemical reactions and pathways by which a cell derives energy from inorganic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah]
subset: gosubset_prok
synonym: "chemolithotrophie" EXACT []
synonym: "chemolithotrophy" EXACT []
synonym: "lithotrophy" EXACT [Wikipedia:Lithotrophy]
xref: Wikipedia:Lithotrophy
is_a: GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0015976
name: carbon utilization
namespace: biological_process
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0015977
name: carbon utilization by fixation of carbon dioxide
namespace: biological_process
def: "Any process by which inorganic carbon (usually carbon dioxide) is incorporated into organic compounds (usually carbohydrates)." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "autotrophic CO2 fixation" EXACT []
synonym: "autotrophic CO2 fixation pathway" EXACT []
synonym: "autotrophy" EXACT []
xref: Wikipedia:Autotrophy
is_a: GO:0015976 ! carbon utilization

[Term]
id: GO:0015978
name: carbon utilization by utilization of organic compounds
namespace: biological_process
subset: gosubset_prok
synonym: "heterotrophy" EXACT []
xref: Wikipedia:Heterotroph
is_a: GO:0015976 ! carbon utilization

[Term]
id: GO:0015979
name: photosynthesis
namespace: biological_process
def: "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684]
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
xref: Wikipedia:Photosynthesis
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0015980
name: energy derivation by oxidation of organic compounds
namespace: biological_process
def: "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah]
subset: gosubset_prok
synonym: "chemoorganotrophy" EXACT []
is_a: GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0015981
name: passive proton transport, down the electrochemical gradient
namespace: biological_process
def: "OBSOLETE. The passive movement of protons from areas of high proton concentration and electrical potential to areas where concentration and electrical potential are low." [ISBN:0716731363]
comment: This term was made obsolete because it represents a passive process which occurs without the aid of gene products.
is_obsolete: true
consider: GO:0015992

[Term]
id: GO:0015982
name: antiport
namespace: biological_process
def: "OBSOLETE. The process of coupled solute translocation in which two solutes equilibrate across an osmotic barrier, the translocation of solute being coupled to the translocation of the other in the opposite direction." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
is_obsolete: true
replaced_by: GO:0015297

[Term]
id: GO:0015983
name: symport
namespace: biological_process
def: "OBSOLETE. The process of solute translocation in which two solutes equilibrate across an osmotic barrier, and the translocation of one solute is coupled to the translocation of the other in the same direction." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
is_obsolete: true
replaced_by: GO:0015293

[Term]
id: GO:0015984
name: uniport
namespace: biological_process
def: "OBSOLETE. The process of noncoupled solute translocation or facilitated diffusion." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a molecular function rather than a biological process.
is_obsolete: true
replaced_by: GO:0015292

[Term]
id: GO:0015985
name: energy coupled proton transport, down electrochemical gradient
namespace: biological_process
def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP." [GOC:mah]
subset: gosubset_prok
is_a: GO:0015992 ! proton transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0015986
name: ATP synthesis coupled proton transport
namespace: biological_process
def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363]
subset: gosubset_prok
is_a: GO:0006754 ! ATP biosynthetic process
is_a: GO:0015985 ! energy coupled proton transport, down electrochemical gradient
relationship: part_of GO:0006119 ! oxidative phosphorylation

[Term]
id: GO:0015987
name: GTP synthesis coupled proton transport
namespace: biological_process
def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers GTP synthesis." [ISBN:0716731363]
is_a: GO:0015985 ! energy coupled proton transport, down electrochemical gradient

[Term]
id: GO:0015988
name: energy coupled proton transport, against electrochemical gradient
namespace: biological_process
def: "The transport of protons against an electrochemical gradient, using energy from a source such as ATP hydrolysis, light, or electron transport." [GOC:mah]
subset: gosubset_prok
is_a: GO:0015992 ! proton transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0015989
name: light-driven proton transport
namespace: biological_process
def: "The transport of protons against an electrochemical gradient, using energy from light." [GOC:mah]
is_a: GO:0015988 ! energy coupled proton transport, against electrochemical gradient

[Term]
id: GO:0015990
name: electron transport coupled proton transport
namespace: biological_process
def: "The transport of protons against an electrochemical gradient, using energy from electron transport." [GOC:mah]
is_a: GO:0015988 ! energy coupled proton transport, against electrochemical gradient

[Term]
id: GO:0015991
name: ATP hydrolysis coupled proton transport
namespace: biological_process
def: "The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah]
subset: gosubset_prok
is_a: GO:0015988 ! energy coupled proton transport, against electrochemical gradient

[Term]
id: GO:0015992
name: proton transport
namespace: biological_process
def: "The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl]
subset: gosubset_prok
synonym: "hydrogen ion transport" EXACT []
synonym: "passive proton transport, down the electrochemical gradient" NARROW []
xref: Reactome:166187 "Mitochondrial Uncoupling Proteins"
xref: Reactome:167827 "The proton buffering model"
xref: Reactome:449089 "Mitochondrial Uncoupling Proteins"
xref: Reactome:449267 "The proton buffering model"
xref: Reactome:470201 "Mitochondrial Uncoupling Proteins"
xref: Reactome:470387 "The proton buffering model"
xref: Reactome:487888 "Mitochondrial Uncoupling Proteins"
xref: Reactome:488064 "The proton buffering model"
xref: Reactome:507859 "Mitochondrial Uncoupling Proteins"
xref: Reactome:508026 "The proton buffering model"
xref: Reactome:568683 "Mitochondrial Uncoupling Proteins"
xref: Reactome:568763 "The proton buffering model"
xref: Reactome:581886 "Mitochondrial Uncoupling Proteins"
xref: Reactome:581966 "The proton buffering model"
is_a: GO:0006818 ! hydrogen transport
is_a: GO:0015672 ! monovalent inorganic cation transport

[Term]
id: GO:0015993
name: molecular hydrogen transport
namespace: biological_process
def: "The directed movement of molecular hydrogen (H2) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl]
is_a: GO:0006818 ! hydrogen transport

[Term]
id: GO:0015994
name: chlorophyll metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl]
subset: gosubset_prok
synonym: "chlorophyll metabolism" EXACT []
is_a: GO:0006778 ! porphyrin metabolic process

[Term]
id: GO:0015995
name: chlorophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [GOC:jl]
subset: gosubset_prok
synonym: "chlorophyll anabolism" EXACT []
synonym: "chlorophyll biosynthesis" EXACT []
synonym: "chlorophyll formation" EXACT []
synonym: "chlorophyll synthesis" EXACT []
xref: MetaCyc:CHLOROPHYLL-SYN
is_a: GO:0006779 ! porphyrin biosynthetic process
is_a: GO:0015994 ! chlorophyll metabolic process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0015996
name: chlorophyll catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, into less complex products." [GOC:jl]
subset: gosubset_prok
synonym: "chlorophyll breakdown" EXACT []
synonym: "chlorophyll catabolism" EXACT []
synonym: "chlorophyll degradation" EXACT []
is_a: GO:0006787 ! porphyrin catabolic process
is_a: GO:0015994 ! chlorophyll metabolic process
is_a: GO:0046149 ! pigment catabolic process

[Term]
id: GO:0015997
name: ubiquinone biosynthetic process monooxygenase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it incorporates biological process information.
synonym: "coenzyme Q biosynthesis monooxygenase activity" EXACT []
synonym: "coenzyme Q biosynthetic process monooxygenase activity" EXACT []
synonym: "ubiquinone anabolism monooxygenase activity" EXACT []
synonym: "ubiquinone formation monooxygenase activity" EXACT []
synonym: "ubiquinone synthesis monooxygenase activity" EXACT []
is_obsolete: true

[Term]
id: GO:0016002
name: sulfite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2S + acceptor + 3 H2O = SO3(2-) (sulfite) + reduced acceptor." [EC:1.8.99.1]
subset: gosubset_prok
synonym: "assimilatory sulfite reductase activity" EXACT [EC:1.8.99.1]
synonym: "assimilatory-type sulfite reductase activity" EXACT [EC:1.8.99.1]
synonym: "hydrogen-sulfide:(acceptor) oxidoreductase activity" EXACT [EC:1.8.99.1]
synonym: "hydrogen-sulfide:acceptor oxidoreductase activity" EXACT [EC:1.8.99.1]
synonym: "siroheme sulfite reductase activity" NARROW [MetaCyc:SULFITE-REDUCTASE-RXN]
synonym: "sulphite reductase activity" EXACT []
xref: EC:1.8.99.1
xref: MetaCyc:SULFITE-REDUCTASE-RXN
is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors

[Term]
id: GO:0016004
name: phospholipase activator activity
namespace: molecular_function
def: "Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai]
is_a: GO:0060229 ! lipase activator activity

[Term]
id: GO:0016005
name: phospholipase A2 activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme phospholipase A2." [GOC:ai]
is_a: GO:0016004 ! phospholipase activator activity

[Term]
id: GO:0016006
name: Nebenkern
namespace: cellular_component
def: "A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma]
is_a: GO:0005739 ! mitochondrion

[Term]
id: GO:0016007
name: mitochondrial derivative
namespace: cellular_component
def: "The major and minor mitochondrial derivatives are the mitochondria of the sperm tail and derive by the unfolding of the Nebenkern during flagellum elongation." [GOC:ma]
is_a: GO:0005739 ! mitochondrion

[Term]
id: GO:0016008
name: major mitochondrial derivative
namespace: cellular_component
def: "The larger of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation; the major mitochondrial derivative is ovoid and darker than the minor derivative." [GOC:mah, PMID:17123504]
is_a: GO:0016007 ! mitochondrial derivative

[Term]
id: GO:0016009
name: minor mitochondrial derivative
namespace: cellular_component
def: "The smaller of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation." [GOC:mah, PMID:17123504]
is_a: GO:0016007 ! mitochondrial derivative

[Term]
id: GO:0016010
name: dystrophin-associated glycoprotein complex
namespace: cellular_component
def: "A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609]
subset: goslim_pir
synonym: "DGC" EXACT []
synonym: "dystrophin glycoprotein complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0016011
name: dystroglycan complex
namespace: cellular_component
def: "A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin." [PMID:15117830, PMID:16710609]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex

[Term]
id: GO:0016012
name: sarcoglycan complex
namespace: cellular_component
def: "A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609]
synonym: "sarcoglycan-sarcospan complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0016011 ! dystroglycan complex

[Term]
id: GO:0016013
name: syntrophin complex
namespace: cellular_component
def: "A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase." [http://www.dmd.nl/DGC.html#syn]
synonym: "nitric oxide synthase-dystrophin complex, skeletal muscle" RELATED [CORUM:416]
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex

[Term]
id: GO:0016014
name: dystrobrevin complex
namespace: cellular_component
def: "A protein complex comprising alpha- and beta-dystrobrevin; forms part of the dystrophin glycoprotein complex." [PMID:15117830, PMID:16710609]
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex

[Term]
id: GO:0016015
name: morphogen activity
namespace: molecular_function
is_a: GO:0004871 ! signal transducer activity

[Term]
id: GO:0016016
name: short-wave-sensitive opsin
namespace: molecular_function
def: "OBSOLETE. An opsin with maximal absorption between 400 and 500 nm." [PMID:10594055]
comment: This term was made obsolete because it refers to a class of proteins.
is_obsolete: true
consider: GO:0007603
consider: GO:0009588
consider: GO:0009881
consider: GO:0016021
consider: GO:0016918
consider: GO:0046876

[Term]
id: GO:0016018
name: cyclosporin A binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids." [GOC:mb]
synonym: "cyclophilin" RELATED []
is_a: GO:0008144 ! drug binding
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0016019
name: peptidoglycan receptor activity
namespace: molecular_function
def: "Combining with a peptidoglycan to initiate a change in cell activity." [PMID:14698226]
comment: Note that only peptidoglycan recognition proteins with receptor activity should be annotated to this term; otherwise use 'peptidoglycan binding ; GO:0042834' instead.
synonym: "peptidoglycan recognition activity" NARROW []
is_a: GO:0008329 ! pattern recognition receptor activity
is_a: GO:0042834 ! peptidoglycan binding

[Term]
id: GO:0016020
name: membrane
namespace: cellular_component
def: "Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:mah, ISBN:0815316194]
subset: goslim_candida
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Biological_membrane
is_a: GO:0044464 ! cell part

[Term]
id: GO:0016021
name: integral to membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane." [GOC:go_curators]
subset: gosubset_prok
synonym: "transmembrane" RELATED [GOC:mah]
xref: Wikipedia:Transmembrane_protein
is_a: GO:0031224 ! intrinsic to membrane

[Term]
id: GO:0016023
name: cytoplasmic membrane-bounded vesicle
namespace: cellular_component
def: "A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_yeast
subset: gosubset_prok
synonym: "cytoplasmic membrane bounded vesicle" EXACT []
synonym: "cytoplasmic membrane-enclosed vesicle" EXACT []
is_a: GO:0031410 ! cytoplasmic vesicle
is_a: GO:0031988 ! membrane-bounded vesicle
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0016024
name: CDP-diacylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "CDP-diacylglycerol anabolism" EXACT []
synonym: "CDP-diacylglycerol biosynthesis" EXACT []
synonym: "CDP-diacylglycerol formation" EXACT []
synonym: "CDP-diacylglycerol synthesis" EXACT []
is_a: GO:0006651 ! diacylglycerol biosynthetic process
is_a: GO:0046341 ! CDP-diacylglycerol metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0016025
name: proteasome endopeptidase regulator
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
consider: GO:0004175

[Term]
id: GO:0016026
name: proteasome endopeptidase core
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
consider: GO:0004175

[Term]
id: GO:0016027
name: inaD signaling complex
namespace: cellular_component
def: "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [FB:FBrf0105321, GOC:hb, PMID:9010208]
synonym: "inaD signalling complex" EXACT []
is_a: GO:0019897 ! extrinsic to plasma membrane
is_a: GO:0043234 ! protein complex
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0016028 ! rhabdomere

[Term]
id: GO:0016028
name: rhabdomere
namespace: cellular_component
def: "The specialized microvillar organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, PMID:8646774]
subset: goslim_pir
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0016029
name: subrhabdomeral cisterna
namespace: cellular_component
def: "A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase." [PMID:11707492, PMID:8646774]
synonym: "SMC" RELATED []
synonym: "submicrovillar cisterna" EXACT [PMID:11707492]
is_a: GO:0031984 ! organelle subcompartment
is_a: GO:0044432 ! endoplasmic reticulum part
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0005790 ! smooth endoplasmic reticulum
relationship: part_of GO:0016028 ! rhabdomere

[Term]
id: GO:0016030
name: metarhodopsin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with metarhodopsin, a transient intermediate produced upon irradiation of rhodopsin in the visual cycle and existing in two forms, metarhodopsins I and II. The latter dissociates to form opsin and all-trans retinal." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0002046 ! opsin binding

[Term]
id: GO:0016031
name: cytoplasmic tRNA import into mitochondrion
namespace: biological_process
def: "The directed movement of cytoplasmic tRNA into a mitochondrion." [GOC:ma, PMID:10988073, PMID:11121736]
synonym: "cytoplasmic tRNA import into mitochondria" EXACT []
synonym: "cytoplasmic tRNA transport into mitochondrion" EXACT []
synonym: "cytoplasmic tRNA, mitochondrial import" EXACT []
synonym: "mitochondrial import of cytoplasmic tRNA" EXACT []
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0051031 ! tRNA transport

[Term]
id: GO:0016032
name: viral reproduction
namespace: biological_process
def: "The process by which a virus reproduces. Usually, this is by infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:mah]
comment: See also the biological process terms 'viral infectious cycle ; GO:0019058' and 'lysogeny ; GO:0030069'.
subset: goslim_generic
subset: goslim_pir
synonym: "viral infection" RELATED []
synonym: "viral life cycle" EXACT []
synonym: "viral replication cycle" EXACT []
synonym: "virulence" RELATED []
xref: Reactome:162587 "HIV Life Cycle"
xref: Reactome:162906 "HIV Infection"
xref: Reactome:168255 "Influenza Life Cycle"
xref: Wikipedia:Viral_life_cycle
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0016034
name: maleylacetoacetate isomerase activity
namespace: molecular_function
alt_id: GO:0018841
def: "Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate." [EC:5.2.1.2]
subset: gosubset_prok
synonym: "4-maleylacetoacetate cis-trans-isomerase activity" EXACT [EC:5.2.1.2]
synonym: "maleylacetoacetic isomerase activity" EXACT [EC:5.2.1.2]
synonym: "maleylacetone cis-trans-isomerase activity" EXACT [EC:5.2.1.2]
synonym: "maleylacetone isomerase activity" EXACT [EC:5.2.1.2]
xref: EC:5.2.1.2
xref: MetaCyc:MALEYLACETOACETATE-ISOMERASE-RXN
xref: Reactome:23371 "maleylacetoacetate isomerase activity"
xref: UM-BBD_enzymeID:e0082
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0016035
name: zeta DNA polymerase complex
namespace: cellular_component
def: "A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer." [PMID:16631579, PMID:16971464]
is_a: GO:0042575 ! DNA polymerase complex
is_a: GO:0044446 ! intracellular organelle part

[Term]
id: GO:0016036
name: cellular response to phosphate starvation
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate." [GOC:jl]
subset: gosubset_prok
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0016037
name: absorption of light
namespace: biological_process
def: "The reception of a photon by a cell." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0009583 ! detection of light stimulus

[Term]
id: GO:0016038
name: absorption of visible light
namespace: biological_process
def: "The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0016037 ! absorption of light

[Term]
id: GO:0016039
name: absorption of UV light
namespace: biological_process
def: "The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0016037 ! absorption of light

[Term]
id: GO:0016040
name: glutamate synthase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-glutamate + NAD+ = L-glutamine + 2-oxoglutarate + NADH + H+." [EC:1.4.1.14]
subset: gosubset_prok
synonym: "glutamate (reduced nicotinamide adenine dinucleotide) synthase" EXACT [EC:1.4.1.14]
synonym: "L-glutamate synthase (NADH)" EXACT [EC:1.4.1.14]
synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.14]
synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.14]
synonym: "L-glutamate:NAD+ oxidoreductase (transaminating)" EXACT [EC:1.4.1.14]
synonym: "NADH-dependent glutamate synthase activity" EXACT [EC:1.4.1.14]
synonym: "NADH-glutamate synthase activity" EXACT [EC:1.4.1.14]
synonym: "NADH: GOGAT" RELATED [EC:1.4.1.14]
xref: EC:1.4.1.14
xref: MetaCyc:GLUTAMATE-SYNTHASE-NADH-RXN
is_a: GO:0045181 ! glutamate synthase activity, NADH or NADPH as acceptor

[Term]
id: GO:0016041
name: glutamate synthase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+." [EC:1.4.7.1]
subset: gosubset_prok
synonym: "ferredoxin-dependent glutamate synthase activity" EXACT [EC:1.4.7.1]
synonym: "ferredoxin-glutamate synthase activity" EXACT [EC:1.4.7.1]
synonym: "glutamate synthase (ferredoxin-dependent)" EXACT [EC:1.4.7.1]
synonym: "L-glutamate:ferredoxin oxidoreductase (transaminating)" EXACT [EC:1.4.7.1]
xref: EC:1.4.7.1
xref: MetaCyc:GLUTAMATE-SYNTHASE-FERREDOXIN-RXN
xref: MetaCyc:PWY-4341
is_a: GO:0015930 ! glutamate synthase activity
is_a: GO:0016643 ! oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0016042
name: lipid catabolic process
namespace: biological_process
alt_id: GO:0006724
def: "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators]
subset: gosubset_prok
synonym: "lipid breakdown" EXACT []
synonym: "lipid catabolism" EXACT []
synonym: "lipid degradation" EXACT []
synonym: "lipolysis" EXACT []
xref: Wikipedia:Lipid_catabolism
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0009056 ! catabolic process

[Term]
id: GO:0016043
name: cellular component organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cell organisation" EXACT []
synonym: "cell organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0016044
name: cellular membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "membrane organisation" EXACT [GOC:curators]
synonym: "membrane organization and biogenesis" RELATED [GOC:mah]
xref: Reactome:199991 "Membrane Trafficking"
xref: Reactome:448815 "Membrane Trafficking"
xref: Reactome:469931 "Membrane Trafficking"
xref: Reactome:487634 "Membrane Trafficking"
xref: Reactome:507593 "Membrane Trafficking"
xref: Reactome:517561 "Membrane Trafficking"
xref: Reactome:526427 "Membrane Trafficking"
xref: Reactome:531244 "Membrane Trafficking"
xref: Reactome:536615 "Membrane Trafficking"
xref: Reactome:542339 "Membrane Trafficking"
xref: Reactome:547680 "Membrane Trafficking"
xref: Reactome:552334 "Membrane Trafficking"
xref: Reactome:557889 "Membrane Trafficking"
xref: Reactome:568487 "Membrane Trafficking"
xref: Reactome:581698 "Membrane Trafficking"
xref: Reactome:585888 "Membrane Trafficking"
xref: Reactome:592605 "Membrane Trafficking"
xref: Reactome:595446 "Membrane Trafficking"
is_a: GO:0009987 ! cellular process
is_a: GO:0061024 ! membrane organization

[Term]
id: GO:0016045
name: detection of bacterium
namespace: biological_process
alt_id: GO:0009598
alt_id: GO:0009681
def: "The series of events in which a stimulus from a bacterium is received and converted into a molecular signal." [GOC:hb]
synonym: "detection of bacteria" EXACT []
synonym: "perception of bacteria" RELATED []
synonym: "perception of bacterium" RELATED []
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009595 ! detection of biotic stimulus
is_a: GO:0009617 ! response to bacterium

[Term]
id: GO:0016046
name: detection of fungus
namespace: biological_process
alt_id: GO:0009599
def: "The series of events in which a stimulus from a fungus is received and converted into a molecular signal." [GOC:hb]
synonym: "detection of fungi" EXACT []
synonym: "perception of fungi" RELATED []
synonym: "perception of fungus" RELATED []
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009595 ! detection of biotic stimulus
is_a: GO:0009620 ! response to fungus

[Term]
id: GO:0016047
name: detection of parasitic fungus
namespace: biological_process
def: "The series of events in which a stimulus from a parasitic fungus (a fungus which spends all or part of its life in or on another organism from which it obtains nourishment and/or protection) is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "detection of parasitic fungi" EXACT []
synonym: "perception of parasitic fungi" RELATED []
synonym: "perception of parasitic fungus" RELATED []
is_a: GO:0009603 ! detection of symbiotic fungus
is_a: GO:0009623 ! response to parasitic fungus

[Term]
id: GO:0016048
name: detection of temperature stimulus
namespace: biological_process
def: "The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal." [GOC:hb]
synonym: "detection of temperature" EXACT []
synonym: "detection of thermal stimulus" EXACT []
synonym: "perception of temperature" RELATED []
is_a: GO:0009266 ! response to temperature stimulus
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus

[Term]
id: GO:0016049
name: cell growth
namespace: biological_process
def: "The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cell expansion" RELATED []
synonym: "cellular growth" EXACT []
synonym: "growth of cell" EXACT []
synonym: "metabolic process resulting in cell growth" RELATED []
synonym: "metabolism resulting in cell growth" RELATED []
is_a: GO:0009987 ! cellular process
is_a: GO:0040007 ! growth
relationship: part_of GO:0008361 ! regulation of cell size

[Term]
id: GO:0016050
name: vesicle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah]
subset: goslim_pir
subset: goslim_yeast
synonym: "vesicle organisation" EXACT [GOC:curators]
synonym: "vesicle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0016051
name: carbohydrate biosynthetic process
namespace: biological_process
alt_id: GO:0006093
def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "anabolic carbohydrate metabolic process" EXACT []
synonym: "anabolic carbohydrate metabolism" EXACT []
synonym: "carbohydrate anabolism" EXACT []
synonym: "carbohydrate biosynthesis" EXACT []
synonym: "carbohydrate formation" EXACT []
synonym: "carbohydrate synthesis" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0016052
name: carbohydrate catabolic process
namespace: biological_process
alt_id: GO:0006095
def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "carbohydrate breakdown" EXACT []
synonym: "carbohydrate catabolism" EXACT []
synonym: "carbohydrate degradation" EXACT []
synonym: "catabolic carbohydrate metabolic process" EXACT []
synonym: "catabolic carbohydrate metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0009056 ! catabolic process

[Term]
id: GO:0016053
name: organic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "organic acid anabolism" EXACT []
synonym: "organic acid biosynthesis" EXACT []
synonym: "organic acid formation" EXACT []
synonym: "organic acid synthesis" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process

[Term]
id: GO:0016054
name: organic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "organic acid breakdown" EXACT []
synonym: "organic acid catabolism" EXACT []
synonym: "organic acid degradation" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044282 ! small molecule catabolic process

[Term]
id: GO:0016055
name: Wnt receptor signaling pathway
namespace: biological_process
alt_id: GO:0007222
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397]
synonym: "frizzled signaling pathway" EXACT []
synonym: "frizzled signalling pathway" EXACT []
synonym: "Wg signaling pathway" EXACT [GOC:sart, PMID:8080429]
synonym: "Wg signalling pathway" EXACT [GOC:sart, PMID:8080429]
synonym: "Wingless signaling pathway" EXACT [GOC:sart, PMID:8080429]
synonym: "Wingless signalling pathway" EXACT [GOC:sart, PMID:8080429]
synonym: "Wnt receptor signalling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor linked signaling pathway
is_a: GO:0023034 ! intracellular signaling pathway

[Term]
id: GO:0016056
name: rhodopsin mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon." [GOC:dph, GOC:hb, GOC:tb]
synonym: "rhodopsin mediated signalling pathway" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0016057
name: regulation of membrane potential in photoreceptor cell
namespace: biological_process
def: "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb]
synonym: "changes in polarization state of photoreceptor cell membrane" EXACT [GOC:dph, GOC:tb]
is_a: GO:0042391 ! regulation of membrane potential
relationship: part_of GO:0016056 ! rhodopsin mediated signaling pathway

[Term]
id: GO:0016058
name: maintenance of membrane potential in photoreceptor cell by rhodopsin mediated signaling
namespace: biological_process
def: "Maintenance of the excited state of a photoreceptor cell to produce a steady state current as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb]
synonym: "maintenance of rhodopsin mediated signaling" RELATED []
synonym: "maintenance of rhodopsin mediated signalling" EXACT []
is_a: GO:0016057 ! regulation of membrane potential in photoreceptor cell

[Term]
id: GO:0016059
name: deactivation of rhodopsin mediated signaling
namespace: biological_process
def: "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831]
synonym: "deactivation of rhodopsin mediated signalling" EXACT []
is_a: GO:0022400 ! regulation of rhodopsin mediated signaling pathway
relationship: part_of GO:0009586 ! rhodopsin mediated phototransduction

[Term]
id: GO:0016060
name: metarhodopsin inactivation
namespace: biological_process
def: "Process by which metarhodopsin is prevented from generating molecular signals." [GOC:hb]
is_a: GO:0009968 ! negative regulation of signal transduction
relationship: part_of GO:0016059 ! deactivation of rhodopsin mediated signaling

[Term]
id: GO:0016061
name: regulation of light-activated channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of light-activated channel activity." [GOC:go_curators]
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity

[Term]
id: GO:0016062
name: adaptation of rhodopsin mediated signaling
namespace: biological_process
def: "Process by which the visual system can modulate its sensitivity and response to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation." [PMID:1962207]
synonym: "adaptation of rhodopsin mediated signalling" EXACT []
is_a: GO:0023058 ! adaptation of signaling pathway
relationship: part_of GO:0009586 ! rhodopsin mediated phototransduction

[Term]
id: GO:0016063
name: rhodopsin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "rhodopsin anabolism" EXACT []
synonym: "rhodopsin biosynthesis" EXACT []
synonym: "rhodopsin formation" EXACT []
synonym: "rhodopsin synthesis" EXACT []
is_a: GO:0006726 ! eye pigment biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0046154 ! rhodopsin metabolic process

[Term]
id: GO:0016064
name: immunoglobulin mediated immune response
namespace: biological_process
def: "An immune response mediated by immunoglobulins, whether cell-bound or in solution." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was improved by GO_REF:0000022. It was renamed and redefined.
synonym: "antibody-mediated immune response" EXACT []
is_a: GO:0019724 ! B cell mediated immunity

[Term]
id: GO:0016065
name: humoral defense mechanism (sensu Protostomia)
namespace: biological_process
def: "OBSOLETE. The specific immune response mediated by antibodies. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317)." [GOC:add, GOC:jic]
comment: This term was made obsolete because antibodies are not found in the taxon Protostomia.
synonym: "humoral defence mechanism (sensu Protostomia)" EXACT []
is_obsolete: true

[Term]
id: GO:0016068
name: type I hypersensitivity
namespace: biological_process
def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity.
synonym: "immediate hypersensitivity response" EXACT []
xref: Wikipedia:Type_I_hypersensitivity
is_a: GO:0002524 ! hypersensitivity
is_a: GO:0016064 ! immunoglobulin mediated immune response

[Term]
id: GO:0016070
name: RNA metabolic process
namespace: biological_process
def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "RNA metabolism" EXACT []
is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0016071
name: mRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pombe
subset: gosubset_prok
synonym: "mRNA metabolism" EXACT []
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0016072
name: rRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "rRNA metabolism" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0016073
name: snRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "snRNA metabolism" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0016074
name: snoRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA." [GOC:krc]
synonym: "snoRNA metabolism" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0016075
name: rRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes." [GOC:ai]
subset: gosubset_prok
synonym: "rRNA breakdown" EXACT []
synonym: "rRNA catabolism" EXACT []
synonym: "rRNA degradation" EXACT []
is_a: GO:0016072 ! rRNA metabolic process
is_a: GO:0034661 ! ncRNA catabolic process

[Term]
id: GO:0016076
name: snRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of snRNA, small nuclear RNA, low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "snRNA breakdown" EXACT []
synonym: "snRNA catabolism" EXACT []
synonym: "snRNA degradation" EXACT []
is_a: GO:0016073 ! snRNA metabolic process
is_a: GO:0034661 ! ncRNA catabolic process

[Term]
id: GO:0016077
name: snoRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "snoRNA breakdown" EXACT []
synonym: "snoRNA catabolism" EXACT []
synonym: "snoRNA degradation" EXACT []
is_a: GO:0016074 ! snoRNA metabolic process
is_a: GO:0034661 ! ncRNA catabolic process

[Term]
id: GO:0016078
name: tRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis." [GOC:ai]
subset: gosubset_prok
synonym: "tRNA breakdown" EXACT []
synonym: "tRNA catabolism" EXACT []
synonym: "tRNA degradation" EXACT []
is_a: GO:0006399 ! tRNA metabolic process
is_a: GO:0034661 ! ncRNA catabolic process

[Term]
id: GO:0016079
name: synaptic vesicle exocytosis
namespace: biological_process
def: "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jic, GOC:lmg]
is_a: GO:0006887 ! exocytosis
is_a: GO:0048489 ! synaptic vesicle transport
relationship: part_of GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0016080
name: synaptic vesicle targeting
namespace: biological_process
def: "The process by which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:mah]
is_a: GO:0006903 ! vesicle targeting
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0016081
name: synaptic vesicle docking during exocytosis
namespace: biological_process
def: "The initial attachment of a synaptic vesicle membrane to the presynaptic membrane, mediated by proteins protruding from the membrane of the synaptic vesicle and the target membrane." [PMID:15217342]
is_a: GO:0006904 ! vesicle docking during exocytosis
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0016082
name: synaptic vesicle priming
namespace: biological_process
def: "The formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:mah, PMID:15217342]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0016083
name: synaptic vesicle fusion
namespace: biological_process
def: "OBSOLETE. Fusion of the synaptic vesicle with the postsynaptic membrane." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/]
comment: This term was made obsolete because it was wrongly defined.
is_obsolete: true
consider: GO:0016192

[Term]
id: GO:0016084
name: myostimulatory hormone activity
namespace: molecular_function
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0016085
name: myoinhibitory hormone activity
namespace: molecular_function
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0016086
name: allatostatin
namespace: molecular_function
def: "OBSOLETE. Peptide hormones produced by the corpora allata of insects that reversibly inhibit the production of juvenile hormone." [GOC:ai, http://cancerweb.ncl.ac.uk/, PMID:10891383]
comment: This term was made obsolete because it refers to a gene product.
is_obsolete: true
consider: GO:0005102
consider: GO:0045968

[Term]
id: GO:0016087
name: ecdysiostatic hormone activity
namespace: molecular_function
is_a: GO:0005184 ! neuropeptide hormone activity

[Term]
id: GO:0016088
name: insulin
namespace: molecular_function
def: "OBSOLETE. A polypeptide hormone that stimulates glucose uptake by muscle and adipose tissue, and promotes glycogenesis, lipogenesis and the synthesis of proteins and nucleic acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0005102
consider: GO:0045722
consider: GO:0045727
consider: GO:0045935
consider: GO:0046326
consider: GO:0046889

[Term]
id: GO:0016090
name: prenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [ISBN:0198547684]
subset: gosubset_prok
synonym: "prenol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0016091
name: prenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [GOC:go_curators]
subset: gosubset_prok
synonym: "prenol anabolism" EXACT []
synonym: "prenol biosynthesis" EXACT []
synonym: "prenol formation" EXACT []
synonym: "prenol synthesis" EXACT []
is_a: GO:0008299 ! isoprenoid biosynthetic process
is_a: GO:0016090 ! prenol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0016092
name: prenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [GOC:go_curators]
subset: gosubset_prok
synonym: "prenol breakdown" EXACT []
synonym: "prenol catabolism" EXACT []
synonym: "prenol degradation" EXACT []
is_a: GO:0008300 ! isoprenoid catabolic process
is_a: GO:0016090 ! prenol metabolic process

[Term]
id: GO:0016093
name: polyprenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [ISBN:0198547684]
subset: gosubset_prok
synonym: "polyprenol metabolism" EXACT []
is_a: GO:0016090 ! prenol metabolic process

[Term]
id: GO:0016094
name: polyprenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators]
subset: gosubset_prok
synonym: "polyprenol anabolism" EXACT []
synonym: "polyprenol biosynthesis" EXACT []
synonym: "polyprenol formation" EXACT []
synonym: "polyprenol synthesis" EXACT []
is_a: GO:0016091 ! prenol biosynthetic process
is_a: GO:0016093 ! polyprenol metabolic process

[Term]
id: GO:0016095
name: polyprenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators]
subset: gosubset_prok
synonym: "polyprenol breakdown" EXACT []
synonym: "polyprenol catabolism" EXACT []
synonym: "polyprenol degradation" EXACT []
is_a: GO:0016092 ! prenol catabolic process
is_a: GO:0016093 ! polyprenol metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0016098
name: monoterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton." [ChEBI:25409, ISBN:0198547684]
subset: gosubset_prok
synonym: "monoterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0016099
name: monoterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton." [ChEBI:25409]
subset: gosubset_prok
synonym: "monoterpenoid anabolism" EXACT []
synonym: "monoterpenoid biosynthesis" EXACT []
synonym: "monoterpenoid formation" EXACT []
synonym: "monoterpenoid synthesis" EXACT []
xref: MetaCyc:PWY-3041
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016100
name: monoterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monoterpenoid compounds, terpenoids having a C10 skeleton." [ChEBI:25409]
subset: gosubset_prok
synonym: "monoterpenoid breakdown" EXACT []
synonym: "monoterpenoid catabolism" EXACT []
synonym: "monoterpenoid degradation" EXACT []
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016101
name: diterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units." [ISBN:0198547684]
subset: gosubset_prok
synonym: "diterpene metabolic process" NARROW []
synonym: "diterpene metabolism" NARROW []
synonym: "diterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0016102
name: diterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "diterpene biosynthesis" NARROW []
synonym: "diterpene biosynthetic process" NARROW []
synonym: "diterpenoid anabolism" EXACT []
synonym: "diterpenoid biosynthesis" EXACT []
synonym: "diterpenoid formation" EXACT []
synonym: "diterpenoid synthesis" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016103
name: diterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diterpenoid compounds, terpenoids with four isoprene units." [GOC:mah, ISBN:0198547684]
subset: gosubset_prok
synonym: "diterpene catabolic process" NARROW []
synonym: "diterpene catabolism" NARROW []
synonym: "diterpenoid breakdown" EXACT []
synonym: "diterpenoid catabolism" EXACT []
synonym: "diterpenoid degradation" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016104
name: triterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units." [GOC:go_curators]
subset: gosubset_prok
synonym: "triterpene biosynthesis" NARROW []
synonym: "triterpene biosynthetic process" NARROW []
synonym: "triterpenoid anabolism" EXACT []
synonym: "triterpenoid biosynthesis" EXACT []
synonym: "triterpenoid formation" EXACT []
synonym: "triterpenoid synthesis" EXACT []
is_a: GO:0006722 ! triterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016105
name: triterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of triterpenoid compounds, terpenoids with six isoprene units." [GOC:go_curators]
subset: gosubset_prok
synonym: "triterpene catabolic process" NARROW []
synonym: "triterpene catabolism" NARROW []
synonym: "triterpenoid breakdown" EXACT []
synonym: "triterpenoid catabolism" EXACT []
synonym: "triterpenoid degradation" EXACT []
is_a: GO:0006722 ! triterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016106
name: sesquiterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators]
subset: gosubset_prok
synonym: "sesquiterpenoid anabolism" EXACT []
synonym: "sesquiterpenoid biosynthesis" EXACT []
synonym: "sesquiterpenoid formation" EXACT []
synonym: "sesquiterpenoid synthesis" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0051762 ! sesquiterpene biosynthetic process

[Term]
id: GO:0016107
name: sesquiterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators]
subset: gosubset_prok
synonym: "sesquiterpenoid breakdown" EXACT []
synonym: "sesquiterpenoid catabolism" EXACT []
synonym: "sesquiterpenoid degradation" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process
is_a: GO:0051763 ! sesquiterpene catabolic process

[Term]
id: GO:0016108
name: tetraterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetraterpenoid compounds, terpenoids with eight isoprene units." [ISBN:0198547684]
subset: gosubset_prok
synonym: "tetraterpene metabolic process" NARROW []
synonym: "tetraterpene metabolism" NARROW []
synonym: "tetraterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0016109
name: tetraterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators]
subset: gosubset_prok
synonym: "tetraterpene biosynthesis" NARROW []
synonym: "tetraterpene biosynthetic process" NARROW []
synonym: "tetraterpenoid anabolism" EXACT []
synonym: "tetraterpenoid biosynthesis" EXACT []
synonym: "tetraterpenoid formation" EXACT []
synonym: "tetraterpenoid synthesis" EXACT []
is_a: GO:0016108 ! tetraterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016110
name: tetraterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators]
subset: gosubset_prok
synonym: "tetraterpene catabolic process" NARROW []
synonym: "tetraterpene catabolism" NARROW []
synonym: "tetraterpenoid breakdown" EXACT []
synonym: "tetraterpenoid catabolism" EXACT []
synonym: "tetraterpenoid degradation" EXACT []
is_a: GO:0016108 ! tetraterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016111
name: polyterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polyterpenoid compounds, terpenoids with more than eight isoprene units." [ISBN:0198547684]
subset: gosubset_prok
synonym: "polyterpene metabolic process" NARROW []
synonym: "polyterpene metabolism" NARROW []
synonym: "polyterpenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0016112
name: polyterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators]
subset: gosubset_prok
synonym: "polyterpene biosynthesis" NARROW []
synonym: "polyterpene biosynthetic process" NARROW []
synonym: "polyterpenoid anabolism" EXACT []
synonym: "polyterpenoid biosynthesis" EXACT []
synonym: "polyterpenoid formation" EXACT []
synonym: "polyterpenoid synthesis" EXACT []
is_a: GO:0016111 ! polyterpenoid metabolic process
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0016113
name: polyterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators]
subset: gosubset_prok
synonym: "polyterpene catabolic process" NARROW []
synonym: "polyterpene catabolism" NARROW []
synonym: "polyterpenoid breakdown" EXACT []
synonym: "polyterpenoid catabolism" EXACT []
synonym: "polyterpenoid degradation" EXACT []
is_a: GO:0016111 ! polyterpenoid metabolic process
is_a: GO:0016115 ! terpenoid catabolic process

[Term]
id: GO:0016114
name: terpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai]
subset: gosubset_prok
synonym: "terpenoid anabolism" EXACT []
synonym: "terpenoid biosynthesis" EXACT []
synonym: "terpenoid formation" EXACT []
synonym: "terpenoid synthesis" EXACT []
xref: Wikipedia:Terpenoid
is_a: GO:0006721 ! terpenoid metabolic process
is_a: GO:0008299 ! isoprenoid biosynthetic process

[Term]
id: GO:0016115
name: terpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai]
subset: gosubset_prok
synonym: "terpenoid breakdown" EXACT []
synonym: "terpenoid catabolism" EXACT []
synonym: "terpenoid degradation" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process
is_a: GO:0008300 ! isoprenoid catabolic process

[Term]
id: GO:0016116
name: carotenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [ISBN:0198547684]
subset: gosubset_prok
synonym: "carotenoid metabolism" EXACT []
is_a: GO:0016108 ! tetraterpenoid metabolic process

[Term]
id: GO:0016117
name: carotenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators]
subset: gosubset_prok
synonym: "carotenoid anabolism" EXACT []
synonym: "carotenoid biosynthesis" EXACT []
synonym: "carotenoid formation" EXACT []
synonym: "carotenoid synthesis" EXACT []
xref: MetaCyc:CAROTENOID-PWY
is_a: GO:0016109 ! tetraterpenoid biosynthetic process
is_a: GO:0016116 ! carotenoid metabolic process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0016118
name: carotenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators]
subset: gosubset_prok
synonym: "carotenoid breakdown" EXACT []
synonym: "carotenoid catabolism" EXACT []
synonym: "carotenoid degradation" EXACT []
is_a: GO:0016110 ! tetraterpenoid catabolic process
is_a: GO:0016116 ! carotenoid metabolic process

[Term]
id: GO:0016119
name: carotene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids." [ISBN:0198547684]
subset: gosubset_prok
synonym: "carotene metabolism" EXACT []
is_a: GO:0016116 ! carotenoid metabolic process
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:0016120
name: carotene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carotenes, hydrocarbon carotenoids." [GOC:go_curators]
subset: gosubset_prok
synonym: "carotene anabolism" EXACT []
synonym: "carotene biosynthesis" EXACT []
synonym: "carotene formation" EXACT []
synonym: "carotene synthesis" EXACT []
is_a: GO:0016117 ! carotenoid biosynthetic process
is_a: GO:0016119 ! carotene metabolic process
is_a: GO:0046246 ! terpene biosynthetic process

[Term]
id: GO:0016121
name: carotene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids." [GOC:go_curators]
subset: gosubset_prok
synonym: "carotene breakdown" EXACT []
synonym: "carotene catabolism" EXACT []
synonym: "carotene degradation" EXACT []
is_a: GO:0016118 ! carotenoid catabolic process
is_a: GO:0016119 ! carotene metabolic process
is_a: GO:0046247 ! terpene catabolic process

[Term]
id: GO:0016122
name: xanthophyll metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xanthophylls, oxygen-containing carotenoids." [ISBN:0198547684]
subset: gosubset_prok
synonym: "xanthophyll metabolism" EXACT []
is_a: GO:0016116 ! carotenoid metabolic process

[Term]
id: GO:0016123
name: xanthophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators]
subset: gosubset_prok
synonym: "xanthophyll anabolism" EXACT []
synonym: "xanthophyll biosynthesis" EXACT []
synonym: "xanthophyll formation" EXACT []
synonym: "xanthophyll synthesis" EXACT []
is_a: GO:0016117 ! carotenoid biosynthetic process
is_a: GO:0016122 ! xanthophyll metabolic process

[Term]
id: GO:0016124
name: xanthophyll catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators]
subset: gosubset_prok
synonym: "xanthophyll breakdown" EXACT []
synonym: "xanthophyll catabolism" EXACT []
synonym: "xanthophyll degradation" EXACT []
is_a: GO:0016118 ! carotenoid catabolic process
is_a: GO:0016122 ! xanthophyll metabolic process

[Term]
id: GO:0016125
name: sterol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]
subset: gosubset_prok
synonym: "sterol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0008202 ! steroid metabolic process

[Term]
id: GO:0016126
name: sterol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]
subset: gosubset_prok
synonym: "sterol anabolism" EXACT []
synonym: "sterol biosynthesis" EXACT []
synonym: "sterol formation" EXACT []
synonym: "sterol synthesis" EXACT []
xref: MetaCyc:PWY-2541
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0016125 ! sterol metabolic process

[Term]
id: GO:0016127
name: sterol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]
subset: gosubset_prok
synonym: "sterol breakdown" EXACT []
synonym: "sterol catabolism" EXACT []
synonym: "sterol degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0016125 ! sterol metabolic process

[Term]
id: GO:0016128
name: phytosteroid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytosteroids, steroids of higher plants differing from animal steroids C1 or C2 residues at C24 and/or a double bond at C22." [ISBN:0198547684]
subset: gosubset_prok
synonym: "phytosteroid metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process

[Term]
id: GO:0016129
name: phytosteroid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytosteroids, steroids of higher plants differing from animal steroids in having substitutions at C24 and/or a double bond at C22." [GOC:go_curators, ISBN:0471331309 "Biochemical Pathways"]
subset: gosubset_prok
synonym: "phytosteroid anabolism" EXACT []
synonym: "phytosteroid biosynthesis" EXACT []
synonym: "phytosteroid formation" EXACT []
synonym: "phytosteroid synthesis" EXACT []
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0016128 ! phytosteroid metabolic process

[Term]
id: GO:0016130
name: phytosteroid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phytosteroids, steroids of higher plants differing from animal steroids C1 or C2 residues at C24 and/or a double bond at C22." [GOC:go_curators]
subset: gosubset_prok
synonym: "phytosteroid breakdown" EXACT []
synonym: "phytosteroid catabolism" EXACT []
synonym: "phytosteroid degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0016128 ! phytosteroid metabolic process

[Term]
id: GO:0016131
name: brassinosteroid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023]
subset: gosubset_prok
synonym: "brassinosteroid metabolism" EXACT []
is_a: GO:0016128 ! phytosteroid metabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0016132
name: brassinosteroid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023]
subset: gosubset_prok
synonym: "brassinosteroid anabolism" EXACT []
synonym: "brassinosteroid biosynthesis" EXACT []
synonym: "brassinosteroid formation" EXACT []
synonym: "brassinosteroid synthesis" EXACT []
xref: MetaCyc:PWY-2582
xref: MetaCyc:PWY-699
is_a: GO:0016129 ! phytosteroid biosynthetic process
is_a: GO:0016131 ! brassinosteroid metabolic process
is_a: GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0016133
name: brassinosteroid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023]
subset: gosubset_prok
synonym: "brassinosteroid breakdown" EXACT []
synonym: "brassinosteroid catabolism" EXACT []
synonym: "brassinosteroid degradation" EXACT []
is_a: GO:0016130 ! phytosteroid catabolic process
is_a: GO:0016131 ! brassinosteroid metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0016134
name: saponin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving saponins, glycosides of plants in which the aglycan (sapogenin) moiety is a terpene or steroid and the sugar moiety is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [ISBN:0198547684]
subset: gosubset_prok
synonym: "saponin metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process
is_a: GO:0016128 ! phytosteroid metabolic process
is_a: GO:0016137 ! glycoside metabolic process

[Term]
id: GO:0016135
name: saponin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of saponins, glycosides of plants in which the aglycan (sapogenin) moiety is a terpene or steroid and the sugar moiety is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators]
subset: gosubset_prok
synonym: "saponin anabolism" EXACT []
synonym: "saponin biosynthesis" EXACT []
synonym: "saponin formation" EXACT []
synonym: "saponin synthesis" EXACT []
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0016129 ! phytosteroid biosynthetic process
is_a: GO:0016134 ! saponin metabolic process
is_a: GO:0016138 ! glycoside biosynthetic process

[Term]
id: GO:0016136
name: saponin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of saponins, glycosides of plants in which the aglycan (sapogenin) moiety is a terpene or steroid and the sugar moiety is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators]
subset: gosubset_prok
synonym: "saponin breakdown" EXACT []
synonym: "saponin catabolism" EXACT []
synonym: "saponin degradation" EXACT []
is_a: GO:0016115 ! terpenoid catabolic process
is_a: GO:0016130 ! phytosteroid catabolic process
is_a: GO:0016134 ! saponin metabolic process
is_a: GO:0016139 ! glycoside catabolic process

[Term]
id: GO:0016137
name: glycoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [ISBN:0198547684]
subset: gosubset_prok
synonym: "glycoside metabolism" EXACT []
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0016138
name: glycoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycoside anabolism" EXACT []
synonym: "glycoside biosynthesis" EXACT []
synonym: "glycoside formation" EXACT []
synonym: "glycoside synthesis" EXACT []
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0034637 ! cellular carbohydrate biosynthetic process

[Term]
id: GO:0016139
name: glycoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycoside breakdown" EXACT []
synonym: "glycoside catabolism" EXACT []
synonym: "glycoside degradation" EXACT []
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process

[Term]
id: GO:0016140
name: O-glycoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving O-glycosides, any compound in which a glycosyl group has been substituted into a hydroxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "O-glycoside metabolism" EXACT []
is_a: GO:0016137 ! glycoside metabolic process

[Term]
id: GO:0016141
name: O-glycoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of O-glycosides, any compound in which a glycosyl group has been substituted into a hydroxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "O-glycoside anabolism" EXACT []
synonym: "O-glycoside biosynthesis" EXACT []
synonym: "O-glycoside formation" EXACT []
synonym: "O-glycoside synthesis" EXACT []
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0016140 ! O-glycoside metabolic process

[Term]
id: GO:0016142
name: O-glycoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of O-glycosides, any compound in which a glycosyl group has been substituted into a hydroxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "O-glycoside breakdown" EXACT []
synonym: "O-glycoside catabolism" EXACT []
synonym: "O-glycoside degradation" EXACT []
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0016140 ! O-glycoside metabolic process

[Term]
id: GO:0016143
name: S-glycoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "S-glycoside metabolism" EXACT []
synonym: "thioglycoside metabolic process" EXACT []
synonym: "thioglycoside metabolism" EXACT []
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0016137 ! glycoside metabolic process

[Term]
id: GO:0016144
name: S-glycoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "S-glycoside anabolism" EXACT []
synonym: "S-glycoside biosynthesis" EXACT []
synonym: "S-glycoside formation" EXACT []
synonym: "S-glycoside synthesis" EXACT []
synonym: "thioglycoside biosynthesis" EXACT []
synonym: "thioglycoside biosynthetic process" EXACT []
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0016143 ! S-glycoside metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0016145
name: S-glycoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "S-glycoside breakdown" EXACT []
synonym: "S-glycoside catabolism" EXACT []
synonym: "S-glycoside degradation" EXACT []
synonym: "thioglycoside catabolic process" EXACT []
synonym: "thioglycoside catabolism" EXACT []
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0016143 ! S-glycoside metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0016146
name: protein-synthesizing GTPase activity, initiation
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48]
comment: This term was made obsolete because it contains both process and function information.
is_obsolete: true
replaced_by: GO:0003743
replaced_by: GO:0003924
replaced_by: GO:0006412
replaced_by: GO:0006413

[Term]
id: GO:0016147
name: protein-synthesizing GTPase activity, elongation
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48]
comment: This term was made obsolete because it contains both process and function information.
is_obsolete: true
replaced_by: GO:0003746
replaced_by: GO:0003924
replaced_by: GO:0006412
replaced_by: GO:0006414

[Term]
id: GO:0016148
name: protein-synthesizing GTPase activity, termination
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48]
comment: This term was made obsolete because it contains both process and function information.
is_obsolete: true
replaced_by: GO:0003924
replaced_by: GO:0006412
replaced_by: GO:0006415
replaced_by: GO:0008079

[Term]
id: GO:0016149
name: translation release factor activity, codon specific
namespace: molecular_function
def: "A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0003747 ! translation release factor activity

[Term]
id: GO:0016150
name: translation release factor activity, codon nonspecific
namespace: molecular_function
def: "A translation release factor that is not specific to particular codons; binds to guanine nucleotides." [ISBN:0198547684]
comment: Consider also annotating to the molecular function term 'GTP binding ; GO:0005525'.
is_a: GO:0003747 ! translation release factor activity

[Term]
id: GO:0016151
name: nickel ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with nickel (Ni) ions." [GOC:ai]
subset: gosubset_prok
synonym: "nickel binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0016152
name: mercury (II) reductase activity
namespace: molecular_function
alt_id: GO:0018692
def: "Catalysis of the reaction: Hg + NADP+ + H+ = Hg2+ + NADPH + H+." [EC:1.16.1.1]
subset: gosubset_prok
synonym: "Hg:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.1]
synonym: "mer A" RELATED [EC:1.16.1.1]
synonym: "mercurate(II) reductase activity" EXACT [EC:1.16.1.1]
synonym: "mercuric ion reductase activity" EXACT [EC:1.16.1.1]
synonym: "mercuric reductase activity" EXACT [EC:1.16.1.1]
synonym: "mercury reductase activity" EXACT [EC:1.16.1.1]
synonym: "mercury(II) reductase activity" EXACT [EC:1.16.1.1]
synonym: "reduced NADP:mercuric ion oxidoreductase activity" EXACT [EC:1.16.1.1]
xref: EC:1.16.1.1
xref: MetaCyc:MERCURY-II-REDUCTASE-RXN
xref: UM-BBD_enzymeID:e0056
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0016153
name: urocanate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,5-dihydro-4-oxo-5-imidazolepropanoate = urocanate + H2O." [EC:4.2.1.49]
subset: gosubset_prok
synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming)" EXACT [EC:4.2.1.49]
synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase activity" EXACT [EC:4.2.1.49]
synonym: "imidazolonepropionate hydrolase activity" EXACT [EC:4.2.1.49]
synonym: "urocanase activity" EXACT [EC:4.2.1.49]
xref: EC:4.2.1.49
xref: MetaCyc:UROCANATE-HYDRATASE-RXN
xref: Reactome:23891 "urocanate hydratase activity"
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0016154
name: pyrimidine-nucleoside phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate." [EC:2.4.2.2]
subset: gosubset_prok
synonym: "Py-NPase activity" EXACT [EC:2.4.2.2]
synonym: "pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.2]
xref: EC:2.4.2.2
xref: MetaCyc:PYRIMIDINE-NUCLEOSIDE-PHOSPHORYLASE-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0016155
name: formyltetrahydrofolate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH + H+." [EC:1.5.1.6]
synonym: "10-formyl tetrahydrofolate:NADP oxidoreductase activity" EXACT [EC:1.5.1.6]
synonym: "10-formyl-H2PtGlu:NADP oxidoreductase activity" EXACT [EC:1.5.1.6]
synonym: "10-formyl-H4folate dehydrogenase activity" EXACT [EC:1.5.1.6]
synonym: "10-formyltetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.6]
synonym: "10-formyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.6]
synonym: "N10-formyltetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.6]
xref: EC:1.5.1.6
xref: MetaCyc:FORMYLTETRAHYDROFOLATE-DEHYDROGENASE-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016156
name: fumarate reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: succinate + NAD+ = fumarate + NADH + H+." [EC:1.3.1.6]
subset: gosubset_prok
synonym: "NADH-dependent fumarate reductase activity" EXACT [EC:1.3.1.6]
synonym: "NADH-fumarate reductase activity" EXACT [EC:1.3.1.6]
synonym: "succinate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.6]
xref: EC:1.3.1.6
xref: MetaCyc:FUMARATE-REDUCTASE-NADH-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016157
name: sucrose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose." [EC:2.4.1.13]
subset: gosubset_prok
synonym: "NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.13]
synonym: "sucrose synthetase activity" EXACT [EC:2.4.1.13]
synonym: "sucrose-UDP glucosyltransferase activity" EXACT [EC:2.4.1.13]
synonym: "sucrose-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.13]
synonym: "UDP-glucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13]
synonym: "UDPglucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13]
synonym: "uridine diphosphoglucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13]
xref: EC:2.4.1.13
xref: MetaCyc:SUCROSE-SYNTHASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0016158
name: 3-phytase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.8]
subset: gosubset_prok
synonym: "1-phytase activity" EXACT [EC:3.1.3.8]
synonym: "myo-inositol-hexakisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.8]
synonym: "myo-inositol-hexaphosphate 3-phosphohydrolase activity" EXACT []
synonym: "phytase activity" BROAD []
synonym: "phytate 1-phosphatase activity" EXACT [EC:3.1.3.8]
synonym: "phytate 3-phosphatase activity" EXACT []
xref: EC:3.1.3.8
xref: MetaCyc:RXN0-1001
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0016159
name: muconolactone delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate." [EC:5.3.3.4]
subset: gosubset_prok
synonym: "5-oxo-4,5-dihydrofuran-2-acetate delta3-delta2-isomerase activity" EXACT [EC:5.3.3.4]
synonym: "muconolactone D-isomerase activity" EXACT []
synonym: "muconolactone isomerase activity" EXACT [EC:5.3.3.4]
xref: EC:5.3.3.4
xref: MetaCyc:MUCONOLACTONE-DELTA-ISOMERASE-RXN
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0016160
name: amylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of amylose or an amylose derivative." [GOC:ai]
subset: gosubset_prok
xref: EC:3.2.1.-
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0016161
name: beta-amylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains." [EC:3.2.1.2]
subset: gosubset_prok
synonym: "1,4-alpha-D-glucan maltohydrolase activity" EXACT [EC:3.2.1.2]
synonym: "beta amylase activity" EXACT [EC:3.2.1.2]
synonym: "glycogenase activity" BROAD [EC:3.2.1.2]
synonym: "saccharogen amylase activity" EXACT [EC:3.2.1.2]
xref: EC:3.2.1.2
xref: MetaCyc:RXN-1827
is_a: GO:0016160 ! amylase activity

[Term]
id: GO:0016162
name: cellulose 1,4-beta-cellobiosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91]
subset: gosubset_prok
synonym: "1,4-beta-cellobiohydrolase activity" EXACT [EC:3.2.1.91]
synonym: "1,4-beta-D-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91]
synonym: "1,4-beta-glucan cellobiosidase activity" EXACT [EC:3.2.1.91]
synonym: "avicelase activity" BROAD [EC:3.2.1.91]
synonym: "beta-1,4-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91]
synonym: "beta-1,4-glucan cellobiosylhydrolase activity" EXACT [EC:3.2.1.91]
synonym: "C1 cellulase activity" EXACT [EC:3.2.1.91]
synonym: "CBH 1" RELATED [EC:3.2.1.91]
synonym: "cellobiohydrolase activity" EXACT [EC:3.2.1.91]
synonym: "cellobiohydrolase I" RELATED [EC:3.2.1.91]
synonym: "cellobiosidase activity" EXACT [EC:3.2.1.91]
synonym: "exo-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.91]
synonym: "exo-beta-1,4-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91]
synonym: "exo-cellobiohydrolase activity" EXACT [EC:3.2.1.91]
synonym: "exocellobiohydrolase activity" EXACT [EC:3.2.1.91]
synonym: "exoglucanase activity" EXACT [EC:3.2.1.91]
xref: EC:3.2.1.91
xref: MetaCyc:3.2.1.91-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0016163
name: nitrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1]
subset: gosubset_prok
synonym: "iron-iron nitrogenase activity" NARROW []
synonym: "molybdenum-iron nitrogenase activity" NARROW []
synonym: "reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) activity" EXACT [EC:1.18.6.1]
synonym: "vanadium-iron nitrogenase activity" NARROW []
xref: EC:1.18.6.1
xref: MetaCyc:NITROGENASE-RXN
xref: UM-BBD_enzymeID:e0395
is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor

[Term]
id: GO:0016164
name: Mo-molybdopterin oxidoreductase activity
namespace: molecular_function
subset: gosubset_prok
synonym: "molybdopterin oxidoreductase activity" EXACT []
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016165
name: lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate." [EC:1.13.11.12]
subset: gosubset_prok
synonym: "carotene oxidase activity" NARROW [EC:1.13.11.12]
synonym: "fat oxidase activity" EXACT [EC:1.13.11.12]
synonym: "linoleate:oxygen 13-oxidoreductase activity" EXACT [EC:1.13.11.12]
synonym: "lionoleate:O2 oxidoreductase activity" EXACT [EC:1.13.11.12]
synonym: "lipoperoxidase activity" EXACT [EC:1.13.11.12]
synonym: "lipoxidase activity" EXACT [EC:1.13.11.12]
synonym: "lipoxydase activity" EXACT [EC:1.13.11.12]
xref: EC:1.13.11.12
xref: MetaCyc:LIPOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0016166
name: phytoene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/terp/carot.html]
subset: gosubset_prok
xref: EC:1.3.-.-
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016167
name: glial cell line-derived neurotrophic factor receptor activity
namespace: molecular_function
is_a: GO:0004896 ! cytokine receptor activity

[Term]
id: GO:0016168
name: chlorophyll binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl]
subset: gosubset_prok
is_a: GO:0046906 ! tetrapyrrole binding

[Term]
id: GO:0016169
name: bacteriochlorophyll c binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria." [ISBN:0192800981]
subset: gosubset_prok
is_a: GO:0042314 ! bacteriochlorophyll binding

[Term]
id: GO:0016170
name: interleukin-15 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-15 receptor." [GOC:ai]
synonym: "IL-15" NARROW []
synonym: "interleukin-15 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0016171
name: cell surface antigen
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
is_obsolete: true

[Term]
id: GO:0016172
name: antifreeze activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the formation of ice crystals in organismal fluid (e.g. blood) at below freezing exogenous temperatures." [GOC:jl]
comment: This term was made obsolete because it refers to a biological process.
is_obsolete: true
consider: GO:0042309
consider: GO:0050825
consider: GO:0050826

[Term]
id: GO:0016173
name: ice nucleation inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the formation of ice crystals." [GOC:ai]
comment: This term was made obsolete because it refers to a biological process.
is_obsolete: true
consider: GO:0042309
consider: GO:0050825
consider: GO:0050826

[Term]
id: GO:0016174
name: NAD(P)H oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + H2O2." [EC:1.6.3.1]
synonym: "dual oxidase activity" RELATED [EC:1.6.3.1]
synonym: "NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.6.3.1]
synonym: "NADPH oxidase" BROAD [EC:1.6.3.1]
synonym: "p138tox" RELATED [EC:1.6.3.1]
synonym: "ThOX activity" NARROW [EC:1.6.3.1]
synonym: "THOX2 activity" NARROW [EC:1.6.3.1]
synonym: "thyroid NADPH oxidase activity" NARROW []
synonym: "thyroid oxidase 2 activity" NARROW [EC:1.6.3.1]
synonym: "thyroid oxidase activity" NARROW [EC:1.6.3.1]
xref: EC:1.6.3.1
is_a: GO:0050664 ! oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor

[Term]
id: GO:0016175
name: superoxide-generating NADPH oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-." [GOC:ai, PMID:10806195]
synonym: "cytochrome B-245" RELATED []
xref: EC:1.6.3.-
is_a: GO:0050664 ! oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor

[Term]
id: GO:0016176
name: superoxide-generating NADPH oxidase activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme superoxide-generating NADPH oxidase." [GOC:ai]
synonym: "neutrophil cytosol factor 2" NARROW []
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0016180
name: snRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule." [GOC:jl]
is_a: GO:0016073 ! snRNA metabolic process
is_a: GO:0034470 ! ncRNA processing

[Term]
id: GO:0016182
name: synaptic vesicle budding from endosome
namespace: biological_process
def: "Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/]
synonym: "endosome to synaptic vesicle budding" RELATED [GOC:mah]
synonym: "synaptic vesicle budding involved in synaptic vesicle exocytosis" EXACT [GOC:mah]
is_a: GO:0016197 ! endosome transport
is_a: GO:0070142 ! synaptic vesicle budding
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0016183
name: synaptic vesicle coating
namespace: biological_process
def: "A protein coat is added to the synaptic vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/]
is_a: GO:0006901 ! vesicle coating
relationship: part_of GO:0016185 ! synaptic vesicle budding from presynaptic membrane

[Term]
id: GO:0016184
name: synaptic vesicle retrieval
namespace: biological_process
def: "OBSOLETE. Return of a vesicle from the postsynaptic membrane to presynaptic membrane." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/]
comment: This term was made obsolete because it was wrongly defined.
is_obsolete: true
consider: GO:0016192

[Term]
id: GO:0016185
name: synaptic vesicle budding from presynaptic membrane
namespace: biological_process
def: "Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle." [GOC:mah, http://cancerweb.ncl.ac.uk, http://www.stedmans.com/]
synonym: "synaptic vesicle budding involved in synaptic vesicle endocytosis" EXACT [GOC:mah]
is_a: GO:0070142 ! synaptic vesicle budding
relationship: part_of GO:0048488 ! synaptic vesicle endocytosis

[Term]
id: GO:0016186
name: synaptic vesicle fission
namespace: biological_process
def: "OBSOLETE. Separation of a synaptic vesicle from the presynaptic membrane." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/]
comment: This term was made obsolete because it was wrongly defined.
is_obsolete: true
consider: GO:0016192

[Term]
id: GO:0016187
name: synaptic vesicle internalization
namespace: biological_process
def: "OBSOLETE. Internalization of the contents of a synaptic vesicle into the postsynaptic membrane following endocytosis." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/]
comment: This term was made obsolete because it was wrongly defined.
is_obsolete: true
consider: GO:0016192

[Term]
id: GO:0016188
name: synaptic vesicle maturation
namespace: biological_process
def: "Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/]
is_a: GO:0016050 ! vesicle organization
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0048488 ! synaptic vesicle endocytosis

[Term]
id: GO:0016189
name: synaptic vesicle to endosome fusion
namespace: biological_process
def: "Fusion of a synaptic vesicle with the membrane of an endosome." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/]
synonym: "synaptic vesicle fusion" BROAD []
is_a: GO:0006944 ! cellular membrane fusion
is_a: GO:0016197 ! endosome transport
is_a: GO:0048284 ! organelle fusion
relationship: part_of GO:0048488 ! synaptic vesicle endocytosis

[Term]
id: GO:0016191
name: synaptic vesicle uncoating
namespace: biological_process
def: "The removal of the protein coat on a synaptic vesicle." [http://cancerweb.ncl.ac.uk, http://www.stedmans.com/]
subset: gosubset_prok
synonym: "synaptic vesicle coat depolymerization" EXACT []
synonym: "synaptic vesicle coat protein depolymerization" EXACT []
is_a: GO:0051261 ! protein depolymerization
relationship: part_of GO:0048488 ! synaptic vesicle endocytosis

[Term]
id: GO:0016192
name: vesicle-mediated transport
namespace: biological_process
alt_id: GO:0006899
def: "The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]
subset: goslim_candida
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "nonselective vesicle transport" NARROW []
synonym: "protein sorting along secretory pathway" RELATED []
synonym: "vesicle trafficking" RELATED []
synonym: "vesicle transport" EXACT []
synonym: "vesicular transport" EXACT [GOC:mah]
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0016197
name: endosome transport
namespace: biological_process
def: "The directed movement of substances into, out of or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0016198
name: axon choice point recognition
namespace: biological_process
def: "The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth." [PMID:10218152]
is_a: GO:0008038 ! neuron recognition
relationship: part_of GO:0007411 ! axon guidance

[Term]
id: GO:0016199
name: axon midline choice point recognition
namespace: biological_process
def: "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]
is_a: GO:0016198 ! axon choice point recognition

[Term]
id: GO:0016200
name: synaptic target attraction
namespace: biological_process
def: "The process by which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets." [GOC:mah, ISBN:0878932437]
is_a: GO:0050918 ! positive chemotaxis
relationship: part_of GO:0008039 ! synaptic target recognition

[Term]
id: GO:0016201
name: synaptic target inhibition
namespace: biological_process
def: "The process by which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437]
is_a: GO:0050919 ! negative chemotaxis
relationship: part_of GO:0008039 ! synaptic target recognition

[Term]
id: GO:0016202
name: regulation of striated muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators]
is_a: GO:0048634 ! regulation of muscle organ development
relationship: regulates GO:0014706 ! striated muscle tissue development

[Term]
id: GO:0016203
name: muscle attachment
namespace: biological_process
def: "The developmental process by which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0060538 ! skeletal muscle organ development

[Term]
id: GO:0016204
name: determination of muscle attachment site
namespace: biological_process
def: "The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete]
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0016203 ! muscle attachment

[Term]
id: GO:0016205
name: selenocysteine methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine." [EC:2.1.1.-, PMID:10026151]
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0016206
name: catechol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol." [EC:2.1.1.6]
subset: gosubset_prok
synonym: "catechol methyltransferase activity" EXACT [EC:2.1.1.6]
synonym: "catecholamine O-methyltransferase activity" EXACT [EC:2.1.1.6]
synonym: "COMT I" RELATED [EC:2.1.1.6]
synonym: "COMT II" RELATED [EC:2.1.1.6]
synonym: "MB-COMT (membrane-bound form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6]
synonym: "S-adenosyl-L-methionine:catechol O-methyltransferase activity" EXACT [EC:2.1.1.6]
synonym: "S-COMT (soluble form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6]
xref: EC:2.1.1.6
xref: MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN
xref: Reactome:24294 "catechol O-methyltransferase activity"
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016207
name: 4-coumarate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA." [EC:6.2.1.12]
subset: gosubset_prok
synonym: "4-coumarate-CoA synthetase activity" EXACT []
synonym: "4-coumarate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.12]
synonym: "4-coumarate:CoA ligase activity" EXACT []
synonym: "4-coumarate:coenzyme A ligase activity" EXACT [EC:6.2.1.12]
synonym: "4-coumaroyl-CoA synthase activity" EXACT [EC:6.2.1.12]
synonym: "4-coumaroyl-CoA synthetase activity" EXACT [EC:6.2.1.12]
synonym: "4-coumaryl-CoA synthetase activity" EXACT [EC:6.2.1.12]
synonym: "4CL" RELATED [EC:6.2.1.12]
synonym: "caffeolyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12]
synonym: "feruloyl CoA ligase activity" EXACT [EC:6.2.1.12]
synonym: "feruloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12]
synonym: "hydroxycinnamate:CoA ligase activity" EXACT [EC:6.2.1.12]
synonym: "hydroxycinnamoyl CoA synthetase activity" EXACT [EC:6.2.1.12]
synonym: "p-coumaroyl CoA ligase activity" EXACT [EC:6.2.1.12]
synonym: "p-coumaryl coenzyme A synthetase activity" EXACT [EC:6.2.1.12]
synonym: "p-coumaryl-CoA ligase activity" EXACT [EC:6.2.1.12]
synonym: "p-coumaryl-CoA synthetase activity" EXACT [EC:6.2.1.12]
synonym: "p-hydroxycinnamic acid:CoA ligase activity" EXACT [EC:6.2.1.12]
synonym: "p-hydroxycinnamoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12]
synonym: "sinapoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12]
xref: EC:6.2.1.12
xref: MetaCyc:4-COUMARATE--COA-LIGASE-RXN
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0016208
name: AMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with AMP, adenosine monophosphate." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0032559 ! adenyl ribonucleotide binding

[Term]
id: GO:0016209
name: antioxidant activity
namespace: molecular_function
def: "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016210
name: naringenin-chalcone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2." [EC:2.3.1.74]
subset: gosubset_prok
synonym: "chalcone synthase activity" EXACT [EC:2.3.1.74]
synonym: "chalcone synthetase activity" EXACT []
synonym: "CHS" EXACT []
synonym: "DOCS" NARROW []
synonym: "flavanone synthase activity" EXACT [EC:2.3.1.74]
synonym: "flavonone synthase activity" EXACT [EC:2.3.1.74]
synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.74]
xref: EC:2.3.1.74
xref: MetaCyc:NARINGENIN-CHALCONE-SYNTHASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0016211
name: ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl]
subset: gosubset_prok
xref: EC:6.3.1.-
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0016212
name: kynurenine-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate." [EC:2.6.1.7]
subset: gosubset_prok
synonym: "kynurenine 2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.7]
synonym: "kynurenine aminotransferase activity" EXACT [EC:2.6.1.7]
synonym: "kynurenine transaminase (cyclizing)" EXACT [EC:2.6.1.7]
synonym: "kynurenine--oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.7]
synonym: "kynurenine-oxoglutarate aminotransferase activity" EXACT []
synonym: "L-kynurenine aminotransferase activity" EXACT [EC:2.6.1.7]
synonym: "L-kynurenine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.7]
xref: EC:2.6.1.7
xref: MetaCyc:2.6.1.7-RXN
xref: Reactome:24302 "kynurenine-oxoglutarate transaminase activity"
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0016213
name: linoleoyl-CoA desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O." [EC:1.14.19.3]
comment: Note that this function was formerly EC:1.14.99.25.
subset: gosubset_prok
synonym: "delta(6)-acyl CoA desaturase activity" BROAD []
synonym: "delta(6)-desaturase activity" BROAD []
synonym: "delta(6)-fatty acyl-CoA desaturase activity" BROAD []
synonym: "delta6-acyl CoA desaturase activity" EXACT [EC:1.14.19.3]
synonym: "delta6-desaturase activity" EXACT [EC:1.14.19.3]
synonym: "delta6-fatty acyl-CoA desaturase activity" EXACT [EC:1.14.19.3]
synonym: "fatty acid 6-desaturase activity" BROAD []
synonym: "fatty acid delta(6)-desaturase activity" BROAD []
synonym: "fatty acid delta6-desaturase activity" EXACT [EC:1.14.19.3]
synonym: "linoleate desaturase activity" RELATED []
synonym: "linoleic acid desaturase activity" RELATED []
synonym: "linoleic desaturase activity" RELATED []
synonym: "linoleoyl CoA desaturase activity" EXACT []
synonym: "linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.3]
synonym: "linoleoyl-coenzyme A desaturase activity" EXACT []
synonym: "long-chain fatty acid delta(6)-desaturase activity" BROAD []
synonym: "long-chain fatty acid delta6-desaturase activity" EXACT [EC:1.14.19.3]
xref: EC:1.14.19.3
xref: MetaCyc:1.14.19.3-RXN
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0016215
name: CoA desaturase activity
namespace: molecular_function
subset: gosubset_prok
xref: EC:1.14.99.-
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016216
name: isopenicillin-N synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine = isopenicillin-N + H2O." [EC:1.21.3.1, PMID:12926272]
subset: gosubset_prok
synonym: "isopenicillin N synthase activity" EXACT [EC:1.21.3.1]
synonym: "isopenicillin-N synthetase activity" EXACT []
synonym: "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.21.3.1]
xref: EC:1.21.3.1
xref: MetaCyc:1.21.3.1-RXN
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0016217
name: N-ethylammeline chlorohydrolase activity
namespace: molecular_function
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016218
name: polyketide synthase activity
namespace: molecular_function
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016219
name: GDP-dissociation stimulator activity
namespace: molecular_function
synonym: "GDS" EXACT []
is_a: GO:0005083 ! small GTPase regulator activity

[Term]
id: GO:0016220
name: RAL GDP-dissociation stimulator activity
namespace: molecular_function
is_a: GO:0016219 ! GDP-dissociation stimulator activity

[Term]
id: GO:0016222
name: procollagen-proline 4-dioxygenase complex
namespace: cellular_component
def: "A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase." [PMID:14500733, PMID:7753822]
synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex" EXACT [EC:1.14.11.2]
synonym: "prolyl 4-hydroxylase complex" BROAD [EC:1.14.11.2]
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0016223
name: beta-alanine-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine." [EC:2.6.1.18]
subset: gosubset_prok
synonym: "beta-alanine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.18]
synonym: "beta-alanine-alpha-alanine transaminase activity" EXACT [EC:2.6.1.18]
synonym: "beta-alanine-pyruvate aminotransferase activity" EXACT []
synonym: "L-alanine:3-oxopropanoate aminotransferase activity" EXACT [EC:2.6.1.18]
synonym: "omega-amino acid--pyruvate aminotransferase activity" EXACT [EC:2.6.1.18]
xref: EC:2.6.1.18
xref: MetaCyc:2.6.1.18-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0016226
name: iron-sulfur cluster assembly
namespace: biological_process
def: "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:mah]
subset: gosubset_prok
synonym: "iron-sulfur cluster biosynthesis" EXACT []
synonym: "iron-sulphur cluster assembly" EXACT []
is_a: GO:0031163 ! metallo-sulfur cluster assembly

[Term]
id: GO:0016227
name: tRNA sulfurtransferase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4]
comment: This term was made obsolete because tRNA thionucleotide formation is a multistep process; there is no single reaction in which cysteine reacts with an activated tRNA directly
synonym: "L-cysteine:tRNA sulfurtransferase activity" EXACT [EC:2.8.1.4]
synonym: "ribonucleate sulfurtransferase activity" EXACT [EC:2.8.1.4]
synonym: "RNA sulfurtransferase activity" EXACT [EC:2.8.1.4]
synonym: "transfer ribonucleate sulfurtransferase activity" EXACT [EC:2.8.1.4]
synonym: "transfer RNA sulfurtransferase activity" EXACT [EC:2.8.1.4]
synonym: "transfer RNA thiolase activity" EXACT [EC:2.8.1.4]
synonym: "tRNA sulphurtransferase activity" EXACT []
xref: EC:2.8.1.4
xref: MetaCyc:TRNA-S-TRANSFERASE-RXN
is_obsolete: true
replaced_by: GO:0034227
consider: GO:0016783

[Term]
id: GO:0016229
name: steroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative." [GOC:mah]
subset: gosubset_prok
xref: EC:1.1.1.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016230
name: sphingomyelin phosphodiesterase activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme sphingomyelin phosphodiesterase." [GOC:ai]
synonym: "neutral sphingomyelinase activator" EXACT []
is_a: GO:0016004 ! phospholipase activator activity

[Term]
id: GO:0016231
name: beta-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN]
is_a: GO:0004563 ! beta-N-acetylhexosaminidase activity

[Term]
id: GO:0016232
name: HNK-1 sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1,3)-Gal-beta-(1,4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1,3)-Gal-beta-(1,4)-GlcNAc-beta-(1->R)." [PMID:9478973]
synonym: "HNK-1 sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0016233
name: telomere capping
namespace: biological_process
def: "A process by which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055]
synonym: "telomere end protection" EXACT []
xref: Reactome:176700 "Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure"
xref: Reactome:181450 "Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure"
is_a: GO:0000723 ! telomere maintenance

[Term]
id: GO:0016234
name: inclusion body
namespace: cellular_component
def: "A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744]
xref: Wikipedia:Inclusion_bodies
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0016235
name: aggresome
namespace: cellular_component
def: "An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules." [PMID:11121744]
xref: Wikipedia:Aggresome
is_a: GO:0016234 ! inclusion body

[Term]
id: GO:0016236
name: macroautophagy
namespace: biological_process
alt_id: GO:0034262
def: "The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane-bounded autophagic bodies which are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:9412464]
synonym: "autophagy in response to cellular starvation" EXACT []
synonym: "non-specific autophagy" EXACT []
synonym: "starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006914 ! autophagy
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0016237
name: microautophagy
namespace: biological_process
def: "The transfer of cytosolic components into the lysosomal compartment by direct invagination of the lysosomal membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. In S. cerevisiae, the vacuole is the lysosomal compartment." [PMID:14679207, PMID:15798367, PMID:16973210, PMID:9566964]
is_a: GO:0006914 ! autophagy
is_a: GO:0010324 ! membrane invagination

[Term]
id: GO:0016238
name: chaperone-mediated autophagy
namespace: biological_process
is_a: GO:0006914 ! autophagy

[Term]
id: GO:0016239
name: positive regulation of macroautophagy
namespace: biological_process
def: "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464]
synonym: "activation of macroautophagy" NARROW []
synonym: "positive regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "stimulation of macroautophagy" NARROW []
synonym: "up regulation of macroautophagy" EXACT []
synonym: "up-regulation of macroautophagy" EXACT []
synonym: "upregulation of macroautophagy" EXACT []
is_a: GO:0010508 ! positive regulation of autophagy
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0016241 ! regulation of macroautophagy
is_a: GO:0032109 ! positive regulation of response to nutrient levels
relationship: positively_regulates GO:0016236 ! macroautophagy

[Term]
id: GO:0016240
name: autophagic vacuole docking
namespace: biological_process
is_a: GO:0022406 ! membrane docking
relationship: part_of GO:0016236 ! macroautophagy

[Term]
id: GO:0016241
name: regulation of macroautophagy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc]
synonym: "regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010506 ! regulation of autophagy
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0016236 ! macroautophagy

[Term]
id: GO:0016242
name: negative regulation of macroautophagy
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators]
synonym: "down regulation of macroautophagy" EXACT []
synonym: "down-regulation of macroautophagy" EXACT []
synonym: "downregulation of macroautophagy" EXACT []
synonym: "inhibition of macroautophagy" NARROW []
synonym: "negative regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010507 ! negative regulation of autophagy
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0016241 ! regulation of macroautophagy
is_a: GO:0032108 ! negative regulation of response to nutrient levels
relationship: negatively_regulates GO:0016236 ! macroautophagy

[Term]
id: GO:0016243
name: regulation of autophagic vacuole size
namespace: biological_process
def: "Any process that modulates the size of the autophagic vacuole." [GOC:krc]
is_a: GO:0032535 ! regulation of cellular component size
relationship: part_of GO:0016236 ! macroautophagy

[Term]
id: GO:0016246
name: RNA interference
namespace: biological_process
def: "The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
comment: Note that this term refers specifically to posttranscriptional mechanisms by which small interfering RNAs down-regulate gene expression. Also consider annotating to other descendants of 'gene silencing by RNA ; GO:0031047'.
synonym: "posttranscriptional gene silencing by siRNA" EXACT [GOC:mah]
synonym: "RNAi" EXACT []
xref: Wikipedia:RNA_interference
is_a: GO:0035194 ! posttranscriptional gene silencing by RNA

[Term]
id: GO:0016247
name: channel regulator activity
namespace: molecular_function
def: "Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah]
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016248
name: channel inhibitor activity
namespace: molecular_function
def: "Stops, prevents, or reduces the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016247 ! channel regulator activity

[Term]
id: GO:0016250
name: N-sulfoglucosamine sulfohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + SO4(2-) (sulfate)." [EC:3.10.1.1]
synonym: "2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase)" EXACT [EC:3.10.1.1]
synonym: "heparin sulfamidase activity" EXACT [EC:3.10.1.1]
synonym: "N-sulfo-D-glucosamine sulfohydrolase activity" EXACT [EC:3.10.1.1]
synonym: "N-sulphoglucosamine sulphohydrolase activity" EXACT []
synonym: "sulfoglucosamine sulfamidase activity" EXACT [EC:3.10.1.1]
synonym: "sulphamidase activity" EXACT [EC:3.10.1.1]
xref: EC:3.10.1.1
xref: MetaCyc:N-SULFOGLUCOSAMINE-SULFOHYDROLASE-RXN
is_a: GO:0016826 ! hydrolase activity, acting on acid sulfur-nitrogen bonds

[Term]
id: GO:0016251
name: general RNA polymerase II transcription factor activity
namespace: molecular_function
alt_id: GO:0003703
def: "Any function that supports basal (unregulated) transcription of genes by core RNA polymerase II. Five general transcription factors are necessary and sufficient for such basal transcription in yeast: TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBF)." [PMID:10384286, PMID:9774831]
is_a: GO:0003702 ! RNA polymerase II transcription factor activity

[Term]
id: GO:0016252
name: nonspecific RNA polymerase II transcription factor activity
namespace: molecular_function
def: "Any function that supports transcription of genes by RNA polymerase II, and is not specific to a particular gene or gene set." [GOC:jl]
is_a: GO:0003702 ! RNA polymerase II transcription factor activity

[Term]
id: GO:0016254
name: preassembly of GPI anchor in ER membrane
namespace: biological_process
def: "The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane." [ISBN:0879695595]
subset: gosubset_prok
synonym: "preassembly of GPI anchor in endoplasmic reticulum membrane" EXACT []
xref: Reactome:162710 "Synthesis of glycosylphosphatidylinositol (GPI)"
xref: Reactome:448466 "Synthesis of glycosylphosphatidylinositol (GPI)"
xref: Reactome:469596 "Synthesis of glycosylphosphatidylinositol (GPI)"
xref: Reactome:487315 "Synthesis of glycosylphosphatidylinositol (GPI)"
xref: Reactome:507266 "Synthesis of glycosylphosphatidylinositol (GPI)"
xref: Reactome:517283 "Synthesis of glycosylphosphatidylinositol (GPI)"
xref: Reactome:526161 "Synthesis of glycosylphosphatidylinositol (GPI)"
xref: Reactome:531058 "Synthesis of glycosylphosphatidylinositol (GPI)"
xref: Reactome:536440 "Synthesis of glycosylphosphatidylinositol (GPI)"
xref: Reactome:542135 "Synthesis of glycosylphosphatidylinositol (GPI)"
xref: Reactome:547502 "Synthesis of glycosylphosphatidylinositol (GPI)"
xref: Reactome:557673 "Synthesis of glycosylphosphatidylinositol (GPI)"
xref: Reactome:568293 "Synthesis of glycosylphosphatidylinositol (GPI)"
xref: Reactome:581495 "Synthesis of glycosylphosphatidylinositol (GPI)"
xref: Reactome:585739 "Synthesis of glycosylphosphatidylinositol (GPI)"
xref: Reactome:592392 "Synthesis of glycosylphosphatidylinositol (GPI)"
xref: Reactome:595282 "Synthesis of glycosylphosphatidylinositol (GPI)"
is_a: GO:0006650 ! glycerophospholipid metabolic process
relationship: part_of GO:0006506 ! GPI anchor biosynthetic process

[Term]
id: GO:0016255
name: attachment of GPI anchor to protein
namespace: biological_process
def: "A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain." [ISBN:0879695595]
subset: gosubset_prok
xref: Reactome:162791 "Attachment of GPI anchor to uPAR"
xref: Reactome:449308 "Attachment of GPI anchor to uPAR"
xref: Reactome:470427 "Attachment of GPI anchor to uPAR"
xref: Reactome:508074 "Attachment of GPI anchor to uPAR"
is_a: GO:0043687 ! post-translational protein modification
relationship: part_of GO:0006506 ! GPI anchor biosynthetic process

[Term]
id: GO:0016256
name: N-glycan processing to lysosome
namespace: biological_process
def: "The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome." [ISBN:0879695595]
is_a: GO:0006491 ! N-glycan processing
relationship: part_of GO:0006622 ! protein targeting to lysosome

[Term]
id: GO:0016257
name: N-glycan processing to secreted and cell-surface N-glycans
namespace: biological_process
def: "The modification of high-mannose (Man9-Asn) N-glycans by mannosyl-oligosaccharide 1,2-alpha-mannosidase. This may result in Man8GlcNAc2-Asn N-glycans (which in yeast may be subsequently modified by the addition of further mannose residues) or Man5GlcNAc2-Asn N-glycans that are substrates for further diversification in the Golgi apparatus." [ISBN:0879695595]
subset: gosubset_prok
is_a: GO:0006491 ! N-glycan processing

[Term]
id: GO:0016258
name: N-glycan diversification
namespace: biological_process
def: "The generation, in the Golgi apparatus, of side chain diversity from high mannose Man5GlcNAc2-Asn N-glycans by specific glycosyltransferases and glycosidases." [ISBN:0879695595]
subset: gosubset_prok
is_a: GO:0006491 ! N-glycan processing

[Term]
id: GO:0016259
name: selenocysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "selenocysteine metabolism" EXACT []
is_a: GO:0000096 ! sulfur amino acid metabolic process
is_a: GO:0001887 ! selenium metabolic process
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0016260
name: selenocysteine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "selenocysteine anabolism" EXACT []
synonym: "selenocysteine biosynthesis" EXACT []
synonym: "selenocysteine formation" EXACT []
synonym: "selenocysteine synthesis" EXACT []
is_a: GO:0000097 ! sulfur amino acid biosynthetic process
is_a: GO:0009070 ! serine family amino acid biosynthetic process
is_a: GO:0016259 ! selenocysteine metabolic process

[Term]
id: GO:0016261
name: selenocysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "selenocysteine breakdown" EXACT []
synonym: "selenocysteine catabolism" EXACT []
synonym: "selenocysteine degradation" EXACT []
is_a: GO:0000098 ! sulfur amino acid catabolic process
is_a: GO:0009071 ! serine family amino acid catabolic process
is_a: GO:0016259 ! selenocysteine metabolic process

[Term]
id: GO:0016262
name: protein N-acetylglucosaminyltransferase activity
namespace: molecular_function
alt_id: GO:0016253
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein." [EC:2.4.1.94]
synonym: "N-GlcNAc transferase activity" EXACT [EC:2.4.1.94]
synonym: "O-GlcNAc transferase activity" EXACT []
synonym: "UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase activity" EXACT []
synonym: "UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase activity" EXACT []
synonym: "uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase activity" EXACT []
xref: EC:2.4.1.94
xref: MetaCyc:2.4.1.94-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0016263
name: glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan." [EC:2.4.1.122, GOC:ma]
synonym: "Core 1 GalT" RELATED []
synonym: "UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.122]
synonym: "UDPgalactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.122]
synonym: "uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase activity" EXACT [EC:2.4.1.122]
xref: EC:2.4.1.122
xref: MetaCyc:2.4.1.122-RXN
is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity

[Term]
id: GO:0016264
name: gap junction assembly
namespace: biological_process
def: "Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids." [GOC:jic, ISBN:0716731363]
xref: Reactome:190861 "Gap junction assembly"
xref: Reactome:448819 "Gap junction assembly"
xref: Reactome:469935 "Gap junction assembly"
xref: Reactome:487638 "Gap junction assembly"
xref: Reactome:507597 "Gap junction assembly"
is_a: GO:0007043 ! cell-cell junction assembly

[Term]
id: GO:0016265
name: death
namespace: biological_process
def: "A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism." [GOC:mah, ISBN:0877797099]
comment: See also the biological process term 'apoptosis ; GO:0006915'.
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
xref: Wikipedia:Death
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0016266
name: O-glycan processing
namespace: biological_process
def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form a core O-glycan structure." [GOC:mah, PMID:10580130]
subset: gosubset_prok
is_a: GO:0006493 ! protein amino acid O-linked glycosylation

[Term]
id: GO:0016267
name: O-glycan processing, core 1
namespace: biological_process
def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-1->3-GalNAc." [GOC:mah, PMID:10580130]
subset: gosubset_prok
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0016268
name: O-glycan processing, core 2
namespace: biological_process
def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 2 O-glycan structure, GlcNAc-beta-1->6(Gal-beta-1->3)-GalNAc." [GOC:mah, PMID:10580130]
subset: gosubset_prok
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0016269
name: O-glycan processing, core 3
namespace: biological_process
def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 3 O-glycan structure, GlcNAc-beta-1->3-GalNAc." [GOC:mah, PMID:10580130]
subset: gosubset_prok
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0016270
name: O-glycan processing, core 4
namespace: biological_process
def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 4 O-glycan structure, GlcNAc-beta-1->6(GlcNAc-beta-1->3)-GalNAc." [GOC:mah, PMID:10580130]
subset: gosubset_prok
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0016271
name: tissue death
namespace: biological_process
def: "A permanent cessation of all vital functions of a tissue." [GOC:dph]
is_a: GO:0016265 ! death

[Term]
id: GO:0016272
name: prefoldin complex
namespace: cellular_component
def: "A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits." [GOC:jl, PMID:17384227, PMID:9630229]
subset: gosubset_prok
synonym: "GIM complex" NARROW []
xref: Wikipedia:Prefoldin
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0016273
name: arginine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue." [GOC:mah]
xref: EC:2.1.1.-
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016274
name: protein-arginine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue in a protein substrate." [GOC:mah, PMID:12351636]
synonym: "PRMT activity" EXACT []
xref: EC:2.1.1.-
xref: MetaCyc:2.1.1.125-RXN
xref: MetaCyc:2.1.1.126-RXN
xref: Reactome:24476 "protein-arginine N-methyltransferase activity"
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0016273 ! arginine N-methyltransferase activity

[Term]
id: GO:0016275
name: [cytochrome c]-arginine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (cytochrome c)-arginine = S-adenosyl-L-homocysteine + (cytochrome c)-N(omega)-methyl-arginine." [EC:2.1.1.124, GOC:ma]
synonym: "cytochrome c-arginine N-methyltransferase activity" EXACT [EC:2.1.1.124]
synonym: "S-adenosyl-L-methionine:cytochrome c-arginine nomega-methyltransferasea" RELATED [EC:2.1.1.124]
synonym: "S-adenosyl-L-methionine:cytochrome c-arginine omega-N-methyltransferasea" RELATED [EC:2.1.1.124]
xref: EC:2.1.1.124
xref: MetaCyc:2.1.1.124-RXN
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity

[Term]
id: GO:0016277
name: [myelin basic protein]-arginine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine." [EC:2.1.1.126]
synonym: "myelin basic protein methylase activity" EXACT [EC:2.1.1.126]
synonym: "myelin basic protein methylase I" RELATED [EC:2.1.1.126]
synonym: "myelin basic protein-arginine N-methyltransferase activity" EXACT [EC:2.1.1.126]
synonym: "protein methylase I activity" BROAD [EC:2.1.1.126]
synonym: "S-adenosyl-L-methionine:myelin-basic-protein-arginine nomega-methyltransferase activity" EXACT [EC:2.1.1.126]
synonym: "S-adenosyl-L-methionine:myelin-basic-protein-arginine omega-N-methyltransferase activity" EXACT [EC:2.1.1.126]
xref: EC:2.1.1.126
xref: MetaCyc:2.1.1.126-RXN
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity

[Term]
id: GO:0016278
name: lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue." [GOC:mah]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016279
name: protein-lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0016278 ! lysine N-methyltransferase activity

[Term]
id: GO:0016281
name: eukaryotic translation initiation factor 4F complex
namespace: cellular_component
def: "The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:8449919]
synonym: "eIF-4F" EXACT []
synonym: "eukaryotic translation initiation factor 4 complex" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0016282
name: eukaryotic 43S preinitiation complex
namespace: cellular_component
def: "A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049]
synonym: "eukaryotic 43S pre-initiation complex" EXACT []
is_a: GO:0070993 ! translation preinitiation complex

[Term]
id: GO:0016284
name: alanine aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide." [GOC:jl]
comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined.
subset: gosubset_prok
xref: EC:3.4.11.-
is_obsolete: true
replaced_by: GO:0004177
replaced_by: GO:0008235

[Term]
id: GO:0016285
name: cytosol alanyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides." [EC:3.4.11.14]
comment: This term was made obsolete because it represents a gene product and refers to cellular component information.
subset: gosubset_prok
synonym: "aminopolypeptidase activity" EXACT [EC:3.4.11.14]
synonym: "arylamidase activity" NARROW [EC:3.4.11.14]
synonym: "cytosol aminopeptidase III activity" NARROW [EC:3.4.11.14]
synonym: "human liver aminopeptidase" NARROW [EC:3.4.11.14]
synonym: "liver aminopeptidase activity" NARROW [EC:3.4.11.14]
synonym: "puromycin-sensitive aminopeptidase activity" NARROW [EC:3.4.11.14]
synonym: "soluble alanyl aminopeptidase activity" EXACT [EC:3.4.11.14]
synonym: "thiol-activated aminopeptidase activity" EXACT [EC:3.4.11.14]
xref: EC:3.4.11.14
xref: MetaCyc:3.4.11.14-RXN
is_obsolete: true
replaced_by: GO:0004177
replaced_by: GO:0008235

[Term]
id: GO:0016286
name: small conductance calcium-activated potassium channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754]
synonym: "SK calcium-activated potassium channel activity " EXACT []
synonym: "SK KCa channels" EXACT []
synonym: "small conductance KCa channels " EXACT []
is_a: GO:0015269 ! calcium-activated potassium channel activity

[Term]
id: GO:0016287
name: glycerone-phosphate O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate." [EC:2.3.1.42]
synonym: "acyl-CoA:glycerone-phosphate O-acyltransferase activity" EXACT [EC:2.3.1.42]
synonym: "dihydroxyacetone phosphate acyltransferase activity" EXACT [EC:2.3.1.42]
xref: EC:2.3.1.42
xref: MetaCyc:2.3.1.42-RXN
xref: Reactome:24512 "glycerone-phosphate O-acyltransferase activity"
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0016289
name: CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group." [GOC:ai]
subset: gosubset_prok
xref: EC:3.1.2.-
xref: Reactome:10046 "CoA hydrolase activity"
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0016290
name: palmitoyl-CoA hydrolase activity
namespace: molecular_function
alt_id: GO:0016293
def: "Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate." [EC:3.1.2.2]
subset: gosubset_prok
synonym: "fatty acyl thioesterase I" RELATED [EC:3.1.2.2]
synonym: "long-chain fatty-acyl-CoA hydrolase activity" EXACT []
synonym: "palmitoyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.2]
synonym: "palmitoyl thioesterase activity" EXACT [EC:3.1.2.2]
synonym: "palmitoyl-CoA deacylase activity" EXACT [EC:3.1.2.2]
synonym: "palmityl thioesterase activity" EXACT [EC:3.1.2.2]
synonym: "palmityl thioesterase I" RELATED [EC:3.1.2.2]
synonym: "palmityl-CoA deacylase activity" EXACT [EC:3.1.2.2]
xref: EC:3.1.2.2
xref: MetaCyc:PALMITOYL-COA-HYDROLASE-RXN
xref: MetaCyc:PWY-5148
is_a: GO:0016291 ! acyl-CoA thioesterase activity

[Term]
id: GO:0016291
name: acyl-CoA thioesterase activity
namespace: molecular_function
alt_id: GO:0008778
alt_id: GO:0016292
def: "Catalysis of the reaction: acyl-CoA + H2O = corresponding fatty acid + CoA." [PMID:14660652]
subset: gosubset_prok
synonym: "acyl-CoA thioesterase I activity" NARROW []
synonym: "acyl-CoA thioesterase II activity" NARROW []
synonym: "acyl-CoA thiolesterase activity" EXACT []
xref: EC:3.1.2.-
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0016295
name: myristoyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate." [EC:3.1.2.14]
synonym: "myristoyl-[acyl-carrier protein] hydrolase activity" EXACT []
synonym: "myristoyl-ACP hydrolase activity" EXACT []
synonym: "tetradecanoyl-[acyl-carrier-protein] hydrolase activity" EXACT []
synonym: "tetradecanoyl-ACP hydrolase activity" EXACT []
is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity

[Term]
id: GO:0016296
name: palmitoyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate." [EC:3.1.2.14]
synonym: "palmitoyl-[acyl-carrier protein] hydrolase activity" EXACT []
synonym: "palmitoyl-ACP hydrolase activity" EXACT []
is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity

[Term]
id: GO:0016297
name: acyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
alt_id: GO:0010281
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + organic acid." [EC:3.1.2.14]
subset: gosubset_prok
synonym: "acyl-[acyl-carrier protein] hydrolase activity" EXACT []
synonym: "acyl-ACP hydrolase activity" EXACT []
synonym: "acyl-ACP thioesterase activity" EXACT []
synonym: "acyl-ACP-hydrolase activity" EXACT [EC:3.1.2.14]
synonym: "acyl-acyl carrier protein hydrolase activity" EXACT [EC:3.1.2.14]
synonym: "acyl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.14]
synonym: "S-acyl fatty acid synthase thioesterase activity" EXACT [EC:3.1.2.14]
xref: MetaCyc:3.1.2.14-RXN
is_a: GO:0004312 ! fatty-acid synthase activity
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0016298
name: lipase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah]
subset: gosubset_prok
xref: EC:3.1.1.-
xref: Reactome:1913 "lipase activity"
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0016299
name: regulator of G-protein signaling activity
namespace: molecular_function
def: "OBSOLETE. Inhibits signal transduction the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form." [GOC:curators]
comment: This term was made obsolete because it refers to a combination of a function and a process.
synonym: "regulator of G protein signaling activity" EXACT []
synonym: "regulator of G protein signalling activity" EXACT []
synonym: "regulator of G-protein signalling activity" EXACT []
synonym: "RGS" EXACT []
is_obsolete: true
consider: GO:0005095
consider: GO:0034260
consider: GO:0045744

[Term]
id: GO:0016300
name: tRNA (uracil) methyltransferase activity
namespace: molecular_function
alt_id: GO:0016431
def: "Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule." [GOC:mah]
comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698).
subset: gosubset_prok
synonym: "tRNA (uridine) methyltransferase activity" EXACT []
xref: EC:2.1.1.-
is_a: GO:0008175 ! tRNA methyltransferase activity

[Term]
id: GO:0016301
name: kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term.
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: gosubset_prok
synonym: "phosphokinase activity" EXACT []
xref: Reactome:1423 "kinase activity"
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016303
name: 1-phosphatidylinositol-3-kinase activity
namespace: molecular_function
alt_id: GO:0004429
def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137, PMID:9759495]
synonym: "1-phosphatidylinositol 3-kinase activity" EXACT []
synonym: "ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity" EXACT [EC:2.7.1.137]
synonym: "phosphatidylinositol 3-kinase activity" EXACT []
synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW []
synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW []
synonym: "phosphatidylinositol 3-kinase activity, class III" NARROW []
synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW []
synonym: "PI3-kinase activity" EXACT [EC:2.7.1.137]
synonym: "PI3K" EXACT []
synonym: "PtdIns-3-kinase activity" EXACT [EC:2.7.1.137]
synonym: "type I phosphatidylinositol kinase activity" NARROW [EC:2.7.1.137]
synonym: "type III phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.137]
synonym: "Vps34p" RELATED [EC:2.7.1.137]
xref: EC:2.7.1.137
xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN
xref: Reactome:19935 "1-phosphatidylinositol-3-kinase activity"
is_a: GO:0035004 ! phosphoinositide 3-kinase activity

[Term]
id: GO:0016304
name: phosphatidylinositol 3-kinase activity, class I
namespace: molecular_function
def: "OBSOLETE. A heterodimeric phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol, phosphatidylinositol-4-phosphate or phosphatidylinositol-4,5-bisphosphate. Also possesses intrinsic protein kinase activity." [PMID:9759495]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
replaced_by: GO:0016303
replaced_by: GO:0035005
replaced_by: GO:0046934

[Term]
id: GO:0016305
name: phosphatidylinositol 3-kinase activity, class II
namespace: molecular_function
def: "OBSOLETE. A phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol and phosphatidylinositol-4-phosphate; the human form can phosphorylate phosphatidylinositol-4,5-bisphosphate in the presence of phosphatidylserine." [PMID:9759495]
comment: This term was made obsolete because it represents a class of gene products.
synonym: "PI3KC2" EXACT []
is_obsolete: true
consider: GO:0016303
consider: GO:0035005
consider: GO:0046934

[Term]
id: GO:0016306
name: phosphatidylinositol 3-kinase activity, class III
namespace: molecular_function
def: "OBSOLETE. A phosphoinositide 3-kinase which can only phosphorylate phosphatidylinositol." [PMID:9759495]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
replaced_by: GO:0016303

[Term]
id: GO:0016307
name: phosphatidylinositol phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495]
subset: gosubset_prok
xref: EC:2.7.1.-
is_a: GO:0001727 ! lipid kinase activity
is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0016308
name: 1-phosphatidylinositol-4-phosphate 5-kinase activity
namespace: molecular_function
alt_id: GO:0004431
alt_id: GO:0045215
def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [EC:2.7.1.68]
subset: gosubset_prok
synonym: "1-phosphatidylinositol-4-phosphate kinase activity" BROAD []
synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA" NARROW []
synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB" NARROW []
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.68]
synonym: "diphosphoinositide kinase activity" BROAD [EC:2.7.1.68]
synonym: "phosphatidylinositol 4-phosphate kinase activity" BROAD [EC:2.7.1.68]
synonym: "phosphatidylinositol-4-phosphate 5-kinase activity" EXACT [EC:2.7.1.68]
synonym: "PIP kinase activity" BROAD [EC:2.7.1.68]
synonym: "PIP5K" EXACT []
synonym: "PtdIns(4)P-5-kinase activity" EXACT [EC:2.7.1.68]
synonym: "type I PIP kinase activity" NARROW [EC:2.7.1.68]
xref: EC:2.7.1.68
xref: MetaCyc:2.7.1.68-RXN
is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity

[Term]
id: GO:0016309
name: 1-phosphatidylinositol-5-phosphate 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [EC:2.7.1.149]
synonym: "1-phosphatidylinositol-5-phosphate kinase" BROAD []
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase activity" EXACT [EC:2.7.1.149]
synonym: "PIP4K" EXACT []
synonym: "type II PIP kinase activity" NARROW [EC:2.7.1.149]
xref: EC:2.7.1.149
xref: MetaCyc:2.7.1.149-RXN
is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity

[Term]
id: GO:0016310
name: phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: Wikipedia:Phosphorylation
is_a: GO:0006796 ! phosphate metabolic process

[Term]
id: GO:0016311
name: dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: Wikipedia:Dephosphorylation
is_a: GO:0006796 ! phosphate metabolic process

[Term]
id: GO:0016312
name: inositol bisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the removal of one of the two phosphate groups of an inositol bisphosphate." [GOC:hb]
xref: EC:3.1.3.-
is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity

[Term]
id: GO:0016313
name: inositol-1,4,5-trisphosphate phosphatase
namespace: molecular_function
def: "OBSOLETE. The removal of one of the phosphate groups from an inositol triphosphate to produce an inositol bisphosphate." [GOC:hb]
comment: This term was made obsolete because it is a redundant grouping term with only one child.
is_obsolete: true
consider: GO:0046030

[Term]
id: GO:0016314
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidyl inositol-4,5-bisphosphate + phosphate." [EC:3.1.3.67]
synonym: "1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.67]
synonym: "MMAC1" RELATED [EC:3.1.3.67]
synonym: "phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.67]
xref: EC:3.1.3.67
xref: MetaCyc:3.1.3.67-RXN
xref: Reactome:24758 "phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"
is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity
is_a: GO:0042577 ! lipid phosphatase activity

[Term]
id: GO:0016316
name: phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
namespace: molecular_function
alt_id: GO:0004440
def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [EC:3.1.3.66, GOC:hb]
synonym: "1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.66]
synonym: "D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.66]
synonym: "inositol polyphosphate 4-phosphatase type II activity" RELATED [EC:3.1.3.66]
synonym: "inositol-1,4,-bisphosphate 4-phosphatase activity" EXACT []
synonym: "inositol-3,4-bisphosphate 4-phosphatase activity" EXACT []
xref: EC:3.1.3.66
xref: MetaCyc:3.1.3.66-RXN
is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity
is_a: GO:0034596 ! phosphoinositide 4-phosphatase activity
is_a: GO:0042577 ! lipid phosphatase activity

[Term]
id: GO:0016318
name: ommatidial rotation
namespace: biological_process
def: "The process by which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity

[Term]
id: GO:0016319
name: mushroom body development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0016320
name: endoplasmic reticulum membrane fusion
namespace: biological_process
def: "The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum." [GOC:elh, GOC:jic]
synonym: "ER membrane fusion" EXACT []
is_a: GO:0048284 ! organelle fusion
is_a: GO:0090174 ! organelle membrane fusion

[Term]
id: GO:0016321
name: female meiosis chromosome segregation
namespace: biological_process
def: "The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0045132 ! meiotic chromosome segregation
relationship: part_of GO:0007143 ! female meiosis

[Term]
id: GO:0016322
name: neuron remodeling
namespace: biological_process
def: "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]
synonym: "neuronal remodeling" EXACT []
is_a: GO:0042551 ! neuron maturation

[Term]
id: GO:0016323
name: basolateral plasma membrane
namespace: cellular_component
def: "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0016324
name: apical plasma membrane
namespace: cellular_component
def: "The region of the plasma membrane located at the apical end of the cell." [GOC:curators]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0045177 ! apical part of cell

[Term]
id: GO:0016325
name: oocyte microtubule cytoskeleton organization
namespace: biological_process
alt_id: GO:0048130
def: "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123]
synonym: "oocyte microtubule cytoskeleton organisation" EXACT [GOC:curators]
is_a: GO:0030951 ! establishment or maintenance of microtubule cytoskeleton polarity
relationship: part_of GO:0007308 ! oocyte construction

[Term]
id: GO:0016326
name: kinesin motor activity
namespace: molecular_function
def: "OBSOLETE. The hydrolysis of ATP (and GTP) that drives the microtubular motor along microtubules." [GOC:hb]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0003777

[Term]
id: GO:0016327
name: apicolateral plasma membrane
namespace: cellular_component
def: "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0016328
name: lateral plasma membrane
namespace: cellular_component
def: "The membranes on the sides of epithelial cells which lie at the interface of adjacent cells." [GOC:hb]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0016329
name: apoptosis regulator activity
namespace: molecular_function
def: "OBSOLETE. The function held by products which directly regulate any step in the process of apoptosis." [GOC:jl]
comment: This term was made obsolete because it represents involvement in a biological process.
is_obsolete: true
replaced_by: GO:0042981

[Term]
id: GO:0016330
name: second mitotic wave during compound eye morphogenesis
namespace: biological_process
def: "A discrete cell cycle that occurs during the third instar eye imaginal disc after progression of the morphogenetic furrow. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224]
is_a: GO:0007049 ! cell cycle
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0016331
name: morphogenesis of embryonic epithelium
namespace: biological_process
def: "The process by which the anatomical structures of embryonic epithelia are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0016332
name: establishment or maintenance of polarity of embryonic epithelium
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah]
is_a: GO:0007163 ! establishment or maintenance of cell polarity
relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium

[Term]
id: GO:0016333
name: morphogenesis of follicular epithelium
namespace: biological_process
def: "The process by which the anatomical structures of a follicular epithelium are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0016334
name: establishment or maintenance of polarity of follicular epithelium
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah]
is_a: GO:0007163 ! establishment or maintenance of cell polarity
relationship: part_of GO:0016333 ! morphogenesis of follicular epithelium

[Term]
id: GO:0016335
name: morphogenesis of larval imaginal disc epithelium
namespace: biological_process
def: "The process by which the anatomical structures of a larval imaginal disc epithelium are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jl]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0002168 ! instar larval development
relationship: part_of GO:0007560 ! imaginal disc morphogenesis

[Term]
id: GO:0016336
name: establishment or maintenance of polarity of larval imaginal disc epithelium
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium." [GOC:jl, GOC:mah]
is_a: GO:0007163 ! establishment or maintenance of cell polarity
relationship: part_of GO:0016335 ! morphogenesis of larval imaginal disc epithelium

[Term]
id: GO:0016337
name: cell-cell adhesion
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules." [GOC:hb]
subset: gosubset_prok
is_a: GO:0007155 ! cell adhesion

[Term]
id: GO:0016338
name: calcium-independent cell-cell adhesion
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb]
synonym: "calcium-independent cell adhesion molecule activity" RELATED []
is_a: GO:0016337 ! cell-cell adhesion

[Term]
id: GO:0016339
name: calcium-dependent cell-cell adhesion
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
synonym: "calcium-dependent cell adhesion molecule activity" RELATED []
is_a: GO:0016337 ! cell-cell adhesion

[Term]
id: GO:0016340
name: calcium-dependent cell-matrix adhesion
namespace: biological_process
def: "The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]
is_a: GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0016341
name: other collagen
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it is a redundant grouping term.
is_obsolete: true
replaced_by: GO:0005581

[Term]
id: GO:0016342
name: catenin complex
namespace: cellular_component
def: "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323]
is_a: GO:0019897 ! extrinsic to plasma membrane
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0016343
name: cytoskeletal anchoring activity
namespace: molecular_function
def: "OBSOLETE. The direct or indirect linkage of cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]
comment: This term was made obsolete because it represents a biological process.
is_obsolete: true
replaced_by: GO:0007016

[Term]
id: GO:0016344
name: meiotic chromosome movement towards spindle pole
namespace: biological_process
def: "The cell cycle process whereby the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis." [GOC:ai]
synonym: "chromosome migration to spindle pole during meiosis" EXACT []
synonym: "chromosome movement towards spindle pole during meiosis" EXACT []
synonym: "meiotic chromosome movement" BROAD []
synonym: "meiotic chromosome movement to spindle pole" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051305 ! chromosome movement towards spindle pole
relationship: part_of GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0016345
name: female meiotic chromosome movement towards spindle pole
namespace: biological_process
def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during female meiosis." [GOC:ai]
synonym: "chromosome movement towards spindle pole during female meiosis" EXACT []
synonym: "female meiotic chromosome movement" BROAD []
synonym: "female meiotic chromosome movement to spindle pole" EXACT []
is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole
relationship: part_of GO:0016321 ! female meiosis chromosome segregation

[Term]
id: GO:0016346
name: male meiotic chromosome movement towards spindle pole
namespace: biological_process
def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during male meiosis." [GOC:ai]
synonym: "chromosome movement towards spindle pole during male meiosis" EXACT []
synonym: "male meiotic chromosome movement" BROAD []
synonym: "male meiotic chromosome movement to spindle pole" EXACT []
is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole
relationship: part_of GO:0007060 ! male meiosis chromosome segregation

[Term]
id: GO:0016347
name: calcium-independent cell adhesion molecule activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0005515
consider: GO:0007161
consider: GO:0016021
consider: GO:0016338

[Term]
id: GO:0016348
name: imaginal disc-derived leg joint morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. Morphogenesis pertains to the creation of form. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cancerweb.ncl.ac.uk/]
is_a: GO:0035111 ! leg joint morphogenesis
relationship: part_of GO:0007480 ! imaginal disc-derived leg morphogenesis

[Term]
id: GO:0016351
name: drug susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0042493

[Term]
id: GO:0016352
name: insecticide susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0017085

[Term]
id: GO:0016353
name: carbamate susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046681

[Term]
id: GO:0016354
name: cyclodiene susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046682

[Term]
id: GO:0016355
name: DDT susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046680

[Term]
id: GO:0016356
name: organophosphorus susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046683

[Term]
id: GO:0016357
name: pyrethroid susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046684

[Term]
id: GO:0016358
name: dendrite development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0031175 ! neuron projection development
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0016360
name: sensory organ precursor cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
synonym: "sense organ precursor cell fate determination" EXACT [GOC:dph]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0008052 ! sensory organ boundary specification

[Term]
id: GO:0016361
name: activin receptor activity, type I
namespace: molecular_function
def: "Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals." [GOC:mah, PMID:8622651]
synonym: "type I activin receptor activity" EXACT []
is_a: GO:0005025 ! transforming growth factor beta receptor activity, type I
is_a: GO:0017002 ! activin receptor activity

[Term]
id: GO:0016362
name: activin receptor activity, type II
namespace: molecular_function
def: "Combining with activin to initiate a change in cell activity; upon ligand binding, binds to catalyzes the phosphorylation of type I activin receptor." [GOC:mah, PMID:8622651]
synonym: "type II activin receptor activity" EXACT []
xref: Reactome:24823 "activin receptor activity, type II"
is_a: GO:0005026 ! transforming growth factor beta receptor activity, type II
is_a: GO:0017002 ! activin receptor activity

[Term]
id: GO:0016363
name: nuclear matrix
namespace: cellular_component
def: "The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089]
synonym: "nucleoskeleton " EXACT []
xref: Wikipedia:Nuclear_matrix
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0034399 ! nuclear periphery

[Term]
id: GO:0016401
name: palmitoyl-CoA oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + H2O2." [GOC:jsg]
xref: EC:1.3.3.-
is_a: GO:0003997 ! acyl-CoA oxidase activity

[Term]
id: GO:0016402
name: pristanoyl-CoA oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + H2O2." [GOC:jsg]
xref: EC:1.3.3.-
xref: Reactome:25174 "pristanoyl-CoA oxidase activity"
is_a: GO:0003997 ! acyl-CoA oxidase activity

[Term]
id: GO:0016403
name: dimethylargininase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline." [EC:3.5.3.18]
subset: gosubset_prok
synonym: "dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18]
synonym: "N(G),N(G)-dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18]
synonym: "NG,NG-dimethyl-L-arginine dimethylamidohydrolase activity" EXACT [EC:3.5.3.18]
synonym: "NG,NG-dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18]
xref: EC:3.5.3.18
xref: MetaCyc:DIMETHYLARGININASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0016404
name: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141]
synonym: "(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" EXACT [EC:1.1.1.141]
synonym: "11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" EXACT [EC:1.1.1.141]
synonym: "15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141]
synonym: "15-hydroxyprostanoic dehydrogenase activity" EXACT [EC:1.1.1.141]
synonym: "15-OH-PGDH" RELATED [EC:1.1.1.141]
synonym: "NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)" EXACT [EC:1.1.1.141]
synonym: "NAD-specific 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141]
synonym: "prostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141]
xref: EC:1.1.1.141
xref: MetaCyc:1.1.1.141-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016405
name: CoA-ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai]
subset: gosubset_prok
xref: Reactome:10971 "CoA-ligase activity"
is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds

[Term]
id: GO:0016406
name: carnitine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0016407
name: acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai]
subset: gosubset_prok
synonym: "acetylase activity" EXACT []
xref: EC:2.3.1.-
xref: Reactome:1621 "acetyltransferase activity"
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0016408
name: C-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0016409
name: palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
xref: Reactome:2202 "palmitoyltransferase activity"
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0016410
name: N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
xref: Reactome:1095 "N-acyltransferase activity"
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0016411
name: acylglycerol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0016412
name: serine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0016413
name: O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0016414
name: O-octanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016415 ! octanoyltransferase activity

[Term]
id: GO:0016415
name: octanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0016416
name: O-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016409 ! palmitoyltransferase activity

[Term]
id: GO:0016417
name: S-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0016418
name: S-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0016407 ! acetyltransferase activity
is_a: GO:0016417 ! S-acyltransferase activity

[Term]
id: GO:0016419
name: S-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a malonyl group to a sulfur atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0016417 ! S-acyltransferase activity
is_a: GO:0016420 ! malonyltransferase activity

[Term]
id: GO:0016420
name: malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a malonyl (HOOC-CH2-CO-) group to an acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0016421
name: CoA carboxylase activity
namespace: molecular_function
subset: gosubset_prok
xref: EC:6.4.1.-
is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds

[Term]
id: GO:0016422
name: mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am." [EC:2.1.1.62]
synonym: "messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase activity" EXACT [EC:2.1.1.62]
synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.62]
synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.62]
xref: EC:2.1.1.62
xref: MetaCyc:2.1.1.62-RXN
is_a: GO:0008174 ! mRNA methyltransferase activity

[Term]
id: GO:0016423
name: tRNA (guanine) methyltransferase activity
namespace: molecular_function
alt_id: GO:0016424
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a guanine residue in a tRNA molecule." [GOC:mah]
subset: gosubset_prok
synonym: "tRNA (guanosine) methyltransferase activity" EXACT []
xref: EC:2.1.1.-
is_a: GO:0008175 ! tRNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016426
name: tRNA (adenine)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an adenine residue in a tRNA molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008175 ! tRNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016427
name: tRNA (cytosine)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a cytosine residue in a tRNA molecule." [GOC:mah]
xref: EC:2.1.1.-
is_a: GO:0008175 ! tRNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0016428
name: tRNA (cytosine-5-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine." [EC:2.1.1.29]
synonym: "S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.29]
synonym: "transfer ribonucleate cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.29]
synonym: "transfer RNA cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.29]
xref: EC:2.1.1.29
xref: MetaCyc:TRNA-CYTOSINE-5--METHYLTRANSFERASE-RXN
is_a: GO:0016427 ! tRNA (cytosine)-methyltransferase activity

[Term]
id: GO:0016429
name: tRNA (adenine-N1-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine." [EC:2.1.1.36]
subset: gosubset_prok
synonym: "1-methyladenine transfer RNA methyltransferase activity" EXACT [EC:2.1.1.36]
synonym: "adenine-1-methylase activity" EXACT [EC:2.1.1.36]
synonym: "S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.36]
synonym: "S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.36]
synonym: "transfer ribonucleate adenine 1-methyltransferase activity" EXACT [EC:2.1.1.36]
synonym: "transfer RNA (adenine-1) methyltransferase activity" EXACT [EC:2.1.1.36]
xref: EC:2.1.1.36
xref: MetaCyc:TRNA-ADENINE-N1--METHYLTRANSFERASE-RXN
is_a: GO:0016426 ! tRNA (adenine)-methyltransferase activity

[Term]
id: GO:0016430
name: tRNA (adenine-N6-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine." [EC:2.1.1.55]
synonym: "S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.55]
synonym: "S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.55]
xref: EC:2.1.1.55
xref: MetaCyc:TRNA-ADENINE-N6--METHYLTRANSFERASE-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016426 ! tRNA (adenine)-methyltransferase activity

[Term]
id: GO:0016432
name: tRNA-uridine aminocarboxypropyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine." [EC:2.5.1.25]
synonym: "S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.25]
xref: EC:2.5.1.25
xref: MetaCyc:2.5.1.25-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0016433
name: rRNA (adenine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an adenine residue in an rRNA molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008649 ! rRNA methyltransferase activity

[Term]
id: GO:0016434
name: rRNA (cytosine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a cytosine residue in an rRNA molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008649 ! rRNA methyltransferase activity

[Term]
id: GO:0016435
name: rRNA (guanine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a guanine residue in an rRNA molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008649 ! rRNA methyltransferase activity

[Term]
id: GO:0016436
name: rRNA (uridine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a uridine residue in an rRNA molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008649 ! rRNA methyltransferase activity

[Term]
id: GO:0016437
name: tRNA cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1)." [EC:2.7.7.21]
synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.21]
synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21]
synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21]
synonym: "ATP(CTP):tRNA nucleotidyltransferase activity" EXACT [EC:2.7.7.21]
synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21]
synonym: "CTP:tRNA cytidylyltransferase activity" EXACT []
synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.21]
synonym: "ribonucleic cytidylyltransferase" BROAD [EC:2.7.7.21]
synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.21]
synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.21]
synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [EC:2.7.7.21]
synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [EC:2.7.7.21]
synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.21]
synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [EC:2.7.7.21]
synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.21]
synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.21]
synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.21]
synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.21]
synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.21]
xref: EC:2.7.7.21
xref: MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0016438
name: tRNA-queuosine beta-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose + tRNA(Asp)-queuosine = GDP + tRNA(Asp)-O-5''-beta-D-mannosylqueuosine." [EC:2.4.1.110]
synonym: "GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.110]
xref: EC:2.4.1.110
xref: MetaCyc:2.4.1.110-RXN
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0016441
name: posttranscriptional gene silencing
namespace: biological_process
def: "The inactivation of gene expression by a posttranscriptional mechanism." [GOC:mah, PMID:15020054]
synonym: "cosuppression" RELATED []
synonym: "PTGS" EXACT []
synonym: "quelling" EXACT []
xref: Wikipedia:Post_transcriptional_gene_silencing
is_a: GO:0010608 ! posttranscriptional regulation of gene expression
is_a: GO:0016458 ! gene silencing
is_a: GO:0040029 ! regulation of gene expression, epigenetic

[Term]
id: GO:0016442
name: RNA-induced silencing complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]
synonym: "RISC complex" EXACT []
xref: Wikipedia:RNA-induced_silencing_complex
is_a: GO:0031332 ! RNAi effector complex

[Term]
id: GO:0016443
name: bidentate ribonuclease III activity
namespace: molecular_function
def: "Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference." [PMID:15242644]
synonym: "bidentate RNase III activity" EXACT []
xref: EC:3.1.26.-
is_a: GO:0004525 ! ribonuclease III activity

[Term]
id: GO:0016444
name: somatic cell DNA recombination
namespace: biological_process
def: "Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma]
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0016445
name: somatic diversification of immunoglobulins
namespace: biological_process
def: "The somatic process by means of which sequence diversity of immunoglobulins is generated." [GOC:add, GOC:ma, ISBN:0781735149 "Fundamental Immunology"]
synonym: "somatic diversification of antibodies" EXACT []
is_a: GO:0002200 ! somatic diversification of immune receptors
relationship: part_of GO:0002377 ! immunoglobulin production

[Term]
id: GO:0016446
name: somatic hypermutation of immunoglobulin genes
namespace: biological_process
def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11205330, PMID:11205333, PMID:14975236, PMID:7813007]
synonym: "somatic hypermutation of antibody genes" EXACT []
is_a: GO:0002566 ! somatic diversification of immune receptors via somatic mutation
is_a: GO:0016445 ! somatic diversification of immunoglobulins

[Term]
id: GO:0016447
name: somatic recombination of immunoglobulin gene segments
namespace: biological_process
def: "The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "somatic recombination of antibody gene segments" EXACT []
is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus
is_a: GO:0016445 ! somatic diversification of immunoglobulins

[Term]
id: GO:0016453
name: C-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
is_a: GO:0016407 ! acetyltransferase activity
is_a: GO:0016408 ! C-acyltransferase activity

[Term]
id: GO:0016454
name: C-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0016408 ! C-acyltransferase activity
is_a: GO:0016409 ! palmitoyltransferase activity

[Term]
id: GO:0016455
name: RNA polymerase II transcription mediator activity
namespace: molecular_function
def: "Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex." [GOC:ma]
synonym: "thyroid receptor-associated protein" RELATED []
synonym: "TRAP protein" RELATED []
is_a: GO:0016251 ! general RNA polymerase II transcription factor activity

[Term]
id: GO:0016456
name: X chromosome located dosage compensation complex, transcription activating
namespace: cellular_component
def: "An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster." [GOC:ma, GOC:mtg_sensu]
synonym: "dosage compensation complex" BROAD []
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0046536 ! dosage compensation complex
relationship: part_of GO:0000805 ! X chromosome

[Term]
id: GO:0016457
name: dosage compensation complex assembly during dosage compensation by hyperactivation of X chromosome
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on the X chromosome of the heterogametic sex, ultimately resulting in a two-fold increase in transcription from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl]
is_a: GO:0042714 ! dosage compensation complex assembly
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0009047 ! dosage compensation, by hyperactivation of X chromosome

[Term]
id: GO:0016458
name: gene silencing
namespace: biological_process
def: "Any transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:jic, GOC:tb]
comment: Note that this process is the opposite of long-term maintenance of gene activation.
subset: goslim_pir
synonym: "long-term maintenance of gene inactivation" RELATED []
xref: Wikipedia:Gene_silencing
is_a: GO:0009987 ! cellular process
is_a: GO:0010629 ! negative regulation of gene expression

[Term]
id: GO:0016459
name: myosin complex
namespace: cellular_component
def: "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0016460
name: myosin II complex
namespace: cellular_component
def: "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]
synonym: "conventional myosin" RELATED []
is_a: GO:0016459 ! myosin complex

[Term]
id: GO:0016461
name: unconventional myosin complex
namespace: cellular_component
alt_id: GO:0005860
def: "A portmanteau term for myosins other than myosin II." [GOC:ma]
comment: Note that this term is retained because it is widely used by biologists.
synonym: "non-muscle myosin" RELATED []
is_a: GO:0016459 ! myosin complex

[Term]
id: GO:0016462
name: pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [EC:3.6.1.-, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
xref: EC:3.6.1.-
xref: Reactome:3222 "pyrophosphatase activity"
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0016463
name: zinc-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) = ADP + phosphate + Zn2+(out)." [EC:3.6.3.5]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "AtHMA4" RELATED [EC:3.6.3.5]
synonym: "ATP phosphohydrolase (Zn2+-exporting)" EXACT [EC:3.6.3.5]
synonym: "P(1B)-type ATPase activity" NARROW [EC:3.6.3.5]
synonym: "P1B-type ATPase activity" EXACT [EC:3.6.3.5]
synonym: "zinc exporting ATPase activity" EXACT []
synonym: "zinc-translocating P-type ATPase activity" BROAD [EC:3.6.3.5]
synonym: "Zn(2+)-exporting ATPase activity" EXACT [EC:3.6.3.5]
synonym: "Zn(II)-translocating P-type ATPase activity" EXACT [EC:3.6.3.5]
synonym: "Zn2+-exporting ATPase activity" EXACT [EC:3.6.3.5]
synonym: "zn2+-exporting ATPase activity" EXACT [EC:3.6.3.5]
xref: EC:3.6.3.5
xref: MetaCyc:3.6.3.5-RXN
is_a: GO:0005385 ! zinc ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

[Term]
id: GO:0016464
name: chloroplast protein-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma." [EC:3.6.3.52]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ATP phosphohydrolase (chloroplast protein-importing)" EXACT [EC:3.6.3.52]
synonym: "chloroplast protein ABC transporter" NARROW []
xref: EC:3.6.3.52
xref: MetaCyc:3.6.3.52-RXN
is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity

[Term]
id: GO:0016465
name: chaperonin ATPase complex
namespace: cellular_component
def: "Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0016466
name: hydrogen-translocating A-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in archae." [TC:3.A.2.3.1]
comment: This term was made obsolete because it represents a gene product.
synonym: "proton-translocating A-type ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0046961

[Term]
id: GO:0016467
name: hydrogen-translocating F-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.1, TC:3.A.2.1.3]
comment: This term was made obsolete because it represents a gene product.
synonym: "ATP synthase" BROAD []
synonym: "F1-ATPase activity" EXACT []
synonym: "proton-translocating F-type ATPase activity" EXACT []
is_obsolete: true
replaced_by: GO:0046933
replaced_by: GO:0046961

[Term]
id: GO:0016468
name: sodium-translocating F-type ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.2]
comment: This term was made obsolete because it represents a gene product.
synonym: "ATP synthase" BROAD []
is_obsolete: true
replaced_by: GO:0046932
replaced_by: GO:0046962

[Term]
id: GO:0016469
name: proton-transporting two-sector ATPase complex
namespace: cellular_component
def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483]
subset: goslim_pir
subset: gosubset_prok
synonym: "hydrogen-transporting two-sector ATPase complex" EXACT []
synonym: "vacuolar hydrogen-transporting ATPase" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0016471
name: vacuolar proton-transporting V-type ATPase complex
namespace: cellular_component
def: "A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]
comment: See also the cellular component terms 'vacuolar proton-transporting V-type ATPase, V1 domain ; GO:0000221' and 'vacuolar proton-transporting V-type ATPase, V0 domain ; GO:0000220' and the molecular function term 'hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961'.
subset: gosubset_prok
synonym: "vacuolar hydrogen-translocating V-type ATPase complex" EXACT []
is_a: GO:0033176 ! proton-transporting V-type ATPase complex
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0016472
name: sodium ion-transporting two-sector ATPase complex
namespace: cellular_component
def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis." [GOC:mah, PMID:14656431]
subset: goslim_pir
synonym: "sodium-transporting two-sector ATPase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0016021 ! integral to membrane

[Term]
id: GO:0016473
name: sodium ion-transporting F-type ATPase complex
namespace: cellular_component
def: "A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism." [GOC:mah, PMID:14656431]
synonym: "sodium-translocating F-type ATPase complex" EXACT []
is_a: GO:0016472 ! sodium ion-transporting two-sector ATPase complex

[Term]
id: GO:0016474
name: sodium ion-transporting V-type ATPase complex
namespace: cellular_component
def: "A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis." [GOC:mah, PMID:15802565]
synonym: "sodium-translocating V-type ATPase complex" EXACT []
is_a: GO:0016472 ! sodium ion-transporting two-sector ATPase complex

[Term]
id: GO:0016475
name: detection of nuclear:cytoplasmic ratio
namespace: biological_process
def: "The process by which the size of the nucleus with respect to its cytoplasm is sensed by a cell." [GOC:jl]
synonym: "interpretation of nuclear:cytoplasmic ratio" EXACT []
synonym: "sensing of nuclear:cytoplasmic ratio" EXACT []
is_a: GO:0009726 ! detection of endogenous stimulus
relationship: part_of GO:0016049 ! cell growth

[Term]
id: GO:0016476
name: regulation of embryonic cell shape
namespace: biological_process
def: "Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb]
synonym: "shape changes of embryonic cells" RELATED [GOC:dph, GOC:tb]
is_a: GO:0008360 ! regulation of cell shape
is_a: GO:0045995 ! regulation of embryonic development

[Term]
id: GO:0016477
name: cell migration
namespace: biological_process
def: "The orderly movement of a cell from one site to another, often during the development of a multicellular organism or multicellular structure." [GOC:ems, GOC:pf]
xref: Wikipedia:Cell_migration
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0016479
name: negative regulation of transcription from RNA polymerase I promoter
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter." [GOC:go_curators]
synonym: "down regulation of transcription from RNA polymerase I promoter" EXACT []
synonym: "down-regulation of transcription from RNA polymerase I promoter" EXACT []
synonym: "downregulation of transcription from RNA polymerase I promoter" EXACT []
synonym: "inhibition of transcription from RNA polymerase I promoter" NARROW []
synonym: "negative regulation of transcription from Pol I promoter" EXACT []
is_a: GO:0006356 ! regulation of transcription from RNA polymerase I promoter
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent
relationship: negatively_regulates GO:0006360 ! transcription from RNA polymerase I promoter

[Term]
id: GO:0016480
name: negative regulation of transcription from RNA polymerase III promoter
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter." [GOC:go_curators]
synonym: "down regulation of transcription from RNA polymerase III promoter" EXACT []
synonym: "down-regulation of transcription from RNA polymerase III promoter" EXACT []
synonym: "downregulation of transcription from RNA polymerase III promoter" EXACT []
synonym: "inhibition of transcription from RNA polymerase III promoter" NARROW []
synonym: "negative regulation of transcription from Pol III promoter" EXACT []
is_a: GO:0006359 ! regulation of transcription from RNA polymerase III promoter
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent
relationship: negatively_regulates GO:0006383 ! transcription from RNA polymerase III promoter

[Term]
id: GO:0016481
name: negative regulation of transcription
namespace: biological_process
alt_id: GO:0061021
def: "Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of transcription" EXACT []
synonym: "down-regulation of transcription" EXACT []
synonym: "downregulation of transcription" EXACT []
synonym: "inhibition of transcription" NARROW []
synonym: "negative regulation of cellular transcription" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045449 ! regulation of transcription
is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
relationship: negatively_regulates GO:0006350 ! transcription

[Term]
id: GO:0016482
name: cytoplasmic transport
namespace: biological_process
def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell." [GOC:ai]
synonym: "cytoplasmic streaming" NARROW []
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0016483
name: tryptophan hydroxylase activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme tryptophase hydroxylase." [GOC:ai]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0016484
name: proprotein convertase 2 activator activity
namespace: molecular_function
def: "OBSOLETE. Required for the maturation and activation of proprotein convertase 2." [GOC:ma, PMID:10749852]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
is_obsolete: true
consider: GO:0016504

[Term]
id: GO:0016485
name: protein processing
namespace: biological_process
def: "Any protein maturation process achieved by the cleavage of peptide bonds." [GOC:curators, GOC:jl, GOC:jsg]
subset: gosubset_prok
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0016486
name: peptide hormone processing
namespace: biological_process
def: "The generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:mah]
is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0051605 ! protein maturation by peptide bond cleavage

[Term]
id: GO:0016487
name: farnesol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators]
subset: gosubset_prok
synonym: "farnesol metabolism" EXACT []
is_a: GO:0006714 ! sesquiterpenoid metabolic process
is_a: GO:0034308 ! monohydric alcohol metabolic process

[Term]
id: GO:0016488
name: farnesol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators]
subset: gosubset_prok
synonym: "farnesol breakdown" EXACT []
synonym: "farnesol catabolism" EXACT []
synonym: "farnesol degradation" EXACT []
is_a: GO:0016107 ! sesquiterpenoid catabolic process
is_a: GO:0016487 ! farnesol metabolic process
is_a: GO:0034310 ! monohydric alcohol catabolic process

[Term]
id: GO:0016490
name: structural constituent of peritrophic membrane
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "structural constituent of peritrophic matrix" RELATED []
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0016491
name: oxidoreductase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]
comment: Note that enzymes of class EC:1.97.-.- should also be annotated to this term.
subset: goslim_candida
subset: goslim_goa
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on other substrates" NARROW []
synonym: "redox activity" EXACT []
xref: EC:1
xref: Reactome:95 "oxidoreductase activity"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016492
name: neurotensin receptor activity, G-protein coupled
namespace: molecular_function
def: "Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state." [PMID:10390649]
synonym: "G protein coupled neurotensin receptor activity" EXACT []
synonym: "G-protein coupled neurotensin receptor activity" EXACT []
synonym: "G-protein-coupled neurotensin receptor activity" EXACT []
synonym: "neurotensin receptor activity, G protein coupled" EXACT []
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0016493
name: C-C chemokine receptor activity
namespace: molecular_function
def: "Combining with a C-C chemokine to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [PMID:8662823]
is_a: GO:0004950 ! chemokine receptor activity
is_a: GO:0019957 ! C-C chemokine binding

[Term]
id: GO:0016494
name: C-X-C chemokine receptor activity
namespace: molecular_function
def: "Combining with a C-X-C chemokine to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif." [PMID:8662823]
is_a: GO:0004950 ! chemokine receptor activity
is_a: GO:0019958 ! C-X-C chemokine binding

[Term]
id: GO:0016495
name: C-X3-C chemokine receptor activity
namespace: molecular_function
def: "Combining with a C-X3-C chemokine to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:dph]
is_a: GO:0004950 ! chemokine receptor activity
is_a: GO:0019960 ! C-X3-C chemokine binding

[Term]
id: GO:0016496
name: substance P receptor activity
namespace: molecular_function
def: "Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0004995 ! tachykinin receptor activity

[Term]
id: GO:0016497
name: substance K receptor activity
namespace: molecular_function
def: "Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "neurokinin A receptor activity" EXACT []
synonym: "neuromedin L receptor activity" EXACT []
is_a: GO:0004995 ! tachykinin receptor activity

[Term]
id: GO:0016498
name: neuromedin K receptor activity
namespace: molecular_function
def: "Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "neurokinin B receptor activity" EXACT []
is_a: GO:0004995 ! tachykinin receptor activity

[Term]
id: GO:0016499
name: orexin receptor activity
namespace: molecular_function
def: "Combining with orexin to initiate a change in cell activity." [GOC:ai]
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0016500
name: protein-hormone receptor activity
namespace: molecular_function
def: "Combining with a protein hormone to initiate a change in cell activity." [GOC:mah]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0016501
name: prostacyclin receptor activity
namespace: molecular_function
alt_id: GO:0004959
def: "Combining with prostacyclin (PGI(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "PGI receptor activity" RELATED []
synonym: "PGI(2) receptor activity" EXACT []
synonym: "prostaglandin I receptor activity" EXACT []
is_a: GO:0004955 ! prostaglandin receptor activity

[Term]
id: GO:0016502
name: nucleotide receptor activity
namespace: molecular_function
def: "Combining with a nucleotide to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0016503
name: pheromone receptor activity
namespace: molecular_function
def: "Combining with a pheromone to initiate a change in cell activity." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0016504
name: peptidase activator activity
namespace: molecular_function
def: "Increases the activity of a peptidase, any enzyme catalyzes the hydrolysis peptide bonds." [GOC:ai]
subset: gosubset_prok
synonym: "protease activator activity" EXACT [GOC:mah]
xref: Reactome:11526 "peptidase activator activity"
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0016505
name: apoptotic protease activator activity
namespace: molecular_function
is_a: GO:0016504 ! peptidase activator activity

[Term]
id: GO:0016506
name: apoptosis activator activity
namespace: molecular_function
def: "OBSOLETE. The function held by products which directly activate any step in the process of apoptosis." [GOC:hb]
comment: This term was made obsolete because it represents involvement in a biological process.
is_obsolete: true
replaced_by: GO:0006917

[Term]
id: GO:0016507
name: fatty acid beta-oxidation multienzyme complex
namespace: cellular_component
def: "A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix." [GOC:ma]
synonym: "trifunctional enzyme" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0016508
name: long-chain-enoyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.74]
synonym: "long-chain enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.74]
synonym: "long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.74]
xref: EC:4.2.1.74
xref: MetaCyc:LONG-CHAIN-ENOYL-COA-HYDRATASE-RXN
xref: Reactome:25675 "long-chain-enoyl-CoA hydratase activity"
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0016509
name: long-chain-3-hydroxyacyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+. Acts most rapidly on derivatives with chain length 8 or 10." [EC:1.1.1.211]
comment: Also see '3-hydroxyacyl-CoA dehydrogenase activity ; GO:0003857'.
subset: gosubset_prok
synonym: "beta-hydroxyacyl-CoA dehydrogenase activity" EXACT [EC:1.1.1.211]
synonym: "LCHAD" RELATED [EC:1.1.1.211]
synonym: "long-chain 3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.211]
synonym: "long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.211]
xref: EC:1.1.1.211
xref: MetaCyc:1.1.1.211-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016511
name: endothelin-converting enzyme activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0016512
name: endothelin-converting enzyme 1 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor." [EC:3.4.24.71]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "ECE-1 activity" EXACT [EC:3.4.24.71]
xref: EC:3.4.24.71
xref: MetaCyc:3.4.24.71-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0016513
name: core-binding factor complex
namespace: cellular_component
def: "A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit." [PMID:15156179, PMID:8497254]
synonym: "AML1 complex" NARROW []
synonym: "CBF complex" EXACT []
synonym: "PEPB2 complex" NARROW []
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0016514
name: SWI/SNF complex
namespace: cellular_component
def: "A SWI/SNF-type complex that contains nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components." [GOC:mah, PMID:12672490]
synonym: "SWI-SNF complex" EXACT [GOC:mah]
is_a: GO:0070603 ! SWI/SNF-type complex

[Term]
id: GO:0016515
name: interleukin-13 receptor activity
namespace: molecular_function
def: "Combining with interleukin-13 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-13 receptor activity" EXACT [GOC:mah]
synonym: "IL-13R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0019973 ! interleukin-13 binding

[Term]
id: GO:0016516
name: interleukin-4 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-4 (IL-4) and consists of an alpha chain that binds IL-4 with high affinity and a gamma common chain that also forms part of the interleukin-2 receptor." [PMID:10358772]
synonym: "IL-4 receptor complex" EXACT [GOC:add]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0016517
name: interleukin-12 receptor activity
namespace: molecular_function
def: "Combining with interleukin-12 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-12 receptor activity" EXACT [GOC:mah]
synonym: "IL-12R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0019972 ! interleukin-12 binding

[Term]
id: GO:0016518
name: interleukin-14 receptor activity
namespace: molecular_function
def: "Combining with interleukin-14 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-14 receptor activity" EXACT [GOC:mah]
synonym: "IL-14R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0019974 ! interleukin-14 binding

[Term]
id: GO:0016519
name: gastric inhibitory peptide receptor activity
namespace: molecular_function
def: "Combining with gastric inhibitory peptide to initiate a change in cell activity." [GOC:mah, PMID:8243312]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0016520
name: growth hormone-releasing hormone receptor activity
namespace: molecular_function
def: "Combining with growth hormone-releasing hormone to initiate a change in cell activity." [PMID:12529933]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0016521
name: pituitary adenylate cyclase activating polypeptide activity
namespace: molecular_function
synonym: "pituitary adenylyl cyclase activating polypeptide activity" EXACT []
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0016524
name: latrotoxin receptor activity
namespace: molecular_function
def: "Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, to initiate a change in cell activity." [GOC:jl, PMID:10025961]
synonym: "latrophilin" NARROW []
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0016525
name: negative regulation of angiogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators]
synonym: "down regulation of angiogenesis" EXACT []
synonym: "down-regulation of angiogenesis" EXACT []
synonym: "downregulation of angiogenesis" EXACT []
synonym: "inhibition of angiogenesis" NARROW []
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0001525 ! angiogenesis

[Term]
id: GO:0016527
name: brain-specific angiogenesis inhibitor activity
namespace: molecular_function
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0016528
name: sarcoplasm
namespace: cellular_component
def: "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum." [ISBN:0198547684]
xref: Wikipedia:Sarcoplasm
is_a: GO:0005737 ! cytoplasm

[Term]
id: GO:0016529
name: sarcoplasmic reticulum
namespace: cellular_component
alt_id: GO:0008221
def: "A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage." [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684]
comment: See also the cellular component terms 'sarcoplasm ; GO:0016528', 'nuclear envelope ; GO:0005635' and 'endoplasmic reticulum ; GO:0005783'.
xref: Wikipedia:Endoplasmic_reticulum#Sarcoplasmic_reticulum
is_a: GO:0005783 ! endoplasmic reticulum
is_a: GO:0071212 ! subsynaptic reticulum
relationship: part_of GO:0016528 ! sarcoplasm

[Term]
id: GO:0016530
name: metallochaperone activity
namespace: molecular_function
def: "Assists in the delivery of metal ions to target proteins or compartments." [GOC:jl, PMID:11739376]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0016531
name: copper chaperone activity
namespace: molecular_function
def: "Assists in the delivery of copper ions to target proteins or compartments." [PMID:10790544, PMID:11739376]
is_a: GO:0005507 ! copper ion binding
is_a: GO:0016530 ! metallochaperone activity

[Term]
id: GO:0016532
name: superoxide dismutase copper chaperone activity
namespace: molecular_function
def: "A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase." [http://link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html, PMID:9295278]
comment: See also the molecular function term 'superoxide dismutase activity ; GO:0004784'.
is_a: GO:0016531 ! copper chaperone activity

[Term]
id: GO:0016533
name: cyclin-dependent protein kinase 5 holoenzyme complex
namespace: cellular_component
def: "A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits." [PMID:15689152]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0016534
name: cyclin-dependent protein kinase 5 activator activity
namespace: molecular_function
alt_id: GO:0016535
def: "Increases the activity of cyclin-dependent protein kinase 5." [GOC:mah]
synonym: "cyclin-dependent protein kinase 5 activator, intrinsic catalyst activity" EXACT []
is_a: GO:0043539 ! protein serine/threonine kinase activator activity

[Term]
id: GO:0016536
name: cyclin-dependent protein kinase 5 activator regulator activity
namespace: molecular_function
def: "Modulation of the activity of cyclin-dependent protein kinase 5 activator." [GOC:ai]
synonym: "cyclin-dependent protein kinase 5 activator, intrinsic regulator activity" NARROW []
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0016538
name: cyclin-dependent protein kinase regulator activity
namespace: molecular_function
alt_id: GO:0003751
alt_id: GO:0003752
alt_id: GO:0003753
def: "Modulates the activity of a cyclin-dependent protein kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:rn, PMID:7877684, PMID:9442875]
synonym: "cyclin" BROAD []
synonym: "cyclin-dependent protein kinase, intrinsic regulator activity" NARROW []
synonym: "G1/S-specific cyclin" NARROW []
synonym: "G2/M-specific cyclin" NARROW []
xref: EC:2.7.1.-
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0016539
name: intein-mediated protein splicing
namespace: biological_process
def: "The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]
subset: gosubset_prok
synonym: "intein" RELATED []
is_a: GO:0030908 ! protein splicing

[Term]
id: GO:0016540
name: protein autoprocessing
namespace: biological_process
def: "Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]
subset: gosubset_prok
is_a: GO:0016485 ! protein processing

[Term]
id: GO:0016541
name: intein
namespace: molecular_function
def: "OBSOLETE. Intervening protein sequence excised from a protein precursor in protein splicing; inteins catalyze their own excision and many also possess endonuclease activity." [GOC:mah, http://www.neb.com/neb/inteins.html, PMID:8165123]
comment: This term was made obsolete because it refers to a protein sequence feature.
is_obsolete: true
consider: GO:0004519
consider: GO:0016539

[Term]
id: GO:0016543
name: male courtship behavior, orientation prior to leg tapping and wing vibration
namespace: biological_process
def: "The process during courtship, where the male orients towards a potential partner. An example of this is found in Drosophila melanogaster." [GOC:sensu, PMID:11092827]
synonym: "male courtship behavior, orientation" RELATED []
synonym: "male courtship behaviour, orientation" RELATED []
synonym: "male courtship behaviour, orientation prior to leg tapping and wing vibration" RELATED []
is_a: GO:0008049 ! male courtship behavior

[Term]
id: GO:0016544
name: male courtship behavior, tapping to detect pheromone
namespace: biological_process
def: "The process during courtship where the male insect taps the female with his frontal leg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827]
synonym: "male courtship behavior, tapping" RELATED []
synonym: "male courtship behaviour, tapping" EXACT []
synonym: "male courtship behaviour, tapping to detect pheromone" RELATED []
is_a: GO:0008049 ! male courtship behavior

[Term]
id: GO:0016545
name: male courtship behavior, veined wing vibration
namespace: biological_process
def: "The process during courtship where the male insect vibrates his wings. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827]
synonym: "male courtship behavior, wing vibration" RELATED []
synonym: "male courtship behaviour, veined wing vibration" EXACT []
synonym: "male courtship behaviour, wing vibration" RELATED []
is_a: GO:0048065 ! male courtship behavior, veined wing extension

[Term]
id: GO:0016546
name: male courtship behavior, proboscis-mediated licking
namespace: biological_process
def: "The process during courtship where the male fly licks the genitalia of a stationary female fly with his proboscis. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827]
synonym: "male courtship behavior, licking" RELATED []
synonym: "male courtship behaviour, licking" RELATED []
synonym: "male courtship behaviour, proboscis-mediated licking" EXACT []
is_a: GO:0008049 ! male courtship behavior

[Term]
id: GO:0016550
name: insertion or deletion editing
namespace: biological_process
def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during or after transcription." [PMID:11092837]
comment: This term was made obsolete because it represents two separate processes (insertion and deletion).
synonym: "insertion/deletion editing" EXACT []
is_obsolete: true
consider: GO:0070705
consider: GO:0070706

[Term]
id: GO:0016551
name: posttranscriptional insertion or deletion editing
namespace: biological_process
def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place after transcription." [PMID:11092837]
comment: This term was made obsolete because it represents two separate processes (insertion and deletion).
synonym: "posttranscriptional insertion/deletion editing" EXACT []
is_obsolete: true
consider: GO:0070705
consider: GO:0070706

[Term]
id: GO:0016552
name: cotranscriptional insertion or deletion editing
namespace: biological_process
def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during transcription." [PMID:11092837]
comment: This term was made obsolete because it represents two separate processes (insertion and deletion).
synonym: "cotranscriptional insertion/deletion editing" EXACT []
is_obsolete: true
consider: GO:0070705
consider: GO:0070706

[Term]
id: GO:0016553
name: base conversion or substitution editing
namespace: biological_process
def: "Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s)." [PMID:11092837]
subset: gosubset_prok
synonym: "base conversion/substitution editing" EXACT []
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0016554
name: cytidine to uridine editing
namespace: biological_process
def: "The conversion of a cytosine residue to uridine in an RNA molecule by deamination." [PMID:11092837]
subset: gosubset_prok
xref: Reactome:448900 "mRNA Editing: C to U Conversion"
xref: Reactome:470017 "mRNA Editing: C to U Conversion"
xref: Reactome:487718 "mRNA Editing: C to U Conversion"
xref: Reactome:507669 "mRNA Editing: C to U Conversion"
xref: Reactome:72200 "mRNA Editing: C to U Conversion"
is_a: GO:0016553 ! base conversion or substitution editing

[Term]
id: GO:0016555
name: uridine to cytidine editing
namespace: biological_process
def: "The conversion of a uridine residue to cytosine in an RNA molecule by amination." [PMID:11092837]
subset: gosubset_prok
is_a: GO:0016553 ! base conversion or substitution editing

[Term]
id: GO:0016556
name: mRNA modification
namespace: biological_process
alt_id: GO:0006381
def: "The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]
comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'.
subset: gosubset_prok
synonym: "mRNA editing" EXACT []
xref: Reactome:448901 "mRNA Editing"
xref: Reactome:470018 "mRNA Editing"
xref: Reactome:487719 "mRNA Editing"
xref: Reactome:507670 "mRNA Editing"
xref: Reactome:517615 "mRNA Editing"
xref: Reactome:526465 "mRNA Editing"
xref: Reactome:531269 "mRNA Editing"
xref: Reactome:536649 "mRNA Editing"
xref: Reactome:542378 "mRNA Editing"
xref: Reactome:547723 "mRNA Editing"
xref: Reactome:557919 "mRNA Editing"
xref: Reactome:568531 "mRNA Editing"
xref: Reactome:581743 "mRNA Editing"
xref: Reactome:585869 "mRNA Editing"
xref: Reactome:75072 "mRNA Editing"
is_a: GO:0009451 ! RNA modification
is_a: GO:0016071 ! mRNA metabolic process

[Term]
id: GO:0016557
name: peroxisome membrane biogenesis
namespace: biological_process
def: "The process by which a peroxisome membrane is synthesized, aggregates, and bonds together." [GOC:mah]
is_a: GO:0044091 ! membrane biogenesis
relationship: part_of GO:0007031 ! peroxisome organization

[Term]
id: GO:0016558
name: protein import into peroxisome matrix
namespace: biological_process
def: "The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported." [ISBN:0716731363, PMID:11687502, PMID:11988772]
synonym: "peroxisome matrix protein import" EXACT []
synonym: "protein transport to peroxisome matrix" EXACT []
is_a: GO:0006625 ! protein targeting to peroxisome
is_a: GO:0017038 ! protein import

[Term]
id: GO:0016559
name: peroxisome fission
namespace: biological_process
def: "The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507]
synonym: "peroxisome division" EXACT []
synonym: "peroxisome proliferation" EXACT []
is_a: GO:0048285 ! organelle fission
relationship: part_of GO:0007031 ! peroxisome organization

[Term]
id: GO:0016560
name: protein import into peroxisome matrix, docking
namespace: biological_process
def: "The process by which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the preoxisomal membrane." [PMID:11687502, PMID:11988772, PMID:14754507]
synonym: "peroxisome matrix protein import, docking" EXACT []
synonym: "peroxisome receptor docking" RELATED []
synonym: "protein docking during peroxisome matrix protein import" EXACT []
synonym: "protein docking during protein import into peroxisome matrix" EXACT []
synonym: "protein docking during protein transport into peroxisome matrix" EXACT []
synonym: "protein transport into peroxisome matrix, docking" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0016558 ! protein import into peroxisome matrix

[Term]
id: GO:0016561
name: protein import into peroxisome matrix, translocation
namespace: biological_process
def: "The process by which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation." [PMID:11687502]
synonym: "peroxisome matrix protein import, translocation" EXACT []
synonym: "peroxisome receptor translocation" RELATED []
synonym: "protein translocation during peroxisome matrix protein import" EXACT []
synonym: "protein translocation during protein import into peroxisome matrix" EXACT []
synonym: "protein translocation during protein transport into peroxisome matrix" EXACT []
synonym: "protein transport into peroxisome matrix, translocation" EXACT []
is_a: GO:0065002 ! intracellular protein transmembrane transport
relationship: part_of GO:0016558 ! protein import into peroxisome matrix

[Term]
id: GO:0016562
name: protein import into peroxisome matrix, receptor recycling
namespace: biological_process
def: "The process by which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol." [PMID:11687502]
synonym: "peroxisome matrix protein import, receptor recycling" EXACT []
synonym: "peroxisome receptor recycling" RELATED []
synonym: "protein transport into peroxisome matrix, receptor recycling" EXACT []
synonym: "PTS receptor recycling" RELATED []
synonym: "receptor recycling during peroxisome matrix protein import" EXACT []
synonym: "receptor recycling during protein import into peroxisome matrix" EXACT []
synonym: "receptor recycling during protein transport into peroxisome matrix" EXACT []
is_a: GO:0001881 ! receptor recycling
relationship: part_of GO:0016558 ! protein import into peroxisome matrix

[Term]
id: GO:0016563
name: transcription activator activity
namespace: molecular_function
alt_id: GO:0003710
def: "Any transcription regulator activity required for initiation or upregulation of transcription." [GOC:jl, ISBN:0124325653]
subset: gosubset_prok
synonym: "transcription activating factor" NARROW []
synonym: "transcriptional activator activity" EXACT []
xref: Reactome:9388 "transcription activator activity"
is_a: GO:0030528 ! transcription regulator activity

[Term]
id: GO:0016564
name: transcription repressor activity
namespace: molecular_function
def: "Any transcription regulator activity that prevents or downregulates transcription." [GOC:mah]
subset: gosubset_prok
synonym: "negative transcriptional regulator activity" EXACT []
synonym: "transcriptional repressor activity" EXACT []
is_a: GO:0030528 ! transcription regulator activity

[Term]
id: GO:0016565
name: general transcriptional repressor activity
namespace: molecular_function
def: "Any activity that stops or downregulates transcription of genes globally, and is not specific to a particular gene or gene set." [GOC:mah]
is_a: GO:0016564 ! transcription repressor activity

[Term]
id: GO:0016566
name: specific transcriptional repressor activity
namespace: molecular_function
def: "Any activity that stops or downregulates transcription of specific genes or sets of genes." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016564 ! transcription repressor activity

[Term]
id: GO:0016567
name: protein ubiquitination
namespace: biological_process
def: "The process by which one or more ubiquitin moieties are added to a protein." [GOC:ai]
synonym: "protein ubiquitinylation" EXACT []
synonym: "protein ubiquitylation" EXACT []
is_a: GO:0032446 ! protein modification by small protein conjugation
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0016568
name: chromatin modification
namespace: biological_process
def: "The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure." [GOC:mah]
subset: goslim_pombe
is_a: GO:0006325 ! chromatin organization

[Term]
id: GO:0016569
name: covalent chromatin modification
namespace: biological_process
def: "The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups." [GOC:mah]
is_a: GO:0016568 ! chromatin modification

[Term]
id: GO:0016570
name: histone modification
namespace: biological_process
def: "The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc]
xref: Wikipedia:Histone#Histone_modifications_in_chromatin_regulation
is_a: GO:0016569 ! covalent chromatin modification
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0016571
name: histone methylation
namespace: biological_process
def: "The modification of histones by addition of methyl groups." [GOC:ai]
xref: Wikipedia:Histone_methylation
is_a: GO:0006479 ! protein amino acid methylation
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0016572
name: histone phosphorylation
namespace: biological_process
def: "The modification of histones by addition of phosphate groups." [GOC:ai]
is_a: GO:0006468 ! protein amino acid phosphorylation
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0016573
name: histone acetylation
namespace: biological_process
def: "The modification of a histone by the addition of an acetyl group." [GOC:ai]
is_a: GO:0006473 ! protein amino acid acetylation
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0016574
name: histone ubiquitination
namespace: biological_process
def: "The modification of histones by addition of ubiquitin groups." [GOC:ai]
synonym: "histone ubiquitinylation" EXACT []
synonym: "histone ubiquitylation" EXACT []
is_a: GO:0016567 ! protein ubiquitination
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0016575
name: histone deacetylation
namespace: biological_process
def: "The modification of histones by removal of acetyl groups." [GOC:ai]
is_a: GO:0006476 ! protein amino acid deacetylation
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0016576
name: histone dephosphorylation
namespace: biological_process
def: "The modification of histones by removal of phosphate groups." [GOC:ai]
is_a: GO:0006470 ! protein amino acid dephosphorylation
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0016577
name: histone demethylation
namespace: biological_process
def: "The modification of histones by removal of methyl groups." [GOC:ai]
is_a: GO:0006482 ! protein amino acid demethylation
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0016578
name: histone deubiquitination
namespace: biological_process
def: "The modification of histones by removal of ubiquitin groups." [GOC:ai]
synonym: "histone deubiquitinylation" EXACT []
synonym: "histone deubiquitylation" EXACT []
is_a: GO:0016570 ! histone modification
is_a: GO:0016579 ! protein deubiquitination

[Term]
id: GO:0016579
name: protein deubiquitination
namespace: biological_process
alt_id: GO:0006514
def: "The removal of one or more ubiquitin moieties from a protein." [GOC:ai]
synonym: "deubiquitination" EXACT []
synonym: "protein deubiquitinylation" EXACT []
synonym: "protein deubiquitylation" EXACT []
is_a: GO:0043687 ! post-translational protein modification
is_a: GO:0070646 ! protein modification by small protein removal

[Term]
id: GO:0016580
name: Sin3 complex
namespace: cellular_component
def: "A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins." [PMID:10589671, PMID:11743021, PMID:12865422]
is_a: GO:0070822 ! Sin3-type complex

[Term]
id: GO:0016581
name: NuRD complex
namespace: cellular_component
def: "An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569]
synonym: "Mi-2 complex" EXACT []
synonym: "NRD complex" EXACT []
synonym: "nucleosome remodeling and histone deacetylation complex" EXACT []
is_a: GO:0000118 ! histone deacetylase complex
is_a: GO:0017053 ! transcriptional repressor complex

[Term]
id: GO:0016582
name: non-covalent chromatin modification
namespace: biological_process
def: "The alteration of DNA or protein in chromatin by the non-covalent addition or removal of chemical groups." [GOC:jl]
is_a: GO:0016568 ! chromatin modification

[Term]
id: GO:0016583
name: nucleosome modeling
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it has been replaced by more specific terms.
is_obsolete: true
consider: GO:0006334

[Term]
id: GO:0016584
name: nucleosome positioning
namespace: biological_process
def: "Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GOC:bf, PMID:11447119, PMID:8676389]
synonym: "nucleosome spacing" EXACT []
is_a: GO:0031497 ! chromatin assembly
is_a: GO:0034728 ! nucleosome organization

[Term]
id: GO:0016585
name: chromatin remodeling complex
namespace: cellular_component
alt_id: GO:0005679
def: "Any complex that mediates dynamic changes in eukaryotic chromatin." [GOC:mah]
subset: goslim_pir
synonym: "chromatin remodelling complex" EXACT []
synonym: "nucleosome remodeling complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0016586
name: RSC complex
namespace: cellular_component
def: "A protein complex similar to, but more abundant than, the Swi/Snf complex. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining." [PMID:11937489, PMID:12672490, PMID:15870268, PMID:8980231]
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0016587
name: ISW1 complex
namespace: cellular_component
def: "A protein complex that contains an ISWI-family ATPase such as Saccharomyces Isw1p, and acts to modify chromatin structure." [GOC:mah, PMID:15020051]
is_a: GO:0031010 ! ISWI complex

[Term]
id: GO:0016589
name: NURF complex
namespace: cellular_component
def: "A four subunit ISWI-containing protein complex that facilitates nucleosome mobility and transcriptional activation in an ATP-dependent manner. In contrast to other chromatin remodeling complexes, the ATPase activity of NURF requires nucleosomes rather than free DNA or histones." [GOC:bf, PMID:10779516, PMID:11279013]
synonym: "nucleosome remodeling factor complex" EXACT []
is_a: GO:0031010 ! ISWI complex

[Term]
id: GO:0016590
name: ACF complex
namespace: cellular_component
def: "A chromatin-remodeling complex that catalyzes the ATP-dependent assembly of periodic nucleosome arrays. In Drosophila, the complex comprises ACF1 and ISWI." [GOC:bf, PMID:12192034]
synonym: "ATP-utilizing chromatin assembly and remodeling factor complex" EXACT []
is_a: GO:0005678 ! chromatin assembly complex

[Term]
id: GO:0016591
name: DNA-directed RNA polymerase II, holoenzyme
namespace: cellular_component
def: "Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA." [GOC:jl, PMID:15196470, Wikipedia:Rna_polymerase_ii]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0016592
name: mediator complex
namespace: cellular_component
alt_id: GO:0000119
def: "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
synonym: "CDK8-containing TRAP/mediator complex" RELATED []
synonym: "L mediator complex" EXACT []
synonym: "Srb-mediator complex" EXACT [GOC:mah]
synonym: "TRAP complex" NARROW []
xref: Wikipedia:Mediator_(coactivator)
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0016593
name: Cdc73/Paf1 complex
namespace: cellular_component
def: "A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586]
synonym: "Paf1 complex" EXACT [GOC:cjk]
synonym: "Paf1p complex" EXACT [GOC:cjk]
is_a: GO:0008023 ! transcription elongation factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0016594
name: glycine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with glycine, aminoethanoic acid." [GOC:ai]
synonym: "aminoacetic acid binding" EXACT []
synonym: "aminoethanoic acid binding" EXACT []
synonym: "Gly binding" EXACT []
is_a: GO:0016597 ! amino acid binding

[Term]
id: GO:0016595
name: glutamate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with glutamate, the anion of 2-aminopentanedioic acid." [GOC:ai]
synonym: "glutamic acid binding" EXACT []
is_a: GO:0016597 ! amino acid binding

[Term]
id: GO:0016596
name: thienylcyclohexylpiperidine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with thienylcyclohexylpiperidine." [GOC:jl]
synonym: "TCP binding" BROAD []
is_a: GO:0008144 ! drug binding

[Term]
id: GO:0016597
name: amino acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0043176 ! amine binding

[Term]
id: GO:0016598
name: protein arginylation
namespace: biological_process
alt_id: GO:0019130
def: "The posttranslational conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [PMID:17896865]
synonym: "protein amino acid arginylation" EXACT []
is_a: GO:0043687 ! post-translational protein modification
relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process

[Term]
id: GO:0016600
name: flotillin complex
namespace: cellular_component
def: "A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae." [PMID:17206938, PMID:17600709]
comment: See also the cellular component term 'caveola ; GO:0005901'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005901 ! caveola

[Term]
id: GO:0016601
name: Rac protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state." [GOC:bf]
synonym: "Rac mediated signal transduction" EXACT []
is_a: GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0016602
name: CCAAT-binding factor complex
namespace: cellular_component
def: "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [PMID:7828851]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0016603
name: glutaminyl-peptide cyclotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3." [EC:2.3.2.5]
subset: gosubset_prok
synonym: "glutaminyl cyclase activity" EXACT [EC:2.3.2.5]
synonym: "glutaminyl-transfer ribonucleate cyclotransferase activity" EXACT [EC:2.3.2.5]
synonym: "glutaminyl-tRNA cyclotransferase activity" NARROW [EC:2.3.2.5]
synonym: "L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.5]
xref: EC:2.3.2.5
xref: MetaCyc:GLUTAMINYL-PEPTIDE-CYCLOTRANSFERASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0016604
name: nuclear body
namespace: cellular_component
def: "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]
xref: NIF_Subcellular:sao505137457
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0016605
name: PML body
namespace: cellular_component
def: "A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection." [GOC:ma, PMID:10944585]
synonym: "ND10" EXACT []
synonym: "nuclear dot" RELATED []
synonym: "PML NB" EXACT []
synonym: "PML nuclear body" EXACT []
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0016606
name: LYSP100-associated nuclear domain
namespace: cellular_component
def: "A nuclear body that is enriched in the lymphoid cell-specific protein LYSp100B; LANDs are globular, electron-dense structures and are morphologically distinct from the annular structures characteristic of PML bodies." [PMID:10921892, PMID:8695863]
synonym: "LANDs" EXACT [PMID:8695863]
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0016607
name: nuclear speck
namespace: cellular_component
def: "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]
synonym: "nuclear speckle" EXACT []
synonym: "nuclear speckles" EXACT []
synonym: "speckle domain" NARROW []
synonym: "speckle focus" RELATED []
synonym: "splicing speckle" EXACT []
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0016608
name: growth hormone-releasing hormone activity
namespace: molecular_function
def: "The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland." [ISBN:0198506732]
synonym: "GHRF activity" EXACT [ISBN:0198506732]
synonym: "GHRH activity" EXACT [ISBN:0198506732]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0016609
name: G-protein coupled serotonin receptor activity
namespace: molecular_function
synonym: "G protein coupled serotonin receptor activity" EXACT []
synonym: "G-protein-coupled serotonin receptor activity" EXACT []
is_a: GO:0004993 ! serotonin receptor activity

[Term]
id: GO:0016610
name: nitrogenase complex
namespace: cellular_component
def: "An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, MetaCyc:CPLX-186, MetaCyc:CPLX-525]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0016611
name: iron-iron nitrogenase complex
namespace: cellular_component
def: "An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, GOC:jl, PMID:11848850]
comment: Note that it is not established whether the nitrogenase exists in vivo in a specific particle or whether the nitrogenase proteins are bound nonspecifically to the membranes of some cells.
subset: gosubset_prok
is_a: GO:0016610 ! nitrogenase complex

[Term]
id: GO:0016612
name: molybdenum-iron nitrogenase complex
namespace: cellular_component
def: "An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1]
subset: gosubset_prok
synonym: "molybdenum-iron nitrogenase activity" RELATED []
is_a: GO:0016610 ! nitrogenase complex

[Term]
id: GO:0016613
name: vanadium-iron nitrogenase complex
namespace: cellular_component
def: "An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1, PMID:3474027]
subset: gosubset_prok
synonym: "vanadium-iron nitrogenase activity" RELATED []
is_a: GO:0016610 ! nitrogenase complex

[Term]
id: GO:0016614
name: oxidoreductase activity, acting on CH-OH group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.1.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" NARROW []
xref: EC:1.1
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016615
name: malate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089]
subset: gosubset_prok
xref: MetaCyc:MALATE-DEH-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016616
name: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]
subset: gosubset_prok
xref: EC:1.1.1
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016617
name: 4-oxoproline reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+." [EC:1.1.1.104]
synonym: "4-hydroxy-L-proline:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.104]
synonym: "hydroxy-L-proline oxidase activity" EXACT []
synonym: "hydroxyproline oxidase activity" EXACT [EC:1.1.1.104]
xref: EC:1.1.1.104
xref: MetaCyc:4-OXOPROLINE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016618
name: hydroxypyruvate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+." [EC:1.1.1.81]
subset: gosubset_prok
synonym: "beta-hydroxypyruvate reductase activity" EXACT [EC:1.1.1.81]
synonym: "D-glycerate dehydrogenase activity" EXACT [EC:1.1.1.81]
synonym: "D-glycerate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.81]
synonym: "NADH:hydroxypyruvate reductase activity" EXACT [EC:1.1.1.81]
xref: EC:1.1.1.81
xref: MetaCyc:HYDROXYPYRUVATE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016619
name: malate dehydrogenase (oxaloacetate-decarboxylating) activity
namespace: molecular_function
alt_id: GO:0004472
def: "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Also decarboxylates oxaloacetate." [EC:1.1.1.38]
subset: gosubset_prok
synonym: "'malic' enzyme" RELATED [EC:1.1.1.38]
synonym: "(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [EC:1.1.1.38]
synonym: "NAD-linked malic enzyme" RELATED [EC:1.1.1.38]
synonym: "NAD-malic enzyme activity" BROAD [EC:1.1.1.38]
synonym: "NAD-specific malic enzyme" RELATED [EC:1.1.1.38]
xref: EC:1.1.1.38
xref: MetaCyc:MALIC-NAD-RXN
is_a: GO:0004470 ! malic enzyme activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016620
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
subset: gosubset_prok
xref: EC:1.2.1
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0016621
name: cinnamoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+." [EC:1.2.1.44]
synonym: "cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating)" EXACT [EC:1.2.1.44]
synonym: "cinnamoyl CoA reductase activity" EXACT []
synonym: "cinnamoyl-CoA:NADPH reductase activity" EXACT [EC:1.2.1.44]
synonym: "cinnamoyl-coenzyme A reductase activity" EXACT [EC:1.2.1.44]
synonym: "feruloyl coenzyme A reductase activity" EXACT [EC:1.2.1.44]
synonym: "feruloyl-CoA reductase activity" EXACT [EC:1.2.1.44]
synonym: "ferulyl-CoA reductase activity" EXACT [EC:1.2.1.44]
synonym: "p-hydroxycinnamoyl coenzyme A reductase activity" EXACT [EC:1.2.1.44]
xref: EC:1.2.1.44
xref: MetaCyc:CINNAMOYL-COA-REDUCTASE-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016622
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]
subset: gosubset_prok
xref: EC:1.2.2
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0016623
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
subset: gosubset_prok
xref: EC:1.2.3
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0016624
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor" EXACT []
xref: EC:1.2.4
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0016625
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.2.7
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0016626
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an acceptor other than NAD, NADP, oxygen, an iron-sulfur protein, disulphide or a cytochrome." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016903

[Term]
id: GO:0016627
name: oxidoreductase activity, acting on the CH-CH group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.3.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" NARROW []
xref: EC:1.3
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016628
name: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
subset: gosubset_prok
xref: EC:1.3.1
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016629
name: 12-oxophytodienoate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-((1R,2R)-3-oxo-2-((Z)-pent-2-enyl)cyclopentyl)octanoate + NADP+ = (15Z)-12-oxophyto-10,15-dienoate + NADPH." [EC:1.3.1.42]
synonym: "12-oxo-phytodienoate reductase activity" EXACT []
synonym: "12-oxo-phytodienoic acid reductase activity" EXACT [EC:1.3.1.42]
synonym: "8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.42]
xref: EC:1.3.1.42
xref: MetaCyc:12-OXOPHYTODIENOATE-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016630
name: protochlorophyllide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlorophyllide A + NADP+ = protochlorophyllide + NADPH + H+." [EC:1.3.1.33]
subset: gosubset_prok
synonym: "chlorophyllide-a:NADP+ 7,8-oxidoreductase activity" EXACT [EC:1.3.1.33]
synonym: "NADPH-protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33]
synonym: "NADPH-protochlorophyllide reductase activity" EXACT [EC:1.3.1.33]
synonym: "NADPH2-protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33]
synonym: "protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33]
synonym: "protochlorophyllide photooxidoreductase activity" EXACT [EC:1.3.1.33]
xref: EC:1.3.1.33
xref: MetaCyc:RXN1F-10
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016631
name: enoyl-[acyl-carrier-protein] reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+." [EC:1.3.1.9, GOC:rb]
subset: gosubset_prok
synonym: "acyl-ACP dehydrogenase activity" EXACT [EC:1.3.1.-]
synonym: "enoyl-[acyl-carrier protein] reductase activity" EXACT []
synonym: "enoyl-ACP reductase activity" EXACT []
synonym: "enoyl-acyl carrier protein reductase" EXACT []
xref: EC:1.3.1.-
xref: MetaCyc:1.3.1.10-RXN
xref: MetaCyc:1.3.1.39-RXN
xref: MetaCyc:RXN1G-2527
xref: MetaCyc:RXN1G-2544
xref: MetaCyc:RXN1G-3232
xref: MetaCyc:RXN1G-3256
xref: MetaCyc:RXN1G-3613
xref: MetaCyc:RXN1G-3641
xref: MetaCyc:RXN1G-3667
xref: MetaCyc:RXN1G-3993
xref: MetaCyc:RXN1G-4140
xref: MetaCyc:RXN1G-45
xref: Wikipedia:Enoyl-acyl_carrier_protein_reductase
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016632
name: oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]
xref: EC:1.3.2
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016633
name: galactonolactone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." [EC:1.3.2.3]
synonym: "GLDase activity" EXACT [EC:1.3.2.3]
synonym: "GLDHase activity" EXACT [EC:1.3.2.3]
synonym: "L-galactono-1,4-lactone dehydrogenase activity" EXACT []
synonym: "L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.3.2.3]
synonym: "L-galactono-gamma-lactone dehydrogenase activity" EXACT [EC:1.3.2.3]
synonym: "L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.3.2.3]
synonym: "L-galactonolactone dehydrogenase activity" EXACT [EC:1.3.2.3]
xref: EC:1.3.2.3
xref: MetaCyc:GALACTONOLACTONE-DEHYDROGENASE-RXN
is_a: GO:0016632 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor

[Term]
id: GO:0016634
name: oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
subset: gosubset_prok
xref: EC:1.3.3
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016635
name: oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound." [GOC:jl]
subset: gosubset_prok
xref: EC:1.3.5
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016636
name: oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the CH-CH group of donors, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.3.7
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0016637
name: oxidoreductase activity, acting on the CH-CH group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or related compound, a cytochrome, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016627

[Term]
id: GO:0016638
name: oxidoreductase activity, acting on the CH-NH2 group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.4.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors" NARROW []
xref: EC:1.4
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016639
name: oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]
subset: gosubset_prok
xref: EC:1.4.1
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0016640
name: oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai]
xref: EC:1.4.2
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0016641
name: oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:1.4.3
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0016642
name: oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, disulphide as acceptor" EXACT []
xref: EC:1.4.4
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0016643
name: oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.4.7
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0016644
name: oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016638

[Term]
id: GO:0016645
name: oxidoreductase activity, acting on the CH-NH group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.5.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors" NARROW []
xref: EC:1.5
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016646
name: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
subset: gosubset_prok
xref: EC:1.5.1
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0016647
name: oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
subset: gosubset_prok
xref: EC:1.5.3
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0016648
name: oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl]
synonym: "oxidoreductase activity, acting on the CH-NH group of donors, disulphide as acceptor" EXACT []
xref: EC:1.5.4
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0016649
name: oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound." [GOC:jl]
subset: gosubset_prok
xref: EC:1.5.5
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0016650
name: oxidoreductase activity, acting on the CH-NH group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or similar compound, disulfide, NAD, NADP, oxygen or a flavin." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016645

[Term]
id: GO:0016651
name: oxidoreductase activity, acting on NADH or NADPH
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.6.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "NAD(P)H dehydrogenase" NARROW []
synonym: "oxidoreductase activity, acting on NADH or NADPH, other acceptor" NARROW []
xref: EC:1.6
xref: Reactome:4134 "oxidoreductase activity, acting on NADH or NADPH"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016652
name: oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]
subset: gosubset_prok
xref: EC:1.6.1
is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH

[Term]
id: GO:0016653
name: oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein." [GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on NADH or NADPH, haem protein as acceptor" EXACT []
xref: EC:1.6.2
is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH

[Term]
id: GO:0016655
name: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:1.6.5
is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH

[Term]
id: GO:0016656
name: monodehydroascorbate reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate." [EC:1.6.5.4]
synonym: "AFR" RELATED [EC:1.6.5.4]
synonym: "AFR-reductase activity" EXACT [EC:1.6.5.4]
synonym: "ascorbate free radical reductase activity" EXACT [EC:1.6.5.4]
synonym: "ascorbate free-radical reductase activity" EXACT [EC:1.6.5.4]
synonym: "ascorbic free radical reductase activity" EXACT [EC:1.6.5.4]
synonym: "MDAsA reductase (NADPH)" EXACT [EC:1.6.5.4]
synonym: "MDHA" RELATED [EC:1.6.5.4]
synonym: "monodehydroascorbate reductase activity" EXACT []
synonym: "NADH-semidehydroascorbate oxidoreductase activity" EXACT [EC:1.6.5.4]
synonym: "NADH:AFR oxidoreductase activity" EXACT [EC:1.6.5.4]
synonym: "NADH:ascorbate radical oxidoreductase activity" EXACT [EC:1.6.5.4]
synonym: "NADH:monodehydroascorbate oxidoreductase activity" EXACT [EC:1.6.5.4]
synonym: "NADH:semidehydroascorbic acid oxidoreductase activity" EXACT [EC:1.6.5.4]
synonym: "SDA reductase activity" EXACT [EC:1.6.5.4]
synonym: "semidehydroascorbate reductase activity" EXACT [EC:1.6.5.4]
xref: EC:1.6.5.4
xref: MetaCyc:1.6.5.4-RXN
is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor

[Term]
id: GO:0016657
name: oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:ai]
subset: gosubset_prok
xref: EC:1.6.6
is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH

[Term]
id: GO:0016658
name: oxidoreductase activity, acting on NADH or NADPH, flavin as acceptor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it was a grouping term taken from EC that no longer has any functions associated with it.
is_obsolete: true
consider: GO:0008752
consider: GO:0042602

[Term]
id: GO:0016659
name: oxidoreductase activity, acting on NADH or NADPH, other acceptor
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, a heme protein, NAD, NADP, a nitrogenous group, a quinone or similar compound or oxygen." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016651

[Term]
id: GO:0016661
name: oxidoreductase activity, acting on other nitrogenous compounds as donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.7.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors" NARROW []
xref: EC:1.7
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016662
name: oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]
subset: gosubset_prok
xref: EC:1.7.2
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0016663
name: oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
subset: gosubset_prok
xref: EC:1.7.3
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0016664
name: oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.7.7
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0016665
name: oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, oxygen, NAD or NADP." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016661

[Term]
id: GO:0016667
name: oxidoreductase activity, acting on sulfur group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.8.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on sulfur group of donors, other acceptors" NARROW []
synonym: "oxidoreductase activity, acting on sulphur group of donors" EXACT []
xref: EC:1.8
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016668
name: oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
namespace: molecular_function
alt_id: GO:0016654
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor" EXACT []
synonym: "oxidoreductase activity, acting on NADH or NADPH, disulphide as acceptor" EXACT []
synonym: "oxidoreductase activity, acting on sulphur group of donors, NAD or NADP as acceptor" EXACT []
xref: EC:1.8.1
is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH
is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors

[Term]
id: GO:0016669
name: oxidoreductase activity, acting on sulfur group of donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on sulphur group of donors, cytochrome as acceptor" EXACT []
xref: EC:1.8.2
is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors

[Term]
id: GO:0016670
name: oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor" EXACT []
xref: EC:1.8.3
is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors

[Term]
id: GO:0016671
name: oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on sulphur group of donors, disulphide as acceptor" EXACT []
xref: EC:1.8.4
is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors

[Term]
id: GO:0016672
name: oxidoreductase activity, acting on sulfur group of donors, quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on sulphur group of donors, quinone or similar compound as acceptor" EXACT []
xref: EC:1.8.5
is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors

[Term]
id: GO:0016673
name: oxidoreductase activity, acting on sulfur group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on sulphur group of donors, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.8.7
is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors

[Term]
id: GO:0016674
name: oxidoreductase activity, acting on sulfur group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or a related compound, oxygen, NAD, NADP, an iron-sulfur protein, disulfide or a cytochrome." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on sulphur group of donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016667

[Term]
id: GO:0016675
name: oxidoreductase activity, acting on heme group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.9.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on haem group of donors" EXACT []
synonym: "oxidoreductase activity, acting on heme group of donors, other acceptors" NARROW []
xref: EC:1.9
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016676
name: oxidoreductase activity, acting on heme group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on haem group of donors, oxygen as acceptor" EXACT []
xref: EC:1.9.
is_a: GO:0016675 ! oxidoreductase activity, acting on heme group of donors

[Term]
id: GO:0016677
name: oxidoreductase activity, acting on heme group of donors, nitrogenous group as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:jl]
synonym: "oxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor" EXACT []
xref: EC:1.9.6
is_a: GO:0016675 ! oxidoreductase activity, acting on heme group of donors

[Term]
id: GO:0016678
name: oxidoreductase activity, acting on heme group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces an acceptor other than a nitrogenous group or oxygen." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "oxidoreductase activity, acting on haem group of donors, other acceptors" EXACT []
is_obsolete: true
consider: GO:0016675

[Term]
id: GO:0016679
name: oxidoreductase activity, acting on diphenols and related substances as donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.10.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors" NARROW []
xref: EC:1.10
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016680
name: oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
xref: EC:1.10.1
is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors

[Term]
id: GO:0016681
name: oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]
subset: gosubset_prok
xref: EC:1.10.2
is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors

[Term]
id: GO:0016682
name: oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]
subset: gosubset_prok
xref: EC:1.10.3
is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors

[Term]
id: GO:0016683
name: oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, NAD, NADP or oxygen." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016679

[Term]
id: GO:0016684
name: oxidoreductase activity, acting on peroxide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [GOC:ai]
subset: gosubset_prok
xref: EC:1.11
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016688
name: L-ascorbate peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ascorbate + H2O2 = dehydroascorbate + 2 H2O." [EC:1.11.1.11]
synonym: "ascorbate peroxidase activity" EXACT [EC:1.11.1.11]
synonym: "ascorbic acid peroxidase activity" EXACT [EC:1.11.1.11]
synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.11]
synonym: "L-ascorbic acid peroxidase activity" EXACT [EC:1.11.1.11]
synonym: "L-ascorbic acid-specific peroxidase activity" EXACT [EC:1.11.1.11]
xref: EC:1.11.1.11
xref: MetaCyc:L-ASCORBATE-PEROXIDASE-RXN
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0016689
name: manganese peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 Mn2+ + 2 H+ + H2O2 = 2 Mn3+ + 2 H2O." [EC:1.11.1.13]
synonym: "Mn(II):hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.13]
synonym: "Mn-dependent (NADH-oxidizing) peroxidase activity" EXACT [EC:1.11.1.13]
synonym: "Mn-dependent peroxidase activity" EXACT [EC:1.11.1.13]
synonym: "peroxidase-M2" RELATED [EC:1.11.1.13]
xref: EC:1.11.1.13
xref: MetaCyc:MANGANESE-PEROXIDASE-RXN
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0016690
name: diarylpropane peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol + H2O2 = veratraldehyde + 1-(3,4-dimethylphenyl)ethane-1,2-diol + 4 H2O." [EC:1.11.1.14]
synonym: "1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.14]
synonym: "diarylpropane oxygenase activity" EXACT [EC:1.11.1.14]
synonym: "diarylpropane:oxygen,hydrogen-peroxide oxidoreductase (C-C-bond-cleaving)" EXACT [EC:1.11.1.14]
synonym: "lignin peroxidase activity" EXACT [EC:1.11.1.14]
synonym: "ligninase activity" EXACT [EC:1.11.1.14]
synonym: "ligninase I activity" NARROW [EC:1.11.1.14]
synonym: "LiP activity" NARROW [EC:1.11.1.14]
xref: EC:1.11.1.14
xref: MetaCyc:DIARYLPROPANE-PEROXIDASE-RXN
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0016691
name: chloride peroxidase activity
namespace: molecular_function
alt_id: GO:0016955
alt_id: GO:0016956
alt_id: GO:0016957
alt_id: GO:0016958
def: "Catalysis of the reaction: 2 R-H + 2 chloride + H2O2 = 2 R-Cl + 2 H2O." [EC:1.11.1.10]
subset: gosubset_prok
synonym: "chloride:hydrogen-peroxide oxidoreductase" EXACT [EC:1.11.1.10]
synonym: "chloroperoxidase activity" EXACT [EC:1.11.1.10]
synonym: "cofactor-free chloroperoxidase activity" NARROW []
synonym: "flavin-haem chloroperoxidase activity" NARROW []
synonym: "flavin-heme chloroperoxidase activity" NARROW []
synonym: "haem chloroperoxidase activity" NARROW []
synonym: "heme chloroperoxidase activity" NARROW []
synonym: "vanadium chloroperoxidase activity" NARROW []
xref: EC:1.11.1.10
xref: MetaCyc:CHLORIDE-PEROXIDASE-RXN
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0016692
name: NADH peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + H2O2 = NAD+ + 2 H2O." [EC:1.11.1.1]
subset: gosubset_prok
synonym: "diphosphopyridine nucleotide peroxidase activity" EXACT [EC:1.11.1.1]
synonym: "DPNH peroxidase activity" EXACT [EC:1.11.1.1]
synonym: "NAD peroxidase activity" EXACT [EC:1.11.1.1]
synonym: "NADH-peroxidase activity" EXACT [EC:1.11.1.1]
synonym: "NADH:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.1]
synonym: "nicotinamide adenine dinucleotide peroxidase activity" EXACT [EC:1.11.1.1]
xref: EC:1.11.1.1
xref: MetaCyc:NADH-PEROXIDASE-RXN
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0016694
name: bacterial catalase-peroxidase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it represents a bifunctional gene product.
is_obsolete: true
consider: GO:0004096
consider: GO:0004601

[Term]
id: GO:0016695
name: oxidoreductase activity, acting on hydrogen as donor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor." [GOC:jl]
comment: Note that enzymes of class EC:1.12.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on hydrogen as donor, other acceptors" NARROW []
xref: EC:1.12
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016696
name: oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP." [GOC:jl]
subset: gosubset_prok
xref: EC:1.12.1
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0016697
name: oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor
namespace: molecular_function
alt_id: GO:0016698
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome." [GOC:jl]
subset: gosubset_prok
xref: EC:1.12.2
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0016699
name: oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
namespace: molecular_function
alt_id: GO:0016736
alt_id: GO:0019110
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein." [GOC:jl]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on hydrogen as donor, iron-sulphur protein as acceptor" EXACT []
xref: EC:1.12.7
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor
is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors

[Term]
id: GO:0016700
name: oxidoreductase activity, acting on hydrogen as donor, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen is the electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP or a quinone or similar compound." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016695

[Term]
id: GO:0016701
name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor." [GOC:mah]
comment: Note that enzymes of class EC:1.13.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous" NARROW []
synonym: "oxygenase" BROAD []
xref: EC:1.13
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016702
name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.13.11
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0016703
name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.13.12
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0016704
name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous
namespace: molecular_function
def: "OBSOLETE. A grouping term for oxidoreductases acting on single donors with incorporation of molecular oxygen that cannot be more accurated categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016701

[Term]
id: GO:0016705
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]
comment: Note that enzymes of class EC:1.14.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous" NARROW []
xref: EC:1.14
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016706
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.14.11
xref: Reactome:726 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors"
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016707
name: gibberellin 3-beta-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 3-beta-hydroxy-gibberellin + succinate + CO2." [EC:1.14.11.15, GOC:kad]
synonym: "(gibberellin-20),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating)" NARROW [EC:1.14.11.15]
synonym: "(gibberrellin-20),2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating)" NARROW [EC:1.14.11.15]
synonym: "gibberellin 3-beta-hydroxylase activity" EXACT [EC:1.14.11.15]
synonym: "gibberellin 3beta-dioxygenase activity" EXACT [EC:1.14.11.15]
synonym: "gibberellin 3beta-hydroxylase activity" EXACT [EC:1.14.11.15]
xref: EC:1.14.11.15
xref: MetaCyc:RXN1F-170
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0016708
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen is incorporated into one donor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.14.12
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0016709
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.14.13
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016710
name: trans-cinnamate 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O." [EC:1.14.13.11]
synonym: "CA4H activity" NARROW [EC:1.14.13.11]
synonym: "cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11]
synonym: "cinnamate 4-monooxygenase activity" EXACT [EC:1.14.13.11]
synonym: "cinnamate hydroxylase activity" EXACT [EC:1.14.13.11]
synonym: "cinnamic 4-hydroxylase activity" EXACT [EC:1.14.13.11]
synonym: "cinnamic acid 4-hydroxylase activity" EXACT [EC:1.14.13.11]
synonym: "cinnamic acid 4-monooxygenase activity" EXACT [EC:1.14.13.11]
synonym: "cinnamic acid p-hydroxylase activity" EXACT [EC:1.14.13.11]
synonym: "cytochrome P450 cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11]
synonym: "hydroxylase, cinnamate 4-" EXACT [EC:1.14.13.11]
synonym: "oxygenase, cinnamate 4-mono-" EXACT [EC:1.14.13.11]
synonym: "t-cinnamic acid hydroxylase activity" EXACT [EC:1.14.13.11]
synonym: "trans-cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11]
synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.11]
synonym: "trans-cinnamic acid 4-hydroxylase activity" EXACT [EC:1.14.13.11]
xref: EC:1.14.13.11
xref: MetaCyc:TRANS-CINNAMATE-4-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0016711
name: flavonoid 3'-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O." [EC:1.14.13.21]
synonym: "flavonoid 3'-hydroxylase activity" EXACT [EC:1.14.13.21]
synonym: "flavonoid 3-hydroxylase (erroneous)" EXACT [EC:1.14.13.21]
synonym: "flavonoid 3-monooxygenase (erroneous)" EXACT [EC:1.14.13.21]
synonym: "flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.21]
synonym: "NADPH:flavonoid-3'-hydroxylase activity" EXACT [EC:1.14.13.21]
xref: EC:1.14.13.21
xref: MetaCyc:FLAVONOID-3-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0016712
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
alt_id: GO:0008402
alt_id: GO:0050381
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
subset: gosubset_prok
synonym: "aryl hydrocarbon hydroxylase activity" NARROW [EC:1.14.14.1]
synonym: "aryl-4-monooxygenase activity" NARROW [EC:1.14.14.1]
synonym: "cytochrome p450 activity" NARROW [EC:1.14.14.1]
synonym: "cytochrome P450 CYP19" NARROW []
synonym: "flavoprotein monooxygenase activity" EXACT [EC:1.14.14.1]
synonym: "flavoprotein-linked monooxygenase activity" EXACT [EC:1.14.14.1]
synonym: "microsomal monooxygenase activity" NARROW [EC:1.14.14.1]
synonym: "microsomal P-450" RELATED [EC:1.14.14.1]
synonym: "microsomal p450 activity" NARROW [EC:1.14.14.1]
synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)" EXACT [EC:1.14.14.1]
synonym: "unspecific monooxygenase activity" RELATED []
synonym: "xenobiotic monooxygenase activity" RELATED [EC:1.14.14.1]
xref: EC:1.14.14
xref: MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN
xref: Reactome:748 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"
xref: UM-BBD_enzymeID:e0551
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016713
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulphur protein as one donor, and incorporation of one atom of oxygen" EXACT []
xref: EC:1.14.15
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016714
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.14.16
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016715
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.14.17
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016716
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.14.18
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016717
name: oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]
subset: gosubset_prok
xref: EC:1.14.19
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016718
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous
namespace: molecular_function
def: "OBSOLETE. A grouping term for oxidoreductases, acting on paired donors with incorporation or reduction of molecular oxygen, that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016705

[Term]
id: GO:0016719
name: carotene 7,8-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O." [EC:1.14.99.30]
subset: gosubset_prok
synonym: "carotene,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.30]
synonym: "zeta-carotene desaturase activity" EXACT [EC:1.14.99.30]
xref: EC:1.14.99.30
xref: MetaCyc:1.14.99.30-RXN
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016720
name: delta12-fatty acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleate + donor-H2 + O2 = crepenynate + acceptor + H2O." [EC:1.14.99.33]
synonym: "crepenynate synthase activity" NARROW [EC:1.14.99.33]
synonym: "D12-fatty acid dehydrogenase activity" EXACT []
synonym: "delta-12 fatty acid acetylenase activity" EXACT [EC:1.14.99.33]
synonym: "delta12 fatty acid acetylenase activity" EXACT [EC:1.14.99.33]
synonym: "linoleate delta-12-fatty acid acetylenase (desaturase) activity" EXACT []
synonym: "linoleate delta12-fatty acid acetylenase (desaturase)" EXACT [EC:1.14.99.33]
synonym: "linoleate, hydrogen-donor:oxygen oxidoreductase (Delta12-unsaturating)" EXACT [EC:1.14.99.33]
xref: EC:1.14.99.33
xref: MetaCyc:1.14.99.33-RXN
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0016721
name: oxidoreductase activity, acting on superoxide radicals as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor." [GOC:ai]
subset: gosubset_prok
xref: EC:1.15
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016722
name: oxidoreductase activity, oxidizing metal ions
namespace: molecular_function
def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered." [GOC:mah]
subset: gosubset_prok
xref: EC:1.16
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016723
name: oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.16.1
is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions

[Term]
id: GO:0016724
name: oxidoreductase activity, oxidizing metal ions, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor." [GOC:mah]
subset: gosubset_prok
xref: EC:1.16.3
is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions

[Term]
id: GO:0016725
name: oxidoreductase activity, acting on CH or CH2 groups
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.17.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on CH or CH2 groups, other acceptors" NARROW []
xref: EC:1.17
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016726
name: oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]
subset: gosubset_prok
xref: EC:1.17.1
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0016727
name: oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:1.17.3
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0016728
name: oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on CH or CH2 groups, disulphide as acceptor" EXACT []
xref: EC:1.17.4
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0016729
name: oxidoreductase activity, acting on CH2 groups, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD, NADP or oxygen." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016725

[Term]
id: GO:0016730
name: oxidoreductase activity, acting on iron-sulfur proteins as donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on iron-sulphur proteins as donors" EXACT []
xref: EC:1.18
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016731
name: oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
subset: gosubset_prok
xref: EC:1.18.1
is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors

[Term]
id: GO:0016732
name: oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl]
subset: gosubset_prok
xref: EC:1.18.6
is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors

[Term]
id: GO:0016733
name: iron-iron nitrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1]
comment: This term was made obsolete because it represents a cellular component.
is_obsolete: true
replaced_by: GO:0016163
replaced_by: GO:0016611

[Term]
id: GO:0016734
name: molybdenum-iron nitrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1]
comment: This term was made obsolete because it represents a cellular component.
is_obsolete: true
replaced_by: GO:0016163
replaced_by: GO:0016612

[Term]
id: GO:0016735
name: vanadium-iron nitrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1]
comment: This term was made obsolete because it represents a cellular component.
is_obsolete: true
replaced_by: GO:0016163
replaced_by: GO:0016613

[Term]
id: GO:0016737
name: oxidoreductase activity, acting on reduced flavodoxin as donor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
subset: gosubset_prok
xref: EC:1.19
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016738
name: oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl]
subset: gosubset_prok
xref: EC:1.19.6
is_a: GO:0016737 ! oxidoreductase activity, acting on reduced flavodoxin as donor

[Term]
id: GO:0016739
name: oxidoreductase activity, acting on other substrates
namespace: molecular_function
def: "OBSOLETE. A grouping term for oxidoreductase that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016491

[Term]
id: GO:0016740
name: transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: EC:2
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016741
name: transferase activity, transferring one-carbon groups
namespace: molecular_function
def: "Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: EC:2.1
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016742
name: hydroxymethyl-, formyl- and related transferase activity
namespace: molecular_function
subset: gosubset_prok
xref: EC:2.1.2
is_a: GO:0004372 ! glycine hydroxymethyltransferase activity

[Term]
id: GO:0016743
name: carboxyl- or carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl]
subset: gosubset_prok
synonym: "carboxyl- and carbamoyltransferase activity" EXACT []
xref: EC:2.1.3
is_a: GO:0016741 ! transferase activity, transferring one-carbon groups

[Term]
id: GO:0016744
name: transferase activity, transferring aldehyde or ketonic groups
namespace: molecular_function
alt_id: GO:0016745
def: "Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "transketolase or transaldolase activity" EXACT []
xref: EC:2.2
xref: EC:2.2.1
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016746
name: transferase activity, transferring acyl groups
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: EC:2.3
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016747
name: transferase activity, transferring acyl groups other than amino-acyl groups
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]
subset: gosubset_prok
synonym: "transferase activity, transferring groups other than amino-acyl groups" EXACT [EC:2.3.1]
xref: EC:2.3.1
xref: Reactome:1087 "transferase activity, transferring acyl groups other than amino-acyl groups"
is_a: GO:0016746 ! transferase activity, transferring acyl groups

[Term]
id: GO:0016748
name: succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
xref: Reactome:1089 "succinyltransferase activity"
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0016749
name: N-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0016410 ! N-acyltransferase activity
is_a: GO:0016748 ! succinyltransferase activity

[Term]
id: GO:0016750
name: O-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016748 ! succinyltransferase activity

[Term]
id: GO:0016751
name: S-succinyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0016417 ! S-acyltransferase activity
is_a: GO:0016748 ! succinyltransferase activity

[Term]
id: GO:0016752
name: sinapoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a sinapoyl group to an acceptor molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0016753
name: O-sinapoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016752 ! sinapoyltransferase activity

[Term]
id: GO:0016754
name: sinapoylglucose-malate O-sinapoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + (S)-malate = D-glucose + sinapoyl-(S)-malate." [EC:2.3.1.92]
synonym: "1-O-sinapoyl-beta-D-glucose:(S)-malate O-sinapoyltransferase activity" EXACT [EC:2.3.1.92]
synonym: "1-sinapoylglucose-L-malate sinapoyltransferase activity" EXACT [EC:2.3.1.92]
synonym: "sinapoylglucose:malate sinapoyltransferase activity" EXACT []
xref: EC:2.3.1.92
xref: MetaCyc:2.3.1.92-RXN
is_a: GO:0016753 ! O-sinapoyltransferase activity

[Term]
id: GO:0016755
name: transferase activity, transferring amino-acyl groups
namespace: molecular_function
def: "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]
subset: gosubset_prok
synonym: "aminoacyltransferase activity" EXACT []
xref: EC:2.3.2
is_a: GO:0016746 ! transferase activity, transferring acyl groups

[Term]
id: GO:0016756
name: glutathione gamma-glutamylcysteinyltransferase activity
namespace: molecular_function
alt_id: GO:0042143
def: "Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly." [EC:2.3.2.15]
synonym: "gamma-glutamylcysteine dipeptidyl transpeptidase activity" EXACT [EC:2.3.2.15]
synonym: "glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase activity" EXACT [EC:2.3.2.15]
synonym: "phytochelatin synthase activity" EXACT [EC:2.3.2.15]
xref: EC:2.3.2.15
xref: MetaCyc:2.3.2.15-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0016757
name: transferase activity, transferring glycosyl groups
namespace: molecular_function
alt_id: GO:0016932
def: "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that enzymes of class EC:2.4.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "glycosyltransferase activity" EXACT []
synonym: "transferase activity, transferring other glycosyl groups" NARROW []
synonym: "transglycosidase activity" EXACT []
synonym: "transglycosylase activity" EXACT []
xref: EC:2.4
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016758
name: transferase activity, transferring hexosyl groups
namespace: molecular_function
def: "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
subset: gosubset_prok
synonym: "hexosyltransferase activity" EXACT []
xref: EC:2.4.1
is_a: GO:0016757 ! transferase activity, transferring glycosyl groups

[Term]
id: GO:0016759
name: cellulose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12, EC:2.4.1.29]
subset: gosubset_prok
synonym: "cellulose synthetase activity" EXACT [EC:2.4.1.29]
xref: EC:2.4.1.-
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0016760
name: cellulose synthase (UDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12]
subset: gosubset_prok
synonym: "1,4-beta-D-glucan synthase activity" EXACT [EC:2.4.1.12]
synonym: "1,4-beta-glucan synthase activity" EXACT [EC:2.4.1.12]
synonym: "beta-1,4-glucan synthase activity" EXACT [EC:2.4.1.12]
synonym: "beta-1,4-glucan synthetase activity" EXACT [EC:2.4.1.12]
synonym: "beta-1,4-glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "beta-glucan synthase activity" EXACT [EC:2.4.1.12]
synonym: "glucan synthase activity" EXACT [EC:2.4.1.12]
synonym: "GS-I" RELATED [EC:2.4.1.12]
synonym: "UDP-glucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "UDP-glucose-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "UDP-glucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "UDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "UDPglucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "UDPglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "UDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "uridine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12]
synonym: "uridine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12]
xref: EC:2.4.1.12
xref: MetaCyc:CELLULOSE-SYNTHASE-UDP-FORMING-RXN
is_a: GO:0016759 ! cellulose synthase activity
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0016761
name: cellulose synthase (GDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.29]
synonym: "cellulose synthase (guanosine diphosphate-forming) activity" EXACT [EC:2.4.1.29]
synonym: "GDP-glucose-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.29]
synonym: "GDP-glucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.29]
synonym: "GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.29]
synonym: "GDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.29]
synonym: "guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.29]
synonym: "guanosine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.29]
xref: EC:2.4.1.29
xref: MetaCyc:CELLULOSE-SYNTHASE-GDP-FORMING-RXN
is_a: GO:0016759 ! cellulose synthase activity

[Term]
id: GO:0016762
name: xyloglucan:xyloglucosyl transferase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan." [EC:2.4.1.207]
synonym: "endo-xyloglucan transferase activity" EXACT [EC:2.4.1.207]
synonym: "endoxyloglucan transferase activity" EXACT []
synonym: "xyloglucan endotransglycosylase activity" EXACT [EC:2.4.1.207]
synonym: "xyloglucan:xyloglucan xyloglucanotransferase activity" EXACT [EC:2.4.1.207]
xref: EC:2.4.1.207
xref: MetaCyc:2.4.1.207-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0016763
name: transferase activity, transferring pentosyl groups
namespace: molecular_function
def: "Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]
subset: gosubset_prok
synonym: "pentosyltransferase activity" EXACT []
xref: EC:2.4.2
xref: Reactome:1245 "transferase activity, transferring pentosyl groups"
is_a: GO:0016757 ! transferase activity, transferring glycosyl groups

[Term]
id: GO:0016764
name: transferase activity, transferring other glycosyl groups
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a glycosyl group, other than hexosyl or pentosyl, from one compound (donor) to another (acceptor)." [GOC:jl]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016757

[Term]
id: GO:0016765
name: transferase activity, transferring alkyl or aryl (other than methyl) groups
namespace: molecular_function
alt_id: GO:0016766
def: "Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "transferase activity, transferring alkyl or aryl groups, other than methyl groups" EXACT []
xref: EC:2.5
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016767
name: geranylgeranyl-diphosphate geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate." [EC:2.5.1.32]
subset: gosubset_prok
synonym: "geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.32]
synonym: "phytoene synthetase activity" EXACT [EC:2.5.1.32]
synonym: "prephytoene-diphosphate synthase activity" EXACT [EC:2.5.1.32]
synonym: "PSase activity" EXACT [EC:2.5.1.32]
xref: EC:2.5.1.32
xref: MetaCyc:2.5.1.32-RXN
is_a: GO:0004337 ! geranyltranstransferase activity

[Term]
id: GO:0016768
name: spermine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine." [EC:2.5.1.22]
synonym: "S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.22]
synonym: "spermidine aminopropyltransferase activity" EXACT [EC:2.5.1.22]
synonym: "spermine synthetase activity" EXACT [EC:2.5.1.22]
xref: EC:2.5.1.22
xref: MetaCyc:SPERMINE-SYNTHASE-RXN
xref: Reactome:1269 "spermine synthase activity"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0016769
name: transferase activity, transferring nitrogenous groups
namespace: molecular_function
def: "Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that enzymes of class EC:2.6.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "transferase activity, transferring other nitrogenous groups" NARROW []
xref: EC:2.6
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016770
name: oximinotransaminase activity
namespace: molecular_function
def: "Catalysis of the reversible transfer of an oxime group to an acceptor." [GOC:ai]
xref: EC:2.6.3
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups

[Term]
id: GO:0016771
name: transferase activity, transferring other nitrogenous groups
namespace: molecular_function
def: "OBSOLETE. Catalysis of the transfer of a nitrogenous group, other than amino, amidino or oxime, from one compound (donor) to another (acceptor)." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016769

[Term]
id: GO:0016772
name: transferase activity, transferring phosphorus-containing groups
namespace: molecular_function
def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides.
subset: gosubset_prok
xref: EC:2.7
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016773
name: phosphotransferase activity, alcohol group as acceptor
namespace: molecular_function
def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]
subset: gosubset_prok
xref: EC:2.7.1
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016774
name: phosphotransferase activity, carboxyl group as acceptor
namespace: molecular_function
def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)." [GOC:jl]
subset: gosubset_prok
xref: EC:2.7.2
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016775
name: phosphotransferase activity, nitrogenous group as acceptor
namespace: molecular_function
def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor)." [GOC:jl]
subset: gosubset_prok
xref: EC:2.7.3
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016776
name: phosphotransferase activity, phosphate group as acceptor
namespace: molecular_function
def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl]
subset: gosubset_prok
xref: EC:2.7.4
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016778
name: diphosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]
subset: gosubset_prok
xref: EC:2.7.6
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016779
name: nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_yeast
subset: gosubset_prok
xref: EC:2.7.7
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016780
name: phosphotransferase activity, for other substituted phosphate groups
namespace: molecular_function
def: "Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]
subset: gosubset_prok
xref: EC:2.7.8
xref: Reactome:1452 "phosphotransferase activity, for other substituted phosphate groups"
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016781
name: phosphotransferase activity, paired acceptors
namespace: molecular_function
def: "Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]
subset: gosubset_prok
xref: EC:2.7.9
is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups

[Term]
id: GO:0016782
name: transferase activity, transferring sulfur-containing groups
namespace: molecular_function
def: "Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "transferase activity, transferring sulphur-containing groups" EXACT []
xref: EC:2.8
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016783
name: sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "sulphurtransferase activity" EXACT []
synonym: "tRNA sulfurtransferase activity" NARROW [GOC:mah]
xref: EC:2.8.1
is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups

[Term]
id: GO:0016784
name: 3-mercaptopyruvate sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate." [EC:2.8.1.2]
subset: gosubset_prok
synonym: "3-mercaptopyruvate sulphurtransferase activity" EXACT []
synonym: "3-mercaptopyruvate:cyanide sulfurtransferase activity" EXACT [EC:2.8.1.2]
synonym: "beta-mercaptopyruvate sulfurtransferase activity" EXACT [EC:2.8.1.2]
synonym: "mercaptopyruvate sulfurtransferase activity" EXACT []
xref: EC:2.8.1.2
xref: MetaCyc:MERCAPYSTRANS-RXN
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0016785
name: transferase activity, transferring selenium-containing groups
namespace: molecular_function
def: "Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: EC:2.9
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0016786
name: selenotransferase activity
namespace: molecular_function
subset: gosubset_prok
xref: EC:2.9.1
is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups

[Term]
id: GO:0016787
name: hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
xref: EC:3
xref: Reactome:450 "hydrolase activity"
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016788
name: hydrolase activity, acting on ester bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any ester bond." [GOC:jl]
subset: gosubset_prok
synonym: "esterase activity" EXACT []
xref: EC:3.1
xref: Reactome:448 "hydrolase activity, acting on ester bonds"
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016790
name: thiolester hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [http://www.onelook.com]
subset: gosubset_prok
synonym: "thiolesterase activity" EXACT []
xref: EC:3.1.2
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0016791
name: phosphatase activity
namespace: molecular_function
alt_id: GO:0016302
def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "phosphatase" RELATED []
synonym: "phosphoric monoester hydrolase activity" EXACT []
xref: EC:3.1.3
is_a: GO:0042578 ! phosphoric ester hydrolase activity

[Term]
id: GO:0016793
name: triphosphoric monoester hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group." [GOC:ai]
subset: gosubset_prok
xref: EC:3.1.5
is_a: GO:0042578 ! phosphoric ester hydrolase activity

[Term]
id: GO:0016794
name: diphosphoric monoester hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group." [GOC:ai]
subset: gosubset_prok
xref: EC:3.1.7
is_a: GO:0042578 ! phosphoric ester hydrolase activity

[Term]
id: GO:0016795
name: phosphoric triester hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a phosphoric triester." [http://cancerweb.ncl.ac.uk/]
xref: EC:3.1.8
is_a: GO:0042578 ! phosphoric ester hydrolase activity

[Term]
id: GO:0016796
name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:mah]
comment: Note that this activity can catalyze cleavage of DNA or RNA.
subset: gosubset_prok
synonym: "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5' phosphomonoesters" EXACT []
xref: EC:3.1.15
is_a: GO:0004527 ! exonuclease activity

[Term]
id: GO:0016797
name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:mah]
comment: Note that this activity can catalyze cleavage of DNA or RNA.
subset: gosubset_prok
xref: EC:3.1.16
is_a: GO:0004527 ! exonuclease activity

[Term]
id: GO:0016798
name: hydrolase activity, acting on glycosyl bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl]
subset: gosubset_prok
synonym: "glycosidase activity" EXACT []
synonym: "glycosylase" NARROW []
synonym: "N-glycosylase" NARROW []
xref: EC:3.2
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016799
name: hydrolase activity, hydrolyzing N-glycosyl compounds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl]
subset: gosubset_prok
xref: EC:3.2.2
is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds

[Term]
id: GO:0016801
name: hydrolase activity, acting on ether bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively." [GOC:ai, GOC:jl]
subset: gosubset_prok
xref: EC:3.3
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016802
name: trialkylsulfonium hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a thioether bond, -S-." [EC:3.3.1.-, GOC:ai]
subset: gosubset_prok
synonym: "thioether hydrolase activity" EXACT []
synonym: "trialkylsulphonium hydrolase activity" EXACT []
xref: EC:3.3.1.-
is_a: GO:0016801 ! hydrolase activity, acting on ether bonds

[Term]
id: GO:0016803
name: ether hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an ether bond, -O-." [EC:3.3.2.-, GOC:ai]
subset: gosubset_prok
xref: EC:3.3.2
is_a: GO:0016801 ! hydrolase activity, acting on ether bonds

[Term]
id: GO:0016804
name: prolyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of a N-terminal proline from a peptide." [EC:3.4.11.5]
comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined.
subset: gosubset_prok
synonym: "cytosol aminopeptidase V" RELATED [EC:3.4.11.5]
synonym: "Pro-X aminopeptidase activity" EXACT [EC:3.4.11.5]
synonym: "proline aminopeptidase" BROAD [EC:3.4.11.5]
synonym: "proline iminopeptidase activity" EXACT []
xref: EC:3.4.11.5
xref: MetaCyc:3.4.11.5-RXN
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0016805
name: dipeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com]
subset: gosubset_prok
xref: EC:3.4.13
xref: Reactome:2731 "dipeptidase activity"
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0016806
name: dipeptidyl-peptidase and tripeptidyl-peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of N-terminal di- or tripeptides from a polypeptide chain." [GOC:ai]
comment: This term was made obsolete because it represents two activities.
subset: gosubset_prok
xref: EC:3.4.14
is_obsolete: true

[Term]
id: GO:0016807
name: cysteine-type carboxypeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of C-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE]
xref: EC:3.4.18
xref: MetaCyc:3.4.18.1-RXN
is_a: GO:0004180 ! carboxypeptidase activity
is_a: GO:0070004 ! cysteine-type exopeptidase activity

[Term]
id: GO:0016808
name: proprotein convertase activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
xref: EC:3.4.21.-
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0016810
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]
comment: Note that enzymes of class EC:3.5.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" NARROW []
xref: EC:3.5
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016811
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai]
subset: gosubset_prok
xref: EC:3.5.1
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0016812
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai]
subset: gosubset_prok
xref: EC:3.5.2
xref: Reactome:2753 "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0016813
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: EC:3.5.3
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0016814
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: EC:3.5.4
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0016815
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN." [http://www.onelook.com/]
subset: gosubset_prok
xref: EC:3.5.5
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0016816
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in substances other than amides, amidines and nitriles." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016810

[Term]
id: GO:0016817
name: hydrolase activity, acting on acid anhydrides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl]
subset: gosubset_prok
synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" NARROW []
xref: EC:3.6
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016818
name: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl]
subset: gosubset_prok
xref: EC:3.6.1
is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides

[Term]
id: GO:0016819
name: hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-." [GOC:ai]
synonym: "hydrolase activity, acting on acid anhydrides, in sulphonyl-containing anhydrides" EXACT []
xref: EC:3.6.2
is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides

[Term]
id: GO:0016820
name: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
namespace: molecular_function
def: "Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]
subset: gosubset_prok
xref: EC:3.6.3
is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0016821
name: hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it incorporates process information.
is_obsolete: true
replaced_by: GO:0016817

[Term]
id: GO:0016822
name: hydrolase activity, acting on acid carbon-carbon bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid carbon-carbon bond." [GOC:jl]
subset: gosubset_prok
xref: EC:3.7
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016823
name: hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group." [GOC:ai]
subset: gosubset_prok
xref: EC:3.7.1
is_a: GO:0016822 ! hydrolase activity, acting on acid carbon-carbon bonds

[Term]
id: GO:0016824
name: hydrolase activity, acting on acid halide bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid halide bond." [GOC:jl]
subset: gosubset_prok
xref: EC:3.8
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016825
name: hydrolase activity, acting on acid phosphorus-nitrogen bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond." [GOC:jl]
xref: EC:3.9
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016826
name: hydrolase activity, acting on acid sulfur-nitrogen bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid sulfur-nitrogen bond." [GOC:jl]
synonym: "hydrolase activity, acting on acid sulphur-nitrogen bonds" EXACT []
xref: EC:3.10
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016827
name: hydrolase activity, acting on acid carbon-phosphorus bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid carbon-phosphorus bond." [GOC:jl]
subset: gosubset_prok
xref: EC:3.11
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016828
name: hydrolase activity, acting on acid sulfur-sulfur bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid sulfur-sulfur bond." [GOC:jl]
synonym: "hydrolase activity, acting on acid sulphur-sulphur bonds" EXACT []
xref: EC:3.12
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0016829
name: lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]
comment: Note that enzymes of class EC:4.99.-.- should also be annotated to this term.
subset: goslim_candida
subset: goslim_goa
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "other lyase activity" NARROW []
xref: EC:4
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016830
name: carbon-carbon lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
comment: Note that enzymes of class EC:4.1.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "other carbon-carbon lyase activity" NARROW []
xref: EC:4.1
xref: Reactome:1006 "carbon-carbon lyase activity"
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016831
name: carboxy-lyase activity
namespace: molecular_function
def: "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]
subset: gosubset_prok
synonym: "decarboxylase activity" EXACT []
xref: EC:4.1.1
xref: Reactome:1605 "carboxy-lyase activity"
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0016832
name: aldehyde-lyase activity
namespace: molecular_function
alt_id: GO:0016228
def: "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [http://www.mercksource.com/]
subset: gosubset_prok
synonym: "aldolase activity" BROAD []
xref: EC:4.1.2
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0016833
name: oxo-acid-lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid." [EC:4.1.3, GOC:jl]
subset: gosubset_prok
synonym: "oxo-acid lyase activity" EXACT []
synonym: "oxoacid lyase activity" EXACT []
xref: EC:4.1.3
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0016834
name: other carbon-carbon lyase activity
namespace: molecular_function
def: "OBSOLETE. A grouping term for carbon-carbon lyases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016830

[Term]
id: GO:0016835
name: carbon-oxygen lyase activity
namespace: molecular_function
def: "Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-]
comment: Note that enzymes of class EC:4.2.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "other carbon-oxygen lyase activity" NARROW []
xref: EC:4.2
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016836
name: hydro-lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1]
subset: gosubset_prok
xref: EC:4.2.1
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0016837
name: carbon-oxygen lyase activity, acting on polysaccharides
namespace: molecular_function
def: "Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide." [EC:4.2.-.-]
subset: gosubset_prok
xref: EC:4.2.2
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0016838
name: carbon-oxygen lyase activity, acting on phosphates
namespace: molecular_function
def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate." [EC:4.2.-.-]
subset: gosubset_prok
xref: EC:4.2.3
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0016839
name: other carbon-oxygen lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a carbon-oxygen bond. Enzymes with this activity are 'miscellaneous' carbon-oxygen lyases that cannot be grouped into one of the specific subclasses of the carbon-oxygen lyases." [GOC:krc]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016835

[Term]
id: GO:0016840
name: carbon-nitrogen lyase activity
namespace: molecular_function
def: "Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-]
comment: Note that enzymes of class EC:4.3.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "other carbon-nitrogen lyase activity" NARROW []
xref: EC:4.3
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016841
name: ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate." [EC:4.3.-.-, GOC:krc]
subset: gosubset_prok
xref: EC:4.3.1
is_a: GO:0016840 ! carbon-nitrogen lyase activity

[Term]
id: GO:0016842
name: amidine-lyase activity
namespace: molecular_function
def: "Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate." [EC:4.3.-.-, GOC:krc]
subset: gosubset_prok
xref: EC:4.3.2
is_a: GO:0016840 ! carbon-nitrogen lyase activity

[Term]
id: GO:0016843
name: amine-lyase activity
namespace: molecular_function
def: "Catalysis of the release of amides by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate." [EC:4.3.-.-, GOC:krc]
subset: gosubset_prok
xref: EC:4.3.3
is_a: GO:0016840 ! carbon-nitrogen lyase activity

[Term]
id: GO:0016844
name: strictosidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin." [EC:4.3.3.2]
subset: gosubset_prok
synonym: "3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.2]
synonym: "3-alpha(S)-strictosidine tryptamine-lyase activity" EXACT [EC:4.3.3.2]
synonym: "STR activity" EXACT [EC:4.3.3.2]
synonym: "strictosidine synthetase activity" EXACT [EC:4.3.3.2]
xref: EC:4.3.3.2
xref: MetaCyc:STRICTOSIDINE-SYNTHASE-RXN
is_a: GO:0016843 ! amine-lyase activity

[Term]
id: GO:0016845
name: other carbon-nitrogen lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a carbon-nitrogen bond. Enzymes with this activity are 'miscellaneous' carbon-nitrogen lyases that cannot be grouped into one of the specific subclasses of the carbon-nitrogen lyases." [GOC:krc]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016840

[Term]
id: GO:0016846
name: carbon-sulfur lyase activity
namespace: molecular_function
def: "Catalysis of the elimination of H2S or substituted H2S." [EC:4.4.-.-]
subset: gosubset_prok
synonym: "carbon-sulphur lyase activity" EXACT []
xref: EC:4.4
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016847
name: 1-aminocyclopropane-1-carboxylate synthase activity
namespace: molecular_function
alt_id: GO:0034100
def: "Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine." [EC:4.4.1.14]
comment: Note that this function was formerly EC:4.1.99.4.
subset: gosubset_prok
synonym: "1-aminocyclopropane-1-carboxylate synthetase activity" EXACT [EC:4.4.1.14]
synonym: "1-aminocyclopropane-1-carboxylic acid synthase activity" EXACT [EC:4.4.1.14]
synonym: "1-aminocyclopropanecarboxylate synthase activity" EXACT [EC:4.4.1.14]
synonym: "ACC synthase activity" EXACT [EC:4.4.1.14]
synonym: "aminocyclopropanecarboxylate synthase activity" EXACT [EC:4.4.1.14]
synonym: "aminocyclopropanecarboxylic acid synthase activity" EXACT [EC:4.4.1.14]
synonym: "L-VG deaminase activity" RELATED [PMID:11470512]
synonym: "L-vinylglycine deaminase activity" RELATED [PMID:11470512]
synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming)" EXACT [EC:4.4.1.14]
synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase activity" EXACT [EC:4.4.1.14]
xref: EC:4.4.1.14
xref: MetaCyc:4.4.1.14-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0016848
name: carbon-halide lyase activity
namespace: molecular_function
def: "Catalysis of the breakage of a bond between carbon and any halogen atom." [GOC:mah]
subset: gosubset_prok
xref: EC:4.5
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016849
name: phosphorus-oxygen lyase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]
subset: gosubset_prok
xref: EC:4.6
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016850
name: other lyase activity
namespace: molecular_function
def: "OBSOLETE. A grouping term for lyases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016829

[Term]
id: GO:0016851
name: magnesium chelatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+." [EC:6.6.1.1]
comment: Note that this was EC:4.99.1.1.
subset: gosubset_prok
synonym: "magnesium-chelatase activity" EXACT [EC:6.6.1.1]
synonym: "magnesium-protoporphyrin chelatase activity" EXACT [EC:6.6.1.1]
synonym: "magnesium-protoporphyrin IX chelatase activity" EXACT [EC:6.6.1.1]
synonym: "Mg-chelatase activity" BROAD [EC:6.6.1.1]
synonym: "Mg-protoporphyrin IX chelatase activity" EXACT [EC:6.6.1.1]
synonym: "Mg-protoporphyrin IX magnesio-lyase activity" EXACT [EC:6.6.1.1]
synonym: "Mg-protoporphyrin IX magnesium-lyase activity" EXACT [EC:6.6.1.1]
synonym: "protoporphyrin IX magnesium-chelatase activity" EXACT [EC:6.6.1.1]
synonym: "protoporphyrin IX Mg-chelatase activity" EXACT [EC:6.6.1.1]
xref: EC:6.6.1.1
xref: MetaCyc:RXN1F-20
is_a: GO:0051003 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes

[Term]
id: GO:0016852
name: sirohydrochlorin cobaltochelatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+." [EC:4.99.1.3]
subset: gosubset_prok
synonym: "anaerobic cobalt chelatase activity" EXACT []
synonym: "CbiK" NARROW []
synonym: "CbiX" RELATED [EC:4.99.1.3]
synonym: "CbiXS" RELATED [EC:4.99.1.3]
synonym: "cobalt-sirohydrochlorin cobalt-lyase (sirohydrochlorin-forming)" EXACT [EC:4.99.1.3]
synonym: "sirohydrochlorin cobalt-lyase activity" EXACT [EC:4.99.1.3]
xref: EC:4.99.1.3
xref: MetaCyc:4.99.1.3-RXN
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0016853
name: isomerase activity
namespace: molecular_function
def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that enzymes of class EC:5.99.-.- should also be annotated to this term.
subset: goslim_candida
subset: goslim_goa
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "other isomerase activity" NARROW []
xref: EC:5
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016854
name: racemase and epimerase activity
namespace: molecular_function
def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that enzymes of class EC:5.1.99.- should also be annotated to this term. Note that 'epimerase' refers to the conversion of an epimer into its diastereoisomer, and 'racemase' refers to the interconversion of the two enantiomers of a chiral compound.
subset: gosubset_prok
synonym: "racemase and epimerase activity, acting on other compounds" NARROW []
xref: EC:5.1
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0016855
name: racemase and epimerase activity, acting on amino acids and derivatives
namespace: molecular_function
def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid." [GOC:mah]
subset: gosubset_prok
xref: EC:5.1.1
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0016856
name: racemase and epimerase activity, acting on hydroxy acids and derivatives
namespace: molecular_function
def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:5.1.2
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0016857
name: racemase and epimerase activity, acting on carbohydrates and derivatives
namespace: molecular_function
def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:5.1.3
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0016858
name: racemase and epimerase activity, acting on other compounds
namespace: molecular_function
def: "OBSOLETE. Racemase and epimerase activity on compounds other than amino acids, hydroxy acids, carbohydrates or their derivatives." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016854

[Term]
id: GO:0016859
name: cis-trans isomerase activity
namespace: molecular_function
def: "Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: EC:5.2
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0016860
name: intramolecular oxidoreductase activity
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-]
comment: Note that enzymes of class EC:5.3.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "intramolecular isomerase activity" EXACT []
synonym: "intramolecular oxidoreductase activity, other intramolecular oxidoreductases" NARROW []
xref: EC:5.3
xref: Reactome:1429 "intramolecular oxidoreductase activity"
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0016861
name: intramolecular oxidoreductase activity, interconverting aldoses and ketoses
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears." [GOC:jl]
subset: gosubset_prok
synonym: "intramolecular isomerase activity, interconverting aldoses and ketoses" EXACT []
xref: EC:5.3.1
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0016862
name: intramolecular oxidoreductase activity, interconverting keto- and enol-groups
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears." [GOC:jl]
subset: gosubset_prok
synonym: "intramolecular isomerase activity, interconverting keto- and enol-groups" EXACT []
xref: EC:5.3.2
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0016863
name: intramolecular oxidoreductase activity, transposing C=C bonds
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.3, GOC:mah]
subset: gosubset_prok
synonym: "intramolecular isomerase activity, transposing C=C bonds" EXACT []
xref: EC:5.3.3
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0016864
name: intramolecular oxidoreductase activity, transposing S-S bonds
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.4, GOC:mah]
subset: gosubset_prok
synonym: "intramolecular isomerase activity, transposing S-S bonds" EXACT []
xref: EC:5.3.4
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0016865
name: intramolecular oxidoreductase activity, other intramolecular oxidoreductases
namespace: molecular_function
def: "OBSOLETE. A grouping term for intramolecular oxidoreductases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
synonym: "intramolecular isomerase activity, other intramolecular oxidoreductases" EXACT []
is_obsolete: true
consider: GO:0016860

[Term]
id: GO:0016866
name: intramolecular transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah]
comment: Note that enzymes of class EC:5.4.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "intramolecular transferase activity, transferring other groups" NARROW []
synonym: "mutase activity" EXACT []
xref: EC:5.4
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0016867
name: intramolecular transferase activity, transferring acyl groups
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group from one position to another within a single molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:5.4.1
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0016868
name: intramolecular transferase activity, phosphotransferases
namespace: molecular_function
alt_id: GO:0016777
def: "Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]
subset: gosubset_prok
synonym: "phosphomutase activity" EXACT []
synonym: "phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers" EXACT []
xref: EC:5.4.2
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0016869
name: intramolecular transferase activity, transferring amino groups
namespace: molecular_function
def: "Catalysis of the transfer of an amino group from one position to another within a single molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:5.4.3
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0016870
name: intramolecular transferase activity, transferring other groups
namespace: molecular_function
def: "OBSOLETE. A grouping term for intramolecular transferases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016866

[Term]
id: GO:0016871
name: cycloartenol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol." [EC:5.4.99.8]
subset: gosubset_prok
synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming)" EXACT [EC:5.4.99.8]
synonym: "2,3-epoxysqualene cycloartenol-cyclase activity" EXACT [EC:5.4.99.8]
synonym: "2,3-epoxysqualene--cycloartenol cyclase activity" EXACT [EC:5.4.99.8]
synonym: "2,3-oxidosqualene-cycloartenol cyclase activity" EXACT [EC:5.4.99.8]
synonym: "oxidosqualene:cycloartenol cyclase activity" EXACT [PMID:18033581]
synonym: "squalene-2,3-epoxide-cycloartenol cyclase activity" EXACT [EC:5.4.99.8]
xref: EC:5.4.99.8
xref: MetaCyc:CYCLOARTENOL-SYNTHASE-RXN
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0016872
name: intramolecular lyase activity
namespace: molecular_function
def: "The catalysis of certain rearrangements of a molecule to break or form a ring." [GOC:jl, http://www.mercksource.com/]
subset: gosubset_prok
xref: EC:5.5
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0016873
name: other isomerase activity
namespace: molecular_function
def: "OBSOLETE. A grouping term for isomerases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016853

[Term]
id: GO:0016874
name: ligase activity
namespace: molecular_function
def: "Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_goa
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: EC:6
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0016875
name: ligase activity, forming carbon-oxygen bonds
namespace: molecular_function
def: "Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl]
subset: gosubset_prok
xref: EC:6.1
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0016876
name: ligase activity, forming aminoacyl-tRNA and related compounds
namespace: molecular_function
def: "Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound." [GOC:jl]
subset: gosubset_prok
xref: EC:6.1.1
is_a: GO:0016875 ! ligase activity, forming carbon-oxygen bonds

[Term]
id: GO:0016877
name: ligase activity, forming carbon-sulfur bonds
namespace: molecular_function
def: "Catalysis of the ligation of two substances via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl]
subset: gosubset_prok
synonym: "ligase activity, forming carbon-sulphur bonds" EXACT []
xref: EC:6.2
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0016878
name: acid-thiol ligase activity
namespace: molecular_function
def: "Catalysis of the ligation of an acid and a thiol via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl]
subset: gosubset_prok
xref: EC:6.2.1
is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds

[Term]
id: GO:0016879
name: ligase activity, forming carbon-nitrogen bonds
namespace: molecular_function
def: "Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl]
comment: Note that enzymes of class EC:6.3.4.- should also be annotated to this term.
subset: gosubset_prok
synonym: "other carbon-nitrogen ligase activity" NARROW []
xref: EC:6.3
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0016880
name: acid-ammonia (or amide) ligase activity
namespace: molecular_function
def: "Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl]
subset: gosubset_prok
synonym: "amide synthase activity" EXACT []
xref: EC:6.3.1
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0016881
name: acid-amino acid ligase activity
namespace: molecular_function
def: "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl]
subset: gosubset_prok
synonym: "peptide synthase activity" EXACT []
xref: EC:6.3.2
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0016882
name: cyclo-ligase activity
namespace: molecular_function
def: "Catalysis of the ligation of two substances via a carbon-nitrogen bond to form a heterocyclic product, with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [EC:6.3.3.1, EC:6.3.3.2, EC:6.3.3.4, GOC:mah]
subset: gosubset_prok
xref: EC:6.3.3
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0016883
name: other carbon-nitrogen ligase activity
namespace: molecular_function
def: "OBSOLETE. A grouping term for carbon-nitrogen ligases that cannot be more accurately categorized." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016879

[Term]
id: GO:0016884
name: carbon-nitrogen ligase activity, with glutamine as amido-N-donor
namespace: molecular_function
alt_id: GO:0016003
def: "Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532]
subset: gosubset_prok
xref: EC:6.3.5
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0016885
name: ligase activity, forming carbon-carbon bonds
namespace: molecular_function
def: "Catalysis of the ligation of two substances via a carbon-carbon bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl]
subset: gosubset_prok
xref: EC:6.4
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0016886
name: ligase activity, forming phosphoric ester bonds
namespace: molecular_function
def: "Catalysis of the ligation of two substances via a phosphoric ester bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl]
subset: gosubset_prok
xref: EC:6.5
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0016887
name: ATPase activity
namespace: molecular_function
alt_id: GO:0004002
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "(Ca2+ + Mg2+)-ATPase" NARROW [EC:3.6.1.3]
synonym: "adenosine 5'-triphosphatase activity" EXACT [EC:3.6.1.3]
synonym: "adenosine triphosphatase activity" EXACT [EC:3.6.1.3]
synonym: "adenosinetriphosphatase activity" EXACT []
synonym: "ATP hydrolase activity" EXACT [EC:3.6.1.3]
synonym: "ATP monophosphatase activity" EXACT [EC:3.6.1.3]
synonym: "ATP phosphohydrolase activity" EXACT []
synonym: "complex V (mitochondrial electron transport)" RELATED [EC:3.6.1.3]
synonym: "HCO3--ATPase" NARROW [EC:3.6.1.3]
synonym: "SV40 T-antigen" RELATED [EC:3.6.1.3]
xref: MetaCyc:ADENOSINETRIPHOSPHATASE-RXN
xref: MetaCyc:ATP-PYROPHOSPHATASE-RXN
xref: Reactome:1401 "ATPase activity"
is_a: GO:0017111 ! nucleoside-triphosphatase activity

[Term]
id: GO:0016888
name: endodeoxyribonuclease activity, producing 5'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]
subset: gosubset_prok
synonym: "endodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT []
xref: EC:3.1.21
is_a: GO:0004520 ! endodeoxyribonuclease activity
is_a: GO:0016893 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

[Term]
id: GO:0016889
name: endodeoxyribonuclease activity, producing 3'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai]
subset: gosubset_prok
synonym: "endodeoxyribonuclease activity, producing other than 5'-phosphomonoesters" EXACT []
xref: EC:3.1.22
is_a: GO:0004520 ! endodeoxyribonuclease activity
is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters

[Term]
id: GO:0016890
name: site-specific endodeoxyribonuclease activity, specific for altered base
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks." [GOC:jl]
subset: gosubset_prok
xref: EC:3.1.25
is_a: GO:0004520 ! endodeoxyribonuclease activity

[Term]
id: GO:0016891
name: endoribonuclease activity, producing 5'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]
subset: gosubset_prok
xref: EC:3.1.26
is_a: GO:0004521 ! endoribonuclease activity
is_a: GO:0016893 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

[Term]
id: GO:0016892
name: endoribonuclease activity, producing 3'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai]
subset: gosubset_prok
synonym: "endoribonuclease activity, producing other than 5'-phosphomonoesters" EXACT []
xref: EC:3.1.27
is_a: GO:0004521 ! endoribonuclease activity
is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters

[Term]
id: GO:0016893
name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:mah]
comment: Note that this activity can catalyze cleavage of DNA or RNA.
subset: gosubset_prok
synonym: "5'-endonuclease activity" EXACT []
synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters" RELATED []
xref: EC:3.1.30
is_a: GO:0004519 ! endonuclease activity

[Term]
id: GO:0016894
name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah]
comment: Note that this activity can catalyze cleavage of DNA or RNA.
subset: gosubset_prok
synonym: "3'-endonuclease activity" EXACT []
synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters" RELATED []
xref: EC:3.1.31
is_a: GO:0004519 ! endonuclease activity

[Term]
id: GO:0016895
name: exodeoxyribonuclease activity, producing 5'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai]
subset: gosubset_prok
synonym: "exodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT []
xref: EC:3.1.11
is_a: GO:0004529 ! exodeoxyribonuclease activity
is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

[Term]
id: GO:0016896
name: exoribonuclease activity, producing 5'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai]
subset: gosubset_prok
synonym: "exoribonuclease activity, producing 5' phosphomonoesters" EXACT []
xref: EC:3.1.13
is_a: GO:0004532 ! exoribonuclease activity
is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

[Term]
id: GO:0016897
name: exoribonuclease activity, producing 3'-phosphomonoesters
namespace: molecular_function
def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:ai]
xref: EC:3.1.14
is_a: GO:0004532 ! exoribonuclease activity
is_a: GO:0016797 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters

[Term]
id: GO:0016898
name: oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:1.1.2
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016899
name: oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:1.1.3
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016900
name: oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule." [GOC:ai]
synonym: "oxidoreductase activity, acting on the CH-OH group of donors, disulphide as acceptor" EXACT []
xref: EC:1.1.4
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016901
name: oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai]
subset: gosubset_prok
xref: EC:1.1.5
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0016902
name: oxidoreductase activity, acting on the CH-OH group of donors, other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, NAD, NADP, oxygen or a quinone or similar compound." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0016614

[Term]
id: GO:0016903
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]
comment: Note that enzymes of class EC:1.2.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors" NARROW []
xref: EC:1.2
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0016905
name: myosin heavy chain kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]
synonym: "ATP:myosin heavy-chain O-phosphotransferase activity" EXACT [EC:2.7.11.7]
synonym: "ATP:myosin-heavy-chain O-phosphotransferase activity" EXACT [EC:2.7.11.7]
synonym: "calmodulin-dependent myosin heavy chain kinase activity" EXACT [EC:2.7.11.7]
synonym: "MHCK" RELATED [EC:2.7.11.7]
synonym: "MIHC kinase activity" EXACT [EC:2.7.11.7]
synonym: "myosin heavy chain kinase A activity" EXACT [EC:2.7.11.7]
synonym: "myosin heavy-chain kinase activity" EXACT [EC:2.7.11.7]
synonym: "myosin I heavy-chain kinase activity" NARROW [EC:2.7.11.7]
synonym: "myosin II heavy-chain kinase activity" NARROW [EC:2.7.11.7]
synonym: "myosin-heavy-chain kinase activity" EXACT [EC:2.7.11.7]
synonym: "STK6" RELATED [EC:2.7.11.7]
xref: EC:2.7.11.7
is_a: GO:0004683 ! calmodulin-dependent protein kinase activity

[Term]
id: GO:0016906
name: sterol 3-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol." [EC:2.4.1.173]
synonym: "sterol 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.173]
synonym: "sterol glucosyltransferase activity" EXACT []
synonym: "sterol-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173]
synonym: "sterol:UDPG glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-sterol beta-glucosyltransferase activity" EXACT [EC:2.4.1.173]
synonym: "UDP-glucose-sterol glucosyltransferase activity" EXACT [EC:2.4.1.173]
synonym: "UDP-glucose:sterol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173]
synonym: "UDP-glucose:sterol glucosyltransferase activity" EXACT []
synonym: "UDPG-SGTase activity" EXACT [EC:2.4.1.173]
synonym: "UDPG:sterol glucosyltransferase activity" EXACT []
synonym: "UDPglucose:sterol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173]
synonym: "uridine diphosphoglucose-poriferasterol glucosyltransferase activity" EXACT [EC:2.4.1.173]
synonym: "uridine diphosphoglucose-sterol glucosyltransferase activity" EXACT [EC:2.4.1.173]
xref: EC:2.4.1.173
xref: MetaCyc:STEROL-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0016907
name: G-protein coupled acetylcholine receptor activity
namespace: molecular_function
def: "Combining with acetylcholine to initiate a change in cell activity via activation of a G protein." [GOC:mah]
synonym: "G protein coupled acetylcholine receptor activity" EXACT []
synonym: "G-protein-coupled acetylcholine receptor activity" EXACT []
is_a: GO:0008227 ! G-protein coupled amine receptor activity
is_a: GO:0015464 ! acetylcholine receptor activity

[Term]
id: GO:0016908
name: MAP kinase 2 activity
namespace: molecular_function
synonym: "ERK2" EXACT []
xref: EC:2.7.11.-
xref: MetaCyc:2.7.11.24-RXN
is_a: GO:0004707 ! MAP kinase activity

[Term]
id: GO:0016909
name: SAP kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of proteins. A family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. Strongly activated by stress signals such as heat or osmotic shock, DNA-damaging agents, inhibitors of protein synthesis and pro-inflammatory cytokines." [GOC:ma]
synonym: "SAPK" EXACT []
synonym: "stress-activated kinase activity" EXACT []
synonym: "stress-activated protein kinase activity" EXACT []
xref: EC:2.7.11.-
is_a: GO:0004707 ! MAP kinase activity

[Term]
id: GO:0016910
name: SAP kinase 3 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a gene product.
synonym: "SAPK3" EXACT []
is_obsolete: true
consider: GO:0004674
consider: GO:0004871
consider: GO:0007254

[Term]
id: GO:0016911
name: SAP kinase 4 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a gene product.
synonym: "SAPK4" EXACT []
is_obsolete: true
consider: GO:0004674
consider: GO:0004871
consider: GO:0007254

[Term]
id: GO:0016912
name: SAP kinase 5 activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because there are no known gene products that would be described as 'SAP kinase 5', and the term name implies that it refers to a gene product.
synonym: "SAPK5" EXACT []
is_obsolete: true
consider: GO:0004674
consider: GO:0004871
consider: GO:0007254

[Term]
id: GO:0016913
name: follicle-stimulating hormone activity
namespace: molecular_function
def: "The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis." [ISBN:0198547684]
synonym: "follitropin activity" EXACT [ISBN:0198506732]
synonym: "FSH activity" EXACT [GOC:mah]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0016914
name: follicle-stimulating hormone complex
namespace: cellular_component
def: "A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity." [ISBN:0198547684]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0016915
name: activin
namespace: molecular_function
def: "OBSOLETE. A nonsteroidal regulator, composed of two covalently linked beta subunits, that is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0005160
consider: GO:0046881

[Term]
id: GO:0016916
name: inhibin
namespace: molecular_function
def: "OBSOLETE. Either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0005160
consider: GO:0046882

[Term]
id: GO:0016917
name: GABA receptor activity
namespace: molecular_function
def: "Combining with gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to initiate a change in cell activity." [GOC:jl, http://cancerweb.ncl.ac.uk/]
comment: See also the molecular function term 'neurotransmitter receptor activity ; GO:0030594'.
synonym: "4-aminobutanoate receptor activity" EXACT []
synonym: "4-aminobutyrate receptor activity" EXACT []
synonym: "GABA binding" EXACT []
synonym: "gamma-aminobutyrate binding" EXACT []
synonym: "gamma-aminobutyric acid binding" EXACT []
synonym: "gamma-aminobutyric acid receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0016918
name: retinal binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "blue-sensitive opsin" RELATED []
synonym: "green-sensitive opsin" RELATED []
synonym: "long-wave-sensitive opsin" RELATED []
synonym: "opsin" RELATED []
synonym: "red-sensitive opsin" RELATED []
synonym: "retinaldehyde binding" EXACT []
synonym: "short-wave-sensitive opsin" RELATED []
synonym: "UV-sensitive opsin" RELATED []
synonym: "violet-sensitive opsin" RELATED []
synonym: "vitamin A binding" BROAD []
is_a: GO:0005501 ! retinoid binding
is_a: GO:0019842 ! vitamin binding

[Term]
id: GO:0016919
name: nardilysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys." [EC:3.4.24.61]
comment: This term was made obsolete because it represents a gene product.
synonym: "N-arginine dibasic convertase activity" EXACT [EC:3.4.24.61]
synonym: "NRD convertase activity" EXACT [EC:3.4.24.61]
synonym: "NRD-convertase activity" EXACT [EC:3.4.24.61]
xref: EC:3.4.24.61
xref: MetaCyc:3.4.24.61-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0016920
name: pyroglutamyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein." [EC:3.4.19.3, EC:3.4.19.6, GOC:mah]
subset: gosubset_prok
xref: EC:3.4.19.-
is_a: GO:0008242 ! omega peptidase activity

[Term]
id: GO:0016921
name: pyroglutamyl-peptidase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides." [EC:3.4.19.6]
comment: This term was made obsolete because it represents a gene product.
synonym: "PAP-II activity" EXACT [EC:3.4.19.6]
synonym: "pyroglutamate aminopeptidase II" RELATED [EC:3.4.19.6]
synonym: "pyroglutamyl aminopeptidase II activity" EXACT [EC:3.4.19.6]
synonym: "pyroglutamyl peptidase II" RELATED [EC:3.4.19.6]
synonym: "thyroliberin-hydrolyzing pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6]
synonym: "thyroliberinase activity" NARROW [EC:3.4.19.6]
synonym: "thyrotropin-releasing factor pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6]
synonym: "thyrotropin-releasing hormone degrading ectoenzyme activity" NARROW [EC:3.4.19.6]
synonym: "thyrotropin-releasing hormone-degrading peptidase activity" EXACT [EC:3.4.19.6]
synonym: "thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6]
synonym: "TRH-DE activity" NARROW [EC:3.4.19.6]
synonym: "TRH-degrading ectoenzyme activity" NARROW [EC:3.4.19.6]
synonym: "TRH-specific aminopeptidase activity" NARROW [EC:3.4.19.6]
xref: EC:3.4.19.6
xref: MetaCyc:3.4.19.6-RXN
is_obsolete: true
replaced_by: GO:0008237
replaced_by: GO:0016920

[Term]
id: GO:0016922
name: ligand-dependent nuclear receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein." [GOC:mah, PMID:7776974]
synonym: "ligand-dependent nuclear receptor interactor activity" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0016923
name: ligand-dependent thyroid hormone receptor interactor activity
namespace: molecular_function
def: "OBSOLETE. Ligand dependent interaction with the thyroid hormone receptor." [PMID:7776974]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
synonym: "TRIP4" RELATED []
is_obsolete: true
consider: GO:0046966

[Term]
id: GO:0016925
name: protein sumoylation
namespace: biological_process
alt_id: GO:0006485
alt_id: GO:0016927
def: "The process by which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein." [GOC:jl, PMID:11265250]
synonym: "protein sumolation" EXACT []
synonym: "small ubiquitin-related protein 1 conjugation" EXACT []
synonym: "SUMO-protein conjugation" EXACT []
synonym: "sumoylation" EXACT []
xref: Wikipedia:SUMO_protein
is_a: GO:0032446 ! protein modification by small protein conjugation
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0016926
name: protein desumoylation
namespace: biological_process
alt_id: GO:0016928
def: "The process by which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:jl, PMID:11265250]
synonym: "desumoylation" EXACT []
synonym: "protein desumolation" EXACT []
is_a: GO:0043687 ! post-translational protein modification
is_a: GO:0070646 ! protein modification by small protein removal

[Term]
id: GO:0016929
name: SUMO-specific protease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of SUMO, a small ubiquitin-related modifier, from previously sumoylated substrates." [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250]
synonym: "SUSP" NARROW []
synonym: "ULP" NARROW []
is_a: GO:0019783 ! small conjugating protein-specific protease activity

[Term]
id: GO:0016931
name: vasopressin activated calcium mobilizing receptor activity
namespace: molecular_function
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0016933
name: extracellular-glycine-gated ion channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
synonym: "glycine receptor" BROAD []
is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity

[Term]
id: GO:0016934
name: extracellular-glycine-gated chloride channel activity
namespace: molecular_function
alt_id: GO:0004891
def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'receptor activity ; GO:0004872'.
synonym: "glycine receptor" BROAD []
synonym: "glycine-inhibited chloride channel activity" RELATED []
is_a: GO:0005237 ! inhibitory extracellular ligand-gated ion channel activity
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0016933 ! extracellular-glycine-gated ion channel activity

[Term]
id: GO:0016935
name: glycine-gated chloride channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts." [GOC:mah]
is_a: GO:0034707 ! chloride channel complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0016936
name: galactoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any glycoside in which the sugar moiety is galactose." [ChEBI:24163, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0016937
name: short-branched-chain-acyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a short branched chain fatty acid residue." [GOC:mah]
xref: EC:1.3.99.-
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0016938
name: kinesin I complex
namespace: cellular_component
def: "A complex of two kinesin heavy chains and two kinesin light chains." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html]
is_a: GO:0005871 ! kinesin complex

[Term]
id: GO:0016939
name: kinesin II complex
namespace: cellular_component
def: "A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html]
is_a: GO:0005871 ! kinesin complex

[Term]
id: GO:0016941
name: natriuretic peptide receptor activity
namespace: molecular_function
is_a: GO:0001653 ! peptide receptor activity

[Term]
id: GO:0016942
name: insulin-like growth factor binding protein complex
namespace: cellular_component
def: "A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development." [GOC:jl]
subset: goslim_pir
synonym: "IGF binding protein complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0016943
name: RNA polymerase I transcription elongation factor activity
namespace: molecular_function
def: "Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase I following transcription initiation." [GOC:mah]
synonym: "Pol I transcription elongation factor activity" EXACT []
is_a: GO:0003711 ! transcription elongation regulator activity

[Term]
id: GO:0016944
name: RNA polymerase II transcription elongation factor activity
namespace: molecular_function
def: "Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase II following transcription initiation." [GOC:mah]
synonym: "Pol II transcription elongation factor activity" EXACT []
is_a: GO:0003711 ! transcription elongation regulator activity

[Term]
id: GO:0016945
name: RNA polymerase III transcription elongation factor activity
namespace: molecular_function
def: "Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase III following transcription initiation." [GOC:mah]
synonym: "Pol III transcription elongation factor activity" EXACT []
is_a: GO:0003711 ! transcription elongation regulator activity

[Term]
id: GO:0016946
name: cathepsin F activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2." [EC:3.4.22.41]
comment: This term was made obsolete because it represents a gene product.
xref: EC:3.4.22.41
xref: MetaCyc:3.4.22.41-RXN
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0016959
name: class I ribonucleotide reductase activity
namespace: molecular_function
synonym: "aerobic non-heme iron-dependent ribonucleotide reductase activity" EXACT []
xref: Reactome:4419 "class I ribonucleotide reductase activity"
is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity

[Term]
id: GO:0016960
name: class II ribonucleotide reductase activity
namespace: molecular_function
synonym: "adenosylcobalamin-dependent ribonucleotide reductase activity" EXACT []
synonym: "class II ribonucleoside-diphosphate reductase activity" EXACT []
is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity

[Term]
id: GO:0016961
name: class III ribonucleotide reductase activity
namespace: molecular_function
synonym: "anaerobic iron-sulfur-dependent ribonucleotide reductase activity" EXACT []
is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity

[Term]
id: GO:0016962
name: receptor-associated protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes a gene product and not a molecular function.
is_obsolete: true
consider: GO:0005102
consider: GO:0005515

[Term]
id: GO:0016963
name: alpha-2 macroglobulin receptor-associated protein activity
namespace: molecular_function
def: "OBSOLETE. Interaction with the alpha-2 macroglobulin receptor and glycoprotein gp330 forming a complex with the alpha-2 macroglobulin receptor light and heavy chains." [GOC:curators]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
is_obsolete: true
consider: GO:0005102
consider: GO:0005515

[Term]
id: GO:0016964
name: alpha-2 macroglobulin receptor activity
namespace: molecular_function
def: "Combining with an alpha-2 macroglobulin to initiate a change in cell activity." [GOC:ma]
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0016966
name: nitric oxide reductase activity
namespace: molecular_function
alt_id: GO:0016967
alt_id: GO:0016968
def: "Catalysis of the reaction: nitrous oxide + acceptor + H2O = 2 nitric oxide + reduced acceptor." [EC:1.7.99.7, MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN]
subset: gosubset_prok
synonym: "CYP55" NARROW []
synonym: "cytochrome bc nitric oxide reductase activity" NARROW []
synonym: "nitric-oxide reductase activity" EXACT [EC:1.7.99.7]
synonym: "nitrogen oxide reductase activity" EXACT [EC:1.7.99.7]
synonym: "nitrous-oxide:(acceptor) oxidoreductase (NO-forming)" EXACT [EC:1.7.99.7]
synonym: "nitrous-oxide:acceptor oxidoreductase (NO-forming)" EXACT [EC:1.7.99.7]
synonym: "P450 nitric oxide reductase activity" NARROW []
synonym: "P450nor" NARROW []
xref: EC:1.7.99.7
xref: MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0016969
name: hemerythrin
namespace: molecular_function
def: "OBSOLETE. An oxygen carrier found in a few groups of invertebrates, e.g. sipunculid worms, certain molluscs, and crustaceans." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0005344

[Term]
id: GO:0016970
name: hemocyanin
namespace: molecular_function
def: "OBSOLETE. A blue, copper-containing oxygen carrier present in many molluscs and arthropods." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0005344

[Term]
id: GO:0016971
name: flavin-linked sulfhydryl oxidase activity
namespace: molecular_function
def: "Catalysis of the formation of disulfide bridges." [PMID:10899311]
is_a: GO:0016972 ! thiol oxidase activity

[Term]
id: GO:0016972
name: thiol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O." [EC:1.8.3.2]
synonym: "sulfhydryl oxidase activity" EXACT [EC:1.8.3.2]
synonym: "thiol:oxygen oxidoreductase activity" EXACT [EC:1.8.3.2]
xref: EC:1.8.3.2
xref: MetaCyc:THIOL-OXIDASE-RXN
xref: UM-BBD_enzymeID:e0808
is_a: GO:0016670 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0016973
name: poly(A)+ mRNA export from nucleus
namespace: biological_process
def: "The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai]
synonym: "poly(A) mRNA export from nucleus" EXACT []
synonym: "poly(A)+ mRNA export from cell nucleus" EXACT []
synonym: "poly(A)+ mRNA export out of nucleus" EXACT []
synonym: "poly(A)+ mRNA transport from nucleus to cytoplasm" EXACT []
synonym: "poly(A)+ mRNA-nucleus export" EXACT []
is_a: GO:0006406 ! mRNA export from nucleus

[Term]
id: GO:0016975
name: alpha-2 macroglobulin
namespace: molecular_function
def: "OBSOLETE. Inhibition of proteinase by a mechanism involving a bait region which contains specific sites, cleavage of which induces a conformational change that results in trapping of the proteinase; following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase; subsequently epsilon-amino groups of the proteinase react with thiolester linkages in the inhibitor to form stable amide links; the entrapped proteinase can now only act on low molecular mass substrates." [ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0004866

[Term]
id: GO:0016977
name: chitosanase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan." [EC:3.2.1.132]
subset: gosubset_prok
synonym: "chitosan N-acetylglucosaminohydrolase activity" EXACT [EC:3.2.1.132]
xref: EC:3.2.1.132
xref: MetaCyc:3.2.1.132-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0016979
name: lipoate-protein ligase activity
namespace: molecular_function
alt_id: GO:0008916
alt_id: GO:0016978
def: "Catalysis of the formation of carbon-nitrogen bonds between lipoate (5-(1,2-dithiolan-3-yl)pentanoate) and a protein." [EC:6.3.4.-]
subset: gosubset_prok
synonym: "lipoate-protein ligase A activity" NARROW []
synonym: "lipoate-protein ligase B activity" NARROW []
xref: EC:6.3.4.-
xref: MetaCyc:RXN-8654
xref: MetaCyc:RXN-8655
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0016980
name: creatinase activity
namespace: molecular_function
def: "Catalysis of the reaction: creatine + H2O = sarcosine + urea." [EC:3.5.3.3]
subset: gosubset_prok
synonym: "creatine amidinohydrolase activity" EXACT [EC:3.5.3.3]
xref: EC:3.5.3.3
xref: MetaCyc:CREATINASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0016983
name: cytokine beta-glucosidase activity
namespace: molecular_function
is_a: GO:0008422 ! beta-glucosidase activity

[Term]
id: GO:0016984
name: ribulose-bisphosphate carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate." [EC:4.1.1.39]
subset: gosubset_prok
synonym: "3-phospho-D-glycerate carboxy-lyase (dimerizing)" EXACT [EC:4.1.1.39]
synonym: "3-phospho-D-glycerate carboxy-lyase (dimerizing; D-ribulose-1,5-bisphosphate-forming)" EXACT [EC:4.1.1.39]
synonym: "carboxydismutase activity" RELATED [EC:4.1.1.39]
synonym: "D-ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "D-ribulose-1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "diphosphoribulose carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose 1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose 1,5-bisphosphate carboxylase/oxygenase activity" EXACT []
synonym: "ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose 1,5-diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose bisphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose diphosphate carboxylase activity" EXACT [EC:4.1.1.39]
synonym: "ribulose diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39]
synonym: "rubisco activity" EXACT []
synonym: "RuBisCO activity" EXACT [EC:4.1.1.39]
synonym: "RuBP carboxylase activity" EXACT [EC:4.1.1.39]
xref: EC:4.1.1.39
xref: MetaCyc:RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0016985
name: mannan endo-1,4-beta-mannosidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of 1,4-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans." [EC:3.2.1.78]
subset: gosubset_prok
synonym: "1,4-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.78]
synonym: "beta-1, 4-mannan 4-mannanohydrolase activity" EXACT [EC:3.2.1.78]
synonym: "beta-D-mannanase activity" EXACT [EC:3.2.1.78]
synonym: "beta-mannanase activity" EXACT [EC:3.2.1.78]
synonym: "beta-mannanase B" RELATED [EC:3.2.1.78]
synonym: "endo-1,4-beta-mannanase activity" EXACT [EC:3.2.1.78]
synonym: "endo-1,4-mannanase activity" EXACT [EC:3.2.1.78]
synonym: "endo-beta-1,4-mannase activity" EXACT [EC:3.2.1.78]
synonym: "endo-beta-mannanase activity" EXACT [EC:3.2.1.78]
xref: EC:3.2.1.78
xref: MetaCyc:3.2.1.78-RXN
is_a: GO:0004567 ! beta-mannosidase activity

[Term]
id: GO:0016986
name: transcription initiation factor activity
namespace: molecular_function
subset: gosubset_prok
synonym: "transcriptional initiation factor activity" EXACT []
is_a: GO:0030528 ! transcription regulator activity

[Term]
id: GO:0016987
name: sigma factor activity
namespace: molecular_function
def: "A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes." [GOC:krc]
subset: gosubset_prok
synonym: "sigma transcription factor" RELATED []
is_a: GO:0016986 ! transcription initiation factor activity

[Term]
id: GO:0016988
name: transcription initiation factor antagonist activity
namespace: molecular_function
def: "The function of binding to a transcription factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl]
subset: gosubset_prok
synonym: "transcriptional initiation factor antagonist activity" EXACT []
is_a: GO:0030528 ! transcription regulator activity

[Term]
id: GO:0016989
name: sigma factor antagonist activity
namespace: molecular_function
def: "The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl, Wikipedia:Anti-sigma_factors]
subset: gosubset_prok
synonym: "anti-sigma factor activity" EXACT []
is_a: GO:0016988 ! transcription initiation factor antagonist activity

[Term]
id: GO:0016990
name: arginine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3." [EC:3.5.3.6]
subset: gosubset_prok
synonym: "arginine dihydrolase activity" EXACT [EC:3.5.3.6]
synonym: "citrulline iminase activity" EXACT [EC:3.5.3.6]
synonym: "L-arginine deiminase activity" EXACT [EC:3.5.3.6]
synonym: "L-arginine iminohydrolase activity" EXACT [EC:3.5.3.6]
xref: EC:3.5.3.6
xref: MetaCyc:ARGININE-DEIMINASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0016992
name: lipoate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl." [EC:2.8.1.8, PMID:18307109]
subset: gosubset_prok
synonym: "LipA" RELATED [EC:2.8.1.8]
synonym: "lipoyl synthase activity" EXACT [EC:2.8.1.8]
synonym: "LS" RELATED [EC:2.8.1.8]
synonym: "protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.8]
synonym: "protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.8]
xref: EC:2.8.1.8
xref: MetaCyc:2.8.1.8-RXN
is_a: GO:0016783 ! sulfurtransferase activity
is_a: GO:0016979 ! lipoate-protein ligase activity
is_a: GO:0070283 ! radical SAM enzyme activity

[Term]
id: GO:0016993
name: precorrin-8X methylmutase activity
namespace: molecular_function
def: "Catalysis of the reaction: precorrin-8X = hydrogenobyrinate." [EC:5.4.1.2]
subset: gosubset_prok
synonym: "HBA synthase activity" EXACT [EC:5.4.1.2]
synonym: "hydrogenobyrinic acid-binding protein activity" NARROW [EC:5.4.1.2]
synonym: "precorrin isomerase activity" EXACT [EC:5.4.1.2]
synonym: "precorrin-8X 11,12-methylmutase activity" EXACT [EC:5.4.1.2]
xref: EC:5.4.1.2
xref: MetaCyc:5.4.1.2-RXN
is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups

[Term]
id: GO:0016994
name: precorrin-6A reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+." [EC:1.3.1.54]
subset: gosubset_prok
synonym: "precorrin-6B:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.54]
synonym: "precorrin-6X reductase activity" EXACT []
synonym: "precorrin-6Y:NADP(+) oxidoreductase activity" EXACT [EC:1.3.1.54]
synonym: "precorrin-6Y:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.54]
xref: EC:1.3.1.54
xref: MetaCyc:1.3.1.54-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0016995
name: cholesterol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + O2 = cholest-4-en-3-one + H2O2." [EC:1.1.3.6]
synonym: "3beta-hydroxy steroid oxidoreductase activity" EXACT [EC:1.1.3.6]
synonym: "3beta-hydroxysteroid:oxygen oxidoreductase activity" EXACT [EC:1.1.3.6]
synonym: "cholesterol- O2 oxidoreductase activity" EXACT [EC:1.1.3.6]
synonym: "cholesterol-O(2) oxidoreductase activity" EXACT [EC:1.1.3.6]
synonym: "cholesterol-O2 oxidoreductase activity" EXACT [EC:1.1.3.6]
synonym: "cholesterol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.6]
xref: EC:1.1.3.6
xref: MetaCyc:CHOLESTEROL-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0016996
name: endo-alpha-sialidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids." [EC:3.2.1.129]
synonym: "alpha-2,8-sialosylhydrolase activity" EXACT [EC:3.2.1.129]
synonym: "endo-N-acetylneuraminidase activity" EXACT [EC:3.2.1.129]
synonym: "endo-N-acylneuraminidase activity" EXACT [EC:3.2.1.129]
synonym: "endoneuraminidase activity" EXACT [EC:3.2.1.129]
synonym: "endosialidase activity" EXACT [EC:3.2.1.129]
synonym: "poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase activity" EXACT [EC:3.2.1.129]
synonym: "poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase activity" EXACT [EC:3.2.1.129]
synonym: "polysialoside (2->8)-alpha-sialosylhydrolase activity" EXACT [EC:3.2.1.129]
xref: EC:3.2.1.129
xref: MetaCyc:3.2.1.129-RXN
is_a: GO:0016997 ! alpha-sialidase activity

[Term]
id: GO:0016997
name: alpha-sialidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids." [GOC:mah]
subset: gosubset_prok
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0016998
name: cell wall macromolecule catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators]
subset: gosubset_prok
synonym: "cell wall breakdown" RELATED [GOC:mah]
synonym: "cell wall catabolism" RELATED [GOC:mah]
synonym: "cell wall degradation" RELATED [GOC:mah]
is_a: GO:0009056 ! catabolic process
is_a: GO:0044036 ! cell wall macromolecule metabolic process

[Term]
id: GO:0016999
name: antibiotic metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2]
subset: gosubset_prok
synonym: "antibiotic metabolism" EXACT []
is_a: GO:0017144 ! drug metabolic process

[Term]
id: GO:0017000
name: antibiotic biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators]
subset: gosubset_prok
synonym: "antibiotic anabolism" EXACT []
synonym: "antibiotic biosynthesis" EXACT []
synonym: "antibiotic formation" EXACT []
synonym: "antibiotic synthesis" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0017001
name: antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators]
subset: gosubset_prok
synonym: "antibiotic breakdown" EXACT []
synonym: "antibiotic catabolism" EXACT []
synonym: "antibiotic degradation" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0017002
name: activin receptor activity
namespace: molecular_function
def: "Combining with activin, one of two gonadal glycoproteins related to transforming growth factor beta, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0005024 ! transforming growth factor beta receptor activity

[Term]
id: GO:0017003
name: protein-heme linkage
namespace: biological_process
def: "The covalent linkage of heme and a protein." [GOC:ma]
subset: gosubset_prok
synonym: "protein-haem linkage" EXACT []
is_a: GO:0017006 ! protein-tetrapyrrole linkage

[Term]
id: GO:0017004
name: cytochrome complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:jl, GOC:mah]
subset: gosubset_prok
synonym: "cytochrome biogenesis" BROAD []
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0017005
name: 3'-tyrosyl-DNA phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of 3'-phosphotyrosyl moieties formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA." [PMID:10521354, PMID:16751265]
comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'.
is_a: GO:0070259 ! tyrosyl-DNA phosphodiesterase activity

[Term]
id: GO:0017006
name: protein-tetrapyrrole linkage
namespace: biological_process
def: "The covalent linking of a tetrapyrrole to a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0017007
name: protein-bilin linkage
namespace: biological_process
def: "The covalent linkage of bilin and a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0017006 ! protein-tetrapyrrole linkage

[Term]
id: GO:0017008
name: protein-phycobiliviolin linkage
namespace: biological_process
def: "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin." [RESID:AA0258]
subset: gosubset_prok
xref: RESID:AA0258
is_a: GO:0017007 ! protein-bilin linkage

[Term]
id: GO:0017009
name: protein-phycocyanobilin linkage
namespace: biological_process
def: "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin." [RESID:AA0131]
subset: gosubset_prok
xref: RESID:AA0131
is_a: GO:0017007 ! protein-bilin linkage

[Term]
id: GO:0017010
name: protein-phycourobilin linkage
namespace: biological_process
def: "The linkage of the chromophore phycourobilin to phycoerythrins." [RESID:AA0260]
subset: gosubset_prok
xref: RESID:AA0260
is_a: GO:0017007 ! protein-bilin linkage

[Term]
id: GO:0017011
name: protein-phycoerythrobilin linkage
namespace: biological_process
def: "The linkage of the chromophore phycoerythrobilin to phycoerythrins." [RESID:AA0132, RESID:AA0259]
subset: gosubset_prok
xref: RESID:AA0132
is_a: GO:0017007 ! protein-bilin linkage

[Term]
id: GO:0017012
name: protein-phytochromobilin linkage
namespace: biological_process
def: "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin." [RESID:AA0133]
subset: gosubset_prok
xref: RESID:AA0133
is_a: GO:0017007 ! protein-bilin linkage

[Term]
id: GO:0017013
name: protein amino acid flavinylation
namespace: biological_process
def: "The addition of a flavin group to a protein amino acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0017014
name: protein amino acid nitrosylation
namespace: biological_process
def: "The addition of a nitrosyl group to a protein amino acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0017015
name: regulation of transforming growth factor beta receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah]
synonym: "regulation of TGF-beta receptor signaling pathway" EXACT []
synonym: "regulation of TGFbeta receptor signaling pathway" EXACT []
synonym: "regulation of transforming growth factor beta receptor signalling pathway" EXACT []
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway

[Term]
id: GO:0017016
name: Ras GTPase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases." [GOC:mah]
synonym: "Ras interactor activity" RELATED []
is_a: GO:0031267 ! small GTPase binding

[Term]
id: GO:0017017
name: MAP kinase tyrosine/serine/threonine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814]
synonym: "dual-specificity MAP kinase phosphatase activity" EXACT []
xref: EC:3.1.3.-
is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity
is_a: GO:0033549 ! MAP kinase phosphatase activity

[Term]
id: GO:0017018
name: myosin phosphatase activity
namespace: molecular_function
alt_id: GO:0017019
def: "Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16]
synonym: "myosin phosphatase myosin binding" RELATED []
synonym: "myosin phosphatase, intrinsic catalyst activity" EXACT []
xref: MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN
xref: Reactome:25096 "myosin phosphatase activity"
is_a: GO:0004722 ! protein serine/threonine phosphatase activity

[Term]
id: GO:0017020
name: myosin phosphatase regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme myosin phosphatase." [EC:3.1.3.16, GOC:ai]
synonym: "myosin phosphatase, intrinsic regulator activity" NARROW []
is_a: GO:0019888 ! protein phosphatase regulator activity

[Term]
id: GO:0017021
name: myosin phosphatase myosin binding
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it describes the binding of myosin phosphatase to myosin, which is not a molecular function.
is_obsolete: true
consider: GO:0017018
consider: GO:0017022

[Term]
id: GO:0017022
name: myosin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
synonym: "myosin phosphatase myosin binding" NARROW []
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0017023
name: myosin phosphatase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin." [EC:3.1.3.16]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex

[Term]
id: GO:0017024
name: myosin I binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments." [GOC:bf, GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0017025
name: TATA-binding protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with TATA-binding protein (TBP), a component of various transcription factors." [GOC:jl, http://www.mblab.gla.ac.uk/]
synonym: "TBP binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0017026
name: procollagen C-endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III." [EC:3.4.24.19]
comment: This term was made obsolete because it represents a gene product.
synonym: "BMP1" NARROW []
synonym: "carboxyprocollagen peptidase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen C-proteinase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen C-terminal peptidase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen C-terminal proteinase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen carboxy-terminal proteinase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen carboxypeptidase activity" EXACT [EC:3.4.24.19]
synonym: "procollagen peptidase activity" EXACT [EC:3.4.24.19]
xref: EC:3.4.24.19
xref: MetaCyc:3.4.24.19-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0017027
name: transmembrane receptor protein serine/threonine kinase receptor-associated protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
is_obsolete: true
consider: GO:0005102
consider: GO:0005515

[Term]
id: GO:0017028
name: protein stabilization activity
namespace: molecular_function
def: "OBSOLETE. Strengthening of a bond between proteins. Proteins are large molecules composed of one or more chains of amino acids. The amino acids are joined in a specific order by peptide bonds." [GOC:jic, http://biotech.icmb.utexas.edu]
comment: This term was made obsolete because it represents a biological process.
is_obsolete: true
replaced_by: GO:0050821

[Term]
id: GO:0017029
name: lysosomal protein stabilization
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it contains both component and function information.
is_obsolete: true
consider: GO:0005764
consider: GO:0050821

[Term]
id: GO:0017030
name: beta-galactosidase stabilization activity
namespace: molecular_function
def: "OBSOLETE. Stabilization of the structure of beta-galactosidase." [GOC:ai]
comment: This term was made obsolete because it represents a biological process.
is_obsolete: true
replaced_by: GO:0050821

[Term]
id: GO:0017032
name: potassium:amino acid symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in)." [GOC:ai]
synonym: "potassium:amino acid transporter activity" BROAD []
is_a: GO:0005416 ! cation:amino acid symporter activity

[Term]
id: GO:0017033
name: DNA topoisomerase I binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme DNA topoisomerase I." [GOC:ai]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0017034
name: Rap guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity

[Term]
id: GO:0017038
name: protein import
namespace: biological_process
def: "The directed movement of proteins into a cell or organelle." [GOC:ai]
subset: gosubset_prok
synonym: "protein uptake" EXACT []
is_a: GO:0015031 ! protein transport

[Term]
id: GO:0017039
name: dipeptidyl-peptidase III activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides." [EC:3.4.14.4]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "dipeptidyl aminopeptidase III activity" EXACT [EC:3.4.14.4]
synonym: "dipeptidyl arylamidase III activity" EXACT [EC:3.4.14.4]
synonym: "DPP III activity" EXACT [EC:3.4.14.4]
synonym: "enkephalinase B activity" NARROW [EC:3.4.14.4]
synonym: "red cell angiotensinase activity" NARROW [EC:3.4.14.4]
xref: EC:3.4.14.4
xref: MetaCyc:3.4.14.4-RXN
is_obsolete: true
replaced_by: GO:0008239

[Term]
id: GO:0017040
name: ceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [EC:3.5.1.23]
subset: gosubset_prok
synonym: "acylsphingosine deacylase activity" EXACT [EC:3.5.1.23]
synonym: "glycosphingolipid ceramide deacylase" BROAD [EC:3.5.1.23]
synonym: "N-acylsphingosine amidohydrolase activity" EXACT [EC:3.5.1.23]
xref: EC:3.5.1.23
xref: MetaCyc:CERAMIDASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0017041
name: galactosylgalactosylglucosylceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose." [EC:3.2.1.47]
synonym: "ceramide trihexosidase activity" EXACT [EC:3.2.1.47]
synonym: "ceramidetrihexosidase activity" EXACT [EC:3.2.1.47]
synonym: "ceramidetrihexoside alpha-galactosidase activity" EXACT [EC:3.2.1.47]
synonym: "D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase activity" EXACT [EC:3.2.1.47]
synonym: "trihexosyl ceramide galactosidase activity" EXACT [EC:3.2.1.47]
synonym: "trihexosylceramide alpha-galactosidase activity" EXACT [EC:3.2.1.47]
xref: EC:3.2.1.47
xref: MetaCyc:3.2.1.47-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
is_a: GO:0017040 ! ceramidase activity

[Term]
id: GO:0017042
name: glycosylceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine." [EC:3.2.1.62]
synonym: "cerebrosidase activity" EXACT [EC:3.2.1.62]
synonym: "glycosyl ceramide glycosylhydrolase activity" EXACT [EC:3.2.1.62]
synonym: "glycosyl-N-acylsphingosine glycohydrolase activity" EXACT [EC:3.2.1.62]
synonym: "lactase-phlorizin hydrolase" BROAD [EC:3.2.1.62]
synonym: "phloretin-glucosidase activity" EXACT [EC:3.2.1.62]
synonym: "phloridzin beta-glucosidase activity" EXACT [EC:3.2.1.62]
synonym: "phloridzin glucosidase activity" EXACT [EC:3.2.1.62]
synonym: "phlorizin hydrolase activity" EXACT [EC:3.2.1.62]
xref: EC:3.2.1.62
xref: MetaCyc:GLYCOSYLCERAMIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
is_a: GO:0017040 ! ceramidase activity

[Term]
id: GO:0017043
name: adrenocorticotropin
namespace: molecular_function
def: "OBSOLETE. A polypeptide hormone which stimulates the adrenal cortex to synthesize and secrete glucocorticoid hormones." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a gene product.
synonym: "corticotropin" BROAD []
is_obsolete: true
consider: GO:0005102
consider: GO:0046886
consider: GO:0046887

[Term]
id: GO:0017044
name: melanocyte stimulating hormone activity
namespace: molecular_function
def: "The action characteristic of melanocyte stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "alpha-melanocyte stimulating hormone activity" NARROW [ISBN:0198506732]
synonym: "alpha-melanophore stimulating hormone activity" NARROW [ISBN:0198506732]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0017045
name: adrenocorticotropin-releasing hormone activity
namespace: molecular_function
def: "The action characteristic of adrenocorticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of adrenocorticotropin secretion by the anterior pituitary." [ISBN:0198506732]
synonym: "corticotropin-releasing hormone" EXACT []
xref: Wikipedia:Corticotropin-releasing_hormone
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0017046
name: peptide hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any peptide with hormonal activity in animals." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "polypeptide hormone binding" EXACT []
is_a: GO:0042277 ! peptide binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0017047
name: adrenocorticotropin-releasing hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with adrenocorticotropin-releasing hormone." [GOC:jl]
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0017048
name: Rho GTPase binding
namespace: molecular_function
alt_id: GO:0017031
def: "Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [ISBN:0198547684, PMID:12581856]
synonym: "Rho interactor activity" RELATED []
synonym: "Rhophilin" NARROW []
is_a: GO:0017016 ! Ras GTPase binding

[Term]
id: GO:0017049
name: GTP-Rho binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the GTP-bound form of the Rho protein." [GOC:mah]
is_a: GO:0017048 ! Rho GTPase binding

[Term]
id: GO:0017050
name: D-erythro-sphingosine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP." [MetaCyc:RXN3DJ-11417]
synonym: "sphingosine kinase activity" EXACT []
xref: MetaCyc:RXN3DJ-11417
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0017051
name: retinol dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol." [PMID:9857081]
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0017052
name: insulin-like growth factor binding protein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
consider: GO:0016942

[Term]
id: GO:0017053
name: transcriptional repressor complex
namespace: cellular_component
def: "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0017054
name: negative cofactor 2 complex
namespace: cellular_component
def: "A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini." [PMID:15574413]
is_a: GO:0017053 ! transcriptional repressor complex

[Term]
id: GO:0017055
name: negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators]
synonym: "down regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "down-regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "downregulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "inhibition of RNA polymerase II transcriptional preinitiation complex assembly" NARROW []
synonym: "negative regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT []
synonym: "negative regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT []
synonym: "negative regulation of RNA polymerase II transcriptional preinitiation complex formation" EXACT []
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0045898 ! regulation of RNA polymerase II transcriptional preinitiation complex assembly
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly

[Term]
id: GO:0017056
name: structural constituent of nuclear pore
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the nuclear pore complex." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0017057
name: 6-phosphogluconolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate." [EC:3.1.1.31]
subset: gosubset_prok
synonym: "6-PGL" RELATED [EC:3.1.1.31]
synonym: "6-phospho-D-glucono-1,5-lactone lactonohydrolase activity" EXACT [EC:3.1.1.31]
synonym: "phosphogluconolactonase activity" EXACT [EC:3.1.1.31]
xref: EC:3.1.1.31
xref: MetaCyc:6PGLUCONOLACT-RXN
xref: Reactome:25159 "6-phosphogluconolactonase activity"
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0017058
name: FH1 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain." [GOC:go_curators]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0017059
name: serine C-palmitoyltransferase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine." [EC:2.3.1.50]
is_a: GO:0031211 ! palmitoyltransferase complex

[Term]
id: GO:0017060
name: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.65]
synonym: "(Le(a))-dependent (alpha-3/4)-fucosyltransferase activity" NARROW [EC:2.4.1.65]
synonym: "(Lea)-dependent (alpha-3/4)-fucosyltransferase activity" EXACT [EC:2.4.1.65]
synonym: "3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65]
synonym: "alpha(1,3/1,4) fucosyltransferase III" RELATED [EC:2.4.1.65]
synonym: "alpha(1,4)-L-fucosyltransferase activity" EXACT []
synonym: "alpha-(1,3/1,4) fucosyltransferase III activity" EXACT [EC:2.4.1.65]
synonym: "alpha-(1->4)-L-fucosyltransferase activity" EXACT [EC:2.4.1.65]
synonym: "alpha-4-L-fucosyltransferase activity" EXACT [EC:2.4.1.65]
synonym: "beta-acetylglucosaminylsaccharide fucosyltransferase activity" EXACT [EC:2.4.1.65]
synonym: "blood group Lewis alpha-4-fucosyltransferase" NARROW [EC:2.4.1.65]
synonym: "blood group Lewis alpha-4-fucosyltransferase activity" NARROW [EC:2.4.1.65]
synonym: "blood-group substance Le(a)-dependent fucosyltransferase activity" NARROW [EC:2.4.1.65]
synonym: "blood-group substance Lea-dependent fucosyltransferase" NARROW [EC:2.4.1.65]
synonym: "FucT-II activity" EXACT [EC:2.4.1.65]
synonym: "galactoside 3(4)-L-fucosyltransferase activity" EXACT []
synonym: "GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65]
synonym: "GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65]
synonym: "guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65]
synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase activity" EXACT [EC:2.4.1.65]
synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65]
synonym: "Lewis alpha-(1->3/4)-fucosyltransferase" NARROW [EC:2.4.1.65]
synonym: "Lewis alpha-(1->3/4)-fucosyltransferase activity" NARROW [EC:2.4.1.65]
synonym: "Lewis blood group alpha-(1->3/4)-fucosyltransferase" NARROW [EC:2.4.1.65]
synonym: "Lewis blood group alpha-(1->3/4)-fucosyltransferase activity" NARROW [EC:2.4.1.65]
synonym: "Lewis FT activity" NARROW [EC:2.4.1.65]
synonym: "Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase" NARROW [EC:2.4.1.65]
synonym: "Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase activity" NARROW [EC:2.4.1.65]
xref: EC:2.4.1.65
xref: MetaCyc:2.4.1.65-RXN
is_a: GO:0008417 ! fucosyltransferase activity

[Term]
id: GO:0017061
name: S-methyl-5-thioadenosine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [EC:2.4.2.28]
subset: gosubset_prok
synonym: "5'-deoxy-5'-methylthioadenosine phosphorylase activity" EXACT [EC:2.4.2.28]
synonym: "5'-methylthioadenosine phosphorylase activity" EXACT []
synonym: "5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase activity" EXACT [EC:2.4.2.28]
synonym: "MeSAdo phosphorylase activity" EXACT [EC:2.4.2.28]
synonym: "MeSAdo/Ado phosphorylase activity" EXACT [EC:2.4.2.28]
synonym: "methylthioadenosine nucleoside phosphorylase activity" EXACT [EC:2.4.2.28]
synonym: "methylthioadenosine phosphorylase activity" EXACT [EC:2.4.2.28]
synonym: "MTA phosphorylase activity" EXACT [EC:2.4.2.28]
synonym: "MTAPase activity" EXACT [EC:2.4.2.28]
synonym: "S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.28]
xref: EC:2.4.2.28
xref: MetaCyc:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0017062
name: respiratory chain complex III assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex, a transmembrane lipoprotein complex that it catalyzes the reduction of cytochrome c by accepting reducing equivalents from Coenzyme Q, by the aggregation, arrangement and bonding together of its constituents." [GOC:jl, http://www.brainyencyclopedia.com/]
subset: gosubset_prok
synonym: "coenzyme Q and cytochrome c reductase complex assembly" EXACT []
synonym: "coenzyme Q and cytochrome c reductase complex biogenesis" EXACT []
synonym: "complex III assembly" EXACT []
synonym: "complex III biogenesis" EXACT []
synonym: "cytochrome bc(1) complex assembly" EXACT [GOC:mcc]
synonym: "cytochrome bc(1) complex biogenesis" EXACT []
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0017063
name: phosphatidylserine-specific phospholipase A1 activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.32]
is_a: GO:0008970 ! phospholipase A1 activity

[Term]
id: GO:0017064
name: fatty acid amide hydrolase activity
namespace: molecular_function
alt_id: GO:0017073
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0017065
name: single-strand selective uracil DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA." [GOC:elh, PMID:9224623]
synonym: "single-strand selective monofunctional uracil-DNA glycosylase activity" EXACT []
xref: EC:3.2.2.-
xref: Reactome:25182 "single-strand selective uracil DNA N-glycosylase activity"
is_a: GO:0004844 ! uracil DNA N-glycosylase activity

[Term]
id: GO:0017067
name: tyrosine-ester sulfotransferase activity
namespace: molecular_function
alt_id: GO:0008128
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + L-tyrosine methyl ester = adenosine 3',5'-bisphosphate + L-tyrosine methyl ester 4-sulfate." [EC:2.8.2.9]
synonym: "3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase activity" EXACT [EC:2.8.2.9]
synonym: "aryl sulfotransferase IV" RELATED [EC:2.8.2.9]
synonym: "L-tyrosine methyl ester sulfotransferase activity" EXACT [EC:2.8.2.9]
synonym: "tyrosine-ester sulphotransferase activity" EXACT []
xref: EC:2.8.2.9
xref: MetaCyc:TYROSINE-ESTER-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0017069
name: snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a small nuclear RNA (snRNA)." [GOC:mah]
synonym: "small nuclear RNA binding" EXACT []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0017070
name: U6 snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA)." [GOC:mah]
comment: Note that this term may be useful for annotating small nuclear RNAs (snRNAs).
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0017071
name: intracellular cyclic nucleotide activated cation channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah]
is_a: GO:0034703 ! cation channel complex

[Term]
id: GO:0017072
name: tubulin-specific chaperone activity
namespace: molecular_function
def: "OBSOLETE. Assists in the correct, non-covalent assembly of tubulin-containing structures in vivo, but is not a component of the assembled structures when performing its normal biological function." [GOC:jl, PMID:11847227]
comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function.
is_obsolete: true
consider: GO:0006461
consider: GO:0007021
consider: GO:0044183
consider: GO:0051082

[Term]
id: GO:0017074
name: procollagen N-endopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln." [EC:3.4.24.14]
comment: This term was made obsolete because it represents a gene product.
synonym: "aminoprocollagen peptidase activity" EXACT [EC:3.4.24.14]
synonym: "aminoterminal procollagen peptidase activity" EXACT [EC:3.4.24.14]
synonym: "procollagen aminopeptidase activity" EXACT [EC:3.4.24.14]
synonym: "procollagen aminoterminal protease activity" EXACT [EC:3.4.24.14]
synonym: "procollagen N-proteinase activity" EXACT [EC:3.4.24.14]
synonym: "procollagen N-terminal peptidase activity" EXACT [EC:3.4.24.14]
synonym: "procollagen N-terminal proteinase activity" EXACT [EC:3.4.24.14]
synonym: "type I/II procollagen N-proteinase activity" EXACT [EC:3.4.24.14]
synonym: "type III procollagen" RELATED [EC:3.4.24.14]
xref: EC:3.4.24.14
xref: MetaCyc:3.4.24.14-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0017075
name: syntaxin-1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-1." [GOC:ai]
is_a: GO:0019905 ! syntaxin binding

[Term]
id: GO:0017076
name: purine nucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0017077
name: oxidative phosphorylation uncoupler activity
namespace: molecular_function
alt_id: GO:0015302
def: "Catalysis of the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis." [PMID:15738989, PMID:16179945]
synonym: "mitochondrial uncoupling protein activity" NARROW []
synonym: "uncoupling protein activity" NARROW []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0017078
name: Hsc70 protein regulator activity
namespace: molecular_function
def: "OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsc70." [GOC:jl, PMID:11121403]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70 protein activity'.
synonym: "Hsc70 interacting protein" BROAD []
is_obsolete: true
replaced_by: GO:0031072
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0017080
name: sodium channel regulator activity
namespace: molecular_function
def: "Modulates the activity of a sodium channel." [GOC:mah]
is_a: GO:0016247 ! channel regulator activity

[Term]
id: GO:0017081
name: chloride channel regulator activity
namespace: molecular_function
def: "Modulates the activity of a chloride channel." [GOC:mah]
xref: Reactome:14588 "chloride channel regulator activity"
is_a: GO:0016247 ! channel regulator activity

[Term]
id: GO:0017082
name: mineralocorticoid receptor activity
namespace: molecular_function
def: "Combining with mineralocorticoid to initiate a change in cell activity." [GOC:ai]
comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'.
is_a: GO:0003707 ! steroid hormone receptor activity

[Term]
id: GO:0017083
name: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.152]
synonym: "galactoside 3-fucosyltransferase activity" EXACT [EC:2.4.1.152]
synonym: "galactoside 3-L-fucosyltransferase activity" EXACT []
synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.152]
synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" EXACT [EC:2.4.1.152]
synonym: "GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" EXACT [EC:2.4.1.152]
synonym: "guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase activity" EXACT [EC:2.4.1.152]
synonym: "guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.152]
synonym: "lewis-negative alpha-3-fucosyltransferase activity" EXACT [EC:2.4.1.152]
synonym: "Lewis-negative alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152]
synonym: "plasma alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152]
xref: EC:2.4.1.152
xref: MetaCyc:GALACTOSIDE-3-FUCOSYLTRANSFERASE-RXN
is_a: GO:0046920 ! alpha(1,3)-fucosyltransferase activity

[Term]
id: GO:0017084
name: delta1-pyrroline-5-carboxylate synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate." [MetaCyc:PROLINE-MULTI]
synonym: "D1-pyrroline-5-carboxylate synthetase activity" EXACT []
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0017085
name: response to insecticide
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "insecticide resistance" RELATED []
synonym: "insecticide susceptibility/resistance" RELATED []
is_a: GO:0009636 ! response to toxin

[Term]
id: GO:0017086
name: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex
namespace: cellular_component
alt_id: GO:0031212
def: "A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamin diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate." [EC:1.2.4.4]
synonym: "BCADH" EXACT []
synonym: "branched-chain alpha-ketoacid dehydrogenase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0017087
name: mitochondrial processing peptidase complex
namespace: cellular_component
def: "A protein complex that consists of a catalytic alpha subunit (alpha-MPP) and a regulatory beta subunit (beta-MPP), and catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion." [BRENDA:3.4.24.64, EC:3.4.24.64, GOC:mah]
comment: Note that monomeric mitochondrial processing peptidases have been observed.
is_a: GO:0043234 ! protein complex
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0017088
name: X-Pro dipeptidyl-peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile." [EC:3.4.14.11]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "PepX" RELATED [EC:3.4.14.11]
synonym: "X-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.11]
synonym: "X-prolyl dipeptidyl peptidase activity" EXACT [EC:3.4.14.11]
synonym: "Xaa-Pro dipeptidyl-peptidase activity" EXACT []
xref: EC:3.4.14.11
xref: MetaCyc:3.4.14.11-RXN
is_obsolete: true
replaced_by: GO:0008239

[Term]
id: GO:0017089
name: glycolipid transporter activity
namespace: molecular_function
def: "Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells." [GOC:ai]
is_a: GO:0005319 ! lipid transporter activity

[Term]
id: GO:0017090
name: meprin A complex
namespace: cellular_component
def: "A protein complex that is located in the cell membrane, and is involved in the metabolism of peptides, including neuropeptides. The complex has metalloendopeptidase activity that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18, GOC:mah, MEROPS_fam:M12]
synonym: "PABA peptide hydrolase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0016021 ! integral to membrane

[Term]
id: GO:0017091
name: AU-rich element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with AU-rich elements within the 3' untranslated region of mRNAs." [GOC:mah, PMID:7892223]
synonym: "ARE binding" EXACT []
synonym: "AU-specific RNA binding" EXACT []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0017092
name: sterol regulatory element-binding protein site 2 protease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus." [GOC:bf, PMID:12923525]
comment: This term was made obsolete because it represents a gene product.
synonym: "SREBP site 2 protease activity" EXACT []
is_obsolete: true
replaced_by: GO:0008237

[Term]
id: GO:0017093
name: sterol regulatory element-binding protein protease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525]
comment: This term was made obsolete because it represents a gene product.
synonym: "SREBP protease activity" EXACT []
is_obsolete: true
replaced_by: GO:0070011

[Term]
id: GO:0017094
name: sterol regulatory element-binding protein site 1 protease activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves." [GOC:bf, PMID:12923525]
comment: This term was made obsolete because it represents a gene product.
synonym: "SREBP site 1 protease activity" EXACT []
is_obsolete: true
replaced_by: GO:0008236

[Term]
id: GO:0017095
name: heparan sulfate 6-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate." [PMID:8631808]
synonym: "heparan sulphate 6-O-sulphotransferase activity" EXACT []
synonym: "heparin 6-O-sulfotransferase activity" RELATED []
xref: EC:2.8.2.-
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0017096
name: acetylserotonin O-methyltransferase activity
namespace: molecular_function
alt_id: GO:0017097
def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin (N-acetyl-5-methoxytryptamine)." [EC:2.1.1.4]
subset: gosubset_prok
synonym: "acetylserotonin methyltransferase activity" EXACT [EC:2.1.1.4]
synonym: "acetylserotonin N-methyltransferase activity" RELATED [KEGG_ENZYME:2.1.1.4]
synonym: "hydroxyindole methyltransferase activity" EXACT [EC:2.1.1.4]
synonym: "hydroxyindole O-methyltransferase activity" EXACT [EC:2.1.1.4]
synonym: "N-acetylserotonin O-methyltransferase activity" EXACT [EC:2.1.1.4]
synonym: "S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase activity" EXACT [EC:2.1.1.4]
xref: EC:2.1.1.4
xref: MetaCyc:ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0017098
name: sulfonylurea receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel." [GOC:ceb, PMID:11938023]
synonym: "sulfonylurea receptor ligand" NARROW []
synonym: "sulphonylurea receptor binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0017099
name: very-long-chain-acyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very-long-chain fatty acid residue." [GOC:mah]
xref: EC:1.3.99.-
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0017100
name: aminoacyl-tRNA synthetase auxiliary protein activity
namespace: molecular_function
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0017101
name: aminoacyl-tRNA synthetase multienzyme complex
namespace: cellular_component
def: "A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]
synonym: "aminoacyl-tRNA synthetase complex" EXACT []
synonym: "multisynthetase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0017102
name: methionyl glutamyl tRNA synthetase complex
namespace: cellular_component
def: "A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers." [GOC:mcc, PMID:11069915]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0017103
name: UTP:galactose-1-phosphate uridylyltransferase activity
namespace: molecular_function
alt_id: GO:0003982
def: "Catalysis of the reaction: UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-galactose." [EC:2.7.7.10]
synonym: "alpha-D-galactose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10]
synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.10]
synonym: "galactose 1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.10]
synonym: "galactose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10]
synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.10]
synonym: "UDPgalactose pyrophosphorylase activity" EXACT [EC:2.7.7.10]
synonym: "uridine diphosphate galactose pyrophosphorylase activity" EXACT [EC:2.7.7.10]
synonym: "uridine diphosphogalactose pyrophosphorylase activity" EXACT [EC:2.7.7.10]
synonym: "UTP-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10]
synonym: "UTP:alpha-D-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10]
synonym: "UTP:hexose-1-phosphate uridylyltransferase activity" BROAD []
xref: EC:2.7.7.10
xref: MetaCyc:UTPHEXPURIDYLYLTRANS-RXN
is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity

[Term]
id: GO:0017105
name: acyl-CoA delta11-desaturase activity
namespace: molecular_function
synonym: "acyl-CoA D11-desaturase activity" EXACT []
synonym: "acyl-CoA delta(11)-desaturase activity" EXACT []
is_a: GO:0016215 ! CoA desaturase activity

[Term]
id: GO:0017106
name: activin inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Acts to negatively regulate the activity of activin, a nonsteroidal regulator synthesized in the pituitary gland and gonads that stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
comment: This term was made obsolete because it refers to an obsolete molecular function term, 'activin'.
is_obsolete: true
consider: GO:0004871

[Term]
id: GO:0017107
name: anion exchanger adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together an anion exchanger and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07]
is_a: GO:0005515 ! protein binding
is_a: GO:0060090 ! molecular adaptor activity

[Term]
id: GO:0017108
name: 5'-flap endonuclease activity
namespace: molecular_function
def: "Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254]
synonym: "5' flap endonuclease activity" EXACT []
xref: Reactome:25632 "5'-flap endonuclease activity"
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters
is_a: GO:0048256 ! flap endonuclease activity

[Term]
id: GO:0017109
name: glutamate-cysteine ligase complex
namespace: cellular_component
def: "An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine." [EC:6.3.2.2]
synonym: "gamma-glutamylcysteine synthetase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0017110
name: nucleoside-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate." [EC:3.6.1.6]
synonym: "apyrase activity" BROAD []
synonym: "CDPase" NARROW [EC:3.6.1.6]
synonym: "IDPase" NARROW [EC:3.6.1.6]
synonym: "inosine 5'-diphosphatase" NARROW [EC:3.6.1.6]
synonym: "inosine diphosphatase" NARROW [EC:3.6.1.6]
synonym: "NDPase activity" EXACT [EC:3.6.1.6]
synonym: "nucleoside 5'-diphosphatase activity" EXACT [EC:3.6.1.6]
synonym: "nucleoside diphosphatase activity" EXACT []
synonym: "nucleoside diphosphate phosphatase activity" EXACT [EC:3.6.1.6]
synonym: "nucleoside diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.6]
synonym: "nucleoside-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.6]
synonym: "type B nucleoside diphosphatase" NARROW [EC:3.6.1.6]
synonym: "type L nucleoside diphosphatase" NARROW [EC:3.6.1.6]
xref: EC:3.6.1.6
xref: MetaCyc:NUCLEOSIDE-DIPHOSPHATASE-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0017111
name: nucleoside-triphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]
subset: gosubset_prok
synonym: "apyrase activity" BROAD []
synonym: "NTPase activity" EXACT [EC:3.6.1.15]
synonym: "nucleoside 5-triphosphatase activity" EXACT [EC:3.6.1.15]
synonym: "nucleoside triphosphatase activity" EXACT []
synonym: "nucleoside triphosphate hydrolase activity" EXACT [EC:3.6.1.15]
synonym: "nucleoside triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15]
synonym: "nucleoside-5-triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15]
synonym: "unspecific diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15]
xref: EC:3.6.1.15
xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0017112
name: Rab guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity

[Term]
id: GO:0017113
name: dihydropyrimidine dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+." [EC:1.3.1.2]
subset: gosubset_prok
synonym: "4,5-dihydrothymine: oxidoreductase activity" EXACT [EC:1.3.1.2]
synonym: "5,6-dihydrouracil:NADP+ 5-oxidoreductase activity" EXACT [EC:1.3.1.2]
synonym: "dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.2]
synonym: "DHPDH" RELATED [EC:1.3.1.2]
synonym: "DHU dehydrogenase activity" EXACT [EC:1.3.1.2]
synonym: "dihydropyrimidine dehydrogenase activity" EXACT []
synonym: "dihydrothymine dehydrogenase activity" RELATED [EC:1.3.1.2]
synonym: "dihydrouracil dehydrogenase (NADP)" EXACT [EC:1.3.1.2]
synonym: "dihydrouracil dehydrogenase (NADP+) activity" EXACT [EC:1.3.1.2]
synonym: "DPD" RELATED [EC:1.3.1.2]
synonym: "hydropyrimidine dehydrogenase activity" EXACT [EC:1.3.1.2]
xref: EC:1.3.1.2
xref: MetaCyc:1.3.1.2-RXN
xref: Reactome:25636 "dihydropyrimidine dehydrogenase (NADP+) activity"
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0017114
name: wide-spectrum protease inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of a protease by a wide-spectrum protease inhibitor. A wide-spectrum protease inhibitor is a protein having a peptide stretch which contains specific cleavage sites for different proteinases enabling inhibition of all four classes of proteinases by formation of a covalent bond between the inhibitor and the protease." [GOC:dph, GOC:tb]
comment: This term was made obsolete because it represents a regulator of non-existent molecular function.
synonym: "wide-spectrum proteinase inhibitor" EXACT []
is_obsolete: true
replaced_by: GO:0030414

[Term]
id: GO:0017116
name: single-stranded DNA-dependent ATP-dependent DNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [EC:3.6.1.3, GOC:jl]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ssDNA-dependent ATP-dependent DNA helicase activity" EXACT [GOC:mah]
is_a: GO:0004003 ! ATP-dependent DNA helicase activity
is_a: GO:0043142 ! single-stranded DNA-dependent ATPase activity

[Term]
id: GO:0017117
name: single-stranded DNA-dependent ATP-dependent DNA helicase complex
namespace: cellular_component
def: "A protein complex that possesses single-stranded DNA-dependent DNA helicase activity." [GOC:mah]
synonym: "ssDNA-dependent ATP-dependent DNA helicase complex" EXACT [GOC:mah]
is_a: GO:0033202 ! DNA helicase complex

[Term]
id: GO:0017118
name: lipoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of the lipoyl group from lipoyl-AMP to the lysine residue of lipoate-dependent enzyme." [PMID:10103005]
subset: gosubset_prok
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0017119
name: Golgi transport complex
namespace: cellular_component
def: "A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p)." [GOC:krc, PMID:9792665]
synonym: "COG complex" EXACT []
synonym: "conserved oligomeric Golgi complex" EXACT []
synonym: "Sec34/35 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044431 ! Golgi apparatus part

[Term]
id: GO:0017120
name: polyphosphoinositide phosphatase activity
namespace: molecular_function
def: "Catalysis of the conversion of phosphatidylinositol-3-phosphate, phosphatidylinositol-4-phosphate, and phosphatidylinositol-3,5-bisphosphate, but not PI-4,5-bisphosphate, to phosphatidylinositol; PPIPase activity is a key regulator of membrane trafficking and actin cytoskeleton organization." [PMID:10224048]
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0017121
name: phospholipid scrambling
namespace: biological_process
def: "The process by which all major lipid classes are redistributed within the plasma membrane following cell activation or injury, resulting in surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE). Cell surface-exposed PS can serve as receptor sites for coagulation enzyme complexes, and contributes to cell clearance by the reticuloendothelial system." [PMID:11487015]
synonym: "PL scrambling" EXACT []
is_a: GO:0007009 ! plasma membrane organization

[Term]
id: GO:0017122
name: protein N-acetylglucosaminyltransferase complex
namespace: cellular_component
def: "Heterotrimeric enzyme complex, which in humans is composed of two large subunits of the same size, and one smaller subunit. Functions in the addition of nucleotide-activated sugars onto the polypeptide." [PMID:15247246]
synonym: "O-GlcNAc transferase complex" EXACT [GOC:mah]
synonym: "UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase" EXACT [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0017123
name: Ral GTPase activator activity
namespace: molecular_function
def: "Increases the rate of GTP hydrolysis by a GTPase of the Ral family." [GOC:mah]
synonym: "Ral GAP activity" EXACT [GOC:pg]
is_a: GO:0005099 ! Ras GTPase activator activity

[Term]
id: GO:0017124
name: SH3 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0017125
name: deoxycytidyl transferase activity
namespace: molecular_function
alt_id: GO:0019986
def: "Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA." [PMID:10535901]
synonym: "deoxycytidyl transferase activity, template-dependent" NARROW []
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0017126
name: nucleologenesis
namespace: biological_process
def: "The process by which the nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells, is formed and assembled." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "nucleolus assembly" NARROW [GOC:mah]
synonym: "nucleolus biogenesis" EXACT []
is_a: GO:0007000 ! nucleolus organization
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0017127
name: cholesterol transporter activity
namespace: molecular_function
def: "Enables the directed movement of cholesterol into, out of, within or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai]
xref: Reactome:25647 "cholesterol transporter activity"
is_a: GO:0015248 ! sterol transporter activity

[Term]
id: GO:0017128
name: phospholipid scramblase activity
namespace: molecular_function
is_a: GO:0005548 ! phospholipid transporter activity

[Term]
id: GO:0017129
name: triglyceride binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any triester of glycerol." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "triacylglycerol binding" EXACT [GOC:mah]
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0017130
name: poly(C) RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of cytosine residues in an RNA molecule." [GOC:mah]
synonym: "poly(C) binding" BROAD [GOC:mah]
synonym: "poly(rC) binding" EXACT [GOC:mah]
is_a: GO:0008187 ! poly-pyrimidine tract binding

[Term]
id: GO:0017131
name: uridine-rich cytoplasmic polyadenylylation element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with U-rich sequence in the 3'-end of nuclear-transcribed mRNAs; required for cytoplasmic polyadenylylation." [GOC:krc, PMID:7954828]
synonym: "U-rich CPE binding" EXACT [PMID:7954828]
synonym: "uridine-rich cytoplasmic polyadenylation element binding" EXACT []
is_a: GO:0008187 ! poly-pyrimidine tract binding

[Term]
id: GO:0017132
name: cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase; dependent on the presence of a cyclic nucleotide." [GOC:mah, PMID:9856955]
is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity

[Term]
id: GO:0017133
name: mitochondrial electron transfer flavoprotein complex
namespace: cellular_component
def: "A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0044429 ! mitochondrial part
is_a: GO:0045251 ! electron transfer flavoprotein complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0017134
name: fibroblast growth factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with fibroblast growth factor." [PMID:9806903]
synonym: "FGF binding" EXACT []
is_a: GO:0019838 ! growth factor binding

[Term]
id: GO:0017135
name: membrane-associated protein with guanylate kinase activity interacting
namespace: molecular_function
def: "OBSOLETE. The interaction with synapse-associated membrane-associated protein with guanylate kinase activity." [PMID:10207005]
comment: This term was made obsolete because it does not represent a molecular function and the term name appears to make no sense.
is_obsolete: true
consider: GO:0019899

[Term]
id: GO:0017136
name: NAD-dependent histone deacetylase activity
namespace: molecular_function
def: "Catalysis of the removal of one or more acetyl groups from a histone, requiring NAD." [GOC:ai, GOC:mah]
synonym: "SIR2" RELATED []
is_a: GO:0004407 ! histone deacetylase activity
is_a: GO:0034979 ! NAD-dependent protein deacetylase activity

[Term]
id: GO:0017137
name: Rab GTPase binding
namespace: molecular_function
alt_id: GO:0005084
def: "Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
synonym: "Rab escort protein activity" NARROW []
synonym: "Rab interactor activity" RELATED []
synonym: "REP" NARROW []
is_a: GO:0005083 ! small GTPase regulator activity
is_a: GO:0017016 ! Ras GTPase binding

[Term]
id: GO:0017139
name: arsenate sensitivity/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046685

[Term]
id: GO:0017140
name: lipoic acid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: octanoic acid + 2 S = lipoic acid + 2 H." [PMID:11106496, PMID:11389890]
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0017141
name: antibiotic susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046677

[Term]
id: GO:0017142
name: toxin susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0009636

[Term]
id: GO:0017143
name: insecticide metabolic process
namespace: biological_process
alt_id: GO:0017138
def: "The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai]
subset: gosubset_prok
synonym: "insecticide metabolism" EXACT []
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0009404 ! toxin metabolic process
relationship: part_of GO:0017085 ! response to insecticide

[Term]
id: GO:0017144
name: drug metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice." [GOC:cab2]
subset: goslim_pir
subset: gosubset_prok
synonym: "drug metabolism" EXACT []
xref: Reactome:428314 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)"
xref: Reactome:450647 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)"
xref: Reactome:537533 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)"
xref: Reactome:76397 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)"
xref: Wikipedia:Drug_metabolism
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0017145
name: stem cell division
namespace: biological_process
def: "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jic, ISBN:0582227089]
synonym: "stem cell renewal" EXACT []
is_a: GO:0051301 ! cell division

[Term]
id: GO:0017146
name: N-methyl-D-aspartate selective glutamate receptor complex
namespace: cellular_component
def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
synonym: "NMDA-selective glutamate receptor" EXACT []
is_a: GO:0008328 ! ionotropic glutamate receptor complex

[Term]
id: GO:0017147
name: Wnt-protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0017148
name: negative regulation of translation
namespace: biological_process
alt_id: GO:0016478
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]
subset: gosubset_prok
synonym: "down regulation of protein biosynthetic process" EXACT []
synonym: "down-regulation of protein biosynthetic process" EXACT []
synonym: "downregulation of protein biosynthetic process" EXACT []
synonym: "inhibition of protein biosynthetic process" NARROW []
synonym: "negative regulation of protein anabolism" EXACT []
synonym: "negative regulation of protein biosynthesis" EXACT []
synonym: "negative regulation of protein biosynthetic process" EXACT []
synonym: "negative regulation of protein formation" EXACT []
synonym: "negative regulation of protein synthesis" EXACT []
synonym: "protein biosynthesis inhibitor activity" RELATED []
synonym: "protein biosynthetic process inhibitor activity" RELATED []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0032269 ! negative regulation of cellular protein metabolic process
relationship: negatively_regulates GO:0006412 ! translation

[Term]
id: GO:0017149
name: protein biosynthetic process inhibitor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents involvement in a biological process.
synonym: "protein anabolism inhibitor activity" EXACT []
synonym: "protein formation inhibitor activity" EXACT []
synonym: "protein synthesis inhibitor activity" EXACT []
is_obsolete: true
replaced_by: GO:0017148

[Term]
id: GO:0017150
name: tRNA dihydrouridine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710]
subset: gosubset_prok
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0017151
name: DEAD/H-box RNA helicase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase." [GOC:jl]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0017153
name: sodium:dicarboxylate symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]
subset: gosubset_prok
synonym: "sodium:dicarboxylate cotransporter activity" BROAD []
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity
is_a: GO:0005343 ! organic acid:sodium symporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0017154
name: semaphorin receptor activity
namespace: molecular_function
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0017155
name: sodium:hydrogen antiporter regulator activity
namespace: molecular_function
alt_id: GO:0030040
def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because it represents a biological process.
synonym: "sodium:proton antiporter regulator" EXACT []
is_obsolete: true

[Term]
id: GO:0017156
name: calcium ion-dependent exocytosis
namespace: biological_process
def: "The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, requiring the presence of calcium ions." [GOC:go_curators]
is_a: GO:0006887 ! exocytosis

[Term]
id: GO:0017157
name: regulation of exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0060341 ! regulation of cellular localization
is_a: GO:0060627 ! regulation of vesicle-mediated transport
relationship: regulates GO:0006887 ! exocytosis

[Term]
id: GO:0017158
name: regulation of calcium ion-dependent exocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]
is_a: GO:0017157 ! regulation of exocytosis
relationship: regulates GO:0017156 ! calcium ion-dependent exocytosis

[Term]
id: GO:0017159
name: pantetheine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol." [EC:3.5.1.92]
synonym: "(R)-pantetheine amidohydrolase activity" EXACT [EC:3.5.1.92]
synonym: "pantetheinase activity" EXACT [EC:3.5.1.92]
synonym: "vanin" RELATED [EC:3.5.1.92]
synonym: "vanin-1" RELATED [EC:3.5.1.92]
xref: EC:3.5.1.92
xref: MetaCyc:3.5.1.92-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0017160
name: Ral GTPase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]
synonym: "Ral interactor activity" RELATED []
is_a: GO:0017016 ! Ras GTPase binding

[Term]
id: GO:0017161
name: inositol-1,3,4-trisphosphate 4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate." [GOC:ai]
xref: EC:3.1.3.-
is_a: GO:0046030 ! inositol trisphosphate phosphatase activity

[Term]
id: GO:0017162
name: aryl hydrocarbon receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an aryl hydrocarbon receptor." [GOC:ai]
is_a: GO:0005102 ! receptor binding
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0017163
name: basal transcription repressor activity
namespace: molecular_function
def: "Any transcription regulator activity that prevents or downregulates basal transcription. Basal transcription results from transcription that is controlled by the minimal complement of proteins necessary to reconstitute transcription from a minimal promoter." [GOC:dph, GOC:tb, http://tfib.med.harvard.edu/transcription/basaltx.html]
subset: gosubset_prok
is_a: GO:0016564 ! transcription repressor activity

[Term]
id: GO:0017164
name: nicotinic acetylcholine receptor-associated protein activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product and not a molecular function.
is_obsolete: true
consider: GO:0005102
consider: GO:0005515

[Term]
id: GO:0017165
name: dipeptidase E activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides." [EC:3.4.13.21]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "alpha-aspartyl dipeptidase activity" EXACT []
synonym: "aspartyl dipeptidase activity" EXACT [EC:3.4.13.21]
synonym: "PepE gene product (Salmonella typhimurium) activity" NARROW [EC:3.4.13.21]
synonym: "peptidase E activity" BROAD [EC:3.4.13.21]
xref: EC:3.4.13.21
xref: MetaCyc:3.4.13.21-RXN
is_obsolete: true
replaced_by: GO:0016805

[Term]
id: GO:0017166
name: vinculin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0017168
name: 5-oxoprolinase (ATP-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate." [EC:3.5.2.9]
subset: gosubset_prok
synonym: "5-OPase activity" EXACT [EC:3.5.2.9]
synonym: "5-oxo-L-prolinase activity" EXACT [EC:3.5.2.9]
synonym: "5-oxo-L-proline amidohydrolase (ATP-hydrolysing)" EXACT [EC:3.5.2.9]
synonym: "5-oxoprolinase (ATP-hydrolysing)" EXACT [EC:3.5.2.9]
synonym: "5-oxoprolinase activity" EXACT [EC:3.5.2.9]
synonym: "L-pyroglutamate hydrolase activity" EXACT [EC:3.5.2.9]
synonym: "oxoprolinase activity" EXACT [EC:3.5.2.9]
synonym: "pyroglutamase (ATP-hydrolysing)" EXACT [EC:3.5.2.9]
synonym: "pyroglutamase (ATP-hydrolyzing) activity" EXACT [EC:3.5.2.9]
synonym: "pyroglutamase activity" EXACT [EC:3.5.2.9]
synonym: "pyroglutamate hydrolase activity" EXACT [EC:3.5.2.9]
synonym: "pyroglutamic hydrolase activity" EXACT [EC:3.5.2.9]
xref: EC:3.5.2.9
xref: MetaCyc:5-OXOPROLINASE-ATP-HYDROLYSING-RXN
xref: Wikipedia:5-oxoprolinase_(ATP-hydrolysing)
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0017169
name: CDP-alcohol phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol." [GOC:ai]
subset: gosubset_prok
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0017170
name: KU70 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Ku70, a protein involved in non-homologous DNA end joining." [GOC:mah, PMID:14739985]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0017171
name: serine hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [Wikipedia:Serine_hydrolase]
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0017172
name: cysteine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + O2 = 3-sulfinoalanine." [EC:1.13.11.20]
subset: gosubset_prok
xref: EC:1.13.11.20
xref: MetaCyc:CYSTEINE-DIOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0017173
name: DRAP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate." [GOC:jl, MetaCyc:YOL066C-MONOMER]
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0017174
name: glycine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine." [EC:2.1.1.20]
synonym: "glycine methyltransferase activity" EXACT [EC:2.1.1.20]
synonym: "GNMT" RELATED [EC:2.1.1.20]
synonym: "S-adenosyl-L-methionine:glycine methyltransferase activity" EXACT [EC:2.1.1.20]
synonym: "S-adenosyl-L-methionine:glycine N-methyltransferase activity" EXACT [EC:2.1.1.20]
xref: EC:2.1.1.20
xref: MetaCyc:GLYCINE-N-METHYLTRANSFERASE-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0017175
name: IMP-GMP specific 5'-nucleotidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the conversion of 5'-ribonucleotides to ribonucleosides and phosphate, with specificity for IMP or GMP 5'-ribonucleotides and H2O as a nucleophile." [EC:3.1.3.5, GOC:krc]
comment: This term was made obsolete because it represents a gene product with two different activities.
is_obsolete: true
consider: GO:0050484

[Term]
id: GO:0017176
name: phosphatidylinositol N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198]
synonym: "UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase activity" EXACT [EC:2.4.1.198]
synonym: "UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198]
synonym: "uridine diphosphoacetylglucosamine alpha-1,6-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198]
synonym: "uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198]
xref: EC:2.4.1.198
xref: MetaCyc:2.4.1.198-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0017177
name: alpha-glucosidase II complex
namespace: cellular_component
def: "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335]
comment: Note that alpha-glucosidase I functions as a monomer, and therefore does not have a corresponding cellular component term.
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0017178
name: diphthine-ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + diphthine + NH3 = ADP + phosphate + diphthamide." [EC:6.3.2.22]
synonym: "diphthamide synthase activity" EXACT [EC:6.3.2.22]
synonym: "diphthamide synthetase activity" EXACT [EC:6.3.2.22]
synonym: "diphthine:ammonia ligase (ADP-forming)" EXACT [EC:6.3.2.22]
xref: EC:6.3.2.22
xref: MetaCyc:DIPHTINE--AMMONIA-LIGASE-RXN
is_a: GO:0016211 ! ammonia ligase activity

[Term]
id: GO:0017179
name: peptidyl-diphthine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving peptidyl-diphthine, a modified histidine residue." [GOC:go_curators]
subset: gosubset_prok
synonym: "peptidyl-diphthine metabolism" EXACT []
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0017180
name: peptidyl-diphthine biosynthetic process from peptidyl-histidine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptidyl-diphthine from other compounds, including peptidyl-histidine." [GOC:go_curators]
subset: gosubset_prok
synonym: "peptidyl-diphthine anabolism from peptidyl-histidine" EXACT []
synonym: "peptidyl-diphthine formation from peptidyl-histidine" EXACT []
synonym: "peptidyl-diphthine synthesis from peptidyl-histidine" EXACT []
is_a: GO:0017179 ! peptidyl-diphthine metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0017181
name: peptidyl-diphthine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthine, a modified histidine residue." [GOC:go_curators]
subset: gosubset_prok
synonym: "peptidyl-diphthine breakdown" EXACT []
synonym: "peptidyl-diphthine catabolism" EXACT []
synonym: "peptidyl-diphthine degradation" EXACT []
is_a: GO:0017179 ! peptidyl-diphthine metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0017182
name: peptidyl-diphthamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators]
subset: gosubset_prok
synonym: "peptidyl-diphthamide metabolism" EXACT []
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0017183
name: peptidyl-diphthamide biosynthetic process from peptidyl-histidine
namespace: biological_process
def: "The posttranslational modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor eEF-2." [RESID:AA0040]
subset: gosubset_prok
synonym: "peptidyl-diphthamide anabolism from peptidyl-histidine" EXACT []
synonym: "peptidyl-diphthamide formation from peptidyl-histidine" EXACT []
synonym: "peptidyl-diphthamide synthesis from peptidyl-histidine" EXACT []
xref: RESID:AA0040
is_a: GO:0017182 ! peptidyl-diphthamide metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0017184
name: peptidyl-diphthamide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators]
subset: gosubset_prok
synonym: "peptidyl-diphthamide breakdown" EXACT []
synonym: "peptidyl-diphthamide catabolism" EXACT []
synonym: "peptidyl-diphthamide degradation" EXACT []
is_a: GO:0017182 ! peptidyl-diphthamide metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0017185
name: peptidyl-lysine hydroxylation
namespace: biological_process
def: "The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018126 ! protein amino acid hydroxylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0017186
name: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase." [RESID:AA0031]
comment: See also the molecular function term 'glutaminyl-peptide cyclotransferase activity ; GO:0016603'.
subset: gosubset_prok
synonym: "2-pyrrolidone-5-carboxylic acid biosynthesis" EXACT []
synonym: "2-pyrrolidone-5-carboxylic acid biosynthetic process" EXACT []
synonym: "peptidyl-pyroglutamic acid anabolism, using glutaminyl-peptide cyclotransferase" EXACT []
synonym: "peptidyl-pyroglutamic acid formation, using glutaminyl-peptide cyclotransferase" EXACT []
synonym: "peptidyl-pyroglutamic acid synthesis, using glutaminyl-peptide cyclotransferase" EXACT []
xref: RESID:AA0031
is_a: GO:0018199 ! peptidyl-glutamine modification

[Term]
id: GO:0017187
name: peptidyl-glutamic acid carboxylation
namespace: biological_process
def: "The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032]
comment: See also the molecular function term 'gamma-glutamyl carboxylase activity ; GO:0008488'.
subset: gosubset_prok
xref: Reactome:159740 "Gamma-carboxylation of protein precursors"
xref: Reactome:159854 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins"
xref: Reactome:449260 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins"
xref: Reactome:449262 "Gamma-carboxylation of protein precursors"
xref: Reactome:470379 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins"
xref: Reactome:470381 "Gamma-carboxylation of protein precursors"
xref: Reactome:488061 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins"
xref: Reactome:508018 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins"
xref: Reactome:508020 "Gamma-carboxylation of protein precursors"
xref: Reactome:517879 "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins"
xref: Reactome:517881 "Gamma-carboxylation of protein precursors"
xref: RESID:AA0032
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018214 ! protein amino acid carboxylation

[Term]
id: GO:0017188
name: aspartate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + L-aspartate = CoA + N-acetyl-L-aspartate." [EC:2.3.1.17]
synonym: "acetyl-CoA:L-aspartate N-acetyltransferase activity" EXACT [EC:2.3.1.17]
synonym: "aspartate acetyltransferase activity" EXACT [EC:2.3.1.17]
synonym: "L-aspartate N-acetyltransferase activity" EXACT [EC:2.3.1.17]
xref: EC:2.3.1.17
xref: MetaCyc:ASPARTATE-N-ACETYLTRANSFERASE-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0017189
name: N-terminal peptidyl-alanine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal alanine of proteins; catalyzed by peptide alpha-N-acetyltransferase or other enzymes of this class, such as ribosomal-protein-alanine N-acetyltransferase." [RESID:AA0041]
comment: See also the molecular function terms 'peptide alpha-N-acetyltransferase activity ; GO:0004596' and 'ribosomal-protein-alanine N-acetyltransferase activity ; GO:0008999'.
subset: gosubset_prok
xref: RESID:AA0041
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018194 ! peptidyl-alanine modification

[Term]
id: GO:0017190
name: N-terminal peptidyl-aspartic acid acetylation
namespace: biological_process
def: "The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase." [RESID:AA0042]
comment: See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'.
subset: gosubset_prok
xref: RESID:AA0042
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0017192
name: N-terminal peptidyl-glutamine acetylation
namespace: biological_process
def: "The acetylation of a glutamine residue in protein to form the N5-methyl-L-glutamine derivative. The occurrence of this modification has not been confirmed. Its annotation in sequence databases is either due to the misidentification of 2-pyrrolidone-5-carboxylic acid, or to inappropriate homolog comparisons when proteolytic modification is more probable." [RESID:AA0045]
subset: gosubset_prok
xref: RESID:AA0045
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018199 ! peptidyl-glutamine modification

[Term]
id: GO:0017193
name: N-terminal peptidyl-glycine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal glycine of proteins to form the derivative N-acetylglycine." [RESID:AA0046]
subset: gosubset_prok
xref: RESID:AA0046
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0017194
name: N-terminal peptidyl-isoleucine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal isoleucine of proteins to form the derivative N-acetyl-L-isoleucine. The occurrence of this modification has not been confirmed." [RESID:AA0047]
subset: gosubset_prok
xref: RESID:AA0047
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018203 ! peptidyl-isoleucine modification

[Term]
id: GO:0017195
name: N-terminal peptidyl-lysine N2-acetylation
namespace: biological_process
def: "The acetylation of the N-terminal lysine of proteins to form the derivative N2-acetyl-L-lysine." [RESID:AA0048]
subset: gosubset_prok
xref: RESID:AA0048
is_a: GO:0018076 ! N-terminal peptidyl-lysine acetylation

[Term]
id: GO:0017196
name: N-terminal peptidyl-methionine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine." [RESID:AA0049]
subset: gosubset_prok
xref: RESID:AA0049
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018206 ! peptidyl-methionine modification

[Term]
id: GO:0017197
name: N-terminal peptidyl-proline acetylation
namespace: biological_process
def: "The acetylation of the N-terminal proline of proteins to form the derivative N-acetyl-L-proline." [RESID:AA0050]
subset: gosubset_prok
xref: RESID:AA0050
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0017198
name: N-terminal peptidyl-serine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal serine of proteins to form the derivative N-acetyl-L-serine." [RESID:AA0051]
subset: gosubset_prok
xref: RESID:AA0051
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0030920 ! peptidyl-serine acetylation

[Term]
id: GO:0017199
name: N-terminal peptidyl-threonine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal threonine of proteins to form the derivative N-acetyl-L-threonine; catalyzed by peptide alpha-N-acetyltransferase." [RESID:AA0052]
comment: See also the molecular function term 'peptide alpha-N-acetyltransferase activity ; GO:0004596'.
subset: gosubset_prok
xref: RESID:AA0052
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018000
name: N-terminal peptidyl-tyrosine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-tyrosine." [RESID:AA0053]
subset: gosubset_prok
xref: RESID:AA0053
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018001
name: N-terminal peptidyl-valine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-valine." [RESID:AA0054]
subset: gosubset_prok
xref: RESID:AA0054
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018213 ! peptidyl-valine modification

[Term]
id: GO:0018002
name: N-terminal peptidyl-glutamic acid acetylation
namespace: biological_process
def: "The acetylation of the N-terminal glutamic acid of proteins; catalyzed by peptide alpha-N-acetyltransferase." [RESID:AA0044]
comment: See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'.
subset: gosubset_prok
xref: RESID:AA0044
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018003
name: peptidyl-lysine N6-acetylation
namespace: biological_process
def: "The acetylation of the peptidyl-lysine of proteins to form the derivative peptidyl-N6-acetyl-L-lysine; catalyzed by tubulin N-acetyltransferase." [RESID:AA0055]
comment: See also the molecular function term 'tubulin N-acetyltransferase activity ; GO:0019799'.
subset: gosubset_prok
xref: RESID:AA0055
is_a: GO:0018393 ! internal peptidyl-lysine acetylation

[Term]
id: GO:0018004
name: N-terminal protein formylation
namespace: biological_process
def: "The formylation of the N-terminal amino acid of proteins." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018256 ! protein amino acid formylation
is_a: GO:0018409 ! peptide or protein amino-terminal blocking

[Term]
id: GO:0018005
name: N-terminal peptidyl-glycine N-formylation
namespace: biological_process
def: "The formylation of the N-terminal glycine of proteins to form the derivative N-formylglycine." [RESID:AA0057]
subset: gosubset_prok
xref: RESID:AA0057
is_a: GO:0018004 ! N-terminal protein formylation
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018006
name: N-terminal protein amino acid glucuronylation
namespace: biological_process
def: "The glucuronylation of the N-terminal amino acid of proteins." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018321 ! protein amino acid glucuronylation
is_a: GO:0018409 ! peptide or protein amino-terminal blocking

[Term]
id: GO:0018007
name: N-terminal peptidyl-glycine N-glucuronylation
namespace: biological_process
def: "The glucuronylation of the N-terminal glycine of proteins to form the derivative D-glucuronyl-N-glycine." [RESID:AA0058]
subset: gosubset_prok
xref: RESID:AA0058
is_a: GO:0018006 ! N-terminal protein amino acid glucuronylation
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018008
name: N-terminal peptidyl-glycine N-myristoylation
namespace: biological_process
def: "The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine." [RESID:AA0059]
subset: gosubset_prok
synonym: "N-terminal peptidyl-glycine N-myristylation" EXACT []
xref: RESID:AA0059
is_a: GO:0006499 ! N-terminal protein myristoylation
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018009
name: N-terminal peptidyl-L-cysteine N-palmitoylation
namespace: biological_process
def: "The palmitoylation of the N-terminal cysteine of proteins to form the derivative N-palmitoyl-cysteine." [RESID:AA0060]
subset: gosubset_prok
xref: RESID:AA0060
is_a: GO:0006500 ! N-terminal protein palmitoylation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018010
name: glycoprotein N-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + glycoprotein = CoA + N-palmitoylglycoprotein." [EC:2.3.1.96]
synonym: "mucus glycoprotein fatty acyltransferase" NARROW [EC:2.3.1.96]
synonym: "palmitoyl-CoA:glycoprotein N-palmitoyltransferase activity" EXACT [EC:2.3.1.96]
xref: EC:2.3.1.96
xref: MetaCyc:GLYCOPROTEIN-N-PALMITOYLTRANSFERASE-RXN
is_a: GO:0019105 ! N-palmitoyltransferase activity

[Term]
id: GO:0018011
name: N-terminal peptidyl-alanine methylation
namespace: biological_process
def: "The methylation of the N-terminal alanine of proteins." [RESID:AA0061, RESID:AA0062]
subset: gosubset_prok
xref: RESID:AA0061
xref: RESID:AA0062
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018194 ! peptidyl-alanine modification

[Term]
id: GO:0018012
name: N-terminal peptidyl-alanine trimethylation
namespace: biological_process
def: "The trimethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N,N,N-trimethyl-L-alanine." [RESID:AA0062]
subset: gosubset_prok
xref: RESID:AA0062
is_a: GO:0018011 ! N-terminal peptidyl-alanine methylation

[Term]
id: GO:0018013
name: N-terminal peptidyl-glycine methylation
namespace: biological_process
def: "The methylation of the N-terminal glycine of proteins to form the derivative N-methylglycine." [RESID:AA0063]
subset: gosubset_prok
xref: RESID:AA0063
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018014
name: N-terminal peptidyl-methionine methylation
namespace: biological_process
def: "The methylation of the N-terminal methionine of proteins to form the derivative N-methyl-L-methionine." [RESID:AA0064]
subset: gosubset_prok
xref: RESID:AA0064
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018206 ! peptidyl-methionine modification

[Term]
id: GO:0018015
name: N-terminal peptidyl-phenylalanine methylation
namespace: biological_process
def: "The methylation of the N-terminal phenylalanine of proteins to form the derivative N-methyl-L-phenylalanine." [RESID:AA0065]
subset: gosubset_prok
xref: RESID:AA0065
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018207 ! peptidyl-phenylalanine modification

[Term]
id: GO:0018016
name: N-terminal peptidyl-proline dimethylation
namespace: biological_process
def: "The methylation of the N-terminal proline of proteins to form the derivative N,N-dimethyl-L-proline." [RESID:AA0066]
subset: gosubset_prok
xref: RESID:AA0066
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0018019
name: N-terminal peptidyl-glutamine methylation
namespace: biological_process
def: "The methylation of a glutamine residue in proteins to form the peptidyl-N5-methyl-L-glutamine derivative." [RESID:AA0071]
subset: gosubset_prok
xref: RESID:AA0071
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018199 ! peptidyl-glutamine modification

[Term]
id: GO:0018020
name: peptidyl-glutamic acid methylation
namespace: biological_process
def: "The addition of a methyl group to a glutamic acid residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006479 ! protein amino acid methylation

[Term]
id: GO:0018021
name: peptidyl-histidine methylation
namespace: biological_process
def: "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073, RESID:AA0317]
subset: gosubset_prok
xref: RESID:AA0073
xref: RESID:AA0317
is_a: GO:0006479 ! protein amino acid methylation
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0018022
name: peptidyl-lysine methylation
namespace: biological_process
def: "The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006479 ! protein amino acid methylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018023
name: peptidyl-lysine trimethylation
namespace: biological_process
def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine." [RESID:AA0074]
subset: gosubset_prok
xref: RESID:AA0074
is_a: GO:0018022 ! peptidyl-lysine methylation

[Term]
id: GO:0018024
name: histone-lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]
synonym: "histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity" EXACT [EC:2.1.1.43]
synonym: "histone-lysine N-methylase activity" EXACT [GOC:mah]
synonym: "protein (lysine) methyltransferase activity" EXACT [EC:2.1.1.43]
synonym: "protein methylase 3 activity" NARROW [EC:2.1.1.43]
synonym: "protein methylase III activity" NARROW [EC:2.1.1.43]
synonym: "protein methyltransferase II activity" NARROW [EC:2.1.1.43]
synonym: "S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.43]
synonym: "S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.43]
xref: EC:2.1.1.43
xref: MetaCyc:HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN
xref: RESID:AA0074
xref: RESID:AA0075
xref: RESID:AA0076
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity
is_a: GO:0042054 ! histone methyltransferase activity

[Term]
id: GO:0018025
name: calmodulin-lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine." [EC:2.1.1.60]
synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.60]
synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.60]
synonym: "S-adenosylmethionine:calmodulin (lysine) N-methyltransferase activity" EXACT [EC:2.1.1.60]
xref: EC:2.1.1.60
xref: MetaCyc:2.1.1.60-RXN
is_a: GO:0016279 ! protein-lysine N-methyltransferase activity

[Term]
id: GO:0018026
name: peptidyl-lysine monomethylation
namespace: biological_process
def: "The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine." [RESID:AA0076]
subset: gosubset_prok
xref: RESID:AA0076
is_a: GO:0018022 ! peptidyl-lysine methylation

[Term]
id: GO:0018027
name: peptidyl-lysine dimethylation
namespace: biological_process
def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine." [RESID:AA0075]
subset: gosubset_prok
xref: RESID:AA0075
is_a: GO:0018022 ! peptidyl-lysine methylation

[Term]
id: GO:0018028
name: peptidyl-lysine myristoylation
namespace: biological_process
def: "The myristoylation of peptidyl-lysine to form peptidyl-N6-myristoyl-L-lysine." [RESID:AA0078]
subset: gosubset_prok
synonym: "peptidyl-lysine myristylation" EXACT []
xref: RESID:AA0078
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018319 ! protein amino acid myristoylation

[Term]
id: GO:0018029
name: peptidyl-lysine palmitoylation
namespace: biological_process
def: "The palmitoylation of peptidyl-lysine to form peptidyl-N6-palmitoyl-L-lysine." [RESID:AA0077]
subset: gosubset_prok
xref: RESID:AA0077
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018030
name: peptidyl-lysine N6-myristoyltransferase activity
namespace: molecular_function
xref: EC:2.3.1.-
is_a: GO:0004379 ! glycylpeptide N-tetradecanoyltransferase activity

[Term]
id: GO:0018031
name: peptidyl-lysine N6-palmitoyltransferase activity
namespace: molecular_function
xref: EC:2.3.1.-
is_a: GO:0019105 ! N-palmitoyltransferase activity

[Term]
id: GO:0018032
name: protein amino acid amidation
namespace: biological_process
def: "Addition of an amide group from a glycine to a protein amino acid." [SP_KW:KW-0027]
subset: gosubset_prok
is_a: GO:0006464 ! protein modification process

[Term]
id: GO:0018033
name: protein C-terminal amidation
namespace: biological_process
def: "The formation of a C-terminal amide by hydrolysis and oxidation of an interior peptide in a secreted protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018032 ! protein amino acid amidation
is_a: GO:0018410 ! peptide or protein carboxyl-terminal blocking

[Term]
id: GO:0018034
name: C-terminal peptidyl-alanine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-alanine amide by hydrolysis and oxidation of an interior Ala-Gly peptide in a secreted protein." [RESID:AA0081]
subset: gosubset_prok
xref: RESID:AA0081
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018194 ! peptidyl-alanine modification

[Term]
id: GO:0018035
name: C-terminal peptidyl-arginine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-arginine amide by hydrolysis and oxidation of an interior Arg-Gly peptide in a secreted protein." [RESID:AA0082]
subset: gosubset_prok
xref: RESID:AA0082
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0018036
name: C-terminal peptidyl-asparagine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-asparagine amide by hydrolysis and oxidation of an interior Asn-Gly peptide in a secreted protein." [RESID:AA0083]
subset: gosubset_prok
xref: RESID:AA0083
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0018037
name: C-terminal peptidyl-aspartic acid amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-aspartic acid 1-amide by hydrolysis and oxidation of an interior Asp-Gly peptide in a secreted protein." [RESID:AA0084]
subset: gosubset_prok
xref: RESID:AA0084
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0018038
name: C-terminal peptidyl-cysteine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-cysteine amide by hydrolysis and oxidation of an interior Cys-Gly peptide in a secreted protein." [RESID:AA0085]
subset: gosubset_prok
xref: RESID:AA0085
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018039
name: C-terminal peptidyl-glutamine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-glutamine amide by hydrolysis and oxidation of an interior Gln-Gly peptide in a secreted protein." [RESID:AA0086]
subset: gosubset_prok
xref: RESID:AA0086
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018199 ! peptidyl-glutamine modification

[Term]
id: GO:0018040
name: C-terminal peptidyl-glutamic acid amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-glutamic acid amide by hydrolysis and oxidation of an interior Glu-Gly peptide in a secreted protein." [RESID:AA0087]
subset: gosubset_prok
xref: RESID:AA0087
is_a: GO:0018033 ! protein C-terminal amidation

[Term]
id: GO:0018041
name: C-terminal peptidyl-glycine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-glycine acid amide by hydrolysis and oxidation of an interior Gly-Gly peptide in a secreted protein." [RESID:AA0088]
subset: gosubset_prok
xref: RESID:AA0088
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018042
name: C-terminal peptidyl-histidine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-histidine amide by hydrolysis and oxidation of an interior His-Gly peptide in a secreted protein." [RESID:AA0089]
subset: gosubset_prok
xref: RESID:AA0089
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0018043
name: C-terminal peptidyl-isoleucine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-isoleucine amide by hydrolysis and oxidation of an interior Ile-Gly peptide in a secreted protein." [RESID:AA0090]
subset: gosubset_prok
xref: RESID:AA0090
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018203 ! peptidyl-isoleucine modification

[Term]
id: GO:0018044
name: C-terminal peptidyl-leucine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-leucine amide by hydrolysis and oxidation of an interior Leu-Gly peptide in a secreted protein." [RESID:AA0091]
subset: gosubset_prok
xref: RESID:AA0091
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018204 ! peptidyl-leucine modification

[Term]
id: GO:0018045
name: C-terminal peptidyl-lysine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-lysine amide by hydrolysis and oxidation of an interior Lys-Gly peptide in a secreted protein." [RESID:AA0092]
subset: gosubset_prok
xref: RESID:AA0092
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018046
name: C-terminal peptidyl-methionine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-methionine amide by hydrolysis and oxidation of an interior Met-Gly peptide in a secreted protein." [RESID:AA0093]
subset: gosubset_prok
xref: RESID:AA0093
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018206 ! peptidyl-methionine modification

[Term]
id: GO:0018047
name: C-terminal peptidyl-phenylalanine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-phenylalanine amide by hydrolysis and oxidation of an interior Phe-Gly peptide in a secreted protein." [RESID:AA0094]
subset: gosubset_prok
xref: RESID:AA0094
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018207 ! peptidyl-phenylalanine modification

[Term]
id: GO:0018048
name: C-terminal peptidyl-proline amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-proline amide by hydrolysis and oxidation of an interior Pro-Gly peptide in a secreted protein." [RESID:AA0095]
subset: gosubset_prok
xref: RESID:AA0095
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0018049
name: C-terminal peptidyl-serine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-serine amide by hydrolysis and oxidation of an interior Ser-Gly peptide in a secreted protein." [RESID:AA0096]
subset: gosubset_prok
xref: RESID:AA0096
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018050
name: C-terminal peptidyl-threonine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-threonine amide by hydrolysis and oxidation of an interior Thr-Gly peptide in a secreted protein." [RESID:AA0097]
subset: gosubset_prok
xref: RESID:AA0097
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018051
name: C-terminal peptidyl-tryptophan amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-tryptophan amide by hydrolysis and oxidation of an interior Trp-Gly peptide in a secreted protein." [RESID:AA0098]
subset: gosubset_prok
xref: RESID:AA0098
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018211 ! peptidyl-tryptophan modification

[Term]
id: GO:0018052
name: C-terminal peptidyl-tyrosine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-tyrosine amide by hydrolysis and oxidation of an interior Tyr-Gly peptide in a secreted protein." [RESID:AA0099]
subset: gosubset_prok
xref: RESID:AA0099
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018053
name: C-terminal peptidyl-valine amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-valine amide by hydrolysis and oxidation of an interior Val-Gly peptide in a secreted protein." [RESID:AA0100]
subset: gosubset_prok
xref: RESID:AA0100
is_a: GO:0018033 ! protein C-terminal amidation
is_a: GO:0018213 ! peptidyl-valine modification

[Term]
id: GO:0018054
name: peptidyl-lysine biotinylation
namespace: biological_process
def: "The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117]
subset: gosubset_prok
xref: RESID:AA0117
is_a: GO:0009305 ! protein amino acid biotinylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018055
name: peptidyl-lysine lipoylation
namespace: biological_process
def: "The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine." [RESID:AA0118]
subset: gosubset_prok
xref: RESID:AA0118
is_a: GO:0009249 ! protein lipoylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018057
name: peptidyl-lysine oxidation
namespace: biological_process
def: "The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens." [ISBN:0198547684, RESID:AA0121]
subset: gosubset_prok
xref: RESID:AA0121
is_a: GO:0018158 ! protein amino acid oxidation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018058
name: N-terminal protein amino acid deamination, from amino carbon
namespace: biological_process
def: "The oxidative deamination of the alpha carbon of an encoded N-terminal amino acid, to form pyruvic acid retaining an amide bond between its 1-carboxyl group and the adjacent residue. The pyruvate 2-oxo group may become an enzyme active site, or it may be reduced to an alcohol." [RESID:AA0127, RESID:AA0128, RESID:AA0129]
subset: gosubset_prok
xref: RESID:AA0127
xref: RESID:AA0128
xref: RESID:AA0129
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018277 ! protein amino acid deamination
is_a: GO:0018409 ! peptide or protein amino-terminal blocking
is_a: GO:0031363 ! N-terminal protein amino acid deamination

[Term]
id: GO:0018059
name: N-terminal peptidyl-serine deamination
namespace: biological_process
subset: gosubset_prok
is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon

[Term]
id: GO:0018060
name: N-terminal peptidyl-cysteine deamination
namespace: biological_process
subset: gosubset_prok
is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon

[Term]
id: GO:0018061
name: peptidyl-L-3-phenyllactic acid biosynthetic process from peptidyl-phenylalanine
namespace: biological_process
def: "The posttranslational modification of a N-terminal peptidyl-phenylalanine residue by either oxidative deamination or by transamination and subsequent reduction to form peptidyl-L-3-phenyllactic acid." [RESID:AA0128]
subset: gosubset_prok
synonym: "peptidyl-L-3-phenyllactic acid anabolism from peptidyl-phenylalanine" EXACT []
synonym: "peptidyl-L-3-phenyllactic acid formation from peptidyl-phenylalanine" EXACT []
synonym: "peptidyl-L-3-phenyllactic acid synthesis from peptidyl-phenylalanine" EXACT []
xref: RESID:AA0128
is_a: GO:0018207 ! peptidyl-phenylalanine modification

[Term]
id: GO:0018062
name: peptidyl-tryptophan succinylation
namespace: biological_process
def: "The posttranslational modification of an N-terminal peptidyl-tryptophan residue to form peptidyl-N2-succinyl-L-tryptophan." [RESID:AA0130]
subset: gosubset_prok
xref: RESID:AA0130
is_a: GO:0018211 ! peptidyl-tryptophan modification
is_a: GO:0018335 ! protein amino acid succinylation

[Term]
id: GO:0018063
name: cytochrome c-heme linkage
namespace: biological_process
def: "The linkage of cytochromes and other heme proteins to heme." [RESID:AA0134, RESID:AA0135]
subset: gosubset_prok
synonym: "cytochrome c-haem linkage" EXACT []
xref: RESID:AA0134
xref: RESID:AA0135
is_a: GO:0017003 ! protein-heme linkage
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0018064
name: protein-histidine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N-methyl-L-histidine." [EC:2.1.1.85]
synonym: "actin-specific histidine methyltransferase activity" EXACT [EC:2.1.1.85]
synonym: "peptidyl-histidine N-methyltransferase activity" EXACT []
synonym: "protein (histidine) methyltransferase activity" EXACT [EC:2.1.1.85]
synonym: "protein methylase IV activity" NARROW [EC:2.1.1.85]
synonym: "S-adenosyl methionine:protein-histidine N-methyltransferase activity" EXACT [EC:2.1.1.85]
synonym: "S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase activity" EXACT [EC:2.1.1.85]
xref: EC:2.1.1.85
xref: MetaCyc:2.1.1.85-RXN
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0018065
name: protein-cofactor linkage
namespace: biological_process
def: "The covalent linking of a cofactor to a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018067
name: peptidyl-L-3',4'-dihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine
namespace: biological_process
def: "The posttranslational modification of protein tyrosine to peptidyl-L-3',4'-dihydroxyphenylalanine (DOPA)." [RESID:AA0146]
subset: gosubset_prok
synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine anabolism from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine formation from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine synthesis from peptidyl-tyrosine" EXACT []
xref: RESID:AA0146
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0018336 ! peptidyl-tyrosine hydroxylation

[Term]
id: GO:0018068
name: peptidyl-L-2',4',5'-topaquinone biosynthetic process from peptidyl-tyrosine
namespace: biological_process
def: "The posttranslational modification of protein tyrosine to L-2',4',5'-topaquinone, characteristic of the active site of copper amine oxidases." [RESID:AA0147]
subset: gosubset_prok
synonym: "peptidyl-L-2',4',5'-topaquinone anabolism from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-2',4',5'-topaquinone formation from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-2',4',5'-topaquinone synthesis from peptidyl-tyrosine" EXACT []
xref: RESID:AA0147
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018069
name: peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone
namespace: biological_process
def: "The posttranslational cross-linking of a tryptophan residue to tryptophyl quinone to form 4'-(L-tryptophan)-L-tryptophyl quinone, a cofactor found at the active site of methylamine dehydrogenase." [RESID:AA0149]
subset: gosubset_prok
xref: RESID:AA0149
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018211 ! peptidyl-tryptophan modification

[Term]
id: GO:0018070
name: peptidyl-serine phosphopantetheinylation
namespace: biological_process
def: "The posttranslational phosphopantetheinylation of peptidyl-serine to form peptidyl-O-phosphopantetheine-L-serine." [RESID:AA0150]
subset: gosubset_prok
xref: RESID:AA0150
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018215 ! protein amino acid phosphopantetheinylation

[Term]
id: GO:0018071
name: NAD(P)-cysteine ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine." [EC:2.4.2.-]
xref: EC:2.4.2.-
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0018072
name: peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine biosynthetic process from peptidyl-glutamic acid
namespace: biological_process
def: "The posttranslational modification of peptidyl-glutamic acid residues by the covalent attachment of ethanolamine, itself further modified by the addition of a phosphoglycerol unit." [PMID:2569467, RESID:AA0170]
subset: gosubset_prok
synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine anabolism from peptidyl-glutamic acid" EXACT []
synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine formation from peptidyl-glutamic acid" EXACT []
synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine synthesis from peptidyl-glutamic acid" EXACT []
xref: RESID:AA0170
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018073
name: protein amino acid bromination
namespace: biological_process
def: "The addition of one or more bromine atoms to an amino acid residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018079 ! protein amino acid halogenation

[Term]
id: GO:0018074
name: peptidyl-histidine bromination
namespace: biological_process
def: "The posttranslational bromination of peptidyl-histidine to form peptidyl-L-bromohistidine; the position of the bromine substitution is unknown." [RESID:AA0173]
subset: gosubset_prok
xref: RESID:AA0173
is_a: GO:0018073 ! protein amino acid bromination
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0018075
name: peptidyl-phenylalanine bromination
namespace: biological_process
def: "The posttranslational bromination of phenylalanine." [RESID:AA0174, RESID:AA0175, RESID:AA0176]
subset: gosubset_prok
xref: RESID:AA0174
xref: RESID:AA0175
xref: RESID:AA0176
is_a: GO:0018073 ! protein amino acid bromination
is_a: GO:0018207 ! peptidyl-phenylalanine modification

[Term]
id: GO:0018076
name: N-terminal peptidyl-lysine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal lysine of proteins." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018394 ! peptidyl-lysine acetylation

[Term]
id: GO:0018077
name: protein amino acid iodination
namespace: biological_process
def: "The addition of one or more iodine atoms to an amino acid residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018079 ! protein amino acid halogenation

[Term]
id: GO:0018078
name: peptidyl-thyronine iodination
namespace: biological_process
def: "The posttranslational iodination of peptidyl-thyronine, formed from tyrosine." [RESID:AA0177, RESID:AA0178]
subset: gosubset_prok
xref: RESID:AA0177
xref: RESID:AA0178
is_a: GO:0018077 ! protein amino acid iodination
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018079
name: protein amino acid halogenation
namespace: biological_process
def: "The addition of a halogen to a protein amino acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification
is_a: GO:0070276 ! halogen metabolic process

[Term]
id: GO:0018080
name: peptidyl-tryptophan bromination
namespace: biological_process
def: "The posttranslational bromination of peptidyl-tryptophan, to form peptidyl-L-6'-bromotryptophan." [RESID:AA0179]
subset: gosubset_prok
xref: RESID:AA0179
is_a: GO:0018073 ! protein amino acid bromination
is_a: GO:0018211 ! peptidyl-tryptophan modification

[Term]
id: GO:0018081
name: peptide cross-linking via lanthionine or 3-methyl-lanthionine
namespace: biological_process
def: "The posttranslational synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process." [ISBN:0198547684, RESID:AA0110, RESID:AA0111, RESID:AA0112]
subset: gosubset_prok
synonym: "peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine" EXACT []
synonym: "peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine" EXACT []
xref: RESID:AA0110
xref: RESID:AA0111
xref: RESID:AA0112
is_a: GO:0018149 ! peptide cross-linking

[Term]
id: GO:0018082
name: peptidyl-(Z)-dehydrobutyrine biosynthetic process from peptidyl-threonine
namespace: biological_process
def: "The formation of (Z)-dehydrobutyrine by the posttranslational dehydration of peptidyl-threonine." [RESID:AA0182]
subset: gosubset_prok
synonym: "peptidyl-(Z)-dehydrobutyrine anabolism from peptidyl-threonine" EXACT []
synonym: "peptidyl-(Z)-dehydrobutyrine formation from peptidyl-threonine" EXACT []
synonym: "peptidyl-(Z)-dehydrobutyrine synthesis from peptidyl-threonine" EXACT []
xref: RESID:AA0182
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018083
name: peptidyl-L-3-oxoalanine biosynthetic process from peptidyl-cysteine or peptidyl-serine
namespace: biological_process
def: "The posttranslational modification of peptidyl-cysteine or peptidyl-serine to peptidyl-L-3-oxoalanine; characteristic of the active sites of arylsulfatases." [RESID:AA0185]
subset: gosubset_prok
synonym: "peptidyl-L-3-oxoalanine anabolism from peptidyl-cysteine or peptidyl-serine" EXACT []
synonym: "peptidyl-L-3-oxoalanine formation from peptidyl-cysteine or peptidyl-serine" EXACT []
synonym: "peptidyl-L-3-oxoalanine synthesis from peptidyl-cysteine or peptidyl-serine" EXACT []
xref: RESID:AA0185
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018084
name: peptidyl-lactic acid biosynthetic process from peptidyl-serine
namespace: biological_process
def: "The modification of N-terminal peptidyl-serine to lactic acid." [RESID:AA0186]
subset: gosubset_prok
synonym: "peptidyl-lactic acid anabolism from peptidyl-serine" EXACT []
synonym: "peptidyl-lactic acid formation from peptidyl-serine" EXACT []
synonym: "peptidyl-lactic acid synthesis from peptidyl-serine" EXACT []
xref: RESID:AA0186
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018085
name: peptidyl-L-amino acid racemization
namespace: biological_process
def: "The process of conversion of a L-amino acid into its enantiomer, the corresponding D-amino acid." [GOC:ma]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification
is_a: GO:0018366 ! chiral amino acid racemization

[Term]
id: GO:0018086
name: alanine racemization
namespace: biological_process
alt_id: GO:0018368
def: "OBSOLETE (was not defined before being made obsolete)." [RESID:AA0191]
comment: This term was made obsolete because it was replaced with more appropriate terms.
is_obsolete: true
consider: GO:0019122

[Term]
id: GO:0018091
name: peptidyl-asparagine racemization
namespace: biological_process
alt_id: GO:0018373
alt_id: GO:0019127
def: "The racemization of peptidyl-asparagine." [RESID:AA0196]
subset: gosubset_prok
xref: RESID:AA0196
is_a: GO:0018085 ! peptidyl-L-amino acid racemization
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0018094
name: protein polyglycylation
namespace: biological_process
def: "The posttranslational addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid." [RESID:AA0201]
subset: gosubset_prok
xref: RESID:AA0201
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018095
name: protein polyglutamylation
namespace: biological_process
def: "The posttranslational addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid." [RESID:AA0202]
subset: gosubset_prok
xref: RESID:AA0202
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018096
name: peptide cross-linking via S-(2-aminovinyl)-D-cysteine
namespace: biological_process
def: "The posttranslational synthesis of (S,Z)-S-(2-aminovinyl)cysteine forming an intra-polypeptide cross-link between serine and cysteine." [RESID:AA0204]
subset: gosubset_prok
xref: RESID:AA0204
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018097
name: protein-chromophore linkage via peptidyl-S-4-hydroxycinnamyl-L-cysteine
namespace: biological_process
def: "The synthesis of the chromophore S-4-hydroxycinnamyl-L-cysteine." [RESID:AA0207]
subset: gosubset_prok
synonym: "protein amino acid cinnamylation" BROAD []
xref: RESID:AA0207
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0018101
name: peptidyl-citrulline biosynthetic process from peptidyl-arginine
namespace: biological_process
def: "The hydrolysis of peptidyl-arginine to form peptidyl-citrulline." [RESID:AA0214]
subset: gosubset_prok
synonym: "peptidyl-citrulline anabolism from peptidyl-arginine" EXACT []
synonym: "peptidyl-citrulline formation from peptidyl-arginine" EXACT []
synonym: "peptidyl-citrulline synthesis from peptidyl-arginine" EXACT []
xref: RESID:AA0214
is_a: GO:0018195 ! peptidyl-arginine modification
is_a: GO:0019240 ! citrulline biosynthetic process

[Term]
id: GO:0018102
name: peptidyl-arginine hydroxylation to peptidyl-4-hydroxy-L-arginine
namespace: biological_process
def: "The hydroxylation of peptidyl-arginine to form peptidyl-4-hydroxy-L-arginine." [RESID:AA0215]
subset: gosubset_prok
xref: RESID:AA0215
is_a: GO:0018126 ! protein amino acid hydroxylation
is_a: GO:0030961 ! peptidyl-arginine hydroxylation

[Term]
id: GO:0018103
name: protein amino acid C-linked glycosylation
namespace: biological_process
def: "A protein amino acid glycosylation process in which a sugar unit is added to a protein via a C atom." [PMID:7947762, RESID:AA0217]
subset: gosubset_prok
xref: RESID:AA0217
is_a: GO:0006486 ! protein amino acid glycosylation

[Term]
id: GO:0018104
name: peptidoglycan-protein cross-linking
namespace: biological_process
def: "The process of covalently linking peptidoglycan (murein) to proteins." [GOC:jsg]
subset: gosubset_prok
is_a: GO:0009252 ! peptidoglycan biosynthetic process

[Term]
id: GO:0018105
name: peptidyl-serine phosphorylation
namespace: biological_process
def: "The posttranslational phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037]
subset: gosubset_prok
xref: RESID:AA0037
is_a: GO:0006468 ! protein amino acid phosphorylation
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018106
name: peptidyl-histidine phosphorylation
namespace: biological_process
def: "The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0035, RESID:AA0036]
subset: gosubset_prok
xref: RESID:AA0035
xref: RESID:AA0036
is_a: GO:0006468 ! protein amino acid phosphorylation
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0018107
name: peptidyl-threonine phosphorylation
namespace: biological_process
def: "The posttranslational phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038]
subset: gosubset_prok
xref: RESID:AA0038
is_a: GO:0006468 ! protein amino acid phosphorylation
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018108
name: peptidyl-tyrosine phosphorylation
namespace: biological_process
def: "The posttranslational phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039]
subset: gosubset_prok
xref: RESID:AA0039
is_a: GO:0006468 ! protein amino acid phosphorylation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018109
name: peptidyl-arginine phosphorylation
namespace: biological_process
def: "The posttranslational phosphorylation of peptidyl-arginine to form omega-N-phospho-L-arginine." [RESID:AA0222]
subset: gosubset_prok
xref: RESID:AA0222
is_a: GO:0006468 ! protein amino acid phosphorylation
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0018110
name: histone arginine kinase activity
namespace: molecular_function
synonym: "histone-arginine kinase activity" EXACT []
xref: EC:2.7.3.-
is_a: GO:0004054 ! arginine kinase activity
is_a: GO:0035173 ! histone kinase activity

[Term]
id: GO:0018111
name: methionine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine = D-methionine." [EC:5.1.1.2]
xref: EC:5.1.1.2
xref: MetaCyc:METHIONINE-RACEMASE-RXN
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0018112
name: proline racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline = D-proline." [EC:5.1.1.4]
subset: gosubset_prok
xref: EC:5.1.1.4
xref: MetaCyc:PROLINE-RACEMASE-RXN
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0018113
name: lysine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine = D-lysine." [EC:5.1.1.5]
xref: EC:5.1.1.5
xref: MetaCyc:LYSINE-RACEMASE-RXN
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0018114
name: threonine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine = D-threonine." [EC:5.1.1.6]
xref: EC:5.1.1.6
xref: MetaCyc:THREONINE-RACEMASE-RXN
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0018115
name: peptidyl-S-diphytanylglycerol diether-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The co- or posttranslational modification of cysteine to form peptidyl-S-diphytanylglycerol diether-L-cysteine." [PMID:7797461, RESID:AA0223]
subset: gosubset_prok
synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0223
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018116
name: peptidyl-lysine adenylylation
namespace: biological_process
def: "The adenylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-adenosine)-L-lysine." [RESID:AA0227]
subset: gosubset_prok
synonym: "peptidyl-lysine adenylation" EXACT []
xref: RESID:AA0227
is_a: GO:0018117 ! protein amino acid adenylylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018117
name: protein amino acid adenylylation
namespace: biological_process
alt_id: GO:0018176
def: "The addition of phospho-adenosine to a protein amino acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein adenylation" EXACT []
is_a: GO:0018175 ! protein amino acid nucleotidylation

[Term]
id: GO:0018118
name: peptidyl-L-cysteine glutathione disulfide biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The posttranslational modification of peptidyl-cysteine by covalent addition of glutathione to form peptidyl-L-cysteine glutathione disulfide." [RESID:AA0229]
subset: gosubset_prok
synonym: "peptidyl-L-cysteine glutathione disulfide anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine glutathione disulfide formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine glutathione disulfide synthesis from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine glutathione disulphide biosynthesis from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine glutathione disulphide biosynthetic process from peptidyl-cysteine" EXACT []
xref: RESID:AA0229
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018119
name: peptidyl-cysteine S-nitrosylation
namespace: biological_process
def: "The posttranslational S-nitrosylation of peptidyl-cysteine to form peptidyl-S-nitrosyl-L-cysteine." [RESID:AA0230]
subset: gosubset_prok
xref: RESID:AA0230
is_a: GO:0017014 ! protein amino acid nitrosylation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018120
name: peptidyl-arginine ADP-ribosylation
namespace: biological_process
def: "The transfer, from NAD, of ADP-ribose to peptidyl-arginine to form omega-N-(ADP-ribosyl)-L-arginine." [RESID:AA0168]
subset: gosubset_prok
xref: RESID:AA0168
is_a: GO:0006471 ! protein amino acid ADP-ribosylation
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0018121
name: NAD(P)-asparagine ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine." [EC:2.4.2.-]
xref: EC:2.4.2.-
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0018122
name: peptidyl-asparagine ADP-ribosylation
namespace: biological_process
def: "The transfer, from NAD, of ADP-ribose to peptidyl-asparagine to form peptidyl-N4-(ADP-ribosyl)-L-asparagine." [RESID:AA0231]
subset: gosubset_prok
xref: RESID:AA0231
is_a: GO:0006471 ! protein amino acid ADP-ribosylation
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0018123
name: peptidyl-cysteine ADP-ribosylation
namespace: biological_process
def: "The transfer, from NAD, of ADP-ribose to peptidyl-cysteine to form peptidyl-S-(ADP-ribosyl)-L-cysteine." [RESID:AA0169]
subset: gosubset_prok
xref: RESID:AA0169
is_a: GO:0006471 ! protein amino acid ADP-ribosylation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018124
name: peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone
namespace: biological_process
def: "The cross-linking of the epsilon-amino group of a peptidyl-lysine with peptidyl-topaquinone, a modified tyrosine residue." [RESID:AA0233]
subset: gosubset_prok
xref: RESID:AA0233
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018125
name: peptidyl-cysteine methylation
namespace: biological_process
def: "The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine." [RESID:AA0234]
subset: gosubset_prok
xref: RESID:AA0234
is_a: GO:0006479 ! protein amino acid methylation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018126
name: protein amino acid hydroxylation
namespace: biological_process
def: "The addition of a hydroxy group to a protein amino acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018127
name: NAD(P)-serine ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine." [EC:2.4.2.-]
xref: EC:2.4.2.-
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0018128
name: peptidyl-serine cyclase activity
namespace: molecular_function
xref: EC:4.2.1.-
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018129
name: peptidyl-oxazoline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reduction of a peptide-linked oxazoline to oxazole." [GOC:mah, PMID:19058272]
xref: EC:1.3.-.-
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018130
name: heterocycle biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]
subset: gosubset_prok
synonym: "heterocycle anabolism" EXACT []
synonym: "heterocycle biosynthesis" EXACT []
synonym: "heterocycle formation" EXACT []
synonym: "heterocycle synthesis" EXACT []
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0018131
name: oxazole or thiazole biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "oxazole or thiazole anabolism" EXACT []
synonym: "oxazole or thiazole biosynthesis" EXACT []
synonym: "oxazole or thiazole formation" EXACT []
synonym: "oxazole or thiazole synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0046484 ! oxazole or thiazole metabolic process

[Term]
id: GO:0018132
name: peptide cross-linking via L-cysteine oxazolecarboxylic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [PMID:8895467, RESID:AA0238]
subset: gosubset_prok
xref: RESID:AA0238
is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018133
name: peptide cross-linking via L-cysteine oxazolinecarboxylic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue." [RESID:AA0239]
subset: gosubset_prok
xref: RESID:AA0239
is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018134
name: peptide cross-linking via glycine oxazolecarboxylic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0240]
subset: gosubset_prok
xref: RESID:AA0240
is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018135
name: peptidyl-cysteine cyclase activity
namespace: molecular_function
xref: EC:4.2.1.-
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018136
name: peptidyl-thiazoline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reduction of a peptide-linked thiazoline to thiazole." [GOC:mah, PMID:19058272]
xref: EC:1.3.-.-
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018137
name: peptide cross-linking via glycine thiazolecarboxylic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl glycine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0241]
subset: gosubset_prok
xref: RESID:AA0241
is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018138
name: peptide cross-linking via L-serine thiazolecarboxylic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0242]
subset: gosubset_prok
xref: RESID:AA0242
is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018139
name: peptide cross-linking via L-phenylalanine thiazolecarboxylic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl phenylalanine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0243]
subset: gosubset_prok
xref: RESID:AA0243
is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018207 ! peptidyl-phenylalanine modification

[Term]
id: GO:0018140
name: peptide cross-linking via L-cysteine thiazolecarboxylic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl cysteine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0244]
subset: gosubset_prok
xref: RESID:AA0244
is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018141
name: peptide cross-linking via L-lysine thiazolecarboxylic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl lysine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0245]
subset: gosubset_prok
xref: RESID:AA0245
is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018142
name: protein-DNA covalent cross-linking
namespace: biological_process
def: "The formation of a covalent cross-link between DNA and a protein." [GOC:ma]
subset: gosubset_prok
synonym: "DNA-protein covalent cross-linking" EXACT [GOC:mah]
is_a: GO:0018143 ! nucleic acid-protein covalent cross-linking

[Term]
id: GO:0018143
name: nucleic acid-protein covalent cross-linking
namespace: biological_process
def: "The formation of a covalent cross-link between a nucleic acid and a protein." [GOC:ma]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018144
name: RNA-protein covalent cross-linking
namespace: biological_process
def: "The formation of a covalent cross-link between RNA and a protein." [GOC:ma]
subset: gosubset_prok
is_a: GO:0018143 ! nucleic acid-protein covalent cross-linking

[Term]
id: GO:0018145
name: protein-DNA covalent cross-linking via peptidyl-serine
namespace: biological_process
def: "The formation of a covalent cross-link between DNA and a peptidyl-serine residue by the formation of O-(phospho-5'-DNA)-L-serine." [RESID:AA0246]
subset: gosubset_prok
synonym: "DNA-protein covalent cross-linking via peptidyl-serine" EXACT [GOC:mah]
xref: RESID:AA0246
is_a: GO:0018142 ! protein-DNA covalent cross-linking
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018146
name: keratan sulfate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [ISBN:0198547684, RESID:AA0247]
subset: gosubset_prok
synonym: "keratan sulfate anabolism" EXACT []
synonym: "keratan sulfate biosynthesis" EXACT []
synonym: "keratan sulfate formation" EXACT []
synonym: "keratan sulfate synthesis" EXACT []
synonym: "keratan sulphate biosynthesis" EXACT []
synonym: "keratan sulphate biosynthetic process" EXACT []
xref: RESID:AA0247
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0042339 ! keratan sulfate metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0018147
name: molybdenum incorporation via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)
namespace: biological_process
def: "The incorporation of molybdenum into a protein via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)." [RESID:AA0248]
subset: gosubset_prok
xref: RESID:AA0248
is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex
is_a: GO:0050844 ! peptidyl-selenocysteine modification

[Term]
id: GO:0018148
name: RNA-protein covalent cross-linking via peptidyl-tyrosine
namespace: biological_process
def: "The formation of a covalent cross-link between RNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-RNA)-L-tyrosine." [RESID:AA0249]
subset: gosubset_prok
xref: RESID:AA0249
is_a: GO:0018144 ! RNA-protein covalent cross-linking
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018149
name: peptide cross-linking
namespace: biological_process
def: "The formation of a covalent cross-link between or within protein chains." [GOC:jsg]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018150
name: peptide cross-linking via 3-(3'-L-histidyl)-L-tyrosine
namespace: biological_process
def: "The posttranslation modification of peptidyl-histidine and peptidyl-tyrosine to form a 3-(3'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0250]
subset: gosubset_prok
xref: RESID:AA0250
is_a: GO:0018151 ! peptide cross-linking via L-histidyl-L-tyrosine

[Term]
id: GO:0018151
name: peptide cross-linking via L-histidyl-L-tyrosine
namespace: biological_process
def: "The posttranslation modification of peptidyl-histidine and peptidyl-tyrosine to form a protein cross-link." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018152
name: peptide cross-linking via 3'-(1'-L-histidyl)-L-tyrosine
namespace: biological_process
def: "The posttranslation modification of peptidyl-histidine and peptidyl-tyrosine to form a 3'-(1'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0270]
subset: gosubset_prok
xref: RESID:AA0270
is_a: GO:0018151 ! peptide cross-linking via L-histidyl-L-tyrosine

[Term]
id: GO:0018153
name: isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
namespace: biological_process
def: "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glutamine to produce N6-(L-isoglutamyl)-L-lysine." [RESID:AA0124]
subset: gosubset_prok
xref: RESID:AA0124
is_a: GO:0018199 ! peptidyl-glutamine modification
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018262 ! isopeptide cross-linking

[Term]
id: GO:0018154
name: peptide cross-linking via (2R,6R)-lanthionine
namespace: biological_process
def: "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of (2R,6R)-lanthionine (L-lanthionine)." [RESID:AA0110]
subset: gosubset_prok
xref: RESID:AA0110
is_a: GO:0018081 ! peptide cross-linking via lanthionine or 3-methyl-lanthionine
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018155
name: peptide cross-linking via sn-(2S,6R)-lanthionine
namespace: biological_process
def: "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of sn-(2S,6R)-lanthionine (meso-lanthione)." [RESID:AA0111]
subset: gosubset_prok
xref: RESID:AA0111
is_a: GO:0018081 ! peptide cross-linking via lanthionine or 3-methyl-lanthionine
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018156
name: peptide cross-linking via (2S,3S,6R)-3-methyl-lanthionine
namespace: biological_process
def: "The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,6R)-3-methyl-lanthionine (3-methyl-L-lanthionine)." [RESID:AA0112]
subset: gosubset_prok
xref: RESID:AA0112
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018157
name: peptide cross-linking via an oxazole or thiazole
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine, or peptidyl cysteine-peptidyl glycine cross-link by the condensation of the serine hydroxyl or cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [GOC:jsg]
subset: gosubset_prok
is_a: GO:0018131 ! oxazole or thiazole biosynthetic process
is_a: GO:0018149 ! peptide cross-linking

[Term]
id: GO:0018158
name: protein amino acid oxidation
namespace: biological_process
def: "The modification of a protein amino acid by oxidation." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018159
name: peptidyl-methionine oxidation
namespace: biological_process
def: "The oxidation of peptidyl-L-methionine to peptidyl-L-methionine sulfone." [RESID:AA0251]
subset: gosubset_prok
xref: RESID:AA0251
is_a: GO:0018158 ! protein amino acid oxidation
is_a: GO:0018206 ! peptidyl-methionine modification

[Term]
id: GO:0018160
name: peptidyl-pyrromethane cofactor linkage
namespace: biological_process
alt_id: GO:0018354
alt_id: GO:0033035
def: "The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine." [ChEBI:30410, RESID:AA0252]
subset: gosubset_prok
synonym: "dipyrromethane cofactor binding" RELATED [GOC:jsg]
synonym: "peptidyl-pyrromethane cofactor linkage via dipyrrolylmethanemethyl-L-cysteine" EXACT [GOC:jsg]
xref: RESID:AA0252
is_a: GO:0018065 ! protein-cofactor linkage
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018161
name: dipyrrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group." [http://www.chem.qmw.ac.uk/iupac/class/tetpy.html#03]
subset: gosubset_prok
synonym: "dipyrrin anabolism" EXACT []
synonym: "dipyrrin biosynthesis" EXACT []
synonym: "dipyrrin formation" EXACT []
synonym: "dipyrrin synthesis" EXACT []
synonym: "dipyrromethane biosynthesis" EXACT []
synonym: "dipyrromethane biosynthetic process" EXACT []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0046453 ! dipyrrin metabolic process

[Term]
id: GO:0018162
name: peptide cross-linking via S-(2-aminovinyl)-3-methyl-D-cysteine
namespace: biological_process
def: "The formation of a cross-link between peptidyl-cysteine and peptidyl-threonine via the formation of S-(2-aminovinyl)-3-methyl-D-cysteine." [RESID:AA0253]
subset: gosubset_prok
xref: RESID:AA0253
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018163
name: protein-DNA covalent cross-linking via the 5'-end to peptidyl-tyrosine
namespace: biological_process
def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-DNA)-L-tyrosine." [RESID:AA0254]
subset: gosubset_prok
synonym: "DNA-protein covalent cross-linking via the 5' end to peptidyl-tyrosine" EXACT [GOC:mah]
xref: RESID:AA0254
is_a: GO:0045327 ! protein-DNA covalent cross-linking via peptidyl-tyrosine

[Term]
id: GO:0018164
name: protein-DNA covalent cross-linking via peptidyl-threonine
namespace: biological_process
def: "The formation of a covalent cross-link between DNA and a peptidyl-threonine residue by the formation of O-(phospho-5'-DNA)-L-threonine." [RESID:AA0255]
subset: gosubset_prok
synonym: "DNA-protein covalent cross-linking via peptidyl-threonine" EXACT [GOC:mah]
xref: RESID:AA0255
is_a: GO:0018142 ! protein-DNA covalent cross-linking
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018165
name: peptidyl-tyrosine uridylylation
namespace: biological_process
def: "The uridylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-uridine)-L-tyrosine, found in glutamine synthetase." [RESID:AA0256]
subset: gosubset_prok
xref: RESID:AA0256
is_a: GO:0018177 ! protein amino acid uridylylation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018166
name: C-terminal protein-tyrosinylation
namespace: biological_process
def: "The ATP-dependent posttranslational addition of a tyrosine residue to the C-terminus of a protein; typically the addition of tyrosine to the C-terminus of detyrosinated alpha-tubulin by the enzyme tubulin-tyrosine ligase." [RESID:AA0257]
comment: See also the molecular function term 'tubulin-tyrosine ligase activity ; GO:0004835'.
subset: gosubset_prok
xref: RESID:AA0257
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0018322 ! protein amino acid tyrosinylation
is_a: GO:0018410 ! peptide or protein carboxyl-terminal blocking

[Term]
id: GO:0018167
name: protein-phycoerythrobilin linkage via phycoerythrobilin-bis-L-cysteine
namespace: biological_process
def: "The linkage of the chromophore phycoerythrobilin to phycoerythrin via phycoerythrobilin-bis-L-cysteine." [RESID:AA0259]
subset: gosubset_prok
xref: RESID:AA0259
is_a: GO:0017011 ! protein-phycoerythrobilin linkage
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018168
name: protein-phycoerythrobilin linkage via S-phycoerythrobilin-L-cysteine
namespace: biological_process
def: "The linkage of the chromophore phycoerythrobilin to phycoerythrocyanin via S-phycoerythrobilin-L-cysteine." [RESID:AA0132]
subset: gosubset_prok
xref: RESID:AA0132
is_a: GO:0017011 ! protein-phycoerythrobilin linkage
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018169
name: ribosomal S6-glutamic acid ligase activity
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6." [GOC:mah, PMID:2570347]
xref: EC:6.3.2.-
is_a: GO:0070739 ! protein-glutamic acid ligase activity

[Term]
id: GO:0018170
name: C-terminal peptidyl-polyglutamic acid amidation
namespace: biological_process
def: "The formation of a C-terminal peptidyl-polyglutamic acid to form a peptidyl-N-L-glutamyl-poly-L-glutamic acid C-terminus." [RESID:AA0261]
subset: gosubset_prok
xref: RESID:AA0261
is_a: GO:0018040 ! C-terminal peptidyl-glutamic acid amidation
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018171
name: peptidyl-cysteine oxidation
namespace: biological_process
def: "The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid." [PMID:9586994, RESID:AA0205, RESID:AA0262]
subset: gosubset_prok
xref: RESID:AA0205
xref: RESID:AA0262
is_a: GO:0018158 ! protein amino acid oxidation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018172
name: peptidyl-L-3',4',5'-trihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine
namespace: biological_process
def: "The, presumably, posttranslational modification of protein tyrosine to peptidyl-L-3',4',5'-dihydroxyphenylalanine." [RESID:AA0263]
subset: gosubset_prok
synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine anabolism from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine formation from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine synthesis from peptidyl-tyrosine" EXACT []
xref: RESID:AA0263
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0018336 ! peptidyl-tyrosine hydroxylation

[Term]
id: GO:0018173
name: peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptidyl-1-thioglycine from other compounds, including peptidyl-glycine." [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265]
subset: gosubset_prok
synonym: "peptidyl-1-thioglycine anabolism from peptidyl-glycine" EXACT []
synonym: "peptidyl-1-thioglycine formation from peptidyl-glycine" EXACT []
synonym: "peptidyl-1-thioglycine synthesis from peptidyl-glycine" EXACT []
xref: RESID:AA0265
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0044249 ! cellular biosynthetic process
relationship: part_of GO:0015011 ! nickel-tetrapyrrole coenzyme metabolic process

[Term]
id: GO:0018174
name: protein-heme P460 linkage
namespace: biological_process
def: "The linkage of protein to heme P460." [RESID:AA0266, RESID:AA0271]
subset: gosubset_prok
synonym: "protein-haem P460 linkage" EXACT []
xref: RESID:AA0266
xref: RESID:AA0271
is_a: GO:0017003 ! protein-heme linkage
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0018175
name: protein amino acid nucleotidylation
namespace: biological_process
def: "The addition of a nucleotide to a protein amino acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018177
name: protein amino acid uridylylation
namespace: biological_process
def: "The addition of phospho-uridine to a protein amino acid." [GOC:jsg]
subset: gosubset_prok
is_a: GO:0018175 ! protein amino acid nucleotidylation

[Term]
id: GO:0018178
name: peptidyl-threonine adenylylation
namespace: biological_process
def: "The adenylylation of peptidyl-threonine to form peptidyl-O-(phospho-5'-adenosine)-L-threonine." [RESID:AA0267]
subset: gosubset_prok
synonym: "peptidyl-threonine adenylation" EXACT []
xref: RESID:AA0267
is_a: GO:0018117 ! protein amino acid adenylylation
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018179
name: peptidyl-cysteine desulfurization
namespace: biological_process
def: "The posttranslational desulfurization of peptidyl-L-cysteine to yield L-alanine and elemental sulfur; peptidyl-L-cysteine persulfide is an intermediate." [RESID:AA0269]
subset: gosubset_prok
synonym: "peptidyl-cysteine desulphurization" EXACT []
xref: RESID:AA0269
is_a: GO:0018180 ! protein amino acid desulfurization

[Term]
id: GO:0018180
name: protein amino acid desulfurization
namespace: biological_process
def: "The removal of a sulfur group from a protein amino acid." [GOC:ai]
subset: gosubset_prok
synonym: "protein amino acid desulfurisation" EXACT []
synonym: "protein amino acid desulphurisation" EXACT []
synonym: "protein amino acid desulphurization" EXACT []
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018181
name: peptidyl-arginine C5-methylation
namespace: biological_process
def: "The methylation of peptidyl-arginine on the carbon 5 (C5) residue to form peptidyl-5-methyl-L-arginine." [GOC:bf, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0272]
subset: gosubset_prok
synonym: "peptidyl-arginine 5-methylation" EXACT []
xref: RESID:AA0272
is_a: GO:0035245 ! peptidyl-arginine C-methylation

[Term]
id: GO:0018182
name: protein-heme linkage via 3'-L-histidine
namespace: biological_process
def: "The covalent linkage of heme and a protein via 3'-L-histidine (otherwise known as pi-heme-histidine, pros-heme-histidine)." [RESID:AA0276]
subset: gosubset_prok
synonym: "protein-haem linkage via 3'-L-histidine" EXACT []
xref: RESID:AA0276
is_a: GO:0017003 ! protein-heme linkage
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0018183
name: enzyme active site formation via S-selenyl-L-cysteine
namespace: biological_process
def: "OBSOLETE. The transient selenylation of peptidyl-cysteine to form S-selenyl-L-cysteine." [RESID:AA0277]
comment: This term was made obsolete because this structure does not exist.
is_obsolete: true

[Term]
id: GO:0018184
name: protein amino acid polyamination
namespace: biological_process
def: "The modification of a protein amino acid by polyamination." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018185
name: poly-N-methyl-propylamination
namespace: biological_process
def: "The modification of peptidyl-lysine by the addition of an N6-propylamino and of propylmethylamino units, forming N6-(propylamino-poly(propylmethylamino)-propyldimethylamine)-L-lysine, typical of the silicate binding protein silaffin." [RESID:AA0278]
subset: gosubset_prok
xref: RESID:AA0278
is_a: GO:0018184 ! protein amino acid polyamination
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018186
name: peroxidase-heme linkage
namespace: biological_process
def: "The covalent linkage of heme to peroxidase." [RESID:AA0279, RESID:AA0280]
subset: gosubset_prok
synonym: "peroxidase-haem linkage" EXACT []
xref: RESID:AA0279
xref: RESID:AA0280
is_a: GO:0017003 ! protein-heme linkage
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0018187
name: molybdenum incorporation via L-cysteinyl molybdopterin guanine dinucleotide
namespace: biological_process
def: "The incorporation of molybdenum into a protein by L-cysteinyl molybdopterin guanine dinucleotide." [RESID:AA0281]
subset: gosubset_prok
xref: RESID:AA0281
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex

[Term]
id: GO:0018188
name: peptidyl-proline di-hydroxylation
namespace: biological_process
def: "The posttranslational modification of peptidyl-proline to form trans-2,3-cis-3,4-dihydroxy-L-proline." [RESID:AA0282]
subset: gosubset_prok
xref: RESID:AA0282
is_a: GO:0019511 ! peptidyl-proline hydroxylation

[Term]
id: GO:0018189
name: pyrroloquinoline quinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed." [PMID:7665488, RESID:AA0283]
subset: gosubset_prok
synonym: "coenzyme pyrroloquinoline-quinone biosynthesis" EXACT []
synonym: "coenzyme pyrroloquinoline-quinone biosynthetic process" EXACT []
synonym: "PQQ biosynthesis" EXACT []
synonym: "PQQ biosynthetic process" EXACT []
synonym: "pyrroloquinoline quinone anabolism" EXACT []
synonym: "pyrroloquinoline quinone biosynthesis" EXACT []
synonym: "pyrroloquinoline quinone formation" EXACT []
synonym: "pyrroloquinoline quinone synthesis" EXACT []
synonym: "pyrroloquinoline-quinone biosynthesis" EXACT []
synonym: "pyrroloquinoline-quinone biosynthetic process" EXACT []
xref: RESID:AA0283
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0045426 ! quinone cofactor biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0018190
name: protein amino acid octanoylation
namespace: biological_process
def: "The modification of a protein amino acid by formation of an ester or amide with octanoic acid." [GOC:jsg]
subset: gosubset_prok
is_a: GO:0006497 ! protein amino acid lipidation
is_a: GO:0043543 ! protein amino acid acylation

[Term]
id: GO:0018191
name: peptidyl-serine octanoylation
namespace: biological_process
def: "The posttranslational octanoylation of peptidyl-serine to form peptidyl-O3-octanoyl-L-serine, typical of the protein ghrelin." [PMID:10604470, RESID:AA0290]
subset: gosubset_prok
xref: RESID:AA0290
is_a: GO:0018190 ! protein amino acid octanoylation
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018192
name: enzyme active site formation via L-cysteine persulfide
namespace: biological_process
def: "The modification of peptidyl-cysteine to form peptidyl-L-cysteine persulfide. A persulfurated cysteine promotes active site reactivity in Azotobacter vinelandii Rhodanese." [PMID:11592406, RESID:AA0269]
subset: gosubset_prok
synonym: "enzyme active site formation via L-cysteine persulphide" EXACT []
xref: RESID:AA0269
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018193
name: peptidyl-amino acid modification
namespace: biological_process
def: "The alteration of an amino acid residue in a peptide." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006464 ! protein modification process

[Term]
id: GO:0018194
name: peptidyl-alanine modification
namespace: biological_process
def: "The modification of peptidyl-alanine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018195
name: peptidyl-arginine modification
namespace: biological_process
def: "The modification of peptidyl-arginine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018196
name: peptidyl-asparagine modification
namespace: biological_process
def: "The modification of peptidyl-asparagine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018197
name: peptidyl-aspartic acid modification
namespace: biological_process
def: "The modification of peptidyl-aspartic acid." [GOC:ma]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018198
name: peptidyl-cysteine modification
namespace: biological_process
def: "The modification of peptidyl-cysteine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018199
name: peptidyl-glutamine modification
namespace: biological_process
def: "The modification of peptidyl-glutamine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018200
name: peptidyl-glutamic acid modification
namespace: biological_process
def: "The modification of peptidyl-glutamic acid." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018201
name: peptidyl-glycine modification
namespace: biological_process
def: "The modification of peptidyl-glycine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018202
name: peptidyl-histidine modification
namespace: biological_process
def: "The modification of peptidyl-histidine." [GOC:ma]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018203
name: peptidyl-isoleucine modification
namespace: biological_process
def: "The modification of peptidyl-isoleucine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018204
name: peptidyl-leucine modification
namespace: biological_process
def: "The modification of peptidyl-leucine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018205
name: peptidyl-lysine modification
namespace: biological_process
def: "The modification of peptidyl-lysine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018206
name: peptidyl-methionine modification
namespace: biological_process
def: "The modification of peptidyl-methionine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018207
name: peptidyl-phenylalanine modification
namespace: biological_process
def: "The modification of peptidyl-phenylalanine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018208
name: peptidyl-proline modification
namespace: biological_process
def: "The modification of peptidyl-proline." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018209
name: peptidyl-serine modification
namespace: biological_process
def: "The modification of peptidyl-serine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018210
name: peptidyl-threonine modification
namespace: biological_process
def: "The modification of peptidyl-threonine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018211
name: peptidyl-tryptophan modification
namespace: biological_process
def: "The chemical alteration of a tryptophan residue in a peptide." [GOC:isa_complete]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018212
name: peptidyl-tyrosine modification
namespace: biological_process
def: "The modification of peptidyl-tyrosine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018213
name: peptidyl-valine modification
namespace: biological_process
def: "The modification of peptidyl-valine." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0018214
name: protein amino acid carboxylation
namespace: biological_process
def: "The addition of a carboxy group to a protein amino acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018215
name: protein amino acid phosphopantetheinylation
namespace: biological_process
def: "The modification of a protein amino acid by phosphopantetheinylation." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018216
name: peptidyl-arginine methylation
namespace: biological_process
alt_id: GO:0018017
def: "The addition of a methyl group to an arginine residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006479 ! protein amino acid methylation
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0018217
name: peptidyl-aspartic acid phosphorylation
namespace: biological_process
def: "The posttranslational phosphorylation of peptidyl-aspartic acid." [GOC:jl]
subset: gosubset_prok
is_a: GO:0006468 ! protein amino acid phosphorylation
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0018218
name: peptidyl-cysteine phosphorylation
namespace: biological_process
def: "The phosphorylation of peptidyl-cysteine to form peptidyl-S-phospho-L-cysteine." [RESID:AA0034]
subset: gosubset_prok
xref: RESID:AA0034
is_a: GO:0006468 ! protein amino acid phosphorylation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018219
name: peptidyl-cysteine S-acetylation
namespace: biological_process
def: "The acetylation of peptidyl-cysteine to form peptidyl-S-acetyl-L-cysteine." [RESID:AA0056]
subset: gosubset_prok
xref: RESID:AA0056
is_a: GO:0018533 ! peptidyl-cysteine acetylation

[Term]
id: GO:0018220
name: peptidyl-threonine palmitoylation
namespace: biological_process
def: "The palmitoylation of peptidyl-threonine to form peptidyl-O-palmitoyl-L-threonine." [RESID:AA0079]
subset: gosubset_prok
xref: RESID:AA0079
is_a: GO:0018210 ! peptidyl-threonine modification
is_a: GO:0018318 ! protein amino acid palmitoylation

[Term]
id: GO:0018221
name: peptidyl-serine palmitoylation
namespace: biological_process
def: "The palmitoylation of peptidyl-serine to form peptidyl-O-palmitoyl-L-threonine." [RESID:AA0080]
subset: gosubset_prok
xref: RESID:AA0080
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018318 ! protein amino acid palmitoylation

[Term]
id: GO:0018222
name: peptidyl-L-cysteine methyl disulfide biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The, presumably, posttranslational modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl disulfide." [RESID:AA0101]
subset: gosubset_prok
synonym: "peptidyl-L-cysteine methyl disulfide anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl disulfide formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl disulfide synthesis from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl disulphide biosynthesis from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl disulphide biosynthetic process from peptidyl-cysteine" EXACT []
xref: RESID:AA0101
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018226
name: peptidyl-S-farnesyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The posttranslational modification of peptidyl-cysteine to form peptidyl-S-farnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine; the residue may be found at the first position in the sequence motif C-X-X-(SAQCMT)* where the second and third positions are usually aliphatic." [RESID:AA0102]
subset: gosubset_prok
synonym: "peptidyl-S-farnesyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-farnesyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-farnesyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0102
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018347 ! protein amino acid farnesylation

[Term]
id: GO:0018227
name: peptidyl-S-12-hydroxyfarnesyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The posttranslational modification of peptidyl-cysteine to form S-12-hydroxyfarnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine." [RESID:AA0103]
subset: gosubset_prok
synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0103
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018347 ! protein amino acid farnesylation

[Term]
id: GO:0018228
name: peptidyl-S-geranylgeranyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The posttranslational modification of peptidyl-cysteine to form peptidyl-S-geranylgeranylcysteine; formation of S-geranylgeranyl-L-cysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CAAX motif and methyl esterification of the geranylgeranylated cysteine; methyl esterification but not cleavage occurs for the CXC motif. For the type II geranylgeranyltransferase the residue may be found at the first and final positions in the sequence motif C-X-C* or at the final position in the sequence motif C-C*. These motifs are necessary but not sufficient for modification." [RESID:AA0104]
subset: gosubset_prok
synonym: "peptidyl-S-geranylgeranyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-geranylgeranyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-geranylgeranyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0104
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018348 ! protein amino acid geranylgeranylation

[Term]
id: GO:0018229
name: peptidyl-L-cysteine methyl ester biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The posttranslational modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl ester." [RESID:AA0105]
subset: gosubset_prok
synonym: "peptidyl-L-cysteine methyl ester anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl ester formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-L-cysteine methyl ester synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0105
is_a: GO:0018351 ! peptidyl-cysteine esterification

[Term]
id: GO:0018230
name: peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The posttranslational modification of peptidyl-cysteine to form peptidyl-S-palmitoyl-L-cysteine; the palmitate group represents a mixture of saturated and unsaturated fatty acids." [RESID:AA0106]
subset: gosubset_prok
synonym: "peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0106
is_a: GO:0018231 ! peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
is_a: GO:0018318 ! protein amino acid palmitoylation

[Term]
id: GO:0018231
name: peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The co- or posttranslational modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids." [RESID:AA0107]
subset: gosubset_prok
synonym: "peptidyl-S-diacylglycerol-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-diacylglycerol-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-diacylglycerol-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0107
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018232
name: peptide cross-linking via S-(L-isoglutamyl)-L-cysteine
namespace: biological_process
def: "The posttranslation modification of peptidyl-glutamine and peptidyl-cysteine to form a S-(L-isoglutamyl)-L-cysteine protein cross-link." [RESID:AA0108]
subset: gosubset_prok
xref: RESID:AA0108
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018199 ! peptidyl-glutamine modification

[Term]
id: GO:0018233
name: peptide cross-linking via 2'-(S-L-cysteinyl)-L-histidine
namespace: biological_process
def: "The posttranslation modification of peptidyl-histidine and peptidyl-cysteine to form a 2'-(S-L-cysteinyl)-L-histidine protein cross-link." [RESID:AA0109]
subset: gosubset_prok
xref: RESID:AA0109
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0018234
name: peptide cross-linking via 3'-(S-L-cysteinyl)-L-tyrosine
namespace: biological_process
def: "The posttranslational thioether cross-linking of a cysteine residue to a tyrosine residue to form 3'-(S-L-cysteinyl)-L-tyrosine, found in galactose oxidase." [RESID:AA0113]
subset: gosubset_prok
xref: RESID:AA0113
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018235
name: peptidyl-lysine carboxylation
namespace: biological_process
def: "The posttranslational modification of peptidyl-lysine to form peptidyl-N6-carboxy-L-lysine." [RESID:AA0114]
subset: gosubset_prok
xref: RESID:AA0114
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018214 ! protein amino acid carboxylation

[Term]
id: GO:0018236
name: ribulose-bisphosphate carboxylase activase activity
namespace: molecular_function
xref: EC:6.3.-.-
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0018237
name: urease activase activity
namespace: molecular_function
xref: EC:6.3.-.-
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0018238
name: peptidyl-lysine carboxyethylation
namespace: biological_process
alt_id: GO:0018239
def: "The posttranslational modification of peptidyl-lysine to form peptidyl-N6-1-carboxyethyl-L-lysine." [RESID:AA0115]
subset: gosubset_prok
synonym: "protein amino acid carboxyethylation" EXACT []
xref: RESID:AA0115
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018240
name: protein amino acid S-linked glycosylation via cysteine
namespace: biological_process
def: "The posttranslational glycosylation of protein via the sulfur atom of peptidyl-cysteine, forming S-glycosyl-L-cysteine." [RESID:AA0152]
subset: gosubset_prok
xref: RESID:AA0152
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018280 ! protein amino acid S-linked glycosylation

[Term]
id: GO:0018241
name: protein amino acid O-linked glycosylation via hydroxylysine
namespace: biological_process
def: "The posttranslational glycosylation of protein via the O5 atom of peptidyl-hydroxylysine, forming O5-glycosyl-L-hydroxylysine; the most common form is galactosyl hydroxylysine." [RESID:AA0153]
subset: gosubset_prok
xref: RESID:AA0153
is_a: GO:0006493 ! protein amino acid O-linked glycosylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018242
name: protein amino acid O-linked glycosylation via serine
namespace: biological_process
def: "The posttranslational glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine." [RESID:AA0154]
subset: gosubset_prok
xref: RESID:AA0154
is_a: GO:0006493 ! protein amino acid O-linked glycosylation
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018243
name: protein amino acid O-linked glycosylation via threonine
namespace: biological_process
def: "The posttranslational glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine." [RESID:AA0155]
subset: gosubset_prok
xref: RESID:AA0155
is_a: GO:0006493 ! protein amino acid O-linked glycosylation
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018244
name: protein amino acid N-linked glycosylation via tryptophan
namespace: biological_process
def: "The posttranslational glycosylation of protein via peptidyl-tryptophan, 1'-glycosyl-L-tryptophan; it is uncertain whether this is an N-glycoside linkage (as indicated), and which particular hexose is involved." [RESID:AA0156]
subset: gosubset_prok
xref: RESID:AA0156
is_a: GO:0006487 ! protein amino acid N-linked glycosylation
is_a: GO:0018211 ! peptidyl-tryptophan modification

[Term]
id: GO:0018245
name: protein amino acid O-linked glycosylation via tyrosine
namespace: biological_process
def: "The posttranslational glycosylation of protein via the O4' atom of peptidyl-tyrosine, O4'-glycosyl-L-tyrosine; the carbohydrate is glucose, the origin for glycogen." [RESID:AA0157]
subset: gosubset_prok
xref: RESID:AA0157
is_a: GO:0006493 ! protein amino acid O-linked glycosylation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018246
name: protein-coenzyme A linkage
namespace: biological_process
def: "The formation of a linkage between a protein amino acid and coenzyme A." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018065 ! protein-cofactor linkage

[Term]
id: GO:0018247
name: protein-phosphoribosyl dephospho-coenzyme A linkage
namespace: biological_process
def: "The linkage of phosphoribosyl dephospho-coenzyme A to protein via peptidyl-serine, to form O-(phosphoribosyl dephospho-coenzyme A)-L-serine; it is uncertain whether the phosphoribosyl glycosidic attachment to the dephospho-coenzyme A is alpha or beta, and through the 2' or the 3' position." [RESID:AA0167]
subset: gosubset_prok
xref: RESID:AA0167
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018246 ! protein-coenzyme A linkage

[Term]
id: GO:0018248
name: enzyme active site formation via S-sulfo-L-cysteine
namespace: biological_process
def: "The transient sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine." [RESID:AA0171]
subset: gosubset_prok
synonym: "enzyme active site formation via S-sulpho-L-cysteine" EXACT []
xref: RESID:AA0171
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018249
name: protein amino acid dehydration
namespace: biological_process
def: "The removal of a water group from a protein amino acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018250
name: peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine
namespace: biological_process
def: "The formation of peptidyl-dehydroalanine from either peptidyl-tyrosine by phenyl transfer, or from peptidyl-serine, which is coupled with the formation of 5-imidazolinone by the two neighboring residues, produces an 4-methylidene-imidazole-5-one active site of some amino acid ammonia-lyases; the 4-methylidene-imidazole-5-one, is formed autocatalytically by cyclization and dehydration of the sequence ASG." [RESID:AA0181]
subset: gosubset_prok
synonym: "peptidyl-dehydroalanine anabolism from peptidyl-tyrosine or peptidyl-serine" EXACT []
synonym: "peptidyl-dehydroalanine formation from peptidyl-tyrosine or peptidyl-serine" EXACT []
synonym: "peptidyl-dehydroalanine synthesis from peptidyl-tyrosine or peptidyl-serine" EXACT []
xref: RESID:AA0181
is_a: GO:0018194 ! peptidyl-alanine modification
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0018249 ! protein amino acid dehydration
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0018251
name: peptidyl-tyrosine dehydrogenation
namespace: biological_process
def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-dehydrotyrosine coupled with cyclization of neighboring residues." [RESID:AA0183]
comment: See also the biological process terms 'peptide cross-linking via L-seryl-5-imidazolinone glycine ; GO:0018252' and 'peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine ; GO:0019729'.
subset: gosubset_prok
xref: RESID:AA0183
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0018249 ! protein amino acid dehydration

[Term]
id: GO:0018252
name: peptide cross-linking via L-seryl-5-imidazolinone glycine
namespace: biological_process
def: "The formation of the green fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a serine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0184]
comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'.
synonym: "biosynthesis of protein-protein cross-link via L-seryl-5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via L-seryl-5-imidazolinone glycine" EXACT []
xref: RESID:AA0184
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0018253
name: peptide cross-linking via 5-imidazolinone glycine
namespace: biological_process
def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue n, an alanine, serine or cysteine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with an oxidation of residue n+1 to form an active aldehyde." [RESID:AA0184, RESID:AA0187, RESID:AA0188]
subset: gosubset_prok
synonym: "biosynthesis of protein-protein cross-link via 5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via 5-imidazolinone glycine" EXACT []
xref: RESID:AA0184
xref: RESID:AA0187
xref: RESID:AA0188
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018254
name: peptidyl-tyrosine adenylylation
namespace: biological_process
def: "The posttranslational adenylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-adenosine)-L-tyrosine." [RESID:AA0203]
subset: gosubset_prok
synonym: "peptidyl-tyrosine adenylation" EXACT []
xref: RESID:AA0203
is_a: GO:0018117 ! protein amino acid adenylylation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018255
name: peptide cross-linking via S-glycyl-L-cysteine
namespace: biological_process
def: "The formation of S-(peptidyl-glycyl)-peptidyl-cysteine cross-links by the formation of a thiolester between cysteine and the carboxy-terminal glycine of ubiquitin and other proteins." [RESID:AA0206]
subset: gosubset_prok
xref: RESID:AA0206
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018256
name: protein amino acid formylation
namespace: biological_process
def: "The addition of a formyl group to a protein amino acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043543 ! protein amino acid acylation

[Term]
id: GO:0018257
name: peptidyl-lysine formylation
namespace: biological_process
def: "The modification of peptidyl-lysine to form peptidyl-N6-formyl-L-lysine." [RESID:AA0211]
subset: gosubset_prok
xref: RESID:AA0211
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018256 ! protein amino acid formylation

[Term]
id: GO:0018258
name: protein amino acid O-linked glycosylation via hydroxyproline
namespace: biological_process
def: "The posttranslational glycosylation of proteins via 04 atom of hydroxyproline to form O4-glycosyl-L-hydroxyproline; the most common form is arabinofuranosyl-4-proline." [RESID:AA0212]
subset: gosubset_prok
xref: RESID:AA0212
is_a: GO:0006493 ! protein amino acid O-linked glycosylation
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0018259
name: RNA-protein covalent cross-linking via peptidyl-serine
namespace: biological_process
def: "The formation of a covalent cross-link between RNA and a peptidyl-serine residue by the formation of O-(phospho-5'-5NA)-L-serine." [RESID:AA0213]
subset: gosubset_prok
xref: RESID:AA0213
is_a: GO:0018144 ! RNA-protein covalent cross-linking
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018260
name: protein amino acid guanylylation
namespace: biological_process
def: "The addition of phospho-guanosine to a protein amino acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018175 ! protein amino acid nucleotidylation

[Term]
id: GO:0018261
name: peptidyl-lysine guanylylation
namespace: biological_process
def: "The posttranslational guanylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-guanosine)-L-lysine." [RESID:AA0228]
subset: gosubset_prok
xref: RESID:AA0228
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018260 ! protein amino acid guanylylation

[Term]
id: GO:0018262
name: isopeptide cross-linking
namespace: biological_process
def: "The formation of a covalent cross-link between or within peptide chains, where either the amino group or the carboxyl group, or both, are not attached to the alpha carbon." [GOC:jsg]
subset: gosubset_prok
is_a: GO:0018149 ! peptide cross-linking

[Term]
id: GO:0018263
name: isopeptide cross-linking via N-(L-isoaspartyl)-L-cysteine
namespace: biological_process
def: "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-cysteine to produce N-(L-isoaspartyl)-L-cysteine." [RESID:AA0216]
subset: gosubset_prok
xref: RESID:AA0216
is_a: GO:0018196 ! peptidyl-asparagine modification
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018262 ! isopeptide cross-linking

[Term]
id: GO:0018264
name: isopeptide cross-linking via N-(L-isoaspartyl)-glycine
namespace: biological_process
def: "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-glycine to produce N-(L-isoaspartyl)-glycine." [RESID:AA0126]
subset: gosubset_prok
xref: RESID:AA0126
is_a: GO:0018196 ! peptidyl-asparagine modification
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0018262 ! isopeptide cross-linking

[Term]
id: GO:0018265
name: GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-asparagine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a asparaginyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0158]
subset: gosubset_prok
synonym: "GPI anchor anabolism via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor formation via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor synthesis via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT []
xref: RESID:AA0158
is_a: GO:0006506 ! GPI anchor biosynthetic process
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0018266
name: GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-aspartic acid ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a aspartyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0159]
subset: gosubset_prok
synonym: "GPI anchor anabolism via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor formation via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor synthesis via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT []
xref: RESID:AA0159
is_a: GO:0006506 ! GPI anchor biosynthetic process
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0018267
name: GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-cysteine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a cysteinyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0160]
subset: gosubset_prok
synonym: "GPI anchor anabolism via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor formation via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor synthesis via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT []
xref: RESID:AA0160
is_a: GO:0006506 ! GPI anchor biosynthetic process
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018268
name: GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0161]
subset: gosubset_prok
synonym: "GPI anchor anabolism via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor formation via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor synthesis via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT []
xref: RESID:AA0161
is_a: GO:0006506 ! GPI anchor biosynthetic process
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0018269
name: GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0162]
subset: gosubset_prok
synonym: "GPI anchor anabolism via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor formation via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor synthesis via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT []
xref: RESID:AA0162
is_a: GO:0006506 ! GPI anchor biosynthetic process
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018270
name: GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-alanine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of an alanyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0163]
subset: gosubset_prok
synonym: "GPI anchor anabolism via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor formation via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor synthesis via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT []
xref: RESID:AA0163
is_a: GO:0006506 ! GPI anchor biosynthetic process
is_a: GO:0018194 ! peptidyl-alanine modification

[Term]
id: GO:0018271
name: biotin-protein ligase activity
namespace: molecular_function
alt_id: GO:0000106
def: "Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein." [GOC:mah]
subset: gosubset_prok
synonym: "biotin-apoprotein ligase activity" EXACT []
xref: EC:6.3.4.-
xref: MetaCyc:BIOTINLIG-RXN
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0018272
name: protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
namespace: biological_process
def: "The posttranslation modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine." [RESID:AA0119]
subset: gosubset_prok
xref: RESID:AA0119
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018352 ! protein-pyridoxal-5-phosphate linkage

[Term]
id: GO:0018273
name: protein-chromophore linkage via peptidyl-N6-retinal-L-lysine
namespace: biological_process
def: "The posttranslation modification of peptidyl-lysine to form N6-retinal-L-lysine." [RESID:AA0120]
subset: gosubset_prok
xref: RESID:AA0120
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0018274
name: peptide cross-linking via L-lysinoalanine
namespace: biological_process
def: "The posttranslational modification of peptidyl-lysine and peptidyl-serine to form a (2Xi,9S)-L-lysinoalanine cross-link." [RESID:AA0123]
subset: gosubset_prok
xref: RESID:AA0123
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018275
name: N-terminal peptidyl-cysteine acetylation
namespace: biological_process
alt_id: GO:0017191
def: "The acetylation of the N-terminal cysteine of proteins to form the derivative N-acetyl-L-cysteine." [RESID:AA0043]
subset: gosubset_prok
synonym: "peptidyl-cysteine N-acetylation" EXACT []
xref: RESID:AA0043
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018533 ! peptidyl-cysteine acetylation

[Term]
id: GO:0018276
name: isopeptide cross-linking via N6-glycyl-L-lysine
namespace: biological_process
def: "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glycine to produce N6-glycyl-L-lysine. This is distinct from the formation of the thiolester intermediate, which occurs during ubiquitination." [RESID:AA0125]
comment: See also the biological process term 'peptide cross-linking via S-glycyl-L-cysteine ; GO:0018255'.
xref: RESID:AA0125
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018262 ! isopeptide cross-linking
relationship: part_of GO:0016567 ! protein ubiquitination

[Term]
id: GO:0018277
name: protein amino acid deamination
namespace: biological_process
def: "The removal of an amino group from a protein amino acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006464 ! protein modification process

[Term]
id: GO:0018278
name: N-terminal peptidyl-threonine deamination
namespace: biological_process
def: "The deamination of N-terminal peptidyl-threonine to form peptidyl-2-oxobutanoic acid." [RESID:AA0129]
subset: gosubset_prok
xref: RESID:AA0129
is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018279
name: protein amino acid N-linked glycosylation via asparagine
namespace: biological_process
def: "The posttranslational glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine also occurs; this modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [RESID:AA0151]
subset: gosubset_prok
xref: RESID:AA0151
is_a: GO:0006487 ! protein amino acid N-linked glycosylation
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0018280
name: protein amino acid S-linked glycosylation
namespace: biological_process
def: "A protein amino acid glycosylation process in which a sugar unit is added to a protein via a sulfur atom of a peptidyl-amino-acid such as cysteine or methionine." [GOC:ai, GOC:jsg]
subset: gosubset_prok
is_a: GO:0006486 ! protein amino acid glycosylation

[Term]
id: GO:0018281
name: GSI anchor biosynthetic process via N-seryl-glycosylsphingolipidinositolethanolamine
namespace: biological_process
def: "The formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0166]
subset: gosubset_prok
synonym: "GSI anchor anabolism via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT []
synonym: "GSI anchor formation via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT []
synonym: "GSI anchor synthesis via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT []
xref: RESID:AA0166
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0042082 ! GSI anchor biosynthetic process

[Term]
id: GO:0018282
name: metal incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The formation of a cluster of several metal atoms, including iron, nickel, molybdenum, vanadium, or copper, with one or more bridging (mu-bond) sulfur atoms; amino acids residues in proteins that may ligate the metal sulfur cluster are cysteine, histidine, aspartate, glutamate, serine and cysteine persulfide." [GOC:jsg]
subset: gosubset_prok
synonym: "metal incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0043687 ! post-translational protein modification
relationship: part_of GO:0031163 ! metallo-sulfur cluster assembly

[Term]
id: GO:0018283
name: iron incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of iron into a metallo-sulfur cluster." [GOC:ai]
subset: gosubset_prok
synonym: "iron incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0016226 ! iron-sulfur cluster assembly
is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster

[Term]
id: GO:0018284
name: iron incorporation into protein via tetrakis-L-cysteinyl iron
namespace: biological_process
def: "The incorporation of iron into a protein via tetrakis-L-cysteinyl iron (there is no exogenous sulfur, so this modification by itself does not produce an iron-sulfur protein)." [RESID:AA0136]
subset: gosubset_prok
xref: RESID:AA0136
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0018285
name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide
namespace: biological_process
def: "The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide." [RESID:AA0137]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl diiron disulphide" EXACT []
xref: RESID:AA0137
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0018286
name: iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 3Fe-3S iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide. The three-iron three-sulfur cluster probably does not exist except as an intermediate form." [RESID:AA0138]
comment: This term was made obsolete because the three-iron three-sulfur cluster is now thought not to exist except possibly as an intermediate form.
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron trisulphide" EXACT []
is_obsolete: true
consider: GO:0018198
consider: GO:0018283

[Term]
id: GO:0018287
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide." [RESID:AA0139]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron tetrasulphide" EXACT []
xref: RESID:AA0139
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0018288
name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide." [RESID:AA0140]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl tetrairon tetrasulphide" EXACT []
xref: RESID:AA0140
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0018289
name: molybdenum incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of molybdenum into a metallo-sulfur cluster." [GOC:ai]
subset: gosubset_prok
synonym: "molybdenum incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster

[Term]
id: GO:0018290
name: iron and molybdenum incorporation into iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide
namespace: biological_process
def: "The incorporation of iron and molybdenum into a Mo-7Fe-8S iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide, found in nitrogenase." [RESID:AA0141]
subset: gosubset_prok
synonym: "iron and molybdenum incorporation into iron-molybdenum-sulphur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulphide" EXACT []
xref: RESID:AA0141
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0018291 ! molybdenum incorporation into iron-sulfur cluster

[Term]
id: GO:0018291
name: molybdenum incorporation into iron-sulfur cluster
namespace: biological_process
def: "The incorporation of molybdenum into an iron-sulfur cluster." [GOC:ai]
subset: gosubset_prok
synonym: "molybdenum incorporation into iron-sulphur cluster" EXACT []
is_a: GO:0016226 ! iron-sulfur cluster assembly
is_a: GO:0018289 ! molybdenum incorporation into metallo-sulfur cluster

[Term]
id: GO:0018292
name: molybdenum incorporation via L-cysteinyl molybdopterin
namespace: biological_process
def: "The incorporation of molybdenum into a protein via L-cysteinyl molybdopterin." [RESID:AA0142]
subset: gosubset_prok
xref: RESID:AA0142
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex

[Term]
id: GO:0018293
name: protein-FAD linkage
namespace: biological_process
def: "The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018065 ! protein-cofactor linkage

[Term]
id: GO:0018294
name: protein-FAD linkage via S-(8alpha-FAD)-L-cysteine
namespace: biological_process
def: "The formation of a protein-FAD linkage via S-(8-alpha-FAD)-L-cysteine." [RESID:AA0143]
subset: gosubset_prok
xref: RESID:AA0143
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018293 ! protein-FAD linkage

[Term]
id: GO:0018295
name: protein-FAD linkage via 3'-(8alpha-FAD)-L-histidine
namespace: biological_process
def: "The formation of a protein-FAD linkage via 3'-(8-alpha-FAD)-L-histidine." [RESID:AA0144]
subset: gosubset_prok
xref: RESID:AA0144
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018293 ! protein-FAD linkage

[Term]
id: GO:0018296
name: protein-FAD linkage via O4'-(8alpha-FAD)-L-tyrosine
namespace: biological_process
def: "The formation of a protein-FAD linkage via O4'-(8-alpha-FAD)-L-tyrosine." [RESID:AA0145]
subset: gosubset_prok
xref: RESID:AA0145
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0018293 ! protein-FAD linkage

[Term]
id: GO:0018297
name: protein-FAD linkage via 1'-(8alpha-FAD)-L-histidine
namespace: biological_process
def: "The formation of a protein-FAD linkage via 1'-(8-alpha-FAD)-L-histidine." [RESID:AA0221]
subset: gosubset_prok
xref: RESID:AA0221
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018293 ! protein-FAD linkage

[Term]
id: GO:0018298
name: protein-chromophore linkage
namespace: biological_process
def: "The covalent or noncovalent linking of a chromophore to a protein." [GOC:ma]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018299
name: iron incorporation into the Rieske iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide
namespace: biological_process
def: "The incorporation of iron into a Rieske 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide." [RESID:AA0225]
subset: gosubset_prok
synonym: "iron incorporation into the Rieske iron-sulphur cluster via bis-L-cysteinyl bis-L-histidino diiron disulphide" EXACT []
xref: RESID:AA0225
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0018300
name: iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide
namespace: biological_process
def: "OBSOLETE. The incorporation of iron into a 6Fe-6S cluster by hexakis-L-cysteinyl hexairon hexasulfide." [RESID:AA0226]
comment: This term was made obsolete because the prismane 6Fe-6S cluster is now thought not to exist.
synonym: "iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl hexairon hexasulphide" EXACT []
is_obsolete: true
consider: GO:0018198
consider: GO:0018283

[Term]
id: GO:0018301
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon
namespace: biological_process
def: "The incorporation of iron into an iron-sulfur cluster by tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon." [RESID:AA0268]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-cysteine persulphido-bis-L-glutamato-L-histidino tetrairon" EXACT []
xref: RESID:AA0268
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0018302
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide." [RESID:AA0284]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulphide" EXACT []
xref: RESID:AA0284
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0018303
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide." [RESID:AA0285]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulphide" EXACT []
xref: RESID:AA0285
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0018304
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide." [RESID:AA0286]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulphide" EXACT []
xref: RESID:AA0286
is_a: GO:0018197 ! peptidyl-aspartic acid modification
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0018305
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide." [RESID:AA0288]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulphide" EXACT []
xref: RESID:AA0288
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0018306
name: iron incorporation into iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide." [RESID:AA0289]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulphide" EXACT []
xref: RESID:AA0289
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0018307
name: enzyme active site formation
namespace: biological_process
def: "The modification of part of an enzyme to form the active site." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018308
name: enzyme active site formation via N6-pyruvic acid 2-iminyl-L-lysine
namespace: biological_process
def: "OBSOLETE. The transient modification of lysine by pyruvate to form N6-pyruvic acid 2-iminyl-L-lysine, found in the active site of dihydrodipicolinate synthase." [PMID:1463470, RESID:AA0287]
comment: This term was made obsolete because this process does not occur: the modification occurs before it can be an active site.
is_obsolete: true

[Term]
id: GO:0018309
name: protein-FMN linkage
namespace: biological_process
def: "The formation of a linkage between a protein amino acid and flavin mononucleotide (FMN)." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018065 ! protein-cofactor linkage

[Term]
id: GO:0018310
name: protein-FMN linkage via S-(6-FMN)-L-cysteine
namespace: biological_process
def: "The formation of a protein-FMN linkage via S-(6-FMN)-L-cysteine." [RESID:AA0220]
subset: gosubset_prok
xref: RESID:AA0220
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018309 ! protein-FMN linkage

[Term]
id: GO:0018311
name: peptidyl-N4-hydroxymethyl-L-asparagine biosynthetic process from peptidyl-asparagine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of N4-hydroxymethyl-L-asparagine from other compounds, including peptidyl-asparagine." [RESID:AA0236]
subset: gosubset_prok
synonym: "peptidyl-N4-hydroxymethyl-L-asparagine anabolism from peptidyl-asparagine" EXACT []
synonym: "peptidyl-N4-hydroxymethyl-L-asparagine formation from peptidyl-asparagine" EXACT []
synonym: "peptidyl-N4-hydroxymethyl-L-asparagine synthesis from peptidyl-asparagine" EXACT []
xref: RESID:AA0236
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0018312
name: peptidyl-serine ADP-ribosylation
namespace: biological_process
def: "The transfer, from NAD, of ADP-ribose to peptidyl-serine to form peptidyl-O-(ADP-ribosyl)-L-serine." [RESID:AA0237]
subset: gosubset_prok
xref: RESID:AA0237
is_a: GO:0006471 ! protein amino acid ADP-ribosylation
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018313
name: peptide cross-linking via L-alanyl-5-imidazolinone glycine
namespace: biological_process
def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, an alanine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0187]
subset: gosubset_prok
xref: RESID:AA0187
is_a: GO:0018194 ! peptidyl-alanine modification
is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine

[Term]
id: GO:0018314
name: protein-pyrroloquinoline-quinone linkage
namespace: biological_process
def: "OBSOLETE. The covalent cross-linking of pyrroloquinoline-quinone to peptidyl-glutamic acid and peptidyl-tyrosine." [PMID:7665488, RESID:AA0283]
is_obsolete: true
replaced_by: GO:0006464

[Term]
id: GO:0018315
name: molybdenum incorporation into molybdenum-molybdopterin complex
namespace: biological_process
alt_id: GO:0042041
def: "The incorporation of molybdenum into a molybdenum-molybdopterin complex." [GOC:ai]
subset: gosubset_prok
synonym: "molybdenum incorporation into metallo-pterin complex" EXACT []
is_a: GO:0042040 ! metal incorporation into metallo-molybdopterin complex

[Term]
id: GO:0018316
name: peptide cross-linking via L-cystine
namespace: biological_process
def: "The oxidation of two peptidyl-cysteine residues to form a peptidyl-L-cystine (dicysteine) in which segments of peptide chain are linked by a disulfide bond; the cross-link may be between different or the same peptide chain." [RESID:AA0025]
subset: gosubset_prok
xref: RESID:AA0025
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018317
name: protein amino acid C-linked glycosylation via tryptophan
namespace: biological_process
def: "The glycosylation of a carbon atom of a peptidyl-tryptophan residue." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018103 ! protein amino acid C-linked glycosylation
is_a: GO:0018211 ! peptidyl-tryptophan modification

[Term]
id: GO:0018318
name: protein amino acid palmitoylation
namespace: biological_process
alt_id: GO:0018349
def: "The covalent or non-covalent attachment of a palmitoyl moiety to a protein amino acid." [GOC:jl]
subset: gosubset_prok
is_a: GO:0018345 ! protein palmitoylation

[Term]
id: GO:0018319
name: protein amino acid myristoylation
namespace: biological_process
def: "The covalent or non-covalent attachment of a myristoyl moiety to a protein amino acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018377 ! protein myristoylation

[Term]
id: GO:0018320
name: enzyme active site formation via S-methyl-L-cysteine
namespace: biological_process
def: "The transient methylation of peptidyl-cysteine to form S-methyl-L-cysteine." [RESID:AA0234]
subset: gosubset_prok
xref: RESID:AA0234
is_a: GO:0018125 ! peptidyl-cysteine methylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018321
name: protein amino acid glucuronylation
namespace: biological_process
def: "The modification of a protein by amino acid glucuronylation, the addition of a glucuronate group, the uronic acid derived from glucose." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006486 ! protein amino acid glycosylation

[Term]
id: GO:0018322
name: protein amino acid tyrosinylation
namespace: biological_process
def: "The addition of a tyrosine molecule to a protein amino acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018323
name: enzyme active site formation via L-cysteine sulfinic acid
namespace: biological_process
def: "The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfinic acid." [RESID:AA0262]
subset: gosubset_prok
synonym: "enzyme active site formation via L-cysteine sulphinic acid" EXACT []
xref: RESID:AA0262
is_a: GO:0018171 ! peptidyl-cysteine oxidation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018324
name: enzyme active site formation via L-cysteine sulfenic acid
namespace: biological_process
def: "The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfenic acid, found in the active site of NADH peroxidase, nitrile hydratase, and peptide methionine sulfoxide reductase." [PMID:2501303, RESID:AA0205]
subset: gosubset_prok
synonym: "enzyme active site formation via L-cysteine sulphenic acid" EXACT []
xref: RESID:AA0205
is_a: GO:0018171 ! peptidyl-cysteine oxidation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018325
name: enzyme active site formation via S-phospho-L-cysteine
namespace: biological_process
def: "The transient phosphorylation of peptidyl-cysteine to form S-phospho-L-cysteine." [RESID:AA0034]
subset: gosubset_prok
xref: RESID:AA0034
is_a: GO:0018218 ! peptidyl-cysteine phosphorylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018326
name: enzyme active site formation via S-acetyl-L-cysteine
namespace: biological_process
def: "The transient acetylation of peptidyl-cysteine to form S-acetyl-L-cysteine." [RESID:AA0056]
subset: gosubset_prok
xref: RESID:AA0056
is_a: GO:0018219 ! peptidyl-cysteine S-acetylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018327
name: enzyme active site formation via 1'-phospho-L-histidine
namespace: biological_process
def: "The transient phosphorylation of peptidyl-histidine to form 1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine)." [RESID:AA0035]
subset: gosubset_prok
xref: RESID:AA0035
is_a: GO:0018106 ! peptidyl-histidine phosphorylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018328
name: enzyme active site formation via 3'-phospho-L-histidine
namespace: biological_process
def: "The transient phosphorylation of peptidyl-histidine to form 3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0036]
subset: gosubset_prok
xref: RESID:AA0036
is_a: GO:0018106 ! peptidyl-histidine phosphorylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018329
name: enzyme active site formation via N6-(phospho-5'-adenosine)-L-lysine
namespace: biological_process
def: "The transient adenylylation of lysine to form N6-(phospho-5'-adenosine)-L-lysine, found in the active site of DNA ligase and RNA ligase." [RESID:AA0227]
subset: gosubset_prok
xref: RESID:AA0227
is_a: GO:0018116 ! peptidyl-lysine adenylylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018330
name: enzyme active site formation via N6-(phospho-5'-guanosine)-L-lysine
namespace: biological_process
def: "The transient guanylylation of lysine to form N6-(phospho-5'-guanosine)-L-lysine, found in the guanylyltransferase active site of mRNA capping enzyme." [RESID:AA0228]
subset: gosubset_prok
xref: RESID:AA0228
is_a: GO:0018261 ! peptidyl-lysine guanylylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018331
name: enzyme active site formation via O-phospho-L-serine
namespace: biological_process
def: "The transient phosphorylation of peptidyl-serine to form O-phospho-L-serine." [RESID:AA0037]
subset: gosubset_prok
xref: RESID:AA0037
is_a: GO:0018105 ! peptidyl-serine phosphorylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018332
name: enzyme active site formation via O-(phospho-5'-adenosine)-L-threonine
namespace: biological_process
def: "The transient adenylylation of threonine to form N6-(phospho-5'-adenosine)-L-threonine, found in the active site of bovine phosphodiesterase I." [RESID:AA0267]
subset: gosubset_prok
xref: RESID:AA0267
is_a: GO:0018178 ! peptidyl-threonine adenylylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018333
name: enzyme active site formation via O-phospho-L-threonine
namespace: biological_process
def: "The transient phosphorylation of peptidyl-threonine to form O-phospho-L-threonine." [RESID:AA0038]
subset: gosubset_prok
xref: RESID:AA0038
is_a: GO:0018107 ! peptidyl-threonine phosphorylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018334
name: enzyme active site formation via O4'-phospho-L-tyrosine
namespace: biological_process
def: "The transient phosphorylation of peptidyl-tyrosine to form O-phospho-L-tyrosine." [RESID:AA0039]
subset: gosubset_prok
xref: RESID:AA0039
is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018335
name: protein amino acid succinylation
namespace: biological_process
def: "The modification of a protein amino acid by succinylation." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018336
name: peptidyl-tyrosine hydroxylation
namespace: biological_process
def: "The hydroxylation of peptidyl-tyrosine to form peptidyl-dihydroxyphenylalanine." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018126 ! protein amino acid hydroxylation

[Term]
id: GO:0018337
name: enzyme active site formation via L-2',4',5'-topaquinone
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because this process does not occur: the modification occurs before it can be an active site.
is_obsolete: true

[Term]
id: GO:0018338
name: protein amino acid cinnamylation
namespace: biological_process
def: "OBSOLETE. The modification of a protein amino acid by cinnamylation." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0018097

[Term]
id: GO:0018339
name: peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid
namespace: biological_process
def: "The posttranslation modification of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid, typical of bacterial ribosomal protein S12." [RESID:AA0232]
subset: gosubset_prok
synonym: "peptidyl-L-beta-methylthioaspartic acid anabolism from peptidyl-aspartic acid" EXACT []
synonym: "peptidyl-L-beta-methylthioaspartic acid formation from peptidyl-aspartic acid" EXACT []
synonym: "peptidyl-L-beta-methylthioaspartic acid synthesis from peptidyl-aspartic acid" EXACT []
xref: RESID:AA0232
is_a: GO:0018197 ! peptidyl-aspartic acid modification
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018340
name: peptidyl-O-(sn-1-glycerophosphoryl)-L-serine biosynthetic process from peptidyl-serine
namespace: biological_process
def: "The posttranslational modification of peptidyl-serine to peptidyl-O-(sn-1-glycerophosphoryl)-L-serine." [RESID:AA0264]
subset: gosubset_prok
synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine anabolism from peptidyl-serine" EXACT []
synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine formation from peptidyl-serine" EXACT []
synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine synthesis from peptidyl-serine" EXACT []
xref: RESID:AA0264
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018341
name: peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthetic process
namespace: biological_process
subset: gosubset_prok
synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine anabolism" EXACT []
synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthesis" EXACT []
synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine formation" EXACT []
synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine synthesis" EXACT []
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018342
name: protein prenylation
namespace: biological_process
def: "The enzymatic addition of prenyl moieties to proteins as a posttranslational modification; geranyl, farnesyl, or geranylgeranyl groups may be added." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0006497 ! protein amino acid lipidation

[Term]
id: GO:0018343
name: protein farnesylation
namespace: biological_process
def: "The enzymatic addition of a farnesyl moiety to a protein as a posttranslational modification." [GOC:jl]
subset: gosubset_prok
is_a: GO:0018342 ! protein prenylation

[Term]
id: GO:0018344
name: protein geranylgeranylation
namespace: biological_process
def: "The enzymatic addition of a geranylgeranyl moiety to a protein as a posttranslational modification." [GOC:jl]
subset: gosubset_prok
is_a: GO:0018342 ! protein prenylation

[Term]
id: GO:0018345
name: protein palmitoylation
namespace: biological_process
def: "The covalent or non-covalent attachment of a palmitoyl moiety to a protein." [GOC:jl]
subset: gosubset_prok
is_a: GO:0006497 ! protein amino acid lipidation
is_a: GO:0043543 ! protein amino acid acylation

[Term]
id: GO:0018346
name: protein amino acid prenylation
namespace: biological_process
def: "The covalent attachment of a prenyl moiety to a protein amino acid." [GOC:jl]
subset: gosubset_prok
synonym: "C-terminal protein prenylation" NARROW []
is_a: GO:0018342 ! protein prenylation

[Term]
id: GO:0018347
name: protein amino acid farnesylation
namespace: biological_process
def: "The covalent attachment of a farnesyl moiety to a protein amino acid." [GOC:jl]
subset: gosubset_prok
synonym: "C-terminal protein farnesylation" NARROW []
is_a: GO:0018343 ! protein farnesylation
is_a: GO:0018346 ! protein amino acid prenylation

[Term]
id: GO:0018348
name: protein amino acid geranylgeranylation
namespace: biological_process
def: "The covalent attachment of a geranylgeranyl moiety to a protein amino acid." [GOC:jl]
subset: gosubset_prok
synonym: "C-terminal protein geranylgeranylation" NARROW []
is_a: GO:0018344 ! protein geranylgeranylation
is_a: GO:0018346 ! protein amino acid prenylation

[Term]
id: GO:0018350
name: protein amino acid esterification
namespace: biological_process
def: "The addition of an ester group to a protein amino acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018351
name: peptidyl-cysteine esterification
namespace: biological_process
def: "The addition of an ester group to a cysteine residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018350 ! protein amino acid esterification

[Term]
id: GO:0018352
name: protein-pyridoxal-5-phosphate linkage
namespace: biological_process
subset: gosubset_prok
is_a: GO:0018065 ! protein-cofactor linkage

[Term]
id: GO:0018353
name: protein-phycocyanobilin linkage via S-phycocyanobilin-L-cysteine
namespace: biological_process
alt_id: GO:0018380
def: "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin via S-phycocyanobilin-L-cysteine." [RESID:AA0131]
subset: gosubset_prok
xref: RESID:AA0131
is_a: GO:0017009 ! protein-phycocyanobilin linkage
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018355
name: protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine
namespace: biological_process
subset: gosubset_prok
is_a: GO:0018247 ! protein-phosphoribosyl dephospho-coenzyme A linkage

[Term]
id: GO:0018356
name: protein-phycobiliviolin linkage via S-phycobiliviolin-L-cysteine
namespace: biological_process
alt_id: GO:0018382
def: "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin via S-phycobiliviolin-L-cysteine." [RESID:AA0258]
subset: gosubset_prok
xref: RESID:AA0258
is_a: GO:0017008 ! protein-phycobiliviolin linkage

[Term]
id: GO:0018357
name: protein-phycourobilin linkage via phycourobilin-bis-L-cysteine
namespace: biological_process
alt_id: GO:0018383
def: "The linkage of the chromophore phycourobilin to phycoerythrins via phycourobilin-bis-L-cysteine." [RESID:AA0260]
subset: gosubset_prok
xref: RESID:AA0260
is_a: GO:0017010 ! protein-phycourobilin linkage
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018358
name: protein-phytochromobilin linkage via S-phytochromobilin-L-cysteine
namespace: biological_process
alt_id: GO:0018381
def: "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin via S-phytochromobilin-L-cysteine." [RESID:AA0133]
subset: gosubset_prok
xref: RESID:AA0133
is_a: GO:0017012 ! protein-phytochromobilin linkage
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018359
name: protein-heme P460 linkage via heme P460-bis-L-cysteine-L-tyrosine
namespace: biological_process
alt_id: GO:0018385
def: "The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-tyrosine." [RESID:AA0266]
subset: gosubset_prok
synonym: "protein-haem P460 linkage via haem P460-bis-L-cysteine-L-tyrosine" EXACT []
xref: RESID:AA0266
is_a: GO:0018174 ! protein-heme P460 linkage
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0018360
name: protein-heme P460 linkage via heme P460-bis-L-cysteine-L-lysine
namespace: biological_process
alt_id: GO:0018384
def: "The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-lysine." [RESID:AA0271]
subset: gosubset_prok
synonym: "protein-haem P460 linkage via haem P460-bis-L-cysteine-L-lysine" EXACT []
xref: RESID:AA0271
is_a: GO:0018174 ! protein-heme P460 linkage
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018361
name: peptidyl-glutamine 2-methylation
namespace: biological_process
def: "The methylation of glutamine to form 2-methyl-L-glutamine." [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0273]
subset: gosubset_prok
xref: RESID:AA0273
is_a: GO:0018364 ! peptidyl-glutamine methylation

[Term]
id: GO:0018362
name: peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester
namespace: biological_process
alt_id: GO:0019924
def: "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester." [RESID:AA0279]
subset: gosubset_prok
synonym: "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester" EXACT []
xref: RESID:AA0279
is_a: GO:0018186 ! peroxidase-heme linkage
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018363
name: peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium
namespace: biological_process
alt_id: GO:0019925
def: "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium." [RESID:AA0280]
subset: gosubset_prok
synonym: "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium" EXACT []
synonym: "peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulphonium" EXACT []
xref: RESID:AA0280
is_a: GO:0018186 ! peroxidase-heme linkage
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018206 ! peptidyl-methionine modification

[Term]
id: GO:0018364
name: peptidyl-glutamine methylation
namespace: biological_process
def: "The addition of a methyl group to a glutamine residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006479 ! protein amino acid methylation

[Term]
id: GO:0018365
name: protein-serine epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine." [EC:5.1.1.16]
synonym: "protein-serine racemase activity" EXACT [EC:5.1.1.16]
xref: EC:5.1.1.16
xref: MetaCyc:5.1.1.16-RXN
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives

[Term]
id: GO:0018366
name: chiral amino acid racemization
namespace: biological_process
def: "The formation of a mixture of the two possible enantiomers from the D- or L-enantiomer of a chiral amino acid." [GOC:jsg, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0018367
name: free L-amino acid racemization
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it is not clear that this process occurs.
is_obsolete: true
consider: GO:0006520

[Term]
id: GO:0018376
name: peptidyl-asparagine hydroxylation to form L-erythro-beta-hydroxyasparagine
namespace: biological_process
def: "The posttranslational hydroxylation of peptidyl-asparagine to form peptidyl-L-erythro-beta-hydroxyasparagine; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0026]
comment: See also the molecular function term 'peptide-aspartate beta-dioxygenase activity ; GO:0004597'.
subset: gosubset_prok
xref: RESID:AA0026
is_a: GO:0042265 ! peptidyl-asparagine hydroxylation

[Term]
id: GO:0018377
name: protein myristoylation
namespace: biological_process
def: "The covalent or non-covalent attachment of a myristoyl moiety to a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006497 ! protein amino acid lipidation
is_a: GO:0043543 ! protein amino acid acylation

[Term]
id: GO:0018378
name: cytochrome c-heme linkage via heme-L-cysteine
namespace: biological_process
def: "The linkage of cytochromes and other heme proteins to heme via heme-L-cysteine." [RESID:AA0135]
subset: gosubset_prok
synonym: "cytochrome c-haem linkage via haem-L-cysteine" EXACT []
xref: RESID:AA0135
is_a: GO:0018063 ! cytochrome c-heme linkage
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018379
name: cytochrome c-heme linkage via heme-bis-L-cysteine
namespace: biological_process
def: "The linkage of cytochromes and other heme proteins to heme via heme-bis-L-cysteine." [RESID:AA0134]
subset: gosubset_prok
synonym: "cytochrome c-haem linkage via haem-bis-L-cysteine" EXACT []
xref: RESID:AA0134
is_a: GO:0018063 ! cytochrome c-heme linkage
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018386
name: N-terminal peptidyl-cysteine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-cysteine
namespace: biological_process
def: "The condensation of pyruvate through the 2-oxo group with the N-terminal cysteine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-cysteine." [RESID:AA0274]
subset: gosubset_prok
xref: RESID:AA0274
is_a: GO:0018060 ! N-terminal peptidyl-cysteine deamination

[Term]
id: GO:0018387
name: N-terminal peptidyl-amino acid deamination to pyruvic acid
namespace: biological_process
def: "The oxidative deamination of N-terminal peptidyl-cysteine, or peptidyl-serine, to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127]
subset: gosubset_prok
xref: RESID:AA0127
is_a: GO:0018059 ! N-terminal peptidyl-serine deamination
is_a: GO:0018060 ! N-terminal peptidyl-cysteine deamination
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018388
name: N-terminal peptidyl-valine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-valine
namespace: biological_process
def: "The condensation of pyruvate through the 2-oxo group with the N-terminal valine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-valine." [RESID:AA0275]
subset: gosubset_prok
xref: RESID:AA0275
is_a: GO:0018213 ! peptidyl-valine modification
is_a: GO:0018409 ! peptide or protein amino-terminal blocking

[Term]
id: GO:0018389
name: N-terminal peptidyl-valine deamination
namespace: biological_process
def: "The deamination of the N-terminal valine residue of a protein to form isobutyrate." [GOC:ma, GOC:mah]
subset: gosubset_prok
is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon

[Term]
id: GO:0018390
name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine
namespace: biological_process
def: "The methyl esterification of peptidyl-glutamic acid or peptidyl-glutamine to form the derivative glutamic acid 5-methyl ester." [RESID:AA0072]
subset: gosubset_prok
synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from peptidyl-glutamic acid or peptidyl-glutamine" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from peptidyl-glutamic acid or peptidyl-glutamine" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from peptidyl-glutamic acid or peptidyl-glutamine" EXACT []
xref: RESID:AA0072
is_a: GO:0018199 ! peptidyl-glutamine modification
is_a: GO:0018442 ! peptidyl-glutamic acid esterification

[Term]
id: GO:0018391
name: C-terminal peptidyl-glutamic acid tyrosinylation
namespace: biological_process
subset: gosubset_prok
is_a: GO:0018166 ! C-terminal protein-tyrosinylation
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018392
name: glycoprotein 3-alpha-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-fucose + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine = GDP + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-beta-D-glucosaminyl}asparagine." [EC:2.4.1.214]
synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha-1->6-GlcNAc)-Asn-peptide) alpha-1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214]
synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6-GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214]
synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214]
synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha-1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214]
synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214]
synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214]
synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214]
synonym: "GDP-L-fucose:asparagine-linked N-acetylglucosamine alpha(1,3)-fucosyltransferase activity" EXACT []
synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" EXACT [EC:2.4.1.214]
synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" EXACT [EC:2.4.1.214]
xref: EC:2.4.1.214
xref: MetaCyc:2.4.1.214-RXN
is_a: GO:0046920 ! alpha(1,3)-fucosyltransferase activity

[Term]
id: GO:0018393
name: internal peptidyl-lysine acetylation
namespace: biological_process
def: "The addition of an acetyl group to a non-terminal lysine residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006475 ! internal protein amino acid acetylation
is_a: GO:0018394 ! peptidyl-lysine acetylation

[Term]
id: GO:0018394
name: peptidyl-lysine acetylation
namespace: biological_process
def: "The acetylation of peptidyl-lysine." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006473 ! protein amino acid acetylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018395
name: peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine
namespace: biological_process
def: "The hydroxylation of peptidyl-lysine to peptidyl-5-hydroxy-L-lysine." [RESID:AA0028]
subset: gosubset_prok
xref: RESID:AA0028
is_a: GO:0017185 ! peptidyl-lysine hydroxylation

[Term]
id: GO:0018396
name: peptidyl-lysine hydroxylation to 4-hydroxy-L-lysine
namespace: biological_process
def: "The hydroxylation of peptidyl-lysine to peptidyl-4-hydroxy-L-lysine." [RESID:AA0235]
subset: gosubset_prok
xref: RESID:AA0235
is_a: GO:0017185 ! peptidyl-lysine hydroxylation

[Term]
id: GO:0018397
name: peptidyl-phenylalanine bromination to L-2'-bromophenylalanine
namespace: biological_process
def: "The posttranslational bromination of peptidyl-phenylalanine to form L-2'-bromophenylalanine." [RESID:AA0174]
subset: gosubset_prok
xref: RESID:AA0174
is_a: GO:0018075 ! peptidyl-phenylalanine bromination

[Term]
id: GO:0018398
name: peptidyl-phenylalanine bromination to L-3'-bromophenylalanine
namespace: biological_process
def: "The posttranslational bromination of peptidyl-phenylalanine to form L-3'-bromophenylalanine." [RESID:AA0175]
subset: gosubset_prok
xref: RESID:AA0175
is_a: GO:0018075 ! peptidyl-phenylalanine bromination

[Term]
id: GO:0018399
name: peptidyl-phenylalanine bromination to L-4'-bromophenylalanine
namespace: biological_process
def: "The posttranslational bromination of peptidyl-phenylalanine to form L-4'-bromophenylalanine." [RESID:AA0176]
subset: gosubset_prok
xref: RESID:AA0176
is_a: GO:0018075 ! peptidyl-phenylalanine bromination

[Term]
id: GO:0018400
name: peptidyl-proline hydroxylation to 3-hydroxy-L-proline
namespace: biological_process
def: "The posttranslational modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase." [RESID:AA0029]
comment: See also the molecular function term 'procollagen-proline 3-dioxygenase activity ; GO:0019797'.
subset: gosubset_prok
xref: RESID:AA0029
is_a: GO:0019511 ! peptidyl-proline hydroxylation

[Term]
id: GO:0018401
name: peptidyl-proline hydroxylation to 4-hydroxy-L-proline
namespace: biological_process
def: "The posttranslational modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]
comment: See also the molecular function term 'procollagen-proline 4-dioxygenase activity ; GO:0004656'.
subset: gosubset_prok
xref: RESID:AA0030
is_a: GO:0019471 ! 4-hydroxyproline metabolic process
is_a: GO:0019511 ! peptidyl-proline hydroxylation

[Term]
id: GO:0018402
name: protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine
namespace: biological_process
def: "Chondroitin sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0208]
subset: gosubset_prok
synonym: "protein-chondroitin sulphate linkage via chondroitin sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT []
xref: RESID:AA0208
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0030204 ! chondroitin sulfate metabolic process

[Term]
id: GO:0018403
name: protein-dermatan sulfate linkage via dermatan 4-sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine
namespace: biological_process
def: "Dermatan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [PMID:7338506, RESID:AA0209]
subset: gosubset_prok
synonym: "protein-dermatan sulphate linkage via dermatan 4-sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT []
xref: RESID:AA0209
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018404
name: protein-heparan sulfate linkage via heparan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine
namespace: biological_process
def: "Heparan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0210]
subset: gosubset_prok
synonym: "protein-heparan sulphate linkage via heparan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT []
xref: RESID:AA0210
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0018405
name: protein-keratan sulfate linkage via keratan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine
namespace: biological_process
def: "Keratan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and threonine residues." [RESID:AA0247]
subset: gosubset_prok
synonym: "protein-keratan sulphate linkage via keratan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine" EXACT []
xref: RESID:AA0247
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0018406
name: protein amino acid C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan
namespace: biological_process
alt_id: GO:0032004
def: "The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring." [PMID:7947762, PMID:9450955, RESID:AA0217]
synonym: "protein amino acid C-linked mannosylation" EXACT []
xref: RESID:AA0217
is_a: GO:0018317 ! protein amino acid C-linked glycosylation via tryptophan
is_a: GO:0035268 ! protein amino acid mannosylation

[Term]
id: GO:0018407
name: peptidyl-thyronine iodination to form 3',3'',5'-triiodo-L-thyronine
namespace: biological_process
def: "The posttranslational iodination of peptidyl-thyronine to form peptidyl-3',3'',5'-triiodo-L-thyronine (triiodothyronine)." [RESID:AA0177]
subset: gosubset_prok
synonym: "peptidyl-thyronine iodination to form triiodothyronine" BROAD []
xref: RESID:AA0177
is_a: GO:0018078 ! peptidyl-thyronine iodination

[Term]
id: GO:0018408
name: peptidyl-thyronine iodination to form 3',3'',5',5''-tetraiodo-L-thyronine
namespace: biological_process
def: "The posttranslational iodination of peptidyl-thyronine to form peptidyl-3',3'',5',5''-tetraiodo-L-thyronine (L-thyroxine)." [RESID:AA0178]
subset: gosubset_prok
xref: RESID:AA0178
is_a: GO:0018078 ! peptidyl-thyronine iodination

[Term]
id: GO:0018409
name: peptide or protein amino-terminal blocking
namespace: biological_process
subset: gosubset_prok
synonym: "peptide/protein amino-terminal blocking" EXACT []
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0018410
name: peptide or protein carboxyl-terminal blocking
namespace: biological_process
subset: gosubset_prok
synonym: "peptide/protein carboxyl-terminal blocking" EXACT []
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018411
name: protein amino acid glucuronidation
namespace: biological_process
def: "The modification of a protein by amino acid glucuronidation." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0018412
name: protein amino acid O-glucuronidation
namespace: biological_process
subset: gosubset_prok
is_a: GO:0018411 ! protein amino acid glucuronidation

[Term]
id: GO:0018413
name: peptidyl-serine O-glucuronidation
namespace: biological_process
def: "The O-glucuronidation of peptidyl-serine to form peptidyl-O3-D-glucuronyl-L-serine." [RESID:AA0291]
subset: gosubset_prok
xref: RESID:AA0291
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018412 ! protein amino acid O-glucuronidation

[Term]
id: GO:0018414
name: nickel incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of nickel into a metallo-sulfur cluster." [GOC:ai]
subset: gosubset_prok
synonym: "nickel incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster

[Term]
id: GO:0018415
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide
namespace: biological_process
def: "The incorporation of iron into a 3Fe-2S cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide" EXACT []
xref: RESID:AA0292
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0018416
name: nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide
namespace: biological_process
def: "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292]
subset: gosubset_prok
synonym: "nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide" EXACT []
xref: RESID:AA0292
is_a: GO:0016226 ! iron-sulfur cluster assembly
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster

[Term]
id: GO:0018417
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide
namespace: biological_process
def: "The incorporation of iron into a 3Fe-2S cluster by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide" EXACT []
xref: RESID:AA0293
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0018418
name: nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide
namespace: biological_process
def: "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293]
subset: gosubset_prok
synonym: "nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide" EXACT []
xref: RESID:AA0
is_a: GO:0016226 ! iron-sulfur cluster assembly
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster

[Term]
id: GO:0018419
name: protein catenane formation
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a protein structure comprising two or more rings that are interlocked but not covalently joined; resembling the links of a chain." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0018420
name: peptide cross-linking via N6-(L-isoaspartyl)-L-lysine
namespace: biological_process
def: "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues." [RESID:AA0294]
subset: gosubset_prok
xref: RESID:AA0294
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018196 ! peptidyl-asparagine modification
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0018421
name: UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity
namespace: molecular_function
xref: EC:2.7.8.-
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0018422
name: GDP-mannose:serine-protein mannose-1-phosphotransferase activity
namespace: molecular_function
xref: EC:2.7.8.-
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0018423
name: protein-leucine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester; this reaction is the methylation of peptidyl-L-leucine to form peptidyl-L-leucine methyl ester." [PMID:8514774]
synonym: "protein phosphatase methyltransferase activity" NARROW []
xref: EC:2.1.1.-
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0018424
name: peptidyl-glutamic acid poly-ADP-ribosylation
namespace: biological_process
def: "This modification produces peptidyl-glutamic acid poly-ADP-ribose found in a number of nuclear proteins under certain conditions including the repair of single strand DNA breaks. The activated form of the generating enzyme poly(ADP-ribose) polymerase is itself modified in this way." [RESID:AA0295]
subset: gosubset_prok
xref: RESID:AA0295
is_a: GO:0006471 ! protein amino acid ADP-ribosylation
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0018425
name: O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of O3-(N-acetylglucosamine-1-phosphoryl)-L-serine. The recovery of O-phosphorylserine from acid hydrolysates suggests N-acetylglucosamine-1-phosphate residues are esterified to peptidyl serines through phosphoester bonds." [RESID:AA0296]
subset: gosubset_prok
synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine anabolism" EXACT []
synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthesis" EXACT []
synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine formation" EXACT []
synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine synthesis" EXACT []
xref: RESID:AA0296
is_a: GO:0042077 ! protein amino acid phosphate-linked glycosylation via serine
is_a: GO:0046349 ! amino sugar biosynthetic process

[Term]
id: GO:0018426
name: O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. The polypeptide backbones of glycoproteins and mucin-like proteoglycans are extensively modified with a complex array of phosphoglycan chains that are linked to Ser/Thr-rich domains via a common Man-alpha1-PO4-Ser linkage." [RESID:AA0297]
subset: gosubset_prok
synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine anabolism" EXACT []
synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthesis" EXACT []
synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine formation" EXACT []
synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine synthesis" EXACT []
xref: RESID:AA0297
is_a: GO:0042077 ! protein amino acid phosphate-linked glycosylation via serine

[Term]
id: GO:0018427
name: copper incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of copper into a metallo-sulfur cluster." [GOC:ai]
subset: gosubset_prok
synonym: "copper incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster

[Term]
id: GO:0018428
name: copper incorporation into copper-sulfur cluster
namespace: biological_process
def: "The incorporation of copper into a copper-sulfur cluster." [GOC:ai]
subset: gosubset_prok
synonym: "copper incorporation into copper-sulphur cluster" EXACT []
is_a: GO:0018427 ! copper incorporation into metallo-sulfur cluster

[Term]
id: GO:0018429
name: copper incorporation into copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide
namespace: biological_process
def: "The incorporation of copper into a 4Cu-S copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide." [RESID:AA0298]
subset: gosubset_prok
synonym: "copper incorporation into copper-sulphur cluster via heptakis-L-histidino tetracopper mu4-sulphide hydroxide" EXACT []
xref: RESID:AA0298
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018428 ! copper incorporation into copper-sulfur cluster

[Term]
id: GO:0018439
name: peptidyl-leucine esterification
namespace: biological_process
alt_id: GO:0018440
def: "The chemical reactions and pathways resulting in the formation of peptidyl-L-leucine methyl ester." [RESID:AA0299]
subset: gosubset_prok
xref: RESID:AA0299
is_a: GO:0018203 ! peptidyl-isoleucine modification
is_a: GO:0018350 ! protein amino acid esterification

[Term]
id: GO:0018441
name: iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide
namespace: biological_process
def: "The incorporation of iron into a 8Fe-7S iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide, found in nitrogenase." [PMID:9063865, RESID:AA0300]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulphide" EXACT []
xref: RESID:AA0300
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0018418 ! nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide

[Term]
id: GO:0018442
name: peptidyl-glutamic acid esterification
namespace: biological_process
def: "The addition of an ester group to a glutamic acid residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018350 ! protein amino acid esterification

[Term]
id: GO:0018443
name: enzyme active site formation via L-aspartic 4-phosphoric anhydride
namespace: biological_process
def: "The transient phosphorylation of peptidyl-aspartic acid to form L-aspartic 4-phosphoric anhydride." [RESID:AA0033]
subset: gosubset_prok
xref: RESID:AA0033
is_a: GO:0018217 ! peptidyl-aspartic acid phosphorylation
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0018444
name: translation release factor complex
namespace: cellular_component
def: "A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]
synonym: "eukaryotic peptide chain release factor" EXACT []
synonym: "peptide chain release factor" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0018445
name: prothoracicotrophic hormone activity
namespace: molecular_function
def: "The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects." [GOC:mah, PMID:3301403]
is_a: GO:0005184 ! neuropeptide hormone activity

[Term]
id: GO:0018446
name: pinocarveol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-." [UM-BBD_enzymeID:e0449]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0449
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0018447
name: chloral hydrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: chloral hydrate = 3 H+ + 2 e- + trichloroacetate OR chloral hydrate + H2 = H2O + trichloroethanol." [UM-BBD_enzymeID:e0229]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0229
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0018448
name: hydroxymethylmethylsilanediol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O." [UM-BBD_enzymeID:e0326]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0326
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0018449
name: 1-phenylethanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2." [UM-BBD_enzymeID:e0210]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0210
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0018450
name: myrtenol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal." [UM-BBD_enzymeID:e0444]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0444
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0018451
name: epoxide dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethene oxide (ethylene oxide) + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA." [UM-BBD_enzymeID:e0398]
xref: EC:1.1.1.-
xref: UM-BBD_enzymeID:e0398
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018452
name: 5-exo-hydroxycamphor dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane." [UM-BBD_enzymeID:e0301]
xref: EC:1.1.1.-
xref: MetaCyc:R542-RXN
xref: UM-BBD_enzymeID:e0301
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018453
name: 2-hydroxytetrahydrofuran dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone." [UM-BBD_enzymeID:e0016]
xref: EC:1.1.1.-
xref: UM-BBD_enzymeID:e0016
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018454
name: acetoacetyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+." [EC:1.1.1.36]
subset: gosubset_prok
synonym: "(R)-3-hydroxyacyl-CoA dehydrogenase activity" EXACT [EC:1.1.1.36]
synonym: "(R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.36]
synonym: "acetoacetyl coenzyme A reductase activity" EXACT [EC:1.1.1.36]
synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.36]
synonym: "D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase activity" EXACT [EC:1.1.1.36]
synonym: "D-3-hydroxyacyl-CoA reductase activity" EXACT [EC:1.1.1.36]
synonym: "hydroxyacyl coenzyme-A dehydrogenase activity" EXACT [EC:1.1.1.36]
synonym: "NADP-linked acetoacetyl CoA reductase activity" EXACT [EC:1.1.1.36]
synonym: "NADPH:acetoacetyl-CoA reductase activity" EXACT [EC:1.1.1.36]
synonym: "short chain beta-ketoacetyl(acetoacetyl)-CoA reductase activity" EXACT [EC:1.1.1.36]
xref: EC:1.1.1.36
xref: MetaCyc:RXN-7698
xref: UM-BBD_enzymeID:e0005
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018455
name: alcohol dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+." [EC:1.1.1.71]
synonym: "alcohol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.71]
synonym: "aldehyde reductase (NADPH/NADH)" EXACT [EC:1.1.1.71]
synonym: "retinal reductase activity" NARROW [EC:1.1.1.71]
xref: EC:1.1.1.71
xref: MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN
xref: UM-BBD_enzymeID:e0169
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018456
name: aryl-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+." [EC:1.1.1.90]
subset: gosubset_prok
synonym: "aryl-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.90]
synonym: "benzyl alcohol dehydrogenase activity" NARROW []
synonym: "coniferyl alcohol dehydrogenase" BROAD [EC:1.1.1.90]
synonym: "p-hydroxybenzyl alcohol dehydrogenase activity" NARROW [EC:1.1.1.90]
xref: EC:1.1.1.90
xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0019
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018457
name: perillyl-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: perillyl alcohol + NAD+ = perillyl aldehyde + NADH + H+." [EC:1.1.1.144]
synonym: "perillyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.144]
synonym: "perillyl-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.144]
xref: EC:1.1.1.144
xref: MetaCyc:PERILLYL-ALCOHOL-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0459
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018458
name: isopiperitenol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-trans-isopiperitenol + NAD+ = (-)-isopiperitenone + NADH + H+." [EC:1.1.1.223]
synonym: "(-)-trans-isopiperitenol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.223]
xref: EC:1.1.1.223
xref: MetaCyc:ISOPIPERITENOL-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0468
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018459
name: carveol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-trans-carveol + NADP+ = (-)-carvone + NADPH + H+." [EC:1.1.1.243]
synonym: "(-)-trans-carveol dehydrogenase activity" EXACT [EC:1.1.1.243]
synonym: "(-)-trans-carveol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.243]
xref: EC:1.1.1.243
xref: MetaCyc:CARVEOL-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0446
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018460
name: cyclohexanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+." [EC:1.1.1.245]
synonym: "cyclohexanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.245]
xref: EC:1.1.1.245
xref: MetaCyc:CYCLOHEXANOL-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0165
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018461
name: fluoren-9-ol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+." [EC:1.1.1.256]
synonym: "9-fluorenol dehydrogenase activity" EXACT []
synonym: "fluoren-9-ol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.256]
xref: EC:1.1.1.256
xref: MetaCyc:9-FLUORENOL-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0292
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018462
name: 4-(hydroxymethyl)benzenesulfonate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD+ = 4-formylbenzenesulfonate + NADH + H+." [EC:1.1.1.257]
synonym: "4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.257]
synonym: "4-(hydroxymethyl)benzenesulphonate dehydrogenase activity" EXACT []
synonym: "4-sulfobenzyl alcohol dehydrogenase activity" EXACT []
xref: EC:1.1.1.257
xref: MetaCyc:1.1.1.257-RXN
xref: UM-BBD_enzymeID:e0239
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018463
name: 6-hydroxyhexanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxyhexanoate + NAD+ = 6-oxohexanoate + NADH + H+." [EC:1.1.1.258]
synonym: "6-hydroxyhexanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.258]
xref: EC:1.1.1.258
xref: MetaCyc:6-HYDROXYHEXANOATE-OXIDATION-RXN
xref: UM-BBD_enzymeID:e0168
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018464
name: 3-hydroxypimeloyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypimeloyl-CoA + NAD+ = 3-oxopimeloyl-CoA + NADH + H+." [EC:1.1.1.259]
synonym: "3-hydroxypimeloyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.259]
xref: EC:1.1.1.259
xref: MetaCyc:1.1.1.259-RXN
xref: UM-BBD_enzymeID:e0181
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018465
name: vanillyl-alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: vanillyl alcohol + O2 = vanillin + H2O2." [EC:1.1.3.38]
synonym: "4-hydroxy-2-methoxybenzyl alcohol oxidase activity" EXACT [EC:1.1.3.38]
synonym: "vanillyl alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.38]
xref: EC:1.1.3.38
xref: MetaCyc:1.1.3.38-RXN
xref: UM-BBD_enzymeID:e0404
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0018466
name: limonene-1,2-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene." [UM-BBD_enzymeID:e0463]
xref: EC:1.1.99.-
xref: UM-BBD_enzymeID:e0463
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0018467
name: formaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: formaldehyde + NAD+ + H2O = formate + NADH + H+. This enzyme does not need reduced glutathione." [EC:1.2.1.46]
subset: gosubset_prok
synonym: "formaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.46]
synonym: "glutathione-independent formaldehyde dehydrogenase activity" EXACT []
xref: EC:1.2.1.46
xref: MetaCyc:FORMALDEHYDE-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0120
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018468
name: alcohol dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: a primary alcohol + acceptor = an aldehyde + reduced acceptor." [EC:1.1.99.8]
subset: gosubset_prok
synonym: "alcohol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.8]
synonym: "alcohol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.8]
synonym: "MDH" RELATED [EC:1.1.99.8]
synonym: "PQQ-dependent alcohol dehydrogenase activity" EXACT []
synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.99.8]
synonym: "quinohemoprotein alcohol dehydrogenase activity" EXACT [EC:1.1.99.8]
synonym: "quinoprotein alcohol dehydrogenase activity" EXACT [EC:1.1.99.8]
synonym: "quinoprotein ethanol dehydrogenase activity" EXACT [EC:1.1.99.8]
xref: EC:1.1.99.8
xref: MetaCyc:ALCOHOL-DEHYDROGENASE-ACCEPTOR-RXN
xref: UM-BBD_enzymeID:e0004
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0018469
name: myrtenal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid." [UM-BBD_enzymeID:e0448]
xref: EC:1.2.-.-
xref: UM-BBD_enzymeID:e0448
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0018470
name: 4-hydroxybutaraldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate." [UM-BBD_enzymeID:e0018]
xref: EC:1.2.-.-
xref: UM-BBD_enzymeID:e0018
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0018471
name: 4-chlorobenzaldehyde oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-." [UM-BBD_enzymeID:e0316]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0316
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018472
name: 1-hydroxy-2-naphthaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate." [UM-BBD_enzymeID:e0328]
xref: EC:1.2.1.-
xref: UM-BBD_enzymeID:e0328
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018473
name: cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_enzymeID:e0472]
xref: EC:1.2.1.-
xref: UM-BBD_enzymeID:e0472
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018474
name: 2-carboxybenzaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-carboxybenzaldehyde + NAD+ + H2O = NADH + 2 H+ + phthalate." [UM-BBD_enzymeID:e0331]
xref: EC:1.2.1.-
xref: UM-BBD_enzymeID:e0331
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018475
name: trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_enzymeID:e0474]
xref: EC:1.2.1.-
xref: UM-BBD_enzymeID:e0474
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018477
name: benzaldehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+." [EC:1.2.1.7]
synonym: "benzaldehyde:NADP+ oxidoreductase" EXACT [EC:1.2.1.7]
synonym: "NADP-linked benzaldehyde dehydrogenase" EXACT [EC:1.2.1.7]
xref: EC:1.2.1.7
xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NADP+-RXN
xref: UM-BBD_enzymeID:e0079
is_a: GO:0019115 ! benzaldehyde dehydrogenase activity

[Term]
id: GO:0018478
name: malonate-semialdehyde dehydrogenase (acetylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+." [EC:1.2.1.18]
subset: gosubset_prok
synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating)" EXACT [EC:1.2.1.18]
synonym: "malonic semialdehyde oxidative decarboxylase activity" EXACT []
xref: EC:1.2.1.18
xref: MetaCyc:1.2.1.18-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018479
name: benzaldehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+." [EC:1.2.1.28]
subset: gosubset_prok
synonym: "benzaldehyde (NAD) dehydrogenase activity" EXACT [EC:1.2.1.28]
synonym: "benzaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.28]
xref: EC:1.2.1.28
xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NAD+-RXN
xref: UM-BBD_enzymeID:e0101
is_a: GO:0019115 ! benzaldehyde dehydrogenase activity

[Term]
id: GO:0018480
name: 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+." [EC:1.2.1.60]
subset: gosubset_prok
synonym: "5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.60]
synonym: "carboxymethylhydroxymuconic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.60]
xref: EC:1.2.1.60
xref: MetaCyc:CHMS-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0280
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018481
name: 4-hydroxymuconic-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxymuconic semialdehyde + NAD+ + H2O = maleylacetate + NADH + H+." [EC:1.2.1.61]
subset: gosubset_prok
synonym: "4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.61]
xref: EC:1.2.1.61
xref: MetaCyc:1.2.1.61-RXN
xref: UM-BBD_enzymeID:e0204
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018482
name: 4-formylbenzenesulfonate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-formylbenzenesulfonate + NAD+ + H2O = 4-sulfobenzoate + NADH + H+." [EC:1.2.1.62]
synonym: "4-formylbenzenesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.62]
synonym: "4-formylbenzenesulphonate dehydrogenase activity" EXACT []
synonym: "toluene-sulfonate aldehyde dehydrogenase activity" EXACT []
xref: EC:1.2.1.62
xref: MetaCyc:1.2.1.62-RXN
xref: UM-BBD_enzymeID:e0240
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018483
name: 6-oxohexanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+." [EC:1.2.1.63]
synonym: "6-oxohexanoate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.63]
xref: EC:1.2.1.63
xref: MetaCyc:6-OXOHEXANOATE-OXIDATION-RXN
xref: UM-BBD_enzymeID:e0171
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018484
name: 4-hydroxybenzaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+." [EC:1.2.1.64]
synonym: "3-hydroxybenzaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.64]
synonym: "p-hydroxybenzaldehyde dehydrogenase activity" EXACT [EC:1.2.1.64]
xref: EC:1.2.1.64
xref: MetaCyc:HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN
xref: UM-BBD_enzymeID:e0226
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018485
name: salicylaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+." [EC:1.2.1.65]
subset: gosubset_prok
synonym: "salicylaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.65]
xref: EC:1.2.1.65
xref: MetaCyc:1.2.1.65-RXN
xref: UM-BBD_enzymeID:e0256
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018486
name: 2-butanone oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate." [UM-BBD_enzymeID:e0053]
xref: EC:1.2.3.-
xref: UM-BBD_enzymeID:e0053
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0018487
name: vanillate O-demethylase (anaerobic) activity
namespace: molecular_function
def: "Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate." [UM-BBD_enzymeID:e0480]
xref: EC:1.2.3.-
xref: UM-BBD_enzymeID:e0480
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor
is_a: GO:0032451 ! demethylase activity

[Term]
id: GO:0018488
name: aryl-aldehyde oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + H2O2." [EC:1.2.3.9]
synonym: "aryl-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.9]
xref: EC:1.2.3.9
xref: MetaCyc:ARYL-ALDEHYDE-OXIDASE-RXN
xref: UM-BBD_enzymeID:e0116
is_a: GO:0004031 ! aldehyde oxidase activity

[Term]
id: GO:0018489
name: vanillate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: vanillate + O2 + NADH + H+ = 3,4-dihydroxybenzoate + NAD+ + H2O + formaldehyde." [EC:1.14.13.82]
comment: Note that this was EC:1.2.3.12.
subset: gosubset_prok
synonym: "4-hydroxy-3-methoxybenzoate demethylase activity" EXACT [EC:1.14.13.82]
synonym: "vanillate demethylase (aerobic) activity" EXACT []
synonym: "vanillate demethylase activity" EXACT []
synonym: "vanillate:oxygen oxidoreductase (demethylating)" EXACT [EC:1.14.13.82]
xref: EC:1.14.13.82
xref: MetaCyc:RXN-2
xref: UM-BBD_enzymeID:e0117
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
is_a: GO:0032451 ! demethylase activity

[Term]
id: GO:0018490
name: 4-hydroxyphenylpyruvate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + 1/2 O2 = 4-hydroxyphenylacetate + CO2." [EC:1.2.3.13]
synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.2.3.13]
xref: EC:1.2.3.13
xref: MetaCyc:1.2.3.13-RXN
xref: UM-BBD_enzymeID:e0244
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0018491
name: 2-oxobutyrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.2]
synonym: "2-ketobutyrate synthase activity" EXACT [EC:1.2.7.2]
synonym: "2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating)" EXACT [EC:1.2.7.2]
synonym: "2-oxobutyrate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.2]
synonym: "alpha-ketobutyrate synthase activity" EXACT [EC:1.2.7.2]
synonym: "alpha-ketobutyrate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.2]
xref: EC:1.2.7.2
xref: MetaCyc:2-OXOBUTYRATE-SYNTHASE-RXN
xref: UM-BBD_enzymeID:e0275
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018492
name: carbon-monoxide dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor." [EC:1.2.99.2]
subset: gosubset_prok
synonym: "anaerobic carbon monoxide dehydrogenase activity" EXACT [EC:1.2.99.2]
synonym: "carbon monoxide dehydrogenase activity" BROAD []
synonym: "carbon-monoxide:acceptor oxidoreductase activity" EXACT [EC:1.2.99.2]
xref: EC:1.2.99.2
xref: MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0415
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0018493
name: formylmethanofuran dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: formylmethanofuran + H2O + acceptor = CO2 + methanofuran + reduced acceptor." [EC:1.2.99.5]
subset: gosubset_prok
synonym: "formylmethanofuran:(acceptor) oxidoreductase activity" EXACT [EC:1.2.99.5]
synonym: "formylmethanofuran:acceptor oxidoreductase activity" EXACT [EC:1.2.99.5]
xref: EC:1.2.99.5
xref: MetaCyc:FORMYLMETHANOFURAN-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0121
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0018494
name: carvone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: carvone + 2 H+ + 2 e- = dihydrocarvone." [UM-BBD_enzymeID:e0473]
xref: EC:1.3.-.-
xref: MetaCyc:RXN-9403
xref: MetaCyc:RXN-9419
xref: UM-BBD_enzymeID:e0473
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018495
name: 2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA." [UM-BBD_enzymeID:e0177]
xref: EC:1.3.-.-
xref: UM-BBD_enzymeID:e0177
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018496
name: 2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_enzymeID:e0186]
xref: EC:1.3.-.-
xref: UM-BBD_enzymeID:e0186
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018497
name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS." [UM-BBD_enzymeID:e0352]
synonym: "DDMS dehydrogenase activity" EXACT []
xref: EC:1.3.-.-
xref: UM-BBD_enzymeID:e0352
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018498
name: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate." [UM-BBD_enzymeID:e0308]
xref: EC:1.3.1.-
xref: MetaCyc:PHENPRODIOLDEHYDROG-RXN
xref: UM-BBD_enzymeID:e0308
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018499
name: cis-2,3-dihydrodiol DDT dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT." [UM-BBD_enzymeID:e0320]
xref: EC:1.3.1.-
xref: UM-BBD_enzymeID:e0320
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018500
name: trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene." [UM-BBD_enzymeID:e0381]
xref: EC:1.3.1.-
xref: UM-BBD_enzymeID:e0381
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018501
name: cis-chlorobenzene dihydrodiol dehydrogenase activity
namespace: molecular_function
xref: EC:1.3.1.-
xref: UM-BBD_enzymeID:e0411
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018502
name: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone." [UM-BBD_enzymeID:e0362]
xref: EC:1.3.1.-
xref: MetaCyc:LINC-RXN
xref: UM-BBD_enzymeID:e0362
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018503
name: trans-1,2-dihydrodiolphenanthrene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene." [UM-BBD_enzymeID:e0380]
xref: EC:1.3.1.-
xref: UM-BBD_enzymeID:e0380
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018504
name: cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+." [EC:1.3.1.19]
subset: gosubset_prok
synonym: "cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.19]
synonym: "cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase activity" EXACT [EC:1.3.1.19]
synonym: "cis-benzene glycol dehydrogenase activity" EXACT [EC:1.3.1.19]
xref: EC:1.3.1.19
xref: MetaCyc:1.3.1.19-RXN
xref: UM-BBD_enzymeID:e0060
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018505
name: cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+." [EC:1.3.1.29]
synonym: "(+)-cis-naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29]
synonym: "1,2-dihydroxy-1,2-dihydroxynaphthalene dehydrogenase activity" EXACT []
synonym: "cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase activity" EXACT [EC:1.3.1.29]
synonym: "cis-dihydrodiol naphthalene dehydrogenase activity" EXACT [EC:1.3.1.29]
synonym: "cis-naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29]
synonym: "naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29]
xref: EC:1.3.1.29
xref: MetaCyc:1.3.1.29-RXN
xref: UM-BBD_enzymeID:e0122
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018506
name: maleylacetate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+." [EC:1.3.1.32]
subset: gosubset_prok
synonym: "3-oxoadipate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.32]
synonym: "maleolylacetate reductase activity" EXACT [EC:1.3.1.32]
xref: EC:1.3.1.32
xref: MetaCyc:MALEYLACETATE-REDUCTASE-RXN
xref: UM-BBD_enzymeID:e0063
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018507
name: cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-cis-3,4-dihydrophenanthrene-3,4-diol + NAD+ = phenanthrene-3,4-diol + NADH + H+." [EC:1.3.1.49]
synonym: "(+)-cis-3,4-dihydrophenanthrene-3,4-diol:NAD+ 3,4-oxidoreductase activity" EXACT [EC:1.3.1.49]
synonym: "cis-3,4-dihydroxy-3,4-dihydrophenanthrene dehydrogenase activity" EXACT []
xref: EC:1.3.1.49
xref: MetaCyc:1.3.1.49-RXN
xref: UM-BBD_enzymeID:e0322
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018508
name: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+." [MetaCyc:BENZOATE-CIS-DIOL-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "benzoate cis-diol dehydrogenase activity" EXACT []
xref: UM-BBD_enzymeID:e0219
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018509
name: cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+." [EC:1.3.1.56]
subset: gosubset_prok
synonym: "2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase activity" EXACT []
synonym: "biphenyl-2,3-dihydro-2,3-diol dehydrogenase activity" EXACT [EC:1.3.1.56]
synonym: "cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.56]
xref: EC:1.3.1.56
xref: MetaCyc:1.3.1.56-RXN
xref: UM-BBD_enzymeID:e0134
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018510
name: phloroglucinol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrophloroglucinol + NADP+ = phloroglucinol + NADPH + H+." [EC:1.3.1.57]
subset: gosubset_prok
synonym: "dihydrophloroglucinol:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.57]
xref: EC:1.3.1.57
xref: MetaCyc:R5-RXN
xref: UM-BBD_enzymeID:e0010
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018511
name: 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate + NAD+ = 2,3-dihydroxy-p-cumate + NADH + H+." [EC:1.3.1.58]
subset: gosubset_prok
synonym: "cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.58]
xref: EC:1.3.1.58
xref: MetaCyc:RXN-665
xref: UM-BBD_enzymeID:e0284
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018512
name: 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH + H+." [EC:1.3.1.59]
comment: This term was made obsolete because, according to the Enzyme Commission, there is no evidence that this enzymatic activity exists.
synonym: "1,2-dihydroxy-3-methylcyclohexa-3,5-diene-carboxylate dehydrogenase activity" EXACT []
xref: EC:1.3.1.59
xref: UM-BBD_enzymeID:e0191
is_obsolete: true

[Term]
id: GO:0018513
name: dibenzothiophene dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD+ = 1,2-dihydroxydibenzothiophene + NADH + H+." [EC:1.3.1.60]
subset: gosubset_prok
synonym: "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.60]
xref: EC:1.3.1.60
xref: MetaCyc:1.3.1.60-RXN
xref: UM-BBD_enzymeID:e0161
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018515
name: pimeloyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pimeloyl-CoA + NAD+ = 6-carboxyhex-2-enoyl-CoA + NADH + H+." [EC:1.3.1.62]
subset: gosubset_prok
synonym: "pimeloyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.62]
xref: EC:1.3.1.62
xref: MetaCyc:1.3.1.62-RXN
xref: UM-BBD_enzymeID:e0179
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018516
name: 2,4-dichlorobenzoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + NADP+ + HCl = 2,4-dichlorobenzoyl-CoA + NADPH + H+." [EC:1.3.1.63]
synonym: "4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating)" EXACT [EC:1.3.1.63]
xref: EC:1.3.1.63
xref: MetaCyc:1.3.1.63-RXN
xref: UM-BBD_enzymeID:e0111
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018517
name: phthalate 4,5-cis-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ = 4,5-dihydroxyphthalate + NADH + H+." [EC:1.3.1.64]
synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.64]
xref: EC:1.3.1.64
xref: MetaCyc:1.3.1.64-RXN
xref: UM-BBD_enzymeID:e0105
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018518
name: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline + NAD+ = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + NADH + H+." [EC:1.3.1.65]
synonym: "5,6-dihydrodiol-3-methyl-2-oxo-1,2-dihydroquinoline dehydrogenase" RELATED []
synonym: "5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.65]
xref: EC:1.3.1.65
xref: MetaCyc:RXN-643
xref: UM-BBD_enzymeID:e0047
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018519
name: cis-dihydroethylcatechol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD+ = 3-ethylcatechol + NADH + H+." [EC:1.3.1.66]
synonym: "cis-1,2-dihydro-3-ethylcatechol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.66]
synonym: "cis-ethylbenzene glycol dehydrogenase activity" EXACT []
xref: EC:1.3.1.66
xref: MetaCyc:1.3.1.66-RXN
xref: UM-BBD_enzymeID:e0218
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018520
name: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2." [EC:1.3.1.67]
synonym: "4-methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid dehydrogenase activity" EXACT []
synonym: "cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.67]
xref: EC:1.3.1.67
xref: MetaCyc:1.3.1.67-RXN
xref: UM-BBD_enzymeID:e0173
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018521
name: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate + NAD+ = 3-methylcatechol + NADH + H+ + CO2." [EC:1.3.1.68]
synonym: "1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.68]
xref: EC:1.3.1.68
xref: MetaCyc:1.3.1.68-RXN
xref: UM-BBD_enzymeID:e0194
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018522
name: benzoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoyl-CoA + donor-H2 + 2 ATP = cyclohexa-1,5-diene-1-carbonyl-CoA + acceptor + 2 ADP + 2 phosphate." [EC:1.3.99.15]
subset: gosubset_prok
synonym: "benzoyl-CoA reductase (dearomatizing) activity" EXACT [EC:1.3.99.15]
synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA:acceptor oxidoreductase (aromatizing, ATP-forming)" EXACT [EC:1.3.99.15]
xref: EC:1.3.99.15
xref: MetaCyc:1.3.99.15-RXN
xref: UM-BBD_enzymeID:e0176
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0018523
name: quinoline 2-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor." [EC:1.3.99.17]
subset: gosubset_prok
synonym: "quinoline:acceptor 2-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.17]
xref: EC:1.3.99.17
xref: MetaCyc:1.3.99.17-RXN
xref: UM-BBD_enzymeID:e0041
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0018524
name: acetophenone carboxylase activity
namespace: molecular_function
alt_id: GO:0018797
def: "Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate." [UM-BBD_enzymeID:e0211]
xref: EC:6.4.1.-
xref: UM-BBD_enzymeID:e0211
is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds

[Term]
id: GO:0018525
name: 4-hydroxybenzoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoyl-CoA + acceptor = benzoyl-CoA + reduced acceptor." [EC:1.3.99.20]
subset: gosubset_prok
synonym: "4-hydroxybenzoyl-CoA reductase (dehydroxylating) activity" EXACT [EC:1.3.99.20]
synonym: "4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.20]
synonym: "4-hydroxybenzoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.20]
xref: EC:1.3.99.20
xref: MetaCyc:1.3.99.20-RXN
xref: UM-BBD_enzymeID:e0159
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0018526
name: 2-aminobenzoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA." [UM-BBD_enzymeID:e0263]
xref: EC:1.4.-.-
xref: UM-BBD_enzymeID:e0263
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0018527
name: cyclohexylamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + H2O2." [EC:1.4.3.12]
synonym: "cyclohexylamine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.12]
xref: EC:1.4.3.12
xref: MetaCyc:CYCLOHEXYLAMINE-OXIDASE-RXN
xref: UM-BBD_enzymeID:e0477
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0018528
name: iminodiacetate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine." [UM-BBD_enzymeID:e0390]
xref: EC:1.5.-.-
xref: UM-BBD_enzymeID:e0390
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0018529
name: nitrilotriacetate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrilotriacetate + NADH + H+ + O2 = NAD+ + H2O + glyoxylate + iminodiacetate." [UM-BBD_enzymeID:e0388]
xref: EC:1.5.1.-
xref: UM-BBD_enzymeID:e0388
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0018530
name: (R)-6-hydroxynicotine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2." [EC:1.5.3.6]
subset: gosubset_prok
synonym: "(R)-6-hydroxynicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.6]
synonym: "6-hydroxy-D-nicotine oxidase activity" EXACT []
synonym: "D-6-hydroxynicotine oxidase activity" EXACT [EC:1.5.3.6]
xref: EC:1.5.3.6
xref: MetaCyc:R-6-HYDROXYNICOTINE-OXIDASE-RXN
xref: UM-BBD_enzymeID:e0338
is_a: GO:0019116 ! hydroxy-nicotine oxidase activity

[Term]
id: GO:0018531
name: (S)-6-hydroxynicotine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2." [EC:1.5.3.5]
subset: gosubset_prok
synonym: "(S)-6-hydroxynicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.5]
synonym: "6-hydroxy-L-nicotine oxidase activity" EXACT []
synonym: "6-hydroxy-L-nicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.5]
synonym: "L-6-hydroxynicotine oxidase activity" EXACT []
xref: EC:1.5.3.5
xref: MetaCyc:S-6-HYDROXYNICOTINE-OXIDASE-RXN
xref: UM-BBD_enzymeID:e0339
is_a: GO:0019116 ! hydroxy-nicotine oxidase activity

[Term]
id: GO:0018532
name: F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin." [UM-BBD_enzymeID:e0265, UM-BBD_reactionID:r0353]
synonym: "F420-independent methylene-H4MPT dehydrogenase activity" EXACT []
xref: EC:1.5.99.-
xref: UM-BBD_enzymeID:e0265
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0018533
name: peptidyl-cysteine acetylation
namespace: biological_process
def: "The acetylation of peptidyl-cysteine." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006473 ! protein amino acid acetylation
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0018534
name: nitrilotriacetate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrilotriacetate + OH- = H+ + 2 e- + glyoxylate + iminodiacetate." [UM-BBD_enzymeID:e0389]
xref: EC:1.5.99.-
xref: UM-BBD_enzymeID:e0389
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0018535
name: nicotine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor." [EC:1.5.99.4]
subset: gosubset_prok
synonym: "D-nicotine oxidase activity" EXACT [EC:1.5.99.4]
synonym: "nicotine oxidase activity" EXACT [EC:1.5.99.4]
synonym: "nicotine:(acceptor) 6-oxidoreductase (hydroxylating)" EXACT [EC:1.5.99.4]
synonym: "nicotine:acceptor 6-oxidoreductase (hydroxylating)" EXACT [EC:1.5.99.4]
xref: EC:1.5.99.4
xref: MetaCyc:NICOTINE-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0337
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0018537
name: coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: N5,N10-methylenetetrahydromethanopterin + reduced coenzyme F420 = 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme F420." [EC:1.5.99.11]
subset: gosubset_prok
synonym: "5,10-methylenetetrahydromethanopterin cyclohydrolase activity" EXACT [EC:1.5.99.11]
synonym: "5,10-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11]
synonym: "5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11]
synonym: "coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11]
synonym: "methylene-H(4)MPT reductase activity" EXACT [EC:1.5.99.11]
synonym: "methylene-H4MPT reductase activity" EXACT [EC:1.5.99.11]
synonym: "methylenetetrahydromethanopterin reductase activity" EXACT []
synonym: "N(5),N(10)-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11]
synonym: "N(5),N(10)-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11]
synonym: "N5,N10-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11]
synonym: "N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11]
xref: EC:1.5.99.11
xref: MetaCyc:METHELENE-THMPT-OXI-RXN
xref: UM-BBD_enzymeID:e0266
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0018538
name: epoxide carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ring opening and carboxylation of an epoxide; the reaction requires CO2 as a cosubstrate and forms a beta-keto acid as a products. An example of such a reaction is: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+." [PMID:9555888]
xref: EC:1.6.-.-
is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH

[Term]
id: GO:0018541
name: p-benzoquinone reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H+ + p-benzoquinone = NADP+ + hydroquinone." [EC:1.6.5.6]
synonym: "NADPH:p-benzoquinone oxidoreductase activity" EXACT [EC:1.6.5.6]
xref: EC:1.6.5.6
xref: MetaCyc:1.6.5.6-RXN
xref: UM-BBD_enzymeID:e0422
is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor

[Term]
id: GO:0018542
name: 2,3-dihydroxy DDT 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate." [UM-BBD_enzymeID:e0315]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0315
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018543
name: 4-amino-2-nitroso-6-nitrotoluene reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene." [UM-BBD_enzymeID:e0365]
xref: EC:1.6.6.-
xref: UM-BBD_enzymeID:e0365
is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor

[Term]
id: GO:0018544
name: 4-carboxy-4'-sulfoazobenzene reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate." [UM-BBD_enzymeID:e0391]
synonym: "4-carboxy-4'-sulphoazobenzene reductase activity" EXACT []
xref: EC:1.6.6.-
xref: UM-BBD_enzymeID:e0391
is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor

[Term]
id: GO:0018545
name: NAD(P)H nitroreductase activity
namespace: molecular_function
xref: EC:1.6.6.-
xref: UM-BBD_enzymeID:e0346
is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor

[Term]
id: GO:0018546
name: nitrobenzene nitroreductase activity
namespace: molecular_function
xref: EC:1.6.6.-
xref: UM-BBD_enzymeID:e0245
is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor

[Term]
id: GO:0018547
name: nitroglycerin reductase activity
namespace: molecular_function
def: "Catalysis of the removal of one or more nitrite (NO2(-)) groups from nitroglycerin or a derivative." [UM-BBD_enzymeID:e0038]
synonym: "NG reductase activity" EXACT []
xref: EC:1.7.3.-
xref: UM-BBD_enzymeID:e0038
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

[Term]
id: GO:0018548
name: pentaerythritol tetranitrate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: pentaerythritol tri(or tetra)nitrate + NADPH = NADP+ + NO3- (nitrate) + pentaerythritol di(or tri)nitrate." [UM-BBD_enzymeID:e0035]
xref: EC:1.7.99.-
xref: UM-BBD_enzymeID:e0035
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0018549
name: methanethiol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + H2O2." [EC:1.8.3.4]
synonym: "(MM)-oxidase activity" EXACT [EC:1.8.3.4]
synonym: "methanethiol:oxygen oxidoreductase activity" EXACT [EC:1.8.3.4]
synonym: "methyl mercaptan oxidase activity" EXACT [EC:1.8.3.4]
synonym: "methylmercaptan oxidase activity" EXACT [EC:1.8.3.4]
synonym: "MT-oxidase activity" EXACT [EC:1.8.3.4]
xref: EC:1.8.3.4
xref: MetaCyc:METHANETHIOL-OXIDASE-RXN
xref: UM-BBD_enzymeID:e0153
is_a: GO:0016670 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0018550
name: tetrachloro-p-hyrodoquinone reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: organohalide + 2 GSH = GSSG + HCl + RH. Substrates are 2,3,5,6-tetrachlorohydroquinone (TeCH) (forms 2,3,6-trichlorohydroquinone (TrCH)) and 2,3,6-trichlorohydroquinone (TrCH) (forms 2,6-dichlorohydroquinone (DiCH))." [UM-BBD_enzymeID:e0251]
xref: EC:1.8.99.-
xref: UM-BBD_enzymeID:e0251
is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors

[Term]
id: GO:0018551
name: hydrogensulfite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: O3S-S-SO3(2-) + acceptor + 2 H2O + OH- = 3 HSO3(-) + reduced acceptor." [EC:1.8.99.3]
subset: gosubset_prok
synonym: "bisulfite reductase activity" EXACT [EC:1.8.99.3]
synonym: "desulfofuscidin activity" NARROW [EC:1.8.99.3]
synonym: "desulforubidin activity" NARROW [EC:1.8.99.3]
synonym: "desulfoviridin activity" NARROW [EC:1.8.99.3]
synonym: "dissimilatory sulfite reductase activity" EXACT []
synonym: "dissimilatory-type sulfite reductase activity" EXACT [EC:1.8.99.3]
synonym: "hydrogensulphite reductase activity" EXACT []
synonym: "trithionate:(acceptor) oxidoreductase activity" EXACT [EC:1.8.99.3]
synonym: "trithionate:acceptor oxidoreductase activity" EXACT [EC:1.8.99.3]
xref: EC:1.8.99.3
xref: MetaCyc:HYDROGENSULFITE-REDUCTASE-RXN
xref: UM-BBD_enzymeID:e0416
is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors

[Term]
id: GO:0018552
name: methyl-coenzyme-M reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: methyl-coenzyme-M + HTP = CoM-S-S-HTP + methane." [UM-BBD_enzymeID:e0267]
xref: EC:1.12.99.-
xref: MetaCyc:METHYL-COM-HTP-RXN
xref: UM-BBD_enzymeID:e0267
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0018553
name: 3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate." [UM-BBD_enzymeID:e0309]
xref: EC:1.13.-.-
xref: UM-BBD_enzymeID:e0309
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0018554
name: 1,2-dihydroxynaphthalene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached." [UM-BBD_enzymeID:e0255]
xref: EC:1.13.-.-
xref: UM-BBD_enzymeID:e0255
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0018555
name: phenanthrene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ = cis-3,4-dihydroxy-3,4-dihydrophenanthrene." [UM-BBD_enzymeID:e0321]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0321
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018556
name: 2,2',3-trihydroxybiphenyl dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate)." [UM-BBD_enzymeID:e0032]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0032
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018557
name: 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid." [UM-BBD_enzymeID:e0295]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0295
is_a: GO:0019117 ! dihydroxyfluorene dioxygenase activity

[Term]
id: GO:0018558
name: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon." [UM-BBD_enzymeID:e0044]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0044
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018559
name: 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate." [UM-BBD_enzymeID:e0313]
synonym: "1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethylene 1,2-dioxygenase activity" EXACT []
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0313
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018560
name: protocatechuate 3,4-dioxygenase type II activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate." [UM-BBD_enzymeID:e0385]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0385
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018561
name: 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate." [UM-BBD_enzymeID:e0324]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0324
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018562
name: 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid." [UM-BBD_enzymeID:e0294]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0294
is_a: GO:0019117 ! dihydroxyfluorene dioxygenase activity

[Term]
id: GO:0018563
name: 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate." [UM-BBD_enzymeID:e0220]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0220
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018564
name: carbazole 1,9a-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol." [UM-BBD_enzymeID:e0323]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0323
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018565
name: dihydroxydibenzothiophene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_enzymeID:e0162]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0162
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018566
name: 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate." [UM-BBD_enzymeID:e0250]
synonym: "1,2-dihydroxynaphthalene-6-sulphonate 1,8a-dioxygenase activity" EXACT []
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0250
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018567
name: styrene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol." [UM-BBD_enzymeID:e0200]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0200
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018568
name: 3,4-dihydroxyphenanthrene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate." [UM-BBD_enzymeID:e0345]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0345
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018569
name: hydroquinone 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde." [UM-BBD_enzymeID:e0203]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0203
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018570
name: p-cumate 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate." [UM-BBD_enzymeID:e0270]
xref: EC:1.13.11.-
xref: MetaCyc:RXN-664
xref: UM-BBD_enzymeID:e0270
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018571
name: 2,3-dihydroxy-p-cumate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate." [MetaCyc:RXN-666, UM-BBD_enzymeID:e0285]
subset: gosubset_prok
synonym: "2,3-dihydroxy-p-cumate 3,4-dioxygenase" EXACT []
synonym: "2,3-dihydroxy-p-cumate-3,4-dioxygenase" EXACT []
xref: EC:1.13.11.-
xref: MetaCyc:RXN-666
xref: UM-BBD_enzymeID:e0285
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018572
name: 3,5-dichlorocatechol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H + 2,4-dichloro-cis,cis-muconate." [UM-BBD_enzymeID:e0231]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0231
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018573
name: 2-aminophenol 1,6-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde." [UM-BBD_enzymeID:e0247]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0247
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018574
name: 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate." [UM-BBD_enzymeID:e0422]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0422
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018575
name: chlorocatechol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate." [UM-BBD_enzymeID:e0419]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0419
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018576
name: catechol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: catechol + O2 = cis,cis-muconate." [EC:1.13.11.1]
subset: gosubset_prok
synonym: "1,2-pyrocatechase activity" EXACT [EC:1.13.11.1]
synonym: "catechase activity" RELATED [EC:1.13.11.1]
synonym: "catechol 1,2-oxygenase activity" EXACT [EC:1.13.11.1]
synonym: "catechol-oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.1]
synonym: "catechol:oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.1]
synonym: "CD I" RELATED [EC:1.13.11.1]
synonym: "CD II" RELATED [EC:1.13.11.1]
synonym: "pyrocatechase activity" RELATED [EC:1.13.11.1]
synonym: "pyrocatechol 1,2-dioxygenase activity" EXACT [EC:1.13.11.1]
xref: EC:1.13.11.1
xref: MetaCyc:CATECHOL-12-DIOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0064
is_a: GO:0019114 ! catechol dioxygenase activity

[Term]
id: GO:0018577
name: catechol 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde." [EC:1.13.11.2]
subset: gosubset_prok
synonym: "2,3-pyrocatechase activity" EXACT [EC:1.13.11.2]
synonym: "catechol 2,3-oxygenase" EXACT [EC:1.13.11.2]
synonym: "catechol oxygenase" EXACT [EC:1.13.11.2]
synonym: "catechol:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.2]
synonym: "cato2ase activity" RELATED [EC:1.13.11.2]
synonym: "metapyrocatechase activity" RELATED [EC:1.13.11.2]
synonym: "pyrocatechol 2,3-dioxygenase" EXACT [EC:1.13.11.2]
xref: EC:1.13.11.2
xref: MetaCyc:CATECHOL-23-DIOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0156
is_a: GO:0019114 ! catechol dioxygenase activity

[Term]
id: GO:0018578
name: protocatechuate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate." [EC:1.13.11.3]
subset: gosubset_prok
synonym: "protocatechuate oxygenase activity" BROAD [EC:1.13.11.3]
synonym: "protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.3]
synonym: "protocatechuic 3,4-dioxygenase activity" EXACT [EC:1.13.11.3]
synonym: "protocatechuic 3,4-oxygenase activity" EXACT [EC:1.13.11.3]
synonym: "protocatechuic acid oxidase activity" EXACT [EC:1.13.11.3]
xref: EC:1.13.11.3
xref: MetaCyc:PROTOCATECHUATE-34-DIOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0114
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018579
name: protocatechuate 4,5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde." [EC:1.13.11.8]
subset: gosubset_prok
synonym: "protocatechuate 4,5-oxygenase activity" EXACT [EC:1.13.11.8]
synonym: "protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.8]
synonym: "protocatechuic 4,5-dioxygenase activity" EXACT [EC:1.13.11.8]
synonym: "protocatechuic 4,5-oxygenase activity" EXACT [EC:1.13.11.8]
xref: EC:1.13.11.8
xref: MetaCyc:PROTOCATECHUATE-45-DIOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0115
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018580
name: 2-nitropropane dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 2-nitropropane + O2 = 2 acetone + 2 NO2(-) (nitrite)." [EC:1.13.11.32]
subset: gosubset_prok
synonym: "2-nitropropane:oxygen 2-oxidoreductase activity" EXACT [EC:1.13.11.32]
synonym: "2-NPD activity" EXACT [EC:1.13.11.32]
synonym: "nitroalkane oxidase activity" EXACT [EC:1.13.11.32]
xref: EC:1.13.11.32
xref: MetaCyc:2-NITROPROPANE-DIOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0387
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018581
name: hydroxyquinol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate." [EC:1.13.11.37]
subset: gosubset_prok
synonym: "benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.37]
synonym: "hydroxyquinol dioxygenase activity" EXACT [EC:1.13.11.37]
xref: EC:1.13.11.37
xref: MetaCyc:HYDROXYQUINOL-12-DIOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0207
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018582
name: 1-hydroxy-2-naphthoate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate." [EC:1.13.11.38]
synonym: "1-hydroxy-2-naphthoate dioxygenase activity" EXACT []
synonym: "1-hydroxy-2-naphthoate-degrading enzyme activity" NARROW [EC:1.13.11.38]
synonym: "1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.38]
synonym: "1-hydroxy-2-naphthoic acid dioxygenase activity" EXACT [EC:1.13.11.38]
xref: EC:1.13.11.38
xref: MetaCyc:1.13.11.38-RXN
xref: UM-BBD_enzymeID:e0329
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018583
name: biphenyl-2,3-diol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O." [EC:1.13.11.39]
subset: gosubset_prok
synonym: "2,3-dihydroxybiphenyl 1,2-dioxygenase activity" BROAD []
synonym: "2,3-dihydroxybiphenyl dioxygenase activity" BROAD [EC:1.13.11.39]
synonym: "biphenyl-2,3-diol dioxygenase activity" EXACT [EC:1.13.11.39]
synonym: "biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.39]
xref: EC:1.13.11.39
xref: MetaCyc:BIPHENYL-23-DIOL-12-DIOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0127
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0018584
name: 2,4,5-trichlorophenoxyacetic acid oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol." [UM-BBD_enzymeID:e0276]
xref: EC:1.13.99.-
xref: UM-BBD_enzymeID:e0276
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0018585
name: fluorene oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol." [UM-BBD_enzymeID:e0291]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0291
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018586
name: mono-butyltin dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: butyltin (MBT) + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin." [UM-BBD_enzymeID:e0407]
synonym: "MBT dioxygenase activity" EXACT []
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0407
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018587
name: limonene 8-monooxygenase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0466
is_obsolete: true
replaced_by: GO:0019113

[Term]
id: GO:0018588
name: tri-n-butyltin dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tri-n-butyltin (TBT) + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin." [UM-BBD_enzymeID:e0349]
synonym: "TBT dioxygenase activity" EXACT []
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0349
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018589
name: di-n-butyltin dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dibutyltin (DBT) + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin." [UM-BBD_enzymeID:e0360]
synonym: "DBT dioxygenase activity" EXACT []
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0360
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018590
name: methylsilanetriol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol." [UM-BBD_enzymeID:e0343]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0343
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018591
name: methyl tertiary butyl ether 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde." [UM-BBD_reactionID:r1023]
synonym: "MTBE 3-monooxygenase activity" EXACT []
xref: EC:1.14.-.-
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018592
name: 4-nitrocatechol 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + NO2(-) (nitrite) + 1,2,4-benzenetriol." [UM-BBD_enzymeID:e0206]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0206
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018593
name: 4-chlorophenoxyacetate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol." [UM-BBD_enzymeID:e0234]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0234
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018594
name: tert-butyl alcohol 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tert-butyl alcohol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol." [UM-BBD_reactionID:r0615]
xref: EC:1.14.-.-
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018595
name: alpha-pinene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol." [UM-BBD_enzymeID:e0475]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0475
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018596
name: dimethylsilanediol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol." [UM-BBD_enzymeID:e0288]
synonym: "DMSD hydroxylase activity" EXACT []
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0288
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018597
name: ammonia monooxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidation of alkanes (up to C8) to alcohols and alkenes (up to C5) to epoxides and alcohols in the presence of ammonium ions." [PMID:16347810]
subset: gosubset_prok
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0061
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018598
name: hydroxymethylsilanetriol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol." [UM-BBD_enzymeID:e0348]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0348
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018599
name: 2-hydroxyisobutyrate 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate." [UM-BBD_enzymeID:e0410]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0410
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018600
name: alpha-pinene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol." [UM-BBD_enzymeID:e0441]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0441
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018601
name: 4-nitrophenol 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: p-nitrophenol + O2 + NADH + H+ = H2O + 4-nitrocatechol + NAD+." [EC:1.14.13.29, UM-BBD_enzymeID:e0205]
synonym: "4-nitrophenol hydroxylase activity" EXACT [EC:1.14.13.29]
synonym: "4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.29]
synonym: "4-nitrophenol-2-hydroxylase activity" EXACT [EC:1.14.13.29]
xref: EC:1.14.13.29
xref: MetaCyc:4-NITROPHENOL-2-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0205
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018602
name: 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid = glyoxylate + 2,4-dichlorophenol." [UM-BBD_enzymeID:e0230]
xref: EC:1.14.11.-
xref: MetaCyc:RXN-9863
xref: UM-BBD_enzymeID:e0230
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0018603
name: nitrobenzene 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + NO2(-) (nitrite) + catechol." [UM-BBD_enzymeID:e0248]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0248
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018604
name: 4-aminobenzoate 3,4-dioxygenase (deaminating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate." [UM-BBD_enzymeID:e0392]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0392
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018605
name: 2-aminobenzenesulfonate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-aminobenzenesulfonate + NADH + H+ + O2 = NAD+ + NH3 + 3-sulfocatechol." [PMID:10589735]
synonym: "2-aminobenzenesulphonate dioxygenase activity" EXACT []
xref: EC:1.14.12.-
xref: MetaCyc:2ASDOSALCAL-RXN
xref: UM-BBD_enzymeID:e0241
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018606
name: benzenesulfonate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol." [UM-BBD_enzymeID:e0242]
synonym: "benzenesulphonate dioxygenase activity" EXACT []
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0242
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018607
name: 1-indanone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin." [UM-BBD_enzymeID:e0298]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0298
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018608
name: 1-indanone dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone." [UM-BBD_enzymeID:e0296]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0296
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018609
name: chlorobenzene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene)." [UM-BBD_enzymeID:e0062]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0062
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018610
name: dibenzofuran 4,4a-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+." [MetaCyc:R606-RXN]
xref: EC:1.14.12.-
xref: MetaCyc:R606-RXN
xref: UM-BBD_enzymeID:e0030
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018611
name: toluate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate." [UM-BBD_enzymeID:e0190]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0190
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018612
name: dibenzothiophene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene." [UM-BBD_enzymeID:e0160]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0160
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018613
name: 9-fluorenone dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone." [UM-BBD_enzymeID:e0293]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0293
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018614
name: ethylbenzene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene." [UM-BBD_enzymeID:e0217]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0217
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018615
name: 2-indanone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone." [UM-BBD_enzymeID:e0299]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0299
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018616
name: trihydroxytoluene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate." [MetaCyc:R305-RXN, UM-BBD_enzymeID:e0074]
xref: EC:1.14.12.-
xref: MetaCyc:R305-RXN
xref: UM-BBD_enzymeID:e0074
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018617
name: 4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol." [UM-BBD_enzymeID:e0393]
synonym: "4-aminobenzenesulphonate 3,4-dioxygenase (deaminating) activity" EXACT []
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0393
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018618
name: anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3." [EC:1.14.12.1]
subset: gosubset_prok
synonym: "AntA" RELATED []
synonym: "AntB" RELATED []
synonym: "AntC" RELATED []
synonym: "anthranilate 1,2-dioxygenase" RELATED []
synonym: "anthranilate dioxygenase activity" EXACT []
synonym: "anthranilate dioxygenase reductase" NARROW []
synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.12.1]
synonym: "anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)" EXACT [EC:1.14.12.1]
synonym: "anthranilic acid hydroxylase activity" BROAD [EC:1.14.12.1]
synonym: "anthranilic hydroxylase activity" BROAD [EC:1.14.12.1]
xref: EC:1.14.12.1
xref: MetaCyc:1.14.12.1-RXN
xref: UM-BBD_enzymeID:e0371
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018619
name: benzene 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzene + NADH + H+ + O2 = cis-cyclohexa-3,5-diene-1,2-diol + NAD+." [EC:1.14.12.3]
subset: gosubset_prok
synonym: "benzene dioxygenase activity" EXACT [EC:1.14.12.3]
synonym: "benzene hydroxylase activity" RELATED [EC:1.14.12.3]
synonym: "benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.3]
xref: EC:1.14.12.3
xref: MetaCyc:BENZENE-12-DIOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0059
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018620
name: phthalate 4,5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phthalate + NADH + H+ + O2 = cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+." [EC:1.14.12.7]
subset: gosubset_prok
synonym: "PDO activity" EXACT [EC:1.14.12.7]
synonym: "phthalate dioxygenase activity" BROAD [EC:1.14.12.7]
synonym: "phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)" EXACT [EC:1.14.12.7]
xref: EC:1.14.12.7
xref: MetaCyc:PHTHALATE-45-DIOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0104
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018621
name: 4-sulfobenzoate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-sulfobenzoate + NADH + H+ + O2 = 3,4-dihydroxybenzoate + SO3(2-) (sulfite) + NAD+." [EC:1.14.12.8]
synonym: "4-sulfobenzoate 3,4-dioxygenase system" RELATED [EC:1.14.12.8]
synonym: "4-sulfobenzoate dioxygenase activity" EXACT [EC:1.14.12.8]
synonym: "4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)" EXACT [EC:1.14.12.8]
synonym: "4-sulphobenzoate 3,4-dioxygenase activity" EXACT []
xref: EC:1.14.12.8
xref: MetaCyc:4-SULFOBENZOATE-34-DIOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0128
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018622
name: 4-chlorophenylacetate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorophenyl acetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD+." [EC:1.14.12.9]
synonym: "4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating)" EXACT [EC:1.14.12.9]
xref: EC:1.14.12.9
xref: MetaCyc:1.14.12.9-RXN
xref: UM-BBD_enzymeID:e0290
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018623
name: benzoate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+." [EC:1.14.12.10]
subset: gosubset_prok
synonym: "benzoate dioxygenase activity" EXACT [EC:1.14.12.10]
synonym: "benzoate hydroxylase activity" EXACT [EC:1.14.12.10]
synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.10]
synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, decarboxylating)" EXACT [EC:1.14.12.10]
synonym: "benzoic hydroxylase activity" EXACT [EC:1.14.12.10]
xref: EC:1.14.12.10
xref: MetaCyc:BENZOATE-12-DIOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0154
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018624
name: toluene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene + NADH + H+ + O2 = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD+." [EC:1.14.12.11]
synonym: "toluene 1,2-dioxygenase activity" EXACT [EC:1.14.12.11]
synonym: "toluene 2,3-dioxygenase activity" EXACT [EC:1.14.12.11]
synonym: "toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.11]
xref: EC:1.14.12.11
xref: MetaCyc:TOLUENE-DIOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0155
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018625
name: naphthalene 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+." [EC:1.14.12.12]
subset: gosubset_prok
synonym: "naphthalene dioxygenase activity" EXACT [EC:1.14.12.12]
synonym: "naphthalene oxygenase activity" EXACT [EC:1.14.12.12]
synonym: "naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.12]
xref: EC:1.14.12.12
xref: MetaCyc:NAPHTHALENE-12-DIOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0002
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018626
name: 2-chlorobenzoate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2." [EC:1.14.12.13]
subset: gosubset_prok
synonym: "2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating)" EXACT [EC:1.14.12.13]
synonym: "2-halobenzoate 1,2-dioxygenase activity" EXACT []
xref: EC:1.14.12.13
xref: MetaCyc:2-CHLOROBENZOATE-12-DIOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0036
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018627
name: 2-aminobenzenesulfonate 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-aminobenzenesulfonate + NADH + H+ + O2 = 2,3-dihydroxybenzenesulfonate + NH3 + NAD+." [EC:1.14.12.14]
synonym: "2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming)" EXACT [EC:1.14.12.14]
synonym: "2-aminobenzenesulphonate 2,3-dioxygenase activity" EXACT []
synonym: "2-aminosulfobenzene 2,3-dioxygenase activity" EXACT [EC:1.14.12.14]
xref: EC:1.14.12.14
xref: MetaCyc:2ASDOSALCAL-RXN
xref: UM-BBD_enzymeID:e0192
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018628
name: terephthalate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: terephthalate + NADH + H+ + O2 = (1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+." [EC:1.14.12.15]
synonym: "1,4-dicarboxybenzoate 1,2-dioxygenase activity" EXACT [EC:1.14.12.15]
synonym: "benzene-1,4-dicarboxylate 1,2-dioxygenase activity" EXACT [EC:1.14.12.15]
synonym: "benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.15]
xref: EC:1.14.12.15
xref: MetaCyc:1.14.12.15-RXN
xref: UM-BBD_enzymeID:e0107
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018629
name: 2-hydroxyquinoline 5,6-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+." [EC:1.14.12.16]
synonym: "2-oxo-1,2-dihydroquinoline 5,6-dioxygenase activity" EXACT []
synonym: "quinolin-2(1H)-one 5,6-dioxygenase activity" EXACT [EC:1.14.12.16]
synonym: "quinolin-2-ol 5,6-dioxygenase activity" EXACT [EC:1.14.12.16]
synonym: "quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)" EXACT [EC:1.14.12.16]
xref: EC:1.14.12.16
xref: MetaCyc:1.14.12.16-RXN
xref: UM-BBD_enzymeID:e0046
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018630
name: 3,5-xylenol methylhydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol." [UM-BBD_enzymeID:e0287]
xref: EC:1.14.13.-
xref: MetaCyc:3-5-XYLENOL-METHYLHYDROXYLASE-RXN
xref: UM-BBD_enzymeID:e0287
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018631
name: phenylacetate hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate." [UM-BBD_enzymeID:e0197]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0197
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018632
name: 4-nitrophenol 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + NO2(-) (nitrite) + p-benzoquinone." [UM-BBD_enzymeID:e0201]
xref: EC:1.14.13.-
xref: MetaCyc:RXN-8739
xref: UM-BBD_enzymeID:e0201
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018633
name: dimethyl sulfide monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde." [UM-BBD_enzymeID:e0189]
synonym: "dimethyl sulphide monooxygenase activity" EXACT []
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0189
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018634
name: alpha-pinene monooxygenase [NADH] activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide." [UM-BBD_enzymeID:e0443]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0443
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018635
name: limonene 1,2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-(4R)-limonene + NADH + O2 = NAD+ + OH- + (4R)-limonene-1,2-epoxide." [UM-BBD_enzymeID:e0462]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0462
is_a: GO:0019113 ! limonene monooxygenase activity

[Term]
id: GO:0018636
name: phenanthrene 9,10-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide." [UM-BBD_enzymeID:e0334]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0334
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018637
name: 1-hydroxy-2-naphthoate hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NADPH + 2 H+ = NADP+ + H2O + CO2 + 1,2-dihydroxynaphthalene." [UM-BBD_enzymeID:e0332]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0332
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018638
name: toluene 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene + 1/2 O2 = 4-hydroxytoluene." [UM-BBD_enzymeID:e0225]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0225
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018639
name: xylene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene + 1/2 O2 = benzyl alcohol or xylene + 1/2 O2 = methylbenzyl alcohol." [UM-BBD_enzymeID:e0172]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0172
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018640
name: dibenzothiophene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O." [MetaCyc:RXN-621]
xref: EC:1.14.13.-
xref: MetaCyc:RXN-621
xref: UM-BBD_enzymeID:e0214
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018641
name: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [UM-BBD_enzymeID:e0043]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0043
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018642
name: chlorophenol 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol." [UM-BBD_enzymeID:e0252]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0252
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018643
name: carbon disulfide oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide." [UM-BBD_enzymeID:e0401]
synonym: "carbon disulphide oxygenase activity" EXACT []
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0401
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018644
name: toluene 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene." [UM-BBD_enzymeID:e0222]
xref: EC:1.14.13.-
xref: MetaCyc:TOLUENE-2-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0222
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018645
name: alkene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O." [EC:1.14.13.69]
synonym: "alkene epoxygenase activity" EXACT [EC:1.14.13.69]
synonym: "alkene,NADH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.69]
xref: EC:1.14.13.69
xref: MetaCyc:1.14.13.69-RXN
xref: UM-BBD_enzymeID:e0039
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018646
name: 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate." [UM-BBD_enzymeID:e0464]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0464
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018647
name: phenanthrene 1,2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide." [UM-BBD_enzymeID:e0333]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0333
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018648
name: methanesulfonate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methanesulfonate + FMNH2 + O2 = formaldehyde + FMN + sulfite + H2O." [EC:1.14.14.6]
synonym: "mesylate monooxygenase activity" EXACT [EC:1.14.14.6]
synonym: "mesylate,reduced-FMN:oxygen oxidoreductase activity" EXACT [EC:1.14.14.6]
synonym: "methanesulfonic acid monooxygenase activity" EXACT [EC:1.14.14.6]
synonym: "methanesulphonic acid monooxygenase activity" EXACT [GOC:mah]
synonym: "MSA monooxygenase activity" EXACT [EC:1.14.14.6]
synonym: "MSAMO activity" EXACT [EC:1.14.14.6]
synonym: "MsmABC" RELATED [EC:1.14.14.6]
xref: EC:1.14.14.6
xref: UM-BBD_enzymeID:e0264
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018649
name: tetrahydrofuran hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran." [UM-BBD_enzymeID:e0015]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0015
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018650
name: styrene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide." [UM-BBD_enzymeID:e0195]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0195
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018651
name: toluene-4-sulfonate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene." [UM-BBD_enzymeID:e0243]
synonym: "toluene-4-sulphonate monooxygenase activity" EXACT []
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0243
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018652
name: toluene-sulfonate methyl-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol." [UM-BBD_enzymeID:e0238]
synonym: "toluene-sulphonate methyl-monooxygenase activity" EXACT []
xref: EC:1.14.13.-
xref: MetaCyc:TSMOS-RXN
xref: UM-BBD_enzymeID:e0238
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018653
name: 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [EC:1.14.13.-]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0042
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018654
name: 2-hydroxy-phenylacetate hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate." [UM-BBD_enzymeID:e0198]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0198
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018655
name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA." [UM-BBD_enzymeID:e0304]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0304
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018656
name: phenanthrene 3,4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide." [UM-BBD_enzymeID:e0347]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0347
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018657
name: toluene 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: toluene + 1/2 O2 = 3-hydroxytoluene." [UM-BBD_enzymeID:e0224]
xref: EC:1.14.13.-
xref: MetaCyc:TOLUENE-3-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0224
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018658
name: salicylate 1-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2." [EC:1.14.13.1]
subset: gosubset_prok
synonym: "salicylate 1-hydroxylase activity" EXACT [EC:1.14.13.1]
synonym: "salicylate hydroxylase (decarboxylating)" EXACT [EC:1.14.13.1]
synonym: "salicylate hydroxylase activity" EXACT []
synonym: "salicylate monooxygenase activity" EXACT [EC:1.14.13.1]
synonym: "salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.1]
synonym: "salicylic hydroxylase activity" EXACT [EC:1.14.13.1]
xref: EC:1.14.13.1
xref: MetaCyc:SALICYLATE-1-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0149
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018659
name: 4-hydroxybenzoate 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O." [EC:1.14.13.2]
subset: gosubset_prok
synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.2]
synonym: "4-hydroxybenzoate monooxygenase activity" EXACT [EC:1.14.13.2]
synonym: "4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.2]
synonym: "p-hydroxybenzoate hydrolyase activity" EXACT [EC:1.14.13.2]
synonym: "p-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2]
synonym: "p-hydroxybenzoate-3-hydroxylase activity" EXACT [EC:1.14.13.2]
synonym: "p-hydroxybenzoic acid hydrolase activity" EXACT [EC:1.14.13.2]
synonym: "p-hydroxybenzoic acid hydroxylase activity" BROAD [EC:1.14.13.2]
synonym: "p-hydroxybenzoic hydroxylase activity" EXACT [EC:1.14.13.2]
synonym: "para-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2]
xref: EC:1.14.13.2
xref: MetaCyc:4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0084
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018660
name: 4-hydroxyphenylacetate 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O." [EC:1.14.13.3]
subset: gosubset_prok
synonym: "4 HPA 3-hydroxylase activity" EXACT [EC:1.14.13.3]
synonym: "4-hydroxyphenylacetate 3-hydroxylase activity" EXACT []
synonym: "4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.3]
synonym: "4-hydroxyphenylacetic acid-3-hydroxylase activity" EXACT [EC:1.14.13.3]
synonym: "p-hydroxyphenylacetate 3-hydroxylase activity" EXACT [EC:1.14.13.3]
synonym: "p-hydroxyphenylacetate hydroxylase activity" EXACT [EC:1.14.13.3]
xref: EC:1.14.13.3
xref: MetaCyc:1.14.13.3-RXN
xref: UM-BBD_enzymeID:e0150
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018661
name: orcinol 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: orcinol + NADH + H+ + O2 = 2,3,5-trihydroxytoluene + NAD+ + H2O." [EC:1.14.13.6]
synonym: "orcinol hydroxylase activity" EXACT []
synonym: "orcinol,NADH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.6]
xref: EC:1.14.13.6
xref: MetaCyc:ORCINOL-2-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0073
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018662
name: phenol 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O." [EC:1.14.13.7]
subset: gosubset_prok
synonym: "phenol hydroxylase activity" EXACT [EC:1.14.13.7]
synonym: "phenol o-hydroxylase activity" EXACT [EC:1.14.13.7]
synonym: "phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.7]
xref: EC:1.14.13.7
xref: MetaCyc:PHENOL-2-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0208
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018663
name: 2,6-dihydroxypyridine 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dihydroxypyridine + NADH + H+ + O2 = 2,3,6-trihydroxypyridine + NAD+ + H2O." [EC:1.14.13.10]
synonym: "2,6-dihydroxypyridine oxidase activity" EXACT []
synonym: "2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.10]
xref: EC:1.14.13.10
xref: MetaCyc:1.14.13.10-RXN
xref: UM-BBD_enzymeID:e0340
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018664
name: benzoate 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoate + NADPH + H+ + O2 = 4-hydroxybenzoate + NADP+ + H2O." [EC:1.14.13.12]
synonym: "4-hydroxybenzoic hydroxylase activity" EXACT []
synonym: "benzoate 4-hydroxylase activity" EXACT [EC:1.14.13.12]
synonym: "benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.12]
synonym: "benzoate-p-hydroxylase activity" EXACT [EC:1.14.13.12]
synonym: "benzoate-para-hydroxylase activity" EXACT [EC:1.14.13.12]
synonym: "benzoic 4-hydroxylase activity" EXACT [EC:1.14.13.12]
synonym: "benzoic acid 4-hydroxylase activity" EXACT [EC:1.14.13.12]
synonym: "p-hydroxybenzoate hydroxylase activity" EXACT [EC:1.14.13.12]
xref: EC:1.14.13.12
xref: MetaCyc:BENZOATE-4-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0414
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018665
name: 4-hydroxyphenylacetate 1-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O." [EC:1.14.13.18]
synonym: "4-HPA 1-hydroxylase activity" EXACT [EC:1.14.13.18]
synonym: "4-hydroxyphenyl-acetate 1-hydroxylase activity" EXACT []
synonym: "4-hydroxyphenylacetate 1-hydroxylase activity" EXACT [EC:1.14.13.18]
synonym: "4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)" EXACT [EC:1.14.13.18]
synonym: "4-hydroxyphenylacetic 1-hydroxylase activity" EXACT [EC:1.14.13.18]
xref: EC:1.14.13.18
xref: MetaCyc:1.14.13.18-RXN
xref: UM-BBD_enzymeID:e0151
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018666
name: 2,4-dichlorophenol 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O." [EC:1.14.13.20]
subset: gosubset_prok
synonym: "2,4-dichlorophenol hydroxylase activity" EXACT []
synonym: "2,4-dichlorophenol monooxygenase activity" EXACT [EC:1.14.13.20]
synonym: "2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.20]
xref: EC:1.14.13.20
xref: MetaCyc:24-DICHLOROPHENOL-6-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0152
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018667
name: cyclohexanone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O." [EC:1.14.13.22]
subset: gosubset_prok
synonym: "cyclohexanone 1,2-monooxygenase activity" EXACT []
synonym: "cyclohexanone oxygenase activity" EXACT [EC:1.14.13.22]
synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing) activity" EXACT [EC:1.14.13.22]
synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming)" EXACT [EC:1.14.13.22]
xref: EC:1.14.13.22
xref: MetaCyc:CYCLOHEXANONE-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0166
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018668
name: 3-hydroxybenzoate 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxybenzoate + NADPH + H+ + O2 = 3,4-dihydroxybenzoate + NADP+ + H2O." [EC:1.14.13.23]
synonym: "3-hydroxybenzoate 4-hydroxylase activity" EXACT []
synonym: "3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.23]
xref: EC:1.14.13.23
xref: MetaCyc:3-HYDROXYBENZOATE-4-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0109
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018669
name: 3-hydroxybenzoate 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxybenzoate + NADH + H+ + O2 = 2,5-dihydroxybenzoate + NAD+ + H2O." [EC:1.14.13.24]
synonym: "3-hydroxybenzoate 6-hydroxylase activity" EXACT []
synonym: "3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.24]
synonym: "3-hydroxybenzoic acid-6-hydroxylase activity" EXACT [EC:1.14.13.24]
synonym: "m-hydroxybenzoate 6-hydroxylase activity" EXACT [EC:1.14.13.24]
xref: EC:1.14.13.24
xref: MetaCyc:3-HYDROXYBENZOATE-6-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0289
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018670
name: 4-aminobenzoate 1-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2." [EC:1.14.13.27]
synonym: "4-aminobenzoate dehydrogenase activity" EXACT [EC:1.14.13.27]
synonym: "4-aminobenzoate hydroxylase activity" EXACT []
synonym: "4-aminobenzoate monooxygenase activity" EXACT [EC:1.14.13.27]
synonym: "4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.27]
xref: EC:1.14.13.27
xref: MetaCyc:4-AMINOBENZOATE-1-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0400
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018671
name: 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O." [EC:1.14.13.33]
synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.33]
synonym: "4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide (phosphate))" EXACT []
synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.33]
synonym: "4-hydroxybenzoate-3-hydroxylase activity" EXACT [EC:1.14.13.33]
xref: EC:1.14.13.33
xref: MetaCyc:1.14.13.33-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018672
name: anthranilate 3-monooxygenase (deaminating) activity
namespace: molecular_function
def: "Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = 2,3-dihydroxybenzoate + NADP+ + NH3." [EC:1.14.13.35]
synonym: "anthranilate 2,3-dioxygenase (deaminating)" EXACT [EC:1.14.13.35]
synonym: "anthranilate 2,3-hydroxylase (deaminating) activity" EXACT [EC:1.14.13.35]
synonym: "anthranilate hydroxylase (deaminating) activity" EXACT []
synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.13.35]
synonym: "anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating)" EXACT [EC:1.14.13.35]
xref: EC:1.14.13.35
xref: MetaCyc:1.14.13.35-RXN
xref: UM-BBD_enzymeID:e0382
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018673
name: anthraniloyl-CoA monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+." [EC:1.14.13.40]
subset: gosubset_prok
synonym: "2-aminobenzoyl-CoA monooxygenase/reductase activity" EXACT [EC:1.14.13.40]
synonym: "2-aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)" EXACT [EC:1.14.13.40]
synonym: "anthraniloyl coenzyme A reductase activity" EXACT [EC:1.14.13.40]
xref: EC:1.14.13.40
xref: MetaCyc:ANTHRANILOYL-COA-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0370
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018674
name: (S)-limonene 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-isopiperitenol + NADP+ + H2O." [EC:1.14.13.47]
synonym: "(-)-limonene 3-hydroxylase activity" EXACT [EC:1.14.13.47]
synonym: "(-)-limonene 3-monooxygenase activity" EXACT []
synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.13.47]
synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.47]
synonym: "limonene 3-hydroxylase activity" EXACT []
xref: EC:1.14.13.47
xref: MetaCyc:--LIMONENE-3-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0467
is_a: GO:0019113 ! limonene monooxygenase activity

[Term]
id: GO:0018675
name: (S)-limonene 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O." [EC:1.14.13.48]
synonym: "(-)-limonene 6-hydroxylase activity" EXACT [EC:1.14.13.48]
synonym: "(-)-limonene 6-monooxygenase activity" EXACT []
synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" EXACT [EC:1.14.13.48]
synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.48]
synonym: "limonene 6-hydroxylase activity" EXACT []
xref: EC:1.14.13.48
xref: MetaCyc:--LIMONENE-6-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0445
is_a: GO:0019113 ! limonene monooxygenase activity

[Term]
id: GO:0018676
name: (S)-limonene 7-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-perillyl alcohol + NADP+ + H2O." [EC:1.14.13.49]
synonym: "(-)-limonene 7-monooxygenase activity" EXACT []
synonym: "(-)-limonene hydroxylase activity" EXACT [EC:1.14.13.49]
synonym: "(-)-limonene monooxygenase activity" EXACT [EC:1.14.13.49]
synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (7-hydroxylating) activity" EXACT [EC:1.14.13.49]
synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.14.13.49]
synonym: "limonene hydroxylase activity" EXACT []
xref: EC:1.14.13.49
xref: MetaCyc:--LIMONENE-7-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0458
is_a: GO:0019113 ! limonene monooxygenase activity

[Term]
id: GO:0018677
name: pentachlorophenol monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride." [EC:1.14.13.50]
subset: gosubset_prok
synonym: "PCB 4-monooxygenase activity" EXACT [EC:1.14.13.50]
synonym: "PCB4MO activity" EXACT [EC:1.14.13.50]
synonym: "PCP hydroxylase activity" EXACT [EC:1.14.13.50]
synonym: "PcpB" RELATED [EC:1.14.13.50]
synonym: "pentachlorophenol 4-monooxygenase activity" EXACT []
synonym: "pentachlorophenol dechlorinase activity" EXACT [EC:1.14.13.50]
synonym: "pentachlorophenol dehalogenase activity" EXACT [EC:1.14.13.50]
synonym: "pentachlorophenol hydroxylase activity" EXACT []
synonym: "pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)" EXACT [EC:1.14.13.50]
xref: EC:1.14.13.50
xref: MetaCyc:PENTACHLOROPHENOL-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0148
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018678
name: 4-hydroxybenzoate 1-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2." [EC:1.14.13.64]
synonym: "4-hydroxybenzoate 1-monooxygenase activity" EXACT []
synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.64]
xref: EC:1.14.13.64
xref: MetaCyc:1.14.13.64-RXN
xref: UM-BBD_enzymeID:e0476
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018679
name: dibenzothiophene-5,5-dioxide monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate." [UM-BBD_enzymeID:e0215]
xref: EC:1.14.14.-
xref: MetaCyc:RXN-623
xref: UM-BBD_enzymeID:e0215
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018680
name: deethylatrazine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine." [UM-BBD_enzymeID:e0098]
xref: EC:1.14.15.-
xref: UM-BBD_enzymeID:e0098
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018681
name: deisopropylatrazine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 CH3CHO + 2 deisopropyldeethylatrazine." [UM-BBD_enzymeID:e0094]
xref: EC:1.14.15.-
xref: UM-BBD_enzymeID:e0094
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018682
name: atrazine N-dealkylase activity
namespace: molecular_function
def: "Catalysis of the reaction: atrazine + O2 + 2 H+ = deethylatrazine + acetaldehyde + H2O." [MetaCyc:R461-RXN, UM-BBD_reactionID:r0127]
synonym: "atrazine monooxygenase activity" RELATED [UM-BBD_enzymeID:e0090]
xref: EC:1.14.15.-
xref: MetaCyc:R461-RXN
xref: UM-BBD_reactionID:r0127
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018683
name: camphor 5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O." [EC:1.14.15.1]
subset: gosubset_prok
synonym: "(+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.15.1]
synonym: "2-bornanone 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "bornanone 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "camphor 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "camphor 5-exo-methylene hydroxylase activity" EXACT []
synonym: "camphor 5-exohydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "camphor hydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "camphor methylene hydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "cytochrome p450-cam activity" EXACT [EC:1.14.15.1]
synonym: "d-camphor monooxygenase activity" EXACT [EC:1.14.15.1]
synonym: "D-camphor-exo-hydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "methylene hydroxylase activity" EXACT [EC:1.14.15.1]
synonym: "methylene monooxygenase activity" EXACT [EC:1.14.15.1]
xref: EC:1.14.15.1
xref: MetaCyc:R541-RXN
xref: UM-BBD_enzymeID:e0300
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018684
name: camphor 1,2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-bornane-2,5-dione + reduced rubredoxin + O2 = 5-oxo-1,2-campholide + oxidized rubredoxin + H2O." [EC:1.14.15.2]
synonym: "(+)-camphor,reduced-rubredoxin:oxygen oxidoreductase (1,2-lactonizing)" EXACT [EC:1.14.15.2]
synonym: "2,5-diketocamphane lactonizing enzyme activity" EXACT [EC:1.14.15.2]
synonym: "camphor ketolactonase I activity" EXACT [EC:1.14.15.2]
synonym: "ketolactonase I" RELATED [EC:1.14.15.2]
synonym: "oxygenase, camphor 1,2-mono" EXACT [EC:1.14.15.2]
xref: EC:1.14.15.2
xref: MetaCyc:CAMPHOR-12-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0302
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018685
name: alkane 1-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3]
subset: gosubset_prok
synonym: "1-hydroxylase activity" EXACT [EC:1.14.15.3]
synonym: "alkane 1-hydroxylase activity" EXACT []
synonym: "alkane hydroxylase activity" EXACT [EC:1.14.15.3]
synonym: "alkane monooxygenase activity" EXACT [EC:1.14.15.3]
synonym: "alkane,reduced-rubredoxin:oxygen 1-oxidoreductase activity" EXACT [EC:1.14.15.3]
synonym: "fatty acid omega-hydroxylase activity" NARROW [EC:1.14.15.3]
synonym: "lauric acid omega-hydroxylase activity" NARROW [EC:1.14.15.3]
synonym: "omega-hydroxylase activity" RELATED [EC:1.14.15.3]
xref: EC:1.14.15.3
xref: MetaCyc:ALKANE-1-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0022
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018686
name: 6-hydroxy pseudo-oxynicotine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine." [UM-BBD_enzymeID:e0342]
xref: EC:1.14.18.-
xref: UM-BBD_enzymeID:e0342
is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0018687
name: biphenyl 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD; requires Fe2+." [EC:1.14.12.18]
subset: gosubset_prok
synonym: "biphenyl dioxygenase activity" EXACT [EC:1.14.12.18]
synonym: "biphenyl,NADH:oxygen oxidoreductase (2,3-hydroxylating)" EXACT [EC:1.14.12.18]
xref: EC:1.14.12.18
xref: MetaCyc:1.14.12.18-RXN
xref: UM-BBD_enzymeID:e0089
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0018688
name: DDT 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT." [UM-BBD_enzymeID:e0319]
xref: EC:1.14.99.-
xref: UM-BBD_enzymeID:e0319
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0018689
name: naphthalene disulfonate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene)." [UM-BBD_enzymeID:e0249]
synonym: "naphthalene disulphonate 1,2-dioxygenase activity" EXACT []
xref: EC:1.14.99.-
xref: UM-BBD_enzymeID:e0249
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018690
name: 4-methoxybenzoate monooxygenase (O-demethylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methoxybenzoate + donor-H2 + O2 = 4-hydroxybenzoate + formaldehyde + acceptor + H2O." [EC:1.14.99.15]
synonym: "4-methoxybenzoate 4-monooxygenase (O-demethylating)" EXACT [EC:1.14.99.15]
synonym: "4-methoxybenzoate monooxygenase activity" EXACT []
synonym: "4-methoxybenzoate O-demethylase activity" EXACT [EC:1.14.99.15]
synonym: "4-methoxybenzoate,hydrogen-donor:oxygen oxidoreductase (O-demethylating)" EXACT [EC:1.14.99.15]
synonym: "p-anisic O-demethylase activity" EXACT [EC:1.14.99.15]
synonym: "piperonylate-4-O-demethylase activity" EXACT [EC:1.14.99.15]
xref: EC:1.14.99.15
xref: MetaCyc:1.14.99.15-RXN
xref: UM-BBD_enzymeID:e0103
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0018691
name: arsenite oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: arsenite + 10 H2O = 20 H+ + 8 e- + arsenate." [UM-BBD_enzymeID:e0037]
xref: EC:1.16.-.-
xref: MetaCyc:1.20.98.1-RXN
xref: MetaCyc:RXN-7837
xref: UM-BBD_enzymeID:e0037
is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions

[Term]
id: GO:0018693
name: ethylbenzene hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethylbenzene + H2O + acceptor = (S)-1-phenylethanol + reduced acceptor." [EC:1.17.99.2]
synonym: "ethylbenzene dehydrogenase activity" EXACT [EC:1.17.99.2]
synonym: "ethylbenzene:(acceptor) oxidoreductase activity" EXACT [EC:1.17.99.2]
xref: EC:1.17.99.2
xref: MetaCyc:RXN-1301
xref: UM-BBD_enzymeID:e0209
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0018694
name: p-cymene methyl hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol." [UM-BBD_enzymeID:e0199]
xref: EC:1.17.99.-
xref: MetaCyc:RXN-661
xref: UM-BBD_enzymeID:e0199
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0018695
name: 4-cresol dehydrogenase (hydroxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor." [EC:1.17.99.1]
subset: gosubset_prok
synonym: "4-cresol dehydrogenase activity" EXACT []
synonym: "4-cresol:acceptor oxidoreductase (methyl-hydroxylating)" EXACT [EC:1.17.99.1]
synonym: "p-cresol methylhydroxylase activity" EXACT [EC:1.17.99.1]
synonym: "p-cresol-(acceptor) oxidoreductase (hydroxylating) activity" EXACT [EC:1.17.99.1]
xref: EC:1.17.99.1
xref: MetaCyc:1.17.99.1-RXN
xref: UM-BBD_enzymeID:e0147
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0018697
name: carbonyl sulfide nitrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = H2S + carbon monoxide." [UM-BBD_enzymeID:e0402]
synonym: "carbonyl sulphide nitrogenase activity" EXACT []
xref: EC:1.18.6.-
xref: UM-BBD_enzymeID:e0402
is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor

[Term]
id: GO:0018698
name: vinyl chloride reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: vinyl chloride + 2 H+ + 2 e- = HCl + ethene (ethylene)." [UM-BBD_enzymeID:e0273]
xref: EC:1.97.1.-
xref: MetaCyc:VCREDCHLOR-RXN
xref: UM-BBD_enzymeID:e0273
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018699
name: 1,1,1-trichloroethane reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,1,1-trichloroethane + 2 H+ + 2 e- = 1,1-dichloroethane + HCl." [UM-BBD_reactionID:r1007]
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0626
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018700
name: 2-chloro-N-isopropylacetanilide reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide." [UM-BBD_enzymeID:e0450]
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0450
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018701
name: 2,5-dichlorohydroquinone reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone)." [UM-BBD_enzymeID:e0366]
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0366
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018702
name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_enzymeID:e0312]
synonym: "1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene dehalogenase activity" EXACT []
synonym: "DDE dehalogenase activity" EXACT []
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0312
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018703
name: 2,4-dichlorophenoxyacetate dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate." [UM-BBD_enzymeID:e0233]
xref: UM-BBD_enzymeID:e0233
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018704
name: 5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-chloro-2-hydroxymuconic semialdehyde + H+ + 2 e- = Cl- + 2-hydroxymuconic semialdehyde." [UM-BBD_enzymeID:e0237]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0237
is_obsolete: true

[Term]
id: GO:0018705
name: 1,2-dichloroethene reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride." [UM-BBD_enzymeID:e0272]
synonym: "1,2-dichloroethylene reductive dehalogenase activity" EXACT []
xref: UM-BBD_enzymeID:e0272
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018706
name: pyrogallol hydroxytransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene." [EC:1.97.1.2]
subset: gosubset_prok
synonym: "1,2,3,5-tetrahydroxybenzene hydroxyltransferase activity" EXACT [EC:1.97.1.2]
synonym: "1,2,3,5-tetrahydroxybenzene-pyrogallol hydroxyltransferase (transhydroxylase)" EXACT [EC:1.97.1.2]
synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxyltransferase activity" EXACT [EC:1.97.1.2]
synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase activity" EXACT [EC:1.97.1.2]
synonym: "1,2,3,5-tetrahydroxybenzene:pyrogallol transhydroxylase activity" EXACT [EC:1.97.1.2]
synonym: "pyrogallol hydroxyltransferase activity" EXACT []
synonym: "transhydroxylase activity" RELATED [EC:1.97.1.2]
xref: EC:1.97.1.2
xref: MetaCyc:1.97.1.2-RXN
xref: UM-BBD_enzymeID:e0009
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0018707
name: 1-phenanthrol methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene." [UM-BBD_enzymeID:e0336]
xref: EC:2.1.1.-
xref: UM-BBD_enzymeID:e0336
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0018708
name: thiol S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether." [EC:2.1.1.9]
synonym: "S-adenosyl-L-methionine:thiol S-methyltransferase activity" EXACT [EC:2.1.1.9]
synonym: "thiol methyltransferase activity" EXACT [EC:2.1.1.9]
synonym: "TMT" RELATED [EC:2.1.1.9]
xref: EC:2.1.1.9
xref: MetaCyc:THIOL-S-METHYLTRANSFERASE-RXN
xref: Reactome:9948 "thiol S-methyltransferase activity"
xref: UM-BBD_enzymeID:e0146
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0018710
name: acetone carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetone + ATP + 2 H2O + CO2 = AMP + 2 phosphate + acetoacetate." [EC:6.4.1.6]
synonym: "acetone:carbon-dioxide ligase (AMP-forming)" EXACT [EC:6.4.1.6]
xref: EC:6.4.1.6
xref: MetaCyc:6.4.1.6-RXN
is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds

[Term]
id: GO:0018711
name: benzoyl acetate-CoA thiolase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA." [UM-BBD_enzymeID:e0213]
xref: EC:2.3.1.-
xref: MetaCyc:RXN-1305
xref: UM-BBD_enzymeID:e0213
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0018712
name: 3-hydroxybutyryl-CoA thiolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA." [UM-BBD_enzymeID:e0013]
xref: EC:2.3.1.-
xref: MetaCyc:R7-RXN
xref: UM-BBD_enzymeID:e0013
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0018713
name: 3-ketopimelyl-CoA thiolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA." [UM-BBD_enzymeID:e0182]
xref: EC:2.3.1.-
xref: MetaCyc:RXN-8032
xref: UM-BBD_enzymeID:e0182
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0018715
name: 9-phenanthrol UDP-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP." [UM-BBD_enzymeID:e0377]
xref: EC:2.4.1.-
xref: UM-BBD_enzymeID:e0377
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0018716
name: 1-phenanthrol glycosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_enzymeID:e0356]
xref: EC:2.4.1.-
xref: UM-BBD_enzymeID:e0356
is_a: GO:0019112 ! phenanthrol glycosyltransferase activity

[Term]
id: GO:0018717
name: 9-phenanthrol glycosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_enzymeID:e0350]
xref: EC:2.4.1.-
xref: UM-BBD_enzymeID:e0350
is_a: GO:0019112 ! phenanthrol glycosyltransferase activity

[Term]
id: GO:0018718
name: 1,2-dihydroxy-phenanthrene glycosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP." [UM-BBD_enzymeID:e0378]
xref: EC:2.4.1.-
xref: UM-BBD_enzymeID:e0378
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0018719
name: 6-aminohexanoate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate." [UM-BBD_enzymeID:e0318]
xref: EC:2.6.1.-
xref: MetaCyc:R562-RXN
xref: UM-BBD_enzymeID:e0318
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0018720
name: phenol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate." [UM-BBD_enzymeID:e0157]
xref: EC:2.7.1.-
xref: MetaCyc:PHENOLPHOS-RXN
xref: UM-BBD_enzymeID:e0157
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0018721
name: trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate." [UM-BBD_enzymeID:e0369]
synonym: "trans-9R,10R-dihydrodiolphenanthrene sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
xref: UM-BBD_enzymeID:e0369
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0018722
name: 1-phenanthrol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate." [UM-BBD_enzymeID:e0373]
synonym: "1-phenanthrol sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
xref: UM-BBD_enzymeID:e0373
is_a: GO:0019111 ! phenanthrol sulfotransferase activity

[Term]
id: GO:0018723
name: 3-phenanthrol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate." [UM-BBD_enzymeID:e0374]
synonym: "3-phenanthrol sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
xref: UM-BBD_enzymeID:e0374
is_a: GO:0019111 ! phenanthrol sulfotransferase activity

[Term]
id: GO:0018724
name: 4-phenanthrol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate." [UM-BBD_enzymeID:e0375]
synonym: "4-phenanthrol sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
xref: UM-BBD_enzymeID:e0375
is_a: GO:0019111 ! phenanthrol sulfotransferase activity

[Term]
id: GO:0018725
name: trans-3,4-dihydrodiolphenanthrene sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate." [UM-BBD_enzymeID:e0368]
synonym: "trans-3,4-dihydrodiolphenanthrene sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
xref: UM-BBD_enzymeID:e0368
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0018726
name: 9-phenanthrol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate." [UM-BBD_enzymeID:e0376]
synonym: "9-phenanthrol sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
xref: UM-BBD_enzymeID:e0376
is_a: GO:0019111 ! phenanthrol sulfotransferase activity

[Term]
id: GO:0018727
name: 2-phenanthrol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate." [UM-BBD_enzymeID:e0372]
synonym: "2-phenanthrol sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
xref: UM-BBD_enzymeID:e0372
is_a: GO:0019111 ! phenanthrol sulfotransferase activity

[Term]
id: GO:0018729
name: propionate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA." [EC:2.8.3.1]
subset: gosubset_prok
synonym: "acetyl-CoA:propanoate CoA-transferase activity" EXACT [EC:2.8.3.1]
synonym: "propionate coenzyme A-transferase activity" EXACT [EC:2.8.3.1]
synonym: "propionate-CoA:lactoyl-CoA transferase activity" EXACT [EC:2.8.3.1]
synonym: "propionyl CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.1]
synonym: "propionyl-CoA transferase activity" EXACT [EC:2.8.3.1]
xref: EC:2.8.3.1
xref: MetaCyc:PROPIONATE-COA-TRANSFERASE-RXN
xref: UM-BBD_enzymeID:e0071
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0018730
name: glutaconate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA." [EC:2.8.3.12]
subset: gosubset_prok
synonym: "acetyl-CoA:(E)-glutaconate CoA-transferase activity" EXACT [EC:2.8.3.12]
xref: EC:2.8.3.12
xref: MetaCyc:GLUTACONATE-COA-TRANSFERASE-RXN
xref: UM-BBD_enzymeID:e0069
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0018731
name: 1-oxa-2-oxocycloheptane lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate." [UM-BBD_enzymeID:e0167]
xref: EC:3.1.1.-
xref: UM-BBD_enzymeID:e0167
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0018732
name: sulfolactone hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate." [UM-BBD_enzymeID:e0384]
synonym: "sulpholactone hydrolase activity" EXACT []
xref: EC:3.1.1.-
xref: UM-BBD_enzymeID:e0384
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0018733
name: 3,4-dihydrocoumarin hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate." [UM-BBD_enzymeID:e0297]
xref: EC:3.1.1.-
xref: UM-BBD_enzymeID:e0297
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0018734
name: butyrolactone hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate." [UM-BBD_enzymeID:e0017]
xref: EC:3.1.1.-
xref: UM-BBD_enzymeID:e0017
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0018736
name: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA." [UM-BBD_enzymeID:e0187]
xref: EC:3.7.1.-
xref: UM-BBD_enzymeID:e0187
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018737
name: 2-ketocyclohexane-1-carboxyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA." [UM-BBD_enzymeID:e0178]
xref: EC:3.7.1.-
xref: UM-BBD_enzymeID:e0178
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018738
name: S-formylglutathione hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-formylglutathione + H2O = glutathione + formate." [EC:3.1.2.12]
subset: gosubset_prok
xref: EC:3.1.2.12
xref: MetaCyc:S-FORMYLGLUTATHIONE-HYDROLASE-RXN
xref: UM-BBD_enzymeID:e0141
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0018739
name: 4-hydroxybenzoyl-CoA thioesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA." [EC:3.1.2.23]
subset: gosubset_prok
synonym: "4-hydroxybenzoyl-CoA hydrolase activity" EXACT [EC:3.1.2.23]
synonym: "4-hydroxybenzoyl-CoA thiolesterase activity" EXACT []
xref: EC:3.1.2.23
xref: MetaCyc:3.1.2.23-RXN
xref: UM-BBD_enzymeID:e0118
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0018740
name: 2'-hydroxybiphenyl-2-sulfinate desulfinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(2-hydroxyphenyl)benzenesulfinate + H2O = 2-hydroxybiphenyl + SO3(2-) (sulfite)." [EC:3.13.1.3]
subset: gosubset_prok
synonym: "2'-hydroxybiphenyl-2-sulfinate sulfinolyase activity" EXACT []
synonym: "2'-hydroxybiphenyl-2-sulfinate sulfohydrolase activity" EXACT [EC:3.13.1.3]
synonym: "2-(2'-hydroxyphenyl)benzenesulfinate desulfinase activity" EXACT [EC:3.13.1.3]
synonym: "2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase activity" EXACT [EC:3.13.1.3]
synonym: "2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase activity" EXACT [EC:3.13.1.3]
synonym: "2-(2-hydroxyphenyl)benzenesulfinate desulfinase activity" EXACT [EC:3.13.1.3]
synonym: "2-(2-hydroxyphenyl)benzenesulfinate hydrolase activity" EXACT [EC:3.13.1.3]
synonym: "2-(2-hydroxyphenyl)benzenesulphinate hydrolase activity" EXACT []
synonym: "dibenzothiophene desulfurization enzyme B" RELATED [EC:3.13.1.3]
synonym: "DszB" RELATED [EC:3.13.1.3]
synonym: "gene dszB-encoded hydrolase activity" EXACT [EC:3.13.1.3]
synonym: "HBPSi desulfinase activity" EXACT [EC:3.13.1.3]
synonym: "HPBS desulfinase activity" EXACT [EC:3.13.1.3]
xref: EC:3.13.1.3
xref: MetaCyc:RXN-624
xref: UM-BBD_enzymeID:e0216
is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds

[Term]
id: GO:0018741
name: alkyl sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dodecyl sulfate + H2O = SO4(2-) (sulfate) + H+ + 1-dodecanol." [UM-BBD_enzymeID:e0403]
synonym: "alkyl sulphatase activity" EXACT []
xref: EC:3.1.6.-
xref: UM-BBD_enzymeID:e0403
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0018742
name: epoxide hydrolase B activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers." [UM-BBD_enzymeID:e0051]
xref: EC:3.3.2.-
xref: UM-BBD_enzymeID:e0051
is_a: GO:0004301 ! epoxide hydrolase activity

[Term]
id: GO:0018743
name: phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene." [UM-BBD_enzymeID:e0367]
xref: EC:3.3.2.-
xref: UM-BBD_enzymeID:e0367
is_a: GO:0019119 ! phenanthrene-9,10-epoxide hydrolase activity

[Term]
id: GO:0018744
name: limonene-1,2-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide." [EC:3.3.2.8]
subset: gosubset_prok
synonym: "limonene oxide hydrolase activity" EXACT [EC:3.3.2.8]
xref: EC:3.3.2.8
xref: MetaCyc:3.3.2.8-RXN
xref: UM-BBD_enzymeID:e0470
is_a: GO:0004301 ! epoxide hydrolase activity

[Term]
id: GO:0018745
name: epoxide hydrolase A activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol." [UM-BBD_enzymeID:e0049]
xref: EC:3.3.2.-
xref: UM-BBD_enzymeID:e0049
is_a: GO:0004301 ! epoxide hydrolase activity

[Term]
id: GO:0018746
name: phenanthrene-3,4-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene." [UM-BBD_enzymeID:e0363]
xref: EC:3.3.2.-
xref: UM-BBD_enzymeID:e0363
is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity

[Term]
id: GO:0018747
name: phenanthrene-1,2-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene." [UM-BBD_enzymeID:e0364]
xref: EC:3.3.2.-
xref: UM-BBD_enzymeID:e0364
is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity

[Term]
id: GO:0018748
name: iprodione amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate." [UM-BBD_enzymeID:e0438]
xref: EC:3.5.1.-
xref: UM-BBD_enzymeID:e0438
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0018749
name: (3,5-dichlorophenylurea)acetate amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine." [UM-BBD_enzymeID:e0440]
xref: EC:3.5.1.-
xref: UM-BBD_enzymeID:e0440
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0018750
name: biuret amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3." [EC:3.5.1.84]
xref: EC:3.5.1.84
xref: UM-BBD_enzymeID:e0088
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0018751
name: 3,5-dichlorophenylcarboximide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate." [UM-BBD_enzymeID:e0439]
xref: EC:3.5.2.-
xref: UM-BBD_enzymeID:e0439
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0018752
name: epsilon-caprolactam lactamase activity
namespace: molecular_function
def: "Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate." [UM-BBD_enzymeID:e0317]
xref: EC:3.5.2.-
xref: MetaCyc:R561-RXN
xref: UM-BBD_enzymeID:e0317
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0018753
name: cyanuric acid amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanuric acid + H2O = biuret + CO2." [EC:3.5.2.15]
subset: gosubset_prok
xref: EC:3.5.2.15
xref: MetaCyc:R468-RXN
xref: UM-BBD_enzymeID:e0087
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0018754
name: ammelide aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3." [PMID:1991731]
xref: EC:3.5.3.-
xref: MetaCyc:RXN-8017
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0018755
name: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity
namespace: molecular_function
def: "2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-." [UM-BBD_reactionID:r1414]
xref: EC:3.5.3.-
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0018756
name: ammeline aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ammeline + H2O = ammelide + NH3." [PMID:1991731]
xref: EC:3.5.3.-
xref: MetaCyc:RXN-8016
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0018757
name: deisopropylhydroxyatrazine aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine." [UM-BBD_enzymeID:e0092]
xref: EC:3.5.3.-
xref: UM-BBD_enzymeID:e0092
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0018758
name: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid." [UM-BBD_enzymeID:e0093]
xref: EC:3.5.3.-
xref: UM-BBD_enzymeID:e0093
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0018759
name: methenyltetrahydromethanopterin cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = N5-formyl-5,6,7,8-tetrahydromethanopterin." [EC:3.5.4.27]
subset: gosubset_prok
synonym: "5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing)" EXACT [EC:3.5.4.27]
synonym: "5,10-methenyltetrahydromethanopterin cyclohydrolase activity" EXACT [EC:3.5.4.27]
synonym: "methenyl-H(4)MPT cyclohydrolase activity" EXACT [EC:3.5.4.27]
synonym: "methenyl-H4MPT cyclohydrolase activity" EXACT [EC:3.5.4.27]
synonym: "N5,N10-methenyltetrahydromethanopterin cyclohydrolase activity" EXACT [EC:3.5.4.27]
xref: EC:3.5.4.27
xref: MetaCyc:3.5.4.27-RXN
xref: UM-BBD_enzymeID:e0140
is_a: GO:0019238 ! cyclohydrolase activity

[Term]
id: GO:0018760
name: thiocyanate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiocyanate + H2O = NH3 + carbonyl sulfide." [UM-BBD_enzymeID:e0399]
synonym: "thiocyanate aminohydrolase activity" EXACT [EC:3.5.5.8]
xref: EC:3.5.5.8
xref: MetaCyc:RXN-1761
xref: UM-BBD_enzymeID:e0399
is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles

[Term]
id: GO:0018761
name: bromoxynil nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxy-benzoate + NH3. Involved in the bacterial degradation of the herbicide bromoxynil." [EC:3.5.5.6]
subset: gosubset_prok
synonym: "3,5-dibromo-4-hydroxybenzonitrile aminohydrolase activity" EXACT []
synonym: "bromoxynil-specific nitrilase activity" EXACT []
xref: EC:3.5.5.6
xref: MetaCyc:3.5.5.6-RXN
xref: UM-BBD_enzymeID:e0357
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0018762
name: aliphatic nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: R-CN + H2O = R-COOH + NH3." [EC:3.5.5.7]
subset: gosubset_prok
synonym: "aliphatic nitrile aminohydrolase activity" EXACT [EC:3.5.5.7]
xref: EC:3.5.5.7
xref: MetaCyc:3.5.5.7-RXN
xref: UM-BBD_enzymeID:e0413
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0018763
name: hydroxydechloroatrazine ethylaminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine." [EC:3.5.99.3]
subset: gosubset_prok
synonym: "4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase activity" EXACT [EC:3.5.99.3]
synonym: "AtzB" RELATED [EC:3.5.99.3]
synonym: "hydroxyatrazine ethylaminohydrolase activity" EXACT []
synonym: "hydroxyatrazine hydrolase activity" EXACT [EC:3.5.99.3]
xref: EC:3.5.99.3
xref: MetaCyc:R122-RXN
xref: UM-BBD_enzymeID:e0085
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0018764
name: N-isopropylammelide isopropylaminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine." [EC:3.5.99.4]
subset: gosubset_prok
synonym: "AtzC" RELATED [EC:3.5.99.4]
xref: EC:3.5.99.4
xref: MetaCyc:R123-RXN
xref: UM-BBD_enzymeID:e0086
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0018765
name: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate." [UM-BBD_enzymeID:e0223]
xref: EC:3.7.1.-
xref: MetaCyc:2-OH-6-OXOHEPTA-2-4-DIENOATE-HYDR-RXN
xref: UM-BBD_enzymeID:e0223
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018766
name: dihydrophloroglucinol hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate." [UM-BBD_enzymeID:e0011]
xref: EC:3.7.1.-
xref: MetaCyc:R6-RXN
xref: UM-BBD_enzymeID:e0011
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018767
name: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate." [UM-BBD_enzymeID:e0102]
xref: EC:3.7.1.-
xref: UM-BBD_enzymeID:e0102
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018768
name: 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoat + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_enzymeID:e0325]
xref: EC:3.7.1.-
xref: UM-BBD_enzymeID:e0325
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018769
name: 2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_enzymeID:e0221]
xref: EC:3.7.1.-
xref: UM-BBD_enzymeID:e0221
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018770
name: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2Z,4Z,7-trienoate + H2O = 2-(4'-chlorophenyl)-3,3-dichloropropenoate + cis-2-Hydroxy-3-chloropenta-2,4-dienone + H+." [UM-BBD_enzymeID:e0314]
xref: EC:3.7.1.-
xref: UM-BBD_enzymeID:e0314
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018771
name: 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase activity
namespace: molecular_function
alt_id: GO:0008680
def: "Catalysis of the reaction: 2-hydroxy-6-keto-nona-2,4-dienedioate + OH- = cis-2-hydroxypenta-2,4-dienoate + succinate." [UM-BBD_enzymeID:e0310]
xref: EC:3.7.1.-
xref: UM-BBD_enzymeID:e0310
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018772
name: trioxoheptanoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate." [MetaCyc:R306-RXN, UM-BBD_enzymeID:e0075]
xref: EC:3.7.1.-
xref: MetaCyc:R306-RXN
xref: UM-BBD_enzymeID:e0075
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018773
name: acetylpyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetylpyruvate + H2O = acetate + pyruvate." [EC:3.7.1.6]
synonym: "2,4-dioxopentanoate acetylhydrolase activity" EXACT [EC:3.7.1.6]
xref: EC:3.7.1.6
xref: MetaCyc:ACETYLPYRUVATE-HYDROLASE-RXN
xref: UM-BBD_enzymeID:e0076
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018774
name: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate." [EC:3.7.1.8]
subset: gosubset_prok
synonym: "2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase activity" EXACT [EC:3.7.1.8]
synonym: "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase activity" EXACT []
synonym: "HOHPDA hydrolase activity" EXACT [EC:3.7.1.8]
xref: EC:3.7.1.8
xref: MetaCyc:3.7.1.8-RXN
xref: UM-BBD_enzymeID:e0033
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018775
name: 2-hydroxymuconate-semialdehyde hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate." [EC:3.7.1.9]
synonym: "2-hydroxymuconate-semialdehyde formylhydrolase activity" EXACT [EC:3.7.1.9]
synonym: "2-hydroxymuconic semialdehyde hydrolase activity" EXACT [EC:3.7.1.9]
synonym: "HMSH" RELATED [EC:3.7.1.9]
synonym: "HOD hydrolase activity" EXACT [EC:3.7.1.9]
xref: EC:3.7.1.9
xref: MetaCyc:3.7.1.9-RXN
xref: UM-BBD_enzymeID:e0139
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0018776
name: trans-chloroacrylic acid dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde." [UM-BBD_enzymeID:e0434]
xref: EC:3.8.1.-
xref: UM-BBD_enzymeID:e0434
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018777
name: 1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol)." [PMID:10464214]
xref: EC:3.8.1.-
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018778
name: DL-2 haloacid dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trichloroacetate + 2 H2O = 3 H+ + 3 Cl- + oxalate." [UM-BBD_enzymeID:e0269]
xref: EC:3.8.1.-
xref: MetaCyc:RXN-9150
xref: UM-BBD_enzymeID:e0269
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018779
name: 2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
xref: EC:3.8.1.-
xref: UM-BBD_enzymeID:e0100
is_obsolete: true

[Term]
id: GO:0018780
name: dichloroacetate halidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate." [UM-BBD_enzymeID:e0268]
xref: EC:3.8.1.-
xref: UM-BBD_enzymeID:e0268
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018781
name: S-triazine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine -> 1-hydroxy-S-triazine." [UM-BBD_ruleID:bt0330]
xref: EC:3.8.1.-
xref: UM-BBD_enzymeID:e0091
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018782
name: cis-chloroacrylic acid dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde." [UM-BBD_enzymeID:e0433]
xref: EC:3.8.1.-
xref: UM-BBD_enzymeID:e0433
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018783
name: deisopropyldeethylatrazine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3." [UM-BBD_reactionID:0129]
xref: EC:3.8.1.-
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018784
name: (S)-2-haloacid dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [EC:3.8.1.2]
subset: gosubset_prok
synonym: "(S)-2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.2]
synonym: "2-haloacid dehalogenase activity" EXACT []
synonym: "2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.2]
synonym: "2-haloalkanoic acid dehalogenase activity" EXACT [EC:3.8.1.2]
synonym: "2-haloalkanoid acid halidohydrolase activity" EXACT [EC:3.8.1.2]
synonym: "2-halocarboxylic acid dehalogenase II activity" EXACT [EC:3.8.1.2]
synonym: "DL-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.2]
synonym: "halocarboxylic acid halidohydrolase activity" EXACT [EC:3.8.1.2]
synonym: "L-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.2]
synonym: "L-DEX activity" EXACT [EC:3.8.1.2]
xref: EC:3.8.1.2
xref: MetaCyc:2-HALOACID-DEHALOGENASE-RXN
xref: UM-BBD_enzymeID:e0021
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018785
name: haloacetate dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: haloacetate + H2O = glycolate + halide." [EC:3.8.1.3]
subset: gosubset_prok
synonym: "haloacetate halidohydrolase activity" EXACT [EC:3.8.1.3]
synonym: "monohaloacetate dehalogenase activity" EXACT [EC:3.8.1.3]
xref: EC:3.8.1.3
xref: MetaCyc:HALOACETATE-DEHALOGENASE-RXN
xref: UM-BBD_enzymeID:e0006
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018786
name: haloalkane dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide." [EC:3.8.1.5]
subset: gosubset_prok
synonym: "1-chlorohexane halidohydrolase activity" EXACT [EC:3.8.1.5]
synonym: "1-haloalkane dehalogenase activity" EXACT [EC:3.8.1.5]
synonym: "1-haloalkane halidohydrolase activity" EXACT [EC:3.8.1.5]
xref: EC:3.8.1.5
xref: MetaCyc:HALOALKANE-DEHALOGENASE-RXN
xref: UM-BBD_enzymeID:e0003
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018787
name: 4-chlorobenzoyl-CoA dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride." [EC:3.8.1.7]
synonym: "4-chlorobenzoyl CoA chlorohydrolase activity" EXACT [EC:3.8.1.7]
xref: EC:3.8.1.7
xref: MetaCyc:3.8.1.7-RXN
xref: UM-BBD_enzymeID:e0113
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018788
name: atrazine chlorohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: atrazine + H2O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride." [EC:3.8.1.8]
subset: gosubset_prok
synonym: "AtzA" RELATED [EC:3.8.1.8]
xref: EC:3.8.1.8
xref: MetaCyc:3.8.1.8-RXN
xref: UM-BBD_enzymeID:e0001
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0018789
name: cyclamate sulfohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexylsulfamate + H2O = cyclohexylamine + SO4(2-) (sulfate)." [EC:3.10.1.2]
synonym: "cyclamate sulfamatase activity" EXACT []
synonym: "cyclamate sulfamidase activity" EXACT [EC:3.10.1.2]
synonym: "cyclamate sulphohydrolase activity" EXACT []
synonym: "cyclohexylsulfamate sulfamidase activity" EXACT [EC:3.10.1.2]
synonym: "cyclohexylsulfamate sulfohydrolase activity" EXACT [EC:3.10.1.2]
xref: EC:3.10.1.2
xref: MetaCyc:CYCLAMATE-SULFOHYDROLASE-RXN
xref: UM-BBD_enzymeID:e0478
is_a: GO:0016826 ! hydrolase activity, acting on acid sulfur-nitrogen bonds

[Term]
id: GO:0018790
name: 2,3-dihydroxybenzoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + H+ = CO2 + catechol." [UM-BBD_enzymeID:e0383]
xref: EC:4.1.1.-
xref: MetaCyc:O-PYROCATECHUATE-DECARBOXYLASE-RXN
xref: UM-BBD_enzymeID:e0383
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018791
name: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate." [UM-BBD_enzymeID:e0286]
xref: EC:4.1.1.-
xref: UM-BBD_enzymeID:e0286
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018792
name: bis(4-chlorophenyl)acetate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM." [UM-BBD_enzymeID:e0355]
synonym: "DDA decarboxylase activity" EXACT []
xref: EC:4.1.1.-
xref: UM-BBD_enzymeID:e0355
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018793
name: 3,5-dibromo-4-hydroxybenzoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol." [UM-BBD_enzymeID:e0358]
xref: EC:4.1.1.-
xref: UM-BBD_enzymeID:e0358
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018794
name: 2-hydroxyisobutyrate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol." [UM-BBD_enzymeID:e0408]
xref: EC:4.1.1.-
xref: UM-BBD_enzymeID:e0408
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018795
name: 2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate." [UM-BBD_enzymeID:e0412]
xref: EC:4.1.1.-
xref: UM-BBD_enzymeID:e0412
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018796
name: 4,5-dihydroxyphthalate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2." [EC:4.1.1.55]
subset: gosubset_prok
synonym: "4,5-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" EXACT [EC:4.1.1.55]
synonym: "4,5-dihydroxyphthalate carboxy-lyase activity" EXACT [EC:4.1.1.55]
xref: EC:4.1.1.55
xref: MetaCyc:45-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN
xref: UM-BBD_enzymeID:e0106
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018798
name: gallate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4,5-trihydroxybenzoate = pyrogallol + CO2." [EC:4.1.1.59]
synonym: "gallate carboxy-lyase (pyrogallol-forming)" EXACT [EC:4.1.1.59]
synonym: "gallate carboxy-lyase activity" EXACT [EC:4.1.1.59]
synonym: "gallic acid decarboxylase activity" EXACT []
xref: EC:4.1.1.59
xref: MetaCyc:GALLATE-DECARBOXYLASE-RXN
xref: UM-BBD_enzymeID:e0008
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018799
name: 4-hydroxybenzoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybenzoate = phenol + CO2." [EC:4.1.1.61]
subset: gosubset_prok
synonym: "4-hydroxybenzoate carboxy-lyase (phenol-forming)" EXACT [EC:4.1.1.61]
synonym: "4-hydroxybenzoate carboxy-lyase activity" EXACT [EC:4.1.1.61]
synonym: "p-hydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.61]
xref: EC:4.1.1.61
xref: MetaCyc:4-HYDROXYBENZOATE-DECARBOXYLASE-RXN
xref: UM-BBD_enzymeID:e0138
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018800
name: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2." [EC:4.1.1.68]
subset: gosubset_prok
synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase activity" EXACT [EC:4.1.1.68]
synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase activity" EXACT []
synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)" EXACT [EC:4.1.1.68]
synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.68]
synonym: "HpaG-2" RELATED []
synonym: "HpaG2" RELATED []
synonym: "OPET decarboxylase activity" EXACT []
xref: EC:4.1.1.68
xref: MetaCyc:4.1.1.68-RXN
xref: UM-BBD_enzymeID:e0137
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018801
name: glutaconyl-CoA decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: pent-2-enoyl-CoA = but-2-enoyl-CoA + CO2." [EC:4.1.1.70]
subset: gosubset_prok
synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)" EXACT [EC:4.1.1.70]
synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.70]
synonym: "glutaconyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.70]
synonym: "pent-2-enoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.70]
xref: EC:4.1.1.70
xref: MetaCyc:GLUTACONYL-COA-DECARBOXYLASE-RXN
xref: UM-BBD_enzymeID:e0136
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018802
name: 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde." [UM-BBD_enzymeID:e0282]
xref: EC:4.1.2.-
xref: UM-BBD_enzymeID:e0282
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018803
name: 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate." [EC:4.1.2.34]
synonym: "(3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34]
synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.34]
synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34]
synonym: "2'-carboxybenzalpyruvate aldolase activity" EXACT [EC:4.1.2.34]
synonym: "trans-2'-carboxybenzalpyruvate hydratase-aldolase activity" EXACT []
xref: EC:4.1.2.34
xref: MetaCyc:4.1.2.34-RXN
xref: UM-BBD_enzymeID:e0330
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0018805
name: benzylsuccinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: fumarate + toluene = benzylsuccinate." [UM-BBD_enzymeID:e0259]
synonym: "benzylsuccinate fumarate-lyase (toluene-forming)" EXACT [EC:4.1.99.11]
synonym: "benzylsuccinate fumarate-lyase activity" EXACT [EC:4.1.99.11]
xref: EC:4.1.99.11
xref: MetaCyc:RXN-863
xref: UM-BBD_enzymeID:e0259
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0018807
name: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_enzymeID:e0185]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0185
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018808
name: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde." [UM-BBD_reactionID:r0484]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0327
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018809
name: E-phenylitaconyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA." [UM-BBD_enzymeID:e0262]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0262
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018810
name: trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene." [UM-BBD_enzymeID:e0164]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0164
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018811
name: cyclohex-1-ene-1-carboxyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA." [MetaCyc:R266-RXN, UM-BBD_enzymeID:e0175]
xref: EC:4.2.1.-
xref: MetaCyc:R266-RXN
xref: UM-BBD_enzymeID:e0175
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018812
name: 3-hydroxyacyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA)." [UM-BBD_ruleID:bt0291]
xref: EC:4.2.1.-
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018813
name: trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E )-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde)." [UM-BBD_enzymeID:e0257]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0257
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018814
name: phenylacetaldoxime dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (Z)-phenylacetaldehyde oxime = phenylacetonitrile + H2O." [EC:4.99.1.7, UM-BBD_enzymeID:e0437]
synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming) activity" EXACT [EC:4.99.1.7]
synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.7]
synonym: "arylacetaldoxime dehydratase activity" EXACT [EC:4.99.1.7]
synonym: "OxdB" RELATED [EC:4.99.1.7]
synonym: "PAOx dehydratase activity" EXACT [EC:4.99.1.7]
xref: EC:4.99.1.7
xref: MetaCyc:4.99.1.7-RXN
xref: UM-BBD_enzymeID:e0437
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0018815
name: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = CH2CHCOCOOH + 2,5,6-trihydroxy-3-methylpyridine." [MetaCyc:RXN-645, UM-BBD_enzymeID:e0045]
xref: EC:4.2.1.-
xref: MetaCyc:RXN-645
xref: UM-BBD_enzymeID:e0045
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018816
name: 2-hydroxyisobutyrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate." [UM-BBD_enzymeID:e0409]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0409
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018817
name: 2-oxo-hept-3-ene-1,7-dioate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate." [UM-BBD_enzymeID:e0281]
subset: gosubset_prok
synonym: "2-oxo-hepta-3-ene-1,7-dioate hydratase activity" EXACT []
synonym: "2-oxo-hepta-3-ene-1,7-dioic acid hydratase activity" EXACT []
synonym: "HpaH" RELATED []
xref: EC:4.2.1.-
xref: MetaCyc:HYDROXYHEPTA-DIENEDIOATE-HYDROXY-RXN
xref: UM-BBD_enzymeID:e0281
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018818
name: acetylene hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetaldehyde = acetylene + H2O." [EC:4.2.1.112, UM-BBD_enzymeID:e0394]
synonym: "acetaldehyde hydro-lyase activity" EXACT [EC:4.2.1.112]
synonym: "AH" RELATED [EC:4.2.1.112]
synonym: "AHy" RELATED [EC:4.2.1.112]
xref: EC:4.2.1.112
xref: MetaCyc:R141-RXN
xref: UM-BBD_enzymeID:e0394
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018819
name: lactoyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O." [EC:4.2.1.54]
synonym: "acrylyl coenzyme A hydratase activity" EXACT [EC:4.2.1.54]
synonym: "lactoyl coenzyme A dehydratase activity" EXACT [EC:4.2.1.54]
synonym: "lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)" EXACT [EC:4.2.1.54]
synonym: "lactoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.54]
synonym: "lactyl CoA dehydratase activity" EXACT [EC:4.2.1.54]
synonym: "lactyl-coenzyme A dehydrase activity" EXACT [EC:4.2.1.54]
xref: EC:4.2.1.54
xref: MetaCyc:LACTOYL-COA-DEHYDRATASE-RXN
xref: MetaCyc:RXN-781
xref: UM-BBD_enzymeID:e0070
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018820
name: cyanamide hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: urea = cyanamide + H2O." [EC:4.2.1.69]
synonym: "urea hydro-lyase (cyanamide-forming)" EXACT [EC:4.2.1.69]
synonym: "urea hydro-lyase activity" EXACT [EC:4.2.1.69]
xref: EC:4.2.1.69
xref: MetaCyc:CYANAMIDE-HYDRATASE-RXN
xref: UM-BBD_enzymeID:e0426
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018822
name: nitrile hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aliphatic amide = a nitrile + H2O." [EC:4.2.1.84]
subset: gosubset_prok
synonym: "3-cyanopyridine hydratase activity" EXACT [EC:4.2.1.84]
synonym: "acrylonitrile hydratase activity" EXACT [EC:4.2.1.84]
synonym: "aliphatic nitrile hydratase activity" EXACT [EC:4.2.1.84]
synonym: "aliphatic-amide hydro-lyase (nitrile-forming)" EXACT [EC:4.2.1.84]
synonym: "H-NHase activity" EXACT [EC:4.2.1.84]
synonym: "L-NHase activity" EXACT [EC:4.2.1.84]
synonym: "NHase activity" EXACT [EC:4.2.1.84]
synonym: "nitrile hydro-lyase activity" EXACT [EC:4.2.1.84]
xref: EC:4.2.1.84
xref: MetaCyc:NITRILE-HYDRATASE-RXN
xref: UM-BBD_enzymeID:e0067
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018823
name: cyclohexa-1,5-dienecarbonyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohex-1,5-dienecarbonyl-CoA + H2O = 6-hydroxycyclohex-1-ene-1-carbonyl-CoA." [EC:4.2.1.100]
subset: gosubset_prok
synonym: "6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming)" RELATED [EC:4.2.1.100]
synonym: "cyclohex-1,5-diene-1-carbonyl-CoA hydratase activity" EXACT []
synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA hydratase activity" EXACT [EC:4.2.1.100]
synonym: "cyclohexa-1,5-diene-1-carboxyl-CoA hydratase activity" EXACT [EC:4.2.1.100]
synonym: "cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.100]
synonym: "dienoyl-CoA hydratase activity" EXACT [EC:4.2.1.100]
xref: EC:4.2.1.100
xref: MetaCyc:4.2.1.100-RXN
xref: UM-BBD_enzymeID:e0184
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0018824
name: (hydroxyamino)benzene mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol." [EC:5.4.4.1, UM-BBD_enzymeID:e0246]
synonym: "(hydroxyamino)benzene hydroxymutase activity" EXACT [EC:5.4.4.1]
synonym: "HAB mutase activity" EXACT [EC:5.4.4.1]
synonym: "hydroxylaminobenzene hydroxymutase activity" EXACT [EC:5.4.4.1]
synonym: "hydroxylaminobenzene mutase activity" EXACT [EC:5.4.4.1]
xref: MetaCyc:5.4.4.1-RXN
xref: UM-BBD_enzymeID:e0246
is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups

[Term]
id: GO:0018825
name: triethanolamine lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde." [UM-BBD_enzymeID:e0421]
xref: EC:4.3.3.-
xref: UM-BBD_enzymeID:e0421
is_a: GO:0016843 ! amine-lyase activity

[Term]
id: GO:0018826
name: methionine gamma-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate." [EC:4.4.1.11]
subset: gosubset_prok
synonym: "L-methioninase activity" EXACT [EC:4.4.1.11]
synonym: "L-methionine gamma-lyase activity" EXACT [EC:4.4.1.11]
synonym: "L-methionine methanethiol-lyase (deaminating)" EXACT [EC:4.4.1.11]
synonym: "L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.11]
synonym: "methioninase activity" EXACT [EC:4.4.1.11]
synonym: "methionine dethiomethylase activity" EXACT [EC:4.4.1.11]
synonym: "methionine lyase activity" EXACT [EC:4.4.1.11]
xref: EC:4.4.1.11
xref: MetaCyc:METHIONINE-GAMMA-LYASE-RXN
xref: UM-BBD_enzymeID:e0305
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0018827
name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU." [UM-BBD_enzymeID:e0353]
synonym: "DDMS dehydrochlorinase activity" EXACT []
xref: EC:4.5.1.-
xref: UM-BBD_enzymeID:e0353
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0018828
name: halohydrin hydrogen-halide-lyase A activity
namespace: molecular_function
def: "Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0048]
xref: EC:4.5.1.-
xref: UM-BBD_enzymeID:e0048
is_a: GO:0019181 ! halohydrin hydrogen-halide-lyase activity

[Term]
id: GO:0018829
name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_enzymeID:e0351]
synonym: "DDD dehydrochlorinase activity" EXACT []
xref: EC:4.5.1.-
xref: UM-BBD_enzymeID:e0351
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0018830
name: gamma-hexachlorocyclohexane dehydrochlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene." [UM-BBD_enzymeID:e0359]
xref: EC:4.5.1.-
xref: UM-BBD_enzymeID:e0359
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0018831
name: 5-chloro-1,2,4-trihydroxybenzene dechlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone." [UM-BBD_enzymeID:e0425]
xref: EC:4.5.1.-
xref: UM-BBD_enzymeID:e0425
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0018832
name: halohydrin hydrogen-halide-lyase B activity
namespace: molecular_function
def: "Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0050]
xref: EC:4.5.1.-
xref: UM-BBD_enzymeID:e0050
is_a: GO:0019181 ! halohydrin hydrogen-halide-lyase activity

[Term]
id: GO:0018833
name: DDT-dehydrochlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + chloride." [EC:4.5.1.1]
synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming]" RELATED [EC:4.5.1.1]
synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase activity" EXACT [EC:4.5.1.1]
synonym: "DDT dehydrochlorinase activity" EXACT []
synonym: "DDT-as" RELATED [EC:4.5.1.1]
synonym: "DDT-ase activity" EXACT [EC:4.5.1.1]
synonym: "DDTase activity" EXACT [EC:4.5.1.1]
xref: EC:4.5.1.1
xref: MetaCyc:DDT-DEHYDROCHLORINASE-RXN
xref: UM-BBD_enzymeID:e0311
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0018834
name: dichloromethane dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dichloromethane + H2O = formaldehyde + 2 chloride." [EC:4.5.1.3]
subset: gosubset_prok
synonym: "dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)" EXACT [EC:4.5.1.3]
synonym: "dichloromethane chloride-lyase (chloride-hydrolysing)" EXACT [EC:4.5.1.3]
xref: EC:4.5.1.3
xref: MetaCyc:DICHLOROMETHANE-DEHALOGENASE-RXN
xref: UM-BBD_enzymeID:e0174
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0018835
name: carbon phosphorus lyase activity
namespace: molecular_function
alt_id: GO:0009456
def: "Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate)." [UM-BBD_enzymeID:e0057]
xref: EC:4.99.1.-
xref: UM-BBD_enzymeID:e0057
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0018836
name: alkylmercury lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: R-Hg+ + H+ = R-H + Hg2+." [EC:4.99.1.2]
subset: gosubset_prok
synonym: "alkylmercury mercuric-lyase (alkane-forming)" EXACT [EC:4.99.1.2]
synonym: "alkylmercury mercuric-lyase activity" EXACT [EC:4.99.1.2]
synonym: "organomercurial lyase activity" EXACT [EC:4.99.1.2]
synonym: "organomercury lyase activity" EXACT [EC:4.99.1.2]
xref: EC:4.99.1.2
xref: MetaCyc:ALKYLMERCURY-LYASE-RXN
xref: UM-BBD_enzymeID:e0055
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0018837
name: 2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate." [UM-BBD_enzymeID:e0344]
xref: EC:5.1.2.-
xref: UM-BBD_enzymeID:e0344
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0018838
name: mandelate racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-mandelate = (R)-mandelate." [EC:5.1.2.2]
subset: gosubset_prok
xref: EC:5.1.2.2
xref: MetaCyc:MANDELATE-RACEMASE-RXN
xref: UM-BBD_enzymeID:e0072
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0018839
name: cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_enzymeID:e0163]
xref: EC:5.2.1.-
xref: UM-BBD_enzymeID:e0163
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0018842
name: 3-carboxymuconate cycloisomerase type II activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-sulfomuconate = 4-sulfolactone." [UM-BBD_enzymeID:e0379]
subset: gosubset_prok
xref: EC:5.3.3.-
xref: UM-BBD_enzymeID:e0379
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0018844
name: 2-hydroxytetrahydrofuran isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde." [UM-BBD_enzymeID:e0026]
xref: EC:5.3.99.-
xref: UM-BBD_enzymeID:e0026
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0018845
name: 2-hydroxychromene-2-carboxylate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = trans-o-hydroxybenzylidenepyruvate." [UM-BBD_enzymeID:e0258]
xref: EC:5.3.99.-
xref: MetaCyc:RXNN-386
xref: UM-BBD_enzymeID:e0258
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0018846
name: styrene-oxide isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: styrene oxide = phenylacetaldehyde." [EC:5.3.99.7]
synonym: "SOI activity" EXACT [EC:5.3.99.7]
synonym: "styrene oxide isomerase activity" EXACT []
synonym: "styrene-oxide isomerase (epoxide-cleaving)" EXACT [EC:5.3.99.7]
xref: EC:5.3.99.7
xref: MetaCyc:STYRENE-OXIDE-ISOMERASE-RXN
xref: UM-BBD_enzymeID:e0196
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0018847
name: alpha-pinene lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-pinene = limonene." [UM-BBD_enzymeID:e0442]
xref: EC:5.5.1.-
xref: UM-BBD_enzymeID:e0442
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0018848
name: pinocarveol isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: pinocarveol = carveol." [UM-BBD_enzymeID:e0447]
xref: EC:5.5.1.-
xref: UM-BBD_enzymeID:e0447
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0018849
name: muconate cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate." [EC:5.5.1.1]
subset: gosubset_prok
synonym: "2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.1]
synonym: "4-carboxymethyl-4-hydroxyisocrotonolactone lyase (decyclizing)" EXACT [EC:5.5.1.1]
synonym: "cis,cis-muconate cycloisomerase activity" EXACT [EC:5.5.1.1]
synonym: "cis,cis-muconate lactonizing enzyme I activity" EXACT [EC:5.5.1.1]
synonym: "cis,cis-muconate-lactonizing enzyme" RELATED [EC:5.5.1.1]
synonym: "muconate cycloisomerase I activity" EXACT [EC:5.5.1.1]
synonym: "muconate lactonizing enzyme activity" EXACT [EC:5.5.1.1]
xref: EC:5.5.1.1
xref: MetaCyc:MUCONATE-CYCLOISOMERASE-RXN
xref: UM-BBD_enzymeID:e0133
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0018850
name: chloromuconate cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate." [EC:5.5.1.7]
subset: gosubset_prok
synonym: "2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.7]
synonym: "muconate cycloisomerase II activity" EXACT [EC:5.5.1.7]
xref: EC:5.5.1.7
xref: UM-BBD_enzymeID:e0065
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0018851
name: alpha-pinene-oxide decyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal." [EC:5.5.1.10]
synonym: "alpha-pinene oxide lyase activity" EXACT []
synonym: "alpha-pinene-oxide lyase (decyclizing)" EXACT [EC:5.5.1.10]
xref: EC:5.5.1.10
xref: MetaCyc:ALPHA-PINENE-OXIDE-DECYCLASE-RXN
xref: UM-BBD_enzymeID:e0471
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0018852
name: dichloromuconate cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate." [EC:5.5.1.11]
synonym: "2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.11]
xref: EC:5.5.1.11
xref: MetaCyc:DICHLOROMUCONATE-CYCLOISOMERASE-RXN
xref: UM-BBD_enzymeID:e0132
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0018853
name: perillyl-CoA synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + perillyl-CoA." [UM-BBD_enzymeID:e0460]
xref: EC:6.2.1.-
xref: UM-BBD_enzymeID:e0460
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018854
name: 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [UM-BBD_enzymeID:e0465]
xref: EC:6.2.1.-
xref: UM-BBD_enzymeID:e0465
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018855
name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA." [UM-BBD_enzymeID:e0303]
xref: EC:6.2.1.-
xref: UM-BBD_enzymeID:e0303
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018856
name: benzoyl acetate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoyl acetate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA." [UM-BBD_enzymeID:e0212]
xref: EC:6.2.1.-
xref: UM-BBD_enzymeID:e0212
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018857
name: 2,4-dichlorobenzoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA." [UM-BBD_enzymeID:e0110]
xref: EC:6.2.1.-
xref: UM-BBD_enzymeID:e0110
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018858
name: benzoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA. Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates." [EC:6.2.1.25]
subset: gosubset_prok
synonym: "benzoate-coenzyme A ligase activity" EXACT [EC:6.2.1.25]
synonym: "benzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.25]
synonym: "benzoyl CoA synthetase (AMP forming)" EXACT [EC:6.2.1.25]
synonym: "benzoyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.25]
xref: EC:6.2.1.25
xref: MetaCyc:BENZOATE--COA-LIGASE-RXN
xref: UM-BBD_enzymeID:e0131
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018859
name: 4-hydroxybenzoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA." [EC:6.2.1.27]
subset: gosubset_prok
synonym: "4-hydroxybenzoate-CoA synthetase activity" EXACT [EC:6.2.1.27]
synonym: "4-hydroxybenzoate-coenzyme A ligase (AMP-forming)" EXACT [EC:6.2.1.27]
synonym: "4-hydroxybenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.27]
synonym: "4-hydroxybenzoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.27]
synonym: "4-hydroxybenzoyl-CoA ligase activity" EXACT [EC:6.2.1.27]
xref: EC:6.2.1.27
xref: MetaCyc:4-HYDROXYBENZOATE--COA-LIGASE-RXN
xref: UM-BBD_enzymeID:e0130
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018860
name: anthranilate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA." [EC:6.2.1.32]
subset: gosubset_prok
synonym: "2-aminobenzoate coenzyme A ligase activity" EXACT [EC:6.2.1.32]
synonym: "2-aminobenzoate-CoA ligase activity" EXACT [EC:6.2.1.32]
synonym: "2-aminobenzoate-coenzyme A ligase activity" EXACT [EC:6.2.1.32]
synonym: "anthranilate--CoA ligase activity" EXACT []
synonym: "anthranilate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.32]
synonym: "anthraniloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.32]
xref: EC:6.2.1.32
xref: MetaCyc:AMINOBENZCOALIG-RXN
xref: UM-BBD_enzymeID:e0129
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018861
name: 4-chlorobenzoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. Requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway." [EC:6.2.1.33]
subset: gosubset_prok
synonym: "4-chlorobenzoate:CoA ligase activity" EXACT []
xref: EC:6.2.1.33
xref: MetaCyc:6.2.1.33-RXN
xref: UM-BBD_enzymeID:e0112
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0018862
name: phenylphosphate carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate." [UM-BBD_enzymeID:e0158]
xref: EC:6.4.1.-
xref: MetaCyc:PHENYLPCARB-RXN
xref: UM-BBD_enzymeID:e0158
is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds

[Term]
id: GO:0018863
name: phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene." [UM-BBD_enzymeID:e0335]
xref: EC:3.3.2.-
xref: UM-BBD_enzymeID:e0335
is_a: GO:0019119 ! phenanthrene-9,10-epoxide hydrolase activity

[Term]
id: GO:0018864
name: acetylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetylene, formula CH2CH2, the simplest of the alkynes." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "acetylene metabolism" EXACT []
synonym: "ethyne metabolic process" EXACT []
synonym: "ethyne metabolism" EXACT []
xref: UM-BBD_pathwayID:atl
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0043452 ! cellular alkyne metabolic process

[Term]
id: GO:0018865
name: acrylonitrile metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [http://www.iversonsoftware.com/reference/chemistry/a/acrylonitrile.htm]
subset: gosubset_prok
synonym: "acrylonitrile metabolism" EXACT []
xref: UM-BBD_pathwayID:acr
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0018866
name: adamantanone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai]
subset: gosubset_prok
synonym: "adamantanone metabolism" EXACT []
xref: UM-BBD_pathwayID:ada
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process

[Term]
id: GO:0018867
name: alpha-pinene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. It is a major component in tea-tree oils, and gives off a piney smelling odor." [http://umbbd.ahc.umn.edu/apn/apn_map.html, UM-BBD_pathwayID:apn]
subset: gosubset_prok
synonym: "alpha-pinene metabolism" EXACT []
xref: UM-BBD_pathwayID:apn
is_a: GO:0033073 ! pinene metabolic process

[Term]
id: GO:0018868
name: 2-aminobenzenesulfonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [http://umbbd.ahc.umn.edu/abs/abs_map.html, UM-BBD_pathwayID:abs]
subset: gosubset_prok
synonym: "2-aminobenzenesulfonate metabolism" EXACT []
synonym: "2-aminobenzenesulphonate metabolic process" EXACT []
synonym: "2-aminobenzenesulphonate metabolism" EXACT []
xref: UM-BBD_pathwayID:abs
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process

[Term]
id: GO:0018870
name: anaerobic 2-aminobenzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic 2-aminobenzoate metabolism" EXACT []
xref: UM-BBD_pathwayID:abz
is_a: GO:0018875 ! anaerobic benzoate metabolic process
is_a: GO:0043420 ! anthranilate metabolic process

[Term]
id: GO:0018871
name: 1-aminocyclopropane-1-carboxylate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [http://umbbd.ahc.umn.edu/acp/acp_map.html, UM-BBD_pathwayID:acp]
subset: gosubset_prok
synonym: "1-aminocyclopropane-1-carboxylate metabolism" EXACT []
synonym: "ACP metabolic process" EXACT []
synonym: "ACP metabolism" EXACT []
xref: UM-BBD_pathwayID:acp
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0044106 ! cellular amine metabolic process

[Term]
id: GO:0018872
name: arsonoacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides." [http://umbbd.ahc.umn.edu/ara/ara_map.html, UM-BBD_pathwayID:ara]
subset: gosubset_prok
synonym: "arsonoacetate metabolism" EXACT []
xref: UM-BBD_pathwayID:ara
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0018873
name: atrazine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide." [http://umbbd.ahc.umn.edu/atr/atr_map.html, UM-BBD_pathwayID:atr]
subset: gosubset_prok
synonym: "atrazine metabolism" EXACT []
xref: UM-BBD_pathwayID:atr
is_a: GO:0018965 ! s-triazine compound metabolic process
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018874
name: benzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "benzoate metabolism" EXACT []
xref: MetaCyc:P321-PWY
xref: UM-BBD_pathwayID:benz2
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process

[Term]
id: GO:0018875
name: anaerobic benzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic benzoate metabolism" EXACT []
xref: MetaCyc:CENTBENZCOA-PWY
xref: UM-BBD_pathwayID:benz
is_a: GO:0018874 ! benzoate metabolic process

[Term]
id: GO:0018876
name: benzonitrile metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzonitrile. Benzonitrile is used as a solvent and chemical intermediate in the pharmaceutical, dyestuffs and rubber industries. It is highly toxic and harmful in contact with skin." [UM-BBD_pathwayID:bzn]
subset: gosubset_prok
synonym: "benzonitrile metabolism" EXACT []
xref: UM-BBD_pathwayID:bzn
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0018877
name: beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:hch]
subset: gosubset_prok
synonym: "beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT []
xref: UM-BBD_pathwayID:hch
is_a: GO:0019497 ! hexachlorocyclohexane metabolic process

[Term]
id: GO:0018878
name: aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane that occur in presence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT []
is_a: GO:0018877 ! beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process

[Term]
id: GO:0018879
name: biphenyl metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs)." [GOC:jl]
subset: gosubset_prok
synonym: "biphenyl metabolism" EXACT []
synonym: "xenene metabolic process" EXACT []
synonym: "xenene metabolism" EXACT []
xref: UM-BBD_pathwayID:bph
is_a: GO:0042537 ! benzene and derivative metabolic process

[Term]
id: GO:0018880
name: 4-chlorobiphenyl metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-chlorobiphenyl, a member of the polychlorinated biphenyl (PCB) group of compounds, a very stable group of synthetic organic compounds composed of a biphenyl nucleus with 1-10 chlorine substituents. 4-chlorobiphenyl has been used as a model substrate to investigate PCB degradation." [GOC:jl]
subset: gosubset_prok
synonym: "4-chlorobiphenyl metabolism" EXACT []
xref: UM-BBD_pathwayID:cbp
is_a: GO:0018879 ! biphenyl metabolic process
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018881
name: bromoxynil metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bromoxynil, C7H3Br2NO, a dibrominated phenol derivative with a cyano (-CN) group attached. Bromoxynil is used as a herbicide for post-emergent control of annual broadleaf weeds and works by inhibiting photosynthesis in the target plants." [GOC:ai]
subset: gosubset_prok
synonym: "bromoxynil metabolism" EXACT []
xref: UM-BBD_pathwayID:box
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0018882
name: (+)-camphor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed." [http://umbbd.ahc.umn.edu/cam/cam_map.html, UM-BBD_pathwayID:cam]
subset: gosubset_prok
synonym: "(+)-camphor metabolism" EXACT []
synonym: "camphor metabolic process" EXACT []
synonym: "camphor metabolism" EXACT []
xref: UM-BBD_pathwayID:cam
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0043692 ! monoterpene metabolic process

[Term]
id: GO:0018883
name: caprolactam metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. It can cause local irritation." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "caprolactam metabolism" EXACT []
xref: UM-BBD_pathwayID:cap
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0018884
name: carbazole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:jl]
subset: gosubset_prok
synonym: "CAR metabolic process" EXACT []
synonym: "CAR metabolism" EXACT []
synonym: "carbazole metabolism" EXACT []
xref: UM-BBD_pathwayID:car
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0018885
name: carbon tetrachloride metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [http://umbbd.ahc.umn.edu/ctc/ctc_map.html, UM-BBD_pathwayID:ctc]
subset: gosubset_prok
synonym: "carbon tetrachloride metabolism" EXACT []
xref: Reactome:436263 "Dehalogenation of carbon tetrachloride to form a free radical"
xref: Reactome:458673 "Dehalogenation of carbon tetrachloride to form a free radical"
xref: Reactome:539646 "Dehalogenation of carbon tetrachloride to form a free radical"
xref: Reactome:76434 "Dehalogenation of carbon tetrachloride to form a free radical"
xref: UM-BBD_pathwayID:ctc
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018886
name: anaerobic carbon tetrachloride metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations, that occur in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic carbon tetrachloride metabolism" EXACT []
xref: UM-BBD_pathwayID:ctc
is_a: GO:0018885 ! carbon tetrachloride metabolic process

[Term]
id: GO:0018887
name: 4-carboxy-4'-sulfoazobenzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-carboxy-4'-sulfoazobenzene, a sulfonated azo compound synthesized by nitro-amine condensation from sulfanilic acid and 4-nitrobenzoic acid." [PMID:9603860]
subset: gosubset_prok
synonym: "4-carboxy-4'-sulfoazobenzene metabolism" EXACT []
synonym: "4-carboxy-4'-sulphoazobenzene metabolic process" EXACT []
synonym: "4-carboxy-4'-sulphoazobenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:csab
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0018888
name: 3-chloroacrylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-chloroacrylic acid, ClHC=CHCOOH, a chlorinated derivative of acrylic acid." [GOC:ai]
subset: gosubset_prok
synonym: "3-chloroacrylic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:caa
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018889
name: 2-chloro-N-isopropylacetanilide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [http://umbbd.ahc.umn.edu/ppc/ppc_map.html, UM-BBD_pathwayID:ppc]
subset: gosubset_prok
synonym: "2-chloro-N-isopropylacetanilide metabolism" EXACT []
synonym: "propachlor metabolic process" EXACT []
synonym: "propachlor metabolism" EXACT []
xref: UM-BBD_pathwayID:ppc
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process

[Term]
id: GO:0018890
name: cyanamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanamide, NCNH2, a cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "cyanamide metabolism" EXACT []
xref: UM-BBD_pathwayID:cnm
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0018891
name: cyclohexanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyclohexanol, the monohydroxy derivative of cyclohexane. It is used as a solvent and blending agent." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "cyclohexanol metabolism" EXACT []
xref: UM-BBD_pathwayID:chx
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0018892
name: cyclohexylsulfamate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyclohexylsulfamate, also known as cyclamic acid. Sodium cyclohexylsulfamate (CHS-Na) was a widely used sweetening agent but was banned because of the suspicion of carcinogenicity and metabolic conversion to cyclohexylamine (CHA), a toxic substance. It is now used as a fungicide." [UM-BBD_pathwayID:chs]
subset: gosubset_prok
synonym: "cyclohexylsulfamate metabolism" EXACT []
synonym: "cyclohexylsulphamate metabolic process" EXACT []
synonym: "cyclohexylsulphamate metabolism" EXACT []
xref: UM-BBD_pathwayID:chs
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0018893
name: dibenzofuran metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. Dibenzofuran is a white crystalline solid created from the production of coal tar and used as an insecticide and an intermediate in the production of other chemicals." [GOC:ai, UM-BBD_pathwayID:dbf]
subset: gosubset_prok
synonym: "dibenzofuran metabolism" EXACT []
xref: UM-BBD_pathwayID:dbf
is_a: GO:0018904 ! organic ether metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0018894
name: dibenzo-p-dioxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern." [UM-BBD_pathwayID:dpd]
subset: gosubset_prok
synonym: "dibenzo-p-dioxin metabolism" EXACT []
synonym: "oxanthrene metabolic process" EXACT []
synonym: "oxanthrene metabolism" EXACT []
synonym: "phenodioxin metabolic process" EXACT []
synonym: "phenodioxin metabolism" EXACT []
xref: UM-BBD_pathwayID:dpd
is_a: GO:0018904 ! organic ether metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0018895
name: dibenzothiophene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. Dibenzothiophene derivatives can be detected in diesel oil following hydrodesulfurization treatment to remove sulfur compounds that would otherwise generate sulfur oxides during combustion." [PMID:12147483]
subset: gosubset_prok
synonym: "dibenzothiophene metabolism" EXACT []
synonym: "diphenylene sulfide metabolic process" EXACT []
synonym: "diphenylene sulfide metabolism" EXACT []
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0018896
name: dibenzothiophene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai]
subset: gosubset_prok
synonym: "dibenzothiophene breakdown" EXACT []
synonym: "dibenzothiophene catabolism" EXACT []
synonym: "dibenzothiophene degradation" EXACT []
xref: UM-BBD_pathwayID:dbt2
is_a: GO:0018895 ! dibenzothiophene metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043451 ! alkene catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0018897
name: dibenzothiophene desulfurization
namespace: biological_process
def: "The removal of the sulfur atom from dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai]
subset: gosubset_prok
synonym: "dibenzothiophene desulphurization" EXACT []
xref: MetaCyc:PWY-681
xref: UM-BBD_pathwayID:dbt
is_a: GO:0018895 ! dibenzothiophene metabolic process

[Term]
id: GO:0018898
name: 2,4-dichlorobenzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:jl, http://umbbd.ahc.umn.edu/dcb/dcb_map.html, UM-BBD_pathwayID:dcb]
subset: gosubset_prok
synonym: "2,4-dichlorobenzoate metabolism" EXACT []
xref: UM-BBD_pathwayID:dcb
is_a: GO:0018874 ! benzoate metabolic process
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018899
name: 1,2-dichloroethane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:jl]
subset: gosubset_prok
synonym: "1,2-dichloroethane metabolism" EXACT []
xref: UM-BBD_pathwayID:dce
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018900
name: dichloromethane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dichloromethane, a dichlorinated derivative of methane. It is a colorless organic liquid with a sweet, chloroform-like odor, often used as a paint remover." [UM-BBD_pathwayID:dcm]
subset: gosubset_prok
synonym: "dichloromethane metabolism" EXACT []
xref: UM-BBD_pathwayID:dcm
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018901
name: 2,4-dichlorophenoxyacetic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [UM-BBD_pathwayID:2\,4d]
subset: gosubset_prok
synonym: "2,4-D metabolic process" EXACT []
synonym: "2,4-D metabolism" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:2\,4-d
is_a: GO:0018904 ! organic ether metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process

[Term]
id: GO:0018902
name: 1,3-dichloro-2-propanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. DCP is used as a general solvent, as an intermediate in organic synthesis and in paints, varnishes, lacquers, water colors, binders and photographic lacquers." [GOC:jl, http://umbbd.ahc.umn.edu/dcp/dcp_map.html, UM-BBD_pathwayID:dcp]
subset: gosubset_prok
synonym: "1,3-dichloro-2-propanol metabolism" EXACT []
synonym: "DCP metabolic process" EXACT []
synonym: "DCP metabolism" EXACT []
xref: UM-BBD_pathwayID:dcp
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018903
name: 1,3-dichloropropene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving members of the 1,3-dichloropropene family, which includes cis- and trans-1,3-dichloropropene. The 1,3-dichloropropenes are chlorinated hydrocarbons and the major active ingredients of commercial products for control of plant-parasitic nematodes." [http://umbbd.ahc.umn.edu/cpr/cpr_map.html, UM-BBD_pathwayID:cpr]
subset: gosubset_prok
synonym: "1,3-dichloropropene metabolism" EXACT []
synonym: "1,3-dichloropropylene metabolic process" EXACT []
synonym: "1,3-dichloropropylene metabolism" EXACT []
synonym: "gamma-chloroallylchloride metabolic process" EXACT []
synonym: "gamma-chloroallylchloride metabolism" EXACT []
xref: UM-BBD_pathwayID:cpr
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018904
name: organic ether metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "organic ether metabolism" EXACT []
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0018905
name: dimethyl ether metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dimethyl ether, CH3-O-CH3, the simplest ether. Dimethyl ether, also known wood ether and methyl ether, is a colorless gas that has been used in refrigeration applications." [UM-BBD_pathwayID:dme]
subset: gosubset_prok
synonym: "dimethyl ether metabolism" EXACT []
synonym: "methyl ether metabolic process" EXACT []
synonym: "methyl ether metabolism" EXACT []
xref: UM-BBD_pathwayID:dme
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0018904 ! organic ether metabolic process

[Term]
id: GO:0018906
name: methyl tert-butyl ether metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methyl tert-butyl ether, 2-methoxy-2-methylpropane. Methyl tert-butyl ether is a synthetic chemical which is mixed with gasoline for use in reformulated gasoline. It was first introduced as an additive for unleaded gasoline in the 1980s. It is also used as a laboratory reagent and a pharmaceutical agent." [UM-BBD_pathwayID:mtb]
subset: gosubset_prok
synonym: "methyl tert-butyl ether metabolism" EXACT []
xref: UM-BBD_pathwayID:mtb
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0018904 ! organic ether metabolic process

[Term]
id: GO:0018907
name: dimethyl sulfoxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dimethyl sulfoxide, DMSO (C2H6OS), an alkyl sulfoxide that is practically odorless in its purified form. As a highly polar organic liquid, it is a powerful solvent. Its biological activities include the ability to penetrate plant and animal tissues and to preserve living cells during freezing." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "dimethyl sulfoxide metabolism" EXACT []
synonym: "dimethyl sulphoxide metabolic process" EXACT []
synonym: "dimethyl sulphoxide metabolism" EXACT []
synonym: "DMSO metabolic process" EXACT []
synonym: "DMSO metabolism" EXACT []
xref: UM-BBD_pathwayID:sulf
is_a: GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0018908
name: organosulfide cycle
namespace: biological_process
subset: gosubset_prok
synonym: "organosulphide cycle" EXACT []
xref: UM-BBD_pathwayID:sulf
is_a: GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0018909
name: dodecyl sulfate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dodecyl sulfate, commonly found as sodium dodecyl sulfate (SDS), a component of a variety of synthetic surfactants." [UM-BBD_pathwayID:dds]
subset: gosubset_prok
synonym: "dodecyl sulfate metabolism" EXACT []
synonym: "dodecyl sulphate metabolic process" EXACT []
synonym: "dodecyl sulphate metabolism" EXACT []
xref: UM-BBD_pathwayID:dds
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0018910
name: benzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation." [GOC:ai, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "benzene metabolism" EXACT []
xref: Reactome:433010 "Benzene is hydroxylated to phenol"
xref: Reactome:455611 "Benzene is hydroxylated to phenol"
xref: Reactome:538824 "Benzene is hydroxylated to phenol"
xref: Reactome:76416 "Benzene is hydroxylated to phenol"
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0018911
name: 1,2,4-trichlorobenzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,2,4-trichlorobenzene, a derivative of benzene with chlorine atoms attached to positions 1, 2 and 4 of the ring. It is a colorless liquid used as a solvent in chemical manufacturing, in dyes and intermediates, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium and insecticides." [http://www.speclab.com/compound/c120821.htm]
subset: gosubset_prok
synonym: "1,2,4-trichlorobenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:tbz
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0018912
name: 1,4-dichlorobenzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. It forms white crystals at room temperature and is used as an insecticidal fumigant, particularly in mothballs." [http://www.speclab.com/compound/c106467.htm]
subset: gosubset_prok
synonym: "1,4-dichlorobenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:dcz
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0018913
name: anaerobic ethylbenzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring, that occur in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic ethylbenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:ethb
is_a: GO:0018915 ! ethylbenzene metabolic process

[Term]
id: GO:0018914
name: chlorobenzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chlorobenzene, a derivative of benzene with a chlorine atoms attached to the ring. It is a colorless liquid that is manufactured for use as a solvent. It quickly evaporates in the air and is degraded by hydroxyl radicals that are produced photochemically. The gas acts as a source of ClOx, which helps in the breakdown of stratospheric ozone." [http://www.shsu.edu/]
subset: gosubset_prok
synonym: "chlorobenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:cb
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0018915
name: ethylbenzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels." [http://www.speclab.com/compound/c100414.htm]
subset: gosubset_prok
synonym: "ethylbenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:ethb2
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0018916
name: nitrobenzene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "nitrobenzene metabolism" EXACT []
xref: UM-BBD_pathwayID:nb
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0018917
name: fluorene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [http://umbbd.ahc.umn.edu/flu/flu_map.html, UM-BBD_pathwayID:flu]
subset: gosubset_prok
synonym: "fluorene metabolism" EXACT []
xref: UM-BBD_pathwayID:flu
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0018918
name: gallate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid). The esters and polyesters are widely distributed in angiosperms." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "gallate metabolism" EXACT []
synonym: "gallic acid metabolic process" EXACT []
synonym: "gallic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:gal
is_a: GO:0009712 ! catechol metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0018919
name: gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gamma-1,2,3,4,5,6-hexachlorocyclohexane (also known as Lindane), the most common form of hexachlorohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:ghch]
subset: gosubset_prok
synonym: "gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT []
xref: MetaCyc:GAMMAHEXCHLORDEG-PWY
xref: UM-BBD_pathwayID:ghch
is_a: GO:0019497 ! hexachlorocyclohexane metabolic process

[Term]
id: GO:0018920
name: glyphosate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glyphosate, a broad-spectrum herbicide also known by the trade name Roundup. It is a member of a broad class of compounds known as phosphonic acids, which contain a direct carbon-to-phosphorus (C-P) bond." [http://umbbd.ahc.umn.edu/gly/gly_map.html, UM-BBD_pathwayID:gly]
subset: gosubset_prok
synonym: "glyphosate metabolism" EXACT []
synonym: "Roundup metabolic process" EXACT []
synonym: "Roundup metabolism" EXACT []
xref: UM-BBD_pathwayID:gly
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0018921
name: 3-hydroxybenzyl alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-hydroxybenzyl alcohol, an aromatic compound which is an intermediate in several metabolic pathways, including the biosynthesis of patulin, a toxin and antiviral agent produced by some moulds such as Penicillium patulinum." [http://umbbd.ahc.umn.edu/mcr/mcr_map.html, UM-BBD_pathwayID:mcr]
subset: gosubset_prok
synonym: "3-hydroxybenzyl alcohol metabolism" EXACT []
xref: UM-BBD_pathwayID:mcr
is_a: GO:0018958 ! phenol metabolic process

[Term]
id: GO:0018922
name: iprodione metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prodione, a colorless, odorless crystal. It is used as a dicarboximide contact fungicide to control a wide variety of crop diseases by inhibiting the germination of spores and the growth of the fungal mat (mycelium)." [http://umbbd.ahc.umn.edu/ipd/ipd_map.html, UM-BBD_pathwayID:ipd]
subset: gosubset_prok
synonym: "iprodione metabolism" EXACT []
xref: UM-BBD_pathwayID:ipd
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0018923
name: limonene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [http://umbbd.ahc.umn.edu/lim/lim_map.html, UM-BBD_pathwayID:lim]
subset: gosubset_prok
synonym: "limonene metabolism" EXACT []
xref: UM-BBD_pathwayID:lim
is_a: GO:0043692 ! monoterpene metabolic process

[Term]
id: GO:0018924
name: mandelate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:jl]
subset: gosubset_prok
synonym: "mandelate metabolism" EXACT []
synonym: "mandelic acid metabolic process" EXACT []
synonym: "mandelic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:mca
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0018925
name: m-cresol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving m-cresol (3-hydroxytoluene), the meta-isoform of cresol. Used to produce agricultural chemicals, and in specialty resins, pharmaceuticals and pressure-sensitive dyes." [GOC:jl]
subset: gosubset_prok
synonym: "3-hydroxytoluene metabolic process" EXACT []
synonym: "3-hydroxytoluene metabolism" EXACT []
synonym: "m-cresol metabolism" EXACT []
synonym: "meta-cresol metabolic process" EXACT []
synonym: "meta-cresol metabolism" EXACT []
xref: MetaCyc:M-CRESOL-DEGRADATION-PWY
xref: UM-BBD_pathwayID:mcr
is_a: GO:0042212 ! cresol metabolic process

[Term]
id: GO:0018926
name: methanesulfonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methanesulfonic acid, a strong acid produced by the oxidation of dimethyl sulfide." [UM-BBD_pathwayID:msa]
subset: gosubset_prok
synonym: "methanesulfonic acid metabolism" EXACT []
synonym: "methanesulphonic acid metabolic process" EXACT []
synonym: "methanesulphonic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:msa
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0018927
name: methionine and threonine metabolic process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because its use of 'and' was causing violations to the true-path rule.
is_obsolete: true
consider: GO:0006555
consider: GO:0006566

[Term]
id: GO:0018928
name: methyl ethyl ketone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints." [http://umbbd.ahc.umn.edu/mek/mek_map.html, UM-BBD_pathwayID:mek]
subset: gosubset_prok
synonym: "2-butanone metabolic process" EXACT []
synonym: "2-butanone metabolism" EXACT []
synonym: "MEK metabolic process" EXACT []
synonym: "MEK metabolism" EXACT []
synonym: "methyl ethyl ketone metabolism" EXACT []
xref: UM-BBD_pathwayID:mek
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process

[Term]
id: GO:0018929
name: methyl fluoride metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methyl fluoride, fluorine-substituted methane, a gaseous halogenated hydrocarbon that has been investigated as an inhibitor of methanotrophy and nitrification in soils." [UM-BBD_pathwayID:mf]
subset: gosubset_prok
synonym: "methyl fluoride metabolism" EXACT []
xref: UM-BBD_pathwayID:mf
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process

[Term]
id: GO:0018930
name: 3-methylquinoline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring." [GOC:ai]
subset: gosubset_prok
synonym: "3-methylquinoline metabolism" EXACT []
xref: UM-BBD_pathwayID:mqn
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0018931
name: naphthalene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving naphthalene, a fused ring bicyclic aromatic hydrocarbon commonly found in crude oil and oil products. Naphthalene is familiar as the compound that gives mothballs their odor; it is used in the manufacture of plastics, dyes, solvents, and other chemicals, as well as being used as an antiseptic and insecticide." [http://www.iversonsoftware.com/reference/chemistry/n/Naphthalene.htm]
subset: gosubset_prok
synonym: "naphthalene metabolism" EXACT []
xref: UM-BBD_pathwayID:naph
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0018933
name: nicotine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684]
subset: gosubset_prok
synonym: "nicotine metabolism" EXACT []
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0018934
name: nitrilotriacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrilotriacetate, an aminotricarboxylic acid that binds bivalent metal ions in a ratio of 1:1. As an important industrial chelating agent, NTA has been widely used for various radionuclide processing and decontamination procedures, such as textile, paper and pulp processing and water treatment." [UM-BBD_pathwayID:nta]
subset: gosubset_prok
synonym: "nitrilotriacetate metabolism" EXACT []
xref: UM-BBD_pathwayID:nta
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0018935
name: aerobic nitrilotriacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the presence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "aerobic nitrilotriacetate metabolism" EXACT []
is_a: GO:0018934 ! nitrilotriacetate metabolic process

[Term]
id: GO:0018936
name: anaerobic nitrilotriacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic nitrilotriacetate metabolism" EXACT []
is_a: GO:0018934 ! nitrilotriacetate metabolic process

[Term]
id: GO:0018937
name: nitroglycerin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitroglycerin, a well-known nitrate ester and an important component of dynamite and other propellants. Toxic to algae, invertebrate, and vertebrates." [http://umbbd.ahc.umn.edu/ng/ng_map.html, UM-BBD_pathwayID:ng]
subset: gosubset_prok
synonym: "NG metabolic process" EXACT []
synonym: "NG metabolism" EXACT []
synonym: "nitroglycerin metabolism" EXACT []
xref: MetaCyc:P201-PWY
xref: UM-BBD_pathwayID:ng
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0018938
name: 2-nitropropane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. 2-nitropropane is used principally as a solvent and chemical intermediate. As a solvent, it is used in inks, paints, adhesives, varnishes, polymers, and synthetic materials. It is a feedstock for the manufacture of 2-nitro-2-methyl-1-propanol and 2-amino-2-methyl-1-propanol." [http://umbbd.ahc.umn.edu/npp/npp_map.html, UM-BBD_pathwayID:npp]
subset: gosubset_prok
synonym: "2-nitropropane metabolism" EXACT []
xref: MetaCyc:PWY-723
xref: UM-BBD_pathwayID:npp
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0043446 ! cellular alkane metabolic process

[Term]
id: GO:0018939
name: n-octane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving n-octane, the 8 carbon straight chain alkane used in organic syntheses, calibrations, and azeotropic distillations. It is a common component of gasoline and other petroleum products and the engine fuel antiknocking properties of an isomer of n-octane are used as a comparative standard in the Octane Rating System." [UM-BBD_pathwayID:oct]
subset: gosubset_prok
synonym: "n-octane metabolism" EXACT []
xref: UM-BBD_pathwayID:oct
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0043446 ! cellular alkane metabolic process

[Term]
id: GO:0018940
name: orcinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen, and synthesized, probably as a fungicide, by some higher plants." [GOC:jl]
subset: gosubset_prok
synonym: "orcin metabolic process" EXACT []
synonym: "orcin metabolism" EXACT []
synonym: "orcinol metabolism" EXACT []
xref: MetaCyc:P342-PWY
xref: UM-BBD_pathwayID:orc
is_a: GO:0018958 ! phenol metabolic process
is_a: GO:0018970 ! toluene metabolic process
is_a: GO:0034311 ! diol metabolic process

[Term]
id: GO:0018941
name: organomercury metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organomercury compound, any organic compound containing a mercury atom." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "organomercury metabolism" EXACT []
xref: UM-BBD_pathwayID:ogm
is_a: GO:0018942 ! organometal metabolic process

[Term]
id: GO:0018942
name: organometal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organometals, any metal-containing organic compound, especially one in which the metal atom is linked directly to one of more carbon atoms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
synonym: "organometal metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0018943
name: organotin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organotin, an organic compound containing a tin atom." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "organotin metabolism" EXACT []
is_a: GO:0018942 ! organometal metabolic process

[Term]
id: GO:0018944
name: tri-n-butyltin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tri-n-butyltin, an organometallic compound composed of three butyl chains attached to a tin atom. Tri-n-butyltin is used as an antifouling agent in ship bottom paints and can be toxic to many marine organisms." [GOC:ai, UM-BBD_pathwayID:tbt]
subset: gosubset_prok
synonym: "tri-n-butyltin metabolism" EXACT []
xref: UM-BBD_pathwayID:tbt
is_a: GO:0018943 ! organotin metabolic process

[Term]
id: GO:0018945
name: organosilicon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any organosilicon, organic compounds that contain silicon, a nonmetal element analogous to carbon." [GOC:jl]
subset: gosubset_prok
synonym: "organosilicon metabolism" EXACT []
synonym: "organosilicone metabolic process" EXACT []
synonym: "organosilicone metabolism" EXACT []
xref: UM-BBD_pathwayID:osi
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0018946
name: aerobic organosilicon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the presence of oxygen." [GOC:jl]
subset: gosubset_prok
synonym: "aerobic organosilicon metabolism" EXACT []
synonym: "aerobic organosilicone metabolic process" EXACT []
synonym: "aerobic organosilicone metabolism" EXACT []
xref: UM-BBD_pathwayID:osi
is_a: GO:0018945 ! organosilicon metabolic process

[Term]
id: GO:0018947
name: anaerobic organosilicon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the absence of oxygen." [GOC:jl]
subset: gosubset_prok
synonym: "anaerobic organosilicon metabolism" EXACT []
synonym: "anaerobic organosilicone metabolic process" EXACT []
synonym: "anaerobic organosilicone metabolism" EXACT []
xref: UM-BBD_pathwayID:osi
is_a: GO:0018945 ! organosilicon metabolic process

[Term]
id: GO:0018948
name: xylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:jl]
subset: gosubset_prok
synonym: "xylene metabolism" EXACT []
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0018949
name: m-xylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving m-xylene, (1,3-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl]
subset: gosubset_prok
synonym: "m-xylene metabolism" EXACT []
synonym: "meta-xylene metabolic process" EXACT []
synonym: "meta-xylene metabolism" EXACT []
xref: UM-BBD_pathwayID:mxy
is_a: GO:0018948 ! xylene metabolic process

[Term]
id: GO:0018950
name: o-xylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl]
subset: gosubset_prok
synonym: "o-xylene metabolism" EXACT []
synonym: "ortho-xylene metabolic process" EXACT []
synonym: "ortho-xylene metabolism" EXACT []
xref: UM-BBD_pathwayID:oxy
is_a: GO:0018948 ! xylene metabolic process

[Term]
id: GO:0018951
name: p-xylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving p-xylene, (1,4-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl]
subset: gosubset_prok
synonym: "p-xylene metabolism" EXACT []
synonym: "para-xylene metabolic process" EXACT []
synonym: "para-xylene metabolism" EXACT []
xref: UM-BBD_pathwayID:pxy
is_a: GO:0018948 ! xylene metabolic process

[Term]
id: GO:0018952
name: parathion metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [http://umbbd.ahc.umn.edu/pthn/pthn_map.html, UM-BBD_pathwayID:pthn]
subset: gosubset_prok
synonym: "parathion metabolism" EXACT []
xref: UM-BBD_pathwayID:pthn
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0019637 ! organophosphate metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process

[Term]
id: GO:0018953
name: p-cymene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants." [UM-BBD_pathwayID:pcy]
subset: gosubset_prok
synonym: "p-cymene metabolism" EXACT []
xref: UM-BBD_pathwayID:pcy
is_a: GO:0018970 ! toluene metabolic process

[Term]
id: GO:0018954
name: pentaerythritol tetranitrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentaerythritol tetranitrate, C(CH2-O-NO2)4, a substance produced for use as an explosive and a vasodilator." [UM-BBD_pathwayID:petn]
subset: gosubset_prok
synonym: "pentaerythritol tetranitrate metabolism" EXACT []
xref: UM-BBD_pathwayID:petn
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0018955
name: phenanthrene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phenanthrene, a tricyclic aromatic hydrocarbon used in explosives and in the synthesis of dyes and drugs. Although phenanthrene is not mutagenic or carcinogenic, it has been shown to be toxic to marine diatoms, gastropods, mussels, crustaceans, and fish." [GOC:jl, http://umbbd.ahc.umn.edu/pha/pha_map.html, UM-BBD_pathwayID:pha]
subset: gosubset_prok
synonym: "phenanthrene metabolism" EXACT []
xref: UM-BBD_pathwayID:pha
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0018956
name: phenanthrene catabolic process via trans-9(R),10(R)-dihydrodiolphenanthrene
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(R),10(R)-dihydrodiolphenanthrene is the principal intermediate metabolite." [http://umbbd.ahc.umn.edu/pha3/pha3_map.html, UM-BBD_pathwayID:pha3]
subset: gosubset_prok
synonym: "phenanthrene breakdown via trans-9(R),10(R)-dihydrodiolphenanthrene" EXACT []
synonym: "phenanthrene degradation via trans-9(R),10(R)-dihydrodiolphenanthrene" EXACT []
xref: UM-BBD_pathwayID:pha3
is_a: GO:0042216 ! phenanthrene catabolic process

[Term]
id: GO:0018957
name: phenanthrene catabolic process via trans-9(S),10(S)-dihydrodiolphenanthrene
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(S),10(S)-dihydrodiolphenanthrene is the principal intermediate metabolite." [http://umbbd.ahc.umn.edu/pha2/pha2_map.html, UM-BBD_pathwayID:pha2]
subset: gosubset_prok
synonym: "phenanthrene breakdown via trans-9(S),10(S)-dihydrodiolphenanthrene" EXACT []
synonym: "phenanthrene degradation via trans-9(S),10(S)-dihydrodiolphenanthrene" EXACT []
xref: UM-BBD_pathwayID:pha2
is_a: GO:0042216 ! phenanthrene catabolic process

[Term]
id: GO:0018958
name: phenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. The largest single use of phenol is in the production of plastics, but it is also used in the synthesis of caprolactam, a precursor for nylon 6 and other man-made fibers." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds.
subset: gosubset_prok
synonym: "carbolic acid metabolic process" EXACT []
synonym: "carbolic acid metabolism" EXACT []
synonym: "hydroxybenzene metabolic process" EXACT []
synonym: "hydroxybenzene metabolism" EXACT []
synonym: "phenol metabolism" EXACT []
xref: UM-BBD_pathwayID:phe
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0006725 ! cellular aromatic compound metabolic process

[Term]
id: GO:0018959
name: aerobic phenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aerobic carbolic acid metabolic process" EXACT []
synonym: "aerobic carbolic acid metabolism" EXACT []
synonym: "aerobic hydroxybenzene metabolic process" EXACT []
synonym: "aerobic hydroxybenzene metabolism" EXACT []
synonym: "aerobic phenol metabolism" EXACT []
xref: UM-BBD_pathwayID:phe
is_a: GO:0018958 ! phenol metabolic process

[Term]
id: GO:0018960
name: 4-nitrophenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:jl]
subset: gosubset_prok
synonym: "4-nitrophenol metabolism" EXACT []
synonym: "p-nitrophenol metabolic process" EXACT []
synonym: "p-nitrophenol metabolism" EXACT []
xref: UM-BBD_pathwayID:nphe
is_a: GO:0018958 ! phenol metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process

[Term]
id: GO:0018961
name: pentachlorophenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [http://umbbd.ahc.umn.edu/pcp/pcp_map.html, UM-BBD_pathwayID:pcp]
subset: gosubset_prok
synonym: "PCP metabolic process" EXACT []
synonym: "PCP metabolism" EXACT []
synonym: "pentachlorophenol metabolism" EXACT []
xref: UM-BBD_pathwayID:pcp
is_a: GO:0018958 ! phenol metabolic process
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018962
name: 3-phenylpropionate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-phenylpropionate, the anion of phenylpropanoic acid. It is produced from putrefaction of proteins in soil or breakdown of several constituents of plants, such as lignin, various oils and resins." [GOC:ai, UM-BBD_pathwayID:ppa]
subset: gosubset_prok
synonym: "3-phenylpropionate metabolism" EXACT []
synonym: "hydrocinnamic acid metabolic process" EXACT []
synonym: "hydrocinnamic acid metabolism" EXACT []
synonym: "phenylpropanoate metabolic process" EXACT []
synonym: "phenylpropanoate metabolism" EXACT []
xref: UM-BBD_pathwayID:ppa
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process

[Term]
id: GO:0018963
name: phthalate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phthalate, the anion of phthalic acid. Phthalic acid diesters are used industrially in the production of a variety of household and consumer goods including plastic polymers, lubricating oils, and carriers for perfumes in cosmetics, while phthalic acid itself is used industrially as a plasticizer. Terephthalate is used in the synthesis of polyethylene terephthalate (polyethene terephthlate, abbreviated PET or PETE), a plastic polymer with many commercial uses." [http://umbbd.ahc.umn.edu/pth/pth_map.html, UM-BBD_pathwayID:pth]
subset: gosubset_prok
synonym: "phthalate metabolism" EXACT []
synonym: "phthalic acid metabolic process" EXACT []
synonym: "phthalic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:pth
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0018964
name: propylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals." [GOC:jl]
subset: gosubset_prok
synonym: "propylene metabolism" EXACT []
xref: UM-BBD_pathwayID:pro
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0018965
name: s-triazine compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms." [http://umbbd.ahc.umn.edu/tria/tria_map.html, UM-BBD_pathwayID:tria]
subset: gosubset_prok
synonym: "s-triazine compound metabolism" EXACT []
xref: UM-BBD_pathwayID:tria
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0018966
name: styrene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving styrene, an aromatic hydrocarbon liquid soluble in ether and alcohol. When heated, exposed to light or added to a peroxide catalyst, it undergoes polymerization to form polystyrene, a versatile material used in the manufacture of plastics, synthetic rubber, thermal insulation, and packaging. Styrene is a classified mutagen and a suspected carcinogen." [GOC:jl, http://umbbd.ahc.umn.edu/sty/sty_map.html, UM-BBD_pathwayID:sty]
subset: gosubset_prok
synonym: "styrene metabolism" EXACT []
xref: UM-BBD_pathwayID:sty
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0018967
name: tetrachloroethylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrachloroethylene (tetrachloroethene), a derivative of ethene with the hydrogen atoms replaced by chlorines. Tetrachloroethene has been used primarily as a solvent in dry-cleaning industries and to a lesser extent as a degreasing solvent." [http://www.who.int/water_sanitation_health/GDWQ/Chemicals/tetrachloroethenesum.htm]
subset: gosubset_prok
synonym: "tetrachloroethene metabolic process" EXACT []
synonym: "tetrachloroethene metabolism" EXACT []
synonym: "tetrachloroethylene metabolism" EXACT []
xref: UM-BBD_pathwayID:tce2
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0018968
name: tetrahydrofuran metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrahydrofuran, a cyclic 4 carbon ether. It is one of the most polar ethers and is a widely used solvent for polar reagents. Since THF is very soluble in water and has a relatively low boiling point, significant amounts are often released into the environment, causing contamination problems." [UM-BBD_pathwayID:thf]
subset: gosubset_prok
synonym: "tetrahydrofuran metabolism" EXACT []
synonym: "THF metabolic process" EXACT []
synonym: "THF metabolism" EXACT []
xref: UM-BBD_pathwayID:thf
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0018904 ! organic ether metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0018969
name: thiocyanate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thiocyanate, the anion of thiocyanic acid, a toxic cyanide derivative commonly formed as a by-product in the production of gas for fuel, coke, and substances for chemical industries." [GOC:jl]
subset: gosubset_prok
synonym: "thiocyanate metabolism" EXACT []
synonym: "thiocyanic acid metabolic process" EXACT []
synonym: "thiocyanic acid metabolism" EXACT []
xref: MetaCyc:P581-PWY
xref: UM-BBD_pathwayID:thc
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0018970
name: toluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications." [http://umbbd.ahc.umn.edu/tol/tol_map.html, UM-BBD_pathwayID:tol]
subset: gosubset_prok
synonym: "methylbenzene metabolic process" EXACT []
synonym: "methylbenzene metabolism" EXACT []
synonym: "toluene metabolism" EXACT []
is_a: GO:0042537 ! benzene and derivative metabolic process
is_a: GO:0043449 ! cellular alkene metabolic process

[Term]
id: GO:0018971
name: anaerobic toluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, that occur in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic toluene metabolism" EXACT []
xref: UM-BBD_pathwayID:tol2
is_a: GO:0018970 ! toluene metabolic process

[Term]
id: GO:0018972
name: toluene-4-sulfonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving toluene-4-sulfonate, the anion of 4-toluene sulfonic acid, a white crystalline solid which is highly hygroscopic and soluble in water." [GOC:ai]
subset: gosubset_prok
synonym: "4-methylbenzenesulfonate metabolic process" EXACT []
synonym: "4-methylbenzenesulfonate metabolism" EXACT []
synonym: "4-toluenesulfonate metabolic process" EXACT []
synonym: "4-toluenesulfonate metabolism" EXACT []
synonym: "toluene-4-sulfonate metabolism" EXACT []
synonym: "toluene-4-sulphonate metabolic process" EXACT []
synonym: "toluene-4-sulphonate metabolism" EXACT []
xref: MetaCyc:TOLSULFDEG-PWY
xref: UM-BBD_pathwayID:tsa
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0018970 ! toluene metabolic process

[Term]
id: GO:0018973
name: trinitrotoluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai]
subset: gosubset_prok
synonym: "trinitrotoluene metabolism" EXACT []
xref: UM-BBD_pathwayID:tnt
is_a: GO:0019326 ! nitrotoluene metabolic process

[Term]
id: GO:0018974
name: 2,4,6-trinitrotoluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. It is prepared from toluene treated with concentrated sulfuric and nitric acids and is used in shells, bombs, and blasting explosives." [ISBN:0333781767]
subset: gosubset_prok
synonym: "2,4,6-trinitrotoluene metabolism" EXACT []
synonym: "TNT metabolic process" EXACT []
synonym: "TNT metabolism" EXACT []
is_a: GO:0018973 ! trinitrotoluene metabolic process

[Term]
id: GO:0018975
name: anaerobic 2,4,6-trinitrotoluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, that occur in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic 2,4,6-trinitrotoluene metabolism" EXACT []
xref: UM-BBD_pathwayID:tnt2
is_a: GO:0018971 ! anaerobic toluene metabolic process
is_a: GO:0018974 ! 2,4,6-trinitrotoluene metabolic process

[Term]
id: GO:0018976
name: 1,2,3-tribromopropane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,2,3-tribromopropane, a toxic and volatile organic compound commonly used as a nematocide in agriculture." [GOC:jl]
subset: gosubset_prok
synonym: "1,2,3-tribromopropane metabolism" EXACT []
xref: UM-BBD_pathwayID:tbp
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process

[Term]
id: GO:0018977
name: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GOC:jl]
subset: gosubset_prok
synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism" EXACT []
synonym: "DDT metabolic process" EXACT []
synonym: "DDT metabolism" EXACT []
xref: UM-BBD_pathwayID:ddt
is_a: GO:0017143 ! insecticide metabolic process
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process
relationship: part_of GO:0046680 ! response to DDT

[Term]
id: GO:0018978
name: anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated, broad spectrum, contact insecticide, in the absence of oxygen." [GOC:jl]
subset: gosubset_prok
synonym: "anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism" EXACT []
synonym: "anaerobic DDT metabolic process" EXACT []
synonym: "anaerobic DDT metabolism" EXACT []
xref: UM-BBD_pathwayID:ddt2
is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process

[Term]
id: GO:0018979
name: trichloroethylene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent." [GOC:jl]
subset: gosubset_prok
synonym: "TCE metabolic process" EXACT []
synonym: "TCE metabolism" EXACT []
synonym: "trichloroethene metabolic process" EXACT []
synonym: "trichloroethene metabolism" EXACT []
synonym: "trichloroethylene metabolism" EXACT []
xref: UM-BBD_pathwayID:tce
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0018980
name: 2,4,5-trichlorophenoxyacetic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound which is widely used as a herbicide, often as a weed killer for home lawns." [UM-BBD_pathwayID:2\,4\,5-t]
subset: gosubset_prok
synonym: "2,4,5-T metabolic process" EXACT []
synonym: "2,4,5-T metabolism" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid metabolism" EXACT []
xref: UM-BBD_pathwayID:2\,4\,5-t
is_a: GO:0018904 ! organic ether metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process

[Term]
id: GO:0018981
name: triethanolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:jl]
subset: gosubset_prok
synonym: "triethanolamine metabolism" EXACT []
xref: UM-BBD_pathwayID:tea
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0042439 ! ethanolamine and derivative metabolic process

[Term]
id: GO:0018982
name: vanillin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods and can be obtained as a by-product of the pulp and paper industry by the oxidative breakdown of lignin." [GOC:jl]
subset: gosubset_prok
synonym: "vanillic aldehyde metabolic process" EXACT []
synonym: "vanillic aldehyde metabolism" EXACT []
synonym: "vanillin metabolism" EXACT []
xref: UM-BBD_pathwayID:van
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0006725 ! cellular aromatic compound metabolic process

[Term]
id: GO:0018983
name: Z-phenylacetaldoxime metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants." [http://umbbd.ahc.umn.edu/car/car_map.html, UM-BBD_pathwayID:car]
subset: gosubset_prok
synonym: "Z-phenylacetaldoxime metabolism" EXACT []
xref: UM-BBD_pathwayID:pao
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0019330 ! aldoxime metabolic process

[Term]
id: GO:0018984
name: naphthalenesulfonate metabolic process
namespace: biological_process
alt_id: GO:0018932
def: "The chemical reactions and pathways involving naphthalenesulfonate, sulfonated derivatives of naphthalene." [GOC:ai]
subset: gosubset_prok
synonym: "naphthalenesulfonate metabolism" EXACT []
synonym: "naphthalenesulphonate metabolic process" EXACT []
synonym: "naphthalenesulphonate metabolism" EXACT []
xref: UM-BBD_pathwayID:nphs
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0018931 ! naphthalene metabolic process

[Term]
id: GO:0018985
name: pronuclear envelope synthesis
namespace: biological_process
def: "Synthesis and ordering of the envelope of pronuclei." [GOC:ems]
is_a: GO:0006998 ! nuclear envelope organization
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0018988
name: molting cycle, protein-based cuticle
namespace: biological_process
def: "The periodic shedding of part or all of a cuticle, which is then replaced by a new cuticle. A cuticle is the outer layer of an animal which acts to prevent water loss." [GOC:ems, GOC:mtg_sensu]
is_a: GO:0042303 ! molting cycle

[Term]
id: GO:0018989
name: apolysis
namespace: biological_process
def: "The first process of molting, characterized by the detachment of the old cuticle from the underlying epidermal cells." [GOC:jl]
xref: Wikipedia:Apolysis
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle

[Term]
id: GO:0018990
name: ecdysis, chitin-based cuticle
namespace: biological_process
def: "The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0042394 ! ecdysis, protein-based cuticle
relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle

[Term]
id: GO:0018991
name: oviposition
namespace: biological_process
def: "The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems]
synonym: "egg laying" BROAD []
xref: Wikipedia:Oviposition
is_a: GO:0033057 ! reproductive behavior in a multicellular organism

[Term]
id: GO:0018992
name: germ-line sex determination
namespace: biological_process
def: "The determination of sex and sexual phenotype in an organism's germ line." [GOC:ems]
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0018993
name: somatic sex determination
namespace: biological_process
def: "The determination of sex and sexual phenotypes in an organism's soma." [GOC:ems]
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0018995
name: host
namespace: cellular_component
def: "Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "host organism" EXACT []
xref: Wikipedia:Host_(biology)
is_a: GO:0044215 ! other organism

[Term]
id: GO:0018996
name: molting cycle, collagen and cuticulin-based cuticle
namespace: biological_process
def: "The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle. An example of this is found in the Nematode worm, Caenorhabditis elegans." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0018988 ! molting cycle, protein-based cuticle

[Term]
id: GO:0018997
name: electron transfer carrier
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because the parent terms cover its function.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0018998
name: metaxin
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a single gene product and not a complex.
is_obsolete: true
consider: GO:0005741

[Term]
id: GO:0019000
name: endonuclease G activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [PMID:12444964, PMID:12928502, PMID:12941691]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0004520
consider: GO:0004521

[Term]
id: GO:0019001
name: guanyl nucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: Reactome:6405 "guanyl nucleotide binding"
is_a: GO:0017076 ! purine nucleotide binding

[Term]
id: GO:0019002
name: GMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with GMP, guanosine monophosphate." [GOC:ai]
is_a: GO:0001883 ! purine nucleoside binding
is_a: GO:0032561 ! guanyl ribonucleotide binding

[Term]
id: GO:0019003
name: GDP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate." [GOC:ai]
is_a: GO:0001883 ! purine nucleoside binding
is_a: GO:0032561 ! guanyl ribonucleotide binding

[Term]
id: GO:0019005
name: SCF ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
synonym: "CDL1 complex" EXACT []
synonym: "CRL1 complex" EXACT []
synonym: "Cul1-RING ubiquitin ligase complex" EXACT []
synonym: "cullin-RING ligase 1" EXACT []
synonym: "SCF complex" EXACT []
synonym: "SCF complex substrate recognition subunit" NARROW []
synonym: "Skp1/Cul1/F-box protein complex" EXACT []
xref: Wikipedia:SCF_complex
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0019008
name: molybdopterin synthase complex
namespace: cellular_component
alt_id: GO:0019009
def: "A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772]
subset: gosubset_prok
synonym: "molybdopterin converting factor complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0019010
name: farnesoic acid O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine." [PMID:12135499]
synonym: "S-adenosyl-methionine:farnesoic acid O-methyltransferase activity" EXACT []
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0019011
name: DNA replication accessory factor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it does not represent a true molecular function.
is_obsolete: true
consider: GO:0006260

[Term]
id: GO:0019012
name: virion
namespace: cellular_component
def: "The complete fully infectious extracellular virus particle." [ISBN:0781718325]
subset: goslim_pir
synonym: "complete virus particle" EXACT []
xref: Wikipedia:Virus
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0019013
name: viral nucleocapsid
namespace: cellular_component
alt_id: GO:0019014
def: "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534]
synonym: "core" BROAD []
synonym: "nucleocapsid" EXACT []
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019028 ! viral capsid

[Term]
id: GO:0019015
name: viral genome
namespace: cellular_component
def: "The whole of the genetic information of a virus, contained as either DNA or RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0044423 ! virion part

[Term]
id: GO:0019016
name: non-segmented viral genome
namespace: cellular_component
def: "A viral genome that consists of one continuous nucleic acid molecule." [GOC:pk]
is_a: GO:0019015 ! viral genome

[Term]
id: GO:0019017
name: segmented viral genome
namespace: cellular_component
def: "A viral genome that is divided into two or more physically separate molecules of nucleic acid and packaged into a single virion." [ISBN:0121585336]
is_a: GO:0019015 ! viral genome

[Term]
id: GO:0019018
name: bipartite viral genome
namespace: cellular_component
def: "A segmented viral genome consisting of two sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336]
is_a: GO:0019017 ! segmented viral genome

[Term]
id: GO:0019019
name: tripartite viral genome
namespace: cellular_component
def: "A segmented viral genome consisting of three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336]
is_a: GO:0019017 ! segmented viral genome

[Term]
id: GO:0019020
name: multipartite viral genome
namespace: cellular_component
def: "A segmented viral genome consisting of more than three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336]
is_a: GO:0019017 ! segmented viral genome

[Term]
id: GO:0019021
name: DNA viral genome
namespace: cellular_component
def: "A viral genome composed of deoxyribonucleic acid." [ISBN:0121585336]
is_a: GO:0019015 ! viral genome

[Term]
id: GO:0019022
name: RNA viral genome
namespace: cellular_component
def: "A viral genome composed of ribonucleic acid. This results in genome replication and expression of genetic information being inextricably linked." [ISBN:0121585336]
is_a: GO:0019015 ! viral genome

[Term]
id: GO:0019023
name: dsRNA viral genome
namespace: cellular_component
def: "A viral genome composed of double stranded RNA." [ISBN:0121585336]
is_a: GO:0019022 ! RNA viral genome

[Term]
id: GO:0019024
name: ssRNA viral genome
namespace: cellular_component
def: "A viral genome composed of single stranded RNA of either positive or negative sense." [ISBN:0121585336]
is_a: GO:0019022 ! RNA viral genome

[Term]
id: GO:0019025
name: positive sense viral genome
namespace: cellular_component
def: "A single stranded RNA genome with the same nucleotide polarity as mRNA." [ISBN:0121585336]
is_a: GO:0019024 ! ssRNA viral genome

[Term]
id: GO:0019026
name: negative sense viral genome
namespace: cellular_component
def: "A single stranded RNA genome with the opposite nucleotide polarity as mRNA." [ISBN:0121585336]
is_a: GO:0019024 ! ssRNA viral genome

[Term]
id: GO:0019027
name: ambisense viral genome
namespace: cellular_component
def: "A RNA genome that contains coding regions that are either positive sense or negative sense on the same RNA molecule." [ISBN:0121585336]
is_a: GO:0019024 ! ssRNA viral genome

[Term]
id: GO:0019028
name: viral capsid
namespace: cellular_component
alt_id: GO:0046728
def: "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: Wikipedia:Capsid
is_a: GO:0044423 ! virion part

[Term]
id: GO:0019029
name: helical viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure." [ISBN:071673706X]
is_a: GO:0019028 ! viral capsid

[Term]
id: GO:0019030
name: icosahedral viral capsid
namespace: cellular_component
def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Tobacco satellite necrosis virus has such a capsid structure." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:071673706X]
synonym: "quasispherical viral capsid" EXACT []
is_a: GO:0019028 ! viral capsid

[Term]
id: GO:0019031
name: viral envelope
namespace: cellular_component
def: "The lipid bilayer and associated glycoproteins that surround many types of virus particle." [ISBN:0781718325]
synonym: "viral glycoprotein" RELATED []
synonym: "viral membrane" EXACT []
xref: Wikipedia:Viral_envelope
is_a: GO:0044423 ! virion part

[Term]
id: GO:0019032
name: viral glycoprotein
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a type of gene product and not a location or complex.
is_obsolete: true
consider: GO:0019031

[Term]
id: GO:0019033
name: viral tegument
namespace: cellular_component
def: "A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
xref: Wikipedia:Viral_tegument
is_a: GO:0044423 ! virion part

[Term]
id: GO:0019034
name: viral replication complex
namespace: cellular_component
def: "Specific locations and structures in the virus infected cell involved in replicating the viral genome." [ISBN:0781718325]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0019035
name: viral integration complex
namespace: cellular_component
def: "Virus-specific complex of protein required for integrating viral genomes into the host genome." [ISBN:0781718325]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0019036
name: viral transcriptional complex
namespace: cellular_component
def: "Specific locations and structures in the virus infected cell involved in transcribing the viral genome." [ISBN:0781718325]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0019037
name: viral assembly intermediate
namespace: cellular_component
def: "Specific locations and structures in the virus infected cell involved in assembling new virions." [ISBN:0781718325]
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0019038
name: provirus
namespace: cellular_component
def: "The name given to a viral genome after it has been integrated into the host genome; particularly applies to retroviruses and is a required part of the retroviral replication cycle." [ISBN:0121585336]
xref: Wikipedia:Provirus
is_a: GO:0019015 ! viral genome
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0019039
name: viral-cell fusion molecule activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0019064
consider: GO:0050839

[Term]
id: GO:0019040
name: viral host shutoff protein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
consider: GO:0004534
consider: GO:0019057

[Term]
id: GO:0019041
name: viral antireceptor activity
namespace: molecular_function
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0019042
name: latent virus infection
namespace: biological_process
def: "A viral process characterized by (a) the lack of efficient expression of all the viral genes that are transcribed during productive infection, and (b) the activation of a unique latent transcriptional progam." [ISBN:0781702534]
is_a: GO:0022415 ! viral reproductive process

[Term]
id: GO:0019043
name: establishment of viral latency
namespace: biological_process
def: "The process by which a virus reaches a latent state." [ISBN:0781702534]
synonym: "lysogenic commitment" EXACT []
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019042 ! latent virus infection

[Term]
id: GO:0019044
name: latent virus maintenance
namespace: biological_process
def: "Any process required for maintaining the latent form of the viral genome within a cell." [ISBN:0781718325]
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019042 ! latent virus infection

[Term]
id: GO:0019045
name: latent virus replication
namespace: biological_process
def: "Any process required for latent viral replication in a cell." [ISBN:0781702534]
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019042 ! latent virus infection

[Term]
id: GO:0019046
name: reactivation of latent virus
namespace: biological_process
def: "The reactivation of a virus from a latent to a lytic state." [ISBN:0781702534]
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019042 ! latent virus infection

[Term]
id: GO:0019047
name: provirus integration
namespace: biological_process
def: "The molecular events that lead to the integration of a viral genome into the host genome." [ISBN:0121585336]
synonym: "prophage integration" EXACT []
xref: Reactome:162592 "Integration of provirus"
xref: Reactome:175567 "Integration of viral DNA into host genomic DNA"
is_a: GO:0006310 ! DNA recombination
is_a: GO:0015074 ! DNA integration
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0030069 ! lysogeny

[Term]
id: GO:0019048
name: virus-host interaction
namespace: biological_process
def: "Interactions, directly with the host cell macromolecular machinery, to allow virus replication." [ISBN:0781718325]
synonym: "viral interaction with host" EXACT []
xref: Reactome:168253 "Host Interactions with Influenza Factors"
is_a: GO:0022415 ! viral reproductive process
is_a: GO:0051701 ! interaction with host

[Term]
id: GO:0019049
name: evasion of host defenses by virus
namespace: biological_process
def: "Any process, either active or passive, by which a virus avoids or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:1555811272]
synonym: "viral host defence evasion" EXACT []
synonym: "viral host defense evasion" EXACT []
is_a: GO:0019048 ! virus-host interaction
is_a: GO:0044415 ! evasion or tolerance of host defenses

[Term]
id: GO:0019050
name: suppression by virus of host apoptosis
namespace: biological_process
def: "Any viral process that results in the inhibition of apoptosis, facilitating prolonged cell survival during viral replication." [ISBN:0781718325]
synonym: "negative regulation by virus of host apoptosis" EXACT []
synonym: "negative regulation of apoptosis by virus" EXACT []
synonym: "suppression of apoptosis in host by virus" EXACT []
is_a: GO:0019054 ! modulation by virus of host cellular process
is_a: GO:0033668 ! negative regulation by symbiont of host apoptosis

[Term]
id: GO:0019051
name: induction by virus of host apoptosis
namespace: biological_process
def: "The set of viral processes that result in the induction of apoptosis of infected cells, facilitating release and spread of progeny virions." [ISBN:0781718325]
synonym: "activation by virus of host apoptosis" EXACT []
synonym: "activation by virus of host apoptotic programmed cell death" EXACT []
synonym: "activation of apoptosis in host by virus" EXACT []
synonym: "induction by virus of host apoptotic programmed cell death" EXACT []
synonym: "induction of apoptosis in host by virus" EXACT []
is_a: GO:0019054 ! modulation by virus of host cellular process
is_a: GO:0052030 ! induction by symbiont of host apoptosis
is_a: GO:0060139 ! positive regulation of apoptosis by virus

[Term]
id: GO:0019052
name: suppression by virus of host intracellular antiviral response
namespace: biological_process
def: "Any viral process that results in the inhibition of intracellular (innate immune response) antiviral mechanisms, thereby facilitating viral replication." [GOC:pk]
synonym: "negative regulation by virus of intracellular antiviral response" EXACT []
synonym: "negative regulation of host intracellular antiviral response by virus" EXACT []
synonym: "suppression of host intracellular antiviral response by virus" EXACT []
synonym: "viral inhibition of intracellular antiviral response" EXACT []
is_a: GO:0019049 ! evasion of host defenses by virus
is_a: GO:0050687 ! negative regulation of defense response to virus
is_a: GO:0050690 ! regulation of defense response to virus by virus

[Term]
id: GO:0019053
name: suppression by virus of host extracellular antiviral response
namespace: biological_process
def: "Any viral process that results in the inhibition of extracellular (adaptive immune response) antiviral mechanisms, thereby facilitating viral replication." [GOC:pk]
synonym: "inhibition of extracellular antiviral response" EXACT []
synonym: "negative regulation by virus of extracellular antiviral response" EXACT []
synonym: "negative regulation of host extracellular antiviral response by virus" EXACT []
synonym: "suppression of host extracellular antiviral response by virus" EXACT []
is_a: GO:0019049 ! evasion of host defenses by virus
is_a: GO:0050687 ! negative regulation of defense response to virus
is_a: GO:0050690 ! regulation of defense response to virus by virus

[Term]
id: GO:0019054
name: modulation by virus of host cellular process
namespace: biological_process
def: "The process in which a virus effects a change in the cellular pathways and activities of its host organism." [GOC:mah, GOC:pk]
synonym: "modification by virus of host cellular process" EXACT []
synonym: "modulation of cellular process in host by virus" RELATED []
synonym: "regulation by virus of host cellular process" EXACT []
synonym: "regulation of cellular process in host by virus" EXACT []
synonym: "regulation of host cellular process by virus" EXACT []
synonym: "viral host cell process manipulation" EXACT []
xref: Reactome:168276 "NS1 Mediated Effects on Host Pathways"
is_a: GO:0019048 ! virus-host interaction
is_a: GO:0044068 ! modulation by symbiont of host cellular process

[Term]
id: GO:0019055
name: modification by virus of host cell cycle regulation
namespace: biological_process
def: "Interactions, directly with the host cell macromolecular machinery, to allow a virus to modulate the rate of the host cell cycle to facilitate virus replication." [GOC:dph, ISBN:0781718325]
synonym: "viral perturbation of cell cycle regulation" EXACT []
is_a: GO:0019054 ! modulation by virus of host cellular process

[Term]
id: GO:0019056
name: modulation by virus of host transcription
namespace: biological_process
def: "The modulation by viral gene products of host RNA polymerase II facilitated transcription." [ISBN:0781718325]
synonym: "modification by virus of host transcription" EXACT []
synonym: "viral perturbation of host cell transcription" EXACT []
is_a: GO:0019054 ! modulation by virus of host cellular process
is_a: GO:0052026 ! modulation by symbiont of host transcription

[Term]
id: GO:0019057
name: modulation of host translation by virus
namespace: biological_process
def: "Any process by which a virus modulates the frequency, rate or extent of translation of host mRNA." [ISBN:0781718325]
synonym: "host cell protein synthesis shutoff" BROAD []
synonym: "host cell shutoff" BROAD []
synonym: "modification by virus of host cell mRNA translation" EXACT []
synonym: "regulation of host mRNA translation by virus" EXACT []
synonym: "regulation of host translation by virus" EXACT []
synonym: "regulation of translation in host by virus" EXACT []
synonym: "viral host shutoff protein" RELATED []
synonym: "viral perturbation of host cell mRNA translation" EXACT []
is_a: GO:0019054 ! modulation by virus of host cellular process
is_a: GO:0044073 ! modulation by symbiont of host translation

[Term]
id: GO:0019058
name: viral infectious cycle
namespace: biological_process
def: "A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272]
synonym: "lytic viral life cycle" NARROW []
xref: Reactome:168254 "Influenza Infection"
is_a: GO:0022415 ! viral reproductive process

[Term]
id: GO:0019059
name: initiation of viral infection
namespace: biological_process
def: "The set of processes involved in the start of virus infection of cells." [ISBN:0781702534]
xref: Reactome:162594 "Early Phase of HIV Life Cycle"
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019058 ! viral infectious cycle

[Term]
id: GO:0019060
name: intracellular transport of viral proteins in host cell
namespace: biological_process
def: "The directed movement of viral proteins within the host cell." [ISBN:0781702534]
synonym: "intracellular viral protein transport" EXACT []
xref: Reactome:168869 "Budding of vesicle with the HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum into the cytosol"
xref: Reactome:168871 "Fusion of vesicle containing the HA trimer, NA tetramer and M2 tetramer to the Golgi apparatus"
xref: Reactome:168874 "Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus"
xref: Reactome:168884 "Entry of HA into the endoplasmic reticulum"
is_a: GO:0022415 ! viral reproductive process
is_a: GO:0030581 ! symbiont intracellular protein transport in host
relationship: part_of GO:0046719 ! regulation of viral protein levels in host cell

[Term]
id: GO:0019061
name: uncoating of virus
namespace: biological_process
def: "A general term applied to the events that occur after penetration; refers to the 'uncoating' of the viral genome from the nucleocapsid core." [ISBN:0781702534]
synonym: "viral uncoating" EXACT []
xref: Reactome:162585 "Uncoating of the HIV Virion"
xref: Reactome:168299 "Ribonucleoprotein release from M1 proteins"
xref: Reactome:168313 "Virion-associated M2 protein mediated ion infusion"
xref: Reactome:168336 "Uncoating of the Influenza Virion"
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019059 ! initiation of viral infection

[Term]
id: GO:0019062
name: virion attachment to host cell surface receptor
namespace: biological_process
def: "Any process involved in the specific binding of a viral antireceptor to a cell surface receptor." [ISBN:0781702534]
synonym: "virion attachment" EXACT []
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0046718 ! entry of virus into host cell

[Term]
id: GO:0019063
name: virion penetration into host cell
namespace: biological_process
def: "Any process required for the introduction of virus particles into the cell." [ISBN:0781702534]
synonym: "virion penetration" EXACT []
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0046718 ! entry of virus into host cell

[Term]
id: GO:0019064
name: viral envelope fusion with host membrane
namespace: biological_process
def: "A form of viral penetration which involves the fusion of the virion envelope with the cellular membrane." [ISBN:0781702534]
synonym: "viral envelope fusion" BROAD []
synonym: "viral envelope fusion with host cell membrane" EXACT []
synonym: "viral envelope fusion with host plasma membrane" EXACT []
synonym: "viral-cell fusion molecule activity" RELATED []
xref: Reactome:164524 "Fusion of viral membrane with host cell membrane"
xref: Reactome:168288 "Fusion of the Influenza Virion to the Host Cell Endosome"
xref: Reactome:168306 "Concerted hemagglutinin pore formation"
xref: Reactome:168312 "Fusion of the influenza virion HA2 protein transmembrane domain to the host cell endosome membrane"
is_a: GO:0019063 ! virion penetration into host cell
is_a: GO:0061025 ! membrane fusion

[Term]
id: GO:0019065
name: receptor mediated endocytosis of virus by host
namespace: biological_process
def: "Endocytosis of the virus particle resulting in the accumulation of virus particles within the cell via cytoplasmic vesicles." [ISBN:0781702534]
synonym: "receptor mediated endocytosis by host of virus particle" EXACT []
synonym: "receptor mediated endocytosis of virus particle by host" EXACT []
synonym: "viral receptor mediated endocytosis" EXACT []
xref: Reactome:168275 "Entry of Influenza Virion into Host Cell via Endocytosis"
xref: Reactome:168285 "Clathrin-Mediated Pit Formation And Endocytosis Of The Influenza Virion"
is_a: GO:0006898 ! receptor-mediated endocytosis
relationship: part_of GO:0019063 ! virion penetration into host cell

[Term]
id: GO:0019066
name: translocation of virus into host cell
namespace: biological_process
def: "The translocation of an entire virus particle across the host cell plasma membrane." [ISBN:0781702534]
synonym: "viral translocation" EXACT []
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019063 ! virion penetration into host cell

[Term]
id: GO:0019067
name: viral assembly, maturation, egress, and release
namespace: biological_process
def: "Any process involved in the assembly, maturation, egress, and release of progeny virions." [ISBN:1555811272]
xref: Reactome:168268 "Virus Assembly and Release"
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019058 ! viral infectious cycle

[Term]
id: GO:0019068
name: virion assembly
namespace: biological_process
def: "A late phase of viral replication during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed." [ISBN:0121585336]
synonym: "viral assembly" EXACT []
synonym: "viral particle assembly" EXACT []
synonym: "virus assembly" EXACT [GOC:dph, GOC:tb]
synonym: "virus particle assembly" EXACT []
xref: Reactome:168302 "Budding"
xref: Reactome:168316 "Assembly of Viral Components at the Budding Site"
xref: Reactome:168862 "Association of HA into rafts"
xref: Reactome:168882 "Association of NP into rafts"
xref: Reactome:168894 "Accumulation of M1 at the inner leaflet of the lipid bilayer"
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019067 ! viral assembly, maturation, egress, and release

[Term]
id: GO:0019069
name: viral capsid assembly
namespace: biological_process
def: "The assembly of a virus capsid from its protein subunits." [ISBN:0781702534]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019068 ! virion assembly

[Term]
id: GO:0019070
name: viral genome maturation
namespace: biological_process
def: "Any viral process that occurs on newly synthesized viral genomes." [GOC:pk]
xref: Reactome:168330 "Viral RNP Complexes in the Host Cell Nucleus"
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019068 ! virion assembly

[Term]
id: GO:0019071
name: viral DNA cleavage
namespace: biological_process
def: "The cleavage of viral DNA into singular functional units." [ISBN:0121585336]
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019070 ! viral genome maturation

[Term]
id: GO:0019072
name: viral genome packaging
namespace: biological_process
def: "The encapsulation of the viral genome within the capsid." [ISBN:0121585336]
xref: Reactome:168303 "Packaging of Eight RNA Segments"
xref: Reactome:168895 "RNP association"
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019068 ! virion assembly

[Term]
id: GO:0019073
name: viral DNA genome packaging
namespace: biological_process
def: "The packing of viral DNA into a capsid." [ISBN:0781702534]
is_a: GO:0006323 ! DNA packaging
is_a: GO:0019072 ! viral genome packaging

[Term]
id: GO:0019074
name: viral RNA genome packaging
namespace: biological_process
def: "The packaging of viral RNA into a nucleocapsid." [ISBN:0781718325]
is_a: GO:0019072 ! viral genome packaging

[Term]
id: GO:0019075
name: virus maturation
namespace: biological_process
def: "The assembly of the component viral parts into an infectious virion." [ISBN:0781718325]
synonym: "viral maturation" EXACT []
synonym: "viral particle maturation" EXACT []
synonym: "virus particle maturation" RELATED []
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019067 ! viral assembly, maturation, egress, and release

[Term]
id: GO:0019076
name: release of virus from host
namespace: biological_process
def: "The process by which a virus becomes free of a host cell either by the lysis of the host cell or by a non-lytic mechanism." [ISBN:0781702534]
synonym: "viral release" EXACT []
xref: Reactome:168298 "Release"
xref: Reactome:168870 "Neuraminidase enzymatic release from sialic acid"
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019067 ! viral assembly, maturation, egress, and release

[Term]
id: GO:0019077
name: lytic viral release
namespace: biological_process
def: "A viral infection and replication that leads to the destruction (lysis) of the infected cell with the release of virions." [GOC:pk]
synonym: "lytic viral life cycle" NARROW []
is_a: GO:0019076 ! release of virus from host

[Term]
id: GO:0019078
name: lytic viral budding
namespace: biological_process
def: "A form of viral release in which the viral particles bud out through cellular membranes, resulting in cell lysis. It is also a form of viral envelopment." [ISBN:0781702534]
is_a: GO:0019077 ! lytic viral release

[Term]
id: GO:0019079
name: viral genome replication
namespace: biological_process
def: "Any process involved directly in viral genome replication, including viral nucleotide metabolism." [ISBN:0781702534]
synonym: "sigma virus replication" NARROW []
synonym: "viral replication" BROAD []
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019058 ! viral infectious cycle

[Term]
id: GO:0019080
name: viral genome expression
namespace: biological_process
def: "The achievement of highly specific, quantitative, temporal and spatial control of virus gene expression within the limited genetic resources of the viral genome." [ISBN:0121585336]
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019058 ! viral infectious cycle

[Term]
id: GO:0019081
name: viral protein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of viral proteins." [ISBN:0781702534]
synonym: "viral protein anabolism" EXACT []
synonym: "viral protein biosynthesis" EXACT []
synonym: "viral protein formation" EXACT []
synonym: "viral protein synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
relationship: part_of GO:0019080 ! viral genome expression

[Term]
id: GO:0019082
name: viral protein processing
namespace: biological_process
def: "The posttranslational processing of viral proteins." [ISBN:0781702534]
xref: Reactome:168858 "Palmitoylation of cysteine residues on HA in the cis-Golgi network"
xref: Reactome:168875 "Trimerization of HA"
is_a: GO:0016485 ! protein processing
relationship: part_of GO:0019080 ! viral genome expression

[Term]
id: GO:0019083
name: viral transcription
namespace: biological_process
def: "The mechanisms involved in viral gene transcription, especially referring to those with temporal properties unique to viral transcription." [ISBN:0781702534]
xref: Reactome:167172 "Transcription of the HIV genome"
xref: Reactome:168273 "Influenza Viral RNA Transcription and Replication"
xref: Reactome:168280 "Priming and Initiation of Transcription"
xref: Reactome:168293 "The 3' end of vRNA binds to PB1"
xref: Reactome:168301 "Polyadenylation and Termination"
xref: Reactome:168323 "A host cell mRNA binds to PB2"
xref: Reactome:168325 "Viral Messenger RNA Synthesis"
xref: Reactome:168326 "Assembly of an Active Transcription Complex"
xref: Reactome:168334 "Elongation of viral mRNA"
is_a: GO:0006350 ! transcription
relationship: part_of GO:0019080 ! viral genome expression

[Term]
id: GO:0019084
name: (delayed) early viral mRNA transcription
namespace: biological_process
def: "The second round of viral gene transcription; most genes transcribed in this round are necessary for genome replication." [ISBN:0781702534]
synonym: "beta protein" RELATED []
is_a: GO:0009299 ! mRNA transcription
is_a: GO:0019083 ! viral transcription

[Term]
id: GO:0019085
name: immediate early viral mRNA transcription
namespace: biological_process
def: "The transcriptional period of the earliest expressed viral genes, mainly encoding transcriptional regulators." [ISBN:0781702534]
synonym: "alpha protein" BROAD []
is_a: GO:0009299 ! mRNA transcription
is_a: GO:0019083 ! viral transcription

[Term]
id: GO:0019086
name: late viral mRNA transcription
namespace: biological_process
def: "The last group of viral genes to be transcribed during the viral life cycle; genes consist mainly of those encoding structural proteins." [ISBN:0781702534]
synonym: "gamma protein" RELATED []
is_a: GO:0009299 ! mRNA transcription
is_a: GO:0019083 ! viral transcription

[Term]
id: GO:0019087
name: transformation of host cell by virus
namespace: biological_process
def: "Any virus-induced change in the morphological, biochemical, or growth parameters of a cell." [ISBN:0781702534]
synonym: "viral transformation" EXACT []
synonym: "viral transformation of host cell" EXACT []
xref: Wikipedia:Viral_transformation
is_a: GO:0019048 ! virus-host interaction
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology

[Term]
id: GO:0019088
name: immortalization of host cell by virus
namespace: biological_process
def: "A virus-induced cellular transformation arising in immortalized cells, or cells capable of indefinite replication, due to their ability to produce their own telomerase." [ISBN:0781702534]
synonym: "viral immortalization" EXACT []
is_a: GO:0019087 ! transformation of host cell by virus
is_a: GO:0020021 ! immortalization of host cell

[Term]
id: GO:0019089
name: transmission of virus
namespace: biological_process
def: "The transfer of virions in order to create new infection." [ISBN:0781702534]
synonym: "viral transmission" EXACT []
is_a: GO:0022415 ! viral reproductive process
is_a: GO:0044007 ! dissemination or transmission of symbiont from host

[Term]
id: GO:0019090
name: mitochondrial rRNA export from mitochondrion
namespace: biological_process
def: "The directed movement of mitochondrial rRNA out of a mitochondrion." [GOC:ai]
synonym: "export of mitochondrial rRNA" BROAD []
synonym: "mitochondrial rRNA export" EXACT []
synonym: "mitochondrial rRNA export from mitochondria" EXACT []
synonym: "mitochondrial rRNA export out of mitochondrion" EXACT []
synonym: "mitochondrial rRNA transport from mitochondrion" EXACT []
synonym: "mitochondrial rRNA, mitochondrial export" EXACT []
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0019093 ! mitochondrial RNA localization
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:0019091
name: mitochondrial lrRNA export from mitochondrion
namespace: biological_process
def: "The directed movement of mitochondrial lrRNA out of a mitochondrion." [GOC:ai]
synonym: "export of mitochondrial lrRNA" BROAD []
synonym: "mitochondrial lrRNA export" EXACT []
synonym: "mitochondrial lrRNA export from mitochondria" EXACT []
synonym: "mitochondrial lrRNA export out of mitochondrion" EXACT []
synonym: "mitochondrial lrRNA transport from mitochondrion" EXACT []
synonym: "mitochondrial lrRNA, mitochondrial export" EXACT []
is_a: GO:0019090 ! mitochondrial rRNA export from mitochondrion

[Term]
id: GO:0019092
name: mitochondrial srRNA export from mitochondrion
namespace: biological_process
def: "The directed movement of mitochondrial srRNA out of a mitochondrion." [GOC:ai]
synonym: "export of mitochondrial srRNA" BROAD []
synonym: "mitochondrial srRNA export" EXACT []
synonym: "mitochondrial srRNA export from mitochondria" EXACT []
synonym: "mitochondrial srRNA export out of mitochondrion" EXACT []
synonym: "mitochondrial srRNA transport from mitochondrion" EXACT []
synonym: "mitochondrial srRNA, mitochondrial export" EXACT []
is_a: GO:0019090 ! mitochondrial rRNA export from mitochondrion

[Term]
id: GO:0019093
name: mitochondrial RNA localization
namespace: biological_process
def: "Any process by which mitochondrial RNA is transported to, or maintained in, a specific location." [GOC:ai]
synonym: "establishment and maintenance of mitochondrial RNA localization" EXACT []
synonym: "mtRNA localization" EXACT []
is_a: GO:0006403 ! RNA localization

[Term]
id: GO:0019094
name: pole plasm mRNA localization
namespace: biological_process
alt_id: GO:0048120
def: "Any process by which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai]
synonym: "establishment and maintenance of mRNA localization in pole plasm" EXACT []
synonym: "establishment and maintenance of pole plasm mRNA localization" EXACT []
synonym: "oocyte pole plasm mRNA localization" EXACT []
synonym: "pole granule RNA localization" BROAD []
is_a: GO:0007316 ! pole plasm RNA localization
is_a: GO:0008298 ! intracellular mRNA localization

[Term]
id: GO:0019095
name: pole plasm mitochondrial rRNA localization
namespace: biological_process
alt_id: GO:0048117
def: "Any process by which mitochondrial ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238]
synonym: "establishment and maintenance of mitochondrial rRNA localization in pole plasm" EXACT []
synonym: "oocyte pole plasm mitochondrial rRNA localization" EXACT []
is_a: GO:0007316 ! pole plasm RNA localization
is_a: GO:0019093 ! mitochondrial RNA localization

[Term]
id: GO:0019096
name: pole plasm mitochondrial lrRNA localization
namespace: biological_process
alt_id: GO:0048118
def: "Any process by which mitochondrial large ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238]
synonym: "establishment and maintenance of mitochondrial lrRNA localization in pole plasm" EXACT []
synonym: "oocyte pole plasm mitochondrial lrRNA localization" EXACT []
is_a: GO:0019095 ! pole plasm mitochondrial rRNA localization

[Term]
id: GO:0019097
name: pole plasm mitochondrial srRNA localization
namespace: biological_process
alt_id: GO:0048119
def: "Any process by which mitochondrial small ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238]
synonym: "establishment and maintenance of mitochondrial localization in pole plasm" EXACT []
synonym: "oocyte pole plasm mitochondrial srRNA localization" EXACT []
is_a: GO:0019095 ! pole plasm mitochondrial rRNA localization

[Term]
id: GO:0019098
name: reproductive behavior
namespace: biological_process
def: "The specific actions or reactions of an organism that are associated with reproduction." [GOC:jl]
synonym: "reproductive behaviour" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0022414 ! reproductive process

[Term]
id: GO:0019099
name: female germ-line sex determination
namespace: biological_process
alt_id: GO:0007544
def: "The determination of sex and sexual phenotype in a female organism's germ line." [GOC:mah]
synonym: "sex determination, female germ-line determination" EXACT []
is_a: GO:0007542 ! primary sex determination, germ-line
is_a: GO:0018992 ! germ-line sex determination
is_a: GO:0030237 ! female sex determination

[Term]
id: GO:0019100
name: male germ-line sex determination
namespace: biological_process
def: "The determination of sex and sexual phenotype in a male organism's germ line." [GOC:mah]
is_a: GO:0007542 ! primary sex determination, germ-line
is_a: GO:0018992 ! germ-line sex determination
is_a: GO:0030238 ! male sex determination

[Term]
id: GO:0019101
name: female somatic sex determination
namespace: biological_process
def: "The determination of sex and sexual phenotypes in a female organism's soma." [GOC:mah]
is_a: GO:0018993 ! somatic sex determination
is_a: GO:0030237 ! female sex determination

[Term]
id: GO:0019102
name: male somatic sex determination
namespace: biological_process
def: "The determination of sex and sexual phenotypes in a male organism's soma." [GOC:mah]
is_a: GO:0018993 ! somatic sex determination
is_a: GO:0030238 ! male sex determination

[Term]
id: GO:0019103
name: pyrimidine nucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate." [GOC:ai]
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0019104
name: DNA N-glycosylase activity
namespace: molecular_function
alt_id: GO:0008578
def: "Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296]
comment: Consider also annotating to the molecular function term 'damaged DNA binding ; GO:0003684'.
subset: gosubset_prok
synonym: "DNA glycosylase activity" EXACT []
synonym: "endonuclease VIII activity" RELATED []
xref: EC:3.2.2.-
xref: Reactome:7370 "DNA N-glycosylase activity"
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0019105
name: N-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0016409 ! palmitoyltransferase activity
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0019107
name: myristoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule." [GOC:ai]
xref: EC:2.3.1.-
xref: Reactome:2349 "myristoyltransferase activity"
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0019108
name: aryl-aldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+." [EC:1.2.1.29]
synonym: "aryl-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.29]
xref: EC:1.2.1.29
xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0228
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019111
name: phenanthrol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate." [EC:2.8.2.-]
synonym: "phenanthrol sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0019112
name: phenanthrol glycosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O." [GOC:ai]
xref: EC:2.4.1.-
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0019113
name: limonene monooxygenase activity
namespace: molecular_function
def: "Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene." [GOC:mah]
xref: EC:1.14.13.-
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0019114
name: catechol dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: catechol + O2 = a muconate." [GOC:mah, MetaCyc:CATECHOL-12-DIOXYGENASE-RXN, MetaCyc:CATECHOL-23-DIOXYGENASE-RXN]
subset: gosubset_prok
xref: EC:1.13.11.-
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0019115
name: benzaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+." [EC:1.2.1.28, EC:1.2.1.7]
subset: gosubset_prok
xref: EC:1.2.1.-
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019116
name: hydroxy-nicotine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2." [GOC:jl, http://umbbd.ahc.umn.edu/]
subset: gosubset_prok
xref: EC:1.5.3.-
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0019117
name: dihydroxyfluorene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid." [GOC:mah, UM-BBD_enzymeID:e0294, UM-BBD_enzymeID:e0295]
xref: EC:1.13.11.-
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0019118
name: phenanthrene-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene." [GOC:mah, UM-BBD_enzymeID:e0363, UM-BBD_enzymeID:e0364]
xref: EC:3.3.2.-
is_a: GO:0004301 ! epoxide hydrolase activity

[Term]
id: GO:0019119
name: phenanthrene-9,10-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene." [GOC:mah, UM-BBD_enzymeID:e0335, UM-BBD_enzymeID:e0367]
xref: EC:3.3.2.-
is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity

[Term]
id: GO:0019120
name: hydrolase activity, acting on acid halide bonds, in C-halide compounds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: EC:3.8.1
is_a: GO:0016824 ! hydrolase activity, acting on acid halide bonds

[Term]
id: GO:0019121
name: peptidoglycan-protein cross-linking via N6-mureinyl-L-lysine
namespace: biological_process
def: "The process of linking a protein to peptidoglycan via the epsilon amino group of lysine to the diaminopimelic acid of the peptidoglycan." [RESID:AA0218]
subset: gosubset_prok
xref: RESID:AA0218
is_a: GO:0018104 ! peptidoglycan-protein cross-linking
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0019122
name: peptidyl-D-alanine racemization
namespace: biological_process
def: "The formation of peptidyl-D-alanine, by either racemization or from peptidyl-L-serine." [RESID:AA0191]
comment: See also the biological process terms 'peptidyl-D-alanine racemization, direct ; GO:0019916' and 'peptidyl-D-alanine racemization via peptidyl-L-serine ; GO:0019917'.
subset: gosubset_prok
synonym: "alanine racemization" BROAD []
xref: RESID:AA0191
is_a: GO:0018085 ! peptidyl-L-amino acid racemization
is_a: GO:0018194 ! peptidyl-alanine modification

[Term]
id: GO:0019123
name: peptidyl-methionine racemization
namespace: biological_process
alt_id: GO:0018087
alt_id: GO:0018369
def: "The racemization of peptidyl-methionine." [RESID:AA0193]
subset: gosubset_prok
xref: RESID:AA0193
is_a: GO:0018085 ! peptidyl-L-amino acid racemization

[Term]
id: GO:0019124
name: peptidyl-isoleucine racemization
namespace: biological_process
alt_id: GO:0018088
alt_id: GO:0018370
def: "The racemization of peptidyl-isoleucine." [RESID:AA0192]
subset: gosubset_prok
xref: RESID:AA0192
is_a: GO:0018085 ! peptidyl-L-amino acid racemization

[Term]
id: GO:0019125
name: peptidyl-phenylalanine racemization
namespace: biological_process
alt_id: GO:0018089
alt_id: GO:0018371
def: "The racemization of peptidyl-phenylalanine." [RESID:AA0194]
subset: gosubset_prok
xref: RESID:AA0194
is_a: GO:0018085 ! peptidyl-L-amino acid racemization

[Term]
id: GO:0019126
name: peptidyl-serine racemization
namespace: biological_process
alt_id: GO:0018090
alt_id: GO:0018372
def: "The racemization of peptidyl-serine." [RESID:AA0195]
subset: gosubset_prok
xref: RESID:AA0195
is_a: GO:0018085 ! peptidyl-L-amino acid racemization

[Term]
id: GO:0019128
name: peptidyl-tryptophan racemization
namespace: biological_process
alt_id: GO:0018092
alt_id: GO:0018374
def: "The racemization of peptidyl-tryptophan." [RESID:AA0198]
subset: gosubset_prok
xref: RESID:AA0198
is_a: GO:0018085 ! peptidyl-L-amino acid racemization

[Term]
id: GO:0019129
name: peptidyl-leucine racemization
namespace: biological_process
alt_id: GO:0018093
alt_id: GO:0018375
def: "The racemization of peptidyl-leucine." [RESID:AA0197]
subset: gosubset_prok
xref: RESID:AA0197
is_a: GO:0018085 ! peptidyl-L-amino acid racemization

[Term]
id: GO:0019131
name: tripeptidyl-peptidase I activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH." [EC:3.4.14.9]
comment: This term was made obsolete because it represents a gene product.
synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.9]
synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.9]
xref: EC:3.4.14.9
xref: MetaCyc:3.4.14.9-RXN
is_obsolete: true
replaced_by: GO:0008240

[Term]
id: GO:0019132
name: C-terminal processing peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala." [EC:3.4.21.102]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "CtpA gene product (Synechocystis sp.)" RELATED [EC:3.4.21.102]
synonym: "photosystem II D1 protein processing peptidase" NARROW [EC:3.4.21.102]
synonym: "protease Re" RELATED [EC:3.4.21.102]
synonym: "tail-specific protease activity" EXACT [EC:3.4.21.102]
synonym: "Tsp protease" NARROW [EC:3.4.21.102]
xref: EC:3.4.21.102
xref: MetaCyc:3.4.21.102-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0019133
name: choline monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O." [EC:1.14.15.7]
subset: gosubset_prok
synonym: "choline,reduced-ferredoxin:oxygen oxidoreductase activity" EXACT [EC:1.14.15.7]
xref: EC:1.14.15.7
xref: MetaCyc:RXN1F-357
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0019134
name: glucosamine-1-phosphate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + D-glucosamine 1-phosphate = CoA + N-acetyl-D-glucosamine 1-phosphate." [EC:2.3.1.157]
subset: gosubset_prok
synonym: "acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.157]
synonym: "acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.157]
xref: EC:2.3.1.157
xref: MetaCyc:2.3.1.157-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0019135
name: deoxyhypusine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O." [EC:1.14.99.29]
synonym: "deoxyhypusine dioxygenase activity" EXACT [EC:1.14.99.29]
synonym: "deoxyhypusine hydroxylase activity" EXACT []
synonym: "deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.99.29]
synonym: "DOHH activity" EXACT [EC:1.14.99.29]
xref: EC:1.14.99.29
xref: MetaCyc:DEOXYHYPUSINE-MONOOXYGENASE-RXN
xref: Reactome:7455 "deoxyhypusine monooxygenase activity"
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0019136
name: deoxynucleoside kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145]
subset: gosubset_prok
synonym: "ATP:deoxynucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.145]
synonym: "D. melanogaster deoxynucleoside kinase activity" EXACT [EC:2.7.1.145]
synonym: "Dm-dNK" RELATED [EC:2.7.1.145]
synonym: "ms-dNK" RELATED [EC:2.7.1.145]
synonym: "Ms-dNK activity" RELATED [EC:2.7.1.145]
synonym: "multifunctional deoxynucleoside kinase activity" RELATED [EC:2.7.1.145]
synonym: "multispecific deoxynucleoside kinase activity" RELATED [EC:2.7.1.145]
synonym: "multisubstrate deoxyribonucleoside kinase activity" RELATED [EC:2.7.1.145]
xref: EC:2.7.1.145
xref: MetaCyc:2.7.1.145-RXN
is_a: GO:0019206 ! nucleoside kinase activity

[Term]
id: GO:0019137
name: thioglucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar." [EC:3.2.1.147]
synonym: "myrosinase activity" EXACT []
synonym: "sinigrase activity" EXACT []
synonym: "sinigrinase activity" EXACT []
synonym: "thioglucoside glucohydrolase activity" EXACT []
xref: EC:3.2.1.147
xref: MetaCyc:RXN-9946
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0019139
name: cytokinin dehydrogenase activity
namespace: molecular_function
alt_id: GO:0046420
def: "Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor." [EC:1.5.99.12]
synonym: "6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.12]
synonym: "cytokinin oxidase activity" RELATED []
synonym: "N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.12]
synonym: "N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.12]
xref: EC:1.5.99.12
xref: MetaCyc:1.5.99.12-RXN
xref: MetaCyc:PWY-2841
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0019140
name: inositol 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate." [EC:2.7.1.64]
synonym: "ATP:myo-inositol 1-phosphotransferase activity" EXACT [EC:2.7.1.64]
synonym: "inositol 1-kinase activity" RELATED [EC:2.7.1.64]
synonym: "inositol-1-kinase (phosphorylating)" EXACT [EC:2.7.1.64]
synonym: "myo-inositol 1-kinase activity" RELATED [EC:2.7.1.64]
synonym: "myo-inositol 3-kinase activity" EXACT []
synonym: "myoinositol kinase activity" BROAD [EC:2.7.1.64]
xref: EC:2.7.1.64
xref: MetaCyc:MYO-INOSITOL-1-KINASE-RXN
is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0019141
name: 2-dehydropantolactone reductase (B-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.214]
synonym: "(R)-pantolactone:NADP+ oxidoreductase (B-specific)" EXACT [EC:1.1.1.214]
synonym: "2-dehydropantoyl-lactone reductase (B-specific) activity" EXACT []
synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214]
synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.214]
synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214]
xref: EC:1.1.1.214
xref: MetaCyc:DEHYDROPANTLACRED-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019142
name: 2-hydroxyglutarate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: propanoyl-CoA + H2O + glyoxylate = 2-hydroxyglutarate + CoA." [EC:2.3.3.11]
comment: Note that this function was formerly EC:4.1.3.9.
synonym: "2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating) activity" EXACT [EC:2.3.3.11]
synonym: "2-hydroxyglutaratic synthetase activity" EXACT [EC:2.3.3.11]
synonym: "2-hydroxyglutaric synthetase activity" EXACT [EC:2.3.3.11]
synonym: "alpha-hydroxyglutarate synthase activity" EXACT [EC:2.3.3.11]
synonym: "hydroxyglutarate synthase activity" EXACT [EC:2.3.3.11]
synonym: "propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)" EXACT [EC:2.3.3.11]
xref: EC:2.3.3.11
xref: MetaCyc:HYDGLUTSYN-RXN
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0019143
name: 3-deoxy-manno-octulosonate-8-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-deoxy-D-manno-octulosonate 8-phosphate + H2O = 3-deoxy-D-manno-octulosonate + phosphate." [EC:3.1.3.45]
subset: gosubset_prok
synonym: "3-deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase activity" EXACT [EC:3.1.3.45]
xref: EC:3.1.3.45
xref: MetaCyc:KDO-8PPHOSPHAT-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0019144
name: ADP-sugar diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate." [EC:3.6.1.21]
subset: gosubset_prok
synonym: "adenosine diphosphosugar pyrophosphatase activity" EXACT [EC:3.6.1.21]
synonym: "ADP-sugar pyrophosphatase activity" EXACT [EC:3.6.1.21]
synonym: "ADP-sugar sugarphosphohydrolase activity" EXACT [EC:3.6.1.21]
synonym: "ADPsugar pyrophosphatase activity" EXACT [EC:3.6.1.21]
synonym: "nucleoside diphosphate-sugar hydrolase activity" BROAD [GOC:vw]
xref: EC:3.6.1.21
xref: MetaCyc:ADPSUGPPHOSPHAT-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0019145
name: aminobutyraldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+." [EC:1.2.1.19]
subset: gosubset_prok
synonym: "4-aminobutanal dehydrogenase activity" EXACT [EC:1.2.1.19]
synonym: "4-aminobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.19]
synonym: "4-aminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.19]
synonym: "ABAL dehydrogenase activity" EXACT [EC:1.2.1.19]
synonym: "gamma-aminobutyraldehyde dehydroganase activity" EXACT [EC:1.2.1.19]
xref: EC:1.2.1.19
xref: MetaCyc:AMINOBUTDEHYDROG-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019146
name: arabinose-5-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate." [EC:5.3.1.13]
subset: gosubset_prok
synonym: "arabinose phosphate isomerase activity" EXACT [EC:5.3.1.13]
synonym: "D-arabinose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.13]
synonym: "D-arabinose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.13]
synonym: "phosphoarabinoisomerase activity" EXACT [EC:5.3.1.13]
xref: EC:5.3.1.13
xref: MetaCyc:DARAB5PISOM-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0019147
name: (R)-aminopropanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD+ = aminoacetone + NADH + H+." [EC:1.1.1.75]
synonym: "(R)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.75]
synonym: "1-aminopropan-2-ol-dehydrogenase activity" EXACT [EC:1.1.1.75]
synonym: "1-aminopropan-2-ol-NAD+ dehydrogenase activity" EXACT [EC:1.1.1.75]
synonym: "DL-1-aminopropan-2-ol: NAD+ dehydrogenase activity" EXACT [EC:1.1.1.75]
synonym: "L(+)-1-aminopropan-2-ol-NAD/NADP oxidoreductase activity" EXACT [EC:1.1.1.75]
synonym: "L(+)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.75]
synonym: "L-aminopropanol dehydrogenase activity" EXACT []
xref: EC:1.1.1.75
xref: MetaCyc:AMINOPROPDEHYDROG-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019148
name: D-cysteine desulfhydrase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate." [EC:4.4.1.15]
subset: gosubset_prok
synonym: "D-cysteine lyase activity" EXACT [EC:4.4.1.15]
synonym: "D-cysteine sulfide-lyase (deaminating)" EXACT [EC:4.4.1.15]
synonym: "D-cysteine sulfide-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.15]
xref: EC:4.4.1.15
xref: MetaCyc:DCYSDESULF-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0019149
name: 3-chloro-D-alanine dehydrochlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3." [EC:4.5.1.2]
synonym: "3-chloro-D-alanine chloride-lyase (deaminating)" EXACT [EC:4.5.1.2]
synonym: "3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.5.1.2]
synonym: "beta-chloro-D-alanine dehydrochlorinase activity" EXACT [EC:4.5.1.2]
xref: EC:4.5.1.2
xref: MetaCyc:3-CHLORO-D-ALANINE-DEHYDROCHLORINASE-RXN
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0019150
name: D-ribulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate." [EC:2.7.1.47]
subset: gosubset_prok
synonym: "ATP:D-ribulose 5-phosphotransferase activity" EXACT [EC:2.7.1.47]
synonym: "D-ribulokinase (phosphorylating)" EXACT [EC:2.7.1.47]
xref: EC:2.7.1.47
xref: MetaCyc:D-RIBULOKIN-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0019151
name: galactose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+." [EC:1.1.1.48]
subset: gosubset_prok
synonym: "beta-galactose dehydrogenase activity" EXACT [EC:1.1.1.48]
synonym: "D-galactose 1-dehydrogenase activity" EXACT []
synonym: "D-galactose dehydrogenase activity" EXACT [EC:1.1.1.48]
synonym: "D-galactose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.48]
synonym: "NAD-dependent D-galactose dehydrogenase activity" EXACT [EC:1.1.1.48]
xref: EC:1.1.1.48
xref: MetaCyc:GALACTODEHYDROG-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019152
name: acetoin dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+." [EC:1.1.1.5]
subset: gosubset_prok
synonym: "diacetyl reductase activity" EXACT [EC:1.1.1.5]
xref: EC:1.1.1.5
xref: MetaCyc:ACETOINDEHYDROG-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019153
name: protein-disulfide reductase (glutathione) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol." [EC:1.8.4.2]
subset: gosubset_prok
synonym: "glutaredoxin reductase" RELATED []
synonym: "glutathione--insulin transhydrogenase activity" EXACT [EC:1.8.4.2]
synonym: "glutathione-insulin transhydrogenase activity" EXACT []
synonym: "glutathione-protein disulfide oxidoreductase activity" EXACT [EC:1.8.4.2]
synonym: "glutathione:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.4.2]
synonym: "GSH-insulin transhydrogenase activity" EXACT [EC:1.8.4.2]
synonym: "insulin reductase activity" EXACT [EC:1.8.4.2]
synonym: "protein disulfide reductase (glutathione)" EXACT [EC:1.8.4.2]
synonym: "protein disulfide transhydrogenase activity" EXACT [EC:1.8.4.2]
synonym: "protein-disulfide interchange enzyme" RELATED [EC:1.8.4.2]
synonym: "protein-disulfide isomerase/oxidoreductase activity" EXACT [EC:1.8.4.2]
synonym: "protein-disulphide reductase (glutathione) activity" EXACT []
synonym: "reductase, protein disulfide (glutathione)" EXACT [EC:1.8.4.2]
synonym: "thiol-protein disulphide oxidoreductase activity" EXACT [EC:1.8.4.2]
synonym: "thiol:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.4.2]
xref: EC:1.8.4.2
xref: MetaCyc:PRODISULFREDUCT-RXN
is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0019154
name: glycolate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycolate + acceptor = glyoxylate + reduced acceptor." [EC:1.1.99.14]
synonym: "glycolate oxidoreductase activity" EXACT [EC:1.1.99.14]
synonym: "glycolate:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.14]
synonym: "glycolate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.14]
synonym: "glycolic acid dehydrogenase activity" EXACT [EC:1.1.99.14]
xref: EC:1.1.99.14
xref: MetaCyc:GLYCOLATEDEHYDRO-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0019155
name: 3-(imidazol-5-yl)lactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+." [EC:1.1.1.111]
synonym: "(S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.111]
synonym: "imidazol-5-yl lactate dehydrogenase activity" EXACT [EC:1.1.1.111]
xref: EC:1.1.1.111
xref: MetaCyc:IMILACTDEHYDROG-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019156
name: isoamylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins." [EC:3.2.1.68]
subset: gosubset_prok
synonym: "debranching enzyme activity" BROAD [EC:3.2.1.68]
synonym: "glycogen alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.68]
xref: EC:3.2.1.68
xref: MetaCyc:3.2.1.68-RXN
is_a: GO:0004133 ! glycogen debranching enzyme activity
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0019157
name: malate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + O2 = oxaloacetate + H2O2." [EC:1.1.3.3]
synonym: "(S)-malate:oxygen oxidoreductase activity" EXACT [EC:1.1.3.3]
synonym: "FAD-dependent malate oxidase activity" EXACT [EC:1.1.3.3]
synonym: "malic dehydrogenase II" RELATED [EC:1.1.3.3]
synonym: "malic oxidase activity" EXACT [EC:1.1.3.3]
xref: EC:1.1.3.3
xref: MetaCyc:MALOX-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0019158
name: mannokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate." [EC:2.7.1.7]
subset: gosubset_prok
synonym: "ATP:D-mannose 6-phosphotransferase activity" EXACT [EC:2.7.1.7]
synonym: "D-fructose (D-mannose) kinase activity" EXACT [EC:2.7.1.7]
synonym: "mannokinase (phosphorylating)" EXACT [EC:2.7.1.7]
xref: EC:2.7.1.7
xref: MetaCyc:MANNKIN-RXN
is_a: GO:0004396 ! hexokinase activity

[Term]
id: GO:0019159
name: nicotinamide-nucleotide amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3." [EC:3.5.1.42]
synonym: "nicotinamide mononucleotide amidohydrolase activity" EXACT [EC:3.5.1.42]
synonym: "nicotinamide mononucleotide deamidase activity" EXACT [EC:3.5.1.42]
synonym: "nicotinamide-D-ribonucleotide amidohydrolase activity" EXACT [EC:3.5.1.42]
synonym: "NMN amidohydrolase" NARROW []
synonym: "NMN deamidase activity" EXACT [EC:3.5.1.42]
xref: EC:3.5.1.42
xref: MetaCyc:NMNAMIDOHYDRO-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0019160
name: NMN nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotinamide D-ribonucleotide + H2O = nicotinamide + D-ribose 5-phosphate." [EC:3.2.2.14]
synonym: "nicotinamide mononucleotidase activity" EXACT [EC:3.2.2.14]
synonym: "nicotinamide mononucleotide nucleosidase activity" EXACT [EC:3.2.2.14]
synonym: "nicotinamide-nucleotide phosphoribohydrolase activity" EXACT [EC:3.2.2.14]
synonym: "NMN glycohydrolase activity" EXACT [EC:3.2.2.14]
synonym: "NMNase activity" EXACT [EC:3.2.2.14]
synonym: "NMNGhase activity" EXACT [EC:3.2.2.14]
xref: EC:3.2.2.14
xref: MetaCyc:NMNNUCLEOSID-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0019161
name: diamine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate." [EC:2.6.1.29]
synonym: "amine transaminase activity" EXACT [EC:2.6.1.29]
synonym: "amine-ketoacid transaminase activity" EXACT [EC:2.6.1.29]
synonym: "diamine aminotransferase activity" EXACT []
synonym: "diamine-ketoglutaric transaminase activity" EXACT [EC:2.6.1.29]
synonym: "diamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.29]
xref: EC:2.6.1.29
xref: MetaCyc:DIAMTRANSAM-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0019162
name: pyridoxamine-oxaloacetate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxamine + oxaloacetate = pyridoxal + L-aspartate." [EC:2.6.1.31]
synonym: "pyridoxamine--oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.31]
synonym: "pyridoxamine-oxaloacetate aminotransferase activity" EXACT []
synonym: "pyridoxamine:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.31]
xref: EC:2.6.1.31
xref: MetaCyc:PYROXALTRANSAM-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0019163
name: pyridoxamine-phosphate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate." [EC:2.6.1.54]
synonym: "pyridoxamine 5'-phosphate transaminase activity" EXACT [EC:2.6.1.54]
synonym: "pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.54]
synonym: "pyridoxamine phosphate aminotransferase activity" EXACT [EC:2.6.1.54]
synonym: "pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming)" EXACT [EC:2.6.1.54]
synonym: "pyridoxamine-phosphate aminotransferase activity" EXACT []
xref: EC:2.6.1.54
xref: MetaCyc:PYRDAMPTRANS-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0019164
name: pyruvate synthase activity
namespace: molecular_function
alt_id: GO:0018696
def: "Catalysis of the reaction: pyruvate + CoA + oxidized ferredoxin = acetyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.1]
subset: gosubset_prok
synonym: "pyruvate oxidoreductase activity" EXACT [EC:1.2.7.1]
synonym: "pyruvate synthetase activity" EXACT [EC:1.2.7.1]
synonym: "pyruvate-ferredoxin reductase activity" EXACT []
synonym: "pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.7.1]
synonym: "pyruvate:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.1]
synonym: "pyruvic-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.1]
xref: EC:1.2.7.1
xref: MetaCyc:PYRUFLAVREDUCT-RXN
xref: UM-BBD_enzymeID:e0417
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0019165
name: thiamin kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thiamin = ADP + thiamin phosphate." [EC:2.7.1.89]
synonym: "ATP:thiamin phosphotransferase activity" EXACT [EC:2.7.1.89]
synonym: "ATP:thiamine phosphotransferase activity" EXACT [EC:2.7.1.89]
synonym: "thiamin kinase (phosphorylating)" EXACT [EC:2.7.1.89]
synonym: "thiamin phosphokinase activity" EXACT [EC:2.7.1.89]
synonym: "thiamine kinase activity" EXACT []
xref: EC:2.7.1.89
xref: MetaCyc:THIKIN-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0019166
name: trans-2-enoyl-CoA reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.38]
synonym: "acyl-CoA:NADP+ trans-2-oxidoreductase activity" EXACT [EC:1.3.1.38]
synonym: "NADPH-dependent trans-2-enoyl-CoA reductase activity" EXACT [EC:1.3.1.38]
synonym: "reductase, trans-enoyl coenzyme A" EXACT [EC:1.3.1.38]
xref: EC:1.3.1.38
xref: MetaCyc:TRANSENOYLCOARED-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019168
name: 2-octaprenylphenol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol." [MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN]
xref: MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0019170
name: methylglyoxal reductase (NADH-dependent) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+." [EC:1.1.1.78]
synonym: "(R)-lactaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.78]
synonym: "D-lactaldehyde dehydrogenase activity" EXACT []
synonym: "methylglyoxal reductase activity" EXACT []
xref: EC:1.1.1.78
xref: MetaCyc:D-LACTALDEHYDE-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0019171
name: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: CH3-CHOH-CH2-[CH2]n-CO-[acyl-carrier protein] = H2O + CH3-CH-CH-[CH2]n-CO-[acyl-carrier protein]." [EC:4.2.1.-, GOC:ai]
subset: gosubset_prok
synonym: "3-hydroxyacyl-[acyl-carrier protein] dehydratase activity" EXACT []
synonym: "3-hydroxyacyl-ACP dehydratase activity" EXACT []
xref: EC:4.2.1.-
xref: MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN
xref: Reactome:76135 "3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0019172
name: glyoxalase III activity
namespace: molecular_function
def: "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." [MetaCyc:GLYOXIII-RXN]
comment: Note that this term was reinstated from obsolete.
xref: MetaCyc:GLYOXIII-RXN
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0019174
name: tetrahydrothiophene 1-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor." [MetaCyc:THTOREDUCT-RXN]
xref: MetaCyc:THTOREDUCT-RXN
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0019175
name: alpha-ribazole-5'-P phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-ribazole-5'-phosphate = alpha-ribazole + phosphate." [MetaCyc:RIBAZOLEPHOSPHAT-RXN]
subset: gosubset_prok
xref: EC:3.1.3.-
xref: MetaCyc:RIBAZOLEPHOSPHAT-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0019176
name: dihydroneopterin monophosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate." [MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN]
synonym: "dihydroneopterin monophosphate dephosphorylase activity" EXACT []
xref: EC:3.6.1.-
xref: MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0019177
name: dihydroneopterin triphosphate pyrophosphohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate." [MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN]
xref: EC:3.6.1.-
xref: MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0019178
name: NADP phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate." [MetaCyc:NADPPHOSPHAT-RXN]
xref: EC:3.1.3.-
xref: MetaCyc:NADPPHOSPHAT-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0019179
name: dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate." [EC:2.6.1.33]
synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase activity" EXACT []
synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.33]
synonym: "TDP-4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33]
synonym: "TDP-4-oxo-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33]
synonym: "thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase activity" EXACT [EC:2.6.1.33]
synonym: "thymidine diphospho-4-amino-6-deoxyglucose aminotransferase activity" EXACT [EC:2.6.1.33]
synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33]
synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase activity" EXACT [EC:2.6.1.33]
xref: EC:2.6.1.33
xref: MetaCyc:2.6.1.33-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0019180
name: dTDP-4-amino-4,6-dideoxygalactose transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-galactose + L-glutamate." [EC:2.6.1.59]
synonym: "dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.59]
synonym: "dTDP-4-amino-4,6-dideoxygalactose aminotransferase activity" EXACT [EC:2.6.1.59]
synonym: "dTDP-fucosamine aminotransferase activity" EXACT []
synonym: "thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.59]
synonym: "thymidine diphosphoaminodideoxygalactose aminotransferase activity" EXACT [EC:2.6.1.59]
xref: EC:2.6.1.59
xref: MetaCyc:2.6.1.59-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0019181
name: halohydrin hydrogen-halide-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: a halohydrin = an epoxide + a hydrogen halide." [PMID:8017917]
xref: EC:4.5.1.-
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0019182
name: histamine-gated chloride channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0015276 ! ligand-gated ion channel activity

[Term]
id: GO:0019183
name: histamine-gated chloride channel complex
namespace: cellular_component
def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts." [GOC:mah]
is_a: GO:0034707 ! chloride channel complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0019184
name: nonribosomal peptide biosynthetic process
namespace: biological_process
def: "The biosynthetic process whereby peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "non-ribosomal peptide biosynthesis" EXACT []
synonym: "non-ribosomal peptide biosynthetic process" EXACT []
synonym: "non-ribosomal peptide formation" EXACT []
synonym: "non-ribosomal peptide synthesis" EXACT []
synonym: "nonribosomal peptide anabolism" EXACT []
synonym: "nonribosomal peptide biosynthesis" EXACT []
synonym: "nonribosomal peptide formation" EXACT []
synonym: "nonribosomal peptide synthesis" EXACT []
synonym: "nonribosomal peptide synthetase" RELATED []
is_a: GO:0043043 ! peptide biosynthetic process

[Term]
id: GO:0019185
name: snRNA-activating protein complex
namespace: cellular_component
def: "A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters." [PMID:7715707, PMID:9003788]
synonym: "SNAPc" EXACT []
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0019186
name: acyl-CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group from acyl-CoA to a nitrogen atom on an acceptor molecule." [GOC:mah]
xref: EC:2.3.1.-
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0019187
name: beta-1,4-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming a beta-1,4-linkage." [GOC:mcc, PMID:8166646]
xref: EC:2.4.1.-
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0019191
name: cellobiose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0019190
def: "Catalysis of the transfer of cellobiose from one side of the membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
synonym: "cellobiose permease activity" EXACT []
is_a: GO:0015154 ! disaccharide transmembrane transporter activity

[Term]
id: GO:0019194
name: sorbose transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0019193
def: "Catalysis of the transfer of sorbose from one side of the membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "sorbose porter activity" EXACT []
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0019196
name: galactosamine transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0019195
def: "Catalysis of the transfer of galactosamine from one side of the membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
synonym: "galactosamine porter activity" EXACT []
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0019197
name: phosphoenolpyruvate-dependent sugar phosphotransferase complex
namespace: cellular_component
def: "Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system)." [GOC:ma]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0019198
name: transmembrane receptor protein phosphatase activity
namespace: molecular_function
def: "The catalysis of phosphate removal from a phosphotyrosine using aspartic acid as a nucleophile in a metal-dependent manner." [GOC:hjd]
xref: EC:3.1.3.-
is_a: GO:0004721 ! phosphoprotein phosphatase activity
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0019199
name: transmembrane receptor protein kinase activity
namespace: molecular_function
subset: gosubset_prok
xref: EC:2.7.11.-
is_a: GO:0004672 ! protein kinase activity
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0019200
name: carbohydrate kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl]
subset: gosubset_prok
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0019201
name: nucleotide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity

[Term]
id: GO:0019202
name: amino acid kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl]
subset: gosubset_prok
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0019203
name: carbohydrate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0019204
name: nucleotide phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate." [GOC:mah]
synonym: "polynucleotide phosphatase activity" EXACT [GOC:mah]
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0019205
name: nucleobase, nucleoside, nucleotide kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl]
subset: gosubset_prok
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0019206
name: nucleoside kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate." [GOC:ai]
subset: gosubset_prok
xref: Reactome:6991 "nucleoside kinase activity"
is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity

[Term]
id: GO:0019207
name: kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai]
subset: gosubset_prok
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0019208
name: phosphatase regulator activity
namespace: molecular_function
def: "Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0019209
name: kinase activator activity
namespace: molecular_function
def: "Increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0019207 ! kinase regulator activity

[Term]
id: GO:0019210
name: kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]
subset: gosubset_prok
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0019207 ! kinase regulator activity

[Term]
id: GO:0019211
name: phosphatase activator activity
namespace: molecular_function
def: "Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0019888 ! protein phosphatase regulator activity

[Term]
id: GO:0019212
name: phosphatase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0019888 ! protein phosphatase regulator activity

[Term]
id: GO:0019213
name: deacetylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0019214
name: surfactant activity
namespace: molecular_function
def: "OBSOLETE. The action of reducing the surface tension of a liquid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents involvement in a process.
is_obsolete: true
consider: GO:0050828

[Term]
id: GO:0019215
name: intermediate filament binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0019216
name: regulation of lipid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of lipid metabolism" EXACT []
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0006629 ! lipid metabolic process

[Term]
id: GO:0019217
name: regulation of fatty acid metabolic process
namespace: biological_process
alt_id: GO:0006632
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of fatty acid metabolism" EXACT []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
relationship: regulates GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0019218
name: regulation of steroid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of steroid metabolism" EXACT []
is_a: GO:0019216 ! regulation of lipid metabolic process
relationship: regulates GO:0008202 ! steroid metabolic process

[Term]
id: GO:0019219
name: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
namespace: biological_process
def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

[Term]
id: GO:0019220
name: regulation of phosphate metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of phosphate metabolism" EXACT []
is_a: GO:0051174 ! regulation of phosphorus metabolic process
relationship: regulates GO:0006796 ! phosphate metabolic process

[Term]
id: GO:0019221
name: cytokine-mediated signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor." [GOC:mah]
synonym: "cytokine and chemokine mediated signaling pathway" EXACT []
synonym: "cytokine mediated signalling pathway" EXACT []
is_a: GO:0023034 ! intracellular signaling pathway
is_a: GO:0023049 ! signal initiation by protein/peptide mediator

[Term]
id: GO:0019222
name: regulation of metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of metabolism" EXACT []
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0008152 ! metabolic process

[Term]
id: GO:0019226
name: transmission of nerve impulse
namespace: biological_process
def: "The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation." [http://cancerweb.ncl.ac.uk]
synonym: "signal transmission along a neuron" EXACT []
is_a: GO:0023060 ! signal transmission
is_a: GO:0050877 ! neurological system process
relationship: part_of GO:0007154 ! cell communication

[Term]
id: GO:0019227
name: neuronal action potential propagation
namespace: biological_process
def: "A neurological process that causes the sequential depolarization of a neuron's cell membrane along an axon." [GOC:isa_complete]
is_a: GO:0050877 ! neurological system process
relationship: part_of GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0019228
name: regulation of action potential in neuron
namespace: biological_process
def: "The process that modulates the membrane potential involved in the propagation of a signal in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb]
synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001508 ! regulation of action potential
relationship: part_of GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0019229
name: regulation of vasoconstriction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels." [GOC:jl]
is_a: GO:0044057 ! regulation of system process
relationship: regulates GO:0042310 ! vasoconstriction

[Term]
id: GO:0019230
name: proprioception
namespace: biological_process
def: "The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors." [http://www.onelook.com/, ISBN:072168677X]
xref: Wikipedia:Proprioception
is_a: GO:0007600 ! sensory perception
relationship: part_of GO:0050884 ! neuromuscular process controlling posture

[Term]
id: GO:0019231
name: perception of static position
namespace: biological_process
def: "The perception of the orientation of different parts of the body with respect to one another." [ISBN:072168677X]
is_a: GO:0019230 ! proprioception

[Term]
id: GO:0019232
name: perception of rate of movement
namespace: biological_process
def: "The series of events by which an organism senses the speed and direction of movement of the body and its parts." [GOC:mah]
synonym: "kinesthesia" EXACT []
is_a: GO:0019230 ! proprioception

[Term]
id: GO:0019233
name: sensory perception of pain
namespace: biological_process
def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." [http://www.onelook.com/]
synonym: "nociception" EXACT []
synonym: "perception of physiological pain" NARROW []
xref: Wikipedia:Nociception
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0019234
name: sensory perception of fast pain
namespace: biological_process
def: "The series of events required for an organism to receive a fast pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Fast pain is often subjectively described as a sharp or stabbing pain; in humans, the signals from a fast pain stimulus are perceived and relayed along myelinated A-delta fibers to the central nervous system, reaching their target in about 0.1 seconds." [http://www.spine-health.com/]
is_a: GO:0019233 ! sensory perception of pain

[Term]
id: GO:0019235
name: sensory perception of slow pain
namespace: biological_process
def: "The series of events required for an organism to receive a slow pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Slow pain is often subjectively described as an aching or throbbing pain; in humans, the signals from a slow pain stimulus are perceived and relayed along unmyelinated C fibers to the central nervous system, reaching their target in about 1 second. Slow pain is often associated with tissue destruction." [http://www.people.vcu.edu/~mikuleck/ssspain/, http://www.spine-health.com/]
is_a: GO:0019233 ! sensory perception of pain

[Term]
id: GO:0019236
name: response to pheromone
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl]
subset: gosubset_prok
synonym: "pheromone response" EXACT []
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0019237
name: centromeric DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis." [GOC:jl, SO:0000577]
synonym: "centromere binding" EXACT []
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0019238
name: cyclohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0019239
name: deaminase activity
namespace: molecular_function
def: "Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0019240
name: citrulline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "citrulline anabolism" EXACT []
synonym: "citrulline biosynthesis" EXACT []
synonym: "citrulline formation" EXACT []
synonym: "citrulline synthesis" EXACT []
xref: MetaCyc:CITRULBIO-PWY
is_a: GO:0000052 ! citrulline metabolic process
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process

[Term]
id: GO:0019241
name: citrulline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "citrulline breakdown" EXACT []
synonym: "citrulline catabolism" EXACT []
synonym: "citrulline degradation" EXACT []
xref: MetaCyc:CITRULLINE-DEG-PWY
is_a: GO:0000052 ! citrulline metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process

[Term]
id: GO:0019242
name: methylglyoxal biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai]
subset: gosubset_prok
synonym: "methylglyoxal anabolism" EXACT []
synonym: "methylglyoxal biosynthesis" EXACT []
synonym: "methylglyoxal formation" EXACT []
synonym: "methylglyoxal synthesis" EXACT []
is_a: GO:0009438 ! methylglyoxal metabolic process
is_a: GO:0046184 ! aldehyde biosynthetic process

[Term]
id: GO:0019243
name: methylglyoxal catabolic process to D-lactate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step." [GOC:ai]
subset: gosubset_prok
synonym: "D-lactate biosynthesis from methylglyoxal" EXACT []
synonym: "D-lactate biosynthetic process from methylglyoxal" EXACT []
synonym: "glyoxalase system" RELATED []
synonym: "methylglyoxal breakdown to D-lactate" EXACT []
synonym: "methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione" EXACT []
synonym: "methylglyoxal catabolism to D-lactate via S-lactoyl-glutathione" EXACT []
synonym: "methylglyoxal degradation to D-lactate" EXACT []
synonym: "methylglyoxal detoxification" RELATED []
xref: MetaCyc:PWY-901
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0051596 ! methylglyoxal catabolic process

[Term]
id: GO:0019244
name: lactate biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "lactate anabolism from pyruvate" EXACT []
synonym: "lactate formation from pyruvate" EXACT []
synonym: "lactate synthesis from pyruvate" EXACT []
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0019249 ! lactate biosynthetic process

[Term]
id: GO:0019245
name: D(-)-lactate biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D(-)-lactate from other compounds, including pyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "D(-)-lactate anabolism from pyruvate" EXACT []
synonym: "D(-)-lactate formation from pyruvate" EXACT []
synonym: "D(-)-lactate synthesis from pyruvate" EXACT []
is_a: GO:0019244 ! lactate biosynthetic process from pyruvate

[Term]
id: GO:0019246
name: L(+)-lactate biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L(+)lactate from other compounds, including pyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "L(+)-lactate anabolism from pyruvate" EXACT []
synonym: "L(+)-lactate formation from pyruvate" EXACT []
synonym: "L(+)-lactate synthesis from pyruvate" EXACT []
is_a: GO:0019244 ! lactate biosynthetic process from pyruvate

[Term]
id: GO:0019247
name: lactate racemization
namespace: biological_process
def: "Partial conversion of one lactate enantiomorph into another so that the specific optical rotation is decreased, or even reduced to zero, in the resulting mixture." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0006089 ! lactate metabolic process

[Term]
id: GO:0019248
name: D-lactate biosynthetic process from methylglyoxal via (R)-lactaldehyde
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-lactate from other compounds, including methylglyoxal, via the intermediate (R)-lactaldehyde." [GOC:go_curators]
subset: gosubset_prok
synonym: "D-lactate anabolism from methylglyoxal via (R)-lactaldehyde" EXACT []
synonym: "D-lactate formation from methylglyoxal via (R)-lactaldehyde" EXACT []
synonym: "D-lactate synthesis from methylglyoxal via (R)-lactaldehyde" EXACT []
xref: MetaCyc:MGLDLCTANA-PWY
is_a: GO:0019243 ! methylglyoxal catabolic process to D-lactate
is_a: GO:0019249 ! lactate biosynthetic process

[Term]
id: GO:0019249
name: lactate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "lactate anabolism" EXACT []
synonym: "lactate biosynthesis" EXACT []
synonym: "lactate formation" EXACT []
synonym: "lactate synthesis" EXACT []
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0019250
name: aerobic cobalamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the presence of oxygen." [GOC:go_curators]
subset: gosubset_prok
synonym: "aerobic cobalamin anabolism" EXACT []
synonym: "aerobic cobalamin biosynthesis" EXACT []
synonym: "aerobic cobalamin formation" EXACT []
synonym: "aerobic cobalamin synthesis" EXACT []
synonym: "aerobic vitamin B12 biosynthesis" EXACT []
synonym: "aerobic vitamin B12 biosynthetic process" EXACT []
synonym: "cobalamin biosynthesis, aerobic" EXACT []
synonym: "cobalamin biosynthetic process, aerobic" EXACT []
synonym: "vitamin B12 biosynthesis, aerobic" EXACT []
synonym: "vitamin B12 biosynthetic process, aerobic" EXACT []
xref: MetaCyc:P381-PWY
is_a: GO:0009236 ! cobalamin biosynthetic process

[Term]
id: GO:0019251
name: anaerobic cobalamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen." [GOC:go_curators]
subset: gosubset_prok
synonym: "anaerobic cobalamin anabolism" EXACT []
synonym: "anaerobic cobalamin biosynthesis" EXACT []
synonym: "anaerobic cobalamin formation" EXACT []
synonym: "anaerobic cobalamin synthesis" EXACT []
synonym: "anaerobic vitamin B12 biosynthesis" EXACT []
synonym: "anaerobic vitamin B12 biosynthetic process" EXACT []
synonym: "cobalamin biosynthesis, anaerobic" EXACT []
synonym: "cobalamin biosynthetic process, anaerobic" EXACT []
synonym: "vitamin B12 biosynthesis, anaerobic" EXACT []
synonym: "vitamin B12 biosynthetic process, anaerobic" EXACT []
xref: MetaCyc:COBALSYN-PWY
is_a: GO:0009236 ! cobalamin biosynthetic process

[Term]
id: GO:0019252
name: starch biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of starch, the most important reserve polysaccharide in plants." [GOC:ai]
subset: gosubset_prok
synonym: "starch anabolism" EXACT []
synonym: "starch biosynthesis" EXACT []
synonym: "starch formation" EXACT []
synonym: "starch synthesis" EXACT []
xref: MetaCyc:PWY-622
is_a: GO:0005982 ! starch metabolic process
is_a: GO:0009250 ! glucan biosynthetic process

[Term]
id: GO:0019253
name: reductive pentose-phosphate cycle
namespace: biological_process
def: "The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate." [ISBN:0198547684]
comment: See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'.
synonym: "C3 photosynthesis" NARROW []
synonym: "Calvin cycle" NARROW []
xref: MetaCyc:CALVIN-PWY
is_a: GO:0019685 ! photosynthesis, dark reaction
relationship: part_of GO:0015977 ! carbon utilization by fixation of carbon dioxide

[Term]
id: GO:0019254
name: carnitine metabolic process, CoA-linked
namespace: biological_process
def: "The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA." [GOC:go_curators]
subset: gosubset_prok
synonym: "carnitine metabolism, CoA-linked" EXACT []
xref: MetaCyc:CARNMET-PWY
is_a: GO:0009437 ! carnitine metabolic process

[Term]
id: GO:0019255
name: glucose 1-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1." [GOC:ai]
subset: gosubset_prok
synonym: "glucose 1-phosphate metabolism" EXACT []
xref: MetaCyc:GLUCOSE1PMETAB-PWY
is_a: GO:0006006 ! glucose metabolic process

[Term]
id: GO:0019256
name: acrylonitrile catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [GOC:ai]
subset: gosubset_prok
synonym: "acrylonitrile breakdown" EXACT []
synonym: "acrylonitrile catabolism" EXACT []
synonym: "acrylonitrile degradation" EXACT []
xref: MetaCyc:P344-PWY
is_a: GO:0018865 ! acrylonitrile metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0050899 ! nitrile catabolic process

[Term]
id: GO:0019257
name: 4-nitrotoluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-nitrotoluene, 1-methyl-4-nitrobenzene. It is a light yellow liquid with a weak aromatic odor." [GOC:ai]
subset: gosubset_prok
synonym: "4-nitrotoluene metabolism" EXACT []
synonym: "4NT metabolic process" EXACT []
synonym: "4NT metabolism" EXACT []
is_a: GO:0019326 ! nitrotoluene metabolic process

[Term]
id: GO:0019258
name: 4-nitrotoluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 4-nitrotoluene, 1-methyl-4-nitrobenzene." [GOC:ai]
subset: gosubset_prok
synonym: "4-nitrotoluene breakdown" EXACT []
synonym: "4-nitrotoluene catabolism" EXACT []
synonym: "4-nitrotoluene degradation" EXACT []
synonym: "4NT catabolic process" EXACT []
synonym: "4NT catabolism" EXACT []
xref: MetaCyc:P421-PWY
is_a: GO:0019257 ! 4-nitrotoluene metabolic process
is_a: GO:0046263 ! nitrotoluene catabolic process

[Term]
id: GO:0019260
name: 1,2-dichloroethane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:go_curators]
subset: gosubset_prok
synonym: "1,2-dichloroethane breakdown" EXACT []
synonym: "1,2-dichloroethane catabolism" EXACT []
synonym: "1,2-dichloroethane degradation" EXACT []
xref: MetaCyc:12DICHLORETHDEG-PWY
is_a: GO:0018899 ! 1,2-dichloroethane metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process

[Term]
id: GO:0019261
name: 1,4-dichlorobenzene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring." [GOC:ai]
subset: gosubset_prok
synonym: "1,4-dichlorobenzene breakdown" EXACT []
synonym: "1,4-dichlorobenzene catabolism" EXACT []
synonym: "1,4-dichlorobenzene degradation" EXACT []
xref: MetaCyc:14DICHLORBENZDEG-PWY
is_a: GO:0018912 ! 1,4-dichlorobenzene metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process
is_a: GO:0043451 ! alkene catabolic process

[Term]
id: GO:0019262
name: N-acetylneuraminate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "N-acetylneuraminate breakdown" EXACT []
synonym: "N-acetylneuraminate catabolism" EXACT []
synonym: "N-acetylneuraminate degradation" EXACT []
xref: MetaCyc:P441-PWY
is_a: GO:0006054 ! N-acetylneuraminate metabolic process
is_a: GO:0046348 ! amino sugar catabolic process

[Term]
id: GO:0019263
name: adamantanone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai]
subset: gosubset_prok
synonym: "adamantanone breakdown" EXACT []
synonym: "adamantanone catabolism" EXACT []
synonym: "adamantanone degradation" EXACT []
xref: MetaCyc:P481-PWY
is_a: GO:0018866 ! adamantanone metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042182 ! ketone catabolic process

[Term]
id: GO:0019264
name: glycine biosynthetic process from serine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycine anabolism from serine" EXACT []
synonym: "glycine formation from serine" EXACT []
synonym: "glycine synthesis from serine" EXACT []
xref: MetaCyc:GLYSYN-PWY
is_a: GO:0006545 ! glycine biosynthetic process
is_a: GO:0006563 ! L-serine metabolic process

[Term]
id: GO:0019265
name: glycine biosynthetic process, by transamination of glyoxylate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycine anabolism, by transamination of glyoxylate" EXACT []
synonym: "glycine formation, by transamination of glyoxylate" EXACT []
synonym: "glycine synthesis, by transamination of glyoxylate" EXACT []
is_a: GO:0006545 ! glycine biosynthetic process

[Term]
id: GO:0019266
name: asparagine biosynthetic process from oxaloacetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "asparagine anabolism from oxaloacetate" EXACT []
synonym: "asparagine formation from oxaloacetate" EXACT []
synonym: "asparagine synthesis from oxaloacetate" EXACT []
xref: MetaCyc:ASPARAGINE-BIOSYNTHESIS
is_a: GO:0006107 ! oxaloacetate metabolic process
is_a: GO:0006529 ! asparagine biosynthetic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process

[Term]
id: GO:0019267
name: asparagine biosynthetic process from cysteine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including cysteine." [GOC:go_curators]
subset: gosubset_prok
synonym: "asparagine anabolism from cysteine" EXACT []
synonym: "asparagine formation from cysteine" EXACT []
synonym: "asparagine synthesis from cysteine" EXACT []
xref: MetaCyc:ASPSYNII-PWY
is_a: GO:0006529 ! asparagine biosynthetic process
is_a: GO:0006534 ! cysteine metabolic process

[Term]
id: GO:0019268
name: glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate dehydrogenase (NADP+)." [GOC:go_curators]
comment: This term was made obsolete because it represents a molecular function.
synonym: "glutamate anabolism, using glutamate dehydrogenase (NAD(P)+)" EXACT []
synonym: "glutamate formation, using glutamate dehydrogenase (NAD(P)+)" EXACT []
synonym: "glutamate synthesis, using glutamate dehydrogenase (NAD(P)+)" EXACT []
is_obsolete: true
replaced_by: GO:0004353
replaced_by: GO:0006537

[Term]
id: GO:0019269
name: glutamate biosynthetic process, using glutamate synthase (NADPH)
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate synthase (NADPH)." [GOC:go_curators]
comment: This term was made obsolete because it refers to a molecular function.
synonym: "glutamate anabolism, using glutamate synthase (NADPH)" EXACT []
synonym: "glutamate formation, using glutamate synthase (NADPH)" EXACT []
synonym: "glutamate synthesis, using glutamate synthase (NADPH)" EXACT []
is_obsolete: true
replaced_by: GO:0004355
replaced_by: GO:0006537

[Term]
id: GO:0019270
name: aerobactin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai]
subset: gosubset_prok
synonym: "aerobactin anabolism" EXACT []
synonym: "aerobactin biosynthesis" EXACT []
synonym: "aerobactin formation" EXACT []
synonym: "aerobactin synthesis" EXACT []
xref: MetaCyc:AEROBACTINSYN-PWY
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process
is_a: GO:0046442 ! aerobactin metabolic process

[Term]
id: GO:0019271
name: aerobactin transport
namespace: biological_process
def: "The directed movement of the hydroxamate iron transport compound aerobactin into, out of, within or between cells by means of some external agent such as a transporter or pore. Aerobactin (C22H36N4O13) is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai]
is_a: GO:0006810 ! transport

[Term]
id: GO:0019272
name: L-alanine biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alanine from other compounds, including pyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-alanine anabolism from pyruvate" EXACT []
synonym: "L-alanine formation from pyruvate" EXACT []
synonym: "L-alanine synthesis from pyruvate" EXACT []
xref: MetaCyc:ALANINE-SYN2-PWY
xref: MetaCyc:ALANINE-VALINESYN-PWY
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0042852 ! L-alanine biosynthetic process

[Term]
id: GO:0019273
name: L-alanine biosynthetic process via ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-alanine, via the intermediate ornithine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-alanine anabolism via ornithine" EXACT []
synonym: "L-alanine formation via ornithine" EXACT []
synonym: "L-alanine synthesis via ornithine" EXACT []
is_a: GO:0006591 ! ornithine metabolic process
is_a: GO:0042852 ! L-alanine biosynthetic process

[Term]
id: GO:0019276
name: UDP-N-acetylgalactosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-N-acetylgalactosamine metabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0019277
name: UDP-N-acetylgalactosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-N-acetylgalactosamine anabolism" EXACT []
synonym: "UDP-N-acetylgalactosamine biosynthesis" EXACT []
synonym: "UDP-N-acetylgalactosamine formation" EXACT []
synonym: "UDP-N-acetylgalactosamine synthesis" EXACT []
xref: MetaCyc:UDPNACETYLGALSYN-PWY
is_a: GO:0019276 ! UDP-N-acetylgalactosamine metabolic process
is_a: GO:0046349 ! amino sugar biosynthetic process

[Term]
id: GO:0019278
name: UDP-N-acetylgalactosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-N-acetylgalactosamine breakdown" EXACT []
synonym: "UDP-N-acetylgalactosamine catabolism" EXACT []
synonym: "UDP-N-acetylgalactosamine degradation" EXACT []
is_a: GO:0019276 ! UDP-N-acetylgalactosamine metabolic process
is_a: GO:0046348 ! amino sugar catabolic process

[Term]
id: GO:0019279
name: L-methionine biosynthetic process from L-homoserine via cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including L-homoserine, via the intermediate cystathionine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-methionine anabolism from L-homoserine via cystathionine" EXACT [GOC:mah]
synonym: "L-methionine formation from L-homoserine via cystathionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from L-homoserine via cystathionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from L-homoserine via cystathionine" EXACT [GOC:mah]
xref: MetaCyc:HOMOSER-METSYN-PWY
is_a: GO:0009092 ! homoserine metabolic process
is_a: GO:0071266 ! 'de novo' L-methionine biosynthetic process

[Term]
id: GO:0019280
name: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-acetyl-L-homoserine and cystathionine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-methionine anabolism from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine formation from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah]
xref: MetaCyc:HSERMETANA-PWY
is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine

[Term]
id: GO:0019281
name: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-methionine anabolism from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine formation from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah]
xref: MetaCyc:MET-SAM-PWY
is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine

[Term]
id: GO:0019282
name: L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine
namespace: biological_process
def: "The direct chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including O-acetyl-L-homoserine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-methionine anabolism, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah]
synonym: "L-methionine formation, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah]
synonym: "L-methionine synthesis, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah]
is_a: GO:0071266 ! 'de novo' L-methionine biosynthetic process

[Term]
id: GO:0019283
name: L-methionine biosynthetic process from O-phospho-L-homoserine and cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including O-phospho-L-homoserine and cystathionine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-methionine anabolism from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine formation from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
is_a: GO:0071266 ! 'de novo' L-methionine biosynthetic process

[Term]
id: GO:0019284
name: L-methionine biosynthetic process from S-adenosylmethionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including S-adenosylmethionine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-methionine anabolism from S-adenosylmethionine" EXACT [GOC:mah]
synonym: "L-methionine biosynthesis from S-adenosyl methionine" EXACT [GOC:mah]
synonym: "L-methionine biosynthetic process from S-adenosyl methionine" EXACT [GOC:mah]
synonym: "L-methionine formation from S-adenosylmethionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from S-adenosylmethionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from S-adenosylmethionine" EXACT [GOC:mah]
is_a: GO:0046500 ! S-adenosylmethionine metabolic process
is_a: GO:0071267 ! L-methionine salvage
relationship: part_of GO:0033353 ! S-adenosylmethionine cycle

[Term]
id: GO:0019285
name: glycine betaine biosynthetic process from choline
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline." [GOC:jl]
subset: gosubset_prok
synonym: "glycine betaine anabolism from choline" EXACT []
synonym: "glycine betaine formation from choline" EXACT []
synonym: "glycine betaine synthesis from choline" EXACT []
synonym: "N-trimethylglycine biosynthesis from choline" EXACT []
synonym: "N-trimethylglycine biosynthetic process from choline" EXACT []
xref: MetaCyc:BETSYN-PWY
xref: MetaCyc:CHOLINE-BETAINE-ANA-PWY
xref: MetaCyc:P542-PWY
is_a: GO:0019695 ! choline metabolic process
is_a: GO:0031456 ! glycine betaine biosynthetic process

[Term]
id: GO:0019286
name: glycine betaine biosynthetic process from glycine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycine betaine from other compounds, including glycine." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycine betaine anabolism from glycine" EXACT []
synonym: "glycine betaine formation from glycine" EXACT []
synonym: "glycine betaine synthesis from glycine" EXACT []
synonym: "N-trimethylglycine biosynthesis from glycine" EXACT []
synonym: "N-trimethylglycine biosynthetic process from glycine" EXACT []
xref: MetaCyc:P541-PWY
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0031456 ! glycine betaine biosynthetic process

[Term]
id: GO:0019287
name: isopentenyl diphosphate biosynthetic process, mevalonate pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates." [GOC:go_curators, MetaCyc:PWY-922]
subset: gosubset_prok
synonym: "Ac-MVA pathway" EXACT [PMID:14517367]
synonym: "acetate-mevalonate pathway" EXACT [PMID:14517367]
synonym: "isopentenyl diphosphate anabolism, mevalonate pathway" EXACT []
synonym: "isopentenyl diphosphate formation, mevalonate pathway" EXACT []
synonym: "isopentenyl diphosphate synthesis, mevalonate pathway" EXACT []
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process

[Term]
id: GO:0019288
name: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate." [GOC:go_curators, MetaCyc:NONMEVIPP-PWY]
subset: gosubset_prok
synonym: "isopentenyl diphosphate anabolism, mevalonate-independent pathway" EXACT []
synonym: "isopentenyl diphosphate biosynthesis, mevalonate-independent" EXACT []
synonym: "isopentenyl diphosphate biosynthesis, non-mevalonate pathway" EXACT []
synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent" EXACT []
synonym: "isopentenyl diphosphate biosynthetic process, non-mevalonate pathway" EXACT []
synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway" EXACT []
synonym: "isopentenyl diphosphate synthesis, mevalonate-independent pathway" EXACT []
synonym: "mevalonate-independent isopentenyl diphosphate biosynthesis" EXACT []
synonym: "mevalonate-independent isopentenyl diphosphate biosynthetic process" EXACT []
synonym: "non-MVA pathway" EXACT []
xref: MetaCyc:NONMEVIPP-PWY
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process

[Term]
id: GO:0019289
name: rhizobactin 1021 biosynthetic process
namespace: biological_process
alt_id: GO:0031193
alt_id: GO:0031194
def: "The chemical reactions and pathways resulting in the formation of rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [MetaCyc:PWY-761, PMID:11274118]
subset: gosubset_prok
synonym: "rhizobactin 1021 anabolism" EXACT []
synonym: "rhizobactin 1021 biosynthesis" EXACT []
synonym: "rhizobactin 1021 biosynthetic process, peptide formation" NARROW []
synonym: "rhizobactin 1021 biosynthetic process, peptide modification" NARROW []
synonym: "rhizobactin 1021 formation" EXACT []
synonym: "rhizobactin 1021 synthesis" EXACT []
xref: MetaCyc:PWY-761
is_a: GO:0019540 ! siderophore biosynthetic process from catechol
is_a: GO:0046494 ! rhizobactin 1021 metabolic process

[Term]
id: GO:0019290
name: siderophore biosynthetic process
namespace: biological_process
alt_id: GO:0031178
alt_id: GO:0031180
def: "The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [GOC:go_curators]
comment: See also the biological process term 'nonribosomal peptide biosynthetic process ; GO:0019184'.
subset: gosubset_prok
synonym: "siderochrome biosynthesis" NARROW []
synonym: "siderochrome biosynthetic process" NARROW []
synonym: "siderophore anabolism" EXACT []
synonym: "siderophore biosynthesis" EXACT []
synonym: "siderophore biosynthetic process, peptide formation" NARROW []
synonym: "siderophore biosynthetic process, peptide modification" NARROW []
synonym: "siderophore formation" EXACT []
synonym: "siderophore synthesis" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0019184 ! nonribosomal peptide biosynthetic process
is_a: GO:0051188 ! cofactor biosynthetic process

[Term]
id: GO:0019292
name: tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate 4-hydroxyphenylpyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "tyrosine anabolism from chorismate via 4-hydroxyphenylpyruvate" EXACT []
synonym: "tyrosine biosynthetic process from chorismate via p-hydroxyphenylpyruvate" EXACT []
synonym: "tyrosine formation from chorismate via 4-hydroxyphenylpyruvate" EXACT []
synonym: "tyrosine synthesis from chorismate via 4-hydroxyphenylpyruvate" EXACT []
xref: MetaCyc:TYRSYN
is_a: GO:0006571 ! tyrosine biosynthetic process

[Term]
id: GO:0019293
name: tyrosine biosynthetic process, by oxidation of phenylalanine
namespace: biological_process
alt_id: GO:0019291
def: "The chemical reactions and pathways resulting in the formation of tyrosine by the oxidation of phenylalanine." [GOC:go_curators]
subset: gosubset_prok
synonym: "tyrosine anabolism from chorismate via L-phenylalanine" EXACT []
synonym: "tyrosine anabolism, by oxidation of phenylalanine" EXACT []
synonym: "tyrosine biosynthetic process from chorismate via L-phenylalanine" EXACT []
synonym: "tyrosine formation from chorismate via L-phenylalanine" EXACT []
synonym: "tyrosine formation, by oxidation of phenylalanine" EXACT []
synonym: "tyrosine synthesis from chorismate via L-phenylalanine" EXACT []
synonym: "tyrosine synthesis, by oxidation of phenylalanine" EXACT []
is_a: GO:0006558 ! L-phenylalanine metabolic process
is_a: GO:0006571 ! tyrosine biosynthetic process

[Term]
id: GO:0019294
name: keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria." [ChEBI:32817, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "KDO biosynthesis" EXACT []
synonym: "KDO biosynthetic process" EXACT []
synonym: "keto-3-deoxy-D-manno-octulosonic acid anabolism" EXACT []
synonym: "keto-3-deoxy-D-manno-octulosonic acid biosynthesis" EXACT []
synonym: "keto-3-deoxy-D-manno-octulosonic acid formation" EXACT []
synonym: "keto-3-deoxy-D-manno-octulosonic acid synthesis" EXACT []
synonym: "ketodeoxyoctanoate biosynthetic process" RELATED [ISBN:0198506732]
xref: MetaCyc:KDOSYN-PWY
is_a: GO:0046364 ! monosaccharide biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0046400 ! keto-3-deoxy-D-manno-octulosonic acid metabolic process
relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process

[Term]
id: GO:0019295
name: coenzyme M biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [ISBN:0198547684]
subset: gosubset_prok
synonym: "coenzyme M anabolism" EXACT []
synonym: "coenzyme M biosynthesis" EXACT []
synonym: "coenzyme M formation" EXACT []
synonym: "coenzyme M synthesis" EXACT []
xref: MetaCyc:P261-PWY
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0019296 ! coenzyme M metabolic process

[Term]
id: GO:0019296
name: coenzyme M metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators]
subset: gosubset_prok
synonym: "coenzyme M metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process

[Term]
id: GO:0019297
name: coenzyme B metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators]
subset: gosubset_prok
synonym: "coenzyme B metabolism" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0006732 ! coenzyme metabolic process

[Term]
id: GO:0019298
name: coenzyme B biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [PMID:10940051]
subset: gosubset_prok
synonym: "coenzyme B anabolism" EXACT []
synonym: "coenzyme B biosynthesis" EXACT []
synonym: "coenzyme B formation" EXACT []
synonym: "coenzyme B synthesis" EXACT []
xref: MetaCyc:P241-PWY
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0019297 ! coenzyme B metabolic process
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process

[Term]
id: GO:0019299
name: rhamnose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "rhamnose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0019300
name: rhamnose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of rhamnose, the hexose 6-deoxy-L-mannose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "rhamnose anabolism" EXACT []
synonym: "rhamnose biosynthesis" EXACT []
synonym: "rhamnose formation" EXACT []
synonym: "rhamnose synthesis" EXACT []
is_a: GO:0019299 ! rhamnose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0019301
name: rhamnose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "rhamnose breakdown" EXACT []
synonym: "rhamnose catabolism" EXACT []
synonym: "rhamnose degradation" EXACT []
xref: MetaCyc:RHAMCAT-PWY
is_a: GO:0019299 ! rhamnose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0019302
name: D-ribose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-ribose, (ribo-pentose)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-ribose anabolism" EXACT []
synonym: "D-ribose biosynthesis" EXACT []
synonym: "D-ribose formation" EXACT []
synonym: "D-ribose synthesis" EXACT []
is_a: GO:0006014 ! D-ribose metabolic process
is_a: GO:0019322 ! pentose biosynthetic process

[Term]
id: GO:0019303
name: D-ribose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-ribose (ribo-pentose)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-ribose breakdown" EXACT []
synonym: "D-ribose catabolism" EXACT []
synonym: "D-ribose degradation" EXACT []
xref: MetaCyc:RIBOKIN-PWY
is_a: GO:0006014 ! D-ribose metabolic process
is_a: GO:0019323 ! pentose catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0019304
name: anaerobic rhamnose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose, that occurs in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic rhamnose breakdown" EXACT []
synonym: "anaerobic rhamnose catabolism" EXACT []
synonym: "anaerobic rhamnose degradation" EXACT []
is_a: GO:0019301 ! rhamnose catabolic process

[Term]
id: GO:0019305
name: dTDP-rhamnose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "dTDP-rhamnose anabolism" EXACT []
synonym: "dTDP-rhamnose biosynthesis" EXACT []
synonym: "dTDP-rhamnose formation" EXACT []
synonym: "dTDP-rhamnose synthesis" EXACT []
xref: MetaCyc:DTDPRHAMSYN-PWY
xref: MetaCyc:PWY-3221
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0019300 ! rhamnose biosynthetic process
is_a: GO:0046383 ! dTDP-rhamnose metabolic process

[Term]
id: GO:0019306
name: GDP-D-rhamnose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP-D-rhamnose anabolism" EXACT []
synonym: "GDP-D-rhamnose biosynthesis" EXACT []
synonym: "GDP-D-rhamnose formation" EXACT []
synonym: "GDP-D-rhamnose synthesis" EXACT []
xref: MetaCyc:GDPRHAMSYN-PWY
is_a: GO:0006002 ! fructose 6-phosphate metabolic process
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0019300 ! rhamnose biosynthetic process
is_a: GO:0046382 ! GDP-D-rhamnose metabolic process

[Term]
id: GO:0019307
name: mannose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai]
subset: gosubset_prok
synonym: "mannose anabolism" EXACT []
synonym: "mannose biosynthesis" EXACT []
synonym: "mannose formation" EXACT []
synonym: "mannose synthesis" EXACT []
is_a: GO:0006013 ! mannose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0019308
name: dTDP-mannose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "dTDP-mannose anabolism" EXACT []
synonym: "dTDP-mannose biosynthesis" EXACT []
synonym: "dTDP-mannose formation" EXACT []
synonym: "dTDP-mannose synthesis" EXACT []
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0019307 ! mannose biosynthetic process
is_a: GO:0046371 ! dTDP-mannose metabolic process

[Term]
id: GO:0019309
name: mannose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai]
subset: gosubset_prok
synonym: "mannose breakdown" EXACT []
synonym: "mannose catabolism" EXACT []
synonym: "mannose degradation" EXACT []
xref: MetaCyc:MANNCAT-PWY
is_a: GO:0006013 ! mannose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0019310
name: inositol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ChEBI:24848, GOC:go_curators]
subset: gosubset_prok
synonym: "inositol breakdown" EXACT []
synonym: "inositol catabolism" EXACT []
synonym: "inositol degradation" EXACT []
synonym: "myo-inositol catabolic process" NARROW []
synonym: "myo-inositol catabolism" NARROW []
synonym: "vitamin Bh catabolic process" EXACT []
synonym: "vitamin Bh catabolism" EXACT []
xref: MetaCyc:P562-PWY
is_a: GO:0006020 ! inositol metabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process
is_a: GO:0046174 ! polyol catabolic process

[Term]
id: GO:0019311
name: sorbose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sorbose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0019312
name: L-sorbose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol." [ChEBI:17266, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "L-sorbose metabolism" EXACT []
xref: MetaCyc:P302-PWY
is_a: GO:0019311 ! sorbose metabolic process

[Term]
id: GO:0019313
name: allose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "allose metabolism" EXACT []
is_a: GO:0019318 ! hexose metabolic process

[Term]
id: GO:0019314
name: D-allose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [ChEBI:17393, GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-allose metabolism" EXACT []
is_a: GO:0019313 ! allose metabolic process

[Term]
id: GO:0019315
name: D-allose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [ChEBI:17393, GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-allose anabolism" EXACT []
synonym: "D-allose biosynthesis" EXACT []
synonym: "D-allose formation" EXACT []
synonym: "D-allose synthesis" EXACT []
is_a: GO:0019314 ! D-allose metabolic process
is_a: GO:0046366 ! allose biosynthetic process

[Term]
id: GO:0019316
name: D-allose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [ChEBI:17393, GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-allose breakdown" EXACT []
synonym: "D-allose catabolism" EXACT []
synonym: "D-allose degradation" EXACT []
xref: MetaCyc:PWY0-44
is_a: GO:0019314 ! D-allose metabolic process
is_a: GO:0046367 ! allose catabolic process

[Term]
id: GO:0019317
name: fucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose)." [GOC:jl]
subset: gosubset_prok
synonym: "fucose breakdown" EXACT []
synonym: "fucose catabolism" EXACT []
synonym: "fucose degradation" EXACT []
xref: MetaCyc:FUCCAT-PWY
is_a: GO:0006004 ! fucose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0019318
name: hexose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "hexose metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process

[Term]
id: GO:0019319
name: hexose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "hexose anabolism" EXACT []
synonym: "hexose biosynthesis" EXACT []
synonym: "hexose formation" EXACT []
synonym: "hexose synthesis" EXACT []
is_a: GO:0019318 ! hexose metabolic process
is_a: GO:0046364 ! monosaccharide biosynthetic process

[Term]
id: GO:0019320
name: hexose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "hexose breakdown" EXACT []
synonym: "hexose catabolism" EXACT []
synonym: "hexose degradation" EXACT []
is_a: GO:0019318 ! hexose metabolic process
is_a: GO:0046365 ! monosaccharide catabolic process

[Term]
id: GO:0019321
name: pentose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pentose metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process

[Term]
id: GO:0019322
name: pentose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pentose anabolism" EXACT []
synonym: "pentose biosynthesis" EXACT []
synonym: "pentose formation" EXACT []
synonym: "pentose synthesis" EXACT []
is_a: GO:0019321 ! pentose metabolic process
is_a: GO:0046364 ! monosaccharide biosynthetic process

[Term]
id: GO:0019323
name: pentose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pentose breakdown" EXACT []
synonym: "pentose catabolism" EXACT []
synonym: "pentose degradation" EXACT []
is_a: GO:0019321 ! pentose metabolic process
is_a: GO:0046365 ! monosaccharide catabolic process

[Term]
id: GO:0019324
name: L-lyxose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-lyxose, the L-enantiomer of aldopentose lyxo-pentose, the C-2 epimer of xylose." [GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "L-lyxose metabolism" EXACT []
xref: MetaCyc:LYXMET-PWY
is_a: GO:0019321 ! pentose metabolic process

[Term]
id: GO:0019325
name: anaerobic fructose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic fructose breakdown" EXACT []
synonym: "anaerobic fructose catabolism" EXACT []
synonym: "anaerobic fructose degradation" EXACT []
xref: MetaCyc:ANAEROFRUCAT-PWY
is_a: GO:0006001 ! fructose catabolic process
is_a: GO:0019317 ! fucose catabolic process

[Term]
id: GO:0019326
name: nitrotoluene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai]
subset: gosubset_prok
synonym: "nitrotoluene metabolism" EXACT []
is_a: GO:0018970 ! toluene metabolic process

[Term]
id: GO:0019327
name: oxidation of lead sulfide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of lead sulfide to lead sulfate." [MetaCyc:P301-PWY]
subset: gosubset_prok
synonym: "oxidation of galena" EXACT []
synonym: "oxidation of lead sulphide" EXACT []
xref: MetaCyc:P301-PWY
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0019328
name: anaerobic gallate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the absence of oxygen." [GOC:jl]
subset: gosubset_prok
synonym: "anaerobic gallate breakdown" EXACT []
synonym: "anaerobic gallate catabolism" EXACT []
synonym: "anaerobic gallate degradation" EXACT []
synonym: "anaerobic gallic acid catabolic process" EXACT []
synonym: "anaerobic gallic acid catabolism" EXACT []
synonym: "gallate fermentation" EXACT []
xref: MetaCyc:P3-PWY
is_a: GO:0019396 ! gallate catabolic process

[Term]
id: GO:0019329
name: ammonia oxidation
namespace: biological_process
def: "The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons." [GOC:mah, MetaCyc:AMMOXID-PWY, MetaCyc:P303-PWY, MetaCyc:PWY-2242]
subset: gosubset_prok
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0019330
name: aldoxime metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aldoximes, compounds derived by the reaction of an aldose with hydroxylamine, thus containing the aldoxime group -HC=NOH." [http://cancerweb.ncl.ac.uk/]
synonym: "aldoxime metabolism" EXACT []
xref: MetaCyc:P345-PWY
is_a: GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0019331
name: anaerobic respiration, using ammonium as electron donor
namespace: biological_process
def: "The oxidation of ammonium (NH4) to nitrogen (N2) in the absence of oxygen, using nitrite (NO2) as the electron acceptor. It is suggested that hydroxylamine and ammonium are combined to yield hydrazine, which is subsequently oxidized to N2." [MetaCyc:P303-PWY]
subset: gosubset_prok
synonym: "anaerobic ammonium oxidation" BROAD []
synonym: "anammox" EXACT []
xref: MetaCyc:P303-PWY
xref: Wikipedia:Anammox
is_a: GO:0009061 ! anaerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds
is_a: GO:0019329 ! ammonia oxidation
is_a: GO:0034641 ! cellular nitrogen compound metabolic process

[Term]
id: GO:0019332
name: aerobic respiration, using nitrite as electron donor
namespace: biological_process
def: "The oxidation of nitrite (NO2) to nitrate (NO3), using oxygen (O2) as the electron acceptor. Nitrite oxidation is the final step in nitrification, the oxidation of ammonia to nitrate, and nitrite oxidoreductase (NOR) is the key enzyme complex that catalyzes the conversion of nitrite to nitrate in nitrite oxidizing species." [MetaCyc:P282-PWY]
subset: gosubset_prok
synonym: "nitrite oxidation" BROAD []
xref: MetaCyc:P282-PWY
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds
is_a: GO:0034641 ! cellular nitrogen compound metabolic process

[Term]
id: GO:0019333
name: denitrification pathway
namespace: biological_process
def: "The reduction of nitrate to dinitrogen by four reactions; each intermediate is transformed to the next lower oxidation state; also part of cellular bioenergetics; the nitrogen compounds can serve as terminal acceptors for electron transport phosphorylation in place of oxygen." [MetaCyc:DENITRIFICATION-PWY]
xref: MetaCyc:DENITRIFICATION-PWY
is_a: GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0019334
name: p-cymene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants." [GOC:ai]
subset: gosubset_prok
synonym: "p-cymene breakdown" EXACT []
synonym: "p-cymene catabolism" EXACT []
synonym: "p-cymene degradation" EXACT []
xref: MetaCyc:PWY-741
is_a: GO:0018953 ! p-cymene metabolic process
is_a: GO:0042203 ! toluene catabolic process

[Term]
id: GO:0019335
name: 3-methylquinoline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring." [GOC:ai]
subset: gosubset_prok
synonym: "3-methylquinoline breakdown" EXACT []
synonym: "3-methylquinoline catabolism" EXACT []
synonym: "3-methylquinoline degradation" EXACT []
xref: MetaCyc:PWY-721
is_a: GO:0018930 ! 3-methylquinoline metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0019336
name: phenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "carbolic acid catabolic process" EXACT []
synonym: "carbolic acid catabolism" EXACT []
synonym: "hydroxybenzene catabolic process" EXACT []
synonym: "hydroxybenzene catabolism" EXACT []
synonym: "phenol breakdown" EXACT []
synonym: "phenol catabolism" EXACT []
synonym: "phenol degradation" EXACT []
xref: MetaCyc:PHENOLDEG-PWY
is_a: GO:0018958 ! phenol metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0019337
name: tetrachloroethylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines." [GOC:ai]
subset: gosubset_prok
synonym: "tetrachloroethene catabolic process" EXACT []
synonym: "tetrachloroethene catabolism" EXACT []
synonym: "tetrachloroethylene breakdown" EXACT []
synonym: "tetrachloroethylene catabolism" EXACT []
synonym: "tetrachloroethylene degradation" EXACT []
xref: MetaCyc:PCEDEG-PWY
is_a: GO:0018967 ! tetrachloroethylene metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process
is_a: GO:0043451 ! alkene catabolic process

[Term]
id: GO:0019338
name: pentachlorophenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [GOC:go_curators]
subset: gosubset_prok
synonym: "pentachlorophenol breakdown" EXACT []
synonym: "pentachlorophenol catabolism" EXACT []
synonym: "pentachlorophenol degradation" EXACT []
xref: MetaCyc:PCPDEG-PWY
is_a: GO:0018961 ! pentachlorophenol metabolic process
is_a: GO:0019336 ! phenol catabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process

[Term]
id: GO:0019339
name: parathion catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [http://umbbd.ahc.umn.edu/pthn/pthn_map.html, UM-BBD_pathwayID:pthn]
subset: gosubset_prok
synonym: "parathion breakdown" EXACT []
synonym: "parathion catabolism" EXACT []
synonym: "parathion degradation" EXACT []
xref: MetaCyc:PARATHION-DEGRADATION-PWY
is_a: GO:0018952 ! parathion metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0019340
name: dibenzofuran catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond." [GOC:ai]
subset: gosubset_prok
synonym: "dibenzofuran breakdown" EXACT []
synonym: "dibenzofuran catabolism" EXACT []
synonym: "dibenzofuran degradation" EXACT []
xref: MetaCyc:P662-PWY
is_a: GO:0018893 ! dibenzofuran metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0019341
name: dibenzo-p-dioxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds." [GOC:ai]
subset: gosubset_prok
synonym: "dibenzo-p-dioxin breakdown" EXACT []
synonym: "dibenzo-p-dioxin catabolism" EXACT []
synonym: "dibenzo-p-dioxin degradation" EXACT []
xref: MetaCyc:P661-PWY
is_a: GO:0018894 ! dibenzo-p-dioxin metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0019342
name: trypanothione biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trypanothione (N1,N6,-bis(glutathionyl)spermidine) in two steps from glutathione and spermidine via an N1- or N8-glutathionylspermidine intermediate. Trypanothione appears to be an essential redox intermediate in intracellular thiol redox regulation. It also plays a role in protecting against oxidative stress." [MetaCyc:TRYPANOSYN-PWY, PMID:9677355]
subset: gosubset_prok
synonym: "trypanothione anabolism" EXACT []
synonym: "trypanothione biosynthesis" EXACT []
synonym: "trypanothione formation" EXACT []
synonym: "trypanothione synthesis" EXACT []
xref: MetaCyc:TRYPANOSYN-PWY
is_a: GO:0008295 ! spermidine biosynthetic process
is_a: GO:0046206 ! trypanothione metabolic process

[Term]
id: GO:0019343
name: cysteine biosynthetic process via cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine." [GOC:go_curators]
subset: gosubset_prok
synonym: "cysteine anabolism via cystathionine" EXACT []
synonym: "cysteine formation via cystathionine" EXACT []
synonym: "cysteine synthesis via cystathionine" EXACT []
is_a: GO:0019344 ! cysteine biosynthetic process

[Term]
id: GO:0019344
name: cysteine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "cysteine anabolism" EXACT []
synonym: "cysteine biosynthesis" EXACT []
synonym: "cysteine formation" EXACT []
synonym: "cysteine synthesis" EXACT []
is_a: GO:0000097 ! sulfur amino acid biosynthetic process
is_a: GO:0006534 ! cysteine metabolic process
is_a: GO:0009070 ! serine family amino acid biosynthetic process

[Term]
id: GO:0019345
name: cysteine biosynthetic process via S-sulfo-L-cysteine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate S-sulfo-L-cysteine." [GOC:go_curators]
subset: gosubset_prok
synonym: "cysteine anabolism via S-sulfo-L-cysteine" EXACT []
synonym: "cysteine biosynthesis via S-sulpho-L-cysteine" EXACT []
synonym: "cysteine biosynthetic process via S-sulpho-L-cysteine" EXACT []
synonym: "cysteine formation via S-sulfo-L-cysteine" EXACT []
synonym: "cysteine synthesis via S-sulfo-L-cysteine" EXACT []
is_a: GO:0019344 ! cysteine biosynthetic process

[Term]
id: GO:0019346
name: transsulfuration
namespace: biological_process
def: "The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes." [MetaCyc:PWY-801]
subset: gosubset_prok
synonym: "homocysteine-cysteine interconversion" NARROW []
synonym: "transsulphuration" EXACT []
xref: MetaCyc:PWY-801
xref: Wikipedia:Transsulfuration_pathway
is_a: GO:0006534 ! cysteine metabolic process
is_a: GO:0009092 ! homoserine metabolic process
is_a: GO:0050667 ! homocysteine metabolic process

[Term]
id: GO:0019347
name: GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol anabolism" EXACT []
synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthesis" EXACT []
synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol formation" EXACT []
synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol synthesis" EXACT []
xref: MetaCyc:MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0019408 ! dolichol biosynthetic process
is_a: GO:0046376 ! GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process

[Term]
id: GO:0019348
name: dolichol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dolichol metabolism" EXACT []
is_a: GO:0016093 ! polyprenol metabolic process

[Term]
id: GO:0019349
name: ribitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. It occurs free in some plants and is a component of riboflavin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ribitol metabolism" EXACT []
is_a: GO:0019321 ! pentose metabolic process
is_a: GO:0019519 ! pentitol metabolic process

[Term]
id: GO:0019350
name: teichoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "teichoic acid anabolism" EXACT []
synonym: "teichoic acid biosynthesis" EXACT []
synonym: "teichoic acid formation" EXACT []
synonym: "teichoic acid synthesis" EXACT []
xref: MetaCyc:TEICHOICACID-PWY
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0016053 ! organic acid biosynthetic process
is_a: GO:0044038 ! cell wall macromolecule biosynthetic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process
is_a: GO:0046374 ! teichoic acid metabolic process
relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis

[Term]
id: GO:0019351
name: dethiobiotin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dethiobiotin, a derivative of biotin in which the sulfur atom has been replaced by two hydrogen atoms." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "desthiobiotin biosynthesis" EXACT []
synonym: "desthiobiotin biosynthetic process" EXACT []
synonym: "dethiobiotin anabolism" EXACT []
synonym: "dethiobiotin biosynthesis" EXACT []
synonym: "dethiobiotin formation" EXACT []
synonym: "dethiobiotin synthesis" EXACT []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046450 ! dethiobiotin metabolic process
relationship: part_of GO:0009102 ! biotin biosynthetic process

[Term]
id: GO:0019352
name: protoporphyrinogen IX biosynthetic process from glycine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glycine." [GOC:go_curators]
subset: gosubset_prok
synonym: "protoporphyrinogen IX anabolism from glycine" EXACT []
synonym: "protoporphyrinogen IX formation from glycine" EXACT []
synonym: "protoporphyrinogen IX synthesis from glycine" EXACT []
is_a: GO:0006544 ! glycine metabolic process
is_a: GO:0006782 ! protoporphyrinogen IX biosynthetic process

[Term]
id: GO:0019353
name: protoporphyrinogen IX biosynthetic process from glutamate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate." [GOC:go_curators]
subset: gosubset_prok
synonym: "protoporphyrinogen IX anabolism from glutamate" EXACT []
synonym: "protoporphyrinogen IX formation from glutamate" EXACT []
synonym: "protoporphyrinogen IX synthesis from glutamate" EXACT []
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0006782 ! protoporphyrinogen IX biosynthetic process
is_a: GO:0033526 ! tetrapyrrole biosynthetic process from glutamate

[Term]
id: GO:0019354
name: siroheme biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sirohaem biosynthesis" EXACT []
synonym: "sirohaem biosynthetic process" EXACT []
synonym: "siroheme anabolism" EXACT []
synonym: "siroheme biosynthesis" EXACT []
synonym: "siroheme formation" EXACT []
synonym: "siroheme synthase activity" RELATED []
synonym: "siroheme synthesis" EXACT []
xref: AraCyc:PWYQT-62
xref: MetaCyc:PWY-5194
is_a: GO:0006783 ! heme biosynthetic process
is_a: GO:0046156 ! siroheme metabolic process

[Term]
id: GO:0019355
name: nicotinamide nucleotide biosynthetic process from aspartate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including aspartate." [GOC:go_curators]
subset: gosubset_prok
synonym: "nicotinamide nucleotide anabolism from aspartate" EXACT []
synonym: "nicotinamide nucleotide formation from aspartate" EXACT []
synonym: "nicotinamide nucleotide synthesis from aspartate" EXACT []
is_a: GO:0006531 ! aspartate metabolic process
is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process

[Term]
id: GO:0019356
name: nicotinate nucleotide biosynthetic process from tryptophan
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinate nucleotide from other compounds, including tryptophan." [GOC:go_curators]
subset: gosubset_prok
synonym: "nicotinate nucleotide anabolism from tryptophan" EXACT []
synonym: "nicotinate nucleotide formation from tryptophan" EXACT []
synonym: "nicotinate nucleotide synthesis from tryptophan" EXACT []
is_a: GO:0006568 ! tryptophan metabolic process
is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process

[Term]
id: GO:0019357
name: nicotinate nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid)." [GOC:go_curators]
subset: gosubset_prok
synonym: "nicotinate nucleotide anabolism" EXACT []
synonym: "nicotinate nucleotide biosynthesis" EXACT []
synonym: "nicotinate nucleotide formation" EXACT []
synonym: "nicotinate nucleotide synthesis" EXACT []
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0046497 ! nicotinate nucleotide metabolic process

[Term]
id: GO:0019358
name: nicotinate nucleotide salvage
namespace: biological_process
def: "The generation of nicotinate nucleotide without de novo synthesis." [GOC:go_curators]
subset: gosubset_prok
synonym: "nicotinate nucleotide biosynthesis, salvage pathway" EXACT []
synonym: "nicotinate nucleotide biosynthetic process, salvage pathway" EXACT []
xref: MetaCyc:PWY-5381
xref: MetaCyc:PYRIDNUCSAL-PWY
is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process
is_a: GO:0019365 ! pyridine nucleotide salvage

[Term]
id: GO:0019359
name: nicotinamide nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators]
subset: gosubset_prok
synonym: "nicotinamide nucleotide anabolism" EXACT []
synonym: "nicotinamide nucleotide biosynthesis" EXACT []
synonym: "nicotinamide nucleotide formation" EXACT []
synonym: "nicotinamide nucleotide synthesis" EXACT []
is_a: GO:0019363 ! pyridine nucleotide biosynthetic process
is_a: GO:0046496 ! nicotinamide nucleotide metabolic process

[Term]
id: GO:0019360
name: nicotinamide nucleotide biosynthetic process from niacinamide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including niacinamide." [GOC:go_curators]
subset: gosubset_prok
synonym: "nicotinamide nucleotide anabolism from niacinamide" EXACT []
synonym: "nicotinamide nucleotide formation from niacinamide" EXACT []
synonym: "nicotinamide nucleotide synthesis from niacinamide" EXACT []
is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process

[Term]
id: GO:0019361
name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai]
subset: gosubset_prok
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA anabolism" EXACT []
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthesis" EXACT []
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA formation" EXACT []
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA synthesis" EXACT []
xref: MetaCyc:P2-PWY
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0046432 ! 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process

[Term]
id: GO:0019362
name: pyridine nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl]
subset: gosubset_prok
synonym: "pyridine nucleotide metabolism" EXACT []
is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process
is_a: GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0019363
name: pyridine nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl]
subset: gosubset_prok
synonym: "pyridine nucleotide anabolism" EXACT []
synonym: "pyridine nucleotide biosynthesis" EXACT []
synonym: "pyridine nucleotide formation" EXACT []
synonym: "pyridine nucleotide synthesis" EXACT []
xref: MetaCyc:PYRIDNUCSYN-PWY
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0019362 ! pyridine nucleotide metabolic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process

[Term]
id: GO:0019364
name: pyridine nucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl]
subset: gosubset_prok
synonym: "pyridine nucleotide breakdown" EXACT []
synonym: "pyridine nucleotide catabolism" EXACT []
synonym: "pyridine nucleotide degradation" EXACT []
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0019362 ! pyridine nucleotide metabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0019365
name: pyridine nucleotide salvage
namespace: biological_process
def: "Any process that generates a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base, from derivatives of them without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "pyridine nucleotide cycling" EXACT []
is_a: GO:0019363 ! pyridine nucleotide biosynthetic process
is_a: GO:0043173 ! nucleotide salvage

[Term]
id: GO:0019367
name: fatty acid elongation, saturated fatty acid
namespace: biological_process
def: "Elongation of a saturated fatty acid chain." [GOC:mah]
subset: gosubset_prok
xref: MetaCyc:FASYN-ELONG-PWY
is_a: GO:0030497 ! fatty acid elongation

[Term]
id: GO:0019368
name: fatty acid elongation, unsaturated fatty acid
namespace: biological_process
def: "Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced." [GOC:mah]
subset: gosubset_prok
xref: MetaCyc:PWY0-862
is_a: GO:0030497 ! fatty acid elongation

[Term]
id: GO:0019369
name: arachidonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "arachidonic acid metabolism" EXACT []
xref: Wikipedia:Arachidonic_acid
is_a: GO:0000038 ! very-long-chain fatty acid metabolic process
is_a: GO:0006690 ! icosanoid metabolic process

[Term]
id: GO:0019370
name: leukotriene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "leukotriene anabolism" EXACT []
synonym: "leukotriene biosynthesis" EXACT []
synonym: "leukotriene formation" EXACT []
synonym: "leukotriene synthesis" EXACT []
xref: Reactome:265309 "Leukotriene synthesis"
xref: Reactome:448982 "Leukotriene synthesis"
xref: Reactome:470135 "Leukotriene synthesis"
xref: Reactome:487792 "Leukotriene synthesis"
xref: Reactome:507756 "Leukotriene synthesis"
xref: Reactome:517777 "Leukotriene synthesis"
xref: Reactome:526657 "Leukotriene synthesis"
xref: Reactome:531409 "Leukotriene synthesis"
xref: Reactome:536826 "Leukotriene synthesis"
xref: Reactome:542461 "Leukotriene synthesis"
xref: Reactome:547865 "Leukotriene synthesis"
xref: Reactome:552477 "Leukotriene synthesis"
xref: Reactome:558094 "Leukotriene synthesis"
xref: Reactome:568619 "Leukotriene synthesis"
xref: Reactome:581823 "Leukotriene synthesis"
xref: Reactome:585977 "Leukotriene synthesis"
xref: Reactome:592729 "Leukotriene synthesis"
xref: Reactome:597410 "Leukotriene synthesis"
xref: Wikipedia:Leukotriene#Leukotriene_synthesis
is_a: GO:0006691 ! leukotriene metabolic process
is_a: GO:0043450 ! alkene biosynthetic process
is_a: GO:0046456 ! icosanoid biosynthetic process

[Term]
id: GO:0019371
name: cyclooxygenase pathway
namespace: biological_process
def: "The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2." [PMID:19854273]
subset: gosubset_prok
is_a: GO:0019369 ! arachidonic acid metabolic process
relationship: part_of GO:0001516 ! prostaglandin biosynthetic process

[Term]
id: GO:0019372
name: lipoxygenase pathway
namespace: biological_process
def: "The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase." [GOC:mah, PMID:17163881]
subset: gosubset_prok
is_a: GO:0000038 ! very-long-chain fatty acid metabolic process
is_a: GO:0006690 ! icosanoid metabolic process

[Term]
id: GO:0019373
name: epoxygenase P450 pathway
namespace: biological_process
def: "The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids." [GOC:mah, PMID:17979511]
subset: gosubset_prok
is_a: GO:0019369 ! arachidonic acid metabolic process

[Term]
id: GO:0019374
name: galactolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "galactolipid metabolism" EXACT []
is_a: GO:0006664 ! glycolipid metabolic process

[Term]
id: GO:0019375
name: galactolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "galactolipid anabolism" EXACT []
synonym: "galactolipid biosynthesis" EXACT []
synonym: "galactolipid formation" EXACT []
synonym: "galactolipid synthesis" EXACT []
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0019374 ! galactolipid metabolic process

[Term]
id: GO:0019376
name: galactolipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "galactolipid breakdown" EXACT []
synonym: "galactolipid catabolism" EXACT []
synonym: "galactolipid degradation" EXACT []
is_a: GO:0019374 ! galactolipid metabolic process
is_a: GO:0019377 ! glycolipid catabolic process

[Term]
id: GO:0019377
name: glycolipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycolipid, a compound containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycolipid breakdown" EXACT []
synonym: "glycolipid catabolism" EXACT []
synonym: "glycolipid degradation" EXACT []
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0046466 ! membrane lipid catabolic process

[Term]
id: GO:0019379
name: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
namespace: biological_process
def: "The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8)." [GOC:jl]
subset: gosubset_prok
synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by a phosphoadenylyl-sulphate reductase (thioredoxin)" EXACT []
xref: MetaCyc:SO4ASSIM-PWY
is_a: GO:0000103 ! sulfate assimilation
is_a: GO:0019419 ! sulfate reduction

[Term]
id: GO:0019380
name: 3-phenylpropionate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "3-phenylpropionate breakdown" EXACT []
synonym: "3-phenylpropionate catabolism" EXACT []
synonym: "3-phenylpropionate degradation" EXACT []
xref: MetaCyc:HCAMHPDEG-PWY
xref: MetaCyc:P281-PWY
is_a: GO:0018962 ! 3-phenylpropionate metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0019381
name: atrazine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide." [GOC:jl, http://umbbd.ahc.umn.edu/atr/atr_map.html, UM-BBD_pathwayID:atr]
subset: gosubset_prok
synonym: "atrazine breakdown" EXACT []
synonym: "atrazine catabolism" EXACT []
synonym: "atrazine degradation" EXACT []
xref: MetaCyc:P141-PWY
is_a: GO:0018873 ! atrazine metabolic process
is_a: GO:0042204 ! s-triazine compound catabolic process

[Term]
id: GO:0019382
name: carbon tetrachloride catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [GOC:go_curators]
subset: gosubset_prok
synonym: "carbon tetrachloride breakdown" EXACT []
synonym: "carbon tetrachloride catabolism" EXACT []
synonym: "carbon tetrachloride degradation" EXACT []
is_a: GO:0018885 ! carbon tetrachloride metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process

[Term]
id: GO:0019383
name: (+)-camphor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone." [http://umbbd.ahc.umn.edu/cam/cam_map.html, UM-BBD_pathwayID:cam]
subset: gosubset_prok
synonym: "(+)-camphor breakdown" EXACT []
synonym: "(+)-camphor catabolism" EXACT []
synonym: "(+)-camphor degradation" EXACT []
xref: MetaCyc:P601-PWY
is_a: GO:0018882 ! (+)-camphor metabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0043694 ! monoterpene catabolic process

[Term]
id: GO:0019384
name: caprolactam catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "caprolactam breakdown" EXACT []
synonym: "caprolactam catabolism" EXACT []
synonym: "caprolactam degradation" EXACT []
xref: MetaCyc:P621-PWY
is_a: GO:0018883 ! caprolactam metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043605 ! cellular amide catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0019385
name: methanogenesis, from acetate
namespace: biological_process
def: "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including acetate." [GOC:ai]
subset: gosubset_prok
synonym: "methane biosynthesis from acetate" EXACT []
synonym: "methane biosynthetic process from acetate" EXACT []
xref: MetaCyc:METH-ACETATE-PWY
is_a: GO:0015948 ! methanogenesis

[Term]
id: GO:0019386
name: methanogenesis, from carbon dioxide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other compounds, including carbon dioxide (CO2)." [GOC:ai]
subset: gosubset_prok
synonym: "methane biosynthesis from carbon dioxide" EXACT []
synonym: "methane biosynthetic process from carbon dioxide" EXACT []
xref: MetaCyc:METHANOGENESIS-PWY
is_a: GO:0015948 ! methanogenesis

[Term]
id: GO:0019387
name: methanogenesis, from methanol
namespace: biological_process
def: "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including methanol." [GOC:ai]
subset: gosubset_prok
synonym: "methane biosynthesis from methanol" EXACT []
synonym: "methane biosynthetic process from methanol" EXACT []
xref: MetaCyc:METHFORM-PWY
is_a: GO:0015948 ! methanogenesis

[Term]
id: GO:0019388
name: galactose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "galactose breakdown" EXACT []
synonym: "galactose catabolism" EXACT []
synonym: "galactose degradation" EXACT []
xref: MetaCyc:GALDEG-PWY
xref: Reactome:448873 "Galactose catabolism"
xref: Reactome:469990 "Galactose catabolism"
xref: Reactome:487695 "Galactose catabolism"
xref: Reactome:507647 "Galactose catabolism"
xref: Reactome:517610 "Galactose catabolism"
xref: Reactome:526458 "Galactose catabolism"
xref: Reactome:531262 "Galactose catabolism"
xref: Reactome:536641 "Galactose catabolism"
xref: Reactome:542369 "Galactose catabolism"
xref: Reactome:547714 "Galactose catabolism"
xref: Reactome:552293 "Galactose catabolism"
xref: Reactome:557915 "Galactose catabolism"
xref: Reactome:568527 "Galactose catabolism"
xref: Reactome:581739 "Galactose catabolism"
xref: Reactome:585863 "Galactose catabolism"
xref: Reactome:592638 "Galactose catabolism"
xref: Reactome:599721 "Galactose catabolism"
xref: Reactome:600708 "Galactose catabolism"
xref: Reactome:602525 "Galactose catabolism"
xref: Reactome:70370 "Galactose catabolism"
is_a: GO:0006012 ! galactose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0019389
name: glucuronoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucuronosides, any compound formed by combination in glycosidic linkage of a hydroxy compound with the anomeric carbon atom of a glucuronate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glucuronide metabolic process" EXACT []
synonym: "glucuronide metabolism" EXACT []
synonym: "glucuronoside metabolism" EXACT []
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0019390
name: glucuronoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glucuronide biosynthesis" EXACT []
synonym: "glucuronide biosynthetic process" EXACT []
synonym: "glucuronoside anabolism" EXACT []
synonym: "glucuronoside biosynthesis" EXACT []
synonym: "glucuronoside formation" EXACT []
synonym: "glucuronoside synthesis" EXACT []
is_a: GO:0019389 ! glucuronoside metabolic process
is_a: GO:0034637 ! cellular carbohydrate biosynthetic process

[Term]
id: GO:0019391
name: glucuronoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glucuronide catabolic process" EXACT []
synonym: "glucuronide catabolism" EXACT []
synonym: "glucuronoside breakdown" EXACT []
synonym: "glucuronoside catabolism" EXACT []
synonym: "glucuronoside degradation" EXACT []
xref: MetaCyc:GLUCUROCAT-PWY
is_a: GO:0019389 ! glucuronoside metabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process

[Term]
id: GO:0019392
name: glucarate metabolic process
namespace: biological_process
alt_id: GO:0019581
def: "The chemical reactions and pathways involving glucarate, the dianion of glucaric acid, an aldaric acid derived from either glucose or gulose. There are two enantiomers L- and D-glucarate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glucarate metabolism" EXACT []
is_a: GO:0019577 ! aldaric acid metabolic process

[Term]
id: GO:0019393
name: glucarate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glucarate anabolism" EXACT []
synonym: "glucarate biosynthesis" EXACT []
synonym: "glucarate formation" EXACT []
synonym: "glucarate synthesis" EXACT []
is_a: GO:0019392 ! glucarate metabolic process
is_a: GO:0019578 ! aldaric acid biosynthetic process

[Term]
id: GO:0019394
name: glucarate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glucarate breakdown" EXACT []
synonym: "glucarate catabolism" EXACT []
synonym: "glucarate degradation" EXACT []
xref: MetaCyc:GLUCARDEG-PWY
is_a: GO:0019392 ! glucarate metabolic process
is_a: GO:0019579 ! aldaric acid catabolic process

[Term]
id: GO:0019395
name: fatty acid oxidation
namespace: biological_process
def: "The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:FAO-PWY]
subset: gosubset_prok
xref: MetaCyc:FAO-PWY
is_a: GO:0006631 ! fatty acid metabolic process
is_a: GO:0034440 ! lipid oxidation

[Term]
id: GO:0019396
name: gallate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid)." [GOC:jl]
subset: gosubset_prok
synonym: "gallate breakdown" EXACT []
synonym: "gallate catabolism" EXACT []
synonym: "gallate degradation" EXACT []
synonym: "gallic acid catabolic process" EXACT []
synonym: "gallic acid catabolism" EXACT []
is_a: GO:0018918 ! gallate metabolic process
is_a: GO:0019614 ! catechol catabolic process

[Term]
id: GO:0019397
name: gallate catabolic process via 2-pyrone-4,6-dicarboxylate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 2-pyrone-4,6-dicarboxylate." [GOC:jl]
subset: gosubset_prok
synonym: "gallate breakdown via 2-pyrone-4,6-dicarboxylate" EXACT []
synonym: "gallate degradation via 2-pyrone-4,6-dicarboxylate" EXACT []
synonym: "gallic acid catabolic process via 2-pyrone-4,6-dicarboxylate" EXACT []
synonym: "gallic acid catabolism via 2-pyrone-4,6-dicarboxylate" EXACT []
xref: MetaCyc:GALLATE-DEGRADATION-I-PWY
is_a: GO:0042195 ! aerobic gallate catabolic process

[Term]
id: GO:0019398
name: gallate catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 4-carboxy-2-hydroxhexa-2,3-dienedioate." [GOC:jl]
subset: gosubset_prok
synonym: "gallate breakdown via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT []
synonym: "gallate degradation via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT []
synonym: "gallic acid catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT []
synonym: "gallic acid catabolism via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT []
xref: MetaCyc:GALLATE-DEGRADATION-II-PWY
is_a: GO:0042195 ! aerobic gallate catabolic process

[Term]
id: GO:0019399
name: cyclohexanol oxidation
namespace: biological_process
def: "The cyclohexanol metabolic process by which cyclohexanol is converted to adipate." [MetaCyc:CYCLOHEXANOL-OXIDATION-PWY]
subset: gosubset_prok
xref: MetaCyc:CYCLOHEXANOL-OXIDATION-PWY
is_a: GO:0018891 ! cyclohexanol metabolic process

[Term]
id: GO:0019400
name: alditol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "alditol metabolism" EXACT []
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0019401
name: alditol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "alditol anabolism" EXACT []
synonym: "alditol biosynthesis" EXACT []
synonym: "alditol formation" EXACT []
synonym: "alditol synthesis" EXACT []
is_a: GO:0019400 ! alditol metabolic process
is_a: GO:0034637 ! cellular carbohydrate biosynthetic process
is_a: GO:0046173 ! polyol biosynthetic process

[Term]
id: GO:0019402
name: galactitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "galactitol metabolism" EXACT []
is_a: GO:0006059 ! hexitol metabolic process

[Term]
id: GO:0019403
name: galactitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "galactitol anabolism" EXACT []
synonym: "galactitol biosynthesis" EXACT []
synonym: "galactitol formation" EXACT []
synonym: "galactitol synthesis" EXACT []
is_a: GO:0019402 ! galactitol metabolic process
is_a: GO:0019406 ! hexitol biosynthetic process

[Term]
id: GO:0019404
name: galactitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "galactitol breakdown" EXACT []
synonym: "galactitol catabolism" EXACT []
synonym: "galactitol degradation" EXACT []
xref: MetaCyc:GALACTITOLCAT-PWY
is_a: GO:0019402 ! galactitol metabolic process
is_a: GO:0019407 ! hexitol catabolic process

[Term]
id: GO:0019405
name: alditol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "alditol breakdown" EXACT []
synonym: "alditol catabolism" EXACT []
synonym: "alditol degradation" EXACT []
is_a: GO:0019400 ! alditol metabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process
is_a: GO:0046174 ! polyol catabolic process

[Term]
id: GO:0019406
name: hexitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "hexitol anabolism" EXACT []
synonym: "hexitol biosynthesis" EXACT []
synonym: "hexitol formation" EXACT []
synonym: "hexitol synthesis" EXACT []
is_a: GO:0006059 ! hexitol metabolic process
is_a: GO:0019401 ! alditol biosynthetic process

[Term]
id: GO:0019407
name: hexitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "hexitol breakdown" EXACT []
synonym: "hexitol catabolism" EXACT []
synonym: "hexitol degradation" EXACT []
is_a: GO:0006059 ! hexitol metabolic process
is_a: GO:0019405 ! alditol catabolic process

[Term]
id: GO:0019408
name: dolichol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dolichol anabolism" EXACT []
synonym: "dolichol biosynthesis" EXACT []
synonym: "dolichol formation" EXACT []
synonym: "dolichol synthesis" EXACT []
is_a: GO:0016094 ! polyprenol biosynthetic process
is_a: GO:0019348 ! dolichol metabolic process

[Term]
id: GO:0019409
name: aerobic respiration, using ammonia as electron donor
namespace: biological_process
def: "The metabolic process by which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen; enzymatic reactions convert ammonia to hydrazine, and hydrazine to nitrite." [MetaCyc:AMMOXID-PWY]
subset: gosubset_prok
synonym: "aerobic ammonia oxidation to nitrite via hydrazine" EXACT [GOC:mah]
xref: MetaCyc:AMMOXID-PWY
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds
is_a: GO:0019329 ! ammonia oxidation
is_a: GO:0034641 ! cellular nitrogen compound metabolic process

[Term]
id: GO:0019410
name: aerobic respiration, using carbon monoxide as electron donor
namespace: biological_process
def: "The metabolic process by which carbon monoxide (CO) is oxidized to carbon dioxide (CO2) to generate energy. Conservation of energy in this process likely uses sodium ion gradients for ATP synthesis and is coupled to quantitative sulfide methylation." [PMID:18024677]
subset: gosubset_prok
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0019411
name: aerobic respiration, using ferrous ions as electron donor
namespace: biological_process
def: "The metabolic process by which ferrous ions (Fe2+) are oxidized to ferric ions (Fe3+) to generate energy, coupled to the reduction of carbon dioxide." [ISBN:3131084111]
subset: gosubset_prok
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0019412
name: aerobic respiration, using hydrogen as electron donor
namespace: biological_process
def: "The oxidation of hydrogen (H2) to water (H2O), using oxygen (O2) as the electron acceptor. A hydrogenase enzyme binds H2 and the hydrogen atoms are passed through an electron transfer chain to O2 to form water." [MetaCyc:P283-PWY]
subset: gosubset_prok
synonym: "hydrogen oxidation" BROAD []
xref: MetaCyc:P283-PWY
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0019413
name: acetate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "acetate anabolism" EXACT []
synonym: "acetate biosynthesis" EXACT []
synonym: "acetate formation" EXACT []
synonym: "acetate synthesis" EXACT []
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0019414
name: aerobic respiration, using sulfur or sulfate as electron donor
namespace: biological_process
subset: gosubset_prok
synonym: "aerobic respiration, using sulphur or sulphate as electron donor" EXACT []
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0019415
name: acetate biosynthetic process from carbon monoxide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetate from other compounds, including carbon monoxide." [GOC:go_curators]
subset: gosubset_prok
synonym: "acetate anabolism from carbon monoxide" EXACT []
synonym: "acetate formation from carbon monoxide" EXACT []
synonym: "acetate synthesis from carbon monoxide" EXACT []
synonym: "carbon monoxide dehydrogenase pathway" EXACT []
xref: MetaCyc:CODH-PWY
is_a: GO:0019413 ! acetate biosynthetic process

[Term]
id: GO:0019416
name: polythionate oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of thiosulfate to tetrathionate, using cytochrome c as an electron acceptor." [MetaCyc:THIOSULFOX-PWY]
subset: gosubset_prok
xref: MetaCyc:THIOSULFOX-PWY
is_a: GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0019417
name: sulfur oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur." [GOC:jl, MetaCyc:FESULFOX-PWY, MetaCyc:SULFUROX-PWY]
subset: gosubset_prok
synonym: "sulphur oxidation" EXACT []
is_a: GO:0006791 ! sulfur utilization

[Term]
id: GO:0019418
name: sulfide oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate." [MetaCyc:P222-PWY, MetaCyc:P223-PWY, MetaCyc:PWY-5274, MetaCyc:PWY-5285]
subset: gosubset_prok
synonym: "sulphide oxidation" EXACT []
xref: MetaCyc:P222-PWY
is_a: GO:0006791 ! sulfur utilization

[Term]
id: GO:0019419
name: sulfate reduction
namespace: biological_process
alt_id: GO:0019421
def: "The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate." [MetaCyc:DISSULFRED-PWY, MetaCyc:P224-PWY, MetaCyc:SO4ASSIM-PWY, MetaCyc:SULFMETII-PWY]
subset: gosubset_prok
synonym: "assimilatory sulfate reduction" NARROW []
synonym: "assimilatory sulphate reduction" NARROW []
synonym: "sulfate reduction, APS pathway" NARROW []
synonym: "sulphate reduction" EXACT []
synonym: "sulphate reduction, APS pathway" NARROW []
is_a: GO:0006791 ! sulfur utilization

[Term]
id: GO:0019420
name: dissimilatory sulfate reduction
namespace: biological_process
def: "The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide." [GOC:jl, MetaCyc:DISSULFRED-PWY]
subset: gosubset_prok
synonym: "dissimilatory sulphate reduction" EXACT []
xref: MetaCyc:DISSULFRED-PWY
is_a: GO:0019419 ! sulfate reduction

[Term]
id: GO:0019422
name: disproportionation of elemental sulfur
namespace: biological_process
def: "The process by which sulfur compounds with an intermediate oxidation state serve as both electron donors and electron acceptors in an energy-generating redox process. The reaction takes place anaerobically, in light and in the absence of CO2." [MetaCyc:P203-PWY]
subset: gosubset_prok
synonym: "disproportionation of elemental sulphur" EXACT []
xref: MetaCyc:P203-PWY
is_a: GO:0006791 ! sulfur utilization

[Term]
id: GO:0019423
name: sulfur oxidation, ferric ion-dependent
namespace: biological_process
def: "A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur:ferric ion oxidoreductase, and requires the presence of ferric ion (Fe3+)." [MetaCyc:FESULFOX-PWY]
subset: gosubset_prok
synonym: "sulphur oxidation, ferric ion-dependent" EXACT []
xref: MetaCyc:FESULFOX-PWY
is_a: GO:0019417 ! sulfur oxidation

[Term]
id: GO:0019424
name: sulfide oxidation, using siroheme sulfite reductase
namespace: biological_process
alt_id: GO:0019425
def: "A sulfide oxidation process that proceeds via the reaction catalyzed by siroheme sulfite reductase." [MetaCyc:P223-PWY]
subset: gosubset_prok
synonym: "sulfide oxidation, using sirohaem sulfite reductase" EXACT []
synonym: "sulfur oxidation, using sirohaem sulfite reductase" RELATED []
synonym: "sulfur oxidation, using siroheme sulfite reductase" RELATED []
synonym: "sulphide oxidation, using siroheme sulphite reductase" EXACT []
synonym: "sulphur oxidation, using siroheme sulphite reductase" RELATED []
xref: MetaCyc:P223-PWY
is_a: GO:0019418 ! sulfide oxidation

[Term]
id: GO:0019426
name: bisulfite reduction
namespace: biological_process
def: "The chemical reactions and pathways resulting in the reduction of sulfate to thiosulfate via bisulfite." [MetaCyc:P224-PWY]
subset: gosubset_prok
synonym: "bisulphite reduction" EXACT []
xref: MetaCyc:P224-PWY
is_a: GO:0019419 ! sulfate reduction

[Term]
id: GO:0019427
name: acetyl-CoA biosynthetic process from acetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate." [MetaCyc:ACETATEUTIL-PWY]
subset: gosubset_prok
synonym: "acetate utilization" RELATED []
synonym: "acetyl-CoA anabolism from acetate" EXACT []
synonym: "acetyl-CoA formation from acetate" EXACT []
synonym: "acetyl-CoA synthesis from acetate" EXACT []
xref: MetaCyc:ACETATEUTIL-PWY
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0006085 ! acetyl-CoA biosynthetic process

[Term]
id: GO:0019428
name: allantoin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:go_curators]
subset: gosubset_prok
synonym: "allantoin anabolism" EXACT []
synonym: "allantoin biosynthesis" EXACT []
synonym: "allantoin formation" EXACT []
synonym: "allantoin synthesis" EXACT []
xref: MetaCyc:URSIN-PWY
is_a: GO:0000255 ! allantoin metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0019429
name: fluorene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [GOC:go_curators]
subset: gosubset_prok
synonym: "fluorene breakdown" EXACT []
synonym: "fluorene catabolism" EXACT []
synonym: "fluorene degradation" EXACT []
xref: MetaCyc:FLUORENE-DEG-9-ONE-PWY
is_a: GO:0018917 ! fluorene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043451 ! alkene catabolic process

[Term]
id: GO:0019430
name: removal of superoxide radicals
namespace: biological_process
def: "Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2)." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "removal of O2-" EXACT []
synonym: "removal of oxygen free radicals" EXACT []
xref: MetaCyc:DETOX1-PWY
is_a: GO:0006801 ! superoxide metabolic process
is_a: GO:0071451 ! cellular response to superoxide

[Term]
id: GO:0019431
name: acetyl-CoA biosynthetic process from ethanol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from ethanol via acetaldehyde." [GOC:go_curators]
subset: gosubset_prok
synonym: "acetyl-CoA anabolism from ethanol" EXACT []
synonym: "acetyl-CoA formation from ethanol" EXACT []
synonym: "acetyl-CoA synthesis from ethanol" EXACT []
xref: MetaCyc:ETOH-ACETYLCOA-ANA-PWY
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0006085 ! acetyl-CoA biosynthetic process

[Term]
id: GO:0019432
name: triglyceride biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "triacylglycerol biosynthesis" EXACT []
synonym: "triacylglycerol biosynthetic process" EXACT []
synonym: "triglyceride anabolism" EXACT []
synonym: "triglyceride biosynthesis" EXACT []
synonym: "triglyceride formation" EXACT []
synonym: "triglyceride synthesis" EXACT []
xref: MetaCyc:TRIGLSYN-PWY
is_a: GO:0006641 ! triglyceride metabolic process
is_a: GO:0046463 ! acylglycerol biosynthetic process

[Term]
id: GO:0019433
name: triglyceride catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "triacylglycerol catabolic process" EXACT []
synonym: "triacylglycerol catabolism" EXACT []
synonym: "triglyceride breakdown" EXACT []
synonym: "triglyceride catabolism" EXACT []
synonym: "triglyceride degradation" EXACT []
xref: MetaCyc:LIPAS-PWY
xref: Reactome:163560 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:448516 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:469646 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:487358 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:507309 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:517324 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:526206 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:531092 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:536492 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:542169 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:547529 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:552120 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:557711 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:568327 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:581529 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:585773 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:592416 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:597273 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:599615 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
xref: Reactome:602418 "Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis"
is_a: GO:0006641 ! triglyceride metabolic process
is_a: GO:0046464 ! acylglycerol catabolic process

[Term]
id: GO:0019434
name: sophorosyloxydocosanoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon." [MetaCyc:DIGLUCODIACETYL-DOCOSANOATE]
subset: gosubset_prok
synonym: "sophorosyloxydocosanoate metabolism" EXACT []
is_a: GO:0006664 ! glycolipid metabolic process
is_a: GO:0006725 ! cellular aromatic compound metabolic process

[Term]
id: GO:0019435
name: sophorosyloxydocosanoate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate." [GOC:ai]
subset: gosubset_prok
synonym: "sophorosyloxydocosanoate anabolism" EXACT []
synonym: "sophorosyloxydocosanoate biosynthesis" EXACT []
synonym: "sophorosyloxydocosanoate formation" EXACT []
synonym: "sophorosyloxydocosanoate synthesis" EXACT []
xref: MetaCyc:SOPHOROSYLOXYDOCOSANOATE-SYN-PWY
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0019434 ! sophorosyloxydocosanoate metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process

[Term]
id: GO:0019436
name: sophorosyloxydocosanoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate." [GOC:ai]
subset: gosubset_prok
synonym: "sophorosyloxydocosanoate breakdown" EXACT []
synonym: "sophorosyloxydocosanoate catabolism" EXACT []
synonym: "sophorosyloxydocosanoate degradation" EXACT []
xref: MetaCyc:SOPHOROSYLOXYDOCOSANOATE-DEG-PWY
is_a: GO:0019377 ! glycolipid catabolic process
is_a: GO:0019434 ! sophorosyloxydocosanoate metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process

[Term]
id: GO:0019438
name: aromatic compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]
subset: gosubset_prok
synonym: "aromatic compound anabolism" EXACT []
synonym: "aromatic compound biosynthesis" EXACT []
synonym: "aromatic compound formation" EXACT []
synonym: "aromatic compound synthesis" EXACT []
synonym: "aromatic hydrocarbon biosynthesis" NARROW []
synonym: "aromatic hydrocarbon biosynthetic process" NARROW []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0019439
name: aromatic compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai]
subset: gosubset_prok
synonym: "aromatic compound breakdown" EXACT []
synonym: "aromatic compound catabolism" EXACT []
synonym: "aromatic compound degradation" EXACT []
synonym: "aromatic hydrocarbon catabolic process" NARROW []
synonym: "aromatic hydrocarbon catabolism" NARROW []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0019440
name: tryptophan catabolic process to indole-3-acetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including indole-3-acetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "tryptophan breakdown to indole-3-acetate" EXACT []
synonym: "tryptophan catabolic process to IAA" EXACT []
synonym: "tryptophan catabolic process to indoleacetic acid" EXACT []
synonym: "tryptophan catabolism to indoleacetic acid" EXACT []
synonym: "tryptophan degradation to indole-3-acetate" EXACT []
xref: MetaCyc:TRPIAACAT-PWY
is_a: GO:0006569 ! tryptophan catabolic process
is_a: GO:0009683 ! indoleacetic acid metabolic process

[Term]
id: GO:0019441
name: tryptophan catabolic process to kynurenine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators]
subset: gosubset_prok
synonym: "tryptophan breakdown to kynurenine" EXACT []
synonym: "tryptophan degradation to kynurenine" EXACT []
xref: MetaCyc:TRPKYNCAT-PWY
is_a: GO:0006569 ! tryptophan catabolic process

[Term]
id: GO:0019442
name: tryptophan catabolic process to acetyl-CoA
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA." [GOC:go_curators]
subset: gosubset_prok
synonym: "tryptophan breakdown to acetyl-CoA" EXACT []
synonym: "tryptophan degradation to acetyl-CoA" EXACT []
xref: MetaCyc:TRYPTOPHAN-DEGRADATION-1
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0006569 ! tryptophan catabolic process

[Term]
id: GO:0019443
name: tryptophan catabolic process, using tryptophanase
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tryptophan, catalyzed by the enzyme tryptophanase (EC:4.1.99.1)." [GOC:jl]
comment: This term was made obsolete because it refers to a one-step pathway.
synonym: "tryptophan breakdown, using tryptophanase" EXACT []
synonym: "tryptophan degradation, using tryptophanase" EXACT []
is_obsolete: true
replaced_by: GO:0006569
replaced_by: GO:0009034

[Term]
id: GO:0019444
name: tryptophan catabolic process to catechol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including catechol." [GOC:go_curators]
subset: gosubset_prok
synonym: "tryptophan breakdown to catechol" EXACT []
synonym: "tryptophan degradation to catechol" EXACT []
xref: MetaCyc:TRPCAT-PWY
is_a: GO:0006569 ! tryptophan catabolic process
is_a: GO:0009712 ! catechol metabolic process

[Term]
id: GO:0019445
name: tyrosine catabolic process to fumarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including fumarate." [GOC:go_curators]
subset: gosubset_prok
synonym: "tyrosine breakdown to fumarate" EXACT []
synonym: "tyrosine degradation to fumarate" EXACT []
xref: MetaCyc:TYRFUMCAT-PWY
is_a: GO:0006106 ! fumarate metabolic process
is_a: GO:0006572 ! tyrosine catabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0019446
name: tyrosine catabolic process to phosphoenolpyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including phosphoenolpyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "tyrosine breakdown to phosphoenolpyruvate" EXACT []
synonym: "tyrosine degradation to phosphoenolpyruvate" EXACT []
is_a: GO:0006572 ! tyrosine catabolic process

[Term]
id: GO:0019447
name: D-cysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-cysteine breakdown" EXACT []
synonym: "D-cysteine catabolism" EXACT []
synonym: "D-cysteine degradation" EXACT []
is_a: GO:0009093 ! cysteine catabolic process
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:0046438 ! D-cysteine metabolic process

[Term]
id: GO:0019448
name: L-cysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid." [ChEBI:17561, GOC:go_curators, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-cysteine breakdown" EXACT []
synonym: "L-cysteine catabolism" EXACT []
synonym: "L-cysteine degradation" EXACT []
is_a: GO:0009093 ! cysteine catabolic process
is_a: GO:0046439 ! L-cysteine metabolic process

[Term]
id: GO:0019449
name: L-cysteine catabolic process to hypotaurine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-cysteine breakdown to hypotaurine" EXACT []
synonym: "L-cysteine degradation to hypotaurine" EXACT []
is_a: GO:0019448 ! L-cysteine catabolic process

[Term]
id: GO:0019450
name: L-cysteine catabolic process to pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-cysteine breakdown to pyruvate" EXACT []
synonym: "L-cysteine degradation to pyruvate" EXACT []
xref: MetaCyc:LCYSDEG-PWY
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0019448 ! L-cysteine catabolic process

[Term]
id: GO:0019451
name: L-cysteine catabolic process to pyruvate, using cysteine dioxygenase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown into pyruvate of L-cystine, catalyzed by the enzyme cysteine dioxygenase (EC:1.13.11.20)." [GOC:jl]
subset: gosubset_prok
synonym: "L-cysteine breakdown to pyruvate, using cysteine dioxygenase" EXACT []
synonym: "L-cysteine degradation to pyruvate, using cysteine dioxygenase" EXACT []
xref: MetaCyc:CYSTEINE-DEG-PWY
is_a: GO:0019450 ! L-cysteine catabolic process to pyruvate

[Term]
id: GO:0019452
name: L-cysteine catabolic process to taurine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-cysteine breakdown to taurine" EXACT []
synonym: "L-cysteine degradation to taurine" EXACT []
is_a: GO:0019448 ! L-cysteine catabolic process
is_a: GO:0019530 ! taurine metabolic process

[Term]
id: GO:0019453
name: L-cysteine catabolic process via cystine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine, via the intermediate cystine." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-cysteine breakdown via cystine" EXACT []
synonym: "L-cysteine degradation via cystine" EXACT []
is_a: GO:0019448 ! L-cysteine catabolic process

[Term]
id: GO:0019454
name: L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme glutathione-cystine transhydrogenase (EC:1.8.4.4)." [GOC:jl]
subset: gosubset_prok
synonym: "L-cysteine breakdown via cystine, using glutathione-cystine transhydrogenase" EXACT []
synonym: "L-cysteine degradation via cystine, using glutathione-cystine transhydrogenase" EXACT []
is_a: GO:0019453 ! L-cysteine catabolic process via cystine

[Term]
id: GO:0019455
name: L-cysteine catabolic process via cystine, using cystine reductase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cystine reductase (EC:1.8.1.6)." [GOC:jl]
subset: gosubset_prok
synonym: "L-cysteine breakdown via cystine, using cystine reductase" EXACT []
synonym: "L-cysteine degradation via cystine, using cystine reductase" EXACT []
is_a: GO:0019453 ! L-cysteine catabolic process via cystine

[Term]
id: GO:0019456
name: L-cysteine catabolic process via cystine, using cysteine transaminase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cysteine transaminase (EC:2.6.1.3)." [GOC:jl]
subset: gosubset_prok
synonym: "L-cysteine breakdown via cystine, using cysteine transaminase" EXACT []
synonym: "L-cysteine degradation via cystine, using cysteine transaminase" EXACT []
is_a: GO:0019453 ! L-cysteine catabolic process via cystine

[Term]
id: GO:0019457
name: methionine catabolic process to succinyl-CoA
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methionine into other compounds, including succinyl-CoA." [GOC:go_curators]
subset: gosubset_prok
synonym: "methionine breakdown to succinyl-CoA" EXACT []
synonym: "methionine degradation to succinyl-CoA" EXACT []
xref: MetaCyc:METHIONINE-DEG1-PWY
is_a: GO:0006104 ! succinyl-CoA metabolic process
is_a: GO:0009087 ! methionine catabolic process

[Term]
id: GO:0019458
name: methionine catabolic process via 2-oxobutanoate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methionine, via the intermediate 2-oxobutanoate." [GOC:go_curators]
subset: gosubset_prok
synonym: "methionine breakdown via 2-oxobutanoate" EXACT []
synonym: "methionine degradation via 2-oxobutanoate" EXACT []
xref: MetaCyc:PWY-701
is_a: GO:0009087 ! methionine catabolic process

[Term]
id: GO:0019459
name: glutamate deamidation
namespace: biological_process
subset: gosubset_prok
xref: MetaCyc:GLUTAMINDEG-PWY
is_a: GO:0006538 ! glutamate catabolic process

[Term]
id: GO:0019460
name: glutamate catabolic process to fumarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including fumarate." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate breakdown to fumarate" EXACT []
synonym: "glutamate degradation to fumarate" EXACT []
is_a: GO:0006106 ! fumarate metabolic process
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0019461
name: glutamate catabolic process to fumarate, using glutamate synthase (NADPH)
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown into fumarate of glutamate, catalyzed by the enzyme glutamate synthase (NADPH) (EC:1.4.1.13)." [GOC:jl]
subset: gosubset_prok
synonym: "glutamate breakdown to fumarate, using glutamate synthase (NADPH)" EXACT []
synonym: "glutamate degradation to fumarate, using glutamate synthase (NADPH)" EXACT []
xref: MetaCyc:GLUTAMINEFUM-PWY
is_a: GO:0019460 ! glutamate catabolic process to fumarate

[Term]
id: GO:0019462
name: glutamate catabolic process to fumarate, using glutaminase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown into fumarate of glutamate, catalyzed by the enzyme glutaminase (EC:3.5.1.2)." [GOC:jl]
subset: gosubset_prok
synonym: "glutamate breakdown to fumarate, using glutaminase" EXACT []
synonym: "glutamate degradation to fumarate, using glutaminase" EXACT []
is_a: GO:0019460 ! glutamate catabolic process to fumarate

[Term]
id: GO:0019463
name: glycine catabolic process to creatine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycine into other compounds, including creatine." [GOC:go_curators]
subset: gosubset_prok
synonym: "glycine breakdown to creatine" EXACT []
synonym: "glycine degradation to creatine" EXACT []
xref: MetaCyc:GLYCGREAT-PWY
is_a: GO:0006546 ! glycine catabolic process
is_a: GO:0006600 ! creatine metabolic process

[Term]
id: GO:0019464
name: glycine decarboxylation via glycine cleavage system
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex." [MetaCyc:GLYCLEAV-PWY]
subset: gosubset_prok
synonym: "glycine cleavage system" BROAD []
xref: MetaCyc:GLYCLEAV-PWY
is_a: GO:0006546 ! glycine catabolic process

[Term]
id: GO:0019465
name: aspartate transamidation
namespace: biological_process
def: "The exchange of the amino group of aspartate, the anion derived from aspartic acid, for another amino group." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: MetaCyc:ASPARTATE-DEG1-PWY
xref: MetaCyc:ASPARTATESYN-PWY
is_a: GO:0006533 ! aspartate catabolic process

[Term]
id: GO:0019466
name: ornithine catabolic process via proline
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ornithine, via the intermediate proline." [GOC:go_curators]
subset: gosubset_prok
synonym: "ornithine breakdown via proline" EXACT []
synonym: "ornithine degradation via proline" EXACT []
xref: MetaCyc:ORN-AMINOPENTANOATE-CAT-PWY
is_a: GO:0006560 ! proline metabolic process
is_a: GO:0006593 ! ornithine catabolic process

[Term]
id: GO:0019467
name: ornithine catabolic process, by decarboxylation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ornithine by decarboxylation." [GOC:go_curators]
subset: gosubset_prok
synonym: "ornithine breakdown, by decarboxylation" EXACT []
synonym: "ornithine degradation, by decarboxylation" EXACT []
xref: MetaCyc:ORNDEG-PWY
is_a: GO:0006593 ! ornithine catabolic process

[Term]
id: GO:0019468
name: nopaline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nopaline (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "nopaline breakdown" EXACT []
synonym: "nopaline catabolism" EXACT []
synonym: "nopaline degradation" EXACT []
xref: MetaCyc:NOPALINEDEG-PWY
is_a: GO:0042219 ! cellular amino acid derivative catabolic process
is_a: GO:0046418 ! nopaline metabolic process

[Term]
id: GO:0019469
name: octopine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of octopine (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "octopine breakdown" EXACT []
synonym: "octopine catabolism" EXACT []
synonym: "octopine degradation" EXACT []
xref: MetaCyc:OCTOPINEDEG-PWY
is_a: GO:0042219 ! cellular amino acid derivative catabolic process
is_a: GO:0046419 ! octopine metabolic process

[Term]
id: GO:0019470
name: 4-hydroxyproline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline." [GOC:ai]
subset: gosubset_prok
synonym: "4-hydroxyproline breakdown" EXACT []
synonym: "4-hydroxyproline catabolism" EXACT []
synonym: "4-hydroxyproline degradation" EXACT []
xref: MetaCyc:HYDROXYPRODEG-PWY
is_a: GO:0009310 ! amine catabolic process
is_a: GO:0019471 ! 4-hydroxyproline metabolic process
is_a: GO:0042219 ! cellular amino acid derivative catabolic process

[Term]
id: GO:0019471
name: 4-hydroxyproline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls." [GOC:ai, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "4-hydroxyproline metabolism" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0019472
name: 4-hydroxyproline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline." [GOC:ai]
subset: gosubset_prok
synonym: "4-hydroxyproline anabolism" EXACT []
synonym: "4-hydroxyproline biosynthesis" EXACT []
synonym: "4-hydroxyproline formation" EXACT []
synonym: "4-hydroxyproline synthesis" EXACT []
is_a: GO:0009309 ! amine biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019471 ! 4-hydroxyproline metabolic process
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process

[Term]
id: GO:0019473
name: L-lysine catabolic process to glutarate, by acetylation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including glutarate, by acetylation." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-lysine breakdown to glutarate, by acetylation" EXACT []
synonym: "L-lysine degradation to glutarate, by acetylation" EXACT []
xref: MetaCyc:LYSDEGII-PWY
is_a: GO:0019477 ! L-lysine catabolic process

[Term]
id: GO:0019474
name: L-lysine catabolic process to acetyl-CoA
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-lysine breakdown to acetyl-CoA" EXACT []
synonym: "L-lysine degradation to acetyl-CoA" EXACT []
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0019477 ! L-lysine catabolic process

[Term]
id: GO:0019475
name: L-lysine catabolic process to acetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-lysine breakdown to acetate" EXACT []
synonym: "L-lysine degradation to acetate" EXACT []
synonym: "lysine fermentation" EXACT []
xref: MetaCyc:P163-PWY
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0019477 ! L-lysine catabolic process
is_a: GO:0019665 ! anaerobic amino acid catabolic process

[Term]
id: GO:0019476
name: D-lysine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid." [ChEBI:16855, GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-lysine breakdown" EXACT []
synonym: "D-lysine catabolism" EXACT []
synonym: "D-lysine degradation" EXACT []
is_a: GO:0006554 ! lysine catabolic process
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:0046441 ! D-lysine metabolic process

[Term]
id: GO:0019477
name: L-lysine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid." [GOC:go_curators, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-lysine breakdown" EXACT []
synonym: "L-lysine catabolism" EXACT []
synonym: "L-lysine degradation" EXACT []
is_a: GO:0006554 ! lysine catabolic process
is_a: GO:0046440 ! L-lysine metabolic process

[Term]
id: GO:0019478
name: D-amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg]
subset: gosubset_prok
synonym: "D-amino acid breakdown" EXACT []
synonym: "D-amino acid catabolism" EXACT []
synonym: "D-amino acid degradation" EXACT []
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0019479
name: L-alanine oxidation to D-lactate and ammonia
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-alanine to D-lactate and ammonia." [MetaCyc:ALACAT2-PWY]
subset: gosubset_prok
xref: MetaCyc:ALACAT2-PWY
is_a: GO:0042853 ! L-alanine catabolic process

[Term]
id: GO:0019480
name: L-alanine oxidation to pyruvate via D-alanine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-alanine to pyruvate, with D-alanine as an intermediate." [MetaCyc:ALADEG-PWY]
subset: gosubset_prok
xref: MetaCyc:ALADEG-PWY
is_a: GO:0042853 ! L-alanine catabolic process

[Term]
id: GO:0019481
name: L-alanine catabolic process, by transamination
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-alanine breakdown, by transamination" EXACT []
synonym: "L-alanine degradation, by transamination" EXACT []
xref: MetaCyc:ALANINE-DEG3-PWY
is_a: GO:0042853 ! L-alanine catabolic process

[Term]
id: GO:0019482
name: beta-alanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "beta-alanine metabolism" EXACT []
xref: Wikipedia:Beta-alanine
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0019483
name: beta-alanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "beta-alanine anabolism" EXACT []
synonym: "beta-alanine biosynthesis" EXACT []
synonym: "beta-alanine formation" EXACT []
synonym: "beta-alanine synthesis" EXACT []
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0019482 ! beta-alanine metabolic process

[Term]
id: GO:0019484
name: beta-alanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "beta-alanine breakdown" EXACT []
synonym: "beta-alanine catabolism" EXACT []
synonym: "beta-alanine degradation" EXACT []
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0019482 ! beta-alanine metabolic process

[Term]
id: GO:0019485
name: beta-alanine catabolic process to L-alanine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including L-alanine." [GOC:go_curators]
subset: gosubset_prok
synonym: "beta-alanine breakdown to L-alanine" EXACT []
synonym: "beta-alanine degradation to L-alanine" EXACT []
is_a: GO:0019484 ! beta-alanine catabolic process
is_a: GO:0042851 ! L-alanine metabolic process

[Term]
id: GO:0019486
name: beta-alanine catabolic process to mevalonate semialdehyde, by transamination
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including mevalonate semialdehyde, by transamination." [GOC:go_curators]
subset: gosubset_prok
synonym: "beta-alanine breakdown to mevalonate semialdehyde, by transamination" EXACT []
synonym: "beta-alanine degradation to mevalonate semialdehyde, by transamination" EXACT []
xref: MetaCyc:BETA-ALA-DEGRADATION-I-PWY
is_a: GO:0019484 ! beta-alanine catabolic process

[Term]
id: GO:0019487
name: anaerobic acetylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetylene, a colorless, volatile, explosive gas, that occur in the absence of oxygen." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "anaerobic acetylene breakdown" EXACT []
synonym: "anaerobic acetylene catabolism" EXACT []
synonym: "anaerobic acetylene degradation" EXACT []
synonym: "anaerobic ethyne catabolic process" EXACT []
synonym: "anaerobic ethyne catabolism" EXACT []
xref: MetaCyc:P161-PWY
is_a: GO:0018864 ! acetylene metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043454 ! alkyne catabolic process

[Term]
id: GO:0019488
name: ribitol catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ribitol to form xylulose 5-phosphate. Ribitol is initially converted to D-ribulose, which is phosphorylated to form ribulose 5-phosphate, which is then converted into xylulose 5-phosphate." [MetaCyc:RIBITOLUTIL-PWY]
subset: gosubset_prok
synonym: "ribitol breakdown to xylulose 5-phosphate" EXACT []
synonym: "ribitol degradation to xylulose 5-phosphate" EXACT []
synonym: "ribitol utilization" RELATED []
xref: MetaCyc:RIBITOLUTIL-PWY
is_a: GO:0046363 ! ribitol catabolic process
is_a: GO:0051167 ! xylulose 5-phosphate metabolic process

[Term]
id: GO:0019489
name: methylgallate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai]
subset: gosubset_prok
synonym: "methylgallate metabolism" EXACT []
is_a: GO:0018918 ! gallate metabolic process

[Term]
id: GO:0019490
name: 2-aminobenzenesulfonate desulfonation
namespace: biological_process
def: "The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [http://umbbd.ahc.umn.edu/abs/abs_map.html, UM-BBD_pathwayID:abs]
subset: gosubset_prok
synonym: "2-aminobenzenesulphonate desulphonation" EXACT []
xref: MetaCyc:2ASDEG-PWY
is_a: GO:0018868 ! 2-aminobenzenesulfonate metabolic process

[Term]
id: GO:0019491
name: ectoine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218]
subset: gosubset_prok
synonym: "ectoine anabolism" EXACT []
synonym: "ectoine biosynthesis" EXACT []
synonym: "ectoine formation" EXACT []
synonym: "ectoine synthesis" EXACT []
xref: MetaCyc:P101-PWY
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042399 ! ectoine metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0019492
name: proline salvage
namespace: biological_process
def: "Any process which produces the amino acid proline from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "proline cycling" EXACT []
is_a: GO:0006561 ! proline biosynthetic process
is_a: GO:0043102 ! amino acid salvage

[Term]
id: GO:0019493
name: arginine catabolic process to proline
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline." [GOC:go_curators]
subset: gosubset_prok
synonym: "arginine breakdown to proline" EXACT []
synonym: "arginine degradation to proline" EXACT []
xref: MetaCyc:ARG-PRO-PWY
is_a: GO:0006527 ! arginine catabolic process
is_a: GO:0006560 ! proline metabolic process

[Term]
id: GO:0019495
name: proline catabolic process to 2-oxoglutarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including 2-oxoglutarate." [GOC:go_curators]
subset: gosubset_prok
synonym: "proline breakdown to 2-oxoglutarate" EXACT []
synonym: "proline catabolic process to 2-ketoglutarate" EXACT []
synonym: "proline catabolic process to alpha-ketoglutarate" EXACT []
synonym: "proline catabolic process to alpha-oxoglutarate" EXACT []
synonym: "proline catabolism to 2-ketoglutarate" EXACT []
synonym: "proline catabolism to alpha-ketoglutarate" EXACT []
synonym: "proline catabolism to alpha-oxoglutarate" EXACT []
synonym: "proline degradation to 2-oxoglutarate" EXACT []
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0006562 ! proline catabolic process

[Term]
id: GO:0019496
name: serine-isocitrate lyase pathway
namespace: biological_process
def: "A one-carbon metabolic process in which acetyl-CoA is produced from formaldehyde and carbon dioxide." [ISBN:0387961534]
subset: gosubset_prok
is_a: GO:0006730 ! one-carbon metabolic process

[Term]
id: GO:0019497
name: hexachlorocyclohexane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hexachlorocyclohexane, a cyclohexane derivative with 6 chlorine atoms attached to the hexane ring. Hexachlorocyclohexane consists of a mixture of 8 different isomers and was used a commercial insecticide. It is persistent in the environment, causing serious soil pollution." [UM-BBD_pathwayID:ghch, UM-BBD_pathwayID:hch]
subset: gosubset_prok
synonym: "hexachlorocyclohexane metabolism" EXACT []
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process

[Term]
id: GO:0019498
name: n-octane oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of n-octane to octanoyl-CoA." [MetaCyc:P221-PWY]
subset: gosubset_prok
xref: MetaCyc:P221-PWY
is_a: GO:0018939 ! n-octane metabolic process

[Term]
id: GO:0019499
name: cyanide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration, reacting with the ferric form of cytochrome aa3 and thus blocking the electron transport chain." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cyanide metabolism" EXACT []
is_a: GO:0034641 ! cellular nitrogen compound metabolic process

[Term]
id: GO:0019500
name: cyanide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cyanide breakdown" EXACT []
synonym: "cyanide catabolism" EXACT []
synonym: "cyanide degradation" EXACT []
xref: MetaCyc:P401-PWY
is_a: GO:0019499 ! cyanide metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process

[Term]
id: GO:0019501
name: arsonoacetate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arsonoacetate, a synthetic, organic compound containing a single arsenic atom." [GOC:jl]
subset: gosubset_prok
synonym: "arsonoacetate breakdown" EXACT []
synonym: "arsonoacetate catabolism" EXACT []
synonym: "arsonoacetate degradation" EXACT []
xref: MetaCyc:P482-PWY
is_a: GO:0018872 ! arsonoacetate metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0019502
name: stachydrine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline found in alfalfa, chrysanthemum, and citrus plants." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "stachydrine metabolism" EXACT []
is_a: GO:0006577 ! betaine metabolic process

[Term]
id: GO:0019503
name: stachydrine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." [GOC:ai]
subset: gosubset_prok
synonym: "stachydrine anabolism" EXACT []
synonym: "stachydrine biosynthesis" EXACT []
synonym: "stachydrine formation" EXACT []
synonym: "stachydrine synthesis" EXACT []
is_a: GO:0006578 ! betaine biosynthetic process
is_a: GO:0019502 ! stachydrine metabolic process

[Term]
id: GO:0019504
name: stachydrine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." [GOC:ai]
subset: gosubset_prok
synonym: "stachydrine breakdown" EXACT []
synonym: "stachydrine catabolism" EXACT []
synonym: "stachydrine degradation" EXACT []
xref: MetaCyc:P561-PWY
is_a: GO:0006579 ! betaine catabolic process
is_a: GO:0019502 ! stachydrine metabolic process

[Term]
id: GO:0019505
name: resorcinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving resorcinol (C6H4(OH)2), a benzene derivative with many applications, including dyes, explosives, resins and as an antiseptic." [GOC:jl, http://www.speclab.com/compound/c108463.htm]
subset: gosubset_prok
synonym: "1,3-benzenediol metabolic process" EXACT []
synonym: "1,3-benzenediol metabolism" EXACT []
synonym: "1,3-dihydroxybenzene metabolic process" EXACT []
synonym: "1,3-dihydroxybenzene metabolism" EXACT []
synonym: "resorcinol metabolism" EXACT []
xref: MetaCyc:P343-PWY
is_a: GO:0018958 ! phenol metabolic process
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process

[Term]
id: GO:0019506
name: phenylmercury acetate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group." [GOC:ai]
subset: gosubset_prok
synonym: "phenylmercury acetate breakdown" EXACT []
synonym: "phenylmercury acetate catabolism" EXACT []
synonym: "phenylmercury acetate degradation" EXACT []
xref: MetaCyc:P641-PWY
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0046412 ! phenylmercury acetate metabolic process
is_a: GO:0046413 ! organomercury catabolic process

[Term]
id: GO:0019507
name: pyridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "pyridine metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0019508
name: 2,5-dihydroxypyridine catabolic process to fumarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine to form fumarate. 2,5-dihydroxypyridine is dioxygenated to give maleamate and formate; the maleamate from this reaction is then converted to maleate, which is then isomerized to fumurate." [MetaCyc:PWY-722]
subset: gosubset_prok
synonym: "2,5-dihydroxypyridine breakdown to fumarate" EXACT []
synonym: "2,5-dihydroxypyridine degradation to fumarate" EXACT []
synonym: "2,5-dihydroxypyridine utilization" RELATED []
synonym: "maleamate pathway" EXACT []
xref: MetaCyc:PWY-722
is_a: GO:0051166 ! 2,5-dihydroxypyridine catabolic process

[Term]
id: GO:0019509
name: L-methionine salvage from methylthioadenosine
namespace: biological_process
def: "The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361]
subset: gosubset_prok
synonym: "methionine recycling" NARROW []
synonym: "methionine regeneration" NARROW []
synonym: "methionine salvage from methylthioadenosine" EXACT [GOC:mah]
synonym: "methionine salvage pathway" EXACT []
xref: MetaCyc:PWY-4361
is_a: GO:0043102 ! amino acid salvage
is_a: GO:0071267 ! L-methionine salvage

[Term]
id: GO:0019510
name: S-adenosylhomocysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "S-adenosylhomocysteine breakdown" EXACT []
synonym: "S-adenosylhomocysteine catabolism" EXACT []
synonym: "S-adenosylhomocysteine degradation" EXACT []
xref: MetaCyc:ADENOSYLHOMOCYSCAT-PWY
is_a: GO:0000098 ! sulfur amino acid catabolic process
is_a: GO:0046498 ! S-adenosylhomocysteine metabolic process

[Term]
id: GO:0019511
name: peptidyl-proline hydroxylation
namespace: biological_process
alt_id: GO:0006472
def: "The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0019512
name: lactose catabolic process via tagatose-6-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate tagatose-6-phosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "lactose breakdown via tagatose-6-phosphate" EXACT []
synonym: "lactose degradation via tagatose-6-phosphate" EXACT []
xref: MetaCyc:LACTOSECAT-PWY
is_a: GO:0005990 ! lactose catabolic process

[Term]
id: GO:0019513
name: lactose catabolic process, using glucoside 3-dehydrogenase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactose, catalyzed by the enzyme glucoside 3-dehydrogenase (EC:1.1.99.13)." [GOC:jl]
subset: gosubset_prok
synonym: "lactose breakdown, using glucoside 3-dehydrogenase" EXACT []
synonym: "lactose degradation, using glucoside 3-dehydrogenase" EXACT []
xref: MetaCyc:LACTOSEUTIL-PWY
is_a: GO:0005990 ! lactose catabolic process

[Term]
id: GO:0019514
name: lactose hydrolysis
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because hydrolysis is a reaction.
is_obsolete: true
consider: GO:0004565

[Term]
id: GO:0019515
name: lactose catabolic process via UDP-galactose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate UDP-galactose." [GOC:go_curators]
subset: gosubset_prok
synonym: "lactose breakdown via UDP-galactose" EXACT []
synonym: "lactose degradation via UDP-galactose" EXACT []
is_a: GO:0005990 ! lactose catabolic process

[Term]
id: GO:0019516
name: lactate oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the conversion of lactate to other compounds, such as pyruvate, with concomitant loss of electrons." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006089 ! lactate metabolic process

[Term]
id: GO:0019517
name: threonine catabolic process to D-lactate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate." [GOC:jl, MetaCyc:THRDLCTCAT-PWY]
subset: gosubset_prok
synonym: "threonine breakdown to D-lactate" EXACT []
synonym: "threonine catabolic process to methylglyoxal" EXACT [MetaCyc:THRDLCTCAT-PWY]
synonym: "threonine catabolic process to pyruvate" RELATED [GOC:mah]
synonym: "threonine catabolism to D-lactate" EXACT [GOC:mah]
synonym: "threonine degradation to D-lactate" EXACT []
xref: MetaCyc:THRDLCTCAT-PWY
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0006567 ! threonine catabolic process

[Term]
id: GO:0019518
name: threonine catabolic process to glycine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid) to form the compound glycine." [GOC:mah, MetaCyc:THREONINE-DEG2-PWY]
subset: gosubset_prok
synonym: "threonine breakdown to glycine" EXACT [GOC:mah]
synonym: "threonine catabolic process to pyruvate" RELATED [GOC:mah]
synonym: "threonine catabolism to glycine" EXACT [GOC:mah]
synonym: "threonine degradation to glycine" EXACT [GOC:mah]
xref: MetaCyc:THREONINE-DEG2-PWY
is_a: GO:0006567 ! threonine catabolic process

[Term]
id: GO:0019519
name: pentitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pentitol metabolism" EXACT []
is_a: GO:0019400 ! alditol metabolic process

[Term]
id: GO:0019520
name: aldonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aldonic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0019521
name: D-gluconate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-gluconate metabolism" EXACT []
is_a: GO:0019520 ! aldonic acid metabolic process

[Term]
id: GO:0019522
name: ketogluconate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ketogluconate metabolism" EXACT []
xref: MetaCyc:KETOGLUCONMET-PWY
is_a: GO:0019520 ! aldonic acid metabolic process

[Term]
id: GO:0019523
name: L-idonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:ai, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "L-idonate metabolism" EXACT []
xref: MetaCyc:IDNCAT-PWY
is_a: GO:0019522 ! ketogluconate metabolic process

[Term]
id: GO:0019524
name: D-dehydro-D-gluconate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-dehydro-D-gluconate, the anion of D-dehydro-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-dehydro-D-gluconate breakdown" EXACT []
synonym: "D-dehydro-D-gluconate catabolism" EXACT []
synonym: "D-dehydro-D-gluconate degradation" EXACT []
xref: MetaCyc:DHGLUCONATE-PYR-CAT-PWY
is_a: GO:0019525 ! D-dehydro-D-gluconate metabolic process
is_a: GO:0046176 ! aldonic acid catabolic process

[Term]
id: GO:0019525
name: D-dehydro-D-gluconate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-dehydro-D-gluconate, the anion of D-dehydro-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-dehydro-D-gluconate metabolism" EXACT []
is_a: GO:0019520 ! aldonic acid metabolic process

[Term]
id: GO:0019526
name: pentitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pentitol anabolism" EXACT []
synonym: "pentitol biosynthesis" EXACT []
synonym: "pentitol formation" EXACT []
synonym: "pentitol synthesis" EXACT []
is_a: GO:0019401 ! alditol biosynthetic process
is_a: GO:0019519 ! pentitol metabolic process

[Term]
id: GO:0019527
name: pentitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pentitol breakdown" EXACT []
synonym: "pentitol catabolism" EXACT []
synonym: "pentitol degradation" EXACT []
is_a: GO:0019405 ! alditol catabolic process
is_a: GO:0019519 ! pentitol metabolic process

[Term]
id: GO:0019528
name: D-arabitol catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-arabitol to form xylulose 5-phosphate. D-arabitol is converted into D-xylulose, which is then phosphorylated to form D-xylulose-5-phosphate." [MetaCyc:DARABITOLUTIL-PWY]
subset: gosubset_prok
synonym: "D-arabitol breakdown to xylulose 5-phosphate" EXACT []
synonym: "D-arabitol degradation" RELATED []
synonym: "D-arabitol degradation to xylulose 5-phosphate" EXACT []
synonym: "D-arabitol utilization" RELATED []
xref: MetaCyc:DARABITOLUTIL-PWY
is_a: GO:0051159 ! D-arabitol catabolic process
is_a: GO:0051167 ! xylulose 5-phosphate metabolic process

[Term]
id: GO:0019529
name: taurine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461]
subset: gosubset_prok
synonym: "taurine breakdown" EXACT []
synonym: "taurine catabolism" EXACT []
synonym: "taurine degradation" EXACT []
xref: MetaCyc:TAURINEDEG-PWY
is_a: GO:0019530 ! taurine metabolic process
is_a: GO:0042219 ! cellular amino acid derivative catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0019530
name: taurine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461]
subset: gosubset_prok
synonym: "taurine metabolism" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0019531
name: oxalate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "oxalic acid transporter activity" EXACT []
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity

[Term]
id: GO:0019532
name: oxalate transport
namespace: biological_process
def: "The directed movement of oxalate into, out of, within or between cells by means of some external agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ethanedioate transport" EXACT []
synonym: "ethanedioic acid transport" EXACT []
synonym: "oxalic acid transport" EXACT []
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0019533
name: cellobiose transport
namespace: biological_process
def: "The directed movement of cellobiose into, out of, within or between cells by means of some external agent such as a transporter or pore. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015766 ! disaccharide transport

[Term]
id: GO:0019534
name: toxin transporter activity
namespace: molecular_function
def: "Enables the directed movement of a toxin into, out of, within or between cells. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0005215 ! transporter activity

[Term]
id: GO:0019535
name: ferric-vibriobactin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of ferric-vibriobactin ions from one side of a membrane to the other." [GOC:ai]
is_a: GO:0015343 ! siderophore-iron transmembrane transporter activity

[Term]
id: GO:0019536
name: vibriobactin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vibriobactin, the major siderophore produced by Vibrio cholerae." [GOC:jl, PMID:11112537]
subset: gosubset_prok
synonym: "vibriobactin metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process

[Term]
id: GO:0019537
name: vibriobactin biosynthetic process
namespace: biological_process
alt_id: GO:0031195
alt_id: GO:0031196
def: "The chemical reactions and pathways resulting in the formation of vibriobactin, the major siderophore produced by Vibrio cholerae." [GOC:jl, PMID:11112537]
subset: gosubset_prok
synonym: "vibriobactin anabolism" EXACT []
synonym: "vibriobactin biosynthesis" EXACT []
synonym: "vibriobactin biosynthetic process, peptide formation" NARROW []
synonym: "vibriobactin biosynthetic process, peptide modification" NARROW []
synonym: "vibriobactin formation" EXACT []
synonym: "vibriobactin synthesis" EXACT []
is_a: GO:0019536 ! vibriobactin metabolic process
is_a: GO:0019540 ! siderophore biosynthetic process from catechol

[Term]
id: GO:0019538
name: protein metabolic process
namespace: biological_process
alt_id: GO:0006411
def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification." [GOC:ma]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "protein metabolic process and modification" EXACT []
synonym: "protein metabolism" EXACT []
synonym: "protein metabolism and modification" EXACT []
xref: Wikipedia:Protein_metabolism
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044238 ! primary metabolic process

[Term]
id: GO:0019539
name: siderophore biosynthetic process from hydroxamic acid
namespace: biological_process
alt_id: GO:0031197
alt_id: GO:0031198
def: "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including hydroxamic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "siderochrome biosynthesis from hydroxamic acid" NARROW []
synonym: "siderochrome biosynthetic process from hydroxamic acid" NARROW []
synonym: "siderophore anabolism from hydroxamic acid" EXACT []
synonym: "siderophore biosynthetic process from hydroxamic acid, peptide formation" NARROW []
synonym: "siderophore biosynthetic process from hydroxamic acid, peptide modification" NARROW []
synonym: "siderophore formation from hydroxamic acid" EXACT []
synonym: "siderophore synthesis from hydroxamic acid" EXACT []
is_a: GO:0019290 ! siderophore biosynthetic process

[Term]
id: GO:0019540
name: siderophore biosynthetic process from catechol
namespace: biological_process
alt_id: GO:0031189
alt_id: GO:0031190
def: "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including catechol." [GOC:go_curators]
subset: gosubset_prok
synonym: "siderochrome biosynthesis from catechol" NARROW []
synonym: "siderochrome biosynthetic process from catechol" NARROW []
synonym: "siderophore anabolism from catechol" EXACT []
synonym: "siderophore biosynthetic process from catechol, peptide formation" NARROW []
synonym: "siderophore biosynthetic process from catechol, peptide modification" NARROW []
synonym: "siderophore formation from catechol" EXACT []
synonym: "siderophore synthesis from catechol" EXACT []
is_a: GO:0009712 ! catechol metabolic process
is_a: GO:0019290 ! siderophore biosynthetic process

[Term]
id: GO:0019541
name: propionate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "propionate metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0019542
name: propionate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "propionate anabolism" EXACT []
synonym: "propionate biosynthesis" EXACT []
synonym: "propionate formation" EXACT []
synonym: "propionate synthesis" EXACT []
is_a: GO:0019541 ! propionate metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0019543
name: propionate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "propionate breakdown" EXACT []
synonym: "propionate catabolism" EXACT []
synonym: "propionate degradation" EXACT []
is_a: GO:0019541 ! propionate metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0019544
name: arginine catabolic process to glutamate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including glutamate." [GOC:go_curators]
subset: gosubset_prok
synonym: "arginine breakdown to glutamate" EXACT []
synonym: "arginine degradation to glutamate" EXACT []
xref: MetaCyc:ARG-GLU-PWY
xref: MetaCyc:ARGASEDEG-PWY
is_a: GO:0006527 ! arginine catabolic process
is_a: GO:0006536 ! glutamate metabolic process

[Term]
id: GO:0019545
name: arginine catabolic process to succinate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including succinate." [GOC:go_curators]
subset: gosubset_prok
synonym: "arginine breakdown to succinate" EXACT []
synonym: "arginine degradation to succinate" EXACT []
xref: MetaCyc:ARGDEG-III-PWY
xref: MetaCyc:ARGDEG-IV-PWY
xref: MetaCyc:ARGDEG-V-PWY
xref: MetaCyc:AST-PWY
is_a: GO:0006105 ! succinate metabolic process
is_a: GO:0006527 ! arginine catabolic process

[Term]
id: GO:0019546
name: arginine deiminase pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine and CO2, using the enzyme arginine deiminase." [GOC:mah, MetaCyc:ARGDEGRAD-PWY]
subset: gosubset_prok
xref: MetaCyc:ARGDEGRAD-PWY
is_a: GO:0006527 ! arginine catabolic process

[Term]
id: GO:0019547
name: arginine catabolic process to ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine." [GOC:go_curators]
subset: gosubset_prok
synonym: "arginine breakdown to ornithine" EXACT []
synonym: "arginine degradation to ornithine" EXACT []
is_a: GO:0006527 ! arginine catabolic process
is_a: GO:0006591 ! ornithine metabolic process

[Term]
id: GO:0019548
name: arginine catabolic process to spermine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including spermine." [GOC:go_curators]
subset: gosubset_prok
synonym: "arginine breakdown to spermine" EXACT []
synonym: "arginine degradation to spermine" EXACT []
xref: MetaCyc:ARGSPECAT-PWY
is_a: GO:0006527 ! arginine catabolic process
is_a: GO:0008215 ! spermine metabolic process

[Term]
id: GO:0019549
name: glutamate catabolic process to succinate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including succinate." [GOC:go_curators, MetaCyc:PWY-4321]
subset: gosubset_prok
synonym: "glutamate breakdown to succinate" EXACT []
synonym: "glutamate degradation to succinate" EXACT []
xref: MetaCyc:PWY-4321
is_a: GO:0006105 ! succinate metabolic process
is_a: GO:0006538 ! glutamate catabolic process

[Term]
id: GO:0019550
name: glutamate catabolic process to aspartate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate breakdown to aspartate" EXACT []
synonym: "glutamate degradation to aspartate" EXACT []
xref: MetaCyc:GLUTDEG-PWY
is_a: GO:0006531 ! aspartate metabolic process
is_a: GO:0006538 ! glutamate catabolic process

[Term]
id: GO:0019551
name: glutamate catabolic process to 2-oxoglutarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate breakdown to 2-oxoglutarate" EXACT []
synonym: "glutamate catabolic process to 2-ketoglutarate" EXACT []
synonym: "glutamate catabolic process to alpha-ketoglutarate" EXACT []
synonym: "glutamate catabolic process to alpha-oxoglutarate" EXACT []
synonym: "glutamate catabolism to 2-ketoglutarate" EXACT []
synonym: "glutamate catabolism to alpha-ketoglutarate" EXACT []
synonym: "glutamate catabolism to alpha-oxoglutarate" EXACT []
synonym: "glutamate degradation to 2-oxoglutarate" EXACT []
xref: MetaCyc:GLUTAMATE-DEG1-PWY
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0006106 ! fumarate metabolic process
is_a: GO:0006538 ! glutamate catabolic process

[Term]
id: GO:0019552
name: glutamate catabolic process via 2-hydroxyglutarate
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-hydroxyglutarate, yielding energy in the form of ATP." [MetaCyc:P162-PWY]
subset: gosubset_prok
synonym: "glutamate fermentation via 2-hydroxyglutarate" EXACT []
xref: MetaCyc:P162-PWY
is_a: GO:0019670 ! anaerobic glutamate catabolic process

[Term]
id: GO:0019553
name: glutamate catabolic process via L-citramalate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-citramalate." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate breakdown via L-citramalate" EXACT []
synonym: "glutamate degradation via L-citramalate" EXACT []
xref: MetaCyc:GLUDEG-II-PWY
is_a: GO:0006538 ! glutamate catabolic process

[Term]
id: GO:0019554
name: glutamate catabolic process to oxaloacetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including oxaloacetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate breakdown to oxaloacetate" EXACT []
synonym: "glutamate degradation to oxaloacetate" EXACT []
is_a: GO:0006107 ! oxaloacetate metabolic process
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0019555
name: glutamate catabolic process to ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including ornithine." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutamate breakdown to ornithine" EXACT []
synonym: "glutamate degradation to ornithine" EXACT []
xref: MetaCyc:GLUTORN-PWY
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0006591 ! ornithine metabolic process

[Term]
id: GO:0019556
name: histidine catabolic process to glutamate and formamide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine breakdown to glutamate and formamide" EXACT []
synonym: "histidine degradation to glutamate and formamide" EXACT []
xref: MetaCyc:HISDEG-PWY
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0006548 ! histidine catabolic process

[Term]
id: GO:0019557
name: histidine catabolic process to glutamate and formate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formate." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine breakdown to glutamate and formate" EXACT []
synonym: "histidine degradation to glutamate and formate" EXACT []
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0006548 ! histidine catabolic process
is_a: GO:0015942 ! formate metabolic process

[Term]
id: GO:0019558
name: histidine catabolic process to 2-oxoglutarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including 2-oxoglutarate." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine breakdown to 2-oxoglutarate" EXACT []
synonym: "histidine catabolic process to 2-ketoglutarate" EXACT []
synonym: "histidine catabolic process to alpha-ketoglutarate" EXACT []
synonym: "histidine catabolic process to alpha-oxoglutarate" EXACT []
synonym: "histidine catabolism to 2-ketoglutarate" EXACT []
synonym: "histidine catabolism to alpha-ketoglutarate" EXACT []
synonym: "histidine catabolism to alpha-oxoglutarate" EXACT []
synonym: "histidine degradation to 2-oxoglutarate" EXACT []
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0006548 ! histidine catabolic process

[Term]
id: GO:0019559
name: histidine catabolic process to imidazol-5-yl-lactate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including imidazol-5-yl-lactate." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine breakdown to imidazol-5-yl-lactate" EXACT []
synonym: "histidine degradation to imidazol-5-yl-lactate" EXACT []
xref: MetaCyc:HISTDEG-PWY
is_a: GO:0006548 ! histidine catabolic process

[Term]
id: GO:0019560
name: histidine catabolic process to hydantoin-5-propionate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including hydantoin-5-propionate." [GOC:go_curators]
subset: gosubset_prok
synonym: "histidine breakdown to hydantoin-5-propionate" EXACT []
synonym: "histidine degradation to hydantoin-5-propionate" EXACT []
xref: MetaCyc:HISHP-PWY
is_a: GO:0006548 ! histidine catabolic process

[Term]
id: GO:0019561
name: anaerobic phenylalanine oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine under anaerobic conditions; occurs via the intermediates phenylpyruvate and phenylacetaldehyde." [GOC:mah, MetaCyc:ANAPHENOXI-PWY]
subset: gosubset_prok
xref: MetaCyc:ANAPHENOXI-PWY
is_a: GO:0006559 ! L-phenylalanine catabolic process

[Term]
id: GO:0019562
name: phenylalanine catabolic process to phosphoenolpyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine into other compounds, including phosphoenolpyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "phenylalanine breakdown to phosphoenolpyruvate" EXACT []
synonym: "phenylalanine degradation to phosphoenolpyruvate" EXACT []
xref: MetaCyc:PHENYLALANINE-DEG1-PWY
is_a: GO:0006559 ! L-phenylalanine catabolic process

[Term]
id: GO:0019563
name: glycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycerol breakdown" EXACT []
synonym: "glycerol catabolism" EXACT []
synonym: "glycerol degradation" EXACT []
xref: MetaCyc:PWY-4261
xref: MetaCyc:PWY0-381
is_a: GO:0006071 ! glycerol metabolic process
is_a: GO:0019405 ! alditol catabolic process

[Term]
id: GO:0019564
name: aerobic glycerol catabolic process
namespace: biological_process
alt_id: GO:0019565
def: "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, in the presence of oxygen." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aerobic glycerol breakdown" EXACT []
synonym: "aerobic glycerol catabolism" EXACT []
synonym: "aerobic glycerol degradation" EXACT []
synonym: "aerobic glycerol fermentation" RELATED []
xref: MetaCyc:PWY0-381
is_a: GO:0019563 ! glycerol catabolic process

[Term]
id: GO:0019566
name: arabinose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arabinose, arabino-pentose. L-Arabinose occurs both free, for example in the heartwood of many conifers, and in the combined state, as a constituent of plant hemicelluloses, bacterial polysaccharides etc. D-arabinose is a constituent of arabinonucleosides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "arabinose metabolism" EXACT []
is_a: GO:0019321 ! pentose metabolic process

[Term]
id: GO:0019567
name: arabinose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of arabinose, arabino-pentose." [GOC:ai]
subset: gosubset_prok
synonym: "arabinose anabolism" EXACT []
synonym: "arabinose biosynthesis" EXACT []
synonym: "arabinose formation" EXACT []
synonym: "arabinose synthesis" EXACT []
is_a: GO:0019322 ! pentose biosynthetic process
is_a: GO:0019566 ! arabinose metabolic process

[Term]
id: GO:0019568
name: arabinose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose." [GOC:ai]
subset: gosubset_prok
synonym: "arabinose breakdown" EXACT []
synonym: "arabinose catabolism" EXACT []
synonym: "arabinose degradation" EXACT []
is_a: GO:0019323 ! pentose catabolic process
is_a: GO:0019566 ! arabinose metabolic process

[Term]
id: GO:0019569
name: L-arabinose catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including xylulose 5-phosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-arabinose breakdown to xylulose 5-phosphate" EXACT []
synonym: "L-arabinose degradation to xylulose 5-phosphate" EXACT []
xref: MetaCyc:ARABCAT-PWY
is_a: GO:0019572 ! L-arabinose catabolic process
is_a: GO:0051167 ! xylulose 5-phosphate metabolic process

[Term]
id: GO:0019570
name: L-arabinose catabolic process to 2-oxoglutarate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including 2-oxoglutarate." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-arabinose breakdown to 2-oxoglutarate" EXACT []
synonym: "L-arabinose catabolic process to 2-ketoglutarate" EXACT []
synonym: "L-arabinose catabolic process to alpha-ketoglutarate" EXACT []
synonym: "L-arabinose catabolic process to alpha-oxoglutarate" EXACT []
synonym: "L-arabinose catabolism to 2-ketoglutarate" EXACT []
synonym: "L-arabinose catabolism to alpha-ketoglutarate" EXACT []
synonym: "L-arabinose catabolism to alpha-oxoglutarate" EXACT []
synonym: "L-arabinose degradation to 2-oxoglutarate" EXACT []
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0019572 ! L-arabinose catabolic process

[Term]
id: GO:0019571
name: D-arabinose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-arabinose, the D-enantiomer of arabino-pentose." [ChEBI:17108, GOC:go_curators, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-arabinose breakdown" EXACT []
synonym: "D-arabinose catabolism" EXACT []
synonym: "D-arabinose degradation" EXACT []
is_a: GO:0019568 ! arabinose catabolic process
is_a: GO:0046372 ! D-arabinose metabolic process

[Term]
id: GO:0019572
name: L-arabinose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose, the L-enantiomer of arabino-pentose." [ChEBI:30849, GOC:go_curators, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-arabinose breakdown" EXACT []
synonym: "L-arabinose catabolism" EXACT []
synonym: "L-arabinose degradation" EXACT []
is_a: GO:0019568 ! arabinose catabolic process
is_a: GO:0046373 ! L-arabinose metabolic process

[Term]
id: GO:0019573
name: D-arabinose catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-arabinose to form xylulose 5-phosphate. D-arabinose is converted into D-ribulose, which is phosphorylated to ribulose-5-phosphate, which is isomerized to give D-xylulose-5-phosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "D-arabinose breakdown to xylulose 5-phosphate" EXACT []
synonym: "D-arabinose degradation to xylulose 5-phosphate" EXACT []
xref: MetaCyc:DARABCAT-PWY
is_a: GO:0019571 ! D-arabinose catabolic process
is_a: GO:0051167 ! xylulose 5-phosphate metabolic process

[Term]
id: GO:0019574
name: sucrose catabolic process, using glucoside 3-dehydrogenase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sucrose, catalyzed by the enzyme glucoside 3-dehydrogenase (EC:1.1.99.13)." [GOC:jl]
subset: gosubset_prok
synonym: "sucrose breakdown, using glucoside 3-dehydrogenase" EXACT []
synonym: "sucrose catabolism, using glucoside 3-dehydrogenase" EXACT []
synonym: "sucrose degradation, using glucoside 3-dehydrogenase" EXACT []
xref: MetaCyc:SUCROSEUTIL2-PWY
is_a: GO:0005987 ! sucrose catabolic process

[Term]
id: GO:0019575
name: sucrose catabolic process, using beta-fructofuranosidase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sucrose, catalyzed by the enzyme beta-fructofuranosidase (EC:3.2.1.26)." [GOC:jl]
subset: gosubset_prok
synonym: "sucrose breakdown, using beta-fructofuranosidase" EXACT []
synonym: "sucrose catabolism, using beta-fructofuranosidase" EXACT []
synonym: "sucrose degradation, using beta-fructofuranosidase" EXACT []
xref: MetaCyc:SUCUTIL-PWY
is_a: GO:0005987 ! sucrose catabolic process

[Term]
id: GO:0019576
name: aerobic fructose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the presence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "aerobic fructose breakdown" EXACT []
synonym: "aerobic fructose catabolism" EXACT []
synonym: "aerobic fructose degradation" EXACT []
is_a: GO:0006001 ! fructose catabolic process

[Term]
id: GO:0019577
name: aldaric acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aldaric acid metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0019578
name: aldaric acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aldaric acid anabolism" EXACT []
synonym: "aldaric acid biosynthesis" EXACT []
synonym: "aldaric acid formation" EXACT []
synonym: "aldaric acid synthesis" EXACT []
is_a: GO:0016051 ! carbohydrate biosynthetic process
is_a: GO:0019577 ! aldaric acid metabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0019579
name: aldaric acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aldaric acid breakdown" EXACT []
synonym: "aldaric acid catabolism" EXACT []
synonym: "aldaric acid degradation" EXACT []
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0019577 ! aldaric acid metabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process

[Term]
id: GO:0019580
name: galactarate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactarate, an anion of galactaric acid, the meso-aldaric acid derived from both D- and L-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "galactarate metabolism" EXACT []
synonym: "mucic acid metabolic process" EXACT []
synonym: "mucic acid metabolism" EXACT []
is_a: GO:0019577 ! aldaric acid metabolic process

[Term]
id: GO:0019582
name: D-galactarate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-galactarate, the D-enantiomer of the anion of galactaric acid." [GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-galactarate breakdown" EXACT []
synonym: "D-galactarate catabolism" EXACT []
synonym: "D-galactarate degradation" EXACT []
xref: MetaCyc:GALACTARDEG-PWY
is_a: GO:0046392 ! galactarate catabolic process
is_a: GO:0046393 ! D-galactarate metabolic process

[Term]
id: GO:0019583
name: galactonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactonate, the anion of galactonic acid, an organic acid derived from the sugar galactose." [GOC:ai]
subset: gosubset_prok
synonym: "galactonate metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0019584
name: galactonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactonate, the anion of galactonic acid." [GOC:ai]
subset: gosubset_prok
synonym: "galactonate breakdown" EXACT []
synonym: "galactonate catabolism" EXACT []
synonym: "galactonate degradation" EXACT []
xref: MetaCyc:GALACTCAT-PWY
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0019583 ! galactonate metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0019585
name: glucuronate metabolic process
namespace: biological_process
alt_id: GO:0019699
def: "The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glucuronate metabolism" EXACT []
xref: Wikipedia:Glucuronic_acid
is_a: GO:0006063 ! uronic acid metabolic process

[Term]
id: GO:0019586
name: galacturonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galacturonate, the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "galacturonate metabolism" EXACT []
is_a: GO:0006063 ! uronic acid metabolic process

[Term]
id: GO:0019588
name: anaerobic glycerol catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol, yielding energy in the form of ATP." [GOC:mah]
subset: gosubset_prok
synonym: "glycerol fermentation" EXACT []
is_a: GO:0019563 ! glycerol catabolic process
is_a: GO:0019662 ! non-glycolytic fermentation

[Term]
id: GO:0019589
name: anaerobic glycerol catabolic process to propane-1,3-diol
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol into propane-1,3-diol and water." [GOC:jl, MetaCyc:GOLPDLCAT-PWY]
subset: gosubset_prok
synonym: "glycerol fermentation to 1,3-propanediol" EXACT []
synonym: "glycerol fermentation to propane-1,3-diol" EXACT []
xref: MetaCyc:GOLPDLCAT-PWY
is_a: GO:0019588 ! anaerobic glycerol catabolic process

[Term]
id: GO:0019590
name: L-arabitol catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-arabitol to form xylulose 5-phosphate. L-arabitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate." [MetaCyc:LARABITOLUTIL-PWY]
subset: gosubset_prok
synonym: "L-arabitol and xylitol degradation" BROAD []
synonym: "L-arabitol breakdown to xylulose 5-phosphate" EXACT []
synonym: "L-arabitol degradation to xylulose 5-phosphate" EXACT []
synonym: "L-arabitol utilization" RELATED []
xref: MetaCyc:LARABITOLUTIL-PWY
is_a: GO:0051158 ! L-arabitol catabolic process
is_a: GO:0051167 ! xylulose 5-phosphate metabolic process

[Term]
id: GO:0019591
name: arabitol utilization
namespace: biological_process
subset: gosubset_prok
is_a: GO:0051157 ! arabitol catabolic process

[Term]
id: GO:0019592
name: mannitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "mannitol breakdown" EXACT []
synonym: "mannitol catabolism" EXACT []
synonym: "mannitol degradation" EXACT []
xref: MetaCyc:MANNIDEG-PWY
xref: MetaCyc:PWY-3861
is_a: GO:0019407 ! hexitol catabolic process
is_a: GO:0019594 ! mannitol metabolic process

[Term]
id: GO:0019593
name: mannitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "mannitol anabolism" EXACT []
synonym: "mannitol biosynthesis" EXACT []
synonym: "mannitol formation" EXACT []
synonym: "mannitol synthesis" EXACT []
xref: MetaCyc:PWY-3881
is_a: GO:0019406 ! hexitol biosynthetic process
is_a: GO:0019594 ! mannitol metabolic process

[Term]
id: GO:0019594
name: mannitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "mannitol metabolism" EXACT []
is_a: GO:0006059 ! hexitol metabolic process

[Term]
id: GO:0019595
name: non-phosphorylated glucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of non-phosphorylated forms of glucose." [GOC:ai]
subset: gosubset_prok
synonym: "non-phosphorylated glucose breakdown" EXACT []
synonym: "non-phosphorylated glucose catabolism" EXACT []
synonym: "non-phosphorylated glucose degradation" EXACT []
xref: MetaCyc:NPGLUCAT-PWY
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0046430 ! non-phosphorylated glucose metabolic process

[Term]
id: GO:0019596
name: mandelate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:go_curators]
subset: gosubset_prok
synonym: "mandelate breakdown" EXACT []
synonym: "mandelate catabolism" EXACT []
synonym: "mandelate degradation" EXACT []
is_a: GO:0018924 ! mandelate metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process

[Term]
id: GO:0019597
name: (R)-mandelate catabolic process to benzoate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate." [GOC:go_curators]
subset: gosubset_prok
synonym: "(R)-mandelate breakdown to benzoate" EXACT []
synonym: "(R)-mandelate degradation to benzoate" EXACT []
is_a: GO:0018874 ! benzoate metabolic process
is_a: GO:0019596 ! mandelate catabolic process

[Term]
id: GO:0019598
name: (R)-mandelate catabolic process to catechol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including catechol." [GOC:go_curators]
subset: gosubset_prok
synonym: "(R)-mandelate breakdown to catechol" EXACT []
synonym: "(R)-mandelate degradation to catechol" EXACT []
is_a: GO:0009712 ! catechol metabolic process
is_a: GO:0019596 ! mandelate catabolic process

[Term]
id: GO:0019599
name: (R)-4-hydroxymandelate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of (R)-4-hydroxymandelate, the anion of (R)-4-hydroxymandelic acid." [GOC:ai]
subset: gosubset_prok
synonym: "(R)-4-hydroxymandelate breakdown" EXACT []
synonym: "(R)-4-hydroxymandelate catabolism" EXACT []
synonym: "(R)-4-hydroxymandelate degradation" EXACT []
xref: MetaCyc:4-HYDROXYMANDELATE-DEGRADATION-PWY
is_a: GO:0019596 ! mandelate catabolic process
is_a: GO:0046431 ! (R)-4-hydroxymandelate metabolic process

[Term]
id: GO:0019600
name: toluene oxidation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in toluene." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018970 ! toluene metabolic process

[Term]
id: GO:0019601
name: toluene oxidation via 2-hydroxytoluene
namespace: biological_process
def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 2-hydroxytoluene (o-cresol)." [MetaCyc:TOLUENE-DEG-2-OH-PWY]
subset: gosubset_prok
xref: MetaCyc:TOLUENE-DEG-2-OH-PWY
is_a: GO:0019600 ! toluene oxidation

[Term]
id: GO:0019602
name: toluene oxidation via 3-hydroxytoluene
namespace: biological_process
def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 3-hydroxytoluene (m-cresol)." [MetaCyc:TOLUENE-DEG-3-OH-PWY]
subset: gosubset_prok
xref: MetaCyc:TOLUENE-DEG-3-OH-PWY
is_a: GO:0019600 ! toluene oxidation

[Term]
id: GO:0019603
name: toluene oxidation via 4-hydroxytoluene
namespace: biological_process
def: "The degradation of toluene to form p-hydroxybenzoate; the first step in the pathway is the oxidation of toluene to form 4-hydroxytoluene (4-cresol)." [MetaCyc:TOLUENE-DEG-4-OH-PWY]
subset: gosubset_prok
xref: MetaCyc:TOLUENE-DEG-4-OH-PWY
is_a: GO:0019600 ! toluene oxidation

[Term]
id: GO:0019604
name: toluene oxidation to catechol
namespace: biological_process
def: "The formation from toluene of catechol, dihydroxybenzene, by successive oxidations followed by loss of carbon dioxide (CO2)." [MetaCyc:TOLUENE-DEG-CATECHOL-PWY]
subset: gosubset_prok
xref: MetaCyc:TOLUENE-DEG-CATECHOL-PWY
xref: UM-BBD_pathwayID:tol
is_a: GO:0009712 ! catechol metabolic process
is_a: GO:0019600 ! toluene oxidation

[Term]
id: GO:0019605
name: butyrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "butyrate metabolism" EXACT []
is_a: GO:0046459 ! short-chain fatty acid metabolic process

[Term]
id: GO:0019606
name: 2-oxobutyrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "2-oxobutyrate breakdown" EXACT []
synonym: "2-oxobutyrate catabolism" EXACT []
synonym: "2-oxobutyrate degradation" EXACT []
synonym: "alpha-ketobutyrate catabolic process" EXACT []
synonym: "alpha-ketobutyrate catabolism" EXACT []
xref: MetaCyc:2OXOBUTYRATECAT-PWY
is_a: GO:0046359 ! butyrate catabolic process
is_a: GO:0046361 ! 2-oxobutyrate metabolic process

[Term]
id: GO:0019607
name: phenylethylamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172]
synonym: "phenylethylamine breakdown" EXACT []
synonym: "phenylethylamine catabolism" EXACT []
synonym: "phenylethylamine degradation" EXACT []
xref: MetaCyc:2PHENDEG-PWY
is_a: GO:0042135 ! neurotransmitter catabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
is_a: GO:0042443 ! phenylethylamine metabolic process

[Term]
id: GO:0019608
name: nicotine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684]
subset: gosubset_prok
synonym: "nicotine breakdown" EXACT []
synonym: "nicotine catabolism" EXACT []
synonym: "nicotine degradation" EXACT []
xref: MetaCyc:P181-PWY
xref: UM-BBD_pathwayID:nic
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0018933 ! nicotine metabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0019609
name: 3-hydroxyphenylacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/]
subset: gosubset_prok
synonym: "3-hydroxyphenylacetate metabolism" EXACT []
synonym: "3HPA metabolic process" EXACT []
synonym: "3HPA metabolism" EXACT []
is_a: GO:0018958 ! phenol metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process

[Term]
id: GO:0019610
name: 3-hydroxyphenylacetate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/]
subset: gosubset_prok
synonym: "3-hydroxyphenylacetate breakdown" EXACT []
synonym: "3-hydroxyphenylacetate catabolism" EXACT []
synonym: "3-hydroxyphenylacetate degradation" EXACT []
xref: MetaCyc:3-HYDROXYPHENYLACETATE-DEGRADATION-PWY
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0019609 ! 3-hydroxyphenylacetate metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0019611
name: 4-toluenecarboxylate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai]
subset: gosubset_prok
synonym: "4-toluenecarboxylate metabolism" EXACT []
synonym: "p-toluate metabolic process" EXACT []
synonym: "p-toluate metabolism" EXACT []
is_a: GO:0018970 ! toluene metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0019612
name: 4-toluenecarboxylate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai]
subset: gosubset_prok
synonym: "4-toluenecarboxylate breakdown" EXACT []
synonym: "4-toluenecarboxylate catabolism" EXACT []
synonym: "4-toluenecarboxylate degradation" EXACT []
synonym: "p-toluate catabolic process" EXACT []
synonym: "p-toluate catabolism" EXACT []
xref: MetaCyc:4TOLCARBDEG-PWY
is_a: GO:0019611 ! 4-toluenecarboxylate metabolic process
is_a: GO:0042203 ! toluene catabolic process

[Term]
id: GO:0019614
name: catechol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of catechol, a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators]
subset: gosubset_prok
synonym: "catechol breakdown" EXACT []
synonym: "catechol catabolism" EXACT []
synonym: "catechol degradation" EXACT []
is_a: GO:0009712 ! catechol metabolic process
is_a: GO:0034313 ! diol catabolic process

[Term]
id: GO:0019615
name: catechol catabolic process, ortho-cleavage
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of catechol via the ortho-cleavage pathway, in which the catechol aromatic ring is broken between the two carbon atoms bearing hydroxyl groups." [GOC:jl, http://www.ence.umd.edu/]
subset: gosubset_prok
synonym: "catechol breakdown, ortho-cleavage" EXACT []
synonym: "catechol degradation, ortho-cleavage" EXACT []
xref: MetaCyc:CATECHOL-ORTHO-CLEAVAGE-PWY
is_a: GO:0019614 ! catechol catabolic process
is_a: GO:0042952 ! beta-ketoadipate pathway

[Term]
id: GO:0019616
name: catechol catabolic process, meta-cleavage
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of catechol via the meta-cleavage pathway, in which the catechol aromatic ring is broken between a hydroxylated carbon atom and an adjacent unsubstituted carbon atom." [GOC:jl, http://www.ence.umd.edu/]
subset: gosubset_prok
synonym: "catechol breakdown, meta-cleavage" EXACT []
synonym: "catechol degradation, meta-cleavage" EXACT []
xref: MetaCyc:P183-PWY
is_a: GO:0019614 ! catechol catabolic process

[Term]
id: GO:0019617
name: protocatechuate catabolic process, meta-cleavage
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield oxaloacetate and pyruvate." [MetaCyc:P184-PWY]
subset: gosubset_prok
synonym: "protocatechuate breakdown, meta-cleavage" EXACT []
synonym: "protocatechuate degradation, meta-cleavage" EXACT []
xref: MetaCyc:P184-PWY
is_a: GO:0019619 ! protocatechuate catabolic process

[Term]
id: GO:0019618
name: protocatechuate catabolic process, ortho-cleavage
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield beta-ketoadipate." [MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY]
subset: gosubset_prok
synonym: "protocatechuate breakdown, ortho-cleavage" EXACT []
synonym: "protocatechuate degradation, ortho-cleavage" EXACT []
xref: MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY
is_a: GO:0019619 ! protocatechuate catabolic process

[Term]
id: GO:0019619
name: protocatechuate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "protocatechuate breakdown" EXACT []
synonym: "protocatechuate catabolism" EXACT []
synonym: "protocatechuate degradation" EXACT []
is_a: GO:0019614 ! catechol catabolic process
is_a: GO:0046278 ! protocatechuate metabolic process

[Term]
id: GO:0019620
name: aerobic benzoate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the presence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "aerobic benzoate metabolism" EXACT []
is_a: GO:0018874 ! benzoate metabolic process

[Term]
id: GO:0019621
name: creatinine catabolic process to formate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of creatinine into other compounds, including formate." [GOC:go_curators]
subset: gosubset_prok
synonym: "creatinine breakdown to formate" EXACT []
synonym: "creatinine degradation to formate" EXACT []
xref: MetaCyc:CRNFORCAT-PWY
is_a: GO:0006602 ! creatinine catabolic process
is_a: GO:0015942 ! formate metabolic process

[Term]
id: GO:0019622
name: 3-(3-hydroxy)phenylpropionate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate." [GOC:ai]
subset: gosubset_prok
synonym: "3-(3-hydroxy)phenylpropionate breakdown" EXACT []
synonym: "3-(3-hydroxy)phenylpropionate catabolism" EXACT []
synonym: "3-(3-hydroxy)phenylpropionate degradation" EXACT []
xref: MetaCyc:HCAMHPDEG-PWY
is_a: GO:0019380 ! 3-phenylpropionate catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0046435 ! 3-(3-hydroxy)phenylpropionate metabolic process

[Term]
id: GO:0019623
name: atrazine catabolic process to urea
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into urea." [GOC:jl]
subset: gosubset_prok
synonym: "atrazine breakdown to urea" EXACT []
synonym: "atrazine degradation to urea" EXACT []
is_a: GO:0019381 ! atrazine catabolic process
is_a: GO:0019627 ! urea metabolic process

[Term]
id: GO:0019624
name: atrazine catabolic process to isopropylamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into isopropylamine." [GOC:jl]
subset: gosubset_prok
synonym: "atrazine breakdown to isopropylamine" EXACT []
synonym: "atrazine degradation to isopropylamine" EXACT []
is_a: GO:0019381 ! atrazine catabolic process

[Term]
id: GO:0019625
name: atrazine catabolic process to cyanuric acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into cyanuric acid." [GOC:jl]
subset: gosubset_prok
synonym: "atrazine breakdown to cyanuric acid" EXACT []
synonym: "atrazine degradation to cyanuric acid" EXACT []
xref: MetaCyc:P141-PWY
is_a: GO:0019381 ! atrazine catabolic process
is_a: GO:0042199 ! cyanuric acid metabolic process

[Term]
id: GO:0019626
name: short-chain fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than 8 carbons." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "short-chain fatty acid breakdown" EXACT []
synonym: "short-chain fatty acid catabolism" EXACT []
synonym: "short-chain fatty acid degradation" EXACT []
xref: MetaCyc:ACETOACETATE-DEG-PWY
is_a: GO:0009062 ! fatty acid catabolic process
is_a: GO:0046459 ! short-chain fatty acid metabolic process

[Term]
id: GO:0019627
name: urea metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2, produced in the liver by the ornithine cycle. It is the main nitrogen-containing excretion product in ureotelic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "urea metabolism" EXACT []
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0019628
name: urate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "urate breakdown" EXACT []
synonym: "urate catabolism" EXACT []
synonym: "urate degradation" EXACT []
synonym: "uric acid catabolic process" EXACT []
xref: MetaCyc:P165-PWY
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0046415 ! urate metabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0019629
name: propionate catabolic process, 2-methylcitrate cycle
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle." [GOC:go_curators]
subset: gosubset_prok
synonym: "propionate breakdown, 2-methylcitrate cycle" EXACT []
synonym: "propionate degradation, 2-methylcitrate cycle" EXACT []
is_a: GO:0019543 ! propionate catabolic process

[Term]
id: GO:0019630
name: quinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving quinate, the anion of quinic acid. The acid occurs commonly in plants, either free or as esters, and is used as a medicine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "quinate metabolism" EXACT []
synonym: "quinic acid metabolic process" EXACT []
synonym: "quinic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0019631
name: quinate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of quinate, the anion of quinic acid." [GOC:jl]
subset: gosubset_prok
synonym: "quinate breakdown" EXACT []
synonym: "quinate catabolism" EXACT []
synonym: "quinate degradation" EXACT []
synonym: "quinic acid catabolic process" EXACT []
synonym: "quinic acid catabolism" EXACT []
xref: MetaCyc:QUINATEDEG-PWY
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0019630 ! quinate metabolic process

[Term]
id: GO:0019632
name: shikimate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids." [ChEBI:36208, GOC:sm, ISBN:0198547684]
subset: gosubset_prok
synonym: "shikimate metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0019633
name: shikimate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid." [ChEBI:36208, GOC:go_curators]
subset: gosubset_prok
synonym: "shikimate breakdown" EXACT []
synonym: "shikimate catabolism" EXACT []
synonym: "shikimate degradation" EXACT []
xref: MetaCyc:SHIKIMATEDEG-PWY
is_a: GO:0019632 ! shikimate metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0019634
name: phosphonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "phosphonate metabolism" EXACT []
is_a: GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0019635
name: 2-aminoethylphosphonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-aminoethylphosphonate, also known as ciliatine." [GOC:ai]
subset: gosubset_prok
synonym: "2-aminoethylphosphonate breakdown" EXACT []
synonym: "2-aminoethylphosphonate catabolism" EXACT []
synonym: "2-aminoethylphosphonate degradation" EXACT []
synonym: "2-phosphonoethylamine catabolic process" EXACT []
synonym: "2-phosphonoethylamine catabolism" EXACT []
synonym: "ciliatine catabolic process" EXACT []
synonym: "ciliatine catabolism" EXACT []
xref: MetaCyc:PHOSPHONOTASE-PWY
is_a: GO:0019700 ! phosphonate catabolic process
is_a: GO:0046433 ! 2-aminoethylphosphonate metabolic process

[Term]
id: GO:0019636
name: phosphonoacetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphonoacetate, C2H4PO5, a substance composed of an acetate and a phosphonic acid residue." [MetaCyc:P483-PWY]
subset: gosubset_prok
synonym: "phosphonoacetate metabolism" EXACT []
xref: MetaCyc:P483-PWY
is_a: GO:0019634 ! phosphonate metabolic process

[Term]
id: GO:0019637
name: organophosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "organophosphate metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0019638
name: 6-hydroxycineole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai]
subset: gosubset_prok
synonym: "6-endo-hydroxycineole metabolic process" EXACT []
synonym: "6-endo-hydroxycineole metabolism" EXACT []
synonym: "6-hydroxycineole metabolism" EXACT []
synonym: "hydroxycineol metabolic process" EXACT []
synonym: "hydroxycineol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:0018904 ! organic ether metabolic process

[Term]
id: GO:0019639
name: 6-hydroxycineole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai]
subset: gosubset_prok
synonym: "6-endo-hydroxycineole catabolic process" EXACT []
synonym: "6-endo-hydroxycineole catabolism" EXACT []
synonym: "6-hydroxycineole breakdown" EXACT []
synonym: "6-hydroxycineole catabolism" EXACT []
synonym: "6-hydroxycineole degradation" EXACT []
synonym: "hydroxycineol catabolic process" EXACT []
synonym: "hydroxycineol catabolism" EXACT []
xref: MetaCyc:6-HYDROXYCINEOLE-DEGRADATION-PWY
is_a: GO:0019638 ! 6-hydroxycineole metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0019640
name: glucuronate catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "glucuronate breakdown to xylulose 5-phosphate" EXACT []
synonym: "glucuronate degradation to xylulose 5-phosphate" EXACT []
is_a: GO:0006064 ! glucuronate catabolic process
is_a: GO:0051167 ! xylulose 5-phosphate metabolic process

[Term]
id: GO:0019643
name: reductive tricarboxylic acid cycle
namespace: biological_process
alt_id: GO:0019644
def: "A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate." [GOC:jl, PMID:15838028]
subset: gosubset_prok
synonym: "reductive carboxylate cycle" EXACT []
synonym: "reductive carboxylic acid cycle" EXACT []
synonym: "reductive citric acid pathway" EXACT []
synonym: "reductive Kreb's cycle" EXACT []
synonym: "reductive TCA cycle" EXACT []
xref: MetaCyc:P23-PWY
xref: MetaCyc:REDCITCYC
is_a: GO:0006099 ! tricarboxylic acid cycle
is_a: GO:0015977 ! carbon utilization by fixation of carbon dioxide

[Term]
id: GO:0019645
name: anaerobic electron transport chain
namespace: biological_process
def: "A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors other than oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0009061 ! anaerobic respiration

[Term]
id: GO:0019646
name: aerobic electron transport chain
namespace: biological_process
alt_id: GO:0006136
alt_id: GO:0006137
alt_id: GO:0006138
def: "A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "NADH-O2 electron transport" NARROW []
synonym: "succinate-O2 electron transport" NARROW []
synonym: "ubiquinone-8-O2 electron transport" NARROW []
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0022904 ! respiratory electron transport chain

[Term]
id: GO:0019647
name: formaldehyde assimilation via ribulose monophosphate cycle
namespace: biological_process
def: "The pathway in which formaldehyde is used as a carbon source in the ribulose monophosphate cycle. Methanotrophic bacteria produce formaldehyde from the oxidation of methane and methanol, and then assimilate it via the ribulose monophosphate cycle to form intermediates of the central metabolic routes that are subsequently used for biosynthesis of cell material. Three molecules of formaldehyde are assimilated, forming a three-carbon intermediate of central metabolism; in this pathway, all cellular carbon is assimilated at the oxidation level of formaldehyde." [MetaCyc:PWY-1861]
subset: gosubset_prok
synonym: "formaldehyde assimilation via RuMP cycle" EXACT []
synonym: "ribulose monophosphate cycle" BROAD []
xref: MetaCyc:PWY-1861
is_a: GO:0019649 ! formaldehyde assimilation

[Term]
id: GO:0019648
name: formaldehyde assimilation via xylulose monophosphate cycle
namespace: biological_process
def: "The pathway in which formaldehyde is used as a carbon source in the xylulose monophosphate cycle. Methylotrophic yeasts, but not bacteria, utilize the xylulose monophosphate cycle to fix formaldehyde and convert it into metabolically useful organic compounds." [MetaCyc:P185-PWY]
subset: gosubset_prok
synonym: "formaldehyde assimilation via xylulose-5-phosphate cycle" EXACT []
synonym: "formaldehyde fixation cycle" EXACT []
xref: MetaCyc:P185-PWY
is_a: GO:0019649 ! formaldehyde assimilation
is_a: GO:0051167 ! xylulose 5-phosphate metabolic process

[Term]
id: GO:0019649
name: formaldehyde assimilation
namespace: biological_process
def: "The pathways in which formaldehyde is processed and used as a carbon source for the cell." [GOC:ai]
subset: gosubset_prok
is_a: GO:0046292 ! formaldehyde metabolic process

[Term]
id: GO:0019650
name: glucose catabolic process to butanediol
namespace: biological_process
alt_id: GO:0030646
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into 2,3-butanediol and other substances; effected by some members of the Enterobacteriaceae, e.g. Enterobacter, Erwinia, Klebsiella, and Serratia." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "butanediol fermentation" EXACT []
synonym: "glucose fermentation to butanediol" EXACT []
xref: MetaCyc:P125-PWY
xref: Wikipedia:Butanediol_fermentation
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0019660 ! glycolytic fermentation
is_a: GO:0034077 ! butanediol metabolic process

[Term]
id: GO:0019651
name: citrate catabolic process to diacetyl
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of citrate to diacetyl, yielding energy in the form of ATP." [MetaCyc:P126-PWY]
subset: gosubset_prok
synonym: "citrate fermentation to diacetyl" EXACT []
synonym: "diacetyl fermentation" EXACT []
is_a: GO:0019662 ! non-glycolytic fermentation

[Term]
id: GO:0019652
name: lactate fermentation to propionate and acetate
namespace: biological_process
def: "The anaerobic enzymatic conversion of lactate to propionate, concomitant with the oxidation of lactate to acetate and CO2 and yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl, MetaCyc:PROPFERM-PWY]
subset: gosubset_prok
synonym: "acrylate pathway" EXACT []
synonym: "nonrandomizing pathway" EXACT []
synonym: "propionate fermentation" EXACT []
xref: MetaCyc:PROPFERM-PWY
is_a: GO:0019541 ! propionate metabolic process
is_a: GO:0019660 ! glycolytic fermentation

[Term]
id: GO:0019653
name: anaerobic purine catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of purines, yielding energy in the form of ATP." [GOC:mah]
subset: gosubset_prok
synonym: "purine fermentation" EXACT []
xref: MetaCyc:P164-PWY
xref: MetaCyc:PWY-5044
xref: MetaCyc:PWY-5497
is_a: GO:0006145 ! purine base catabolic process
is_a: GO:0019666 ! nitrogenous compound catabolic process

[Term]
id: GO:0019654
name: acetate fermentation
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate, yielding energy in the form of ATP." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
xref: MetaCyc:P142-PWY
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0019655
name: glucose catabolic process to ethanol
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose." [ISBN:0716720094]
subset: gosubset_prok
synonym: "ethanol fermentation" EXACT []
synonym: "glucose fermentation to ethanol" EXACT []
xref: Wikipedia:Ethanol_fermentation
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0006067 ! ethanol metabolic process
is_a: GO:0019660 ! glycolytic fermentation

[Term]
id: GO:0019656
name: glucose catabolic process to D-lactate and ethanol
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the enzymatic breakdown of D-glucose to D-lactate and ethanol, yielding energy in the form of adenosine triphosphate (ATP) at the rate of one ATP per glucose molecule." [GOC:jl, MetaCyc:P122-PWY]
subset: gosubset_prok
synonym: "glucose fermentation to D-lactate and ethanol" EXACT []
synonym: "heterofermentation" EXACT []
synonym: "heterofermentative lactate fermentation" EXACT []
synonym: "heterofermentative pathway" EXACT []
synonym: "heterolactate fermentation" EXACT []
synonym: "heterolactic fermentation" EXACT []
xref: MetaCyc:P122-PWY
is_a: GO:0019659 ! glucose catabolic process to lactate
is_a: GO:0019662 ! non-glycolytic fermentation

[Term]
id: GO:0019657
name: pyruvate fermentation to propionate
namespace: biological_process
def: "The anaerobic conversion of pyruvate to propionate, yielding energy in the form of ATP; an alternative to the acrylate pathway to produce propionate." [MetaCyc:P108-PWY]
subset: gosubset_prok
synonym: "succinate-propionate fermentation" EXACT []
xref: MetaCyc:P108-PWY
is_a: GO:0006105 ! succinate metabolic process
is_a: GO:0019541 ! propionate metabolic process
is_a: GO:0019660 ! glycolytic fermentation

[Term]
id: GO:0019658
name: glucose catabolic process to lactate and acetate
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose to lactate and acetate, yielding energy in the form of ATP." [MetaCyc:P124-PWY]
subset: gosubset_prok
synonym: "bifidum pathway" EXACT []
synonym: "glucose fermentation to lactate and acetate" EXACT []
xref: MetaCyc:P124-PWY
is_a: GO:0019659 ! glucose catabolic process to lactate
is_a: GO:0019662 ! non-glycolytic fermentation

[Term]
id: GO:0019659
name: glucose catabolic process to lactate
namespace: biological_process
def: "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, and possibly ethanol, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl]
subset: gosubset_prok
synonym: "glucose fermentation to lactate" EXACT []
synonym: "lactate fermentation" EXACT []
xref: Wikipedia:Lactic_acid_fermentation
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0006089 ! lactate metabolic process
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0019660
name: glycolytic fermentation
namespace: biological_process
def: "Fermentation that includes the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0006006 ! glucose metabolic process
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0019661
name: glucose catabolic process to lactate via pyruvate
namespace: biological_process
def: "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via pyruvate, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl, http://dwb.unl.edu/]
subset: gosubset_prok
synonym: "glucose fermentation to lactate via pyruvate" EXACT []
synonym: "homofermentation" EXACT []
synonym: "homofermentative lactate fermentation" EXACT []
synonym: "homofermentative pathway" EXACT []
synonym: "homolactate fermentation" EXACT []
synonym: "homolactic fermentation" EXACT []
is_a: GO:0019659 ! glucose catabolic process to lactate
is_a: GO:0019660 ! glycolytic fermentation

[Term]
id: GO:0019662
name: non-glycolytic fermentation
namespace: biological_process
def: "Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0019663
name: homoacetate catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of homoacetate, yielding energy in the form of ATP." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "homoacetate fermentation" EXACT []
is_a: GO:0019654 ! acetate fermentation
is_a: GO:0019660 ! glycolytic fermentation

[Term]
id: GO:0019664
name: glucose catabolic process to mixed acids
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP." [MetaCyc:FERMENTATION-PWY]
subset: gosubset_prok
synonym: "glucose fermentation to mixed acids" EXACT []
synonym: "mixed acid fermentation" EXACT []
xref: Wikipedia:Mixed_acid_fermentation
is_a: GO:0019660 ! glycolytic fermentation

[Term]
id: GO:0019665
name: anaerobic amino acid catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "amino acid fermentation" EXACT []
is_a: GO:0006113 ! fermentation
is_a: GO:0009063 ! cellular amino acid catabolic process

[Term]
id: GO:0019666
name: nitrogenous compound catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of a nitrogen-containing compound, yielding energy in the form of ATP." [GOC:mah]
subset: gosubset_prok
synonym: "nitrogenous compound fermentation" EXACT []
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0019667
name: anaerobic L-alanine catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of L-alanine, yielding energy in the form of ATP." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "L-alanine fermentation" EXACT []
is_a: GO:0019665 ! anaerobic amino acid catabolic process
is_a: GO:0042853 ! L-alanine catabolic process

[Term]
id: GO:0019668
name: anaerobic catabolic process of pairs of amino acids
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids; in these reactions, one amino acid is oxidised (acts as an electron donor) and a different amino acid is reduced (acts as an electron acceptor); oxidation of the electron-donating amino acid yields energy in the form of ATP." [GOC:mah, PMID:13140081]
subset: gosubset_prok
synonym: "cofermentation of pairs of amino acids" EXACT []
synonym: "Stickland reaction" NARROW []
is_a: GO:0019665 ! anaerobic amino acid catabolic process

[Term]
id: GO:0019669
name: anaerobic glycine catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycine, yielding energy in the form of ATP." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "glycine fermentation" EXACT []
is_a: GO:0006546 ! glycine catabolic process
is_a: GO:0019665 ! anaerobic amino acid catabolic process

[Term]
id: GO:0019670
name: anaerobic glutamate catabolic process
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, yielding energy in the form of ATP." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "glutamate fermentation" EXACT []
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0019665 ! anaerobic amino acid catabolic process

[Term]
id: GO:0019671
name: glutamate catabolic process via mesaconate and citramalate
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate via the intermediates mesaconate and S-citramalate, yielding energy in the form of ATP." [MetaCyc:GLUDEG-II-PWY]
subset: gosubset_prok
synonym: "glutamate fermentation via mesaconate and citramalate" EXACT []
xref: MetaCyc:GLUDEG-II-PWY
is_a: GO:0019670 ! anaerobic glutamate catabolic process

[Term]
id: GO:0019672
name: ethanol-acetate fermentation to butyrate and caproate
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of ethanol and acetate to butyrate and caproate, yielding energy in the form of ATP." [MetaCyc:P127-PWY]
subset: gosubset_prok
is_a: GO:0019662 ! non-glycolytic fermentation

[Term]
id: GO:0019673
name: GDP-mannose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP-mannose metabolism" EXACT []
is_a: GO:0006013 ! mannose metabolic process
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0019674
name: NAD metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]
subset: gosubset_prok
synonym: "NAD (oxidized) metabolic process" EXACT []
synonym: "NAD (oxidized) metabolism" EXACT []
synonym: "NAD metabolism" EXACT []
synonym: "NAD phosphorylation and dephosphorylation" NARROW []
synonym: "nicotinamide adenine dinucleotide metabolic process" EXACT []
synonym: "nicotinamide adenine dinucleotide metabolism" EXACT []
synonym: "oxidized NAD metabolic process" EXACT []
synonym: "oxidized NAD metabolism" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide metabolic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide metabolism" EXACT []
xref: Reactome:196807 "Nicotinate metabolism"
xref: Reactome:448584 "Nicotinate metabolism"
xref: Reactome:469713 "Nicotinate metabolism"
xref: Reactome:487425 "Nicotinate metabolism"
xref: Reactome:507381 "Nicotinate metabolism"
xref: Reactome:517407 "Nicotinate metabolism"
xref: Reactome:526258 "Nicotinate metabolism"
xref: Reactome:531131 "Nicotinate metabolism"
xref: Reactome:536505 "Nicotinate metabolism"
xref: Reactome:542217 "Nicotinate metabolism"
xref: Reactome:547673 "Nicotinate metabolism"
xref: Reactome:552179 "Nicotinate metabolism"
xref: Reactome:557781 "Nicotinate metabolism"
xref: Reactome:568394 "Nicotinate metabolism"
xref: Reactome:581596 "Nicotinate metabolism"
xref: Reactome:585988 "Nicotinate metabolism"
xref: Reactome:592473 "Nicotinate metabolism"
xref: Reactome:595343 "Nicotinate metabolism"
xref: Reactome:597315 "Nicotinate metabolism"
xref: Reactome:598115 "Nicotinate metabolism"
xref: Reactome:599663 "Nicotinate metabolism"
xref: Reactome:600588 "Nicotinate metabolism"
xref: Reactome:602476 "Nicotinate metabolism"
is_a: GO:0006769 ! nicotinamide metabolic process
is_a: GO:0046496 ! nicotinamide nucleotide metabolic process

[Term]
id: GO:0019675
name: NAD phosphorylation and dephosphorylation
namespace: biological_process
def: "OBSOLETE. The addition or removal of a phosphate group from nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153]
comment: This term was made obsolete because it represents a process, NAD dephosphorylation, that does not exist.
synonym: "nicotinamide adenine dinucleotide phosphorylation and dephosphorylation" EXACT []
is_obsolete: true
consider: GO:0006739
consider: GO:0019674

[Term]
id: GO:0019676
name: ammonia assimilation cycle
namespace: biological_process
def: "The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen." [MetaCyc:AMMASSIM-PWY]
subset: gosubset_prok
synonym: "glutamate metabolic process via glutamine and ammonia" EXACT []
synonym: "glutamate metabolism via glutamine and ammonia" EXACT []
xref: MetaCyc:AMMASSIM-PWY
xref: MetaCyc:PWY-3282
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0006541 ! glutamine metabolic process

[Term]
id: GO:0019677
name: NAD catabolic process
namespace: biological_process
alt_id: GO:0006737
def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153]
subset: gosubset_prok
synonym: "NAD (oxidized) catabolic process" EXACT []
synonym: "NAD (oxidized) catabolism" EXACT []
synonym: "NAD (reduced) catabolic process" EXACT []
synonym: "NAD (reduced) catabolism" EXACT []
synonym: "NAD breakdown" EXACT []
synonym: "NAD catabolism" EXACT []
synonym: "NAD degradation" EXACT []
synonym: "NADH catabolic process" EXACT []
synonym: "NADH catabolism" EXACT []
synonym: "nicotinamide adenine dinucleotide catabolic process" EXACT []
synonym: "nicotinamide adenine dinucleotide catabolism" EXACT []
synonym: "oxidized NAD catabolic process" EXACT []
synonym: "oxidized NAD catabolism" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide catabolic process" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide catabolism" EXACT []
synonym: "reduced NAD catabolic process" EXACT []
synonym: "reduced NAD catabolism" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide catabolic process" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide catabolism" EXACT []
is_a: GO:0019364 ! pyridine nucleotide catabolic process
is_a: GO:0019674 ! NAD metabolic process

[Term]
id: GO:0019678
name: propionate metabolic process, methylmalonyl pathway
namespace: biological_process
def: "The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway." [GOC:go_curators]
subset: gosubset_prok
synonym: "propionate metabolism, methylmalonyl pathway" EXACT []
xref: MetaCyc:PROPIONMET-PWY
is_a: GO:0019541 ! propionate metabolic process

[Term]
id: GO:0019679
name: propionate metabolic process, methylcitrate cycle
namespace: biological_process
def: "The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle." [GOC:go_curators]
subset: gosubset_prok
synonym: "propionate metabolism, methylcitrate cycle" EXACT []
xref: MetaCyc:PWY0-42
is_a: GO:0019541 ! propionate metabolic process

[Term]
id: GO:0019680
name: L-methylmalonyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA." [GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-methylmalonyl-CoA anabolism" EXACT []
synonym: "L-methylmalonyl-CoA biosynthesis" EXACT []
synonym: "L-methylmalonyl-CoA formation" EXACT []
synonym: "L-methylmalonyl-CoA synthesis" EXACT []
xref: MetaCyc:PWY0-43
is_a: GO:0006104 ! succinyl-CoA metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0046491 ! L-methylmalonyl-CoA metabolic process

[Term]
id: GO:0019681
name: acetyl-CoA assimilation pathway
namespace: biological_process
def: "The pathways by which acetyl-CoA is processed and converted into alpha-ketoglutarate (2-oxoglutarate); methanogenic archaea use these pathways to assimilate acetyl-CoA into the cell." [MetaCyc:P22-PWY]
subset: gosubset_prok
synonym: "acetyl-CoA catabolic process to 2-ketoglutarate" EXACT []
synonym: "acetyl-CoA catabolic process to 2-oxoglutarate" EXACT []
synonym: "acetyl-CoA catabolic process to alpha-ketoglutarate" EXACT []
synonym: "acetyl-CoA catabolic process to alpha-oxoglutarate" EXACT []
synonym: "acetyl-CoA catabolism to 2-ketoglutarate" EXACT []
synonym: "acetyl-CoA catabolism to 2-oxoglutarate" EXACT []
synonym: "acetyl-CoA catabolism to alpha-ketoglutarate" EXACT []
synonym: "acetyl-CoA catabolism to alpha-oxoglutarate" EXACT []
is_a: GO:0006103 ! 2-oxoglutarate metabolic process
is_a: GO:0046356 ! acetyl-CoA catabolic process

[Term]
id: GO:0019682
name: glyceraldehyde-3-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glyceraldehyde 3-phosphate metabolic process" EXACT []
synonym: "glyceraldehyde 3-phosphate metabolism" EXACT []
synonym: "glyceraldehyde-3-phosphate metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:0019683
name: glyceraldehyde-3-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glyceraldehyde 3-phosphate catabolic process" EXACT []
synonym: "glyceraldehyde 3-phosphate catabolism" EXACT []
synonym: "glyceraldehyde-3-phosphate breakdown" EXACT []
synonym: "glyceraldehyde-3-phosphate catabolism" EXACT []
synonym: "glyceraldehyde-3-phosphate degradation" EXACT []
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:0046365 ! monosaccharide catabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0019684
name: photosynthesis, light reaction
namespace: biological_process
def: "The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I." [http://www.arabidopsis.org]
synonym: "photolysis" EXACT []
xref: MetaCyc:PWY-101
xref: Wikipedia:Photolysis#Photolysis_in_photosynthesis
is_a: GO:0006091 ! generation of precursor metabolites and energy
relationship: part_of GO:0015979 ! photosynthesis

[Term]
id: GO:0019685
name: photosynthesis, dark reaction
namespace: biological_process
def: "A complex cycle of enzyme-mediated reactions which catalyzes the reduction of carbon dioxide to sugar. As well as carbon dioxide the cycle requires reducing power in the form of reduced nicotinamide adenine dinucleotide phosphate (NADP) and chemical energy in the form of adenosine triphosphate (ATP). The reduced NADP (NADPH) and ATP are produced by the 'light' reactions." [ISBN:0582015952]
is_a: GO:0016051 ! carbohydrate biosynthetic process
relationship: part_of GO:0015979 ! photosynthesis

[Term]
id: GO:0019686
name: purine nucleoside interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a purine nucleoside is synthesized from another purine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0015949 ! nucleobase, nucleoside and nucleotide interconversion

[Term]
id: GO:0019687
name: pyruvate biosynthetic process from acetate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyruvate from other compounds, including acetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "pyruvate anabolism from acetate" EXACT []
synonym: "pyruvate formation from acetate" EXACT []
synonym: "pyruvate synthesis from acetate" EXACT []
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0042866 ! pyruvate biosynthetic process

[Term]
id: GO:0019688
name: purine deoxyribonucleoside interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a purine deoxyribonucleoside is synthesized from another purine deoxyribonucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0019686 ! purine nucleoside interconversion

[Term]
id: GO:0019689
name: pyrimidine nucleoside interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a pyrimidine nucleoside is synthesized from another pyrimidine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0015949 ! nucleobase, nucleoside and nucleotide interconversion

[Term]
id: GO:0019690
name: pyrimidine deoxyribonucleoside interconversion
namespace: biological_process
def: "The chemical reactions and pathways by which a pyrimidine deoxyribonucleoside is synthesized from another deoxyribopyrimidine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831]
subset: gosubset_prok
is_a: GO:0019689 ! pyrimidine nucleoside interconversion

[Term]
id: GO:0019691
name: UDP-glucose conversion
namespace: biological_process
subset: gosubset_prok
is_a: GO:0006011 ! UDP-glucose metabolic process
is_a: GO:0009227 ! nucleotide-sugar catabolic process

[Term]
id: GO:0019692
name: deoxyribose phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "deoxyribose phosphate metabolism" EXACT []
is_a: GO:0006014 ! D-ribose metabolic process

[Term]
id: GO:0019693
name: ribose phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai]
subset: gosubset_prok
synonym: "ribose phosphate metabolism" EXACT []
is_a: GO:0006014 ! D-ribose metabolic process

[Term]
id: GO:0019694
name: alkanesulfonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon moiety." [GOC:ai]
subset: gosubset_prok
synonym: "alkanesulfonate metabolism" EXACT []
synonym: "alkanesulphonate metabolic process" EXACT []
synonym: "alkanesulphonate metabolism" EXACT []
xref: MetaCyc:ALKANEMONOX-PWY
is_a: GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0019695
name: choline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "choline metabolism" EXACT []
is_a: GO:0042439 ! ethanolamine and derivative metabolic process

[Term]
id: GO:0019696
name: toluene oxidation via toluene-cis-1,2-dihydrodiol
namespace: biological_process
def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form toluene-cis-1,2-dihydrodiol." [MetaCyc:TOLUENE-DEG-DIOL-PWY]
subset: gosubset_prok
xref: MetaCyc:TOLUENE-DEG-DIOL-PWY
is_a: GO:0019600 ! toluene oxidation

[Term]
id: GO:0019697
name: L-xylitol catabolic process to xylulose 5-phosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-xylitol to form xylulose 5-phosphate. L-xylitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate." [MetaCyc:LARABITOLUTIL-PWY]
subset: gosubset_prok
synonym: "L-arabitol and xylitol degradation" BROAD []
synonym: "L-xylitol breakdown to xylulose 5-phosphate" EXACT []
synonym: "L-xylitol degradation to xylulose 5-phosphate" EXACT []
synonym: "L-xylitol utilization" RELATED []
xref: MetaCyc:LARABITOLUTIL-PWY
is_a: GO:0051160 ! L-xylitol catabolic process
is_a: GO:0051167 ! xylulose 5-phosphate metabolic process

[Term]
id: GO:0019698
name: D-galacturonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid." [GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-galacturonate breakdown" EXACT []
synonym: "D-galacturonate catabolism" EXACT []
synonym: "D-galacturonate degradation" EXACT []
xref: MetaCyc:GALACTUROCAT-PWY
is_a: GO:0046396 ! D-galacturonate metabolic process
is_a: GO:0046397 ! galacturonate catabolic process

[Term]
id: GO:0019700
name: phosphonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js]
subset: gosubset_prok
synonym: "phosphonate breakdown" EXACT []
synonym: "phosphonate catabolism" EXACT []
synonym: "phosphonate degradation" EXACT []
is_a: GO:0019634 ! phosphonate metabolic process
is_a: GO:0046434 ! organophosphate catabolic process

[Term]
id: GO:0019701
name: peptidyl-arginine N5-methylation
namespace: biological_process
def: "The methylation of peptidyl-arginine on the internal nitrogen-5 (N5) atom (also called delta-nitrogen) to form peptidyl-N5-methyl-L-arginine." [GOC:bf, PMID:9792625, RESID:AA0305]
subset: gosubset_prok
synonym: "peptidyl-arginine delta-N-methylation" EXACT []
xref: RESID:AA0305
is_a: GO:0035246 ! peptidyl-arginine N-methylation

[Term]
id: GO:0019702
name: protein-arginine N5-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues." [PMID:9873020]
synonym: "protein-arginine delta-N-methyltransferase activity" EXACT []
synonym: "type IV PRMT activity" EXACT []
synonym: "type IV protein arginine methyltransferase activity" EXACT []
xref: EC:2.1.1.-
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity

[Term]
id: GO:0019703
name: coenzyme A-peptidyl-cysteine covalent linking
namespace: biological_process
def: "The covalent linkage of coenzyme A and peptidyl-cysteine to form L-cysteine coenzyme A disulfide." [RESID:AA0306]
subset: gosubset_prok
xref: RESID:AA0306
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0019704
name: peptidyl-S-myristoyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The posttranslational modification of peptidyl-cysteine to form peptidyl-S-myristoyl-L-cysteine." [RESID:AA0307]
subset: gosubset_prok
synonym: "peptidyl-S-myristoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-myristoyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-myristoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0307
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018319 ! protein amino acid myristoylation

[Term]
id: GO:0019705
name: protein-cysteine S-myristoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an myristoyl group to a sulfur atom on the cysteine of a protein molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0019107 ! myristoyltransferase activity
is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity

[Term]
id: GO:0019706
name: protein-cysteine S-palmitoleyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a palmitoleyl group to a sulfur atom on the cysteine of a protein molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0016409 ! palmitoyltransferase activity
is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity

[Term]
id: GO:0019707
name: protein-cysteine S-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule." [GOC:ai]
xref: EC:2.3.1.-
is_a: GO:0016417 ! S-acyltransferase activity

[Term]
id: GO:0019708
name: peptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine
namespace: biological_process
def: "The synthesis of peptidyl-glycine cholest-5-en-3-beta-ol ester at the carboxy-terminus of autolytically cleaved proteins." [RESID:AA0309]
subset: gosubset_prok
synonym: "peptidyl-glycine cholesteryl ester anabolism from peptidyl-glycine" EXACT []
synonym: "peptidyl-glycine cholesteryl ester formation from peptidyl-glycine" EXACT []
synonym: "peptidyl-glycine cholesteryl ester synthesis from peptidyl-glycine" EXACT []
xref: RESID:AA0309
is_a: GO:0006501 ! C-terminal protein lipidation
is_a: GO:0008203 ! cholesterol metabolic process
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0019709
name: iron incorporation into iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide
namespace: biological_process
def: "The incorporation of iron into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." [RESID:AA0310]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide" EXACT []
xref: RESID:AA0310
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0019710
name: peptidyl-asparagine methylation
namespace: biological_process
alt_id: GO:0018018
def: "The methylation of peptidyl-asparagine to form peptidyl-N4-methyl-L-asparagine or peptidyl-N4,N4-dimethyl-L-asparagine." [RESID:AA0070, RESID:AA0311]
subset: gosubset_prok
xref: RESID:AA0070
xref: RESID:AA0311
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0019711
name: peptidyl-beta-carboxyaspartic acid biosynthetic process from peptidyl-aspartic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptidyl-beta-carboxyaspartic acid from other compounds, including peptidyl-aspartic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "peptidyl-beta-carboxyaspartic acid anabolism from peptidyl-aspartic acid" EXACT []
synonym: "peptidyl-beta-carboxyaspartic acid formation from peptidyl-aspartic acid" EXACT []
synonym: "peptidyl-beta-carboxyaspartic acid synthesis from peptidyl-aspartic acid" EXACT []
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0019712
name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamic acid
namespace: biological_process
def: "The methyl esterification of peptidyl-glutamic acid." [RESID:AA0072]
subset: gosubset_prok
synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamic acid" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from glutamic acid" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamic acid" EXACT []
xref: RESID:AA0072
is_a: GO:0018390 ! peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine

[Term]
id: GO:0019713
name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamine
namespace: biological_process
def: "The coupled methyl esterification and deamidation of peptidyl-glutamine." [RESID:AA0072]
subset: gosubset_prok
synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamine" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from glutamine" EXACT []
synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamine" EXACT []
xref: RESID:AA0072
is_a: GO:0006541 ! glutamine metabolic process
is_a: GO:0018390 ! peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine
is_a: GO:0019714 ! peptidyl-glutamine esterification

[Term]
id: GO:0019714
name: peptidyl-glutamine esterification
namespace: biological_process
def: "The addition of an ester group to a glutamine residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018199 ! peptidyl-glutamine modification
is_a: GO:0018350 ! protein amino acid esterification

[Term]
id: GO:0019715
name: peptidyl-aspartic acid hydroxylation to form L-erythro-beta-hydroxyaspartic acid
namespace: biological_process
def: "The posttranslational hydroxylation of peptidyl-aspartic acid to form peptidyl-L-erythro-beta-hydroxyaspartic acid; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0027]
comment: See also the molecular function term 'peptide-aspartate beta-dioxygenase activity ; GO:0004597'.
subset: gosubset_prok
xref: RESID:AA0027
is_a: GO:0042264 ! peptidyl-aspartic acid hydroxylation

[Term]
id: GO:0019716
name: N-terminal peptidyl-alanine monomethylation
namespace: biological_process
def: "The monomethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N-methyl-L-alanine." [RESID:AA0061]
subset: gosubset_prok
xref: RESID:AA0061
is_a: GO:0018011 ! N-terminal peptidyl-alanine methylation

[Term]
id: GO:0019717
name: synaptosome
namespace: cellular_component
def: "Any of the discrete particles (nerve-ending particles) formed from the clublike presynaptic nerve endings that resist disruption and are snapped or torn off their attachments when brain tissue is homogenized in media isosmotic to plasma." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
xref: Wikipedia:Synaptosome
is_a: GO:0005624 ! membrane fraction

[Term]
id: GO:0019718
name: rough microsome
namespace: cellular_component
def: "Vesicular particles formed from disrupted endoplasmic reticulum membranes and studded with ribosomes on the outside." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
is_a: GO:0005792 ! microsome

[Term]
id: GO:0019719
name: smooth microsome
namespace: cellular_component
def: "Vesicular particles formed from disrupted endoplasmic reticulum and plasma membranes without any adhering ribosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
is_a: GO:0005792 ! microsome

[Term]
id: GO:0019720
name: Mo-molybdopterin cofactor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257]
subset: gosubset_prok
synonym: "Mo-molybdopterin cofactor metabolism" EXACT []
synonym: "Moco metabolic process" BROAD []
synonym: "Moco metabolism" BROAD []
is_a: GO:0043545 ! molybdopterin cofactor metabolic process

[Term]
id: GO:0019722
name: calcium-mediated signaling
namespace: biological_process
def: "A series of molecular signals in which a cell uses calcium ions to convert an extracellular signal into a response." [GOC:ceb]
synonym: "calcium signaling" EXACT []
synonym: "calcium signalling" EXACT []
synonym: "calcium-mediated signalling" EXACT []
xref: Wikipedia:Calcium_signaling
is_a: GO:0019932 ! second-messenger-mediated signaling

[Term]
id: GO:0019724
name: B cell mediated immunity
namespace: biological_process
def: "Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was improved by GO_REF:0000022. It was moved.
synonym: "B lymphocyte mediated immune effector process" EXACT []
synonym: "B lymphocyte mediated immunity" EXACT []
synonym: "B-cell mediated immune effector process" EXACT []
synonym: "B-cell mediated immunity" EXACT []
synonym: "B-lymphocyte mediated immune effector process" EXACT []
synonym: "B-lymphocyte mediated immunity" EXACT []
is_a: GO:0002449 ! lymphocyte mediated immunity
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0019725
name: cellular homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172]
subset: goslim_candida
subset: goslim_generic
subset: goslim_plant
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
is_a: GO:0009987 ! cellular process
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0019726
name: mevaldate reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-mevalonate + NADP+ = mevaldate + NADPH + H+." [EC:1.1.1.33]
synonym: "(R)-mevalonate:NADP+ oxidoreductase" EXACT [EC:1.1.1.33]
synonym: "mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase" EXACT [EC:1.1.1.33]
xref: EC:1.1.1.33
xref: MetaCyc:MEVALDATE-REDUCTASE-NADPH-RXN
is_a: GO:0004495 ! mevaldate reductase activity

[Term]
id: GO:0019727
name: mevaldate reductase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-mevalonate + NAD+ = mevaldate + NADH + H+." [EC:1.1.1.32]
xref: EC:1.1.1.32
xref: MetaCyc:MEVALDATE-REDUCTASE-RXN
is_a: GO:0004495 ! mevaldate reductase activity

[Term]
id: GO:0019728
name: peptidyl-allysine oxidation to 2-aminoadipic acid
namespace: biological_process
def: "The oxidation of allysine to 2-aminoadipic acid." [RESID:AA0122]
subset: gosubset_prok
xref: RESID:AA0370
is_a: GO:0018158 ! protein amino acid oxidation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0019729
name: peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine
namespace: biological_process
def: "The formation of the fluorescent protein FP583 chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0189]
comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'.
subset: gosubset_prok
synonym: "biosynthesis of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine" EXACT []
xref: RESID:AA0189
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018199 ! peptidyl-glutamine modification
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0019730
name: antimicrobial humoral response
namespace: biological_process
alt_id: GO:0006960
alt_id: GO:0019735
def: "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0006959 ! humoral immune response
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0019731
name: antibacterial humoral response
namespace: biological_process
alt_id: GO:0006961
alt_id: GO:0019733
def: "An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0019730 ! antimicrobial humoral response
is_a: GO:0042742 ! defense response to bacterium

[Term]
id: GO:0019732
name: antifungal humoral response
namespace: biological_process
alt_id: GO:0006966
alt_id: GO:0019734
def: "An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0019730 ! antimicrobial humoral response
is_a: GO:0050832 ! defense response to fungus

[Term]
id: GO:0019736
name: peptidyl-sarcosine incorporation
namespace: biological_process
def: "The incorporation of sarcosine (N-methylglycine) into non-coded peptides." [RESID:AA0063]
subset: gosubset_prok
xref: RESID:AA0063
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0019740
name: nitrogen utilization
namespace: biological_process
subset: gosubset_prok
is_a: GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0019741
name: pentacyclic triterpenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pentacyclic triterpenoid breakdown" EXACT []
synonym: "pentacyclic triterpenoid catabolism" EXACT []
synonym: "pentacyclic triterpenoid degradation" EXACT []
is_a: GO:0016105 ! triterpenoid catabolic process
is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process

[Term]
id: GO:0019742
name: pentacyclic triterpenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pentacyclic triterpenoid metabolism" EXACT []
is_a: GO:0006722 ! triterpenoid metabolic process

[Term]
id: GO:0019743
name: hopanoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684]
subset: gosubset_prok
synonym: "hopanoid breakdown" EXACT []
synonym: "hopanoid catabolism" EXACT []
synonym: "hopanoid degradation" EXACT []
is_a: GO:0019741 ! pentacyclic triterpenoid catabolic process
is_a: GO:0019744 ! hopanoid metabolic process

[Term]
id: GO:0019744
name: hopanoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684]
subset: gosubset_prok
synonym: "hopanoid metabolism" EXACT []
is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process

[Term]
id: GO:0019745
name: pentacyclic triterpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pentacyclic triterpenoid anabolism" EXACT []
synonym: "pentacyclic triterpenoid biosynthesis" EXACT []
synonym: "pentacyclic triterpenoid formation" EXACT []
synonym: "pentacyclic triterpenoid synthesis" EXACT []
is_a: GO:0016104 ! triterpenoid biosynthetic process
is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process

[Term]
id: GO:0019746
name: hopanoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684]
subset: gosubset_prok
synonym: "hopanoid anabolism" EXACT []
synonym: "hopanoid biosynthesis" EXACT []
synonym: "hopanoid formation" EXACT []
synonym: "hopanoid synthesis" EXACT []
is_a: GO:0019744 ! hopanoid metabolic process
is_a: GO:0019745 ! pentacyclic triterpenoid biosynthetic process

[Term]
id: GO:0019747
name: regulation of isoprenoid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of isoprenoid metabolism" EXACT []
is_a: GO:0019216 ! regulation of lipid metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
relationship: regulates GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0019748
name: secondary metabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "secondary metabolism" EXACT []
xref: Wikipedia:Secondary_metabolism
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0019749
name: cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte
namespace: biological_process
def: "The directed movement of substances along cytoskeletal elements, such as microfilaments or microtubules, from a nurse cell to an oocyte." [GOC:ai]
is_a: GO:0007303 ! cytoplasmic transport, nurse cell to oocyte
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport

[Term]
id: GO:0019750
name: chloroplast transport
namespace: biological_process
def: "The directed movement of a chloroplast, a chlorophyll-containing plastid found in cells of algae and higher plants, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0006810 ! transport

[Term]
id: GO:0019751
name: polyol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [ChEBI:26191, GOC:go_curators]
subset: gosubset_prok
synonym: "polyhydric alcohol metabolic process" EXACT []
synonym: "polyol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process

[Term]
id: GO:0019752
name: carboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "carboxylic acid metabolism" EXACT []
is_a: GO:0043436 ! oxoacid metabolic process

[Term]
id: GO:0019755
name: one-carbon compound transport
namespace: biological_process
def: "The directed movement of one-carbon compounds into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
synonym: "one carbon compound transport" EXACT []
is_a: GO:0006810 ! transport

[Term]
id: GO:0019756
name: cyanogenic glycoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cyanogenic glycoside anabolism" EXACT []
synonym: "cyanogenic glycoside biosynthesis" EXACT []
synonym: "cyanogenic glycoside formation" EXACT []
synonym: "cyanogenic glycoside synthesis" EXACT []
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0042341 ! cyanogenic glycoside metabolic process

[Term]
id: GO:0019757
name: glycosinolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html]
subset: gosubset_prok
synonym: "glycosinolate metabolism" EXACT []
is_a: GO:0016143 ! S-glycoside metabolic process
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:0019758
name: glycosinolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html]
subset: gosubset_prok
synonym: "glycosinolate anabolism" EXACT []
synonym: "glycosinolate biosynthesis" EXACT []
synonym: "glycosinolate formation" EXACT []
synonym: "glycosinolate synthesis" EXACT []
is_a: GO:0016144 ! S-glycoside biosynthetic process
is_a: GO:0019757 ! glycosinolate metabolic process

[Term]
id: GO:0019759
name: glycosinolate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html]
subset: gosubset_prok
synonym: "glycosinolate breakdown" EXACT []
synonym: "glycosinolate catabolism" EXACT []
synonym: "glycosinolate degradation" EXACT []
is_a: GO:0016145 ! S-glycoside catabolic process
is_a: GO:0019757 ! glycosinolate metabolic process

[Term]
id: GO:0019760
name: glucosinolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "glucosinolate metabolism" EXACT []
is_a: GO:0019757 ! glycosinolate metabolic process

[Term]
id: GO:0019761
name: glucosinolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [GOC:ai]
subset: gosubset_prok
synonym: "glucosinolate anabolism" EXACT []
synonym: "glucosinolate biosynthesis" EXACT []
synonym: "glucosinolate formation" EXACT []
synonym: "glucosinolate synthesis" EXACT []
is_a: GO:0019758 ! glycosinolate biosynthetic process
is_a: GO:0019760 ! glucosinolate metabolic process

[Term]
id: GO:0019762
name: glucosinolate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [GOC:ai]
subset: gosubset_prok
synonym: "glucosinolate breakdown" EXACT []
synonym: "glucosinolate catabolism" EXACT []
synonym: "glucosinolate degradation" EXACT []
xref: MetaCyc:PWY-5267
is_a: GO:0019759 ! glycosinolate catabolic process
is_a: GO:0019760 ! glucosinolate metabolic process

[Term]
id: GO:0019763
name: immunoglobulin receptor activity
namespace: molecular_function
alt_id: GO:0016489
def: "Combining with the Fc region of an immunoglobulin protein to initiate a change in cell activity." [ISBN:0198547684]
synonym: "FC receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane receptor activity
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0019764
name: high affinity Fc receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:add]
comment: This term was made obsolete because it is an unnecessary grouping term.
is_obsolete: true
consider: GO:0019768
consider: GO:0019771

[Term]
id: GO:0019765
name: low affinity Fc receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:add]
comment: This term was made obsolete because it is undefined and is an unnecessary grouping term.
is_obsolete: true
consider: GO:0019769
consider: GO:0019772

[Term]
id: GO:0019766
name: IgA receptor activity
namespace: molecular_function
def: "Combining with an immunoglobulin of an IgA isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0019763 ! immunoglobulin receptor activity
is_a: GO:0019862 ! IgA binding

[Term]
id: GO:0019767
name: IgE receptor activity
namespace: molecular_function
def: "Combining with an immunoglobulin of the IgE isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0019763 ! immunoglobulin receptor activity
is_a: GO:0019863 ! IgE binding

[Term]
id: GO:0019768
name: high affinity IgE receptor activity
namespace: molecular_function
def: "Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "high affinity Fc receptor activity" RELATED []
is_a: GO:0019767 ! IgE receptor activity

[Term]
id: GO:0019769
name: low affinity IgE receptor activity
namespace: molecular_function
def: "Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "low affinity Fc receptor activity" RELATED []
is_a: GO:0019767 ! IgE receptor activity

[Term]
id: GO:0019770
name: IgG receptor activity
namespace: molecular_function
def: "Combining with an immunoglobulin of an IgG isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0019763 ! immunoglobulin receptor activity
is_a: GO:0019864 ! IgG binding

[Term]
id: GO:0019771
name: high affinity IgG receptor activity
namespace: molecular_function
def: "Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "high affinity Fc receptor activity" RELATED []
is_a: GO:0019770 ! IgG receptor activity

[Term]
id: GO:0019772
name: low affinity IgG receptor activity
namespace: molecular_function
def: "Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "low affinity Fc receptor activity" RELATED []
is_a: GO:0019770 ! IgG receptor activity

[Term]
id: GO:0019773
name: proteasome core complex, alpha-subunit complex
namespace: cellular_component
def: "The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:proteasome, GOC:rb, PMID:10854779]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0005839 ! proteasome core complex

[Term]
id: GO:0019774
name: proteasome core complex, beta-subunit complex
namespace: cellular_component
def: "The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:proteasome, GOC:rb, PMID:10854779]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0005839 ! proteasome core complex

[Term]
id: GO:0019775
name: FAT10 ligase activity
namespace: molecular_function
def: "Catalysis of the covalent attachment of the ubiquitin-like protein FAT10 to other proteins." [GOC:mah, PMID:12826404]
synonym: "FAT10 conjugating enzyme activity" RELATED []
is_a: GO:0019787 ! small conjugating protein ligase activity

[Term]
id: GO:0019776
name: Atg8 ligase activity
namespace: molecular_function
def: "Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 to substrate molecules; phosphatidylethanolamine is a known substrate." [GOC:mah, PMID:12826404]
synonym: "APG8 conjugating enzyme activity" EXACT []
synonym: "APG8 ligase activity" EXACT []
synonym: "Atg8 conjugating enzyme activity" EXACT []
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0019777
name: Atg12 ligase activity
namespace: molecular_function
def: "Catalysis of the covalent attachment of the ubiquitin-like protein Atg12 to other proteins." [GOC:mah, PMID:12826404]
synonym: "APG12 conjugating enzyme activity" EXACT []
synonym: "APG12 ligase activity" EXACT []
synonym: "Atg12 conjugating enzyme activity" RELATED []
is_a: GO:0019787 ! small conjugating protein ligase activity

[Term]
id: GO:0019778
name: APG12 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0019779
name: APG8 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
synonym: "APG7" EXACT []
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0019780
name: FAT10 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0019781
name: NEDD8 activating enzyme activity
namespace: molecular_function
alt_id: GO:0019944
def: "Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade." [PMID:12646924]
synonym: "RUB1 activating enzyme activity" EXACT []
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0019782
name: ISG15 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
synonym: "UBE1L" NARROW []
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0019783
name: small conjugating protein-specific protease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated." [GOC:ma, GOC:mah]
subset: gosubset_prok
synonym: "ubiquitin-like specific protease activity" NARROW []
synonym: "ubiquitin-like-protein-specific protease activity" NARROW []
is_a: GO:0008234 ! cysteine-type peptidase activity

[Term]
id: GO:0019784
name: NEDD8-specific protease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates." [GOC:mah]
is_a: GO:0019783 ! small conjugating protein-specific protease activity

[Term]
id: GO:0019785
name: ISG15-specific protease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of ISG15, a small ubiquitin-related modifier, from previously modified substrates." [GOC:mah]
is_a: GO:0019783 ! small conjugating protein-specific protease activity

[Term]
id: GO:0019786
name: APG8-specific protease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier." [GOC:mah]
synonym: "APG8-PE hydrolase" RELATED []
is_a: GO:0019783 ! small conjugating protein-specific protease activity

[Term]
id: GO:0019787
name: small conjugating protein ligase activity
namespace: molecular_function
alt_id: GO:0008639
alt_id: GO:0008640
def: "Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686]
subset: gosubset_prok
synonym: "E2" NARROW []
synonym: "small protein conjugating enzyme activity" EXACT []
synonym: "ubiquitin-like conjugating enzyme activity" NARROW []
synonym: "ubiquitin-like-protein ligase activity" NARROW []
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0019788
name: NEDD8 ligase activity
namespace: molecular_function
alt_id: GO:0016976
alt_id: GO:0019945
alt_id: GO:0042295
def: "Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue." [GOC:mah]
synonym: "Hub1 conjugating enzyme activity" EXACT []
synonym: "NEDD8 conjugating enzyme activity" EXACT []
synonym: "RUB1 conjugating enzyme activity" EXACT []
is_a: GO:0019787 ! small conjugating protein ligase activity

[Term]
id: GO:0019789
name: SUMO ligase activity
namespace: molecular_function
alt_id: GO:0016930
alt_id: GO:0019949
def: "Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal glycine residues of the small ubiquitin-related modifier SUMO and a substrate lysine residue, leading to the formation of predominately monosumoylated proteins with modified function." [GOC:rn, PMID:11031248, PMID:11265250]
synonym: "SMT3 conjugating enzyme" EXACT []
synonym: "SUMO conjugating enzyme activity" EXACT []
is_a: GO:0019787 ! small conjugating protein ligase activity

[Term]
id: GO:0019790
name: ubiquitin-like hydrolase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature.
is_obsolete: true
consider: GO:0019783

[Term]
id: GO:0019791
name: FAT10 hydrolase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature.
is_obsolete: true
consider: GO:0019783

[Term]
id: GO:0019792
name: APG12 hydrolase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature.
is_obsolete: true
consider: GO:0019783

[Term]
id: GO:0019793
name: ISG15 carrier activity
namespace: molecular_function
def: "Catalysis of the transfer of ISG15 (interferon-stimulated gene-15) from one side of the membrane to the other." [GOC:jl, http://www.copewithcytokines.de/]
synonym: "interferon-stimulated gene-15 carrier activity" NARROW []
is_a: GO:0008320 ! protein transmembrane transporter activity

[Term]
id: GO:0019794
name: nonprotein amino acid metabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways involving any amino acid not found, or rarely found, in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity.
subset: gosubset_prok
synonym: "nonprotein amino acid metabolism" EXACT []
is_obsolete: true
replaced_by: GO:0006520

[Term]
id: GO:0019795
name: nonprotein amino acid biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of any amino acid that does not normally occur as a constituent residue of proteins." [GOC:ma]
comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity.
subset: gosubset_prok
synonym: "nonprotein amino acid anabolism" EXACT []
synonym: "nonprotein amino acid biosynthesis" EXACT []
synonym: "nonprotein amino acid formation" EXACT []
synonym: "nonprotein amino acid synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0008652

[Term]
id: GO:0019796
name: nonprotein amino acid catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of any amino acid not found, or rarely found, in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity.
subset: gosubset_prok
synonym: "nonprotein amino acid breakdown" EXACT []
synonym: "nonprotein amino acid catabolism" EXACT []
synonym: "nonprotein amino acid degradation" EXACT []
is_obsolete: true
replaced_by: GO:0009063

[Term]
id: GO:0019797
name: procollagen-proline 3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.7]
synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.7]
synonym: "procollagen-proline,2-oxoglutarate 3-dioxygenase activity" EXACT [EC:1.14.11.7]
synonym: "proline,2-oxoglutarate 3-dioxygenase activity" EXACT [EC:1.14.11.7]
synonym: "prolyl 3-hydroxylase activity" EXACT [EC:1.14.11.7]
synonym: "prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity" EXACT [EC:1.14.11.7]
synonym: "protocollagen proline 3-hydroxylase activity" EXACT [EC:1.14.11.7]
xref: EC:1.14.11.7
xref: MetaCyc:PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN
is_a: GO:0019798 ! procollagen-proline dioxygenase activity
is_a: GO:0031544 ! peptidyl-proline 3-dioxygenase activity

[Term]
id: GO:0019798
name: procollagen-proline dioxygenase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a collagen molecule." [EC:1.14.11.2, EC:1.14.11.7, GOC:mah]
xref: EC:1.14.11.-
is_a: GO:0031543 ! peptidyl-proline dioxygenase activity

[Term]
id: GO:0019799
name: tubulin N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine." [EC:2.3.1.108]
synonym: "acetyl-CoA:alpha-tubulin-L-lysine 6-N-acetyltransferase activity" EXACT [EC:2.3.1.108]
synonym: "acetyl-CoA:alpha-tubulin-L-lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.108]
synonym: "acetyl-CoA:alpha-tubulin-lysine N-acetyltransferase activity" EXACT [EC:2.3.1.108]
synonym: "alpha-tubulin acetylase activity" EXACT [EC:2.3.1.108]
synonym: "alpha-tubulin acetyltransferase activity" EXACT [EC:2.3.1.108]
synonym: "alpha-tubulin N-acetyltransferase activity" EXACT [EC:2.3.1.108]
synonym: "TAT activity" EXACT [EC:2.3.1.108]
synonym: "tubulin acetyltransferase activity" EXACT [EC:2.3.1.108]
xref: EC:2.3.1.108
xref: MetaCyc:TUBULIN-N-ACETYLTRANSFERASE-RXN
is_a: GO:0034212 ! peptide N-acetyltransferase activity

[Term]
id: GO:0019800
name: peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
namespace: biological_process
def: "The formation of a cross-link between peptide chains mediated by a chondroitin 4-sulfate glycosaminoglycan that originates from a typical O-glycosidic link to serine of one chain; the other chain is esterified, via the alpha-carbon of its C-terminal Asp, to C-6 of an internal N-acetylgalactosamine of the glycosaminoglycan chain." [PMID:1898736, RESID:AA0219]
subset: gosubset_prok
synonym: "peptide cross-linking via chondroitin 4-sulphate glycosaminoglycan" EXACT []
xref: RESID:AA0219
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0030204 ! chondroitin sulfate metabolic process

[Term]
id: GO:0019801
name: cyclization of asparagine, during protein splicing
namespace: biological_process
def: "The cyclization of asparagine to yield an L-aspartimide (otherwise known as alpha-aminosuccinimide) residue at the C-terminus of an excised intein during protein splicing." [RESID:AA0302]
comment: See also the biological process term 'intein-mediated protein splicing ; GO:0016539'.
subset: gosubset_prok
xref: RESID:AA0302
is_a: GO:0006528 ! asparagine metabolic process
relationship: part_of GO:0016539 ! intein-mediated protein splicing

[Term]
id: GO:0019802
name: cyclization of glutamine, during protein splicing
namespace: biological_process
def: "The cyclization of glutamine to yield an L-glutamimide residue at the C-terminus of an excised intein during protein splicing." [RESID:AA0303]
comment: Note that this term should not be confused with 'peptidyl-pyroglutamic acid biosynthesis, using glutaminyl-peptide cyclotransferase ; GO:0017186'. See also the biological process term 'intein-mediated protein splicing ; GO:0016539'.
subset: gosubset_prok
xref: RESID:AA0303
is_a: GO:0006541 ! glutamine metabolic process
relationship: part_of GO:0016539 ! intein-mediated protein splicing

[Term]
id: GO:0019803
name: peptidyl-aspartic acid carboxylation
namespace: biological_process
def: "The carboxylation of peptidyl-aspartic acid to form peptidyl-L-beta-carboxyaspartic acid." [RESID:AA0304]
subset: gosubset_prok
xref: RESID:AA0304
is_a: GO:0018197 ! peptidyl-aspartic acid modification
is_a: GO:0018214 ! protein amino acid carboxylation

[Term]
id: GO:0019804
name: quinolinate synthetase complex
namespace: cellular_component
def: "OBSOLETE. A heterodimer which acts as a quinolinate synthetase; quinolinate synthetase B (L-aspartate oxidase) catalyzes the oxidation of L-aspartate to L-iminoaspartate; quinolinate synthetase A condenses L-imidoaspartate and dihydroxyacetone to quinolinate." [UniProtKB:P10902]
comment: This term was made obsolete because there is no evidence that a physical complex forms; although the phrase "quinolinate synthetase complex" is occasionally used in the literature, it refers to two enzymes that act as monomers.
is_obsolete: true
consider: GO:0008743
consider: GO:0008987

[Term]
id: GO:0019805
name: quinolinate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai]
subset: gosubset_prok
synonym: "quinolinate anabolism" EXACT []
synonym: "quinolinate biosynthesis" EXACT []
synonym: "quinolinate formation" EXACT []
synonym: "quinolinate synthesis" EXACT []
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0046874 ! quinolinate metabolic process

[Term]
id: GO:0019806
name: bromide peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 R-H + 2 bromide + H2O2 = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide." [EC:1.11.1.10]
subset: gosubset_prok
synonym: "bromoperoxidase activity" EXACT []
xref: EC:1.11.1.-
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0019807
name: aspartoacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate." [EC:3.5.1.15]
subset: gosubset_prok
synonym: "acetyl-aspartic deaminase activity" EXACT [EC:3.5.1.15]
synonym: "acylase II" RELATED [EC:3.5.1.15]
synonym: "aminoacylase II activity" RELATED [EC:3.5.1.15]
synonym: "N-acetylaspartate amidohydrolase activity" EXACT [EC:3.5.1.15]
synonym: "N-acyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.15]
xref: EC:3.5.1.15
xref: MetaCyc:ASPARTOACYLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0019808
name: polyamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with polyamines, organic compounds containing two or more amino groups." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043176 ! amine binding

[Term]
id: GO:0019809
name: spermidine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai]
is_a: GO:0019808 ! polyamine binding

[Term]
id: GO:0019810
name: putrescine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai]
is_a: GO:0019808 ! polyamine binding

[Term]
id: GO:0019811
name: cocaine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0008144 ! drug binding

[Term]
id: GO:0019812
name: Type I site-specific deoxyribonuclease complex
namespace: cellular_component
def: "A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995, PMID:15788748]
subset: gosubset_prok
synonym: "Type I restriction enzyme complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0019813
name: Type III site-specific deoxyribonuclease complex
namespace: cellular_component
def: "A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995]
subset: gosubset_prok
synonym: "Type III restriction enzyme complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0019814
name: immunoglobulin complex
namespace: cellular_component
def: "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, GOC:jl, ISBN:0781765196]
comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
subset: goslim_pir
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0019815
name: B cell receptor complex
namespace: cellular_component
alt_id: GO:0042570
def: "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "antibody" RELATED [GOC:mah]
synonym: "B cell receptor accessory molecule complex" RELATED []
synonym: "B lymphocyte receptor complex" EXACT []
synonym: "B-cell receptor complex" EXACT []
synonym: "B-lymphocyte receptor complex" EXACT []
synonym: "BCR complex" EXACT []
synonym: "immunoglobulin complex, membrane bound" EXACT []
is_a: GO:0019814 ! immunoglobulin complex
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0019816
name: B cell receptor accessory molecule complex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it represents a molecule and not a location or complex.
is_obsolete: true
consider: GO:0019815

[Term]
id: GO:0019817
name: vesicle fusion with peroxisome
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the peroxisome." [GOC:jic]
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0007031 ! peroxisome organization

[Term]
id: GO:0019819
name: P1 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019820
name: P2 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019821
name: P3 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P3 peroxisomes are formed by fusion of P1 and P2 peroxisomes, and are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019822
name: P4 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019823
name: P5 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P6 peroxisome ; GO:0019824'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019824
name: P6 peroxisome
namespace: cellular_component
def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes." [PMID:10629216]
comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P5 peroxisome ; GO:0019823'.
synonym: "peroxisome vesicle" BROAD []
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0019825
name: oxygen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with oxygen (O2)." [GOC:jl]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "cytochrome P450" NARROW []
synonym: "cytochrome P450 activity" RELATED []
xref: Reactome:4477 "oxygen binding"
is_a: GO:0005488 ! binding

[Term]
id: GO:0019826
name: oxygen sensor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2)." [GOC:mah]
is_a: GO:0019825 ! oxygen binding

[Term]
id: GO:0019827
name: stem cell maintenance
namespace: biological_process
def: "The process by which an organism retains a population of stem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:mah, ISBN:0878932437]
is_a: GO:0032502 ! developmental process
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: part_of GO:0048864 ! stem cell development

[Term]
id: GO:0019828
name: aspartic-type endopeptidase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process." [GOC:ai]
synonym: "aspartic protease inhibitor activity" EXACT []
is_a: GO:0004866 ! endopeptidase inhibitor activity

[Term]
id: GO:0019829
name: cation-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "cation ABC transporter" NARROW []
synonym: "plasma membrane cation-transporting ATPase" NARROW []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0042625 ! ATPase activity, coupled to transmembrane movement of ions

[Term]
id: GO:0019830
name: cadmium sensitivity/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046686

[Term]
id: GO:0019831
name: chromate sensitivity/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046687

[Term]
id: GO:0019832
name: mercuric sensitivity/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046689

[Term]
id: GO:0019833
name: ice nucleation activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees C) to protect the organism from damage by intracellular ice formation. Ice nucleation proteins function by binding an ice crystal and then encouraging it to form larger crystals. Ice nucleation is a chemical process but these proteins can positively regulate it. There are two different uses of ice nucleation proteins: bacteria secrete them extracellularly to cause a host organism's cells to freeze and die, and fish use them to protect themselves from intracellular ice formation." [GOC:ai, GOC:jl]
comment: This term was made obsolete because it represents a biological process.
is_obsolete: true
replaced_by: GO:0009405
replaced_by: GO:0042309
replaced_by: GO:0050825

[Term]
id: GO:0019834
name: phospholipase A2 inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of the enzyme phospholipase A2." [GOC:ai]
is_a: GO:0004859 ! phospholipase inhibitor activity

[Term]
id: GO:0019835
name: cytolysis
namespace: biological_process
def: "The rupture of cell membranes and the loss of cytoplasm." [SP_KW:KW-0204]
subset: gosubset_prok
synonym: "autolysin activity" RELATED []
synonym: "bacteriocin activity" RELATED []
synonym: "bacteriolytic toxin activity" RELATED []
synonym: "holin" RELATED []
synonym: "lysin activity" RELATED []
synonym: "lysis" BROAD []
synonym: "necrosis" RELATED []
xref: Wikipedia:Cytolysis
is_a: GO:0008219 ! cell death

[Term]
id: GO:0019836
name: hemolysis by symbiont of host erythrocytes
namespace: biological_process
def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in the host organism by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, SP_KW:KW-0354]
subset: gosubset_prok
synonym: "haemolysis in host" EXACT []
synonym: "hemolysin activity" RELATED []
synonym: "hemolysis by symbiont of host RBCs" EXACT [CL:0000232]
synonym: "hemolysis by symbiont of host red blood cells" EXACT [CL:0000232]
synonym: "regulation of cytolysis of host cells by symbiont" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001897 ! cytolysis by symbiont of host cells
is_a: GO:0052331 ! hemolysis of cells in other organism during symbiotic interaction

[Term]
id: GO:0019837
name: herbicide susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0009635

[Term]
id: GO:0019838
name: growth factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:jl, http://cancerweb.ncl.ac.uk/]
synonym: "neurotrophin TRK receptor activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0019840
name: isoprenoid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0019841
name: retinol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation." [http://cancerweb.ncl.ac.uk/]
synonym: "vitamin A1 alcohol binding" EXACT []
synonym: "vitamin A1 binding" EXACT []
is_a: GO:0005501 ! retinoid binding
is_a: GO:0019842 ! vitamin binding

[Term]
id: GO:0019842
name: vitamin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0019843
name: rRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl]
subset: gosubset_prok
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0019844
name: endotoxin activity
namespace: molecular_function
def: "OBSOLETE. The function of any microbial toxin that cannot be easily separated from the structure of the cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
consider: GO:0005622
consider: GO:0009405
consider: GO:0050827

[Term]
id: GO:0019845
name: exotoxin activity
namespace: molecular_function
def: "OBSOLETE. The function of a toxin formed by a microorganism and secreted into the surrounding medium." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
consider: GO:0005576
consider: GO:0009405
consider: GO:0050827

[Term]
id: GO:0019846
name: enterotoxin activity
namespace: molecular_function
def: "OBSOLETE. Acts as to cause injury to the intestinal mucosa of other living organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
consider: GO:0009405
consider: GO:0050827

[Term]
id: GO:0019847
name: neurotoxin activity
namespace: molecular_function
def: "OBSOLETE. Acts to inhibit neural function in another living organism." [GOC:jl, http://cancerweb.ncl.ac.uk/]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
consider: GO:0009405
consider: GO:0050827

[Term]
id: GO:0019848
name: conotoxin activity
namespace: molecular_function
def: "OBSOLETE. Acts to inhibit neural function in another organism by inhibiting voltage-gated calcium ion channels and neurotransmitter release. This function is thought to be specific to the venom of two marine snail species." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0019855
consider: GO:0046929

[Term]
id: GO:0019849
name: cytotoxin activity
namespace: molecular_function
def: "OBSOLETE. Acts as to cause injury to other living cells." [GOC:jl, http://cancerweb.ncl.ac.uk/]
comment: This term was made obsolete because it represents a class of gene products.
is_obsolete: true
consider: GO:0009405
consider: GO:0050827

[Term]
id: GO:0019852
name: L-ascorbic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [ChEBI:38290, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ascorbate metabolic process" EXACT []
synonym: "ascorbate metabolism" EXACT []
synonym: "L-ascorbic acid metabolism" EXACT []
synonym: "vitamin C metabolic process" EXACT []
synonym: "vitamin C metabolism" EXACT []
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0019853
name: L-ascorbic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [ChEBI:38290, GOC:ma, ISBN:0198547684]
subset: gosubset_prok
synonym: "ascorbate biosynthesis" EXACT []
synonym: "ascorbate biosynthetic process" EXACT []
synonym: "L-ascorbic acid anabolism" EXACT []
synonym: "L-ascorbic acid biosynthesis" EXACT []
synonym: "L-ascorbic acid formation" EXACT []
synonym: "L-ascorbic acid synthesis" EXACT []
synonym: "vitamin C biosynthesis" EXACT []
synonym: "vitamin C biosynthetic process" EXACT []
xref: MetaCyc:PWY-882
is_a: GO:0019852 ! L-ascorbic acid metabolic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0019854
name: L-ascorbic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [ChEBI:38290, GOC:go_curators]
subset: gosubset_prok
synonym: "ascorbate catabolic process" EXACT []
synonym: "ascorbate catabolism" EXACT []
synonym: "L-ascorbic acid breakdown" EXACT []
synonym: "L-ascorbic acid catabolism" EXACT []
synonym: "L-ascorbic acid degradation" EXACT []
synonym: "vitamin C catabolic process" EXACT []
synonym: "vitamin C catabolism" EXACT []
xref: MetaCyc:PWY0-301
is_a: GO:0019852 ! L-ascorbic acid metabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0019855
name: calcium channel inhibitor activity
namespace: molecular_function
def: "Stops, prevents, or reduces the activity of a calcium channel." [GOC:mah]
is_a: GO:0005246 ! calcium channel regulator activity
is_a: GO:0008200 ! ion channel inhibitor activity

[Term]
id: GO:0019856
name: pyrimidine base biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators]
subset: gosubset_prok
synonym: "pyrimidine base anabolism" EXACT []
synonym: "pyrimidine base biosynthesis" EXACT []
synonym: "pyrimidine base formation" EXACT []
synonym: "pyrimidine base synthesis" EXACT []
is_a: GO:0006206 ! pyrimidine base metabolic process
is_a: GO:0046112 ! nucleobase biosynthetic process

[Term]
id: GO:0019857
name: 5-methylcytosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 5-methylcytosine, a methylated base of DNA." [GOC:ai]
subset: gosubset_prok
synonym: "5-methylcytosine metabolism" EXACT []
is_a: GO:0006206 ! pyrimidine base metabolic process

[Term]
id: GO:0019858
name: cytosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:ai]
subset: gosubset_prok
synonym: "cytosine metabolism" EXACT []
is_a: GO:0006206 ! pyrimidine base metabolic process

[Term]
id: GO:0019859
name: thymine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators]
subset: gosubset_prok
synonym: "thymine metabolism" EXACT []
is_a: GO:0006206 ! pyrimidine base metabolic process

[Term]
id: GO:0019860
name: uracil metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "uracil metabolism" EXACT []
is_a: GO:0006206 ! pyrimidine base metabolic process

[Term]
id: GO:0019861
name: flagellum
namespace: cellular_component
alt_id: GO:0008223
def: "Long whiplike or feathery structures borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [SP_KW:KW-0282]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Flagellum
is_a: GO:0042995 ! cell projection
is_a: GO:0043229 ! intracellular organelle

[Term]
id: GO:0019862
name: IgA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an immunoglobulin of an IgA isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0019863
name: IgE binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an immunoglobulin of the IgE isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0019864
name: IgG binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an immunoglobulin of an IgG isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0019865
name: immunoglobulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an immunoglobulin." [GOC:ma]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0019866
name: organelle inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah]
comment: See also the cellular component term 'outer membrane ; GO:0019867'.
subset: gosubset_prok
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0031967 ! organelle envelope

[Term]
id: GO:0019867
name: outer membrane
namespace: cellular_component
def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0016020 ! membrane

[Term]
id: GO:0019869
name: chloride channel inhibitor activity
namespace: molecular_function
def: "Stops, prevents, or reduces the activity of a chloride channel." [GOC:mah]
is_a: GO:0008200 ! ion channel inhibitor activity
is_a: GO:0017081 ! chloride channel regulator activity

[Term]
id: GO:0019870
name: potassium channel inhibitor activity
namespace: molecular_function
def: "Stops, prevents, or reduces the activity of a potassium channel." [GOC:mah]
is_a: GO:0008200 ! ion channel inhibitor activity
is_a: GO:0015459 ! potassium channel regulator activity

[Term]
id: GO:0019871
name: sodium channel inhibitor activity
namespace: molecular_function
alt_id: GO:0019868
def: "Stops, prevents, or reduces the activity of a sodium channel." [GOC:mah]
is_a: GO:0008200 ! ion channel inhibitor activity
is_a: GO:0017080 ! sodium channel regulator activity

[Term]
id: GO:0019872
name: streptomycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "streptomycin anabolism" EXACT []
synonym: "streptomycin biosynthesis" EXACT []
synonym: "streptomycin formation" EXACT []
synonym: "streptomycin synthesis" EXACT []
is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process
is_a: GO:0046343 ! streptomycin metabolic process

[Term]
id: GO:0019873
name: tellurium sensitivity/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046690

[Term]
id: GO:0019874
name: 6-aminohexanoate-cyclic-dimer hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate." [EC:3.5.2.12]
subset: gosubset_prok
synonym: "1,8-diazacyclotetradecane-2,9-dione lactamhydrolase activity" EXACT [EC:3.5.2.12]
xref: EC:3.5.2.12
xref: MetaCyc:3.5.2.12-RXN
xref: UM-BBD_enzymeID:e0674
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0019875
name: 6-aminohexanoate-dimer hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate." [EC:3.5.1.46]
subset: gosubset_prok
synonym: "6-aminohexanoic acid oligomer hydrolase activity" EXACT [EC:3.5.1.46]
synonym: "N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase activity" EXACT [EC:3.5.1.46]
xref: EC:3.5.1.46
xref: MetaCyc:RXN-3962
xref: UM-BBD_enzymeID:e0673
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0019876
name: nylon catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids." [SP_KW:KW-0549]
subset: gosubset_prok
synonym: "nylon breakdown" EXACT []
synonym: "nylon catabolism" EXACT []
synonym: "nylon degradation" EXACT []
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042198 ! nylon metabolic process

[Term]
id: GO:0019877
name: diaminopimelate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls." [GOC:ma, ISBN:0198547684]
subset: gosubset_prok
synonym: "diaminopimelate anabolism" EXACT []
synonym: "diaminopimelate biosynthesis" EXACT []
synonym: "diaminopimelate formation" EXACT []
synonym: "diaminopimelate synthesis" EXACT []
is_a: GO:0046394 ! carboxylic acid biosynthetic process
is_a: GO:0046451 ! diaminopimelate metabolic process
relationship: part_of GO:0009089 ! lysine biosynthetic process via diaminopimelate

[Term]
id: GO:0019878
name: lysine biosynthetic process via aminoadipic acid
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway." [GOC:go_curators]
subset: gosubset_prok
synonym: "lysine anabolism via aminoadipic acid" EXACT []
synonym: "lysine biosynthesis, aminoadipic acid pathway" EXACT []
synonym: "lysine biosynthesis, aminoadipic pathway" EXACT []
synonym: "lysine biosynthetic process, aminoadipic acid pathway" EXACT []
synonym: "lysine biosynthetic process, aminoadipic pathway" EXACT []
synonym: "lysine formation via aminoadipic acid" EXACT []
synonym: "lysine synthesis via aminoadipic acid" EXACT []
is_a: GO:0009085 ! lysine biosynthetic process

[Term]
id: GO:0019879
name: peptidyl-thyronine biosynthetic process from peptidyl-tyrosine
namespace: biological_process
def: "The formation of peptidyl-thyronine from peptidyl-tyrosine in thyroglobulin by phenyl transfer coupled with the formation of peptidyl-dehydroalanine." [GOC:jsg]
comment: See also the biological process term 'peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine ; GO:0018250'.
subset: gosubset_prok
synonym: "peptidyl-thyronine anabolism from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-thyronine formation from peptidyl-tyrosine" EXACT []
synonym: "peptidyl-thyronine synthesis from peptidyl-tyrosine" EXACT []
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0019880
name: bacteriocin susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046678

[Term]
id: GO:0019881
name: streptomycin susceptibility/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046679

[Term]
id: GO:0019882
name: antigen processing and presentation
namespace: biological_process
alt_id: GO:0030333
def: "The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology", PMID:15771591, PMID:15928678]
comment: This term was improved by GO_REF:0000022. It was renamed and redefined.
synonym: "antigen presentation" EXACT []
synonym: "antigen processing" EXACT []
xref: Wikipedia:Antigen_presentation
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0019883
name: antigen processing and presentation of endogenous antigen
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591, PMID:15928678]
synonym: "antigen presentation, endogenous antigen" EXACT []
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0019884
name: antigen processing and presentation of exogenous antigen
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591, PMID:15928678]
synonym: "antigen presentation, exogenous antigen" EXACT []
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0019885
name: antigen processing and presentation of endogenous peptide antigen via MHC class I
namespace: biological_process
alt_id: GO:0048004
def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
synonym: "antigen presentation, endogenous peptide antigen" BROAD []
synonym: "antigen processing, endogenous antigen via major histocompatibility complex class I" BROAD []
synonym: "antigen processing, endogenous antigen via MHC class I" BROAD []
synonym: "endogenous peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen

[Term]
id: GO:0019886
name: antigen processing and presentation of exogenous peptide antigen via MHC class II
namespace: biological_process
alt_id: GO:0042591
alt_id: GO:0048005
def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
synonym: "antigen presentation, exogenous antigen via MHC class II" BROAD []
synonym: "antigen presentation, exogenous peptide antigen" BROAD []
synonym: "antigen processing, exogenous antigen via major histocompatibility complex class II" BROAD []
synonym: "exogenous peptide antigen processing and presentation via MHC class II" EXACT []
is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen
is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II

[Term]
id: GO:0019887
name: protein kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0019207 ! kinase regulator activity

[Term]
id: GO:0019888
name: protein phosphatase regulator activity
namespace: molecular_function
def: "Modulation of the activity of a protein phosphatase enzyme." [GOC:ai]
is_a: GO:0019208 ! phosphatase regulator activity

[Term]
id: GO:0019889
name: pteridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pteridine metabolism" EXACT []
is_a: GO:0042558 ! pteridine and derivative metabolic process

[Term]
id: GO:0019893
name: DNA replication inhibitor
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it does not represent a true molecular function.
is_obsolete: true
replaced_by: GO:0008156

[Term]
id: GO:0019894
name: kinesin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and stoichiometrically with kinesin, a cytoplasmic protein responsible for moving vesicles and organelles towards the distal end of microtubules." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0019895
name: kinesin-associated mitochondrial adaptor activity
namespace: molecular_function
def: "The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to mitochondria." [http://cancerweb.ncl.ac.uk/, PMID:12495622]
is_a: GO:0019894 ! kinesin binding
is_a: GO:0060090 ! molecular adaptor activity

[Term]
id: GO:0019896
name: axon transport of mitochondrion
namespace: biological_process
def: "The directed movement of mitochondria along microtubules in nerve cell axons." [GOC:ai]
synonym: "axon transport of mitochondria" EXACT []
is_a: GO:0008088 ! axon cargo transport

[Term]
id: GO:0019897
name: extrinsic to plasma membrane
namespace: cellular_component
alt_id: GO:0000157
def: "Loosely bound to one surface of the plasma membrane, but not integrated into the hydrophobic region." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "juxtamembrane" BROAD []
synonym: "peripheral plasma membrane protein" EXACT []
is_a: GO:0019898 ! extrinsic to membrane
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0019898
name: extrinsic to membrane
namespace: cellular_component
alt_id: GO:0030396
def: "Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region." [GOC:jl, GOC:mah, http://cancerweb.ncl.ac.uk/]
comment: Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions.
subset: gosubset_prok
synonym: "peripheral membrane protein" EXACT []
xref: Wikipedia:Peripheral_membrane_protein
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0019899
name: enzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any enzyme." [GOC:jl]
subset: gosubset_prok
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0019900
name: kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0019901
name: protein kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl]
is_a: GO:0019900 ! kinase binding

[Term]
id: GO:0019902
name: phosphatase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any phosphatase." [GOC:jl]
subset: gosubset_prok
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0019903
name: protein phosphatase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein phosphatase." [GOC:jl]
subset: gosubset_prok
is_a: GO:0019902 ! phosphatase binding

[Term]
id: GO:0019904
name: protein domain specific binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators]
subset: gosubset_prok
synonym: "protein domain-specific binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0019905
name: syntaxin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0000149 ! SNARE binding

[Term]
id: GO:0019907
name: cyclin-dependent protein kinase activating kinase holoenzyme complex
namespace: cellular_component
def: "A protein complex that phosphorylates cyclin-dependent kinases such as Cdc2 on Thr161 (or an equivalent residue); contains a catalytic subunit and a regulatory subunit, and some examples also include an assembly factor." [GOC:mah, PMID:8752210]
synonym: "CAK complex" EXACT []
synonym: "CDK-activating kinase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0019908
name: nuclear cyclin-dependent protein kinase holoenzyme complex
namespace: cellular_component
def: "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc]
synonym: "CDK holoenzyme" BROAD []
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0019909
name: [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity
namespace: molecular_function
def: "Modification of the activity of the enzyme [pyruvate dehydrogenase (lipoamide)] phosphatase." [EC:3.1.3.43, GOC:ai]
synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic regulator activity" NARROW []
is_a: GO:0019888 ! protein phosphatase regulator activity

[Term]
id: GO:0019910
name: mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex
namespace: cellular_component
def: "A mitochondrial complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. An example of this component is found in Mus musculus." [GOC:mtg_sensu, PMID:9395502]
comment: See also the cellular component term 'mitochondrial pyruvate dehydrogenase complex ; GO:0005967'.
is_a: GO:0044429 ! mitochondrial part
is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0019911
name: structural constituent of myelin sheath
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0019912
name: cyclin-dependent protein kinase activating kinase activity
namespace: molecular_function
alt_id: GO:0019913
def: "Increases the activity of a cyclin-dependent protein kinase (CDK)." [GOC:go_curators]
synonym: "CAK" EXACT []
synonym: "cyclin-dependent protein kinase activating kinase, intrinsic catalyst activity" EXACT []
xref: EC:2.7.11.-
xref: MetaCyc:2.7.11.22-RXN
is_a: GO:0004672 ! protein kinase activity
is_a: GO:0030295 ! protein kinase activator activity

[Term]
id: GO:0019914
name: cyclin-dependent protein kinase activating kinase regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase." [GOC:ai]
synonym: "cyclin-dependent protein kinase activating kinase, intrinsic regulator activity" NARROW []
xref: EC:2.7.1.-
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0019915
name: lipid storage
namespace: biological_process
def: "The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830]
synonym: "lipid retention" EXACT [GOC:dph, GOC:tb]
synonym: "lipid sequestering" NARROW [GOC:dph, GOC:tb]
synonym: "lipid sequestration" NARROW [GOC:dph, GOC:tb]
synonym: "retention of lipids" EXACT [GOC:dph, GOC:tb]
synonym: "sequestering of lipids" NARROW [GOC:dph, GOC:tb]
synonym: "sequestration of lipid" NARROW [GOC:dph, GOC:tb]
synonym: "sequestration of lipids" EXACT [GOC:dph, GOC:tb]
synonym: "storage of lipids" EXACT []
is_a: GO:0010876 ! lipid localization

[Term]
id: GO:0019916
name: peptidyl-D-alanine racemization, direct
namespace: biological_process
def: "The racemization of peptidyl-alanine." [RESID:AA0191]
subset: gosubset_prok
xref: RESID:AA0191
is_a: GO:0019122 ! peptidyl-D-alanine racemization

[Term]
id: GO:0019917
name: peptidyl-D-alanine racemization via peptidyl-L-serine
namespace: biological_process
def: "The dehydration of peptidyl-serine, followed by hydrogenation to produce peptidyl-D-alanine." [RESID:AA0191]
subset: gosubset_prok
xref: RESID:AA0191
is_a: GO:0019122 ! peptidyl-D-alanine racemization

[Term]
id: GO:0019918
name: peptidyl-arginine methylation, to symmetrical-dimethyl arginine
namespace: biological_process
def: "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine." [RESID:AA0067, RESID:AA0069]
subset: gosubset_prok
xref: RESID:AA0067
xref: RESID:AA0069
is_a: GO:0035247 ! peptidyl-arginine omega-N-methylation

[Term]
id: GO:0019919
name: peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
namespace: biological_process
def: "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine." [RESID:AA0068, RESID:AA0069]
subset: gosubset_prok
synonym: "peptidyl-arginine methylation, to unsymmetrical-dimethyl arginine" EXACT []
xref: RESID:AA0068
xref: RESID:AA0069
is_a: GO:0035247 ! peptidyl-arginine omega-N-methylation

[Term]
id: GO:0019920
name: peptidyl-1-thioglycine biosynthetic process, internal
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of internal peptidyl-1-thioglycine, which has an internal C=S bond, instead of an internal C=O bond, in the peptide." [GOC:go_curators, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265]
subset: gosubset_prok
synonym: "peptidyl-1-thioglycine anabolism, internal" EXACT []
synonym: "peptidyl-1-thioglycine formation, internal" EXACT []
synonym: "peptidyl-1-thioglycine synthesis, internal" EXACT []
xref: RESID:AA0265
is_a: GO:0018173 ! peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine

[Term]
id: GO:0019921
name: peptidyl-1-thioglycine biosynthetic process, carboxy-terminal
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carboxy-terminal peptidyl-1-thioglycine, which has a carboxy-terminal thiocarboxy-C(=O)-SH bond." [GOC:go_curators, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265]
subset: gosubset_prok
synonym: "peptidyl-1-thioglycine anabolism, carboxy-terminal" EXACT []
synonym: "peptidyl-1-thioglycine formation, carboxy-terminal" EXACT []
synonym: "peptidyl-1-thioglycine synthesis, carboxy-terminal" EXACT []
xref: RESID:AA0265
is_a: GO:0018173 ! peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine

[Term]
id: GO:0019922
name: protein-chromophore linkage via peptidyl-cysteine
namespace: biological_process
def: "The covalent linking of a chromophore to a protein via peptidyl-cysteines." [GOC:ma]
subset: gosubset_prok
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0019923
name: alpha-1-microglobulin-chromophore linkage
namespace: biological_process
def: "The covalent linking of the alpha-1-microglobulin chromophore to the protein; the structure of the chromophore is not known. It is probably heterogeneous and involving two cysteines in thioether bonds." [RESID:AA0224]
subset: gosubset_prok
xref: RESID:AA0224
is_a: GO:0019922 ! protein-chromophore linkage via peptidyl-cysteine

[Term]
id: GO:0019926
name: peptidyl-tryptophan oxidation to tryptophyl quinone
namespace: biological_process
def: "The posttranslational oxidation of peptidyl-tryptophan to form tryptophan-6,7-dione, otherwise known as tryptophyl quinone, which is further modified by cross-linking to either tryptophan or cysteine." [PMID:2028257, RESID:AA0148]
comment: See also the biological process term 'peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone ; GO:0018069'.
subset: gosubset_prok
is_a: GO:0018158 ! protein amino acid oxidation
is_a: GO:0018211 ! peptidyl-tryptophan modification
relationship: part_of GO:0018069 ! peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone

[Term]
id: GO:0019927
name: peptide cross-linking via 4'-(S-L-cysteinyl)-L-tryptophyl quinone
namespace: biological_process
def: "The posttranslational cross-linking of a cysteine residue to tryptophyl quinone to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone, a cofactor found at the active site of amine dehydrogenase." [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0313]
subset: gosubset_prok
xref: RESID:AA0313
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0019928
name: peptide cross-linking via 3-(S-L-cysteinyl)-L-aspartic acid
namespace: biological_process
def: "The posttranslational cross-linking of a cysteine residue to an aspartic acid residue to form 3-(S-L-cysteinyl)-L-aspartic acid." [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0314]
subset: gosubset_prok
xref: RESID:AA0314
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018197 ! peptidyl-aspartic acid modification
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0019929
name: peptide cross-linking via 4-(S-L-cysteinyl)-L-glutamic acid
namespace: biological_process
def: "The posttranslational cross-linking of a cysteine residue to a glutamic acid residue to form 4-(S-L-cysteinyl)-L-glutamic acid." [RESID:AA0315]
subset: gosubset_prok
xref: RESID:AA0315
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018200 ! peptidyl-glutamic acid modification

[Term]
id: GO:0019930
name: cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester biosynthetic process from peptidyl-aspartic acid
namespace: biological_process
def: "The posttranslational modification of peptidyl-aspartic acid to form peptidyl-cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester, typical of the barley lipid transfer protein 1." [RESID:AA0316]
subset: gosubset_prok
synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester anabolism from peptidyl-aspartic acid" EXACT []
synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester formation from peptidyl-aspartic acid" EXACT []
synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester synthesis from peptidyl-aspartic acid" EXACT []
xref: RESID:AA0316
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0019931
name: protein-chromophore linkage via peptidyl-N6-3-dehydroretinal-L-lysine
namespace: biological_process
def: "The posttranslation modification of peptidyl-lysine to form N6-3,4-didehydroretinylidene-L-lysine." [RESID:AA0312]
subset: gosubset_prok
xref: RESID:AA0312
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0019932
name: second-messenger-mediated signaling
namespace: biological_process
def: "A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell." [GOC:mah, ISBN:0815316194]
subset: gosubset_prok
synonym: "second messenger mediated signaling" EXACT []
synonym: "second messenger mediated signalling" EXACT []
synonym: "second messenger-mediated signaling" EXACT []
synonym: "second messenger-mediated signalling" EXACT []
synonym: "second-messenger-mediated signalling" EXACT []
is_a: GO:0007242 ! intracellular signaling cascade

[Term]
id: GO:0019933
name: cAMP-mediated signaling
namespace: biological_process
def: "A series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:mah]
synonym: "3',5' cAMP-mediated signaling" EXACT []
synonym: "3',5' cAMP-mediated signalling" EXACT []
synonym: "3',5'-cAMP-mediated signaling" EXACT []
synonym: "3',5'-cAMP-mediated signalling" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-mediated signaling" EXACT []
synonym: "adenosine 3',5'-cyclophosphate-mediated signalling" EXACT []
synonym: "cAMP signaling" EXACT []
synonym: "cAMP signalling" EXACT []
synonym: "cAMP-mediated signal transduction" EXACT []
synonym: "cAMP-mediated signalling" EXACT []
synonym: "cyclic AMP-mediated signaling" EXACT []
synonym: "cyclic AMP-mediated signalling" EXACT []
is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling

[Term]
id: GO:0019934
name: cGMP-mediated signaling
namespace: biological_process
def: "A series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:mah]
synonym: "cGMP-mediated signalling" EXACT []
is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling

[Term]
id: GO:0019935
name: cyclic-nucleotide-mediated signaling
namespace: biological_process
def: "A series of molecular signals in which a cell uses a cyclic nucleotide to convert an extracellular signal into a response." [GOC:ceb]
subset: gosubset_prok
synonym: "cyclic-nucleotide-mediated signalling" EXACT []
is_a: GO:0019932 ! second-messenger-mediated signaling

[Term]
id: GO:0019936
name: inositol phospholipid-mediated signaling
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ceb]
comment: This term was made obsolete because it did not adequately describe phosphoinositide-mediated signaling.
synonym: "inositol phospholipid-mediated signalling" EXACT []
is_obsolete: true
consider: GO:0048015
consider: GO:0048016
consider: GO:0048017

[Term]
id: GO:0019937
name: protein catenane formation via N6-(L-isoaspartyl)-L-lysine, autocatalytic
namespace: biological_process
def: "The autocatalytic formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; known to occur in the capsid of some bacteriophage, such as HK97, where it is thought to provide a mechanism for stabilizing the capsid." [RESID:AA0294]
subset: gosubset_prok
xref: RESID:AA0294
is_a: GO:0018419 ! protein catenane formation
is_a: GO:0018420 ! peptide cross-linking via N6-(L-isoaspartyl)-L-lysine

[Term]
id: GO:0019938
name: peptide cross-linking via N6-(L-isoaspartyl)-L-lysine, presumed catalytic
namespace: biological_process
alt_id: GO:0042266
def: "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; occurs in mammals in proteins as yet unidentified by a mechanism probably analogous to that of transglutaminase reactions." [RESID:AA0294]
subset: gosubset_prok
xref: RESID:AA0294
is_a: GO:0018420 ! peptide cross-linking via N6-(L-isoaspartyl)-L-lysine

[Term]
id: GO:0019939
name: peptidyl-S-palmitoleyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def: "The posttranslational modification of peptidyl-cysteine to form peptidyl-S-palmitoleyl-L-cysteine specifically." [RESID:AA0308]
subset: gosubset_prok
synonym: "peptidyl-S-palmitoleyl-L-cysteine anabolism from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-palmitoleyl-L-cysteine formation from peptidyl-cysteine" EXACT []
synonym: "peptidyl-S-palmitoleyl-L-cysteine synthesis from peptidyl-cysteine" EXACT []
xref: RESID:AA0308
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0045235 ! protein amino acid palmitoleylation

[Term]
id: GO:0019940
name: SUMO-dependent protein catabolic process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it does not reflect an accurate biological process, as sumoylation of a protein does not lead to catabolism of that protein.
synonym: "SUMO-dependent protein breakdown" EXACT []
synonym: "SUMO-dependent protein catabolism" EXACT []
synonym: "SUMO-dependent protein degradation" EXACT []
is_obsolete: true
consider: GO:0016925
consider: GO:0016926

[Term]
id: GO:0019941
name: modification-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators]
subset: gosubset_prok
synonym: "modification-dependent protein breakdown" EXACT []
synonym: "modification-dependent protein catabolism" EXACT []
synonym: "modification-dependent protein degradation" EXACT []
synonym: "modification-dependent proteolysis" EXACT [GOC:rl]
synonym: "modification-initiated protein catabolic process" EXACT [GOC:rl]
synonym: "modification-initiated protein catabolism" EXACT [GOC:rl]
synonym: "modification-initiated proteolysis" EXACT [GOC:rl]
synonym: "protein degradation tagging activity" RELATED []
synonym: "protein-ligand-dependent protein catabolic process" NARROW []
synonym: "protein-ligand-dependent protein catabolism" NARROW []
is_a: GO:0043632 ! modification-dependent macromolecule catabolic process
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process

[Term]
id: GO:0019942
name: NEDD8 class-dependent protein catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to the target protein." [GOC:jl]
comment: This term was made obsolete because NEDD8-class tags do not target proteins for proteolytic destruction.
synonym: "NEDD8 class-dependent protein breakdown" EXACT []
synonym: "NEDD8 class-dependent protein catabolism" EXACT []
synonym: "NEDD8 class-dependent protein degradation" EXACT []
synonym: "RUB1-dependent protein catabolic process" EXACT []
synonym: "RUB1-dependent protein catabolism" EXACT []
synonym: "RUB1-dependent protein degradation" EXACT []
is_obsolete: true
consider: GO:0045116

[Term]
id: GO:0019948
name: SUMO activating enzyme activity
namespace: molecular_function
alt_id: GO:0017115
def: "Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:rn, PMID:10187858, PMID:11265250]
synonym: "SMT3 activating enzyme" EXACT []
synonym: "SUMO E1 activator enzyme" EXACT []
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0019950
name: SMT3-dependent protein catabolic process
namespace: biological_process
alt_id: GO:0019946
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein SMT3 to the target protein." [GOC:jl, PMID:9435231]
synonym: "SMT3-dependent protein breakdown" EXACT []
synonym: "SMT3-dependent protein catabolism" EXACT []
synonym: "SMT3-dependent protein degradation" EXACT []
is_a: GO:0019941 ! modification-dependent protein catabolic process

[Term]
id: GO:0019951
name: Smt3-protein conjugation
namespace: biological_process
alt_id: GO:0019947
def: "The covalent addition to a protein of Smt3, a ubiquitin-like protein." [GOC:jl]
synonym: "Smt3p-protein conjugation" EXACT []
is_a: GO:0032446 ! protein modification by small protein conjugation
is_a: GO:0043687 ! post-translational protein modification
relationship: part_of GO:0019950 ! SMT3-dependent protein catabolic process

[Term]
id: GO:0019953
name: sexual reproduction
namespace: biological_process
def: "The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times." [ISBN:0387520546]
xref: Wikipedia:Sexual_reproduction
is_a: GO:0000003 ! reproduction

[Term]
id: GO:0019954
name: asexual reproduction
namespace: biological_process
def: "The biological process by which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process." [ISBN:0387520546]
subset: gosubset_prok
xref: Wikipedia:Asexual_reproduction
is_a: GO:0000003 ! reproduction

[Term]
id: GO:0019955
name: cytokine binding
namespace: molecular_function
alt_id: GO:0019965
def: "Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471]
synonym: "IL binding" NARROW []
synonym: "interleukin binding" NARROW []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0019956
name: chemokine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a chemokine, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions." [GOC:ai]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019957
name: C-C chemokine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai]
is_a: GO:0019956 ! chemokine binding

[Term]
id: GO:0019958
name: C-X-C chemokine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif." [GOC:ai]
is_a: GO:0019956 ! chemokine binding

[Term]
id: GO:0019959
name: interleukin-8 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-8." [GOC:jl]
synonym: "IL-8 binding" EXACT []
is_a: GO:0019958 ! C-X-C chemokine binding

[Term]
id: GO:0019960
name: C-X3-C chemokine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai]
is_a: GO:0019956 ! chemokine binding

[Term]
id: GO:0019961
name: interferon binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent." [Wikipedia:Interferon]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019962
name: type I interferon binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]
synonym: "interferon-alpha binding" NARROW []
synonym: "interferon-alpha/beta binding" NARROW []
synonym: "interferon-beta binding" NARROW []
synonym: "interferon-delta binding" NARROW []
synonym: "interferon-epsilon binding" NARROW []
synonym: "interferon-kappa binding" NARROW []
synonym: "interferon-omega binding" NARROW []
synonym: "interferon-tau binding" NARROW []
synonym: "interferon-zeta binding" NARROW []
is_a: GO:0019961 ! interferon binding

[Term]
id: GO:0019964
name: interferon-gamma binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interferon-gamma. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383]
synonym: "type II interferon binding" EXACT []
is_a: GO:0019961 ! interferon binding

[Term]
id: GO:0019966
name: interleukin-1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-1." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "IL-1 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019969
name: interleukin-10 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-10." [GOC:jl]
synonym: "IL-10 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019970
name: interleukin-11 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-11." [GOC:jl]
synonym: "IL-11 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019972
name: interleukin-12 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-12." [GOC:jl]
synonym: "IL-12 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019973
name: interleukin-13 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-13." [GOC:jl]
synonym: "IL-13 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019974
name: interleukin-14 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-14." [GOC:jl]
synonym: "IL-14 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019975
name: interleukin-17 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-17." [GOC:jl]
synonym: "IL-17 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019976
name: interleukin-2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-2." [GOC:jl]
synonym: "IL-2 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019977
name: interleukin-21 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-21." [GOC:jl]
synonym: "IL-21 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019978
name: interleukin-3 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-3." [GOC:jl]
synonym: "IL-3 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019979
name: interleukin-4 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-4." [GOC:jl]
synonym: "IL-4 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019980
name: interleukin-5 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-5." [GOC:jl]
synonym: "IL-5 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019981
name: interleukin-6 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-6." [GOC:jl]
synonym: "IL-6 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019982
name: interleukin-7 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-7." [GOC:jl]
synonym: "IL-7 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019983
name: interleukin-9 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-9." [GOC:jl]
synonym: "IL-9 binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0019985
name: translesion synthesis
namespace: biological_process
def: "The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, PMID:10535901]
subset: gosubset_prok
synonym: "bypass DNA synthesis" EXACT [GOC:elh]
is_a: GO:0006261 ! DNA-dependent DNA replication
is_a: GO:0006301 ! postreplication repair

[Term]
id: GO:0019987
name: negative regulation of anti-apoptosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anti-apoptosis." [GOC:go_curators]
synonym: "down regulation of anti-apoptosis" EXACT []
synonym: "down-regulation of anti-apoptosis" EXACT []
synonym: "downregulation of anti-apoptosis" EXACT []
synonym: "inhibition of anti-apoptosis" NARROW []
is_a: GO:0045767 ! regulation of anti-apoptosis
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0006916 ! anti-apoptosis

[Term]
id: GO:0019988
name: charged-tRNA amino acid modification
namespace: biological_process
alt_id: GO:0030630
def: "The covalent alteration of an amino acid charged on a tRNA before it is incorporated into a protein, as in N-formylmethionine, selenocysteine or pyrrolysine." [GOC:jsg]
subset: gosubset_prok
synonym: "charged tRNA amino acid modification" EXACT []
synonym: "charged tRNA modification" EXACT []
synonym: "charged-tRNA modification" RELATED []
synonym: "pre-translational amino acid modification" EXACT []
synonym: "pre-translational protein modification" EXACT []
synonym: "pretranslation protein modification" EXACT []
synonym: "pretranslational amino acid modification" EXACT []
is_a: GO:0006400 ! tRNA modification
is_a: GO:0006464 ! protein modification process

[Term]
id: GO:0019990
name: pteridine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pteridine breakdown" EXACT []
synonym: "pteridine catabolism" EXACT []
synonym: "pteridine degradation" EXACT []
is_a: GO:0019889 ! pteridine metabolic process
is_a: GO:0042560 ! pteridine and derivative catabolic process

[Term]
id: GO:0019991
name: septate junction assembly
namespace: biological_process
def: "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, http://cancerweb.ncl.ac.uk/]
is_a: GO:0007043 ! cell-cell junction assembly
relationship: part_of GO:0043297 ! apical junction assembly

[Term]
id: GO:0019992
name: diacylglycerol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids." [GOC:ma]
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0020002
name: host cell plasma membrane
namespace: cellular_component
def: "The plasma membrane surrounding a host cell." [GOC:mb]
subset: gosubset_prok
is_a: GO:0033644 ! host cell membrane

[Term]
id: GO:0020003
name: parasitophorous vacuole
namespace: cellular_component
def: "Vacuole within a host cell in which a parasite resides." [GOC:mb]
comment: Note that this term does not have a relationship to 'vacuole ; GO:0005773' because it does not fit the definition of a vacuole; the parasitophorous vacuole was so named because it resembles a vacuole in the microscope.
is_a: GO:0033655 ! host cell cytoplasm part
is_a: GO:0043230 ! extracellular organelle

[Term]
id: GO:0020004
name: parasitophorous vacuolar space
namespace: cellular_component
def: "Space between a parasite plasma membrane and the parasitophorous vacuolar membrane." [GOC:mb]
is_a: GO:0033643 ! host cell part
is_a: GO:0044422 ! organelle part
relationship: part_of GO:0020003 ! parasitophorous vacuole

[Term]
id: GO:0020005
name: parasitophorous vacuolar membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a parasitophorous vacuole." [GOC:mb]
is_a: GO:0005774 ! vacuolar membrane
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0020003 ! parasitophorous vacuole

[Term]
id: GO:0020006
name: parasitophorous vacuolar membrane network
namespace: cellular_component
def: "Tubular network of extensions from the parasitophorous vacuolar membrane that protrude into the host cytoplasm." [PMID:3528173]
synonym: "tubulovesicular network" NARROW []
is_a: GO:0033643 ! host cell part
is_a: GO:0044425 ! membrane part
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0020005 ! parasitophorous vacuolar membrane

[Term]
id: GO:0020007
name: apical complex
namespace: cellular_component
def: "Protruding complex at the anterior end of some life cycle stages of all apicomplexan parasites, involved in both the attachment and penetration of the host cell by the parasite." [GOC:mb]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0045177 ! apical part of cell

[Term]
id: GO:0020008
name: rhoptry
namespace: cellular_component
def: "A large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite, and consists of a bulbous body and a narrow electron-dense neck that extends through the conoid at the apical tip of the parasite. The rhoptry necks serve as ducts through which the contents of the rhoptries are secreted after attachment to the host has been completed and at the commencement of invasion. Rhoptry proteins function in the biogenesis and host organellar association of the parasitophorous vacuole." [ISBN:0521664470, PMID:11801218, PMID:16002398]
synonym: "paired organelles" RELATED []
synonym: "toxoneme" RELATED []
xref: Wikipedia:Rhoptry
is_a: GO:0044464 ! cell part
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020009
name: microneme
namespace: cellular_component
def: "A small, elongated secretory organelle that forms part of the apical complex, located along the main axis of an apicomplexan parasite cell within the extreme apical region and at the periphery under the inner membrane complex. Of the specialized secretory compartments identified in apicomplexans, micronemes discharge their contents first, during initial contact of the parasite's apical pole with the host cell surface. Micronemal proteins function during parasite attachment and penetration into the target cell." [ISBN:0521664470, PMID:11801218]
synonym: "sarconeme" RELATED []
xref: Wikipedia:Microneme
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020010
name: conoid
namespace: cellular_component
def: "A spiral cytoskeletal structure located at the apical end of the apical complex in some apicomplexan parasites. Fibers form a left-handed spiral, and are comprised of tubulin protofilaments organized in a ribbon-like structure that differs from the conventional tubular structure characteristic of microtubules." [GOC:expert_dr, PMID:11901169, PMID:16518471]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020011
name: apicoplast
namespace: cellular_component
def: "The plastid organelle found in apicomplexans." [ISBN:0521664470]
xref: Wikipedia:Apicoplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0020012
name: evasion or tolerance of host immune response
namespace: biological_process
def: "Any process, either active or passive, by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb]
subset: gosubset_prok
synonym: "immune evasion" BROAD []
is_a: GO:0030682 ! evasion or tolerance of host defense response
is_a: GO:0051805 ! evasion or tolerance of immune response of other organism during symbiotic interaction
is_a: GO:0052572 ! response to host immune response

[Term]
id: GO:0020013
name: rosetting
namespace: biological_process
def: "The binding of parasite infected erythrocytes to uninfected erythrocytes." [GOC:mb]
xref: Wikipedia:Rosetting
is_a: GO:0007157 ! heterophilic cell adhesion

[Term]
id: GO:0020014
name: schizogony
namespace: biological_process
def: "Cell division by multiple fission in which nuclei and other organelles in the parent cell divide repeatedly and move to the cell periphery before internal membranes develop around them, producing a large number of daughter cells simultaneously." [GOC:mb]
xref: Wikipedia:Protozoal_merogony
is_a: GO:0051301 ! cell division

[Term]
id: GO:0020015
name: glycosome
namespace: cellular_component
def: "A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis." [GOC:mb]
subset: goslim_pir
xref: Wikipedia:Glycosome
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0020016
name: flagellar pocket
namespace: cellular_component
def: "Invagination of the plasma membrane from which a flagellum protrudes." [GOC:mb]
is_a: GO:0044442 ! microtubule-based flagellum part

[Term]
id: GO:0020017
name: flagellar membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the flagellum." [GOC:mah, GOC:mb]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0044442 ! microtubule-based flagellum part

[Term]
id: GO:0020018
name: flagellar pocket membrane
namespace: cellular_component
def: "That part of the plasma membrane found in the flagellar pocket." [GOC:mb]
is_a: GO:0020017 ! flagellar membrane
relationship: part_of GO:0020016 ! flagellar pocket

[Term]
id: GO:0020020
name: food vacuole
namespace: cellular_component
alt_id: GO:0005772
def: "Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa." [GOC:mb]
synonym: "digestive vacuole" EXACT []
is_a: GO:0032010 ! phagolysosome

[Term]
id: GO:0020021
name: immortalization of host cell
namespace: biological_process
def: "The modification of a host cell into an immortal cell line as a consequence of infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb]
synonym: "host cell immortalization" EXACT []
synonym: "host cell transformation" EXACT []
synonym: "transformation of host cell" EXACT []
is_a: GO:0051701 ! interaction with host

[Term]
id: GO:0020022
name: acidocalcisome
namespace: cellular_component
def: "An electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations." [GOC:mb]
subset: goslim_pir
synonym: "metachromatic granule" EXACT [PMID:15738951]
synonym: "polyphosphate vacuole" RELATED [PMID:15738951]
synonym: "volutin granule" EXACT [PMID:15738951]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0020023
name: kinetoplast
namespace: cellular_component
def: "A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum." [GOC:mb]
xref: Wikipedia:Kinetoplast
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0020025
name: subpellicular microtubule
namespace: cellular_component
def: "Singlet microtubules that lie underneath the inner membrane complex and emanate from the basal ring of the conoid." [GOC:mb]
is_a: GO:0005874 ! microtubule
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020026
name: merozoite dense granule
namespace: cellular_component
def: "Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell." [GOC:mb, GOC:mtg_sensu]
synonym: "dense body" EXACT []
is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0020027
name: hemoglobin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hemoglobin, including its uptake and utilization." [GOC:go_curators, GOC:jl]
synonym: "haemoglobin metabolic process" EXACT []
synonym: "haemoglobin metabolism" EXACT []
synonym: "hemoglobin metabolism" EXACT []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0020028
name: hemoglobin import
namespace: biological_process
def: "The directed movement into a tissue, cell or organelle of externally available hemoglobin." [GOC:mb]
synonym: "haemoglobin uptake" EXACT []
synonym: "hemoglobin uptake" EXACT []
is_a: GO:0017038 ! protein import

[Term]
id: GO:0020030
name: infected host cell surface knob
namespace: cellular_component
def: "Protrusion that develops in the plasma membrane of a parasitized erythrocyte. An example of this component is found in Plasmodium species." [GOC:mb]
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0020031
name: polar ring of apical complex
namespace: cellular_component
def: "An electron dense ring at the most anterior position of the apical complex, from which the conoid fibers originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mb, PMID:16518471]
synonym: "anterior polar ring of apical complex" EXACT []
synonym: "upper polar ring of apical complex" EXACT []
is_a: GO:0044464 ! cell part
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020032
name: basal ring of apical complex
namespace: cellular_component
def: "An electron dense ring at the most posterior position of the apical complex, from which the subpellicular microtubules originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mah, PMID:16518471]
synonym: "lower polar ring of apical complex" EXACT []
synonym: "posterior polar ring of apical complex" EXACT []
synonym: "preconoidal ring of apical complex" EXACT []
is_a: GO:0044464 ! cell part
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0020033
name: antigenic variation
namespace: biological_process
alt_id: GO:0020034
def: "Any process involved in the biological strategy of changing antigenic determinants on the surface that are exposed to another organism's immune system." [GOC:mb]
subset: gosubset_prok
synonym: "surface antigen variation" NARROW []
xref: Wikipedia:Antigenic_variation
is_a: GO:0051809 ! passive evasion of immune response of other organism during symbiotic interaction

[Term]
id: GO:0020035
name: cytoadherence to microvasculature, mediated by parasite protein
namespace: biological_process
def: "The adherence of parasite-infected erythrocytes to microvascular endothelium via parasite proteins embedded in the membrane of the erythrocyte." [GOC:mb]
synonym: "cytoadherence to microvasculature, mediated by symbiont protein" BROAD []
synonym: "parasite-protein-mediated cytoadherence to microvasculature" EXACT []
synonym: "symbiont-protein-mediated cytoadherence to microvasculature" BROAD []
is_a: GO:0044406 ! adhesion to host

[Term]
id: GO:0020036
name: Maurer's cleft
namespace: cellular_component
def: "A disk-like structure that appears at the periphery of a red blood cell infected by an apicomplexan parasite, characterized by a translucent lumen and an electron-dense coat of variable thickness; often appears to be tethered to the host cell membrane by fibrous connections with the erythrocyte cytoskeleton." [PMID:16705161]
synonym: "Maurers cleft" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0020037
name: heme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [ChEBI:30413, GOC:ai]
subset: gosubset_prok
synonym: "haem binding" EXACT []
is_a: GO:0005506 ! iron ion binding
is_a: GO:0046906 ! tetrapyrrole binding

[Term]
id: GO:0020038
name: subpellicular network
namespace: cellular_component
def: "A mechanically stable cytoskeletal structure associated with the cytoplasmic face of the pellicle and surrounding the microtubule-based cytoskeleton." [PMID:11420112]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0020039 ! pellicle

[Term]
id: GO:0020039
name: pellicle
namespace: cellular_component
def: "The structure enclosing an apicomplexan parasite cell; consists of the cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles." [GOC:mah, GOC:mb]
is_a: GO:0044464 ! cell part

[Term]
id: GO:0021501
name: prechordal plate formation
namespace: biological_process
def: "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0021502
name: neural fold elevation formation
namespace: biological_process
def: "The process by which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15806586]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0001842 ! neural fold formation

[Term]
id: GO:0021503
name: neural fold bending
namespace: biological_process
def: "The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15806586]
comment: This term was added by GO_REF:0000021.
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0001842 ! neural fold formation

[Term]
id: GO:0021504
name: neural fold hinge point formation
namespace: biological_process
def: "The formation of the median and lateral hinge points in the neural folds. These are created by apical constriction and basal expansion of the underlying neural cells. The median hinge point extends for the entire length of the neural tube, and the lateral hinge points do not form in the spinal cord region of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:13679871, PMID:15806586]
comment: This term was added by GO_REF:0000021.
synonym: "neural fold furrowing" NARROW [GOC:cls]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021503 ! neural fold bending

[Term]
id: GO:0021505
name: neural fold folding
namespace: biological_process
def: "The process of folding the neuroepithelium around the medial hinge point to create the neural elevations, and around the lateral hinge points to produce convergence of the folds." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:13679871, PMID:15806586]
comment: This term was added by GO_REF:0000021.
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0021503 ! neural fold bending

[Term]
id: GO:0021506
name: anterior neuropore closure
namespace: biological_process
def: "The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0021995 ! neuropore closure

[Term]
id: GO:0021507
name: posterior neuropore closure
namespace: biological_process
def: "The joining together of the neural folds of the caudal opening of the neural tube. The posterior neuropore appears before the process of neural tube closure is complete." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0021995 ! neuropore closure

[Term]
id: GO:0021508
name: floor plate formation
namespace: biological_process
def: "The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007418 ! ventral midline development
relationship: part_of GO:0021990 ! neural plate formation

[Term]
id: GO:0021509
name: roof plate formation
namespace: biological_process
def: "The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15936325]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0001841 ! neural tube formation

[Term]
id: GO:0021510
name: spinal cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0021511
name: spinal cord patterning
namespace: biological_process
def: "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0021510 ! spinal cord development

[Term]
id: GO:0021512
name: spinal cord anterior/posterior patterning
namespace: biological_process
def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "spinal cord anterior-posterior patterning" EXACT []
synonym: "spinal cord rostrocaudal patterning" RELATED [GOC:dph]
is_a: GO:0009952 ! anterior/posterior pattern formation
relationship: part_of GO:0021511 ! spinal cord patterning

[Term]
id: GO:0021513
name: spinal cord dorsal/ventral patterning
namespace: biological_process
def: "The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "spinal cord dorsal-ventral patterning" EXACT [GOC:mah]
synonym: "spinal cord dorsal-ventral patterning" EXACT []
synonym: "spinal cord dorsoventral patterning" EXACT [GOC:mah]
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0021511 ! spinal cord patterning

[Term]
id: GO:0021514
name: ventral spinal cord interneuron differentiation
namespace: biological_process
def: "The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021517 ! ventral spinal cord development

[Term]
id: GO:0021515
name: cell differentiation in spinal cord
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021510 ! spinal cord development

[Term]
id: GO:0021516
name: dorsal spinal cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11179871]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021510 ! spinal cord development

[Term]
id: GO:0021517
name: ventral spinal cord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021510 ! spinal cord development

[Term]
id: GO:0021518
name: spinal cord commissural neuron specification
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into a commissural neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048665 ! neuron fate specification
relationship: part_of GO:0021528 ! commissural neuron differentiation in the spinal cord

[Term]
id: GO:0021519
name: spinal cord association neuron specification
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into an association neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048665 ! neuron fate specification
relationship: part_of GO:0021527 ! spinal cord association neuron differentiation

[Term]
id: GO:0021520
name: spinal cord motor neuron cell fate specification
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048665 ! neuron fate specification
relationship: part_of GO:0021522 ! spinal cord motor neuron differentiation

[Term]
id: GO:0021521
name: ventral spinal cord interneuron specification
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048665 ! neuron fate specification
relationship: part_of GO:0060579 ! ventral spinal cord interneuron fate commitment

[Term]
id: GO:0021522
name: spinal cord motor neuron differentiation
namespace: biological_process
def: "The process whereby neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021517 ! ventral spinal cord development

[Term]
id: GO:0021523
name: somatic motor neuron differentiation
namespace: biological_process
def: "The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021522 ! spinal cord motor neuron differentiation

[Term]
id: GO:0021524
name: visceral motor neuron differentiation
namespace: biological_process
def: "The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021522 ! spinal cord motor neuron differentiation

[Term]
id: GO:0021525
name: lateral motor column neuron differentiation
namespace: biological_process
def: "The process whereby differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021523 ! somatic motor neuron differentiation

[Term]
id: GO:0021526
name: medial motor column neuron differentiation
namespace: biological_process
def: "The process whereby differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021523 ! somatic motor neuron differentiation

[Term]
id: GO:0021527
name: spinal cord association neuron differentiation
namespace: biological_process
def: "The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "spinal cord dorsal interneuron differentiation" EXACT [GOC:dph]
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021516 ! dorsal spinal cord development

[Term]
id: GO:0021528
name: commissural neuron differentiation in the spinal cord
namespace: biological_process
def: "The process whereby neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of commissural neurons. Commissural neurons in both vertebrates and invertebrates transfer information from one side of their bodies to the other through the midline. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0021529
name: spinal cord oligodendrocyte cell differentiation
namespace: biological_process
def: "The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0021530
name: spinal cord oligodendrocyte cell fate specification
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021778 ! oligodendrocyte cell fate specification
relationship: part_of GO:0021529 ! spinal cord oligodendrocyte cell differentiation

[Term]
id: GO:0021531
name: radial glial cell differentiation in spinal cord
namespace: biological_process
def: "The process whereby neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16185248]
comment: This term was added by GO_REF:0000021.
is_a: GO:0010001 ! glial cell differentiation
is_a: GO:0021515 ! cell differentiation in spinal cord
is_a: GO:0060019 ! radial glial cell differentiation

[Term]
id: GO:0021532
name: neural tube patterning
namespace: biological_process
def: "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0021915 ! neural tube development

[Term]
id: GO:0021533
name: cell differentiation in hindbrain
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021534
name: cell proliferation in hindbrain
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021535
name: cell migration in hindbrain
namespace: biological_process
def: "The orderly movement of a cell that will reside in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021536
name: diencephalon development
namespace: biological_process
def: "The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021537
name: telencephalon development
namespace: biological_process
def: "The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021538
name: epithalamus development
namespace: biological_process
def: "The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021536 ! diencephalon development

[Term]
id: GO:0021539
name: subthalamus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "ventral thalamus development" RELATED [GOC:cls]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021536 ! diencephalon development

[Term]
id: GO:0021540
name: corpus callosum morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the corpus callosum are generated and organized. Morphogenesis pertains to the creation of form. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis
relationship: part_of GO:0022038 ! corpus callosum development

[Term]
id: GO:0021541
name: ammon gyrus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "Ammon's horn development" RELATED [GOC:cls]
synonym: "cornu ammonis development" RELATED [GOC:cls]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021766 ! hippocampus development

[Term]
id: GO:0021542
name: dentate gyrus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021766 ! hippocampus development

[Term]
id: GO:0021543
name: pallium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0021544
name: subpallium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0021545
name: cranial nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021675 ! nerve development

[Term]
id: GO:0021546
name: rhombomere development
namespace: biological_process
def: "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021547
name: midbrain-hindbrain boundary initiation
namespace: biological_process
def: "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jic, GOC:mtg_15jun06, PMID:15541513]
comment: This term was added by GO_REF:0000021.
synonym: "isthmus biosynthesis" RELATED [GOC:cls]
synonym: "isthmus formation" RELATED [GOC:cls]
synonym: "MHB biosynthesis" EXACT [GOC:cls]
synonym: "MHB formation" EXACT [GOC:cls]
synonym: "midbrain-hindbrain boundary biosynthesis" EXACT [GOC:cls]
synonym: "midbrain-hindbrain boundary formation" EXACT [GOC:cls]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization
relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development

[Term]
id: GO:0021548
name: pons development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0022037 ! metencephalon development

[Term]
id: GO:0021549
name: cerebellum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0022037 ! metencephalon development

[Term]
id: GO:0021550
name: medulla oblongata development
namespace: biological_process
def: "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "medulla development" RELATED [GOC:cls]
synonym: "myelencephalon development" RELATED [GOC:cls]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021551
name: central nervous system morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the central nervous system is generated and organized. Morphogenesis pertains to the creation of form. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0582227089]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0021552
name: midbrain-hindbrain boundary structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15541513]
comment: This term was added by GO_REF:0000021.
synonym: "isthmus structural organization" RELATED [GOC:cls]
synonym: "MHB structural organization" EXACT [GOC:cls]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021555 ! midbrain-hindbrain boundary morphogenesis

[Term]
id: GO:0021553
name: olfactory nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN 1 development" RELATED [GOC:cls]
synonym: "cranial nerve 1 development" EXACT [GOC:cls]
synonym: "cranial nerve I development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021554
name: optic nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN II development" RELATED [GOC:cls]
synonym: "cranial nerve 2 development" EXACT [GOC:cls]
synonym: "cranial nerve II development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021555
name: midbrain-hindbrain boundary morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. Morphogenesis pertains to the creation of form. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15541513]
comment: This term was added by GO_REF:0000021.
synonym: "isthmus morphogenesis" EXACT [GOC:cls]
synonym: "MHB morphogenesis" EXACT [GOC:cls]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development

[Term]
id: GO:0021556
name: central nervous system formation
namespace: biological_process
def: "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0582227089]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021551 ! central nervous system morphogenesis

[Term]
id: GO:0021557
name: oculomotor nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN III development" RELATED [GOC:cls]
synonym: "cranial nerve 3 development" EXACT [GOC:cls]
synonym: "cranial nerve III development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development
relationship: part_of GO:0021783 ! preganglionic parasympathetic nervous system development

[Term]
id: GO:0021558
name: trochlear nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IV development" RELATED [GOC:cls]
synonym: "cranial nerve 4 development" EXACT [GOC:cls]
synonym: "cranial nerve IV development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021559
name: trigeminal nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN V development" RELATED [GOC:cls]
synonym: "cranial nerve 5 development" EXACT [GOC:cls]
synonym: "cranial nerve V development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021560
name: abducens nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the abducens nerve over time, from its formation to the mature structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VI development" RELATED [GOC:cls]
synonym: "cranial nerve 6 development" EXACT [GOC:cls]
synonym: "cranial nerve VI development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021561
name: facial nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VII development" RELATED [GOC:cls]
synonym: "cranial nerve 7 development" EXACT [GOC:cls]
synonym: "cranial nerve VII development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development
relationship: part_of GO:0021783 ! preganglionic parasympathetic nervous system development

[Term]
id: GO:0021562
name: vestibulocochlear nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "acoustic nerve development" EXACT [PMID:11533729]
synonym: "CN VIII development" EXACT [GOC:cls]
synonym: "cranial nerve 8 development" EXACT [GOC:cls]
synonym: "cranial nerve VIII development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021563
name: glossopharyngeal nerve development
namespace: biological_process
def: "Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IX development" RELATED [GOC:cls]
synonym: "cranial nerve 9 development" EXACT [GOC:cls]
synonym: "cranial nerve IX development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021564
name: vagus nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN X development" RELATED [GOC:cls]
synonym: "cranial nerve 10 development" RELATED [GOC:cls]
synonym: "cranial nerve X development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development
relationship: part_of GO:0021783 ! preganglionic parasympathetic nervous system development

[Term]
id: GO:0021565
name: accessory nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XI development" RELATED [GOC:cls]
synonym: "cranial nerve 11 development" RELATED [GOC:cls]
synonym: "cranial nerve XI development" EXACT [GOC:cls]
synonym: "spinal accessory nerve development" EXACT [PMID:11533729]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021566
name: hypoglossal nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XII development" RELATED [GOC:cls]
synonym: "cranial nerve 12 development" RELATED [GOC:cls]
synonym: "cranial nerve XII development" EXACT [GOC:cls]
is_a: GO:0021545 ! cranial nerve development

[Term]
id: GO:0021567
name: rhombomere 1 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021568
name: rhombomere 2 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021569
name: rhombomere 3 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021570
name: rhombomere 4 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021571
name: rhombomere 5 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021572
name: rhombomere 6 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021573
name: rhombomere 7 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 7 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021574
name: rhombomere 8 development
namespace: biological_process
def: "The process whose specific outcome is the progression of rhombomere 8 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021546 ! rhombomere development

[Term]
id: GO:0021575
name: hindbrain morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the hindbrain is generated and organized. Morphogenesis pertains to the creation of form. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "rhombencephalon morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021576
name: hindbrain formation
namespace: biological_process
def: "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021575 ! hindbrain morphogenesis

[Term]
id: GO:0021577
name: hindbrain structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021575 ! hindbrain morphogenesis

[Term]
id: GO:0021578
name: hindbrain maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0021626 ! central nervous system maturation
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021579
name: medulla oblongata morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the medulla oblongata is generated and organized. Morphogenesis pertains to the creation of form. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "medulla morphogenesis" RELATED []
synonym: "myelencephalon morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021550 ! medulla oblongata development
relationship: part_of GO:0021575 ! hindbrain morphogenesis

[Term]
id: GO:0021580
name: medulla oblongata formation
namespace: biological_process
def: "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "medulla biosynthesis" RELATED []
synonym: "medulla formation" RELATED []
synonym: "myelencephalon biosynthesis" RELATED []
synonym: "myelencephalon formation" RELATED []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021576 ! hindbrain formation
relationship: part_of GO:0021579 ! medulla oblongata morphogenesis

[Term]
id: GO:0021581
name: medulla oblongata structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the medulla oblongata. This process pertains to the physical shaping of a rudimentary structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "medulla structural maturation" RELATED []
synonym: "myelencephalon structural maturation" RELATED []
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021577 ! hindbrain structural organization
relationship: part_of GO:0021579 ! medulla oblongata morphogenesis

[Term]
id: GO:0021582
name: medulla oblongata maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "medulla maturation" RELATED []
synonym: "myelencephalon maturation" RELATED []
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0021550 ! medulla oblongata development
relationship: part_of GO:0021578 ! hindbrain maturation

[Term]
id: GO:0021583
name: pons morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the pons is generated and organized. Morphogenesis pertains to the creation of form. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021548 ! pons development
relationship: part_of GO:0021575 ! hindbrain morphogenesis

[Term]
id: GO:0021584
name: pons formation
namespace: biological_process
def: "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021576 ! hindbrain formation
relationship: part_of GO:0021583 ! pons morphogenesis

[Term]
id: GO:0021585
name: pons structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the pons. This process pertains to the physical shaping of a rudimentary structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021577 ! hindbrain structural organization
relationship: part_of GO:0021583 ! pons morphogenesis

[Term]
id: GO:0021586
name: pons maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0021548 ! pons development
relationship: part_of GO:0021578 ! hindbrain maturation

[Term]
id: GO:0021587
name: cerebellum morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the cerebellum is generated and organized. Morphogenesis pertains to the creation of form. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021549 ! cerebellum development
relationship: part_of GO:0021575 ! hindbrain morphogenesis

[Term]
id: GO:0021588
name: cerebellum formation
namespace: biological_process
def: "The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021576 ! hindbrain formation
relationship: part_of GO:0021587 ! cerebellum morphogenesis

[Term]
id: GO:0021589
name: cerebellum structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021577 ! hindbrain structural organization
relationship: part_of GO:0021587 ! cerebellum morphogenesis

[Term]
id: GO:0021590
name: cerebellum maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0021549 ! cerebellum development
relationship: part_of GO:0021578 ! hindbrain maturation

[Term]
id: GO:0021591
name: ventricular system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048731 ! system development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0021592
name: fourth ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0683400078]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021591 ! ventricular system development
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0021593
name: rhombomere morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the rhombomere is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021546 ! rhombomere development

[Term]
id: GO:0021594
name: rhombomere formation
namespace: biological_process
def: "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021593 ! rhombomere morphogenesis

[Term]
id: GO:0021595
name: rhombomere structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the rhombomere structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021593 ! rhombomere morphogenesis

[Term]
id: GO:0021597
name: central nervous system structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the central nervous system structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0582227089]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021551 ! central nervous system morphogenesis

[Term]
id: GO:0021598
name: abducens nerve morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the abducens nerve is generated and organized. Morphogenesis pertains to the creation of form. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VI development" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021560 ! abducens nerve development

[Term]
id: GO:0021599
name: abducens nerve formation
namespace: biological_process
def: "The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VI biosynthesis" RELATED []
synonym: "CN VI formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021598 ! abducens nerve morphogenesis

[Term]
id: GO:0021600
name: abducens nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the abducens nerve. This process pertains to the physical shaping of a rudimentary structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VI structural organization" RELATED []
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021598 ! abducens nerve morphogenesis

[Term]
id: GO:0021601
name: abducens nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the abducens nerve to attain its fully functional state. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VI maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021560 ! abducens nerve development

[Term]
id: GO:0021602
name: cranial nerve morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the cranial nerves are generated and organized. Morphogenesis pertains to the creation of form. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021545 ! cranial nerve development

[Term]
id: GO:0021603
name: cranial nerve formation
namespace: biological_process
def: "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021602 ! cranial nerve morphogenesis

[Term]
id: GO:0021604
name: cranial nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021602 ! cranial nerve morphogenesis

[Term]
id: GO:0021605
name: cranial nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021682 ! nerve maturation
relationship: part_of GO:0021545 ! cranial nerve development

[Term]
id: GO:0021606
name: accessory nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XI maturation" RELATED []
synonym: "spinal accessory nerve maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021565 ! accessory nerve development

[Term]
id: GO:0021607
name: accessory nerve morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the accessory nerve is generated and organized. Morphogenesis pertains to the creation of form. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XI morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021565 ! accessory nerve development

[Term]
id: GO:0021608
name: accessory nerve formation
namespace: biological_process
def: "The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XI biosynthesis" RELATED []
synonym: "CN XI formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021607 ! accessory nerve morphogenesis

[Term]
id: GO:0021609
name: accessory nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the accessory nerve This process pertains to the physical shaping of a rudimentary structure. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XI structural organization" RELATED []
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021607 ! accessory nerve morphogenesis

[Term]
id: GO:0021610
name: facial nerve morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the facial nerve is generated and organized. Morphogenesis pertains to the creation of form. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VII morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021561 ! facial nerve development

[Term]
id: GO:0021611
name: facial nerve formation
namespace: biological_process
def: "The process that gives rise to the facial nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VII biosynthesis" RELATED []
synonym: "CN VII formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021610 ! facial nerve morphogenesis

[Term]
id: GO:0021612
name: facial nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VII structural organization" RELATED []
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021610 ! facial nerve morphogenesis

[Term]
id: GO:0021613
name: facial nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the facial nerve to attain its fully functional state. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VII maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021561 ! facial nerve development

[Term]
id: GO:0021614
name: glossopharyngeal nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IX maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021563 ! glossopharyngeal nerve development

[Term]
id: GO:0021615
name: glossopharyngeal nerve morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the glossopharyngeal nerve is generated and organized. Morphogenesis pertains to the creation of form. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IX morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021563 ! glossopharyngeal nerve development

[Term]
id: GO:0021616
name: glossopharyngeal nerve formation
namespace: biological_process
def: "The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IX biosynthesis" RELATED []
synonym: "CN IX formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021615 ! glossopharyngeal nerve morphogenesis

[Term]
id: GO:0021617
name: glossopharyngeal nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the glossopharyngeal nerve. This process pertains to the physical shaping of a rudimentary structure. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IX structural organization" RELATED []
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021615 ! glossopharyngeal nerve morphogenesis

[Term]
id: GO:0021618
name: hypoglossal nerve morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the hypoglossal nerve is generated and organized. Morphogenesis pertains to the creation of form. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XII morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021566 ! hypoglossal nerve development

[Term]
id: GO:0021619
name: hypoglossal nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XII maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021566 ! hypoglossal nerve development

[Term]
id: GO:0021620
name: hypoglossal nerve formation
namespace: biological_process
def: "The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XII biosynthesis" RELATED []
synonym: "CN XII formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis

[Term]
id: GO:0021621
name: hypoglossal nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the hypoglossal nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN XII structural organization" RELATED []
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis

[Term]
id: GO:0021622
name: oculomotor nerve morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the oculomotor nerve is generated and organized. Morphogenesis pertains to the creation of form. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN III morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021557 ! oculomotor nerve development

[Term]
id: GO:0021623
name: oculomotor nerve formation
namespace: biological_process
def: "The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN III biosynthesis" RELATED []
synonym: "CN III formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021622 ! oculomotor nerve morphogenesis

[Term]
id: GO:0021624
name: oculomotor nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN III structural organization" RELATED []
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021622 ! oculomotor nerve morphogenesis

[Term]
id: GO:0021625
name: oculomotor nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN III maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021557 ! oculomotor nerve development

[Term]
id: GO:0021626
name: central nervous system maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0582227089]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0021627
name: olfactory nerve morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the olfactory nerve is generated and organized. Morphogenesis pertains to the creation of form. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN I morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021553 ! olfactory nerve development

[Term]
id: GO:0021628
name: olfactory nerve formation
namespace: biological_process
def: "The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN I biosynthesis" RELATED []
synonym: "CN I formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021627 ! olfactory nerve morphogenesis

[Term]
id: GO:0021629
name: olfactory nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN I structural organization" RELATED []
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021627 ! olfactory nerve morphogenesis

[Term]
id: GO:0021630
name: olfactory nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "CN I maturation" EXACT []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021553 ! olfactory nerve development

[Term]
id: GO:0021631
name: optic nerve morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the optic nerve is generated and organized. Morphogenesis pertains to the creation of form. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN II morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021554 ! optic nerve development

[Term]
id: GO:0021632
name: optic nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the optic nerve to attain its fully functional state. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN II maturation" EXACT []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021554 ! optic nerve development

[Term]
id: GO:0021633
name: optic nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN II structural organization" RELATED []
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021631 ! optic nerve morphogenesis

[Term]
id: GO:0021634
name: optic nerve formation
namespace: biological_process
def: "The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN II biosynthesis" RELATED []
synonym: "CN II formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021631 ! optic nerve morphogenesis

[Term]
id: GO:0021635
name: trigeminal nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN V maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021559 ! trigeminal nerve development

[Term]
id: GO:0021636
name: trigeminal nerve morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the trigeminal nerve is generated and organized. Morphogenesis pertains to the creation of form. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN V morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021559 ! trigeminal nerve development

[Term]
id: GO:0021637
name: trigeminal nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN V structural organization" RELATED []
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis

[Term]
id: GO:0021638
name: trigeminal nerve formation
namespace: biological_process
def: "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN V biosynthesis" RELATED []
synonym: "CN V formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis

[Term]
id: GO:0021639
name: trochlear nerve morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the trochlear nerve is generated and organized. Morphogenesis pertains to the creation of form. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CH IV morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021558 ! trochlear nerve development

[Term]
id: GO:0021640
name: trochlear nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trochlear nerve to attain its fully functional state. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IV maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021558 ! trochlear nerve development

[Term]
id: GO:0021641
name: trochlear nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the trochlear nerve. This process pertains to the physical shaping of a rudimentary structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IV structural organization" RELATED []
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021639 ! trochlear nerve morphogenesis

[Term]
id: GO:0021642
name: trochlear nerve formation
namespace: biological_process
def: "The process that gives rise to the trochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN IV biosynthesis" RELATED []
synonym: "CN IV formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021639 ! trochlear nerve morphogenesis

[Term]
id: GO:0021643
name: vagus nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN X maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021564 ! vagus nerve development

[Term]
id: GO:0021644
name: vagus nerve morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the vagus nerve is generated and organized. Morphogenesis pertains to the creation of form. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN X morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021564 ! vagus nerve development

[Term]
id: GO:0021645
name: vagus nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN X structural organization" RELATED []
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021644 ! vagus nerve morphogenesis

[Term]
id: GO:0021646
name: vagus nerve formation
namespace: biological_process
def: "The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN X biosynthesis" RELATED []
synonym: "CN X formation" RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021644 ! vagus nerve morphogenesis

[Term]
id: GO:0021647
name: vestibulocochlear nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "auditory nerve maturation" RELATED []
synonym: "CN VIII maturation" RELATED []
is_a: GO:0021605 ! cranial nerve maturation
relationship: part_of GO:0021562 ! vestibulocochlear nerve development

[Term]
id: GO:0021648
name: vestibulocochlear nerve morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the vestibulocochlear nerve is generated and organized. Morphogenesis pertains to the creation of form. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VIII morphogenesis" RELATED []
is_a: GO:0021602 ! cranial nerve morphogenesis
relationship: part_of GO:0021562 ! vestibulocochlear nerve development

[Term]
id: GO:0021649
name: vestibulocochlear nerve structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VII structural organization" RELATED []
is_a: GO:0021604 ! cranial nerve structural organization
relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis

[Term]
id: GO:0021650
name: vestibulocochlear nerve formation
namespace: biological_process
def: "The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "CN VII formation " RELATED []
is_a: GO:0021603 ! cranial nerve formation
relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis

[Term]
id: GO:0021651
name: rhombomere 1 morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of rhombomere 1 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021567 ! rhombomere 1 development

[Term]
id: GO:0021652
name: rhombomere 1 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis

[Term]
id: GO:0021653
name: rhombomere 1 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 1. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis

[Term]
id: GO:0021654
name: rhombomere boundary formation
namespace: biological_process
def: "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0021594 ! rhombomere formation

[Term]
id: GO:0021655
name: rhombomere 2 morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of rhombomere 2 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021568 ! rhombomere 2 development

[Term]
id: GO:0021656
name: rhombomere 2 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 2. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021655 ! rhombomere 2 morphogenesis

[Term]
id: GO:0021657
name: rhombomere 2 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 2. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021655 ! rhombomere 2 morphogenesis

[Term]
id: GO:0021658
name: rhombomere 3 morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of rhombomere 3 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021569 ! rhombomere 3 development

[Term]
id: GO:0021659
name: rhombomere 3 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021658 ! rhombomere 3 morphogenesis

[Term]
id: GO:0021660
name: rhombomere 3 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021658 ! rhombomere 3 morphogenesis

[Term]
id: GO:0021661
name: rhombomere 4 morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of rhombomere 4 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021570 ! rhombomere 4 development

[Term]
id: GO:0021662
name: rhombomere 4 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 4. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021661 ! rhombomere 4 morphogenesis

[Term]
id: GO:0021663
name: rhombomere 4 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 4. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021661 ! rhombomere 4 morphogenesis

[Term]
id: GO:0021664
name: rhombomere 5 morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of rhombomere 5 are generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021571 ! rhombomere 5 development

[Term]
id: GO:0021665
name: rhombomere 5 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021664 ! rhombomere 5 morphogenesis

[Term]
id: GO:0021666
name: rhombomere 5 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021664 ! rhombomere 5 morphogenesis

[Term]
id: GO:0021667
name: rhombomere 6 morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of rhombomere 6 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021572 ! rhombomere 6 development

[Term]
id: GO:0021668
name: rhombomere 6 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 6. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021667 ! rhombomere 6 morphogenesis

[Term]
id: GO:0021669
name: rhombomere 6 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 6. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021667 ! rhombomere 6 morphogenesis

[Term]
id: GO:0021670
name: lateral ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0683400078]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021537 ! telencephalon development
relationship: part_of GO:0021591 ! ventricular system development

[Term]
id: GO:0021671
name: rhombomere 7 morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of rhombomere 7 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021573 ! rhombomere 7 development

[Term]
id: GO:0021672
name: rhombomere 7 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 7. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021671 ! rhombomere 7 morphogenesis

[Term]
id: GO:0021673
name: rhombomere 7 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 7. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021671 ! rhombomere 7 morphogenesis

[Term]
id: GO:0021674
name: rhombomere 8 morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of rhombomere 8 is generated and organized. Morphogenesis pertains to the creation of form. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021593 ! rhombomere morphogenesis
relationship: part_of GO:0021574 ! rhombomere 8 development

[Term]
id: GO:0021675
name: nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0021676
name: rhombomere 8 structural organization
namespace: biological_process
def: "The process that contributes to creating the structural organization of rhombomere 8. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021595 ! rhombomere structural organization
relationship: part_of GO:0021674 ! rhombomere 8 morphogenesis

[Term]
id: GO:0021677
name: rhombomere 8 formation
namespace: biological_process
def: "The process that gives rise to rhombomere 8. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021594 ! rhombomere formation
relationship: part_of GO:0021674 ! rhombomere 8 morphogenesis

[Term]
id: GO:0021678
name: third ventricle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0683400078]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021591 ! ventricular system development

[Term]
id: GO:0021679
name: cerebellar molecular layer development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021695 ! cerebellar cortex development

[Term]
id: GO:0021680
name: cerebellar Purkinje cell layer development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021695 ! cerebellar cortex development

[Term]
id: GO:0021681
name: cerebellar granular layer development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021695 ! cerebellar cortex development

[Term]
id: GO:0021682
name: nerve maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0021675 ! nerve development

[Term]
id: GO:0021683
name: cerebellar granular layer morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the cerebellar granular layer is generated and organized. Morphogenesis pertains to the creation of form. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021681 ! cerebellar granular layer development
relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis

[Term]
id: GO:0021684
name: cerebellar granular layer formation
namespace: biological_process
def: "The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021683 ! cerebellar granular layer morphogenesis
relationship: part_of GO:0021697 ! cerebellar cortex formation

[Term]
id: GO:0021685
name: cerebellar granular layer structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021683 ! cerebellar granular layer morphogenesis
relationship: part_of GO:0021698 ! cerebellar cortex structural organization

[Term]
id: GO:0021686
name: cerebellar granular layer maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0021681 ! cerebellar granular layer development
relationship: part_of GO:0021699 ! cerebellar cortex maturation

[Term]
id: GO:0021687
name: cerebellar molecular layer morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the cerebellar molecular layer is generated and organized. Morphogenesis pertains to the creation of form. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021679 ! cerebellar molecular layer development
relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis

[Term]
id: GO:0021688
name: cerebellar molecular layer formation
namespace: biological_process
def: "The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021687 ! cerebellar molecular layer morphogenesis
relationship: part_of GO:0021697 ! cerebellar cortex formation

[Term]
id: GO:0021689
name: cerebellar molecular layer structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cerebellar molecular layer. This process pertains to the physical shaping of a rudimentary structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021687 ! cerebellar molecular layer morphogenesis
relationship: part_of GO:0021698 ! cerebellar cortex structural organization

[Term]
id: GO:0021690
name: cerebellar molecular layer maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0021679 ! cerebellar molecular layer development
relationship: part_of GO:0021699 ! cerebellar cortex maturation

[Term]
id: GO:0021691
name: cerebellar Purkinje cell layer maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021700 ! developmental maturation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021680 ! cerebellar Purkinje cell layer development
relationship: part_of GO:0021699 ! cerebellar cortex maturation

[Term]
id: GO:0021692
name: cerebellar Purkinje cell layer morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. Morphogenesis pertains to the creation of form. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021680 ! cerebellar Purkinje cell layer development
relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis

[Term]
id: GO:0021693
name: cerebellar Purkinje cell layer structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021692 ! cerebellar Purkinje cell layer morphogenesis
relationship: part_of GO:0021698 ! cerebellar cortex structural organization

[Term]
id: GO:0021694
name: cerebellar Purkinje cell layer formation
namespace: biological_process
def: "The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021692 ! cerebellar Purkinje cell layer morphogenesis
relationship: part_of GO:0021697 ! cerebellar cortex formation

[Term]
id: GO:0021695
name: cerebellar cortex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0021696
name: cerebellar cortex morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the cranial nerves are generated and organized. Morphogenesis pertains to the creation of form. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021587 ! cerebellum morphogenesis
relationship: part_of GO:0021695 ! cerebellar cortex development

[Term]
id: GO:0021697
name: cerebellar cortex formation
namespace: biological_process
def: "The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis

[Term]
id: GO:0021698
name: cerebellar cortex structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis

[Term]
id: GO:0021699
name: cerebellar cortex maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0021590 ! cerebellum maturation
relationship: part_of GO:0021695 ! cerebellar cortex development

[Term]
id: GO:0021700
name: developmental maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0021701
name: cerebellar Golgi cell differentiation
namespace: biological_process
def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021684 ! cerebellar granular layer formation

[Term]
id: GO:0021702
name: cerebellar Purkinje cell differentiation
namespace: biological_process
def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021694 ! cerebellar Purkinje cell layer formation

[Term]
id: GO:0021703
name: locus ceruleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "locus caeruleus development" EXACT []
synonym: "locus coeruleus development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021704
name: locus ceruleus morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the locus ceruleus is generated and organized. Morphogenesis pertains to the creation of form. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021583 ! pons morphogenesis
relationship: part_of GO:0021703 ! locus ceruleus development

[Term]
id: GO:0021705
name: locus ceruleus formation
namespace: biological_process
def: "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021584 ! pons formation
relationship: part_of GO:0021704 ! locus ceruleus morphogenesis

[Term]
id: GO:0021706
name: locus ceruleus maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0021586 ! pons maturation
relationship: part_of GO:0021703 ! locus ceruleus development

[Term]
id: GO:0021707
name: cerebellar granule cell differentiation
namespace: biological_process
def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021684 ! cerebellar granular layer formation

[Term]
id: GO:0021708
name: Lugaro cell differentiation
namespace: biological_process
def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021697 ! cerebellar cortex formation

[Term]
id: GO:0021709
name: cerebellar basket cell differentiation
namespace: biological_process
def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021688 ! cerebellar molecular layer formation

[Term]
id: GO:0021710
name: cerebellar stellate cell differentiation
namespace: biological_process
def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021688 ! cerebellar molecular layer formation

[Term]
id: GO:0021711
name: cerebellar unipolar brush cell differentiation
namespace: biological_process
def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021684 ! cerebellar granular layer formation

[Term]
id: GO:0021712
name: candelabrum cell differentiation
namespace: biological_process
def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature candelabrum cell. Differentiation includes the processes involved in commitment of a neuroblast to a candelabrum cell fate. A candelabrum cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021694 ! cerebellar Purkinje cell layer formation

[Term]
id: GO:0021713
name: inferior olivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inferior olivary nucleus over time, from its formation to the mature structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "inferior olive development" RELATED []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021714
name: inferior olivary nucleus morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the inferior olivary nucleus is generated and organized. Morphogenesis pertains to the creation of form. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "inferior olive morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021579 ! medulla oblongata morphogenesis
relationship: part_of GO:0021713 ! inferior olivary nucleus development

[Term]
id: GO:0021715
name: inferior olivary nucleus formation
namespace: biological_process
def: "The process that gives rise to the inferior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "inferior olive biosynthesis" RELATED []
synonym: "inferior olive formation" RELATED []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021580 ! medulla oblongata formation
relationship: part_of GO:0021714 ! inferior olivary nucleus morphogenesis

[Term]
id: GO:0021716
name: inferior olivary nucleus structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the inferior olivary nucleus structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "inferior olive structural organization" RELATED []
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021581 ! medulla oblongata structural organization
relationship: part_of GO:0021714 ! inferior olivary nucleus morphogenesis

[Term]
id: GO:0021717
name: inferior olivary nucleus maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the inferior olivary nucleus to attain its fully functional state. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "inferior olive maturation" RELATED []
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0021582 ! medulla oblongata maturation
relationship: part_of GO:0021713 ! inferior olivary nucleus development

[Term]
id: GO:0021718
name: superior olivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "superior olive development" RELATED []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021719
name: superior olivary nucleus morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the superior olivary nucleus is generated and organized. Morphogenesis pertains to the creation of form. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "superior olive morphogenesis" RELATED []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021583 ! pons morphogenesis
relationship: part_of GO:0021718 ! superior olivary nucleus development

[Term]
id: GO:0021720
name: superior olivary nucleus formation
namespace: biological_process
def: "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021584 ! pons formation
relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis

[Term]
id: GO:0021721
name: superior olivary nucleus structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the superior olivary nucleus structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0021585 ! pons structural organization
relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis

[Term]
id: GO:0021722
name: superior olivary nucleus maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343]
comment: This term was added by GO_REF:0000021.
synonym: "superior olive maturation" RELATED []
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0021586 ! pons maturation
relationship: part_of GO:0021718 ! superior olivary nucleus development

[Term]
id: GO:0021723
name: rhombencephalic reticular formation development
namespace: biological_process
def: "The process whose specific outcome is the progression of the reticular formation over time, from its formation to the mature structure. The reticular formation is a series of brain nuclei located in the medulla oblongata." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021724
name: inferior raphe nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inferior raphe nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021723 ! rhombencephalic reticular formation development

[Term]
id: GO:0021725
name: superior raphe nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior raphe nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021723 ! rhombencephalic reticular formation development

[Term]
id: GO:0021726
name: lateral reticular nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral reticular nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021723 ! rhombencephalic reticular formation development

[Term]
id: GO:0021727
name: intermediate reticular formation development
namespace: biological_process
def: "The process whose specific outcome is the progression of the intermediate reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021723 ! rhombencephalic reticular formation development

[Term]
id: GO:0021728
name: inferior reticular formation development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inferior reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021723 ! rhombencephalic reticular formation development

[Term]
id: GO:0021729
name: superior reticular formation development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021723 ! rhombencephalic reticular formation development

[Term]
id: GO:0021730
name: trigeminal sensory nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the trigeminal sensory nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021. Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions from midbrain to spinal cord.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0021731
name: trigeminal motor nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the trigeminal motor nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021732
name: midbrain-hindbrain boundary maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15541513]
comment: This term was added by GO_REF:0000021.
synonym: "isthmus maturation" RELATED []
synonym: "MHB maturation" RELATED []
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development

[Term]
id: GO:0021735
name: dentate nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dentate nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0021736
name: globose nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the globose nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0021737
name: emboliform nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0021738
name: fastigial nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fastigial nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021549 ! cerebellum development

[Term]
id: GO:0021739
name: mesencephalic trigeminal nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesencephalic trigeminal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021730 ! trigeminal sensory nucleus development

[Term]
id: GO:0021740
name: pontine nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021. Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021730 ! trigeminal sensory nucleus development

[Term]
id: GO:0021741
name: spinal trigeminal nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the spinal trigeminal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021730 ! trigeminal sensory nucleus development

[Term]
id: GO:0021742
name: abducens nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021743
name: hypoglossal nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021744
name: dorsal motor nucleus of vagus nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021745
name: nucleus ambiguus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021746
name: solitary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the solitary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021550 ! medulla oblongata development

[Term]
id: GO:0021747
name: cochlear nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021748
name: dorsal cochlear nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021747 ! cochlear nucleus development

[Term]
id: GO:0021749
name: ventral cochlear nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021747 ! cochlear nucleus development

[Term]
id: GO:0021750
name: vestibular nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021751
name: salivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021752
name: inferior salivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inferior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021751 ! salivary nucleus development

[Term]
id: GO:0021753
name: superior salivary nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021751 ! salivary nucleus development

[Term]
id: GO:0021754
name: facial nucleus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021548 ! pons development

[Term]
id: GO:0021755
name: eurydendroid cell differentiation
namespace: biological_process
def: "The process whereby neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15892096]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021697 ! cerebellar cortex formation

[Term]
id: GO:0021756
name: striatum development
namespace: biological_process
def: "The progression of the striatum over time from its initial formation until its mature state. The striatum is a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021544 ! subpallium development

[Term]
id: GO:0021757
name: caudate nucleus development
namespace: biological_process
def: "The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021756 ! striatum development

[Term]
id: GO:0021758
name: putamen development
namespace: biological_process
def: "The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021756 ! striatum development

[Term]
id: GO:0021759
name: globus pallidus development
namespace: biological_process
def: "The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
synonym: "pallidum development" EXACT [PMID:16271465]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021536 ! diencephalon development

[Term]
id: GO:0021761
name: limbic system development
namespace: biological_process
def: "The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048731 ! system development
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021762
name: substantia nigra development
namespace: biological_process
def: "The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0838580343, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021539 ! subthalamus development

[Term]
id: GO:0021763
name: subthalamic nucleus development
namespace: biological_process
def: "The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
synonym: "corpus luysi development" RELATED []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021539 ! subthalamus development

[Term]
id: GO:0021764
name: amygdala development
namespace: biological_process
def: "The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021765
name: cingulate gyrus development
namespace: biological_process
def: "The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021766
name: hippocampus development
namespace: biological_process
def: "The progression of the hippocampus over time from its initial formation until its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021543 ! pallium development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021767
name: mammilary body development
namespace: biological_process
def: "The progression of the mammilary body over time from its initial formation until its mature state. The mammilary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
synonym: "mammillary body development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021536 ! diencephalon development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021768
name: nucleus accumbens development
namespace: biological_process
def: "The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
synonym: "accumbens nucleus development" EXACT [GOC:dgh]
synonym: "ventral striatum development" BROAD []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021756 ! striatum development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021769
name: orbitofrontal cortex development
namespace: biological_process
def: "The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021770
name: parahippocampal gyrus development
namespace: biological_process
def: "The progression of the parahippocampal gyrus over time from its initial formation until its mature state. The parahippocampal gyrus is a ridge in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
synonym: "hippocampal gyrus development" EXACT [GOC:dgh]
xref: Wikipedia:parahippocampal_gyrus
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021771
name: lateral geniculate nucleus development
namespace: biological_process
def: "The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
synonym: "LGN development" EXACT [GOC:dgh]
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0021794 ! thalamus development

[Term]
id: GO:0021772
name: olfactory bulb development
namespace: biological_process
def: "The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021988 ! olfactory lobe development

[Term]
id: GO:0021773
name: striatal medium spiny neuron differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021879 ! forebrain neuron differentiation
relationship: part_of GO:0021756 ! striatum development

[Term]
id: GO:0021774
name: retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:sdb_2009, GOC:tb, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "retinoic acid receptor signalling pathway involved in ventral spinal cord interneuron specification" EXACT []
is_a: GO:0060895 ! retinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning
relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification

[Term]
id: GO:0021775
name: smoothened signaling pathway involved in ventral spinal cord interneuron specification
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "smoothened signalling pathway involved in ventral spinal cord interneuron specification" EXACT []
is_a: GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning
relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification

[Term]
id: GO:0021776
name: smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
namespace: biological_process
def: "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15936325]
comment: This term was added by GO_REF:0000021.
synonym: "smoothened signalling pathway involved in spinal cord motor neuron cell fate specification" EXACT []
is_a: GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning
relationship: part_of GO:0021520 ! spinal cord motor neuron cell fate specification

[Term]
id: GO:0021777
name: BMP signaling pathway involved in spinal cord association neuron specification
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to its commitment to an association neuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12593981]
comment: This term was added by GO_REF:0000021.
synonym: "BMP signalling pathway involved in spinal cord association neuron specification" EXACT []
synonym: "bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT []
synonym: "bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT []
is_a: GO:0021919 ! BMP signaling pathway in spinal cord dorsal/ventral patterning
relationship: part_of GO:0021519 ! spinal cord association neuron specification

[Term]
id: GO:0021778
name: oligodendrocyte cell fate specification
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021780 ! glial cell fate specification
relationship: part_of GO:0021779 ! oligodendrocyte cell fate commitment

[Term]
id: GO:0021779
name: oligodendrocyte cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021781 ! glial cell fate commitment
is_a: GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0021780
name: glial cell fate specification
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0021781 ! glial cell fate commitment

[Term]
id: GO:0021781
name: glial cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a glial cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0010001 ! glial cell differentiation

[Term]
id: GO:0021782
name: glial cell development
namespace: biological_process
def: "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048468 ! cell development
relationship: part_of GO:0010001 ! glial cell differentiation

[Term]
id: GO:0021783
name: preganglionic parasympathetic nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the preganglionic portion of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048731 ! system development
relationship: part_of GO:0007417 ! central nervous system development
relationship: part_of GO:0048486 ! parasympathetic nervous system development

[Term]
id: GO:0021784
name: postganglionic parasympathetic nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048731 ! system development
relationship: part_of GO:0007422 ! peripheral nervous system development
relationship: part_of GO:0048486 ! parasympathetic nervous system development

[Term]
id: GO:0021785
name: branchiomotor neuron axon guidance
namespace: biological_process
def: "The process by which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
synonym: "BMN axon guidance" EXACT [PMID:14699587]
synonym: "branchial motor axon guidance" EXACT [PMID:14699587]
synonym: "special visceral motor neuron axon guidance" EXACT [PMID:14699587]
is_a: GO:0008045 ! motor axon guidance

[Term]
id: GO:0021786
name: branchiomotor neuron axon guidance in the neural tube
namespace: biological_process
def: "The process by which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021785 ! branchiomotor neuron axon guidance

[Term]
id: GO:0021787
name: chemorepulsion of branchiomotor neuron axon in neural tube
namespace: biological_process
def: "The process by which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
synonym: "negative chemotaxis of branchiomotor neuron axon in neural tube" EXACT [GOC:mah]
is_a: GO:0021786 ! branchiomotor neuron axon guidance in the neural tube
is_a: GO:0021793 ! chemorepulsion of branchiomotor axon

[Term]
id: GO:0021788
name: chemoattraction of branchiomotor neuron axon in neural tube
namespace: biological_process
def: "The process by which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
synonym: "positive chemotaxis of branchiomotor neuron axon in neural tube" EXACT [GOC:mah]
is_a: GO:0021786 ! branchiomotor neuron axon guidance in the neural tube
is_a: GO:0021792 ! chemoattraction of branchiomotor axon

[Term]
id: GO:0021789
name: branchiomotor neuron axon guidance in the branchial arch mesenchyme
namespace: biological_process
def: "The process by which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021785 ! branchiomotor neuron axon guidance

[Term]
id: GO:0021790
name: chemorepulsion of branchiomotor neuron axon in branchial arch mesenchyme
namespace: biological_process
def: "The process by which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
synonym: "negative chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme" EXACT [GOC:mah]
is_a: GO:0021789 ! branchiomotor neuron axon guidance in the branchial arch mesenchyme
is_a: GO:0021793 ! chemorepulsion of branchiomotor axon

[Term]
id: GO:0021791
name: chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme
namespace: biological_process
def: "The process by which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
synonym: "positive chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme" EXACT [GOC:mah]
is_a: GO:0021789 ! branchiomotor neuron axon guidance in the branchial arch mesenchyme
is_a: GO:0021792 ! chemoattraction of branchiomotor axon

[Term]
id: GO:0021792
name: chemoattraction of branchiomotor axon
namespace: biological_process
def: "The process by which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
synonym: "positive chemotaxis of branchiomotor axon" EXACT [GOC:mah]
is_a: GO:0050918 ! positive chemotaxis
is_a: GO:0070887 ! cellular response to chemical stimulus
relationship: part_of GO:0021785 ! branchiomotor neuron axon guidance

[Term]
id: GO:0021793
name: chemorepulsion of branchiomotor axon
namespace: biological_process
def: "The process by which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:14699587]
comment: This term was added by GO_REF:0000021.
synonym: "negative chemotaxis of branchiomotor axon" EXACT [GOC:mah]
is_a: GO:0050919 ! negative chemotaxis
is_a: GO:0070887 ! cellular response to chemical stimulus
relationship: part_of GO:0021785 ! branchiomotor neuron axon guidance

[Term]
id: GO:0021794
name: thalamus development
namespace: biological_process
def: "The process by which the thalamus changes over time, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021536 ! diencephalon development

[Term]
id: GO:0021795
name: cerebral cortex cell migration
namespace: biological_process
def: "The orderly movement of cells from one site to another in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022029 ! telencephalon cell migration
relationship: part_of GO:0021987 ! cerebral cortex development

[Term]
id: GO:0021796
name: cerebral cortex regionalization
namespace: biological_process
def: "The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "cerebral cortex arealization" EXACT []
synonym: "cerebral cortex pattern biosynthesis" EXACT []
synonym: "cerebral cortex pattern formation" EXACT []
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0021978 ! telencephalon regionalization
relationship: part_of GO:0021987 ! cerebral cortex development

[Term]
id: GO:0021797
name: forebrain anterior/posterior pattern formation
namespace: biological_process
def: "The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "forebrain anterior-posterior pattern formation" EXACT []
is_a: GO:0009952 ! anterior/posterior pattern formation
relationship: part_of GO:0021871 ! forebrain regionalization

[Term]
id: GO:0021798
name: forebrain dorsal/ventral pattern formation
namespace: biological_process
def: "The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "forebrain dorsal-ventral pattern formation" EXACT [GOC:mah]
synonym: "forebrain dorsal-ventral pattern formation" EXACT []
synonym: "forebrain dorsoventral pattern formation" EXACT [GOC:mah]
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0021871 ! forebrain regionalization

[Term]
id: GO:0021799
name: cerebral cortex radially oriented cell migration
namespace: biological_process
def: "The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021795 ! cerebral cortex cell migration

[Term]
id: GO:0021800
name: cerebral cortex tangential migration
namespace: biological_process
def: "The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021795 ! cerebral cortex cell migration

[Term]
id: GO:0021801
name: cerebral cortex radial glia guided migration
namespace: biological_process
def: "The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "glial-guided locomotion" RELATED [PMID:12626695]
is_a: GO:0021799 ! cerebral cortex radially oriented cell migration

[Term]
id: GO:0021802
name: somal translocation
namespace: biological_process
def: "The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "perikaryal translocation of Morest" EXACT [PMID:12626695]
is_a: GO:0021799 ! cerebral cortex radially oriented cell migration

[Term]
id: GO:0021803
name: pial surface process extension
namespace: biological_process
def: "The extension of a long process to the pial surface as a cell leaves the ventricular zone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030031 ! cell projection assembly
relationship: part_of GO:0021802 ! somal translocation

[Term]
id: GO:0021804
name: negative regulation of cell adhesion in the ventricular zone
namespace: biological_process
def: "The process that results in the loss of attachments of a cell in the ventricular zone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "down regulation of cell adhesion in the ventricular zone" EXACT []
synonym: "down-regulation of cell adhesion in the ventricular zone" EXACT []
synonym: "downregulation of cell adhesion in the ventricular zone" EXACT []
synonym: "inhibition of cell adhesion in the ventricular zone" NARROW []
is_a: GO:0007162 ! negative regulation of cell adhesion
relationship: part_of GO:0021802 ! somal translocation

[Term]
id: GO:0021805
name: cell movement involved in somal translocation
namespace: biological_process
def: "The movement of a cell body from the ventricular zone to the pial surface with a concomitant shortening of the process that extends to the pial surface." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0006928 ! cellular component movement
relationship: part_of GO:0021802 ! somal translocation

[Term]
id: GO:0021806
name: initiation of movement involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The initial stages of cell motility involved in the glial-mediated movement of cells in the developing cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "initiation of movement involved in cerebral cortex glial-mediated radial migration" RELATED [GOC:dph]
is_a: GO:0001667 ! ameboidal cell migration
relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021807
name: motogenic signaling initiating cell movement in the cerebral cortex
namespace: biological_process
def: "The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "motogenic signalling initiating cell movement in the cerebral cortex" EXACT []
is_a: GO:0007154 ! cell communication
relationship: part_of GO:0021806 ! initiation of movement involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021808
name: cytosolic calcium signaling involved in the initiation of cell movement in glial-mediated radial cell migration
namespace: biological_process
def: "The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "cytosolic calcium signalling involved in the initiation of cell movement in glial-mediated radial cell migration" EXACT []
is_a: GO:0019722 ! calcium-mediated signaling
relationship: part_of GO:0021806 ! initiation of movement involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021809
name: neurotrophic factor signaling initiating cell movement, involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "neurotrophic factor signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration" EXACT []
is_a: GO:0021807 ! motogenic signaling initiating cell movement in the cerebral cortex

[Term]
id: GO:0021810
name: neurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "neurotransmitter signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration" EXACT []
is_a: GO:0021807 ! motogenic signaling initiating cell movement in the cerebral cortex

[Term]
id: GO:0021811
name: growth factor signaling initiating cell movement involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "growth factor signaling initiating cell movement involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:mtg_cardio]
synonym: "growth factor signalling initiating cell movement involved in cerebral cortex glial-mediated radial migration" EXACT []
is_a: GO:0021807 ! motogenic signaling initiating cell movement in the cerebral cortex

[Term]
id: GO:0021812
name: neuronal-glial interaction involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "neuronal-glial interaction involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration

[Term]
id: GO:0021813
name: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0021812 ! neuronal-glial interaction involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021814
name: cell motility involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
synonym: "cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph]
is_a: GO:0048870 ! cell motility
relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration

[Term]
id: GO:0021815
name: modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "modulation of microtubule cytoskeleton involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
is_a: GO:0000226 ! microtubule cytoskeleton organization
relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021816
name: extension of a leading process involved in cell locomotion in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0031269 ! pseudopodium assembly
relationship: part_of GO:0021815 ! modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021817
name: nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "nucleokinesis involved in cell locomotion in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
synonym: "nucleokinesis involved in cell locomotion in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb]
is_a: GO:0030473 ! nuclear migration along microtubule
relationship: part_of GO:0021815 ! modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021818
name: modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
is_a: GO:0030036 ! actin cytoskeleton organization
relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration

[Term]
id: GO:0021819
name: layer formation in the cerebral cortex
namespace: biological_process
def: "The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "cerebral cortex lamination" RELATED [PMID:12626695]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration

[Term]
id: GO:0021820
name: organization of extracellular matrix in the marginal zone involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The process that leads to the deposition of extracellular matrix signals in the marginal zone of the developing cerebral cortex. This extracellular matrix controls the movement of migrating cells. In mammals, the matrix is modified by Cajal-Retzius cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "organization of extracellular matrix in the marginal zone involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
is_a: GO:0030198 ! extracellular matrix organization
relationship: part_of GO:0021819 ! layer formation in the cerebral cortex

[Term]
id: GO:0021821
name: negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination
namespace: biological_process
def: "The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "down regulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT []
synonym: "down-regulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT []
synonym: "downregulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT []
synonym: "inhibition of cell-glial cell adhesion involved in cerebral cortex lamination" NARROW []
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
relationship: part_of GO:0021819 ! layer formation in the cerebral cortex

[Term]
id: GO:0021822
name: negative regulation of cell motility involved in cerebral cortex radial glia guided migration
namespace: biological_process
def: "The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "down regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT []
synonym: "down-regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT []
synonym: "downregulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT []
synonym: "inhibition of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" NARROW []
synonym: "negative regulation of cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph]
synonym: "negative regulation of cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb]
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0051960 ! regulation of nervous system development
relationship: negatively_regulates GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration
relationship: part_of GO:0021819 ! layer formation in the cerebral cortex

[Term]
id: GO:0021823
name: cerebral cortex tangential migration using cell-cell interactions
namespace: biological_process
def: "The process whereby neurons interact with each other to promote migration along a tangential plane." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "chain migration" RELATED [PMID:12626695]
is_a: GO:0021825 ! substrate-dependent cerebral cortex tangential migration

[Term]
id: GO:0021824
name: cerebral cortex tangential migration using cell-axon interactions
namespace: biological_process
def: "The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021825 ! substrate-dependent cerebral cortex tangential migration

[Term]
id: GO:0021825
name: substrate-dependent cerebral cortex tangential migration
namespace: biological_process
def: "The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0006929 ! substrate-bound cell migration
is_a: GO:0021800 ! cerebral cortex tangential migration

[Term]
id: GO:0021826
name: substrate-independent telencephalic tangential migration
namespace: biological_process
def: "The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022029 ! telencephalon cell migration

[Term]
id: GO:0021827
name: postnatal olfactory bulb interneuron migration
namespace: biological_process
def: "The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions
is_a: GO:0022028 ! tangential migration from the subventricular zone to the olfactory bulb
relationship: part_of GO:0021891 ! olfactory bulb interneuron development

[Term]
id: GO:0021828
name: gonadotrophin-releasing hormone neuronal migration to the hypothalamus
namespace: biological_process
alt_id: GO:0021857
def: "The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021824 ! cerebral cortex tangential migration using cell-axon interactions
is_a: GO:0021856 ! hypothalamic tangential migration using cell-axon interactions
relationship: part_of GO:0021888 ! hypothalamus gonadotrophin-releasing hormone neuron development

[Term]
id: GO:0021829
name: oligodendrocyte cell migration from the subpallium to the cortex
namespace: biological_process
def: "The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021826 ! substrate-independent telencephalic tangential migration

[Term]
id: GO:0021830
name: interneuron migration from the subpallium to the cortex
namespace: biological_process
def: "The directed movement of interneurons from the subpallium to the cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration

[Term]
id: GO:0021831
name: embryonic olfactory bulb interneuron precursor migration
namespace: biological_process
def: "The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration
is_a: GO:0022028 ! tangential migration from the subventricular zone to the olfactory bulb
relationship: part_of GO:0021891 ! olfactory bulb interneuron development

[Term]
id: GO:0021832
name: cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions
namespace: biological_process
def: "The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions

[Term]
id: GO:0021833
name: cell-matrix adhesion involved in tangential migration using cell-cell interactions
namespace: biological_process
def: "The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex." [GO_REF:0000021, GOC:ascb_2009, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0031589 ! cell-substrate adhesion
relationship: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions

[Term]
id: GO:0021834
name: chemorepulsion involved in embryonic olfactory bulb interneuron migration
namespace: biological_process
def: "The creation and reception of signals that guide olfactory bulb interneurons down concentration gradients towards the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "negative chemotaxis involved in embryonic olfactory bulb interneuron migration" EXACT [GOC:mah]
is_a: GO:0050919 ! negative chemotaxis
relationship: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration

[Term]
id: GO:0021835
name: chemoattraction involved in embryonic olfactory bulb interneuron migration
namespace: biological_process
def: "The creation and reception of signals that result in the migration of interneurons up a concentration gradient towards the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "positive chemotaxis involved in embryonic olfactory bulb interneuron migration" EXACT [GOC:mah]
is_a: GO:0050918 ! positive chemotaxis
relationship: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration

[Term]
id: GO:0021836
name: chemorepulsion involved in postnatal olfactory bulb interneuron migration
namespace: biological_process
def: "The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "negative chemotaxis involved in postnatal olfactory bulb interneuron migration" EXACT [GOC:mah]
is_a: GO:0050919 ! negative chemotaxis
relationship: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration

[Term]
id: GO:0021837
name: motogenic signaling involved in postnatal olfactory bulb interneuron migration
namespace: biological_process
def: "The signaling that results in the stimulation of cell movement in the rostral migratory stream." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "motogenic signalling involved in postnatal olfactory bulb interneuron migration" EXACT []
is_a: GO:0007154 ! cell communication
relationship: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration

[Term]
id: GO:0021838
name: motogenic signaling involved in interneuron migration from the subpallium to the cortex
namespace: biological_process
def: "The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "motogenic signalling involved in interneuron migration from the subpallium to the cortex" EXACT []
is_a: GO:0007154 ! cell communication
relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex

[Term]
id: GO:0021839
name: interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex
namespace: biological_process
def: "The process whereby migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0031589 ! cell-substrate adhesion
relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex

[Term]
id: GO:0021840
name: directional guidance of interneurons involved in migration from the subpallium to the cortex
namespace: biological_process
def: "The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030334 ! regulation of cell migration
relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex

[Term]
id: GO:0021841
name: chemoattraction involved in interneuron migration from the subpallium to the cortex
namespace: biological_process
def: "The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "positive chemotaxis involved in interneuron migration from the subpallium to the cortex" EXACT [GOC:mah]
is_a: GO:0050918 ! positive chemotaxis
relationship: part_of GO:0021840 ! directional guidance of interneurons involved in migration from the subpallium to the cortex

[Term]
id: GO:0021842
name: chemorepulsion involved in interneuron migration from the subpallium to the cortex
namespace: biological_process
def: "The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "negative chemotaxis involved in interneuron migration from the subpallium to the cortex" EXACT [GOC:mah]
is_a: GO:0050919 ! negative chemotaxis
relationship: part_of GO:0021840 ! directional guidance of interneurons involved in migration from the subpallium to the cortex

[Term]
id: GO:0021843
name: substrate-independent telencephalic tangential interneuron migration
namespace: biological_process
def: "The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021826 ! substrate-independent telencephalic tangential migration

[Term]
id: GO:0021844
name: interneuron sorting involved in substrate-independent cerebral cortex tangential migration
namespace: biological_process
def: "The establishment and response to guidance cues that distribute interneurons to different cerebral cortex structures." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0042330 ! taxis
relationship: part_of GO:0021843 ! substrate-independent telencephalic tangential interneuron migration

[Term]
id: GO:0021845
name: neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration
namespace: biological_process
def: "The response of migrating interneurons to neurotransmitters that alter electrical activity in cells in calcium dependent manner." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030334 ! regulation of cell migration
relationship: part_of GO:0021843 ! substrate-independent telencephalic tangential interneuron migration

[Term]
id: GO:0021846
name: cell proliferation in forebrain
namespace: biological_process
def: "The creation of greater cell numbers in the forebrain due to cell division of progenitor cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021847
name: neuroblast division in the ventricular zone
namespace: biological_process
def: "The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021869 ! forebrain ventricular zone progenitor cell division
is_a: GO:0021873 ! forebrain neuroblast division

[Term]
id: GO:0021848
name: neuroblast division in the subpallium
namespace: biological_process
def: "The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "neuroblast division in the ventral telencephalon" EXACT [PMID:16226447]
is_a: GO:0021873 ! forebrain neuroblast division
relationship: part_of GO:0022012 ! subpallium cell proliferation in the forebrain

[Term]
id: GO:0021849
name: neuroblast division in the subventricular zone
namespace: biological_process
def: "The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021873 ! forebrain neuroblast division
relationship: part_of GO:0021846 ! cell proliferation in forebrain

[Term]
id: GO:0021850
name: glioblast cell division in the subpallium
namespace: biological_process
def: "The division of glioblasts in the subpallium. These cells will give rise to oligodendrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "glioblast cell division in the ventral telencephalon" EXACT [PMID:16226447]
is_a: GO:0048860 ! glioblast cell division
relationship: part_of GO:0022012 ! subpallium cell proliferation in the forebrain

[Term]
id: GO:0021851
name: neuroblast division in the dorsal lateral ganglionic eminence
namespace: biological_process
def: "The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021848 ! neuroblast division in the subpallium

[Term]
id: GO:0021852
name: pyramidal neuron migration
namespace: biological_process
def: "The migration of pyramidal a neuron precursor from the ventricular zone to the correct layer of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
synonym: "projection neuron migration" RELATED [PMID:12626695]
is_a: GO:0001764 ! neuron migration
is_a: GO:0021801 ! cerebral cortex radial glia guided migration
relationship: part_of GO:0021860 ! pyramidal neuron development

[Term]
id: GO:0021853
name: cerebral cortex GABAergic interneuron migration
namespace: biological_process
def: "The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021830 ! interneuron migration from the subpallium to the cortex
relationship: part_of GO:0021894 ! cerebral cortex GABAergic interneuron development

[Term]
id: GO:0021854
name: hypothalamus development
namespace: biological_process
def: "The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021536 ! diencephalon development
relationship: part_of GO:0021761 ! limbic system development

[Term]
id: GO:0021855
name: hypothalamus cell migration
namespace: biological_process
def: "The directed movement of a cell into the hypothalamus region of the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0021854 ! hypothalamus development

[Term]
id: GO:0021856
name: hypothalamic tangential migration using cell-axon interactions
namespace: biological_process
def: "The movement of a hypothalamic neuronal precursor tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021855 ! hypothalamus cell migration

[Term]
id: GO:0021858
name: GABAergic neuron differentiation in the basal ganglia
namespace: biological_process
def: "The process whereby a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0021859
name: pyramidal neuron differentiation
namespace: biological_process
def: "The process whereby a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "projection neuron differentiation" BROAD [PMID:16226447]
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0021860
name: pyramidal neuron development
namespace: biological_process
def: "The progression of a pyramidal neuron from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "projection neuron development" BROAD [PMID:16226447]
is_a: GO:0021884 ! forebrain neuron development
relationship: part_of GO:0021859 ! pyramidal neuron differentiation

[Term]
id: GO:0021861
name: radial glial cell differentiation in the forebrain
namespace: biological_process
def: "The process whereby neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0060019 ! radial glial cell differentiation
relationship: part_of GO:0021872 ! generation of neurons in the forebrain

[Term]
id: GO:0021862
name: early neuron differentiation in the forebrain
namespace: biological_process
def: "The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021879 ! forebrain neuron differentiation

[Term]
id: GO:0021863
name: forebrain neuroblast differentiation
namespace: biological_process
def: "The process whereby neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
synonym: "abventricular progenitor cell differentiation" EXACT [PMID:16226447]
synonym: "intermediate progenitor cell differentiation" EXACT [PMID:16226447]
synonym: "non-surface dividing progenitor cell differentiation" EXACT [PMID:16226447]
is_a: GO:0014016 ! neuroblast differentiation
relationship: part_of GO:0021872 ! generation of neurons in the forebrain

[Term]
id: GO:0021864
name: radial glial cell division in the forebrain
namespace: biological_process
def: "The mitotic division of radial glial cells in the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0051301 ! cell division
relationship: part_of GO:0021846 ! cell proliferation in forebrain

[Term]
id: GO:0021865
name: symmetric radial glial cell division in the forebrain
namespace: biological_process
def: "The mitotic division of a radial glial cell giving rise to two new radial glial cells in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021864 ! radial glial cell division in the forebrain

[Term]
id: GO:0021866
name: asymmetric radial glial cell division in the forebrain
namespace: biological_process
def: "The mitotic cell division of a radial glial cell giving rise to a radial glial cell and another cell type." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021864 ! radial glial cell division in the forebrain

[Term]
id: GO:0021867
name: neuron-producing asymmetric radial glial cell division in the forebrain
namespace: biological_process
def: "The unequal mitotic division of a radial glial cell in the forebrain that gives rise to a radial glial cell and a post-mitotic neuronal progenitor." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021866 ! asymmetric radial glial cell division in the forebrain

[Term]
id: GO:0021868
name: ventricular zone cell-producing asymmetric radial glial cell division in the forebrain
namespace: biological_process
def: "The unequal mitotic division of a forebrain radial glial cell that gives rise to a radial glial cell and a ventricular zone cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021866 ! asymmetric radial glial cell division in the forebrain

[Term]
id: GO:0021869
name: forebrain ventricular zone progenitor cell division
namespace: biological_process
def: "The mitotic division of a basal progenitor giving rise to two neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0051301 ! cell division
relationship: part_of GO:0021846 ! cell proliferation in forebrain

[Term]
id: GO:0021870
name: Cajal-Retzius cell differentiation
namespace: biological_process
def: "The process whereby a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021895 ! cerebral cortex neuron differentiation

[Term]
id: GO:0021871
name: forebrain regionalization
namespace: biological_process
def: "The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021872
name: generation of neurons in the forebrain
namespace: biological_process
def: "The process by which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048699 ! generation of neurons
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021873
name: forebrain neuroblast division
namespace: biological_process
def: "The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0055057 ! neuroblast division
relationship: part_of GO:0021872 ! generation of neurons in the forebrain

[Term]
id: GO:0021874
name: Wnt receptor signaling pathway in forebrain neuroblast division
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
synonym: "Wnt receptor signalling pathway in forebrain neuroblast division" EXACT []
is_a: GO:0016055 ! Wnt receptor signaling pathway
relationship: part_of GO:0021873 ! forebrain neuroblast division

[Term]
id: GO:0021875
name: fibroblast growth factor receptor signaling pathway involved in forebrain neuroblast division
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
synonym: "fibroblast growth factor receptor signalling pathway in forebrain neuroblast division" EXACT []
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0021873 ! forebrain neuroblast division

[Term]
id: GO:0021876
name: Notch signaling pathway involved in forebrain neuroblast division
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
synonym: "Notch signalling pathway in forebrain neuroblast division" EXACT []
is_a: GO:0007219 ! Notch signaling pathway
relationship: part_of GO:0021873 ! forebrain neuroblast division

[Term]
id: GO:0021877
name: forebrain neuron fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0021879 ! forebrain neuron differentiation

[Term]
id: GO:0021878
name: forebrain astrocyte fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0060018 ! astrocyte fate commitment
relationship: part_of GO:0021896 ! forebrain astrocyte differentiation

[Term]
id: GO:0021879
name: forebrain neuron differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0021872 ! generation of neurons in the forebrain

[Term]
id: GO:0021880
name: Notch signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
synonym: "Notch signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_a: GO:0007219 ! Notch signaling pathway
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain

[Term]
id: GO:0021881
name: Wnt receptor signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
synonym: "Wnt receptor signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_a: GO:0016055 ! Wnt receptor signaling pathway
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain

[Term]
id: GO:0021882
name: regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0010551 ! regulation of gene-specific transcription from RNA polymerase II promoter
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain

[Term]
id: GO:0021883
name: cell cycle arrest of committed forebrain neuronal progenitor cell
namespace: biological_process
def: "The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M) in a cell that has been committed to become a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0007050 ! cell cycle arrest
relationship: part_of GO:0021879 ! forebrain neuron differentiation

[Term]
id: GO:0021884
name: forebrain neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021954 ! central nervous system neuron development
relationship: part_of GO:0021879 ! forebrain neuron differentiation

[Term]
id: GO:0021885
name: forebrain cell migration
namespace: biological_process
def: "The orderly movement of a cell from one site to another at least one of which is located in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021886
name: hypothalamus gonadotrophin-releasing hormone neuron differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021979 ! hypothalamus cell differentiation

[Term]
id: GO:0021887
name: hypothalamus gonadotrophin-releasing hormone neuron fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a hypothalamus neuron that releases gonadotrophin-releasing hormone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0021886 ! hypothalamus gonadotrophin-releasing hormone neuron differentiation

[Term]
id: GO:0021888
name: hypothalamus gonadotrophin-releasing hormone neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a hypothalamus gonadotrophin-releasing hormone neuron over time, from initial commitment of its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021884 ! forebrain neuron development
relationship: part_of GO:0021886 ! hypothalamus gonadotrophin-releasing hormone neuron differentiation

[Term]
id: GO:0021889
name: olfactory bulb interneuron differentiation
namespace: biological_process
def: "The process whereby a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021772 ! olfactory bulb development

[Term]
id: GO:0021890
name: olfactory bulb interneuron fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0021889 ! olfactory bulb interneuron differentiation

[Term]
id: GO:0021891
name: olfactory bulb interneuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0021889 ! olfactory bulb interneuron differentiation

[Term]
id: GO:0021892
name: cerebral cortex GABAergic interneuron differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021895 ! cerebral cortex neuron differentiation

[Term]
id: GO:0021893
name: cerebral cortex GABAergic interneuron fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0021892 ! cerebral cortex GABAergic interneuron differentiation

[Term]
id: GO:0021894
name: cerebral cortex GABAergic interneuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021954 ! central nervous system neuron development
relationship: part_of GO:0021892 ! cerebral cortex GABAergic interneuron differentiation

[Term]
id: GO:0021895
name: cerebral cortex neuron differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021896
name: forebrain astrocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048708 ! astrocyte differentiation
relationship: part_of GO:0030900 ! forebrain development

[Term]
id: GO:0021897
name: forebrain astrocyte development
namespace: biological_process
def: "The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0014002 ! astrocyte development
relationship: part_of GO:0021896 ! forebrain astrocyte differentiation

[Term]
id: GO:0021898
name: commitment of multipotent stem cells to the neuronal lineage in the forebrain
namespace: biological_process
def: "The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12626695]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021877 ! forebrain neuron fate commitment

[Term]
id: GO:0021899
name: fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
synonym: "fibroblast growth factor receptor signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain

[Term]
id: GO:0021900
name: ventricular zone cell fate commitment
namespace: biological_process
def: "The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain
relationship: part_of GO:0021863 ! forebrain neuroblast differentiation

[Term]
id: GO:0021901
name: early neuron fate commitment in the forebrain
namespace: biological_process
def: "The commitment of neuroepithelial cell to become a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain
relationship: part_of GO:0021862 ! early neuron differentiation in the forebrain

[Term]
id: GO:0021902
name: commitment of a neuronal cell to a specific type of neuron in the forebrain
namespace: biological_process
def: "The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:16226447]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021877 ! forebrain neuron fate commitment

[Term]
id: GO:0021903
name: rostrocaudal neural tube patterning
namespace: biological_process
def: "The process by which the neural tube is divided into specific regions along the rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "anterior-posterior neural tube patterning" RELATED [GOC:dph]
is_a: GO:0009952 ! anterior/posterior pattern formation
relationship: part_of GO:0021532 ! neural tube patterning

[Term]
id: GO:0021904
name: dorsal/ventral neural tube patterning
namespace: biological_process
def: "The process by which the neural tube is regionalized in the dorsoventral axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "dorsal-ventral neural tube patterning" EXACT [GOC:dph]
synonym: "dorsoventral neural tube patterning" EXACT [GOC:mah]
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0021532 ! neural tube patterning

[Term]
id: GO:0021905
name: forebrain-midbrain boundary formation
namespace: biological_process
def: "The process whose specific outcome is the creation of the forebrain-midbrain boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning

[Term]
id: GO:0021906
name: hindbrain-spinal cord boundary formation
namespace: biological_process
def: "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning

[Term]
id: GO:0021907
name: fibroblast growth factor receptor signaling pathway involved in spinal cord anterior/posterior pattern formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "fibroblast growth factor receptor signalling pathway in spinal cord anterior-posterior patterning" EXACT []
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning

[Term]
id: GO:0021908
name: retinoic acid receptor signaling pathway involved in spinal cord anterior/posterior pattern formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "retinoic acid receptor signalling pathway in spinal cord anterior-posterior patterning" EXACT []
is_a: GO:0048384 ! retinoic acid receptor signaling pathway
relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning

[Term]
id: GO:0021909
name: regulation of transcription from RNA polymerase II promoter involved in spinal cord anterior-posterior patterning
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0010551 ! regulation of gene-specific transcription from RNA polymerase II promoter
relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning

[Term]
id: GO:0021910
name: smoothened signaling pathway involved in ventral spinal cord patterning
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "smoothened signalling pathway in ventral spinal cord patterning" EXACT []
is_a: GO:0007224 ! smoothened signaling pathway
relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning

[Term]
id: GO:0021911
name: retinoic acid metabolic process in spinal cord anterior-posterior patterning
namespace: biological_process
def: "The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "retinoic acid metabolism in spinal cord anterior-posterior patterning" EXACT []
is_a: GO:0042573 ! retinoic acid metabolic process
relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning

[Term]
id: GO:0021912
name: regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0010551 ! regulation of gene-specific transcription from RNA polymerase II promoter
relationship: part_of GO:0021520 ! spinal cord motor neuron cell fate specification

[Term]
id: GO:0021913
name: regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0010551 ! regulation of gene-specific transcription from RNA polymerase II promoter
relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification

[Term]
id: GO:0021914
name: negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "down regulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT []
synonym: "down-regulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT []
synonym: "downregulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT []
synonym: "inhibition of smoothened signaling pathway in ventral spinal cord patterning" NARROW []
synonym: "negative regulation of smoothened signalling pathway in ventral spinal cord patterning" EXACT []
is_a: GO:0045879 ! negative regulation of smoothened signaling pathway
is_a: GO:0051960 ! regulation of nervous system development
relationship: negatively_regulates GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning
relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning

[Term]
id: GO:0021915
name: neural tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007399 ! nervous system development
relationship: part_of GO:0043009 ! chordate embryonic development

[Term]
id: GO:0021916
name: inductive cell-cell signaling between paraxial mesoderm and motor neuron precursors
namespace: biological_process
def: "Short range signaling between cells of the paraxial mesoderm and motor neuron precursors in the spinal cord that specifies the fate of the motor column neuron precursors along the anterior-posterior axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
synonym: "inductive cell-cell signalling between paraxial mesoderm and motor neuron precursors" EXACT []
is_a: GO:0031129 ! inductive cell-cell signaling
relationship: part_of GO:0021917 ! somatic motor neuron fate commitment

[Term]
id: GO:0021917
name: somatic motor neuron fate commitment
namespace: biological_process
def: "The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0021523 ! somatic motor neuron differentiation

[Term]
id: GO:0021918
name: regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of spinal cord motor neurons to specific motor neuron types along the anterior-posterior axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11262869]
comment: This term was added by GO_REF:0000021.
is_a: GO:0010551 ! regulation of gene-specific transcription from RNA polymerase II promoter
relationship: part_of GO:0021917 ! somatic motor neuron fate commitment

[Term]
id: GO:0021919
name: BMP signaling pathway in spinal cord dorsal/ventral patterning
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12593981]
comment: This term was added by GO_REF:0000021.
synonym: "BMP signaling pathway in spinal cord dorsal-ventral patterning" EXACT [GOC:mah]
synonym: "BMP signaling pathway in spinal cord dorsoventral patterning" EXACT [GOC:mah]
synonym: "BMP signalling pathway in spinal cord dorsal-ventral patterning" EXACT []
synonym: "bone morphogenetic protein signaling pathway in spinal cord dorsal-ventral patterning" EXACT []
synonym: "bone morphogenetic protein signalling pathway in spinal cord dorsal-ventral patterning" EXACT []
is_a: GO:0030509 ! BMP signaling pathway
relationship: part_of GO:0021914 ! negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning

[Term]
id: GO:0021920
name: regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of neuronal precursors to association neurons in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12593981]
comment: This term was added by GO_REF:0000021.
is_a: GO:0010551 ! regulation of gene-specific transcription from RNA polymerase II promoter
relationship: part_of GO:0021519 ! spinal cord association neuron specification

[Term]
id: GO:0021921
name: regulation of cell proliferation in dorsal spinal cord
namespace: biological_process
def: "The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0042127 ! regulation of cell proliferation
relationship: part_of GO:0021516 ! dorsal spinal cord development
relationship: regulates GO:0010456 ! cell proliferation in dorsal spinal cord

[Term]
id: GO:0021922
name: Wnt receptor signaling pathway involved in regulation of cell proliferation in dorsal spinal cord
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of a cell in the dorsal spinal cord that affects the rate of its division." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12593981]
comment: This term was added by GO_REF:0000021.
synonym: "Wnt receptor signalling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT []
is_a: GO:0016055 ! Wnt receptor signaling pathway
relationship: part_of GO:0021921 ! regulation of cell proliferation in dorsal spinal cord

[Term]
id: GO:0021923
name: cell proliferation in the hindbrain ventricular zone
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12593981, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021534 ! cell proliferation in hindbrain

[Term]
id: GO:0021924
name: cell proliferation in the external granule layer
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021534 ! cell proliferation in hindbrain

[Term]
id: GO:0021925
name: cerebellar Purkinje cell precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021923 ! cell proliferation in the hindbrain ventricular zone

[Term]
id: GO:0021926
name: Golgi cell precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021923 ! cell proliferation in the hindbrain ventricular zone

[Term]
id: GO:0021927
name: deep nuclear neuron precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to deep nuclear neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021923 ! cell proliferation in the hindbrain ventricular zone

[Term]
id: GO:0021928
name: basket cell precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021923 ! cell proliferation in the hindbrain ventricular zone

[Term]
id: GO:0021929
name: stellate cell precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021923 ! cell proliferation in the hindbrain ventricular zone

[Term]
id: GO:0021930
name: granule cell precursor proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021924 ! cell proliferation in the external granule layer

[Term]
id: GO:0021931
name: rostral hindbrain neuronal precursor cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021924 ! cell proliferation in the external granule layer

[Term]
id: GO:0021932
name: hindbrain radial glia guided cell migration
namespace: biological_process
def: "The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021535 ! cell migration in hindbrain

[Term]
id: GO:0021933
name: radial glia guided migration of granule cell
namespace: biological_process
def: "The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021932 ! hindbrain radial glia guided cell migration

[Term]
id: GO:0021934
name: hindbrain tangential cell migration
namespace: biological_process
def: "The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "hindbrain neurophilic migration" RELATED [PMID:15157725]
is_a: GO:0021535 ! cell migration in hindbrain

[Term]
id: GO:0021935
name: granule cell precursor tangential migration
namespace: biological_process
def: "The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021934 ! hindbrain tangential cell migration

[Term]
id: GO:0021936
name: regulation of granule cell precursor proliferation
namespace: biological_process
def: "The process that modulates the frequency, rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0051960 ! regulation of nervous system development
relationship: regulates GO:0021930 ! granule cell precursor proliferation

[Term]
id: GO:0021937
name: cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
namespace: biological_process
def: "The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "Purkinje cell-granule cell precursor cell signalling involved in regulation of granule cell precursor cell proliferation" EXACT []
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0021940 ! positive regulation of granule cell precursor proliferation

[Term]
id: GO:0021938
name: smoothened signaling pathway involved in regulation of granule cell precursor cell proliferation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in granule cells that contributes to the regulation of proliferation of the cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "smoothened signalling pathway in regulation of granule cell precursor cell proliferation" EXACT []
is_a: GO:0007224 ! smoothened signaling pathway
relationship: part_of GO:0021937 ! cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation

[Term]
id: GO:0021939
name: extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation
namespace: biological_process
def: "The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "extracellular matrix-granule cell signalling involved in regulation of granule cell precursor proliferation" EXACT []
is_a: GO:0007154 ! cell communication
relationship: part_of GO:0021941 ! negative regulation of granule cell precursor proliferation

[Term]
id: GO:0021940
name: positive regulation of granule cell precursor proliferation
namespace: biological_process
def: "The process that activates or increases the rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "activation of granule cell precursor proliferation" NARROW []
synonym: "stimulation of granule cell precursor proliferation" NARROW []
synonym: "up regulation of granule cell precursor proliferation" EXACT []
synonym: "up-regulation of granule cell precursor proliferation" EXACT []
synonym: "upregulation of granule cell precursor proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0021936 ! regulation of granule cell precursor proliferation
relationship: positively_regulates GO:0021930 ! granule cell precursor proliferation

[Term]
id: GO:0021941
name: negative regulation of granule cell precursor proliferation
namespace: biological_process
def: "The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "down regulation of granule cell precursor proliferation" EXACT []
synonym: "down-regulation of granule cell precursor proliferation" EXACT []
synonym: "downregulation of granule cell precursor proliferation" EXACT []
synonym: "inhibition of granule cell precursor proliferation" NARROW []
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0021936 ! regulation of granule cell precursor proliferation
relationship: negatively_regulates GO:0021930 ! granule cell precursor proliferation

[Term]
id: GO:0021942
name: radial glia guided migration of Purkinje cell
namespace: biological_process
def: "The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021932 ! hindbrain radial glia guided cell migration

[Term]
id: GO:0021943
name: formation of radial glial scaffolds
namespace: biological_process
def: "The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "Bergmann fiber biosynthesis" RELATED [PMID:15157725]
synonym: "Bergmann fiber formation" RELATED [PMID:15157725]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0021932 ! hindbrain radial glia guided cell migration

[Term]
id: GO:0021944
name: neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration
namespace: biological_process
def: "The changes in adhesion between a neuronal cell and a glial cell as a component of the process of hindbrain glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0021932 ! hindbrain radial glia guided cell migration

[Term]
id: GO:0021945
name: positive regulation of granule cell migration by calcium
namespace: biological_process
def: "The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "calcium-mediated activation of granule cell migration" NARROW []
synonym: "calcium-mediated positive regulation of granule cell migration" EXACT [GOC:dph, GOC:tb]
synonym: "calcium-mediated stimulation of granule cell migration" NARROW []
synonym: "calcium-mediated up regulation of granule cell migration" EXACT []
synonym: "calcium-mediated up-regulation of granule cell migration" EXACT []
synonym: "calcium-mediated upregulation of granule cell migration" EXACT []
is_a: GO:0019722 ! calcium-mediated signaling
is_a: GO:0030335 ! positive regulation of cell migration
relationship: part_of GO:0021933 ! radial glia guided migration of granule cell

[Term]
id: GO:0021946
name: deep nuclear neuron cell migration
namespace: biological_process
def: "The directed movement of a deep nuclear neuron from the ventricular zone to the deep hindbrain nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021535 ! cell migration in hindbrain

[Term]
id: GO:0021947
name: outward migration of deep nuclear neurons
namespace: biological_process
def: "The directed movement of a deep nuclear neuron from their ventrolateral origin to a rostrodorsal region of the cerebellar plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0001764 ! neuron migration
relationship: part_of GO:0021946 ! deep nuclear neuron cell migration

[Term]
id: GO:0021948
name: inward migration of deep nuclear neurons
namespace: biological_process
def: "The directed movement of a deep nuclear neuron from the rostrodorsal region of the cerebellar plate to their final more ventral position." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0001764 ! neuron migration
relationship: part_of GO:0021946 ! deep nuclear neuron cell migration

[Term]
id: GO:0021949
name: brainstem precerebellar neuron precursor migration
namespace: biological_process
def: "The early migration of a precerebellar neuronal precursor in which a cell move from the rhombic lip, orthogonal to the direction of radial migration and ultimately reside in the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021934 ! hindbrain tangential cell migration

[Term]
id: GO:0021950
name: chemorepulsion involved in precerebellar neuron migration
namespace: biological_process
def: "The creation and reception of signals that repel a precerebellar neuron as a component of the process of tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "negative chemotaxis involved in precerebellar neuron migration" EXACT [GOC:mah]
is_a: GO:0050919 ! negative chemotaxis
relationship: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration

[Term]
id: GO:0021951
name: chemoattraction involved in precerebellar neuron migration
namespace: biological_process
def: "The creation and reception of signals that guide a precerebellar neuron towards their signals, where this process is involved in tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15157725]
comment: This term was added by GO_REF:0000021.
synonym: "positive chemotaxis involved in precerebellar neuron migration" EXACT [GOC:mah]
is_a: GO:0050918 ! positive chemotaxis
relationship: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration

[Term]
id: GO:0021952
name: central nervous system projection neuron axonogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "central nervous system axon tract development" NARROW [GOC:dph]
is_a: GO:0021955 ! central nervous system neuron axonogenesis

[Term]
id: GO:0021953
name: central nervous system neuron differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0021954
name: central nervous system neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0021953 ! central nervous system neuron differentiation

[Term]
id: GO:0021955
name: central nervous system neuron axonogenesis
namespace: biological_process
def: "Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0007409 ! axonogenesis
relationship: part_of GO:0021954 ! central nervous system neuron development

[Term]
id: GO:0021956
name: central nervous system interneuron axonogenesis
namespace: biological_process
def: "Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021955 ! central nervous system neuron axonogenesis

[Term]
id: GO:0021957
name: corticospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
synonym: "corticospinal tract axonogenesis" EXACT [GOC:dph, PMID:9878731]
synonym: "CST axonogenesis" EXACT [GOC:dph, PMID:9878731]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021958
name: gracilis tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12867698]
comment: This term was added by GO_REF:0000021.
synonym: "tract of Goll morphogenesis" EXACT [PMID:12867698]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021959
name: cuneatus tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:12867698]
comment: This term was added by GO_REF:0000021.
synonym: "tract of Burdach morphogenesis" EXACT [PMID:12867698]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021960
name: anterior commissure morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0021961
name: posterior commissure morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021962
name: vestibulospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021963
name: spinothalamic tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "dorsolateral tract of Lissauer morphogenesis" EXACT []
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021964
name: rubrospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021965
name: spinal cord ventral commissure morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the spinal cord ventral commissure are generated and organized. Morphogenesis pertains to the creation of form." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021966
name: corticospinal neuron axon guidance
namespace: biological_process
def: "The process by which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
synonym: "corticospinal neuron axon pathfinding" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021957 ! corticospinal tract morphogenesis

[Term]
id: GO:0021967
name: corticospinal neuron axon guidance through the cerebral cortex
namespace: biological_process
def: "The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
synonym: "corticospinal neuron axon pathfinding through the cerebral cortex" NARROW [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021968
name: corticospinal neuron axon guidance through the internal capsule
namespace: biological_process
def: "The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
synonym: "corticospinal neuron axon pathfinding through the internal capsule" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021969
name: corticospinal neuron axon guidance through the cerebral peduncle
namespace: biological_process
def: "The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
synonym: "corticospinal neuron axon pathfinding through the cerebral peduncle" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021970
name: corticospinal neuron axon guidance through the basilar pons
namespace: biological_process
def: "The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
synonym: "corticospinal neuron axon pathfinding through the basilar pons" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021971
name: corticospinal neuron axon guidance through the medullary pyramid
namespace: biological_process
def: "The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
synonym: "corticospinal neuron axon pathfinding through the medullary pyramid" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021972
name: corticospinal neuron axon guidance through the spinal cord
namespace: biological_process
def: "The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
synonym: "corticospinal neuron axon pathfinding through the spinal cord" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021973
name: corticospinal neuron axon decussation
namespace: biological_process
def: "The process by which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:9878731]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016199 ! axon midline choice point recognition
relationship: part_of GO:0021966 ! corticospinal neuron axon guidance

[Term]
id: GO:0021974
name: trigeminothalamic tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the trigeminothalamic tract, one of the major routes of nociceptive and temperature signaling from the face." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878937420]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021975
name: pons reticulospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021976
name: medulla reticulospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021977
name: tectospinal tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0021978
name: telencephalon regionalization
namespace: biological_process
def: "The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mgi_curators, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0021537 ! telencephalon development
relationship: part_of GO:0021871 ! forebrain regionalization

[Term]
id: GO:0021979
name: hypothalamus cell differentiation
namespace: biological_process
def: "The differentiation of cells that will contribute to the structure and function of the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mgi_curators, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021854 ! hypothalamus development

[Term]
id: GO:0021980
name: subpallium cell migration
namespace: biological_process
def: "The orderly movement of cells from one site to another in the subpallium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022029 ! telencephalon cell migration
relationship: part_of GO:0021544 ! subpallium development

[Term]
id: GO:0021981
name: subpallium radially oriented migration
namespace: biological_process
def: "The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021980 ! subpallium cell migration

[Term]
id: GO:0021982
name: pineal gland development
namespace: biological_process
def: "The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "epiphysis development" EXACT [GOC:dph]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0021536 ! diencephalon development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0021983
name: pituitary gland development
namespace: biological_process
def: "The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "hypophysis development" RELATED [GOC:dph]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0021536 ! diencephalon development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0021984
name: adenohypophysis development
namespace: biological_process
def: "The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "adenophysis development" EXACT []
synonym: "anterior pituitary development" EXACT []
synonym: "anterior pituitary gland development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021983 ! pituitary gland development

[Term]
id: GO:0021985
name: neurohypophysis development
namespace: biological_process
def: "The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "neurophysis development" EXACT []
synonym: "posterior pituitary development" EXACT []
synonym: "posterior pituitary gland development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021983 ! pituitary gland development

[Term]
id: GO:0021986
name: habenula development
namespace: biological_process
def: "The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:9780721601465]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021538 ! epithalamus development

[Term]
id: GO:0021987
name: cerebral cortex development
namespace: biological_process
def: "The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "neocortex development" RELATED [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021543 ! pallium development

[Term]
id: GO:0021988
name: olfactory lobe development
namespace: biological_process
def: "The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0021989
name: olfactory cortex development
namespace: biological_process
def: "The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021988 ! olfactory lobe development

[Term]
id: GO:0021990
name: neural plate formation
namespace: biological_process
def: "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0878932437, ISBN:0878932585, PMID:15806586]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0001839 ! neural plate morphogenesis

[Term]
id: GO:0021991
name: neural plate thickening
namespace: biological_process
def: "The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15806586]
comment: This term was added by GO_REF:0000021.
is_a: GO:0002011 ! morphogenesis of an epithelial sheet
relationship: part_of GO:0001839 ! neural plate morphogenesis

[Term]
id: GO:0021992
name: cell proliferation involved in neural plate elongation
namespace: biological_process
def: "The process of expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15806586]
comment: This term was added by GO_REF:0000021.
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0014022 ! neural plate elongation

[Term]
id: GO:0021993
name: initiation of neural tube closure
namespace: biological_process
def: "The process by which closure points are established at multiple points and along the neural rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0001843 ! neural tube closure

[Term]
id: GO:0021994
name: progression of neural tube closure
namespace: biological_process
def: "The process whereby the neural folds are fused extending from the initial closure points." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0001843 ! neural tube closure

[Term]
id: GO:0021995
name: neuropore closure
namespace: biological_process
def: "The process of joining together the neural folds at either end of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0001843 ! neural tube closure

[Term]
id: GO:0021996
name: lamina terminalis formation
namespace: biological_process
def: "The process whereby the anterior-most portion of the neural axis is formed by closure of the anterior neuropore." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0021506 ! anterior neuropore closure

[Term]
id: GO:0021997
name: neural plate axis specification
namespace: biological_process
def: "The pattern specification process whereby the axes of the nervous system are established." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "neural plate axis determination" RELATED [GOC:dph]
is_a: GO:0000578 ! embryonic axis specification
relationship: part_of GO:0001840 ! neural plate development
relationship: part_of GO:0060896 ! neural plate pattern specification

[Term]
id: GO:0021998
name: neural plate mediolateral regionalization
namespace: biological_process
def: "The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "neural plate mediolateral pattern formation" RELATED [GOC:dph]
is_a: GO:0060897 ! neural plate regionalization

[Term]
id: GO:0021999
name: neural plate anterior/posterior regionalization
namespace: biological_process
def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "neural plate anterior/posterior pattern formation" RELATED [GOC:dph]
is_a: GO:0060897 ! neural plate regionalization

[Term]
id: GO:0022000
name: forebrain induction by the anterior neural ridge
namespace: biological_process
def: "The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0031128 ! developmental induction
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization

[Term]
id: GO:0022001
name: negative regulation of anterior neural cell fate commitment of the neural plate
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb]
comment: This term was added by GO_REF:0000021.
synonym: "caudalization of neural plate" EXACT []
synonym: "down regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "down-regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "downregulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "inhibition of anterior neural cell fate of the neural plate" NARROW []
synonym: "negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb]
synonym: "posteriorization" BROAD []
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0051961 ! negative regulation of nervous system development
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization

[Term]
id: GO:0022002
name: Wnt receptor signaling pathway involved in negative regulation of anterior neural cell fate commitment of the neural plate
namespace: biological_process
def: "The series of molecular signals that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb]
comment: This term was added by GO_REF:0000021.
synonym: "Wnt receptor signaling involved in down regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "Wnt receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "Wnt receptor signaling involved in downregulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "Wnt receptor signaling involved in inhibition of anterior neural cell fate of the neural plate" NARROW []
synonym: "Wnt receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb]
synonym: "Wnt receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT []
is_a: GO:0016055 ! Wnt receptor signaling pathway
is_a: GO:0022001 ! negative regulation of anterior neural cell fate commitment of the neural plate

[Term]
id: GO:0022003
name: fibroblast growth factor receptor signaling pathway involved in negative regulation of anterior neural cell fate commitment of the neural plate
namespace: biological_process
def: "The series of molecular signals that stops, prevents or reduces the frequency or rate at which cell adopts an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, GOC:tb]
comment: This term was added by GO_REF:0000021.
synonym: "fgf receptor signaling involved in down regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "fgf receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "fgf receptor signaling involved in downregulation of anterior neural cell fate of the neural plate" EXACT []
synonym: "fgf receptor signaling involved in inhibition of anterior neural cell fate of the neural plate" NARROW []
synonym: "fgf receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb]
synonym: "fgf receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT []
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
is_a: GO:0022001 ! negative regulation of anterior neural cell fate commitment of the neural plate

[Term]
id: GO:0022004
name: midbrain-hindbrain boundary maturation during brain development
namespace: biological_process
def: "A developmental process occurring during brain development, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15541513]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0007420 ! brain development
relationship: part_of GO:0021732 ! midbrain-hindbrain boundary maturation

[Term]
id: GO:0022005
name: midbrain-hindbrain boundary maturation during neural plate development
namespace: biological_process
def: "A developmental process involved in neural plate development. This process is independent of morphogenetic (shape) change, and is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15541513]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0001840 ! neural plate development
relationship: part_of GO:0021732 ! midbrain-hindbrain boundary maturation

[Term]
id: GO:0022006
name: zona limitans intrathalamica formation
namespace: biological_process
def: "The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:11425897, PMID:16452095]
comment: This term was added by GO_REF:0000021.
synonym: "zli biosynthesis" EXACT []
synonym: "zli formation" EXACT []
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning

[Term]
id: GO:0022007
name: convergent extension involved in neural plate elongation
namespace: biological_process
def: "The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:13679871, PMID:15806586]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016477 ! cell migration
is_a: GO:0060026 ! convergent extension
relationship: part_of GO:0014022 ! neural plate elongation

[Term]
id: GO:0022008
name: neurogenesis
namespace: biological_process
def: "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "nervous system cell generation" EXACT systematic_synonym []
synonym: "neural cell differentiation" RELATED [GOC:BHF, GOC:dph]
xref: Wikipedia:Neurogenesis
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0022009
name: central nervous system vasculogenesis
namespace: biological_process
def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0001570 ! vasculogenesis
relationship: part_of GO:0014045 ! establishment of endothelial blood-brain barrier

[Term]
id: GO:0022010
name: myelination in the central nervous system
namespace: biological_process
def: "The process whereby neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "central nervous system myelination" EXACT []
is_a: GO:0032291 ! ensheathment of axons in the central nervous system
is_a: GO:0042552 ! myelination
relationship: part_of GO:0014003 ! oligodendrocyte development

[Term]
id: GO:0022011
name: myelination in the peripheral nervous system
namespace: biological_process
def: "The process whereby neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "peripheral nervous system myelination" EXACT []
is_a: GO:0032292 ! ensheathment of axons in the peripheral nervous system
is_a: GO:0042552 ! myelination
relationship: part_of GO:0014044 ! Schwann cell development

[Term]
id: GO:0022012
name: subpallium cell proliferation in the forebrain
namespace: biological_process
def: "The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021846 ! cell proliferation in forebrain
relationship: part_of GO:0021544 ! subpallium development

[Term]
id: GO:0022013
name: pallium cell proliferation in the forebrain
namespace: biological_process
def: "The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021846 ! cell proliferation in forebrain
relationship: part_of GO:0021543 ! pallium development

[Term]
id: GO:0022014
name: radial glial cell division in the subpallium
namespace: biological_process
def: "The division of a radial glial cell in the subpallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021864 ! radial glial cell division in the forebrain
relationship: part_of GO:0022012 ! subpallium cell proliferation in the forebrain

[Term]
id: GO:0022015
name: radial glial cell division in the pallium
namespace: biological_process
def: "The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0051301 ! cell division
relationship: part_of GO:0022013 ! pallium cell proliferation in the forebrain

[Term]
id: GO:0022016
name: glioblast cell division in the pallium
namespace: biological_process
def: "The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048860 ! glioblast cell division
relationship: part_of GO:0022013 ! pallium cell proliferation in the forebrain

[Term]
id: GO:0022017
name: neuroblast division in the pallium
namespace: biological_process
def: "The division of neuroblast in the pallium. Neuroblasts are precursor cells that give rise to neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021873 ! forebrain neuroblast division
relationship: part_of GO:0022013 ! pallium cell proliferation in the forebrain

[Term]
id: GO:0022018
name: lateral ganglionic eminence cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022012 ! subpallium cell proliferation in the forebrain

[Term]
id: GO:0022019
name: dorsal lateral ganglionic eminence cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022012 ! subpallium cell proliferation in the forebrain
relationship: part_of GO:0022018 ! lateral ganglionic eminence cell proliferation

[Term]
id: GO:0022020
name: medial ganglionic eminence cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of medial ganglionic eminence cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022012 ! subpallium cell proliferation in the forebrain

[Term]
id: GO:0022021
name: caudal ganglionic eminence cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022012 ! subpallium cell proliferation in the forebrain

[Term]
id: GO:0022022
name: septal cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of septal cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "septum cell proliferation" EXACT []
is_a: GO:0022012 ! subpallium cell proliferation in the forebrain

[Term]
id: GO:0022023
name: radial glial cell fate commitment in the forebrain
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain
relationship: part_of GO:0021861 ! radial glial cell differentiation in the forebrain

[Term]
id: GO:0022024
name: BMP signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "BMP signalling pathway involved in forebrain neuron fate commitment" EXACT []
synonym: "bone morphogenetic protein signaling pathway involved in forebrain neuron fate commitment" EXACT []
synonym: "bone morphogenetic protein signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_a: GO:0030509 ! BMP signaling pathway
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain

[Term]
id: GO:0022025
name: leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "leukemia inhibitory factor signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_a: GO:0048861 ! leukemia inhibitory factor signaling pathway
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain

[Term]
id: GO:0022026
name: epidermal growth factor signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "epidermal growth factor signalling pathway involved in forebrain neuron fate commitment" EXACT []
is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway
relationship: part_of GO:0021898 ! commitment of multipotent stem cells to the neuronal lineage in the forebrain

[Term]
id: GO:0022027
name: interkinetic nuclear migration
namespace: biological_process
def: "The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0051647 ! nucleus localization
relationship: part_of GO:0021846 ! cell proliferation in forebrain

[Term]
id: GO:0022028
name: tangential migration from the subventricular zone to the olfactory bulb
namespace: biological_process
def: "The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "rostral migratory stream migration" EXACT []
is_a: GO:0022029 ! telencephalon cell migration
relationship: part_of GO:0021772 ! olfactory bulb development

[Term]
id: GO:0022029
name: telencephalon cell migration
namespace: biological_process
def: "The orderly movement of a cell from one site to another at least one of which is located in the telencephalon." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021885 ! forebrain cell migration
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0022030
name: telencephalon glial cell migration
namespace: biological_process
def: "The orderly movement of glial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0008347 ! glial cell migration
is_a: GO:0022029 ! telencephalon cell migration

[Term]
id: GO:0022031
name: telencephalon astrocyte cell migration
namespace: biological_process
def: "The orderly movement of an astrocyte cell through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022030 ! telencephalon glial cell migration
is_a: GO:0043615 ! astrocyte cell migration

[Term]
id: GO:0022032
name: telencephalon oligodendrocyte cell migration
namespace: biological_process
def: "The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022030 ! telencephalon glial cell migration

[Term]
id: GO:0022033
name: telencephalon microglial cell migration
namespace: biological_process
def: "The orderly movement of microglial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0022030 ! telencephalon glial cell migration

[Term]
id: GO:0022034
name: rhombomere cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of rhombomere cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0021546 ! rhombomere development

[Term]
id: GO:0022035
name: rhombomere cell migration
namespace: biological_process
def: "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, PMID:15629700]
comment: This term was added by GO_REF:0000021.
is_a: GO:0021535 ! cell migration in hindbrain
relationship: part_of GO:0021546 ! rhombomere development

[Term]
id: GO:0022036
name: rhombomere cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a rhombomere cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021546 ! rhombomere development

[Term]
id: GO:0022037
name: metencephalon development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030902 ! hindbrain development

[Term]
id: GO:0022038
name: corpus callosum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021537 ! telencephalon development

[Term]
id: GO:0022400
name: regulation of rhodopsin mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling." [GOC:mah]
synonym: "regulation of rhodopsin mediated signalling" EXACT []
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
relationship: part_of GO:0016056 ! rhodopsin mediated signaling pathway

[Term]
id: GO:0022401
name: negative adaptation of signaling pathway
namespace: biological_process
def: "The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:isa_complete]
synonym: "negative adaptation of signal transduction pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0023058 ! adaptation of signaling pathway

[Term]
id: GO:0022402
name: cell cycle process
namespace: biological_process
def: "A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:isa_complete]
subset: gosubset_prok
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0007049 ! cell cycle

[Term]
id: GO:0022403
name: cell cycle phase
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events." [GOC:isa_complete]
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0022404
name: molting cycle process
namespace: biological_process
def: "A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin." [GOC:isa_complete]
is_a: GO:0042303 ! molting cycle

[Term]
id: GO:0022405
name: hair cycle process
namespace: biological_process
def: "A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:isa_complete]
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0042633 ! hair cycle

[Term]
id: GO:0022406
name: membrane docking
namespace: biological_process
def: "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete]
subset: goslim_pir
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0022407
name: regulation of cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete]
is_a: GO:0030155 ! regulation of cell adhesion
relationship: regulates GO:0016337 ! cell-cell adhesion

[Term]
id: GO:0022408
name: negative regulation of cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete]
synonym: "down regulation of cell-cell adhesion" EXACT []
synonym: "down-regulation of cell-cell adhesion" EXACT []
synonym: "downregulation of cell-cell adhesion" EXACT []
synonym: "inhibition of cell-cell adhesion" NARROW []
is_a: GO:0007162 ! negative regulation of cell adhesion
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: negatively_regulates GO:0016337 ! cell-cell adhesion

[Term]
id: GO:0022409
name: positive regulation of cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]
synonym: "activation of cell-cell adhesion" NARROW []
synonym: "stimulation of cell-cell adhesion" NARROW []
synonym: "up regulation of cell-cell adhesion" EXACT []
synonym: "up-regulation of cell-cell adhesion" EXACT []
synonym: "upregulation of cell-cell adhesion" EXACT []
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:0045785 ! positive regulation of cell adhesion
relationship: positively_regulates GO:0016337 ! cell-cell adhesion

[Term]
id: GO:0022410
name: circadian sleep/wake cycle process
namespace: biological_process
def: "A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:isa_complete]
is_a: GO:0048512 ! circadian behavior
relationship: part_of GO:0042745 ! circadian sleep/wake cycle

[Term]
id: GO:0022411
name: cellular component disassembly
namespace: biological_process
def: "A cellular process that results in the breakdown of a part of the cell." [GOC:isa_complete]
subset: goslim_pir
subset: gosubset_prok
synonym: "cell structure disassembly" EXACT []
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0022412
name: reproductive cellular process in multicellular organism
namespace: biological_process
def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." [GOC:isa_complete]
is_a: GO:0048610 ! reproductive cellular process

[Term]
id: GO:0022413
name: reproductive process in single-celled organism
namespace: biological_process
def: "A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism." [GOC:isa_complete]
subset: gosubset_prok
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0032505 ! reproduction of a single-celled organism

[Term]
id: GO:0022414
name: reproductive process
namespace: biological_process
def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete]
subset: gosubset_prok
is_a: GO:0008150 ! biological_process
relationship: part_of GO:0000003 ! reproduction

[Term]
id: GO:0022415
name: viral reproductive process
namespace: biological_process
def: "A reproductive process involved in viral reproduction. Usually, this is by infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:isa_complete]
synonym: "viral life cycle process" EXACT []
is_a: GO:0022414 ! reproductive process
relationship: part_of GO:0016032 ! viral reproduction

[Term]
id: GO:0022416
name: bristle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bristle over time, from its formation to the mature structure. A bristle is an insect sensory organ." [GOC:isa_complete]
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0022417
name: protein maturation by protein folding
namespace: biological_process
def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein." [GOC:isa_complete]
is_a: GO:0006457 ! protein folding
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0022600
name: digestive system process
namespace: biological_process
def: "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jic, GOC:mtg_cardio]
is_a: GO:0003008 ! system process
relationship: part_of GO:0007586 ! digestion

[Term]
id: GO:0022601
name: menstrual cycle phase
namespace: biological_process
def: "The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur." [GOC:dph, GOC:isa_complete, GOC:jic]
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0048731 ! system development

[Term]
id: GO:0022602
name: ovulation cycle process
namespace: biological_process
def: "A process involved in the sexual cycle seen in female mammals, with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [GOC:isa_complete]
synonym: "estrous cycle process" RELATED []
synonym: "menstrual cycle process" RELATED []
is_a: GO:0048511 ! rhythmic process
relationship: part_of GO:0042698 ! ovulation cycle

[Term]
id: GO:0022603
name: regulation of anatomical structure morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of morphogenesis" EXACT []
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0022604
name: regulation of cell morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process by which the shape of a cell is generated and organized." [GOC:isa_complete]
subset: gosubset_prok
synonym: "negative regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0000902 ! cell morphogenesis

[Term]
id: GO:0022605
name: oogenesis stage
namespace: biological_process
def: "A process that contributes to the formation and maturation of an ovum or female gamete from a primordial female germ cell." [GOC:isa_complete, GOC:mtg_sensu]
synonym: "oogenesis process" EXACT []
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0022606
name: establishment of proximal/distal cell polarity
namespace: biological_process
def: "The specification and formation of the polarity of a cell along its proximal/distal axis." [GOC:isa_complete]
is_a: GO:0030010 ! establishment of cell polarity

[Term]
id: GO:0022607
name: cellular component assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete]
subset: goslim_pir
subset: gosubset_prok
synonym: "cell structure assembly" EXACT []
is_a: GO:0016043 ! cellular component organization
relationship: part_of GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0022608
name: multicellular organism adhesion
namespace: biological_process
def: "The attachment of a multicellular organism to a substrate or other organism." [GOC:isa_complete]
is_a: GO:0022610 ! biological adhesion
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0022609
name: multicellular organism adhesion to substrate
namespace: biological_process
def: "The attachment of a multicellular organism to a surface or material." [GOC:isa_complete]
is_a: GO:0022608 ! multicellular organism adhesion

[Term]
id: GO:0022610
name: biological adhesion
namespace: biological_process
def: "The attachment of a cell or organism to a substrate or other organism." [GOC:isa_complete]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0022611
name: dormancy process
namespace: biological_process
def: "The process by which a dormant state is induced, maintained or broken. Dormancy is characterized by a suspension of physiological activity." [GOC:isa_complete]
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0022612
name: gland morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a gland are generated and organized. Morphogenesis pertains to the creation of form." [GOC:isa_complete]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048732 ! gland development

[Term]
id: GO:0022613
name: ribonucleoprotein complex biogenesis
namespace: biological_process
def: "The cellular process by which a complex containing RNA and proteins is synthesized, aggregates, and bonds together. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah]
subset: gosubset_prok
synonym: "ribonucleoprotein complex biogenesis and assembly" EXACT [GOC:mah]
synonym: "RNA-protein complex biogenesis" EXACT [GOC:mah]
is_a: GO:0009987 ! cellular process
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0022614
name: membrane to membrane docking
namespace: biological_process
def: "The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere." [GOC:isa_complete]
synonym: "membrane-membrane docking" EXACT []
is_a: GO:0022406 ! membrane docking

[Term]
id: GO:0022615
name: protein to membrane docking
namespace: biological_process
def: "The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete]
synonym: "protein-membrane docking" EXACT []
is_a: GO:0022406 ! membrane docking

[Term]
id: GO:0022616
name: DNA strand elongation
namespace: biological_process
def: "The DNA metabolic process by which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand." [GOC:isa_complete]
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0022617
name: extracellular matrix disassembly
namespace: biological_process
def: "A process that results in the breakdown of the extracellular matrix." [GOC:jic]
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0030198 ! extracellular matrix organization

[Term]
id: GO:0022618
name: ribonucleoprotein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]
subset: gosubset_prok
synonym: "protein-RNA complex assembly" EXACT []
synonym: "RNA-protein complex assembly" EXACT []
synonym: "RNP complex assembly" EXACT []
is_a: GO:0034622 ! cellular macromolecular complex assembly
relationship: part_of GO:0022613 ! ribonucleoprotein complex biogenesis

[Term]
id: GO:0022619
name: generative cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a generative cell. The generative cell gives rise to the sperm cells in the male gametophyte." [GOC:isa_complete]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0055046 ! microgametogenesis

[Term]
id: GO:0022620
name: vegetative cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a vegetative cell. The vegetative cell is gives rise to the pollen tube." [GOC:isa_complete]
synonym: "tube cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0055046 ! microgametogenesis

[Term]
id: GO:0022621
name: shoot system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure." [GOC:isa_complete]
is_a: GO:0048731 ! system development

[Term]
id: GO:0022622
name: root system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure." [GOC:isa_complete]
is_a: GO:0048731 ! system development

[Term]
id: GO:0022623
name: proteasome-activating nucleotidase complex
namespace: cellular_component
def: "A multisubunit complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner." [GOC:mtg_sensu, GOC:proteasome]
synonym: "PAN" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0022624 ! proteasome accessory complex

[Term]
id: GO:0022624
name: proteasome accessory complex
namespace: cellular_component
def: "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu, GOC:proteasome]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0000502 ! proteasome complex

[Term]
id: GO:0022625
name: cytosolic large ribosomal subunit
namespace: cellular_component
alt_id: GO:0005842
alt_id: GO:0009282
alt_id: GO:0030498
alt_id: GO:0030872
def: "The large subunit of the ribosome that is found in the cytosol of the cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. Examples of this component are found in Mus musculus, and in Bacterial and Archaeal species." [GOC:mtg_sensu]
synonym: "50S ribosomal subunit" NARROW []
synonym: "60S ribosomal subunit" NARROW []
synonym: "eukaryotic ribosomal LSU" NARROW []
synonym: "prokaryotic large ribosomal subunit" NARROW []
is_a: GO:0015934 ! large ribosomal subunit
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0022626 ! cytosolic ribosome

[Term]
id: GO:0022626
name: cytosolic ribosome
namespace: cellular_component
alt_id: GO:0005830
alt_id: GO:0009281
alt_id: GO:0030871
def: "A ribosome that is found in the cytosol of the cell. The cytosol is that part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. Examples of this component are found in Mus musculus, and in Bacterial and Archaeal species." [GOC:mtg_sensu]
synonym: "70S ribosome" NARROW []
synonym: "80S ribosome" NARROW []
is_a: GO:0005840 ! ribosome

[Term]
id: GO:0022627
name: cytosolic small ribosomal subunit
namespace: cellular_component
alt_id: GO:0005843
alt_id: GO:0009283
alt_id: GO:0030499
alt_id: GO:0030873
def: "The small subunit of the ribosome that is found in the cytosol of the cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. Examples of this component are found in Mus musculus, and in Bacterial and Archaeal species." [GOC:mtg_sensu]
synonym: "30S ribosomal subunit" NARROW []
synonym: "40S ribosomal subunit" NARROW []
synonym: "eukaryotic ribosomal SSU" NARROW []
synonym: "prokaryotic small ribosomal subunit" NARROW []
is_a: GO:0015935 ! small ribosomal subunit
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0022626 ! cytosolic ribosome

[Term]
id: GO:0022628
name: chloroplast large ribosomal subunit
namespace: cellular_component
def: "The large subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu]
synonym: "chloroplast ribosomal large subunit complex" EXACT []
synonym: "chloroplast ribosomal LSU complex" EXACT []
is_a: GO:0000311 ! plastid large ribosomal subunit
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0043253 ! chloroplast ribosome

[Term]
id: GO:0022629
name: chloroplast small ribosomal subunit
namespace: cellular_component
def: "The small subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu]
synonym: "chloroplast ribosomal small subunit complex" EXACT []
synonym: "chloroplast ribosomal SSU complex" EXACT []
is_a: GO:0000312 ! plastid small ribosomal subunit
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0043253 ! chloroplast ribosome

[Term]
id: GO:0022803
name: passive transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0022804
name: active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "active carrier activity" EXACT []
synonym: "carrier activity" EXACT []
synonym: "permease activity" EXACT []
synonym: "pump activity" EXACT []
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0022809
name: mobile ion carrier activity
namespace: molecular_function
def: "This is a type of carrier produced by bacteria. It enable passive transport by shielding the ion that is being transported from the lipid membrane. It carries an ion across the membrane by enclosing the ion and travelling across the membrane. It does not form a fully open pore across the membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "ionophore" BROAD []
is_a: GO:0022803 ! passive transmembrane transporter activity

[Term]
id: GO:0022810
name: membrane potential driven uniporter activity
namespace: molecular_function
def: "Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729]
synonym: "porter" BROAD []
is_a: GO:0022814 ! facilitated diffusion

[Term]
id: GO:0022814
name: facilitated diffusion
namespace: molecular_function
def: "Catalysis of the transfer of a single solute from one side of the membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged." [GOC:mtg_transport, ISBN:0815340729]
synonym: "porters" BROAD []
synonym: "uniporter activity z" EXACT []
xref: Wikipedia:Facilitated_diffusion
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0022815
name: large uncharged polar molecule transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a large uncharged polar molecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0022818
name: sodium ion uniporter activity
namespace: molecular_function
def: "Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0022810 ! membrane potential driven uniporter activity

[Term]
id: GO:0022819
name: potassium ion uniporter activity
namespace: molecular_function
def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0022810 ! membrane potential driven uniporter activity

[Term]
id: GO:0022820
name: potassium ion symporter activity
namespace: molecular_function
def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0015293 ! symporter activity

[Term]
id: GO:0022821
name: potassium ion antiporter activity
namespace: molecular_function
def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0022824
name: transmitter-gated ion channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015276 ! ligand-gated ion channel activity
is_a: GO:0022835 ! transmitter-gated channel activity

[Term]
id: GO:0022825
name: copper-exporting ATPase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it was a placeholder during work on transporter terms, and was not defined.
is_obsolete: true
replaced_by: GO:0043682

[Term]
id: GO:0022828
name: phosphorylation-gated channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022836 ! gated channel activity

[Term]
id: GO:0022829
name: wide pore channel activity
namespace: molecular_function
def: "Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "gap junction activity" NARROW []
synonym: "non-gated, wide pore channel activity" EXACT []
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0022831
name: narrow pore, gated channel activity
namespace: molecular_function
def: "Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus." [GOC:mtg_transport, ISBN:0815340729]
synonym: "ion channels" EXACT []
xref: Wikipedia:Ion_channels
is_a: GO:0022842 ! narrow pore channel activity

[Term]
id: GO:0022832
name: voltage-gated channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022836 ! gated channel activity

[Term]
id: GO:0022833
name: mechanically gated channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022836 ! gated channel activity

[Term]
id: GO:0022834
name: ligand-gated channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022836 ! gated channel activity

[Term]
id: GO:0022835
name: transmitter-gated channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
synonym: "extracellular substance gated channel activity" EXACT []
synonym: "neurotransmitter-gated channel activity" EXACT []
is_a: GO:0022834 ! ligand-gated channel activity

[Term]
id: GO:0022836
name: gated channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus." [GOC:mtg_transport]
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0022838
name: substrate-specific channel activity
namespace: molecular_function
def: "Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport]
is_a: GO:0015267 ! channel activity
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0022839
name: ion gated channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus." [GOC:mtg_transport]
is_a: GO:0022836 ! gated channel activity

[Term]
id: GO:0022840
name: leak channel activity
namespace: molecular_function
def: "Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022842 ! narrow pore channel activity

[Term]
id: GO:0022841
name: potassium ion leak channel activity
namespace: molecular_function
def: "Catalysis of the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015079 ! potassium ion transmembrane transporter activity
is_a: GO:0022840 ! leak channel activity

[Term]
id: GO:0022842
name: narrow pore channel activity
namespace: molecular_function
def: "Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0022843
name: voltage-gated cation channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0005244 ! voltage-gated ion channel activity
is_a: GO:0005261 ! cation channel activity

[Term]
id: GO:0022848
name: acetylcholine-gated cation channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when acetylcholine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022824 ! transmitter-gated ion channel activity

[Term]
id: GO:0022849
name: glutamate-gated calcium ion channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022824 ! transmitter-gated ion channel activity

[Term]
id: GO:0022850
name: serotonin-gated cation channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022824 ! transmitter-gated ion channel activity

[Term]
id: GO:0022851
name: GABA-gated chloride ion channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022824 ! transmitter-gated ion channel activity

[Term]
id: GO:0022852
name: glycine-gated chloride ion channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022824 ! transmitter-gated ion channel activity

[Term]
id: GO:0022853
name: active ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:def, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015075 ! ion transmembrane transporter activity
is_a: GO:0022804 ! active transmembrane transporter activity

[Term]
id: GO:0022854
name: active large uncharged polar molecule transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a large uncharged polar molecule from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022804 ! active transmembrane transporter activity
is_a: GO:0022815 ! large uncharged polar molecule transmembrane transporter activity

[Term]
id: GO:0022855
name: protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "glucose PTS transporter activity" EXACT []
is_a: GO:0005355 ! glucose transmembrane transporter activity
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

[Term]
id: GO:0022856
name: protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "sorbitol PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015576 ! sorbitol transmembrane transporter activity

[Term]
id: GO:0022857
name: transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0005386
alt_id: GO:0015646
def: "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0005215 ! transporter activity

[Term]
id: GO:0022858
name: alanine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity

[Term]
id: GO:0022859
name: dephosphorylation-gated channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0022836 ! gated channel activity

[Term]
id: GO:0022865
name: transmembrane electron transfer carrier
namespace: molecular_function
def: "Enables electron flow across a biological membrane, from donors localized on one side of the membrane to acceptors localized on the other side. These systems contribute to or subtract from the membrane potential, depending on the direction of electron flow. They are therefore important to cellular energetics." [GOC:mtg_transport, ISBN:0815340729, TC:5]
xref: TC:5
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0022866
name: transmembrane o1-electron transfer carrier
namespace: molecular_function
def: "Enables transfer of one electron across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.B]
synonym: "transmembrane one-electron transfer carrier" EXACT [GOC:mah]
is_a: GO:0022865 ! transmembrane electron transfer carrier

[Term]
id: GO:0022867
name: transmembrane 2-electron transfer carrier
namespace: molecular_function
def: "Enables transfer of two electrons across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.A]
synonym: "transmembrane two-electron transfer carrier" EXACT [GOC:mah]
is_a: GO:0022865 ! transmembrane electron transfer carrier

[Term]
id: GO:0022869
name: protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "lactose PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015155 ! lactose transmembrane transporter activity

[Term]
id: GO:0022870
name: protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "mannose PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015578 ! mannose transmembrane transporter activity

[Term]
id: GO:0022871
name: protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "sorbose PTS transporter activity" EXACT []
is_a: GO:0005355 ! glucose transmembrane transporter activity
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0019194 ! sorbose transmembrane transporter activity

[Term]
id: GO:0022872
name: protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "mannitol PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015575 ! mannitol transmembrane transporter activity

[Term]
id: GO:0022873
name: protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "maltose PTS transporter activity" EXACT []
is_a: GO:0005363 ! maltose transmembrane transporter activity
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

[Term]
id: GO:0022874
name: protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "cellobiose PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0019191 ! cellobiose transmembrane transporter activity

[Term]
id: GO:0022875
name: protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "galactitol PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015577 ! galactitol transmembrane transporter activity

[Term]
id: GO:0022876
name: protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "galactosamine PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0019196 ! galactosamine transmembrane transporter activity

[Term]
id: GO:0022877
name: protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "fructose PTS transporter activity" EXACT []
is_a: GO:0005353 ! fructose transmembrane transporter activity
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

[Term]
id: GO:0022878
name: protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "sucrose PTS transporter activity" EXACT []
is_a: GO:0008515 ! sucrose transmembrane transporter activity
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0019194 ! sorbose transmembrane transporter activity

[Term]
id: GO:0022879
name: protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "trehalose PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015574 ! trehalose transmembrane transporter activity
is_a: GO:0015578 ! mannose transmembrane transporter activity

[Term]
id: GO:0022880
name: protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "N-acetylglucosamine PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015572 ! N-acetylglucosamine transmembrane transporter activity
is_a: GO:0015574 ! trehalose transmembrane transporter activity

[Term]
id: GO:0022881
name: protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "N-acetylgalactosamine PTS transporter activity" EXACT []
is_a: GO:0005355 ! glucose transmembrane transporter activity
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015571 ! N-acetylgalactosamine transmembrane transporter activity

[Term]
id: GO:0022882
name: protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity
namespace: molecular_function
def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]
synonym: "beta-glucoside PTS transporter activity" EXACT []
is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity

[Term]
id: GO:0022883
name: zinc efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]
synonym: "zinc efflux permease activity" EXACT []
is_a: GO:0046583 ! cation efflux transmembrane transporter activity

[Term]
id: GO:0022884
name: macromolecule transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a macromolecule from one side of the membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0022885
name: bacteriocin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a bacteriocin from one side of the membrane to the other." [GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity

[Term]
id: GO:0022886
name: channel-forming ionophore activity
namespace: molecular_function
def: "Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive." [GOC:mtg_transport, ISBN:0815340729]
synonym: "ionophore activity" BROAD []
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0022889
name: serine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid." [GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity

[Term]
id: GO:0022890
name: inorganic cation transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0008324 ! cation transmembrane transporter activity

[Term]
id: GO:0022891
name: substrate-specific transmembrane transporter activity
namespace: molecular_function
def: "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jic, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0022857 ! transmembrane transporter activity
is_a: GO:0022892 ! substrate-specific transporter activity

[Term]
id: GO:0022892
name: substrate-specific transporter activity
namespace: molecular_function
def: "Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells." [GOC:mtg_transport]
subset: gosubset_prok
is_a: GO:0005215 ! transporter activity

[Term]
id: GO:0022893
name: low-affinity tryptophan transmembrane transporter activity
namespace: molecular_function
alt_id: GO:0015510
def: "Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:mtg_transport, ISBN:0815340729]
synonym: "low-affinity tryptophan permease activity" RELATED []
is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity

[Term]
id: GO:0022894
name: Intermediate conductance calcium-activated potassium channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754]
synonym: "IK calcium-activated potassium channel activity " EXACT []
synonym: "IK KCa channels" EXACT []
synonym: "intermdiate conductance KCa channels " EXACT []
is_a: GO:0015269 ! calcium-activated potassium channel activity

[Term]
id: GO:0022897
name: proton-dependent peptide secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport]
subset: gosubset_prok
synonym: "hydrogen/oligopeptide symporter" RELATED []
is_a: GO:0015197 ! peptide transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0022898
name: regulation of transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport]
subset: gosubset_prok
is_a: GO:0032409 ! regulation of transporter activity
is_a: GO:0034762 ! regulation of transmembrane transport

[Term]
id: GO:0022900
name: electron transport chain
namespace: biological_process
def: "A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport]
subset: gosubset_prok
xref: Wikipedia:Electron_transport_chain
is_a: GO:0006091 ! generation of precursor metabolites and energy
is_a: GO:0055114 ! oxidation reduction

[Term]
id: GO:0022904
name: respiratory electron transport chain
namespace: biological_process
def: "A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "6-phosphofructokinase reduction" RELATED []
synonym: "dihydrobiopterin reduction" RELATED []
synonym: "dihydrolipoamide reduction" RELATED []
synonym: "dihydrolipoylprotein reduction" RELATED []
synonym: "dihydropteridine reduction" RELATED []
synonym: "electron transfer" EXACT []
synonym: "other pathways of electron transport" RELATED []
synonym: "oxidized glutathione reduction" RELATED []
synonym: "protein-disulfide reduction" RELATED []
xref: Wikipedia:Electron_transfer
is_a: GO:0022900 ! electron transport chain
relationship: part_of GO:0045333 ! cellular respiration

[Term]
id: GO:0023002
name: nuclear migration to embryo sac poles
namespace: biological_process
def: "Migration of the nuclei of the two-nucleate embryo sac to opposite poles of the cell." [GOC:jic, GOC:mtg_plant, ISBN:047186840X]
synonym: "nuclear migration to female gametophyte poles" EXACT []
synonym: "nuclear migration to megagametophyte poles" EXACT []
synonym: "nucleus migration to embryo sac poles" EXACT []
synonym: "nucleus migration to female gametophyte poles" EXACT []
synonym: "nucleus migration to megagametophyte poles" EXACT []
is_a: GO:0009562 ! embryo sac nuclear migration

[Term]
id: GO:0023003
name: nuclear migration to the embryo sac center
namespace: biological_process
def: "Migration of one of the four nuclei at each pole of the eight-nucleate embryo sac, to the center of the cell." [GOC:jic, GOC:mtg_plant, ISBN:047186840X]
synonym: "nuclear migration to the embryo sac centre" EXACT []
synonym: "nuclear migration to the female gametophyte center" EXACT []
synonym: "nuclear migration to the female gametophyte centre" EXACT []
synonym: "nuclear migration to the megagametophyte center" EXACT []
synonym: "nuclear migration to the megagametophyte centre" EXACT []
synonym: "nucleus migration to the female gametophyte center" EXACT []
synonym: "nucleus migration to the female gametophyte centre" EXACT []
is_a: GO:0009562 ! embryo sac nuclear migration

[Term]
id: GO:0023004
name: activation of dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that initiates the dopamine receptor protein signaling pathway through stimulation of the dopamine receptor." [GOC:mtg_signaling]
synonym: "initiation of dopamine receptor signaling pathway" RELATED []
synonym: "stimulation of dopamine receptor signaling pathway" EXACT []
is_a: GO:0023005 ! signal initiation by neurotransmitter
is_a: GO:0060161 ! positive regulation of dopamine receptor signaling pathway

[Term]
id: GO:0023005
name: signal initiation by neurotransmitter
namespace: biological_process
def: "The process whereby a neurotransmitter signal causes activation of a receptor." [GOC:mtg_signal]
is_a: GO:0023038 ! signal initiation by diffusible mediator

[Term]
id: GO:0023006
name: signal initiation by amino acid
namespace: biological_process
def: "The process whereby an amino acid signal causes activation of a receptor." [GOC:mtg_signal]
is_a: GO:0023038 ! signal initiation by diffusible mediator

[Term]
id: GO:0023007
name: ligand binding to T cell receptor
namespace: biological_process
def: "Binding of a diffusible ligand to a T cell receptor as part of a signaling process." [GOC:jid, GOC:mtg_signal]
is_a: GO:0050862 ! positive regulation of T cell receptor signaling pathway

[Term]
id: GO:0023009
name: initiation of T cell receptor signaling
namespace: biological_process
def: "The process whereby a signal causes activation of T cell receptor signaling." [GOC:mtg_signal]
is_a: GO:0023049 ! signal initiation by protein/peptide mediator

[Term]
id: GO:0023010
name: regulation of initiation of T cell receptor signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the initiation of T cell receptor signaling." [GOC:mtg_signal]
is_a: GO:0023009 ! initiation of T cell receptor signaling

[Term]
id: GO:0023011
name: positive regulation of initiation of T cell receptor signaling
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the initiation of T cell receptor signaling." [GOC:mtg_signal]
is_a: GO:0023010 ! regulation of initiation of T cell receptor signaling

[Term]
id: GO:0023012
name: initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor
namespace: biological_process
def: "The process whereby binding of an MHC complex to T cell receptor causes activation of T cell receptor signaling." [GOC:mtg_signal]
is_a: GO:0023009 ! initiation of T cell receptor signaling

[Term]
id: GO:0023013
name: signal transmission via intracellular cascade
namespace: biological_process
def: "The process whereby a signal is conveyed via an intracellular cascade." [GOC:mtg_signal]
is_a: GO:0023060 ! signal transmission

[Term]
id: GO:0023014
name: signal transmission via phosphorylation event
namespace: biological_process
def: "The process whereby a signal is conveyed via a phosphorylation event." [GOC:mtg_signal]
is_a: GO:0023060 ! signal transmission

[Term]
id: GO:0023015
name: signal transmission via a cis-phosphorylation event
namespace: biological_process
def: "The process whereby a signal is conveyed via a cis-phosphorylation event." [GOC:mtg_signal]
is_a: GO:0023014 ! signal transmission via phosphorylation event

[Term]
id: GO:0023016
name: signal transmission via a trans-phosphorylation event
namespace: biological_process
def: "The process whereby a signal is conveyed via a trans-phosphorylation event." [GOC:mtg_signal]
is_a: GO:0023014 ! signal transmission via phosphorylation event

[Term]
id: GO:0023017
name: signal transmission via diffusible molecule
namespace: biological_process
def: "The process whereby a signal is conveyed via a diffusible molecule." [GOC:mtg_signal]
synonym: "signaling via diffusible mediator" EXACT []
is_a: GO:0023060 ! signal transmission

[Term]
id: GO:0023018
name: T cell activation of signal transmission via diffusible molecule
namespace: biological_process
def: "The process whereby signal transmission via a diffusible molecule is initiated by a T cell." [GOC:mtg_signal]
is_a: GO:0023017 ! signal transmission via diffusible molecule

[Term]
id: GO:0023019
name: regulation of gene expression as a consequence of signal transmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process whereby a signal is released and/or conveyed from one location to another." [GOC:mtg_signal]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0023050 ! consequence of signal transmission

[Term]
id: GO:0023020
name: regulation of gene expression as a consequence of T cell signal transmission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process whereby a T cell signal is released and/or conveyed from one location to another." [GOC:mtg_signal]
is_a: GO:0023019 ! regulation of gene expression as a consequence of signal transmission

[Term]
id: GO:0023021
name: termination of signal transduction
namespace: biological_process
def: "The signaling process whereby signal transduction is brought to an end rather than being reversibly modulated." [GOC:mtg_signal]
comment: Note that this term encompasses both the control point when the instruction is given for the process to cease and the actual cessation of the process. A process can persist for some time after that signal that induced the process is withdrawn.
is_a: GO:0023046 ! signaling process

[Term]
id: GO:0023022
name: termination of T cell signal transduction
namespace: biological_process
def: "The signaling process whereby T cell signal transduction is brought to an end rather than being reversibly modulated." [GOC:mtg_signal]
is_a: GO:0023021 ! termination of signal transduction
is_a: GO:0050860 ! negative regulation of T cell receptor signaling pathway

[Term]
id: GO:0023023
name: MHC protein complex binding
namespace: molecular_function
def: "Interacting selectively with the major histocompatibility complex." [GOC:mtg_signal]
is_a: GO:0003823 ! antigen binding

[Term]
id: GO:0023024
name: MHC class I protein complex binding
namespace: molecular_function
def: "Interacting selectively with the class I major histocompatibility complex." [GOC:mtg_signal]
is_a: GO:0023023 ! MHC protein complex binding

[Term]
id: GO:0023025
name: MHC class Ib protein complex binding
namespace: molecular_function
def: "Interacting selectively with the class Ib major histocompatibility complex." [GOC:mtg_signal]
is_a: GO:0023023 ! MHC protein complex binding

[Term]
id: GO:0023026
name: MHC class II protein complex binding
namespace: molecular_function
def: "Interacting selectively with the class II major histocompatibility complex." [GOC:mtg_signal]
is_a: GO:0023023 ! MHC protein complex binding

[Term]
id: GO:0023027
name: MHC class I protein binding, via antigen binding groove
namespace: molecular_function
def: "Interacting selectively with major histocompatibility complex class I molecules via the antigen binding groove." [GOC:mtg_signal]
is_a: GO:0042288 ! MHC class I protein binding
relationship: part_of GO:0023024 ! MHC class I protein complex binding

[Term]
id: GO:0023028
name: MHC class I protein binding, via lateral surface
namespace: molecular_function
def: "Interacting selectively with major histocompatibility complex class I molecules via the lateral surface." [GOC:mtg_signal]
is_a: GO:0042288 ! MHC class I protein binding

[Term]
id: GO:0023029
name: MHC class Ib protein binding
namespace: molecular_function
def: "Interacting selectively with major histocompatibility complex class Ib molecules." [GOC:mtg_signal]
is_a: GO:0042287 ! MHC protein binding

[Term]
id: GO:0023030
name: MHC class Ib protein binding, via antigen binding groove
namespace: molecular_function
def: "Interacting selectively with major histocompatibility complex class Ib molecules via the antigen binding groove." [GOC:mtg_signal]
is_a: GO:0023029 ! MHC class Ib protein binding
relationship: part_of GO:0023025 ! MHC class Ib protein complex binding

[Term]
id: GO:0023031
name: MHC class Ib protein binding, via lateral surface
namespace: molecular_function
def: "Interacting selectively with major histocompatibility complex class Ib molecules via the lateral surface." [GOC:mtg_signal]
is_a: GO:0023029 ! MHC class Ib protein binding

[Term]
id: GO:0023032
name: behavioral signaling
namespace: biological_process
def: "The entirety of the behavioral process whereby information is sent between living organisms." [GOC:mtg_signal]
is_a: GO:0023052 ! signaling

[Term]
id: GO:0023033
name: signaling pathway
namespace: biological_process
def: "The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms." [GOC:mtg_signal]
is_a: GO:0023052 ! signaling

[Term]
id: GO:0023034
name: intracellular signaling pathway
namespace: biological_process
def: "The series of molecular events whereby information is sent from one location to another within a living organism." [GOC:mtg_signal]
synonym: "intracellular signal transduction pathway" RELATED []
is_a: GO:0023033 ! signaling pathway

[Term]
id: GO:0023035
name: CD40 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to the receptor CD40." [GOC:mtg_signal]
is_a: GO:0023034 ! intracellular signaling pathway

[Term]
id: GO:0023036
name: initiation of signal transduction
namespace: biological_process
def: "The process whereby a signal causes activation of a receptor, for example, via a conformation change." [GOC:mtg_sig]
comment: Note that this term is intended for the annotation of both ligands and receptors.
is_a: GO:0023046 ! signaling process
relationship: part_of GO:0007165 ! signal transduction

[Term]
id: GO:0023037
name: signal initiation by light
namespace: biological_process
def: "The process whereby a light signal causes activation of a receptor." [GOC:mtg_signal]
is_a: GO:0023036 ! initiation of signal transduction

[Term]
id: GO:0023038
name: signal initiation by diffusible mediator
namespace: biological_process
def: "The process whereby a diffusible signal causes activation of a receptor." [GOC:mtg_signal]
is_a: GO:0023036 ! initiation of signal transduction

[Term]
id: GO:0023039
name: signal initiation by physical damage
namespace: biological_process
def: "The process whereby a physical damage signal causes activation of a receptor." [GOC:mtg_signal]
is_a: GO:0023053 ! signal initiation by mechanical effect

[Term]
id: GO:0023040
name: signaling via ionic flux
namespace: biological_process
def: "The process whereby information is sent from one location to another, within a living organism or between living organisms, via ionic flux." [GOC:mtg_signal]
is_a: GO:0023017 ! signal transmission via diffusible molecule

[Term]
id: GO:0023041
name: neuronal signal transduction
namespace: biological_process
def: "The process whereby an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular." [GOC:mtg_signal]
is_a: GO:0007165 ! signal transduction
is_a: GO:0023040 ! signaling via ionic flux

[Term]
id: GO:0023042
name: signaling via protein/peptide mediator
namespace: biological_process
def: "The process whereby information is sent from one location to another, within a living organism or between living organisms, via a protein/peptide mediator." [GOC:mtg_signal]
is_a: GO:0023017 ! signal transmission via diffusible molecule

[Term]
id: GO:0023043
name: signaling via lipid mediator
namespace: biological_process
def: "The process whereby information is sent from one location to another, within a living organism or between living organisms, via a lipid mediator." [GOC:mtg_signal]
is_a: GO:0023017 ! signal transmission via diffusible molecule

[Term]
id: GO:0023044
name: signaling via chemical mediator
namespace: biological_process
def: "The process whereby information is sent from one location to another, within a living organism or between living organisms, via a chemical mediator." [GOC:mtg_signal]
is_a: GO:0023017 ! signal transmission via diffusible molecule

[Term]
id: GO:0023045
name: signal transmission via conformational transition
namespace: biological_process
def: "The process whereby a signal is conveyed via a conformational transition." [GOC:mtg_signal]
is_a: GO:0023060 ! signal transmission

[Term]
id: GO:0023046
name: signaling process
namespace: biological_process
def: "Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information." [GOC:mtg_signaling]
is_a: GO:0008150 ! biological_process
relationship: part_of GO:0023052 ! signaling

[Term]
id: GO:0023047
name: signal initiation by chemical mediator
namespace: biological_process
def: "The process whereby a chemical signal causes activation of a receptor." [GOC:mtg_signal]
is_a: GO:0023038 ! signal initiation by diffusible mediator

[Term]
id: GO:0023048
name: signal initiation by lipid mediator
namespace: biological_process
def: "The process whereby a lipid signal causes activation of a receptor." [GOC:mtg_signal]
is_a: GO:0023038 ! signal initiation by diffusible mediator

[Term]
id: GO:0023049
name: signal initiation by protein/peptide mediator
namespace: biological_process
def: "The process whereby a protein/peptide signal causes activation of a receptor." [GOC:mtg_signal]
is_a: GO:0023038 ! signal initiation by diffusible mediator

[Term]
id: GO:0023050
name: consequence of signal transmission
namespace: biological_process
def: "The steps whereby the downstream processes started by a signal are brought to a conclusion. Examples include destruction of cAMP by PDE, or endocytosis resulting from receptor phosphorylation. The termination process ends when the receptor has returned to its inactive state." [GOC:mtg_signaling]
comment: Note that most or all examples of this process are regulation steps.
synonym: "signal termination" EXACT []
is_a: GO:0023046 ! signaling process
relationship: part_of GO:0023060 ! signal transmission

[Term]
id: GO:0023051
name: regulation of signaling process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0023046 ! signaling process

[Term]
id: GO:0023052
name: signaling
namespace: biological_process
def: "The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered." [GOC:mtg_signaling]
comment: The synthesis of the signal is not, in general, considered to be part of this process, but in some cases it is. Synthesis of insulin is not considered to be part of the insulin signaling pathway, and the insulin is assumed to have been made before the signaling process starts.
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0023053
name: signal initiation by mechanical effect
namespace: biological_process
def: "The process whereby a mechanical signal causes activation of a receptor." [GOC:mtg_signal]
is_a: GO:0023036 ! initiation of signal transduction

[Term]
id: GO:0023054
name: signal initiation by stretch effect
namespace: biological_process
def: "The process whereby a stretch signal causes activation of a receptor." [GOC:mtg_signal]
is_a: GO:0023053 ! signal initiation by mechanical effect

[Term]
id: GO:0023055
name: signal initiation by peptide hormone
namespace: biological_process
def: "The process whereby a signal is initiated by a peptide hormone." [GOC:signaling]
is_a: GO:0023049 ! signal initiation by protein/peptide mediator

[Term]
id: GO:0023056
name: positive regulation of signaling process
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
is_a: GO:0023051 ! regulation of signaling process

[Term]
id: GO:0023057
name: negative regulation of signaling process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal]
is_a: GO:0023051 ! regulation of signaling process

[Term]
id: GO:0023058
name: adaptation of signaling pathway
namespace: biological_process
def: "The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_sig]
is_a: GO:0009966 ! regulation of signal transduction

[Term]
id: GO:0023059
name: positive adaptation of signaling pathway
namespace: biological_process
def: "The positive regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_sig]
is_a: GO:0023056 ! positive regulation of signaling process
is_a: GO:0023058 ! adaptation of signaling pathway

[Term]
id: GO:0023060
name: signal transmission
namespace: biological_process
def: "The process whereby a signal is released and/or conveyed from one location to another. The process terminates at the end of the sub-process of signal transduction, when the function of the cell has been altered as a consequence of receipt of the signal." [GOC:mtg_signal]
is_a: GO:0023046 ! signaling process

[Term]
id: GO:0023061
name: signal release
namespace: biological_process
def: "The process whereby a signal is secreted or discharged into the extracellular medium from a cellular source." [GOC:mtg_signaling]
is_a: GO:0023046 ! signaling process
relationship: part_of GO:0023060 ! signal transmission

[Term]
id: GO:0023062
name: signal transmission via transcytosis
namespace: biological_process
def: "The process whereby a signal is conveyed via transcytosis." [GOC:mtg_signal]
is_a: GO:0023060 ! signal transmission

[Term]
id: GO:0023065
name: signal transmission via blood
namespace: biological_process
def: "The process whereby a signal is conveyed via blood." [GOC:mtg_signal]
is_a: GO:0023066 ! signal transmission via vascular system

[Term]
id: GO:0023066
name: signal transmission via vascular system
namespace: biological_process
def: "The process whereby a signal is conveyed via the vascular system." [GOC:mtg_signal]
is_a: GO:0023060 ! signal transmission

[Term]
id: GO:0023067
name: signal transmission via lymphatic system
namespace: biological_process
def: "The process whereby a signal is conveyed via the lymphatic system." [GOC:mtg_signal]
is_a: GO:0023066 ! signal transmission via vascular system

[Term]
id: GO:0023068
name: signal transmission via phloem
namespace: biological_process
def: "The process whereby a signal is conveyed via the phloem." [GOC:mtg_signal]
is_a: GO:0023066 ! signal transmission via vascular system

[Term]
id: GO:0023069
name: signal transmission via xylem
namespace: biological_process
def: "The process whereby a signal is conveyed via the xylem." [GOC:mtg_signal]
is_a: GO:0023066 ! signal transmission via vascular system

[Term]
id: GO:0023070
name: signal transmission via air
namespace: biological_process
def: "The process whereby a signal is conveyed via the air." [GOC:mtg_signal]
is_a: GO:0023060 ! signal transmission

[Term]
id: GO:0030001
name: metal ion transport
namespace: biological_process
def: "The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "heavy metal ion transport" NARROW []
is_a: GO:0006812 ! cation transport

[Term]
id: GO:0030002
name: cellular anion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of anions at the level of a cell." [GOC:ceb, GOC:mah]
is_a: GO:0006873 ! cellular ion homeostasis
is_a: GO:0055081 ! anion homeostasis

[Term]
id: GO:0030003
name: cellular cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of cations at the level of a cell." [GOC:ceb, GOC:mah]
subset: gosubset_prok
is_a: GO:0006873 ! cellular ion homeostasis
is_a: GO:0055080 ! cation homeostasis

[Term]
id: GO:0030004
name: cellular monovalent inorganic cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of monovalent inorganic cations at the level of a cell." [GOC:ai, GOC:mah]
subset: gosubset_prok
is_a: GO:0030003 ! cellular cation homeostasis
is_a: GO:0055067 ! monovalent inorganic cation homeostasis

[Term]
id: GO:0030005
name: cellular di-, tri-valent inorganic cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of divalent or trivalent cations at the level of a cell." [GOC:ceb, GOC:mah]
subset: gosubset_prok
is_a: GO:0030003 ! cellular cation homeostasis
is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis

[Term]
id: GO:0030006
name: heavy cellular metal ion homeostasis
namespace: biological_process
def: "OBSOLETE. Regulation of the levels, transport, and metabolism of ions of a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah]
comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information).
is_obsolete: true
consider: GO:0006875

[Term]
id: GO:0030007
name: cellular potassium ion homeostasis
namespace: biological_process
alt_id: GO:0017079
def: "Any process involved in the maintenance of an internal equilibrium of potassium ions at the level of a cell." [GOC:mah]
is_a: GO:0006875 ! cellular metal ion homeostasis
is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis
is_a: GO:0055075 ! potassium ion homeostasis

[Term]
id: GO:0030008
name: TRAPP complex
namespace: cellular_component
def: "A large complex present on the cis-Golgi that acts prior to SNARE complex assembly to mediate vesicle docking and fusion. Ras guanyl-nucleotide exchange factor activity has been demonstrated for this complex in S. cerevisiae." [GOC:vw, PMID:17287728, PMID:9564032]
synonym: "transport protein particle" EXACT []
synonym: "TRAPP1" NARROW [GOC:vw]
synonym: "TRAPP2" NARROW [GOC:vw]
xref: Wikipedia:TRAPP_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0005801 ! cis-Golgi network

[Term]
id: GO:0030009
name: complement factor H activity
namespace: molecular_function
def: "OBSOLETE. A cofactor for the serine protease complement factor I." [ISBN:0198547684]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0006956

[Term]
id: GO:0030010
name: establishment of cell polarity
namespace: biological_process
alt_id: GO:0000283
alt_id: GO:0030468
def: "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
synonym: "bud site selection/establishment of cell polarity" NARROW []
synonym: "cell polarization" EXACT []
is_a: GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0030011
name: maintenance of cell polarity
namespace: biological_process
alt_id: GO:0030013
alt_id: GO:0030469
def: "The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah]
is_a: GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0030014
name: CCR4-NOT complex
namespace: cellular_component
def: "A large multimeric transcription factor complex that can regulate transcription positively or negatively; consists of a core complex plus additional proteins; may interact with other proteins to control initiation of transcription. In Saccharomyces the core complex comprises Ccr4p, Caf1p, Not1p, Not2p, Not3p, Not4p, and Not5p; Caf4p, Caf16p, and several less well characterized proteins." [PMID:11113136]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0030015
name: CCR4-NOT core complex
namespace: cellular_component
def: "The core of the CCR4-NOT transcription factor complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Not1p, Not2p, Not3p, Not4p, and Not5p." [PMID:11113136]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
relationship: part_of GO:0030014 ! CCR4-NOT complex

[Term]
id: GO:0030016
name: myofibril
namespace: cellular_component
def: "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194]
synonym: "striated muscle fiber" EXACT []
synonym: "striated muscle fibre" EXACT []
xref: Wikipedia:Myofibril
is_a: GO:0043292 ! contractile fiber

[Term]
id: GO:0030017
name: sarcomere
namespace: cellular_component
def: "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194]
xref: Wikipedia:Sarcomere
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030016 ! myofibril

[Term]
id: GO:0030018
name: Z disc
namespace: cellular_component
def: "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]
synonym: "Z band" EXACT []
synonym: "Z disk" EXACT []
synonym: "Z line" EXACT []
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0031674 ! I band

[Term]
id: GO:0030019
name: tryptase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin." [EC:3.4.21.59]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "lung tryptase activity" NARROW [EC:3.4.21.59]
synonym: "mast cell neutral proteinase activity" EXACT [EC:3.4.21.59]
synonym: "mast cell protease II activity" NARROW [EC:3.4.21.59]
synonym: "mast cell proteinase II" RELATED [EC:3.4.21.59]
synonym: "mast cell serine proteinase II" RELATED [EC:3.4.21.59]
synonym: "mast cell serine proteinase tryptase activity" EXACT [EC:3.4.21.59]
synonym: "mast cell tryptase activity" NARROW [EC:3.4.21.59]
synonym: "pituitary tryptase activity" NARROW [EC:3.4.21.59]
synonym: "rat mast cell protease II" RELATED [EC:3.4.21.59]
synonym: "skin tryptase activity" NARROW [EC:3.4.21.59]
synonym: "tryptase M" RELATED [EC:3.4.21.59]
xref: EC:3.4.21.59
xref: MetaCyc:3.4.21.59-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0030020
name: extracellular matrix structural constituent conferring tensile strength
namespace: molecular_function
def: "A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress." [GOC:mah, ISBN:0815316194]
is_a: GO:0005201 ! extracellular matrix structural constituent

[Term]
id: GO:0030021
name: extracellular matrix structural constituent conferring compression resistance
namespace: molecular_function
def: "A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan." [GOC:mah, ISBN:0815316194]
is_a: GO:0005201 ! extracellular matrix structural constituent

[Term]
id: GO:0030022
name: adhesive extracellular matrix constituent
namespace: molecular_function
def: "OBSOLETE. A constituent of the extracellular matrix that facilitates attachment of cells to the matrix." [GOC:mah, ISBN:0815316194]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
replaced_by: GO:0005578
replaced_by: GO:0030674
replaced_by: GO:0050839
replaced_by: GO:0050840

[Term]
id: GO:0030023
name: extracellular matrix constituent conferring elasticity
namespace: molecular_function
def: "A component of the extracellular matrix that enables the matrix to recoil after transient stretching." [GOC:mah, ISBN:0815316194]
synonym: "elastin" RELATED []
is_a: GO:0005201 ! extracellular matrix structural constituent

[Term]
id: GO:0030026
name: cellular manganese ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of manganese ions at the level of a cell." [GOC:mah]
subset: gosubset_prok
synonym: "manganese homeostasis" BROAD []
is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis
is_a: GO:0055071 ! manganese ion homeostasis

[Term]
id: GO:0030027
name: lamellipodium
namespace: cellular_component
def: "A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments." [ISBN:0815316194]
xref: Wikipedia:Lamellipodia
is_a: GO:0042995 ! cell projection
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0030029
name: actin filament-based process
namespace: biological_process
def: "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah]
synonym: "microfilament-based process" RELATED []
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0030030
name: cell projection organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
subset: gosubset_prok
synonym: "cell projection organisation" EXACT [GOC:curators]
synonym: "cell projection organization and biogenesis" RELATED [GOC:mah]
synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009987 ! cellular process
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0030031
name: cell projection assembly
namespace: biological_process
def: "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
subset: gosubset_prok
synonym: "cell projection biogenesis" RELATED [GOC:mah]
synonym: "formation of a cell surface projection" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0030032
name: lamellipodium assembly
namespace: biological_process
def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:mah, ISBN:0815316194]
synonym: "lamellipodium biogenesis" RELATED [GOC:mah]
synonym: "lamellipodium biosynthesis" EXACT []
synonym: "lamellipodium formation" EXACT []
is_a: GO:0030031 ! cell projection assembly

[Term]
id: GO:0030033
name: microvillus assembly
namespace: biological_process
def: "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah, ISBN:0815316194]
synonym: "microvillus biogenesis" RELATED [GOC:mah]
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0032528 ! microvillus organization

[Term]
id: GO:0030034
name: microvillar actin bundle assembly
namespace: biological_process
def: "Assembly of the parallel bundle of actin filaments at the core of a microvillus." [GOC:mah]
is_a: GO:0051017 ! actin filament bundle assembly
relationship: part_of GO:0030033 ! microvillus assembly

[Term]
id: GO:0030035
name: microspike assembly
namespace: biological_process
def: "Formation of a microspike, a thin, stiff projection extended from the surface of a migrating cell." [GOC:mah, ISBN:0815316194]
synonym: "microspike biogenesis" RELATED [GOC:mah]
synonym: "microspike biosynthesis" EXACT []
synonym: "microspike formation" EXACT []
is_a: GO:0030031 ! cell projection assembly

[Term]
id: GO:0030036
name: actin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
synonym: "actin cytoskeleton organisation" EXACT [GOC:curators]
synonym: "actin cytoskeleton organization and biogenesis" RELATED [GOC:mah]
synonym: "actin modulating activity" RELATED []
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0030029 ! actin filament-based process

[Term]
id: GO:0030037
name: actin filament reorganization during cell cycle
namespace: biological_process
def: "The cell cycle process whereby rearrangement of the spatial distribution of actin filaments and associated proteins occurs." [GOC:mah]
is_a: GO:0007015 ! actin filament organization
is_a: GO:0022402 ! cell cycle process
is_a: GO:0031532 ! actin cytoskeleton reorganization

[Term]
id: GO:0030038
name: contractile actin filament bundle assembly
namespace: biological_process
def: "Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:mah, ISBN:0815316194]
is_a: GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0030039
name: DNA unwinding factor
namespace: molecular_function
alt_id: GO:0017152
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it does not represent a true molecular function.
is_obsolete: true
replaced_by: GO:0006268

[Term]
id: GO:0030041
name: actin filament polymerization
namespace: biological_process
def: "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
synonym: "actin polymerization" EXACT []
synonym: "actin polymerizing activity" RELATED []
is_a: GO:0008154 ! actin polymerization or depolymerization
is_a: GO:0051258 ! protein polymerization

[Term]
id: GO:0030042
name: actin filament depolymerization
namespace: biological_process
def: "Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]
synonym: "actin depolymerization" EXACT []
synonym: "actin depolymerizing activity" RELATED []
is_a: GO:0008154 ! actin polymerization or depolymerization
is_a: GO:0051261 ! protein depolymerization

[Term]
id: GO:0030043
name: actin filament fragmentation
namespace: biological_process
def: "The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins." [GOC:mah, ISBN:0815316194]
is_a: GO:0030042 ! actin filament depolymerization

[Term]
id: GO:0030046
name: parallel actin filament bundle assembly
namespace: biological_process
def: "Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity." [GOC:mah, ISBN:0815316194]
is_a: GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0030047
name: actin modification
namespace: biological_process
alt_id: GO:0007013
def: "Covalent modification of an actin molecule." [GOC:mah]
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0030048
name: actin filament-based movement
namespace: biological_process
def: "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:mah]
is_a: GO:0030029 ! actin filament-based process
is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport

[Term]
id: GO:0030049
name: muscle filament sliding
namespace: biological_process
def: "The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated." [GOC:mah, GOC:mtg_muscle, ISBN:0815316194]
xref: Reactome:390522 "Striated Muscle Contraction"
xref: Reactome:448874 "Striated Muscle Contraction"
xref: Reactome:469991 "Striated Muscle Contraction"
xref: Reactome:487696 "Striated Muscle Contraction"
xref: Reactome:507648 "Striated Muscle Contraction"
is_a: GO:0033275 ! actin-myosin filament sliding
relationship: part_of GO:0006936 ! muscle contraction

[Term]
id: GO:0030050
name: vesicle transport along actin filament
namespace: biological_process
def: "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah]
is_a: GO:0030048 ! actin filament-based movement
is_a: GO:0051648 ! vesicle localization

[Term]
id: GO:0030051
name: FK506-sensitive peptidyl-prolyl cis-trans isomerase
namespace: molecular_function
def: "OBSOLETE. Interacts selectively with the immunosuppressant FK506, and possesses peptidyl-prolyl isomerase activity (catalysis of the reaction: peptidoproline (omega=180) = peptidylproline (omega=0))." [EC:5.2.1.8, ISBN:0198596732]
comment: This term was made obsolete because it represents a gene product and not a function.
synonym: "FK506 binding protein" RELATED []
synonym: "FKBP" RELATED []
is_obsolete: true
replaced_by: GO:0003755
replaced_by: GO:0005528

[Term]
id: GO:0030052
name: parvulin
namespace: molecular_function
def: "OBSOLETE. A peptidyl-prolyl isomerase isolated from Escherichia coli. It does not have any function as an immunophilin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it describes a gene product.
is_obsolete: true
replaced_by: GO:0003755

[Term]
id: GO:0030053
name: immunophilin
namespace: molecular_function
def: "OBSOLETE. Any member of a family of receptors that includes the major FK506 binding protein FKBP and cyclophilin. These two proteins are unrelated in amino-acid sequence, but both possess peptidyl-prolyl isomerase activity which is blocked by immunosuppressants that block signal-transduction pathways leading to T cell activation such as FK506 and rapamycin, which block FKBP, or cyclosporin A, which blocks cyclophilin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it does not represent a molecular function.
is_obsolete: true
consider: GO:0003755
consider: GO:0004872

[Term]
id: GO:0030054
name: cell junction
namespace: cellular_component
def: "A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: Wikipedia:Cell_junction
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0030055
name: cell-substrate junction
namespace: cellular_component
def: "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:hb, GOC:mah]
synonym: "cell-matrix junction" EXACT []
is_a: GO:0030054 ! cell junction
relationship: part_of GO:0016323 ! basolateral plasma membrane

[Term]
id: GO:0030056
name: hemidesmosome
namespace: cellular_component
def: "A cell-substrate junction that forms a point of contact between the basal surface of epithelial cells and the basal lamina. Morphologically resembles desmosomes; attached to intermediate filaments." [ISBN:0815316208]
synonym: "hemi-adherens junction" RELATED [http://www.wormatlas.org/glossaries/hglossary.htm#hemiadherensjunction]
xref: Wikipedia:Hemidesmosome
is_a: GO:0030055 ! cell-substrate junction
relationship: part_of GO:0009925 ! basal plasma membrane

[Term]
id: GO:0030057
name: desmosome
namespace: cellular_component
def: "A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181]
synonym: "macula adherens" EXACT []
synonym: "spot desmosome" EXACT []
xref: Wikipedia:Desmosome
is_a: GO:0005911 ! cell-cell junction
is_a: GO:0070161 ! anchoring junction
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0030058
name: amine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: R-CH2-NH2 + H2O + acceptor = R-CHO + NH3 + reduced acceptor." [EC:1.4.99.3]
subset: gosubset_prok
synonym: "amine: (acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.3]
synonym: "MADH activity" EXACT [EC:1.4.99.3]
synonym: "methylamine dehydrogenase activity" EXACT [EC:1.4.99.3]
synonym: "primary-amine dehydrogenase activity" BROAD [EC:1.4.99.3]
synonym: "primary-amine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.3]
synonym: "primary-amine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.3]
xref: EC:1.4.99.3
xref: MetaCyc:AMINE-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0058
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0030059
name: aralkylamine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: R-CH2-NH2 + H2O + acceptor = R-CHO + NH3 + reduced acceptor; acts on aromatic amines and, more slowly, on some long-chain aliphatic amines, but not on methylamine or ethylamine." [EC:1.4.99.4]
synonym: "aralkylamine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.4]
synonym: "aralkylamine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.4]
synonym: "aromatic amine dehydrogenase activity" EXACT [EC:1.4.99.4]
synonym: "dehydrogenase, arylamine" EXACT [EC:1.4.99.4]
synonym: "tyramine dehydrogenase activity" EXACT [EC:1.4.99.4]
xref: EC:1.4.99.4
xref: MetaCyc:ARALKYLAMINE-DEHYDROGENASE-RXN
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0030060
name: L-malate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids." [EC:1.1.1.37]
subset: gosubset_prok
synonym: "(S)-malate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.37]
synonym: "L-malate-NAD+ oxidoreductase activity" EXACT [EC:1.1.1.37]
synonym: "malate (NAD) dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "malic acid dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "malic dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "MDH" RELATED [EC:1.1.1.37]
synonym: "NAD-dependent malate dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "NAD-dependent malic dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "NAD-L-malate dehydrogenase activity" EXACT []
synonym: "NAD-linked malate dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "NAD-malate dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "NAD-malic dehydrogenase activity" EXACT [EC:1.1.1.37]
synonym: "NAD-specific malate dehydrogenase activity" EXACT [EC:1.1.1.37]
xref: EC:1.1.1.37
xref: MetaCyc:MALATE-DEH-RXN
xref: Reactome:19541 "L-malate dehydrogenase activity"
is_a: GO:0016615 ! malate dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0030061
name: mitochondrial crista
namespace: cellular_component
def: "Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'.
synonym: "mitochondrial cristae" EXACT []
xref: NIF_Subcellular:sao333328131
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0030062
name: mitochondrial tricarboxylic acid cycle enzyme complex
namespace: cellular_component
def: "Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu]
synonym: "TCA cycle enzyme complex" BROAD []
is_a: GO:0044429 ! mitochondrial part
is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0030063
name: murein sacculus
namespace: cellular_component
def: "OBSOLETE. A structure formed of the cross-linked polymer peptidoglycan (also called murein) that forms a covalently closed net around a bacterial cell, and imparts structural stability to the bacterial cell wall." [GOC:mah, PMID:9529891]
comment: This term was made obsolete because it was defined inaccurately.
synonym: "peptidoglycan layer" EXACT []
is_obsolete: true
consider: GO:0009276

[Term]
id: GO:0030064
name: cell wall inner membrane
namespace: cellular_component
def: "OBSOLETE. The peptidoglycan layer of the cell wall of Gram-negative bacteria." [ISBN:0135712254]
comment: This term was made obsolete because it was defined inaccurately.
is_obsolete: true
consider: GO:0009276

[Term]
id: GO:0030066
name: cytochrome b6
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
synonym: "cytochrome b-563" RELATED []
is_obsolete: true
replaced_by: GO:0045158

[Term]
id: GO:0030067
name: respiratory chain cytochrome b6
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0009055

[Term]
id: GO:0030068
name: lytic viral life cycle
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because more specific terms were created.
is_obsolete: true
consider: GO:0019058
consider: GO:0019077

[Term]
id: GO:0030069
name: lysogeny
namespace: biological_process
def: "The incorporation of a bacteriophage genome into the genome of its bacterial host organism." [ISBN:0781702534]
xref: Wikipedia:Lysogenic_cycle
is_a: GO:0022415 ! viral reproductive process

[Term]
id: GO:0030070
name: insulin processing
namespace: biological_process
def: "The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0016486 ! peptide hormone processing

[Term]
id: GO:0030071
name: regulation of mitotic metaphase/anaphase transition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle." [GOC:mah]
is_a: GO:0007088 ! regulation of mitosis
relationship: regulates GO:0007091 ! mitotic metaphase/anaphase transition

[Term]
id: GO:0030072
name: peptide hormone secretion
namespace: biological_process
def: "The regulated release of a peptide hormone from vesicles or secretory granules." [GOC:mah]
is_a: GO:0002790 ! peptide secretion
is_a: GO:0046879 ! hormone secretion

[Term]
id: GO:0030073
name: insulin secretion
namespace: biological_process
def: "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0030074
name: thylakoid (sensu Proteobacteria)
namespace: cellular_component
def: "OBSOLETE. A thylakoid; as in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mah]
comment: This term was made obsolete because thylakoids are not found in organisms of the Phylum Proteobacteria.
is_obsolete: true
consider: GO:0042716

[Term]
id: GO:0030075
name: plasma membrane-derived thylakoid
namespace: cellular_component
def: "A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
is_a: GO:0009579 ! thylakoid
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0030076
name: light-harvesting complex
namespace: cellular_component
def: "A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center." [GOC:lr]
subset: goslim_pir
subset: gosubset_prok
synonym: "antenna complex" RELATED []
xref: Wikipedia:Light-harvesting_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0030077
name: plasma membrane light-harvesting complex
namespace: cellular_component
def: "A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
is_a: GO:0030076 ! light-harvesting complex
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore

[Term]
id: GO:0030078
name: light-harvesting complex, core complex
namespace: cellular_component
def: "Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria." [GOC:lr]
subset: gosubset_prok
is_a: GO:0030077 ! plasma membrane light-harvesting complex

[Term]
id: GO:0030079
name: light-harvesting complex, peripheral complex
namespace: cellular_component
def: "Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center." [GOC:lr]
subset: gosubset_prok
is_a: GO:0030077 ! plasma membrane light-harvesting complex

[Term]
id: GO:0030080
name: B875 antenna complex
namespace: cellular_component
def: "Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm." [GOC:kd]
subset: gosubset_prok
synonym: "LH1 complex" EXACT []
synonym: "light harvesting complex I" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030078 ! light-harvesting complex, core complex

[Term]
id: GO:0030081
name: B800-820 antenna complex
namespace: cellular_component
def: "Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr]
subset: gosubset_prok
synonym: "LH3 complex" EXACT []
synonym: "light harvesting complex III" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex

[Term]
id: GO:0030082
name: B800-850 antenna complex
namespace: cellular_component
def: "Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr]
subset: gosubset_prok
synonym: "LH2 complex" EXACT []
synonym: "light harvesting complex II" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex

[Term]
id: GO:0030083
name: PSI associated light-harvesting complex I, LHCIa subcomplex
namespace: cellular_component
def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm." [PMID:8825475]
is_a: GO:0009518 ! PSI associated light-harvesting complex I

[Term]
id: GO:0030084
name: PSI associated light-harvesting complex I, LHCIb subcomplex
namespace: cellular_component
def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm." [PMID:8825475]
is_a: GO:0009518 ! PSI associated light-harvesting complex I

[Term]
id: GO:0030085
name: PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex
namespace: cellular_component
def: "A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides." [PMID:8825475]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009656 ! PSII associated light-harvesting complex II, peripheral complex

[Term]
id: GO:0030086
name: PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the 'complex' it refers to contains only one gene product.
is_obsolete: true
replaced_by: GO:0009655

[Term]
id: GO:0030087
name: PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the 'complex' it refers to contains only one gene product.
is_obsolete: true
replaced_by: GO:0009655

[Term]
id: GO:0030088
name: PSII associated light-harvesting complex II, core complex, LHCIId subcomplex
namespace: cellular_component
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because the 'complex' it refers to contains only one gene product.
is_obsolete: true
replaced_by: GO:0009655

[Term]
id: GO:0030089
name: phycobilisome
namespace: cellular_component
def: "Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II." [GOC:jl, http://en.wikipedia.org/wiki/Phycobilisome, PMID:11734882]
subset: gosubset_prok
xref: Wikipedia:Phycobilisome
is_a: GO:0030076 ! light-harvesting complex
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0042651 ! thylakoid membrane

[Term]
id: GO:0030091
name: protein repair
namespace: biological_process
def: "The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0030092
name: regulation of flagellum assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators]
synonym: "regulation of flagella assembly" RELATED [GOC:mah]
synonym: "regulation of flagella biogenesis" RELATED []
synonym: "regulation of flagellum biogenesis" RELATED [GOC:mah]
is_a: GO:0060491 ! regulation of cell projection assembly
relationship: regulates GO:0009296 ! flagellum assembly

[Term]
id: GO:0030093
name: chloroplast photosystem I
namespace: cellular_component
def: "Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. An example of this is found in Arabidopsis thaliana." [GOC:jic, GOC:mtg_sensu]
is_a: GO:0009522 ! photosystem I
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009535 ! chloroplast thylakoid membrane

[Term]
id: GO:0030094
name: plasma membrane-derived photosystem I
namespace: cellular_component
def: "A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. Examples of this complex are found in bacterial species." [GOC:jic, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "plasma membrane photosystem I" EXACT []
is_a: GO:0009522 ! photosystem I
is_a: GO:0044436 ! thylakoid part
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0030075 ! plasma membrane-derived thylakoid

[Term]
id: GO:0030095
name: chloroplast photosystem II
namespace: cellular_component
def: "An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jic, GOC:mtg_sensu]
is_a: GO:0009523 ! photosystem II
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0009535 ! chloroplast thylakoid membrane

[Term]
id: GO:0030096
name: plasma membrane-derived thylakoid photosystem II
namespace: cellular_component
def: "A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jic, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "plasma membrane photosystem II" EXACT []
is_a: GO:0009523 ! photosystem II
is_a: GO:0044436 ! thylakoid part
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0030075 ! plasma membrane-derived thylakoid

[Term]
id: GO:0030097
name: hemopoiesis
namespace: biological_process
def: "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "blood cell biosynthesis" EXACT []
synonym: "blood cell formation" EXACT []
synonym: "haemopoiesis" EXACT []
synonym: "hematopoiesis" EXACT []
xref: Wikipedia:Haematopoiesis
is_a: GO:0048534 ! hemopoietic or lymphoid organ development

[Term]
id: GO:0030098
name: lymphocyte differentiation
namespace: biological_process
alt_id: GO:0046650
def: "The process whereby a relatively unspecialized precursor cell acquires specialized features of B cells, T cells, or natural killer cells." [GOC:go_curators]
synonym: "lymphocyte cell differentiation" EXACT []
synonym: "lymphocytic blood cell differentiation" EXACT []
is_a: GO:0002521 ! leukocyte differentiation
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0030099
name: myeloid cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0030100
name: regulation of endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators]
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0060627 ! regulation of vesicle-mediated transport
relationship: regulates GO:0006897 ! endocytosis

[Term]
id: GO:0030101
name: natural killer cell activation
namespace: biological_process
def: "The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735140]
synonym: "NK cell activation" EXACT []
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0030103
name: vasopressin secretion
namespace: biological_process
def: "The regulated release of vasopressin from secretory granules into the blood." [GOC:mah]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0030104
name: water homeostasis
namespace: biological_process
alt_id: GO:0018987
def: "Any process involved in the maintenance of an internal equilibrium of water within an organism or cell." [GOC:dph, GOC:mah, GOC:tb]
synonym: "osmoregulation" RELATED []
synonym: "regulation of osmotic pressure" EXACT []
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0030105
name: anaphylaxis
namespace: biological_process
def: "OBSOLETE. Extreme immunological sensitivity of the body or tissues to the reintroduction of an antigen. It is a form of anamnestic reaction and is accompanied by pathological changes in tissues or organs due to the release of pharmacologically active substances." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a an abnormal process that is harmful to the organism.
is_obsolete: true
consider: GO:0006955

[Term]
id: GO:0030106
name: MHC class I receptor activity
namespace: molecular_function
def: "OBSOLETE. A major histocompatibility complex class I receptor. These display processed antigens from the endocytosed bacteria. MHC class I proteins can form complexes with processed antigen peptides only if the antigen is synthesized in the same cell. As a consequence, T lymphocytes can only bind to class-I-positive cells that are synthesizing the antigen (e.g. virus-infected cells)." [ISBN:081533642X, ISBN:0879694971]
comment: This term was made obsolete because the definition is ambiguous and contains incorrect information. To update annotations of gene products that act as receptors for MHC class I protein complexes, use the molecular function term 'MHC class I receptor activity ; GO:0032393'; to update annotations of gene products which are components of MHC class I protein complexes, use the cellular component term 'MHC class I protein complex ; GO:0042612'.
synonym: "class I major histocompatibility complex antigen" RELATED []
synonym: "major histocompatibility complex class I receptor" EXACT []
is_obsolete: true
consider: GO:0032393
consider: GO:0042612

[Term]
id: GO:0030107
name: HLA-A specific inhibitory MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]
is_a: GO:0032396 ! inhibitory MHC class I receptor activity

[Term]
id: GO:0030108
name: HLA-A specific activating MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]
is_a: GO:0032397 ! activating MHC class I receptor activity

[Term]
id: GO:0030109
name: HLA-B specific inhibitory MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]
is_a: GO:0032396 ! inhibitory MHC class I receptor activity

[Term]
id: GO:0030110
name: HLA-C specific inhibitory MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]
is_a: GO:0032396 ! inhibitory MHC class I receptor activity

[Term]
id: GO:0030111
name: regulation of Wnt receptor signaling pathway
namespace: biological_process
alt_id: GO:0008590
def: "Any process that modulates the frequency, rate or extent of the activity of the Wnt receptor mediated signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of frizzled signaling pathway" EXACT []
synonym: "regulation of frizzled signalling pathway" EXACT []
synonym: "regulation of Wnt receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0016055 ! Wnt receptor signaling pathway

[Term]
id: GO:0030112
name: glycocalyx
namespace: cellular_component
def: "A viscous, carbohydrate rich layer at the outermost periphery of a cell." [GOC:mlg, ISBN:0815316208]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Glycocalyx
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0030114
name: slime layer
namespace: cellular_component
def: "A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids." [GOC:mlg, http://www.wikipedia.org/Slime_layer]
xref: Wikipedia:Slime_layer
is_a: GO:0030112 ! glycocalyx

[Term]
id: GO:0030115
name: S-layer
namespace: cellular_component
def: "A crystalline protein layer surrounding some bacteria." [GOC:mlg, ISBN:0815108893]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:S-layer
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0030116
name: glial cell line-derived neurotrophic factor receptor binding
namespace: molecular_function
def: "A growth factor that binds to glial cell line-derived neurotrophic factor receptors." [PMID:11476867]
synonym: "glial cell line-derived neurotrophic factor receptor ligand" NARROW []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0030117
name: membrane coat
namespace: cellular_component
def: "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0048475 ! coated membrane

[Term]
id: GO:0030118
name: clathrin coat
namespace: cellular_component
alt_id: GO:0016190
def: "A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes." [GOC:mah, PMID:11252894, PMID:9531549]
synonym: "clathrin cage" EXACT []
xref: NIF_Subcellular:sao879919129
xref: Wikipedia:Clathrin
is_a: GO:0030117 ! membrane coat

[Term]
id: GO:0030119
name: AP-type membrane coat adaptor complex
namespace: cellular_component
def: "Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]
subset: goslim_pir
synonym: "clathrin adaptor" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0030117 ! membrane coat

[Term]
id: GO:0030120
name: vesicle coat
namespace: cellular_component
def: "A membrane coat found on a coated vesicle." [GOC:mah]
xref: NIF_Subcellular:sao1177708494
is_a: GO:0030117 ! membrane coat
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030662 ! coated vesicle membrane

[Term]
id: GO:0030121
name: AP-1 adaptor complex
namespace: cellular_component
def: "An AP-type membrane coat adaptor complex that consists of beta1, gamma1, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network." [GOC:mah, PMID:10611976]
synonym: "HA1" EXACT []
synonym: "HA1 clathrin adaptor" EXACT []
is_a: GO:0030131 ! clathrin adaptor complex
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030130 ! clathrin coat of trans-Golgi network vesicle

[Term]
id: GO:0030122
name: AP-2 adaptor complex
namespace: cellular_component
def: "An AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles." [GOC:mah, PMID:10611976]
synonym: "HA2" EXACT []
synonym: "HA2 clathrin adaptor" EXACT []
is_a: GO:0030131 ! clathrin adaptor complex
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0030128 ! clathrin coat of endocytic vesicle
relationship: part_of GO:0030132 ! clathrin coat of coated pit

[Term]
id: GO:0030123
name: AP-3 adaptor complex
namespace: cellular_component
def: "An AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes; it is not clear whether AP-3 forms clathrin coats in vivo." [GOC:mah, PMID:10611976]
is_a: GO:0030119 ! AP-type membrane coat adaptor complex

[Term]
id: GO:0030124
name: AP-4 adaptor complex
namespace: cellular_component
def: "An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo." [GOC:mah, PMID:10611976]
is_a: GO:0030119 ! AP-type membrane coat adaptor complex

[Term]
id: GO:0030125
name: clathrin vesicle coat
namespace: cellular_component
def: "A clathrin coat found on a vesicle." [GOC:mah]
is_a: GO:0030118 ! clathrin coat
is_a: GO:0030120 ! vesicle coat
relationship: part_of GO:0030665 ! clathrin coated vesicle membrane

[Term]
id: GO:0030126
name: COPI vesicle coat
namespace: cellular_component
alt_id: GO:0017167
def: "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]
synonym: "coatomer" EXACT []
is_a: GO:0030120 ! vesicle coat
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0030663 ! COPI coated vesicle membrane

[Term]
id: GO:0030127
name: COPII vesicle coat
namespace: cellular_component
def: "One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]
is_a: GO:0030120 ! vesicle coat
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0012507 ! ER to Golgi transport vesicle membrane

[Term]
id: GO:0030128
name: clathrin coat of endocytic vesicle
namespace: cellular_component
def: "A clathrin coat found on an endocytic vesicle." [GOC:mah]
synonym: "clathrin coat of endocytotic vesicle" EXACT []
is_a: GO:0030125 ! clathrin vesicle coat
relationship: part_of GO:0030669 ! clathrin-coated endocytic vesicle membrane

[Term]
id: GO:0030129
name: clathrin coat of synaptic vesicle
namespace: cellular_component
def: "A clathrin coat found on a synaptic vesicle." [GOC:mah]
is_a: GO:0030125 ! clathrin vesicle coat
relationship: part_of GO:0030672 ! synaptic vesicle membrane

[Term]
id: GO:0030130
name: clathrin coat of trans-Golgi network vesicle
namespace: cellular_component
def: "A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah]
synonym: "clathrin coat of TGN vesicle" EXACT []
is_a: GO:0030125 ! clathrin vesicle coat
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane

[Term]
id: GO:0030131
name: clathrin adaptor complex
namespace: cellular_component
def: "A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah]
is_a: GO:0030119 ! AP-type membrane coat adaptor complex
relationship: part_of GO:0030118 ! clathrin coat

[Term]
id: GO:0030132
name: clathrin coat of coated pit
namespace: cellular_component
def: "The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]
is_a: GO:0030118 ! clathrin coat
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005905 ! coated pit

[Term]
id: GO:0030133
name: transport vesicle
namespace: cellular_component
def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, or to destinations within or outside the cell." [GOC:mah]
comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'.
synonym: "Golgi to vacuole transport vesicle" NARROW []
synonym: "Golgi-vacuole transport vesicle" NARROW []
synonym: "secretory vesicle" BROAD []
xref: NIF_Subcellular:sao885490876
is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0030134
name: ER to Golgi transport vesicle
namespace: cellular_component
alt_id: GO:0030138
def: "A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]
synonym: "COPII vesicle" RELATED []
synonym: "COPII-coated vesicle" EXACT []
synonym: "endoplasmic reticulum to Golgi transport vesicle" EXACT []
synonym: "endoplasmic reticulum-Golgi transport vesicle" EXACT []
synonym: "ER-Golgi transport vesicle" EXACT []
is_a: GO:0030133 ! transport vesicle
is_a: GO:0030135 ! coated vesicle

[Term]
id: GO:0030135
name: coated vesicle
namespace: cellular_component
alt_id: GO:0005909
def: "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194]
xref: NIF_Subcellular:sao1985096626
is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0030136
name: clathrin-coated vesicle
namespace: cellular_component
def: "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]
xref: NIF_Subcellular:sao148845161
is_a: GO:0030135 ! coated vesicle

[Term]
id: GO:0030137
name: COPI-coated vesicle
namespace: cellular_component
def: "A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport." [GOC:mah, PMID:11252894]
synonym: "coatomer" RELATED []
is_a: GO:0005798 ! Golgi-associated vesicle
is_a: GO:0030135 ! coated vesicle

[Term]
id: GO:0030139
name: endocytic vesicle
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators]
subset: gosubset_prok
synonym: "endocytotic transport vesicle" EXACT []
synonym: "endocytotic vesicle" EXACT []
xref: NIF_Subcellular:sao1362520468
is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0030140
name: trans-Golgi network transport vesicle
namespace: cellular_component
def: "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah]
synonym: "TGN transport vesicle" EXACT []
is_a: GO:0005798 ! Golgi-associated vesicle
is_a: GO:0030133 ! transport vesicle
is_a: GO:0030136 ! clathrin-coated vesicle

[Term]
id: GO:0030141
name: secretory granule
namespace: cellular_component
def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198596732]
comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'.
synonym: "secretory vesicle" BROAD []
is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0030142
name: Golgi to ER transport vesicle
namespace: cellular_component
def: "A vesicle that mediates transport from the Golgi to the endoplasmic reticulum." [GOC:mah]
synonym: "Golgi to endoplasmic reticulum transport vesicle" EXACT []
synonym: "Golgi-endoplasmic reticulum transport vesicle" EXACT []
synonym: "Golgi-ER transport vesicle" EXACT []
is_a: GO:0030133 ! transport vesicle
is_a: GO:0030137 ! COPI-coated vesicle

[Term]
id: GO:0030143
name: inter-Golgi transport vesicle
namespace: cellular_component
alt_id: GO:0005807
def: "A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack)." [GOC:mah]
xref: NIF_Subcellular:sao1382918459
is_a: GO:0030133 ! transport vesicle
is_a: GO:0030137 ! COPI-coated vesicle

[Term]
id: GO:0030144
name: alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]
synonym: "alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155]
synonym: "GnTV activity" EXACT [EC:2.4.1.155]
synonym: "N-acetylglucosaminyltransferase V activity" RELATED [EC:2.4.1.155]
synonym: "UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.155]
synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta-1,6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155]
synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155]
synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta-1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155]
synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155]
xref: EC:2.4.1.155
xref: MetaCyc:2.4.1.155-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0030145
name: manganese ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai]
subset: gosubset_prok
synonym: "manganese binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0030146
name: diuresis
namespace: biological_process
alt_id: GO:0003076
def: "The process of renal water excretion." [GOC:mah, GOC:mtg_cardio, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "positive regulation of renal water excretion" EXACT []
synonym: "renal water excretion" BROAD []
xref: Wikipedia:Diuresis
is_a: GO:0003014 ! renal system process
is_a: GO:0007588 ! excretion
is_a: GO:0007589 ! body fluid secretion
relationship: part_of GO:0003091 ! renal water homeostasis

[Term]
id: GO:0030147
name: natriuresis
namespace: biological_process
def: "The process of renal sodium excretion." [GOC:mtg_cardio, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: Wikipedia:Natriuresis
is_a: GO:0003014 ! renal system process
is_a: GO:0007588 ! excretion
is_a: GO:0050801 ! ion homeostasis

[Term]
id: GO:0030148
name: sphingolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sphingolipid anabolism" EXACT []
synonym: "sphingolipid biosynthesis" EXACT []
synonym: "sphingolipid formation" EXACT []
synonym: "sphingolipid synthesis" EXACT []
xref: MetaCyc:PWY-5129
is_a: GO:0006665 ! sphingolipid metabolic process
is_a: GO:0046467 ! membrane lipid biosynthetic process

[Term]
id: GO:0030149
name: sphingolipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sphingolipid breakdown" EXACT []
synonym: "sphingolipid catabolism" EXACT []
synonym: "sphingolipid degradation" EXACT []
is_a: GO:0006665 ! sphingolipid metabolic process
is_a: GO:0046466 ! membrane lipid catabolic process

[Term]
id: GO:0030150
name: protein import into mitochondrial matrix
namespace: biological_process
def: "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363]
synonym: "mitochondrial matrix protein import" EXACT []
synonym: "mitochondrial translocation" BROAD []
synonym: "protein transport into mitochondrial matrix" EXACT []
is_a: GO:0006626 ! protein targeting to mitochondrion
is_a: GO:0065002 ! intracellular protein transmembrane transport

[Term]
id: GO:0030151
name: molybdenum ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with molybdenum (Mo) ions." [GOC:ai]
subset: gosubset_prok
synonym: "molybdenum binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0030152
name: bacteriocin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "bacteriocin anabolism" EXACT []
synonym: "bacteriocin biosynthesis" EXACT []
synonym: "bacteriocin formation" EXACT []
synonym: "bacteriocin synthesis" EXACT []
is_a: GO:0009403 ! toxin biosynthetic process
is_a: GO:0030651 ! peptide antibiotic biosynthetic process
is_a: GO:0046224 ! bacteriocin metabolic process

[Term]
id: GO:0030153
name: bacteriocin immunity
namespace: biological_process
def: "A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0009404 ! toxin metabolic process

[Term]
id: GO:0030154
name: cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_generic
subset: goslim_goa
subset: goslim_plant
subset: gosubset_prok
xref: Wikipedia:Cellular_differentiation
is_a: GO:0048869 ! cellular developmental process

[Term]
id: GO:0030155
name: regulation of cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah]
subset: gosubset_prok
synonym: "cell adhesion receptor regulator activity" RELATED []
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0007155 ! cell adhesion

[Term]
id: GO:0030156
name: benzodiazepine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the peripheral benzodiazepine receptor (PBR)." [GOC:ceb, GOC:mah, PMID:9915832]
synonym: "benzodiazepine receptor ligand" NARROW []
synonym: "diazepam binding inhibitor activity" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0030157
name: pancreatic juice secretion
namespace: biological_process
def: "The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0030158
name: protein xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate." [EC:2.4.2.26]
synonym: "peptide O-xylosyltransferase activity" EXACT []
synonym: "UDP-D-xylose:core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26]
synonym: "UDP-D-xylose:core protein xylosyltransferase activity" EXACT [EC:2.4.2.26]
synonym: "UDP-D-xylose:protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26]
synonym: "UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26]
synonym: "UDP-xylose-core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26]
synonym: "uridine diphosphoxylose-core protein beta-xylosyltransferase activity" EXACT [EC:2.4.2.26]
synonym: "uridine diphosphoxylose-protein xylosyltransferase activity" EXACT [EC:2.4.2.26]
xref: EC:2.4.2.26
xref: MetaCyc:2.4.2.26-RXN
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0030159
name: receptor signaling complex scaffold activity
namespace: molecular_function
def: "Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah]
synonym: "receptor signaling complex scaffold protein activity" EXACT []
synonym: "receptor signalling complex scaffold activity" EXACT []
is_a: GO:0032947 ! protein complex scaffold

[Term]
id: GO:0030160
name: GKAP/Homer scaffold activity
namespace: molecular_function
def: "Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses." [PMID:10506216]
synonym: "GKAP/Homer scaffold protein" NARROW []
synonym: "postsynaptic density scaffold protein" NARROW []
is_a: GO:0030159 ! receptor signaling complex scaffold activity

[Term]
id: GO:0030161
name: calpain inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the enzyme calpain, which catalyzes of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue." [GOC:ai]
comment: This term was made obsolete because it represents a regulator of a non-existent molecular function.
is_obsolete: true
replaced_by: GO:0010859

[Term]
id: GO:0030162
name: regulation of proteolysis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of peptidolysis" EXACT []
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: regulates GO:0006508 ! proteolysis

[Term]
id: GO:0030163
name: protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]
subset: goslim_candida
subset: goslim_pombe
subset: gosubset_prok
synonym: "pheromone catabolic process" RELATED []
synonym: "pheromone catabolism" RELATED []
synonym: "protein breakdown" EXACT []
synonym: "protein catabolism" EXACT []
synonym: "protein degradation" EXACT []
xref: Wikipedia:Protein_catabolism
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0019538 ! protein metabolic process

[Term]
id: GO:0030164
name: protein denaturation
namespace: biological_process
def: "Structural change in proteins which destroys the native, active configuration without rupture of peptide bonds." [GOC:kd, ISBN:3110145359]
subset: gosubset_prok
xref: Wikipedia:Denaturation#Protein_denaturation
is_a: GO:0044257 ! cellular protein catabolic process

[Term]
id: GO:0030165
name: PDZ domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595]
synonym: "DHR-domain binding" EXACT []
synonym: "GLGF-domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0030166
name: proteoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "proteoglycan anabolism" EXACT []
synonym: "proteoglycan biosynthesis" EXACT []
synonym: "proteoglycan formation" EXACT []
synonym: "proteoglycan synthesis" EXACT []
is_a: GO:0006029 ! proteoglycan metabolic process
is_a: GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0030167
name: proteoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "proteoglycan breakdown" EXACT []
synonym: "proteoglycan catabolism" EXACT []
synonym: "proteoglycan degradation" EXACT []
is_a: GO:0006029 ! proteoglycan metabolic process
is_a: GO:0009057 ! macromolecule catabolic process

[Term]
id: GO:0030168
name: platelet activation
namespace: biological_process
def: "A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug." [http://www.graylab.ac.uk/omd/]
xref: Reactome:448714 "Platelet Activation"
xref: Reactome:469836 "Platelet Activation"
xref: Reactome:487530 "Platelet Activation"
xref: Reactome:507487 "Platelet Activation"
xref: Reactome:517472 "Platelet Activation"
xref: Reactome:526342 "Platelet Activation"
xref: Reactome:531174 "Platelet Activation"
xref: Reactome:536768 "Platelet Activation"
xref: Reactome:542522 "Platelet Activation"
xref: Reactome:547845 "Platelet Activation"
xref: Reactome:552417 "Platelet Activation"
xref: Reactome:558026 "Platelet Activation"
xref: Reactome:568676 "Platelet Activation"
xref: Reactome:581879 "Platelet Activation"
xref: Reactome:585933 "Platelet Activation"
xref: Reactome:592654 "Platelet Activation"
xref: Reactome:595508 "Platelet Activation"
xref: Reactome:597407 "Platelet Activation"
xref: Reactome:599751 "Platelet Activation"
xref: Reactome:600650 "Platelet Activation"
xref: Reactome:76002 "Platelet Activation"
is_a: GO:0001775 ! cell activation
relationship: part_of GO:0007596 ! blood coagulation

[Term]
id: GO:0030169
name: low-density lipoprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with low-density lipoprotein, one of the classes of lipoproteins found in blood plasma in many animals (data normally relate to humans)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "LDL binding" EXACT []
is_a: GO:0008034 ! lipoprotein binding

[Term]
id: GO:0030170
name: pyridoxal phosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0048037 ! cofactor binding
is_a: GO:0070279 ! vitamin B6 binding

[Term]
id: GO:0030171
name: voltage-gated proton channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of a proton by a voltage-gated channel." [ISBN:10615049]
synonym: "voltage gated proton channel activity" EXACT []
synonym: "voltage-dependent proton channel activity" EXACT []
is_a: GO:0022843 ! voltage-gated cation channel activity

[Term]
id: GO:0030172
name: troponin C binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0030173
name: integral to Golgi membrane
namespace: cellular_component
def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the Golgi complex membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators]
synonym: "Golgi integral membrane protein" RELATED []
is_a: GO:0031228 ! intrinsic to Golgi membrane
is_a: GO:0031301 ! integral to organelle membrane

[Term]
id: GO:0030174
name: regulation of DNA replication initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of initiation of DNA replication; the process by which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah]
subset: gosubset_prok
synonym: "DNA replication licencing" EXACT []
synonym: "DNA replication licensing" EXACT []
is_a: GO:0006275 ! regulation of DNA replication
relationship: regulates GO:0006270 ! DNA replication initiation

[Term]
id: GO:0030175
name: filopodium
namespace: cellular_component
alt_id: GO:0030028
def: "Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward." [GOC:mah, ISBN:0815316194]
subset: goslim_pir
synonym: "microspike" EXACT []
xref: NIF_Subcellular:sao-1046371754
xref: Wikipedia:Filopodia
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0030176
name: integral to endoplasmic reticulum membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
synonym: "ER integral membrane protein" EXACT []
synonym: "integral to ER membrane" EXACT []
is_a: GO:0031227 ! intrinsic to endoplasmic reticulum membrane
is_a: GO:0031301 ! integral to organelle membrane

[Term]
id: GO:0030177
name: positive regulation of Wnt receptor signaling pathway
namespace: biological_process
alt_id: GO:0045811
def: "Any process that activates or increases the frequency, rate or extent of Wnt receptor signaling pathway activity." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of frizzled signaling pathway" NARROW []
synonym: "activation of Wnt receptor signaling pathway" NARROW []
synonym: "positive regulation of frizzled signaling pathway" EXACT []
synonym: "positive regulation of frizzled signalling pathway" EXACT []
synonym: "positive regulation of Wnt receptor signalling pathway" EXACT []
synonym: "stimulation of frizzled signaling pathway" NARROW []
synonym: "stimulation of Wnt receptor signaling pathway" NARROW []
synonym: "up regulation of frizzled signaling pathway" EXACT []
synonym: "up regulation of Wnt receptor signaling pathway" EXACT []
synonym: "up-regulation of frizzled signaling pathway" EXACT []
synonym: "up-regulation of Wnt receptor signaling pathway" EXACT []
synonym: "upregulation of frizzled signaling pathway" EXACT []
synonym: "upregulation of Wnt receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway
relationship: positively_regulates GO:0016055 ! Wnt receptor signaling pathway

[Term]
id: GO:0030178
name: negative regulation of Wnt receptor signaling pathway
namespace: biological_process
alt_id: GO:0045810
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Wnt receptor signaling pathway activity." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of frizzled signaling pathway" EXACT []
synonym: "down regulation of Wnt receptor signaling pathway" EXACT []
synonym: "down-regulation of frizzled signaling pathway" EXACT []
synonym: "down-regulation of Wnt receptor signaling pathway" EXACT []
synonym: "downregulation of frizzled signaling pathway" EXACT []
synonym: "downregulation of Wnt receptor signaling pathway" EXACT []
synonym: "inhibition of frizzled signaling pathway" NARROW []
synonym: "inhibition of Wnt receptor signaling pathway" NARROW []
synonym: "negative regulation of frizzled signaling pathway" EXACT []
synonym: "negative regulation of frizzled signalling pathway" EXACT []
synonym: "negative regulation of Wnt receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway
relationship: negatively_regulates GO:0016055 ! Wnt receptor signaling pathway

[Term]
id: GO:0030180
name: solute:solute exchange
namespace: biological_process
def: "OBSOLETE. Exchange diffusion of two solutes between the inside and outside of a cell or subcellular compartment, in which movement of one solute down a concentration gradient drives movement of the other solute in the opposite direction." [GOC:mah]
comment: This term was made obsolete because it represents a molecular function.
is_obsolete: true
replaced_by: GO:0006810
replaced_by: GO:0015300

[Term]
id: GO:0030181
name: sodium:calcium exchange
namespace: biological_process
def: "OBSOLETE. Exchange diffusion sodium and calcium ions in which influx of sodium ions to the cytosol drives the efflux of calcium ions from the cell." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a function rather than a process.
is_obsolete: true
replaced_by: GO:0006814
replaced_by: GO:0006816
consider: GO:0005432

[Term]
id: GO:0030182
name: neuron differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0030183
name: B cell differentiation
namespace: biological_process
alt_id: GO:0042115
def: "The process whereby a precursor cell type acquires the specialized features of a B cell." [GO_REF:0000022, GOC:mah, GOC:mtg_15nov05]
comment: This term was improved by GO_REF:0000022. It was moved.
synonym: "B lymphocyte differentiation" EXACT []
synonym: "B-cell differentiation" EXACT []
synonym: "B-lymphocyte differentiation" EXACT []
is_a: GO:0030098 ! lymphocyte differentiation
is_a: GO:0042113 ! B cell activation

[Term]
id: GO:0030184
name: nitric oxide transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of nitric oxide, nitrogen monoxide, from one side of a membrane to the other." [GOC:mah]
subset: gosubset_prok
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0030185
name: nitric oxide transport
namespace: biological_process
def: "The directed movement of nitric oxide, nitrogen monoxide, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0006810 ! transport

[Term]
id: GO:0030186
name: melatonin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "melatonin metabolism" EXACT []
is_a: GO:0006586 ! indolalkylamine metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process

[Term]
id: GO:0030187
name: melatonin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "melatonin anabolism" EXACT []
synonym: "melatonin biosynthesis" EXACT []
synonym: "melatonin formation" EXACT []
synonym: "melatonin synthesis" EXACT []
is_a: GO:0030186 ! melatonin metabolic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0046219 ! indolalkylamine biosynthetic process

[Term]
id: GO:0030188
name: chaperone regulator activity
namespace: molecular_function
def: "OBSOLETE. Modulates the activity of a molecular chaperone." [GOC:mah]
comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'.
is_obsolete: true
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0030189
name: chaperone activator activity
namespace: molecular_function
def: "OBSOLETE. Increases the activity of a molecular chaperone." [GOC:mah]
comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'.
subset: gosubset_prok
is_obsolete: true
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0030190
name: chaperone inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of a molecular chaperone." [GOC:mah]
comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'.
is_obsolete: true
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0030191
name: Hsp70/Hsc70 protein inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70/Hsc70 protein activity'.
is_obsolete: true
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0030192
name: Hsp70/Hsc70 protein regulator activity
namespace: molecular_function
def: "OBSOLETE. Modulates the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70/Hsc70 protein activity'.
subset: gosubset_prok
is_obsolete: true
consider: GO:0006457
consider: GO:0051082
consider: GO:0051787

[Term]
id: GO:0030193
name: regulation of blood coagulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of blood coagulation." [GOC:mah]
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0050818 ! regulation of coagulation
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:0007596 ! blood coagulation

[Term]
id: GO:0030194
name: positive regulation of blood coagulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of blood coagulation." [GOC:mah]
synonym: "activation of blood coagulation" NARROW []
synonym: "stimulation of blood coagulation" NARROW []
synonym: "up regulation of blood coagulation" EXACT []
synonym: "up-regulation of blood coagulation" EXACT []
synonym: "upregulation of blood coagulation" EXACT []
is_a: GO:0030193 ! regulation of blood coagulation
is_a: GO:0050820 ! positive regulation of coagulation
relationship: positively_regulates GO:0007596 ! blood coagulation

[Term]
id: GO:0030195
name: negative regulation of blood coagulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation." [GOC:mah]
synonym: "down regulation of blood coagulation" EXACT []
synonym: "down-regulation of blood coagulation" EXACT []
synonym: "downregulation of blood coagulation" EXACT []
synonym: "inhibition of blood coagulation" NARROW []
is_a: GO:0030193 ! regulation of blood coagulation
is_a: GO:0050819 ! negative regulation of coagulation
relationship: negatively_regulates GO:0007596 ! blood coagulation

[Term]
id: GO:0030196
name: cyanide hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: formamide = cyanide + H2O." [EC:4.2.1.66]
synonym: "formamide dehydratase activity" EXACT [EC:4.2.1.66]
synonym: "formamide hydro-lyase (cyanide-forming)" EXACT [EC:4.2.1.66]
synonym: "formamide hydro-lyase activity" EXACT [EC:4.2.1.66]
xref: EC:4.2.1.66
xref: MetaCyc:CYANIDE-HYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0030197
name: extracellular matrix constituent, lubricant activity
namespace: molecular_function
def: "Functions as a lubricant for an extracellular matrix, such as a mucous membrane." [GOC:mah]
is_a: GO:0005201 ! extracellular matrix structural constituent

[Term]
id: GO:0030198
name: extracellular matrix organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]
subset: gosubset_prok
synonym: "extracellular matrix organisation" EXACT [GOC:curators]
synonym: "extracellular matrix organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0043062 ! extracellular structure organization

[Term]
id: GO:0030199
name: collagen fibril organization
namespace: biological_process
def: "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix." [GOC:mah, ISBN:0815316194]
synonym: "collagen fibril organisation" EXACT [GOC:curators]
synonym: "fibrillar collagen organization" EXACT [GOC:mah]
is_a: GO:0030198 ! extracellular matrix organization

[Term]
id: GO:0030200
name: heparan sulfate proteoglycan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha1->4 linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "heparan sulfate proteoglycan breakdown" EXACT []
synonym: "heparan sulfate proteoglycan catabolism" EXACT []
synonym: "heparan sulfate proteoglycan degradation" EXACT []
synonym: "heparan sulphate proteoglycan catabolic process" EXACT []
synonym: "heparan sulphate proteoglycan catabolism" EXACT []
synonym: "heparin proteoglycan catabolic process" RELATED []
is_a: GO:0030167 ! proteoglycan catabolic process
is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0030201
name: heparan sulfate proteoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha1->4 linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "heparan sulfate proteoglycan metabolism" EXACT []
synonym: "heparan sulphate proteoglycan metabolic process" EXACT []
synonym: "heparan sulphate proteoglycan metabolism" EXACT []
synonym: "heparin proteoglycan metabolic process" RELATED []
is_a: GO:0006029 ! proteoglycan metabolic process
is_a: GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0030202
name: heparin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "heparan sulfate metabolic process" RELATED []
synonym: "heparin metabolism" EXACT []
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0030203
name: glycosaminoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties." [ISBN:0192800981]
subset: gosubset_prok
synonym: "glycosaminoglycan metabolism" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process

[Term]
id: GO:0030204
name: chondroitin sulfate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "chondroitin sulfate metabolism" EXACT []
synonym: "chondroitin sulphate metabolic process" EXACT []
synonym: "chondroitin sulphate metabolism" EXACT []
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process
relationship: part_of GO:0050654 ! chondroitin sulfate proteoglycan metabolic process

[Term]
id: GO:0030205
name: dermatan sulfate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "chondroitin sulfate B metabolic process" EXACT []
synonym: "chondroitin sulfate B metabolism" EXACT []
synonym: "dermatan sulfate metabolism" EXACT []
synonym: "dermatan sulphate metabolic process" EXACT []
synonym: "dermatan sulphate metabolism" EXACT []
is_a: GO:0030204 ! chondroitin sulfate metabolic process
relationship: part_of GO:0050655 ! dermatan sulfate proteoglycan metabolic process

[Term]
id: GO:0030206
name: chondroitin sulfate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "chondroitin sulfate anabolism" EXACT []
synonym: "chondroitin sulfate biosynthesis" EXACT []
synonym: "chondroitin sulfate formation" EXACT []
synonym: "chondroitin sulfate synthesis" EXACT []
synonym: "chondroitin sulphate biosynthesis" EXACT []
synonym: "chondroitin sulphate biosynthetic process" EXACT []
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0030204 ! chondroitin sulfate metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
relationship: part_of GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process

[Term]
id: GO:0030207
name: chondroitin sulfate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "chondroitin sulfate breakdown" EXACT []
synonym: "chondroitin sulfate catabolism" EXACT []
synonym: "chondroitin sulfate degradation" EXACT []
synonym: "chondroitin sulphate catabolic process" EXACT []
synonym: "chondroitin sulphate catabolism" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0030204 ! chondroitin sulfate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0030208
name: dermatan sulfate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "chondroitin sulfate B biosynthesis" EXACT []
synonym: "chondroitin sulfate B biosynthetic process" EXACT []
synonym: "dermatan sulfate anabolism" EXACT []
synonym: "dermatan sulfate biosynthesis" EXACT []
synonym: "dermatan sulfate formation" EXACT []
synonym: "dermatan sulfate synthesis" EXACT []
synonym: "dermatan sulphate biosynthesis" EXACT []
synonym: "dermatan sulphate biosynthetic process" EXACT []
is_a: GO:0030205 ! dermatan sulfate metabolic process
is_a: GO:0030206 ! chondroitin sulfate biosynthetic process
relationship: part_of GO:0050651 ! dermatan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0030209
name: dermatan sulfate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "chondroitin sulfate B catabolic process" EXACT []
synonym: "chondroitin sulfate B catabolism" EXACT []
synonym: "dermatan sulfate breakdown" EXACT []
synonym: "dermatan sulfate catabolism" EXACT []
synonym: "dermatan sulfate degradation" EXACT []
synonym: "dermatan sulphate catabolic process" EXACT []
synonym: "dermatan sulphate catabolism" EXACT []
is_a: GO:0030205 ! dermatan sulfate metabolic process
is_a: GO:0030207 ! chondroitin sulfate catabolic process

[Term]
id: GO:0030210
name: heparin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "heparan sulfate biosynthetic process" RELATED []
synonym: "heparin anabolism" EXACT []
synonym: "heparin biosynthesis" EXACT []
synonym: "heparin formation" EXACT []
synonym: "heparin synthesis" EXACT []
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0030202 ! heparin metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0030211
name: heparin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha1->4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "heparan sulfate catabolic process" RELATED []
synonym: "heparin breakdown" EXACT []
synonym: "heparin catabolism" EXACT []
synonym: "heparin degradation" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0030202 ! heparin metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0030212
name: hyaluronan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "hyaluronan metabolism" EXACT []
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0030213
name: hyaluronan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "hyaluronan anabolism" EXACT []
synonym: "hyaluronan biosynthesis" EXACT []
synonym: "hyaluronan formation" EXACT []
synonym: "hyaluronan synthesis" EXACT []
is_a: GO:0006024 ! glycosaminoglycan biosynthetic process
is_a: GO:0030212 ! hyaluronan metabolic process

[Term]
id: GO:0030214
name: hyaluronan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "hyaluronan breakdown" EXACT []
synonym: "hyaluronan catabolism" EXACT []
synonym: "hyaluronan degradation" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0030212 ! hyaluronan metabolic process

[Term]
id: GO:0030215
name: semaphorin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with semaphorin receptors." [GOC:ceb, PMID:12001990]
synonym: "plexin binding" NARROW []
synonym: "plexin ligand" NARROW []
synonym: "semaphorin receptor ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0030216
name: keratinocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a keratinocyte." [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb]
synonym: "keratinocyte cell differentiation" EXACT []
is_a: GO:0009913 ! epidermal cell differentiation
is_a: GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0030217
name: T cell differentiation
namespace: biological_process
alt_id: GO:0042112
alt_id: GO:0046652
def: "The process by which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." [GO_REF:0000022, GOC:jic, GOC:mah, GOC:mtg_15nov05]
comment: This term was improved by GO_REF:0000022. It was moved. Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant.
synonym: "T cell development" EXACT []
synonym: "T lymphocyte differentiation" EXACT []
synonym: "T-cell development" EXACT []
synonym: "T-cell differentiation" EXACT []
synonym: "T-lymphocyte differentiation" EXACT []
is_a: GO:0030098 ! lymphocyte differentiation
is_a: GO:0042110 ! T cell activation

[Term]
id: GO:0030218
name: erythrocyte differentiation
namespace: biological_process
def: "The process by which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah]
synonym: "erythrocyte cell differentiation" EXACT []
synonym: "erythropoiesis" EXACT [GOC:adiehl, GOC:dph]
synonym: "RBC differentiation" EXACT [CL:0000232]
synonym: "red blood cell differentiation" EXACT [CL:0000232]
xref: Wikipedia:Erythropoiesis
is_a: GO:0030099 ! myeloid cell differentiation
relationship: part_of GO:0034101 ! erythrocyte homeostasis

[Term]
id: GO:0030219
name: megakaryocyte differentiation
namespace: biological_process
def: "The process by which a myeloid precursor cell acquires specializes features of a megakaryocyte." [GOC:mah]
synonym: "megakaryocyte cell differentiation" EXACT []
is_a: GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0030220
name: platelet formation
namespace: biological_process
def: "The process by which platelets bud from long processes extended by megakaryocytes." [GOC:mah, ISBN:0815316194]
synonym: "platelet extrusion" EXACT systematic_synonym [GOC:curators]
is_a: GO:0030099 ! myeloid cell differentiation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0030221
name: basophil differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell." [GOC:jic, GOC:mah]
synonym: "basophil cell differentiation" EXACT []
is_a: GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030222
name: eosinophil differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil." [GOC:mah]
synonym: "eosinophil cell differentiation" EXACT []
is_a: GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030223
name: neutrophil differentiation
namespace: biological_process
def: "The process by which a myeloid precursor cell acquires the specialized features of a neutrophil." [GOC:mah]
synonym: "neutrophil cell differentiation" EXACT []
is_a: GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030224
name: monocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte." [GOC:mah]
synonym: "monocyte cell differentiation" EXACT []
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0030225
name: macrophage differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized monocyte acquires the specialized features of a macrophage." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "macrophage cell differentiation" EXACT []
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0030226
name: apolipoprotein receptor activity
namespace: molecular_function
def: "Combining with an apolipoprotein, the protein component of a lipoprotein, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0004872 ! receptor activity
is_a: GO:0034185 ! apolipoprotein binding

[Term]
id: GO:0030227
name: apolipoprotein E receptor activity
namespace: molecular_function
def: "OBSOLETE. Combining with apolipoprotein E to initiate a change in cell activity." [GOC:mah]
comment: This term was made obsolete because no known receptor binds apolipoprotein E; instead, receptors bind holo-lipoprotein E (apolipoprotein E + bound lipid).
synonym: "ApoE receptor" EXACT []
is_obsolete: true
replaced_by: GO:0030229

[Term]
id: GO:0030228
name: lipoprotein receptor activity
namespace: molecular_function
def: "Combining with a lipoprotein to initiate a change in cell activity. A lipoprotein is any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids; the lipid may be triglyceride, cholesterol, or phospholipid, or a combination of these." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0004888 ! transmembrane receptor activity
is_a: GO:0008034 ! lipoprotein binding

[Term]
id: GO:0030229
name: very-low-density lipoprotein receptor activity
namespace: molecular_function
def: "Combining with a very-low-density lipoprotein to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "apolipoprotein E receptor activity" RELATED [GOC:rl]
synonym: "VLDL receptor" EXACT []
xref: Wikipedia:VLDL_receptor
is_a: GO:0030228 ! lipoprotein receptor activity
is_a: GO:0034189 ! very-low-density lipoprotein binding

[Term]
id: GO:0030232
name: insulin control element activator complex
namespace: cellular_component
def: "Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription." [PMID:7935390]
synonym: "ICE activator complex" EXACT []
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0030233
name: deoxynucleotide transmembrane transporter activity
namespace: molecular_function
def: "Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP." [PMID:11226231]
is_a: GO:0015215 ! nucleotide transmembrane transporter activity

[Term]
id: GO:0030234
name: enzyme regulator activity
namespace: molecular_function
def: "Modulates the activity of an enzyme." [GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "catalytic regulator activity" EXACT [GOC:dph]
synonym: "enzyme modulator" EXACT []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0030235
name: nitric-oxide synthase regulator activity
namespace: molecular_function
def: "Modulates the activity of nitric oxide synthase." [GOC:mah]
comment: See also 'regulation of nitric-oxide synthase activity ; GO:0050999'.
synonym: "nitric oxide synthase regulator activity" EXACT []
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0030237
name: female sex determination
namespace: biological_process
def: "The specification of female sex of an individual organism." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0030238
name: male sex determination
namespace: biological_process
def: "The specification of male sex of an individual organism." [GOC:mah]
is_a: GO:0007530 ! sex determination
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0030239
name: myofibril assembly
namespace: biological_process
def: "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
is_a: GO:0031032 ! actomyosin structure organization
relationship: part_of GO:0055002 ! striated muscle cell development

[Term]
id: GO:0030240
name: skeletal muscle thin filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle]
is_a: GO:0007015 ! actin filament organization
relationship: part_of GO:0014866 ! skeletal myofibril assembly

[Term]
id: GO:0030241
name: skeletal muscle thick filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle]
is_a: GO:0031034 ! myosin filament assembly
relationship: part_of GO:0014866 ! skeletal myofibril assembly

[Term]
id: GO:0030242
name: peroxisome degradation
namespace: biological_process
def: "The process by which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions." [PMID:10547367]
synonym: "pexophagy" EXACT []
is_a: GO:0006914 ! autophagy
is_a: GO:0007031 ! peroxisome organization

[Term]
id: GO:0030243
name: cellulose metabolic process
namespace: biological_process
alt_id: GO:0016177
def: "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cellulose metabolism" EXACT []
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:0030244
name: cellulose biosynthetic process
namespace: biological_process
alt_id: GO:0016178
def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cellulose anabolism" EXACT []
synonym: "cellulose biosynthesis" EXACT []
synonym: "cellulose formation" EXACT []
synonym: "cellulose synthesis" EXACT []
xref: MetaCyc:PWY-1001
is_a: GO:0009250 ! glucan biosynthetic process
is_a: GO:0030243 ! cellulose metabolic process

[Term]
id: GO:0030245
name: cellulose catabolic process
namespace: biological_process
alt_id: GO:0016179
def: "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cellulose breakdown" EXACT []
synonym: "cellulose catabolism" EXACT []
synonym: "cellulose degradation" EXACT []
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0030243 ! cellulose metabolic process

[Term]
id: GO:0030246
name: carbohydrate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah]
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "selectin" RELATED []
is_a: GO:0005488 ! binding

[Term]
id: GO:0030247
name: polysaccharide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any polysaccharide, a polymer of more than 20 monosaccharide residues joined by glycosidic linkages." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001871 ! pattern binding
is_a: GO:0030246 ! carbohydrate binding

[Term]
id: GO:0030248
name: cellulose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cellulose." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0030249
name: guanylate cyclase regulator activity
namespace: molecular_function
def: "Modulates the activity of guanylate cyclase." [GOC:mah]
is_a: GO:0010851 ! cyclase regulator activity

[Term]
id: GO:0030250
name: guanylate cyclase activator activity
namespace: molecular_function
def: "Increases the activity of guanylate cyclase." [GOC:mah]
synonym: "guanylin" NARROW []
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0010853 ! cyclase activator activity
is_a: GO:0030249 ! guanylate cyclase regulator activity

[Term]
id: GO:0030251
name: guanylate cyclase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of guanylate cyclase." [GOC:mah]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0010852 ! cyclase inhibitor activity
is_a: GO:0030249 ! guanylate cyclase regulator activity

[Term]
id: GO:0030252
name: growth hormone secretion
namespace: biological_process
def: "The regulated release of growth hormone from secretory granules into the blood." [GOC:mah]
synonym: "somatotropin secretion" EXACT [GOC:mah]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0030253
name: protein secretion by the type I secretion system
namespace: biological_process
def: "The process by which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type I protein secretion system complex ; GO:0030256'.
synonym: "protein secretion by the TOSS" EXACT []
synonym: "protein secretion by the type I protein secretion system" EXACT []
synonym: "type I protein secretion system" EXACT []
is_a: GO:0009306 ! protein secretion

[Term]
id: GO:0030254
name: protein secretion by the type III secretion system
namespace: biological_process
def: "The process by which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type III protein secretion system complex ; GO:0030257'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted.
subset: gosubset_prok
synonym: "protein secretion by the T3S" EXACT []
synonym: "protein secretion by the T3SS" EXACT []
synonym: "protein secretion by the TTSS" EXACT []
synonym: "protein secretion by the type III protein secretion system" EXACT []
synonym: "type III protein secretion system" EXACT []
is_a: GO:0009306 ! protein secretion

[Term]
id: GO:0030255
name: protein secretion by the type IV secretion system
namespace: biological_process
def: "The process by which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type IV protein secretion system complex ; GO:0043684'.
subset: gosubset_prok
synonym: "protein secretion by the T4SS" EXACT []
synonym: "protein secretion by the type IV protein secretion system" EXACT []
synonym: "type IV protein secretion system" NARROW []
is_a: GO:0009306 ! protein secretion
is_a: GO:0044097 ! secretion by the type IV secretion system

[Term]
id: GO:0030256
name: type I protein secretion system complex
namespace: cellular_component
def: "A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space." [PMID:9618447]
subset: gosubset_prok
synonym: "ABC translocator complex" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030257
name: type III protein secretion system complex
namespace: cellular_component
def: "A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase." [PMID:9618447]
subset: gosubset_prok
synonym: "T3SS complex" EXACT []
synonym: "TTSS complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030258
name: lipid modification
namespace: biological_process
def: "The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah]
subset: gosubset_prok
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0030259
name: lipid glycosylation
namespace: biological_process
def: "Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0030260
name: entry into host cell
namespace: biological_process
def: "The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:njm]
subset: gosubset_prok
synonym: "host cell invasion" EXACT []
xref: Reactome:173107 "Binding and entry of HIV virion"
is_a: GO:0044409 ! entry into host
is_a: GO:0051806 ! entry into cell of other organism during symbiotic interaction

[Term]
id: GO:0030261
name: chromosome condensation
namespace: biological_process
alt_id: GO:0000068
def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194]
is_a: GO:0006323 ! DNA packaging
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0030262
name: apoptotic nuclear changes
namespace: biological_process
def: "The morphological and physiological alterations undergone by the nucleus during apoptosis." [GOC:mah]
is_a: GO:0006997 ! nucleus organization
relationship: part_of GO:0006915 ! apoptosis

[Term]
id: GO:0030263
name: apoptotic chromosome condensation
namespace: biological_process
def: "The compaction of chromatin during apoptosis." [GOC:mah]
synonym: "pyknosis" EXACT []
xref: Wikipedia:Pyknosis
is_a: GO:0030261 ! chromosome condensation
relationship: part_of GO:0030262 ! apoptotic nuclear changes

[Term]
id: GO:0030264
name: nuclear fragmentation during apoptosis
namespace: biological_process
def: "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA." [GOC:mah, ISBN:0721639976]
synonym: "apoptotic nuclear fragmentation" EXACT []
synonym: "nucleus fragmentation" EXACT []
is_a: GO:0006921 ! cell structure disassembly during apoptosis
relationship: part_of GO:0030262 ! apoptotic nuclear changes

[Term]
id: GO:0030265
name: rhodopsin mediated G-protein signaling, coupled to IP3 second messenger
namespace: biological_process
def: "The series of molecular signals generated as a consequence of light impinging on rhodopsin molecules in a photoreceptor cell, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:mah]
synonym: "rhodopsin mediated G protein signaling, coupled to IP3 second messenger" EXACT []
synonym: "rhodopsin mediated G protein signalling, coupled to IP3 second messenger" EXACT []
synonym: "rhodopsin mediated G-protein signalling, coupled to IP3 second messenger" EXACT []
is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
relationship: part_of GO:0016056 ! rhodopsin mediated signaling pathway

[Term]
id: GO:0030266
name: quinate 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: quinate + NAD+ = 5-dehydroquinate + NADH + H+." [EC:1.1.1.24]
synonym: "quinate:NAD oxidoreductase activity" EXACT [EC:1.1.1.24]
synonym: "quinate:NAD(+) 5-oxidoreductase activity" EXACT [EC:1.1.1.24]
synonym: "quinic dehydrogenase activity" EXACT [EC:1.1.1.24]
xref: EC:1.1.1.24
xref: MetaCyc:QUINATE-5-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0030267
name: glyoxylate reductase (NADP) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [EC:1.1.1.79]
subset: gosubset_prok
synonym: "glycolate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.79]
synonym: "glyoxylate reductase (NADP+)" EXACT [EC:1.1.1.79]
synonym: "NADPH-glyoxylate reductase activity" EXACT [EC:1.1.1.79]
xref: EC:1.1.1.79
xref: MetaCyc:GLYOXYLATE-REDUCTASE-NADP+-RXN
xref: Reactome:21773 "glyoxylate reductase (NADP) activity"
xref: Wikipedia:Glyoxylate_reductase_(NADP+)
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0030268
name: methylenetetrahydromethanopterin dehydrogenase activity
namespace: molecular_function
alt_id: GO:0018536
def: "Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420." [EC:1.5.99.9]
subset: gosubset_prok
synonym: "5,10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.5.99.9]
synonym: "5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.9]
synonym: "N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.5.99.9]
xref: EC:1.5.99.9
xref: MetaCyc:1.5.99.9-RXN
xref: UM-BBD_enzymeID:e0124
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0030269
name: tetrahydromethanopterin S-methyltransferase activity
namespace: molecular_function
alt_id: GO:0018709
def: "Catalysis of the reaction: 5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate. 2-(methylthio)ethanesulfonate is also known as methyl-CoM." [EC:2.1.1.86]
subset: gosubset_prok
synonym: "5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase activity" EXACT [EC:2.1.1.86]
synonym: "N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" EXACT [EC:2.1.1.86]
synonym: "N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" EXACT [EC:2.1.1.86]
synonym: "tetrahydromethanopterin methyltransferase activity" EXACT [EC:2.1.1.86]
xref: EC:2.1.1.86
xref: MetaCyc:2.1.1.86-RXN
xref: UM-BBD_enzymeID:e0145
is_a: GO:0008172 ! S-methyltransferase activity
is_a: GO:0042086 ! 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity

[Term]
id: GO:0030270
name: formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity
namespace: molecular_function
alt_id: GO:0018714
def: "Catalysis of the reaction: formylmethanofuran + 5,6,7,8-tetrahydromethanopterin = methanofuran + N5-formyl-5,6,7,8-tetrahydromethanopterin." [EC:2.3.1.101]
subset: gosubset_prok
synonym: "formylmethanofuran-tetrahydromethanopterin formyltransferase activity" EXACT [EC:2.3.1.101]
synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase activity" EXACT [EC:2.3.1.101]
synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase activity" EXACT [EC:2.3.1.101]
synonym: "formylmethanofuran:tetrahydromethanopterin formyltransferase activity" EXACT [EC:2.3.1.101]
synonym: "FTR" RELATED [EC:2.3.1.101]
synonym: "N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase activity" EXACT [EC:2.3.1.101]
xref: EC:2.3.1.101
xref: MetaCyc:2.3.1.101-RXN
xref: UM-BBD_enzymeID:e0143
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0030271
name: chymase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa." [EC:3.4.21.39]
comment: This term was made obsolete because it represents a gene product.
synonym: "mast cell protease I activity" NARROW [EC:3.4.21.39]
synonym: "mast cell serine proteinase" NARROW [EC:3.4.21.39]
synonym: "SK protease activity" EXACT [EC:3.4.21.39]
synonym: "skeletal muscle (SK) protease activity" NARROW [EC:3.4.21.39]
synonym: "skeletal muscle protease" NARROW [EC:3.4.21.39]
synonym: "skin chymotryptic proteinase" NARROW [EC:3.4.21.39]
xref: EC:3.4.21.39
xref: MetaCyc:3.4.21.39-RXN
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0030272
name: 5-formyltetrahydrofolate cyclo-ligase activity
namespace: molecular_function
alt_id: GO:0019006
def: "Catalysis of the reaction: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate." [EC:6.3.3.2]
subset: gosubset_prok
synonym: "5,10-methenyltetrahydrofolate synthetase activity" EXACT [EC:6.3.3.2]
synonym: "5-formyltetrahydrofolate cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.2]
synonym: "5-formyltetrahydrofolate cyclodehydrase" BROAD [EC:6.3.3.2]
synonym: "5-Formyltetrahydrofolate cyclodehydrase activity" EXACT [EC:6.3.3.2]
synonym: "formyltetrahydrofolic cyclodehydrase activity" EXACT [EC:6.3.3.2]
synonym: "methenyl-THF synthetase activity" EXACT [EC:6.3.3.2]
xref: EC:6.3.3.2
xref: MetaCyc:5-FORMYL-THF-CYCLO-LIGASE-RXN
is_a: GO:0016882 ! cyclo-ligase activity

[Term]
id: GO:0030273
name: melanin-concentrating hormone receptor activity
namespace: molecular_function
def: "Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity." [GOC:mah]
synonym: "MCH receptor" EXACT []
is_a: GO:0016500 ! protein-hormone receptor activity

[Term]
id: GO:0030274
name: LIM domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions." [GOC:go_curators, Pfam:PF00412]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0030275
name: LRR domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein." [GOC:go_curators, Pfam:PF00560]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0030276
name: clathrin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030277
name: maintenance of gastrointestinal epithelium
namespace: biological_process
def: "Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents." [GOC:mah]
is_a: GO:0010669 ! epithelial structure maintenance
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0030278
name: regulation of ossification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone formation." [GOC:go_curators]
synonym: "regulation of bone biosynthesis" EXACT []
synonym: "regulation of bone formation" EXACT []
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0001503 ! ossification

[Term]
id: GO:0030279
name: negative regulation of ossification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone formation." [GOC:go_curators]
synonym: "down regulation of ossification" EXACT []
synonym: "down-regulation of ossification" EXACT []
synonym: "downregulation of ossification" EXACT []
synonym: "inhibition of ossification" NARROW []
synonym: "negative regulation of bone biosynthesis" EXACT []
synonym: "negative regulation of bone formation" EXACT []
is_a: GO:0030278 ! regulation of ossification
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0001503 ! ossification

[Term]
id: GO:0030280
name: structural constituent of epidermis
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0030281
name: structural constituent of cutaneous appendage
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers." [GOC:mah, ISBN:0878932437]
is_a: GO:0030280 ! structural constituent of epidermis

[Term]
id: GO:0030282
name: bone mineralization
namespace: biological_process
def: "The deposition of calcium phosphate in bone tissue." [GOC:mah]
synonym: "bone calcification" NARROW []
is_a: GO:0031214 ! biomineral formation
relationship: part_of GO:0001503 ! ossification

[Term]
id: GO:0030283
name: 3(or 17)beta-hydroxysteroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+." [EC:1.1.1.51]
subset: gosubset_prok
synonym: "17beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.51]
synonym: "3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase" EXACT [EC:1.1.1.51]
synonym: "3beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.51]
synonym: "3beta-hydroxysteroid dehydrogenase" EXACT [EC:1.1.1.51]
synonym: "beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.51]
xref: EC:1.1.1.51
xref: MetaCyc:1.1.1.51-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0030284
name: estrogen receptor activity
namespace: molecular_function
def: "Combining with estrogen to initiate a change in cell activity." [GOC:ai]
comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'.
is_a: GO:0003707 ! steroid hormone receptor activity

[Term]
id: GO:0030285
name: integral to synaptic vesicle membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a synaptic vesicle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators]
is_a: GO:0031301 ! integral to organelle membrane
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030672 ! synaptic vesicle membrane

[Term]
id: GO:0030286
name: dynein complex
namespace: cellular_component
def: "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]
is_a: GO:0005875 ! microtubule associated complex

[Term]
id: GO:0030287
name: cell wall-bounded periplasmic space
namespace: cellular_component
def: "The region between the plasma membrane and the cell wall, as found in organisms such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria." [GOC:mlg, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "cell wall bounded periplasmic space" EXACT []
synonym: "cell wall-enclosed periplasmic space" EXACT []
is_a: GO:0042597 ! periplasmic space

[Term]
id: GO:0030288
name: outer membrane-bounded periplasmic space
namespace: cellular_component
def: "The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall." [GOC:mlg, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "outer membrane bounded periplasmic space" EXACT []
synonym: "outer membrane-enclosed periplasmic space" EXACT []
xref: Wikipedia:Periplasmic_space
is_a: GO:0042597 ! periplasmic space
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0030313 ! cell envelope

[Term]
id: GO:0030289
name: protein phosphatase 4 complex
namespace: cellular_component
def: "The complex formed by the catalytic subunit of protein phosphatase 4 plus a regulatory subunit." [PMID:10026142]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0030290
name: sphingolipid activator protein activity
namespace: molecular_function
def: "Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "saposin" NARROW []
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0030291
name: protein serine/threonine kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a protein serine/threonine kinase." [GOC:mah]
is_a: GO:0004860 ! protein kinase inhibitor activity

[Term]
id: GO:0030292
name: protein tyrosine kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a protein tyrosine kinase." [GOC:mah]
is_a: GO:0004860 ! protein kinase inhibitor activity

[Term]
id: GO:0030293
name: transmembrane receptor protein tyrosine kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah]
is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity
is_a: GO:0030547 ! receptor inhibitor activity

[Term]
id: GO:0030294
name: receptor signaling protein tyrosine kinase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase." [GOC:mah]
synonym: "receptor signalling protein tyrosine kinase inhibitor activity" EXACT []
is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity

[Term]
id: GO:0030295
name: protein kinase activator activity
namespace: molecular_function
def: "Increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0019209 ! kinase activator activity
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0030296
name: protein tyrosine kinase activator activity
namespace: molecular_function
def: "Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0030295 ! protein kinase activator activity

[Term]
id: GO:0030297
name: transmembrane receptor protein tyrosine kinase activator activity
namespace: molecular_function
def: "Increases the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah]
is_a: GO:0030296 ! protein tyrosine kinase activator activity
is_a: GO:0030546 ! receptor activator activity

[Term]
id: GO:0030298
name: receptor signaling protein tyrosine kinase activator activity
namespace: molecular_function
def: "Increases the activity of a receptor signaling protein tyrosine kinase." [GOC:mah]
synonym: "receptor signalling protein tyrosine kinase activator activity" EXACT []
is_a: GO:0030296 ! protein tyrosine kinase activator activity

[Term]
id: GO:0030299
name: intestinal cholesterol absorption
namespace: biological_process
def: "Uptake of cholesterol into the blood by absorption from the small intestine." [GOC:mah]
is_a: GO:0030301 ! cholesterol transport
is_a: GO:0050892 ! intestinal absorption
relationship: part_of GO:0044241 ! lipid digestion

[Term]
id: GO:0030300
name: regulation of intestinal cholesterol absorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption." [GOC:mah, PMID:11099417]
is_a: GO:0032374 ! regulation of cholesterol transport
is_a: GO:0044058 ! regulation of digestive system process
relationship: regulates GO:0030299 ! intestinal cholesterol absorption

[Term]
id: GO:0030301
name: cholesterol transport
namespace: biological_process
def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0015918 ! sterol transport

[Term]
id: GO:0030302
name: deoxynucleotide transport
namespace: biological_process
def: "The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of its deoxyribose moiety, into, out of or within a cell." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0006862 ! nucleotide transport

[Term]
id: GO:0030303
name: stromelysin 2 activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak." [EC:3.4.24.17, EC:3.4.24.22]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 10 activity" EXACT [EC:3.4.24.22]
synonym: "MMP-10" EXACT []
synonym: "proteoglycanase 2" RELATED [EC:3.4.24.22]
synonym: "transin 2 activity" EXACT [EC:3.4.24.22]
xref: EC:3.4.24.22
xref: MetaCyc:3.4.24.22-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0030304
name: trypsin inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase trypsin." [GOC:ai]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
subset: gosubset_prok
is_obsolete: true
replaced_by: GO:0004867

[Term]
id: GO:0030305
name: heparanase activity
namespace: molecular_function
def: "Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains." [PMID:10916150]
synonym: "heparinase activity" RELATED []
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0030306
name: ADP-ribosylation factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "ARF binding" EXACT []
is_a: GO:0031267 ! small GTPase binding

[Term]
id: GO:0030307
name: positive regulation of cell growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell growth." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of cell growth" NARROW []
synonym: "stimulation of cell growth" NARROW []
synonym: "up regulation of cell growth" EXACT []
synonym: "up-regulation of cell growth" EXACT []
synonym: "upregulation of cell growth" EXACT []
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0045927 ! positive regulation of growth
is_a: GO:0048522 ! positive regulation of cellular process
relationship: part_of GO:0045793 ! positive regulation of cell size
relationship: positively_regulates GO:0016049 ! cell growth

[Term]
id: GO:0030308
name: negative regulation of cell growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell growth." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of cell growth" EXACT []
synonym: "down-regulation of cell growth" EXACT []
synonym: "downregulation of cell growth" EXACT []
synonym: "inhibition of cell growth" NARROW []
xref: Reactome:110491 "DRheb is inhibited by the TSC1/2 complex"
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0045926 ! negative regulation of growth
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0016049 ! cell growth
relationship: part_of GO:0045792 ! negative regulation of cell size

[Term]
id: GO:0030309
name: poly-N-acetyllactosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606]
subset: gosubset_prok
synonym: "poly-N-acetyllactosamine metabolism" EXACT []
is_a: GO:0006022 ! aminoglycan metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0030310
name: poly-N-acetyllactosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606]
subset: gosubset_prok
synonym: "poly-N-acetyllactosamine breakdown" EXACT []
synonym: "poly-N-acetyllactosamine catabolism" EXACT []
synonym: "poly-N-acetyllactosamine degradation" EXACT []
is_a: GO:0006026 ! aminoglycan catabolic process
is_a: GO:0030309 ! poly-N-acetyllactosamine metabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process

[Term]
id: GO:0030311
name: poly-N-acetyllactosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606]
subset: gosubset_prok
synonym: "poly-N-acetyllactosamine anabolism" EXACT []
synonym: "poly-N-acetyllactosamine biosynthesis" EXACT []
synonym: "poly-N-acetyllactosamine formation" EXACT []
synonym: "poly-N-acetyllactosamine synthesis" EXACT []
is_a: GO:0006023 ! aminoglycan biosynthetic process
is_a: GO:0030309 ! poly-N-acetyllactosamine metabolic process
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process

[Term]
id: GO:0030312
name: external encapsulating structure
namespace: cellular_component
def: "A structure that lies outside the plasma membrane and surrounds the entire cell." [GOC:go_curators]
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030313
name: cell envelope
namespace: cellular_component
def: "An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:ds, GOC:mlg, http://pathmicro.med.sc.edu/fox/cell_envelope.htm]
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Cell_envelope
is_a: GO:0031975 ! envelope

[Term]
id: GO:0030314
name: junctional membrane complex
namespace: cellular_component
def: "Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules)." [PMID:11535622]
synonym: "triad junction" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0016528 ! sarcoplasm

[Term]
id: GO:0030315
name: T-tubule
namespace: cellular_component
def: "Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane." [GOC:mtg_muscle, ISBN:0815316194]
synonym: "transverse tubule" EXACT []
synonym: "triad" RELATED []
xref: Wikipedia:T-tubule
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0042383 ! sarcolemma

[Term]
id: GO:0030316
name: osteoclast differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized monocyte acquires the specialized features of a osteoclast cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12161749]
synonym: "osteoclast cell differentiation" EXACT []
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0030317
name: sperm motility
namespace: biological_process
def: "Any process involved in the controlled movement of a sperm cell." [GOC:jl]
synonym: "sperm movement" EXACT []
xref: Wikipedia:Sperm_motility
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0030318
name: melanocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a melanocyte." [GOC:mah]
synonym: "melanocyte cell differentiation" EXACT []
synonym: "melanophore differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0030319
name: cellular di-, tri-valent inorganic anion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of divalent or trivalent inorganic anions at the level of a cell." [GOC:ai, GOC:mah]
is_a: GO:0030002 ! cellular anion homeostasis
is_a: GO:0055061 ! di-, tri-valent inorganic anion homeostasis

[Term]
id: GO:0030320
name: cellular monovalent inorganic anion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of monovalent inorganic anions at the level of a cell." [GOC:ai, GOC:mah]
is_a: GO:0030002 ! cellular anion homeostasis
is_a: GO:0055083 ! monovalent inorganic anion homeostasis

[Term]
id: GO:0030321
name: transepithelial chloride transport
namespace: biological_process
def: "The directed movement of chloride ions from one side of an epithelium to the other." [GOC:mah]
is_a: GO:0006821 ! chloride transport
is_a: GO:0070633 ! transepithelial transport

[Term]
id: GO:0030322
name: stabilization of membrane potential
namespace: biological_process
def: "The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0030323
name: respiratory tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jic]
is_a: GO:0035295 ! tube development
is_a: GO:0048513 ! organ development

[Term]
id: GO:0030324
name: lung development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0048513 ! organ development
relationship: part_of GO:0030323 ! respiratory tube development
relationship: part_of GO:0060541 ! respiratory system development

[Term]
id: GO:0030325
name: adrenal gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells." [GOC:dgh]
synonym: "interrenal gland" RELATED []
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0030326
name: embryonic limb morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. Morphogenesis pertains to the creation of form. A limb is an appendage of an animal used for locomotion or grasping." [GOC:bf, GOC:jl, ISBN:0395825172]
is_a: GO:0035108 ! limb morphogenesis
is_a: GO:0035113 ! embryonic appendage morphogenesis

[Term]
id: GO:0030327
name: prenylated protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of prenylated proteins." [GOC:mah]
subset: gosubset_prok
synonym: "prenylated protein breakdown" EXACT []
synonym: "prenylated protein catabolism" EXACT []
synonym: "prenylated protein degradation" EXACT []
is_a: GO:0019941 ! modification-dependent protein catabolic process

[Term]
id: GO:0030328
name: prenylcysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai]
subset: gosubset_prok
synonym: "prenylcysteine breakdown" EXACT []
synonym: "prenylcysteine catabolism" EXACT []
synonym: "prenylcysteine degradation" EXACT []
is_a: GO:0030329 ! prenylcysteine metabolic process
is_a: GO:0042219 ! cellular amino acid derivative catabolic process

[Term]
id: GO:0030329
name: prenylcysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "prenylcysteine metabolism" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process

[Term]
id: GO:0030330
name: DNA damage response, signal transduction by p53 class mediator
namespace: biological_process
alt_id: GO:0006976
def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:go_curators]
synonym: "DNA damage response, activation of p53" RELATED []
synonym: "p53 signaling pathway" RELATED [GOC:mah, GOC:vk]
synonym: "p53-mediated DNA damage response" BROAD []
synonym: "TP53 signaling pathway" RELATED [GOC:mah, GOC:vk]
is_a: GO:0042770 ! DNA damage response, signal transduction

[Term]
id: GO:0030331
name: estrogen receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an estrogen receptor." [GOC:ai]
is_a: GO:0035258 ! steroid hormone receptor binding

[Term]
id: GO:0030332
name: cyclin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030334
name: regulation of cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators]
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0051270 ! regulation of cellular component movement
relationship: regulates GO:0016477 ! cell migration

[Term]
id: GO:0030335
name: positive regulation of cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of cell migration" NARROW []
synonym: "stimulation of cell migration" NARROW []
synonym: "up regulation of cell migration" EXACT []
synonym: "up-regulation of cell migration" EXACT []
synonym: "upregulation of cell migration" EXACT []
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0051272 ! positive regulation of cellular component movement
relationship: positively_regulates GO:0016477 ! cell migration

[Term]
id: GO:0030336
name: negative regulation of cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]
synonym: "down regulation of cell migration" EXACT []
synonym: "down-regulation of cell migration" EXACT []
synonym: "downregulation of cell migration" EXACT []
synonym: "inhibition of cell migration" NARROW []
is_a: GO:0030334 ! regulation of cell migration
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0051271 ! negative regulation of cellular component movement
relationship: negatively_regulates GO:0016477 ! cell migration

[Term]
id: GO:0030337
name: DNA polymerase processivity factor activity
namespace: molecular_function
def: "An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it." [GOC:mah, PMID:7903401, PMID:8087839]
subset: gosubset_prok
synonym: "processivity clamp" EXACT []
synonym: "sliding clamp" EXACT []
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0030338
name: CMP-N-acetylneuraminate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O." [EC:1.14.18.2]
comment: Note that this was EC:1.14.13.45.
synonym: "CMP-N-acetylneuraminate hydroxylase activity" EXACT [EC:1.14.18.2]
synonym: "CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating)" EXACT [EC:1.14.18.2]
synonym: "CMP-N-acetylneuraminic acid hydroxylase activity" EXACT []
synonym: "CMP-Neu5Ac hydroxylase activity" EXACT [EC:1.14.18.2]
synonym: "cytidine monophosphoacetylneuraminate monooxygenase activity" EXACT [EC:1.14.18.2]
synonym: "cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase activity" EXACT [EC:1.14.18.2]
synonym: "N-acetylneuraminic monooxygenase activity" EXACT [EC:1.14.18.2]
xref: EC:1.14.18.2
xref: MetaCyc:1.14.13.45-RXN
is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0030339
name: fatty-acyl-ethyl-ester synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol." [EC:3.1.1.67]
synonym: "FAEE synthase activity" EXACT [EC:3.1.1.67]
synonym: "FAEES activity" EXACT [EC:3.1.1.67]
synonym: "long-chain-fatty-acyl-ethyl-ester acylhydrolase activity" EXACT [EC:3.1.1.67]
xref: EC:3.1.1.67
xref: MetaCyc:FATTY-ACYL-ETHYL-ESTER-SYNTHASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0030340
name: hyaluronate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine." [EC:4.2.2.1]
subset: gosubset_prok
synonym: "glucuronoglycosaminoglycan lyase activity" EXACT [EC:4.2.2.1]
synonym: "hyaluronidase [but cf. EC 3.2.1.35 (hyalurononglucosaminidase) and EC 3.2.1.36 (hyaluronoglucuronidase)]" RELATED [EC:4.2.2.1]
synonym: "hyaluronidase activity" BROAD [EC:4.2.2.1]
synonym: "mucinase activity" EXACT [EC:4.2.2.1]
synonym: "spreading factor activity" RELATED [EC:4.2.2.1]
xref: EC:4.2.2.1
xref: MetaCyc:HYALURONATE-LYASE-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0030341
name: chondroitin AC lyase activity
namespace: molecular_function
def: "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [EC:4.2.2.5]
subset: gosubset_prok
synonym: "ChnAC" RELATED []
synonym: "chondroitin AC eliminase activity" EXACT [EC:4.2.2.5]
synonym: "chondroitin lyase activity" EXACT []
synonym: "chondroitin sulfate lyase activity" EXACT [EC:4.2.2.5]
synonym: "chondroitinase AC" RELATED []
synonym: "chondroitinase activity" BROAD []
xref: EC:4.2.2.5
xref: MetaCyc:4.2.2.5-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0030342
name: 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol)." [PMID:8506296]
synonym: "1,25-(OH)2D3 24-hydroxylase activity" EXACT [PMID:8506296]
synonym: "calcitriol 24-hydroxylase activity" EXACT [ChEBI:17823, GOC:mah]
xref: Reactome:22681 "1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity"
is_a: GO:0070576 ! vitamin D 24-hydroxylase activity

[Term]
id: GO:0030343
name: vitamin D3 25-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O." [ISBN:0471331309 "Biochemical Pathways", MetaCyc:RXN-9829]
synonym: "cholecalciferol 25-hydroxylase activity" EXACT []
xref: MetaCyc:RXN-9829
xref: Reactome:22682 "vitamin D3 25-hydroxylase activity"
is_a: GO:0070643 ! vitamin D 25-hydroxylase activity

[Term]
id: GO:0030345
name: structural constituent of tooth enamel
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of tooth enamel." [GOC:mah]
is_a: GO:0030021 ! extracellular matrix structural constituent conferring compression resistance

[Term]
id: GO:0030346
name: protein phosphatase 2B binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 2B." [GOC:jl]
synonym: "calcineurin binding" EXACT []
is_a: GO:0019903 ! protein phosphatase binding

[Term]
id: GO:0030347
name: syntaxin-2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-2." [GOC:ai]
is_a: GO:0019905 ! syntaxin binding

[Term]
id: GO:0030348
name: syntaxin-3 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-3." [GOC:ai]
is_a: GO:0019905 ! syntaxin binding

[Term]
id: GO:0030349
name: syntaxin-13 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-13." [GOC:ai]
is_a: GO:0019905 ! syntaxin binding

[Term]
id: GO:0030350
name: iron-responsive element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins." [PMID:3198610, PMID:8710843]
synonym: "IRE binding" EXACT []
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:0030351
name: inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate." [GOC:ai]
xref: EC:3.1.3.-
is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity

[Term]
id: GO:0030352
name: inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:ai]
xref: EC:3.1.3.-
is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity

[Term]
id: GO:0030353
name: fibroblast growth factor receptor antagonist activity
namespace: molecular_function
def: "Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist." [GOC:mah]
synonym: "FGF receptor antagonist activity" EXACT []
synonym: "FGFR antagonist activity" EXACT []
is_a: GO:0005104 ! fibroblast growth factor receptor binding
is_a: GO:0048019 ! receptor antagonist activity

[Term]
id: GO:0030354
name: melanin-concentrating hormone activity
namespace: molecular_function
def: "The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals." [GOC:mah, PMID:11416225, PMID:9792536]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0030355
name: small nucleolar ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
synonym: "snoRNP" EXACT []
is_obsolete: true
replaced_by: GO:0005732

[Term]
id: GO:0030356
name: small cytoplasmic ribonucleoprotein
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it describes a cellular component rather than a molecular function.
synonym: "scRNP" EXACT []
is_obsolete: true
replaced_by: GO:0030531

[Term]
id: GO:0030359
name: protein phosphatase type 2B regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme protein phosphatase type 2B." [GOC:ai]
synonym: "protein phosphatase type 2B, intrinsic regulator activity" NARROW []
is_a: GO:0019888 ! protein phosphatase regulator activity

[Term]
id: GO:0030362
name: protein phosphatase type 4 regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme protein phosphatase type 4." [GOC:ai]
synonym: "protein phosphatase type 4, intrinsic regulator activity" NARROW []
is_a: GO:0019888 ! protein phosphatase regulator activity

[Term]
id: GO:0030363
name: pre-mRNA cleavage factor activity
namespace: molecular_function
def: "OBSOLETE. Any activity required for the process of mRNA cleavage." [GOC:mah, PMID:10357856]
comment: This term was made obsolete because it describes a biological process.
is_obsolete: true
consider: GO:0006379

[Term]
id: GO:0030364
name: cleavage and polyadenylylation specificity factor activity
namespace: molecular_function
def: "OBSOLETE. A factor required in mRNA 3' end processing for both the cleavage and poly(A) addition reactions and, consistent with this function, recognizes AAUAAA, a signal also essential for both reactions." [PMID:10357856]
comment: This term was made obsolete because it describes a cellular component.
synonym: "cleavage and polyadenylation specificity factor activity" EXACT []
synonym: "cleavage/polyadenylation specificity factor activity" EXACT []
synonym: "CPSF" EXACT []
is_obsolete: true
replaced_by: GO:0005847
consider: GO:0006378
consider: GO:0006379

[Term]
id: GO:0030365
name: cleavage stimulation factor activity
namespace: molecular_function
def: "OBSOLETE. A factor is necessary for cleavage but not for poly(A) addition in mRNA 3' end processing; can stimulate poly(A) addition on substrates with a CstF binding site upstream of the AAUAAA hexanucleotide." [PMID:10357856]
comment: This term was made obsolete because it describes a cellular component.
synonym: "CstF" EXACT []
is_obsolete: true
replaced_by: GO:0005848
consider: GO:0006379

[Term]
id: GO:0030366
name: Mo-molybdopterin synthase activity
namespace: molecular_function
def: "Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis." [PMID:8514783]
synonym: "molybdopterin synthase activity" EXACT []
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0030367
name: interleukin-17 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-17 receptor." [GOC:ai]
synonym: "IL-17" NARROW []
synonym: "interleukin-17 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0030368
name: interleukin-17 receptor activity
namespace: molecular_function
def: "Combining with interleukin-17 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-17 receptor activity" EXACT [GOC:mah]
synonym: "IL-17R" EXACT []
xref: Wikipedia:Interleukin-17_receptor
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0019975 ! interleukin-17 binding

[Term]
id: GO:0030369
name: ICAM-3 receptor activity
namespace: molecular_function
def: "Combining with ICAM-3, intercellular adhesion molecule 3, to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'.
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0030370
name: intercellular adhesion molecule-3 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with receptors for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1." [GOC:ceb, PMID:11473836]
synonym: "ICAM-3 receptor binding" EXACT []
synonym: "ICAM-3 receptor ligand" NARROW []
synonym: "intercellular adhesion molecule-3 receptor ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0030371
name: translation repressor activity
namespace: molecular_function
def: "Antagonizes ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai, GOC:clt]
is_a: GO:0045182 ! translation regulator activity

[Term]
id: GO:0030372
name: high molecular weight B cell growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the high molecular weight B cell growth factor receptor." [GOC:ai]
synonym: "high molecular weight B cell growth factor receptor ligand" NARROW []
synonym: "high molecular weight B lymphocyte growth factor receptor binding" EXACT []
synonym: "high molecular weight B-cell growth factor receptor binding" EXACT []
synonym: "high molecular weight B-lymphocyte growth factor receptor binding" EXACT []
is_a: GO:0070851 ! growth factor receptor binding

[Term]
id: GO:0030373
name: high molecular weight B cell growth factor receptor activity
namespace: molecular_function
def: "Combining with a high molecular weight B cell growth factor to initiate a change in cell activity." [GOC:ai]
synonym: "high molecular weight B lymphocyte growth factor receptor activity" EXACT []
synonym: "high molecular weight B-cell growth factor receptor activity" EXACT []
synonym: "high molecular weight B-lymphocyte growth factor receptor activity" EXACT []
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0030374
name: ligand-dependent nuclear receptor transcription coactivator activity
namespace: molecular_function
def: "The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb]
synonym: "ligand-dependent nuclear receptor transcription co-activator activity" EXACT []
is_a: GO:0003713 ! transcription coactivator activity

[Term]
id: GO:0030375
name: thyroid hormone receptor coactivator activity
namespace: molecular_function
def: "The function of a transcription cofactor that activates transcription in conjuction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb]
synonym: "thyroid hormone receptor co-activator activity" EXACT []
is_a: GO:0010861 ! thyroid hormone receptor activator activity
is_a: GO:0030374 ! ligand-dependent nuclear receptor transcription coactivator activity

[Term]
id: GO:0030377
name: U-plasminogen activator receptor activity
namespace: molecular_function
def: "Combining with the urokinase plasminogen activator to initiate a change in cell activity." [GOC:mah, PMID:16456079]
synonym: "uPAR" EXACT []
synonym: "urokinase plasminogen activator receptor" EXACT []
xref: Wikipedia:Urokinase_receptor
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0030378
name: serine racemase activity
namespace: molecular_function
def: "Catalysis of the synthesis of free D-serine from L-serine." [GOC:kd]
xref: MetaCyc:5.1.1.18-RXN
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0030379
name: neurotensin receptor activity, non-G-protein coupled
namespace: molecular_function
def: "Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, to initiate a change in cell activity by a mechanism independent of coupling to G proteins." [GOC:mah, PMID:9756851]
synonym: "neurotensin receptor activity, non G protein coupled" EXACT []
synonym: "non G protein coupled neurotensin receptor activity" EXACT []
synonym: "non-G-protein coupled neurotensin receptor activity" EXACT []
synonym: "non-G-protein-coupled neurotensin receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0030380
name: interleukin-17E receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-17E receptor." [GOC:ai]
synonym: "IL-17E" NARROW []
synonym: "interleukin-17E receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0030381
name: chorion-containing eggshell pattern formation
namespace: biological_process
def: "The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0007304 ! chorion-containing eggshell formation

[Term]
id: GO:0030382
name: sperm mitochondrion organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process by which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144]
synonym: "sperm mitochondria organisation" EXACT [GOC:curators]
synonym: "sperm mitochondria organization and biogenesis" RELATED [GOC:mah]
synonym: "sperm mitochondrion organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007005 ! mitochondrion organization

[Term]
id: GO:0030383
name: host-pathogen interaction
namespace: biological_process
def: "OBSOLETE. Any interaction between a pathogen and its host organism." [GOC:jl]
comment: This term was made obsolete because more appropriate terms were created.
is_obsolete: true
consider: GO:0044403

[Term]
id: GO:0030384
name: phosphoinositide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphoinositides, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of inositol. They are important constituents of cell membranes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphoinositide metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process

[Term]
id: GO:0030385
name: ferredoxin:thioredoxin reductase activity
namespace: molecular_function
def: "Catalysis of the two-electron reduction of the disulfide of thioredoxins with electrons from ferredoxin involving a 4Fe-4S cluster and an adjacent active-site disulfide." [PMID:14769790]
is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors

[Term]
id: GO:0030386
name: ferredoxin:thioredoxin reductase complex
namespace: cellular_component
def: "A protein complex that possesses ferredoxin:thioredoxin reductase activity." [GOC:mah]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'ferredoxin:thioredoxin reductase activity ; GO:0030385'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0030387
name: fructosamine-3-kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of fructosamine to form fructosamine-3-kinase." [PMID:11016445]
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0030388
name: fructose 1,6-bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "fructose 1,6-bisphosphate metabolism" EXACT []
is_a: GO:0006000 ! fructose metabolic process

[Term]
id: GO:0030389
name: fructosamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "fructosamine metabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process

[Term]
id: GO:0030391
name: fructosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "fructosamine anabolism" EXACT []
synonym: "fructosamine biosynthesis" EXACT []
synonym: "fructosamine formation" EXACT []
synonym: "fructosamine synthesis" EXACT []
is_a: GO:0030389 ! fructosamine metabolic process
is_a: GO:0046349 ! amino sugar biosynthetic process

[Term]
id: GO:0030392
name: fructosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "fructosamine breakdown" EXACT []
synonym: "fructosamine catabolism" EXACT []
synonym: "fructosamine degradation" EXACT []
is_a: GO:0030389 ! fructosamine metabolic process
is_a: GO:0046348 ! amino sugar catabolic process

[Term]
id: GO:0030393
name: fructoselysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructoselysine, a fructose molecule containing a lysine moiety in place of a hydroxyl group." [GOC:ai]
subset: gosubset_prok
synonym: "fructoselysine metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0030389 ! fructosamine metabolic process

[Term]
id: GO:0030394
name: fructoseglycine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fructoseglycine, a fructose molecule containing a glycine moiety in place of a hydroxyl group." [GOC:ai]
subset: gosubset_prok
synonym: "fructoseglycine metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0030389 ! fructosamine metabolic process

[Term]
id: GO:0030395
name: lactose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk." [GOC:jl, ISBN:01928006X]
is_a: GO:0048030 ! disaccharide binding

[Term]
id: GO:0030397
name: membrane disassembly
namespace: biological_process
def: "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy." [GOC:mah]
synonym: "membrane breakdown" EXACT []
synonym: "membrane catabolism" EXACT []
synonym: "membrane degradation" EXACT []
is_a: GO:0016044 ! cellular membrane organization
is_a: GO:0022411 ! cellular component disassembly

[Term]
id: GO:0030398
name: peroxisomal membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the membranes of cargo-carrying vesicles formed during peroxisome degradation." [GOC:mah, PMID:11382760]
synonym: "peroxisomal membrane breakdown" EXACT []
synonym: "peroxisomal membrane catabolism" EXACT []
synonym: "peroxisomal membrane degradation" EXACT []
is_a: GO:0030397 ! membrane disassembly
relationship: part_of GO:0030242 ! peroxisome degradation

[Term]
id: GO:0030399
name: autophagic membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the membranes of autophagic vacuoles." [GOC:mah]
synonym: "autophagic membrane breakdown" EXACT []
synonym: "autophagic membrane catabolism" EXACT []
synonym: "autophagic membrane degradation" EXACT []
is_a: GO:0030397 ! membrane disassembly
relationship: part_of GO:0016236 ! macroautophagy

[Term]
id: GO:0030400
name: protease substrate recruitment factor activity
namespace: molecular_function
def: "OBSOLETE. A recruiting factor or adaptor molecule associated with the proteasome that activates degradation of specific proteasomal substrates and links them to the degradation machinery; it is not involved in ubiquitination; does not possess proteolytic activity." [PMID:11500370]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0030674

[Term]
id: GO:0030401
name: transcription antiterminator activity
namespace: molecular_function
def: "Functions to prevent the termination of RNA synthesis. Acts as a regulatory device, e.g. in phage lambda, enabling a terminator to be masked from RNA polymerase so that distal genes can be expressed." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "transcriptional antiterminator activity" EXACT []
is_a: GO:0030528 ! transcription regulator activity

[Term]
id: GO:0030402
name: matrilysin-2 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 26" EXACT []
synonym: "MMP-26" EXACT []
xref: EC:3.4.24.-
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0030403
name: collagenase 4 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 18" EXACT []
synonym: "MMP-18" NARROW []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0030404
name: collagenase 3 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "matrix metalloproteinase 13" EXACT []
synonym: "MMP-13" EXACT []
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0030405
name: matrix metalloproteinase 19 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "MMP-19" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0030406
name: matrix metalloproteinase 25 activity
namespace: molecular_function
def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "MMP-25" EXACT []
synonym: "MT6-MMP" EXACT []
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0030407
name: formimidoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a formimino group from 5-formimidoyltetrahydrofolate to an acceptor molecule such as an amino acid." [EC:2.1.2.4, EC:2.1.2.5, GOC:mah]
subset: gosubset_prok
synonym: "formiminotransferase activity" EXACT []
xref: EC:2.1.2.-
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0030408
name: glycine formimidoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = tetrahydrofolate + N-formimidoylglycine." [EC:2.1.2.4]
synonym: "5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase activity" EXACT [EC:2.1.2.4]
synonym: "FIG formiminotransferase activity" EXACT [EC:2.1.2.4]
synonym: "formiminoglycine formiminotransferase activity" EXACT [EC:2.1.2.4]
synonym: "glycine formiminotransferase activity" EXACT []
xref: EC:2.1.2.4
xref: MetaCyc:GLYCINE-FORMIMINOTRANSFERASE-RXN
is_a: GO:0030407 ! formimidoyltransferase activity

[Term]
id: GO:0030409
name: glutamate formimidoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate." [EC:2.1.2.5]
subset: gosubset_prok
synonym: "5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase activity" EXACT [EC:2.1.2.5]
synonym: "formiminoglutamic acid transferase activity" EXACT [EC:2.1.2.5]
synonym: "formiminoglutamic formiminotransferase activity" EXACT [EC:2.1.2.5]
synonym: "glutamate formiminotransferase activity" EXACT []
synonym: "glutamate formyltransferase activity" EXACT [EC:2.1.2.5]
xref: EC:2.1.2.5
xref: MetaCyc:GLUTAMATE-FORMIMINOTRANSFERASE-RXN
is_a: GO:0030407 ! formimidoyltransferase activity

[Term]
id: GO:0030410
name: nicotianamine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 S-adenosyl-L-methionine = 3 5'-S-methyl-5'-thioadenosine + nicotianamine." [EC:2.5.1.43]
subset: gosubset_prok
synonym: "S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.43]
xref: EC:2.5.1.43
xref: MetaCyc:2.5.1.43-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0030411
name: scytalone dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H2O." [EC:4.2.1.94]
synonym: "scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)" EXACT [EC:4.2.1.94]
synonym: "scytalone 7,8-hydro-lyase activity" EXACT [EC:4.2.1.94]
xref: EC:4.2.1.94
xref: MetaCyc:SCYTALONE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0030412
name: formimidoyltetrahydrofolate cyclodeaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3." [EC:4.3.1.4]
subset: gosubset_prok
synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)" EXACT [EC:4.3.1.4]
synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)" EXACT [EC:4.3.1.4]
synonym: "formiminotetrahydrofolate cyclodeaminase activity" EXACT [EC:4.3.1.4]
xref: EC:4.3.1.4
xref: MetaCyc:4.3.1.4-RXN
xref: Reactome:23291 "formimidoyltetrahydrofolate cyclodeaminase activity"
is_a: GO:0016841 ! ammonia-lyase activity
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0030413
name: competence pheromone activity
namespace: molecular_function
def: "A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence." [GOC:mah, PMID:7698645]
subset: gosubset_prok
is_a: GO:0005186 ! pheromone activity

[Term]
id: GO:0030414
name: peptidase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]
subset: gosubset_prok
synonym: "protease inhibitor activity" RELATED [GOC:mah]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0030415
name: carboxypeptidase A inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the enzyme carboxypeptidase A." [GOC:ai]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
is_obsolete: true
replaced_by: GO:0030414

[Term]
id: GO:0030416
name: methylamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methylamine (CH3NH2), a flammable, explosive gas, used in tanning and in organic synthesis and produced naturally in some decaying fish, certain plants, and crude methanol." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "methylamine metabolism" EXACT []
synonym: "methylammonium metabolic process" EXACT []
synonym: "methylammonium metabolism" EXACT []
is_a: GO:0009308 ! amine metabolic process

[Term]
id: GO:0030417
name: nicotianamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850]
subset: gosubset_prok
synonym: "nicotianamine metabolism" EXACT []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0030418
name: nicotianamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850]
subset: gosubset_prok
synonym: "nicotianamine anabolism" EXACT []
synonym: "nicotianamine biosynthesis" EXACT []
synonym: "nicotianamine formation" EXACT []
synonym: "nicotianamine synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0030417 ! nicotianamine metabolic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process

[Term]
id: GO:0030419
name: nicotianamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850]
subset: gosubset_prok
synonym: "nicotianamine breakdown" EXACT []
synonym: "nicotianamine catabolism" EXACT []
synonym: "nicotianamine degradation" EXACT []
is_a: GO:0030417 ! nicotianamine metabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0030420
name: establishment of competence for transformation
namespace: biological_process
def: "The process by which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation." [GOC:mah, ISBN:1555811027]
subset: gosubset_prok
is_a: GO:0031668 ! cellular response to extracellular stimulus
relationship: part_of GO:0009294 ! DNA mediated transformation

[Term]
id: GO:0030421
name: defecation
namespace: biological_process
def: "The expulsion of feces from the rectum." [GOC:mah]
xref: Wikipedia:Defecation
is_a: GO:0007588 ! excretion

[Term]
id: GO:0030422
name: production of siRNA involved in RNA interference
namespace: biological_process
def: "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674]
synonym: "production of guide RNAs involved in RNA interference" EXACT [GOC:mah]
synonym: "RNA interference, production of guide RNAs" EXACT []
synonym: "RNA interference, production of siRNA" EXACT [GOC:mah]
is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA
relationship: part_of GO:0016246 ! RNA interference

[Term]
id: GO:0030423
name: targeting of mRNA for destruction involved in RNA interference
namespace: biological_process
def: "The process by which small interfering RNAs target cognate mRNA molecules for degradation." [PMID:11524674]
synonym: "RNA interference, targeting of mRNA for destruction" EXACT [GOC:mah]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0016246 ! RNA interference

[Term]
id: GO:0030424
name: axon
namespace: cellular_component
def: "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: NIF_Subcellular:sao1770195789
xref: Wikipedia:Axon
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:0030425
name: dendrite
namespace: cellular_component
def: "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: NIF_Subcellular:sao1211023249
xref: Wikipedia:Dendrite
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:0030426
name: growth cone
namespace: cellular_component
def: "The migrating motile tip of a growing nerve cell axon or dendrite." [ISBN:0815316194]
xref: Wikipedia:Growth_cone
is_a: GO:0030427 ! site of polarized growth
relationship: part_of GO:0043005 ! neuron projection

[Term]
id: GO:0030427
name: site of polarized growth
namespace: cellular_component
alt_id: GO:0000134
alt_id: GO:0030483
def: "Any part of a cell where non-isotropic growth takes place." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030428
name: cell septum
namespace: cellular_component
def: "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:clt, ISBN:0471940526]
subset: goslim_pir
subset: gosubset_prok
synonym: "cross wall" EXACT []
synonym: "septum" BROAD []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030429
name: kynureninase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine." [EC:3.7.1.3]
subset: gosubset_prok
synonym: "kynurenine hydrolase activity" EXACT [EC:3.7.1.3]
synonym: "L-kynurenine hydrolase activity" EXACT [EC:3.7.1.3]
synonym: "l-kynurenine hydrolase activity" EXACT [EC:3.7.1.3]
xref: EC:3.7.1.3
xref: MetaCyc:KYNURENINASE-RXN
xref: Reactome:23316 "kynureninase activity"
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0030430
name: host cell cytoplasm
namespace: cellular_component
def: "The cytoplasm of a host cell." [GOC:mah]
subset: gosubset_prok
is_a: GO:0033646 ! host intracellular part

[Term]
id: GO:0030431
name: sleep
namespace: biological_process
def: "Any process by which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]
subset: goslim_pir
synonym: "diapause" RELATED []
synonym: "dormancy" RELATED []
synonym: "lethargus" RELATED []
xref: Wikipedia:Sleep
is_a: GO:0007610 ! behavior
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0030432
name: peristalsis
namespace: biological_process
def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: Wikipedia:Peristalsis
is_a: GO:0014821 ! phasic smooth muscle contraction

[Term]
id: GO:0030433
name: ER-associated protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation." [GOC:mah, GOC:rb, PMID:14607247]
comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
synonym: "endoplasmic reticulum-associated protein catabolic process" EXACT []
synonym: "endoplasmic reticulum-associated protein catabolism" EXACT []
synonym: "ER-associated protein breakdown" EXACT []
synonym: "ER-associated protein catabolism" EXACT []
synonym: "ER-associated protein degradation" EXACT []
synonym: "ERAD" EXACT []
is_a: GO:0006515 ! misfolded or incompletely synthesized protein catabolic process
is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0071218 ! cellular response to misfolded protein

[Term]
id: GO:0030435
name: sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "The process by which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:mah, GOC:pamgo_08, ISBN:0072992913]
comment: Note that the synonym 'spore differentiation', like the term name and definition, refers to differentiation into a spore rather than any subsequent developmental changes that a spore may undergo.
subset: goslim_yeast
subset: gosubset_prok
synonym: "cellular spore formation by sporulation" EXACT [GOC:dph, GOC:tb]
synonym: "spore biosynthesis" EXACT []
synonym: "spore differentiation" EXACT []
synonym: "spore formation" EXACT []
xref: Wikipedia:Sporogenesis
is_a: GO:0030154 ! cell differentiation
is_a: GO:0043934 ! sporulation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0030436
name: asexual sporulation
namespace: biological_process
def: "The formation of spores derived from the products of mitosis. Examples of this process are found in Bacterial species." [GOC:mah, PMID:9529886]
subset: gosubset_prok
synonym: "asexual spore formation" EXACT []
synonym: "mitotic spore formation" EXACT []
synonym: "mitotic sporulation" EXACT []
is_a: GO:0019954 ! asexual reproduction
is_a: GO:0043934 ! sporulation

[Term]
id: GO:0030437
name: ascospore formation
namespace: biological_process
alt_id: GO:0007151
def: "The process whereby cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota)." [GOC:mah, PMID:16339736]
subset: goslim_pombe
synonym: "ascospore biosynthesis" EXACT []
synonym: "spore formation" BROAD []
synonym: "sporulation" BROAD []
is_a: GO:0022413 ! reproductive process in single-celled organism
is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore
is_a: GO:0048468 ! cell development

[Term]
id: GO:0030438
name: MAPKKK cascade during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0030439
name: activation of MAPK during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0030440
name: activation of MAPKK during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0030441
name: activation of MAPKKK during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0030442
name: inactivation of MAPK during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0030443
name: nuclear translocation of MAPK during sporulation (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true

[Term]
id: GO:0030444
name: microtubule depolymerization during nuclear congression
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because the entire branch of the ontology was changed.
is_obsolete: true
replaced_by: GO:0007019

[Term]
id: GO:0030445
name: yeast-form cell wall
namespace: cellular_component
def: "The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form." [GOC:mah, GOC:mcc]
comment: See also the Fungal Anatomy Ontology term 'vegetative cell ; FAO:0000032'.
is_a: GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0030446
name: hyphal cell wall
namespace: cellular_component
def: "The cell wall surrounding a fungal hypha." [GOC:mah]
comment: See also the Fungal Anatomy Ontology term 'hypha ; FAO:0001001'.
is_a: GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0030447
name: filamentous growth
namespace: biological_process
def: "The process by which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mcc, PMID:11729141]
subset: goslim_candida
is_a: GO:0040007 ! growth

[Term]
id: GO:0030448
name: hyphal growth
namespace: biological_process
def: "Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls." [GOC:mcc, ISBN:0471522295]
subset: goslim_candida
is_a: GO:0030447 ! filamentous growth

[Term]
id: GO:0030449
name: regulation of complement activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of complement activation." [GOC:go_curators]
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0002920 ! regulation of humoral immune response
is_a: GO:0010953 ! regulation of protein maturation by peptide bond cleavage
relationship: regulates GO:0006956 ! complement activation

[Term]
id: GO:0030450
name: regulation of complement activation, classical pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the classical pathway of complement activation." [GOC:go_curators]
is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin
is_a: GO:0030449 ! regulation of complement activation
relationship: regulates GO:0006958 ! complement activation, classical pathway

[Term]
id: GO:0030451
name: regulation of complement activation, alternative pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation." [GOC:go_curators]
is_a: GO:0030449 ! regulation of complement activation
is_a: GO:0045088 ! regulation of innate immune response
relationship: regulates GO:0006957 ! complement activation, alternative pathway

[Term]
id: GO:0030455
name: MAPKKK cascade (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE. MAPKKK cascade involved in transducing mating pheromone signal in a fungus." [GOC:mah]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030456
name: activation of MAPK (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030457
name: activation of MAPKK (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030458
name: activation of MAPKKK (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030459
name: inactivation of MAPK (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030460
name: nuclear translocation of MAPK (mating sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh]
comment: This term was made obsolete because it is a gene product specific term.
is_obsolete: true
replaced_by: GO:0000750

[Term]
id: GO:0030463
name: cell aging (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'.
is_obsolete: true
replaced_by: GO:0007569

[Term]
id: GO:0030464
name: aging dependent sterility (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:sgd_curators]
comment: This term was made obsolete because it reflected a trait or phenotype.
is_obsolete: true
consider: GO:0030466

[Term]
id: GO:0030465
name: autophagic death (sensu Fungi)
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because a more correct term has been created.
is_obsolete: true
consider: GO:0048102

[Term]
id: GO:0030466
name: chromatin silencing at silent mating-type cassette
namespace: biological_process
alt_id: GO:0006347
def: "Repression of transcription at silent mating-type loci by alteration of the structure of chromatin." [GOC:mcc]
synonym: "aging-dependent sterility" NARROW []
synonym: "chromatin silencing at HML and HMR" NARROW []
synonym: "heterochromatic silencing at silent mating-type cassette" EXACT []
is_a: GO:0006342 ! chromatin silencing

[Term]
id: GO:0030470
name: spore germination (sensu Fungi)
namespace: biological_process
alt_id: GO:0007153
def: "OBSOLETE. Process of breakdown or opening of the spore-containing structure, modification of the spore wall, and resumption of growth of the spore. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [GOC:mcc]
comment: This term was made obsolete because a sensu term was not needed.
synonym: "germination (sensu Saccharomyces)" NARROW []
is_obsolete: true
replaced_by: GO:0009847

[Term]
id: GO:0030471
name: spindle pole body and microtubule cycle (sensu Fungi)
namespace: biological_process
alt_id: GO:0007102
def: "OBSOLETE. The dynamics of the spindle pole body and microtubule cytoskeleton during the cell cycle. Includes spindle pole body duplication and separation and formation and elongation of the mitotic spindle. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [ISBN:0879693649]
comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity.
synonym: "spindle pole body and microtubule cycle (sensu Saccharomyces)" NARROW []
is_obsolete: true
consider: GO:0007051
consider: GO:0051300

[Term]
id: GO:0030472
name: mitotic spindle organization in nucleus
namespace: biological_process
alt_id: GO:0000071
def: "A process resulting in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle in the nucleus. The process occurs during a mitotic cell cycle and takes place at the cellular level." [GOC:mah]
synonym: "mitotic spindle assembly" BROAD []
synonym: "mitotic spindle organisation in nucleus" EXACT []
synonym: "mitotic spindle organization and biogenesis in cell nucleus" EXACT []
synonym: "mitotic spindle organization and biogenesis in nucleus" EXACT []
synonym: "spindle organization and biogenesis in nucleus during mitosis" EXACT []
is_a: GO:0007052 ! mitotic spindle organization

[Term]
id: GO:0030473
name: nuclear migration along microtubule
namespace: biological_process
alt_id: GO:0000065
def: "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators]
synonym: "microtubule cytoskeleton-dependent nuclear positioning" EXACT []
synonym: "microtubule cytoskeleton-dependent nucleus positioning" EXACT []
synonym: "microtubule-dependent nuclear positioning" EXACT []
synonym: "microtubule-dependent nucleus positioning" EXACT []
synonym: "microtubule-mediated nuclear migration" EXACT []
synonym: "nuclear migration, microtubule-mediated" EXACT []
synonym: "nuclear movement, microtubule-mediated" BROAD []
synonym: "nucleus migration" BROAD []
synonym: "transport of nucleus by microtubules" EXACT []
synonym: "transport of nucleus, microtubule-mediated" EXACT []
is_a: GO:0007097 ! nuclear migration
is_a: GO:0010970 ! microtubule-based transport

[Term]
id: GO:0030474
name: spindle pole body duplication
namespace: biological_process
def: "Construction of a new spindle pole body." [GOC:clt]
synonym: "spindle pole body assembly" EXACT []
synonym: "spindle pole body biogenesis" EXACT []
synonym: "spindle pole body biosynthesis" EXACT []
synonym: "spindle pole body formation" EXACT []
synonym: "spindle pole body replication" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0051300 ! spindle pole body organization

[Term]
id: GO:0030476
name: ascospore wall assembly
namespace: biological_process
alt_id: GO:0007152
def: "The process by which the ascospore nucleus becomes surrounded by a specialized spore wall. Occurs by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:14702385]
synonym: "spore wall assembly" BROAD []
is_a: GO:0042244 ! spore wall assembly
relationship: part_of GO:0070591 ! ascospore wall biogenesis

[Term]
id: GO:0030478
name: actin cap
namespace: cellular_component
alt_id: GO:0000143
def: "Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae." [GOC:mah, ISBN:10652251]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0030479
name: actin cortical patch
namespace: cellular_component
alt_id: GO:0005857
def: "A discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae." [GOC:mah, GOC:vw, ISBN:0879693568, ISBN:0879693649, PMID:16959963]
synonym: "actin patch" EXACT []
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0030484
name: muscle fiber
namespace: cellular_component
def: "OBSOLETE. The contractile fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:mah, ISBN:0815316194]
comment: This term was made obsolete because a muscle fiber is a cell type rather than a cell component. To update annotations, consider the external ontology term 'muscle cell ; CL:0000187'.
synonym: "muscle fibre" EXACT []
is_obsolete: true
consider: GO:0043292

[Term]
id: GO:0030485
name: smooth muscle contractile fiber
namespace: cellular_component
def: "The contractile fiber of smooth muscle cells." [GOC:mah]
synonym: "smooth muscle fiber" BROAD []
synonym: "smooth muscle fibre" EXACT []
is_a: GO:0043292 ! contractile fiber
is_a: GO:0044449 ! contractile fiber part

[Term]
id: GO:0030486
name: smooth muscle dense body
namespace: cellular_component
def: "Electron-dense region associated with a smooth muscle contractile fiber." [GOC:mah, ISBN:0815316194]
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030485 ! smooth muscle contractile fiber

[Term]
id: GO:0030487
name: inositol-4,5-bisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the removal of a phosphate group from the carbon-5 position of D-myo-inositol 4,5-bisphosphate." [GOC:mah]
is_a: GO:0016312 ! inositol bisphosphate phosphatase activity

[Term]
id: GO:0030488
name: tRNA methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001510 ! RNA methylation
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0030489
name: processing of 27S pre-rRNA
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:curators]
comment: This term was made obsolete because it was not defined and did not correspond to the production of a single specific mature rRNA product.
is_obsolete: true

[Term]
id: GO:0030490
name: maturation of SSU-rRNA
namespace: biological_process
def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators]
synonym: "processing of 20S pre-rRNA" NARROW []
is_a: GO:0006364 ! rRNA processing

[Term]
id: GO:0030491
name: heteroduplex formation
namespace: biological_process
def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:10357855]
xref: Reactome:76007 "Heteroduplex formation"
xref: Reactome:76008 "Synaptic stable pairing/D-loop structure formation between recombining DNA molecules"
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0030492
name: hemoglobin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:jl, http://cancerweb.ncl.ac.uk/]
synonym: "globin binding" NARROW []
synonym: "haemoglobin binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030493
name: bacteriochlorophyll metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "bacteriochlorophyll metabolism" EXACT []
is_a: GO:0015994 ! chlorophyll metabolic process

[Term]
id: GO:0030494
name: bacteriochlorophyll biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "bacteriochlorophyll anabolism" EXACT []
synonym: "bacteriochlorophyll biosynthesis" EXACT []
synonym: "bacteriochlorophyll formation" EXACT []
synonym: "bacteriochlorophyll synthesis" EXACT []
is_a: GO:0015995 ! chlorophyll biosynthetic process
is_a: GO:0030493 ! bacteriochlorophyll metabolic process

[Term]
id: GO:0030495
name: bacteriochlorophyll catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:go_curators]
subset: gosubset_prok
synonym: "bacteriochlorophyll breakdown" EXACT []
synonym: "bacteriochlorophyll catabolism" EXACT []
synonym: "bacteriochlorophyll degradation" EXACT []
is_a: GO:0015996 ! chlorophyll catabolic process
is_a: GO:0030493 ! bacteriochlorophyll metabolic process

[Term]
id: GO:0030496
name: midbody
namespace: cellular_component
def: "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]
subset: goslim_pir
xref: Wikipedia:Midbody_(cell_biology)
is_a: GO:0044464 ! cell part

[Term]
id: GO:0030497
name: fatty acid elongation
namespace: biological_process
def: "The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094]
subset: gosubset_prok
is_a: GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0030500
name: regulation of bone mineralization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone mineralization." [GOC:go_curators]
is_a: GO:0030278 ! regulation of ossification
is_a: GO:0070167 ! regulation of biomineral formation
relationship: regulates GO:0030282 ! bone mineralization

[Term]
id: GO:0030501
name: positive regulation of bone mineralization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone mineralization." [GOC:go_curators]
synonym: "activation of bone mineralization" NARROW []
synonym: "stimulation of bone mineralization" NARROW []
synonym: "up regulation of bone mineralization" EXACT []
synonym: "up-regulation of bone mineralization" EXACT []
synonym: "upregulation of bone mineralization" EXACT []
is_a: GO:0030500 ! regulation of bone mineralization
is_a: GO:0045778 ! positive regulation of ossification
is_a: GO:0070169 ! positive regulation of biomineral formation
relationship: positively_regulates GO:0030282 ! bone mineralization

[Term]
id: GO:0030502
name: negative regulation of bone mineralization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization." [GOC:go_curators]
synonym: "down regulation of bone mineralization" EXACT []
synonym: "down-regulation of bone mineralization" EXACT []
synonym: "downregulation of bone mineralization" EXACT []
synonym: "inhibition of bone mineralization" NARROW []
is_a: GO:0030279 ! negative regulation of ossification
is_a: GO:0030500 ! regulation of bone mineralization
is_a: GO:0070168 ! negative regulation of biomineral formation
relationship: negatively_regulates GO:0030282 ! bone mineralization

[Term]
id: GO:0030504
name: inorganic diphosphate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of inorganic diphosphate across a membrane." [PMID:11326272]
synonym: "inorganic pyrophosphate transporter activity" EXACT []
is_a: GO:0015103 ! inorganic anion transmembrane transporter activity

[Term]
id: GO:0030505
name: inorganic diphosphate transport
namespace: biological_process
def: "The directed movement of inorganic diphosphate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "inorganic pyrophosphate transport" EXACT []
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0030506
name: ankyrin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0030507
name: spectrin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0030508
name: thiol-disulfide exchange intermediate activity
namespace: molecular_function
def: "OBSOLETE. Functions as an exchange intermediate in thiol-disulfide exchange reactions." [GOC:kd, GOC:mah]
comment: This term was made obsolete because it represents a combination of gene product features and involvement in a biological process.
subset: gosubset_prok
synonym: "glutaredoxin" NARROW []
synonym: "thiol-disulphide exchange intermediate activity" EXACT []
synonym: "thioredoxin" NARROW []
is_obsolete: true
consider: GO:0006467
consider: GO:0015036

[Term]
id: GO:0030509
name: BMP signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor." [ISBN:0878932437]
synonym: "BMP receptor signaling pathway" RELATED []
synonym: "BMP signalling pathway" EXACT []
synonym: "bone morphogenetic protein signaling pathway" EXACT []
synonym: "bone morphogenetic protein signalling pathway" EXACT []
xref: Reactome:201451 "Signaling by BMP"
xref: Reactome:448668 "Signaling by BMP"
xref: Reactome:469796 "Signaling by BMP"
xref: Reactome:487490 "Signaling by BMP"
xref: Reactome:507450 "Signaling by BMP"
xref: Reactome:517448 "Signaling by BMP"
xref: Reactome:526322 "Signaling by BMP"
is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0030510
name: regulation of BMP signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah]
synonym: "regulation of BMP receptor signaling pathway" RELATED []
synonym: "regulation of BMP signalling pathway" EXACT []
synonym: "regulation of bone morphogenetic protein signaling pathway" EXACT []
synonym: "regulation of bone morphogenetic protein signalling pathway" EXACT []
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: regulates GO:0030509 ! BMP signaling pathway

[Term]
id: GO:0030511
name: positive regulation of transforming growth factor beta receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity." [GOC:go_curators]
synonym: "activation of transforming growth factor beta receptor signaling pathway" NARROW []
synonym: "positive regulation of TGF-beta receptor signaling pathway" EXACT []
synonym: "positive regulation of TGFbeta receptor signaling pathway" EXACT []
synonym: "positive regulation of transforming growth factor beta receptor signalling pathway" EXACT []
synonym: "stimulation of transforming growth factor beta receptor signaling pathway" NARROW []
synonym: "up regulation of transforming growth factor beta receptor signaling pathway" EXACT []
synonym: "up-regulation of transforming growth factor beta receptor signaling pathway" EXACT []
synonym: "upregulation of transforming growth factor beta receptor signaling pathway" EXACT []
is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: positively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway

[Term]
id: GO:0030512
name: negative regulation of transforming growth factor beta receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway." [GOC:mah]
synonym: "down regulation of transforming growth factor beta receptor signaling pathway" EXACT []
synonym: "down-regulation of transforming growth factor beta receptor signaling pathway" EXACT []
synonym: "downregulation of transforming growth factor beta receptor signaling pathway" EXACT []
synonym: "inhibition of transforming growth factor beta receptor signaling pathway" NARROW []
synonym: "negative regulation of TGF-beta receptor signaling pathway" EXACT []
synonym: "negative regulation of TGFbeta receptor signaling pathway" EXACT []
synonym: "negative regulation of transforming growth factor beta receptor signalling pathway" EXACT []
xref: Reactome:173481 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling"
xref: Reactome:173512 "I-SMAD competes with R-SMAD for type I receptor"
xref: Reactome:440508 "I-SMAD competes with R-SMAD for type I receptor"
xref: Reactome:446771 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling"
xref: Reactome:462291 "I-SMAD competes with R-SMAD for type I receptor"
xref: Reactome:468103 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling"
xref: Reactome:501111 "I-SMAD competes with R-SMAD for type I receptor"
xref: Reactome:505863 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling"
xref: Reactome:516560 "SKI complexes with the SMAD complex, suppressing TGF-beta signaling"
is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: negatively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway

[Term]
id: GO:0030513
name: positive regulation of BMP signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators]
synonym: "activation of BMP signaling pathway" NARROW []
synonym: "positive regulation of BMP receptor signaling pathway" RELATED []
synonym: "positive regulation of BMP signalling pathway" EXACT []
synonym: "positive regulation of bone morphogenetic protein signaling pathway" EXACT []
synonym: "positive regulation of bone morphogenetic protein signalling pathway" EXACT []
synonym: "stimulation of BMP signaling pathway" NARROW []
synonym: "up regulation of BMP signaling pathway" EXACT []
synonym: "up-regulation of BMP signaling pathway" EXACT []
synonym: "upregulation of BMP signaling pathway" EXACT []
is_a: GO:0030510 ! regulation of BMP signaling pathway
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: positively_regulates GO:0030509 ! BMP signaling pathway

[Term]
id: GO:0030514
name: negative regulation of BMP signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators]
synonym: "down regulation of BMP signaling pathway" EXACT []
synonym: "down-regulation of BMP signaling pathway" EXACT []
synonym: "downregulation of BMP signaling pathway" EXACT []
synonym: "inhibition of BMP signaling pathway" NARROW []
synonym: "negative regulation of BMP receptor signaling pathway" RELATED []
synonym: "negative regulation of BMP signalling pathway" EXACT []
synonym: "negative regulation of bone morphogenetic protein signaling pathway" EXACT []
synonym: "negative regulation of bone morphogenetic protein signalling pathway" EXACT []
is_a: GO:0030510 ! regulation of BMP signaling pathway
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: negatively_regulates GO:0030509 ! BMP signaling pathway

[Term]
id: GO:0030515
name: snoRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with small nucleolar RNA." [GOC:mah]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0030516
name: regulation of axon extension
namespace: biological_process
def: "Any process that modulates the rate, direction or extent of axon extension." [GOC:go_curators]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0050770 ! regulation of axonogenesis
relationship: regulates GO:0048675 ! axon extension

[Term]
id: GO:0030517
name: negative regulation of axon extension
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of axon outgrowth." [GOC:mah]
synonym: "down regulation of axon extension" EXACT []
synonym: "down-regulation of axon extension" EXACT []
synonym: "downregulation of axon extension" EXACT []
synonym: "inhibition of axon extension" NARROW []
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0030516 ! regulation of axon extension
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0050771 ! negative regulation of axonogenesis
relationship: negatively_regulates GO:0048675 ! axon extension

[Term]
id: GO:0030518
name: steroid hormone receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of a steroid hormone binding to its receptor." [GOC:mah]
synonym: "steroid hormone receptor signalling pathway" EXACT []
is_a: GO:0030522 ! intracellular receptor-mediated signaling pathway

[Term]
id: GO:0030519
name: snoRNP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of a small nucleolar ribonucleoprotein particle." [GOC:mah]
is_a: GO:0043021 ! ribonucleoprotein binding

[Term]
id: GO:0030520
name: estrogen receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of an estrogen binding to its receptor." [GOC:mah]
synonym: "estrogen receptor signalling pathway" EXACT []
is_a: GO:0030518 ! steroid hormone receptor signaling pathway

[Term]
id: GO:0030521
name: androgen receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of an androgen binding to its receptor." [GOC:mah]
synonym: "androgen receptor signalling pathway" EXACT []
is_a: GO:0030518 ! steroid hormone receptor signaling pathway

[Term]
id: GO:0030522
name: intracellular receptor-mediated signaling pathway
namespace: biological_process
def: "Any series of molecular signals initiated by a ligand entering the target cell, where it binds to an intracellular receptor." [GOC:mah]
synonym: "intracellular receptor-mediated signalling pathway" EXACT []
is_a: GO:0007242 ! intracellular signaling cascade

[Term]
id: GO:0030523
name: dihydrolipoamide S-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide." [EC:2.3.1.12, GOC:mah]
subset: gosubset_prok
is_a: GO:0016417 ! S-acyltransferase activity

[Term]
id: GO:0030526
name: granulocyte macrophage colony-stimulating factor receptor complex
namespace: cellular_component
def: "The heterodimeric receptor for granulocyte macrophage colony-stimulating factor." [GOC:mah]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0030527
name: structural constituent of chromatin
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0030528
name: transcription regulator activity
namespace: molecular_function
def: "Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:mah]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "transcriptional regulator activity" EXACT []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0030529
name: ribonucleoprotein complex
namespace: cellular_component
def: "A macromolecular complex containing both protein and RNA molecules." [GOC:krc]
subset: goslim_pir
subset: gosubset_prok
synonym: "protein-RNA complex" EXACT []
synonym: "ribonucleoprotein" EXACT []
synonym: "RNA-protein complex" EXACT []
synonym: "RNP" EXACT []
xref: Wikipedia:Ribonucleoprotein
is_a: GO:0032991 ! macromolecular complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0030530
name: heterogeneous nuclear ribonucleoprotein complex
namespace: cellular_component
def: "Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "heterogeneous nuclear ribonucleoprotein" EXACT []
synonym: "hnRNP" EXACT []
xref: Wikipedia:Heterogeneous_ribonucleoprotein_particle
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0030531
name: small cytoplasmic ribonucleoprotein complex
namespace: cellular_component
def: "A complex composed of RNA of the small cytoplasmic RNA (scRNA) class and protein, found in the cytoplasm." [GOC:krc, GOC:mah]
synonym: "scRNP" EXACT []
synonym: "small cytoplasmic ribonucleoprotein" EXACT []
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0030532
name: small nuclear ribonucleoprotein complex
namespace: cellular_component
def: "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]
subset: goslim_pir
synonym: "small nuclear ribonucleoprotein" EXACT []
synonym: "snRNP" EXACT []
xref: Wikipedia:SnRNP
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0030533
name: triplet codon-amino acid adaptor activity
namespace: molecular_function
def: "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis." [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'.
subset: goslim_candida
subset: goslim_generic
subset: goslim_yeast
synonym: "transfer RNA" RELATED []
synonym: "tRNA" RELATED []
is_a: GO:0000499 ! base pairing with mRNA
is_a: GO:0060090 ! molecular adaptor activity

[Term]
id: GO:0030534
name: adult behavior
namespace: biological_process
def: "Behavior in a fully developed and mature organism." [GOC:mah, ISBN:0877797099]
comment: See also the biological process term 'behavior ; GO:0007610'.
synonym: "adult behavioral response to stimulus" EXACT []
synonym: "adult behaviour" EXACT []
synonym: "adult behavioural response to stimulus" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0030535
name: adult feeding behavior (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. Feeding behavior in a fully developed and mature organism, as described in insects." [GOC:go_curators, GOC:jic]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
is_obsolete: true
replaced_by: GO:0008343

[Term]
id: GO:0030536
name: larval feeding behavior
namespace: biological_process
def: "Feeding behavior in a larval (immature) organism." [GOC:mah]
comment: See also the biological process term 'feeding behavior ; GO:0007631'.
synonym: "larval feeding behaviour" EXACT []
is_a: GO:0007631 ! feeding behavior
is_a: GO:0030537 ! larval behavior

[Term]
id: GO:0030537
name: larval behavior
namespace: biological_process
alt_id: GO:0017037
def: "Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics." [GOC:mah, ISBN:0877797099]
comment: See also the biological process term 'behavior ; GO:0007610'.
synonym: "larval behaviour" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0030538
name: embryonic genitalia morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized. Morphogenesis pertains to the creation of form." [GOC:bf]
synonym: "embryonic genital morphogenesis" RELATED []
is_a: GO:0035112 ! genitalia morphogenesis
is_a: GO:0048562 ! embryonic organ morphogenesis

[Term]
id: GO:0030539
name: male genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure." [GOC:ems, ISBN:0140512888]
synonym: "male genital development" EXACT []
is_a: GO:0048806 ! genitalia development
relationship: part_of GO:0046546 ! development of primary male sexual characteristics

[Term]
id: GO:0030540
name: female genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure." [GOC:mah]
synonym: "female genital development" EXACT []
is_a: GO:0048806 ! genitalia development
relationship: part_of GO:0046545 ! development of primary female sexual characteristics

[Term]
id: GO:0030541
name: plasmid partitioning
namespace: biological_process
alt_id: GO:0030542
def: "Any process by which plasmids are segregated or distributed into daughter cells upon cell division." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006276 ! plasmid maintenance

[Term]
id: GO:0030543
name: 2-micrometer plasmid partitioning
namespace: biological_process
def: "The process by which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division." [GOC:mah]
is_a: GO:0030541 ! plasmid partitioning

[Term]
id: GO:0030544
name: Hsp70 protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0031072 ! heat shock protein binding

[Term]
id: GO:0030545
name: receptor regulator activity
namespace: molecular_function
def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed." [GOC:ceb]
is_a: GO:0005057 ! receptor signaling protein activity

[Term]
id: GO:0030546
name: receptor activator activity
namespace: molecular_function
def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb]
is_a: GO:0030545 ! receptor regulator activity

[Term]
id: GO:0030547
name: receptor inhibitor activity
namespace: molecular_function
def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased." [GOC:ceb]
is_a: GO:0030545 ! receptor regulator activity

[Term]
id: GO:0030548
name: acetylcholine receptor regulator activity
namespace: molecular_function
def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed." [GOC:mah]
is_a: GO:0030545 ! receptor regulator activity

[Term]
id: GO:0030549
name: acetylcholine receptor activator activity
namespace: molecular_function
def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased." [GOC:mah]
is_a: GO:0030546 ! receptor activator activity
is_a: GO:0030548 ! acetylcholine receptor regulator activity

[Term]
id: GO:0030550
name: acetylcholine receptor inhibitor activity
namespace: molecular_function
def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is decreased." [GOC:mah]
is_a: GO:0030547 ! receptor inhibitor activity
is_a: GO:0030548 ! acetylcholine receptor regulator activity

[Term]
id: GO:0030551
name: cyclic nucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:ai]
subset: gosubset_prok
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0030552
name: cAMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)." [GOC:ai]
subset: gosubset_prok
synonym: "3',5' cAMP binding" EXACT []
synonym: "3',5'-cAMP binding" EXACT []
synonym: "adenosine 3',5'-cyclophosphate binding" EXACT []
synonym: "cyclic AMP binding" EXACT []
is_a: GO:0016208 ! AMP binding
is_a: GO:0030551 ! cyclic nucleotide binding

[Term]
id: GO:0030553
name: cGMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai]
synonym: "3',5' cGMP binding" EXACT []
synonym: "3',5'-cGMP binding" EXACT []
synonym: "cyclic GMP binding" EXACT []
is_a: GO:0019002 ! GMP binding
is_a: GO:0030551 ! cyclic nucleotide binding

[Term]
id: GO:0030554
name: adenyl nucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0001883 ! purine nucleoside binding
is_a: GO:0017076 ! purine nucleotide binding

[Term]
id: GO:0030555
name: RNA modification guide activity
namespace: molecular_function
def: "Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0000498 ! base pairing with RNA

[Term]
id: GO:0030556
name: rRNA modification guide activity
namespace: molecular_function
def: "Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0000944 ! base pairing with rRNA
is_a: GO:0030555 ! RNA modification guide activity

[Term]
id: GO:0030557
name: tRNA modification guide activity
namespace: molecular_function
def: "Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0000946 ! base pairing with tRNA
is_a: GO:0030555 ! RNA modification guide activity

[Term]
id: GO:0030558
name: RNA pseudouridylation guide activity
namespace: molecular_function
def: "Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030555 ! RNA modification guide activity

[Term]
id: GO:0030559
name: rRNA pseudouridylation guide activity
namespace: molecular_function
def: "Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030556 ! rRNA modification guide activity
is_a: GO:0030558 ! RNA pseudouridylation guide activity

[Term]
id: GO:0030560
name: tRNA pseudouridylation guide activity
namespace: molecular_function
def: "Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030557 ! tRNA modification guide activity
is_a: GO:0030558 ! RNA pseudouridylation guide activity

[Term]
id: GO:0030561
name: RNA 2'-O-ribose methylation guide activity
namespace: molecular_function
def: "Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030555 ! RNA modification guide activity

[Term]
id: GO:0030562
name: rRNA 2'-O-ribose methylation guide activity
namespace: molecular_function
def: "Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030556 ! rRNA modification guide activity
is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity

[Term]
id: GO:0030563
name: snRNA 2'-O-ribose methylation guide activity
namespace: molecular_function
def: "Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule." [PMID:11733745]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs.
is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity
is_a: GO:0030566 ! snRNA modification guide activity

[Term]
id: GO:0030564
name: tRNA 2'-O-ribose methylation guide activity
namespace: molecular_function
def: "Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0030557 ! tRNA modification guide activity
is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity

[Term]
id: GO:0030565
name: snRNA pseudouridylation guide activity
namespace: molecular_function
def: "Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule." [PMID:11733745]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs.
is_a: GO:0030558 ! RNA pseudouridylation guide activity
is_a: GO:0030566 ! snRNA modification guide activity

[Term]
id: GO:0030566
name: snRNA modification guide activity
namespace: molecular_function
def: "Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]
comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins.
is_a: GO:0000945 ! base pairing with snRNA
is_a: GO:0030555 ! RNA modification guide activity

[Term]
id: GO:0030567
name: thrombin activator activity
namespace: molecular_function
def: "OBSOLETE. Increases the rate of proteolysis catalyzed by thrombin." [GOC:mah]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
subset: gosubset_prok
synonym: "prothrombin activator activity" RELATED [GOC:dph, GOC:tb]
is_obsolete: true
replaced_by: GO:0016504

[Term]
id: GO:0030568
name: plasmin inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase plasmin." [GOC:mah]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function.
is_obsolete: true
replaced_by: GO:0004867

[Term]
id: GO:0030569
name: chymotrypsin inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase chymotrypsin." [GOC:mah]
comment: This term was made obsolete because it represents a regulator of an obsolete molecular function term.
is_obsolete: true
replaced_by: GO:0004867

[Term]
id: GO:0030570
name: pectate lyase activity
namespace: molecular_function
def: "Catalysis of the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends." [EC:4.2.2.2]
subset: gosubset_prok
synonym: "(1->4)-alpha-D-galacturonan lyase activity" EXACT [EC:4.2.2.2]
synonym: "alpha-1,4-D-endopolygalacturonic acid lyase activity" EXACT [EC:4.2.2.2]
synonym: "endo-alpha-1,4-polygalacturonic acid lyase activity" EXACT [EC:4.2.2.2]
synonym: "endogalacturonate transeliminase activity" EXACT [EC:4.2.2.2]
synonym: "endopectin methyltranseliminase activity" EXACT [EC:4.2.2.2]
synonym: "pectate transeliminase activity" EXACT [EC:4.2.2.2]
synonym: "pectic acid lyase activity" EXACT [EC:4.2.2.2]
synonym: "pectic acid transeliminase activity" EXACT [EC:4.2.2.2]
synonym: "pectic lyase activity" BROAD [EC:4.2.2.2]
synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.2]
synonym: "PGA lyase activity" EXACT [EC:4.2.2.2]
synonym: "polygalacturonate lyase activity" EXACT [EC:4.2.2.2]
synonym: "polygalacturonic acid lyase activity" EXACT [EC:4.2.2.2]
synonym: "polygalacturonic acid trans-eliminase activity" EXACT [EC:4.2.2.2]
synonym: "polygalacturonic transeliminase activity" EXACT [EC:4.2.2.2]
synonym: "PPase-N activity" EXACT [EC:4.2.2.2]
xref: EC:4.2.2.2
xref: MetaCyc:4.2.2.2-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0030572
name: phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) moiety." [GOC:mb]
subset: gosubset_prok
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0030573
name: bile acid catabolic process
namespace: biological_process
alt_id: GO:0019613
def: "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators]
synonym: "bile acid 7alpha-dehydroxylation pathway" NARROW []
synonym: "bile acid breakdown" EXACT []
synonym: "bile acid catabolism" EXACT []
synonym: "bile acid degradation" EXACT []
synonym: "cholate catabolic process" NARROW []
xref: MetaCyc:7ALPHADEHYDROX-PWY
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0008206 ! bile acid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0030574
name: collagen catabolic process
namespace: biological_process
def: "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]
synonym: "collagen breakdown" EXACT []
synonym: "collagen catabolism" EXACT []
synonym: "collagen degradation" EXACT []
is_a: GO:0032963 ! collagen metabolic process
is_a: GO:0044243 ! multicellular organismal catabolic process

[Term]
id: GO:0030575
name: nuclear body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:dph, GOC:jl, GOC:mah]
synonym: "nuclear body organisation" EXACT [GOC:curators]
synonym: "nuclear body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006997 ! nucleus organization

[Term]
id: GO:0030576
name: Cajal body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238]
comment: See also the cellular component term 'Cajal body ; GO:0015030'.
synonym: "Cajal body organisation" EXACT [GOC:curators]
synonym: "Cajal body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030575 ! nuclear body organization

[Term]
id: GO:0030577
name: Lands organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Lands, a class of nuclear body that react against SP140 auto-antibodies." [GOC:mah, PMID:10921892, PMID:8695863]
comment: See also the cellular component term 'Lands ; GO:0016606'.
synonym: "Lands organisation" EXACT [GOC:curators]
synonym: "Lands organization and biogenesis" RELATED [GOC:mah]
synonym: "LYSP100-associated nuclear domain organization" EXACT [GOC:mah]
is_a: GO:0030575 ! nuclear body organization

[Term]
id: GO:0030578
name: PML body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia)." [GOC:mah, PMID:10806078]
comment: See also the cellular component term 'PML body ; GO:0016605'.
synonym: "PML body organisation" EXACT [GOC:curators]
synonym: "PML body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030575 ! nuclear body organization

[Term]
id: GO:0030579
name: ubiquitin-dependent SMAD protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome." [GOC:go_curators]
synonym: "ubiquitin-dependent SMAD protein breakdown" EXACT []
synonym: "ubiquitin-dependent SMAD protein catabolism" EXACT []
synonym: "ubiquitin-dependent SMAD protein degradation" EXACT []
is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process
relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0030580
name: quinone cofactor methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1)." [GOC:mb]
subset: gosubset_prok
is_a: GO:0008169 ! C-methyltransferase activity

[Term]
id: GO:0030581
name: symbiont intracellular protein transport in host
namespace: biological_process
def: "The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb]
synonym: "host cell protein transport" EXACT []
synonym: "intracellular protein transport in host" EXACT []
is_a: GO:0051701 ! interaction with host
is_a: GO:0051708 ! intracellular protein transport in other organism during symbiotic interaction

[Term]
id: GO:0030582
name: fruiting body development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fruiting body over time, from its formation to the mature structure. A fruiting body is a multicellular structure that contains spores." [GOC:mah, GOC:mtg_sensu]
synonym: "fruiting body formation" EXACT []
is_a: GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0030583
name: fruiting body development in cellular response to starvation
namespace: biological_process
def: "The process whose specific outcome is the progression of the fruiting body over time, from its formation to the mature structure. The process begins when cells respond to a lack of nutrients in the environment and ends when the fruiting body is a mature structure." [GOC:mtg_sensu, ISBN:0815316194, PMID:11121786]
comment: For example, as seen in myxobacterium and Dictyostelium.
subset: gosubset_prok
is_a: GO:0009267 ! cellular response to starvation
is_a: GO:0048869 ! cellular developmental process
is_a: GO:0055084 ! fruiting body development in response to starvation

[Term]
id: GO:0030584
name: sporocarp development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sporocarp over time, from its formation to the mature structure. The sporocarp is a spore bearing fruiting body organ. An example of this process is found in the Fungal species Coprinopsis cinerea." [GOC:mah, GOC:mtg_sensu]
synonym: "fruiting body development" BROAD []
is_a: GO:0030582 ! fruiting body development

[Term]
id: GO:0030585
name: phosphoenolpyruvate carboxykinase (diphosphate) activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + oxaloacetate = phosphate + phosphoenolpyruvate + CO2." [EC:4.1.1.38]
synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.38]
synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.38]
synonym: "PEP carboxyphosphotransferase activity" EXACT [EC:4.1.1.38]
synonym: "PEPCTrP" RELATED [EC:4.1.1.38]
synonym: "phosphoenolpyruvate carboxykinase (pyrophosphate) activity" EXACT [EC:4.1.1.38]
synonym: "phosphoenolpyruvate carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38]
synonym: "phosphoenolpyruvate carboxyphosphotransferase activity" EXACT [EC:4.1.1.38]
synonym: "phosphoenolpyruvate carboxytransphosphorylase activity" EXACT [EC:4.1.1.38]
synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.38]
synonym: "phosphoenolpyruvic carboxykinase (pyrophosphate)" EXACT [EC:4.1.1.38]
synonym: "phosphoenolpyruvic carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38]
synonym: "phosphoenolpyruvic carboxytransphosphorylase activity" EXACT [EC:4.1.1.38]
synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.38]
synonym: "phosphopyruvate carboxykinase (pyrophosphate)" EXACT [EC:4.1.1.38]
synonym: "phosphopyruvate carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38]
xref: EC:4.1.1.38
xref: MetaCyc:4.1.1.38-RXN
is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity

[Term]
id: GO:0030586
name: [methionine synthase] reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+." [EC:1.16.1.8]
comment: Note that this was EC:2.1.1.135.
synonym: "5-methyltetrahydrofolate-homocysteine methyltransferase reductase" RELATED []
synonym: "[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity" EXACT []
synonym: "methionine synthase cob(II)alamin reductase (methylating) activity" EXACT [EC:1.16.1.8]
synonym: "methionine synthase reductase activity" EXACT [EC:1.16.1.8]
synonym: "methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing)" EXACT [EC:1.16.1.8]
synonym: "methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.8]
xref: EC:1.16.1.8
xref: MetaCyc:2.1.1.135-RXN
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0030587
name: sorocarp development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum." [DDB_REF:2530 "DictyBase paper repository", GOC:mah, GOC:mtg_sensu, ISBN:0521583640]
synonym: "fruiting body development" BROAD []
synonym: "fruiting body formation" BROAD []
synonym: "sorocarp biosynthesis" EXACT []
synonym: "sorocarp formation" EXACT []
is_a: GO:0055084 ! fruiting body development in response to starvation
relationship: part_of GO:0019954 ! asexual reproduction

[Term]
id: GO:0030588
name: pseudocleavage
namespace: biological_process
def: "Partial constriction of the cytoplasm of an embryo to form a furrow that resembles a cleavage furrow but does not complete cytokinesis." [GOC:mah, PMID:10751167, PMID:7729583]
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0009790 ! embryonic development

[Term]
id: GO:0030589
name: pseudocleavage during syncytial blastoderm formation
namespace: biological_process
def: "Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos in the syncytial blastoderm stage. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
is_a: GO:0030588 ! pseudocleavage
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0030590
name: pseudocleavage during first cell cycle
namespace: biological_process
def: "A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. An example of this process is found in nematode worms." [GOC:mtg_sensu, PMID:7729583]
is_a: GO:0030588 ! pseudocleavage

[Term]
id: GO:0030591
name: NAD DNA ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of the ADP-ribose moiety of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form." [PMID:11592983]
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0030592
name: DNA ADP-ribosylation
namespace: biological_process
def: "The covalent attachment of an ADP-ribosyl moiety to the amino group at N2 of a 2'-deoxyguanosine residue in double-stranded DNA." [PMID:11592983]
subset: gosubset_prok
is_a: GO:0006304 ! DNA modification

[Term]
id: GO:0030593
name: neutrophil chemotaxis
namespace: biological_process
def: "The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0030594
name: neurotransmitter receptor activity
namespace: molecular_function
def: "Combining with a neurotransmitter to initiate a change in cell activity." [GOC:jl]
is_a: GO:0004872 ! receptor activity
is_a: GO:0042165 ! neurotransmitter binding

[Term]
id: GO:0030595
name: leukocyte chemotaxis
namespace: biological_process
def: "The movement of a leukocyte in response to an external stimulus." [GOC:add, GOC:jl]
synonym: "immune cell chemotaxis" EXACT []
synonym: "leucocyte chemotaxis" EXACT []
is_a: GO:0050900 ! leukocyte migration
is_a: GO:0060326 ! cell chemotaxis

[Term]
id: GO:0030596
name: alpha-L-rhamnosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides." [EC:3.2.1.40]
subset: gosubset_prok
synonym: "alpha-L-rhamnosidase N" RELATED [EC:3.2.1.40]
synonym: "alpha-L-rhamnosidase T" RELATED [EC:3.2.1.40]
synonym: "alpha-L-rhamnoside rhamnohydrolase activity" EXACT [EC:3.2.1.40]
xref: EC:3.2.1.40
xref: MetaCyc:3.2.1.40-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0030597
name: RNA glycosylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0030598
name: rRNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species." [EC:3.2.2.22, GOC:mah]
subset: gosubset_prok
synonym: "gelonin" RELATED [EC:3.2.2.22]
synonym: "mirabilis antiviral protein" RELATED [EC:3.2.2.22]
synonym: "momorcochin-S" RELATED [EC:3.2.2.22]
synonym: "nigrin b" RELATED [EC:3.2.2.22]
synonym: "ribosomal ribonucleate N-glycosidase activity" EXACT [EC:3.2.2.22]
synonym: "ricin" RELATED [EC:3.2.2.22]
synonym: "RNA N-glycosidase activity" EXACT [EC:3.2.2.22]
synonym: "rRNA N-glycohydrolase activity" EXACT [EC:3.2.2.22]
synonym: "rRNA N-glycosidase activity" EXACT []
synonym: "saporins" RELATED [EC:3.2.2.22]
xref: EC:3.2.2.22
xref: MetaCyc:3.2.2.22-RXN
is_a: GO:0030597 ! RNA glycosylase activity

[Term]
id: GO:0030599
name: pectinesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: pectin + n H2O = n methanol + pectate." [EC:3.1.1.11]
subset: gosubset_prok
synonym: "pectase activity" EXACT [EC:3.1.1.11]
synonym: "pectin demethoxylase activity" EXACT [EC:3.1.1.11]
synonym: "pectin methoxylase activity" EXACT [EC:3.1.1.11]
synonym: "pectin methyl esterase activity" EXACT [EC:3.1.1.11]
synonym: "pectin methylesterase activity" EXACT []
synonym: "pectin pectylhydrolase activity" EXACT [EC:3.1.1.11]
synonym: "pectinoesterase activity" EXACT [EC:3.1.1.11]
xref: EC:3.1.1.11
xref: MetaCyc:PECTINESTERASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0030600
name: feruloyl esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide." [EC:3.1.1.73]
synonym: "4-hydroxy-3-methoxycinnamoyl-sugar hydrolase activity" EXACT [EC:3.1.1.73]
synonym: "cinnAE" RELATED [EC:3.1.1.73]
synonym: "cinnamoyl ester hydrolase activity" EXACT []
synonym: "FAE-I" RELATED [EC:3.1.1.73]
synonym: "FAE-II" RELATED [EC:3.1.1.73]
synonym: "FAE-III" RELATED [EC:3.1.1.73]
synonym: "FAEA" RELATED [EC:3.1.1.73]
synonym: "ferulic acid esterase activity" EXACT [EC:3.1.1.73]
synonym: "hemicellulase accessory" RELATED [EC:3.1.1.73]
synonym: "hydroxycinnamoyl esterase activity" EXACT [EC:3.1.1.73]
xref: EC:3.1.1.73
xref: MetaCyc:3.1.1.73-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0030601
name: aminopeptidase B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys." [EC:3.4.11.6]
comment: This term was made obsolete because it represents a gene product.
synonym: "arginyl aminopeptidase activity" EXACT []
synonym: "arylamidase II" RELATED [EC:3.4.11.6]
synonym: "Cl--activated arginine aminopeptidase activity" EXACT [EC:3.4.11.6]
synonym: "cytosol aminopeptidase IV" RELATED [EC:3.4.11.6]
synonym: "L-arginine aminopeptidase activity" EXACT [EC:3.4.11.6]
xref: EC:3.4.11.6
xref: MetaCyc:3.4.11.6-RXN
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0030602
name: chymosin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein." [EC:3.4.23.4]
comment: This term was made obsolete because it represents a gene product.
synonym: "rennin" RELATED [EC:3.4.23.4]
synonym: "rennin (but this should be avoided since it leads to confusion with renin)" RELATED [EC:3.4.23.4]
xref: EC:3.4.23.4
xref: MetaCyc:3.4.23.4-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0030603
name: oxaloacetase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxaloacetate + H2O = oxalate + acetate." [EC:3.7.1.1]
synonym: "oxalacetic hydrolase activity" EXACT [EC:3.7.1.1]
synonym: "oxaloacetate acetylhydrolase activity" EXACT [EC:3.7.1.1]
xref: EC:3.7.1.1
xref: MetaCyc:OXALOACETASE-RXN
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0030604
name: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+; catalyzes the formation of 2-C-methyl-D-erythritol from 1-deoxy-D-xylulose-5-phosphate as the second step in the non-mevalonate pathway for terpenoid synthesis." [EC:1.1.1.267, GOC:mb]
subset: gosubset_prok
synonym: "1-deoxy-D-xylulose-5-phosphate isomeroreductase activity" EXACT [EC:1.1.1.267]
synonym: "1-deoxyxylulose-5-phosphate reductoisomerase activity" EXACT [EC:1.1.1.267]
synonym: "2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)" EXACT [EC:1.1.1.267]
synonym: "2C-methyl-D-erythritol-4-phosphate (MEP) synthase activity" EXACT [EC:1.1.1.267]
synonym: "DOXP reductoisomerase activity" EXACT []
synonym: "DXP-reductoisomerase activity" EXACT [EC:1.1.1.267]
xref: EC:1.1.1.267
xref: MetaCyc:DXPREDISOM-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0030611
name: arsenate reductase activity
namespace: molecular_function
def: "Catalysis of the interconversion of arsenate and arsenite." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0030612
name: arsenate reductase (thioredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is NADPH -> thioredoxin reductase -> thioredoxin -> arsenate reductase." [GOC:kd]
is_a: GO:0030611 ! arsenate reductase activity

[Term]
id: GO:0030613
name: oxidoreductase activity, acting on phosphorus or arsenic in donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:mah]
comment: Note that enzymes of class EC:1.20.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors" NARROW []
xref: EC:1.20
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0030614
name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:mah]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulphide as acceptor" EXACT []
xref: EC:1.20.4
is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors

[Term]
id: GO:0030616
name: transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
namespace: molecular_function
def: "A TGF-beta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd]
comment: Note that this term can be used in place of the obsolete molecular function term 'common-partner SMAD protein ; GO:0005073' and is useful for annotating proteins of the SMAD family.
synonym: "common-partner SMAD protein" RELATED []
synonym: "TGF-beta receptor, common-partner cytoplasmic mediator activity" EXACT []
synonym: "TGFbeta receptor, common-partner cytoplasmic mediator activity" EXACT []
is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity

[Term]
id: GO:0030617
name: transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
namespace: molecular_function
def: "A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators." [PMID:9759503]
comment: Note that this term can be used in place of the obsolete molecular function term 'inhibitory SMAD protein ; GO:0005074' and is useful for annotating proteins of the SMAD family.
synonym: "inhibitory SMAD protein" RELATED []
synonym: "TGF-beta receptor, inhibitory cytoplasmic mediator activity" EXACT []
synonym: "TGFbeta receptor, inhibitory cytoplasmic mediator activity" EXACT []
is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity

[Term]
id: GO:0030618
name: transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
namespace: molecular_function
def: "A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd]
comment: Note that this term can be used in place of the obsolete molecular function term 'pathway-specific SMAD protein ; GO:0005075' and is useful for annotating proteins of the SMAD family.
synonym: "pathway-specific SMAD protein" NARROW []
synonym: "TGF-beta receptor, pathway-specific cytoplasmic mediator activity" EXACT []
synonym: "TGFbeta receptor, pathway-specific cytoplasmic mediator activity" EXACT []
is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity

[Term]
id: GO:0030619
name: U1 snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA)." [GOC:mah]
comment: Note that this term may be useful for annotating other small nuclear RNAs (snRNAs).
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030620
name: U2 snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030621
name: U4 snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U4 small nuclear RNA (U4 snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030622
name: U4atac snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U4atac small nuclear RNA (U4atac snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030623
name: U5 snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U5 small nuclear RNA (U5 snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030624
name: U6atac snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U6atac small nuclear RNA (U6atac snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030625
name: U11 snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U11 small nuclear RNA (U11 snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030626
name: U12 snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U12 small nuclear RNA (U12 snRNA)." [GOC:jl]
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0030627
name: pre-mRNA 5'-splice site binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the pre-mRNA 5' splice site sequence." [GOC:jl]
synonym: "pre-mRNA 5' splice site binding" EXACT []
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:0030628
name: pre-mRNA 3'-splice site binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the pre-mRNA 3' splice site sequence." [GOC:jl]
synonym: "pre-mRNA 3' splice site binding" EXACT []
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:0030629
name: U6 snRNA 3'-end binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the 3' end of the U6 small nuclear RNA (U6 snRNA)." [GOC:mah]
comment: Note that this term may be useful for annotating small nuclear RNAs (snRNAs).
synonym: "U6 snRNA 3' end binding" EXACT []
is_a: GO:0017070 ! U6 snRNA binding

[Term]
id: GO:0030631
name: pyrrolysine incorporation
namespace: biological_process
def: "The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases." [PMID:11435424, PMID:17204561, RESID:AA0321]
subset: gosubset_prok
synonym: "lysine methylamine methyltransferase cofactor adduct incorporation" EXACT [RESID:AA0321]
synonym: "monomethylamine methyltransferase cofactor lysine adduct incorporation" EXACT [ChEBI:21860]
xref: RESID:AA0321
is_a: GO:0006451 ! translational readthrough

[Term]
id: GO:0030632
name: D-alanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid." [ChEBI:15570, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-alanine anabolism" EXACT []
synonym: "D-alanine biosynthesis" EXACT []
synonym: "D-alanine formation" EXACT []
synonym: "D-alanine synthesis" EXACT []
is_a: GO:0046145 ! D-alanine family amino acid biosynthetic process
is_a: GO:0046436 ! D-alanine metabolic process
is_a: GO:0046437 ! D-amino acid biosynthetic process

[Term]
id: GO:0030633
name: D-alanine family amino acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-alanine and related amino acids." [GOC:mah]
subset: gosubset_prok
synonym: "D-alanine family amino acid breakdown" EXACT []
synonym: "D-alanine family amino acid catabolism" EXACT []
synonym: "D-alanine family amino acid degradation" EXACT []
is_a: GO:0006524 ! alanine catabolic process
is_a: GO:0046144 ! D-alanine family amino acid metabolic process

[Term]
id: GO:0030634
name: carbon fixation by acetyl-CoA pathway
namespace: biological_process
def: "A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2)." [PMID:11607093]
subset: gosubset_prok
synonym: "Ljungdahl-Wood pathway" EXACT []
is_a: GO:0006085 ! acetyl-CoA biosynthetic process
is_a: GO:0015977 ! carbon utilization by fixation of carbon dioxide

[Term]
id: GO:0030635
name: acetate derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving derivatives of acetic acid." [GOC:mah]
subset: gosubset_prok
synonym: "acetate derivative metabolism" EXACT []
is_a: GO:0006083 ! acetate metabolic process

[Term]
id: GO:0030636
name: acetate derivative biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of derivatives of acetic acid." [GOC:mah]
subset: gosubset_prok
synonym: "acetate derivative anabolism" EXACT []
synonym: "acetate derivative biosynthesis" EXACT []
synonym: "acetate derivative formation" EXACT []
synonym: "acetate derivative synthesis" EXACT []
is_a: GO:0019413 ! acetate biosynthetic process
is_a: GO:0030635 ! acetate derivative metabolic process

[Term]
id: GO:0030637
name: acetate derivative catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of derivatives of acetic acid." [GOC:ai]
subset: gosubset_prok
synonym: "acetate derivative breakdown" EXACT []
synonym: "acetate derivative catabolism" EXACT []
synonym: "acetate derivative degradation" EXACT []
is_a: GO:0030635 ! acetate derivative metabolic process
is_a: GO:0045733 ! acetate catabolic process

[Term]
id: GO:0030638
name: polyketide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty-acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "polyketide metabolism" EXACT []
is_a: GO:0030635 ! acetate derivative metabolic process

[Term]
id: GO:0030639
name: polyketide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty-acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "polyketide anabolism" EXACT []
synonym: "polyketide biosynthesis" EXACT []
synonym: "polyketide formation" EXACT []
synonym: "polyketide synthesis" EXACT []
is_a: GO:0030636 ! acetate derivative biosynthetic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0042181 ! ketone biosynthetic process

[Term]
id: GO:0030640
name: polyketide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty-acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "polyketide breakdown" EXACT []
synonym: "polyketide catabolism" EXACT []
synonym: "polyketide degradation" EXACT []
is_a: GO:0030637 ! acetate derivative catabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0042182 ! ketone catabolic process

[Term]
id: GO:0030641
name: regulation of cellular pH
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb]
subset: gosubset_prok
synonym: "cellular hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb]
synonym: "proton homeostasis" EXACT []
is_a: GO:0006885 ! regulation of pH
is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis

[Term]
id: GO:0030642
name: cellular sulfate ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of sulfate ions at the level of a cell." [GOC:mah]
synonym: "sulphate ion homeostasis" BROAD []
is_a: GO:0030319 ! cellular di-, tri-valent inorganic anion homeostasis
is_a: GO:0055063 ! sulfate ion homeostasis

[Term]
id: GO:0030643
name: cellular phosphate ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of phosphate ions at the level of a cell." [GOC:mah]
is_a: GO:0030319 ! cellular di-, tri-valent inorganic anion homeostasis
is_a: GO:0055062 ! phosphate ion homeostasis

[Term]
id: GO:0030644
name: cellular chloride ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of chloride ions at the level of a cell." [GOC:mah]
is_a: GO:0030320 ! cellular monovalent inorganic anion homeostasis
is_a: GO:0055064 ! chloride ion homeostasis

[Term]
id: GO:0030645
name: glucose catabolic process to butyrate
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose, with the production of acetic acid, butyric acid, carbon dioxide (CO2), and dihydrogen; effected by some saccharolytic species of Clostridium, e.g. C. butyricum." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "butyrate fermentation" EXACT []
synonym: "glucose fermentation to butyrate" EXACT []
is_a: GO:0006007 ! glucose catabolic process
is_a: GO:0006113 ! fermentation
is_a: GO:0019605 ! butyrate metabolic process

[Term]
id: GO:0030647
name: aminoglycoside antibiotic metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aminoglycoside antibiotic metabolism" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0016999 ! antibiotic metabolic process

[Term]
id: GO:0030648
name: aminoglycoside antibiotic biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aminoglycoside antibiotic anabolism" EXACT []
synonym: "aminoglycoside antibiotic biosynthesis" EXACT []
synonym: "aminoglycoside antibiotic formation" EXACT []
synonym: "aminoglycoside antibiotic synthesis" EXACT []
is_a: GO:0016138 ! glycoside biosynthetic process
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process

[Term]
id: GO:0030649
name: aminoglycoside antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aminoglycoside antibiotic breakdown" EXACT []
synonym: "aminoglycoside antibiotic catabolism" EXACT []
synonym: "aminoglycoside antibiotic degradation" EXACT []
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process

[Term]
id: GO:0030650
name: peptide antibiotic metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving peptides with antibiotic activity." [GOC:mah]
subset: gosubset_prok
synonym: "peptide antibiotic metabolism" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0016999 ! antibiotic metabolic process

[Term]
id: GO:0030651
name: peptide antibiotic biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptides with antibiotic activity." [GOC:mah]
subset: gosubset_prok
synonym: "peptide antibiotic anabolism" EXACT []
synonym: "peptide antibiotic biosynthesis" EXACT []
synonym: "peptide antibiotic formation" EXACT []
synonym: "peptide antibiotic synthesis" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0030650 ! peptide antibiotic metabolic process
is_a: GO:0043043 ! peptide biosynthetic process

[Term]
id: GO:0030652
name: peptide antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of peptides with antibiotic activity." [GOC:mah]
subset: gosubset_prok
synonym: "peptide antibiotic breakdown" EXACT []
synonym: "peptide antibiotic catabolism" EXACT []
synonym: "peptide antibiotic degradation" EXACT []
is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0030650 ! peptide antibiotic metabolic process
is_a: GO:0043171 ! peptide catabolic process

[Term]
id: GO:0030653
name: beta-lactam antibiotic metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "beta-lactam antibiotic metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0044106 ! cellular amine metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0030654
name: beta-lactam antibiotic biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "beta-lactam antibiotic anabolism" EXACT []
synonym: "beta-lactam antibiotic biosynthesis" EXACT []
synonym: "beta-lactam antibiotic formation" EXACT []
synonym: "beta-lactam antibiotic synthesis" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0030653 ! beta-lactam antibiotic metabolic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0030655
name: beta-lactam antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "beta-lactam antibiotic breakdown" EXACT []
synonym: "beta-lactam antibiotic catabolism" EXACT []
synonym: "beta-lactam antibiotic degradation" EXACT []
is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0030653 ! beta-lactam antibiotic metabolic process
is_a: GO:0043605 ! cellular amide catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0030656
name: regulation of vitamin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of vitamin metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0006766 ! vitamin metabolic process

[Term]
id: GO:0030657
name: regulation of coenzyme and prosthetic group metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
is_obsolete: true
consider: GO:0051196
consider: GO:0051199

[Term]
id: GO:0030658
name: transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a transport vesicle." [GOC:mah]
synonym: "secretory vesicle membrane" BROAD []
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0030133 ! transport vesicle

[Term]
id: GO:0030659
name: cytoplasmic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah]
subset: gosubset_prok
is_a: GO:0012506 ! vesicle membrane
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0030660
name: Golgi-associated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah]
synonym: "Golgi vesicle membrane" RELATED []
is_a: GO:0000139 ! Golgi membrane
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0005798 ! Golgi-associated vesicle

[Term]
id: GO:0030661
name: chitosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a chitosome." [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0045009 ! chitosome

[Term]
id: GO:0030662
name: coated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a coated vesicle." [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0030135 ! coated vesicle

[Term]
id: GO:0030663
name: COPI coated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a COPI-coated vesicle." [GOC:mah]
is_a: GO:0030660 ! Golgi-associated vesicle membrane
is_a: GO:0030662 ! coated vesicle membrane
relationship: part_of GO:0030137 ! COPI-coated vesicle

[Term]
id: GO:0030665
name: clathrin coated vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-coated vesicle." [GOC:mah]
is_a: GO:0030662 ! coated vesicle membrane
relationship: part_of GO:0030136 ! clathrin-coated vesicle

[Term]
id: GO:0030666
name: endocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an endocytic vesicle." [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0030139 ! endocytic vesicle

[Term]
id: GO:0030667
name: secretory granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a secretory granule." [GOC:mah]
synonym: "secretory vesicle membrane" BROAD []
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0030141 ! secretory granule

[Term]
id: GO:0030668
name: merozoite dense granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0020026 ! merozoite dense granule

[Term]
id: GO:0030669
name: clathrin-coated endocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-coated endocytic vesicle." [GOC:mah]
is_a: GO:0030665 ! clathrin coated vesicle membrane
is_a: GO:0030666 ! endocytic vesicle membrane
relationship: part_of GO:0045334 ! clathrin-coated endocytic vesicle

[Term]
id: GO:0030670
name: phagocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a phagocytic vesicle." [GOC:mah]
synonym: "phagosome membrane" EXACT [GOC:mah]
is_a: GO:0030666 ! endocytic vesicle membrane
relationship: part_of GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0030671
name: clathrin-coated phagocytic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin-coated phagocytic vesicle." [GOC:mah]
is_a: GO:0030669 ! clathrin-coated endocytic vesicle membrane
is_a: GO:0030670 ! phagocytic vesicle membrane
relationship: part_of GO:0045336 ! clathrin-coated phagocytic vesicle

[Term]
id: GO:0030672
name: synaptic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a synaptic vesicle." [GOC:mah]
is_a: GO:0030665 ! clathrin coated vesicle membrane
relationship: part_of GO:0008021 ! synaptic vesicle

[Term]
id: GO:0030673
name: axolemma
namespace: cellular_component
def: "The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness." [http://www.medik.sk/clanky/bio_jun.htm, ISBN:0124325653]
synonym: "axonal membrane" EXACT [GOC:vk]
xref: NIF_Subcellular:sao250772229
xref: Wikipedia:Axolemma
is_a: GO:0032589 ! neuron projection membrane
is_a: GO:0033267 ! axon part
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0030674
name: protein binding, bridging
namespace: molecular_function
def: "Interacting selectively and non-covalently with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other." [GOC:mah]
subset: gosubset_prok
synonym: "protein-protein adaptor" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030675
name: Rac GTPase activator activity
namespace: molecular_function
def: "Increases the rate of GTP hydrolysis by a GTPase of the Rac family." [GOC:mah]
synonym: "Rac GAP activity" EXACT [GOC:pg]
is_a: GO:0005100 ! Rho GTPase activator activity

[Term]
id: GO:0030676
name: Rac guanyl-nucleotide exchange factor activity
namespace: molecular_function
def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]
is_a: GO:0005089 ! Rho guanyl-nucleotide exchange factor activity

[Term]
id: GO:0030677
name: ribonuclease P complex
namespace: cellular_component
def: "A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]
comment: Note that chloroplasts possess a complex that is called 'RNase P' because it catalyzes pre-tRNA cleavage, but the chloroplast complex appears not to contain RNA.
subset: goslim_pir
subset: gosubset_prok
synonym: "RNase P complex" EXACT []
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0030678
name: mitochondrial ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species, but the complex often contains a single RNA molecule and a single protein molecule." [GOC:mah, PMID:12045094]
synonym: "mitochondrial RNase P complex" EXACT []
is_a: GO:0030677 ! ribonuclease P complex
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0030679
name: cyanelle ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094]
synonym: "cyanelle RNase P complex" EXACT []
is_a: GO:0030681 ! multimeric ribonuclease P complex
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009842 ! cyanelle

[Term]
id: GO:0030680
name: dimeric ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species." [GOC:mah, PMID:12045094]
subset: gosubset_prok
synonym: "dimeric RNase P complex" EXACT []
is_a: GO:0030677 ! ribonuclease P complex

[Term]
id: GO:0030681
name: multimeric ribonuclease P complex
namespace: cellular_component
def: "A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species." [GOC:mah, PMID:11142368, PMID:12045094]
synonym: "multimeric RNase P complex" EXACT []
is_a: GO:0030677 ! ribonuclease P complex

[Term]
id: GO:0030682
name: evasion or tolerance of host defense response
namespace: biological_process
def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "evasion of host defence response" EXACT []
is_a: GO:0044415 ! evasion or tolerance of host defenses
is_a: GO:0051807 ! evasion or tolerance of defense response of other organism during symbiotic interaction

[Term]
id: GO:0030683
name: evasion by virus of host immune response
namespace: biological_process
def: "Any process, either active or passive, by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah]
xref: Reactome:168305 "Inhibition of Interferon Synthesis"
xref: Reactome:168888 "Inhibition of IFN-beta"
xref: Reactome:168891 "Binding of NS1 to dsRNA"
xref: Reactome:168896 "Binding of NS1 to PKR"
xref: Reactome:169131 "Inhibition of PKR"
is_a: GO:0019049 ! evasion of host defenses by virus
is_a: GO:0020012 ! evasion or tolerance of host immune response

[Term]
id: GO:0030684
name: preribosome
namespace: cellular_component
def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516]
subset: goslim_pir
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0030685
name: nucleolar preribosome
namespace: cellular_component
def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis." [PMID:10567516]
is_a: GO:0030684 ! preribosome
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0030686
name: 90S preribosome
namespace: cellular_component
def: "A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [PMID:12150911, PMID:12957375, PMID:15120992]
is_a: GO:0030684 ! preribosome

[Term]
id: GO:0030687
name: preribosome, large subunit precursor
namespace: cellular_component
def: "A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516]
comment: Note that this complex is 66S in Saccharomyces.
synonym: "66S preribosome" NARROW []
is_a: GO:0030684 ! preribosome

[Term]
id: GO:0030688
name: preribosome, small subunit precursor
namespace: cellular_component
def: "A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516]
comment: Note that this complex is 43S in Saccharomyces.
synonym: "43S preribosome" NARROW []
is_a: GO:0030684 ! preribosome

[Term]
id: GO:0030689
name: Noc complex
namespace: cellular_component
def: "Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis." [PMID:12446671]
comment: Note that the definition uses Saccharomyces gene product names because this complex has only been described in Saccharomyces cerevisiae and no other names have yet arisen; the term nevertheless can be used for analogous complexes in other eukaryotes, and the definition can be changed if better wording is found.
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0030690
name: Noc1p-Noc2p complex
namespace: cellular_component
def: "A heterodimer associated with 90S and 66S preribosomes in the nucleolus; involved in ribosomal large subunit biogenesis." [PMID:12446671]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
is_a: GO:0030689 ! Noc complex
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044452 ! nucleolar part
relationship: part_of GO:0030686 ! 90S preribosome
relationship: part_of GO:0030687 ! preribosome, large subunit precursor

[Term]
id: GO:0030691
name: Noc2p-Noc3p complex
namespace: cellular_component
def: "A heterodimer associated with 66S preribosomes; also found throughout the nucleoplasm; involved in ribosomal large subunit biogenesis." [PMID:12446671]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
is_a: GO:0030689 ! Noc complex
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0044452 ! nucleolar part
relationship: part_of GO:0030687 ! preribosome, large subunit precursor

[Term]
id: GO:0030692
name: Noc4p-Nop14p complex
namespace: cellular_component
def: "A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis." [PMID:12446671]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
synonym: "Nop7 complex" EXACT [GOC:jh, GOC:mah]
synonym: "Nop7 subcomplex" EXACT [GOC:jh, GOC:mah, PMID:18448671]
is_a: GO:0030689 ! Noc complex
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044452 ! nucleolar part
relationship: part_of GO:0030686 ! 90S preribosome
relationship: part_of GO:0030688 ! preribosome, small subunit precursor

[Term]
id: GO:0030693
name: caspase activity
namespace: molecular_function
alt_id: GO:0004199
def: "OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue." [PMID:10872455]
comment: This term was made obsolete because it represents a gene product.
synonym: "caspase-1 activity" NARROW []
synonym: "caspase-10 activity" NARROW []
synonym: "caspase-2 activity" NARROW []
synonym: "caspase-3 activity" NARROW []
synonym: "caspase-4 activity" NARROW []
synonym: "caspase-5 activity" NARROW []
synonym: "caspase-6 activity" NARROW []
synonym: "caspase-7 activity" NARROW []
synonym: "caspase-8 activity" NARROW []
synonym: "caspase-9 activity" NARROW []
synonym: "effector caspase activity" NARROW []
synonym: "signaling (initiator) caspase activity" NARROW []
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0030694
name: bacterial-type flagellum basal body, rod
namespace: cellular_component
def: "The central portion of the flagellar basal body, which spans the periplasm and threads through the rings. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192]
subset: gosubset_prok
synonym: "flagellar basal body, rod" EXACT []
synonym: "flagellin-based flagellum basal body, rod" EXACT []
is_a: GO:0044461 ! bacterial-type flagellum part
relationship: part_of GO:0009425 ! bacterial-type flagellum basal body

[Term]
id: GO:0030695
name: GTPase regulator activity
namespace: molecular_function
def: "Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah]
subset: gosubset_prok
is_a: GO:0060589 ! nucleoside-triphosphatase regulator activity

[Term]
id: GO:0030696
name: tRNA (m5U54) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337 "Modification and Editing of RNA"]
comment: Note that the term name mentions a specific position within a tRNA because no other names have yet arisen for this activity, and because the position is conserved in nearly all tRNAs. The term nevertheless can be used for activities that methylase an analogous residue at a position other than 54, if such is found, and synonyms that mention positions applicable to other tRNAs or species may also be added.
synonym: "RUMT" EXACT []
is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity

[Term]
id: GO:0030697
name: S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337 "Modification and Editing of RNA"]
synonym: "RUMT" BROAD []
synonym: "S-adenosyl methionine-dependent tRNA (m5U54) methyltransferase activity" EXACT []
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
is_a: GO:0030696 ! tRNA (m5U54) methyltransferase activity

[Term]
id: GO:0030698
name: 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337 "Modification and Editing of RNA"]
synonym: "RUMT" BROAD []
is_a: GO:0030696 ! tRNA (m5U54) methyltransferase activity
is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity

[Term]
id: GO:0030699
name: glycine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl phosphate + ammonia + thioredoxin disulfide = glycine + phosphate + thioredoxin." [EC:1.21.4.2]
subset: gosubset_prok
synonym: "acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming)" EXACT [EC:1.21.4.2]
xref: EC:1.21.4.2
xref: MetaCyc:RXN-7566
is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor

[Term]
id: GO:0030700
name: glycine reductase complex
namespace: cellular_component
def: "Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C." [GOC:mah, PMID:2018775]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glycine reductase activity ; GO:0030699'.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0030701
name: NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]." [EC:2.4.2.37]
subset: gosubset_prok
synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.37]
synonym: "NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase activity" EXACT [EC:2.4.2.37]
synonym: "NAD--azoferredoxin (ADP-ribose)transferase activity" EXACT [EC:2.4.2.37]
synonym: "NAD-azoferredoxin (ADPribose)transferase activity" EXACT [EC:2.4.2.37]
synonym: "NAD-dinitrogen-reductase ADP-D-ribosyltransferase activity" EXACT []
xref: EC:2.4.2.37
xref: MetaCyc:2.4.2.37-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0030702
name: chromatin silencing at centromere
namespace: biological_process
def: "Repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:mah]
synonym: "heterochromatic silencing at centromere" EXACT []
is_a: GO:0006342 ! chromatin silencing

[Term]
id: GO:0030703
name: eggshell formation
namespace: biological_process
def: "Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration." [GOC:mtg_sensu, ISBN:0879694238, PMID:10822261]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0030704
name: vitelline membrane formation
namespace: biological_process
def: "Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg." [ISBN:0879694238]
is_a: GO:0030198 ! extracellular matrix organization
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0030705
name: cytoskeleton-dependent intracellular transport
namespace: biological_process
def: "The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell." [GOC:mah]
subset: gosubset_prok
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0030706
name: germarium-derived oocyte differentiation
namespace: biological_process
def: "The process whereby one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "oocyte cell differentiation" RELATED []
is_a: GO:0009994 ! oocyte differentiation
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation

[Term]
id: GO:0030707
name: ovarian follicle cell development
namespace: biological_process
def: "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0030708
name: germarium-derived female germ-line cyst encapsulation
namespace: biological_process
def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11591336]
is_a: GO:0048139 ! female germ-line cyst encapsulation
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation
relationship: part_of GO:0030707 ! ovarian follicle cell development

[Term]
id: GO:0030709
name: border follicle cell delamination
namespace: biological_process
def: "The splitting off of border cells from the anterior epithelium, prior to border cell migration." [PMID:10822261]
synonym: "border cell delamination" BROAD []
is_a: GO:0060232 ! delamination
relationship: part_of GO:0030707 ! ovarian follicle cell development

[Term]
id: GO:0030710
name: regulation of border follicle cell delamination
namespace: biological_process
def: "Any process that regulates the frequency, rate or extent of border cell delamination." [PMID:10822261]
synonym: "regulation of border cell delamination" BROAD []
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0030709 ! border follicle cell delamination

[Term]
id: GO:0030711
name: positive regulation of border follicle cell delamination
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of border cell delamination." [PMID:10822261]
synonym: "activation of border follicle cell delamination" NARROW []
synonym: "positive regulation of border cell delamination" BROAD []
synonym: "stimulation of border follicle cell delamination" NARROW []
synonym: "up regulation of border follicle cell delamination" EXACT []
synonym: "up-regulation of border follicle cell delamination" EXACT []
synonym: "upregulation of border follicle cell delamination" EXACT []
is_a: GO:0030710 ! regulation of border follicle cell delamination
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0030709 ! border follicle cell delamination

[Term]
id: GO:0030712
name: negative regulation of border follicle cell delamination
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of border cell delamination." [PMID:10822261]
synonym: "down regulation of border follicle cell delamination" EXACT []
synonym: "down-regulation of border follicle cell delamination" EXACT []
synonym: "downregulation of border follicle cell delamination" EXACT []
synonym: "inhibition of border follicle cell delamination" NARROW []
synonym: "negative regulation of border cell delamination" BROAD []
is_a: GO:0030710 ! regulation of border follicle cell delamination
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0030709 ! border follicle cell delamination

[Term]
id: GO:0030713
name: ovarian follicle cell stalk formation
namespace: biological_process
def: "Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0030707 ! ovarian follicle cell development

[Term]
id: GO:0030714
name: anterior/posterior axis specification, follicular epithelium
namespace: biological_process
def: "Polarization of the follicle cells of an insect ovary along the anterior/posterior axis." [GOC:bf]
synonym: "anterior/posterior axis determination, follicular epithelium" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009798 ! axis specification
is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium
relationship: part_of GO:0030707 ! ovarian follicle cell development

[Term]
id: GO:0030715
name: oocyte growth in germarium-derived egg chamber
namespace: biological_process
def: "The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]
is_a: GO:0001555 ! oocyte growth
relationship: part_of GO:0007295 ! growth of a germarium-derived egg chamber

[Term]
id: GO:0030716
name: oocyte fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
synonym: "oocyte cell fate determination" EXACT []
is_a: GO:0001709 ! cell fate determination

[Term]
id: GO:0030717
name: karyosome formation
namespace: biological_process
def: "The chromosome organization process by which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]
is_a: GO:0051276 ! chromosome organization
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0030718
name: germ-line stem cell maintenance
namespace: biological_process
def: "Any process involved in preventing uncommitted germ-line stem cells from differentiating as another cell type." [ISBN:0879694238]
is_a: GO:0019827 ! stem cell maintenance

[Term]
id: GO:0030719
name: P granule organization
namespace: biological_process
alt_id: GO:0048114
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367]
synonym: "P granule organization and biogenesis" RELATED []
synonym: "polar granule organisation" EXACT [GOC:curators]
synonym: "polar granule organization and biogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006996 ! organelle organization
relationship: part_of GO:0007315 ! pole plasm assembly

[Term]
id: GO:0030720
name: oocyte localization during germarium-derived egg chamber formation
namespace: biological_process
def: "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356]
synonym: "establishment and maintenance of oocyte localization in egg chamber" EXACT []
synonym: "establishment and maintenance of oocyte position during oogenesis" EXACT []
synonym: "oocyte localization during oogenesis" RELATED []
synonym: "oocyte positioning during oogenesis" NARROW []
synonym: "oogenesis, establishment and maintenance of oocyte localization" EXACT []
synonym: "oogenesis, oocyte localization" EXACT []
is_a: GO:0051674 ! localization of cell
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation

[Term]
id: GO:0030721
name: spectrosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome." [PMID:11131529]
synonym: "spectrosome organisation" EXACT [GOC:curators]
synonym: "spectrosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0030722
name: establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification
namespace: biological_process
alt_id: GO:0048126
def: "The directed movement of the nucleus to a specific location within the cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte. In the insect oocyte, for example, the nucleus is repositioned to a dorso-anterior position." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb]
synonym: "establishment of localization of oocyte nucleus during oocyte axis determination" BROAD []
synonym: "establishment of oocyte nucleus localization during oocyte axis determination" BROAD [GOC:dph, GOC:tb]
synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal-ventral axis specification" EXACT [GOC:mah]
synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb]
synonym: "establishment of oocyte nucleus localization involved in oocyte dorsoventral axis specification" EXACT [GOC:mah]
synonym: "nucleus positioning in oocyte during oocyte axis determination" BROAD []
synonym: "oocyte axis determination, establishment of localization of nucleus" BROAD []
synonym: "oocyte axis determination, establishment of oocyte nucleus localization" BROAD []
synonym: "oocyte axis determination, establishment of position of nucleus" BROAD []
synonym: "oocyte axis determination, positioning of nucleus" BROAD []
synonym: "oocyte nucleus positioning during oocyte axis determination" BROAD []
is_a: GO:0040023 ! establishment of nucleus localization
relationship: part_of GO:0051663 ! oocyte nucleus localization involved in oocyte dorsal/ventral axis specification

[Term]
id: GO:0030723
name: ovarian fusome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]
synonym: "ovarian fusome organisation" EXACT [GOC:curators]
synonym: "ovarian fusome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045478 ! fusome organization
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation

[Term]
id: GO:0030724
name: testicular fusome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of testicular cells, an organelle derived from the spectrosome." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]
synonym: "testicular fusome organisation" EXACT [GOC:curators]
synonym: "testicular fusome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045478 ! fusome organization
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0030725
name: germline ring canal formation
namespace: biological_process
def: "Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts." [ISBN:0879694238]
synonym: "ring canal formation" BROAD []
is_a: GO:0043063 ! intercellular bridge organization

[Term]
id: GO:0030726
name: male germline ring canal formation
namespace: biological_process
def: "Formation of the intercellular bridges that connect the germ-line cells of a male cyst." [ISBN:0879694238]
synonym: "spermatocyte ring canal formation" NARROW []
synonym: "testicular ring canal formation" NARROW []
is_a: GO:0030725 ! germline ring canal formation
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0030727
name: germarium-derived female germ-line cyst formation
namespace: biological_process
def: "Formation of a cluster of germ-line cells, in the germarium, derived from a single founder cell (cystoblast). An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240]
is_a: GO:0048135 ! female germ-line cyst formation
relationship: part_of GO:0007293 ! germarium-derived egg chamber formation

[Term]
id: GO:0030728
name: ovulation
namespace: biological_process
def: "The release of a mature ovum/oocyte from an ovary." [GOC:bf, ISBN:0878932437]
xref: Wikipedia:Ovulation
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0007292 ! female gamete generation

[Term]
id: GO:0030729
name: acetoacetate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA." [EC:6.2.1.16]
subset: gosubset_prok
synonym: "acetoacetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.16]
synonym: "acetoacetyl-CoA synthetase activity" EXACT []
xref: EC:6.2.1.16
xref: MetaCyc:ACETOACETATE--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0030730
name: sequestering of triglyceride
namespace: biological_process
def: "The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "retention of triacylglycerol" EXACT []
synonym: "retention of triglyceride" EXACT []
synonym: "sequestering of triacylglycerol" EXACT []
synonym: "sequestration of triacylglycerol" EXACT []
synonym: "sequestration of triglyceride" EXACT []
synonym: "storage of triacylglycerol" EXACT []
synonym: "storage of triglyceride" EXACT []
synonym: "triacylglycerol retention" EXACT []
synonym: "triacylglycerol sequestering" EXACT []
synonym: "triacylglycerol sequestration" EXACT []
synonym: "triacylglycerol storage" EXACT []
synonym: "triglyceride retention" EXACT []
synonym: "triglyceride sequestering" EXACT []
synonym: "triglyceride sequestration" EXACT []
synonym: "triglyceride storage" EXACT []
is_a: GO:0019915 ! lipid storage
is_a: GO:0051235 ! maintenance of location

[Term]
id: GO:0030731
name: guanidinoacetate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine." [EC:2.1.1.2]
synonym: "GA methylpherase activity" EXACT [EC:2.1.1.2]
synonym: "guanidinoacetate methyltransferase activity" EXACT [EC:2.1.1.2]
synonym: "guanidinoacetate transmethylase activity" EXACT [EC:2.1.1.2]
synonym: "guanidoacetate methyltransferase activity" EXACT [EC:2.1.1.2]
synonym: "methionine-guanidinoacetic transmethylase activity" EXACT [EC:2.1.1.2]
synonym: "S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase activity" EXACT [EC:2.1.1.2]
xref: EC:2.1.1.2
xref: MetaCyc:GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030732
name: methionine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine." [EC:2.1.1.12]
synonym: "methionine methyltransferase activity" EXACT [EC:2.1.1.12]
synonym: "S-adenosyl methionine:methionine methyl transferase activity" EXACT [EC:2.1.1.12]
synonym: "S-adenosyl-L-methionine:L-methionine S-methyltransferase activity" EXACT [EC:2.1.1.12]
synonym: "S-adenosylmethionine transmethylase activity" EXACT [EC:2.1.1.12]
synonym: "S-adenosylmethionine-methionine methyltransferase activity" EXACT [EC:2.1.1.12]
xref: EC:2.1.1.12
xref: MetaCyc:METHIONINE-S-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030733
name: fatty-acid O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester." [EC:2.1.1.15]
synonym: "fatty acid methyltransferase activity" EXACT [EC:2.1.1.15]
synonym: "fatty acid O-methyltransferase activity" EXACT [EC:2.1.1.15]
synonym: "S-adenosyl-L-methionine:fatty-acid O-methyltransferase activity" EXACT [EC:2.1.1.15]
xref: EC:2.1.1.15
xref: MetaCyc:FATTY-ACID-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030734
name: polysaccharide O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units." [EC:2.1.1.18]
synonym: "acylpolysacharide 6-methyltransferase activity" EXACT [EC:2.1.1.18]
synonym: "polysaccharide methyltransferase activity" EXACT [EC:2.1.1.18]
synonym: "S-adenosyl-L-methionine:1,4-alpha-D-glucan 6-O-methyltransferase activity" EXACT [EC:2.1.1.18]
xref: EC:2.1.1.18
xref: MetaCyc:POLYSACCHARIDE-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030735
name: carnosine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine." [EC:2.1.1.22]
synonym: "S-adenosyl-L-methionine:carnosine N-methyltransferase activity" EXACT [EC:2.1.1.22]
xref: EC:2.1.1.22
xref: MetaCyc:CARNOSINE-N-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030736
name: phenol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole." [EC:2.1.1.25]
synonym: "PMT" RELATED [EC:2.1.1.25]
synonym: "S-adenosyl-L-methionine:phenol O-methyltransferase activity" EXACT [EC:2.1.1.25]
xref: EC:2.1.1.25
xref: MetaCyc:PHENOL-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030737
name: iodophenol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-iodophenol = S-adenosyl-L-homocysteine + 2-iodophenol methyl ether." [EC:2.1.1.26]
synonym: "S-adenosyl-L-methionine:2-iodophenol O-methyltransferase activity" EXACT [EC:2.1.1.26]
xref: EC:2.1.1.26
xref: MetaCyc:IODOPHENOL-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030738
name: tyramine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = S-adenosyl-L-homocysteine + N-methyltyramine." [EC:2.1.1.27]
synonym: "DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid)" EXACT [EC:2.1.1.27]
synonym: "S-adenosyl-L-methionine:tyramine N-methyltransferase activity" EXACT [EC:2.1.1.27]
synonym: "S-adenosyl-methionine:tyramine N-methyltransferase activity" EXACT [EC:2.1.1.27]
synonym: "tyramine methylpherase activity" EXACT [EC:2.1.1.27]
xref: EC:2.1.1.27
xref: MetaCyc:TYRAMINE-N-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030739
name: O-demethylpuromycin O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin." [EC:2.1.1.38]
subset: gosubset_prok
synonym: "O-demethylpuromycin methyltransferase activity" EXACT [EC:2.1.1.38]
synonym: "S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase activity" EXACT [EC:2.1.1.38]
xref: EC:2.1.1.38
xref: MetaCyc:2.1.1.38-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030740
name: inositol 3-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 1D-3-O-methyl-myo-inositol." [EC:2.1.1.39]
synonym: "inositol L-1-methyltransferase activity" EXACT [EC:2.1.1.39]
synonym: "myo-inositol 1-methyltransferase activity" RELATED [EC:2.1.1.39]
synonym: "myo-inositol 1-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" EXACT [EC:2.1.1.39]
synonym: "myo-inositol 1-O-methyltransferase activity" RELATED [EC:2.1.1.39]
synonym: "S-adenosyl-L-methionine:1D-myo-inositol 3-O-methyltransferase activity" EXACT [EC:2.1.1.39]
synonym: "S-adenosyl-L-methionine:myo-inositol 1-O-methyltransferase activity" EXACT [EC:2.1.1.39]
synonym: "S-adenosylmethionine:myo-inositol 1-methyltransferase activity" EXACT [EC:2.1.1.39]
xref: EC:2.1.1.39
xref: MetaCyc:MYO-INOSITOL-1-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030741
name: inositol 1-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 1D-1-O-methyl-myo-inositol." [EC:2.1.1.40]
synonym: "inositol 3-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" EXACT [EC:2.1.1.40]
synonym: "inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40]
synonym: "inositol D-1-methyltransferase activity" EXACT [EC:2.1.1.40]
synonym: "myo-inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40]
synonym: "S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase activity" EXACT [EC:2.1.1.40]
synonym: "S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase activity" EXACT [EC:2.1.1.40]
synonym: "S-adenosylmethionine:myo-inositol 3-methyltransferase activity" RELATED [EC:2.1.1.40]
xref: EC:2.1.1.40
xref: MetaCyc:MYO-INOSITOL-3-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030742
name: GTP-dependent protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP." [GOC:go_curators]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030743
name: rRNA (adenosine-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine." [EC:2.1.1.66]
subset: gosubset_prok
synonym: "ribosomal ribonucleate adenosine 2'-methyltransferase activity" EXACT [EC:2.1.1.66]
synonym: "RNA-pentose methylase activity" RELATED [EC:2.1.1.66]
synonym: "rRNA adenosine 2'-methylase activity" EXACT [EC:2.1.1.66]
synonym: "S-adenosyl-L-methionine:rRNA (adenosine-2'-O)-methyltransferase activity" EXACT [EC:2.1.1.66]
synonym: "thiostrepton-resistance methylase activity" NARROW [EC:2.1.1.66]
xref: EC:2.1.1.66
xref: MetaCyc:2.1.1.66-RXN
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity

[Term]
id: GO:0030744
name: luteolin O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,3',4'-tetrahydroxyflavone = S-adenosyl-L-homocysteine + 5,7,4'-trihydroxy-3'-methoxyflavone." [EC:2.1.1.42]
synonym: "luteolin 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42]
synonym: "luteolin methyltransferase activity" EXACT [EC:2.1.1.42]
synonym: "o-dihydric phenol meta-O-methyltransferase activity" EXACT [EC:2.1.1.42]
synonym: "o-dihydric phenol methyltransferase activity" EXACT [EC:2.1.1.42]
synonym: "o-diphenol m-O-methyltransferase activity" EXACT [EC:2.1.1.42]
synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxyflavone 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42]
synonym: "S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42]
xref: EC:2.1.1.42
xref: MetaCyc:LUTEOLIN-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030745
name: dimethylhistidine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + NN1,NN1-dimethyl-L-histidine = S-adenosyl-L-homocysteine + NN1,NN1,NN1-trimethyl-L-histidine." [EC:2.1.1.44]
synonym: "dimethylhistidine methyltransferase activity" EXACT [EC:2.1.1.44]
synonym: "histidine-alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44]
synonym: "S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44]
synonym: "S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine nalpha-methyltransferase activity" EXACT [EC:2.1.1.44]
xref: EC:2.1.1.44
xref: MetaCyc:2.1.1.44-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030746
name: isoflavone 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone." [EC:2.1.1.46]
synonym: "4'-hydroxyisoflavone methyltransferase activity" EXACT [EC:2.1.1.46]
synonym: "isoflavone methyltransferase activity" EXACT [EC:2.1.1.46]
synonym: "isoflavone O-methyltransferase activity" EXACT [EC:2.1.1.46]
synonym: "S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.46]
xref: EC:2.1.1.46
xref: MetaCyc:ISOFLAVONE-4-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030747
name: indolepyruvate C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (S)-3-(indol-3-yl)-2-oxobutanoate." [EC:2.1.1.47]
synonym: "indolepyruvate 3-methyltransferase activity" EXACT [EC:2.1.1.47]
synonym: "indolepyruvate methyltransferase activity" EXACT [EC:2.1.1.47]
synonym: "indolepyruvic acid methyltransferase activity" EXACT [EC:2.1.1.47]
synonym: "S-adenosyl-L-methionine:(indol-3-yl)pyruvate C-methyltransferase activity" EXACT [EC:2.1.1.47]
synonym: "S-adenosyl-L-methionine:indolepyruvate C-methyltransferase activity" EXACT [EC:2.1.1.47]
xref: EC:2.1.1.47
xref: MetaCyc:INDOLEPYRUVATE-C-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030748
name: amine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine." [EC:2.1.1.49]
synonym: "arylamine N-methyltransferase activity" NARROW [EC:2.1.1.49]
synonym: "nicotine N-methyltransferase activity" NARROW [EC:2.1.1.49]
synonym: "S-adenosyl-L-methionine:amine N-methyltransferase activity" EXACT [EC:2.1.1.49]
synonym: "tryptamine methyltransferase" NARROW [EC:2.1.1.49]
synonym: "tryptamine N-methyltransferase activity" NARROW [EC:2.1.1.49]
xref: EC:2.1.1.49
xref: MetaCyc:AMINE-N-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030749
name: loganate O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin." [EC:2.1.1.50]
synonym: "loganate methyltransferase activity" EXACT [EC:2.1.1.50]
synonym: "S-adenosyl-L-methionine:loganate 11-O-methyltransferase activity" EXACT [EC:2.1.1.50]
synonym: "S-adenosyl-L-methionine:loganic acid methyltransferase activity" EXACT [EC:2.1.1.50]
xref: EC:2.1.1.50
xref: MetaCyc:LOGANATE-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030750
name: putrescine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = S-adenosyl-L-homocysteine + N-methylputrescine." [EC:2.1.1.53]
synonym: "putrescine methyltransferase activity" EXACT [EC:2.1.1.53]
synonym: "S-adenosyl-L-methionine:putrescine N-methyltransferase activity" EXACT [EC:2.1.1.53]
xref: EC:2.1.1.53
xref: MetaCyc:PUTRESCINE-N-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030751
name: licodione 2'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + licodione = S-adenosyl-L-homocysteine + 2'-O-methyllicodione." [EC:2.1.1.65]
synonym: "S-adenosyl-L-methionine:licodione 2'-O-methyltransferase activity" EXACT [EC:2.1.1.65]
xref: EC:2.1.1.65
xref: MetaCyc:LICODIONE-2-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030752
name: 5-hydroxyfuranocoumarin 5-O-methyltransferase activity
namespace: molecular_function
alt_id: GO:0030764
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin." [EC:2.1.1.69]
synonym: "bergaptol 5-O-methyltransferase activity" EXACT [EC:2.1.1.69]
synonym: "bergaptol methyltransferase activity" EXACT [EC:2.1.1.69]
synonym: "bergaptol O-methyltransferase activity" EXACT [EC:2.1.1.69]
synonym: "BMT activity" EXACT [EC:2.1.1.69]
synonym: "furanocoumarin 5-methyltransferase activity" EXACT [EC:2.1.1.69]
synonym: "furanocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69]
synonym: "S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69]
synonym: "S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69]
synonym: "S-adenosyl-L-methionine:bergaptol O-methyltransferase activity" EXACT [EC:2.1.1.69]
synonym: "S-adenosyl-L-methionine:bergaptolO-methyltransferase activity" EXACT [EC:2.1.1.69]
xref: EC:2.1.1.69
xref: MetaCyc:2.1.1.69-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030753
name: 8-hydroxyfuranocoumarin 8-O-methyltransferase activity
namespace: molecular_function
alt_id: GO:0030765
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 8-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 8-methoxyfuranocoumarin." [EC:2.1.1.70]
synonym: "furanocoumarin 8-methyltransferase activity" EXACT [EC:2.1.1.70]
synonym: "furanocoumarin 8-O-methyl-transferase activity" EXACT [EC:2.1.1.70]
synonym: "S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.70]
synonym: "S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.70]
synonym: "S-adenosyl-L-methionine:xanthotoxol O-methyltransferase activity" EXACT [EC:2.1.1.70]
synonym: "xanthotoxol 8-O-methyltransferase activity" EXACT [EC:2.1.1.70]
synonym: "xanthotoxol methyltransferase activity" EXACT [EC:2.1.1.70]
synonym: "xanthotoxol O-methyltransferase activity" EXACT []
synonym: "XMT activity" RELATED [EC:2.1.1.70]
xref: EC:2.1.1.70
xref: MetaCyc:2.1.1.70-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030754
name: apigenin 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone." [EC:2.1.1.75]
synonym: "flavonoid methyltransferase activity" EXACT [EC:2.1.1.75]
synonym: "flavonoid O-methyltransferase activity" BROAD [EC:2.1.1.75]
synonym: "S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.75]
xref: EC:2.1.1.75
xref: MetaCyc:APIGENIN-4-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030755
name: quercetin 3-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone." [EC:2.1.1.76]
synonym: "flavonoid 3-methyltransferase activity" EXACT [EC:2.1.1.76]
synonym: "flavonol 3-O-methyltransferase activity" RELATED [EC:2.1.1.76]
synonym: "S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase activity" EXACT [EC:2.1.1.76]
xref: EC:2.1.1.76
xref: MetaCyc:QUERCETIN-3-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030756
name: isoorientin 3'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoorientin = S-adenosyl-L-homocysteine + isoscoparin." [EC:2.1.1.78]
synonym: "isoorientin 3'-methyltransferase activity" EXACT [EC:2.1.1.78]
synonym: "S-adenosyl-L-methionine:isoorientin 3'-O-methyltransferase activity" EXACT [EC:2.1.1.78]
xref: EC:2.1.1.78
xref: MetaCyc:ISOORIENTIN-3-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030757
name: 3-methylquercitin 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3',4',5,7-tetrahydroxy-3-methoxyflavone = S-adenosyl-L-homocysteine + 3',4',5-trihydroxy-3,7-dimethoxy-flavone." [EC:2.1.1.82]
synonym: "3-methylquercetin 7-O-methyltransferase activity" EXACT [EC:2.1.1.82]
synonym: "7-OMT activity" RELATED [EC:2.1.1.82]
synonym: "flavonol 7-methyltransferase activity" RELATED [EC:2.1.1.82]
synonym: "flavonol 7-O-methyltransferase activity" RELATED [EC:2.1.1.82]
synonym: "S-adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.82]
synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.82]
xref: EC:2.1.1.82
xref: MetaCyc:2.1.1.82-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030758
name: 3,7-dimethylquercitin 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3',4',5-trihydroxy-3,7-dimethoxyflavone = S-adenosyl-L-homocysteine + 3',5-dihydroxy-3,4',7-trimethoxy-flavone." [EC:2.1.1.83]
synonym: "3,7-dimethylquercetin 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83]
synonym: "4'-OMT activity" RELATED [EC:2.1.1.83]
synonym: "flavonol 4'-methyltransferase activity" RELATED [EC:2.1.1.83]
synonym: "flavonol 4'-O-methyltransferase activity" RELATED [EC:2.1.1.83]
synonym: "S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83]
synonym: "S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83]
xref: EC:2.1.1.83
xref: MetaCyc:2.1.1.83-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030759
name: methylquercetagetin 6-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3',4',5,6-tetrahydroxy-3,7-dimethoxy-flavone = S-adenosyl-L-homocysteine + 3',4',5-trihydroxy-3,6,7-trimethoxyflavone." [EC:2.1.1.84]
synonym: "6-OMT" RELATED [EC:2.1.1.84]
synonym: "flavonol 6-methyltransferase activity" EXACT [EC:2.1.1.84]
synonym: "flavonol 6-O-methyltransferase activity" RELATED [EC:2.1.1.84]
synonym: "S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase activity" EXACT [EC:2.1.1.84]
xref: EC:2.1.1.84
xref: MetaCyc:2.1.1.84-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030760
name: pyridine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + pyridine = S-adenosyl-L-homocysteine + N-methylpyridinium." [EC:2.1.1.87]
synonym: "pyridine methyltransferase activity" EXACT [EC:2.1.1.87]
synonym: "S-adenosyl-L-methionine:pyridine N-methyltransferase activity" EXACT [EC:2.1.1.87]
xref: EC:2.1.1.87
xref: MetaCyc:PYRIDINE-N-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030761
name: 8-hydroxyquercitin 8-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,3',4',5,7,8-hexahydroxyflavone = S-adenosyl-L-homocysteine + 3,3',4',5,7-pentahydroxy-8-methoxy-flavone." [EC:2.1.1.88]
synonym: "8-hydroxyquercetin 8-O-methyltransferase activity" EXACT [EC:2.1.1.88]
synonym: "flavonol 8-methyltransferase activity" EXACT [EC:2.1.1.88]
synonym: "flavonol 8-O-methyltransferase activity" RELATED [EC:2.1.1.88]
synonym: "S-adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone 8-O-methyltransferase activity" EXACT [EC:2.1.1.88]
xref: EC:2.1.1.88
xref: MetaCyc:2.1.1.88-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030762
name: tetrahydrocolumbamine 2-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine = S-adenosyl-L-homocysteine + tetrahydropalmatine." [EC:2.1.1.89]
synonym: "S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase activity" EXACT [EC:2.1.1.89]
synonym: "tetrahydrocolumbamine methyltransferase activity" EXACT [EC:2.1.1.89]
xref: EC:2.1.1.89
xref: MetaCyc:2.1.1.89-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030763
name: isobutyraldoxime O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-methylpropanal oxime = S-adenosyl-L-homocysteine + 2-methylpropanal O-methyloxime." [EC:2.1.1.91]
synonym: "aldoxime methyltransferase activity" EXACT [EC:2.1.1.91]
synonym: "aldoxime O-methyltransferase activity" EXACT [EC:2.1.1.91]
synonym: "S-adenosyl-L-methionine:2-methylpropanal-oxime O-methyltransferase activity" EXACT [EC:2.1.1.91]
synonym: "S-adenosylmethionine:aldoxime O-methyltransferase activity" EXACT [EC:2.1.1.91]
xref: EC:2.1.1.91
xref: MetaCyc:ISOBUTYRALDOXIME-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030766
name: 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline." [EC:2.1.1.94]
synonym: "11-demethyl-17-deacetylvindoline 11-methyltransferase activity" EXACT [EC:2.1.1.94]
synonym: "S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase activity" EXACT [EC:2.1.1.94]
synonym: "S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase activity" EXACT [EC:2.1.1.94]
synonym: "tabersonine 16-O-methyltransferase activity" EXACT [EC:2.1.1.94]
xref: EC:2.1.1.94
xref: MetaCyc:2.1.1.94-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030767
name: 3-hydroxyanthranilate 4-C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hydroxyanthranilate = S-adenosyl-L-homocysteine + 3-hydroxy-4-methylanthranilate." [EC:2.1.1.97]
synonym: "3-hydroxyanthranilate 4-methyltransferase activity" EXACT [EC:2.1.1.97]
synonym: "S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase activity" EXACT [EC:2.1.1.97]
xref: EC:2.1.1.97
xref: MetaCyc:2.1.1.97-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030768
name: 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxy-tabersonine = S-adenosyl-L-homocysteine + deacetoxyvindoline." [EC:2.1.1.99]
synonym: "16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase activity" EXACT [EC:2.1.1.99]
synonym: "3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99]
synonym: "NMT activity" EXACT [EC:2.1.1.99]
synonym: "S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99]
synonym: "S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99]
xref: EC:2.1.1.99
xref: MetaCyc:2.1.1.99-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030769
name: macrocin O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + macrocin = S-adenosyl-L-homocysteine + tylosin." [EC:2.1.1.101]
subset: gosubset_prok
synonym: "macrocin methyltransferase activity" EXACT [EC:2.1.1.101]
synonym: "S-adenosyl-L-methionine-macrocin O-methyltransferase activity" EXACT [EC:2.1.1.101]
synonym: "S-adenosyl-L-methionine:macrocin 3'''-O-methyltransferase activity" EXACT [EC:2.1.1.101]
xref: EC:2.1.1.101
xref: MetaCyc:MACROCIN-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030770
name: demethylmacrocin O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + demethylmacrocin = S-adenosyl-L-homocysteine + macrocin." [EC:2.1.1.102]
synonym: "demethylmacrocin methyltransferase activity" EXACT [EC:2.1.1.102]
synonym: "S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase activity" EXACT [EC:2.1.1.102]
xref: EC:2.1.1.102
xref: MetaCyc:DEMETHYLMACROCIN-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030771
name: N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-benzoyl-4-hydroxyanthranilate = S-adenosyl-L-homocysteine + N-benzoyl-4-methoxyanthranilate." [EC:2.1.1.105]
synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.1.1.105]
synonym: "N-benzoyl-4-hydroxyanthranilate 4-methyltransferase activity" EXACT [EC:2.1.1.105]
synonym: "S-adenosyl-L-methionine:N-benzoyl-4-O-hydroxyanthranilate 4-O-methyltransferase activity" EXACT [EC:2.1.1.105]
xref: EC:2.1.1.105
xref: MetaCyc:2.1.1.105-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030772
name: tryptophan 2-C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan." [EC:2.1.1.106]
synonym: "S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase activity" EXACT [EC:2.1.1.106]
synonym: "S-adenosylmethionine:tryptophan 2-methyltransferase activity" EXACT [EC:2.1.1.106]
synonym: "tryptophan 2-methyltransferase activity" EXACT [EC:2.1.1.106]
xref: EC:2.1.1.106
xref: MetaCyc:TRYPTOPHAN-2-C-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030773
name: 6-hydroxymellein O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 6-hydroxymellein = S-adenosyl-L-homocysteine + 6-methoxymellein." [EC:2.1.1.108]
synonym: "6-hydroxymellein methyltransferase activity" EXACT [EC:2.1.1.108]
synonym: "S-adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase activity" EXACT [EC:2.1.1.108]
xref: EC:2.1.1.108
xref: MetaCyc:6-HYDROXYMELLEIN-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030774
name: anthranilate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = S-adenosyl-L-homocysteine + N-methylanthranilate." [EC:2.1.1.111]
synonym: "anthranilic acid N-methyltransferase activity" EXACT [EC:2.1.1.111]
synonym: "S-adenosyl-L-methionine:anthranilate N-methyltransferase activity" EXACT [EC:2.1.1.111]
xref: EC:2.1.1.111
xref: MetaCyc:ANTHRANILATE-N-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030775
name: glucuronoxylan 4-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate." [EC:2.1.1.112]
synonym: "S-adenosyl-L-methionine:glucuronoxylan-D-glucuronate 4-O-methyltransferase activity" EXACT [EC:2.1.1.112]
xref: EC:2.1.1.112
xref: MetaCyc:GLUCURONOXYLAN-4-O-METHYLTRANSFERASE-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030776
name: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline." [EC:2.1.1.115]
synonym: "(RS)-tetrahydrobenzylisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115]
synonym: "(rs)-tetrahydrobenzylisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115]
synonym: "norreticuline N-methyltransferase activity" EXACT [EC:2.1.1.115]
synonym: "S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115]
xref: EC:2.1.1.115
xref: MetaCyc:2.1.1.115-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030777
name: (S)-scoulerine 9-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-scoulerine = S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine." [EC:2.1.1.117]
synonym: "S-adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase activity" EXACT [EC:2.1.1.117]
synonym: "S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase activity" EXACT [EC:2.1.1.117]
xref: EC:2.1.1.117
xref: MetaCyc:2.1.1.117-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030778
name: columbamine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + palmatine." [EC:2.1.1.118]
synonym: "S-adenosyl-L-methionine:columbamine O-methyltransferase activity" EXACT [EC:2.1.1.118]
xref: EC:2.1.1.118
xref: MetaCyc:2.1.1.118-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030779
name: 10-hydroxydihydrosanguinarine 10-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 10-hydroxydihydrosanguinarine = S-adenosyl-L-homocysteine + dihydrochelirubine." [EC:2.1.1.119]
synonym: "S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase activity" EXACT [EC:2.1.1.119]
xref: EC:2.1.1.119
xref: MetaCyc:2.1.1.119-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030780
name: 12-hydroxydihydrochelirubine 12-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine = S-adenosyl-L-homocysteine + dihydromacarpine." [EC:2.1.1.120]
synonym: "S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase activity" EXACT [EC:2.1.1.120]
xref: EC:2.1.1.120
xref: MetaCyc:2.1.1.120-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030781
name: 6-O-methylnorlaudanosoline 5'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline." [EC:2.1.1.121]
synonym: "S-adenosyl-L-methionine:6-O-methylnorlaudanosoline 5'-O-methyltransferase activity" EXACT [EC:2.1.1.121]
xref: EC:2.1.1.121
xref: MetaCyc:2.1.1.121-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030782
name: (S)-tetrahydroprotoberberine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine." [EC:2.1.1.122]
synonym: "S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase activity" EXACT [EC:2.1.1.122]
synonym: "tetrahydroprotoberberine cis-N-methyltransferase activity" EXACT [EC:2.1.1.122]
xref: EC:2.1.1.122
xref: MetaCyc:2.1.1.122-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030783
name: [cytochrome c]-methionine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine." [EC:2.1.1.123]
synonym: "cytochrome c-methionine S-methyltransferase activity" EXACT [EC:2.1.1.123]
synonym: "S-adenosyl-L-methionine:cytochrome c-methionine S-methyltransferase activity" EXACT [EC:2.1.1.123]
xref: EC:2.1.1.123
xref: MetaCyc:2.1.1.123-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030784
name: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline." [EC:2.1.1.116]
synonym: "S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity" EXACT [EC:2.1.1.116]
xref: EC:2.1.1.116
xref: MetaCyc:2.1.1.116-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030785
name: [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine." [EC:2.1.1.127]
synonym: "ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilonN-methyltransferase activity" EXACT [EC:2.1.1.127]
synonym: "ribulose-bisphosphate carboxylase-lysine N-methyltransferase activity" EXACT [EC:2.1.1.127]
synonym: "ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase activity" EXACT [EC:2.1.1.127]
synonym: "RuBisCO LSMT activity" EXACT [EC:2.1.1.127]
synonym: "rubisco methyltransferase activity" EXACT [EC:2.1.1.127]
synonym: "RuBisCO methyltransferase activity" EXACT [EC:2.1.1.127]
synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.127]
synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.127]
xref: EC:2.1.1.127
xref: MetaCyc:2.1.1.127-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030786
name: (RS)-norcoclaurine 6-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine." [EC:2.1.1.128]
synonym: "S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase activity" EXACT [EC:2.1.1.128]
xref: EC:2.1.1.128
xref: MetaCyc:2.1.1.128-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030787
name: inositol 4-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + myo-inositol = S-adenosyl-L-homocysteine + 4-methyl-myo-inositol." [EC:2.1.1.129]
synonym: "myo-inositol 4-O-methyltransferase activity" EXACT [EC:2.1.1.129]
synonym: "myo-inositol 6-O-methyltransferase activity" RELATED [EC:2.1.1.129]
synonym: "S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase activity" EXACT [EC:2.1.1.129]
synonym: "S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase activity" EXACT [EC:2.1.1.129]
xref: EC:2.1.1.129
xref: MetaCyc:2.1.1.129-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030788
name: precorrin-2 C20-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + precorrin-3A." [EC:2.1.1.130]
subset: gosubset_prok
synonym: "S-adenosyl-L-methionine--precorrin-2 methyltransferase activity" EXACT [EC:2.1.1.130]
synonym: "S-adenosyl-L-methionine:precorrin-4 C20-methyltransferase activity" EXACT [EC:2.1.1.130]
xref: EC:2.1.1.130
xref: MetaCyc:2.1.1.130-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030789
name: precorrin-3B C17-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4." [EC:2.1.1.131]
subset: gosubset_prok
synonym: "CobJ" RELATED [EC:2.1.1.131]
synonym: "precorrin-3 methylase activity" EXACT [EC:2.1.1.131]
synonym: "precorrin-3 methyltransferase activity" EXACT [EC:2.1.1.131]
synonym: "S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase activity" EXACT [EC:2.1.1.131]
xref: EC:2.1.1.131
xref: MetaCyc:2.1.1.131-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030790
name: chlorophenol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole." [EC:2.1.1.136]
synonym: "halogenated phenol O-methyltransferase activity" BROAD [EC:2.1.1.136]
synonym: "S-adenosyl-L-methionine:trichlorophenol O-methyltransferase activity" EXACT [EC:2.1.1.136]
synonym: "trichlorophenol O-methyltransferase activity" EXACT [EC:2.1.1.136]
xref: EC:2.1.1.136
xref: MetaCyc:2.1.1.136-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030791
name: arsenite methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate." [EC:2.1.1.137]
comment: Note that the enzyme arsenite methyltransferase also has methylarsonite methyltransferase activity (GO:0030792).
synonym: "S-adenosyl-L-methionine:arsenic(III) methyltransferase activity" EXACT [EC:2.1.1.137]
synonym: "S-adenosyl-L-methionine:arsenite As-methyltransferase activity" EXACT [EC:2.1.1.137]
synonym: "S-adenosyl-L-methionine:methylarsonite As-methyltransferase activity" EXACT [EC:2.1.1.137]
xref: EC:2.1.1.137
xref: MetaCyc:2.1.1.137-RXN
xref: UM-BBD_enzymeID:e0515
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030792
name: methylarsonite methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate." [EC:2.1.1.138]
comment: Note that EC:2.1.1.138 was deleted from EC as the reaction is performed by arsenite methyltransferase (EC:2.1.1.137).
xref: EC:2.1.1.-
xref: MetaCyc:2.1.1.138-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030793
name: 3'-demethylstaurosporine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-demethylstaurosporine = S-adenosyl-L-homocysteine + staurosporine." [EC:2.1.1.139]
synonym: "3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase activity" EXACT [EC:2.1.1.139]
synonym: "S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase activity" EXACT [EC:2.1.1.139]
synonym: "staurosporine synthase activity" EXACT [EC:2.1.1.139]
xref: EC:2.1.1.139
xref: MetaCyc:2.1.1.139-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030794
name: (S)-coclaurine-N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine." [EC:2.1.1.140]
synonym: "S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase activity" EXACT [EC:2.1.1.140]
xref: EC:2.1.1.140
xref: MetaCyc:2.1.1.140-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030795
name: jasmonate O-methyltransferase activity
namespace: molecular_function
alt_id: GO:0045546
def: "Catalysis of the reaction: S-adenosyl-L-methionine + jasmonate = S-adenosyl-L-homocysteine + methyljasmonate." [EC:2.1.1.141]
synonym: "jasmonic acid carboxyl methyltransferase activity" EXACT [EC:2.1.1.141]
synonym: "S-adenosyl-L-methionine:jasmonate O-methyltransferase activity" EXACT [EC:2.1.1.141]
synonym: "S-adenosyl-L-methionine:jasmonic acid carboxyl methyltransferase activity" EXACT []
xref: EC:2.1.1.141
xref: MetaCyc:RXN1F-28
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030796
name: cycloartenol 24-C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = S-adenosyl-L-homocysteine + (24R)-24-methylcycloarta-8,25-dien-3N2-ol." [EC:2.1.1.142]
synonym: "S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase activity" EXACT [EC:2.1.1.142]
synonym: "sterol C-methyltransferase activity" BROAD [EC:2.1.1.142]
xref: EC:2.1.1.142
xref: MetaCyc:2.1.1.142-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030797
name: 24-methylenesterol C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 24-methylenelophenol = S-adenosyl-L-homocysteine + (Z)-24-ethylidenelophenol." [EC:2.1.1.143]
synonym: "24-methylenelophenol C-24(1)-methyltransferase activity" EXACT [EC:2.1.1.143]
synonym: "24-methylenelophenol C-241-methyltransferase activity" EXACT [EC:2.1.1.143]
synonym: "S-adenosyl-L-methionine:24-methylenelophenol C-methyltransferase activity" EXACT [EC:2.1.1.143]
synonym: "SMT(2) activity" NARROW [EC:2.1.1.143]
synonym: "SMT2" RELATED [EC:2.1.1.143]
xref: EC:2.1.1.143
xref: MetaCyc:2.1.1.143-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030798
name: trans-aconitate 2-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate." [EC:2.1.1.144]
subset: gosubset_prok
synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2'-O-methyltransferase activity" EXACT [EC:2.1.1.144]
xref: EC:2.1.1.144
xref: MetaCyc:RXN0-2441
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0030799
name: regulation of cyclic nucleotide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cyclic nucleotide metabolism" EXACT []
is_a: GO:0006140 ! regulation of nucleotide metabolic process
relationship: regulates GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0030800
name: negative regulation of cyclic nucleotide metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cyclic nucleotide metabolic process" EXACT []
synonym: "down-regulation of cyclic nucleotide metabolic process" EXACT []
synonym: "downregulation of cyclic nucleotide metabolic process" EXACT []
synonym: "inhibition of cyclic nucleotide metabolic process" NARROW []
synonym: "negative regulation of cyclic nucleotide metabolism" EXACT []
is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process
is_a: GO:0045980 ! negative regulation of nucleotide metabolic process
relationship: negatively_regulates GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0030801
name: positive regulation of cyclic nucleotide metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cyclic nucleotide metabolic process" NARROW []
synonym: "positive regulation of cyclic nucleotide metabolism" EXACT []
synonym: "stimulation of cyclic nucleotide metabolic process" NARROW []
synonym: "up regulation of cyclic nucleotide metabolic process" EXACT []
synonym: "up-regulation of cyclic nucleotide metabolic process" EXACT []
synonym: "upregulation of cyclic nucleotide metabolic process" EXACT []
is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process
is_a: GO:0045981 ! positive regulation of nucleotide metabolic process
relationship: positively_regulates GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0030802
name: regulation of cyclic nucleotide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cyclic nucleotide anabolism" EXACT []
synonym: "regulation of cyclic nucleotide biosynthesis" EXACT []
synonym: "regulation of cyclic nucleotide formation" EXACT []
synonym: "regulation of cyclic nucleotide synthesis" EXACT []
is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process
is_a: GO:0030808 ! regulation of nucleotide biosynthetic process
relationship: regulates GO:0009190 ! cyclic nucleotide biosynthetic process

[Term]
id: GO:0030803
name: negative regulation of cyclic nucleotide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cyclic nucleotide biosynthetic process" EXACT []
synonym: "down-regulation of cyclic nucleotide biosynthetic process" EXACT []
synonym: "downregulation of cyclic nucleotide biosynthetic process" EXACT []
synonym: "inhibition of cyclic nucleotide biosynthetic process" NARROW []
synonym: "negative regulation of cyclic nucleotide anabolism" EXACT []
synonym: "negative regulation of cyclic nucleotide biosynthesis" EXACT []
synonym: "negative regulation of cyclic nucleotide formation" EXACT []
synonym: "negative regulation of cyclic nucleotide synthesis" EXACT []
is_a: GO:0030800 ! negative regulation of cyclic nucleotide metabolic process
is_a: GO:0030802 ! regulation of cyclic nucleotide biosynthetic process
is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process
relationship: negatively_regulates GO:0009190 ! cyclic nucleotide biosynthetic process

[Term]
id: GO:0030804
name: positive regulation of cyclic nucleotide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cyclic nucleotide biosynthetic process" NARROW []
synonym: "positive regulation of cyclic nucleotide anabolism" EXACT []
synonym: "positive regulation of cyclic nucleotide biosynthesis" EXACT []
synonym: "positive regulation of cyclic nucleotide formation" EXACT []
synonym: "positive regulation of cyclic nucleotide synthesis" EXACT []
synonym: "stimulation of cyclic nucleotide biosynthetic process" NARROW []
synonym: "up regulation of cyclic nucleotide biosynthetic process" EXACT []
synonym: "up-regulation of cyclic nucleotide biosynthetic process" EXACT []
synonym: "upregulation of cyclic nucleotide biosynthetic process" EXACT []
is_a: GO:0030801 ! positive regulation of cyclic nucleotide metabolic process
is_a: GO:0030802 ! regulation of cyclic nucleotide biosynthetic process
is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process
relationship: positively_regulates GO:0009190 ! cyclic nucleotide biosynthetic process

[Term]
id: GO:0030805
name: regulation of cyclic nucleotide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cyclic nucleotide breakdown" EXACT []
synonym: "regulation of cyclic nucleotide catabolism" EXACT []
synonym: "regulation of cyclic nucleotide degradation" EXACT []
is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process
is_a: GO:0030811 ! regulation of nucleotide catabolic process
relationship: regulates GO:0009214 ! cyclic nucleotide catabolic process

[Term]
id: GO:0030806
name: negative regulation of cyclic nucleotide catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cyclic nucleotide catabolic process" EXACT []
synonym: "down-regulation of cyclic nucleotide catabolic process" EXACT []
synonym: "downregulation of cyclic nucleotide catabolic process" EXACT []
synonym: "inhibition of cyclic nucleotide catabolic process" NARROW []
synonym: "negative regulation of cyclic nucleotide breakdown" EXACT []
synonym: "negative regulation of cyclic nucleotide catabolism" EXACT []
synonym: "negative regulation of cyclic nucleotide degradation" EXACT []
is_a: GO:0030800 ! negative regulation of cyclic nucleotide metabolic process
is_a: GO:0030805 ! regulation of cyclic nucleotide catabolic process
is_a: GO:0030812 ! negative regulation of nucleotide catabolic process
relationship: negatively_regulates GO:0009214 ! cyclic nucleotide catabolic process

[Term]
id: GO:0030807
name: positive regulation of cyclic nucleotide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cyclic nucleotide catabolic process" NARROW []
synonym: "positive regulation of cyclic nucleotide breakdown" EXACT []
synonym: "positive regulation of cyclic nucleotide catabolism" EXACT []
synonym: "positive regulation of cyclic nucleotide degradation" EXACT []
synonym: "stimulation of cyclic nucleotide catabolic process" NARROW []
synonym: "up regulation of cyclic nucleotide catabolic process" EXACT []
synonym: "up-regulation of cyclic nucleotide catabolic process" EXACT []
synonym: "upregulation of cyclic nucleotide catabolic process" EXACT []
is_a: GO:0030801 ! positive regulation of cyclic nucleotide metabolic process
is_a: GO:0030805 ! regulation of cyclic nucleotide catabolic process
is_a: GO:0030813 ! positive regulation of nucleotide catabolic process
relationship: positively_regulates GO:0009214 ! cyclic nucleotide catabolic process

[Term]
id: GO:0030808
name: regulation of nucleotide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of nucleotide anabolism" EXACT []
synonym: "regulation of nucleotide biosynthesis" EXACT []
synonym: "regulation of nucleotide formation" EXACT []
synonym: "regulation of nucleotide synthesis" EXACT []
is_a: GO:0006140 ! regulation of nucleotide metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
relationship: regulates GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0030809
name: negative regulation of nucleotide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of nucleotide biosynthetic process" EXACT []
synonym: "down-regulation of nucleotide biosynthetic process" EXACT []
synonym: "downregulation of nucleotide biosynthetic process" EXACT []
synonym: "inhibition of nucleotide biosynthetic process" NARROW []
synonym: "negative regulation of nucleotide anabolism" EXACT []
synonym: "negative regulation of nucleotide biosynthesis" EXACT []
synonym: "negative regulation of nucleotide formation" EXACT []
synonym: "negative regulation of nucleotide synthesis" EXACT []
is_a: GO:0030808 ! regulation of nucleotide biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045980 ! negative regulation of nucleotide metabolic process
relationship: negatively_regulates GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0030810
name: positive regulation of nucleotide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "activation of nucleotide biosynthetic process" NARROW []
synonym: "positive regulation of nucleotide anabolism" EXACT []
synonym: "positive regulation of nucleotide biosynthesis" EXACT []
synonym: "positive regulation of nucleotide formation" EXACT []
synonym: "positive regulation of nucleotide synthesis" EXACT []
synonym: "stimulation of nucleotide biosynthetic process" NARROW []
synonym: "up regulation of nucleotide biosynthetic process" EXACT []
synonym: "up-regulation of nucleotide biosynthetic process" EXACT []
synonym: "upregulation of nucleotide biosynthetic process" EXACT []
is_a: GO:0030808 ! regulation of nucleotide biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045981 ! positive regulation of nucleotide metabolic process
relationship: positively_regulates GO:0009165 ! nucleotide biosynthetic process

[Term]
id: GO:0030811
name: regulation of nucleotide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of nucleotide breakdown" EXACT []
synonym: "regulation of nucleotide catabolism" EXACT []
synonym: "regulation of nucleotide degradation" EXACT []
is_a: GO:0006140 ! regulation of nucleotide metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
relationship: regulates GO:0009166 ! nucleotide catabolic process

[Term]
id: GO:0030812
name: negative regulation of nucleotide catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of nucleotide catabolic process" EXACT []
synonym: "down-regulation of nucleotide catabolic process" EXACT []
synonym: "downregulation of nucleotide catabolic process" EXACT []
synonym: "inhibition of nucleotide catabolic process" NARROW []
synonym: "negative regulation of nucleotide breakdown" EXACT []
synonym: "negative regulation of nucleotide catabolism" EXACT []
synonym: "negative regulation of nucleotide degradation" EXACT []
is_a: GO:0030811 ! regulation of nucleotide catabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0045980 ! negative regulation of nucleotide metabolic process
relationship: negatively_regulates GO:0009166 ! nucleotide catabolic process

[Term]
id: GO:0030813
name: positive regulation of nucleotide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah]
subset: gosubset_prok
synonym: "activation of nucleotide catabolic process" NARROW []
synonym: "positive regulation of nucleotide breakdown" EXACT []
synonym: "positive regulation of nucleotide catabolism" EXACT []
synonym: "positive regulation of nucleotide degradation" EXACT []
synonym: "stimulation of nucleotide catabolic process" NARROW []
synonym: "up regulation of nucleotide catabolic process" EXACT []
synonym: "up-regulation of nucleotide catabolic process" EXACT []
synonym: "upregulation of nucleotide catabolic process" EXACT []
is_a: GO:0030811 ! regulation of nucleotide catabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0045981 ! positive regulation of nucleotide metabolic process
relationship: positively_regulates GO:0009166 ! nucleotide catabolic process

[Term]
id: GO:0030814
name: regulation of cAMP metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of 3',5' cAMP metabolic process" EXACT []
synonym: "regulation of 3',5' cAMP metabolism" EXACT []
synonym: "regulation of 3',5'-cAMP metabolic process" EXACT []
synonym: "regulation of 3',5'-cAMP metabolism" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT []
synonym: "regulation of cAMP metabolism" EXACT []
synonym: "regulation of cyclic AMP metabolic process" EXACT []
synonym: "regulation of cyclic AMP metabolism" EXACT []
is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process
relationship: regulates GO:0046058 ! cAMP metabolic process

[Term]
id: GO:0030815
name: negative regulation of cAMP metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cAMP metabolic process" EXACT []
synonym: "down-regulation of cAMP metabolic process" EXACT []
synonym: "downregulation of cAMP metabolic process" EXACT []
synonym: "inhibition of cAMP metabolic process" NARROW []
synonym: "negative regulation of 3',5' cAMP metabolic process" EXACT []
synonym: "negative regulation of 3',5' cAMP metabolism" EXACT []
synonym: "negative regulation of 3',5'-cAMP metabolic process" EXACT []
synonym: "negative regulation of 3',5'-cAMP metabolism" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT []
synonym: "negative regulation of cAMP metabolism" EXACT []
synonym: "negative regulation of cyclic AMP metabolic process" EXACT []
synonym: "negative regulation of cyclic AMP metabolism" EXACT []
is_a: GO:0030800 ! negative regulation of cyclic nucleotide metabolic process
is_a: GO:0030814 ! regulation of cAMP metabolic process
relationship: negatively_regulates GO:0046058 ! cAMP metabolic process

[Term]
id: GO:0030816
name: positive regulation of cAMP metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cAMP metabolic process" NARROW []
synonym: "positive regulation of 3',5' cAMP metabolic process" EXACT []
synonym: "positive regulation of 3',5' cAMP metabolism" EXACT []
synonym: "positive regulation of 3',5'-cAMP metabolic process" EXACT []
synonym: "positive regulation of 3',5'-cAMP metabolism" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT []
synonym: "positive regulation of cAMP metabolism" EXACT []
synonym: "positive regulation of cyclic AMP metabolic process" EXACT []
synonym: "positive regulation of cyclic AMP metabolism" EXACT []
synonym: "stimulation of cAMP metabolic process" NARROW []
synonym: "up regulation of cAMP metabolic process" EXACT []
synonym: "up-regulation of cAMP metabolic process" EXACT []
synonym: "upregulation of cAMP metabolic process" EXACT []
is_a: GO:0030801 ! positive regulation of cyclic nucleotide metabolic process
is_a: GO:0030814 ! regulation of cAMP metabolic process
relationship: positively_regulates GO:0046058 ! cAMP metabolic process

[Term]
id: GO:0030817
name: regulation of cAMP biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of 3',5' cAMP biosynthesis" EXACT []
synonym: "regulation of 3',5' cAMP biosynthetic process" EXACT []
synonym: "regulation of 3',5'-cAMP biosynthesis" EXACT []
synonym: "regulation of 3',5'-cAMP biosynthetic process" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT []
synonym: "regulation of cAMP anabolism" EXACT []
synonym: "regulation of cAMP biosynthesis" EXACT []
synonym: "regulation of cAMP formation" EXACT []
synonym: "regulation of cAMP synthesis" EXACT []
synonym: "regulation of cyclic AMP biosynthesis" EXACT []
synonym: "regulation of cyclic AMP biosynthetic process" EXACT []
is_a: GO:0030802 ! regulation of cyclic nucleotide biosynthetic process
is_a: GO:0030814 ! regulation of cAMP metabolic process
relationship: regulates GO:0006171 ! cAMP biosynthetic process

[Term]
id: GO:0030818
name: negative regulation of cAMP biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cAMP biosynthetic process" EXACT []
synonym: "down-regulation of cAMP biosynthetic process" EXACT []
synonym: "downregulation of cAMP biosynthetic process" EXACT []
synonym: "inhibition of cAMP biosynthetic process" NARROW []
synonym: "negative regulation of 3',5' cAMP biosynthesis" EXACT []
synonym: "negative regulation of 3',5' cAMP biosynthetic process" EXACT []
synonym: "negative regulation of 3',5'-cAMP biosynthesis" EXACT []
synonym: "negative regulation of 3',5'-cAMP biosynthetic process" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT []
synonym: "negative regulation of cAMP anabolism" EXACT []
synonym: "negative regulation of cAMP biosynthesis" EXACT []
synonym: "negative regulation of cAMP formation" EXACT []
synonym: "negative regulation of cAMP synthesis" EXACT []
synonym: "negative regulation of cyclic AMP biosynthesis" EXACT []
synonym: "negative regulation of cyclic AMP biosynthetic process" EXACT []
is_a: GO:0030803 ! negative regulation of cyclic nucleotide biosynthetic process
is_a: GO:0030815 ! negative regulation of cAMP metabolic process
is_a: GO:0030817 ! regulation of cAMP biosynthetic process
relationship: negatively_regulates GO:0006171 ! cAMP biosynthetic process

[Term]
id: GO:0030819
name: positive regulation of cAMP biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cAMP biosynthetic process" NARROW []
synonym: "positive regulation of 3',5' cAMP biosynthesis" EXACT []
synonym: "positive regulation of 3',5' cAMP biosynthetic process" EXACT []
synonym: "positive regulation of 3',5'-cAMP biosynthesis" EXACT []
synonym: "positive regulation of 3',5'-cAMP biosynthetic process" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT []
synonym: "positive regulation of cAMP anabolism" EXACT []
synonym: "positive regulation of cAMP biosynthesis" EXACT []
synonym: "positive regulation of cAMP formation" EXACT []
synonym: "positive regulation of cAMP synthesis" EXACT []
synonym: "positive regulation of cyclic AMP biosynthesis" EXACT []
synonym: "positive regulation of cyclic AMP biosynthetic process" EXACT []
synonym: "stimulation of cAMP biosynthetic process" NARROW []
synonym: "up regulation of cAMP biosynthetic process" EXACT []
synonym: "up-regulation of cAMP biosynthetic process" EXACT []
synonym: "upregulation of cAMP biosynthetic process" EXACT []
is_a: GO:0030804 ! positive regulation of cyclic nucleotide biosynthetic process
is_a: GO:0030816 ! positive regulation of cAMP metabolic process
is_a: GO:0030817 ! regulation of cAMP biosynthetic process
relationship: positively_regulates GO:0006171 ! cAMP biosynthetic process

[Term]
id: GO:0030820
name: regulation of cAMP catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of 3',5' cAMP catabolic process" EXACT []
synonym: "regulation of 3',5' cAMP catabolism" EXACT []
synonym: "regulation of 3',5'-cAMP catabolic process" EXACT []
synonym: "regulation of 3',5'-cAMP catabolism" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT []
synonym: "regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT []
synonym: "regulation of cAMP breakdown" EXACT []
synonym: "regulation of cAMP catabolism" EXACT []
synonym: "regulation of cAMP degradation" EXACT []
synonym: "regulation of cyclic AMP catabolic process" EXACT []
synonym: "regulation of cyclic AMP catabolism" EXACT []
is_a: GO:0030805 ! regulation of cyclic nucleotide catabolic process
is_a: GO:0030814 ! regulation of cAMP metabolic process
is_a: GO:0033121 ! regulation of purine nucleotide catabolic process
relationship: regulates GO:0006198 ! cAMP catabolic process

[Term]
id: GO:0030821
name: negative regulation of cAMP catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cAMP catabolic process" EXACT []
synonym: "down-regulation of cAMP catabolic process" EXACT []
synonym: "downregulation of cAMP catabolic process" EXACT []
synonym: "inhibition of cAMP catabolic process" NARROW []
synonym: "negative regulation of 3',5' cAMP catabolic process" EXACT []
synonym: "negative regulation of 3',5' cAMP catabolism" EXACT []
synonym: "negative regulation of 3',5'-cAMP catabolic process" EXACT []
synonym: "negative regulation of 3',5'-cAMP catabolism" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT []
synonym: "negative regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT []
synonym: "negative regulation of cAMP breakdown" EXACT []
synonym: "negative regulation of cAMP catabolism" EXACT []
synonym: "negative regulation of cAMP degradation" EXACT []
synonym: "negative regulation of cyclic AMP catabolic process" EXACT []
synonym: "negative regulation of cyclic AMP catabolism" EXACT []
is_a: GO:0030806 ! negative regulation of cyclic nucleotide catabolic process
is_a: GO:0030815 ! negative regulation of cAMP metabolic process
is_a: GO:0030820 ! regulation of cAMP catabolic process
is_a: GO:0033122 ! negative regulation of purine nucleotide catabolic process
relationship: negatively_regulates GO:0006198 ! cAMP catabolic process

[Term]
id: GO:0030822
name: positive regulation of cAMP catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cAMP catabolic process" NARROW []
synonym: "positive regulation of 3',5' cAMP catabolic process" EXACT []
synonym: "positive regulation of 3',5' cAMP catabolism" EXACT []
synonym: "positive regulation of 3',5'-cAMP catabolic process" EXACT []
synonym: "positive regulation of 3',5'-cAMP catabolism" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT []
synonym: "positive regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT []
synonym: "positive regulation of cAMP breakdown" EXACT []
synonym: "positive regulation of cAMP catabolism" EXACT []
synonym: "positive regulation of cAMP degradation" EXACT []
synonym: "positive regulation of cyclic AMP catabolic process" EXACT []
synonym: "positive regulation of cyclic AMP catabolism" EXACT []
synonym: "stimulation of cAMP catabolic process" NARROW []
synonym: "up regulation of cAMP catabolic process" EXACT []
synonym: "up-regulation of cAMP catabolic process" EXACT []
synonym: "upregulation of cAMP catabolic process" EXACT []
is_a: GO:0030807 ! positive regulation of cyclic nucleotide catabolic process
is_a: GO:0030816 ! positive regulation of cAMP metabolic process
is_a: GO:0030820 ! regulation of cAMP catabolic process
is_a: GO:0033123 ! positive regulation of purine nucleotide catabolic process
relationship: positively_regulates GO:0006198 ! cAMP catabolic process

[Term]
id: GO:0030823
name: regulation of cGMP metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cGMP metabolism" EXACT []
is_a: GO:0030799 ! regulation of cyclic nucleotide metabolic process
relationship: regulates GO:0046068 ! cGMP metabolic process

[Term]
id: GO:0030824
name: negative regulation of cGMP metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cGMP metabolic process" EXACT []
synonym: "down-regulation of cGMP metabolic process" EXACT []
synonym: "downregulation of cGMP metabolic process" EXACT []
synonym: "inhibition of cGMP metabolic process" NARROW []
synonym: "negative regulation of cGMP metabolism" EXACT []
is_a: GO:0030800 ! negative regulation of cyclic nucleotide metabolic process
is_a: GO:0030823 ! regulation of cGMP metabolic process
relationship: negatively_regulates GO:0046068 ! cGMP metabolic process

[Term]
id: GO:0030825
name: positive regulation of cGMP metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cGMP metabolic process" NARROW []
synonym: "positive regulation of cGMP metabolism" EXACT []
synonym: "stimulation of cGMP metabolic process" NARROW []
synonym: "up regulation of cGMP metabolic process" EXACT []
synonym: "up-regulation of cGMP metabolic process" EXACT []
synonym: "upregulation of cGMP metabolic process" EXACT []
is_a: GO:0030801 ! positive regulation of cyclic nucleotide metabolic process
is_a: GO:0030823 ! regulation of cGMP metabolic process
relationship: positively_regulates GO:0046068 ! cGMP metabolic process

[Term]
id: GO:0030826
name: regulation of cGMP biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cGMP anabolism" EXACT []
synonym: "regulation of cGMP biosynthesis" EXACT []
synonym: "regulation of cGMP formation" EXACT []
synonym: "regulation of cGMP synthesis" EXACT []
is_a: GO:0030802 ! regulation of cyclic nucleotide biosynthetic process
is_a: GO:0030823 ! regulation of cGMP metabolic process
relationship: regulates GO:0006182 ! cGMP biosynthetic process

[Term]
id: GO:0030827
name: negative regulation of cGMP biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cGMP biosynthetic process" EXACT []
synonym: "down-regulation of cGMP biosynthetic process" EXACT []
synonym: "downregulation of cGMP biosynthetic process" EXACT []
synonym: "inhibition of cGMP biosynthetic process" NARROW []
synonym: "negative regulation of cGMP anabolism" EXACT []
synonym: "negative regulation of cGMP biosynthesis" EXACT []
synonym: "negative regulation of cGMP formation" EXACT []
synonym: "negative regulation of cGMP synthesis" EXACT []
is_a: GO:0030803 ! negative regulation of cyclic nucleotide biosynthetic process
is_a: GO:0030824 ! negative regulation of cGMP metabolic process
is_a: GO:0030826 ! regulation of cGMP biosynthetic process
relationship: negatively_regulates GO:0006182 ! cGMP biosynthetic process

[Term]
id: GO:0030828
name: positive regulation of cGMP biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cGMP biosynthetic process" NARROW []
synonym: "positive regulation of cGMP anabolism" EXACT []
synonym: "positive regulation of cGMP biosynthesis" EXACT []
synonym: "positive regulation of cGMP formation" EXACT []
synonym: "positive regulation of cGMP synthesis" EXACT []
synonym: "stimulation of cGMP biosynthetic process" NARROW []
synonym: "up regulation of cGMP biosynthetic process" EXACT []
synonym: "up-regulation of cGMP biosynthetic process" EXACT []
synonym: "upregulation of cGMP biosynthetic process" EXACT []
is_a: GO:0030804 ! positive regulation of cyclic nucleotide biosynthetic process
is_a: GO:0030825 ! positive regulation of cGMP metabolic process
is_a: GO:0030826 ! regulation of cGMP biosynthetic process
relationship: positively_regulates GO:0006182 ! cGMP biosynthetic process

[Term]
id: GO:0030829
name: regulation of cGMP catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cGMP breakdown" EXACT []
synonym: "regulation of cGMP catabolism" EXACT []
synonym: "regulation of cGMP degradation" EXACT []
is_a: GO:0030805 ! regulation of cyclic nucleotide catabolic process
is_a: GO:0030823 ! regulation of cGMP metabolic process
is_a: GO:0033121 ! regulation of purine nucleotide catabolic process
relationship: regulates GO:0046069 ! cGMP catabolic process

[Term]
id: GO:0030830
name: negative regulation of cGMP catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cGMP catabolic process" EXACT []
synonym: "down-regulation of cGMP catabolic process" EXACT []
synonym: "downregulation of cGMP catabolic process" EXACT []
synonym: "inhibition of cGMP catabolic process" NARROW []
synonym: "negative regulation of cGMP breakdown" EXACT []
synonym: "negative regulation of cGMP catabolism" EXACT []
synonym: "negative regulation of cGMP degradation" EXACT []
is_a: GO:0030806 ! negative regulation of cyclic nucleotide catabolic process
is_a: GO:0030824 ! negative regulation of cGMP metabolic process
is_a: GO:0030829 ! regulation of cGMP catabolic process
is_a: GO:0033122 ! negative regulation of purine nucleotide catabolic process
relationship: negatively_regulates GO:0046069 ! cGMP catabolic process

[Term]
id: GO:0030831
name: positive regulation of cGMP catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cGMP catabolic process" NARROW []
synonym: "positive regulation of cGMP breakdown" EXACT []
synonym: "positive regulation of cGMP catabolism" EXACT []
synonym: "positive regulation of cGMP degradation" EXACT []
synonym: "stimulation of cGMP catabolic process" NARROW []
synonym: "up regulation of cGMP catabolic process" EXACT []
synonym: "up-regulation of cGMP catabolic process" EXACT []
synonym: "upregulation of cGMP catabolic process" EXACT []
is_a: GO:0030807 ! positive regulation of cyclic nucleotide catabolic process
is_a: GO:0030825 ! positive regulation of cGMP metabolic process
is_a: GO:0030829 ! regulation of cGMP catabolic process
is_a: GO:0033123 ! positive regulation of purine nucleotide catabolic process
relationship: positively_regulates GO:0046069 ! cGMP catabolic process

[Term]
id: GO:0030832
name: regulation of actin filament length
namespace: biological_process
def: "Any process that controls the length of actin filaments in a cell." [GOC:dph, GOC:mah]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0032535 ! regulation of cellular component size
is_a: GO:0032956 ! regulation of actin cytoskeleton organization

[Term]
id: GO:0030833
name: regulation of actin filament polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]
synonym: "regulation of actin polymerization" EXACT []
is_a: GO:0008064 ! regulation of actin polymerization or depolymerization
is_a: GO:0032271 ! regulation of protein polymerization
relationship: regulates GO:0030041 ! actin filament polymerization

[Term]
id: GO:0030834
name: regulation of actin filament depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]
synonym: "regulation of actin depolymerization" EXACT []
is_a: GO:0008064 ! regulation of actin polymerization or depolymerization
is_a: GO:0043244 ! regulation of protein complex disassembly
relationship: regulates GO:0030042 ! actin filament depolymerization

[Term]
id: GO:0030835
name: negative regulation of actin filament depolymerization
namespace: biological_process
alt_id: GO:0030044
def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin depolymerization." [GOC:mah]
comment: This term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin polymerization ; GO:0030837').
synonym: "actin filament stabilization" EXACT []
synonym: "down regulation of actin filament depolymerization" EXACT []
synonym: "down-regulation of actin filament depolymerization" EXACT []
synonym: "downregulation of actin filament depolymerization" EXACT []
synonym: "inhibition of actin filament depolymerization" NARROW []
synonym: "negative regulation of actin depolymerization" EXACT []
synonym: "negative regulation of actin polymerization and/or depolymerization" BROAD []
is_a: GO:0030834 ! regulation of actin filament depolymerization
is_a: GO:0043242 ! negative regulation of protein complex disassembly
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
relationship: negatively_regulates GO:0030042 ! actin filament depolymerization

[Term]
id: GO:0030836
name: positive regulation of actin filament depolymerization
namespace: biological_process
alt_id: GO:0030045
def: "Any process that activates or increases the frequency, rate or extent of actin depolymerization." [GOC:mah]
comment: This term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin polymerization ; GO:0030838').
synonym: "actin filament destabilization" EXACT []
synonym: "activation of actin filament depolymerization" NARROW []
synonym: "positive regulation of actin depolymerization" EXACT []
synonym: "positive regulation of actin polymerization and/or depolymerization" BROAD []
synonym: "stimulation of actin filament depolymerization" NARROW []
synonym: "up regulation of actin filament depolymerization" EXACT []
synonym: "up-regulation of actin filament depolymerization" EXACT []
synonym: "upregulation of actin filament depolymerization" EXACT []
is_a: GO:0030834 ! regulation of actin filament depolymerization
is_a: GO:0043243 ! positive regulation of protein complex disassembly
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
relationship: positively_regulates GO:0030042 ! actin filament depolymerization

[Term]
id: GO:0030837
name: negative regulation of actin filament polymerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]
comment: This term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin depolymerization ; GO:0030835').
synonym: "down regulation of actin filament polymerization" EXACT []
synonym: "down-regulation of actin filament polymerization" EXACT []
synonym: "downregulation of actin filament polymerization" EXACT []
synonym: "inhibition of actin filament polymerization" NARROW []
synonym: "negative regulation of actin polymerization" EXACT []
synonym: "negative regulation of actin polymerization and/or depolymerization" BROAD []
is_a: GO:0030833 ! regulation of actin filament polymerization
is_a: GO:0032272 ! negative regulation of protein polymerization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
relationship: negatively_regulates GO:0030041 ! actin filament polymerization

[Term]
id: GO:0030838
name: positive regulation of actin filament polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin polymerization." [GOC:mah]
comment: This term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin depolymerization ; GO:0030836').
synonym: "activation of actin filament polymerization" NARROW []
synonym: "positive regulation of actin polymerization" EXACT []
synonym: "positive regulation of actin polymerization and/or depolymerization" BROAD []
synonym: "stimulation of actin filament polymerization" NARROW []
synonym: "up regulation of actin filament polymerization" EXACT []
synonym: "up-regulation of actin filament polymerization" EXACT []
synonym: "upregulation of actin filament polymerization" EXACT []
is_a: GO:0030833 ! regulation of actin filament polymerization
is_a: GO:0032273 ! positive regulation of protein polymerization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
relationship: positively_regulates GO:0030041 ! actin filament polymerization

[Term]
id: GO:0030839
name: regulation of intermediate filament polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament." [GOC:mah]
is_a: GO:0032271 ! regulation of protein polymerization
is_a: GO:0045108 ! regulation of intermediate filament polymerization or depolymerization
relationship: regulates GO:0045107 ! intermediate filament polymerization

[Term]
id: GO:0030840
name: negative regulation of intermediate filament polymerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intermediate filament polymerization." [GOC:mah]
comment: This term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament depolymerization ; GO:0030843').
synonym: "down regulation of intermediate filament polymerization" EXACT []
synonym: "down-regulation of intermediate filament polymerization" EXACT []
synonym: "downregulation of intermediate filament polymerization" EXACT []
synonym: "inhibition of intermediate filament polymerization" NARROW []
synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" BROAD []
is_a: GO:0030839 ! regulation of intermediate filament polymerization
is_a: GO:0032272 ! negative regulation of protein polymerization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
relationship: negatively_regulates GO:0045107 ! intermediate filament polymerization

[Term]
id: GO:0030841
name: positive regulation of intermediate filament polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization." [GOC:mah]
comment: This term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament depolymerization ; GO:0030844').
synonym: "activation of intermediate filament polymerization" NARROW []
synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" BROAD []
synonym: "stimulation of intermediate filament polymerization" NARROW []
synonym: "up regulation of intermediate filament polymerization" EXACT []
synonym: "up-regulation of intermediate filament polymerization" EXACT []
synonym: "upregulation of intermediate filament polymerization" EXACT []
is_a: GO:0030839 ! regulation of intermediate filament polymerization
is_a: GO:0032273 ! positive regulation of protein polymerization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
relationship: positively_regulates GO:0045107 ! intermediate filament polymerization

[Term]
id: GO:0030842
name: regulation of intermediate filament depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the disassembly of intermediate filaments by the removal of monomers from a filament." [GOC:mah]
is_a: GO:0043244 ! regulation of protein complex disassembly
is_a: GO:0045108 ! regulation of intermediate filament polymerization or depolymerization
relationship: regulates GO:0045106 ! intermediate filament depolymerization

[Term]
id: GO:0030843
name: negative regulation of intermediate filament depolymerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah]
comment: This term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament polymerization ; GO:0030840').
synonym: "down regulation of intermediate filament depolymerization" EXACT []
synonym: "down-regulation of intermediate filament depolymerization" EXACT []
synonym: "downregulation of intermediate filament depolymerization" EXACT []
synonym: "inhibition of intermediate filament depolymerization" NARROW []
synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" BROAD []
is_a: GO:0030842 ! regulation of intermediate filament depolymerization
is_a: GO:0043242 ! negative regulation of protein complex disassembly
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
relationship: negatively_regulates GO:0045106 ! intermediate filament depolymerization

[Term]
id: GO:0030844
name: positive regulation of intermediate filament depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah]
comment: This term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament polymerization ; GO:0030841').
synonym: "activation of intermediate filament depolymerization" NARROW []
synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" BROAD []
synonym: "stimulation of intermediate filament depolymerization" NARROW []
synonym: "up regulation of intermediate filament depolymerization" EXACT []
synonym: "up-regulation of intermediate filament depolymerization" EXACT []
synonym: "upregulation of intermediate filament depolymerization" EXACT []
is_a: GO:0030842 ! regulation of intermediate filament depolymerization
is_a: GO:0043243 ! positive regulation of protein complex disassembly
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
relationship: positively_regulates GO:0045106 ! intermediate filament depolymerization

[Term]
id: GO:0030845
name: inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway
namespace: biological_process
def: "A signaling pathway that results in preventing the activation of phospholipase C in response to a signal." [GOC:dph, GOC:mah, GOC:tb, PMID:8280098]
comment: Note that this term refers to a signaling pathway, and should not be confused with function terms such as 'phospholipase inhibitor activity ; GO:0004859'.
synonym: "phospholipase C inhibition" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010519 ! negative regulation of phospholipase activity
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
relationship: negatively_regulates GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

[Term]
id: GO:0030846
name: termination of RNA polymerase II transcription, poly(A)-coupled
namespace: biological_process
def: "The process by which transcription of polyadenylated RNA polymerase II transcripts is terminated; cleavage and polyadenylylation of the mRNA 3' end is coupled to transcription termination." [PMID:12944462]
synonym: "transcription termination from Pol II promoter, poly(A) coupled" RELATED []
synonym: "transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED []
is_a: GO:0006369 ! termination of RNA polymerase II transcription

[Term]
id: GO:0030847
name: termination of RNA polymerase II transcription, poly(A)-independent
namespace: biological_process
def: "The process by which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end." [PMID:12944462]
synonym: "transcription termination from Pol II promoter, poly(A)-independent" RELATED []
synonym: "transcription termination from Pol II promoter, RNA polymerase(A)-independent" RELATED []
is_a: GO:0006369 ! termination of RNA polymerase II transcription

[Term]
id: GO:0030848
name: threo-3-hydroxyaspartate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: threo-3-hydroxy-L-aspartate = oxaloacetate + NH3." [EC:4.3.1.16, PMID:10481099]
synonym: "3-hydroxyaspartate dehydratase activity" BROAD [GOC:mcc, PMID:10481099]
synonym: "L-threo-3-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.16]
synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)" EXACT [EC:4.3.1.16]
synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.16]
synonym: "threo-3-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.16]
xref: EC:4.3.1.16
xref: MetaCyc:4.3.1.16-RXN
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0030849
name: autosome
namespace: cellular_component
def: "Any chromosome other than a sex chromosome." [GOC:mah]
comment: Note that this term is mainly relevant in organisms that have both sex chromosomes and non-sex-determining chromosomes in an individual organism.
xref: Wikipedia:Autosome
is_a: GO:0005694 ! chromosome

[Term]
id: GO:0030850
name: prostate gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [PMID:11839751]
synonym: "prostate development" EXACT []
is_a: GO:0048608 ! reproductive structure development
is_a: GO:0048732 ! gland development
relationship: part_of GO:0001655 ! urogenital system development

[Term]
id: GO:0030851
name: granulocyte differentiation
namespace: biological_process
def: "The process by which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils." [GOC:ecd, http://life.nthu.edu.tw/~g864204/dict-search1.htm]
synonym: "granulocyte cell differentiation" EXACT []
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0030852
name: regulation of granulocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of granulocyte differentiation." [GOC:mah]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
relationship: regulates GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030853
name: negative regulation of granulocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of granulocyte differentiation." [GOC:mah]
synonym: "down regulation of granulocyte differentiation" EXACT []
synonym: "down-regulation of granulocyte differentiation" EXACT []
synonym: "downregulation of granulocyte differentiation" EXACT []
synonym: "inhibition of granulocyte differentiation" NARROW []
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0030852 ! regulation of granulocyte differentiation
relationship: negatively_regulates GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030854
name: positive regulation of granulocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation." [GOC:mah]
synonym: "activation of granulocyte differentiation" NARROW []
synonym: "stimulation of granulocyte differentiation" NARROW []
synonym: "up regulation of granulocyte differentiation" EXACT []
synonym: "up-regulation of granulocyte differentiation" EXACT []
synonym: "upregulation of granulocyte differentiation" EXACT []
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0030852 ! regulation of granulocyte differentiation
relationship: positively_regulates GO:0030851 ! granulocyte differentiation

[Term]
id: GO:0030855
name: epithelial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0060429 ! epithelium development

[Term]
id: GO:0030856
name: regulation of epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0030857
name: negative regulation of epithelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]
synonym: "down regulation of epithelial cell differentiation" EXACT []
synonym: "down-regulation of epithelial cell differentiation" EXACT []
synonym: "downregulation of epithelial cell differentiation" EXACT []
synonym: "inhibition of epithelial cell differentiation" NARROW []
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: negatively_regulates GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0030858
name: positive regulation of epithelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]
synonym: "activation of epithelial cell differentiation" NARROW []
synonym: "stimulation of epithelial cell differentiation" NARROW []
synonym: "up regulation of epithelial cell differentiation" EXACT []
synonym: "up-regulation of epithelial cell differentiation" EXACT []
synonym: "upregulation of epithelial cell differentiation" EXACT []
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045597 ! positive regulation of cell differentiation
relationship: positively_regulates GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0030859
name: polarized epithelial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:mah]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium

[Term]
id: GO:0030860
name: regulation of polarized epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0030856 ! regulation of epithelial cell differentiation
relationship: regulates GO:0030859 ! polarized epithelial cell differentiation

[Term]
id: GO:0030861
name: negative regulation of polarized epithelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah]
synonym: "down regulation of polarized epithelial cell differentiation" EXACT []
synonym: "down-regulation of polarized epithelial cell differentiation" EXACT []
synonym: "downregulation of polarized epithelial cell differentiation" EXACT []
synonym: "inhibition of polarized epithelial cell differentiation" NARROW []
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0030860 ! regulation of polarized epithelial cell differentiation
relationship: negatively_regulates GO:0030859 ! polarized epithelial cell differentiation

[Term]
id: GO:0030862
name: positive regulation of polarized epithelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of polarized epithelial cell differentiation." [GOC:mah]
synonym: "activation of polarized epithelial cell differentiation" NARROW []
synonym: "stimulation of polarized epithelial cell differentiation" NARROW []
synonym: "up regulation of polarized epithelial cell differentiation" EXACT []
synonym: "up-regulation of polarized epithelial cell differentiation" EXACT []
synonym: "upregulation of polarized epithelial cell differentiation" EXACT []
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0030860 ! regulation of polarized epithelial cell differentiation
relationship: positively_regulates GO:0030859 ! polarized epithelial cell differentiation

[Term]
id: GO:0030863
name: cortical cytoskeleton
namespace: cellular_component
def: "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah]
is_a: GO:0005856 ! cytoskeleton
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0030864
name: cortical actin cytoskeleton
namespace: cellular_component
def: "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah]
is_a: GO:0030863 ! cortical cytoskeleton
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0030865
name: cortical cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
synonym: "cortical cytoskeleton organisation" EXACT [GOC:curators]
synonym: "cortical cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0030866
name: cortical actin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]
synonym: "cortical actin cytoskeleton organisation" EXACT [GOC:curators]
synonym: "cortical actin cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0030865 ! cortical cytoskeleton organization

[Term]
id: GO:0030867
name: rough endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the rough endoplasmic reticulum." [GOC:mah]
synonym: "RER membrane" EXACT []
synonym: "rough ER membrane" EXACT []
is_a: GO:0005789 ! endoplasmic reticulum membrane
relationship: part_of GO:0005791 ! rough endoplasmic reticulum

[Term]
id: GO:0030868
name: smooth endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the smooth endoplasmic reticulum." [GOC:mah]
synonym: "SER membrane" EXACT []
synonym: "smooth ER membrane" EXACT []
xref: NIF_Subcellular:sao1596955044
is_a: GO:0005789 ! endoplasmic reticulum membrane
relationship: part_of GO:0005790 ! smooth endoplasmic reticulum

[Term]
id: GO:0030869
name: RENT complex
namespace: cellular_component
def: "A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit." [PMID:12196389]
is_a: GO:0005677 ! chromatin silencing complex
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0030870
name: Mre11 complex
namespace: cellular_component
def: "Trimeric protein complex that possesses endonuclease activity; involved in DNA repair and checkpoint signaling. In Saccharomyces the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins related to the Saccharomyces proteins." [GOC:mah, PMID:11988766]
synonym: "MRN complex" EXACT []
synonym: "MRX complex" EXACT []
synonym: "Rad50 complex" EXACT []
synonym: "RAD50-MRE11-NBN complex" EXACT [CORUM:2767]
synonym: "Rad50-Rad32-Nbs1 complex" EXACT []
synonym: "RMX complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0030874
name: nucleolar chromatin
namespace: cellular_component
def: "The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA." [GOC:mah]
is_a: GO:0044452 ! nucleolar part
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0030875
name: rDNA protrusion
namespace: cellular_component
def: "Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining." [PMID:1629244]
comment: Note that this component is characterized in Schizosaccharomyces, particularly with respect to the DAPI staining pattern.
synonym: "ribosomal DNA protrusion" EXACT []
is_a: GO:0044452 ! nucleolar part
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0030874 ! nucleolar chromatin

[Term]
id: GO:0030876
name: interleukin-20 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-20; comprises an alpha and a beta subunit." [GOC:mah]
synonym: "IL-20 receptor complex" EXACT [GOC:add]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0030877
name: beta-catenin destruction complex
namespace: cellular_component
def: "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025]
synonym: "beta-catenin degradation complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0030878
name: thyroid gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone." [GOC:dgh]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0030879
name: mammary gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages." [PMID:9576833]
synonym: "mammogenesis" NARROW [GOC:dph]
is_a: GO:0048732 ! gland development

[Term]
id: GO:0030880
name: RNA polymerase complex
namespace: cellular_component
def: "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "multisubunit RNA polymerase" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0030881
name: beta-2-microglobulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with beta-2-microglobulin." [GOC:mah]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030882
name: lipid antigen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lipid antigen." [PMID:14500461]
is_a: GO:0003823 ! antigen binding
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0030883
name: endogenous lipid antigen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an endogenous cellular lipid antigen." [PMID:14500461]
is_a: GO:0030882 ! lipid antigen binding

[Term]
id: GO:0030884
name: exogenous lipid antigen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an exogenous lipid antigen (examples include microbial lipids and glycolipids)." [PMID:14500461]
is_a: GO:0030882 ! lipid antigen binding

[Term]
id: GO:0030885
name: regulation of myeloid dendritic cell activation
namespace: biological_process
def: "Any process that modulates the frequency or rate of myeloid dendritic cell activation." [GOC:mah]
is_a: GO:0002694 ! regulation of leukocyte activation
relationship: regulates GO:0001773 ! myeloid dendritic cell activation

[Term]
id: GO:0030886
name: negative regulation of myeloid dendritic cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell activation." [GOC:mah]
synonym: "down regulation of myeloid dendritic cell activation" EXACT []
synonym: "down-regulation of myeloid dendritic cell activation" EXACT []
synonym: "downregulation of myeloid dendritic cell activation" EXACT []
synonym: "inhibition of myeloid dendritic cell activation" NARROW []
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0030885 ! regulation of myeloid dendritic cell activation
relationship: negatively_regulates GO:0001773 ! myeloid dendritic cell activation

[Term]
id: GO:0030887
name: positive regulation of myeloid dendritic cell activation
namespace: biological_process
def: "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation." [GOC:mah]
synonym: "activation of myeloid dendritic cell activation" NARROW []
synonym: "stimulation of myeloid dendritic cell activation" NARROW []
synonym: "up regulation of myeloid dendritic cell activation" EXACT []
synonym: "up-regulation of myeloid dendritic cell activation" EXACT []
synonym: "upregulation of myeloid dendritic cell activation" EXACT []
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0030885 ! regulation of myeloid dendritic cell activation
relationship: positively_regulates GO:0001773 ! myeloid dendritic cell activation

[Term]
id: GO:0030888
name: regulation of B cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of B cell proliferation." [GOC:mah]
synonym: "regulation of B lymphocyte proliferation" EXACT []
synonym: "regulation of B-cell proliferation" EXACT []
synonym: "regulation of B-lymphocyte proliferation" EXACT []
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0050864 ! regulation of B cell activation
relationship: regulates GO:0042100 ! B cell proliferation

[Term]
id: GO:0030889
name: negative regulation of B cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of B cell proliferation." [GOC:mah]
synonym: "down regulation of B cell proliferation" EXACT []
synonym: "down-regulation of B cell proliferation" EXACT []
synonym: "downregulation of B cell proliferation" EXACT []
synonym: "inhibition of B cell proliferation" NARROW []
synonym: "negative regulation of B lymphocyte proliferation" EXACT []
synonym: "negative regulation of B-cell proliferation" EXACT []
synonym: "negative regulation of B-lymphocyte proliferation" EXACT []
is_a: GO:0030888 ! regulation of B cell proliferation
is_a: GO:0050672 ! negative regulation of lymphocyte proliferation
is_a: GO:0050869 ! negative regulation of B cell activation
relationship: negatively_regulates GO:0042100 ! B cell proliferation

[Term]
id: GO:0030890
name: positive regulation of B cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of B cell proliferation." [GOC:mah]
synonym: "activation of B cell proliferation" NARROW []
synonym: "positive regulation of B lymphocyte proliferation" EXACT []
synonym: "positive regulation of B-cell proliferation" EXACT []
synonym: "positive regulation of B-lymphocyte proliferation" EXACT []
synonym: "stimulation of B cell proliferation" NARROW []
synonym: "up regulation of B cell proliferation" EXACT []
synonym: "up-regulation of B cell proliferation" EXACT []
synonym: "upregulation of B cell proliferation" EXACT []
is_a: GO:0030888 ! regulation of B cell proliferation
is_a: GO:0050671 ! positive regulation of lymphocyte proliferation
is_a: GO:0050871 ! positive regulation of B cell activation
relationship: positively_regulates GO:0042100 ! B cell proliferation

[Term]
id: GO:0030891
name: VCB complex
namespace: cellular_component
def: "A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1." [GOC:mah, PMID:11865071]
synonym: "pVHL-elongin C-elongin B complex" EXACT []
synonym: "VHL complex" EXACT []
synonym: "von Hippel-Lindau tumor suppressor complex" EXACT []
is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex

[Term]
id: GO:0030892
name: mitotic cohesin complex
namespace: cellular_component
def: "A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah, PMID:12750522]
is_a: GO:0008278 ! cohesin complex

[Term]
id: GO:0030893
name: meiotic cohesin complex
namespace: cellular_component
def: "A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex." [GOC:mah, PMID:12750522]
is_a: GO:0008278 ! cohesin complex

[Term]
id: GO:0030894
name: replisome
namespace: cellular_component
def: "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw]
subset: goslim_pir
subset: gosubset_prok
synonym: "DNA synthesome complex" RELATED [CORUM:1001]
synonym: "RC complex" RELATED [CORUM:309, PMID:12006500]
synonym: "replication-competent complex" RELATED [CORUM:309, PMID:12006500]
xref: Wikipedia:Replisome
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0005657 ! replication fork

[Term]
id: GO:0030895
name: apolipoprotein B mRNA editing enzyme complex
namespace: cellular_component
def: "Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP)." [PMID:10781591]
synonym: "apoB mRNA editing enzyme complex" EXACT []
synonym: "APOBEC" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0030896
name: checkpoint clamp complex
namespace: cellular_component
def: "Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008]
comment: Note that the following subunit names have been used: human RAD9/RAD1/HUS1; S. pombe Rad9/Rad1/Hus1; S. cerevisiae Ddc1p/Rad17p/Mec3p.
synonym: "CCC" EXACT []
synonym: "Rad9-Hus1-Rad1 (9-1-1) clamp complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0030897
name: HOPS complex
namespace: cellular_component
def: "A multimeric protein complex that associates with the vacuolar membrane and is involved in homotypic vacuole fusion and vacuole protein sorting. For example, the Saccharomyces complex contains Vps41p, Vam6p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:10944212]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0030898
name: actin-dependent ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, requiring the presence of an actin filament to accelerate release of ADP and phosphate." [GOC:mah]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "actin-activated ATPase activity" EXACT []
is_a: GO:0042623 ! ATPase activity, coupled

[Term]
id: GO:0030899
name: calcium-dependent ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, requiring the presence of calcium ion (Ca2+)." [GOC:mah]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
is_a: GO:0042623 ! ATPase activity, coupled

[Term]
id: GO:0030900
name: forebrain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=forebrain]
synonym: "prosencephalon development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0030901
name: midbrain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=midbrain]
synonym: "mesencephalon development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0030902
name: hindbrain development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=hindbrain]
synonym: "rhombencephalon development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0030903
name: notochord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:dgh]
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:0030904
name: retromer complex
namespace: cellular_component
def: "A conserved multimeric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. For example, the budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p." [PMID:9700157]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0030905
name: retromer complex, outer shell
namespace: cellular_component
def: "One of two subcomplexes that combine to form the retromer, believed to be peripherally associated with the membrane. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer." [PMID:9700157]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0030904 ! retromer complex

[Term]
id: GO:0030906
name: retromer complex, inner shell
namespace: cellular_component
def: "One of two subcomplexes that combine to form the retromer, believed to be closely associated with the membrane. In budding yeast the complex comprises Vps35p, Vps29p, and Vps26p." [PMID:9700157]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0030904 ! retromer complex

[Term]
id: GO:0030907
name: MBF transcription complex
namespace: cellular_component
def: "A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi4p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p." [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:9343385]
synonym: "DSC1 transcription factor complex" EXACT []
synonym: "MBF" EXACT []
synonym: "Mlu1-box binding factor" EXACT []
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0030908
name: protein splicing
namespace: biological_process
def: "The post-translational removal of peptide sequences from within a protein sequence." [GOC:mah]
subset: gosubset_prok
xref: Wikipedia:Protein_splicing
is_a: GO:0016485 ! protein processing

[Term]
id: GO:0030909
name: non-intein-mediated protein splicing
namespace: biological_process
def: "The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030908 ! protein splicing

[Term]
id: GO:0030910
name: olfactory placode formation
namespace: biological_process
def: "The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:dgh]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0043584 ! nose development
relationship: part_of GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0030911
name: TPR domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0030912
name: response to deep water
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle." [GOC:mah]
comment: Note that this term should not be confused with 'response to flooding ; GO:0009413'; which refers to immersion in water on a shorter time scale.
is_a: GO:0009415 ! response to water

[Term]
id: GO:0030913
name: paranodal junction assembly
namespace: biological_process
def: "Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier." [PMID:14715942]
synonym: "paranodal junction biosynthesis" EXACT []
synonym: "paranodal junction formation" EXACT []
is_a: GO:0007043 ! cell-cell junction assembly
relationship: part_of GO:0032288 ! myelin assembly

[Term]
id: GO:0030914
name: STAGA complex
namespace: cellular_component
def: "A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs." [PMID:11564863]
comment: See also the cellular component term 'SAGA complex ; GO:0000124'.
synonym: "STAGA coactivator complex" EXACT []
is_a: GO:0070461 ! SAGA-type complex

[Term]
id: GO:0030915
name: Smc5-Smc6 complex
namespace: cellular_component
def: "A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739]
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0030916
name: otic vesicle formation
namespace: biological_process
def: "The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:dgh]
synonym: "otocyst biosynthesis" EXACT []
synonym: "otocyst formation" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0071600 ! otic vesicle morphogenesis

[Term]
id: GO:0030917
name: midbrain-hindbrain boundary development
namespace: biological_process
def: "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages." [GOC:dgh]
synonym: "isthmic organizer development" EXACT []
synonym: "isthmomesencephalic boundary development" EXACT []
synonym: "isthmus development" EXACT []
synonym: "MHB development" EXACT []
synonym: "midbrain-hindbrain orgainizer development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007417 ! central nervous system development
relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning

[Term]
id: GO:0030919
name: peptidyl-serine O-acetylation
namespace: biological_process
def: "The acetylation of peptidyl-serine to form peptidyl-O-acetyl-L-serine." [PMID:489587, PMID:7309355, RESID:AA0364]
subset: gosubset_prok
xref: RESID:AA0364
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0030920 ! peptidyl-serine acetylation

[Term]
id: GO:0030920
name: peptidyl-serine acetylation
namespace: biological_process
def: "The acetylation of peptidyl-serine." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006473 ! protein amino acid acetylation

[Term]
id: GO:0030921
name: peptidyl-tyrosine dehydrogenation to form (Z)-2,3-didehydrotyrosine
namespace: biological_process
def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(Z)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:9631087, RESID:AA0183]
subset: gosubset_prok
xref: RESID:AA0183
is_a: GO:0018251 ! peptidyl-tyrosine dehydrogenation

[Term]
id: GO:0030922
name: peptidyl-tyrosine dehydrogenation to form (E)-2,3-didehydrotyrosine
namespace: biological_process
def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(E)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:12623015, RESID:AA0365]
subset: gosubset_prok
xref: RESID:AA0365
is_a: GO:0018251 ! peptidyl-tyrosine dehydrogenation

[Term]
id: GO:0030923
name: metal incorporation into metallo-oxygen cluster
namespace: biological_process
def: "The formation of a cluster of several metal atoms, including manganese or calcium, with one or more bridging (mu-bond) oxygen atoms; amino acids residues in proteins that may ligate the metal oxygen cluster are histidine, aspartate, and glutamate." [GOC:jsg]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0030924
name: manganese incorporation into metallo-oxygen cluster
namespace: biological_process
def: "The incorporation of manganese into a metallo-oxygen cluster." [GOC:jsg]
subset: gosubset_prok
is_a: GO:0030923 ! metal incorporation into metallo-oxygen cluster

[Term]
id: GO:0030925
name: calcium incorporation into metallo-oxygen cluster
namespace: biological_process
def: "The incorporation of calcium into a metallo-oxygen cluster." [GOC:jsg]
subset: gosubset_prok
is_a: GO:0030923 ! metal incorporation into metallo-oxygen cluster

[Term]
id: GO:0030926
name: calcium incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide
namespace: biological_process
def: "The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366]
subset: gosubset_prok
xref: RESID:AA0366
is_a: GO:0030925 ! calcium incorporation into metallo-oxygen cluster

[Term]
id: GO:0030927
name: manganese incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide
namespace: biological_process
def: "The incorporation of manganese into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366]
subset: gosubset_prok
xref: RESID:AA0366
is_a: GO:0030924 ! manganese incorporation into metallo-oxygen cluster

[Term]
id: GO:0030929
name: ADPG pyrophosphorylase complex
namespace: cellular_component
def: "Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits." [GOC:tb, PMID:9680965]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0030930
name: homotetrameric ADPG pyrophosphorylase complex
namespace: cellular_component
def: "A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
is_a: GO:0030929 ! ADPG pyrophosphorylase complex

[Term]
id: GO:0030931
name: heterotetrameric ADPG pyrophosphorylase complex
namespace: cellular_component
def: "A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity. An example of this process is found in Mus musculus." [GOC:mah, GOC:mtg_sensu]
is_a: GO:0030929 ! ADPG pyrophosphorylase complex

[Term]
id: GO:0030932
name: amyloplast ADPG pyrophosphorylase complex
namespace: cellular_component
def: "An ADPG pyrophosphorylase complex found in the amyloplast." [GOC:mah]
is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex
relationship: part_of GO:0009501 ! amyloplast

[Term]
id: GO:0030933
name: chloroplast ADPG pyrophosphorylase complex
namespace: cellular_component
def: "An ADPG pyrophosphorylase complex found in the chloroplast." [GOC:mah]
is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex
is_a: GO:0044434 ! chloroplast part

[Term]
id: GO:0030934
name: anchoring collagen
namespace: cellular_component
def: "Any collagen polymer which links one collagen assembly, such as a collagen fibril or sheet, to other structures." [ISBN:0721639976]
synonym: "connecting collagen" EXACT [ISBN:0721639976]
synonym: "linking collagen" EXACT [ISBN:0721639976]
is_a: GO:0005581 ! collagen

[Term]
id: GO:0030935
name: sheet-forming collagen
namespace: cellular_component
def: "Any collagen polymer in which collagen triple helices associate to form sheet-like networks." [ISBN:0721639976]
synonym: "network-forming collagen" EXACT [ISBN:0815316194]
is_a: GO:0005581 ! collagen

[Term]
id: GO:0030936
name: transmembrane collagen
namespace: cellular_component
def: "Any collagen polymer that passes through a lipid bilayer membrane." [ISBN:0721639976]
synonym: "MACIT" EXACT [ISBN:0198599587]
is_a: GO:0005581 ! collagen

[Term]
id: GO:0030937
name: collagen type XVII
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices associate with hemidesmosomes and the basal lamina." [ISBN:0721639976]
is_a: GO:0030936 ! transmembrane collagen

[Term]
id: GO:0030938
name: collagen type XVIII
namespace: cellular_component
def: "A collagen homotrimer of alpha1(XVIII) chains." [ISBN:0721639976]
is_a: GO:0030934 ! anchoring collagen

[Term]
id: GO:0030939
name: response to long-day photoperiod
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the light phase being longer than the dark." [GOC:pj]
comment: This term was made obsolete because it was wrongly defined.
is_obsolete: true
consider: GO:0048571

[Term]
id: GO:0030940
name: response to short-day photoperiod
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the dark phase being longer than the light." [GOC:pj]
comment: This term was made obsolete because it was wrongly defined.
is_obsolete: true
consider: GO:0048572

[Term]
id: GO:0030941
name: chloroplast targeting sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast." [GOC:mah]
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0030942
name: endoplasmic reticulum signal peptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum." [GOC:mah]
synonym: "ER signal peptide binding" EXACT []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0030943
name: mitochondrion targeting sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion." [GOC:mah]
synonym: "mitochondrial targeting sequence binding" EXACT []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0030944
name: DDEL sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:mah]
is_a: GO:0046923 ! ER retention sequence binding

[Term]
id: GO:0030945
name: protein tyrosine phosphatase activity, via thiol-phosphate intermediate
namespace: molecular_function
def: "The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate." [GOC:hjd]
is_a: GO:0004725 ! protein tyrosine phosphatase activity

[Term]
id: GO:0030946
name: protein tyrosine phosphatase activity, metal-dependent
namespace: molecular_function
def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate, by a mechanism that requires metal ions." [GOC:mah]
is_a: GO:0004725 ! protein tyrosine phosphatase activity

[Term]
id: GO:0030947
name: regulation of vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh]
synonym: "regulation of vascular endothelial growth factor receptor signalling pathway" EXACT []
synonym: "regulation of VEGF receptor signaling pathway" EXACT []
synonym: "regulation of VEGF receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway

[Term]
id: GO:0030948
name: negative regulation of vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh]
synonym: "down regulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
synonym: "down-regulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
synonym: "downregulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
synonym: "inhibition of vascular endothelial growth factor receptor signaling pathway" NARROW []
synonym: "negative regulation of vascular endothelial growth factor receptor signalling pathway" EXACT []
synonym: "negative regulation of VEGF receptor signaling pathway" EXACT []
synonym: "negative regulation of VEGF receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0030947 ! regulation of vascular endothelial growth factor receptor signaling pathway
relationship: negatively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway

[Term]
id: GO:0030949
name: positive regulation of vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh]
synonym: "activation of vascular endothelial growth factor receptor signaling pathway" NARROW []
synonym: "positive regulation of vascular endothelial growth factor receptor signalling pathway" EXACT []
synonym: "positive regulation of VEGF receptor signaling pathway" EXACT []
synonym: "positive regulation of VEGF receptor signalling pathway" EXACT []
synonym: "stimulation of vascular endothelial growth factor receptor signaling pathway" NARROW []
synonym: "up regulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
synonym: "up-regulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
synonym: "upregulation of vascular endothelial growth factor receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0030947 ! regulation of vascular endothelial growth factor receptor signaling pathway
relationship: positively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway

[Term]
id: GO:0030950
name: establishment or maintenance of actin cytoskeleton polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures." [GOC:mah]
is_a: GO:0030036 ! actin cytoskeleton organization
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity

[Term]
id: GO:0030951
name: establishment or maintenance of microtubule cytoskeleton polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity

[Term]
id: GO:0030952
name: establishment or maintenance of cytoskeleton polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures." [GOC:mah]
is_a: GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0030953
name: spindle astral microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles." [GOC:mah]
synonym: "astral microtubule organisation" EXACT [GOC:curators]
synonym: "astral microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007051 ! spindle organization
is_a: GO:0031122 ! cytoplasmic microtubule organization

[Term]
id: GO:0030954
name: spindle astral microtubule nucleation
namespace: biological_process
def: "The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule." [GOC:mah]
is_a: GO:0007020 ! microtubule nucleation
is_a: GO:0030953 ! spindle astral microtubule organization

[Term]
id: GO:0030955
name: potassium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah]
subset: gosubset_prok
is_a: GO:0031420 ! alkali metal ion binding

[Term]
id: GO:0030956
name: glutamyl-tRNA(Gln) amidotransferase complex
namespace: cellular_component
def: "A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ; GO:0050567'.
synonym: "AdT" RELATED [GOC:rb]
synonym: "GatCAB" NARROW [GOC:rb]
synonym: "GatFAB" NARROW [GOC:rb]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0030957
name: Tat protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus." [GOC:mah, PMID:9094689]
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0030958
name: RITS complex
namespace: cellular_component
def: "A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing." [PMID:14704433]
is_a: GO:0031332 ! RNAi effector complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0005720 ! nuclear heterochromatin

[Term]
id: GO:0030959
name: peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine
namespace: biological_process
def: "The posttranslation modification of two peptidyl-tyrosines to form a 3'-(3'-L-tyrosinyl)-L-tyrosine protein cross-link." [RESID:AA0367]
subset: gosubset_prok
xref: RESID:AA0367
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0030960
name: peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine
namespace: biological_process
def: "The posttranslation modification of two peptidyl-tyrosines to form a 3'-(O4'-L-tyrosinyl)-L-tyrosine protein cross-link." [PDB:1NGK, PMID:12719529, RESID:AA0368]
subset: gosubset_prok
xref: RESID:AA0368
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0030961
name: peptidyl-arginine hydroxylation
namespace: biological_process
def: "The hydroxylation of peptidyl-arginine to form peptidyl-hydroxyarginine." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0030962
name: peptidyl-arginine dihydroxylation to peptidyl-3,4-dihydroxy-L-arginine
namespace: biological_process
def: "The dihydroxylation of peptidyl-arginine to form peptidyl-3,4-dihydroxy-L-arginine." [PMID:10978343, RESID:AA0369]
subset: gosubset_prok
xref: RESID:AA0369
is_a: GO:0030961 ! peptidyl-arginine hydroxylation

[Term]
id: GO:0030963
name: peptidyl-lysine dihydroxylation to 4,5-dihydroxy-L-lysine
namespace: biological_process
def: "The dihydroxylation of peptidyl-lysine to peptidyl-4,5-dihydroxy-L-lysine." [PMID:10978343, RESID:AA0370]
subset: gosubset_prok
xref: RESID:AA0370
is_a: GO:0017185 ! peptidyl-lysine hydroxylation

[Term]
id: GO:0030964
name: NADH dehydrogenase complex
namespace: cellular_component
alt_id: GO:0030025
alt_id: GO:0030966
alt_id: GO:0031675
alt_id: GO:0031677
alt_id: GO:0031678
alt_id: GO:0045280
def: "An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone." [GOC:mah]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (quinone) activity ; GO:0050136'.
subset: goslim_pir
subset: gosubset_prok
synonym: "Complex I" EXACT []
synonym: "NADH dehydrogenase complex (plastoquinone)" NARROW []
synonym: "NADH dehydrogenase complex (quinone)" NARROW []
synonym: "NADH dehydrogenase complex (ubiquinone)" NARROW []
synonym: "NADH:plastoquinone reductase complex" NARROW []
synonym: "plastid NADH dehydrogenase complex (plastoquinone)" NARROW []
xref: Wikipedia:NADH_dehydrogenase
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0030965
name: plasma membrane electron transport, NADH to quinone
namespace: biological_process
def: "The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation and results in the generation of a proton gradient, mediated by the enzyme known as NADH-quinone oxidoreductase." [GOC:mah, GOC:sd]
subset: gosubset_prok
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0042774 ! plasma membrane ATP synthesis coupled electron transport

[Term]
id: GO:0030967
name: ER-nuclear sterol response pathway
namespace: biological_process
def: "The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of sterol depletion, and resulting in the activation of transcription by SREBP." [GOC:mah, PMID:12923525]
synonym: "endoplasmic reticulum to nucleus sterol response pathway" EXACT []
synonym: "endoplasmic reticulum-nuclear sterol response pathway" EXACT []
synonym: "ER to nucleus sterol response pathway" EXACT []
is_a: GO:0032933 ! SREBP-mediated signaling pathway
is_a: GO:0071501 ! cellular response to sterol depletion

[Term]
id: GO:0030968
name: endoplasmic reticulum unfolded protein response
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]
comment: Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any cellular response to the presence of unfolded proteins anywhere in the cell. Also see 'ER-associated protein catabolic process ; GO:0030433'.
synonym: "ER unfolded protein response" EXACT []
synonym: "erUPR" EXACT []
synonym: "SREBP-mediated signalling pathway" RELATED []
is_a: GO:0006984 ! ER-nuclear signaling pathway
is_a: GO:0034620 ! cellular response to unfolded protein
is_a: GO:0034976 ! response to endoplasmic reticulum stress

[Term]
id: GO:0030969
name: UFP-specific transcription factor mRNA processing during unfolded protein response
namespace: biological_process
def: "The spliceosome-independent cleavage and ligation of the mRNA encoding a UFP-specific transcription factor to remove a single intron, thereby increasing both the translational efficiency of the processed mRNA and the activity of the protein it encodes." [GOC:mah, PMID:12042763]
synonym: "unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor" RELATED []
synonym: "unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase" RELATED []
is_a: GO:0006397 ! mRNA processing
relationship: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response

[Term]
id: GO:0030970
name: retrograde protein transport, ER to cytosol
namespace: biological_process
def: "The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon." [PMID:11994744]
synonym: "retrograde protein transport, endoplasmic reticulum to cytosol" EXACT []
is_a: GO:0006886 ! intracellular protein transport

[Term]
id: GO:0030971
name: receptor tyrosine kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity." [GOC:mah]
synonym: "transmembrane receptor protein tyrosine kinase ligand binding" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0030972
name: cleavage of cytosolic proteins during apoptosis
namespace: biological_process
def: "The proteolytic degradation of proteins in the cytosol during apoptosis." [GOC:mah, ISBN:0815332181]
synonym: "apoptotic cleavage of cytosolic proteins" EXACT []
is_a: GO:0006921 ! cell structure disassembly during apoptosis

[Term]
id: GO:0030973
name: molybdate ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with molybdate (MoO4 2-) ions." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0030974
name: thiamin pyrophosphate transport
namespace: biological_process
def: "The directed movement of thiamin pyrophosphate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mlg]
synonym: "thiamin diphosphate transport" EXACT []
synonym: "thiamine diphosphate transport" EXACT []
synonym: "thiamine pyrophosphate transport" EXACT []
synonym: "TPP transport" EXACT []
is_a: GO:0015888 ! thiamin transport
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0030975
name: thiamin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mlg]
synonym: "thiamine binding" EXACT []
synonym: "vitamin B1 binding" EXACT []
is_a: GO:0019842 ! vitamin binding

[Term]
id: GO:0030976
name: thiamin pyrophosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg, http://cancerweb.ncl.ac.uk/]
synonym: "aneurine pyrophosphate binding" EXACT []
synonym: "cocarboxylase binding" EXACT []
synonym: "diphosphothiamin binding" EXACT []
synonym: "thiamine pyrophosphate binding" EXACT []
synonym: "TPP binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0050662 ! coenzyme binding

[Term]
id: GO:0030977
name: taurine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with taurine." [GOC:mlg]
is_a: GO:0043176 ! amine binding

[Term]
id: GO:0030978
name: alpha-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah]
subset: gosubset_prok
synonym: "alpha-glucan metabolism" EXACT []
is_a: GO:0006073 ! cellular glucan metabolic process

[Term]
id: GO:0030979
name: alpha-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah]
synonym: "alpha-glucan anabolism" EXACT []
synonym: "alpha-glucan biosynthesis" EXACT []
synonym: "alpha-glucan formation" EXACT []
synonym: "alpha-glucan synthesis" EXACT []
is_a: GO:0009250 ! glucan biosynthetic process
is_a: GO:0030978 ! alpha-glucan metabolic process

[Term]
id: GO:0030980
name: alpha-glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alpha-glucans." [GOC:mah]
subset: gosubset_prok
synonym: "alpha-glucan breakdown" EXACT []
synonym: "alpha-glucan catabolism" EXACT []
synonym: "alpha-glucan degradation" EXACT []
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0030978 ! alpha-glucan metabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process

[Term]
id: GO:0030981
name: cortical microtubule cytoskeleton
namespace: cellular_component
def: "The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane." [GOC:mah]
is_a: GO:0030863 ! cortical cytoskeleton
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015630 ! microtubule cytoskeleton

[Term]
id: GO:0030982
name: adventurous gliding motility
namespace: biological_process
def: "A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime." [GOC:mlg, PMID:11967173]
subset: gosubset_prok
synonym: "adventurous gliding movement" EXACT []
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0030983
name: mismatched DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]
is_a: GO:0003690 ! double-stranded DNA binding

[Term]
id: GO:0030984
name: kininogen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a kininogen, any of a group of plasma proteins that are kinin precursors." [GOC:mah, PMID:9520414]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0030985
name: high molecular weight kininogen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a kininogen of high molecular mass." [GOC:mah, PMID:9520414]
synonym: "HK binding" EXACT []
synonym: "HMW kininogen binding" EXACT []
is_a: GO:0030984 ! kininogen binding

[Term]
id: GO:0030986
name: low molecular weight kininogen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a kininogen of low molecular mass." [GOC:mah, PMID:9520414]
synonym: "LK binding" EXACT []
synonym: "LMW kininogen binding" EXACT []
is_a: GO:0030984 ! kininogen binding

[Term]
id: GO:0030987
name: high molecular weight kininogen receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a high molecular weight kininogen receptor." [GOC:mah]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0030988
name: high molecular weight kininogen receptor complex
namespace: cellular_component
def: "A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins." [GOC:mah, PMID:11290596]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0030989
name: dynein-driven meiotic oscillatory nuclear movement
namespace: biological_process
def: "The cell cycle process whereby oscillatory movement of the nucleus during meiotic prophase I occurs. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein. It is known to play a central role in meiotic recombination and homologous chromosome pairing; as observed in S. pombe." [GOC:vw, PMID:16111942, PMID:9572142]
synonym: "HNM" EXACT []
synonym: "horsetail movement" EXACT []
synonym: "horsetail nuclear movement" EXACT [GOC:vw]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0030473 ! nuclear migration along microtubule
relationship: part_of GO:0007126 ! meiosis

[Term]
id: GO:0030990
name: intraflagellar transport particle
namespace: cellular_component
def: "A nonmembrane-bound oliogmeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:kmv, PMID:14570576]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0030991
name: intraflagellar transport particle A
namespace: cellular_component
def: "The smaller subcomplex of the intraflagellar transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:kmv, PMID:14570576]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part
relationship: part_of GO:0030990 ! intraflagellar transport particle

[Term]
id: GO:0030992
name: intraflagellar transport particle B
namespace: cellular_component
def: "The larger subcomplex of the intraflagellar transport particle; characterized complexes have molecular weights around 550 kDa." [GOC:kmv, PMID:14570576]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part
relationship: part_of GO:0030990 ! intraflagellar transport particle

[Term]
id: GO:0030993
name: axonemal heterotrimeric kinesin-II complex
namespace: cellular_component
def: "A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme." [GOC:kmv, PMID:14570576]
is_a: GO:0043234 ! protein complex
is_a: GO:0044447 ! axoneme part

[Term]
id: GO:0030994
name: primary cell septum disassembly
namespace: biological_process
def: "Dissolution of the primary septum during cell separation." [PMID:12665550]
synonym: "hydrolysis of primary cell septum" EXACT []
synonym: "primary cell septum hydrolysis" EXACT []
synonym: "primary septum hydrolysis" BROAD []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0000920 ! cell separation during cytokinesis

[Term]
id: GO:0030995
name: cell septum edging catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation." [GOC:mah, PMID:15194814]
synonym: "cell septum edging hydrolysis" EXACT []
synonym: "hydrolysis of cell septum edging" EXACT []
synonym: "hydrolysis of edging of cell septum" EXACT []
synonym: "septum edging hydrolysis" BROAD []
is_a: GO:0032506 ! cytokinetic process
is_a: GO:0044248 ! cellular catabolic process
relationship: part_of GO:0000920 ! cell separation during cytokinesis

[Term]
id: GO:0030996
name: cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def: "The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of nitrogen." [GOC:dph, GOC:tb, GOC:vw]
is_a: GO:0006995 ! cellular response to nitrogen starvation
is_a: GO:0007050 ! cell cycle arrest

[Term]
id: GO:0030997
name: regulation of centriole-centriole cohesion
namespace: biological_process
def: "Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker." [PMID:11076968]
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
relationship: part_of GO:0007098 ! centrosome cycle
relationship: regulates GO:0010457 ! centriole-centriole cohesion

[Term]
id: GO:0030998
name: linear element
namespace: cellular_component
def: "A proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase. Linear elements have a structure related to but not equivalent to the synaptonemal complex." [GOC:jb]
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000794 ! condensed nuclear chromosome

[Term]
id: GO:0030999
name: linear element assembly
namespace: biological_process
def: "The cell cycle process whereby a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase." [GOC:jb, GOC:mah]
synonym: "linear element formation" RELATED [GOC:dph]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007129 ! synapsis

[Term]
id: GO:0031000
name: response to caffeine
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [ChEBI:27732, GOC:ef, GOC:mah]
is_a: GO:0014074 ! response to purine
is_a: GO:0043279 ! response to alkaloid

[Term]
id: GO:0031001
name: response to brefeldin A
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus." [GOC:mah]
is_a: GO:0046677 ! response to antibiotic

[Term]
id: GO:0031002
name: actin rod
namespace: cellular_component
def: "A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Found in the germinating spores of Dictyostelium discoideum." [GOC:kp]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0031003
name: actin tubule
namespace: cellular_component
def: "A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together." [GOC:kp]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0031002 ! actin rod

[Term]
id: GO:0031004
name: potassium ion-transporting ATPase complex
namespace: cellular_component
def: "Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex." [PMID:10608856, PMID:9858692, TIGR_TIGRFAMS:TIGR01497]
synonym: "Kdp system complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0031005
name: filamin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain." [GOC:mah, PMID:11336782]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0031006
name: filamin-A binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with filamin-A." [GOC:mah, PMID:11336782]
synonym: "ABP-280 binding" NARROW []
synonym: "alpha-filamin binding" NARROW []
synonym: "filamin A binding" EXACT []
synonym: "filamin-1 binding" NARROW []
is_a: GO:0031005 ! filamin binding

[Term]
id: GO:0031007
name: filamin-B binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with filamin-B." [GOC:mah, PMID:11336782]
synonym: "ABP-278/276 binding" NARROW []
synonym: "beta-filamin binding" NARROW []
synonym: "filamin B binding" EXACT []
synonym: "filamin-3 binding" NARROW []
is_a: GO:0031005 ! filamin binding

[Term]
id: GO:0031008
name: filamin-C binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with filamin-C, a filamin isoform that contains an 81 amino acid insertion in repeat 20, not present in filamin-A or -B." [GOC:mah, PMID:11336782]
synonym: "ABPL binding" NARROW []
synonym: "filamin C binding" EXACT []
synonym: "filamin-2 binding" NARROW []
synonym: "gamma-filamin binding" NARROW []
is_a: GO:0031005 ! filamin binding

[Term]
id: GO:0031009
name: plastid ADPG pyrophosphorylase complex
namespace: cellular_component
def: "An ADPG pyrophosphorylase complex found in a plastid." [GOC:mah]
is_a: GO:0030931 ! heterotetrameric ADPG pyrophosphorylase complex
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0031010
name: ISWI complex
namespace: cellular_component
def: "Any chromatin remodeling complex that contains an ATPase subunit of the ISWI family." [GOC:mah, PMID:15020051]
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0031011
name: Ino80 complex
namespace: cellular_component
def: "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh]
synonym: "INO80 chromatin remodeling complex" EXACT []
is_a: GO:0016585 ! chromatin remodeling complex
is_a: GO:0033202 ! DNA helicase complex
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0031012
name: extracellular matrix
namespace: cellular_component
def: "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants)." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Extracellular_matrix
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0031013
name: troponin I binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with troponin I, the inhibitory subunit of the troponin complex." [GOC:mah, ISBN:0815316194]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0031014
name: troponin T binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0031015
name: karyopherin docking complex
namespace: cellular_component
def: "A subcomplex of the nuclear pore complex that interacts with karyopherin-cargo complexes; a well-characterized example in Saccharomyces contains Asm4p, Nup53p, and Nup170p." [PMID:11867631, PMID:9864357]
synonym: "Asm4p-containing complex" NARROW []
synonym: "nuclear pore subcomplex" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:0031016
name: pancreas development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes." [GOC:cvs]
xref: Wikipedia:Pancreas
is_a: GO:0048513 ! organ development

[Term]
id: GO:0031017
name: exocrine pancreas development
namespace: biological_process
def: "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells." [GOC:cvs]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0031016 ! pancreas development
relationship: part_of GO:0035272 ! exocrine system development

[Term]
id: GO:0031018
name: endocrine pancreas development
namespace: biological_process
def: "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin." [GOC:cvs]
xref: Reactome:186712 "Regulation of beta-cell development"
xref: Reactome:210744 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"
xref: Reactome:210745 "Regulation of gene expression in beta cells"
xref: Reactome:210746 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"
xref: Reactome:210747 "Regulation of gene expression in early pancreatic precursor cells"
xref: Reactome:210774 "Regulation of Beta-Cell Development"
xref: Reactome:449116 "Regulation of gene expression in beta cells"
xref: Reactome:449117 "Regulation of beta-cell development"
xref: Reactome:449139 "Regulation of gene expression in early pancreatic precursor cells"
xref: Reactome:449140 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"
xref: Reactome:449204 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"
xref: Reactome:470251 "Regulation of gene expression in beta cells"
xref: Reactome:470252 "Regulation of beta-cell development"
xref: Reactome:470253 "Regulation of gene expression in early pancreatic precursor cells"
xref: Reactome:470254 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"
xref: Reactome:470325 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"
xref: Reactome:487911 "Regulation of gene expression in beta cells"
xref: Reactome:487912 "Regulation of beta-cell development"
xref: Reactome:487932 "Regulation of gene expression in early pancreatic precursor cells"
xref: Reactome:487933 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"
xref: Reactome:488002 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"
xref: Reactome:507881 "Regulation of gene expression in beta cells"
xref: Reactome:507882 "Regulation of beta-cell development"
xref: Reactome:507903 "Regulation of gene expression in early pancreatic precursor cells"
xref: Reactome:507904 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"
xref: Reactome:507965 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"
xref: Reactome:517791 "Regulation of gene expression in beta cells"
xref: Reactome:517792 "Regulation of beta-cell development"
xref: Reactome:517793 "Regulation of gene expression in early pancreatic precursor cells"
xref: Reactome:517837 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"
xref: Reactome:517887 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"
xref: Reactome:526622 "Regulation of gene expression in beta cells"
xref: Reactome:526623 "Regulation of beta-cell development"
xref: Reactome:526624 "Regulation of gene expression in early pancreatic precursor cells"
xref: Reactome:526673 "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"
xref: Reactome:526710 "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"
xref: Reactome:531422 "Regulation of gene expression in beta cells"
xref: Reactome:531423 "Regulation of beta-cell development"
xref: Reactome:536792 "Regulation of gene expression in beta cells"
xref: Reactome:536793 "Regulation of beta-cell development"
xref: Reactome:542550 "Regulation of gene expression in beta cells"
xref: Reactome:542551 "Regulation of beta-cell development"
xref: Reactome:547876 "Regulation of gene expression in beta cells"
xref: Reactome:547877 "Regulation of beta-cell development"
xref: Reactome:552453 "Regulation of gene expression in beta cells"
xref: Reactome:552454 "Regulation of beta-cell development"
xref: Reactome:558062 "Regulation of gene expression in beta cells"
xref: Reactome:558063 "Regulation of beta-cell development"
xref: Reactome:568708 "Regulation of gene expression in beta cells"
xref: Reactome:568709 "Regulation of beta-cell development"
xref: Reactome:581911 "Regulation of gene expression in beta cells"
xref: Reactome:581912 "Regulation of beta-cell development"
xref: Reactome:585949 "Regulation of gene expression in beta cells"
xref: Reactome:585950 "Regulation of beta-cell development"
xref: Reactome:592805 "Regulation of gene expression in beta cells"
xref: Reactome:592806 "Regulation of beta-cell development"
xref: Reactome:595532 "Regulation of gene expression in beta cells"
xref: Reactome:595533 "Regulation of beta-cell development"
xref: Reactome:597417 "Regulation of gene expression in beta cells"
xref: Reactome:597418 "Regulation of beta-cell development"
xref: Reactome:598186 "Regulation of gene expression in beta cells"
xref: Reactome:598187 "Regulation of beta-cell development"
xref: Reactome:599758 "Regulation of gene expression in beta cells"
xref: Reactome:599759 "Regulation of beta-cell development"
xref: Reactome:600659 "Regulation of gene expression in beta cells"
xref: Reactome:600660 "Regulation of beta-cell development"
xref: Reactome:602568 "Regulation of gene expression in beta cells"
xref: Reactome:602569 "Regulation of beta-cell development"
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0031016 ! pancreas development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0031019
name: mitochondrial mRNA editing complex
namespace: cellular_component
def: "An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates." [GOC:mah, PMID:12139607]
synonym: "mitochondrial editosome" EXACT []
is_a: GO:0045293 ! mRNA editing complex

[Term]
id: GO:0031020
name: plastid mRNA editing complex
namespace: cellular_component
def: "An mRNA editing complex found in a plastid." [GOC:mah]
synonym: "plastid editosome" EXACT []
is_a: GO:0045293 ! mRNA editing complex

[Term]
id: GO:0031021
name: interphase microtubule organizing center
namespace: cellular_component
def: "A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus." [PMID:15068790]
synonym: "iMTOC" EXACT []
synonym: "interphase microtubule organising center" EXACT []
synonym: "interphase MTOC" EXACT []
is_a: GO:0005815 ! microtubule organizing center

[Term]
id: GO:0031022
name: nuclear migration along microfilament
namespace: biological_process
def: "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins." [GOC:mah]
synonym: "nuclear migration, microfilament-mediated" EXACT []
is_a: GO:0007097 ! nuclear migration
is_a: GO:0030048 ! actin filament-based movement

[Term]
id: GO:0031023
name: microtubule organizing center organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "microtubule organising center organisation" EXACT [GOC:curators]
synonym: "microtubule organizing center organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization
relationship: part_of GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0031024
name: interphase microtubule organizing center assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center." [GOC:mah, PMID:15068790]
synonym: "interphase microtubule organising center biosynthesis" EXACT []
synonym: "interphase microtubule organising center formation" EXACT []
synonym: "interphase microtubule organizing center biogenesis" RELATED [GOC:mah]
synonym: "interphase microtubule organizing centre assembly" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0031023 ! microtubule organizing center organization

[Term]
id: GO:0031025
name: equatorial microtubule organizing center disassembly
namespace: biological_process
def: "The process by which the equatorial microtubule organizing center is disassembled at the end of mitosis." [GOC:mah, PMID:15068790]
synonym: "equatorial microtubule organising center disassembly" EXACT []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0031121 ! equatorial microtubule organization

[Term]
id: GO:0031026
name: glutamate synthase complex
namespace: cellular_component
def: "A complex that possesses glutamate synthase activity." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031027
name: glutamate synthase complex (NADH)
namespace: cellular_component
def: "A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525]
is_a: GO:0031026 ! glutamate synthase complex

[Term]
id: GO:0031028
name: septation initiation signaling
namespace: biological_process
def: "The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis." [GOC:mah, GOC:vw, PMID:16775007]
synonym: "septation initiation network" EXACT []
synonym: "septation initiation signalling" EXACT []
synonym: "SIN" EXACT []
is_a: GO:0007096 ! regulation of exit from mitosis
is_a: GO:0007265 ! Ras protein signal transduction
is_a: GO:0031991 ! regulation of contractile ring contraction involved in cytokinesis during cell cycle
relationship: part_of GO:0000917 ! barrier septum formation

[Term]
id: GO:0031029
name: regulation of septation initiation signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of septation initiation signaling." [GOC:mah]
synonym: "regulation of septation initiation network" EXACT []
synonym: "regulation of septation initiation signalling" EXACT []
is_a: GO:0032955 ! regulation of barrier septum formation
is_a: GO:0046578 ! regulation of Ras protein signal transduction
relationship: regulates GO:0031028 ! septation initiation signaling

[Term]
id: GO:0031030
name: negative regulation of septation initiation signaling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of septation initiation signaling." [GOC:mah]
synonym: "down regulation of septation initiation signaling" EXACT []
synonym: "down-regulation of septation initiation signaling" EXACT []
synonym: "downregulation of septation initiation signaling" EXACT []
synonym: "inhibition of septation initiation signaling" NARROW []
synonym: "negative regulation of septation initiation network" EXACT []
synonym: "negative regulation of septation initiation signalling" EXACT []
is_a: GO:0010974 ! negative regulation of barrier septum formation
is_a: GO:0031029 ! regulation of septation initiation signaling
is_a: GO:0046580 ! negative regulation of Ras protein signal transduction
relationship: negatively_regulates GO:0031028 ! septation initiation signaling

[Term]
id: GO:0031031
name: positive regulation of septation initiation signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of septation initiation signaling." [GOC:mah]
synonym: "activation of septation initiation signaling" NARROW []
synonym: "positive regulation of septation initiation network" EXACT []
synonym: "positive regulation of septation initiation signalling" EXACT []
synonym: "stimulation of septation initiation signaling" NARROW []
synonym: "up regulation of septation initiation signaling" EXACT []
synonym: "up-regulation of septation initiation signaling" EXACT []
synonym: "upregulation of septation initiation signaling" EXACT []
is_a: GO:0010973 ! positive regulation of barrier septum formation
is_a: GO:0031029 ! regulation of septation initiation signaling
is_a: GO:0046579 ! positive regulation of Ras protein signal transduction
relationship: positively_regulates GO:0031028 ! septation initiation signaling

[Term]
id: GO:0031032
name: actomyosin structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]
comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins.
synonym: "actomyosin organization" EXACT []
synonym: "actomyosin structure organisation" EXACT [GOC:curators]
synonym: "actomyosin structure organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030036 ! actin cytoskeleton organization

[Term]
id: GO:0031033
name: myosin filament assembly or disassembly
namespace: biological_process
def: "The formation or disassembly of a filament composed of myosin molecules." [GOC:mah]
comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins; myosin structures are sufficiently closely associated with actin filaments to be included with the actin cytoskeleton.
synonym: "myosin polymerization or depolymerization" RELATED []
is_a: GO:0030036 ! actin cytoskeleton organization

[Term]
id: GO:0031034
name: myosin filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a filament composed of myosin molecules." [GOC:mah]
synonym: "myosin polymerization" RELATED []
is_a: GO:0031033 ! myosin filament assembly or disassembly
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0031035
name: myosin filament disassembly
namespace: biological_process
def: "The disassembly of a filament composed of myosin molecules." [GOC:mah]
synonym: "myosin depolymerization" RELATED []
is_a: GO:0031033 ! myosin filament assembly or disassembly
is_a: GO:0043624 ! cellular protein complex disassembly

[Term]
id: GO:0031036
name: myosin II filament assembly
namespace: biological_process
def: "The formation of a bipolar filament composed of myosin II molecules." [GOC:mah]
synonym: "myosin II polymerization" RELATED []
is_a: GO:0031034 ! myosin filament assembly
is_a: GO:0031038 ! myosin II filament assembly or disassembly

[Term]
id: GO:0031037
name: myosin II filament disassembly
namespace: biological_process
def: "The disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah]
synonym: "myosin II depolymerization" RELATED []
is_a: GO:0031035 ! myosin filament disassembly
is_a: GO:0031038 ! myosin II filament assembly or disassembly

[Term]
id: GO:0031038
name: myosin II filament assembly or disassembly
namespace: biological_process
def: "The formation or disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah]
synonym: "myosin II polymerization or depolymerization" RELATED []
is_a: GO:0031033 ! myosin filament assembly or disassembly

[Term]
id: GO:0031039
name: macronucleus
namespace: cellular_component
def: "A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell." [GOC:ns]
xref: Wikipedia:Macronucleus
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0031040
name: micronucleus
namespace: cellular_component
def: "A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell." [GOC:ns]
xref: Wikipedia:Micronucleus
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0031041
name: O-glycan processing, core 5
namespace: biological_process
def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 5 O-glycan structure, GalNAc-alpha-1->3-GalNAc." [GOC:mah, PMID:10580130]
subset: gosubset_prok
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0031042
name: O-glycan processing, core 6
namespace: biological_process
def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 6 O-glycan structure, GlcNAc-beta-1->6-GalNAc." [GOC:mah, PMID:10580130]
subset: gosubset_prok
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0031043
name: O-glycan processing, core 7
namespace: biological_process
def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-1->6-GalNAc." [GOC:mah, PMID:10580130]
subset: gosubset_prok
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0031044
name: O-glycan processing, core 8
namespace: biological_process
def: "The stepwise addition of sugar residues to the initially added O-linked sugar (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-1->3-GalNAc." [GOC:mah, PMID:10580130]
subset: gosubset_prok
is_a: GO:0016266 ! O-glycan processing

[Term]
id: GO:0031045
name: dense core granule
namespace: cellular_component
def: "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [PMID:14690495]
synonym: "dense core vesicle" EXACT [GOC:kmv]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0031046
name: spindle pole body duplication in cytoplasm
namespace: biological_process
def: "Construction of a new spindle pole body adjacent to the existing spindle pole body exterior to the outer nuclear envelope." [GOC:clt]
is_a: GO:0030474 ! spindle pole body duplication

[Term]
id: GO:0031047
name: gene silencing by RNA
namespace: biological_process
def: "Any process by which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054]
synonym: "RNA-mediated gene silencing" EXACT [GOC:dph, GOC:tb]
is_a: GO:0016458 ! gene silencing

[Term]
id: GO:0031048
name: chromatin silencing by small RNA
namespace: biological_process
def: "Repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:mtg_lung, GOC:ns]
synonym: "RNA interference-like chromatin silencing" EXACT []
synonym: "RNA-mediated chromatin silencing" EXACT [GOC:dph, GOC:tb]
synonym: "RNA-mediated TGS" BROAD []
synonym: "RNA-mediated transcriptional silencing" EXACT []
synonym: "RNAi-like chromatin silencing" EXACT []
synonym: "small RNA-mediated heterochromatic silencing" EXACT []
is_a: GO:0006342 ! chromatin silencing
is_a: GO:0031047 ! gene silencing by RNA

[Term]
id: GO:0031049
name: programmed DNA elimination
namespace: biological_process
def: "The DNA metabolic process by which micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the developing macronucleus (anlage) of a ciliate." [GOC:mah, GOC:ns]
subset: goslim_pir
is_a: GO:0006259 ! DNA metabolic process

[Term]
id: GO:0031050
name: dsRNA fragmentation
namespace: biological_process
def: "Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function." [GOC:ns]
synonym: "double-stranded RNA fragmentation" EXACT []
is_a: GO:0006396 ! RNA processing
is_a: GO:0071359 ! cellular response to dsRNA

[Term]
id: GO:0031051
name: scnRNA production
namespace: biological_process
def: "Cleavage of noncoding, double-stranded RNAs transcribed from the micronuclear genome to produce scnRNAs, small RNAs (~28 nucleotides) that direct the deletion of micronuclear-limited sequences from the developing macronuclear genome." [PMID:15196465]
is_a: GO:0031050 ! dsRNA fragmentation
relationship: part_of GO:0031049 ! programmed DNA elimination

[Term]
id: GO:0031052
name: chromosome breakage
namespace: biological_process
def: "Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage." [GOC:ns]
comment: Note that this term refers to breakage of chromosomes during normal DNA rearrangements characteristic of ciliates; it is not to be used for DNA damage or other abnormal occurrences.
synonym: "establishment or maintenance of heterochromatin architecture" EXACT [GOC:mah]
is_a: GO:0051276 ! chromosome organization
relationship: part_of GO:0031049 ! programmed DNA elimination

[Term]
id: GO:0031053
name: primary microRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [PMID:15211354]
synonym: "pri-miRNA processing" EXACT []
synonym: "primary miRNA processing" EXACT []
is_a: GO:0034470 ! ncRNA processing
relationship: part_of GO:0035196 ! production of miRNAs involved in gene silencing by miRNA

[Term]
id: GO:0031054
name: pre-microRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [PMID:15211354]
synonym: "pre-miRNA processing" EXACT []
is_a: GO:0034470 ! ncRNA processing
relationship: part_of GO:0035196 ! production of miRNAs involved in gene silencing by miRNA

[Term]
id: GO:0031055
name: chromatin remodeling at centromere
namespace: biological_process
def: "Dynamic structural changes in centromeric DNA." [GOC:mah]
is_a: GO:0006338 ! chromatin remodeling

[Term]
id: GO:0031056
name: regulation of histone modification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0033044 ! regulation of chromosome organization
relationship: regulates GO:0016570 ! histone modification

[Term]
id: GO:0031057
name: negative regulation of histone modification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]
synonym: "down regulation of histone modification" EXACT []
synonym: "down-regulation of histone modification" EXACT []
synonym: "downregulation of histone modification" EXACT []
synonym: "inhibition of histone modification" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0031056 ! regulation of histone modification
is_a: GO:0031400 ! negative regulation of protein modification process
relationship: negatively_regulates GO:0016570 ! histone modification

[Term]
id: GO:0031058
name: positive regulation of histone modification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]
synonym: "activation of histone modification" NARROW []
synonym: "stimulation of histone modification" NARROW []
synonym: "up regulation of histone modification" EXACT []
synonym: "up-regulation of histone modification" EXACT []
synonym: "upregulation of histone modification" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0031056 ! regulation of histone modification
is_a: GO:0031401 ! positive regulation of protein modification process
relationship: positively_regulates GO:0016570 ! histone modification

[Term]
id: GO:0031059
name: histone deacetylation at centromere
namespace: biological_process
def: "The removal of acetyl groups from histones in centromeric DNA." [GOC:mah]
is_a: GO:0016575 ! histone deacetylation

[Term]
id: GO:0031060
name: regulation of histone methylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]
is_a: GO:0031056 ! regulation of histone modification
relationship: regulates GO:0016571 ! histone methylation

[Term]
id: GO:0031061
name: negative regulation of histone methylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]
synonym: "down regulation of histone methylation" EXACT []
synonym: "down-regulation of histone methylation" EXACT []
synonym: "downregulation of histone methylation" EXACT []
synonym: "inhibition of histone methylation" NARROW []
is_a: GO:0031057 ! negative regulation of histone modification
is_a: GO:0031060 ! regulation of histone methylation
relationship: negatively_regulates GO:0016571 ! histone methylation

[Term]
id: GO:0031062
name: positive regulation of histone methylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]
synonym: "activation of histone methylation" NARROW []
synonym: "stimulation of histone methylation" NARROW []
synonym: "up regulation of histone methylation" EXACT []
synonym: "up-regulation of histone methylation" EXACT []
synonym: "upregulation of histone methylation" EXACT []
is_a: GO:0031058 ! positive regulation of histone modification
is_a: GO:0031060 ! regulation of histone methylation
relationship: positively_regulates GO:0016571 ! histone methylation

[Term]
id: GO:0031063
name: regulation of histone deacetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah]
is_a: GO:0031056 ! regulation of histone modification
relationship: regulates GO:0016575 ! histone deacetylation
relationship: regulates GO:0070846 ! Hsp90 deacetylation

[Term]
id: GO:0031064
name: negative regulation of histone deacetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah]
synonym: "down regulation of histone deacetylation" EXACT []
synonym: "down-regulation of histone deacetylation" EXACT []
synonym: "downregulation of histone deacetylation" EXACT []
synonym: "inhibition of histone deacetylation" NARROW []
is_a: GO:0031057 ! negative regulation of histone modification
is_a: GO:0031063 ! regulation of histone deacetylation
relationship: negatively_regulates GO:0016575 ! histone deacetylation
relationship: negatively_regulates GO:0070846 ! Hsp90 deacetylation

[Term]
id: GO:0031065
name: positive regulation of histone deacetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah]
synonym: "activation of histone deacetylation" NARROW []
synonym: "stimulation of histone deacetylation" NARROW []
synonym: "up regulation of histone deacetylation" EXACT []
synonym: "up-regulation of histone deacetylation" EXACT []
synonym: "upregulation of histone deacetylation" EXACT []
is_a: GO:0031058 ! positive regulation of histone modification
is_a: GO:0031063 ! regulation of histone deacetylation
relationship: positively_regulates GO:0016575 ! histone deacetylation
relationship: positively_regulates GO:0070846 ! Hsp90 deacetylation

[Term]
id: GO:0031066
name: regulation of histone deacetylation at centromere
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah]
is_a: GO:0031063 ! regulation of histone deacetylation
relationship: regulates GO:0031059 ! histone deacetylation at centromere

[Term]
id: GO:0031067
name: negative regulation of histone deacetylation at centromere
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the removal of acetyl groups to histones in centromeric DNA." [GOC:mah]
synonym: "down regulation of histone deacetylation at centromere" EXACT []
synonym: "down-regulation of histone deacetylation at centromere" EXACT []
synonym: "downregulation of histone deacetylation at centromere" EXACT []
synonym: "inhibition of histone deacetylation at centromere" NARROW []
is_a: GO:0031064 ! negative regulation of histone deacetylation
is_a: GO:0031066 ! regulation of histone deacetylation at centromere
relationship: negatively_regulates GO:0031059 ! histone deacetylation at centromere

[Term]
id: GO:0031068
name: positive regulation of histone deacetylation at centromere
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah]
synonym: "activation of histone deacetylation at centromere" NARROW []
synonym: "stimulation of histone deacetylation at centromere" NARROW []
synonym: "up regulation of histone deacetylation at centromere" EXACT []
synonym: "up-regulation of histone deacetylation at centromere" EXACT []
synonym: "upregulation of histone deacetylation at centromere" EXACT []
is_a: GO:0031065 ! positive regulation of histone deacetylation
is_a: GO:0031066 ! regulation of histone deacetylation at centromere
relationship: positively_regulates GO:0031059 ! histone deacetylation at centromere

[Term]
id: GO:0031069
name: hair follicle morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the hair follicle are generated and organized." [GOC:ln]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0022405 ! hair cycle process
relationship: part_of GO:0001942 ! hair follicle development
relationship: part_of GO:0048730 ! epidermis morphogenesis

[Term]
id: GO:0031070
name: intronic snoRNA processing
namespace: biological_process
def: "The biogenesis of a snoRNA molecule which resides within, and is processed from, the intron of a pre-mRNA." [GOC:vw]
is_a: GO:0043144 ! snoRNA processing

[Term]
id: GO:0031071
name: cysteine desulfurase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7]
subset: gosubset_prok
synonym: "cysteine desulfurylase activity" EXACT [EC:2.8.1.7]
synonym: "IscS" RELATED [EC:2.8.1.7]
synonym: "L-cysteine:enzyme cysteine sulfurtransferase activity" EXACT [EC:2.8.1.7]
synonym: "NIFS" RELATED [EC:2.8.1.7]
synonym: "NifS" RELATED [EC:2.8.1.7]
synonym: "SufS" RELATED [EC:2.8.1.7]
xref: EC:2.8.1.7
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0031072
name: heat shock protein binding
namespace: molecular_function
def: "Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031073
name: cholesterol 26-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol." [GOC:mah, PMID:950499]
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0031074
name: nucleocytoplasmic shuttling complex
namespace: cellular_component
def: "Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores." [GOC:mah]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031076
name: embryonic camera-type eye development
namespace: biological_process
def: "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu]
synonym: "embryonic eye development" EXACT []
is_a: GO:0043010 ! camera-type eye development
relationship: part_of GO:0009790 ! embryonic development

[Term]
id: GO:0031077
name: post-embryonic camera-type eye development
namespace: biological_process
def: "The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu]
synonym: "post-embryonic camera-style eye development" EXACT []
is_a: GO:0043010 ! camera-type eye development
relationship: part_of GO:0009791 ! post-embryonic development

[Term]
id: GO:0031078
name: histone deacetylase activity (H3-K14 specific)
namespace: molecular_function
def: "Catalysis of the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [GOC:mah, PMID:11884604]
is_a: GO:0004407 ! histone deacetylase activity

[Term]
id: GO:0031079
name: picornain 3C activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly." [EC:3.4.22.28]
comment: This term was made obsolete because it represents a gene product.
synonym: "3C protease activity" EXACT [EC:3.4.22.28]
synonym: "3C proteinase activity" EXACT [EC:3.4.22.28]
synonym: "coxsackievirus 3C proteinase activity" EXACT [EC:3.4.22.28]
synonym: "cysteine proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "foot-and-mouth protease 3C activity" NARROW [EC:3.4.22.28]
synonym: "foot-and-mouth-disease virus proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "hepatitis A virus 3C proteinase activity" EXACT [EC:3.4.22.28]
synonym: "picornavirus endopeptidase 3C activity" NARROW [EC:3.4.22.28]
synonym: "poliovirus protease 3C activity" NARROW [EC:3.4.22.28]
synonym: "poliovirus proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "protease 3C" RELATED [EC:3.4.22.28]
synonym: "rhinovirus protease 3C activity" NARROW [EC:3.4.22.28]
synonym: "rhinovirus proteinase 3C" RELATED [EC:3.4.22.28]
synonym: "tomato ringspot nepovirus 3C-related protease" RELATED [EC:3.4.22.28]
xref: EC:3.4.22.28
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0031080
name: Nup107-160 complex
namespace: cellular_component
def: "A subcomplex of the nuclear pore complex (NPC) involved in mRNA export and NPC assembly. Contains conserved nucleoporins and other proteins; for example, the Saccharomyces complex contains Nup84p, Nup85p, Nup120p, Nup145p-C, Seh1p, Sec13p, and Nup133p." [PMID:10747086, PMID:11823431, PMID:15226438]
synonym: "Nup107-120 complex" EXACT []
synonym: "Nup84 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:0031081
name: nuclear pore distribution
namespace: biological_process
def: "Any process that establishes the spatial arrangement of nuclear pores within the nuclear envelope." [GOC:mah]
synonym: "positioning of nuclear pores" RELATED []
is_a: GO:0006997 ! nucleus organization
is_a: GO:0051664 ! nuclear pore localization

[Term]
id: GO:0031082
name: BLOC complex
namespace: cellular_component
def: "Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex." [PMID:15102850, PMID:15261680]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0031083
name: BLOC-1 complex
namespace: cellular_component
def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850]
is_a: GO:0031082 ! BLOC complex

[Term]
id: GO:0031084
name: BLOC-2 complex
namespace: cellular_component
def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru." [PMID:12548288, PMID:14718540, PMID:15031569]
is_a: GO:0031082 ! BLOC complex

[Term]
id: GO:0031085
name: BLOC-3 complex
namespace: cellular_component
def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins." [PMID:12756248]
is_a: GO:0031082 ! BLOC complex

[Term]
id: GO:0031086
name: nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
namespace: biological_process
def: "A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability." [GOC:krc, PMID:15225542, PMID:15225544]
synonym: "deadenylation-independent mRNA decay" EXACT []
synonym: "deadenylylation-independent mRNA decay" EXACT []
synonym: "mRNA breakdown, deadenylation-independent decay" EXACT []
synonym: "mRNA catabolic process, deadenylation-independent" EXACT []
synonym: "mRNA catabolic process, deadenylylation-independent" EXACT []
synonym: "mRNA catabolism, deadenylation-independent" EXACT []
synonym: "mRNA catabolism, deadenylation-independent decay" EXACT []
synonym: "mRNA catabolism, deadenylylation-independent" EXACT []
synonym: "mRNA degradation, deadenylation-independent decay" EXACT []
synonym: "nuclear mRNA catabolic process, deadenylation-independent decay" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0031087
name: deadenylation-independent decapping of nuclear-transcribed mRNA
namespace: biological_process
def: "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544]
synonym: "deadenylation-independent decapping of nuclear mRNA" RELATED []
synonym: "deadenylylation-independent decapping" EXACT []
is_a: GO:0031086 ! nuclear-transcribed mRNA catabolic process, deadenylation-independent decay

[Term]
id: GO:0031088
name: platelet dense granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the platelet dense granule." [GOC:mah]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042827 ! platelet dense granule

[Term]
id: GO:0031089
name: platelet dense granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the platelet dense granule." [GOC:mah]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0042827 ! platelet dense granule

[Term]
id: GO:0031090
name: organelle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an organelle." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016020 ! membrane
is_a: GO:0044422 ! organelle part
relationship: part_of GO:0043227 ! membrane-bounded organelle

[Term]
id: GO:0031091
name: platelet alpha granule
namespace: cellular_component
def: "A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG)." [PMID:8467233]
synonym: "platelet alpha-granule" EXACT []
xref: Wikipedia:Platelet_alpha-granule
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0031092
name: platelet alpha granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the platelet alpha granule." [GOC:mah, PMID:8467233]
synonym: "platelet alpha-granule membrane" EXACT []
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0031091 ! platelet alpha granule

[Term]
id: GO:0031093
name: platelet alpha granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the platelet alpha granule." [GOC:mah, PMID:8467233]
synonym: "platelet alpha-granule lumen" EXACT []
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0031091 ! platelet alpha granule

[Term]
id: GO:0031094
name: platelet dense tubular network
namespace: cellular_component
def: "A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin." [PMID:1322202]
subset: goslim_pir
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0031095
name: platelet dense tubular network membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the platelet dense tubular network." [GOC:mah, PMID:1322202]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0031094 ! platelet dense tubular network

[Term]
id: GO:0031096
name: platelet dense tubular network lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the platelet dense tubular network." [GOC:mah, PMID:1322202]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0031094 ! platelet dense tubular network

[Term]
id: GO:0031097
name: medial cortex
namespace: cellular_component
def: "A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation." [GOC:vw, PMID:15572668, PMID:19474789]
synonym: "medial ring" EXACT [GOC:vw]
is_a: GO:0032155 ! cell division site part
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0031098
name: stress-activated protein kinase signaling pathway
namespace: biological_process
def: "A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals." [GOC:mah]
synonym: "JNK signaling pathway" NARROW []
synonym: "JNK signalling pathway" NARROW []
synonym: "SAPK signaling pathway" EXACT []
synonym: "SAPK signalling pathway" EXACT []
synonym: "stress-activated protein kinase signalling pathway" EXACT []
is_a: GO:0007242 ! intracellular signaling cascade
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0031099
name: regeneration
namespace: biological_process
def: "The regrowth of a lost or destroyed body part, such as an organ or tissue." [GOC:mah]
xref: Wikipedia:Regeneration_(biology)
is_a: GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0031100
name: organ regeneration
namespace: biological_process
def: "The regrowth of a lost or destroyed organ." [GOC:mah]
is_a: GO:0009887 ! organ morphogenesis
is_a: GO:0031099 ! regeneration

[Term]
id: GO:0031101
name: fin regeneration
namespace: biological_process
def: "The regrowth of fin tissue following its loss or destruction." [GOC:dgh]
is_a: GO:0033334 ! fin morphogenesis
is_a: GO:0042246 ! tissue regeneration

[Term]
id: GO:0031102
name: neuron projection regeneration
namespace: biological_process
def: "The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb]
synonym: "neurite regeneration" NARROW [GOC:mah]
is_a: GO:0031099 ! regeneration
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0048812 ! neuron projection morphogenesis

[Term]
id: GO:0031103
name: axon regeneration
namespace: biological_process
def: "The regrowth of axons following their loss or damage." [GOC:dgh, GOC:dph, GOC:tb]
is_a: GO:0007409 ! axonogenesis
is_a: GO:0031102 ! neuron projection regeneration
is_a: GO:0048678 ! response to axon injury

[Term]
id: GO:0031104
name: dendrite regeneration
namespace: biological_process
def: "The regrowth of dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb]
is_a: GO:0031102 ! neuron projection regeneration
is_a: GO:0048813 ! dendrite morphogenesis

[Term]
id: GO:0031105
name: septin complex
namespace: cellular_component
def: "Any of several heterooligomeric complexes containing multiple septins." [GOC:mah, PMID:15385632]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0032156 ! septin cytoskeleton

[Term]
id: GO:0031106
name: septin ring organization
namespace: biological_process
def: "Control of the formation, spatial distribution, and breakdown of the septin ring." [GOC:mah]
subset: gosubset_prok
synonym: "septin ring organisation" EXACT [GOC:curators]
is_a: GO:0032185 ! septin cytoskeleton organization

[Term]
id: GO:0031107
name: septin ring disassembly
namespace: biological_process
def: "The controlled breakdown of a septin ring." [GOC:mah]
is_a: GO:0022411 ! cellular component disassembly
relationship: part_of GO:0031106 ! septin ring organization

[Term]
id: GO:0031108
name: holo-[acyl-carrier-protein] biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of holo-[acyl-carrier protein]." [GOC:mlg]
synonym: "holo-[acyl-carrier protein] biosynthesis" EXACT []
synonym: "holo-[acyl-carrier-protein] anabolism" EXACT []
synonym: "holo-[acyl-carrier-protein] biosynthesis" EXACT []
synonym: "holo-[acyl-carrier-protein] formation" EXACT []
synonym: "holo-[acyl-carrier-protein] synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0031109
name: microtubule polymerization or depolymerization
namespace: biological_process
def: "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0031110
name: regulation of microtubule polymerization or depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah]
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
relationship: regulates GO:0031109 ! microtubule polymerization or depolymerization

[Term]
id: GO:0031111
name: negative regulation of microtubule polymerization or depolymerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah]
synonym: "down regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "down-regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "downregulation of microtubule polymerization or depolymerization" EXACT []
synonym: "inhibition of microtubule polymerization or depolymerization" NARROW []
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
relationship: negatively_regulates GO:0031109 ! microtubule polymerization or depolymerization

[Term]
id: GO:0031112
name: positive regulation of microtubule polymerization or depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah]
synonym: "activation of microtubule polymerization or depolymerization" NARROW []
synonym: "stimulation of microtubule polymerization or depolymerization" NARROW []
synonym: "up regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "up-regulation of microtubule polymerization or depolymerization" EXACT []
synonym: "upregulation of microtubule polymerization or depolymerization" EXACT []
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
relationship: positively_regulates GO:0031109 ! microtubule polymerization or depolymerization

[Term]
id: GO:0031113
name: regulation of microtubule polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule polymerization." [GOC:mah]
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:0032271 ! regulation of protein polymerization
relationship: regulates GO:0046785 ! microtubule polymerization

[Term]
id: GO:0031114
name: regulation of microtubule depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah]
synonym: "regulation of microtubule disassembly" EXACT []
is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization
is_a: GO:0043244 ! regulation of protein complex disassembly
relationship: regulates GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0031115
name: negative regulation of microtubule polymerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule polymerization." [GOC:mah]
synonym: "down regulation of microtubule polymerization" EXACT []
synonym: "down-regulation of microtubule polymerization" EXACT []
synonym: "downregulation of microtubule polymerization" EXACT []
synonym: "inhibition of microtubule polymerization" NARROW []
is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization
is_a: GO:0031113 ! regulation of microtubule polymerization
is_a: GO:0032272 ! negative regulation of protein polymerization
relationship: negatively_regulates GO:0046785 ! microtubule polymerization

[Term]
id: GO:0031116
name: positive regulation of microtubule polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah]
synonym: "activation of microtubule polymerization" NARROW []
synonym: "stimulation of microtubule polymerization" NARROW []
synonym: "up regulation of microtubule polymerization" EXACT []
synonym: "up-regulation of microtubule polymerization" EXACT []
synonym: "upregulation of microtubule polymerization" EXACT []
is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization
is_a: GO:0031113 ! regulation of microtubule polymerization
is_a: GO:0032273 ! positive regulation of protein polymerization
relationship: positively_regulates GO:0046785 ! microtubule polymerization

[Term]
id: GO:0031117
name: positive regulation of microtubule depolymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization." [GOC:mah]
synonym: "activation of microtubule depolymerization" NARROW []
synonym: "microtubule destabilization" EXACT []
synonym: "positive regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb]
synonym: "positive regulation of microtubule disassembly" EXACT []
synonym: "stimulation of microtubule depolymerization" NARROW []
synonym: "up regulation of microtubule depolymerization" EXACT []
synonym: "up-regulation of microtubule depolymerization" EXACT []
synonym: "upregulation of microtubule depolymerization" EXACT []
is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization
is_a: GO:0031114 ! regulation of microtubule depolymerization
is_a: GO:0043243 ! positive regulation of protein complex disassembly
relationship: positively_regulates GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0031118
name: rRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule." [GOC:mah]
is_a: GO:0000154 ! rRNA modification
is_a: GO:0001522 ! pseudouridine synthesis

[Term]
id: GO:0031119
name: tRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in a tRNA molecule." [GOC:mah]
is_a: GO:0001522 ! pseudouridine synthesis
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0031120
name: snRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in an snRNA molecule." [GOC:mah]
is_a: GO:0001522 ! pseudouridine synthesis
is_a: GO:0040031 ! snRNA modification

[Term]
id: GO:0031121
name: equatorial microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins at the midpoint of a cell." [GOC:mah, GOC:vw]
synonym: "equatorial microtubule organisation" EXACT [GOC:curators]
synonym: "equatorial microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0031122
name: cytoplasmic microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah]
synonym: "cytoplasmic microtubule organisation" EXACT [GOC:curators]
synonym: "cytoplasmic microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0031123
name: RNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah]
subset: gosubset_prok
synonym: "RNA 3' end processing" EXACT []
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0031124
name: mRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]
subset: gosubset_prok
synonym: "mRNA 3' end processing" EXACT []
xref: Reactome:448974 "mRNA 3'-end processing"
xref: Reactome:470314 "mRNA 3'-end processing"
xref: Reactome:487784 "mRNA 3'-end processing"
xref: Reactome:507748 "mRNA 3'-end processing"
xref: Reactome:517679 "mRNA 3'-end processing"
xref: Reactome:526512 "mRNA 3'-end processing"
xref: Reactome:568583 "mRNA 3'-end processing"
xref: Reactome:581789 "mRNA 3'-end processing"
xref: Reactome:72187 "mRNA 3'-end processing"
is_a: GO:0006397 ! mRNA processing
is_a: GO:0031123 ! RNA 3'-end processing

[Term]
id: GO:0031125
name: rRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an rRNA molecule." [GOC:mah]
synonym: "rRNA 3' end processing" EXACT []
is_a: GO:0006364 ! rRNA processing
is_a: GO:0043628 ! ncRNA 3'-end processing

[Term]
id: GO:0031126
name: snoRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a snoRNA molecule." [GOC:mah]
synonym: "snoRNA 3' end processing" EXACT []
is_a: GO:0043144 ! snoRNA processing
is_a: GO:0043628 ! ncRNA 3'-end processing

[Term]
id: GO:0031127
name: alpha(1,2)-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,2)-linkage." [GOC:mah]
subset: gosubset_prok
is_a: GO:0008417 ! fucosyltransferase activity

[Term]
id: GO:0031128
name: developmental induction
namespace: biological_process
def: "Signaling at short range between cells or tissues of different ancestry and developmental potential that results in one cell or tissue effecting a developmental change in the other." [GOC:mah]
is_a: GO:0045168 ! cell-cell signaling involved in cell fate specification

[Term]
id: GO:0031129
name: inductive cell-cell signaling
namespace: biological_process
def: "Signaling at short range between cells of different ancestry and developmental potential that results in one cell or group of cells effecting a developmental change in the other. This is often done by secretion of proteins by one cell which affects the neighboring cells and causes them to adopt a certain fate." [GOC:mah]
synonym: "inductive cell-cell signalling" EXACT []
is_a: GO:0031128 ! developmental induction

[Term]
id: GO:0031130
name: creation of an inductive signal
namespace: biological_process
def: "The process by which one cell or group of cells sends a signal over a short range to another cell or group of cells of different ancestry and developmental potential, thereby effecting a developmental change in the latter." [GOC:mah]
is_a: GO:0003001 ! generation of a signal involved in cell-cell signaling
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0031129 ! inductive cell-cell signaling

[Term]
id: GO:0031131
name: reception of an inductive signal
namespace: biological_process
def: "The process by which one cell or group of cells receives, transduces, and responds to a signal generated by another cell or group of cells of different ancestry and developmental potential, such that the recipient cell(s) undergo a developmental change." [GOC:mah]
is_a: GO:0031668 ! cellular response to extracellular stimulus
relationship: part_of GO:0031129 ! inductive cell-cell signaling

[Term]
id: GO:0031132
name: serine 3-dehydrogenase activity
namespace: molecular_function
def: "L-serine + NADP+ = 2-ammoniomalonate semialdehyde + NADPH + H+." [EC:1.1.1.276]
synonym: "L-serine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.276]
xref: EC:1.1.1.276
xref: Wikipedia:Serine_3-dehydrogenase
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0031133
name: regulation of axon diameter
namespace: biological_process
def: "Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained." [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0032536 ! regulation of cell projection size
is_a: GO:0050770 ! regulation of axonogenesis

[Term]
id: GO:0031134
name: sister chromatid biorientation
namespace: biological_process
def: "The cell cycle process whereby sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles." [PMID:15309047]
synonym: "chromosome biorientation" EXACT []
synonym: "sister kinetochore biorientation" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051313 ! attachment of spindle microtubules to chromosome
relationship: part_of GO:0007080 ! mitotic metaphase plate congression

[Term]
id: GO:0031135
name: negative regulation of conjugation
namespace: biological_process
def: "Any process that decreases the rate of conjugation." [GOC:mah]
synonym: "down regulation of conjugation" EXACT []
synonym: "down-regulation of conjugation" EXACT []
synonym: "downregulation of conjugation" EXACT []
synonym: "inhibition of conjugation" NARROW []
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0046999 ! regulation of conjugation
relationship: negatively_regulates GO:0000746 ! conjugation

[Term]
id: GO:0031136
name: positive regulation of conjugation
namespace: biological_process
def: "Any process that increases the rate or frequency of conjugation." [GOC:mah]
synonym: "activation of conjugation" NARROW []
synonym: "stimulation of conjugation" NARROW []
synonym: "up regulation of conjugation" EXACT []
synonym: "up-regulation of conjugation" EXACT []
synonym: "upregulation of conjugation" EXACT []
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0046999 ! regulation of conjugation
relationship: positively_regulates GO:0000746 ! conjugation

[Term]
id: GO:0031137
name: regulation of conjugation with cellular fusion
namespace: biological_process
def: "Any process that modulates the rate or frequency of conjugation with cellular fusion." [GOC:mah]
is_a: GO:0046999 ! regulation of conjugation
relationship: regulates GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0031138
name: negative regulation of conjugation with cellular fusion
namespace: biological_process
def: "Any process that decreases the rate or frequency of conjugation with cellular fusion." [GOC:mah]
synonym: "down regulation of conjugation with cellular fusion" EXACT []
synonym: "down-regulation of conjugation with cellular fusion" EXACT []
synonym: "downregulation of conjugation with cellular fusion" EXACT []
synonym: "inhibition of conjugation with cellular fusion" NARROW []
is_a: GO:0031135 ! negative regulation of conjugation
is_a: GO:0031137 ! regulation of conjugation with cellular fusion
relationship: negatively_regulates GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0031139
name: positive regulation of conjugation with cellular fusion
namespace: biological_process
def: "Any process that increases the rate or frequency of conjugation with cellular fusion." [GOC:mah]
synonym: "activation of conjugation with cellular fusion" NARROW []
synonym: "stimulation of conjugation with cellular fusion" NARROW []
synonym: "up regulation of conjugation with cellular fusion" EXACT []
synonym: "up-regulation of conjugation with cellular fusion" EXACT []
synonym: "upregulation of conjugation with cellular fusion" EXACT []
is_a: GO:0031136 ! positive regulation of conjugation
is_a: GO:0031137 ! regulation of conjugation with cellular fusion
relationship: positively_regulates GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0031140
name: induction of conjugation upon nutrient starvation
namespace: biological_process
def: "The process by which a cell initiates conjugation with cellular fusion upon starvation for one or more nutrients." [GOC:mah]
is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion

[Term]
id: GO:0031141
name: induction of conjugation upon carbon starvation
namespace: biological_process
def: "The process by which a cell initiates conjugation with cellular fusion upon carbon starvation." [GOC:mah]
is_a: GO:0031140 ! induction of conjugation upon nutrient starvation

[Term]
id: GO:0031142
name: induction of conjugation upon nitrogen starvation
namespace: biological_process
def: "The process by which a cell initiates conjugation with cellular fusion upon nitrogen starvation." [GOC:mah]
is_a: GO:0006995 ! cellular response to nitrogen starvation
is_a: GO:0031140 ! induction of conjugation upon nutrient starvation

[Term]
id: GO:0031143
name: pseudopodium
namespace: cellular_component
def: "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
synonym: "pseudopod" EXACT []
xref: Wikipedia:Pseudopod
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0031144
name: proteasome localization
namespace: biological_process
def: "Any process by which the proteasome is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "establishment and maintenance of proteasome localization" EXACT []
is_a: GO:0034629 ! cellular protein complex localization

[Term]
id: GO:0031145
name: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [PMID:15380083]
synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT []
synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT []
synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation" EXACT []
synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT []
xref: Reactome:174048 "APC/C:Cdc20 mediated degradation of Cyclin B"
xref: Reactome:174143 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:174154 "APC/C:Cdc20 mediated degradation of Securin"
xref: Reactome:174178 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
xref: Reactome:174184 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
xref: Reactome:448681 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:448829 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
xref: Reactome:448836 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
xref: Reactome:448838 "APC/C:Cdc20 mediated degradation of Cyclin B"
xref: Reactome:448863 "APC/C:Cdc20 mediated degradation of Securin"
xref: Reactome:469804 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:469945 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
xref: Reactome:469952 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
xref: Reactome:469954 "APC/C:Cdc20 mediated degradation of Cyclin B"
xref: Reactome:469980 "APC/C:Cdc20 mediated degradation of Securin"
xref: Reactome:487503 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:487653 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
xref: Reactome:487660 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
xref: Reactome:487662 "APC/C:Cdc20 mediated degradation of Cyclin B"
xref: Reactome:487685 "APC/C:Cdc20 mediated degradation of Securin"
xref: Reactome:507458 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:507610 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
xref: Reactome:507613 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
xref: Reactome:507615 "APC/C:Cdc20 mediated degradation of Cyclin B"
xref: Reactome:507638 "APC/C:Cdc20 mediated degradation of Securin"
xref: Reactome:517570 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:517571 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
xref: Reactome:517576 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
xref: Reactome:517578 "APC/C:Cdc20 mediated degradation of Cyclin B"
xref: Reactome:517714 "APC/C:Cdc20 mediated degradation of Securin"
xref: Reactome:526558 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:531350 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:536726 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:536904 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
xref: Reactome:542466 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:547608 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:547690 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
xref: Reactome:547691 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
xref: Reactome:547693 "APC/C:Cdc20 mediated degradation of Cyclin B"
xref: Reactome:547800 "APC/C:Cdc20 mediated degradation of Securin"
xref: Reactome:552275 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:552276 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
xref: Reactome:552277 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
xref: Reactome:552279 "APC/C:Cdc20 mediated degradation of Cyclin B"
xref: Reactome:552364 "APC/C:Cdc20 mediated degradation of Securin"
xref: Reactome:557898 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
xref: Reactome:557975 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:558167 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
xref: Reactome:568419 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:568497 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
xref: Reactome:568498 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
xref: Reactome:568501 "APC/C:Cdc20 mediated degradation of Cyclin B"
xref: Reactome:568618 "APC/C:Cdc20 mediated degradation of Securin"
xref: Reactome:581621 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:581708 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
xref: Reactome:581709 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
xref: Reactome:581712 "APC/C:Cdc20 mediated degradation of Cyclin B"
xref: Reactome:581822 "APC/C:Cdc20 mediated degradation of Securin"
xref: Reactome:586010 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:592518 "APC/C-mediated degradation of cell cycle proteins"
xref: Reactome:592616 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
xref: Reactome:592617 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
xref: Reactome:592619 "APC/C:Cdc20 mediated degradation of Cyclin B"
xref: Reactome:592728 "APC/C:Cdc20 mediated degradation of Securin"
is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process

[Term]
id: GO:0031146
name: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083]
synonym: "SCF-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT []
synonym: "SCF-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT []
synonym: "SCF-dependent proteasomal ubiquitin-dependent protein degradation" EXACT []
is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process

[Term]
id: GO:0031147
name: 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells." [GOC:mah, PMID:10706822]
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolism" EXACT []
synonym: "DIF-1 metabolic process" EXACT []
synonym: "DIF-1 metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process

[Term]
id: GO:0031148
name: DIF-1 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells." [GOC:mah, PMID:10706822]
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one anabolism" EXACT []
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthesis" EXACT []
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthetic process" EXACT []
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one formation" EXACT []
synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one synthesis" EXACT []
synonym: "DIF-1 biosynthesis" EXACT []
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0031147 ! 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process

[Term]
id: GO:0031149
name: sorocarp stalk cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a sorocarp stalk cell, any of the cellulose-covered cells that form the stalk of a sorocarp. An example of this process is found in Dictyostelium discoideum." [DDB_REF:5048 "DictyBase paper repository", GOC:mah, GOC:mtg_sensu, ISBN:0521583640]
synonym: "stalk cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0031150 ! sorocarp stalk development

[Term]
id: GO:0031150
name: sorocarp stalk development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum." [DDB_REF:5048 "DictyBase paper repository", GOC:mtg_sensu, ISBN:0521583640]
synonym: "sorophore development" EXACT []
synonym: "stalk development" BROAD []
synonym: "stalk formation" BROAD []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0031154 ! culmination during sorocarp development

[Term]
id: GO:0031151
name: histone methyltransferase activity (H3-K79 specific)
namespace: molecular_function
def: "Catalysis of the addition of a methyl group onto lysine at position 79 of the histone H3 protein." [GOC:mah, PMID:15371351]
synonym: "histone lysine N-methyltransferase activity (H3-K79 specific)" EXACT []
synonym: "histone methylase activity (H3-K79 specific)" EXACT [GOC:mah]
is_a: GO:0018024 ! histone-lysine N-methyltransferase activity

[Term]
id: GO:0031152
name: aggregation involved in sorocarp development
namespace: biological_process
def: "The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640]
synonym: "aggregate development involved in sorocarp development" EXACT []
synonym: "aggregation during fruiting body development" EXACT []
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030587 ! sorocarp development

[Term]
id: GO:0031153
name: slug development during sorocarp development
namespace: biological_process
def: "The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development begins when the aggregate rises upwards to form a finger-shaped structure and ends when culmination begins. Slug development takes place during sorocarp development." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640]
synonym: "migratory slug development during sorocarp development" NARROW []
synonym: "pseudoplasmodium biosynthesis" EXACT []
synonym: "pseudoplasmodium formation" EXACT []
synonym: "slug development during fruiting body development" EXACT []
synonym: "standing slug development during sorocarp development" NARROW []
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030587 ! sorocarp development

[Term]
id: GO:0031154
name: culmination during sorocarp development
namespace: biological_process
def: "The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Clumination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640]
synonym: "culminant development" EXACT []
synonym: "culmination during fruiting body development" EXACT []
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030587 ! sorocarp development

[Term]
id: GO:0031155
name: regulation of fruiting body development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fruiting body development." [GOC:mah]
synonym: "regulation of fruiting body formation" EXACT []
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0030582 ! fruiting body development

[Term]
id: GO:0031156
name: regulation of sorocarp development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum." [DDB_REF:2530 "DictyBase paper repository", GOC:mah, GOC:mtg_sensu]
synonym: "regulation of fruiting body development" BROAD []
synonym: "regulation of fruiting body formation" BROAD []
is_a: GO:0031155 ! regulation of fruiting body development
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:0030587 ! sorocarp development

[Term]
id: GO:0031157
name: regulation of aggregate size involved in sorocarp development
namespace: biological_process
def: "Any process that modulates the size of the aggregate formed during sorocarp formation." [DDB_REF:5048 "DictyBase paper repository", GOC:mah, GOC:mtg_sensu, GOC:pg]
synonym: "regulation of aggregation during fruiting body biosynthesis" RELATED []
synonym: "regulation of aggregation during fruiting body formation" RELATED []
is_a: GO:0060176 ! regulation of aggregation involved in sorocarp development
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0031158
name: negative regulation of aggregate size involved in sorocarp development
namespace: biological_process
def: "Any process that decreases the size of the aggregate formed during sorocarp formation." [DDB_REF:5048 "DictyBase paper repository", GOC:mah, GOC:mtg_sensu, GOC:pg]
synonym: "down regulation of aggregate size" EXACT []
synonym: "down-regulation of aggregate size" EXACT []
synonym: "downregulation of aggregate size" EXACT []
synonym: "inhibition of aggregate size" NARROW []
is_a: GO:0031157 ! regulation of aggregate size involved in sorocarp development

[Term]
id: GO:0031159
name: positive regulation of aggregate size involved in sorocarp development
namespace: biological_process
def: "Any process that increases the size of the aggregate formed during sorocarp formation." [DDB_REF:5048 "DictyBase paper repository", GOC:mah, GOC:pg]
synonym: "activation of aggregate size" NARROW []
synonym: "stimulation of aggregate size" NARROW []
synonym: "up regulation of aggregate size" EXACT []
synonym: "up-regulation of aggregate size" EXACT []
synonym: "upregulation of aggregate size" EXACT []
is_a: GO:0031157 ! regulation of aggregate size involved in sorocarp development

[Term]
id: GO:0031160
name: spore wall
namespace: cellular_component
def: "The specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg]
synonym: "spore coat" EXACT []
is_a: GO:0005618 ! cell wall

[Term]
id: GO:0031161
name: phosphatidylinositol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [GOC:mah]
synonym: "phosphatidylinositol breakdown" EXACT []
synonym: "phosphatidylinositol catabolism" EXACT []
synonym: "phosphatidylinositol degradation" EXACT []
synonym: "PtdIns catabolic process" EXACT []
synonym: "PtdIns catabolism" EXACT []
is_a: GO:0046475 ! glycerophospholipid catabolic process
is_a: GO:0046488 ! phosphatidylinositol metabolic process

[Term]
id: GO:0031162
name: sulfur incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of exogenous sulfur into a metallo-sulfur cluster." [GOC:mah]
synonym: "sulphur incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0043687 ! post-translational protein modification
relationship: part_of GO:0031163 ! metallo-sulfur cluster assembly

[Term]
id: GO:0031163
name: metallo-sulfur cluster assembly
namespace: biological_process
def: "The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster." [GOC:mah]
subset: gosubset_prok
synonym: "metallo-sulfur cluster biosynthesis" EXACT []
synonym: "metallo-sulphur cluster assembly" EXACT []
is_a: GO:0051188 ! cofactor biosynthetic process

[Term]
id: GO:0031164
name: contractile vacuolar membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the contractile vacuole." [GOC:pg]
is_a: GO:0005774 ! vacuolar membrane
relationship: part_of GO:0000331 ! contractile vacuole

[Term]
id: GO:0031165
name: integral to contractile vacuolar membrane
namespace: cellular_component
def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the contractile vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:pg]
is_a: GO:0031166 ! integral to vacuolar membrane
is_a: GO:0031311 ! intrinsic to contractile vacuolar membrane

[Term]
id: GO:0031166
name: integral to vacuolar membrane
namespace: cellular_component
def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031301 ! integral to organelle membrane
is_a: GO:0031310 ! intrinsic to vacuolar membrane

[Term]
id: GO:0031167
name: rRNA methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah]
is_a: GO:0000154 ! rRNA modification
is_a: GO:0001510 ! RNA methylation

[Term]
id: GO:0031168
name: ferrichrome metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "ferrichrome metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process

[Term]
id: GO:0031169
name: ferrichrome biosynthetic process
namespace: biological_process
alt_id: GO:0031199
alt_id: GO:0031200
def: "The chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "ferrichrome anabolism" EXACT []
synonym: "ferrichrome biosynthesis" EXACT []
synonym: "ferrichrome biosynthetic process, peptide formation" NARROW []
synonym: "ferrichrome biosynthetic process, peptide modification" NARROW []
synonym: "ferrichrome formation" EXACT []
synonym: "ferrichrome synthesis" EXACT []
is_a: GO:0019539 ! siderophore biosynthetic process from hydroxamic acid
is_a: GO:0031168 ! ferrichrome metabolic process

[Term]
id: GO:0031170
name: ferricrocin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3." [GOC:mah, PMID:12828635]
synonym: "ferricrocin metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process

[Term]
id: GO:0031171
name: ferricrocin biosynthetic process
namespace: biological_process
alt_id: GO:0031185
alt_id: GO:0031186
def: "The chemical reactions and pathways resulting in the formation of ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3." [GOC:mah, PMID:12828635]
synonym: "ferricrocin anabolism" EXACT []
synonym: "ferricrocin biosynthesis" EXACT []
synonym: "ferricrocin biosynthetic process, peptide formation" NARROW []
synonym: "ferricrocin biosynthetic process, peptide modification" NARROW []
synonym: "ferricrocin formation" EXACT []
synonym: "ferricrocin synthesis" EXACT []
is_a: GO:0019290 ! siderophore biosynthetic process
is_a: GO:0031170 ! ferricrocin metabolic process

[Term]
id: GO:0031172
name: ornithine N5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine + O2 + donor-H2 = N5-hydroxy-L-ornithine + acceptor + H2O." [GOC:mah, PMID:12828635]
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0031173
name: otolith mineralization completed early in development
namespace: biological_process
def: "The formation of otoliths during embryogenesis with completion in early postembryonic development. Formation occurs by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia (otoliths) are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear." [GOC:dsf, PMID:15581873]
synonym: "otoconia mineralization" EXACT []
synonym: "otoconium mineralization" EXACT []
is_a: GO:0045299 ! otolith mineralization

[Term]
id: GO:0031174
name: lifelong otolith mineralization
namespace: biological_process
def: "The formation and growth of otoliths throughout the life of the organism. Otoliths are the large extracellular ear-stones of the fish inner ear, produced by precipitation of specific crystal forms of calcium carbonate on organic matrices. The otolith enlarges throughout the life of the fish, as layers of calcium carbonate are added." [GOC:dsf, PMID:15581873]
is_a: GO:0045299 ! otolith mineralization

[Term]
id: GO:0031175
name: neuron projection development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah]
synonym: "neurite biosynthesis" NARROW []
synonym: "neurite development" NARROW [GOC:dph]
synonym: "neurite formation" NARROW []
synonym: "neurite growth" NARROW []
is_a: GO:0030030 ! cell projection organization
relationship: part_of GO:0048666 ! neuron development

[Term]
id: GO:0031176
name: endo-1,4-beta-xylanase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8]
synonym: "1,4-beta-D-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8]
synonym: "1,4-beta-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8]
synonym: "beta-1,4-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8]
synonym: "beta-1,4-xylanase activity" EXACT [EC:3.2.1.8]
synonym: "beta-D-xylanase activity" EXACT [EC:3.2.1.8]
synonym: "beta-xylanase activity" EXACT [EC:3.2.1.8]
synonym: "endo-(1->4)-beta-xylanase(1->4)-beta-xylan 4-xylanohydrolase activity" EXACT [EC:3.2.1.8]
synonym: "endo-1,4-b-xylanase activity" EXACT []
synonym: "endo-1,4-beta-D-xylanase activity" EXACT [EC:3.2.1.8]
synonym: "endo-1,4-xylanase activity" EXACT [EC:3.2.1.8]
synonym: "endo-beta-1,4-xylanase activity" EXACT [EC:3.2.1.8]
synonym: "xylanase" BROAD [EC:3.2.1.8]
xref: EC:3.2.1.8
xref: MetaCyc:3.2.1.8-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0031177
name: phosphopantetheine binding
namespace: molecular_function
def: "Interacting selectizely with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [ChEBI:16858, GOC:mah]
is_a: GO:0016597 ! amino acid binding
is_a: GO:0019842 ! vitamin binding

[Term]
id: GO:0031179
name: peptide modification
namespace: biological_process
def: "The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006518 ! peptide metabolic process

[Term]
id: GO:0031201
name: SNARE complex
namespace: cellular_component
def: "A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [PMID:10872468]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0031203
name: posttranslational protein targeting to membrane, docking
namespace: biological_process
def: "The process by which the signal sequence of a translated protein binds to and forms a complex with the Sec complex." [PMID:12518217, PMID:8707814]
synonym: "posttranslational protein membrane targeting, docking" EXACT []
synonym: "protein docking during posttranslational protein targeting to membrane" EXACT []
synonym: "Sec-translated protein complex assembly" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0006620 ! posttranslational protein targeting to membrane

[Term]
id: GO:0031204
name: posttranslational protein targeting to membrane, translocation
namespace: biological_process
def: "The process by which a protein translocates through the ER membrane posttranslationally." [PMID:12518317, PMID:8707814]
synonym: "posttranslational protein membrane targeting, translocation" EXACT []
synonym: "protein translocation during posttranslational protein targeting to membrane" EXACT []
is_a: GO:0065002 ! intracellular protein transmembrane transport
relationship: part_of GO:0006620 ! posttranslational protein targeting to membrane

[Term]
id: GO:0031205
name: endoplasmic reticulum Sec complex
namespace: cellular_component
def: "An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex." [GOC:mtg_sensu, PMID:12158317, PMID:14617809]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane

[Term]
id: GO:0031207
name: Sec62/Sec63 complex
namespace: cellular_component
def: "A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p." [PMID:12518317, PMID:14617809]
synonym: "ER protein translocation subcomplex " EXACT []
synonym: "Sec62/63 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0031205 ! endoplasmic reticulum Sec complex

[Term]
id: GO:0031208
name: POZ domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." [PMID:7958847]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0031209
name: SCAR complex
namespace: cellular_component
def: "A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:pg, PMID:12181570]
synonym: "WAVE complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031210
name: phosphatidylcholine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0005543 ! phospholipid binding
is_a: GO:0043169 ! cation binding
is_a: GO:0043176 ! amine binding
is_a: GO:0043178 ! alcohol binding
is_a: GO:0050997 ! quaternary ammonium group binding

[Term]
id: GO:0031211
name: palmitoyltransferase complex
namespace: cellular_component
def: "A dimeric complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue." [GOC:jh]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0031213
name: RSF complex
namespace: cellular_component
def: "A chromatin remodeling complex that mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In humans, the complex is composed of the ATPase hSNF2H and the HBXAP protein (RSF-1)." [PMID:12972596]
synonym: "remodeling and spacing factor complex " EXACT []
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0031214
name: biomineral formation
namespace: biological_process
def: "Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation." [PMID:15132736]
synonym: "biomineralization" EXACT []
synonym: "mineralization" EXACT []
xref: Wikipedia:Biomineralisation
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0031215
name: shell calcification
namespace: biological_process
def: "The precipitation of calcium carbonate onto the organic matrix of a shell, such as a mollusc shell." [GOC:mah, PMID:15132736]
is_a: GO:0031214 ! biomineral formation

[Term]
id: GO:0031216
name: neopullulanase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of pullulan to panose (6-a-D-glucosylmaltose)." [EC:3.2.1.135, GOC:mlg]
synonym: "pullulan 4-D-glucanohydrolase (panose-forming)" EXACT [EC:3.2.1.135]
synonym: "pullulanase II activity" EXACT []
xref: EC:3.2.1.135
xref: MetaCyc:3.2.1.135-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0031217
name: glucan 1,4-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of 1,4-linkages in 1,4-beta-D-glucans, to remove successive glucose units." [EC:3.2.1.74, GOC:mlg]
synonym: "1,4-beta-D-glucan glucohydrolase activity" EXACT [EC:3.2.1.74]
synonym: "beta-1,4-beta-glucanase activity" EXACT [EC:3.2.1.74]
synonym: "beta-1,4-glucanase activity" EXACT []
synonym: "exo-1,4-beta-D-glucosidase activity" EXACT [EC:3.2.1.74]
synonym: "exo-1,4-beta-glucanase activity" EXACT []
synonym: "exo-1,4-beta-glucosidase activity" EXACT []
synonym: "exo-beta-1,4-glucanase activity" EXACT []
synonym: "exo-beta-1,4-glucosidase activity" EXACT []
synonym: "exocellulase activity" EXACT []
xref: EC:3.2.1.74
xref: MetaCyc:3.2.1.74-RXN
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0031218
name: arabinogalactan endo-1,4-beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,4-beta-D-galactosidic linkages in arabinogalactans." [EC:3.2.1.89, GOC:mlg]
synonym: "arabinogalactan 4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.89]
synonym: "arabinogalactanase activity" EXACT []
synonym: "endo-1,4-beta-galactanase activity" EXACT []
synonym: "galactanase activity" EXACT []
xref: EC:3.2.1.89
xref: MetaCyc:3.2.1.89-RXN
is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds

[Term]
id: GO:0031219
name: levanase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units." [EC:3.2.1.65, GOC:mlg]
synonym: "2,6-beta-D-fructan fructanohydrolase activity" EXACT [EC:3.2.1.65]
synonym: "levan hydrolase activity" EXACT []
xref: EC:3.2.1.65
xref: MetaCyc:3.2.1.65-RXN
is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds

[Term]
id: GO:0031220
name: maltodextrin phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: maltodextrin = glucose-1-phosphate." [GOC:mlg, PMID:10348846]
xref: MetaCyc:RXN-9025
xref: MetaCyc:RXN0-5182
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0031221
name: arabinan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arabinan, a branched homopolymer of L-arabinose." [GOC:mlg, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "arabinan metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0031222
name: arabinan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arabinan, a branched homopolymer of L-arabinose." [GOC:mlg, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "arabinan breakdown" EXACT []
synonym: "arabinan catabolism" EXACT []
synonym: "arabinan degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0031221 ! arabinan metabolic process

[Term]
id: GO:0031223
name: auditory behavior
namespace: biological_process
def: "The actions or reactions of an organism in response to a sound." [GOC:rc]
synonym: "auditory behaviour" EXACT []
synonym: "behavioral response to sound" EXACT []
synonym: "behavioural response to sound" EXACT []
is_a: GO:0007638 ! mechanosensory behavior

[Term]
id: GO:0031224
name: intrinsic to membrane
namespace: cellular_component
def: "Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
comment: Note that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent.
subset: gosubset_prok
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0031225
name: anchored to membrane
namespace: cellular_component
def: "Tethered to a membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane. When used to describe a protein, indicates that none of the peptide sequence is embedded in the membrane." [GOC:mah]
is_a: GO:0031224 ! intrinsic to membrane

[Term]
id: GO:0031226
name: intrinsic to plasma membrane
namespace: cellular_component
def: "Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
subset: gosubset_prok
is_a: GO:0031224 ! intrinsic to membrane
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0031227
name: intrinsic to endoplasmic reticulum membrane
namespace: cellular_component
def: "Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0031228
name: intrinsic to Golgi membrane
namespace: cellular_component
def: "Located in the Golgi membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0000139 ! Golgi membrane

[Term]
id: GO:0031229
name: intrinsic to nuclear inner membrane
namespace: cellular_component
def: "Located in the nuclear inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044453 ! nuclear membrane part
relationship: part_of GO:0005637 ! nuclear inner membrane

[Term]
id: GO:0031230
name: intrinsic to cell outer membrane
namespace: cellular_component
def: "Located in the cell outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
is_a: GO:0031224 ! intrinsic to membrane
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0009279 ! cell outer membrane

[Term]
id: GO:0031231
name: intrinsic to peroxisomal membrane
namespace: cellular_component
def: "Located in the peroxisomal membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044439 ! peroxisomal part
relationship: part_of GO:0005778 ! peroxisomal membrane

[Term]
id: GO:0031232
name: extrinsic to external side of plasma membrane
namespace: cellular_component
def: "Loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0019897 ! extrinsic to plasma membrane
relationship: part_of GO:0009897 ! external side of plasma membrane

[Term]
id: GO:0031233
name: intrinsic to external side of plasma membrane
namespace: cellular_component
def: "Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm." [GOC:mah]
is_a: GO:0031226 ! intrinsic to plasma membrane
relationship: part_of GO:0009897 ! external side of plasma membrane

[Term]
id: GO:0031234
name: extrinsic to internal side of plasma membrane
namespace: cellular_component
def: "Loosely bound to the surface of the plasma membrane that faces the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0019897 ! extrinsic to plasma membrane
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0009898 ! internal side of plasma membrane

[Term]
id: GO:0031235
name: intrinsic to internal side of plasma membrane
namespace: cellular_component
def: "Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side that faces the cytoplasm." [GOC:mah]
is_a: GO:0031226 ! intrinsic to plasma membrane
relationship: part_of GO:0009898 ! internal side of plasma membrane

[Term]
id: GO:0031236
name: extrinsic to external side of plasma membrane, in periplasmic space
namespace: cellular_component
alt_id: GO:0031238
def: "Located in the periplasmic space and loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
is_a: GO:0031232 ! extrinsic to external side of plasma membrane
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0030288 ! outer membrane-bounded periplasmic space

[Term]
id: GO:0031237
name: intrinsic to external side of plasma membrane, in periplasmic space
namespace: cellular_component
alt_id: GO:0031239
def: "Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located in the periplasmic space." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
is_a: GO:0031233 ! intrinsic to external side of plasma membrane
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0030288 ! outer membrane-bounded periplasmic space

[Term]
id: GO:0031240
name: external side of cell outer membrane
namespace: cellular_component
def: "The side of the outer membrane that is opposite to the side that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "external side of outer membrane" RELATED []
is_a: GO:0044425 ! membrane part
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0009279 ! cell outer membrane

[Term]
id: GO:0031241
name: internal side of cell outer membrane
namespace: cellular_component
def: "The side of the outer membrane that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "internal side of outer membrane" EXACT []
is_a: GO:0044425 ! membrane part
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0009279 ! cell outer membrane

[Term]
id: GO:0031242
name: extrinsic to external side of cell outer membrane
namespace: cellular_component
def: "Loosely bound to the surface of the outer membrane of the cell that faces away from the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "extrinsic to external side of outer membrane" EXACT []
is_a: GO:0031244 ! extrinsic to cell outer membrane
relationship: part_of GO:0031240 ! external side of cell outer membrane

[Term]
id: GO:0031243
name: intrinsic to external side of cell outer membrane
namespace: cellular_component
def: "Located in the outer membrane of the cell such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side opposite to the side that faces the periplasm." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "intrinsic to external side of outer membrane" EXACT []
is_a: GO:0031230 ! intrinsic to cell outer membrane
relationship: part_of GO:0031240 ! external side of cell outer membrane

[Term]
id: GO:0031244
name: extrinsic to cell outer membrane
namespace: cellular_component
def: "Loosely bound to one surface of the outer membrane of the cell, but not integrated into the hydrophobic region." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
is_a: GO:0019898 ! extrinsic to membrane
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0009279 ! cell outer membrane

[Term]
id: GO:0031245
name: extrinsic to internal side of cell outer membrane
namespace: cellular_component
def: "Loosely bound to the surface of the outer membrane of the cell that faces the cytoplasm, but not integrated into the hydrophobic region." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "extrinsic to internal side of outer membrane" EXACT []
is_a: GO:0031244 ! extrinsic to cell outer membrane
relationship: part_of GO:0031241 ! internal side of cell outer membrane

[Term]
id: GO:0031246
name: intrinsic to internal side of cell outer membrane
namespace: cellular_component
def: "Located in the outer membrane of the cell such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side that faces the periplasm." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "intrinsic to internal side of outer membrane" EXACT []
is_a: GO:0031230 ! intrinsic to cell outer membrane
relationship: part_of GO:0031241 ! internal side of cell outer membrane

[Term]
id: GO:0031247
name: actin rod assembly
namespace: biological_process
def: "The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules." [GOC:pg, PMID:14706699]
synonym: "actin rod formation" RELATED [GOC:mah]
is_a: GO:0007015 ! actin filament organization
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0031248
name: protein acetyltransferase complex
namespace: cellular_component
def: "A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031249
name: denatured protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with denatured proteins." [GOC:mlg]
comment: Note that this term should not be confused with 'unfolded protein binding ; GO:0051082', which usually refers to proteins that have not yet folded into their active states. Denatured proteins once were in their correct functional conformations, but have become incorrectly folded, and often form aggregates.
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031250
name: anaerobic ribonucleoside-triphosphate reductase complex
namespace: cellular_component
def: "An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit." [GOC:mlg]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031251
name: PAN complex
namespace: cellular_component
def: "A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670]
synonym: "poly(A) nuclease complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031252
name: cell leading edge
namespace: cellular_component
def: "The area of a motile cell closest to the direction of movement." [GOC:pg]
subset: goslim_pir
synonym: "front of cell" EXACT []
synonym: "leading edge of cell" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031253
name: cell projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a cell surface projection." [GOC:mah]
synonym: "membrane extension" RELATED []
synonym: "membrane projection" RELATED []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0044463 ! cell projection part

[Term]
id: GO:0031254
name: trailing edge
namespace: cellular_component
def: "The area of a motile cell opposite to the direction of movement." [GOC:pg]
subset: goslim_pir
synonym: "back of cell" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031255
name: lateral part of motile cell
namespace: cellular_component
def: "The area of a motile cell perpendicular to the direction of movement." [GOC:pg]
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031256
name: leading edge membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0031257
name: trailing edge membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the trailing edge of a motile cell." [GOC:mah]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0031254 ! trailing edge

[Term]
id: GO:0031258
name: lamellipodium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a lamellipodium." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0031256 ! leading edge membrane
relationship: part_of GO:0030027 ! lamellipodium

[Term]
id: GO:0031259
name: uropod membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a uropod." [GOC:mah]
synonym: "uropodium membrane" EXACT []
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0031257 ! trailing edge membrane
relationship: part_of GO:0001931 ! uropod

[Term]
id: GO:0031260
name: pseudopodium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a pseudopodium." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0031143 ! pseudopodium

[Term]
id: GO:0031261
name: DNA replication preinitiation complex
namespace: cellular_component
def: "A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:vw, PMID:12694535, PMID:15194812]
synonym: "pre-IC" EXACT []
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0031262
name: Ndc80 complex
namespace: cellular_component
def: "A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore." [PMID:15509863, PMID:15661517]
synonym: "Nuf2-Ndc80 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000776 ! kinetochore

[Term]
id: GO:0031263
name: amine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + amine(out) = ADP + phosphate + amine(in)." [GOC:mlg]
subset: gosubset_prok
synonym: "amine ABC transporter" NARROW []
is_a: GO:0005275 ! amine transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0031264
name: death-inducing signaling complex
namespace: cellular_component
def: "A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293]
subset: goslim_pir
synonym: "death-inducing signalling complex" EXACT []
synonym: "DISC" EXACT []
xref: Wikipedia:Death-inducing_signaling_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0031265
name: CD95 death-inducing signaling complex
namespace: cellular_component
def: "A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293]
synonym: "CD95 death-inducing signalling complex" EXACT []
synonym: "CD95 DISC" EXACT []
synonym: "Fas death-inducing signaling complex" EXACT []
is_a: GO:0031264 ! death-inducing signaling complex

[Term]
id: GO:0031266
name: TRAIL death-inducing signaling complex
namespace: cellular_component
def: "A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293]
synonym: "TRAIL death-inducing signalling complex" EXACT []
synonym: "TRAIL DISC" EXACT []
is_a: GO:0031264 ! death-inducing signaling complex

[Term]
id: GO:0031267
name: small GTPase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a small monomeric GTPase." [GOC:mah]
is_a: GO:0051020 ! GTPase binding

[Term]
id: GO:0031268
name: pseudopodium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement." [GOC:pg]
synonym: "pseudopodium organisation" EXACT [GOC:curators]
synonym: "pseudopodium organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0031269
name: pseudopodium assembly
namespace: biological_process
def: "The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane." [GOC:dph, GOC:mah, GOC:pg, GOC:tb]
synonym: "pseudopodium extension" EXACT []
synonym: "pseudopodium formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0031268 ! pseudopodium organization

[Term]
id: GO:0031270
name: pseudopodium retraction
namespace: biological_process
def: "The myosin-based contraction and retraction of the pseudopodium." [GOC:pg]
is_a: GO:0031268 ! pseudopodium organization

[Term]
id: GO:0031271
name: lateral pseudopodium assembly
namespace: biological_process
def: "The extension of a pseudopodium from the lateral area of a cell." [GOC:dph, GOC:mah, GOC:pg, GOC:tb]
synonym: "lateral pseudopodium formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0031269 ! pseudopodium assembly

[Term]
id: GO:0031272
name: regulation of pseudopodium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg]
synonym: "regulation of pseudopodium formation" RELATED []
is_a: GO:0060491 ! regulation of cell projection assembly
relationship: regulates GO:0031269 ! pseudopodium assembly

[Term]
id: GO:0031273
name: negative regulation of pseudopodium assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg]
synonym: "down regulation of pseudopodium formation" RELATED []
synonym: "down-regulation of pseudopodium formation" RELATED []
synonym: "downregulation of pseudopodium formation" RELATED []
synonym: "inhibition of pseudopodium formation" NARROW []
synonym: "negative regulation of pseudopodium formation" RELATED []
is_a: GO:0031272 ! regulation of pseudopodium assembly
is_a: GO:0031345 ! negative regulation of cell projection organization
relationship: negatively_regulates GO:0031269 ! pseudopodium assembly

[Term]
id: GO:0031274
name: positive regulation of pseudopodium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg]
synonym: "activation of pseudopodium formation" NARROW []
synonym: "positive regulation of pseudopodium formation" RELATED [GOC:dph]
synonym: "stimulation of pseudopodium formation" NARROW []
synonym: "up regulation of pseudopodium formation" RELATED []
synonym: "up-regulation of pseudopodium formation" RELATED []
synonym: "upregulation of pseudopodium formation" RELATED []
is_a: GO:0031272 ! regulation of pseudopodium assembly
is_a: GO:0031346 ! positive regulation of cell projection organization
relationship: positively_regulates GO:0031269 ! pseudopodium assembly

[Term]
id: GO:0031275
name: regulation of lateral pseudopodium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb]
synonym: "regulation of lateral pseudopodium formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031272 ! regulation of pseudopodium assembly
relationship: regulates GO:0031271 ! lateral pseudopodium assembly

[Term]
id: GO:0031276
name: negative regulation of lateral pseudopodium assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb]
synonym: "down regulation of lateral pseudopodium formation" RELATED []
synonym: "down-regulation of lateral pseudopodium formation" RELATED []
synonym: "downregulation of lateral pseudopodium formation" RELATED []
synonym: "inhibition of lateral pseudopodium formation" NARROW []
synonym: "negative regulation of lateral pseudopodium formation" RELATED [GOC:dph]
is_a: GO:0031273 ! negative regulation of pseudopodium assembly
is_a: GO:0031275 ! regulation of lateral pseudopodium assembly
relationship: negatively_regulates GO:0031271 ! lateral pseudopodium assembly

[Term]
id: GO:0031277
name: positive regulation of lateral pseudopodium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb]
synonym: "activation of lateral pseudopodium formation" NARROW []
synonym: "positive regulation of lateral pseudopodium formation" RELATED []
synonym: "stimulation of lateral pseudopodium formation" NARROW []
synonym: "up regulation of lateral pseudopodium formation" RELATED []
synonym: "up-regulation of lateral pseudopodium formation" RELATED []
synonym: "upregulation of lateral pseudopodium formation" RELATED []
is_a: GO:0031274 ! positive regulation of pseudopodium assembly
is_a: GO:0031275 ! regulation of lateral pseudopodium assembly
relationship: positively_regulates GO:0031271 ! lateral pseudopodium assembly

[Term]
id: GO:0031278
name: alpha-1,2-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage." [PMID:7522655]
xref: EC:2.4.1.-
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0031279
name: regulation of cyclase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclase activity." [GOC:mah]
subset: gosubset_prok
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0031280
name: negative regulation of cyclase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a cyclase." [GOC:mah]
synonym: "down regulation of cyclase activity" EXACT []
synonym: "down-regulation of cyclase activity" EXACT []
synonym: "downregulation of cyclase activity" EXACT []
synonym: "inhibition of cyclase activity" NARROW []
is_a: GO:0031279 ! regulation of cyclase activity
is_a: GO:0043086 ! negative regulation of catalytic activity

[Term]
id: GO:0031281
name: positive regulation of cyclase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a cyclase." [GOC:mah]
synonym: "activation of cyclase activity" NARROW []
synonym: "stimulation of cyclase activity" NARROW []
synonym: "up regulation of cyclase activity" EXACT []
synonym: "up-regulation of cyclase activity" EXACT []
synonym: "upregulation of cyclase activity" EXACT []
is_a: GO:0031279 ! regulation of cyclase activity
is_a: GO:0043085 ! positive regulation of catalytic activity

[Term]
id: GO:0031282
name: regulation of guanylate cyclase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of guanylate cyclase activity." [GOC:mah]
is_a: GO:0030826 ! regulation of cGMP biosynthetic process
is_a: GO:0031279 ! regulation of cyclase activity
is_a: GO:0051339 ! regulation of lyase activity

[Term]
id: GO:0031283
name: negative regulation of guanylate cyclase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of guanylate cyclase activity." [GOC:mah]
synonym: "down regulation of guanylate cyclase activity" EXACT []
synonym: "down-regulation of guanylate cyclase activity" EXACT []
synonym: "downregulation of guanylate cyclase activity" EXACT []
synonym: "inhibition of guanylate cyclase activity" NARROW []
is_a: GO:0031280 ! negative regulation of cyclase activity
is_a: GO:0031282 ! regulation of guanylate cyclase activity
is_a: GO:0051350 ! negative regulation of lyase activity

[Term]
id: GO:0031284
name: positive regulation of guanylate cyclase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity." [GOC:mah]
synonym: "activation of guanylate cyclase activity" NARROW []
synonym: "stimulation of guanylate cyclase activity" NARROW []
synonym: "up regulation of guanylate cyclase activity" EXACT []
synonym: "up-regulation of guanylate cyclase activity" EXACT []
synonym: "upregulation of guanylate cyclase activity" EXACT []
is_a: GO:0031281 ! positive regulation of cyclase activity
is_a: GO:0031282 ! regulation of guanylate cyclase activity
is_a: GO:0051349 ! positive regulation of lyase activity

[Term]
id: GO:0031285
name: regulation of sorocarp stalk cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [DDB_REF:5048 "DictyBase paper repository", GOC:kp, GOC:mtg_sensu]
synonym: "regulation of stalk cell differentiation" EXACT []
is_a: GO:0031156 ! regulation of sorocarp development
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0031149 ! sorocarp stalk cell differentiation

[Term]
id: GO:0031286
name: negative regulation of sorocarp stalk cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [DDB_REF:5048 "DictyBase paper repository", GOC:kp, GOC:mtg_sensu]
synonym: "down regulation of stalk cell differentiation" EXACT []
synonym: "down-regulation of stalk cell differentiation" EXACT []
synonym: "downregulation of stalk cell differentiation" EXACT []
synonym: "inhibition of stalk cell differentiation" NARROW []
synonym: "negative regulation of stalk cell differentiation" EXACT []
is_a: GO:0031285 ! regulation of sorocarp stalk cell differentiation
is_a: GO:0032108 ! negative regulation of response to nutrient levels
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
relationship: negatively_regulates GO:0031149 ! sorocarp stalk cell differentiation

[Term]
id: GO:0031287
name: positive regulation of sorocarp stalk cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [DDB_REF:5048 "DictyBase paper repository", GOC:kp, GOC:mtg_sensu]
synonym: "activation of stalk cell differentiation" NARROW []
synonym: "positive regulation of stalk cell differentiation" EXACT []
synonym: "stimulation of stalk cell differentiation" NARROW []
synonym: "up regulation of stalk cell differentiation" EXACT []
synonym: "up-regulation of stalk cell differentiation" EXACT []
synonym: "upregulation of stalk cell differentiation" EXACT []
is_a: GO:0031285 ! regulation of sorocarp stalk cell differentiation
is_a: GO:0032109 ! positive regulation of response to nutrient levels
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
relationship: positively_regulates GO:0031149 ! sorocarp stalk cell differentiation

[Term]
id: GO:0031288
name: sorocarp morphogenesis
namespace: biological_process
def: "The process by which the sorocarp is generated and organized. Morphogenesis pertains to the creation of form. An example of this process is found in Dictyostelium discoideum." [DDB_REF:5048 "DictyBase paper repository", GOC:kp, GOC:mtg_sensu]
synonym: "fruiting body morphogenesis" BROAD []
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0030587 ! sorocarp development

[Term]
id: GO:0031289
name: actin phosphorylation
namespace: biological_process
def: "The transfer of one or more phosphate groups to an actin molecule." [GOC:mah]
is_a: GO:0006468 ! protein amino acid phosphorylation
is_a: GO:0030047 ! actin modification

[Term]
id: GO:0031290
name: retinal ganglion cell axon guidance
namespace: biological_process
def: "The process by which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs]
synonym: "retinal ganglion cell axon pathfinding" EXACT []
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0031291
name: Ran protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state." [GOC:mah]
is_a: GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0031292
name: gene conversion at mating-type locus, DNA double-strand break processing
namespace: biological_process
def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break at the mating-type locus to form a 3' single-strand DNA overhang." [GOC:mah]
is_a: GO:0000729 ! DNA double-strand break processing
relationship: part_of GO:0007534 ! gene conversion at mating-type locus

[Term]
id: GO:0031293
name: membrane protein intracellular domain proteolysis
namespace: biological_process
def: "The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain." [PMID:12808018]
synonym: "membrane protein solubilization" RELATED []
xref: Reactome:193692 "Regulated proteolysis of p75NTR"
xref: Reactome:448796 "Regulated proteolysis of p75NTR"
xref: Reactome:469912 "Regulated proteolysis of p75NTR"
xref: Reactome:487618 "Regulated proteolysis of p75NTR"
xref: Reactome:507573 "Regulated proteolysis of p75NTR"
is_a: GO:0033619 ! membrane protein proteolysis

[Term]
id: GO:0031294
name: lymphocyte costimulation
namespace: biological_process
def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "lymphocyte co-stimulation" EXACT []
is_a: GO:0002376 ! immune system process
is_a: GO:0051251 ! positive regulation of lymphocyte activation

[Term]
id: GO:0031295
name: T cell costimulation
namespace: biological_process
def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "T cell co-stimulation" EXACT []
synonym: "T lymphocyte costimulation" EXACT []
synonym: "T-cell co-stimulation" EXACT []
synonym: "T-cell costimulation" EXACT []
synonym: "T-lymphocyte costimulation" EXACT []
is_a: GO:0031294 ! lymphocyte costimulation
is_a: GO:0050870 ! positive regulation of T cell activation

[Term]
id: GO:0031296
name: B cell costimulation
namespace: biological_process
def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "B cell co-stimulation " EXACT []
synonym: "B lymphocyte co-stimulation" EXACT []
synonym: "B lymphocyte costimulation" EXACT []
synonym: "B-cell co-stimulation" EXACT []
synonym: "B-cell costimulation" EXACT []
synonym: "B-lymphocyte co-stimulation" EXACT []
synonym: "B-lymphocyte costimulation" EXACT []
is_a: GO:0031294 ! lymphocyte costimulation
is_a: GO:0050871 ! positive regulation of B cell activation

[Term]
id: GO:0031297
name: replication fork processing
namespace: biological_process
def: "The process by which a DNA replication fork that has stalled (due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes) is repaired and replication is restarted." [PMID:11459955, PMID:15367656, PMID:17660542]
synonym: "collapsed replication fork processing" EXACT []
synonym: "recovery from replication fork arrest" EXACT []
synonym: "recovery from replication fork stalling" EXACT []
is_a: GO:0006974 ! response to DNA damage stimulus
is_a: GO:0045005 ! maintenance of fidelity during DNA-dependent DNA replication

[Term]
id: GO:0031298
name: replication fork protection complex
namespace: cellular_component
def: "A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling." [PMID:15367656]
synonym: "replisome progression complex" EXACT [GOC:vw]
synonym: "Swi1-Swi3 complex" NARROW []
synonym: "TIMELESS-TIPIN complex" NARROW [GOC:mah, GOC:vw]
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043596 ! nuclear replication fork

[Term]
id: GO:0031299
name: taurine-pyruvate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde." [EC:2.6.1.77]
synonym: "taurine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.77]
synonym: "Tpa" RELATED [EC:2.6.1.77]
xref: EC:2.6.1.77
xref: MetaCyc:TAURINE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0031300
name: intrinsic to organelle membrane
namespace: cellular_component
def: "Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031224 ! intrinsic to membrane
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0031090 ! organelle membrane

[Term]
id: GO:0031301
name: integral to organelle membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0016021 ! integral to membrane
is_a: GO:0031300 ! intrinsic to organelle membrane

[Term]
id: GO:0031302
name: intrinsic to endosome membrane
namespace: cellular_component
def: "Located in the endosome membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0031303
name: integral to endosome membrane
namespace: cellular_component
def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the endosome membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031301 ! integral to organelle membrane
is_a: GO:0031302 ! intrinsic to endosome membrane

[Term]
id: GO:0031304
name: intrinsic to mitochondrial inner membrane
namespace: cellular_component
def: "Located in the mitochondrial inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0031305
name: integral to mitochondrial inner membrane
namespace: cellular_component
def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the mitochondrial inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031304 ! intrinsic to mitochondrial inner membrane
is_a: GO:0032592 ! integral to mitochondrial membrane

[Term]
id: GO:0031306
name: intrinsic to mitochondrial outer membrane
namespace: cellular_component
def: "Located in the mitochondrial outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005741 ! mitochondrial outer membrane

[Term]
id: GO:0031307
name: integral to mitochondrial outer membrane
namespace: cellular_component
def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the mitochondrial outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031306 ! intrinsic to mitochondrial outer membrane
is_a: GO:0032592 ! integral to mitochondrial membrane

[Term]
id: GO:0031308
name: intrinsic to nuclear outer membrane
namespace: cellular_component
def: "Located in the nuclear outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044453 ! nuclear membrane part
relationship: part_of GO:0005640 ! nuclear outer membrane

[Term]
id: GO:0031309
name: integral to nuclear outer membrane
namespace: cellular_component
def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the nuclear outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031301 ! integral to organelle membrane
is_a: GO:0031308 ! intrinsic to nuclear outer membrane

[Term]
id: GO:0031310
name: intrinsic to vacuolar membrane
namespace: cellular_component
def: "Located in the vacuolar membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0031311
name: intrinsic to contractile vacuolar membrane
namespace: cellular_component
def: "Located in the contractile vacuolar membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031310 ! intrinsic to vacuolar membrane
relationship: part_of GO:0031164 ! contractile vacuolar membrane

[Term]
id: GO:0031312
name: extrinsic to organelle membrane
namespace: cellular_component
def: "Loosely bound to one surface of an organelle membrane, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0019898 ! extrinsic to membrane
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0031090 ! organelle membrane

[Term]
id: GO:0031313
name: extrinsic to endosome membrane
namespace: cellular_component
def: "Loosely bound to one surface of the endosome membrane, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0031312 ! extrinsic to organelle membrane
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0031314
name: extrinsic to mitochondrial inner membrane
namespace: cellular_component
def: "Loosely bound to one surface of the mitochondrial inner membrane, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0031312 ! extrinsic to organelle membrane
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0031315
name: extrinsic to mitochondrial outer membrane
namespace: cellular_component
def: "Loosely bound to one surface of the mitochondrial outer membrane, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0031312 ! extrinsic to organelle membrane
is_a: GO:0044455 ! mitochondrial membrane part

[Term]
id: GO:0031316
name: extrinsic to nuclear outer membrane
namespace: cellular_component
def: "Loosely bound to one surface of the nuclear outer membrane, but not integrated into the hydrophobic region." [GOC:mah]
is_a: GO:0031312 ! extrinsic to organelle membrane
is_a: GO:0044453 ! nuclear membrane part
relationship: part_of GO:0005640 ! nuclear outer membrane

[Term]
id: GO:0031317
name: tripartite ATP-independent periplasmic transporter complex
namespace: cellular_component
def: "A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients." [GOC:mlg]
subset: gosubset_prok
synonym: "TRAP transporter complex" EXACT []
synonym: "TRAP-T transporter complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031318
name: detection of folic acid
namespace: biological_process
def: "The series of events in which a folic acid stimulus is received by a cell and converted into a molecular signal." [GOC:pg]
synonym: "detection of folate" EXACT []
synonym: "folate detection" EXACT []
synonym: "folate sensing" EXACT []
synonym: "folic acid detection" EXACT []
synonym: "folic acid sensing" EXACT []
is_a: GO:0009594 ! detection of nutrient
is_a: GO:0051593 ! response to folic acid

[Term]
id: GO:0031319
name: detection of cAMP
namespace: biological_process
def: "The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP." [GOC:pg]
synonym: "3',5'-cAMP detection" EXACT []
synonym: "3',5'-cAMP sensing" EXACT []
synonym: "cAMP detection" EXACT []
synonym: "cAMP sensing" EXACT []
synonym: "cyclic AMP detection" EXACT []
synonym: "detection of 3',5' cAMP" EXACT []
synonym: "detection of 3',5'-cAMP" EXACT []
synonym: "detection of adenosine 3',5'-cyclophosphate" EXACT []
synonym: "detection of cyclic AMP" EXACT []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0051591 ! response to cAMP

[Term]
id: GO:0031320
name: hexitol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0031321
name: ascospore-type prospore formation
namespace: biological_process
def: "During ascospore formation, the process by which each haploid nucleus becomes encapsulated by a double membrane." [GOC:mah, PMID:14702385]
synonym: "forespore formation" RELATED []
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0030437 ! ascospore formation

[Term]
id: GO:0031322
name: ascospore-type prospore-specific spindle pole body modification
namespace: biological_process
def: "Structural modification of the spindle pole body that takes place during the second meiotic division during ascospore formation; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP)." [GOC:mah, PMID:14702385]
synonym: "forespore specific spindle pole body modification" EXACT []
synonym: "forespore-specific spindle pole body modification" EXACT []
synonym: "prospore specific spindle pole body modification" EXACT []
synonym: "sporulation specific spindle pole body modification " EXACT []
is_a: GO:0051300 ! spindle pole body organization
relationship: part_of GO:0031321 ! ascospore-type prospore formation

[Term]
id: GO:0031323
name: regulation of cellular metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cellular metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0044237 ! cellular metabolic process

[Term]
id: GO:0031324
name: negative regulation of cellular metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cellular metabolic process" EXACT []
synonym: "down-regulation of cellular metabolic process" EXACT []
synonym: "downregulation of cellular metabolic process" EXACT []
synonym: "inhibition of cellular metabolic process" NARROW []
synonym: "negative regulation of cellular metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0044237 ! cellular metabolic process

[Term]
id: GO:0031325
name: positive regulation of cellular metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cellular metabolic process" NARROW []
synonym: "positive regulation of cellular metabolism" EXACT []
synonym: "stimulation of cellular metabolic process" NARROW []
synonym: "up regulation of cellular metabolic process" EXACT []
synonym: "up-regulation of cellular metabolic process" EXACT []
synonym: "upregulation of cellular metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0044237 ! cellular metabolic process

[Term]
id: GO:0031326
name: regulation of cellular biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cellular anabolism" EXACT []
synonym: "regulation of cellular biosynthesis" EXACT []
synonym: "regulation of cellular formation" EXACT []
synonym: "regulation of cellular synthesis" EXACT []
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0031323 ! regulation of cellular metabolic process
relationship: regulates GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0031327
name: negative regulation of cellular biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cellular biosynthetic process" EXACT []
synonym: "down-regulation of cellular biosynthetic process" EXACT []
synonym: "downregulation of cellular biosynthetic process" EXACT []
synonym: "inhibition of cellular biosynthetic process" NARROW []
synonym: "negative regulation of cellular anabolism" EXACT []
synonym: "negative regulation of cellular biosynthesis" EXACT []
synonym: "negative regulation of cellular formation" EXACT []
synonym: "negative regulation of cellular synthesis" EXACT []
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
relationship: negatively_regulates GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0031328
name: positive regulation of cellular biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cellular biosynthetic process" NARROW []
synonym: "positive regulation of cellular anabolism" EXACT []
synonym: "positive regulation of cellular biosynthesis" EXACT []
synonym: "positive regulation of cellular formation" EXACT []
synonym: "positive regulation of cellular synthesis" EXACT []
synonym: "stimulation of cellular biosynthetic process" NARROW []
synonym: "up regulation of cellular biosynthetic process" EXACT []
synonym: "up-regulation of cellular biosynthetic process" EXACT []
synonym: "upregulation of cellular biosynthetic process" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
relationship: positively_regulates GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0031329
name: regulation of cellular catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cellular breakdown" EXACT []
synonym: "regulation of cellular catabolism" EXACT []
synonym: "regulation of cellular degradation" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
relationship: regulates GO:0044248 ! cellular catabolic process

[Term]
id: GO:0031330
name: negative regulation of cellular catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of cellular catabolic process" EXACT []
synonym: "down-regulation of cellular catabolic process" EXACT []
synonym: "downregulation of cellular catabolic process" EXACT []
synonym: "inhibition of cellular catabolic process" NARROW []
synonym: "negative regulation of cellular breakdown" EXACT []
synonym: "negative regulation of cellular catabolism" EXACT []
synonym: "negative regulation of cellular degradation" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
relationship: negatively_regulates GO:0044248 ! cellular catabolic process

[Term]
id: GO:0031331
name: positive regulation of cellular catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah]
subset: gosubset_prok
synonym: "activation of cellular catabolic process" NARROW []
synonym: "positive regulation of cellular breakdown" EXACT []
synonym: "positive regulation of cellular catabolism" EXACT []
synonym: "positive regulation of cellular degradation" EXACT []
synonym: "stimulation of cellular catabolic process" NARROW []
synonym: "up regulation of cellular catabolic process" EXACT []
synonym: "up-regulation of cellular catabolic process" EXACT []
synonym: "upregulation of cellular catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
relationship: positively_regulates GO:0044248 ! cellular catabolic process

[Term]
id: GO:0031332
name: RNAi effector complex
namespace: cellular_component
def: "Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins." [GOC:mah, PMID:14704433]
subset: goslim_pir
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0031333
name: negative regulation of protein complex assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of protein complex assembly" EXACT []
synonym: "down-regulation of protein complex assembly" EXACT []
synonym: "downregulation of protein complex assembly" EXACT []
synonym: "inhibition of protein complex assembly" NARROW []
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0006461 ! protein complex assembly

[Term]
id: GO:0031334
name: positive regulation of protein complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah]
subset: gosubset_prok
synonym: "activation of protein complex assembly" NARROW []
synonym: "stimulation of protein complex assembly" NARROW []
synonym: "up regulation of protein complex assembly" EXACT []
synonym: "up-regulation of protein complex assembly" EXACT []
synonym: "upregulation of protein complex assembly" EXACT []
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0006461 ! protein complex assembly

[Term]
id: GO:0031335
name: regulation of sulfur amino acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of sulfur amino acid metabolism" EXACT []
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
relationship: regulates GO:0000096 ! sulfur amino acid metabolic process

[Term]
id: GO:0031336
name: negative regulation of sulfur amino acid metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of sulfur amino acid metabolic process" EXACT []
synonym: "down-regulation of sulfur amino acid metabolic process" EXACT []
synonym: "downregulation of sulfur amino acid metabolic process" EXACT []
synonym: "inhibition of sulfur amino acid metabolic process" NARROW []
synonym: "negative regulation of sulfur amino acid metabolism" EXACT []
is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process
is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
relationship: negatively_regulates GO:0000096 ! sulfur amino acid metabolic process

[Term]
id: GO:0031337
name: positive regulation of sulfur amino acid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah]
subset: gosubset_prok
synonym: "activation of sulfur amino acid metabolic process" NARROW []
synonym: "positive regulation of sulfur amino acid metabolism" EXACT []
synonym: "stimulation of sulfur amino acid metabolic process" NARROW []
synonym: "up regulation of sulfur amino acid metabolic process" EXACT []
synonym: "up-regulation of sulfur amino acid metabolic process" EXACT []
synonym: "upregulation of sulfur amino acid metabolic process" EXACT []
is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process
is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
relationship: positively_regulates GO:0000096 ! sulfur amino acid metabolic process

[Term]
id: GO:0031338
name: regulation of vesicle fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vesicle fusion." [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0060627 ! regulation of vesicle-mediated transport
relationship: regulates GO:0006906 ! vesicle fusion

[Term]
id: GO:0031339
name: negative regulation of vesicle fusion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fusion." [GOC:mah]
synonym: "down regulation of vesicle fusion" EXACT []
synonym: "down-regulation of vesicle fusion" EXACT []
synonym: "downregulation of vesicle fusion" EXACT []
synonym: "inhibition of vesicle fusion" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0006906 ! vesicle fusion

[Term]
id: GO:0031340
name: positive regulation of vesicle fusion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah]
synonym: "activation of vesicle fusion" NARROW []
synonym: "stimulation of vesicle fusion" NARROW []
synonym: "up regulation of vesicle fusion" EXACT []
synonym: "up-regulation of vesicle fusion" EXACT []
synonym: "upregulation of vesicle fusion" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0006906 ! vesicle fusion

[Term]
id: GO:0031341
name: regulation of cell killing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell killing, the process by which a cell brings about the death of another cell, either in the same or a different organism." [GOC:mah]
subset: gosubset_prok
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0001906 ! cell killing

[Term]
id: GO:0031342
name: negative regulation of cell killing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell killing." [GOC:mah]
synonym: "down regulation of cell killing" EXACT []
synonym: "down-regulation of cell killing" EXACT []
synonym: "downregulation of cell killing" EXACT []
synonym: "inhibition of cell killing" NARROW []
is_a: GO:0031341 ! regulation of cell killing
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0001906 ! cell killing

[Term]
id: GO:0031343
name: positive regulation of cell killing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell killing." [GOC:mah]
synonym: "activation of cell killing" NARROW []
synonym: "stimulation of cell killing" NARROW []
synonym: "up regulation of cell killing" EXACT []
synonym: "up-regulation of cell killing" EXACT []
synonym: "upregulation of cell killing" EXACT []
is_a: GO:0031341 ! regulation of cell killing
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0001906 ! cell killing

[Term]
id: GO:0031344
name: regulation of cell projection organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cell projection organisation" EXACT [GOC:curators]
synonym: "regulation of cell projection organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0030030 ! cell projection organization

[Term]
id: GO:0031345
name: negative regulation of cell projection organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]
synonym: "down regulation of cell projection organization" EXACT [GOC:mah]
synonym: "down-regulation of cell projection organization" EXACT []
synonym: "downregulation of cell projection organization" EXACT []
synonym: "inhibition of cell projection organization" NARROW []
synonym: "negative regulation of cell projection organisation" EXACT [GOC:curators]
synonym: "negative regulation of cell projection organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0030030 ! cell projection organization

[Term]
id: GO:0031346
name: positive regulation of cell projection organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah]
synonym: "activation of cell projection organization" NARROW []
synonym: "positive regulation of cell projection organisation" EXACT [GOC:curators]
synonym: "positive regulation of cell projection organization and biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cell projection organization" NARROW []
synonym: "up regulation of cell projection organization" EXACT []
synonym: "up-regulation of cell projection organization" EXACT []
synonym: "upregulation of cell projection organization" EXACT []
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0030030 ! cell projection organization

[Term]
id: GO:0031347
name: regulation of defense response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah]
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:0006952 ! defense response

[Term]
id: GO:0031348
name: negative regulation of defense response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a defense response." [GOC:mah]
synonym: "down regulation of defense response" EXACT []
synonym: "down-regulation of defense response" EXACT []
synonym: "downregulation of defense response" EXACT []
synonym: "inhibition of defense response" NARROW []
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0006952 ! defense response

[Term]
id: GO:0031349
name: positive regulation of defense response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah]
synonym: "activation of defense response" NARROW []
synonym: "stimulation of defense response" NARROW []
synonym: "up regulation of defense response" EXACT []
synonym: "up-regulation of defense response" EXACT []
synonym: "upregulation of defense response" EXACT []
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0006952 ! defense response

[Term]
id: GO:0031350
name: intrinsic to plastid membrane
namespace: cellular_component
def: "Located in a plastid membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0042170 ! plastid membrane

[Term]
id: GO:0031351
name: integral to plastid membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a plastid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031301 ! integral to organelle membrane
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0042170 ! plastid membrane

[Term]
id: GO:0031352
name: intrinsic to plastid inner membrane
namespace: cellular_component
def: "Located in a plastid inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031350 ! intrinsic to plastid membrane
relationship: part_of GO:0009528 ! plastid inner membrane

[Term]
id: GO:0031353
name: integral to plastid inner membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a plastid inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031351 ! integral to plastid membrane
relationship: part_of GO:0009528 ! plastid inner membrane

[Term]
id: GO:0031354
name: intrinsic to plastid outer membrane
namespace: cellular_component
def: "Located in a plastid outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031350 ! intrinsic to plastid membrane
relationship: part_of GO:0009527 ! plastid outer membrane

[Term]
id: GO:0031355
name: integral to plastid outer membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a plastid outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031351 ! integral to plastid membrane
relationship: part_of GO:0009527 ! plastid outer membrane

[Term]
id: GO:0031356
name: intrinsic to chloroplast inner membrane
namespace: cellular_component
def: "Located in the chloroplast inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031352 ! intrinsic to plastid inner membrane
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009706 ! chloroplast inner membrane

[Term]
id: GO:0031357
name: integral to chloroplast inner membrane
namespace: cellular_component
def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the chloroplast inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031353 ! integral to plastid inner membrane
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009706 ! chloroplast inner membrane

[Term]
id: GO:0031358
name: intrinsic to chloroplast outer membrane
namespace: cellular_component
def: "Located in the chloroplast outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031354 ! intrinsic to plastid outer membrane
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009707 ! chloroplast outer membrane

[Term]
id: GO:0031359
name: integral to chloroplast outer membrane
namespace: cellular_component
def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the chloroplast outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031355 ! integral to plastid outer membrane
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009707 ! chloroplast outer membrane

[Term]
id: GO:0031360
name: intrinsic to thylakoid membrane
namespace: cellular_component
def: "Located in a thylakoid membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031300 ! intrinsic to organelle membrane
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0042651 ! thylakoid membrane

[Term]
id: GO:0031361
name: integral to thylakoid membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031301 ! integral to organelle membrane
is_a: GO:0044436 ! thylakoid part
relationship: part_of GO:0042651 ! thylakoid membrane

[Term]
id: GO:0031362
name: anchored to external side of plasma membrane
namespace: cellular_component
def: "Tethered to the plasma membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm. When used to describe a protein, indicates that the peptide sequence does not span the membrane." [GOC:mah]
is_a: GO:0031233 ! intrinsic to external side of plasma membrane
is_a: GO:0046658 ! anchored to plasma membrane

[Term]
id: GO:0031363
name: N-terminal protein amino acid deamination
namespace: biological_process
def: "The removal of an amino group from the N-terminal amino acid residue of a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0031365 ! N-terminal protein amino acid modification

[Term]
id: GO:0031364
name: N-terminal protein amino acid deamination, from side chain
namespace: biological_process
def: "The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein." [GOC:mah]
is_a: GO:0031363 ! N-terminal protein amino acid deamination

[Term]
id: GO:0031365
name: N-terminal protein amino acid modification
namespace: biological_process
def: "The alteration of the N-terminal amino acid residue in a protein." [GOC:mah]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0031366
name: N-terminal peptidyl-arginine deamination
namespace: biological_process
def: "The removal of an amino group from the side chain of an N-terminal asparagine residue of a protein." [GOC:mah]
is_a: GO:0031364 ! N-terminal protein amino acid deamination, from side chain

[Term]
id: GO:0031367
name: N-terminal peptidyl-glutamine deamination
namespace: biological_process
def: "The removal of an amino group from the side chain of an N-terminal glutamine residue of a protein." [GOC:mah]
is_a: GO:0031364 ! N-terminal protein amino acid deamination, from side chain

[Term]
id: GO:0031368
name: Pro-X metallocarboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid." [EC:3.4.17.16, GOC:mah]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxypeptidase P activity" NARROW [EC:3.4.17.16]
synonym: "membrane Pro-X carboxypeptidase activity" NARROW [EC:3.4.17.16]
synonym: "membrane Pro-Xaa carboxypeptidase" NARROW []
synonym: "microsomal carboxypeptidase activity" NARROW [EC:3.4.17.16]
xref: EC:3.4.17.16
is_obsolete: true
replaced_by: GO:0004181
replaced_by: GO:0008233

[Term]
id: GO:0031369
name: translation initiation factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031370
name: eukaryotic initiation factor 4G binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah]
synonym: "eIF4G binding" EXACT []
is_a: GO:0031369 ! translation initiation factor binding

[Term]
id: GO:0031371
name: ubiquitin conjugating enzyme complex
namespace: cellular_component
def: "Any complex that possesses ubiquitin conjugating enzyme activity." [GOC:mah]
subset: goslim_pir
synonym: "E2 complex" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031372
name: UBC13-MMS2 complex
namespace: cellular_component
def: "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p." [GOC:mah, PMID:15772086]
is_a: GO:0031371 ! ubiquitin conjugating enzyme complex

[Term]
id: GO:0031373
name: cytosolic fatty acid synthase complex
namespace: cellular_component
def: "A fatty acid synthase complex located in the cytosol." [GOC:mah]
synonym: "cytosolic FAS complex" EXACT []
is_a: GO:0005835 ! fatty acid synthase complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0031374
name: cytosolic type I fatty acid synthase complex
namespace: cellular_component
def: "A cytosolic fatty acid synthase complex in which each polypeptide chain contains several different catalytic sites." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385]
synonym: "cytosolic type I FAS complex" EXACT []
is_a: GO:0031373 ! cytosolic fatty acid synthase complex

[Term]
id: GO:0031375
name: type II fatty acid synthase complex
namespace: cellular_component
def: "A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385]
synonym: "type II FAS" EXACT []
synonym: "type II FAS complex" EXACT []
synonym: "type II fatty acid synthase" EXACT []
is_a: GO:0005835 ! fatty acid synthase complex

[Term]
id: GO:0031376
name: cytosolic type II fatty acid synthase complex
namespace: cellular_component
def: "A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the cytosol." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385]
synonym: "cytosolic type II FAS complex" EXACT []
is_a: GO:0031373 ! cytosolic fatty acid synthase complex
is_a: GO:0031375 ! type II fatty acid synthase complex

[Term]
id: GO:0031377
name: mitochondrial type II fatty acid synthase complex
namespace: cellular_component
def: "A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the mitochondrion." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385]
synonym: "mitochondrial type II FAS complex" EXACT []
is_a: GO:0031375 ! type II fatty acid synthase complex
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0031378
name: plastid type II fatty acid synthase complex
namespace: cellular_component
def: "A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in a plastid." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094, PMID:12957385]
synonym: "plastid type II FAS complex" EXACT []
is_a: GO:0031375 ! type II fatty acid synthase complex
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0031379
name: RNA-directed RNA polymerase complex
namespace: cellular_component
def: "A protein complex that possesses RNA-directed RNA polymerase activity." [GOC:mah]
is_a: GO:0030880 ! RNA polymerase complex

[Term]
id: GO:0031380
name: nuclear RNA-directed RNA polymerase complex
namespace: cellular_component
def: "A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976]
synonym: "Rdr1 complex" NARROW []
synonym: "RDRC" EXACT []
is_a: GO:0031379 ! RNA-directed RNA polymerase complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0031381
name: viral RNA-directed RNA polymerase complex
namespace: cellular_component
def: "A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus." [GOC:mah, PMID:15574411, PMID:15613301]
is_a: GO:0031379 ! RNA-directed RNA polymerase complex

[Term]
id: GO:0031382
name: mating projection assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a cell projection in response to mating pheromone. This process is observed in unicellular fungi." [GOC:mah, PMID:14734532]
synonym: "mating projection biogenesis" RELATED [GOC:mah]
is_a: GO:0030031 ! cell projection assembly
relationship: part_of GO:0000753 ! cellular morphogenesis during conjugation with cellular fusion

[Term]
id: GO:0031383
name: regulation of mating projection assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mating projection formation by unicellular fungi." [PMID:14734532]
synonym: "regulation of mating projection biogenesis" RELATED [GOC:mah]
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0031137 ! regulation of conjugation with cellular fusion
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0060491 ! regulation of cell projection assembly
relationship: regulates GO:0031382 ! mating projection assembly

[Term]
id: GO:0031384
name: regulation of initiation of mating projection growth
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi." [PMID:14734532]
is_a: GO:0031383 ! regulation of mating projection assembly

[Term]
id: GO:0031385
name: regulation of termination of mating projection growth
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi." [PMID:14734532]
is_a: GO:0031383 ! regulation of mating projection assembly

[Term]
id: GO:0031386
name: protein tag
namespace: molecular_function
def: "Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question." [GOC:go_curators]
subset: goslim_generic
subset: goslim_pir
synonym: "protein tagging activity" RELATED []
synonym: "ubiquitin" RELATED []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0031387
name: MPF complex
namespace: cellular_component
def: "A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC)." [PMID:12045216]
is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex

[Term]
id: GO:0031388
name: organic acid phosphorylation
namespace: biological_process
def: "The process of introducing one or more phosphate groups into an organic acid." [GOC:mah]
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0016310 ! phosphorylation

[Term]
id: GO:0031389
name: Rad17 RFC-like complex
namespace: cellular_component
def: "A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842]
synonym: "Rad17-RFC" EXACT []
synonym: "Rad17-RLC" EXACT []
synonym: "Rad24p RFC-like complex" EXACT []
synonym: "RFC (Rad17)" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0031390
name: Ctf18 RFC-like complex
namespace: cellular_component
def: "A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p." [PMID:14614842]
synonym: "Ctf18-RFC" EXACT []
synonym: "Ctf18-RLC" EXACT []
synonym: "RFC (Ctf18)" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0031391
name: Elg1 RFC-like complex
namespace: cellular_component
def: "A pentameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842]
synonym: "Elg1-RFC" EXACT []
synonym: "Elg1-RLC" EXACT []
synonym: "RFC (Elg1)" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0031392
name: regulation of prostaglandin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah]
synonym: "regulation of prostaglandin anabolism" EXACT []
synonym: "regulation of prostaglandin biosynthesis" EXACT []
synonym: "regulation of prostaglandin formation" EXACT []
synonym: "regulation of prostaglandin synthesis" EXACT []
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
relationship: regulates GO:0001516 ! prostaglandin biosynthetic process

[Term]
id: GO:0031393
name: negative regulation of prostaglandin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah]
synonym: "down regulation of prostaglandin biosynthetic process" EXACT []
synonym: "down-regulation of prostaglandin biosynthetic process" EXACT []
synonym: "downregulation of prostaglandin biosynthetic process" EXACT []
synonym: "inhibition of prostaglandin biosynthetic process" NARROW []
synonym: "negative regulation of prostaglandin anabolism" EXACT []
synonym: "negative regulation of prostaglandin biosynthesis" EXACT []
synonym: "negative regulation of prostaglandin formation" EXACT []
synonym: "negative regulation of prostaglandin synthesis" EXACT []
is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process
is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process
relationship: negatively_regulates GO:0001516 ! prostaglandin biosynthetic process

[Term]
id: GO:0031394
name: positive regulation of prostaglandin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah]
synonym: "activation of prostaglandin biosynthetic process" NARROW []
synonym: "positive regulation of prostaglandin anabolism" EXACT []
synonym: "positive regulation of prostaglandin biosynthesis" EXACT []
synonym: "positive regulation of prostaglandin formation" EXACT []
synonym: "positive regulation of prostaglandin synthesis" EXACT []
synonym: "stimulation of prostaglandin biosynthetic process" NARROW []
synonym: "up regulation of prostaglandin biosynthetic process" EXACT []
synonym: "up-regulation of prostaglandin biosynthetic process" EXACT []
synonym: "upregulation of prostaglandin biosynthetic process" EXACT []
is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process
is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process
relationship: positively_regulates GO:0001516 ! prostaglandin biosynthetic process

[Term]
id: GO:0031395
name: bursicon neuropeptide hormone complex
namespace: cellular_component
def: "A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits." [GOC:rc]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0031396
name: regulation of protein ubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of ubiquitin moieties to a protein." [GOC:mah]
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0016567 ! protein ubiquitination

[Term]
id: GO:0031397
name: negative regulation of protein ubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the addition of ubiquitin moieties to a protein." [GOC:mah]
synonym: "down regulation of protein ubiquitination" EXACT []
synonym: "down-regulation of protein ubiquitination" EXACT []
synonym: "downregulation of protein ubiquitination" EXACT []
synonym: "inhibition of protein ubiquitination" NARROW []
is_a: GO:0031396 ! regulation of protein ubiquitination
is_a: GO:0031400 ! negative regulation of protein modification process
relationship: negatively_regulates GO:0016567 ! protein ubiquitination

[Term]
id: GO:0031398
name: positive regulation of protein ubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin moieties to a protein." [GOC:mah]
synonym: "activation of protein ubiquitination" NARROW []
synonym: "stimulation of protein ubiquitination" NARROW []
synonym: "up regulation of protein ubiquitination" EXACT []
synonym: "up-regulation of protein ubiquitination" EXACT []
synonym: "upregulation of protein ubiquitination" EXACT []
is_a: GO:0031396 ! regulation of protein ubiquitination
is_a: GO:0031401 ! positive regulation of protein modification process
relationship: positively_regulates GO:0016567 ! protein ubiquitination

[Term]
id: GO:0031399
name: regulation of protein modification process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]
subset: gosubset_prok
is_a: GO:0032268 ! regulation of cellular protein metabolic process
relationship: regulates GO:0006464 ! protein modification process

[Term]
id: GO:0031400
name: negative regulation of protein modification process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]
synonym: "down regulation of protein modification" EXACT []
synonym: "down-regulation of protein modification" EXACT []
synonym: "downregulation of protein modification" EXACT []
synonym: "inhibition of protein modification" NARROW []
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0032269 ! negative regulation of cellular protein metabolic process
relationship: negatively_regulates GO:0006464 ! protein modification process

[Term]
id: GO:0031401
name: positive regulation of protein modification process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb]
synonym: "activation of protein modification" NARROW []
synonym: "stimulation of protein modification" NARROW []
synonym: "up regulation of protein modification" EXACT []
synonym: "up-regulation of protein modification" EXACT []
synonym: "upregulation of protein modification" EXACT []
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0032270 ! positive regulation of cellular protein metabolic process
relationship: positively_regulates GO:0006464 ! protein modification process

[Term]
id: GO:0031402
name: sodium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with sodium ions (Na+)." [GOC:mah]
subset: gosubset_prok
is_a: GO:0031420 ! alkali metal ion binding

[Term]
id: GO:0031403
name: lithium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lithium ions (Li+)." [GOC:mah]
subset: gosubset_prok
is_a: GO:0031420 ! alkali metal ion binding

[Term]
id: GO:0031404
name: chloride ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with chloride ions (Cl-)." [GOC:mah]
subset: gosubset_prok
synonym: "chloride binding" EXACT []
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0031405
name: lipoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lipoic acid, 1,2-dithiolane-3-pentanoic acid." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0031406 ! carboxylic acid binding
is_a: GO:0050662 ! coenzyme binding

[Term]
id: GO:0031406
name: carboxylic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0031407
name: oxylipin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids." [GOC:mah, PMID:11960741]
subset: gosubset_prok
synonym: "oxylipin metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0031408
name: oxylipin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids." [GOC:mah, PMID:11960741]
synonym: "oxylipin anabolism" EXACT []
synonym: "oxylipin biosynthesis" EXACT []
synonym: "oxylipin formation" EXACT []
synonym: "oxylipin synthesis" EXACT []
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0031407 ! oxylipin metabolic process

[Term]
id: GO:0031409
name: pigment binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0031410
name: cytoplasmic vesicle
namespace: cellular_component
def: "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah]
subset: gosubset_prok
xref: NIF_Subcellular:sao180601769
is_a: GO:0031982 ! vesicle
is_a: GO:0043229 ! intracellular organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031411
name: gas vesicle
namespace: cellular_component
def: "A hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content aquatic microbes are able to perform vertical migrations." [PMID:8177173]
subset: gosubset_prok
is_a: GO:0031410 ! cytoplasmic vesicle
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0031412
name: gas vesicle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a gas vesicle. A gas vesicle is a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps." [GOC:mah]
synonym: "gas vesicle biosynthesis" NARROW [GOC:mah]
synonym: "gas vesicle formation" NARROW [GOC:mah]
synonym: "gas vesicle organisation" EXACT [GOC:curators]
synonym: "gas vesicle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016050 ! vesicle organization

[Term]
id: GO:0031413
name: regulation of buoyancy
namespace: biological_process
def: "Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases." [GOC:mah, PATO:0001420]
synonym: "buoyancy regulation" EXACT []
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0031414
name: N-terminal protein acetyltransferase complex
namespace: cellular_component
def: "A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule." [GOC:mah]
synonym: "NAT complex" EXACT []
is_a: GO:0031248 ! protein acetyltransferase complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031415
name: NatA complex
namespace: cellular_component
def: "A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins." [PMID:12890471]
synonym: "N-terminal acetyltransferase A complex" EXACT []
is_a: GO:0031414 ! N-terminal protein acetyltransferase complex

[Term]
id: GO:0031416
name: NatB complex
namespace: cellular_component
def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471]
synonym: "N-terminal acetyltransferase B complex" EXACT []
is_a: GO:0031414 ! N-terminal protein acetyltransferase complex

[Term]
id: GO:0031417
name: NatC complex
namespace: cellular_component
def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p." [PMID:12890471]
synonym: "N-terminal acetyltransferase C complex" EXACT []
is_a: GO:0031414 ! N-terminal protein acetyltransferase complex

[Term]
id: GO:0031418
name: L-ascorbic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [ChEBI:38290, GOC:mah]
synonym: "L-ascorbate binding" EXACT []
synonym: "vitamin C binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0031406 ! carboxylic acid binding

[Term]
id: GO:0031419
name: cobalamin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah]
synonym: "vitamin B12 binding" EXACT []
is_a: GO:0019842 ! vitamin binding
is_a: GO:0046906 ! tetrapyrrole binding

[Term]
id: GO:0031420
name: alkali metal ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen." [GOC:mah]
subset: gosubset_prok
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0031421
name: invertasome
namespace: cellular_component
def: "A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts." [PMID:11114897, PMID:9732277]
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031422
name: RecQ helicase-Topo III complex
namespace: cellular_component
def: "A complex containing a RecQ family helicase and a topoisomerase III homologue; may also include one or more additional proteins; conserved from E. coli to human." [PMID:15889139]
synonym: "Sgs1-Top3 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0031423
name: hexon binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a hexon, the major protein component of the icosahedral capsid of an adenovirus." [GOC:mah, PMID:12915569]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031424
name: keratinization
namespace: biological_process
def: "The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb]
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0030216 ! keratinocyte differentiation

[Term]
id: GO:0031425
name: chloroplast RNA processing
namespace: biological_process
def: "The conversion of a primary RNA molecule transcribed from a chloroplast genome into one or more mature RNA molecules." [GOC:mah]
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0031426
name: polycistronic mRNA processing
namespace: biological_process
def: "The conversion of a primary mRNA transcript containing more than one complete protein-coding region into individual mature mRNA molecules." [GOC:mah]
is_a: GO:0006397 ! mRNA processing

[Term]
id: GO:0031427
name: response to methotrexate
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [ChEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0014070 ! response to organic cyclic substance

[Term]
id: GO:0031428
name: box C/D snoRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex containing small nucleolar RNA of the box C/D type." [ISBN:0879695897]
is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0031429
name: box H/ACA snoRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex containing small nucleolar RNA of the box H/ACA type." [ISBN:0879695897]
is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex
is_a: GO:0044452 ! nucleolar part

[Term]
id: GO:0031430
name: M band
namespace: cellular_component
def: "The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815316194]
synonym: "M disc" EXACT []
synonym: "M line" NARROW []
synonym: "mesophragma" EXACT []
synonym: "midline" BROAD []
xref: Wikipedia:Sarcomere#bands
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0031672 ! A band

[Term]
id: GO:0031431
name: Dbf4-dependent protein kinase complex
namespace: cellular_component
def: "A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins." [PMID:12045100]
synonym: "Cdc7-Dbf4 complex" NARROW []
synonym: "DDK" EXACT []
synonym: "Hsk1-Dfp1 kinase complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031432
name: titin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively." [GOC:mah, PMID:10481174]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0031433
name: telethonin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase." [GOC:mah, PMID:10481174]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0031434
name: mitogen-activated protein kinase kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase." [GOC:mah]
synonym: "MAPKK binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0031435
name: mitogen-activated protein kinase kinase kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase." [GOC:bf]
synonym: "MAPKKK binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0031436
name: BRCA1-BARD1 complex
namespace: cellular_component
def: "A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage." [PMID:12787778]
is_a: GO:0000152 ! nuclear ubiquitin ligase complex

[Term]
id: GO:0031437
name: regulation of mRNA cleavage
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA cleavage, any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah]
is_a: GO:0050684 ! regulation of mRNA processing
relationship: regulates GO:0006379 ! mRNA cleavage

[Term]
id: GO:0031438
name: negative regulation of mRNA cleavage
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cleavage." [GOC:mah]
synonym: "down regulation of mRNA cleavage" EXACT []
synonym: "down-regulation of mRNA cleavage" EXACT []
synonym: "downregulation of mRNA cleavage" EXACT []
synonym: "inhibition of mRNA cleavage" NARROW []
is_a: GO:0031437 ! regulation of mRNA cleavage
is_a: GO:0050686 ! negative regulation of mRNA processing
relationship: negatively_regulates GO:0006379 ! mRNA cleavage

[Term]
id: GO:0031439
name: positive regulation of mRNA cleavage
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA cleavage." [GOC:mah]
synonym: "activation of mRNA cleavage" NARROW []
synonym: "stimulation of mRNA cleavage" NARROW []
synonym: "up regulation of mRNA cleavage" EXACT []
synonym: "up-regulation of mRNA cleavage" EXACT []
synonym: "upregulation of mRNA cleavage" EXACT []
is_a: GO:0031437 ! regulation of mRNA cleavage
is_a: GO:0050685 ! positive regulation of mRNA processing
relationship: positively_regulates GO:0006379 ! mRNA cleavage

[Term]
id: GO:0031440
name: regulation of mRNA 3'-end processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah]
is_a: GO:0050684 ! regulation of mRNA processing
relationship: regulates GO:0031124 ! mRNA 3'-end processing

[Term]
id: GO:0031441
name: negative regulation of mRNA 3'-end processing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah]
synonym: "down regulation of mRNA 3'-end processing" EXACT []
synonym: "down-regulation of mRNA 3'-end processing" EXACT []
synonym: "downregulation of mRNA 3'-end processing" EXACT []
synonym: "inhibition of mRNA 3'-end processing" NARROW []
is_a: GO:0031440 ! regulation of mRNA 3'-end processing
is_a: GO:0050686 ! negative regulation of mRNA processing
relationship: negatively_regulates GO:0031124 ! mRNA 3'-end processing

[Term]
id: GO:0031442
name: positive regulation of mRNA 3'-end processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah]
synonym: "activation of mRNA 3'-end processing" NARROW []
synonym: "stimulation of mRNA 3'-end processing" NARROW []
synonym: "up regulation of mRNA 3'-end processing" EXACT []
synonym: "up-regulation of mRNA 3'-end processing" EXACT []
synonym: "upregulation of mRNA 3'-end processing" EXACT []
is_a: GO:0031440 ! regulation of mRNA 3'-end processing
is_a: GO:0050685 ! positive regulation of mRNA processing
relationship: positively_regulates GO:0031124 ! mRNA 3'-end processing

[Term]
id: GO:0031443
name: fast-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "A process whereby force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability." [GOC:ef, GOC:mah, GOC:mtg_muscle]
synonym: "fast-twitch skeletal fiber contraction" EXACT []
synonym: "fast-twitch skeletal fibre contraction" EXACT []
synonym: "fast-twitch skeletal muscle fibre contraction" EXACT []
synonym: "fast-twitch skeletal myofiber contraction" EXACT []
synonym: "fast-twitch skeletal myofibre contraction" EXACT []
is_a: GO:0014721 ! twitch skeletal muscle contraction

[Term]
id: GO:0031444
name: slow-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "A process whereby force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue." [GOC:ef, GOC:mah, GOC:mtg_muscle]
synonym: "slow-twitch skeletal muscle fibre contraction" EXACT []
is_a: GO:0014721 ! twitch skeletal muscle contraction

[Term]
id: GO:0031445
name: regulation of heterochromatin formation
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent or location of heterochromatin formation." [GOC:mah]
is_a: GO:0010847 ! regulation of chromatin assembly
relationship: regulates GO:0031507 ! heterochromatin formation

[Term]
id: GO:0031446
name: regulation of fast-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0014724 ! regulation of twitch skeletal muscle contraction
relationship: regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031447
name: negative regulation of fast-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "down regulation of fast-twitch skeletal muscle contraction" EXACT []
synonym: "down-regulation of fast-twitch skeletal muscle contraction" EXACT []
synonym: "downregulation of fast-twitch skeletal muscle contraction" EXACT []
synonym: "inhibition of fast-twitch skeletal muscle contraction" NARROW []
synonym: "negative regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031446 ! regulation of fast-twitch skeletal muscle fiber contraction
is_a: GO:0045988 ! negative regulation of striated muscle contraction
relationship: negatively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031448
name: positive regulation of fast-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "activation of fast-twitch skeletal muscle contraction" NARROW []
synonym: "positive regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of fast-twitch skeletal muscle contraction" NARROW []
synonym: "up regulation of fast-twitch skeletal muscle contraction" EXACT []
synonym: "up-regulation of fast-twitch skeletal muscle contraction" EXACT []
synonym: "upregulation of fast-twitch skeletal muscle contraction" EXACT []
is_a: GO:0031446 ! regulation of fast-twitch skeletal muscle fiber contraction
is_a: GO:0045989 ! positive regulation of striated muscle contraction
relationship: positively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031449
name: regulation of slow-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0014724 ! regulation of twitch skeletal muscle contraction
relationship: regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031450
name: negative regulation of slow-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "down regulation of slow-twitch skeletal muscle contraction" EXACT []
synonym: "down-regulation of slow-twitch skeletal muscle contraction" EXACT []
synonym: "downregulation of slow-twitch skeletal muscle contraction" EXACT []
synonym: "inhibition of slow-twitch skeletal muscle contraction" NARROW []
synonym: "negative regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031449 ! regulation of slow-twitch skeletal muscle fiber contraction
is_a: GO:0045988 ! negative regulation of striated muscle contraction
relationship: negatively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031451
name: positive regulation of slow-twitch skeletal muscle fiber contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb]
synonym: "activation of slow-twitch skeletal muscle contraction" NARROW []
synonym: "positive regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of slow-twitch skeletal muscle contraction" NARROW []
synonym: "up regulation of slow-twitch skeletal muscle contraction" EXACT []
synonym: "up-regulation of slow-twitch skeletal muscle contraction" EXACT []
synonym: "upregulation of slow-twitch skeletal muscle contraction" EXACT []
is_a: GO:0031449 ! regulation of slow-twitch skeletal muscle fiber contraction
is_a: GO:0045989 ! positive regulation of striated muscle contraction
relationship: positively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction

[Term]
id: GO:0031452
name: negative regulation of heterochromatin formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heterochromatin formation." [GOC:mah]
synonym: "down regulation of heterochromatin formation" EXACT []
synonym: "down-regulation of heterochromatin formation" EXACT []
synonym: "downregulation of heterochromatin formation" EXACT []
synonym: "inhibition of heterochromatin formation" NARROW []
is_a: GO:0031445 ! regulation of heterochromatin formation
is_a: GO:0045798 ! negative regulation of chromatin assembly or disassembly
relationship: negatively_regulates GO:0031507 ! heterochromatin formation

[Term]
id: GO:0031453
name: positive regulation of heterochromatin formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heterochromatin formation." [GOC:mah]
synonym: "activation of heterochromatin formation" NARROW []
synonym: "stimulation of heterochromatin formation" NARROW []
synonym: "up regulation of heterochromatin formation" EXACT []
synonym: "up-regulation of heterochromatin formation" EXACT []
synonym: "upregulation of heterochromatin formation" EXACT []
is_a: GO:0031445 ! regulation of heterochromatin formation
is_a: GO:0045799 ! positive regulation of chromatin assembly or disassembly
relationship: positively_regulates GO:0031507 ! heterochromatin formation

[Term]
id: GO:0031454
name: regulation of extent of heterochromatin formation
namespace: biological_process
def: "Any process that modulates the extent or location of heterochromatin formation." [GOC:mah]
synonym: "regulation of heterochromatin spreading" RELATED []
is_a: GO:0031445 ! regulation of heterochromatin formation

[Term]
id: GO:0031455
name: glycine betaine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycine betaine, N-trimethylglycine." [GOC:mah]
subset: gosubset_prok
synonym: "glycine betaine metabolism" EXACT []
synonym: "N-trimethylglycine metabolic process" EXACT []
synonym: "N-trimethylglycine metabolism" EXACT []
is_a: GO:0006577 ! betaine metabolic process

[Term]
id: GO:0031456
name: glycine betaine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycine betaine, N-trimethylglycine." [GOC:mah]
subset: gosubset_prok
synonym: "glycine betaine anabolism" EXACT []
synonym: "glycine betaine biosynthesis" EXACT []
synonym: "glycine betaine formation" EXACT []
synonym: "glycine betaine synthesis" EXACT []
synonym: "N-trimethylglycine biosynthesis" EXACT []
synonym: "N-trimethylglycine biosynthetic process" EXACT []
is_a: GO:0006578 ! betaine biosynthetic process
is_a: GO:0031455 ! glycine betaine metabolic process

[Term]
id: GO:0031457
name: glycine betaine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine." [GOC:mah]
synonym: "glycine betaine breakdown" EXACT []
synonym: "glycine betaine catabolism" EXACT []
synonym: "glycine betaine degradation" EXACT []
synonym: "N-trimethylglycine catabolic process" EXACT []
synonym: "N-trimethylglycine catabolism" EXACT []
is_a: GO:0006579 ! betaine catabolic process
is_a: GO:0031455 ! glycine betaine metabolic process

[Term]
id: GO:0031458
name: betaine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in)." [GOC:mlg]
synonym: "betaine ABC transporter" NARROW []
is_a: GO:0015199 ! betaine transmembrane transporter activity
is_a: GO:0031263 ! amine-transporting ATPase activity

[Term]
id: GO:0031459
name: glycine betaine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in)." [GOC:mlg]
synonym: "glycine betaine ABC transporter" NARROW []
synonym: "N-trimethylglycine-transporting ATPase activity" EXACT []
is_a: GO:0031458 ! betaine-transporting ATPase activity

[Term]
id: GO:0031460
name: glycine betaine transport
namespace: biological_process
def: "The directed movement of glycine betaine, N-trimethylglycine, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "N-trimethylglycine transport" EXACT []
is_a: GO:0006865 ! amino acid transport
is_a: GO:0015838 ! betaine transport

[Term]
id: GO:0031461
name: cullin-RING ubiquitin ligase complex
namespace: cellular_component
def: "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063]
synonym: "CRL complex" EXACT []
synonym: "cullin complex" EXACT []
synonym: "cullin-RING ligase" RELATED []
is_a: GO:0000151 ! ubiquitin ligase complex

[Term]
id: GO:0031462
name: Cul2-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]
synonym: "CBC complex" BROAD []
synonym: "CDL2 complex" EXACT []
synonym: "CRL2 complex" EXACT []
synonym: "cullin-RING ligase 2" EXACT []
synonym: "EC2S complex" BROAD []
synonym: "ECS complex" BROAD []
synonym: "SCF2 complex" RELATED []
synonym: "VBC complex" NARROW []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031463
name: Cul3-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063]
synonym: "BC3B complex" EXACT []
synonym: "BCR3 complex" EXACT []
synonym: "CDL3 complex" EXACT []
synonym: "CRL3 complex" EXACT []
synonym: "cullin-RING ligase 3" EXACT []
synonym: "SCF3 complex" RELATED []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031464
name: Cul4A-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063]
synonym: "CDL4 complex" EXACT []
synonym: "CRL4 complex" EXACT []
synonym: "cullin-RING ligase 4A" EXACT []
synonym: "DCX complex" EXACT []
synonym: "SCF4 complex" RELATED []
synonym: "VDC complex" NARROW []
is_a: GO:0080008 ! CUL4 RING ubiquitin ligase complex

[Term]
id: GO:0031465
name: Cul4B-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits." [PMID:15571813, PMID:15688063]
synonym: "cullin-RING ligase 4B" EXACT []
is_a: GO:0080008 ! CUL4 RING ubiquitin ligase complex

[Term]
id: GO:0031466
name: Cul5-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063]
synonym: "CDL5 complex" EXACT []
synonym: "CRL5 complex" EXACT []
synonym: "cullin-RING ligase 5" EXACT []
synonym: "EC2S complex" BROAD []
synonym: "SCF5 complex" RELATED []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031467
name: Cul7-RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein." [PMID:15571813, PMID:15688063]
synonym: "CDL7 complex" EXACT []
synonym: "CRL7 complex" EXACT []
synonym: "cullin-RING ligase 7" EXACT []
synonym: "SCF7 complex" EXACT []
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0031468
name: nuclear envelope reassembly
namespace: biological_process
def: "The reformation of the nuclear envelope following its breakdown in the context of a normal process." [GOC:mah]
is_a: GO:0006998 ! nuclear envelope organization

[Term]
id: GO:0031469
name: polyhedral organelle
namespace: cellular_component
def: "An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0031470
name: carboxysome
namespace: cellular_component
def: "An organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide including mechanisms for the concentration of carbonate to increase the efficiency of fixation under low-carbon dioxide conditions." [GOC:js, PMID:8157606, PMID:8491708]
subset: gosubset_prok
xref: Wikipedia:Carboxysome
is_a: GO:0031469 ! polyhedral organelle

[Term]
id: GO:0031471
name: ethanolamine degradation polyhedral organelle
namespace: cellular_component
def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase." [GOC:js, PMID:11844753]
subset: gosubset_prok
synonym: "ethanolamine metabolosome" RELATED []
is_a: GO:0031469 ! polyhedral organelle

[Term]
id: GO:0031472
name: propanediol degradation polyhedral organelle
namespace: cellular_component
def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081]
subset: gosubset_prok
is_a: GO:0031469 ! polyhedral organelle

[Term]
id: GO:0031473
name: myosin III binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a class III myosin; myosin III is monomeric and has an N terminal kinase domain." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0031474
name: myosin IV complex
namespace: cellular_component
def: "A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031475
name: myosin V complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031476
name: myosin VI complex
namespace: cellular_component
def: "A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031477
name: myosin VII complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031478
name: myosin VIII complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031479
name: myosin IX complex
namespace: cellular_component
def: "A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031480
name: myosin X complex
namespace: cellular_component
def: "A myosin complex containing one or more class X myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031481
name: myosin XI complex
namespace: cellular_component
def: "A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031482
name: myosin XII complex
namespace: cellular_component
def: "A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031483
name: myosin XIII complex
namespace: cellular_component
def: "A myosin complex containing one or more class XIII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031484
name: myosin XIV complex
namespace: cellular_component
def: "A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031485
name: myosin XV complex
namespace: cellular_component
def: "A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031486
name: myosin XVI complex
namespace: cellular_component
def: "A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:11294886]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031487
name: myosin XVII complex
namespace: cellular_component
def: "A myosin complex containing one or more class XVII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031488
name: myosin XVIII complex
namespace: cellular_component
def: "A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain." [PMID:11294886]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0031489
name: myosin V binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0031490
name: chromatin DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA that is assembled into chromatin." [GOC:mah]
is_a: GO:0003682 ! chromatin binding
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0031491
name: nucleosome binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah]
is_a: GO:0003682 ! chromatin binding

[Term]
id: GO:0031492
name: nucleosomal DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the DNA portion of a nucleosome." [GOC:mah]
is_a: GO:0031490 ! chromatin DNA binding
is_a: GO:0031491 ! nucleosome binding

[Term]
id: GO:0031493
name: nucleosomal histone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a histone that is assembled into a nucleosome." [GOC:mah]
is_a: GO:0031491 ! nucleosome binding
is_a: GO:0042393 ! histone binding

[Term]
id: GO:0031494
name: regulation of mating type switching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mating type switching, the conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [GOC:mah]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0007533 ! mating type switching

[Term]
id: GO:0031495
name: negative regulation of mating type switching
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mating type switching." [GOC:mah]
synonym: "down regulation of mating type switching" EXACT []
synonym: "down-regulation of mating type switching" EXACT []
synonym: "downregulation of mating type switching" EXACT []
synonym: "inhibition of mating type switching" NARROW []
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0031494 ! regulation of mating type switching
is_a: GO:0051053 ! negative regulation of DNA metabolic process
relationship: negatively_regulates GO:0007533 ! mating type switching

[Term]
id: GO:0031496
name: positive regulation of mating type switching
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mating type switching." [GOC:mah]
synonym: "activation of mating type switching" NARROW []
synonym: "stimulation of mating type switching" NARROW []
synonym: "up regulation of mating type switching" EXACT []
synonym: "up-regulation of mating type switching" EXACT []
synonym: "upregulation of mating type switching" EXACT []
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:0031494 ! regulation of mating type switching
is_a: GO:0051054 ! positive regulation of DNA metabolic process
relationship: positively_regulates GO:0007533 ! mating type switching

[Term]
id: GO:0031497
name: chromatin assembly
namespace: biological_process
def: "The assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html]
synonym: "establishment of chromatin architecture" EXACT [GOC:mah]
is_a: GO:0006333 ! chromatin assembly or disassembly
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0006323 ! DNA packaging

[Term]
id: GO:0031498
name: chromatin disassembly
namespace: biological_process
def: "The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, and other proteins." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html]
is_a: GO:0006333 ! chromatin assembly or disassembly
is_a: GO:0022411 ! cellular component disassembly

[Term]
id: GO:0031499
name: TRAMP complex
namespace: cellular_component
def: "A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control." [PMID:15173578, PMID:15828860, PMID:15935758, PMID:15935759, PMID:16373491, PMID:16374505, PMID:16431988, PMID:16973437, PMID:17410208, PMID:17652137]
synonym: "TRAMP4 complex" NARROW []
synonym: "TRAMP5 complex" NARROW []
synonym: "Trf4 complex" NARROW []
synonym: "Trf4 poly(A) polymerase complex" NARROW []
synonym: "Trf4p-Air2p-Mtr4p polyadenylation complex" NARROW []
xref: Wikipedia:TRAMP_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0031500
name: Tea1 cell-end complex
namespace: cellular_component
def: "A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity." [PMID:15936270]
is_a: GO:0005875 ! microtubule associated complex
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0000133 ! polarisome

[Term]
id: GO:0031501
name: mannosyltransferase complex
namespace: cellular_component
def: "A complex that posseses mannosyltransferase activity." [GOC:mah]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031502
name: dolichyl-phosphate-mannose-protein mannosyltransferase complex
namespace: cellular_component
def: "A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies." [GOC:mah, PMID:15948957]
synonym: "PMT family mannosyltransferase complex" RELATED []
synonym: "protein O-mannosyltransferase complex" EXACT []
is_a: GO:0031501 ! mannosyltransferase complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0031503
name: protein complex localization
namespace: biological_process
def: "Any process by which a protein complex is transported to, or maintained in, a specific location." [GOC:mah]
subset: gosubset_prok
synonym: "establishment and maintenance of protein complex localization" EXACT []
is_a: GO:0051179 ! localization

[Term]
id: GO:0031504
name: peptidoglycan-based cell wall organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the peptidoglycan-based cell wall." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "peptidoglycan-based cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007047 ! cellular cell wall organization

[Term]
id: GO:0031505
name: fungal-type cell wall organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu]
synonym: "beta-glucan-containing cell wall organization and biogenesis" RELATED []
synonym: "chitin- and beta-glucan-containing cell wall organisation" NARROW []
synonym: "chitin- and beta-glucan-containing cell wall organization and biogenesis" NARROW []
synonym: "chitin-containing cell wall organization and biogenesis" RELATED []
synonym: "fungal-type cell wall organization and biogenesis" RELATED []
is_a: GO:0007047 ! cellular cell wall organization

[Term]
id: GO:0031506
name: cell wall glycoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cell wall glycoproteins, any cell wall protein that contains covalently bound sugar residues other than as a moiety of nucleic acid." [GOC:mah]
subset: gosubset_prok
synonym: "cell wall glycoprotein anabolism" EXACT []
synonym: "cell wall glycoprotein biosynthesis" EXACT []
synonym: "cell wall glycoprotein formation" EXACT []
synonym: "cell wall glycoprotein synthesis" EXACT []
is_a: GO:0009101 ! glycoprotein biosynthetic process
is_a: GO:0044038 ! cell wall macromolecule biosynthetic process

[Term]
id: GO:0031507
name: heterochromatin formation
namespace: biological_process
def: "The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent." [GOC:mah]
synonym: "establishment of heterochromatin architecture" EXACT [GOC:mah]
synonym: "heterochromatin assembly" EXACT []
is_a: GO:0006338 ! chromatin remodeling
is_a: GO:0031497 ! chromatin assembly
is_a: GO:0070828 ! heterochromatin organization

[Term]
id: GO:0031508
name: centromeric heterochromatin assembly
namespace: biological_process
def: "The assembly of chromatin into heterochromatin near the centromere." [GOC:mah]
synonym: "centric heterochromatin formation" RELATED []
synonym: "centromeric heterochromatin assembly" EXACT []
synonym: "centromeric heterochromatin biosynthesis" EXACT []
is_a: GO:0031055 ! chromatin remodeling at centromere
is_a: GO:0031507 ! heterochromatin formation
relationship: part_of GO:0034508 ! centromere complex assembly

[Term]
id: GO:0031509
name: telomeric heterochromatin formation
namespace: biological_process
def: "The assembly of chromatin into heterochromatin at the telomere." [GOC:mah]
synonym: "telomeric heterochromatin assembly" EXACT []
is_a: GO:0031507 ! heterochromatin formation

[Term]
id: GO:0031510
name: SUMO activating enzyme complex
namespace: cellular_component
def: "A conserved heterodimeric complex with SUMO activating enzyme activity." [PMID:15601841]
synonym: "SAE" EXACT []
synonym: "SUMO E1 activator enzyme complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0031511
name: Mis6-Sim4 complex
namespace: cellular_component
def: "A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human." [GOC:vw, PMID:12719471, PMID:15897182]
synonym: "Mis6 centromere subcomplex" NARROW []
synonym: "Sim4 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000939 ! inner kinetochore of condensed chromosome

[Term]
id: GO:0031512
name: motile primary cilium
namespace: cellular_component
def: "A specialized primary cilium that contains a 9 + 0 arrangement of microtubules, radial spokes, and a dynein apparatus, but no inner doublet microtubules. Motile primary cilia display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface." [GOC:kmv]
is_a: GO:0005929 ! cilium

[Term]
id: GO:0031513
name: nonmotile primary cilium
namespace: cellular_component
def: "An immotile primary cilium that may be missing the central pair of microtubules, or the central pair of microtubules and outer dynein arms. Some primary cilia also have altered arrangements of outer microtubules (fewer than nine and/or not always present as doublets). Nonmotile primary cilia typically function as sensory organelles that concentrate and organize sensory signaling molecules." [GOC:kna]
is_a: GO:0005929 ! cilium

[Term]
id: GO:0031514
name: motile secondary cilium
namespace: cellular_component
def: "A cilium that consists of a 9 + 2 arrangement of microtubules, radial spokes, and a dynein apparatus. Motile cilia, found on cells that line the lumenal ducts of various tissues, beat with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface." [GOC:kmv]
is_a: GO:0005929 ! cilium

[Term]
id: GO:0031515
name: tRNA (m1A) methyltransferase complex
namespace: cellular_component
def: "A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer." [PMID:10779558, PMID:14739239]
subset: gosubset_prok
is_a: GO:0043527 ! tRNA methyltransferase complex

[Term]
id: GO:0031516
name: far-red light photoreceptor activity
namespace: molecular_function
def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation." [GOC:nln]
is_a: GO:0009883 ! red or far-red light photoreceptor activity

[Term]
id: GO:0031517
name: red light photoreceptor activity
namespace: molecular_function
def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation." [GOC:nln]
is_a: GO:0009883 ! red or far-red light photoreceptor activity

[Term]
id: GO:0031518
name: CBF3 complex
namespace: cellular_component
def: "A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p." [PMID:13679521, PMID:9407032]
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000775 ! chromosome, centromeric region

[Term]
id: GO:0031519
name: PcG protein complex
namespace: cellular_component
def: "A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908]
subset: goslim_pir
synonym: "Polycomb Group protein complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0031520
name: plasma membrane of cell tip
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the cell tip." [GOC:mah]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0051286 ! cell tip

[Term]
id: GO:0031521
name: spitzenkorper
namespace: cellular_component
def: "Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments." [PMID:15701784, PMID:15976451]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part
relationship: part_of GO:0001411 ! hyphal tip

[Term]
id: GO:0031522
name: cell envelope Sec protein transport complex
namespace: cellular_component
def: "A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC." [GOC:mtg_sensu, PMID:15223057]
comment: Note that this term represents the protein complex involved in transport of proteins across the cytoplasmic membrane. For proteins involved in bacterial Type II secretion across the outer membrane, consider annotating to 'type II protein secretion complex ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'endoplasmic reticulum Sec complex ; GO:0031205'.
subset: gosubset_prok
synonym: "plasma membrane Sec complex" RELATED []
synonym: "Sec complex" BROAD []
synonym: "Sec secretion complex" NARROW []
synonym: "Sec translocation complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031523
name: Myb complex
namespace: cellular_component
def: "A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624]
synonym: "Myeloblastosis proto-oncogene protein complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0031524
name: menthol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah]
subset: gosubset_prok
synonym: "menthol metabolism" EXACT []
is_a: GO:0043692 ! monoterpene metabolic process

[Term]
id: GO:0031525
name: menthol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah]
subset: gosubset_prok
synonym: "menthol anabolism" EXACT []
synonym: "menthol biosynthesis" EXACT []
synonym: "menthol formation" EXACT []
synonym: "menthol synthesis" EXACT []
is_a: GO:0031524 ! menthol metabolic process
is_a: GO:0043693 ! monoterpene biosynthetic process

[Term]
id: GO:0031526
name: brush border membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the brush border." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0005903 ! brush border

[Term]
id: GO:0031527
name: filopodium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a filopodium." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0030175 ! filopodium

[Term]
id: GO:0031528
name: microvillus membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a microvillus." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0005902 ! microvillus

[Term]
id: GO:0031529
name: ruffle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell." [GOC:mah, PMID:10036235]
synonym: "ruffle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0031530
name: gonadotropin-releasing hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor for gonadotropin-releasing hormone, a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary." [PMID:15196882]
is_a: GO:0051428 ! peptide hormone receptor binding

[Term]
id: GO:0031531
name: thyrotropin-releasing hormone receptor binding
namespace: molecular_function
alt_id: GO:0031888
def: "Interacting selectively and non-covalently with a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary." [PMID:8592728]
synonym: "thyrotropin-releasing hormone receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding
is_a: GO:0051428 ! peptide hormone receptor binding

[Term]
id: GO:0031532
name: actin cytoskeleton reorganization
namespace: biological_process
alt_id: GO:0007012
def: "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah]
synonym: "actin cytoskeleton remodeling" EXACT []
synonym: "actin cytoskeleton reorganisation" EXACT [GOC:curators]
is_a: GO:0030036 ! actin cytoskeleton organization

[Term]
id: GO:0031533
name: mRNA cap methyltransferase complex
namespace: cellular_component
def: "A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping." [GOC:vw, PMID:10347220]
synonym: "mRNA (guanine-N7) methyltransferase complex" EXACT []
synonym: "mRNA capping enzyme complex" EXACT [GOC:vw]
is_a: GO:0034708 ! methyltransferase complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0031534
name: minus-end directed microtubule sliding
namespace: biological_process
def: "The movement of one microtubule along another microtubule, where the motion is directed towards the minus ends of the microtubules." [GOC:mah, GOC:vw]
is_a: GO:0051012 ! microtubule sliding

[Term]
id: GO:0031535
name: plus-end directed microtubule sliding
namespace: biological_process
def: "The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules." [GOC:mah, GOC:vw]
is_a: GO:0051012 ! microtubule sliding

[Term]
id: GO:0031536
name: positive regulation of exit from mitosis
namespace: biological_process
def: "Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:mah]
synonym: "activation of exit from mitosis" NARROW []
synonym: "stimulation of exit from mitosis" NARROW []
synonym: "up regulation of exit from mitosis" EXACT []
synonym: "up-regulation of exit from mitosis" EXACT []
synonym: "upregulation of exit from mitosis" EXACT []
is_a: GO:0007096 ! regulation of exit from mitosis
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0010458 ! exit from mitosis

[Term]
id: GO:0031537
name: regulation of anthocyanin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah]
synonym: "regulation of anthocyanin metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0043455 ! regulation of secondary metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0046283 ! anthocyanin metabolic process

[Term]
id: GO:0031538
name: negative regulation of anthocyanin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah]
synonym: "down regulation of anthocyanin metabolic process" EXACT []
synonym: "down-regulation of anthocyanin metabolic process" EXACT []
synonym: "downregulation of anthocyanin metabolic process" EXACT []
synonym: "inhibition of anthocyanin metabolic process" NARROW []
synonym: "negative regulation of anthocyanin metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0031537 ! regulation of anthocyanin metabolic process
relationship: negatively_regulates GO:0046283 ! anthocyanin metabolic process

[Term]
id: GO:0031539
name: positive regulation of anthocyanin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah]
synonym: "activation of anthocyanin metabolic process" NARROW []
synonym: "positive regulation of anthocyanin metabolism" EXACT []
synonym: "stimulation of anthocyanin metabolic process" NARROW []
synonym: "up regulation of anthocyanin metabolic process" EXACT []
synonym: "up-regulation of anthocyanin metabolic process" EXACT []
synonym: "upregulation of anthocyanin metabolic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0031537 ! regulation of anthocyanin metabolic process
relationship: positively_regulates GO:0046283 ! anthocyanin metabolic process

[Term]
id: GO:0031540
name: regulation of anthocyanin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah]
synonym: "regulation of anthocyanin anabolism" EXACT []
synonym: "regulation of anthocyanin biosynthesis" EXACT []
synonym: "regulation of anthocyanin formation" EXACT []
synonym: "regulation of anthocyanin synthesis" EXACT []
is_a: GO:0009962 ! regulation of flavonoid biosynthetic process
is_a: GO:0031537 ! regulation of anthocyanin metabolic process
relationship: regulates GO:0009718 ! anthocyanin biosynthetic process

[Term]
id: GO:0031541
name: negative regulation of anthocyanin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah]
synonym: "down regulation of anthocyanin biosynthetic process" EXACT []
synonym: "down-regulation of anthocyanin biosynthetic process" EXACT []
synonym: "downregulation of anthocyanin biosynthetic process" EXACT []
synonym: "inhibition of anthocyanin biosynthetic process" NARROW []
synonym: "negative regulation of anthocyanin anabolism" EXACT []
synonym: "negative regulation of anthocyanin biosynthesis" EXACT []
synonym: "negative regulation of anthocyanin formation" EXACT []
synonym: "negative regulation of anthocyanin synthesis" EXACT []
is_a: GO:0009964 ! negative regulation of flavonoid biosynthetic process
is_a: GO:0031538 ! negative regulation of anthocyanin metabolic process
is_a: GO:0031540 ! regulation of anthocyanin biosynthetic process
relationship: negatively_regulates GO:0009718 ! anthocyanin biosynthetic process

[Term]
id: GO:0031542
name: positive regulation of anthocyanin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah]
synonym: "activation of anthocyanin biosynthetic process" NARROW []
synonym: "positive regulation of anthocyanin anabolism" EXACT []
synonym: "positive regulation of anthocyanin biosynthesis" EXACT []
synonym: "positive regulation of anthocyanin formation" EXACT []
synonym: "positive regulation of anthocyanin synthesis" EXACT []
synonym: "stimulation of anthocyanin biosynthetic process" NARROW []
synonym: "up regulation of anthocyanin biosynthetic process" EXACT []
synonym: "up-regulation of anthocyanin biosynthetic process" EXACT []
synonym: "upregulation of anthocyanin biosynthetic process" EXACT []
is_a: GO:0009963 ! positive regulation of flavonoid biosynthetic process
is_a: GO:0031539 ! positive regulation of anthocyanin metabolic process
is_a: GO:0031540 ! regulation of anthocyanin biosynthetic process
relationship: positively_regulates GO:0009718 ! anthocyanin biosynthetic process

[Term]
id: GO:0031543
name: peptidyl-proline dioxygenase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a protein." [GOC:mah]
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0031544
name: peptidyl-proline 3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2." [GOC:mah]
is_a: GO:0031543 ! peptidyl-proline dioxygenase activity

[Term]
id: GO:0031545
name: peptidyl-proline 4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [GOC:mah]
synonym: "HIF-type prolyl 4-hydroxylase" NARROW []
synonym: "prolyl 4-hydroxylase" BROAD []
is_a: GO:0031543 ! peptidyl-proline dioxygenase activity

[Term]
id: GO:0031546
name: brain-derived neurotrophic factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the brain-derived neurotrophic factor receptor." [GOC:mah]
synonym: "BDNF receptor binding" EXACT []
synonym: "brain-derived neurotrophic factor ligand" NARROW []
is_a: GO:0005165 ! neurotrophin receptor binding

[Term]
id: GO:0031547
name: brain-derived neurotrophic factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "BDNF receptor signaling pathway" EXACT []
synonym: "BDNF signalling pathway" EXACT []
synonym: "brain-derived neurotrophic factor receptor signalling pathway" EXACT []
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0031548
name: regulation of brain-derived neurotrophic factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah]
synonym: "regulation of BDNF receptor signaling pathway" EXACT []
synonym: "regulation of BDNF receptor signalling pathway" EXACT []
synonym: "regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway

[Term]
id: GO:0031549
name: negative regulation of brain-derived neurotrophic factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah]
synonym: "down regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
synonym: "down-regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
synonym: "downregulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
synonym: "inhibition of brain-derived neurotrophic factor receptor signaling pathway" NARROW []
synonym: "negative regulation of BDNF receptor signaling pathway" EXACT []
synonym: "negative regulation of BDNF receptor signalling pathway" EXACT []
synonym: "negative regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway
relationship: negatively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway

[Term]
id: GO:0031550
name: positive regulation of brain-derived neurotrophic factor receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah]
synonym: "activation of brain-derived neurotrophic factor receptor signaling pathway" NARROW []
synonym: "positive regulation of BDNF receptor signaling pathway" EXACT []
synonym: "positive regulation of BDNF receptor signalling pathway" EXACT []
synonym: "positive regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT []
synonym: "stimulation of brain-derived neurotrophic factor receptor signaling pathway" NARROW []
synonym: "up regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
synonym: "up-regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
synonym: "upregulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway
relationship: positively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway

[Term]
id: GO:0031551
name: regulation of brain-derived neurotrophic factor receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor receptor activity." [GOC:mah]
synonym: "regulation of BDNF receptor activity" EXACT []
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway
is_a: GO:0043393 ! regulation of protein binding
is_a: GO:0045859 ! regulation of protein kinase activity

[Term]
id: GO:0031552
name: negative regulation of brain-derived neurotrophic factor receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of brain-derived neurotrophic factor receptor activity." [GOC:mah]
synonym: "down regulation of brain-derived neurotrophic factor receptor activity" EXACT []
synonym: "down-regulation of brain-derived neurotrophic factor receptor activity" EXACT []
synonym: "downregulation of brain-derived neurotrophic factor receptor activity" EXACT []
synonym: "inhibition of brain-derived neurotrophic factor receptor activity" NARROW []
synonym: "negative regulation of BDNF receptor activity" EXACT []
is_a: GO:0006469 ! negative regulation of protein kinase activity
is_a: GO:0031549 ! negative regulation of brain-derived neurotrophic factor receptor signaling pathway
is_a: GO:0031551 ! regulation of brain-derived neurotrophic factor receptor activity
is_a: GO:0032091 ! negative regulation of protein binding

[Term]
id: GO:0031553
name: positive regulation of brain-derived neurotrophic factor receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor receptor activity." [GOC:mah]
synonym: "activation of brain-derived neurotrophic factor receptor activity" NARROW []
synonym: "positive regulation of BDNF receptor activity" EXACT []
synonym: "stimulation of brain-derived neurotrophic factor receptor activity" NARROW []
synonym: "up regulation of brain-derived neurotrophic factor receptor activity" EXACT []
synonym: "up-regulation of brain-derived neurotrophic factor receptor activity" EXACT []
synonym: "upregulation of brain-derived neurotrophic factor receptor activity" EXACT []
is_a: GO:0031550 ! positive regulation of brain-derived neurotrophic factor receptor signaling pathway
is_a: GO:0031551 ! regulation of brain-derived neurotrophic factor receptor activity
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:0045860 ! positive regulation of protein kinase activity

[Term]
id: GO:0031554
name: regulation of transcription termination
namespace: biological_process
def: "Any process that modulates the frequency, rate, extent, or location of transcription termination. Transcription termination is the process by which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:mlg]
is_a: GO:0006355 ! regulation of transcription, DNA-dependent
is_a: GO:0043244 ! regulation of protein complex disassembly
relationship: regulates GO:0006353 ! transcription termination

[Term]
id: GO:0031555
name: transcriptional attenuation
namespace: biological_process
def: "Regulation of transcription through variation in where transcription termination occurs." [GOC:dh, GOC:mlg, ISBN:0198542682]
xref: Wikipedia:Attenuator_(genetics)
is_a: GO:0031554 ! regulation of transcription termination

[Term]
id: GO:0031556
name: transcriptional attenuation by ribosome
namespace: biological_process
def: "A type of transcriptional regulation at the level of early termination. This process can occur only in prokaryotes, where transcription of an operon into messenger RNA and translation of that mRNA into polypeptides occur simultaneously. The general principle is that alternative mRNA secondary structures occur under different physiological conditions such as available amount of a particular amino acid. One set of conditions favors early termination of transcription. In the classic example of the trp biosynthesis operon, translation of the gene for a short, trp-containing polypeptide called the trp operon leader peptide pauses either at a trp codon (if tryptophan is scarce) or the stop codon (if trp is readily available). In the former situation transcription continues, but in the latter a Rho-independent terminator forms and reduces, or attenuates, expression of the tryptophan biosynthesis genes. Although the polypeptides encoded by leader peptide genes appear not to be stable once their translation is complete, it is suggested by recent studies that their nascent polypeptide chains interact specifically with ribosomes, specific uncharged tRNAs, or other cellular components to inhibit release at the stop codon and improve the function of transcriptional attenuation as a regulatory switch." [GOC:dh, GOC:mlg, ISBN:0198542682]
synonym: "ribosome-mediated transcriptional " EXACT [GOC:dph, GOC:tb]
is_a: GO:0031555 ! transcriptional attenuation

[Term]
id: GO:0031557
name: induction of programmed cell death in response to chemical stimulus
namespace: biological_process
def: "A process which directly activates any of the steps required for programmed cell death as a result of a chemical stimulus." [GOC:mah]
synonym: "induction of programmed cell death in response to chemical substance" EXACT []
is_a: GO:0012502 ! induction of programmed cell death
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0031558
name: induction of apoptosis in response to chemical stimulus
namespace: biological_process
def: "Any process that directly activates any of the steps required for cell death by apoptosis as a result of a chemical stimulus." [GOC:mah]
synonym: "induction of apoptosis in response to chemical substance" EXACT []
is_a: GO:0008624 ! induction of apoptosis by extracellular signals
is_a: GO:0031557 ! induction of programmed cell death in response to chemical stimulus

[Term]
id: GO:0031559
name: oxidosqualene cyclase activity
namespace: molecular_function
def: "Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene." [GOC:ct]
comment: Note that the phrase 'oxidosqualene cyclase' has been used to refer to enzymes that catalyze the reaction represented by 'lanosterol synthase activity ; GO:0000250'.
subset: gosubset_prok
synonym: "2,3-oxidosqualene cyclase activity" EXACT [GOC:mah]
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0031560
name: cellular bud neck polarisome
namespace: cellular_component
def: "Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis." [PMID:9632790]
is_a: GO:0000133 ! polarisome
relationship: part_of GO:0005935 ! cellular bud neck

[Term]
id: GO:0031561
name: cellular bud tip polarisome
namespace: cellular_component
def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal bud." [PMID:9632790]
is_a: GO:0000133 ! polarisome
relationship: part_of GO:0005934 ! cellular bud tip

[Term]
id: GO:0031562
name: hyphal tip polarisome
namespace: cellular_component
def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha." [PMID:15976451]
is_a: GO:0000133 ! polarisome
relationship: part_of GO:0001411 ! hyphal tip

[Term]
id: GO:0031563
name: mating projection tip polarisome
namespace: cellular_component
def: "Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone." [PMID:14734532]
is_a: GO:0000133 ! polarisome
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0043332 ! mating projection tip

[Term]
id: GO:0031564
name: transcription antitermination
namespace: biological_process
def: "Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond a termination site." [ISBN:0198577788, PMID:12456320]
synonym: "transcriptional readthrough" EXACT []
is_a: GO:0031555 ! transcriptional attenuation

[Term]
id: GO:0031565
name: cytokinesis checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that ensures the correct temporal ordering of nuclear division and cytokinesis; arrests the cell cycle in G2 upon perturbation of cytokinetic structures. In Schizosaccharomyces, the checkpoint monitors formation and integrity of medial actomyosin ring and septum." [GOC:mah, PMID:15647375]
synonym: "contractile ring checkpoint" EXACT []
is_a: GO:0000075 ! cell cycle checkpoint
is_a: GO:0032465 ! regulation of cytokinesis

[Term]
id: GO:0031566
name: contractile ring maintenance involved in cytokinesis during cell cycle
namespace: biological_process
def: "The cell cycle process whereby the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures. This process occurs in the context of cytokinesis that takes place as part of a cell cycle." [GOC:dph, GOC:mah, GOC:tb, GOC:vw]
synonym: "cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0032506 ! cytokinetic process
is_a: GO:0043954 ! cellular component maintenance
relationship: part_of GO:0033205 ! cytokinesis during cell cycle

[Term]
id: GO:0031567
name: cell size control checkpoint
namespace: biological_process
def: "Any cell cycle checkpoint that delays or arrests cell cycle progression until cells have reached a critical size." [GOC:mah]
is_a: GO:0007093 ! mitotic cell cycle checkpoint

[Term]
id: GO:0031568
name: G1/S transition size control checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that blocks cell cycle progression from G1 to S phase until cells have reached a critical size." [GOC:mah]
is_a: GO:0031567 ! cell size control checkpoint
is_a: GO:0031575 ! G1/S transition checkpoint

[Term]
id: GO:0031569
name: G2/M transition size control checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase until cells have reached a critical size." [GOC:mah]
is_a: GO:0031567 ! cell size control checkpoint
is_a: GO:0031576 ! G2/M transition checkpoint

[Term]
id: GO:0031570
name: DNA integrity checkpoint
namespace: biological_process
def: "Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure." [GOC:mah, GOC:vw]
is_a: GO:0000075 ! cell cycle checkpoint

[Term]
id: GO:0031571
name: G1/S DNA damage checkpoint
namespace: biological_process
def: "A G1/S transition checkpoint that blocks entry into S phase in response to DNA damage." [GOC:mah]
synonym: "G1 DNA damage checkpoint" EXACT []
is_a: GO:0000077 ! DNA damage checkpoint
is_a: GO:0031575 ! G1/S transition checkpoint

[Term]
id: GO:0031572
name: G2/M transition DNA damage checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase in response to DNA damage." [GOC:mah]
is_a: GO:0000077 ! DNA damage checkpoint
is_a: GO:0031576 ! G2/M transition checkpoint

[Term]
id: GO:0031573
name: intra-S DNA damage checkpoint
namespace: biological_process
def: "The slowing of DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progession." [GOC:vw]
is_a: GO:0000077 ! DNA damage checkpoint

[Term]
id: GO:0031574
name: S-M checkpoint
namespace: biological_process
def: "A cell cycle checkpoint which halts replication in response to nucleotide depletion." [GOC:vw]
is_a: GO:0000077 ! DNA damage checkpoint
is_a: GO:0007093 ! mitotic cell cycle checkpoint

[Term]
id: GO:0031575
name: G1/S transition checkpoint
namespace: biological_process
def: "Any cell cycle checkpoint that blocks entry into S phase." [GOC:mah]
synonym: "G1/S checkpoint" EXACT [GOC:vw]
is_a: GO:0007093 ! mitotic cell cycle checkpoint

[Term]
id: GO:0031576
name: G2/M transition checkpoint
namespace: biological_process
def: "Any cell cycle checkpoint that blocks entry into M phase." [GOC:mah]
synonym: "G2/M checkpoint" EXACT []
is_a: GO:0007093 ! mitotic cell cycle checkpoint

[Term]
id: GO:0031577
name: spindle checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:mah, PMID:15897186]
xref: Wikipedia:Spindle_checkpoint
is_a: GO:0000075 ! cell cycle checkpoint

[Term]
id: GO:0031578
name: mitotic cell cycle spindle orientation checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. The result is a cell cycle delay, usually in mitosis, until errors are corrected." [GOC:clt, PMID:14616062]
synonym: "SOC" EXACT []
synonym: "spindle position checkpoint" EXACT []
synonym: "SPOC" EXACT []
is_a: GO:0007093 ! mitotic cell cycle checkpoint
is_a: GO:0071174 ! mitotic cell cycle spindle checkpoint

[Term]
id: GO:0031579
name: membrane raft organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:dph, GOC:jl, GOC:mah]
synonym: "lipid raft organization" EXACT [GOC:mah]
synonym: "membrane raft organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016044 ! cellular membrane organization

[Term]
id: GO:0031580
name: membrane raft distribution
namespace: biological_process
def: "The process that establishes the spatial arrangement of membrane rafts within a cellular membrane." [GOC:mah]
synonym: "lipid raft distribution" EXACT []
is_a: GO:0031579 ! membrane raft organization
is_a: GO:0051665 ! membrane raft localization

[Term]
id: GO:0031581
name: hemidesmosome assembly
namespace: biological_process
def: "Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina." [GOC:dgh, PMID:15983403]
is_a: GO:0007044 ! cell-substrate junction assembly

[Term]
id: GO:0031582
name: replication fork arrest at rDNA repeats
namespace: biological_process
def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer." [GOC:mah, GOC:vw]
synonym: "replication fork arrest at ribosomal DNA repeats" EXACT []
synonym: "replication fork blocking at rDNA repeats" EXACT []
is_a: GO:0043007 ! maintenance of rDNA
is_a: GO:0043111 ! replication fork arrest

[Term]
id: GO:0031583
name: activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway
namespace: biological_process
def: "A G-protein coupled signaling pathway that results in the activation of phospholipase D, causing an increase in cellular levels of phosphatidic acid." [GOC:mah, PMID:11812783, PMID:15924269]
synonym: "G-protein signalling, phospholipase D activating pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway
is_a: GO:0031584 ! activation of phospholipase D activity

[Term]
id: GO:0031584
name: activation of phospholipase D activity
namespace: biological_process
def: "Any process that initiates the activity of inactive phospholipase D." [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0010518 ! positive regulation of phospholipase activity

[Term]
id: GO:0031585
name: regulation of inositol-1,4,5-triphosphate receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of the IP3 receptor." [GOC:dph, GOC:mah]
synonym: "regulation of IP3 receptor activity" EXACT [GOC:dph]
is_a: GO:0010469 ! regulation of receptor activity

[Term]
id: GO:0031586
name: negative regulation of inositol-1,4,5-trisphosphate receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the IP3 receptor." [GOC:dph, GOC:mah]
synonym: "down regulation of IP3 receptor activity" EXACT []
synonym: "down-regulation of IP3 receptor activity" EXACT []
synonym: "downregulation of IP3 receptor activity" EXACT []
synonym: "inhibition of IP3 receptor activity" NARROW []
synonym: "negative regulation of IP3 receptor activity" RELATED [GOC:dph]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0031585 ! regulation of inositol-1,4,5-triphosphate receptor activity
is_a: GO:0044092 ! negative regulation of molecular function

[Term]
id: GO:0031587
name: positive regulation of inositol-1,4,5-trisphosphate receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of the IP3 receptor." [GOC:dph, GOC:mah]
synonym: "activation of IP3 receptor activity" NARROW []
synonym: "positive regulation of IP3 receptor activity" EXACT [GOC:dph]
synonym: "stimulation of IP3 receptor activity" NARROW []
synonym: "up regulation of IP3 receptor activity" EXACT []
synonym: "up-regulation of IP3 receptor activity" EXACT []
synonym: "upregulation of IP3 receptor activity" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0031585 ! regulation of inositol-1,4,5-triphosphate receptor activity
is_a: GO:0044093 ! positive regulation of molecular function

[Term]
id: GO:0031588
name: AMP-activated protein kinase complex
namespace: cellular_component
def: "A protein complex that possesses AMP-dependent protein kinase activity." [GOC:mah]
synonym: "5'-AMP-activated protein kinase complex" EXACT []
synonym: "Snf1 kinase complex" NARROW []
synonym: "Snf1 serine/threonine protein kinase complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031589
name: cell-substrate adhesion
namespace: biological_process
def: "The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf]
subset: gosubset_prok
is_a: GO:0007155 ! cell adhesion

[Term]
id: GO:0031590
name: wybutosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:mah, RNAmods:037]
synonym: "wybutosine metabolism" EXACT []
synonym: "yW metabolic process" EXACT []
synonym: "yW metabolism" EXACT []
is_a: GO:0008617 ! guanosine metabolic process

[Term]
id: GO:0031591
name: wybutosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:hjd, GOC:mah, RNAmods:037]
comment: Note that wybutosine is a hypermodified G-residue, formerly called the Y-base, and its derivatives are exclusively found at position 37 (anticodon loop) of tRNAPhe.
synonym: "yW biosynthesis" EXACT []
synonym: "yW biosynthetic process" EXACT []
is_a: GO:0006400 ! tRNA modification
is_a: GO:0031590 ! wybutosine metabolic process

[Term]
id: GO:0031592
name: centrosomal corona
namespace: cellular_component
def: "An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin." [GOC:kp, GOC:mah]
comment: Note that the centrosomal corona has been observed in Dictyostelium, and is the functional equivalent of pericentriolar material.
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0031593
name: polyubiquitin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and non-covalently with a polymer of ubiqutin." [GOC:mah]
synonym: "multiubiquitin binding" RELATED []
is_a: GO:0043130 ! ubiquitin binding

[Term]
id: GO:0031594
name: neuromuscular junction
namespace: cellular_component
def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible of the muscle contraction." [GOC:nln]
xref: NIF_Subcellular:sao1124888485
xref: Wikipedia:Neuromuscular_junction
is_a: GO:0045202 ! synapse

[Term]
id: GO:0031595
name: nuclear proteasome complex
namespace: cellular_component
def: "A proteasome found in the nucleus of a cell." [GOC:mah]
is_a: GO:0000502 ! proteasome complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0031596
name: ER proteasome complex
namespace: cellular_component
def: "A proteasome found in the endoplasmic reticulum of a cell." [GOC:mah]
is_a: GO:0000502 ! proteasome complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0031597
name: cytosolic proteasome complex
namespace: cellular_component
def: "A proteasome complex found in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu, GOC:proteasome]
is_a: GO:0000502 ! proteasome complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0031598
name: nuclear proteasome regulatory particle
namespace: cellular_component
def: "The regulatory subcomplex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0005838 ! proteasome regulatory particle
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031595 ! nuclear proteasome complex

[Term]
id: GO:0031599
name: ER proteasome regulatory particle
namespace: cellular_component
def: "The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
is_a: GO:0005838 ! proteasome regulatory particle
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0031596 ! ER proteasome complex

[Term]
id: GO:0031600
name: cytosolic proteasome regulatory particle
namespace: cellular_component
def: "A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex." [GOC:mah, GOC:mtg_sensu, GOC:proteasome]
is_a: GO:0005838 ! proteasome regulatory particle
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031597 ! cytosolic proteasome complex

[Term]
id: GO:0031601
name: nuclear proteasome core complex
namespace: cellular_component
def: "The core complex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0005839 ! proteasome core complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031595 ! nuclear proteasome complex

[Term]
id: GO:0031602
name: ER proteasome core complex
namespace: cellular_component
def: "The core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
is_a: GO:0005839 ! proteasome core complex
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0031596 ! ER proteasome complex

[Term]
id: GO:0031603
name: cytosolic proteasome core complex
namespace: cellular_component
def: "The core complex of a proteasome located in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu, GOC:proteasome]
is_a: GO:0005839 ! proteasome core complex
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031597 ! cytosolic proteasome complex

[Term]
id: GO:0031604
name: nuclear proteasome core complex, alpha-subunit complex
namespace: cellular_component
def: "The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031601 ! nuclear proteasome core complex

[Term]
id: GO:0031605
name: ER proteasome core complex, alpha-subunit complex
namespace: cellular_component
def: "The subunits forming the outer ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0031602 ! ER proteasome core complex

[Term]
id: GO:0031606
name: cytosolic proteasome core complex, alpha-subunit complex
namespace: cellular_component
def: "The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu, GOC:proteasome]
is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031603 ! cytosolic proteasome core complex

[Term]
id: GO:0031607
name: nuclear proteasome core complex, beta-subunit complex
namespace: cellular_component
def: "The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0019774 ! proteasome core complex, beta-subunit complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031601 ! nuclear proteasome core complex

[Term]
id: GO:0031608
name: ER proteasome core complex, beta-subunit complex
namespace: cellular_component
def: "The subunits forming the inner ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
is_a: GO:0019774 ! proteasome core complex, beta-subunit complex
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0031602 ! ER proteasome core complex

[Term]
id: GO:0031609
name: cytosolic proteasome core complex, beta-subunit complex
namespace: cellular_component
def: "The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu, GOC:proteasome]
is_a: GO:0019774 ! proteasome core complex, beta-subunit complex
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031603 ! cytosolic proteasome core complex

[Term]
id: GO:0031610
name: nuclear proteasome regulatory particle, base subcomplex
namespace: cellular_component
def: "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle

[Term]
id: GO:0031611
name: ER proteasome regulatory particle, base subcomplex
namespace: cellular_component
def: "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0031599 ! ER proteasome regulatory particle

[Term]
id: GO:0031612
name: cytosolic proteasome regulatory particle, base subcomplex
namespace: cellular_component
def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell." [GOC:mah, GOC:mtg_sensu, GOC:proteasome]
is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle

[Term]
id: GO:0031613
name: nuclear proteasome regulatory particle, lid subcomplex
namespace: cellular_component
def: "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell." [GOC:mah]
is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle

[Term]
id: GO:0031614
name: ER proteasome regulatory particle, lid subcomplex
namespace: cellular_component
def: "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah]
is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0031599 ! ER proteasome regulatory particle

[Term]
id: GO:0031615
name: cytosolic proteasome regulatory particle, lid subcomplex
namespace: cellular_component
def: "The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:mah, GOC:mtg_sensu, GOC:proteasome]
is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex
is_a: GO:0044445 ! cytosolic part
relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle

[Term]
id: GO:0031616
name: spindle pole centrosome
namespace: cellular_component
def: "A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah]
is_a: GO:0005813 ! centrosome
relationship: part_of GO:0000922 ! spindle pole

[Term]
id: GO:0031617
name: NMS complex
namespace: cellular_component
def: "A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes." [PMID:16079914]
synonym: "Ndc80-MIND-Spc7 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000776 ! kinetochore

[Term]
id: GO:0031618
name: nuclear centromeric heterochromatin
namespace: cellular_component
def: "A region of heterochromatin located near the centromere of a chromosome in the nucleus." [GOC:mah]
synonym: "nuclear centric heterochromatin" EXACT []
is_a: GO:0005720 ! nuclear heterochromatin
is_a: GO:0005721 ! centromeric heterochromatin

[Term]
id: GO:0031619
name: homologous chromosome orientation during meiosis
namespace: biological_process
def: "The cell cycle process whereby the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, which ensures that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I." [PMID:15062096]
synonym: "homologous chromosome orientation during meiosis I" EXACT []
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0043060 ! meiotic metaphase I plate congression

[Term]
id: GO:0031620
name: regulation of fever
namespace: biological_process
def: "Any process that modulates the rate or extent of fever." [GOC:add, GOC:dph, GOC:tb]
synonym: "regulation of pyrexia" EXACT []
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0031650 ! regulation of heat generation
relationship: regulates GO:0001660 ! fever

[Term]
id: GO:0031621
name: negative regulation of fever
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of fever." [GOC:add, GOC:dph, GOC:tb]
synonym: "down regulation of fever" EXACT []
synonym: "down-regulation of fever" EXACT []
synonym: "downregulation of fever" EXACT []
synonym: "inhibition of fever" NARROW []
synonym: "negative regulation of pyrexia" EXACT []
is_a: GO:0002674 ! negative regulation of acute inflammatory response
is_a: GO:0031620 ! regulation of fever
is_a: GO:0031651 ! negative regulation of heat generation
relationship: negatively_regulates GO:0001660 ! fever

[Term]
id: GO:0031622
name: positive regulation of fever
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of fever." [GOC:add]
synonym: "activation of fever" NARROW []
synonym: "positive regulation of pyrexia" EXACT []
synonym: "stimulation of fever" NARROW []
synonym: "up regulation of fever" EXACT []
synonym: "up-regulation of fever" EXACT []
synonym: "upregulation of fever" EXACT []
is_a: GO:0002675 ! positive regulation of acute inflammatory response
is_a: GO:0031620 ! regulation of fever
is_a: GO:0031652 ! positive regulation of heat generation
relationship: positively_regulates GO:0001660 ! fever

[Term]
id: GO:0031623
name: receptor internalization
namespace: biological_process
def: "The process by which cell surface receptors are monoubiquitinated following ligand-induced activation, and subsequently taken up into endocytic vesicles and targeted to the lysosome or vacuole for degradation; serves as a mechanism to downregulate receptor signaling." [GOC:mah, PMID:15006537]
is_a: GO:0006898 ! receptor-mediated endocytosis
is_a: GO:0043112 ! receptor metabolic process

[Term]
id: GO:0031624
name: ubiquitin conjugating enzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins." [GOC:vp]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0031625
name: ubiquitin protein ligase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp]
synonym: "ubiquitin ligase binding" EXACT []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0031626
name: beta-endorphin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin." [GOC:nln, PMID:6267560]
is_a: GO:0042165 ! neurotransmitter binding

[Term]
id: GO:0031627
name: telomeric loop formation
namespace: biological_process
def: "The process by which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region." [GOC:vw, PMID:10338214]
synonym: "t-loop biosynthesis" EXACT []
synonym: "t-loop formation" EXACT []
is_a: GO:0000723 ! telomere maintenance

[Term]
id: GO:0031628
name: opioid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an opioid receptor." [GOC:nln]
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031629
name: synaptic vesicle fusion to presynaptic membrane
namespace: biological_process
def: "Fusion of the membrane of a synaptic vesicle with its target presynaptic membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [ISBN:0071120009]
synonym: "synaptic vesicle fusion" BROAD []
synonym: "synaptic vesicle internalization" RELATED []
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0016079 ! synaptic vesicle exocytosis

[Term]
id: GO:0031630
name: regulation of synaptic vesicle fusion to presynaptic membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah]
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:0046928 ! regulation of neurotransmitter secretion
relationship: regulates GO:0031629 ! synaptic vesicle fusion to presynaptic membrane

[Term]
id: GO:0031631
name: negative regulation of synaptic vesicle fusion to presynaptic membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah]
synonym: "down regulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
synonym: "down-regulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
synonym: "downregulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
synonym: "inhibition of synaptic vesicle fusion to presynaptic membrane" NARROW []
is_a: GO:0031339 ! negative regulation of vesicle fusion
is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic membrane
relationship: negatively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic membrane

[Term]
id: GO:0031632
name: positive regulation of synaptic vesicle fusion to presynaptic membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah]
synonym: "activation of synaptic vesicle fusion to presynaptic membrane" NARROW []
synonym: "stimulation of synaptic vesicle fusion to presynaptic membrane" NARROW []
synonym: "up regulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
synonym: "up-regulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
synonym: "upregulation of synaptic vesicle fusion to presynaptic membrane" EXACT []
is_a: GO:0031340 ! positive regulation of vesicle fusion
is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic membrane
relationship: positively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic membrane

[Term]
id: GO:0031633
name: xanthophore
namespace: cellular_component
def: "A chromatophore containing yellow pigment." [ISBN:0395825172]
comment: Note that this term refers to a subcellular structure, and should not be confused with the specialized cells known as xanthophores, which produce yellow pigment and are found in fish and amphibian skin. Note that several terms in the biological process ontology ('xanthophore differentiation ; GO:0050936' and its children) refer to xanthophores in the sense of pigment-producing cells.
is_a: GO:0042716 ! plasma membrane-derived chromatophore

[Term]
id: GO:0031634
name: replication fork barrier binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with replication fork barriers, sites that inhibit the progress of replication forks." [GOC:mah]
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0031635
name: inhibition of adenylate cyclase activity by opioid receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an opioid receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb]
synonym: "inhibition of adenylate cyclase activity by opioid receptor signalling pathway" EXACT [GOC:mah]
synonym: "opioid receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007193 ! inhibition of adenylate cyclase activity by G-protein signaling pathway

[Term]
id: GO:0031636
name: adrenocorticotropin-releasing hormone receptor activity
namespace: molecular_function
def: "Combining with adrenocorticotropin-releasing hormone to initiate a change in cell activity." [GOC:mah]
is_a: GO:0017047 ! adrenocorticotropin-releasing hormone binding

[Term]
id: GO:0031637
name: regulation of neuronal synaptic plasticity in response to neurotrophin
namespace: biological_process
def: "The process by which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah, PMID:8703078]
synonym: "neurotrophin-induced neuronal synaptic plasticity" EXACT []
is_a: GO:0048168 ! regulation of neuronal synaptic plasticity

[Term]
id: GO:0031638
name: zymogen activation
namespace: biological_process
def: "The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd]
synonym: "zymogen activation by proteolytic cleavage" EXACT []
is_a: GO:0051605 ! protein maturation by peptide bond cleavage

[Term]
id: GO:0031639
name: plasminogen activation
namespace: biological_process
def: "The process whereby plasminogen is processed to plasmin. This process includes both the cleavage of plasminogen between Arg560-Val561 to form plasmin and cleavage at Arg310 by plasmin or trypsin to result in the final two-chain form of plasmin held together by disulfide bonds." [GOC:hjd]
synonym: "cleavage of plasminogen to plasmin" EXACT []
is_a: GO:0031638 ! zymogen activation

[Term]
id: GO:0031640
name: killing of cells of another organism
namespace: biological_process
alt_id: GO:0001908
def: "Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add]
subset: goslim_pir
subset: gosubset_prok
synonym: "killing of cells of another, non-host, organism" NARROW []
is_a: GO:0001906 ! cell killing
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0031641
name: regulation of myelination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0051960 ! regulation of nervous system development
is_a: GO:0051969 ! regulation of transmission of nerve impulse
relationship: regulates GO:0042552 ! myelination

[Term]
id: GO:0031642
name: negative regulation of myelination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah]
synonym: "down regulation of myelination" EXACT []
synonym: "down-regulation of myelination" EXACT []
synonym: "downregulation of myelination" EXACT []
synonym: "inhibition of myelination" NARROW []
is_a: GO:0031641 ! regulation of myelination
is_a: GO:0031645 ! negative regulation of neurological system process
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0042552 ! myelination

[Term]
id: GO:0031643
name: positive regulation of myelination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah]
synonym: "activation of myelination" NARROW []
synonym: "stimulation of myelination" NARROW []
synonym: "up regulation of myelination" EXACT []
synonym: "up-regulation of myelination" EXACT []
synonym: "upregulation of myelination" EXACT []
is_a: GO:0031641 ! regulation of myelination
is_a: GO:0031646 ! positive regulation of neurological system process
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0042552 ! myelination

[Term]
id: GO:0031644
name: regulation of neurological system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of neurological process" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of neurophysiological process" EXACT []
is_a: GO:0044057 ! regulation of system process
relationship: regulates GO:0050877 ! neurological system process

[Term]
id: GO:0031645
name: negative regulation of neurological system process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of neurological process" EXACT []
synonym: "down-regulation of neurological process" EXACT []
synonym: "downregulation of neurological process" EXACT []
synonym: "inhibition of neurological process" NARROW []
synonym: "negative regulation of neurological process" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of neurophysiological process" EXACT []
is_a: GO:0031644 ! regulation of neurological system process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0050877 ! neurological system process

[Term]
id: GO:0031646
name: positive regulation of neurological system process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of neurological process" NARROW []
synonym: "positive regulation of neurological process" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of neurophysiological process" EXACT []
synonym: "stimulation of neurological process" NARROW []
synonym: "up regulation of neurological process" EXACT []
synonym: "up-regulation of neurological process" EXACT []
synonym: "upregulation of neurological process" EXACT []
is_a: GO:0031644 ! regulation of neurological system process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0050877 ! neurological system process

[Term]
id: GO:0031647
name: regulation of protein stability
namespace: biological_process
def: "Any process that affects the structure and integrity of a protein by altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0010608 ! posttranscriptional regulation of gene expression
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0031648
name: protein destabilization
namespace: biological_process
def: "Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah]
synonym: "negative regulation of protein stability" EXACT []
is_a: GO:0031647 ! regulation of protein stability

[Term]
id: GO:0031649
name: heat generation
namespace: biological_process
def: "Any homeostatic process by which an organism produces heat, thereby raising its internal temperature." [GOC:mah]
is_a: GO:0001659 ! temperature homeostasis

[Term]
id: GO:0031650
name: regulation of heat generation
namespace: biological_process
def: "Any process that modulates the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0031649 ! heat generation

[Term]
id: GO:0031651
name: negative regulation of heat generation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of heat generation" EXACT []
synonym: "down-regulation of heat generation" EXACT []
synonym: "downregulation of heat generation" EXACT []
synonym: "inhibition of heat generation" NARROW []
is_a: GO:0031650 ! regulation of heat generation
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0031649 ! heat generation

[Term]
id: GO:0031652
name: positive regulation of heat generation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of heat generation" NARROW []
synonym: "stimulation of heat generation" NARROW []
synonym: "up regulation of heat generation" EXACT []
synonym: "up-regulation of heat generation" EXACT []
synonym: "upregulation of heat generation" EXACT []
is_a: GO:0031650 ! regulation of heat generation
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0031649 ! heat generation

[Term]
id: GO:0031653
name: heat dissipation
namespace: biological_process
def: "Any homeostatic process by which an organism releases excess heat to the environment, thereby lowering its internal temperature." [GOC:mah]
is_a: GO:0001659 ! temperature homeostasis

[Term]
id: GO:0031654
name: regulation of heat dissipation
namespace: biological_process
def: "Any process that modulates the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0031653 ! heat dissipation

[Term]
id: GO:0031655
name: negative regulation of heat dissipation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of heat dissipation" EXACT []
synonym: "down-regulation of heat dissipation" EXACT []
synonym: "downregulation of heat dissipation" EXACT []
synonym: "inhibition of heat dissipation" NARROW []
is_a: GO:0031654 ! regulation of heat dissipation
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0031653 ! heat dissipation

[Term]
id: GO:0031656
name: positive regulation of heat dissipation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb]
synonym: "activation of heat dissipation" NARROW []
synonym: "stimulation of heat dissipation" NARROW []
synonym: "up regulation of heat dissipation" EXACT []
synonym: "up-regulation of heat dissipation" EXACT []
synonym: "upregulation of heat dissipation" EXACT []
is_a: GO:0031654 ! regulation of heat dissipation
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0031653 ! heat dissipation

[Term]
id: GO:0031657
name: regulation of cyclin-dependent protein kinase activity during G1/S
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle." [GOC:mah]
synonym: "G1/S-specific regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000079 ! regulation of cyclin-dependent protein kinase activity
relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle

[Term]
id: GO:0031658
name: negative regulation of cyclin-dependent protein kinase activity during G1/S
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "G1/S-specific down regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific down-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific downregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific inhibition of cyclin-dependent protein kinase activity" NARROW []
synonym: "G1/S-specific negative regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031657 ! regulation of cyclin-dependent protein kinase activity during G1/S
is_a: GO:0045736 ! negative regulation of cyclin-dependent protein kinase activity

[Term]
id: GO:0031659
name: positive regulation of cyclin-dependent protein kinase activity during G1/S
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CDK activity during the G1/S transition of the cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "G1/S-specific activation of cyclin-dependent protein kinase activity" NARROW []
synonym: "G1/S-specific positive regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
synonym: "G1/S-specific stimulation of cyclin-dependent protein kinase activity" NARROW []
synonym: "G1/S-specific up regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific up-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G1/S-specific upregulation of cyclin-dependent protein kinase activity" EXACT []
is_a: GO:0031657 ! regulation of cyclin-dependent protein kinase activity during G1/S
is_a: GO:0045737 ! positive regulation of cyclin-dependent protein kinase activity

[Term]
id: GO:0031660
name: regulation of cyclin-dependent protein kinase activity during G2/M
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "G2/M-specific regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000079 ! regulation of cyclin-dependent protein kinase activity
relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle

[Term]
id: GO:0031661
name: negative regulation of cyclin-dependent protein kinase activity during G2/M
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "G2/M-specific down regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific down-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific downregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific inhibition of cyclin-dependent protein kinase activity" NARROW []
synonym: "G2/M-specific negative regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031660 ! regulation of cyclin-dependent protein kinase activity during G2/M
is_a: GO:0045736 ! negative regulation of cyclin-dependent protein kinase activity

[Term]
id: GO:0031662
name: positive regulation of cyclin-dependent protein kinase activity during G2/M
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CDK activity during the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "G2/M-specific activation of cyclin-dependent protein kinase activity" NARROW []
synonym: "G2/M-specific positive regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb]
synonym: "G2/M-specific stimulation of cyclin-dependent protein kinase activity" NARROW []
synonym: "G2/M-specific up regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific up-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "G2/M-specific upregulation of cyclin-dependent protein kinase activity" EXACT []
is_a: GO:0031660 ! regulation of cyclin-dependent protein kinase activity during G2/M
is_a: GO:0045737 ! positive regulation of cyclin-dependent protein kinase activity

[Term]
id: GO:0031663
name: lipopolysaccharide-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated in response to detection of lipopolysaccharide." [GOC:mah]
synonym: "lipopolysaccharide-mediated signalling pathway" EXACT []
synonym: "LPS-mediated signaling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor linked signaling pathway
is_a: GO:0023034 ! intracellular signaling pathway

[Term]
id: GO:0031664
name: regulation of lipopolysaccharide-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah]
synonym: "regulation of lipopolysaccharide-mediated signalling pathway" EXACT []
synonym: "regulation of LPS-mediated signaling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway

[Term]
id: GO:0031665
name: negative regulation of lipopolysaccharide-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah]
synonym: "down regulation of lipopolysaccharide-mediated signaling pathway" EXACT []
synonym: "down-regulation of lipopolysaccharide-mediated signaling pathway" EXACT []
synonym: "downregulation of lipopolysaccharide-mediated signaling pathway" EXACT []
synonym: "inhibition of lipopolysaccharide-mediated signaling pathway" NARROW []
synonym: "negative regulation of lipopolysaccharide-mediated signalling pathway" EXACT []
synonym: "negative regulation of LPS-mediated signaling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0031664 ! regulation of lipopolysaccharide-mediated signaling pathway
relationship: negatively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway

[Term]
id: GO:0031666
name: positive regulation of lipopolysaccharide-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah]
synonym: "activation of lipopolysaccharide-mediated signaling pathway" NARROW []
synonym: "positive regulation of lipopolysaccharide-mediated signalling pathway" EXACT []
synonym: "positive regulation of LPS-mediated signaling pathway" EXACT []
synonym: "stimulation of lipopolysaccharide-mediated signaling pathway" NARROW []
synonym: "up regulation of lipopolysaccharide-mediated signaling pathway" EXACT []
synonym: "up-regulation of lipopolysaccharide-mediated signaling pathway" EXACT []
synonym: "upregulation of lipopolysaccharide-mediated signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0031664 ! regulation of lipopolysaccharide-mediated signaling pathway
relationship: positively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway

[Term]
id: GO:0031667
name: response to nutrient levels
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah]
subset: gosubset_prok
is_a: GO:0009991 ! response to extracellular stimulus

[Term]
id: GO:0031668
name: cellular response to extracellular stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:mah]
subset: gosubset_prok
is_a: GO:0007154 ! cell communication
is_a: GO:0009991 ! response to extracellular stimulus
is_a: GO:0051716 ! cellular response to stimulus
is_a: GO:0071496 ! cellular response to external stimulus

[Term]
id: GO:0031669
name: cellular response to nutrient levels
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah]
subset: gosubset_prok
is_a: GO:0031667 ! response to nutrient levels
is_a: GO:0031668 ! cellular response to extracellular stimulus

[Term]
id: GO:0031670
name: cellular response to nutrient
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:mah]
is_a: GO:0007584 ! response to nutrient
is_a: GO:0031669 ! cellular response to nutrient levels
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0031671
name: primary cell septum biogenesis
namespace: biological_process
def: "The process by which a primary cell septum is synthesized, aggregates, and bonds together following nuclear division." [GOC:jl]
is_a: GO:0032506 ! cytokinetic process
is_a: GO:0044085 ! cellular component biogenesis
relationship: part_of GO:0000917 ! barrier septum formation

[Term]
id: GO:0031672
name: A band
namespace: cellular_component
def: "The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line." [ISBN:0321204131]
synonym: "A disc" EXACT []
synonym: "anisotropic disc" EXACT []
synonym: "Q disc" EXACT []
synonym: "transverse disc" EXACT []
xref: Wikipedia:Sarcomere#bands
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030017 ! sarcomere

[Term]
id: GO:0031673
name: H zone
namespace: cellular_component
def: "A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments." [GOC:mtg_muscle, ISBN:0321204131]
synonym: "H band" EXACT []
synonym: "H disc" EXACT []
xref: Wikipedia:Sarcomere#bands
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0031672 ! A band

[Term]
id: GO:0031674
name: I band
namespace: cellular_component
def: "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131]
synonym: "I disc" EXACT []
synonym: "isotropic disc" EXACT []
synonym: "J disc" EXACT []
xref: Wikipedia:Sarcomere#bands
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030017 ! sarcomere

[Term]
id: GO:0031676
name: plasma membrane-derived thylakoid membrane
namespace: cellular_component
def: "The pigmented membrane of a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu]
synonym: "plasma membrane thylakoid membrane" EXACT []
is_a: GO:0042651 ! thylakoid membrane
is_a: GO:0042717 ! plasma membrane-derived chromatophore membrane
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0030075 ! plasma membrane-derived thylakoid

[Term]
id: GO:0031679
name: NADH dehydrogenase (plastoquinone) activity
namespace: molecular_function
alt_id: GO:0030024
def: "Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol." [EC:1.6.99.6, GOC:mah]
synonym: "NADH:plastoquinone reductase activity" EXACT []
is_a: GO:0050136 ! NADH dehydrogenase (quinone) activity

[Term]
id: GO:0031680
name: G-protein beta/gamma-subunit complex
namespace: cellular_component
def: "The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange." [GOC:mah]
comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'.
synonym: "G-beta/G-gamma complex" EXACT []
synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0031681
name: G-protein beta-subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a G-protein beta subunit." [GOC:mah]
synonym: "G-beta protein subunit binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031682
name: G-protein gamma-subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a G-protein gamma subunit." [GOC:mah]
synonym: "G-gamma protein subunit binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031683
name: G-protein beta/gamma-subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits." [GOC:nln]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0031684
name: heterotrimeric G-protein complex cycle
namespace: biological_process
def: "The series of molecular events that generate a signal through the activation of G-protein subunits and recycling of these subunits." [GOC:nln]
is_a: GO:0043087 ! regulation of GTPase activity
relationship: part_of GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0031685
name: adenosine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an adenosine receptor." [GOC:mah, GOC:nln]
synonym: "adenosine receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031686
name: A1 adenosine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an A1 adenosine receptor." [GOC:mah, GOC:nln]
synonym: "A1 adenosine receptor ligand" NARROW []
is_a: GO:0031685 ! adenosine receptor binding

[Term]
id: GO:0031687
name: A2A adenosine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an A2A adenosine receptor." [GOC:mah, GOC:nln]
synonym: "A2A adenosine receptor ligand" NARROW []
is_a: GO:0031685 ! adenosine receptor binding

[Term]
id: GO:0031688
name: A2B adenosine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an A2B adenosine receptor." [GOC:mah, GOC:nln]
synonym: "A2B adenosine receptor ligand" NARROW []
is_a: GO:0031685 ! adenosine receptor binding

[Term]
id: GO:0031689
name: A3 adenosine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an A3 adenosine receptor." [GOC:mah, GOC:nln]
synonym: "A3 adenosine receptor ligand" NARROW []
is_a: GO:0031685 ! adenosine receptor binding

[Term]
id: GO:0031690
name: adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "adrenergic receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031691
name: alpha-1A adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alpha-1A adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-1A adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031692
name: alpha-1B adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alpha-1B adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-1B adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031693
name: alpha-1D adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alpha-1D adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-1D adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031694
name: alpha-2A adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alpha-2A adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-2A adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031695
name: alpha-2B adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alpha-2B adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-2B adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031696
name: alpha-2C adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alpha-2C adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "alpha-2C adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031697
name: beta-1 adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a beta-1 adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "beta-1 adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031698
name: beta-2 adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a beta-2 adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "beta-2 adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031699
name: beta-3 adrenergic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a beta-3 adrenergic receptor." [GOC:mah, GOC:nln]
synonym: "beta-3 adrenergic receptor ligand" NARROW []
is_a: GO:0031690 ! adrenergic receptor binding

[Term]
id: GO:0031700
name: adrenomedullin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an adrenomedullin receptor." [GOC:mah, GOC:nln]
synonym: "adrenomedullin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031701
name: angiotensin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an angiotensin receptor." [GOC:mah, GOC:nln]
synonym: "angiotensin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031702
name: type 1 angiotensin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 angiotensin receptor." [GOC:mah, GOC:nln]
synonym: "AT1 receptor binding" EXACT []
synonym: "type 1 angiotensin receptor ligand" NARROW []
is_a: GO:0031701 ! angiotensin receptor binding

[Term]
id: GO:0031703
name: type 2 angiotensin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 angiotensin receptor." [GOC:mah, GOC:nln]
synonym: "AT2 receptor binding" EXACT []
synonym: "type 2 angiotensin receptor ligand" NARROW []
is_a: GO:0031701 ! angiotensin receptor binding

[Term]
id: GO:0031704
name: apelin receptor binding
namespace: molecular_function
alt_id: GO:0042569
def: "Interacting selectively and non-covalently with an apelin receptor." [GOC:mah, GOC:nln, GOC:vp, PMID:12787050]
synonym: "apelin receptor ligand" NARROW []
synonym: "APJ receptor binding" EXACT []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031705
name: bombesin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a bombesin receptor." [GOC:mah, GOC:nln]
synonym: "bombesin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031706
name: subtype 3 bombesin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a subtype 3 bombesin receptor." [GOC:mah, GOC:nln]
synonym: "subtype 3 bombesin receptor ligand" NARROW []
is_a: GO:0031705 ! bombesin receptor binding

[Term]
id: GO:0031707
name: endothelin A receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an endothelin A receptor." [GOC:mah, GOC:nln]
synonym: "endothelin A receptor ligand" NARROW []
synonym: "endothelin-1 receptor binding" EXACT []
is_a: GO:0031705 ! bombesin receptor binding

[Term]
id: GO:0031708
name: endothelin B receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an endothelin B receptor." [GOC:mah, GOC:nln]
synonym: "endothelin B receptor ligand" NARROW []
is_a: GO:0031705 ! bombesin receptor binding

[Term]
id: GO:0031709
name: gastrin-releasing peptide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a gastrin-releasing peptide receptor." [GOC:mah, GOC:nln]
synonym: "gastrin-releasing peptide receptor ligand" NARROW []
synonym: "GRP receptor binding" EXACT []
is_a: GO:0031705 ! bombesin receptor binding

[Term]
id: GO:0031710
name: neuromedin B receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neuromedin B receptor." [GOC:mah, GOC:nln]
synonym: "neuromedin B receptor ligand" NARROW []
is_a: GO:0031705 ! bombesin receptor binding

[Term]
id: GO:0031711
name: bradykinin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a bradykinin receptor." [GOC:mah, GOC:nln]
synonym: "bradykinin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031712
name: B1 bradykinin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a B1 bradykinin receptor." [GOC:mah, GOC:nln]
synonym: "B1 bradykinin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031713
name: B2 bradykinin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a B2 bradykinin receptor." [GOC:mah, GOC:nln]
synonym: "B2 bradykinin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031714
name: C5a anaphylatoxin chemotactic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a C5a anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln]
synonym: "C5a anaphylatoxin chemotactic receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031715
name: C5L2 anaphylatoxin chemotactic receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a C5L2 anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln]
synonym: "C5L2 anaphylatoxin chemotactic receptor ligand" NARROW []
is_a: GO:0031714 ! C5a anaphylatoxin chemotactic receptor binding

[Term]
id: GO:0031716
name: calcitonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a calcitonin receptor." [GOC:mah, GOC:nln]
synonym: "calcitonin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031717
name: cannabinoid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cannabinoid receptor." [GOC:mah, GOC:nln]
synonym: "cannabinoid receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031718
name: type 1 cannabinoid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 cannabinoid receptor." [GOC:mah, GOC:nln]
synonym: "type 1 cannabinoid receptor ligand" NARROW []
is_a: GO:0031717 ! cannabinoid receptor binding

[Term]
id: GO:0031719
name: type 2 cannabinoid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 cannabinoid receptor." [GOC:mah, GOC:nln]
synonym: "type 2 cannabinoid receptor ligand" NARROW []
is_a: GO:0031717 ! cannabinoid receptor binding

[Term]
id: GO:0031720
name: haptoglobin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0031721
name: hemoglobin alpha binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a hemoglobin alpha chain." [GOC:mah]
is_a: GO:0030492 ! hemoglobin binding

[Term]
id: GO:0031722
name: hemoglobin beta binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a hemoglobin beta chain." [GOC:mah]
is_a: GO:0030492 ! hemoglobin binding

[Term]
id: GO:0031723
name: CXCR4 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CXCR4 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CXCR4 chemokine receptor ligand" NARROW []
synonym: "stromal cell-derived factor 1 receptor binding" EXACT []
is_a: GO:0045236 ! CXCR chemokine receptor binding

[Term]
id: GO:0031724
name: CXCR5 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CXCR5 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CXCR5 chemokine receptor ligand" NARROW []
synonym: "type 1 Burkitt's lymphoma receptor binding" EXACT []
is_a: GO:0045236 ! CXCR chemokine receptor binding

[Term]
id: GO:0031725
name: CXCR6 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CXCR6 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "bonzo receptor binding" EXACT []
synonym: "CXCR6 chemokine receptor ligand" NARROW []
synonym: "STRL33 receptor binding" EXACT []
is_a: GO:0045236 ! CXCR chemokine receptor binding

[Term]
id: GO:0031726
name: CCR1 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR1 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR1 chemokine receptor ligand" NARROW []
synonym: "macrophage inflammatory protein-1 alpha receptor binding" EXACT []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031727
name: CCR2 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR2 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR2 chemokine receptor ligand" NARROW []
synonym: "monocyte chemoattractant protein 1 receptor binding" EXACT []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031728
name: CCR3 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR3 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR3 chemokine receptor ligand" NARROW []
synonym: "eosinophil eotaxin receptor binding" EXACT []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031729
name: CCR4 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR4 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR4 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031730
name: CCR5 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR5 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR5 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031731
name: CCR6 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR6 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR6 chemokine receptor ligand" NARROW []
synonym: "LARC receptor binding" EXACT []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031732
name: CCR7 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR7 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR7 chemokine receptor ligand" NARROW []
synonym: "MIP-3 beta receptor binding" EXACT []
synonym: "type 1 EBV-induced G-protein coupled receptor binding" EXACT []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031733
name: CCR8 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR8 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR8 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031734
name: CCR9 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR9 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR9 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031735
name: CCR10 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR10 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR10 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031736
name: CCR11 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR11 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CCR11 chemokine receptor ligand" NARROW []
is_a: GO:0048020 ! CCR chemokine receptor binding

[Term]
id: GO:0031737
name: CX3C chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CX3C chemokine receptor." [GOC:mah, GOC:nln]
synonym: "CX3C chemokine receptor ligand" NARROW []
synonym: "fractalkine receptor binding" EXACT []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031738
name: XCR1 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a XCR1 chemokine receptor." [GOC:mah, GOC:nln]
synonym: "lymphotactin receptor binding" EXACT []
synonym: "XCR1 chemokine receptor ligand" NARROW []
is_a: GO:0042379 ! chemokine receptor binding

[Term]
id: GO:0031739
name: cholecystokinin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cholecystokinin receptor." [GOC:mah, GOC:nln]
synonym: "cholecystokinin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031740
name: type A cholecystokinin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type A cholecystokinin receptor." [GOC:mah, GOC:nln]
synonym: "type A cholecystokinin receptor ligand" NARROW []
is_a: GO:0031739 ! cholecystokinin receptor binding

[Term]
id: GO:0031741
name: type B gastrin/cholecystokinin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type B gastrin/cholecystokinin receptor." [GOC:mah, GOC:nln]
synonym: "type B gastrin/cholecystokinin receptor ligand" NARROW []
is_a: GO:0031739 ! cholecystokinin receptor binding

[Term]
id: GO:0031742
name: corticotropin releasing factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a corticotropin releasing factor receptor." [GOC:mah, GOC:nln]
synonym: "corticotropin releasing factor receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031743
name: type 1 corticotropin releasing factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 corticotropin releasing factor receptor." [GOC:mah, GOC:nln]
synonym: "type 1 corticotropin releasing factor receptor ligand" NARROW []
is_a: GO:0031742 ! corticotropin releasing factor receptor binding

[Term]
id: GO:0031744
name: type 2 corticotropin releasing factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 corticotropin releasing factor receptor." [GOC:mah, GOC:nln]
synonym: "type 2 corticotropin releasing factor receptor ligand" NARROW []
is_a: GO:0031742 ! corticotropin releasing factor receptor binding

[Term]
id: GO:0031745
name: cysteinyl leukotriene receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cysteinyl leukotriene receptor." [GOC:mah, GOC:nln]
synonym: "cysteinyl leukotriene receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031746
name: type 1 cysteinyl leukotriene receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln]
synonym: "type 1 cysteinyl leukotriene receptor ligand" NARROW []
is_a: GO:0031745 ! cysteinyl leukotriene receptor binding

[Term]
id: GO:0031747
name: type 2 cysteinyl leukotriene receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln]
synonym: "type 2 cysteinyl leukotriene receptor ligand" NARROW []
is_a: GO:0031745 ! cysteinyl leukotriene receptor binding

[Term]
id: GO:0031748
name: D1 dopamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a D1 dopamine receptor." [GOC:mah, GOC:nln]
synonym: "D1 dopamine receptor ligand" NARROW []
synonym: "D1A dopamine receptor binding" EXACT []
is_a: GO:0050780 ! dopamine receptor binding

[Term]
id: GO:0031749
name: D2 dopamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a D2 dopamine receptor." [GOC:mah, GOC:nln]
synonym: "D2 dopamine receptor ligand" NARROW []
is_a: GO:0050780 ! dopamine receptor binding

[Term]
id: GO:0031750
name: D3 dopamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a D3 dopamine receptor." [GOC:mah, GOC:nln]
synonym: "D3 dopamine receptor ligand" NARROW []
is_a: GO:0050780 ! dopamine receptor binding

[Term]
id: GO:0031751
name: D4 dopamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a D4 dopamine receptor." [GOC:mah, GOC:nln]
synonym: "D4 dopamine receptor ligand" NARROW []
is_a: GO:0050780 ! dopamine receptor binding

[Term]
id: GO:0031752
name: D5 dopamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a D5 dopamine receptor." [GOC:mah, GOC:nln]
synonym: "D1B dopamine receptor binding" EXACT []
synonym: "D5 dopamine receptor ligand" NARROW []
is_a: GO:0050780 ! dopamine receptor binding

[Term]
id: GO:0031753
name: endothelial differentiation G-protein coupled receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an endothelial differentiation G-protein coupled receptor." [GOC:mah, GOC:nln]
synonym: "endothelial differentiation G-protein coupled receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031754
name: Edg-1 sphingosine 1-phosphate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an Edg-1 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln]
synonym: "Edg-1 sphingosine 1-phosphate receptor ligand" NARROW []
is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding

[Term]
id: GO:0031755
name: Edg-2 lysophosphatidic acid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an Edg-2 lysophosphatidic acid receptor." [GOC:mah, GOC:nln]
synonym: "Edg-2 lysophosphatidic acid receptor ligand" NARROW []
synonym: "LPA1 receptor binding" EXACT []
is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding

[Term]
id: GO:0031756
name: Edg-3 sphingosine 1-phosphate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an Edg-3 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln]
synonym: "Edg-3 sphingosine 1-phosphate receptor ligand" NARROW []
is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding

[Term]
id: GO:0031757
name: Edg-4 lysophosphatidic acid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an Edg-4 lysophosphatidic acid receptor." [GOC:mah, GOC:nln]
synonym: "Edg-4 lysophosphatidic acid receptor ligand" NARROW []
synonym: "LPA2 receptor binding" EXACT []
is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding

[Term]
id: GO:0031758
name: Edg-5 sphingosine 1-phosphate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an Edg-5 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln]
synonym: "Edg-5 sphingosine 1-phosphate receptor ligand" NARROW []
is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding

[Term]
id: GO:0031759
name: Edg-6 sphingosine 1-phosphate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an Edg-6 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln]
synonym: "Edg-6 sphingosine 1-phosphate receptor ligand" NARROW []
is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding

[Term]
id: GO:0031760
name: Edg-7 lysophosphatidic acid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an Edg-7 lysophosphatidic acid receptor." [GOC:mah, GOC:nln]
synonym: "Edg-7 lysophosphatidic acid receptor ligand" NARROW []
synonym: "LPA3 receptor binding" EXACT []
is_a: GO:0031753 ! endothelial differentiation G-protein coupled receptor binding

[Term]
id: GO:0031761
name: fMet-Leu-Phe receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a fMet-Leu-Phe receptor." [GOC:mah, GOC:nln]
synonym: "fMet-Leu-Phe receptor ligand" NARROW []
synonym: "N-formyl peptide receptor binding" EXACT []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031762
name: follicle stimulating hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a follicle stimulating hormone receptor." [GOC:mah, GOC:nln]
synonym: "follicle stimulating hormone receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031763
name: galanin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a galanin receptor." [GOC:mah, GOC:nln]
synonym: "galanin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031764
name: type 1 galanin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 galanin receptor." [GOC:mah, GOC:nln]
synonym: "type 1 galanin receptor ligand" NARROW []
is_a: GO:0031763 ! galanin receptor binding

[Term]
id: GO:0031765
name: type 2 galanin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 galanin receptor." [GOC:mah, GOC:nln]
synonym: "type 2 galanin receptor ligand" NARROW []
is_a: GO:0031763 ! galanin receptor binding

[Term]
id: GO:0031766
name: type 3 galanin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 3 galanin receptor." [GOC:mah, GOC:nln]
synonym: "type 3 galanin receptor ligand" NARROW []
is_a: GO:0031763 ! galanin receptor binding

[Term]
id: GO:0031767
name: gastric inhibitory polypeptide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a gastric inhibitory polypeptide receptor." [GOC:mah, GOC:nln]
synonym: "gastric inhibitory polypeptide receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031768
name: ghrelin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ghrelin receptor." [GOC:mah, GOC:nln]
synonym: "ghrelin receptor ligand" NARROW []
synonym: "type 1 growth hormone secretagogue GH-releasing peptide receptor binding" EXACT []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031769
name: glucagon receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a glucagon receptor." [GOC:mah, GOC:nln]
synonym: "glucagon receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031770
name: growth hormone-releasing hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a growth hormone-releasing hormone receptor." [GOC:mah, GOC:nln]
synonym: "growth hormone-releasing hormone receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031771
name: type 1 hypocretin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 hypocretin receptor." [GOC:mah, GOC:nln]
synonym: "type 1 hypocretin receptor ligand" NARROW []
synonym: "type 1 orexin receptor binding" EXACT []
is_a: GO:0042324 ! hypocretin receptor binding

[Term]
id: GO:0031772
name: type 2 hypocretin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 hypocretin receptor." [GOC:mah, GOC:nln]
synonym: "type 2 hypocretin receptor ligand" NARROW []
synonym: "type 2 orexin receptor binding" EXACT []
is_a: GO:0042324 ! hypocretin receptor binding

[Term]
id: GO:0031773
name: kisspeptin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a kisspeptin receptor." [GOC:mah, GOC:nln]
synonym: "G-protein coupled receptor 54 binding" EXACT []
synonym: "hOT7T175 receptor binding" EXACT []
synonym: "hypogonadotropin-1 receptor binding" EXACT []
synonym: "KiSS-1 receptor binding" EXACT []
synonym: "kisspeptin receptor ligand" NARROW []
synonym: "metastin receptor binding" EXACT []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031774
name: leukotriene receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a leukotriene receptor." [GOC:mah, GOC:nln]
synonym: "leukotriene receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031775
name: lutropin-choriogonadotropic hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lutropin-choriogonadotropic hormone receptor." [GOC:mah, GOC:nln]
synonym: "lutropin-choriogonadotropic hormone receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031776
name: melanin-concentrating hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a melanin-concentrating hormone receptor." [GOC:mah, GOC:nln]
synonym: "melanin-concentrating hormone receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031777
name: type 1 melanin-concentrating hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln]
synonym: "type 1 melanin-concentrating hormone receptor ligand" NARROW []
is_a: GO:0031776 ! melanin-concentrating hormone receptor binding

[Term]
id: GO:0031778
name: type 2 melanin-concentrating hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln]
synonym: "type 2 melanin-concentrating hormone receptor ligand" NARROW []
is_a: GO:0031776 ! melanin-concentrating hormone receptor binding

[Term]
id: GO:0031779
name: melanocortin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a melanocortin receptor." [GOC:mah, GOC:nln]
synonym: "melanocortin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031780
name: adrenocorticotropin hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an adrenocorticotropin hormone receptor." [GOC:dph, GOC:mah, GOC:nln]
synonym: "ACTH receptor binding" EXACT []
synonym: "adrenocorticotropic hormone receptor ligand" NARROW []
is_a: GO:0031779 ! melanocortin receptor binding

[Term]
id: GO:0031781
name: type 3 melanocortin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 3 melanocortin receptor." [GOC:mah, GOC:nln]
synonym: "type 3 melanocortin receptor ligand" NARROW []
is_a: GO:0031779 ! melanocortin receptor binding

[Term]
id: GO:0031782
name: type 4 melanocortin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 4 melanocortin receptor." [GOC:mah, GOC:nln]
synonym: "type 4 melanocortin receptor ligand" NARROW []
is_a: GO:0031779 ! melanocortin receptor binding

[Term]
id: GO:0031783
name: type 5 melanocortin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 5 melanocortin receptor." [GOC:mah, GOC:nln]
synonym: "type 5 melanocortin receptor ligand" NARROW []
is_a: GO:0031779 ! melanocortin receptor binding

[Term]
id: GO:0031784
name: melatonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a melatonin receptor." [GOC:mah, GOC:nln]
synonym: "melatonin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031785
name: type 1A melatonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1A melatonin receptor." [GOC:mah, GOC:nln]
synonym: "type 1A melatonin receptor ligand" NARROW []
is_a: GO:0031784 ! melatonin receptor binding

[Term]
id: GO:0031786
name: type 1B melatonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1B melatonin receptor." [GOC:mah, GOC:nln]
synonym: "type 1B melatonin receptor ligand" NARROW []
is_a: GO:0031784 ! melatonin receptor binding

[Term]
id: GO:0031787
name: H9 melatonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a H9 melatonin receptor." [GOC:mah, GOC:nln]
synonym: "H9 melatonin receptor ligand" NARROW []
is_a: GO:0031784 ! melatonin receptor binding

[Term]
id: GO:0031788
name: motilin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a motilin receptor." [GOC:mah, GOC:nln]
synonym: "motilin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031789
name: muscarinic acetylcholine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a muscarinic acetylcholine receptor." [GOC:mah, GOC:nln]
synonym: "muscarinic acetylcholine receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031790
name: M1 muscarinic acetylcholine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a M1 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln]
synonym: "M1 muscarinic acetylcholine receptor ligand" NARROW []
is_a: GO:0031789 ! muscarinic acetylcholine receptor binding

[Term]
id: GO:0031791
name: M2 muscarinic acetylcholine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a M2 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln]
synonym: "M2 muscarinic acetylcholine receptor ligand" NARROW []
is_a: GO:0031789 ! muscarinic acetylcholine receptor binding

[Term]
id: GO:0031792
name: M3 muscarinic acetylcholine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a M3 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln]
synonym: "M3 muscarinic acetylcholine receptor ligand" NARROW []
is_a: GO:0031789 ! muscarinic acetylcholine receptor binding

[Term]
id: GO:0031793
name: M4 muscarinic acetylcholine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a M4 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln]
synonym: "M4 muscarinic acetylcholine receptor ligand" NARROW []
is_a: GO:0031789 ! muscarinic acetylcholine receptor binding

[Term]
id: GO:0031794
name: M5 muscarinic acetylcholine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a M5 muscarinic acetylcholine receptor." [GOC:mah, GOC:nln]
synonym: "M5 muscarinic acetylcholine receptor ligand" NARROW []
is_a: GO:0031789 ! muscarinic acetylcholine receptor binding

[Term]
id: GO:0031795
name: metabotropic GABA receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a metabotropic GABA receptor." [GOC:mah, GOC:nln]
synonym: "GABAB receptor binding" EXACT []
synonym: "metabotropic GABA receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031796
name: type 1 metabotropic GABA receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 metabotropic GABA receptor." [GOC:mah, GOC:nln]
synonym: "type 1 metabotropic GABA receptor ligand" NARROW []
is_a: GO:0031795 ! metabotropic GABA receptor binding

[Term]
id: GO:0031797
name: type 2 metabotropic GABA receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 metabotropic GABA receptor." [GOC:mah, GOC:nln]
synonym: "type 2 metabotropic GABA receptor ligand" NARROW []
is_a: GO:0031795 ! metabotropic GABA receptor binding

[Term]
id: GO:0031798
name: type 1 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 1 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! metabotropic glutamate receptor binding

[Term]
id: GO:0031799
name: type 2 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 2 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! metabotropic glutamate receptor binding

[Term]
id: GO:0031800
name: type 3 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 3 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 3 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! metabotropic glutamate receptor binding

[Term]
id: GO:0031801
name: type 4 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 4 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 4 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! metabotropic glutamate receptor binding

[Term]
id: GO:0031802
name: type 5 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 5 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 5 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! metabotropic glutamate receptor binding

[Term]
id: GO:0031803
name: type 6 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 6 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 6 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! metabotropic glutamate receptor binding

[Term]
id: GO:0031804
name: type 7 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 7 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 7 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! metabotropic glutamate receptor binding

[Term]
id: GO:0031805
name: type 8 metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 8 metabotropic glutamate receptor." [GOC:mah, GOC:nln]
synonym: "type 8 metabotropic glutamate receptor ligand" NARROW []
is_a: GO:0035256 ! metabotropic glutamate receptor binding

[Term]
id: GO:0031806
name: metabotropic histamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a metabotropic histamine receptor." [GOC:mah, GOC:nln]
synonym: "metabotropic histamine receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031807
name: H1 histamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a H1 histamine receptor." [GOC:mah, GOC:nln]
synonym: "H1 histamine receptor ligand" NARROW []
is_a: GO:0031806 ! metabotropic histamine receptor binding

[Term]
id: GO:0031808
name: H2 histamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a H2 histamine receptor." [GOC:mah, GOC:nln]
synonym: "H2 histamine receptor ligand" NARROW []
is_a: GO:0031806 ! metabotropic histamine receptor binding

[Term]
id: GO:0031809
name: H3 histamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a H3 histamine receptor." [GOC:mah, GOC:nln]
synonym: "H3 histamine receptor ligand" NARROW []
is_a: GO:0031806 ! metabotropic histamine receptor binding

[Term]
id: GO:0031810
name: H4 histamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a H4 histamine receptor." [GOC:mah, GOC:nln]
synonym: "H4 histamine receptor ligand" NARROW []
is_a: GO:0031806 ! metabotropic histamine receptor binding

[Term]
id: GO:0031811
name: metabotropic nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a metabotropic nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "metabotropic nucleotide receptor ligand" NARROW []
synonym: "P2Y receptor binding" EXACT []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031812
name: P2Y1 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y1 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y1 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! metabotropic nucleotide receptor binding

[Term]
id: GO:0031813
name: P2Y2 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y2 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y2 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! metabotropic nucleotide receptor binding

[Term]
id: GO:0031814
name: P2Y4 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y4 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y4 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! metabotropic nucleotide receptor binding

[Term]
id: GO:0031815
name: P2Y5 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y5 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y5 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! metabotropic nucleotide receptor binding

[Term]
id: GO:0031816
name: P2Y6 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y6 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y6 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! metabotropic nucleotide receptor binding

[Term]
id: GO:0031817
name: P2Y8 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y8 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y8 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! metabotropic nucleotide receptor binding

[Term]
id: GO:0031818
name: P2Y9 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y9 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y9 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! metabotropic nucleotide receptor binding

[Term]
id: GO:0031819
name: P2Y10 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y10 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y10 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! metabotropic nucleotide receptor binding

[Term]
id: GO:0031820
name: P2Y11 nucleotide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a P2Y11 nucleotide receptor." [GOC:mah, GOC:nln]
synonym: "P2Y11 nucleotide receptor ligand" NARROW []
is_a: GO:0031811 ! metabotropic nucleotide receptor binding

[Term]
id: GO:0031821
name: metabotropic serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a metabotropic serotonin receptor." [GOC:mah, GOC:nln]
synonym: "metabotropic 5-hydroxytryptamine receptor binding" EXACT []
synonym: "metabotropic serotonin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031822
name: type 1B serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1B serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 1B receptor binding" EXACT []
synonym: "type 1B serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! metabotropic serotonin receptor binding

[Term]
id: GO:0031823
name: type 1D serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1D serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 1D receptor binding" EXACT []
synonym: "type 1D serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! metabotropic serotonin receptor binding

[Term]
id: GO:0031824
name: type 1E serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1E serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 1E receptor binding" EXACT []
synonym: "type 1E serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! metabotropic serotonin receptor binding

[Term]
id: GO:0031825
name: type 1F serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1F serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 1F receptor binding" EXACT []
synonym: "type 1F serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! metabotropic serotonin receptor binding

[Term]
id: GO:0031826
name: type 2A serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2A serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 2A receptor binding" EXACT []
synonym: "type 2A serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! metabotropic serotonin receptor binding

[Term]
id: GO:0031827
name: type 2B serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2B serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 2B receptor binding" EXACT []
synonym: "type 2B serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! metabotropic serotonin receptor binding

[Term]
id: GO:0031828
name: type 2C serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2C serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 2C receptor binding" EXACT []
synonym: "type 2C serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! metabotropic serotonin receptor binding

[Term]
id: GO:0031829
name: type 4 serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 4 serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 4 receptor binding" EXACT []
synonym: "type 4 serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! metabotropic serotonin receptor binding

[Term]
id: GO:0031830
name: type 5A serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 5A serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 5A receptor binding" EXACT []
synonym: "type 5A serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! metabotropic serotonin receptor binding

[Term]
id: GO:0031831
name: type 5B serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 5B serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 5B receptor binding" EXACT []
synonym: "type 5B serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! metabotropic serotonin receptor binding

[Term]
id: GO:0031832
name: type 6 serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 6 serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 6 receptor binding" EXACT []
synonym: "type 6 serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! metabotropic serotonin receptor binding

[Term]
id: GO:0031833
name: type 7 serotonin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 7 serotonin receptor." [GOC:mah, GOC:nln]
synonym: "5-hydroxytryptamine 7 receptor binding" EXACT []
synonym: "type 7 serotonin receptor ligand" NARROW []
is_a: GO:0031821 ! metabotropic serotonin receptor binding

[Term]
id: GO:0031834
name: neurokinin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neurokinin receptor." [GOC:mah, GOC:nln]
synonym: "neurokinin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031835
name: substance P receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a substance P receptor." [GOC:mah, GOC:nln]
synonym: "neurokinin-1 receptor binding" EXACT []
synonym: "substance P receptor ligand" NARROW []
is_a: GO:0031834 ! neurokinin receptor binding

[Term]
id: GO:0031836
name: neuromedin K receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neuromedin K receptor." [GOC:mah, GOC:nln]
synonym: "neurokinin-B receptor binding" EXACT []
synonym: "neuromedin K receptor ligand" NARROW []
is_a: GO:0031834 ! neurokinin receptor binding

[Term]
id: GO:0031837
name: substance K receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a substance K receptor." [GOC:mah, GOC:nln]
synonym: "neurokinin-A receptor binding" EXACT []
synonym: "substance K receptor ligand" NARROW []
is_a: GO:0031834 ! neurokinin receptor binding

[Term]
id: GO:0031838
name: haptoglobin-hemoglobin complex
namespace: cellular_component
def: "A protein complex formed by the stable binding of a haptoglobin to hemoglobin." [GOC:mah]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0031839
name: type 1 neuromedin U receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 neuromedin U receptor." [GOC:mah, GOC:nln]
synonym: "type 1 neuromedin U receptor ligand" NARROW []
is_a: GO:0042922 ! neuromedin U receptor binding

[Term]
id: GO:0031840
name: type 2 neuromedin U receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 neuromedin U receptor." [GOC:mah, GOC:nln]
synonym: "type 2 neuromedin U receptor ligand" NARROW []
is_a: GO:0042922 ! neuromedin U receptor binding

[Term]
id: GO:0031841
name: neuropeptide Y receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neuropeptide Y receptor." [GOC:mah, GOC:nln]
synonym: "neuropeptide Y receptor ligand" NARROW []
synonym: "NPY receptor binding" EXACT []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031842
name: type 1 neuropeptide Y receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 neuropeptide Y receptor." [GOC:mah, GOC:nln]
synonym: "type 1 neuropeptide Y receptor ligand" NARROW []
is_a: GO:0031841 ! neuropeptide Y receptor binding

[Term]
id: GO:0031843
name: type 2 neuropeptide Y receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 neuropeptide Y receptor." [GOC:mah, GOC:nln]
synonym: "type 2 neuropeptide Y receptor ligand" NARROW []
is_a: GO:0031841 ! neuropeptide Y receptor binding

[Term]
id: GO:0031844
name: type 4 neuropeptide Y receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 4 neuropeptide Y receptor." [GOC:mah, GOC:nln]
synonym: "pancreatic polypeptide receptor binding" EXACT []
synonym: "type 4 neuropeptide Y receptor ligand" NARROW []
is_a: GO:0031841 ! neuropeptide Y receptor binding

[Term]
id: GO:0031845
name: type 5 neuropeptide Y receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 5 neuropeptide Y receptor." [GOC:mah, GOC:nln]
synonym: "type 5 neuropeptide Y receptor ligand" NARROW []
is_a: GO:0031841 ! neuropeptide Y receptor binding

[Term]
id: GO:0031846
name: neurotensin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neurotensin receptor." [GOC:mah, GOC:nln]
synonym: "neurotensin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031847
name: type 1 neurotensin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 neurotensin receptor." [GOC:mah, GOC:nln]
synonym: "type 1 neurotensin receptor ligand" NARROW []
is_a: GO:0031846 ! neurotensin receptor binding

[Term]
id: GO:0031848
name: protection from non-homologous end joining at telomere
namespace: biological_process
def: "A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse." [GOC:mah]
synonym: "protection from NHEJ-mediated telomere fusion" EXACT []
is_a: GO:0043247 ! telomere maintenance in response to DNA damage
relationship: part_of GO:0016233 ! telomere capping

[Term]
id: GO:0031849
name: olfactory receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an olfactory receptor." [GOC:mah, GOC:nln]
synonym: "olfactory receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031850
name: delta-type opioid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a delta-type opioid receptor." [GOC:mah, GOC:nln]
synonym: "delta-type opioid receptor ligand" NARROW []
is_a: GO:0031628 ! opioid receptor binding

[Term]
id: GO:0031851
name: kappa-type opioid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a kappa-type opioid receptor." [GOC:mah, GOC:nln]
synonym: "kappa-type opioid receptor ligand" NARROW []
is_a: GO:0031628 ! opioid receptor binding

[Term]
id: GO:0031852
name: mu-type opioid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mu-type opioid receptor." [GOC:mah, GOC:nln]
synonym: "mu-type opioid receptor ligand" NARROW []
is_a: GO:0031628 ! opioid receptor binding

[Term]
id: GO:0031853
name: nociceptin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nociceptin receptor." [GOC:mah, GOC:nln]
synonym: "nociceptin receptor ligand" NARROW []
is_a: GO:0031628 ! opioid receptor binding

[Term]
id: GO:0031854
name: orexigenic neuropeptide QRFP receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an orexigenic neuropeptide QRFP receptor." [GOC:mah, GOC:nln]
synonym: "orexigenic neuropeptide QRFP receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031855
name: oxytocin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an oxytocin receptor." [GOC:mah, GOC:nln]
synonym: "oxytocin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031856
name: parathyroid hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a parathyroid hormone receptor." [GOC:mah, GOC:nln]
synonym: "parathyroid hormone receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031857
name: type 1 parathyroid hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 parathyroid hormone receptor." [GOC:mah, GOC:nln]
synonym: "type 1 parathyroid hormone receptor ligand" NARROW []
is_a: GO:0031856 ! parathyroid hormone receptor binding

[Term]
id: GO:0031858
name: pituitary adenylate cyclase-activating polypeptide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pituitary adenylate cyclase-activating polypeptide receptor." [GOC:mah, GOC:nln]
synonym: "PACAP receptor binding" EXACT []
synonym: "pituitary adenylate cyclase activating peptide receptor binding" EXACT [GOC:dph, GOC:tb]
synonym: "pituitary adenylate cyclase-activating peptide receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031859
name: platelet activating factor receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a platelet activating factor receptor." [GOC:mah, GOC:nln]
synonym: "platelet activating factor receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031860
name: telomeric 3' overhang formation
namespace: biological_process
def: "The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans." [PMID:16096639]
synonym: "telomere 3'-end processing" EXACT [GOC:mah, GOC:vw]
synonym: "telomere end processing" RELATED [GOC:mah, GOC:vw]
is_a: GO:0022616 ! DNA strand elongation
relationship: part_of GO:0016233 ! telomere capping

[Term]
id: GO:0031861
name: prolactin-releasing peptide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a prolactin-releasing peptide receptor." [GOC:mah, GOC:nln]
synonym: "prolactin-releasing peptide receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031862
name: prostanoid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a prostanoid receptor." [GOC:mah, GOC:nln]
synonym: "prostanoid receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031863
name: prostaglandin D2 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a prostaglandin D2 receptor." [GOC:mah, GOC:nln]
synonym: "prostaglandin D2 receptor ligand" NARROW []
synonym: "prostanoid DP receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031864
name: EP1 subtype prostaglandin E2 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an EP1 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln]
synonym: "EP1 subtype prostaglandin E2 receptor ligand" NARROW []
synonym: "prostanoid EP1 receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031865
name: EP2 subtype prostaglandin E2 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an EP2 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln]
synonym: "EP2 subtype prostaglandin E2 receptor ligand" NARROW []
synonym: "prostanoid EP2 receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031866
name: EP3 subtype prostaglandin E2 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an EP3 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln]
synonym: "EP3 subtype prostaglandin E2 receptor ligand" NARROW []
synonym: "prostanoid EP3 receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031867
name: EP4 subtype prostaglandin E2 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an EP4 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln]
synonym: "EP4 subtype prostaglandin E2 receptor ligand" NARROW []
synonym: "prostanoid EP4 receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031868
name: prostaglandin F2-alpha receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a prostaglandin F2-alpha receptor." [GOC:mah, GOC:nln]
synonym: "prostaglandin F2-alpha receptor ligand" NARROW []
synonym: "prostanoid FP receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031869
name: prostacyclin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a prostacyclin receptor." [GOC:mah, GOC:nln]
synonym: "prostacyclin receptor ligand" NARROW []
synonym: "prostanoid IP receptor binding" EXACT []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031870
name: thromboxane A2 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a thromboxane A2 receptor." [GOC:mah, GOC:nln]
synonym: "prostanoid TP receptor binding" EXACT []
synonym: "thromboxane A2 receptor ligand" NARROW []
is_a: GO:0031862 ! prostanoid receptor binding

[Term]
id: GO:0031871
name: proteinase activated receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a proteinase activated receptor." [GOC:mah, GOC:nln]
synonym: "proteinase activated receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031872
name: type 1 proteinase activated receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 proteinase activated receptor." [GOC:mah, GOC:nln]
synonym: "thrombin receptor binding" EXACT []
synonym: "type 1 proteinase activated receptor ligand" NARROW []
is_a: GO:0031871 ! proteinase activated receptor binding

[Term]
id: GO:0031873
name: type 2 proteinase activated receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 proteinase activated receptor." [GOC:mah, GOC:nln]
synonym: "type 2 proteinase activated receptor ligand" NARROW []
is_a: GO:0031871 ! proteinase activated receptor binding

[Term]
id: GO:0031874
name: type 3 proteinase activated receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 3 proteinase activated receptor." [GOC:mah, GOC:nln]
synonym: "type 3 proteinase activated receptor ligand" NARROW []
is_a: GO:0031871 ! proteinase activated receptor binding

[Term]
id: GO:0031875
name: type 4 proteinase activated receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 4 proteinase activated receptor." [GOC:mah, GOC:nln]
synonym: "type 4 proteinase activated receptor ligand" NARROW []
is_a: GO:0031871 ! proteinase activated receptor binding

[Term]
id: GO:0031876
name: secretin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a secretin receptor." [GOC:mah, GOC:nln]
synonym: "secretin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031877
name: somatostatin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "somatostatin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031878
name: type 1 somatostatin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "type 1 somatostatin receptor ligand" NARROW []
is_a: GO:0031877 ! somatostatin receptor binding

[Term]
id: GO:0031879
name: type 2 somatostatin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "type 2 somatostatin receptor ligand" NARROW []
is_a: GO:0031877 ! somatostatin receptor binding

[Term]
id: GO:0031880
name: type 3 somatostatin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 3 somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "type 3 somatostatin receptor ligand" NARROW []
is_a: GO:0031877 ! somatostatin receptor binding

[Term]
id: GO:0031881
name: type 4 somatostatin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 4 somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "type 4 somatostatin receptor ligand" NARROW []
is_a: GO:0031877 ! somatostatin receptor binding

[Term]
id: GO:0031882
name: type 5 somatostatin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 5 somatostatin receptor." [GOC:mah, GOC:nln]
synonym: "type 5 somatostatin receptor ligand" NARROW []
is_a: GO:0031877 ! somatostatin receptor binding

[Term]
id: GO:0031883
name: taste receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a taste receptor." [GOC:mah, GOC:nln]
synonym: "taste receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031884
name: type 1 member 1 taste receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 member 1 taste receptor." [GOC:mah, GOC:nln]
synonym: "type 1 member 1 taste receptor ligand" NARROW []
is_a: GO:0031883 ! taste receptor binding

[Term]
id: GO:0031885
name: type 1 member 2 taste receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 member 2 taste receptor." [GOC:mah, GOC:nln]
synonym: "type 1 member 2 taste receptor ligand" NARROW []
is_a: GO:0031883 ! taste receptor binding

[Term]
id: GO:0031886
name: type 1 member 3 taste receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 member 3 taste receptor." [GOC:mah, GOC:nln]
synonym: "sweet taste receptor binding" EXACT []
synonym: "type 1 member 3 taste receptor ligand" NARROW []
is_a: GO:0031883 ! taste receptor binding

[Term]
id: GO:0031887
name: lipid particle transport along microtubule
namespace: biological_process
def: "The directed movement of a lipid particle along a microtubule, mediated by motor proteins." [PMID:9491895]
is_a: GO:0010970 ! microtubule-based transport

[Term]
id: GO:0031889
name: urotensin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a urotensin receptor." [GOC:mah, GOC:nln]
synonym: "urotensin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031890
name: vasoactive intestinal polypeptide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln]
synonym: "vasoactive intestinal polypeptide receptor ligand" NARROW []
synonym: "VIP receptor binding" EXACT []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031891
name: type 1 vasoactive intestinal polypeptide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln]
synonym: "type 1 vasoactive intestinal polypeptide receptor ligand" NARROW []
synonym: "type 2 PACAP receptor binding" EXACT []
is_a: GO:0031890 ! vasoactive intestinal polypeptide receptor binding

[Term]
id: GO:0031892
name: type 2 vasoactive intestinal polypeptide receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 2 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln]
synonym: "type 2 vasoactive intestinal polypeptide receptor ligand" NARROW []
synonym: "type 3 PACAP receptor binding" EXACT []
is_a: GO:0031890 ! vasoactive intestinal polypeptide receptor binding

[Term]
id: GO:0031893
name: vasopressin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a vasopressin receptor." [GOC:mah, GOC:nln]
synonym: "vasopressin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0031894
name: V1A vasopressin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a V1A vasopressin receptor." [GOC:mah, GOC:nln]
synonym: "V1A vasopressin receptor ligand" NARROW []
is_a: GO:0031893 ! vasopressin receptor binding

[Term]
id: GO:0031895
name: V1B vasopressin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a V1B vasopressin receptor." [GOC:mah, GOC:nln]
synonym: "V1B vasopressin receptor ligand" NARROW []
is_a: GO:0031893 ! vasopressin receptor binding

[Term]
id: GO:0031896
name: V2 vasopressin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a V2 vasopressin receptor." [GOC:mah, GOC:nln]
synonym: "V2 vasopressin receptor ligand" NARROW []
is_a: GO:0031893 ! vasopressin receptor binding

[Term]
id: GO:0031897
name: Tic complex
namespace: cellular_component
def: "The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane." [PMID:12180471, PMID:12393016]
synonym: "chloroplast inner membrane translocase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009706 ! chloroplast inner membrane

[Term]
id: GO:0031898
name: chromoplast envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:pz]
is_a: GO:0009526 ! plastid envelope
relationship: part_of GO:0009509 ! chromoplast

[Term]
id: GO:0031899
name: chromoplast inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma." [GOC:pz]
is_a: GO:0009528 ! plastid inner membrane
is_a: GO:0046862 ! chromoplast membrane

[Term]
id: GO:0031900
name: chromoplast outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope." [GOC:pz]
is_a: GO:0009527 ! plastid outer membrane
is_a: GO:0046862 ! chromoplast membrane

[Term]
id: GO:0031901
name: early endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an early endosome." [GOC:pz]
is_a: GO:0010008 ! endosome membrane
relationship: part_of GO:0005769 ! early endosome

[Term]
id: GO:0031902
name: late endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a late endosome." [GOC:pz]
is_a: GO:0010008 ! endosome membrane
relationship: part_of GO:0005770 ! late endosome

[Term]
id: GO:0031903
name: microbody membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a microbody." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0042579 ! microbody

[Term]
id: GO:0031904
name: endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an endosome." [GOC:mah]
xref: NIF_Subcellular:sao1547508851
is_a: GO:0044440 ! endosomal part
is_a: GO:0070013 ! intracellular organelle lumen

[Term]
id: GO:0031905
name: early endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an early endosome." [GOC:mah]
is_a: GO:0031904 ! endosome lumen
relationship: part_of GO:0005769 ! early endosome

[Term]
id: GO:0031906
name: late endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a late endosome." [GOC:mah]
is_a: GO:0031904 ! endosome lumen
relationship: part_of GO:0005770 ! late endosome

[Term]
id: GO:0031907
name: microbody lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of a microbody." [GOC:mah]
is_a: GO:0044438 ! microbody part
is_a: GO:0070013 ! intracellular organelle lumen

[Term]
id: GO:0031908
name: glyoxysomal lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of a glyoxysome." [GOC:mah]
is_a: GO:0005782 ! peroxisomal matrix

[Term]
id: GO:0031910
name: cytostome
namespace: cellular_component
def: "Stable, specialized structure for the ingestion of food by the cell into phagosomes." [PMID:10503189]
xref: Wikipedia:Cytostome
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0031911
name: cytoproct
namespace: cellular_component
def: "Stable, specialized structure for extrusion of waste by the cell into the surrounding medium." [PMID:10503189]
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0031912
name: oral apparatus
namespace: cellular_component
def: "Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems." [PMID:10503189]
comment: Note that this term refers to a subcellular structure characteristic of ciliate protozoans, and should not be confused with oral anatomical structures of multicellular animals.
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0031913
name: contractile vacuole pore
namespace: cellular_component
def: "Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium." [PMID:10503189]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044437 ! vacuolar part
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005884 ! actin filament
relationship: part_of GO:0031164 ! contractile vacuolar membrane

[Term]
id: GO:0031914
name: negative regulation of synaptic plasticity
namespace: biological_process
def: "A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah]
synonym: "down regulation of synaptic plasticity" EXACT []
synonym: "down-regulation of synaptic plasticity" EXACT []
synonym: "downregulation of synaptic plasticity" EXACT []
synonym: "inhibition of synaptic plasticity" NARROW []
is_a: GO:0048167 ! regulation of synaptic plasticity

[Term]
id: GO:0031915
name: positive regulation of synaptic plasticity
namespace: biological_process
def: "A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah]
synonym: "activation of synaptic plasticity" NARROW []
synonym: "stimulation of synaptic plasticity" NARROW []
synonym: "up regulation of synaptic plasticity" EXACT []
synonym: "up-regulation of synaptic plasticity" EXACT []
synonym: "upregulation of synaptic plasticity" EXACT []
is_a: GO:0048167 ! regulation of synaptic plasticity

[Term]
id: GO:0031916
name: regulation of synaptic metaplasticity
namespace: biological_process
def: "A process that modulates synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594]
is_a: GO:0048167 ! regulation of synaptic plasticity

[Term]
id: GO:0031917
name: negative regulation of synaptic metaplasticity
namespace: biological_process
def: "A process that decreases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594]
synonym: "down regulation of synaptic metaplasticity" EXACT []
synonym: "down-regulation of synaptic metaplasticity" EXACT []
synonym: "downregulation of synaptic metaplasticity" EXACT []
synonym: "inhibition of synaptic metaplasticity" NARROW []
is_a: GO:0031914 ! negative regulation of synaptic plasticity
is_a: GO:0031916 ! regulation of synaptic metaplasticity

[Term]
id: GO:0031918
name: positive regulation of synaptic metaplasticity
namespace: biological_process
def: "A process that increases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594]
synonym: "activation of synaptic metaplasticity" NARROW []
synonym: "stimulation of synaptic metaplasticity" NARROW []
synonym: "up regulation of synaptic metaplasticity" EXACT []
synonym: "up-regulation of synaptic metaplasticity" EXACT []
synonym: "upregulation of synaptic metaplasticity" EXACT []
is_a: GO:0031915 ! positive regulation of synaptic plasticity
is_a: GO:0031916 ! regulation of synaptic metaplasticity

[Term]
id: GO:0031919
name: vitamin B6 transport
namespace: biological_process
def: "The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0051180 ! vitamin transport

[Term]
id: GO:0031920
name: pyridoxal transport
namespace: biological_process
def: "The directed movement of pyridoxal into, out of, within or between cells by means of some external agent such as a transporter or pore. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
is_a: GO:0031919 ! vitamin B6 transport

[Term]
id: GO:0031921
name: pyridoxal phosphate transport
namespace: biological_process
def: "The directed movement of pyridoxal phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah]
is_a: GO:0031919 ! vitamin B6 transport

[Term]
id: GO:0031922
name: pyridoxamine transport
namespace: biological_process
def: "The directed movement of pyridoxamine into, out of, within or between cells by means of some external agent such as a transporter or pore. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
is_a: GO:0031919 ! vitamin B6 transport

[Term]
id: GO:0031923
name: pyridoxine transport
namespace: biological_process
def: "The directed movement of pyridoxine into, out of, within or between cells by means of some external agent such as a transporter or pore. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
is_a: GO:0031919 ! vitamin B6 transport

[Term]
id: GO:0031924
name: vitamin B6 transporter activity
namespace: molecular_function
def: "Enables the directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of, within or between cells." [GOC:mah]
is_a: GO:0051183 ! vitamin transporter activity

[Term]
id: GO:0031925
name: pyridoxal transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of pyridoxal across a membrane into, out of, within or between cells. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
synonym: "pyridoxal transporter activity" BROAD []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:0031924 ! vitamin B6 transporter activity

[Term]
id: GO:0031926
name: pyridoxal phosphate transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of pyridoxal phosphate into, out of, within or between cells; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah]
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:0031924 ! vitamin B6 transporter activity

[Term]
id: GO:0031927
name: pyridoxamine transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of pyridoxamine into, out of, within or between cells. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:0031924 ! vitamin B6 transporter activity

[Term]
id: GO:0031928
name: pyridoxine transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of pyridoxine across a membrane into, out of, within or between cells. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah]
synonym: "pyridoxine transporter activity" BROAD []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity
is_a: GO:0031924 ! vitamin B6 transporter activity

[Term]
id: GO:0031929
name: TOR signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295]
comment: Note that this term should not be confused with 'torso signaling pathway ; GO:0008293', although torso is abbreviated 'tor'.
synonym: "target of rapamycin signaling pathway" EXACT []
synonym: "target of rapamycin signalling pathway" EXACT []
synonym: "TOR signalling pathway" EXACT []
is_a: GO:0007242 ! intracellular signaling cascade

[Term]
id: GO:0031930
name: mitochondrial signaling pathway
namespace: biological_process
def: "A series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function." [GOC:jh, PMID:15068799]
synonym: "mitochondrial signalling pathway" EXACT []
synonym: "retrograde response" EXACT []
is_a: GO:0007242 ! intracellular signaling cascade

[Term]
id: GO:0031931
name: TORC1 complex
namespace: cellular_component
def: "A protein complex that contains the TOR (target of rapamycin) serine/threonine kinase and mediates temporal control of cell growth via regulation of translation, transcription, ribosome biogenesis, nutrient transport, and autophagy. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p; in mammals the complex contains orthologs of the yeast proteins." [GOC:jh, PMID:15780592]
synonym: "nutrient sensitive complex" EXACT []
synonym: "TOR complex 1" EXACT []
synonym: "TORC 1 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031932
name: TORC2 complex
namespace: cellular_component
def: "A protein complex that contains the TOR (target of rapamycin) serine/threonine kinase and mediates spatial control of cell growth via regulation of actin cytoskeleton polarization. In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p; in mammals the complex contains orthologs of the yeast proteins." [GOC:jh, PMID:14736892, PMID:15780592]
synonym: "TOR complex 2" EXACT []
synonym: "TORC 2 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0031933
name: telomeric heterochromatin
namespace: cellular_component
def: "Heterochromatic regions of the chromosome found at the telomeres." [GOC:mah]
is_a: GO:0000792 ! heterochromatin

[Term]
id: GO:0031934
name: mating-type region heterochromatin
namespace: cellular_component
def: "Heterochromatic regions of the chromosome found at silenced mating-type loci." [GOC:mah]
is_a: GO:0000792 ! heterochromatin

[Term]
id: GO:0031935
name: regulation of chromatin silencing
namespace: biological_process
def: "Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah]
synonym: "regulation of heterochromatic silencing" RELATED []
is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0060968 ! regulation of gene silencing
relationship: regulates GO:0006342 ! chromatin silencing

[Term]
id: GO:0031936
name: negative regulation of chromatin silencing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah]
synonym: "down regulation of chromatin silencing" EXACT []
synonym: "down-regulation of chromatin silencing" EXACT []
synonym: "downregulation of chromatin silencing" EXACT []
synonym: "inhibition of chromatin silencing" NARROW []
synonym: "negative regulation of heterochromatic silencing" EXACT []
is_a: GO:0031935 ! regulation of chromatin silencing
is_a: GO:0045815 ! positive regulation of gene expression, epigenetic
is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent
is_a: GO:0060969 ! negative regulation of gene silencing
relationship: negatively_regulates GO:0006342 ! chromatin silencing

[Term]
id: GO:0031937
name: positive regulation of chromatin silencing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromatin silencing." [GOC:mah]
synonym: "activation of chromatin silencing" NARROW []
synonym: "positive regulation of heterochromatic silencing" EXACT []
synonym: "stimulation of chromatin silencing" NARROW []
synonym: "up regulation of chromatin silencing" EXACT []
synonym: "up-regulation of chromatin silencing" EXACT []
synonym: "upregulation of chromatin silencing" EXACT []
is_a: GO:0031935 ! regulation of chromatin silencing
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0006342 ! chromatin silencing

[Term]
id: GO:0031938
name: regulation of chromatin silencing at telomere
namespace: biological_process
def: "Any process that affects the rate, extent or location of chromatin silencing at telomeres." [GOC:mah]
synonym: "regulation of heterochromatic silencing at telomere" EXACT []
is_a: GO:0031935 ! regulation of chromatin silencing
relationship: regulates GO:0006348 ! chromatin silencing at telomere

[Term]
id: GO:0031939
name: negative regulation of chromatin silencing at telomere
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah]
synonym: "down regulation of chromatin silencing at telomere" EXACT []
synonym: "down-regulation of chromatin silencing at telomere" EXACT []
synonym: "downregulation of chromatin silencing at telomere" EXACT []
synonym: "inhibition of chromatin silencing at telomere" NARROW []
synonym: "negative regulation of heterochromatic silencing at telomere" EXACT []
is_a: GO:0031936 ! negative regulation of chromatin silencing
is_a: GO:0031938 ! regulation of chromatin silencing at telomere
relationship: negatively_regulates GO:0006348 ! chromatin silencing at telomere

[Term]
id: GO:0031940
name: positive regulation of chromatin silencing at telomere
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah]
synonym: "activation of chromatin silencing at telomere" NARROW []
synonym: "positive regulation of heterochromatic silencing at telomere" EXACT []
synonym: "stimulation of chromatin silencing at telomere" NARROW []
synonym: "up regulation of chromatin silencing at telomere" EXACT []
synonym: "up-regulation of chromatin silencing at telomere" EXACT []
synonym: "upregulation of chromatin silencing at telomere" EXACT []
is_a: GO:0031937 ! positive regulation of chromatin silencing
is_a: GO:0031938 ! regulation of chromatin silencing at telomere
relationship: positively_regulates GO:0006348 ! chromatin silencing at telomere

[Term]
id: GO:0031941
name: filamentous actin
namespace: cellular_component
def: "A two-stranded helical polymer of the protein actin." [GOC:mah]
comment: Note that this term refers only to the actin portion of a microfilament, and does not encompass associated proteins. See also the cellular component term 'actin filament ; GO:0005884'.
synonym: "F-actin" EXACT []
xref: Wikipedia:Actin
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005884 ! actin filament

[Term]
id: GO:0031942
name: i-AAA complex
namespace: cellular_component
def: "Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases." [PMID:16247555, PMID:16267274]
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0031943
name: regulation of glucocorticoid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah]
synonym: "regulation of glucocorticoid metabolism" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
relationship: regulates GO:0008211 ! glucocorticoid metabolic process

[Term]
id: GO:0031944
name: negative regulation of glucocorticoid metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah]
synonym: "down regulation of glucocorticoid metabolic process" EXACT []
synonym: "down-regulation of glucocorticoid metabolic process" EXACT []
synonym: "downregulation of glucocorticoid metabolic process" EXACT []
synonym: "inhibition of glucocorticoid metabolic process" NARROW []
synonym: "negative regulation of glucocorticoid metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0031943 ! regulation of glucocorticoid metabolic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0045939 ! negative regulation of steroid metabolic process
relationship: negatively_regulates GO:0008211 ! glucocorticoid metabolic process

[Term]
id: GO:0031945
name: positive regulation of glucocorticoid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah]
synonym: "activation of glucocorticoid metabolic process" NARROW []
synonym: "positive regulation of glucocorticoid metabolism" EXACT []
synonym: "stimulation of glucocorticoid metabolic process" NARROW []
synonym: "up regulation of glucocorticoid metabolic process" EXACT []
synonym: "up-regulation of glucocorticoid metabolic process" EXACT []
synonym: "upregulation of glucocorticoid metabolic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0031943 ! regulation of glucocorticoid metabolic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0045940 ! positive regulation of steroid metabolic process
relationship: positively_regulates GO:0008211 ! glucocorticoid metabolic process

[Term]
id: GO:0031946
name: regulation of glucocorticoid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah]
is_a: GO:0031943 ! regulation of glucocorticoid metabolic process
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process
relationship: regulates GO:0006704 ! glucocorticoid biosynthetic process

[Term]
id: GO:0031947
name: negative regulation of glucocorticoid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah]
synonym: "down regulation of glucocorticoid biosynthetic process" EXACT []
synonym: "down-regulation of glucocorticoid biosynthetic process" EXACT []
synonym: "downregulation of glucocorticoid biosynthetic process" EXACT []
synonym: "inhibition of glucocorticoid biosynthetic process" NARROW []
is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process
is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process
is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process
relationship: negatively_regulates GO:0006704 ! glucocorticoid biosynthetic process

[Term]
id: GO:0031948
name: positive regulation of glucocorticoid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah]
synonym: "activation of glucocorticoid biosynthetic process" NARROW []
synonym: "stimulation of glucocorticoid biosynthetic process" NARROW []
synonym: "up regulation of glucocorticoid biosynthetic process" EXACT []
synonym: "up-regulation of glucocorticoid biosynthetic process" EXACT []
synonym: "upregulation of glucocorticoid biosynthetic process" EXACT []
is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process
is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process
is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process
relationship: positively_regulates GO:0006704 ! glucocorticoid biosynthetic process

[Term]
id: GO:0031949
name: regulation of glucocorticoid catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0031943 ! regulation of glucocorticoid metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
relationship: regulates GO:0006713 ! glucocorticoid catabolic process

[Term]
id: GO:0031950
name: negative regulation of glucocorticoid catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah]
synonym: "down regulation of glucocorticoid catabolic process" EXACT []
synonym: "down-regulation of glucocorticoid catabolic process" EXACT []
synonym: "downregulation of glucocorticoid catabolic process" EXACT []
synonym: "inhibition of glucocorticoid catabolic process" NARROW []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process
is_a: GO:0031949 ! regulation of glucocorticoid catabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
relationship: negatively_regulates GO:0006713 ! glucocorticoid catabolic process

[Term]
id: GO:0031951
name: positive regulation of glucocorticoid catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah]
synonym: "activation of glucocorticoid catabolic process" NARROW []
synonym: "stimulation of glucocorticoid catabolic process" NARROW []
synonym: "up regulation of glucocorticoid catabolic process" EXACT []
synonym: "up-regulation of glucocorticoid catabolic process" EXACT []
synonym: "upregulation of glucocorticoid catabolic process" EXACT []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process
is_a: GO:0031949 ! regulation of glucocorticoid catabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
relationship: positively_regulates GO:0006713 ! glucocorticoid catabolic process

[Term]
id: GO:0031952
name: regulation of protein amino acid autophosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues." [GOC:mah]
is_a: GO:0001932 ! regulation of protein amino acid phosphorylation
relationship: regulates GO:0046777 ! protein amino acid autophosphorylation

[Term]
id: GO:0031953
name: negative regulation of protein amino acid autophosphorylation
namespace: biological_process
def: "Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues." [GOC:mah]
synonym: "down regulation of protein amino acid autophosphorylation" EXACT []
synonym: "down-regulation of protein amino acid autophosphorylation" EXACT []
synonym: "downregulation of protein amino acid autophosphorylation" EXACT []
synonym: "inhibition of protein amino acid autophosphorylation" NARROW []
is_a: GO:0001933 ! negative regulation of protein amino acid phosphorylation
is_a: GO:0031952 ! regulation of protein amino acid autophosphorylation
relationship: negatively_regulates GO:0046777 ! protein amino acid autophosphorylation

[Term]
id: GO:0031954
name: positive regulation of protein amino acid autophosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues." [GOC:mah]
synonym: "activation of protein amino acid autophosphorylation" NARROW []
synonym: "stimulation of protein amino acid autophosphorylation" NARROW []
synonym: "up regulation of protein amino acid autophosphorylation" EXACT []
synonym: "up-regulation of protein amino acid autophosphorylation" EXACT []
synonym: "upregulation of protein amino acid autophosphorylation" EXACT []
is_a: GO:0001934 ! positive regulation of protein amino acid phosphorylation
is_a: GO:0031952 ! regulation of protein amino acid autophosphorylation
relationship: positively_regulates GO:0046777 ! protein amino acid autophosphorylation

[Term]
id: GO:0031955
name: short-chain-fatty-acid-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a short-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids have chain lengths of less than 8 carbons." [EC:6.2.1.3, GOC:mah]
synonym: "short-chain fatty acid activation" RELATED []
synonym: "short-chain fatty acid-CoA ligase activity" EXACT []
is_a: GO:0015645 ! fatty-acid ligase activity

[Term]
id: GO:0031956
name: medium-chain-fatty-acid-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; medium-chain fatty acids have chain lengths of C8-12." [EC:6.2.1.3, GOC:mah]
synonym: "medium-chain fatty acid activation" RELATED []
synonym: "medium-chain fatty acid-CoA ligase activity" EXACT []
is_a: GO:0015645 ! fatty-acid ligase activity

[Term]
id: GO:0031957
name: very-long-chain-fatty-acid-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; very-long-chain fatty acids have chain lengths of greater than C18." [EC:6.2.1.3, GOC:mah]
synonym: "very-long-chain fatty acid activation" RELATED []
synonym: "very-long-chain fatty acid-CoA ligase activity" EXACT []
is_a: GO:0015645 ! fatty-acid ligase activity

[Term]
id: GO:0031958
name: corticosteroid receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of a corticosteroid binding to its receptor." [GOC:mah, PMID:11027914, PMID:12606724]
synonym: "corticosteroid receptor signalling pathway" EXACT []
is_a: GO:0030518 ! steroid hormone receptor signaling pathway

[Term]
id: GO:0031959
name: mineralocorticoid receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of a mineralocorticoid binding to its receptor." [GOC:mah, PMID:11027914, PMID:12606724]
synonym: "mineralocorticoid receptor signalling pathway" EXACT []
is_a: GO:0031958 ! corticosteroid receptor signaling pathway

[Term]
id: GO:0031960
name: response to corticosteroid stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah, PMID:11027914]
is_a: GO:0048545 ! response to steroid hormone stimulus

[Term]
id: GO:0031961
name: cortisol receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cortisol receptor." [GOC:mah, PMID:12511169]
is_a: GO:0035259 ! glucocorticoid receptor binding

[Term]
id: GO:0031962
name: mineralocorticoid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mineralocorticoid receptor." [GOC:mah, PMID:12511169]
is_a: GO:0035258 ! steroid hormone receptor binding

[Term]
id: GO:0031963
name: cortisol receptor activity
namespace: molecular_function
def: "Combining with cortisol to initiate a change in cell activity." [GOC:mah, PMID:12511169]
is_a: GO:0004883 ! glucocorticoid receptor activity

[Term]
id: GO:0031964
name: beta-alanyl-histamine hydrolase activity
namespace: molecular_function
def: "Catalysis of the conversion of beta-alanyl-histamine to histamine." [GOC:rc, PMID:16299587]
synonym: "carcinine hydrolase activity" EXACT []
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0031965
name: nuclear membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz]
xref: NIF_Subcellular:sao1687101204
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0031966
name: mitochondrial membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005740 ! mitochondrial envelope

[Term]
id: GO:0031967
name: organelle envelope
namespace: cellular_component
def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz]
subset: gosubset_prok
is_a: GO:0031975 ! envelope
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0043227 ! membrane-bounded organelle

[Term]
id: GO:0031968
name: organelle outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah]
is_a: GO:0019867 ! outer membrane
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0031967 ! organelle envelope

[Term]
id: GO:0031969
name: chloroplast membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope." [GOC:mah, GOC:pz]
xref: Wikipedia:Chloroplast_membrane
is_a: GO:0042170 ! plastid membrane
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009941 ! chloroplast envelope

[Term]
id: GO:0031970
name: organelle envelope lumen
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of an organelle envelope." [GOC:mah]
synonym: "organelle intermembrane space" EXACT []
is_a: GO:0031974 ! membrane-enclosed lumen
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0031967 ! organelle envelope

[Term]
id: GO:0031972
name: chloroplast intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of a chloroplast envelope." [GOC:mah]
synonym: "chloroplast envelope lumen" EXACT []
is_a: GO:0009529 ! plastid intermembrane space
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009941 ! chloroplast envelope

[Term]
id: GO:0031973
name: chromoplast intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers of a chromoplast envelope." [GOC:mah]
synonym: "chromoplast envelope lumen" EXACT []
is_a: GO:0009529 ! plastid intermembrane space
relationship: part_of GO:0031898 ! chromoplast envelope

[Term]
id: GO:0031974
name: membrane-enclosed lumen
namespace: cellular_component
def: "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah]
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0031975
name: envelope
namespace: cellular_component
def: "A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers." [GOC:mah, GOC:pz]
subset: gosubset_prok
is_a: GO:0044464 ! cell part

[Term]
id: GO:0031976
name: plastid thylakoid
namespace: cellular_component
def: "Any thylakoid within a plastid." [GOC:pz]
is_a: GO:0009579 ! thylakoid
is_a: GO:0031984 ! organelle subcompartment
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0031977
name: thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by a thylakoid membrane." [GOC:mah, GOC:pz]
is_a: GO:0044436 ! thylakoid part
is_a: GO:0070013 ! intracellular organelle lumen

[Term]
id: GO:0031978
name: plastid thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by a plastid thylakoid membrane." [GOC:mah]
is_a: GO:0031977 ! thylakoid lumen
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0031976 ! plastid thylakoid

[Term]
id: GO:0031979
name: plasma membrane-derived thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu]
synonym: "plasma membrane thylakoid lumen" EXACT []
is_a: GO:0031977 ! thylakoid lumen
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0030075 ! plasma membrane-derived thylakoid

[Term]
id: GO:0031980
name: mitochondrial lumen
namespace: cellular_component
def: "The volume enclosed by the mitochondrial inner membrane." [GOC:mah, GOC:pz]
comment: Consider also annotating to the cellular component term 'mitochondrial matrix ; GO:0005759'.
xref: NIF_Subcellular:sao-1899375636
is_a: GO:0044429 ! mitochondrial part
is_a: GO:0070013 ! intracellular organelle lumen

[Term]
id: GO:0031981
name: nuclear lumen
namespace: cellular_component
def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz]
is_a: GO:0044428 ! nuclear part
is_a: GO:0070013 ! intracellular organelle lumen

[Term]
id: GO:0031982
name: vesicle
namespace: cellular_component
def: "Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz]
subset: goslim_pir
subset: gosubset_prok
xref: NIF_Subcellular:sao221389602
xref: Wikipedia:Vesicle_(biology)
is_a: GO:0043226 ! organelle

[Term]
id: GO:0031983
name: vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah]
xref: NIF_Subcellular:sao797538226
is_a: GO:0043233 ! organelle lumen
relationship: part_of GO:0031988 ! membrane-bounded vesicle

[Term]
id: GO:0031984
name: organelle subcompartment
namespace: cellular_component
def: "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz]
comment: Note that this term refers to membrane-bounded compartments that are not considered organelles in their own right, but form parts of larger organelles.
synonym: "suborganelle compartment" EXACT []
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0043227 ! membrane-bounded organelle

[Term]
id: GO:0031985
name: Golgi cisterna
namespace: cellular_component
def: "Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah]
is_a: GO:0031984 ! organelle subcompartment
is_a: GO:0044431 ! Golgi apparatus part
relationship: part_of GO:0005795 ! Golgi stack

[Term]
id: GO:0031986
name: proteinoplast
namespace: cellular_component
def: "A leucoplast in which protein is stored." [GOC:pz]
xref: Wikipedia:Proteinoplast
is_a: GO:0009536 ! plastid

[Term]
id: GO:0031987
name: locomotion involved in locomotory behavior
namespace: biological_process
def: "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah]
synonym: "locomotion during locomotory behaviour" EXACT []
is_a: GO:0040011 ! locomotion
relationship: part_of GO:0007626 ! locomotory behavior

[Term]
id: GO:0031988
name: membrane-bounded vesicle
namespace: cellular_component
def: "Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer." [GOC:mah]
subset: gosubset_prok
synonym: "membrane-enclosed vesicle" EXACT []
is_a: GO:0031982 ! vesicle

[Term]
id: GO:0031989
name: bombesin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a bombesin receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "bombesin receptor signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0031990
name: mRNA export from nucleus during heat stress
namespace: biological_process
def: "The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export." [GOC:mah, GOC:vw]
synonym: "mRNA export from cell nucleus during heat stress" EXACT []
is_a: GO:0006406 ! mRNA export from nucleus
is_a: GO:0034605 ! cellular response to heat

[Term]
id: GO:0031991
name: regulation of contractile ring contraction involved in cytokinesis during cell cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle." [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0032506 ! cytokinetic process
is_a: GO:0032954 ! regulation of cytokinetic process
relationship: regulates GO:0000916 ! contractile ring contraction involved in cytokinesis during cell cycle

[Term]
id: GO:0031992
name: energy transducer activity
namespace: molecular_function
def: "The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell." [GOC:go_curators]
subset: goslim_pir
synonym: "light harvesting activity" RELATED []
synonym: "photon capture" RELATED []
is_a: GO:0060089 ! molecular transducer activity

[Term]
id: GO:0031993
name: light transducer activity
namespace: molecular_function
def: "Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell." [GOC:mah, GOC:mlg]
is_a: GO:0031992 ! energy transducer activity

[Term]
id: GO:0031994
name: insulin-like growth factor I binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with insulin-like growth factor I." [GOC:mah]
synonym: "IGF-I binding" EXACT []
is_a: GO:0005520 ! insulin-like growth factor binding

[Term]
id: GO:0031995
name: insulin-like growth factor II binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with insulin-like growth factor II." [GOC:mah]
synonym: "IGF-II binding" EXACT []
is_a: GO:0005520 ! insulin-like growth factor binding

[Term]
id: GO:0031996
name: thioesterase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any thioesterase enzyme." [GOC:dl]
synonym: "thiolesterase binding" EXACT []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0031997
name: N-terminal myristoylation domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the N-terminus of a protein that has the potential to be, or has been, modified by N-terminal myristoylation. Binding affinity is typically altered by myristoylation; for example, N-terminal myristoylation of HIV Nef increases its affinity for calmodulin." [GOC:dl, GOC:jsg, PMID:15632291]
is_a: GO:0047485 ! protein N-terminus binding

[Term]
id: GO:0031998
name: regulation of fatty acid beta-oxidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation." [GOC:mah]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0046320 ! regulation of fatty acid oxidation
is_a: GO:0050994 ! regulation of lipid catabolic process
relationship: regulates GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0031999
name: negative regulation of fatty acid beta-oxidation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fatty acid beta-oxidation." [GOC:mah]
synonym: "down regulation of fatty acid beta-oxidation" EXACT []
synonym: "down-regulation of fatty acid beta-oxidation" EXACT []
synonym: "downregulation of fatty acid beta-oxidation" EXACT []
synonym: "inhibition of fatty acid beta-oxidation" NARROW []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0031998 ! regulation of fatty acid beta-oxidation
is_a: GO:0046322 ! negative regulation of fatty acid oxidation
is_a: GO:0050995 ! negative regulation of lipid catabolic process
relationship: negatively_regulates GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0032000
name: positive regulation of fatty acid beta-oxidation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation." [GOC:mah]
synonym: "activation of fatty acid beta-oxidation" NARROW []
synonym: "stimulation of fatty acid beta-oxidation" NARROW []
synonym: "up regulation of fatty acid beta-oxidation" EXACT []
synonym: "up-regulation of fatty acid beta-oxidation" EXACT []
synonym: "upregulation of fatty acid beta-oxidation" EXACT []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0031998 ! regulation of fatty acid beta-oxidation
is_a: GO:0046321 ! positive regulation of fatty acid oxidation
is_a: GO:0050996 ! positive regulation of lipid catabolic process
relationship: positively_regulates GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0032001
name: 1,4-alpha-glucan 6-alpha-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer an alpha-D-glucosyl residue in a 1,4-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a 1,4-alpha-D-glucan." [EC:2.4.1.24]
synonym: "1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT []
synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase activity" EXACT []
synonym: "D-glucosyltransferase" BROAD []
synonym: "oligoglucan-branching glycosyltransferase activity" RELATED [EC:2.4.1.24]
synonym: "T-enzyme" NARROW []
xref: EC:2.4.1.24
xref: MetaCyc:2.4.1.24-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0032002
name: interleukin-28 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-28 and interleukin-29. Composed of two subunits, IL-28R alpha and IL-10R beta." [GOC:rph]
synonym: "IL-28 receptor complex" EXACT [GOC:add]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0032003
name: interleukin-28 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-28 receptor." [GOC:rph]
synonym: "IL-28" NARROW []
synonym: "interleukin-28 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0032005
name: signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "The series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:mah]
is_a: GO:0007165 ! signal transduction
is_a: GO:0031137 ! regulation of conjugation with cellular fusion

[Term]
id: GO:0032006
name: regulation of TOR signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling via the TOR signaling pathway." [GOC:mah]
synonym: "regulation of target of rapamycin signaling pathway" EXACT []
synonym: "regulation of target of rapamycin signalling pathway" EXACT []
synonym: "regulation of TOR signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0031929 ! TOR signaling pathway

[Term]
id: GO:0032007
name: negative regulation of TOR signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the TOR signaling pathway." [GOC:mah]
synonym: "down regulation of TOR signaling pathway" EXACT []
synonym: "down-regulation of TOR signaling pathway" EXACT []
synonym: "downregulation of TOR signaling pathway" EXACT []
synonym: "inhibition of TOR signaling pathway" NARROW []
synonym: "negative regulation of target of rapamycin signaling pathway" EXACT []
synonym: "negative regulation of target of rapamycin signalling pathway" EXACT []
synonym: "negative regulation of TOR signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0032006 ! regulation of TOR signaling pathway
relationship: negatively_regulates GO:0031929 ! TOR signaling pathway

[Term]
id: GO:0032008
name: positive regulation of TOR signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling via the TOR signaling pathway." [GOC:mah]
synonym: "activation of TOR signaling pathway" NARROW []
synonym: "positive regulation of target of rapamycin signaling pathway" EXACT []
synonym: "positive regulation of target of rapamycin signalling pathway" EXACT []
synonym: "positive regulation of TOR signalling pathway" EXACT []
synonym: "stimulation of TOR signaling pathway" NARROW []
synonym: "up regulation of TOR signaling pathway" EXACT []
synonym: "up-regulation of TOR signaling pathway" EXACT []
synonym: "upregulation of TOR signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0032006 ! regulation of TOR signaling pathway
relationship: positively_regulates GO:0031929 ! TOR signaling pathway

[Term]
id: GO:0032009
name: early phagosome
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis." [GOC:mah, PMID:12388753]
synonym: "early phagocytic vesicle" EXACT []
is_a: GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0032010
name: phagolysosome
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes." [GOC:mah, PMID:12388753]
synonym: "late phagocytic vesicle" RELATED []
synonym: "late phagosome" RELATED []
xref: Wikipedia:Phagolysosome
is_a: GO:0005767 ! secondary lysosome
is_a: GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0032011
name: ARF protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state." [GOC:mah]
is_a: GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0032012
name: regulation of ARF protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]
is_a: GO:0046578 ! regulation of Ras protein signal transduction
relationship: regulates GO:0032011 ! ARF protein signal transduction

[Term]
id: GO:0032013
name: negative regulation of ARF protein signal transduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]
synonym: "down regulation of ARF protein signal transduction" EXACT []
synonym: "down-regulation of ARF protein signal transduction" EXACT []
synonym: "downregulation of ARF protein signal transduction" EXACT []
synonym: "inhibition of ARF protein signal transduction" NARROW []
is_a: GO:0032012 ! regulation of ARF protein signal transduction
is_a: GO:0046580 ! negative regulation of Ras protein signal transduction
relationship: negatively_regulates GO:0032011 ! ARF protein signal transduction

[Term]
id: GO:0032014
name: positive regulation of ARF protein signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction." [GOC:mah]
synonym: "activation of ARF protein signal transduction" NARROW []
synonym: "stimulation of ARF protein signal transduction" NARROW []
synonym: "up regulation of ARF protein signal transduction" EXACT []
synonym: "up-regulation of ARF protein signal transduction" EXACT []
synonym: "upregulation of ARF protein signal transduction" EXACT []
is_a: GO:0032012 ! regulation of ARF protein signal transduction
is_a: GO:0046579 ! positive regulation of Ras protein signal transduction
relationship: positively_regulates GO:0032011 ! ARF protein signal transduction

[Term]
id: GO:0032015
name: regulation of Ran protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Ran protein signal transduction." [GOC:mah]
is_a: GO:0046578 ! regulation of Ras protein signal transduction
relationship: regulates GO:0031291 ! Ran protein signal transduction

[Term]
id: GO:0032016
name: negative regulation of Ran protein signal transduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Ran protein signal transduction." [GOC:mah]
synonym: "down regulation of Ran protein signal transduction" EXACT []
synonym: "down-regulation of Ran protein signal transduction" EXACT []
synonym: "downregulation of Ran protein signal transduction" EXACT []
synonym: "inhibition of Ran protein signal transduction" NARROW []
is_a: GO:0032015 ! regulation of Ran protein signal transduction
is_a: GO:0046580 ! negative regulation of Ras protein signal transduction
relationship: negatively_regulates GO:0031291 ! Ran protein signal transduction

[Term]
id: GO:0032017
name: positive regulation of Ran protein signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Ran protein signal transduction." [GOC:mah]
synonym: "activation of Ran protein signal transduction" NARROW []
synonym: "stimulation of Ran protein signal transduction" NARROW []
synonym: "up regulation of Ran protein signal transduction" EXACT []
synonym: "up-regulation of Ran protein signal transduction" EXACT []
synonym: "upregulation of Ran protein signal transduction" EXACT []
is_a: GO:0032015 ! regulation of Ran protein signal transduction
is_a: GO:0046579 ! positive regulation of Ras protein signal transduction
relationship: positively_regulates GO:0031291 ! Ran protein signal transduction

[Term]
id: GO:0032018
name: 2-methylbutanal reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+." [GOC:mah, PMID:12210903]
synonym: "2-methylbutyraldehyde reductase activity" EXACT []
is_a: GO:0004032 ! aldehyde reductase activity

[Term]
id: GO:0032019
name: mitochondrial cloud
namespace: cellular_component
def: "A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material." [PMID:6541166]
synonym: "Balbiani body" EXACT []
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0032020
name: ISG15-protein conjugation
namespace: biological_process
def: "The covalent addition to a protein of ISG15, a ubiquitin-like protein." [GOC:mah]
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0032021
name: NELF complex
namespace: cellular_component
def: "A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing." [PMID:12612062]
synonym: "negative elongation factor complex" EXACT []
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0032022
name: multicellular pellicle formation
namespace: biological_process
def: "A process whereby microorganisms produce an extracellular matrix and form multicellular aggregates at an air-liquid interface." [GOC:ml]
is_a: GO:0042710 ! biofilm formation

[Term]
id: GO:0032023
name: trypsinogen activation
namespace: biological_process
def: "The proteolytic processing of trypsinogen to the active form, trypsin." [GOC:mah]
synonym: "cleavage of trypsinogen to trypsin" EXACT []
is_a: GO:0031638 ! zymogen activation

[Term]
id: GO:0032024
name: positive regulation of insulin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." [GOC:mah]
synonym: "activation of insulin secretion" NARROW []
synonym: "stimulation of insulin secretion" NARROW []
synonym: "up regulation of insulin secretion" EXACT []
synonym: "up-regulation of insulin secretion" EXACT []
synonym: "upregulation of insulin secretion" EXACT []
is_a: GO:0050796 ! regulation of insulin secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
relationship: positively_regulates GO:0030073 ! insulin secretion

[Term]
id: GO:0032025
name: response to cobalt ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus." [GOC:mah]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0032026
name: response to magnesium ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus." [GOC:mah]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0032027
name: myosin light chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a light chain of a myosin complex." [GOC:mah]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0032028
name: myosin head/neck binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the head/neck region of a myosin heavy chain." [GOC:mah]
is_a: GO:0032036 ! myosin heavy chain binding

[Term]
id: GO:0032029
name: myosin tail binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the tail region of a myosin heavy chain." [GOC:mah]
is_a: GO:0032036 ! myosin heavy chain binding

[Term]
id: GO:0032030
name: myosin I light chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a light chain of a myosin I complex." [GOC:mah]
is_a: GO:0017024 ! myosin I binding
is_a: GO:0032027 ! myosin light chain binding

[Term]
id: GO:0032031
name: myosin I head/neck binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the head/neck region of a myosin I heavy chain." [GOC:mah]
is_a: GO:0032028 ! myosin head/neck binding
is_a: GO:0032037 ! myosin I heavy chain binding

[Term]
id: GO:0032032
name: myosin I tail binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the tail region of a myosin I heavy chain." [GOC:mah]
is_a: GO:0032029 ! myosin tail binding
is_a: GO:0032037 ! myosin I heavy chain binding

[Term]
id: GO:0032033
name: myosin II light chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a light chain of a myosin II complex." [GOC:mah]
is_a: GO:0032027 ! myosin light chain binding
is_a: GO:0045159 ! myosin II binding

[Term]
id: GO:0032034
name: myosin II head/neck binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the head/neck region of a myosin II heavy chain." [GOC:mah]
is_a: GO:0032028 ! myosin head/neck binding
is_a: GO:0032038 ! myosin II heavy chain binding

[Term]
id: GO:0032035
name: myosin II tail binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the tail region of a myosin II heavy chain." [GOC:mah]
is_a: GO:0032029 ! myosin tail binding
is_a: GO:0032038 ! myosin II heavy chain binding

[Term]
id: GO:0032036
name: myosin heavy chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a heavy chain of a myosin complex." [GOC:mah]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0032037
name: myosin I heavy chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a heavy chain of a myosin I complex." [GOC:mah]
is_a: GO:0017024 ! myosin I binding
is_a: GO:0032036 ! myosin heavy chain binding

[Term]
id: GO:0032038
name: myosin II heavy chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a heavy chain of a myosin II complex." [GOC:mah]
is_a: GO:0032036 ! myosin heavy chain binding
is_a: GO:0045159 ! myosin II binding

[Term]
id: GO:0032039
name: integrator complex
namespace: cellular_component
def: "A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0032040
name: small-subunit processome
namespace: cellular_component
def: "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835]
synonym: "small subunit processome" EXACT []
synonym: "SSU processome" EXACT []
is_a: GO:0030684 ! preribosome

[Term]
id: GO:0032041
name: NAD-dependent histone deacetylase activity (H3-K14 specific)
namespace: molecular_function
def: "Catalysis of the NAD-dependent removal of an acetyl group from lysine at position 14 of the histone H3 protein." [GOC:mah]
is_a: GO:0017136 ! NAD-dependent histone deacetylase activity
is_a: GO:0031078 ! histone deacetylase activity (H3-K14 specific)

[Term]
id: GO:0032042
name: mitochondrial DNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mitochondrial DNA." [GOC:mah]
synonym: "mitochondrial DNA metabolism" EXACT []
synonym: "mtDNA metabolic process" EXACT []
synonym: "mtDNA metabolism" EXACT []
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0000002 ! mitochondrial genome maintenance

[Term]
id: GO:0032043
name: mitochondrial DNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA." [GOC:mah]
synonym: "mitochondrial DNA breakdown" EXACT []
synonym: "mitochondrial DNA catabolism" EXACT []
synonym: "mitochondrial DNA degradation" EXACT []
synonym: "mtDNA breakdown" EXACT []
synonym: "mtDNA catabolic process" EXACT []
synonym: "mtDNA catabolism" EXACT []
synonym: "mtDNA degradation" EXACT []
is_a: GO:0006308 ! DNA catabolic process
is_a: GO:0032042 ! mitochondrial DNA metabolic process

[Term]
id: GO:0032044
name: DSIF complex
namespace: cellular_component
def: "A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes." [PMID:12242279, PMID:12653964, PMID:12676794, PMID:16581788, PMID:19460865]
synonym: "5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex" EXACT []
synonym: "DRB sensitivity inducing factor complex" EXACT []
synonym: "Spt4-Spt5 complex" EXACT []
synonym: "Spt5-Spt4 complex" EXACT [GOC:vw]
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0032045
name: guanyl-nucleotide exchange factor complex
namespace: cellular_component
def: "A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase." [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0032046
name: micropexophagy-specific membrane apparatus
namespace: cellular_component
def: "A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole." [PMID:15563611]
synonym: "micropexophagic apparatus" EXACT []
synonym: "MIPA" EXACT []
is_a: GO:0031984 ! organelle subcompartment
is_a: GO:0044437 ! vacuolar part

[Term]
id: GO:0032047
name: mitosome
namespace: cellular_component
def: "A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria." [PMID:10361303, PMID:14614504]
synonym: "crypton" EXACT []
xref: Wikipedia:Mitosome
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0032048
name: cardiolipin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [ChEBI:28494, GOC:mah]
synonym: "cardiolipin metabolism" EXACT []
synonym: "diphosphatidylglycerol metabolic process" RELATED []
synonym: "diphosphatidylglycerol metabolism" RELATED []
is_a: GO:0046471 ! phosphatidylglycerol metabolic process

[Term]
id: GO:0032049
name: cardiolipin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [ChEBI:28494, GOC:mah]
synonym: "diphosphatidylglycerol biosynthesis" RELATED []
synonym: "diphosphatidylglycerol biosynthetic process" RELATED []
xref: MetaCyc:PWY-5269
is_a: GO:0006655 ! phosphatidylglycerol biosynthetic process
is_a: GO:0032048 ! cardiolipin metabolic process

[Term]
id: GO:0032050
name: clathrin heavy chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a clathrin heavy chain." [GOC:mah]
is_a: GO:0030276 ! clathrin binding

[Term]
id: GO:0032051
name: clathrin light chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a clathrin light chain." [GOC:mah]
is_a: GO:0030276 ! clathrin binding

[Term]
id: GO:0032052
name: bile acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:rph]
is_a: GO:0005496 ! steroid binding
is_a: GO:0033293 ! monocarboxylic acid binding

[Term]
id: GO:0032053
name: microtubule basal body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium or flagellum." [GOC:dph, GOC:jl, GOC:mah, PMID:9889124]
synonym: "microtubule basal body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0031023 ! microtubule organizing center organization

[Term]
id: GO:0032054
name: microtubule basal body duplication
namespace: biological_process
def: "Construction of a new microtubule basal body." [PMID:9889124]
is_a: GO:0032053 ! microtubule basal body organization

[Term]
id: GO:0032055
name: negative regulation of translation in response to stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "down regulation of translation in response to stress" EXACT []
synonym: "down-regulation of translation in response to stress" EXACT []
synonym: "downregulation of translation in response to stress" EXACT []
synonym: "inhibition of translation in response to stress" NARROW []
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0043555 ! regulation of translation in response to stress

[Term]
id: GO:0032056
name: positive regulation of translation in response to stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "activation of translation in response to stress" NARROW []
synonym: "stimulation of translation in response to stress" NARROW []
synonym: "up regulation of translation in response to stress" EXACT []
synonym: "up-regulation of translation in response to stress" EXACT []
synonym: "upregulation of translation in response to stress" EXACT []
is_a: GO:0043555 ! regulation of translation in response to stress
is_a: GO:0045727 ! positive regulation of translation

[Term]
id: GO:0032057
name: negative regulation of translational initiation in response to stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "down regulation of translation initiation in response to stress" EXACT []
synonym: "down-regulation of translation initiation in response to stress" EXACT []
synonym: "downregulation of translation initiation in response to stress" EXACT []
synonym: "inhibition of translation initiation in response to stress" NARROW []
is_a: GO:0032055 ! negative regulation of translation in response to stress
is_a: GO:0043558 ! regulation of translational initiation in response to stress
is_a: GO:0045947 ! negative regulation of translational initiation

[Term]
id: GO:0032058
name: positive regulation of translational initiation in response to stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah]
synonym: "activation of translation initiation in response to stress" NARROW []
synonym: "stimulation of translation initiation in response to stress" NARROW []
synonym: "up regulation of translation initiation in response to stress" EXACT []
synonym: "up-regulation of translation initiation in response to stress" EXACT []
synonym: "upregulation of translation initiation in response to stress" EXACT []
is_a: GO:0032056 ! positive regulation of translation in response to stress
is_a: GO:0043558 ! regulation of translational initiation in response to stress
is_a: GO:0045948 ! positive regulation of translational initiation

[Term]
id: GO:0032059
name: bleb
namespace: cellular_component
def: "A cell extension characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusions." [PMID:12083798, PMID:16624291]
subset: goslim_pir
xref: Wikipedia:Bleb_(cell_biology)
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0032060
name: bleb assembly
namespace: biological_process
def: "The assembly of a bleb, a cell extension characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusions." [PMID:12083798, PMID:16624291]
synonym: "bleb assembly" RELATED [GOC:mah]
synonym: "cell blebbing" EXACT []
is_a: GO:0030031 ! cell projection assembly

[Term]
id: GO:0032061
name: negative regulation of translation in response to osmotic stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]
synonym: "down regulation of translation in response to osmotic stress" EXACT []
synonym: "down-regulation of translation in response to osmotic stress" EXACT []
synonym: "downregulation of translation in response to osmotic stress" EXACT []
synonym: "inhibition of translation in response to osmotic stress" NARROW []
is_a: GO:0032055 ! negative regulation of translation in response to stress
is_a: GO:0043557 ! regulation of translation in response to osmotic stress

[Term]
id: GO:0032062
name: positive regulation of translation in response to osmotic stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]
synonym: "activation of translation in response to osmotic stress" NARROW []
synonym: "stimulation of translation in response to osmotic stress" NARROW []
synonym: "up regulation of translation in response to osmotic stress" EXACT []
synonym: "up-regulation of translation in response to osmotic stress" EXACT []
synonym: "upregulation of translation in response to osmotic stress" EXACT []
is_a: GO:0032056 ! positive regulation of translation in response to stress
is_a: GO:0043557 ! regulation of translation in response to osmotic stress

[Term]
id: GO:0032063
name: negative regulation of translational initiation in response to osmotic stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]
synonym: "down regulation of translation initiation in response to osmotic stress" EXACT []
synonym: "down-regulation of translation initiation in response to osmotic stress" EXACT []
synonym: "downregulation of translation initiation in response to osmotic stress" EXACT []
synonym: "inhibition of translation initiation in response to osmotic stress" NARROW []
is_a: GO:0032057 ! negative regulation of translational initiation in response to stress
is_a: GO:0032061 ! negative regulation of translation in response to osmotic stress
is_a: GO:0043561 ! regulation of translational initiation in response to osmotic stress

[Term]
id: GO:0032064
name: positive regulation of translational initiation in response to osmotic stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]
synonym: "activation of translation initiation in response to osmotic stress" NARROW []
synonym: "stimulation of translation initiation in response to osmotic stress" NARROW []
synonym: "up regulation of translation initiation in response to osmotic stress" EXACT []
synonym: "up-regulation of translation initiation in response to osmotic stress" EXACT []
synonym: "upregulation of translation initiation in response to osmotic stress" EXACT []
is_a: GO:0032058 ! positive regulation of translational initiation in response to stress
is_a: GO:0032062 ! positive regulation of translation in response to osmotic stress
is_a: GO:0043561 ! regulation of translational initiation in response to osmotic stress

[Term]
id: GO:0032065
name: cortical protein anchoring
namespace: biological_process
def: "A process by which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw]
synonym: "maintenance of protein location in cell cortex" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032507 ! maintenance of protein location in cell

[Term]
id: GO:0032066
name: nucleolus to nucleoplasm transport
namespace: biological_process
def: "The directed movement of substances from the nucleolus to the nucleoplasm." [GOC:mah]
is_a: GO:0051169 ! nuclear transport

[Term]
id: GO:0032067
name: Type IV site-specific deoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated)." [PMID:12654995]
synonym: "Type IV restriction enzyme activity" EXACT []
is_a: GO:0015666 ! restriction endodeoxyribonuclease activity

[Term]
id: GO:0032068
name: Type IV site-specific deoxyribonuclease complex
namespace: cellular_component
def: "A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation." [PMID:12654995]
synonym: "Type IV restriction enzyme complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0032069
name: regulation of nuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah]
synonym: "nuclease regulator activity" RELATED []
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0032070
name: regulation of deoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah]
synonym: "deoxyribonuclease regulator" RELATED []
synonym: "DNase regulator" RELATED []
is_a: GO:0032069 ! regulation of nuclease activity

[Term]
id: GO:0032071
name: regulation of endodeoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah]
synonym: "endodeoxyribonuclease regulator" RELATED []
is_a: GO:0032070 ! regulation of deoxyribonuclease activity

[Term]
id: GO:0032072
name: regulation of restriction endodeoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mah]
is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity

[Term]
id: GO:0032073
name: negative regulation of restriction endodeoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mah]
synonym: "down regulation of restriction endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of restriction endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of restriction endodeoxyribonuclease activity" EXACT []
synonym: "inhibition of restriction endodeoxyribonuclease activity" NARROW []
synonym: "restriction endodeoxyribonuclease inhibitor" RELATED []
synonym: "restriction enzyme inhibitor" RELATED []
is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity
is_a: GO:0032078 ! negative regulation of endodeoxyribonuclease activity

[Term]
id: GO:0032074
name: negative regulation of nuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah]
synonym: "down regulation of nuclease activity" EXACT []
synonym: "down-regulation of nuclease activity" EXACT []
synonym: "downregulation of nuclease activity" EXACT []
synonym: "inhibition of nuclease activity" NARROW []
synonym: "nuclease inhibitor" RELATED []
is_a: GO:0032069 ! regulation of nuclease activity
is_a: GO:0051346 ! negative regulation of hydrolase activity

[Term]
id: GO:0032075
name: positive regulation of nuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah]
synonym: "activation of nuclease activity" NARROW []
synonym: "nuclease activator" RELATED []
synonym: "stimulation of nuclease activity" NARROW []
synonym: "up regulation of nuclease activity" EXACT []
synonym: "up-regulation of nuclease activity" EXACT []
synonym: "upregulation of nuclease activity" EXACT []
is_a: GO:0032069 ! regulation of nuclease activity
is_a: GO:0051345 ! positive regulation of hydrolase activity

[Term]
id: GO:0032076
name: negative regulation of deoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah]
synonym: "deoxyribonuclease inhibitor" RELATED []
synonym: "DNase inhibitor" RELATED []
synonym: "down regulation of deoxyribonuclease activity" EXACT []
synonym: "down-regulation of deoxyribonuclease activity" EXACT []
synonym: "downregulation of deoxyribonuclease activity" EXACT []
synonym: "inhibition of deoxyribonuclease activity" NARROW []
is_a: GO:0032070 ! regulation of deoxyribonuclease activity
is_a: GO:0032074 ! negative regulation of nuclease activity

[Term]
id: GO:0032077
name: positive regulation of deoxyribonuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah]
synonym: "activation of deoxyribonuclease activity" NARROW []
synonym: "deoxyribonuclease activator" RELATED []
synonym: "DNase activator" RELATED []
synonym: "stimulation of deoxyribonuclease activity" NARROW []
synonym: "up regulation of deoxyribonuclease activity" EXACT []
synonym: "up-regulation of deoxyribonuclease activity" EXACT []
synonym: "upregulation of deoxyribonuclease activity" EXACT []
is_a: GO:0032070 ! regulation of deoxyribonuclease activity
is_a: GO:0032075 ! positive regulation of nuclease activity

[Term]
id: GO:0032078
name: negative regulation of endodeoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah]
synonym: "down regulation of endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of endodeoxyribonuclease activity" EXACT []
synonym: "endodeoxyribonuclease inhibitor" RELATED []
synonym: "inhibition of endodeoxyribonuclease activity" NARROW []
is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity
is_a: GO:0032076 ! negative regulation of deoxyribonuclease activity

[Term]
id: GO:0032079
name: positive regulation of endodeoxyribonuclease activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah]
synonym: "activation of endodeoxyribonuclease activity" NARROW []
synonym: "endodeoxyribonuclease activator" RELATED []
synonym: "stimulation of endodeoxyribonuclease activity" NARROW []
synonym: "up regulation of endodeoxyribonuclease activity" EXACT []
synonym: "up-regulation of endodeoxyribonuclease activity" EXACT []
synonym: "upregulation of endodeoxyribonuclease activity" EXACT []
is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity
is_a: GO:0032077 ! positive regulation of deoxyribonuclease activity

[Term]
id: GO:0032080
name: negative regulation of Type I site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of Type I restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of Type I restriction endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of Type I restriction endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of Type I restriction endodeoxyribonuclease activity" EXACT []
synonym: "inhibition of Type I restriction endodeoxyribonuclease activity" NARROW []
synonym: "negative regulation of Type I restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb]
synonym: "Type I restriction endodeoxyribonuclease inhibitor" RELATED []
synonym: "Type I restriction enzyme inhibitor" RELATED []
is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity
is_a: GO:0032084 ! regulation of Type I site-specific deoxyribonuclease activity

[Term]
id: GO:0032081
name: negative regulation of Type II site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of Type II restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of Type II restriction endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of Type II restriction endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of Type II restriction endodeoxyribonuclease activity" EXACT []
synonym: "inhibition of Type II restriction endodeoxyribonuclease activity" NARROW []
synonym: "negative regulation of Type II restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb]
synonym: "Type II restriction endodeoxyribonuclease inhibitor" RELATED []
synonym: "Type II restriction enzyme inhibitor" RELATED []
is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity
is_a: GO:0032085 ! regulation of Type II site-specific deoxyribonuclease activity

[Term]
id: GO:0032082
name: negative regulation of Type III site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of Type III restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of Type III restriction endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of Type III restriction endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of Type III restriction endodeoxyribonuclease activity" EXACT []
synonym: "inhibition of Type III restriction endodeoxyribonuclease activity" NARROW []
synonym: "negative regulation of Type III restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb]
synonym: "Type III restriction endodeoxyribonuclease inhibitor" RELATED []
synonym: "Type III restriction enzyme inhibitor" RELATED []
is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity
is_a: GO:0032086 ! regulation of Type III site-specific deoxyribonuclease activity

[Term]
id: GO:0032083
name: negative regulation of Type IV site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that stops or reduces the rate of Type IV restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of Type IV restriction endodeoxyribonuclease activity" EXACT []
synonym: "down-regulation of Type IV restriction endodeoxyribonuclease activity" EXACT []
synonym: "downregulation of Type IV restriction endodeoxyribonuclease activity" EXACT []
synonym: "inhibition of Type IV restriction endodeoxyribonuclease activity" NARROW []
synonym: "negative regulation of Type IV restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb]
synonym: "Type IV restriction endodeoxyribonuclease inhibitor" RELATED []
synonym: "Type IV restriction enzyme inhibitor" RELATED []
is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity
is_a: GO:0032087 ! regulation of Type IV site-specific deoxyribonuclease activity

[Term]
id: GO:0032084
name: regulation of Type I site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a Type I restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah]
synonym: "regulation of Type I restriction endodeoxyribonuclease activity" EXACT [GOC:dph]
synonym: "Type I restriction endodeoxyribonuclease regulator" RELATED []
synonym: "Type I restriction enzyme regulator" RELATED []
is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity

[Term]
id: GO:0032085
name: regulation of Type II site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a Type II restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah]
synonym: "regulation of Type II restriction endodeoxyribonuclease activity" EXACT [GOC:dph]
synonym: "Type II restriction endodeoxyribonuclease regulator" RELATED []
synonym: "Type II restriction enzyme regulator" RELATED []
is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity

[Term]
id: GO:0032086
name: regulation of Type III site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a Type III restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah]
synonym: "regulation of Type III restriction endoribonuclease activity" EXACT [GOC:dph]
synonym: "Type III restriction endodeoxyribonuclease regulator" RELATED []
synonym: "Type III restriction enzyme regulator" RELATED []
is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity

[Term]
id: GO:0032087
name: regulation of Type IV site-specific deoxyribonuclease activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a Type IV restriction endodeoxyribonuclease activity." [GOC:mah]
synonym: "regulation of Type IV restriction endodeoxyribonuclease activity" EXACT [GOC:dph]
synonym: "Type IV restriction endodeoxyribonuclease regulator" RELATED []
synonym: "Type IV restriction enzyme regulator" RELATED []
is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity

[Term]
id: GO:0032088
name: negative regulation of NF-kappaB transcription factor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb]
synonym: "inhibition of NF-kappaB transcription factor" EXACT [GOC:dph, GOC:tb]
synonym: "NF-kappaB inhibitor" RELATED []
is_a: GO:0043433 ! negative regulation of transcription factor activity

[Term]
id: GO:0032089
name: NACHT domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs." [GOC:rl]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0032090
name: Pyrin domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain." [GOC:rl]
synonym: "DAPIN domain binding" EXACT []
synonym: "PAAD domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0032091
name: negative regulation of protein binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein binding." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of protein binding" EXACT []
synonym: "down-regulation of protein binding" EXACT []
synonym: "downregulation of protein binding" EXACT []
synonym: "inhibition of protein binding" NARROW []
is_a: GO:0043393 ! regulation of protein binding
is_a: GO:0051100 ! negative regulation of binding

[Term]
id: GO:0032092
name: positive regulation of protein binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah]
subset: gosubset_prok
synonym: "activation of protein binding" NARROW []
synonym: "stimulation of protein binding" NARROW []
synonym: "up regulation of protein binding" EXACT []
synonym: "up-regulation of protein binding" EXACT []
synonym: "upregulation of protein binding" EXACT []
is_a: GO:0043393 ! regulation of protein binding
is_a: GO:0051099 ! positive regulation of binding

[Term]
id: GO:0032093
name: SAM domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes." [GOC:mcc, PMID:16337230]
synonym: "Sterile Alpha Motif domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0032094
name: response to food
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat." [GOC:add, ISBN:0721601464]
is_a: GO:0031667 ! response to nutrient levels
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0032095
name: regulation of response to food
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add]
is_a: GO:0032107 ! regulation of response to nutrient levels
relationship: regulates GO:0032094 ! response to food

[Term]
id: GO:0032096
name: negative regulation of response to food
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus." [GOC:add]
synonym: "down regulation of response to food" EXACT []
synonym: "down-regulation of response to food" EXACT []
synonym: "downregulation of response to food" EXACT []
synonym: "inhibition of response to food" NARROW []
is_a: GO:0032095 ! regulation of response to food
is_a: GO:0032108 ! negative regulation of response to nutrient levels
relationship: negatively_regulates GO:0032094 ! response to food

[Term]
id: GO:0032097
name: positive regulation of response to food
namespace: biological_process
def: "Any process that activates, maintains, or increases the rate of a response to a food stimulus." [GOC:add]
synonym: "activation of response to food" NARROW []
synonym: "stimulation of response to food" NARROW []
synonym: "up regulation of response to food" EXACT []
synonym: "up-regulation of response to food" EXACT []
synonym: "upregulation of response to food" EXACT []
is_a: GO:0032095 ! regulation of response to food
is_a: GO:0032109 ! positive regulation of response to nutrient levels
relationship: positively_regulates GO:0032094 ! response to food

[Term]
id: GO:0032098
name: regulation of appetite
namespace: biological_process
def: "Any process which modulates appetite, the desire or physical craving for food." [GOC:add]
synonym: "regulation of hunger" RELATED []
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0031667 ! response to nutrient levels

[Term]
id: GO:0032099
name: negative regulation of appetite
namespace: biological_process
def: "Any process that reduces appetite." [GOC:add]
synonym: "appetite suppression" RELATED []
synonym: "down regulation of appetite" EXACT []
synonym: "down-regulation of appetite" EXACT []
synonym: "downregulation of appetite" EXACT []
synonym: "inhibition of appetite" NARROW []
synonym: "negative regulation of hunger" RELATED []
is_a: GO:0032096 ! negative regulation of response to food
is_a: GO:0032098 ! regulation of appetite

[Term]
id: GO:0032100
name: positive regulation of appetite
namespace: biological_process
def: "Any process that increases appetite." [GOC:add]
synonym: "activation of appetite" NARROW []
synonym: "appetite stimulation" RELATED []
synonym: "positive regulation of hunger" RELATED []
synonym: "stimulation of appetite" NARROW []
synonym: "up regulation of appetite" EXACT []
synonym: "up-regulation of appetite" EXACT []
synonym: "upregulation of appetite" EXACT []
is_a: GO:0032097 ! positive regulation of response to food
is_a: GO:0032098 ! regulation of appetite

[Term]
id: GO:0032101
name: regulation of response to external stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0009605 ! response to external stimulus

[Term]
id: GO:0032102
name: negative regulation of response to external stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah]
synonym: "down regulation of response to external stimulus" EXACT []
synonym: "down-regulation of response to external stimulus" EXACT []
synonym: "downregulation of response to external stimulus" EXACT []
synonym: "inhibition of response to external stimulus" NARROW []
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0009605 ! response to external stimulus

[Term]
id: GO:0032103
name: positive regulation of response to external stimulus
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah]
synonym: "activation of response to external stimulus" NARROW []
synonym: "stimulation of response to external stimulus" NARROW []
synonym: "up regulation of response to external stimulus" EXACT []
synonym: "up-regulation of response to external stimulus" EXACT []
synonym: "upregulation of response to external stimulus" EXACT []
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0009605 ! response to external stimulus

[Term]
id: GO:0032104
name: regulation of response to extracellular stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah]
is_a: GO:0032101 ! regulation of response to external stimulus
relationship: regulates GO:0009991 ! response to extracellular stimulus

[Term]
id: GO:0032105
name: negative regulation of response to extracellular stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah]
synonym: "down regulation of response to extracellular stimulus" EXACT []
synonym: "down-regulation of response to extracellular stimulus" EXACT []
synonym: "downregulation of response to extracellular stimulus" EXACT []
synonym: "inhibition of response to extracellular stimulus" NARROW []
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0032104 ! regulation of response to extracellular stimulus
relationship: negatively_regulates GO:0009991 ! response to extracellular stimulus

[Term]
id: GO:0032106
name: positive regulation of response to extracellular stimulus
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of a response to an extracellular stimulus." [GOC:mah]
synonym: "activation of response to extracellular stimulus" NARROW []
synonym: "stimulation of response to extracellular stimulus" NARROW []
synonym: "up regulation of response to extracellular stimulus" EXACT []
synonym: "up-regulation of response to extracellular stimulus" EXACT []
synonym: "upregulation of response to extracellular stimulus" EXACT []
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0032104 ! regulation of response to extracellular stimulus
relationship: positively_regulates GO:0009991 ! response to extracellular stimulus

[Term]
id: GO:0032107
name: regulation of response to nutrient levels
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to nutrient levels." [GOC:mah]
is_a: GO:0032104 ! regulation of response to extracellular stimulus
relationship: regulates GO:0031667 ! response to nutrient levels

[Term]
id: GO:0032108
name: negative regulation of response to nutrient levels
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a response to nutrient levels." [GOC:mah]
synonym: "down regulation of response to nutrient levels" EXACT []
synonym: "down-regulation of response to nutrient levels" EXACT []
synonym: "downregulation of response to nutrient levels" EXACT []
synonym: "inhibition of response to nutrient levels" NARROW []
is_a: GO:0032105 ! negative regulation of response to extracellular stimulus
is_a: GO:0032107 ! regulation of response to nutrient levels
relationship: negatively_regulates GO:0031667 ! response to nutrient levels

[Term]
id: GO:0032109
name: positive regulation of response to nutrient levels
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a response to nutrient levels." [GOC:mah]
synonym: "activation of response to nutrient levels" NARROW []
synonym: "stimulation of response to nutrient levels" NARROW []
synonym: "up regulation of response to nutrient levels" EXACT []
synonym: "up-regulation of response to nutrient levels" EXACT []
synonym: "upregulation of response to nutrient levels" EXACT []
is_a: GO:0032106 ! positive regulation of response to extracellular stimulus
is_a: GO:0032107 ! regulation of response to nutrient levels
relationship: positively_regulates GO:0031667 ! response to nutrient levels

[Term]
id: GO:0032110
name: regulation of protein histidine kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein histidine kinase activity." [GOC:mah]
is_a: GO:0045859 ! regulation of protein kinase activity

[Term]
id: GO:0032111
name: activation of protein histidine kinase activity
namespace: biological_process
def: "Any process that initiates the activity of an inactive protein histidine kinase." [GOC:mah]
synonym: "protein histidine kinase activator" RELATED []
is_a: GO:0010864 ! positive regulation of protein histidine kinase activity
is_a: GO:0032147 ! activation of protein kinase activity

[Term]
id: GO:0032112
name: negative regulation of protein histidine kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein histidine kinase activity." [GOC:mah]
synonym: "down regulation of protein histidine kinase activity" EXACT []
synonym: "down-regulation of protein histidine kinase activity" EXACT []
synonym: "downregulation of protein histidine kinase activity" EXACT []
synonym: "inhibition of protein histidine kinase activity" NARROW []
synonym: "protein histidine kinase inhibitor" RELATED []
is_a: GO:0006469 ! negative regulation of protein kinase activity
is_a: GO:0032110 ! regulation of protein histidine kinase activity

[Term]
id: GO:0032113
name: regulation of carbohydrate phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of carbohydrate phosphatase activity, the catalysis of the hydrolysis of phosphate from a carbohydrate phosphate." [GOC:mah]
is_a: GO:0010921 ! regulation of phosphatase activity

[Term]
id: GO:0032114
name: regulation of glucose-6-phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucose-6-phosphatase activity, the catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate." [GOC:kp]
is_a: GO:0032113 ! regulation of carbohydrate phosphatase activity

[Term]
id: GO:0032115
name: sorbose reductase activity
namespace: molecular_function
def: "L-sorbose + NADPH + H+ = D-glucitol + NADP+. The reaction may occur, to a minor extent, in the reverse direction." [EC:1.1.11.289, GOC:mcc]
synonym: "D-glucitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.289]
synonym: "Sou1p" RELATED [EC:1.1.1.289]
xref: EC:1.1.1.289
xref: MetaCyc:1.1.1.289-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0032116
name: cohesin loading complex
namespace: cellular_component
def: "A complex required for the loading of cohesin onto DNA prior to the establishment of cohesion. Appears to be eukaryotically conserved." [GOC:vw, PMID:10882066]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032117
name: horsetail-astral microtubule array
namespace: cellular_component
def: "An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement." [GOC:mah, PMID:16111942]
synonym: "HAA" EXACT []
is_a: GO:0005818 ! aster

[Term]
id: GO:0032118
name: horsetail-astral microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the horsetail-astral array, a structure of astral microtubules that emanates from the spindle pole body during meiosis." [GOC:mah]
synonym: "horsetail-astral microtubule array organization" EXACT []
synonym: "horsetail-astral microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0032119
name: sequestering of zinc ion
namespace: biological_process
def: "The process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:mah]
is_a: GO:0051238 ! sequestering of metal ion
relationship: part_of GO:0006882 ! cellular zinc ion homeostasis

[Term]
id: GO:0032120
name: ascospore-type prospore membrane assembly
namespace: biological_process
def: "The process by which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed." [GOC:clt]
synonym: "forespore membrane biosynthesis" EXACT []
synonym: "forespore membrane formation" EXACT []
synonym: "FSM assembly" EXACT []
synonym: "FSM biosynthesis" EXACT []
synonym: "FSM formation" EXACT []
is_a: GO:0016044 ! cellular membrane organization
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0031321 ! ascospore-type prospore formation

[Term]
id: GO:0032121
name: attachment of telomeres to spindle pole body
namespace: biological_process
def: "The cell cycle process whereby physical connections are formed between telomeres and the spindle pole body, facilitating bouquet formation." [PMID:16615890]
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0045141 ! meiotic telomere clustering

[Term]
id: GO:0032122
name: oral apparatus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the oral apparatus. The oral apparatus is a funnel-like structure used by the cell to collect food and channel it to the cytostome, characteristic of ciliate protozoans." [PMID:10503189, PMID:6414830]
synonym: "oral apparatus morphogenesis" RELATED []
synonym: "oral apparatus organization and biogenesis" RELATED [GOC:mah]
synonym: "stomatogenesis" RELATED []
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0032123
name: deep fiber
namespace: cellular_component
def: "Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm." [PMID:10503189]
synonym: "deep fibre" EXACT []
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0031912 ! oral apparatus

[Term]
id: GO:0032124
name: macronucleus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the macronucleus." [GOC:dph, GOC:jl, GOC:mah, PMID:10503190]
synonym: "macronuclear organization" EXACT []
synonym: "macronuclear organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006997 ! nucleus organization

[Term]
id: GO:0032125
name: micronucleus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the micronucleus." [GOC:dph, GOC:jl, GOC:mah, PMID:10503190]
synonym: "micronuclear organization" EXACT []
synonym: "micronuclear organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006997 ! nucleus organization

[Term]
id: GO:0032126
name: eisosome
namespace: cellular_component
def: "Any of the large immobile protein assemblies at the plasma membrane that mark endocytic sites. In yeast, S. cerevisiae, these structures are primarily composed of Pil1p and Lsp1p." [PMID:16496001]
xref: Wikipedia:Eisosome
is_a: GO:0043234 ! protein complex
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0032127
name: dense core granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a dense core granule." [GOC:mah]
synonym: "dense core vesicle membrane" EXACT [GOC:kmv]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0031045 ! dense core granule

[Term]
id: GO:0032128
name: flocculation via extracellular polymer
namespace: biological_process
def: "Non-sexual aggregation of single-celled organisms mediated by polymers (polysaccharides, proteins, and/or nucleic acids) secreted into the extracellular environment." [DOI:10.1007/s002530051351, GOC:mah, PMID:14538073]
subset: gosubset_prok
synonym: "flocculation via EBF" EXACT []
synonym: "flocculation via extracellular biopolymeric flocculants" EXACT []
is_a: GO:0000128 ! flocculation

[Term]
id: GO:0032129
name: histone deacetylase activity (H3-K9 specific)
namespace: molecular_function
def: "Catalysis of the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [GOC:mah]
is_a: GO:0004407 ! histone deacetylase activity

[Term]
id: GO:0032130
name: medial membrane band assembly
namespace: biological_process
def: "The assembly of a sterol-rich region of the plasma membrane at the cell surface overlying the contractile ring." [PMID:15517003]
synonym: "medial membrane band formation" RELATED [gOC:dph]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0033205 ! cytokinesis during cell cycle

[Term]
id: GO:0032131
name: alkylated DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with alkylated residues in DNA." [GOC:mah]
is_a: GO:0003684 ! damaged DNA binding

[Term]
id: GO:0032132
name: O6-alkylguanine-DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with O6-alkylguanine adducts in DNA." [GOC:mah, PMID:16679453]
is_a: GO:0032131 ! alkylated DNA binding

[Term]
id: GO:0032133
name: chromosome passenger complex
namespace: cellular_component
def: "A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin." [GOC:vw, PMID:16824200, PMID:19570910]
synonym: "chromosomal passenger complex" EXACT [GOC:mcc]
is_a: GO:0005875 ! microtubule associated complex

[Term]
id: GO:0032134
name: mispaired DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing pyrimidine/purine mispairs." [GOC:vk]
synonym: "mispair binding" EXACT []
is_a: GO:0030983 ! mismatched DNA binding

[Term]
id: GO:0032135
name: DNA insertion or deletion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing insertions or deletions." [GOC:vk]
synonym: "DNA insertion binding" NARROW []
synonym: "insertion binding" EXACT []
is_a: GO:0030983 ! mismatched DNA binding

[Term]
id: GO:0032136
name: adenine/cytosine mispair binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing an A/C mispair." [GOC:vk]
synonym: "A/C mispair binding" EXACT []
is_a: GO:0032134 ! mispaired DNA binding

[Term]
id: GO:0032137
name: guanine/thymine mispair binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a G/T mispair." [GOC:vk]
synonym: "G/T mispair binding" EXACT []
is_a: GO:0032134 ! mispaired DNA binding

[Term]
id: GO:0032138
name: single base insertion or deletion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a single base insertion or deletion." [GOC:vk]
synonym: "single base insertion binding" NARROW []
is_a: GO:0032135 ! DNA insertion or deletion binding

[Term]
id: GO:0032139
name: dinucleotide insertion or deletion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide insertion or deletion." [GOC:vk]
synonym: "dinucleotide insertion binding" NARROW []
is_a: GO:0032135 ! DNA insertion or deletion binding

[Term]
id: GO:0032140
name: single adenine insertion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a single adenine insertion or a deletion that results in an unpaired adenine." [GOC:mah, GOC:vk]
is_a: GO:0032138 ! single base insertion or deletion binding

[Term]
id: GO:0032141
name: single cytosine insertion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a single cytosine insertion or a deletion that results in an unpaired cytosine." [GOC:mah, GOC:vk]
is_a: GO:0032138 ! single base insertion or deletion binding

[Term]
id: GO:0032142
name: single guanine insertion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a single guanine insertion or a deletion that results in an unpaired guanine." [GOC:mah, GOC:vk]
is_a: GO:0032138 ! single base insertion or deletion binding

[Term]
id: GO:0032143
name: single thymine insertion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a single thymine insertion or a deletion that results in an unpaired thymine." [GOC:mah, GOC:vk]
is_a: GO:0032138 ! single base insertion or deletion binding

[Term]
id: GO:0032144
name: 4-aminobutyrate transaminase complex
namespace: cellular_component
def: "A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity." [GOC:mah, PMID:15528998]
synonym: "ABAT complex" EXACT []
synonym: "GABA transaminase complex" EXACT []
synonym: "GABA-T complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0032145
name: succinate-semialdehyde dehydrogenase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with succinate-semialdehyde dehydrogenase." [GOC:mah]
synonym: "succinic semialdehyde dehydrogenase binding" EXACT []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0032146
name: thiosulfate transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in)." [GOC:mlg]
is_a: GO:0015117 ! thiosulfate transmembrane transporter activity
is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity

[Term]
id: GO:0032147
name: activation of protein kinase activity
namespace: biological_process
def: "Any process that initiates the activity of an inactive protein kinase." [GOC:mah]
synonym: "protein kinase activation" RELATED []
is_a: GO:0045860 ! positive regulation of protein kinase activity

[Term]
id: GO:0032148
name: activation of protein kinase B activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme protein kinase B." [GOC:pg]
synonym: "protein kinase B activation" EXACT []
is_a: GO:0032147 ! activation of protein kinase activity

[Term]
id: GO:0032149
name: response to rhamnose stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus." [GOC:mlg]
synonym: "response to L-rhamnose stimulus" NARROW []
is_a: GO:0009746 ! response to hexose stimulus

[Term]
id: GO:0032150
name: ubiquinone biosynthetic process from chorismate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of chorismate to 4-hydroxybenzoate." [GOC:mah, PMID:11583838]
is_a: GO:0006744 ! ubiquinone biosynthetic process

[Term]
id: GO:0032151
name: mitotic septin complex
namespace: cellular_component
def: "A heterooligomeric septin complex that acts during mitotic cell division." [GOC:krc, PMID:16009555]
is_a: GO:0031105 ! septin complex

[Term]
id: GO:0032152
name: meiotic septin complex
namespace: cellular_component
def: "A heterooligomeric septin complex that acts during meiotic cell division." [GOC:krc, PMID:16009555]
is_a: GO:0031105 ! septin complex

[Term]
id: GO:0032153
name: cell division site
namespace: cellular_component
def: "The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. The cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane. The mitotic, or meiotic, spindle is aligned perpendicular to the division plane." [GOC:krc, GOC:ns, PMID:12101122, PMID:15380095]
subset: goslim_pir
synonym: "cell division plane" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0032154
name: cleavage furrow
namespace: cellular_component
def: "In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists." [ISBN:0805319409]
xref: Wikipedia:Cleavage_furrow
is_a: GO:0032155 ! cell division site part

[Term]
id: GO:0032155
name: cell division site part
namespace: cellular_component
def: "Any constituent part of the cell division plane, the eventual plane of cell division in a dividing cell." [GOC:mah]
synonym: "cell division plane part" EXACT []
is_a: GO:0044464 ! cell part
relationship: part_of GO:0032153 ! cell division site

[Term]
id: GO:0032156
name: septin cytoskeleton
namespace: cellular_component
def: "The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes." [GOC:mah]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0032157
name: prospore contractile ring
namespace: cellular_component
def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis." [GOC:krc, PMID:16009555]
synonym: "actomyosin ring" BROAD []
synonym: "cytokinetic ring" BROAD []
synonym: "meiotic contractile ring" RELATED []
is_a: GO:0005826 ! actomyosin contractile ring
relationship: part_of GO:0042764 ! ascospore-type prospore

[Term]
id: GO:0032158
name: septin band
namespace: cellular_component
def: "A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, PMID:16151244]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0032156 ! septin cytoskeleton

[Term]
id: GO:0032159
name: septin cap
namespace: cellular_component
def: "A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244]
is_a: GO:0032156 ! septin cytoskeleton
is_a: GO:0044430 ! cytoskeletal part

[Term]
id: GO:0032160
name: septin filament array
namespace: cellular_component
def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans." [GOC:krc, PMID:16151244]
synonym: "septin bar" RELATED []
is_a: GO:0032156 ! septin cytoskeleton
is_a: GO:0044430 ! cytoskeletal part

[Term]
id: GO:0032161
name: cleavage apparatus septin structure
namespace: cellular_component
def: "Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis." [GOC:krc, PMID:12101122, PMID:15774761, PMID:16009555]
is_a: GO:0032155 ! cell division site part
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0032156 ! septin cytoskeleton

[Term]
id: GO:0032162
name: mating projection septin band
namespace: cellular_component
def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the neck of a shmoo (mating projection)." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0032158 ! septin band

[Term]
id: GO:0032163
name: hyphal septin band
namespace: cellular_component
def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0032158 ! septin band

[Term]
id: GO:0032164
name: hyphal septin cap
namespace: cellular_component
def: "A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244]
is_a: GO:0032159 ! septin cap

[Term]
id: GO:0032165
name: prospore septin filament array
namespace: cellular_component
def: "Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation." [GOC:krc, PMID:16151244]
is_a: GO:0032160 ! septin filament array

[Term]
id: GO:0032166
name: chlamydospore septin filament array
namespace: cellular_component
def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation." [GOC:krc, PMID:16151244]
is_a: GO:0032160 ! septin filament array

[Term]
id: GO:0032167
name: septin patch
namespace: cellular_component
def: "OBSOLETE. An amorphous-appearing accumulation of septin proteins at the future site of cytokinesis." [PMID:16009555]
comment: This term was made obsolete because it was added in error; it does not refer to a normal subcellular structure.
is_obsolete: true

[Term]
id: GO:0032168
name: hyphal septin ring
namespace: cellular_component
def: "A tight ring-shaped structure that forms in the division plane within hyphae of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0005940 ! septin ring

[Term]
id: GO:0032169
name: prospore septin ring
namespace: cellular_component
def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0005940 ! septin ring
is_a: GO:0032161 ! cleavage apparatus septin structure
relationship: part_of GO:0042764 ! ascospore-type prospore

[Term]
id: GO:0032170
name: pseudohyphal septin ring
namespace: cellular_component
def: "A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0005940 ! septin ring

[Term]
id: GO:0032171
name: germ tube septin cap
namespace: cellular_component
def: "A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244]
is_a: GO:0032159 ! septin cap

[Term]
id: GO:0032172
name: germ tube septin ring
namespace: cellular_component
def: "A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, PMID:16151244]
is_a: GO:0005940 ! septin ring
relationship: part_of GO:0032179 ! germ tube

[Term]
id: GO:0032173
name: septin collar
namespace: cellular_component
def: "A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell." [GOC:krc, PMID:16009555, PMID:16151244]
is_a: GO:0032156 ! septin cytoskeleton
is_a: GO:0044430 ! cytoskeletal part

[Term]
id: GO:0032174
name: cellular bud neck septin collar
namespace: cellular_component
def: "A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck." [GOC:krc, PMID:16009555]
is_a: GO:0000399 ! cellular bud neck septin structure
is_a: GO:0032161 ! cleavage apparatus septin structure
is_a: GO:0032173 ! septin collar

[Term]
id: GO:0032175
name: mating projection septin ring
namespace: cellular_component
def: "A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip." [GOC:krc, GOC:mah, PMID:16151244]
is_a: GO:0005940 ! septin ring

[Term]
id: GO:0032176
name: split septin rings
namespace: cellular_component
def: "A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well." [GOC:krc, PMID:16009555, PMID:16151244]
is_a: GO:0032156 ! septin cytoskeleton
is_a: GO:0044430 ! cytoskeletal part

[Term]
id: GO:0032177
name: cellular bud neck split septin rings
namespace: cellular_component
def: "Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated." [GOC:krc, PMID:16009555]
is_a: GO:0000399 ! cellular bud neck septin structure
is_a: GO:0032161 ! cleavage apparatus septin structure
is_a: GO:0032176 ! split septin rings

[Term]
id: GO:0032178
name: medial membrane band
namespace: cellular_component
def: "A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum." [PMID:15517003]
synonym: "sterol-rich membrane band" RELATED []
is_a: GO:0032155 ! cell division site part
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0032179
name: germ tube
namespace: cellular_component
def: "The slender tubular outgrowth first produced by most spores in germination." [ISBN:0877799148]
subset: goslim_pir
xref: Wikipedia:Germ_tube
is_a: GO:0044464 ! cell part

[Term]
id: GO:0032180
name: ubiquinone biosynthetic process from tyrosine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of tyrosine to 4-hydroxybenzoate." [GOC:mah, PMID:11583838]
is_a: GO:0006744 ! ubiquinone biosynthetic process

[Term]
id: GO:0032181
name: dinucleotide repeat insertion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats." [GOC:mah, GOC:vk]
is_a: GO:0032139 ! dinucleotide insertion or deletion binding

[Term]
id: GO:0032182
name: small conjugating protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein." [GOC:mah]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0032183
name: SUMO binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO." [GOC:mah]
synonym: "Smt3 binding" RELATED []
synonym: "Smt3 monomer binding" NARROW []
is_a: GO:0032182 ! small conjugating protein binding

[Term]
id: GO:0032184
name: SUMO polymer binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a polymer of the small ubiquitin-like protein SUMO." [GOC:mah]
synonym: "Smt3 polymer binding" EXACT []
is_a: GO:0032183 ! SUMO binding

[Term]
id: GO:0032185
name: septin cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]
subset: gosubset_prok
synonym: "septin cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0032186
name: cellular bud neck septin ring organization
namespace: biological_process
def: "Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck." [GOC:mah]
is_a: GO:0031106 ! septin ring organization
is_a: GO:0032506 ! cytokinetic process
relationship: part_of GO:0010687 ! cytokinesis during cell cycle, site selection

[Term]
id: GO:0032187
name: contractile ring localization involved in cytokinesis during cell cycle
namespace: biological_process
def: "The process by which a contractile ring is assembled and/or maintained in a specific location, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:mah]
is_a: GO:0032506 ! cytokinetic process
is_a: GO:0051641 ! cellular localization
relationship: part_of GO:0033205 ! cytokinesis during cell cycle

[Term]
id: GO:0032188
name: establishment of contractile ring localization involved in cytokinesis during cell cycle
namespace: biological_process
def: "The process by which a contractile ring is assembled in a specific location." [GOC:mah]
is_a: GO:0032187 ! contractile ring localization involved in cytokinesis during cell cycle
relationship: part_of GO:0007105 ! cytokinesis, site selection

[Term]
id: GO:0032189
name: maintenance of contractile ring localization involved in cytokinesis during cell cycle
namespace: biological_process
def: "Any process by which a contractile ring is maintained in a location and prevented from moving elsewhere." [GOC:mah]
synonym: "cytokinetic ring anchoring" RELATED []
is_a: GO:0032187 ! contractile ring localization involved in cytokinesis during cell cycle
relationship: part_of GO:0031566 ! contractile ring maintenance involved in cytokinesis during cell cycle

[Term]
id: GO:0032190
name: acrosin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities." [GOC:mah, PMID:12398221]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0032191
name: acrosin heavy chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the larger of the two covalently linked polypeptide chains of acrosin." [GOC:mah, PMID:12398221]
is_a: GO:0032190 ! acrosin binding

[Term]
id: GO:0032192
name: acrosin light chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the smaller of the two covalently linked polypeptide chains of acrosin." [GOC:mah, PMID:12398221]
is_a: GO:0032190 ! acrosin binding

[Term]
id: GO:0032193
name: ubiquinone biosynthetic process via 2-polyprenylphenol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 2-polyprenylphenol and 2-polyprenyl-6-hydroxyphenol." [GOC:mah, PMID:11583838]
is_a: GO:0006744 ! ubiquinone biosynthetic process

[Term]
id: GO:0032194
name: ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 3,4-dihydroxy-5-polyprenylbenzoate and 3-methoxy-4-hydroxy-5-polyprenylbenzoate." [GOC:mah, PMID:11583838]
is_a: GO:0006744 ! ubiquinone biosynthetic process

[Term]
id: GO:0032195
name: post-lysosomal vacuole
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis." [GOC:pf, PMID:9276759, PMID:9394012]
is_a: GO:0005773 ! vacuole
is_a: GO:0030139 ! endocytic vesicle

[Term]
id: GO:0032196
name: transposition
namespace: biological_process
def: "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites." [GOC:jp, ISBN:1555812090]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
xref: Wikipedia:Transposon
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0032197
name: transposition, RNA-mediated
namespace: biological_process
alt_id: GO:0006319
alt_id: GO:0006320
alt_id: GO:0006321
alt_id: GO:0006322
def: "Any process involved in a type of transpositional recombination which occurs via an RNA intermediate." [GOC:jp, ISBN:1555812090]
subset: gosubset_prok
synonym: "Class I transposition" EXACT []
synonym: "retrotransposition" EXACT []
synonym: "retrotransposon transposition" EXACT []
synonym: "Tf transposition" NARROW []
synonym: "Ty element transposition" NARROW []
synonym: "Ty1 element transposition" NARROW []
synonym: "Ty2 element transposition" NARROW []
synonym: "Ty3 element transposition" NARROW []
xref: Wikipedia:Transposon##Class_I\:_Retrotransposons
is_a: GO:0032196 ! transposition

[Term]
id: GO:0032198
name: MITE transposition
namespace: biological_process
def: "Any process involved in the transposition of miniature inverted-repeat transposable elements (MITEs)." [GOC:jp, ISBN:1555812090]
synonym: "Class III transposition" EXACT []
is_a: GO:0032196 ! transposition

[Term]
id: GO:0032199
name: transcription during RNA-mediated transposition
namespace: biological_process
def: "The synthesis of DNA from an RNA transposon intermediate." [GOC:jp, ISBN:1555812090]
synonym: "reverse transcription during retrotransposition" EXACT []
is_a: GO:0032197 ! transposition, RNA-mediated
relationship: part_of GO:0006410 ! transcription, RNA-dependent

[Term]
id: GO:0032200
name: telomere organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah]
synonym: "chromosome organization, telomeric" EXACT []
synonym: "organization of chromosome, telomeric region" EXACT []
synonym: "telomere organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0032201
name: telomere maintenance via semi-conservative replication
namespace: biological_process
def: "The process whereby telomeric DNA is synthesized semi-conservatively by the conventional replication machinery and telomeric accessory factors." [GOC:vw, PMID:16598261]
synonym: "equal telomere replication" RELATED []
synonym: "telomeric fork progression" NARROW []
synonym: "telomeric replication fork progression" NARROW []
xref: Reactome:174417 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:449043 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:470157 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:487978 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:507819 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:517822 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:526653 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:531373 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:536824 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:542498 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:547825 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:552393 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:558092 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:568649 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:581853 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:585974 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:592830 "Telomere C-strand (Lagging Strand) Synthesis"
xref: Reactome:595552 "Telomere C-strand (Lagging Strand) Synthesis"
is_a: GO:0006261 ! DNA-dependent DNA replication
is_a: GO:0010833 ! telomere maintenance via telomere lengthening

[Term]
id: GO:0032202
name: telomere assembly
namespace: biological_process
def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a telomere at a non-telomeric double-stranded DNA end. A telomere is a terminal region of a linear chromosome that includes telomeric DNA repeats and associated proteins." [GOC:mah, GOC:ns, PMID:11902675, PMID:8622671]
synonym: "telomere formation" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0032200 ! telomere organization

[Term]
id: GO:0032203
name: telomere formation via telomerase
namespace: biological_process
def: "The addition of telomeric repeats to a non-telomeric double-stranded DNA end by telomerase." [GOC:ns, PMID:11902675, PMID:8622671]
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0032202 ! telomere assembly

[Term]
id: GO:0032204
name: regulation of telomere maintenance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0000723 ! telomere maintenance

[Term]
id: GO:0032205
name: negative regulation of telomere maintenance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]
synonym: "down regulation of telomere maintenance" EXACT []
synonym: "down-regulation of telomere maintenance" EXACT []
synonym: "downregulation of telomere maintenance" EXACT []
synonym: "inhibition of telomere maintenance" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0032204 ! regulation of telomere maintenance
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0051053 ! negative regulation of DNA metabolic process
relationship: negatively_regulates GO:0000723 ! telomere maintenance

[Term]
id: GO:0032206
name: positive regulation of telomere maintenance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah]
synonym: "activation of telomere maintenance" NARROW []
synonym: "stimulation of telomere maintenance" NARROW []
synonym: "up regulation of telomere maintenance" EXACT []
synonym: "up-regulation of telomere maintenance" EXACT []
synonym: "upregulation of telomere maintenance" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0032204 ! regulation of telomere maintenance
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0051054 ! positive regulation of DNA metabolic process
relationship: positively_regulates GO:0000723 ! telomere maintenance

[Term]
id: GO:0032207
name: regulation of telomere maintenance via recombination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah]
is_a: GO:0000019 ! regulation of mitotic recombination
is_a: GO:0032204 ! regulation of telomere maintenance
relationship: regulates GO:0000722 ! telomere maintenance via recombination

[Term]
id: GO:0032208
name: negative regulation of telomere maintenance via recombination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah]
synonym: "down regulation of telomere maintenance via recombination" EXACT []
synonym: "down-regulation of telomere maintenance via recombination" EXACT []
synonym: "downregulation of telomere maintenance via recombination" EXACT []
synonym: "inhibition of telomere maintenance via recombination" NARROW []
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:0032207 ! regulation of telomere maintenance via recombination
is_a: GO:0045950 ! negative regulation of mitotic recombination
relationship: negatively_regulates GO:0000722 ! telomere maintenance via recombination

[Term]
id: GO:0032209
name: positive regulation of telomere maintenance via recombination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah]
synonym: "activation of telomere maintenance via recombination" NARROW []
synonym: "stimulation of telomere maintenance via recombination" NARROW []
synonym: "up regulation of telomere maintenance via recombination" EXACT []
synonym: "up-regulation of telomere maintenance via recombination" EXACT []
synonym: "upregulation of telomere maintenance via recombination" EXACT []
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:0032207 ! regulation of telomere maintenance via recombination
is_a: GO:0045951 ! positive regulation of mitotic recombination
relationship: positively_regulates GO:0000722 ! telomere maintenance via recombination

[Term]
id: GO:0032210
name: regulation of telomere maintenance via telomerase
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]
is_a: GO:0006275 ! regulation of DNA replication
is_a: GO:0032204 ! regulation of telomere maintenance
relationship: regulates GO:0007004 ! telomere maintenance via telomerase

[Term]
id: GO:0032211
name: negative regulation of telomere maintenance via telomerase
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]
synonym: "down regulation of telomere maintenance via telomerase activity" EXACT []
synonym: "down-regulation of telomere maintenance via telomerase activity" EXACT []
synonym: "downregulation of telomere maintenance via telomerase activity" EXACT []
synonym: "inhibition of telomere maintenance via telomerase" NARROW []
is_a: GO:0008156 ! negative regulation of DNA replication
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:0032210 ! regulation of telomere maintenance via telomerase
relationship: negatively_regulates GO:0007004 ! telomere maintenance via telomerase

[Term]
id: GO:0032212
name: positive regulation of telomere maintenance via telomerase
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah]
synonym: "activation of telomere maintenance via telomerase" NARROW []
synonym: "stimulation of telomere maintenance via telomerase" NARROW []
synonym: "up regulation of telomere maintenance via telomerase activity" EXACT []
synonym: "up-regulation of telomere maintenance via telomerase activity" EXACT []
synonym: "upregulation of telomere maintenance via telomerase activity" EXACT []
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:0032210 ! regulation of telomere maintenance via telomerase
is_a: GO:0045740 ! positive regulation of DNA replication
relationship: positively_regulates GO:0007004 ! telomere maintenance via telomerase

[Term]
id: GO:0032213
name: regulation of telomere maintenance via semi-conservative replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah]
is_a: GO:0006275 ! regulation of DNA replication
is_a: GO:0032204 ! regulation of telomere maintenance
relationship: regulates GO:0032201 ! telomere maintenance via semi-conservative replication

[Term]
id: GO:0032214
name: negative regulation of telomere maintenance via semi-conservative replication
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah]
synonym: "down regulation of telomere maintenance via semi-conservative replication" EXACT []
synonym: "down-regulation of telomere maintenance via semi-conservative replication" EXACT []
synonym: "downregulation of telomere maintenance via semi-conservative replication" EXACT []
synonym: "inhibition of telomere maintenance via semi-conservative replication" NARROW []
is_a: GO:0008156 ! negative regulation of DNA replication
is_a: GO:0032205 ! negative regulation of telomere maintenance
is_a: GO:0032213 ! regulation of telomere maintenance via semi-conservative replication
relationship: negatively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication

[Term]
id: GO:0032215
name: positive regulation of telomere maintenance via semi-conservative replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah]
synonym: "activation of telomere maintenance via semi-conservative replication" NARROW []
synonym: "stimulation of telomere maintenance via semi-conservative replication" NARROW []
synonym: "up regulation of telomere maintenance via semi-conservative replication" EXACT []
synonym: "up-regulation of telomere maintenance via semi-conservative replication" EXACT []
synonym: "upregulation of telomere maintenance via semi-conservative replication" EXACT []
is_a: GO:0032206 ! positive regulation of telomere maintenance
is_a: GO:0032213 ! regulation of telomere maintenance via semi-conservative replication
is_a: GO:0045740 ! positive regulation of DNA replication
relationship: positively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication

[Term]
id: GO:0032216
name: glucosaminyl-phosphotidylinositol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucosaminyl-phosphotidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phosphotidylinositol + CoA." [Reactome:REACT_1049.1]
synonym: "GPI-inositol acyltransferase" RELATED []
xref: EC:2.3.1.-
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0032217
name: riboflavin transporter activity
namespace: molecular_function
def: "Facilitates the directed movement of riboflavin into, out of, within or between cells. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239]
is_a: GO:0051183 ! vitamin transporter activity

[Term]
id: GO:0032218
name: riboflavin transport
namespace: biological_process
def: "The directed movement of riboflavin into, out of, within or between cells by means of some external agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239]
is_a: GO:0051180 ! vitamin transport

[Term]
id: GO:0032219
name: cell wall macromolecule catabolic process during cytogamy
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of macromolecules forming part of a cell wall during cytogamy." [GOC:mah]
is_a: GO:0044039 ! cellular cell wall macromolecule catabolic process
relationship: part_of GO:0000755 ! cytogamy

[Term]
id: GO:0032220
name: plasma membrane fusion during cytogamy
namespace: biological_process
def: "The joining of two or more lipid bilayer membranes that surround cells, during cytogamy." [GOC:mah]
is_a: GO:0045026 ! plasma membrane fusion
relationship: part_of GO:0000755 ! cytogamy

[Term]
id: GO:0032221
name: Rpd3S complex
namespace: cellular_component
alt_id: GO:0000509
def: "A eukaryotically conserved histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species)." [GOC:vw, PMID:12773392, PMID:17450151]
synonym: "Clr6 histone deacetylase complex II'" EXACT [GOC:vw]
synonym: "Clr6S complex" EXACT [PMID:19040720]
synonym: "Rpd3C(S)" EXACT []
is_a: GO:0070822 ! Sin3-type complex

[Term]
id: GO:0032222
name: regulation of synaptic transmission, cholinergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
is_a: GO:0050804 ! regulation of synaptic transmission
relationship: regulates GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0032223
name: negative regulation of synaptic transmission, cholinergic
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
synonym: "down regulation of synaptic transmission, cholinergic" EXACT []
synonym: "down-regulation of synaptic transmission, cholinergic" EXACT []
synonym: "downregulation of synaptic transmission, cholinergic" EXACT []
synonym: "inhibition of synaptic transmission, cholinergic" NARROW []
is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic
is_a: GO:0050805 ! negative regulation of synaptic transmission
relationship: negatively_regulates GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0032224
name: positive regulation of synaptic transmission, cholinergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah]
synonym: "activation of synaptic transmission, cholinergic" NARROW []
synonym: "stimulation of synaptic transmission, cholinergic" NARROW []
synonym: "up regulation of synaptic transmission, cholinergic" EXACT []
synonym: "up-regulation of synaptic transmission, cholinergic" EXACT []
synonym: "upregulation of synaptic transmission, cholinergic" EXACT []
is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic
is_a: GO:0050806 ! positive regulation of synaptic transmission
relationship: positively_regulates GO:0007271 ! synaptic transmission, cholinergic

[Term]
id: GO:0032225
name: regulation of synaptic transmission, dopaminergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah]
is_a: GO:0050804 ! regulation of synaptic transmission
relationship: regulates GO:0001963 ! synaptic transmission, dopaminergic

[Term]
id: GO:0032226
name: positive regulation of synaptic transmission, dopaminergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah]
synonym: "activation of synaptic transmission, dopaminergic" NARROW []
synonym: "stimulation of synaptic transmission, dopaminergic" NARROW []
synonym: "up regulation of synaptic transmission, dopaminergic" EXACT []
synonym: "up-regulation of synaptic transmission, dopaminergic" EXACT []
synonym: "upregulation of synaptic transmission, dopaminergic" EXACT []
is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic
is_a: GO:0050806 ! positive regulation of synaptic transmission
relationship: positively_regulates GO:0001963 ! synaptic transmission, dopaminergic

[Term]
id: GO:0032227
name: negative regulation of synaptic transmission, dopaminergic
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah]
synonym: "down regulation of synaptic transmission, dopaminergic" EXACT []
synonym: "down-regulation of synaptic transmission, dopaminergic" EXACT []
synonym: "downregulation of synaptic transmission, dopaminergic" EXACT []
synonym: "inhibition of synaptic transmission, dopaminergic" NARROW []
is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic
is_a: GO:0050805 ! negative regulation of synaptic transmission
relationship: negatively_regulates GO:0001963 ! synaptic transmission, dopaminergic

[Term]
id: GO:0032228
name: regulation of synaptic transmission, GABAergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah]
is_a: GO:0050804 ! regulation of synaptic transmission
relationship: regulates GO:0051932 ! synaptic transmission, GABAergic

[Term]
id: GO:0032229
name: negative regulation of synaptic transmission, GABAergic
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah]
synonym: "down regulation of synaptic transmission, GABAergic" EXACT []
synonym: "down-regulation of synaptic transmission, GABAergic" EXACT []
synonym: "downregulation of synaptic transmission, GABAergic" EXACT []
synonym: "inhibition of synaptic transmission, GABAergic" NARROW []
is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic
is_a: GO:0050805 ! negative regulation of synaptic transmission
relationship: negatively_regulates GO:0051932 ! synaptic transmission, GABAergic

[Term]
id: GO:0032230
name: positive regulation of synaptic transmission, GABAergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah]
synonym: "activation of synaptic transmission, GABAergic" NARROW []
synonym: "stimulation of synaptic transmission, GABAergic" NARROW []
synonym: "up regulation of synaptic transmission, GABAergic" EXACT []
synonym: "up-regulation of synaptic transmission, GABAergic" EXACT []
synonym: "upregulation of synaptic transmission, GABAergic" EXACT []
is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic
is_a: GO:0050806 ! positive regulation of synaptic transmission
relationship: positively_regulates GO:0051932 ! synaptic transmission, GABAergic

[Term]
id: GO:0032231
name: regulation of actin filament bundle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah]
synonym: "regulation of actin cable assembly" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of actin filament bundle formation" RELATED [GOC:dph]
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
relationship: regulates GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0032232
name: negative regulation of actin filament bundle assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah]
synonym: "down regulation of actin filament bundle formation" EXACT []
synonym: "down-regulation of actin filament bundle formation" EXACT []
synonym: "downregulation of actin filament bundle formation" EXACT []
synonym: "inhibition of actin filament bundle formation" NARROW []
is_a: GO:0032231 ! regulation of actin filament bundle assembly
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
relationship: negatively_regulates GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0032233
name: positive regulation of actin filament bundle assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah]
synonym: "activation of actin filament bundle formation" NARROW []
synonym: "stimulation of actin filament bundle formation" NARROW []
synonym: "up regulation of actin filament bundle formation" EXACT []
synonym: "up-regulation of actin filament bundle formation" EXACT []
synonym: "upregulation of actin filament bundle formation" EXACT []
is_a: GO:0032231 ! regulation of actin filament bundle assembly
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
relationship: positively_regulates GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0032234
name: regulation of calcium ion transport via store-operated calcium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901]
synonym: "regulation of calcium transport via store-operated calcium channel" EXACT []
synonym: "regulation of store-operated calcium channel activity" EXACT []
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:0051924 ! regulation of calcium ion transport

[Term]
id: GO:0032235
name: negative regulation of calcium ion transport via store-operated calcium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901]
synonym: "down regulation of calcium ion transport via store-operated calcium channel" EXACT []
synonym: "down-regulation of calcium ion transport via store-operated calcium channel" EXACT []
synonym: "downregulation of calcium ion transport via store-operated calcium channel" EXACT []
synonym: "inhibition of calcium ion transport via store-operated calcium channel" NARROW []
synonym: "negative regulation of calcium transport via store-operated calcium channel" EXACT []
synonym: "negative regulation of store-operated calcium channel activity" EXACT []
is_a: GO:0032234 ! regulation of calcium ion transport via store-operated calcium channel activity
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:0051926 ! negative regulation of calcium ion transport

[Term]
id: GO:0032236
name: positive regulation of calcium ion transport via store-operated calcium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901]
synonym: "activation of calcium ion transport via store-operated calcium channel" NARROW []
synonym: "positive regulation of calcium transport via store-operated calcium channel" EXACT []
synonym: "positive regulation of store-operated calcium channel activity" EXACT []
synonym: "stimulation of calcium ion transport via store-operated calcium channel" NARROW []
synonym: "up regulation of calcium ion transport via store-operated calcium channel" EXACT []
synonym: "up-regulation of calcium ion transport via store-operated calcium channel" EXACT []
synonym: "upregulation of calcium ion transport via store-operated calcium channel" EXACT []
is_a: GO:0032234 ! regulation of calcium ion transport via store-operated calcium channel activity
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:0051928 ! positive regulation of calcium ion transport

[Term]
id: GO:0032237
name: activation of store-operated calcium channel activity
namespace: biological_process
def: "A process that initiates the activity of an inactive store-operated calcium channel." [GOC:mah]
is_a: GO:0032236 ! positive regulation of calcium ion transport via store-operated calcium channel activity

[Term]
id: GO:0032238
name: adenosine transport
namespace: biological_process
def: "The directed movement of adenosine, adenine riboside, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
subset: gosubset_prok
is_a: GO:0015860 ! purine nucleoside transport

[Term]
id: GO:0032239
name: regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport

[Term]
id: GO:0032240
name: negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW []
is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport

[Term]
id: GO:0032241
name: positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW []
synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW []
synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT []
is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport

[Term]
id: GO:0032242
name: regulation of nucleoside transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a nucleoside into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
relationship: regulates GO:0015858 ! nucleoside transport

[Term]
id: GO:0032243
name: negative regulation of nucleoside transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of nucleoside transport" EXACT []
synonym: "down-regulation of nucleoside transport" EXACT []
synonym: "downregulation of nucleoside transport" EXACT []
synonym: "inhibition of nucleoside transport" NARROW []
is_a: GO:0032240 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
is_a: GO:0032242 ! regulation of nucleoside transport
relationship: negatively_regulates GO:0015858 ! nucleoside transport

[Term]
id: GO:0032244
name: positive regulation of nucleoside transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a nucleoside into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "activation of nucleoside transport" NARROW []
synonym: "stimulation of nucleoside transport" NARROW []
synonym: "up regulation of nucleoside transport" EXACT []
synonym: "up-regulation of nucleoside transport" EXACT []
synonym: "upregulation of nucleoside transport" EXACT []
is_a: GO:0032241 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
is_a: GO:0032242 ! regulation of nucleoside transport
relationship: positively_regulates GO:0015858 ! nucleoside transport

[Term]
id: GO:0032245
name: regulation of purine nucleoside transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a purine nucleoside into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032242 ! regulation of nucleoside transport
relationship: regulates GO:0015860 ! purine nucleoside transport

[Term]
id: GO:0032246
name: regulation of pyrimidine nucleoside transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a pyrimidine nucleoside into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032242 ! regulation of nucleoside transport
relationship: regulates GO:0015864 ! pyrimidine nucleoside transport

[Term]
id: GO:0032247
name: negative regulation of purine nucleoside transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of purine nucleoside transport" EXACT []
synonym: "down-regulation of purine nucleoside transport" EXACT []
synonym: "downregulation of purine nucleoside transport" EXACT []
synonym: "inhibition of purine nucleoside transport" NARROW []
is_a: GO:0032243 ! negative regulation of nucleoside transport
is_a: GO:0032245 ! regulation of purine nucleoside transport
relationship: negatively_regulates GO:0015860 ! purine nucleoside transport

[Term]
id: GO:0032248
name: positive regulation of purine nucleoside transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a purine nucleoside into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "activation of purine nucleoside transport" NARROW []
synonym: "stimulation of purine nucleoside transport" NARROW []
synonym: "up regulation of purine nucleoside transport" EXACT []
synonym: "up-regulation of purine nucleoside transport" EXACT []
synonym: "upregulation of purine nucleoside transport" EXACT []
is_a: GO:0032244 ! positive regulation of nucleoside transport
is_a: GO:0032245 ! regulation of purine nucleoside transport
relationship: positively_regulates GO:0015860 ! purine nucleoside transport

[Term]
id: GO:0032249
name: regulation of adenosine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of adenosine into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032245 ! regulation of purine nucleoside transport
relationship: regulates GO:0032238 ! adenosine transport

[Term]
id: GO:0032250
name: negative regulation of adenosine transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of adenosine into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of adenosine transport" EXACT []
synonym: "down-regulation of adenosine transport" EXACT []
synonym: "downregulation of adenosine transport" EXACT []
synonym: "inhibition of adenosine transport" NARROW []
is_a: GO:0032247 ! negative regulation of purine nucleoside transport
is_a: GO:0032249 ! regulation of adenosine transport
relationship: negatively_regulates GO:0032238 ! adenosine transport

[Term]
id: GO:0032251
name: positive regulation of adenosine transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of adenosine into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "activation of adenosine transport" NARROW []
synonym: "stimulation of adenosine transport" NARROW []
synonym: "up regulation of adenosine transport" EXACT []
synonym: "up-regulation of adenosine transport" EXACT []
synonym: "upregulation of adenosine transport" EXACT []
is_a: GO:0032248 ! positive regulation of purine nucleoside transport
is_a: GO:0032249 ! regulation of adenosine transport
relationship: positively_regulates GO:0032238 ! adenosine transport

[Term]
id: GO:0032252
name: secretory granule localization
namespace: biological_process
def: "Any process by which a secretory granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah]
synonym: "secretory granule clustering" RELATED []
is_a: GO:0051648 ! vesicle localization

[Term]
id: GO:0032253
name: dense core granule localization
namespace: biological_process
def: "Any process by which a dense core granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah]
synonym: "dense core granule clustering" RELATED []
synonym: "dense core vesicle localization" EXACT [GOC:kmv]
is_a: GO:0032252 ! secretory granule localization

[Term]
id: GO:0032254
name: establishment of secretory granule localization
namespace: biological_process
def: "The directed movement of a secretory granule to a specific location." [GOC:mah]
is_a: GO:0051650 ! establishment of vesicle localization
relationship: part_of GO:0032252 ! secretory granule localization

[Term]
id: GO:0032255
name: maintenance of secretory granule location
namespace: biological_process
def: "Any process by which a secretory granule is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of secretory granule localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051655 ! maintenance of vesicle location
relationship: part_of GO:0032252 ! secretory granule localization

[Term]
id: GO:0032256
name: establishment of dense core granule localization
namespace: biological_process
def: "The directed movement of a dense core granule to a specific location." [GOC:mah]
synonym: "establishment of dense core vesicle localization" EXACT [GOC:kmv]
is_a: GO:0032254 ! establishment of secretory granule localization
relationship: part_of GO:0032253 ! dense core granule localization

[Term]
id: GO:0032257
name: maintenance of dense core granule location
namespace: biological_process
def: "Any process by which a dense core granule is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of dense core granule localization" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of dense core vesicle location" EXACT [GOC:kmv]
is_a: GO:0032255 ! maintenance of secretory granule location
relationship: part_of GO:0032253 ! dense core granule localization

[Term]
id: GO:0032258
name: CVT pathway
namespace: biological_process
def: "A constitutive biosynthetic process that occurs under nutrient-rich conditions, in which two resident vacuolar hydrolases, aminopeptidase I and alpha-mannosidase, are sequestered into vesicles; these vesicles are transported to, and then fuse with, the vacuole. This pathway is mostly observed in yeast." [PMID:12865942, PMID:15659643]
synonym: "cytoplasm to vacuole targeting" EXACT []
synonym: "cytoplasm-to-vacuole targeting" EXACT []
is_a: GO:0006623 ! protein targeting to vacuole

[Term]
id: GO:0032259
name: methylation
namespace: biological_process
def: "The process by which a methyl group is covalently attached to a molecule." [GOC:mah]
xref: Reactome:156581 "Methylation"
xref: Reactome:448582 "Methylation"
xref: Reactome:469711 "Methylation"
xref: Reactome:487423 "Methylation"
xref: Reactome:507378 "Methylation"
xref: Reactome:517897 "Methylation"
xref: Reactome:526665 "Methylation"
xref: Reactome:531496 "Methylation"
xref: Reactome:536886 "Methylation"
xref: Reactome:542212 "Methylation"
xref: Reactome:547566 "Methylation"
xref: Reactome:552526 "Methylation"
xref: Reactome:557763 "Methylation"
xref: Reactome:568775 "Methylation"
xref: Reactome:581978 "Methylation"
xref: Reactome:586029 "Methylation"
xref: Reactome:592837 "Methylation"
xref: Reactome:595589 "Methylation"
xref: Reactome:597447 "Methylation"
xref: Reactome:598211 "Methylation"
xref: Reactome:599770 "Methylation"
xref: Reactome:600689 "Methylation"
xref: Reactome:602456 "Methylation"
xref: Wikipedia:Methylation
is_a: GO:0006730 ! one-carbon metabolic process

[Term]
id: GO:0032260
name: response to jasmonic acid stimulus during jasmonic acid and ethylene-dependent systemic resistance
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus received in the context of the jasmonic acid- and ethylene (ethene)-dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:mah]
is_a: GO:0009753 ! response to jasmonic acid stimulus
relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance

[Term]
id: GO:0032261
name: purine nucleotide salvage
namespace: biological_process
def: "Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis." [GOC:jp]
is_a: GO:0006164 ! purine nucleotide biosynthetic process
is_a: GO:0043101 ! purine salvage
is_a: GO:0043173 ! nucleotide salvage

[Term]
id: GO:0032262
name: pyrimidine nucleotide salvage
namespace: biological_process
def: "Any process which produces a pyrimidine nucleotide from derivatives of it, without de novo synthesis." [GOC:mah]
is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process
is_a: GO:0008655 ! pyrimidine salvage
is_a: GO:0043173 ! nucleotide salvage

[Term]
id: GO:0032263
name: GMP salvage
namespace: biological_process
def: "Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah]
is_a: GO:0006177 ! GMP biosynthetic process
is_a: GO:0032261 ! purine nucleotide salvage

[Term]
id: GO:0032264
name: IMP salvage
namespace: biological_process
def: "Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah]
is_a: GO:0006188 ! IMP biosynthetic process
is_a: GO:0032261 ! purine nucleotide salvage

[Term]
id: GO:0032265
name: XMP salvage
namespace: biological_process
def: "Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah]
is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process
is_a: GO:0032261 ! purine nucleotide salvage

[Term]
id: GO:0032266
name: phosphatidylinositol 3-phosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol 3-phosphate, a phosphorylated derivative of phosphatidylinositol." [PMID:11557775]
synonym: "PtdIns-3-P binding" EXACT []
is_a: GO:0005545 ! phosphatidylinositol binding

[Term]
id: GO:0032267
name: tRNA(Ile)-lysidine synthase activity
namespace: molecular_function
def: "Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine." [PMID:14527414]
synonym: "tRNA(Ile)-2-lysyl-cytidine synthase activity" EXACT []
synonym: "tRNA(Ile)-lysidine synthetase activity" EXACT []
xref: EC:6.3.4.-
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0032268
name: regulation of cellular protein metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of cellular protein metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: regulates GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0032269
name: negative regulation of cellular protein metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah]
synonym: "down regulation of cellular protein metabolic process" EXACT []
synonym: "down-regulation of cellular protein metabolic process" EXACT []
synonym: "downregulation of cellular protein metabolic process" EXACT []
synonym: "inhibition of cellular protein metabolic process" NARROW []
synonym: "negative regulation of cellular protein metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
relationship: negatively_regulates GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0032270
name: positive regulation of cellular protein metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah]
synonym: "activation of cellular protein metabolic process" NARROW []
synonym: "positive regulation of cellular protein metabolism" EXACT []
synonym: "stimulation of cellular protein metabolic process" NARROW []
synonym: "up regulation of cellular protein metabolic process" EXACT []
synonym: "up-regulation of cellular protein metabolic process" EXACT []
synonym: "upregulation of cellular protein metabolic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
relationship: positively_regulates GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0032271
name: regulation of protein polymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]
synonym: "regulation of protein polymerisation" EXACT []
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0051258 ! protein polymerization

[Term]
id: GO:0032272
name: negative regulation of protein polymerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]
synonym: "down regulation of protein polymerization" EXACT []
synonym: "down-regulation of protein polymerization" EXACT []
synonym: "downregulation of protein polymerization" EXACT []
synonym: "inhibition of protein polymerization" NARROW []
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0032271 ! regulation of protein polymerization
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0051258 ! protein polymerization

[Term]
id: GO:0032273
name: positive regulation of protein polymerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah]
synonym: "activation of protein polymerization" NARROW []
synonym: "stimulation of protein polymerization" NARROW []
synonym: "up regulation of protein polymerization" EXACT []
synonym: "up-regulation of protein polymerization" EXACT []
synonym: "upregulation of protein polymerization" EXACT []
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0032271 ! regulation of protein polymerization
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0051258 ! protein polymerization

[Term]
id: GO:0032274
name: gonadotropin secretion
namespace: biological_process
def: "The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone." [GOC:mah, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "gonadotrophin secretion" EXACT []
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0032275
name: luteinizing hormone secretion
namespace: biological_process
def: "The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0032276
name: regulation of gonadotropin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah]
synonym: "regulation of gonadotrophin secretion" EXACT []
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0032277
name: negative regulation of gonadotropin secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah]
synonym: "down regulation of gonadotropin secretion" EXACT []
synonym: "down-regulation of gonadotropin secretion" EXACT []
synonym: "downregulation of gonadotropin secretion" EXACT []
synonym: "inhibition of gonadotropin secretion" NARROW []
synonym: "negative regulation of gonadotrophin secretion" EXACT []
is_a: GO:0032276 ! regulation of gonadotropin secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
relationship: negatively_regulates GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0032278
name: positive regulation of gonadotropin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah]
synonym: "activation of gonadotropin secretion" NARROW []
synonym: "positive regulation of gonadotrophin secretion" EXACT []
synonym: "stimulation of gonadotropin secretion" NARROW []
synonym: "up regulation of gonadotropin secretion" EXACT []
synonym: "up-regulation of gonadotropin secretion" EXACT []
synonym: "upregulation of gonadotropin secretion" EXACT []
is_a: GO:0032276 ! regulation of gonadotropin secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
relationship: positively_regulates GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0032279
name: asymmetric synapse
namespace: cellular_component
def: "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density." [GOC:dgh, GOC:ef]
is_a: GO:0045202 ! synapse

[Term]
id: GO:0032280
name: symmetric synapse
namespace: cellular_component
def: "A type of synapse occurring primarily on dendrite shafts and neuronal cell bodies. Symmetric synapses involve axons containing clusters of predominantly flattened or elongated vesicles and do not contain a prominent postsynaptic density." [GOC:dgh, GOC:ef]
is_a: GO:0045202 ! synapse

[Term]
id: GO:0032281
name: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
namespace: cellular_component
def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus." [GOC:ef]
synonym: "AMPA receptor " RELATED []
synonym: "AMPA-selective glutamate receptor complex" EXACT []
is_a: GO:0008328 ! ionotropic glutamate receptor complex

[Term]
id: GO:0032282
name: plastid acetyl-CoA carboxylase complex
namespace: cellular_component
def: "An acetyl-CoA carboxylase complex located in the stroma of a plastid." [GOC:mah]
synonym: "plastid ACCase complex" EXACT []
is_a: GO:0009317 ! acetyl-CoA carboxylase complex
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009532 ! plastid stroma

[Term]
id: GO:0032283
name: plastid acetate CoA-transferase complex
namespace: cellular_component
def: "An acetate CoA-transferase complex located in the stroma of a plastid." [GOC:mah]
is_a: GO:0009329 ! acetate CoA-transferase complex
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex

[Term]
id: GO:0032284
name: plastid biotin carboxylase complex
namespace: cellular_component
def: "A biotin carboxylase complex located in the stroma of a plastid." [GOC:mah]
is_a: GO:0009343 ! biotin carboxylase complex
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex

[Term]
id: GO:0032285
name: ensheathment of non-myelinated axons
namespace: biological_process
def: "The process by which a non-myelinating glial cell membrane closes around an axon." [GOC:dgh]
is_a: GO:0008366 ! axon ensheathment

[Term]
id: GO:0032286
name: myelin maintenance in the central nervous system
namespace: biological_process
def: "The process by which the structure and material content of mature central nervous system myelin is kept in a functional state." [GOC:dgh]
is_a: GO:0043217 ! myelin maintenance
relationship: part_of GO:0022010 ! myelination in the central nervous system

[Term]
id: GO:0032287
name: myelin maintenance in the peripheral nervous system
namespace: biological_process
def: "The process by which the structure and material content of mature peripheral nervous system myelin is kept in a functional state." [GOC:dgh]
is_a: GO:0043217 ! myelin maintenance
relationship: part_of GO:0022011 ! myelination in the peripheral nervous system

[Term]
id: GO:0032288
name: myelin assembly
namespace: biological_process
def: "The process by which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system." [GOC:dgh, GOC:dph, GOC:tb]
synonym: "myelin formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0010927 ! cellular component assembly involved in morphogenesis
relationship: part_of GO:0042552 ! myelination

[Term]
id: GO:0032289
name: myelin formation in the central nervous system
namespace: biological_process
def: "The process by which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system." [GOC:dgh]
is_a: GO:0032288 ! myelin assembly
relationship: part_of GO:0022010 ! myelination in the central nervous system

[Term]
id: GO:0032290
name: myelin formation in the peripheral nervous system
namespace: biological_process
def: "The process by which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the peripheral nervous system." [GOC:dgh]
is_a: GO:0032288 ! myelin assembly
relationship: part_of GO:0022011 ! myelination in the peripheral nervous system

[Term]
id: GO:0032291
name: ensheathment of axons in the central nervous system
namespace: biological_process
def: "The process by which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh]
is_a: GO:0008366 ! axon ensheathment

[Term]
id: GO:0032292
name: ensheathment of axons in the peripheral nervous system
namespace: biological_process
def: "The process by which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh]
is_a: GO:0008366 ! axon ensheathment

[Term]
id: GO:0032293
name: ensheathment of non-myelinated axons in the central nervous system
namespace: biological_process
def: "The process by which a non-myelinating glial cell membrane encircles an axon in the central nervous system." [GOC:dgh]
is_a: GO:0032285 ! ensheathment of non-myelinated axons
is_a: GO:0032291 ! ensheathment of axons in the central nervous system

[Term]
id: GO:0032294
name: ensheathment of non-myelinated axons in the peripheral nervous system
namespace: biological_process
def: "The process by which a non-myelinating Schwann cell membrane encircles an axon in the peripheral nervous system. A single non-myelinating Schwann cell will typically associate with multiple axons." [GOC:dgh]
is_a: GO:0032285 ! ensheathment of non-myelinated axons
is_a: GO:0032292 ! ensheathment of axons in the peripheral nervous system

[Term]
id: GO:0032295
name: ensheathment of neuronal cell bodies
namespace: biological_process
def: "The process by which satellite glial cells isolate neuronal cell bodies." [GOC:dgh]
is_a: GO:0007272 ! ensheathment of neurons

[Term]
id: GO:0032296
name: double-stranded RNA-specific ribonuclease activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules." [GOC:mah]
synonym: "double-stranded RNA-specific RNase activity" EXACT []
synonym: "dsRNA-specific ribonuclease activity" EXACT []
synonym: "dsRNA-specific RNase activity" EXACT []
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0032297
name: negative regulation of DNA replication initiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of initiation of DNA replication." [GOC:mah]
synonym: "down regulation of DNA replication initiation" EXACT []
synonym: "down-regulation of DNA replication initiation" EXACT []
synonym: "downregulation of DNA replication initiation" EXACT []
synonym: "inhibition of DNA replication initiation" NARROW []
is_a: GO:0008156 ! negative regulation of DNA replication
is_a: GO:0030174 ! regulation of DNA replication initiation
relationship: negatively_regulates GO:0006270 ! DNA replication initiation

[Term]
id: GO:0032298
name: positive regulation of DNA replication initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of initiation of DNA replication." [GOC:mah]
synonym: "activation of DNA replication initiation" NARROW []
synonym: "stimulation of DNA replication initiation" NARROW []
synonym: "up regulation of DNA replication initiation" EXACT []
synonym: "up-regulation of DNA replication initiation" EXACT []
synonym: "upregulation of DNA replication initiation" EXACT []
is_a: GO:0030174 ! regulation of DNA replication initiation
is_a: GO:0045740 ! positive regulation of DNA replication
relationship: positively_regulates GO:0006270 ! DNA replication initiation

[Term]
id: GO:0032299
name: ribonuclease H2 complex
namespace: cellular_component
def: "A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p." [GOC:mah, PMID:14734815]
synonym: "RNase H2 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0032300
name: mismatch repair complex
namespace: cellular_component
def: "Any complex formed of proteins that act in mismatch repair." [GOC:mah]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0032301
name: MutSalpha complex
namespace: cellular_component
def: "A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6." [PMID:11005803]
synonym: "MMR complex" BROAD []
synonym: "MSH2/MSH6 complex" EXACT []
is_a: GO:0032300 ! mismatch repair complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032302
name: MutSbeta complex
namespace: cellular_component
def: "A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3." [PMID:11005803]
synonym: "MMR complex" BROAD []
synonym: "MSH2/MSH3 complex" EXACT []
is_a: GO:0032300 ! mismatch repair complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032303
name: regulation of icosanoid secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell or group of cells." [GOC:mah]
synonym: "regulation of eicosanoid secretion" EXACT []
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051046 ! regulation of secretion
relationship: regulates GO:0032309 ! icosanoid secretion

[Term]
id: GO:0032304
name: negative regulation of icosanoid secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell or group of cells." [GOC:mah]
synonym: "down regulation of icosanoid secretion" EXACT []
synonym: "down-regulation of icosanoid secretion" EXACT []
synonym: "downregulation of icosanoid secretion" EXACT []
synonym: "inhibition of icosanoid secretion" NARROW []
synonym: "negative regulation of eicosanoid secretion" EXACT []
is_a: GO:0032303 ! regulation of icosanoid secretion
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0051048 ! negative regulation of secretion
relationship: negatively_regulates GO:0032309 ! icosanoid secretion

[Term]
id: GO:0032305
name: positive regulation of icosanoid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell or group of cells." [GOC:mah]
synonym: "activation of icosanoid secretion" NARROW []
synonym: "positive regulation of eicosanoid secretion" EXACT []
synonym: "stimulation of icosanoid secretion" NARROW []
synonym: "up regulation of icosanoid secretion" EXACT []
synonym: "up-regulation of icosanoid secretion" EXACT []
synonym: "upregulation of icosanoid secretion" EXACT []
is_a: GO:0032303 ! regulation of icosanoid secretion
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0051047 ! positive regulation of secretion
relationship: positively_regulates GO:0032309 ! icosanoid secretion

[Term]
id: GO:0032306
name: regulation of prostaglandin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell or group of cells." [GOC:mah]
synonym: "regulation of prostacyclin secretion" NARROW []
is_a: GO:0032303 ! regulation of icosanoid secretion
relationship: regulates GO:0032310 ! prostaglandin secretion

[Term]
id: GO:0032307
name: negative regulation of prostaglandin secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a prostaglandin from a cell or group of cells." [GOC:mah]
synonym: "down regulation of prostaglandin secretion" EXACT []
synonym: "down-regulation of prostaglandin secretion" EXACT []
synonym: "downregulation of prostaglandin secretion" EXACT []
synonym: "inhibition of prostaglandin secretion" NARROW []
synonym: "negative regulation of prostacyclin secretion" NARROW []
is_a: GO:0032304 ! negative regulation of icosanoid secretion
is_a: GO:0032306 ! regulation of prostaglandin secretion
relationship: negatively_regulates GO:0032310 ! prostaglandin secretion

[Term]
id: GO:0032308
name: positive regulation of prostaglandin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell or group of cells." [GOC:mah]
synonym: "activation of prostaglandin secretion" NARROW []
synonym: "positive regulation of prostacyclin secretion" NARROW []
synonym: "stimulation of prostaglandin secretion" NARROW []
synonym: "up regulation of prostaglandin secretion" EXACT []
synonym: "up-regulation of prostaglandin secretion" EXACT []
synonym: "upregulation of prostaglandin secretion" EXACT []
is_a: GO:0032305 ! positive regulation of icosanoid secretion
is_a: GO:0032306 ! regulation of prostaglandin secretion
relationship: positively_regulates GO:0032310 ! prostaglandin secretion

[Term]
id: GO:0032309
name: icosanoid secretion
namespace: biological_process
def: "The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids." [GOC:mah]
synonym: "eicosanoid secretion" EXACT []
is_a: GO:0015908 ! fatty acid transport
is_a: GO:0046903 ! secretion

[Term]
id: GO:0032310
name: prostaglandin secretion
namespace: biological_process
def: "The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring." [GOC:mah]
synonym: "prostacyclin secretion" NARROW []
is_a: GO:0015732 ! prostaglandin transport
is_a: GO:0032309 ! icosanoid secretion

[Term]
id: GO:0032311
name: angiogenin-PRI complex
namespace: cellular_component
def: "A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis." [PMID:2706246, PMID:3470787]
synonym: "angiogenin-placental ribonuclease inhibitor complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0032312
name: regulation of ARF GTPase activity
namespace: biological_process
def: "Any process that modulates the activity of the GTPase ARF." [GOC:mah]
is_a: GO:0032318 ! regulation of Ras GTPase activity
relationship: part_of GO:0032012 ! regulation of ARF protein signal transduction

[Term]
id: GO:0032313
name: regulation of Rab GTPase activity
namespace: biological_process
def: "Any process that modulates the activity of a GTPase of the Rab family." [GOC:mah]
is_a: GO:0032318 ! regulation of Ras GTPase activity
relationship: part_of GO:0032483 ! regulation of Rab protein signal transduction

[Term]
id: GO:0032314
name: regulation of Rac GTPase activity
namespace: biological_process
def: "Any process that modulates the activity of a GTPase of the Rac family." [GOC:mah]
is_a: GO:0032319 ! regulation of Rho GTPase activity
relationship: part_of GO:0035020 ! regulation of Rac protein signal transduction

[Term]
id: GO:0032315
name: regulation of Ral GTPase activity
namespace: biological_process
def: "Any process that modulates the activity of a GTPase of the Ral family." [GOC:mah]
is_a: GO:0032318 ! regulation of Ras GTPase activity
relationship: part_of GO:0032485 ! regulation of Ral protein signal transduction

[Term]
id: GO:0032316
name: regulation of Ran GTPase activity
namespace: biological_process
def: "Any process that modulates the activity of a GTPase of the Ran family." [GOC:mah]
is_a: GO:0032318 ! regulation of Ras GTPase activity
relationship: part_of GO:0032015 ! regulation of Ran protein signal transduction

[Term]
id: GO:0032317
name: regulation of Rap GTPase activity
namespace: biological_process
def: "Any process that modulates the activity of a GTPase of the Rap family." [GOC:mah]
is_a: GO:0032318 ! regulation of Ras GTPase activity
relationship: part_of GO:0032487 ! regulation of Rap protein signal transduction

[Term]
id: GO:0032318
name: regulation of Ras GTPase activity
namespace: biological_process
def: "Any process that modulates the activity of a GTPase of the Ras superfamily." [GOC:mah]
is_a: GO:0043087 ! regulation of GTPase activity
relationship: part_of GO:0046578 ! regulation of Ras protein signal transduction

[Term]
id: GO:0032319
name: regulation of Rho GTPase activity
namespace: biological_process
def: "Any process that modulates the activity of a GTPase of the Rho family." [GOC:mah]
is_a: GO:0032318 ! regulation of Ras GTPase activity
relationship: part_of GO:0035023 ! regulation of Rho protein signal transduction

[Term]
id: GO:0032320
name: positive regulation of Ras GTPase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a GTPase of the Ras superfamily." [GOC:mah]
synonym: "stimulation of Ras GTPase activity" NARROW []
synonym: "up regulation of Ras GTPase activity" EXACT []
synonym: "up-regulation of Ras GTPase activity" EXACT []
synonym: "upregulation of Ras GTPase activity" EXACT []
is_a: GO:0032318 ! regulation of Ras GTPase activity
is_a: GO:0043547 ! positive regulation of GTPase activity

[Term]
id: GO:0032321
name: positive regulation of Rho GTPase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a GTPase of the Rho family." [GOC:mah]
synonym: "stimulation of Rho GTPase activity" NARROW []
synonym: "up regulation of Rho GTPase activity" EXACT []
synonym: "up-regulation of Rho GTPase activity" EXACT []
synonym: "upregulation of Rho GTPase activity" EXACT []
is_a: GO:0032319 ! regulation of Rho GTPase activity
is_a: GO:0032320 ! positive regulation of Ras GTPase activity

[Term]
id: GO:0032322
name: ubiquinone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah]
synonym: "ubiquinone breakdown" EXACT []
synonym: "ubiquinone catabolism" EXACT []
synonym: "ubiquinone degradation" EXACT []
is_a: GO:0006743 ! ubiquinone metabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0042378 ! quinone cofactor catabolic process

[Term]
id: GO:0032323
name: lipoic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipoic acid, 1,2-dithiolane-3-pentanoic acid, a coenzyme involved in oxidative decarboxylation of keto acids." [GOC:mah]
synonym: "lipoic acid breakdown" EXACT []
synonym: "lipoic acid catabolism" EXACT []
synonym: "lipoic acid degradation" EXACT []
is_a: GO:0000273 ! lipoic acid metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0032324
name: molybdopterin cofactor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah]
synonym: "molybdopterin cofactor anabolism" EXACT []
synonym: "molybdopterin cofactor biosynthesis" RELATED []
synonym: "molybdopterin cofactor formation" RELATED []
synonym: "molybdopterin cofactor synthesis" EXACT []
is_a: GO:0042559 ! pteridine and derivative biosynthetic process
is_a: GO:0043545 ! molybdopterin cofactor metabolic process
is_a: GO:0051188 ! cofactor biosynthetic process

[Term]
id: GO:0032325
name: molybdopterin cofactor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah]
is_a: GO:0043545 ! molybdopterin cofactor metabolic process
is_a: GO:0051187 ! cofactor catabolic process

[Term]
id: GO:0032326
name: Mo-molybdopterin cofactor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [GOC:mah]
subset: gosubset_prok
synonym: "Mo-molybdopterin cofactor breakdown" EXACT []
synonym: "Mo-molybdopterin cofactor catabolism" EXACT []
synonym: "Mo-molybdopterin cofactor degradation" EXACT []
synonym: "Moco catabolic process" BROAD []
synonym: "Moco catabolism" BROAD []
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process
is_a: GO:0032325 ! molybdopterin cofactor catabolic process
is_a: GO:0042559 ! pteridine and derivative biosynthetic process

[Term]
id: GO:0032327
name: W-molybdopterin cofactor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [GOC:mah]
subset: gosubset_prok
synonym: "Moco catabolic process" BROAD []
synonym: "Moco catabolism" BROAD []
synonym: "W-molybdopterin cofactor breakdown" EXACT []
synonym: "W-molybdopterin cofactor catabolism" EXACT []
synonym: "W-molybdopterin cofactor degradation" EXACT []
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0032325 ! molybdopterin cofactor catabolic process
is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process
is_a: GO:0042559 ! pteridine and derivative biosynthetic process

[Term]
id: GO:0032328
name: alanine transport
namespace: biological_process
def: "The directed movement of alanine, 2-aminopropanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0032329
name: serine transport
namespace: biological_process
def: "The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0032330
name: regulation of chondrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chondrocyte differentiation." [GOC:mah]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0061035 ! regulation of cartilage development
relationship: regulates GO:0002062 ! chondrocyte differentiation

[Term]
id: GO:0032331
name: negative regulation of chondrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chondrocyte differentiation." [GOC:mah]
synonym: "down regulation of chondrocyte differentiation" EXACT []
synonym: "down-regulation of chondrocyte differentiation" EXACT []
synonym: "downregulation of chondrocyte differentiation" EXACT []
synonym: "inhibition of chondrocyte differentiation" NARROW []
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: negatively_regulates GO:0002062 ! chondrocyte differentiation

[Term]
id: GO:0032332
name: positive regulation of chondrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation." [GOC:mah]
synonym: "activation of chondrocyte differentiation" NARROW []
synonym: "stimulation of chondrocyte differentiation" NARROW []
synonym: "up regulation of chondrocyte differentiation" EXACT []
synonym: "up-regulation of chondrocyte differentiation" EXACT []
synonym: "upregulation of chondrocyte differentiation" EXACT []
is_a: GO:0032330 ! regulation of chondrocyte differentiation
is_a: GO:0045597 ! positive regulation of cell differentiation
relationship: positively_regulates GO:0002062 ! chondrocyte differentiation

[Term]
id: GO:0032333
name: activin secretion
namespace: biological_process
def: "The regulated release of activin, a nonsteroidal regulator composed of two covalently linked beta subunits, which is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [GOC:mah]
is_a: GO:0046879 ! hormone secretion

[Term]
id: GO:0032334
name: inhibin secretion
namespace: biological_process
def: "The regulated release of an inhibin, either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [GOC:mah]
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0032335
name: regulation of activin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of activin from a cell or group of cells." [GOC:mah]
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0032333 ! activin secretion

[Term]
id: GO:0032336
name: negative regulation of activin secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of activin from a cell or group of cells." [GOC:mah]
synonym: "down regulation of activin secretion" EXACT []
synonym: "down-regulation of activin secretion" EXACT []
synonym: "downregulation of activin secretion" EXACT []
synonym: "inhibition of activin secretion" NARROW []
is_a: GO:0032335 ! regulation of activin secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
relationship: negatively_regulates GO:0032333 ! activin secretion

[Term]
id: GO:0032337
name: positive regulation of activin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of activin from a cell or group of cells." [GOC:mah]
synonym: "activation of activin secretion" NARROW []
synonym: "stimulation of activin secretion" NARROW []
synonym: "up regulation of activin secretion" EXACT []
synonym: "up-regulation of activin secretion" EXACT []
synonym: "upregulation of activin secretion" EXACT []
is_a: GO:0032335 ! regulation of activin secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
relationship: positively_regulates GO:0032333 ! activin secretion

[Term]
id: GO:0032338
name: regulation of inhibin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of inhibin from a cell or group of cells." [GOC:mah]
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0032334 ! inhibin secretion

[Term]
id: GO:0032339
name: negative regulation of inhibin secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of inhibin from a cell or group of cells." [GOC:mah]
synonym: "down regulation of inhibin secretion" EXACT []
synonym: "down-regulation of inhibin secretion" EXACT []
synonym: "downregulation of inhibin secretion" EXACT []
synonym: "inhibition of inhibin secretion" NARROW []
is_a: GO:0032338 ! regulation of inhibin secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
relationship: negatively_regulates GO:0032334 ! inhibin secretion

[Term]
id: GO:0032340
name: positive regulation of inhibin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of inhibin from a cell or group of cells." [GOC:mah]
synonym: "activation of inhibin secretion" NARROW []
synonym: "stimulation of inhibin secretion" NARROW []
synonym: "up regulation of inhibin secretion" EXACT []
synonym: "up-regulation of inhibin secretion" EXACT []
synonym: "upregulation of inhibin secretion" EXACT []
is_a: GO:0032338 ! regulation of inhibin secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
relationship: positively_regulates GO:0032334 ! inhibin secretion

[Term]
id: GO:0032341
name: aldosterone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843]
synonym: "aldosterone metabolism" EXACT []
is_a: GO:0008212 ! mineralocorticoid metabolic process

[Term]
id: GO:0032342
name: aldosterone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843]
is_a: GO:0006705 ! mineralocorticoid biosynthetic process
is_a: GO:0032341 ! aldosterone metabolic process

[Term]
id: GO:0032343
name: aldosterone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843]
is_a: GO:0006712 ! mineralocorticoid catabolic process
is_a: GO:0032341 ! aldosterone metabolic process

[Term]
id: GO:0032344
name: regulation of aldosterone metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah]
synonym: "regulation of aldosterone metabolism" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
relationship: regulates GO:0032341 ! aldosterone metabolic process

[Term]
id: GO:0032345
name: negative regulation of aldosterone metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah]
synonym: "down regulation of aldosterone metabolic process" EXACT []
synonym: "down-regulation of aldosterone metabolic process" EXACT []
synonym: "downregulation of aldosterone metabolic process" EXACT []
synonym: "inhibition of aldosterone metabolic process" NARROW []
synonym: "negative regulation of aldosterone metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0032344 ! regulation of aldosterone metabolic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0045939 ! negative regulation of steroid metabolic process
relationship: negatively_regulates GO:0032341 ! aldosterone metabolic process

[Term]
id: GO:0032346
name: positive regulation of aldosterone metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah]
synonym: "activation of aldosterone metabolic process" NARROW []
synonym: "positive regulation of aldosterone metabolism" EXACT []
synonym: "stimulation of aldosterone metabolic process" NARROW []
synonym: "up regulation of aldosterone metabolic process" EXACT []
synonym: "up-regulation of aldosterone metabolic process" EXACT []
synonym: "upregulation of aldosterone metabolic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0032344 ! regulation of aldosterone metabolic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0045940 ! positive regulation of steroid metabolic process
relationship: positively_regulates GO:0032341 ! aldosterone metabolic process

[Term]
id: GO:0032347
name: regulation of aldosterone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah]
is_a: GO:0032344 ! regulation of aldosterone metabolic process
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process
relationship: regulates GO:0032342 ! aldosterone biosynthetic process

[Term]
id: GO:0032348
name: negative regulation of aldosterone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah]
synonym: "down regulation of aldosterone biosynthetic process" EXACT []
synonym: "down-regulation of aldosterone biosynthetic process" EXACT []
synonym: "downregulation of aldosterone biosynthetic process" EXACT []
synonym: "inhibition of aldosterone biosynthetic process" NARROW []
is_a: GO:0032345 ! negative regulation of aldosterone metabolic process
is_a: GO:0032347 ! regulation of aldosterone biosynthetic process
is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process
relationship: negatively_regulates GO:0032342 ! aldosterone biosynthetic process

[Term]
id: GO:0032349
name: positive regulation of aldosterone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah]
synonym: "activation of aldosterone biosynthetic process" NARROW []
synonym: "stimulation of aldosterone biosynthetic process" NARROW []
synonym: "up regulation of aldosterone biosynthetic process" EXACT []
synonym: "up-regulation of aldosterone biosynthetic process" EXACT []
synonym: "upregulation of aldosterone biosynthetic process" EXACT []
is_a: GO:0032346 ! positive regulation of aldosterone metabolic process
is_a: GO:0032347 ! regulation of aldosterone biosynthetic process
is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process
relationship: positively_regulates GO:0032342 ! aldosterone biosynthetic process

[Term]
id: GO:0032350
name: regulation of hormone metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah]
synonym: "regulation of hormone metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0042445 ! hormone metabolic process

[Term]
id: GO:0032351
name: negative regulation of hormone metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah]
synonym: "down regulation of hormone metabolic process" EXACT []
synonym: "down-regulation of hormone metabolic process" EXACT []
synonym: "downregulation of hormone metabolic process" EXACT []
synonym: "inhibition of hormone metabolic process" NARROW []
synonym: "negative regulation of hormone metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
relationship: negatively_regulates GO:0042445 ! hormone metabolic process

[Term]
id: GO:0032352
name: positive regulation of hormone metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah]
synonym: "activation of hormone metabolic process" NARROW []
synonym: "positive regulation of hormone metabolism" EXACT []
synonym: "stimulation of hormone metabolic process" NARROW []
synonym: "up regulation of hormone metabolic process" EXACT []
synonym: "up-regulation of hormone metabolic process" EXACT []
synonym: "upregulation of hormone metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0032350 ! regulation of hormone metabolic process
relationship: positively_regulates GO:0042445 ! hormone metabolic process

[Term]
id: GO:0032353
name: negative regulation of hormone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai]
synonym: "down regulation of hormone biosynthetic process" EXACT []
synonym: "down-regulation of hormone biosynthetic process" EXACT []
synonym: "downregulation of hormone biosynthetic process" EXACT []
synonym: "inhibition of hormone biosynthetic process" NARROW []
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0046885 ! regulation of hormone biosynthetic process
relationship: negatively_regulates GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0032354
name: response to follicle-stimulating hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus." [GOC:mah]
is_a: GO:0034698 ! response to gonadotropin stimulus

[Term]
id: GO:0032355
name: response to estradiol stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah, ISBN:0911910123]
synonym: "response to E2 stimulus" EXACT []
is_a: GO:0043627 ! response to estrogen stimulus

[Term]
id: GO:0032356
name: oxidized DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with oxidized residues in DNA." [GOC:vk]
synonym: "oxidised DNA binding" EXACT []
is_a: GO:0003684 ! damaged DNA binding

[Term]
id: GO:0032357
name: oxidized purine DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with oxidized purine residues in DNA." [GOC:vk]
synonym: "oxidised purine DNA binding" EXACT []
is_a: GO:0032356 ! oxidized DNA binding

[Term]
id: GO:0032358
name: oxidized pyrimidine DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with oxidized pyrimidine residues in DNA." [GOC:vk]
synonym: "oxidised pyrimidine DNA binding" EXACT []
is_a: GO:0032356 ! oxidized DNA binding

[Term]
id: GO:0032359
name: provirus excision
namespace: biological_process
def: "The molecular events that lead to the excision of a viral genome from the host genome." [GOC:mlg]
synonym: "prophage excision" EXACT []
is_a: GO:0022415 ! viral reproductive process

[Term]
id: GO:0032360
name: provirus maintenance
namespace: biological_process
def: "The molecular events that maintain a viral genome integrated into a host genome." [GOC:mlg]
synonym: "prophage maintenance" EXACT []
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0030069 ! lysogeny

[Term]
id: GO:0032361
name: pyridoxal phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:mah]
is_a: GO:0042820 ! vitamin B6 catabolic process
is_a: GO:0042822 ! pyridoxal phosphate metabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:0051187 ! cofactor catabolic process

[Term]
id: GO:0032362
name: FAD catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah]
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0042728 ! riboflavin and derivative catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046434 ! organophosphate catabolic process
is_a: GO:0046443 ! FAD metabolic process

[Term]
id: GO:0032363
name: FMN catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:mah]
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process
is_a: GO:0042728 ! riboflavin and derivative catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046444 ! FMN metabolic process

[Term]
id: GO:0032364
name: oxygen homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal equilibrium of oxygen within an organism or cell." [GOC:rph]
is_a: GO:0033483 ! gas homeostasis

[Term]
id: GO:0032365
name: intracellular lipid transport
namespace: biological_process
def: "The directed movement of lipids within cells." [GOC:mah]
is_a: GO:0006869 ! lipid transport
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0032366
name: intracellular sterol transport
namespace: biological_process
def: "The directed movement of sterols within cells." [GOC:mah]
is_a: GO:0015918 ! sterol transport
is_a: GO:0032365 ! intracellular lipid transport

[Term]
id: GO:0032367
name: intracellular cholesterol transport
namespace: biological_process
def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells." [GOC:mah]
is_a: GO:0030301 ! cholesterol transport
is_a: GO:0032366 ! intracellular sterol transport

[Term]
id: GO:0032368
name: regulation of lipid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0006869 ! lipid transport

[Term]
id: GO:0032369
name: negative regulation of lipid transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of lipid transport" EXACT []
synonym: "down-regulation of lipid transport" EXACT []
synonym: "downregulation of lipid transport" EXACT []
synonym: "inhibition of lipid transport" NARROW []
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0006869 ! lipid transport

[Term]
id: GO:0032370
name: positive regulation of lipid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "activation of lipid transport" NARROW []
synonym: "stimulation of lipid transport" NARROW []
synonym: "up regulation of lipid transport" EXACT []
synonym: "up-regulation of lipid transport" EXACT []
synonym: "upregulation of lipid transport" EXACT []
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0006869 ! lipid transport

[Term]
id: GO:0032371
name: regulation of sterol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032368 ! regulation of lipid transport
relationship: regulates GO:0015918 ! sterol transport

[Term]
id: GO:0032372
name: negative regulation of sterol transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of sterols into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of sterol transport" EXACT []
synonym: "down-regulation of sterol transport" EXACT []
synonym: "downregulation of sterol transport" EXACT []
synonym: "inhibition of sterol transport" NARROW []
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0032371 ! regulation of sterol transport
relationship: negatively_regulates GO:0015918 ! sterol transport

[Term]
id: GO:0032373
name: positive regulation of sterol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "activation of sterol transport" NARROW []
synonym: "stimulation of sterol transport" NARROW []
synonym: "up regulation of sterol transport" EXACT []
synonym: "up-regulation of sterol transport" EXACT []
synonym: "upregulation of sterol transport" EXACT []
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0032371 ! regulation of sterol transport
relationship: positively_regulates GO:0015918 ! sterol transport

[Term]
id: GO:0032374
name: regulation of cholesterol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032371 ! regulation of sterol transport
relationship: regulates GO:0030301 ! cholesterol transport

[Term]
id: GO:0032375
name: negative regulation of cholesterol transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of cholesterol transport" EXACT []
synonym: "down-regulation of cholesterol transport" EXACT []
synonym: "downregulation of cholesterol transport" EXACT []
synonym: "inhibition of cholesterol transport" NARROW []
is_a: GO:0032372 ! negative regulation of sterol transport
is_a: GO:0032374 ! regulation of cholesterol transport
relationship: negatively_regulates GO:0030301 ! cholesterol transport

[Term]
id: GO:0032376
name: positive regulation of cholesterol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "activation of cholesterol transport" NARROW []
synonym: "stimulation of cholesterol transport" NARROW []
synonym: "up regulation of cholesterol transport" EXACT []
synonym: "up-regulation of cholesterol transport" EXACT []
synonym: "upregulation of cholesterol transport" EXACT []
is_a: GO:0032373 ! positive regulation of sterol transport
is_a: GO:0032374 ! regulation of cholesterol transport
relationship: positively_regulates GO:0030301 ! cholesterol transport

[Term]
id: GO:0032377
name: regulation of intracellular lipid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah]
is_a: GO:0032368 ! regulation of lipid transport
is_a: GO:0032386 ! regulation of intracellular transport
relationship: regulates GO:0032365 ! intracellular lipid transport

[Term]
id: GO:0032378
name: negative regulation of intracellular lipid transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah]
synonym: "down regulation of intracellular lipid transport" EXACT []
synonym: "down-regulation of intracellular lipid transport" EXACT []
synonym: "downregulation of intracellular lipid transport" EXACT []
synonym: "inhibition of intracellular lipid transport" NARROW []
is_a: GO:0032369 ! negative regulation of lipid transport
is_a: GO:0032377 ! regulation of intracellular lipid transport
is_a: GO:0032387 ! negative regulation of intracellular transport
relationship: negatively_regulates GO:0032365 ! intracellular lipid transport

[Term]
id: GO:0032379
name: positive regulation of intracellular lipid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah]
synonym: "activation of intracellular lipid transport" NARROW []
synonym: "stimulation of intracellular lipid transport" NARROW []
synonym: "up regulation of intracellular lipid transport" EXACT []
synonym: "up-regulation of intracellular lipid transport" EXACT []
synonym: "upregulation of intracellular lipid transport" EXACT []
is_a: GO:0032370 ! positive regulation of lipid transport
is_a: GO:0032377 ! regulation of intracellular lipid transport
is_a: GO:0032388 ! positive regulation of intracellular transport
relationship: positively_regulates GO:0032365 ! intracellular lipid transport

[Term]
id: GO:0032380
name: regulation of intracellular sterol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah]
is_a: GO:0032371 ! regulation of sterol transport
is_a: GO:0032377 ! regulation of intracellular lipid transport
relationship: regulates GO:0032366 ! intracellular sterol transport

[Term]
id: GO:0032381
name: negative regulation of intracellular sterol transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah]
synonym: "down regulation of intracellular sterol transport" EXACT []
synonym: "down-regulation of intracellular sterol transport" EXACT []
synonym: "downregulation of intracellular sterol transport" EXACT []
synonym: "inhibition of intracellular sterol transport" NARROW []
is_a: GO:0032372 ! negative regulation of sterol transport
is_a: GO:0032378 ! negative regulation of intracellular lipid transport
is_a: GO:0032380 ! regulation of intracellular sterol transport
relationship: negatively_regulates GO:0032366 ! intracellular sterol transport

[Term]
id: GO:0032382
name: positive regulation of intracellular sterol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah]
synonym: "activation of intracellular sterol transport" NARROW []
synonym: "stimulation of intracellular sterol transport" NARROW []
synonym: "up regulation of intracellular sterol transport" EXACT []
synonym: "up-regulation of intracellular sterol transport" EXACT []
synonym: "upregulation of intracellular sterol transport" EXACT []
is_a: GO:0032373 ! positive regulation of sterol transport
is_a: GO:0032379 ! positive regulation of intracellular lipid transport
is_a: GO:0032380 ! regulation of intracellular sterol transport
relationship: positively_regulates GO:0032366 ! intracellular sterol transport

[Term]
id: GO:0032383
name: regulation of intracellular cholesterol transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah]
is_a: GO:0032374 ! regulation of cholesterol transport
is_a: GO:0032380 ! regulation of intracellular sterol transport
relationship: regulates GO:0032367 ! intracellular cholesterol transport

[Term]
id: GO:0032384
name: negative regulation of intracellular cholesterol transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah]
synonym: "down regulation of intracellular cholesterol transport" EXACT []
synonym: "down-regulation of intracellular cholesterol transport" EXACT []
synonym: "downregulation of intracellular cholesterol transport" EXACT []
synonym: "inhibition of intracellular cholesterol transport" NARROW []
is_a: GO:0032375 ! negative regulation of cholesterol transport
is_a: GO:0032381 ! negative regulation of intracellular sterol transport
is_a: GO:0032383 ! regulation of intracellular cholesterol transport
relationship: negatively_regulates GO:0032367 ! intracellular cholesterol transport

[Term]
id: GO:0032385
name: positive regulation of intracellular cholesterol transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah]
synonym: "activation of intracellular cholesterol transport" NARROW []
synonym: "stimulation of intracellular cholesterol transport" NARROW []
synonym: "up regulation of intracellular cholesterol transport" EXACT []
synonym: "up-regulation of intracellular cholesterol transport" EXACT []
synonym: "upregulation of intracellular cholesterol transport" EXACT []
is_a: GO:0032376 ! positive regulation of cholesterol transport
is_a: GO:0032382 ! positive regulation of intracellular sterol transport
is_a: GO:0032383 ! regulation of intracellular cholesterol transport
relationship: positively_regulates GO:0032367 ! intracellular cholesterol transport

[Term]
id: GO:0032386
name: regulation of intracellular transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]
is_a: GO:0051049 ! regulation of transport
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0046907 ! intracellular transport

[Term]
id: GO:0032387
name: negative regulation of intracellular transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]
synonym: "down regulation of intracellular transport" EXACT []
synonym: "down-regulation of intracellular transport" EXACT []
synonym: "downregulation of intracellular transport" EXACT []
synonym: "inhibition of intracellular transport" NARROW []
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0046907 ! intracellular transport

[Term]
id: GO:0032388
name: positive regulation of intracellular transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah]
synonym: "activation of intracellular transport" NARROW []
synonym: "stimulation of intracellular transport" NARROW []
synonym: "up regulation of intracellular transport" EXACT []
synonym: "up-regulation of intracellular transport" EXACT []
synonym: "upregulation of intracellular transport" EXACT []
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0046907 ! intracellular transport

[Term]
id: GO:0032389
name: MutLalpha complex
namespace: cellular_component
def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2." [GOC:vk]
synonym: "MLH1/PMS2 complex" EXACT []
synonym: "MMR complex" BROAD []
synonym: "MutL-alpha complex" EXACT [CORUM:292]
is_a: GO:0032300 ! mismatch repair complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032390
name: MutLbeta complex
namespace: cellular_component
def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1." [GOC:vk]
synonym: "MLH1/PMS1 complex" EXACT []
synonym: "MMR complex" BROAD []
is_a: GO:0032300 ! mismatch repair complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032391
name: photoreceptor connecting cilium
namespace: cellular_component
def: "A 9+0 cilium that forms the portion of the axoneme traversing the boundary between the photoreceptor inner and outer segments." [PMID:15917207, PMID:8718680]
synonym: "photoreceptor cilium" RELATED []
is_a: GO:0031513 ! nonmotile primary cilium

[Term]
id: GO:0032392
name: DNA geometric change
namespace: biological_process
def: "The process by which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases." [GOC:mah]
comment: Note that DNA geometric change and DNA topological change (GO:0006265) are distinct, but are usually coupled in vivo.
subset: goslim_pir
is_a: GO:0071103 ! DNA conformation change

[Term]
id: GO:0032393
name: MHC class I receptor activity
namespace: molecular_function
def: "Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class I protein complexes, not for components of the MHC class I protein complexes themselves.
synonym: "alpha-beta T cell receptor activity" RELATED []
synonym: "gamma-delta T cell receptor activity" RELATED []
synonym: "T cell receptor activity" RELATED []
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0032394
name: MHC class Ib receptor activity
namespace: molecular_function
def: "Combining with an MHC class Ib protein complex to initiate a change in cellular activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class Ib protein complexes, not for components of the MHC class Ib protein complexes themselves.
synonym: "alpha-beta T cell receptor activity" RELATED []
synonym: "gamma-delta T cell receptor activity" RELATED []
synonym: "T cell receptor activity" RELATED []
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0032395
name: MHC class II receptor activity
namespace: molecular_function
def: "Combining with an MHC class II protein complex to initiate a change in cellular activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class II protein complexes, not for components of the MHC class II protein complexes themselves.
synonym: "alpha-beta T cell receptor activity" RELATED []
synonym: "gamma-delta T cell receptor activity" RELATED []
synonym: "T cell receptor activity" RELATED []
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0032396
name: inhibitory MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, PMID:11858820, PMID:9368779, PMID:9597134]
is_a: GO:0032393 ! MHC class I receptor activity

[Term]
id: GO:0032397
name: activating MHC class I receptor activity
namespace: molecular_function
def: "Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte." [GOC:add, PMID:11858820, PMID:9597134]
is_a: GO:0032393 ! MHC class I receptor activity

[Term]
id: GO:0032398
name: MHC class Ib protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15928678]
is_a: GO:0042611 ! MHC protein complex

[Term]
id: GO:0032399
name: HECT domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a HECT, 'Homologous to the E6-AP Carboxyl Terminus', domain of a protein." [GOC:mah, Pfam:PF00632]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0032400
name: melanosome localization
namespace: biological_process
def: "Any process by which a melanosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ln]
is_a: GO:0051875 ! pigment granule localization

[Term]
id: GO:0032401
name: establishment of melanosome localization
namespace: biological_process
def: "The directed movement of a melanosome to a specific location." [GOC:mah]
is_a: GO:0051905 ! establishment of pigment granule localization
relationship: part_of GO:0032400 ! melanosome localization

[Term]
id: GO:0032402
name: melanosome transport
namespace: biological_process
def: "The directed movement of melanosomes into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ln]
is_a: GO:0032401 ! establishment of melanosome localization
is_a: GO:0051904 ! pigment granule transport

[Term]
id: GO:0032403
name: protein complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:mah]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0032404
name: mismatch repair complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mismatch repair complex." [GOC:vk]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0032405
name: MutLalpha complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the mismatch repair complex MutLalpha." [GOC:vk]
is_a: GO:0032404 ! mismatch repair complex binding

[Term]
id: GO:0032406
name: MutLbeta complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the mismatch repair complex MutLbeta." [GOC:vk]
is_a: GO:0032404 ! mismatch repair complex binding

[Term]
id: GO:0032407
name: MutSalpha complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the mismatch repair complex MutSalpha." [GOC:vk]
is_a: GO:0032404 ! mismatch repair complex binding

[Term]
id: GO:0032408
name: MutSbeta complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the mismatch repair complex MutSbeta." [GOC:vk]
is_a: GO:0032404 ! mismatch repair complex binding

[Term]
id: GO:0032409
name: regulation of transporter activity
namespace: biological_process
def: "Any process that modulates the activity of a transporter." [GOC:mah]
subset: gosubset_prok
is_a: GO:0051049 ! regulation of transport
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0032410
name: negative regulation of transporter activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a transporter." [GOC:mah]
synonym: "down regulation of transporter activity" EXACT []
synonym: "down-regulation of transporter activity" EXACT []
synonym: "downregulation of transporter activity" EXACT []
synonym: "inhibition of transporter activity" NARROW []
is_a: GO:0032409 ! regulation of transporter activity
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0051051 ! negative regulation of transport

[Term]
id: GO:0032411
name: positive regulation of transporter activity
namespace: biological_process
def: "Any process that activates or increases the activity of a transporter." [GOC:mah]
synonym: "activation of transporter activity" NARROW []
synonym: "stimulation of transporter activity" NARROW []
synonym: "up regulation of transporter activity" EXACT []
synonym: "up-regulation of transporter activity" EXACT []
synonym: "upregulation of transporter activity" EXACT []
is_a: GO:0032409 ! regulation of transporter activity
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0051050 ! positive regulation of transport

[Term]
id: GO:0032412
name: regulation of ion transmembrane transporter activity
namespace: biological_process
def: "Any process that modulates the activity of an ion transporter." [GOC:mah, GOC:tb]
subset: gosubset_prok
synonym: "regulation of ion transporter activity" EXACT [GOC:tb]
is_a: GO:0022898 ! regulation of transmembrane transporter activity
is_a: GO:0034765 ! regulation of ion transmembrane transport

[Term]
id: GO:0032413
name: negative regulation of ion transmembrane transporter activity
namespace: biological_process
def: "Any process that stops or reduces the activity of an ion transporter." [GOC:mah, GOC:tb]
synonym: "down regulation of ion transporter activity" EXACT []
synonym: "down-regulation of ion transporter activity" EXACT []
synonym: "downregulation of ion transporter activity" EXACT []
synonym: "inhibition of ion transporter activity" NARROW []
synonym: "negative regulation of ion transporter activity" EXACT [GOC:tb]
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity

[Term]
id: GO:0032414
name: positive regulation of ion transmembrane transporter activity
namespace: biological_process
def: "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb]
synonym: "activation of ion transporter activity" NARROW []
synonym: "positive regulation of ion transporter activity" EXACT [GOC:tb]
synonym: "stimulation of ion transporter activity" NARROW []
synonym: "up regulation of ion transporter activity" EXACT []
synonym: "up-regulation of ion transporter activity" EXACT []
synonym: "upregulation of ion transporter activity" EXACT []
is_a: GO:0032411 ! positive regulation of transporter activity
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity

[Term]
id: GO:0032415
name: regulation of sodium:hydrogen antiporter activity
namespace: biological_process
def: "Any process that modulates the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah, GOC:mtg_transport]
synonym: "regulation of sodium:proton antiporter activity" EXACT [GOC:mah]
is_a: GO:0010155 ! regulation of proton transport
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity

[Term]
id: GO:0032416
name: negative regulation of sodium:hydrogen antiporter activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah]
synonym: "down regulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "down-regulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "downregulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "inhibition of sodium:hydrogen antiporter activity" NARROW []
synonym: "negative regulation of sodium:proton antiporter activity" EXACT [GOC:mah]
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:0032415 ! regulation of sodium:hydrogen antiporter activity

[Term]
id: GO:0032417
name: positive regulation of sodium:hydrogen antiporter activity
namespace: biological_process
def: "Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah]
synonym: "activation of sodium:hydrogen antiporter activity" NARROW []
synonym: "positive regulation of sodium:proton antiporter activity" EXACT [GOC:mah]
synonym: "stimulation of sodium:hydrogen antiporter activity" NARROW []
synonym: "up regulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "up-regulation of sodium:hydrogen antiporter activity" EXACT []
synonym: "upregulation of sodium:hydrogen antiporter activity" EXACT []
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:0032415 ! regulation of sodium:hydrogen antiporter activity

[Term]
id: GO:0032418
name: lysosome localization
namespace: biological_process
def: "Any process by which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0032419
name: extrinsic to lysosome membrane
namespace: cellular_component
def: "Loosely bound to one surface of the lysosome membrane, but not integrated into the hydrophobic region." [GOC:mah]
synonym: "extrinsic to lysosomal membrane" EXACT []
is_a: GO:0000306 ! extrinsic to vacuolar membrane
relationship: part_of GO:0005765 ! lysosomal membrane

[Term]
id: GO:0032420
name: stereocilium
namespace: cellular_component
def: "An actin-based protrusion from the apical surface of auditory and vestibular hair cells. Bundles of stereocilia act as mechanosensory organelles." [GOC:ecd, PMID:15661519, PMID:7840137]
is_a: GO:0005902 ! microvillus
is_a: GO:0044422 ! organelle part
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0032421 ! stereocilium bundle

[Term]
id: GO:0032421
name: stereocilium bundle
namespace: cellular_component
def: "An actin-based, cross-linked cellular protrusion on the apical surface of auditory and vestibular hair cells. Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes." [GOC:ecd, PMID:15661519, PMID:7840137]
subset: goslim_pir
synonym: "stereocilia bundle" EXACT []
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0032422
name: purine-rich negative regulatory element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes." [GOC:mah, PMID:9819411]
synonym: "PNR element binding" BROAD []
is_a: GO:0043565 ! sequence-specific DNA binding
is_a: GO:0044212 ! DNA regulatory region binding

[Term]
id: GO:0032423
name: regulation of mismatch repair
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mismatch repair." [GOC:vk]
is_a: GO:0006282 ! regulation of DNA repair
relationship: regulates GO:0006298 ! mismatch repair

[Term]
id: GO:0032424
name: negative regulation of mismatch repair
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mismatch repair." [GOC:vk]
synonym: "down regulation of mismatch repair" EXACT []
synonym: "down-regulation of mismatch repair" EXACT []
synonym: "downregulation of mismatch repair" EXACT []
synonym: "inhibition of mismatch repair" NARROW []
is_a: GO:0032423 ! regulation of mismatch repair
is_a: GO:0045738 ! negative regulation of DNA repair
relationship: negatively_regulates GO:0006298 ! mismatch repair

[Term]
id: GO:0032425
name: positive regulation of mismatch repair
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mismatch repair." [GOC:vk]
synonym: "activation of mismatch repair" NARROW []
synonym: "stimulation of mismatch repair" NARROW []
synonym: "up regulation of mismatch repair" EXACT []
synonym: "up-regulation of mismatch repair" EXACT []
synonym: "upregulation of mismatch repair" EXACT []
is_a: GO:0032423 ! regulation of mismatch repair
is_a: GO:0045739 ! positive regulation of DNA repair
relationship: positively_regulates GO:0006298 ! mismatch repair

[Term]
id: GO:0032426
name: stereocilium bundle tip
namespace: cellular_component
def: "The end of a stereocilium bundle, distal to the site of the bundle's attachment to the apical cell surface." [GOC:ecd, PMID:17021180]
synonym: "stereocilium tip" RELATED []
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0032421 ! stereocilium bundle

[Term]
id: GO:0032427
name: GBD domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the GTPase protein binding domain (GDB) domain of a protein. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac." [GOC:mah, GOC:pg, PMID:9119069]
synonym: "Cdc42/Rac interactive binding motif binding" EXACT [PMID:9119069]
synonym: "CRIB motif binding" EXACT [PMID:9119069]
synonym: "P21-Rho-binding domain binding" EXACT [GOC:rl]
synonym: "PMD binding" EXACT [GOC:rl]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0032428
name: beta-N-acetylgalactosaminidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides." [EC:3.2.1.53]
synonym: "beta-acetylgalactosaminidase activity" EXACT [EC:3.2.1.53]
synonym: "beta-D-N-acetylgalactosaminidase activity" EXACT [EC:3.2.1.53]
synonym: "beta-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity" EXACT [EC:3.2.1.53]
synonym: "N-acetyl-beta-D-galactosaminidase activity" EXACT [EC:3.2.1.53]
synonym: "N-acetyl-beta-galactosaminidase activity" EXACT [EC:3.2.1.53]
synonym: "N-acetylgalactosaminidase activity" EXACT [EC:3.2.1.53]
xref: EC:3.2.1.53
xref: MetaCyc:3.2.1.53-RXN
is_a: GO:0004563 ! beta-N-acetylhexosaminidase activity

[Term]
id: GO:0032429
name: regulation of phospholipase A2 activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme phospholipase A2." [GOC:mah]
is_a: GO:0010517 ! regulation of phospholipase activity

[Term]
id: GO:0032430
name: positive regulation of phospholipase A2 activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme phospholipase A2." [GOC:mah]
synonym: "activation of phospholipase A2 activity" NARROW []
synonym: "stimulation of phospholipase A2 activity" NARROW []
synonym: "up regulation of phospholipase A2 activity" EXACT []
synonym: "up-regulation of phospholipase A2 activity" EXACT []
synonym: "upregulation of phospholipase A2 activity" EXACT []
is_a: GO:0010518 ! positive regulation of phospholipase activity
is_a: GO:0032429 ! regulation of phospholipase A2 activity

[Term]
id: GO:0032431
name: activation of phospholipase A2 activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme phospholipase A2." [GOC:mah]
synonym: "phospholipase A2 activation" EXACT []
is_a: GO:0032430 ! positive regulation of phospholipase A2 activity

[Term]
id: GO:0032432
name: actin filament bundle
namespace: cellular_component
alt_id: GO:0000141
alt_id: GO:0030482
def: "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah]
synonym: "actin cable" RELATED [GOC:mah]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0032433
name: filopodium tip
namespace: cellular_component
def: "The end of a filopodium distal to the body of the cell." [GOC:mah]
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0030175 ! filopodium

[Term]
id: GO:0032434
name: regulation of proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
relationship: regulates GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process

[Term]
id: GO:0032435
name: negative regulation of proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]
synonym: "down regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "down-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "downregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "inhibition of proteasomal ubiquitin-dependent protein catabolic process" NARROW []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:0045861 ! negative regulation of proteolysis
relationship: negatively_regulates GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process

[Term]
id: GO:0032436
name: positive regulation of proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah]
synonym: "activation of proteasomal ubiquitin-dependent protein catabolic process" NARROW []
synonym: "stimulation of proteasomal ubiquitin-dependent protein catabolic process" NARROW []
synonym: "up regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "up-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
synonym: "upregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:0045862 ! positive regulation of proteolysis
relationship: positively_regulates GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process

[Term]
id: GO:0032437
name: cuticular plate
namespace: cellular_component
def: "A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted." [PMID:12485990, PMID:2592408, PMID:8071151]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030864 ! cortical actin cytoskeleton

[Term]
id: GO:0032438
name: melanosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GOC:vk]
synonym: "melanosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0048753 ! pigment granule organization

[Term]
id: GO:0032439
name: endosome localization
namespace: biological_process
def: "Any process by which endosomes are transported to, and/or maintained in, a specific location within the cell." [GOC:ecd]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0032440
name: 2-alkenal reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173]
synonym: "n-alkanal:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.3.1.74]
synonym: "NAD(P)H-dependent alkenal/one oxidoreductase activity" EXACT [EC:1.3.1.74]
synonym: "NADPH:2-alkenal alpha,beta-hydrogenase activity" EXACT []
xref: EC:1.3.1.74
xref: MetaCyc:2-HEXADECENAL-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0032441
name: pheophorbide a oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite (RCC) + oxidized ferredoxin + H2O." [PMID:14657372, PMID:16448336]
xref: EC:1.8.-.-
xref: MetaCyc:RXN-7740
is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors

[Term]
id: GO:0032442
name: phenylcoumaran benzylic ether reductase activity
namespace: molecular_function
def: "Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction dehydrodiconiferyl alcohol + NADPH = isodihydrodehydrodiconiferyl alcohol + NADP." [PMID:11030549, PMID:13129921]
synonym: "PCBER activity" EXACT []
xref: EC:1.1.1.-
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0032443
name: regulation of ergosterol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:mah]
is_a: GO:0050810 ! regulation of steroid biosynthetic process
relationship: regulates GO:0006696 ! ergosterol biosynthetic process

[Term]
id: GO:0032444
name: activin responsive factor complex
namespace: cellular_component
def: "A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor." [PMID:12374795, PMID:9288972]
comment: Note that this term should not be confused with any of the molecular function and biological process terms that refer to the small GTPase ARF (ADP-ribosylation factor).
synonym: "ARF complex" EXACT []
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0032445
name: fructose import
namespace: biological_process
def: "The directed movement of the hexose monosaccharide fructose into a cell or organelle." [GOC:mah]
subset: gosubset_prok
synonym: "fructose uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015755 ! fructose transport

[Term]
id: GO:0032446
name: protein modification by small protein conjugation
namespace: biological_process
def: "A protein modification process by which one or more moieties of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah]
is_a: GO:0070647 ! protein modification by small protein conjugation or removal

[Term]
id: GO:0032447
name: protein urmylation
namespace: biological_process
def: "Covalent attachment of the ubiquitin-like protein URM1 to another protein." [GOC:vw]
is_a: GO:0032446 ! protein modification by small protein conjugation
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0032448
name: DNA hairpin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0000217 ! DNA secondary structure binding

[Term]
id: GO:0032449
name: CBM complex
namespace: cellular_component
def: "A protein complex comprising Carma1, Bcl10 and MALT1; plays a role in signal transduction during NF-kappaB activation." [PMID:12909454]
synonym: "CARMA1-BCL10-Malt1 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0032450
name: maltase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of maltose by an alpha-D-glucosidase-type action." [GOC:pd]
xref: MetaCyc:MALTODEXGLUCOSID-RXN
is_a: GO:0004558 ! alpha-glucosidase activity

[Term]
id: GO:0032451
name: demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a substrate." [GOC:mah]
subset: goslim_pir
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0032452
name: histone demethylase activity
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from a histone." [GOC:mah]
is_a: GO:0032451 ! demethylase activity

[Term]
id: GO:0032453
name: histone demethylase activity (H3-K4 specific)
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein." [GOC:mah]
is_a: GO:0032452 ! histone demethylase activity

[Term]
id: GO:0032454
name: histone demethylase activity (H3-K9 specific)
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from lysine at position 9 of the histone H3 protein." [GOC:mah]
is_a: GO:0032452 ! histone demethylase activity

[Term]
id: GO:0032455
name: nerve growth factor processing
namespace: biological_process
def: "The generation of a mature nerve growth factor by proteolysis of a precursor." [GOC:mah, PMID:8615794]
xref: Reactome:167060 "NGF processing"
xref: Reactome:449229 "NGF processing"
xref: Reactome:470348 "NGF processing"
xref: Reactome:488028 "NGF processing"
xref: Reactome:507989 "NGF processing"
is_a: GO:0016486 ! peptide hormone processing

[Term]
id: GO:0032456
name: endocytic recycling
namespace: biological_process
def: "The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635]
synonym: "retrograde transport of endocytic vesicles" RELATED []
is_a: GO:0016197 ! endosome transport

[Term]
id: GO:0032457
name: fast endocytic recycling
namespace: biological_process
def: "The directed movement of membrane-bounded vesicles from peripheral endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635]
synonym: "direct endocytic recycling" EXACT []
is_a: GO:0032456 ! endocytic recycling

[Term]
id: GO:0032458
name: slow endocytic recycling
namespace: biological_process
def: "The directed movement of membrane-bounded vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635]
is_a: GO:0032456 ! endocytic recycling

[Term]
id: GO:0032459
name: regulation of protein oligomerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein oligomerization." [GOC:mah]
subset: gosubset_prok
is_a: GO:0043254 ! regulation of protein complex assembly
relationship: regulates GO:0051259 ! protein oligomerization

[Term]
id: GO:0032460
name: negative regulation of protein oligomerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein oligomerization." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of protein oligomerization" EXACT []
synonym: "down-regulation of protein oligomerization" EXACT []
synonym: "downregulation of protein oligomerization" EXACT []
synonym: "inhibition of protein oligomerization" NARROW []
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0032459 ! regulation of protein oligomerization
relationship: negatively_regulates GO:0051259 ! protein oligomerization

[Term]
id: GO:0032461
name: positive regulation of protein oligomerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein oligomerization." [GOC:mah]
subset: gosubset_prok
synonym: "activation of protein oligomerization" NARROW []
synonym: "induction of protein oligomerization" RELATED []
synonym: "stimulation of protein oligomerization" NARROW []
synonym: "up regulation of protein oligomerization" EXACT []
synonym: "up-regulation of protein oligomerization" EXACT []
synonym: "upregulation of protein oligomerization" EXACT []
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0032459 ! regulation of protein oligomerization
relationship: positively_regulates GO:0051259 ! protein oligomerization

[Term]
id: GO:0032462
name: regulation of protein homooligomerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein homooligomerization." [GOC:mah]
subset: gosubset_prok
is_a: GO:0032459 ! regulation of protein oligomerization
relationship: regulates GO:0051260 ! protein homooligomerization

[Term]
id: GO:0032463
name: negative regulation of protein homooligomerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein homooligomerization." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of protein homooligomerization" EXACT []
synonym: "down-regulation of protein homooligomerization" EXACT []
synonym: "downregulation of protein homooligomerization" EXACT []
synonym: "inhibition of protein homooligomerization" NARROW []
is_a: GO:0032460 ! negative regulation of protein oligomerization
is_a: GO:0032462 ! regulation of protein homooligomerization
relationship: negatively_regulates GO:0051260 ! protein homooligomerization

[Term]
id: GO:0032464
name: positive regulation of protein homooligomerization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein homooligomerization." [GOC:mah]
subset: gosubset_prok
synonym: "activation of protein homooligomerization" NARROW []
synonym: "induction of protein homooligomerization" RELATED []
synonym: "stimulation of protein homooligomerization" NARROW []
synonym: "up regulation of protein homooligomerization" EXACT []
synonym: "up-regulation of protein homooligomerization" EXACT []
synonym: "upregulation of protein homooligomerization" EXACT []
is_a: GO:0032461 ! positive regulation of protein oligomerization
is_a: GO:0032462 ! regulation of protein homooligomerization
relationship: positively_regulates GO:0051260 ! protein homooligomerization

[Term]
id: GO:0032465
name: regulation of cytokinesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]
is_a: GO:0051302 ! regulation of cell division
relationship: regulates GO:0000910 ! cytokinesis

[Term]
id: GO:0032466
name: negative regulation of cytokinesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokinesis." [GOC:mah]
synonym: "down regulation of cytokinesis" EXACT []
synonym: "down-regulation of cytokinesis" EXACT []
synonym: "downregulation of cytokinesis" EXACT []
synonym: "inhibition of cytokinesis" NARROW []
is_a: GO:0032465 ! regulation of cytokinesis
is_a: GO:0051782 ! negative regulation of cell division
relationship: negatively_regulates GO:0000910 ! cytokinesis

[Term]
id: GO:0032467
name: positive regulation of cytokinesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytokinesis." [GOC:mah]
synonym: "activation of cytokinesis" NARROW []
synonym: "stimulation of cytokinesis" NARROW []
synonym: "up regulation of cytokinesis" EXACT []
synonym: "up-regulation of cytokinesis" EXACT []
synonym: "upregulation of cytokinesis" EXACT []
is_a: GO:0032465 ! regulation of cytokinesis
is_a: GO:0051781 ! positive regulation of cell division
relationship: positively_regulates GO:0000910 ! cytokinesis

[Term]
id: GO:0032468
name: Golgi calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings." [GOC:mah]
synonym: "calcium ion homeostasis in Golgi" EXACT []
synonym: "Golgi calcium ion concentration regulation" EXACT []
synonym: "regulation of calcium ion concentration in Golgi" EXACT []
synonym: "regulation of Golgi calcium ion concentration" EXACT []
is_a: GO:0006874 ! cellular calcium ion homeostasis

[Term]
id: GO:0032469
name: endoplasmic reticulum calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah]
synonym: "calcium ion homeostasis in endoplasmic reticulum" EXACT []
synonym: "calcium ion homeostasis in ER" EXACT []
synonym: "endoplasmic reticulum calcium ion concentration regulation" EXACT []
synonym: "ER calcium ion concentration regulation" EXACT []
synonym: "ER calcium ion homeostasis" EXACT []
synonym: "regulation of calcium ion concentration in endoplasmic reticulum" EXACT []
synonym: "regulation of calcium ion concentration in ER" EXACT []
synonym: "regulation of endoplasmic reticulum calcium ion concentration" EXACT []
synonym: "regulation of ER calcium ion concentration" EXACT []
is_a: GO:0006874 ! cellular calcium ion homeostasis

[Term]
id: GO:0032470
name: elevation of endoplasmic reticulum calcium ion concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah]
synonym: "elevation of calcium ion concentration in endoplasmic reticulum" EXACT []
synonym: "elevation of ER calcium ion concentration" EXACT []
synonym: "endoplasmic reticulum calcium ion concentration elevation" EXACT []
is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis

[Term]
id: GO:0032471
name: reduction of endoplasmic reticulum calcium ion concentration
namespace: biological_process
def: "Any process that decreases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah]
synonym: "endoplasmic reticulum calcium ion concentration reduction" EXACT []
synonym: "ER calcium ion concentration reduction" EXACT []
synonym: "reduction of calcium ion concentration in endoplasmic reticulum" EXACT []
synonym: "reduction of calcium ion concentration in ER" EXACT []
synonym: "reduction of ER calcium ion concentration" EXACT []
is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis

[Term]
id: GO:0032472
name: Golgi calcium ion transport
namespace: biological_process
def: "The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus." [GOC:mah]
synonym: "Golgi calcium transport" EXACT []
is_a: GO:0006816 ! calcium ion transport
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0032473
name: external side of mitochondrial outer membrane
namespace: cellular_component
def: "The external (cytoplasmic face) of the mitochondrial outer membrane." [GOC:mah]
synonym: "cytosolic side of mitochondrial outer membrane" EXACT []
synonym: "external side of mitochondrial envelope" RELATED []
is_a: GO:0044455 ! mitochondrial membrane part

[Term]
id: GO:0032474
name: otolith morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of an otolith are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dgh]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0048840 ! otolith development

[Term]
id: GO:0032475
name: otolith formation
namespace: biological_process
def: "The process that gives rise to an otolith. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dgh]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0032474 ! otolith morphogenesis

[Term]
id: GO:0032476
name: decaprenyl diphosphate synthase complex
namespace: cellular_component
def: "A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [GOC:mah, PMID:14519123]
subset: goslim_pir
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0032477
name: homodimeric decaprenyl diphosphate synthase complex
namespace: cellular_component
def: "A homodimeric complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [PMID:14519123]
is_a: GO:0032476 ! decaprenyl diphosphate synthase complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0032478
name: heterotetrameric decaprenyl diphosphate synthase complex
namespace: cellular_component
def: "A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1." [PMID:14519123]
is_a: GO:0032476 ! decaprenyl diphosphate synthase complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0032479
name: regulation of type I interferon production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah]
synonym: "regulation of type I IFN production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032606 ! type I interferon production

[Term]
id: GO:0032480
name: negative regulation of type I interferon production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah]
synonym: "down regulation of type I interferon production" EXACT []
synonym: "down-regulation of type I interferon production" EXACT []
synonym: "downregulation of type I interferon production" EXACT []
synonym: "inhibition of type I interferon production" NARROW []
synonym: "negative regulation of type I IFN production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032479 ! regulation of type I interferon production
relationship: negatively_regulates GO:0032606 ! type I interferon production

[Term]
id: GO:0032481
name: positive regulation of type I interferon production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah]
synonym: "activation of type I interferon production" NARROW []
synonym: "stimulation of type I interferon production" NARROW []
synonym: "up regulation of type I interferon production" EXACT []
synonym: "up-regulation of type I interferon production" EXACT []
synonym: "upregulation of type I interferon production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032479 ! regulation of type I interferon production
relationship: positively_regulates GO:0032606 ! type I interferon production

[Term]
id: GO:0032482
name: Rab protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state." [GOC:mah]
is_a: GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0032483
name: regulation of Rab protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah]
is_a: GO:0046578 ! regulation of Ras protein signal transduction
relationship: regulates GO:0032482 ! Rab protein signal transduction

[Term]
id: GO:0032484
name: Ral protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state." [GOC:mah]
is_a: GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0032485
name: regulation of Ral protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Ral protein signal transduction." [GOC:mah]
is_a: GO:0046578 ! regulation of Ras protein signal transduction
relationship: regulates GO:0032484 ! Ral protein signal transduction

[Term]
id: GO:0032486
name: Rap protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state." [GOC:mah]
is_a: GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0032487
name: regulation of Rap protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Rap protein signal transduction." [GOC:mah]
is_a: GO:0046578 ! regulation of Ras protein signal transduction
relationship: regulates GO:0032486 ! Rap protein signal transduction

[Term]
id: GO:0032488
name: Cdc42 protein signal transduction
namespace: biological_process
def: "A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state." [GOC:mah]
is_a: GO:0007266 ! Rho protein signal transduction

[Term]
id: GO:0032489
name: regulation of Cdc42 protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction." [GOC:mah]
is_a: GO:0035023 ! regulation of Rho protein signal transduction
relationship: regulates GO:0032488 ! Cdc42 protein signal transduction

[Term]
id: GO:0032490
name: detection of molecule of bacterial origin
namespace: biological_process
def: "The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal." [GOC:add, GOC:rl]
synonym: "detection of bacteria associated molecule" EXACT []
synonym: "detection of bacterial associated molecule" EXACT []
synonym: "detection of bacterium associated molecule" EXACT []
is_a: GO:0002237 ! response to molecule of bacterial origin
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0032491
name: detection of molecule of fungal origin
namespace: biological_process
def: "The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal." [GOC:mah, GOC:rl]
synonym: "detection of fungal associated molecule" EXACT []
synonym: "detection of fungus associated molecule" EXACT []
is_a: GO:0002238 ! response to molecule of fungal origin
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0032492
name: detection of molecule of oomycetes origin
namespace: biological_process
def: "The series of events in which a stimulus from a molecule of oomycetes origin is received and converted into a molecular signal." [GOC:mah, GOC:rl]
synonym: "detection of oomycetes associated molecule" EXACT []
is_a: GO:0002240 ! response to molecule of oomycetes origin
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0032493
name: response to bacterial lipoprotein
namespace: biological_process
def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus." [GOC:add, PMID:12077222]
is_a: GO:0002237 ! response to molecule of bacterial origin

[Term]
id: GO:0032494
name: response to peptidoglycan
namespace: biological_process
def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464]
is_a: GO:0002237 ! response to molecule of bacterial origin

[Term]
id: GO:0032495
name: response to muramyl dipeptide
namespace: biological_process
def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:add]
is_a: GO:0032494 ! response to peptidoglycan

[Term]
id: GO:0032496
name: response to lipopolysaccharide
namespace: biological_process
def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, ISBN:0721601464]
synonym: "response to endotoxin" BROAD [GOC:sl]
synonym: "response to LPS" EXACT []
is_a: GO:0002237 ! response to molecule of bacterial origin

[Term]
id: GO:0032497
name: detection of lipopolysaccharide
namespace: biological_process
def: "The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, PMID:15998797]
synonym: "detection of LPS" EXACT []
is_a: GO:0032490 ! detection of molecule of bacterial origin
is_a: GO:0032496 ! response to lipopolysaccharide

[Term]
id: GO:0032498
name: detection of muramyl dipeptide
namespace: biological_process
def: "The series of events in which a muramyl dipeptide stimulus is received by a cell and converted into a molecular signal. Muramyl dipeptide is derived from peptidoglycan." [GOC:rl, PMID:15998797]
is_a: GO:0032495 ! response to muramyl dipeptide
is_a: GO:0032499 ! detection of peptidoglycan

[Term]
id: GO:0032499
name: detection of peptidoglycan
namespace: biological_process
def: "The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464]
is_a: GO:0032490 ! detection of molecule of bacterial origin
is_a: GO:0032494 ! response to peptidoglycan

[Term]
id: GO:0032500
name: muramyl dipeptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan." [GOC:rl]
is_a: GO:0042834 ! peptidoglycan binding

[Term]
id: GO:0032501
name: multicellular organismal process
namespace: biological_process
alt_id: GO:0050874
def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]
subset: goslim_goa
subset: goslim_pir
synonym: "organismal physiological process" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0032502
name: developmental process
namespace: biological_process
def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete]
subset: goslim_pir
subset: gosubset_prok
synonym: "development" NARROW []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0032504
name: multicellular organism reproduction
namespace: biological_process
def: "The biological process by which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jic]
is_a: GO:0000003 ! reproduction
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0032505
name: reproduction of a single-celled organism
namespace: biological_process
def: "The biological process in which new individuals are produced by one or two single-celled organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete]
subset: gosubset_prok
is_a: GO:0000003 ! reproduction

[Term]
id: GO:0032506
name: cytokinetic process
namespace: biological_process
def: "A cellular process that is involved in the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:isa_complete, GOC:mah]
subset: gosubset_prok
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0000910 ! cytokinesis

[Term]
id: GO:0032507
name: maintenance of protein location in cell
namespace: biological_process
def: "Any process by which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah]
synonym: "maintenance of protein localization in cell" RELATED [GOC:dph, GOC:tb]
is_a: GO:0045185 ! maintenance of protein location
is_a: GO:0051651 ! maintenance of location in cell

[Term]
id: GO:0032508
name: DNA duplex unwinding
namespace: biological_process
def: "The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah]
comment: Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'.
synonym: "DNA unwinding" EXACT []
synonym: "duplex DNA melting" EXACT []
is_a: GO:0032392 ! DNA geometric change

[Term]
id: GO:0032509
name: endosome transport via multivesicular body sorting pathway
namespace: biological_process
def: "The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637]
synonym: "endosome transport via MVB sorting pathway" EXACT []
is_a: GO:0016197 ! endosome transport

[Term]
id: GO:0032510
name: endosome to lysosome transport via multivesicular body sorting pathway
namespace: biological_process
def: "The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome." [GOC:mah, PMID:12461556, PMID:16689637]
synonym: "endosome to lysosome transport via MVB sorting pathway" EXACT []
is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway
is_a: GO:0045022 ! early endosome to late endosome transport

[Term]
id: GO:0032511
name: late endosome to vacuole transport via multivesicular body sorting pathway
namespace: biological_process
def: "The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637]
synonym: "endosome to vacuole transport via MVB sorting pathway" EXACT []
is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway
is_a: GO:0045324 ! late endosome to vacuole transport

[Term]
id: GO:0032512
name: regulation of protein phosphatase type 2B activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme protein phosphatase type 2B." [GOC:mah]
synonym: "regulation of calcineurin activity" EXACT []
is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity

[Term]
id: GO:0032513
name: negative regulation of protein phosphatase type 2B activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme protein phosphatase type 2B." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of protein phosphatase type 2B activity" EXACT []
synonym: "down-regulation of protein phosphatase type 2B activity" EXACT []
synonym: "downregulation of protein phosphatase type 2B activity" EXACT []
synonym: "inhibition of protein phosphatase type 2B activity" NARROW []
synonym: "negative regulation of calcineurin activity" EXACT []
is_a: GO:0032512 ! regulation of protein phosphatase type 2B activity
is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity

[Term]
id: GO:0032514
name: positive regulation of protein phosphatase type 2B activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme protein phosphatase type 2B." [GOC:mah]
subset: gosubset_prok
synonym: "activation of protein phosphatase type 2B activity" NARROW []
synonym: "calcineurin activation" EXACT []
synonym: "positive regulation of calcineurin activity" EXACT []
synonym: "stimulation of protein phosphatase type 2B activity" NARROW []
synonym: "up regulation of protein phosphatase type 2B activity" EXACT []
synonym: "up-regulation of protein phosphatase type 2B activity" EXACT []
synonym: "upregulation of protein phosphatase type 2B activity" EXACT []
is_a: GO:0032512 ! regulation of protein phosphatase type 2B activity
is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity

[Term]
id: GO:0032515
name: negative regulation of phosphoprotein phosphatase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a phosphoprotein phosphatase." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of phosphoprotein phosphatase activity" EXACT []
synonym: "down-regulation of phosphoprotein phosphatase activity" EXACT []
synonym: "downregulation of phosphoprotein phosphatase activity" EXACT []
synonym: "inhibition of phosphoprotein phosphatase activity" NARROW []
is_a: GO:0010923 ! negative regulation of phosphatase activity
is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity
is_a: GO:0051004 ! regulation of lipoprotein lipase activity

[Term]
id: GO:0032516
name: positive regulation of phosphoprotein phosphatase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a phosphoprotein phosphatase." [GOC:mah]
subset: gosubset_prok
synonym: "activation of phosphoprotein phosphatase activity" NARROW []
synonym: "stimulation of phosphoprotein phosphatase activity" NARROW []
synonym: "up regulation of phosphoprotein phosphatase activity" EXACT []
synonym: "up-regulation of phosphoprotein phosphatase activity" EXACT []
synonym: "upregulation of phosphoprotein phosphatase activity" EXACT []
is_a: GO:0010922 ! positive regulation of phosphatase activity
is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity
is_a: GO:0051004 ! regulation of lipoprotein lipase activity

[Term]
id: GO:0032517
name: SOD1-calcineurin complex
namespace: cellular_component
def: "A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1." [GOC:mah, PMID:17324120]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0032518
name: amino acid-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(in) = ADP + phosphate + amino acid(out)." [GOC:mah]
is_a: GO:0015424 ! amino acid-transporting ATPase activity

[Term]
id: GO:0032519
name: cysteine-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(in) = ADP + phosphate + cysteine(out)." [GOC:mah]
synonym: "cysteine exporter" RELATED []
is_a: GO:0032518 ! amino acid-exporting ATPase activity
is_a: GO:0033230 ! cysteine-transporting ATPase activity

[Term]
id: GO:0032520
name: amino acid-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out) = ADP + phosphate + amino acid(in)." [GOC:mah]
is_a: GO:0015424 ! amino acid-transporting ATPase activity

[Term]
id: GO:0032521
name: D-methionine-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(in) = ADP + phosphate + D-methionine(out)." [GOC:mah]
synonym: "D-methionine exporter" RELATED []
is_a: GO:0032518 ! amino acid-exporting ATPase activity
is_a: GO:0033232 ! D-methionine-transporting ATPase activity

[Term]
id: GO:0032522
name: D-methionine-importing ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out) = ADP + phosphate + D-methionine(in)." [GOC:mah]
synonym: "D-methionine importer" RELATED []
is_a: GO:0032520 ! amino acid-importing ATPase activity
is_a: GO:0033232 ! D-methionine-transporting ATPase activity

[Term]
id: GO:0032523
name: silicon efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of silicon from the inside of the cell to the outside of the cell across a membrane." [GOC:mah, PMID:17625566]
synonym: "silicon efflux transporter activity" EXACT []
is_a: GO:0005351 ! sugar:hydrogen symporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity
is_a: GO:0042900 ! arabinose transmembrane transporter activity

[Term]
id: GO:0032524
name: nutrient export
namespace: biological_process
def: "OBSOLETE. The directed movement of nutrients out of a cell or organelle." [GOC:mah]
comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning.
subset: gosubset_prok
is_obsolete: true
consider: GO:0006810

[Term]
id: GO:0032525
name: somite rostral/caudal axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary." [GOC:bf, PMID:16326386, PMID:17360776]
synonym: "somite rostrocaudal axis specification" EXACT []
synonym: "somite rostrocaudal polarity" RELATED []
is_a: GO:0000578 ! embryonic axis specification
is_a: GO:0009948 ! anterior/posterior axis specification
relationship: part_of GO:0001756 ! somitogenesis

[Term]
id: GO:0032526
name: response to retinoic acid
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:sl]
synonym: "response to vitamin A acid" EXACT []
is_a: GO:0033189 ! response to vitamin A

[Term]
id: GO:0032527
name: protein exit from endoplasmic reticulum
namespace: biological_process
def: "The directed movement of proteins from the endoplasmic reticulum." [GOC:rb]
synonym: "protein exit from ER" EXACT []
synonym: "protein export from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "protein export from ER" EXACT [GOC:mah]
is_a: GO:0006886 ! intracellular protein transport

[Term]
id: GO:0032528
name: microvillus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah]
synonym: "microvillus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0032529
name: follicle cell microvillus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. A microvillus is a thin cylindrical membrane-covered projection on the surface of an animal cell containing a core bundle of actin filaments." [GOC:sart, PMID:16507588]
synonym: "follicle cell microvillus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0032528 ! microvillus organization

[Term]
id: GO:0032530
name: regulation of microvillus organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus." [GOC:mah]
synonym: "regulation of microvillus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0031344 ! regulation of cell projection organization
relationship: regulates GO:0032528 ! microvillus organization

[Term]
id: GO:0032531
name: regulation of follicle cell microvillus organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell." [GOC:mah]
synonym: "regulation of follicle cell microvillus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0032530 ! regulation of microvillus organization
relationship: regulates GO:0032529 ! follicle cell microvillus organization

[Term]
id: GO:0032532
name: regulation of microvillus length
namespace: biological_process
def: "A process that modulates the length of a microvillus." [GOC:mah]
is_a: GO:0032530 ! regulation of microvillus organization
is_a: GO:0032536 ! regulation of cell projection size

[Term]
id: GO:0032533
name: regulation of follicle cell microvillus length
namespace: biological_process
def: "A process that modulates the length of a microvillus on a follicle cell." [GOC:sart, PMID:16260500]
is_a: GO:0032531 ! regulation of follicle cell microvillus organization
is_a: GO:0032532 ! regulation of microvillus length

[Term]
id: GO:0032534
name: regulation of microvillus assembly
namespace: biological_process
def: "A process that modulates the formation of a microvillus." [GOC:mah]
synonym: "regulation of microvillus biogenesis" RELATED [GOC:mah]
is_a: GO:0032530 ! regulation of microvillus organization
is_a: GO:0060491 ! regulation of cell projection assembly
relationship: regulates GO:0030033 ! microvillus assembly

[Term]
id: GO:0032535
name: regulation of cellular component size
namespace: biological_process
def: "A process that modulates the size of a cellular component." [GOC:mah]
subset: gosubset_prok
is_a: GO:0090066 ! regulation of anatomical structure size

[Term]
id: GO:0032536
name: regulation of cell projection size
namespace: biological_process
def: "A process that modulates the size of a cell projection." [GOC:mah]
is_a: GO:0032535 ! regulation of cellular component size

[Term]
id: GO:0032537
name: host-seeking behavior
namespace: biological_process
def: "The specific actions or reactions of an organism that are associated with finding a host organism; may include behavioral responses to light, temperature, or chemical emanations from the prospective host." [GOC:mah, PMID:11931033]
synonym: "host-seeking behaviour" EXACT []
is_a: GO:0007610 ! behavior

[Term]
id: GO:0032538
name: regulation of host-seeking behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah]
synonym: "regulation of host-seeking behaviour" EXACT []
is_a: GO:0050795 ! regulation of behavior
relationship: regulates GO:0032537 ! host-seeking behavior

[Term]
id: GO:0032539
name: negative regulation of host-seeking behavior
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah]
synonym: "down regulation of host-seeking behavior" EXACT []
synonym: "down-regulation of host-seeking behavior" EXACT []
synonym: "downregulation of host-seeking behavior" EXACT []
synonym: "inhibition of host-seeking behavior" NARROW []
synonym: "negative regulation of host-seeking behaviour" EXACT []
is_a: GO:0032538 ! regulation of host-seeking behavior
is_a: GO:0048521 ! negative regulation of behavior
relationship: negatively_regulates GO:0032537 ! host-seeking behavior

[Term]
id: GO:0032540
name: positive regulation of host-seeking behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah]
synonym: "activation of host-seeking behavior" NARROW []
synonym: "positive regulation of host-seeking behaviour" EXACT []
synonym: "stimulation of host-seeking behavior" NARROW []
synonym: "up regulation of host-seeking behavior" EXACT []
synonym: "up-regulation of host-seeking behavior" EXACT []
synonym: "upregulation of host-seeking behavior" EXACT []
is_a: GO:0032538 ! regulation of host-seeking behavior
is_a: GO:0048520 ! positive regulation of behavior
relationship: positively_regulates GO:0032537 ! host-seeking behavior

[Term]
id: GO:0032541
name: cortical endoplasmic reticulum
namespace: cellular_component
def: "A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements." [GOC:se, PMID:10931860, PMID:17686782]
synonym: "cortical ER" EXACT []
synonym: "peripheral endoplasmic reticulum" EXACT []
synonym: "peripheral ER" EXACT []
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0032542
name: sulfiredoxin activity
namespace: molecular_function
def: "Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH <=> peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R." [EC:1.8.98.2]
synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase activity" EXACT []
synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]" RELATED [EC:1.8.98.2]
synonym: "Srx1" RELATED [EC:1.8.98.2]
synonym: "sulphiredoxin activity" EXACT []
xref: EC:1.8.98.2
xref: MetaCyc:1.8.98.2-RXN
is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors

[Term]
id: GO:0032543
name: mitochondrial translation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]
synonym: "mitochondrial protein anabolism" EXACT []
synonym: "mitochondrial protein biosynthesis" EXACT []
synonym: "mitochondrial protein formation" EXACT []
synonym: "mitochondrial protein synthesis" EXACT []
synonym: "mitochondrial protein translation" EXACT []
is_a: GO:0006412 ! translation
is_a: GO:0007005 ! mitochondrion organization

[Term]
id: GO:0032544
name: plastid translation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators]
synonym: "plastid protein anabolism" EXACT []
synonym: "plastid protein biosynthesis" EXACT []
synonym: "plastid protein formation" EXACT []
synonym: "plastid protein synthesis" EXACT []
synonym: "plastid protein translation" EXACT []
is_a: GO:0006412 ! translation
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0032545
name: CURI complex
namespace: cellular_component
def: "A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p andIfh1p." [PMID:17452446]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032546
name: deoxyribonucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001882 ! nucleoside binding

[Term]
id: GO:0032547
name: purine deoxyribonucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001883 ! purine nucleoside binding
is_a: GO:0032546 ! deoxyribonucleoside binding

[Term]
id: GO:0032548
name: pyrimidine deoxyribonucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001884 ! pyrimidine nucleoside binding
is_a: GO:0032546 ! deoxyribonucleoside binding

[Term]
id: GO:0032549
name: ribonucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001882 ! nucleoside binding

[Term]
id: GO:0032550
name: purine ribonucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a purine ribonucleoside, a compound consisting of a purine base linked to ribose." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001883 ! purine nucleoside binding
is_a: GO:0032549 ! ribonucleoside binding

[Term]
id: GO:0032551
name: pyrimidine ribonucleoside binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001884 ! pyrimidine nucleoside binding
is_a: GO:0032549 ! ribonucleoside binding

[Term]
id: GO:0032552
name: deoxyribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0032553
name: ribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0000166 ! nucleotide binding

[Term]
id: GO:0032554
name: purine deoxyribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a purine deoxyribonucleotide, any compound consisting of a purine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0017076 ! purine nucleotide binding
is_a: GO:0032552 ! deoxyribonucleotide binding

[Term]
id: GO:0032555
name: purine ribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0017076 ! purine nucleotide binding
is_a: GO:0032553 ! ribonucleotide binding

[Term]
id: GO:0032556
name: pyrimidine deoxyribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0019103 ! pyrimidine nucleotide binding
is_a: GO:0032552 ! deoxyribonucleotide binding

[Term]
id: GO:0032557
name: pyrimidine ribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0019103 ! pyrimidine nucleotide binding
is_a: GO:0032553 ! ribonucleotide binding

[Term]
id: GO:0032558
name: adenyl deoxyribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030554 ! adenyl nucleotide binding
is_a: GO:0032554 ! purine deoxyribonucleotide binding

[Term]
id: GO:0032559
name: adenyl ribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030554 ! adenyl nucleotide binding
is_a: GO:0032555 ! purine ribonucleotide binding

[Term]
id: GO:0032560
name: guanyl deoxyribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0019001 ! guanyl nucleotide binding
is_a: GO:0032554 ! purine deoxyribonucleotide binding

[Term]
id: GO:0032561
name: guanyl ribonucleotide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0019001 ! guanyl nucleotide binding
is_a: GO:0032555 ! purine ribonucleotide binding

[Term]
id: GO:0032562
name: dAMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dAMP, deoxyadenosine monophosphate." [GOC:mah]
is_a: GO:0032558 ! adenyl deoxyribonucleotide binding

[Term]
id: GO:0032563
name: dADP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dADP, deoxyadenosine diphosphate." [GOC:mah]
is_a: GO:0032558 ! adenyl deoxyribonucleotide binding

[Term]
id: GO:0032564
name: dATP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dATP, deoxyadenosine triphosphate." [GOC:mah]
is_a: GO:0032558 ! adenyl deoxyribonucleotide binding

[Term]
id: GO:0032565
name: dGMP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dGMP, deoxyguanosine monophosphate." [GOC:mah]
is_a: GO:0032560 ! guanyl deoxyribonucleotide binding

[Term]
id: GO:0032566
name: dGDP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dGDP, deoxyguanosine diphosphate." [GOC:mah]
is_a: GO:0032560 ! guanyl deoxyribonucleotide binding

[Term]
id: GO:0032567
name: dGTP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dGTP, deoxyguanosine triphosphate." [GOC:mah]
is_a: GO:0032560 ! guanyl deoxyribonucleotide binding

[Term]
id: GO:0032568
name: general transcription from RNA polymerase II promoter
namespace: biological_process
def: "The basal, non-specifically regulated synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Mediated by core RNA polymerase II and a set of general transcription factors; in Saccharomyces five transcription factors are necessary and sufficient for such basal transcription." [GOC:mah]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter

[Term]
id: GO:0032569
name: gene-specific transcription from RNA polymerase II promoter
namespace: biological_process
def: "The specifically regulated synthesis of RNA from DNA encoding a specific gene or set of genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. In addition to RNA polymerase II and the general transcription factors, specific transcription requires one or more specific factors that bind to specific DNA sequences or interact with the general transcription machinery." [GOC:mah]
subset: goslim_pombe
synonym: "specific transcription from RNA polymerase II promoter" EXACT [GOC:mah]
is_a: GO:0006366 ! transcription from RNA polymerase II promoter

[Term]
id: GO:0032570
name: response to progesterone stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:sl]
is_a: GO:0048545 ! response to steroid hormone stimulus

[Term]
id: GO:0032571
name: response to vitamin K
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus." [GOC:sl]
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0032572
name: response to menaquinone
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus." [GOC:sl]
synonym: "response to menatetrenone" EXACT []
synonym: "response to vitamin K2" EXACT []
is_a: GO:0032571 ! response to vitamin K

[Term]
id: GO:0032573
name: response to phylloquinone
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:sl]
synonym: "response to vitamin K1" EXACT []
is_a: GO:0032571 ! response to vitamin K

[Term]
id: GO:0032574
name: 5'-3' RNA helicase activity
namespace: molecular_function
def: "Catalysis of the unwinding of an RNA helix in the direction 5' to 3'." [GOC:jp]
synonym: "5' to 3' RNA helicase activity" EXACT []
is_a: GO:0003724 ! RNA helicase activity

[Term]
id: GO:0032575
name: ATP-dependent 5'-3' RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of an RNA helix in the direction 5' to 3'." [GOC:jp]
synonym: "ATP-dependent 5' to 3' RNA helicase activity" EXACT []
is_a: GO:0004004 ! ATP-dependent RNA helicase activity
is_a: GO:0032574 ! 5'-3' RNA helicase activity

[Term]
id: GO:0032576
name: O-linoleoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group to an oxygen atom on the acceptor molecule." [GOC:cb]
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0032577
name: phosphatidylcholine:cardiolipin O-linoleoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule." [GOC:cb, GOC:mah]
synonym: "phosphatidylcholine:cardiolipin linoleoyltransferase" EXACT []
is_a: GO:0032576 ! O-linoleoyltransferase activity

[Term]
id: GO:0032578
name: aleurone grain membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an aleurone grain." [GOC:ecd]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0033095 ! aleurone grain

[Term]
id: GO:0032579
name: apical lamina of hyaline layer
namespace: cellular_component
def: "A fibrous network that is part of the hyalin layer extracellular matrix. The apical lamina is thought to be principally composed of the glycoproteins fibropellins. This matrix has been found in echinoderms." [GOC:ecd, PMID:2060714, PMID:7608987, PMID:9638331]
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0033166 ! hyaline layer

[Term]
id: GO:0032580
name: Golgi cisterna membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah]
synonym: "Golgi stack membrane" EXACT []
is_a: GO:0000139 ! Golgi membrane
relationship: part_of GO:0031985 ! Golgi cisterna

[Term]
id: GO:0032581
name: ER-dependent peroxisome organization
namespace: biological_process
def: "A process of peroxisome organization in which assembly or arrangement of constituent parts takes place in the endoplasmic reticulum." [GOC:mah, PMID:16717127, PMID:17646399]
synonym: "endoplasmic reticulum-dependent peroxisome organization" EXACT [GOC:mah]
synonym: "ER-dependent peroxisome biogenesis" RELATED [GOC:mah]
synonym: "ER-dependent peroxisome organisation" EXACT [GOC:mah]
is_a: GO:0007031 ! peroxisome organization

[Term]
id: GO:0032582
name: negative regulation of gene-specific transcription
namespace: biological_process
def: "Any process that stops, prevents or reduces the DNA-dependent transcription of a specific gene or genes." [GOC:mah]
synonym: "down regulation of gene-specific transcription" EXACT []
synonym: "down-regulation of gene-specific transcription" EXACT []
synonym: "downregulation of gene-specific transcription" EXACT []
synonym: "inhibition of gene-specific transcription" NARROW []
is_a: GO:0032583 ! regulation of gene-specific transcription
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent

[Term]
id: GO:0032583
name: regulation of gene-specific transcription
namespace: biological_process
def: "Any process that modulates the DNA-dependent transcription of a specific gene or genes." [GOC:mah]
is_a: GO:0006355 ! regulation of transcription, DNA-dependent

[Term]
id: GO:0032584
name: growth cone membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a growth cone." [GOC:mah]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0030426 ! growth cone

[Term]
id: GO:0032585
name: multivesicular body membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a multivesicular body." [GOC:mah]
synonym: "multivesicular endosome membrane" EXACT []
synonym: "MVB membrane" EXACT []
synonym: "MVE membrane" EXACT []
is_a: GO:0031902 ! late endosome membrane
relationship: part_of GO:0005771 ! multivesicular body

[Term]
id: GO:0032586
name: protein storage vacuole membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a protein storage vacuole." [GOC:mah]
is_a: GO:0009705 ! plant-type vacuole membrane

[Term]
id: GO:0032587
name: ruffle membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a ruffle." [GOC:mah]
synonym: "membrane ruffle" RELATED []
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0031256 ! leading edge membrane
relationship: part_of GO:0001726 ! ruffle

[Term]
id: GO:0032588
name: trans-Golgi network membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah]
synonym: "Golgi trans face membrane" RELATED []
synonym: "trans Golgi network membrane" EXACT []
is_a: GO:0000139 ! Golgi membrane
relationship: part_of GO:0005802 ! trans-Golgi network

[Term]
id: GO:0032589
name: neuron projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a neuron projection." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0031256 ! leading edge membrane
relationship: part_of GO:0043005 ! neuron projection

[Term]
id: GO:0032590
name: dendrite membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a dendrite." [GOC:mah]
is_a: GO:0032589 ! neuron projection membrane

[Term]
id: GO:0032591
name: dendritic spine membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a dendritic spine." [GOC:mah]
is_a: GO:0032589 ! neuron projection membrane
relationship: part_of GO:0043197 ! dendritic spine

[Term]
id: GO:0032592
name: integral to mitochondrial membrane
namespace: cellular_component
def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of a mitochondrial membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031301 ! integral to organelle membrane
is_a: GO:0044455 ! mitochondrial membrane part

[Term]
id: GO:0032593
name: insulin-responsive compartment
namespace: cellular_component
def: "A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2." [PMID:17644329]
synonym: "GLUT4 storage compartment" EXACT []
synonym: "GSC" RELATED []
synonym: "IRC" RELATED []
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0032594
name: protein transport within lipid bilayer
namespace: biological_process
def: "The directed movement of a protein from one location to another within a lipid bilayer." [GOC:mah]
synonym: "protein translocation within membrane" EXACT []
synonym: "receptor translocation within membrane" NARROW []
synonym: "receptor transport within lipid bilayer" NARROW []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0016044 ! cellular membrane organization

[Term]
id: GO:0032595
name: B cell receptor transport within lipid bilayer
namespace: biological_process
def: "The directed movement of a B cell receptor within a lipid bilayer." [GOC:mah]
synonym: "B cell receptor translocation within membrane" EXACT []
synonym: "BCR translocation within membrane" EXACT []
synonym: "BCR transport within lipid bilayer" EXACT []
is_a: GO:0032594 ! protein transport within lipid bilayer

[Term]
id: GO:0032596
name: protein transport into membrane raft
namespace: biological_process
def: "The directed movement of a protein into a membrane raft." [GOC:mah]
synonym: "protein translocation into membrane raft" EXACT []
synonym: "protein transport into lipid raft" EXACT []
synonym: "receptor translocation into membrane raft" NARROW []
synonym: "receptor transport into membrane raft" NARROW []
is_a: GO:0032594 ! protein transport within lipid bilayer

[Term]
id: GO:0032597
name: B cell receptor transport into membrane raft
namespace: biological_process
def: "The directed movement of a B cell receptor into a membrane raft." [GOC:mah]
synonym: "B cell receptor translocation into membrane raft" EXACT []
synonym: "B cell receptor transport into lipid raft" EXACT []
synonym: "BCR translocation into membrane raft" EXACT []
synonym: "BCR transport into membrane raft" EXACT []
is_a: GO:0032595 ! B cell receptor transport within lipid bilayer
is_a: GO:0032596 ! protein transport into membrane raft

[Term]
id: GO:0032598
name: B cell receptor transport into immunological synapse
namespace: biological_process
def: "The directed movement of a B cell receptor into an immunological synapse." [GOC:mah]
synonym: "B cell receptor translocation into immunological synapse" EXACT []
synonym: "BCR translocation into immunological synapse" EXACT []
synonym: "BCR transport into immunological synapse" EXACT []
is_a: GO:0032597 ! B cell receptor transport into membrane raft

[Term]
id: GO:0032599
name: protein transport out of membrane raft
namespace: biological_process
def: "The directed movement of a protein out of a membrane raft." [GOC:mah]
synonym: "protein translocation out of membrane raft" EXACT []
synonym: "protein transport out of lipid raft" EXACT []
synonym: "receptor translocation out of membrane raft" NARROW []
synonym: "receptor transport out of membrane raft" NARROW []
is_a: GO:0032594 ! protein transport within lipid bilayer

[Term]
id: GO:0032600
name: chemokine receptor transport out of membrane raft
namespace: biological_process
def: "The directed movement of a chemokine receptor out of a membrane raft." [GOC:mah]
synonym: "chemokine receptor translocation out of membrane raft" EXACT []
synonym: "chemokine receptor transport out of lipid raft" EXACT []
is_a: GO:0032599 ! protein transport out of membrane raft
is_a: GO:0033606 ! chemokine receptor transport within lipid bilayer

[Term]
id: GO:0032601
name: connective tissue growth factor production
namespace: biological_process
def: "The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "CCN2 production" EXACT []
synonym: "CTGF production" EXACT []
synonym: "Fisp12 production" EXACT []
synonym: "Hcs24 production" EXACT []
synonym: "hypertrophic chondrocyte-specific gene product 24 production" EXACT []
synonym: "IGFBP8 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032602
name: chemokine production
namespace: biological_process
def: "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032603
name: fractalkine production
namespace: biological_process
def: "The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0032604
name: granulocyte macrophage colony-stimulating factor production
namespace: biological_process
def: "The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032605
name: hepatocyte growth factor production
namespace: biological_process
def: "The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032606
name: type I interferon production
namespace: biological_process
def: "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]
synonym: "interferon type I production" EXACT []
synonym: "type I IFN production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032607
name: interferon-alpha production
namespace: biological_process
def: "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0032608
name: interferon-beta production
namespace: biological_process
def: "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
is_a: GO:0032606 ! type I interferon production

[Term]
id: GO:0032609
name: interferon-gamma production
namespace: biological_process
def: "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah]
synonym: "type II interferon production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032610
name: interleukin-1 alpha production
namespace: biological_process
def: "The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-1 alpha production" EXACT []
is_a: GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032611
name: interleukin-1 beta production
namespace: biological_process
def: "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-1 beta production" EXACT []
is_a: GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032612
name: interleukin-1 production
namespace: biological_process
def: "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-1 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032613
name: interleukin-10 production
namespace: biological_process
def: "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-10 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032614
name: interleukin-11 production
namespace: biological_process
def: "The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-11 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032615
name: interleukin-12 production
namespace: biological_process
def: "The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-12 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032616
name: interleukin-13 production
namespace: biological_process
def: "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-13 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032617
name: interleukin-14 production
namespace: biological_process
def: "The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-14 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032618
name: interleukin-15 production
namespace: biological_process
def: "The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-15 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032619
name: interleukin-16 production
namespace: biological_process
def: "The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-16 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032620
name: interleukin-17 production
namespace: biological_process
def: "The appearance of interleukin-17 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-17 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032621
name: interleukin-18 production
namespace: biological_process
def: "The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-18 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032622
name: interleukin-19 production
namespace: biological_process
def: "The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-19 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032623
name: interleukin-2 production
namespace: biological_process
def: "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-2 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032624
name: interleukin-20 production
namespace: biological_process
def: "The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-20 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032625
name: interleukin-21 production
namespace: biological_process
def: "The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-21 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032626
name: interleukin-22 production
namespace: biological_process
def: "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-22 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032627
name: interleukin-23 production
namespace: biological_process
def: "The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-23 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032628
name: interleukin-24 production
namespace: biological_process
def: "The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-24 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032629
name: interleukin-25 production
namespace: biological_process
def: "The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-25 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032630
name: interleukin-26 production
namespace: biological_process
def: "The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-26 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032631
name: interleukin-27 production
namespace: biological_process
def: "The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-27 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032632
name: interleukin-3 production
namespace: biological_process
def: "The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-3 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032633
name: interleukin-4 production
namespace: biological_process
def: "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-4 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032634
name: interleukin-5 production
namespace: biological_process
def: "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-5 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032635
name: interleukin-6 production
namespace: biological_process
def: "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-6 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032636
name: interleukin-7 production
namespace: biological_process
def: "The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-7 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032637
name: interleukin-8 production
namespace: biological_process
def: "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-8 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032638
name: interleukin-9 production
namespace: biological_process
def: "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-9 production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032639
name: TRAIL production
namespace: biological_process
def: "The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032640
name: tumor necrosis factor production
namespace: biological_process
def: "The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "TNF production" EXACT []
synonym: "TNF-alpha production" EXACT []
synonym: "tumor necrosis factor-alpha production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032641
name: lymphotoxin A production
namespace: biological_process
def: "The appearance of lymphotoxin A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "LTA production" EXACT []
synonym: "lymphotoxin-alpha production" EXACT []
synonym: "TNF-beta production" EXACT []
synonym: "tumor necrosis factor-beta production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0032642
name: regulation of chemokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of chemokine production." [GOC:mah]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032602 ! chemokine production

[Term]
id: GO:0032643
name: regulation of connective tissue growth factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah]
synonym: "regulation of CCN2 production" EXACT []
synonym: "regulation of CTGF production" EXACT []
synonym: "regulation of Fisp12 production" EXACT []
synonym: "regulation of Hcs24 production" EXACT []
synonym: "regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT []
synonym: "regulation of IGFBP8 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032601 ! connective tissue growth factor production

[Term]
id: GO:0032644
name: regulation of fractalkine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of fractalkine production." [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0032603 ! fractalkine production

[Term]
id: GO:0032645
name: regulation of granulocyte macrophage colony-stimulating factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production

[Term]
id: GO:0032646
name: regulation of hepatocyte growth factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032605 ! hepatocyte growth factor production

[Term]
id: GO:0032647
name: regulation of interferon-alpha production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interferon-alpha production." [GOC:mah]
is_a: GO:0032479 ! regulation of type I interferon production
relationship: regulates GO:0032607 ! interferon-alpha production

[Term]
id: GO:0032648
name: regulation of interferon-beta production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interferon-beta production." [GOC:mah]
is_a: GO:0032479 ! regulation of type I interferon production
relationship: regulates GO:0032608 ! interferon-beta production

[Term]
id: GO:0032649
name: regulation of interferon-gamma production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah]
synonym: "regulation of type II interferon production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032609 ! interferon-gamma production

[Term]
id: GO:0032650
name: regulation of interleukin-1 alpha production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah]
synonym: "regulation of IL-1 alpha production" EXACT []
is_a: GO:0032652 ! regulation of interleukin-1 production
relationship: regulates GO:0032610 ! interleukin-1 alpha production

[Term]
id: GO:0032651
name: regulation of interleukin-1 beta production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah]
synonym: "regulation of IL-1 beta production" EXACT []
is_a: GO:0032652 ! regulation of interleukin-1 production
relationship: regulates GO:0032611 ! interleukin-1 beta production

[Term]
id: GO:0032652
name: regulation of interleukin-1 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-1 production." [GOC:mah]
synonym: "regulation of IL-1 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032653
name: regulation of interleukin-10 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-10 production." [GOC:mah]
synonym: "regulation of IL-10 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032613 ! interleukin-10 production

[Term]
id: GO:0032654
name: regulation of interleukin-11 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-11 production." [GOC:mah]
synonym: "regulation of IL-11 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032614 ! interleukin-11 production

[Term]
id: GO:0032655
name: regulation of interleukin-12 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-12 production." [GOC:mah]
synonym: "regulation of IL-12 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032615 ! interleukin-12 production

[Term]
id: GO:0032656
name: regulation of interleukin-13 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-13 production." [GOC:mah]
synonym: "regulation of IL-13 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032616 ! interleukin-13 production

[Term]
id: GO:0032657
name: regulation of interleukin-14 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-14 production." [GOC:mah]
synonym: "regulation of IL-14 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032617 ! interleukin-14 production

[Term]
id: GO:0032658
name: regulation of interleukin-15 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-15 production." [GOC:mah]
synonym: "regulation of IL-15 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032618 ! interleukin-15 production

[Term]
id: GO:0032659
name: regulation of interleukin-16 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-16 production." [GOC:mah]
synonym: "regulation of IL-16 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032619 ! interleukin-16 production

[Term]
id: GO:0032660
name: regulation of interleukin-17 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-17 production." [GOC:mah]
synonym: "regulation of IL-17 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032620 ! interleukin-17 production

[Term]
id: GO:0032661
name: regulation of interleukin-18 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-18 production." [GOC:mah]
synonym: "regulation of IL-18 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032621 ! interleukin-18 production

[Term]
id: GO:0032662
name: regulation of interleukin-19 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-19 production." [GOC:mah]
synonym: "regulation of IL-19 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032622 ! interleukin-19 production

[Term]
id: GO:0032663
name: regulation of interleukin-2 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-2 production." [GOC:mah]
synonym: "regulation of IL-2 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032623 ! interleukin-2 production

[Term]
id: GO:0032664
name: regulation of interleukin-20 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-20 production." [GOC:mah]
synonym: "regulation of IL-20 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032624 ! interleukin-20 production

[Term]
id: GO:0032665
name: regulation of interleukin-21 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-21 production." [GOC:mah]
synonym: "regulation of IL-21 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032625 ! interleukin-21 production

[Term]
id: GO:0032666
name: regulation of interleukin-22 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-22 production." [GOC:mah]
synonym: "regulation of IL-22 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032626 ! interleukin-22 production

[Term]
id: GO:0032667
name: regulation of interleukin-23 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-23 production." [GOC:mah]
synonym: "regulation of IL-23 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032627 ! interleukin-23 production

[Term]
id: GO:0032668
name: regulation of interleukin-24 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-24 production." [GOC:mah]
synonym: "regulation of IL-24 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032628 ! interleukin-24 production

[Term]
id: GO:0032669
name: regulation of interleukin-25 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-25 production." [GOC:mah]
synonym: "regulation of IL-25 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032629 ! interleukin-25 production

[Term]
id: GO:0032670
name: regulation of interleukin-26 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-26 production." [GOC:mah]
synonym: "regulation of IL-26 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032630 ! interleukin-26 production

[Term]
id: GO:0032671
name: regulation of interleukin-27 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-27 production." [GOC:mah]
synonym: "regulation of IL-27 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032631 ! interleukin-27 production

[Term]
id: GO:0032672
name: regulation of interleukin-3 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-3 production." [GOC:mah]
synonym: "regulation of IL-3 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032632 ! interleukin-3 production

[Term]
id: GO:0032673
name: regulation of interleukin-4 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-4 production." [GOC:mah]
synonym: "regulation of IL-4 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032633 ! interleukin-4 production

[Term]
id: GO:0032674
name: regulation of interleukin-5 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-5 production." [GOC:mah]
synonym: "regulation of IL-5 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032634 ! interleukin-5 production

[Term]
id: GO:0032675
name: regulation of interleukin-6 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-6 production." [GOC:mah]
synonym: "regulation of IL-6 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032635 ! interleukin-6 production

[Term]
id: GO:0032676
name: regulation of interleukin-7 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-7 production." [GOC:mah]
synonym: "regulation of IL-7 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032636 ! interleukin-7 production

[Term]
id: GO:0032677
name: regulation of interleukin-8 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-8 production." [GOC:mah]
synonym: "regulation of IL-8 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032637 ! interleukin-8 production

[Term]
id: GO:0032678
name: regulation of interleukin-9 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-9 production." [GOC:mah]
synonym: "regulation of IL-9 production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032638 ! interleukin-9 production

[Term]
id: GO:0032679
name: regulation of TRAIL production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of TRAIL production." [GOC:mah]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032639 ! TRAIL production

[Term]
id: GO:0032680
name: regulation of tumor necrosis factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "regulation of TNF production" EXACT []
synonym: "regulation of TNF-alpha production" EXACT []
synonym: "regulation of tumor necrosis factor-alpha production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032640 ! tumor necrosis factor production

[Term]
id: GO:0032681
name: regulation of lymphotoxin A production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of lymphotoxin A production." [GOC:mah]
synonym: "regulation of LTA production" EXACT []
synonym: "regulation of lymphotoxin-alpha production" EXACT []
synonym: "regulation of TNF-beta production" EXACT []
synonym: "regulation of tumor necrosis factor-beta production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0032641 ! lymphotoxin A production

[Term]
id: GO:0032682
name: negative regulation of chemokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production." [GOC:mah]
synonym: "down regulation of chemokine production" EXACT []
synonym: "down-regulation of chemokine production" EXACT []
synonym: "downregulation of chemokine production" EXACT []
synonym: "inhibition of chemokine production" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032642 ! regulation of chemokine production
relationship: negatively_regulates GO:0032602 ! chemokine production

[Term]
id: GO:0032683
name: negative regulation of connective tissue growth factor production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah]
synonym: "down regulation of connective tissue growth factor production" EXACT []
synonym: "down-regulation of connective tissue growth factor production" EXACT []
synonym: "downregulation of connective tissue growth factor production" EXACT []
synonym: "inhibition of connective tissue growth factor production" NARROW []
synonym: "negative regulation of CCN2 production" EXACT []
synonym: "negative regulation of CTGF production" EXACT []
synonym: "negative regulation of Fisp12 production" EXACT []
synonym: "negative regulation of Hcs24 production" EXACT []
synonym: "negative regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT []
synonym: "negative regulation of IGFBP8 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032643 ! regulation of connective tissue growth factor production
relationship: negatively_regulates GO:0032601 ! connective tissue growth factor production

[Term]
id: GO:0032684
name: negative regulation of fractalkine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of fractalkine production." [GOC:mah]
synonym: "down regulation of fractalkine production" EXACT []
synonym: "down-regulation of fractalkine production" EXACT []
synonym: "downregulation of fractalkine production" EXACT []
synonym: "inhibition of fractalkine production" NARROW []
is_a: GO:0032644 ! regulation of fractalkine production
is_a: GO:0032682 ! negative regulation of chemokine production
relationship: negatively_regulates GO:0032603 ! fractalkine production

[Term]
id: GO:0032685
name: negative regulation of granulocyte macrophage colony-stimulating factor production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah]
synonym: "down regulation of granulocyte macrophage colony-stimulating factor production" EXACT []
synonym: "down-regulation of granulocyte macrophage colony-stimulating factor production" EXACT []
synonym: "downregulation of granulocyte macrophage colony-stimulating factor production" EXACT []
synonym: "inhibition of granulocyte macrophage colony-stimulating factor production" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production
relationship: negatively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production

[Term]
id: GO:0032686
name: negative regulation of hepatocyte growth factor production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah]
synonym: "down regulation of hepatocyte growth factor production" EXACT []
synonym: "down-regulation of hepatocyte growth factor production" EXACT []
synonym: "downregulation of hepatocyte growth factor production" EXACT []
synonym: "inhibition of hepatocyte growth factor production" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032646 ! regulation of hepatocyte growth factor production
relationship: negatively_regulates GO:0032605 ! hepatocyte growth factor production

[Term]
id: GO:0032687
name: negative regulation of interferon-alpha production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production." [GOC:mah]
synonym: "down regulation of interferon-alpha production" EXACT []
synonym: "down-regulation of interferon-alpha production" EXACT []
synonym: "downregulation of interferon-alpha production" EXACT []
synonym: "inhibition of interferon-alpha production" NARROW []
is_a: GO:0032480 ! negative regulation of type I interferon production
is_a: GO:0032647 ! regulation of interferon-alpha production
relationship: negatively_regulates GO:0032607 ! interferon-alpha production

[Term]
id: GO:0032688
name: negative regulation of interferon-beta production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production." [GOC:mah]
synonym: "down regulation of interferon-beta production" EXACT []
synonym: "down-regulation of interferon-beta production" EXACT []
synonym: "downregulation of interferon-beta production" EXACT []
synonym: "inhibition of interferon-beta production" NARROW []
is_a: GO:0032480 ! negative regulation of type I interferon production
is_a: GO:0032648 ! regulation of interferon-beta production
relationship: negatively_regulates GO:0032608 ! interferon-beta production

[Term]
id: GO:0032689
name: negative regulation of interferon-gamma production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah]
synonym: "down regulation of interferon-gamma production" EXACT []
synonym: "down-regulation of interferon-gamma production" EXACT []
synonym: "downregulation of interferon-gamma production" EXACT []
synonym: "inhibition of interferon-gamma production" NARROW []
synonym: "negative regulation of type II interferon production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032649 ! regulation of interferon-gamma production
relationship: negatively_regulates GO:0032609 ! interferon-gamma production

[Term]
id: GO:0032690
name: negative regulation of interleukin-1 alpha production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah]
synonym: "down regulation of interleukin-1 alpha production" EXACT []
synonym: "down-regulation of interleukin-1 alpha production" EXACT []
synonym: "downregulation of interleukin-1 alpha production" EXACT []
synonym: "inhibition of interleukin-1 alpha production" NARROW []
synonym: "negative regulation of IL-1 alpha production" EXACT []
is_a: GO:0032650 ! regulation of interleukin-1 alpha production
is_a: GO:0032692 ! negative regulation of interleukin-1 production
relationship: negatively_regulates GO:0032610 ! interleukin-1 alpha production

[Term]
id: GO:0032691
name: negative regulation of interleukin-1 beta production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah]
synonym: "down regulation of interleukin-1 beta production" EXACT []
synonym: "down-regulation of interleukin-1 beta production" EXACT []
synonym: "downregulation of interleukin-1 beta production" EXACT []
synonym: "inhibition of interleukin-1 beta production" NARROW []
synonym: "negative regulation of IL-1 beta production" EXACT []
is_a: GO:0032651 ! regulation of interleukin-1 beta production
is_a: GO:0032692 ! negative regulation of interleukin-1 production
relationship: negatively_regulates GO:0032611 ! interleukin-1 beta production

[Term]
id: GO:0032692
name: negative regulation of interleukin-1 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production." [GOC:mah]
synonym: "down regulation of interleukin-1 production" EXACT []
synonym: "down-regulation of interleukin-1 production" EXACT []
synonym: "downregulation of interleukin-1 production" EXACT []
synonym: "inhibition of interleukin-1 production" NARROW []
synonym: "negative regulation of IL-1 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032652 ! regulation of interleukin-1 production
relationship: negatively_regulates GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032693
name: negative regulation of interleukin-10 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production." [GOC:mah]
synonym: "down regulation of interleukin-10 production" EXACT []
synonym: "down-regulation of interleukin-10 production" EXACT []
synonym: "downregulation of interleukin-10 production" EXACT []
synonym: "inhibition of interleukin-10 production" NARROW []
synonym: "negative regulation of IL-10 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032653 ! regulation of interleukin-10 production
relationship: negatively_regulates GO:0032613 ! interleukin-10 production

[Term]
id: GO:0032694
name: negative regulation of interleukin-11 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production." [GOC:mah]
synonym: "down regulation of interleukin-11 production" EXACT []
synonym: "down-regulation of interleukin-11 production" EXACT []
synonym: "downregulation of interleukin-11 production" EXACT []
synonym: "inhibition of interleukin-11 production" NARROW []
synonym: "negative regulation of IL-11 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032654 ! regulation of interleukin-11 production
relationship: negatively_regulates GO:0032614 ! interleukin-11 production

[Term]
id: GO:0032695
name: negative regulation of interleukin-12 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production." [GOC:mah]
synonym: "down regulation of interleukin-12 production" EXACT []
synonym: "down-regulation of interleukin-12 production" EXACT []
synonym: "downregulation of interleukin-12 production" EXACT []
synonym: "inhibition of interleukin-12 production" NARROW []
synonym: "negative regulation of IL-12 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032655 ! regulation of interleukin-12 production
relationship: negatively_regulates GO:0032615 ! interleukin-12 production

[Term]
id: GO:0032696
name: negative regulation of interleukin-13 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production." [GOC:mah]
synonym: "down regulation of interleukin-13 production" EXACT []
synonym: "down-regulation of interleukin-13 production" EXACT []
synonym: "downregulation of interleukin-13 production" EXACT []
synonym: "inhibition of interleukin-13 production" NARROW []
synonym: "negative regulation of IL-13 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032656 ! regulation of interleukin-13 production
relationship: negatively_regulates GO:0032616 ! interleukin-13 production

[Term]
id: GO:0032697
name: negative regulation of interleukin-14 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-14 production." [GOC:mah]
synonym: "down regulation of interleukin-14 production" EXACT []
synonym: "down-regulation of interleukin-14 production" EXACT []
synonym: "downregulation of interleukin-14 production" EXACT []
synonym: "inhibition of interleukin-14 production" NARROW []
synonym: "negative regulation of IL-14 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032657 ! regulation of interleukin-14 production
relationship: negatively_regulates GO:0032617 ! interleukin-14 production

[Term]
id: GO:0032698
name: negative regulation of interleukin-15 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production." [GOC:mah]
synonym: "down regulation of interleukin-15 production" EXACT []
synonym: "down-regulation of interleukin-15 production" EXACT []
synonym: "downregulation of interleukin-15 production" EXACT []
synonym: "inhibition of interleukin-15 production" NARROW []
synonym: "negative regulation of IL-15 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032658 ! regulation of interleukin-15 production
relationship: negatively_regulates GO:0032618 ! interleukin-15 production

[Term]
id: GO:0032699
name: negative regulation of interleukin-16 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production." [GOC:mah]
synonym: "down regulation of interleukin-16 production" EXACT []
synonym: "down-regulation of interleukin-16 production" EXACT []
synonym: "downregulation of interleukin-16 production" EXACT []
synonym: "inhibition of interleukin-16 production" NARROW []
synonym: "negative regulation of IL-16 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032659 ! regulation of interleukin-16 production
relationship: negatively_regulates GO:0032619 ! interleukin-16 production

[Term]
id: GO:0032700
name: negative regulation of interleukin-17 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-17 production." [GOC:mah]
synonym: "down regulation of interleukin-17 production" EXACT []
synonym: "down-regulation of interleukin-17 production" EXACT []
synonym: "downregulation of interleukin-17 production" EXACT []
synonym: "inhibition of interleukin-17 production" NARROW []
synonym: "negative regulation of IL-17 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032660 ! regulation of interleukin-17 production
relationship: negatively_regulates GO:0032620 ! interleukin-17 production

[Term]
id: GO:0032701
name: negative regulation of interleukin-18 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production." [GOC:mah]
synonym: "down regulation of interleukin-18 production" EXACT []
synonym: "down-regulation of interleukin-18 production" EXACT []
synonym: "downregulation of interleukin-18 production" EXACT []
synonym: "inhibition of interleukin-18 production" NARROW []
synonym: "negative regulation of IL-18 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032661 ! regulation of interleukin-18 production
relationship: negatively_regulates GO:0032621 ! interleukin-18 production

[Term]
id: GO:0032702
name: negative regulation of interleukin-19 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production." [GOC:mah]
synonym: "down regulation of interleukin-19 production" EXACT []
synonym: "down-regulation of interleukin-19 production" EXACT []
synonym: "downregulation of interleukin-19 production" EXACT []
synonym: "inhibition of interleukin-19 production" NARROW []
synonym: "negative regulation of IL-19 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032662 ! regulation of interleukin-19 production
relationship: negatively_regulates GO:0032622 ! interleukin-19 production

[Term]
id: GO:0032703
name: negative regulation of interleukin-2 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production." [GOC:mah]
synonym: "down regulation of interleukin-2 production" EXACT []
synonym: "down-regulation of interleukin-2 production" EXACT []
synonym: "downregulation of interleukin-2 production" EXACT []
synonym: "inhibition of interleukin-2 production" NARROW []
synonym: "negative regulation of IL-2 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032663 ! regulation of interleukin-2 production
relationship: negatively_regulates GO:0032623 ! interleukin-2 production

[Term]
id: GO:0032704
name: negative regulation of interleukin-20 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production." [GOC:mah]
synonym: "down regulation of interleukin-20 production" EXACT []
synonym: "down-regulation of interleukin-20 production" EXACT []
synonym: "downregulation of interleukin-20 production" EXACT []
synonym: "inhibition of interleukin-20 production" NARROW []
synonym: "negative regulation of IL-20 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032664 ! regulation of interleukin-20 production
relationship: negatively_regulates GO:0032624 ! interleukin-20 production

[Term]
id: GO:0032705
name: negative regulation of interleukin-21 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-21 production." [GOC:mah]
synonym: "down regulation of interleukin-21 production" EXACT []
synonym: "down-regulation of interleukin-21 production" EXACT []
synonym: "downregulation of interleukin-21 production" EXACT []
synonym: "inhibition of interleukin-21 production" NARROW []
synonym: "negative regulation of IL-21 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032665 ! regulation of interleukin-21 production
relationship: negatively_regulates GO:0032625 ! interleukin-21 production

[Term]
id: GO:0032706
name: negative regulation of interleukin-22 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production." [GOC:mah]
synonym: "down regulation of interleukin-22 production" EXACT []
synonym: "down-regulation of interleukin-22 production" EXACT []
synonym: "downregulation of interleukin-22 production" EXACT []
synonym: "inhibition of interleukin-22 production" NARROW []
synonym: "negative regulation of IL-22 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032666 ! regulation of interleukin-22 production
relationship: negatively_regulates GO:0032626 ! interleukin-22 production

[Term]
id: GO:0032707
name: negative regulation of interleukin-23 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production." [GOC:mah]
synonym: "down regulation of interleukin-23 production" EXACT []
synonym: "down-regulation of interleukin-23 production" EXACT []
synonym: "downregulation of interleukin-23 production" EXACT []
synonym: "inhibition of interleukin-23 production" NARROW []
synonym: "negative regulation of IL-23 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032667 ! regulation of interleukin-23 production
relationship: negatively_regulates GO:0032627 ! interleukin-23 production

[Term]
id: GO:0032708
name: negative regulation of interleukin-24 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production." [GOC:mah]
synonym: "down regulation of interleukin-24 production" EXACT []
synonym: "down-regulation of interleukin-24 production" EXACT []
synonym: "downregulation of interleukin-24 production" EXACT []
synonym: "inhibition of interleukin-24 production" NARROW []
synonym: "negative regulation of IL-24 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032668 ! regulation of interleukin-24 production
relationship: negatively_regulates GO:0032628 ! interleukin-24 production

[Term]
id: GO:0032709
name: negative regulation of interleukin-25 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production." [GOC:mah]
synonym: "down regulation of interleukin-25 production" EXACT []
synonym: "down-regulation of interleukin-25 production" EXACT []
synonym: "downregulation of interleukin-25 production" EXACT []
synonym: "inhibition of interleukin-25 production" NARROW []
synonym: "negative regulation of IL-25 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032669 ! regulation of interleukin-25 production
relationship: negatively_regulates GO:0032629 ! interleukin-25 production

[Term]
id: GO:0032710
name: negative regulation of interleukin-26 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production." [GOC:mah]
synonym: "down regulation of interleukin-26 production" EXACT []
synonym: "down-regulation of interleukin-26 production" EXACT []
synonym: "downregulation of interleukin-26 production" EXACT []
synonym: "inhibition of interleukin-26 production" NARROW []
synonym: "negative regulation of IL-26 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032670 ! regulation of interleukin-26 production
relationship: negatively_regulates GO:0032630 ! interleukin-26 production

[Term]
id: GO:0032711
name: negative regulation of interleukin-27 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-27 production." [GOC:mah]
synonym: "down regulation of interleukin-27 production" EXACT []
synonym: "down-regulation of interleukin-27 production" EXACT []
synonym: "downregulation of interleukin-27 production" EXACT []
synonym: "inhibition of interleukin-27 production" NARROW []
synonym: "negative regulation of IL-27 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032671 ! regulation of interleukin-27 production
relationship: negatively_regulates GO:0032631 ! interleukin-27 production

[Term]
id: GO:0032712
name: negative regulation of interleukin-3 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production." [GOC:mah]
synonym: "down regulation of interleukin-3 production" EXACT []
synonym: "down-regulation of interleukin-3 production" EXACT []
synonym: "downregulation of interleukin-3 production" EXACT []
synonym: "inhibition of interleukin-3 production" NARROW []
synonym: "negative regulation of IL-3 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032672 ! regulation of interleukin-3 production
relationship: negatively_regulates GO:0032632 ! interleukin-3 production

[Term]
id: GO:0032713
name: negative regulation of interleukin-4 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production." [GOC:mah]
synonym: "down regulation of interleukin-4 production" EXACT []
synonym: "down-regulation of interleukin-4 production" EXACT []
synonym: "downregulation of interleukin-4 production" EXACT []
synonym: "inhibition of interleukin-4 production" NARROW []
synonym: "negative regulation of IL-4 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032673 ! regulation of interleukin-4 production
relationship: negatively_regulates GO:0032633 ! interleukin-4 production

[Term]
id: GO:0032714
name: negative regulation of interleukin-5 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production." [GOC:mah]
synonym: "down regulation of interleukin-5 production" EXACT []
synonym: "down-regulation of interleukin-5 production" EXACT []
synonym: "downregulation of interleukin-5 production" EXACT []
synonym: "inhibition of interleukin-5 production" NARROW []
synonym: "negative regulation of IL-5 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032674 ! regulation of interleukin-5 production
relationship: negatively_regulates GO:0032634 ! interleukin-5 production

[Term]
id: GO:0032715
name: negative regulation of interleukin-6 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production." [GOC:mah]
synonym: "down regulation of interleukin-6 production" EXACT []
synonym: "down-regulation of interleukin-6 production" EXACT []
synonym: "downregulation of interleukin-6 production" EXACT []
synonym: "inhibition of interleukin-6 production" NARROW []
synonym: "negative regulation of IL-6 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032675 ! regulation of interleukin-6 production
relationship: negatively_regulates GO:0032635 ! interleukin-6 production

[Term]
id: GO:0032716
name: negative regulation of interleukin-7 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production." [GOC:mah]
synonym: "down regulation of interleukin-7 production" EXACT []
synonym: "down-regulation of interleukin-7 production" EXACT []
synonym: "downregulation of interleukin-7 production" EXACT []
synonym: "inhibition of interleukin-7 production" NARROW []
synonym: "negative regulation of IL-7 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032676 ! regulation of interleukin-7 production
relationship: negatively_regulates GO:0032636 ! interleukin-7 production

[Term]
id: GO:0032717
name: negative regulation of interleukin-8 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production." [GOC:mah]
synonym: "down regulation of interleukin-8 production" EXACT []
synonym: "down-regulation of interleukin-8 production" EXACT []
synonym: "downregulation of interleukin-8 production" EXACT []
synonym: "inhibition of interleukin-8 production" NARROW []
synonym: "negative regulation of IL-8 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032677 ! regulation of interleukin-8 production
relationship: negatively_regulates GO:0032637 ! interleukin-8 production

[Term]
id: GO:0032718
name: negative regulation of interleukin-9 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production." [GOC:mah]
synonym: "down regulation of interleukin-9 production" EXACT []
synonym: "down-regulation of interleukin-9 production" EXACT []
synonym: "downregulation of interleukin-9 production" EXACT []
synonym: "inhibition of interleukin-9 production" NARROW []
synonym: "negative regulation of IL-9 production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032678 ! regulation of interleukin-9 production
relationship: negatively_regulates GO:0032638 ! interleukin-9 production

[Term]
id: GO:0032719
name: negative regulation of TRAIL production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of TRAIL production." [GOC:mah]
synonym: "down regulation of TRAIL production" EXACT []
synonym: "down-regulation of TRAIL production" EXACT []
synonym: "downregulation of TRAIL production" EXACT []
synonym: "inhibition of TRAIL production" NARROW []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032679 ! regulation of TRAIL production
relationship: negatively_regulates GO:0032639 ! TRAIL production

[Term]
id: GO:0032720
name: negative regulation of tumor necrosis factor production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "down regulation of tumor necrosis factor production" EXACT []
synonym: "down-regulation of tumor necrosis factor production" EXACT []
synonym: "downregulation of tumor necrosis factor production" EXACT []
synonym: "inhibition of tumor necrosis factor production" NARROW []
synonym: "negative regulation TNF production" EXACT []
synonym: "negative regulation TNF-alpha production" EXACT []
synonym: "negative regulation tumor necrosis factor-alpha production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032680 ! regulation of tumor necrosis factor production
relationship: negatively_regulates GO:0032640 ! tumor necrosis factor production

[Term]
id: GO:0032721
name: negative regulation of lymphotoxin A production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphotoxin A production." [GOC:mah]
synonym: "down regulation of lymphotoxin A production" EXACT []
synonym: "down-regulation of lymphotoxin A production" EXACT []
synonym: "downregulation of lymphotoxin A production" EXACT []
synonym: "inhibition of lymphotoxin A production" NARROW []
synonym: "negative regulation of LTA production" EXACT []
synonym: "negative regulation of lymphotoxin-alpha production" EXACT []
synonym: "negative regulation of TNF-beta production" EXACT []
synonym: "negative regulation of tumor necrosis factor-beta production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0032681 ! regulation of lymphotoxin A production
relationship: negatively_regulates GO:0032641 ! lymphotoxin A production

[Term]
id: GO:0032722
name: positive regulation of chemokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of chemokine production." [GOC:mah]
synonym: "activation of chemokine production" NARROW []
synonym: "stimulation of chemokine production" NARROW []
synonym: "up regulation of chemokine production" EXACT []
synonym: "up-regulation of chemokine production" EXACT []
synonym: "upregulation of chemokine production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032642 ! regulation of chemokine production
relationship: positively_regulates GO:0032602 ! chemokine production

[Term]
id: GO:0032723
name: positive regulation of connective tissue growth factor production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah]
synonym: "activation of connective tissue growth factor production" NARROW []
synonym: "positive regulation of CCN2 production" EXACT []
synonym: "positive regulation of CTGF production" EXACT []
synonym: "positive regulation of Fisp12 production" EXACT []
synonym: "positive regulation of Hcs24 production" EXACT []
synonym: "positive regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT []
synonym: "positive regulation of IGFBP8 production" EXACT []
synonym: "stimulation of connective tissue growth factor production" NARROW []
synonym: "up regulation of connective tissue growth factor production" EXACT []
synonym: "up-regulation of connective tissue growth factor production" EXACT []
synonym: "upregulation of connective tissue growth factor production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032643 ! regulation of connective tissue growth factor production
relationship: positively_regulates GO:0032601 ! connective tissue growth factor production

[Term]
id: GO:0032724
name: positive regulation of fractalkine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of fractalkine production." [GOC:mah]
synonym: "activation of fractalkine production" NARROW []
synonym: "stimulation of fractalkine production" NARROW []
synonym: "up regulation of fractalkine production" EXACT []
synonym: "up-regulation of fractalkine production" EXACT []
synonym: "upregulation of fractalkine production" EXACT []
is_a: GO:0032644 ! regulation of fractalkine production
is_a: GO:0032722 ! positive regulation of chemokine production
relationship: positively_regulates GO:0032603 ! fractalkine production

[Term]
id: GO:0032725
name: positive regulation of granulocyte macrophage colony-stimulating factor production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah]
synonym: "activation of granulocyte macrophage colony-stimulating factor production" NARROW []
synonym: "stimulation of granulocyte macrophage colony-stimulating factor production" NARROW []
synonym: "up regulation of granulocyte macrophage colony-stimulating factor production" EXACT []
synonym: "up-regulation of granulocyte macrophage colony-stimulating factor production" EXACT []
synonym: "upregulation of granulocyte macrophage colony-stimulating factor production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production
relationship: positively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production

[Term]
id: GO:0032726
name: positive regulation of hepatocyte growth factor production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah]
synonym: "activation of hepatocyte growth factor production" NARROW []
synonym: "stimulation of hepatocyte growth factor production" NARROW []
synonym: "up regulation of hepatocyte growth factor production" EXACT []
synonym: "up-regulation of hepatocyte growth factor production" EXACT []
synonym: "upregulation of hepatocyte growth factor production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032646 ! regulation of hepatocyte growth factor production
relationship: positively_regulates GO:0032605 ! hepatocyte growth factor production

[Term]
id: GO:0032727
name: positive regulation of interferon-alpha production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interferon-alpha production." [GOC:mah]
synonym: "activation of interferon-alpha production" NARROW []
synonym: "stimulation of interferon-alpha production" NARROW []
synonym: "up regulation of interferon-alpha production" EXACT []
synonym: "up-regulation of interferon-alpha production" EXACT []
synonym: "upregulation of interferon-alpha production" EXACT []
is_a: GO:0032481 ! positive regulation of type I interferon production
is_a: GO:0032647 ! regulation of interferon-alpha production
relationship: positively_regulates GO:0032607 ! interferon-alpha production

[Term]
id: GO:0032728
name: positive regulation of interferon-beta production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta production." [GOC:mah]
synonym: "activation of interferon-beta production" NARROW []
synonym: "stimulation of interferon-beta production" NARROW []
synonym: "up regulation of interferon-beta production" EXACT []
synonym: "up-regulation of interferon-beta production" EXACT []
synonym: "upregulation of interferon-beta production" EXACT []
is_a: GO:0032481 ! positive regulation of type I interferon production
is_a: GO:0032648 ! regulation of interferon-beta production
relationship: positively_regulates GO:0032608 ! interferon-beta production

[Term]
id: GO:0032729
name: positive regulation of interferon-gamma production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah]
synonym: "activation of interferon-gamma production" NARROW []
synonym: "positive regulation of type II interferon production" EXACT []
synonym: "stimulation of interferon-gamma production" NARROW []
synonym: "up regulation of interferon-gamma production" EXACT []
synonym: "up-regulation of interferon-gamma production" EXACT []
synonym: "upregulation of interferon-gamma production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032649 ! regulation of interferon-gamma production
relationship: positively_regulates GO:0032609 ! interferon-gamma production

[Term]
id: GO:0032730
name: positive regulation of interleukin-1 alpha production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah]
synonym: "activation of interleukin-1 alpha production" NARROW []
synonym: "positive regulation of IL-1 alpha production" EXACT []
synonym: "stimulation of interleukin-1 alpha production" NARROW []
synonym: "up regulation of interleukin-1 alpha production" EXACT []
synonym: "up-regulation of interleukin-1 alpha production" EXACT []
synonym: "upregulation of interleukin-1 alpha production" EXACT []
is_a: GO:0032650 ! regulation of interleukin-1 alpha production
is_a: GO:0032732 ! positive regulation of interleukin-1 production
relationship: positively_regulates GO:0032610 ! interleukin-1 alpha production

[Term]
id: GO:0032731
name: positive regulation of interleukin-1 beta production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah]
synonym: "activation of interleukin-1 beta production" NARROW []
synonym: "positive regulation of IL-1 beta production" EXACT []
synonym: "stimulation of interleukin-1 beta production" NARROW []
synonym: "up regulation of interleukin-1 beta production" EXACT []
synonym: "up-regulation of interleukin-1 beta production" EXACT []
synonym: "upregulation of interleukin-1 beta production" EXACT []
is_a: GO:0032651 ! regulation of interleukin-1 beta production
is_a: GO:0032732 ! positive regulation of interleukin-1 production
relationship: positively_regulates GO:0032611 ! interleukin-1 beta production

[Term]
id: GO:0032732
name: positive regulation of interleukin-1 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 production." [GOC:mah]
synonym: "activation of interleukin-1 production" NARROW []
synonym: "positive regulation of IL-1 production" EXACT []
synonym: "stimulation of interleukin-1 production" NARROW []
synonym: "up regulation of interleukin-1 production" EXACT []
synonym: "up-regulation of interleukin-1 production" EXACT []
synonym: "upregulation of interleukin-1 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032652 ! regulation of interleukin-1 production
relationship: positively_regulates GO:0032612 ! interleukin-1 production

[Term]
id: GO:0032733
name: positive regulation of interleukin-10 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-10 production." [GOC:mah]
synonym: "activation of interleukin-10 production" NARROW []
synonym: "positive regulation of IL-10 production" EXACT []
synonym: "stimulation of interleukin-10 production" NARROW []
synonym: "up regulation of interleukin-10 production" EXACT []
synonym: "up-regulation of interleukin-10 production" EXACT []
synonym: "upregulation of interleukin-10 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032653 ! regulation of interleukin-10 production
relationship: positively_regulates GO:0032613 ! interleukin-10 production

[Term]
id: GO:0032734
name: positive regulation of interleukin-11 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-11 production." [GOC:mah]
synonym: "activation of interleukin-11 production" NARROW []
synonym: "positive regulation of IL-11 production" EXACT []
synonym: "stimulation of interleukin-11 production" NARROW []
synonym: "up regulation of interleukin-11 production" EXACT []
synonym: "up-regulation of interleukin-11 production" EXACT []
synonym: "upregulation of interleukin-11 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032654 ! regulation of interleukin-11 production
relationship: positively_regulates GO:0032614 ! interleukin-11 production

[Term]
id: GO:0032735
name: positive regulation of interleukin-12 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-12 production." [GOC:mah]
synonym: "activation of interleukin-12 production" NARROW []
synonym: "positive regulation of IL-12 production" EXACT []
synonym: "stimulation of interleukin-12 production" NARROW []
synonym: "up regulation of interleukin-12 production" EXACT []
synonym: "up-regulation of interleukin-12 production" EXACT []
synonym: "upregulation of interleukin-12 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032655 ! regulation of interleukin-12 production
relationship: positively_regulates GO:0032615 ! interleukin-12 production

[Term]
id: GO:0032736
name: positive regulation of interleukin-13 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-13 production." [GOC:mah]
synonym: "activation of interleukin-13 production" NARROW []
synonym: "positive regulation of IL-13 production" EXACT []
synonym: "stimulation of interleukin-13 production" NARROW []
synonym: "up regulation of interleukin-13 production" EXACT []
synonym: "up-regulation of interleukin-13 production" EXACT []
synonym: "upregulation of interleukin-13 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032656 ! regulation of interleukin-13 production
relationship: positively_regulates GO:0032616 ! interleukin-13 production

[Term]
id: GO:0032737
name: positive regulation of interleukin-14 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-14 production." [GOC:mah]
synonym: "activation of interleukin-14 production" NARROW []
synonym: "positive regulation of IL-14 production" EXACT []
synonym: "stimulation of interleukin-14 production" NARROW []
synonym: "up regulation of interleukin-14 production" EXACT []
synonym: "up-regulation of interleukin-14 production" EXACT []
synonym: "upregulation of interleukin-14 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032657 ! regulation of interleukin-14 production
relationship: positively_regulates GO:0032617 ! interleukin-14 production

[Term]
id: GO:0032738
name: positive regulation of interleukin-15 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-15 production." [GOC:mah]
synonym: "activation of interleukin-15 production" NARROW []
synonym: "positive regulation of IL-15 production" EXACT []
synonym: "stimulation of interleukin-15 production" NARROW []
synonym: "up regulation of interleukin-15 production" EXACT []
synonym: "up-regulation of interleukin-15 production" EXACT []
synonym: "upregulation of interleukin-15 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032658 ! regulation of interleukin-15 production
relationship: positively_regulates GO:0032618 ! interleukin-15 production

[Term]
id: GO:0032739
name: positive regulation of interleukin-16 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-16 production." [GOC:mah]
synonym: "activation of interleukin-16 production" NARROW []
synonym: "positive regulation of IL-16 production" EXACT []
synonym: "stimulation of interleukin-16 production" NARROW []
synonym: "up regulation of interleukin-16 production" EXACT []
synonym: "up-regulation of interleukin-16 production" EXACT []
synonym: "upregulation of interleukin-16 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032659 ! regulation of interleukin-16 production
relationship: positively_regulates GO:0032619 ! interleukin-16 production

[Term]
id: GO:0032740
name: positive regulation of interleukin-17 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-17 production." [GOC:mah]
synonym: "activation of interleukin-17 production" NARROW []
synonym: "positive regulation of IL-17 production" EXACT []
synonym: "stimulation of interleukin-17 production" NARROW []
synonym: "up regulation of interleukin-17 production" EXACT []
synonym: "up-regulation of interleukin-17 production" EXACT []
synonym: "upregulation of interleukin-17 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032660 ! regulation of interleukin-17 production
relationship: positively_regulates GO:0032620 ! interleukin-17 production

[Term]
id: GO:0032741
name: positive regulation of interleukin-18 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-18 production." [GOC:mah]
synonym: "activation of interleukin-18 production" NARROW []
synonym: "positive regulation of IL-18 production" EXACT []
synonym: "stimulation of interleukin-18 production" NARROW []
synonym: "up regulation of interleukin-18 production" EXACT []
synonym: "up-regulation of interleukin-18 production" EXACT []
synonym: "upregulation of interleukin-18 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032661 ! regulation of interleukin-18 production
relationship: positively_regulates GO:0032621 ! interleukin-18 production

[Term]
id: GO:0032742
name: positive regulation of interleukin-19 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-19 production." [GOC:mah]
synonym: "activation of interleukin-19 production" NARROW []
synonym: "positive regulation of IL-19 production" EXACT []
synonym: "stimulation of interleukin-19 production" NARROW []
synonym: "up regulation of interleukin-19 production" EXACT []
synonym: "up-regulation of interleukin-19 production" EXACT []
synonym: "upregulation of interleukin-19 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032662 ! regulation of interleukin-19 production
relationship: positively_regulates GO:0032622 ! interleukin-19 production

[Term]
id: GO:0032743
name: positive regulation of interleukin-2 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-2 production." [GOC:mah]
synonym: "activation of interleukin-2 production" NARROW []
synonym: "positive regulation of IL-2 production" EXACT []
synonym: "stimulation of interleukin-2 production" NARROW []
synonym: "up regulation of interleukin-2 production" EXACT []
synonym: "up-regulation of interleukin-2 production" EXACT []
synonym: "upregulation of interleukin-2 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032663 ! regulation of interleukin-2 production
relationship: positively_regulates GO:0032623 ! interleukin-2 production

[Term]
id: GO:0032744
name: positive regulation of interleukin-20 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-20 production." [GOC:mah]
synonym: "activation of interleukin-20 production" NARROW []
synonym: "positive regulation of IL-20 production" EXACT []
synonym: "stimulation of interleukin-20 production" NARROW []
synonym: "up regulation of interleukin-20 production" EXACT []
synonym: "up-regulation of interleukin-20 production" EXACT []
synonym: "upregulation of interleukin-20 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032664 ! regulation of interleukin-20 production
relationship: positively_regulates GO:0032624 ! interleukin-20 production

[Term]
id: GO:0032745
name: positive regulation of interleukin-21 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-21 production." [GOC:mah]
synonym: "activation of interleukin-21 production" NARROW []
synonym: "positive regulation of IL-21 production" EXACT []
synonym: "stimulation of interleukin-21 production" NARROW []
synonym: "up regulation of interleukin-21 production" EXACT []
synonym: "up-regulation of interleukin-21 production" EXACT []
synonym: "upregulation of interleukin-21 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032665 ! regulation of interleukin-21 production
relationship: positively_regulates GO:0032625 ! interleukin-21 production

[Term]
id: GO:0032746
name: positive regulation of interleukin-22 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-22 production." [GOC:mah]
synonym: "activation of interleukin-22 production" NARROW []
synonym: "positive regulation of IL-22 production" EXACT []
synonym: "stimulation of interleukin-22 production" NARROW []
synonym: "up regulation of interleukin-22 production" EXACT []
synonym: "up-regulation of interleukin-22 production" EXACT []
synonym: "upregulation of interleukin-22 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032666 ! regulation of interleukin-22 production
relationship: positively_regulates GO:0032626 ! interleukin-22 production

[Term]
id: GO:0032747
name: positive regulation of interleukin-23 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-23 production." [GOC:mah]
synonym: "activation of interleukin-23 production" NARROW []
synonym: "positive regulation of IL-23 production" EXACT []
synonym: "stimulation of interleukin-23 production" NARROW []
synonym: "up regulation of interleukin-23 production" EXACT []
synonym: "up-regulation of interleukin-23 production" EXACT []
synonym: "upregulation of interleukin-23 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032667 ! regulation of interleukin-23 production
relationship: positively_regulates GO:0032627 ! interleukin-23 production

[Term]
id: GO:0032748
name: positive regulation of interleukin-24 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-24 production." [GOC:mah]
synonym: "activation of interleukin-24 production" NARROW []
synonym: "positive regulation of IL-24 production" EXACT []
synonym: "stimulation of interleukin-24 production" NARROW []
synonym: "up regulation of interleukin-24 production" EXACT []
synonym: "up-regulation of interleukin-24 production" EXACT []
synonym: "upregulation of interleukin-24 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032668 ! regulation of interleukin-24 production
relationship: positively_regulates GO:0032628 ! interleukin-24 production

[Term]
id: GO:0032749
name: positive regulation of interleukin-25 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-25 production." [GOC:mah]
synonym: "activation of interleukin-25 production" NARROW []
synonym: "positive regulation of IL-25 production" EXACT []
synonym: "stimulation of interleukin-25 production" NARROW []
synonym: "up regulation of interleukin-25 production" EXACT []
synonym: "up-regulation of interleukin-25 production" EXACT []
synonym: "upregulation of interleukin-25 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032669 ! regulation of interleukin-25 production
relationship: positively_regulates GO:0032629 ! interleukin-25 production

[Term]
id: GO:0032750
name: positive regulation of interleukin-26 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-26 production." [GOC:mah]
synonym: "activation of interleukin-26 production" NARROW []
synonym: "positive regulation of IL-26 production" EXACT []
synonym: "stimulation of interleukin-26 production" NARROW []
synonym: "up regulation of interleukin-26 production" EXACT []
synonym: "up-regulation of interleukin-26 production" EXACT []
synonym: "upregulation of interleukin-26 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032670 ! regulation of interleukin-26 production
relationship: positively_regulates GO:0032630 ! interleukin-26 production

[Term]
id: GO:0032751
name: positive regulation of interleukin-27 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-27 production." [GOC:mah]
synonym: "activation of interleukin-27 production" NARROW []
synonym: "positive regulation of IL-27 production" EXACT []
synonym: "stimulation of interleukin-27 production" NARROW []
synonym: "up regulation of interleukin-27 production" EXACT []
synonym: "up-regulation of interleukin-27 production" EXACT []
synonym: "upregulation of interleukin-27 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032671 ! regulation of interleukin-27 production
relationship: positively_regulates GO:0032631 ! interleukin-27 production

[Term]
id: GO:0032752
name: positive regulation of interleukin-3 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-3 production." [GOC:mah]
synonym: "activation of interleukin-3 production" NARROW []
synonym: "positive regulation of IL-3 production" EXACT []
synonym: "stimulation of interleukin-3 production" NARROW []
synonym: "up regulation of interleukin-3 production" EXACT []
synonym: "up-regulation of interleukin-3 production" EXACT []
synonym: "upregulation of interleukin-3 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032672 ! regulation of interleukin-3 production
relationship: positively_regulates GO:0032632 ! interleukin-3 production

[Term]
id: GO:0032753
name: positive regulation of interleukin-4 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-4 production." [GOC:mah]
synonym: "activation of interleukin-4 production" NARROW []
synonym: "positive regulation of IL-4 production" EXACT []
synonym: "stimulation of interleukin-4 production" NARROW []
synonym: "up regulation of interleukin-4 production" EXACT []
synonym: "up-regulation of interleukin-4 production" EXACT []
synonym: "upregulation of interleukin-4 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032673 ! regulation of interleukin-4 production
relationship: positively_regulates GO:0032633 ! interleukin-4 production

[Term]
id: GO:0032754
name: positive regulation of interleukin-5 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-5 production." [GOC:mah]
synonym: "activation of interleukin-5 production" NARROW []
synonym: "positive regulation of IL-5 production" EXACT []
synonym: "stimulation of interleukin-5 production" NARROW []
synonym: "up regulation of interleukin-5 production" EXACT []
synonym: "up-regulation of interleukin-5 production" EXACT []
synonym: "upregulation of interleukin-5 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032674 ! regulation of interleukin-5 production
relationship: positively_regulates GO:0032634 ! interleukin-5 production

[Term]
id: GO:0032755
name: positive regulation of interleukin-6 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-6 production." [GOC:mah]
synonym: "activation of interleukin-6 production" NARROW []
synonym: "positive regulation of IL-6 production" EXACT []
synonym: "stimulation of interleukin-6 production" NARROW []
synonym: "up regulation of interleukin-6 production" EXACT []
synonym: "up-regulation of interleukin-6 production" EXACT []
synonym: "upregulation of interleukin-6 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032675 ! regulation of interleukin-6 production
relationship: positively_regulates GO:0032635 ! interleukin-6 production

[Term]
id: GO:0032756
name: positive regulation of interleukin-7 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-7 production." [GOC:mah]
synonym: "activation of interleukin-7 production" NARROW []
synonym: "positive regulation of IL-7 production" EXACT []
synonym: "stimulation of interleukin-7 production" NARROW []
synonym: "up regulation of interleukin-7 production" EXACT []
synonym: "up-regulation of interleukin-7 production" EXACT []
synonym: "upregulation of interleukin-7 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032676 ! regulation of interleukin-7 production
relationship: positively_regulates GO:0032636 ! interleukin-7 production

[Term]
id: GO:0032757
name: positive regulation of interleukin-8 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-8 production." [GOC:mah]
synonym: "activation of interleukin-8 production" NARROW []
synonym: "positive regulation of IL-8 production" EXACT []
synonym: "stimulation of interleukin-8 production" NARROW []
synonym: "up regulation of interleukin-8 production" EXACT []
synonym: "up-regulation of interleukin-8 production" EXACT []
synonym: "upregulation of interleukin-8 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032677 ! regulation of interleukin-8 production
relationship: positively_regulates GO:0032637 ! interleukin-8 production

[Term]
id: GO:0032758
name: positive regulation of interleukin-9 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-9 production." [GOC:mah]
synonym: "activation of interleukin-9 production" NARROW []
synonym: "positive regulation of IL-9 production" EXACT []
synonym: "stimulation of interleukin-9 production" NARROW []
synonym: "up regulation of interleukin-9 production" EXACT []
synonym: "up-regulation of interleukin-9 production" EXACT []
synonym: "upregulation of interleukin-9 production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032678 ! regulation of interleukin-9 production
relationship: positively_regulates GO:0032638 ! interleukin-9 production

[Term]
id: GO:0032759
name: positive regulation of TRAIL production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of TRAIL production." [GOC:mah]
synonym: "activation of TRAIL production" NARROW []
synonym: "stimulation of TRAIL production" NARROW []
synonym: "up regulation of TRAIL production" EXACT []
synonym: "up-regulation of TRAIL production" EXACT []
synonym: "upregulation of TRAIL production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032679 ! regulation of TRAIL production
relationship: positively_regulates GO:0032639 ! TRAIL production

[Term]
id: GO:0032760
name: positive regulation of tumor necrosis factor production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "activation of tumor necrosis factor production" NARROW []
synonym: "positive regulation of TNF production" EXACT []
synonym: "positive regulation of TNF-alpha production" EXACT []
synonym: "positive regulation of tumor necrosis factor-alpha production" EXACT []
synonym: "stimulation of tumor necrosis factor production" NARROW []
synonym: "up regulation of tumor necrosis factor production" EXACT []
synonym: "up-regulation of tumor necrosis factor production" EXACT []
synonym: "upregulation of tumor necrosis factor production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032680 ! regulation of tumor necrosis factor production
relationship: positively_regulates GO:0032640 ! tumor necrosis factor production

[Term]
id: GO:0032761
name: positive regulation of lymphotoxin A production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of lymphotoxin A production." [GOC:mah]
synonym: "activation of lymphotoxin A production" NARROW []
synonym: "positive regulation of LTA production" EXACT []
synonym: "positive regulation of lymphotoxin-alpha production" EXACT []
synonym: "positive regulation of TNF-beta production" EXACT []
synonym: "positive regulation of tumor necrosis factor-beta production" EXACT []
synonym: "stimulation of lymphotoxin A production" NARROW []
synonym: "up regulation of lymphotoxin A production" EXACT []
synonym: "up-regulation of lymphotoxin A production" EXACT []
synonym: "upregulation of lymphotoxin A production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0032681 ! regulation of lymphotoxin A production
relationship: positively_regulates GO:0032641 ! lymphotoxin A production

[Term]
id: GO:0032762
name: mast cell cytokine production
namespace: biological_process
def: "Any process that contributes to cytokine production by a mast cell." [GOC:mah]
is_a: GO:0002367 ! cytokine production during immune response

[Term]
id: GO:0032763
name: regulation of mast cell cytokine production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell cytokine production." [GOC:mah]
is_a: GO:0002718 ! regulation of cytokine production during immune response
relationship: regulates GO:0032762 ! mast cell cytokine production

[Term]
id: GO:0032764
name: negative regulation of mast cell cytokine production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production." [GOC:mah]
synonym: "down regulation of mast cell cytokine production" EXACT []
synonym: "down-regulation of mast cell cytokine production" EXACT []
synonym: "downregulation of mast cell cytokine production" EXACT []
synonym: "inhibition of mast cell cytokine production" NARROW []
is_a: GO:0002719 ! negative regulation of cytokine production during immune response
is_a: GO:0032763 ! regulation of mast cell cytokine production
relationship: negatively_regulates GO:0032762 ! mast cell cytokine production

[Term]
id: GO:0032765
name: positive regulation of mast cell cytokine production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production." [GOC:mah]
synonym: "activation of mast cell cytokine production" NARROW []
synonym: "stimulation of mast cell cytokine production" NARROW []
synonym: "up regulation of mast cell cytokine production" EXACT []
synonym: "up-regulation of mast cell cytokine production" EXACT []
synonym: "upregulation of mast cell cytokine production" EXACT []
is_a: GO:0002720 ! positive regulation of cytokine production during immune response
is_a: GO:0032763 ! regulation of mast cell cytokine production
relationship: positively_regulates GO:0032762 ! mast cell cytokine production

[Term]
id: GO:0032766
name: NHE3/E3KARP/ACTN4 complex
namespace: cellular_component
def: "A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments." [PMID:11948184]
synonym: " NHE3/E3KARP/alpha-actinin complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0032767
name: copper-dependent protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of copper." [GOC:ecd, PMID:16884690]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0032768
name: regulation of monooxygenase activity
namespace: biological_process
def: "Any process that modulates the activity of a monooxygenase." [GOC:mah]
subset: gosubset_prok
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:0032769
name: negative regulation of monooxygenase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a monooxygenase." [GOC:mah]
synonym: "down regulation of monooxygenase activity" EXACT []
synonym: "down-regulation of monooxygenase activity" EXACT []
synonym: "downregulation of monooxygenase activity" EXACT []
synonym: "inhibition of monooxygenase activity" NARROW []
is_a: GO:0032768 ! regulation of monooxygenase activity
is_a: GO:0051354 ! negative regulation of oxidoreductase activity

[Term]
id: GO:0032770
name: positive regulation of monooxygenase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a monooxygenase." [GOC:mah]
synonym: "activation of monooxygenase activity" NARROW []
synonym: "stimulation of monooxygenase activity" NARROW []
synonym: "up regulation of monooxygenase activity" EXACT []
synonym: "up-regulation of monooxygenase activity" EXACT []
synonym: "upregulation of monooxygenase activity" EXACT []
is_a: GO:0032768 ! regulation of monooxygenase activity
is_a: GO:0051353 ! positive regulation of oxidoreductase activity

[Term]
id: GO:0032771
name: regulation of monophenol monooxygenase activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme monophenol monooxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb, PMID:2494997]
synonym: "regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032768 ! regulation of monooxygenase activity

[Term]
id: GO:0032772
name: negative regulation of monophenol monooxygenase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme monophenol monooxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb]
synonym: "down regulation of monophenol oxygenase activity" EXACT []
synonym: "down-regulation of monophenol oxygenase activity" EXACT []
synonym: "downregulation of monophenol oxygenase activity" EXACT []
synonym: "inhibition of monophenol oxygenase activity" NARROW []
synonym: "negative regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb, PMID:2494997]
is_a: GO:0032769 ! negative regulation of monooxygenase activity
is_a: GO:0032771 ! regulation of monophenol monooxygenase activity

[Term]
id: GO:0032773
name: positive regulation of monophenol monooxygenase activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme monophenol oxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb, PMID:2494997]
synonym: "activation of monophenol oxygenase activity" NARROW []
synonym: "positive regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb, PMID:2494997]
synonym: "stimulation of monophenol oxygenase activity" NARROW []
synonym: "up regulation of monophenol oxygenase activity" EXACT []
synonym: "up-regulation of monophenol oxygenase activity" EXACT []
synonym: "upregulation of monophenol oxygenase activity" EXACT []
is_a: GO:0032770 ! positive regulation of monooxygenase activity
is_a: GO:0032771 ! regulation of monophenol monooxygenase activity

[Term]
id: GO:0032774
name: RNA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers." [GOC:mah]
synonym: "RNA anabolism" EXACT []
synonym: "RNA biosynthesis" EXACT []
synonym: "RNA formation" EXACT []
synonym: "RNA synthesis" EXACT []
is_a: GO:0016070 ! RNA metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0032775
name: DNA methylation on adenine
namespace: biological_process
def: "The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule." [GOC:pf]
synonym: "adenine methylation" RELATED []
is_a: GO:0006306 ! DNA methylation

[Term]
id: GO:0032776
name: DNA methylation on cytosine
namespace: biological_process
def: "The covalent transfer of a methyl group to C-5 or N-4 of cytosine in a DNA molecule." [GOC:pf]
synonym: "cytosine methylation" BROAD []
is_a: GO:0006306 ! DNA methylation

[Term]
id: GO:0032777
name: Piccolo NuA4 histone acetyltransferase complex
namespace: cellular_component
def: "A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p." [PMID:12782659, PMID:15964809]
is_a: GO:0043189 ! H4/H2A histone acetyltransferase complex

[Term]
id: GO:0032778
name: cobalt-transporting ATPase activity
namespace: molecular_function
alt_id: GO:0015632
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cobalt(out) = ADP + phosphate + cobalt(in)." [GOC:mlg, GOC:mtg_transport, ISBN:0815340729]
synonym: "cobalt ABC transporter" RELATED []
synonym: "cobalt porter activity" RELATED []
synonym: "cobalt transporting ATPase activity" EXACT []
is_a: GO:0015087 ! cobalt ion transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0032779
name: copper-induced intracellular protein transport
namespace: biological_process
def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell, induced by an increase in copper ion concentration." [GOC:ecd, PMID:12572677]
is_a: GO:0006886 ! intracellular protein transport

[Term]
id: GO:0032780
name: negative regulation of ATPase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of ATP hydrolysis by an ATPase." [GOC:mah]
synonym: "down regulation of ATPase activity" EXACT []
synonym: "down-regulation of ATPase activity" EXACT []
synonym: "downregulation of ATPase activity" EXACT []
synonym: "inhibition of ATPase activity" NARROW []
synonym: "negative regulation of adenosinetriphosphatase activity" EXACT []
is_a: GO:0043462 ! regulation of ATPase activity
is_a: GO:0051346 ! negative regulation of hydrolase activity

[Term]
id: GO:0032781
name: positive regulation of ATPase activity
namespace: biological_process
def: "Any process that activates or increases the rate of ATP hydrolysis by an ATPase." [GOC:mah]
synonym: "activation of ATPase activity" NARROW []
synonym: "positive regulation of adenosinetriphosphatase activity" EXACT []
synonym: "stimulation of ATPase activity" NARROW []
synonym: "up regulation of ATPase activity" EXACT []
synonym: "up-regulation of ATPase activity" EXACT []
synonym: "upregulation of ATPase activity" EXACT []
is_a: GO:0043462 ! regulation of ATPase activity
is_a: GO:0051345 ! positive regulation of hydrolase activity

[Term]
id: GO:0032782
name: bile acid secretion
namespace: biological_process
def: "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or group of cells." [GOC:ecd]
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0032783
name: ELL-EAF complex
namespace: cellular_component
def: "A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae." [PMID:17150956]
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0032784
name: regulation of RNA elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah]
synonym: "regulation of transcription elongation" BROAD []
synonym: "regulation of transcriptional elongation" BROAD []
is_a: GO:0006355 ! regulation of transcription, DNA-dependent
relationship: regulates GO:0006354 ! RNA elongation

[Term]
id: GO:0032785
name: negative regulation of RNA elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah]
synonym: "down regulation of RNA elongation" EXACT []
synonym: "down-regulation of RNA elongation" EXACT []
synonym: "downregulation of RNA elongation" EXACT []
synonym: "inhibition of RNA elongation" NARROW []
synonym: "negative regulation of transcription elongation" BROAD []
synonym: "negative regulation of transcriptional elongation" BROAD []
is_a: GO:0032784 ! regulation of RNA elongation
is_a: GO:0051253 ! negative regulation of RNA metabolic process
relationship: negatively_regulates GO:0006354 ! RNA elongation

[Term]
id: GO:0032786
name: positive regulation of RNA elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah]
synonym: "activation of RNA elongation" NARROW []
synonym: "positive regulation of transcription elongation" BROAD []
synonym: "positive regulation of transcriptional elongation" BROAD []
synonym: "stimulation of RNA elongation" NARROW []
synonym: "up regulation of RNA elongation" EXACT []
synonym: "up-regulation of RNA elongation" EXACT []
synonym: "upregulation of RNA elongation" EXACT []
is_a: GO:0032784 ! regulation of RNA elongation
is_a: GO:0051254 ! positive regulation of RNA metabolic process
relationship: positively_regulates GO:0006354 ! RNA elongation

[Term]
id: GO:0032787
name: monocarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk]
subset: gosubset_prok
synonym: "monocarboxylate metabolic process" EXACT []
synonym: "monocarboxylic acid metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0032788
name: saturated monocarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving saturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and fully saturated C-C bonds." [GOC:mah, GOC:vk]
synonym: "saturated monocarboxylate metabolic process" EXACT []
synonym: "saturated monocarboxylic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0032789
name: unsaturated monocarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds." [GOC:mah, GOC:vk]
synonym: "unsaturated monocarboxylate metabolic process" EXACT []
synonym: "unsaturated monocarboxylic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0032790
name: ribosome disassembly
namespace: biological_process
def: "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." [GOC:mah, GOC:vk]
synonym: "ribosome dissociation factor" RELATED []
is_a: GO:0032988 ! ribonucleoprotein complex disassembly

[Term]
id: GO:0032791
name: lead ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lead (Pb) ions." [GOC:mah]
subset: goslim_generic
subset: gosubset_prok
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0032792
name: negative regulation of CREB transcription factor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb]
synonym: "CREB inhibitor" RELATED []
synonym: "inhibition of CREB transcription factor" EXACT [GOC:dph, GOC:tb]
is_a: GO:0043433 ! negative regulation of transcription factor activity

[Term]
id: GO:0032793
name: positive regulation of CREB transcription factor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb]
synonym: "activation of CREB" EXACT []
synonym: "activation of CREB transcription factor" EXACT [GOC:dph, GOC:tb]
synonym: "CREB activator" RELATED []
is_a: GO:0051091 ! positive regulation of transcription factor activity

[Term]
id: GO:0032794
name: GTPase activating protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a GTPase activating protein." [GOC:nln]
synonym: "GAP binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0032795
name: heterotrimeric G-protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a heterotrimeric G-protein." [GOC:nln]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0032796
name: uropod organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12714569, PMID:12787750]
synonym: "uropod organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0032797
name: SMN complex
namespace: cellular_component
def: "A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415]
comment: Note that a larger complex containing Sm proteins and other subunits is also sometimes referred to as the 'SMN complex'. The larger complex is represented by 'SMN-Sm protein complex ; GO:0034719'.
synonym: "SMN core complex" EXACT []
synonym: "survival motor neuron complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0032798
name: Swi5-Sfr1 complex
namespace: cellular_component
def: "A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces)." [PMID:15620352, PMID:16921379]
comment: Note that this term refers to Schizosaccharomyces pombe Swi5, which should not be confused with the unrelated Saccharomyces Swi5p.
synonym: "Sae3-Mei5 complex" EXACT [GOC:elh, GOC:vw]
synonym: "Swi5 complex" BROAD []
is_a: GO:0033061 ! DNA recombinase mediator complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0032799
name: low-density lipoprotein receptor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving low-density lipoprotein receptors." [GOC:vk]
synonym: "LDL receptor metabolic process" EXACT []
synonym: "low-density lipoprotein receptor metabolism" EXACT []
is_a: GO:0043112 ! receptor metabolic process

[Term]
id: GO:0032800
name: receptor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah]
synonym: "receptor anabolism" EXACT []
synonym: "receptor biosynthesis" EXACT []
synonym: "receptor formation" EXACT []
synonym: "receptor synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0043112 ! receptor metabolic process

[Term]
id: GO:0032801
name: receptor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah]
synonym: "receptor breakdown" EXACT []
synonym: "receptor catabolism" EXACT []
synonym: "receptor degradation" EXACT []
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0043112 ! receptor metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0032802
name: low-density lipoprotein receptor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah]
synonym: "LDL receptor breakdown" EXACT []
synonym: "LDL receptor catabolic process" EXACT []
synonym: "LDL receptor catabolism" RELATED []
synonym: "LDL receptor degradation" EXACT []
synonym: "low-density lipoprotein receptor breakdown" EXACT []
synonym: "low-density lipoprotein receptor catabolism" EXACT []
synonym: "low-density lipoprotein receptor degradation" EXACT []
is_a: GO:0032799 ! low-density lipoprotein receptor metabolic process
is_a: GO:0032801 ! receptor catabolic process
is_a: GO:0044257 ! cellular protein catabolic process

[Term]
id: GO:0032803
name: regulation of low-density lipoprotein receptor catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors." [GOC:mah]
synonym: "regulation of LDLr catabolic process" EXACT []
synonym: "regulation of LDLr catabolism" EXACT []
synonym: "regulation of low-density lipoprotein receptor breakdown" EXACT []
synonym: "regulation of low-density lipoprotein receptor catabolism" EXACT []
synonym: "regulation of low-density lipoprotein receptor degradation" EXACT []
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
relationship: regulates GO:0032802 ! low-density lipoprotein receptor catabolic process

[Term]
id: GO:0032804
name: negative regulation of low-density lipoprotein receptor catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors." [GOC:mah]
synonym: "down regulation of low-density lipoprotein receptor catabolic process" EXACT []
synonym: "down-regulation of low-density lipoprotein receptor catabolic process" EXACT []
synonym: "downregulation of low-density lipoprotein receptor catabolic process" EXACT []
synonym: "inhibition of low-density lipoprotein receptor catabolic process" NARROW []
synonym: "negative regulation of low-density lipoprotein receptor breakdown" EXACT []
synonym: "negative regulation of low-density lipoprotein receptor catabolism" EXACT []
synonym: "negative regulation of low-density lipoprotein receptor degradation" EXACT []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0032269 ! negative regulation of cellular protein metabolic process
is_a: GO:0032803 ! regulation of low-density lipoprotein receptor catabolic process
is_a: GO:0042177 ! negative regulation of protein catabolic process
relationship: negatively_regulates GO:0032802 ! low-density lipoprotein receptor catabolic process

[Term]
id: GO:0032805
name: positive regulation of low-density lipoprotein receptor catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors." [GOC:mah]
synonym: "activation of low-density lipoprotein receptor catabolic process" NARROW []
synonym: "positive regulation of low-density lipoprotein receptor breakdown" EXACT []
synonym: "positive regulation of low-density lipoprotein receptor catabolism" EXACT []
synonym: "positive regulation of low-density lipoprotein receptor degradation" EXACT []
synonym: "stimulation of low-density lipoprotein receptor catabolic process" NARROW []
synonym: "up regulation of low-density lipoprotein receptor catabolic process" EXACT []
synonym: "up-regulation of low-density lipoprotein receptor catabolic process" EXACT []
synonym: "upregulation of low-density lipoprotein receptor catabolic process" EXACT []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0032270 ! positive regulation of cellular protein metabolic process
is_a: GO:0032803 ! regulation of low-density lipoprotein receptor catabolic process
is_a: GO:0045732 ! positive regulation of protein catabolic process
relationship: positively_regulates GO:0032802 ! low-density lipoprotein receptor catabolic process

[Term]
id: GO:0032806
name: carboxy-terminal domain protein kinase complex
namespace: cellular_component
def: "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683]
synonym: "CTDK complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032807
name: DNA ligase IV complex
namespace: cellular_component
def: "A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p." [PMID:16314503]
synonym: "DNA ligase IV-XRCC4 complex" EXACT [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0032808
name: lacrimal gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye." [GOC:ln]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035272 ! exocrine system development

[Term]
id: GO:0032809
name: neuronal cell body membrane
namespace: cellular_component
def: "The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites." [GOC:jl]
synonym: "neuron cell body membrane" EXACT []
synonym: "neuronal cell soma membrane" EXACT []
is_a: GO:0044298 ! cell body membrane
relationship: part_of GO:0043025 ! neuronal cell body

[Term]
id: GO:0032810
name: sterol response element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism." [GOC:vk, PMID:11994399]
synonym: "SRE binding" EXACT []
is_a: GO:0010843 ! promoter binding

[Term]
id: GO:0032811
name: negative regulation of epinephrine secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk]
synonym: "down regulation of epinephrine secretion" EXACT []
synonym: "down-regulation of epinephrine secretion" EXACT []
synonym: "downregulation of epinephrine secretion" EXACT []
synonym: "inhibition of epinephrine secretion" NARROW []
synonym: "negative regulation of adrenaline secretion" EXACT []
is_a: GO:0014060 ! regulation of epinephrine secretion
is_a: GO:0033604 ! negative regulation of catecholamine secretion
relationship: negatively_regulates GO:0048242 ! epinephrine secretion

[Term]
id: GO:0032812
name: positive regulation of epinephrine secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk]
synonym: "activation of epinephrine secretion" NARROW []
synonym: "positive regulation of adrenaline secretion" EXACT []
synonym: "stimulation of epinephrine secretion" NARROW []
synonym: "up regulation of epinephrine secretion" EXACT []
synonym: "up-regulation of epinephrine secretion" EXACT []
synonym: "upregulation of epinephrine secretion" EXACT []
is_a: GO:0014060 ! regulation of epinephrine secretion
is_a: GO:0033605 ! positive regulation of catecholamine secretion
relationship: positively_regulates GO:0048242 ! epinephrine secretion

[Term]
id: GO:0032813
name: tumor necrosis factor receptor superfamily binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily." [GOC:add]
synonym: "TNF receptor superfamily binding" EXACT []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0032814
name: regulation of natural killer cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell activation." [GOC:mah]
synonym: "regulation of NK cell activation" EXACT []
is_a: GO:0051249 ! regulation of lymphocyte activation
relationship: regulates GO:0030101 ! natural killer cell activation

[Term]
id: GO:0032815
name: negative regulation of natural killer cell activation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation." [GOC:mah]
synonym: "down regulation of natural killer cell activation" EXACT []
synonym: "down-regulation of natural killer cell activation" EXACT []
synonym: "downregulation of natural killer cell activation" EXACT []
synonym: "inhibition of natural killer cell activation" NARROW []
synonym: "negative regulation of NK cell activation" EXACT []
is_a: GO:0032814 ! regulation of natural killer cell activation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
relationship: negatively_regulates GO:0030101 ! natural killer cell activation

[Term]
id: GO:0032816
name: positive regulation of natural killer cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell activation." [GOC:mah]
synonym: "activation of natural killer cell activation" NARROW []
synonym: "positive regulation of NK cell activation" EXACT []
synonym: "stimulation of natural killer cell activation" NARROW []
synonym: "up regulation of natural killer cell activation" EXACT []
synonym: "up-regulation of natural killer cell activation" EXACT []
synonym: "upregulation of natural killer cell activation" EXACT []
is_a: GO:0032814 ! regulation of natural killer cell activation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
relationship: positively_regulates GO:0030101 ! natural killer cell activation

[Term]
id: GO:0032817
name: regulation of natural killer cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation." [GOC:mah]
synonym: "regulation of NK cell proliferation" EXACT []
is_a: GO:0032814 ! regulation of natural killer cell activation
is_a: GO:0050670 ! regulation of lymphocyte proliferation
relationship: regulates GO:0001787 ! natural killer cell proliferation

[Term]
id: GO:0032818
name: negative regulation of natural killer cell proliferation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation." [GOC:mah]
synonym: "down regulation of natural killer cell proliferation" EXACT []
synonym: "down-regulation of natural killer cell proliferation" EXACT []
synonym: "downregulation of natural killer cell proliferation" EXACT []
synonym: "inhibition of natural killer cell proliferation" NARROW []
synonym: "negative regulation of NK cell proliferation" EXACT []
is_a: GO:0032815 ! negative regulation of natural killer cell activation
is_a: GO:0032817 ! regulation of natural killer cell proliferation
is_a: GO:0050672 ! negative regulation of lymphocyte proliferation
relationship: negatively_regulates GO:0001787 ! natural killer cell proliferation

[Term]
id: GO:0032819
name: positive regulation of natural killer cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation." [GOC:mah]
synonym: "activation of natural killer cell proliferation" NARROW []
synonym: "positive regulation of NK cell proliferation" EXACT []
synonym: "stimulation of natural killer cell proliferation" NARROW []
synonym: "up regulation of natural killer cell proliferation" EXACT []
synonym: "up-regulation of natural killer cell proliferation" EXACT []
synonym: "upregulation of natural killer cell proliferation" EXACT []
is_a: GO:0032816 ! positive regulation of natural killer cell activation
is_a: GO:0032817 ! regulation of natural killer cell proliferation
is_a: GO:0050671 ! positive regulation of lymphocyte proliferation
relationship: positively_regulates GO:0001787 ! natural killer cell proliferation

[Term]
id: GO:0032820
name: regulation of natural killer cell proliferation during immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation during an immune response." [GOC:mah]
synonym: "regulation of NK cell proliferation during immune response" EXACT []
is_a: GO:0032817 ! regulation of natural killer cell proliferation
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002324 ! natural killer cell proliferation during immune response

[Term]
id: GO:0032821
name: negative regulation of natural killer cell proliferation during immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation during an immune response." [GOC:mah]
synonym: "down regulation of natural killer cell proliferation during immune response" EXACT []
synonym: "down-regulation of natural killer cell proliferation during immune response" EXACT []
synonym: "downregulation of natural killer cell proliferation during immune response" EXACT []
synonym: "inhibition of natural killer cell proliferation during immune response" NARROW []
synonym: "negative regulation of NK cell proliferation during immune response" EXACT []
is_a: GO:0032818 ! negative regulation of natural killer cell proliferation
is_a: GO:0032820 ! regulation of natural killer cell proliferation during immune response
relationship: negatively_regulates GO:0002324 ! natural killer cell proliferation during immune response

[Term]
id: GO:0032822
name: positive regulation of natural killer cell proliferation during immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation during an immune response." [GOC:mah]
synonym: "activation of natural killer cell proliferation during immune response" NARROW []
synonym: "positive regulation of NK cell proliferation during immune response" EXACT []
synonym: "stimulation of natural killer cell proliferation during immune response" NARROW []
synonym: "up regulation of natural killer cell proliferation during immune response" EXACT []
synonym: "up-regulation of natural killer cell proliferation during immune response" EXACT []
synonym: "upregulation of natural killer cell proliferation during immune response" EXACT []
is_a: GO:0032819 ! positive regulation of natural killer cell proliferation
is_a: GO:0032820 ! regulation of natural killer cell proliferation during immune response
relationship: positively_regulates GO:0002324 ! natural killer cell proliferation during immune response

[Term]
id: GO:0032823
name: regulation of natural killer cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation." [GOC:mah]
synonym: "regulation of NK cell differentiation" EXACT []
is_a: GO:0032814 ! regulation of natural killer cell activation
is_a: GO:0045619 ! regulation of lymphocyte differentiation
relationship: regulates GO:0001779 ! natural killer cell differentiation

[Term]
id: GO:0032824
name: negative regulation of natural killer cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation." [GOC:mah]
synonym: "down regulation of natural killer cell differentiation" EXACT []
synonym: "down-regulation of natural killer cell differentiation" EXACT []
synonym: "downregulation of natural killer cell differentiation" EXACT []
synonym: "inhibition of natural killer cell differentiation" NARROW []
synonym: "negative regulation of NK cell differentiation" EXACT []
is_a: GO:0032815 ! negative regulation of natural killer cell activation
is_a: GO:0032823 ! regulation of natural killer cell differentiation
is_a: GO:0045620 ! negative regulation of lymphocyte differentiation
relationship: negatively_regulates GO:0001779 ! natural killer cell differentiation

[Term]
id: GO:0032825
name: positive regulation of natural killer cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation." [GOC:mah]
synonym: "activation of natural killer cell differentiation" NARROW []
synonym: "positive regulation of NK cell differentiation" EXACT []
synonym: "stimulation of natural killer cell differentiation" NARROW []
synonym: "up regulation of natural killer cell differentiation" EXACT []
synonym: "up-regulation of natural killer cell differentiation" EXACT []
synonym: "upregulation of natural killer cell differentiation" EXACT []
is_a: GO:0032816 ! positive regulation of natural killer cell activation
is_a: GO:0032823 ! regulation of natural killer cell differentiation
is_a: GO:0045621 ! positive regulation of lymphocyte differentiation
relationship: positively_regulates GO:0001779 ! natural killer cell differentiation

[Term]
id: GO:0032826
name: regulation of natural killer cell differentiation during immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation during an immune response." [GOC:mah]
synonym: "regulation of NK cell differentiation during immune response" EXACT []
is_a: GO:0032823 ! regulation of natural killer cell differentiation
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002325 ! natural killer cell differentiation during immune response

[Term]
id: GO:0032827
name: negative regulation of natural killer cell differentiation during immune response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation during an immune response." [GOC:mah]
synonym: "down regulation of natural killer cell differentiation during immune response" EXACT []
synonym: "down-regulation of natural killer cell differentiation during immune response" EXACT []
synonym: "downregulation of natural killer cell differentiation during immune response" EXACT []
synonym: "inhibition of natural killer cell differentiation during immune response" NARROW []
synonym: "negative regulation of NK cell differentiation during immune response" EXACT []
is_a: GO:0032824 ! negative regulation of natural killer cell differentiation
is_a: GO:0032826 ! regulation of natural killer cell differentiation during immune response
relationship: negatively_regulates GO:0002325 ! natural killer cell differentiation during immune response

[Term]
id: GO:0032828
name: positive regulation of natural killer cell differentiation during immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation during an immune response." [GOC:mah]
synonym: "activation of natural killer cell differentiation during immune response" NARROW []
synonym: "positive regulation of NK cell differentiation during immune response" EXACT []
synonym: "stimulation of natural killer cell differentiation during immune response" NARROW []
synonym: "up regulation of natural killer cell differentiation during immune response" EXACT []
synonym: "up-regulation of natural killer cell differentiation during immune response" EXACT []
synonym: "upregulation of natural killer cell differentiation during immune response" EXACT []
is_a: GO:0032825 ! positive regulation of natural killer cell differentiation
is_a: GO:0032826 ! regulation of natural killer cell differentiation during immune response
relationship: positively_regulates GO:0002325 ! natural killer cell differentiation during immune response

[Term]
id: GO:0032829
name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah]
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
is_a: GO:0043370 ! regulation of CD4-positive, alpha beta T cell differentiation
is_a: GO:0045589 ! regulation of regulatory T cell differentiation
relationship: regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

[Term]
id: GO:0032830
name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah]
synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
is_a: GO:0043371 ! negative regulation of CD4-positive, alpha beta T cell differentiation
is_a: GO:0045590 ! negative regulation of regulatory T cell differentiation
relationship: negatively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

[Term]
id: GO:0032831
name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah]
synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT []
synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW []
synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT []
is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
is_a: GO:0043372 ! positive regulation of CD4-positive, alpha beta T cell differentiation
is_a: GO:0045591 ! positive regulation of regulatory T cell differentiation
relationship: positively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

[Term]
id: GO:0032832
name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells during an immune response." [GOC:mah]
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" EXACT []
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" EXACT []
synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" EXACT []
is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response

[Term]
id: GO:0032833
name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells during an immune response." [GOC:mah]
synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" EXACT []
synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" EXACT []
synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" EXACT []
synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" EXACT []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" EXACT []
synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" EXACT []
is_a: GO:0032830 ! negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response
relationship: negatively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response

[Term]
id: GO:0032834
name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells during an immune response." [GOC:mah]
synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" EXACT []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" EXACT []
synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" EXACT []
synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW []
synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" EXACT []
synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" EXACT []
synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" EXACT []
is_a: GO:0032831 ! positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response
relationship: positively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response

[Term]
id: GO:0032835
name: glomerulus development
namespace: biological_process
def: "The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:mah]
synonym: "glomerular development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0032836
name: glomerular basement membrane development
namespace: biological_process
def: "The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration." [GOC:sr]
is_a: GO:0030198 ! extracellular matrix organization
relationship: part_of GO:0032835 ! glomerulus development

[Term]
id: GO:0032837
name: distributive segregation
namespace: biological_process
def: "The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a \"backup\" mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally." [GOC:expert_rsh, GOC:ma, GOC:sart]
is_a: GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0032838
name: cell projection cytoplasm
namespace: cellular_component
def: "All of the contents of a cell projection, excluding the plasma membrane surrounding the projection." [GOC:mah]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044463 ! cell projection part

[Term]
id: GO:0032839
name: dendrite cytoplasm
namespace: cellular_component
def: "All of the contents of a dendrite, excluding the surrounding plasma membrane." [GOC:mah]
synonym: "dendritic cytoplasm" EXACT []
is_a: GO:0032838 ! cell projection cytoplasm
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:0032840
name: intramolecular proline-rich ligand binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a proline-rich region within the same polypeptide." [GOC:pf]
synonym: "intramolecular proline-rich region binding" EXACT []
is_a: GO:0043621 ! protein self-association
is_a: GO:0070064 ! proline-rich region binding

[Term]
id: GO:0032841
name: calcitonin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid." [GOC:ecd]
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0032843
name: hydroperoxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction:2RSH + ROOH = RSSR + ROH + H2O, i.e. the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol plus water." [GOC:mlg, PMID:12540833]
is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0032844
name: regulation of homeostatic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a homeostatic process." [GOC:mah]
subset: gosubset_prok
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0042592 ! homeostatic process

[Term]
id: GO:0032845
name: negative regulation of homeostatic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a homeostatic process." [GOC:mah]
synonym: "down regulation of homeostatic process" EXACT []
synonym: "down-regulation of homeostatic process" EXACT []
synonym: "downregulation of homeostatic process" EXACT []
synonym: "inhibition of homeostatic process" NARROW []
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0042592 ! homeostatic process

[Term]
id: GO:0032846
name: positive regulation of homeostatic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a homeostatic process." [GOC:mah]
synonym: "activation of homeostatic process" NARROW []
synonym: "stimulation of homeostatic process" NARROW []
synonym: "up regulation of homeostatic process" EXACT []
synonym: "up-regulation of homeostatic process" EXACT []
synonym: "upregulation of homeostatic process" EXACT []
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0042592 ! homeostatic process

[Term]
id: GO:0032847
name: regulation of cellular pH reduction
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah]
synonym: "regulation of cell pH reduction" EXACT []
synonym: "regulation of cellular acidification" EXACT []
synonym: "regulation of intracellular acidification" RELATED []
synonym: "regulation of intracellular pH reduction" EXACT []
synonym: "regulation of reduction of cellular pH" EXACT []
synonym: "regulation of reduction of pH in cell" EXACT []
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0051452 ! intracellular pH reduction

[Term]
id: GO:0032848
name: negative regulation of cellular pH reduction
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah]
synonym: "down regulation of cellular pH reduction" EXACT []
synonym: "down-regulation of cellular pH reduction" EXACT []
synonym: "downregulation of cellular pH reduction" EXACT []
synonym: "inhibition of cellular pH reduction" NARROW []
synonym: "negative regulation of cell pH reduction" EXACT []
synonym: "negative regulation of cellular acidification" EXACT []
synonym: "negative regulation of intracellular acidification" RELATED []
synonym: "negative regulation of intracellular pH reduction" EXACT []
synonym: "negative regulation of reduction of cellular pH" EXACT []
synonym: "negative regulation of reduction of pH in cell" EXACT []
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0032847 ! regulation of cellular pH reduction
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0051452 ! intracellular pH reduction

[Term]
id: GO:0032849
name: positive regulation of cellular pH reduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah]
synonym: "activation of cellular pH reduction" NARROW []
synonym: "positive regulation of cell pH reduction" EXACT []
synonym: "positive regulation of cellular acidification" EXACT []
synonym: "positive regulation of intracellular acidification" RELATED []
synonym: "positive regulation of intracellular pH reduction" EXACT []
synonym: "positive regulation of reduction of cellular pH" EXACT []
synonym: "positive regulation of reduction of pH in cell" EXACT []
synonym: "stimulation of cellular pH reduction" NARROW []
synonym: "up regulation of cellular pH reduction" EXACT []
synonym: "up-regulation of cellular pH reduction" EXACT []
synonym: "upregulation of cellular pH reduction" EXACT []
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0032847 ! regulation of cellular pH reduction
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0051452 ! intracellular pH reduction

[Term]
id: GO:0032850
name: positive regulation of ARF GTPase activity
namespace: biological_process
def: "Any process that activates or increases the activity of the GTPase ARF." [GOC:mah]
synonym: "stimulation of ARF GTPase activity" NARROW []
synonym: "up regulation of ARF GTPase activity" EXACT []
synonym: "up-regulation of ARF GTPase activity" EXACT []
synonym: "upregulation of ARF GTPase activity" EXACT []
is_a: GO:0032312 ! regulation of ARF GTPase activity
is_a: GO:0032320 ! positive regulation of Ras GTPase activity

[Term]
id: GO:0032851
name: positive regulation of Rab GTPase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a GTPase of the Rab family." [GOC:mah]
synonym: "stimulation of Rab GTPase activity" NARROW []
synonym: "up regulation of Rab GTPase activity" EXACT []
synonym: "up-regulation of Rab GTPase activity" EXACT []
synonym: "upregulation of Rab GTPase activity" EXACT []
is_a: GO:0032313 ! regulation of Rab GTPase activity
is_a: GO:0032320 ! positive regulation of Ras GTPase activity

[Term]
id: GO:0032852
name: positive regulation of Ral GTPase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a GTPase of the Ral family." [GOC:mah]
synonym: "stimulation of Ral GTPase activity" NARROW []
synonym: "up regulation of Ral GTPase activity" EXACT []
synonym: "up-regulation of Ral GTPase activity" EXACT []
synonym: "upregulation of Ral GTPase activity" EXACT []
is_a: GO:0032315 ! regulation of Ral GTPase activity
is_a: GO:0032320 ! positive regulation of Ras GTPase activity

[Term]
id: GO:0032853
name: positive regulation of Ran GTPase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a GTPase of the Ran family." [GOC:mah]
synonym: "stimulation of Ran GTPase activity" NARROW []
synonym: "up regulation of Ran GTPase activity" EXACT []
synonym: "up-regulation of Ran GTPase activity" EXACT []
synonym: "upregulation of Ran GTPase activity" EXACT []
is_a: GO:0032316 ! regulation of Ran GTPase activity
is_a: GO:0032320 ! positive regulation of Ras GTPase activity

[Term]
id: GO:0032854
name: positive regulation of Rap GTPase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a GTPase of the Rap family." [GOC:mah]
synonym: "stimulation of Rap GTPase activity" NARROW []
synonym: "up regulation of Rap GTPase activity" EXACT []
synonym: "up-regulation of Rap GTPase activity" EXACT []
synonym: "upregulation of Rap GTPase activity" EXACT []
is_a: GO:0032317 ! regulation of Rap GTPase activity
is_a: GO:0032320 ! positive regulation of Ras GTPase activity

[Term]
id: GO:0032855
name: positive regulation of Rac GTPase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a GTPase of the Rac family." [GOC:mah]
synonym: "stimulation of Rac GTPase activity" NARROW []
synonym: "up regulation of Rac GTPase activity" EXACT []
synonym: "up-regulation of Rac GTPase activity" EXACT []
synonym: "upregulation of Rac GTPase activity" EXACT []
is_a: GO:0032321 ! positive regulation of Rho GTPase activity

[Term]
id: GO:0032856
name: activation of Ras GTPase activity
namespace: biological_process
def: "Any process that initiates the activity of an inactive GTPase of the Ras superfamily through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]
comment: Note that this term should not be confused with the molecular function term 'Ras GTPase activator activity ; GO:0005099', which refers specifically to the activity of Ras GAPs.
synonym: "Ras GTPase activation" EXACT []
is_a: GO:0032320 ! positive regulation of Ras GTPase activity

[Term]
id: GO:0032857
name: activation of ARF GTPase activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme ARF GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]
comment: Note that this term should not be confused with the molecular function term 'ARF GTPase activator activity ; GO:0008060', which refers specifically to the activity of ARF GAPs.
synonym: "ARF GTPase activation" EXACT []
is_a: GO:0032850 ! positive regulation of ARF GTPase activity
is_a: GO:0032856 ! activation of Ras GTPase activity

[Term]
id: GO:0032858
name: activation of Rab GTPase activity
namespace: biological_process
def: "Any process that initiates the activity of an inactive GTPase of the Rab family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]
comment: Note that this term should not be confused with the molecular function term 'Rab GTPase activator activity ; GO:0005097', which refers specifically to the activity of Rab GAPs.
synonym: "Rab GTPase activation" EXACT []
is_a: GO:0032851 ! positive regulation of Rab GTPase activity
is_a: GO:0032856 ! activation of Ras GTPase activity

[Term]
id: GO:0032859
name: activation of Ral GTPase activity
namespace: biological_process
def: "Any process that initiates the activity of an inactive GTPase of the Ral family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]
comment: Note that this term should not be confused with the molecular function term 'Ral GTPase activator activity ; GO:0017123', which refers specifically to the activity of Ral GAPs.
synonym: "Ral GTPase activation" EXACT []
is_a: GO:0032852 ! positive regulation of Ral GTPase activity
is_a: GO:0032856 ! activation of Ras GTPase activity

[Term]
id: GO:0032860
name: activation of Ran GTPase activity
namespace: biological_process
def: "Any process that initiates the activity of an inactive GTPase of the Ran family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]
comment: Note that this term should not be confused with the molecular function term 'Ran GTPase activator activity ; GO:0005098', which refers specifically to the activity of Ran GAPs.
synonym: "Ran GTPase activation" EXACT []
is_a: GO:0032853 ! positive regulation of Ran GTPase activity
is_a: GO:0032856 ! activation of Ras GTPase activity

[Term]
id: GO:0032861
name: activation of Rap GTPase activity
namespace: biological_process
def: "Any process that initiates the activity of an inactive GTPase of the Rap family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]
comment: Note that this term should not be confused with the molecular function term 'Rap GTPase activator activity ; GO:0046582', which refers specifically to the activity of Rap GAPs.
synonym: "Rap GTPase activation" EXACT []
is_a: GO:0032854 ! positive regulation of Rap GTPase activity
is_a: GO:0032856 ! activation of Ras GTPase activity

[Term]
id: GO:0032862
name: activation of Rho GTPase activity
namespace: biological_process
def: "Any process that initiates the activity of an inactive GTPase of the Rho family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]
comment: Note that this term should not be confused with the molecular function term 'Rho GTPase activator activity ; GO:0005100', which refers specifically to the activity of Rho GAPs.
synonym: "Rho GTPase activation" EXACT []
is_a: GO:0032321 ! positive regulation of Rho GTPase activity
is_a: GO:0032856 ! activation of Ras GTPase activity

[Term]
id: GO:0032863
name: activation of Rac GTPase activity
namespace: biological_process
def: "Any process that initiates the activity of an inactive GTPase of the Rac family through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb]
synonym: "Rac GTPase activation" EXACT []
is_a: GO:0032855 ! positive regulation of Rac GTPase activity
is_a: GO:0032862 ! activation of Rho GTPase activity

[Term]
id: GO:0032864
name: activation of Cdc42 GTPase activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive GTPase Cdc42 through the replacement of GDP by GTP." [GOC:mah]
synonym: "Cdc42 GTPase activation" EXACT []
is_a: GO:0032862 ! activation of Rho GTPase activity
is_a: GO:0043089 ! positive regulation of Cdc42 GTPase activity

[Term]
id: GO:0032865
name: ERMES complex
namespace: cellular_component
def: "A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. The complex is also associated with actively replicating mitochondrial DNA nucleoids, and may further coordinate mitochondrial genome replication and membrane growth." [GOC:mcc, PMID:19556461]
synonym: "ER-mitochondria encounter structure" EXACT []
synonym: "Mdm10/Mdm12/Mmm1 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005741 ! mitochondrial outer membrane
relationship: part_of GO:0044233 ! ER-mitochondrion membrane contact site

[Term]
id: GO:0032866
name: xylose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+." [PMID:12724380, PMID:15184173]
is_a: GO:0004032 ! aldehyde reductase activity

[Term]
id: GO:0032867
name: arabinose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+." [PMID:12724380, PMID:15184173]
is_a: GO:0004032 ! aldehyde reductase activity

[Term]
id: GO:0032868
name: response to insulin stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0043434 ! response to peptide hormone stimulus

[Term]
id: GO:0032869
name: cellular response to insulin stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0032868 ! response to insulin stimulus
is_a: GO:0071375 ! cellular response to peptide hormone stimulus

[Term]
id: GO:0032870
name: cellular response to hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah]
is_a: GO:0009725 ! response to hormone stimulus
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0071495 ! cellular response to endogenous stimulus

[Term]
id: GO:0032871
name: regulation of karyogamy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion." [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0000741 ! karyogamy

[Term]
id: GO:0032872
name: regulation of stress-activated MAPK cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah]
synonym: "regulation of p38 MAPK signaling" EXACT []
synonym: "regulation of p38 MAPK signalling" EXACT []
synonym: "regulation of stress-activated MAPK signaling pathway" EXACT []
synonym: "regulation of stress-activated MAPK signalling pathway" EXACT []
synonym: "regulation of stress-activated MAPKKK cascade" EXACT []
synonym: "regulation of stress-activated MAPKKK signaling pathway" EXACT []
synonym: "regulation of stress-activated MAPKKK signalling pathway" EXACT []
is_a: GO:0043408 ! regulation of MAPKKK cascade
is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling pathway
relationship: regulates GO:0051403 ! stress-activated MAPK cascade

[Term]
id: GO:0032873
name: negative regulation of stress-activated MAPK cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah]
synonym: "down regulation of stress-activated MAPK cascade" EXACT []
synonym: "down-regulation of stress-activated MAPK cascade" EXACT []
synonym: "downregulation of stress-activated MAPK cascade" EXACT []
synonym: "inhibition of stress-activated MAPK cascade" NARROW []
synonym: "negative regulation of p38 MAPK signaling" EXACT []
synonym: "negative regulation of p38 MAPK signalling" EXACT []
synonym: "negative regulation of stress-activated MAPK signaling pathway" EXACT []
synonym: "negative regulation of stress-activated MAPK signalling pathway" EXACT []
synonym: "negative regulation of stress-activated MAPKKK cascade" EXACT []
synonym: "negative regulation of stress-activated MAPKKK signaling pathway" EXACT []
synonym: "negative regulation of stress-activated MAPKKK signalling pathway" EXACT []
is_a: GO:0032872 ! regulation of stress-activated MAPK cascade
is_a: GO:0043409 ! negative regulation of MAPKKK cascade
is_a: GO:0070303 ! negative regulation of stress-activated protein kinase signaling pathway
relationship: negatively_regulates GO:0051403 ! stress-activated MAPK cascade

[Term]
id: GO:0032874
name: positive regulation of stress-activated MAPK cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah]
synonym: "activation of stress-activated MAPK cascade" NARROW []
synonym: "positive regulation of p38 MAPK signaling" EXACT []
synonym: "positive regulation of p38 MAPK signalling" EXACT []
synonym: "positive regulation of stress-activated MAPK signaling pathway" EXACT []
synonym: "positive regulation of stress-activated MAPK signalling pathway" EXACT []
synonym: "positive regulation of stress-activated MAPKKK cascade" EXACT []
synonym: "positive regulation of stress-activated MAPKKK signaling pathway" EXACT []
synonym: "positive regulation of stress-activated MAPKKK signalling pathway" EXACT []
synonym: "stimulation of stress-activated MAPK cascade" NARROW []
synonym: "up regulation of stress-activated MAPK cascade" EXACT []
synonym: "up-regulation of stress-activated MAPK cascade" EXACT []
synonym: "upregulation of stress-activated MAPK cascade" EXACT []
is_a: GO:0032872 ! regulation of stress-activated MAPK cascade
is_a: GO:0043410 ! positive regulation of MAPKKK cascade
is_a: GO:0070304 ! positive regulation of stress-activated protein kinase signaling pathway
relationship: positively_regulates GO:0051403 ! stress-activated MAPK cascade

[Term]
id: GO:0032875
name: regulation of DNA endoreduplication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA endoreduplication." [GOC:mah]
synonym: "regulation of DNA endoreplication" EXACT []
synonym: "regulation of DNA re-duplication" EXACT []
is_a: GO:0006275 ! regulation of DNA replication
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0042023 ! DNA endoreduplication

[Term]
id: GO:0032876
name: negative regulation of DNA endoreduplication
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication." [GOC:mah]
synonym: "down regulation of DNA endoreduplication" EXACT []
synonym: "down-regulation of DNA endoreduplication" EXACT []
synonym: "downregulation of DNA endoreduplication" EXACT []
synonym: "inhibition of DNA endoreduplication" NARROW []
synonym: "negative regulation of DNA endoreplication" EXACT []
synonym: "negative regulation of DNA re-duplication" EXACT []
is_a: GO:0008156 ! negative regulation of DNA replication
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0032875 ! regulation of DNA endoreduplication
relationship: negatively_regulates GO:0042023 ! DNA endoreduplication

[Term]
id: GO:0032877
name: positive regulation of DNA endoreduplication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA endoreduplication." [GOC:mah]
synonym: "activation of DNA endoreduplication" NARROW []
synonym: "positive regulation of DNA endoreplication" EXACT []
synonym: "positive regulation of DNA re-duplication" EXACT []
synonym: "stimulation of DNA endoreduplication" NARROW []
synonym: "up regulation of DNA endoreduplication" EXACT []
synonym: "up-regulation of DNA endoreduplication" EXACT []
synonym: "upregulation of DNA endoreduplication" EXACT []
is_a: GO:0032875 ! regulation of DNA endoreduplication
is_a: GO:0045740 ! positive regulation of DNA replication
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0042023 ! DNA endoreduplication

[Term]
id: GO:0032878
name: regulation of establishment or maintenance of cell polarity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah]
is_a: GO:0022604 ! regulation of cell morphogenesis
relationship: regulates GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0032879
name: regulation of localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah]
subset: gosubset_prok
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0051179 ! localization

[Term]
id: GO:0032880
name: regulation of protein localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any process by which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb]
subset: gosubset_prok
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0008104 ! protein localization

[Term]
id: GO:0032881
name: regulation of polysaccharide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." [GOC:mah]
subset: gosubset_prok
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0032882
name: regulation of chitin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin." [GOC:mah]
synonym: "regulation of chitin metabolism" EXACT []
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
relationship: regulates GO:0006030 ! chitin metabolic process

[Term]
id: GO:0032883
name: regulation of chitin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chitin." [GOC:mah]
synonym: "regulation of chitin anabolism" EXACT []
synonym: "regulation of chitin biosynthesis" RELATED []
synonym: "regulation of chitin formation" EXACT []
synonym: "regulation of chitin synthesis" EXACT []
is_a: GO:0032882 ! regulation of chitin metabolic process
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
relationship: regulates GO:0006031 ! chitin biosynthetic process

[Term]
id: GO:0032884
name: regulation of cell wall chitin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cell wall chitin." [GOC:mah]
synonym: "regulation of cell wall chitin anabolism" EXACT []
synonym: "regulation of cell wall chitin biosynthesis" EXACT []
synonym: "regulation of cell wall chitin formation" EXACT []
synonym: "regulation of cell wall chitin synthesis" EXACT []
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0032883 ! regulation of chitin biosynthetic process
is_a: GO:0034222 ! regulation of cell wall chitin metabolic process
is_a: GO:0044087 ! regulation of cellular component biogenesis
relationship: regulates GO:0006038 ! cell wall chitin biosynthetic process

[Term]
id: GO:0032885
name: regulation of polysaccharide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." [GOC:mah]
subset: gosubset_prok
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process
relationship: regulates GO:0000271 ! polysaccharide biosynthetic process

[Term]
id: GO:0032886
name: regulation of microtubule-based process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0007017 ! microtubule-based process

[Term]
id: GO:0032887
name: regulation of spindle elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cell cycle process whereby the distance is lengthened between poles of the spindle." [GOC:mah]
is_a: GO:0090224 ! regulation of spindle organization
relationship: regulates GO:0051231 ! spindle elongation

[Term]
id: GO:0032888
name: regulation of mitotic spindle elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cell cycle process whereby the distance is lengthened between poles of the mitotic spindle." [GOC:mah]
is_a: GO:0032887 ! regulation of spindle elongation
is_a: GO:0060236 ! regulation of mitotic spindle organization
relationship: regulates GO:0000022 ! mitotic spindle elongation

[Term]
id: GO:0032889
name: regulation of vacuole fusion, non-autophagic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:mah]
is_a: GO:0044088 ! regulation of vacuole organization
relationship: regulates GO:0042144 ! vacuole fusion, non-autophagic

[Term]
id: GO:0032890
name: regulation of organic acid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0015849 ! organic acid transport

[Term]
id: GO:0032891
name: negative regulation of organic acid transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of organic acids into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of organic acid transport" EXACT []
synonym: "down-regulation of organic acid transport" EXACT []
synonym: "downregulation of organic acid transport" EXACT []
synonym: "inhibition of organic acid transport" NARROW []
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0015849 ! organic acid transport

[Term]
id: GO:0032892
name: positive regulation of organic acid transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "activation of organic acid transport" NARROW []
synonym: "stimulation of organic acid transport" NARROW []
synonym: "up regulation of organic acid transport" EXACT []
synonym: "up-regulation of organic acid transport" EXACT []
synonym: "upregulation of organic acid transport" EXACT []
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0015849 ! organic acid transport

[Term]
id: GO:0032893
name: regulation of gluconate transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of gluconate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0032890 ! regulation of organic acid transport
relationship: regulates GO:0015725 ! gluconate transport

[Term]
id: GO:0032894
name: negative regulation of gluconate transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of gluconate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of gluconate transport" EXACT []
synonym: "down-regulation of gluconate transport" EXACT []
synonym: "downregulation of gluconate transport" EXACT []
synonym: "inhibition of gluconate transport" NARROW []
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0032893 ! regulation of gluconate transport
relationship: negatively_regulates GO:0015725 ! gluconate transport

[Term]
id: GO:0032895
name: positive regulation of gluconate transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of gluconate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "activation of gluconate transport" NARROW []
synonym: "induction of gluconate transport" NARROW []
synonym: "stimulation of gluconate transport" NARROW []
synonym: "up regulation of gluconate transport" EXACT []
synonym: "up-regulation of gluconate transport" EXACT []
synonym: "upregulation of gluconate transport" EXACT []
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0032893 ! regulation of gluconate transport
relationship: positively_regulates GO:0015725 ! gluconate transport

[Term]
id: GO:0032896
name: palmitoyl-CoA 9-desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O." [GOC:kmv]
synonym: "palmitoyl-CoA delta9-desaturase acitivity" EXACT []
is_a: GO:0016215 ! CoA desaturase activity

[Term]
id: GO:0032897
name: negative regulation of viral transcription
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral transcription." [GOC:mah]
synonym: "down regulation of viral transcription" EXACT []
synonym: "down-regulation of viral transcription" EXACT []
synonym: "downregulation of viral transcription" EXACT []
synonym: "inhibition of viral transcription" NARROW []
is_a: GO:0016481 ! negative regulation of transcription
is_a: GO:0046782 ! regulation of viral transcription
is_a: GO:0048524 ! positive regulation of viral reproduction
relationship: negatively_regulates GO:0019083 ! viral transcription

[Term]
id: GO:0032898
name: neurotrophin production
namespace: biological_process
def: "The appearance of a neurotrophin due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. A neurotrophin is any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth." [GOC:ecd, GOC:mah, GOC:mtg_MIT_16mar07]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0043524 ! negative regulation of neuron apoptosis

[Term]
id: GO:0032899
name: regulation of neurotrophin production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of a neurotrophin." [GOC:mah]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0032898 ! neurotrophin production

[Term]
id: GO:0032900
name: negative regulation of neurotrophin production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of a neurotrophin." [GOC:mah]
synonym: "down regulation of neurotrophin production" EXACT []
synonym: "down-regulation of neurotrophin production" EXACT []
synonym: "downregulation of neurotrophin production" EXACT []
synonym: "inhibition of neurotrophin production" NARROW []
is_a: GO:0032899 ! regulation of neurotrophin production
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0032898 ! neurotrophin production

[Term]
id: GO:0032901
name: positive regulation of neurotrophin production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of a neurotrophin." [GOC:mah]
synonym: "activation of neurotrophin production" NARROW []
synonym: "stimulation of neurotrophin production" NARROW []
synonym: "up regulation of neurotrophin production" EXACT []
synonym: "up-regulation of neurotrophin production" EXACT []
synonym: "upregulation of neurotrophin production" EXACT []
is_a: GO:0032899 ! regulation of neurotrophin production
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0032898 ! neurotrophin production

[Term]
id: GO:0032902
name: nerve growth factor production
namespace: biological_process
def: "The appearance of nerve growth factor due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels." [GOC:ecd, GOC:mah]
synonym: "NGF production" EXACT []
is_a: GO:0032898 ! neurotrophin production

[Term]
id: GO:0032903
name: regulation of nerve growth factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of nerve growth factor." [GOC:mah]
synonym: "regulation of NGF production" EXACT []
is_a: GO:0032899 ! regulation of neurotrophin production
relationship: regulates GO:0032902 ! nerve growth factor production

[Term]
id: GO:0032904
name: negative regulation of nerve growth factor production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of nerve growth factor." [GOC:mah]
synonym: "down regulation of nerve growth factor production" EXACT []
synonym: "down-regulation of nerve growth factor production" EXACT []
synonym: "downregulation of nerve growth factor production" EXACT []
synonym: "inhibition of nerve growth factor production" NARROW []
synonym: "negative regulation of NGF production" EXACT []
is_a: GO:0032900 ! negative regulation of neurotrophin production
is_a: GO:0032903 ! regulation of nerve growth factor production
relationship: negatively_regulates GO:0032902 ! nerve growth factor production

[Term]
id: GO:0032905
name: transforming growth factor-beta1 production
namespace: biological_process
def: "The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "TGF-B1 production" EXACT []
synonym: "TGFB1 production" EXACT []
is_a: GO:0071604 ! transforming growth factor-beta production

[Term]
id: GO:0032906
name: transforming growth factor-beta2 production
namespace: biological_process
def: "The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "TGF-B2 production" EXACT []
synonym: "TGFB2 production" EXACT []
is_a: GO:0071604 ! transforming growth factor-beta production

[Term]
id: GO:0032907
name: transforming growth factor-beta3 production
namespace: biological_process
def: "The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "TGF-B3 production" EXACT []
synonym: "TGFB3 production" EXACT []
is_a: GO:0071604 ! transforming growth factor-beta production

[Term]
id: GO:0032908
name: regulation of transforming growth factor-beta1 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah]
synonym: "regulation of TGF-B1 production" EXACT []
synonym: "regulation of TGFB1 production" EXACT []
is_a: GO:0071634 ! regulation of transforming growth factor-beta production
relationship: regulates GO:0032905 ! transforming growth factor-beta1 production

[Term]
id: GO:0032909
name: regulation of transforming growth factor-beta2 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah]
synonym: "regulation of TGF-B2 production" EXACT []
synonym: "regulation of TGFB2 production" EXACT []
is_a: GO:0071634 ! regulation of transforming growth factor-beta production
relationship: regulates GO:0032906 ! transforming growth factor-beta2 production

[Term]
id: GO:0032910
name: regulation of transforming growth factor-beta3 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah]
synonym: "regulation of TGF-B3 production" EXACT []
synonym: "regulation of TGFB3 production" EXACT []
is_a: GO:0071634 ! regulation of transforming growth factor-beta production
relationship: regulates GO:0032907 ! transforming growth factor-beta3 production

[Term]
id: GO:0032911
name: negative regulation of transforming growth factor-beta1 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah]
synonym: "down regulation of transforming growth factor-beta1 production" EXACT []
synonym: "down-regulation of transforming growth factor-beta1 production" EXACT []
synonym: "downregulation of transforming growth factor-beta1 production" EXACT []
synonym: "inhibition of transforming growth factor-beta1 production" NARROW []
synonym: "negative regulation of TGF-B1 production" EXACT []
synonym: "negative regulation of TGFB1 production" EXACT []
is_a: GO:0032908 ! regulation of transforming growth factor-beta1 production
is_a: GO:0071635 ! negative regulation of transforming growth factor-beta production
relationship: negatively_regulates GO:0032905 ! transforming growth factor-beta1 production

[Term]
id: GO:0032912
name: negative regulation of transforming growth factor-beta2 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah]
synonym: "down regulation of transforming growth factor-beta2 production" EXACT []
synonym: "down-regulation of transforming growth factor-beta2 production" EXACT []
synonym: "downregulation of transforming growth factor-beta2 production" EXACT []
synonym: "inhibition of transforming growth factor-beta2 production" NARROW []
synonym: "negative regulation of TGF-B2 production" EXACT []
synonym: "negative regulation of TGFB2 production" EXACT []
is_a: GO:0032909 ! regulation of transforming growth factor-beta2 production
is_a: GO:0071635 ! negative regulation of transforming growth factor-beta production
relationship: negatively_regulates GO:0032906 ! transforming growth factor-beta2 production

[Term]
id: GO:0032913
name: negative regulation of transforming growth factor-beta3 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah]
synonym: "down regulation of transforming growth factor-beta3 production" EXACT []
synonym: "down-regulation of transforming growth factor-beta3 production" EXACT []
synonym: "downregulation of transforming growth factor-beta3 production" EXACT []
synonym: "inhibition of transforming growth factor-beta3 production" NARROW []
synonym: "negative regulation of TGF-B3 production" EXACT []
synonym: "negative regulation of TGFB3 production" EXACT []
is_a: GO:0032910 ! regulation of transforming growth factor-beta3 production
is_a: GO:0071635 ! negative regulation of transforming growth factor-beta production
relationship: negatively_regulates GO:0032907 ! transforming growth factor-beta3 production

[Term]
id: GO:0032914
name: positive regulation of transforming growth factor-beta1 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah]
synonym: "activation of transforming growth factor-beta1 production" NARROW []
synonym: "positive regulation of TGF-B1 production" EXACT []
synonym: "positive regulation of TGFB1 production" EXACT []
synonym: "stimulation of transforming growth factor-beta1 production" NARROW []
synonym: "up regulation of transforming growth factor-beta1 production" EXACT []
synonym: "up-regulation of transforming growth factor-beta1 production" EXACT []
synonym: "upregulation of transforming growth factor-beta1 production" EXACT []
is_a: GO:0032908 ! regulation of transforming growth factor-beta1 production
is_a: GO:0071636 ! positive regulation of transforming growth factor-beta production
relationship: positively_regulates GO:0032905 ! transforming growth factor-beta1 production

[Term]
id: GO:0032915
name: positive regulation of transforming growth factor-beta2 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah]
synonym: "activation of transforming growth factor-beta2 production" NARROW []
synonym: "positive regulation of TGF-B2 production" EXACT []
synonym: "positive regulation of TGFB2 production" EXACT []
synonym: "stimulation of transforming growth factor-beta2 production" NARROW []
synonym: "up regulation of transforming growth factor-beta2 production" EXACT []
synonym: "up-regulation of transforming growth factor-beta2 production" EXACT []
synonym: "upregulation of transforming growth factor-beta2 production" EXACT []
is_a: GO:0032909 ! regulation of transforming growth factor-beta2 production
is_a: GO:0071636 ! positive regulation of transforming growth factor-beta production
relationship: positively_regulates GO:0032906 ! transforming growth factor-beta2 production

[Term]
id: GO:0032916
name: positive regulation of transforming growth factor-beta3 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah]
synonym: "activation of transforming growth factor-beta3 production" NARROW []
synonym: "positive regulation of TGF-B3 production" EXACT []
synonym: "positive regulation of TGFB3 production" EXACT []
synonym: "stimulation of transforming growth factor-beta3 production" NARROW []
synonym: "up regulation of transforming growth factor-beta3 production" EXACT []
synonym: "up-regulation of transforming growth factor-beta3 production" EXACT []
synonym: "upregulation of transforming growth factor-beta3 production" EXACT []
is_a: GO:0032910 ! regulation of transforming growth factor-beta3 production
is_a: GO:0071636 ! positive regulation of transforming growth factor-beta production
relationship: positively_regulates GO:0032907 ! transforming growth factor-beta3 production

[Term]
id: GO:0032917
name: polyamine acetylation
namespace: biological_process
def: "The modification of polyamines by addition of acetyl groups." [GOC:mlg]
is_a: GO:0006595 ! polyamine metabolic process

[Term]
id: GO:0032918
name: spermidine acetylation
namespace: biological_process
def: "The modification of spermidine by addition of acetyl groups." [GOC:mlg]
is_a: GO:0008216 ! spermidine metabolic process
is_a: GO:0032917 ! polyamine acetylation

[Term]
id: GO:0032919
name: spermine acetylation
namespace: biological_process
def: "The modification of spermine by addition of acetyl groups." [GOC:mlg]
is_a: GO:0008215 ! spermine metabolic process
is_a: GO:0032917 ! polyamine acetylation

[Term]
id: GO:0032920
name: putrescine acetylation
namespace: biological_process
def: "The modification of putrescine by addition of acetyl groups." [GOC:mlg]
is_a: GO:0009445 ! putrescine metabolic process
is_a: GO:0032917 ! polyamine acetylation

[Term]
id: GO:0032921
name: sarcosine oxidase complex
namespace: cellular_component
def: "A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity." [GOC:mah, GOC:mlg]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0032922
name: circadian regulation of gene expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah]
synonym: "circadian regulation of protein expression" RELATED []
synonym: "diurnal variation of gene expression" RELATED []
synonym: "diurnal variation of protein expression" RELATED []
is_a: GO:0007623 ! circadian rhythm
is_a: GO:0010468 ! regulation of gene expression

[Term]
id: GO:0032923
name: phosphonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Synthesis of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js]
is_a: GO:0019634 ! phosphonate metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0032924
name: activin receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the activin family binding to a cell surface receptor." [GOC:rl]
synonym: "activin receptor signalling pathway" EXACT []
is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0032925
name: regulation of activin receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:rl]
synonym: "regulation of activin receptor signalling pathway" EXACT []
synonym: "regulation of activin signaling pathway" RELATED []
synonym: "regulation of activin signalling pathway" RELATED []
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: regulates GO:0032924 ! activin receptor signaling pathway

[Term]
id: GO:0032926
name: negative regulation of activin receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:rl]
synonym: "down regulation of activin receptor signaling pathway" EXACT []
synonym: "down-regulation of activin receptor signaling pathway" EXACT []
synonym: "downregulation of activin receptor signaling pathway" EXACT []
synonym: "inhibition of activin receptor signaling pathway" NARROW []
synonym: "negative regulation of activin receptor signalling pathway" EXACT []
synonym: "negative regulation of activin signaling pathway" RELATED []
synonym: "negative regulation of activin signalling pathway" RELATED []
is_a: GO:0032925 ! regulation of activin receptor signaling pathway
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: negatively_regulates GO:0032924 ! activin receptor signaling pathway

[Term]
id: GO:0032927
name: positive regulation of activin receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:rl]
synonym: "activation of activin receptor signaling pathway" NARROW []
synonym: "positive regulation of activin receptor signalling pathway" EXACT []
synonym: "positive regulation of activin signaling pathway" RELATED []
synonym: "positive regulation of activin signalling pathway" RELATED []
synonym: "stimulation of activin receptor signaling pathway" NARROW []
synonym: "up regulation of activin receptor signaling pathway" EXACT []
synonym: "up-regulation of activin receptor signaling pathway" EXACT []
synonym: "upregulation of activin receptor signaling pathway" EXACT []
is_a: GO:0032925 ! regulation of activin receptor signaling pathway
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: positively_regulates GO:0032924 ! activin receptor signaling pathway

[Term]
id: GO:0032928
name: regulation of superoxide release
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah]
is_a: GO:0080010 ! regulation of oxygen and reactive oxygen species metabolic process
relationship: regulates GO:0042554 ! superoxide anion generation

[Term]
id: GO:0032929
name: negative regulation of superoxide release
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah]
synonym: "down regulation of superoxide release" EXACT []
synonym: "down-regulation of superoxide release" EXACT []
synonym: "downregulation of superoxide release" EXACT []
synonym: "inhibition of superoxide release" NARROW []
is_a: GO:0010671 ! negative regulation of oxygen and reactive oxygen species metabolic process
is_a: GO:0032928 ! regulation of superoxide release
relationship: negatively_regulates GO:0042554 ! superoxide anion generation

[Term]
id: GO:0032930
name: positive regulation of superoxide release
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah]
synonym: "activation of superoxide release" NARROW []
synonym: "stimulation of superoxide release" NARROW []
synonym: "up regulation of superoxide release" EXACT []
synonym: "up-regulation of superoxide release" EXACT []
synonym: "upregulation of superoxide release" EXACT []
is_a: GO:0010670 ! positive regulation of oxygen and reactive oxygen species metabolic process
is_a: GO:0032928 ! regulation of superoxide release
relationship: positively_regulates GO:0042554 ! superoxide anion generation

[Term]
id: GO:0032931
name: histone acetyltransferase activity (H3-K56 specific)
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group onto lysine at position 56 of the histone H3 protein." [GOC:mah]
synonym: "histone lysine N-acetyltransferase activity (H3-K56 specific)" EXACT []
is_a: GO:0010484 ! H3 histone acetyltransferase activity

[Term]
id: GO:0032932
name: negative regulation of spindle astral microtubule depolymerization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the depolymerization of astral microtubules." [GOC:mah]
synonym: "astral microtubule stabilization" EXACT []
is_a: GO:0007026 ! negative regulation of microtubule depolymerization
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0090224 ! regulation of spindle organization
relationship: negatively_regulates GO:0060172 ! spindle astral microtubule depolymerization

[Term]
id: GO:0032933
name: SREBP-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of altered levels of one or more lipids, and resulting in the activation of transcription by SREBP." [GOC:mah, PMID:12923525]
synonym: "SREBP-mediated signalling pathway" EXACT []
is_a: GO:0006984 ! ER-nuclear signaling pathway

[Term]
id: GO:0032934
name: sterol binding
namespace: molecular_function
alt_id: GO:0005498
def: "Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [ChEBI:15889, GOC:mah]
subset: gosubset_prok
synonym: "sterol carrier activity" RELATED [GOC:mah]
is_a: GO:0005496 ! steroid binding

[Term]
id: GO:0032935
name: sterol sensor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of a sterol." [GOC:mah]
synonym: "sterol-sensing domain" NARROW []
is_a: GO:0032934 ! sterol binding

[Term]
id: GO:0032936
name: SREBP-SCAP complex
namespace: cellular_component
def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed." [PMID:12923525]
synonym: "Sre1-Scp1 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0032937
name: SREBP-SCAP-Insig complex
namespace: cellular_component
def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) the ER membrane." [PMID:12923525]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0030176 ! integral to endoplasmic reticulum membrane

[Term]
id: GO:0032938
name: negative regulation of translation in response to oxidative stress
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
is_a: GO:0032055 ! negative regulation of translation in response to stress
is_a: GO:0043556 ! regulation of translation in response to oxidative stress

[Term]
id: GO:0032939
name: positive regulation of translation in response to oxidative stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
synonym: "activation of translation in response to oxidative stress" NARROW []
synonym: "stimulation of translation in response to oxidative stress" NARROW []
synonym: "up regulation of translation in response to oxidative stress" EXACT []
synonym: "up-regulation of translation in response to oxidative stress" EXACT []
synonym: "upregulation of translation in response to oxidative stress" EXACT []
is_a: GO:0032056 ! positive regulation of translation in response to stress
is_a: GO:0043556 ! regulation of translation in response to oxidative stress

[Term]
id: GO:0032940
name: secretion by cell
namespace: biological_process
def: "The controlled release of a substance by a cell." [GOC:mah]
synonym: "cellular secretion" EXACT []
xref: Wikipedia:Secretion
is_a: GO:0009987 ! cellular process
is_a: GO:0046903 ! secretion
is_a: GO:0051649 ! establishment of localization in cell

[Term]
id: GO:0032941
name: secretion by tissue
namespace: biological_process
def: "The controlled release of a substance by a tissue." [GOC:mah]
synonym: "expulsion of gland contents" RELATED [GOC:mah]
synonym: "tissue secretion" EXACT []
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0046903 ! secretion

[Term]
id: GO:0032942
name: inositol tetrakisphosphate 2-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP." [GOC:hf]
synonym: "1D-myo-inositol-tetrakisphosphate 2-kinase activity" EXACT []
synonym: "inositol 1,3,4,6-tetrakisphosphate 2-kinase activity" EXACT []
synonym: "inositol-tetrakisphosphate 2-kinase activity" EXACT []
xref: EC:2.7.1.-
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0032943
name: mononuclear cell proliferation
namespace: biological_process
def: "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form." [GOC:add]
synonym: "PBMC proliferation" NARROW []
synonym: "peripheral blood mononuclear cell proliferation" NARROW []
is_a: GO:0070661 ! leukocyte proliferation

[Term]
id: GO:0032944
name: regulation of mononuclear cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation." [GOC:add]
synonym: "regulation of PBMC proliferation" NARROW []
synonym: "regulation of peripheral blood mononuclear cell proliferation" NARROW []
is_a: GO:0070663 ! regulation of leukocyte proliferation
relationship: regulates GO:0032943 ! mononuclear cell proliferation

[Term]
id: GO:0032945
name: negative regulation of mononuclear cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mononuclear cell proliferation." [GOC:add]
synonym: "negative regulation of PBMC proliferation" NARROW []
synonym: "negative regulation of peripheral blood mononuclear cell proliferation" NARROW []
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0070664 ! negative regulation of leukocyte proliferation
relationship: negatively_regulates GO:0032943 ! mononuclear cell proliferation

[Term]
id: GO:0032946
name: positive regulation of mononuclear cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation." [GOC:add]
synonym: "activation of mononuclear cell proliferation" NARROW []
synonym: "positive regulation of PBMC proliferation" NARROW []
synonym: "positive regulation of peripheral blood mononuclear cell proliferation" NARROW []
synonym: "stimulation of mononuclear cell proliferation" NARROW []
synonym: "up regulation of mononuclear cell proliferation" EXACT []
synonym: "up-regulation of mononuclear cell proliferation" EXACT []
synonym: "upregulation of mononuclear cell proliferation" EXACT []
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0070665 ! positive regulation of leukocyte proliferation
relationship: positively_regulates GO:0032943 ! mononuclear cell proliferation

[Term]
id: GO:0032947
name: protein complex scaffold
namespace: molecular_function
def: "Functions to provide a physical support for the assembly of a multiprotein complex." [GOC:mah]
is_a: GO:0005198 ! structural molecule activity
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0032948
name: regulation of alpha-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-glucans." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of alpha-glucan metabolism" EXACT []
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
relationship: regulates GO:0030978 ! alpha-glucan metabolic process

[Term]
id: GO:0032949
name: regulation of alpha-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of alpha-glucans." [GOC:mah]
synonym: "regulation of alpha-glucan anabolism" EXACT []
synonym: "regulation of alpha-glucan biosynthesis" EXACT []
synonym: "regulation of alpha-glucan formation" EXACT []
synonym: "regulation of alpha-glucan synthesis" EXACT []
is_a: GO:0010962 ! regulation of glucan biosynthetic process
is_a: GO:0032948 ! regulation of alpha-glucan metabolic process
relationship: regulates GO:0030979 ! alpha-glucan biosynthetic process

[Term]
id: GO:0032950
name: regulation of beta-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving beta-glucans." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of beta-glucan metabolism" EXACT []
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
relationship: regulates GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0032951
name: regulation of beta-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of beta-glucans." [GOC:mah]
synonym: "regulation of beta-glucan anabolism" EXACT []
synonym: "regulation of beta-glucan biosynthesis" EXACT []
synonym: "regulation of beta-glucan formation" EXACT []
synonym: "regulation of beta-glucan synthesis" EXACT []
is_a: GO:0010962 ! regulation of glucan biosynthetic process
is_a: GO:0032950 ! regulation of beta-glucan metabolic process
relationship: regulates GO:0051274 ! beta-glucan biosynthetic process

[Term]
id: GO:0032952
name: regulation of 1,3-beta-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving beta-1,3 glucans." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of 1,3-beta-glucan metabolism" EXACT []
is_a: GO:0032950 ! regulation of beta-glucan metabolic process
relationship: regulates GO:0006074 ! 1,3-beta-glucan metabolic process

[Term]
id: GO:0032953
name: regulation of 1,3-beta-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta-1,3 glucans." [GOC:mah]
synonym: "regulation of 1,3-beta-glucan anabolism" EXACT []
synonym: "regulation of 1,3-beta-glucan biosynthesis" EXACT []
synonym: "regulation of 1,3-beta-glucan formation" EXACT []
synonym: "regulation of 1,3-beta-glucan synthesis" EXACT []
is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process
is_a: GO:0032952 ! regulation of 1,3-beta-glucan metabolic process
relationship: regulates GO:0006075 ! 1,3-beta-glucan biosynthetic process

[Term]
id: GO:0032954
name: regulation of cytokinetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a cytokinetic process." [GOC:mah]
subset: gosubset_prok
is_a: GO:0032465 ! regulation of cytokinesis
relationship: regulates GO:0032506 ! cytokinetic process

[Term]
id: GO:0032955
name: regulation of barrier septum formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of barrier septum formation. Barrier septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mah]
is_a: GO:0032954 ! regulation of cytokinetic process
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0000917 ! barrier septum formation

[Term]
id: GO:0032956
name: regulation of actin cytoskeleton organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah]
synonym: "regulation of actin cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0032970 ! regulation of actin filament-based process
is_a: GO:0051493 ! regulation of cytoskeleton organization
relationship: regulates GO:0030036 ! actin cytoskeleton organization

[Term]
id: GO:0032957
name: inositol trisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [ChEBI:24540, ChEBI:24848, GOC:mah]
synonym: "inositol trisphosphate metabolism" EXACT []
synonym: "IP3 metabolic process" EXACT []
synonym: "IP3 metabolism" EXACT []
synonym: "myo-inositol trisphosphate metabolic process" NARROW []
is_a: GO:0043647 ! inositol phosphate metabolic process

[Term]
id: GO:0032958
name: inositol phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [ChEBI:24848, ChEBI:25448, GOC:mah]
comment: See also the biological process term 'inositol and derivative phosphorylation ; GO:0046853'.
synonym: "inositol phosphate anabolism" EXACT []
synonym: "inositol phosphate biosynthesis" EXACT []
synonym: "inositol phosphate formation" EXACT []
synonym: "inositol phosphate synthesis" EXACT []
synonym: "myo-inositol phosphate biosynthetic process" NARROW []
is_a: GO:0006021 ! inositol biosynthetic process
is_a: GO:0043647 ! inositol phosphate metabolic process

[Term]
id: GO:0032959
name: inositol trisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [ChEBI:24848, ChEBI:25450, GOC:mah]
synonym: "inositol trisphosphate anabolism" EXACT []
synonym: "inositol trisphosphate biosynthesis" EXACT []
synonym: "inositol trisphosphate formation" EXACT []
synonym: "inositol trisphosphate synthesis" EXACT []
synonym: "IP3 biosynthesis" EXACT []
synonym: "IP3 biosynthetic process" EXACT []
synonym: "myo-inositol trisphosphate biosynthetic process" NARROW []
is_a: GO:0032957 ! inositol trisphosphate metabolic process
is_a: GO:0032958 ! inositol phosphate biosynthetic process

[Term]
id: GO:0032960
name: regulation of inositol trisphosphate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah]
synonym: "regulation of inositol trisphosphate anabolism" EXACT []
synonym: "regulation of inositol trisphosphate biosynthesis" EXACT []
synonym: "regulation of inositol trisphosphate formation" EXACT []
synonym: "regulation of inositol trisphosphate synthesis" EXACT []
synonym: "regulation of IP3 biosynthesis" EXACT []
synonym: "regulation of IP3 biosynthetic process" EXACT []
synonym: "regulation of myo-inositol trisphosphate biosynthesis" NARROW []
synonym: "regulation of myo-inositol trisphosphate biosynthetic process" NARROW []
is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process
relationship: regulates GO:0032959 ! inositol trisphosphate biosynthetic process

[Term]
id: GO:0032961
name: negative regulation of inositol trisphosphate biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah]
synonym: "negative regulation of inositol trisphosphate anabolism" EXACT []
synonym: "negative regulation of inositol trisphosphate biosynthesis" EXACT []
synonym: "negative regulation of inositol trisphosphate formation" EXACT []
synonym: "negative regulation of inositol trisphosphate synthesis" EXACT []
synonym: "negative regulation of IP3 biosynthesis" EXACT []
synonym: "negative regulation of IP3 biosynthetic process" EXACT []
synonym: "negative regulation of myo-inositol trisphosphate biosynthesis" NARROW []
synonym: "negative regulation of myo-inositol trisphosphate biosynthetic process" NARROW []
is_a: GO:0010920 ! negative regulation of inositol phosphate biosynthetic process
is_a: GO:0032960 ! regulation of inositol trisphosphate biosynthetic process
relationship: negatively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process

[Term]
id: GO:0032962
name: positive regulation of inositol trisphosphate biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah]
synonym: "positive regulation of inositol trisphosphate anabolism" EXACT []
synonym: "positive regulation of inositol trisphosphate biosynthesis" EXACT []
synonym: "positive regulation of inositol trisphosphate formation" EXACT []
synonym: "positive regulation of inositol trisphosphate synthesis" EXACT []
synonym: "positive regulation of IP3 biosynthesis" EXACT []
synonym: "positive regulation of IP3 biosynthetic process" EXACT []
synonym: "positive regulation of myo-inositol trisphosphate biosynthesis" NARROW []
synonym: "positive regulation of myo-inositol trisphosphate biosynthetic process" NARROW []
is_a: GO:0032960 ! regulation of inositol trisphosphate biosynthetic process
is_a: GO:0060732 ! positive regulation of inositol phosphate biosynthetic process
relationship: positively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process

[Term]
id: GO:0032963
name: collagen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "collagen metabolism" EXACT []
is_a: GO:0044259 ! multicellular organismal macromolecule metabolic process

[Term]
id: GO:0032964
name: collagen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "collagen anabolism" EXACT []
synonym: "collagen biosynthesis" EXACT []
synonym: "collagen formation" EXACT []
synonym: "collagen synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0032963 ! collagen metabolic process

[Term]
id: GO:0032965
name: regulation of collagen biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah]
synonym: "regulation of collagen anabolism" EXACT []
synonym: "regulation of collagen biosynthesis" EXACT []
synonym: "regulation of collagen formation" EXACT []
synonym: "regulation of collagen synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0010712 ! regulation of collagen metabolic process
relationship: regulates GO:0032964 ! collagen biosynthetic process

[Term]
id: GO:0032966
name: negative regulation of collagen biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah]
synonym: "negative regulation of collagen anabolism" EXACT []
synonym: "negative regulation of collagen biosynthesis" EXACT []
synonym: "negative regulation of collagen formation" EXACT []
synonym: "negative regulation of collagen synthesis" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0010713 ! negative regulation of collagen metabolic process
is_a: GO:0032965 ! regulation of collagen biosynthetic process
relationship: negatively_regulates GO:0032964 ! collagen biosynthetic process

[Term]
id: GO:0032967
name: positive regulation of collagen biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah]
synonym: "positive regulation of collagen anabolism" EXACT []
synonym: "positive regulation of collagen biosynthesis" EXACT []
synonym: "positive regulation of collagen formation" EXACT []
synonym: "positive regulation of collagen synthesis" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0010714 ! positive regulation of collagen metabolic process
is_a: GO:0032965 ! regulation of collagen biosynthetic process
relationship: positively_regulates GO:0032964 ! collagen biosynthetic process

[Term]
id: GO:0032968
name: positive regulation of RNA elongation from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah]
synonym: "positive regulation of transcription elongation from RNA polymerase II promoter" BROAD []
is_a: GO:0032786 ! positive regulation of RNA elongation
is_a: GO:0034243 ! regulation of RNA elongation from RNA polymerase II promoter
relationship: positively_regulates GO:0006368 ! RNA elongation from RNA polymerase II promoter

[Term]
id: GO:0032969
name: endosomal scaffold complex
namespace: cellular_component
def: "A complex in eukaryotic cells containing Mapbpip (p14,Rab25) and Map2k1ip1 (MP1). The complex anchors on late endosomes and is involved in activating ERK 1/2, key components in MAPK signaling." [PMID:15263099]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0031902 ! late endosome membrane

[Term]
id: GO:0032970
name: regulation of actin filament-based process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0030029 ! actin filament-based process

[Term]
id: GO:0032971
name: regulation of muscle filament sliding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle filament sliding." [GOC:ecd]
is_a: GO:0006937 ! regulation of muscle contraction
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0032970 ! regulation of actin filament-based process
relationship: regulates GO:0030049 ! muscle filament sliding

[Term]
id: GO:0032972
name: regulation of muscle filament sliding speed
namespace: biological_process
def: "Any process that modulates the velocity of muscle filament sliding." [GOC:dph, GOC:ecd, GOC:tb]
is_a: GO:0032971 ! regulation of muscle filament sliding
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0032973
name: amino acid export
namespace: biological_process
def: "The directed movement of amino acids out of a cell or organelle." [GOC:mah]
synonym: "amino acid efflux" EXACT []
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0032974
name: amino acid export from vacuole
namespace: biological_process
def: "The directed movement of amino acids out of the vacuole." [GOC:mah]
synonym: "amino acid efflux from vacuole" EXACT []
synonym: "vacuolar amino acid export" EXACT []
is_a: GO:0032973 ! amino acid export
is_a: GO:0034487 ! vacuolar amino acid transport

[Term]
id: GO:0032975
name: amino acid import into vacuole
namespace: biological_process
def: "The directed movement of amino acids into the vacuole." [GOC:mah]
synonym: "vacuolar amino acid import" EXACT []
is_a: GO:0034487 ! vacuolar amino acid transport
is_a: GO:0043090 ! amino acid import

[Term]
id: GO:0032976
name: release of matrix enzymes from mitochondria
namespace: biological_process
def: "The process by which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol." [GOC:mah, PMID:9843949]
synonym: "mAST release from mitochondria" NARROW []
synonym: "release of aspartate aminotransferase from mitochondria" NARROW []
is_a: GO:0008637 ! apoptotic mitochondrial changes

[Term]
id: GO:0032977
name: membrane insertase activity
namespace: molecular_function
def: "Mediates the integration of proteins into a membrane from the inner side of the membrane. Membrane insertases are highly conserved and include the bacterial YidC family, the plant chloroplast Alb3 family, and the fungal and animal mitochondrial Oxa1/Cox18 family." [PMID:14739936]
subset: gosubset_prok
is_a: GO:0008565 ! protein transporter activity

[Term]
id: GO:0032978
name: protein insertion into membrane from inner side
namespace: biological_process
def: "The process by which a protein is incorporated into a lipid bilayer, e.g., the prokaryotic, mitochondrial, or chloroplast inner membrane, from the inner side." [PMID:14739936, PMID:15473843]
synonym: "insertion of proteins into membrane from the inner side" EXACT []
is_a: GO:0051205 ! protein insertion into membrane

[Term]
id: GO:0032979
name: protein insertion into mitochondrial membrane from inner side
namespace: biological_process
def: "The process by which a protein is incorporated into the mitochondrial membrane from the inner side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix." [PMID:12880202, PMID:15473843]
synonym: "insertion of proteins into the mitochondrial membrane from the inner side" EXACT []
is_a: GO:0032978 ! protein insertion into membrane from inner side
is_a: GO:0051204 ! protein insertion into mitochondrial membrane

[Term]
id: GO:0032980
name: keratinocyte activation
namespace: biological_process
def: "A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines." [GOC:mah, PMID:15737202]
is_a: GO:0001775 ! cell activation
relationship: part_of GO:0048699 ! generation of neurons

[Term]
id: GO:0032981
name: mitochondrial respiratory chain complex I assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph]
synonym: "mitochondrial complex I assembly" EXACT []
synonym: "mitochondrial NADH dehydrogenase complex (ubiquinone) assembly" EXACT []
is_a: GO:0010257 ! NADH dehydrogenase complex assembly
is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly

[Term]
id: GO:0032982
name: myosin filament
namespace: cellular_component
def: "A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament." [GOC:mah]
synonym: "myosin thick filament" RELATED []
synonym: "thick filament" RELATED []
is_a: GO:0016459 ! myosin complex

[Term]
id: GO:0032983
name: kainate selective glutamate receptor complex
namespace: cellular_component
def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluR5-7 and KA-1/2 subunits." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]
is_a: GO:0008328 ! ionotropic glutamate receptor complex

[Term]
id: GO:0032984
name: macromolecular complex disassembly
namespace: biological_process
def: "The disaggregation of a macromolecular complex into its constituent components." [GOC:mah]
subset: gosubset_prok
synonym: "macromolecule complex disassembly" EXACT []
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0043933 ! macromolecular complex subunit organization

[Term]
id: GO:0032985
name: protein-carbohydrate complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-carbohydrate complex into its constituent components." [GOC:mah]
is_a: GO:0032984 ! macromolecular complex disassembly

[Term]
id: GO:0032986
name: protein-DNA complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-DNA complex into its constituent components." [GOC:mah]
synonym: "DNA-protein complex disassembly" EXACT [GOC:mah]
is_a: GO:0034623 ! cellular macromolecular complex disassembly

[Term]
id: GO:0032987
name: protein-lipid complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-lipid complex into its constituent components." [GOC:mah]
is_a: GO:0032984 ! macromolecular complex disassembly

[Term]
id: GO:0032988
name: ribonucleoprotein complex disassembly
namespace: biological_process
def: "The disaggregation of a protein-RNA complex into its constituent components." [GOC:mah]
synonym: "protein-RNA complex disassembly" EXACT []
synonym: "RNA-protein complex disassembly" EXACT []
synonym: "RNP complex disassembly" EXACT []
is_a: GO:0034623 ! cellular macromolecular complex disassembly

[Term]
id: GO:0032989
name: cellular component morphogenesis
namespace: biological_process
def: "The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:mah, GOC:tb]
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "cellular structure morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
is_a: GO:0016043 ! cellular component organization
is_a: GO:0048869 ! cellular developmental process

[Term]
id: GO:0032990
name: cell part morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a cell part are generated and organized. Morphogenesis pertains to the creation of form." [GOC:mah]
is_a: GO:0032989 ! cellular component morphogenesis

[Term]
id: GO:0032991
name: macromolecular complex
namespace: cellular_component
def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "macromolecule complex" EXACT []
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0032992
name: protein-carbohydrate complex
namespace: cellular_component
def: "A macromolecular complex containing both protein and carbohydrate molecules." [GOC:mah]
subset: gosubset_prok
is_a: GO:0032991 ! macromolecular complex

[Term]
id: GO:0032993
name: protein-DNA complex
namespace: cellular_component
def: "A macromolecular complex containing both protein and DNA molecules." [GOC:mah]
subset: gosubset_prok
synonym: "DNA-protein complex" EXACT [GOC:mah]
is_a: GO:0032991 ! macromolecular complex

[Term]
id: GO:0032994
name: protein-lipid complex
namespace: cellular_component
def: "A macromolecular complex containing both protein and lipid molecules." [GOC:mah]
subset: gosubset_prok
is_a: GO:0032991 ! macromolecular complex

[Term]
id: GO:0032995
name: regulation of fungal-type cell wall biogenesis
namespace: biological_process
def: "Any process that modulates the process by which a cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of chitin- and beta-glucan-containing cell wall biogenesis" RELATED [GOC:mah]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0009272 ! fungal-type cell wall biogenesis

[Term]
id: GO:0032996
name: Bcl3-Bcl10 complex
namespace: cellular_component
def: "A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus." [PMID:16280327]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0032997
name: Fc receptor complex
namespace: cellular_component
def: "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
subset: goslim_pir
synonym: "Fc-receptor complex" EXACT []
synonym: "FcR complex" EXACT []
synonym: "immunoglobulin receptor complex" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0032998
name: Fc-epsilon receptor I complex
namespace: cellular_component
def: "A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "FceRI complex" EXACT []
synonym: "IgE receptor complex" BROAD []
synonym: "immunoglobulin E receptor complex" BROAD []
is_a: GO:0032997 ! Fc receptor complex

[Term]
id: GO:0032999
name: Fc-alpha receptor I complex
namespace: cellular_component
def: "A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12524384]
synonym: "FcaRI complex" EXACT []
synonym: "IgA receptor complex" BROAD []
synonym: "immunoglobulin A receptor complex" BROAD []
is_a: GO:0032997 ! Fc receptor complex

[Term]
id: GO:0033000
name: Fc-gamma receptor I complex
namespace: cellular_component
def: "A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11244038, PMID:12413532]
synonym: "FcgRI complex" EXACT []
synonym: "IgG receptor complex" BROAD []
synonym: "immunoglobulin G receptor complex" BROAD []
is_a: GO:0032997 ! Fc receptor complex

[Term]
id: GO:0033001
name: Fc-gamma receptor III complex
namespace: cellular_component
def: "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11244038, PMID:12413532]
synonym: "FcgRIII complex" EXACT []
synonym: "IgG receptor complex" BROAD []
synonym: "immunoglobulin G receptor complex" BROAD []
is_a: GO:0032997 ! Fc receptor complex

[Term]
id: GO:0033002
name: muscle cell proliferation
namespace: biological_process
def: "The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah]
synonym: "myocyte proliferation" EXACT []
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0033003
name: regulation of mast cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell activation." [GOC:mah]
is_a: GO:0002694 ! regulation of leukocyte activation
relationship: regulates GO:0045576 ! mast cell activation

[Term]
id: GO:0033004
name: negative regulation of mast cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate, or extent of mast cell activation." [GOC:mah]
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0033003 ! regulation of mast cell activation
relationship: negatively_regulates GO:0045576 ! mast cell activation

[Term]
id: GO:0033005
name: positive regulation of mast cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation." [GOC:mah]
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0033003 ! regulation of mast cell activation
relationship: positively_regulates GO:0045576 ! mast cell activation

[Term]
id: GO:0033006
name: regulation of mast cell activation during immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell activation during an immune response." [GOC:mah]
is_a: GO:0033003 ! regulation of mast cell activation
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0002279 ! mast cell activation during immune response

[Term]
id: GO:0033007
name: negative regulation of mast cell activation during immune response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate, or extent of mast cell activation during an immune response." [GOC:mah]
is_a: GO:0033004 ! negative regulation of mast cell activation
is_a: GO:0033006 ! regulation of mast cell activation during immune response
relationship: negatively_regulates GO:0002279 ! mast cell activation during immune response

[Term]
id: GO:0033008
name: positive regulation of mast cell activation during immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation during an immune response." [GOC:mah]
is_a: GO:0033005 ! positive regulation of mast cell activation
is_a: GO:0033006 ! regulation of mast cell activation during immune response
relationship: positively_regulates GO:0002279 ! mast cell activation during immune response

[Term]
id: GO:0033009
name: nucleomorph
namespace: cellular_component
def: "A small, vestigial nucleus found in some plastids that derive from a eukaryotic endosymbiont. Observed in chlorarachniophytes and cryptomonads, which acquired their plastids from a green and red alga respectively." [PMID:16760254]
xref: Wikipedia:Nucleomorph
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0033010
name: paranodal junction
namespace: cellular_component
def: "A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath." [PMID:11395001, PMID:14630217]
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0033011
name: perinuclear theca
namespace: cellular_component
def: "A condensed cytoplasmic structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer and, continuing caudally beyond the acrosomic system, the postacrosomal sheath. The perinuclear theca has been considered a cytoskeletal scaffold responsible for maintaining the overall architecture of the mature sperm head; however, recent studies indicate that the bulk of its constituent proteins are not traditional cytoskeletal proteins but rather a variety of cytosolic proteins." [PMID:17289678, PMID:8025156]
is_a: GO:0005856 ! cytoskeleton
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0048471 ! perinuclear region of cytoplasm

[Term]
id: GO:0033012
name: porosome
namespace: cellular_component
def: "A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles." [PMID:15090256, PMID:16563225]
xref: Wikipedia:Porosome
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0033013
name: tetrapyrrole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [ChEBI:26932, GOC:mah]
synonym: "tetrapyrrole metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0033014
name: tetrapyrrole biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [ChEBI:26932, GOC:mah]
synonym: "tetrapyrrole anabolism" EXACT []
synonym: "tetrapyrrole biosynthesis" EXACT []
synonym: "tetrapyrrole formation" EXACT []
synonym: "tetrapyrrole synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0033013 ! tetrapyrrole metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process

[Term]
id: GO:0033015
name: tetrapyrrole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [ChEBI:26932, GOC:mah]
synonym: "tetrapyrrole breakdown" EXACT []
synonym: "tetrapyrrole catabolism" EXACT []
synonym: "tetrapyrrole degradation" EXACT []
is_a: GO:0033013 ! tetrapyrrole metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0033016
name: rhoptry membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a rhoptry." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
relationship: part_of GO:0020008 ! rhoptry

[Term]
id: GO:0033017
name: sarcoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the sarcoplasmic reticulum." [GOC:rph]
is_a: GO:0005789 ! endoplasmic reticulum membrane
relationship: part_of GO:0016529 ! sarcoplasmic reticulum

[Term]
id: GO:0033018
name: sarcoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the sarcoplasmic reticulum." [GOC:rph]
is_a: GO:0005788 ! endoplasmic reticulum lumen
relationship: part_of GO:0016529 ! sarcoplasmic reticulum

[Term]
id: GO:0033019
name: 5-hydroxyvalerate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH." [GOC:mlg, PMID:12406764]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033020
name: cyclopentanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyclopentanol." [GOC:mlg, PMID:12406764]
subset: gosubset_prok
synonym: "cyclopentanol metabolism" EXACT []
is_a: GO:0034308 ! monohydric alcohol metabolic process

[Term]
id: GO:0033021
name: cyclopentanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyclopentanol." [GOC:mah, PMID:12406764]
subset: gosubset_prok
synonym: "cyclopentanol anabolism" EXACT []
synonym: "cyclopentanol biosynthesis" EXACT []
synonym: "cyclopentanol formation" EXACT []
synonym: "cyclopentanol synthesis" EXACT []
is_a: GO:0033020 ! cyclopentanol metabolic process
is_a: GO:0034309 ! monohydric alcohol biosynthetic process

[Term]
id: GO:0033022
name: cyclopentanol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyclopentanol." [GOC:mah, PMID:12406764]
subset: gosubset_prok
synonym: "cyclopentanol breakdown" EXACT []
synonym: "cyclopentanol catabolism" EXACT []
synonym: "cyclopentanol degradation" EXACT []
is_a: GO:0033020 ! cyclopentanol metabolic process
is_a: GO:0034310 ! monohydric alcohol catabolic process

[Term]
id: GO:0033023
name: mast cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:11292031]
comment: Note that this term represents the return of mast cell levels to stable numbers following an immune response as well as the proliferation and elimination of mast cells required to maintain stable numbers in the absence of an outside stimulus.
is_a: GO:0002262 ! myeloid cell homeostasis

[Term]
id: GO:0033024
name: mast cell apoptosis
namespace: biological_process
def: "The process of apoptosis in mast cells." [GOC:add, PMID:11292031, PMID:12360215, PMID:16605130]
synonym: "apoptosis of mast cells" EXACT []
is_a: GO:0033028 ! myeloid cell apoptosis
relationship: part_of GO:0033023 ! mast cell homeostasis

[Term]
id: GO:0033025
name: regulation of mast cell apoptosis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell apoptosis." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0033032 ! regulation of myeloid cell apoptosis
relationship: regulates GO:0033024 ! mast cell apoptosis

[Term]
id: GO:0033026
name: negative regulation of mast cell apoptosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a mast cell apoptosis." [GOC:add]
synonym: "down regulation of mast cell apoptosis" EXACT []
synonym: "down-regulation of mast cell apoptosis" EXACT []
synonym: "downregulation of mast cell apoptosis" EXACT []
synonym: "inhibition of mast cell apoptosis" NARROW []
is_a: GO:0033025 ! regulation of mast cell apoptosis
is_a: GO:0033033 ! negative regulation of myeloid cell apoptosis
relationship: negatively_regulates GO:0033024 ! mast cell apoptosis

[Term]
id: GO:0033027
name: positive regulation of mast cell apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of mast cell apoptosis." [GOC:add]
synonym: "activation of mast cell apoptosis" NARROW []
synonym: "stimulation of mast cell apoptosis" NARROW []
synonym: "up regulation of mast cell apoptosis" EXACT []
synonym: "up-regulation of mast cell apoptosis" EXACT []
synonym: "upregulation of mast cell apoptosis" EXACT []
is_a: GO:0033025 ! regulation of mast cell apoptosis
is_a: GO:0033034 ! positive regulation of myeloid cell apoptosis
relationship: positively_regulates GO:0033024 ! mast cell apoptosis

[Term]
id: GO:0033028
name: myeloid cell apoptosis
namespace: biological_process
def: "The process of apoptosis in myeloid cells." [GOC:add, PMID:11292031, PMID:15330259, PMID:17133093]
synonym: "apoptosis of myeloid cells" EXACT []
is_a: GO:0006915 ! apoptosis

[Term]
id: GO:0033029
name: regulation of neutrophil apoptosis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of neutrophil apoptosis." [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0033032 ! regulation of myeloid cell apoptosis
relationship: regulates GO:0001781 ! neutrophil apoptosis

[Term]
id: GO:0033030
name: negative regulation of neutrophil apoptosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a neutrophil apoptosis." [GOC:add]
synonym: "down regulation of neutrophil apoptosis" EXACT []
synonym: "down-regulation of neutrophil apoptosis" EXACT []
synonym: "downregulation of neutrophil apoptosis" EXACT []
synonym: "inhibition of neutrophil apoptosis" NARROW []
is_a: GO:0033029 ! regulation of neutrophil apoptosis
is_a: GO:0033033 ! negative regulation of myeloid cell apoptosis
relationship: negatively_regulates GO:0001781 ! neutrophil apoptosis

[Term]
id: GO:0033031
name: positive regulation of neutrophil apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of neutrophil apoptosis." [GOC:add]
synonym: "activation of neutrophil apoptosis" NARROW []
synonym: "stimulation of neutrophil apoptosis" NARROW []
synonym: "up regulation of neutrophil apoptosis" EXACT []
synonym: "up-regulation of neutrophil apoptosis" EXACT []
synonym: "upregulation of neutrophil apoptosis" EXACT []
is_a: GO:0033029 ! regulation of neutrophil apoptosis
is_a: GO:0033034 ! positive regulation of myeloid cell apoptosis
relationship: positively_regulates GO:0001781 ! neutrophil apoptosis

[Term]
id: GO:0033032
name: regulation of myeloid cell apoptosis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of myeloid cell apoptosis." [GOC:add]
is_a: GO:0042981 ! regulation of apoptosis
relationship: regulates GO:0033028 ! myeloid cell apoptosis

[Term]
id: GO:0033033
name: negative regulation of myeloid cell apoptosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptosis." [GOC:add]
synonym: "down regulation of myeloid cell apoptosis" EXACT []
synonym: "down-regulation of myeloid cell apoptosis" EXACT []
synonym: "downregulation of myeloid cell apoptosis" EXACT []
synonym: "inhibition of myeloid cell apoptosis" NARROW []
is_a: GO:0033032 ! regulation of myeloid cell apoptosis
is_a: GO:0043066 ! negative regulation of apoptosis
relationship: negatively_regulates GO:0033028 ! myeloid cell apoptosis

[Term]
id: GO:0033034
name: positive regulation of myeloid cell apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptosis." [GOC:add]
synonym: "activation of myeloid cell apoptosis" NARROW []
synonym: "stimulation of myeloid cell apoptosis" NARROW []
synonym: "up regulation of myeloid cell apoptosis" EXACT []
synonym: "up-regulation of myeloid cell apoptosis" EXACT []
synonym: "upregulation of myeloid cell apoptosis" EXACT []
is_a: GO:0033032 ! regulation of myeloid cell apoptosis
is_a: GO:0043065 ! positive regulation of apoptosis
relationship: positively_regulates GO:0033028 ! myeloid cell apoptosis

[Term]
id: GO:0033036
name: macromolecule localization
namespace: biological_process
def: "Any process by which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah]
subset: gosubset_prok
is_a: GO:0051179 ! localization

[Term]
id: GO:0033037
name: polysaccharide localization
namespace: biological_process
def: "Any process by which a polysaccharide is transported to, or maintained in, a specific location." [GOC:mah]
subset: gosubset_prok
is_a: GO:0033036 ! macromolecule localization

[Term]
id: GO:0033038
name: bitter taste receptor activity
namespace: molecular_function
def: "Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste." [GOC:mah]
is_a: GO:0008527 ! taste receptor activity

[Term]
id: GO:0033039
name: salty taste receptor activity
namespace: molecular_function
def: "Combining with soluble salty compounds to initiate a change in cell activity. These receptors are responsible for the sense of salty taste." [GOC:mah]
is_a: GO:0008527 ! taste receptor activity

[Term]
id: GO:0033040
name: sour taste receptor activity
namespace: molecular_function
def: "Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste." [GOC:mah]
is_a: GO:0008527 ! taste receptor activity

[Term]
id: GO:0033041
name: sweet taste receptor activity
namespace: molecular_function
def: "Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste." [GOC:mah]
is_a: GO:0008527 ! taste receptor activity

[Term]
id: GO:0033042
name: umami taste receptor activity
namespace: molecular_function
def: "Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates." [GOC:mah]
is_a: GO:0008527 ! taste receptor activity

[Term]
id: GO:0033043
name: regulation of organelle organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah]
synonym: "regulation of organelle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0006996 ! organelle organization

[Term]
id: GO:0033044
name: regulation of chromosome organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah]
synonym: "regulation of chromosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0051276 ! chromosome organization

[Term]
id: GO:0033045
name: regulation of sister chromatid segregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0051983 ! regulation of chromosome segregation
relationship: regulates GO:0000819 ! sister chromatid segregation

[Term]
id: GO:0033046
name: negative regulation of sister chromatid segregation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." [GOC:mah]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0033045 ! regulation of sister chromatid segregation
relationship: negatively_regulates GO:0000819 ! sister chromatid segregation

[Term]
id: GO:0033047
name: regulation of mitotic sister chromatid segregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah]
is_a: GO:0007088 ! regulation of mitosis
is_a: GO:0033045 ! regulation of sister chromatid segregation
relationship: regulates GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0033048
name: negative regulation of mitotic sister chromatid segregation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah]
is_a: GO:0033046 ! negative regulation of sister chromatid segregation
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
relationship: negatively_regulates GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0033049
name: clavulanic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [ChEBI:3736, GOC:mah]
synonym: "clavulanic acid metabolism" EXACT []
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0033050
name: clavulanic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [ChEBI:3736, GOC:mah]
synonym: "clavulanic acid anabolism" EXACT []
synonym: "clavulanic acid biosynthesis" EXACT []
synonym: "clavulanic acid formation" EXACT []
synonym: "clavulanic acid synthesis" EXACT []
xref: Wikipedia:Clavulanic_acid
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0033049 ! clavulanic acid metabolic process
is_a: GO:0043604 ! amide biosynthetic process

[Term]
id: GO:0033051
name: aminophosphonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aminophosphonates, amino acid derivatives that contain a phosphonic acid moiety." [GOC:mah, http://pages.unibas.ch/mdpi/ecsoc/a0045/a0045.htm, http://www.genome.ad.jp/kegg/pathway/map/map00440.html]
synonym: "aminophosphonate metabolism" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process

[Term]
id: GO:0033052
name: cyanoamino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group." [GOC:mah, PMID:11575729]
synonym: "cyanoamino acid metabolism" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process

[Term]
id: GO:0033053
name: D-glutamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid." [ChEBI:17061, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-glutamine metabolism" EXACT []
is_a: GO:0006541 ! glutamine metabolic process
is_a: GO:0046144 ! D-alanine family amino acid metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0033054
name: D-glutamate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid." [ChEBI:15966, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-glutamate metabolism" EXACT []
is_a: GO:0006536 ! glutamate metabolic process
is_a: GO:0046144 ! D-alanine family amino acid metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0033055
name: D-arginine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid." [ChEBI:15816, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-arginine metabolism" EXACT []
is_a: GO:0006525 ! arginine metabolic process
is_a: GO:0046144 ! D-alanine family amino acid metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0033056
name: D-ornithine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid." [ChEBI:16176, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-ornithine metabolism" EXACT []
is_a: GO:0006591 ! ornithine metabolic process
is_a: GO:0046144 ! D-alanine family amino acid metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0033057
name: reproductive behavior in a multicellular organism
namespace: biological_process
def: "The specific actions or reactions of an organism that are associated with reproduction in a multicellular organism." [GOC:mtg_MIT_16mar07]
is_a: GO:0019098 ! reproductive behavior
is_a: GO:0048609 ! reproductive process in a multicellular organism

[Term]
id: GO:0033058
name: directional locomotion
namespace: biological_process
def: "Self-propelled movement of a cell or organism from one location to another along an axis." [GOC:mtg_MIT_16mar07]
is_a: GO:0040011 ! locomotion

[Term]
id: GO:0033059
name: cellular pigmentation
namespace: biological_process
def: "The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07]
subset: gosubset_prok
is_a: GO:0009987 ! cellular process
is_a: GO:0043473 ! pigmentation

[Term]
id: GO:0033060
name: ocellus pigmentation
namespace: biological_process
def: "The deposition or aggregation of coloring matter in an ocellus, a minute simple eye found in many invertebrates." [GOC:mtg_MIT_16mar07]
is_a: GO:0043473 ! pigmentation

[Term]
id: GO:0033061
name: DNA recombinase mediator complex
namespace: cellular_component
def: "A protein complex that promotes nucleoprotein filament formation during homologous recombination; most known examples contain two or more RecA family proteins (often Rad51 paralogs)." [GOC:elh, GOC:mah, GOC:vw]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0033062
name: Rhp55-Rhp57 complex
namespace: cellular_component
def: "A conserved heterodimeric DNA recombinase mediator complex that contains the RecA family proteins Rhp55p and Rph57 in Schizosaccharomyces, or orthologs thereof (e.g. Rad55p and Rad57p in Saccharomyces)." [GOC:mah, GOC:vw]
synonym: "Rad55-Rad57 complex" EXACT []
is_a: GO:0033061 ! DNA recombinase mediator complex

[Term]
id: GO:0033063
name: Rad51B-Rad51C-Rad51D-XRCC2 complex
namespace: cellular_component
def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795]
synonym: "BCDX2 complex" EXACT []
is_a: GO:0033061 ! DNA recombinase mediator complex

[Term]
id: GO:0033064
name: XRCC2-RAD51D complex
namespace: cellular_component
def: "A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast." [GOC:mah, GOC:vw, PMID:16093548]
synonym: "DX2 complex" EXACT []
is_a: GO:0033061 ! DNA recombinase mediator complex

[Term]
id: GO:0033065
name: Rad51C-XRCC3 complex
namespace: cellular_component
def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795]
synonym: "CX3 complex" EXACT []
is_a: GO:0033061 ! DNA recombinase mediator complex

[Term]
id: GO:0033066
name: Rad51B-Rad51C complex
namespace: cellular_component
def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795]
synonym: "BC complex" EXACT []
is_a: GO:0033061 ! DNA recombinase mediator complex

[Term]
id: GO:0033067
name: macrolide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar moieties. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:17298179]
subset: gosubset_prok
synonym: "macrolide metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0033068
name: macrolide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar moieties. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:17298179]
subset: gosubset_prok
synonym: "macrolide anabolism" EXACT []
synonym: "macrolide biosynthesis" EXACT []
synonym: "macrolide formation" EXACT []
synonym: "macrolide synthesis" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0033067 ! macrolide metabolic process

[Term]
id: GO:0033069
name: ansamycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GOC:mah, http://ww2.icho.edu.pl/cednets/rydzyna/meyer.htm]
subset: gosubset_prok
synonym: "ansamycin metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0030638 ! polyketide metabolic process
is_a: GO:0034311 ! diol metabolic process

[Term]
id: GO:0033070
name: ansamycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GOC:mah, http://ww2.icho.edu.pl/cednets/rydzyna/meyer.htm]
subset: gosubset_prok
synonym: "ansamycin anabolism" EXACT []
synonym: "ansamycin biosynthesis" EXACT []
synonym: "ansamycin formation" EXACT []
synonym: "ansamycin synthesis" EXACT []
is_a: GO:0030639 ! polyketide biosynthetic process
is_a: GO:0033069 ! ansamycin metabolic process

[Term]
id: GO:0033071
name: vancomycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria." [ChEBI:28001, GOC:mah]
subset: gosubset_prok
synonym: "vancomycin metabolism" EXACT []
is_a: GO:0030650 ! peptide antibiotic metabolic process

[Term]
id: GO:0033072
name: vancomycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria." [ChEBI:28001, GOC:mah]
subset: gosubset_prok
synonym: "vancomycin anabolism" EXACT []
synonym: "vancomycin biosynthesis" EXACT []
synonym: "vancomycin formation" EXACT []
synonym: "vancomycin synthesis" EXACT []
is_a: GO:0019184 ! nonribosomal peptide biosynthetic process
is_a: GO:0030651 ! peptide antibiotic biosynthetic process
is_a: GO:0033071 ! vancomycin metabolic process

[Term]
id: GO:0033073
name: pinene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane." [GOC:mah, http://www.chem.qmul.ac.uk/iubmb/enzyme/glossary/pinene.html]
subset: gosubset_prok
synonym: "pinene metabolism" EXACT []
is_a: GO:0016098 ! monoterpenoid metabolic process
is_a: GO:0043692 ! monoterpene metabolic process

[Term]
id: GO:0033074
name: pinene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the breakdown of the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane." [GOC:mah, http://www.chem.qmul.ac.uk/iubmb/enzyme/glossary/pinene.html]
synonym: "pinene breakdown" EXACT []
synonym: "pinene catabolism" EXACT []
synonym: "pinene degradation" EXACT []
is_a: GO:0016100 ! monoterpenoid catabolic process
is_a: GO:0033073 ! pinene metabolic process

[Term]
id: GO:0033075
name: isoquinoline alkaloid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html]
subset: gosubset_prok
synonym: "ipecac alkaloid biosynthesis" RELATED []
synonym: "isoquinoline alkaloid anabolism" EXACT []
synonym: "isoquinoline alkaloid biosynthesis" EXACT []
synonym: "isoquinoline alkaloid formation" EXACT []
synonym: "isoquinoline alkaloid synthesis" EXACT []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process

[Term]
id: GO:0033076
name: isoquinoline alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html]
subset: gosubset_prok
synonym: "ipecac alkaloid metabolism" RELATED []
synonym: "isoquinoline alkaloid metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0033077
name: T cell differentiation in the thymus
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "thymic T cell differentiation" EXACT []
synonym: "thymocyte cell differentiation" EXACT []
synonym: "thymocyte differentiation" EXACT []
is_a: GO:0030217 ! T cell differentiation

[Term]
id: GO:0033078
name: extrathymic T cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of a T cell via a differentiation pathway independent of the thymus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0030217 ! T cell differentiation

[Term]
id: GO:0033079
name: immature T cell proliferation
namespace: biological_process
def: "The expansion of an immature T cell population by cell division." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0042098 ! T cell proliferation

[Term]
id: GO:0033080
name: immature T cell proliferation in the thymus
namespace: biological_process
def: "The expansion of an immature T cell population by cell division in the thymus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "thymic T cell proliferation" EXACT []
synonym: "thymocyte cell proliferation" EXACT []
synonym: "thymocyte proliferation" EXACT []
is_a: GO:0033079 ! immature T cell proliferation
relationship: part_of GO:0033077 ! T cell differentiation in the thymus

[Term]
id: GO:0033081
name: regulation of T cell differentiation in the thymus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah]
synonym: "regulation of thymic T cell differentiation" EXACT []
synonym: "regulation of thymocyte cell differentiation" EXACT []
synonym: "regulation of thymocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
relationship: regulates GO:0033077 ! T cell differentiation in the thymus

[Term]
id: GO:0033082
name: regulation of extrathymic T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah]
is_a: GO:0045580 ! regulation of T cell differentiation
relationship: regulates GO:0033078 ! extrathymic T cell differentiation

[Term]
id: GO:0033083
name: regulation of immature T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah]
is_a: GO:0042129 ! regulation of T cell proliferation
relationship: regulates GO:0033079 ! immature T cell proliferation

[Term]
id: GO:0033084
name: regulation of immature T cell proliferation in the thymus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah]
synonym: "regulation of thymic T cell proliferation" EXACT []
synonym: "regulation of thymocyte cell proliferation" EXACT []
synonym: "regulation of thymocyte proliferation" EXACT []
is_a: GO:0033081 ! regulation of T cell differentiation in the thymus
is_a: GO:0033083 ! regulation of immature T cell proliferation
relationship: regulates GO:0033080 ! immature T cell proliferation in the thymus

[Term]
id: GO:0033085
name: negative regulation of T cell differentiation in the thymus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah]
synonym: "negative regulation of thymic T cell differentiation" EXACT []
synonym: "negative regulation of thymocyte cell differentiation" EXACT []
synonym: "negative regulation of thymocyte differentiation" EXACT []
is_a: GO:0033081 ! regulation of T cell differentiation in the thymus
is_a: GO:0045581 ! negative regulation of T cell differentiation
relationship: negatively_regulates GO:0033077 ! T cell differentiation in the thymus

[Term]
id: GO:0033086
name: negative regulation of extrathymic T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah]
is_a: GO:0033082 ! regulation of extrathymic T cell differentiation
is_a: GO:0045581 ! negative regulation of T cell differentiation
relationship: negatively_regulates GO:0033078 ! extrathymic T cell differentiation

[Term]
id: GO:0033087
name: negative regulation of immature T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah]
is_a: GO:0033083 ! regulation of immature T cell proliferation
is_a: GO:0042130 ! negative regulation of T cell proliferation
relationship: negatively_regulates GO:0033079 ! immature T cell proliferation

[Term]
id: GO:0033088
name: negative regulation of immature T cell proliferation in the thymus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah]
synonym: "negative regulation of thymic T cell proliferation" EXACT []
synonym: "negative regulation of thymocyte cell proliferation" EXACT []
synonym: "negative regulation of thymocyte proliferation" EXACT []
is_a: GO:0033084 ! regulation of immature T cell proliferation in the thymus
is_a: GO:0033087 ! negative regulation of immature T cell proliferation
relationship: negatively_regulates GO:0033080 ! immature T cell proliferation in the thymus

[Term]
id: GO:0033089
name: positive regulation of T cell differentiation in the thymus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah]
synonym: "positive regulation of thymic T cell differentiation" EXACT []
synonym: "positive regulation of thymocyte cell differentiation" EXACT []
synonym: "positive regulation of thymocyte differentiation" EXACT []
is_a: GO:0033081 ! regulation of T cell differentiation in the thymus
is_a: GO:0045582 ! positive regulation of T cell differentiation
relationship: positively_regulates GO:0033077 ! T cell differentiation in the thymus

[Term]
id: GO:0033090
name: positive regulation of extrathymic T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah]
is_a: GO:0033082 ! regulation of extrathymic T cell differentiation
is_a: GO:0045582 ! positive regulation of T cell differentiation
relationship: positively_regulates GO:0033078 ! extrathymic T cell differentiation

[Term]
id: GO:0033091
name: positive regulation of immature T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah]
is_a: GO:0033083 ! regulation of immature T cell proliferation
is_a: GO:0042102 ! positive regulation of T cell proliferation
relationship: positively_regulates GO:0033079 ! immature T cell proliferation

[Term]
id: GO:0033092
name: positive regulation of immature T cell proliferation in the thymus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah]
synonym: "positive regulation of thymic T cell proliferation" EXACT []
synonym: "positive regulation of thymocyte cell proliferation" EXACT []
synonym: "positive regulation of thymocyte proliferation" EXACT []
is_a: GO:0033084 ! regulation of immature T cell proliferation in the thymus
is_a: GO:0033091 ! positive regulation of immature T cell proliferation
relationship: positively_regulates GO:0033080 ! immature T cell proliferation in the thymus

[Term]
id: GO:0033093
name: Weibel-Palade body
namespace: cellular_component
def: "A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses." [PMID:11935287, PMID:16087708]
xref: Wikipedia:Weibel-Palade_body
is_a: GO:0030136 ! clathrin-coated vesicle
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0033094
name: butane-1,4-diamine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H(2)O." [EC:2.6.1.82, GOC:mlg]
synonym: "PAT activity" RELATED []
synonym: "putrescine aminotransferase activity" BROAD [EC:2.6.1.82]
synonym: "putrescine transaminase activity" BROAD []
synonym: "putrescine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.82]
synonym: "putrescine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.82]
synonym: "putrescine:alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.82]
synonym: "YgjG" RELATED [EC:2.6.1.82]
xref: EC:2.6.1.82
xref: MetaCyc:2.6.1.82-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0033095
name: aleurone grain
namespace: cellular_component
def: "A membrane-bounded storage granule found in cells of the aleurone layer in plants; contains either a protein matrix, protein-carbohydrate bodies and/or globoids. Aleurone grains are formed by the vacuole, rough endoplasmic reticulum and dictyosomes." [http://ejournal.sinica.edu.tw/bbas/content/2004/1/bot451-08.pdf, http://www.springerlink.com/content/q7183h5vr7358278/]
synonym: "aleurone body" EXACT []
is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0033096
name: amyloplast envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the amyloplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah]
is_a: GO:0009526 ! plastid envelope
relationship: part_of GO:0009501 ! amyloplast

[Term]
id: GO:0033097
name: amyloplast membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround an amyloplast and form the amyloplast envelope." [GOC:ecd]
is_a: GO:0042170 ! plastid membrane
relationship: part_of GO:0033096 ! amyloplast envelope

[Term]
id: GO:0033098
name: amyloplast inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the amyloplast envelope; also faces the amyloplast stroma." [GOC:ecd]
is_a: GO:0009528 ! plastid inner membrane
is_a: GO:0033097 ! amyloplast membrane

[Term]
id: GO:0033099
name: attachment organelle
namespace: cellular_component
def: "A membrane-bounded extension of the cell, originally characterized in Mycoplasma species, that contains an electron-dense core that is part of the cytoskeleton and is oriented lengthwise and ends distally in a bulbous knob (terminal button). Required for adherence to host cells and involved in gliding motility and cell division." [http://authors.library.caltech.edu/3529/, PMID:11325545, PMID:12003948]
subset: goslim_pir
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0033100
name: NuA3 histone acetyltransferase complex
namespace: cellular_component
def: "A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p." [PMID:10817755, PMID:17157260]
is_a: GO:0070775 ! H3 histone acetyltransferase complex

[Term]
id: GO:0033101
name: cellular bud membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a cellular bud." [GOC:mah]
synonym: "cellular bud plasma membrane" EXACT []
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005933 ! cellular bud

[Term]
id: GO:0033102
name: acidocalcisome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an acidocalcisome." [GOC:ecd, PMID:11378195]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0020022 ! acidocalcisome

[Term]
id: GO:0033103
name: protein secretion by the type VI secretion system
namespace: biological_process
def: "The process by which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type VI protein secretion system complex ; GO:0033104'.
synonym: "protein secretion by the T6SS" EXACT []
synonym: "protein secretion by the type VI protein secretion system" EXACT []
synonym: "type VI protein secretion system" EXACT []
is_a: GO:0009306 ! protein secretion

[Term]
id: GO:0033104
name: type VI protein secretion system complex
namespace: cellular_component
def: "A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151]
subset: gosubset_prok
synonym: "T6SS complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0033105
name: chlorosome envelope
namespace: cellular_component
def: "The structure, composed of a monolayer of glycolipids with embedded proteins, that encloses the pigments and other contents of the chlorosome." [PMID:14507718, PMID:14729689, PMID:17303128]
comment: Note that the chlorosome envelope is not a single or double lipid bilayer, so this term is not a child of 'organelle membrane ; GO:0031090' or 'organelle envelope ; GO:0031967'.
synonym: "chlorosome membrane" EXACT []
is_a: GO:0034646 ! organelle-enclosing lipid monolayer
relationship: part_of GO:0046858 ! chlorosome

[Term]
id: GO:0033106
name: cis-Golgi network membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network." [GOC:mah]
synonym: "cis Golgi network membrane" EXACT []
synonym: "Golgi cis face membrane" RELATED []
is_a: GO:0000139 ! Golgi membrane
relationship: part_of GO:0005801 ! cis-Golgi network

[Term]
id: GO:0033107
name: CVT vesicle
namespace: cellular_component
def: "A cytosolic vesicle that is enclosed by a double membrane and is implicated in the cytoplasm to vacuole targeting pathway. These vesicles are found in the yeast S. cerevisiae, and contain vacuolar hydrolases, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p)." [GOC:rb, PMID:15138258]
is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0033108
name: mitochondrial respiratory chain complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex." [GOC:mah]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0007005 ! mitochondrion organization

[Term]
id: GO:0033109
name: cortical actin cytoskeleton stabilization
namespace: biological_process
def: "The process by which the assembly and arrangement of cytoskeletal structures in the actin cortex with respect to the plasma membrane is maintained." [GOC:mah, GOC:pf]
synonym: "actin cortex stabilization" EXACT []
synonym: "cortical resistance" RELATED []
is_a: GO:0030866 ! cortical actin cytoskeleton organization

[Term]
id: GO:0033110
name: CVT vesicle membrane
namespace: cellular_component
def: "The double lipid bilayer surrounding a CVT vesicle." [GOC:ecd]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0033107 ! CVT vesicle

[Term]
id: GO:0033111
name: attachment organelle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an attachment organelle." [GOC:ecd]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0033099 ! attachment organelle

[Term]
id: GO:0033112
name: cyanelle envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the cyanelle and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah]
is_a: GO:0009526 ! plastid envelope
relationship: part_of GO:0009842 ! cyanelle

[Term]
id: GO:0033113
name: cyanelle membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a cyanelle and form the cyanelle envelope." [GOC:ecd]
is_a: GO:0042170 ! plastid membrane
relationship: part_of GO:0033112 ! cyanelle envelope

[Term]
id: GO:0033114
name: cyanelle thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by a cyanelle thylakoid membrane." [GOC:mah]
is_a: GO:0031978 ! plastid thylakoid lumen
relationship: part_of GO:0009843 ! cyanelle thylakoid

[Term]
id: GO:0033115
name: cyanelle thylakoid membrane
namespace: cellular_component
def: "The lipid bilayer membrane of any thylakoid within a cyanelle." [GOC:mah]
is_a: GO:0055035 ! plastid thylakoid membrane
relationship: part_of GO:0009843 ! cyanelle thylakoid

[Term]
id: GO:0033116
name: ER-Golgi intermediate compartment membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments of the ER-Golgi intermediate compartment system." [GOC:mah, PMID:16723730]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0005793 ! ER-Golgi intermediate compartment

[Term]
id: GO:0033117
name: esterosome
namespace: cellular_component
def: "A vesicle filled with crystalline protein that shows sequence similarities with various esterases." [GOC:ecd, PMID:2307702]
is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0033118
name: esterosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding an esterosome. This membrane has characteristics of rough endoplasmic reticulum (RER) membranes." [GOC:ecd, PMID:2307702]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0033117 ! esterosome

[Term]
id: GO:0033119
name: negative regulation of RNA splicing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA splicing." [GOC:mah]
is_a: GO:0043484 ! regulation of RNA splicing
is_a: GO:0051253 ! negative regulation of RNA metabolic process
relationship: negatively_regulates GO:0008380 ! RNA splicing

[Term]
id: GO:0033120
name: positive regulation of RNA splicing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA splicing." [GOC:mah]
is_a: GO:0043484 ! regulation of RNA splicing
is_a: GO:0051254 ! positive regulation of RNA metabolic process
relationship: positively_regulates GO:0008380 ! RNA splicing

[Term]
id: GO:0033121
name: regulation of purine nucleotide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah]
synonym: "regulation of purine nucleotide breakdown" EXACT []
synonym: "regulation of purine nucleotide catabolism" EXACT []
synonym: "regulation of purine nucleotide degradation" EXACT []
is_a: GO:0030811 ! regulation of nucleotide catabolic process
relationship: regulates GO:0006195 ! purine nucleotide catabolic process

[Term]
id: GO:0033122
name: negative regulation of purine nucleotide catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah]
synonym: "negative regulation of purine nucleotide breakdown" EXACT []
synonym: "negative regulation of purine nucleotide catabolism" EXACT []
synonym: "negative regulation of purine nucleotide degradation" EXACT []
is_a: GO:0030812 ! negative regulation of nucleotide catabolic process
is_a: GO:0033121 ! regulation of purine nucleotide catabolic process
relationship: negatively_regulates GO:0006195 ! purine nucleotide catabolic process

[Term]
id: GO:0033123
name: positive regulation of purine nucleotide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah]
synonym: "positive regulation of purine nucleotide breakdown" EXACT []
synonym: "positive regulation of purine nucleotide catabolism" EXACT []
synonym: "positive regulation of purine nucleotide degradation" EXACT []
is_a: GO:0030813 ! positive regulation of nucleotide catabolic process
is_a: GO:0033121 ! regulation of purine nucleotide catabolic process
relationship: positively_regulates GO:0006195 ! purine nucleotide catabolic process

[Term]
id: GO:0033124
name: regulation of GTP catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah]
synonym: "regulation of GTP breakdown" EXACT []
synonym: "regulation of GTP catabolism" EXACT []
synonym: "regulation of GTP degradation" EXACT []
is_a: GO:0033121 ! regulation of purine nucleotide catabolic process
relationship: regulates GO:0006184 ! GTP catabolic process

[Term]
id: GO:0033125
name: negative regulation of GTP catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah]
synonym: "negative regulation of GTP breakdown" EXACT []
synonym: "negative regulation of GTP catabolism" EXACT []
synonym: "negative regulation of GTP degradation" EXACT []
is_a: GO:0033122 ! negative regulation of purine nucleotide catabolic process
is_a: GO:0033124 ! regulation of GTP catabolic process
relationship: negatively_regulates GO:0006184 ! GTP catabolic process

[Term]
id: GO:0033126
name: positive regulation of GTP catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah]
synonym: "positive regulation of GTP breakdown" EXACT []
synonym: "positive regulation of GTP catabolism" EXACT []
synonym: "positive regulation of GTP degradation" EXACT []
is_a: GO:0033123 ! positive regulation of purine nucleotide catabolic process
is_a: GO:0033124 ! regulation of GTP catabolic process
relationship: positively_regulates GO:0006184 ! GTP catabolic process

[Term]
id: GO:0033127
name: regulation of histone phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah]
is_a: GO:0001932 ! regulation of protein amino acid phosphorylation
is_a: GO:0031056 ! regulation of histone modification
relationship: regulates GO:0016572 ! histone phosphorylation

[Term]
id: GO:0033128
name: negative regulation of histone phosphorylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah]
is_a: GO:0001933 ! negative regulation of protein amino acid phosphorylation
is_a: GO:0031057 ! negative regulation of histone modification
is_a: GO:0033127 ! regulation of histone phosphorylation
relationship: negatively_regulates GO:0016572 ! histone phosphorylation

[Term]
id: GO:0033129
name: positive regulation of histone phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah]
is_a: GO:0001934 ! positive regulation of protein amino acid phosphorylation
is_a: GO:0031058 ! positive regulation of histone modification
is_a: GO:0033127 ! regulation of histone phosphorylation
relationship: positively_regulates GO:0016572 ! histone phosphorylation

[Term]
id: GO:0033130
name: acetylcholine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an acetylcholine receptor." [GOC:mah]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0033131
name: regulation of glucokinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah]
synonym: "glucokinase regulator" NARROW []
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0043549 ! regulation of kinase activity

[Term]
id: GO:0033132
name: negative regulation of glucokinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah]
synonym: "down regulation of glucokinase activity" EXACT []
synonym: "down-regulation of glucokinase activity" EXACT []
synonym: "downregulation of glucokinase activity" EXACT []
synonym: "glucokinase inhibitor" NARROW []
synonym: "inhibition of glucokinase activity" NARROW []
is_a: GO:0033131 ! regulation of glucokinase activity
is_a: GO:0033673 ! negative regulation of kinase activity

[Term]
id: GO:0033133
name: positive regulation of glucokinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah]
synonym: "glucokinase activator" NARROW []
synonym: "stimulation of glucokinase activity" NARROW []
synonym: "up regulation of glucokinase activity" EXACT []
synonym: "up-regulation of glucokinase activity" EXACT []
synonym: "upregulation of glucokinase activity" EXACT []
is_a: GO:0033131 ! regulation of glucokinase activity
is_a: GO:0033674 ! positive regulation of kinase activity

[Term]
id: GO:0033134
name: ubiquitin activating enzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a ubiquitin activating enzyme, any of the E1 proteins." [GOC:mah]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0033135
name: regulation of peptidyl-serine phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]
subset: gosubset_prok
is_a: GO:0001932 ! regulation of protein amino acid phosphorylation
relationship: regulates GO:0018105 ! peptidyl-serine phosphorylation

[Term]
id: GO:0033136
name: serine phosphorylation of STAT3 protein
namespace: biological_process
def: "The process of introducing a phosphate group to a serine residue of the STAT3 protein." [GOC:jl, GOC:mah]
is_a: GO:0042501 ! serine phosphorylation of STAT protein

[Term]
id: GO:0033137
name: negative regulation of peptidyl-serine phosphorylation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]
is_a: GO:0001933 ! negative regulation of protein amino acid phosphorylation
is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation
relationship: negatively_regulates GO:0018105 ! peptidyl-serine phosphorylation

[Term]
id: GO:0033138
name: positive regulation of peptidyl-serine phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah]
is_a: GO:0001934 ! positive regulation of protein amino acid phosphorylation
is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation
relationship: positively_regulates GO:0018105 ! peptidyl-serine phosphorylation

[Term]
id: GO:0033139
name: regulation of peptidyl-serine phosphorylation of STAT protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah]
is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation
relationship: part_of GO:0042501 ! serine phosphorylation of STAT protein

[Term]
id: GO:0033140
name: negative regulation of peptidyl-serine phosphorylation of STAT protein
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah]
is_a: GO:0033137 ! negative regulation of peptidyl-serine phosphorylation
is_a: GO:0033139 ! regulation of peptidyl-serine phosphorylation of STAT protein

[Term]
id: GO:0033141
name: positive regulation of peptidyl-serine phosphorylation of STAT protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah]
is_a: GO:0033138 ! positive regulation of peptidyl-serine phosphorylation
is_a: GO:0033139 ! regulation of peptidyl-serine phosphorylation of STAT protein

[Term]
id: GO:0033142
name: progesterone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a progesterone receptor." [GOC:mah]
is_a: GO:0035258 ! steroid hormone receptor binding

[Term]
id: GO:0033143
name: regulation of steroid hormone receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of any steroid hormone receptor signaling pathway." [GOC:mah]
synonym: "regulation of steroid hormone receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0030518 ! steroid hormone receptor signaling pathway

[Term]
id: GO:0033144
name: negative regulation of steroid hormone receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any steroid hormone receptor signaling pathway." [GOC:mah]
synonym: "negative regulation of steroid hormone receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0033143 ! regulation of steroid hormone receptor signaling pathway
relationship: negatively_regulates GO:0030518 ! steroid hormone receptor signaling pathway

[Term]
id: GO:0033145
name: positive regulation of steroid hormone receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of any steroid hormone receptor signaling pathway." [GOC:mah]
synonym: "positive regulation of steroid hormone receptor signalling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0033143 ! regulation of steroid hormone receptor signaling pathway
relationship: positively_regulates GO:0030518 ! steroid hormone receptor signaling pathway

[Term]
id: GO:0033146
name: regulation of estrogen receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of an estrogen receptor signaling pathway." [GOC:mah]
synonym: "regulation of estrogen receptor signalling pathway" EXACT []
is_a: GO:0033143 ! regulation of steroid hormone receptor signaling pathway
relationship: regulates GO:0030520 ! estrogen receptor signaling pathway

[Term]
id: GO:0033147
name: negative regulation of estrogen receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an estrogen receptor signaling pathway." [GOC:mah]
synonym: "negative regulation of estrogen receptor signalling pathway" EXACT []
is_a: GO:0033144 ! negative regulation of steroid hormone receptor signaling pathway
is_a: GO:0033146 ! regulation of estrogen receptor signaling pathway
relationship: negatively_regulates GO:0030520 ! estrogen receptor signaling pathway

[Term]
id: GO:0033148
name: positive regulation of estrogen receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of an estrogen receptor signaling pathway." [GOC:mah]
synonym: "positive regulation of estrogen receptor signalling pathway" EXACT []
is_a: GO:0033145 ! positive regulation of steroid hormone receptor signaling pathway
is_a: GO:0033146 ! regulation of estrogen receptor signaling pathway
relationship: positively_regulates GO:0030520 ! estrogen receptor signaling pathway

[Term]
id: GO:0033149
name: FFAT motif binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family." [PMID:12727870, PMID:15455074, PMID:16004875]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0033150
name: cytoskeletal calyx
namespace: cellular_component
def: "A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins." [PMID:12243744, PMID:9184090]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0033011 ! perinuclear theca

[Term]
id: GO:0033151
name: V(D)J recombination
namespace: biological_process
def: "The process by which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781700221, ISBN:0781735149 "Fundamental Immunology"]
synonym: "V(D)J joining" EXACT []
synonym: "V-D-J joining" EXACT []
synonym: "V-D-J recombination" EXACT []
synonym: "V-J joining" EXACT []
synonym: "V-J recombination" EXACT []
xref: Wikipedia:V(D)J_recombination
is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus

[Term]
id: GO:0033152
name: immunoglobulin V(D)J recombination
namespace: biological_process
def: "The process by which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin light chains the same process is used to join V and J gene segments directly." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "immunoglobulin V(D)J joining" EXACT []
synonym: "immunoglobulin V-D-J joining" EXACT []
synonym: "immunoglobulin V-D-J recombination" EXACT []
synonym: "immunoglobulin V-J joining" EXACT []
synonym: "immunoglobulin V-J recombination" EXACT []
is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments
is_a: GO:0033151 ! V(D)J recombination

[Term]
id: GO:0033153
name: T cell receptor V(D)J recombination
namespace: biological_process
def: "The process by which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781700221]
synonym: "T cell receptor V(D)J joining" EXACT []
synonym: "T cell receptor V-D-J joining" EXACT []
synonym: "T cell receptor V-D-J recombination" EXACT []
synonym: "T cell receptor V-J joining" EXACT []
synonym: "T cell receptor V-J recombination" EXACT []
synonym: "T-cell receptor V(D)J recombination" EXACT []
synonym: "TCR V(D)J recombination" EXACT []
is_a: GO:0002681 ! somatic recombination of T cell receptor gene segments
is_a: GO:0033151 ! V(D)J recombination

[Term]
id: GO:0033154
name: oligogalacturonide transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in)." [GOC:mlg]
is_a: GO:0015422 ! oligosaccharide-transporting ATPase activity
is_a: GO:0015478 ! oligosaccharide transporting porin activity

[Term]
id: GO:0033155
name: oligogalacturonide transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of oligogalacturonide from one side of the membrane to the other." [GOC:mlg]
is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity

[Term]
id: GO:0033156
name: oligogalacturonide transport
namespace: biological_process
def: "The directed movement of oligogalacturonides into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mlg]
is_a: GO:0015772 ! oligosaccharide transport

[Term]
id: GO:0033157
name: regulation of intracellular protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0051223 ! regulation of protein transport
relationship: regulates GO:0006886 ! intracellular protein transport

[Term]
id: GO:0033158
name: regulation of protein import into nucleus, translocation
namespace: biological_process
def: "Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah]
synonym: "regulation of protein import into cell nucleus, translocation" EXACT []
is_a: GO:0042306 ! regulation of protein import into nucleus
relationship: regulates GO:0000060 ! protein import into nucleus, translocation

[Term]
id: GO:0033159
name: negative regulation of protein import into nucleus, translocation
namespace: biological_process
def: "Any process that stops, prevents or reduces the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah]
synonym: "negative regulation of protein import into cell nucleus, translocation" EXACT []
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0033158 ! regulation of protein import into nucleus, translocation
is_a: GO:0051224 ! negative regulation of protein transport
relationship: negatively_regulates GO:0000060 ! protein import into nucleus, translocation

[Term]
id: GO:0033160
name: positive regulation of protein import into nucleus, translocation
namespace: biological_process
def: "Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah]
synonym: "positive regulation of protein import into cell nucleus, translocation" EXACT []
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0033158 ! regulation of protein import into nucleus, translocation
is_a: GO:0051222 ! positive regulation of protein transport
relationship: positively_regulates GO:0000060 ! protein import into nucleus, translocation

[Term]
id: GO:0033161
name: mitogen-activated protein kinase kinase kinase kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase kinase." [GOC:mah]
synonym: "MAPKKKK binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0033162
name: melanosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a melanosome." [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0042470 ! melanosome
relationship: part_of GO:0045009 ! chitosome

[Term]
id: GO:0033163
name: microneme membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a microneme." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0020009 ! microneme

[Term]
id: GO:0033164
name: glycolipid 6-alpha-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,6-D-mannosyl-D-mannose linkage." [EC:2.4.1.232, GOC:mcc, PMID:16878994]
synonym: "GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.232]
synonym: "GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.232]
synonym: "initiation-specific alpha-1,6-mannosyltransferase activity" EXACT [EC:2.4.1.232]
xref: EC:2.4.1.232
xref: MetaCyc:2.4.1.232-RXN
is_a: GO:0000009 ! alpha-1,6-mannosyltransferase activity
is_a: GO:0004376 ! glycolipid mannosyltransferase activity

[Term]
id: GO:0033165
name: interphotoreceptor matrix
namespace: cellular_component
def: "A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance." [http://www.glycoforum.gr.jp/science/hyaluronan/HA17/HA17E.html, PMID:1862095, PMID:2194288]
is_a: GO:0005578 ! proteinaceous extracellular matrix

[Term]
id: GO:0033166
name: hyaline layer
namespace: cellular_component
def: "A multilayered extraembryonic matrix that functions as a substrate for cell adhesion through early development. It is thought to protect and lubricate the embryo, stabilize the blastomeres during morphogenesis, and regulate nutrient intake. The major constituent of the hyaline layer is the protein hyalin. This matrix has been found in echinoderms." [http://worms.zoology.wisc.edu/urchins/SUgast_ECM3.html, PMID:1721506, PMID:9473317]
is_a: GO:0005578 ! proteinaceous extracellular matrix

[Term]
id: GO:0033167
name: ARC complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA." [GOC:vw, PMID:17310250]
synonym: "argonaute siRNA chaperone complex" EXACT []
is_a: GO:0031332 ! RNAi effector complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0033168
name: conversion of ds siRNA to ss siRNA involved in RNA interference
namespace: biological_process
def: "The process by which double-stranded siRNA molecules are converted to single-stranded siRNAs; required for the formation of a mature RITS complex during RNA interference." [GOC:mah, PMID:17310250]
synonym: "RNA interference, conversion of ds siRNA to ss siRNA" EXACT [GOC:mah]
is_a: GO:0006396 ! RNA processing
relationship: part_of GO:0030422 ! production of siRNA involved in RNA interference

[Term]
id: GO:0033169
name: histone H3-K9 demethylation
namespace: biological_process
def: "The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone." [GOC:mah]
is_a: GO:0070076 ! histone lysine demethylation

[Term]
id: GO:0033170
name: protein-DNA loading ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the assembly of a protein or protein complex onto a DNA molecule." [GOC:mah, GOC:vw]
synonym: "DNA-protein loading ATPase activity" EXACT [GOC:mah]
is_a: GO:0008094 ! DNA-dependent ATPase activity

[Term]
id: GO:0033171
name: nucleoprotein filament-forming ATPase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the assembly of proteins such as Rad51p onto single-stranded (ss) DNA to form a helical nucleoprotein filament." [GOC:mah, GOC:vw]
comment: This term was made obsolete because nucleoprotein filament formation does not require ATP hydrolysis, so the term is misleading.
is_obsolete: true

[Term]
id: GO:0033172
name: gas vesicle shell
namespace: cellular_component
def: "The proteinaceous structure surrounding a gas vesicle." [GOC:ecd]
synonym: "gas vesicle membrane" RELATED []
synonym: "gas vesicle wall" EXACT []
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0031411 ! gas vesicle

[Term]
id: GO:0033173
name: calcineurin-NFAT signaling pathway
namespace: biological_process
def: "A series of molecular signals that results in activation of transcription by a member of the NFAT protein family as a consequence of NFAT dephosphorylation by activated calcineurin. The signaling is generated by a receptor binding a ligand, followed by activation of phospholipase C and the subsequent release of inositol trisphosphate, which in turn leads to an increase in intracellular calcium ion concentration that mediates the activation of calcineurin." [GOC:lm, GOC:mah, PMID:15928679]
synonym: "calcineurin-NFAT signalling pathway" EXACT []
is_a: GO:0019722 ! calcium-mediated signaling
is_a: GO:0023034 ! intracellular signaling pathway
is_a: GO:0048016 ! inositol phosphate-mediated signaling

[Term]
id: GO:0033174
name: chloroplast proton-transporting ATP synthase complex, catalytic core CF(1)
namespace: cellular_component
def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the chloroplast thylakoid membrane when the entire ATP synthase is assembled. The chloroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits." [GOC:mah, GOC:pj, PMID:11032839]
synonym: "chloroplast proton-transporting F-type ATPase complex, catalytic core CF(1)" EXACT []
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)
relationship: part_of GO:0045320 ! chloroplast proton-transporting ATP synthase complex

[Term]
id: GO:0033175
name: chloroplast proton-transporting ATP synthase complex, coupling factor CF(o)
namespace: cellular_component
def: "All non-F1 subunits of the chloroplast hydrogen-transporting ATP synthase, including integral and peripheral chloroplast thylakoid membrane proteins." [GOC:mah]
synonym: "chloroplast proton-transporting ATP synthase complex, coupling factor CF(0)" EXACT []
synonym: "chloroplast proton-transporting F-type ATPase complex, coupling factor CF(o)" EXACT []
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o)
relationship: part_of GO:0045320 ! chloroplast proton-transporting ATP synthase complex

[Term]
id: GO:0033176
name: proton-transporting V-type ATPase complex
namespace: cellular_component
def: "A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane." [GOC:mah, ISBN:0716743663, PMID:16449553]
synonym: "hydrogen-translocating V-type ATPase complex" EXACT []
is_a: GO:0016469 ! proton-transporting two-sector ATPase complex

[Term]
id: GO:0033177
name: proton-transporting two-sector ATPase complex, proton-transporting domain
namespace: cellular_component
def: "A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0016469 ! proton-transporting two-sector ATPase complex

[Term]
id: GO:0033178
name: proton-transporting two-sector ATPase complex, catalytic domain
namespace: cellular_component
def: "A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0016469 ! proton-transporting two-sector ATPase complex

[Term]
id: GO:0033179
name: proton-transporting V-type ATPase, V0 domain
namespace: cellular_component
def: "A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553]
is_a: GO:0033177 ! proton-transporting two-sector ATPase complex, proton-transporting domain
relationship: part_of GO:0033176 ! proton-transporting V-type ATPase complex

[Term]
id: GO:0033180
name: proton-transporting V-type ATPase, V1 domain
namespace: cellular_component
def: "A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553]
is_a: GO:0033178 ! proton-transporting two-sector ATPase complex, catalytic domain
relationship: part_of GO:0033176 ! proton-transporting V-type ATPase complex

[Term]
id: GO:0033181
name: plasma membrane proton-transporting V-type ATPase complex
namespace: cellular_component
def: "A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah]
synonym: "plasma membrane hydrogen ion-transporting ATPase" EXACT []
is_a: GO:0033176 ! proton-transporting V-type ATPase complex

[Term]
id: GO:0033182
name: regulation of histone ubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of a ubiquitin moiety to a histone protein." [GOC:mah]
is_a: GO:0031056 ! regulation of histone modification
is_a: GO:0031396 ! regulation of protein ubiquitination
relationship: regulates GO:0016574 ! histone ubiquitination

[Term]
id: GO:0033183
name: negative regulation of histone ubiquitination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the addition of a ubiquitin moiety to a histone protein." [GOC:mah]
is_a: GO:0031057 ! negative regulation of histone modification
is_a: GO:0031397 ! negative regulation of protein ubiquitination
is_a: GO:0033182 ! regulation of histone ubiquitination
relationship: negatively_regulates GO:0016574 ! histone ubiquitination

[Term]
id: GO:0033184
name: positive regulation of histone ubiquitination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin moiety to a histone protein." [GOC:mah]
is_a: GO:0031058 ! positive regulation of histone modification
is_a: GO:0031398 ! positive regulation of protein ubiquitination
is_a: GO:0033182 ! regulation of histone ubiquitination
relationship: positively_regulates GO:0016574 ! histone ubiquitination

[Term]
id: GO:0033185
name: dolichol-phosphate-mannose synthase complex
namespace: cellular_component
def: "A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively." [PMID:10835346]
synonym: "dolichyl-phosphate beta-D-mannosyltransferase complex" EXACT []
synonym: "DPM synthase complex" EXACT []
is_a: GO:0031501 ! mannosyltransferase complex

[Term]
id: GO:0033186
name: CAF-1 complex
namespace: cellular_component
def: "A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48." [PMID:17065558, PMID:17083276]
synonym: "chromatin assembly factor 1 complex" EXACT []
is_a: GO:0005678 ! chromatin assembly complex

[Term]
id: GO:0033187
name: inositol hexakisphosphate 4-kinase or 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate or ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [PMID:17412958, PMID:17412959]
is_a: GO:0000828 ! inositol hexakisphosphate kinase activity

[Term]
id: GO:0033188
name: sphingomyelin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol." [EC:2.7.8.27]
synonym: "ceramide:phosphatidylcholine cholinephosphotransferase activity" EXACT [EC:2.7.8.27]
synonym: "phosphatidylcholine:ceramide cholinephosphotransferase activity" EXACT [EC:2.7.8.27]
synonym: "SM synthase activity" EXACT [EC:2.7.8.27]
synonym: "SMS1" RELATED [EC:2.7.8.27]
synonym: "SMS2" RELATED [EC:2.7.8.27]
xref: EC:2.7.8.27
xref: MetaCyc:2.7.8.27-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0033189
name: response to vitamin A
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus." [GOC:sl]
synonym: "response to retinol" NARROW []
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0033190
name: solanapyrone synthase activity
namespace: molecular_function
def: "Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A." [GOC:cb, PMID:9659400]
is_a: GO:0009975 ! cyclase activity

[Term]
id: GO:0033191
name: macrophomate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate." [ChEBI:38228, GOC:cb, PMID:10984474]
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0033192
name: calmodulin-dependent protein phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin." [GOC:mah, PMID:15359118]
synonym: "Ca2+/CaM-dependent protein phosphatase activity" RELATED []
synonym: "calcineurin activity" NARROW []
synonym: "calcium- and calmodulin-dependent protein phosphatase activity" EXACT []
synonym: "calcium/calmodulin-dependent protein phosphatase activity" EXACT []
is_a: GO:0004723 ! calcium-dependent protein serine/threonine phosphatase activity

[Term]
id: GO:0033193
name: Lsd1/2 complex
namespace: cellular_component
def: "A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast." [GOC:vw, PMID:17371846, PMID:17434129, PMID:17440621]
synonym: "SAPHIRE complex" EXACT [PMID:17371846]
synonym: "Swm complex" EXACT [PMID:17440621]
synonym: "Swm1/2 complex" RELATED [PMID:17440621]
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0033194
name: response to hydroperoxide
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH." [ChEBI:35923, GOC:mah]
subset: gosubset_prok
is_a: GO:0006979 ! response to oxidative stress

[Term]
id: GO:0033195
name: response to alkyl hydroperoxide
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group." [ChEBI:35923, GOC:mah]
is_a: GO:0033194 ! response to hydroperoxide

[Term]
id: GO:0033196
name: tryparedoxin peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: tryparedoxin + H2O2 = tryparedoxin disulfide + H2O." [GOC:mah]
synonym: "TXNPx activity" EXACT []
xref: MetaCyc:1.11.1.15-RXN
is_a: GO:0004601 ! peroxidase activity
is_a: GO:0051920 ! peroxiredoxin activity

[Term]
id: GO:0033197
name: response to vitamin E
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus." [GOC:sl]
synonym: "response to DL-alpha-tocopherol acetate" NARROW []
synonym: "response to DL-alpha-tocopheryl acetate" NARROW []
synonym: "response to O-Acetyl-alpha-tocopherol" NARROW []
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0033198
name: response to ATP
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:sl]
synonym: "response to adenosine 5'-triphosphate" EXACT []
synonym: "response to adenosine triphosphate" EXACT []
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0033199
name: inositol heptakisphosphate 4-kinase or 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, or ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [PMID:17412958]
is_a: GO:0000829 ! inositol heptakisphosphate kinase activity

[Term]
id: GO:0033200
name: inositol heptakisphosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, or ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [PMID:17412958]
synonym: "diphosphoinositol-pentakisphosphate 5-kinase activity" EXACT []
synonym: "IP7 5-kinase activity" EXACT []
is_a: GO:0000829 ! inositol heptakisphosphate kinase activity

[Term]
id: GO:0033201
name: alpha-1,4-glucan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP." [PMID:17472966]
synonym: "1,4-alpha-glucan synthase activity" EXACT []
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0033202
name: DNA helicase complex
namespace: cellular_component
def: "A protein complex that possesses DNA helicase activity." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0033203
name: DNA helicase A complex
namespace: cellular_component
def: "A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction." [PMID:9341218]
is_a: GO:0033202 ! DNA helicase complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0033204
name: ribonuclease P RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the RNA subunit of ribonuclease P." [GOC:pg, PMID:11455963]
synonym: "RNase P RNA binding" EXACT []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0033205
name: cytokinesis during cell cycle
namespace: biological_process
def: "Cytokinesis that occurs in the context of cell cycle progression and result in the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah]
is_a: GO:0000910 ! cytokinesis
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0033206
name: cytokinesis after meiosis
namespace: biological_process
def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells." [GOC:mah]
is_a: GO:0033205 ! cytokinesis during cell cycle

[Term]
id: GO:0033207
name: beta-1,4-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage." [GOC:mah]
synonym: "beta-1,4-GalNAc transferase activity" EXACT []
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0033208
name: UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide." [GOC:mah, PMID:12678917, PMID:16024623]
synonym: "Sda beta 1,4GalNAc transferase" RELATED []
synonym: "UDP-GalNAc:Neu5Ac-alpha-2-Gal-beta-1-R beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT []
is_a: GO:0033207 ! beta-1,4-N-acetylgalactosaminyltransferase activity

[Term]
id: GO:0033209
name: tumor necrosis factor-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:mah]
synonym: "adipocytokine signaling pathway" RELATED []
synonym: "TNF-alpha-mediated signaling pathway" EXACT []
synonym: "tumor necrosis factor alpha-mediated signaling pathway" EXACT []
synonym: "tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0033210
name: leptin-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of leptin binding to a cell surface receptor." [GOC:mah]
synonym: "adipocytokine signaling pathway" RELATED []
synonym: "leptin-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0033211
name: adiponectin-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of adiponectin binding to a cell surface receptor." [GOC:mah]
synonym: "adipocytokine signaling pathway" RELATED []
synonym: "adiponectin-mediated signalling pathway" EXACT []
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0033212
name: iron assimilation
namespace: biological_process
def: "A process by which iron is solubilized and transported into a cell." [GOC:mah]
is_a: GO:0006879 ! cellular iron ion homeostasis

[Term]
id: GO:0033213
name: iron assimilation by capture and transport
namespace: biological_process
def: "A process by which iron (Fe3+) is solubilized by binding to a receptor or transport protein and transported into a cell." [GOC:mah]
is_a: GO:0033212 ! iron assimilation

[Term]
id: GO:0033214
name: iron assimilation by chelation and transport
namespace: biological_process
def: "A process by which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors." [GOC:mah, PMID:16963626]
is_a: GO:0033212 ! iron assimilation

[Term]
id: GO:0033215
name: iron assimilation by reduction and transport
namespace: biological_process
def: "A process by which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins." [GOC:mah, PMID:16963626]
is_a: GO:0033212 ! iron assimilation

[Term]
id: GO:0033216
name: ferric iron import
namespace: biological_process
def: "The directed movement of ferric iron (Fe(III) or Fe3+) ions into a cell or organelle." [GOC:mah]
synonym: "ferric ion import" EXACT []
synonym: "ferric iron uptake" EXACT []
is_a: GO:0015682 ! ferric iron transport

[Term]
id: GO:0033217
name: regulation of transcription from RNA polymerase II promoter in response to iron ion starvation
namespace: biological_process
def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of iron ions." [GOC:mah]
synonym: "regulation of transcription from RNA polymerase II promoter in response to iron deficiency" EXACT []
is_a: GO:0010106 ! cellular response to iron ion starvation
is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress

[Term]
id: GO:0033218
name: amide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [ChEBI:32988, GOC:mah]
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0033219
name: urea binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with urea, a water-soluble carboxamide with the structure H2N-CO-NH2." [ChEBI:16199, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0033218 ! amide binding

[Term]
id: GO:0033220
name: amide-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + amide(out) = ADP + phosphate + amide(in)." [GOC:mah]
subset: gosubset_prok
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances
is_a: GO:0042887 ! amide transmembrane transporter activity

[Term]
id: GO:0033221
name: urea-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in)." [GOC:mlg]
subset: gosubset_prok
synonym: "carbamide-transporting ATPase activity" EXACT []
is_a: GO:0015204 ! urea transmembrane transporter activity
is_a: GO:0033220 ! amide-transporting ATPase activity

[Term]
id: GO:0033222
name: xylose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the D- or L-enantiomer of xylose." [ChEBI:18222, GOC:mah]
subset: gosubset_prok
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0033223
name: 2-aminoethylphosphonate transport
namespace: biological_process
def: "The directed movement of 2-aminoethylphosphonate, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mlg]
synonym: "2-phosphonoethylamine transport" EXACT []
synonym: "ciliatine transport" EXACT []
is_a: GO:0015716 ! phosphonate transport
is_a: GO:0015837 ! amine transport

[Term]
id: GO:0033224
name: 2-aminoethylphosphonate transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of 2-aminoethylphosphonate into, out of, within or between cells." [GOC:mlg]
synonym: "2-phosphonoethylamine transmembrane transporter activity" EXACT []
synonym: "ciliatine transporter activity" EXACT []
is_a: GO:0005275 ! amine transmembrane transporter activity

[Term]
id: GO:0033225
name: 2-aminoethylphosphonate transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + 2-aminoethylphosphonate(out) = ADP + phosphate + 2-aminoethylphosphonate(in)." [GOC:mlg]
synonym: "2-phosphonoethylamine transporting ATPase activity" EXACT []
synonym: "ciliatine transportingATPase activity" EXACT []
is_a: GO:0031263 ! amine-transporting ATPase activity
is_a: GO:0033224 ! 2-aminoethylphosphonate transmembrane transporter activity

[Term]
id: GO:0033226
name: 2-aminoethylphosphonate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 2-aminoethylphosphonate." [GOC:mlg]
synonym: "2-phosphonoethylamine binding" EXACT []
synonym: "ciliatine binding" EXACT []
is_a: GO:0043176 ! amine binding

[Term]
id: GO:0033227
name: dsRNA transport
namespace: biological_process
def: "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:0033228
name: cysteine export
namespace: biological_process
def: "The directed movement of cysteine out of a cell or organelle." [GOC:mlg]
is_a: GO:0032973 ! amino acid export
is_a: GO:0042883 ! cysteine transport

[Term]
id: GO:0033229
name: cysteine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of cysteine from one side of the membrane to the other." [GOC:mah]
is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity

[Term]
id: GO:0033230
name: cysteine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(out/in) = ADP + phosphate + cysteine(in/out)." [GOC:mlg]
is_a: GO:0015424 ! amino acid-transporting ATPase activity
is_a: GO:0033229 ! cysteine transmembrane transporter activity

[Term]
id: GO:0033231
name: carbohydrate export
namespace: biological_process
def: "The directed movement of carbohydrates out of a cell or organelle." [GOC:mlg]
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0033232
name: D-methionine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out)." [GOC:mlg]
is_a: GO:0015424 ! amino acid-transporting ATPase activity
is_a: GO:0048474 ! D-methionine transmembrane transporter activity

[Term]
id: GO:0033233
name: regulation of protein sumoylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of SUMO moieties to a protein." [GOC:mah]
synonym: "regulation of sumoylation" EXACT []
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0016925 ! protein sumoylation

[Term]
id: GO:0033234
name: negative regulation of protein sumoylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the addition of SUMO moieties to a protein." [GOC:mah]
synonym: "negative regulation of sumoylation" EXACT []
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0033233 ! regulation of protein sumoylation
relationship: negatively_regulates GO:0016925 ! protein sumoylation

[Term]
id: GO:0033235
name: positive regulation of protein sumoylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of SUMO moieties to a protein." [GOC:mah]
synonym: "positive regulation of sumoylation" EXACT []
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0033233 ! regulation of protein sumoylation
relationship: positively_regulates GO:0016925 ! protein sumoylation

[Term]
id: GO:0033236
name: 11-beta-hydroxysteroid dehydrogenase (NAD+) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+." [PMID:15761036]
is_obsolete: true
replaced_by: GO:0070523

[Term]
id: GO:0033237
name: 11-beta-hydroxysteroid dehydrogenase (NADP+) activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [EC:1.1.1.146]
synonym: "11beta-hydroxysteroid:NADP+ 11-oxidoreductase" EXACT [EC:1.1.1.146]
synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146]
synonym: "corticosteroid 11-beta-dehydrogenase activity" EXACT [EC:1.1.1.146]
xref: EC:1.1.1.146
xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN
is_obsolete: true
replaced_by: GO:0070524

[Term]
id: GO:0033238
name: regulation of cellular amine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of amine metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
relationship: regulates GO:0044106 ! cellular amine metabolic process

[Term]
id: GO:0033239
name: negative regulation of cellular amine metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah]
synonym: "negative regulation of amine metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
relationship: negatively_regulates GO:0044106 ! cellular amine metabolic process

[Term]
id: GO:0033240
name: positive regulation of cellular amine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah]
synonym: "positive regulation of amine metabolism" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
relationship: positively_regulates GO:0044106 ! cellular amine metabolic process

[Term]
id: GO:0033241
name: regulation of cellular amine catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah]
synonym: "regulation of amine breakdown" EXACT []
synonym: "regulation of amine catabolism" EXACT []
synonym: "regulation of amine degradation" EXACT []
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0033238 ! regulation of cellular amine metabolic process
relationship: regulates GO:0009310 ! amine catabolic process

[Term]
id: GO:0033242
name: negative regulation of cellular amine catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah]
synonym: "negative regulation of amine breakdown" EXACT []
synonym: "negative regulation of amine catabolism" EXACT []
synonym: "negative regulation of amine degradation" EXACT []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0033239 ! negative regulation of cellular amine metabolic process
is_a: GO:0033241 ! regulation of cellular amine catabolic process
relationship: negatively_regulates GO:0009310 ! amine catabolic process

[Term]
id: GO:0033243
name: positive regulation of cellular amine catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah]
synonym: "positive regulation of amine breakdown" EXACT []
synonym: "positive regulation of amine catabolism" EXACT []
synonym: "positive regulation of amine degradation" EXACT []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0033240 ! positive regulation of cellular amine metabolic process
is_a: GO:0033241 ! regulation of cellular amine catabolic process
relationship: positively_regulates GO:0009310 ! amine catabolic process

[Term]
id: GO:0033244
name: regulation of penicillin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "regulation of penicillin metabolism" EXACT []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
relationship: regulates GO:0042316 ! penicillin metabolic process

[Term]
id: GO:0033245
name: negative regulation of penicillin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "negative regulation of penicillin metabolism" EXACT []
is_a: GO:0033239 ! negative regulation of cellular amine metabolic process
is_a: GO:0033244 ! regulation of penicillin metabolic process
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
relationship: negatively_regulates GO:0042316 ! penicillin metabolic process

[Term]
id: GO:0033246
name: positive regulation of penicillin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "positive regulation of penicillin metabolism" EXACT []
is_a: GO:0033240 ! positive regulation of cellular amine metabolic process
is_a: GO:0033244 ! regulation of penicillin metabolic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
relationship: positively_regulates GO:0042316 ! penicillin metabolic process

[Term]
id: GO:0033247
name: regulation of penicillin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "regulation of penicillin breakdown" EXACT []
synonym: "regulation of penicillin catabolism" EXACT []
synonym: "regulation of penicillin degradation" EXACT []
is_a: GO:0033244 ! regulation of penicillin metabolic process
is_a: GO:0034251 ! regulation of cellular amide catabolic process
relationship: regulates GO:0042317 ! penicillin catabolic process

[Term]
id: GO:0033248
name: negative regulation of penicillin catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "negative regulation of penicillin breakdown" EXACT []
synonym: "negative regulation of penicillin catabolism" EXACT []
synonym: "negative regulation of penicillin degradation" EXACT []
is_a: GO:0033245 ! negative regulation of penicillin metabolic process
is_a: GO:0033247 ! regulation of penicillin catabolic process
is_a: GO:0034252 ! negative regulation of cellular amide catabolic process
relationship: negatively_regulates GO:0042317 ! penicillin catabolic process

[Term]
id: GO:0033249
name: positive regulation of penicillin catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah]
synonym: "positive regulation of penicillin breakdown" EXACT []
synonym: "positive regulation of penicillin catabolism" EXACT []
synonym: "positive regulation of penicillin degradation" EXACT []
is_a: GO:0033246 ! positive regulation of penicillin metabolic process
is_a: GO:0033247 ! regulation of penicillin catabolic process
is_a: GO:0034253 ! positive regulation of cellular amide catabolic process
relationship: positively_regulates GO:0042317 ! penicillin catabolic process

[Term]
id: GO:0033250
name: penicillinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a penicillin + H2O = a substituted beta-amino acid derivative of the penicillin." [GOC:mlg]
xref: MetaCyc:BETA-LACTAMASE-RXN
is_a: GO:0008800 ! beta-lactamase activity

[Term]
id: GO:0033251
name: cephalosporinase activity
namespace: molecular_function
def: "Catalysis of the reaction: a cephalosporin + H2O = a substituted beta-amino acid derivative of the cephalosporin." [GOC:mlg]
xref: MetaCyc:BETA-LACTAMASE-RXN
is_a: GO:0008800 ! beta-lactamase activity

[Term]
id: GO:0033252
name: regulation of beta-lactamase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of beta-lactamase activity, the hydrolysis of a beta-lactam to yield a substituted beta-amino acid." [GOC:mah]
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0033253
name: regulation of penicillinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of a penicillin to yield a substituted beta-amino acid derivative." [GOC:mah]
is_a: GO:0033252 ! regulation of beta-lactamase activity

[Term]
id: GO:0033254
name: vacuolar transporter chaperone complex
namespace: cellular_component
def: "A protein complex that contains four related proteins that have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. The complex is enriched at the vacuolar membrane, but also found in other cellular compartments, including the ER and the cell periphery. In Saccharomyces, the subunits are Vtc1p, Vtc2p, Vtc3p and Vtc4p." [PMID:11823419, PMID:17079729]
synonym: "VTC complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0033255
name: SAS acetyltransferase complex
namespace: cellular_component
def: "A protein complex that possesses histone acetyltransferase activity and links histone acetylation to the assembly of transcriptionally silent chromatin. In vitro, the complex acetylates lysine 16 of histone H4 and lysine 14 of histone H3, although the latter may not be relevant in vivo. The complex contains a catalytic subunit and at least two other subunits; in Saccharomyces, the catalytic subunit is Sas2p and additional subunits are Sas4p and Sas5p." [PMID:11731480, PMID:12626510, PMID:15788653]
synonym: "SAS-I complex" EXACT []
is_a: GO:0032777 ! Piccolo NuA4 histone acetyltransferase complex

[Term]
id: GO:0033256
name: I-kappaB/NF-kappaB complex
namespace: cellular_component
def: "A protein complex containing an I-kappaB protein and one or more copies of an NF-kappaB protein; mediates regulation of NF-kappaB activity by I-kappaB." [GOC:mah, PMID:9407099]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0033257
name: Bcl3/NF-kappaB2 complex
namespace: cellular_component
def: "A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription." [GOC:mah, PMID:9407099]
synonym: "Bcl3-NFKB2 complex" RELATED []
synonym: "Bcl3-p52 complex" EXACT []
is_a: GO:0033256 ! I-kappaB/NF-kappaB complex

[Term]
id: GO:0033258
name: plastid DNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving plastid DNA." [GOC:mah]
synonym: "plastid DNA metabolism" EXACT []
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0009657 ! plastid organization

[Term]
id: GO:0033259
name: plastid DNA replication
namespace: biological_process
def: "The process whereby new strands of DNA are synthesized in a plastid." [GOC:mah]
synonym: "plastid DNA synthesis" RELATED []
synonym: "replication of plastid DNA" EXACT []
is_a: GO:0006261 ! DNA-dependent DNA replication
is_a: GO:0033258 ! plastid DNA metabolic process

[Term]
id: GO:0033260
name: DNA replication during S phase
namespace: biological_process
def: "The process whereby new strands of genomic DNA are synthesized, using parental DNA as a template for DNA-dependent DNA polymerases, during progression through S phase of the cell cycle." [GOC:mah]
is_a: GO:0006261 ! DNA-dependent DNA replication
relationship: part_of GO:0051320 ! S phase

[Term]
id: GO:0033261
name: regulation of S phase
namespace: biological_process
def: "A cell cycle process that modulates the rate or extent of the progression through the S phase of the cell cycle." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of progression through S phase" EXACT [GOC:dph, GOC:tb]
xref: MetaCyc:PWY-5043
xref: MetaCyc:SALVADEHYPOX-PWY
xref: MetaCyc:SALVPURINE2-PWY
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0051320 ! S phase

[Term]
id: GO:0033262
name: regulation of DNA replication during S phase
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA replication during progression through S phase of the cell cycle." [GOC:mah]
is_a: GO:0006275 ! regulation of DNA replication
is_a: GO:0033261 ! regulation of S phase
relationship: regulates GO:0033260 ! DNA replication during S phase

[Term]
id: GO:0033263
name: CORVET complex
namespace: cellular_component
def: "A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625]
is_a: GO:0043234 ! protein complex
is_a: GO:0044440 ! endosomal part

[Term]
id: GO:0033264
name: bontoxilysin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates." [EC:3.4.24.69]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "BoNT" RELATED [EC:3.4.24.69]
synonym: "botulinum neurotoxin activity" EXACT []
xref: EC:3.4.24.69
xref: MetaCyc:3.4.24.69-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0033265
name: choline binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium." [ChEBI:15354, GOC:mlg]
is_a: GO:0043169 ! cation binding
is_a: GO:0043176 ! amine binding
is_a: GO:0043178 ! alcohol binding
is_a: GO:0050997 ! quaternary ammonium group binding

[Term]
id: GO:0033266
name: choline-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of choline across a membrane." [GOC:mlg]
is_a: GO:0015220 ! choline transmembrane transporter activity
is_a: GO:0031263 ! amine-transporting ATPase activity

[Term]
id: GO:0033267
name: axon part
namespace: cellular_component
def: "A part of an axon, a cell projection of a neuron." [GOC:jl]
xref: NIF_Subcellular:sao280355188
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0030424 ! axon

[Term]
id: GO:0033268
name: node of Ranvier
namespace: cellular_component
def: "An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed." [GOC:mh]
xref: NIF_Subcellular:birnlex_1152_2
xref: Wikipedia:Nodes_of_Ranvier
is_a: GO:0033267 ! axon part
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0033269
name: internode region of axon
namespace: cellular_component
def: "An axon part that is located between the nodes of Ranvier and surrounded by compact myelin sheath." [GOC:mah, GOC:mh]
synonym: "internode" EXACT []
xref: NIF_Subcellular:sao206157942
is_a: GO:0033267 ! axon part
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0033270
name: paranode region of axon
namespace: cellular_component
def: "An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath." [GOC:mah, GOC:mh]
synonym: "paranode" EXACT []
xref: NIF_Subcellular:sao234066064
is_a: GO:0033267 ! axon part
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0033271
name: myo-inositol phosphate transport
namespace: biological_process
def: "The directed movement of any phosphorylated myo-inositol into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0015798 ! myo-inositol transport

[Term]
id: GO:0033272
name: myo-inositol hexakisphosphate transport
namespace: biological_process
def: "The directed movement of myo-inositol hexakisphosphate into, out of, within or between cells by means of some external agent such as a transporter or pore." [ChEBI:17401, GOC:mah]
synonym: "phytate transport" EXACT []
is_a: GO:0033271 ! myo-inositol phosphate transport

[Term]
id: GO:0033273
name: response to vitamin
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus." [GOC:sl]
is_a: GO:0007584 ! response to nutrient

[Term]
id: GO:0033274
name: response to vitamin B2
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus." [GOC:sl]
synonym: "response to riboflavin" EXACT []
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0033275
name: actin-myosin filament sliding
namespace: biological_process
def: "The sliding movement of actin thin filaments and myosin thick filaments past each other." [GOC:pf]
synonym: "actin filament sliding" RELATED []
is_a: GO:0030048 ! actin filament-based movement
is_a: GO:0070252 ! actin-mediated cell contraction

[Term]
id: GO:0033276
name: transcription factor TFTC complex
namespace: cellular_component
def: "A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity." [PMID:10373431, PMID:9603525]
is_a: GO:0005667 ! transcription factor complex
is_a: GO:0070461 ! SAGA-type complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0033277
name: abortive mitotic cell cycle
namespace: biological_process
def: "A cell cycle in which mitosis is begun and progresses normally through the end of anaphase, but not completed, resulting in a cell with increased ploidy." [GOC:mah, PMID:9573008]
comment: Note that this term should be used only for abortive mitotic events that occur normally, e.g. during megakaryocyte differentiation; it should not be used for incomplete mitosis resulting from mutation or other abnormal occurrences.
synonym: "abortive mitosis" RELATED []
is_a: GO:0007049 ! cell cycle

[Term]
id: GO:0033278
name: cell proliferation in midbrain
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain." [GO_REF:0000021, GOC:df]
comment: This term was added by GO_REF:0000021.
synonym: "cell proliferation in mesencephalon" EXACT []
synonym: "mesencepahalic cell proliferation" RELATED []
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0030901 ! midbrain development

[Term]
id: GO:0033279
name: ribosomal subunit
namespace: cellular_component
def: "Either of the two ribonucleoprotein complexes that associate to form a ribosome." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005840 ! ribosome

[Term]
id: GO:0033280
name: response to vitamin D
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus." [GOC:sl]
synonym: "response to calciferol" EXACT []
synonym: "response to cholecalciferol" NARROW []
synonym: "response to ergocalciferol" NARROW []
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0033281
name: TAT protein transport complex
namespace: cellular_component
def: "A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins." [GOC:pamgo_curators]
subset: gosubset_prok
synonym: "TAT protein secretion complex" NARROW []
synonym: "TAT protein translocation system complex" NARROW []
synonym: "Twin-arginine translocation complex " NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0033282
name: protein C inhibitor-acrosin complex
namespace: cellular_component
def: "A heterodimeric protein complex of protein C inhibitor and acrosin; complex formation inhibits the protease activity of acrosin." [PMID:11120760, PMID:7521127]
synonym: "PCI-ACR complex" EXACT []
synonym: "PCI-acrosin complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0002080 ! acrosomal membrane

[Term]
id: GO:0033283
name: organic acid-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out)." [GOC:mlg]
is_a: GO:0005342 ! organic acid transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0033284
name: carboxylic acid-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carboxylic acid(out/in) = ADP + phosphate + carboxylic acid(in/out)." [GOC:mlg]
is_a: GO:0033283 ! organic acid-transporting ATPase activity
is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity

[Term]
id: GO:0033285
name: monocarboxylic acid-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monocarboxylic acid(out/in) = ADP + phosphate + monocarboxylic acid(in/out)." [GOC:mlg]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity
is_a: GO:0033284 ! carboxylic acid-transporting ATPase activity

[Term]
id: GO:0033286
name: ectoine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ectoine(out/in) = ADP + phosphate + ectoine(in/out)." [GOC:mlg]
is_a: GO:0033285 ! monocarboxylic acid-transporting ATPase activity
is_a: GO:0051471 ! ectoine transmembrane transporter activity

[Term]
id: GO:0033287
name: hydroxyectoine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of hydroxyectoine from one side of the membrane to the other." [GOC:mlg]
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0033288
name: hydroxyectoine-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out)." [GOC:mlg]
is_a: GO:0033285 ! monocarboxylic acid-transporting ATPase activity
is_a: GO:0033287 ! hydroxyectoine transmembrane transporter activity

[Term]
id: GO:0033289
name: intraconoid microtubule
namespace: cellular_component
def: "A microtubule located such that it threads through the conoid and projects through the polar ring." [GOC:mah, PMID:11901169, PMID:16518471]
is_a: GO:0005874 ! microtubule
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0033290
name: eukaryotic 48S preinitiation complex
namespace: cellular_component
alt_id: GO:0016283
def: "A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049]
synonym: "eukaryotic 48S initiation complex" RELATED []
synonym: "eukaryotic 48S pre-initiation complex" EXACT []
is_a: GO:0070993 ! translation preinitiation complex

[Term]
id: GO:0033291
name: eukaryotic 80S initiation complex
namespace: cellular_component
def: "A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region." [GOC:hjd, PMID:15145049]
is_a: GO:0070992 ! translation initiation complex

[Term]
id: GO:0033292
name: T-tubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril." [GOC:dph, GOC:jl, GOC:mah]
synonym: "T-tubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016044 ! cellular membrane organization
relationship: part_of GO:0007009 ! plasma membrane organization
relationship: part_of GO:0055001 ! muscle cell development

[Term]
id: GO:0033293
name: monocarboxylic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:mah]
subset: gosubset_prok
is_a: GO:0031406 ! carboxylic acid binding

[Term]
id: GO:0033294
name: ectoine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid." [GOC:mah]
is_a: GO:0033293 ! monocarboxylic acid binding

[Term]
id: GO:0033295
name: hydroxyectoine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with hydroxyectoine." [GOC:mlg]
is_a: GO:0033293 ! monocarboxylic acid binding

[Term]
id: GO:0033296
name: rhamnose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the D- or L-enantiomer of rhamnose." [ChEBI:26546, GOC:mah]
subset: gosubset_prok
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0033297
name: rhamnose-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + rhamnose(out/in) = ADP + phosphate + rhamnose(in/out)." [GOC:mlg]
is_a: GO:0015153 ! rhamnose transmembrane transporter activity
is_a: GO:0015407 ! monosaccharide-transporting ATPase activity

[Term]
id: GO:0033298
name: contractile vacuole organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a contractile vacuole. A specialized vacuole that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores." [GOC:mah]
synonym: "contractile vacuole organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007033 ! vacuole organization
is_a: GO:0016050 ! vesicle organization

[Term]
id: GO:0033299
name: secretion of lysosomal enzymes
namespace: biological_process
def: "The controlled release of lysosomal enzymes by a cell or group of cells." [GOC:mah]
is_a: GO:0009306 ! protein secretion

[Term]
id: GO:0033300
name: dehydroascorbic acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, into, out of, within or between cells by means of some external agent such as a transporter or pore." [ChEBI:17242]
synonym: "dehydroascorbate transporter activity" EXACT []
xref: Reactome:198811 "dehydroascorbic acid transporter activity"
is_a: GO:0051183 ! vitamin transporter activity

[Term]
id: GO:0033301
name: cell cycle comprising mitosis without cytokinesis
namespace: biological_process
def: "A mitotic cell cycle in which mitosis is completed but cytokinesis does not occur, resulting in a cell containing multiple nuclei each with a chromosomal complement of the original ploidy (usually 2N)." [GOC:expert_vm, GOC:mah]
comment: Note that this term should be used for naturally occurring instances of mitosis without cytokinesis, e.g. in the tapetum of flowers and in a number of lower eukaryotes; it should not be used for abnormal events such as may occur in cancers.
is_a: GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0033302
name: quercetin O-glucoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving O-glucosylated derivatives of quercetin." [ChEBI:28299, ChEBI:28529, GOC:mah, MetaCyc:PWY-5321]
synonym: "quercetin O-glucoside metabolism" EXACT []
is_a: GO:0016140 ! O-glycoside metabolic process

[Term]
id: GO:0033303
name: quercetin O-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of quercetin." [ChEBI:28299, ChEBI:28529, GOC:mah, MetaCyc:PWY-5321]
synonym: "quercetin O-glucoside anabolism" EXACT []
synonym: "quercetin O-glucoside biosynthesis" EXACT []
synonym: "quercetin O-glucoside formation" EXACT []
synonym: "quercetin O-glucoside synthesit" EXACT []
xref: MetaCyc:PWY-5321
is_a: GO:0016141 ! O-glycoside biosynthetic process
is_a: GO:0033302 ! quercetin O-glucoside metabolic process

[Term]
id: GO:0033304
name: chlorophyll a metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chlorophyll a." [ChEBI:18230, GOC:mah]
subset: gosubset_prok
synonym: "chlorophyll a metabolism" EXACT []
is_a: GO:0015994 ! chlorophyll metabolic process

[Term]
id: GO:0033305
name: chlorophyll a biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of chlorophyll a." [ChEBI:18230, GOC:mah]
subset: gosubset_prok
synonym: "chlorophyll a anabolism" EXACT []
synonym: "chlorophyll a biosynthesis" EXACT []
synonym: "chlorophyll a formation" EXACT []
synonym: "chlorophyll a synthesis" EXACT []
is_a: GO:0015995 ! chlorophyll biosynthetic process
is_a: GO:0033304 ! chlorophyll a metabolic process

[Term]
id: GO:0033306
name: phytol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [ChEBI:17327, GOC:mah]
synonym: "phytol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process

[Term]
id: GO:0033307
name: phytol salvage
namespace: biological_process
def: "A process that generates phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol, from derivatives of it without de novo synthesis." [GOC:mah, MetaCyc:PWY-5107]
synonym: "phytol salvage pathway" EXACT []
xref: MetaCyc:PWY-5107
is_a: GO:0033520 ! phytol biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0033308
name: hydroxyectoine transport
namespace: biological_process
def: "The directed movement of hydroxyectoine into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0033309
name: SBF transcription complex
namespace: cellular_component
def: "A protein complex that binds to the Swi4/6 cell cycle box (SCB) promoter element, consensus sequence CRCGAAA, and activates transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Swi6p and the activator Swi4p, and is associated with additional proteins known as Whi5p and Msa1p." [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:7917338]
synonym: "SBF complex" EXACT [GOC:mah]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0033310
name: chlorophyll a catabolic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the breakdown of chlorophyll a." [ChEBI:18230, GOC:mah]
subset: gosubset_prok
synonym: "chlorophyll a breakdown" EXACT []
synonym: "chlorophyll a catabolism" EXACT []
synonym: "chlorophyll a degradation" EXACT []
xref: MetaCyc:PWY-5086
xref: MetaCyc:PWY-5098
is_a: GO:0015996 ! chlorophyll catabolic process
is_a: GO:0033304 ! chlorophyll a metabolic process

[Term]
id: GO:0033311
name: chlorophyll a biosynthetic process via phytyl diphosphate
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate phytyl diphosphate." [ChEBI:18230, GOC:mah, MetaCyc:PWY-5086]
subset: gosubset_prok
synonym: "chlorophyll a anabolism via phytyl diphosphate" EXACT []
synonym: "chlorophyll a biosynthesis via phytyl diphosphate" EXACT []
synonym: "chlorophyll a biosynthetic process via phytyl-PP" EXACT []
synonym: "chlorophyll a formation via phytyl chlorophyll a formation via phytyl-PP" EXACT []
synonym: "chlorophyll a synthesis via phytyl diphosphate" EXACT []
xref: MetaCyc:PWY-5086
is_a: GO:0033305 ! chlorophyll a biosynthetic process

[Term]
id: GO:0033312
name: chlorophyll a biosynthetic process via geranylgeranyl-chlorophyll a
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate geranylgeranyl-chlorophyll a." [ChEBI:18230, GOC:mah, MetaCyc:PWY-5064]
subset: gosubset_prok
synonym: "chlorophyll a anabolism via geranylgeranyl-chlorophyll a" EXACT []
synonym: "chlorophyll a biosynthesis via geranylgeranyl-chlorophyll a" EXACT []
synonym: "chlorophyll a formation via geranylgeranyl-chlorophyll a" EXACT []
synonym: "chlorophyll a synthesis via geranylgeranyl-chlorophyll a" EXACT []
xref: MetaCyc:PWY-5064
is_a: GO:0033305 ! chlorophyll a biosynthetic process

[Term]
id: GO:0033313
name: meiotic cell cycle checkpoint
namespace: biological_process
def: "A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a meiotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mah]
is_a: GO:0000075 ! cell cycle checkpoint
is_a: GO:0051445 ! regulation of meiotic cell cycle

[Term]
id: GO:0033314
name: mitotic cell cycle DNA replication checkpoint
namespace: biological_process
def: "A signal transduction based surveillance mechanism that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:mah]
is_a: GO:0000076 ! DNA replication checkpoint
is_a: GO:0007093 ! mitotic cell cycle checkpoint

[Term]
id: GO:0033315
name: meiotic cell cycle DNA replication checkpoint
namespace: biological_process
def: "A signal transduction based surveillance mechanism that acts during a meiotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the haploid genome." [GOC:mah]
is_a: GO:0000076 ! DNA replication checkpoint
is_a: GO:0033313 ! meiotic cell cycle checkpoint

[Term]
id: GO:0033316
name: meiotic spindle checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah]
is_a: GO:0071173 ! spindle assembly checkpoint

[Term]
id: GO:0033317
name: pantothenate biosynthetic process from valine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid, from other compounds, including valine." [GOC:mah, MetaCyc:PANTO-PWY, MetaCyc:PWY-3921]
synonym: "pantothenate anabolism from valine" EXACT []
synonym: "pantothenate biosynthesis from valine" EXACT []
synonym: "pantothenate formation from valine" EXACT []
synonym: "pantothenate synthesis from valine" EXACT []
xref: MetaCyc:PANTO-PWY
is_a: GO:0015940 ! pantothenate biosynthetic process

[Term]
id: GO:0033318
name: pantothenate biosynthetic process from 2-oxypantoyl lactone
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid, from other compounds, including 2-oxypantoyl lactone." [GOC:mah, MetaCyc:PWY-3961]
synonym: "pantothenate anabolism from 2-oxypantoyl lactone" EXACT []
synonym: "pantothenate biosynthesis from 2-oxypantoyl lactone" EXACT []
synonym: "pantothenate formation from 2-oxypantoyl lactone" EXACT []
synonym: "pantothenate synthesis from 2-oxypantoyl lactone" EXACT []
xref: MetaCyc:PWY-3961
is_a: GO:0015940 ! pantothenate biosynthetic process

[Term]
id: GO:0033319
name: UDP-D-xylose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:mah]
synonym: "UDP-D-xylose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:0042732 ! D-xylose metabolic process

[Term]
id: GO:0033320
name: UDP-D-xylose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-4821]
synonym: "UDP-D-xylose anabolism" EXACT []
synonym: "UDP-D-xylose biosynthesis" EXACT []
synonym: "UDP-D-xylose formation" EXACT []
synonym: "UDP-D-xylose synthesis" EXACT []
xref: MetaCyc:PWY-4821
is_a: GO:0033319 ! UDP-D-xylose metabolic process
is_a: GO:0042842 ! D-xylose biosynthetic process

[Term]
id: GO:0033321
name: homomethionine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186]
synonym: "homomethionine metabolism" EXACT []
is_a: GO:0000096 ! sulfur amino acid metabolic process

[Term]
id: GO:0033322
name: homomethionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186]
synonym: "homomethionine anabolism" EXACT []
synonym: "homomethionine biosynthesis" EXACT []
synonym: "homomethionine formation" EXACT []
synonym: "homomethionine synthesis" EXACT []
xref: MetaCyc:PWY-1186
is_a: GO:0000097 ! sulfur amino acid biosynthetic process
is_a: GO:0033321 ! homomethionine metabolic process

[Term]
id: GO:0033323
name: choline biosynthetic process via CDP-choline
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate CDP-choline." [GOC:mah, MetaCyc:PWY-3561]
subset: gosubset_prok
synonym: "choline anabolism via CDP-choline" EXACT []
synonym: "choline biosynthesis via CDP-choline" EXACT []
synonym: "choline formation via CDP-choline" EXACT []
synonym: "choline synthesis via CDP-choline" EXACT []
xref: MetaCyc:PWY-3561
xref: MetaCyc:PWY-4762
is_a: GO:0042425 ! choline biosynthetic process

[Term]
id: GO:0033324
name: choline biosynthetic process via N-monomethylethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate N-monomethylethanolamine." [GOC:mah, MetaCyc:PWY-3542]
subset: gosubset_prok
synonym: "choline anabolism via N-monomethylethanolamine" EXACT []
synonym: "choline biosynthesis via N-monomethylethanolamine" EXACT []
synonym: "choline formation via N-monomethylethanolamine" EXACT []
synonym: "choline synthesis via N-monomethylethanolamine" EXACT []
xref: MetaCyc:PWY-3542
xref: MetaCyc:PWY-4762
is_a: GO:0042425 ! choline biosynthetic process

[Term]
id: GO:0033325
name: choline biosynthetic process via phosphoryl-ethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate phosphoryl-ethanolamine." [GOC:mah, MetaCyc:PWY-3385]
subset: gosubset_prok
synonym: "choline anabolism via phosphoryl-ethanolamine" EXACT []
synonym: "choline biosynthesis via phosphoryl-ethanolamine" EXACT []
synonym: "choline formation via phosphoryl-ethanolamine" EXACT []
synonym: "choline synthesis via phosphoryl-ethanolamine" EXACT []
xref: MetaCyc:PWY-3385
xref: MetaCyc:PWY-4762
is_a: GO:0042425 ! choline biosynthetic process

[Term]
id: GO:0033326
name: cerebrospinal fluid secretion
namespace: biological_process
def: "The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces." [GOC:ln, http://users.ahsc.arizona.edu/davis/csf.htm, PMID:10716451]
synonym: "CSF secretion" EXACT []
is_a: GO:0007589 ! body fluid secretion

[Term]
id: GO:0033327
name: Leydig cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [GOC:ln, PMID:12050120]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0008584 ! male gonad development

[Term]
id: GO:0033328
name: peroxisome membrane targeting sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane." [GOC:rb, PMID:15133130]
synonym: "mPTS binding" EXACT []
is_a: GO:0000268 ! peroxisome targeting sequence binding

[Term]
id: GO:0033329
name: kaempferol O-glucoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol." [ChEBI:30200, GOC:mah, MetaCyc:PWY-5320]
synonym: "kaempferol O-glucoside metabolism" EXACT []
is_a: GO:0016140 ! O-glycoside metabolic process

[Term]
id: GO:0033330
name: kaempferol O-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of kaempferol." [ChEBI:30200, GOC:mah, MetaCyc:PWY-5320]
synonym: "kaempferol O-glucoside anabolism" EXACT []
synonym: "kaempferol O-glucoside biosynthesis" EXACT []
synonym: "kaempferol O-glucoside formation" EXACT []
synonym: "kaempferol O-glucoside synthesit" EXACT []
xref: MetaCyc:PWY-5320
is_a: GO:0016141 ! O-glycoside biosynthetic process
is_a: GO:0033329 ! kaempferol O-glucoside metabolic process

[Term]
id: GO:0033331
name: ent-kaurene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, MetaCyc:PWY-5032, PMID:17064690]
subset: gosubset_prok
synonym: "ent-kaurene metabolism" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process

[Term]
id: GO:0033332
name: ent-kaurene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ent-kaurene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, MetaCyc:PWY-5032, PMID:17064690]
subset: gosubset_prok
synonym: "ent-kaurene anabolism" EXACT []
synonym: "ent-kaurene biosynthesis" EXACT []
synonym: "ent-kaurene formation" EXACT []
synonym: "ent-kaurene synthesis" EXACT []
xref: MetaCyc:PWY-5032
xref: MetaCyc:PWY-5035
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:0033331 ! ent-kaurene metabolic process

[Term]
id: GO:0033333
name: fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of a fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0048736 ! appendage development

[Term]
id: GO:0033334
name: fin morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a fin are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dgh]
is_a: GO:0035107 ! appendage morphogenesis
relationship: part_of GO:0033333 ! fin development

[Term]
id: GO:0033335
name: anal fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anal fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033338 ! medial fin development

[Term]
id: GO:0033336
name: caudal fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the caudal fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033338 ! medial fin development

[Term]
id: GO:0033337
name: dorsal fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dorsal fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033338 ! medial fin development

[Term]
id: GO:0033338
name: medial fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of a medial fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033333 ! fin development

[Term]
id: GO:0033339
name: pectoral fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033333 ! fin development

[Term]
id: GO:0033340
name: pelvic fin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pelvic fin over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0033333 ! fin development

[Term]
id: GO:0033341
name: regulation of collagen binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collagen binding." [GOC:mah]
is_a: GO:0043393 ! regulation of protein binding

[Term]
id: GO:0033342
name: negative regulation of collagen binding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of collagen binding." [GOC:mah]
synonym: "down regulation of collagen binding" EXACT []
synonym: "down-regulation of collagen binding" EXACT []
synonym: "downregulation of collagen binding" EXACT []
synonym: "inhibition of collagen binding" NARROW []
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:0033341 ! regulation of collagen binding

[Term]
id: GO:0033343
name: positive regulation of collagen binding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collagen binding." [GOC:mah]
synonym: "activation of collagen binding" NARROW []
synonym: "stimulation of collagen binding" NARROW []
synonym: "up regulation of collagen binding" EXACT []
synonym: "up-regulation of collagen binding" EXACT []
synonym: "upregulation of collagen binding" EXACT []
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:0033341 ! regulation of collagen binding

[Term]
id: GO:0033344
name: cholesterol efflux
namespace: biological_process
def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:sart]
synonym: "cholesterol export" EXACT []
is_a: GO:0030301 ! cholesterol transport

[Term]
id: GO:0033345
name: asparagine catabolic process via L-aspartate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah]
xref: MetaCyc:ASPARAGINE-DEG1-PWY
is_a: GO:0006530 ! asparagine catabolic process

[Term]
id: GO:0033346
name: asparagine catabolic process via 2-oxosuccinamate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxosuccinamate." [GOC:mah, MetaCyc:PWY-4002]
xref: MetaCyc:PWY-4002
is_a: GO:0006530 ! asparagine catabolic process

[Term]
id: GO:0033347
name: tetrose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule." [GOC:mah]
subset: gosubset_prok
synonym: "tetrose metabolism" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process

[Term]
id: GO:0033348
name: tetrose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule." [GOC:mah]
synonym: "tetrose anabolism" EXACT []
synonym: "tetrose biosynthesis" EXACT []
synonym: "tetrose formation" EXACT []
synonym: "tetrose synthesis" EXACT []
is_a: GO:0033347 ! tetrose metabolic process
is_a: GO:0046364 ! monosaccharide biosynthetic process

[Term]
id: GO:0033349
name: apiose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose." [ChEBI:16689, GOC:mah]
synonym: "apiose metabolism" EXACT []
is_a: GO:0033347 ! tetrose metabolic process

[Term]
id: GO:0033350
name: apiose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose." [ChEBI:16689, GOC:mah]
synonym: "apiose anabolism" EXACT []
synonym: "apiose biosynthesis" EXACT []
synonym: "apiose formation" EXACT []
synonym: "apiose synthesis" EXACT []
is_a: GO:0033348 ! tetrose biosynthetic process
is_a: GO:0033349 ! apiose metabolic process

[Term]
id: GO:0033351
name: UDP-D-apiose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-D-apiose, uridinediphosphoapiose, a substance composed of apiose in glycosidic linkage with uridine diphosphate." [GOC:mah]
synonym: "UDP-D-apiose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:0033349 ! apiose metabolic process

[Term]
id: GO:0033352
name: UDP-D-apiose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-D-apiose, uridinediphosphoapicose, a substance composed of apiose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-5113]
synonym: "UDP-D-apiose anabolism" EXACT []
synonym: "UDP-D-apiose biosynthesis" EXACT []
synonym: "UDP-D-apiose formation" EXACT []
synonym: "UDP-D-apiose synthesis" EXACT []
xref: MetaCyc:PWY-4821
xref: MetaCyc:PWY-5113
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033350 ! apiose biosynthetic process
is_a: GO:0033351 ! UDP-D-apiose metabolic process

[Term]
id: GO:0033353
name: S-adenosylmethionine cycle
namespace: biological_process
def: "A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl moiety and regeneration of methionine." [GOC:mah, MetaCyc:PWY-5041]
synonym: "SAM cycle" EXACT []
xref: MetaCyc:PWY-5041
is_a: GO:0046500 ! S-adenosylmethionine metabolic process

[Term]
id: GO:0033354
name: chlorophyll cycle
namespace: biological_process
def: "A cyclic series of interconversions involving chlorophyll a, chlorophyll b and several chlorophyllide intermediates." [GOC:mah, MetaCyc:PWY-5068]
xref: MetaCyc:PWY-5068
is_a: GO:0015994 ! chlorophyll metabolic process

[Term]
id: GO:0033355
name: ascorbate glutathione cycle
namespace: biological_process
def: "A cyclic series of interconversions involving L-ascorbate and glutathione that scavenges hydrogen peroxide and reduces it to water, with concomitant oxidation of NADPH." [GOC:mah, MetaCyc:PWY-2261]
synonym: "hydrogen peroxide detoxification" RELATED []
xref: MetaCyc:PWY-2261
is_a: GO:0006749 ! glutathione metabolic process
is_a: GO:0019852 ! L-ascorbic acid metabolic process
is_a: GO:0042744 ! hydrogen peroxide catabolic process

[Term]
id: GO:0033356
name: UDP-L-arabinose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate." [GOC:mah]
synonym: "UDP-L-arabinose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:0046373 ! L-arabinose metabolic process

[Term]
id: GO:0033357
name: L-arabinose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-arabinose, arabino-pentose." [ChEBI:22599, GOC:mah]
synonym: "L-arabinose anabolism" EXACT []
synonym: "L-arabinose biosynthesis" EXACT []
synonym: "L-arabinose formation" EXACT []
synonym: "L-arabinose synthesis" EXACT []
is_a: GO:0019567 ! arabinose biosynthetic process

[Term]
id: GO:0033358
name: UDP-L-arabinose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-82]
synonym: "UDP-L-arabinose anabolism" EXACT []
synonym: "UDP-L-arabinose biosynthesis" EXACT []
synonym: "UDP-L-arabinose formation" EXACT []
synonym: "UDP-L-arabinose synthesis" EXACT []
xref: MetaCyc:PWY-63
xref: MetaCyc:PWY-82
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033357 ! L-arabinose biosynthetic process

[Term]
id: GO:0033359
name: lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps." [GOC:mah, MetaCyc:DAPLYSINESYN-PWY-]
subset: gosubset_prok
synonym: "lysine anabolism via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT []
synonym: "lysine biosynthesis via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate" EXACT []
synonym: "lysine biosynthetic process via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate" EXACT []
synonym: "lysine formation via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT []
synonym: "lysine synthesis via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT []
xref: MetaCyc:DAPLYSINESYN-PWY
is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate

[Term]
id: GO:0033360
name: lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and L-2-acetamido-6-oxoheptanedioate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps." [GOC:mah, MetaCyc:PWY-2941]
subset: gosubset_prok
synonym: "lysine anabolism via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT []
synonym: "lysine biosynthesis via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate" EXACT []
synonym: "lysine biosynthetic process via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate" EXACT []
synonym: "lysine formation via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT []
synonym: "lysine synthesis via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT []
xref: MetaCyc:PWY-2941
is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate

[Term]
id: GO:0033361
name: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in a single enzymatic step." [GOC:mah, MetaCyc:PWY-2942]
subset: gosubset_prok
synonym: "lysine anabolism via diaminopimelate, dehydrogenase pathway" EXACT []
synonym: "lysine biosynthesis via diaminopimelic acid, dehydrogenase pathway" EXACT []
synonym: "lysine formation via diaminopimelate, dehydrogenase pathway" EXACT []
synonym: "lysine synthesis via diaminopimelate, dehydrogenase pathway" EXACT []
xref: MetaCyc:PWY-2942
is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate

[Term]
id: GO:0033362
name: lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in two enzymatic steps." [GOC:mah, MetaCyc:PWY-5097]
subset: gosubset_prok
synonym: "lysine anabolism via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT []
synonym: "lysine biosynthesis via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT []
synonym: "lysine formation via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT []
synonym: "lysine synthesis via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT []
xref: MetaCyc:PWY-5097
is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate

[Term]
id: GO:0033363
name: secretory granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah]
synonym: "secretory granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016050 ! vesicle organization

[Term]
id: GO:0033364
name: mast cell secretory granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a mast cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah]
synonym: "mast cell secretory granule maturation" RELATED []
synonym: "mast cell secretory granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033363 ! secretory granule organization

[Term]
id: GO:0033365
name: protein localization in organelle
namespace: biological_process
def: "A process by which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah]
synonym: "protein localization to organelle" EXACT [GOC:mah]
is_a: GO:0034613 ! cellular protein localization

[Term]
id: GO:0033366
name: protein localization in secretory granule
namespace: biological_process
def: "A process by which a protein is transported to, or maintained in, a location within a secretory granule." [GOC:mah]
synonym: "protein localization to secretory granule" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization in organelle

[Term]
id: GO:0033367
name: protein localization in mast cell secretory granule
namespace: biological_process
def: "A process by which a protein is transported to, or maintained in, a location within a secretory granule in a mast cell." [GOC:mah]
is_a: GO:0033366 ! protein localization in secretory granule
relationship: part_of GO:0033364 ! mast cell secretory granule organization

[Term]
id: GO:0033368
name: protease localization in mast cell secretory granule
namespace: biological_process
def: "Any process by which a protease is transported to, or maintained in, a location within a secretory granule in a mast cell." [GOC:mah]
is_a: GO:0033367 ! protein localization in mast cell secretory granule

[Term]
id: GO:0033369
name: establishment of protein localization in mast cell secretory granule
namespace: biological_process
def: "The directed movement of a protein to a location within a secretory granule in a mast cell." [GOC:mah]
is_a: GO:0006886 ! intracellular protein transport
relationship: part_of GO:0033367 ! protein localization in mast cell secretory granule

[Term]
id: GO:0033370
name: maintenance of protein location in mast cell secretory granule
namespace: biological_process
def: "A process by which a protein is maintained in a secretory granule in a mast cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of protein localization in mast cell secretory granule" RELATED [GOC:dph, GOC:tb]
synonym: "mast cell protein retention" EXACT []
is_a: GO:0045185 ! maintenance of protein location
relationship: part_of GO:0033367 ! protein localization in mast cell secretory granule

[Term]
id: GO:0033371
name: T cell secretory granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah]
synonym: "T cell secretory granule organization and biogenesis" RELATED [GOC:mah]
synonym: "T lymphocyte secretory granule organization" EXACT []
synonym: "T-cell secretory granule organization" EXACT []
synonym: "T-lymphocyte secretory granule maturation" RELATED []
synonym: "T-lymphocyte secretory granule organization" EXACT []
is_a: GO:0033363 ! secretory granule organization

[Term]
id: GO:0033372
name: establishment of protease localization in mast cell secretory granule
namespace: biological_process
def: "The directed movement of a protease to a location within a secretory granule in a mast cell." [GOC:mah]
is_a: GO:0033369 ! establishment of protein localization in mast cell secretory granule
relationship: part_of GO:0033368 ! protease localization in mast cell secretory granule

[Term]
id: GO:0033373
name: maintenance of protease location in mast cell secretory granule
namespace: biological_process
def: "A process by which a protease is maintained in a secretory granule in a mast cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of protease localization in mast cell secretory granule" RELATED [GOC:dph, GOC:tb]
synonym: "mast cell protease retention" EXACT []
is_a: GO:0033370 ! maintenance of protein location in mast cell secretory granule
relationship: part_of GO:0033368 ! protease localization in mast cell secretory granule

[Term]
id: GO:0033374
name: protein localization in T cell secretory granule
namespace: biological_process
def: "A process by which a protein is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah]
synonym: "protein localization in T lymphocyte secretory granule" EXACT []
synonym: "protein localization in T-cell secretory granule" EXACT []
synonym: "protein localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033366 ! protein localization in secretory granule
relationship: part_of GO:0033371 ! T cell secretory granule organization

[Term]
id: GO:0033375
name: protease localization in T cell secretory granule
namespace: biological_process
def: "Any process by which a protease is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah]
synonym: "protease localization in T lymphocyte secretory granule" EXACT []
synonym: "protease localization in T-cell secretory granule" EXACT []
synonym: "protease localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033374 ! protein localization in T cell secretory granule

[Term]
id: GO:0033376
name: establishment of protein localization in T cell secretory granule
namespace: biological_process
def: "The directed movement of a protein to a location within a secretory granule in a T cell." [GOC:mah]
synonym: "establishment of protein localization in T lymphocyte secretory granule" EXACT []
synonym: "establishment of protein localization in T-cell secretory granule" EXACT []
synonym: "establishment of protein localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0006886 ! intracellular protein transport
relationship: part_of GO:0033374 ! protein localization in T cell secretory granule

[Term]
id: GO:0033377
name: maintenance of protein location in T cell secretory granule
namespace: biological_process
def: "A process by which a protein is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of protein localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of protein localization in T lymphocyte secretory granule" EXACT []
synonym: "maintenance of protein localization in T-cell secretory granule" EXACT []
synonym: "maintenance of protein localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0045185 ! maintenance of protein location
relationship: part_of GO:0033374 ! protein localization in T cell secretory granule

[Term]
id: GO:0033378
name: establishment of protease localization in T cell secretory granule
namespace: biological_process
def: "The directed movement of a protease to a location within a secretory granule in a T cell." [GOC:mah]
synonym: "establishment of protease localization in T lymphocyte secretory granule" EXACT []
synonym: "establishment of protease localization in T-cell secretory granule" EXACT []
synonym: "establishment of protease localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033376 ! establishment of protein localization in T cell secretory granule
relationship: part_of GO:0033375 ! protease localization in T cell secretory granule

[Term]
id: GO:0033379
name: maintenance of protease location in T cell secretory granule
namespace: biological_process
def: "A process by which a protease is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb]
synonym: "maintenance of protease localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of protease localization in T lymphocyte secretory granule" EXACT []
synonym: "maintenance of protease localization in T-cell secretory granule" EXACT []
synonym: "maintenance of protease localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033377 ! maintenance of protein location in T cell secretory granule
relationship: part_of GO:0033375 ! protease localization in T cell secretory granule

[Term]
id: GO:0033380
name: granzyme B localization in T cell secretory granule
namespace: biological_process
def: "Any process by which the protease granzyme B is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah]
synonym: "granzyme B localization in T lymphocyte secretory granule" EXACT []
synonym: "granzyme B localization in T-cell secretory granule" EXACT []
synonym: "granzyme B localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033375 ! protease localization in T cell secretory granule

[Term]
id: GO:0033381
name: establishment of granzyme B localization in T cell secretory granule
namespace: biological_process
def: "The directed movement of the protease granzyme B to a location within a secretory granule in a T cell." [GOC:mah]
synonym: "establishment of granzyme B localization in T lymphocyte secretory granule" EXACT []
synonym: "establishment of granzyme B localization in T-cell secretory granule" EXACT []
synonym: "establishment of granzyme B localization in T-lymphocyte secretory granule" EXACT []
synonym: "T-lymphocyte secretory granule storage of granzyme B" RELATED []
is_a: GO:0033378 ! establishment of protease localization in T cell secretory granule
relationship: part_of GO:0033380 ! granzyme B localization in T cell secretory granule

[Term]
id: GO:0033382
name: maintenance of granzyme B location in T cell secretory granule
namespace: biological_process
def: "A process by which the protease granyme B is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:mah]
synonym: "maintenance of granzyme B localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of granzyme B localization in T lymphocyte secretory granule" EXACT []
synonym: "maintenance of granzyme B localization in T-cell secretory granule" EXACT []
synonym: "maintenance of granzyme B localization in T-lymphocyte secretory granule" EXACT []
is_a: GO:0033379 ! maintenance of protease location in T cell secretory granule
relationship: part_of GO:0033380 ! granzyme B localization in T cell secretory granule

[Term]
id: GO:0033383
name: geranyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes." [GOC:mah, MetaCyc:PWY-5122]
synonym: "geranyl diphosphate metabolism" EXACT []
synonym: "geranyldiphosphate metabolic process" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006721 ! terpenoid metabolic process
is_a: GO:0016093 ! polyprenol metabolic process

[Term]
id: GO:0033384
name: geranyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of geranyl diphosphate." [GOC:mah, MetaCyc:PWY-5122]
synonym: "geranyl diphosphate anabolism" EXACT []
synonym: "geranyl diphosphate biosynthesis" EXACT []
synonym: "geranyl diphosphate formation" EXACT []
synonym: "geranyl diphosphate synthesis" EXACT []
synonym: "geranyldiphosphate biosynthetic process" EXACT []
xref: MetaCyc:PWY-5122
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016094 ! polyprenol biosynthetic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0033383 ! geranyl diphosphate metabolic process

[Term]
id: GO:0033385
name: geranylgeranyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins." [GOC:mah, MetaCyc:PWY-5120]
synonym: "geranylgeranyl diphosphate metabolism" EXACT []
synonym: "geranylgeranyldiphosphate metabolic process" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006721 ! terpenoid metabolic process
is_a: GO:0016093 ! polyprenol metabolic process

[Term]
id: GO:0033386
name: geranylgeranyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate." [GOC:mah, MetaCyc:PWY-5120]
synonym: "geranylgeranyl diphosphate anabolism" EXACT []
synonym: "geranylgeranyl diphosphate biosynthesis" EXACT []
synonym: "geranylgeranyl diphosphate formation" EXACT []
synonym: "geranylgeranyl diphosphate synthesis" EXACT []
synonym: "geranylvdiphosphate biosynthetic process" EXACT []
xref: MetaCyc:PWY-5120
xref: MetaCyc:PWY-5121
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016094 ! polyprenol biosynthetic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0033385 ! geranylgeranyl diphosphate metabolic process

[Term]
id: GO:0033387
name: putrescine biosynthetic process from ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine." [GOC:mah, MetaCyc:PWY-46]
synonym: "putrescine anabolism from ornithine" EXACT []
synonym: "putrescine biosynthesis from ornithine" EXACT []
synonym: "putrescine formation from ornithine" EXACT []
synonym: "putrescine synthesis from ornithine" EXACT []
is_a: GO:0009446 ! putrescine biosynthetic process

[Term]
id: GO:0033388
name: putrescine biosynthetic process from arginine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine." [GOC:mah, MetaCyc:PWY-46]
subset: gosubset_prok
synonym: "putrescine anabolism from arginine" EXACT []
synonym: "putrescine biosynthesis from arginine" EXACT []
synonym: "putrescine formation from arginine" EXACT []
synonym: "putrescine synthesis from arginine" EXACT []
is_a: GO:0009446 ! putrescine biosynthetic process

[Term]
id: GO:0033389
name: putrescine biosynthetic process from arginine, using agmatinase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in a single enzymatic step." [GOC:mah, MetaCyc:PWY-40]
subset: gosubset_prok
synonym: "putrescine anabolism from arginine, using agmatinase" EXACT []
synonym: "putrescine biosynthesis from arginine, using agmatinase" EXACT []
synonym: "putrescine formation from arginine, using agmatinase" EXACT []
synonym: "putrescine synthesis from arginine, using agmatinase" EXACT []
is_a: GO:0033388 ! putrescine biosynthetic process from arginine

[Term]
id: GO:0033390
name: putrescine biosynthetic process from arginine via N-carbamoylputrescine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine, via the intermediate N-carbamoylputrescine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in two single enzymatic steps." [GOC:mah, MetaCyc:PWY-43]
subset: gosubset_prok
synonym: "putrescine anabolism from arginine via N-carbamoylputrescine" EXACT []
synonym: "putrescine biosynthesis from arginine via N-carbamoylputrescine" EXACT []
synonym: "putrescine formation from arginine via N-carbamoylputrescine" EXACT []
synonym: "putrescine synthesis from arginine via N-carbamoylputrescine" EXACT []
is_a: GO:0033388 ! putrescine biosynthetic process from arginine

[Term]
id: GO:0033391
name: chromatoid body
namespace: cellular_component
def: "A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182)." [PMID:17183363]
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0033392
name: actin homodimerization activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an identical actin monomer to form a homodimer." [GOC:mah]
subset: gosubset_prok
synonym: "actin dimerization activity" BROAD []
synonym: "actin polymerizing activity" RELATED []
is_a: GO:0042803 ! protein homodimerization activity

[Term]
id: GO:0033393
name: homogalacturonan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of homogalacturonan, a pectidic polymer, characterized by a backbone of 1,4-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [GOC:mah]
subset: gosubset_prok
synonym: "homogalacturonan breakdown" EXACT []
synonym: "homogalacturonan catabolism" EXACT []
synonym: "homogalacturonan degradation" EXACT []
xref: MetaCyc:PWY-1081
is_a: GO:0045490 ! pectin catabolic process

[Term]
id: GO:0033394
name: beta-alanine biosynthetic process via 1,3 diaminopropane
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 1,3 diaminopropane." [GOC:mah, MetaCyc:PWY-3981]
synonym: "beta-alanine anabolism via 1,3 diaminopropane" EXACT []
synonym: "beta-alanine biosynthesis via 1,3 diaminopropane" EXACT []
synonym: "beta-alanine formation via 1,3 diaminopropane" EXACT []
synonym: "beta-alanine synthesis via 1,3 diaminopropane" EXACT []
xref: MetaCyc:PWY-3981
is_a: GO:0019483 ! beta-alanine biosynthetic process

[Term]
id: GO:0033395
name: beta-alanine biosynthetic process via 3-hydroxypropionate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-hydroxypropionate." [GOC:mah, MetaCyc:PWY-3941]
synonym: "beta-alanine anabolism via 3-hydroxypropionate" EXACT []
synonym: "beta-alanine biosynthesis via 3-hydroxypropionate" EXACT []
synonym: "beta-alanine formation via 3-hydroxypropionate" EXACT []
synonym: "beta-alanine synthesis via 3-hydroxypropionate" EXACT []
xref: MetaCyc:PWY-3941
is_a: GO:0019483 ! beta-alanine biosynthetic process

[Term]
id: GO:0033396
name: beta-alanine biosynthetic process via 3-ureidopropionate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-ureidopropionate." [GOC:mah, MetaCyc:PWY-3982]
synonym: "beta-alanine anabolism via 3-ureidopropionate" EXACT []
synonym: "beta-alanine formation via 3-ureidopropionate" EXACT []
synonym: "beta-alanine synthesis via 3-ureidopropionate" EXACT []
xref: MetaCyc:PWY-3982
is_a: GO:0019483 ! beta-alanine biosynthetic process

[Term]
id: GO:0033397
name: zeatin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [ChEBI:15333, GOC:mah]
synonym: "zeatin metabolism" EXACT []
is_a: GO:0009690 ! cytokinin metabolic process

[Term]
id: GO:0033398
name: zeatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [ChEBI:15333, GOC:mah]
subset: gosubset_prok
synonym: "zeatin anabolism" EXACT []
synonym: "zeatin biosynthesis" EXACT []
synonym: "zeatin formation" EXACT []
synonym: "zeatin synthesis" EXACT []
is_a: GO:0009691 ! cytokinin biosynthetic process
is_a: GO:0033397 ! zeatin metabolic process

[Term]
id: GO:0033399
name: cis-zeatin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [ChEBI:12800, GOC:mah]
synonym: "cis-zeatin metabolism" EXACT []
is_a: GO:0033397 ! zeatin metabolic process

[Term]
id: GO:0033400
name: trans-zeatin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [ChEBI:16522, GOC:mah]
synonym: "trans-zeatin metabolism" EXACT []
is_a: GO:0033397 ! zeatin metabolic process

[Term]
id: GO:0033401
name: UUU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UUU codon." [GOC:mah]
comment: Note that in the standard genetic code, TTT codes for phenylalanine.
synonym: "phenylalanine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TTT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033402
name: UUC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UUC codon." [GOC:mah]
comment: Note that in the standard genetic code, TTC codes for phenylalanine.
synonym: "phenylalanine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TTC codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033403
name: UUA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UUA codon." [GOC:mah]
comment: Note that in the standard genetic code, TTA codes for leucine.
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TTA codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033404
name: UUG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UUG codon." [GOC:mah]
comment: Note that in the standard genetic code, TTG codes for leucine.
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TTG codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033405
name: UCU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UCU codon." [GOC:mah]
comment: Note that in the standard genetic code, TCT codes for serine.
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TCT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033406
name: UCC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UCC codon." [GOC:mah]
comment: Note that in the standard genetic code, TCC codes for serine.
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TCC codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033407
name: UCA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UCA codon." [GOC:mah]
comment: Note that in the standard genetic code, TCA codes for serine.
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TCA codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033408
name: UCG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UCG codon." [GOC:mah]
comment: Note that in the standard genetic code, TCG codes for serine.
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TCG codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033409
name: UAU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UAU codon." [GOC:mah]
comment: Note that in the standard genetic code, TAT codes for tyrosine.
synonym: "TAT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "tyrosine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033410
name: UAC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UAC codon." [GOC:mah]
comment: Note that in the standard genetic code, TAC codes for tyrosine.
synonym: "TAC codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "tyrosine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033411
name: UAA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UAA codon." [GOC:mah]
comment: Note that in the standard genetic code, TAA is a stop codon (ochre) and is not normally read by a tRNA.
synonym: "TAA codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033412
name: UAG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UAG codon." [GOC:mah]
comment: Note that in the standard genetic code, TAG is a stop codon (amber) and is not normally read by a tRNA.
synonym: "TAG codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033413
name: UGU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UGU codon." [GOC:mah]
comment: Note that in the standard genetic code, TGT codes for cysteine.
synonym: "cysteine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TGT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033414
name: UGC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UGC codon." [GOC:mah]
comment: Note that in the standard genetic code, TGC codes for cysteine.
synonym: "cysteine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "TGC codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033415
name: UGA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UGA codon." [GOC:mah]
comment: Note that in the standard genetic code, TGA is a stop codon (opal) and is not normally read by a tRNA.
synonym: "TGA codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033416
name: UGG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a UGG codon." [GOC:mah]
comment: Note that in the standard genetic code, TGG codes for tryptophan.
synonym: "TGG codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "tryptophan tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033417
name: CUU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CUU codon." [GOC:mah]
comment: Note that in the standard genetic code, CTT codes for leucine.
synonym: "CTT codon-amino acid adaptor activity" EXACT [GOC:mah]
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033418
name: CUC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CUC codon." [GOC:mah]
comment: Note that in the standard genetic code, CTC codes for leucine.
synonym: "CTC codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033419
name: CUA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CUA codon." [GOC:mah]
comment: Note that in the standard genetic code, CTA codes for leucine.
synonym: "CTA codon-amino acid adaptor activity" EXACT [GOC:mah]
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033420
name: CUG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CUG codon." [GOC:mah]
comment: Note that in the standard genetic code, CTG codes for leucine.
synonym: "CTG codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033421
name: CCU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CCU codon." [GOC:mah]
comment: Note that in the standard genetic code, CCT codes for proline.
synonym: "CCT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033422
name: CCC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CCC codon." [GOC:mah]
comment: Note that in the standard genetic code, CCC codes for proline.
synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033423
name: CCA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CCA codon." [GOC:mah]
comment: Note that in the standard genetic code, CCA codes for proline.
synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033424
name: CCG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CCG codon." [GOC:mah]
comment: Note that in the standard genetic code, CCG codes for proline.
synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033425
name: CAU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CAU codon." [GOC:mah]
comment: Note that in the standard genetic code, CAT codes for histidine.
synonym: "CAT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "histidine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033426
name: CAC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CAC codon." [GOC:mah]
comment: Note that in the standard genetic code, CAC codes for histidine.
synonym: "histidine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033427
name: CAA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CAA codon." [GOC:mah]
comment: Note that in the standard genetic code, CAA codes for glutamine.
synonym: "glutamine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033428
name: CAG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CAG codon." [GOC:mah]
comment: Note that in the standard genetic code, CAG codes for glutamine.
synonym: "glutamine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033429
name: CGU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CGU codon." [GOC:mah]
comment: Note that in the standard genetic code, CGT codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "CGT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033430
name: CGC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CGC codon." [GOC:mah]
comment: Note that in the standard genetic code, CGC codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033431
name: CGA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CGA codon." [GOC:mah]
comment: Note that in the standard genetic code, CGA codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033432
name: CGG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a CGG codon." [GOC:mah]
comment: Note that in the standard genetic code, CGG codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033433
name: AUU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AUU codon." [GOC:mah]
comment: Note that in the standard genetic code, ATT codes for isoleucine.
synonym: "ATT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033434
name: AUC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AUC codon." [GOC:mah]
comment: Note that in the standard genetic code, ATC codes for isoleucine.
synonym: "ATC codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033435
name: AUA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AUA codon." [GOC:mah]
comment: Note that in the standard genetic code, ATA codes for isoleucine.
synonym: "ATA codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033436
name: AUG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AUG codon." [GOC:mah]
comment: Note that in the standard genetic code, ATG codes for methionine, and is the initiator codon.
synonym: "ATG codon-amino acid adaptor activity" EXACT [GOC:mah]
synonym: "initiator methionine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "methionine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033437
name: ACU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an ACU codon." [GOC:mah]
comment: Note that in the standard genetic code, ACT codes for threonine.
synonym: "ACT codon-amino acid adaptor activity" EXACT [GOC:mah]
synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033438
name: ACC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an ACC codon." [GOC:mah]
comment: Note that in the standard genetic code, ACC codes for threonine.
synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033439
name: ACA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an ACA codon." [GOC:mah]
comment: Note that in the standard genetic code, ACA codes for threonine.
synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033440
name: ACG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an ACG codon." [GOC:mah]
comment: Note that in the standard genetic code, ACG codes for threonine.
synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033441
name: AAU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AAU codon." [GOC:mah]
comment: Note that in the standard genetic code, AAT codes for asparagine.
synonym: "AAT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "asparagine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033442
name: AAC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AAC codon." [GOC:mah]
comment: Note that in the standard genetic code, AAC codes for asparagine.
synonym: "asparagine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033443
name: AAA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AAA codon." [GOC:mah]
comment: Note that in the standard genetic code, AAA codes for lysine.
synonym: "lysine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033444
name: AAG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AAG codon." [GOC:mah]
comment: Note that in the standard genetic code, AAG codes for lysine.
synonym: "lysine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033445
name: AGU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AGU codon." [GOC:mah]
comment: Note that in the standard genetic code, AGT codes for serine.
synonym: "AGT codon-amino acid adaptor activity" EXACT [GOC:mah]
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033446
name: AGC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AGC codon." [GOC:mah]
comment: Note that in the standard genetic code, AGC codes for serine.
synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033447
name: AGA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AGA codon." [GOC:mah]
comment: Note that in the standard genetic code, AGA codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033448
name: AGG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes an AGG codon." [GOC:mah]
comment: Note that in the standard genetic code, AGG codes for arginine.
synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033449
name: GUU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GUU codon." [GOC:mah]
comment: Note that in the standard genetic code, GTT codes for valine.
synonym: "GTT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033450
name: GUC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GUC codon." [GOC:mah]
comment: Note that in the standard genetic code, GTC codes for valine.
synonym: "GTC codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033451
name: GUA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GUA codon." [GOC:mah]
comment: Note that in the standard genetic code, GTA codes for valine.
synonym: "GTA codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033452
name: GUG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GUG codon." [GOC:mah]
comment: Note that in the standard genetic code, GTG codes for valine.
synonym: "GTG codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033453
name: GCU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GCU codon." [GOC:mah]
comment: Note that in the standard genetic code, GCT codes for alanine.
synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "GCT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033454
name: GCC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GCC codon." [GOC:mah]
comment: Note that in the standard genetic code, GCC codes for alanine.
synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033455
name: GCA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GCA codon." [GOC:mah]
comment: Note that in the standard genetic code, GCA codes for alanine.
synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033456
name: GCG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GCG codon." [GOC:mah]
comment: Note that in the standard genetic code, GCG codes for alanine.
synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033457
name: GAU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GAU codon." [GOC:mah]
comment: Note that in the standard genetic code, GAT codes for aspartic acid.
synonym: "aspartic acid tRNA" RELATED [GOC:hjd, GOC:mah]
synonym: "GAT codon-amino acid adaptor activity" EXACT [GOC:hjd]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033458
name: GAC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GAC codon." [GOC:mah]
comment: Note that in the standard genetic code, GAC codes for aspartic acid.
synonym: "aspartic acid tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033459
name: GAA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GAA codon." [GOC:mah]
comment: Note that in the standard genetic code, GAA codes for glutamic acid.
synonym: "glutamic acid tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033460
name: GAG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GAG codon." [GOC:mah]
comment: Note that in the standard genetic code, GAG codes for glutamic acid.
synonym: "glutamic acid tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033461
name: GGU codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GGU codon." [GOC:mah]
comment: Note that in the standard genetic code, GGT codes for glycine.
synonym: "GGT codon-amino acid adaptor activity" EXACT [GOC:hjd]
synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033462
name: GGC codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GGC codon." [GOC:mah]
comment: Note that in the standard genetic code, GGC codes for glycine.
synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033463
name: GGA codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GGA codon." [GOC:mah]
comment: Note that in the standard genetic code, GGA codes for glycine.
synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033464
name: GGG codon-amino acid adaptor activity
namespace: molecular_function
def: "A triplet codon-amino acid adaptor activity that recognizes a GGG codon." [GOC:mah]
comment: Note that in the standard genetic code, GGG codes for glycine.
synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah]
is_a: GO:0030533 ! triplet codon-amino acid adaptor activity

[Term]
id: GO:0033465
name: cis-zeatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [ChEBI:12800, GOC:mah]
subset: gosubset_prok
synonym: "cis-zeatin anabolism" EXACT []
synonym: "cis-zeatin biosynthesis" EXACT []
synonym: "cis-zeatin formation" EXACT []
synonym: "cis-zeatin synthesis" EXACT []
xref: MetaCyc:PWY-2781
is_a: GO:0033398 ! zeatin biosynthetic process
is_a: GO:0033399 ! cis-zeatin metabolic process

[Term]
id: GO:0033466
name: trans-zeatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [ChEBI:16522, GOC:mah]
subset: gosubset_prok
synonym: "trans-zeatin anabolism" EXACT []
synonym: "trans-zeatin biosynthesis" EXACT []
synonym: "trans-zeatin formation" EXACT []
synonym: "trans-zeatin synthesis" EXACT []
xref: MetaCyc:PWY-2681
is_a: GO:0033398 ! zeatin biosynthetic process
is_a: GO:0033400 ! trans-zeatin metabolic process

[Term]
id: GO:0033467
name: CMP-keto-3-deoxy-D-manno-octulosonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:mah, MetaCyc:PWY-5111]
synonym: "CMP-KDO metabolic process" EXACT []
synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid metabolism" EXACT []
synonym: "CMP-ketodeoxyoctanoate metabolic process" RELATED [ISBN:0198506732]
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:0046400 ! keto-3-deoxy-D-manno-octulosonic acid metabolic process

[Term]
id: GO:0033468
name: CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:mah, MetaCyc:PWY-5111]
subset: gosubset_prok
synonym: "CMP-KDO biosynthesis" EXACT []
synonym: "CMP-KDO biosynthetic process" EXACT []
synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid anabolism" EXACT []
synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthesis" EXACT []
synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid formation" EXACT []
synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid synthesis" EXACT []
synonym: "CMP-ketodeoxyoctanoate biosynthetic process" RELATED [ISBN:0198506732]
xref: MetaCyc:KDOSYN-PWY
xref: MetaCyc:PWY-1269
xref: MetaCyc:PWY-5111
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0019294 ! keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
is_a: GO:0033467 ! CMP-keto-3-deoxy-D-manno-octulosonic acid metabolic process

[Term]
id: GO:0033469
name: gibberellin 12 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid." [ChEBI:30088, GOC:mah]
synonym: "GA12 metabolic process" EXACT []
synonym: "gibberellin 12 metabolism" EXACT []
synonym: "gibberellin A12 metabolic process" EXACT []
is_a: GO:0009685 ! gibberellin metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0033470
name: gibberellin 12 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid." [ChEBI:30088, GOC:mah]
synonym: "GA12 biosynthetic process" EXACT []
synonym: "gibberellin 12 anabolism" EXACT []
synonym: "gibberellin 12 biosynthesis" EXACT []
synonym: "gibberellin 12 formation" EXACT []
synonym: "gibberellin 12 synthesis" EXACT []
synonym: "gibberellin A12 biosynthetic process" EXACT []
xref: MetaCyc:PWY-5034
is_a: GO:0009686 ! gibberellin biosynthetic process
is_a: GO:0033469 ! gibberellin 12 metabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0033471
name: GDP-L-galactose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate." [GOC:mah]
synonym: "GDP-L-galactose metabolism" EXACT []
is_a: GO:0006012 ! galactose metabolic process
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0033472
name: GDP-L-galactose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate." [GOC:mah]
synonym: "GDP-L-galactose anabolism" EXACT []
synonym: "GDP-L-galactose biosynthesis" EXACT []
synonym: "GDP-L-galactose formation" EXACT []
synonym: "GDP-L-galactose synthesis" EXACT []
xref: MetaCyc:PWY-5115
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033471 ! GDP-L-galactose metabolic process

[Term]
id: GO:0033473
name: indoleacetic acid conjugate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule." [GOC:mah]
synonym: "IAA conjugate metabolic process" EXACT []
synonym: "indole acetic acid conjugate metabolic process" EXACT []
synonym: "indole acetic acid conjugate metabolism" EXACT []
synonym: "indoleacetic acid conjugate metabolism" EXACT []
is_a: GO:0009683 ! indoleacetic acid metabolic process

[Term]
id: GO:0033474
name: indoleacetic acid conjugate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule." [GOC:mah]
synonym: "IAA conjugate biosynthetic process" EXACT []
synonym: "indole acetic acid conjugate biosynthesis" EXACT []
synonym: "indole acetic acid conjugate biosynthetic process" EXACT []
synonym: "indoleacetic acid conjugate anabolism" EXACT []
synonym: "indoleacetic acid conjugate biosynthesis" EXACT []
synonym: "indoleacetic acid conjugate formation" EXACT []
synonym: "indoleacetic acid conjugate synthesis" EXACT []
is_a: GO:0009851 ! auxin biosynthetic process
is_a: GO:0033473 ! indoleacetic acid conjugate metabolic process
is_a: GO:0042435 ! indole derivative biosynthetic process

[Term]
id: GO:0033475
name: indoleacetic acid amide conjugate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an amino acid or polypeptide through an amide bond." [GOC:mah, MetaCyc:PWY-1782]
synonym: "IAA amide conjugate biosynthetic process" EXACT []
synonym: "indole acetic acid amide conjugate biosynthesis" EXACT []
synonym: "indole acetic acid amide conjugate biosynthetic process" EXACT []
synonym: "indoleacetic acid amide conjugate anabolism" EXACT []
synonym: "indoleacetic acid amide conjugate biosynthesis" EXACT []
synonym: "indoleacetic acid amide conjugate formation" EXACT []
synonym: "indoleacetic acid amide conjugate synthesis" EXACT []
xref: MetaCyc:PWY-1782
is_a: GO:0033474 ! indoleacetic acid conjugate biosynthetic process

[Term]
id: GO:0033476
name: indoleacetic acid ester conjugate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an a sugar or polyol through an ester bond." [GOC:mah, MetaCyc:PWY-1741]
synonym: "IAA ester conjugate biosynthetic process" EXACT []
synonym: "indole acetic acid ester conjugate biosynthesis" EXACT []
synonym: "indole acetic acid ester conjugate biosynthetic process" EXACT []
synonym: "indoleacetic acid ester conjugate anabolism" EXACT []
synonym: "indoleacetic acid ester conjugate biosynthesis" EXACT []
synonym: "indoleacetic acid ester conjugate formation" EXACT []
synonym: "indoleacetic acid ester conjugate synthesis" EXACT []
xref: MetaCyc:PWY-1741
is_a: GO:0033474 ! indoleacetic acid conjugate biosynthetic process

[Term]
id: GO:0033477
name: S-methylmethionine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving S-methyl-methionine (SMM). SMM can be converted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle." [GOC:mah, PMID:12692340]
synonym: "S-methylmethionine metabolism" EXACT []
is_a: GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0033478
name: UDP-rhamnose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate." [GOC:mah, PMID:15134748]
synonym: "UDP-rhamnose metabolism" EXACT []
xref: MetaCyc:PWY-3261
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:0019299 ! rhamnose metabolic process

[Term]
id: GO:0033479
name: UDP-D-galacturonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate." [GOC:mah]
synonym: "UDP-D-galacturonate metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:0046396 ! D-galacturonate metabolic process

[Term]
id: GO:0033480
name: UDP-D-galacturonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate." [GOC:mah]
synonym: "UDP-D-galacturonate anabolism" EXACT []
synonym: "UDP-D-galacturonate biosynthesis" EXACT []
synonym: "UDP-D-galacturonate formation" EXACT []
synonym: "UDP-D-galacturonate synthesis" EXACT []
xref: MetaCyc:PWY-4
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0033479 ! UDP-D-galacturonate metabolic process
is_a: GO:0033482 ! D-galacturonate biosynthetic process

[Term]
id: GO:0033481
name: galacturonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galacturonate, the anion of galacturonic acid." [GOC:mah]
synonym: "galacturonate anabolism" EXACT []
synonym: "galacturonate biosynthesis" EXACT []
synonym: "galacturonate formation" EXACT []
synonym: "galacturonate synthesis" EXACT []
is_a: GO:0019586 ! galacturonate metabolic process
is_a: GO:0046364 ! monosaccharide biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0033482
name: D-galacturonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid." [GOC:jsg, GOC:mah]
synonym: "D-galacturonate anabolism" EXACT []
synonym: "D-galacturonate biosynthesis" EXACT []
synonym: "D-galacturonate formation" EXACT []
synonym: "D-galacturonate synthesis" EXACT []
is_a: GO:0033481 ! galacturonate biosynthetic process
is_a: GO:0046396 ! D-galacturonate metabolic process

[Term]
id: GO:0033483
name: gas homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal equilibrium of a gas within an organism or cell." [GOC:mah]
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0033484
name: nitric oxide homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal equilibrium of nitric oxide within an organism or cell." [GOC:mah]
synonym: "NO homeostasis" EXACT []
is_a: GO:0033483 ! gas homeostasis

[Term]
id: GO:0033485
name: cyanidin 3-O-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyanidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5125]
synonym: "cyanidin 3-O-glucoside anabolism" EXACT []
synonym: "cyanidin 3-O-glucoside biosynthesis" EXACT []
synonym: "cyanidin 3-O-glucoside formation" EXACT []
synonym: "cyanidin 3-O-glucoside synthesis" EXACT []
xref: MetaCyc:PWY-5125
is_a: GO:0009718 ! anthocyanin biosynthetic process
is_a: GO:0016140 ! O-glycoside metabolic process

[Term]
id: GO:0033486
name: delphinidin 3-O-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of delphinidin 3-O-glucoside, a basic, water-soluble anthocyanin responsible for blue coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5153]
synonym: "delphinidin 3-O-glucoside anabolism" EXACT []
synonym: "delphinidin 3-O-glucoside biosynthesis" EXACT []
synonym: "delphinidin 3-O-glucoside formation" EXACT []
synonym: "delphinidin 3-O-glucoside synthesis" EXACT []
xref: MetaCyc:PWY-5153
is_a: GO:0009718 ! anthocyanin biosynthetic process
is_a: GO:0016140 ! O-glycoside metabolic process

[Term]
id: GO:0033487
name: pelargonidin 3-O-glucoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pelargonidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5125]
synonym: "pelargonidin 3-O-glucoside anabolism" EXACT []
synonym: "pelargonidin 3-O-glucoside biosynthesis" EXACT []
synonym: "pelargonidin 3-O-glucoside formation" EXACT []
synonym: "pelargonidin 3-O-glucoside synthesis" EXACT []
xref: MetaCyc:PWY-5125
is_a: GO:0009718 ! anthocyanin biosynthetic process
is_a: GO:0016140 ! O-glycoside metabolic process

[Term]
id: GO:0033488
name: cholesterol biosynthetic process via 24,25-dihydrolanosterol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate 24,25-dihydrolanosterol." [GOC:mah, MetaCyc:PWY66-3]
synonym: "cholesterol anabolism via 24,25-dihydrolanosterol" EXACT []
synonym: "cholesterol biosynthesis via 24,25-dihydrolanosterol" EXACT []
synonym: "cholesterol formation via 24,25-dihydrolanosterol" EXACT []
synonym: "cholesterol synthesis via 24,25-dihydrolanosterol" EXACT []
xref: MetaCyc:PWY66-3
is_a: GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0033489
name: cholesterol biosynthetic process via desmosterol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate desmosterol." [GOC:mah, MetaCyc:PWY66-4]
synonym: "cholesterol anabolism via desmosterol" EXACT []
synonym: "cholesterol biosynthesis via desmosterol" EXACT []
synonym: "cholesterol formation via desmosterol" EXACT []
synonym: "cholesterol synthesis via desmosterol" EXACT []
xref: MetaCyc:PWY66-4
is_a: GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0033490
name: cholesterol biosynthetic process via lathosterol
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol." [GOC:mah, MetaCyc:PWY66-341]
synonym: "cholesterol anabolism via lathosterol" EXACT []
synonym: "cholesterol biosynthesis via lathosterol" EXACT []
synonym: "cholesterol formation via lathosterol" EXACT []
synonym: "cholesterol synthesis via lathosterol" EXACT []
xref: MetaCyc:PWY66-341
is_a: GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0033491
name: coniferin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving coniferin, 4-(3-hydroxyprop-1-en-1-yl)-2-methoxyphenyl beta-D-glucopyranoside." [ChEBI:16220, GOC:mah, MetaCyc:PWY-116]
synonym: "coniferin metabolism" EXACT []
xref: MetaCyc:PWY-116
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0016137 ! glycoside metabolic process

[Term]
id: GO:0033492
name: esculetin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving esculetin, 6,7-dihydroxycoumarin." [GOC:mah]
synonym: "esculetin metabolism" EXACT []
is_a: GO:0009804 ! coumarin metabolic process

[Term]
id: GO:0033493
name: esculetin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of esculetin, 6,7-dihydroxycoumarin." [GOC:mah]
synonym: "esculetin anabolism" EXACT []
synonym: "esculetin biosynthesis" EXACT []
synonym: "esculetin formation" EXACT []
synonym: "esculetin synthesis" EXACT []
xref: MetaCyc:PWY-5349
is_a: GO:0009805 ! coumarin biosynthetic process
is_a: GO:0033492 ! esculetin metabolic process

[Term]
id: GO:0033494
name: ferulate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate." [ChEBI:29749, GOC:mah]
synonym: "ferulate metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0033495
name: ferulate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate." [ChEBI:29749, GOC:mah]
synonym: "ferulate anabolism" EXACT []
synonym: "ferulate biosynthesis" EXACT []
synonym: "ferulate formation" EXACT []
synonym: "ferulate synthesis" EXACT []
xref: MetaCyc:PWY-5168
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0033494 ! ferulate metabolic process

[Term]
id: GO:0033496
name: sinapate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [ChEBI:30023, GOC:mah]
synonym: "sinapate metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process

[Term]
id: GO:0033497
name: sinapate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [ChEBI:30023, GOC:mah]
synonym: "sinapate anabolism" EXACT []
synonym: "sinapate biosynthesis" EXACT []
synonym: "sinapate formation" EXACT []
synonym: "sinapate synthesis" EXACT []
xref: MetaCyc:PWY-5168
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0033496 ! sinapate metabolic process

[Term]
id: GO:0033498
name: galactose catabolic process via D-galactonate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate D-galactonate." [GOC:mah, MetaCyc:GALDEG-PWY]
subset: gosubset_prok
synonym: "galactose breakdown via D-galactonate" EXACT []
synonym: "galactose catabolism via D-galactonate" EXACT []
synonym: "galactose degradation via D-galactonate" EXACT []
xref: MetaCyc:GALDEG-PWY
is_a: GO:0019388 ! galactose catabolic process

[Term]
id: GO:0033499
name: galactose catabolic process via UDP-galactose
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose." [GOC:mah, MetaCyc:PWY-3821]
synonym: "galactose breakdown via UDP-galactose" EXACT []
synonym: "galactose catabolism via UDP-galactose" EXACT []
synonym: "galactose degradation via UDP-galactose" EXACT []
xref: MetaCyc:PWY-3821
is_a: GO:0019388 ! galactose catabolic process

[Term]
id: GO:0033500
name: carbohydrate homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal equilibrium of a carbohydrate within an organism or cell." [GOC:mah]
subset: gosubset_prok
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0033501
name: galactose homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal equilibrium of galactose within an organism or cell." [GOC:mah]
is_a: GO:0033500 ! carbohydrate homeostasis

[Term]
id: GO:0033502
name: cellular galactose homeostasis
namespace: biological_process
def: "A cellular homeostatic process involved in the maintenance of an internal equilibrium of galactose within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb]
subset: gosubset_prok
synonym: "cell galactose homeostasis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0033501 ! galactose homeostasis
is_a: GO:0055082 ! cellular chemical homeostasis

[Term]
id: GO:0033503
name: HULC complex
namespace: cellular_component
def: "A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp1, Brl2/Rfp1 and Brl1/Rfp2." [GOC:mah, PMID:17363370, PMID:17374714]
is_a: GO:0000151 ! ubiquitin ligase complex
is_a: GO:0031371 ! ubiquitin conjugating enzyme complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000792 ! heterochromatin

[Term]
id: GO:0033504
name: floor plate development
namespace: biological_process
def: "The progression of the floor plate over time from its initial formation until its mature state." [GOC:dh]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021915 ! neural tube development

[Term]
id: GO:0033505
name: floor plate morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the floor plate is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dh]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0033504 ! floor plate development

[Term]
id: GO:0033506
name: glucosinolate biosynthetic process from homomethionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including homomethionine." [GOC:mah, MetaCyc:PWY-1187]
subset: gosubset_prok
synonym: "glucosinolate anabolism from homomethionine" EXACT []
synonym: "glucosinolate biosynthesis from homomethionine" EXACT []
synonym: "glucosinolate formation from homomethionine" EXACT []
synonym: "glucosinolate synthesis from homomethionine" EXACT []
xref: MetaCyc:PWY-1187
is_a: GO:0019761 ! glucosinolate biosynthetic process

[Term]
id: GO:0033507
name: glucosinolate biosynthetic process from phenylalanine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including phenylalanine." [GOC:mah, MetaCyc:PWY-2821]
subset: gosubset_prok
synonym: "glucosinolate anabolism from phenylalanine" EXACT []
synonym: "glucosinolate biosynthesis from phenylalanine" EXACT []
synonym: "glucosinolate formation from phenylalanine" EXACT []
synonym: "glucosinolate synthesis from phenylalanine" EXACT []
xref: MetaCyc:PWY-2821
is_a: GO:0019761 ! glucosinolate biosynthetic process

[Term]
id: GO:0033508
name: glutamate catabolic process to butyrate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including butyrate." [GOC:mah, MetaCyc:PWY-5087]
subset: gosubset_prok
synonym: "glutamate breakdown to butyrate" EXACT []
synonym: "glutamate degradation to butyrate" EXACT []
xref: MetaCyc:PWY-5087
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0019605 ! butyrate metabolic process

[Term]
id: GO:0033509
name: glutamate catabolic process to propionate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including propionate." [GOC:mah, MetaCyc:PWY-5088]
subset: gosubset_prok
synonym: "glutamate breakdown to propionate" EXACT []
synonym: "glutamate degradation to propionate" EXACT []
xref: MetaCyc:PWY-5088
is_a: GO:0006538 ! glutamate catabolic process
is_a: GO:0019541 ! propionate metabolic process

[Term]
id: GO:0033510
name: luteolin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." [ChEBI:15864, GOC:mah]
synonym: "luteolin metabolism" EXACT []
is_a: GO:0051552 ! flavone metabolic process

[Term]
id: GO:0033511
name: luteolin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." [ChEBI:15864, GOC:mah]
synonym: "luteolin anabolism" EXACT []
synonym: "luteolin biosynthesis" EXACT []
synonym: "luteolin formation" EXACT []
synonym: "luteolin synthesis" EXACT []
xref: MetaCyc:PWY-5060
is_a: GO:0033510 ! luteolin metabolic process
is_a: GO:0051553 ! flavone biosynthetic process

[Term]
id: GO:0033512
name: L-lysine catabolic process to acetyl-CoA via saccharopine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate saccharopine." [GOC:mah, MetaCyc:LYSINE-DEG1-PWY]
subset: gosubset_prok
synonym: "L-lysine breakdown to acetyl-CoA via saccharopine" EXACT []
synonym: "L-lysine degradation to acetyl-CoA via saccharopine" EXACT []
xref: MetaCyc:LYSINE-DEG1-PWY
is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA

[Term]
id: GO:0033513
name: L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate 5-aminopentanamide." [GOC:mah, MetaCyc:PWY-5280]
subset: gosubset_prok
synonym: "L-lysine breakdown to acetyl-CoA via 5-aminopentanamide" EXACT []
synonym: "L-lysine degradation to acetyl-CoA via 5-aminopentanamide" EXACT []
xref: MetaCyc:PWY-5280
is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA

[Term]
id: GO:0033514
name: L-lysine catabolic process to acetyl-CoA via L-pipecolate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate L-pipecolate." [GOC:mah, MetaCyc:PWY-5283]
subset: gosubset_prok
synonym: "L-lysine breakdown to acetyl-CoA via L-pipecolate" EXACT []
synonym: "L-lysine degradation to acetyl-CoA via L-pipecolate" EXACT []
xref: MetaCyc:PWY-5283
is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA

[Term]
id: GO:0033515
name: L-lysine catabolic process using lysine 6-aminotransferase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including alpha-aminoadipate; in this pathway, L-lysine is converted to 2-aminoadipate-6-semialdehyde by lysine 6-aminotransferase." [GOC:mah, MetaCyc:PWY-5298]
subset: gosubset_prok
synonym: "L-lysine breakdown using lysine 6-aminotransferase" EXACT [GOC:mah]
synonym: "L-lysine degradation using lysine 6-aminotransferase" EXACT [GOC:mah]
xref: MetaCyc:PWY-5298
is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA

[Term]
id: GO:0033516
name: L-methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-phospho-L-homoserine and cystathionine." [GOC:mah, MetaCyc:PWY-702]
subset: gosubset_prok
synonym: "L-methionine anabolism from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine formation from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "L-methionine synthesis from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
synonym: "methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah]
xref: MetaCyc:PWY-702
is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine

[Term]
id: GO:0033517
name: myo-inositol hexakisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds." [ChEBI:17401, PMID:16107538]
synonym: "myo-inositol hexakisphosphate metabolism" EXACT []
synonym: "phytate metabolic process" EXACT []
synonym: "phytate metabolism" EXACT []
is_a: GO:0043647 ! inositol phosphate metabolic process

[Term]
id: GO:0033518
name: myo-inositol hexakisphosphate dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphate group from myo-inositol hexakisphosphate." [GOC:mah]
synonym: "phytate dephosphorylation" EXACT []
xref: MetaCyc:PWY-4702
xref: MetaCyc:PWY-4781
is_a: GO:0033517 ! myo-inositol hexakisphosphate metabolic process
is_a: GO:0046855 ! inositol phosphate dephosphorylation

[Term]
id: GO:0033519
name: phytyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate." [ChEBI:18187, GOC:mah]
synonym: "phytyl diphosphate metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006721 ! terpenoid metabolic process
is_a: GO:0033306 ! phytol metabolic process

[Term]
id: GO:0033520
name: phytol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [ChEBI:17327, GOC:mah]
synonym: "phytol anabolism" EXACT []
synonym: "phytol biosynthesis" EXACT []
synonym: "phytol formation" EXACT []
synonym: "phytol synthesis" EXACT []
is_a: GO:0033306 ! phytol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0033521
name: phytyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate." [ChEBI:18187, GOC:mah]
synonym: "phytyl diphosphate anabolism" EXACT []
synonym: "phytyl diphosphate biosynthesis" EXACT []
synonym: "phytyl diphosphate formation" EXACT []
synonym: "phytyl diphosphate synthesis" EXACT []
xref: MetaCyc:PWY-5063
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016114 ! terpenoid biosynthetic process
is_a: GO:0033519 ! phytyl diphosphate metabolic process
is_a: GO:0033520 ! phytol biosynthetic process

[Term]
id: GO:0033522
name: histone H2A ubiquitination
namespace: biological_process
def: "The modification of histone H2A by addition of ubiquitin groups. Steady-state modification occurs at lysine 119 (H2A-K119) of metazoans or the equivalent residue; during double-strand break repair, modification may also occur at additional H2A lysine residues." [GOC:mah, PMID:15509584, PMID:16473935, PMID:18430235]
is_a: GO:0016574 ! histone ubiquitination

[Term]
id: GO:0033523
name: histone H2B ubiquitination
namespace: biological_process
def: "The modification of histone H2B by addition of ubiquitin groups." [GOC:mah]
is_a: GO:0016574 ! histone ubiquitination

[Term]
id: GO:0033524
name: sinapate ester metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ester derivatives of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [ChEBI:30023, GOC:mah]
synonym: "sinapate ester metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process

[Term]
id: GO:0033525
name: sinapate ester biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ester derivates of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [ChEBI:30023, GOC:mah]
synonym: "sinapate ester anabolism" EXACT []
synonym: "sinapate ester biosynthesis" EXACT []
synonym: "sinapate ester formation" EXACT []
synonym: "sinapate ester synthesis" EXACT []
xref: MetaCyc:PWY-3301
is_a: GO:0009699 ! phenylpropanoid biosynthetic process
is_a: GO:0033524 ! sinapate ester metabolic process

[Term]
id: GO:0033526
name: tetrapyrrole biosynthetic process from glutamate
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including L-glutamate." [ChEBI:26932, GOC:mah, MetaCyc:PWY-5188]
synonym: "tetrapyrrole anabolism from glutamate" EXACT []
synonym: "tetrapyrrole biosynthesis from glutamate" EXACT []
synonym: "tetrapyrrole formation from glutamate" EXACT []
synonym: "tetrapyrrole synthesis from glutamate" EXACT []
xref: MetaCyc:PWY-5188
is_a: GO:0033014 ! tetrapyrrole biosynthetic process

[Term]
id: GO:0033527
name: tetrapyrrole biosynthetic process from glycine and succinyl-CoA
namespace: biological_process
def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including glycine and succinyl-CoA." [ChEBI:26932, GOC:mah, MetaCyc:PWY-5189]
synonym: "tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT []
synonym: "tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT []
synonym: "tetrapyrrole formation from glycine and succinyl-CoA" EXACT []
synonym: "tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT []
xref: MetaCyc:PWY-5189
is_a: GO:0033014 ! tetrapyrrole biosynthetic process

[Term]
id: GO:0033528
name: S-methylmethionine cycle
namespace: biological_process
def: "A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine moiety of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level." [GOC:mah, MetaCyc:PWY-5441]
xref: MetaCyc:PWY-5441
is_a: GO:0033477 ! S-methylmethionine metabolic process

[Term]
id: GO:0033529
name: raffinose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [ChEBI:16634, GOC:mah]
synonym: "raffinose anabolism" EXACT []
synonym: "raffinose biosynthesis" EXACT []
synonym: "raffinose formation" EXACT []
synonym: "raffinose synthesis" EXACT []
is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process
is_a: GO:0033530 ! raffinose metabolic process

[Term]
id: GO:0033530
name: raffinose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [ChEBI:16634, GOC:mah]
synonym: "raffinose metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:0033531
name: stachyose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [ChEBI:17164, GOC:mah]
synonym: "stachyose metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:0033532
name: stachyose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [ChEBI:17164, GOC:mah]
synonym: "stachyose anabolism" EXACT []
synonym: "stachyose biosynthesis" EXACT []
synonym: "stachyose formation" EXACT []
synonym: "stachyose synthesis" EXACT []
xref: MetaCyc:PWY-5337
is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process
is_a: GO:0033531 ! stachyose metabolic process

[Term]
id: GO:0033533
name: verbascose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8065]
synonym: "verbascose metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:0033534
name: verbascose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8065]
synonym: "verbascose anabolism" EXACT []
synonym: "verbascose biosynthesis" EXACT []
synonym: "verbascose formation" EXACT []
synonym: "verbascose synthesis" EXACT []
is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process
is_a: GO:0033533 ! verbascose metabolic process

[Term]
id: GO:0033535
name: ajugose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8066]
synonym: "ajugose metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process

[Term]
id: GO:0033536
name: ajugose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8066]
synonym: "ajugose anabolism" EXACT []
synonym: "ajugose biosynthesis" EXACT []
synonym: "ajugose formation" EXACT []
synonym: "ajugose synthesis" EXACT []
is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process
is_a: GO:0033535 ! ajugose metabolic process

[Term]
id: GO:0033537
name: ajugose biosynthetic process using galactinol:raffinose galactosyltransferase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a ptahway in which galactinol:raffinose galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of galactinol to the oligosaccharide." [GOC:mah, MetaCyc:PWY-5342]
synonym: "ajugose anabolism using galactinol:raffinose galactosyltransferase" EXACT []
synonym: "ajugose biosynthesis using galactinol:raffinose galactosyltransferase" EXACT []
synonym: "ajugose formation using galactinol:raffinose galactosyltransferase" EXACT []
synonym: "ajugose synthesis using galactinol:raffinose galactosyltransferase" EXACT []
xref: MetaCyc:PWY-5342
is_a: GO:0033536 ! ajugose biosynthetic process

[Term]
id: GO:0033538
name: ajugose biosynthetic process using galactan:galactan galactosyltransferase
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactan:galactan galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of one raffinose-family oligosaccharide to another." [GOC:mah, MetaCyc:PWY-5343]
synonym: "ajugose anabolism using galactan:galactan galactosyltransferase" EXACT []
synonym: "ajugose biosynthesis using galactan:galactan galactosyltransferase" EXACT []
synonym: "ajugose formation using galactan:galactan galactosyltransferase" EXACT []
synonym: "ajugose synthesis using galactan:galactan galactosyltransferase" EXACT []
xref: MetaCyc:PWY-5343
is_a: GO:0033536 ! ajugose biosynthetic process

[Term]
id: GO:0033539
name: fatty acid beta-oxidation using acyl-CoA dehydrogenase
namespace: biological_process
def: "A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:FAO-PWY, MetaCyc:PWY-5136]
xref: MetaCyc:FAO-PWY
is_a: GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0033540
name: fatty acid beta-oxidation using acyl-CoA oxidase
namespace: biological_process
def: "A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce H2O2, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5136]
xref: MetaCyc:PWY-5136
xref: Reactome:389887 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:390247 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:448459 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:448585 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:469589 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:469714 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:487308 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:487426 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:507259 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:507382 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:517281 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:517382 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:526159 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:526259 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:531056 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:531132 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:536438 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:536506 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:542218 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:542219 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:552092 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:552180 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:557670 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:557765 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:568291 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:568377 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:581493 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:581579 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:592390 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:592474 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:597296 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:597297 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:598105 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:599649 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:599677 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:600695 "Beta-oxidation of very long chain fatty acids"
xref: Reactome:602391 "Beta-oxidation of pristanoyl-CoA"
xref: Reactome:602461 "Beta-oxidation of very long chain fatty acids"
is_a: GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0033541
name: fatty acid beta-oxidation, unsaturated, odd number
namespace: biological_process
def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on odd-numbered carbons are degraded. In this pathway, a cis-3-enoyl-CoA is generated by the core beta-oxidation pathway, and then converted to a trans-2-enoyl-CoA, which can return to the core beta-oxidation pathway for complete degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5137]
xref: MetaCyc:PWY-5137
is_a: GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0033542
name: fatty acid beta-oxidation, unsaturated, even number
namespace: biological_process
def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138]
xref: MetaCyc:PWY-5138
is_a: GO:0006635 ! fatty acid beta-oxidation

[Term]
id: GO:0033543
name: fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway
namespace: biological_process
def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to trans-2-enoyl-CoA by 2,4-dienoyl-CoA reductase and delta3-delta2-enoyl-CoA isomerase; trans-2-enoyl-CoA returns to the core beta-oxidation pathway for further degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138]
is_a: GO:0033542 ! fatty acid beta-oxidation, unsaturated, even number

[Term]
id: GO:0033544
name: fatty acid beta-oxidation, unsaturated, even number, epimerase pathway
namespace: biological_process
def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to cis-2-enoyl-CoA through one more cycle of the core beta-oxidation pathway. Cis-2-enoyl-CoA cannot be completely degraded via the core beta-oxidation pathway because hydratation of cis-2-enoyl-CoA yields D-3-hydroxyacyl-CoA, which is not a substrate for 3-hydroxylacyl-CoA dehydrogenase. Cis-2-enoyl-CoA must enter the so-called epimerase pathway, which involves converting D-3-hydroxyacyl-CoA to L-3-hydroxyacyl-CoA by 3-hydroxylacyl-CoA epimerase or by two stereo-specific enoyl-CoA hydratases. L-3-hydroxyacyl-CoA then returns to the core beta-oxidation pathway. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138]
is_a: GO:0033542 ! fatty acid beta-oxidation, unsaturated, even number

[Term]
id: GO:0033545
name: myo-inositol hexakisphosphate biosynthetic process, lipid-dependent
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C." [GOC:mah, MetaCyc:PWY-4765]
synonym: "myo-inositol hexakisphosphate anabolism, lipid-dependent" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthesis, lipid-dependent" EXACT []
synonym: "myo-inositol hexakisphosphate formation, lipid-dependent" EXACT []
synonym: "myo-inositol hexakisphosphate synthesis, lipid-dependent" EXACT []
synonym: "phytate biosynthesis, lipid-dependent" EXACT []
synonym: "phytate biosynthetic process, lipid-dependent" EXACT []
xref: MetaCyc:PWY-4765
is_a: GO:0010264 ! myo-inositol hexakisphosphate biosynthetic process

[Term]
id: GO:0033546
name: myo-inositol hexakisphosphate biosynthetic process, via inositol 1,3,4-trisphosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is first converted to inositol 1,3,4-trisphosphate, and then phosphorylated further." [GOC:mah, MetaCyc:PWY-4562]
synonym: "myo-inositol hexakisphosphate anabolism, via inositol 1,3,4-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthesis, via inositol 1,3,4-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate formation, via inositol 1,3,4-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate synthesis, via inositol 1,3,4-trisphosphate" EXACT []
synonym: "phytate biosynthesis, via inositol 1,3,4-trisphosphate" EXACT []
synonym: "phytate biosynthetic process, via inositol 1,3,4-trisphosphate" EXACT []
xref: MetaCyc:PWY-4562
is_a: GO:0033545 ! myo-inositol hexakisphosphate biosynthetic process, lipid-dependent

[Term]
id: GO:0033547
name: myo-inositol hexakisphosphate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is successively phosphorylated to yield inositol hexakisphosphate." [GOC:mah, MetaCyc:PWY-4541]
synonym: "myo-inositol hexakisphosphate anabolism, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate formation, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "myo-inositol hexakisphosphate synthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "phytate biosynthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
synonym: "phytate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT []
xref: MetaCyc:PWY-4541
is_a: GO:0033545 ! myo-inositol hexakisphosphate biosynthetic process, lipid-dependent

[Term]
id: GO:0033548
name: myo-inositol hexakisphosphate biosynthetic process, lipid-independent
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, by the successively phosphorylation of myo-inositol or an inositol trisphosphate; the inositol trisphosphates that may be used by this pathway are inositol 3,4,5-trisphosphate and inositol 3,4,6trisphosphate." [GOC:mah, MetaCyc:PWY-4661]
synonym: "myo-inositol hexakisphosphate anabolism, lipid-independent" EXACT []
synonym: "myo-inositol hexakisphosphate biosynthesis, lipid-independent" EXACT []
synonym: "myo-inositol hexakisphosphate formation, lipid-independent" EXACT []
synonym: "myo-inositol hexakisphosphate synthesis, lipid-independent" EXACT []
synonym: "phytate biosynthesis, lipid-independent" EXACT []
synonym: "phytate biosynthetic process, lipid-independent" EXACT []
xref: MetaCyc:PWY-4661
is_a: GO:0010264 ! myo-inositol hexakisphosphate biosynthetic process

[Term]
id: GO:0033549
name: MAP kinase phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate." [GOC:mah]
is_a: GO:0004721 ! phosphoprotein phosphatase activity

[Term]
id: GO:0033550
name: MAP kinase tyrosine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate." [GOC:mah]
synonym: "tyrosine-specific MAP kinase phosphatase activity" EXACT []
is_a: GO:0004725 ! protein tyrosine phosphatase activity
is_a: GO:0033549 ! MAP kinase phosphatase activity

[Term]
id: GO:0033551
name: monopolin complex
namespace: cellular_component
def: "A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits." [GOC:mah, GOC:rb, PMID:17627824]
synonym: "monopolin subcomplex Csm1/Lrs4" NARROW []
synonym: "Pcs1/Mde4 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000777 ! condensed chromosome kinetochore

[Term]
id: GO:0033552
name: response to vitamin B3
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus." [GOC:sl]
synonym: "response to niacin" NARROW []
synonym: "response to nicotinamide" NARROW []
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0033553
name: rDNA heterochromatin
namespace: cellular_component
def: "A region of heterochromatin located at the rDNA repeats in a chromosome." [GOC:mah]
synonym: "ribosomal DNA heterochromatin" EXACT []
is_a: GO:0000792 ! heterochromatin

[Term]
id: GO:0033554
name: cellular response to stress
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
is_a: GO:0006950 ! response to stress
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0033555
name: multicellular organismal response to stress
namespace: biological_process
def: "A change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah]
is_a: GO:0006950 ! response to stress
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0033556
name: dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(7)GlcNAc(2)-PP-Dol." [GOC:mah, PMID:10336995]
synonym: "dolichyl-P-Glc:Man7GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT []
xref: EC:2.4.1.-
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033557
name: Slx1-Slx4 complex
namespace: cellular_component
def: "A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377]
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0033558
name: protein deacetylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate." [GOC:mah]
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0033559
name: unsaturated fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah]
subset: gosubset_prok
synonym: "unsaturated fatty acid metabolism" EXACT []
xref: MetaCyc:PWY-762
xref: MetaCyc:PWY-782
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0033560
name: folate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+." [GOC:pd]
subset: gosubset_prok
xref: Reactome:201093 "folate reductase activity"
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033561
name: regulation of water loss via skin
namespace: biological_process
def: "A process that modulates the rate or extent of water loss from an organism via the skin." [GOC:mah]
synonym: "skin barrier function" RELATED []
is_a: GO:0050891 ! multicellular organismal water homeostasis

[Term]
id: GO:0033562
name: cotranscriptional gene silencing by small RNA
namespace: biological_process
def: "A process by which the targeting of nascent transcripts by the RITS complex mediates chromatin modifications and promotes the degradation of nascent transcripts synthesized in heterochromatic regions." [GOC:mah, PMID:17512405]
synonym: "small RNA-mediated cotranscriptional gene silencing" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031047 ! gene silencing by RNA

[Term]
id: GO:0033563
name: dorsal/ventral axon guidance
namespace: biological_process
def: "The process by which the migration of an axon growth cone is directed to a specific target site along the dorsal-ventral body axis in response to a combination of attractive and repulsive cues. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:kmv, GOC:tb]
synonym: "dorsal-ventral axon guidance" EXACT [GOC:mah]
synonym: "dorsal/ventral axon pathfinding" EXACT [GOC:mah]
synonym: "dorsoventral axon guidance" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0033564
name: anterior/posterior axon guidance
namespace: biological_process
def: "The process by which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:kmv, GOC:tb]
synonym: "anterior-posterior axon guidance" EXACT []
synonym: "anterior/posterior axon pathfinding" EXACT [GOC:mah]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0033565
name: ESCRT-0 complex
namespace: cellular_component
def: "A protein complex required for the recycling of Golgi proteins, formation of lumenal membranes and sorting of ubiquitinated proteins into those membranes. This complex includes Vps1p and Hse1p in yeast and the Hrs and STAM proteins in mammals." [GOC:rb, PMID:12055639, PMID:17543868]
synonym: "Hrs/STAM complex" EXACT []
synonym: "Vps27p-Hse1p complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044440 ! endosomal part

[Term]
id: GO:0033566
name: gamma-tubulin complex localization
namespace: biological_process
def: "Any process by which a gamma-tubulin complex is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "establishment and maintenance of gamma-tubulin complex localization" EXACT []
is_a: GO:0034629 ! cellular protein complex localization

[Term]
id: GO:0033567
name: DNA replication, Okazaki fragment processing
namespace: biological_process
def: "The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand." [GOC:mah, ISBN:0716720094]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006273 ! lagging strand elongation

[Term]
id: GO:0033568
name: lactoferrin receptor activity
namespace: molecular_function
def: "Combining with lactoferrin to initiate a change in cell activity." [GOC:mlg]
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0033569
name: lactoferrin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of lactoferrin from one side of a membrane to the other." [GOC:mlg]
is_a: GO:0015091 ! ferric iron transmembrane transporter activity
is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity

[Term]
id: GO:0033570
name: transferrin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of transferrin from one side of a membrane to the other." [GOC:mlg]
is_a: GO:0015091 ! ferric iron transmembrane transporter activity
is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity

[Term]
id: GO:0033571
name: lactoferrin transport
namespace: biological_process
def: "The directed movement of lactoferrin into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mlg]
is_a: GO:0015031 ! protein transport
is_a: GO:0015682 ! ferric iron transport

[Term]
id: GO:0033572
name: transferrin transport
namespace: biological_process
def: "The directed movement of transferrin into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mlg]
synonym: "melanotransferrin transport" EXACT [PRO:000001887]
is_a: GO:0015031 ! protein transport
is_a: GO:0015682 ! ferric iron transport

[Term]
id: GO:0033573
name: high affinity iron permease complex
namespace: cellular_component
def: "A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell." [GOC:jp, PMID:16522632, PMID:8599111]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0033574
name: response to testosterone stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:sl]
is_a: GO:0048545 ! response to steroid hormone stimulus

[Term]
id: GO:0033575
name: protein amino acid glycosylation at cell surface
namespace: biological_process
def: "The addition of a sugar unit to a protein amino acid at the surface of a cell." [GOC:mah, PMID:12042244]
is_a: GO:0006486 ! protein amino acid glycosylation

[Term]
id: GO:0033576
name: protein amino acid glycosylation in cytosol
namespace: biological_process
def: "The addition of a sugar unit to a protein amino acid in the cytosol." [GOC:mah, PMID:12042244]
is_a: GO:0006486 ! protein amino acid glycosylation

[Term]
id: GO:0033577
name: protein amino acid glycosylation in endoplasmic reticulum
namespace: biological_process
def: "The addition of a sugar unit to a protein amino acid in the endoplasmic reticulum." [GOC:mah, PMID:12042244]
synonym: "protein amino acid glycosylation in ER" EXACT []
is_a: GO:0006486 ! protein amino acid glycosylation

[Term]
id: GO:0033578
name: protein amino acid glycosylation in Golgi
namespace: biological_process
def: "The addition of a sugar unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:mah, PMID:12042244]
is_a: GO:0006486 ! protein amino acid glycosylation

[Term]
id: GO:0033579
name: protein amino acid galactosylation in endoplasmic reticulum
namespace: biological_process
def: "The addition of a galactose unit to a protein amino acid in the endoplasmic reticulum." [GOC:mah]
synonym: "protein amino acid galactosylation in ER" EXACT []
is_a: GO:0033577 ! protein amino acid glycosylation in endoplasmic reticulum
is_a: GO:0042125 ! protein amino acid galactosylation

[Term]
id: GO:0033580
name: protein amino acid galactosylation at cell surface
namespace: biological_process
def: "The addition of a galactose unit to a protein amino acid at the surface of a cell." [GOC:mah]
is_a: GO:0033575 ! protein amino acid glycosylation at cell surface
is_a: GO:0042125 ! protein amino acid galactosylation

[Term]
id: GO:0033581
name: protein amino acid galactosylation in Golgi
namespace: biological_process
def: "The addition of a galactose unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:mah]
is_a: GO:0033578 ! protein amino acid glycosylation in Golgi
is_a: GO:0042125 ! protein amino acid galactosylation

[Term]
id: GO:0033582
name: protein amino acid galactosylation in cytosol
namespace: biological_process
def: "The addition of a galactose unit to a protein amino acid in the cytosol." [GOC:mah]
is_a: GO:0033576 ! protein amino acid glycosylation in cytosol
is_a: GO:0042125 ! protein amino acid galactosylation

[Term]
id: GO:0033583
name: rhabdomere membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding the rhabdomere." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0016028 ! rhabdomere

[Term]
id: GO:0033584
name: tyrosine biosynthetic process from chorismate via L-arogenate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate L-arogenate." [GOC:mah, MetaCyc:PWY-3461]
subset: gosubset_prok
synonym: "tyrosine anabolism from chorismate via L-arogenate" EXACT []
synonym: "tyrosine formation from chorismate via L-arogenate" EXACT []
synonym: "tyrosine synthesis from chorismate via L-arogenate" EXACT []
xref: MetaCyc:PWY-3461
is_a: GO:0006571 ! tyrosine biosynthetic process

[Term]
id: GO:0033585
name: L-phenylalanine biosynthetic process from chorismate via phenylpyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate phenylpyruvate." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-phenylalanine anabolism from chorismate via phenylpyruvate" EXACT []
synonym: "L-phenylalanine biosynthesis from chorismate via phenylpyruvate" EXACT []
synonym: "L-phenylalanine formation from chorismate via phenylpyruvate" EXACT []
synonym: "L-phenylalanine synthesis from chorismate via phenylpyruvate" EXACT []
xref: MetaCyc:PHESYN
is_a: GO:0009094 ! L-phenylalanine biosynthetic process

[Term]
id: GO:0033586
name: L-phenylalanine biosynthetic process from chorismate via L-arogenate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate L-arogenate." [GOC:go_curators]
subset: gosubset_prok
synonym: "L-phenylalanine anabolism from chorismate via L-arogenate" EXACT []
synonym: "L-phenylalanine biosynthesis from chorismate via L-arogenate" EXACT []
synonym: "L-phenylalanine formation from chorismate via L-arogenate" EXACT []
synonym: "L-phenylalanine synthesis from chorismate via L-arogenate" EXACT []
xref: MetaCyc:PWY-3462
is_a: GO:0009094 ! L-phenylalanine biosynthetic process

[Term]
id: GO:0033587
name: shikimate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid." [ChEBI:36208, GOC:mah]
synonym: "shikimate anabolism" EXACT []
synonym: "shikimate biosynthesis" EXACT []
synonym: "shikimate formation" EXACT []
synonym: "shikimate synthesis" EXACT []
is_a: GO:0019632 ! shikimate metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0033588
name: Elongator holoenzyme complex
namespace: cellular_component
alt_id: GO:0033589
def: "A heterohexameric protein complex that is involved in tRNA modification, and exerts indirect effects on transcriptional elongation and exocytosis. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes." [GOC:mah, PMID:11689709, PMID:17018299]
synonym: "Elongator core complex" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0033590
name: response to cobalamin
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus." [GOC:sl]
synonym: "response to vitamin B12" EXACT []
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0033591
name: response to L-ascorbic acid
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus." [GOC:sl]
synonym: "response to ascorbic acid" BROAD []
synonym: "response to L-ascorbate" EXACT []
synonym: "response to vitamin C" EXACT []
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0033592
name: RNA strand annealing activity
namespace: molecular_function
def: "Facilitates the base-pairing of complementary single-stranded RNA." [GOC:mah]
is_a: GO:0003725 ! double-stranded RNA binding
is_a: GO:0003727 ! single-stranded RNA binding

[Term]
id: GO:0033593
name: BRCA2-MAGE-D1 complex
namespace: cellular_component
def: "A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth." [PMID:15930293]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0033594
name: response to hydroxyisoflavone
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus." [ChEBI:38755, GOC:mah]
is_a: GO:0014070 ! response to organic cyclic substance

[Term]
id: GO:0033595
name: response to genistein
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [ChEBI:28088, GOC:mah]
is_a: GO:0014070 ! response to organic cyclic substance

[Term]
id: GO:0033596
name: TSC1-TSC2 complex
namespace: cellular_component
def: "A heterodimeric protein complex consisting of tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway." [PMID:10585443, PMID:17121544, PMID:9580671]
synonym: "tuberin-hamartin complex " EXACT []
synonym: "tuberous sclerosis complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0033597
name: mitotic checkpoint complex
namespace: cellular_component
def: "A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20." [PMID:10704439, PMID:11535616, PMID:11726501, PMID:17650307]
synonym: "MCC" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0033598
name: mammary gland epithelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:mah]
is_a: GO:0050673 ! epithelial cell proliferation
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0033599
name: regulation of mammary gland epithelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation." [GOC:mah]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0033598 ! mammary gland epithelial cell proliferation

[Term]
id: GO:0033600
name: negative regulation of mammary gland epithelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of mammary gland epithelial cell proliferation." [GOC:mah]
synonym: "down regulation of mammary gland epithelial cell proliferation" EXACT []
synonym: "down-regulation of mammary gland epithelial cell proliferation" EXACT []
synonym: "downregulation of mammary gland epithelial cell proliferation" EXACT []
synonym: "inhibition of mammary gland epithelial cell proliferation" NARROW []
is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
relationship: negatively_regulates GO:0033598 ! mammary gland epithelial cell proliferation

[Term]
id: GO:0033601
name: positive regulation of mammary gland epithelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation." [GOC:mah]
synonym: "activation of mammary gland epithelial cell proliferation" NARROW []
synonym: "stimulation of mammary gland epithelial cell proliferation" NARROW []
synonym: "up regulation of mammary gland epithelial cell proliferation" EXACT []
synonym: "up-regulation of mammary gland epithelial cell proliferation" EXACT []
synonym: "upregulation of mammary gland epithelial cell proliferation" EXACT []
is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
relationship: positively_regulates GO:0033598 ! mammary gland epithelial cell proliferation

[Term]
id: GO:0033602
name: negative regulation of dopamine secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of dopamine." [GOC:sl]
synonym: "down regulation of dopamine secretion" EXACT []
synonym: "down-regulation of dopamine secretion" EXACT []
synonym: "downregulation of dopamine secretion" EXACT []
synonym: "inhibition of dopamine secretion" NARROW []
is_a: GO:0014059 ! regulation of dopamine secretion
is_a: GO:0033604 ! negative regulation of catecholamine secretion
relationship: negatively_regulates GO:0014046 ! dopamine secretion

[Term]
id: GO:0033603
name: positive regulation of dopamine secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine." [GOC:sl]
synonym: "activation of dopamine secretion" NARROW []
synonym: "stimulation of dopamine secretion" NARROW []
synonym: "up regulation of dopamine secretion" EXACT []
synonym: "up-regulation of dopamine secretion" EXACT []
synonym: "upregulation of dopamine secretion" EXACT []
is_a: GO:0014059 ! regulation of dopamine secretion
is_a: GO:0033605 ! positive regulation of catecholamine secretion
relationship: positively_regulates GO:0014046 ! dopamine secretion

[Term]
id: GO:0033604
name: negative regulation of catecholamine secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah]
synonym: "down regulation of catecholamine secretion" EXACT []
synonym: "down-regulation of catecholamine secretion" EXACT []
synonym: "downregulation of catecholamine secretion" EXACT []
synonym: "inhibition of catecholamine secretion" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0050433 ! regulation of catecholamine secretion
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051953 ! negative regulation of amine transport
relationship: negatively_regulates GO:0050432 ! catecholamine secretion

[Term]
id: GO:0033605
name: positive regulation of catecholamine secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah]
synonym: "activation of catecholamine secretion" NARROW []
synonym: "stimulation of catecholamine secretion" NARROW []
synonym: "up regulation of catecholamine secretion" EXACT []
synonym: "up-regulation of catecholamine secretion" EXACT []
synonym: "upregulation of catecholamine secretion" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0050433 ! regulation of catecholamine secretion
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051954 ! positive regulation of amine transport
relationship: positively_regulates GO:0050432 ! catecholamine secretion

[Term]
id: GO:0033606
name: chemokine receptor transport within lipid bilayer
namespace: biological_process
def: "The directed movement of a chemokine receptor within a lipid bilayer." [GOC:mah]
synonym: "chemokine receptor translocation within membrane" EXACT []
is_a: GO:0032594 ! protein transport within lipid bilayer

[Term]
id: GO:0033607
name: SOD1-Bcl-2 complex
namespace: cellular_component
def: "A heterodimeric protein complex formed of superoxide dismutase 1 and Bcl-2. Complex formation is thought to link superoxide dismutase to an apoptotic pathway." [PMID:15233914, PMID:16790527]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0033608
name: formyl-CoA transferase activity
namespace: molecular_function
def: "Catalysis of the reaction formyl-CoA + oxalate = formate + oxalyl-CoA." [EC:2.8.3.16, GOC:mlg]
synonym: "formyl-CoA oxalate CoA-transferase activity" EXACT [EC:2.8.3.16]
synonym: "formyl-CoA:oxalate CoA-transferase activity" EXACT [EC:2.8.3.16]
synonym: "formyl-coenzyme A transferase activity" EXACT [EC:2.8.3.16]
xref: EC:2.8.3.16
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0033609
name: oxalate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oxalate, the organic acid ethanedioate." [ChEBI:30623, GOC:mlg]
synonym: "ethanedioate metabolic process" EXACT []
synonym: "ethanedioic acid metabolic process" EXACT []
synonym: "oxalate metabolism" EXACT []
synonym: "oxalic acid metabolic process" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0033610
name: oxalate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of oxalate, the organic acid ethanedioate." [ChEBI:30623, GOC:mlg]
synonym: "ethanedioate biosynthetic process" EXACT []
synonym: "ethanedioic acid biosynthetic process" EXACT []
synonym: "oxalate anabolism" EXACT []
synonym: "oxalate biosynthesis" EXACT []
synonym: "oxalate formation" EXACT []
synonym: "oxalate synthesis" EXACT []
synonym: "oxalic acid biosynthetic process" EXACT []
is_a: GO:0033609 ! oxalate metabolic process
is_a: GO:0043650 ! dicarboxylic acid biosynthetic process

[Term]
id: GO:0033611
name: oxalate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of oxalate, the organic acid ethanedioate." [ChEBI:30623, GOC:mlg]
synonym: "ethanedioate catabolic process" EXACT []
synonym: "ethanedioic acid catabolic process" EXACT []
synonym: "oxalate breakdown" EXACT []
synonym: "oxalate catabolism" EXACT []
synonym: "oxalate degradation" EXACT []
synonym: "oxalic acid catabolic process" EXACT []
is_a: GO:0033609 ! oxalate metabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process

[Term]
id: GO:0033612
name: receptor serine/threonine kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor that possesses protein serine/threonine kinase activity." [GOC:mah]
synonym: "transmembrane receptor protein serine/threonine kinase ligand binding" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0033613
name: transcription activator binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a transcription activator, any protein whose activity is required to initiate or upregulate transcription." [GOC:mah]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0033614
name: chloroplast proton-transporting ATP synthase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the chloroplast thylakoid membrane." [GOC:mah]
is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly
relationship: part_of GO:0009658 ! chloroplast organization

[Term]
id: GO:0033615
name: mitochondrial proton-transporting ATP synthase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane." [GOC:mah]
is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly
relationship: part_of GO:0007005 ! mitochondrion organization

[Term]
id: GO:0033616
name: plasma membrane proton-transporting ATP synthase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the plasma membrane." [GOC:mah]
is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly
relationship: part_of GO:0007009 ! plasma membrane organization

[Term]
id: GO:0033617
name: mitochondrial respiratory chain complex IV assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah]
subset: gosubset_prok
synonym: "mitochondrial cytochrome c oxidase biogenesis" BROAD []
synonym: "mitochondrial cytochrome c oxidase complex assembly" EXACT []
is_a: GO:0008535 ! respiratory chain complex IV assembly
is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly

[Term]
id: GO:0033618
name: plasma membrane respiratory chain complex IV assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the plasma membrane." [GOC:mah]
subset: gosubset_prok
synonym: "plasma membrane cytochrome c oxidase biogenesis" BROAD []
synonym: "plasma membrane cytochrome c oxidase complex assembly" EXACT []
is_a: GO:0008535 ! respiratory chain complex IV assembly
relationship: part_of GO:0007009 ! plasma membrane organization

[Term]
id: GO:0033619
name: membrane protein proteolysis
namespace: biological_process
def: "The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains." [GOC:pd]
subset: gosubset_prok
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process

[Term]
id: GO:0033620
name: Mei2 nuclear dot
namespace: cellular_component
def: "A nuclear body that forms during meiotic prophase in a fixed position in the horsetail nucleus; contains Mei2 and meiRNA. May play a role in the progression of meiosis I." [PMID:12808043]
synonym: "Mei2 dot" EXACT []
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0033621
name: nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts
namespace: biological_process
def: "The chemical reactions and pathways resulting in the selective degradation of meiosis-specific transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein." [PMID:16823445]
comment: Note that it is speculated that higher eukaryotic YTH-family protein may be involved in similar mechanisms to supress gene regulation during gametogenesis or general silencing.
synonym: "degradation of meiosis-specific transcripts" EXACT []
synonym: "mRNA breakdown, meiosis-specific transcripts" EXACT []
synonym: "mRNA catabolism, meiosis-specific transcripts" EXACT []
synonym: "mRNA degradation, meiosis-specific transcripts" EXACT []
synonym: "nuclear mRNA catabolic process, meiosis-specific transcripts" EXACT []
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0033622
name: integrin activation
namespace: biological_process
def: "The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands." [GOC:add, PMID:12213832, PMID:14754902]
synonym: "integrin complex activation" EXACT []
synonym: "integrin complex assembly" EXACT []
is_a: GO:0006461 ! protein complex assembly

[Term]
id: GO:0033623
name: regulation of integrin activation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of integrin activation." [GOC:add]
synonym: "regulation of integrin complex activation" EXACT []
is_a: GO:0043254 ! regulation of protein complex assembly
relationship: regulates GO:0033622 ! integrin activation

[Term]
id: GO:0033624
name: negative regulation of integrin activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate, or extent of integrin activation." [GOC:add]
synonym: "negative regulation of integrin complex activation" EXACT []
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0033623 ! regulation of integrin activation
relationship: negatively_regulates GO:0033622 ! integrin activation

[Term]
id: GO:0033625
name: positive regulation of integrin activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of integrin activation." [GOC:add]
synonym: "positive regulation of integrin complex activation" EXACT []
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0033623 ! regulation of integrin activation
relationship: positively_regulates GO:0033622 ! integrin activation

[Term]
id: GO:0033626
name: cell surface receptor linked signal transduction leading to integrin activation
namespace: biological_process
def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell that lead to the increased affinity of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, for its extracellular ligands." [GOC:add, PMID:12213832, PMID:14754902]
synonym: "cell surface receptor linked signal transduction leading to integrin complex activation" EXACT []
is_a: GO:0007166 ! cell surface receptor linked signaling pathway

[Term]
id: GO:0033627
name: cell adhesion mediated by integrin
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]
synonym: "cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0007155 ! cell adhesion

[Term]
id: GO:0033628
name: regulation of cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add]
synonym: "regulation of cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0030155 ! regulation of cell adhesion
relationship: regulates GO:0033627 ! cell adhesion mediated by integrin

[Term]
id: GO:0033629
name: negative regulation of cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add]
synonym: "negative regulation of cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0007162 ! negative regulation of cell adhesion
is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin
relationship: negatively_regulates GO:0033627 ! cell adhesion mediated by integrin

[Term]
id: GO:0033630
name: positive regulation of cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add]
synonym: "positive regulation of cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin
is_a: GO:0045785 ! positive regulation of cell adhesion
relationship: positively_regulates GO:0033627 ! cell adhesion mediated by integrin

[Term]
id: GO:0033631
name: cell-cell adhesion mediated by integrin
namespace: biological_process
def: "The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902]
synonym: "cell-cell adhesion mediated by integrin complex " EXACT []
is_a: GO:0016337 ! cell-cell adhesion
is_a: GO:0033627 ! cell adhesion mediated by integrin

[Term]
id: GO:0033632
name: regulation of cell-cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add]
synonym: "regulation of cell-cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin
relationship: regulates GO:0033631 ! cell-cell adhesion mediated by integrin

[Term]
id: GO:0033633
name: negative regulation of cell-cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add]
synonym: "negative regulation of cell-cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0033629 ! negative regulation of cell adhesion mediated by integrin
is_a: GO:0033632 ! regulation of cell-cell adhesion mediated by integrin
relationship: negatively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin

[Term]
id: GO:0033634
name: positive regulation of cell-cell adhesion mediated by integrin
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add]
synonym: "positive regulation of cell-cell adhesion mediated by integrin complex" EXACT []
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0033630 ! positive regulation of cell adhesion mediated by integrin
is_a: GO:0033632 ! regulation of cell-cell adhesion mediated by integrin
relationship: positively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin

[Term]
id: GO:0033635
name: modulation by symbiont of host response to abiotic stimulus
namespace: biological_process
def: "Any process by which an organism modulates a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology

[Term]
id: GO:0033636
name: modulation by symbiont of host response to temperature stimulus
namespace: biological_process
def: "Any process by which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "modulation by symbiont of host response to thermal stimulus" EXACT []
is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus

[Term]
id: GO:0033637
name: modulation by symbiont of host response to cold
namespace: biological_process
def: "Any process by which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "freezing tolerance" RELATED []
is_a: GO:0033636 ! modulation by symbiont of host response to temperature stimulus

[Term]
id: GO:0033638
name: modulation by symbiont of host response to heat
namespace: biological_process
def: "Any process by which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "response to heat shock" RELATED []
is_a: GO:0033636 ! modulation by symbiont of host response to temperature stimulus

[Term]
id: GO:0033639
name: modulation by symbiont of host response to water
namespace: biological_process
def: "Any process by which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus

[Term]
id: GO:0033640
name: modulation by symbiont of host response to osmotic stress
namespace: biological_process
def: "Any process by which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus

[Term]
id: GO:0033641
name: modulation by symbiont of host response to pH
namespace: biological_process
def: "Any process by which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus

[Term]
id: GO:0033642
name: modulation by symbiont of host response to gravitational stimulus
namespace: biological_process
def: "Any process by which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "response to gravitational stimulus" BROAD []
is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus

[Term]
id: GO:0033643
name: host cell part
namespace: cellular_component
def: "Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0044217 ! other organism part
relationship: part_of GO:0043657 ! host cell

[Term]
id: GO:0033644
name: host cell membrane
namespace: cellular_component
def: "Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0033643 ! host cell part
is_a: GO:0044218 ! other organism cell membrane

[Term]
id: GO:0033645
name: host cell endomembrane system
namespace: cellular_component
def: "A collection of membranous structures involved in transport within the host cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033644 ! host cell membrane

[Term]
id: GO:0033646
name: host intracellular part
namespace: cellular_component
def: "Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
synonym: "host cell intracellular part" EXACT []
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0043656 ! intracellular region of host

[Term]
id: GO:0033647
name: host intracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring within the host cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0033646 ! host intracellular part

[Term]
id: GO:0033648
name: host intracellular membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
synonym: "host intracellular membrane-enclosed organelle" EXACT []
is_a: GO:0033647 ! host intracellular organelle

[Term]
id: GO:0033650
name: host cell mitochondrion
namespace: cellular_component
def: "A semiautonomous, self replicating organelle as found in host cells that occurs in varying numbers, shapes, and sizes in the cell cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "host mitochondria" EXACT []
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0033651
name: host cell plastid
namespace: cellular_component
def: "Any member of a family of organelles as found in the cytoplasm of host cells, which are membrane-bounded and contain DNA. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0033652
name: host cell chloroplast
namespace: cellular_component
def: "A chlorophyll-containing plastid as found within host cells with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033651 ! host cell plastid

[Term]
id: GO:0033653
name: host cell chloroplast part
namespace: cellular_component
def: "Any constituent part of a chloroplast as it is found in host cells and which are a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "host chloroplast component" EXACT []
is_a: GO:0033652 ! host cell chloroplast

[Term]
id: GO:0033654
name: host cell chloroplast thylakoid membrane
namespace: cellular_component
def: "Any sac-like membranous structures (cisternae) in a chloroplast found in host cells, combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033653 ! host cell chloroplast part
is_a: GO:0044160 ! host thylakoid membrane

[Term]
id: GO:0033655
name: host cell cytoplasm part
namespace: cellular_component
def: "Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
synonym: "cytoplasm component" BROAD []
is_a: GO:0033646 ! host intracellular part
relationship: part_of GO:0030430 ! host cell cytoplasm

[Term]
id: GO:0033656
name: modification by symbiont of host chloroplast
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of host cell chloroplasts. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0052043 ! modification by symbiont of host cellular component

[Term]
id: GO:0033657
name: modification by symbiont of host chloroplast part
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of a component of the host cell chloroplast. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033656 ! modification by symbiont of host chloroplast

[Term]
id: GO:0033658
name: modification by symbiont of host chloroplast thylakoid
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of the host cell chloroplast thylakoid. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033657 ! modification by symbiont of host chloroplast part

[Term]
id: GO:0033659
name: modification by symbiont of host mitochondrion
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of host cell mitochondria. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0052043 ! modification by symbiont of host cellular component

[Term]
id: GO:0033660
name: negative regulation by symbiont of host resistance gene-dependent defense response
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "down regulation by symbiont of defense response in host by specific elicitors" EXACT []
synonym: "down-regulation by symbiont of host gene-for-gene resistance" EXACT []
synonym: "downregulation by symbiont of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT []
synonym: "inhibition by symbiont of host resistance gene-dependent defense response" NARROW []
synonym: "suppression by symbiont of host resistance gene-dependent defense response" EXACT []
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052158 ! modulation by symbiont of host resistance gene-dependent defense response

[Term]
id: GO:0033661
name: negative regulation by symbiont of defense-related host reactive oxygen species production
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "down regulation by organism of defense-related host metabolic burst" EXACT []
synonym: "down-regulation by organism of defense-related host oxidative burst" EXACT []
synonym: "downregulation by organism of defense-related host AOS production" EXACT []
synonym: "inhibition by organism of defense-related host active oxygen species production" NARROW []
synonym: "negative regulation by organism of defense-related host reactive oxidative species production" EXACT []
synonym: "negative regulation by organism of defense-related host reactive oxygen intermediate production" EXACT []
synonym: "negative regulation by organism of defense-related host respiratory burst" EXACT []
synonym: "negative regulation by organism of defense-related host ROI production" EXACT []
synonym: "negative regulation by organism of defense-related host ROS production" EXACT []
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052164 ! modulation by symbiont of defense-related host reactive oxygen species production

[Term]
id: GO:0033662
name: modulation by symbiont of host defense-related protein level
namespace: biological_process
def: "The alternation by a symbiont of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0075344 ! modulation by symbiont of host protein levels

[Term]
id: GO:0033663
name: negative regulation by symbiont of host defense-related protein level
namespace: biological_process
def: "Any process by which the symbiont stops or reduces of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033662 ! modulation by symbiont of host defense-related protein level
is_a: GO:0052037 ! negative regulation by symbiont of host defense response

[Term]
id: GO:0033664
name: positive regulation by symbiont of host defense-related protein level
namespace: biological_process
def: "Any process by which the symbiont activates, maintains or increases levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0033662 ! modulation by symbiont of host defense-related protein level
is_a: GO:0052509 ! positive regulation by symbiont of host defense response

[Term]
id: GO:0033665
name: regulation of growth or development of symbiont in host
namespace: biological_process
def: "OBSOLETE. Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:dph, GOC:pamgo_curators, GOC:tb]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'regulation of development of symbiont in host ; GO:0044127' and 'regulation of growth of symbiont in host ; GO:0044126'.
synonym: "modulation of growth or development of organism within host" EXACT []
synonym: "modulation of growth or development of symbiont within host" EXACT [GOC:dph, GOC:tb]
synonym: "modulation of invasive growth" BROAD []
synonym: "regulation of growth or development of symbiont within host" EXACT []
is_obsolete: true
replaced_by: GO:0044126
replaced_by: GO:0044127

[Term]
id: GO:0033666
name: positive regulation of growth or development of symbiont in host
namespace: biological_process
def: "OBSOLETE. Any process by which the symbiont activates, maintains or increases its size or mass or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'positive regulation of development of symbiont in host ; GO:0044129' and 'positive regulation of growth of symbiont in host ; GO:0044128'.
synonym: "positive regulation of growth or development of symbiont within host" EXACT []
synonym: "positive regulation of invasive growth" BROAD []
synonym: "up regulation of growth or development of organism within host" EXACT []
synonym: "up-regulation of growth or development of organism within host" EXACT []
synonym: "upregulation of growth or development of organism within host" EXACT []
is_obsolete: true
replaced_by: GO:0044128
replaced_by: GO:0044129

[Term]
id: GO:0033667
name: negative regulation of growth or development of symbiont in host
namespace: biological_process
def: "OBSOLETE. Any process by which the symbiont stops, prevents or reduces its increase in size or mass or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'negative regulation of development of symbiont in host ; GO:0044131' and 'negative regulation of growth of symbiont in host ; GO:0044130'.
synonym: "down regulation of growth or development of organism within host" EXACT []
synonym: "down-regulation of growth or development of organism within host" EXACT []
synonym: "downregulation of growth or development of organism within host" EXACT []
synonym: "inhibition of growth of development of organism within host" NARROW []
synonym: "negative regulation of growth or development of symbiont within host" EXACT []
synonym: "negative regulation of invasive growth" BROAD []
is_obsolete: true
replaced_by: GO:0044130
replaced_by: GO:0044131

[Term]
id: GO:0033668
name: negative regulation by symbiont of host apoptosis
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of apoptosis ; GO:0043066'.
synonym: "down regulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "down-regulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "downregulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "inhibition by organism of host apoptotic programmed cell death" NARROW []
is_a: GO:0043066 ! negative regulation of apoptosis
is_a: GO:0052041 ! negative regulation by symbiont of host programmed cell death
is_a: GO:0052150 ! modulation by symbiont of host apoptosis

[Term]
id: GO:0033670
name: regulation of NAD+ kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah]
synonym: "NAD kinase regulator" NARROW []
synonym: "regulation of NAD kinase activity" EXACT []
is_a: GO:0043549 ! regulation of kinase activity

[Term]
id: GO:0033671
name: negative regulation of NAD+ kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah]
synonym: "down regulation of NAD+ kinase activity" EXACT []
synonym: "down-regulation of NAD+ kinase activity" EXACT []
synonym: "downregulation of NAD+ kinase activity" EXACT []
synonym: "inhibition of NAD+ kinase activity" NARROW []
synonym: "NAD+ kinase inhibitor" NARROW []
is_a: GO:0033670 ! regulation of NAD+ kinase activity
is_a: GO:0033673 ! negative regulation of kinase activity

[Term]
id: GO:0033672
name: positive regulation of NAD+ kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah]
synonym: "NAD+ kinase activator" NARROW []
synonym: "stimulation of NAD+ kinase activity" NARROW []
synonym: "up regulation of NAD+ kinase activity" EXACT []
synonym: "up-regulation of NAD+ kinase activity" EXACT []
synonym: "upregulation of NAD+ kinase activity" EXACT []
is_a: GO:0033670 ! regulation of NAD+ kinase activity
is_a: GO:0033674 ! positive regulation of kinase activity

[Term]
id: GO:0033673
name: negative regulation of kinase activity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]
synonym: "down regulation of kinase activity" EXACT []
synonym: "down-regulation of kinase activity" EXACT []
synonym: "downregulation of kinase activity" EXACT []
synonym: "inhibition of kinase activity" NARROW []
synonym: "kinase inhibitor" NARROW []
is_a: GO:0043549 ! regulation of kinase activity
is_a: GO:0051348 ! negative regulation of transferase activity

[Term]
id: GO:0033674
name: positive regulation of kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah]
synonym: "kinase activator" NARROW []
synonym: "stimulation of kinase activity" NARROW []
synonym: "up regulation of kinase activity" EXACT []
synonym: "up-regulation of kinase activity" EXACT []
synonym: "upregulation of kinase activity" EXACT []
is_a: GO:0043549 ! regulation of kinase activity
is_a: GO:0051347 ! positive regulation of transferase activity

[Term]
id: GO:0033675
name: pericanalicular vesicle
namespace: cellular_component
def: "A membrane-bounded vesicle found near the apical, or pericanalicular, membrane of a hepatocyte; contains proteins involved in bile salt transport and other fluid and solute transport processes." [PMID:15763347, PMID:9790571]
is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0033676
name: double-stranded DNA-dependent ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of double-stranded DNA; drives another reaction." [GOC:mah]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "dsDNA-dependent ATPase activity" EXACT []
is_a: GO:0008094 ! DNA-dependent ATPase activity

[Term]
id: GO:0033677
name: DNA/RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA." [GOC:mah]
comment: Consider also annotating to the molecular function term 'RNA binding ; GO:0003723'.
subset: gosubset_prok
xref: EC:2.7.7.-
is_a: GO:0004386 ! helicase activity

[Term]
id: GO:0033678
name: 5'-3' DNA/RNA helicase activity
namespace: molecular_function
def: "Catalysis of the unwinding of a DNA/RNA duplex in the direction 5' to 3'." [GOC:mah]
synonym: "5' to 3' DNA/RNA helicase activity" EXACT []
is_a: GO:0033677 ! DNA/RNA helicase activity

[Term]
id: GO:0033679
name: 3'-5' DNA/RNA helicase activity
namespace: molecular_function
def: "Catalysis of the unwinding of a DNA/RNA duplex in the direction 3' to 5'." [GOC:mah]
synonym: "3' to 5' DNA/RNA helicase activity" EXACT []
is_a: GO:0033677 ! DNA/RNA helicase activity

[Term]
id: GO:0033680
name: ATP-dependent DNA/RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of a DNA/RNA duplex." [GOC:mah]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
is_a: GO:0008026 ! ATP-dependent helicase activity
is_a: GO:0008094 ! DNA-dependent ATPase activity
is_a: GO:0033677 ! DNA/RNA helicase activity

[Term]
id: GO:0033681
name: ATP-dependent 3'-5' DNA/RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of a DNA/RNA duplex in the direction 3' to 5'." [GOC:mah]
synonym: "ATP-dependent 3' to 5' DNA/RNA helicase activity" EXACT []
is_a: GO:0033679 ! 3'-5' DNA/RNA helicase activity
is_a: GO:0033680 ! ATP-dependent DNA/RNA helicase activity

[Term]
id: GO:0033682
name: ATP-dependent 5'-3' DNA/RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of a DNA/RNA duplex in the direction 5' to 3'." [GOC:mah]
synonym: "ATP-dependent 5' to 3' DNA/RNA helicase activity" EXACT []
is_a: GO:0033678 ! 5'-3' DNA/RNA helicase activity
is_a: GO:0033680 ! ATP-dependent DNA/RNA helicase activity

[Term]
id: GO:0033683
name: nucleotide-excision repair, DNA incision
namespace: biological_process
def: "A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound." [GOC:elh, PMID:8631896]
subset: gosubset_prok
is_a: GO:0000737 ! DNA catabolic process, endonucleolytic
relationship: part_of GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0033684
name: regulation of luteinizing hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah]
is_a: GO:0032276 ! regulation of gonadotropin secretion
relationship: regulates GO:0032275 ! luteinizing hormone secretion

[Term]
id: GO:0033685
name: negative regulation of luteinizing hormone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah]
synonym: "down regulation of luteinizing hormone secretion" EXACT []
synonym: "down-regulation of luteinizing hormone secretion" EXACT []
synonym: "downregulation of luteinizing hormone secretion" EXACT []
synonym: "inhibition of luteinizing hormone secretion" NARROW []
is_a: GO:0032277 ! negative regulation of gonadotropin secretion
is_a: GO:0033684 ! regulation of luteinizing hormone secretion
relationship: negatively_regulates GO:0032275 ! luteinizing hormone secretion

[Term]
id: GO:0033686
name: positive regulation of luteinizing hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah]
synonym: "activation of luteinizing hormone secretion" NARROW []
synonym: "stimulation of luteinizing hormone secretion" NARROW []
synonym: "up regulation of luteinizing hormone secretion" EXACT []
synonym: "up-regulation of luteinizing hormone secretion" EXACT []
synonym: "upregulation of luteinizing hormone secretion" EXACT []
is_a: GO:0032278 ! positive regulation of gonadotropin secretion
is_a: GO:0033684 ! regulation of luteinizing hormone secretion
relationship: positively_regulates GO:0032275 ! luteinizing hormone secretion

[Term]
id: GO:0033687
name: osteoblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:mah]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0033688
name: regulation of osteoblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of osteoblast proliferation." [GOC:mah]
is_a: GO:0042127 ! regulation of cell proliferation
relationship: regulates GO:0033687 ! osteoblast proliferation

[Term]
id: GO:0033689
name: negative regulation of osteoblast proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation." [GOC:mah]
synonym: "down regulation of osteoblast proliferation" EXACT []
synonym: "down-regulation of osteoblast proliferation" EXACT []
synonym: "downregulation of osteoblast proliferation" EXACT []
synonym: "inhibition of osteoblast proliferation" NARROW []
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0033688 ! regulation of osteoblast proliferation
relationship: negatively_regulates GO:0033687 ! osteoblast proliferation

[Term]
id: GO:0033690
name: positive regulation of osteoblast proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of osteoblast proliferation." [GOC:mah]
synonym: "activation of osteoblast proliferation" NARROW []
synonym: "stimulation of osteoblast proliferation" NARROW []
synonym: "up regulation of osteoblast proliferation" EXACT []
synonym: "up-regulation of osteoblast proliferation" EXACT []
synonym: "upregulation of osteoblast proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0033688 ! regulation of osteoblast proliferation
relationship: positively_regulates GO:0033687 ! osteoblast proliferation

[Term]
id: GO:0033691
name: sialic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with sialic acid, any of a variety of N- or O- substituted derivatives of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria." [ChEBI:26667, GOC:add, http://www.biology-online.org, ISBN:0721601465]
synonym: "N-acetylneuraminic acid binding" NARROW []
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0033692
name: cellular polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, occurring at the level of an individual cell." [GOC:go_curators]
subset: gosubset_prok
synonym: "cellular glycan biosynthesis" EXACT []
synonym: "cellular glycan biosynthetic process" EXACT []
synonym: "cellular polysaccharide anabolism" EXACT []
synonym: "cellular polysaccharide biosynthesis" EXACT []
synonym: "cellular polysaccharide formation" EXACT []
synonym: "cellular polysaccharide synthesis" EXACT []
is_a: GO:0000271 ! polysaccharide biosynthetic process
is_a: GO:0034637 ! cellular carbohydrate biosynthetic process
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0033693
name: neurofilament bundle assembly
namespace: biological_process
def: "The assembly of neurofilaments into bundles, in which the filaments are longitudinally oriented, with numerous crossbridges between them. Neurofilament bundles may be cross-linked to each other, to membrane-bounded organelles or other cytoskeletal structures such as microtubules." [PMID:11034913, PMID:11264295]
synonym: "NF bundle assembly" EXACT []
is_a: GO:0045110 ! intermediate filament bundle assembly
is_a: GO:0060052 ! neurofilament cytoskeleton organization

[Term]
id: GO:0033694
name: oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]
subset: gosubset_prok
xref: EC:1.5.7
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0033695
name: oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule." [EC:1.17.5, GOC:mah]
subset: gosubset_prok
xref: EC:1.17.5
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0033696
name: negative regulation of extent of heterochromatin formation
namespace: biological_process
def: "Any process that reduces the extent of heterochromatin formation; reduces the size of a chromosomal region converted to heterochromatin." [GOC:mah]
synonym: "maintenance of heterochromatin boundaries" RELATED []
synonym: "negative regulation of heterochromatin spreading" RELATED []
is_a: GO:0031452 ! negative regulation of heterochromatin formation
is_a: GO:0031454 ! regulation of extent of heterochromatin formation

[Term]
id: GO:0033697
name: positive regulation of extent of heterochromatin formation
namespace: biological_process
def: "Any process that increases the extent of heterochromatin formation; increases the size of a chromosomal region converted to heterochromatin." [GOC:mah]
synonym: "positive regulation of heterochromatin spreading" RELATED []
is_a: GO:0031453 ! positive regulation of heterochromatin formation
is_a: GO:0031454 ! regulation of extent of heterochromatin formation

[Term]
id: GO:0033698
name: Rpd3L complex
namespace: cellular_component
alt_id: GO:0000508
def: "A histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae)." [GOC:vw, PMID:17450151]
synonym: "Clr6 histone deacetylase complex I/I'" EXACT [GOC:rb, GOC:vw]
synonym: "Clr6L complex" EXACT [PMID:19040720]
synonym: "Rpd3C(L)" EXACT []
is_a: GO:0070822 ! Sin3-type complex

[Term]
id: GO:0033699
name: DNA 5'-adenosine monophosphate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus." [GOC:mah, PMID:16547001, PMID:17276982]
synonym: "AMP-removal activity" RELATED []
synonym: "DNA 5'-adenylate hydrolase activity" EXACT []
synonym: "DNA adenylate hydrolysis activity" BROAD []
synonym: "DNA de-adenylation" RELATED []
synonym: "DNA deadenylation" RELATED []
is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity

[Term]
id: GO:0033700
name: phospholipid efflux
namespace: biological_process
def: "The directed movement of a phospholipid out of a cell or organelle." [GOC:mah]
synonym: "phospholipid export" EXACT []
is_a: GO:0015914 ! phospholipid transport

[Term]
id: GO:0033701
name: dTDP-galactose 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+." [EC:1.1.1.186]
synonym: "dTDP-D-galactose:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.186]
synonym: "dTDPgalactose 6-dehydrogenase activity" EXACT [EC:1.1.1.186]
synonym: "thymidine-diphosphate-galactose dehydrogenase activity" EXACT [EC:1.1.1.186]
xref: EC:1.1.1.186
xref: MetaCyc:DTDP-GALACTOSE-6-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033702
name: (+)-trans-carveol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-trans-carveol + NAD+ = (+)-(S)-carvone + NADH + H+." [EC:1.1.1.275]
synonym: "(+)-trans-carveol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.275]
xref: EC:1.1.1.275
xref: MetaCyc:RXN-9397
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033703
name: 3beta-hydroxy-5beta-steroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnan-3,20-dione + NADPH + H+." [EC:1.1.1.277]
synonym: "3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.277]
synonym: "3beta-hydroxysteroid 5beta-oxidoreductase activity" EXACT [EC:1.1.1.277]
synonym: "3beta-hydroxysteroid 5beta-progesterone oxidoreductase activity" EXACT [EC:1.1.1.277]
xref: EC:1.1.1.277
xref: MetaCyc:1.1.1.277-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033704
name: 3beta-hydroxy-5alpha-steroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ = 5alpha-pregnan-3,20-dione + NADPH + H+." [EC:1.1.1.278]
synonym: "3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.278]
xref: EC:1.1.1.278
xref: MetaCyc:1.1.1.278-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033705
name: GDP-4-dehydro-6-deoxy-D-mannose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+." [EC:1.1.1.281]
comment: Note that this enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-D-rhamnose (GDP-6-deoxy-D-mannose).
synonym: "GDP-4-keto-6-deoxy-D-mannose reductase activity" BROAD [EC:1.1.1.281]
synonym: "GDP-6-deoxy-D-lyxo-4-hexulose reductase activity" EXACT [EC:1.1.1.281]
synonym: "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) activity" EXACT [EC:1.1.1.281]
synonym: "Rmd" RELATED [EC:1.1.1.281]
xref: EC:1.1.1.281
xref: MetaCyc:GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033706
name: quinate/shikimate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reactions: L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H + H+ and shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H + H+." [EC:1.1.1.282]
synonym: "L-quinate:NAD(P)+ 3-oxidoreductase activity" EXACT [EC:1.1.1.282]
synonym: "YdiB" RELATED [EC:1.1.1.282]
xref: EC:1.1.1.282
xref: MetaCyc:RXN-7967
xref: MetaCyc:RXN-7968
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033707
name: 3''-deamino-3''-oxonicotianamine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxymugineic acid + NAD(P)+ = 3''-deamino-3''-oxonicotianamine + NAD(P)H + H+." [EC:1.1.1.285]
synonym: "2'-deoxymugineic acid:NAD(P)+ 3''-oxidoreductase activity" EXACT [EC:1.1.1.285]
xref: EC:1.1.1.285
xref: MetaCyc:1.1.1.285-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033708
name: isocitrate-homoisocitrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reactions: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH and (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+." [EC:1.1.1.286]
synonym: "homoisocitrate-isocitrate dehydrogenase activity" EXACT [EC:1.1.1.286]
synonym: "isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.286]
synonym: "PH1722" RELATED [EC:1.1.1.286]
xref: EC:1.1.1.286
xref: MetaCyc:RXN-7969
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033709
name: D-arabinitol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reactions: D-arabinitol + NADP+ = D-xylulose + NADPH + H+ and D-arabinitol + NADP+ = D-ribulose + NADPH + H+." [EC:1.1.1.287]
synonym: "ARD1p" RELATED [EC:1.1.1.287]
synonym: "D-arabinitol dehydrogenase 1 activity" NARROW [EC:1.1.1.287]
synonym: "D-arabinitol:NADP+ dehydrogenase activity" EXACT [EC:1.1.1.287]
synonym: "NADP+-dependent D-arabinitol dehydrogenase activity" EXACT [EC:1.1.1.287]
xref: EC:1.1.1.287
xref: MetaCyc:RXN-7971
xref: MetaCyc:RXN-7972
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033711
name: 4-phosphoerythronate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-phospho-D-erythronate + NAD+ = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + NADH + H+." [EC:1.1.1.290]
synonym: "4-O-phosphoerythronate dehydrogenase activity" EXACT [EC:1.1.1.290]
synonym: "4-phospho-D-erythronate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.290]
synonym: "4PE dehydrogenase activity" EXACT [EC:1.1.1.290]
synonym: "erythronate-4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.290]
synonym: "PdxB" RELATED [EC:1.1.1.290]
synonym: "PdxB 4PE dehydrogenase activity" EXACT [EC:1.1.1.290]
xref: EC:1.1.1.290
xref: MetaCyc:ERYTHRON4PDEHYDROG-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033712
name: 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,5-anhydro-D-mannitol + NADP+ = 1,5-anhydro-D-fructose + NADPH + H+." [EC:1.1.1.292]
synonym: "1,5-anhydro-D-mannitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.292]
synonym: "AFR" RELATED [EC:1.1.1.292]
xref: EC:1.1.1.292
xref: MetaCyc:1.1.1.292-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033713
name: choline:oxygen 1-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: choline + O2 = betaine aldehyde + H2O2." [EC:1.1.3.17]
synonym: "choline oxidase activity" BROAD [EC:1.1.3.17]
xref: EC:1.1.3.17
xref: MetaCyc:CHOLINE-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0033714
name: secondary-alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a secondary alcohol + O2 = a ketone + H2O2." [EC:1.1.3.18]
synonym: "polyvinyl alcohol oxidase activity" EXACT [EC:1.1.3.18]
synonym: "secondary alcohol oxidase activity" EXACT [EC:1.1.3.18]
synonym: "secondary-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.18]
xref: EC:1.1.3.18
xref: MetaCyc:SECONDARY-ALCOHOL-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0033715
name: nucleoside oxidase activity
namespace: molecular_function
def: "Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O and (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O." [EC:1.1.3.28]
synonym: "nucleoside:oxygen 5'-oxidoreductase activity" EXACT [EC:1.1.3.28]
xref: EC:1.1.3.28
xref: MetaCyc:NUCLEOSIDE-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0033716
name: nucleoside oxidase (H2O2-forming) activity
namespace: molecular_function
def: "Catalysis of the reactions: adenosine + 2 O2 = 9-riburonosyladenine + 2 H2O2, (1a) adenosine + O2 = 5'-dehydroadenosine + H2O2 and (1b) 5'-dehydroadenosine + O2 = 9-riburonosyladenine + H2O2." [EC:1.1.3.39]
synonym: "nucleoside:oxygen 5'-oxidoreductase (H2O2-forming) activity" EXACT [EC:1.1.3.39]
xref: EC:1.1.3.39
xref: MetaCyc:1.1.3.39-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0033717
name: gluconate 2-dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor." [EC:1.1.99.3]
synonym: "2-ketogluconate reductase activity" BROAD [EC:1.1.99.3]
synonym: "D-gluconate dehydrogenase activity" EXACT [EC:1.1.99.3]
synonym: "D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding activity" EXACT [EC:1.1.99.3]
synonym: "D-gluconate:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.3]
synonym: "D-gluconate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.3]
synonym: "gluconate oxidase activity" EXACT [EC:1.1.99.3]
synonym: "gluconic acid dehydrogenase activity" EXACT [EC:1.1.99.3]
synonym: "gluconic dehydrogenase activity" EXACT [EC:1.1.99.3]
xref: EC:1.1.99.3
xref: MetaCyc:GLUCONATE-2-DEHYDROGENASE-RXN
is_a: GO:0008875 ! gluconate dehydrogenase activity

[Term]
id: GO:0033718
name: pyranose dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reactions: pyranose + acceptor = 2-dehydropyranose (or 3-dehydropyranose or 2,3-didehydropyranose) + reduced acceptor and a pyranoside + acceptor = a 3-dehydropyranoside (or 3,4-didehydropyranoside) + reduced acceptor." [EC:1.1.99.29]
synonym: "PDH" RELATED [EC:1.1.99.29]
synonym: "pyranose dehydrogenase activity" EXACT [EC:1.1.99.29]
synonym: "pyranose-quinone oxidoreductase activity" EXACT [EC:1.1.99.29]
synonym: "pyranose:acceptor oxidoreductase activity" EXACT [EC:1.1.99.29]
synonym: "quinone-dependent pyranose dehydrogenase activity" EXACT [EC:1.1.99.29]
xref: EC:1.1.99.29
xref: MetaCyc:RXN-7961
xref: MetaCyc:RXN-7962
xref: MetaCyc:RXN-7963
xref: MetaCyc:RXN-7965
xref: MetaCyc:RXN-7966
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0033719
name: 2-oxo-acid reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor." [EC:1.1.99.30]
synonym: "(2R)-hydroxy-carboxylate:acceptor oxidoreductase activity" EXACT [EC:1.1.99.30]
synonym: "(2R)-hydroxycarboxylate-viologen-oxidoreductase activity" EXACT [EC:1.1.99.30]
synonym: "2-oxoacid reductase activity" EXACT [EC:1.1.99.30]
synonym: "HVOR" RELATED [EC:1.1.99.30]
xref: EC:1.1.99.30
xref: MetaCyc:1.1.99.30-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0033720
name: (S)-mandelate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor." [EC:1.1.99.31]
synonym: "(S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.31]
synonym: "L(+)-mandelate dehydrogenase activity" EXACT [EC:1.1.99.31]
synonym: "MDH" RELATED [EC:1.1.99.31]
xref: EC:1.1.99.31
xref: MetaCyc:MANDELATE-DEHYDROGENASE-RXN
xref: MetaCyc:MANDELATE-OXY-RXN
xref: UM-BBD_enzymeID:e0651
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0033721
name: aldehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+." [EC:1.2.1.4]
synonym: "aldehyde:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.4]
synonym: "NADP-acetaldehyde dehydrogenase activity" EXACT [EC:1.2.1.4]
synonym: "NADP-dependent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.4]
xref: EC:1.2.1.4
xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033722
name: malonate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+." [EC:1.2.1.15]
synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.15]
synonym: "malonic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.15]
xref: EC:1.2.1.15
xref: MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033723
name: fluoroacetaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+." [EC:1.2.1.69]
synonym: "fluoroacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.69]
xref: EC:1.2.1.69
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033726
name: aldehyde ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin." [EC:1.2.7.5]
synonym: "aldehyde:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.5]
synonym: "AOR" RELATED [EC:1.2.7.5]
synonym: "tungsten-containing aldehyde ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.5]
xref: EC:1.2.7.5
xref: MetaCyc:1.2.7.5-RXN
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0033727
name: aldehyde dehydrogenase (FAD-independent) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor." [EC:1.2.99.7]
synonym: "aldehyde oxidoreductase activity" EXACT [EC:1.2.99.7]
synonym: "aldehyde:acceptor oxidoreductase (FAD-independent) activity" EXACT [EC:1.2.99.7]
synonym: "AORDd" RELATED [EC:1.2.99.7]
synonym: "Mop" RELATED [EC:1.2.99.7]
xref: EC:1.2.99.7
xref: MetaCyc:1.2.99.3-RXN
xref: MetaCyc:1.2.99.7-RXN
xref: MetaCyc:CARBOXYLATE-REDUCTASE-RXN
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0033728
name: divinyl chlorophyllide a 8-vinyl-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlorophyllide a + NADP+ = divinyl chlorophyllide a + NADPH + H+." [EC:1.3.1.75]
synonym: "4VCR" RELATED [EC:1.3.1.75]
synonym: "[4-vinyl]chlorophyllide a reductase activity" EXACT [EC:1.3.1.75]
synonym: "chlorophyllide-a:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.75]
xref: EC:1.3.1.75
xref: MetaCyc:RXN-5286
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033729
name: anthocyanidin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+." [EC:1.3.1.77]
synonym: "ANR" RELATED [EC:1.3.1.77]
synonym: "AtANR" RELATED [EC:1.3.1.77]
synonym: "flavan-3-ol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.77]
synonym: "MtANR" RELATED [EC:1.3.1.77]
xref: EC:1.3.1.77
xref: MetaCyc:1.3.1.77-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033730
name: arogenate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arogenate + NADP+ = L-tyrosine + NADPH + CO2." [EC:1.3.1.78]
synonym: "arogenic dehydrogenase activity" BROAD [EC:1.3.1.78]
synonym: "L-arogenate:NADP+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.3.1.78]
synonym: "pretyrosine dehydrogenase activity" BROAD [EC:1.3.1.78]
synonym: "TyrAa" RELATED [EC:1.3.1.78]
synonym: "TyrAAT1" RELATED [EC:1.3.1.78]
synonym: "TyrAAT2" RELATED [EC:1.3.1.78]
xref: EC:1.3.1.78
xref: MetaCyc:RXN-5682
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033731
name: arogenate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2." [EC:1.3.1.79]
synonym: "arogenic dehydrogenase activity" BROAD [EC:1.3.1.79]
synonym: "L-arogenate:NAD(P)+ oxidoreductase (decarboxylating) activity" EXACT [EC:1.3.1.79]
synonym: "pretyrosine dehydrogenase activity" BROAD [EC:1.3.1.79]
xref: EC:1.3.1.79
xref: MetaCyc:1.3.1.78-RXN
xref: MetaCyc:1.3.1.79-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033732
name: pyrroloquinoline-quinone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-3a,4,5,6,7,8,9,9b-octahydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O." [EC:1.3.3.11]
synonym: "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing) activity" EXACT [EC:1.3.3.11]
synonym: "PqqC" RELATED [EC:1.3.3.11]
xref: EC:1.3.3.11
xref: MetaCyc:1.3.3.11-RXN
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0033734
name: (R)-benzylsuccinyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-benzylsuccinyl-CoA + 2 electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + 2 reduced electron-transferring flavoprotein." [EC:1.3.99.21]
synonym: "(R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.21]
synonym: "(R)-benzylsuccinyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.21]
synonym: "BbsG" RELATED [EC:1.3.99.21]
xref: EC:1.3.99.21
xref: UM-BBD_enzymeID:e0650
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0033735
name: aspartate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+." [EC:1.4.1.21]
synonym: "L-aspartate:NAD(P)+ oxidoreductase (deaminating) activity" EXACT [EC:1.4.1.21]
synonym: "NAD-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21]
synonym: "NADH2-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21]
synonym: "NADP+-dependent aspartate dehydrogenase activity" EXACT [EC:1.4.1.21]
xref: EC:1.4.1.21
xref: MetaCyc:1.4.1.21-RXN
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0033736
name: L-lysine 6-oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + O2 + H2O = 2-aminoadipate 6-semialdehyde + H2O2 + NH3." [EC:1.4.3.20]
synonym: "L-lysine-epsilon-oxidase activity" EXACT [EC:1.4.3.20]
synonym: "L-lysine:oxygen 6-oxidoreductase (deaminating) activity" EXACT [EC:1.4.3.20]
synonym: "Lod" RELATED [EC:1.4.3.20]
synonym: "LodA" RELATED [EC:1.4.3.20]
synonym: "marinocine" RELATED [EC:1.4.3.20]
xref: EC:1.4.3.20
xref: MetaCyc:1.4.3.20-RXN
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0033737
name: 1-pyrroline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+." [EC:1.5.1.35]
synonym: "1-pyrroline:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.35]
synonym: "ABALDH" RELATED [EC:1.5.1.35]
synonym: "gamma-aminobutyraldehyde dehydrogenase activity" EXACT [EC:1.5.1.35]
synonym: "YdcW" RELATED [EC:1.5.1.35]
xref: EC:1.5.1.35
xref: MetaCyc:1.5.1.35-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033738
name: methylenetetrahydrofolate reductase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin." [EC:1.5.7.1]
synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.7.1]
synonym: "5-methyltetrahydrofolate:ferredoxin oxidoreductase activity" EXACT [EC:1.5.7.1]
xref: EC:1.5.7.1
xref: MetaCyc:RXN-5061
is_a: GO:0033694 ! oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0033739
name: queuine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: queuine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH + 2 H+." [EC:1.7.1.13]
synonym: "7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.13]
synonym: "7-cyano-7-deazaguanine reductase activity" EXACT [EC:1.7.1.13]
synonym: "preQ0 oxidoreductase activity" EXACT [EC:1.7.1.13]
synonym: "preQ0 reductase activity" EXACT [EC:1.7.1.13]
synonym: "QueF" RELATED [EC:1.7.1.13]
synonym: "queuine:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.13]
synonym: "YkvM" RELATED [EC:1.7.1.13]
xref: EC:1.7.1.13
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor

[Term]
id: GO:0033740
name: hydroxylamine oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reactions: hydroxylamine + NH3 = hydrazine + H2O and hydrazine + acceptor = N2 + reduced acceptor." [EC:1.7.99.8]
synonym: "hydroxylamine:acceptor oxidoreductase activity" EXACT [EC:1.7.99.8]
xref: EC:1.7.99.8
xref: MetaCyc:1.7.99.8-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033741
name: adenylyl-sulfate reductase (glutathione) activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + sulfite + glutathione disulfide = adenylyl sulfate + 2 glutathione." [EC:1.8.4.9]
synonym: "5'-adenylylsulfate reductase activity" EXACT [EC:1.8.4.9]
synonym: "AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming) activity" EXACT [EC:1.8.4.9]
synonym: "AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming) activity" EXACT [EC:1.8.4.9]
synonym: "plant-type 5'-adenylylsulfate reductase activity" NARROW [EC:1.8.4.9]
xref: EC:1.8.4.9
xref: MetaCyc:1.8.4.9-RXN
is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0033743
name: peptide-methionine (R)-S-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin." [EC:1.8.4.12]
synonym: "methionine S-oxide reductase (R-form oxidizing) activity" EXACT [EC:1.8.4.12]
synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.12]
synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.12]
synonym: "methionine sulfoxide reductase B activity" NARROW [EC:1.8.4.12]
synonym: "MsrB" RELATED [EC:1.8.4.12]
synonym: "peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming] activity" EXACT [EC:1.8.4.12]
synonym: "PilB" RELATED [EC:1.8.4.12]
synonym: "pMRsr" RELATED [EC:1.8.4.12]
synonym: "pMSR" RELATED [EC:1.8.4.12]
synonym: "selenoprotein R" RELATED [EC:1.8.4.12]
synonym: "SelR" RELATED [EC:1.8.4.12]
synonym: "SelX" RELATED [EC:1.8.4.12]
xref: EC:1.8.4.12
xref: MetaCyc:1.8.4.12-RXN
is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0033744
name: L-methionine-(S)-S-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin." [EC:1.8.4.13]
synonym: "acetylmethionine sulfoxide reductase activity" EXACT [EC:1.8.4.13]
synonym: "free-methionine (S)-S-oxide reductase activity" EXACT [EC:1.8.4.13]
synonym: "fSMsr" RELATED [EC:1.8.4.13]
synonym: "L-methionine:oxidized-thioredoxin S-oxidoreductase activity" EXACT [EC:1.8.4.13]
synonym: "L-methionine:thioredoxin-disulfide S-oxidoreductase activity" EXACT [EC:1.8.4.13]
synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.13]
synonym: "methyl sulfoxide reductase I and II activity" EXACT [EC:1.8.4.13]
xref: EC:1.8.4.13
xref: MetaCyc:1.8.4.13-RXN
is_a: GO:0000317 ! methionine-S-oxide reductase activity

[Term]
id: GO:0033745
name: L-methionine-(R)-S-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin." [EC:1.8.4.14]
synonym: "free met-R-(o) reductase activity" EXACT [EC:1.8.4.14]
synonym: "free-methionine (R)-S-oxide reductase activity" EXACT [EC:1.8.4.14]
synonym: "fRMsr" RELATED [EC:1.8.4.14]
synonym: "FRMsr" RELATED [EC:1.8.4.14]
synonym: "L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming] activity" EXACT [EC:1.8.4.14]
xref: EC:1.8.4.14
xref: MetaCyc:1.8.4.14-RXN
is_a: GO:0000317 ! methionine-S-oxide reductase activity

[Term]
id: GO:0033746
name: histone demethylase activity (H3-R2 specific)
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from arginine at position 2 of the histone H3 protein." [GOC:mah]
is_a: GO:0032452 ! histone demethylase activity

[Term]
id: GO:0033747
name: versatile peroxidase activity
namespace: molecular_function
def: "Catalysis of the reactions: Reactive Black 5 + H2O2 = oxidized Reactive Black 5 + 2 H2O and donor + H2O2 = oxidized donor + 2 H2O." [EC:1.11.1.16]
synonym: "hybrid peroxidase activity" EXACT [EC:1.11.1.16]
synonym: "polyvalent peroxidase activity" EXACT [EC:1.11.1.16]
synonym: "reactive-black-5:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.16]
synonym: "VP" RELATED [EC:1.11.1.16]
xref: EC:1.11.1.16
xref: MetaCyc:RXN-8666
xref: MetaCyc:RXN-8667
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0033748
name: hydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: H2 + A = AH2." [EC:1.12.99.6]
synonym: "H2 producing hydrogenase activity" BROAD [EC:1.12.99.6]
synonym: "hydrogen-lyase activity" BROAD [EC:1.12.99.6]
synonym: "hydrogen:(acceptor) oxidoreductase activity" EXACT [EC:1.12.99.6]
synonym: "hydrogen:acceptor oxidoreductase activity" EXACT [EC:1.12.99.6]
synonym: "hydrogenlyase activity" BROAD [EC:1.12.99.6]
synonym: "uptake hydrogenase activity" BROAD [EC:1.12.99.6]
xref: EC:1.12.99.6
xref: MetaCyc:RXN0-4141
xref: MetaCyc:RXN0-5256
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0033749
name: histone demethylase activity (H4-R3 specific)
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from arginine at position 3 of the histone H4 protein." [GOC:mah]
is_a: GO:0032452 ! histone demethylase activity

[Term]
id: GO:0033750
name: ribosome localization
namespace: biological_process
def: "A process by which a ribosome is transported to, and/or maintained in, a specific location." [GOC:mah]
synonym: "ribosome localisation" EXACT []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0033751
name: linoleate diol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleate + O2 = (9Z,12Z)-(7S,8S)-dihydroxyoctadeca-9,12-dienoate." [EC:1.13.11.44]
synonym: "linoleate (8R)-dioxygenase activity" EXACT [EC:1.13.11.44]
synonym: "linoleate 8-dioxygenase activity" EXACT [EC:1.13.11.44]
synonym: "linoleate:oxygen 7S,8S-oxidoreductase activity" EXACT [EC:1.13.11.44]
xref: EC:1.13.11.44
xref: MetaCyc:1.13.11.44-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0033752
name: acetylacetone-cleaving enzyme activity
namespace: molecular_function
def: "Catalysis of the reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal." [EC:1.13.11.50]
synonym: "acetylacetone dioxygenase activity" EXACT [EC:1.13.11.50]
synonym: "acetylacetone-cleaving enzyme" RELATED [EC:1.13.11.50]
synonym: "acetylacetone:oxygen oxidoreductase activity" EXACT [EC:1.13.11.50]
synonym: "diketone cleaving dioxygenase activity" EXACT [EC:1.13.11.50]
synonym: "diketone cleaving enzyme" RELATED [EC:1.13.11.50]
synonym: "Dke1" RELATED [EC:1.13.11.50]
xref: EC:1.13.11.50
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0033753
name: establishment of ribosome localization
namespace: biological_process
def: "The directed movement of the ribosome to a specific location." [GOC:mah]
synonym: "establishment of ribosome localisation" EXACT []
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization
relationship: part_of GO:0033750 ! ribosome localization

[Term]
id: GO:0033754
name: indoleamine 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine; includes both reactions D-tryptophan + O2 = N-formyl-D-kynurenine and L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.52]
synonym: "D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity" NARROW [EC:1.13.11.52]
synonym: "IDO" RELATED [EC:1.13.11.52]
synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.52]
xref: EC:1.13.11.52
xref: MetaCyc:RXN-8664
xref: MetaCyc:RXN-8665
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0033755
name: sulfur oxygenase/reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+." [EC:1.13.11.55]
synonym: "SOR" RELATED [EC:1.13.11.55]
synonym: "sulfur oxygenase activity" BROAD [EC:1.13.11.55]
synonym: "sulfur:oxygen oxidoreductase (hydrogen-sulfide- and sulfite-forming) activity" EXACT [EC:1.13.11.55]
synonym: "sulphur oxygenase/reductase activity" EXACT []
xref: EC:1.13.11.55
xref: MetaCyc:1.13.11.55-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0033756
name: Oplophorus-luciferin 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: Oplophorus luciferin + O2 = oxidized Oplophorus luciferin + CO2 + hnu." [EC:1.13.12.13]
synonym: "Oplophorus luciferase activity" EXACT [EC:1.13.12.13]
synonym: "Oplophorus-luciferin:oxygen 2-oxidoreductase (decarboxylating) activity" EXACT [EC:1.13.12.13]
xref: EC:1.13.12.13
xref: MetaCyc:RXN-3361
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0033757
name: glucoside 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor." [EC:1.1.99.13]
synonym: "D-aldohexopyranoside dehydrogenase" EXACT [EC:1.1.99.13]
synonym: "D-aldohexoside:(acceptor) 3-oxidoreductase" EXACT [EC:1.1.99.13]
synonym: "D-aldohexoside:acceptor 3-oxidoreductase" EXACT [EC:1.1.99.13]
synonym: "D-aldohexoside:cytochrome c oxidoreductase" EXACT [EC:1.1.99.13]
synonym: "hexopyranoside-cytochrome c oxidoreductase" EXACT [EC:1.1.99.13]
xref: EC:1.1.99.13
xref: MetaCyc:GLUCOSIDE-3-DEHYDROGENASE-RXN
xref: Wikipedia:Glucoside_3-dehydrogenase
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0033758
name: clavaminate synthase activity
namespace: molecular_function
def: "Catalysis of the reactions: deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 + H2O and proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + 2 H2O and dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + 2 H2O." [EC:1.14.11.21]
synonym: "clavaminate synthase 2 activity" NARROW [EC:1.14.11.21]
synonym: "clavaminic acid synthase activity" EXACT [EC:1.14.11.21]
synonym: "deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.21]
xref: EC:1.14.11.21
xref: MetaCyc:1.14.11.21-RXN
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0033759
name: flavone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O." [EC:1.14.11.22]
synonym: "flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating) activity" EXACT [EC:1.14.11.22]
synonym: "flavone synthase I activity" EXACT [EC:1.14.11.22]
synonym: "FNS I" RELATED [EC:1.14.11.22]
xref: EC:1.14.11.22
xref: MetaCyc:RXN-8000
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0033760
name: 2'-deoxymugineic-acid 2'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-deoxymugineic acid + 2-oxoglutarate + O2 = mugineic acid + succinate + CO2." [EC:1.14.11.24]
synonym: "2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) activity" EXACT [EC:1.14.11.24]
synonym: "IDS3" RELATED [EC:1.14.11.24]
xref: EC:1.14.11.24
xref: MetaCyc:1.14.11.24-RXN
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0033761
name: mugineic-acid 3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reactions: mugineic acid + 2-oxoglutarate + O2 = 3-epihydroxymugineic acid + succinate + CO2 and 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2." [EC:1.14.11.25]
synonym: "IDS2" RELATED [EC:1.14.11.25]
synonym: "mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.25]
xref: EC:1.14.11.25
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0033762
name: response to glucagon stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:sl]
is_a: GO:0043434 ! response to peptide hormone stimulus

[Term]
id: GO:0033763
name: proline 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.28]
synonym: "L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.28]
synonym: "P-3-H" RELATED [EC:1.14.11.28]
xref: EC:1.14.11.28
xref: MetaCyc:1.14.11.28-RXN
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0033764
name: steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative." [GOC:mah]
subset: gosubset_prok
xref: EC:1.1.1.-
is_a: GO:0016229 ! steroid dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033765
name: steroid dehydrogenase activity, acting on the CH-CH group of donors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative." [GOC:mah]
subset: gosubset_prok
xref: EC:1.1.1.-
is_a: GO:0016229 ! steroid dehydrogenase activity
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0033766
name: 2-hydroxyquinoline 8-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = quinolin-2,8-diol + NAD+ + H2O." [EC:1.14.13.61]
synonym: "2-oxo-1,2-dihydroquinoline 8-monooxygenase activity" EXACT [EC:1.14.13.61]
synonym: "quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating) activity" EXACT [EC:1.14.13.61]
xref: EC:1.14.13.61
xref: MetaCyc:1.14.13.61-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033767
name: 4-hydroxyacetophenone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4-hydroxyphenyl)ethan-1-one + NADPH + H+ + O2 = 4-hydroxyphenyl acetate + NADP+ + H2O." [EC:1.14.13.80, EC:1.14.13.84]
synonym: "(+)-limonene 6-monooxygenase activity" EXACT [EC:1.14.13.80]
synonym: "(+)-limonene-6-hydroxylase activity" EXACT [EC:1.14.13.80]
synonym: "(4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) activity" EXACT [EC:1.14.13.84]
synonym: "(R)-limonene 6-monooxygenase activity" EXACT [EC:1.14.13.80]
synonym: "(R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" EXACT [EC:1.14.13.80]
synonym: "HAPMO" RELATED [EC:1.14.13.84]
xref: EC:1.14.13.80
xref: EC:1.14.13.84
xref: MetaCyc:1.14.13.84-RXN
xref: UM-BBD_enzymeID:e0479
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033768
name: SUMO-targeted ubiquitin ligase complex
namespace: cellular_component
def: "A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes." [GOC:vw, PMID:17762864, PMID:17762865]
is_a: GO:0000152 ! nuclear ubiquitin ligase complex

[Term]
id: GO:0033769
name: glyceollin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin + NADP+ + 2 H2O." [EC:1.14.13.85]
synonym: "2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan,NADPH:oxygen oxidoreductase (cyclizing) activity" EXACT [EC:1.14.13.85]
synonym: "dimethylallyl-3,6a,9-trihydroxypterocarpan cyclase activity" EXACT [EC:1.14.13.85]
xref: EC:1.14.13.85
xref: MetaCyc:2.5.1.36-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033770
name: 2-hydroxyisoflavanone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: apigenin + 2 NADPH + 2 H+ + O2 = 2-hydroxy-2,3-dihydrogenistein + 2 NADP+ + H2O." [EC:1.14.13.86]
synonym: "2-HIS" RELATED [EC:1.14.13.86]
synonym: "apigenin,NADPH:oxygen oxidoreductase (isoflavanone-forming) activity" EXACT [EC:1.14.13.86]
xref: EC:1.14.13.86
xref: MetaCyc:RXN-7750
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033771
name: licodione synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: liquiritigenin + NADPH + H+ + O2 = licodione + NADP+ + H2O." [EC:1.14.13.87]
synonym: "(2S)-flavanone 2-hydroxylase activity" EXACT [EC:1.14.13.87]
synonym: "liquiritigenin,NADPH:oxygen oxidoreductase (licodione-forming) activity" EXACT [EC:1.14.13.87]
xref: EC:1.14.13.87
xref: MetaCyc:1.14.13.87-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033772
name: flavonoid 3',5'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reactions: a flavanone + NADPH + H+ + O2 = a 3'-hydroxyflavanone + NADP+ + H2O and a 3'-hydroxyflavanone + NADPH + H+ + O2 = a 3',5'-dihydroxyflavanone + NADP+ + H2O." [EC:1.14.13.88]
synonym: "F3',5'H" RELATED [EC:1.14.13.88]
synonym: "F3'5'H" RELATED [EC:1.14.13.88]
synonym: "flavanone,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.88]
xref: EC:1.14.13.88
xref: MetaCyc:RXN-7783
xref: MetaCyc:RXN-8671
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033773
name: isoflavone 2'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: an isoflavone + NADPH + H+ + O2 = a 2'-hydroxyisoflavone + NADP+ + H2O." [EC:1.14.13.89]
synonym: "CYP Ge-3" RELATED [EC:1.14.13.89]
synonym: "CYP81E1" RELATED [EC:1.14.13.89]
synonym: "isoflavone 2'-monooxygenase activity" BROAD [EC:1.14.13.89]
synonym: "isoflavone,NADPH:oxygen oxidoreductase (2'-hydroxylating) activity" EXACT [EC:1.14.13.89]
xref: EC:1.14.13.89
xref: MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033774
name: basal labyrinth
namespace: cellular_component
def: "A region in the lower half of some cells formed from extensive infoldings of the basal plasma membrane; includes cytoplasm adjacent to the infolded membrane." [GOC:mah, GOC:sart, PMID:11640882]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0045178 ! basal part of cell

[Term]
id: GO:0033775
name: deoxysarpagine hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-deoxysarpagine + NADPH + H+ + O2 = sarpagine + NADP+ + H2O." [EC:1.14.13.91]
synonym: "10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating) activity" EXACT [EC:1.14.13.91]
synonym: "DOSH" RELATED [EC:1.14.13.91]
xref: EC:1.14.13.91
xref: MetaCyc:1.14.13.91-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033776
name: phenylacetone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylacetone + NADPH + H+ + O2 = benzyl acetate + NADP+ + H2O." [EC:1.14.13.92]
synonym: "PAMO" RELATED [EC:1.14.13.92]
synonym: "phenylacetone,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.92]
xref: EC:1.14.13.92
xref: MetaCyc:1.14.13.92-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033777
name: lithocholate 6beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: lithocholate + NADPH + H+ + O2 = 6beta-hydroxylithocholate + NADP+ + H2O." [EC:1.14.13.94]
synonym: "6beta-hydroxylase activity" BROAD [EC:1.14.13.94]
synonym: "CYP3A10" RELATED [EC:1.14.13.94]
synonym: "cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase activity" EXACT [EC:1.14.13.94]
synonym: "lithocholate 6beta-monooxygenase activity" EXACT [EC:1.14.13.94]
synonym: "lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating) activity" EXACT [EC:1.14.13.94]
xref: EC:1.14.13.94
xref: MetaCyc:1.14.13.94-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033778
name: 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + NADPH + H+ + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + NADP+ + H2O." [EC:1.14.13.95]
synonym: "7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase activity" EXACT [EC:1.14.13.95]
synonym: "7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity" EXACT [EC:1.14.13.95]
synonym: "CYP12" RELATED [EC:1.14.13.95]
synonym: "HCO 12alpha-hydroxylase activity" EXACT [EC:1.14.13.95]
synonym: "sterol 12alpha-hydroxylase activity" BROAD [EC:1.14.13.95]
xref: EC:1.14.13.95
xref: MetaCyc:1.14.13.95-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033779
name: 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + NADPH + H+ + O2 = 5beta-cholestane-3alpha,7alpha,12alpha-triol + NADP+ + H2O." [EC:1.14.13.96]
synonym: "5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase activity" EXACT [EC:1.14.13.96]
synonym: "5beta-cholestane-3alpha,7alpha-diol,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity" EXACT [EC:1.14.13.96]
synonym: "CYP8B1" RELATED [EC:1.14.13.96]
synonym: "cytochrome P450 8B1" RELATED [EC:1.14.13.96]
synonym: "sterol 12alpha-hydroxylase activity" BROAD [EC:1.14.13.96]
xref: EC:1.14.13.96
xref: MetaCyc:1.14.13.96-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033780
name: taurochenodeoxycholate 6alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O." [EC:1.14.13.97]
synonym: "CYP3A4" RELATED [EC:1.14.13.97]
synonym: "CYP4A21" RELATED [EC:1.14.13.97]
synonym: "taurochenodeoxycholate 6alpha-monooxygenase activity" EXACT [EC:1.14.13.97]
synonym: "taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity" EXACT [EC:1.14.13.97]
xref: EC:1.14.13.97
xref: MetaCyc:RXN-7977
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033781
name: cholesterol 24-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = (24S)-24-hydroxycholesterol + NADP+ + H2O." [EC:1.14.13.98]
synonym: "cholesterol 24-monooxygenase activity" EXACT [EC:1.14.13.98]
synonym: "cholesterol 24S-hydroxylase activity" EXACT [EC:1.14.13.98]
synonym: "cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity" EXACT [EC:1.14.13.98]
synonym: "CYP46" RELATED [EC:1.14.13.98]
synonym: "CYP46A1" RELATED [EC:1.14.13.98]
synonym: "cytochrome P450 46A1" RELATED [EC:1.14.13.98]
xref: EC:1.14.13.98
xref: MetaCyc:1.14.13.98-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033782
name: 24-hydroxycholesterol 7alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (24R)-cholest-5-ene-3beta,24-diol + NADPH + H+ + O2 = (24R)-cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O." [EC:1.14.13.99]
synonym: "(24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" EXACT [EC:1.14.13.99]
synonym: "24-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.99]
synonym: "CYP39A1" RELATED [EC:1.14.13.99]
synonym: "CYP39A1 oxysterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.99]
xref: EC:1.14.13.99
xref: MetaCyc:1.14.13.99-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033783
name: 25-hydroxycholesterol 7alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O and cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O." [EC:1.14.13.100]
synonym: "25-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.100]
synonym: "cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" EXACT [EC:1.14.13.100]
synonym: "CYP7B1" RELATED [EC:1.14.13.100]
synonym: "CYP7B1 oxysterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.100]
xref: EC:1.14.13.100
xref: MetaCyc:RXN-7980
xref: MetaCyc:RXN-7981
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033784
name: senecionine N-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: senecionine + NADPH + H+ + O2 = senecionine N-oxide + NADP+ + H2O." [EC:1.14.13.101]
synonym: "senecionine monooxygenase (N-oxide-forming) activity" EXACT [EC:1.14.13.101]
synonym: "senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming) activity" EXACT [EC:1.14.13.101]
synonym: "SNO" RELATED [EC:1.14.13.101]
xref: EC:1.14.13.101
xref: MetaCyc:1.14.13.101-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0033785
name: heptose 7-phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP." [MetaCyc:RXN0-4341]
subset: gosubset_prok
synonym: "D-alpha,beta-D-heptose 7-phosphate 1-kinase activity" EXACT []
xref: EC:2.7.1.-
xref: IMG:02784
xref: MetaCyc:RXN0-4341
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0033786
name: heptose 1-phosphate adenyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose." [MetaCyc:RXN0-4342]
subset: gosubset_prok
synonym: "D-beta-D-heptose 1-phosphate adenylyltransferase activity" EXACT []
xref: IMG:02786
xref: MetaCyc:RXN0-4342
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0033787
name: cyanocobalamin reductase (cyanide-eliminating) activity
namespace: molecular_function
def: "Catalysis of the reaction: cob(I)alamin + cyanide + NADP+ = cyanocob(III)alamin + NADPH + H+." [EC:1.16.1.6]
synonym: "cob(I)alamin, cyanide:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.6]
synonym: "cyanocobalamin reductase (NADPH, cyanide-eliminating) activity" EXACT [EC:1.16.1.6]
synonym: "cyanocobalamin reductase (NADPH; CN-eliminating) activity" EXACT [EC:1.16.1.6]
synonym: "cyanocobalamin reductase activity" EXACT [EC:1.16.1.6]
synonym: "NADPH2:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity" EXACT [EC:1.16.1.6]
synonym: "NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity" EXACT [EC:1.16.1.6]
xref: EC:1.16.1.6
xref: MetaCyc:1.6.99.12-RXN
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0033788
name: leucoanthocyanidin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+." [EC:1.17.1.3]
synonym: "(2R,3S)-catechin:NADP+ 4-oxidoreductase activity" EXACT [EC:1.17.1.3]
synonym: "leucocyanidin reductase activity" EXACT [EC:1.17.1.3]
xref: EC:1.17.1.3
xref: MetaCyc:RXN-1484
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0033789
name: phenylacetyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylacetyl-CoA + H2O + 2 quinone = phenylglyoxylyl-CoA + 2 quinol." [EC:1.17.5.1]
synonym: "phenylacetyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.17.5.1]
synonym: "phenylacetyl-CoA:quinone oxidoreductase activity" EXACT [EC:1.17.5.1]
xref: EC:1.17.5.1
xref: MetaCyc:1.17.5.1-RXN
is_a: GO:0033695 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor

[Term]
id: GO:0033790
name: hydroxymethylfurfural reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NAD(P)H + H+ = 2,5-bis-hydroxymethylfuran + NAD(P)+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391]
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0033791
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor." [EC:1.17.99.3]
synonym: "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating) activity" EXACT [EC:1.17.99.3]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase activity" EXACT [EC:1.17.99.3]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase activity" EXACT [EC:1.17.99.3]
synonym: "THC-CoA oxidase activity" EXACT [EC:1.17.99.3]
synonym: "THCA-CoA oxidase activity" EXACT [EC:1.17.99.3]
synonym: "trihydroxycoprostanoyl-CoA oxidase activity" EXACT [EC:1.17.99.3]
xref: EC:1.17.99.3
xref: MetaCyc:1.17.99.3-RXN
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0033792
name: bile-acid 7alpha-dehydroxylase activity
namespace: molecular_function
def: "Catalysis of the reactions: deoxycholate + FAD + H2O = cholate + FADH2 and lithocholate + FAD + H2O = chenodeoxycholate + FADH2." [EC:1.17.99.5]
synonym: "7alpha-dehydroxylase activity" EXACT [EC:1.17.99.5]
synonym: "bile acid 7-dehydroxylase activity" EXACT [EC:1.17.99.5]
synonym: "cholate 7alpha-dehydroxylase activity" EXACT [EC:1.17.99.5]
synonym: "deoxycholate:FAD oxidoreductase (7alpha-dehydroxylating) activity" EXACT [EC:1.17.99.5]
synonym: "deoxycholate:NAD+ oxidoreductase activity" EXACT [EC:1.17.99.5]
xref: EC:1.17.99.5
xref: MetaCyc:RXN-8658
xref: MetaCyc:RXN-8659
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0033793
name: aureusidin synthase activity
namespace: molecular_function
def: "Catalysis of the reactions: 2',4,4',6'-tetrahydroxychalcone + O2 = aureusidin + H2O and 2',3,4,4',6'-pentahydroxychalcone + 1/2 O2 = aureusidin + H2O." [EC:1.21.3.6]
synonym: "2',4,4',6'-tetrahydroxychalcone:oxygen oxidoreductase activity" EXACT [EC:1.21.3.6]
xref: EC:1.21.3.6
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0033794
name: sarcosine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin." [EC:1.21.4.3]
synonym: "acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase (N-methylglycine-forming) activity" EXACT [EC:1.21.4.3]
xref: EC:1.21.4.3
is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor

[Term]
id: GO:0033795
name: betaine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl phosphate + trimethylamine + thioredoxin disulfide = N,N,N-trimethylglycine + phosphate + thioredoxin." [EC:1.21.4.4]
synonym: "acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (N,N,N-trimethylglycine-forming) activity" EXACT [EC:1.21.4.4]
xref: EC:1.21.4.4
is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor

[Term]
id: GO:0033796
name: sulfur reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduction of elemental sulfur or polysulfide to hydrogen sulfide." [EC:1.97.1.3]
synonym: "(donor):sulfur oxidoreductase activity" EXACT [EC:1.97.1.3]
synonym: "sulphur reductase activity" EXACT []
xref: EC:1.97.1.3
xref: MetaCyc:1.97.1.3-RXN
xref: MetaCyc:RXN-8269
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0033797
name: selenate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: selenite + H2O + acceptor = selenate + reduced acceptor." [EC:1.97.1.9]
synonym: "selenite:reduced acceptor oxidoreductase activity" EXACT [EC:1.97.1.9]
xref: EC:1.97.1.9
xref: MetaCyc:RXN0-2101
xref: UM-BBD_enzymeID:e0508
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0033798
name: thyroxine 5-deiodinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2." [EC:1.97.1.11]
synonym: "acceptor:3,3',5'-triiodo-L-thyronine oxidoreductase (iodinating) activity" EXACT [EC:1.97.1.11]
synonym: "diiodothyronine 5'-deiodinase activity" BROAD [EC:1.97.1.11]
synonym: "iodothyronine 5-deiodinase activity" EXACT [EC:1.97.1.11]
synonym: "iodothyronine inner ring monodeiodinase activity" EXACT [EC:1.97.1.11]
synonym: "type III iodothyronine deiodinase activity" NARROW [EC:1.97.1.11]
xref: EC:1.97.1.11
xref: MetaCyc:1.97.1.11-RXN
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0033799
name: myricetin 3'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + myricetin = S-adenosyl-L-homocysteine + laricitrin." [MetaCyc:RXN-8451]
comment: Note that this term represents one of two reactions that are grouped together in EC 2.1.1.149.
synonym: "CrCOMT2" RELATED [EC:2.1.1.149]
synonym: "flavonoid 3',5'-O-dimethyltransferase activity" RELATED [EC:2.1.1.149]
synonym: "S-adenosyl-L-methionine:myricetin O-methyltransferase activity" RELATED [EC:2.1.1.149]
xref: EC:2.1.1.149
xref: MetaCyc:RXN-8451
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033800
name: isoflavone 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 7-methoxyisoflavone." [EC:2.1.1.150]
synonym: "S-adenosyl-L-methionine:hydroxyisoflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.150]
xref: EC:2.1.1.150
xref: MetaCyc:RXN-6241
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033801
name: vitexin 2''-O-rhamnoside 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside." [EC:2.1.1.153]
synonym: "S-adenosyl-L-methionine:vitexin-2''-O-beta-L-rhamnoside 7-O-methyltransferase activity" EXACT [EC:2.1.1.153]
xref: EC:2.1.1.153
xref: MetaCyc:RXN-4981
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033802
name: isoliquiritigenin 2'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoliquiritigenin = S-adenosyl-L-homocysteine + 2'-O-methylisoliquiritigenin." [EC:2.1.1.154]
synonym: "chalcone OMT" RELATED [EC:2.1.1.154]
synonym: "CHMT" RELATED [EC:2.1.1.154]
synonym: "S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase activity" EXACT [EC:2.1.1.154]
xref: EC:2.1.1.154
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033803
name: kaempferol 4'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + kaempferide." [EC:2.1.1.155]
synonym: "F 4'-OMT" RELATED [EC:2.1.1.155]
synonym: "S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase activity" EXACT [EC:2.1.1.155]
synonym: "S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase activity" EXACT [EC:2.1.1.155]
xref: EC:2.1.1.155
xref: MetaCyc:2.1.1.155-RXN
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033804
name: glycine/sarcosine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reactions: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine and S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine." [EC:2.1.1.156]
synonym: "ApGSMT" RELATED [EC:2.1.1.156]
synonym: "glycine sarcosine N-methyltransferase activity" EXACT [EC:2.1.1.156]
synonym: "glycine-sarcosine methyltransferase activity" EXACT [EC:2.1.1.156]
synonym: "GMT" RELATED [EC:2.1.1.156]
synonym: "GSMT" RELATED [EC:2.1.1.156]
synonym: "S-adenosyl-L-methionine:sarcosine N-methyltransferase activity" EXACT [EC:2.1.1.156]
xref: EC:2.1.1.156
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033805
name: sarcosine/dimethylglycine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reactions: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine and S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine." [EC:2.1.1.157]
synonym: "ApDMT" RELATED [EC:2.1.1.157]
synonym: "S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity" EXACT [EC:2.1.1.157]
synonym: "sarcosine dimethylglycine N-methyltransferase activity" EXACT [EC:2.1.1.157]
synonym: "sarcosine-dimethylglycine methyltransferase activity" EXACT [EC:2.1.1.157]
synonym: "SDMT" RELATED [EC:2.1.1.157]
xref: EC:2.1.1.157
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0033806
name: fluorothreonine transaldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine." [EC:2.2.1.8]
synonym: "fluoroacetaldehyde:L-threonine aldehydetransferase activity" EXACT [EC:2.2.1.8]
xref: EC:2.2.1.8
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0033807
name: icosanoyl-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H+ = icosanoyl-CoA + CO2 + 2 NAD(P)+." [EC:2.3.1.119]
synonym: "acyl-CoA elongase activity" EXACT [EC:2.3.1.119]
synonym: "C18-CoA elongase activity" EXACT [EC:2.3.1.119]
synonym: "stearoyl-CoA elongase activity" EXACT [EC:2.3.1.119]
synonym: "stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing) activity" EXACT [EC:2.3.1.119]
xref: EC:2.3.1.119
xref: MetaCyc:ICOSANOYL-COA-SYNTHASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033808
name: 6'-deoxychalcone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O." [EC:2.3.1.170]
synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing) activity" EXACT [EC:2.3.1.170]
xref: EC:2.3.1.170
xref: MetaCyc:RXN-3142
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033809
name: anthocyanin 6''-O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside)." [EC:2.3.1.171]
synonym: "3MaT" RELATED [EC:2.3.1.171]
synonym: "Dv3MaT" RELATED [EC:2.3.1.171]
synonym: "malonyl-CoA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.171]
synonym: "malonyl-coenzymeA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.171]
xref: EC:2.3.1.171
xref: MetaCyc:2.3.1.171-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033810
name: anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonyl-CoA + pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside = CoA + 4'''-demalonylsalvianin." [EC:2.3.1.172]
synonym: "malonyl-CoA:pelargonidin-3-O-(6-caffeoyl-beta-D-glucoside)-5-O-beta-D-glucoside 6'''-O-malonyltransferase activity" EXACT [EC:2.3.1.172]
synonym: "Ss5MaT1" RELATED [EC:2.3.1.172]
xref: EC:2.3.1.172
xref: MetaCyc:2.3.1.172-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033811
name: flavonol-3-O-triglucoside O-coumaroyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]." [EC:2.3.1.173]
synonym: "4-coumaroyl-CoA:flavonol-3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 6'''-O-4-coumaroyltransferase activity" EXACT [EC:2.3.1.173]
xref: EC:2.3.1.173
xref: MetaCyc:2.3.1.173-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033812
name: 3-oxoadipyl-CoA thiolase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA." [EC:2.3.1.174]
synonym: "succinyl-CoA:acetyl-CoA C-succinyltransferase activity" EXACT [EC:2.3.1.174]
xref: EC:2.3.1.174
xref: MetaCyc:RXN-3641
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033813
name: deacetylcephalosporin-C acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + deacetylcephalosporin C = CoA + cephalosporin C." [EC:2.3.1.175]
synonym: "acetyl coenzyme A:DAC acetyltransferase activity" EXACT [EC:2.3.1.175]
synonym: "acetyl-CoA:DAC acetyltransferase activity" EXACT [EC:2.3.1.175]
synonym: "acetyl-CoA:DAC O-acetyltransferase activity" EXACT [EC:2.3.1.175]
synonym: "acetyl-CoA:deacetylcephalosporin-C acetyltransferase activity" EXACT [EC:2.3.1.175]
synonym: "acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase activity" EXACT [EC:2.3.1.175]
synonym: "cefG" RELATED [EC:2.3.1.175]
synonym: "CPC acetylhydrolase activity" EXACT [EC:2.3.1.175]
synonym: "DAC acetyltransferase activity" EXACT [EC:2.3.1.175]
synonym: "DAC-AT" RELATED [EC:2.3.1.175]
synonym: "deacetylcephalosporin C acetyltransferase activity" EXACT [EC:2.3.1.175]
xref: EC:2.3.1.175
xref: MetaCyc:2.3.1.175-RXN
is_a: GO:0016408 ! C-acyltransferase activity

[Term]
id: GO:0033814
name: propanoyl-CoA C-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA." [EC:2.3.1.176]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.176]
synonym: "peroxisomal thiolase 2 activity" NARROW [EC:2.3.1.176]
synonym: "PTE-2" RELATED [EC:2.3.1.176]
synonym: "SCP-X" RELATED [EC:2.3.1.176]
synonym: "SCPchi" RELATED [EC:2.3.1.176]
synonym: "sterol carrier protein-chi" RELATED [EC:2.3.1.176]
synonym: "sterol carrier protein-X" RELATED [EC:2.3.1.176]
xref: EC:2.3.1.176
xref: MetaCyc:2.3.1.176-RXN
is_a: GO:0016408 ! C-acyltransferase activity

[Term]
id: GO:0033815
name: biphenyl synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2." [EC:2.3.1.177]
synonym: "BIS" RELATED [EC:2.3.1.177]
synonym: "malonyl-CoA:benzoyl-CoA malonyltransferase activity" EXACT [EC:2.3.1.177]
xref: EC:2.3.1.177
xref: MetaCyc:2.3.1.177-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033816
name: diaminobutyrate acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + L-2,4-diaminobutanoate = CoA + N4-acetyl-L-2,4-diaminobutanoate." [EC:2.3.1.178]
synonym: "2,4-diaminobutanoate acetyltransferase activity" EXACT [EC:2.3.1.178]
synonym: "acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase activity" EXACT [EC:2.3.1.178]
synonym: "acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase activity" EXACT [EC:2.3.1.178]
synonym: "DAB acetyltransferase activity" EXACT [EC:2.3.1.178]
synonym: "DABA acetyltransferase activity" EXACT [EC:2.3.1.178]
synonym: "DABAcT" RELATED [EC:2.3.1.178]
synonym: "diaminobutyric acid acetyltransferase activity" EXACT [EC:2.3.1.178]
synonym: "EctA" RELATED [EC:2.3.1.178]
synonym: "L-2,4-diaminobutanoate acetyltransferase activity" EXACT [EC:2.3.1.178]
synonym: "L-2,4-diaminobutyrate acetyltransferase activity" EXACT [EC:2.3.1.178]
xref: EC:2.3.1.178
xref: MetaCyc:2.3.1.178-RXN
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0033817
name: beta-ketoacyl-acyl-carrier-protein synthase II activity
namespace: molecular_function
def: "Catalysis of the reaction: (Z)-hexadec-11-enoyl-acyl-carrier-protein + malonyl-acyl-carrier-protein = (Z)-3-oxooctadec-13-enoyl-acyl-carrier-protein + CO2 + acyl-carrier-protein." [EC:2.3.1.179]
synonym: "(Z)-hexadec-11-enoyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating) activity" EXACT [EC:2.3.1.179]
synonym: "3-oxoacyl-acyl carrier protein synthase I activity" EXACT [EC:2.3.1.179]
synonym: "beta-ketoacyl-ACP synthase II activity" EXACT [EC:2.3.1.179]
synonym: "FabF" RELATED [EC:2.3.1.179]
synonym: "KAS II" RELATED [EC:2.3.1.179]
synonym: "KASII" RELATED [EC:2.3.1.179]
xref: EC:2.3.1.179
xref: MetaCyc:2.3.1.179-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033818
name: beta-ketoacyl-acyl-carrier-protein synthase III activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + malonyl-acyl-carrier-protein = acetoacyl-acyl-carrier-protein + CoA + CO2." [EC:2.3.1.180]
synonym: "3-ketoacyl-acyl carrier protein synthase III activity" EXACT [EC:2.3.1.180]
synonym: "3-oxoacyl:ACP synthase III activity" EXACT [EC:2.3.1.180]
synonym: "acetyl-CoA:malonyl-acyl-carrier-protein C-acyltransferase activity" EXACT [EC:2.3.1.180]
synonym: "beta-ketoacyl (acyl carrier protein) synthase III activity" EXACT [EC:2.3.1.180]
synonym: "beta-ketoacyl-ACP synthase III activity" EXACT [EC:2.3.1.180]
synonym: "beta-ketoacyl-acyl carrier protein synthase III activity" EXACT [EC:2.3.1.180]
synonym: "FabH" RELATED [EC:2.3.1.180]
synonym: "KAS III" RELATED [EC:2.3.1.180]
synonym: "KASIII" RELATED [EC:2.3.1.180]
xref: EC:2.3.1.180
xref: MetaCyc:2.3.1.180-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033819
name: lipoyl(octanoyl) transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: octanoyl-acyl-carrier-protein + protein = protein N6-(octanoyl)lysine + acyl carrier protein." [EC:2.3.1.181]
synonym: "LipB" RELATED [EC:2.3.1.181]
synonym: "lipoate/octanoate transferase activity" EXACT [EC:2.3.1.181]
synonym: "lipoyl (octanoyl)-acyl carrier protein:protein transferase activity" EXACT [EC:2.3.1.181]
synonym: "lipoyl (octanoyl)-acyl-carrier-protein-protein N-lipoyltransferase activity" EXACT [EC:2.3.1.181]
synonym: "octanoyl-acyl carrier protein-protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181]
synonym: "octanoyl-acyl-carrier-protein-protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181]
synonym: "octanoyl-acyl-carrier-protein:protein N-octanoyltransferase activity" EXACT [EC:2.3.1.181]
xref: EC:2.3.1.181
xref: MetaCyc:2.3.1.181-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0033820
name: DNA alpha-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Transfers an alpha-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA." [EC:2.4.1.26]
synonym: "T2-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26]
synonym: "T4-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26]
synonym: "T6-HMC-alpha-glucosyl transferase activity" EXACT [EC:2.4.1.26]
synonym: "UDP-glucose:DNA alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.26]
synonym: "UDPglucose-DNA alpha-glucosyltransferase activity" EXACT [EC:2.4.1.26]
synonym: "uridine diphosphoglucose-deoxyribonucleate alpha-glucosyltransferase activity" EXACT [EC:2.4.1.26]
xref: EC:2.4.1.26
xref: MetaCyc:2.4.1.26-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033821
name: DNA beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Transfers a beta-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA." [EC:2.4.1.27]
synonym: "T4 phage beta-glucosyltransferase activity" EXACT [EC:2.4.1.27]
synonym: "T4-beta-glucosyl transferase activity" EXACT [EC:2.4.1.27]
synonym: "T4-HMC-beta-glucosyl transferase activity" EXACT [EC:2.4.1.27]
synonym: "UDP glucose-DNA beta-glucosyltransferase activity" EXACT [EC:2.4.1.27]
synonym: "UDP-glucose:DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.27]
synonym: "UDPglucose:DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.27]
synonym: "uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase activity" EXACT [EC:2.4.1.27]
xref: EC:2.4.1.27
xref: MetaCyc:2.4.1.27-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033822
name: glucosyl-DNA beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Transfers a beta-D-glucosyl residue from UDP-glucose to a glucosylhydroxymethylcytosine residue in DNA." [EC:2.4.1.28]
synonym: "T6-beta-glucosyl transferase activity" EXACT [EC:2.4.1.28]
synonym: "T6-glucosyl-HMC-beta-glucosyl transferase activity" EXACT [EC:2.4.1.28]
synonym: "UDP-glucose:D-glucosyl-DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.28]
synonym: "UDPglucose:D-glucosyl-DNA beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.28]
synonym: "uridine diphosphoglucose-glucosyldeoxyribonucleate beta-glucosyltransferase activity" EXACT [EC:2.4.1.28]
xref: EC:2.4.1.28
xref: MetaCyc:2.4.1.28-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033823
name: procollagen glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen." [EC:2.4.1.66]
synonym: "collagen glucosyltransferase activity" EXACT [EC:2.4.1.66]
synonym: "collagen hydroxylysyl glucosyltransferase activity" EXACT [EC:2.4.1.66]
synonym: "galactosylhydroxylysine glucosyltransferase activity" EXACT [EC:2.4.1.66]
synonym: "galactosylhydroxylysine-glucosyltransferase activity" EXACT [EC:2.4.1.66]
synonym: "galactosylhydroxylysyl glucosyltransferase activity" EXACT [EC:2.4.1.66]
synonym: "UDP-glucose-collagenglucosyltransferase activity" EXACT [EC:2.4.1.66]
synonym: "UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity" EXACT [EC:2.4.1.66]
synonym: "UDPglucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity" EXACT [EC:2.4.1.66]
synonym: "uridine diphosphoglucose-collagen glucosyltransferase activity" EXACT [EC:2.4.1.66]
xref: EC:2.4.1.66
xref: MetaCyc:PROCOLLAGEN-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033824
name: alternansucrase activity
namespace: molecular_function
def: "Catalysis of the reaction: Transfers alternately an alpha-D-glucosyl residue from sucrose to the 6-position and the 3-position of the non-reducing terminal residue of an alpha-D-glucan, thus producing a glucan having alternating alpha-1,6- and alpha-1,3-linkages." [EC:2.4.1.140]
synonym: "sucrose-1,6(3)-alpha-glucan 6(3)-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.140]
synonym: "sucrose:1,6(1,3)-alpha-D-glucan 6(3)-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.140]
synonym: "sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase activity" BROAD [EC:2.4.1.140]
xref: EC:2.4.1.140
xref: MetaCyc:2.4.1.140-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033825
name: oligosaccharide 4-alpha-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Transfers the non-reducing terminal alpha-D-glucose residue from a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan, thus bringing about the hydrolysis of oligosaccharides." [EC:2.4.1.161]
synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.161]
synonym: "1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.161]
synonym: "amylase III activity" EXACT [EC:2.4.1.161]
xref: EC:2.4.1.161
xref: MetaCyc:2.4.1.161-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033826
name: xyloglucan 4-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Transfers a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-1,4-D-glucosyl-D-glucose linkage." [EC:2.4.1.168]
synonym: "UDP-glucose:xyloglucan 1,4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168]
synonym: "UDPglucose:xyloglucan 1,4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168]
synonym: "uridine diphosphoglucose-xyloglucan 4beta-glucosyltransferase activity" EXACT [EC:2.4.1.168]
synonym: "xyloglucan 4beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.168]
synonym: "xyloglucan glucosyltransferase activity" EXACT [EC:2.4.1.168]
xref: EC:2.4.1.168
xref: MetaCyc:2.4.1.168-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033827
name: high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Transfers an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-1,6 to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum." [EC:2.4.1.197]
synonym: "acetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197]
synonym: "UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197]
synonym: "UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197]
synonym: "uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.197]
xref: EC:2.4.1.197
xref: MetaCyc:2.4.1.197-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0033828
name: glucosylglycerol-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-glucose + sn-glycerol 3-phosphate = 2-(beta-D-glucosyl)-sn-glycerol 3-phosphate + ADP." [EC:2.4.1.213]
synonym: "ADP-glucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.213]
synonym: "ADPglucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.213]
synonym: "GG-phosphate synthase activity" EXACT [EC:2.4.1.213]
synonym: "GGPS" RELATED [EC:2.4.1.213]
synonym: "glucosyl-glycerol-phosphate synthase activity" EXACT [EC:2.4.1.213]
xref: EC:2.4.1.213
xref: MetaCyc:2.4.1.213-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033829
name: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor." [EC:2.4.1.222]
synonym: "O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.222]
synonym: "UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.222]
xref: EC:2.4.1.222
xref: MetaCyc:2.4.1.222-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0033830
name: Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylglucosamine + Skp1-protein-hydroxyproline = UDP + Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline." [EC:2.4.1.229]
synonym: "Skp1-HyPro GlcNAc-transferase activity" EXACT [EC:2.4.1.229]
synonym: "UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase activity" EXACT [EC:2.4.1.229]
synonym: "UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase activity" EXACT [EC:2.4.1.229]
synonym: "UDP-N-acetyl-D-glucosamine:Skp1-protein-hydroxyproline N-acetyl-D-glucosaminyl-transferase activity" EXACT [EC:2.4.1.229]
synonym: "UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase activity" EXACT [EC:2.4.1.229]
xref: EC:2.4.1.229
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0033831
name: kojibiose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-alpha-D-glucosyl-D-glucose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.230]
synonym: "2-alpha-D-glucosyl-D-glucose:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.230]
xref: EC:2.4.1.230
xref: MetaCyc:2.4.1.230-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033832
name: alpha,alpha-trehalose phosphorylase (configuration-retaining) activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate." [EC:2.4.1.231]
synonym: "alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.231]
synonym: "trehalose phosphorylase activity" BROAD [EC:2.4.1.231]
xref: MetaCyc:RXN-4441
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033833
name: hydroxymethylfurfural reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391]
is_a: GO:0033790 ! hydroxymethylfurfural reductase activity

[Term]
id: GO:0033834
name: kaempferol 3-O-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside." [EC:2.4.1.234]
synonym: "F3GalTase activity" EXACT [EC:2.4.1.234]
synonym: "UDP-galactose:kaempferol 3-O-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.234]
xref: EC:2.4.1.234
xref: MetaCyc:2.4.1.234-RXN
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0033835
name: flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-L-rhamnose + a flavanone 7-O-glucoside = UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside]." [EC:2.4.1.236]
synonym: "1->2 UDP-rhamnosyltransferase activity" EXACT [EC:2.4.1.236]
synonym: "UDP-L-rhamnose:flavanone-7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity" EXACT [EC:2.4.1.236]
synonym: "UDP-rhamnose:flavanone-7-O-glucoside-2''-O-rhamnosyltransferase activity" EXACT [EC:2.4.1.236]
xref: EC:2.4.1.236
xref: MetaCyc:RXN-5001
xref: MetaCyc:RXN-5002
xref: MetaCyc:RXN-5004
xref: MetaCyc:RXN-7759
xref: MetaCyc:RXN-9699
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0033836
name: flavonol 7-O-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside." [EC:2.4.1.237]
synonym: "UDP-glucose:flavonol 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.237]
synonym: "UDP-glucose:flavonol 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.237]
xref: EC:2.4.1.237
xref: MetaCyc:2.4.1.237-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033837
name: anthocyanin 3'-O-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + an anthocyanin = UDP + an anthocyanin 3'-O-beta-D-glucoside." [EC:2.4.1.238]
synonym: "3'GT" RELATED [EC:2.4.1.238]
synonym: "UDP-glucose:anthocyanin 3'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.238]
synonym: "UDP-glucose:anthocyanin 3'-O-glucosyltransferase activity" EXACT [EC:2.4.1.238]
xref: EC:2.4.1.238
xref: MetaCyc:2.4.1.238-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033838
name: flavonol-3-O-glucoside glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside." [EC:2.4.1.239]
synonym: "UDP-glucose:flavonol-3-O-glucoside 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.239]
xref: EC:2.4.1.239
xref: MetaCyc:2.4.1.239-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033839
name: flavonol-3-O-glycoside glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside." [EC:2.4.1.240]
synonym: "UDP-glucose:flavonol-3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside 2'''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.240]
xref: EC:2.4.1.240
xref: MetaCyc:2.4.1.240-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033840
name: NDP-glucose-starch glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NDP-glucose + (1,4-alpha-D-glucosyl)n = NDP + (1,4-alpha-D-glucosyl)n+1." [EC:2.4.1.242]
synonym: "GBSS" RELATED [EC:2.4.1.242]
synonym: "GBSSI" RELATED [EC:2.4.1.242]
synonym: "GBSSII" RELATED [EC:2.4.1.242]
synonym: "granule-bound starch synthase activity" EXACT [EC:2.4.1.242]
synonym: "granule-bound starch synthase I activity" EXACT [EC:2.4.1.242]
synonym: "granule-bound starch synthase II activity" EXACT [EC:2.4.1.242]
synonym: "NDP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.242]
synonym: "NDPglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.242]
synonym: "starch granule-bound nucleoside diphosphate glucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.242]
synonym: "starch synthase II activity" EXACT [EC:2.4.1.242]
synonym: "waxy protein" RELATED [EC:2.4.1.242]
xref: EC:2.4.1.242
xref: MetaCyc:2.4.1.242-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0033841
name: 6G-fructosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0)." [EC:2.4.1.243]
synonym: "1F-oligo[beta-D-fructofuranosyl-(2->1)-]sucrose 6G-beta-D-fructotransferase activity" EXACT [EC:2.4.1.243]
synonym: "6G-FFT" RELATED [EC:2.4.1.243]
synonym: "6G-fructotransferase activity" EXACT [EC:2.4.1.243]
synonym: "6G-FT" RELATED [EC:2.4.1.243]
synonym: "fructan:fructan 6G-fructosyltransferase activity" EXACT [EC:2.4.1.243]
xref: EC:2.4.1.243
xref: MetaCyc:2.4.1.243-RXN
is_a: GO:0050738 ! fructosyltransferase activity

[Term]
id: GO:0033842
name: N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group." [EC:2.4.1.244]
synonym: "beta1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.244]
synonym: "beta1,4-N-acetylgalactosaminyltransferase III activity" EXACT [EC:2.4.1.244]
synonym: "beta1,4-N-acetylgalactosaminyltransferase IV activity" EXACT [EC:2.4.1.244]
synonym: "beta4GalNAc-T3" RELATED [EC:2.4.1.244]
synonym: "beta4GalNAc-T4" RELATED [EC:2.4.1.244]
synonym: "UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.244]
xref: EC:2.4.1.244
xref: MetaCyc:2.4.1.244-RXN
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0033843
name: xyloglucan 6-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Transfers an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-1,6-D-xylosyl-D-glucose linkage." [EC:2.4.2.39]
synonym: "UDP-D-xylose:xyloglucan 1,6-alpha-D-xylosyltransferase activity" EXACT [EC:2.4.2.39]
synonym: "uridine diphosphoxylose-xyloglucan 6alpha-xylosyltransferase activity" EXACT [EC:2.4.2.39]
synonym: "xyloglucan 6-alpha-D-xylosyltransferase activity" EXACT [EC:2.4.2.39]
xref: EC:2.4.2.39
xref: MetaCyc:2.4.2.39-RXN
is_a: GO:0042285 ! xylosyltransferase activity

[Term]
id: GO:0033844
name: galactose-6-sulfurylase activity
namespace: molecular_function
def: "Catalysis of the reaction: Eliminates sulfate from the D-galactose 6-sulfate residues of porphyran, producing 3,6-anhydrogalactose residues." [EC:2.5.1.5]
synonym: "D-galactose-6-sulfate:alkyltransferase (cyclizing) activity" EXACT [EC:2.5.1.5]
synonym: "galactose 6-sulfatase activity" EXACT [EC:2.5.1.5]
synonym: "galactose-6-sulfatase activity" EXACT [EC:2.5.1.5]
synonym: "porphyran sulfatase activity" EXACT [EC:2.5.1.5]
xref: EC:2.5.1.5
xref: MetaCyc:2.5.1.5-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033845
name: hydroxymethylfurfural reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391]
is_a: GO:0033790 ! hydroxymethylfurfural reductase activity

[Term]
id: GO:0033846
name: adenosyl-fluoride synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine." [EC:2.5.1.63]
synonym: "fluorinase activity" EXACT [EC:2.5.1.63]
synonym: "S-adenosyl-L-methionine:fluoride adenosyltransferase activity" EXACT [EC:2.5.1.63]
xref: EC:2.5.1.63
xref: MetaCyc:2.5.1.63-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033847
name: O-phosphoserine sulfhydrylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate." [EC:2.5.1.65]
synonym: "O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.65]
synonym: "O-phosphoserine(thiol)-lyase activity" EXACT [EC:2.5.1.65]
xref: EC:2.5.1.65
xref: MetaCyc:2.5.1.65-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033848
name: N2-(2-carboxyethyl)arginine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + L-arginine = N2-(2-carboxyethyl)-L-arginine + phosphate." [EC:2.5.1.66]
synonym: "CEA synthetase activity" EXACT [EC:2.5.1.66]
synonym: "CEAS" RELATED [EC:2.5.1.66]
synonym: "glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity" EXACT [EC:2.5.1.66]
synonym: "glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity" EXACT [EC:2.5.1.66]
synonym: "N2-(2-carboxyethyl)arginine synthetase activity" EXACT [EC:2.5.1.66]
xref: EC:2.5.1.66
xref: MetaCyc:2.5.1.66-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033849
name: chrysanthemyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + chrysanthemyl diphosphate." [EC:2.5.1.67]
synonym: "CPPase activity" EXACT [EC:2.5.1.67]
synonym: "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (chrysanthemyl-diphosphate-forming) activity" EXACT [EC:2.5.1.67]
xref: EC:2.5.1.67
xref: MetaCyc:2.5.1.67-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033850
name: Z-farnesyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6E)-farnesyl diphosphate." [EC:2.5.1.68]
synonym: "(Z)-farnesyl diphosphate synthase activity" EXACT [EC:2.5.1.68]
synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase activity" EXACT [EC:2.5.1.68]
xref: EC:2.5.1.68
xref: MetaCyc:2.5.1.68-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033851
name: lavandulyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate." [EC:2.5.1.69]
synonym: "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (lavandulyl-diphosphate-forming) activity" EXACT [EC:2.5.1.69]
synonym: "FDS-5" RELATED [EC:2.5.1.69]
xref: EC:2.5.1.69
xref: MetaCyc:2.5.1.69-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0033852
name: thyroid-hormone transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-3,5,3'-triiodothyronine + 2-oxoglutarate = 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate." [EC:2.6.1.26]
synonym: "3,5-dinitrotyrosine aminotransferase activity" EXACT [EC:2.6.1.26]
synonym: "3,5-dinitrotyrosine transaminase activity" EXACT [EC:2.6.1.26]
synonym: "L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.26]
synonym: "thyroid hormone aminotransferase activity" EXACT [EC:2.6.1.26]
synonym: "thyroid-hormone aminotransferase activity" EXACT [EC:2.6.1.26]
xref: EC:2.6.1.26
xref: MetaCyc:THYROID-HORMONE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0033853
name: aspartate-prephenate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arogenate + oxaloacetate = prephenate + L-aspartate." [EC:2.6.1.78]
synonym: "L-arogenate:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.78]
synonym: "L-aspartate:prephenate aminotransferase activity" EXACT [EC:2.6.1.78]
synonym: "PAT" RELATED [EC:2.6.1.78]
synonym: "prephenate aspartate aminotransferase activity" EXACT [EC:2.6.1.78]
synonym: "prephenate transaminase activity" BROAD [EC:2.6.1.78]
xref: EC:2.6.1.78
xref: MetaCyc:PREPHENATE-ASP-TRANSAMINE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0033854
name: glutamate-prephenate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arogenate + 2-oxoglutarate = prephenate + L-glutamate." [EC:2.6.1.79]
synonym: "L-arogenate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.79]
synonym: "L-glutamate:prephenate aminotransferase activity" EXACT [EC:2.6.1.79]
synonym: "PAT" RELATED [EC:2.6.1.79]
synonym: "prephenate transaminase activity" BROAD [EC:2.6.1.79]
xref: EC:2.6.1.79
xref: MetaCyc:PREPHENATE-TRANSAMINE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0033855
name: nicotianamine aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotianamine + 2-oxoglutarate = 3''-deamino-3''-oxonicotianamine + L-glutamate." [EC:2.6.1.80]
synonym: "NAAT" RELATED [EC:2.6.1.80]
synonym: "NAAT-I" RELATED [EC:2.6.1.80]
synonym: "NAAT-II" RELATED [EC:2.6.1.80]
synonym: "NAAT-III" RELATED [EC:2.6.1.80]
synonym: "nicotianamine transaminase activity" EXACT [EC:2.6.1.80]
synonym: "nicotianamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.80]
xref: EC:2.6.1.80
xref: MetaCyc:2.6.1.80-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0033856
name: pyridoxine 5'-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O." [EC:2.6.99.2]
synonym: "1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing) activity" EXACT [EC:2.6.99.2]
synonym: "PdxJ" RELATED [EC:2.6.99.2]
synonym: "PNP synthase activity" EXACT [EC:2.6.99.2]
synonym: "pyridoxine 5-phosphate phospho lyase activity" EXACT [EC:2.6.99.2]
xref: EC:2.6.99.2
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups

[Term]
id: GO:0033857
name: diphosphoinositol-pentakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)." [EC:2.7.4.24]
synonym: "ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase activity" EXACT [EC:2.7.4.24]
synonym: "PP-InsP5 kinase activity" EXACT [EC:2.7.4.24]
synonym: "PP-IP5 kinase activity" EXACT [EC:2.7.4.24]
synonym: "PPIP5K" RELATED [EC:2.7.4.24]
synonym: "PPIP5K1" RELATED [EC:2.7.4.24]
synonym: "PPIP5K2" RELATED [EC:2.7.4.24]
synonym: "VIP1" NARROW [EC:2.7.4.24]
synonym: "VIP2" NARROW [EC:2.7.4.24]
xref: EC:2.7.4.24
xref: MetaCyc:2.7.1.155-RXN
xref: MetaCyc:2.7.4.24-RXN
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0033858
name: N-acetylgalactosamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate." [EC:2.7.1.157]
synonym: "ATP:N-acetyl-D-galactosamine 1-phosphotransferase activity" EXACT [EC:2.7.1.157]
synonym: "GALK2" RELATED [EC:2.7.1.157]
synonym: "GalNAc kinase activity" EXACT [EC:2.7.1.157]
synonym: "GK2" RELATED [EC:2.7.1.157]
synonym: "N-acetylgalactosamine (GalNAc)-1-phosphate kinase activity" EXACT [EC:2.7.1.157]
xref: EC:2.7.1.157
xref: MetaCyc:2.7.1.157-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0033859
name: furaldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving furaldehyde, a furan ring-containing aldehyde compound which can be formed from the thermal decomposition of biomass." [GOC:jp, PMID:15338422, PMID:16652391]
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0033860
name: regulation of NAD(P)H oxidase activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme NAD(P)H oxidase." [GOC:mah]
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:0033861
name: negative regulation of NAD(P)H oxidase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme NAD(P)H oxidase." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of NAD(P)H oxidase activity" EXACT []
synonym: "down-regulation of NAD(P)H oxidase activity" EXACT []
synonym: "downregulation of NAD(P)H oxidase activity" EXACT []
synonym: "inhibition of NAD(P)H oxidase activity" NARROW []
is_a: GO:0033860 ! regulation of NAD(P)H oxidase activity
is_a: GO:0051354 ! negative regulation of oxidoreductase activity

[Term]
id: GO:0033862
name: UMP kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + UMP = ADP + UDP." [EC:2.7.4.22]
synonym: "ATP:UMP phosphotransferase activity" EXACT [EC:2.7.4.22]
synonym: "PyrH" RELATED [EC:2.7.4.22]
synonym: "SmbA" RELATED [EC:2.7.4.22]
synonym: "UMP-kinase activity" EXACT [EC:2.7.4.22]
synonym: "UMPK" RELATED [EC:2.7.4.22]
synonym: "uridine monophosphate kinase activity" EXACT [EC:2.7.4.22]
xref: EC:2.7.4.22
xref: MetaCyc:2.7.4.22-RXN
is_a: GO:0009041 ! uridylate kinase activity

[Term]
id: GO:0033863
name: ribose 1,5-bisphosphate phosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + ribose 1,5-bisphosphate = ADP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.7.4.23]
synonym: "ATP:ribose-1,5-bisphosphate phosphotransferase activity" EXACT [EC:2.7.4.23]
synonym: "PhnN" RELATED [EC:2.7.4.23]
synonym: "ribose 1,5-bisphosphokinase activity" EXACT [EC:2.7.4.23]
xref: EC:2.7.4.23
xref: MetaCyc:2.7.4.23-RXN
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0033864
name: positive regulation of NAD(P)H oxidase activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme NAD(P)H oxidase." [GOC:mah]
subset: gosubset_prok
synonym: "activation of NAD(P)H oxidase activity" NARROW []
synonym: "stimulation of NAD(P)H oxidase activity" NARROW []
synonym: "up regulation of NAD(P)H oxidase activity" EXACT []
synonym: "up-regulation of NAD(P)H oxidase activity" EXACT []
synonym: "upregulation of NAD(P)H oxidase activity" EXACT []
is_a: GO:0033860 ! regulation of NAD(P)H oxidase activity
is_a: GO:0051353 ! positive regulation of oxidoreductase activity

[Term]
id: GO:0033865
name: nucleoside bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a nucleoside bisphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd]
subset: gosubset_prok
synonym: "nucleoside bisphosphate metabolism" EXACT []
is_a: GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0033866
name: nucleoside bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleoside bisphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd]
subset: gosubset_prok
synonym: "nucleoside bisphosphate anabolism" EXACT []
synonym: "nucleoside bisphosphate biosynthesis" EXACT []
synonym: "nucleoside bisphosphate formation" EXACT []
synonym: "nucleoside bisphosphatehate synthesis" EXACT []
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0033865 ! nucleoside bisphosphate metabolic process

[Term]
id: GO:0033867
name: Fas-activated serine/threonine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein." [EC:2.7.11.8]
synonym: "ATP:Fas-activated serine/threonine protein phosphotransferase activity" EXACT [EC:2.7.11.8]
synonym: "FAST" RELATED [EC:2.7.11.8]
synonym: "FASTK" RELATED [EC:2.7.11.8]
synonym: "STK10" RELATED [EC:2.7.11.8]
xref: EC:2.7.11.8
xref: MetaCyc:2.7.11.8-RXN
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0033868
name: Goodpasture-antigen-binding protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + Goodpasture antigen-binding protein = ADP + Goodpasture antigen-binding phosphoprotein." [EC:2.7.11.9]
synonym: "ATP:Goodpasture antigen-binding protein phosphotransferase activity" EXACT [EC:2.7.11.9]
synonym: "Goodpasture antigen-binding protein kinase activity" EXACT [EC:2.7.11.9]
synonym: "GPBP kinase activity" EXACT [EC:2.7.11.9]
synonym: "GPBPK" RELATED [EC:2.7.11.9]
synonym: "STK11" RELATED [EC:2.7.11.9]
xref: EC:2.7.11.9
xref: MetaCyc:2.7.11.9-RXN
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0033869
name: nucleoside bisphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside bisphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd]
subset: gosubset_prok
synonym: "nucleoside bisphosphate breakdown" EXACT []
synonym: "nucleoside bisphosphate catabolism" EXACT []
synonym: "nucleoside bisphosphate degradation" EXACT []
is_a: GO:0009166 ! nucleotide catabolic process
is_a: GO:0033865 ! nucleoside bisphosphate metabolic process

[Term]
id: GO:0033870
name: thiol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate." [EC:2.8.2.16]
synonym: "3'-phosphoadenylyl-sulfate:thiol S-sulfotransferase activity" EXACT [EC:2.8.2.16]
synonym: "adenosine 3'-phosphate 5'-sulphatophosphate sulfotransferase activity" EXACT [EC:2.8.2.16]
synonym: "PAPS sulfotransferase activity" BROAD [EC:2.8.2.16]
xref: EC:2.8.2.16
xref: MetaCyc:THIOL-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0033871
name: [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S." [EC:2.8.2.29]
synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.29]
synonym: "3-OST-2" RELATED [EC:2.8.2.29]
synonym: "glucosaminyl 3-O-sulfotransferase 2 activity" EXACT [EC:2.8.2.29]
synonym: "glucosaminyl 3-O-sulfotransferase activity" BROAD [EC:2.8.2.29]
synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 activity" EXACT [EC:2.8.2.29]
synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" BROAD [EC:2.8.2.29]
synonym: "heparin-glucosamine 3-sulfotransferase 2 activity" RELATED []
synonym: "isoform/isozyme 2 (3-OST-2, HS3ST2)" RELATED [EC:2.8.2.29]
xref: EC:2.8.2.29
xref: MetaCyc:2.8.2.29-RXN
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0033872
name: [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate." [EC:2.8.2.30]
synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.30]
synonym: "3-OST-3" RELATED [EC:2.8.2.30]
synonym: "glucosaminyl 3-O-sulfotransferase 3 activity" EXACT [EC:2.8.2.30]
synonym: "glucosaminyl 3-O-sulfotransferase 3a, 3b activity" EXACT [EC:2.8.2.30]
synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 activity" EXACT [EC:2.8.2.30]
synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A activity" EXACT [EC:2.8.2.30]
synonym: "heparin-glucosamine 3-sulfotransferase 3 activity" RELATED []
synonym: "isoform/isozyme 3a and 3b (3-OST-3A, 3-OST-3B, HS3ST3A, HS3ST3B)" RELATED [EC:2.8.2.30]
xref: EC:2.8.2.30
xref: MetaCyc:2.8.2.23-RXN
xref: MetaCyc:2.8.2.29-RXN
xref: MetaCyc:2.8.2.30-RXN
is_a: GO:0034483 ! heparan sulfate sulfotransferase activity

[Term]
id: GO:0033873
name: petromyzonol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + 5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol = adenosine 3',5'-bisphosphate + 5alpha-cholan-3alpha,7alpha,12alpha-triol 24-sulfate." [EC:2.8.2.31]
synonym: "3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfotransferase activity" EXACT [EC:2.8.2.31]
synonym: "PZ-SULT" RELATED [EC:2.8.2.31]
xref: EC:2.8.2.31
xref: MetaCyc:2.8.2.31-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0033874
name: scymnol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + 5beta-scymnol = adenosine 3',5'-bisphosphate + 5beta-scymnol sulfate." [EC:2.8.2.32]
xref: EC:2.8.2.32
xref: MetaCyc:2.8.2.32-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0033875
name: ribonucleoside bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a ribonucleoside bisphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd]
subset: gosubset_prok
synonym: "ribonucleoside bisphosphate metabolism" EXACT []
is_a: GO:0033865 ! nucleoside bisphosphate metabolic process

[Term]
id: GO:0033876
name: glycochenodeoxycholate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate." [EC:2.8.2.34]
synonym: "3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase activity" EXACT [EC:2.8.2.34]
synonym: "BAST" RELATED [EC:2.8.2.34]
synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" BROAD [EC:2.8.2.34]
synonym: "bile acid:PAPS:sulfotransferase activity" EXACT [EC:2.8.2.34]
xref: EC:2.8.2.34
xref: MetaCyc:2.8.2.34-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0033877
name: succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity
namespace: molecular_function
alt_id: GO:0018728
def: "Catalysis of the reaction: succinyl-CoA + (R)-2-benzylsuccinate = succinate + (R)-2-benzylsuccinyl-CoA." [EC:2.8.3.15]
synonym: "benzylsuccinate CoA-transferase activity" EXACT [EC:2.8.3.15]
synonym: "succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase activity" EXACT [EC:2.8.3.15]
synonym: "succinyl-CoA:benzylsuccinate CoA-transferase activity" EXACT []
xref: EC:2.8.3.15
xref: MetaCyc:RXN-864
xref: UM-BBD_enzymeID:e0260
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0033878
name: hormone-sensitive lipase activity
namespace: molecular_function
def: "Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate, triacylglycerol + H2O = diacylglycerol + a carboxylate, and monoacylglycerol + H2O = glycerol + a carboxylate." [EC:3.1.1.79]
synonym: "diacylglycerol acylhydrolase activity" EXACT [EC:3.1.1.79]
synonym: "HSL" RELATED [EC:3.1.1.79]
xref: EC:3.1.1.79
xref: MetaCyc:STEROL-ESTERASE-RXN
xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0033879
name: acetylajmaline esterase activity
namespace: molecular_function
def: "Catalysis of the reactions: 17-O-acetylajmaline + H2O = ajmaline + acetate and 17-O-acetylnorajmaline + H2O = norajmaline + acetate." [EC:3.1.1.80]
synonym: "17-O-acetylajmaline O-acetylhydrolase activity" EXACT [EC:3.1.1.80]
synonym: "2beta(R)-17-O-acetylajmalan:acetylesterase activity" EXACT [EC:3.1.1.80]
synonym: "AAE" RELATED [EC:3.1.1.80]
synonym: "acetylajmalan esterase activity" EXACT [EC:3.1.1.80]
xref: EC:3.1.1.80
xref: MetaCyc:RXN-8652
xref: MetaCyc:RXN-8653
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0033880
name: phenylacetyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylglyoxylyl-CoA + H2O = phenylglyoxylate + CoA." [EC:3.1.2.25]
synonym: "phenylglyoxylyl-CoA hydrolase activity" EXACT [EC:3.1.2.25]
xref: EC:3.1.2.25
xref: MetaCyc:3.1.2.25-RXN
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0033881
name: bile-acid-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxycholoyl-CoA + H2O = CoA + deoxycholate." [EC:3.1.2.26]
synonym: "bile acid-coenzyme A hydrolase activity" EXACT [EC:3.1.2.26]
synonym: "deoxycholoyl-CoA hydrolase activity" EXACT [EC:3.1.2.26]
xref: EC:3.1.2.26
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0033882
name: choloyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA." [EC:3.1.2.27]
synonym: "chenodeoxycholoyl-coenzyme A thioesterase activity" EXACT [EC:3.1.2.27]
synonym: "choloyl-coenzyme A thioesterase activity" EXACT [EC:3.1.2.27]
synonym: "peroxisomal acyl-CoA thioesterase 2 activity" NARROW [EC:3.1.2.27]
synonym: "PTE-2" RELATED [EC:3.1.2.27]
xref: EC:3.1.2.27
xref: MetaCyc:3.1.2.27-RXN
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0033883
name: pyridoxal phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate." [EC:3.1.3.74]
synonym: "PLP phosphatase activity" EXACT [EC:3.1.3.74]
synonym: "PNP phosphatase activity" EXACT [EC:3.1.3.74]
synonym: "pyridoxal-5'-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.74]
synonym: "vitamin B6-phosphate phosphatase activity" BROAD [EC:3.1.3.74]
synonym: "vitamine B6 (pyridoxine) phosphatase activity" BROAD [EC:3.1.3.74]
xref: EC:3.1.3.74
xref: MetaCyc:3.1.3.74-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0033884
name: phosphoethanolamine/phosphocholine phosphatase activity
namespace: molecular_function
def: "Catalysis of the reactions: O-phosphoethanolamine + H2O = ethanolamine + phosphate and phosphocholine + H2O = choline + phosphate." [EC:3.1.3.75]
synonym: "3X11A" RELATED [EC:3.1.3.75]
synonym: "PHOSPHO1" RELATED [EC:3.1.3.75]
synonym: "phosphoethanolamine phosphohydrolase activity" EXACT [EC:3.1.3.75]
xref: EC:3.1.3.75
xref: MetaCyc:RXN-5647
xref: MetaCyc:RXN-7948
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0033885
name: lipid-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate." [EC:3.1.3.76]
synonym: "(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase activity" EXACT [EC:3.1.3.76]
synonym: "dihydroxy fatty acid phosphatase activity" EXACT [EC:3.1.3.76]
synonym: "hydroxy fatty acid phosphatase activity" EXACT [EC:3.1.3.76]
synonym: "hydroxy lipid phosphatase activity" EXACT [EC:3.1.3.76]
synonym: "sEH" RELATED [EC:3.1.3.76]
synonym: "soluble epoxide hydrolase activity" RELATED [EC:3.1.3.76]
xref: EC:3.1.3.76
xref: MetaCyc:3.1.3.76-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0033886
name: cellulose-polysulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of the 2- and 3-sulfate groups of the polysulfates of cellulose and charonin." [EC:3.1.6.7]
synonym: "cellulose-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.7]
xref: EC:3.1.6.7
xref: MetaCyc:3.1.6.7-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0033887
name: chondro-4-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine + sulfate." [EC:3.1.6.9]
synonym: "4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" EXACT [EC:3.1.6.9]
xref: EC:3.1.6.9
xref: MetaCyc:CHONDRO-4-SULFATASE-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0033888
name: chondro-6-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 6-sulfate + H2O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine + sulfate." [EC:3.1.6.10]
synonym: "4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity" EXACT [EC:3.1.6.10]
xref: EC:3.1.6.10
xref: MetaCyc:CHONDRO-6-SULFATASE-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0033889
name: N-sulfoglucosamine-3-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin." [EC:3.1.6.15]
synonym: "chondroitinsulfatase activity" BROAD [EC:3.1.6.15]
synonym: "N-sulfo-3-sulfoglucosamine 3-sulfohydrolase activity" EXACT [EC:3.1.6.15]
xref: EC:3.1.6.15
xref: MetaCyc:3.1.6.15-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0033890
name: ribonuclease D activity
namespace: molecular_function
def: "Catalysis of the reaction: exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides." [EC:3.1.13.5]
synonym: "RNase D activity" EXACT [EC:3.1.13.5]
xref: EC:3.1.13.5
xref: MetaCyc:3.1.13.5-RXN
is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033891
name: CC-preferring endodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the reaction: endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC." [EC:3.1.21.6]
synonym: "5'-CC-3'-preferring endodeoxyribonuclease activity" EXACT [EC:3.1.21.6]
synonym: "Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease activity" EXACT [EC:3.1.21.6]
synonym: "Streptomyces glaucescens exocytoplasmic endodeoxyribonuclease activity" EXACT [EC:3.1.21.6]
synonym: "Streptomyces glaucescens exocytoplasmic endonuclease activity" EXACT [EC:3.1.21.6]
xref: EC:3.1.21.6
xref: MetaCyc:3.1.21.6-RXN
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033892
name: deoxyribonuclease (pyrimidine dimer) activity
namespace: molecular_function
def: "Catalysis of the reaction: endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate." [EC:3.1.25.1]
synonym: "bacteriophage T4 endodeoxyribonuclease V activity" EXACT [EC:3.1.25.1]
synonym: "endodeoxyribonuclease (pyrimidine dimer) activity" EXACT [EC:3.1.25.1]
synonym: "T4 endonuclease V activity" EXACT [EC:3.1.25.1]
xref: EC:3.1.25.1
xref: MetaCyc:3.1.25.1-RXN
is_a: GO:0016890 ! site-specific endodeoxyribonuclease activity, specific for altered base

[Term]
id: GO:0033893
name: ribonuclease IV activity
namespace: molecular_function
def: "Catalysis of the reaction: endonucleolytic cleavage of poly(A) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.6]
synonym: "endoribonuclease IV activity" EXACT [EC:3.1.26.6]
xref: EC:3.1.26.6
xref: MetaCyc:3.1.26.6-RXN
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033894
name: ribonuclease P4 activity
namespace: molecular_function
def: "Catalysis of the reaction: endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor." [EC:3.1.26.7]
xref: EC:3.1.26.7
xref: MetaCyc:3.1.26.7-RXN
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033895
name: ribonuclease [poly-(U)-specific] activity
namespace: molecular_function
def: "Catalysis of the reaction: endonucleolytic cleavage of poly(U) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.9]
synonym: "ribonuclease (uracil-specific) activity" EXACT [EC:3.1.26.9]
synonym: "uracil-specific endoribonuclease activity" EXACT [EC:3.1.26.9]
synonym: "uracil-specific RNase activity" EXACT [EC:3.1.26.9]
xref: EC:3.1.26.9
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033896
name: ribonuclease IX activity
namespace: molecular_function
def: "Catalysis of the reaction: endonucleolytic cleavage of poly(U) or poly(C) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.10]
synonym: "poly(U)- and poly(C)-specific endoribonuclease activity" EXACT [EC:3.1.26.10]
xref: EC:3.1.26.10
xref: MetaCyc:3.1.26.10-RXN
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0033897
name: ribonuclease T2 activity
namespace: molecular_function
def: "Catalysis of the reaction: two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.1]
synonym: "acid ribonuclease activity" EXACT [EC:3.1.27.1]
synonym: "acid RNase activity" EXACT [EC:3.1.27.1]
synonym: "base-non-specific ribonuclease activity" EXACT [EC:3.1.27.1]
synonym: "Escherichia coli ribonuclease I' ribonuclease PP2 activity" EXACT [EC:3.1.27.1]
synonym: "Escherichia coli ribonuclease II activity" EXACT [EC:3.1.27.1]
synonym: "non-base specific ribonuclease activity" EXACT [EC:3.1.27.1]
synonym: "nonbase-specific RNase activity" EXACT [EC:3.1.27.1]
synonym: "nonspecific RNase activity" EXACT [EC:3.1.27.1]
synonym: "ribonnuclease (non-base specific) activity" EXACT [EC:3.1.27.1]
synonym: "ribonuclease (non-base specific) activity" EXACT [EC:3.1.27.1]
synonym: "ribonuclease II activity" BROAD [EC:3.1.27.1]
synonym: "ribonuclease M activity" EXACT [EC:3.1.27.1]
synonym: "ribonuclease N2 activity" EXACT [EC:3.1.27.1]
synonym: "ribonuclease PP3 activity" EXACT [EC:3.1.27.1]
synonym: "ribonuclease U4 activity" EXACT [EC:3.1.27.1]
synonym: "ribonucleate 3'-oligonucleotide hydrolase activity" EXACT [EC:3.1.27.1]
synonym: "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD [EC:3.1.27.1]
synonym: "RNAase CL activity" EXACT [EC:3.1.27.1]
synonym: "RNase (non-base specific) activity" EXACT [EC:3.1.27.1]
synonym: "RNase II activity" BROAD [EC:3.1.27.1]
synonym: "RNase M activity" EXACT [EC:3.1.27.1]
synonym: "RNase Ms activity" EXACT [EC:3.1.27.1]
synonym: "RNase T2 activity" EXACT [EC:3.1.27.1]
xref: EC:3.1.27.1
xref: MetaCyc:3.1.27.1-RXN
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0033898
name: Bacillus subtilis ribonuclease activity
namespace: molecular_function
def: "Catalysis of the reaction: endonucleolytic cleavage to 2',3'-cyclic nucleotides." [EC:3.1.27.2]
synonym: "proteus mirabilis RNase activity" EXACT [EC:3.1.27.2]
synonym: "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD [EC:3.1.27.2]
xref: EC:3.1.27.2
xref: MetaCyc:3.1.27.2-RXN
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0033899
name: ribonuclease U2 activity
namespace: molecular_function
def: "Catalysis of the reaction: two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.4]
synonym: "pleospora RNase activity" EXACT [EC:3.1.27.4]
synonym: "purine specific endoribonuclease activity" EXACT [EC:3.1.27.4]
synonym: "purine-specific ribonuclease activity" EXACT [EC:3.1.27.4]
synonym: "purine-specific RNase activity" EXACT [EC:3.1.27.4]
synonym: "ribonuclease (purine) activity" EXACT [EC:3.1.27.4]
synonym: "ribonuclease U3 activity" EXACT [EC:3.1.27.4]
synonym: "RNase U3 activity" EXACT [EC:3.1.27.4]
synonym: "trichoderma koningi RNase III activity" EXACT [EC:3.1.27.4]
xref: EC:3.1.27.4
xref: MetaCyc:3.1.27.4-RXN
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0033900
name: ribonuclease F activity
namespace: molecular_function
def: "Catalysis of the reaction: endonucleolytic cleavage of RNA precursor into two, leaving 5'-hydroxy and 3'-phosphate groups." [EC:3.1.27.7]
synonym: "ribonuclease F (E. coli) activity" EXACT [EC:3.1.27.7]
synonym: "RNase F activity" EXACT [EC:3.1.27.7]
xref: EC:3.1.27.7
xref: MetaCyc:3.1.27.7-RXN
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0033901
name: ribonuclease V activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP." [EC:3.1.27.8]
synonym: "endoribonuclease V activity" EXACT [EC:3.1.27.8]
xref: EC:3.1.27.8
xref: MetaCyc:3.1.27.8-RXN
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0033902
name: rRNA endonuclease activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes." [EC:3.1.27.10]
synonym: "alpha-sarcin" RELATED [EC:3.1.27.10]
xref: EC:3.1.27.10
xref: MetaCyc:3.1.27.10-RXN
is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters

[Term]
id: GO:0033903
name: endo-1,3(4)-beta-glucanase activity
namespace: molecular_function
def: "Catalysis of the reaction: endohydrolysis of 1,3- or 1,4-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3." [EC:3.2.1.6]
synonym: "1,3-(1,3;1,4)-beta-D-glucan 3(4)-glucanohydrolase activity" EXACT [EC:3.2.1.6]
synonym: "beta-1,3-1,4-glucanase activity" EXACT [EC:3.2.1.6]
synonym: "beta-1,3-glucanase activity" BROAD [EC:3.2.1.6]
synonym: "endo-1,3-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.6]
synonym: "endo-1,3-beta-D-glucanase activity" BROAD [EC:3.2.1.6]
synonym: "endo-1,3-beta-glucanase activity" BROAD [EC:3.2.1.6]
synonym: "endo-1,4-beta-glucanase activity" BROAD [EC:3.2.1.6]
synonym: "endo-beta-(1-3)-D-glucanase activity" BROAD [EC:3.2.1.6]
synonym: "endo-beta-(1->3)-D-glucanase activity" BROAD [EC:3.2.1.6]
synonym: "endo-beta-1,3(4)-glucanase activity" EXACT [EC:3.2.1.6]
synonym: "endo-beta-1,3-1,4-glucanase activity" EXACT [EC:3.2.1.6]
synonym: "endo-beta-1,3-glucanase IV activity" EXACT [EC:3.2.1.6]
synonym: "laminaranase activity" BROAD [EC:3.2.1.6]
synonym: "laminarinase activity" BROAD [EC:3.2.1.6]
xref: EC:3.2.1.6
xref: MetaCyc:3.2.1.6-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033904
name: dextranase activity
namespace: molecular_function
def: "Catalysis of the reaction: endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran." [EC:3.2.1.11]
synonym: "1,6-alpha-D-glucan 6-glucanohydrolase activity" EXACT [EC:3.2.1.11]
synonym: "alpha-1,6-glucan-6-glucanohydrolase activity" EXACT [EC:3.2.1.11]
synonym: "alpha-D-1,6-glucan-6-glucanohydrolase activity" EXACT [EC:3.2.1.11]
synonym: "dextran hydrolase activity" EXACT [EC:3.2.1.11]
synonym: "dextranase DL 2 activity" NARROW [EC:3.2.1.11]
synonym: "DL 2" RELATED [EC:3.2.1.11]
synonym: "endo-dextranase activity" EXACT [EC:3.2.1.11]
synonym: "endodextranase activity" EXACT [EC:3.2.1.11]
xref: EC:3.2.1.11
xref: MetaCyc:3.2.1.11-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033905
name: xylan endo-1,3-beta-xylosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: random hydrolysis of 1,3-beta-D-glycosidic linkages in 1,3-beta-D-xylans." [EC:3.2.1.32]
synonym: "1,3-beta-D-xylan xylanohydrolase activity" EXACT [EC:3.2.1.32]
synonym: "1,3-beta-xylanase activity" EXACT [EC:3.2.1.32]
synonym: "1,3-xylanase activity" EXACT [EC:3.2.1.32]
synonym: "beta-1,3-xylanase activity" EXACT [EC:3.2.1.32]
synonym: "endo-1,3-beta-xylanase activity" EXACT [EC:3.2.1.32]
synonym: "endo-1,3-xylanase activity" EXACT [EC:3.2.1.32]
synonym: "endo-beta-1,3-xylanase activity" EXACT [EC:3.2.1.32]
synonym: "xylanase activity" BROAD [EC:3.2.1.32]
xref: EC:3.2.1.32
xref: MetaCyc:3.2.1.32-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033906
name: hyaluronoglucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate." [EC:3.2.1.36]
synonym: "glucuronoglucosaminoglycan hyaluronate lyase activity" EXACT [EC:3.2.1.36]
synonym: "hyaluronate 3-glycanohydrolase activity" EXACT [EC:3.2.1.36]
synonym: "hyaluronidase activity" BROAD [EC:3.2.1.36]
synonym: "orgelase activity" EXACT [EC:3.2.1.36]
xref: EC:3.2.1.36
xref: MetaCyc:3.2.1.36-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033907
name: beta-D-fucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides." [EC:3.2.1.38]
synonym: "beta-D-fucoside fucohydrolase activity" EXACT [EC:3.2.1.38]
synonym: "beta-fucosidase activity" EXACT [EC:3.2.1.38]
xref: EC:3.2.1.38
xref: MetaCyc:3.2.1.38-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033908
name: beta-L-rhamnosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides." [EC:3.2.1.43]
synonym: "beta-L-rhamnoside rhamnohydrolase activity" EXACT [EC:3.2.1.43]
xref: EC:3.2.1.43
xref: MetaCyc:3.2.1.43-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033909
name: fucoidanase activity
namespace: molecular_function
def: "Catalysis of the reaction: endohydrolysis of 1,2-alpha-L-fucoside linkages in fucoidan without release of sulfate." [EC:3.2.1.44]
synonym: "poly(1,2-alpha-L-fucoside-4-sulfate) glycanohydrolase activity" EXACT [EC:3.2.1.44]
xref: EC:3.2.1.44
xref: MetaCyc:3.2.1.44-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033910
name: glucan 1,4-alpha-maltotetraohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends." [EC:3.2.1.60]
synonym: "1,4-alpha-D-glucan maltotetraohydrolase activity" EXACT [EC:3.2.1.60]
synonym: "exo-maltotetraohydrolase activity" EXACT [EC:3.2.1.60]
synonym: "G4-amylase activity" EXACT [EC:3.2.1.60]
synonym: "glucan 1,4-alpha-maltotetrahydrolase activity" EXACT [EC:3.2.1.60]
synonym: "maltotetraose-forming amylase activity" EXACT [EC:3.2.1.60]
xref: EC:3.2.1.60
xref: MetaCyc:3.2.1.60-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033911
name: mycodextranase activity
namespace: molecular_function
def: "Catalysis of the reaction: endohydrolysis of 1,4-alpha-D-glucosidic linkages in alpha-D-glucans containing both 1,3- and 1,4-bonds." [EC:3.2.1.61]
synonym: "1,3-1,4-alpha-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.61]
xref: EC:3.2.1.61
xref: MetaCyc:3.2.1.61-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033912
name: 2,6-beta-fructan 6-levanbiohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of 2,6-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain." [EC:3.2.1.64]
synonym: "2,6-beta-D-fructan 6-beta-D-fructofuranosylfructohydrolase activity" EXACT [EC:3.2.1.64]
synonym: "2,6-beta-D-fructan 6-levanbiohydrolase activity" EXACT [EC:3.2.1.64]
synonym: "2,6-beta-D-fructofuranan 6-(beta-D-fructosyl)-D-fructose-hydrolase activity" EXACT [EC:3.2.1.64]
synonym: "beta-2,6-fructan-6-levanbiohydrolase activity" EXACT [EC:3.2.1.64]
synonym: "levanbiose-producing levanase activity" EXACT [EC:3.2.1.64]
xref: EC:3.2.1.64
xref: MetaCyc:3.2.1.64-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033913
name: glucan endo-1,2-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: random hydrolysis of 1,2-glucosidic linkages in 1,2-beta-D-glucans." [EC:3.2.1.71]
synonym: "1,2-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.71]
synonym: "beta-D-1,2-glucanase activity" EXACT [EC:3.2.1.71]
synonym: "endo-(1->2)-beta-D-glucanase activity" EXACT [EC:3.2.1.71]
synonym: "endo-1,2-beta-glucanase activity" EXACT [EC:3.2.1.71]
xref: EC:3.2.1.71
xref: MetaCyc:3.2.1.71-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033914
name: xylan 1,3-beta-xylosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of successive xylose residues from the non-reducing termini of 1,3-beta-D-xylans." [EC:3.2.1.72]
synonym: "1,3-beta-D-xylan xylohydrolase activity" EXACT [EC:3.2.1.72]
synonym: "1,3-beta-D-xylosidase, exo-1,3-beta-xylosidase activity" EXACT [EC:3.2.1.72]
synonym: "beta-1,3'-xylanase activity" EXACT [EC:3.2.1.72]
synonym: "exo-1,3-beta-xylosidase activity" EXACT [EC:3.2.1.72]
synonym: "exo-beta-1,3'-xylanase activity" EXACT [EC:3.2.1.72]
xref: EC:3.2.1.72
xref: MetaCyc:3.2.1.72-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033915
name: mannan 1,2-(1,3)-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of 1,2- and 1,3-linkages in yeast mannan, releasing mannose." [EC:3.2.1.77]
synonym: "1,2-1,3-alpha-D-mannan mannohydrolase activity" EXACT [EC:3.2.1.77]
synonym: "exo-1,2-1,3-alpha-mannosidase activity" EXACT [EC:3.2.1.77]
xref: EC:3.2.1.77
xref: MetaCyc:3.2.1.77-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033916
name: beta-agarase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of 1,4-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product." [EC:3.2.1.81]
synonym: "AgaA" RELATED [EC:3.2.1.81]
synonym: "AgaB" RELATED [EC:3.2.1.81]
synonym: "agarase activity" BROAD [EC:3.2.1.81]
synonym: "agarose 3-glycanohydrolase activity" BROAD [EC:3.2.1.81]
synonym: "agarose 4-glycanohydrolase activity" EXACT [EC:3.2.1.81]
xref: EC:3.2.1.81
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033917
name: exo-poly-alpha-galacturonosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of pectic acid from the non-reducing end, releasing digalacturonate." [EC:3.2.1.82]
synonym: "exopolygalacturanosidase activity" EXACT [EC:3.2.1.82]
synonym: "exopolygalacturonosidase activity" EXACT [EC:3.2.1.82]
xref: EC:3.2.1.82
xref: MetaCyc:3.2.1.82-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033918
name: kappa-carrageenase activity
namespace: molecular_function
def: "Catalysis of the reaction: endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans." [EC:3.2.1.83]
synonym: "kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining) activity" EXACT [EC:3.2.1.83]
synonym: "kappa-carrageenan 4-beta-D-glycanohydrolase activity" EXACT [EC:3.2.1.83]
xref: EC:3.2.1.83
xref: MetaCyc:3.2.1.83-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033919
name: glucan 1,3-alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of terminal 1,3-alpha-D-glucosidic links in 1,3-alpha-D-glucans." [EC:3.2.1.84]
synonym: "1,3-alpha-D-glucan 3-glucohydrolase activity" EXACT [EC:3.2.1.84]
synonym: "exo-1,3-alpha-glucanase activity" EXACT [EC:3.2.1.84]
synonym: "glucosidase II activity" EXACT [EC:3.2.1.84]
xref: EC:3.2.1.84
xref: MetaCyc:3.2.1.84-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033920
name: 6-phospho-beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol." [EC:3.2.1.85]
synonym: "6-phospho-beta-D-galactosidase activity" EXACT [EC:3.2.1.85]
synonym: "6-phospho-beta-D-galactoside 6-phosphogalactohydrolase activity" EXACT [EC:3.2.1.85]
synonym: "beta-D-phosphogalactoside galactohydrolase activity" EXACT [EC:3.2.1.85]
synonym: "phospho-beta-D-galactosidase activity" EXACT [EC:3.2.1.85]
synonym: "phospho-beta-galactosidase activity" EXACT [EC:3.2.1.85]
xref: EC:3.2.1.85
xref: MetaCyc:6-PHOSPHO-BETA-GALACTOSIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033921
name: capsular-polysaccharide endo-1,3-alpha-galactosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: random hydrolysis of 1,3-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide." [EC:3.2.1.87]
synonym: "aerobacter-capsular-polysaccharide galactohydrolase activity" EXACT [EC:3.2.1.87]
synonym: "capsular polysaccharide galactohydrolase activity" EXACT [EC:3.2.1.87]
synonym: "polysaccharide depolymerase activity" EXACT [EC:3.2.1.87]
xref: EC:3.2.1.87
xref: MetaCyc:3.2.1.87-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033922
name: peptidoglycan beta-N-acetylmuramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of terminal, non-reducing N-acetylmuramic residues." [EC:3.2.1.92]
synonym: "beta-2-acetamido-3-O-(D-1-carboxyethyl)-2-deoxy-D-glucoside acetamidodeoxyglucohydrolase activity" EXACT [EC:3.2.1.92]
synonym: "exo-beta-acetylmuramidase activity" EXACT [EC:3.2.1.92]
synonym: "exo-beta-N-acetylmuramidase activity" EXACT [EC:3.2.1.92]
synonym: "peptidoglycan beta-N-acetylmuramoylexohydrolase activity" EXACT [EC:3.2.1.92]
xref: EC:3.2.1.92
xref: MetaCyc:3.2.1.92-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033923
name: glucan 1,6-alpha-isomaltosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of 1,6-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains." [EC:3.2.1.94]
synonym: "1,6-alpha-D-glucan isomaltohydrolase activity" EXACT [EC:3.2.1.94]
synonym: "exo-isomaltohydrolase activity" EXACT [EC:3.2.1.94]
synonym: "G2-dextranase activity" EXACT [EC:3.2.1.94]
synonym: "isomalto-dextranase activity" EXACT [EC:3.2.1.94]
synonym: "isomaltodextranase activity" EXACT [EC:3.2.1.94]
xref: EC:3.2.1.94
xref: MetaCyc:3.2.1.94-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033924
name: dextran 1,6-alpha-isomaltotriosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of 1,6-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains." [EC:3.2.1.95]
synonym: "1,6-alpha-D-glucan isomaltotriohydrolase activity" EXACT [EC:3.2.1.95]
synonym: "exo-isomaltotriohydrolase activity" EXACT [EC:3.2.1.95]
xref: EC:3.2.1.95
xref: MetaCyc:3.2.1.95-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033925
name: mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact." [EC:3.2.1.96]
synonym: "di-N-acetylchitobiosyl beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96]
synonym: "endo-beta-(1->4)-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96]
synonym: "endo-beta-acetylglucosaminidase activity" EXACT [EC:3.2.1.96]
synonym: "endo-beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96]
synonym: "endo-beta-N-acetylglucosaminidase D activity" EXACT [EC:3.2.1.96]
synonym: "endo-beta-N-acetylglucosaminidase F activity" EXACT [EC:3.2.1.96]
synonym: "endo-beta-N-acetylglucosaminidase H activity" EXACT [EC:3.2.1.96]
synonym: "endo-beta-N-acetylglucosaminidase L activity" EXACT [EC:3.2.1.96]
synonym: "endo-N-acetyl-beta-D-glucosaminidase activity" EXACT [EC:3.2.1.96]
synonym: "endo-N-acetyl-beta-glucosaminidase activity" EXACT [EC:3.2.1.96]
synonym: "endoglycosidase H activity" EXACT [EC:3.2.1.96]
synonym: "endoglycosidase S activity" EXACT [EC:3.2.1.96]
synonym: "glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" EXACT [EC:3.2.1.96]
synonym: "glycopeptide-D-mannosyl-N4-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" EXACT [EC:3.2.1.96]
synonym: "mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase activity" EXACT [EC:3.2.1.96]
synonym: "mannosyl-glycoprotein endo-beta-N-acetylglucosamidase activity" EXACT [EC:3.2.1.96]
synonym: "N,N'-diacetylchitobiosyl beta-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.96]
xref: EC:3.2.1.96
xref: MetaCyc:3.2.1.96-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033926
name: glycopeptide alpha-N-acetylgalactosaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of terminal D-galactosyl-N-acetyl-alpha-D-galactosaminidic residues from a variety of glycopeptides and glycoproteins." [EC:3.2.1.97]
synonym: "D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase activity" EXACT [EC:3.2.1.97]
synonym: "endo-alpha-acetylgalactosaminidase activity" EXACT [EC:3.2.1.97]
synonym: "endo-alpha-N-acetylgalactosaminidase activity" BROAD [EC:3.2.1.97]
xref: EC:3.2.1.97
xref: MetaCyc:3.2.1.97-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033927
name: glucan 1,4-alpha-maltohexaosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends." [EC:3.2.1.98]
synonym: "1,4-alpha-D-glucan maltohexaohydrolase activity" EXACT [EC:3.2.1.98]
synonym: "exo-maltohexaohydrolase activity" EXACT [EC:3.2.1.98]
synonym: "G6-amylase activity" EXACT [EC:3.2.1.98]
synonym: "maltohexaose-producing amylase activity" EXACT [EC:3.2.1.98]
xref: EC:3.2.1.98
xref: MetaCyc:3.2.1.98-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033928
name: mannan 1,4-mannobiosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of 1,4-beta-D-mannosidic linkages in 1,4-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends." [EC:3.2.1.100]
synonym: "1,4-beta-D-mannan mannobiohydrolase activity" BROAD [EC:3.2.1.100]
synonym: "exo-1,4-beta-mannobiohydrolase activity" EXACT [EC:3.2.1.100]
synonym: "exo-beta-mannanase activity" EXACT [EC:3.2.1.100]
synonym: "mannan 1,4-beta-mannobiosidase activity" EXACT [EC:3.2.1.100]
xref: EC:3.2.1.100
xref: MetaCyc:3.2.1.100-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033929
name: blood-group-substance endo-1,4-beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: endohydrolysis of 1,4-beta-D-galactosidic linkages in blood group A and B substances." [EC:3.2.1.102]
synonym: "blood-group-substance 1,4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.102]
synonym: "endo-beta-galactosidase activity" BROAD [EC:3.2.1.102]
xref: EC:3.2.1.102
xref: MetaCyc:3.2.1.102-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033930
name: keratan-sulfate endo-1,4-beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: endohydrolysis of 1,4-beta-D-galactosidic linkages in keratan sulfate." [EC:3.2.1.103]
synonym: "endo-beta-galactosidase activity" BROAD [EC:3.2.1.103]
synonym: "keratan sulfate endogalactosidase activity" EXACT [EC:3.2.1.103]
synonym: "keratan-sulfate 1,4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.103]
synonym: "keratanase activity" EXACT [EC:3.2.1.103]
xref: EC:3.2.1.103
xref: MetaCyc:3.2.1.103-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033931
name: endogalactosaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: endohydrolysis of 1,4-alpha-D-galactosaminidic linkages in poly(D-galactosamine)." [EC:3.2.1.109]
synonym: "galactosaminoglycan glycanohydrolase activity" EXACT [EC:3.2.1.109]
xref: EC:3.2.1.109
xref: MetaCyc:3.2.1.109-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033932
name: 1,3-alpha-L-fucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of 1,3-linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins." [EC:3.2.1.111]
synonym: "3-alpha-L-fucosyl-N-acetylglucosaminyl-glycoprotein fucohydrolase activity" EXACT [EC:3.2.1.111]
synonym: "almond emulsin fucosidase I activity" EXACT [EC:3.2.1.111]
xref: EC:3.2.1.111
xref: MetaCyc:3.2.1.111-RXN
is_a: GO:0004560 ! alpha-L-fucosidase activity

[Term]
id: GO:0033933
name: branched-dextran exo-1,2-alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of 1,2-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose." [EC:3.2.1.115]
synonym: "1,2-alpha-D-glucosyl-branched-dextran 2-glucohydrolase activity" EXACT [EC:3.2.1.115]
synonym: "dextran 1,2-alpha-glucosidase activity" EXACT [EC:3.2.1.115]
synonym: "dextran alpha-1,2 debranching enzyme" RELATED [EC:3.2.1.115]
xref: EC:3.2.1.115
xref: MetaCyc:3.2.1.115-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033934
name: glucan 1,4-alpha-maltotriohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends." [EC:3.2.1.116]
synonym: "1,4-alpha-D-glucan maltotriohydrolase activity" EXACT [EC:3.2.1.116]
synonym: "exo-maltotriohydrolase activity" EXACT [EC:3.2.1.116]
synonym: "maltotriohydrolase activity" EXACT [EC:3.2.1.116]
xref: EC:3.2.1.116
xref: MetaCyc:3.2.1.116-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033935
name: oligoxyloglucan beta-glycosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of 1,4-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose (i.e. alpha-xylo-1,6-beta-D-glucosyl-) residues from the non-reducing chain ends." [EC:3.2.1.120]
synonym: "isoprimeverose-producing oligoxyloglucan hydrolase activity" EXACT [EC:3.2.1.120]
synonym: "oligoxyloglucan hydrolase activity" EXACT [EC:3.2.1.120]
synonym: "oligoxyloglucan xyloglucohydrolase activity" EXACT [EC:3.2.1.120]
xref: EC:3.2.1.120
xref: MetaCyc:3.2.1.120-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033936
name: polymannuronate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: endohydrolysis of the D-mannuronide linkages of polymannuronate." [EC:3.2.1.121]
synonym: "poly(mannuronide) mannuronohydrolase activity" EXACT [EC:3.2.1.121]
synonym: "polymannuronic acid polymerase activity" EXACT [EC:3.2.1.121]
xref: EC:3.2.1.121
xref: MetaCyc:3.2.1.121-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033937
name: 3-deoxy-2-octulosonidase activity
namespace: molecular_function
def: "Catalysis of the reaction: endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides." [EC:3.2.1.124]
synonym: "2-keto-3-deoxyoctonate hydrolase activity" EXACT [EC:3.2.1.124]
synonym: "capsular-polysaccharide 3-deoxy-D-manno-2-octulosonohydrolase activity" EXACT [EC:3.2.1.124]
synonym: "octulofuranosylono hydrolase activity" EXACT [EC:3.2.1.124]
synonym: "octulopyranosylonohydrolase activity" EXACT [EC:3.2.1.124]
synonym: "octulosylono hydrolase activity" EXACT [EC:3.2.1.124]
xref: EC:3.2.1.124
xref: MetaCyc:3.2.1.124-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033938
name: 1,6-alpha-L-fucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of 1,6-linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin." [EC:3.2.1.127]
synonym: "1,6-L-fucosyl-N-acetyl-D-glucosaminylglycopeptide fucohydrolase activity" EXACT [EC:3.2.1.127]
xref: EC:3.2.1.127
xref: MetaCyc:3.2.1.127-RXN
is_a: GO:0004560 ! alpha-L-fucosidase activity

[Term]
id: GO:0033939
name: xylan alpha-1,2-glucuronosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of alpha-D-1,2-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans." [EC:3.2.1.131]
synonym: "1,2-alpha-glucuronidase activity" EXACT [EC:3.2.1.131]
synonym: "alpha-(1->2)-glucuronidase activity" EXACT [EC:3.2.1.131]
synonym: "xylan alpha-D-1,2-(4-O-methyl)glucuronohydrolase activity" EXACT [EC:3.2.1.131]
xref: EC:3.2.1.131
xref: MetaCyc:3.2.1.131-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033940
name: glucuronoarabinoxylan endo-1,4-beta-xylanase activity
namespace: molecular_function
def: "Catalysis of the reaction: endohydrolysis of 1,4-beta-D-xylosyl links in some glucuronoarabinoxylans." [EC:3.2.1.136]
synonym: "endoarabinoxylanase activity" EXACT [EC:3.2.1.136]
synonym: "feraxan endoxylanase activity" EXACT [EC:3.2.1.136]
synonym: "feraxanase activity" EXACT [EC:3.2.1.136]
synonym: "glucuronoarabinoxylan 1,4-beta-D-xylanohydrolase activity" EXACT [EC:3.2.1.136]
synonym: "glucuronoxylan xylanohydrolase activity" EXACT [EC:3.2.1.136]
synonym: "glucuronoxylan xylohydrolase activity" EXACT [EC:3.2.1.136]
synonym: "glucuronoxylanase activity" EXACT [EC:3.2.1.136]
xref: EC:3.2.1.136
xref: MetaCyc:3.2.1.136-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033941
name: mannan exo-1,2-1,6-alpha-mannosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of 1,2-alpha-D- and 1,6-alpha-D- linkages in yeast mannan, releasing D-mannose." [EC:3.2.1.137]
synonym: "1,2-1,6-alpha-D-mannan D-mannohydrolase activity" EXACT [EC:3.2.1.137]
synonym: "exo-1,2-1,6-alpha-mannosidase activity" EXACT [EC:3.2.1.137]
xref: EC:3.2.1.137
xref: MetaCyc:3.2.1.137-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033942
name: 4-alpha-D-\{(1->4)-alpha-D-glucano}trehalose trehalohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan." [EC:3.2.1.141]
synonym: "4-alpha-D-{(1->4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity" EXACT [EC:3.2.1.141]
synonym: "malto-oligosyltrehalose trehalohydrolase activity" EXACT [EC:3.2.1.141]
synonym: "maltooligosyl trehalose trehalohydrolase activity" EXACT [EC:3.2.1.141]
xref: EC:3.2.1.141
xref: MetaCyc:3.2.1.141-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033943
name: galactan 1,3-beta-galactosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of terminal, non-reducing beta-D-galactose residues in (1->3)-beta-D-galactopyranans." [EC:3.2.1.145]
synonym: "galactan (1->3)-beta-D-galactosidase activity" EXACT [EC:3.2.1.145]
xref: EC:3.2.1.145
xref: MetaCyc:3.2.1.145-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033944
name: beta-galactofuranosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose." [EC:3.2.1.146]
synonym: "beta-D-galactofuranosidase activity" EXACT [EC:3.2.1.146]
synonym: "beta-D-galactofuranoside hydrolase activity" EXACT [EC:3.2.1.146]
synonym: "exo-beta-D-galactofuranosidase activity" EXACT [EC:3.2.1.146]
synonym: "exo-beta-galactofuranosidase activity" EXACT [EC:3.2.1.146]
xref: EC:3.2.1.146
xref: MetaCyc:3.2.1.146-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033945
name: oligoxyloglucan reducing-end-specific cellobiohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a beta-1,4-linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted." [EC:3.2.1.150]
synonym: "oligoxyloglucan reducing end-specific cellobiohydrolase activity" EXACT [EC:3.2.1.150]
synonym: "oligoxyloglucan reducing-end cellobiohydrolase activity" EXACT [EC:3.2.1.150]
xref: EC:3.2.1.150
xref: MetaCyc:3.2.1.150-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033946
name: xyloglucan-specific endo-beta-1,4-glucanase activity
namespace: molecular_function
def: "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides (endohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan)." [EC:3.2.1.151]
synonym: "1,4-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.151]
synonym: "[(1->6)-beta-D-xylo]-(1->4)-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.151]
synonym: "XEG" RELATED [EC:3.2.1.151]
synonym: "XH" RELATED [EC:3.2.1.151]
synonym: "xyloglucan endo-beta-1,4-glucanase activity" EXACT [EC:3.2.1.151]
synonym: "xyloglucanase activity" EXACT [EC:3.2.1.151]
synonym: "xyloglucanendohydrolase activity" EXACT [EC:3.2.1.151]
xref: EC:3.2.1.151
xref: MetaCyc:3.2.1.151-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033947
name: mannosylglycoprotein endo-beta-mannosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequences." [EC:3.2.1.152]
synonym: "endo-beta-mannosidase activity" EXACT [EC:3.2.1.152]
xref: EC:3.2.1.152
xref: MetaCyc:3.2.1.152-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033948
name: fructan beta-(2,1)-fructosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of terminal, non-reducing 2,1-linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.153]
synonym: "1-FEH II" RELATED [EC:3.2.1.153]
synonym: "1-FEH w1" RELATED [EC:3.2.1.153]
synonym: "1-FEH w2" RELATED [EC:3.2.1.153]
synonym: "1-fructan exohydrolase activity" EXACT [EC:3.2.1.153]
synonym: "beta-(2,1)-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.153]
synonym: "beta-(2-1)-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.153]
synonym: "beta-(2-1)-linkage-specific fructan-beta-fructosidase activity" EXACT [EC:3.2.1.153]
synonym: "beta-(2-1)fructan exohydrolase activity" EXACT [EC:3.2.1.153]
xref: EC:3.2.1.153
xref: MetaCyc:3.2.1.153-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033949
name: fructan beta-(2,6)-fructosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of terminal, non-reducing 2,6-linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.154]
synonym: "6-FEH" RELATED [EC:3.2.1.154]
synonym: "beta-(2,6)-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.154]
synonym: "beta-(2-6)-fructan exohydrolase activity" EXACT [EC:3.2.1.154]
xref: EC:3.2.1.154
xref: MetaCyc:3.2.1.154-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033950
name: xyloglucan-specific exo-beta-1,4-glucanase activity
namespace: molecular_function
def: "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides (exohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan)." [EC:3.2.1.155]
synonym: "[(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan exo-glucohydrolase activity" EXACT [EC:3.2.1.155]
synonym: "Cel74A" RELATED [EC:3.2.1.155]
xref: EC:3.2.1.155
xref: MetaCyc:3.2.1.155-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033951
name: oligosaccharide reducing-end xylanase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of 1,4-beta-D-xylose residues from the reducing end of oligosaccharides." [EC:3.2.1.156]
synonym: "beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose reducing-end xylanase activity" EXACT [EC:3.2.1.156]
synonym: "reducing end xylose-releasing exo-oligoxylanase activity" EXACT [EC:3.2.1.156]
synonym: "Rex" RELATED [EC:3.2.1.156]
xref: EC:3.2.1.156
xref: MetaCyc:3.2.1.156-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033952
name: iota-carrageenase activity
namespace: molecular_function
def: "Catalysis of the reaction: endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans." [EC:3.2.1.157]
synonym: "iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting) activity" EXACT [EC:3.2.1.157]
xref: EC:3.2.1.157
xref: MetaCyc:3.2.1.157-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033953
name: alpha-agarase activity
namespace: molecular_function
def: "Catalysis of the reaction: endohydrolysis of 1,3-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product." [EC:3.2.1.158]
synonym: "agarase A33 activity" NARROW [EC:3.2.1.158]
synonym: "agarase activity" BROAD [EC:3.2.1.158]
synonym: "agarose 3-glycanohydrolase activity" BROAD [EC:3.2.1.158]
xref: EC:3.2.1.158
xref: MetaCyc:3.2.1.158-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033954
name: alpha-neoagaro-oligosaccharide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose." [EC:3.2.1.159]
synonym: "alpha-NAOS hydrolase activity" EXACT [EC:3.2.1.159]
synonym: "alpha-neoagaro-oligosaccharide 3-glycohydrolase activity" EXACT [EC:3.2.1.159]
synonym: "alpha-neoagarooligosaccharide hydrolase activity" EXACT [EC:3.2.1.159]
xref: EC:3.2.1.159
xref: MetaCyc:3.2.1.159-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033955
name: mitochondrial DNA inheritance
namespace: biological_process
def: "The process by which copies of the mitochondrial genome are segregated or distributed into daughter mitochondria upon mitochondrial fission." [GOC:mah]
synonym: "mitochondrial chromosome segregation" RELATED []
synonym: "mitochondrial DNA segregation" RELATED []
is_a: GO:0000002 ! mitochondrial genome maintenance
relationship: part_of GO:0000001 ! mitochondrion inheritance

[Term]
id: GO:0033956
name: beta-apiosyl-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose." [EC:3.2.1.161]
synonym: "7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid beta-D-apiofuranosyl-(1->6)-D-glucohydrolase activity" EXACT [EC:3.2.1.161]
synonym: "furcatin hydrolase activity" EXACT [EC:3.2.1.161]
synonym: "isoflavonoid 7-O-beta-apiosyl-glucoside beta-glucosidase activity" EXACT [EC:3.2.1.161]
synonym: "isoflavonoid-7-O-beta[D-apiosyl-(1->6)-beta-D-glucoside] disaccharidase activity" EXACT [EC:3.2.1.161]
xref: EC:3.2.1.161
xref: MetaCyc:3.2.1.161-RXN
xref: MetaCyc:RXN-9156
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033957
name: lambda-carrageenase activity
namespace: molecular_function
def: "Catalysis of the reaction: endohydrolysis of beta-1,4-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Galp2,6S2-(1->3)-beta-D-Galp2S-(1->4)-alpha-D-Galp2,6S2-(1->3)-D-Galp2S." [EC:3.2.1.162]
synonym: "endo-beta-1,4-carrageenose 2,6,2'-trisulfate-hydrolase activity" EXACT [EC:3.2.1.162]
xref: EC:3.2.1.162
xref: MetaCyc:3.2.1.162-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0033958
name: DNA-deoxyinosine glycosylase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolyses DNA and polynucleotides, releasing free hypoxanthine." [EC:3.2.2.15]
synonym: "deoxyribonucleic acid glycosylase activity" EXACT [EC:3.2.2.15]
synonym: "DNA(hypoxanthine) glycohydrolase activity" EXACT [EC:3.2.2.15]
synonym: "DNA-deoxyinosine deoxyribohydrolase activity" EXACT [EC:3.2.2.15]
synonym: "DNA-deoxyinosine glycosidase activity" EXACT [EC:3.2.2.15]
synonym: "hypoxanthine-DNA glycosylase activity" EXACT [EC:3.2.2.15]
xref: EC:3.2.2.15
xref: MetaCyc:3.2.2.15-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0033959
name: deoxyribodipyrimidine endonucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: cleaves the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue." [EC:3.2.2.17]
synonym: "deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase activity" EXACT [EC:3.2.2.17]
synonym: "deoxyribonucleate pyrimidine dimer glycosidase activity" EXACT [EC:3.2.2.17]
synonym: "endonuclease V activity" BROAD [EC:3.2.2.17]
synonym: "PD-DNA glycosylase activity" EXACT [EC:3.2.2.17]
synonym: "pyrimidine dimer DNA glycosylase activity" EXACT [EC:3.2.2.17]
synonym: "pyrimidine dimer DNA-glycosylase activity" EXACT [EC:3.2.2.17]
synonym: "T4-induced UV endonuclease activity" EXACT [EC:3.2.2.17]
xref: EC:3.2.2.17
xref: MetaCyc:3.2.2.17-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0033960
name: N-methyl nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-methylxanthosine + H2O = 7-methylxanthine + D-ribose." [EC:3.2.2.25]
synonym: "7-methylxanthosine nucleosidase activity" EXACT [EC:3.2.2.25]
synonym: "7-methylxanthosine ribohydrolase activity" EXACT [EC:3.2.2.25]
synonym: "methylpurine nucleosidase activity" EXACT [EC:3.2.2.25]
synonym: "N-MeNase activity" EXACT [EC:3.2.2.25]
synonym: "N-methyl nucleoside hydrolase activity" EXACT [EC:3.2.2.25]
xref: EC:3.2.2.25
xref: MetaCyc:RXN-7597
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0033961
name: cis-stilbene-oxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9]
synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.9]
synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.9]
synonym: "benzo(a)pyrene-4,5-epoxide hydratase activity" NARROW [EC:3.3.2.9]
synonym: "benzo[a]pyrene-4,5-oxide hydratase activity" NARROW [EC:3.3.2.9]
synonym: "cis-epoxide hydrolase activity" EXACT [EC:3.3.2.9]
synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.9]
synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.9]
synonym: "mEH" RELATED [EC:3.3.2.9]
synonym: "microsomal epoxide hydrase activity" NARROW [EC:3.3.2.9]
synonym: "microsomal epoxide hydratase activity" NARROW [EC:3.3.2.9]
synonym: "microsomal epoxide hydrolase activity" NARROW [EC:3.3.2.9]
xref: EC:3.3.2.9
xref: MetaCyc:3.3.2.9-RXN
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0033962
name: cytoplasmic mRNA processing body assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074]
synonym: "P body assembly" EXACT []
synonym: "P body biogenesis" RELATED []
synonym: "P-body assembly" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly

[Term]
id: GO:0033963
name: cholesterol-5,6-oxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol and 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol." [EC:3.3.2.11]
synonym: "5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase activity" EXACT [EC:3.3.2.11]
synonym: "ChEH" RELATED [EC:3.3.2.11]
synonym: "cholesterol-epoxide hydrolase activity" EXACT [EC:3.3.2.11]
xref: EC:3.3.2.11
xref: MetaCyc:RXN-8650
xref: MetaCyc:RXN-8651
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0033964
name: glycosphingolipid deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives." [EC:3.5.1.69]
synonym: "glycosphingolipid amidohydrolase activity" EXACT [EC:3.5.1.69]
synonym: "glycosphingolipid ceramide deacylase activity" BROAD [EC:3.5.1.69]
xref: EC:3.5.1.69
xref: MetaCyc:3.5.1.69-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033965
name: aculeacin-A deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain." [EC:3.5.1.70]
synonym: "aculeacin A acylase activity" EXACT [EC:3.5.1.70]
synonym: "aculeacin-A amidohydrolase activity" EXACT [EC:3.5.1.70]
xref: EC:3.5.1.70
xref: MetaCyc:3.5.1.70-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033966
name: N-substituted formamide deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine." [EC:3.5.1.91]
synonym: "N-benzylformamide amidohydrolase activity" EXACT [EC:3.5.1.91]
synonym: "NfdA" RELATED [EC:3.5.1.91]
xref: MetaCyc:3.5.1.91-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033967
name: box C/D snoRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving box C/D type small nucleolar RNA." [GOC:mah]
is_a: GO:0016074 ! snoRNA metabolic process

[Term]
id: GO:0033968
name: glutaryl-7-aminocephalosporanic-acid acylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate." [EC:3.5.1.93]
synonym: "(7R)-7-(4-carboxybutanamido)cephalosporanate amidohydrolase activity" EXACT [EC:3.5.1.93]
synonym: "7beta-(4-carboxybutanamido)cephalosporanic acid acylase activity" EXACT [EC:3.5.1.93]
synonym: "CA" RELATED [EC:3.5.1.93]
synonym: "cephalosporin acylase activity" EXACT [EC:3.5.1.93]
synonym: "cephalosporin C acylase activity" EXACT [EC:3.5.1.93]
synonym: "GA" RELATED [EC:3.5.1.93]
synonym: "GCA" RELATED [EC:3.5.1.93]
synonym: "GL-7-ACA acylase activity" EXACT [EC:3.5.1.93]
synonym: "glutaryl-7-ACA acylase activity" EXACT [EC:3.5.1.93]
synonym: "glutaryl-7-aminocephalosporanic acid acylase activity" EXACT [EC:3.5.1.93]
xref: EC:3.5.1.93
xref: MetaCyc:3.5.1.93-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033969
name: gamma-glutamyl-gamma-aminobutyrate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate." [EC:3.5.1.94]
synonym: "4-(glutamylamino)butanoate amidohydrolase activity" EXACT [EC:3.5.1.94]
synonym: "gamma-glutamyl-GABA hydrolase activity" EXACT [EC:3.5.1.94]
synonym: "PuuD" RELATED [EC:3.5.1.94]
synonym: "YcjL" RELATED [EC:3.5.1.94]
xref: EC:3.5.1.94
xref: MetaCyc:RXN0-3942
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033970
name: N-malonylurea hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxo-3-ureidopropanoate + H2O = malonate + urea." [EC:3.5.1.95]
synonym: "3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming) activity" EXACT [EC:3.5.1.95]
synonym: "ureidomalonase activity" EXACT [EC:3.5.1.95]
xref: EC:3.5.1.95
xref: MetaCyc:3.5.1.95-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0033971
name: hydroxyisourate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate." [EC:3.5.2.17]
synonym: "5-hydroxyisourate amidohydrolase activity" EXACT [EC:3.5.2.17]
synonym: "5-hydroxyisourate hydrolase activity" EXACT [EC:3.5.2.17]
synonym: "HIUHase activity" EXACT [EC:3.5.2.17]
xref: EC:3.5.2.17
xref: MetaCyc:3.5.2.17-RXN
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0033972
name: proclavaminate amidinohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: amidinoproclavaminate + H2O = proclavaminate + urea." [EC:3.5.3.22]
synonym: "PAH" RELATED [EC:3.5.3.22]
synonym: "proclavaminate amidino hydrolase activity" EXACT [EC:3.5.3.22]
synonym: "proclavaminic acid amidino hydrolase activity" EXACT [EC:3.5.3.22]
xref: EC:3.5.3.22
xref: MetaCyc:3.5.3.22-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0033973
name: dCTP deaminase (dUMP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: dCTP + 2 H2O = dUMP + diphosphate + NH3." [EC:3.5.4.30]
synonym: "dCTP aminohydrolase (dUMP-forming) activity" EXACT [EC:3.5.4.30]
xref: EC:3.5.4.30
xref: MetaCyc:3.5.4.30-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0033974
name: nucleoside phosphoacylhydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolyses mixed phospho-anhydride bonds." [EC:3.6.1.24]
synonym: "nucleoside-5'-phosphoacylate acylhydrolase activity" EXACT [EC:3.6.1.24]
xref: EC:3.6.1.24
xref: MetaCyc:3.6.1.24-RXN
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0033975
name: (R)-2-haloacid dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide." [EC:3.8.1.9]
synonym: "(R)-2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.9]
synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.9]
synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.9]
synonym: "D-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.9]
synonym: "D-DEX" RELATED [EC:3.8.1.9]
xref: EC:3.8.1.9
xref: MetaCyc:3.8.1.9-RXN
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0033976
name: 2-haloacid dehalogenase (configuration-inverting) activity
namespace: molecular_function
def: "Catalysis of the reactions: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide and (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide." [EC:3.8.1.10]
synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.10]
synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.10]
synonym: "DL-2-haloacid dehalogenase (inversion of configuration) activity" EXACT [EC:3.8.1.10]
synonym: "DL-2-haloacid dehalogenase activity" BROAD [EC:3.8.1.10]
synonym: "DL-2-haloacid halidohydrolase (inversion of configuration) activity" EXACT [EC:3.8.1.10]
synonym: "DL-DEXi" RELATED [EC:3.8.1.10]
xref: EC:3.8.1.10
xref: MetaCyc:3.8.1.10-RXN
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0033977
name: 2-haloacid dehalogenase (configuration-retaining) activity
namespace: molecular_function
def: "Catalysis of the reactions: (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide and (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [EC:3.8.1.11]
synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.11]
synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.11]
synonym: "DL-2-haloacid dehalogenase activity" BROAD [EC:3.8.1.11]
synonym: "DL-DEXr" RELATED [EC:3.8.1.11]
xref: EC:3.8.1.11
xref: MetaCyc:3.8.1.11-RXN
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0033978
name: phosphonopyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phosphonopyruvate + H2O = pyruvate + phosphate." [EC:3.11.1.3]
synonym: "PPH" RELATED [EC:3.11.1.3]
xref: EC:3.11.1.3
xref: MetaCyc:3.11.1.3-RXN
is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds

[Term]
id: GO:0033979
name: box H/ACA snoRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving box H/ACA type small nucleolar RNA." [GOC:mah]
is_a: GO:0016074 ! snoRNA metabolic process

[Term]
id: GO:0033980
name: phosphonopyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phosphonopyruvate = 2-phosphonoacetaldehyde + CO2." [EC:4.1.1.82]
synonym: "3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming) activity" EXACT [EC:4.1.1.82]
synonym: "3-phosphonopyruvate carboxy-lyase activity" EXACT [EC:4.1.1.82]
xref: EC:4.1.1.82
xref: MetaCyc:4.1.1.82-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0033981
name: D-dopachrome decarboxylase activity
namespace: molecular_function
alt_id: GO:0030928
def: "Catalysis of the reaction: D-dopachrome = 5,6-dihydroxyindole + CO2." [EC:4.1.1.84]
synonym: "D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming) activity" EXACT [EC:4.1.1.84]
synonym: "D-dopachrome carboxy-lyase activity" EXACT [EC:4.1.1.84]
synonym: "D-dopachrome tautomerase activity" EXACT [EC:4.1.1.84]
synonym: "D-tautomerase activity" EXACT [EC:4.1.1.84]
synonym: "dopachrome conversion activity" BROAD []
synonym: "dopachrome decarboxylase activity" EXACT []
synonym: "phenylpyruvate tautomerase II activity" EXACT [EC:4.1.1.84]
xref: EC:4.1.1.84
xref: MetaCyc:4.1.1.84-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0033982
name: 3-dehydro-L-gulonate-6-phosphate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H+ = L-xylulose 5-phosphate + CO2." [EC:4.1.1.85]
synonym: "3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming) activity" EXACT [EC:4.1.1.85]
synonym: "3-dehydro-L-gulonate-6-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.85]
synonym: "3-keto-L-gulonate 6-phosphate decarboxylase activity" EXACT [EC:4.1.1.85]
synonym: "KGPDC" RELATED [EC:4.1.1.85]
synonym: "SgaH" RELATED [EC:4.1.1.85]
synonym: "SgbH" RELATED [EC:4.1.1.85]
synonym: "UlaD" RELATED [EC:4.1.1.85]
xref: EC:4.1.1.85
xref: MetaCyc:RXN0-705
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0033983
name: diaminobutyrate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2,4-diaminobutanoate = propane-1,3-diamine + CO2." [EC:4.1.1.86]
synonym: "DABA DC" RELATED [EC:4.1.1.86]
synonym: "L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming) activity" EXACT [EC:4.1.1.86]
synonym: "L-2,4-diaminobutanoate carboxy-lyase activity" EXACT [EC:4.1.1.86]
synonym: "L-2,4-diaminobutyrate decarboxylase activity" EXACT [EC:4.1.1.86]
xref: EC:4.1.1.86
xref: MetaCyc:4.1.1.86-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0033984
name: indole-3-glycerol-phosphate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate." [EC:4.1.2.8]
synonym: "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming) activity" EXACT [EC:4.1.2.8]
synonym: "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.8]
synonym: "BX1" RELATED [EC:4.1.2.8]
synonym: "IGL" RELATED [EC:4.1.2.8]
synonym: "indole glycerol phosphate hydrolase activity" EXACT [EC:4.1.2.8]
synonym: "indole synthase activity" EXACT [EC:4.1.2.8]
synonym: "indole-3-glycerol phosphate lyase activity" EXACT [EC:4.1.2.8]
synonym: "indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.8]
synonym: "indoleglycerolphosphate aldolase activity" EXACT [EC:4.1.2.8]
synonym: "tryptophan synthase alpha activity" EXACT [EC:4.1.2.8]
synonym: "TSA" RELATED [EC:4.1.2.8]
xref: EC:4.1.2.8
xref: MetaCyc:4.1.2.8-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0033985
name: acidocalcisome lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of an acidocalcisome." [GOC:mah]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0020022 ! acidocalcisome

[Term]
id: GO:0033986
name: response to methanol
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:sl]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0033987
name: 2-hydroxyisoflavanone dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,7,4'-trihydroxyisoflavanone = daidzein + H2O." [EC:4.2.1.105]
synonym: "2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming) activity" EXACT [EC:4.2.1.105]
synonym: "2,7,4'-trihydroxyisoflavanone hydro-lyase activity" EXACT [EC:4.2.1.105]
xref: EC:4.2.1.105
xref: MetaCyc:RXN-3284
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033988
name: bile-acid 7alpha-dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate = 12alpha-hydroxy-3-oxochola-4,6-dienoate + H2O." [EC:4.2.1.106]
synonym: "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming) activity" EXACT [EC:4.2.1.106]
synonym: "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase activity" EXACT [EC:4.2.1.106]
synonym: "BA7 alpha dehydratase activity" EXACT [EC:4.2.1.106]
xref: EC:4.2.1.106
xref: MetaCyc:4.2.1.106-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033989
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O." [EC:4.2.1.107]
synonym: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming] activity" EXACT [EC:4.2.1.107]
synonym: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.107]
synonym: "46 kDa hydratase 2 activity" EXACT [EC:4.2.1.107]
synonym: "D-3-hydroxyacyl-CoA dehydratase activity" BROAD [EC:4.2.1.107]
xref: EC:4.2.1.107
xref: MetaCyc:4.2.1.107-RXN
xref: Reactome:261000 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity"
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033990
name: ectoine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: N4-acetyl-L-2,4-diaminobutanoate = L-ectoine + H2O." [EC:4.2.1.108]
synonym: "4-N-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity" EXACT [EC:4.2.1.108]
synonym: "EctC" RELATED [EC:4.2.1.108]
synonym: "L-ectoine synthase activity" EXACT [EC:4.2.1.108]
synonym: "N-acetyldiaminobutanoate dehydratase activity" EXACT [EC:4.2.1.108]
synonym: "N-acetyldiaminobutyrate dehydratase activity" EXACT [EC:4.2.1.108]
synonym: "N4-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity" EXACT [EC:4.2.1.108]
xref: EC:4.2.1.108
xref: MetaCyc:4.2.1.108-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033991
name: aldos-2-ulose dehydratase activity
namespace: molecular_function
def: "Catalysis of the reactions: 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O (overall reaction), (1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O and (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one." [EC:4.2.1.110]
synonym: "1,5-anhydro-D-fructose dehydratase (microthecin-forming) activity" EXACT [EC:4.2.1.110]
synonym: "1,5-anhydro-D-fructose hydro-lyase (microthecin-forming) activity" EXACT [EC:4.2.1.110]
synonym: "AUDH" RELATED [EC:4.2.1.110]
synonym: "pyranosone dehydratase activity" EXACT [EC:4.2.1.110]
xref: EC:4.2.1.110
xref: MetaCyc:4.2.1.110-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033992
name: 1,5-anhydro-D-fructose dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O." [EC:4.2.1.111]
synonym: "1,5-anhydro-D-arabino-hex-2-ulose dehydratase activity" EXACT [EC:4.2.1.111]
synonym: "1,5-anhydro-D-fructose 4-dehydratase activity" EXACT [EC:4.2.1.111]
synonym: "1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming) activity" EXACT [EC:4.2.1.111]
synonym: "1,5-anhydro-D-fructose hydro-lyase activity" EXACT [EC:4.2.1.111]
synonym: "1,5-anhydro-D-fructose hydrolyase activity" EXACT [EC:4.2.1.111]
synonym: "AF dehydratase activity" EXACT [EC:4.2.1.111]
synonym: "AFDH" RELATED [EC:4.2.1.111]
xref: EC:4.2.1.111
xref: MetaCyc:4.2.1.111-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0033993
name: response to lipid
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0033994
name: glucuronan lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: Eliminative cleavage of (1->4)-beta-D-glucuronans to give oligosaccharides with 4-deoxy-beta-D-gluc-4-enuronosyl groups at their non-reducing ends. Complete degradation of glucuronans results in the formation of tetrasaccharides." [EC:4.2.2.14]
synonym: "(1,4)-beta-D-glucuronan lyase activity" EXACT [EC:4.2.2.14]
xref: EC:4.2.2.14
xref: MetaCyc:4.2.2.14-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0033995
name: anhydrosialidase activity
namespace: molecular_function
def: "Catalysis of the reaction: Elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate." [EC:4.2.2.15]
synonym: "anhydroneuraminidase activity" EXACT [EC:4.2.2.15]
synonym: "glycoconjugate sialyl-lyase (2,7-cyclizing) activity" EXACT [EC:4.2.2.15]
synonym: "sialglycoconjugate N-acylneuraminylhydrolase (2,7-cyclizing) activity" EXACT [EC:4.2.2.15]
synonym: "sialidase L activity" EXACT [EC:4.2.2.15]
xref: EC:4.2.2.15
xref: MetaCyc:4.2.2.15-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0033996
name: levan fructotransferase (DFA-IV-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: Produces di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.16]
synonym: "2,6-beta-D-fructan D-fructosyl-D-fructosyltransferase (forming di-beta-D-fructofuranose 2,6':2',6-dianhydride) activity" EXACT [EC:4.2.2.16]
synonym: "2,6-beta-D-fructan lyase (di-beta-D-fructofuranose-2,6':2',6-dianhydride-forming) activity" EXACT [EC:4.2.2.16]
synonym: "levan fructotransferase activity" EXACT [EC:4.2.2.16]
xref: EC:4.2.2.16
xref: MetaCyc:4.2.2.16-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0033997
name: inulin fructotransferase (DFA-I-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: Produces alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,1'-dianhydride (DFA I) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.17]
synonym: "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,1'-dianhydride-forming) activity" EXACT [EC:4.2.2.17]
synonym: "inulin D-fructosyl-D-fructosyltransferase (1,2':1',2-dianhydride-forming) activity" EXACT [EC:4.2.2.17]
synonym: "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':1',2-dianhydride) activity" EXACT [EC:4.2.2.17]
synonym: "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2',1-dianhydride-forming) activity" EXACT [EC:4.2.2.17]
synonym: "inulin fructotransferase (DFA-I-producing) activity" EXACT [EC:4.2.2.17]
xref: EC:4.2.2.17
xref: MetaCyc:4.2.2.17-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0033998
name: inulin fructotransferase (DFA-III-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: Produces alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride (DFA III) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.18]
synonym: "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18]
synonym: "inulase II activity" EXACT [EC:4.2.2.18]
synonym: "inulin D-fructosyl-D-fructosyltransferase (1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18]
synonym: "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride) activity" EXACT [EC:4.2.2.18]
synonym: "inulin fructotransferase (depolymerizing) activity" EXACT [EC:4.2.2.18]
synonym: "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2,3'-dianhydride-forming) activity" EXACT [EC:4.2.2.18]
synonym: "inulin fructotransferase (DFA-III-producing) activity" EXACT [EC:4.2.2.18]
synonym: "inulinase II activity" EXACT [EC:4.2.2.18]
xref: EC:4.2.2.18
xref: MetaCyc:4.2.2.18-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0033999
name: chondroitin B lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: Eliminative cleavage of dermatan sulfate containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucurosonyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (DeltaUA-GalNAC-4S)." [EC:4.2.2.19]
synonym: "ChnB" RELATED [EC:4.2.2.19]
synonym: "chonB" RELATED [EC:4.2.2.19]
synonym: "chondroitinase B activity" EXACT [EC:4.2.2.19]
xref: EC:4.2.2.19
xref: MetaCyc:4.2.2.19-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0034000
name: chondroitin-sulfate-ABC endolyase activity
namespace: molecular_function
def: "Catalysis of the reaction: Endolytic cleavage of beta-1,4-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta4-unsaturated tetra- and disaccharides." [EC:4.2.2.20]
synonym: "chondroitin ABC eliminase activity" BROAD [EC:4.2.2.20]
synonym: "chondroitin sulfate ABC endoeliminase activity" EXACT [EC:4.2.2.20]
synonym: "chondroitin sulfate ABC endolyase activity" EXACT [EC:4.2.2.20]
synonym: "chondroitin sulfate ABC lyase activity" BROAD [EC:4.2.2.20]
synonym: "chondroitinase ABC activity" BROAD [EC:4.2.2.20]
synonym: "chondroitinase activity" BROAD [EC:4.2.2.20]
synonym: "ChS ABC lyase activity" BROAD [EC:4.2.2.20]
synonym: "ChS ABC lyase I activity" EXACT [EC:4.2.2.20]
xref: EC:4.2.2.20
xref: MetaCyc:4.2.2.20-RXN
is_a: GO:0047486 ! chondroitin ABC lyase activity

[Term]
id: GO:0034001
name: chondroitin-sulfate-ABC exolyase activity
namespace: molecular_function
def: "Catalysis of the reaction: Exolytic cleavage of disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments." [EC:4.2.2.21]
synonym: "chondroitin ABC eliminase activity" BROAD [EC:4.2.2.21]
synonym: "chondroitin sulfate ABC exoeliminase activity" EXACT [EC:4.2.2.21]
synonym: "chondroitin sulfate ABC exolyase activity" EXACT [EC:4.2.2.21]
synonym: "chondroitin sulfate ABC lyase activity" BROAD [EC:4.2.2.21]
synonym: "chondroitinase ABC activity" BROAD [EC:4.2.2.21]
synonym: "chondroitinase activity" BROAD [EC:4.2.2.21]
synonym: "ChS ABC lyase activity" BROAD [EC:4.2.2.21]
synonym: "ChS ABC lyase II activity" EXACT [EC:4.2.2.21]
xref: EC:4.2.2.21
xref: MetaCyc:4.2.2.21-RXN
is_a: GO:0047486 ! chondroitin ABC lyase activity

[Term]
id: GO:0034002
name: (R)-limonene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = (+)-(4R)-limonene + diphosphate." [EC:4.2.3.20]
synonym: "(+)-limonene synthase activity" EXACT [EC:4.2.3.20]
synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming] activity" EXACT [EC:4.2.3.20]
synonym: "geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming] activity" EXACT [EC:4.2.3.20]
xref: EC:4.2.3.20
xref: MetaCyc:4.2.3.20-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034003
name: vetispiradiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = vetispiradiene + diphosphate." [EC:4.2.3.21]
synonym: "HVS" RELATED [EC:4.2.3.21]
synonym: "pemnaspirodiene synthase activity" EXACT [EC:4.2.3.21]
synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming) activity" EXACT [EC:4.2.3.21]
synonym: "vetispiradiene cyclase activity" EXACT [EC:4.2.3.21]
synonym: "vetispiradiene-forming farnesyl pyrophosphate cyclase activity" EXACT [EC:4.2.3.21]
xref: EC:4.2.3.21
xref: MetaCyc:RXN-4823
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034004
name: germacradienol synthase activity
namespace: molecular_function
def: "Catalysis of the reactions: 2-trans,6-trans-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate and 2-trans,6-trans-farnesyl diphosphate = (-)-(7S)-germacrene D + diphosphate." [EC:4.2.3.22]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming] activity" EXACT [EC:4.2.3.22]
synonym: "germacradienol/germacrene-D synthase activity" EXACT [EC:4.2.3.22]
xref: EC:4.2.3.22
xref: MetaCyc:RXN-8562
xref: MetaCyc:RXN-8648
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034005
name: germacrene-A synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate." [EC:4.2.3.23]
synonym: "(+)-(10R)-germacrene A synthase activity" EXACT [EC:4.2.3.23]
synonym: "(+)-germacrene A synthase activity" EXACT [EC:4.2.3.23]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming) activity" EXACT [EC:4.2.3.23]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-A-forming] activity" EXACT [EC:4.2.3.23]
synonym: "GAS" RELATED [EC:4.2.3.23]
synonym: "germacrene A synthase activity" EXACT [EC:4.2.3.23]
xref: EC:4.2.3.23
xref: MetaCyc:4.2.3.23-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034006
name: amorpha-4,11-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = amorpha-4,11-diene + diphosphate." [EC:4.2.3.24]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming) activity" EXACT [EC:4.2.3.24]
synonym: "amorphadiene synthase activity" EXACT [EC:4.2.3.24]
xref: EC:4.2.3.24
xref: MetaCyc:4.2.3.24-RXN
xref: MetaCyc:RXN-8046
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034007
name: S-linalool synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + H2O = (3S)-linalool + diphosphate." [EC:4.2.3.25]
synonym: "3S-linalool synthase activity" EXACT [EC:4.2.3.25]
synonym: "geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming] activity" EXACT [EC:4.2.3.25]
synonym: "LIS" RELATED [EC:4.2.3.25]
synonym: "Lis" RELATED [EC:4.2.3.25]
xref: EC:4.2.3.25
xref: MetaCyc:4.2.3.25-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034008
name: R-linalool synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate + H2O = (3R)-linalool + diphosphate." [EC:4.2.3.26]
synonym: "(-)-3R-linalool synthase activity" EXACT [EC:4.2.3.26]
synonym: "(3R)-linalool synthase activity" EXACT [EC:4.2.3.26]
synonym: "geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming] activity" EXACT [EC:4.2.3.26]
xref: EC:4.2.3.26
xref: MetaCyc:4.2.3.26-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034009
name: isoprene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylallyl diphosphate = isoprene + diphosphate." [EC:4.2.3.27]
synonym: "dimethylallyl-diphosphate diphosphate-lyase (isoprene-forming) activity" EXACT [EC:4.2.3.27]
synonym: "ISPC" RELATED [EC:4.2.3.27]
synonym: "ISPS" RELATED [EC:4.2.3.27]
xref: EC:4.2.3.27
xref: MetaCyc:4.2.3.27-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034010
name: sulfolactate sulfo-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-sulfolactate = pyruvate + bisulfite." [EC:4.4.1.24]
synonym: "3-sulfolactate bisulfite-lyase (pyruvate-forming) activity" EXACT [EC:4.4.1.24]
synonym: "3-sulfolactate bisulfite-lyase activity" EXACT [EC:4.4.1.24]
synonym: "Suy" RELATED [EC:4.4.1.24]
synonym: "SuyAB" RELATED [EC:4.4.1.24]
xref: EC:4.4.1.24
xref: MetaCyc:4.4.1.24-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0034011
name: L-cysteate sulfo-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteate + H2O = pyruvate + bisulfite + NH3." [EC:4.4.1.25]
synonym: "CuyA" RELATED [EC:4.4.1.25]
synonym: "L-cysteate bisulfite-lyase (deaminating; pyruvate-forming) activity" EXACT [EC:4.4.1.25]
synonym: "L-cysteate sulfo-lyase (deaminating) activity" EXACT [EC:4.4.1.25]
xref: EC:4.4.1.25
xref: MetaCyc:4.4.1.25-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0034012
name: FAD-AMP lyase (cyclizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: FAD = AMP + riboflavin cyclic-4',5'-phosphate." [EC:4.6.1.15]
synonym: "FAD AMP-lyase (cyclic-FMN-forming) activity" EXACT [EC:4.6.1.15]
synonym: "FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) activity" EXACT [EC:4.6.1.15]
synonym: "FMN cyclase activity" EXACT [EC:4.6.1.15]
xref: EC:4.6.1.15
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0034013
name: aliphatic aldoxime dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O." [EC:4.99.1.5]
synonym: "aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming) activity" EXACT [EC:4.99.1.5]
synonym: "aliphatic aldoxime hydro-lyase activity" EXACT [EC:4.99.1.5]
synonym: "OxdA" RELATED [EC:4.99.1.5]
xref: EC:4.99.1.5
xref: MetaCyc:4.99.1.5-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0034014
name: response to triglyceride
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus." [GOC:sl]
synonym: "response to triacylglyceride" EXACT []
synonym: "response to triacylglycerol" EXACT []
is_a: GO:0033993 ! response to lipid

[Term]
id: GO:0034015
name: L-ribulose-5-phosphate 3-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate." [EC:5.1.3.22]
synonym: "L-xylulose 5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.22]
synonym: "SgaU" RELATED [EC:5.1.3.22]
synonym: "UlaE" RELATED [EC:5.1.3.22]
xref: EC:5.1.3.22
xref: MetaCyc:LXULRU5P-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0034016
name: polyenoic fatty acid isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate = (5Z,7E,8E,14Z,17Z)-eicosapentaenoate." [EC:5.3.3.13]
synonym: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,8-isomerase activity" EXACT [EC:5.3.3.13]
synonym: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity" EXACT [EC:5.3.3.13]
synonym: "(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity" EXACT [EC:5.3.3.13]
synonym: "eicosapentaenoate cis-delta5,8,11,14,17-eicosapentaenoate cis-delta5-trans-delta7,9-cis-delta14,17 isomerase activity" EXACT [EC:5.3.3.13]
synonym: "PFI" RELATED [EC:5.3.3.13]
xref: EC:5.3.3.13
xref: MetaCyc:5.3.3.13-RXN
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0034017
name: trans-2-decenoyl-acyl-carrier-protein isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-dec-2-enoyl-acyl-carrier-protein = cis-dec-3-enoyl-acyl-carrier-protein." [EC:5.3.3.14]
synonym: "beta-hydroxydecanoyl thioester dehydrase activity" BROAD [EC:5.3.3.14]
synonym: "decenoyl-acyl-carrier-protein delta2-trans-delta3-cis-isomerase activity" EXACT [EC:5.3.3.14]
synonym: "FabM" RELATED [EC:5.3.3.14]
synonym: "trans-2,cis-3-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14]
synonym: "trans-2-cis-3-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14]
synonym: "trans-2-decenoyl-ACP isomerase activity" EXACT [EC:5.3.3.14]
xref: EC:5.3.3.14
xref: MetaCyc:5.3.3.14-RXN
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0034018
name: ascopyrone tautomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose." [EC:5.3.3.15]
synonym: "1,5-anhydro-D-glycero-hex-3-en-2-ulose delta3-delta1-isomerase activity" EXACT [EC:5.3.3.15]
synonym: "1,5-anhydro-D-glycero-hex-3-en-2-ulose tautomerase activity" EXACT [EC:5.3.3.15]
synonym: "APM tautomerase activity" EXACT [EC:5.3.3.15]
synonym: "APTM" RELATED [EC:5.3.3.15]
synonym: "ascopyrone intramolecular oxidoreductase activity" EXACT [EC:5.3.3.15]
synonym: "ascopyrone isomerase activity" EXACT [EC:5.3.3.15]
synonym: "ascopyrone P tautomerase activity" EXACT [EC:5.3.3.15]
xref: EC:5.3.3.15
xref: MetaCyc:5.3.3.15-RXN
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0034019
name: capsanthin/capsorubin synthase activity
namespace: molecular_function
def: "Catalysis of the reactions: violaxanthin = capsorubin and antheraxanthin = capsanthin." [EC:5.3.99.8]
synonym: "capsanthin-capsorubin synthase activity" EXACT [EC:5.3.99.8]
synonym: "CCS" RELATED [EC:5.3.99.8]
synonym: "ketoxanthophyll synthase activity" EXACT [EC:5.3.99.8]
synonym: "violaxanthin-capsorubin isomerase (ketone-forming) activity" EXACT [EC:5.3.99.8]
xref: EC:5.3.99.8
xref: MetaCyc:RXN-7946
xref: MetaCyc:RXN-7947
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0034020
name: neoxanthin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: violaxanthin = neoxanthin." [EC:5.3.99.9]
synonym: "NSY" RELATED [EC:5.3.99.9]
synonym: "violaxanthin-neoxanthin isomerase (epoxide-opening) activity" EXACT [EC:5.3.99.9]
xref: EC:5.3.99.9
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0034021
name: response to silicon dioxide
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus." [GOC:sl]
synonym: "response to silica" EXACT []
synonym: "response to silox" EXACT []
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0034022
name: 3-(hydroxyamino)phenol mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxyaminophenol = aminohydroquinone." [EC:5.4.4.3]
synonym: "3-(hydroxyamino)phenol hydroxymutase activity" EXACT [EC:5.4.4.3]
synonym: "3-hydroxylaminophenol mutase activity" EXACT [EC:5.4.4.3]
synonym: "3HAP mutase activity" EXACT [EC:5.4.4.3]
xref: EC:5.4.4.3
xref: MetaCyc:5.4.4.3-RXN
xref: UM-BBD_enzymeID:e0953
is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups

[Term]
id: GO:0034023
name: 5-(carboxyamino)imidazole ribonucleotide mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate." [EC:5.4.99.18]
synonym: "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase activity" EXACT [EC:5.4.99.18]
synonym: "class I PurE" RELATED [EC:5.4.99.18]
synonym: "N5-CAIR mutase activity" EXACT [EC:5.4.99.18]
synonym: "N5-carboxyaminoimidazole ribonucleotide mutase activity" EXACT [EC:5.4.99.18]
synonym: "PurE" RELATED [EC:5.4.99.18]
xref: EC:5.4.99.18
xref: MetaCyc:5.4.99.18-RXN
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0034024
name: glutamate-putrescine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-glutamate + putrescine = ADP + phosphate + gamma-L-glutamylputrescine." [EC:6.3.1.11]
synonym: "gamma-glutamylputrescine synthetase activity" EXACT [EC:6.3.1.11]
synonym: "L-glutamate:putrescine ligase (ADP-forming) activity" EXACT [EC:6.3.1.11]
synonym: "YcjK" RELATED [EC:6.3.1.11]
xref: EC:6.3.1.11
xref: MetaCyc:RXN0-3901
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0034025
name: D-aspartate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate." [EC:6.3.1.12]
synonym: "aslfm" RELATED [EC:6.3.1.12]
synonym: "D-aspartate:[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n ligase (ADP-forming) activity" EXACT [EC:6.3.1.12]
synonym: "D-aspartic acid-activating enzyme" RELATED [EC:6.3.1.12]
synonym: "UDP-MurNAc-pentapeptide:D-aspartate ligase activity" EXACT [EC:6.3.1.12]
xref: EC:6.3.1.12
xref: MetaCyc:6.3.1.12-RXN
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0034026
name: L-amino-acid alpha-ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + an L-amino acid + an L-amino acid = ADP + phosphate + L-aminoacyl-L-amino acid." [EC:6.3.2.28]
synonym: "bacilysin synthetase activity" EXACT [EC:6.3.2.28]
synonym: "L-amino acid alpha-ligase activity" EXACT [EC:6.3.2.28]
synonym: "L-amino acid ligase activity" EXACT [EC:6.3.2.28]
synonym: "YwfE" RELATED [EC:6.3.2.28]
xref: EC:6.3.2.28
xref: MetaCyc:6.3.2.28-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0034027
name: (carboxyethyl)arginine beta-lactam-synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-N2-(2-carboxyethyl)arginine = AMP + diphosphate + deoxyamidinoproclavaminate." [EC:6.3.3.4]
synonym: "beta-lactam synthetase activity" EXACT [EC:6.3.3.4]
synonym: "L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity" EXACT [EC:6.3.3.4]
synonym: "L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity" EXACT [EC:6.3.3.4]
xref: EC:6.3.3.4
xref: MetaCyc:6.3.3.4-RXN
is_a: GO:0016882 ! cyclo-ligase activity

[Term]
id: GO:0034028
name: 5-(carboxyamino)imidazole ribonucleotide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole." [EC:6.3.4.18]
synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.18]
synonym: "N5-CAIR synthetase activity" EXACT [EC:6.3.4.18]
synonym: "N5-carboxyaminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.4.18]
synonym: "PurK" RELATED [EC:6.3.4.18]
xref: EC:6.3.4.18
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0034029
name: 2-oxoglutarate carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2-oxoglutarate + HCO3- = ADP + phosphate + oxalosuccinate." [EC:6.4.1.7]
synonym: "carboxylating factor for ICDH" RELATED [EC:6.4.1.7]
synonym: "CFI" RELATED [EC:6.4.1.7]
synonym: "OGC" RELATED [EC:6.4.1.7]
synonym: "oxalosuccinate synthetase activity" EXACT [EC:6.4.1.7]
xref: EC:6.4.1.7
is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds

[Term]
id: GO:0034030
name: ribonucleoside bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd]
subset: gosubset_prok
synonym: "ribonucleoside bisphosphate anabolism" EXACT []
synonym: "ribonucleoside bisphosphate biosynthesis" EXACT []
synonym: "ribonucleoside bisphosphate formation" EXACT []
synonym: "ribonucleoside bisphosphate synthesis" EXACT []
is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process
is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process

[Term]
id: GO:0034031
name: ribonucleoside bisphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside bisphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd]
subset: gosubset_prok
synonym: "ribonucleoside bisphosphate breakdown" EXACT []
synonym: "ribonucleoside bisphosphate catabolism" EXACT []
synonym: "ribonucleoside bisphosphate degradation" EXACT []
is_a: GO:0033869 ! nucleoside bisphosphate catabolic process
is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process

[Term]
id: GO:0034032
name: purine nucleoside bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a purine nucleoside bisphosphate, a glycosamine consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd]
subset: gosubset_prok
synonym: "purine nucleoside bisphosphate metabolism" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0033865 ! nucleoside bisphosphate metabolic process

[Term]
id: GO:0034033
name: purine nucleoside bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a glycosamine consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd]
subset: gosubset_prok
synonym: "purine nucleoside bisphosphate anabolism" EXACT []
synonym: "purine nucleoside bisphosphate biosynthesis" EXACT []
synonym: "purine nucleoside bisphosphate formation" EXACT []
synonym: "purine nucleoside bisphosphate synthesis" EXACT []
is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process
is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process

[Term]
id: GO:0034034
name: purine nucleoside bisphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleoside bisphosphate, a glycosamine consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd]
subset: gosubset_prok
synonym: "purine nucleoside bisphosphate breakdown" EXACT []
synonym: "purine nucleoside bisphosphate catabolism" EXACT []
synonym: "purine nucleoside bisphosphate degradation" EXACT []
is_a: GO:0033869 ! nucleoside bisphosphate catabolic process
is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process

[Term]
id: GO:0034035
name: purine ribonucleoside bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd]
subset: gosubset_prok
synonym: "purine ribonucleoside bisphosphate metabolism" EXACT []
is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process
is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process

[Term]
id: GO:0034036
name: purine ribonucleoside bisphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleoside bisphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd]
subset: gosubset_prok
synonym: "purine ribonucleoside bisphosphate anabolism" EXACT []
synonym: "purine ribonucleoside bisphosphate biosynthesis" EXACT []
synonym: "purine ribonucleoside bisphosphate formation" EXACT []
synonym: "purine ribonucleoside bisphosphate synthesis" EXACT []
is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process
is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process
is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process

[Term]
id: GO:0034037
name: purine ribonucleoside bisphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleoside bisphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on its glycose moiety." [GOC:mah, GOC:pd]
subset: gosubset_prok
synonym: "purine ribonucleoside bisphosphate breakdown" EXACT []
synonym: "purine ribonucleoside bisphosphate catabolism" EXACT []
synonym: "purine ribonucleoside bisphosphate degradation" EXACT []
is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process
is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process
is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process

[Term]
id: GO:0034038
name: deoxyhypusine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+." [EC:2.5.1.46, GOC:pd, MetaCyc:2.5.1.46-RXN]
comment: Note that this term is equivalent to the obsolete molecular function term 'deoxyhypusine synthase activity ; GO:0004171' and corresponds closely to the biological process term 'spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase ; GO:0050983'.
synonym: "eIF-5A-deoxyhypusine synthase activity" EXACT [EC:2.5.1.46]
synonym: "eIF5A-precursor-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity" EXACT [EC:2.5.1.46]
synonym: "spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity" EXACT [EC:2.5.1.46]
xref: EC:2.5.1.46
xref: MetaCyc:2.5.1.46-RXN
xref: Reactome:210313 "deoxyhypusine synthase activity"
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0034039
name: 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar." [GOC:mah, PMID:17641464]
synonym: "8-oxoG DNA N-glycosylase activity" EXACT []
is_a: GO:0008534 ! oxidized purine base lesion DNA N-glycosylase activity

[Term]
id: GO:0034040
name: lipid-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out)." [GOC:BHF, GOC:rl]
is_a: GO:0005319 ! lipid transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0034041
name: sterol-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out)." [GOC:BHF, GOC:rl]
is_a: GO:0015248 ! sterol transporter activity
is_a: GO:0034040 ! lipid-transporting ATPase activity

[Term]
id: GO:0034042
name: 5-formyluracil DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of 5-formyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:mah, PMID:17641464]
synonym: "5-foU DNA N-glycosylase activity" EXACT []
is_a: GO:0000703 ! oxidized pyrimidine base lesion DNA N-glycosylase activity

[Term]
id: GO:0034043
name: 5-hydroxymethyluracil DNA N-glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:mah, PMID:17641464]
synonym: "5-hmU DNA N-glycosylase activity" EXACT []
is_a: GO:0000703 ! oxidized pyrimidine base lesion DNA N-glycosylase activity

[Term]
id: GO:0034044
name: exomer complex
namespace: cellular_component
def: "A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues." [PMID:16498409, PMID:17000877]
is_a: GO:0043234 ! protein complex
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle

[Term]
id: GO:0034045
name: pre-autophagosomal structure membrane
namespace: cellular_component
def: "A cellular membrane associated with the pre-autophagosomal structure." [GOC:mah, GOC:rph, PMID:16874040, PMID:17382324]
synonym: "isolation membrane" RELATED []
synonym: "PAS membrane" EXACT []
is_a: GO:0016020 ! membrane
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0000407 ! pre-autophagosomal structure

[Term]
id: GO:0034046
name: poly(G) RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a sequence of guanine residues in an RNA molecule." [GOC:mah]
synonym: "poly(G) binding" BROAD []
synonym: "poly(rG) binding" EXACT [GOC:mah]
is_a: GO:0070717 ! poly-purine tract binding

[Term]
id: GO:0034047
name: regulation of protein phosphatase type 2A activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme protein phosphatase type 2A." [GOC:mah]
is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity

[Term]
id: GO:0034048
name: negative regulation of protein phosphatase type 2A activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme protein phosphatase type 2A." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of protein phosphatase type 2A activity" EXACT []
synonym: "down-regulation of protein phosphatase type 2A activity" EXACT []
synonym: "downregulation of protein phosphatase type 2A activity" EXACT []
synonym: "inhibition of protein phosphatase type 2A activity" NARROW []
is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity
is_a: GO:0034047 ! regulation of protein phosphatase type 2A activity

[Term]
id: GO:0034049
name: positive regulation of protein phosphatase type 2A activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme protein phosphatase type 2A." [GOC:mah]
subset: gosubset_prok
synonym: "activation of protein phosphatase type 2A activity" NARROW []
synonym: "stimulation of protein phosphatase type 2A activity" NARROW []
synonym: "up regulation of protein phosphatase type 2A activity" EXACT []
synonym: "up-regulation of protein phosphatase type 2A activity" EXACT []
synonym: "upregulation of protein phosphatase type 2A activity" EXACT []
is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity
is_a: GO:0034047 ! regulation of protein phosphatase type 2A activity

[Term]
id: GO:0034050
name: host programmed cell death induced by symbiont
namespace: biological_process
def: "Cell death in a host resulting from activation of host endogenous cellular processes after direct or indirect interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). An example of direct interaction is contact with penetrating hyphae of a fungus; an example of indirect interaction is encountering symbiont-secreted molecules." [GOC:pamgo_curators]
comment: Note that this term is to be used to annotate gene products in the host, not the symbiont. To annotate gene products in the symbiont that induce programmed cell death in the host, consider the biological process term 'induction by symbiont of host programmed cell death ; GO:0052044'.
is_a: GO:0012501 ! programmed cell death

[Term]
id: GO:0034051
name: negative regulation of plant-type hypersensitive response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the hypersensitive response in a plant." [GOC:pamgo_curators]
synonym: "down regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "down-regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "downregulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "inhibition of plant-type hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "negative regulation of HR" EXACT [GOC:pamgo_curators]
synonym: "negative regulation of HR-PCD" EXACT [GOC:pamgo_curators]
synonym: "negative regulation of plant hypersensitive response" EXACT [GOC:pamgo_curators]
is_a: GO:0010363 ! regulation of plant-type hypersensitive response
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:0045824 ! negative regulation of innate immune response
relationship: negatively_regulates GO:0009626 ! plant-type hypersensitive response

[Term]
id: GO:0034052
name: positive regulation of plant-type hypersensitive response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the hypersensitive response in a plant." [GOC:pamgo_curators]
synonym: "activation of plant-type hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "positive regulation of HR" EXACT [GOC:pamgo_curators]
synonym: "positive regulation of HR-PCD" RELATED [GOC:pamgo_curators]
synonym: "positive regulation of plant hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "stimulation of plant-type hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "up regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "up-regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
synonym: "upregulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators]
is_a: GO:0010363 ! regulation of plant-type hypersensitive response
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:0045089 ! positive regulation of innate immune response
relationship: positively_regulates GO:0009626 ! plant-type hypersensitive response

[Term]
id: GO:0034053
name: modulation by symbiont of host defense-related programmed cell death
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'plant-type hypersensitive response ; GO:0009626'.
synonym: "modulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators]
synonym: "modulation by symbiont of host HR" NARROW [GOC:pamgo_curators]
synonym: "modulation by symbiont of host hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "modulation by symbiont of plant HR" NARROW [GOC:pamgo_curators]
synonym: "modulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators]
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052040 ! modulation by symbiont of host programmed cell death

[Term]
id: GO:0034054
name: negative regulation by symbiont of host defense-related programmed cell death
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of plant-type hypersensitive response ; GO:0034051'.
synonym: "down regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
synonym: "down-regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
synonym: "downregulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
synonym: "inhibition by symbiont of host defense-related PCD" NARROW [GOC:pamgo_curators]
synonym: "inhibition by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators]
synonym: "inhibition of host defense-related PCD" NARROW [GOC:pamgo_curators]
synonym: "inhibition of HR" NARROW [GOC:pamgo_curators]
synonym: "inhibition of hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "negative regulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators]
synonym: "negative regulation by symbiont of plant HR" NARROW [GOC:pamgo_curators]
synonym: "negative regulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "suppression by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators]
synonym: "suppression of HR" NARROW [GOC:pamgo_curators]
is_a: GO:0034053 ! modulation by symbiont of host defense-related programmed cell death
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052041 ! negative regulation by symbiont of host programmed cell death

[Term]
id: GO:0034055
name: positive regulation by symbiont of host defense-related programmed cell death
namespace: biological_process
def: "Any process by which an organism activates or increases the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'positive regulation of plant-type hypersensitive response ; GO:0034052'.
synonym: "activation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators]
synonym: "activation of HR" NARROW [GOC:pamgo_curators]
synonym: "activation of hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "enhancement by symbiont of host defense-related PCDprogrammed cell death" NARROW [GOC:pamgo_curators]
synonym: "positive regulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators]
synonym: "positive regulation by symbiont of plant HR" NARROW [GOC:pamgo_curators]
synonym: "positive regulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators]
synonym: "stimulation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators]
synonym: "up regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
synonym: "up-regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
synonym: "upregulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators]
is_a: GO:0034053 ! modulation by symbiont of host defense-related programmed cell death
is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death
is_a: GO:0052509 ! positive regulation by symbiont of host defense response

[Term]
id: GO:0034056
name: estrogen response element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen." [GOC:ecd, PMID:15036253, PMID:17975005]
synonym: "ERE binding" EXACT []
is_a: GO:0010843 ! promoter binding

[Term]
id: GO:0034057
name: RNA strand-exchange activity
namespace: molecular_function
def: "Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity." [GOC:mcc, PMID:9769100]
is_a: GO:0003725 ! double-stranded RNA binding
is_a: GO:0003727 ! single-stranded RNA binding

[Term]
id: GO:0034058
name: endosomal vesicle fusion
namespace: biological_process
def: "The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733]
synonym: "endosome vesicle fusion" EXACT []
is_a: GO:0006906 ! vesicle fusion

[Term]
id: GO:0034059
name: response to anoxia
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:kmv]
comment: Note that this term should not be confused with 'response to hypoxia ; GO:0001666'.
synonym: "response to anoxic stress" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0070482 ! response to oxygen levels

[Term]
id: GO:0034060
name: cyanelle stroma
namespace: cellular_component
def: "The space enclosed by the double membrane of a cyanelle." [GOC:rph]
is_a: GO:0009532 ! plastid stroma
relationship: part_of GO:0009842 ! cyanelle

[Term]
id: GO:0034061
name: DNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and primer." [EC:2.7.7.7, GOC:mah]
subset: gosubset_prok
synonym: "deoxynucleate polymerase activity" EXACT [EC:2.7.7.7]
synonym: "deoxyribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.7]
synonym: "deoxyribonucleic acid polymerase activity" EXACT [EC:2.7.7.7]
synonym: "deoxyribonucleic polymerase activity" EXACT [EC:2.7.7.7]
synonym: "DNA nucleotidyltransferase activity" EXACT [EC:2.7.7.7]
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0034062
name: RNA polymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template." [EC:2.7.7.6, GOC:mah]
subset: gosubset_prok
synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6]
synonym: "C RNA formation factors" RELATED [EC:2.7.7.6]
synonym: "ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6]
synonym: "ribonucleate polymerase activity" EXACT [EC:2.7.7.6]
synonym: "ribonucleic acid nucleotidyltransferase" BROAD [EC:2.7.7.6]
synonym: "ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6]
synonym: "ribonucleic acid transcriptase activity" EXACT [EC:2.7.7.6]
synonym: "ribonucleic polymerase activity" EXACT [EC:2.7.7.6]
synonym: "ribonucleic transcriptase activity" EXACT [EC:2.7.7.6]
synonym: "RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6]
synonym: "RNA transcriptase activity" EXACT [EC:2.7.7.6]
synonym: "transcriptase" BROAD [EC:2.7.7.6]
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0034063
name: stress granule assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519]
is_a: GO:0022618 ! ribonucleoprotein complex assembly

[Term]
id: GO:0034064
name: Tor2-Mei2-Ste11 complex
namespace: cellular_component
def: "A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast." [GOC:vw, PMID:17046992]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0034065
name: replication fork processing at rDNA locus
namespace: biological_process
def: "The process by which a DNA replication fork that has stalled at the rDNA replication fork barrier (RFB) is repaired and replication is restarted." [GOC:vw]
synonym: "recovery from replication fork arrest at rDNA locus" EXACT []
synonym: "recovery from replication fork stalling at rDNA locus" EXACT []
synonym: "replication fork processing at ribosomal DNA locus" EXACT []
is_a: GO:0031297 ! replication fork processing
is_a: GO:0043007 ! maintenance of rDNA

[Term]
id: GO:0034066
name: Ric1p-Rgp1p complex
namespace: cellular_component
def: "A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi." [GOC:jh, GOC:mah, PMID:10990452]
is_a: GO:0043234 ! protein complex
is_a: GO:0044431 ! Golgi apparatus part

[Term]
id: GO:0034067
name: protein localization in Golgi apparatus
namespace: biological_process
def: "A process by which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah]
synonym: "protein localization to Golgi apparatus" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization in organelle

[Term]
id: GO:0034068
name: aminoglycoside nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction nucleoside triphosphate + aminoglycoside = diphosphate + nucleotidylaminoglycoside." [GOC:cb]
subset: gosubset_prok
synonym: "aminoglycoside adenylyltransferase activity" NARROW []
synonym: "streptomycin adenylate synthetase activity" NARROW [EC:2.7.7.47]
synonym: "streptomycin adenyltransferase activity" NARROW [EC:2.7.7.47]
synonym: "streptomycin adenylylase activity" NARROW [EC:2.7.7.47]
synonym: "streptomycin adenylyltransferase activity" NARROW [EC:2.7.7.47]
synonym: "streptomycin-spectinomycin adenylyltransferase activity" NARROW [EC:2.7.7.47]
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0034069
name: aminoglycoside N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + N-acetylaminoglycoside." [GOC:cb]
subset: gosubset_prok
synonym: "kanamycin acetyltransferase activity" NARROW []
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0034070
name: aminoglycoside 1-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring." [GOC:cb]
is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity

[Term]
id: GO:0034071
name: aminoglycoside phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + aminoglycoside = ADP + phosphoaminoglycoside." [GOC:cb, GOC:mah]
subset: gosubset_prok
synonym: "aminoglycoside kinase activity" EXACT []
xref: EC:2.7.1.119
xref: MetaCyc:HYGROMYCIN-B-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0034072
name: squalene cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: squalene = triterpene." [GOC:cb, PMID:18033581]
is_a: GO:0009975 ! cyclase activity

[Term]
id: GO:0034073
name: tetrahymanol cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: squalene = tetrahymanol." [ChEBI:9493, GOC:cb, PMID:18033581]
is_a: GO:0034072 ! squalene cyclase activity

[Term]
id: GO:0034074
name: marneral synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidosqualene = marneral." [GOC:cb, http://www.wiley-vch.de/contents/jc_2002/2006/z503420_s.pdf, PMID:16425307, PMID:18033581]
xref: MetaCyc:RXN-9664
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0034075
name: arabidiol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidosqualene + H2O= arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol)." [GOC:cb, PMID:16774269, PMID:17474751]
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0034076
name: cucurbitadienol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidosqualene = cucurbitadienol." [GOC:cb, PMID:18033581]
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0034077
name: butanediol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [ISBN:0911910123, MetaCyc:BUTANEDIOL, MetaCyc:P125-PWY]
subset: gosubset_prok
synonym: "butanediol metabolism" EXACT []
synonym: "butylene glycol metabolic process" EXACT []
synonym: "butylene glycol metabolism" EXACT []
is_a: GO:0034311 ! diol metabolic process

[Term]
id: GO:0034078
name: butanediol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL]
subset: gosubset_prok
synonym: "butanediol breakdown" EXACT []
synonym: "butanediol catabolism" EXACT []
synonym: "butanediol degradation" EXACT []
synonym: "butanediol utilization" RELATED []
synonym: "butylene glycol catabolic process" EXACT []
synonym: "butylene glycol catabolism" EXACT []
is_a: GO:0034077 ! butanediol metabolic process
is_a: GO:0034313 ! diol catabolic process

[Term]
id: GO:0034079
name: butanediol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL]
subset: gosubset_prok
synonym: "butanediol anabolism" EXACT []
synonym: "butanediol biosynthesis" EXACT []
synonym: "butanediol formation" EXACT []
synonym: "butanediol synthesis" EXACT []
synonym: "butylene glycol biosynthesis" EXACT []
synonym: "butylene glycol biosynthetic process" EXACT []
xref: MetaCyc:P125-PWY
is_a: GO:0034077 ! butanediol metabolic process
is_a: GO:0034312 ! diol biosynthetic process

[Term]
id: GO:0034080
name: CenH3-containing nucleosome assembly at centromere
namespace: biological_process
def: "The formation of nucleosomes containing the histone H3 variant CenH3 (also called CENP-A) to form centromeric chromatin; occurs outside the context of DNA replication." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403]
synonym: "centromere specific nucleosome exchange" RELATED [GOC:mah]
synonym: "centromere-specific histone exchange" EXACT [GOC:mah, GOC:vw]
synonym: "centromere-specific nucleosome assembly" EXACT [GOC:vw]
synonym: "centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:mah]
synonym: "DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:mah]
is_a: GO:0006336 ! DNA replication-independent nucleosome assembly
is_a: GO:0031055 ! chromatin remodeling at centromere
is_a: GO:0043486 ! histone exchange

[Term]
id: GO:0034081
name: polyketide synthase complex
namespace: cellular_component
def: "A protein complex that carries out enzymatic reactions involved in the biosynthesis of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones." [GOC:mah, PMID:12636085]
synonym: "PKS" RELATED []
synonym: "PKS complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034082
name: type II polyketide synthase complex
namespace: cellular_component
def: "A polyketide synthase complex that consists of several different polypeptide chains, each of which catalyzes a single reaction." [GOC:cb, GOC:mah, PMID:12636085]
synonym: "type II PKS" EXACT []
synonym: "type II PKS complex" EXACT []
synonym: "type II polyketide synthase" EXACT []
is_a: GO:0034081 ! polyketide synthase complex

[Term]
id: GO:0034083
name: type III polyketide synthase complex
namespace: cellular_component
def: "A polyketide synthase complex that consists of two identical ketosynthase polypeptides." [GOC:cb, PMID:12636085]
synonym: "type III PKS" EXACT []
synonym: "type III PKS complex" EXACT []
synonym: "type III polyketide synthase" EXACT []
is_a: GO:0034081 ! polyketide synthase complex

[Term]
id: GO:0034084
name: steryl deacetylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol." [GOC:rb, PMID:18034159]
synonym: "sterol deacetylase activity" EXACT []
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0034085
name: establishment of sister chromatid cohesion
namespace: biological_process
def: "The process by which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase." [GOC:mah, PMID:14623866]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0034086
name: maintenance of sister chromatid cohesion
namespace: biological_process
def: "The process by which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate." [GOC:mah, PMID:14623866]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0034087
name: establishment of mitotic sister chromatid cohesion
namespace: biological_process
def: "The process by which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle." [GOC:mah]
is_a: GO:0034085 ! establishment of sister chromatid cohesion
relationship: part_of GO:0007064 ! mitotic sister chromatid cohesion

[Term]
id: GO:0034088
name: maintenance of mitotic sister chromatid cohesion
namespace: biological_process
def: "The process by which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah]
synonym: "mitotic cohesion stability" RELATED []
is_a: GO:0034086 ! maintenance of sister chromatid cohesion
relationship: part_of GO:0007064 ! mitotic sister chromatid cohesion

[Term]
id: GO:0034089
name: establishment of meiotic sister chromatid cohesion
namespace: biological_process
def: "The process by which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a meiotic cell cycle." [GOC:mah]
is_a: GO:0034085 ! establishment of sister chromatid cohesion
relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion

[Term]
id: GO:0034090
name: maintenance of meiotic sister chromatid cohesion
namespace: biological_process
def: "The process by which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:mah]
is_a: GO:0034086 ! maintenance of sister chromatid cohesion
relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion

[Term]
id: GO:0034091
name: regulation of maintenance of sister chromatid cohesion
namespace: biological_process
def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw]
is_a: GO:0007063 ! regulation of sister chromatid cohesion
relationship: regulates GO:0034086 ! maintenance of sister chromatid cohesion

[Term]
id: GO:0034092
name: negative regulation of maintenance of sister chromatid cohesion
namespace: biological_process
def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw]
is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion
is_a: GO:0045875 ! negative regulation of sister chromatid cohesion
relationship: negatively_regulates GO:0034086 ! maintenance of sister chromatid cohesion

[Term]
id: GO:0034093
name: positive regulation of maintenance of sister chromatid cohesion
namespace: biological_process
def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw]
is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion
is_a: GO:0045876 ! positive regulation of sister chromatid cohesion
relationship: positively_regulates GO:0034086 ! maintenance of sister chromatid cohesion

[Term]
id: GO:0034094
name: regulation of maintenance of meiotic sister chromatid cohesion
namespace: biological_process
def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion
is_a: GO:0040020 ! regulation of meiosis
relationship: regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion

[Term]
id: GO:0034095
name: negative regulation of maintenance of meiotic sister chromatid cohesion
namespace: biological_process
def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0034092 ! negative regulation of maintenance of sister chromatid cohesion
is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion
relationship: negatively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion

[Term]
id: GO:0034096
name: positive regulation of maintenance of meiotic sister chromatid cohesion
namespace: biological_process
def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0034093 ! positive regulation of maintenance of sister chromatid cohesion
is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion
relationship: positively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion

[Term]
id: GO:0034097
name: response to cytokine stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0034098
name: Cdc48p-Npl4p-Ufd1p AAA ATPase complex
namespace: cellular_component
def: "A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins." [PMID:11813000, PMID:16179952]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0034099
name: luminal surveillance complex
namespace: cellular_component
def: "A multiprotein complex that recognizes ERAD-luminal misfolded substrates and brings them to the ubiquitination/extraction machinery. In yeast, this complex consists of Yos9p, Kar2p and Hrd3p proteins." [PMID:16873065]
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005788 ! endoplasmic reticulum lumen

[Term]
id: GO:0034101
name: erythrocyte homeostasis
namespace: biological_process
def: "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397]
synonym: "RBC homeostasis" EXACT [CL:0000232]
synonym: "red blood cell homeostasis" EXACT [CL:0000232]
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0034102
name: erythrocyte clearance
namespace: biological_process
def: "The selective elimination of erythrocytes from the body by autoregulatory mechanisms." [GOC:add, PMID:12905029, PMID:14754397]
comment: Note that this term is intended for annotation of self-gene products that lead to elimination of erythrocytes without the involvement of a symbiont.
synonym: "neocytolysis" NARROW [PMID:14754397]
synonym: "RBC clearance" EXACT [CL:0000232]
synonym: "red blood cell clearance" EXACT [CL:0000232]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0034101 ! erythrocyte homeostasis

[Term]
id: GO:0034103
name: regulation of tissue remodeling
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of tissue remodeling." [GOC:add]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0048771 ! tissue remodeling

[Term]
id: GO:0034104
name: negative regulation of tissue remodeling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate, or extent of tissue remodeling." [GOC:add]
is_a: GO:0034103 ! regulation of tissue remodeling
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0048771 ! tissue remodeling

[Term]
id: GO:0034105
name: positive regulation of tissue remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of tissue remodeling." [GOC:add]
is_a: GO:0034103 ! regulation of tissue remodeling
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0048771 ! tissue remodeling

[Term]
id: GO:0034106
name: regulation of erythrocyte clearance
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397]
synonym: "regulation of neocytolysis" NARROW [PMID:14754397]
synonym: "regulation of RBC clearance" EXACT [CL:0000232]
synonym: "regulation of red blood cell clearance" EXACT [CL:0000232]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0034103 ! regulation of tissue remodeling
relationship: regulates GO:0034102 ! erythrocyte clearance

[Term]
id: GO:0034107
name: negative regulation of erythrocyte clearance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397]
synonym: "negative regulation of neocytolysis" NARROW [PMID:14754397]
synonym: "negative regulation of RBC clearance" EXACT [CL:0000232]
synonym: "negative regulation of red blood cell clearance" EXACT [CL:0000232]
is_a: GO:0034104 ! negative regulation of tissue remodeling
is_a: GO:0034106 ! regulation of erythrocyte clearance
relationship: negatively_regulates GO:0034102 ! erythrocyte clearance

[Term]
id: GO:0034108
name: positive regulation of erythrocyte clearance
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397]
synonym: "positive regulation of neocytolysis" NARROW [PMID:14754397]
synonym: "positive regulation of RBC clearance" EXACT [CL:0000232]
synonym: "positive regulation of red blood cell clearance" EXACT [CL:0000232]
is_a: GO:0034105 ! positive regulation of tissue remodeling
is_a: GO:0034106 ! regulation of erythrocyte clearance
relationship: positively_regulates GO:0034102 ! erythrocyte clearance

[Term]
id: GO:0034109
name: homotypic cell-cell adhesion
namespace: biological_process
def: "The attachment of a cell to a second cell of the identical type via adhesion molecules." [GOC:add]
comment: Note that this term is not synonymous with 'homophilic cell adhesion ; GO:0007156'; the process may occur by homophilic or heterophilic mechanisms.
is_a: GO:0016337 ! cell-cell adhesion

[Term]
id: GO:0034110
name: regulation of homotypic cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: regulates GO:0034109 ! homotypic cell-cell adhesion

[Term]
id: GO:0034111
name: negative regulation of homotypic cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion
relationship: negatively_regulates GO:0034109 ! homotypic cell-cell adhesion

[Term]
id: GO:0034112
name: positive regulation of homotypic cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion
relationship: positively_regulates GO:0034109 ! homotypic cell-cell adhesion

[Term]
id: GO:0034113
name: heterotypic cell-cell adhesion
namespace: biological_process
def: "The attachment of a cell to a cell of a different type via adhesion molecules." [GOC:add]
comment: Note that this term is not synonymous with 'heterophilic cell adhesion ; GO:0007157'; the process may occur by homophilic or heterophilic mechanisms.
is_a: GO:0016337 ! cell-cell adhesion

[Term]
id: GO:0034114
name: regulation of heterotypic cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: regulates GO:0034113 ! heterotypic cell-cell adhesion

[Term]
id: GO:0034115
name: negative regulation of heterotypic cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0034114 ! regulation of heterotypic cell-cell adhesion
is_a: GO:0070587 ! regulation of cell-cell adhesion involved in gastrulation
relationship: negatively_regulates GO:0034113 ! heterotypic cell-cell adhesion

[Term]
id: GO:0034116
name: positive regulation of heterotypic cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add]
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0034114 ! regulation of heterotypic cell-cell adhesion
is_a: GO:0070587 ! regulation of cell-cell adhesion involved in gastrulation
relationship: positively_regulates GO:0034113 ! heterotypic cell-cell adhesion

[Term]
id: GO:0034117
name: erythrocyte aggregation
namespace: biological_process
def: "The adhesion of one erythrocyte to one or more other erythrocytes via adhesion molecules." [GOC:add, PMID:14631543]
synonym: "RBC aggregation" EXACT [CL:0000232]
synonym: "red blood cell aggregation" EXACT [CL:0000232]
is_a: GO:0034109 ! homotypic cell-cell adhesion

[Term]
id: GO:0034118
name: regulation of erythrocyte aggregation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of erythrocyte aggregation." [GOC:add]
synonym: "regulation of RBC aggregation" EXACT [CL:0000232]
synonym: "regulation of red blood cell aggregation" EXACT [CL:0000232]
is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion
relationship: regulates GO:0034117 ! erythrocyte aggregation

[Term]
id: GO:0034119
name: negative regulation of erythrocyte aggregation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate, or extent of erythrocyte aggregation." [GOC:add]
synonym: "negative regulation of RBC aggregation" EXACT [CL:0000232]
synonym: "negative regulation of red blood cell aggregation" EXACT [CL:0000232]
is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion
is_a: GO:0034118 ! regulation of erythrocyte aggregation
relationship: negatively_regulates GO:0034117 ! erythrocyte aggregation

[Term]
id: GO:0034120
name: positive regulation of erythrocyte aggregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of erythrocyte aggregation." [GOC:add]
synonym: "positive regulation of RBC aggregation" EXACT [CL:0000232]
synonym: "positive regulation of red blood cell aggregation" EXACT [CL:0000232]
is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion
is_a: GO:0034118 ! regulation of erythrocyte aggregation
relationship: positively_regulates GO:0034117 ! erythrocyte aggregation

[Term]
id: GO:0034121
name: regulation of toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR signaling pathway" EXACT []
synonym: "regulation of toll-like receptor signalling pathway" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034122
name: negative regulation of toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor signalling pathway" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: negatively_regulates GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034123
name: positive regulation of toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor signalling pathway" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: positively_regulates GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034124
name: regulation of MyD88-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation ofMyD88-dependent TLR signaling pathway" EXACT []
synonym: "regulation ofMyD88-dependent toll-like receptor signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway

[Term]
id: GO:0034125
name: negative regulation of MyD88-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of MyD88-dependent TLR signaling pathway" EXACT []
synonym: "negative regulation of MyD88-dependent toll-like receptor signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034124 ! regulation of MyD88-dependent toll-like receptor signaling pathway
relationship: negatively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway

[Term]
id: GO:0034126
name: positive regulation of MyD88-dependent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of MyD88-dependent TLR signaling pathway" EXACT []
synonym: "positive regulation of MyD88-dependent toll-like receptor signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034124 ! regulation of MyD88-dependent toll-like receptor signaling pathway
relationship: positively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway

[Term]
id: GO:0034127
name: regulation of MyD88-independent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation ofMyD88-independent TLR signaling pathway" EXACT []
synonym: "regulation ofMyD88-independent toll-like receptor signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway

[Term]
id: GO:0034128
name: negative regulation of MyD88-independent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of MyD88-independent TLR signaling pathway" EXACT []
synonym: "negative regulation of MyD88-independent toll-like receptor signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034127 ! regulation of MyD88-independent toll-like receptor signaling pathway
relationship: negatively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway

[Term]
id: GO:0034129
name: positive regulation of MyD88-independent toll-like receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of MyD88-independent TLR signaling pathway" EXACT []
synonym: "positive regulation of MyD88-independent toll-like receptor" EXACT []
synonym: "positive regulation of MyD88-independent toll-like receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034127 ! regulation of MyD88-independent toll-like receptor signaling pathway
relationship: positively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway

[Term]
id: GO:0034130
name: toll-like receptor 1 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 1." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR1 signaling pathway" EXACT []
synonym: "toll-like receptor 1 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034131
name: regulation of toll-like receptor 1 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR1 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 1 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0034130 ! toll-like receptor 1 signaling pathway

[Term]
id: GO:0034132
name: negative regulation of toll-like receptor 1 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR1 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 1 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034131 ! regulation of toll-like receptor 1 signaling pathway
relationship: negatively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway

[Term]
id: GO:0034133
name: positive regulation of toll-like receptor 1 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR1 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 1 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034131 ! regulation of toll-like receptor 1 signaling pathway
relationship: positively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway

[Term]
id: GO:0034134
name: toll-like receptor 2 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 2." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR2 signaling pathway" EXACT []
synonym: "toll-like receptor 2 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034135
name: regulation of toll-like receptor 2 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR2 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 2 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0034134 ! toll-like receptor 2 signaling pathway

[Term]
id: GO:0034136
name: negative regulation of toll-like receptor 2 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR2 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 2 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034135 ! regulation of toll-like receptor 2 signaling pathway
relationship: negatively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway

[Term]
id: GO:0034137
name: positive regulation of toll-like receptor 2 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR2 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 2 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034135 ! regulation of toll-like receptor 2 signaling pathway
relationship: positively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway

[Term]
id: GO:0034138
name: toll-like receptor 3 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 3." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR3 signaling pathway" EXACT []
synonym: "toll-like receptor 3 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034139
name: regulation of toll-like receptor 3 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR3 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 3 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0034138 ! toll-like receptor 3 signaling pathway

[Term]
id: GO:0034140
name: negative regulation of toll-like receptor 3 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR3 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 3 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034139 ! regulation of toll-like receptor 3 signaling pathway
relationship: negatively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway

[Term]
id: GO:0034141
name: positive regulation of toll-like receptor 3 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR3 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 3 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034139 ! regulation of toll-like receptor 3 signaling pathway
relationship: positively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway

[Term]
id: GO:0034142
name: toll-like receptor 4 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 4." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR4 signaling pathway" EXACT []
synonym: "toll-like receptor 4 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034143
name: regulation of toll-like receptor 4 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR4 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 4 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0034142 ! toll-like receptor 4 signaling pathway

[Term]
id: GO:0034144
name: negative regulation of toll-like receptor 4 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR4 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 4 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034143 ! regulation of toll-like receptor 4 signaling pathway
relationship: negatively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway

[Term]
id: GO:0034145
name: positive regulation of toll-like receptor 4 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR4 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 4 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034143 ! regulation of toll-like receptor 4 signaling pathway
relationship: positively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway

[Term]
id: GO:0034146
name: toll-like receptor 5 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 5." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR5 signaling pathway" EXACT []
synonym: "toll-like receptor 5 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034147
name: regulation of toll-like receptor 5 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR5 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 5 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0034146 ! toll-like receptor 5 signaling pathway

[Term]
id: GO:0034148
name: negative regulation of toll-like receptor 5 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR5 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 5 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034147 ! regulation of toll-like receptor 5 signaling pathway
relationship: negatively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway

[Term]
id: GO:0034149
name: positive regulation of toll-like receptor 5 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR5 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 5 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034147 ! regulation of toll-like receptor 5 signaling pathway
relationship: positively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway

[Term]
id: GO:0034150
name: toll-like receptor 6 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 6." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR6 signaling pathway" EXACT []
synonym: "toll-like receptor 6 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034151
name: regulation of toll-like receptor 6 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR6 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 6 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0034150 ! toll-like receptor 6 signaling pathway

[Term]
id: GO:0034152
name: negative regulation of toll-like receptor 6 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR6 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 6 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034151 ! regulation of toll-like receptor 6 signaling pathway
relationship: negatively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway

[Term]
id: GO:0034153
name: positive regulation of toll-like receptor 6 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR6 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 6 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034151 ! regulation of toll-like receptor 6 signaling pathway
relationship: positively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway

[Term]
id: GO:0034154
name: toll-like receptor 7 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 7." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR7 signaling pathway" EXACT []
synonym: "toll-like receptor 7 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034155
name: regulation of toll-like receptor 7 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR7 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 7 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0034154 ! toll-like receptor 7 signaling pathway

[Term]
id: GO:0034156
name: negative regulation of toll-like receptor 7 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR7 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 7 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034155 ! regulation of toll-like receptor 7 signaling pathway
relationship: negatively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway

[Term]
id: GO:0034157
name: positive regulation of toll-like receptor 7 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR7 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 7 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034155 ! regulation of toll-like receptor 7 signaling pathway
relationship: positively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway

[Term]
id: GO:0034158
name: toll-like receptor 8 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 8." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR8 signaling pathway" EXACT []
synonym: "toll-like receptor 8 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034159
name: regulation of toll-like receptor 8 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR8 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 8 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0034158 ! toll-like receptor 8 signaling pathway

[Term]
id: GO:0034160
name: negative regulation of toll-like receptor 8 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR8 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 8 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034159 ! regulation of toll-like receptor 8 signaling pathway
relationship: negatively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway

[Term]
id: GO:0034161
name: positive regulation of toll-like receptor 8 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR8 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 8 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034159 ! regulation of toll-like receptor 8 signaling pathway
relationship: positively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway

[Term]
id: GO:0034162
name: toll-like receptor 9 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 9." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR9 signaling pathway" EXACT []
synonym: "toll-like receptor 9 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034163
name: regulation of toll-like receptor 9 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR9 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 9 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0034162 ! toll-like receptor 9 signaling pathway

[Term]
id: GO:0034164
name: negative regulation of toll-like receptor 9 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR9 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 9 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034163 ! regulation of toll-like receptor 9 signaling pathway
relationship: negatively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway

[Term]
id: GO:0034165
name: positive regulation of toll-like receptor 9 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR9 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 9 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034163 ! regulation of toll-like receptor 9 signaling pathway
relationship: positively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway

[Term]
id: GO:0034166
name: toll-like receptor 10 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 10." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR10 signaling pathway" EXACT []
synonym: "toll-like receptor 10 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034167
name: regulation of toll-like receptor 10 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR10 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 10 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0034166 ! toll-like receptor 10 signaling pathway

[Term]
id: GO:0034168
name: negative regulation of toll-like receptor 10 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR10 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 10 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034167 ! regulation of toll-like receptor 10 signaling pathway
relationship: negatively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway

[Term]
id: GO:0034169
name: positive regulation of toll-like receptor 10 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR10 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 10 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034167 ! regulation of toll-like receptor 10 signaling pathway
relationship: positively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway

[Term]
id: GO:0034170
name: toll-like receptor 11 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 11." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR11 signaling pathway" EXACT []
synonym: "toll-like receptor 11 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034171
name: regulation of toll-like receptor 11 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR11 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 11 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0034170 ! toll-like receptor 11 signaling pathway

[Term]
id: GO:0034172
name: negative regulation of toll-like receptor 11 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR11 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 11 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034171 ! regulation of toll-like receptor 11 signaling pathway
relationship: negatively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway

[Term]
id: GO:0034173
name: positive regulation of toll-like receptor 11 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR11 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 11 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034171 ! regulation of toll-like receptor 11 signaling pathway
relationship: positively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway

[Term]
id: GO:0034174
name: toll-like receptor 12 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 12." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR12 signaling pathway" EXACT []
synonym: "toll-like receptor 12 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034175
name: regulation of toll-like receptor 12 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR12 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 12 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0034174 ! toll-like receptor 12 signaling pathway

[Term]
id: GO:0034176
name: negative regulation of toll-like receptor 12 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR12 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 12 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034175 ! regulation of toll-like receptor 12 signaling pathway
relationship: negatively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway

[Term]
id: GO:0034177
name: positive regulation of toll-like receptor 12 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR12 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 12 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034175 ! regulation of toll-like receptor 12 signaling pathway
relationship: positively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway

[Term]
id: GO:0034178
name: toll-like receptor 13 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 13." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "TLR13 signaling pathway" EXACT []
synonym: "toll-like receptor 13 signalling pathway" EXACT []
is_a: GO:0002224 ! toll-like receptor signaling pathway

[Term]
id: GO:0034179
name: regulation of toll-like receptor 13 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "regulation of TLR13 signaling pathway" EXACT []
synonym: "regulation of toll-like receptor 13 signalling pathway" EXACT []
is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway
relationship: regulates GO:0034178 ! toll-like receptor 13 signaling pathway

[Term]
id: GO:0034180
name: negative regulation of toll-like receptor 13 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "negative regulation of TLR13 signaling pathway" EXACT []
synonym: "negative regulation of toll-like receptor 13 signalling pathway" EXACT []
is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway
is_a: GO:0034179 ! regulation of toll-like receptor 13 signaling pathway
relationship: negatively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway

[Term]
id: GO:0034181
name: positive regulation of toll-like receptor 13 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678]
synonym: "positive regulation of TLR13 signaling pathway" EXACT []
synonym: "positive regulation of toll-like receptor 13 signalling pathway" EXACT []
is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway
is_a: GO:0034179 ! regulation of toll-like receptor 13 signaling pathway
relationship: positively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway

[Term]
id: GO:0034182
name: regulation of maintenance of mitotic sister chromatid cohesion
namespace: biological_process
def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation
is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion
relationship: regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion

[Term]
id: GO:0034183
name: negative regulation of maintenance of mitotic sister chromatid cohesion
namespace: biological_process
def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0034092 ! negative regulation of maintenance of sister chromatid cohesion
is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion
relationship: negatively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion

[Term]
id: GO:0034184
name: positive regulation of maintenance of mitotic sister chromatid cohesion
namespace: biological_process
def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw]
is_a: GO:0034093 ! positive regulation of maintenance of sister chromatid cohesion
is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion
relationship: positively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion

[Term]
id: GO:0034185
name: apolipoprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex." [GOC:BHF, GOC:rl]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0034186
name: apolipoprotein A-I binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with apolipoprotein A-I." [GOC:BHF, GOC:rl]
is_a: GO:0034185 ! apolipoprotein binding

[Term]
id: GO:0034187
name: apolipoprotein E binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with apolipoprotein E." [GOC:BHF, GOC:rl]
is_a: GO:0034185 ! apolipoprotein binding

[Term]
id: GO:0034188
name: apolipoprotein A-I receptor activity
namespace: molecular_function
def: "Combining with apolipoprotein A-I to initiate a change in cell activity." [GOC:BHF, GOC:rl]
is_a: GO:0030226 ! apolipoprotein receptor activity
is_a: GO:0034186 ! apolipoprotein A-I binding

[Term]
id: GO:0034189
name: very-low-density lipoprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with very-low-density lipoprotein, one of the classes of lipoproteins found in blood plasma in many animals." [GOC:BHF, GOC:mah]
synonym: "VLDL binding" EXACT []
is_a: GO:0008034 ! lipoprotein binding

[Term]
id: GO:0034190
name: apolipoprotein receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an apolipoprotein receptor." [GOC:BHF, GOC:rl]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0034191
name: apolipoprotein A-I receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an apolipoprotein A-I receptor." [GOC:BHF, GOC:rl]
comment: Note that this term is to be used only to annotate gene products that bind to lipid-free APOA1. For receptors that bind lipid-associated apolipoproteins (plasma lipoprotein particles), consider annotating to 'lipoprotein receptor activity ; GO:0030228' or its child terms.
is_a: GO:0034190 ! apolipoprotein receptor binding

[Term]
id: GO:0034192
name: D-galactonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-galactonate, the anion of D-galactonic acid." [GOC:mah]
subset: gosubset_prok
synonym: "D-galactonate metabolism" EXACT []
is_a: GO:0019583 ! galactonate metabolic process

[Term]
id: GO:0034193
name: L-galactonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-galactonate, the anion of L-galactonic acid." [GOC:mah]
subset: gosubset_prok
synonym: "L-galactonate metabolism" EXACT []
is_a: GO:0019583 ! galactonate metabolic process

[Term]
id: GO:0034194
name: D-galactonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid." [GOC:ai, GOC:mah]
subset: gosubset_prok
synonym: "D-galactonate breakdown" EXACT []
synonym: "D-galactonate catabolism" EXACT []
synonym: "D-galactonate degradation" EXACT []
xref: MetaCyc:GALACTCAT-PWY
is_a: GO:0019584 ! galactonate catabolic process
is_a: GO:0034192 ! D-galactonate metabolic process

[Term]
id: GO:0034195
name: L-galactonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-galactonate, the anion of L-galactonic acid." [GOC:ai, GOC:mah]
subset: gosubset_prok
synonym: "L-galactonate breakdown" EXACT []
synonym: "L-galactonate catabolism" EXACT []
synonym: "L-galactonate degradation" EXACT []
xref: MetaCyc:GALACTCAT-PWY
is_a: GO:0019584 ! galactonate catabolic process
is_a: GO:0034193 ! L-galactonate metabolic process

[Term]
id: GO:0034196
name: acylglycerol transport
namespace: biological_process
def: "The directed movement of an acylglycerol into, out of, within or between cells by means of some external agent such as a transporter or pore. An acylglycerol is any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:BHF, GOC:rl]
synonym: "glyceride transport" EXACT []
is_a: GO:0006869 ! lipid transport

[Term]
id: GO:0034197
name: triglyceride transport
namespace: biological_process
def: "The directed movement of triglyceride into, out of, within or between cells by means of some external agent such as a transporter or pore. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [GOC:BHF, GOC:rl]
synonym: "triacylglycerol transport" EXACT []
is_a: GO:0034196 ! acylglycerol transport

[Term]
id: GO:0034198
name: cellular response to amino acid starvation
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0034199
name: activation of protein kinase A activity
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme protein kinase A." [GOC:pd]
synonym: "protein kinase A activation" EXACT []
xref: Reactome:163615 "PKA activation"
xref: Reactome:448757 "PKA activation"
xref: Reactome:469872 "PKA activation"
xref: Reactome:487576 "PKA activation"
xref: Reactome:507532 "PKA activation"
xref: Reactome:517515 "PKA activation"
xref: Reactome:526384 "PKA activation"
xref: Reactome:531299 "PKA activation"
xref: Reactome:536673 "PKA activation"
xref: Reactome:542406 "PKA activation"
xref: Reactome:547755 "PKA activation"
xref: Reactome:557839 "PKA activation"
xref: Reactome:581643 "PKA activation"
xref: Reactome:592555 "PKA activation"
xref: Reactome:595375 "PKA activation"
is_a: GO:0032147 ! activation of protein kinase activity

[Term]
id: GO:0034200
name: D,D-heptose 1,7-bisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-beta-D-heptose 1,7-bisphosphate + H2O = D-beta-D-heptose 1-phosphate + phosphate." [MetaCyc:RXN0-4361, PMID:11279237]
xref: MetaCyc:RXN0-4361
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0034201
name: response to oleic acid
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus." [ChEBI:16196, GOC:lp]
synonym: "response to oleate" EXACT [GOC:mah]
is_a: GO:0070542 ! response to fatty acid

[Term]
id: GO:0034202
name: glycolipid-translocating activity
namespace: molecular_function
def: "Catalysis of the movement of glycolipids from one membrane face to the other (glycolipid 'flippase' activity)." [GOC:krc, PMID:11807558]
synonym: "flippase activity" BROAD []
is_a: GO:0017089 ! glycolipid transporter activity

[Term]
id: GO:0034203
name: glycolipid translocation
namespace: biological_process
def: "The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:go_curators, PMID:11807558]
subset: gosubset_prok
synonym: "flippase" RELATED []
synonym: "scramblase" RELATED []
is_a: GO:0034204 ! lipid translocation
is_a: GO:0046836 ! glycolipid transport

[Term]
id: GO:0034204
name: lipid translocation
namespace: biological_process
def: "The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:mah]
is_a: GO:0006869 ! lipid transport
is_a: GO:0016044 ! cellular membrane organization

[Term]
id: GO:0034205
name: beta-amyloid formation
namespace: biological_process
def: "The generation of beta-amyloid by cleavage of the amyloid precursor protein (APP)." [GOC:mah]
comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because beta-amyloid can only be formed by the proteolysis of a larger molecule (see term definition). The word 'formation' is therefore used in place of biosynthesis.
is_a: GO:0042987 ! amyloid precursor protein catabolic process
is_a: GO:0050435 ! beta-amyloid metabolic process

[Term]
id: GO:0034206
name: enhanceosome
namespace: cellular_component
def: "A protein-DNA complex formed by the association of a distinct set of general and specific transcription factors with a region of enhancer DNA. The cooperative assembly of an enhanceosome confers specificity of transcriptional regulation." [PMID:11250145, PMID:17574024]
xref: Wikipedia:Enhanceosome
is_a: GO:0032993 ! protein-DNA complex

[Term]
id: GO:0034207
name: steroid acetylation
namespace: biological_process
def: "The addition of an acetyl group to a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:mah]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0034208
name: steroid deacetylation
namespace: biological_process
def: "The removal of an acetyl group from a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:mah]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0034209
name: sterol acetylation
namespace: biological_process
def: "The addition of an acetyl group to a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:rb, PMID:18034159]
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:0034207 ! steroid acetylation

[Term]
id: GO:0034210
name: sterol deacetylation
namespace: biological_process
def: "The removal of an acetyl group from a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:rb, PMID:18034159]
is_a: GO:0016125 ! sterol metabolic process
is_a: GO:0034208 ! steroid deacetylation

[Term]
id: GO:0034211
name: GTP-dependent protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of GTP." [GOC:ecd, PMID:17200152]
xref: EC:2.7.11.-
is_a: GO:0004674 ! protein serine/threonine kinase activity

[Term]
id: GO:0034212
name: peptide N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide." [GOC:mah]
subset: gosubset_prok
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0034213
name: quinolinate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:mah]
synonym: "quinolinate breakdown" EXACT []
synonym: "quinolinate catabolism" EXACT []
synonym: "quinolinate degradation" EXACT []
is_a: GO:0046874 ! quinolinate metabolic process

[Term]
id: GO:0034214
name: protein hexamerization
namespace: biological_process
def: "The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits." [GOC:ecd]
subset: gosubset_prok
synonym: "protein hexamer assembly" EXACT []
synonym: "protein hexamer biosynthesis" EXACT []
synonym: "protein hexamer biosynthetic process" EXACT []
synonym: "protein hexamer formation" EXACT []
is_a: GO:0051259 ! protein oligomerization

[Term]
id: GO:0034215
name: thiamin:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamin(out) + H+(out) = thiamin(in) + H+(in)." [GOC:mah]
synonym: "thiamin:proton symporter activity" EXACT []
synonym: "thiamine:hydrogen symporter activity" EXACT []
synonym: "thiamine:proton symporter activity" EXACT []
is_a: GO:0015295 ! solute:hydrogen symporter activity
is_a: GO:0015403 ! thiamin uptake transmembrane transporter activity

[Term]
id: GO:0034216
name: high-affinity thiamin:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamin(out) + H+(out) = thiamin(in) + H+(in). In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah]
synonym: "high affinity thiamin:hydrogen symporter activity" EXACT []
synonym: "high-affinity thiamin:proton symporter activity" EXACT []
synonym: "high-affinity thiamine:hydrogen symporter activity" EXACT []
synonym: "high-affinity thiamine:proton symporter activity" EXACT []
is_a: GO:0034215 ! thiamin:hydrogen symporter activity

[Term]
id: GO:0034217
name: ascospore wall chitin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall chitin anabolism" EXACT []
synonym: "ascospore wall chitin biosynthesis" EXACT []
synonym: "ascospore wall chitin formation" EXACT []
synonym: "ascospore wall chitin synthesis" EXACT []
is_a: GO:0006038 ! cell wall chitin biosynthetic process
is_a: GO:0034218 ! ascospore wall chitin metabolic process
is_a: GO:0044106 ! cellular amine metabolic process
relationship: part_of GO:0070591 ! ascospore wall biogenesis

[Term]
id: GO:0034218
name: ascospore wall chitin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall chitin metabolism" EXACT []
is_a: GO:0006037 ! cell wall chitin metabolic process

[Term]
id: GO:0034219
name: carbohydrate transmembrane transport
namespace: biological_process
def: "The process whereby a carbohydrate is transported from one side of a membrane to the other." [GOC:mah]
synonym: "transmembrane carbohydrate transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0034220
name: ion transmembrane transport
namespace: biological_process
def: "A process whereby an ion is transported from one side of a membrane to the other." [GOC:mah]
synonym: "transmembrane ion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006811 ! ion transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0034221
name: fungal-type cell wall chitin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of vegetatively growing fungal cells." [GOC:mah]
synonym: "fungal-type cell wall chitin anabolism" EXACT []
synonym: "fungal-type cell wall chitin biosynthesis" EXACT []
synonym: "fungal-type cell wall chitin formation" EXACT []
synonym: "fungal-type cell wall chitin synthesis" EXACT []
is_a: GO:0006038 ! cell wall chitin biosynthetic process
is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process

[Term]
id: GO:0034222
name: regulation of cell wall chitin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin in a cell wall." [GOC:mah]
synonym: "regulation of cell wall chitin metabolism" EXACT []
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0032882 ! regulation of chitin metabolic process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0006037 ! cell wall chitin metabolic process

[Term]
id: GO:0034223
name: regulation of ascospore wall chitin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ascospore wall chitin." [GOC:mah]
synonym: "regulation of ascospore wall chitin anabolism" EXACT []
synonym: "regulation of ascospore wall chitin biosynthesis" EXACT []
synonym: "regulation of ascospore wall chitin formation" EXACT []
synonym: "regulation of ascospore wall chitin synthesis" EXACT []
is_a: GO:0032884 ! regulation of cell wall chitin biosynthetic process
is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0034307 ! regulation of ascospore formation
relationship: regulates GO:0034217 ! ascospore wall chitin biosynthetic process

[Term]
id: GO:0034224
name: cellular response to zinc ion starvation
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of zinc ions." [GOC:mah]
synonym: "ellular response to zinc ion limitation" EXACT []
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0034225
name: regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation
namespace: biological_process
def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of zinc ions." [GOC:mah]
synonym: "regulation of transcription from RNA polymerase II promoter in response to zinc deficiency" EXACT []
synonym: "regulation of transcription from RNA polymerase II promoter in response to zinc ion limitation" EXACT []
is_a: GO:0034224 ! cellular response to zinc ion starvation
is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress

[Term]
id: GO:0034226
name: lysine import
namespace: biological_process
def: "The directed movement of lysine, 2,6-diaminohexanoic acid, into a cell or organelle." [GOC:jl, GOC:mah]
synonym: "L-lysine import" NARROW []
synonym: "lysine uptake" EXACT []
is_a: GO:0015819 ! lysine transport
is_a: GO:0043090 ! amino acid import

[Term]
id: GO:0034227
name: tRNA thio-modification
namespace: biological_process
def: "The addition a sulfur atom to a nucleotide in a tRNA molecule." [GOC:mcc, PMID:12549933, PMID:14722066]
subset: gosubset_prok
synonym: "tRNA sulfurtransferase activity" RELATED [GOC:mah]
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0034228
name: ethanolamine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of ethanolamine from one side of the membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine." [GOC:rn, PMID:3514579]
subset: gosubset_prok
synonym: "2-aminoethanol transmembrane transporter activity" EXACT []
synonym: "ethanolamine permease activity" EXACT []
synonym: "monoethanolamine transmembrane transporter activity" EXACT []
is_a: GO:0005275 ! amine transmembrane transporter activity

[Term]
id: GO:0034229
name: ethanolamine transport
namespace: biological_process
def: "The directed movement of ethanolamine into, out of, within or between cells by means of some external agent such as a transporter or pore. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine." [GOC:rn, PMID:3514579]
synonym: "2-aminoethanol transport" EXACT []
synonym: "monoethanolamine transport" EXACT []
is_a: GO:0015837 ! amine transport
is_a: GO:0015850 ! organic alcohol transport

[Term]
id: GO:0034230
name: enkephalin processing
namespace: biological_process
def: "The formation of mature enkephalin, a pentapeptide hormone involved in regulating pain and nociception in the body by proteolytic processing of enkephalin propeptide." [GOC:BHF, GOC:mah, GOC:rl, PMID:8262946]
synonym: "enkephalin formation" EXACT []
synonym: "peptide enkephalin formation" EXACT []
synonym: "peptide enkephalin processing" EXACT []
is_a: GO:0016486 ! peptide hormone processing

[Term]
id: GO:0034231
name: islet amyloid polypeptide processing
namespace: biological_process
def: "The formation of mature islet amyloid polypeptide (IAPP) by posttranslational processing of pro-islet amyloid polypeptide (pro-IAPP)." [GOC:BHF, GOC:rl, PMID:15983213, PMID:8262946]
synonym: "IAPP formation" EXACT []
synonym: "IAPP processing" EXACT []
synonym: "islet amyloid peptide formation" EXACT []
synonym: "islet amyloid peptide processing" EXACT []
synonym: "islet amyloid polypeptide formation" RELATED []
is_a: GO:0016486 ! peptide hormone processing

[Term]
id: GO:0034232
name: ascospore wall chitin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall chitin breakdown" EXACT []
synonym: "ascospore wall chitin catabolism" EXACT []
synonym: "ascospore wall chitin degradation" EXACT []
is_a: GO:0006039 ! cell wall chitin catabolic process
is_a: GO:0034218 ! ascospore wall chitin metabolic process

[Term]
id: GO:0034233
name: regulation of cell wall chitin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cell wall chitin." [GOC:mah]
synonym: "regulation of cell wall chitin breakdown" EXACT []
synonym: "regulation of cell wall chitin catabolism" EXACT []
synonym: "regulation of cell wall chitin degradation" EXACT []
is_a: GO:0034222 ! regulation of cell wall chitin metabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
relationship: regulates GO:0006039 ! cell wall chitin catabolic process

[Term]
id: GO:0034234
name: regulation of ascospore wall chitin catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of ascospore wall chitin." [GOC:mah]
synonym: "regulation of ascospore wall chitin breakdown" EXACT []
synonym: "regulation of ascospore wall chitin catabolism" EXACT []
synonym: "regulation of ascospore wall chitin degradation" EXACT []
is_a: GO:0034233 ! regulation of cell wall chitin catabolic process
relationship: regulates GO:0034232 ! ascospore wall chitin catabolic process

[Term]
id: GO:0034235
name: GPI anchor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw]
comment: Note that this term should be used to annotate gene products that interact non-covalently with GPI anchors, and not proteins that have GPI anchors covalently attached.
synonym: "glycosylphosphatidylinositol binding" EXACT []
is_a: GO:0035091 ! phosphoinositide binding

[Term]
id: GO:0034236
name: protein kinase A catalytic subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A." [GOC:mah]
synonym: "PKA catalytic subunit binding" EXACT []
is_a: GO:0019901 ! protein kinase binding
is_a: GO:0051018 ! protein kinase A binding

[Term]
id: GO:0034237
name: protein kinase A regulatory subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with one or both of the regulatory subunits of protein kinase A." [GOC:mah]
synonym: "PKA regulatory subunit binding" EXACT []
synonym: "protein kinase A anchoring activity" RELATED []
is_a: GO:0051018 ! protein kinase A binding

[Term]
id: GO:0034238
name: macrophage fusion
namespace: biological_process
def: "The binding and fusion of a macrophage to one or more other cells to form a multinucleated cell." [GOC:sl]
is_a: GO:0000768 ! syncytium formation by plasma membrane fusion

[Term]
id: GO:0034239
name: regulation of macrophage fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage fusion." [GOC:mah]
is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion
relationship: regulates GO:0034238 ! macrophage fusion

[Term]
id: GO:0034240
name: negative regulation of macrophage fusion
namespace: biological_process
def: "Any process that stops, prevents, or decreases the frequency, rate or extent of macrophage fusion." [GOC:mah]
is_a: GO:0034239 ! regulation of macrophage fusion
is_a: GO:0034242 ! negative regulation of syncytium formation by plasma membrane fusion
relationship: negatively_regulates GO:0034238 ! macrophage fusion

[Term]
id: GO:0034241
name: positive regulation of macrophage fusion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage fusion." [GOC:mah]
is_a: GO:0034239 ! regulation of macrophage fusion
is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion
relationship: positively_regulates GO:0034238 ! macrophage fusion

[Term]
id: GO:0034242
name: negative regulation of syncytium formation by plasma membrane fusion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mah]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion
relationship: negatively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion

[Term]
id: GO:0034243
name: regulation of RNA elongation from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah]
synonym: "regulation of transcription elongation from RNA polymerase II promoter" BROAD []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0032784 ! regulation of RNA elongation
relationship: regulates GO:0006368 ! RNA elongation from RNA polymerase II promoter

[Term]
id: GO:0034244
name: negative regulation of RNA elongation from RNA polymerase II promoter
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah]
synonym: "negative regulation of transcription elongation from RNA polymerase II promoter" BROAD []
is_a: GO:0032785 ! negative regulation of RNA elongation
is_a: GO:0034243 ! regulation of RNA elongation from RNA polymerase II promoter
relationship: negatively_regulates GO:0006368 ! RNA elongation from RNA polymerase II promoter

[Term]
id: GO:0034245
name: mitochondrial DNA-directed RNA polymerase complex
namespace: cellular_component
def: "A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form." [GOC:krc, GOC:mah, PMID:7929382]
synonym: "mitochondrial RNA polymerase complex" BROAD []
synonym: "mitochondrial RNA polymerase holoenzyme complex" EXACT []
is_a: GO:0000428 ! DNA-directed RNA polymerase complex
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0034246
name: mitochondrial transcription initiation factor activity
namespace: molecular_function
def: "A transcription factor activity that confers promoter specificity upon mitochondrial RNA polymerase, in a manner analogous to eubacterial sigma factors." [GOC:mah]
synonym: "mitochondrial polymerase transcription factor activity" EXACT []
synonym: "mitochondrial transcription factor activity" RELATED []
is_a: GO:0016986 ! transcription initiation factor activity

[Term]
id: GO:0034247
name: snoRNA splicing
namespace: biological_process
def: "The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA." [GOC:mah]
is_a: GO:0008380 ! RNA splicing
is_a: GO:0043144 ! snoRNA processing

[Term]
id: GO:0034248
name: regulation of cellular amide metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]
synonym: "regulation of amide metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
relationship: regulates GO:0043603 ! cellular amide metabolic process

[Term]
id: GO:0034249
name: negative regulation of cellular amide metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]
synonym: "negative regulation of amide metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
relationship: negatively_regulates GO:0043603 ! cellular amide metabolic process

[Term]
id: GO:0034250
name: positive regulation of cellular amide metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah]
synonym: "positive regulation of amide metabolism" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
relationship: positively_regulates GO:0043603 ! cellular amide metabolic process

[Term]
id: GO:0034251
name: regulation of cellular amide catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah]
synonym: "regulation of amide breakdown" EXACT []
synonym: "regulation of amide catabolism" EXACT []
synonym: "regulation of amide degradation" EXACT []
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
relationship: regulates GO:0043605 ! cellular amide catabolic process

[Term]
id: GO:0034252
name: negative regulation of cellular amide catabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah]
synonym: "negative regulation of amide breakdown" EXACT []
synonym: "negative regulation of amide catabolism" EXACT []
synonym: "negative regulation of amide degradation" RELATED []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0034249 ! negative regulation of cellular amide metabolic process
is_a: GO:0034251 ! regulation of cellular amide catabolic process
relationship: negatively_regulates GO:0043605 ! cellular amide catabolic process

[Term]
id: GO:0034253
name: positive regulation of cellular amide catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah]
synonym: "positive regulation of amide breakdown" EXACT []
synonym: "positive regulation of amide catabolism" EXACT []
synonym: "positive regulation of amide degradation" RELATED []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0034250 ! positive regulation of cellular amide metabolic process
is_a: GO:0034251 ! regulation of cellular amide catabolic process
relationship: positively_regulates GO:0043605 ! cellular amide catabolic process

[Term]
id: GO:0034254
name: regulation of urea catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of urea." [GOC:mah]
synonym: "regulation of urea breakdown" EXACT []
synonym: "regulation of urea catabolism" EXACT []
synonym: "regulation of urea degradation" EXACT []
is_a: GO:0034251 ! regulation of cellular amide catabolic process
is_a: GO:0034255 ! regulation of urea metabolic process
relationship: regulates GO:0043419 ! urea catabolic process

[Term]
id: GO:0034255
name: regulation of urea metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving urea." [GOC:mah]
synonym: "regulation of urea metabolism" EXACT []
is_a: GO:0034248 ! regulation of cellular amide metabolic process
relationship: regulates GO:0019627 ! urea metabolic process

[Term]
id: GO:0034256
name: chlorophyll(ide) b reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 71-hydroxychlorophyll(ide) a + NAD(P)+ = chlorophyll(ide) b + NAD(P)H + H+." [EC:1.1.1.294, MetaCyc:RXN-7678]
synonym: "Chl b reductase activity" EXACT []
synonym: "chlorophyll b reductase activity" EXACT []
synonym: "chlorophyllide b reductase activity" EXACT []
xref: EC:1.1.1.294
xref: MetaCyc:RXN-7678
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034257
name: nicotinamide riboside transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other." [GOC:se]
is_a: GO:0005337 ! nucleoside transmembrane transporter activity

[Term]
id: GO:0034258
name: nicotinamide riboside transport
namespace: biological_process
def: "The directed movement of a nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:se]
is_a: GO:0015858 ! nucleoside transport

[Term]
id: GO:0034259
name: negative regulation of Rho GTPase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of activity of a GTPase of the Rho family." [GOC:mah]
synonym: "down regulation of Rho GTPase activity" EXACT []
synonym: "down-regulation of Rho GTPase activity" EXACT []
synonym: "downregulation of Rho GTPase activity" EXACT []
synonym: "inhibition of Rho GTPase activity" NARROW []
is_a: GO:0032319 ! regulation of Rho GTPase activity
is_a: GO:0034261 ! negative regulation of Ras GTPase activity

[Term]
id: GO:0034260
name: negative regulation of GTPase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of GTP hydrolysis by a GTPase." [GOC:mah]
synonym: "down regulation of GTPase activity" EXACT []
synonym: "down-regulation of GTPase activity" EXACT []
synonym: "downregulation of GTPase activity" EXACT []
synonym: "inhibition of GTPase activity" NARROW []
synonym: "negative regulation of guanosinetriphosphatase activity" EXACT []
is_a: GO:0043087 ! regulation of GTPase activity
is_a: GO:0051346 ! negative regulation of hydrolase activity

[Term]
id: GO:0034261
name: negative regulation of Ras GTPase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of activity of a GTPase of the Ras superfamily." [GOC:mah]
synonym: "down regulation of Ras GTPase activity" EXACT []
synonym: "down-regulation of Ras GTPase activity" EXACT []
synonym: "downregulation of Ras GTPase activity" EXACT []
synonym: "inhibition of Ras GTPase activity" NARROW []
is_a: GO:0032318 ! regulation of Ras GTPase activity
is_a: GO:0034260 ! negative regulation of GTPase activity

[Term]
id: GO:0034263
name: autophagy in response to ER overload
namespace: biological_process
def: "The process by which cells digest parts of their own cytoplasm in response to the accumulation of misfolded proteins in the endoplasmic reticulum." [GOC:mah]
synonym: "autophagy in response to endoplasmic reticulum overload" EXACT []
synonym: "autophagy in response to ER stress" EXACT []
is_a: GO:0006914 ! autophagy
is_a: GO:0006983 ! ER overload response

[Term]
id: GO:0034264
name: isopentenyl adenine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168]
synonym: "isopentenyl adenine metabolism" EXACT []
synonym: "isopentenyladenine metabolic process" EXACT []
is_a: GO:0009690 ! cytokinin metabolic process

[Term]
id: GO:0034265
name: isopentenyl adenine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168]
subset: gosubset_prok
synonym: "isopentenyl adenine anabolism" EXACT []
synonym: "isopentenyl adenine biosynthesis" EXACT []
synonym: "isopentenyl adenine formation" EXACT []
synonym: "isopentenyl adenine synthesis" EXACT []
synonym: "isopentenyladenine biosynthetic process" EXACT []
is_a: GO:0009691 ! cytokinin biosynthetic process
is_a: GO:0034264 ! isopentenyl adenine metabolic process

[Term]
id: GO:0034266
name: isopentenyl adenine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168]
subset: gosubset_prok
synonym: "isopentenyl adenine breakdown" EXACT []
synonym: "isopentenyl adenine catabolism" EXACT []
synonym: "isopentenyl adenine degradation" EXACT []
synonym: "isopentenyladenine catabolic process" EXACT []
is_a: GO:0009823 ! cytokinin catabolic process
is_a: GO:0034264 ! isopentenyl adenine metabolic process

[Term]
id: GO:0034267
name: discadenine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [ChEBI:15955, GOC:mah]
synonym: "discadenine metabolism" EXACT []
is_a: GO:0009690 ! cytokinin metabolic process

[Term]
id: GO:0034268
name: discadenine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [ChEBI:15955, GOC:mah]
synonym: "discadenine anabolism" EXACT []
synonym: "discadenine biosynthesis" EXACT []
synonym: "discadenine formation" EXACT []
synonym: "discadenine synthesis" EXACT []
is_a: GO:0009691 ! cytokinin biosynthetic process
is_a: GO:0034267 ! discadenine metabolic process

[Term]
id: GO:0034269
name: discadenine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [ChEBI:15955, GOC:mah]
synonym: "discadenine breakdown" EXACT []
synonym: "discadenine catabolism" EXACT []
synonym: "discadenine degradation" EXACT []
is_a: GO:0009823 ! cytokinin catabolic process
is_a: GO:0034267 ! discadenine metabolic process

[Term]
id: GO:0034270
name: CVT complex
namespace: cellular_component
def: "A protein complex that is involved in the CVT pathway. In budding yeast, the CVT complex consists of multimers of preApe1p." [GOC:rb, PMID:15659643]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034271
name: phosphatidylinositol 3-kinase complex I
namespace: cellular_component
def: "A protein complex that posseses phosphatidylinositol 3-kinase activity and is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Atg14p and Vps15p." [GOC:rb, PMID:11157979, PMID:16421251]
comment: Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'.
synonym: "PtdIns-3-kinase complex I" EXACT []
is_a: GO:0005942 ! phosphoinositide 3-kinase complex

[Term]
id: GO:0034272
name: phosphatidylinositol 3-kinase complex II
namespace: cellular_component
def: "A protein complex that posseses phosphatidylinositol 3-kinase activity and is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, VPS38 and Vps15p." [GOC:rb, PMID:11157979, PMID:16421251]
comment: Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'.
synonym: "PtdIns-3-kinase complex II" EXACT []
is_a: GO:0005942 ! phosphoinositide 3-kinase complex

[Term]
id: GO:0034273
name: Atg1p signaling complex
namespace: cellular_component
def: "A protein complex that contains a protein kinase and is required for the autophagosome formation. In budding yeast this complex consists of the kinase Atg1p, Atg13p and Atg17p." [GOC:rb, PMID:15743910]
synonym: "Atg1p signalling complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034274
name: Atg12-Atg5-Atg16 complex
namespace: cellular_component
def: "A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p." [GOC:rb, PMID:17986448]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034275
name: kynurenic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid." [ChEBI:18344, GOC:mah]
synonym: "4-hydroxyquinoline-2-carboxylic acid metabolic process" EXACT []
synonym: "kynurenic acid metabolism" EXACT []
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0034276
name: kynurenic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid." [ChEBI:18344, GOC:mah]
synonym: "4-hydroxyquinoline-2-carboxylic acid biosynthetic process" EXACT []
synonym: "kynurenic acid anabolism" EXACT []
synonym: "kynurenic acid biosynthesis" EXACT []
synonym: "kynurenic acid formation" RELATED []
synonym: "kynurenic acid synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0034275 ! kynurenic acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0034277
name: ent-cassa-12,15-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate." [MetaCyc:RXN-4881]
xref: MetaCyc:RXN-4881
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034278
name: stemar-13-ene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-syn-copalyl diphosphate = stemar-13-ene + diphosphate." [MetaCyc:RXN-4882]
xref: MetaCyc:RXN-4882
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034279
name: syn-pimara-7,15-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-syn-copalyl diphosphate = (-)-9-beta-pimara-7,15-diene + diphosphate." [MetaCyc:RXN-4883]
xref: MetaCyc:RXN-4883
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034280
name: ent-sandaracopimaradiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimaradiene + diphosphate." [MetaCyc:RXN-4884]
synonym: "ent-pimaradiene synthase activity" BROAD []
xref: MetaCyc:RXN-4884
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034281
name: ent-isokaurene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate." [PMID:17141283]
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034282
name: ent-pimara-8(14),15-diene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-copalyl diphosphate = ent- pimara-8(14),15-diene + diphosphate." [PMID:17141283]
synonym: "ent-pimaradiene synthase activity" BROAD []
xref: MetaCyc:RXN-7788
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034283
name: syn-stemod-13(17)-ene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: syn-copalyl diphosphate = stemod-13(17)-ene + diphosphate." [PMID:17141283]
synonym: "exo-stemodene synthase activity" EXACT []
synonym: "stemod-13(17)-ene synthase activity" EXACT []
synonym: "stemodene synthase activity" EXACT []
synonym: "syn-stemodene synthase activity" EXACT []
xref: MetaCyc:RXN-9291
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034284
name: response to monosaccharide stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah]
is_a: GO:0009743 ! response to carbohydrate stimulus

[Term]
id: GO:0034285
name: response to disaccharide stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus." [GOC:sart]
is_a: GO:0009743 ! response to carbohydrate stimulus

[Term]
id: GO:0034286
name: response to maltose stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus." [GOC:sart]
is_a: GO:0034285 ! response to disaccharide stimulus

[Term]
id: GO:0034287
name: detection of monosaccharide stimulus
namespace: biological_process
def: "The series of events in which a stimulus from a monosaccharide is received and converted into a molecular signal." [GOC:mah]
synonym: "perception of monosaccharide stimulus" RELATED []
is_a: GO:0009730 ! detection of carbohydrate stimulus
is_a: GO:0034284 ! response to monosaccharide stimulus

[Term]
id: GO:0034288
name: detection of disaccharide stimulus
namespace: biological_process
def: "The series of events in which a stimulus from a disaccharide is received and converted into a molecular signal." [GOC:sart]
synonym: "perception of disaccharide stimulus" RELATED []
is_a: GO:0009730 ! detection of carbohydrate stimulus
is_a: GO:0034285 ! response to disaccharide stimulus

[Term]
id: GO:0034289
name: detection of maltose stimulus
namespace: biological_process
def: "The series of events in which a maltose stimulus is received by a cell and converted into a molecular signal." [GOC:sart]
synonym: "perception of maltose stimulus" RELATED []
is_a: GO:0034286 ! response to maltose stimulus
is_a: GO:0034288 ! detection of disaccharide stimulus

[Term]
id: GO:0034290
name: holin activity
namespace: molecular_function
def: "Catalysis of the temporally-regulated formation of a transmembrane protein hole that directly or indirectly allows murein hydrolyases to access their cell wall substrate." [GOC:jh2, PMID:1406491]
is_a: GO:0015267 ! channel activity

[Term]
id: GO:0034291
name: canonical holin activity
namespace: molecular_function
def: "Catalysis of the temporally-regulated formation of a non-specific transmembrane protein hole that allows release of a fully-folded phage-encoded endolysin (murein-degradase) from the cell." [GOC:jh2, GOC:mah, PMID:1406491]
is_a: GO:0034290 ! holin activity

[Term]
id: GO:0034292
name: pinholin activity
namespace: molecular_function
def: "Catalysis of the temporally-regulated formation of a transmembrane protein hole that allows the passage of ions, causing a lethal, irreversible depolarization of the cell membrane." [GOC:jh2, GOC:mah, PMID:1406491]
is_a: GO:0034290 ! holin activity

[Term]
id: GO:0034293
name: sexual sporulation
namespace: biological_process
def: "The formation of spores derived from the products of meiosis." [GOC:mah]
synonym: "meiotic spore formation" EXACT []
synonym: "meiotic sporulation" EXACT []
synonym: "sexual spore formation" EXACT []
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0019953 ! sexual reproduction
is_a: GO:0043934 ! sporulation
is_a: GO:0048610 ! reproductive cellular process

[Term]
id: GO:0034294
name: sexual spore wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a sexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis." [GOC:mah]
synonym: "sexual spore wall formation" EXACT []
is_a: GO:0042244 ! spore wall assembly
relationship: part_of GO:0034293 ! sexual sporulation

[Term]
id: GO:0034295
name: basidiospore formation
namespace: biological_process
def: "The process by which spores form outside a specialized end cell known as a basidium. Basidia are characteristic of the basidiomycete fungi (phylum Basidiomycota), and give rise to spores that each contain a haploid nucleus that is the product of meiosis. The spores are usually attached to the basidium by short spikes called sterigmata (singular: sterigma). In most basidiomycetes there are four sterigmata (and four spores) to a basidium." [GOC:ds, GOC:mah, http://www.gsbs.utmb.edu/microbook/ch073.htm, http://www.ilmyco.gen.chicago.il.us/Terms/basid133.html]
is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034296
name: zygospore formation
namespace: biological_process
def: "The process by which zygospores are formed. Zygospores are characteristic of the zygomycete fungi (phylum Zygomycota) thick-walled and darkly colored, and usually heavily ornamented as well, with many spines or ridges. It is formed between two specialized organs called suspensors, which are themselves usually heavily ornamented, one from each mating partner. The zygospore forms between them and then breaks away." [GOC:ds, GOC:mah, http://www.ilmyco.gen.chicago.il.us/Terms/zygos581.html]
is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034297
name: oidium formation
namespace: biological_process
def: "The process by which oidia, a type of asexual spore found in fungi, are formed. Oidia are borne a few at a time on very simple hyphae that protrude a short distance into the substrate, and are usually presumed not to constitute the main reproductive strategy of the fungus." [GOC:mah, http://www.ilmyco.gen.chicago.il.us/Terms/oidiu163.html]
is_a: GO:0030436 ! asexual sporulation

[Term]
id: GO:0034298
name: arthrospore formation
namespace: biological_process
def: "The formation of conidia by the conversion of a pre-existing hypha. An arthrospore is produced by the last cell on a hypha breaking off and dispersing. Usually the walls thicken and the cell(s) separates before swelling of each spore. Sometimes further septa form in each cell prior to disarticulation." [GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_a_b.shtml#arthrospore, http://www.ilmyco.gen.chicago.il.us/Terms/arthr620.html]
synonym: "arthroconidium formation" EXACT [http://medical.merriam-webster.com/medical/medical?book=Medical&va=arthroconidium]
is_a: GO:0048315 ! conidium formation

[Term]
id: GO:0034299
name: reproductive blastospore formation
namespace: biological_process
def: "The formation of a spore following the marked enlargement of part of a cell before separation by a septum. Blastospores are a type of asexual spore found in some fungi, most notably the class Glomeromycota." [GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_a_b.shtml#blastospore, http://bugs.bio.usyd.edu.au/Mycology/Taxonomy/glomeromycota.shtml]
comment: Note that this term should not be confused with the usage of 'blastospore' to mean any yeast-form fungal cell, as in Candida species.
synonym: "blastoconidium formation" EXACT [http://cancerweb.ncl.ac.uk/cgi-bin/omd?Blastoconidium]
is_a: GO:0048315 ! conidium formation

[Term]
id: GO:0034300
name: sporangiospore formation
namespace: biological_process
def: "The process by which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:ds, GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_n_z.shtml]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034301
name: endospore formation
namespace: biological_process
def: "The process by which a cell gives rise to an endospore, a dormant, highly resistant spore with a thick wall that forms within the mother cell. Endospores are produced by some low G+C Gram-positive bacteria in response to harsh conditions." [GOC:ds, GOC:mah, ISBN:0470090278]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034302
name: akinete formation
namespace: biological_process
def: "The process by which an akinete, a thick-walled (encysted) dormant cell derived from the enlargement of a vegetative cell, is formed. Akinetes typically have granular cytoplasm, are more resistant to environmental extremes than vegetative cells, and are characteristic of several groups of Cyanobacteria." [GOC:ds, GOC:mah, http://www.msu.edu/course/bot/423/algalglossary.htm#Reproductive, PMID:11948167]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034303
name: myxospore formation
namespace: biological_process
def: "The process by which differentiated, resting cells are formed, usually within a fruiting body by Myxobacteria. The myxospore is more resistant to high temperature, dessication, and UV than vegetative myxobacteria." [GOC:ds, ISBN:0122268008]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034304
name: actinomycete-type spore formation
namespace: biological_process
def: "The process by which differentiated, resting cells are formed from a substrate mycelium; characteristic of many members of the order Actinomycetales." [GOC:ds, ISBN:0122268008]
is_a: GO:0022413 ! reproductive process in single-celled organism
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0034305
name: regulation of asexual sporulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore formation from the products of mitosis." [GOC:mah]
synonym: "regulation of asexual spore formation" EXACT []
synonym: "regulation of mitotic spore formation" EXACT []
synonym: "regulation of mitotic sporulation" EXACT []
is_a: GO:0043937 ! regulation of sporulation
relationship: regulates GO:0030436 ! asexual sporulation

[Term]
id: GO:0034306
name: regulation of sexual sporulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore formation from the products of meiosis. An example of this is found in Saccharomyces cerevisiae." [GOC:mah]
synonym: "MAPKKK cascade during sporulation" NARROW []
synonym: "regulation of meiotic spore formation" EXACT []
synonym: "regulation of meiotic sporulation" EXACT []
synonym: "regulation of sexual spore formation" EXACT []
is_a: GO:0043937 ! regulation of sporulation
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0034293 ! sexual sporulation

[Term]
id: GO:0034307
name: regulation of ascospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ascospore formation. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah]
synonym: "MAPKKK cascade during sporulation" NARROW []
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0030437 ! ascospore formation

[Term]
id: GO:0034308
name: monohydric alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one hydroxyl group attached to a saturated carbon atom." [ChEBI:30879, GOC:mah]
subset: gosubset_prok
synonym: "monohydric alcohol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process

[Term]
id: GO:0034309
name: monohydric alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monohydric alcohols, any of a class of alkyl compounds containing a single hydroxyl group." [ChEBI:30879, GOC:mah]
subset: gosubset_prok
synonym: "monohydric alcohol anabolism" EXACT []
synonym: "monohydric alcohol biosynthesis" EXACT []
synonym: "monohydric alcohol formation" EXACT []
synonym: "monohydric alcohol synthesis" EXACT []
is_a: GO:0034308 ! monohydric alcohol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0034310
name: monohydric alcohol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monohydric alcohols, any of a class of compounds containing a single hydroxyl group attached to a saturated carbon atom." [ChEBI:30879, GOC:mah]
subset: gosubset_prok
synonym: "monohydric alcohol breakdown" EXACT []
synonym: "monohydric alcohol catabolism" EXACT []
synonym: "monohydric alcohol degradation" EXACT []
is_a: GO:0034308 ! monohydric alcohol metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0034311
name: diol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [ChEBI:23824, GOC:mah]
subset: gosubset_prok
synonym: "dihydric alcohol metabolic process" EXACT []
synonym: "diol metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process

[Term]
id: GO:0034312
name: diol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [ChEBI:23824, GOC:mah]
synonym: "dihydric alcohol biosynthetic process" EXACT []
synonym: "diol anabolism" EXACT []
synonym: "diol biosynthesis" EXACT []
synonym: "diol formation" EXACT []
synonym: "diol synthesis" EXACT []
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0034313
name: diol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [ChEBI:23824, GOC:mah]
synonym: "dihydric alcohol catabolic process" EXACT []
synonym: "diol breakdown" EXACT []
synonym: "diol catabolism" EXACT []
synonym: "diol degradation" EXACT []
is_a: GO:0034311 ! diol metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0034314
name: Arp2/3 complex-mediated actin nucleation
namespace: biological_process
def: "The actin nucleation process by which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983]
synonym: "actin filament branch nucleation" EXACT []
synonym: "branched actin filament nucleation" EXACT []
is_a: GO:0045010 ! actin nucleation

[Term]
id: GO:0034315
name: regulation of Arp2/3 complex-mediated actin nucleation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah]
is_a: GO:0051125 ! regulation of actin nucleation
relationship: regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation

[Term]
id: GO:0034316
name: negative regulation of Arp2/3 complex-mediated actin nucleation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah, PMID:16959963]
is_a: GO:0034315 ! regulation of Arp2/3 complex-mediated actin nucleation
is_a: GO:0051126 ! negative regulation of actin nucleation
relationship: negatively_regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation

[Term]
id: GO:0034317
name: nicotinic acid riboside kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nicotinic acid riboside (NaR) = ADP + nicotinic acid mononucleotide (NaMN)." [PMID:17914902]
xref: MetaCyc:RXN-8443
is_a: GO:0019206 ! nucleoside kinase activity

[Term]
id: GO:0034318
name: alcohol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group to an oxygen atom on an alcohol acceptor molecule." [GOC:mah]
synonym: "acyl-CoA:alcohol O-acyltransferase activity" EXACT []
synonym: "acyl-CoA:ethanol O-acyltransferase" NARROW []
synonym: "acyl-coenzymeA:alcohol O-acyltransferase activity" EXACT []
synonym: "acyl-coenzymeA:ethanol O-acyltransferase activity" NARROW []
synonym: "AEATase activity" NARROW []
synonym: "alcohol acyltransferase activity" EXACT []
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0034319
name: alcohol O-butanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester." [GOC:mah, PMID:16361250]
is_a: GO:0016413 ! O-acetyltransferase activity
is_a: GO:0034318 ! alcohol O-acyltransferase activity
is_a: GO:0034323 ! O-butanoyltransferase activity

[Term]
id: GO:0034320
name: alcohol O-hexanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexanoyl-CoA + an alcohol = CoA + a hexyl ester." [GOC:mah, PMID:16361250]
is_a: GO:0016413 ! O-acetyltransferase activity
is_a: GO:0034318 ! alcohol O-acyltransferase activity
is_a: GO:0034324 ! O-hexanoyltransferase activity

[Term]
id: GO:0034321
name: alcohol O-octanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester." [GOC:mah, PMID:16361250]
is_a: GO:0016413 ! O-acetyltransferase activity
is_a: GO:0016414 ! O-octanoyltransferase activity
is_a: GO:0034318 ! alcohol O-acyltransferase activity

[Term]
id: GO:0034322
name: alcohol O-decanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: decanoyl-CoA + an alcohol = CoA + a decyl ester." [GOC:mah, PMID:16361250]
is_a: GO:0016413 ! O-acetyltransferase activity
is_a: GO:0034318 ! alcohol O-acyltransferase activity
is_a: GO:0034325 ! O-decanoyltransferase activity

[Term]
id: GO:0034323
name: O-butanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a butyl group to an oxygen atom on the acceptor molecule." [GOC:mah]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0034326 ! butanoyltransferase activity

[Term]
id: GO:0034324
name: O-hexanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hexyl group to an oxygen atom on the acceptor molecule." [GOC:mah]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0034327 ! hexanoyltransferase activity

[Term]
id: GO:0034325
name: O-decanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a decyl group to an oxygen atom on the acceptor molecule." [GOC:mah]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0034328 ! decanoyltransferase activity

[Term]
id: GO:0034326
name: butanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a butanoyl (CH3-[CH2]2-CO-) group to an acceptor molecule." [GOC:mah]
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0034327
name: hexanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hexanoyl (CH3-[CH2]4-CO-) group to an acceptor molecule." [GOC:mah]
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0034328
name: decanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a decanoyl (CH3-[CH2]8-CO-) group to an acceptor molecule." [GOC:mah]
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0034329
name: cell junction assembly
namespace: biological_process
def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0034330 ! cell junction organization

[Term]
id: GO:0034330
name: cell junction organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah]
synonym: "cell junction assembly and maintenance" EXACT []
synonym: "cell junction biogenesis" RELATED []
is_a: GO:0009987 ! cellular process
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0034331
name: cell junction maintenance
namespace: biological_process
def: "The organization process by which a cell junction is preserved in a stable functional or structural state. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0034330 ! cell junction organization
is_a: GO:0043954 ! cellular component maintenance

[Term]
id: GO:0034332
name: adherens junction organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:dph, GOC:jl, GOC:mah]
synonym: "adherens junction assembly and maintenance" EXACT []
synonym: "adherens junction organisation" EXACT [GOC:curators]
is_a: GO:0045216 ! cell-cell junction organization

[Term]
id: GO:0034333
name: adherens junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah]
synonym: "adherens junction formation" EXACT []
is_a: GO:0034329 ! cell junction assembly
is_a: GO:0034332 ! adherens junction organization

[Term]
id: GO:0034334
name: adherens junction maintenance
namespace: biological_process
def: "The maintenance of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:mah]
is_a: GO:0034331 ! cell junction maintenance
is_a: GO:0034332 ! adherens junction organization

[Term]
id: GO:0034335
name: DNA supercoiling activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the formation of positive or negative supercoils in a DNA molecule or region thereof; may be associated with a geometric or topological change in the DNA molecule." [GOC:mah]
comment: This term was made obsolete because, although it was requested, it is not needed after all; it was not defined clearly, and does not necessarily correspond to a catalytic activity.
is_obsolete: true
consider: GO:0015616
consider: GO:0032392

[Term]
id: GO:0034336
name: misfolded RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA molecule that has assumed an incorrect conformation." [GOC:mah, PMID:10393192]
synonym: "RNA chaperone" RELATED []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0034337
name: RNA folding
namespace: biological_process
def: "The process of assisting in the covalent and noncovalent assembly of single or multimeric RNAs into the correct tertiary structure." [GOC:mah, PMID:10393192]
synonym: "RNA chaperone" RELATED []
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0034338
name: short-chain carboxylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms." [GOC:jp]
subset: gosubset_prok
synonym: "butyrate esterase activity" NARROW []
synonym: "butyryl esterase activity" NARROW []
synonym: "methylbutyrase activity" NARROW []
synonym: "methylbutyrate esterase activity" NARROW []
synonym: "monobutyrase activity" NARROW []
synonym: "propionyl esterase activity" NARROW []
synonym: "short-chain esterase activity" BROAD []
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0034339
name: regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
namespace: biological_process
def: "Any process by which a ligand-bound hormone receptor acts in the nucleus to modulate the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GO_REF:0000021, GOC:mah, GOC:mh]
comment: This term was added by GO_REF:0000021.
xref: Reactome:383280 "Nuclear Receptor transcription pathway"
is_a: GO:0010551 ! regulation of gene-specific transcription from RNA polymerase II promoter

[Term]
id: GO:0034340
name: response to type I interferon
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834]
synonym: "response to type I IFN" EXACT []
is_a: GO:0034097 ! response to cytokine stimulus
relationship: part_of GO:0045087 ! innate immune response

[Term]
id: GO:0034341
name: response to interferon-gamma
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon." [GOC:add, ISBN:0126896631, PMID:15546383]
synonym: "response to gamma-interferon" RELATED []
synonym: "response to immune interferon" EXACT []
synonym: "response to type II IFN" EXACT []
synonym: "response to type II interferon" EXACT []
is_a: GO:0034097 ! response to cytokine stimulus
relationship: part_of GO:0045087 ! innate immune response

[Term]
id: GO:0034342
name: response to type III interferon
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
synonym: "response to interferon-lambda" EXACT []
synonym: "response to type III IFN" EXACT []
is_a: GO:0034097 ! response to cytokine stimulus
relationship: part_of GO:0045087 ! innate immune response

[Term]
id: GO:0034343
name: type III interferon production
namespace: biological_process
def: "The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "type III IFN production" EXACT []
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0034344
name: regulation of type III interferon production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of type III interferon production. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "regulation of type III IFN production" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0034343 ! type III interferon production

[Term]
id: GO:0034345
name: negative regulation of type III interferon production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type III interferon production. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "down regulation of type III interferon production" EXACT []
synonym: "down-regulation of type III interferon production" EXACT []
synonym: "downregulation of type III interferon production" EXACT []
synonym: "inhibition of type III interferon production" NARROW []
synonym: "negative regulation of type III IFN production" EXACT []
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0034344 ! regulation of type III interferon production
relationship: negatively_regulates GO:0034343 ! type III interferon production

[Term]
id: GO:0034346
name: positive regulation of type III interferon production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of type III interferon production. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "activation of type III interferon production" NARROW []
synonym: "positive regulation of type III IFN production" EXACT []
synonym: "stimulation of type III interferon production" NARROW []
synonym: "up regulation of type III interferon production" EXACT []
synonym: "up-regulation of type III interferon production" EXACT []
synonym: "upregulation of type III interferon production" EXACT []
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0034344 ! regulation of type III interferon production
relationship: positively_regulates GO:0034343 ! type III interferon production

[Term]
id: GO:0034347
name: type III interferon binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type III interferon. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "interferon-lambda binding" EXACT []
is_a: GO:0019961 ! interferon binding

[Term]
id: GO:0034348
name: type III interferon receptor activity
namespace: molecular_function
def: "Combining with a type III interferon to initiate a change in cell activity. Type III interferons are members of the interferon-lambda gene family." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557]
comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda.
synonym: "interferon-lambda receptor activity" EXACT []
is_a: GO:0004904 ! interferon receptor activity
is_a: GO:0034347 ! type III interferon binding

[Term]
id: GO:0034349
name: glial cell apoptosis
namespace: biological_process
def: "The process of apoptosis in glial cells." [GOC:sart]
synonym: "apoptosis of glia" EXACT []
synonym: "apoptosis of glial cells" EXACT []
synonym: "glia apoptosis" EXACT []
synonym: "glia programmed cell death by apoptosis" EXACT []
synonym: "glial cell programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of glia by apoptosis" EXACT []
synonym: "programmed cell death of glial cells by apoptosis" EXACT []
synonym: "programmed cell death, glia" EXACT []
synonym: "programmed cell death, glial cells" EXACT []
is_a: GO:0006915 ! apoptosis

[Term]
id: GO:0034350
name: regulation of glial cell apoptosis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of glial cell apoptosis." [GOC:mah]
is_a: GO:0042981 ! regulation of apoptosis
relationship: regulates GO:0034349 ! glial cell apoptosis

[Term]
id: GO:0034351
name: negative regulation of glial cell apoptosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptosis." [GOC:mah]
synonym: "down regulation of glial cell apoptosis" EXACT []
synonym: "down-regulation of glial cell apoptosis" EXACT []
synonym: "downregulation of glial cell apoptosis" EXACT []
synonym: "inhibition of glial cell apoptosis" NARROW []
is_a: GO:0034350 ! regulation of glial cell apoptosis
is_a: GO:0043066 ! negative regulation of apoptosis
relationship: negatively_regulates GO:0034349 ! glial cell apoptosis

[Term]
id: GO:0034352
name: positive regulation of glial cell apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of glial cell apoptosis." [GOC:mah]
synonym: "activation of glial cell apoptosis" NARROW []
synonym: "stimulation of glial cell apoptosis" NARROW []
synonym: "up regulation of glial cell apoptosis" EXACT []
synonym: "up-regulation of glial cell apoptosis" EXACT []
synonym: "upregulation of glial cell apoptosis" EXACT []
is_a: GO:0034350 ! regulation of glial cell apoptosis
is_a: GO:0043065 ! positive regulation of apoptosis
relationship: positively_regulates GO:0034349 ! glial cell apoptosis

[Term]
id: GO:0034353
name: RNA pyrophosphohydrolase activity
namespace: molecular_function
def: "Catalysis of the removal of a 5' terminal pyrophosphate from the 5'-triphosphate end of an RNA, leaving a 5'-monophosphate end." [GOC:jh2, PMID:17612492, PMID:18202662]
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0034354
name: de novo NAD biosynthetic process from tryptophan
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [PMID:17161604]
is_a: GO:0034627 ! de novo NAD biosynthetic process

[Term]
id: GO:0034355
name: NAD salvage
namespace: biological_process
def: "Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam)." [GOC:mah, PMID:12648681]
synonym: "NAD salvage pathway" EXACT []
is_a: GO:0009435 ! NAD biosynthetic process

[Term]
id: GO:0034356
name: NAD biosynthesis via nicotinamide riboside salvage pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside." [PMID:17482543]
synonym: "nicotinamide riboside salvage pathway" EXACT []
synonym: "NR salvage pathway" EXACT []
is_a: GO:0009435 ! NAD biosynthetic process

[Term]
id: GO:0034357
name: photosynthetic membrane
namespace: cellular_component
def: "A membrane enriched in complexes formed of reaction centers, accessory pigments and electron carriers, in which photosynthetic reactions take place." [GOC:ds, GOC:mah]
subset: gosubset_prok
is_a: GO:0016020 ! membrane
relationship: part_of GO:0009579 ! thylakoid

[Term]
id: GO:0034358
name: plasma lipoprotein particle
namespace: cellular_component
def: "A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph." [GOC:BHF, GOC:expert_pt, GOC:rl]
is_a: GO:0032994 ! protein-lipid complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0034359
name: mature chylomicron
namespace: cellular_component
def: "A chylomicron that contains apolipoprotein C2 (APOC2), a cofactor for lipoprotein lipase (LPL) activity, and has a mean diameter of 500 nm and density of 0.95g/ml. Mature chylomicron particles transport exogenous (dietary) lipids from the intestines to other body tissues, via the blood and lymph." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
is_a: GO:0042627 ! chylomicron

[Term]
id: GO:0034360
name: chylomicron remnant
namespace: cellular_component
def: "A lipoprotein particle that is derived from a mature chylomicron particle by the removal of triglycerides from the chylomicron core by lipoprotein lipase and the subsequent loss of surface components. It characteristically contains apolipoprotein E (APOE) and is cleared from the blood by the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
is_a: GO:0042627 ! chylomicron

[Term]
id: GO:0034361
name: very-low-density lipoprotein particle
namespace: cellular_component
def: "A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "very-low-density lipoprotein complex" EXACT []
synonym: "VLDL complex" EXACT []
synonym: "VLDL particle" EXACT []
is_a: GO:0034385 ! triglyceride-rich lipoprotein particle

[Term]
id: GO:0034362
name: low-density lipoprotein particle
namespace: cellular_component
def: "A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "LDL complex" EXACT []
synonym: "LDL particle" EXACT []
synonym: "low-density lipoprotein complex" EXACT []
is_a: GO:0034358 ! plasma lipoprotein particle

[Term]
id: GO:0034363
name: intermediate-density lipoprotein particle
namespace: cellular_component
def: "A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "IDL complex" EXACT []
synonym: "IDL particle" EXACT []
synonym: "intermediate-density lipoprotein complex" EXACT []
is_a: GO:0034385 ! triglyceride-rich lipoprotein particle

[Term]
id: GO:0034364
name: high-density lipoprotein particle
namespace: cellular_component
def: "A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:pd, GOC:rl]
synonym: "HDL complex" EXACT []
synonym: "HDL particle" EXACT []
synonym: "HDL2" RELATED []
synonym: "HDL3" RELATED []
synonym: "high-density lipoprotein class complex" EXACT []
is_a: GO:0034358 ! plasma lipoprotein particle

[Term]
id: GO:0034365
name: discoidal high-density lipoprotein particle
namespace: cellular_component
def: "A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "discoidal HDL" EXACT []
synonym: "nascent HDL" EXACT []
synonym: "nascent high-density lipoprotein particle" EXACT []
is_a: GO:0034364 ! high-density lipoprotein particle

[Term]
id: GO:0034366
name: spherical high-density lipoprotein particle
namespace: cellular_component
def: "A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "mature HDL" EXACT []
synonym: "mature high-density lipoprotein particle" EXACT []
synonym: "spherical HDL" EXACT []
is_a: GO:0034364 ! high-density lipoprotein particle

[Term]
id: GO:0034367
name: macromolecular complex remodeling
namespace: biological_process
def: "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex." [GOC:BHF, GOC:mah, GOC:mtg_mpo, GOC:rl]
is_a: GO:0043933 ! macromolecular complex subunit organization

[Term]
id: GO:0034368
name: protein-lipid complex remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a protein-lipid complex." [GOC:BHF, GOC:mah, GOC:rl]
is_a: GO:0034367 ! macromolecular complex remodeling

[Term]
id: GO:0034369
name: plasma lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
is_a: GO:0034368 ! protein-lipid complex remodeling

[Term]
id: GO:0034370
name: triglyceride-rich lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a triglyceride-rich lipoprotein particle, including the hydrolysis of triglyceride by lipoprotein lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride from a triglyceride-rich lipoprotein particle." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "triacylglycerol-rich lipoprotein particle remodeling" EXACT [GOC:mah]
is_a: GO:0034369 ! plasma lipoprotein particle remodeling

[Term]
id: GO:0034371
name: chylomicron remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "chylomicron remnant formation" RELATED []
is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling

[Term]
id: GO:0034372
name: very-low-density lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "IDL formation" RELATED []
synonym: "intermediate-density lipoprotein particle formation" RELATED []
synonym: "VLDL remodeling" EXACT []
is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling

[Term]
id: GO:0034373
name: intermediate-density lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within an intermediate-density lipoprotein particle." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "IDL remodeling" EXACT []
synonym: "LDL formation" RELATED []
synonym: "low-density lipoprotein particle formation" RELATED []
is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling

[Term]
id: GO:0034374
name: low-density lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "LDL remodeling" EXACT []
is_a: GO:0034369 ! plasma lipoprotein particle remodeling

[Term]
id: GO:0034375
name: high-density lipoprotein particle remodeling
namespace: biological_process
def: "The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl]
synonym: "HDL remodeling" EXACT []
is_a: GO:0034369 ! plasma lipoprotein particle remodeling

[Term]
id: GO:0034376
name: conversion of discoidal high-density lipoprotein to spherical high-density lipoprotein
namespace: biological_process
def: "The process by which a discoidal high-density lipoprotein (HDL) particle acquires additional lipid or protein molecules, and cholesterol in the particle is converted to tightly bound cholesterol esters by the action of phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT), resulting in the formation of a spherical HDL particle." [GOC:BHF, GOC:mah, GOC:pd]
synonym: "conversion of discoidal HDL to spherical HDL" EXACT []
synonym: "discoidal HDL remodeling" RELATED []
synonym: "discoidal high-density lipoprotein remodeling" RELATED []
is_a: GO:0034377 ! plasma lipoprotein particle assembly

[Term]
id: GO:0034377
name: plasma lipoprotein particle assembly
namespace: biological_process
def: "The aggregation and arrangement of proteins and lipids to form a plasma lipoprotein particle." [GOC:BHF, GOC:mah]
is_a: GO:0065005 ! protein-lipid complex assembly

[Term]
id: GO:0034378
name: chylomicron assembly
namespace: biological_process
def: "The aggregation and arrangement of proteins and lipids in the intestine to form a chylomicron." [GOC:BHF, GOC:mah]
is_a: GO:0034377 ! plasma lipoprotein particle assembly

[Term]
id: GO:0034379
name: very-low-density lipoprotein particle assembly
namespace: biological_process
def: "The aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle." [GOC:BHF, GOC:mah]
synonym: "VLDL assembly" EXACT []
is_a: GO:0034377 ! plasma lipoprotein particle assembly

[Term]
id: GO:0034380
name: high-density lipoprotein particle assembly
namespace: biological_process
def: "The aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:BHF, GOC:mah]
synonym: "HDL assembly" EXACT []
is_a: GO:0034377 ! plasma lipoprotein particle assembly

[Term]
id: GO:0034381
name: lipoprotein particle clearance
namespace: biological_process
def: "The process by which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0034382
name: chylomicron remnant clearance
namespace: biological_process
def: "The process by which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:BHF, GOC:mah, GOC:pd]
is_a: GO:0034381 ! lipoprotein particle clearance

[Term]
id: GO:0034383
name: low-density lipoprotein particle clearance
namespace: biological_process
def: "The process by which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:mah]
synonym: "LDL clearance" EXACT []
is_a: GO:0034381 ! lipoprotein particle clearance

[Term]
id: GO:0034384
name: high-density lipoprotein particle clearance
namespace: biological_process
def: "The process by which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:mah]
synonym: "HDL clearance" EXACT []
is_a: GO:0034381 ! lipoprotein particle clearance

[Term]
id: GO:0034385
name: triglyceride-rich lipoprotein particle
namespace: cellular_component
def: "A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoproteinparticles transport lipids, which are non-covalently associated with the particles, in the blood." [GOC:BHF, GOC:mah, GOC:rl]
synonym: "triacylglycerol-rich lipoprotein particle" EXACT [GOC:mah]
is_a: GO:0034358 ! plasma lipoprotein particle

[Term]
id: GO:0034386
name: 4-aminobutyrate:2-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate." [EC:2.6.1.19, GOC:mah]
synonym: "4-aminobutanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "4-aminobutyrate-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "4-aminobutyrate-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "4-aminobutyrate-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "4-aminobutyric acid 2-ketoglutaric acid aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "GABA-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "GABA-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "GABA-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "GABA-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "GABA-alpha-ketoglutaric acid transaminase activity" EXACT [EC:2.6.1.19]
synonym: "GABA-alpha-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "GABA-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "GABA-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyrate-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyrate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyrate:alpha-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyric acid-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyric acid-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.19]
synonym: "gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase activity" EXACT [EC:2.6.1.19]
xref: MetaCyc:GABATRANSAM-RXN
is_a: GO:0003867 ! 4-aminobutyrate transaminase activity

[Term]
id: GO:0034387
name: 4-aminobutyrate:pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine." [EC:2.6.1.19, GOC:mah]
synonym: "gamma-aminobutyric acid pyruvate transaminase activity" EXACT [EC:2.6.1.19]
xref: MetaCyc:RXN-6902
is_a: GO:0003867 ! 4-aminobutyrate transaminase activity

[Term]
id: GO:0034388
name: Pwp2p-containing subcomplex of 90S preribosome
namespace: cellular_component
def: "A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p." [GOC:krc, PMID:15231838]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
synonym: "25-30 S subcomplex of 90S preribosome" EXACT []
synonym: "UTP-B complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044452 ! nucleolar part
relationship: part_of GO:0030686 ! 90S preribosome

[Term]
id: GO:0034389
name: lipid particle organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201]
synonym: "adiposome organization" EXACT []
synonym: "lipid body organization" EXACT []
synonym: "lipid droplet organization" EXACT []
synonym: "lipid particle organisation" EXACT [GOC:curators]
synonym: "lipid particle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0034390
name: smooth muscle cell apoptosis
namespace: biological_process
def: "The process of apoptosis in smooth muscle cells. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels." [CL:0000192, GOC:BHF, GOC:mah, GOC:rl]
synonym: "apoptosis of smooth muscle cells" EXACT []
synonym: "programmed cell death of smooth muscle cells by apoptosis" EXACT []
synonym: "programmed cell death, smooth muscle cells" EXACT []
synonym: "SMC apoptosis" EXACT []
synonym: "smooth muscle cell programmed cell death by apoptosis" EXACT []
is_a: GO:0010657 ! muscle cell apoptosis

[Term]
id: GO:0034391
name: regulation of smooth muscle cell apoptosis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptosis." [GOC:BHF, GOC:rl]
synonym: "regulation of SMC apoptosis" EXACT []
is_a: GO:0010660 ! regulation of muscle cell apoptosis
relationship: regulates GO:0034390 ! smooth muscle cell apoptosis

[Term]
id: GO:0034392
name: negative regulation of smooth muscle cell apoptosis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptosis." [GOC:BHF, GOC:rl]
synonym: "down regulation of smooth muscle cell apoptosis" EXACT []
synonym: "down-regulation of smooth muscle cell apoptosis" EXACT []
synonym: "downregulation of smooth muscle cell apoptosis" EXACT []
synonym: "inhibition of smooth muscle cell apoptosis" NARROW []
synonym: "negative regulation of SMC apoptosis" EXACT []
is_a: GO:0010656 ! negative regulation of muscle cell apoptosis
is_a: GO:0034391 ! regulation of smooth muscle cell apoptosis
relationship: negatively_regulates GO:0034390 ! smooth muscle cell apoptosis

[Term]
id: GO:0034393
name: positive regulation of smooth muscle cell apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptosis." [GOC:BHF, GOC:rl]
synonym: "activation of smooth muscle cell apoptosis" NARROW []
synonym: "positive regulation of SMC apoptosis" EXACT []
synonym: "stimulation of smooth muscle cell apoptosis" NARROW []
synonym: "up regulation of smooth muscle cell apoptosis" EXACT []
synonym: "up-regulation of smooth muscle cell apoptosis" EXACT []
synonym: "upregulation of smooth muscle cell apoptosis" EXACT []
is_a: GO:0010661 ! positive regulation of muscle cell apoptosis
is_a: GO:0034391 ! regulation of smooth muscle cell apoptosis
relationship: positively_regulates GO:0034390 ! smooth muscle cell apoptosis

[Term]
id: GO:0034394
name: protein localization at cell surface
namespace: biological_process
def: "A process by which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane." [GOC:mah]
is_a: GO:0034613 ! cellular protein localization

[Term]
id: GO:0034395
name: regulation of transcription from RNA polymerase II promoter in response to iron
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GO_REF:0000021, GOC:mah]
comment: This term was added by GO_REF:0000021.
synonym: "regulation of specific transcription from RNA polymerase II promoter in response to iron" EXACT []
is_a: GO:0010551 ! regulation of gene-specific transcription from RNA polymerase II promoter
is_a: GO:0071281 ! cellular response to iron ion

[Term]
id: GO:0034396
name: negative regulation of transcription from RNA polymerase II promoter in response to iron
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GOC:mah]
synonym: "down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW []
synonym: "negative regulation of transcription from Pol II promoter in response to iron" EXACT []
is_a: GO:0010553 ! negative regulation of gene-specific transcription from RNA polymerase II promoter
is_a: GO:0034395 ! regulation of transcription from RNA polymerase II promoter in response to iron

[Term]
id: GO:0034397
name: telomere localization
namespace: biological_process
def: "Any process by which a telomere is transported to, and/or maintained in, a specific location." [GOC:mah]
is_a: GO:0051276 ! chromosome organization
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0034398
name: telomere tethering at nuclear periphery
namespace: biological_process
def: "The process by which a telomere is maintained in a specific location at the nuclear periphery." [GOC:mah]
is_a: GO:0034397 ! telomere localization

[Term]
id: GO:0034399
name: nuclear periphery
namespace: cellular_component
def: "The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah]
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031981 ! nuclear lumen

[Term]
id: GO:0034400
name: gerontoplast
namespace: cellular_component
def: "A plastid found in senescing, formerly green tissues that is derived from a chloroplast that undergoes an organized developmental program of senescence." [PMID:12654863, PMID:16151876]
is_a: GO:0009536 ! plastid

[Term]
id: GO:0034401
name: chromatin organization during transcription
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin during transcription." [GOC:curators]
synonym: "establishment or maintenance of chromatin architecture during transcription" EXACT [GOC:mah]
is_a: GO:0006325 ! chromatin organization

[Term]
id: GO:0034402
name: recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
namespace: biological_process
def: "The process by which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript." [PMID:18195044]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0031124 ! mRNA 3'-end processing

[Term]
id: GO:0034403
name: alignment of 3' and 5' splice sites of nuclear mRNA
namespace: biological_process
def: "Recognition of both the 5' and 3'-splice sites and positioning them in the correct alignment with respect to each other so that the second catalytic step of nuclear mRNA splicing can occur." [GOC:krc, PMID:9430647]
is_a: GO:0000389 ! nuclear mRNA 3'-splice site recognition
is_a: GO:0000395 ! nuclear mRNA 5'-splice site recognition
relationship: part_of GO:0000350 ! generation of catalytic spliceosome for second transesterification step

[Term]
id: GO:0034404
name: nucleobase, nucleoside and nucleotide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides and nucleotides." [GOC:mah]
synonym: "nucleobase, nucleoside and nucleotide anabolism" EXACT []
synonym: "nucleobase, nucleoside and nucleotide biosynthesis" EXACT []
synonym: "nucleobase, nucleoside and nucleotide formation" EXACT []
synonym: "nucleobase, nucleoside and nucleotide synthesis" EXACT []
is_a: GO:0034654 ! nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process

[Term]
id: GO:0034405
name: response to fluid shear stress
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface." [GOC:sl]
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0034406
name: cell wall beta-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
subset: gosubset_prok
synonym: "cell wall beta-glucan metabolism" EXACT []
is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process
is_a: GO:0010383 ! cell wall polysaccharide metabolic process
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0034407
name: cell wall 1,3-beta-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
subset: gosubset_prok
synonym: "cell wall 1,3-beta-glucan metabolism" EXACT []
synonym: "cell wall beta-1,3 glucan metabolic process" EXACT []
synonym: "cell wall beta-1,3 glucan metabolism" EXACT []
is_a: GO:0006074 ! 1,3-beta-glucan metabolic process
is_a: GO:0034406 ! cell wall beta-glucan metabolic process

[Term]
id: GO:0034408
name: ascospore wall beta-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall beta-glucan metabolism" EXACT []
is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process
relationship: part_of GO:0070591 ! ascospore wall biogenesis

[Term]
id: GO:0034409
name: ascospore wall 1,3-beta-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall 1,3-beta-glucan metabolism" EXACT [GOC:mah]
synonym: "ascospore wall beta-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "ascospore wall beta-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0034407 ! cell wall 1,3-beta-glucan metabolic process
is_a: GO:0034408 ! ascospore wall beta-glucan metabolic process

[Term]
id: GO:0034410
name: cell wall beta-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
subset: gosubset_prok
synonym: "cell wall beta-glucan anabolism" EXACT []
synonym: "cell wall beta-glucan biosynthesis" EXACT []
synonym: "cell wall beta-glucan formation" EXACT []
synonym: "cell wall beta-glucan synthesis" EXACT []
is_a: GO:0034406 ! cell wall beta-glucan metabolic process
is_a: GO:0051274 ! beta-glucan biosynthetic process
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process

[Term]
id: GO:0034411
name: cell wall 1,3-beta-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1,3-beta-glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "cell wall 1,3-beta-glucan anabolism" EXACT []
synonym: "cell wall 1,3-beta-glucan biosynthesis" EXACT []
synonym: "cell wall 1,3-beta-glucan formation" EXACT []
synonym: "cell wall 1,3-beta-glucan synthesis" EXACT []
synonym: "cell wall beta-1,3-glucan anabolism" EXACT []
synonym: "cell wall beta-1,3-glucan biosynthesis" EXACT []
synonym: "cell wall beta-1,3-glucan biosynthetic process" EXACT []
synonym: "cell wall beta-1,3-glucan formation" EXACT []
synonym: "cell wall beta-1,3-glucan synthesis" EXACT []
is_a: GO:0006075 ! 1,3-beta-glucan biosynthetic process
is_a: GO:0034407 ! cell wall 1,3-beta-glucan metabolic process
is_a: GO:0034410 ! cell wall beta-glucan biosynthetic process
is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process

[Term]
id: GO:0034412
name: ascospore wall beta-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall beta-glucan anabolism" EXACT []
synonym: "ascospore wall beta-glucan biosynthesis" EXACT []
synonym: "ascospore wall beta-glucan formation" EXACT []
synonym: "ascospore wall beta-glucan synthesis" EXACT []
is_a: GO:0034408 ! ascospore wall beta-glucan metabolic process
is_a: GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process

[Term]
id: GO:0034413
name: ascospore wall 1,3-beta-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1,3-beta-glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall 1,3-beta-glucan anabolism" EXACT []
synonym: "ascospore wall 1,3-beta-glucan biosynthesis" EXACT []
synonym: "ascospore wall 1,3-beta-glucan formation" EXACT []
synonym: "ascospore wall 1,3-beta-glucan synthesis" EXACT []
synonym: "ascospore wall beta-1,3-glucan anabolism" EXACT []
synonym: "ascospore wall beta-1,3-glucan biosynthesis" EXACT []
synonym: "ascospore wall beta-1,3-glucan biosynthetic process" EXACT []
synonym: "ascospore wall beta-1,3-glucan formation" EXACT []
synonym: "ascospore wall beta-1,3-glucan synthesis" EXACT []
is_a: GO:0034409 ! ascospore wall 1,3-beta-glucan metabolic process
is_a: GO:0034411 ! cell wall 1,3-beta-glucan biosynthetic process
is_a: GO:0034412 ! ascospore wall beta-glucan biosynthetic process

[Term]
id: GO:0034414
name: tRNA 3'-trailer cleavage, endonucleolytic
namespace: biological_process
def: "Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA." [GOC:mah]
synonym: "endonucleolytic tRNA 3'-end cleavage" EXACT []
synonym: "endonucleolytic tRNA 3'-trailer cleavage" RELATED []
synonym: "tRNA 3'-end cleavage, endonucleolytic" EXACT []
is_a: GO:0042779 ! tRNA 3'-trailer cleavage

[Term]
id: GO:0034415
name: tRNA 3'-trailer cleavage, exonucleolytic
namespace: biological_process
def: "Exonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA." [GOC:mah]
synonym: "exonucleolytic tRNA 3'-end cleavage" EXACT []
synonym: "exonucleolytic tRNA 3'-trailer cleavage" EXACT []
synonym: "tRNA 3'-end cleavage, exonucleolytic" EXACT []
is_a: GO:0042779 ! tRNA 3'-trailer cleavage

[Term]
id: GO:0034416
name: bisphosphoglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = phosphoglycerate + phosphate." [EC:3.1.3.13, GOC:mah, PMID:18413611]
synonym: "2,3-bisphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.13]
synonym: "2,3-diphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.13]
synonym: "2,3-diphosphoglyceric acid phosphatase activity" EXACT [EC:3.1.3.13]
synonym: "diphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.13]
synonym: "glycerate-2,3-diphosphate phosphatase activity" EXACT [EC:3.1.3.13]
xref: MetaCyc:BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0034417
name: bisphosphoglycerate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phosphoglycerate + phosphate." [EC:3.1.3.13, GOC:mah, PMID:18413611]
synonym: "2,3-bisphospho-D-glycerate 3-phosphohydrolase activity" EXACT [EC:3.1.3.13]
is_a: GO:0034416 ! bisphosphoglycerate phosphatase activity

[Term]
id: GO:0034418
name: urate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of urate, the anion of uric acid, 2,6,8-trioxypurine." [GOC:mah]
synonym: "urate anabolism" RELATED []
synonym: "urate biosynthesis" EXACT []
synonym: "urate formation" EXACT []
synonym: "urate synthesis" EXACT []
synonym: "uric acid biosynthetic process" EXACT []
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:0046415 ! urate metabolic process

[Term]
id: GO:0034419
name: L-2-hydroxyglutarate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-hydroxyglutarate + O2 = 2-oxoglutarate + H2O2." [PMID:18390652]
is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity

[Term]
id: GO:0034420
name: co-translational protein amino acid acetylation
namespace: biological_process
def: "The addition of an acetyl group to one or more amino acids in a protein, occurring before the protein has been completely translated and released from the ribosome." [GOC:mah]
synonym: "cotranslational protein amino acid acetylation" EXACT []
is_a: GO:0006473 ! protein amino acid acetylation
is_a: GO:0043686 ! co-translational protein modification

[Term]
id: GO:0034421
name: post-translational protein amino acid acetylation
namespace: biological_process
def: "The addition of an acetyl group to one or more amino acids in a protein, occurring after the protein has been completely translated and released from the ribosome." [GOC:mah]
synonym: "posttranslational protein amino acid acetylation" EXACT []
is_a: GO:0006473 ! protein amino acid acetylation

[Term]
id: GO:0034422
name: aleurone grain lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an aleurone grain." [GOC:rph]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0033095 ! aleurone grain

[Term]
id: GO:0034423
name: autophagic vacuole lumen
namespace: cellular_component
def: "The volume enclosed within the autophagic vacuole membrane." [GOC:rph]
comment: Note that this term should be used for annotating gene products with caution: it should be used only to annotate gene products demonstrated to reside and function normally in the autophagic vacuole lumen, not for molecules that are temporarily found in the lumen prior to degradation.
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0005776 ! autophagic vacuole

[Term]
id: GO:0034424
name: Vps55/Vps68 complex
namespace: cellular_component
def: "A membrane-associated protein complex that is required for a late stage of endosomal transport. In budding yeast, this complex consists of Vps55p and Vps68p proteins." [PMID:18216282]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044440 ! endosomal part
relationship: part_of GO:0010008 ! endosome membrane

[Term]
id: GO:0034425
name: etioplast envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the etioplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah]
is_a: GO:0009526 ! plastid envelope
relationship: part_of GO:0009513 ! etioplast

[Term]
id: GO:0034426
name: etioplast membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a etioplast and form the etioplast envelope." [GOC:rph]
is_a: GO:0042170 ! plastid membrane
relationship: part_of GO:0034425 ! etioplast envelope

[Term]
id: GO:0034427
name: nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [GOC:krc, GOC:mah]
synonym: "3'-5' exonucleolytic nuclear-transcribed mRNA catabolic process" EXACT []
is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic

[Term]
id: GO:0034428
name: nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3'
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction." [GOC:krc, GOC:mah]
synonym: "5'-3' exonucleolytic nuclear-transcribed mRNA catabolic process" EXACT []
is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic

[Term]
id: GO:0034429
name: tectobulbar tract morphogenesis
namespace: biological_process
def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the optic tectum towards target cells in the premotor reticulospinal system in the hindbrain." [GOC:dsf, PMID:15065115, PMID:17507550, PMID:8038988]
is_a: GO:0021952 ! central nervous system projection neuron axonogenesis

[Term]
id: GO:0034430
name: monolayer-surrounded lipid storage body outer lipid monolayer
namespace: cellular_component
def: "The single layer of phopholipids surrounding a lipid storage body." [GOC:rph]
synonym: "lipid droplet outer lipid monolayer" RELATED []
synonym: "lipid storage body surface lipid monolayer" EXACT []
synonym: "oil body outer lipid monolayer" EXACT []
synonym: "oleosome outer lipid monolayer" EXACT []
synonym: "spherosome outer lipid monolayer" EXACT []
is_a: GO:0034646 ! organelle-enclosing lipid monolayer
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0012511 ! monolayer-surrounded lipid storage body

[Term]
id: GO:0034431
name: bis(5'-adenosyl)-hexaphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate." [PMID:10085096, PMID:9450008]
synonym: "AP(6)A hydrolase activity" EXACT []
synonym: "AP-6-A hydrolase activity" EXACT []
synonym: "AP6A hydrolase activity" EXACT []
synonym: "diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase activity" EXACT []
is_a: GO:0004551 ! nucleotide diphosphatase activity

[Term]
id: GO:0034432
name: bis(5'-adenosyl)-pentaphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate." [PMID:10085096, PMID:9450008]
synonym: "AP(5)A hydrolase activity" EXACT []
synonym: "AP-5-A hydrolase activity" EXACT []
synonym: "AP5A hydrolase activity" EXACT []
synonym: "Ap5a pyrophosphohydrolase activity" EXACT [GOC:tb]
synonym: "diadenosine 5',5'''-P1,P6-pentaphosphate hydrolase activity" EXACT []
is_a: GO:0004551 ! nucleotide diphosphatase activity

[Term]
id: GO:0034433
name: steroid esterification
namespace: biological_process
def: "A lipid modification process in which a steroid ester is formed by the combination of a carboxylic acid (often a fatty acid) and a steroid molecule (e.g. cholesterol)." [GOC:BHF, GOC:mah, GOC:pd, GOC:rl]
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0034434
name: sterol esterification
namespace: biological_process
def: "A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and a sterol molecule (e.g. cholesterol)." [GOC:BHF, GOC:mah, GOC:pd, GOC:rl]
is_a: GO:0034433 ! steroid esterification

[Term]
id: GO:0034435
name: cholesterol esterification
namespace: biological_process
def: "A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:BHF, GOC:mah, GOC:pd, GOC:rl]
is_a: GO:0034434 ! sterol esterification

[Term]
id: GO:0034436
name: glycoprotein transport
namespace: biological_process
def: "The directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:BHF, GOC:mah, GOC:rl]
is_a: GO:0015031 ! protein transport

[Term]
id: GO:0034437
name: glycoprotein transporter activity
namespace: molecular_function
def: "Enables the directed movement of a glycoprotein, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid, into, out of, within or between cells." [GOC:BHF, GOC:mah, GOC:rl]
is_a: GO:0008565 ! protein transporter activity

[Term]
id: GO:0034438
name: lipoprotein amino acid oxidation
namespace: biological_process
def: "The modification of a lipoprotein by oxidation of one or more amino acids in the protein." [GOC:BHF, GOC:mah]
subset: gosubset_prok
is_a: GO:0018158 ! protein amino acid oxidation
is_a: GO:0042161 ! lipoprotein oxidation

[Term]
id: GO:0034439
name: lipoprotein lipid oxidation
namespace: biological_process
def: "The modification of a lipoprotein by oxidation of the lipid moiety." [GOC:BHF, GOC:mah]
subset: gosubset_prok
is_a: GO:0034440 ! lipid oxidation
is_a: GO:0042161 ! lipoprotein oxidation

[Term]
id: GO:0034440
name: lipid oxidation
namespace: biological_process
def: "The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [GOC:BHF, GOC:mah]
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0034441
name: plasma lipoprotein oxidation
namespace: biological_process
def: "The modification of a lipoprotein by oxidation of one or more amino acids or the lipid moiety, occurring in the blood plasma." [GOC:BHF, GOC:mah]
is_a: GO:0042161 ! lipoprotein oxidation

[Term]
id: GO:0034442
name: regulation of lipoprotein oxidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipoprotein oxidation." [GOC:BHF, GOC:mah]
is_a: GO:0050746 ! regulation of lipoprotein metabolic process
relationship: regulates GO:0042161 ! lipoprotein oxidation

[Term]
id: GO:0034443
name: negative regulation of lipoprotein oxidation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation." [GOC:BHF, GOC:mah]
synonym: "inhibition of lipoprotein oxidation" NARROW []
is_a: GO:0034442 ! regulation of lipoprotein oxidation
is_a: GO:0050748 ! negative regulation of lipoprotein metabolic process
relationship: negatively_regulates GO:0042161 ! lipoprotein oxidation

[Term]
id: GO:0034444
name: regulation of plasma lipoprotein oxidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipoprotein oxidation, occurring in the blood plasma." [GOC:BHF, GOC:mah]
is_a: GO:0034442 ! regulation of lipoprotein oxidation
relationship: regulates GO:0034441 ! plasma lipoprotein oxidation

[Term]
id: GO:0034445
name: negative regulation of plasma lipoprotein oxidation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation, occurring in the blood plasma." [GOC:BHF, GOC:mah]
synonym: "inhibition of plasma lipoprotein oxidation" NARROW []
is_a: GO:0034443 ! negative regulation of lipoprotein oxidation
is_a: GO:0034444 ! regulation of plasma lipoprotein oxidation
relationship: negatively_regulates GO:0034441 ! plasma lipoprotein oxidation

[Term]
id: GO:0034446
name: substrate adhesion-dependent cell spreading
namespace: biological_process
def: "The morphogenetic process by which flattening of a cell takes place as a consequence of its adhesion to a substrate." [GOC:mah, GOC:pf, PMID:17050732]
synonym: "cell spreading during cell substrate adhesion" EXACT []
synonym: "substrate adhesion dependent cell spreading" EXACT []
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
is_a: GO:0031589 ! cell-substrate adhesion

[Term]
id: GO:0034447
name: very-low-density lipoprotein particle clearance
namespace: biological_process
def: "The process by which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:rl]
synonym: "VLDL clearance" EXACT []
is_a: GO:0034381 ! lipoprotein particle clearance

[Term]
id: GO:0034448
name: EGO complex
namespace: cellular_component
def: "A vacuolar membrane-associated protein complex that is required for activation of microautophagy during exit from rapamycin-induced growth arrest. In budding yeast, S. cerevisiae, this complex includes Meh1p, Gtr2p and Slm4p." [GOC:rb, PMID:15989961]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0034449
name: GSE complex
namespace: cellular_component
def: "A conserved protein complex required for protein sorting from endosome to the plasma membrane. In budding yeast, S. cerevisiae, this complex includes Gtr1p, Gtr2p, Slm4p, Meh1p and Ltv1p and it sorts Gap1p." [GOC:rb, PMID:15989961]
synonym: "GTPase-containing complex for Gap1p sorting in the endosome" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044440 ! endosomal part

[Term]
id: GO:0034450
name: ubiquitin-ubiquitin ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: Catalysis of the reaction: ATP + ubiquitin + protein N-ubiquityl(n)lysine = AMP + diphosphate + protein N-ubiquityl(n+1)lysine, i.e. the ligation of ubiquitin moieties, via isopeptide bonds, to extend the length of the multiubiquitin chain attached to a substrate protein." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]
synonym: "E4" EXACT []
is_a: GO:0004842 ! ubiquitin-protein ligase activity

[Term]
id: GO:0034451
name: centriolar satellite
namespace: cellular_component
def: "A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome." [GOC:BHF, PMID:10579718, PMID:12403812]
is_a: GO:0044450 ! microtubule organizing center part
relationship: part_of GO:0005813 ! centrosome

[Term]
id: GO:0034452
name: dynactin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of a dynactin complex; dynactin is a large protein complex that activates dynein-based motor activity." [GOC:BHF, GOC:mah]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0034453
name: microtubule anchoring
namespace: biological_process
def: "Any process by which a microtubule is maintained in a specific location in a cell." [GOC:mah]
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0032507 ! maintenance of protein location in cell

[Term]
id: GO:0034454
name: microtubule anchoring at centrosome
namespace: biological_process
def: "Any process by which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah]
is_a: GO:0034453 ! microtubule anchoring

[Term]
id: GO:0034455
name: t-UTP complex
namespace: cellular_component
def: "A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p." [GOC:mah, PMID:17515605]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
synonym: "Nan1p-containing subcomplex of 90S preribosome" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044452 ! nucleolar part
relationship: part_of GO:0030686 ! 90S preribosome

[Term]
id: GO:0034456
name: UTP-C complex
namespace: cellular_component
def: "A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p." [GOC:mah, PMID:17515605]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
synonym: "Rrp7p-containing subcomplex of 90S preribosome" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044452 ! nucleolar part
relationship: part_of GO:0030686 ! 90S preribosome

[Term]
id: GO:0034457
name: Mpp10 complex
namespace: cellular_component
def: "A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p." [GOC:mah, PMID:17515605]
comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found.
is_a: GO:0043234 ! protein complex
is_a: GO:0044452 ! nucleolar part
relationship: part_of GO:0030686 ! 90S preribosome

[Term]
id: GO:0034458
name: 3'-5' RNA helicase activity
namespace: molecular_function
def: "Catalysis of the unwinding of an RNA helix in the direction 3' to 5'." [GOC:mah]
synonym: "3' to 5' RNA helicase activity" EXACT []
is_a: GO:0003724 ! RNA helicase activity

[Term]
id: GO:0034459
name: ATP-dependent 3'-5' RNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of an RNA helix in the direction 3' to 5'." [GOC:jp]
synonym: "ATP-dependent 3' to 5' RNA helicase activity" EXACT []
is_a: GO:0004004 ! ATP-dependent RNA helicase activity
is_a: GO:0034458 ! 3'-5' RNA helicase activity

[Term]
id: GO:0034460
name: uropod assembly
namespace: biological_process
def: "The assembly of a uropod by rearrangement of the cytoskeleton and overlying membrane." [GOC:mah]
synonym: "uropod formation" EXACT [GOC:mah]
is_a: GO:0030031 ! cell projection assembly
is_a: GO:0032796 ! uropod organization

[Term]
id: GO:0034461
name: uropod retraction
namespace: biological_process
def: "The process by which a uropod detaches from the cell substrate and retracts the rear of a migrating cell." [GOC:mah, PMID:10704379]
is_a: GO:0032796 ! uropod organization

[Term]
id: GO:0034462
name: small-subunit processome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome." [GOC:mah]
synonym: "small subunit processome assembly" EXACT []
synonym: "SSU processome assembly" EXACT []
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000028 ! ribosomal small subunit assembly

[Term]
id: GO:0034463
name: 90S preribosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a 90S preribosome." [GOC:mah]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0000027 ! ribosomal large subunit assembly
relationship: part_of GO:0000028 ! ribosomal small subunit assembly

[Term]
id: GO:0034464
name: BBSome
namespace: cellular_component
def: "A protein complex that associates with the primary cilium and is involved in cilium biogenesis; consists of seven conserved proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9." [GOC:BHF, PMID:17574030]
synonym: "Bardet-Biedl syndrome complex" EXACT []
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0034465
name: response to carbon monoxide
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:ecd]
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0034466
name: chromaffin granule lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a chromaffin granule." [GOC:rph]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0042583 ! chromaffin granule

[Term]
id: GO:0034467
name: esterosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an esterosome." [GOC:rph]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0033117 ! esterosome

[Term]
id: GO:0034468
name: glycosome lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a glycosome." [GOC:rph]
is_a: GO:0005782 ! peroxisomal matrix
relationship: part_of GO:0020015 ! glycosome

[Term]
id: GO:0034469
name: Golgi stack lumen
namespace: cellular_component
def: "The volume enclosed by any of the membranes of the thin, flattened cisternae that form the central portion of the Golgi complex." [GOC:mah]
is_a: GO:0005796 ! Golgi lumen
relationship: part_of GO:0005795 ! Golgi stack

[Term]
id: GO:0034470
name: ncRNA processing
namespace: biological_process
def: "Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules." [GOC:mah]
is_a: GO:0006396 ! RNA processing

[Term]
id: GO:0034471
name: ncRNA 5'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 5' end of a non-coding RNA molecule." [GOC:mah]
synonym: "ncRNA 5' end processing" EXACT []
is_a: GO:0000966 ! RNA 5'-end processing
is_a: GO:0034470 ! ncRNA processing

[Term]
id: GO:0034472
name: snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah]
synonym: "snRNA 3' end processing" EXACT []
is_a: GO:0016180 ! snRNA processing
is_a: GO:0043628 ! ncRNA 3'-end processing

[Term]
id: GO:0034473
name: U1 snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a U1 snRNA molecule." [GOC:mah]
synonym: "U1 snRNA 3' end processing" EXACT []
is_a: GO:0034472 ! snRNA 3'-end processing

[Term]
id: GO:0034474
name: U2 snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a U2 snRNA molecule." [GOC:mah]
synonym: "U2 snRNA 3' end processing" EXACT []
is_a: GO:0034472 ! snRNA 3'-end processing

[Term]
id: GO:0034475
name: U4 snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a U4 snRNA molecule." [GOC:mah]
synonym: "U4 snRNA 3' end processing" EXACT []
is_a: GO:0034472 ! snRNA 3'-end processing

[Term]
id: GO:0034476
name: U5 snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a U5 snRNA molecule." [GOC:mah]
synonym: "U5 snRNA 3' end processing" EXACT []
is_a: GO:0034472 ! snRNA 3'-end processing

[Term]
id: GO:0034477
name: U6 snRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a U6 snRNA molecule." [GOC:mah]
synonym: "U6 snRNA 3' end processing" EXACT []
is_a: GO:0034472 ! snRNA 3'-end processing

[Term]
id: GO:0034478
name: phosphatidylglycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [GOC:mah]
subset: gosubset_prok
synonym: "phosphatidylglycerol breakdown" EXACT []
synonym: "phosphatidylglycerol catabolism" EXACT []
synonym: "phosphatidylglycerol degradation" EXACT []
is_a: GO:0046471 ! phosphatidylglycerol metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process

[Term]
id: GO:0034479
name: phosphatidylglycerol phospholipase C activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate." [GOC:mah, PMID:18434318]
is_a: GO:0004629 ! phospholipase C activity

[Term]
id: GO:0034480
name: phosphatidylcholine phospholipase C activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1,2-diacylglycerol + a choline phosphate." [EC:3.1.4.3, GOC:mah]
subset: gosubset_prok
synonym: "alpha-toxin" NARROW [EC:3.1.4.3]
synonym: "Clostridium oedematiens beta- and gamma-toxins activity" NARROW [EC:3.1.4.3]
synonym: "Clostridium welchii alpha-toxin activity" NARROW [EC:3.1.4.3]
synonym: "heat-labile hemolysin" NARROW [EC:3.1.4.3]
synonym: "lipophosphodiesterase I activity" EXACT [EC:3.1.4.3]
synonym: "phosphatidylcholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.3]
synonym: "phospholipase C, acting on phosphatidylcholine" EXACT []
xref: EC:3.1.4.3
xref: MetaCyc:PHOSPHOLIPASE-C-RXN
is_a: GO:0004629 ! phospholipase C activity

[Term]
id: GO:0034481
name: chondroitin sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate." [EC:2.8.2.17, EC:2.8.2.5, GOC:mah]
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0034482
name: chondroitin 2-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 2'-O-sulfate. Results in sulfation of glucuronic acid and iduronic acid residues." [PMID:17227754]
synonym: "chondroitin 2-O-sulphotransferase activity" EXACT []
synonym: "chondroitin 2-sulfotransferase activity" EXACT []
is_a: GO:0034481 ! chondroitin sulfotransferase activity

[Term]
id: GO:0034483
name: heparan sulfate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate." [GOC:mah]
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0034484
name: raffinose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [ChEBI:16634, GOC:mah]
synonym: "raffinose breakdown" EXACT []
synonym: "raffinose catabolism" EXACT []
synonym: "raffinose degradation" EXACT []
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:0033530 ! raffinose metabolic process

[Term]
id: GO:0034485
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol 3,4,5-trisphosphate + H2O = phosphatidylinositol 3,4-bisphosphate + phosphate." [GOC:pf]
xref: MetaCyc:RXN-10036
is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity
is_a: GO:0034595 ! phosphoinositide 5-phosphatase activity

[Term]
id: GO:0034486
name: vacuolar transmembrane transport
namespace: biological_process
def: "The process whereby a solute is transported from one side of the vacuolar membrane to the other." [GOC:mah]
is_a: GO:0007034 ! vacuolar transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0034487
name: vacuolar amino acid transport
namespace: biological_process
def: "The process whereby an amino acid is transported from one side of the vacuolar membrane to the other." [GOC:mah]
synonym: "vacuolar amino acid transmembrane transport" EXACT []
is_a: GO:0006865 ! amino acid transport
is_a: GO:0034486 ! vacuolar transmembrane transport

[Term]
id: GO:0034488
name: basic amino acid export from vacuole
namespace: biological_process
def: "The directed movement of basic amino acids out of the vacuole." [GOC:mah]
is_a: GO:0015802 ! basic amino acid transport
is_a: GO:0032974 ! amino acid export from vacuole

[Term]
id: GO:0034489
name: neutral amino acid export from vacuole
namespace: biological_process
def: "The directed movement of neutral amino acids out of the vacuole." [GOC:mah]
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0032974 ! amino acid export from vacuole

[Term]
id: GO:0034490
name: basic amino acid import into vacuole
namespace: biological_process
def: "The directed movement of basic amino acids into the vacuole." [GOC:mah]
is_a: GO:0015802 ! basic amino acid transport
is_a: GO:0032975 ! amino acid import into vacuole

[Term]
id: GO:0034491
name: neutral amino acid import into vacuole
namespace: biological_process
def: "The directed movement of neutral amino acids into the vacuole." [GOC:mah]
is_a: GO:0015804 ! neutral amino acid transport
is_a: GO:0032975 ! amino acid import into vacuole

[Term]
id: GO:0034492
name: hydrogenosome lumen
namespace: cellular_component
def: "The volume enclosed by the hydrogenosome membrane." [GOC:rph]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0042566 ! hydrogenosome

[Term]
id: GO:0034493
name: melanosome lumen
namespace: cellular_component
def: "The volume enclosed by the melanosome membrane." [GOC:rph]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0042470 ! melanosome

[Term]
id: GO:0034494
name: microneme lumen
namespace: cellular_component
def: "The volume enclosed by the microneme membrane." [GOC:rph]
is_a: GO:0070013 ! intracellular organelle lumen
relationship: part_of GO:0020009 ! microneme

[Term]
id: GO:0034495
name: protein storage vacuole lumen
namespace: cellular_component
def: "The volume enclosed by the protein storage vacuole membrane." [GOC:rph]
is_a: GO:0000330 ! plant-type vacuole lumen
relationship: part_of GO:0000326 ! protein storage vacuole

[Term]
id: GO:0034496
name: multivesicular body membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the membranes of multivesicular bodies." [GOC:rb]
synonym: "MVB membrane disassembly" EXACT []
is_a: GO:0030397 ! membrane disassembly

[Term]
id: GO:0034497
name: protein localization to pre-autophagosomal structure
namespace: biological_process
def: "Any process by which a protein is transported to, or maintained at, the pre-autophagosomal structure (PAS)." [GOC:rb]
synonym: "protein localization to PAS" EXACT []
is_a: GO:0034613 ! cellular protein localization

[Term]
id: GO:0034498
name: early endosome to Golgi transport
namespace: biological_process
def: "The directed movement of substances from early endosomes to the Golgi." [GOC:rb]
synonym: "PGE to Golgi transport" EXACT []
synonym: "post-Golgi endosome to Golgi transport" EXACT []
is_a: GO:0042147 ! retrograde transport, endosome to Golgi
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0034499
name: late endosome to Golgi transport
namespace: biological_process
def: "The directed movement of substances from late endosomes to the Golgi." [GOC:rb]
synonym: "prevacuolar endosome to Golgi transport" EXACT []
synonym: "PVE to Golgi transport" EXACT []
is_a: GO:0042147 ! retrograde transport, endosome to Golgi
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0034500
name: rDNA separation
namespace: biological_process
def: "The cell cycle process whereby rDNA repeat regions are physically detached from each other during chromosome separation." [GOC:mah]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051304 ! chromosome separation

[Term]
id: GO:0034501
name: protein localization to kinetochore
namespace: biological_process
def: "Any process by which a protein is transported to, or maintained at, the kinetochore." [GOC:mah]
synonym: "condensin localization to kinetochore" NARROW []
is_a: GO:0034613 ! cellular protein localization

[Term]
id: GO:0034502
name: protein localization to chromosome
namespace: biological_process
def: "Any process by which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah]
synonym: "condensin localization to chromosome" NARROW []
is_a: GO:0034613 ! cellular protein localization

[Term]
id: GO:0034503
name: protein localization to nucleolar rDNA repeats
namespace: biological_process
def: "Any process by which a protein is transported to, or maintained at, the rDNA repeats on a chromosome in the nucleolus." [GOC:mah]
synonym: "condensin localization to nucleolar rDNA repeats" NARROW []
is_a: GO:0034502 ! protein localization to chromosome

[Term]
id: GO:0034504
name: protein localization in nucleus
namespace: biological_process
def: "A process by which a protein is transported to, or maintained in, a location within the nucleus." [GOC:ecd]
synonym: "protein localization in cell nucleus" EXACT []
synonym: "protein localization to nucleus" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization in organelle

[Term]
id: GO:0034505
name: tooth mineralization
namespace: biological_process
def: "The process by which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentine and cementum." [GOC:mah, MESH:tooth+calcification, MP:0002817]
synonym: "tooth calcification" EXACT []
is_a: GO:0031214 ! biomineral formation
relationship: part_of GO:0042476 ! odontogenesis

[Term]
id: GO:0034506
name: chromosome, centromeric core region
namespace: cellular_component
def: "The innermost portion of the centromeric region of a chromosome, encompassing the core region of a chromosome centromere and the proteins that bind to it." [GOC:mah, GOC:val]
synonym: "chromosome, centric core region" RELATED []
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000775 ! chromosome, centromeric region

[Term]
id: GO:0034507
name: chromosome, centromeric outer repeat region
namespace: cellular_component
def: "The portion of the centromeric region of a chromosome that flanks the core region, encompassing repeated regions of a chromosome centromere and the proteins that bind to it." [GOC:mah, GOC:val]
synonym: "chromosome, centric outer repeat region" RELATED []
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000775 ! chromosome, centromeric region

[Term]
id: GO:0034508
name: centromere complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw]
synonym: "centromere assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051276 ! chromosome organization
is_a: GO:0065004 ! protein-DNA complex assembly

[Term]
id: GO:0034509
name: centromeric core chromatin assembly
namespace: biological_process
def: "The assembly of chromatin into the specialized structure characteristic of the centromeric core region, defined by the presence of the variant histone CENP-A." [GOC:mah, GOC:vw]
synonym: "centric core chromatin formation" RELATED []
synonym: "centromere loading" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "centromeric core chromatin assembly" EXACT []
is_a: GO:0031497 ! chromatin assembly
relationship: part_of GO:0034508 ! centromere complex assembly

[Term]
id: GO:0034510
name: centromere separation
namespace: biological_process
def: "The cell cycle process whereby centromeres are physically detached from each other during chromosome separation." [GOC:mah]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051304 ! chromosome separation

[Term]
id: GO:0034511
name: U3 snoRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with U3 small nucleolar RNA." [GOC:mah]
is_a: GO:0030515 ! snoRNA binding

[Term]
id: GO:0034512
name: box C/D snoRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with box C/D small nucleolar RNA." [GOC:mah]
is_a: GO:0030515 ! snoRNA binding

[Term]
id: GO:0034513
name: box H/ACA snoRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with box H/ACA small nucleolar RNA." [GOC:mah]
is_a: GO:0030515 ! snoRNA binding

[Term]
id: GO:0034514
name: mitochondrial unfolded protein response
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondrial matrix; results in transcriptional upregulation of nuclear genes encoding mitochondrial stress proteins." [GOC:mah, PMID:17849004]
synonym: "mtUPR" EXACT []
is_a: GO:0034620 ! cellular response to unfolded protein

[Term]
id: GO:0034515
name: proteasome storage granule
namespace: cellular_component
def: "A multisubunit proteasome complex that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state." [GOC:rb, PMID:18504300]
synonym: "PSG" EXACT []
is_a: GO:0031597 ! cytosolic proteasome complex

[Term]
id: GO:0034516
name: response to vitamin B6
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah, GOC:rph]
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0034517
name: ribophagy
namespace: biological_process
def: "The process by which cells degrade mature ribosomes under conditions of starvation." [PMID:18391941]
is_a: GO:0006914 ! autophagy

[Term]
id: GO:0034518
name: RNA cap binding complex
namespace: cellular_component
def: "Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA." [GOC:mah]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0034519
name: cytoplasmic RNA cap binding complex
namespace: cellular_component
def: "A protein complex found in the cytoplasm that binds the 5' cap structure of an mRNA, and typically consists of the cap-binding protein eIF4E, the adaptor protein eIF4G, and a multi-factor complex comprising eIF1, eIF2, eIF3 and eIF5. This complex mediates recruitment of the 40S subunit to mRNA." [PMID:16405910]
is_a: GO:0034518 ! RNA cap binding complex

[Term]
id: GO:0034520
name: 2-naphthaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+." [UM-BBD_reactionID:r0772]
xref: EC:1.2.1.-
xref: UM-BBD_enzymeID:e0483
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034521
name: 1-naphthoic acid dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-naphthoic acid + NADH + O2 + H+ = cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene + NAD+." [UM-BBD_reactionID:r0773]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0484
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0034522
name: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene = 1,2-dihydroxy-8-carboxynaphthalene + 2H+ + 2e-." [UM-BBD_reactionID:r0774]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0485
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034523
name: 3-formylsalicylate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-formylsalicylic acid +O2 + H2O = 2-hydroxyisophthalic acid +H2O2." [UM-BBD_reactionID:r0777]
xref: EC:1.2.3.-
xref: UM-BBD_enzymeID:e0486
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0034524
name: 2-hydroxyisophthalate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyisophthalic acid = salicylate + CO2." [UM-BBD_reactionID:r0776]
xref: EC:4.1.1.-
xref: UM-BBD_enzymeID:e0487
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034525
name: 1-naphthaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH + H+." [UM-BBD_reactionID:r0787]
xref: EC:1.2.1.-
xref: UM-BBD_enzymeID:e0489
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034526
name: 2-methylnaphthalene hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylnaphthalene + NADH + O2 + H+ = 2-hydroxymethylnaphthalene + NAH+ + H2O." [UM-BBD_reactionID:r0788]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0490
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034527
name: 1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxy-8-carboxynaphthalene +O2 = 2-carboxy-2-hydroxy-8-carboxychromene." [UM-BBD_reactionID:r0790]
xref: EC:1.13.-.-
xref: UM-BBD_enzymeID:e0491
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0034528
name: 2-carboxy-2-hydroxy-8-carboxychromene isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate." [UM-BBD_reactionID:r0791]
xref: EC:5.3.99.-
xref: UM-BBD_enzymeID:e0492
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0034529
name: 2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-3-carboxybenzalpyruvate + H2O = 3-formylsalicylic acid + pyruvate." [UM-BBD_reactionID:r0792]
xref: EC:4.1.2.-
xref: UM-BBD_enzymeID:e0493
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0034530
name: 4-hydroxymethylsalicyaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxymethylsalicylaldehyde + NAD+ + H2O = 4-hydroxymethylsalicylate + NADH + 2H+." [UM-BBD_reactionID:r0767]
xref: EC:1.2.1.-
xref: UM-BBD_enzymeID:e0495
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034531
name: 2-hydroxy-4-hydroxymethylbenzalpyruvate hydratase-aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-4-hydroxymethylbenzalpyruvate + H2O = pyruvate + 4-hydroxymethylsalicylaldehyde." [UM-BBD_reactionID:r0766]
xref: EC:4.1.2.-
xref: UM-BBD_enzymeID:e0496
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0034532
name: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate = 2-hydroxy-4-hydroxymethylbenzalpyruvate." [UM-BBD_reactionID:r0765]
xref: EC:5.3.99.-
xref: UM-BBD_enzymeID:e0497
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0034533
name: 1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxy-7-hydroxymethylnaphthalene + O2 = 2-hydroxy-7-hydroxymethylchromene-2-carboxylate." [UM-BBD_reactionID:r0764]
xref: EC:1.13.-.-
xref: UM-BBD_enzymeID:e0498
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0034534
name: 1-methylnaphthalene hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-methylnaphthalene + NADH + H+ + O2 = 1-hydroxymethylnaphthalene + NAD+ + H2O." [UM-BBD_reactionID:r0795]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0500
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034535
name: 1,2-dihydroxy-8-methylnaphthalene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxy-8-methylnaphthalene + O2 = 2-hydroxy-8-methylchromene-2-carboxylate + H+." [UM-BBD_reactionID:r0781]
xref: EC:1.13.-.-
xref: UM-BBD_enzymeID:e0501
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0034536
name: 2-hydroxy-8-methylchromene-2-carboxylate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-8-methylchromene-2-carboxylate = 2-hydroxy-3-methylbenzalpyruvate." [UM-BBD_reactionID:r0782]
xref: EC:5.3.99.-
xref: UM-BBD_enzymeID:e0502
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0034537
name: 2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-3-methylbenzalpyruvate + H2O = pyruvate + 3-methylsalicylaldehyde." [UM-BBD_reactionID:r0783]
xref: EC:4.1.2.-
xref: UM-BBD_enzymeID:e0503
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0034538
name: 3-methylsalicylaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylsalicylaldehyde + NAD+ = 3-methylsalicylate + NADH + H+." [UM-BBD_reactionID:r0784]
xref: EC:1.2.1.-
xref: UM-BBD_enzymeID:e0504
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034539
name: 3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,3',5,5'-Tetrabromobisphenol A + 2 H+ + 2 e- = 3,3',5-tribromobisphenol A + HBr." [UM-BBD_reactionID:r0821]
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0510
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034540
name: 3-monobromobisphenol A reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-monobromobisphenol A+ 2 H+ + 2 e- = bisphenol A + HBr." [UM-BBD_reactionID:r0824]
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0513
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034541
name: dimethylarsinite methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylarsenous acid + R2S-CH3 = trimethylarsine oxide + R2SH." [UM-BBD_reactionID:r0806]
xref: EC:2.1.1.-
xref: UM-BBD_enzymeID:e0516
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0034542
name: trimethylarsine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: trimethylarsine oxide + 2 H+ + 2 e- = trimethylarsine + H2O." [UM-BBD_reactionID:r0807]
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0517
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034543
name: 5-aminosalicylate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-aminosalicylate + O2 = cis-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate." [UM-BBD_reactionID:r0809]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0518
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034544
name: trans-ACOHDA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate + H2O = fumarylpyruvate + NH3." [UM-BBD_reactionID:r0810]
xref: EC:3.5.99.-
xref: UM-BBD_enzymeID:e0519
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0034545
name: fumarylpyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+." [UM-BBD_reactionID:r0811]
xref: EC:3.7.1.-
xref: UM-BBD_enzymeID:e0520
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034546
name: 2,4-dichloroaniline reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichloroaniline + 2 H+ + 2 e- = 4-chloroaniline + HCl." [UM-BBD_reactionID:r0819]
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0521
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034547
name: N-cyclopropylmelamine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyromazine + H2O = N-cyclopropylammeline + NH3." [UM-BBD_reactionID:r0825]
xref: EC:3.5.4.-
xref: MetaCyc:RXN-8018
xref: UM-BBD_enzymeID:e0524
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0034548
name: N-cyclopropylammeline deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-cyclopropylammeline + H2O = N-cyclopropylammelide + NH3." [UM-BBD_reactionID:r0826]
xref: EC:3.5.4.-
xref: MetaCyc:RXN-8019
xref: UM-BBD_enzymeID:e0525
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0034549
name: N-cyclopropylammelide alkylamino hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-cyclopropylammelide + H2O = cyclopropylamine + cyanuric acid." [UM-BBD_reactionID:r0827]
xref: EC:3.5.4.-
xref: MetaCyc:RXN-8020
xref: UM-BBD_enzymeID:e0526
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0034550
name: dimethylarsinate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylarsinate + 3 H+ + 2 e- = dimethylarsinous acid + H2O." [UM-BBD_reactionID:r0838]
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0529
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034551
name: mitochondrial respiratory chain complex III assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as cytochrome c oxidase), in the mitochondrial inner membrane." [GOC:df]
synonym: "mitochondrial cytochrome bc(1) complex assembly" EXACT [GOC:mcc]
is_a: GO:0017062 ! respiratory chain complex III assembly
is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly

[Term]
id: GO:0034552
name: respiratory chain complex II assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II." [GOC:df]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0034553
name: mitochondrial respiratory chain complex II assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane." [GOC:df]
is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly
is_a: GO:0034552 ! respiratory chain complex II assembly

[Term]
id: GO:0034554
name: 3,3',5-tribromobisphenol A reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,3',5-tribromobisphenol A + 2 H+ + 2 e- = 3,3'-dibromobisphenol A + HBr." [UM-BBD_reactionID:r0842]
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0532
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034555
name: 3,3'-dibromobisphenol A reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,3'-dibromobisphenol A + 2H+ + 2 e- = 3-monobromobisphenol A + HBr." [UM-BBD_reactionID:r0844]
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0533
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034556
name: nitrobenzoate nitroreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: o-nitrobenzoate + NADPH + H+ = o-hydroxylaminobenzoate + NADP+." [UM-BBD_reactionID:r0849]
xref: EC:1.7.1.-
xref: UM-BBD_enzymeID:e0536
is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor

[Term]
id: GO:0034557
name: 2-hydroxylaminobenzoate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxylaminobenzoate + NAD(P)H = anthranilate + NAD(P)+ + H2O." [MetaCyc:RXN-8848]
synonym: "o-hydroxylaminobenzoate nitroreductase activity" RELATED [UM-BBD_enzymeID:e0537]
xref: EC:1.4.-.-
xref: MetaCyc:RXN-8848
xref: UM-BBD_enzymeID:e0537
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0034558
name: technetium (VII) reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: pertechnetate ion + 3/2 H2 = technetium (IV) oxide + H2O + OH-." [UM-BBD_reactionID:r0859]
xref: EC:1.12.-.-
xref: UM-BBD_enzymeID:e0542
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0034559
name: bisphenol A hydroxylase B activity
namespace: molecular_function
def: "Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 1,2-bis(4-hydroxyphenyl)-2-propanol + NAD+ + H2O." [UM-BBD_reactionID:r0860]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0543
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034560
name: bisphenol A hydroxylase A activity
namespace: molecular_function
def: "Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + NAD+ + H2O." [UM-BBD_reactionID:r0861]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0544
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034561
name: 1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-bis(4-hydroxyphenyl)-2-propanol = 4,4'-dihydroxy-alpha-methylstilbene + H2O." [UM-BBD_reactionID:r0862]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0545
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034562
name: 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,2-bis(4-hydroxyphenyl)-1-propanol + NADH + H+ + O2 = 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + NAD+ + H2O." [UM-BBD_reactionID:r0864]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0547
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034563
name: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + O2 = 4-hydroxyphenacyl alcohol + 4-hydroxybenzoate + 2 H+ + 2e-." [UM-BBD_reactionID:r0867]
xref: EC:1.13.-.-
xref: UM-BBD_enzymeID:e0548
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034564
name: 4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,4'-dihydroxy-alpha-methylstilbene + O2 = 4-hydroxybenzaldehyde + 4-hydroxyacetophenone + 2 H+ + 2 e-." [UM-BBD_reactionID:r0866]
xref: EC:1.3.-.-
xref: UM-BBD_enzymeID:e0549
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034565
name: 1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-nitro-1,2-dihydro-1,3,5-triazine + 2 H2O = 1-nitro-1,3,5-triazinane-2,4-diol." [UM-BBD_reactionID:r0872]
xref: EC:3.5.99.-
xref: UM-BBD_enzymeID:e0552
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0034566
name: formamide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: formamide + H2O = formate + NH3 + H+." [UM-BBD_reactionID:r0873]
xref: EC:3.5.1.-
xref: MetaCyc:FORMAMIDASE-RXN
xref: UM-BBD_enzymeID:e0554
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0034567
name: chromate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: chromate = chromium (III)." [UM-BBD_reactionID:r0884]
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0556
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034568
name: isoproturon dimethylaminedehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: isoproturon + H2O = formaldehyde + monodemethylisoproturon + 2 H+ + 2 e-." [UM-BBD_reactionID:r0892]
xref: EC:1.5.99.-
xref: UM-BBD_enzymeID:e0561
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0034569
name: monodemethylisoproturon dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: monodemethylisoproturon + H2O = hydroxymonodemethylisoproturon + 2H+ + 2 e-." [UM-BBD_reactionID:r0893]
xref: EC:1.17.99.-
xref: UM-BBD_enzymeID:e0562
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0034570
name: hydroxymonomethylisoproturon dimethylaminedehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxymonodemethylisoproturon + H2O = formaldehyde + 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-." [UM-BBD_reactionID:r0894]
xref: EC:1.5.99.-
xref: UM-BBD_enzymeID:e0563
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0034571
name: 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4'-(2-hydroxyisopropyl)phenylurea + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + carbamic acid." [UM-BBD_reactionID:r0895]
xref: EC:3.5.1.-
xref: UM-BBD_enzymeID:e0564
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0034572
name: monodemethylisoproturon dimethylaminedehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: monodemethylisoproturon + H2O = didemethylisoproturon + formaldehyde + 2 H+ + 2 e-." [UM-BBD_reactionID:r0897]
xref: EC:1.5.99.-
xref: UM-BBD_enzymeID:e0565
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0034573
name: didemethylisoproturon amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: didemethylisoproturon + H2O = carbamic acid + 4-isopropylaniline." [UM-BBD_reactionID:r0898]
xref: EC:3.5.1.-
xref: UM-BBD_enzymeID:e0566
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0034574
name: didemethylisoproturon dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: didemethylisoproturon + H2O = 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-." [UM-BBD_reactionID:r0899]
xref: EC:1.17.99.-
xref: UM-BBD_enzymeID:e0567
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0034575
name: 4-isopropylaniline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-isopropylaniline + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + 2 H+ + 2 e-." [UM-BBD_reactionID:r0901]
xref: EC:1.17.99.-
xref: UM-BBD_enzymeID:e0569
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0034576
name: N-isopropylacetanilide amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-isopropylacetanilide + OH- = N-isopropylaniline + acetate." [UM-BBD_reactionID:r0913]
xref: EC:3.5.1.-
xref: UM-BBD_enzymeID:e0570
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0034577
name: N-isopropylacetaniline monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-isopropylacetanilide + 1/2 O2 = acetanilide + acetone." [UM-BBD_reactionID:r0914]
xref: EC:1.14.15.-
xref: UM-BBD_enzymeID:e0571
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034578
name: limonene 8-hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: limonene + H2O = alpha-terpineol." [UM-BBD_reactionID:r0916]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0572
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034579
name: (1-methylpentyl)succinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: fumarate + n-hexane = (1-methylpentyl)succinate." [UM-BBD_reactionID:r0920]
xref: EC:4.1.99.-
xref: UM-BBD_enzymeID:e0573
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0034580
name: 4-methyloctanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methyloctanoyl-CoA = 4-methyloct-2-enoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0924]
xref: EC:1.3.99.-
xref: UM-BBD_enzymeID:e0577
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034581
name: 4-methyloct-2-enoyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methyloct-2-enoyl-CoA + H2O = 3-hydroxy-4-methyloctanoyl-CoA." [UM-BBD_reactionID:r0925]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0578
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034582
name: 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-4-methyloctanoyl-CoA = 4-methyl-3-oxooctanoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0926]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0579
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034583
name: 21U-RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 21U-RNA, a 21-nucleotide RNA characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0034584
name: piRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv]
synonym: "Piwi-associated RNA binding" EXACT []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0034585
name: 21U-RNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv]
synonym: "21U-RNA metabolism" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0034586
name: 21U-RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv]
synonym: "21U-RNA breakdown" EXACT []
synonym: "21U-RNA catabolism" EXACT []
synonym: "21U-RNA degradation" EXACT []
is_a: GO:0034585 ! 21U-RNA metabolic process
is_a: GO:0034661 ! ncRNA catabolic process

[Term]
id: GO:0034587
name: piRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv]
synonym: "piRNA metabolism" EXACT []
synonym: "Piwi-associated RNA metabolic process" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0034588
name: piRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv]
synonym: "piRNA breakdown" EXACT []
synonym: "piRNA catabolism" EXACT []
synonym: "piRNA degradation" EXACT []
synonym: "Piwi-associated RNA catabolic process" EXACT []
is_a: GO:0034587 ! piRNA metabolic process
is_a: GO:0034661 ! ncRNA catabolic process

[Term]
id: GO:0034589
name: hydroxyproline transport
namespace: biological_process
def: "The directed movement of hydroxyproline into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah, PMID:14502423]
synonym: "4-hydroxyproline transport" EXACT []
synonym: "L-hydroxyproline transport" NARROW []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0034590
name: L-hydroxyproline transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of L-hydroxyproline from one side of a membrane to the other." [GOC:mah, PMID:14502423]
synonym: "4-hydroxyproline transmembrane transporter activity" BROAD []
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity

[Term]
id: GO:0034591
name: rhoptry lumen
namespace: cellular_component
def: "The volume enclosed by the rhoptry membrane." [GOC:rph, PMID:17997128]
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044464 ! cell part
relationship: part_of GO:0020008 ! rhoptry

[Term]
id: GO:0034592
name: synaptic vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the synaptic vesicle membrane." [GOC:rph]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0008021 ! synaptic vesicle

[Term]
id: GO:0034593
name: phosphatidylinositol bisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the removal of one of the two phosphate groups of a phosphatidylinositol bisphosphate." [GOC:mah]
synonym: "diphosphoinositide phosphatase activity" RELATED []
synonym: "phosphatidyl-inositol-bisphosphate phosphatase activity" EXACT []
synonym: "phosphatidylinositol-bisphosphatase activity" RELATED []
synonym: "triphosphoinositide phosphatase activity" RELATED []
synonym: "triphosphoinositide phosphomonoesterase activity" RELATED []
is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity

[Term]
id: GO:0034594
name: phosphatidylinositol trisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the removal of one of the three phosphate groups of a phosphatidylinositol trisphosphate." [GOC:mah]
is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity

[Term]
id: GO:0034595
name: phosphoinositide 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the removal the of the 5-phosphate group of a phosphatidylinositol phosphate." [GOC:elh]
subset: gosubset_prok
synonym: "polyphosphoinositol lipid 5-phosphatase activity" EXACT []
is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity

[Term]
id: GO:0034596
name: phosphoinositide 4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the removal the of the 4-phosphate group of a phosphatidylinositol phosphate." [GOC:mah]
is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity

[Term]
id: GO:0034597
name: phosphatidyl-inositol-4,5-bisphosphate 4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [GOC:mah]
synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT []
synonym: "D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT []
synonym: "inositol polyphosphate 4-phosphatase type II activity" RELATED [EC:3.1.3.66]
synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT []
xref: EC:3.1.3.66
xref: MetaCyc:3.1.3.66-RXN
is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity
is_a: GO:0034596 ! phosphoinositide 4-phosphatase activity
is_a: GO:0042577 ! lipid phosphatase activity

[Term]
id: GO:0034598
name: phosphothreonine lyase activity
namespace: molecular_function
def: "Catalysis of the removal of the phosphate group from phosphothreonine by cleavage of the C-OP bond with the concomitant abstraction of the alpha proton, generating a double bond-containing product." [PMID:17303758, PMID:18084305]
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034599
name: cellular response to oxidative stress
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah]
synonym: "adaptive response to oxidative stress" NARROW [GOC:add, GOC:vk]
is_a: GO:0006979 ! response to oxidative stress
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0034601
name: oxoglutarate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NAD(P)+ = succinyl-CoA + CO2 + NAD(P)H." [GOC:mah]
xref: EC:1.2.1.52
xref: MetaCyc:OXOGLUTARATE-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034602
name: oxoglutarate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH." [GOC:mah]
xref: EC:1.2.1.52
xref: MetaCyc:OXOGLUTARATE-DEHYDROGENASE-NADP+-RXN
is_a: GO:0034601 ! oxoglutarate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0034603
name: pyruvate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H." [GOC:mah]
xref: EC:1.2.1.51
xref: MetaCyc:PYRUVATE-DEHYDROGENASE-NADP+-RXN
is_a: GO:0004738 ! pyruvate dehydrogenase activity
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034604
name: pyruvate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH." [GOC:mah]
xref: EC:1.2.1.51
xref: MetaCyc:PYRUVATE-DEHYDROGENASE-NADP+-RXN
is_a: GO:0034603 ! pyruvate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0034605
name: cellular response to heat
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah]
synonym: "cellular response to heat stress" EXACT []
is_a: GO:0009408 ! response to heat
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0034606
name: response to hermaphrodite contact
namespace: biological_process
def: "The response by the male to a hermaphrodite after initial contact following mate finding. The male stops forward locomotion, presses the ventral side of his tail against his partner's body, and begins moving backward along the hermaphrodite. Male response behavior is initiated when sensory neurons located in the rays of his tail contact a potential mate." [PMID:18050467, WB_REF:WBPaper00002109]
is_a: GO:0060179 ! male mating behavior

[Term]
id: GO:0034607
name: turning behavior involved in mating
namespace: biological_process
def: "The sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [PMID:18050467, WB_REF:WBPaper00002109]
synonym: "turning behavior during mating" EXACT []
is_a: GO:0035178 ! turning behavior
is_a: GO:0060179 ! male mating behavior

[Term]
id: GO:0034608
name: vulval location
namespace: biological_process
def: "Location, by the male, of his partner's vulva when backing along the ventral side of the hermaphrodite during mating. The male stops at the vulva, coordinates his movements to the hermaphrodite's, and positions his tail precisely over the vulva so that he may insert his spicules and ejaculate." [PMID:18050467]
is_a: GO:0060179 ! male mating behavior

[Term]
id: GO:0034609
name: spicule insertion
namespace: biological_process
def: "Insertion of the male copulatory spicules into the hermaphrodite. Spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva." [PMID:18050467]
is_a: GO:0060179 ! male mating behavior

[Term]
id: GO:0034610
name: oligodeoxyribonucleotidase activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage of oligodeoxyribonucleotides to yield deoxyribonucleoside 5'-phosphates." [GOC:mah]
synonym: "DNA oligonucleotidase activity" EXACT []
is_a: GO:0004536 ! deoxyribonuclease activity
is_a: GO:0008946 ! oligonucleotidase activity

[Term]
id: GO:0034611
name: oligoribonucleotidase activity
namespace: molecular_function
def: "Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates." [GOC:mah]
synonym: "RNA oligonucleotidase activity" EXACT []
is_a: GO:0004540 ! ribonuclease activity
is_a: GO:0008946 ! oligonucleotidase activity

[Term]
id: GO:0034612
name: response to tumor necrosis factor
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]
synonym: "response to TNF" EXACT []
is_a: GO:0034097 ! response to cytokine stimulus

[Term]
id: GO:0034613
name: cellular protein localization
namespace: biological_process
alt_id: GO:0016249
def: "Any process by which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]
synonym: "channel localizer activity" NARROW [GOC:mah]
is_a: GO:0008104 ! protein localization
is_a: GO:0070727 ! cellular macromolecule localization

[Term]
id: GO:0034614
name: cellular response to reactive oxygen species
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to active oxygen species" EXACT []
synonym: "cellular response to AOS" EXACT []
synonym: "cellular response to reactive oxidative species" EXACT []
synonym: "cellular response to reactive oxygen intermediate" EXACT []
synonym: "cellular response to ROI" EXACT []
synonym: "cellular response to ROS" EXACT []
is_a: GO:0000302 ! response to reactive oxygen species
is_a: GO:0034599 ! cellular response to oxidative stress

[Term]
id: GO:0034615
name: GCH1 complex
namespace: cellular_component
def: "A protein complex that possesses GTP cyclohydrolase I activity. In E. coli and human, the complex is a homodecamer, and monomers are catalytically inactive." [PMID:16696853]
synonym: "GTP cyclohydrolase I complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0034616
name: response to laminar fluid shear stress
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls." [GOC:ecd]
is_a: GO:0034405 ! response to fluid shear stress

[Term]
id: GO:0034617
name: tetrahydrobiopterin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions." [ChEBI:15372, GOC:BHF, GOC:mah, GOC:rl]
synonym: "BH4 binding" EXACT []
synonym: "H4biopterin binding" EXACT []
synonym: "sapropterin binding" EXACT []
is_a: GO:0050662 ! coenzyme binding

[Term]
id: GO:0034618
name: arginine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 2-amino-5-(carbamimidamido)pentanoic acid." [ChEBI:29016, GOC:BHF, GOC:rl]
synonym: "aminopentanoic acid binding" RELATED []
synonym: "Arg binding" EXACT []
is_a: GO:0016597 ! amino acid binding

[Term]
id: GO:0034619
name: cellular chaperone-mediated protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell, mediated by chaperone molecules that do not form part of the finished complex." [GOC:mah]
subset: gosubset_prok
synonym: "chaperone activity" RELATED []
is_a: GO:0051131 ! chaperone-mediated protein complex assembly

[Term]
id: GO:0034620
name: cellular response to unfolded protein
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah]
comment: Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to one specific response to the presence of unfolded proteins in the ER.
subset: gosubset_prok
synonym: "heat shock protein activity" RELATED []
is_a: GO:0006986 ! response to unfolded protein
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0071216 ! cellular response to biotic stimulus
is_a: GO:0071445 ! cellular response to protein stimulus

[Term]
id: GO:0034621
name: cellular macromolecular complex subunit organization
namespace: biological_process
def: "Any process carried out at the cellular level by which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a macromolecular complex." [GOC:mah, GOC:mtg_mpo]
subset: gosubset_prok
synonym: "cellular macromolecular complex organization" EXACT []
synonym: "cellular macromolecular complex subunit organisation" EXACT [GOC:curators]
is_a: GO:0009987 ! cellular process
is_a: GO:0043933 ! macromolecular complex subunit organization

[Term]
id: GO:0034622
name: cellular macromolecular complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "cellular macromolecule complex assembly" EXACT []
is_a: GO:0034621 ! cellular macromolecular complex subunit organization
is_a: GO:0065003 ! macromolecular complex assembly

[Term]
id: GO:0034623
name: cellular macromolecular complex disassembly
namespace: biological_process
def: "The disaggregation of a macromolecular complex into its constituent components, carried out at the cellular level." [GOC:mah]
subset: gosubset_prok
synonym: "cellular macromolecule complex disassembly" EXACT []
is_a: GO:0032984 ! macromolecular complex disassembly
is_a: GO:0034621 ! cellular macromolecular complex subunit organization

[Term]
id: GO:0034624
name: DNA recombinase assembly involved in gene conversion at mating-type locus
namespace: biological_process
def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA, involved in the conversion of the mating-type locus from one allele to another." [GOC:mah]
is_a: GO:0000730 ! DNA recombinase assembly
relationship: part_of GO:0007534 ! gene conversion at mating-type locus

[Term]
id: GO:0034625
name: fatty acid elongation, monounsaturated fatty acid
namespace: biological_process
def: "Elongation of a fatty acid chain into which one C-C double bond has been introduced." [GOC:mah]
subset: gosubset_prok
is_a: GO:0019368 ! fatty acid elongation, unsaturated fatty acid

[Term]
id: GO:0034626
name: fatty acid elongation, polyunsaturated fatty acid
namespace: biological_process
def: "Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced." [GOC:mah]
subset: gosubset_prok
is_a: GO:0019368 ! fatty acid elongation, unsaturated fatty acid

[Term]
id: GO:0034627
name: de novo NAD biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan or aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:imk, PMID:17161604]
is_a: GO:0009435 ! NAD biosynthetic process

[Term]
id: GO:0034628
name: de novo NAD biosynthetic process from aspartate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:imk]
is_a: GO:0019355 ! nicotinamide nucleotide biosynthetic process from aspartate
is_a: GO:0034627 ! de novo NAD biosynthetic process

[Term]
id: GO:0034629
name: cellular protein complex localization
namespace: biological_process
def: "Any process by which a protein complex is transported to, or maintained in, a specific location within a cell." [GOC:mah]
synonym: "establishment and maintenance of cellular protein complex localization" EXACT []
is_a: GO:0031503 ! protein complex localization
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0034630
name: RITS complex localization
namespace: biological_process
def: "Any process by which a RITS complex is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "establishment and maintenance of RITS complex localization" EXACT []
is_a: GO:0034629 ! cellular protein complex localization

[Term]
id: GO:0034631
name: microtubule anchoring at spindle pole body
namespace: biological_process
def: "Any process by which a microtubule is maintained in a specific location in a cell by attachment to a spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [GOC:mah, PMID:17486116]
synonym: "attachment of spindle microtubules to SPB" EXACT []
synonym: "attachment of spindle microtubules to spindle pole body" EXACT []
synonym: "microtubule anchoring at SPB" EXACT []
is_a: GO:0034453 ! microtubule anchoring
relationship: part_of GO:0007051 ! spindle organization

[Term]
id: GO:0034632
name: retinol transporter activity
namespace: molecular_function
def: "Enables the directed movement of retinol into, out of, within or between cells. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah, GOC:vk]
synonym: "vitamin A1 transporter activity" EXACT []
is_a: GO:0051183 ! vitamin transporter activity

[Term]
id: GO:0034633
name: retinol transport
namespace: biological_process
def: "The directed movement of retinol into, out of, within or between cells by means of some external agent such as a transporter or pore. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah, GOC:vk]
synonym: "vitamin A1 transport" EXACT []
is_a: GO:0046865 ! terpenoid transport
is_a: GO:0051180 ! vitamin transport

[Term]
id: GO:0034634
name: glutathione transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of glutathione, the tripeptide glutamylcysteinylglycine, across a membrane into, out of, within or between cells." [GOC:mah]
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0034635
name: glutathione transport
namespace: biological_process
def: "The directed movement of glutathione, the tripeptide glutamylcysteinylglycine, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0042939 ! tripeptide transport

[Term]
id: GO:0034636
name: strand invasion involved in gene conversion at mating-type locus
namespace: biological_process
def: "The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA at the mating-type locus. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This process occurs as part of gene conversion at the mating-type locus." [GOC:mah]
is_a: GO:0042148 ! strand invasion
relationship: part_of GO:0007534 ! gene conversion at mating-type locus

[Term]
id: GO:0034637
name: cellular carbohydrate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells." [GOC:mah]
is_a: GO:0016051 ! carbohydrate biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0034638
name: phosphatidylcholine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:jp]
subset: gosubset_prok
synonym: "phosphatidylcholine breakdown" EXACT []
synonym: "phosphatidylcholine catabolism" EXACT []
synonym: "phosphatidylcholine degradation" EXACT []
is_a: GO:0046470 ! phosphatidylcholine metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process

[Term]
id: GO:0034639
name: L-amino acid efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of an L-amino acid from the inside of the cell to the outside of the cell across a membrane." [GOC:mah]
synonym: "L-amino acid efflux permease activity" EXACT []
synonym: "L-amino acid export transporter activity" EXACT []
is_a: GO:0015179 ! L-amino acid transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0034640
name: mitochondrion localization by microtubule attachment
namespace: biological_process
def: "The directed movement of a mitochondrion by attachment to a microtubule, followed by elongation of the microtubule by tubulin polymerization." [GOC:mah, PMID:12972644]
synonym: "mitochondrial localization by microtubule attachment" EXACT []
synonym: "mitochondrial migration by microtubule attachment" EXACT []
synonym: "mitochondrion migration by microtubule attachment" EXACT []
is_a: GO:0034643 ! mitochondrion localization, microtubule-mediated

[Term]
id: GO:0034641
name: cellular nitrogen compound metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah]
subset: goslim_pombe
subset: gosubset_prok
synonym: "cellular nitrogen compound metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0034642
name: mitochondrial migration along actin filament
namespace: biological_process
def: "The directed movement of a mitochondrion along a microfilament, mediated by motor proteins." [GOC:mah, PMID:15979253, PMID:16306220]
synonym: "mitochondrial migration along microfilament" EXACT []
synonym: "mitochondrial migration, actin-mediated" EXACT []
synonym: "mitochondrion migration along microfilament" EXACT []
synonym: "mitochondrion transport along actin filament" EXACT []
is_a: GO:0030048 ! actin filament-based movement
is_a: GO:0051654 ! establishment of mitochondrion localization

[Term]
id: GO:0034643
name: mitochondrion localization, microtubule-mediated
namespace: biological_process
def: "The directed movement of the mitochondrion to a specific location, by a process involving microtubules." [GOC:mah, PMID:12972644, PMID:15979253, PMID:16306220]
synonym: "microtubule-mediated mitochondrion localization" EXACT []
synonym: "mitochondrial localization, microtubule-mediated" EXACT []
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0051654 ! establishment of mitochondrion localization

[Term]
id: GO:0034644
name: cellular response to UV
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to ultraviolet light stimulus" EXACT []
synonym: "cellular response to ultraviolet radiation stimulus" EXACT []
synonym: "cellular response to UV light stimulus" EXACT []
synonym: "cellular response to UV radiation stimulus" EXACT []
is_a: GO:0009411 ! response to UV
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0034645
name: cellular macromolecule biosynthetic process
namespace: biological_process
alt_id: GO:0034961
def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells." [ChEBI:33694, GOC:mah]
synonym: "cellular biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "cellular macromolecule anabolism" EXACT [GOC:mah]
synonym: "cellular macromolecule biosynthesis" EXACT [GOC:mah]
synonym: "cellular macromolecule formation" EXACT [GOC:mah]
synonym: "cellular macromolecule synthesis" EXACT [GOC:mah]
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0034646
name: organelle-enclosing lipid monolayer
namespace: cellular_component
def: "A lipid monolayer that surrounds and encloses an organelle." [GOC:mah]
is_a: GO:0044446 ! intracellular organelle part

[Term]
id: GO:0034647
name: histone demethylase activity (H3-trimethyl-K4 specific)
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from trimethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:17550896]
synonym: "histone demethylase activity (H3-K4-me3 specific)" EXACT []
is_a: GO:0032453 ! histone demethylase activity (H3-K4 specific)

[Term]
id: GO:0034648
name: histone demethylase activity (H3-dimethyl-K4 specific)
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:17550896]
synonym: "histone demethylase activity (H3-K4-me2 specific)" EXACT []
is_a: GO:0032453 ! histone demethylase activity (H3-K4 specific)

[Term]
id: GO:0034649
name: histone demethylase activity (H3-monomethyl-K4 specific)
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from monomethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:17550896]
synonym: "histone demethylase activity (H3-K4-me1 specific)" EXACT []
is_a: GO:0032453 ! histone demethylase activity (H3-K4 specific)

[Term]
id: GO:0034650
name: cortisol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties." [ChEBI:17650, GOC:BHF, GOC:mah, GOC:rl]
synonym: "cortisol metabolism" EXACT []
is_a: GO:0008207 ! C21-steroid hormone metabolic process
is_a: GO:0008211 ! glucocorticoid metabolic process

[Term]
id: GO:0034651
name: cortisol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties." [ChEBI:17650, GOC:BHF, GOC:mah, GOC:rl]
synonym: "cortisol anabolism" NARROW []
synonym: "cortisol biosynthesis" EXACT []
synonym: "cortisol formation" EXACT []
synonym: "cortisol synthesis" EXACT []
is_a: GO:0006700 ! C21-steroid hormone biosynthetic process
is_a: GO:0006704 ! glucocorticoid biosynthetic process
is_a: GO:0034650 ! cortisol metabolic process

[Term]
id: GO:0034652
name: extrachromosomal circular DNA localization during cell aging
namespace: biological_process
def: "Any process by which extrachromosomal circular DNA molecules are transported to, or maintained in, a specific location in cells as they age." [GOC:jp, PMID:18660802]
comment: Note that the term string was changed to be consistent with placement of this term in cell aging hierarchy.
synonym: "extrachromosomal circular DNA localization during cell ageing" EXACT []
is_a: GO:0001301 ! progressive alteration of chromatin during cell aging

[Term]
id: GO:0034653
name: retinoic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of retinoic acid, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah]
synonym: "retinoic acid breakdown" EXACT []
synonym: "retinoic acid catabolism" EXACT []
synonym: "retinoic acid degradation" EXACT []
synonym: "vitamin A1 acid catabolic process" EXACT []
is_a: GO:0042363 ! fat-soluble vitamin catabolic process
is_a: GO:0042573 ! retinoic acid metabolic process

[Term]
id: GO:0034654
name: nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]
subset: gosubset_prok
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid anabolism" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid formation" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid synthesis" EXACT []
is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process

[Term]
id: GO:0034655
name: nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah]
subset: gosubset_prok
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT []
synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT []
is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process

[Term]
id: GO:0034656
name: nucleobase, nucleoside and nucleotide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides and nucleotides." [GOC:mah]
synonym: "nucleobase, nucleoside and nucleotide breakdown" EXACT []
synonym: "nucleobase, nucleoside and nucleotide catabolism" EXACT []
synonym: "nucleobase, nucleoside and nucleotide degradation" EXACT []
is_a: GO:0034655 ! nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process

[Term]
id: GO:0034657
name: GID complex
namespace: cellular_component
def: "A protein complex with ubiquitin ligase activity that is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. In S. cerevisiae, the GID (Glucose Induced degradation Deficient) complex consists of Vid30p, Rmd5p, Vid24p, Vid28p, Gid7p, Gid8p, and Fyv10p." [PMID:12686616, PMID:18508925]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0034658
name: isopropylmalate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of isopropylmalate from one side of the membrane to the other." [GOC:mah]
is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity

[Term]
id: GO:0034659
name: isopropylmalate transport
namespace: biological_process
def: "The directed movement of isopropylmalate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
is_a: GO:0006835 ! dicarboxylic acid transport

[Term]
id: GO:0034660
name: ncRNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs)." [GOC:mah]
subset: gosubset_prok
synonym: "ncRNA metabolism" EXACT []
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0034661
name: ncRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs)." [GOC:rb, PMID:18591258]
synonym: "ncRNA breakdown" EXACT []
synonym: "ncRNA catabolism" EXACT []
synonym: "ncRNA degradation" EXACT []
is_a: GO:0006401 ! RNA catabolic process
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0034662
name: CFTR-NHERF-ezrin complex
namespace: cellular_component
def: "A protein complex that contains ezrin, Na+/H+ exchanger regulatory factor (NHERF, also called EBP50), and two copies of the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR molecules interact with NHERF via their cytoplasmic tail domains; the complex is thought to link the CFTR channel to the actin cytoskeleton and contribute to the regulation of channel activity." [PMID:16129695, PMID:16798722, PMID:16926444]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0034663
name: endoplasmic reticulum chaperone complex
namespace: cellular_component
def: "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965]
synonym: "endoplasmic reticulum network complex" RELATED []
synonym: "ER chaperone complex" EXACT []
synonym: "ER network complex" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0034664
name: Ig heavy chain-bound endoplasmic reticulum chaperone complex
namespace: cellular_component
def: "A protein complex that is located in the endoplasmic reticulum (ER) and is formed by the association of an immunoglobulin heavy chain with the proteins of the ER chaperone complex; the latter include BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965]
synonym: "Ig heavy chain-bound ER chaperone complex" EXACT []
synonym: "immunoglobulin heavy chain-bound endoplasmic reticulum chaperone complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0034665
name: alpha1-beta1 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha1 subunit and one beta1 subunit." [PMID:12297042]
synonym: "ITGA1-ITGB1 complex" NARROW []
synonym: "VLA-1 complex" EXACT []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034666
name: alpha2-beta1 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha2 subunit and one beta1 subunit." [PMID:12297042]
synonym: "ITGA2-ITGB1 complex" NARROW [CORUM:2432]
synonym: "VLA-2 complex" EXACT [PMID:3546305]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034667
name: alpha3-beta1 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha3 subunit and one beta1 subunit." [PMID:12297042]
synonym: "ITGA3-ITGB1 complex" NARROW [CORUM:2406]
synonym: "VLA-3 complex" EXACT [PMID:3546305]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034668
name: alpha4-beta1 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha4 subunit and one beta1 subunit." [PMID:12297042]
synonym: "ITGA4-ITGB1 complex" NARROW []
synonym: "VLA-4 complex" EXACT []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034669
name: alpha4-beta7 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha4 subunit and one beta7 subunit." [PMID:12297042]
synonym: "ITGA4-ITGB7 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034670
name: chemotaxis to arachidonic acid
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to the presence of arachidonic acid." [GOC:go_curators, PMID:18202452]
is_a: GO:0006935 ! chemotaxis

[Term]
id: GO:0034671
name: retinoic acid receptor signaling pathway involved in pronephros anterior/posterior pattern specification
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the pronephros." [GOC:mh]
synonym: "retinoic acid receptor signalling pathway involved in pronephros anterior-posterior patterning" EXACT [GOC:mah]
is_a: GO:0048384 ! retinoic acid receptor signaling pathway
relationship: part_of GO:0034672 ! pronephros anterior/posterior pattern specification

[Term]
id: GO:0034672
name: pronephros anterior/posterior pattern specification
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the pronephros along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mah]
is_a: GO:0009952 ! anterior/posterior pattern formation
is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0034673
name: inhibin-betaglycan-ActRII complex
namespace: cellular_component
def: "A protein complex that consists of inhibin, type III transforming growth factor beta receptor (also known as betaglycan), and the type II activin receptor ActRII. The complex is thought to negatively regulate the activity of activin B." [GOC:BHF, PMID:10746731]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0034674
name: alpha5-beta1 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha5 subunit and one beta1 subunit." [PMID:12297042]
synonym: "ITGA5-ITGB1 complex" NARROW []
synonym: "VLA-5 complex" EXACT []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034675
name: alpha6-beta1 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha6 subunit and one beta1 subunit." [PMID:12297042]
synonym: "ITGA6-ITGB1 complex" NARROW [CORUM:2413]
synonym: "VLA-6 complex" EXACT [PMID:2649503]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034676
name: alpha6-beta4 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha6 subunit and one beta1 subunit." [PMID:12297042]
synonym: "ITGA6-ITGB4 complex" NARROW [CORUM:2323]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034677
name: alpha7-beta1 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha7 subunit and one beta1 subunit." [PMID:12297042]
synonym: "ITGA7-ITGB1 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034678
name: alpha8-beta1 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha8 subunit and one beta1 subunit." [PMID:12297042]
synonym: "ITGA8-ITGB1 complex" NARROW [CORUM:2439]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034679
name: alpha9-beta1 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha9 subunit and one beta1 subunit." [PMID:12297042]
synonym: "ITGA9-ITGB1 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034680
name: alpha10-beta1 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha10 subunit and one beta1 subunit." [PMID:12297042]
synonym: "ITGA10-ITGB1 complex" NARROW [CORUM:3057]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034681
name: alpha11-beta1 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alpha11 subunit and one beta1 subunit." [PMID:12297042]
synonym: "ITGA11-ITGB1 complex" NARROW [CORUM:3058]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034682
name: alphav-beta1 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alphav subunit and one beta1 subunit." [PMID:12297042]
synonym: "ITGAV-ITGB1 complex" NARROW [CORUM:2436]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034683
name: alphav-beta3 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alphav subunit and one beta3 subunit." [PMID:12297042]
synonym: "ITGAV-ITGB3 complex" NARROW [CORUM:2816]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034684
name: alphav-beta5 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alphav subunit and one beta5 subunit." [PMID:12297042]
synonym: "ITGAV-ITGB5 complex" NARROW [CORUM:2350]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034685
name: alphav-beta6 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alphav subunit and one beta6 subunit." [PMID:12297042]
synonym: "ITGAV-ITGB6 complex" NARROW [CORUM:2354]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034686
name: alphav-beta8 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alphav subunit and one beta8 subunit." [PMID:12297042]
synonym: "ITGAV-ITGB8 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034687
name: alphaL-beta2 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaL subunit and one beta2 subunit." [PMID:12297042]
synonym: "Itgal-Itgb2 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034688
name: alphaM-beta2 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaM subunit and one beta2 subunit." [PMID:12297042]
synonym: "Itgam-Itgb2 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034689
name: alphaX-beta2 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaX subunit and one beta2 subunit." [PMID:12297042]
synonym: "Itgax-Itgb2 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034690
name: alphaD-beta2 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaD subunit and one beta2 subunit." [PMID:12297042]
synonym: "Itgad-Itgb2 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034691
name: alphaE-beta7 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaE subunit and one beta7 subunit." [PMID:12297042]
synonym: "Itgae-Itgb7 complex" NARROW []
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0034692
name: E.F.G complex
namespace: cellular_component
def: "A protein complex that comprises three core spliceosomal proteins, designated E, F, and G. Formation of the E.F.G complex is essential but not sufficient for the formation of a stable U1 snRNP complex." [PMID:8641291]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0034693
name: U11/U12 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex formed by the association of the U11 and U12 small nuclear ribonucleoproteins." [GOC:mah, PMID:15146077]
synonym: "18S U11/U12 snRNP" NARROW []
synonym: "snRNP U11/U12" EXACT [GOC:mah]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0034694
name: response to prostaglandin stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus." [GOC:BHF, GOC:vk]
is_a: GO:0009725 ! response to hormone stimulus
is_a: GO:0033993 ! response to lipid

[Term]
id: GO:0034695
name: response to prostaglandin E stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus." [GOC:BHF, GOC:vk]
is_a: GO:0034694 ! response to prostaglandin stimulus

[Term]
id: GO:0034696
name: response to prostaglandin F stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus." [GOC:BHF, GOC:vk]
is_a: GO:0034694 ! response to prostaglandin stimulus

[Term]
id: GO:0034697
name: response to prostaglandin I stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus." [GOC:BHF, GOC:vk]
is_a: GO:0034694 ! response to prostaglandin stimulus

[Term]
id: GO:0034698
name: response to gonadotropin stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus." [GOC:BHF, GOC:vk]
is_a: GO:0009725 ! response to hormone stimulus

[Term]
id: GO:0034699
name: response to luteinizing hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus." [GOC:BHF, GOC:vk]
is_a: GO:0034698 ! response to gonadotropin stimulus

[Term]
id: GO:0034700
name: allulose 6-phosphate 3-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-allulose 6-phosphate = D-fructose 6-phosphate." [GOC:imk]
xref: MetaCyc:RXN0-304
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0034701
name: tripeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a tripeptide." [GOC:mah]
xref: EC:3.4.13
xref: MetaCyc:3.4.11.4-RXN
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0034702
name: ion channel complex
namespace: cellular_component
def: "A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient." [GOC:mah, ISBN:071673706X]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0016021 ! integral to membrane

[Term]
id: GO:0034703
name: cation channel complex
namespace: cellular_component
def: "An ion channel complex through which cations pass." [GOC:mah]
is_a: GO:0034702 ! ion channel complex

[Term]
id: GO:0034704
name: calcium channel complex
namespace: cellular_component
def: "An ion channel complex through which calcium ions pass." [GOC:mah]
is_a: GO:0034703 ! cation channel complex

[Term]
id: GO:0034705
name: potassium channel complex
namespace: cellular_component
def: "An ion channel complex through which potassium ions pass." [GOC:mah]
is_a: GO:0034703 ! cation channel complex

[Term]
id: GO:0034706
name: sodium channel complex
namespace: cellular_component
def: "An ion channel complex through which sodium ions pass." [GOC:mah]
is_a: GO:0034703 ! cation channel complex

[Term]
id: GO:0034707
name: chloride channel complex
namespace: cellular_component
def: "An ion channel complex through which chloride ions pass." [GOC:mah]
is_a: GO:0034702 ! ion channel complex

[Term]
id: GO:0034708
name: methyltransferase complex
namespace: cellular_component
def: "A protein complex that possesses methyltransferase activity." [GOC:mah]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0034709
name: methylosome
namespace: cellular_component
def: "A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains." [PMID:11713266, PMID:11756452]
synonym: "20S methylosome" EXACT []
synonym: "20S methyltransferase complex" EXACT []
is_a: GO:0034708 ! methyltransferase complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034710
name: inhibin complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an inhibin complex, a dimer of one inhibin-alpha subunit and one inhibin-beta subunit." [GOC:BHF, GOC:mah]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0034711
name: inhibin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers." [GOC:BHF, GOC:mah]
synonym: "inhibin monomer binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0034712
name: inhibin alpha binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with inhibin alpha." [GOC:BHF, GOC:mah]
is_a: GO:0034711 ! inhibin binding

[Term]
id: GO:0034713
name: type I transforming growth factor beta receptor binding
namespace: molecular_function
alt_id: GO:0005103
alt_id: GO:0005116
alt_id: GO:0005120
def: "Interacting selectively and non-covalently with a type I transforming growth factor beta receptor." [GOC:BHF, GOC:mah]
synonym: "babo binding" NARROW []
synonym: "babo ligand" NARROW []
synonym: "baboon binding" NARROW []
synonym: "baboon ligand" NARROW []
synonym: "baboon receptor ligand" NARROW []
synonym: "sax binding" NARROW []
synonym: "sax ligand" NARROW []
synonym: "saxophone binding" NARROW []
synonym: "saxophone ligand" NARROW []
synonym: "TGF-beta type I binding" EXACT []
synonym: "thickveins binding" NARROW []
synonym: "thickveins ligand" NARROW []
synonym: "tkv binding" NARROW []
synonym: "tkv ligand" NARROW []
synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED []
synonym: "transforming growth factor beta receptor type I binding" EXACT []
synonym: "type I TGF-beta binding" EXACT []
is_a: GO:0005160 ! transforming growth factor beta receptor binding

[Term]
id: GO:0034714
name: type III transforming growth factor beta receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type III transforming growth factor beta receptor." [GOC:BHF, GOC:mah]
synonym: "betaglycan binding" RELATED []
synonym: "TGF-beta type III binding" EXACT []
synonym: "transforming growth factor beta ligand binding to type III receptor" RELATED []
synonym: "transforming growth factor beta receptor type III binding" EXACT []
synonym: "type IIII TGF-beta binding" EXACT []
is_a: GO:0005160 ! transforming growth factor beta receptor binding

[Term]
id: GO:0034715
name: pICln-Sm protein complex
namespace: cellular_component
def: "A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG." [GOC:mah, PMID:11713266]
synonym: "6S pICln complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034716
name: Gemin3-Gemin4-Gemin5 complex
namespace: cellular_component
def: "A protein complex that contains Gemin3 (DDX20), Gemin4, and Gemin5, and can bind to snRNAs; may be an intermediate in SMN complex assembly." [GOC:mah, PMID:17640873]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0034717
name: Gemin6-Gemin7-unrip complex
namespace: cellular_component
def: "A protein complex that contains Gemin6, Gemin7, and unrip (STRAP), and can bind to snRNAs; may play a role in snRNP assembly." [GOC:mah, PMID:17640873]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0034718
name: SMN-Gemin2 complex
namespace: cellular_component
def: "A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex." [GOC:mah, PMID:17640873]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0034719
name: SMN-Sm protein complex
namespace: cellular_component
def: "A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [PMID:11522829, PMID:17401408]
comment: Note that this complex is sometimes referred to as the 'SMN complex', but it should not be confused with GO:0032797.
synonym: "SMN-containing protein complex" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034720
name: histone H3-K4 demethylation
namespace: biological_process
def: "The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone." [GOC:mah]
synonym: "H3K4 demethylation (me1 me2 and me3)" RELATED []
is_a: GO:0070076 ! histone lysine demethylation

[Term]
id: GO:0034721
name: histone H3-K4 demethylation, trimethyl-H3-K4-specific
namespace: biological_process
def: "The modification of histone H3 by the removal of a methyl group from a trimetylated lysine at position 4 of the histone." [GOC:mah]
synonym: "H3K4 demethylation (me3)" EXACT []
synonym: "histone H3-K4 tridemethylation" RELATED []
is_a: GO:0070076 ! histone lysine demethylation

[Term]
id: GO:0034722
name: gamma-glutamyl-peptidase activity
namespace: molecular_function
def: "Catalysis of the cleavage of a gamma-linked glutamate bond." [EC:3.4.19.9, MEROPS_fam:C26]
subset: gosubset_prok
synonym: "gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9]
xref: EC:3.4.19.9
xref: MetaCyc:3.4.19.9-RXN
is_a: GO:0008242 ! omega peptidase activity

[Term]
id: GO:0034723
name: DNA replication-dependent nucleosome organization
namespace: biological_process
def: "The formation or destruction of chromatin structures on newly replicated DNA, coupled to strand elongation." [GOC:mah, PMID:17510629]
synonym: "DNA replication-dependent nucleosome organisation" EXACT [GOC:curators]
is_a: GO:0006333 ! chromatin assembly or disassembly
is_a: GO:0034728 ! nucleosome organization

[Term]
id: GO:0034724
name: DNA replication-independent nucleosome organization
namespace: biological_process
def: "The formation or destruction of chromatin structures, occurring outside the context of DNA replication." [GOC:mah, PMID:17510629]
synonym: "DNA replication-independent nucleosome organisation" EXACT [GOC:curators]
is_a: GO:0006333 ! chromatin assembly or disassembly
is_a: GO:0034728 ! nucleosome organization

[Term]
id: GO:0034725
name: DNA replication-dependent nucleosome disassembly
namespace: biological_process
def: "The controlled breakdown of nucleosomes on newly replicated DNA, coupled to strand elongation." [GOC:mah, PMID:17510629]
is_a: GO:0006337 ! nucleosome disassembly
is_a: GO:0034723 ! DNA replication-dependent nucleosome organization

[Term]
id: GO:0034726
name: DNA replication-independent nucleosome disassembly
namespace: biological_process
def: "The controlled breakdown of nucleosomes outside the context of DNA replication." [GOC:mah, PMID:17510629]
is_a: GO:0006337 ! nucleosome disassembly
is_a: GO:0034724 ! DNA replication-independent nucleosome organization

[Term]
id: GO:0034727
name: piecemeal microautophagy of nucleus
namespace: biological_process
def: "Degradation of a cell nucleus by microautophagy." [GOC:jp, PMID:18701704]
synonym: "PMN" EXACT []
is_a: GO:0016237 ! microautophagy

[Term]
id: GO:0034728
name: nucleosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes." [GOC:mah]
synonym: "nucleosome organisation" EXACT [GOC:curators]
is_a: GO:0006325 ! chromatin organization
is_a: GO:0034621 ! cellular macromolecular complex subunit organization

[Term]
id: GO:0034729
name: histone H3-K79 methylation
namespace: biological_process
def: "The modification of histone H3 by addition of a methyl group to lysine at position 79 of the histone." [GOC:se]
synonym: "histone H3 K79 methylation" EXACT []
synonym: "histone H3K79me" EXACT []
synonym: "histone lysine H3 K79 methylation" EXACT []
is_a: GO:0034968 ! histone lysine methylation

[Term]
id: GO:0034730
name: SmD-containing SMN-Sm protein complex
namespace: cellular_component
def: "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex." [PMID:12975319, PMID:17401408]
synonym: "SMN-containing protein complex" BROAD []
is_a: GO:0034719 ! SMN-Sm protein complex

[Term]
id: GO:0034731
name: Lsm-containing SMN-Sm protein complex
namespace: cellular_component
def: "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D3, E, F, and G, and Lsm10 and Lsm11, with the SMN complex. This complex forms Sm cores on U7 snRNA." [PMID:12975319, PMID:17401408]
synonym: "SMN-containing protein complex" BROAD []
is_a: GO:0034719 ! SMN-Sm protein complex

[Term]
id: GO:0034732
name: transcription factor TFIIIB-alpha complex
namespace: cellular_component
def: "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and a specialized homolog of the conserved subunit BRF referred to as BRFU or TFIIIB50, which found in human but not conserved in yeast; the complex is involved in the regulation of transcription from type 3 (upstream) RNA polymerase III promoters." [PMID:11433012]
is_a: GO:0000126 ! transcription factor TFIIIB complex

[Term]
id: GO:0034733
name: transcription factor TFIIIB-beta complex
namespace: cellular_component
def: "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and BRF, and is involved in the regulation of transcription from type 2 RNA polymerase III promoters." [PMID:11433012]
comment: Note that the subunits of TFIIIB-beta are conserved between human and yeast; however, in yeast a single TFIIIB complex regulates transcription of tRNA, 5S rRNA and U6 snRNA genes, whereas two different TBP-dependent TFIIIB activities exist in humans.
is_a: GO:0000126 ! transcription factor TFIIIB complex

[Term]
id: GO:0034734
name: transcription factor TFIIIC1 complex
namespace: cellular_component
def: "A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity." [GOC:mah, PMID:11433012, PMID:15096501]
is_a: GO:0005667 ! transcription factor complex
relationship: part_of GO:0000127 ! transcription factor TFIIIC complex

[Term]
id: GO:0034735
name: transcription factor TFIIIC2 complex
namespace: cellular_component
def: "A transcription factor complex that forms part of the TFIIIC complex, observed in human; composed of five subunits (GTF3C1/hTFIIIC220/TFIIICalpha, GTF3C2/hTFIIIC110/TFIIICbeta, GTF3C3/hTFIIIC102/TFIIICgamma, GTF3C4/hTFIIIC90/TFIIICdelta and GTF3C5/hTFIIIC63/TFIIICepsilon in human) that together recognize the type 2 RNA polymerase III promoter." [GOC:mah, PMID:11433012]
is_a: GO:0005667 ! transcription factor complex
relationship: part_of GO:0000127 ! transcription factor TFIIIC complex

[Term]
id: GO:0034736
name: cholesterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + cholesterol = CoA + cholesterol ester." [EC:2.3.1.26]
synonym: "ACAT activity" BROAD [EC:2.3.1.26]
synonym: "acyl coenzyme A-cholesterol-O-acyltransferase activity" EXACT [EC:2.3.1.26]
synonym: "acyl-CoA:cholesterol acyltransferase activity" EXACT [EC:2.3.1.26]
synonym: "acyl-CoA:cholesterol O-acyltransferase activity" EXACT [EC:2.3.1.26]
synonym: "acylcoenzyme A:cholesterol O-acyltransferase activity" EXACT []
synonym: "cholesterol acyltransferase activity" BROAD [EC:2.3.1.26]
synonym: "cholesterol ester synthetase activity" EXACT [EC:2.3.1.26]
synonym: "cholesteryl ester synthetase activity" EXACT [EC:2.3.1.26]
xref: EC:2.3.1.26
xref: MetaCyc:STEROL-O-ACYLTRANSFERASE-RXN
is_a: GO:0004772 ! sterol O-acyltransferase activity

[Term]
id: GO:0034737
name: ergosterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester." [GOC:mah]
xref: EC:2.3.1.26
xref: MetaCyc:STEROL-O-ACYLTRANSFERASE-RXN
is_a: GO:0004772 ! sterol O-acyltransferase activity

[Term]
id: GO:0034738
name: lanosterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + lanosterol = CoA + lanosterol ester." [GOC:mah]
xref: EC:2.3.1.26
xref: MetaCyc:STEROL-O-ACYLTRANSFERASE-RXN
is_a: GO:0004772 ! sterol O-acyltransferase activity

[Term]
id: GO:0034739
name: histone deacetylase activity (H3-K16 specific)
namespace: molecular_function
def: "Catalysis of the removal of an acetyl group from lysine at position 16 of the histone H3 protein." [GOC:mah]
is_a: GO:0004407 ! histone deacetylase activity

[Term]
id: GO:0034740
name: TFIIIC-TOP1-SUB1 complex
namespace: cellular_component
def: "A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III." [PMID:9660958]
synonym: "TFIIIC-Topoisomerase 1-PC4 complex" EXACT []
is_a: GO:0005667 ! transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0034741
name: APC-tubulin-IQGAP1 complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), alpha-tubulin, gamma-tubulin, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization." [PMID:17126424]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
synonym: "60S APC complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034742
name: APC-Axin-1-beta-catenin complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), Axin-1, and beta-catenin." [PMID:16188939]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
synonym: "23S APC complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034743
name: APC-IQGAP complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC) and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0034744
name: APC-IQGAP1-Cdc42 complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0034745
name: APC-IQGAP1-Rac1 complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Rac1, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0034746
name: APC-IQGAP1-CLIP-170 complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and CLIP-170; may play a role in cytoskeleton organization and cell migration." [PMID:15572129]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0034747
name: Axin-APC-beta-catenin-GSK3B complex
namespace: cellular_component
def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), Axin-1, beta-catenin, and glycogen synthase kinase 3 beta. Formation of this complex leads to phosphorylation of beta-catenin and down-regulation of beta-catenin activity." [PMID:9601641]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034748
name: Par3-APC-KIF3A complex
namespace: cellular_component
def: "A protein complex that contains Par3, the tumor suppressor protein adenomatous polyposis coli (APC), and the kinesin-related protein KIF3A; involved in establishing neuronal cell polarity." [PMID:15556865]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034749
name: Scrib-APC complex
namespace: cellular_component
def: "A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation." [PMID:16611247]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
synonym: "hScrib-APC complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034750
name: Scrib-APC-beta-catenin complex
namespace: cellular_component
def: "A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation." [PMID:16611247]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
synonym: "hScrib-APC-beta-catenin complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034751
name: aryl hydrocarbon receptor complex
namespace: cellular_component
def: "A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497]
synonym: "AhR complex" EXACT []
synonym: "AHRC" EXACT []
is_a: GO:0043235 ! receptor complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0034752
name: cytosolic aryl hydrocarbon receptor complex
namespace: cellular_component
def: "An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP." [PMID:7598497, PMID:8937476, PMID:9447995]
synonym: "9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex" RELATED []
synonym: "cytosolic AhR complex" EXACT []
synonym: "cytosolic AHRC" EXACT []
is_a: GO:0034751 ! aryl hydrocarbon receptor complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0034753
name: nuclear aryl hydrocarbon receptor complex
namespace: cellular_component
def: "An aryl hydrocarbon receptor (AhR) complex found in the nucleus; ; consists of ligand-bound AhR and the aryl hydrocarbon receptor nuclear translocator (ARNT)." [PMID:7598497]
synonym: "6S-nuclear aryl hydrocarbon (Ah) receptor ligand-activated complex" RELATED []
synonym: "nuclear AhR complex" EXACT []
synonym: "nuclear AHRC" EXACT []
is_a: GO:0034751 ! aryl hydrocarbon receptor complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0034754
name: cellular hormone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells." [GOC:mah]
is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0034755
name: iron ion transmembrane transport
namespace: biological_process
def: "A process whereby an iron ion is transported from one side of a membrane to the other." [GOC:mah]
subset: gosubset_prok
synonym: "transmembrane iron transport" EXACT []
is_a: GO:0006826 ! iron ion transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0034756
name: regulation of iron ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "regulation of Fe transport" EXACT []
synonym: "regulation of iron transport" EXACT []
is_a: GO:0010959 ! regulation of metal ion transport
relationship: regulates GO:0006826 ! iron ion transport

[Term]
id: GO:0034757
name: negative regulation of iron ion transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of iron ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "down regulation of iron ion transport" EXACT []
synonym: "down-regulation of iron ion transport" EXACT []
synonym: "downregulation of iron ion transport" EXACT []
synonym: "inhibition of iron ion transport" NARROW []
synonym: "negative regulation of iron transport" EXACT []
is_a: GO:0034756 ! regulation of iron ion transport
is_a: GO:0043271 ! negative regulation of ion transport
relationship: negatively_regulates GO:0006826 ! iron ion transport

[Term]
id: GO:0034758
name: positive regulation of iron ion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
synonym: "activation of iron ion transport" NARROW []
synonym: "positive regulation of iron transport" EXACT []
synonym: "stimulation of iron ion transport" NARROW []
synonym: "up regulation of iron ion transport" EXACT []
synonym: "up-regulation of iron ion transport" EXACT []
synonym: "upregulation of iron ion transport" EXACT []
is_a: GO:0034756 ! regulation of iron ion transport
is_a: GO:0043270 ! positive regulation of ion transport
relationship: positively_regulates GO:0006826 ! iron ion transport

[Term]
id: GO:0034759
name: regulation of iron ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) from one side of a membrane to the other." [GOC:mah]
synonym: "regulation of transmembrane Fe transport" EXACT []
synonym: "regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of transmembrane iron transport" EXACT []
is_a: GO:0034756 ! regulation of iron ion transport
is_a: GO:0034765 ! regulation of ion transmembrane transport
relationship: regulates GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0034760
name: negative regulation of iron ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other." [GOC:mah]
synonym: "down regulation of transmembrane iron ion transport" EXACT []
synonym: "down-regulation of transmembrane iron ion transport" EXACT []
synonym: "downregulation of transmembrane iron ion transport" EXACT []
synonym: "inhibition of transmembrane iron ion transport" NARROW []
synonym: "negative regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of transmembrane iron transport" EXACT []
is_a: GO:0034757 ! negative regulation of iron ion transport
is_a: GO:0034759 ! regulation of iron ion transmembrane transport
is_a: GO:0034766 ! negative regulation of ion transmembrane transport
relationship: negatively_regulates GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0034761
name: positive regulation of iron ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other." [GOC:mah]
synonym: "activation of transmembrane iron ion transport" NARROW []
synonym: "positive regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of transmembrane iron transport" EXACT []
synonym: "stimulation of transmembrane iron ion transport" NARROW []
synonym: "up regulation of transmembrane iron ion transport" EXACT []
synonym: "up-regulation of transmembrane iron ion transport" EXACT []
synonym: "upregulation of transmembrane iron ion transport" EXACT []
is_a: GO:0034758 ! positive regulation of iron ion transport
is_a: GO:0034759 ! regulation of iron ion transmembrane transport
is_a: GO:0034767 ! positive regulation of ion transmembrane transport
relationship: positively_regulates GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0034762
name: regulation of transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0055085 ! transmembrane transport

[Term]
id: GO:0034763
name: negative regulation of transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]
synonym: "down regulation of transmembrane transport" EXACT []
synonym: "down-regulation of transmembrane transport" EXACT []
synonym: "downregulation of transmembrane transport" EXACT []
synonym: "inhibition of transmembrane transport" NARROW []
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0055085 ! transmembrane transport

[Term]
id: GO:0034764
name: positive regulation of transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah]
synonym: "activation of transmembrane transport" NARROW []
synonym: "stimulation of transmembrane transport" NARROW []
synonym: "up regulation of transmembrane transport" EXACT []
synonym: "up-regulation of transmembrane transport" EXACT []
synonym: "upregulation of transmembrane transport" EXACT []
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0055085 ! transmembrane transport

[Term]
id: GO:0034765
name: regulation of ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
synonym: "regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0034762 ! regulation of transmembrane transport
is_a: GO:0043269 ! regulation of ion transport
relationship: regulates GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0034766
name: negative regulation of ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
synonym: "down regulation of transmembrane ion transport" EXACT []
synonym: "down-regulation of transmembrane ion transport" EXACT []
synonym: "downregulation of transmembrane ion transport" EXACT []
synonym: "inhibition of transmembrane ion transport" NARROW []
synonym: "negative regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0034763 ! negative regulation of transmembrane transport
is_a: GO:0034765 ! regulation of ion transmembrane transport
is_a: GO:0043271 ! negative regulation of ion transport
relationship: negatively_regulates GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0034767
name: positive regulation of ion transmembrane transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah]
synonym: "activation of transmembrane ion transport" NARROW []
synonym: "positive regulation of transmembrane ion transport" EXACT []
synonym: "stimulation of transmembrane ion transport" NARROW []
synonym: "up regulation of transmembrane ion transport" EXACT []
synonym: "up-regulation of transmembrane ion transport" EXACT []
synonym: "upregulation of transmembrane ion transport" EXACT []
is_a: GO:0034764 ! positive regulation of transmembrane transport
is_a: GO:0034765 ! regulation of ion transmembrane transport
is_a: GO:0043270 ! positive regulation of ion transport
relationship: positively_regulates GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0034768
name: (E)-beta-ocimene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = (E)-beta-ocimene + diphosphate." [PMID:12624761]
xref: EC:4.2.3.15
xref: MetaCyc:RXN-5109
xref: MetaCyc:RXN-5110
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0034769
name: basement membrane disassembly
namespace: biological_process
def: "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion." [GOC:sart, PMID:17301221]
is_a: GO:0022617 ! extracellular matrix disassembly

[Term]
id: GO:0034770
name: histone H4-K20 methylation
namespace: biological_process
def: "The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of the histone." [GOC:mah]
synonym: "histone H4 K20 methylation" EXACT []
synonym: "histone H4K20me" EXACT []
synonym: "histone lysine H4 K20 methylation" EXACT []
is_a: GO:0034968 ! histone lysine methylation

[Term]
id: GO:0034771
name: histone H4-K20 monomethylation
namespace: biological_process
def: "The modification of histone H4 by addition of one methyl group to lysine at position 20 of the histone." [GOC:mah]
synonym: "histone H4 K20 monomethylation" EXACT []
synonym: "histone lysine H4 K20 monomethylation" EXACT []
is_a: GO:0018026 ! peptidyl-lysine monomethylation
is_a: GO:0034770 ! histone H4-K20 methylation

[Term]
id: GO:0034772
name: histone H4-K20 dimethylation
namespace: biological_process
def: "The modification of histone H4 by addition of two methyl groups to lysine at position 20 of the histone." [GOC:mah]
synonym: "histone H4 K20 dimethylation" EXACT []
synonym: "histone lysine H4 K20 dimethylation" EXACT []
is_a: GO:0018027 ! peptidyl-lysine dimethylation
is_a: GO:0034770 ! histone H4-K20 methylation

[Term]
id: GO:0034773
name: histone H4-K20 trimethylation
namespace: biological_process
def: "The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone." [GOC:mah]
synonym: "histone H4 K20 trimethylation" EXACT []
synonym: "histone lysine H4 K20 trimethylation" EXACT []
is_a: GO:0018023 ! peptidyl-lysine trimethylation
is_a: GO:0034770 ! histone H4-K20 methylation

[Term]
id: GO:0034774
name: secretory granule lumen
namespace: cellular_component
def: ": The volume enclosed by the membrane of a secretory granule." [GOC:rph]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0030141 ! secretory granule

[Term]
id: GO:0034775
name: glutathione transmembrane transport
namespace: biological_process
def: "A process whereby glutathinone is transported from one side of a membrane to the other." [GOC:mah]
synonym: "transmembrane glutathione transport" EXACT [GOC:dph, GOC:tb]
is_a: GO:0034635 ! glutathione transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0034776
name: response to histamine
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter." [ChEBI:18295, GOC:BHF, GOC:mah, GOC:vk]
synonym: "response to histamine stimulus" EXACT []
is_a: GO:0014075 ! response to amine stimulus

[Term]
id: GO:0034777
name: recycling endosome lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of a recycling endosome." [GOC:rph]
is_a: GO:0031904 ! endosome lumen
relationship: part_of GO:0055037 ! recycling endosome

[Term]
id: GO:0034778
name: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA = 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1003]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0636
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034779
name: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + H2O = 3-isopropenylpimelyl-CoA." [UM-BBD_reactionID:r1004]
xref: EC:3.7.1.-
xref: UM-BBD_enzymeID:e0637
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034780
name: glyphosate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyphosate + OH- = glyoxylate + aminomethylphosphonic acid (AMPA) + H+ + 2 e-." [UM-BBD_reactionID:r0073]
xref: EC:1.5.-.-
xref: UM-BBD_enzymeID:e0639
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0034781
name: N-cyclohexylformamide amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-cyclohexylformamide + OH- = cyclohexylamine + formate." [UM-BBD_reactionID:r1030]
xref: EC:3.5.1.-
xref: UM-BBD_enzymeID:e0640
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0034782
name: dimethylmalonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylmalonate + H+ = isobutyrate + CO2." [UM-BBD_reactionID:r1031]
xref: EC:4.1.1.-
xref: UM-BBD_enzymeID:e0641
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034783
name: pivalate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: pivalate + H+ + HSCoA + ATP = pivalyl-CoA + PPi + AMP." [UM-BBD_reactionID:r1032]
xref: EC:6.2.1.-
xref: UM-BBD_enzymeID:e0642
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034784
name: pivalyl-CoA mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: pivalyl-CoA = 3-methylbutyryl-CoA." [UM-BBD_reactionID:r1033]
xref: EC:5.4.99.-
xref: UM-BBD_enzymeID:e0643
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0034785
name: salicylate 5-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: salicylate + O2 + NAD(P)H + H+ = gentisate + H2O + NAD(P)+." [UM-BBD_reactionID:r1034]
xref: EC:1.14.13.-
xref: MetaCyc:RXN-10446
xref: UM-BBD_enzymeID:e0644
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034786
name: 9-fluorenone-3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-fluorenone + O2 + 2 H+ + 2 e- = 1-Hydro-1,1a-dihydroxy-9-fluorenone." [UM-BBD_reactionID:r1039]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0645
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034787
name: 1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydro-1,1a-dihydroxy-9-fluorenone + H2O = 2,3-dihydroxy-2'-carboxybiphenyl + 3 H+ + 2 e-." [UM-BBD_reactionID:r1040]
xref: EC:1.3.-.-
xref: UM-BBD_enzymeID:e0646
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034788
name: 2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxy-2'-carboxybiphenyl + O2 = 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H+." [UM-BBD_reactionID:r1041]
xref: EC:1.13.-.-
xref: UM-BBD_enzymeID:e0647
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0034789
name: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + phthalate + H+." [UM-BBD_reactionID:r1042]
xref: EC:3.7.1.-
xref: UM-BBD_enzymeID:e0648
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034790
name: 3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene = 3,4-dihydroxyfluorene + 2 H+ + 2 e-." [UM-BBD_reactionID:r1043]
xref: EC:1.3.1.-
xref: UM-BBD_enzymeID:e0649
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034791
name: isobutylamine N-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: isobutylamine + NADPH + O2 = isobutylhydroxylamine+ NADP+ + H2O." [UM-BBD_reactionID:r1053]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0656
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034792
name: hypophosphite dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hypophosphite + 2-oxoglutarate + O2 = succinate + phosphite + CO2." [UM-BBD_reactionID:r1058]
xref: EC:1.14.11.-
xref: UM-BBD_enzymeID:e0657
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0034793
name: cyclopropanecarboxylate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclopropanecarboxylate + CoASH = cyclopropanecarboxyl-CoA + OH-." [UM-BBD_reactionID:r1056]
xref: EC:6.2.1.-
xref: UM-BBD_enzymeID:e0659
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034794
name: cyclopropanecarboxyl-CoA decyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclopropanecarboxyl-CoA = crotonoyl-CoA." [UM-BBD_reactionID:r1057]
xref: EC:5.5.1.-
xref: UM-BBD_enzymeID:e0660
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0034795
name: butane monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexane + O2 + NAD(P)H + H+ = cyclohexanol + NAD(P)+ + H2O." [UM-BBD_reactionID:r1059]
xref: EC:1.14.15.-
xref: UM-BBD_enzymeID:e0661
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034796
name: adipate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: adipate + CoASH = adipyl-CoA + OH-." [UM-BBD_reactionID:r1060]
xref: EC:6.2.1.-
xref: UM-BBD_enzymeID:e0662
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034797
name: fosfomycin 2-glutathione ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + glutathione = hydrogen (1R,2R)-1-glutathio-2-hydroxypropylphosphonic acid." [UM-BBD_reactionID:r1073]
xref: EC:6.2.-.-
xref: UM-BBD_enzymeID:e0665
is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds

[Term]
id: GO:0034798
name: fosfomycin 2-L-cysteine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + L-cysteine = hydrogen (1R,2R)-1- L-cysteine-2-hydroxypropylphosphonic acid." [UM-BBD_reactionID:r1074]
xref: EC:6.2.-.-
xref: UM-BBD_enzymeID:e0666
is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds

[Term]
id: GO:0034799
name: dihydride TNP tautomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = TNP dihydride Meisenheimer complex (nitro form)." [UM-BBD_reactionID:r1070]
xref: EC:5.3.2.-
xref: UM-BBD_enzymeID:e0669
is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups

[Term]
id: GO:0034800
name: TNP dihydride denitratase activity
namespace: molecular_function
def: "Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = 2,4-DNP hydride Meisenheimer complex + NO2." [UM-BBD_reactionID:r1067]
xref: EC:1.7.99.-
xref: UM-BBD_enzymeID:e0670
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0034801
name: 2,4-dinitrocyclohexanone hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dinitrocyclohexanone + OH- = 4,6-dinitrohexanoate." [UM-BBD_reactionID:r1069]
xref: EC:3.7.1.-
xref: UM-BBD_enzymeID:e0671
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034802
name: branched-chain dodecylbenzene sulfonate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: branched-chain dodecylbenzene sulfonate + 1/2 O2 + H+ = sulfurous acid + branched-chain dodecyl-4-hydroxy-benzene + (SO3)2-." [UM-BBD_reactionID:r1079]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0672
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034803
name: 3-hydroxy-2-naphthoate 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-naphthoate + O2 = (3E)-3-[(6Z)-6-(carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate." [UM-BBD_reactionID:r1104]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0678
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034804
name: benzo(a)pyrene 11,12-epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-11,12-epoxide." [UM-BBD_reactionID:r1119]
xref: EC:1.14.99.-
xref: UM-BBD_enzymeID:e0688
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034805
name: benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzo(a)pyrene-trans-11,12-dihydrodiol = 11,12-dihydroxybenzo(a)pyrene + 2 H+ + 2 e-." [UM-BBD_reactionID:r1121]
xref: EC:1.3.1.-
xref: UM-BBD_enzymeID:e0689
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034806
name: benzo(a)pyrene 11,12-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-11,12-dihydrodiol." [UM-BBD_reactionID:r1124]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0692
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034807
name: 4,5-dihydroxybenzo(a)pyrene methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + C1 unit = hydroxymethoxybenzo(a)pyrene." [UM-BBD_reactionID:r1131]
xref: EC:2.1.1.-
xref: UM-BBD_enzymeID:e0694
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0034808
name: benzo(a)pyrene 4,5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-4,5-dihydrodiol." [UM-BBD_reactionID:r1126]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0695
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034809
name: benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzo(a)pyrene-cis-4,5-dihydrodiol = 4,5-dihydroxybenzo(a)pyrene + H2." [UM-BBD_reactionID:r1127]
xref: EC:1.3.1.-
xref: UM-BBD_enzymeID:e0696
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034810
name: 4,5-dihydroxybenzo(a)pyrene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + O2 = 4,5-chrysenedicarboxylate." [UM-BBD_reactionID:r1128]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0697
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034811
name: benzo(a)pyrene 9,10-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-9,10-dihydrodiol." [UM-BBD_reactionID:r1132]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0700
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034812
name: 9,10-dihydroxybenzo(a)pyrene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9,10-dihydroxybenzo(a)pyrene + O2 = cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r1134]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0702
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034813
name: benzo(a)pyrene 7,8-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-7,8-dihydrodiol." [UM-BBD_reactionID:1137]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0703
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034814
name: 7,8-dihydroxy benzo(a)pyrene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzo(a)pyrene-cis-7,8-dihydrodiol + O2 = cis-4-(7-hydroxypyren-8-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r1138]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0704
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034815
name: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate = 10-Oxabenzo(def)chrysen-9-one + formate + H+." [UM-BBD_reactionID:r1135]
xref: EC:4.1.3.-
xref: UM-BBD_enzymeID:e0706
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0034816
name: anthracene 9,10-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthracene + 2 H2O = cis-9,10-dihydroanthracene-9,10-diol." [UM-BBD_reactionID:r1141]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0707
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034817
name: cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-9,10-dihydroanthracene-9,10-diol = 9,10-anthraquinone + 4 H+ + 4 e-." [UM-BBD_reactionID:r1144]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0708
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034818
name: ADD 9alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: androsta-1,4-diene-3,17-dione + reduced ferredoxin + O2 = 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + oxidized ferredoxin." [UM-BBD_reactionID:r1149]
xref: EC:1.14.15.-
xref: UM-BBD_enzymeID:e0713
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034819
name: 3-HSA hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADPH + H+ + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADP+ + H2O." [UM-BBD_reactionID:r1150]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0714
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034820
name: 4,9-DSHA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3E,1Z)-4,5-9,10-Diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate + H2O = (2E,4E)-2-hydroxyhexa-2,4-dienoate + 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + H+." [UM-BBD_reactionID:r1152]
xref: EC:3.7.1.-
xref: UM-BBD_enzymeID:e0716
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034821
name: citronellol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: citronellol + NAD+ = citronellal + NADH + H+." [UM-BBD_reactionID:r1155]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0717
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034822
name: citronellal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: citronellal + NAD+ + OH- = citronellate + NADH + H+." [UM-BBD_reactionID:r1156]
xref: EC:1.2.1.-
xref: UM-BBD_enzymeID:e0718
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034823
name: citronellyl-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi." [UM-BBD_reactionID:r1157]
xref: EC:6.2.1.-
xref: UM-BBD_enzymeID:e0719
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034824
name: citronellyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: citronellyl-CoA + NAH+ = cis-geranyl-CoA + NADH + H+." [UM-BBD_reactionID:r1159]
xref: EC:1.3.1.-
xref: UM-BBD_enzymeID:e0720
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034825
name: tetralin ring-hydroxylating dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tetralin + O2 + NADH + H+ = cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+." [UM-BBD_reactionID:r1169]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0727
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0034826
name: 1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+." [UM-BBD_reactionID:r1170]
xref: EC:1.3.-.-
xref: UM-BBD_enzymeID:e0728
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034827
name: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + O2 = 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H+." [UM-BBD_reactionID:r1171]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0729
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034828
name: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H2O = 2-hydroxydec-2,4-diene-1,10-dioate + H+." [UM-BBD_reactionID:r1172]
xref: EC:3.7.1.-
xref: UM-BBD_enzymeID:e0730
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034829
name: 2-hydroxydec-2,4-diene-1,10-dioate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxydec-2,4-diene-1,10-dioate + H2O = (2Z)-2,4-dihydroxydec-2-enedioate." [UM-BBD_reactionID:r1172]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0731
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034830
name: (2Z)-2,4-dihydroxydec-2-enedioate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2Z)-2,4-dihydroxydec-2-enedioate = pyruvate + 7-oxoheptanoate." [UM-BBD_reactionID:r1174]
xref: EC:4.1.3.-
xref: UM-BBD_enzymeID:e0732
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0034831
name: (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-1,2,3,4-tetrahydronaphthol = 1,2,3,4-tetrahydronaphthalone + 2 H+ + 2 e-." [UM-BBD_reactionID:r1176]
xref: EC:1.1.1.-
xref: UM-BBD_enzymeID:e0733
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034832
name: geranial dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranial + NAD+ + OH- = geranylate + NADH + H+." [UM-BBD_reactionID:r1164]
xref: EC:1.2.1.-
xref: UM-BBD_enzymeID:e0735
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034833
name: geranylate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylate + CoASH = trans-geranyl-CoA + OH-." [UM-BBD_reactionID:r1165]
xref: EC:2.8.3.-
xref: UM-BBD_enzymeID:e0736
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0034834
name: 2-mercaptobenzothiazole dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-mercaptobenzothiazole + O2 + 2 H+ + 2 e- = 2-mercaptobenzothiazole-cis-6,7-dihydrodiol ." [UM-BBD_reactionID:r1177]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0737
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034835
name: 2-mercaptobenzothiazole monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-mercaptobenzothiazole + 1/2 O2 = 6-hydroxy-2-mercaptobenzothiazole." [UM-BBD_reactionID:r1178]
xref: EC:1.13.12.-
xref: UM-BBD_enzymeID:e0738
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0034836
name: 6-hydroxy-2-mercaptobenzothiazole monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxy-2-mercaptobenzothiazole + 1/2 O2 = 6,7-dihydroxy-2-mercaptobenzothiazole." [UM-BBD_reactionID:r1181]
xref: EC:1.13.12.-
xref: UM-BBD_enzymeID:e0739
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0034837
name: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol = 6,7-dihydroxy-2-mercaptobenzothiazole + 2 H+ + 2 e-." [UM-BBD_reactionID:r1179]
xref: EC:1.3.-.-
xref: UM-BBD_enzymeID:e0740
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034838
name: menthone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-(2S,5R)-menthone + NAD+ = (5R)-menth-2-enone + NADH + H+." [UM-BBD_reactionID:r1183]
xref: EC:1.3.1.-
xref: UM-BBD_enzymeID:e0742
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034839
name: menth-2-enone hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5R)-menth-2-enone + H2O = (5R)-3-hydroxymenthone." [UM-BBD_reactionID:r1184]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0743
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034840
name: 3-hydroxymenthone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5R)-3-hydroxymenthone + NAD+ = mentha-1,3-dione + NADH + H+." [UM-BBD_reactionID:r1185]
xref: EC:1.1.1.-
xref: UM-BBD_enzymeID:e0744
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034841
name: mentha-1,3-dione-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: mentha-1,3-dione + CoASH = 3,7-dimethyl-5-oxo-octyl-CoA." [UM-BBD_reactionID:r1186]
xref: EC:6.2.1.-
xref: UM-BBD_enzymeID:e0745
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034842
name: thiophene-2-carboxylate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiophene-2-carboxylate + ATP + CoASH = thiophene-2-carboxyl-CoA - AMP + PPi." [UM-BBD_reactionID:r1234]
xref: EC:6.2.1.-
xref: UM-BBD_enzymeID:e0774
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034843
name: 2-oxoglutaryl-CoA thioesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutaryl-CoA + OH- = 2-oxoglutarate + CoASH." [UM-BBD_reactionID:r1238]
xref: EC:3.1.2.-
xref: UM-BBD_enzymeID:e0778
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0034844
name: naphthyl-2-methyl-succinate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: naphthyl-2-methyl-succinate + succinyl-CoA = naphthyl-2-methyl-succinyl-CoA + succinate." [UM-BBD_reactionID:r1256]
xref: EC:2.8.3.-
xref: UM-BBD_enzymeID:e0784
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0034845
name: naphthyl-2-methyl-succinyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: naphthyl-2-methyl-succinyl-CoA = naphthyl-2-methylene-succinyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1258]
xref: EC:1.3.99.-
xref: UM-BBD_enzymeID:e0785
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034846
name: naphthyl-2-methylene-succinyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: naphthyl-2-methylene-succinyl-CoA + H2O = naphthyl-2-hydroxymethyl-succinyl-CoA." [UM-BBD_reactionID:r1259]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0786
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034847
name: naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: naphthyl-2-hydroxymethyl-succinyl-CoA = naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1260]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0787
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034848
name: naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: naphthyl-2-oxomethyl-succinyl-CoA + CoASH = 2-naphthoyl-CoA + succinyl-CoA." [UM-BBD_reactionID:r1261]
xref: EC:2.3.1.-
xref: UM-BBD_enzymeID:e0788
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0034849
name: 2-naphthoate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-naphthoyl-CoA + OH- = 2-naphthoate + CoASH." [UM-BBD_reactionID:r1262]
xref: EC:2.8.3.-
xref: UM-BBD_enzymeID:e0789
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0034850
name: isooctane monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: isooctane + 1/2 O2 = 2,4,4-trimethyl-1-pentanol." [UM-BBD_reactionID:r1269]
xref: EC:1.13.12.-
xref: UM-BBD_enzymeID:e0795
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0034851
name: 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + CoASH = pivalyl-CoA + propanoyl-CoA." [UM-BBD_reactionID:r1274]
xref: EC:2.3.1.-
xref: UM-BBD_enzymeID:e0800
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0034852
name: 4,4-dimethyl-3-oxopentanal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,4-dimethyl-3-oxopentanal + H2O = 4,4-dimethyl-3-oxopentanoate + 3 H+ + 2 e-." [UM-BBD_reactionID:r1309]
xref: EC:1.2.-.-
xref: UM-BBD_enzymeID:e0801
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0034853
name: 2,4,4-trimethyl-3-oxopentanoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoate + H+ = 2,2-dimethyl-3-pentanone + CO2." [UM-BBD_reactionID:r1278]
xref: EC:4.1.1.-
xref: UM-BBD_enzymeID:e0804
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034854
name: 4,4-dimethyl-3-oxopentanoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,4-dimethyl-3-oxopentanoate + H+ = 3,3-dimethyl-2-butanone + CO2." [UM-BBD_reactionID:r1280]
xref: EC:4.1.1.-
xref: UM-BBD_enzymeID:e0806
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034855
name: 4-AD 9alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: androst-4-ene-3,17-dione + O2 + 2 H+ + 2 e- = 9alpha-hydroxy-4-androstene-3,17-dione + H2O." [UM-BBD_reactionID:r1153]
xref: EC:1.14.15.-
xref: UM-BBD_enzymeID:e0807
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034856
name: 2-hydroxyhexa-2,4-dienoate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2E,4E)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate." [UM-BBD_reactionID:r1281]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0809
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034857
name: 2-(methylthio)benzothiazole monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(methylthio)benzothiazole + 1/2 O2 = 2-(methylsulfinyl)benzothiazole." [UM-BBD_reactionID:r1287]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0810
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034858
name: 2-hydroxybenzothiazole monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxybenzothiazole + 1/2 O2 = 2,6-dihydroxybenzothiazole." [UM-BBD_reactionID:r1291]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0811
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034859
name: benzothiazole monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzothiazole + 1/2 O2 = 2-hydroxybenzothiazole." [UM-BBD_reactionID:r1292]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0812
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034860
name: 2-mercaptobenzothiazole desulfurase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-mercaptobenzothiazole + reduced acceptor = benzothiazole + H2S + oxidized acceptor." [UM-BBD_reactionID:r1288]
xref: EC:4.4.1.-
xref: UM-BBD_enzymeID:e0813
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0034861
name: benzothiazole-2-sulfonate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzothiazole-2-sulfonate + H2O = 2-hydroxybenzothiazole + SO3H-." [UM-BBD_reactionID:r1290]
xref: EC:3.13.1.-
xref: UM-BBD_enzymeID:e0814
is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds

[Term]
id: GO:0034862
name: 2,6-dihydroxybenzothiazole monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dihydroxybenzothiazole + 1/2 O2 = 2,6,7-trihydroxybenzothiazole." [UM-BBD_reactionID:r1294]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0815
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034863
name: 2,4,4-trimethyl-1-pentanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethyl-1-pentanol = 2,4,4-trimethylpentanal+ 2 H+ + 2 e-." [UM-BBD_reactionID:r1270]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0816
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034864
name: 2,4,4-trimethylpentanal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethylpentanal + H2O = 2,4,4-trimethylpentanoate + 3 H+ + 2 e-." [UM-BBD_reactionID:r1275]
xref: EC:1.2.-.-
xref: UM-BBD_enzymeID:e0817
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0034865
name: 2,4,4-trimethylpentanoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethylpentanoate + CoASH = 2,4,4-trimethylpentanoyl-CoA + OH-." [UM-BBD_reactionID:r1271]
xref: EC:6.2.1.-
xref: UM-BBD_enzymeID:e0818
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034866
name: 2,4,4-trimethylpentanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethylpentanoyl-CoA = 2,4,4-trimethylpent-2-enoyl-CoA + 2 H+ + 2e-." [UM-BBD_reactionID:r1276]
xref: EC:1.3.-.-
xref: UM-BBD_enzymeID:e0819
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034867
name: 2,4,4-trimethylpent-2-enoyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethylpent-2-enoyl-CoA + H2O = 2,4,4-trimethyl-3-hydroxypentanoyl-CoA." [UM-BBD_reactionID:r1277]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0820
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034868
name: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA = 2,4,4-trimethyl-3-oxopentanoyl-CoA + 2 H+ + 2 e- ." [UM-BBD_reactionID:r1273]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0821
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034869
name: 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + OH- = 2,4,4-trimethyl-3-oxopentanoate + CoASH." [UM-BBD_reactionID:r1307]
xref: EC:3.1.2.-
xref: UM-BBD_enzymeID:e0822
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0034870
name: pinacolone 5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,2-dimethyl-3-pentanone + 1/2 O2 = 1-hydroxy-4,4-dimethylpentan-3-one." [UM-BBD_reactionID:r12979]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0823
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034871
name: 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxy-4,4-dimethylpentan-3-one = 4,4-dimethyl-3-oxopentanal + 2 H+ + 2 e-." [UM-BBD_reactionID:r1308]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0824
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034872
name: trans-geranyl-CoA isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-geranyl-CoA = cis-geranyl-CoA." [UM-BBD_reactionID:r1310]
xref: EC:5.2.1.-
xref: UM-BBD_enzymeID:e0825
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0034873
name: thioacetamide S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: thioacetamide +O2 + 2 H+ + 2 e- = thioacetamide S-oxide + H2O." [UM-BBD_reactionID:r1312]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0826
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034874
name: thioacetamide S-oxide S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: thioacetamide S-oxide + O2 + 2 H+ + 2 e- = thioacetamide S,S-dioxide + H2O." [UM-BBD_reactionID:r1313]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0827
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034875
name: caffeine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O." [UM-BBD_reactionID:r1321]
xref: EC:1.17.5.-
xref: UM-BBD_enzymeID:e0831
is_a: GO:0033695 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor

[Term]
id: GO:0034876
name: isonicotinic acid hydrazide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: isoniazid + H2O = isonicotinate + hydrazine." [UM-BBD_reactionID:r1336]
xref: EC:3.5.1.-
xref: UM-BBD_enzymeID:e0833
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0034877
name: isonicotinate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: isonicotinate + acceptor + H2O = 2-hydroxyisonicotinate + reduced acceptor." [UM-BBD_reactionID:r1337]
xref: EC:1.15.-.-
xref: UM-BBD_enzymeID:e0835
is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor

[Term]
id: GO:0034878
name: 2-hydroxyisonicotinate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyisonicotinate + acceptor + H2O = citrazinate + reduced acceptor." [UM-BBD_reactionID:r1338]
xref: EC:1.15.-.-
xref: UM-BBD_enzymeID:e0836
is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor

[Term]
id: GO:0034879
name: 2,3,6-trihydroxyisonicotinate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3,6-trihydroxyisonicotinate = 2,3,6-trihydroxypyridine + CO2." [UM-BBD_reactionID:r1340]
xref: EC:4.1.1.-
xref: UM-BBD_enzymeID:e0837
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034880
name: citrazinate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: citrazinate + H2O = 2,3,6-trihydroxyisonicotinate + 2 H+ + 2 e-." [UM-BBD_reactionID:r1339]
xref: EC:1.15.-.-
xref: UM-BBD_enzymeID:e0838
is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor

[Term]
id: GO:0034881
name: citrazinate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: citrazinate + H2O = cis-aconitamide." [UM-BBD_reactionID:r1343]
xref: EC:3.5.2.-
xref: UM-BBD_enzymeID:e0839
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0034882
name: cis-aconitamide amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-aconitamide + H2O = cis-aconitate + HN3." [UM-BBD_reactionID:r1344]
xref: EC:3.5.1.-
xref: UM-BBD_enzymeID:e0840
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0034883
name: isonicotinate reductase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: isonicotinate + 2 H+ + 2 e- = 1,4-dihydroisonicotinate." [UM-BBD_reactionID:r1347]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
xref: EC:1.3.-.-
xref: UM-BBD_enzymeID:e0841
is_obsolete: true
consider: GO:0016627

[Term]
id: GO:0034884
name: gamma-N-formylaminovinylacetaldehyde dehydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: gamma-N-formylaminovinylacetaldehyde + H2O = gamma-N-formylaminovinylacetate + 2 H+ + 2 e-." [UM-BBD_reactionID:r1349]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
xref: EC:1.2.99.-
xref: UM-BBD_enzymeID:e0842
is_obsolete: true
consider: GO:0016903

[Term]
id: GO:0034885
name: gamma-N-formylaminovinylacetate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: gamma-N-formylaminovinylacetate + h@O = gamma-aminovinylacetate+ HCOOH." [UM-BBD_reactionID:r1350]
xref: EC:3.5.1.-
xref: UM-BBD_enzymeID:e0843
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0034886
name: gamma-aminovinylacetate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: gamma-aminovinylacetate + H2O = succinic semialdehyde + NH3." [UM-BBD_reactionID:r1351]
xref: EC:3.5.99.-
xref: UM-BBD_enzymeID:e0844
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0034887
name: 1,4-dihydroisonicotinate 2,3-dioxygenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 1,4-dihydroisonicotinate + O2 = gamma-N-formylaminovinylacetaldehyde + CO2." [UM-BBD_reactionID:r1348]
comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity.
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0845
is_obsolete: true
consider: GO:0016702

[Term]
id: GO:0034888
name: endosulfan monooxygenase I activity
namespace: molecular_function
def: "Catalysis of the reaction: endosulfan + O2 + 2 H+ + 2 e- = endosulfan sulfate + H2O." [UM-BBD_reactionID:r1382]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0856
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034889
name: endosulfan hemisulfate sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: endosulfan hemisulfate + H2O = endosulfan monoalcohol + 2 H+ + SO4." [UM-BBD_reactionID:r1384]
xref: EC:3.1.6.-
xref: UM-BBD_enzymeID:e0858
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0034890
name: endosulfan diol hydrolyase (cyclizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: endosulfan diol = endosulfan ether + H2O." [UM-BBD_reactionID:r1386]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0860
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034891
name: endosulfan diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: endosulfan diol = endosulfan hydroxyether + 2 H+ + 2 e-." [UM-BBD_reactionID:r1388]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0861
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034892
name: endosulfan lactone lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: endosulfan lactone + H2O = endosulfan hydroxycarboxylate + H+." [UM-BBD_reactionID:r1389]
xref: EC:3.1.1.-
xref: UM-BBD_enzymeID:e0862
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0034893
name: N-nitrodimethylamine hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-nitrodimethylamine + O2 + 2 H+ + 2 e- = N-nitromethylamine + formaldehyde + H2O." [UM-BBD_reactionID:r1395]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0864
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034894
name: 4-hydroxypyridine-3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxypyridine + O2 + H+ + NADPH = pryidine-3,4-diol + H2O + NAHP+." [UM-BBD_reactionID:r1397]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0865
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034895
name: pyridine-3,4-diol dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pryidine-3,4-diol + O2 = 3-(N-formyl)-formiminopyruvate." [UM-BBD_reactionID:r1398]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0866
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034896
name: 3-formiminopyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-formiminopyruvate + H2O = 3-formylpyruvate + HN3." [UM-BBD_reactionID:r1400]
xref: EC:3.5.99.-
xref: UM-BBD_enzymeID:e0867
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0034897
name: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol + O2 + 2 H+ + 2 e- = hydroquinone + 3,6-dimethylheptan-3-ol." [UM-BBD_reactionID:r1358]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0869
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034898
name: hexadecyltrimethylammonium chloride monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexadecyltrimethylammonium chloride + NAD(P)H + H+ + O2 = trimethylamine + hexadecanal + NAD(P)+ + H2O." [UM-BBD_reactionID:r1373]
xref: EC:1.13.12.-
xref: UM-BBD_enzymeID:e0872
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0034899
name: trimethylamine monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trimethylamine + NADH + H+ + O2 = trimethylamine N-oxide + NAD+ + H2O." [UM-BBD_reactionID:r1407]
xref: EC:1.14.13.-
xref: UM-BBD_enzymeID:e0873
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034900
name: 3-(N-formyl)-formiminopyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(N-formyl)-formiminopyruvate + H2O = 3-formiminopyruvate + formate." [UM-BBD_reactionID:r1399]
xref: EC:3.5.99.-
xref: UM-BBD_enzymeID:e0888
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0034901
name: endosulfan hydroxyether dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: endosulfan hydroxyether = endosulfan lactone + 2 H+ + 2 e-." [UM-BBD_reactionID:r1411]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0894
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034902
name: endosulfan sulfate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: endosulfan sulfate + H2O = endosulfan diol + SO3." [UM-BBD_reactionID:r1387]
xref: EC:3.1.6.-
xref: UM-BBD_enzymeID:e0895
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0034903
name: endosulfan ether monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: endosulfan ether + O2 + 2 H+ + 2 e- = endosulfan hydroxyether + H2O." [UM-BBD_reactionID:r1413]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0897
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034904
name: 5-chloro-2-oxopent-4-enoate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-chloro-2-oxopent-4-enoate + H2O = 5-chloro-4-hydroxy-2-oxopentanate." [UM-BBD_reactionID:r1436]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0906
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034905
name: 5-chloro-4-hydroxy-2-oxopentanate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde." [UM-BBD_reactionID:r1437]
xref: EC:4.1.3.-
xref: UM-BBD_enzymeID:e0907
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0034906
name: N-isopropylaniline 1,2-dixoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-isopropylaniline + O2 + 2 H+ + NADH = catechol + NAD+ + isopropylamine." [UM-BBD_reactionID:r0721]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0908
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0034907
name: acetanilide 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetanilide + O2 + 2 H+ + NADH = catechol + NAD+ + acetamide." [UM-BBD_reactionID:r0723]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0909
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0034908
name: 2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + O2 + 2 H+ + NADH = 2-chloro-N-isopropylacetamide + catechol + NAD+." [UM-BBD_reactionID:r0724]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0910
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0034909
name: 6-hydroxypseudooxynicotine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 E- + NH2CH3." [UM-BBD_reactionID:r1441]
xref: EC:1.5.-.-
xref: UM-BBD_enzymeID:e0912
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0034910
name: 6-hydroxy-3-succinoylpyridine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxy-3-succinoylpyridine + H2O = succinic semialdehyde + 2,5-dihydroxypyridine." [UM-BBD_reactionID:r1442]
xref: EC:3.7.1.-
xref: UM-BBD_enzymeID:e0913
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034911
name: phthalate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phthalate + O2 + NADH + H+ = phthalate 3,4-cis-dihydrodiol+ NAD+." [UM-BBD_reactionID:r1444]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0914
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0034912
name: phthalate 3,4-cis-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+." [UM-BBD_reactionID:r1445]
xref: EC:1.3.1.-
xref: MetaCyc:RXN5F9-56
xref: UM-BBD_enzymeID:e0915
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0034913
name: 3,4-dihydroxyphthalate 2-decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxyphthalate + H+ = 3,4-dihydroxybenzoate + CO2." [UM-BBD_reactionID:r1447]
xref: EC:4.1.1.-
xref: MetaCyc:34-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN
xref: UM-BBD_enzymeID:e0917
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034914
name: TNP hydride denitratase activity
namespace: molecular_function
def: "Catalysis of the reaction: TNP hydride Meisenheimer complex = 2,4-dinitrophenol + NO2-." [UM-BBD_reactionID:r1448]
xref: EC:1.7.99.-
xref: UM-BBD_enzymeID:e0921
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0034915
name: 2-methylhexanoyl-CoA C-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methyl-3-oxooctanoyl-CoA + CoA = acetyl-CoA + 2-methylhexanoyl-CoA." [UM-BBD_reactionID:r0927]
xref: EC:2.3.1.-
xref: UM-BBD_enzymeID:e0580
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0034916
name: 2-methylhexanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylhexanoyl-CoA = 2-methylhex-2-enoyl-CoA + 2 H+ + e-." [UM-BBD_reactionID:r0928]
xref: EC:1.3.99.-
xref: UM-BBD_enzymeID:e0581
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034917
name: 2-methylhex-2-enoyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylhex-2-enoyl-CoA + H2O = 3-hydroxy-2-methylhexanoyl-CoA." [UM-BBD_reactionID:r0929]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0582
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034918
name: 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-methylhexanoyl-CoA = 2-methyl-3-oxohexanoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0930]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0583
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034919
name: butyryl-CoA 2-C-propionyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-3-oxohexanoyl-CoA + CoA = propanoyl-CoA + butyryl-CoA." [UM-BBD_reactionID:r0931]
xref: EC:2.3.1.-
xref: UM-BBD_enzymeID:e0584
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0034920
name: pyrene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pryene + 2 H+ + 2 e- + O2 = cis-4,5-dihydroxy-4,5-dihydropyrene." [UM-BBD_reactionID:r0934]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0585
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034921
name: cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-4,5-dihydroxy-4,5-dihydropyrene = 4,5-dihydroxypyrene + 2 H+ + 2 e-." [UM-BBD_reactionID:r0935]
xref: EC:1.3.-.-
xref: UM-BBD_enzymeID:e0586
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034922
name: 4,5-dihydroxypyrene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,5-dihydroxypyrene + O2 = phenanthrene-4,5-dicarboxylate + 2 H+." [UM-BBD_reactionID:r0936]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0587
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034923
name: phenanthrene-4,5-dicarboxylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene-4,5-dicarboxylate + H+ = phenanthrene-4-carboxylate + CO2." [UM-BBD_reactionID:r0937]
xref: EC:4.1.1.-
xref: UM-BBD_enzymeID:e0588
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034924
name: cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-3,4-phenanthrenedihydrodiol-4-carboxylate = 3,4-dihydroxyphenanthrene + H+ + 2 e- + CO2." [UM-BBD_reactionID:r0940]
xref: EC:1.3.-.-
xref: UM-BBD_enzymeID:e0589
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0034925
name: pyrene 4,5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pryene + O2 + 2 H+ + 2 e- = pryene-4,5-oxide + H2O." [UM-BBD_reactionID:r0941]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0590
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034926
name: pyrene-4,5-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: pryene-4,5-oxide + H2O = trans-4,5-dihydroxy-4,5-dihydropyrene." [UM-BBD_reactionID:r0942]
xref: EC:3.3.2.-
xref: UM-BBD_enzymeID:e0591
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0034927
name: pyrene 1,2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pryene + O2 + 2 H+ + 2 e- = pryene-1,2-oxide + H2O." [UM-BBD_reactionID:r0943]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0592
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034928
name: 1-hydroxypyrene 6,7-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-6,7-oxide + H2O." [UM-BBD_reactionID:r0946]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0594
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034929
name: 1-hydroxypyrene 7,8-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxypyrene +O2 + 2 H+ + 2 e- = 1-hydroxypyrene-7,8-oxide + H2O." [UM-BBD_reactionID:r0949]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0596
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034930
name: 1-hydroxypyrene sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxypyrene + XSO3- = 1-pryenylsulfate + HX." [UM-BBD_reactionID:r0952]
xref: EC:2.8.2.-
xref: UM-BBD_enzymeID:e0598
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0034931
name: 1-hydroxypyrene methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxypyrene + XCH3 = 1-methoxypyrene + HX." [UM-BBD_reactionID:r0953]
xref: EC:2.1.1.-
xref: UM-BBD_enzymeID:e0599
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0034932
name: 1-methoxypyrene 6,7-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-methoxypyrene + O2 + 2 H+ + 2 e- = 1-methoxypyrene-6,7-oxide + H2O." [UM-BBD_reactionID:r0954]
xref: EC:1.4.-.-
xref: UM-BBD_enzymeID:e0600
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0034933
name: 1-hydroxy-6-methoxypyrene methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-hydroxy-6-methoxypyrene + XCH3 = 1,6-dimethoxypyrene + HX." [UM-BBD_reactionID:r0956]
xref: EC:2.1.1.-
xref: UM-BBD_enzymeID:e0602
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0034934
name: phenanthrene-4-carboxylate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenanthrene-4-carboxylate + 2 H+ + 2 e- + O2 = cis-3,4-phenanthrenedihydrodiol-4-carboxylate." [UM-BBD_reactionID:r0939]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0603
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034935
name: tetrachlorobenzene dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dichlorotoluene + NADH + H+ + O2 = 4,6-dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+." [UM-BBD_reactionID:r0957]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0604
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034936
name: 4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,6-dichloro-3-methylcatechol + O2 = 3,5-dichloro-3-methyl-cis,cis-muconate + 2 H+." [UM-BBD_reactionID:r0959]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0605
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034937
name: perchlorate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: perchlorate + 2 H+ + 2 e- = chlorate + H2O." [UM-BBD_reactionID:r0980]
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0608
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034938
name: pyrrole-2-carboxylate monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pryrole-2-carboxylate + NADH + O2 + H+ = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O." [UM-BBD_reactionID:r0968]
xref: EC:1.14.14.-
xref: UM-BBD_enzymeID:e0611
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0034939
name: 5-hydroxypyrrole-2-carboxylate tautomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxypyrrole-2-carboxylate = 5-oxo-4,5-dihydropyrrole-2-carboxylate." [UM-BBD_reactionID:r0969]
xref: EC:5.3.2.-
xref: UM-BBD_enzymeID:e0612
is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups

[Term]
id: GO:0034940
name: 5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-oxo-4,5-dihydropyrrole-2-carboxylate + 2 H2O = 2-oxoglutarate + NH3." [UM-BBD_reactionID:r0984]
xref: EC:3.5.2.-
xref: UM-BBD_enzymeID:e0613
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0034941
name: pyrrole-2-carboxylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: pryrole-2-carboxylate + H+ = pyrrole + CO2." [UM-BBD_reactionID:r0970]
xref: EC:4.1.1.-
xref: UM-BBD_enzymeID:e0614
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034942
name: cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = cis-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi." [UM-BBD_reactionID:r0988]
xref: EC:6.2.1.-
xref: UM-BBD_enzymeID:e0616
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034943
name: trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi." [UM-BBD_reactionID:r0989]
xref: EC:6.2.1.-
xref: UM-BBD_enzymeID:e0617
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0034944
name: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA + NAD+ = 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + NADH+ + H+." [UM-BBD_reactionID:r0986]
xref: EC:1.1.-.-
xref: UM-BBD_enzymeID:e0618
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0034945
name: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoASH = 3-Isopropylbut-3-enoyl-CoA + propanoyl-CoA." [UM-BBD_reactionID:r0987]
xref: EC:2.3.1.-
xref: UM-BBD_enzymeID:e0619
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0034946
name: 3-isopropylbut-3-enoyl-CoA thioesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-isopropylbut-3-enoyl-CoA + H2O = 3-isopropylbut-3-enoic acid + CoASH." [UM-BBD_reactionID:r0994]
xref: EC:3.1.2.-
xref: UM-BBD_enzymeID:e0620
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0034947
name: terephthalate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: terephthalate + H2O = benzoate + HCO3-." [UM-BBD_reactionID:r0321]
xref: EC:4.1.1.-
xref: UM-BBD_enzymeID:e0621
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034948
name: 2,6-dihydroxypseudooxynicotine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-methylaminobutyrate." [UM-BBD_reactionID:r0482]
xref: EC:3.7.1.-
xref: UM-BBD_enzymeID:e0625
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0034949
name: 1,1-dichloroethane reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,1-dichloroethane + 2 H+ + 2 e- = chloroethane + HCl." [UM-BBD_reactionID:r1008]
xref: EC:1.97.1.-
xref: UM-BBD_enzymeID:e0627
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0034950
name: phenylboronic acid monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylboronic acid + O2 + 2 H+ + 2 e- = phenol + B(OH)3." [UM-BBD_reactionID:r1020]
xref: EC:1.14.-.-
xref: UM-BBD_enzymeID:e0630
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0034951
name: o-hydroxylaminobenzoate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: o-hydroxylaminobenzoate = 3-hydroxyanthranilate." [UM-BBD_reactionID:r1026]
xref: EC:5.4.99.-
xref: MetaCyc:RXN-8846
xref: UM-BBD_enzymeID:e0632
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0034952
name: malonate semialdehyde decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonate semialdehyde + H+ = acetaldehyde + CO2." [UM-BBD_reactionID:r0266]
xref: EC:4.1.1.-
xref: UM-BBD_enzymeID:e0634
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0034953
name: perillyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: perillyl-CoA + H2O = 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r1002]
xref: EC:4.2.1.-
xref: UM-BBD_enzymeID:e0635
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0034954
name: diphenyl ether 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphenyl ether + O2 = 2,3-dihydroxydiphenyl ether." [UM-BBD_reactionID:r1450]
xref: EC:1.14.12.-
xref: UM-BBD_enzymeID:e0922
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0034955
name: 2,3-dihydroxydiphenyl ether dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxydiphenyl ether + O2 + H2O = 2-hydroxymuconate + phenol." [UM-BBD_reactionID:r1451]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0923
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034956
name: diphenyl ether 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: diphenyl ether + NADH + O2 + H+ = phenol + catechol + NAD+." [UM-BBD_reactionID:r1453]
xref: EC:1.13.11.-
xref: UM-BBD_enzymeID:e0925
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0034957
name: 3-nitrophenol nitroreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-nitrophenol + 2 NADH + 2 H+ = 3-hydroxyaminophenol + 2 NAD+ + H2O." [UM-BBD_reactionID:r1495]
xref: EC:1.7.1.-
xref: UM-BBD_enzymeID:e0952
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0034958
name: aminohydroquinone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: aminohydroquinone + 2 e- + 2 H+ + 1/2 O2 = 1,2,4-benzenetriol + NH3." [UM-BBD_reactionID:r1497]
xref: EC:3.5.99.-
xref: UM-BBD_enzymeID:e0954
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0034959
name: endothelin maturation
namespace: biological_process
def: "The process leading to the attainment of the full functional capacity of endothelin by conversion of Big-endothelin substrate into mature endothelin." [GOC:BHF, GOC:rl]
is_a: GO:0016486 ! peptide hormone processing
relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood

[Term]
id: GO:0034963
name: box C/D snoRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript into a mature box C/D snoRNA." [GOC:mah]
is_a: GO:0033967 ! box C/D snoRNA metabolic process
is_a: GO:0043144 ! snoRNA processing

[Term]
id: GO:0034964
name: box H/ACA snoRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript into a mature box H/ACA snoRNA." [GOC:mah]
is_a: GO:0033979 ! box H/ACA snoRNA metabolic process
is_a: GO:0043144 ! snoRNA processing

[Term]
id: GO:0034965
name: intronic box C/D snoRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box C/D snoRNA." [GOC:mah]
is_a: GO:0031070 ! intronic snoRNA processing
is_a: GO:0034963 ! box C/D snoRNA processing

[Term]
id: GO:0034966
name: intronic box H/ACA snoRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box H/ACA snoRNA." [GOC:mah]
is_a: GO:0031070 ! intronic snoRNA processing
is_a: GO:0034964 ! box H/ACA snoRNA processing

[Term]
id: GO:0034967
name: Set3 complex
namespace: cellular_component
def: "A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p." [GOC:ds, PMID:11711434]
synonym: "HDAC3 complex" EXACT []
synonym: "SET3C" EXACT []
is_a: GO:0000118 ! histone deacetylase complex
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0034968
name: histone lysine methylation
namespace: biological_process
def: "The modification of a histone by addition of a methyl group to a lysine residue." [GOC:mah]
is_a: GO:0016571 ! histone methylation

[Term]
id: GO:0034969
name: histone arginine methylation
namespace: biological_process
def: "The modification of a histone by addition of a methyl group to an arginine residue." [GOC:mah]
is_a: GO:0016571 ! histone methylation

[Term]
id: GO:0034970
name: histone H3-R2 methylation
namespace: biological_process
def: "The modification of histone H3 by addition of a methyl group to arginine at position 2 of the histone." [GOC:mah]
synonym: "histone H3 R2 methylation" EXACT []
synonym: "histone H3R2me" EXACT []
synonym: "histone lysine H3 R2 methylation" EXACT []
is_a: GO:0034969 ! histone arginine methylation

[Term]
id: GO:0034971
name: histone H3-R17 methylation
namespace: biological_process
def: "The modification of histone H3 by addition of a methyl group to arginine at position 17 of the histone." [GOC:mah]
synonym: "histone H3 R17 methylation" EXACT []
synonym: "histone H3R17me" EXACT []
synonym: "histone lysine H3 R17 methylation" EXACT []
is_a: GO:0034969 ! histone arginine methylation

[Term]
id: GO:0034972
name: histone H3-R26 methylation
namespace: biological_process
def: "The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah]
synonym: "histone H3 R26 methylation" EXACT []
synonym: "histone H3R26me" EXACT []
synonym: "histone lysine H3 R26 methylation" EXACT []
is_a: GO:0034969 ! histone arginine methylation

[Term]
id: GO:0034973
name: Sid2-Mob1 complex
namespace: cellular_component
def: "A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex." [GOC:vw, PMID:10837231, PMID:15060149]
synonym: "Dbf2p-Mob1p complex" EXACT []
synonym: "Sid2-Mob1 kinase complex" EXACT []
synonym: "Sid2p-Mob1p complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034974
name: Swi5-Swi2 complex
namespace: cellular_component
def: "A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching." [PMID:14663140]
comment: Note that this term refers to Schizosaccharomyces pombe Swi5 and Swi2, which should not be confused with the unrelated Saccharomyces Swi5p and Swi2p.
synonym: "Swi5 complex" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0034975
name: protein folding in endoplasmic reticulum
namespace: biological_process
def: "A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw]
synonym: "protein folding in ER" EXACT []
is_a: GO:0006457 ! protein folding

[Term]
id: GO:0034976
name: response to endoplasmic reticulum stress
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah]
synonym: "ER stress response" EXACT []
synonym: "response to ER stress" EXACT []
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0034977
name: ABIN2-NFKB1-MAP3K8 complex
namespace: cellular_component
def: "A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages." [PMID:15169888]
synonym: "ABIN2-NFKB1-TPL-1 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0034978
name: PDX1-PBX1b-MRG1 complex
namespace: cellular_component
def: "A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes." [PMID:11279116, PMID:9710595]
synonym: "acinar cell-specific C complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0034979
name: NAD-dependent protein deacetylase activity
namespace: molecular_function
def: "Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD." [GOC:BHF, GOC:mah]
is_a: GO:0033558 ! protein deacetylase activity

[Term]
id: GO:0034980
name: FHL2-CREB complex
namespace: cellular_component
def: "A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation." [PMID:11046156]
is_a: GO:0033202 ! DNA helicase complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0034981
name: FHL3-CREB complex
namespace: cellular_component
def: "A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation." [PMID:11046156]
is_a: GO:0033202 ! DNA helicase complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0034982
name: mitochondrial protein processing
namespace: biological_process
def: "The peptide cleavage of proteins in the mitochondrion, including cleavage during import." [GOC:curators]
synonym: "mitochondrial protein modification" RELATED []
is_a: GO:0016485 ! protein processing

[Term]
id: GO:0034983
name: peptidyl-lysine deacetylation
namespace: biological_process
def: "The removal of an acetyl group from an acetylated lysine residue in a peptide or protein." [GOC:BHF, GOC:mah]
synonym: "protein lysine acetylation" RELATED []
is_a: GO:0006476 ! protein amino acid deacetylation
is_a: GO:0018205 ! peptidyl-lysine modification

[Term]
id: GO:0034985
name: Ecsit-NDUFAF1 complex
namespace: cellular_component
def: "Any large protein complex that contains Ecsit and NDUFAF1, is located in the mitochondrion, and is involved in the assembly of complex I of the oxidative phosphorylation system. In mammalian cells, three complexes of approximately 500, 600, and 850 kDa containing the 45 kDa isoform of Ecsit and NDUFAF1 have been observed." [PMID:17344420]
is_a: GO:0043234 ! protein complex
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0034986
name: iron chaperone activity
namespace: molecular_function
def: "Assists in the delivery of iron ions to target proteins or compartments." [GOC:vk]
is_a: GO:0005506 ! iron ion binding
is_a: GO:0016530 ! metallochaperone activity

[Term]
id: GO:0034987
name: immunoglobulin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule." [GOC:BHF, GOC:vk]
synonym: "Fc receptor binding" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0034988
name: Fc-gamma receptor I complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG." [GOC:BHF, GOC:vk]
is_a: GO:0034987 ! immunoglobulin receptor binding

[Term]
id: GO:0034989
name: GTP-Ral binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the GTP-bound form of the Ral protein." [GOC:vk]
is_a: GO:0017160 ! Ral GTPase binding

[Term]
id: GO:0034990
name: nuclear mitotic cohesin complex
namespace: cellular_component
def: "A cohesin complex that mediates sister chromatid cohesion in the nucleus during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah]
comment: Note that this term should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i. e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used.
is_a: GO:0000798 ! nuclear cohesin complex
is_a: GO:0030892 ! mitotic cohesin complex

[Term]
id: GO:0034991
name: nuclear meiotic cohesin complex
namespace: cellular_component
def: "A cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah]
comment: Note that this term should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i. e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used.
is_a: GO:0000798 ! nuclear cohesin complex
is_a: GO:0030893 ! meiotic cohesin complex

[Term]
id: GO:0034992
name: microtubule organizing center attachment site
namespace: cellular_component
def: "A region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches; protein complexes embedded in the nuclear envelope mediate direct or indirect linkages between the microtubule cytoskeleton and the nuclear envelope." [GOC:mah, PMID:18692466]
comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'.
synonym: "MAS" EXACT []
synonym: "microtubule organising centre attachment site" EXACT []
synonym: "MTOC attachment site" EXACT []
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0034993
name: SUN-KASH complex
namespace: cellular_component
def: "A protein complex that spans the nuclear outer and inner membranes, thereby linking the major cytoplasmic cytoskeleton elements to the nuclear lumen; the complex is conserved in eukaryotes and contains proteins with SUN and KASH domains." [GOC:mah, PMID:18692466]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0034992 ! microtubule organizing center attachment site

[Term]
id: GO:0034994
name: microtubule organizing center attachment site organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center attachment site. A microtubule organizing center attachment site is a region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches." [GOC:mah, PMID:18692466]
synonym: "MAS organization" EXACT []
synonym: "microtubule organising centre attachment site organisation" RELATED []
synonym: "MTOC attachment site organization" EXACT []
is_a: GO:0009987 ! cellular process
is_a: GO:0016043 ! cellular component organization
relationship: part_of GO:0006998 ! nuclear envelope organization

[Term]
id: GO:0034995
name: SC5b-7 complex
namespace: cellular_component
def: "A protein complex that consist of complement components C5b6 and C7 stably inserted in a cell membrane. Formation of the SC5b-7 complex is the first phase of membrane attack complex assembly." [PMID:10090939]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0034996
name: RasGAP-Fyn-Lyn-Yes complex
namespace: cellular_component
def: "A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation." [PMID:1544885]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
synonym: "p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0034997
name: alphav-beta5 integrin-vitronectin complex
namespace: cellular_component
def: "A protein complex that comprises one integrin alphav subunit, one integrin beta5 subunit, and vitronectin." [PMID:1694173, Reactome:REACT_14045.1]
synonym: "ITGAV-ITGB5-VTN complex" NARROW [CORUM:3117]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0034998
name: oligosaccharyltransferase I complex
namespace: cellular_component
def: "An oligosaccharyltransferase (OST) complex that contains at least seven polypeptides and is the major OST complex in mammalian cells. Of the three forms of mammalian OST complex identified, the OSTI complex has the weakest affinity for ribosomes." [PMID:15835887]
synonym: "OSTCI" EXACT []
is_a: GO:0008250 ! oligosaccharyltransferase complex

[Term]
id: GO:0034999
name: oligosaccharyltransferase II complex
namespace: cellular_component
def: "An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma. Of the three forms of mammalian OST complexes identified, the OSTII complex has intermediate affinity for ribosomes." [GOC:BHF, PMID:15835887]
synonym: "OSTCII" EXACT []
is_a: GO:0008250 ! oligosaccharyltransferase complex

[Term]
id: GO:0035000
name: oligosaccharyltransferase III complex
namespace: cellular_component
def: "An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma and the tetrameric TRAP complex. Of the three forms of mammalian OST complexes identified, the OSTIII complex has the strongest affinity for ribosomes." [PMID:15835887]
synonym: "OSTCIII" EXACT []
is_a: GO:0008250 ! oligosaccharyltransferase complex

[Term]
id: GO:0035001
name: dorsal trunk growth, open tracheal system
namespace: biological_process
def: "Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system." [GOC:mtg_sensu, ISBN:0879694238]
synonym: "dorsal trunk growth" RELATED []
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035002
name: liquid clearance, open tracheal system
namespace: biological_process
def: "The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352]
synonym: "tracheal liquid clearance" EXACT []
is_a: GO:0042045 ! epithelial fluid transport
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035003
name: subapical complex
namespace: cellular_component
def: "The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938]
synonym: "SAC" BROAD []
is_a: GO:0005911 ! cell-cell junction
relationship: part_of GO:0043296 ! apical junction complex

[Term]
id: GO:0035004
name: phosphoinositide 3-kinase activity
namespace: molecular_function
def: "Catalysis of the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3]." [GOC:bf, PMID:10209156, PMID:9255069]
xref: EC:2.7.1.-
xref: MetaCyc:2.7.1.154-RXN
xref: Wikipedia:Phosphoinositide_3-kinase
is_a: GO:0001727 ! lipid kinase activity
is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0035005
name: phosphatidylinositol-4-phosphate 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate." [EC:2.7.1.154, GOC:bf]
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.154]
synonym: "C2-domain-containing phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.154]
synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW []
synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW []
synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW []
synonym: "type II phosphoinositide 3-kinase activity" RELATED [EC:2.7.1.154]
xref: EC:2.7.1.154
xref: MetaCyc:2.7.1.154-RXN
is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity
is_a: GO:0035004 ! phosphoinositide 3-kinase activity

[Term]
id: GO:0035006
name: melanization defense response
namespace: biological_process
def: "The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809]
synonym: "melanization defence response" EXACT []
is_a: GO:0006582 ! melanin metabolic process
is_a: GO:0045087 ! innate immune response

[Term]
id: GO:0035007
name: regulation of melanization defense response
namespace: biological_process
def: "Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf]
synonym: "regulation of melanization defence response" EXACT []
is_a: GO:0043455 ! regulation of secondary metabolic process
is_a: GO:0045088 ! regulation of innate immune response
relationship: regulates GO:0035006 ! melanization defense response

[Term]
id: GO:0035008
name: positive regulation of melanization defense response
namespace: biological_process
def: "Any process that increases the rate or extent of the melanization defense response during injury or invasion." [GOC:bf]
synonym: "activation of melanization defense response" NARROW []
synonym: "positive regulation of melanization defence response" EXACT []
synonym: "stimulation of melanization defense response" NARROW []
synonym: "up regulation of melanization defense response" EXACT []
synonym: "up-regulation of melanization defense response" EXACT []
synonym: "upregulation of melanization defense response" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0035007 ! regulation of melanization defense response
is_a: GO:0045089 ! positive regulation of innate immune response
relationship: positively_regulates GO:0035006 ! melanization defense response

[Term]
id: GO:0035009
name: negative regulation of melanization defense response
namespace: biological_process
def: "Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection." [GOC:bf, PMID:12408809]
synonym: "down regulation of melanization defense response" EXACT []
synonym: "down-regulation of melanization defense response" EXACT []
synonym: "downregulation of melanization defense response" EXACT []
synonym: "inhibition of melanization defense response" NARROW []
synonym: "negative regulation of melanization defence response" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0035007 ! regulation of melanization defense response
is_a: GO:0045824 ! negative regulation of innate immune response
relationship: negatively_regulates GO:0035006 ! melanization defense response

[Term]
id: GO:0035010
name: encapsulation of foreign target
namespace: biological_process
def: "Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, GOC:mtg_15nov05, PMID:11846478, PMID:12225920]
comment: This term was improved by GO_REF:0000022. It was moved.
is_a: GO:0002252 ! immune effector process

[Term]
id: GO:0035011
name: melanotic encapsulation of foreign target
namespace: biological_process
def: "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf]
is_a: GO:0035006 ! melanization defense response
is_a: GO:0035010 ! encapsulation of foreign target

[Term]
id: GO:0035012
name: polytene chromosome, telomeric region
namespace: cellular_component
def: "The terminal region of a polytene chromosome." [GOC:bf]
is_a: GO:0000781 ! chromosome, telomeric region
relationship: part_of GO:0005700 ! polytene chromosome

[Term]
id: GO:0035013
name: myosuppressin receptor activity
namespace: molecular_function
def: "Combining with the peptide myosuppressin to initiate a change in cell activity." [GOC:bf]
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0035014
name: phosphoinositide 3-kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates." [GOC:bf, PMID:9255069]
comment: See also the molecular function term 'phosphoinositide 3-kinase activity ; GO:0035004'.
synonym: "PI3K regulator activity" EXACT []
is_a: GO:0019207 ! kinase regulator activity

[Term]
id: GO:0035015
name: elongation of arista core
namespace: biological_process
def: "The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0048800 ! antennal morphogenesis

[Term]
id: GO:0035016
name: elongation of arista lateral
namespace: biological_process
def: "The increase in length of the aristal laterals. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0048800 ! antennal morphogenesis

[Term]
id: GO:0035017
name: cuticle pattern formation
namespace: biological_process
def: "The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0042335 ! cuticle development

[Term]
id: GO:0035018
name: adult chitin-based cuticle pattern formation
namespace: biological_process
def: "The process that gives rise to the patterns of cell differentiation that will arise in the chitin-based adult cuticle. An example of this process is adult chitin-based cuticle pattern formation in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "adult cuticle pattern formation" BROAD []
is_a: GO:0035017 ! cuticle pattern formation
relationship: part_of GO:0008365 ! adult chitin-based cuticle development

[Term]
id: GO:0035019
name: somatic stem cell maintenance
namespace: biological_process
def: "The process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089]
is_a: GO:0019827 ! stem cell maintenance

[Term]
id: GO:0035020
name: regulation of Rac protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Rac protein signal transduction." [GOC:bf]
is_a: GO:0046578 ! regulation of Ras protein signal transduction
relationship: regulates GO:0016601 ! Rac protein signal transduction

[Term]
id: GO:0035021
name: negative regulation of Rac protein signal transduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Rac protein signal transduction." [GOC:bf]
synonym: "down regulation of Rac protein signal transduction" EXACT []
synonym: "down-regulation of Rac protein signal transduction" EXACT []
synonym: "downregulation of Rac protein signal transduction" EXACT []
synonym: "inhibition of Rac protein signal transduction" NARROW []
is_a: GO:0035020 ! regulation of Rac protein signal transduction
is_a: GO:0046580 ! negative regulation of Ras protein signal transduction
relationship: negatively_regulates GO:0016601 ! Rac protein signal transduction

[Term]
id: GO:0035022
name: positive regulation of Rac protein signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction." [GOC:bf]
synonym: "activation of Rac protein signal transduction" NARROW []
synonym: "stimulation of Rac protein signal transduction" NARROW []
synonym: "up regulation of Rac protein signal transduction" EXACT []
synonym: "up-regulation of Rac protein signal transduction" EXACT []
synonym: "upregulation of Rac protein signal transduction" EXACT []
is_a: GO:0035020 ! regulation of Rac protein signal transduction
is_a: GO:0046579 ! positive regulation of Ras protein signal transduction
relationship: positively_regulates GO:0016601 ! Rac protein signal transduction

[Term]
id: GO:0035023
name: regulation of Rho protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]
is_a: GO:0046578 ! regulation of Ras protein signal transduction
relationship: regulates GO:0007266 ! Rho protein signal transduction

[Term]
id: GO:0035024
name: negative regulation of Rho protein signal transduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]
synonym: "down regulation of Rho protein signal transduction" EXACT []
synonym: "down-regulation of Rho protein signal transduction" EXACT []
synonym: "downregulation of Rho protein signal transduction" EXACT []
synonym: "inhibition of Rho protein signal transduction" NARROW []
is_a: GO:0035023 ! regulation of Rho protein signal transduction
is_a: GO:0046580 ! negative regulation of Ras protein signal transduction
relationship: negatively_regulates GO:0007266 ! Rho protein signal transduction

[Term]
id: GO:0035025
name: positive regulation of Rho protein signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf]
synonym: "activation of Rho protein signal transduction" NARROW []
synonym: "stimulation of Rho protein signal transduction" NARROW []
synonym: "up regulation of Rho protein signal transduction" EXACT []
synonym: "up-regulation of Rho protein signal transduction" EXACT []
synonym: "upregulation of Rho protein signal transduction" EXACT []
is_a: GO:0035023 ! regulation of Rho protein signal transduction
is_a: GO:0046579 ! positive regulation of Ras protein signal transduction
relationship: positively_regulates GO:0007266 ! Rho protein signal transduction

[Term]
id: GO:0035026
name: leading edge cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet." [GOC:bf]
is_a: GO:0030855 ! epithelial cell differentiation

[Term]
id: GO:0035027
name: leading edge cell fate commitment
namespace: biological_process
def: "The commitment of cells to leading edge cell fate and their capacity to differentiate into leading edge cells. Leading edge cells are found at the front of a migrating epithelial sheet." [GOC:bf]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0035026 ! leading edge cell differentiation

[Term]
id: GO:0035028
name: leading edge cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0035027 ! leading edge cell fate commitment

[Term]
id: GO:0035029
name: dorsal closure, leading edge cell fate commitment
namespace: biological_process
def: "The commitment of cells to leading edge cell fate during dorsal closure. Leading edge cells are the dorsal-most cells of the migrating epidermis." [GOC:bf]
is_a: GO:0035027 ! leading edge cell fate commitment
relationship: part_of GO:0046663 ! dorsal closure, leading edge cell differentiation

[Term]
id: GO:0035032
name: phosphoinositide 3-kinase complex, class III
namespace: cellular_component
def: "A complex containing a heterodimer of a catalytic Class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI)." [GOC:bf, PMID:9255069]
synonym: "class III PI3K complex" EXACT []
is_a: GO:0005942 ! phosphoinositide 3-kinase complex

[Term]
id: GO:0035033
name: histone deacetylase regulator activity
namespace: molecular_function
def: "Modulates the activity of histone deacetylase." [GOC:bf]
comment: See also the molecular function term 'histone deacetylase activity ; GO:0004407'.
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0035034
name: histone acetyltransferase regulator activity
namespace: molecular_function
def: "Modulates the activity of histone acetyltransferase." [GOC:bf]
comment: See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'.
synonym: "histone acetylase regulator activity" EXACT []
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0035035
name: histone acetyltransferase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme histone acetyltransferase." [GOC:bf]
synonym: "histone acetylase binding" EXACT []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0035036
name: sperm-egg recognition
namespace: biological_process
def: "The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization." [GOC:bf]
is_a: GO:0009988 ! cell-cell recognition
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035037
name: sperm entry
namespace: biological_process
def: "Penetration of the egg shell through the micropyle (a specialized anterior opening in the vitelline envelope) and entry of the entire sperm, including the surrounding plasma membrane and the sperm tail, into the egg cytoplasm. This step in fertilization is seen in Drosophila, where a plasma membrane fusion event between the sperm and the egg does not occur." [GOC:bf, PMID:9630751]
is_a: GO:0006897 ! endocytosis
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035038
name: female pronucleus assembly
namespace: biological_process
def: "Assembly of the haploid nucleus of the unfertilized egg." [GOC:bf, ISBN:0582227089]
synonym: "female pronucleus assembly" RELATED [GOC:dph]
is_a: GO:0006997 ! nucleus organization
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035039
name: male pronucleus assembly
namespace: biological_process
def: "The conversion at fertilization of the inactive sperm nucleus into a male pronucleus with its chromosomes processed for the first zygotic division." [GOC:bf, PMID:11735001]
synonym: "male pronucleus formation" RELATED [GOC:dph]
is_a: GO:0006997 ! nucleus organization
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035040
name: sperm nuclear envelope removal
namespace: biological_process
def: "Removal of the sperm nuclear envelope, allowing entry of maternal factors into the sperm nucleus." [GOC:bf, PMID:11735001]
is_a: GO:0051081 ! nuclear envelope disassembly
relationship: part_of GO:0035039 ! male pronucleus assembly

[Term]
id: GO:0035041
name: sperm chromatin decondensation
namespace: biological_process
def: "Unwinding of the condensed nuclear chromatin of an inactive sperm nucleus." [GOC:bf, PMID:11735001]
is_a: GO:0006325 ! chromatin organization
relationship: part_of GO:0035039 ! male pronucleus assembly

[Term]
id: GO:0035042
name: fertilization, exchange of chromosomal proteins
namespace: biological_process
def: "Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity." [GOC:bf, PMID:11735001]
synonym: "sperm-specific histone exchange" EXACT []
synonym: "sperm-specific histone replacement" EXACT []
is_a: GO:0043486 ! histone exchange
relationship: part_of GO:0035041 ! sperm chromatin decondensation

[Term]
id: GO:0035043
name: male pronuclear envelope synthesis
namespace: biological_process
def: "Assembly of a nuclear envelope containing nuclear pores and a lamina around the male pronucleus, the final step in sperm pronuclear formation." [GOC:bf, PMID:11735001]
is_a: GO:0018985 ! pronuclear envelope synthesis
relationship: part_of GO:0035039 ! male pronucleus assembly

[Term]
id: GO:0035044
name: sperm aster formation
namespace: biological_process
def: "Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei." [GOC:bf, ISBN:0879694238]
is_a: GO:0000226 ! microtubule cytoskeleton organization
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035045
name: sperm plasma membrane disassembly
namespace: biological_process
def: "The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg." [GOC:bf, ISBN:0879694238]
synonym: "sperm plasma membrane breakdown" EXACT []
synonym: "sperm plasma membrane catabolism" EXACT []
synonym: "sperm plasma membrane degradation" EXACT []
is_a: GO:0030397 ! membrane disassembly
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035046
name: pronuclear migration
namespace: biological_process
def: "The directed movement of the male and female pronuclei towards each other prior to their fusion." [GOC:bf, PMID:9199363]
is_a: GO:0007097 ! nuclear migration
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035047
name: centrosomal and pronuclear rotation
namespace: biological_process
def: "The rotation of centrosomes and associated pronuclei in one-cell embryos such as those of Caenorhabditis elegans, occurring as a transition between pronuclear migration and pronuclear fusion." [GOC:bf, ISBN:087969307X, PMID:10085292]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048610 ! reproductive cellular process
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0035048
name: splicing factor protein import into nucleus
namespace: biological_process
def: "The directed movement of a pre-mRNA splicing factor from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:bf]
synonym: "splicing factor protein transport from cytoplasm to nucleus" EXACT []
synonym: "splicing factor protein-nucleus import" EXACT []
is_a: GO:0006606 ! protein import into nucleus

[Term]
id: GO:0035049
name: juvenile hormone acid methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to juvenile hormone acid." [GOC:bf]
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0035050
name: embryonic heart tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0007507 ! heart development
relationship: part_of GO:0009790 ! embryonic development

[Term]
id: GO:0035051
name: cardiac cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf]
synonym: "heart cell differentiation" RELATED []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0035052
name: dorsal vessel aortic cell fate commitment
namespace: biological_process
def: "The commitment of dorsal vessel cardioblast cells to an aortic cell fate and their capacity to differentiate into aortic cells. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12397110]
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0035054 ! embryonic heart tube anterior/posterior pattern formation

[Term]
id: GO:0035053
name: dorsal vessel heart proper cell fate commitment
namespace: biological_process
def: "The commitment of dorsal vessel cardioblast cells to a heart proper cell fate and their capacity to differentiate into heart cells. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12397110]
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0035054 ! embryonic heart tube anterior/posterior pattern formation

[Term]
id: GO:0035054
name: embryonic heart tube anterior/posterior pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of cell differentiation that results in the anterior/posterior subdivision of the embryonic heart tube. In Drosophila this results in subdivision of the dorsal vessel into to the posterior heart proper and the anterior aorta." [GOC:bf, PMID:12435360]
is_a: GO:0009952 ! anterior/posterior pattern formation
relationship: part_of GO:0035050 ! embryonic heart tube development

[Term]
id: GO:0035058
name: sensory cilium assembly
namespace: biological_process
def: "The assembly of a sensory cilium, a primary cilium found on sensory neurons that contains an a 9+0 axonemal arrangement of microtubules." [GOC:bf, PMID:14521833, PMID:14521834]
synonym: "sensory cilium biogenesis" RELATED [GOC:mah]
is_a: GO:0042384 ! cilium assembly

[Term]
id: GO:0035059
name: RCAF complex
namespace: cellular_component
def: "A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4." [GOC:bf, PMID:10591219]
synonym: "replication-coupling assembly factor complex" EXACT []
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0035060
name: brahma complex
namespace: cellular_component
def: "A SWI/SNF-type complex that contains the ATPase product of the Drosophila brahma gene, or an ortholog thereof." [GOC:bf, PMID:10809665, PMID:12482982]
synonym: "BRM complex" EXACT []
is_a: GO:0070603 ! SWI/SNF-type complex

[Term]
id: GO:0035061
name: interchromatin granule
namespace: cellular_component
def: "A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439]
synonym: "ICG" EXACT []
xref: NIF_Subcellular:sao1049471211
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0035062
name: omega speckle
namespace: cellular_component
def: "A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439]
is_a: GO:0016607 ! nuclear speck

[Term]
id: GO:0035063
name: nuclear speck organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized." [GOC:bf, GOC:curators]
comment: See also the cellular component term 'nuclear speck ; GO:0016607'.
synonym: "nuclear speck organisation" EXACT [GOC:curators]
synonym: "nuclear speck organization and biogenesis" RELATED [GOC:mah]
synonym: "nuclear speckle assembly" NARROW [GOC:mah]
synonym: "nuclear speckle organization" EXACT []
is_a: GO:0030575 ! nuclear body organization

[Term]
id: GO:0035064
name: methylated histone residue binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a methylated residue on a histone protein. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf, PMID:14585615]
is_a: GO:0042393 ! histone binding

[Term]
id: GO:0035065
name: regulation of histone acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf]
is_a: GO:0031056 ! regulation of histone modification
relationship: regulates GO:0016573 ! histone acetylation

[Term]
id: GO:0035066
name: positive regulation of histone acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf]
synonym: "activation of histone acetylation" NARROW []
synonym: "stimulation of histone acetylation" NARROW []
synonym: "up regulation of histone acetylation" EXACT []
synonym: "up-regulation of histone acetylation" EXACT []
synonym: "upregulation of histone acetylation" EXACT []
is_a: GO:0031058 ! positive regulation of histone modification
is_a: GO:0035065 ! regulation of histone acetylation
relationship: positively_regulates GO:0016573 ! histone acetylation

[Term]
id: GO:0035067
name: negative regulation of histone acetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf]
synonym: "down regulation of histone acetylation" EXACT []
synonym: "down-regulation of histone acetylation" EXACT []
synonym: "downregulation of histone acetylation" EXACT []
synonym: "inhibition of histone acetylation" NARROW []
is_a: GO:0031057 ! negative regulation of histone modification
is_a: GO:0035065 ! regulation of histone acetylation
relationship: negatively_regulates GO:0016573 ! histone acetylation

[Term]
id: GO:0035068
name: micro-ribonucleoprotein complex
namespace: cellular_component
def: "A complex containing both protein and micro-RNA (miRNA) molecules. miRNAs are approximately 22 nucleotide noncoding RNAs derived from endogenous genes; they are processed from the stem of a longer hairpin like structure termed a pre-miRNA." [GOC:bf, PMID:14559182]
synonym: "miRNP complex" EXACT []
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0035069
name: larval midgut histolysis
namespace: biological_process
def: "The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683]
is_a: GO:0007559 ! histolysis
relationship: part_of GO:0007552 ! metamorphosis
relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis

[Term]
id: GO:0035070
name: salivary gland histolysis
namespace: biological_process
def: "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, PMID:9409683]
is_a: GO:0007435 ! salivary gland morphogenesis
is_a: GO:0007559 ! histolysis
relationship: part_of GO:0007552 ! metamorphosis
relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis

[Term]
id: GO:0035071
name: salivary gland cell autophagic cell death
namespace: biological_process
def: "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, PMID:10882130]
synonym: "autophagic cell death of salivary gland cells" EXACT []
synonym: "programmed cell death of salivary gland cells by autophagy" EXACT []
synonym: "salivary gland cell death" EXACT []
synonym: "salivary gland cell programmed cell death by autophagy" EXACT []
is_a: GO:0048102 ! autophagic cell death
relationship: part_of GO:0035070 ! salivary gland histolysis

[Term]
id: GO:0035072
name: ecdysone-mediated induction of salivary gland cell autophagic cell death
namespace: biological_process
def: "Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis." [GOC:bf]
synonym: "ecdysone-mediated induction of autophagic cell death of salivary gland cells" EXACT []
synonym: "ecdysone-mediated induction of programmed cell death of salivary gland cells by autophagy" EXACT []
synonym: "ecdysone-mediated induction of salivary gland cell programmed cell death by autophagy" EXACT []
is_a: GO:0035078 ! induction of programmed cell death by ecdysone
relationship: part_of GO:0035071 ! salivary gland cell autophagic cell death

[Term]
id: GO:0035073
name: pupariation
namespace: biological_process
def: "The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683]
synonym: "puparium biosynthesis" EXACT []
synonym: "puparium formation" EXACT []
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0035210 ! prepupal development

[Term]
id: GO:0035074
name: pupation
namespace: biological_process
def: "The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period." [GOC:bf, ISBN:0582227089, ISBN:0879694238]
synonym: "head eversion" EXACT []
synonym: "prepupal-pupal transition" EXACT []
xref: Wikipedia:Pupa
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0035209 ! pupal development

[Term]
id: GO:0035075
name: response to ecdysone
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf]
is_a: GO:0048545 ! response to steroid hormone stimulus
relationship: part_of GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0035076
name: ecdysone receptor-mediated signaling pathway
namespace: biological_process
def: "The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex." [GOC:bf]
synonym: "ecdysone receptor-mediated signalling pathway" EXACT []
is_a: GO:0030518 ! steroid hormone receptor signaling pathway
is_a: GO:0071390 ! cellular response to ecdysone

[Term]
id: GO:0035077
name: ecdysone-mediated polytene chromosome puffing
namespace: biological_process
def: "The decondensing (loosening) and swelling of the chromosomal sites of hormone-responsive genes on polytene chromosomes in response to increased production of the steroid hormone 20-hydroxyecdysone (ecdysone) in Drosophila larvae approaching pupation." [GOC:bf, PMID:12543962]
is_a: GO:0035079 ! polytene chromosome puffing
is_a: GO:0071390 ! cellular response to ecdysone

[Term]
id: GO:0035078
name: induction of programmed cell death by ecdysone
namespace: biological_process
def: "Any process induced by the steroid hormone 20-hydroxyecdysone (ecdysone) that directly activates any of the steps required for programmed cell death." [GOC:bf]
is_a: GO:0035075 ! response to ecdysone
is_a: GO:0035081 ! induction of programmed cell death by hormones

[Term]
id: GO:0035079
name: polytene chromosome puffing
namespace: biological_process
def: "The decondensing (loosening) and swelling of the chromosomal sites of target genes on polytene chromosomes following response to a stimulus, to facilitate sudden bursts of transcriptional activity in response to transient environmental signals." [GOC:bf, PMID:12543962]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0035080
name: heat shock-mediated polytene chromosome puffing
namespace: biological_process
def: "The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus." [GOC:bf, PMID:12543962]
is_a: GO:0034605 ! cellular response to heat
is_a: GO:0035079 ! polytene chromosome puffing

[Term]
id: GO:0035081
name: induction of programmed cell death by hormones
namespace: biological_process
def: "Any process induced by hormones that directly activates any of the steps required for programmed cell death." [GOC:bf]
is_a: GO:0012502 ! induction of programmed cell death

[Term]
id: GO:0035082
name: axoneme assembly
namespace: biological_process
def: "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0815316194]
synonym: "axoneme biogenesis" RELATED [GOC:mah]
is_a: GO:0001578 ! microtubule bundle formation
is_a: GO:0030031 ! cell projection assembly

[Term]
id: GO:0035083
name: cilium axoneme assembly
namespace: biological_process
def: "The assembly of a the bundle of microtubules and associated proteins that forms the core of cilia in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0815316194]
synonym: "cilium axoneme biogenesis" RELATED [GOC:mah]
is_a: GO:0035082 ! axoneme assembly
relationship: part_of GO:0042384 ! cilium assembly

[Term]
id: GO:0035084
name: flagellar axoneme assembly
namespace: biological_process
def: "The assembly of the bundle of microtubules and associated proteins that forms the core of flagellar in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0815316194]
synonym: "flagella axoneme assembly" EXACT [GOC:mah]
synonym: "flagella axoneme biogenesis" RELATED []
synonym: "flagellar axoneme biogenesis" RELATED []
synonym: "flagellum axoneme assembly" EXACT [GOC:mah]
synonym: "flagellum axoneme biogenesis" RELATED []
is_a: GO:0035082 ! axoneme assembly
relationship: part_of GO:0009296 ! flagellum assembly

[Term]
id: GO:0035085
name: cilium axoneme
namespace: cellular_component
def: "The bundle of microtubules and associated proteins that forms the core of cilia in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0198547684]
is_a: GO:0005930 ! axoneme
is_a: GO:0044441 ! cilium part

[Term]
id: GO:0035086
name: flagellar axoneme
namespace: cellular_component
def: "The bundle of microtubules and associated proteins that forms the core of flagellar in eukaryotic cells and is responsible for their movements." [GOC:bf, ISBN:0198547684]
synonym: "flagellum axoneme" EXACT []
is_a: GO:0005930 ! axoneme
is_a: GO:0044442 ! microtubule-based flagellum part

[Term]
id: GO:0035087
name: siRNA loading onto RISC involved in RNA interference
namespace: biological_process
def: "The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference." [GOC:bf, GOC:mah, PMID:14512631]
synonym: "RNA interference, siRNA loading onto RISC" EXACT [GOC:mah]
is_a: GO:0070922 ! small RNA loading onto RISC
relationship: part_of GO:0016246 ! RNA interference

[Term]
id: GO:0035088
name: establishment or maintenance of apical/basal cell polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483]
is_a: GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0035089
name: establishment of apical/basal cell polarity
namespace: biological_process
def: "The specification and formation of the polarity of a cell along its apical/basal axis." [GOC:bf]
is_a: GO:0030010 ! establishment of cell polarity
is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity

[Term]
id: GO:0035090
name: maintenance of apical/basal cell polarity
namespace: biological_process
def: "Retaining the established polarization of a cell along its apical/basal axis." [GOC:bf]
is_a: GO:0030011 ! maintenance of cell polarity
is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity

[Term]
id: GO:0035091
name: phosphoinositide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any inositol-containing glycerophospholipid." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0005543 ! phospholipid binding

[Term]
id: GO:0035092
name: sperm chromatin condensation
namespace: biological_process
def: "The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication." [GOC:bf, PMID:11735001]
is_a: GO:0006323 ! DNA packaging
is_a: GO:0006325 ! chromatin organization
relationship: part_of GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0035093
name: spermatogenesis, exchange of chromosomal proteins
namespace: biological_process
def: "The replacement of somatic histones within sperm chromatin with sperm-specific histones or protamines with unique DNA-binding properties, resulting in condensation of the sperm chromatin." [GOC:bf, PMID:11735001]
synonym: "somatic histone exchange" EXACT []
synonym: "somatic histone replacement" RELATED []
is_a: GO:0043486 ! histone exchange
relationship: part_of GO:0035092 ! sperm chromatin condensation

[Term]
id: GO:0035094
name: response to nicotine
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [ChEBI:17688, GOC:bf, GOC:ef, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0582227089]
is_a: GO:0014070 ! response to organic cyclic substance
is_a: GO:0043279 ! response to alkaloid

[Term]
id: GO:0035095
name: behavioral response to nicotine
namespace: biological_process
def: "A change in the behavior of an organism as a result of a nicotine stimulus." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "behavioural response to nicotine" EXACT []
is_a: GO:0030534 ! adult behavior
is_a: GO:0035094 ! response to nicotine

[Term]
id: GO:0035096
name: larval midgut cell programmed cell death
namespace: biological_process
def: "The stage-specific programmed cell death of cells of the larval midgut, during histolysis of the larval organ." [GOC:bf]
synonym: "larval midgut cell death" EXACT []
synonym: "programmed cell death of larval midgut cells" EXACT []
is_a: GO:0010623 ! developmental programmed cell death
relationship: part_of GO:0035069 ! larval midgut histolysis

[Term]
id: GO:0035097
name: histone methyltransferase complex
namespace: cellular_component
def: "A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins." [GOC:bf]
subset: goslim_pir
is_a: GO:0034708 ! methyltransferase complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0035098
name: ESC/E(Z) complex
namespace: cellular_component
def: "A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375]
synonym: "Extra Sex Combs/Enhancer of Zeste complex" EXACT []
synonym: "PRC2 complex" EXACT [GOC:sp, PMID:20064375]
is_a: GO:0031519 ! PcG protein complex
is_a: GO:0035097 ! histone methyltransferase complex

[Term]
id: GO:0035099
name: hemocyte migration
namespace: biological_process
def: "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551]
synonym: "arthropod blood cell migration" EXACT []
synonym: "hemocyte cell migration" EXACT []
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0035162 ! embryonic hemopoiesis

[Term]
id: GO:0035100
name: ecdysone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0582227089]
is_a: GO:0005496 ! steroid binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0035101
name: FACT complex
namespace: cellular_component
def: "An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer." [GOC:bf, GOC:expert_ks, GOC:expert_ras, GOC:expert_tf, GOC:krc, PMID:12934006, PMID:12934007, PMID:16678108]
synonym: "Facilitates chromatin transcription complex" EXACT []
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0035102
name: PRC1 complex
namespace: cellular_component
def: "An insect multiprotein complex containing the products of many of the Polycomb Group genes including Polycomb, Posterior sex combs, polyhomeotic and Sex comb on midleg. The Polycomb Group proteins are required for stable long-term maintenance of transcriptionally repressed states and the PRC1 complex directly antagonizes ATP-dependent remodeling of nucleosomal arrays." [GOC:bf, PMID:10412979]
synonym: "Polycomb repressive complex 1" EXACT []
is_a: GO:0031519 ! PcG protein complex

[Term]
id: GO:0035103
name: sterol regulatory element binding protein cleavage
namespace: biological_process
def: "The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to altered levels of one or more lipids." [GOC:bf, PMID:12923525]
synonym: "SREBP cleavage" EXACT []
is_a: GO:0051605 ! protein maturation by peptide bond cleavage
relationship: part_of GO:0032933 ! SREBP-mediated signaling pathway

[Term]
id: GO:0035104
name: positive regulation of transcription via sterol regulatory element binding
namespace: biological_process
def: "The process by which a sterol regulatory element binding protein (SREBP) mediates an increase in rate or extent of transcription of nuclear target genes in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs in the promoters of target genes." [GOC:bf, GOC:mah, PMID:12923525]
synonym: "activation of sterol regulatory element binding protein target gene transcription" NARROW []
synonym: "positive regulation of sterol regulatory element binding protein target gene transcription" EXACT [GOC:dph, GOC:tb]
synonym: "SREBP target gene transcriptional activation" EXACT []
synonym: "sterol regulatory element binding protein target gene transcriptional activation" BROAD []
synonym: "stimulation of sterol regulatory element binding protein target gene transcription" NARROW []
synonym: "up regulation of sterol regulatory element binding protein target gene transcription" EXACT []
synonym: "up-regulation of sterol regulatory element binding protein target gene transcription" EXACT []
synonym: "upregulation of sterol regulatory element binding protein target gene transcription" EXACT []
is_a: GO:0010552 ! positive regulation of gene-specific transcription from RNA polymerase II promoter
relationship: part_of GO:0032933 ! SREBP-mediated signaling pathway

[Term]
id: GO:0035105
name: sterol regulatory element binding protein nuclear translocation
namespace: biological_process
def: "The transfer of a sterol regulatory element binding protein (SREBP) into the nucleus, across the nuclear membrane, in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525]
synonym: "SREBP nuclear translocation" EXACT []
is_a: GO:0000060 ! protein import into nucleus, translocation
relationship: part_of GO:0032933 ! SREBP-mediated signaling pathway

[Term]
id: GO:0035106
name: operant conditioning
namespace: biological_process
def: "Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior." [PMID:14662373]
synonym: "instrumental conditioning" EXACT []
xref: Wikipedia:Operant_conditioning
is_a: GO:0007612 ! learning

[Term]
id: GO:0035107
name: appendage morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of appendages are generated and organized. Morphogenesis pertains to the creation of form. An appendage is an organ or part that is attached to the trunk of an organism. For example a limb or a branch." [ISBN:0582227089]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048736 ! appendage development

[Term]
id: GO:0035108
name: limb morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of limb are generated and organized. Morphogenesis pertains to the creation of form. A limb is an appendage of an animal used for locomotion or grasping. For example a leg, arm or some types of fin." [ISBN:0395825172]
synonym: "limb bud morphogenesis" NARROW [GOC:dph]
is_a: GO:0035107 ! appendage morphogenesis
relationship: part_of GO:0060173 ! limb development

[Term]
id: GO:0035109
name: imaginal disc-derived limb morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of limbs that are derived from an imaginal disc are generated and organized. Morphogenesis pertains to the creation of form. A limb is an appendage of an animal used for locomotion or grasping. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0035108 ! limb morphogenesis
is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis

[Term]
id: GO:0035110
name: leg morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of leg are generated and organized. Morphogenesis pertains to the creation of form. A leg is a limb on which an animal walks and stands." [GOC:bf, ISBN:0198612001]
is_a: GO:0035108 ! limb morphogenesis

[Term]
id: GO:0035111
name: leg joint morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of leg joint are generated and organized. Morphogenesis pertains to the creation of form. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. For example the knee, which separates the leg tibia and femur." [GOC:bf, ISBN:0582227089, PMID:12051824]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0035286 ! leg segmentation

[Term]
id: GO:0035112
name: genitalia morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of genitalia are generated and organized. Morphogenesis pertains to the creation of form. The genitalia are the organs of reproduction or generation, external and internal." [GOC:bf]
synonym: "genital morphogenesis" RELATED []
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0048806 ! genitalia development

[Term]
id: GO:0035113
name: embryonic appendage morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. Morphogenesis pertains to the creation of form. An appendage is an organ or part that is attached to the trunk of an organism. For example a limb or a branch." [ISBN:0582227089]
is_a: GO:0035107 ! appendage morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0035114
name: imaginal disc-derived appendage morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of appendages are generated and organized. Morphogenesis pertains to the creation of form. An appendage is an organ or part that is attached to the trunk of an organism." [GOC:mtg_sensu, ISBN:0582227089]
is_a: GO:0035107 ! appendage morphogenesis
is_a: GO:0048737 ! imaginal disc-derived appendage development

[Term]
id: GO:0035115
name: embryonic forelimb morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. Morphogenesis pertains to the creation of form. The forelimbs are the front limbs of an animal." [ISBN:0198612001]
is_a: GO:0030326 ! embryonic limb morphogenesis
is_a: GO:0035136 ! forelimb morphogenesis

[Term]
id: GO:0035116
name: embryonic hindlimb morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. Morphogenesis pertains to the creation of form. The hindlimbs are the posterior limbs of an animal." [ISBN:0198612001]
is_a: GO:0030326 ! embryonic limb morphogenesis
is_a: GO:0035137 ! hindlimb morphogenesis

[Term]
id: GO:0035117
name: embryonic arm morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the arm are generated and organized. Morphogenesis pertains to the creation of form. In humans, the arms are the two upper limbs of the body from the shoulder to the hand." [ISBN:0198612001]
is_a: GO:0035115 ! embryonic forelimb morphogenesis
is_a: GO:0035140 ! arm morphogenesis

[Term]
id: GO:0035118
name: embryonic pectoral fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Morphogenesis pertains to the creation of form. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0035115 ! embryonic forelimb morphogenesis
is_a: GO:0035138 ! pectoral fin morphogenesis

[Term]
id: GO:0035119
name: embryonic pelvic fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the pelvic fin are generated and organized. Morphogenesis pertains to the creation of form. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0035116 ! embryonic hindlimb morphogenesis
is_a: GO:0035139 ! pelvic fin morphogenesis

[Term]
id: GO:0035120
name: post-embryonic appendage morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of an appendage are generated and organized. Morphogenesis pertains to the creation of form. An appendage is an organ or part that is attached to the trunk of an organism. For example a limb or a branch." [ISBN:0582227089]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0035107 ! appendage morphogenesis

[Term]
id: GO:0035121
name: tail morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the tail are generated and organized. Morphogenesis pertains to the creation of form. The tail is the hindmost part of some animals." [ISBN:0198612001]
is_a: GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0035122
name: embryonic medial fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the medial fin are generated and organized. Morphogenesis pertains to the creation of form. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh]
synonym: "embryonic unpaired fin morphogenesis" EXACT []
is_a: GO:0035141 ! medial fin morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis

[Term]
id: GO:0035123
name: embryonic dorsal fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the dorsal fin are generated and organized. Morphogenesis pertains to the creation of form. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh]
is_a: GO:0035122 ! embryonic medial fin morphogenesis
is_a: GO:0035142 ! dorsal fin morphogenesis

[Term]
id: GO:0035124
name: embryonic caudal fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the caudal fin are generated and organized. Morphogenesis pertains to the creation of form. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion." [GOC:dgh]
is_a: GO:0035122 ! embryonic medial fin morphogenesis
is_a: GO:0035143 ! caudal fin morphogenesis

[Term]
id: GO:0035125
name: embryonic anal fin morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the embryonic anal fin are generated and organized. Morphogenesis pertains to the creation of form. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh]
is_a: GO:0035122 ! embryonic medial fin morphogenesis
is_a: GO:0035144 ! anal fin morphogenesis

[Term]
id: GO:0035126
name: post-embryonic genitalia morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the genitalia are generated and organized. Morphogenesis pertains to the creation of form." [GOC:bf]
synonym: "post-embryonic genital morphogenesis" RELATED []
is_a: GO:0035112 ! genitalia morphogenesis
is_a: GO:0048563 ! post-embryonic organ morphogenesis

[Term]
id: GO:0035127
name: post-embryonic limb morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the limb are generated and organized. Morphogenesis pertains to the creation of form. A limb is an appendage of an animal used for locomotion or grasping." [ISBN:0395825172]
is_a: GO:0035108 ! limb morphogenesis
is_a: GO:0035120 ! post-embryonic appendage morphogenesis

[Term]
id: GO:0035128
name: post-embryonic forelimb morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the forelimb are generated and organized. Morphogenesis pertains to the creation of form. The forelimbs are the front limbs of an organism." [GOC:bf]
is_a: GO:0035127 ! post-embryonic limb morphogenesis
is_a: GO:0035136 ! forelimb morphogenesis

[Term]
id: GO:0035129
name: post-embryonic hindlimb morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the hindlimb are generated and organized. Morphogenesis pertains to the creation of form." [GOC:bf]
is_a: GO:0035127 ! post-embryonic limb morphogenesis
is_a: GO:0035137 ! hindlimb morphogenesis

[Term]
id: GO:0035130
name: post-embryonic pectoral fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the pectoral fin are generated and organized. Morphogenesis pertains to the creation of form. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0035128 ! post-embryonic forelimb morphogenesis
is_a: GO:0035138 ! pectoral fin morphogenesis

[Term]
id: GO:0035131
name: post-embryonic pelvic fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the pelvic fin are generated and organized. Morphogenesis pertains to the creation of form. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0035129 ! post-embryonic hindlimb morphogenesis
is_a: GO:0035139 ! pelvic fin morphogenesis

[Term]
id: GO:0035132
name: post-embryonic medial fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the medial fin are generated and organized. Morphogenesis pertains to the creation of form. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh]
synonym: "post-embryonic unpaired fin morphogenesis" EXACT []
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0035141 ! medial fin morphogenesis

[Term]
id: GO:0035133
name: post-embryonic caudal fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the caudal fin are generated and organized. Morphogenesis pertains to the creation of form. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion." [GOC:dgh]
is_a: GO:0035132 ! post-embryonic medial fin morphogenesis
is_a: GO:0035143 ! caudal fin morphogenesis

[Term]
id: GO:0035134
name: post-embryonic dorsal fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the dorsal fin are generated and organized. Morphogenesis pertains to the creation of form. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh]
is_a: GO:0035132 ! post-embryonic medial fin morphogenesis
is_a: GO:0035142 ! dorsal fin morphogenesis

[Term]
id: GO:0035135
name: post-embryonic anal fin morphogenesis
namespace: biological_process
def: "The process, occurring after embryonic development, by which the anatomical structures of the anal fin are generated and organized. Morphogenesis pertains to the creation of form. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh]
is_a: GO:0035132 ! post-embryonic medial fin morphogenesis
is_a: GO:0035144 ! anal fin morphogenesis

[Term]
id: GO:0035136
name: forelimb morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the forelimb are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0035108 ! limb morphogenesis

[Term]
id: GO:0035137
name: hindlimb morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the hindlimb are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0035108 ! limb morphogenesis

[Term]
id: GO:0035138
name: pectoral fin morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the pectoral fin are generated and organized. Morphogenesis pertains to the creation of form. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0033334 ! fin morphogenesis
is_a: GO:0035136 ! forelimb morphogenesis
relationship: part_of GO:0033339 ! pectoral fin development

[Term]
id: GO:0035139
name: pelvic fin morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the pelvic fin are generated and organized. Morphogenesis pertains to the creation of form. Pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh]
is_a: GO:0033334 ! fin morphogenesis
is_a: GO:0035137 ! hindlimb morphogenesis
relationship: part_of GO:0033340 ! pelvic fin development

[Term]
id: GO:0035140
name: arm morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the arm are generated and organized. Morphogenesis pertains to the creation of form. In humans, the arms are the two upper limbs of the body from the shoulder to the hand." [ISBN:0198612001]
is_a: GO:0035136 ! forelimb morphogenesis

[Term]
id: GO:0035141
name: medial fin morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the medial fin are generated and organized. Morphogenesis pertains to the creation of form. A medial fin is an unpaired fin of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh]
synonym: "unpaired fin morphogenesis" EXACT []
is_a: GO:0033334 ! fin morphogenesis
relationship: part_of GO:0033338 ! medial fin development

[Term]
id: GO:0035142
name: dorsal fin morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the dorsal fin are generated and organized. Morphogenesis pertains to the creation of form. A dorsal fin is an unpaired medial fin on the dorsal aspect of fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh]
is_a: GO:0035141 ! medial fin morphogenesis
relationship: part_of GO:0033337 ! dorsal fin development

[Term]
id: GO:0035143
name: caudal fin morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the caudal fin are generated and organized. Morphogenesis pertains to the creation of form. A caudal fin is an unpaired medial fin mounted at the caudal end of the fish, and is the main fin used for propulsion." [GOC:dgh]
is_a: GO:0035141 ! medial fin morphogenesis
relationship: part_of GO:0033336 ! caudal fin development

[Term]
id: GO:0035144
name: anal fin morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the anal fin are generated and organized. Morphogenesis pertains to the creation of form. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh]
is_a: GO:0035141 ! medial fin morphogenesis
relationship: part_of GO:0033335 ! anal fin development

[Term]
id: GO:0035145
name: exon-exon junction complex
namespace: cellular_component
def: "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026]
synonym: "EJC" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0035146
name: tube fusion
namespace: biological_process
def: "The joining of specific branches of a tubular system to form a continuous network." [GOC:bf]
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0048754 ! branching morphogenesis of a tube

[Term]
id: GO:0035147
name: branch fusion, open tracheal system
namespace: biological_process
def: "Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584]
synonym: "tracheal branch fusion" EXACT []
is_a: GO:0035146 ! tube fusion
relationship: part_of GO:0060446 ! branching involved in open tracheal system development

[Term]
id: GO:0035148
name: tube formation
namespace: biological_process
def: "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf]
synonym: "lumen formation in an anatomical structure" RELATED [GOC:dph, GOC:mah]
synonym: "tube lumen formation" EXACT [GOC:dph, GOC:mah]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0035239 ! tube morphogenesis

[Term]
id: GO:0035149
name: lumen formation, open tracheal system
namespace: biological_process
def: "Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu]
synonym: "tracheal lumen formation" EXACT []
is_a: GO:0035148 ! tube formation
is_a: GO:0035152 ! regulation of tube architecture, open tracheal system

[Term]
id: GO:0035150
name: regulation of tube size
namespace: biological_process
def: "Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development and in some physiological processes." [PMID:10887083]
is_a: GO:0090066 ! regulation of anatomical structure size

[Term]
id: GO:0035151
name: regulation of tube size, open tracheal system
namespace: biological_process
def: "Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360]
synonym: "regulation of tracheal tube size" EXACT []
is_a: GO:0035150 ! regulation of tube size
is_a: GO:0035152 ! regulation of tube architecture, open tracheal system

[Term]
id: GO:0035152
name: regulation of tube architecture, open tracheal system
namespace: biological_process
def: "Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584]
synonym: "regulation of tracheal tube architecture" EXACT []
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035153
name: epithelial cell type specification, open tracheal system
namespace: biological_process
def: "Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions." [GOC:mtg_sensu, PMID:10684581, PMID:11063940]
synonym: "tracheal cell type specification" BROAD []
synonym: "tracheal epithelial cell type specification" EXACT []
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035154
name: terminal cell fate specification, open tracheal system
namespace: biological_process
def: "Process by which a cell in an open tracheal system becomes capable of differentiating autonomously into a terminal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Terminal cells send long and bifurcated hollow branches toward target tissues to allow oxygen exchange." [GOC:mtg_sensu, PMID:10684581, PMID:11063940]
synonym: "terminal cell fate specification" EXACT []
is_a: GO:0035153 ! epithelial cell type specification, open tracheal system

[Term]
id: GO:0035155
name: negative regulation of terminal cell fate specification, open tracheal system
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from adopting a terminal cell fate in an open tracheal system. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [GOC:mtg_sensu, PMID:10684581]
synonym: "down regulation of terminal cell fate specification" EXACT []
synonym: "down-regulation of terminal cell fate specification" EXACT []
synonym: "downregulation of terminal cell fate specification" EXACT []
synonym: "inhibition of terminal cell fate specification" NARROW []
synonym: "negative regulation of terminal cell fate specification" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: negatively_regulates GO:0035154 ! terminal cell fate specification, open tracheal system

[Term]
id: GO:0035156
name: fusion cell fate specification
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a fusion cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Fusion cells allow the interconnection of adjacent tracheal metameres during tracheal tube fusion." [PMID:11063940]
is_a: GO:0035153 ! epithelial cell type specification, open tracheal system

[Term]
id: GO:0035157
name: negative regulation of fusion cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from adopting a fusion cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [PMID:10684581]
synonym: "down regulation of fusion cell fate specification" EXACT []
synonym: "down-regulation of fusion cell fate specification" EXACT []
synonym: "downregulation of fusion cell fate specification" EXACT []
synonym: "inhibition of fusion cell fate specification" NARROW []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: negatively_regulates GO:0035156 ! fusion cell fate specification

[Term]
id: GO:0035158
name: regulation of tube diameter, open tracheal system
namespace: biological_process
def: "Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584]
synonym: "regulation of tracheal tube diameter" EXACT []
synonym: "tracheal tube dilation" NARROW []
synonym: "tracheal tube expansion" NARROW []
is_a: GO:0035296 ! regulation of tube diameter
relationship: part_of GO:0035151 ! regulation of tube size, open tracheal system

[Term]
id: GO:0035159
name: regulation of tube length, open tracheal system
namespace: biological_process
def: "Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu]
synonym: "regulation of tracheal tube length" EXACT []
synonym: "tracheal tube elongation" NARROW []
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0035151 ! regulation of tube size, open tracheal system

[Term]
id: GO:0035160
name: maintenance of epithelial integrity, open tracheal system
namespace: biological_process
def: "Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process." [GOC:mtg_sensu, PMID:10694415, PMID:14681183]
synonym: "maintenance of tracheal epithelial integrity" EXACT []
is_a: GO:0010669 ! epithelial structure maintenance
is_a: GO:0035152 ! regulation of tube architecture, open tracheal system

[Term]
id: GO:0035161
name: imaginal disc lineage restriction
namespace: biological_process
def: "Formation and/or maintenance of a lineage boundary between compartments in an imaginal disc that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0007447 ! imaginal disc pattern formation

[Term]
id: GO:0035162
name: embryonic hemopoiesis
namespace: biological_process
def: "The stages of blood cell formation that take place within the embryo." [GOC:bf]
synonym: "embryonic haematopoiesis" EXACT []
synonym: "embryonic haemopoiesis" EXACT []
synonym: "embryonic hematopoiesis" EXACT []
is_a: GO:0030097 ! hemopoiesis
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:0035163
name: embryonic hemocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell derived from the embryonic head mesoderm acquires the specialized features of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu, PMID:14602069]
synonym: "embryonic arthropod blood cell differentiation" EXACT []
synonym: "embryonic hemocyte cell differentiation" EXACT []
is_a: GO:0042386 ! hemocyte differentiation
relationship: part_of GO:0035162 ! embryonic hemopoiesis

[Term]
id: GO:0035164
name: embryonic plasmatocyte differentiation
namespace: biological_process
def: "The process whereby an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte." [GOC:bf, PMID:11921077, PMID:8174791]
synonym: "embryonic plasmatocyte cell differentiation" EXACT []
is_a: GO:0035163 ! embryonic hemocyte differentiation
is_a: GO:0042387 ! plasmatocyte differentiation

[Term]
id: GO:0035165
name: embryonic crystal cell differentiation
namespace: biological_process
def: "The process whereby an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
is_a: GO:0035163 ! embryonic hemocyte differentiation
is_a: GO:0042688 ! crystal cell differentiation

[Term]
id: GO:0035166
name: post-embryonic hemopoiesis
namespace: biological_process
def: "The stages of blood cell formation that take place after completion of embryonic development." [GOC:bf]
synonym: "post-embryonic haemopoiesis" EXACT []
is_a: GO:0030097 ! hemopoiesis
is_a: GO:0048569 ! post-embryonic organ development
relationship: part_of GO:0009791 ! post-embryonic development

[Term]
id: GO:0035167
name: larval lymph gland hemopoiesis
namespace: biological_process
def: "The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385]
synonym: "larval lymph gland haematopoiesis" EXACT []
synonym: "larval lymph gland haemopoiesis" EXACT []
synonym: "larval lymph gland hematopoiesis" EXACT []
is_a: GO:0035166 ! post-embryonic hemopoiesis
relationship: part_of GO:0002164 ! larval development
relationship: part_of GO:0048542 ! lymph gland development

[Term]
id: GO:0035168
name: larval lymph gland hemocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell derived from the larval lymph gland acquires the specialized features of a mature hemocyte. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:14602069]
synonym: "larval lymph gland arthropod blood cell differentiation" EXACT []
is_a: GO:0042386 ! hemocyte differentiation
relationship: part_of GO:0035167 ! larval lymph gland hemopoiesis

[Term]
id: GO:0035169
name: lymph gland plasmatocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte." [GOC:bf, PMID:11921077, PMID:8174791]
synonym: "lymph gland plasmatocyte cell differentiation" EXACT []
is_a: GO:0035168 ! larval lymph gland hemocyte differentiation
is_a: GO:0042387 ! plasmatocyte differentiation

[Term]
id: GO:0035170
name: lymph gland crystal cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
is_a: GO:0035168 ! larval lymph gland hemocyte differentiation
is_a: GO:0042688 ! crystal cell differentiation

[Term]
id: GO:0035171
name: lamellocyte differentiation
namespace: biological_process
def: "The process by which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104]
synonym: "lamellocyte cell differentiation" EXACT []
is_a: GO:0035168 ! larval lymph gland hemocyte differentiation

[Term]
id: GO:0035172
name: hemocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu]
synonym: "arthropod blood cell proliferation" EXACT []
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0035173
name: histone kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf]
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0035174
name: histone serine kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf]
synonym: "histone-serine kinase activity" EXACT []
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0035173 ! histone kinase activity

[Term]
id: GO:0035175
name: histone kinase activity (H3-S10 specific)
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3." [GOC:bf, PMID:15041176]
synonym: "histone serine kinase activity (H3-S10 specific)" EXACT []
synonym: "histone-serine kinase activity (H3-S10 specific)" EXACT []
is_a: GO:0035174 ! histone serine kinase activity

[Term]
id: GO:0035176
name: social behavior
namespace: biological_process
def: "Behavior that occurs predominantly, or only, in individuals that are part of a group." [PMID:12848939]
synonym: "cooperative behavior" RELATED []
synonym: "social behaviour" EXACT []
xref: Wikipedia:Social_behavior
is_a: GO:0051705 ! behavioral interaction between organisms

[Term]
id: GO:0035177
name: larval foraging behavior
namespace: biological_process
def: "The movement of a larva through a feeding substrate whilst feeding on food." [PMID:12848927]
synonym: "larval foraging behaviour" EXACT []
is_a: GO:0030537 ! larval behavior
is_a: GO:0060756 ! foraging behavior

[Term]
id: GO:0035178
name: turning behavior
namespace: biological_process
def: "Fine-tuning the spatial position of an organism in response to variability in their environment. For example, reorientation of an organism in the direction of a food source." [PMID:10880478]
synonym: "turning behaviour" EXACT []
is_a: GO:0007626 ! locomotory behavior

[Term]
id: GO:0035179
name: larval turning behavior
namespace: biological_process
def: "Fine-tuning the spatial position of a larva in response to variability in their environment. For example, reorientation of a larva in the direction of a food source." [PMID:10880478]
synonym: "larval turning behaviour" EXACT []
is_a: GO:0008345 ! larval locomotory behavior
is_a: GO:0035178 ! turning behavior

[Term]
id: GO:0035180
name: larval wandering behavior
namespace: biological_process
def: "The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction." [PMID:12848927, PMID:12956960]
synonym: "larval wandering behaviour" EXACT []
is_a: GO:0008345 ! larval locomotory behavior

[Term]
id: GO:0035181
name: larval burrowing behavior
namespace: biological_process
def: "Digging into the substrate by non-feeding larvae in search for food-free sites suitable for pupation." [PMID:12848927, PMID:12848939]
synonym: "larval burrowing behaviour" EXACT []
is_a: GO:0008345 ! larval locomotory behavior

[Term]
id: GO:0035182
name: female germline ring canal outer rim
namespace: cellular_component
def: "An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues." [PMID:12435357, PMID:7925006]
comment: See also the fly_anatomy.ontology term 'outer nurse cell ring canal rim ; FBbt:00004882'.
synonym: "germline ring canal outer rim" BROAD []
synonym: "nurse cell ring canal outer rim" NARROW []
synonym: "ovarian ring canal outer rim" NARROW []
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0035324 ! female germline ring canal

[Term]
id: GO:0035183
name: female germline ring canal inner rim
namespace: cellular_component
def: "A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins." [PMID:10556087, PMID:7925006, PMID:9093858]
comment: See also the fly_anatomy.ontology term 'inner nurse cell ring canal rim ; FBbt:00004881'.
synonym: "germline ring canal inner rim" BROAD []
synonym: "nurse cell ring canal inner rim" NARROW []
synonym: "ovarian ring canal inner rim" NARROW []
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0035324 ! female germline ring canal

[Term]
id: GO:0035184
name: histone threonine kinase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to a threonine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf]
synonym: "histone-threonine kinase activity" EXACT []
is_a: GO:0004674 ! protein serine/threonine kinase activity
is_a: GO:0035173 ! histone kinase activity

[Term]
id: GO:0035185
name: preblastoderm mitotic cell cycle
namespace: biological_process
def: "The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis." [ISBN:0879694238]
is_a: GO:0033301 ! cell cycle comprising mitosis without cytokinesis
is_a: GO:0045448 ! mitotic cell cycle, embryonic

[Term]
id: GO:0035186
name: syncytial blastoderm mitotic cell cycle
namespace: biological_process
def: "Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238]
is_a: GO:0033301 ! cell cycle comprising mitosis without cytokinesis
is_a: GO:0045448 ! mitotic cell cycle, embryonic

[Term]
id: GO:0035187
name: hatching behavior
namespace: biological_process
def: "The specific actions or reactions of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell." [PMID:10436051]
synonym: "hatching behaviour" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0035188 ! hatching

[Term]
id: GO:0035188
name: hatching
namespace: biological_process
def: "The emergence of an immature organism from a protective structure." [GOC:dgh, GOC:isa_complete, ISBN:0198612001]
is_a: GO:0071684 ! organism emergence from protective structure
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0035189
name: Rb-E2F complex
namespace: cellular_component
def: "A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression." [PMID:14616073]
synonym: "retinoblastoma-E2F complex" EXACT []
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0035190
name: syncytial nuclear migration
namespace: biological_process
def: "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex." [GOC:bf, ISBN:0879694238, PMID:8314839]
is_a: GO:0007097 ! nuclear migration
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0035191
name: nuclear axial expansion
namespace: biological_process
def: "The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex." [PMID:8314839]
synonym: "nuclear distribution along anterior-posterior axis" EXACT []
synonym: "nucleus distribution along anterior-posterior axis" EXACT []
is_a: GO:0035190 ! syncytial nuclear migration

[Term]
id: GO:0035192
name: nuclear cortical migration
namespace: biological_process
def: "The symmetric outward movement of the syncytial nuclei from their positions in the ellipsoid toward the periphery of the embryo, during mitotic cycles 8 and 9. This movement results in the placement of nuclei in a uniform monolayer at the cortex of the developing embryo." [PMID:8314839]
is_a: GO:0035190 ! syncytial nuclear migration

[Term]
id: GO:0035193
name: larval central nervous system remodeling
namespace: biological_process
def: "Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. An example of this process is found in Drosophila melanogaster." [GOC:sensu, PMID:9647692]
synonym: "central nervous system metamorphosis" EXACT []
synonym: "CNS metamorphosis" EXACT []
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0002165 ! instar larval or pupal development
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0035194
name: posttranscriptional gene silencing by RNA
namespace: biological_process
def: "Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation." [GOC:mah, PMID:15020054, PMID:15066275, PMID:15066283]
synonym: "RNA-mediated posttranscriptional gene silencing" EXACT [GOC:dph, GOC:tb]
synonym: "sense-PTGS" RELATED []
is_a: GO:0016441 ! posttranscriptional gene silencing
is_a: GO:0031047 ! gene silencing by RNA

[Term]
id: GO:0035195
name: gene silencing by miRNA
namespace: biological_process
def: "Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression." [PMID:14744438, PMID:15066275, PMID:15066283]
synonym: "microRNA-mediated gene silencing" EXACT []
synonym: "miRNA-mediated gene silencing" EXACT [GOC:dph, GOC:tb]
is_a: GO:0035194 ! posttranscriptional gene silencing by RNA

[Term]
id: GO:0035196
name: production of miRNAs involved in gene silencing by miRNA
namespace: biological_process
alt_id: GO:0030918
def: "Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein." [GOC:dph, GOC:tb, PMID:15066275, PMID:15066283]
synonym: "gene silencing by miRNA, production of miRNAs" EXACT [GOC:mah]
synonym: "microRNA biogenesis" RELATED [GOC:tb]
synonym: "microRNA biosynthesis" RELATED []
synonym: "microRNA biosynthetic process" RELATED []
synonym: "microRNA metabolic process" RELATED []
synonym: "microRNA metabolism" RELATED []
synonym: "microRNA processing" BROAD []
synonym: "microRNA-mediated gene silencing, production of microRNAs" EXACT []
synonym: "miRNA biogenesis" RELATED [GOC:tb]
synonym: "miRNA processing" EXACT []
synonym: "miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:dph, GOC:tb]
is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA
relationship: part_of GO:0035195 ! gene silencing by miRNA

[Term]
id: GO:0035197
name: siRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme." [PMID:15066275, PMID:15066283]
synonym: "small interfering RNA binding" EXACT []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0035198
name: miRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283]
synonym: "microRNA binding" EXACT []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0035199
name: salt aversion
namespace: biological_process
def: "The specific avoidance actions or reactions of an organism in response to the perception of salt." [GOC:bf]
synonym: "behavioral response to salt" BROAD []
is_a: GO:0007631 ! feeding behavior
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0035200
name: leg disc anterior/posterior pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the leg imaginal disc." [GOC:bf]
is_a: GO:0007448 ! anterior/posterior pattern formation, imaginal disc
is_a: GO:0035223 ! leg disc pattern formation

[Term]
id: GO:0035201
name: leg disc anterior/posterior lineage restriction
namespace: biological_process
def: "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments of the leg disc that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf]
is_a: GO:0048099 ! anterior/posterior lineage restriction, imaginal disc
relationship: part_of GO:0035200 ! leg disc anterior/posterior pattern formation

[Term]
id: GO:0035202
name: sac formation, open tracheal system
namespace: biological_process
def: "Formation of the tracheal sacs, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal sacs arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940, PMID:11992723, PMID:14570584]
synonym: "tracheal placode invagination" RELATED []
synonym: "tracheal sac formation" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035203
name: regulation of lamellocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104]
is_a: GO:0045610 ! regulation of hemocyte differentiation
is_a: GO:0048580 ! regulation of post-embryonic development
relationship: regulates GO:0035171 ! lamellocyte differentiation

[Term]
id: GO:0035204
name: negative regulation of lamellocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104]
synonym: "down regulation of lamellocyte differentiation" EXACT []
synonym: "down-regulation of lamellocyte differentiation" EXACT []
synonym: "downregulation of lamellocyte differentiation" EXACT []
synonym: "inhibition of lamellocyte differentiation" NARROW []
is_a: GO:0035203 ! regulation of lamellocyte differentiation
is_a: GO:0045611 ! negative regulation of hemocyte differentiation
relationship: negatively_regulates GO:0035171 ! lamellocyte differentiation

[Term]
id: GO:0035205
name: positive regulation of lamellocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104]
synonym: "activation of lamellocyte differentiation" NARROW []
synonym: "stimulation of lamellocyte differentiation" NARROW []
synonym: "up regulation of lamellocyte differentiation" EXACT []
synonym: "up-regulation of lamellocyte differentiation" EXACT []
synonym: "upregulation of lamellocyte differentiation" EXACT []
is_a: GO:0035203 ! regulation of lamellocyte differentiation
is_a: GO:0045612 ! positive regulation of hemocyte differentiation
relationship: positively_regulates GO:0035171 ! lamellocyte differentiation

[Term]
id: GO:0035206
name: regulation of hemocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "regulation of arthropod blood cell proliferation" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0035172 ! hemocyte proliferation

[Term]
id: GO:0035207
name: negative regulation of hemocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "down regulation of hemocyte proliferation" EXACT []
synonym: "down-regulation of hemocyte proliferation" EXACT []
synonym: "downregulation of hemocyte proliferation" EXACT []
synonym: "inhibition of hemocyte proliferation" NARROW []
synonym: "negative regulation of arthropod blood cell proliferation" EXACT []
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0035206 ! regulation of hemocyte proliferation
relationship: negatively_regulates GO:0035172 ! hemocyte proliferation

[Term]
id: GO:0035208
name: positive regulation of hemocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "activation of hemocyte proliferation" NARROW []
synonym: "positive regulation of arthropod blood cell proliferation" EXACT []
synonym: "stimulation of hemocyte proliferation" NARROW []
synonym: "up regulation of hemocyte proliferation" EXACT []
synonym: "up-regulation of hemocyte proliferation" EXACT []
synonym: "upregulation of hemocyte proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0035206 ! regulation of hemocyte proliferation
relationship: positively_regulates GO:0035172 ! hemocyte proliferation

[Term]
id: GO:0035209
name: pupal development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0035210
name: prepupal development
namespace: biological_process
def: "The process whose specific outcome is the progression of the prepupa over time, from its formation to the mature structure. The prepupal stage is a life stage interposed between the larval and the pupal stages in insects that undergo a complete metamorphosis. The start of the pre-pupal stage is marked by pupariation, and the end is marked by pupation." [GOC:mtg_sensu, http://sdb.bio.purdue.edu/fly/aimain/1adult.htm]
comment: See also the fly_anatomy.ontology term 'prepupa ; FBbt:00002952'.
is_a: GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0035211
name: spermathecum morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk." [PMID:12679097]
comment: See also the fly_anatomy.ontology term 'spermathecum ; FBbt:00004921'.
is_a: GO:0009887 ! organ morphogenesis

[Term]
id: GO:0035212
name: cell competition in a multicellular organism
namespace: biological_process
def: "Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286]
is_a: GO:0009987 ! cellular process
is_a: GO:0040008 ! regulation of growth
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0035213
name: clypeo-labral disc development
namespace: biological_process
def: "The process whose specific outcome is the progression of the clypeo-labral disc over time, from its formation to the metamorphosis to form adult structures. The clypeo-labral disc develops into the labrum, anterior cibarial plate, fish trap bristles, epistomal sclerite." [GOC:bf, ISBN:0879694238]
synonym: "development of structures derived from the clypeo-labral disc" EXACT []
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035214
name: eye-antennal disc development
namespace: biological_process
def: "Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035215
name: genital disc development
namespace: biological_process
def: "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035216
name: haltere disc development
namespace: biological_process
def: "Progression of the haltere imaginal disc over time, from its initial formation through to its metamorphosis to form the adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035217
name: labial disc development
namespace: biological_process
def: "Progression of the labial imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035218
name: leg disc development
namespace: biological_process
def: "Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035219
name: prothoracic disc development
namespace: biological_process
def: "Progression of the prothoracic disc over time, from its initial formation through to its metamorphosis to form the adult humerous and anterior spiracle." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035220
name: wing disc development
namespace: biological_process
def: "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238]
is_a: GO:0007444 ! imaginal disc development

[Term]
id: GO:0035221
name: genital disc pattern formation
namespace: biological_process
def: "The process that gives rise to the patterns of cell differentiation that will arise in the genital imaginal disc." [GOC:bf]
is_a: GO:0007447 ! imaginal disc pattern formation
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0035222
name: wing disc pattern formation
namespace: biological_process
def: "The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf]
is_a: GO:0007447 ! imaginal disc pattern formation
relationship: part_of GO:0035220 ! wing disc development

[Term]
id: GO:0035223
name: leg disc pattern formation
namespace: biological_process
def: "The process that gives rise to the patterns of cell differentiation in the leg imaginal disc." [GOC:bf]
is_a: GO:0007447 ! imaginal disc pattern formation
relationship: part_of GO:0035218 ! leg disc development

[Term]
id: GO:0035224
name: genital disc anterior/posterior pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium)." [PMID:11494318]
is_a: GO:0007448 ! anterior/posterior pattern formation, imaginal disc
is_a: GO:0035221 ! genital disc pattern formation

[Term]
id: GO:0035225
name: determination of genital disc primordium
namespace: biological_process
def: "Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318]
is_a: GO:0007445 ! determination of imaginal disc primordium
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0035226
name: glutamate-cysteine ligase catalytic subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the catalytic subunit of glutamate-cysteine ligase." [PMID:12954617]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0035227
name: regulation of glutamate-cysteine ligase activity
namespace: biological_process
def: "Any process that modulates the activity of glutamate-cysteine ligase." [GOC:bf]
subset: gosubset_prok
is_a: GO:0051340 ! regulation of ligase activity

[Term]
id: GO:0035228
name: negative regulation of glutamate-cysteine ligase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme glutamate-cysteine ligase." [GOC:bf]
subset: gosubset_prok
synonym: "down regulation of glutamate-cysteine ligase activity" EXACT []
synonym: "down-regulation of glutamate-cysteine ligase activity" EXACT []
synonym: "downregulation of glutamate-cysteine ligase activity" EXACT []
synonym: "inhibition of glutamate-cysteine ligase activity" NARROW []
is_a: GO:0035227 ! regulation of glutamate-cysteine ligase activity
is_a: GO:0051352 ! negative regulation of ligase activity

[Term]
id: GO:0035229
name: positive regulation of glutamate-cysteine ligase activity
namespace: biological_process
def: "Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate." [PMID:12954617]
subset: gosubset_prok
synonym: "activation of glutamate-cysteine ligase activity" NARROW []
synonym: "stimulation of glutamate-cysteine ligase activity" NARROW []
synonym: "up regulation of glutamate-cysteine ligase activity" EXACT []
synonym: "up-regulation of glutamate-cysteine ligase activity" EXACT []
synonym: "upregulation of glutamate-cysteine ligase activity" EXACT []
is_a: GO:0035227 ! regulation of glutamate-cysteine ligase activity
is_a: GO:0051351 ! positive regulation of ligase activity

[Term]
id: GO:0035230
name: cytoneme
namespace: cellular_component
def: "A long, thin, polarized cell projection that contains actin and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um." [PMID:10367889, PMID:10675901]
subset: goslim_pir
synonym: "membrane nanotube" EXACT [Wikipedia:Membrane_nanotube]
xref: Wikipedia:Membrane_nanotube
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0035231
name: cytoneme assembly
namespace: biological_process
def: "Formation of a cytoneme, a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [PMID:10367889, PMID:10675901]
synonym: "cytoneme biogenesis" RELATED [GOC:mah]
is_a: GO:0030031 ! cell projection assembly
relationship: part_of GO:0003399 ! cytoneme morphogenesis

[Term]
id: GO:0035232
name: germ cell attraction
namespace: biological_process
def: "The directed movement of a germ cell from their site of production to the gonad, through the attraction of cells towards their target." [PMID:12885551]
is_a: GO:0050918 ! positive chemotaxis
is_a: GO:0060326 ! cell chemotaxis
relationship: part_of GO:0008354 ! germ cell migration

[Term]
id: GO:0035233
name: germ cell repulsion
namespace: biological_process
def: "The directed movement of a germ cell from their site of production to the gonad, through the repulsion of cells away from a tissue." [PMID:12885551]
is_a: GO:0050919 ! negative chemotaxis
is_a: GO:0060326 ! cell chemotaxis
relationship: part_of GO:0008354 ! germ cell migration

[Term]
id: GO:0035234
name: germ cell programmed cell death
namespace: biological_process
def: "Programmed cell death of an errant germ line cell that are outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944]
synonym: "programmed cell death of germ cells" EXACT []
synonym: "programmed cell death, germ cells" EXACT []
is_a: GO:0010623 ! developmental programmed cell death
relationship: part_of GO:0008354 ! germ cell migration

[Term]
id: GO:0035235
name: ionotropic glutamate receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor, followed by the movement of ions through a channel in the receptor complex." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "ionotropic glutamate receptor signalling pathway" EXACT []
is_a: GO:0007215 ! glutamate signaling pathway

[Term]
id: GO:0035236
name: proctolin receptor activity
namespace: molecular_function
def: "Combining with the neuropeptide proctolin, to initiate a change in cell activity." [GOC:bf]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0035237
name: corazonin receptor activity
namespace: molecular_function
def: "Combining with the neuropeptide corazonin to initiate a change in cell activity." [GOC:bf]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0035238
name: vitamin A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid. Animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids." [PMID:11158606]
subset: gosubset_prok
synonym: "vitamin A anabolism" EXACT []
synonym: "vitamin A biosynthesis" EXACT []
synonym: "vitamin A formation" EXACT []
synonym: "vitamin A synthesis" EXACT []
is_a: GO:0006776 ! vitamin A metabolic process
is_a: GO:0008299 ! isoprenoid biosynthetic process
is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process

[Term]
id: GO:0035239
name: tube morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a tube are generated and organized. Morphogenesis pertains to the creation of form. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0035295 ! tube development

[Term]
id: GO:0035240
name: dopamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0043176 ! amine binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0035241
name: protein-arginine omega-N monomethyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue." [PMID:14705965, RESID:AA0069]
xref: RESID:AA0069
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity

[Term]
id: GO:0035242
name: protein-arginine omega-N asymmetric methyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues." [PMID:14705965, RESID:AA0068, RESID:AA0069]
comment: Note that type I protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N asymmetric methyltransferase activity ; GO:0035242'.
synonym: "type I PRMT activity" RELATED []
synonym: "type I protein arginine methyltransferase activity" RELATED []
xref: RESID:AA0068
xref: RESID:AA0069
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity

[Term]
id: GO:0035243
name: protein-arginine omega-N symmetric methyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues." [PMID:14705965, RESID:AA0067, RESID:AA0069]
comment: Note that type II protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N symmetric methyltransferase activity ; GO:0035243'.
synonym: "type II PRMT activity" RELATED []
synonym: "type II protein arginine methyltransferase activity" RELATED []
xref: RESID:AA0067
xref: RESID:AA0069
is_a: GO:0016274 ! protein-arginine N-methyltransferase activity

[Term]
id: GO:0035244
name: peptidyl-arginine C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein." [GOC:bf]
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0008276 ! protein methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0035245
name: peptidyl-arginine C-methylation
namespace: biological_process
def: "The addition of a methyl group onto a carbon atom of an arginine residue in a protein." [GOC:bf]
subset: gosubset_prok
is_a: GO:0018216 ! peptidyl-arginine methylation

[Term]
id: GO:0035246
name: peptidyl-arginine N-methylation
namespace: biological_process
def: "The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein." [GOC:bf]
subset: gosubset_prok
is_a: GO:0018216 ! peptidyl-arginine methylation

[Term]
id: GO:0035247
name: peptidyl-arginine omega-N-methylation
namespace: biological_process
def: "The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein." [PMID:14705965, RESID:AA0067, RESID:AA0068, RESID:AA0069]
subset: gosubset_prok
xref: RESID:AA0067
xref: RESID:AA0068
xref: RESID:AA0069
is_a: GO:0035246 ! peptidyl-arginine N-methylation

[Term]
id: GO:0035248
name: alpha-1,4-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage." [PMID:15130086]
synonym: "alpha-1,4-GalNAc transferase activity" EXACT []
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0035249
name: synaptic transmission, glutamatergic
namespace: biological_process
def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:kmv]
is_a: GO:0007270 ! nerve-nerve synaptic transmission

[Term]
id: GO:0035250
name: UDP-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html]
subset: gosubset_prok
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0035251
name: UDP-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html]
subset: gosubset_prok
xref: MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0035252
name: UDP-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html]
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0042285 ! xylosyltransferase activity

[Term]
id: GO:0035253
name: ciliary rootlet
namespace: cellular_component
def: "A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [PMID:12427867]
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044441 ! cilium part

[Term]
id: GO:0035254
name: glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a glutamate receptor." [GOC:bf]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0035255
name: ionotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0035254 ! glutamate receptor binding

[Term]
id: GO:0035256
name: metabotropic glutamate receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a metabotropic glutamate receptor. Metabotropic glutamate receptors are G-protein coupled receptors that bind glutamate and exert an effect through the regulation of enzyme activity." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:9069287]
is_a: GO:0001664 ! G-protein-coupled receptor binding
is_a: GO:0035254 ! glutamate receptor binding

[Term]
id: GO:0035257
name: nuclear hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell." [GOC:bf]
is_a: GO:0051427 ! hormone receptor binding

[Term]
id: GO:0035258
name: steroid hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a steroid hormone receptor." [GOC:bf]
is_a: GO:0035257 ! nuclear hormone receptor binding

[Term]
id: GO:0035259
name: glucocorticoid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a glucocorticoid receptor." [GOC:bf]
is_a: GO:0035258 ! steroid hormone receptor binding

[Term]
id: GO:0035260
name: internal genitalia morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." [http://www.ndif.org/Terms/genitalia.html]
is_a: GO:0035112 ! genitalia morphogenesis

[Term]
id: GO:0035261
name: external genitalia morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals." [http://www.ndif.org/Terms/genitalia.html]
is_a: GO:0035112 ! genitalia morphogenesis

[Term]
id: GO:0035262
name: gonad morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals." [ISBN:0198612001]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0008406 ! gonad development

[Term]
id: GO:0035263
name: genital disc sexually dimorphic development
namespace: biological_process
def: "The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0007548 ! sex differentiation
relationship: part_of GO:0035215 ! genital disc development

[Term]
id: GO:0035264
name: multicellular organism growth
namespace: biological_process
def: "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb]
synonym: "body growth" RELATED []
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0040007 ! growth

[Term]
id: GO:0035265
name: organ growth
namespace: biological_process
def: "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GOC:bf, ISBN:0471245208, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0040007 ! growth

[Term]
id: GO:0035266
name: meristem growth
namespace: biological_process
def: "The increase in size or mass of a meristem, a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation." [GOC:bf, ISBN:0198547684]
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0048507 ! meristem development

[Term]
id: GO:0035267
name: NuA4 histone acetyltransferase complex
namespace: cellular_component
def: "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270]
synonym: "TIP60 histone acetylase complex" EXACT []
synonym: "TIP60 histone acetyltransferase complex" EXACT []
is_a: GO:0043189 ! H4/H2A histone acetyltransferase complex

[Term]
id: GO:0035268
name: protein amino acid mannosylation
namespace: biological_process
def: "The addition of a mannose residue to a protein acceptor molecule." [GOC:bf]
subset: gosubset_prok
is_a: GO:0006486 ! protein amino acid glycosylation

[Term]
id: GO:0035269
name: protein amino acid O-linked mannosylation
namespace: biological_process
def: "The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797]
subset: gosubset_prok
is_a: GO:0006493 ! protein amino acid O-linked glycosylation
is_a: GO:0035268 ! protein amino acid mannosylation

[Term]
id: GO:0035270
name: endocrine system development
namespace: biological_process
def: "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, http://encyclopedia.thefreedictionary.com/Endocrine+sytem, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0048731 ! system development

[Term]
id: GO:0035271
name: ring gland development
namespace: biological_process
def: "Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones." [GOC:bf, PMID:11223816, PMID:9584098]
comment: See also the fly_anatomy.ontology terms 'ring gland ; FBbt:00001722, 'prothoracic gland ; FBbt:00001724', 'corpus allatum ; FBbt:00005800' and 'corpus cardiacum ; FBbt:00005799.
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0035272
name: exocrine system development
namespace: biological_process
def: "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system." [GOC:bf, http://encyclopedia.thefreedictionary.com/Exocrine+gland, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0048731 ! system development

[Term]
id: GO:0035273
name: phthalate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phthalate, any ester or salt of phthalic acid." [http://umbbd.ahc.umn.edu/pth/pth_map.html]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0035274
name: diphenyl phthalate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with diphenyl phthalate, C(20)H(14)O(4)." [http://www.sigmaaldrich.com]
synonym: "DPP binding" EXACT []
is_a: GO:0035273 ! phthalate binding

[Term]
id: GO:0035275
name: dibutyl phthalate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dibutyl phthalate, C(16)H(22)O(4)." [http://www.sigmaaldrich.com]
synonym: "DBP binding" EXACT []
synonym: "phthalic acid dibutyl ester binding" EXACT []
is_a: GO:0035273 ! phthalate binding

[Term]
id: GO:0035276
name: ethanol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ethanol, CH(3)-CH(2)-OH." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0035277
name: spiracle morphogenesis, open tracheal system
namespace: biological_process
def: "The process by which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268]
synonym: "spiracle morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0035278
name: negative regulation of translation involved in gene silencing by miRNA
namespace: biological_process
def: "The process by which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically repress translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs." [PMID:14744438, PMID:15196554]
synonym: "down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah]
synonym: "down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah]
synonym: "downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah]
synonym: "gene silencing by miRNA, negative regulation of translation" EXACT [GOC:mah]
synonym: "inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:mah]
synonym: "miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0040033 ! negative regulation of translation, ncRNA-mediated
relationship: part_of GO:0035195 ! gene silencing by miRNA

[Term]
id: GO:0035279
name: mRNA cleavage involved in gene silencing by miRNA
namespace: biological_process
def: "The process by which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically direct cleavage by base pairing with near-perfect complementarity to the target mRNA. Many plant miRNAs downregulate gene expression through this mechanism." [GOC:dph, GOC:mtg_lung, PMID:14744438, PMID:15196554]
synonym: "gene silencing by miRNA, mRNA cleavage" EXACT [GOC:mah]
synonym: "miRNA-mediated gene silencing, mRNA cleavage" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006379 ! mRNA cleavage
relationship: part_of GO:0035195 ! gene silencing by miRNA

[Term]
id: GO:0035280
name: miRNA loading onto RISC involved in gene silencing by miRNA
namespace: biological_process
def: "The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC)." [PMID:14744438]
synonym: "gene silencing by miRNA, miRNA loading onto RISC" EXACT [GOC:mah]
synonym: "miRISC assembly" BROAD []
synonym: "miRNA-mediated gene silencing, miRNA loading onto RISC" EXACT [GOC:dph, GOC:tb]
is_a: GO:0070922 ! small RNA loading onto RISC
relationship: part_of GO:0035195 ! gene silencing by miRNA

[Term]
id: GO:0035281
name: pre-microRNA export from nucleus
namespace: biological_process
def: "Transport of pre-microRNAs (pre-miRNAs) from the nucleus to the cytoplasm. Pre-miRNAs are a ~60-70 nucleotide stem loop intermediate in miRNA production, produced by the nuclear cleavage of a primary miRNA (pri-mRNA) transcript. Pre-miRNAs are transported from the nucleus to the cytoplasm where further cleavage occurs to produce a mature miRNA product." [PMID:14744438]
synonym: "pre-microRNA export from cell nucleus" EXACT []
synonym: "pre-microRNA export out of nucleus" EXACT []
synonym: "pre-microRNA transport from nucleus to cytoplasm" EXACT []
synonym: "pre-microRNA-nucleus export" EXACT []
is_a: GO:0006405 ! RNA export from nucleus
relationship: part_of GO:0035195 ! gene silencing by miRNA

[Term]
id: GO:0035282
name: segmentation
namespace: biological_process
def: "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689]
xref: Wikipedia:Segmentation_(biology)
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0035283
name: central nervous system segmentation
namespace: biological_process
def: "Division of the central nervous system into a series of semi-repetitive parts or segments." [GOC:bf]
is_a: GO:0035282 ! segmentation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0035284
name: brain segmentation
namespace: biological_process
def: "Division of the brain into a series of semi-repetitive parts or segments." [GOC:bf]
is_a: GO:0035282 ! segmentation
relationship: part_of GO:0007420 ! brain development
relationship: part_of GO:0035283 ! central nervous system segmentation

[Term]
id: GO:0035285
name: appendage segmentation
namespace: biological_process
def: "Division of an appendage, an organ or part that is attached to the main body of an organism, into a series of semi-repetitive parts or segments. Most arthropod appendages, such as the legs and antennae, are visibly segmented." [PMID:10357895]
is_a: GO:0035282 ! segmentation
relationship: part_of GO:0035107 ! appendage morphogenesis

[Term]
id: GO:0035286
name: leg segmentation
namespace: biological_process
def: "Division of a leg into a series of semi-repetitive parts or segments. Most arthropod appendages are visibly segmented; the Drosophila leg for example has nine segments, each separated from the next by a flexible joint." [PMID:10357895]
is_a: GO:0035285 ! appendage segmentation
relationship: part_of GO:0035110 ! leg morphogenesis

[Term]
id: GO:0035287
name: head segmentation
namespace: biological_process
def: "Partitioning the head anlage into a fixed number of segmental units. The number of segments composing the insect head has long been a subject of debate, but it is generally agreed that there are 6 or 7 segments. From anterior to posterior the head segments are the procephalic segments (labral, (ocular), antennal and intercalary) and the gnathal segments (mandibular, maxillary and labial)." [PMID:10477305, PMID:7915837]
comment: See also the fly_anatomy.ontology term 'head segment ; FBbt:00000006' and its children.
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0007350 ! blastoderm segmentation

[Term]
id: GO:0035288
name: anterior head segmentation
namespace: biological_process
def: "Partitioning the head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments." [PMID:15382136]
comment: See also the fly_anatomy.ontology term 'procephalic segment ; FBbt:00000007' and its children.
synonym: "procephalic segmentation" RELATED []
is_a: GO:0035287 ! head segmentation

[Term]
id: GO:0035289
name: posterior head segmentation
namespace: biological_process
def: "Partitioning the posterior region of the head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains." [PMID:15382136]
comment: See also the fly_anatomy.ontology term 'gnathal segment ; FBbt:00000011' and its children.
synonym: "gnathal segmentation" RELATED []
is_a: GO:0035287 ! head segmentation

[Term]
id: GO:0035290
name: trunk segmentation
namespace: biological_process
def: "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402]
is_a: GO:0035282 ! segmentation
relationship: part_of GO:0007350 ! blastoderm segmentation

[Term]
id: GO:0035291
name: specification of segmental identity, intercalary segment
namespace: biological_process
def: "The specification of the characteristic structures of the intercalary segment of the anterior head, following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437, PMID:10477305]
comment: See also the fly_anatomy.ontology term 'intercalary segment ; FBbt:00000010'.
is_a: GO:0007380 ! specification of segmental identity, head
relationship: part_of GO:0035288 ! anterior head segmentation

[Term]
id: GO:0035292
name: specification of segmental identity, trunk
namespace: biological_process
def: "The specification of the characteristic structures of trunk segments, following establishment of segment boundaries. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [PMID:1360402]
is_a: GO:0007379 ! segment specification
relationship: part_of GO:0035290 ! trunk segmentation

[Term]
id: GO:0035293
name: chitin-based larval cuticle pattern formation
namespace: biological_process
def: "The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
is_a: GO:0035017 ! cuticle pattern formation
relationship: part_of GO:0008363 ! larval chitin-based cuticle development

[Term]
id: GO:0035294
name: determination of wing disc primordium
namespace: biological_process
def: "Allocation of embryonic cells to the wing disc founder populations, groups of cells that are committed to contribute to the formation of a wing imaginal disc." [ISBN:0879694238]
is_a: GO:0007445 ! determination of imaginal disc primordium
is_a: GO:0035220 ! wing disc development

[Term]
id: GO:0035295
name: tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0035296
name: regulation of tube diameter
namespace: biological_process
def: "Ensuring that a tube is the correct width." [GOC:bf]
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0035150 ! regulation of tube size

[Term]
id: GO:0035297
name: regulation of Malpighian tubule diameter
namespace: biological_process
def: "Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells." [PMID:9286684]
is_a: GO:0035296 ! regulation of tube diameter
relationship: part_of GO:0035298 ! regulation of Malpighian tubule size

[Term]
id: GO:0035298
name: regulation of Malpighian tubule size
namespace: biological_process
def: "Ensuring that a Malpighian tubule is the correct length and diameter." [GOC:bf]
is_a: GO:0035150 ! regulation of tube size
relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis

[Term]
id: GO:0035299
name: inositol pentakisphosphate 2-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate." [EC:2.7.1.158]
synonym: "ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.158]
synonym: "Gsl1p" RELATED [EC:2.7.1.158]
synonym: "inositol 1,3,4,5,6-pentakisphosphate 2-kinase activity" EXACT [EC:2.7.1.158]
synonym: "inositol polyphosphate kinase activity" EXACT [EC:2.7.1.158]
synonym: "inositol-pentakisphosphate 2-kinase activity" EXACT [EC:2.7.1.158]
synonym: "Ins(1,3,4,5,6)P5 2-kinase activity" EXACT [EC:2.7.1.158]
synonym: "IP5 2-kinase activity" EXACT [EC:2.7.1.158]
synonym: "Ipk1p" RELATED [EC:2.7.1.158]
xref: EC:2.7.1.158
xref: MetaCyc:2.7.1.158-RXN
is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0035300
name: inositol-1,3,4-trisphosphate 5/6-kinase activity
namespace: molecular_function
def: "Catalysis of the reactions: ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate and ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate." [EC:2.7.1.159, PMID:9126335]
synonym: "ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.159]
synonym: "inositol 1,3,4-trisphosphate 5-kinase activity" NARROW []
synonym: "inositol 1,3,4-trisphosphate 6-kinase activity" NARROW []
synonym: "inositol trisphosphate 5/6-kinase activity" EXACT [EC:2.7.1.159]
synonym: "Ins(1,3,4)P3 5/6-kinase activity" EXACT [EC:2.7.1.159]
synonym: "IP56K" RELATED [EC:2.7.1.159]
xref: EC:2.7.1.159
xref: MetaCyc:2.7.1.133-RXN
is_a: GO:0051766 ! inositol trisphosphate kinase activity

[Term]
id: GO:0035301
name: Hedgehog signaling complex
namespace: cellular_component
def: "A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila)." [PMID:10825151, PMID:15057936]
synonym: "Hedgehog signalling complex" EXACT []
synonym: "HSC" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0035302
name: ecdysteroid 25-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:15350618]
comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22,25-trideoxyecdysone (3-beta,5-beta-ketodiol) to 2,22-dideoxyecdysone (3-beta,5-beta-ketotriol).
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0035303
name: regulation of dephosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]
subset: gosubset_prok
is_a: GO:0019220 ! regulation of phosphate metabolic process
relationship: regulates GO:0016311 ! dephosphorylation

[Term]
id: GO:0035304
name: regulation of protein amino acid dephosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]
subset: gosubset_prok
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0035303 ! regulation of dephosphorylation
relationship: regulates GO:0006470 ! protein amino acid dephosphorylation

[Term]
id: GO:0035305
name: negative regulation of dephosphorylation
namespace: biological_process
def: "Any process the stops, prevents or reduces the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]
subset: gosubset_prok
synonym: "down regulation of dephosphorylation" EXACT []
synonym: "down-regulation of dephosphorylation" EXACT []
synonym: "downregulation of dephosphorylation" EXACT []
synonym: "inhibition of dephosphorylation" NARROW []
is_a: GO:0035303 ! regulation of dephosphorylation
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
relationship: negatively_regulates GO:0016311 ! dephosphorylation

[Term]
id: GO:0035306
name: positive regulation of dephosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf]
subset: gosubset_prok
synonym: "activation of dephosphorylation" NARROW []
synonym: "stimulation of dephosphorylation" NARROW []
synonym: "up regulation of dephosphorylation" EXACT []
synonym: "up-regulation of dephosphorylation" EXACT []
synonym: "upregulation of dephosphorylation" EXACT []
is_a: GO:0035303 ! regulation of dephosphorylation
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
relationship: positively_regulates GO:0016311 ! dephosphorylation

[Term]
id: GO:0035307
name: positive regulation of protein amino acid dephosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]
subset: gosubset_prok
synonym: "activation of protein amino acid dephosphorylation" NARROW []
synonym: "stimulation of protein amino acid dephosphorylation" NARROW []
synonym: "up regulation of protein amino acid dephosphorylation" EXACT []
synonym: "up-regulation of protein amino acid dephosphorylation" EXACT []
synonym: "upregulation of protein amino acid dephosphorylation" EXACT []
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0035304 ! regulation of protein amino acid dephosphorylation
is_a: GO:0035306 ! positive regulation of dephosphorylation
relationship: positively_regulates GO:0006470 ! protein amino acid dephosphorylation

[Term]
id: GO:0035308
name: negative regulation of protein amino acid dephosphorylation
namespace: biological_process
def: "Any process the stops, prevents or reduces the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf]
subset: gosubset_prok
synonym: "down regulation of protein amino acid dephosphorylation" EXACT []
synonym: "down-regulation of protein amino acid dephosphorylation" EXACT []
synonym: "downregulation of protein amino acid dephosphorylation" EXACT []
synonym: "inhibition of protein amino acid dephosphorylation" NARROW []
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0035304 ! regulation of protein amino acid dephosphorylation
is_a: GO:0035305 ! negative regulation of dephosphorylation
relationship: negatively_regulates GO:0006470 ! protein amino acid dephosphorylation

[Term]
id: GO:0035309
name: wing and notum subfield formation
namespace: biological_process
def: "The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures." [PMID:10860999]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0035220 ! wing disc development

[Term]
id: GO:0035310
name: notum cell fate specification
namespace: biological_process
def: "Process by which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment." [PMID:10860999]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0035309 ! wing and notum subfield formation

[Term]
id: GO:0035311
name: wing cell fate specification
namespace: biological_process
def: "Process by which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment." [PMID:10860999]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0035309 ! wing and notum subfield formation

[Term]
id: GO:0035312
name: 5'-3' exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule." [ISBN:0198547684]
is_a: GO:0008409 ! 5'-3' exonuclease activity
is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0035313
name: wound healing, spreading of epidermal cells
namespace: biological_process
def: "The migration of an epithelial cell along or through a wound gap to reestablish a continuous epithelium." [GOC:bf, PMID:15269788]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0035314
name: scab formation
namespace: biological_process
def: "Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection." [GOC:bf, PMID:15269788]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0035315
name: hair cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a hair cell." [GOC:bf]
is_a: GO:0009913 ! epidermal cell differentiation

[Term]
id: GO:0035316
name: non-sensory hair organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis." [GOC:mtg_sensu, PMID:11064425]
comment: See also the fly_anatomy.ontology term 'trichome ; FBbt:00004979'.
synonym: "non-sensory hair organization and biogenesis" RELATED [GOC:mah]
synonym: "trichome organisation" BROAD []
synonym: "trichome organization and biogenesis" BROAD []
is_a: GO:0030030 ! cell projection organization
relationship: part_of GO:0035315 ! hair cell differentiation

[Term]
id: GO:0035317
name: imaginal disc-derived wing hair organization
namespace: biological_process
def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853]
comment: See also the fly_anatomy.ontology term 'wing hair ; FBbt:00004340'.
synonym: "imaginal disc-derived wing hair organization and biogenesis" RELATED [GOC:mah]
synonym: "wing hair organisation" EXACT [GOC:curators]
synonym: "wing hair organization and biogenesis" RELATED [GOC:mah]
synonym: "wing trichome organization and biogenesis" EXACT []
is_a: GO:0035316 ! non-sensory hair organization
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0035318
name: imaginal disc-derived wing hair outgrowth
namespace: biological_process
def: "Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair." [GOC:mtg_sensu, PMID:11064425, PMID:8947551]
synonym: "wing hair outgrowth" EXACT []
synonym: "wing prehair outgrowth" RELATED []
is_a: GO:0048858 ! cell projection morphogenesis
relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization

[Term]
id: GO:0035319
name: imaginal disc-derived wing hair elongation
namespace: biological_process
def: "Growth of a prehair in the approximately 10 hour period following its emergence from an epidermal cell in an imaginal disc-derived wing. Prehair elongation is guided and/or driven by the polymerization of actin filaments and the orderly crosslinking of filaments into bundles." [GOC:mtg_sensu, PMID:11832234]
synonym: "wing hair elongation" EXACT []
synonym: "wing prehair extension" RELATED []
is_a: GO:0048858 ! cell projection morphogenesis
relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization

[Term]
id: GO:0035320
name: imaginal disc-derived wing hair site selection
namespace: biological_process
def: "Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally." [GOC:mtg_transport, ISBN:0815340729, PMID:8947551]
synonym: "prehair localization" RELATED []
synonym: "wing hair site selection" EXACT []
is_a: GO:0022606 ! establishment of proximal/distal cell polarity
relationship: part_of GO:0001737 ! establishment of imaginal disc-derived wing hair orientation

[Term]
id: GO:0035321
name: maintenance of imaginal disc-derived wing hair orientation
namespace: biological_process
def: "Ensuring that hairs in the imaginal disc-derived wing continue to point distally during development, following the initial establishment of wing hair polarity." [GOC:mtg_sensu, PMID:15501220]
synonym: "maintenance of wing hair orientation" EXACT []
is_a: GO:0009954 ! proximal/distal pattern formation
relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization

[Term]
id: GO:0035322
name: mesenchymal cell migration involved in limb bud formation
namespace: biological_process
def: "The orderly movement of a mesenchymal cell from one site to another that will contribute to the formation of a limb bud." [GOC:dgh]
is_a: GO:0090131 ! mesenchyme migration
relationship: part_of GO:0060174 ! limb bud formation

[Term]
id: GO:0035323
name: male germline ring canal
namespace: cellular_component
def: "An intercellular bridge that connects the germline cells of a male cyst." [PMID:9635420]
synonym: "spermatocyte ring canal" NARROW []
synonym: "testicular ring canal" NARROW []
is_a: GO:0045172 ! germline ring canal

[Term]
id: GO:0035324
name: female germline ring canal
namespace: cellular_component
def: "An intercellular bridge that connects the germline cells of a female cyst." [PMID:9635420]
synonym: "nurse cell ring canal" NARROW []
synonym: "ovarian ring canal" NARROW []
is_a: GO:0045172 ! germline ring canal

[Term]
id: GO:0035325
name: Toll-like receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response." [PMID:19076341]
synonym: "TLR binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0035326
name: enhancer binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an enhancer, a cis-acting sequence that increases the utilization of some eukaryotic promoters, and can function in either orientation and in any location (upstream or downstream) relative to the promoter." [GOC:sart]
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0035327
name: transcriptionally active chromatin
namespace: cellular_component
def: "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed." [GOC:sart, PMID:17965872]
is_a: GO:0000785 ! chromatin

[Term]
id: GO:0035328
name: transcriptionally silent chromatin
namespace: cellular_component
def: "The ordered and organized complex of DNA and protein that forms regions of the chromosome that are not being actively transcribed." [GOC:sart, PMID:17965872]
synonym: "transcriptionally inactive chromatin" EXACT []
is_a: GO:0000785 ! chromatin

[Term]
id: GO:0035329
name: hippo signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1." [PMID:17318211, PMID:18328423]
synonym: "Salvador-Warts-Hippo signaling pathway" NARROW []
synonym: "SWH pathway" NARROW []
is_a: GO:0023034 ! intracellular signaling pathway

[Term]
id: GO:0035330
name: regulation of hippo signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hippo signaling." [GOC:ref]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0035329 ! hippo signaling pathway

[Term]
id: GO:0035331
name: negative regulation of hippo signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hippo signaling." [GOC:ref]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0035330 ! regulation of hippo signaling pathway
relationship: negatively_regulates GO:0035329 ! hippo signaling pathway

[Term]
id: GO:0035332
name: positive regulation of hippo signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hippo signaling." [GOC:ref]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0035330 ! regulation of hippo signaling pathway
relationship: positively_regulates GO:0035329 ! hippo signaling pathway

[Term]
id: GO:0035333
name: Notch receptor processing, ligand-dependent
namespace: biological_process
def: "The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD)." [PMID:12651094]
synonym: "Notch S2 cleavage" NARROW []
synonym: "Notch S3 cleavage" NARROW []
is_a: GO:0051605 ! protein maturation by peptide bond cleavage
relationship: part_of GO:0007220 ! Notch receptor processing

[Term]
id: GO:0035334
name: Notch receptor processing, ligand-independent
namespace: biological_process
def: "The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface." [PMID:12651094]
synonym: "Notch S1 cleavage" NARROW []
is_a: GO:0051605 ! protein maturation by peptide bond cleavage
relationship: part_of GO:0007220 ! Notch receptor processing

[Term]
id: GO:0040001
name: establishment of mitotic spindle localization
namespace: biological_process
alt_id: GO:0018986
alt_id: GO:0030605
alt_id: GO:0030606
alt_id: GO:0030608
alt_id: GO:0030610
def: "The cell cycle process whereby the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai]
synonym: "mitotic spindle positioning" EXACT []
synonym: "mitotic spindle positioning and orientation" NARROW []
synonym: "mitotic spindle positioning or orientation" EXACT []
synonym: "spindle positioning during mitosis" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051293 ! establishment of spindle localization
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0040002
name: collagen and cuticulin-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Caenorhabditis elegans." [GOC:mtg_sensu]
synonym: "collagen and cuticulin-based cuticle anabolism" EXACT []
synonym: "collagen and cuticulin-based cuticle biosynthetic process" EXACT []
synonym: "collagen and cuticulin-based cuticle formation" EXACT []
synonym: "collagen and cuticulin-based cuticle synthesis" EXACT []
is_a: GO:0007592 ! protein-based cuticle development

[Term]
id: GO:0040003
name: chitin-based cuticle development
namespace: biological_process
def: "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]
synonym: "chitin-based cuticle anabolism" EXACT []
synonym: "chitin-based cuticle biosynthetic process" EXACT []
synonym: "chitin-based cuticle formation" EXACT []
synonym: "chitin-based cuticle synthesis" EXACT []
is_a: GO:0042335 ! cuticle development

[Term]
id: GO:0040004
name: collagen and cuticulin-based cuticle attachment to epithelium
namespace: biological_process
def: "Attaching of a collagen and cuticulin-based cuticle to the epithelium underlying it. An example of this process is found in Caenorhabditis elegans." [GOC:ems, GOC:mtg_sensu]
synonym: "cuticular attachment to epithelium" BROAD []
is_a: GO:0040006 ! protein-based cuticle attachment to epithelium
relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle

[Term]
id: GO:0040005
name: chitin-based cuticle attachment to epithelium
namespace: biological_process
def: "Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]
synonym: "cuticular attachment to epithelium" BROAD []
is_a: GO:0040006 ! protein-based cuticle attachment to epithelium
relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle

[Term]
id: GO:0040006
name: protein-based cuticle attachment to epithelium
namespace: biological_process
def: "Attaching of a protein-based cuticle to the epithelium underlying it." [GOC:jl, GOC:mtg_sensu]
synonym: "cuticular attachment to epithelium" BROAD []
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0018988 ! molting cycle, protein-based cuticle

[Term]
id: GO:0040007
name: growth
namespace: biological_process
def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]
comment: See also the biological process term 'cell growth ; GO:0016049'.
subset: goslim_generic
subset: goslim_pir
subset: goslim_plant
subset: gosubset_prok
synonym: "growth pattern" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0040008
name: regulation of growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]
subset: gosubset_prok
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0040007 ! growth

[Term]
id: GO:0040009
name: regulation of growth rate
namespace: biological_process
def: "Any process that modulates the rate of growth of all or part of an organism." [GOC:mah]
comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation.
is_a: GO:0040008 ! regulation of growth

[Term]
id: GO:0040010
name: positive regulation of growth rate
namespace: biological_process
def: "Any process that increases the rate of growth of all or part of an organism." [GOC:mah]
comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation.
synonym: "activation of growth rate" NARROW []
synonym: "stimulation of growth rate" NARROW []
synonym: "up regulation of growth rate" EXACT []
synonym: "up-regulation of growth rate" EXACT []
synonym: "upregulation of growth rate" EXACT []
is_a: GO:0040009 ! regulation of growth rate
is_a: GO:0045927 ! positive regulation of growth

[Term]
id: GO:0040011
name: locomotion
namespace: biological_process
def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0040012
name: regulation of locomotion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0040011 ! locomotion

[Term]
id: GO:0040013
name: negative regulation of locomotion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators]
synonym: "down regulation of locomotion" EXACT []
synonym: "down-regulation of locomotion" EXACT []
synonym: "downregulation of locomotion" EXACT []
synonym: "inhibition of locomotion" NARROW []
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0040011 ! locomotion

[Term]
id: GO:0040014
name: regulation of multicellular organism growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb]
synonym: "regulation of body growth" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of body size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0040008 ! regulation of growth
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0035264 ! multicellular organism growth

[Term]
id: GO:0040015
name: negative regulation of multicellular organism growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb]
synonym: "negative regulation of body growth" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of body size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0040014 ! regulation of multicellular organism growth
is_a: GO:0045926 ! negative regulation of growth
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0035264 ! multicellular organism growth

[Term]
id: GO:0040016
name: embryonic cleavage
namespace: biological_process
def: "The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300]
is_a: GO:0051301 ! cell division
relationship: part_of GO:0009790 ! embryonic development

[Term]
id: GO:0040017
name: positive regulation of locomotion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators]
synonym: "activation of locomotion" NARROW []
synonym: "stimulation of locomotion" NARROW []
synonym: "up regulation of locomotion" EXACT []
synonym: "up-regulation of locomotion" EXACT []
synonym: "upregulation of locomotion" EXACT []
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0040011 ! locomotion

[Term]
id: GO:0040018
name: positive regulation of multicellular organism growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "positive regulation of body growth" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of body size" EXACT [GOC:dph, GOC:tb]
is_a: GO:0040014 ! regulation of multicellular organism growth
is_a: GO:0045927 ! positive regulation of growth
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0035264 ! multicellular organism growth

[Term]
id: GO:0040019
name: positive regulation of embryonic development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryonic development." [GOC:go_curators]
synonym: "activation of embryonic development" NARROW []
synonym: "stimulation of embryonic development" NARROW []
synonym: "up regulation of embryonic development" EXACT []
synonym: "up-regulation of embryonic development" EXACT []
synonym: "upregulation of embryonic development" EXACT []
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0009790 ! embryonic development

[Term]
id: GO:0040020
name: regulation of meiosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meiosis, the process by which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0051445 ! regulation of meiotic cell cycle
relationship: regulates GO:0007126 ! meiosis

[Term]
id: GO:0040021
name: hermaphrodite germ-line sex determination
namespace: biological_process
alt_id: GO:0042005
def: "The determination of sex and sexual phenotype in the germ line of a hermaphrodite." [GOC:ems]
is_a: GO:0018992 ! germ-line sex determination

[Term]
id: GO:0040022
name: feminization of hermaphroditic germ-line
namespace: biological_process
def: "The determination of female sex and sexual phenotype in the germ-line of the hermaphrodite." [GOC:ems]
is_a: GO:0040021 ! hermaphrodite germ-line sex determination

[Term]
id: GO:0040023
name: establishment of nucleus localization
namespace: biological_process
def: "The directed movement of the nucleus to a specific location within a cell." [GOC:ai]
synonym: "establishment of cell nucleus localization" EXACT []
synonym: "establishment of localization of nucleus" EXACT []
synonym: "establishment of position of nucleus" EXACT []
synonym: "nuclear positioning" EXACT []
synonym: "nucleus positioning" EXACT []
synonym: "positioning of nucleus" EXACT []
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization
relationship: part_of GO:0051647 ! nucleus localization

[Term]
id: GO:0040024
name: dauer larval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:ems, ISBN:087969307X]
is_a: GO:0002119 ! nematode larval development

[Term]
id: GO:0040025
name: vulval development
namespace: biological_process
def: "The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv, ISBN:087969307X]
is_a: GO:0048569 ! post-embryonic organ development
relationship: part_of GO:0002119 ! nematode larval development

[Term]
id: GO:0040026
name: positive regulation of vulval development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv]
synonym: "activation of vulval development" RELATED []
synonym: "stimulation of vulval development" RELATED []
synonym: "up regulation of vulval development" RELATED []
synonym: "up-regulation of vulval development" RELATED []
synonym: "upregulation of vulval development" RELATED []
is_a: GO:0040028 ! regulation of vulval development
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0040025 ! vulval development

[Term]
id: GO:0040027
name: negative regulation of vulval development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv]
synonym: "down regulation of vulval development" EXACT []
synonym: "down-regulation of vulval development" EXACT []
synonym: "downregulation of vulval development" EXACT []
synonym: "inhibition of vulval development" NARROW []
synonym: "negative regulation of vulval development" EXACT []
is_a: GO:0040028 ! regulation of vulval development
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0040025 ! vulval development

[Term]
id: GO:0040028
name: regulation of vulval development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:kmv, GOC:ma]
is_a: GO:0048580 ! regulation of post-embryonic development
relationship: regulates GO:0040025 ! vulval development

[Term]
id: GO:0040029
name: regulation of gene expression, epigenetic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence." [PMID:10521337, PMID:11498582]
subset: goslim_generic
subset: goslim_plant
subset: gosubset_prok
is_a: GO:0010468 ! regulation of gene expression

[Term]
id: GO:0040030
name: regulation of molecular function, epigenetic
namespace: biological_process
def: "Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:ems, GOC:tb, PMID:10611975, PMID:11050225, PMID:11447696, PMID:11685242, PMID:11782551]
synonym: "regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb]
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0040031
name: snRNA modification
namespace: biological_process
def: "The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA." [GOC:jl]
is_a: GO:0009451 ! RNA modification
is_a: GO:0016073 ! snRNA metabolic process

[Term]
id: GO:0040032
name: post-embryonic body morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the post-embryonic soma are generated and organized. Morphogenesis pertains to the creation of form." [GOC:ems, ISBN:0140512888]
comment: Note that this term was 'body morphogenesis (sensu Nematoda)'.
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0010171 ! body morphogenesis

[Term]
id: GO:0040033
name: negative regulation of translation, ncRNA-mediated
namespace: biological_process
def: "Any process, mediated by small non-coding RNAs, that stops, prevents or reduces the rate that mRNAs are effectively translated into protein." [GOC:dph, GOC:ems, GOC:tb]
synonym: "down regulation of mRNA translation, ncRNA-mediated" EXACT []
synonym: "down-regulation of mRNA translation, ncRNA-mediated" EXACT []
synonym: "downregulation of mRNA translation, ncRNA-mediated" EXACT []
synonym: "inhibition of mRNA translation, ncRNA-mediated" NARROW []
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0045974 ! regulation of translation, ncRNA-mediated

[Term]
id: GO:0040034
name: regulation of development, heterochronic
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the progression an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition at a consistent predetermined time point during its development." [PMID:9442909]
synonym: "developmental timing" RELATED []
synonym: "heterochronic regulation of development" EXACT []
synonym: "temporal regulation of development" EXACT []
is_a: GO:0050793 ! regulation of developmental process

[Term]
id: GO:0040035
name: hermaphrodite genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures." [GOC:ems, ISBN:0140512888]
is_a: GO:0048806 ! genitalia development

[Term]
id: GO:0040036
name: regulation of fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "regulation of FGF receptor signaling pathway" EXACT []
synonym: "regulation of FGF receptor signalling pathway" EXACT []
synonym: "regulation of FGFR signaling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway

[Term]
id: GO:0040037
name: negative regulation of fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "down regulation of fibroblast growth factor receptor signaling pathway" EXACT []
synonym: "down-regulation of fibroblast growth factor receptor signaling pathway" EXACT []
synonym: "downregulation of fibroblast growth factor receptor signaling pathway" EXACT []
synonym: "inhibition of fibroblast growth factor receptor signaling pathway" NARROW []
synonym: "negative regulation of FGF receptor signaling pathway" EXACT []
synonym: "negative regulation of FGF receptor signalling pathway" EXACT []
synonym: "negative regulation of FGFR signaling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway
relationship: negatively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway

[Term]
id: GO:0040038
name: polar body extrusion after meiotic divisions
namespace: biological_process
def: "The cell cycle process whereby two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes." [GOC:ems, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0033206 ! cytokinesis after meiosis
relationship: part_of GO:0007143 ! female meiosis

[Term]
id: GO:0040039
name: inductive cell migration
namespace: biological_process
def: "Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans." [ISBN:087969307X, ISBN:0879694882]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0040040
name: thermosensory behavior
namespace: biological_process
def: "Behavior that is dependent upon the sensation of temperature." [GOC:ems]
synonym: "behavioral response to temperature stimulus" EXACT []
synonym: "behavioural response to temperature stimulus" EXACT []
synonym: "thermosensory behaviour" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0009266 ! response to temperature stimulus

[Term]
id: GO:0042000
name: translocation of peptides or proteins into host
namespace: biological_process
def: "The directed movement of peptides or proteins produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "transport of peptides or proteins into host" EXACT []
is_a: GO:0044417 ! translocation of molecules into host
is_a: GO:0051808 ! translocation of peptides or proteins into other organism during symbiotic interaction

[Term]
id: GO:0042001
name: hermaphrodite somatic sex determination
namespace: biological_process
alt_id: GO:0042002
def: "The determination of sex and sexual phenotypes in a hermaphroditic organism's soma. An example of this is found in Caenorhabditis elegans." [GOC:ems]
is_a: GO:0018993 ! somatic sex determination

[Term]
id: GO:0042003
name: masculinization of hermaphrodite soma
namespace: biological_process
def: "Promotion of male sex and sexual phenotypes in the hermaphroditic nematode soma. An example of this is found in Caenorhabditis elegans." [GOC:ems]
is_a: GO:0042001 ! hermaphrodite somatic sex determination

[Term]
id: GO:0042004
name: feminization of hermaphrodite soma
namespace: biological_process
def: "Promotion of female sex and sexual phenotypes in the hermaphroditic soma. An example of this is found in Caenorhabditis elegans." [GOC:ems]
is_a: GO:0042001 ! hermaphrodite somatic sex determination

[Term]
id: GO:0042006
name: masculinization of hermaphroditic germ-line
namespace: biological_process
def: "The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite. An example of this is found in Caenorhabditis elegans." [GOC:ems]
is_a: GO:0040021 ! hermaphrodite germ-line sex determination

[Term]
id: GO:0042007
name: interleukin-18 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-18." [GOC:jl]
synonym: "IL-18 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042008
name: interleukin-18 receptor activity
namespace: molecular_function
def: "Combining with interleukin-18 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-18 receptor activity" EXACT [GOC:mah]
synonym: "IL-18R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0042007 ! interleukin-18 binding

[Term]
id: GO:0042009
name: interleukin-15 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-15." [GOC:jl]
synonym: "IL-15 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042010
name: interleukin-15 receptor activity
namespace: molecular_function
def: "Combining with interleukin-15 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-15 receptor activity" EXACT [GOC:mah]
synonym: "IL-15R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0042009 ! interleukin-15 binding

[Term]
id: GO:0042011
name: interleukin-16 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-16." [GOC:jl]
synonym: "IL-16 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042012
name: interleukin-16 receptor activity
namespace: molecular_function
def: "Combining with interleukin-16 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-16 receptor activity" EXACT [GOC:mah]
synonym: "IL-16R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0042011 ! interleukin-16 binding

[Term]
id: GO:0042013
name: interleukin-19 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-19." [GOC:jl]
synonym: "IL-19 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042014
name: interleukin-19 receptor activity
namespace: molecular_function
def: "Combining with interleukin-19 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-19 receptor activity" EXACT [GOC:mah]
synonym: "IL-19R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0042013 ! interleukin-19 binding

[Term]
id: GO:0042015
name: interleukin-20 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-20." [GOC:jl]
synonym: "IL-20 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042016
name: interleukin-20 receptor activity
namespace: molecular_function
def: "Combining with interleukin-20 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-20 receptor activity" EXACT [GOC:mah]
synonym: "IL-20R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0042015 ! interleukin-20 binding

[Term]
id: GO:0042017
name: interleukin-22 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-22." [GOC:jl]
synonym: "IL-22 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042018
name: interleukin-22 receptor activity
namespace: molecular_function
def: "Combining with interleukin-22 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-22 receptor activity" EXACT [GOC:mah]
synonym: "IL-22R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0042017 ! interleukin-22 binding

[Term]
id: GO:0042019
name: interleukin-23 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-23." [GOC:jl]
synonym: "IL-23 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042020
name: interleukin-23 receptor activity
namespace: molecular_function
def: "Combining with interleukin-23 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-23 receptor activity" EXACT [GOC:mah]
synonym: "IL-23R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0042019 ! interleukin-23 binding

[Term]
id: GO:0042021
name: granulocyte macrophage colony-stimulating factor complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the granulocyte macrophage colony-stimulating factor complex." [GOC:ai]
synonym: "GM-CSF complex binding" EXACT []
synonym: "GMC-SF complex binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0042022
name: interleukin-12 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-12; comprises an alpha and a beta subunit." [GOC:mah, PMID:10971505]
synonym: "IL-12 receptor complex" EXACT [GOC:add]
synonym: "IL12RB1-IL12RB2 complex" NARROW [CORUM:2026]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0042023
name: DNA endoreduplication
namespace: biological_process
def: "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. For example, occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl]
comment: Note that this term is only to be used in situations were this process occurs normally. Not to be used to describe mutant or diseased states.
subset: gosubset_prok
synonym: "DNA endoreplication" EXACT []
synonym: "DNA re-duplication" EXACT []
is_a: GO:0006261 ! DNA-dependent DNA replication
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0042024
name: DNA endoreduplication initiation
namespace: biological_process
def: "The reinitiation of DNA replication within a single cell cycle." [GOC:jl]
subset: gosubset_prok
synonym: "DNA re-replication initiation" EXACT []
is_a: GO:0006270 ! DNA replication initiation

[Term]
id: GO:0042025
name: host cell nucleus
namespace: cellular_component
alt_id: GO:0033649
def: "A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0033648 ! host intracellular membrane-bounded organelle

[Term]
id: GO:0042026
name: protein refolding
namespace: biological_process
def: "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]
subset: gosubset_prok
synonym: "heat shock protein activity" RELATED []
is_a: GO:0006457 ! protein folding

[Term]
id: GO:0042027
name: cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: peptidylproline (omega=180) = peptidylproline (omega=0)." [EC:5.2.1.8]
comment: This term was made obsolete because it is contains gene product specific characteristics.
is_obsolete: true
consider: GO:0003755

[Term]
id: GO:0042029
name: fibrolase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen." [EC:3.4.24.72, PMID:7725320]
comment: This term was made obsolete because it represents a gene product.
synonym: "Agkistrodon contortrix contortrix metalloproteinase activity" NARROW [EC:3.4.24.72]
synonym: "Agkistrodon contortrix contortrix venom metalloproteinase activity" NARROW [EC:3.4.24.72]
synonym: "fibrinolytic proteinase activity" EXACT [EC:3.4.24.72]
xref: EC:3.4.24.72
xref: MetaCyc:3.4.24.72-RXN
is_obsolete: true
replaced_by: GO:0004222

[Term]
id: GO:0042030
name: ATPase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of ATP to ADP and orthophosphate." [GOC:jl]
synonym: "adenosinetriphosphatase inhibitor" EXACT []
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0060590 ! ATPase regulator activity

[Term]
id: GO:0042031
name: angiotensin-converting enzyme inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of angiotensin-converting enzyme, thereby preventing the synthesis of angiotensin II from its precursor, angiotensin I." [GOC:jl]
comment: This term was made obsolete because it represents a regulator of a non-existent molecular function term.
synonym: "ACE inhibitor" EXACT []
synonym: "peptidyl dipeptidase A inhibitor" EXACT []
xref: Wikipedia:ACE_inhibitor
is_obsolete: true
replaced_by: GO:0060422

[Term]
id: GO:0042033
name: chemokine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "chemokine anabolism" EXACT []
synonym: "chemokine biosynthesis" EXACT []
synonym: "chemokine formation" EXACT []
synonym: "chemokine synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
is_a: GO:0050755 ! chemokine metabolic process
relationship: part_of GO:0032602 ! chemokine production

[Term]
id: GO:0042034
name: peptidyl-lysine esterification
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptidyl-L-lysine methyl ester." [RESID:AA0318]
subset: gosubset_prok
xref: RESID:AA0318
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018350 ! protein amino acid esterification

[Term]
id: GO:0042035
name: regulation of cytokine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators]
synonym: "regulation of cytokine anabolism" EXACT []
synonym: "regulation of cytokine biosynthesis" EXACT []
synonym: "regulation of cytokine formation" EXACT []
synonym: "regulation of cytokine synthesis" EXACT []
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
relationship: regulates GO:0042089 ! cytokine biosynthetic process

[Term]
id: GO:0042036
name: negative regulation of cytokine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators]
synonym: "down regulation of cytokine biosynthetic process" EXACT []
synonym: "down-regulation of cytokine biosynthetic process" EXACT []
synonym: "downregulation of cytokine biosynthetic process" EXACT []
synonym: "inhibition of cytokine biosynthetic process" NARROW []
synonym: "negative regulation of cytokine anabolism" EXACT []
synonym: "negative regulation of cytokine biosynthesis" EXACT []
synonym: "negative regulation of cytokine formation" EXACT []
synonym: "negative regulation of cytokine synthesis" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: negatively_regulates GO:0042089 ! cytokine biosynthetic process

[Term]
id: GO:0042037
name: peptidyl-histidine methylation, to form pros-methylhistidine
namespace: biological_process
alt_id: GO:0042260
def: "The methylation of peptidyl-L-histidine to form peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073]
subset: gosubset_prok
synonym: "peptidyl-histidine pros-methylation" EXACT []
xref: RESID:AA0073
is_a: GO:0018021 ! peptidyl-histidine methylation

[Term]
id: GO:0042038
name: peptidyl-histidine methylation, to form tele-methylhistidine
namespace: biological_process
alt_id: GO:0042261
def: "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine)." [RESID:AA0317]
subset: gosubset_prok
synonym: "peptidyl-histidine tele-methylation" EXACT []
xref: RESID:AA0317
is_a: GO:0018021 ! peptidyl-histidine methylation

[Term]
id: GO:0042039
name: vanadium incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of vanadium a metallo-sulfur cluster such as VFe(7-8)S(n)." [PMID:11053414]
subset: gosubset_prok
synonym: "vanadium incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster

[Term]
id: GO:0042040
name: metal incorporation into metallo-molybdopterin complex
namespace: biological_process
def: "The incorporation of a metal into a metallo-molybdopterin complex." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0042042
name: tungsten incorporation into tungsten-molybdopterin complex
namespace: biological_process
def: "The incorporation of tungsten into a tungsten-molybdopterin complex." [GOC:ai]
subset: gosubset_prok
is_a: GO:0042040 ! metal incorporation into metallo-molybdopterin complex

[Term]
id: GO:0042043
name: neurexin binding
namespace: molecular_function
alt_id: GO:0019963
def: "Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals." [http://cancerweb.ncl.ac.uk/]
synonym: "neuroligin" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0042044
name: fluid transport
namespace: biological_process
def: "The directed movement of substances that are in liquid form in normal living conditions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0042045
name: epithelial fluid transport
namespace: biological_process
def: "The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830]
is_a: GO:0042044 ! fluid transport

[Term]
id: GO:0042046
name: W-molybdopterin cofactor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [ISSN:09498257]
subset: gosubset_prok
synonym: "Moco metabolic process" BROAD []
synonym: "Moco metabolism" BROAD []
synonym: "W-molybdopterin cofactor metabolism" EXACT []
is_a: GO:0043545 ! molybdopterin cofactor metabolic process

[Term]
id: GO:0042047
name: W-molybdopterin cofactor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [ISSN:09498257]
subset: gosubset_prok
synonym: "Moco biosynthesis" BROAD []
synonym: "Moco biosynthetic process" BROAD []
synonym: "W-molybdopterin cofactor anabolism" EXACT []
synonym: "W-molybdopterin cofactor biosynthesis" EXACT []
synonym: "W-molybdopterin cofactor formation" EXACT []
synonym: "W-molybdopterin cofactor synthesis" EXACT []
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0032324 ! molybdopterin cofactor biosynthetic process
is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process

[Term]
id: GO:0042048
name: olfactory behavior
namespace: biological_process
def: "The actions or reactions of an organism in response to an odor." [GOC:jic]
synonym: "behavioral response to scent" EXACT []
synonym: "behavioral response to smell" EXACT []
synonym: "behavioural response to odour" EXACT []
synonym: "behavioural response to scent" EXACT []
synonym: "behavioural response to smell" EXACT []
synonym: "olfactory behaviour" EXACT []
is_a: GO:0007635 ! chemosensory behavior

[Term]
id: GO:0042049
name: cellular acyl-CoA homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of acyl-CoA within a cell or between a cell and its external environment." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "cell acyl-CoA homeostasis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0055082 ! cellular chemical homeostasis

[Term]
id: GO:0042051
name: compound eye photoreceptor development
namespace: biological_process
def: "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]
synonym: "adult eye photoreceptor development" NARROW []
is_a: GO:0042462 ! eye photoreceptor cell development
relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0042052
name: rhabdomere development
namespace: biological_process
def: "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]
synonym: "rhabdomere organization" EXACT [GOC:mah]
is_a: GO:0006996 ! organelle organization
relationship: part_of GO:0042051 ! compound eye photoreceptor development

[Term]
id: GO:0042053
name: regulation of dopamine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators]
synonym: "regulation of dopamine metabolism" EXACT []
is_a: GO:0042069 ! regulation of catecholamine metabolic process
relationship: regulates GO:0042417 ! dopamine metabolic process

[Term]
id: GO:0042054
name: histone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group (CH3-) to a histone." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "histone methylase activity" EXACT [GOC:mah]
is_a: GO:0008276 ! protein methyltransferase activity

[Term]
id: GO:0042056
name: chemoattractant activity
namespace: molecular_function
def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
synonym: "attractant" BROAD []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0042057
name: transforming growth factor beta receptor anchoring activity
namespace: molecular_function
def: "OBSOLETE. Binds to transforming growth factor beta receptor and anchors it to a particular subcellular location." [GOC:ai]
comment: This term was made obsolete because it represents a combination of process and function information.
synonym: "TGF-beta receptor anchoring activity" EXACT []
synonym: "TGFbeta receptor anchoring activity" EXACT []
synonym: "transforming growth factor beta receptor anchor activity" EXACT []
is_obsolete: true
replaced_by: GO:0005160
replaced_by: GO:0008104

[Term]
id: GO:0042058
name: regulation of epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "regulation of EGF receptor signaling pathway" EXACT []
synonym: "regulation of EGF receptor signalling pathway" EXACT []
synonym: "regulation of EGFR signaling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0007173 ! epidermal growth factor receptor signaling pathway

[Term]
id: GO:0042059
name: negative regulation of epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "down regulation of epidermal growth factor receptor signaling pathway" EXACT []
synonym: "down-regulation of epidermal growth factor receptor signaling pathway" EXACT []
synonym: "downregulation of epidermal growth factor receptor signaling pathway" EXACT []
synonym: "inhibition of epidermal growth factor receptor signaling pathway" NARROW []
synonym: "negative regulation of EGF receptor signaling pathway" EXACT []
synonym: "negative regulation of EGF receptor signalling pathway" EXACT []
synonym: "negative regulation of EGFR signaling pathway" EXACT []
xref: Reactome:182971 "EGFR downregulation"
xref: Reactome:448818 "EGFR downregulation"
xref: Reactome:469934 "EGFR downregulation"
xref: Reactome:487637 "EGFR downregulation"
xref: Reactome:507596 "EGFR downregulation"
xref: Reactome:517565 "EGFR downregulation"
xref: Reactome:526431 "EGFR downregulation"
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway
relationship: negatively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway

[Term]
id: GO:0042060
name: wound healing
namespace: biological_process
def: "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]
xref: Wikipedia:Wound_healing
is_a: GO:0009611 ! response to wounding

[Term]
id: GO:0042062
name: long-term strengthening of neuromuscular junction
namespace: biological_process
def: "Any process that results in an increase in the efficacy of transmission at a neuromuscular synapse." [GO_REF:0000021, GOC:mtg_15jun06_ch]
comment: This term was added by GO_REF:0000021.
is_a: GO:0050806 ! positive regulation of synaptic transmission
relationship: part_of GO:0008582 ! regulation of synaptic growth at neuromuscular junction

[Term]
id: GO:0042063
name: gliogenesis
namespace: biological_process
def: "The process by which glial cells are generated. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jic]
synonym: "glial cell generation" EXACT systematic_synonym []
is_a: GO:0022008 ! neurogenesis

[Term]
id: GO:0042064
name: cell adhesion receptor regulator activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0005102
consider: GO:0030155

[Term]
id: GO:0042065
name: glial cell growth
namespace: biological_process
def: "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:dph, GOC:isa_complete, GOC:jic]
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0042063 ! gliogenesis

[Term]
id: GO:0042066
name: perineurial glial growth
namespace: biological_process
def: "Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons." [GOC:mah, PMID:11517334, PMID:18176560]
is_a: GO:0042065 ! glial cell growth

[Term]
id: GO:0042067
name: establishment of ommatidial planar polarity
namespace: biological_process
def: "The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]
synonym: "establishment of ommatidial polarity" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0001736 ! establishment of planar polarity
is_a: GO:0007163 ! establishment or maintenance of cell polarity
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0042068
name: regulation of pteridine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of pteridine metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
relationship: regulates GO:0019889 ! pteridine metabolic process

[Term]
id: GO:0042069
name: regulation of catecholamine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of catecholamine metabolism" EXACT []
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0042070
name: maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis specification
namespace: biological_process
alt_id: GO:0048127
def: "Maintenance of the oocyte nucleus in a particular position within the cell during the establishment and maintenance of the axes of the oocyte. An example of this process is found In Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb]
synonym: "maintenance of oocyte nucleus localization during oocyte axis determination" BROAD [GOC:dph, GOC:tb]
synonym: "maintenance of oocyte nucleus location involved in oocyte dorsal-ventral axis specification" EXACT [GOC:mah]
synonym: "maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb]
synonym: "maintenance of oocyte nucleus location involved in oocyte dorsoventral axis specification" EXACT [GOC:mah]
synonym: "maintenance of oocyte nucleus position during oocyte axis determination" BROAD []
synonym: "oocyte axis determination, maintenance of oocyte nucleus localization" BROAD []
synonym: "oocyte axis determination, maintenance of oocyte nucleus position" BROAD []
synonym: "oocyte axis determination, oocyte nucleus anchoring" BROAD []
synonym: "oocyte nucleus anchoring during oocyte axis determination" BROAD []
is_a: GO:0051658 ! maintenance of nucleus location
relationship: part_of GO:0051663 ! oocyte nucleus localization involved in oocyte dorsal/ventral axis specification

[Term]
id: GO:0042071
name: leucokinin receptor activity
namespace: molecular_function
def: "Combining with a leucokinin, any of several octapeptide hormones found in insects, to initiate a change in cell activity." [GOC:mah, PMID:2716741]
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0042072
name: cell adhesion receptor inhibitor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0005102
consider: GO:0007162

[Term]
id: GO:0042073
name: intraflagellar transport
namespace: biological_process
def: "The bidirectional movement of large protein complexes along microtubules within a cilium or flagellum, mediated by motor proteins." [GOC:kmv, PMID:17981739, PMID:18180368]
xref: Wikipedia:Intraflagellar_transport
is_a: GO:0010970 ! microtubule-based transport
relationship: part_of GO:0043064 ! flagellum organization

[Term]
id: GO:0042074
name: cell migration involved in gastrulation
namespace: biological_process
def: "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression)." [GOC:jl, http://www.cellmigration.org/, ISBN:0878932437]
is_a: GO:0001667 ! ameboidal cell migration
relationship: part_of GO:0007369 ! gastrulation

[Term]
id: GO:0042075
name: nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide
namespace: biological_process
def: "The incorporation of nickel into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." [RESID:AA0310]
subset: gosubset_prok
synonym: "nickel incorporation into nickel-iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide" EXACT []
xref: RESID:AA0310
is_a: GO:0016226 ! iron-sulfur cluster assembly
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster

[Term]
id: GO:0042076
name: protein amino acid phosphate-linked glycosylation
namespace: biological_process
def: "The glycosylation of peptidyl-amino acids through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues." [PMID:7499424]
subset: gosubset_prok
synonym: "phosphoglycosylation" EXACT []
is_a: GO:0006486 ! protein amino acid glycosylation

[Term]
id: GO:0042077
name: protein amino acid phosphate-linked glycosylation via serine
namespace: biological_process
def: "The glycosylation of peptidyl-serine through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues." [GOC:mah]
subset: gosubset_prok
is_a: GO:0042076 ! protein amino acid phosphate-linked glycosylation

[Term]
id: GO:0042078
name: germ-line stem cell division
namespace: biological_process
alt_id: GO:0048131
def: "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jic, PMID:2279698]
synonym: "germ-line stem cell renewal" EXACT []
is_a: GO:0008356 ! asymmetric cell division
is_a: GO:0017145 ! stem cell division
relationship: part_of GO:0007281 ! germ cell development

[Term]
id: GO:0042079
name: GPI/GSI anchor metabolic process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it is a composite term that represents two individual processes.
is_obsolete: true
consider: GO:0006505
consider: GO:0042081

[Term]
id: GO:0042080
name: GPI/GSI anchor biosynthetic process
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
comment: This term was made obsolete because it is a composite term that represents two individual processes.
synonym: "GPI/GSI anchor anabolism" EXACT []
synonym: "GPI/GSI anchor biosynthesis" EXACT []
synonym: "GPI/GSI anchor formation" EXACT []
synonym: "GPI/GSI anchor synthesis" EXACT []
is_obsolete: true
consider: GO:0006506
consider: GO:0042082

[Term]
id: GO:0042081
name: GSI anchor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane." [GOC:go_curators]
subset: gosubset_prok
synonym: "GPI/GSI anchor metabolic process" BROAD []
synonym: "GPI/GSI anchor metabolism" BROAD []
synonym: "GSI anchor metabolism" EXACT []
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0042082
name: GSI anchor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid moiety is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage." [GOC:go_curators, GOC:jsg]
subset: gosubset_prok
synonym: "GPI/GSI anchor biosynthesis" BROAD []
synonym: "GPI/GSI anchor biosynthetic process" BROAD []
synonym: "GSI anchor anabolism" EXACT []
synonym: "GSI anchor biosynthesis" EXACT []
synonym: "GSI anchor formation" EXACT []
synonym: "GSI anchor synthesis" EXACT []
is_a: GO:0006497 ! protein amino acid lipidation
is_a: GO:0006688 ! glycosphingolipid biosynthetic process
is_a: GO:0042081 ! GSI anchor metabolic process

[Term]
id: GO:0042083
name: 5,10-methylenetetrahydrofolate-dependent methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0042084
name: 5-methyltetrahydrofolate-dependent methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0042085
name: 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0042086
name: 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0042088
name: T-helper 1 type immune response
namespace: biological_process
def: "An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "Th1 immune response" EXACT []
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0042089
name: cytokine biosynthetic process
namespace: biological_process
alt_id: GO:0042032
def: "The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0198599471]
synonym: "cytokine anabolism" EXACT []
synonym: "cytokine biosynthesis" EXACT []
synonym: "cytokine formation" EXACT []
synonym: "cytokine synthesis" EXACT []
synonym: "induction of cytokines" NARROW []
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
is_a: GO:0042107 ! cytokine metabolic process
relationship: part_of GO:0001816 ! cytokine production

[Term]
id: GO:0042090
name: interleukin-12 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators]
synonym: "IL-12 biosynthesis" EXACT []
synonym: "IL-12 biosynthetic process" EXACT []
synonym: "interleukin-12 anabolism" EXACT []
synonym: "interleukin-12 biosynthesis" EXACT []
synonym: "interleukin-12 formation" EXACT []
synonym: "interleukin-12 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032615 ! interleukin-12 production

[Term]
id: GO:0042091
name: interleukin-10 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators]
synonym: "IL-10 biosynthesis" EXACT []
synonym: "IL-10 biosynthetic process" EXACT []
synonym: "interleukin-10 anabolism" EXACT []
synonym: "interleukin-10 biosynthesis" EXACT []
synonym: "interleukin-10 formation" EXACT []
synonym: "interleukin-10 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032613 ! interleukin-10 production

[Term]
id: GO:0042092
name: T-helper 2 type immune response
namespace: biological_process
def: "An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is typically orchestrated by the production of particular cytokines by T-helper 2 cells, most notably IL-4, IL-5, IL-10, and IL-13, resulting in enhanced production of certain antibody isotypes and other effects." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "Th2 immune response" EXACT []
is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

[Term]
id: GO:0042093
name: T-helper cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized thymocyte acquires specialized features of a T-helper cell." [GOC:ebc]
is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation during immune response

[Term]
id: GO:0042094
name: interleukin-2 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators]
synonym: "IL-2 biosynthesis" EXACT []
synonym: "IL-2 biosynthetic process" EXACT []
synonym: "interleukin-2 anabolism" EXACT []
synonym: "interleukin-2 biosynthesis" EXACT []
synonym: "interleukin-2 formation" EXACT []
synonym: "interleukin-2 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032623 ! interleukin-2 production

[Term]
id: GO:0042095
name: interferon-gamma biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators]
synonym: "IFN-gamma biosynthesis" EXACT []
synonym: "IFN-gamma biosynthetic process" EXACT []
synonym: "interferon type II biosynthesis" EXACT []
synonym: "interferon type II biosynthetic process" EXACT []
synonym: "interferon-gamma anabolism" EXACT []
synonym: "interferon-gamma biosynthesis" EXACT []
synonym: "interferon-gamma formation" EXACT []
synonym: "interferon-gamma synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032609 ! interferon-gamma production

[Term]
id: GO:0042096
name: alpha-beta T cell receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes a receptor type, and not an activity.
is_obsolete: true
consider: GO:0032394
consider: GO:0032395
consider: GO:0042605

[Term]
id: GO:0042097
name: interleukin-4 biosynthetic process
namespace: biological_process
alt_id: GO:0042224
def: "The chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators]
synonym: "IL-4 biosynthesis" EXACT []
synonym: "IL-4 biosynthetic process" EXACT []
synonym: "interleukin-4 anabolism" EXACT []
synonym: "interleukin-4 biosynthesis" EXACT []
synonym: "interleukin-4 formation" EXACT []
synonym: "interleukin-4 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032633 ! interleukin-4 production

[Term]
id: GO:0042098
name: T cell proliferation
namespace: biological_process
alt_id: GO:0042111
def: "The expansion of a T cell population by cell division. Follows T cell activation." [GOC:jl]
synonym: "T lymphocyte proliferation" EXACT []
synonym: "T-cell proliferation" EXACT []
synonym: "T-lymphocyte proliferation" EXACT []
is_a: GO:0042110 ! T cell activation
is_a: GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0042099
name: gamma-delta T cell receptor activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl]
comment: This term was made obsolete because it describes a receptor type, and not an activity.
is_obsolete: true
consider: GO:0032394
consider: GO:0032395
consider: GO:0042605

[Term]
id: GO:0042100
name: B cell proliferation
namespace: biological_process
alt_id: GO:0042114
def: "The expansion of a B cell population by cell division. Follows B cell activation." [GOC:jl]
synonym: "B lymphocyte proliferation" EXACT []
synonym: "B-cell proliferation" EXACT []
synonym: "B-lymphocyte proliferation" EXACT []
is_a: GO:0042113 ! B cell activation
is_a: GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0042101
name: T cell receptor complex
namespace: cellular_component
def: "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." [GOC:mah, ISBN:0781735149 "Fundamental Immunology"]
synonym: "T lymphocyte receptor complex" EXACT []
synonym: "T-cell receptor complex" EXACT []
synonym: "T-lymphocyte receptor complex" EXACT []
synonym: "TCR" RELATED []
xref: Wikipedia:T_cell_receptor
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0042102
name: positive regulation of T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of T cell proliferation." [GOC:ai]
synonym: "activation of T cell proliferation" NARROW []
synonym: "positive regulation of T lymphocyte proliferation" EXACT []
synonym: "positive regulation of T-lymphocyte proliferation" EXACT []
synonym: "stimulation of T cell proliferation" NARROW []
synonym: "up regulation of T cell proliferation" EXACT []
synonym: "up-regulation of T cell proliferation" EXACT []
synonym: "upregulation of T cell proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0050671 ! positive regulation of lymphocyte proliferation
is_a: GO:0050870 ! positive regulation of T cell activation
relationship: positively_regulates GO:0042098 ! T cell proliferation

[Term]
id: GO:0042103
name: positive regulation of T cell homeostatic proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of resting T cell proliferation." [GOC:jl]
synonym: "activation of T cell homeostatic proliferation" NARROW []
synonym: "positive regulation of resting T cell proliferation" EXACT []
synonym: "positive regulation of T lymphocyte homeostatic proliferation" EXACT []
synonym: "positive regulation of T-cell homeostatic proliferation" EXACT []
synonym: "positive regulation of T-lymphocyte homeostatic proliferation" EXACT []
synonym: "stimulation of T cell homeostatic proliferation" NARROW []
synonym: "up regulation of T cell homeostatic proliferation" EXACT []
synonym: "up-regulation of T cell homeostatic proliferation" EXACT []
synonym: "upregulation of T cell homeostatic proliferation" EXACT []
is_a: GO:0042102 ! positive regulation of T cell proliferation
is_a: GO:0046013 ! regulation of T cell homeostatic proliferation
relationship: positively_regulates GO:0001777 ! T cell homeostatic proliferation

[Term]
id: GO:0042104
name: positive regulation of activated T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of activated T cell proliferation." [GOC:jl]
synonym: "activation of activated T cell proliferation" NARROW []
synonym: "positive regulation of activated T lymphocyte proliferation" EXACT []
synonym: "positive regulation of activated T-cell proliferation" EXACT []
synonym: "positive regulation of activated T-lymphocyte proliferation" EXACT []
synonym: "stimulation of activated T cell proliferation" NARROW []
synonym: "up regulation of activated T cell proliferation" EXACT []
synonym: "up-regulation of activated T cell proliferation" EXACT []
synonym: "upregulation of activated T cell proliferation" EXACT []
is_a: GO:0042102 ! positive regulation of T cell proliferation
is_a: GO:0046006 ! regulation of activated T cell proliferation
relationship: positively_regulates GO:0050798 ! activated T cell proliferation

[Term]
id: GO:0042105
name: alpha-beta T cell receptor complex
namespace: cellular_component
def: "A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein." [GOC:mah, ISBN:0781735149 "Fundamental Immunology"]
synonym: "alpha-beta T lymphocyte receptor complex" EXACT []
synonym: "alpha-beta T-cell receptor complex" EXACT []
synonym: "alpha-beta T-lymphocyte receptor complex" EXACT []
synonym: "alpha-beta TCR complex" EXACT []
is_a: GO:0042101 ! T cell receptor complex

[Term]
id: GO:0042106
name: gamma-delta T cell receptor complex
namespace: cellular_component
def: "A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein." [GOC:mah, ISBN:0781735149 "Fundamental Immunology"]
synonym: "gamma-delta T lymphocyte receptor complex" EXACT []
synonym: "gamma-delta T-cell receptor complex" EXACT []
synonym: "gamma-delta T-lymphocyte receptor complex" EXACT []
synonym: "gamma-delta TCR complex" EXACT []
is_a: GO:0042101 ! T cell receptor complex

[Term]
id: GO:0042107
name: cytokine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GO_REF:0000022, GOC:bf, GOC:go_curators, GOC:mtg_15nov05, ISBN:0198599471]
comment: This term was improved by GO_REF:0000022. It was moved.
synonym: "cytokine metabolism" EXACT []
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0042108
name: positive regulation of cytokine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators]
synonym: "activation of cytokine biosynthetic process" NARROW []
synonym: "positive regulation of cytokine anabolism" EXACT []
synonym: "positive regulation of cytokine biosynthesis" EXACT []
synonym: "positive regulation of cytokine formation" EXACT []
synonym: "positive regulation of cytokine synthesis" EXACT []
synonym: "stimulation of cytokine biosynthetic process" NARROW []
synonym: "up regulation of cytokine biosynthetic process" EXACT []
synonym: "up-regulation of cytokine biosynthetic process" EXACT []
synonym: "upregulation of cytokine biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: positively_regulates GO:0042089 ! cytokine biosynthetic process

[Term]
id: GO:0042109
name: lymphotoxin A biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl]
synonym: "LTA biosynthesis" BROAD []
synonym: "LTA biosynthetic process" BROAD []
synonym: "lymphotoxin A anabolism" EXACT []
synonym: "lymphotoxin A biosynthesis" EXACT []
synonym: "lymphotoxin A formation" EXACT []
synonym: "lymphotoxin A synthesis" EXACT []
synonym: "lymphotoxin-alpha biosynthesis" EXACT []
synonym: "lymphotoxin-alpha biosynthetic process" EXACT []
synonym: "TNF-B biosynthesis" EXACT []
synonym: "TNF-B biosynthetic process" EXACT []
synonym: "TNF-beta biosynthesis" EXACT []
synonym: "TNF-beta biosynthetic process" EXACT []
synonym: "tumor necrosis factor-beta biosynthesis" EXACT []
synonym: "tumor necrosis factor-beta biosynthetic process" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032641 ! lymphotoxin A production

[Term]
id: GO:0042110
name: T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735140]
synonym: "T lymphocyte activation" EXACT []
synonym: "T-cell activation" EXACT []
synonym: "T-lymphocyte activation" EXACT []
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0042113
name: B cell activation
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735140]
synonym: "B lymphocyte activation" EXACT []
synonym: "B-cell activation" EXACT []
synonym: "B-lymphocyte activation" EXACT []
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0042116
name: macrophage activation
namespace: biological_process
def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology", PMID:14506301]
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0042117
name: monocyte activation
namespace: biological_process
def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0042118
name: endothelial cell activation
namespace: biological_process
def: "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology", PMID:12851652, PMID:14581484]
is_a: GO:0001775 ! cell activation

[Term]
id: GO:0042119
name: neutrophil activation
namespace: biological_process
def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0042120
name: alginic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "alginate metabolic process" EXACT []
synonym: "alginate metabolism" EXACT []
synonym: "alginic acid metabolism" EXACT []
is_a: GO:0010412 ! mannan metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0042121
name: alginic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "alginate biosynthesis" EXACT []
synonym: "alginate biosynthetic process" EXACT []
synonym: "alginic acid anabolism" EXACT []
synonym: "alginic acid biosynthesis" EXACT []
synonym: "alginic acid formation" EXACT []
synonym: "alginic acid synthesis" EXACT []
is_a: GO:0042120 ! alginic acid metabolic process
is_a: GO:0046354 ! mannan biosynthetic process

[Term]
id: GO:0042122
name: alginic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "alginate catabolic process" EXACT []
synonym: "alginate catabolism" EXACT []
synonym: "alginic acid breakdown" EXACT []
synonym: "alginic acid catabolism" EXACT []
synonym: "alginic acid degradation" EXACT []
is_a: GO:0042120 ! alginic acid metabolic process
is_a: GO:0046355 ! mannan catabolic process

[Term]
id: GO:0042123
name: glucanosyltransferase activity
namespace: molecular_function
def: "Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation." [GOC:jl]
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0042124
name: 1,3-beta-glucanosyltransferase activity
namespace: molecular_function
def: "Catalysis of the splitting and linkage of 1,3-beta-glucan molecules, resulting in 1,3-beta-glucan chain elongation." [GOC:jl, PMID:10809732]
is_a: GO:0042123 ! glucanosyltransferase activity

[Term]
id: GO:0042125
name: protein amino acid galactosylation
namespace: biological_process
def: "The addition of a galactose molecule to a protein amino acid." [GOC:jl]
subset: gosubset_prok
is_a: GO:0006486 ! protein amino acid glycosylation

[Term]
id: GO:0042126
name: nitrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid." [GOC:jl]
subset: gosubset_prok
synonym: "nitrate metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0042127
name: regulation of cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl]
subset: gosubset_prok
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0008283 ! cell proliferation

[Term]
id: GO:0042128
name: nitrate assimilation
namespace: biological_process
def: "The uptake, from the environment, of nitrates, inorganic or organic salts and esters of nitric acid and the subsequent reduction of nitrate ion to other, less highly oxidized, inorganic nitrogenous substances." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "assimilatory nitrate reduction" EXACT []
xref: MetaCyc:PWY-381
is_a: GO:0042126 ! nitrate metabolic process

[Term]
id: GO:0042129
name: regulation of T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell proliferation." [GOC:jl]
synonym: "regulation of T lymphocyte proliferation" EXACT []
synonym: "regulation of T-cell proliferation" EXACT []
synonym: "regulation of T-lymphocyte proliferation" EXACT []
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0050863 ! regulation of T cell activation
relationship: regulates GO:0042098 ! T cell proliferation

[Term]
id: GO:0042130
name: negative regulation of T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of T cell proliferation." [GOC:jl]
synonym: "down regulation of T cell proliferation" EXACT []
synonym: "down-regulation of T cell proliferation" EXACT []
synonym: "downregulation of T cell proliferation" EXACT []
synonym: "inhibition of T cell proliferation" NARROW []
synonym: "negative regulation of T lymphocyte proliferation" EXACT []
synonym: "negative regulation of T-cell proliferation" EXACT []
synonym: "negative regulation of T-lymphocyte proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0050672 ! negative regulation of lymphocyte proliferation
is_a: GO:0050868 ! negative regulation of T cell activation
relationship: negatively_regulates GO:0042098 ! T cell proliferation

[Term]
id: GO:0042131
name: thiamin phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of thiamin phosphate." [PMID:197075]
synonym: "thiamine phosphate phosphatase activity" EXACT []
is_a: GO:0003993 ! acid phosphatase activity

[Term]
id: GO:0042132
name: fructose 1,6-bisphosphate 1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.11]
subset: gosubset_prok
synonym: "D-fructose 1,6-diphosphatase activity" EXACT [EC:3.1.3.11]
synonym: "D-fructose-1,6-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.11]
synonym: "D-fructose-1,6-bisphosphate phosphatase activity" EXACT [EC:3.1.3.11]
synonym: "FBPase activity" EXACT [EC:3.1.3.11]
synonym: "fructose 1,6-bisphosphatase activity" EXACT [EC:3.1.3.11]
synonym: "fructose 1,6-bisphosphate phosphatase activity" EXACT [EC:3.1.3.11]
synonym: "fructose 1,6-diphosphatase activity" EXACT [EC:3.1.3.11]
synonym: "fructose 1,6-diphosphate phosphatase activity" EXACT [EC:3.1.3.11]
synonym: "fructose bisphosphate phosphatase activity" EXACT [EC:3.1.3.11]
synonym: "fructose diphosphatase activity" EXACT [EC:3.1.3.11]
synonym: "fructose diphosphate phosphatase activity" EXACT [EC:3.1.3.11]
synonym: "fructose-1,6-bisphosphatase activity" EXACT [EC:3.1.3.11]
synonym: "fructose-bisphosphatase activity" BROAD [EC:3.1.3.00]
synonym: "hexose bisphosphatase activity" EXACT [EC:3.1.3.11]
synonym: "hexose diphosphatase activity" EXACT [EC:3.1.3.11]
synonym: "hexosediphosphatase activity" BROAD [EC:3.1.3.11]
xref: EC:3.1.3.11
xref: MetaCyc:F16BDEPHOS-RXN
xref: Reactome:9272 "fructose 1,6-bisphosphate 1-phosphatase activity"
is_a: GO:0019203 ! carbohydrate phosphatase activity

[Term]
id: GO:0042133
name: neurotransmitter metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: goslim_pir
synonym: "neurotransmitter metabolism" EXACT []
xref: Reactome:374909 "Metabolism of Noradrenaline"
xref: Reactome:442356 "Metabolism of Noradrenaline"
xref: Reactome:464108 "Metabolism of Noradrenaline"
xref: Reactome:482514 "Metabolism of Noradrenaline"
xref: Reactome:502734 "Metabolism of Noradrenaline"
xref: Reactome:540906 "Metabolism of Noradrenaline"
xref: Reactome:590858 "Metabolism of Noradrenaline"
xref: Reactome:602013 "Metabolism of Noradrenaline"
is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0042134
name: rRNA primary transcript binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an unprocessed ribosomal RNA transcript." [GOC:jl]
is_a: GO:0019843 ! rRNA binding

[Term]
id: GO:0042135
name: neurotransmitter catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl, http://cancerweb.ncl.ac.uk/]
synonym: "neurotransmitter breakdown" EXACT []
synonym: "neurotransmitter catabolism" EXACT []
synonym: "neurotransmitter degradation" EXACT []
is_a: GO:0042133 ! neurotransmitter metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0042136
name: neurotransmitter biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl, http://cancerweb.ncl.ac.uk/]
synonym: "neurotransmitter anabolism" EXACT []
synonym: "neurotransmitter biosynthesis" EXACT []
synonym: "neurotransmitter biosynthesis and storage" BROAD []
synonym: "neurotransmitter biosynthetic process and storage" BROAD []
synonym: "neurotransmitter formation" EXACT []
synonym: "neurotransmitter synthesis" EXACT []
xref: Reactome:112311 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:448602 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:469731 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:487442 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:507399 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:517401 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:526276 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:531144 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:536515 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:542233 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:547583 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:552192 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:557777 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:568390 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:581592 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:592488 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:597311 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:598112 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:599659 "Neurotransmitter Clearance In The Synaptic Cleft"
xref: Reactome:602472 "Neurotransmitter Clearance In The Synaptic Cleft"
is_a: GO:0042133 ! neurotransmitter metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0042137
name: sequestering of neurotransmitter
namespace: biological_process
def: "The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system." [GOC:ai]
synonym: "neurotransmitter biosynthesis and storage" RELATED []
synonym: "neurotransmitter biosynthetic process and storage" RELATED []
synonym: "neurotransmitter retention" EXACT []
synonym: "neurotransmitter sequestration" EXACT []
synonym: "neurotransmitter storage" EXACT []
synonym: "retention of neurotransmitter" EXACT []
synonym: "sequestration of neurotransmitter" EXACT []
synonym: "storage of neurotransmitter" EXACT []
is_a: GO:0001505 ! regulation of neurotransmitter levels
is_a: GO:0051235 ! maintenance of location

[Term]
id: GO:0042138
name: meiotic DNA double-strand break formation
namespace: biological_process
def: "The cell cycle process whereby double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination." [GOC:elh, GOC:jl, PMID:11529427]
is_a: GO:0000737 ! DNA catabolic process, endonucleolytic
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0042139
name: early meiotic recombination nodule assembly
namespace: biological_process
def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene." [GOC:jl, PMID:9334324]
is_a: GO:0007146 ! meiotic recombination nodule assembly

[Term]
id: GO:0042140
name: late meiotic recombination nodule assembly
namespace: biological_process
def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over." [GOC:jl, PMID:9334324]
is_a: GO:0007146 ! meiotic recombination nodule assembly

[Term]
id: GO:0042141
name: mating pheromone exporter
namespace: molecular_function
def: "OBSOLETE. Exports diffusible peptide signals that are responsible for binding to other cells and triggering a series of responses to facilitate mating." [GOC:jl]
comment: This term was made obsolete because it is too gene product specific.
is_obsolete: true
consider: GO:0042626
consider: GO:0043190

[Term]
id: GO:0042142
name: heavy metal chelation
namespace: biological_process
def: "OBSOLETE. The strong but reversible binding of a heavy metal ion by a larger molecule such as protein." [GOC:jl, ISBN:0124325653]
comment: This term was made obsolete because it represents a molecular function and not a biological process.
is_obsolete: true
replaced_by: GO:0046911

[Term]
id: GO:0042144
name: vacuole fusion, non-autophagic
namespace: biological_process
alt_id: GO:0042145
def: "The fusion of two vacuole membranes to form a single vacuole." [GOC:jl]
synonym: "homotypic vacuole fusion" EXACT []
synonym: "homotypic vacuole fusion (non-autophagic)" EXACT []
synonym: "homotypic vacuole fusion, non-autophagic" EXACT []
synonym: "vacuole fusion (non-autophagic)" EXACT []
is_a: GO:0006944 ! cellular membrane fusion
is_a: GO:0007033 ! vacuole organization

[Term]
id: GO:0042147
name: retrograde transport, endosome to Golgi
namespace: biological_process
def: "The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]
synonym: "retrograde (endosome to Golgi) transport" EXACT []
is_a: GO:0016197 ! endosome transport

[Term]
id: GO:0042148
name: strand invasion
namespace: biological_process
def: "The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:elh, PMID:10357855]
synonym: "D-loop biosynthesis" RELATED []
synonym: "D-loop formation" RELATED []
synonym: "Rad51-mediated strand invasion" EXACT [GOC:elh]
xref: Reactome:76004 "Strand invasion"
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006310 ! DNA recombination

[Term]
id: GO:0042149
name: cellular response to glucose starvation
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose." [GOC:jl]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0042150
name: plasmid recombination
namespace: biological_process
def: "A process of DNA recombination occurring within a plasmid or between plasmids and other plasmids or DNA molecules." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0042151
name: nematocyst
namespace: cellular_component
def: "An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus." [DOI:10.1139/z02-135, GOC:jl]
synonym: "cnidocyst" EXACT []
xref: Wikipedia:Cnidocyte
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044448 ! cell cortex part

[Term]
id: GO:0042152
name: RNA-mediated DNA recombination
namespace: biological_process
def: "The reverse transcription of an RNA molecule followed by recombination between the resultant cDNA and its homologous chromosomal allele." [GOC:jl, PMID:8380627]
subset: gosubset_prok
is_a: GO:0006310 ! DNA recombination

[Term]
id: GO:0042153
name: RPTP-like protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with proteins with similar structure/function to receptor protein tyrosine phosphatases." [GOC:jl]
synonym: "receptor protein tyrosine phosphatase-like protein binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0042156
name: zinc-mediated transcriptional activator activity
namespace: molecular_function
def: "Initiates or upregulates transcription in the presence of zinc." [GOC:jl]
is_a: GO:0016563 ! transcription activator activity

[Term]
id: GO:0042157
name: lipoprotein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "lipoprotein metabolism" EXACT []
xref: Reactome:174800 "Chylomicron-mediated lipid transport"
xref: Reactome:174824 "Lipoprotein metabolism"
xref: Reactome:194223 "HDL-mediated lipid transport"
xref: Reactome:448615 "HDL-mediated lipid transport"
xref: Reactome:448616 "Lipoprotein metabolism"
xref: Reactome:448810 "Chylomicron-mediated lipid transport"
xref: Reactome:469745 "HDL-mediated lipid transport"
xref: Reactome:469746 "Lipoprotein metabolism"
xref: Reactome:469926 "Chylomicron-mediated lipid transport"
xref: Reactome:487450 "HDL-mediated lipid transport"
xref: Reactome:487451 "Lipoprotein metabolism"
xref: Reactome:487629 "Chylomicron-mediated lipid transport"
xref: Reactome:507407 "HDL-mediated lipid transport"
xref: Reactome:507408 "Lipoprotein metabolism"
xref: Reactome:507588 "Chylomicron-mediated lipid transport"
xref: Reactome:517412 "HDL-mediated lipid transport"
xref: Reactome:517413 "Lipoprotein metabolism"
xref: Reactome:517558 "Chylomicron-mediated lipid transport"
xref: Reactome:526286 "HDL-mediated lipid transport"
xref: Reactome:526287 "Lipoprotein metabolism"
xref: Reactome:531150 "HDL-mediated lipid transport"
xref: Reactome:531151 "Lipoprotein metabolism"
xref: Reactome:536521 "HDL-mediated lipid transport"
xref: Reactome:536522 "Lipoprotein metabolism"
xref: Reactome:542239 "HDL-mediated lipid transport"
xref: Reactome:542240 "Lipoprotein metabolism"
xref: Reactome:547587 "HDL-mediated lipid transport"
xref: Reactome:547588 "Lipoprotein metabolism"
xref: Reactome:552199 "HDL-mediated lipid transport"
xref: Reactome:552200 "Lipoprotein metabolism"
xref: Reactome:557785 "HDL-mediated lipid transport"
xref: Reactome:557786 "Lipoprotein metabolism"
xref: Reactome:568398 "HDL-mediated lipid transport"
xref: Reactome:568399 "Lipoprotein metabolism"
xref: Reactome:581600 "HDL-mediated lipid transport"
xref: Reactome:581601 "Lipoprotein metabolism"
xref: Reactome:585793 "HDL-mediated lipid transport"
xref: Reactome:585794 "Lipoprotein metabolism"
xref: Reactome:592496 "HDL-mediated lipid transport"
xref: Reactome:592497 "Lipoprotein metabolism"
xref: Reactome:595344 "HDL-mediated lipid transport"
xref: Reactome:595345 "Lipoprotein metabolism"
xref: Reactome:597319 "HDL-mediated lipid transport"
xref: Reactome:597320 "Lipoprotein metabolism"
xref: Reactome:602480 "HDL-mediated lipid transport"
xref: Reactome:602481 "Lipoprotein metabolism"
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0042158
name: lipoprotein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "lipoprotein anabolism" EXACT []
synonym: "lipoprotein biosynthesis" EXACT []
synonym: "lipoprotein formation" EXACT []
synonym: "lipoprotein synthesis" EXACT []
xref: Reactome:174587 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]"
xref: Reactome:174741 "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron"
xref: Reactome:174786 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex"
xref: Reactome:431225 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex"
xref: Reactome:431239 "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron"
xref: Reactome:442768 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]"
xref: Reactome:453778 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex"
xref: Reactome:473932 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex"
xref: Reactome:482858 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]"
xref: Reactome:492474 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex"
xref: Reactome:503010 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]"
xref: Reactome:510407 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex"
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
is_a: GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0042159
name: lipoprotein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "lipoprotein breakdown" EXACT []
synonym: "lipoprotein catabolism" EXACT []
synonym: "lipoprotein degradation" EXACT []
xref: Reactome:174739 "chylomicron remnant + apoE => chylomicron remnant:apoE complex"
xref: Reactome:434473 "chylomicron remnant + apoE => chylomicron remnant:apoE complex"
xref: Reactome:456958 "chylomicron remnant + apoE => chylomicron remnant:apoE complex"
xref: Reactome:496006 "chylomicron remnant + apoE => chylomicron remnant:apoE complex"
is_a: GO:0042157 ! lipoprotein metabolic process
is_a: GO:0044265 ! cellular macromolecule catabolic process

[Term]
id: GO:0042160
name: lipoprotein modification
namespace: biological_process
def: "The chemical reactions and pathways resulting in the covalent alteration of one or more amino acid or lipid residues occurring in a lipoprotein, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [GOC:mah]
subset: gosubset_prok
is_a: GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0042161
name: lipoprotein oxidation
namespace: biological_process
def: "The modification of a lipoprotein by oxidation of one or more amino acids or the lipid moiety." [GOC:mah]
subset: gosubset_prok
is_a: GO:0042160 ! lipoprotein modification

[Term]
id: GO:0042162
name: telomeric DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624]
synonym: "telomere binding" EXACT []
synonym: "telomeric repeat binding" EXACT []
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0042163
name: interleukin-12 beta subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the beta subunit of interleukin-12." [GOC:mah]
synonym: "CLMFp40 binding" EXACT []
synonym: "IL-12B binding" EXACT []
synonym: "IL-12p40 binding" EXACT []
synonym: "NKSFp40 binding" EXACT []
is_a: GO:0019972 ! interleukin-12 binding

[Term]
id: GO:0042164
name: interleukin-12 alpha subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the alpha subunit of interleukin-12." [GOC:mah]
synonym: "CLMFp35 binding" EXACT []
synonym: "IL-12A binding" EXACT []
synonym: "IL-12p35 binding" EXACT []
synonym: "NKSFp35 binding" EXACT []
is_a: GO:0019972 ! interleukin-12 binding

[Term]
id: GO:0042165
name: neurotransmitter binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0042166
name: acetylcholine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]
is_a: GO:0042165 ! neurotransmitter binding
is_a: GO:0043176 ! amine binding

[Term]
id: GO:0042167
name: heme catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl]
subset: gosubset_prok
synonym: "haem catabolic process" EXACT []
synonym: "haem catabolism" EXACT []
synonym: "heme breakdown" EXACT []
synonym: "heme catabolism" EXACT []
synonym: "heme degradation" EXACT []
is_a: GO:0006787 ! porphyrin catabolic process
is_a: GO:0042168 ! heme metabolic process
is_a: GO:0046149 ! pigment catabolic process

[Term]
id: GO:0042168
name: heme metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]
subset: gosubset_prok
synonym: "haem metabolic process" EXACT []
synonym: "haem metabolism" EXACT []
synonym: "heme metabolism" EXACT []
is_a: GO:0006778 ! porphyrin metabolic process
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0042169
name: SH2 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class." [GOC:go_curators, Pfam:PF00017]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0042170
name: plastid membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a plastid and form the plastid envelope." [GOC:mah]
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009526 ! plastid envelope

[Term]
id: GO:0042171
name: lysophosphatidic acid acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid." [PMID:16369050]
is_a: GO:0071617 ! lysophospholipid acyltransferase activity

[Term]
id: GO:0042173
name: regulation of sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore formation." [GOC:jl]
subset: gosubset_prok
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0043937 ! regulation of sporulation
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0030435 ! sporulation resulting in formation of a cellular spore

[Term]
id: GO:0042174
name: negative regulation of sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sporulation." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of sporulation" EXACT []
synonym: "down-regulation of sporulation" EXACT []
synonym: "downregulation of sporulation" EXACT []
synonym: "inhibition of sporulation" NARROW []
is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore
is_a: GO:0043939 ! negative regulation of sporulation
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: negatively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore

[Term]
id: GO:0042175
name: nuclear envelope-endoplasmic reticulum network
namespace: cellular_component
def: "The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum." [GOC:jl]
synonym: "NE-ER continuum" EXACT []
synonym: "NE-ER network" EXACT []
synonym: "nuclear envelope-endoplasmic reticulum continuum" EXACT []
synonym: "nuclear envelope-ER network" EXACT []
is_a: GO:0016020 ! membrane
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0012505 ! endomembrane system

[Term]
id: GO:0042176
name: regulation of protein catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]
subset: gosubset_prok
synonym: "regulation of protein breakdown" EXACT []
synonym: "regulation of protein catabolism" EXACT []
synonym: "regulation of protein degradation" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: regulates GO:0030163 ! protein catabolic process

[Term]
id: GO:0042177
name: negative regulation of protein catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl, PMID:10207076]
subset: gosubset_prok
synonym: "down regulation of protein catabolic process" EXACT []
synonym: "down-regulation of protein catabolic process" EXACT []
synonym: "downregulation of protein catabolic process" EXACT []
synonym: "inhibition of protein catabolic process" NARROW []
synonym: "negative regulation of protein breakdown" EXACT []
synonym: "negative regulation of protein catabolism" EXACT []
synonym: "negative regulation of protein degradation" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
relationship: negatively_regulates GO:0030163 ! protein catabolic process

[Term]
id: GO:0042178
name: xenobiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:jl]
subset: gosubset_prok
synonym: "xenobiotic breakdown" EXACT []
synonym: "xenobiotic catabolism" EXACT []
synonym: "xenobiotic degradation" EXACT []
is_a: GO:0006805 ! xenobiotic metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0042179
name: nicotine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684]
subset: gosubset_prok
synonym: "nicotine anabolism" EXACT []
synonym: "nicotine biosynthesis" EXACT []
synonym: "nicotine formation" EXACT []
synonym: "nicotine synthesis" EXACT []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0018933 ! nicotine metabolic process

[Term]
id: GO:0042180
name: cellular ketone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153]
subset: goslim_pir
subset: gosubset_prok
synonym: "ketone metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0042181
name: ketone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators]
subset: gosubset_prok
synonym: "ketone anabolism" EXACT []
synonym: "ketone biosynthesis" EXACT []
synonym: "ketone formation" EXACT []
synonym: "ketone synthesis" EXACT []
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process

[Term]
id: GO:0042182
name: ketone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators]
subset: gosubset_prok
synonym: "ketone breakdown" EXACT []
synonym: "ketone catabolism" EXACT []
synonym: "ketone degradation" EXACT []
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044282 ! small molecule catabolic process

[Term]
id: GO:0042183
name: formate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "formate breakdown" EXACT []
synonym: "formate catabolism" EXACT []
synonym: "formate degradation" EXACT []
synonym: "formic acid catabolic process" EXACT []
synonym: "formic acid catabolism" EXACT []
is_a: GO:0015942 ! formate metabolic process

[Term]
id: GO:0042184
name: xylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:go_curators]
subset: gosubset_prok
synonym: "xylene breakdown" EXACT []
synonym: "xylene catabolism" EXACT []
synonym: "xylene degradation" EXACT []
is_a: GO:0018948 ! xylene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043451 ! alkene catabolic process

[Term]
id: GO:0042185
name: m-xylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon." [GOC:go_curators, GOC:jl]
subset: gosubset_prok
synonym: "m-xylene breakdown" EXACT []
synonym: "m-xylene catabolism" EXACT []
synonym: "m-xylene degradation" EXACT []
synonym: "meta-xylene catabolic process" EXACT []
synonym: "meta-xylene catabolism" EXACT []
xref: MetaCyc:PWY-142
is_a: GO:0018949 ! m-xylene metabolic process
is_a: GO:0042184 ! xylene catabolic process

[Term]
id: GO:0042186
name: o-xylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl]
subset: gosubset_prok
synonym: "o-xylene breakdown" EXACT []
synonym: "o-xylene catabolism" EXACT []
synonym: "o-xylene degradation" EXACT []
synonym: "ortho-xylene catabolic process" EXACT []
synonym: "ortho-xylene catabolism" EXACT []
is_a: GO:0018950 ! o-xylene metabolic process
is_a: GO:0042184 ! xylene catabolic process

[Term]
id: GO:0042187
name: p-xylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon." [GOC:jl]
subset: gosubset_prok
synonym: "p-xylene breakdown" EXACT []
synonym: "p-xylene catabolism" EXACT []
synonym: "p-xylene degradation" EXACT []
synonym: "para-xylene catabolic process" EXACT []
synonym: "para-xylene catabolism" EXACT []
is_a: GO:0018951 ! p-xylene metabolic process
is_a: GO:0042184 ! xylene catabolic process

[Term]
id: GO:0042188
name: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GOC:jl]
subset: gosubset_prok
synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane breakdown" EXACT []
synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolism" EXACT []
synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane degradation" EXACT []
synonym: "DDT catabolic process" EXACT []
synonym: "DDT catabolism" EXACT []
is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process
is_a: GO:0046701 ! insecticide catabolic process

[Term]
id: GO:0042189
name: vanillin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods." [GOC:jl]
subset: gosubset_prok
synonym: "vanillic aldehyde biosynthesis" EXACT []
synonym: "vanillic aldehyde biosynthetic process" EXACT []
synonym: "vanillin anabolism" EXACT []
synonym: "vanillin biosynthesis" EXACT []
synonym: "vanillin formation" EXACT []
synonym: "vanillin synthesis" EXACT []
is_a: GO:0018982 ! vanillin metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process

[Term]
id: GO:0042190
name: vanillin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods." [GOC:jl]
subset: gosubset_prok
synonym: "vanillic aldehyde catabolic process" EXACT []
synonym: "vanillic aldehyde catabolism" EXACT []
synonym: "vanillin breakdown" EXACT []
synonym: "vanillin catabolism" EXACT []
synonym: "vanillin degradation" EXACT []
is_a: GO:0018982 ! vanillin metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0046185 ! aldehyde catabolic process

[Term]
id: GO:0042191
name: methylmercury metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving methylmercury (MeHg+), a highly toxic organometal which can accumulate in tissues, particularly in fish species." [GOC:ai]
subset: gosubset_prok
synonym: "methylmercury metabolism" EXACT []
is_a: GO:0018941 ! organomercury metabolic process

[Term]
id: GO:0042192
name: methylmercury biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methylmercury (MeHg+), a highly toxic organometal." [GOC:ai]
subset: gosubset_prok
synonym: "methylmercury anabolism" EXACT []
synonym: "methylmercury biosynthesis" EXACT []
synonym: "methylmercury formation" EXACT []
synonym: "methylmercury synthesis" EXACT []
is_a: GO:0042191 ! methylmercury metabolic process
is_a: GO:0046414 ! organomercury biosynthetic process

[Term]
id: GO:0042193
name: methylmercury catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylmercury (MeHg+), a highly toxic organometal." [GOC:ai]
subset: gosubset_prok
synonym: "methylmercury breakdown" EXACT []
synonym: "methylmercury catabolism" EXACT []
synonym: "methylmercury degradation" EXACT []
is_a: GO:0042191 ! methylmercury metabolic process
is_a: GO:0046413 ! organomercury catabolic process

[Term]
id: GO:0042194
name: quinate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "quinate anabolism" EXACT []
synonym: "quinate biosynthesis" EXACT []
synonym: "quinate formation" EXACT []
synonym: "quinate synthesis" EXACT []
synonym: "quinic acid biosynthesis" EXACT []
synonym: "quinic acid biosynthetic process" EXACT []
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0019630 ! quinate metabolic process

[Term]
id: GO:0042195
name: aerobic gallate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the presence of oxygen." [GOC:jl]
subset: gosubset_prok
synonym: "aerobic gallate breakdown" EXACT []
synonym: "aerobic gallate catabolism" EXACT []
synonym: "aerobic gallate degradation" EXACT []
synonym: "aerobic gallic acid catabolic process" EXACT []
synonym: "aerobic gallic acid catabolism" EXACT []
is_a: GO:0019396 ! gallate catabolic process

[Term]
id: GO:0042196
name: chlorinated hydrocarbon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it." [GOC:ai]
subset: gosubset_prok
synonym: "chlorinated hydrocarbon metabolism" EXACT []
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process

[Term]
id: GO:0042197
name: halogenated hydrocarbon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it. Halogens include fluorine, chlorine, bromine and iodine." [GOC:ai]
subset: gosubset_prok
synonym: "halogenated hydrocarbon metabolism" EXACT []
xref: Reactome:436264 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide"
xref: Reactome:458674 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide"
xref: Reactome:539647 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide"
xref: Reactome:76475 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide"
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0042198
name: nylon metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids." [SP_KW:KW-0549]
subset: gosubset_prok
synonym: "nylon metabolism" EXACT []
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0042199
name: cyanuric acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives." [http://umbbd.ahc.umn.edu/cya/cya_map.html, UM-BBD_pathwayID:cya]
subset: gosubset_prok
synonym: "cyanuric acid metabolism" EXACT []
is_a: GO:0018965 ! s-triazine compound metabolic process

[Term]
id: GO:0042200
name: cyanuric acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyanuric acid, a potential degradation product of triazine herbicides." [http://umbbd.ahc.umn.edu/cya/cya_map.html, UM-BBD_pathwayID:cya]
subset: gosubset_prok
synonym: "cyanuric acid breakdown" EXACT []
synonym: "cyanuric acid catabolism" EXACT []
synonym: "cyanuric acid degradation" EXACT []
xref: UM-BBD_pathwayID:cya
is_a: GO:0042199 ! cyanuric acid metabolic process
is_a: GO:0042204 ! s-triazine compound catabolic process

[Term]
id: GO:0042201
name: N-cyclopropylmelamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide." [http://umbbd.ahc.umn.edu/cpm/cpm_map.html, UM-BBD_pathwayID:cpm]
subset: gosubset_prok
synonym: "cyromazine metabolic process" EXACT []
synonym: "cyromazine metabolism" EXACT []
synonym: "N-cyclopropylmelamine metabolism" EXACT []
is_a: GO:0018965 ! s-triazine compound metabolic process

[Term]
id: GO:0042202
name: N-cyclopropylmelamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of N-cyclopropylmelamine, a triazine compound commonly used as an insecticide." [http://umbbd.ahc.umn.edu/cpm/cpm_map.html, UM-BBD_pathwayID:cpm]
subset: gosubset_prok
synonym: "cyromazine catabolic process" EXACT []
synonym: "cyromazine catabolism" EXACT []
synonym: "N-cyclopropylmelamine breakdown" EXACT []
synonym: "N-cyclopropylmelamine catabolism" EXACT []
synonym: "N-cyclopropylmelamine degradation" EXACT []
xref: UM-BBD_pathwayID:cpm
is_a: GO:0042201 ! N-cyclopropylmelamine metabolic process
is_a: GO:0042204 ! s-triazine compound catabolic process

[Term]
id: GO:0042203
name: toluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [GOC:go_curators]
subset: gosubset_prok
synonym: "toluene breakdown" EXACT []
synonym: "toluene catabolism" EXACT []
synonym: "toluene degradation" EXACT []
is_a: GO:0018970 ! toluene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043451 ! alkene catabolic process

[Term]
id: GO:0042204
name: s-triazine compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms." [http://umbbd.ahc.umn.edu/tria/tria_map.html, UM-BBD_pathwayID:tria]
subset: gosubset_prok
synonym: "s-triazine compound breakdown" EXACT []
synonym: "s-triazine compound catabolism" EXACT []
synonym: "s-triazine compound degradation" EXACT []
xref: UM-BBD_pathwayID:tria
is_a: GO:0018965 ! s-triazine compound metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0042205
name: chlorinated hydrocarbon catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it." [GOC:ai]
subset: gosubset_prok
synonym: "chlorinated hydrocarbon breakdown" EXACT []
synonym: "chlorinated hydrocarbon catabolism" EXACT []
synonym: "chlorinated hydrocarbon degradation" EXACT []
is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process
is_a: GO:0042206 ! halogenated hydrocarbon catabolic process

[Term]
id: GO:0042206
name: halogenated hydrocarbon catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it." [GOC:ai]
subset: gosubset_prok
synonym: "halogenated hydrocarbon breakdown" EXACT []
synonym: "halogenated hydrocarbon catabolism" EXACT []
synonym: "halogenated hydrocarbon degradation" EXACT []
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042197 ! halogenated hydrocarbon metabolic process

[Term]
id: GO:0042207
name: styrene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GOC:jl]
subset: gosubset_prok
synonym: "styrene breakdown" EXACT []
synonym: "styrene catabolism" EXACT []
synonym: "styrene degradation" EXACT []
xref: UM-BBD_pathwayID:sty
is_a: GO:0018966 ! styrene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043451 ! alkene catabolic process

[Term]
id: GO:0042208
name: propylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining." [GOC:jl]
subset: gosubset_prok
synonym: "propylene breakdown" EXACT []
synonym: "propylene catabolism" EXACT []
synonym: "propylene degradation" EXACT []
xref: UM-BBD_pathwayID:pro
is_a: GO:0018964 ! propylene metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043451 ! alkene catabolic process

[Term]
id: GO:0042209
name: orcinol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants." [GOC:jl]
subset: gosubset_prok
synonym: "orcin catabolic process" EXACT []
synonym: "orcin catabolism" EXACT []
synonym: "orcinol breakdown" EXACT []
synonym: "orcinol catabolism" EXACT []
synonym: "orcinol degradation" EXACT []
xref: UM-BBD_pathwayID:orc
is_a: GO:0018940 ! orcinol metabolic process
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0042203 ! toluene catabolic process

[Term]
id: GO:0042210
name: octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol
namespace: biological_process
def: "The anaerobic chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane into dimethylsilanediol. The former is a tetramer of the latter." [GOC:jl]
subset: gosubset_prok
synonym: "catabolic process of octamethylcyclotetrasiloxane to DMSD" EXACT []
synonym: "catabolism of octamethylcyclotetrasiloxane to DMSD" EXACT []
synonym: "octamethylcyclotetrasiloxane breakdown to dimethylsilanediol" EXACT []
synonym: "octamethylcyclotetrasiloxane degradation to dimethylsilanediol" EXACT []
xref: UM-BBD_pathwayID:osi
is_a: GO:0018947 ! anaerobic organosilicon metabolic process
is_a: GO:0046454 ! dimethylsilanediol metabolic process
is_a: GO:0046517 ! octamethylcyclotetrasiloxane catabolic process

[Term]
id: GO:0042211
name: dimethylsilanediol catabolic process
namespace: biological_process
def: "The aerobic chemical reactions and pathways resulting in the breakdown of dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products." [GOC:jl]
subset: gosubset_prok
synonym: "catabolic process of DMSD" EXACT []
synonym: "catabolism of DMSD" EXACT []
synonym: "degradation of dimethylsilanediol" EXACT []
synonym: "dimethylsilanediol breakdown" EXACT []
synonym: "dimethylsilanediol catabolism" EXACT []
synonym: "dimethylsilanediol degradation" EXACT []
is_a: GO:0018946 ! aerobic organosilicon metabolic process
is_a: GO:0046454 ! dimethylsilanediol metabolic process
is_a: GO:0046455 ! organosilicon catabolic process

[Term]
id: GO:0042212
name: cresol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [http://umbbd.ahc.umn.edu/mcr/mcr_map.html, UM-BBD_pathwayID:mcr]
subset: gosubset_prok
synonym: "cresol metabolism" EXACT []
synonym: "hydroxytoluene metabolic process" EXACT []
synonym: "hydroxytoluene metabolism" EXACT []
is_a: GO:0018958 ! phenol metabolic process
is_a: GO:0018970 ! toluene metabolic process

[Term]
id: GO:0042213
name: m-cresol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of m-cresol (3-hydroxytoluene), the meta-isoform of cresol." [GOC:jl]
subset: gosubset_prok
synonym: "3-hydroxytoluene catabolic process" EXACT []
synonym: "3-hydroxytoluene catabolism" EXACT []
synonym: "m-cresol breakdown" EXACT []
synonym: "m-cresol catabolism" EXACT []
synonym: "m-cresol degradation" EXACT []
synonym: "meta-cresol catabolic process" EXACT []
synonym: "meta-cresol catabolism" EXACT []
xref: MetaCyc:M-CRESOL-DEGRADATION-PWY
xref: UM-BBD_pathwayID:mcr
is_a: GO:0018925 ! m-cresol metabolic process
is_a: GO:0046199 ! cresol catabolic process

[Term]
id: GO:0042214
name: terpene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "terpene metabolism" EXACT []
is_a: GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0042215
name: anaerobic phenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "anaerobic carbolic acid metabolic process" EXACT []
synonym: "anaerobic carbolic acid metabolism" EXACT []
synonym: "anaerobic hydroxybenzene metabolic process" EXACT []
synonym: "anaerobic hydroxybenzene metabolism" EXACT []
synonym: "anaerobic phenol metabolism" EXACT []
xref: UM-BBD_pathwayID:phe
is_a: GO:0018958 ! phenol metabolic process

[Term]
id: GO:0042216
name: phenanthrene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon." [GOC:jl]
subset: gosubset_prok
synonym: "phenanthrene breakdown" EXACT []
synonym: "phenanthrene catabolism" EXACT []
synonym: "phenanthrene degradation" EXACT []
xref: UM-BBD_pathwayID:phe
is_a: GO:0018955 ! phenanthrene metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043451 ! alkene catabolic process

[Term]
id: GO:0042217
name: 1-aminocyclopropane-1-carboxylate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [GOC:go_curators]
subset: gosubset_prok
synonym: "1-aminocyclopropane-1-carboxylate breakdown" EXACT []
synonym: "1-aminocyclopropane-1-carboxylate catabolism" EXACT []
synonym: "1-aminocyclopropane-1-carboxylate degradation" EXACT []
is_a: GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042219 ! cellular amino acid derivative catabolic process

[Term]
id: GO:0042218
name: 1-aminocyclopropane-1-carboxylate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [GOC:go_curators]
subset: gosubset_prok
synonym: "1-aminocyclopropane-1-carboxylate anabolism" EXACT []
synonym: "1-aminocyclopropane-1-carboxylate biosynthesis" EXACT []
synonym: "1-aminocyclopropane-1-carboxylate formation" EXACT []
synonym: "1-aminocyclopropane-1-carboxylate synthesis" EXACT []
is_a: GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process
relationship: part_of GO:0009693 ! ethylene biosynthetic process

[Term]
id: GO:0042219
name: cellular amino acid derivative catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]
subset: gosubset_prok
synonym: "cellular amino acid derivative breakdown" EXACT []
synonym: "cellular amino acid derivative catabolism" EXACT []
synonym: "cellular amino acid derivative degradation" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044282 ! small molecule catabolic process

[Term]
id: GO:0042220
name: response to cocaine
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [ChEBI:27958, GOC:ef, GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0014073 ! response to tropane
is_a: GO:0043279 ! response to alkaloid

[Term]
id: GO:0042221
name: response to chemical stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]
subset: goslim_candida
subset: goslim_yeast
subset: gosubset_prok
synonym: "response to chemical substance" EXACT []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0042222
name: interleukin-1 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-1, an interleukin produced mainly by activated macrophages. It is involved in the inflammatory response, and is identified as an endogenous pyrogen." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "IL-1 biosynthesis" EXACT []
synonym: "IL-1 biosynthetic process" EXACT []
synonym: "interleukin-1 anabolism" EXACT []
synonym: "interleukin-1 biosynthesis" EXACT []
synonym: "interleukin-1 formation" EXACT []
synonym: "interleukin-1 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032612 ! interleukin-1 production

[Term]
id: GO:0042223
name: interleukin-3 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators]
synonym: "IL-3 biosynthesis" EXACT []
synonym: "IL-3 biosynthetic process" EXACT []
synonym: "interleukin-3 anabolism" EXACT []
synonym: "interleukin-3 biosynthesis" EXACT []
synonym: "interleukin-3 formation" EXACT []
synonym: "interleukin-3 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032632 ! interleukin-3 production

[Term]
id: GO:0042225
name: interleukin-5 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators]
synonym: "IL-5 biosynthesis" EXACT []
synonym: "IL-5 biosynthetic process" EXACT []
synonym: "interleukin-5 anabolism" EXACT []
synonym: "interleukin-5 biosynthesis" EXACT []
synonym: "interleukin-5 formation" EXACT []
synonym: "interleukin-5 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032634 ! interleukin-5 production

[Term]
id: GO:0042226
name: interleukin-6 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators]
synonym: "IL-6 biosynthesis" EXACT []
synonym: "IL-6 biosynthetic process" EXACT []
synonym: "interleukin-6 anabolism" EXACT []
synonym: "interleukin-6 biosynthesis" EXACT []
synonym: "interleukin-6 formation" EXACT []
synonym: "interleukin-6 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032635 ! interleukin-6 production

[Term]
id: GO:0042227
name: interleukin-7 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators]
synonym: "IL-7 biosynthesis" EXACT []
synonym: "IL-7 biosynthetic process" EXACT []
synonym: "interleukin-7 anabolism" EXACT []
synonym: "interleukin-7 biosynthesis" EXACT []
synonym: "interleukin-7 formation" EXACT []
synonym: "interleukin-7 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032636 ! interleukin-7 production

[Term]
id: GO:0042228
name: interleukin-8 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators]
synonym: "IL-8 biosynthesis" EXACT []
synonym: "IL-8 biosynthetic process" EXACT []
synonym: "interleukin-8 anabolism" EXACT []
synonym: "interleukin-8 biosynthesis" EXACT []
synonym: "interleukin-8 formation" EXACT []
synonym: "interleukin-8 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032637 ! interleukin-8 production

[Term]
id: GO:0042229
name: interleukin-9 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators]
synonym: "IL-9 biosynthesis" EXACT []
synonym: "IL-9 biosynthetic process" EXACT []
synonym: "interleukin-9 anabolism" EXACT []
synonym: "interleukin-9 biosynthesis" EXACT []
synonym: "interleukin-9 formation" EXACT []
synonym: "interleukin-9 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032638 ! interleukin-9 production

[Term]
id: GO:0042230
name: interleukin-11 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators]
synonym: "IL-11 biosynthesis" EXACT []
synonym: "IL-11 biosynthetic process" EXACT []
synonym: "interleukin-11 anabolism" EXACT []
synonym: "interleukin-11 biosynthesis" EXACT []
synonym: "interleukin-11 formation" EXACT []
synonym: "interleukin-11 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032614 ! interleukin-11 production

[Term]
id: GO:0042231
name: interleukin-13 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators]
synonym: "IL-13 biosynthesis" EXACT []
synonym: "IL-13 biosynthetic process" EXACT []
synonym: "interleukin-13 anabolism" EXACT []
synonym: "interleukin-13 biosynthesis" EXACT []
synonym: "interleukin-13 formation" EXACT []
synonym: "interleukin-13 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032616 ! interleukin-13 production

[Term]
id: GO:0042232
name: interleukin-14 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators]
synonym: "IL-14 biosynthesis" EXACT []
synonym: "IL-14 biosynthetic process" EXACT []
synonym: "interleukin-14 anabolism" EXACT []
synonym: "interleukin-14 biosynthesis" EXACT []
synonym: "interleukin-14 formation" EXACT []
synonym: "interleukin-14 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032617 ! interleukin-14 production

[Term]
id: GO:0042233
name: interleukin-15 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators]
synonym: "IL-15 biosynthesis" EXACT []
synonym: "IL-15 biosynthetic process" EXACT []
synonym: "interleukin-15 anabolism" EXACT []
synonym: "interleukin-15 biosynthesis" EXACT []
synonym: "interleukin-15 formation" EXACT []
synonym: "interleukin-15 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032618 ! interleukin-15 production

[Term]
id: GO:0042234
name: interleukin-16 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators]
synonym: "IL-16 biosynthesis" EXACT []
synonym: "IL-16 biosynthetic process" EXACT []
synonym: "interleukin-16 anabolism" EXACT []
synonym: "interleukin-16 biosynthesis" EXACT []
synonym: "interleukin-16 formation" EXACT []
synonym: "interleukin-16 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032619 ! interleukin-16 production

[Term]
id: GO:0042235
name: interleukin-17 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-17." [GOC:go_curators]
synonym: "IL-17 biosynthesis" EXACT []
synonym: "IL-17 biosynthetic process" EXACT []
synonym: "interleukin-17 anabolism" EXACT []
synonym: "interleukin-17 biosynthesis" EXACT []
synonym: "interleukin-17 formation" EXACT []
synonym: "interleukin-17 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032620 ! interleukin-17 production

[Term]
id: GO:0042236
name: interleukin-19 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators]
synonym: "IL-19 biosynthesis" EXACT []
synonym: "IL-19 biosynthetic process" EXACT []
synonym: "interleukin-19 anabolism" EXACT []
synonym: "interleukin-19 biosynthesis" EXACT []
synonym: "interleukin-19 formation" EXACT []
synonym: "interleukin-19 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032622 ! interleukin-19 production

[Term]
id: GO:0042237
name: interleukin-20 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators]
synonym: "IL-20 biosynthesis" EXACT []
synonym: "IL-20 biosynthetic process" EXACT []
synonym: "interleukin-20 anabolism" EXACT []
synonym: "interleukin-20 biosynthesis" EXACT []
synonym: "interleukin-20 formation" EXACT []
synonym: "interleukin-20 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032624 ! interleukin-20 production

[Term]
id: GO:0042238
name: interleukin-21 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators]
synonym: "IL-21 biosynthesis" EXACT []
synonym: "IL-21 biosynthetic process" EXACT []
synonym: "interleukin-21 anabolism" EXACT []
synonym: "interleukin-21 biosynthesis" EXACT []
synonym: "interleukin-21 formation" EXACT []
synonym: "interleukin-21 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032625 ! interleukin-21 production

[Term]
id: GO:0042239
name: interleukin-22 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators]
synonym: "IL-22 biosynthesis" EXACT []
synonym: "IL-22 biosynthetic process" EXACT []
synonym: "interleukin-22 anabolism" EXACT []
synonym: "interleukin-22 biosynthesis" EXACT []
synonym: "interleukin-22 formation" EXACT []
synonym: "interleukin-22 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032626 ! interleukin-22 production

[Term]
id: GO:0042240
name: interleukin-23 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators]
synonym: "IL-23 biosynthesis" EXACT []
synonym: "IL-23 biosynthetic process" EXACT []
synonym: "interleukin-23 anabolism" EXACT []
synonym: "interleukin-23 biosynthesis" EXACT []
synonym: "interleukin-23 formation" EXACT []
synonym: "interleukin-23 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032627 ! interleukin-23 production

[Term]
id: GO:0042241
name: interleukin-18 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators]
synonym: "IL-18 biosynthesis" EXACT []
synonym: "IL-18 biosynthetic process" EXACT []
synonym: "interleukin-18 anabolism" EXACT []
synonym: "interleukin-18 biosynthesis" EXACT []
synonym: "interleukin-18 formation" EXACT []
synonym: "interleukin-18 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032621 ! interleukin-18 production

[Term]
id: GO:0042242
name: cobyrinic acid a,c-diamide synthase activity
namespace: molecular_function
def: "Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide." [PMID:2172209]
comment: Note that this enzyme does not have an EC number yet, as its activity has not been proven experimentally. May need to be moved in the future.
subset: gosubset_prok
synonym: "CobB" NARROW []
is_a: GO:0004359 ! glutaminase activity

[Term]
id: GO:0042243
name: asexual spore wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an asexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from a product of mitosis. Examples of this process are found in Bacterial species." [GOC:mah]
subset: gosubset_prok
synonym: "asexual spore wall formation" EXACT []
is_a: GO:0042244 ! spore wall assembly
relationship: part_of GO:0030436 ! asexual sporulation

[Term]
id: GO:0042244
name: spore wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a spore wall; a spore wall is the specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg]
subset: gosubset_prok
synonym: "spore coat biosynthesis" EXACT []
synonym: "spore coat biosynthetic process" EXACT []
synonym: "spore wall formation" EXACT []
is_a: GO:0007047 ! cellular cell wall organization
is_a: GO:0070726 ! cell wall assembly
relationship: part_of GO:0070590 ! spore wall biogenesis

[Term]
id: GO:0042245
name: RNA repair
namespace: biological_process
def: "Any process by which damaged RNA can be repaired." [PMID:11000254, PMID:11070075, SP_KW:KW-0692]
subset: gosubset_prok
is_a: GO:0016070 ! RNA metabolic process

[Term]
id: GO:0042246
name: tissue regeneration
namespace: biological_process
def: "The regrowth of lost or destroyed tissues." [http://cancerweb.ncl.ac.uk/]
is_a: GO:0009888 ! tissue development
is_a: GO:0031099 ! regeneration
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0042247
name: establishment of planar polarity of follicular epithelium
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of a follicular epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]
is_a: GO:0001736 ! establishment of planar polarity
is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium

[Term]
id: GO:0042248
name: maintenance of polarity of follicular epithelium
namespace: biological_process
def: "The maintenance of an established polarized follicular epithelial sheet." [GOC:bf]
is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium

[Term]
id: GO:0042249
name: establishment of planar polarity of embryonic epithelium
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:jl, GOC:tb]
is_a: GO:0007164 ! establishment of tissue polarity

[Term]
id: GO:0042250
name: maintenance of polarity of embryonic epithelium
namespace: biological_process
def: "The maintenance of an established polarized embryonic epithelial sheet." [GOC:jl]
is_a: GO:0016332 ! establishment or maintenance of polarity of embryonic epithelium

[Term]
id: GO:0042251
name: maintenance of polarity of larval imaginal disc epithelium
namespace: biological_process
def: "The maintenance of an established polarized larval imaginal disc epithelium." [GOC:jl]
is_a: GO:0016336 ! establishment or maintenance of polarity of larval imaginal disc epithelium

[Term]
id: GO:0042252
name: establishment of planar polarity of larval imaginal disc epithelium
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of a larval imaginal disc epithelium, such that they all orient to similar coordinates." [GOC:jl]
is_a: GO:0001736 ! establishment of planar polarity

[Term]
id: GO:0042253
name: granulocyte macrophage colony-stimulating factor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor, cytokines that act in hemopoiesis by controlling the production, differentiation, and function of two related white cell populations, granulocytes and monocytes-macrophages." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "GM-CSF biosynthesis" EXACT []
synonym: "GM-CSF biosynthetic process" EXACT []
synonym: "GMC-SF biosynthesis" EXACT []
synonym: "GMC-SF biosynthetic process" EXACT []
synonym: "granulocyte macrophage colony-stimulating factor anabolism" EXACT []
synonym: "granulocyte macrophage colony-stimulating factor biosynthesis" EXACT []
synonym: "granulocyte macrophage colony-stimulating factor formation" EXACT []
synonym: "granulocyte macrophage colony-stimulating factor synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032604 ! granulocyte macrophage colony-stimulating factor production

[Term]
id: GO:0042254
name: ribosome biogenesis
namespace: biological_process
alt_id: GO:0007046
def: "The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis." [GOC:ma]
subset: goslim_candida
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "ribosomal chaperone activity" RELATED []
synonym: "ribosome biogenesis and assembly" EXACT []
xref: Wikipedia:Ribosome_biogenesis
is_a: GO:0022613 ! ribonucleoprotein complex biogenesis

[Term]
id: GO:0042255
name: ribosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma]
subset: gosubset_prok
is_a: GO:0022618 ! ribonucleoprotein complex assembly
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0042256
name: mature ribosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome." [GOC:ma]
subset: gosubset_prok
is_a: GO:0042255 ! ribosome assembly

[Term]
id: GO:0042257
name: ribosomal subunit assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form ribosomal subunits." [GOC:jl]
subset: gosubset_prok
is_a: GO:0042255 ! ribosome assembly

[Term]
id: GO:0042258
name: molybdenum incorporation via L-serinyl molybdopterin guanine dinucleotide
namespace: biological_process
def: "The incorporation of molybdenum into a protein via L-serinyl molybdopterin guanine dinucleotide." [PDB:1EU1, PMID:8658132, RESID:AA0319]
subset: gosubset_prok
xref: RESID:AA0319
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex

[Term]
id: GO:0042259
name: peptidyl-L-beta-methylthioasparagine biosynthetic process from peptidyl-asparagine
namespace: biological_process
def: "The posttranslation modification of peptidyl-asparagine to form peptidyl-L-beta-methylthioasparagine, typical of bacterial ribosomal protein S12." [GOC:jsg, RESID:AA0320]
subset: gosubset_prok
synonym: "peptidyl-L-beta-methylthioasparagine anabolism from peptidyl-asparagine" EXACT []
synonym: "peptidyl-L-beta-methylthioasparagine formation from peptidyl-asparagine" EXACT []
synonym: "peptidyl-L-beta-methylthioasparagine synthesis from peptidyl-asparagine" EXACT []
xref: RESID:AA0320
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0042262
name: DNA protection
namespace: biological_process
def: "Any process by which DNA is protected from damage by, for example, oxidative stress." [GOC:jl]
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0031668 ! cellular response to extracellular stimulus
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0042263
name: neuropeptide F receptor activity
namespace: molecular_function
def: "Combining with neuropeptide F, an invertebrate neuropeptide thought to play a role in neuroregulation, to initiate a change in cell activity. In many species, neuropeptide F is between 36 and 39 amino acid residues terminating in a phenylalaninamide residue." [GOC:ma]
is_a: GO:0008188 ! neuropeptide receptor activity

[Term]
id: GO:0042264
name: peptidyl-aspartic acid hydroxylation
namespace: biological_process
def: "The posttranslational hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid." [GOC:mah]
subset: gosubset_prok
synonym: "peptidyl-aspartic acid/asparagine hydroxylation" BROAD []
is_a: GO:0018126 ! protein amino acid hydroxylation
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0042265
name: peptidyl-asparagine hydroxylation
namespace: biological_process
def: "The posttranslational hydroxylation of peptidyl-asparagine to form peptidyl-hydroxyasparagine." [GOC:mah]
subset: gosubset_prok
synonym: "peptidyl-aspartic acid/asparagine hydroxylation" BROAD []
is_a: GO:0018126 ! protein amino acid hydroxylation
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0042267
name: natural killer cell mediated cytotoxicity
namespace: biological_process
def: "The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add]
comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
synonym: "killer activity" RELATED []
synonym: "natural killer cell mediated cell death" EXACT []
synonym: "natural killer cell mediated cell killing" EXACT []
synonym: "natural killer cell mediated cytolysis" RELATED []
synonym: "natural killer-cell mediated cytolysis" RELATED []
synonym: "NK cell mediated cell death" EXACT []
synonym: "NK cell mediated cell killing" EXACT []
synonym: "NK cell mediated cytolysis" RELATED []
synonym: "NK cell mediated cytotoxicity" EXACT []
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
is_a: GO:0002228 ! natural killer cell mediated immunity
is_a: GO:0006917 ! induction of apoptosis

[Term]
id: GO:0042268
name: regulation of cytolysis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm." [GOC:jl]
subset: gosubset_prok
is_a: GO:0010941 ! regulation of cell death
relationship: regulates GO:0019835 ! cytolysis

[Term]
id: GO:0042269
name: regulation of natural killer cell mediated cytotoxicity
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "regulation of natural killer cell mediated cell death" EXACT []
synonym: "regulation of natural killer cell mediated cell killing" EXACT []
synonym: "regulation of natural killer cell mediated cytolysis" RELATED []
synonym: "regulation of natural killer-cell mediated cytolysis" RELATED []
synonym: "regulation of NK cell mediated cell death" EXACT []
synonym: "regulation of NK cell mediated cell killing" EXACT []
synonym: "regulation of NK cell mediated cytolysis" RELATED []
synonym: "regulation of NK cell mediated cytotoxicity" RELATED []
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002715 ! regulation of natural killer cell mediated immunity
relationship: regulates GO:0042267 ! natural killer cell mediated cytotoxicity

[Term]
id: GO:0042270
name: protection from natural killer cell mediated cytotoxicity
namespace: biological_process
def: "The process of protecting a cell from natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "protection from natural killer cell mediated cell death" EXACT []
synonym: "protection from natural killer cell mediated cell killing" EXACT []
synonym: "protection from natural killer cell mediated cytolysis" RELATED []
synonym: "protection from NK cell mediated cell death" EXACT []
synonym: "protection from NK cell mediated cell killing" EXACT []
synonym: "protection from NK cell mediated cytolysis" RELATED []
synonym: "protection from NK cell mediated cytotoxicity" EXACT []
is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity

[Term]
id: GO:0042271
name: susceptibility to natural killer cell mediated cytotoxicity
namespace: biological_process
def: "The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that this term is intended for cell-surface molecules on a target cell which interact with activating receptors on a natural killer cell to promote natural killer cell mediated cytotoxicity.
synonym: "susceptibility to natural killer cell mediated cell death" EXACT []
synonym: "susceptibility to natural killer cell mediated cell killing" EXACT []
synonym: "susceptibility to natural killer cell mediated cytolysis" RELATED []
synonym: "susceptibility to NK cell mediated cell death" EXACT []
synonym: "susceptibility to NK cell mediated cell killing" EXACT []
synonym: "susceptibility to NK cell mediated cytolysis" EXACT []
synonym: "susceptibility to NK cell mediated cytotoxicity" EXACT []
is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity

[Term]
id: GO:0042272
name: nuclear RNA export factor complex
namespace: cellular_component
def: "A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm." [PMID:11780633]
synonym: "Mex67-Mtr2 complex" EXACT []
synonym: "NXF1-NXT1 complex" EXACT []
synonym: "TAP-p15 complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0042273
name: ribosomal large subunit biogenesis
namespace: biological_process
def: "The formation of the constituents of the large ribosomal subunit, their assembly, and their transport to the sites of protein synthesis." [GOC:jl]
synonym: "ribosomal large subunit biogenesis and assembly" EXACT []
is_a: GO:0022613 ! ribonucleoprotein complex biogenesis
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0042274
name: ribosomal small subunit biogenesis
namespace: biological_process
def: "The formation of the constituents of the small ribosomal subunit, their assembly, and their transport to the sites of protein synthesis." [GOC:jl]
synonym: "ribosomal small subunit biogenesis and assembly" EXACT []
is_a: GO:0022613 ! ribonucleoprotein complex biogenesis
relationship: part_of GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0042275
name: error-free postreplication DNA repair
namespace: biological_process
def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions and but does not increase the endogenous mutation rate." [GOC:elh, GOC:jl, PMID:11459630]
comment: Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication.
subset: gosubset_prok
synonym: "error-free PRR" EXACT []
synonym: "error-free replication restart" RELATED []
is_a: GO:0006301 ! postreplication repair

[Term]
id: GO:0042276
name: error-prone translesion synthesis
namespace: biological_process
def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998]
subset: gosubset_prok
synonym: "error-prone postreplication DNA repair" RELATED [GOC:elh]
synonym: "mutagenic postreplication DNA repair" RELATED [GOC:elh]
synonym: "mutagenic PRR" EXACT []
is_a: GO:0019985 ! translesion synthesis

[Term]
id: GO:0042277
name: peptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0042278
name: purine nucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713]
subset: gosubset_prok
synonym: "purine metabolic process" BROAD []
synonym: "purine metabolism" BROAD []
synonym: "purine nucleoside metabolism" EXACT []
is_a: GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0042279
name: nitrite reductase (cytochrome, ammonia-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = NO2(-) (nitrite) + 6 ferrocytochrome c + 7 H+." [EC:1.7.2.2]
subset: gosubset_prok
synonym: "ammonia:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.7.2.2]
synonym: "cytochrome c nitrite reductase activity" EXACT []
synonym: "cytochrome c552 activity" NARROW [EC:1.7.2.2]
synonym: "multiheme nitrite reductase activity" EXACT []
synonym: "nitrite reductase (cytochrome; ammonia-forming)" EXACT [EC:1.7.2.2]
xref: EC:1.7.2.2
xref: MetaCyc:1.7.2.2-RXN
xref: Wikipedia:Nitrite_reductase_(cytochrome;_ammonia-forming)
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor

[Term]
id: GO:0042280
name: cell surface antigen activity, host-interacting
namespace: molecular_function
def: "OBSOLETE. Functions as an immunogenic target for the host immune system that masks other invariant surface molecules from immune recognition." [GOC:mb]
comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity.
is_obsolete: true
consider: GO:0044403
consider: GO:0046789

[Term]
id: GO:0042281
name: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol." [MetaCyc:RXN-5470]
synonym: "dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT []
xref: EC:2.4.1.-
xref: MetaCyc:RXN-5470
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0042282
name: hydroxymethylglutaryl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+." [EC:1.1.1.88]
subset: gosubset_prok
synonym: "(R)-mevalonate:NAD+ oxidoreductase (CoA-acylating)" EXACT [EC:1.1.1.88]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A reductase activity" EXACT [EC:1.1.1.88]
synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.88]
synonym: "beta-hydroxy-beta-methylglutaryl CoA-reductase activity" BROAD [EC:1.1.1.88]
synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88]
synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.88]
synonym: "hydroxymethylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88]
synonym: "hydroxymethylglutaryl-CoA reductase (NADH) activity" EXACT [EC:1.1.1.88]
xref: EC:1.1.1.88
xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0042283
name: dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol." [MetaCyc:RXN-5471, PMID:12480927]
synonym: "dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT []
xref: EC:2.4.1.-
xref: MetaCyc:RXN-5471
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0042284
name: sphingolipid delta-4 desaturase activity
namespace: molecular_function
def: "Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid." [PMID:12417141]
synonym: "delta-4 sphingolipid desaturase activity" EXACT []
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0042285
name: xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0042286
name: glutamate-1-semialdehyde 2,1-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate." [EC:5.4.3.8]
subset: gosubset_prok
synonym: "(S)-4-amino-5-oxopentanoate 4,5-aminomutase activity" EXACT [EC:5.4.3.8]
synonym: "glutamate-1-semialdehyde aminotransferase activity" EXACT [EC:5.4.3.8]
xref: EC:5.4.3.8
xref: MetaCyc:GSAAMINOTRANS-RXN
is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups

[Term]
id: GO:0042287
name: MHC protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl]
comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein, for this also annotate to 'peptide antigen binding ; GO:0042605' or one of its children.
synonym: "major histocompatibility complex binding" EXACT []
synonym: "major histocompatibility complex ligand" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0042288
name: MHC class I protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl]
comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children.
synonym: "alpha-beta T cell receptor activity" RELATED []
synonym: "gamma-delta T cell receptor activity" RELATED []
synonym: "major histocompatibility complex class I binding" EXACT []
synonym: "major histocompatibility complex class I ligand" NARROW []
synonym: "T cell receptor activity" RELATED []
is_a: GO:0042287 ! MHC protein binding

[Term]
id: GO:0042289
name: MHC class II protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl]
comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children.
synonym: "major histocompatibility complex class II binding" EXACT []
synonym: "major histocompatibility complex class II ligand" NARROW []
is_a: GO:0042287 ! MHC protein binding

[Term]
id: GO:0042290
name: URM1 hydrolase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature.
is_obsolete: true
consider: GO:0019783

[Term]
id: GO:0042291
name: Hub1 hydrolase activity
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature.
is_obsolete: true
consider: GO:0019783

[Term]
id: GO:0042292
name: URM1 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0042293
name: Hub1 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0042294
name: URM1 conjugating enzyme activity
namespace: molecular_function
def: "Catalysis of the covalent attachment of the ubiquitin-like protein URM1 to other proteins or other substrate molecules." [GOC:mah, PMID:12826404]
is_a: GO:0019787 ! small conjugating protein ligase activity

[Term]
id: GO:0042296
name: ISG15 ligase activity
namespace: molecular_function
def: "Catalysis of the covalent attachment of the ubiquitin-like protein ISG15 to other proteins." [GOC:mah, PMID:12826404]
synonym: "ISG15 conjugating enzyme activity" EXACT []
is_a: GO:0019787 ! small conjugating protein ligase activity

[Term]
id: GO:0042297
name: vocal learning
namespace: biological_process
def: "A behavioral process whose outcome is a relatively long-lasting adaptive behavioral change whereby an organism modifies innate vocalizations to imitate or create new sounds." [PMID:16418265, PMID:17035521]
xref: Wikipedia:Vocal_learning
is_a: GO:0007612 ! learning
is_a: GO:0031223 ! auditory behavior

[Term]
id: GO:0042299
name: lupeol synthase activity
namespace: molecular_function
def: "Catalysis of the cyclization of (S)-2,3-oxidosqualene to lupeol." [PMID:9883589]
synonym: "oxidosqualene:lupeol cyclase activity" EXACT [PMID:18033581]
xref: EC:5.4.99.-
xref: MetaCyc:PWY-112
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0042300
name: beta-amyrin synthase activity
namespace: molecular_function
def: "Catalysis of the cyclization and rearrangement of 2,3-oxidosqualene into beta-amyrin." [PMID:9746369]
synonym: "oxidosqualene:beta-amyrin cyclase activity" EXACT [PMID:18033581]
xref: EC:5.4.99.-
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0042301
name: phosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphate." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0042302
name: structural constituent of cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl]
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0042303
name: molting cycle
namespace: biological_process
def: "The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0042304
name: regulation of fatty acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils." [GOC:go_curators, GOC:jl]
subset: gosubset_prok
synonym: "regulation of fatty acid anabolism" EXACT []
synonym: "regulation of fatty acid biosynthesis" EXACT []
synonym: "regulation of fatty acid formation" EXACT []
synonym: "regulation of fatty acid synthesis" EXACT []
xref: Reactome:163680 "AMPK inhibits chREBP transcriptional activation activity"
xref: Reactome:448801 "AMPK inhibits chREBP transcriptional activation activity"
xref: Reactome:469917 "AMPK inhibits chREBP transcriptional activation activity"
xref: Reactome:487623 "AMPK inhibits chREBP transcriptional activation activity"
xref: Reactome:507578 "AMPK inhibits chREBP transcriptional activation activity"
xref: Reactome:517551 "AMPK inhibits chREBP transcriptional activation activity"
xref: Reactome:526418 "AMPK inhibits chREBP transcriptional activation activity"
xref: Reactome:531241 "AMPK inhibits chREBP transcriptional activation activity"
xref: Reactome:536612 "AMPK inhibits chREBP transcriptional activation activity"
xref: Reactome:542336 "AMPK inhibits chREBP transcriptional activation activity"
xref: Reactome:547677 "AMPK inhibits chREBP transcriptional activation activity"
xref: Reactome:552261 "AMPK inhibits chREBP transcriptional activation activity"
xref: Reactome:557880 "AMPK inhibits chREBP transcriptional activation activity"
xref: Reactome:568478 "AMPK inhibits chREBP transcriptional activation activity"
xref: Reactome:581689 "AMPK inhibits chREBP transcriptional activation activity"
xref: Reactome:592596 "AMPK inhibits chREBP transcriptional activation activity"
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: regulates GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0042305
name: specification of segmental identity, mandibular segment
namespace: biological_process
def: "The specification of the characteristic structures of the mandibular segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]
comment: See also the fly_anatomy.ontology term 'mandibular segment ; FBbt:00000012'.
is_a: GO:0007380 ! specification of segmental identity, head
relationship: part_of GO:0035289 ! posterior head segmentation

[Term]
id: GO:0042306
name: regulation of protein import into nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl]
synonym: "regulation of protein import into cell nucleus" EXACT []
synonym: "regulation of protein transport from cytoplasm to nucleus" EXACT []
synonym: "regulation of protein-nucleus import" EXACT []
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
relationship: regulates GO:0006606 ! protein import into nucleus

[Term]
id: GO:0042307
name: positive regulation of protein import into nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus." [GOC:jl]
synonym: "activation of protein import into nucleus" NARROW []
synonym: "positive regulation of protein import into cell nucleus" EXACT []
synonym: "positive regulation of protein transport from cytoplasm to nucleus" EXACT []
synonym: "positive regulation of protein-nucleus import" EXACT []
synonym: "stimulation of protein import into nucleus" NARROW []
synonym: "up regulation of protein import into nucleus" EXACT []
synonym: "up-regulation of protein import into nucleus" EXACT []
synonym: "upregulation of protein import into nucleus" EXACT []
is_a: GO:0042306 ! regulation of protein import into nucleus
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0051222 ! positive regulation of protein transport
relationship: positively_regulates GO:0006606 ! protein import into nucleus

[Term]
id: GO:0042308
name: negative regulation of protein import into nucleus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [GOC:jl]
synonym: "down regulation of protein import into nucleus" EXACT []
synonym: "down-regulation of protein import into nucleus" EXACT []
synonym: "downregulation of protein import into nucleus" EXACT []
synonym: "inhibition of protein import into nucleus" NARROW []
synonym: "negative regulation of protein import into cell nucleus" EXACT []
synonym: "negative regulation of protein transport from cytoplasm to nucleus" EXACT []
synonym: "negative regulation of protein-nucleus import" EXACT []
is_a: GO:0042306 ! regulation of protein import into nucleus
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0051224 ! negative regulation of protein transport
relationship: negatively_regulates GO:0006606 ! protein import into nucleus

[Term]
id: GO:0042309
name: homoiothermy
namespace: biological_process
def: "Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment." [ISBN:0192801023]
synonym: "antifreeze activity" RELATED []
synonym: "ice nucleation activity" RELATED []
synonym: "ice nucleation inhibitor activity" RELATED []
is_a: GO:0001659 ! temperature homeostasis

[Term]
id: GO:0042310
name: vasoconstriction
namespace: biological_process
def: "A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure." [ISBN:0192800752]
synonym: "negative regulation of blood vessel size" EXACT []
xref: Wikipedia:Vasoconstriction
is_a: GO:0050880 ! regulation of blood vessel size

[Term]
id: GO:0042311
name: vasodilation
namespace: biological_process
def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure." [ISBN:0192800981]
synonym: "positive regulation of blood vessel size" EXACT []
synonym: "vasodilatation" EXACT []
xref: Wikipedia:Vasodilation
is_a: GO:0050880 ! regulation of blood vessel size

[Term]
id: GO:0042312
name: regulation of vasodilation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels." [GOC:jl]
synonym: "regulation of vasodilatation" EXACT []
is_a: GO:0044057 ! regulation of system process
relationship: regulates GO:0042311 ! vasodilation

[Term]
id: GO:0042313
name: protein kinase C deactivation
namespace: biological_process
def: "Any process resulting in the inhibition or termination of the activity of protein kinase C." [GOC:bf]
synonym: "PKC deactivation" EXACT []
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0042314
name: bacteriochlorophyll binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants." [ISBN:0192800981]
subset: gosubset_prok
is_a: GO:0016168 ! chlorophyll binding

[Term]
id: GO:0042315
name: cytosol nonspecific dipeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids." [EC:3.4.13.18]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "cytosol non-specific dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "diglycinase activity" EXACT [EC:3.4.13.18]
synonym: "Gly-Leu hydrolase activity" EXACT [EC:3.4.13.18]
synonym: "glycyl-glycine dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "glycyl-L-leucine dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "glycyl-L-leucine hydrolase activity" EXACT [EC:3.4.13.18]
synonym: "glycyl-L-leucine peptidase activity" EXACT [EC:3.4.13.18]
synonym: "glycyl-leucine dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "glycylleucine dipeptide hydrolase activity" EXACT [EC:3.4.13.18]
synonym: "glycylleucine hydrolase activity" EXACT [EC:3.4.13.18]
synonym: "glycylleucine peptidase activity" EXACT [EC:3.4.13.18]
synonym: "human cytosolic non-specific dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "iminodipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "L-amino-acyl-L-amino-acid hydrolase activity" EXACT [EC:3.4.13.18]
synonym: "L-prolylglycine dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "N(2)-beta-alanylarginine dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "N2-beta-alanylarginine dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "non-specific dipeptidase activity" EXACT [EC:3.4.13.18]
synonym: "peptidase A activity" BROAD [EC:3.4.13.18]
synonym: "Pro-X dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "prolinase activity" NARROW [EC:3.4.13.18]
synonym: "prolyl dipeptidase activity" NARROW [EC:3.4.13.18]
synonym: "prolylglycine dipeptidase activity" NARROW [EC:3.4.13.18]
xref: EC:3.4.13.18
xref: MetaCyc:3.4.13.18-RXN
is_obsolete: true
replaced_by: GO:0016805

[Term]
id: GO:0042316
name: penicillin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Penicillins are produced naturally during the growth of various microfungi of the genera Penicillium and Aspergillus." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "penicillin metabolism" EXACT []
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process
is_a: GO:0030653 ! beta-lactam antibiotic metabolic process

[Term]
id: GO:0042317
name: penicillin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "penicillin breakdown" EXACT []
synonym: "penicillin catabolism" EXACT []
synonym: "penicillin degradation" EXACT []
is_a: GO:0030655 ! beta-lactam antibiotic catabolic process
is_a: GO:0042316 ! penicillin metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0042318
name: penicillin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "penicillin anabolism" EXACT []
synonym: "penicillin biosynthesis" EXACT []
synonym: "penicillin formation" EXACT []
synonym: "penicillin synthesis" EXACT []
is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process
is_a: GO:0042316 ! penicillin metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0042320
name: regulation of circadian sleep/wake cycle, REM sleep
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep." [GOC:jl, PMID:11506998]
synonym: "regulation of REM sleep" EXACT []
is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep
relationship: regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep

[Term]
id: GO:0042321
name: negative regulation of circadian sleep/wake cycle, sleep
namespace: biological_process
def: "Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators, GOC:jl, ISBN:0192800981]
synonym: "down regulation of circadian sleep/wake cycle, sleep" EXACT []
synonym: "down-regulation of circadian sleep/wake cycle, sleep" EXACT []
synonym: "downregulation of circadian sleep/wake cycle, sleep" EXACT []
synonym: "inhibition of circadian sleep/wake cycle, sleep" NARROW []
synonym: "negative regulation of sleep" EXACT []
is_a: GO:0042754 ! negative regulation of circadian rhythm
is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep

[Term]
id: GO:0042322
name: negative regulation of circadian sleep/wake cycle, REM sleep
namespace: biological_process
def: "Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators, GOC:jl]
synonym: "down regulation of circadian sleep/wake cycle, REM sleep" EXACT []
synonym: "down-regulation of circadian sleep/wake cycle, REM sleep" EXACT []
synonym: "downregulation of circadian sleep/wake cycle, REM sleep" EXACT []
synonym: "inhibition of circadian sleep/wake cycle, REM sleep" NARROW []
synonym: "negative regulation of REM sleep" EXACT []
is_a: GO:0042320 ! regulation of circadian sleep/wake cycle, REM sleep
is_a: GO:0042321 ! negative regulation of circadian sleep/wake cycle, sleep
relationship: negatively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep

[Term]
id: GO:0042323
name: negative regulation of circadian sleep/wake cycle, non-REM sleep
namespace: biological_process
def: "Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:jl]
synonym: "down regulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
synonym: "down-regulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
synonym: "downregulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
synonym: "inhibition of circadian sleep/wake cycle, non-REM sleep" NARROW []
synonym: "negative regulation of non-REM sleep" EXACT []
is_a: GO:0042321 ! negative regulation of circadian sleep/wake cycle, sleep
is_a: GO:0045188 ! regulation of circadian sleep/wake cycle, non-REM sleep
relationship: negatively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep

[Term]
id: GO:0042324
name: hypocretin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the hypocretin receptor." [GOC:ceb, PMID:11988773]
synonym: "hypocretin receptor ligand" NARROW []
synonym: "orexin receptor binding" EXACT []
synonym: "orexin receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0042325
name: regulation of phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl]
subset: gosubset_prok
is_a: GO:0019220 ! regulation of phosphate metabolic process
relationship: regulates GO:0016310 ! phosphorylation

[Term]
id: GO:0042326
name: negative regulation of phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl]
subset: gosubset_prok
synonym: "down regulation of phosphorylation" EXACT []
synonym: "down-regulation of phosphorylation" EXACT []
synonym: "downregulation of phosphorylation" EXACT []
synonym: "inhibition of phosphorylation" NARROW []
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0045936 ! negative regulation of phosphate metabolic process
relationship: negatively_regulates GO:0016310 ! phosphorylation

[Term]
id: GO:0042327
name: positive regulation of phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl]
subset: gosubset_prok
synonym: "activation of phosphorylation" NARROW []
synonym: "stimulation of phosphorylation" NARROW []
synonym: "up regulation of phosphorylation" EXACT []
synonym: "up-regulation of phosphorylation" EXACT []
synonym: "upregulation of phosphorylation" EXACT []
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0045937 ! positive regulation of phosphate metabolic process
relationship: positively_regulates GO:0016310 ! phosphorylation

[Term]
id: GO:0042328
name: heparan sulfate N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate." [GOC:ma]
synonym: "heparan sulphate N-acetylglucosaminyltransferase activity" EXACT []
synonym: "heparin N-acetylglucosaminyltransferase activity" RELATED []
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0042329
name: structural constituent of collagen and cuticulin-based cuticle
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans." [GOC:jl, GOC:mtg_sensu]
synonym: "structural constituent of cuticle" BROAD []
is_a: GO:0042302 ! structural constituent of cuticle

[Term]
id: GO:0042330
name: taxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to an external stimulus." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "directed movement in response to stimulus" EXACT []
xref: Wikipedia:Taxis
is_a: GO:0007626 ! locomotory behavior
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0040011 ! locomotion

[Term]
id: GO:0042331
name: phototaxis
namespace: biological_process
alt_id: GO:0046953
def: "The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981]
synonym: "phototactic behavior" EXACT []
synonym: "phototactic behaviour" EXACT []
synonym: "taxis in response to light" EXACT []
xref: Wikipedia:Phototaxis
is_a: GO:0009416 ! response to light stimulus
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0042332
name: gravitaxis
namespace: biological_process
alt_id: GO:0048062
def: "The directed movement of a motile cell or organism in response to gravity." [GOC:jic, GOC:jl]
synonym: "geotactic behavior" EXACT []
synonym: "geotactic behaviour" EXACT []
synonym: "geotaxis" EXACT []
synonym: "gravitactic behavior" EXACT []
synonym: "gravitactic behaviour" EXACT []
synonym: "taxis in response to gravitational stimulus" EXACT []
synonym: "taxis in response to gravity" EXACT []
is_a: GO:0009629 ! response to gravity
is_a: GO:0042330 ! taxis

[Term]
id: GO:0042333
name: chemotaxis to oxidizable substrate
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to the presence of an oxidizable substrate, for example, fructose." [GOC:jl, PMID:11029423]
synonym: "taxis in response to oxidizable substrate" EXACT []
is_a: GO:0006935 ! chemotaxis
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0042334
name: taxis to electron acceptor
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to the presence of an alternative electron acceptor, for example, nitrate." [GOC:jl, PMID:11029423]
synonym: "taxis in response to electron acceptor" EXACT []
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0042335
name: cuticle development
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [ISBN:0192800825]
synonym: "cuticle anabolism" EXACT []
synonym: "cuticle biosynthesis" EXACT []
synonym: "cuticle biosynthetic process" EXACT []
synonym: "cuticle formation" EXACT []
synonym: "cuticle synthesis" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0042336
name: protein-based cuticle development during molting
namespace: biological_process
def: "Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. Examples of this process are found in invertebrate species." [GOC:mtg_sensu]
synonym: "cuticle anabolism during molting" BROAD []
synonym: "cuticle biosynthetic process during molting" BROAD []
synonym: "cuticle formation during molting" BROAD []
synonym: "cuticle synthesis during molting" BROAD []
is_a: GO:0007592 ! protein-based cuticle development
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0018988 ! molting cycle, protein-based cuticle

[Term]
id: GO:0042337
name: chitin-based cuticle development during molting
namespace: biological_process
def: "The synthesis and deposition of a chitin-based non-cellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu]
synonym: "cuticle anabolism during molting" BROAD []
synonym: "cuticle biosynthetic process during molting" BROAD []
synonym: "cuticle formation during molting" BROAD []
synonym: "cuticle synthesis during molting" BROAD []
is_a: GO:0040003 ! chitin-based cuticle development
is_a: GO:0042336 ! protein-based cuticle development during molting
relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle

[Term]
id: GO:0042338
name: collagen and cuticulin-based cuticle development during molting
namespace: biological_process
def: "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this process is found in Caenorhabditis elegans." [GOC:mtg_sensu]
synonym: "cuticle anabolism during molting" BROAD []
synonym: "cuticle biosynthetic process during molting" BROAD []
synonym: "cuticle formation during molting" BROAD []
synonym: "cuticle synthesis during molting" BROAD []
is_a: GO:0040002 ! collagen and cuticulin-based cuticle development
is_a: GO:0042336 ! protein-based cuticle development during molting
relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle

[Term]
id: GO:0042339
name: keratan sulfate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GOC:go_curators]
subset: gosubset_prok
synonym: "keratan sulfate metabolism" EXACT []
synonym: "keratan sulphate metabolic process" EXACT []
synonym: "keratan sulphate metabolism" EXACT []
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0042340
name: keratan sulfate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GOC:go_curators]
subset: gosubset_prok
synonym: "keratan sulfate breakdown" EXACT []
synonym: "keratan sulfate catabolism" EXACT []
synonym: "keratan sulfate degradation" EXACT []
synonym: "keratan sulphate catabolic process" EXACT []
synonym: "keratan sulphate catabolism" EXACT []
is_a: GO:0006027 ! glycosaminoglycan catabolic process
is_a: GO:0042339 ! keratan sulfate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0042341
name: cyanogenic glycoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cyanogenic glycoside metabolism" EXACT []
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:0042342
name: cyanogenic glycoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cyanogenic glycoside breakdown" EXACT []
synonym: "cyanogenic glycoside catabolism" EXACT []
synonym: "cyanogenic glycoside degradation" EXACT []
is_a: GO:0016139 ! glycoside catabolic process
is_a: GO:0042341 ! cyanogenic glycoside metabolic process

[Term]
id: GO:0042343
name: indole glucosinolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole glucosinolates. Glucosinolates are sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan; indoles are biologically active substances based on 2,3-benzopyrrole, formed during the catabolism of tryptophan." [http://www.onelook.com/]
subset: gosubset_prok
synonym: "indole glucosinolate metabolism" EXACT []
is_a: GO:0019760 ! glucosinolate metabolic process
is_a: GO:0042434 ! indole derivative metabolic process

[Term]
id: GO:0042344
name: indole glucosinolate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [http://www.onelook.com]
subset: gosubset_prok
synonym: "indole glucosinolate breakdown" EXACT []
synonym: "indole glucosinolate catabolism" EXACT []
synonym: "indole glucosinolate degradation" EXACT []
is_a: GO:0019762 ! glucosinolate catabolic process
is_a: GO:0042343 ! indole glucosinolate metabolic process
is_a: GO:0042436 ! indole derivative catabolic process

[Term]
id: GO:0042345
name: regulation of NF-kappaB import into nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "regulation of NF-kappaB import into cell nucleus" EXACT []
synonym: "regulation of NF-kappaB transport from cytoplasm to nucleus" EXACT []
synonym: "regulation of NF-kappaB-nucleus import" EXACT []
is_a: GO:0042990 ! regulation of transcription factor import into nucleus
relationship: regulates GO:0042348 ! NF-kappaB import into nucleus

[Term]
id: GO:0042346
name: positive regulation of NF-kappaB import into nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "activation of NF-kappaB import into nucleus" NARROW []
synonym: "positive regulation of NF-kappaB import into cell nucleus" EXACT []
synonym: "positive regulation of NF-kappaB transport from cytoplasm to nucleus" EXACT []
synonym: "positive regulation of NF-kappaB-nucleus import" EXACT []
synonym: "stimulation of NF-kappaB import into nucleus" NARROW []
synonym: "up regulation of NF-kappaB import into nucleus" EXACT []
synonym: "up-regulation of NF-kappaB import into nucleus" EXACT []
synonym: "upregulation of NF-kappaB import into nucleus" EXACT []
is_a: GO:0042345 ! regulation of NF-kappaB import into nucleus
is_a: GO:0042993 ! positive regulation of transcription factor import into nucleus
relationship: positively_regulates GO:0042348 ! NF-kappaB import into nucleus

[Term]
id: GO:0042347
name: negative regulation of NF-kappaB import into nucleus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "down regulation of NF-kappaB import into nucleus" EXACT []
synonym: "down-regulation of NF-kappaB import into nucleus" EXACT []
synonym: "downregulation of NF-kappaB import into nucleus" EXACT []
synonym: "inhibition of NF-kappaB import into nucleus" NARROW []
synonym: "negative regulation of NF-kappaB import into cell nucleus" EXACT []
synonym: "negative regulation of NF-kappaB transport from cytoplasm to nucleus" EXACT []
synonym: "negative regulation of NF-kappaB-nucleus import" EXACT []
is_a: GO:0042345 ! regulation of NF-kappaB import into nucleus
is_a: GO:0042992 ! negative regulation of transcription factor import into nucleus
relationship: negatively_regulates GO:0042348 ! NF-kappaB import into nucleus

[Term]
id: GO:0042348
name: NF-kappaB import into nucleus
namespace: biological_process
def: "The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "NF-kappaB import into cell nucleus" EXACT []
synonym: "NF-kappaB protein-nucleus import" EXACT []
synonym: "NF-kappaB transport from cytoplasm to nucleus" EXACT []
synonym: "NF-kappaB-nucleus import" EXACT []
is_a: GO:0042991 ! transcription factor import into nucleus

[Term]
id: GO:0042349
name: guiding stereospecific synthesis activity
namespace: molecular_function
def: "The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis." [GOC:ma]
synonym: "dirigent protein" NARROW []
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0042350
name: GDP-L-fucose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate." [GOC:jl]
subset: gosubset_prok
synonym: "GDP-L-fucose anabolism" EXACT []
synonym: "GDP-L-fucose biosynthesis" EXACT []
synonym: "GDP-L-fucose formation" EXACT []
synonym: "GDP-L-fucose synthesis" EXACT []
is_a: GO:0006005 ! L-fucose biosynthetic process
is_a: GO:0009226 ! nucleotide-sugar biosynthetic process
is_a: GO:0046368 ! GDP-L-fucose metabolic process

[Term]
id: GO:0042351
name: 'de novo' GDP-L-fucose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271)." [EC:1.1.1.271, PMID:11030750]
subset: gosubset_prok
synonym: "'de novo' GDP-L-fucose anabolism" EXACT []
synonym: "'de novo' GDP-L-fucose biosynthesis" EXACT []
synonym: "'de novo' GDP-L-fucose formation" EXACT []
synonym: "'de novo' GDP-L-fucose synthesis" EXACT []
synonym: "GDP-L-fucose biosynthesis, de novo pathway" EXACT []
synonym: "GDP-L-fucose biosynthetic process, de novo pathway" EXACT []
xref: MetaCyc:PWY-66
is_a: GO:0042350 ! GDP-L-fucose biosynthetic process

[Term]
id: GO:0042352
name: GDP-L-fucose salvage
namespace: biological_process
def: "The formation of GDP-L-fucose from L-fucose, without de novo synthesis. L-fucose is phosphorylated by fucokinase and then converted by fucose-1-phosphate guanylyltransferase (EC:2.7.7.30)." [GOC:ma]
subset: gosubset_prok
synonym: "GDP-L-fucose biosynthesis, salvage pathway" EXACT []
synonym: "GDP-L-fucose biosynthetic process, salvage pathway" EXACT []
xref: MetaCyc:PWY-6
is_a: GO:0042350 ! GDP-L-fucose biosynthetic process
is_a: GO:0043173 ! nucleotide salvage

[Term]
id: GO:0042353
name: fucose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fucose (6-deoxygalactose)." [GOC:jl]
subset: gosubset_prok
synonym: "fucose anabolism" EXACT []
synonym: "fucose biosynthesis" EXACT []
synonym: "fucose formation" EXACT []
synonym: "fucose synthesis" EXACT []
is_a: GO:0006004 ! fucose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0042354
name: L-fucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "L-fucose metabolism" EXACT []
is_a: GO:0006004 ! fucose metabolic process

[Term]
id: GO:0042355
name: L-fucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose)." [GOC:jl]
subset: gosubset_prok
synonym: "L-fucose breakdown" EXACT []
synonym: "L-fucose catabolism" EXACT []
synonym: "L-fucose degradation" EXACT []
is_a: GO:0019317 ! fucose catabolic process
is_a: GO:0042354 ! L-fucose metabolic process

[Term]
id: GO:0042356
name: GDP-4-dehydro-D-rhamnose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed." [BRENDA:1.1.1.187, EC:1.1.1.187]
subset: gosubset_prok
synonym: "GDP-4-keto-6-deoxy-D-mannose reductase activity" EXACT [EC:1.1.1.187]
synonym: "GDP-4-keto-D-rhamnose reductase activity" EXACT [EC:1.1.1.187]
synonym: "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase activity" EXACT [EC:1.1.1.187]
synonym: "guanosine diphosphate-4-keto-D-rhamnose reductase activity" EXACT [EC:1.1.1.187]
xref: EC:1.1.1.187
xref: MetaCyc:GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0042357
name: thiamin diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thiamin diphosphate, a derivative of thiamin (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "thiamin diphosphate metabolism" EXACT []
synonym: "thiamin pyrophosphate metabolic process" EXACT []
synonym: "thiamin pyrophosphate metabolism" EXACT []
synonym: "thiamine diphosphate metabolic process" EXACT []
synonym: "thiamine diphosphate metabolism" EXACT []
synonym: "thiamine pyrophosphate metabolic process" EXACT []
synonym: "thiamine pyrophosphate metabolism" EXACT []
synonym: "TPP metabolic process" EXACT []
synonym: "TPP metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0042723 ! thiamin and derivative metabolic process

[Term]
id: GO:0042358
name: thiamin diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thiamin diphosphate, a derivative of thiamin (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "thiamin diphosphate breakdown" EXACT []
synonym: "thiamin diphosphate catabolism" EXACT []
synonym: "thiamin diphosphate degradation" EXACT []
synonym: "thiamin pyrophosphate catabolic process" EXACT []
synonym: "thiamin pyrophosphate catabolism" EXACT []
synonym: "thiamine diphosphate catabolic process" EXACT []
synonym: "thiamine diphosphate catabolism" EXACT []
synonym: "thiamine pyrophosphate catabolic process" EXACT []
synonym: "thiamine pyrophosphate catabolism" EXACT []
synonym: "TPP catabolic process" EXACT []
synonym: "TPP catabolism" EXACT []
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0042357 ! thiamin diphosphate metabolic process
is_a: GO:0042725 ! thiamin and derivative catabolic process

[Term]
id: GO:0042359
name: vitamin D metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [ChEBI:27300, GOC:mah, ISBN:0471331309]
subset: gosubset_prok
synonym: "calciferol metabolic process" NARROW []
synonym: "calciferol metabolism" NARROW []
synonym: "cholecalciferol metabolic process" NARROW []
synonym: "cholecalciferol metabolism" NARROW []
synonym: "ergocalciferol metabolic process" NARROW []
synonym: "ergocalciferol metabolism" NARROW []
synonym: "vitamin D metabolism" EXACT []
is_a: GO:0006775 ! fat-soluble vitamin metabolic process
is_a: GO:0008202 ! steroid metabolic process

[Term]
id: GO:0042360
name: vitamin E metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "alpha-tocopherol metabolic process" NARROW []
synonym: "alpha-tocopherol metabolism" NARROW []
synonym: "tocopherol metabolic process" EXACT []
synonym: "tocopherol metabolism" EXACT []
synonym: "vitamin E metabolism" EXACT []
is_a: GO:0006775 ! fat-soluble vitamin metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0042361
name: menaquinone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "menaquinone breakdown" EXACT []
synonym: "menaquinone catabolism" EXACT []
synonym: "menaquinone degradation" EXACT []
synonym: "menatetrenone catabolic process" EXACT []
synonym: "menatetrenone catabolism" EXACT []
synonym: "multiprenylmenaquinone catabolic process" EXACT []
synonym: "multiprenylmenaquinone catabolism" EXACT []
synonym: "vitamin K2 catabolic process" EXACT []
synonym: "vitamin K2 catabolism" EXACT []
is_a: GO:0009233 ! menaquinone metabolic process
is_a: GO:0042377 ! vitamin K catabolic process

[Term]
id: GO:0042362
name: fat-soluble vitamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "fat-soluble vitamin anabolism" EXACT []
synonym: "fat-soluble vitamin biosynthesis" EXACT []
synonym: "fat-soluble vitamin formation" EXACT []
synonym: "fat-soluble vitamin synthesis" EXACT []
is_a: GO:0006775 ! fat-soluble vitamin metabolic process
is_a: GO:0009110 ! vitamin biosynthetic process

[Term]
id: GO:0042363
name: fat-soluble vitamin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "fat-soluble vitamin breakdown" EXACT []
synonym: "fat-soluble vitamin catabolism" EXACT []
synonym: "fat-soluble vitamin degradation" EXACT []
is_a: GO:0006775 ! fat-soluble vitamin metabolic process
is_a: GO:0009111 ! vitamin catabolic process

[Term]
id: GO:0042364
name: water-soluble vitamin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water." [GOC:jl]
subset: gosubset_prok
synonym: "water-soluble vitamin anabolism" EXACT []
synonym: "water-soluble vitamin biosynthesis" EXACT []
synonym: "water-soluble vitamin formation" EXACT []
synonym: "water-soluble vitamin synthesis" EXACT []
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0009110 ! vitamin biosynthetic process

[Term]
id: GO:0042365
name: water-soluble vitamin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in water." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "water-soluble vitamin breakdown" EXACT []
synonym: "water-soluble vitamin catabolism" EXACT []
synonym: "water-soluble vitamin degradation" EXACT []
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0009111 ! vitamin catabolic process

[Term]
id: GO:0042366
name: cobalamin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators]
subset: gosubset_prok
synonym: "cobalamin breakdown" EXACT []
synonym: "cobalamin catabolism" EXACT []
synonym: "cobalamin degradation" EXACT []
synonym: "vitamin B12 catabolic process" EXACT []
synonym: "vitamin B12 catabolism" EXACT []
is_a: GO:0006787 ! porphyrin catabolic process
is_a: GO:0009235 ! cobalamin metabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process

[Term]
id: GO:0042367
name: biotin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "biotin breakdown" EXACT []
synonym: "biotin catabolism" EXACT []
synonym: "biotin degradation" EXACT []
synonym: "vitamin B7 catabolic process" EXACT []
synonym: "vitamin B7 catabolism" EXACT []
synonym: "vitamin H catabolic process" EXACT []
synonym: "vitamin H catabolism" EXACT []
is_a: GO:0006768 ! biotin metabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0043605 ! cellular amide catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0042368
name: vitamin D biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [ChEBI:27300, GOC:mah, ISBN:0471331309]
subset: gosubset_prok
synonym: "calciferol biosynthesis" NARROW []
synonym: "calciferol biosynthetic process" NARROW []
synonym: "cholecalciferol biosynthesis" NARROW []
synonym: "cholecalciferol biosynthetic process" NARROW []
synonym: "ergocalciferol biosynthesis" NARROW []
synonym: "ergocalciferol biosynthetic process" NARROW []
synonym: "vitamin D anabolism" EXACT []
synonym: "vitamin D biosynthesis" EXACT []
synonym: "vitamin D formation" EXACT []
synonym: "vitamin D synthesis" EXACT []
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0042359 ! vitamin D metabolic process
is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process

[Term]
id: GO:0042369
name: vitamin D catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [ChEBI:27300, GOC:mah, ISBN:0471331309]
subset: gosubset_prok
synonym: "calciferol catabolic process" NARROW []
synonym: "calciferol catabolism" NARROW []
synonym: "cholecalciferol biosynthesis" NARROW []
synonym: "cholecalciferol biosynthetic process" NARROW []
synonym: "ergocalciferol biosynthesis" NARROW []
synonym: "ergocalciferol biosynthetic process" NARROW []
synonym: "vitamin D breakdown" EXACT []
synonym: "vitamin D catabolism" EXACT []
synonym: "vitamin D degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0042359 ! vitamin D metabolic process
is_a: GO:0042363 ! fat-soluble vitamin catabolic process

[Term]
id: GO:0042370
name: thiamin diphosphate dephosphorylation
namespace: biological_process
def: "The removal of one or more phosphate groups from thiamin diphosphate, a derivative of thiamin (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "thiamine diphosphate dephosphorylation" EXACT []
synonym: "TPP dephosphorylation" EXACT []
is_a: GO:0042357 ! thiamin diphosphate metabolic process

[Term]
id: GO:0042371
name: vitamin K biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "naphthoquinone metabolic process" BROAD []
synonym: "naphthoquinone metabolism" BROAD []
synonym: "vitamin K anabolism" EXACT []
synonym: "vitamin K biosynthesis" EXACT []
synonym: "vitamin K formation" EXACT []
synonym: "vitamin K synthesis" EXACT []
is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process
is_a: GO:0042373 ! vitamin K metabolic process
is_a: GO:0045426 ! quinone cofactor biosynthetic process

[Term]
id: GO:0042372
name: phylloquinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "phylloquinone anabolism" EXACT []
synonym: "phylloquinone biosynthesis" EXACT []
synonym: "phylloquinone formation" EXACT []
synonym: "phylloquinone synthesis" EXACT []
synonym: "phytomenadione biosynthesis" EXACT []
synonym: "phytomenadione biosynthetic process" EXACT []
synonym: "phytonadione biosynthesis" EXACT []
synonym: "phytonadione biosynthetic process" EXACT []
synonym: "phytylmenaquinone biosynthesis" EXACT []
synonym: "phytylmenaquinone biosynthetic process" EXACT []
synonym: "vitamin K1 biosynthesis" EXACT []
synonym: "vitamin K1 biosynthetic process" EXACT []
xref: MetaCyc:PWY-5027
is_a: GO:0042371 ! vitamin K biosynthetic process
is_a: GO:0042374 ! phylloquinone metabolic process

[Term]
id: GO:0042373
name: vitamin K metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "naphthoquinone metabolic process" BROAD []
synonym: "naphthoquinone metabolism" BROAD []
synonym: "vitamin K metabolism" EXACT []
is_a: GO:0006775 ! fat-soluble vitamin metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0042375 ! quinone cofactor metabolic process

[Term]
id: GO:0042374
name: phylloquinone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phylloquinone, a quinone-derived compound synthesized by green plants. Phylloquinone has vitamin K activity and is known as vitamin K1." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "phylloquinone metabolism" EXACT []
synonym: "phytomenadione metabolic process" EXACT []
synonym: "phytomenadione metabolism" EXACT []
synonym: "phytonadione metabolic process" EXACT []
synonym: "phytonadione metabolism" EXACT []
synonym: "phytylmenaquinone metabolic process" EXACT []
synonym: "phytylmenaquinone metabolism" EXACT []
synonym: "vitamin K1 metabolic process" EXACT []
synonym: "vitamin K1 metabolism" EXACT []
is_a: GO:0042373 ! vitamin K metabolic process

[Term]
id: GO:0042375
name: quinone cofactor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving quinone cofactors." [GOC:go_curators]
subset: gosubset_prok
synonym: "quinone cofactor metabolism" EXACT []
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0042376
name: phylloquinone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "phylloquinone breakdown" EXACT []
synonym: "phylloquinone catabolism" EXACT []
synonym: "phylloquinone degradation" EXACT []
synonym: "phytomenadione catabolic process" EXACT []
synonym: "phytomenadione catabolism" EXACT []
synonym: "phytonadione catabolic process" EXACT []
synonym: "phytonadione catabolism" EXACT []
synonym: "phytylmenaquinone catabolic process" EXACT []
synonym: "phytylmenaquinone catabolism" EXACT []
synonym: "vitamin K1 catabolic process" EXACT []
synonym: "vitamin K1 catabolism" EXACT []
is_a: GO:0042374 ! phylloquinone metabolic process
is_a: GO:0042377 ! vitamin K catabolic process

[Term]
id: GO:0042377
name: vitamin K catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]
subset: gosubset_prok
synonym: "naphthoquinone catabolic process" EXACT []
synonym: "naphthoquinone catabolism" EXACT []
synonym: "vitamin K breakdown" EXACT []
synonym: "vitamin K catabolism" EXACT []
synonym: "vitamin K degradation" EXACT []
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0042363 ! fat-soluble vitamin catabolic process
is_a: GO:0042373 ! vitamin K metabolic process
is_a: GO:0042378 ! quinone cofactor catabolic process

[Term]
id: GO:0042378
name: quinone cofactor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of quinone cofactors." [GOC:go_curators]
subset: gosubset_prok
synonym: "quinone cofactor breakdown" EXACT []
synonym: "quinone cofactor catabolism" EXACT []
synonym: "quinone cofactor degradation" EXACT []
is_a: GO:0009109 ! coenzyme catabolic process
is_a: GO:0042375 ! quinone cofactor metabolic process

[Term]
id: GO:0042379
name: chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any chemokine receptor." [GOC:ai]
synonym: "chemokine receptor ligand" NARROW []
is_a: GO:0001664 ! G-protein-coupled receptor binding
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0042380
name: hydroxymethylbutenyl pyrophosphate reductase activity
namespace: molecular_function
def: "Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate." [GOC:js]
comment: Note that the enzyme performing this function has only recently been characterized, and not completely (see PMID:11818558). The common and systematic names have been suggested by TIGR, who have recently compiled an HMM model for this gene (TIGR00216). The enzyme appears to catalyze the final step in the non-mevalonate terpene biosynthesis pathway. Its two products, isopentenyl pyrophosphate and dimethylallyl pyrophosphate, are apparently generated from a common intermediate formed by the enzyme. The mechanism and identity of the reductant have not yet been determined.
subset: gosubset_prok
synonym: "(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)" EXACT []
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0042381
name: hemolymph coagulation
namespace: biological_process
def: "Any process by which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:10561606, PMID:11915949]
synonym: "hemolymph clotting" EXACT []
is_a: GO:0006959 ! humoral immune response
is_a: GO:0007599 ! hemostasis
is_a: GO:0045087 ! innate immune response
is_a: GO:0050817 ! coagulation
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0042382
name: paraspeckles
namespace: cellular_component
def: "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299]
xref: Wikipedia:Paraspeckle
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0042383
name: sarcolemma
namespace: cellular_component
def: "The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: Wikipedia:Sarcolemma
is_a: GO:0005886 ! plasma membrane

[Term]
id: GO:0042384
name: cilium assembly
namespace: biological_process
def: "The assembly of a cilium, a specialized eukaryotic locomotor organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "ciliogenesis" EXACT []
synonym: "cilium biogenesis" RELATED [GOC:mah]
is_a: GO:0030031 ! cell projection assembly
relationship: part_of GO:0060271 ! cilium morphogenesis

[Term]
id: GO:0042385
name: myosin III complex
namespace: cellular_component
def: "A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain." [GOC:jl, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0042386
name: hemocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:jl, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk/, PMID:9550723]
synonym: "arthropod blood cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0042387
name: plasmatocyte differentiation
namespace: biological_process
def: "The process by which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response." [PMID:11921077, PMID:8174791]
is_a: GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0042388
name: gibberellic acid mediated signaling pathway, G-alpha-dependent
namespace: biological_process
def: "A series of molecular signals mediated by the detection of gibberellic acid and dependent on the coupling of the alpha subunit of G proteins to the hormone receptors." [GOC:pj, PMID:11027362]
synonym: "gibberellic acid mediated signalling, G-alpha-dependent" EXACT []
is_a: GO:0009740 ! gibberellic acid mediated signaling pathway

[Term]
id: GO:0042389
name: omega-3 fatty acid desaturase activity
namespace: molecular_function
def: "Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain." [GOC:jl, PMID:9037020]
xref: EC:1.14.99.-
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0042390
name: gibberellic acid mediated signaling pathway, G-alpha-independent
namespace: biological_process
def: "A series of molecular signals mediated by the detection of gibberellic acid and not dependent on the coupling of the alpha subunit of G proteins to the hormone receptors." [GOC:pj, PMID:11027362]
synonym: "gibberellic acid mediated signalling, G-alpha-independent" EXACT []
is_a: GO:0009740 ! gibberellic acid mediated signaling pathway

[Term]
id: GO:0042391
name: regulation of membrane potential
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0006873 ! cellular ion homeostasis

[Term]
id: GO:0042392
name: sphingosine-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [GOC:jl, PMID:11331102]
synonym: "sphingosine-1-phosphate phosphohydrolase activity" EXACT []
synonym: "SPP phosphatase activity" EXACT []
synonym: "SPPase activity" EXACT []
xref: MetaCyc:RXN3DJ-25
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0042393
name: histone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl]
synonym: "histone-specific chaperone activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0042394
name: ecdysis, protein-based cuticle
namespace: biological_process
def: "The shedding of the old protein-based cuticular fragments during the molting cycle. Examples of this process are found in invertebrates." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0022404 ! molting cycle process
relationship: part_of GO:0018988 ! molting cycle, protein-based cuticle

[Term]
id: GO:0042395
name: ecdysis, collagen and cuticulin-based cuticle
namespace: biological_process
def: "The shedding of the old collagen and cuticulin-based cuticle fragments during the molting cycle. Examples of this process are found in invertebrates." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0042394 ! ecdysis, protein-based cuticle
relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle

[Term]
id: GO:0042396
name: phosphagen biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphagen anabolism" EXACT []
synonym: "phosphagen biosynthesis" EXACT []
synonym: "phosphagen formation" EXACT []
synonym: "phosphagen synthesis" EXACT []
is_a: GO:0006599 ! phosphagen metabolic process
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process

[Term]
id: GO:0042397
name: phosphagen catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphagen breakdown" EXACT []
synonym: "phosphagen catabolism" EXACT []
synonym: "phosphagen degradation" EXACT []
is_a: GO:0006599 ! phosphagen metabolic process
is_a: GO:0042219 ! cellular amino acid derivative catabolic process

[Term]
id: GO:0042398
name: cellular amino acid derivative biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]
subset: gosubset_prok
synonym: "cellular amino acid derivative anabolism" EXACT []
synonym: "cellular amino acid derivative biosynthesis" EXACT []
synonym: "cellular amino acid derivative formation" EXACT []
synonym: "cellular amino acid derivative synthesis" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process

[Term]
id: GO:0042399
name: ectoine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218]
subset: gosubset_prok
synonym: "ectoine metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0042400
name: ectoine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218]
subset: gosubset_prok
synonym: "ectoine breakdown" EXACT []
synonym: "ectoine catabolism" EXACT []
synonym: "ectoine degradation" EXACT []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042399 ! ectoine metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0042401
name: cellular biogenic amine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172]
subset: gosubset_prok
synonym: "biogenic amine anabolism" EXACT []
synonym: "biogenic amine biosynthesis" EXACT []
synonym: "biogenic amine formation" EXACT []
synonym: "biogenic amine synthesis" EXACT []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
is_a: GO:0009309 ! amine biosynthetic process
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process

[Term]
id: GO:0042402
name: cellular biogenic amine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:go_curators, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "biogenic amine breakdown" EXACT []
synonym: "biogenic amine catabolism" EXACT []
synonym: "biogenic amine degradation" EXACT []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
is_a: GO:0009310 ! amine catabolic process
is_a: GO:0042219 ! cellular amino acid derivative catabolic process

[Term]
id: GO:0042403
name: thyroid hormone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "thyroid hormone metabolism" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0042404
name: thyroid hormone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "thyroid hormone breakdown" EXACT []
synonym: "thyroid hormone catabolism" EXACT []
synonym: "thyroid hormone degradation" EXACT []
is_a: GO:0009310 ! amine catabolic process
is_a: GO:0042403 ! thyroid hormone metabolic process
is_a: GO:0042447 ! hormone catabolic process

[Term]
id: GO:0042405
name: nuclear inclusion body
namespace: cellular_component
def: "An intranuclear focus at which aggregated proteins have been sequestered." [GOC:jl]
is_a: GO:0016234 ! inclusion body
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0042406
name: extrinsic to endoplasmic reticulum membrane
namespace: cellular_component
def: "Loosely bound to one surface of the endoplasmic reticulum membrane, but not integrated into the hydrophobic region." [GOC:jl, http://cancerweb.ncl.ac.uk/]
synonym: "extrinsic to ER membrane" EXACT []
is_a: GO:0031312 ! extrinsic to organelle membrane
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0042407
name: cristae formation
namespace: biological_process
def: "The assembly of cristae, the inwards folds of the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0007007 ! inner mitochondrial membrane organization

[Term]
id: GO:0042408
name: myrcene/(E)-beta-ocimene synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the conversion of geranyl diphosphate (GPP) into the acyclic monoterpenes beta-myrcene, (E)-beta-ocimene, and other minor cyclic monoterpenes." [GOC:cr, PMID:10700382]
comment: This term was made obsolete because it represents two activities.
synonym: "myrcene/ocimene synthase activity" EXACT []
xref: EC:4.6.-.-
is_obsolete: true

[Term]
id: GO:0042409
name: caffeoyl-CoA O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA." [EC:2.1.1.104]
subset: gosubset_prok
synonym: "caffeoyl coenzyme A methyltransferase activity" EXACT []
synonym: "caffeoyl-CoA 3-O-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase activity" EXACT [EC:2.1.1.104]
synonym: "trans-caffeoyl-CoA 3-O-methyltransferase activity" EXACT [EC:2.1.1.104]
xref: EC:2.1.1.104
xref: MetaCyc:CAFFEOYL-COA-O-METHYLTRANSFERASE-RXN
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0042410
name: 6-carboxyhexanoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA." [EC:6.2.1.14]
subset: gosubset_prok
synonym: "6-carboxyhexanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.14]
synonym: "6-carboxyhexanoyl-CoA synthetase activity" EXACT [EC:6.2.1.14]
synonym: "pimeloyl-CoA synthetase activity" EXACT [EC:6.2.1.14]
synonym: "pimelyl-CoA synthetase activity" EXACT [EC:6.2.1.14]
xref: EC:6.2.1.14
xref: MetaCyc:6-CARBOXYHEXANOATE--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0042412
name: taurine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461]
subset: gosubset_prok
synonym: "taurine anabolism" EXACT []
synonym: "taurine biosynthesis" EXACT []
synonym: "taurine formation" EXACT []
synonym: "taurine synthesis" EXACT []
is_a: GO:0019530 ! taurine metabolic process
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0042413
name: carnitine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "carnitine breakdown" EXACT []
synonym: "carnitine catabolism" EXACT []
synonym: "carnitine degradation" EXACT []
synonym: "vitamin Bt catabolic process" EXACT []
synonym: "vitamin Bt catabolism" EXACT []
is_a: GO:0006579 ! betaine catabolic process
is_a: GO:0009437 ! carnitine metabolic process

[Term]
id: GO:0042414
name: epinephrine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "adrenaline metabolic process" EXACT []
synonym: "adrenaline metabolism" EXACT []
synonym: "epinephrine metabolism" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0042415
name: norepinephrine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "levarterenol metabolic process" EXACT []
synonym: "levarterenol metabolism" EXACT []
synonym: "noradrenaline metabolic process" EXACT []
synonym: "noradrenaline metabolism" EXACT []
synonym: "norepinephrine metabolism" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0042416
name: dopamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "dopamine anabolism" EXACT []
synonym: "dopamine biosynthesis" EXACT []
synonym: "dopamine formation" EXACT []
synonym: "dopamine synthesis" EXACT []
is_a: GO:0042417 ! dopamine metabolic process
is_a: GO:0042423 ! catecholamine biosynthetic process

[Term]
id: GO:0042417
name: dopamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "dopamine metabolism" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0042418
name: epinephrine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "adrenaline biosynthesis" EXACT []
synonym: "adrenaline biosynthetic process" EXACT []
synonym: "epinephrine anabolism" EXACT []
synonym: "epinephrine biosynthesis" EXACT []
synonym: "epinephrine formation" EXACT []
synonym: "epinephrine synthesis" EXACT []
is_a: GO:0042414 ! epinephrine metabolic process
is_a: GO:0042423 ! catecholamine biosynthetic process

[Term]
id: GO:0042419
name: epinephrine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "adrenaline catabolic process" EXACT []
synonym: "adrenaline catabolism" EXACT []
synonym: "epinephrine breakdown" EXACT []
synonym: "epinephrine catabolism" EXACT []
synonym: "epinephrine degradation" EXACT []
is_a: GO:0042414 ! epinephrine metabolic process
is_a: GO:0042424 ! catecholamine catabolic process

[Term]
id: GO:0042420
name: dopamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "dopamine breakdown" EXACT []
synonym: "dopamine catabolism" EXACT []
synonym: "dopamine degradation" EXACT []
is_a: GO:0042417 ! dopamine metabolic process
is_a: GO:0042424 ! catecholamine catabolic process

[Term]
id: GO:0042421
name: norepinephrine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "levarterenol biosynthesis" EXACT []
synonym: "levarterenol biosynthetic process" EXACT []
synonym: "noradrenaline biosynthesis" EXACT []
synonym: "noradrenaline biosynthetic process" EXACT []
synonym: "norepinephrine anabolism" EXACT []
synonym: "norepinephrine biosynthesis" EXACT []
synonym: "norepinephrine formation" EXACT []
synonym: "norepinephrine synthesis" EXACT []
is_a: GO:0042415 ! norepinephrine metabolic process
is_a: GO:0042423 ! catecholamine biosynthetic process

[Term]
id: GO:0042422
name: norepinephrine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "levarterenol catabolic process" EXACT []
synonym: "levarterenol catabolism" EXACT []
synonym: "noradrenaline catabolic process" EXACT []
synonym: "noradrenaline catabolism" EXACT []
synonym: "norepinephrine breakdown" EXACT []
synonym: "norepinephrine catabolism" EXACT []
synonym: "norepinephrine degradation" EXACT []
xref: Wikipedia:Norepinephrine#Degradation
is_a: GO:0042415 ! norepinephrine metabolic process
is_a: GO:0042424 ! catecholamine catabolic process

[Term]
id: GO:0042423
name: catecholamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "catecholamine anabolism" EXACT []
synonym: "catecholamine biosynthesis" EXACT []
synonym: "catecholamine formation" EXACT []
synonym: "catecholamine synthesis" EXACT []
xref: Wikipedia:Catecholamines
is_a: GO:0006584 ! catecholamine metabolic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process

[Term]
id: GO:0042424
name: catecholamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "catecholamine breakdown" EXACT []
synonym: "catecholamine catabolism" EXACT []
synonym: "catecholamine degradation" EXACT []
is_a: GO:0006584 ! catecholamine metabolic process
is_a: GO:0019614 ! catechol catabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process

[Term]
id: GO:0042425
name: choline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "choline anabolism" EXACT []
synonym: "choline biosynthesis" EXACT []
synonym: "choline formation" EXACT []
synonym: "choline synthesis" EXACT []
xref: MetaCyc:PWY-4762
is_a: GO:0019695 ! choline metabolic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0042426
name: choline catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023]
subset: gosubset_prok
synonym: "choline breakdown" EXACT []
synonym: "choline catabolism" EXACT []
synonym: "choline degradation" EXACT []
is_a: GO:0019695 ! choline metabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0042427
name: serotonin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "serotonin anabolism" EXACT []
synonym: "serotonin biosynthesis" EXACT []
synonym: "serotonin formation" EXACT []
synonym: "serotonin synthesis" EXACT []
xref: Wikipedia:Serotonin
is_a: GO:0042428 ! serotonin metabolic process
is_a: GO:0046219 ! indolalkylamine biosynthetic process

[Term]
id: GO:0042428
name: serotonin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "serotonin metabolism" EXACT []
is_a: GO:0006586 ! indolalkylamine metabolic process

[Term]
id: GO:0042429
name: serotonin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "serotonin breakdown" EXACT []
synonym: "serotonin catabolism" EXACT []
synonym: "serotonin degradation" EXACT []
is_a: GO:0042428 ! serotonin metabolic process
is_a: GO:0046218 ! indolalkylamine catabolic process

[Term]
id: GO:0042430
name: indole and derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan) formed in degradation of tryptophan, and compounds derived from it." [GOC:jl]
subset: gosubset_prok
synonym: "indole and derivative metabolism" EXACT []
synonym: "ketole metabolic process" EXACT []
synonym: "ketole metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0042431
name: indole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "indole metabolism" EXACT []
is_a: GO:0042430 ! indole and derivative metabolic process

[Term]
id: GO:0042432
name: indole biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "indole anabolism" EXACT []
synonym: "indole biosynthesis" EXACT []
synonym: "indole formation" EXACT []
synonym: "indole synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042431 ! indole metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process

[Term]
id: GO:0042433
name: indole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "indole breakdown" EXACT []
synonym: "indole catabolism" EXACT []
synonym: "indole degradation" EXACT []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042431 ! indole metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0042434
name: indole derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving compounds derived from indole (2,3-benzopyrrole)." [GOC:jl]
subset: gosubset_prok
synonym: "indole derivative metabolism" EXACT []
is_a: GO:0042430 ! indole and derivative metabolic process

[Term]
id: GO:0042435
name: indole derivative biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of compounds derived from indole (2,3-benzopyrrole)." [GOC:jl]
subset: gosubset_prok
synonym: "indole derivative anabolism" EXACT []
synonym: "indole derivative biosynthesis" EXACT []
synonym: "indole derivative formation" EXACT []
synonym: "indole derivative synthesis" EXACT []
is_a: GO:0042434 ! indole derivative metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0042436
name: indole derivative catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of compounds derived from indole (2,3-benzopyrrole)." [GOC:jl]
subset: gosubset_prok
synonym: "indole derivative breakdown" EXACT []
synonym: "indole derivative catabolism" EXACT []
synonym: "indole derivative degradation" EXACT []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042434 ! indole derivative metabolic process

[Term]
id: GO:0042437
name: indoleacetic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:jl]
subset: gosubset_prok
synonym: "IAA catabolic process" EXACT []
synonym: "indole acetic acid catabolic process" EXACT []
synonym: "indole acetic acid catabolism" EXACT []
synonym: "indoleacetic acid breakdown" EXACT []
synonym: "indoleacetic acid catabolism" EXACT []
synonym: "indoleacetic acid degradation" EXACT []
is_a: GO:0009683 ! indoleacetic acid metabolic process
is_a: GO:0009852 ! auxin catabolic process
is_a: GO:0042436 ! indole derivative catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0042438
name: melanin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "melanin anabolism" EXACT []
synonym: "melanin biosynthesis" EXACT []
synonym: "melanin formation" EXACT []
synonym: "melanin synthesis" EXACT []
is_a: GO:0006582 ! melanin metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0042439
name: ethanolamine and derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it." [ChEBI:16000, GOC:mah]
subset: gosubset_prok
synonym: "ethanolamine and derivative metabolism" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0006576 ! cellular biogenic amine metabolic process

[Term]
id: GO:0042440
name: pigment metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
synonym: "pigment metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0042441
name: eye pigment metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]
synonym: "eye pigment metabolism" EXACT []
is_a: GO:0043324 ! pigment metabolic process during developmental pigmentation
relationship: part_of GO:0048069 ! eye pigmentation

[Term]
id: GO:0042442
name: melatonin catabolic process
namespace: biological_process
alt_id: GO:0042449
def: "The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:jl]
subset: gosubset_prok
synonym: "melatonin breakdown" EXACT []
synonym: "melatonin catabolism" EXACT []
synonym: "melatonin degradation" EXACT []
is_a: GO:0030186 ! melatonin metabolic process
is_a: GO:0042447 ! hormone catabolic process
is_a: GO:0046218 ! indolalkylamine catabolic process

[Term]
id: GO:0042443
name: phenylethylamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172]
synonym: "phenylethylamine metabolism" EXACT []
is_a: GO:0006576 ! cellular biogenic amine metabolic process
is_a: GO:0042133 ! neurotransmitter metabolic process

[Term]
id: GO:0042444
name: phenylethylamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172]
synonym: "phenylethylamine anabolism" EXACT []
synonym: "phenylethylamine biosynthesis" EXACT []
synonym: "phenylethylamine formation" EXACT []
synonym: "phenylethylamine synthesis" EXACT []
is_a: GO:0042136 ! neurotransmitter biosynthetic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process
is_a: GO:0042443 ! phenylethylamine metabolic process

[Term]
id: GO:0042445
name: hormone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: goslim_pir
subset: gosubset_prok
synonym: "hormone metabolism" EXACT []
xref: Reactome:436289 "Dehydrogenation of Testosterone to form 6-Dehydrotestosterone"
xref: Reactome:458699 "Dehydrogenation of Testosterone to form 6-Dehydrotestosterone"
xref: Reactome:478024 "Dehydrogenation of Testosterone to form 6-Dehydrotestosterone"
xref: Reactome:497682 "Dehydrogenation of Testosterone to form 6-Dehydrotestosterone"
xref: Reactome:512826 "Dehydrogenation of Testosterone to form 6-Dehydrotestosterone"
xref: Reactome:521993 "Dehydrogenation of Testosterone to form 6-Dehydrotestosterone"
xref: Reactome:528938 "Dehydrogenation of Testosterone to form 6-Dehydrotestosterone"
xref: Reactome:534163 "Dehydrogenation of Testosterone to form 6-Dehydrotestosterone"
xref: Reactome:539659 "Dehydrogenation of Testosterone to form 6-Dehydrotestosterone"
xref: Reactome:550173 "Dehydrogenation of Testosterone to form 6-Dehydrotestosterone"
xref: Reactome:555346 "Dehydrogenation of Testosterone to form 6-Dehydrotestosterone"
xref: Reactome:564263 "Dehydrogenation of Testosterone to form 6-Dehydrotestosterone"
xref: Reactome:576523 "Dehydrogenation of Testosterone to form 6-Dehydrotestosterone"
xref: Reactome:589474 "Dehydrogenation of Testosterone to form 6-Dehydrotestosterone"
xref: Reactome:601556 "Dehydrogenation of Testosterone to form 6-Dehydrotestosterone"
xref: Reactome:76521 "Dehydrogenation of Testosterone to form 6-Dehydrotestosterone"
is_a: GO:0008152 ! metabolic process
is_a: GO:0010817 ! regulation of hormone levels

[Term]
id: GO:0042446
name: hormone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "hormone anabolism" EXACT []
synonym: "hormone biosynthesis" EXACT []
synonym: "hormone formation" EXACT []
synonym: "hormone synthesis" EXACT []
xref: Reactome:209945 "Hormone biosynthesis"
xref: Reactome:448496 "Hormone biosynthesis"
xref: Reactome:469626 "Hormone biosynthesis"
xref: Reactome:487345 "Hormone biosynthesis"
xref: Reactome:507296 "Hormone biosynthesis"
xref: Reactome:517310 "Hormone biosynthesis"
xref: Reactome:526195 "Hormone biosynthesis"
xref: Reactome:531342 "Hormone biosynthesis"
xref: Reactome:536828 "Hormone biosynthesis"
xref: Reactome:542456 "Hormone biosynthesis"
xref: Reactome:547867 "Hormone biosynthesis"
xref: Reactome:552479 "Hormone biosynthesis"
xref: Reactome:557699 "Hormone biosynthesis"
xref: Reactome:568612 "Hormone biosynthesis"
xref: Reactome:581816 "Hormone biosynthesis"
xref: Reactome:585979 "Hormone biosynthesis"
xref: Reactome:592731 "Hormone biosynthesis"
xref: Reactome:595577 "Hormone biosynthesis"
xref: Reactome:597412 "Hormone biosynthesis"
xref: Reactome:602605 "Hormone biosynthesis"
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0042447
name: hormone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "hormone breakdown" EXACT []
synonym: "hormone catabolism" EXACT []
synonym: "hormone degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0042445 ! hormone metabolic process

[Term]
id: GO:0042448
name: progesterone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/]
synonym: "progesterone metabolism" EXACT []
is_a: GO:0008207 ! C21-steroid hormone metabolic process

[Term]
id: GO:0042450
name: arginine biosynthetic process via ornithine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine." [GOC:jl]
subset: gosubset_prok
synonym: "arginine anabolism via ornithine" EXACT []
synonym: "arginine formation via ornithine" EXACT []
synonym: "arginine synthesis via ornithine" EXACT []
is_a: GO:0006526 ! arginine biosynthetic process
is_a: GO:0006591 ! ornithine metabolic process

[Term]
id: GO:0042451
name: purine nucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators]
subset: gosubset_prok
synonym: "purine nucleoside anabolism" EXACT []
synonym: "purine nucleoside biosynthesis" EXACT []
synonym: "purine nucleoside formation" EXACT []
synonym: "purine nucleoside synthesis" EXACT []
is_a: GO:0009163 ! nucleoside biosynthetic process
is_a: GO:0042278 ! purine nucleoside metabolic process

[Term]
id: GO:0042452
name: deoxyguanosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "deoxyguanosine anabolism" EXACT []
synonym: "deoxyguanosine biosynthesis" EXACT []
synonym: "deoxyguanosine formation" EXACT []
synonym: "deoxyguanosine synthesis" EXACT []
is_a: GO:0042453 ! deoxyguanosine metabolic process
is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0042453
name: deoxyguanosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "deoxyguanosine metabolism" EXACT []
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0042454
name: ribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "ribonucleoside breakdown" EXACT []
synonym: "ribonucleoside catabolism" EXACT []
synonym: "ribonucleoside degradation" EXACT []
is_a: GO:0009119 ! ribonucleoside metabolic process
is_a: GO:0009164 ! nucleoside catabolic process

[Term]
id: GO:0042455
name: ribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "ribonucleoside anabolism" EXACT []
synonym: "ribonucleoside biosynthesis" EXACT []
synonym: "ribonucleoside formation" EXACT []
synonym: "ribonucleoside synthesis" EXACT []
is_a: GO:0009119 ! ribonucleoside metabolic process
is_a: GO:0009163 ! nucleoside biosynthetic process

[Term]
id: GO:0042457
name: ethylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:jl, ISBN:0387969845]
subset: gosubset_prok
synonym: "ethene catabolic process" EXACT []
synonym: "ethene catabolism" EXACT []
synonym: "ethylene breakdown" EXACT []
synonym: "ethylene catabolism" EXACT []
synonym: "ethylene degradation" EXACT []
is_a: GO:0009692 ! ethylene metabolic process
is_a: GO:0042219 ! cellular amino acid derivative catabolic process
is_a: GO:0043451 ! alkene catabolic process

[Term]
id: GO:0042458
name: nopaline catabolic process to proline
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nopaline into other compounds, including proline." [GOC:go_curators]
subset: gosubset_prok
synonym: "nopaline breakdown to proline" EXACT []
synonym: "nopaline degradation to proline" EXACT []
xref: MetaCyc:NOPALINEDEG-PWY
is_a: GO:0006560 ! proline metabolic process
is_a: GO:0019468 ! nopaline catabolic process

[Term]
id: GO:0042459
name: octopine catabolic process to proline
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of octopine into other compounds, including proline." [GOC:go_curators]
subset: gosubset_prok
synonym: "octopine breakdown to proline" EXACT []
synonym: "octopine degradation to proline" EXACT []
xref: MetaCyc:OCTOPINEDEG-PWY
is_a: GO:0006560 ! proline metabolic process
is_a: GO:0019469 ! octopine catabolic process

[Term]
id: GO:0042461
name: photoreceptor cell development
namespace: biological_process
alt_id: GO:0046531
def: "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators]
synonym: "photoreceptor morphogenesis" EXACT []
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0042462
name: eye photoreceptor cell development
namespace: biological_process
def: "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve." [GOC:jl, ISBN:0192800981]
is_a: GO:0042461 ! photoreceptor cell development
relationship: part_of GO:0001754 ! eye photoreceptor cell differentiation

[Term]
id: GO:0042463
name: ocellus photoreceptor cell development
namespace: biological_process
alt_id: GO:0001749
def: "Development of photoreceptors, sensory cells that react to the presence of light, found in the ocellus." [GOC:jl, ISBN:0192800981, PMID:11542766]
synonym: "non-eye photoreceptor development" BROAD []
is_a: GO:0042461 ! photoreceptor cell development
relationship: part_of GO:0042705 ! ocellus photoreceptor cell differentiation

[Term]
id: GO:0042464
name: dosage compensation, by hypoactivation of X chromosome
namespace: biological_process
def: "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by an inactivation of a proportion of genes on both of the X chromosomes of the XX sex, leading to a decrease, of half, of the levels of gene expression from these chromosomes. An example of this process is found in Caenorhabditis elegans." [GOC:jl, PMID:11102361]
is_a: GO:0007549 ! dosage compensation

[Term]
id: GO:0042465
name: kinesis
namespace: biological_process
def: "The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus." [GOC:jl, ISBN:0192801023]
xref: Wikipedia:Kinesis
is_a: GO:0009605 ! response to external stimulus

[Term]
id: GO:0042466
name: chemokinesis
namespace: biological_process
def: "A response by a motile cell to a soluble chemical that involves an increase or decrease in speed (positive or negative orthokinesis) or of frequency of movement or a change in the frequency or magnitude of turning behavior (klinokinesis)." [GOC:jl, http://cancerweb.ncl.ac.uk/]
xref: Wikipedia:Chemokinesis
is_a: GO:0042465 ! kinesis

[Term]
id: GO:0042467
name: orthokinesis
namespace: biological_process
def: "The movement of a cell or organism in response to a stimulus in which the speed or frequency of movement is increased or decreased." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0042465 ! kinesis

[Term]
id: GO:0042468
name: klinokinesis
namespace: biological_process
def: "The movement of a cell or organism in response to a stimulus in which the frequency or magnitude of turning behavior is altered." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0042465 ! kinesis

[Term]
id: GO:0042469
name: versicolorin reductase activity
namespace: molecular_function
def: "Catalysis of the reduction of versicolorin A to sterigmatocystin." [PMID:1339261]
xref: EC:1.1.-.-
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0042470
name: melanosome
namespace: cellular_component
def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301]
xref: Wikipedia:Melanosome
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0042471
name: ear morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the ear are generated and organized. Morphogenesis pertains to the creation of form. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023]
synonym: "hearing organ morphogenesis" EXACT []
is_a: GO:0048562 ! embryonic organ morphogenesis
relationship: part_of GO:0043583 ! ear development

[Term]
id: GO:0042472
name: inner ear morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the inner ear are generated and organized. Morphogenesis pertains to the creation of form. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively." [GOC:jl, ISBN:0192801023]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0042471 ! ear morphogenesis
relationship: part_of GO:0048839 ! inner ear development

[Term]
id: GO:0042473
name: outer ear morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the outer ear are generated and organized. Morphogenesis pertains to the creation of form. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull." [GOC:jl, ISBN:0192801023]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0042471 ! ear morphogenesis

[Term]
id: GO:0042474
name: middle ear morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of middle ear are generated and organized. Morphogenesis pertains to the creation of form. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window)." [GOC:jl, ISBN:0192801023]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0042471 ! ear morphogenesis

[Term]
id: GO:0042475
name: odontogenesis of dentine-containing tooth
namespace: biological_process
def: "The process whose specific outcome is the progression of a dentine-containing tooth over time, from its formation to the mature structure. A dentine-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and are composed mainly of dentine, a dense calcified substance, covered by a layer of enamel." [GOC:mah, GOC:mtg_sensu, PMID:10333884, PMID:15355794]
synonym: "odontogenesis of dentin-containing tooth" EXACT [GOC:mah]
synonym: "odontogenesis of dentine-containing teeth" EXACT []
synonym: "odontogeny" BROAD []
synonym: "odontosis" BROAD []
synonym: "tooth development" BROAD []
is_a: GO:0042476 ! odontogenesis

[Term]
id: GO:0042476
name: odontogenesis
namespace: biological_process
alt_id: GO:0042477
def: "The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." [GOC:jl, GOC:mah, http://cancerweb.ncl.ac.uk/]
synonym: "odontogenesis of calcareous or chitinous tooth" NARROW []
synonym: "odontogeny" EXACT []
synonym: "odontosis" EXACT []
synonym: "tooth development" EXACT []
xref: Wikipedia:Odontogenesis
is_a: GO:0009887 ! organ morphogenesis

[Term]
id: GO:0042478
name: regulation of eye photoreceptor cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eye photoreceptor development." [GOC:jl]
synonym: "regulation of eye photoreceptor development" EXACT []
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
relationship: regulates GO:0042462 ! eye photoreceptor cell development

[Term]
id: GO:0042479
name: positive regulation of eye photoreceptor cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development." [GOC:jl]
synonym: "activation of eye photoreceptor cell development" NARROW []
synonym: "positive regulation of eye photoreceptor development" EXACT []
synonym: "stimulation of eye photoreceptor cell development" NARROW []
synonym: "up regulation of eye photoreceptor cell development" EXACT []
synonym: "up-regulation of eye photoreceptor cell development" EXACT []
synonym: "upregulation of eye photoreceptor cell development" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0042478 ! regulation of eye photoreceptor cell development
relationship: positively_regulates GO:0042462 ! eye photoreceptor cell development

[Term]
id: GO:0042480
name: negative regulation of eye photoreceptor cell development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of eye photoreceptor development." [GOC:jl]
synonym: "down regulation of eye photoreceptor cell development" EXACT []
synonym: "down-regulation of eye photoreceptor cell development" EXACT []
synonym: "downregulation of eye photoreceptor cell development" EXACT []
synonym: "inhibition of eye photoreceptor cell development" NARROW []
synonym: "negative regulation of eye photoreceptor development" EXACT []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0042478 ! regulation of eye photoreceptor cell development
relationship: negatively_regulates GO:0042462 ! eye photoreceptor cell development

[Term]
id: GO:0042481
name: regulation of odontogenesis
namespace: biological_process
alt_id: GO:0042484
def: "Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl]
synonym: "regulation of odontogenesis of calcareous or chitinous tooth" NARROW []
synonym: "regulation of tooth development" EXACT []
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0042476 ! odontogenesis

[Term]
id: GO:0042482
name: positive regulation of odontogenesis
namespace: biological_process
alt_id: GO:0042485
def: "Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl]
synonym: "activation of odontogenesis" NARROW []
synonym: "positive regulation of odontogenesis of calcareous or chitinous tooth" NARROW []
synonym: "positive regulation of tooth development" EXACT []
synonym: "stimulation of odontogenesis" NARROW []
synonym: "up regulation of odontogenesis" EXACT []
synonym: "up-regulation of odontogenesis" EXACT []
synonym: "upregulation of odontogenesis" EXACT []
is_a: GO:0042481 ! regulation of odontogenesis
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0042476 ! odontogenesis

[Term]
id: GO:0042483
name: negative regulation of odontogenesis
namespace: biological_process
alt_id: GO:0042486
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl]
synonym: "down regulation of odontogenesis" EXACT []
synonym: "down-regulation of odontogenesis" EXACT []
synonym: "downregulation of odontogenesis" EXACT []
synonym: "inhibition of odontogenesis" NARROW []
synonym: "negative regulation of odontogenesis of calcareous or chitinous tooth" NARROW []
synonym: "negative regulation of tooth development" EXACT []
is_a: GO:0042481 ! regulation of odontogenesis
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0042476 ! odontogenesis

[Term]
id: GO:0042487
name: regulation of odontogenesis of dentine-containing tooth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [GOC:jl, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk/, PMID:15355794]
synonym: "regulation of odontogenesis of dentin-containing tooth" EXACT [GOC:mah]
synonym: "regulation of odontogenesis of dentine-containing teeth" EXACT []
is_a: GO:0042481 ! regulation of odontogenesis
relationship: regulates GO:0042475 ! odontogenesis of dentine-containing tooth

[Term]
id: GO:0042488
name: positive regulation of odontogenesis of dentine-containing tooth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [DDB_REF:2530 "DictyBase paper repository", GOC:jl, http://cancerweb.ncl.ac.uk/, PMID:15355794]
synonym: "activation of odontogenesis" BROAD []
synonym: "positive regulation of odontogenesis of dentin-containing tooth" EXACT [GOC:mah]
synonym: "positive regulation of odontogenesis of dentine-containing teeth" EXACT []
synonym: "stimulation of odontogenesis" BROAD []
synonym: "up regulation of odontogenesis" BROAD []
synonym: "up-regulation of odontogenesis" BROAD []
synonym: "upregulation of odontogenesis" BROAD []
is_a: GO:0042482 ! positive regulation of odontogenesis
is_a: GO:0042487 ! regulation of odontogenesis of dentine-containing tooth
relationship: positively_regulates GO:0042475 ! odontogenesis of dentine-containing tooth

[Term]
id: GO:0042489
name: negative regulation of odontogenesis of dentine-containing tooth
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx." [GOC:jl, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk/, PMID:15355794]
synonym: "down regulation of odontogenesis" BROAD []
synonym: "down-regulation of odontogenesis" BROAD []
synonym: "downregulation of odontogenesis" BROAD []
synonym: "inhibition of odontogenesis" BROAD []
synonym: "negative regulation of odontogenesis" BROAD []
synonym: "negative regulation of odontogenesis of dentin-containing tooth" EXACT [GOC:mah]
synonym: "negative regulation of odontogenesis of dentine-containing teeth" EXACT []
is_a: GO:0042483 ! negative regulation of odontogenesis
is_a: GO:0042487 ! regulation of odontogenesis of dentine-containing tooth
relationship: negatively_regulates GO:0042475 ! odontogenesis of dentine-containing tooth

[Term]
id: GO:0042490
name: mechanoreceptor differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0042491
name: auditory receptor cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of an auditory hair cell." [GOC:jl, http://cancerweb.ncl.ac.uk/]
comment: Note that this term refers to the mechanosensory hair cells of the inner ear.
synonym: "auditory hair cell differentiation" EXACT []
is_a: GO:0060113 ! inner ear receptor cell differentiation

[Term]
id: GO:0042492
name: gamma-delta T cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell." [GOC:jl]
synonym: "gamma-delta T lymphocyte differentiation" EXACT []
synonym: "gamma-delta T-cell differentiation" EXACT []
synonym: "gamma-delta T-lymphocyte differentiation" EXACT []
is_a: GO:0030217 ! T cell differentiation
is_a: GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0042493
name: response to drug
namespace: biological_process
alt_id: GO:0017035
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:jl]
subset: goslim_candida
subset: gosubset_prok
synonym: "drug resistance" RELATED []
synonym: "drug susceptibility/resistance" RELATED []
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0042494
name: detection of bacterial lipoprotein
namespace: biological_process
def: "The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs)." [GOC:jl, PMID:12077222]
synonym: "detection of BLP" RELATED []
synonym: "detection of Lpp" RELATED []
synonym: "perception of bacterial lipoprotein" RELATED []
synonym: "perception of BLP" RELATED []
synonym: "perception of Lpp" RELATED []
is_a: GO:0032490 ! detection of molecule of bacterial origin
is_a: GO:0032493 ! response to bacterial lipoprotein
relationship: part_of GO:0016045 ! detection of bacterium

[Term]
id: GO:0042495
name: detection of triacylated bacterial lipoprotein
namespace: biological_process
def: "The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are triacylated lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs)." [GOC:jl, PMID:12077222]
synonym: "perception of triacylated bacterial lipoprotein" RELATED []
is_a: GO:0042494 ! detection of bacterial lipoprotein

[Term]
id: GO:0042496
name: detection of diacylated bacterial lipoprotein
namespace: biological_process
def: "The series of events in which a diacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are diacylated lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs)." [GOC:jl, PMID:12077222]
synonym: "perception of diacylated bacterial lipoprotein" RELATED []
is_a: GO:0042494 ! detection of bacterial lipoprotein

[Term]
id: GO:0042497
name: triacylated lipoprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any conjugated, water-soluble protein in which the nonprotein moiety consists of a three acyl groups." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0008034 ! lipoprotein binding

[Term]
id: GO:0042498
name: diacylated lipoprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any conjugated, water-soluble protein in which the nonprotein moiety consists of a two acyl groups." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0008034 ! lipoprotein binding

[Term]
id: GO:0042499
name: signal peptide peptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein." [PMID:12077416]
comment: This term was made obsolete because it represents a gene product.
synonym: "SPP" EXACT []
xref: EC:3.4.23.-
is_obsolete: true
replaced_by: GO:0042500

[Term]
id: GO:0042500
name: aspartic endopeptidase activity, intramembrane cleaving
namespace: molecular_function
def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within the plasma membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases.
xref: EC:3.4.23.-
is_a: GO:0004190 ! aspartic-type endopeptidase activity

[Term]
id: GO:0042501
name: serine phosphorylation of STAT protein
namespace: biological_process
def: "The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594]
is_a: GO:0018105 ! peptidyl-serine phosphorylation
relationship: part_of GO:0007259 ! JAK-STAT cascade

[Term]
id: GO:0042502
name: tyrosine phosphorylation of Stat2 protein
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594]
is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042503
name: tyrosine phosphorylation of Stat3 protein
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]
is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042504
name: tyrosine phosphorylation of Stat4 protein
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647]
is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042505
name: tyrosine phosphorylation of Stat6 protein
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647]
is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042506
name: tyrosine phosphorylation of Stat5 protein
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647]
is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042507
name: tyrosine phosphorylation of Stat7 protein
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647]
is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042508
name: tyrosine phosphorylation of Stat1 protein
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594]
is_a: GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042509
name: regulation of tyrosine phosphorylation of STAT protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647]
is_a: GO:0046425 ! regulation of JAK-STAT cascade
is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation
relationship: regulates GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042510
name: regulation of tyrosine phosphorylation of Stat1 protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594]
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
relationship: regulates GO:0042508 ! tyrosine phosphorylation of Stat1 protein

[Term]
id: GO:0042511
name: positive regulation of tyrosine phosphorylation of Stat1 protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594]
synonym: "activation of tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat1 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat1 protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of Stat1 protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of Stat1 protein" EXACT []
is_a: GO:0042510 ! regulation of tyrosine phosphorylation of Stat1 protein
is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
relationship: positively_regulates GO:0042508 ! tyrosine phosphorylation of Stat1 protein

[Term]
id: GO:0042512
name: negative regulation of tyrosine phosphorylation of Stat1 protein
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594]
synonym: "down regulation of tyrosine phosphorylation of Stat1 protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of Stat1 protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of Stat1 protein" EXACT []
synonym: "inhibition of tyrosine phosphorylation of Stat1 protein" NARROW []
is_a: GO:0042510 ! regulation of tyrosine phosphorylation of Stat1 protein
is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein
relationship: negatively_regulates GO:0042508 ! tyrosine phosphorylation of Stat1 protein

[Term]
id: GO:0042513
name: regulation of tyrosine phosphorylation of Stat2 protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594]
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
relationship: regulates GO:0042502 ! tyrosine phosphorylation of Stat2 protein

[Term]
id: GO:0042514
name: negative regulation of tyrosine phosphorylation of Stat2 protein
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594]
synonym: "down regulation of tyrosine phosphorylation of Stat2 protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of Stat2 protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of Stat2 protein" EXACT []
synonym: "inhibition of tyrosine phosphorylation of Stat2 protein" NARROW []
is_a: GO:0042513 ! regulation of tyrosine phosphorylation of Stat2 protein
is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein
relationship: negatively_regulates GO:0042502 ! tyrosine phosphorylation of Stat2 protein

[Term]
id: GO:0042515
name: positive regulation of tyrosine phosphorylation of Stat2 protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594]
synonym: "activation of tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat2 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat2 protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of Stat2 protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of Stat2 protein" EXACT []
is_a: GO:0042513 ! regulation of tyrosine phosphorylation of Stat2 protein
is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
relationship: positively_regulates GO:0042502 ! tyrosine phosphorylation of Stat2 protein

[Term]
id: GO:0042516
name: regulation of tyrosine phosphorylation of Stat3 protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
relationship: regulates GO:0042503 ! tyrosine phosphorylation of Stat3 protein

[Term]
id: GO:0042517
name: positive regulation of tyrosine phosphorylation of Stat3 protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]
synonym: "activation of tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat3 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat3 protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of Stat3 protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of Stat3 protein" EXACT []
is_a: GO:0042516 ! regulation of tyrosine phosphorylation of Stat3 protein
is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
relationship: positively_regulates GO:0042503 ! tyrosine phosphorylation of Stat3 protein

[Term]
id: GO:0042518
name: negative regulation of tyrosine phosphorylation of Stat3 protein
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]
synonym: "down regulation of tyrosine phosphorylation of Stat3 protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of Stat3 protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of Stat3 protein" EXACT []
synonym: "inhibition of tyrosine phosphorylation of Stat3 protein" NARROW []
is_a: GO:0042516 ! regulation of tyrosine phosphorylation of Stat3 protein
is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein
relationship: negatively_regulates GO:0042503 ! tyrosine phosphorylation of Stat3 protein

[Term]
id: GO:0042519
name: regulation of tyrosine phosphorylation of Stat4 protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647]
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
relationship: regulates GO:0042504 ! tyrosine phosphorylation of Stat4 protein

[Term]
id: GO:0042520
name: positive regulation of tyrosine phosphorylation of Stat4 protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647]
synonym: "activation of tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat4 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat4 protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of Stat4 protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of Stat4 protein" EXACT []
is_a: GO:0042519 ! regulation of tyrosine phosphorylation of Stat4 protein
is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
relationship: positively_regulates GO:0042504 ! tyrosine phosphorylation of Stat4 protein

[Term]
id: GO:0042521
name: negative regulation of tyrosine phosphorylation of Stat4 protein
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647]
synonym: "down regulation of tyrosine phosphorylation of Stat4 protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of Stat4 protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of Stat4 protein" EXACT []
synonym: "inhibition of tyrosine phosphorylation of Stat4 protein" NARROW []
is_a: GO:0042519 ! regulation of tyrosine phosphorylation of Stat4 protein
is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein
relationship: negatively_regulates GO:0042504 ! tyrosine phosphorylation of Stat4 protein

[Term]
id: GO:0042522
name: regulation of tyrosine phosphorylation of Stat5 protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647]
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
relationship: regulates GO:0042506 ! tyrosine phosphorylation of Stat5 protein

[Term]
id: GO:0042523
name: positive regulation of tyrosine phosphorylation of Stat5 protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647]
synonym: "activation of tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat5 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat5 protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of Stat5 protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of Stat5 protein" EXACT []
is_a: GO:0042522 ! regulation of tyrosine phosphorylation of Stat5 protein
is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
relationship: positively_regulates GO:0042506 ! tyrosine phosphorylation of Stat5 protein

[Term]
id: GO:0042524
name: negative regulation of tyrosine phosphorylation of Stat5 protein
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647]
synonym: "down regulation of tyrosine phosphorylation of Stat5 protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of Stat5 protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of Stat5 protein" EXACT []
synonym: "inhibition of tyrosine phosphorylation of Stat5 protein" NARROW []
is_a: GO:0042522 ! regulation of tyrosine phosphorylation of Stat5 protein
is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein
relationship: negatively_regulates GO:0042506 ! tyrosine phosphorylation of Stat5 protein

[Term]
id: GO:0042525
name: regulation of tyrosine phosphorylation of Stat6 protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647]
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
relationship: regulates GO:0042505 ! tyrosine phosphorylation of Stat6 protein

[Term]
id: GO:0042526
name: positive regulation of tyrosine phosphorylation of Stat6 protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647]
synonym: "activation of tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat6 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat6 protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of Stat6 protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of Stat6 protein" EXACT []
is_a: GO:0042525 ! regulation of tyrosine phosphorylation of Stat6 protein
is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
relationship: positively_regulates GO:0042505 ! tyrosine phosphorylation of Stat6 protein

[Term]
id: GO:0042527
name: negative regulation of tyrosine phosphorylation of Stat6 protein
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647]
synonym: "down regulation of tyrosine phosphorylation of Stat6 protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of Stat6 protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of Stat6 protein" EXACT []
synonym: "inhibition of tyrosine phosphorylation of Stat6 protein" NARROW []
is_a: GO:0042525 ! regulation of tyrosine phosphorylation of Stat6 protein
is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein
relationship: negatively_regulates GO:0042505 ! tyrosine phosphorylation of Stat6 protein

[Term]
id: GO:0042528
name: regulation of tyrosine phosphorylation of Stat7 protein
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647]
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
relationship: regulates GO:0042507 ! tyrosine phosphorylation of Stat7 protein

[Term]
id: GO:0042529
name: positive regulation of tyrosine phosphorylation of Stat7 protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647]
synonym: "activation of tyrosine phosphorylation of Stat7 protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of Stat7 protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of Stat7 protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of Stat7 protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of Stat7 protein" EXACT []
is_a: GO:0042528 ! regulation of tyrosine phosphorylation of Stat7 protein
is_a: GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
relationship: positively_regulates GO:0042507 ! tyrosine phosphorylation of Stat7 protein

[Term]
id: GO:0042530
name: negative regulation of tyrosine phosphorylation of Stat7 protein
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647]
synonym: "down regulation of tyrosine phosphorylation of Stat7 protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of Stat7 protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of Stat7 protein" EXACT []
synonym: "inhibition of tyrosine phosphorylation of Stat7 protein" NARROW []
is_a: GO:0042528 ! regulation of tyrosine phosphorylation of Stat7 protein
is_a: GO:0042532 ! negative regulation of tyrosine phosphorylation of STAT protein
relationship: negatively_regulates GO:0042507 ! tyrosine phosphorylation of Stat7 protein

[Term]
id: GO:0042531
name: positive regulation of tyrosine phosphorylation of STAT protein
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647]
synonym: "activation of tyrosine phosphorylation of STAT protein" NARROW []
synonym: "stimulation of tyrosine phosphorylation of STAT protein" NARROW []
synonym: "up regulation of tyrosine phosphorylation of STAT protein" EXACT []
synonym: "up-regulation of tyrosine phosphorylation of STAT protein" EXACT []
synonym: "upregulation of tyrosine phosphorylation of STAT protein" EXACT []
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
is_a: GO:0046427 ! positive regulation of JAK-STAT cascade
is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
relationship: positively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042532
name: negative regulation of tyrosine phosphorylation of STAT protein
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647]
synonym: "down regulation of tyrosine phosphorylation of STAT protein" EXACT []
synonym: "down-regulation of tyrosine phosphorylation of STAT protein" EXACT []
synonym: "downregulation of tyrosine phosphorylation of STAT protein" EXACT []
synonym: "inhibition of tyrosine phosphorylation of STAT protein" NARROW []
is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein
is_a: GO:0046426 ! negative regulation of JAK-STAT cascade
is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation
relationship: negatively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein

[Term]
id: GO:0042533
name: tumor necrosis factor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "TNF alpha biosynthesis" EXACT []
synonym: "TNF alpha biosynthetic process" EXACT []
synonym: "TNF biosynthesis" EXACT []
synonym: "TNF biosynthetic process" EXACT []
synonym: "TNF-alpha biosynthesis" EXACT []
synonym: "TNF-alpha biosynthetic process" EXACT []
synonym: "Tumor Necrosis Factor alpha biosynthesis" EXACT []
synonym: "Tumor Necrosis Factor alpha biosynthetic process" EXACT []
synonym: "tumor necrosis factor anabolism" EXACT []
synonym: "tumor necrosis factor biosynthesis" EXACT []
synonym: "tumor necrosis factor formation" EXACT []
synonym: "tumor necrosis factor synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032640 ! tumor necrosis factor production

[Term]
id: GO:0042534
name: regulation of tumor necrosis factor biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "regulation of TNF alpha biosynthesis" EXACT []
synonym: "regulation of TNF alpha biosynthetic process" EXACT []
synonym: "regulation of TNF biosynthesis" EXACT []
synonym: "regulation of TNF biosynthetic process" EXACT []
synonym: "regulation of TNF-alpha biosynthesis" EXACT []
synonym: "regulation of TNF-alpha biosynthetic process" EXACT []
synonym: "regulation of tumor necrosis factor anabolism" EXACT []
synonym: "regulation of tumor necrosis factor biosynthesis" EXACT []
synonym: "regulation of tumor necrosis factor formation" EXACT []
synonym: "regulation of tumor necrosis factor synthesis" EXACT []
synonym: "regulation of tumor necrosis factor-alpha biosynthesis" EXACT []
synonym: "regulation of tumor necrosis factor-alpha biosynthetic process" EXACT []
is_a: GO:0032680 ! regulation of tumor necrosis factor production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042533 ! tumor necrosis factor biosynthetic process

[Term]
id: GO:0042535
name: positive regulation of tumor necrosis factor biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "activation of tumor necrosis factor biosynthetic process" NARROW []
synonym: "positive regulation of TNF alpha biosynthesis" EXACT []
synonym: "positive regulation of TNF alpha biosynthetic process" EXACT []
synonym: "positive regulation of TNF biosynthesis" EXACT []
synonym: "positive regulation of TNF biosynthetic process" EXACT []
synonym: "positive regulation of TNF-alpha biosynthesis" EXACT []
synonym: "positive regulation of TNF-alpha biosynthetic process" EXACT []
synonym: "positive regulation of tumor necrosis factor anabolism" EXACT []
synonym: "positive regulation of tumor necrosis factor biosynthesis" EXACT []
synonym: "positive regulation of tumor necrosis factor formation" EXACT []
synonym: "positive regulation of tumor necrosis factor synthesis" EXACT []
synonym: "positive regulation of tumor necrosis factor-alpha biosynthesis" EXACT []
synonym: "positive regulation of tumor necrosis factor-alpha biosynthetic process" EXACT []
synonym: "stimulation of tumor necrosis factor biosynthetic process" NARROW []
synonym: "up regulation of tumor necrosis factor biosynthetic process" EXACT []
synonym: "up-regulation of tumor necrosis factor biosynthetic process" EXACT []
synonym: "upregulation of tumor necrosis factor biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0042534 ! regulation of tumor necrosis factor biosynthetic process
relationship: positively_regulates GO:0042533 ! tumor necrosis factor biosynthetic process

[Term]
id: GO:0042536
name: negative regulation of tumor necrosis factor biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884]
comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
synonym: "down regulation of tumor necrosis factor biosynthetic process" EXACT []
synonym: "down-regulation of tumor necrosis factor biosynthetic process" EXACT []
synonym: "downregulation of tumor necrosis factor biosynthetic process" EXACT []
synonym: "inhibition of tumor necrosis factor biosynthetic process" NARROW []
synonym: "negative regulation of TNF alpha biosynthesis" EXACT []
synonym: "negative regulation of TNF alpha biosynthetic process" EXACT []
synonym: "negative regulation of TNF biosynthesis" EXACT []
synonym: "negative regulation of TNF biosynthetic process" EXACT []
synonym: "negative regulation of TNF-alpha biosynthesis" EXACT []
synonym: "negative regulation of TNF-alpha biosynthetic process" EXACT []
synonym: "negative regulation of tumor necrosis factor anabolism" EXACT []
synonym: "negative regulation of tumor necrosis factor biosynthesis" EXACT []
synonym: "negative regulation of tumor necrosis factor formation" EXACT []
synonym: "negative regulation of tumor necrosis factor synthesis" EXACT []
synonym: "negative regulation of tumor necrosis factor-alpha biosynthesis" EXACT []
synonym: "negative regulation of tumor necrosis factor-alpha biosynthetic process" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0042534 ! regulation of tumor necrosis factor biosynthetic process
relationship: negatively_regulates GO:0042533 ! tumor necrosis factor biosynthetic process

[Term]
id: GO:0042537
name: benzene and derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "benzene and derivative metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006805 ! xenobiotic metabolic process

[Term]
id: GO:0042538
name: hyperosmotic salinity response
namespace: biological_process
def: "A change in state or activity of a cell or an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]
synonym: "response to hyperosmotic salt stress" EXACT []
synonym: "salt tolerance" RELATED []
is_a: GO:0006972 ! hyperosmotic response
is_a: GO:0009651 ! response to salt stress

[Term]
id: GO:0042539
name: hypotonic salinity response
namespace: biological_process
def: "A change in state or activity of a cell or an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]
synonym: "response to hypotonic salt stress" EXACT []
is_a: GO:0006971 ! hypotonic response
is_a: GO:0009651 ! response to salt stress

[Term]
id: GO:0042540
name: hemoglobin catabolic process
namespace: biological_process
alt_id: GO:0020029
def: "The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids." [GOC:jl, GOC:mb, http://cancerweb.ncl.ac.uk/]
comment: Note that 'hydrolysis' is actually a reaction rather than a process. The synonym 'hemoglobin hydrolysis' was the text string associated with the secondary ID GO:0020029, which was retained because its definition did describe a process.
synonym: "haemoglobin catabolic process" EXACT []
synonym: "haemoglobin catabolism" EXACT []
synonym: "haemoglobin hydrolysis" NARROW []
synonym: "hemoglobin breakdown" EXACT []
synonym: "hemoglobin catabolism" EXACT []
synonym: "hemoglobin degradation" EXACT []
synonym: "hemoglobin hydrolysis" NARROW []
is_a: GO:0020027 ! hemoglobin metabolic process
is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process

[Term]
id: GO:0042541
name: hemoglobin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:jl, http://cancerweb.ncl.ac.uk/]
synonym: "haemoglobin biosynthesis" EXACT []
synonym: "haemoglobin biosynthetic process" EXACT []
synonym: "hemoglobin anabolism" EXACT []
synonym: "hemoglobin biosynthesis" EXACT []
synonym: "hemoglobin formation" EXACT []
synonym: "hemoglobin synthesis" EXACT []
is_a: GO:0020027 ! hemoglobin metabolic process
is_a: GO:0034645 ! cellular macromolecule biosynthetic process

[Term]
id: GO:0042542
name: response to hydrogen peroxide
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]
subset: gosubset_prok
is_a: GO:0000302 ! response to reactive oxygen species

[Term]
id: GO:0042543
name: protein amino acid N-linked glycosylation via arginine
namespace: biological_process
def: "The posttranslational glycosylation of protein via peptidyl-arginine, omega-N-glycosyl-L-arginine." [RESID:AA0327]
subset: gosubset_prok
xref: RESID:AA0327
is_a: GO:0006487 ! protein amino acid N-linked glycosylation
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0042544
name: melibiose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "melibiose anabolism" EXACT []
synonym: "melibiose biosynthesis" EXACT []
synonym: "melibiose formation" EXACT []
synonym: "melibiose synthesis" EXACT []
is_a: GO:0005994 ! melibiose metabolic process
is_a: GO:0046351 ! disaccharide biosynthetic process

[Term]
id: GO:0042545
name: cell wall modification
namespace: biological_process
def: "The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly." [GOC:jl]
subset: gosubset_prok
is_a: GO:0071555 ! cell wall organization

[Term]
id: GO:0042546
name: cell wall biogenesis
namespace: biological_process
def: "The process by which a cell wall is synthesized, aggregates, and bonds together. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mah, GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cell wall assembly" NARROW []
is_a: GO:0044085 ! cellular component biogenesis
is_a: GO:0070882 ! cellular cell wall organization or biogenesis

[Term]
id: GO:0042547
name: cell wall modification during multidimensional cell growth
namespace: biological_process
def: "The series of events that occur during cell growth that result in chemical or structural changes to existing cell walls." [GOC:jl]
subset: gosubset_prok
synonym: "cell wall modification during cell expansion" EXACT []
is_a: GO:0042545 ! cell wall modification
relationship: part_of GO:0009825 ! multidimensional cell growth

[Term]
id: GO:0042548
name: regulation of photosynthesis, light reaction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the light-dependent reaction of photosynthesis." [GOC:jl]
is_a: GO:0010109 ! regulation of photosynthesis
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
relationship: regulates GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0042549
name: photosystem II stabilization
namespace: biological_process
def: "The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis." [GOC:go_curators]
is_a: GO:0042548 ! regulation of photosynthesis, light reaction

[Term]
id: GO:0042550
name: photosystem I stabilization
namespace: biological_process
def: "The stabilization of the photosystem I protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis." [GOC:go_curators]
is_a: GO:0042548 ! regulation of photosynthesis, light reaction

[Term]
id: GO:0042551
name: neuron maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state." [GOC:dph, GOC:jl]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0048666 ! neuron development

[Term]
id: GO:0042552
name: myelination
namespace: biological_process
def: "The process by which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GOC:dgh, GOC:mah]
xref: Wikipedia:Myelin
is_a: GO:0008366 ! axon ensheathment

[Term]
id: GO:0042554
name: superoxide anion generation
namespace: biological_process
def: "The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750]
subset: gosubset_prok
synonym: "superoxide release" EXACT [GOC:hjd, GOC:mah]
is_a: GO:0006801 ! superoxide metabolic process

[Term]
id: GO:0042555
name: MCM complex
namespace: cellular_component
def: "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]
synonym: "mini-chromosome maintenance complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0042556
name: eukaryotic elongation factor-2 kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175]
synonym: "eEF-2 kinase regulator" EXACT []
xref: EC:2.7.1.-
is_a: GO:0019887 ! protein kinase regulator activity

[Term]
id: GO:0042557
name: eukaryotic elongation factor-2 kinase activator activity
namespace: molecular_function
def: "Increases the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175]
synonym: "eEF-2 kinase activator" EXACT []
xref: EC:2.7.1.-
is_a: GO:0030295 ! protein kinase activator activity
is_a: GO:0042556 ! eukaryotic elongation factor-2 kinase regulator activity

[Term]
id: GO:0042558
name: pteridine and derivative metabolic process
namespace: biological_process
alt_id: GO:0019721
def: "The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pteridine and derivative metabolism" EXACT []
synonym: "pterin metabolic process" EXACT []
synonym: "pterin metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0042559
name: pteridine and derivative biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pteridine and derivative anabolism" EXACT []
synonym: "pteridine and derivative biosynthesis" EXACT []
synonym: "pteridine and derivative formation" EXACT []
synonym: "pteridine and derivative synthesis" EXACT []
synonym: "pterin biosynthesis" EXACT []
synonym: "pterin biosynthetic process" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042558 ! pteridine and derivative metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process

[Term]
id: GO:0042560
name: pteridine and derivative catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pteridine and derivative breakdown" EXACT []
synonym: "pteridine and derivative catabolism" EXACT []
synonym: "pteridine and derivative degradation" EXACT []
synonym: "pterin catabolic process" EXACT []
synonym: "pterin catabolism" EXACT []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042558 ! pteridine and derivative metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0042561
name: alpha-amyrin synthase activity
namespace: molecular_function
def: "Catalysis of the cyclization and rearrangement of 2,3-oxidosqualene into alpha-amyrin." [GOC:jl, PMID:10848960]
xref: MetaCyc:PWY-5377
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0042562
name: hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: goslim_pir
is_a: GO:0005488 ! binding

[Term]
id: GO:0042563
name: importin alpha-subunit nuclear export complex
namespace: cellular_component
def: "A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha-subunit/CAS/Ran, and which functions to shuttle the importin alpha-subunit out of the nucleus through the nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134]
is_a: GO:0031074 ! nucleocytoplasmic shuttling complex

[Term]
id: GO:0042564
name: NLS-dependent protein nuclear import complex
namespace: cellular_component
def: "A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha and beta-subunits and any protein which has a nuclear localization sequence (NLS). The complex acts to import proteins with an NLS into the nucleus through a nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134]
is_a: GO:0031074 ! nucleocytoplasmic shuttling complex

[Term]
id: GO:0042565
name: RNA nuclear export complex
namespace: cellular_component
def: "A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore." [GOC:jl, PMID:9323123]
is_a: GO:0031074 ! nucleocytoplasmic shuttling complex

[Term]
id: GO:0042566
name: hydrogenosome
namespace: cellular_component
def: "A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation." [GOC:jl, PMID:11197234, PMID:11293569]
subset: goslim_pir
xref: Wikipedia:Hydrogenosome
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0042567
name: insulin-like growth factor ternary complex
namespace: cellular_component
def: "A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development." [GOC:jl, PMID:12239079]
synonym: "IGF ternary complex" EXACT []
is_a: GO:0016942 ! insulin-like growth factor binding protein complex

[Term]
id: GO:0042568
name: insulin-like growth factor binary complex
namespace: cellular_component
def: "A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development." [GOC:jl, PMID:12239079]
synonym: "IGF binary complex" EXACT []
is_a: GO:0016942 ! insulin-like growth factor binding protein complex

[Term]
id: GO:0042571
name: immunoglobulin complex, circulating
namespace: cellular_component
def: "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "antibody" EXACT [GOC:add]
xref: Wikipedia:Antibody
is_a: GO:0019814 ! immunoglobulin complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0042572
name: retinol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "retinol metabolism" EXACT []
synonym: "vitamin A1 alcohol metabolic process" EXACT []
synonym: "vitamin A1 alcohol metabolism" EXACT []
synonym: "vitamin A1 metabolic process" EXACT []
synonym: "vitamin A1 metabolism" EXACT []
xref: Wikipedia:Retinol
is_a: GO:0001523 ! retinoid metabolic process
is_a: GO:0006776 ! vitamin A metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process

[Term]
id: GO:0042573
name: retinoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "retinoic acid metabolism" EXACT []
synonym: "vitamin A1 acid metabolic process" EXACT []
synonym: "vitamin A1 acid metabolism" EXACT []
is_a: GO:0001523 ! retinoid metabolic process
is_a: GO:0006776 ! vitamin A metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process

[Term]
id: GO:0042574
name: retinal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "retinal metabolism" EXACT []
synonym: "retinaldehyde metabolic process" EXACT []
synonym: "retinaldehyde metabolism" EXACT []
is_a: GO:0001523 ! retinoid metabolic process
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0006776 ! vitamin A metabolic process
is_a: GO:0043288 ! apocarotenoid metabolic process

[Term]
id: GO:0042575
name: DNA polymerase complex
namespace: cellular_component
def: "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." [GOC:jl, http://cancerweb.ncl.ac.uk/, PMID:12045093]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0042576
name: aspartyl aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate." [EC:3.4.11.21]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
xref: EC:3.4.11.21
xref: MetaCyc:3.4.11.21-RXN
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0042577
name: lipid phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [GOC:jl]
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0042578
name: phosphoric ester hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]
subset: gosubset_prok
xref: EC:3.1.-.-
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0042579
name: microbody
namespace: cellular_component
def: "Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
xref: Wikipedia:Microbody
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0042580
name: mannosome
namespace: cellular_component
def: "A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction." [GOC:jl, PMID:11912051, PMID:9799531]
is_a: GO:0005777 ! peroxisome

[Term]
id: GO:0042581
name: specific granule
namespace: cellular_component
def: "Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:jl, http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:7334549]
synonym: "secondary granule" EXACT []
xref: Wikipedia:Specific_granule
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042582
name: azurophil granule
namespace: cellular_component
def: "Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:jl, http://cancerweb.ncl.ac.uk/]
synonym: "primary granule" EXACT []
is_a: GO:0005766 ! primary lysosome
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042583
name: chromaffin granule
namespace: cellular_component
def: "Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042584
name: chromaffin granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042583 ! chromaffin granule

[Term]
id: GO:0042585
name: germinal vesicle
namespace: cellular_component
def: "The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity." [GOC:jl, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk/]
synonym: "primary oocyte nucleus" EXACT []
is_a: GO:0001674 ! female germ cell nucleus

[Term]
id: GO:0042586
name: peptide deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide." [EC:3.5.1.88, GOC:jl]
subset: gosubset_prok
synonym: "formyl-L-methionyl peptide amidohydrolase activity" EXACT [EC:3.5.1.88]
synonym: "PDF activity" EXACT [EC:3.5.1.88]
synonym: "polypeptide deformylase activity" EXACT [EC:3.5.1.88]
xref: EC:3.5.1.88
xref: MetaCyc:3.5.1.88-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0042587
name: glycogen granule
namespace: cellular_component
def: "Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface." [GOC:jl, http://148.216.10.83/cellbio/the_mi19.gif, PMID:12179957]
synonym: "glycogen particle" EXACT []
xref: NIF_Subcellular:sao1081228141
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0042588
name: zymogen granule
namespace: cellular_component
def: "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042589
name: zymogen granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a zymogen granule." [GOC:jl]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0042588 ! zymogen granule

[Term]
id: GO:0042590
name: antigen processing and presentation of exogenous peptide antigen via MHC class I
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
synonym: "antigen presentation, exogenous antigen via major histocompatibility complex class I" EXACT []
synonym: "antigen presentation, exogenous antigen via MHC class I" EXACT []
synonym: "cross presentation" BROAD []
synonym: "cross priming" BROAD []
synonym: "cross-presentation" BROAD []
synonym: "cross-priming" BROAD []
synonym: "exogenous peptide antigen processing and presentation via MHC class I" EXACT []
is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I
is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen

[Term]
id: GO:0042592
name: homeostatic process
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal equilibrium." [GOC:jl, ISBN:0395825172]
subset: gosubset_prok
synonym: "homeostasis" RELATED []
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0042593
name: glucose homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of glucose within an organism or cell." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0033500 ! carbohydrate homeostasis

[Term]
id: GO:0042594
name: response to starvation
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006950 ! response to stress
is_a: GO:0031667 ! response to nutrient levels

[Term]
id: GO:0042595
name: behavioral response to starvation
namespace: biological_process
def: "A change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators]
synonym: "behavioural response to starvation" EXACT []
is_a: GO:0042594 ! response to starvation

[Term]
id: GO:0042596
name: fear response
namespace: biological_process
alt_id: GO:0001663
def: "The response of an organism to a perceived external threat." [GOC:go_curators]
synonym: "physiological fear response" EXACT []
is_a: GO:0033555 ! multicellular organismal response to stress

[Term]
id: GO:0042597
name: periplasmic space
namespace: cellular_component
alt_id: GO:0005620
def: "The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or inner membrane and cell wall (Fungi)." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "periplasm" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0042598
name: vesicular fraction
namespace: cellular_component
def: "Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized." [GOC:jl]
comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell.
subset: gosubset_prok
is_a: GO:0005624 ! membrane fraction

[Term]
id: GO:0042599
name: lamellar body
namespace: cellular_component
def: "A membrane-bounded organelle, specialized for the storage and secretion various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome." [GOC:jl, PMID:12243725]
synonym: "keratinosome" EXACT []
synonym: "lamellar granule" EXACT []
synonym: "membrane-coating granule" EXACT []
synonym: "Odland body" EXACT []
xref: NIF_Subcellular:sao1379604862
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042600
name: chorion
namespace: cellular_component
def: "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
comment: Note that this term does not refer to the extraembryonic membrane surrounding the embryo of amniote vertebrates as this is an anatomical structure and is therefore not covered by GO.
subset: goslim_pir
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0042601
name: endospore-forming forespore
namespace: cellular_component
def: "Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions." [GOC:jl, GOC:mtg_sensu, ISBN:0697286029]
subset: gosubset_prok
is_a: GO:0042763 ! intracellular immature spore

[Term]
id: GO:0042602
name: flavin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + H+." [EC:1.5.1.30]
subset: gosubset_prok
synonym: "FMN reductase (NADPH) activity" EXACT [EC:1.5.1.30]
synonym: "NADPH dehydrogenase (flavin) activity" EXACT [EC:1.5.1.30]
synonym: "NADPH-dependent FMN reductase activity" EXACT [EC:1.5.1.30]
synonym: "NADPH-flavin oxidoreductase activity" EXACT []
synonym: "NADPH-flavin reductase activity" EXACT [EC:1.5.1.30]
synonym: "NADPH-FMN reductase activity" EXACT [EC:1.5.1.30]
synonym: "NADPH-specific FMN reductase activity" EXACT [EC:1.5.1.30]
synonym: "NADPH2 dehydrogenase (flavin)" EXACT [EC:1.5.1.30]
synonym: "NADPH2:riboflavin oxidoreductase activity" EXACT [EC:1.5.1.30]
synonym: "NADPH:flavin oxidoreductase activity" EXACT [EC:1.5.1.30]
synonym: "NADPH:riboflavin oxidoreductase activity" EXACT [EC:1.5.1.30]
synonym: "reduced-riboflavin:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.30]
synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.5.1.30]
synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.30]
synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.30]
xref: EC:1.5.1.30
xref: MetaCyc:NADPH-DEHYDROGENASE-FLAVIN-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0042603
name: capsule
namespace: cellular_component
alt_id: GO:0030113
alt_id: GO:0042604
def: "A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and can not be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherance, and resistance to dessication." [GOC:mlg]
subset: gosubset_prok
xref: Wikipedia:Capsule_(microbiology)
is_a: GO:0030112 ! glycocalyx

[Term]
id: GO:0042605
name: peptide antigen binding
namespace: molecular_function
alt_id: GO:0042606
alt_id: GO:0042607
def: "Interacting selectively and non-covalently with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell." [GOC:jl]
comment: Note that this term can be used to describe binding to the peptide expressed by an MHC molecule.
synonym: "endogenous peptide antigen binding" NARROW []
synonym: "exogenous peptide antigen binding" NARROW []
is_a: GO:0003823 ! antigen binding
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0042608
name: T cell receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells." [GOC:jl, http://cancerweb.ncl.ac.uk/]
synonym: "T lymphocyte receptor binding" EXACT []
synonym: "T-cell receptor binding" EXACT []
synonym: "T-lymphocyte receptor binding" EXACT []
synonym: "TCR binding" EXACT []
is_a: GO:0005102 ! receptor binding
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0042609
name: CD4 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages." [GOC:jl, MeSH:D015704]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0042610
name: CD8 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes." [GOC:jl, MeSH:D016827]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0042611
name: MHC protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0781735149 "Fundamental Immunology", PMID:15928678, PMID:16153240]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0042612
name: MHC class I protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules." [GOC:add, GOC:jl, ISBN:0120781859, ISBN:0781735149 "Fundamental Immunology"]
comment: See also the cellular component term 'MHC class I peptide loading complex ; GO:0042824'.
is_a: GO:0042611 ! MHC protein complex

[Term]
id: GO:0042613
name: MHC class II protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678]
is_a: GO:0042611 ! MHC protein complex

[Term]
id: GO:0042614
name: CD70 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CD70, a receptor found on the surface of most activated B cells and some activated T cells." [GOC:jl, ISBN:0120781859]
synonym: "CD27 receptor activity" RELATED []
synonym: "CD27L binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0042615
name: CD154 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with CD154, a receptor found on the surface of some activated lymphocytes." [GOC:jl, ISBN:0120781859]
synonym: "CD40 receptor activity" RELATED []
synonym: "CD40L binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0042616
name: paclitaxel metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving paclitaxel, an alkaloid compound used as an anticancer treatment." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "paclitaxel metabolism" EXACT []
synonym: "taxol metabolic process" NARROW []
synonym: "taxol metabolism" NARROW []
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0042617
name: paclitaxel biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of paclitaxel, an alkaloid compound used as an anticancer treatment." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "paclitaxel anabolism" EXACT []
synonym: "paclitaxel biosynthesis" EXACT []
synonym: "paclitaxel formation" EXACT []
synonym: "paclitaxel synthesis" EXACT []
synonym: "taxol biosynthesis" NARROW []
synonym: "taxol biosynthetic process" NARROW []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0016102 ! diterpenoid biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042616 ! paclitaxel metabolic process

[Term]
id: GO:0042618
name: poly-hydroxybutyrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, http://biotech.icmb.utexas.edu/search/dict-search.html]
subset: gosubset_prok
synonym: "PHB metabolic process" EXACT []
synonym: "PHB metabolism" EXACT []
synonym: "poly-hydroxybutyrate metabolism" EXACT []
is_a: GO:0019605 ! butyrate metabolic process

[Term]
id: GO:0042619
name: poly-hydroxybutyrate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, http://biotech.icmb.utexas.edu/search/dict-search.html]
subset: gosubset_prok
synonym: "PHB biosynthesis" EXACT []
synonym: "PHB biosynthetic process" EXACT []
synonym: "poly-hydroxybutyrate anabolism" EXACT []
synonym: "poly-hydroxybutyrate biosynthesis" EXACT []
synonym: "poly-hydroxybutyrate formation" EXACT []
synonym: "poly-hydroxybutyrate synthesis" EXACT []
is_a: GO:0042618 ! poly-hydroxybutyrate metabolic process
is_a: GO:0046358 ! butyrate biosynthetic process

[Term]
id: GO:0042620
name: poly(3-hydroxyalkanoate) metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580]
subset: goslim_pir
subset: gosubset_prok
synonym: "PHA metabolic process" BROAD []
synonym: "PHA metabolism" BROAD []
synonym: "poly(3-hydroxyalkanoate) metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0042621
name: poly(3-hydroxyalkanoate) biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580]
subset: gosubset_prok
synonym: "PHA biosynthesis" BROAD []
synonym: "PHA biosynthetic process" BROAD []
synonym: "poly(3-hydroxyalkanoate) anabolism" EXACT []
synonym: "poly(3-hydroxyalkanoate) biosynthesis" EXACT []
synonym: "poly(3-hydroxyalkanoate) formation" EXACT []
synonym: "poly(3-hydroxyalkanoate) synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
is_a: GO:0042620 ! poly(3-hydroxyalkanoate) metabolic process

[Term]
id: GO:0042622
name: photoreceptor outer segment membrane
namespace: cellular_component
def: "The membrane surrounding the outer segment of a vertebrate photoreceptor." [GOC:jl]
is_a: GO:0016020 ! membrane
is_a: GO:0044441 ! cilium part
relationship: part_of GO:0001750 ! photoreceptor outer segment

[Term]
id: GO:0042623
name: ATPase activity, coupled
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (polypeptide-unfolding)" NARROW [EC:3.6.4.9]
synonym: "chaperonin" RELATED [EC:3.6.4.9]
synonym: "chaperonin ATPase activity" RELATED []
synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED []
synonym: "nucleoplasmin ATPase activity" RELATED []
synonym: "peroxisome-assembly ATPase activity" RELATED []
is_a: GO:0016887 ! ATPase activity

[Term]
id: GO:0042624
name: ATPase activity, uncoupled
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; not directly coupled to any other reaction." [EC:3.6.1.3]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "adenylpyrophosphatase activity" RELATED [EC:3.6.1.3]
xref: EC:3.6.1.3
xref: MetaCyc:ADENOSINETRIPHOSPHATASE-RXN
is_a: GO:0016887 ! ATPase activity

[Term]
id: GO:0042625
name: ATPase activity, coupled to transmembrane movement of ions
namespace: molecular_function
def: "Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate." [EC:3.6.1.3, GOC:def, GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015075 ! ion transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0042626
name: ATPase activity, coupled to transmembrane movement of substances
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ABC transporter" NARROW []
synonym: "ABC-type efflux permease activity" NARROW []
synonym: "ABC-type efflux porter activity" NARROW []
synonym: "ABC-type uptake permease activity" NARROW []
synonym: "ATP binding cassette transporter" NARROW []
synonym: "ATP-binding cassette (ABC) transporter activity" NARROW []
synonym: "ATP-binding cassette transporter" NARROW []
synonym: "mating pheromone exporter" NARROW []
xref: Reactome:78033 "ATPase activity, coupled to transmembrane movement of substances"
is_a: GO:0015405 ! P-P-bond-hydrolysis-driven transmembrane transporter activity
is_a: GO:0016820 ! hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
is_a: GO:0043492 ! ATPase activity, coupled to movement of substances

[Term]
id: GO:0042627
name: chylomicron
namespace: cellular_component
def: "A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues." [GOC:jl, GOC:rl, http://biotech.icmb.utexas.edu/search/dict-search.html, http://cancerweb.ncl.ac.uk/]
xref: Wikipedia:Chylomicron
is_a: GO:0034358 ! plasma lipoprotein particle

[Term]
id: GO:0042628
name: mating plug formation
namespace: biological_process
def: "The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males." [GOC:jl, http://www.wildcru.org/glossary/glossary.htm, http://www.wormatlas.org/glossaries/cglossary.htm, PMID:11267893]
synonym: "copulatory plug biosynthesis" EXACT []
synonym: "copulatory plug deposition" EXACT []
synonym: "copulatory plug formation" EXACT []
synonym: "mating plug deposition" EXACT []
is_a: GO:0045297 ! post-mating behavior
relationship: part_of GO:0007320 ! insemination

[Term]
id: GO:0042629
name: mast cell granule
namespace: cellular_component
def: "Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase." [GOC:jl, http://cancerweb.ncl.ac.uk/, http://www.ijp-online.com/archives/1969/001/02/r0000-0000tc.htm, PMID:12360215]
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0042630
name: behavioral response to water deprivation
namespace: biological_process
def: "A change in the behavior of an organism as a result of deprivation of water." [GOC:jl]
synonym: "behavioral response to drought" EXACT []
synonym: "behavioral response to thirst" EXACT []
synonym: "behavioural response to water deprivation" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0009414 ! response to water deprivation

[Term]
id: GO:0042631
name: cellular response to water deprivation
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water." [GOC:go_curators]
synonym: "cellular response to drought" EXACT []
is_a: GO:0009414 ! response to water deprivation
is_a: GO:0031668 ! cellular response to extracellular stimulus
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0042632
name: cholesterol homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of cholesterol within an organism or cell." [GOC:go_curators]
is_a: GO:0055092 ! sterol homeostasis

[Term]
id: GO:0042633
name: hair cycle
namespace: biological_process
def: "The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:go_curators, http://cancerweb.ncl.ac.uk/, PMID:12230507]
is_a: GO:0042303 ! molting cycle

[Term]
id: GO:0042634
name: regulation of hair cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0042633 ! hair cycle

[Term]
id: GO:0042635
name: positive regulation of hair cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507]
synonym: "activation of hair cycle" NARROW []
synonym: "stimulation of hair cycle" NARROW []
synonym: "up regulation of hair cycle" EXACT []
synonym: "up-regulation of hair cycle" EXACT []
synonym: "upregulation of hair cycle" EXACT []
is_a: GO:0042634 ! regulation of hair cycle
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0042633 ! hair cycle

[Term]
id: GO:0042636
name: negative regulation of hair cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507]
synonym: "down regulation of hair cycle" EXACT []
synonym: "down-regulation of hair cycle" EXACT []
synonym: "downregulation of hair cycle" EXACT []
synonym: "inhibition of hair cycle" NARROW []
is_a: GO:0042634 ! regulation of hair cycle
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0042633 ! hair cycle

[Term]
id: GO:0042637
name: catagen
namespace: biological_process
def: "The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced." [PMID:12535193]
synonym: "hair regression" NARROW []
is_a: GO:0022405 ! hair cycle process
relationship: part_of GO:0048820 ! hair follicle maturation

[Term]
id: GO:0042638
name: exogen
namespace: biological_process
def: "The shedding phase of the hair cycle." [PMID:12230507]
synonym: "hair shedding" NARROW []
is_a: GO:0022405 ! hair cycle process
relationship: part_of GO:0048820 ! hair follicle maturation

[Term]
id: GO:0042639
name: telogen
namespace: biological_process
def: "The resting phase of hair cycle." [PMID:12230507]
synonym: "hair resting phase" NARROW []
is_a: GO:0022405 ! hair cycle process

[Term]
id: GO:0042640
name: anagen
namespace: biological_process
def: "The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair." [PMID:12230507]
synonym: "hair growth" NARROW []
is_a: GO:0022405 ! hair cycle process
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0048820 ! hair follicle maturation

[Term]
id: GO:0042641
name: actomyosin
namespace: cellular_component
def: "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators]
synonym: "actomyosin complex" EXACT []
synonym: "actomyosin structure" EXACT []
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0015629 ! actin cytoskeleton

[Term]
id: GO:0042642
name: actomyosin, myosin complex part
namespace: cellular_component
def: "The myosin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators]
is_a: GO:0016459 ! myosin complex
relationship: part_of GO:0042641 ! actomyosin

[Term]
id: GO:0042643
name: actomyosin, actin part
namespace: cellular_component
def: "The actin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators]
is_a: GO:0005884 ! actin filament
relationship: part_of GO:0042641 ! actomyosin

[Term]
id: GO:0042644
name: chloroplast nucleoid
namespace: cellular_component
def: "The region of a chloroplast to which the DNA is confined." [GOC:jl]
is_a: GO:0042646 ! plastid nucleoid
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0042645
name: mitochondrial nucleoid
namespace: cellular_component
def: "The region of a mitochondrion to which the DNA is confined." [GOC:jl]
is_a: GO:0009295 ! nucleoid
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0042646
name: plastid nucleoid
namespace: cellular_component
def: "The region of a plastid to which the DNA is confined." [GOC:jl]
is_a: GO:0009295 ! nucleoid
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009532 ! plastid stroma

[Term]
id: GO:0042647
name: proplastid nucleoid
namespace: cellular_component
def: "The region of a proplastid to which the DNA is confined." [GOC:jl]
is_a: GO:0042646 ! plastid nucleoid
relationship: part_of GO:0009571 ! proplastid stroma

[Term]
id: GO:0042648
name: chloroplast chromosome
namespace: cellular_component
def: "A circular DNA molecule containing chloroplast encoded genes." [GOC:jl]
is_a: GO:0009508 ! plastid chromosome
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0042644 ! chloroplast nucleoid

[Term]
id: GO:0042649
name: prothylakoid
namespace: cellular_component
def: "Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light." [GOC:jl, PMID:11532175]
is_a: GO:0031976 ! plastid thylakoid
relationship: part_of GO:0009513 ! etioplast

[Term]
id: GO:0042650
name: prothylakoid membrane
namespace: cellular_component
def: "The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes." [GOC:jl, PMID:11532175]
is_a: GO:0055035 ! plastid thylakoid membrane
relationship: part_of GO:0042649 ! prothylakoid

[Term]
id: GO:0042651
name: thylakoid membrane
namespace: cellular_component
def: "The pigmented membrane of any thylakoid." [GOC:jl]
subset: gosubset_prok
is_a: GO:0031090 ! organelle membrane
is_a: GO:0034357 ! photosynthetic membrane
is_a: GO:0044436 ! thylakoid part

[Term]
id: GO:0042652
name: mitochondrial respiratory chain complex I, peripheral segment
namespace: cellular_component
def: "The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jic, GOC:mtg_sensu, ISBN:0716749556]
synonym: "NADH dehydrogenase (ubiquinone) complex, peripheral segment" BROAD []
synonym: "NADH-Q oxidoreductase complex, peripheral segment" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005747 ! mitochondrial respiratory chain complex I

[Term]
id: GO:0042653
name: mitochondrial respiratory chain complex I, membrane segment
namespace: cellular_component
def: "The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jic, GOC:mtg_sensu, ISBN:0716749556]
synonym: "NADH-Q oxidoreductase complex, membrane segment" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005747 ! mitochondrial respiratory chain complex I

[Term]
id: GO:0042654
name: ecdysis-triggering hormone receptor activity
namespace: molecular_function
def: "Combining with ecdysis-triggering hormone to initiate a change in cell activity." [GOC:ma]
synonym: "ecdysis-triggering hormone binding" NARROW []
synonym: "ETH receptor" EXACT []
is_a: GO:0004930 ! G-protein coupled receptor activity
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0042655
name: activation of JNKKK activity
namespace: biological_process
def: "The initiation of the activity of the inactive enzyme JUN kinase kinase kinase activity in response to phosphorylation by a member of the MAP kinase kinase kinase kinase (MAPKKKK) family or another upstream kinase." [GOC:bf]
synonym: "activation of JUN kinase kinase kinase activity" EXACT []
synonym: "positive regulation of JUNKKK activity" BROAD []
is_a: GO:0000185 ! activation of MAPKKK activity
relationship: part_of GO:0007254 ! JNK cascade

[Term]
id: GO:0042656
name: JUN kinase kinase kinase kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs)." [GOC:bf]
synonym: "JUNKKKK activity" EXACT []
is_a: GO:0008349 ! MAP kinase kinase kinase kinase activity

[Term]
id: GO:0042657
name: MHC class II protein binding, via lateral surface
namespace: molecular_function
def: "Interacting selectively and non-covalently with the lateral surface of major histocompatibility complex class II molecules." [GOC:jl]
synonym: "major histocompatibility complex class II protein binding, via lateral surface" EXACT []
is_a: GO:0042289 ! MHC class II protein binding

[Term]
id: GO:0042658
name: MHC class II protein binding, via antigen binding groove
namespace: molecular_function
def: "Interacting selectively and non-covalently with the antigen binding groove of major histocompatibility complex class II molecules." [GOC:jl]
synonym: "major histocompatibility complex class II protein binding, via antigen binding groove" EXACT []
is_a: GO:0042289 ! MHC class II protein binding
relationship: part_of GO:0023026 ! MHC class II protein complex binding

[Term]
id: GO:0042659
name: regulation of cell fate specification
namespace: biological_process
def: "Any process that mediates the adoption of a specific fate by a cell." [GOC:go_curators]
is_a: GO:0010453 ! regulation of cell fate commitment
relationship: regulates GO:0001708 ! cell fate specification

[Term]
id: GO:0042660
name: positive regulation of cell fate specification
namespace: biological_process
def: "Any process that activates or enables a cell to adopt a specific fate." [GOC:go_curators]
synonym: "activation of cell fate specification" NARROW []
synonym: "stimulation of cell fate specification" NARROW []
synonym: "up regulation of cell fate specification" EXACT []
synonym: "up-regulation of cell fate specification" EXACT []
synonym: "upregulation of cell fate specification" EXACT []
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:0045597 ! positive regulation of cell differentiation
relationship: positively_regulates GO:0001708 ! cell fate specification

[Term]
id: GO:0042661
name: regulation of mesodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesoderm cell fate specification." [GOC:go_curators]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0042659 ! regulation of cell fate specification
relationship: regulates GO:0007501 ! mesodermal cell fate specification

[Term]
id: GO:0042662
name: negative regulation of mesodermal cell fate specification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm cell fate specification." [GOC:go_curators]
synonym: "down regulation of mesodermal cell fate specification" EXACT []
synonym: "down-regulation of mesodermal cell fate specification" EXACT []
synonym: "downregulation of mesodermal cell fate specification" EXACT []
synonym: "inhibition of mesodermal cell fate specification" NARROW []
synonym: "suppression of mesodermal cell fate" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
relationship: negatively_regulates GO:0007501 ! mesodermal cell fate specification

[Term]
id: GO:0042663
name: regulation of endodermal cell fate specification
namespace: biological_process
def: "Any process that mediates the specification of a cell into an endoderm cell." [GOC:go_curators]
synonym: "regulation of endoderm cell fate specification" EXACT []
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0042659 ! regulation of cell fate specification
relationship: regulates GO:0001714 ! endodermal cell fate specification

[Term]
id: GO:0042664
name: negative regulation of endodermal cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from specifying into an endoderm cell." [GOC:go_curators]
synonym: "down regulation of endodermal cell fate specification" EXACT []
synonym: "down-regulation of endodermal cell fate specification" EXACT []
synonym: "downregulation of endodermal cell fate specification" EXACT []
synonym: "inhibition of endodermal cell fate specification" NARROW []
synonym: "negative regulation of endoderm cell fate specification" EXACT []
synonym: "suppression of endoderm cell fate" EXACT []
synonym: "suppression of endodermal cell fate" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042663 ! regulation of endodermal cell fate specification
relationship: negatively_regulates GO:0001714 ! endodermal cell fate specification

[Term]
id: GO:0042665
name: regulation of ectodermal cell fate specification
namespace: biological_process
def: "Any process that mediates the specification of a cell into an ectoderm cell." [GOC:go_curators]
synonym: "regulation of ectoderm cell fate specification" EXACT []
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0042659 ! regulation of cell fate specification
relationship: regulates GO:0001715 ! ectodermal cell fate specification

[Term]
id: GO:0042666
name: negative regulation of ectodermal cell fate specification
namespace: biological_process
def: "Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell." [GOC:go_curators]
synonym: "down regulation of ectodermal cell fate specification" EXACT []
synonym: "down-regulation of ectodermal cell fate specification" EXACT []
synonym: "downregulation of ectodermal cell fate specification" EXACT []
synonym: "inhibition of ectodermal cell fate specification" NARROW []
synonym: "negative regulation of ectoderm cell fate specification" EXACT []
synonym: "suppression of ectoderm cell fate" EXACT []
synonym: "suppression of ectodermal cell fate" EXACT []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042665 ! regulation of ectodermal cell fate specification
relationship: negatively_regulates GO:0001715 ! ectodermal cell fate specification

[Term]
id: GO:0042667
name: auditory receptor cell fate specification
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
synonym: "auditory hair cell fate specification" EXACT []
is_a: GO:0048665 ! neuron fate specification
relationship: part_of GO:0009912 ! auditory receptor cell fate commitment

[Term]
id: GO:0042668
name: auditory receptor cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
synonym: "auditory hair cell fate determination" EXACT []
is_a: GO:0048664 ! neuron fate determination
relationship: part_of GO:0009912 ! auditory receptor cell fate commitment

[Term]
id: GO:0042669
name: regulation of auditory receptor cell fate specification
namespace: biological_process
def: "Any process that mediates the specification of a cell into an auditory hair cell." [GOC:go_curators]
synonym: "regulation of auditory hair cell fate specification" EXACT []
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:0045607 ! regulation of auditory receptor cell differentiation
relationship: regulates GO:0042667 ! auditory receptor cell fate specification

[Term]
id: GO:0042670
name: retinal cone cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a retinal cone cell." [GOC:go_curators]
is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation

[Term]
id: GO:0042671
name: retinal cone cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a retinal cone cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]
is_a: GO:0043703 ! photoreceptor cell fate determination
relationship: part_of GO:0046551 ! retinal cone cell fate commitment

[Term]
id: GO:0042672
name: retinal cone cell fate specification
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a retinal cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]
is_a: GO:0043704 ! photoreceptor cell fate specification
relationship: part_of GO:0046551 ! retinal cone cell fate commitment

[Term]
id: GO:0042673
name: regulation of retinal cone cell fate specification
namespace: biological_process
def: "Any process that mediates the specification of a cell into a retinal cone cell." [GOC:go_curators]
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:0060222 ! regulation of retinal cone cell fate commitment
relationship: regulates GO:0042672 ! retinal cone cell fate specification

[Term]
id: GO:0042675
name: compound eye cone cell differentiation
namespace: biological_process
alt_id: GO:0042674
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0042676
name: compound eye cone cell fate commitment
namespace: biological_process
alt_id: GO:0007466
def: "The process whereby the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type." [GOC:mtg_sensu]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0042675 ! compound eye cone cell differentiation

[Term]
id: GO:0042679
name: compound eye cone cell fate specification
namespace: biological_process
alt_id: GO:0042678
def: "Process by which a cell becomes capable of differentiating autonomously into a compound eye cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0042676 ! compound eye cone cell fate commitment

[Term]
id: GO:0042680
name: compound eye cone cell fate determination
namespace: biological_process
alt_id: GO:0042677
def: "Process by which a cell becomes capable of differentiating autonomously into a compound eye cone cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0042676 ! compound eye cone cell fate commitment

[Term]
id: GO:0042682
name: regulation of compound eye cone cell fate specification
namespace: biological_process
alt_id: GO:0042681
def: "Any process that mediates the specification of a cell into a compound eye cone cell." [GOC:mtg_sensu]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0042679 ! compound eye cone cell fate specification

[Term]
id: GO:0042683
name: negative regulation of compound eye cone cell fate specification
namespace: biological_process
alt_id: GO:0010000
def: "Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell." [GOC:mtg_sensu]
synonym: "down regulation of cone cell fate specification" BROAD []
synonym: "down-regulation of cone cell fate specification" BROAD []
synonym: "downregulation of cone cell fate specification" BROAD []
synonym: "inhibition of cone cell fate specification" BROAD []
synonym: "suppression of cone cell fate" BROAD []
is_a: GO:0009996 ! negative regulation of cell fate specification
is_a: GO:0042682 ! regulation of compound eye cone cell fate specification
relationship: negatively_regulates GO:0042679 ! compound eye cone cell fate specification

[Term]
id: GO:0042684
name: cardioblast cell fate commitment
namespace: biological_process
def: "The process by which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0042685
name: cardioblast cell fate specification
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
is_a: GO:0060912 ! cardiac cell fate specification
relationship: part_of GO:0042684 ! cardioblast cell fate commitment

[Term]
id: GO:0042686
name: regulation of cardioblast cell fate specification
namespace: biological_process
def: "Any process that mediates the specification of a cell into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:0051890 ! regulation of cardioblast differentiation
relationship: regulates GO:0042685 ! cardioblast cell fate specification

[Term]
id: GO:0042688
name: crystal cell differentiation
namespace: biological_process
def: "The process by which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]
is_a: GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0042689
name: regulation of crystal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators]
is_a: GO:0045610 ! regulation of hemocyte differentiation
relationship: regulates GO:0042688 ! crystal cell differentiation

[Term]
id: GO:0042690
name: negative regulation of crystal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators]
synonym: "down regulation of crystal cell differentiation" EXACT []
synonym: "down-regulation of crystal cell differentiation" EXACT []
synonym: "downregulation of crystal cell differentiation" EXACT []
synonym: "inhibition of crystal cell differentiation" NARROW []
is_a: GO:0042689 ! regulation of crystal cell differentiation
is_a: GO:0045611 ! negative regulation of hemocyte differentiation
relationship: negatively_regulates GO:0042688 ! crystal cell differentiation

[Term]
id: GO:0042691
name: positive regulation of crystal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators]
synonym: "activation of crystal cell differentiation" NARROW []
synonym: "stimulation of crystal cell differentiation" NARROW []
synonym: "up regulation of crystal cell differentiation" EXACT []
synonym: "up-regulation of crystal cell differentiation" EXACT []
synonym: "upregulation of crystal cell differentiation" EXACT []
is_a: GO:0042689 ! regulation of crystal cell differentiation
is_a: GO:0045612 ! positive regulation of hemocyte differentiation
relationship: positively_regulates GO:0042688 ! crystal cell differentiation

[Term]
id: GO:0042692
name: muscle cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0042693
name: muscle cell fate commitment
namespace: biological_process
def: "The process by which the cellular identity of muscle cells is acquired and determined." [CL:0000187, GOC:go_curators]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0042694
name: muscle cell fate specification
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [CL:0000187, GOC:go_curators]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0042693 ! muscle cell fate commitment

[Term]
id: GO:0042695
name: thelarche
namespace: biological_process
def: "The beginning of development of the breasts in the female." [http://cancerweb.ncl.ac.uk/]
xref: Wikipedia:Thelarche
is_a: GO:0046543 ! development of secondary female sexual characteristics
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0042696
name: menarche
namespace: biological_process
def: "The beginning of the menstrual cycle; the first menstrual cycle in an individual." [http://cancerweb.ncl.ac.uk/]
xref: Wikipedia:Menarche
is_a: GO:0022601 ! menstrual cycle phase
is_a: GO:0046543 ! development of secondary female sexual characteristics

[Term]
id: GO:0042697
name: menopause
namespace: biological_process
def: "Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50." [http://cancerweb.ncl.ac.uk/]
xref: Wikipedia:Menopause
is_a: GO:0022601 ! menstrual cycle phase
is_a: GO:0046543 ! development of secondary female sexual characteristics
relationship: part_of GO:0010259 ! multicellular organismal aging

[Term]
id: GO:0042698
name: ovulation cycle
namespace: biological_process
def: "The type of sexual cycle seen in female mammals, with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "estrous cycle" RELATED []
synonym: "menstrual cycle" RELATED []
is_a: GO:0048511 ! rhythmic process
is_a: GO:0048609 ! reproductive process in a multicellular organism

[Term]
id: GO:0042699
name: follicle-stimulating hormone signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by follicle-stimulating hormone." [GOC:dph]
synonym: "follicle stimulating hormone signaling pathway" EXACT []
synonym: "follicle-stimulating hormone signalling pathway" EXACT []
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0042700
name: luteinizing hormone signaling pathway
namespace: biological_process
def: "The series of molecular signals mediated by luteinizing hormone." [GOC:dph]
synonym: "luteinizing hormone signalling pathway" EXACT []
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0023034 ! intracellular signaling pathway
relationship: part_of GO:0001541 ! ovarian follicle development

[Term]
id: GO:0042701
name: progesterone secretion
namespace: biological_process
def: "The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta." [GOC:jl, ISBN:0395825172]
is_a: GO:0006869 ! lipid transport
is_a: GO:0022602 ! ovulation cycle process
is_a: GO:0060986 ! endocrine hormone secretion
relationship: part_of GO:0001553 ! luteinization

[Term]
id: GO:0042702
name: uterine wall growth
namespace: biological_process
def: "The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels." [GOC:jl]
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0001553 ! luteinization

[Term]
id: GO:0042703
name: menstruation
namespace: biological_process
def: "The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus." [http://cancerweb.ncl.ac.uk/]
xref: Wikipedia:Menstruation
is_a: GO:0022601 ! menstrual cycle phase

[Term]
id: GO:0042704
name: uterine wall breakdown
namespace: biological_process
def: "The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels." [GOC:dph]
is_a: GO:0022602 ! ovulation cycle process
relationship: part_of GO:0042703 ! menstruation

[Term]
id: GO:0042705
name: ocellus photoreceptor cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a photoreceptor cell found in the ocellus." [GOC:go_curators]
is_a: GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0042706
name: eye photoreceptor cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into an eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
is_a: GO:0046552 ! photoreceptor cell fate commitment
relationship: part_of GO:0001754 ! eye photoreceptor cell differentiation

[Term]
id: GO:0042707
name: ocellus photoreceptor cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into photoreceptor cell in the ocellus. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
is_a: GO:0046552 ! photoreceptor cell fate commitment
relationship: part_of GO:0042705 ! ocellus photoreceptor cell differentiation

[Term]
id: GO:0042708
name: elastase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of elastin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0004175

[Term]
id: GO:0042709
name: succinate-CoA ligase complex
namespace: cellular_component
def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP." [EC:6.2.1.4, EC:6.2.1.5, GOC:jl]
subset: gosubset_prok
is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex

[Term]
id: GO:0042710
name: biofilm formation
namespace: biological_process
def: "A process whereby microorganisms irreversibly attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [PMID:11932229]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0042711
name: maternal behavior
namespace: biological_process
def: "Female behaviors associated with the care and rearing of offspring." [GOC:curators]
synonym: "maternal behaviour" EXACT []
is_a: GO:0060746 ! parental behavior

[Term]
id: GO:0042712
name: paternal behavior
namespace: biological_process
def: "Male behaviors associated with the care and rearing offspring." [GOC:go_curators]
synonym: "paternal behaviour" EXACT []
is_a: GO:0060746 ! parental behavior

[Term]
id: GO:0042713
name: sperm ejaculation
namespace: biological_process
def: "The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0007320 ! insemination

[Term]
id: GO:0042714
name: dosage compensation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes." [GOC:jl, PMID:11102361, PMID:12672493]
is_a: GO:0034622 ! cellular macromolecular complex assembly
relationship: part_of GO:0007549 ! dosage compensation

[Term]
id: GO:0042715
name: dosage compensation complex assembly during dosage compensation by hypoactivation of X chromosome
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on both X chromosomes in the monogametic sex, ultimately resulting in a two-fold reduction in transcription from these chromosomes. An example of this process is found in Caenorhabditis elegans." [GOC:jl, PMID:11102361, PMID:12672493]
is_a: GO:0042714 ! dosage compensation complex assembly
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0042464 ! dosage compensation, by hypoactivation of X chromosome

[Term]
id: GO:0042716
name: plasma membrane-derived chromatophore
namespace: cellular_component
def: "A pigment-bearing structure that is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle. This component is found in certain photosynthetic bacteria and cyanobacteria." [GOC:jl, ISBN:0395825172, PMID:11867431]
comment: Note that this structure is distinct from the chromoplast of plants, which is also sometimes called a chromatophore; it also should not be confused with the specialized pigment-producing cells known as chromatophores, found in fish and amphibian skin.
subset: gosubset_prok
synonym: "chromatophore vesicle" RELATED []
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0042717
name: plasma membrane-derived chromatophore membrane
namespace: cellular_component
def: "The lipid bilayer associated with a plasma membrane-derived chromatophore; surrounds chromatophores that form complete vesicles." [GOC:jl, GOC:mah, ISBN:0395825172, PMID:11867431]
subset: gosubset_prok
is_a: GO:0034357 ! photosynthetic membrane
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore

[Term]
id: GO:0042718
name: yolk granule
namespace: cellular_component
def: "Discrete structures that partition the water-insoluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed." [GOC:jl, http://148.216.10.83/cellbio/eggs.htm, PMID:18046696]
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0060417 ! yolk

[Term]
id: GO:0042719
name: mitochondrial intermembrane space protein transporter complex
namespace: cellular_component
def: "Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629]
synonym: "Tim9-Tim10 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005758 ! mitochondrial intermembrane space

[Term]
id: GO:0042720
name: mitochondrial inner membrane peptidase complex
namespace: cellular_component
def: "Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space." [PMID:10821182, PMID:12191769]
synonym: "IMP" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0042721
name: mitochondrial inner membrane protein insertion complex
namespace: cellular_component
def: "A multi-subunit complex embedded in the mitochondrial inner membrane that mediates insertion of carrier proteins into the inner membrane." [PMID:12191765]
synonym: "Tim22 complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044455 ! mitochondrial membrane part
relationship: part_of GO:0005743 ! mitochondrial inner membrane

[Term]
id: GO:0042722
name: alpha-beta T cell activation by superantigen
namespace: biological_process
def: "The change in morphology and behavior of alpha-beta T cells resulting from exposure to a superantigen, a microbial antigen with an extremely potent activating effect on T cells that bear a specific variable region." [GOC:jl, http://cancerweb.ncl.ac.uk/]
synonym: "alpha-beta T lymphocyte activation by superantigen" EXACT []
synonym: "alpha-beta T-cell activation by superantigen" EXACT []
synonym: "alpha-beta T-lymphocyte activation by superantigen" EXACT []
is_a: GO:0002287 ! alpha-beta T cell activation during immune response

[Term]
id: GO:0042723
name: thiamin and derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thiamin (vitamin B1), and compounds derived from it." [GOC:jl]
subset: gosubset_prok
synonym: "thiamin and derivative metabolism" EXACT []
synonym: "thiamine and derivative metabolic process" EXACT []
synonym: "thiamine and derivative metabolism" EXACT []
synonym: "vitamin B1 and derivative metabolic process" EXACT []
synonym: "vitamin B1 and derivative metabolism" EXACT []
xref: Reactome:196819 "Vitamin B1 (thiamin) metabolism"
xref: Reactome:449290 "Vitamin B1 (thiamin) metabolism"
xref: Reactome:470409 "Vitamin B1 (thiamin) metabolism"
xref: Reactome:488086 "Vitamin B1 (thiamin) metabolism"
xref: Reactome:508056 "Vitamin B1 (thiamin) metabolism"
xref: Reactome:517910 "Vitamin B1 (thiamin) metabolism"
xref: Reactome:526738 "Vitamin B1 (thiamin) metabolism"
xref: Reactome:531502 "Vitamin B1 (thiamin) metabolism"
xref: Reactome:536893 "Vitamin B1 (thiamin) metabolism"
xref: Reactome:542641 "Vitamin B1 (thiamin) metabolism"
xref: Reactome:552530 "Vitamin B1 (thiamin) metabolism"
xref: Reactome:558152 "Vitamin B1 (thiamin) metabolism"
xref: Reactome:568782 "Vitamin B1 (thiamin) metabolism"
xref: Reactome:581985 "Vitamin B1 (thiamin) metabolism"
xref: Reactome:592891 "Vitamin B1 (thiamin) metabolism"
xref: Reactome:595592 "Vitamin B1 (thiamin) metabolism"
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0042724
name: thiamin and derivative biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), and related compounds." [GOC:jl]
subset: gosubset_prok
synonym: "thiamin and derivative anabolism" EXACT []
synonym: "thiamin and derivative biosynthesis" EXACT []
synonym: "thiamin and derivative formation" EXACT []
synonym: "thiamin and derivative synthesis" EXACT []
synonym: "thiamine and derivative biosynthesis" EXACT []
synonym: "thiamine and derivative biosynthetic process" EXACT []
synonym: "vitamin B1 and derivative biosynthesis" EXACT []
synonym: "vitamin B1 and derivative biosynthetic process" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0042723 ! thiamin and derivative metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0042725
name: thiamin and derivative catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thiamin (vitamin B1), and compounds derived from it." [GOC:jl]
subset: gosubset_prok
synonym: "thiamin and derivative breakdown" EXACT []
synonym: "thiamin and derivative catabolism" EXACT []
synonym: "thiamin and derivative degradation" EXACT []
synonym: "thiamine and derivative catabolic process" EXACT []
synonym: "thiamine and derivative catabolism" EXACT []
synonym: "vitamin B1 and derivative catabolic process" EXACT []
synonym: "vitamin B1 and derivative catabolism" EXACT []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042723 ! thiamin and derivative metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0042726
name: riboflavin and derivative metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving riboflavin (vitamin B2) or any of its derivatives." [GOC:jl]
subset: gosubset_prok
synonym: "riboflavin and derivative metabolism" EXACT []
synonym: "vitamin B2 and derivative metabolic process" EXACT []
synonym: "vitamin B2 and derivative metabolism" EXACT []
is_a: GO:0006767 ! water-soluble vitamin metabolic process

[Term]
id: GO:0042727
name: riboflavin and derivative biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2) or any of its derivatives." [GOC:jl]
subset: gosubset_prok
synonym: "riboflavin and derivative anabolism" EXACT []
synonym: "riboflavin and derivative biosynthesis" EXACT []
synonym: "riboflavin and derivative formation" EXACT []
synonym: "riboflavin and derivative synthesis" EXACT []
synonym: "vitamin B2 and derivative biosynthesis" EXACT []
synonym: "vitamin B2 and derivative biosynthetic process" EXACT []
is_a: GO:0042726 ! riboflavin and derivative metabolic process

[Term]
id: GO:0042728
name: riboflavin and derivative catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2) or any of its derivatives." [GOC:jl]
subset: gosubset_prok
synonym: "riboflavin and derivative breakdown" EXACT []
synonym: "riboflavin and derivative catabolism" EXACT []
synonym: "riboflavin and derivative degradation" EXACT []
synonym: "vitamin B2 and derivative catabolic process" EXACT []
synonym: "vitamin B2 and derivative catabolism" EXACT []
is_a: GO:0042726 ! riboflavin and derivative metabolic process

[Term]
id: GO:0042729
name: DASH complex
namespace: cellular_component
alt_id: GO:0043925
alt_id: GO:0043926
def: "A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability." [GOC:jl, PMID:11782438, PMID:11799062]
comment: Note that this complex is conserved in fungi but has not been observed in metazoans.
synonym: "condensed nuclear chromosome kinetochore-associated DASH complex" EXACT []
synonym: "Dam1 complex" EXACT []
synonym: "DDD complex" EXACT []
synonym: "Duo1p-Dam1p-Dad1p complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore

[Term]
id: GO:0042730
name: fibrinolysis
namespace: biological_process
def: "An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots." [GOC:jl, http://cancerweb.ncl.ac.uk/]
xref: Reactome:448790 "Dissolution of Fibrin Clot"
xref: Reactome:469905 "Dissolution of Fibrin Clot"
xref: Reactome:487612 "Dissolution of Fibrin Clot"
xref: Reactome:507567 "Dissolution of Fibrin Clot"
xref: Reactome:558061 "Dissolution of Fibrin Clot"
xref: Reactome:75205 "Dissolution of Fibrin Clot"
xref: Wikipedia:Fibrinolysis
is_a: GO:0030195 ! negative regulation of blood coagulation

[Term]
id: GO:0042731
name: PH domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton." [GOC:jl, Pfam:PF00169]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0042732
name: D-xylose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-xylose metabolism" EXACT []
is_a: GO:0019321 ! pentose metabolic process

[Term]
id: GO:0042733
name: embryonic digit morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. Morphogenesis pertains to the creation of form. A digit is one of the terminal divisions of an appendage. For example a finger or toe." [GOC:bf, GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0030326 ! embryonic limb morphogenesis

[Term]
id: GO:0042734
name: presynaptic membrane
namespace: cellular_component
def: "A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0016020 ! membrane
is_a: GO:0044456 ! synapse part

[Term]
id: GO:0042735
name: protein body
namespace: cellular_component
def: "A membrane-bounded plant organelle found in the developing endosperm, contains storage proteins." [GOC:jl, PMID:7704047]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0042736
name: NADH kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + NADH = ADP + NADPH." [PMID:12727869]
synonym: "ATP:NADH 2'-phosphotransferase activity" EXACT [EC:2.7.1.86]
synonym: "DPNH kinase activity" EXACT [EC:2.7.1.86]
synonym: "reduced diphosphopyridine nucleotide kinase activity" EXACT [EC:2.7.1.86]
synonym: "reduced nicotinamide adenine dinucleotide kinase (phosphorylating)" EXACT [EC:2.7.1.86]
xref: EC:2.7.1.86
xref: MetaCyc:NADH-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0042737
name: drug catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease." [GOC:go_curators]
subset: gosubset_prok
synonym: "drug breakdown" EXACT []
synonym: "drug catabolism" EXACT []
synonym: "drug degradation" EXACT []
is_a: GO:0017144 ! drug metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0042738
name: exogenous drug catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism." [GOC:jl]
subset: gosubset_prok
synonym: "exogenous drug breakdown" EXACT []
synonym: "exogenous drug catabolism" EXACT []
synonym: "exogenous drug degradation" EXACT []
is_a: GO:0042737 ! drug catabolic process
relationship: part_of GO:0042493 ! response to drug

[Term]
id: GO:0042739
name: endogenous drug catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a drug that has originated internally within the cell or organism." [GOC:jl]
subset: gosubset_prok
synonym: "endogenous drug breakdown" EXACT []
synonym: "endogenous drug catabolism" EXACT []
synonym: "endogenous drug degradation" EXACT []
is_a: GO:0042737 ! drug catabolic process

[Term]
id: GO:0042740
name: exogenous antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated externally to the cell or organism." [GOC:jl]
subset: gosubset_prok
synonym: "exogenous antibiotic breakdown" EXACT []
synonym: "exogenous antibiotic catabolism" EXACT []
synonym: "exogenous antibiotic degradation" EXACT []
is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0042738 ! exogenous drug catabolic process
relationship: part_of GO:0046677 ! response to antibiotic

[Term]
id: GO:0042741
name: endogenous antibiotic catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated internally within the cell or organism." [GOC:jl]
subset: gosubset_prok
synonym: "endogenous antibiotic breakdown" EXACT []
synonym: "endogenous antibiotic catabolism" EXACT []
synonym: "endogenous antibiotic degradation" EXACT []
is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0042739 ! endogenous drug catabolic process

[Term]
id: GO:0042742
name: defense response to bacterium
namespace: biological_process
alt_id: GO:0042830
def: "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]
subset: gosubset_prok
synonym: "antibacterial peptide activity" RELATED []
synonym: "defence response to bacteria" EXACT []
synonym: "defence response to bacterium" EXACT []
synonym: "defense response to bacteria" EXACT []
is_a: GO:0006952 ! defense response
is_a: GO:0009617 ! response to bacterium

[Term]
id: GO:0042743
name: hydrogen peroxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:jl, http://biotech.icmb.utexas.edu/]
subset: gosubset_prok
synonym: "H2O2 metabolic process" EXACT [GOC:mah]
synonym: "hydrogen peroxide metabolism" EXACT []
is_a: GO:0006800 ! oxygen and reactive oxygen species metabolic process

[Term]
id: GO:0042744
name: hydrogen peroxide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]
subset: gosubset_prok
synonym: "detoxification of H2O2" RELATED [GOC:vw]
synonym: "detoxification of hydrogen peroxide" RELATED [GOC:vw]
synonym: "H2O2 catabolic process" EXACT [GOC:mah]
synonym: "H2O2 scavenging" RELATED [GOC:vw]
synonym: "hydrogen peroxide breakdown" EXACT []
synonym: "hydrogen peroxide catabolism" EXACT []
synonym: "hydrogen peroxide degradation" EXACT []
synonym: "hydrogen peroxide removal" RELATED []
synonym: "hydrogen peroxide scavenging" RELATED [GOC:vw]
xref: Reactome:448515 "Breakdown of hydrogen peroxide to water and molecular oxygen"
xref: Reactome:469645 "Breakdown of hydrogen peroxide to water and molecular oxygen"
xref: Reactome:487357 "Breakdown of hydrogen peroxide to water and molecular oxygen"
xref: Reactome:507308 "Breakdown of hydrogen peroxide to water and molecular oxygen"
xref: Reactome:517323 "Breakdown of hydrogen peroxide to water and molecular oxygen"
xref: Reactome:526205 "Breakdown of hydrogen peroxide to water and molecular oxygen"
xref: Reactome:531091 "Breakdown of hydrogen peroxide to water and molecular oxygen"
xref: Reactome:536465 "Breakdown of hydrogen peroxide to water and molecular oxygen"
xref: Reactome:542168 "Breakdown of hydrogen peroxide to water and molecular oxygen"
xref: Reactome:547528 "Breakdown of hydrogen peroxide to water and molecular oxygen"
xref: Reactome:552119 "Breakdown of hydrogen peroxide to water and molecular oxygen"
xref: Reactome:568326 "Breakdown of hydrogen peroxide to water and molecular oxygen"
xref: Reactome:581528 "Breakdown of hydrogen peroxide to water and molecular oxygen"
xref: Reactome:592415 "Breakdown of hydrogen peroxide to water and molecular oxygen"
xref: Reactome:599614 "Breakdown of hydrogen peroxide to water and molecular oxygen"
xref: Reactome:77102 "Breakdown of hydrogen peroxide to water and molecular oxygen"
is_a: GO:0042743 ! hydrogen peroxide metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0070301 ! cellular response to hydrogen peroxide

[Term]
id: GO:0042745
name: circadian sleep/wake cycle
namespace: biological_process
def: "The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:jl, http://www.sleepquest.com]
is_a: GO:0030431 ! sleep
is_a: GO:0048512 ! circadian behavior

[Term]
id: GO:0042746
name: circadian sleep/wake cycle, wakefulness
namespace: biological_process
def: "The part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:jl, PMID:12575468]
is_a: GO:0022410 ! circadian sleep/wake cycle process

[Term]
id: GO:0042747
name: circadian sleep/wake cycle, REM sleep
namespace: biological_process
def: "A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity." [GOC:jl, ISBN:0395825172]
is_a: GO:0022410 ! circadian sleep/wake cycle process
relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep

[Term]
id: GO:0042748
name: circadian sleep/wake cycle, non-REM sleep
namespace: biological_process
def: "All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions." [GOC:jl, http://www.sleepquest.com]
is_a: GO:0022410 ! circadian sleep/wake cycle process
relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep

[Term]
id: GO:0042749
name: regulation of circadian sleep/wake cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle." [GOC:jl]
is_a: GO:0022410 ! circadian sleep/wake cycle process
is_a: GO:0042752 ! regulation of circadian rhythm
is_a: GO:0050795 ! regulation of behavior
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0042745 ! circadian sleep/wake cycle

[Term]
id: GO:0042750
name: hibernation
namespace: biological_process
def: "Any process by which an organism enters and maintains a period of dormancy in which to pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs." [GOC:jl, http://cancerweb.ncl.ac.uk/]
xref: Wikipedia:Hibernation
is_a: GO:0022611 ! dormancy process
is_a: GO:0030431 ! sleep

[Term]
id: GO:0042751
name: estivation
namespace: biological_process
def: "Any process by which an organism enters and maintains a period of dormancy, similar to hibernation, but that occurs during the summer. It insulates against heat to prevent the harmful effects of the season." [GOC:jl, http://www.wikipedia.org/Estivation]
xref: Wikipedia:Estivation
is_a: GO:0022611 ! dormancy process
is_a: GO:0030431 ! sleep

[Term]
id: GO:0042752
name: regulation of circadian rhythm
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0007623 ! circadian rhythm

[Term]
id: GO:0042753
name: positive regulation of circadian rhythm
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators]
synonym: "activation of circadian rhythm" NARROW []
synonym: "stimulation of circadian rhythm" NARROW []
synonym: "up regulation of circadian rhythm" EXACT []
synonym: "up-regulation of circadian rhythm" EXACT []
synonym: "upregulation of circadian rhythm" EXACT []
is_a: GO:0042752 ! regulation of circadian rhythm
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0007623 ! circadian rhythm

[Term]
id: GO:0042754
name: negative regulation of circadian rhythm
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators]
synonym: "down regulation of circadian rhythm" EXACT []
synonym: "down-regulation of circadian rhythm" EXACT []
synonym: "downregulation of circadian rhythm" EXACT []
synonym: "inhibition of circadian rhythm" NARROW []
is_a: GO:0042752 ! regulation of circadian rhythm
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0007623 ! circadian rhythm

[Term]
id: GO:0042755
name: eating behavior
namespace: biological_process
def: "The specific actions or reactions of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue." [GOC:jl, ISBN:01928006X]
synonym: "eating behaviour" EXACT []
is_a: GO:0007631 ! feeding behavior

[Term]
id: GO:0042756
name: drinking behavior
namespace: biological_process
def: "The specific actions or reactions of an organism relating to the intake of liquids, especially water." [GOC:jl, http://cancerweb.ncl.ac.uk/]
synonym: "drinking behaviour" EXACT []
is_a: GO:0007631 ! feeding behavior

[Term]
id: GO:0042757
name: giant axon
namespace: cellular_component
def: "Extremely large, unmyelinated axon found in invertebrates. Has high conduction speeds and is usually involved in panic or escape responses." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0030424 ! axon

[Term]
id: GO:0042758
name: long-chain fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18." [GOC:go_curators]
subset: gosubset_prok
synonym: "long-chain fatty acid breakdown" EXACT []
synonym: "long-chain fatty acid catabolism" EXACT []
synonym: "long-chain fatty acid degradation" EXACT []
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0009062 ! fatty acid catabolic process

[Term]
id: GO:0042759
name: long-chain fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18." [GOC:go_curators]
subset: gosubset_prok
synonym: "long-chain fatty acid anabolism" EXACT []
synonym: "long-chain fatty acid biosynthesis" EXACT []
synonym: "long-chain fatty acid formation" EXACT []
synonym: "long-chain fatty acid synthesis" EXACT []
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0042760
name: very-long-chain fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of C18 or greater." [GOC:go_curators]
subset: gosubset_prok
synonym: "very-long-chain fatty acid breakdown" EXACT []
synonym: "very-long-chain fatty acid catabolism" EXACT []
synonym: "very-long-chain fatty acid degradation" EXACT []
is_a: GO:0000038 ! very-long-chain fatty acid metabolic process
is_a: GO:0009062 ! fatty acid catabolic process

[Term]
id: GO:0042761
name: very-long-chain fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of C18 or greater." [GOC:go_curators]
subset: gosubset_prok
synonym: "very-long-chain fatty acid anabolism" EXACT []
synonym: "very-long-chain fatty acid biosynthesis" EXACT []
synonym: "very-long-chain fatty acid formation" EXACT []
synonym: "very-long-chain fatty acid synthesis" EXACT []
xref: MetaCyc:PWY-5080
is_a: GO:0000038 ! very-long-chain fatty acid metabolic process
is_a: GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0042762
name: regulation of sulfur metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of sulfur metabolism" EXACT []
synonym: "regulation of sulphur metabolic process" EXACT []
synonym: "regulation of sulphur metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
relationship: regulates GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0042763
name: intracellular immature spore
namespace: cellular_component
def: "A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants." [GOC:jl, ISBN:0395825172]
subset: gosubset_prok
synonym: "forespore" RELATED []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0042764
name: ascospore-type prospore
namespace: cellular_component
def: "An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascopore-forming fungi." [GOC:go_curators]
is_a: GO:0042763 ! intracellular immature spore

[Term]
id: GO:0042765
name: GPI-anchor transamidase complex
namespace: cellular_component
def: "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]
comment: Note that this term should not be confused with 'glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ; GO:0000506', which represents a distinct complex with a different catalytic activity.
synonym: "GPIT complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0030176 ! integral to endoplasmic reticulum membrane

[Term]
id: GO:0042766
name: nucleosome mobilization
namespace: biological_process
def: "The movement of nucleosomes along a DNA fragment." [PMID:12006495]
is_a: GO:0006338 ! chromatin remodeling
is_a: GO:0034728 ! nucleosome organization

[Term]
id: GO:0042767
name: ecdysteroid 22-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 22." [PMID:12177427]
comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22-dideoxyecdysone (ketotriol) to 2-deoxyecdysone.
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0042768
name: ecdysteroid 2-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 2." [PMID:12177427]
comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2-deoxyecdysone to ecdysone. It can also catalyze the conversion of 2,22-dideoxyecdysone (ketotriol) to 22-deoxyecdysone.
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0042769
name: DNA damage response, detection of DNA damage
namespace: biological_process
def: "The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal." [GOC:go_curators]
synonym: "detection of DNA damage during DNA damage response" EXACT []
synonym: "DNA damage response, perception of DNA damage" RELATED []
is_a: GO:0006974 ! response to DNA damage stimulus
is_a: GO:0051606 ! detection of stimulus

[Term]
id: GO:0042770
name: DNA damage response, signal transduction
namespace: biological_process
def: "A cascade of processes induced by the detection of DNA damage within a cell." [GOC:go_curators]
is_a: GO:0006974 ! response to DNA damage stimulus
is_a: GO:0007242 ! intracellular signaling cascade

[Term]
id: GO:0042771
name: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
namespace: biological_process
def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the initiation of apoptosis (programmed cell death)." [GOC:go_curators]
is_a: GO:0008630 ! DNA damage response, signal transduction resulting in induction of apoptosis
is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator

[Term]
id: GO:0042772
name: DNA damage response, signal transduction resulting in transcription
namespace: biological_process
def: "A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription." [GOC:go_curators]
is_a: GO:0042770 ! DNA damage response, signal transduction

[Term]
id: GO:0042773
name: ATP synthesis coupled electron transport
namespace: biological_process
def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363]
subset: gosubset_prok
is_a: GO:0022904 ! respiratory electron transport chain
relationship: part_of GO:0006119 ! oxidative phosphorylation

[Term]
id: GO:0042774
name: plasma membrane ATP synthesis coupled electron transport
namespace: biological_process
def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP in the plasma membrane." [GOC:mtg_sensu, ISBN:0716731363]
subset: gosubset_prok
is_a: GO:0042773 ! ATP synthesis coupled electron transport

[Term]
id: GO:0042775
name: mitochondrial ATP synthesis coupled electron transport
namespace: biological_process
def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363]
synonym: "mitochondrial electron transport" BROAD []
synonym: "organelle ATP synthesis coupled electron transport" BROAD []
xref: Reactome:163200 "Electron Transport Chain"
xref: Reactome:449070 "Electron Transport Chain"
xref: Reactome:470183 "Electron Transport Chain"
xref: Reactome:487868 "Electron Transport Chain"
xref: Reactome:507840 "Electron Transport Chain"
xref: Reactome:517747 "Electron Transport Chain"
xref: Reactome:526584 "Electron Transport Chain"
xref: Reactome:531486 "Electron Transport Chain"
xref: Reactome:536870 "Electron Transport Chain"
xref: Reactome:542625 "Electron Transport Chain"
xref: Reactome:547941 "Electron Transport Chain"
xref: Reactome:552516 "Electron Transport Chain"
xref: Reactome:558140 "Electron Transport Chain"
xref: Reactome:568767 "Electron Transport Chain"
xref: Reactome:581970 "Electron Transport Chain"
xref: Reactome:592877 "Electron Transport Chain"
xref: Reactome:597445 "Electron Transport Chain"
xref: Reactome:599780 "Electron Transport Chain"
xref: Reactome:602612 "Electron Transport Chain"
is_a: GO:0042773 ! ATP synthesis coupled electron transport

[Term]
id: GO:0042776
name: mitochondrial ATP synthesis coupled proton transport
namespace: biological_process
def: "The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [GOC:mtg_sensu, ISBN:0716731363]
synonym: "mitochondrial proton transport" BROAD []
xref: Reactome:163210 "Formation of ATP by chemiosmotic coupling"
xref: Reactome:164834 "Enzyme-bound ATP is released"
xref: Reactome:437617 "Enzyme-bound ATP is released"
xref: Reactome:448769 "Formation of ATP by chemiosmotic coupling"
xref: Reactome:459708 "Enzyme-bound ATP is released"
xref: Reactome:469884 "Formation of ATP by chemiosmotic coupling"
xref: Reactome:478850 "Enzyme-bound ATP is released"
xref: Reactome:487586 "Formation of ATP by chemiosmotic coupling"
xref: Reactome:498641 "Enzyme-bound ATP is released"
xref: Reactome:507544 "Formation of ATP by chemiosmotic coupling"
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0015986 ! ATP synthesis coupled proton transport

[Term]
id: GO:0042777
name: plasma membrane ATP synthesis coupled proton transport
namespace: biological_process
def: "The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [GOC:mtg_sensu, ISBN:0716731363]
subset: gosubset_prok
synonym: "ATP synthesis coupled proton transport" BROAD []
is_a: GO:0015986 ! ATP synthesis coupled proton transport

[Term]
id: GO:0042778
name: tRNA end turnover
namespace: biological_process
def: "Process by which the 3'-terminal CCA of a tRNA is removed and restored. This often happens to uncharged tRNA." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006399 ! tRNA metabolic process

[Term]
id: GO:0042779
name: tRNA 3'-trailer cleavage
namespace: biological_process
def: "Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both." [GOC:go_curators]
subset: gosubset_prok
synonym: "removal of tRNA 3'-trailer sequence" EXACT []
synonym: "tRNA 3'-end cleavage" EXACT []
is_a: GO:0042780 ! tRNA 3'-end processing

[Term]
id: GO:0042780
name: tRNA 3'-end processing
namespace: biological_process
def: "The process by which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "tRNA 3' processing" EXACT []
is_a: GO:0008033 ! tRNA processing
is_a: GO:0043628 ! ncRNA 3'-end processing

[Term]
id: GO:0042781
name: 3'-tRNA processing endoribonuclease activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule." [EC:3.1.26.11]
subset: gosubset_prok
synonym: "3 tRNase activity" EXACT [EC:3.1.26.11]
synonym: "3' tRNA processing endoribonuclease activity" EXACT []
synonym: "3' tRNase activity" BROAD []
synonym: "ribonuclease Z activity" BROAD []
synonym: "RNase Z activity" BROAD []
synonym: "tRNA 3 endonuclease activity" EXACT [EC:3.1.26.11]
synonym: "tRNA 3' endonuclease activity" EXACT []
synonym: "tRNase Z" RELATED [EC:3.1.26.11]
synonym: "tRNAse Z" RELATED [EC:3.1.26.11]
xref: MetaCyc:3.1.26.11-RXN
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0042782
name: passive evasion of host immune response
namespace: biological_process
def: "Any mechanism of immune avoidance that does not directly interfere with the host immune system; for example, some viruses enter a state of latency where their protein production is drastically downregulated, meaning that they are not detected by the host immune system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615]
subset: gosubset_prok
synonym: "passive immune evasion" BROAD []
is_a: GO:0020012 ! evasion or tolerance of host immune response
is_a: GO:0051809 ! passive evasion of immune response of other organism during symbiotic interaction

[Term]
id: GO:0042783
name: active evasion of host immune response
namespace: biological_process
def: "Any mechanism of immune avoidance that directly affects the host immune system, e.g. blocking any stage in host MHC class I and II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615]
subset: gosubset_prok
synonym: "active immune evasion" BROAD []
is_a: GO:0020012 ! evasion or tolerance of host immune response
is_a: GO:0051810 ! active evasion of immune response of other organism during symbiotic interaction

[Term]
id: GO:0042784
name: active evasion of host immune response via regulation of host complement system
namespace: biological_process
def: "Any mechanism of active immune avoidance which works by regulating the host complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, host macrophages, which are eventually destroyed. The host is defined as the larger of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html]
synonym: "active immune evasion via modulation of host complement system" EXACT []
synonym: "active immune evasion via regulation of host complement system" EXACT []
is_a: GO:0042783 ! active evasion of host immune response
is_a: GO:0051811 ! active evasion of immune response of other organism via regulation of complement system of other organism during symbiotic interaction

[Term]
id: GO:0042785
name: active evasion of host immune response via regulation of host cytokine network
namespace: biological_process
def: "Any mechanism of active immune avoidance which works by regulating host cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester host cytokines and inhibit action. The host is defined as the larger of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation]
synonym: "active immune evasion via modulation of host cytokine network" EXACT []
synonym: "active immune evasion via regulation of host cytokine network" EXACT []
is_a: GO:0042783 ! active evasion of host immune response
is_a: GO:0051812 ! active evasion of immune response of other organism via regulation of cytokine network of other organism during symbiotic interaction

[Term]
id: GO:0042786
name: active evasion of host immune response via regulation of host antigen processing and presentation
namespace: biological_process
def: "Any mechanism of active immune avoidance which works by regulating the host's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615]
synonym: "active evasion of host immune response via regulation of host antigen processing and presentation pathway" EXACT []
synonym: "active immune evasion via modulation of antigen processing and presentation" EXACT []
synonym: "active immune evasion via modulation of antigen processing/presentation" EXACT []
synonym: "active immune evasion via regulation of antigen processing and presentation" EXACT []
is_a: GO:0042783 ! active evasion of host immune response

[Term]
id: GO:0042787
name: protein ubiquitination during ubiquitin-dependent protein catabolic process
namespace: biological_process
alt_id: GO:0043432
def: "The process by which a ubiquitin moiety, or multiple moieties, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators]
synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW []
synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" NARROW []
synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW []
synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" NARROW []
synonym: "protein degradation tagging activity" RELATED []
synonym: "protein ubiquitination during ubiquitin-dependent protein breakdown" EXACT []
synonym: "protein ubiquitination during ubiquitin-dependent protein catabolism" EXACT []
synonym: "protein ubiquitination during ubiquitin-dependent protein degradation" EXACT []
synonym: "protein ubiquitinylation during ubiquitin-dependent protein catabolic process" EXACT []
synonym: "protein ubiquitinylation during ubiquitin-dependent protein catabolism" EXACT []
synonym: "protein ubiquitylation during ubiquitin-dependent protein catabolic process" EXACT []
synonym: "protein ubiquitylation during ubiquitin-dependent protein catabolism" EXACT []
xref: Reactome:174057 "Multiubiquitination of APC/C-associated Cdh1"
xref: Reactome:174104 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex"
xref: Reactome:174144 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex"
xref: Reactome:174195 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex"
xref: Reactome:174227 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex"
xref: Reactome:442563 "Multiubiquitination of APC/C-associated Cdh1"
xref: Reactome:448017 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex"
xref: Reactome:448019 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex"
xref: Reactome:448021 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex"
xref: Reactome:448029 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex"
xref: Reactome:464293 "Multiubiquitination of APC/C-associated Cdh1"
xref: Reactome:469222 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex"
xref: Reactome:469224 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex"
xref: Reactome:469226 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex"
xref: Reactome:469234 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex"
xref: Reactome:482664 "Multiubiquitination of APC/C-associated Cdh1"
xref: Reactome:487015 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex"
xref: Reactome:487017 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex"
xref: Reactome:487019 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex"
xref: Reactome:487025 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex"
xref: Reactome:502935 "Multiubiquitination of APC/C-associated Cdh1"
xref: Reactome:506865 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex"
xref: Reactome:506867 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex"
xref: Reactome:506869 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex"
xref: Reactome:506877 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex"
xref: Reactome:515085 "Multiubiquitination of APC/C-associated Cdh1"
xref: Reactome:517085 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex"
xref: Reactome:517087 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex"
xref: Reactome:517089 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex"
xref: Reactome:517095 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex"
xref: Reactome:536305 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex"
xref: Reactome:546499 "Multiubiquitination of APC/C-associated Cdh1"
xref: Reactome:547398 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex"
xref: Reactome:547400 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex"
xref: Reactome:547402 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex"
xref: Reactome:547406 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex"
xref: Reactome:551263 "Multiubiquitination of APC/C-associated Cdh1"
xref: Reactome:551974 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex"
xref: Reactome:551976 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex"
xref: Reactome:551978 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex"
xref: Reactome:551980 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex"
xref: Reactome:557529 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex"
xref: Reactome:557531 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex"
xref: Reactome:566410 "Multiubiquitination of APC/C-associated Cdh1"
xref: Reactome:568036 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex"
xref: Reactome:568038 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex"
xref: Reactome:568040 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex"
xref: Reactome:568041 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex"
xref: Reactome:579284 "Multiubiquitination of APC/C-associated Cdh1"
xref: Reactome:581193 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex"
xref: Reactome:581195 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex"
xref: Reactome:581197 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex"
xref: Reactome:581198 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex"
xref: Reactome:590907 "Multiubiquitination of APC/C-associated Cdh1"
xref: Reactome:592254 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex"
xref: Reactome:592256 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex"
xref: Reactome:592258 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex"
xref: Reactome:592260 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex"
is_a: GO:0016567 ! protein ubiquitination
relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process

[Term]
id: GO:0042788
name: polysomal ribosome
namespace: cellular_component
def: "A ribosome bound to mRNA that forms part of a polysome." [GOC:jl]
synonym: "active ribosome" BROAD []
is_a: GO:0005840 ! ribosome
relationship: part_of GO:0005844 ! polysome

[Term]
id: GO:0042789
name: mRNA transcription from RNA polymerase II promoter
namespace: biological_process
def: "The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II-specific promoter." [GOC:jl, ISBN:0321000382]
synonym: "mRNA transcription from Pol II promoter" EXACT []
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0009299 ! mRNA transcription

[Term]
id: GO:0042790
name: transcription of nuclear rRNA large RNA polymerase I transcript
namespace: biological_process
def: "The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template." [GOC:jl, ISBN:0321000382]
synonym: "transcription of nuclear rRNA large Pol I transcript" EXACT []
is_a: GO:0006360 ! transcription from RNA polymerase I promoter
is_a: GO:0009303 ! rRNA transcription

[Term]
id: GO:0042791
name: 5S class rRNA transcription
namespace: biological_process
def: "The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template." [GOC:jl, ISBN:0321000382]
subset: gosubset_prok
synonym: "5S rRNA transcription" EXACT []
is_a: GO:0006383 ! transcription from RNA polymerase III promoter
is_a: GO:0009303 ! rRNA transcription

[Term]
id: GO:0042792
name: rRNA transcription from mitochondrial promoter
namespace: biological_process
def: "The synthesis of ribosomal RNA (rRNA) from a mitochondrial DNA template." [GOC:jl, ISBN:0321000382]
is_a: GO:0006390 ! transcription from mitochondrial promoter
is_a: GO:0009303 ! rRNA transcription

[Term]
id: GO:0042793
name: transcription from plastid promoter
namespace: biological_process
def: "The synthesis of RNA from a plastid DNA template, usually by a specific plastid RNA polymerase." [GOC:jl, ISBN:0321000382]
synonym: "plastid transcription" EXACT []
is_a: GO:0006351 ! transcription, DNA-dependent
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0042794
name: rRNA transcription from plastid promoter
namespace: biological_process
def: "The synthesis of ribosomal RNA (rRNA) from a plastid DNA template, usually by a specific plastid RNA polymerase." [GOC:jl, ISBN:0321000382]
is_a: GO:0009303 ! rRNA transcription
is_a: GO:0042793 ! transcription from plastid promoter

[Term]
id: GO:0042795
name: snRNA transcription from RNA polymerase II promoter
namespace: biological_process
def: "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382]
synonym: "snRNA transcription from Pol II promoter" EXACT []
is_a: GO:0006366 ! transcription from RNA polymerase II promoter
is_a: GO:0009301 ! snRNA transcription

[Term]
id: GO:0042796
name: snRNA transcription from RNA polymerase III promoter
namespace: biological_process
def: "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]
synonym: "snRNA transcription from Pol III promoter" EXACT []
is_a: GO:0006383 ! transcription from RNA polymerase III promoter
is_a: GO:0009301 ! snRNA transcription

[Term]
id: GO:0042797
name: tRNA transcription from RNA polymerase III promoter
namespace: biological_process
def: "The synthesis of transfer RNA (tRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]
synonym: "tRNA transcription from Pol III promoter" EXACT []
is_a: GO:0006383 ! transcription from RNA polymerase III promoter
is_a: GO:0009304 ! tRNA transcription

[Term]
id: GO:0042798
name: protein neddylation during NEDD8 class-dependent protein catabolic process
namespace: biological_process
def: "OBSOLETE. Covalent attachment of the ubiquitin-like protein NEDD8 (or equivalent protein) to another protein, as a part of NEDD8-dependant protein catabolism." [GOC:jl]
comment: This term was made obsolete because NEDD8-class tags do not target proteins for proteolytic destruction.
synonym: "protein neddylation during NEDD8 class-dependent protein breakdown" EXACT []
synonym: "protein neddylation during NEDD8 class-dependent protein catabolism" EXACT []
synonym: "protein neddylation during NEDD8 class-dependent protein degradation" EXACT []
synonym: "protein neddylation during RUB1-dependent protein catabolic process" EXACT []
synonym: "protein neddylation during RUB1-dependent protein catabolism" EXACT []
is_obsolete: true
consider: GO:0045116

[Term]
id: GO:0042799
name: histone methyltransferase activity (H4-K20 specific)
namespace: molecular_function
def: "Catalysis of the addition of a methyl group onto lysine at position 20 of the histone H4 protein." [PMID:12086618]
comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H4 protein, but that this term still applies.
synonym: "histone H4 lysine 20-specific methyltransferase activity" EXACT []
synonym: "histone lysine N-methyltransferase activity (H4-K20 specific)" EXACT []
synonym: "histone methylase activity (H4-K20 specific)" EXACT [GOC:mah]
is_a: GO:0018024 ! histone-lysine N-methyltransferase activity

[Term]
id: GO:0042800
name: histone methyltransferase activity (H3-K4 specific)
namespace: molecular_function
def: "Catalysis of the addition of a methyl group onto lysine at position 4 of the histone H3 protein." [PMID:12589755]
comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H3 protein, but that this term still applies.
synonym: "histone H3 lysine 4-specific methyltransferase activity" EXACT []
synonym: "histone lysine N-methyltransferase activity (H3-K4 specific)" EXACT []
synonym: "histone methylase activity (H3-K4 specific)" EXACT [GOC:mah]
is_a: GO:0018024 ! histone-lysine N-methyltransferase activity

[Term]
id: GO:0042801
name: polo kinase kinase activity
namespace: molecular_function
def: "Catalysis of the addition of a phosphate group onto a serine or threonine residue in any member of the polo kinase class of proteins." [GOC:ma]
is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity

[Term]
id: GO:0042802
name: identical protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl]
subset: gosubset_prok
synonym: "protein homopolymerization" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0042803
name: protein homodimerization activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]
subset: gosubset_prok
synonym: "dimerization activity" BROAD []
is_a: GO:0042802 ! identical protein binding
is_a: GO:0046983 ! protein dimerization activity

[Term]
id: GO:0042804
name: protein homooligomerization activity
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with identical proteins to form a homooligomer." [GOC:jl]
comment: This term was made obsolete because it represents a biological process.
synonym: "oligomerization activity" BROAD []
is_obsolete: true
replaced_by: GO:0051260

[Term]
id: GO:0042805
name: actinin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0042806
name: fucose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with fucose, the pentose 6-deoxygalactose." [ChEBI:33984, ISBN:0582227089]
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0042807
name: central vacuole
namespace: cellular_component
def: "A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination." [http://www.wikipedia.org/Vacuole]
is_a: GO:0000325 ! plant-type vacuole

[Term]
id: GO:0042808
name: neuronal Cdc2-like kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with neuronal Cdc2-like kinase, an enzyme involved in the regulation of neuronal differentiation and neuro-cytoskeleton dynamics." [GOC:jl, PMID:10721722]
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0042809
name: vitamin D receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes." [GOC:jl, PMID:12637589]
synonym: "calciferol receptor binding" NARROW []
synonym: "VDR binding" EXACT []
is_a: GO:0008134 ! transcription factor binding
is_a: GO:0035257 ! nuclear hormone receptor binding

[Term]
id: GO:0042810
name: pheromone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
synonym: "pheromone metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0042445 ! hormone metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0042811
name: pheromone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pheromone anabolism" EXACT []
synonym: "pheromone biosynthesis" EXACT []
synonym: "pheromone formation" EXACT []
synonym: "pheromone synthesis" EXACT []
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0042810 ! pheromone metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0042812
name: pheromone catabolic process
namespace: biological_process
alt_id: GO:0007327
alt_id: GO:0046614
def: "The chemical reactions and pathways resulting in the breakdown of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pheromone breakdown" EXACT []
synonym: "pheromone catabolism" EXACT []
synonym: "pheromone degradation" EXACT []
is_a: GO:0042447 ! hormone catabolic process
is_a: GO:0042810 ! pheromone metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0042813
name: Wnt receptor activity
namespace: molecular_function
def: "Combining with a member of the Wnt family of signaling molecules to initiate a change in cell activity." [GOC:go_curators]
synonym: "frizzled receptor activity" RELATED []
synonym: "frizzled-2 receptor activity" RELATED []
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0042814
name: monopolar cell growth
namespace: biological_process
def: "Polarized growth from one end of a cell." [GOC:vw]
synonym: "monopolar cell elongation" NARROW []
synonym: "monopolar growth" BROAD []
synonym: "polar cell elongation" NARROW []
is_a: GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0042815
name: bipolar cell growth
namespace: biological_process
def: "Simultaneous polarized growth from opposite ends of a cell." [GOC:vw]
synonym: "bipolar cell elongation" NARROW []
synonym: "bipolar growth" BROAD []
synonym: "polar cell elongation" RELATED []
is_a: GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0042816
name: vitamin B6 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "vitamin B6 metabolism" EXACT []
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0042817
name: pyridoxal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:jl, http://www.mblab.gla.ac.uk/]
subset: gosubset_prok
synonym: "pyridoxal metabolism" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0042816 ! vitamin B6 metabolic process

[Term]
id: GO:0042818
name: pyridoxamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "pyridoxamine metabolism" EXACT []
is_a: GO:0042816 ! vitamin B6 metabolic process

[Term]
id: GO:0042819
name: vitamin B6 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "vitamin B6 anabolism" EXACT []
synonym: "vitamin B6 biosynthesis" EXACT []
synonym: "vitamin B6 formation" EXACT []
synonym: "vitamin B6 synthesis" EXACT []
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0042816 ! vitamin B6 metabolic process

[Term]
id: GO:0042820
name: vitamin B6 catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
subset: gosubset_prok
synonym: "vitamin B6 breakdown" EXACT []
synonym: "vitamin B6 catabolism" EXACT []
synonym: "vitamin B6 degradation" EXACT []
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0042816 ! vitamin B6 metabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0042821
name: pyridoxal biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds." [GOC:jl, http://www.mblab.gla.ac.uk/]
subset: gosubset_prok
synonym: "pyridoxal anabolism" EXACT []
synonym: "pyridoxal biosynthesis" EXACT []
synonym: "pyridoxal formation" EXACT []
synonym: "pyridoxal synthesis" EXACT []
is_a: GO:0042817 ! pyridoxal metabolic process
is_a: GO:0042819 ! vitamin B6 biosynthetic process

[Term]
id: GO:0042822
name: pyridoxal phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/]
subset: gosubset_prok
synonym: "active vitamin B6 metabolic process" EXACT []
synonym: "active vitamin B6 metabolism" EXACT []
synonym: "pyridoxal phosphate metabolism" EXACT []
is_a: GO:0042816 ! vitamin B6 metabolic process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0042823
name: pyridoxal phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/]
subset: gosubset_prok
synonym: "active vitamin B6 biosynthesis" EXACT []
synonym: "active vitamin B6 biosynthetic process" EXACT []
synonym: "pyridoxal phosphate anabolism" EXACT []
synonym: "pyridoxal phosphate biosynthesis" EXACT []
synonym: "pyridoxal phosphate formation" EXACT []
synonym: "pyridoxal phosphate synthesis" EXACT []
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0042819 ! vitamin B6 biosynthetic process
is_a: GO:0042822 ! pyridoxal phosphate metabolic process

[Term]
id: GO:0042824
name: MHC class I peptide loading complex
namespace: cellular_component
def: "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules." [GOC:jl, PMID:10631934]
comment: Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi.
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0042825
name: TAP complex
namespace: cellular_component
def: "A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum." [GOC:jl, PMID:10618487, PMID:10631934]
synonym: "transporter associated with antigen presentation" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0042824 ! MHC class I peptide loading complex

[Term]
id: GO:0042826
name: histone deacetylase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme histone deacetylase." [GOC:jl]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0042827
name: platelet dense granule
namespace: cellular_component
def: "Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:jl, http://www.mercksource.com/, PMID:10403682, PMID:11487378]
synonym: "bull's eye body" EXACT []
synonym: "platelet dense body" EXACT []
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0042832
name: defense response to protozoan
namespace: biological_process
def: "Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism." [GOC:jl]
synonym: "defence response to pathogenic protozoa" EXACT []
synonym: "defence response to protozoa" EXACT []
synonym: "defence response to protozoon" EXACT []
synonym: "defense response to pathogenic protozoa" EXACT []
synonym: "defense response to protozoa" EXACT []
synonym: "defense response to protozoon" EXACT []
is_a: GO:0001562 ! response to protozoan
is_a: GO:0006952 ! defense response

[Term]
id: GO:0042834
name: peptidoglycan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226]
subset: gosubset_prok
is_a: GO:0005539 ! glycosaminoglycan binding

[Term]
id: GO:0042835
name: BRE binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the RNA element BRE (Bruno response element)." [PMID:10893231]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0042836
name: D-glucarate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-glucarate, the D-enantiomer of glucarate. D-glucarate is derived from either D-glucose or L-gulose." [GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-glucarate metabolism" EXACT []
synonym: "saccharate metabolic process" EXACT []
synonym: "saccharate metabolism" EXACT []
is_a: GO:0019392 ! glucarate metabolic process

[Term]
id: GO:0042837
name: D-glucarate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-glucarate, the D-enantiomer of glucarate." [GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-glucarate anabolism" EXACT []
synonym: "D-glucarate biosynthesis" EXACT []
synonym: "D-glucarate formation" EXACT []
synonym: "D-glucarate synthesis" EXACT []
synonym: "saccharate biosynthesis" EXACT []
synonym: "saccharate biosynthetic process" EXACT []
is_a: GO:0019393 ! glucarate biosynthetic process
is_a: GO:0042836 ! D-glucarate metabolic process

[Term]
id: GO:0042838
name: D-glucarate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-glucarate, the D-enantiomer of glucarate." [GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-glucarate breakdown" EXACT []
synonym: "D-glucarate catabolism" EXACT []
synonym: "D-glucarate degradation" EXACT []
synonym: "saccharate catabolic process" EXACT []
synonym: "saccharate catabolism" EXACT []
is_a: GO:0019394 ! glucarate catabolic process
is_a: GO:0042836 ! D-glucarate metabolic process

[Term]
id: GO:0042839
name: D-glucuronate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-glucuronate metabolism" EXACT []
is_a: GO:0019585 ! glucuronate metabolic process

[Term]
id: GO:0042840
name: D-glucuronate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-glucuronate breakdown" EXACT []
synonym: "D-glucuronate catabolism" EXACT []
synonym: "D-glucuronate degradation" EXACT []
is_a: GO:0006064 ! glucuronate catabolic process
is_a: GO:0042839 ! D-glucuronate metabolic process

[Term]
id: GO:0042841
name: D-glucuronate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-glucuronate anabolism" EXACT []
synonym: "D-glucuronate biosynthesis" EXACT []
synonym: "D-glucuronate formation" EXACT []
synonym: "D-glucuronate synthesis" EXACT []
is_a: GO:0042839 ! D-glucuronate metabolic process
is_a: GO:0046399 ! glucuronate biosynthetic process

[Term]
id: GO:0042842
name: D-xylose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-xylose anabolism" EXACT []
synonym: "D-xylose biosynthesis" EXACT []
synonym: "D-xylose formation" EXACT []
synonym: "D-xylose synthesis" EXACT []
is_a: GO:0019322 ! pentose biosynthetic process
is_a: GO:0042732 ! D-xylose metabolic process

[Term]
id: GO:0042843
name: D-xylose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-xylose breakdown" EXACT []
synonym: "D-xylose catabolism" EXACT []
synonym: "D-xylose degradation" EXACT []
is_a: GO:0019323 ! pentose catabolic process
is_a: GO:0042732 ! D-xylose metabolic process

[Term]
id: GO:0042844
name: glycol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycol, any of a class of alcohols having 2 hydroxyl groups in each molecule." [http://www.cogsci.princeton.edu/~wn/]
subset: gosubset_prok
synonym: "dihydric alcohol metabolic process" BROAD []
synonym: "dihydric alcohol metabolism" BROAD []
synonym: "glycol metabolism" EXACT []
is_a: GO:0034311 ! diol metabolic process

[Term]
id: GO:0042845
name: glycol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycol, any of a class of alcohols having 2 hydroxyl groups in each molecule." [http://www.cogsci.princeton.edu/~wn/]
subset: gosubset_prok
synonym: "dihydric alcohol biosynthesis" BROAD []
synonym: "dihydric alcohol biosynthetic process" BROAD []
synonym: "glycol anabolism" EXACT []
synonym: "glycol biosynthesis" EXACT []
synonym: "glycol formation" EXACT []
synonym: "glycol synthesis" EXACT []
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0042844 ! glycol metabolic process

[Term]
id: GO:0042846
name: glycol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycol, any of a class of alcohols having 2 hydroxyl groups in each molecule." [http://www.cogsci.princeton.edu/~wn/]
subset: gosubset_prok
synonym: "dihydric alcohol catabolic process" BROAD []
synonym: "dihydric alcohol catabolism" BROAD []
synonym: "glycol breakdown" EXACT []
synonym: "glycol catabolism" EXACT []
synonym: "glycol degradation" EXACT []
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0042844 ! glycol metabolic process

[Term]
id: GO:0042847
name: sorbose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sorbose anabolism" EXACT []
synonym: "sorbose biosynthesis" EXACT []
synonym: "sorbose formation" EXACT []
synonym: "sorbose synthesis" EXACT []
is_a: GO:0019311 ! sorbose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0042848
name: sorbose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sorbose breakdown" EXACT []
synonym: "sorbose catabolism" EXACT []
synonym: "sorbose degradation" EXACT []
is_a: GO:0019311 ! sorbose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0042849
name: L-sorbose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol." [ChEBI:17266, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "L-sorbose anabolism" EXACT []
synonym: "L-sorbose biosynthesis" EXACT []
synonym: "L-sorbose formation" EXACT []
synonym: "L-sorbose synthesis" EXACT []
is_a: GO:0019312 ! L-sorbose metabolic process
is_a: GO:0042847 ! sorbose biosynthetic process

[Term]
id: GO:0042850
name: L-sorbose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose." [ChEBI:17266, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "L-sorbose breakdown" EXACT []
synonym: "L-sorbose catabolism" EXACT []
synonym: "L-sorbose degradation" EXACT []
is_a: GO:0019312 ! L-sorbose metabolic process
is_a: GO:0042848 ! sorbose catabolic process

[Term]
id: GO:0042851
name: L-alanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [ChEBI:16977, GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-alanine metabolism" EXACT []
is_a: GO:0006522 ! alanine metabolic process

[Term]
id: GO:0042852
name: L-alanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [ChEBI:16977, GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-alanine anabolism" EXACT []
synonym: "L-alanine biosynthesis" EXACT []
synonym: "L-alanine formation" EXACT []
synonym: "L-alanine synthesis" EXACT []
is_a: GO:0006523 ! alanine biosynthetic process
is_a: GO:0042851 ! L-alanine metabolic process

[Term]
id: GO:0042853
name: L-alanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [ChEBI:16977, GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-alanine breakdown" EXACT []
synonym: "L-alanine catabolism" EXACT []
synonym: "L-alanine degradation" EXACT []
is_a: GO:0006524 ! alanine catabolic process
is_a: GO:0042851 ! L-alanine metabolic process

[Term]
id: GO:0042854
name: eugenol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "4-allyl-2-methoxyphenol metabolic process" EXACT []
synonym: "4-allyl-2-methoxyphenol metabolism" EXACT []
synonym: "eugenic acid metabolic process" EXACT []
synonym: "eugenic acid metabolism" EXACT []
synonym: "eugenol metabolism" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0018958 ! phenol metabolic process

[Term]
id: GO:0042855
name: eugenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "4-allyl-2-methoxyphenol biosynthesis" EXACT []
synonym: "4-allyl-2-methoxyphenol biosynthetic process" EXACT []
synonym: "eugenic acid biosynthesis" EXACT []
synonym: "eugenic acid biosynthetic process" EXACT []
synonym: "eugenol anabolism" EXACT []
synonym: "eugenol biosynthesis" EXACT []
synonym: "eugenol formation" EXACT []
synonym: "eugenol synthesis" EXACT []
is_a: GO:0042854 ! eugenol metabolic process
is_a: GO:0046189 ! phenol biosynthetic process

[Term]
id: GO:0042856
name: eugenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "4-allyl-2-methoxyphenol catabolic process" EXACT []
synonym: "4-allyl-2-methoxyphenol catabolism" EXACT []
synonym: "eugenic acid catabolic process" EXACT []
synonym: "eugenic acid catabolism" EXACT []
synonym: "eugenol breakdown" EXACT []
synonym: "eugenol catabolism" EXACT []
synonym: "eugenol degradation" EXACT []
is_a: GO:0019336 ! phenol catabolic process
is_a: GO:0042854 ! eugenol metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process

[Term]
id: GO:0042857
name: chrysobactin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459]
subset: gosubset_prok
synonym: "chrysobactin metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process

[Term]
id: GO:0042858
name: chrysobactin biosynthetic process
namespace: biological_process
alt_id: GO:0031183
alt_id: GO:0031184
def: "The chemical reactions and pathways resulting in the formation of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459]
subset: gosubset_prok
synonym: "chrysobactin anabolism" EXACT []
synonym: "chrysobactin biosynthesis" EXACT []
synonym: "chrysobactin biosynthetic process, peptide formation" NARROW []
synonym: "chrysobactin biosynthetic process, peptide modification" NARROW []
synonym: "chrysobactin formation" EXACT []
synonym: "chrysobactin synthesis" EXACT []
is_a: GO:0019290 ! siderophore biosynthetic process
is_a: GO:0042857 ! chrysobactin metabolic process

[Term]
id: GO:0042859
name: chrysobactin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459]
subset: gosubset_prok
synonym: "chrysobactin breakdown" EXACT []
synonym: "chrysobactin catabolism" EXACT []
synonym: "chrysobactin degradation" EXACT []
is_a: GO:0042857 ! chrysobactin metabolic process
is_a: GO:0046215 ! siderophore catabolic process

[Term]
id: GO:0042860
name: achromobactin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541]
subset: gosubset_prok
synonym: "achromobactin metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process

[Term]
id: GO:0042861
name: achromobactin biosynthetic process
namespace: biological_process
alt_id: GO:0031181
alt_id: GO:0031182
def: "The chemical reactions and pathways resulting in the formation of achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541]
subset: gosubset_prok
synonym: "achromobactin anabolism" EXACT []
synonym: "achromobactin biosynthesis" EXACT []
synonym: "achromobactin biosynthetic process, peptide formation" NARROW []
synonym: "achromobactin biosynthetic process, peptide modification" NARROW []
synonym: "achromobactin formation" EXACT []
synonym: "achromobactin synthesis" EXACT []
is_a: GO:0019290 ! siderophore biosynthetic process
is_a: GO:0042860 ! achromobactin metabolic process

[Term]
id: GO:0042862
name: achromobactin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541]
subset: gosubset_prok
synonym: "achromobactin breakdown" EXACT []
synonym: "achromobactin catabolism" EXACT []
synonym: "achromobactin degradation" EXACT []
is_a: GO:0042860 ! achromobactin metabolic process
is_a: GO:0046215 ! siderophore catabolic process

[Term]
id: GO:0042863
name: pyochelin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030]
subset: gosubset_prok
synonym: "pyochelin metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process

[Term]
id: GO:0042864
name: pyochelin biosynthetic process
namespace: biological_process
alt_id: GO:0031187
alt_id: GO:0031188
def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030]
subset: gosubset_prok
synonym: "pyochelin anabolism" EXACT []
synonym: "pyochelin biosynthesis" EXACT []
synonym: "pyochelin biosynthetic process, peptide formation" NARROW []
synonym: "pyochelin biosynthetic process, peptide modification" NARROW []
synonym: "pyochelin formation" EXACT []
synonym: "pyochelin synthesis" EXACT []
is_a: GO:0019290 ! siderophore biosynthetic process
is_a: GO:0042863 ! pyochelin metabolic process

[Term]
id: GO:0042865
name: pyochelin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030]
subset: gosubset_prok
synonym: "pyochelin breakdown" EXACT []
synonym: "pyochelin catabolism" EXACT []
synonym: "pyochelin degradation" EXACT []
is_a: GO:0042863 ! pyochelin metabolic process
is_a: GO:0046215 ! siderophore catabolic process

[Term]
id: GO:0042866
name: pyruvate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate." [GOC:go_curators]
subset: gosubset_prok
synonym: "pyruvate anabolism" EXACT []
synonym: "pyruvate biosynthesis" EXACT []
synonym: "pyruvate formation" EXACT []
synonym: "pyruvate synthesis" EXACT []
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0042867
name: pyruvate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate." [GOC:go_curators]
subset: gosubset_prok
synonym: "pyruvate breakdown" EXACT []
synonym: "pyruvate catabolism" EXACT []
synonym: "pyruvate degradation" EXACT []
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0042868
name: antisense RNA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "antisense RNA metabolism" EXACT []
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0042869
name: aldarate transport
namespace: biological_process
def: "The directed movement of aldarate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0042870
name: D-glucarate transport
namespace: biological_process
def: "The directed movement of D-glucarate, the D-enantiomer of glucarate, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0042869 ! aldarate transport

[Term]
id: GO:0042871
name: D-galactarate transport
namespace: biological_process
def: "The directed movement of D-galactarate into, out of, within or between cells by means of some external agent such as a transporter or pore. D-galactarate is the D-enantiomer of galactarate, the anion of galactaric acid." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0042869 ! aldarate transport

[Term]
id: GO:0042872
name: D-galactarate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-galactarate, the D-enantiomer of the anion of galactaric acid." [GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-galactarate anabolism" EXACT []
synonym: "D-galactarate biosynthesis" EXACT []
synonym: "D-galactarate formation" EXACT []
synonym: "D-galactarate synthesis" EXACT []
is_a: GO:0046357 ! galactarate biosynthetic process
is_a: GO:0046393 ! D-galactarate metabolic process

[Term]
id: GO:0042873
name: aldonate transport
namespace: biological_process
def: "The directed movement of aldonate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl]
subset: gosubset_prok
is_a: GO:0008645 ! hexose transport

[Term]
id: GO:0042874
name: D-glucuronate transport
namespace: biological_process
def: "The directed movement of D-glucuronate, the D-enantiomer of glucuronate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]
is_a: GO:0042873 ! aldonate transport

[Term]
id: GO:0042875
name: D-galactonate transport
namespace: biological_process
def: "The directed movement of D-galactonate, the D-enantiomer of galactonate, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
is_a: GO:0042873 ! aldonate transport

[Term]
id: GO:0042876
name: aldarate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of aldarate from one side of the membrane to the other." [GOC:go_curators, PMID:15034926]
subset: gosubset_prok
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0042877
name: D-galactarate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of D-galactarate, the D-enantiomer of the anion of galactaric acid, from one side of the membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0042876 ! aldarate transmembrane transporter activity

[Term]
id: GO:0042878
name: D-glucarate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of D-glucarate, the D-enantiomer of glucarate, from one side of the membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0042876 ! aldarate transmembrane transporter activity

[Term]
id: GO:0042879
name: aldonate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of aldonate from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015149 ! hexose transmembrane transporter activity

[Term]
id: GO:0042880
name: D-glucuronate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of the membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0042879 ! aldonate transmembrane transporter activity

[Term]
id: GO:0042881
name: D-galactonate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of D-galactonate, the D-enantiomer of galactonate, from one side of the membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729]
is_a: GO:0042879 ! aldonate transmembrane transporter activity

[Term]
id: GO:0042882
name: L-arabinose transport
namespace: biological_process
def: "The directed movement of L-arabinose, the L-enantiomer of arabinose, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015751 ! arabinose transport

[Term]
id: GO:0042883
name: cysteine transport
namespace: biological_process
def: "The directed movement of cysteine into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "L-cysteine transport" NARROW []
is_a: GO:0000101 ! sulfur amino acid transport
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0042884
name: microcin transport
namespace: biological_process
def: "The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11292337]
subset: gosubset_prok
is_a: GO:0015833 ! peptide transport
is_a: GO:0042891 ! antibiotic transport

[Term]
id: GO:0042885
name: microcin B17 transport
namespace: biological_process
def: "The directed movement of microcin B17, a bactericidal peptide (antibiotic) produced by some enteric bacteria, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, PMID:11292337]
subset: gosubset_prok
is_a: GO:0042884 ! microcin transport

[Term]
id: GO:0042886
name: amide transport
namespace: biological_process
def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0042887
name: amide transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of the membrane to the other." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "amine/amide/polyamine channel activity" NARROW []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0042888
name: molybdenum ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of molybdenum (Mo) ions from one side of a membrane to the other." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0042889
name: 3-phenylpropionic acid transport
namespace: biological_process
def: "The directed movement of 3-phenylpropionic acid into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl]
subset: gosubset_prok
synonym: "3-phenylpropionate transport" EXACT []
synonym: "HCA transport" EXACT []
synonym: "hydrocinnamic acid transport" EXACT []
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0042890
name: 3-phenylpropionic acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of 3-phenylpropionic acid from one side of the membrane to the other." [GOC:jl]
synonym: "3-phenylpropionate acid transporter activity" EXACT []
synonym: "HCA transporter activity" EXACT []
synonym: "hydrocinnamic acid transporter activity" EXACT []
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0042891
name: antibiotic transport
namespace: biological_process
def: "The directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl]
subset: gosubset_prok
is_a: GO:0015893 ! drug transport

[Term]
id: GO:0042892
name: chloramphenicol transport
namespace: biological_process
def: "The directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0042891 ! antibiotic transport

[Term]
id: GO:0042893
name: polymyxin transport
namespace: biological_process
def: "The directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0042891 ! antibiotic transport

[Term]
id: GO:0042894
name: fosmidomycin transport
namespace: biological_process
def: "The directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, PMID:12543685]
subset: gosubset_prok
is_a: GO:0042891 ! antibiotic transport

[Term]
id: GO:0042895
name: antibiotic transporter activity
namespace: molecular_function
def: "Enables the directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of, within or between cells." [GOC:jl]
subset: gosubset_prok
is_a: GO:0015238 ! drug transmembrane transporter activity

[Term]
id: GO:0042896
name: chloramphenicol transporter activity
namespace: molecular_function
def: "Enables the directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0042895 ! antibiotic transporter activity

[Term]
id: GO:0042897
name: polymyxin transporter activity
namespace: molecular_function
def: "Enables the directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of, within or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0042895 ! antibiotic transporter activity

[Term]
id: GO:0042898
name: fosmidomycin transporter activity
namespace: molecular_function
def: "Enables the directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of, within or between cells." [GOC:jl, PMID:12543685]
subset: gosubset_prok
is_a: GO:0042895 ! antibiotic transporter activity

[Term]
id: GO:0042899
name: arabinose polymer transport
namespace: biological_process
def: "The directed movement of an arabinose polymer, a repeating chain of arabinose monomers, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl]
subset: gosubset_prok
is_a: GO:0015751 ! arabinose transport

[Term]
id: GO:0042900
name: arabinose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, http://cancerweb.ncl.ac.uk/, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015146 ! pentose transmembrane transporter activity

[Term]
id: GO:0042901
name: arabinose polymer transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of an arabinose polymer, a repeating chain of arabinose monomers, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0042900 ! arabinose transmembrane transporter activity

[Term]
id: GO:0042902
name: peptidoglycan-protein cross-linking via L-threonyl-pentaglycyl-murein
namespace: biological_process
def: "The process of linking a protein to peptidoglycan via a carboxy terminal threonine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan." [RESID:AA0345]
subset: gosubset_prok
xref: RESID:AA0345
is_a: GO:0018104 ! peptidoglycan-protein cross-linking
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0042903
name: tubulin deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate." [PMID:12024216, PMID:12486003]
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0033558 ! protein deacetylase activity

[Term]
id: GO:0042904
name: 9-cis-retinoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029]
subset: gosubset_prok
synonym: "9-cis-retinoic acid anabolism" EXACT []
synonym: "9-cis-retinoic acid biosynthesis" EXACT []
synonym: "9-cis-retinoic acid formation" EXACT []
synonym: "9-cis-retinoic acid synthesis" EXACT []
is_a: GO:0035238 ! vitamin A biosynthetic process
is_a: GO:0042905 ! 9-cis-retinoic acid metabolic process

[Term]
id: GO:0042905
name: 9-cis-retinoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029]
subset: gosubset_prok
synonym: "9-cis-retinoic acid metabolism" EXACT []
is_a: GO:0042573 ! retinoic acid metabolic process

[Term]
id: GO:0042906
name: xanthine transport
namespace: biological_process
def: "The directed movement of xanthine into, out of, within or between cells by means of some external agent such as a transporter or pore. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl]
is_a: GO:0006863 ! purine transport

[Term]
id: GO:0042907
name: xanthine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl]
is_a: GO:0005345 ! purine transmembrane transporter activity

[Term]
id: GO:0042908
name: xenobiotic transport
namespace: biological_process
def: "The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0042909
name: acridine transport
namespace: biological_process
def: "The directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of, within or between cells by means of some external agent such as a transporter or pore." [ChEBI:36420, GOC:jl, http://www.wikipedia.org/Acridine]
subset: gosubset_prok
is_a: GO:0042908 ! xenobiotic transport

[Term]
id: GO:0042910
name: xenobiotic transporter activity
namespace: molecular_function
def: "Enables the directed movement of a xenobiotic, a compound foreign to living organisms, into, out of, within or between cells." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0005215 ! transporter activity

[Term]
id: GO:0042911
name: acridine transporter activity
namespace: molecular_function
def: "Enables the directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0042910 ! xenobiotic transporter activity

[Term]
id: GO:0042912
name: colicin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, GOC:mtg_transport, http://cancerweb.ncl.ac.uk/, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0022885 ! bacteriocin transmembrane transporter activity

[Term]
id: GO:0042913
name: group A colicin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of group A colicins (colicins E1, E2, E3, A, K, and N) from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:9171417]
subset: gosubset_prok
is_a: GO:0042912 ! colicin transmembrane transporter activity

[Term]
id: GO:0042914
name: colicin transport
namespace: biological_process
def: "The directed movement of a colicin into, out of, within or between cells by means of some external agent such as a transporter or pore. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0043213 ! bacteriocin transport

[Term]
id: GO:0042915
name: group A colicin transport
namespace: biological_process
def: "The directed movement of group A colicins (colicins E1, E2, E3, A, K, and N) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, PMID:9171417]
subset: gosubset_prok
is_a: GO:0042914 ! colicin transport

[Term]
id: GO:0042916
name: alkylphosphonate transport
namespace: biological_process
def: "The directed movement of an alkylphosphonate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0015716 ! phosphonate transport

[Term]
id: GO:0042917
name: alkylphosphonate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of an alkylphosphonate from one side of a membrane to the other." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0015604 ! phosphonate transmembrane transporter activity

[Term]
id: GO:0042918
name: alkanesulfonate transport
namespace: biological_process
def: "The directed movement of an alkanesulfonate into, out of, within or between cells by means of some external agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "alkanesulphonate transport" EXACT []
is_a: GO:0042908 ! xenobiotic transport

[Term]
id: GO:0042919
name: benzoate transport
namespace: biological_process
def: "The directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
is_a: GO:0042908 ! xenobiotic transport

[Term]
id: GO:0042920
name: 3-hydroxyphenylpropionic acid transport
namespace: biological_process
def: "The directed movement of 3-hydroxyphenylpropionic acid into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators]
subset: gosubset_prok
synonym: "3-(3-hydroxyphenyl)propionic acid transport" EXACT []
synonym: "m-hydroxyphenylpropionic acid transport" EXACT []
is_a: GO:0042908 ! xenobiotic transport

[Term]
id: GO:0042921
name: glucocorticoid receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of a glucocorticoid binding to its receptor." [GOC:mah]
synonym: "glucocorticoid receptor signalling pathway" EXACT []
is_a: GO:0031958 ! corticosteroid receptor signaling pathway

[Term]
id: GO:0042922
name: neuromedin U receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with one or more specific sites on a neuromedin U receptor." [GOC:jl, PMID:10899166]
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0042923
name: neuropeptide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators)." [http://cancerweb.ncl.ac.uk/]
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0042924
name: neuromedin U binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses." [GOC:jl, PMID:12584108]
synonym: "NMU binding" EXACT []
is_a: GO:0042923 ! neuropeptide binding

[Term]
id: GO:0042925
name: benzoate transporter activity
namespace: molecular_function
def: "Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of, within or between cells." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
is_a: GO:0042910 ! xenobiotic transporter activity

[Term]
id: GO:0042926
name: 3-hydroxyphenylpropionic acid transporter activity
namespace: molecular_function
def: "Enables the directed movement of 3-hydroxyphenylpropionic acid into, out of, within or between cells." [GOC:jl]
subset: gosubset_prok
synonym: "3-(3-hydroxyphenyl)propionic acid transporter activity" EXACT []
synonym: "m-hydroxyphenylpropionic acid transporter activity" EXACT []
is_a: GO:0042910 ! xenobiotic transporter activity

[Term]
id: GO:0042927
name: siderophore transporter activity
namespace: molecular_function
def: "Enables the directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of, within or between cells." [GOC:go_curators]
subset: gosubset_prok
synonym: "siderochrome transporter activity" NARROW []
is_a: GO:0005215 ! transporter activity

[Term]
id: GO:0042928
name: ferrichrome transport
namespace: biological_process
def: "The directed movement of a ferrichrome into, out of, within or between cells by means of some external agent such as a transporter or pore. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015891 ! siderophore transport

[Term]
id: GO:0042929
name: ferrichrome transporter activity
namespace: molecular_function
def: "Enables the directed movement of a ferrichrome into, out of, within or between cells. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0042927 ! siderophore transporter activity

[Term]
id: GO:0042930
name: enterobactin transport
namespace: biological_process
def: "The directed movement of the siderochrome enterobactin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "enterochelin transport" EXACT []
is_a: GO:0015891 ! siderophore transport

[Term]
id: GO:0042931
name: enterobactin transporter activity
namespace: molecular_function
def: "Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "enterochelin transporter activity" EXACT []
is_a: GO:0042927 ! siderophore transporter activity

[Term]
id: GO:0042932
name: chrysobactin transport
namespace: biological_process
def: "The directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, PMID:8837459]
subset: gosubset_prok
is_a: GO:0015891 ! siderophore transport

[Term]
id: GO:0042933
name: chrysobactin transporter activity
namespace: molecular_function
def: "Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of, within or between cells." [GOC:jl, PMID:8837459]
subset: gosubset_prok
is_a: GO:0042927 ! siderophore transporter activity

[Term]
id: GO:0042934
name: achromobactin transporter activity
namespace: molecular_function
def: "Enables the directed movement of achromobactin, a citrate siderophore, into, out of, within or between cells." [GOC:jl]
subset: gosubset_prok
is_a: GO:0042927 ! siderophore transporter activity
is_a: GO:0051184 ! cofactor transporter activity

[Term]
id: GO:0042935
name: achromobactin transport
namespace: biological_process
def: "The directed movement of achromobactin, a citrate siderophore, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, PMID:10928541]
subset: gosubset_prok
is_a: GO:0015891 ! siderophore transport
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0042936
name: dipeptide transporter activity
namespace: molecular_function
def: "Enables the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0015198 ! oligopeptide transporter activity

[Term]
id: GO:0042937
name: tripeptide transporter activity
namespace: molecular_function
def: "Enables the directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of, within or between cells." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0015198 ! oligopeptide transporter activity

[Term]
id: GO:0042938
name: dipeptide transport
namespace: biological_process
def: "The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0006857 ! oligopeptide transport

[Term]
id: GO:0042939
name: tripeptide transport
namespace: biological_process
def: "The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0006857 ! oligopeptide transport

[Term]
id: GO:0042940
name: D-amino acid transport
namespace: biological_process
def: "The directed movement of the D-enantiomer of an amino acid into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0042941
name: D-alanine transport
namespace: biological_process
def: "The directed movement of D-alanine, the D-enantiomer of 2-aminopropanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [ChEBI:15570, GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
is_a: GO:0032328 ! alanine transport
is_a: GO:0042940 ! D-amino acid transport

[Term]
id: GO:0042942
name: D-serine transport
namespace: biological_process
def: "The directed movement of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
is_a: GO:0032329 ! serine transport
is_a: GO:0042940 ! D-amino acid transport

[Term]
id: GO:0042943
name: D-amino acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "D-amino acid transporter activity" BROAD []
is_a: GO:0015171 ! amino acid transmembrane transporter activity

[Term]
id: GO:0042944
name: D-alanine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of D-alanine from one side of a membrane to the other. D-alanine is the D-enantiomer of 2-aminopropanoic acid." [ChEBI:15570, GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "D-alanine transporter activity" BROAD []
is_a: GO:0022858 ! alanine transmembrane transporter activity
is_a: GO:0042943 ! D-amino acid transmembrane transporter activity

[Term]
id: GO:0042945
name: D-serine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "D-serine permease activity" EXACT []
synonym: "D-serine transporter activity" BROAD []
is_a: GO:0022889 ! serine transmembrane transporter activity
is_a: GO:0042943 ! D-amino acid transmembrane transporter activity

[Term]
id: GO:0042946
name: glucoside transport
namespace: biological_process
def: "The directed movement of glucosides into, out of, within or between cells by means of some external agent such as a transporter or pore. Glucosides are glycosides in which the sugar moiety is a glucose residue." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0042947
name: glucoside transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of glucosides from one side of the membrane to the other. Glucosides are glycosides in which the sugar moiety is a glucose residue." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0051119 ! sugar transmembrane transporter activity

[Term]
id: GO:0042948
name: salicin transport
namespace: biological_process
def: "The directed movement of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0015759 ! beta-glucoside transport

[Term]
id: GO:0042949
name: arbutin transport
namespace: biological_process
def: "The directed movement of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, http://biotech.icmb.utexas.edu/]
is_a: GO:0015759 ! beta-glucoside transport

[Term]
id: GO:0042950
name: salicin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, http://cancerweb.ncl.ac.uk/, ISBN:0815340729]
subset: gosubset_prok
is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity

[Term]
id: GO:0042951
name: arbutin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, http://biotech.icmb.utexas.edu/, ISBN:0815340729]
is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity

[Term]
id: GO:0042952
name: beta-ketoadipate pathway
namespace: biological_process
def: "A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates." [GOC:jl, PMID:8905091]
subset: gosubset_prok
synonym: "ortho-cleavage pathway" BROAD []
is_a: GO:0019439 ! aromatic compound catabolic process

[Term]
id: GO:0042953
name: lipoprotein transport
namespace: biological_process
def: "The directed movement of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015031 ! protein transport

[Term]
id: GO:0042954
name: lipoprotein transporter activity
namespace: molecular_function
def: "Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids, into, out of, within or between cells." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0008565 ! protein transporter activity

[Term]
id: GO:0042955
name: dextrin transport
namespace: biological_process
def: "The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, http://www.mercksource.com/]
subset: gosubset_prok
is_a: GO:0015774 ! polysaccharide transport

[Term]
id: GO:0042956
name: maltodextrin transport
namespace: biological_process
def: "The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, http://www.mercksource.com/]
subset: gosubset_prok
is_a: GO:0042955 ! dextrin transport

[Term]
id: GO:0042957
name: dextrin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of the membrane to the other." [GOC:jl, GOC:vk, http://www.mercksource.com/]
subset: gosubset_prok
is_a: GO:0015159 ! polysaccharide transmembrane transporter activity

[Term]
id: GO:0042958
name: maltodextrin transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of the membrane to the other." [GOC:jl, http://www.mercksource.com/, PMID:15034926]
subset: gosubset_prok
is_a: GO:0042957 ! dextrin transmembrane transporter activity

[Term]
id: GO:0042959
name: alkanesulfonate transporter activity
namespace: molecular_function
def: "Enables the directed movement of alkanesulfonate into, out of, within or between cells." [GOC:jl]
subset: gosubset_prok
synonym: "alkanesulphonate transporter activity" EXACT []
is_a: GO:0042910 ! xenobiotic transporter activity

[Term]
id: GO:0042960
name: antimonite secondary active transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:jl]
subset: gosubset_prok
synonym: "antimonite porter activity" RELATED []
is_a: GO:0015104 ! antimonite transmembrane transporter activity
is_a: GO:0015291 ! secondary active transmembrane transporter activity

[Term]
id: GO:0042961
name: antimonite-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out)." [EC:3.6.3.16]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "antimonite ABC transporter" NARROW []
is_a: GO:0042960 ! antimonite secondary active transmembrane transporter activity
is_a: GO:0043225 ! anion transmembrane-transporting ATPase activity

[Term]
id: GO:0042962
name: acridine:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out)." [PMID:10735876]
subset: gosubset_prok
synonym: "acridine efflux pump activity" RELATED []
synonym: "acridine:proton antiporter activity" EXACT []
is_a: GO:0015299 ! solute:hydrogen antiporter activity
is_a: GO:0042911 ! acridine transporter activity

[Term]
id: GO:0042963
name: phage assembly
namespace: biological_process
def: "A late phase of bacteriophage replication during which all the components necessary for the formation of a mature virion collect at a particular site in the bacterial cell and the basic structure of the virus particle is formed." [GOC:go_curators]
synonym: "bacteriophage assembly" EXACT []
is_a: GO:0019068 ! virion assembly

[Term]
id: GO:0042964
name: thioredoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thioredoxin, a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase." [GOC:go_curators]
subset: gosubset_prok
synonym: "thioredoxin anabolism" EXACT []
synonym: "thioredoxin biosynthesis" EXACT []
synonym: "thioredoxin formation" EXACT []
synonym: "thioredoxin synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0042965
name: glutaredoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:go_curators]
subset: gosubset_prok
synonym: "glutaredoxin anabolism" EXACT []
synonym: "glutaredoxin biosynthesis" EXACT []
synonym: "glutaredoxin formation" EXACT []
synonym: "glutaredoxin synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0042966
name: biotin carboxyl carrier protein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the biotin carboxyl carrier protein, a subunit of acetyl-coenzyme A carboxylase." [GOC:go_curators, PMID:8102363]
subset: gosubset_prok
synonym: "BCCP biosynthesis" EXACT []
synonym: "BCCP biosynthetic process" EXACT []
synonym: "biotin carboxyl carrier protein anabolism" EXACT []
synonym: "biotin carboxyl carrier protein biosynthesis" EXACT []
synonym: "biotin carboxyl carrier protein formation" EXACT []
synonym: "biotin carboxyl carrier protein synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0042967
name: acyl-carrier-protein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acyl-carrier protein." [GOC:go_curators]
subset: gosubset_prok
synonym: "ACP biosynthesis" EXACT []
synonym: "ACP biosynthetic process" EXACT []
synonym: "acyl carrier protein biosynthesis" EXACT []
synonym: "acyl carrier protein biosynthetic process" EXACT []
synonym: "acyl-carrier protein biosynthesis" EXACT []
synonym: "acyl-carrier-protein anabolism" EXACT []
synonym: "acyl-carrier-protein biosynthesis" EXACT []
synonym: "acyl-carrier-protein formation" EXACT []
synonym: "acyl-carrier-protein synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0042968
name: homoserine transport
namespace: biological_process
def: "The directed movement of homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015804 ! neutral amino acid transport

[Term]
id: GO:0042969
name: lactone transport
namespace: biological_process
def: "The directed movement of lactone, any of a series of organic compounds, regarded as anhydrides of certain hydroxy acids, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0042970
name: homoserine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "homoserine transporter activity" BROAD []
is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity

[Term]
id: GO:0042971
name: lactone transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of lactone, any of a series of organic compounds, regarded as anhydrides of certain hydroxy acids, from one side of a membrane to the other." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0042972
name: licheninase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of 1,4-beta-D-glucosidic linkages in beta-D-glucans containing 1,3- and 1,4-bonds." [EC:3.2.1.73]
subset: gosubset_prok
synonym: "1,3-1,4-beta-D-glucan 4-glucanohydrolase activity" EXACT []
synonym: "1,3-1,4-beta-glucan 4-glucanohydrolase activity" EXACT []
synonym: "1,3;1,4-beta-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.73]
synonym: "1,3;1,4-beta-glucan endohydrolase activity" EXACT [EC:3.2.1.73]
synonym: "beta-(1->3), (1->4)-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.73]
synonym: "beta-glucanase activity" BROAD [EC:3.2.1.73]
synonym: "endo-beta-1,3-1,4 glucanase activity" EXACT [EC:3.2.1.73]
synonym: "lichenase activity" EXACT []
synonym: "mixed linkage beta-glucanase activity" RELATED [EC:3.2.1.73]
xref: EC:3.2.1.73
xref: MetaCyc:3.2.1.73-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0042973
name: glucan endo-1,3-beta-D-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans." [EC:3.2.1.39]
subset: gosubset_prok
synonym: "(1->3)-beta-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.39]
synonym: "(1->3)-beta-glucan endohydrolase activity" EXACT [EC:3.2.1.39]
synonym: "1,3-beta-D-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.39]
synonym: "1,3-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.39]
synonym: "beta-1,3-glucanase" BROAD [EC:3.2.1.39]
synonym: "callase activity" EXACT [EC:3.2.1.39]
synonym: "endo-(1,3)-beta-D-glucanase activity" BROAD [EC:3.2.1.39]
synonym: "endo-(1->3)-beta-D-glucanase activity" BROAD [EC:3.2.1.39]
synonym: "endo-1,3-beta-D-glucanase" BROAD [EC:3.2.1.39]
synonym: "endo-1,3-beta-glucanase activity" BROAD []
synonym: "endo-1,3-beta-glucosidase activity" BROAD [EC:3.2.1.39]
synonym: "kitalase activity" EXACT [EC:3.2.1.39]
synonym: "laminaranase activity" BROAD []
synonym: "laminarinase activity" BROAD []
synonym: "oligo-1,3-glucosidase activity" RELATED [EC:3.2.1.39]
xref: EC:3.2.1.39
xref: MetaCyc:3.2.1.39-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0042974
name: retinoic acid receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily." [GOC:jl, PMID:12476796]
synonym: "RAR binding" EXACT []
is_a: GO:0008134 ! transcription factor binding
is_a: GO:0035257 ! nuclear hormone receptor binding

[Term]
id: GO:0042975
name: peroxisome proliferator activated receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma." [GOC:jl, PMID:12769781]
synonym: "PPAR binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0042976
name: activation of Janus kinase activity
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:jl, PMID:12479803]
synonym: "activation of JAK protein" EXACT [GOC:dph, GOC:tb]
synonym: "activation of JAK protein by tyrosine phosphorylation" EXACT []
synonym: "positive regulation of JAK protein activity by tyrosine phosphorylation" BROAD []
synonym: "tyrosine phosphorylation of JAK protein" RELATED []
is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation
is_a: GO:0032147 ! activation of protein kinase activity
relationship: part_of GO:0007259 ! JAK-STAT cascade

[Term]
id: GO:0042977
name: activation of JAK2 kinase activity
namespace: biological_process
def: "The process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:jl, PMID:12479803]
synonym: "activation of JAK2 protein" EXACT [GOC:dph, GOC:tb]
synonym: "tyrosine phosphorylation of JAK2 protein" RELATED []
is_a: GO:0042976 ! activation of Janus kinase activity

[Term]
id: GO:0042978
name: ornithine decarboxylase activator activity
namespace: molecular_function
def: "Upregulation of the activity of the enzyme ornithine decarboxylase." [GOC:jl]
synonym: "L-ornithine carboxy-lyase activator activity" NARROW []
is_a: GO:0008047 ! enzyme activator activity
is_a: GO:0042979 ! ornithine decarboxylase regulator activity

[Term]
id: GO:0042979
name: ornithine decarboxylase regulator activity
namespace: molecular_function
def: "Modulation of the activity of the enzyme ornithine decarboxylase." [GOC:jl]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0042980
name: cystic fibrosis transmembrane conductance regulator binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein." [GOC:jl]
synonym: "CFTR binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0042981
name: regulation of apoptosis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptosis." [GOC:jl]
synonym: "apoptosis regulator activity" RELATED []
xref: Reactome:169911 "Regulation of Apoptosis"
xref: Reactome:449161 "Regulation of Apoptosis"
xref: Reactome:470385 "Regulation of Apoptosis"
xref: Reactome:508024 "Regulation of Apoptosis"
xref: Reactome:517884 "Regulation of Apoptosis"
xref: Reactome:526707 "Regulation of Apoptosis"
xref: Reactome:531482 "Regulation of Apoptosis"
xref: Reactome:536867 "Regulation of Apoptosis"
xref: Reactome:542621 "Regulation of Apoptosis"
xref: Reactome:547937 "Regulation of Apoptosis"
xref: Reactome:552513 "Regulation of Apoptosis"
xref: Reactome:586019 "Regulation of Apoptosis"
xref: Reactome:592874 "Regulation of Apoptosis"
is_a: GO:0043067 ! regulation of programmed cell death
relationship: regulates GO:0006915 ! apoptosis

[Term]
id: GO:0042982
name: amyloid precursor protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators]
subset: gosubset_prok
synonym: "amyloid precursor protein metabolism" EXACT []
synonym: "APP metabolic process" EXACT []
synonym: "APP metabolism" EXACT []
is_a: GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:0042983
name: amyloid precursor protein biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators]
subset: gosubset_prok
synonym: "amyloid precursor protein anabolism" EXACT []
synonym: "amyloid precursor protein biosynthesis" EXACT []
synonym: "amyloid precursor protein formation" EXACT []
synonym: "amyloid precursor protein synthesis" EXACT []
synonym: "APP biosynthesis" EXACT []
synonym: "APP biosynthetic process" EXACT []
is_a: GO:0009101 ! glycoprotein biosynthetic process
is_a: GO:0042982 ! amyloid precursor protein metabolic process

[Term]
id: GO:0042984
name: regulation of amyloid precursor protein biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of amyloid precursor protein anabolism" EXACT []
synonym: "regulation of amyloid precursor protein biosynthesis" EXACT []
synonym: "regulation of amyloid precursor protein formation" EXACT []
synonym: "regulation of amyloid precursor protein synthesis" EXACT []
synonym: "regulation of APP biosynthesis" EXACT []
synonym: "regulation of APP biosynthetic process" EXACT []
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
relationship: regulates GO:0042983 ! amyloid precursor protein biosynthetic process

[Term]
id: GO:0042985
name: negative regulation of amyloid precursor protein biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of amyloid precursor protein biosynthetic process" EXACT []
synonym: "down-regulation of amyloid precursor protein biosynthetic process" EXACT []
synonym: "downregulation of amyloid precursor protein biosynthetic process" EXACT []
synonym: "inhibition of amyloid precursor protein biosynthetic process" NARROW []
synonym: "negative regulation of amyloid precursor protein anabolism" EXACT []
synonym: "negative regulation of amyloid precursor protein biosynthesis" EXACT []
synonym: "negative regulation of amyloid precursor protein formation" EXACT []
synonym: "negative regulation of amyloid precursor protein synthesis" EXACT []
synonym: "negative regulation of APP biosynthesis" EXACT []
synonym: "negative regulation of APP biosynthetic process" EXACT []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0042984 ! regulation of amyloid precursor protein biosynthetic process
relationship: negatively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process

[Term]
id: GO:0042986
name: positive regulation of amyloid precursor protein biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of amyloid precursor protein biosynthetic process" NARROW []
synonym: "positive regulation of amyloid precursor protein anabolism" EXACT []
synonym: "positive regulation of amyloid precursor protein biosynthesis" EXACT []
synonym: "positive regulation of amyloid precursor protein formation" EXACT []
synonym: "positive regulation of amyloid precursor protein synthesis" EXACT []
synonym: "positive regulation of APP biosynthesis" EXACT []
synonym: "positive regulation of APP biosynthetic process" EXACT []
synonym: "stimulation of amyloid precursor protein biosynthetic process" NARROW []
synonym: "up regulation of amyloid precursor protein biosynthetic process" EXACT []
synonym: "up-regulation of amyloid precursor protein biosynthetic process" EXACT []
synonym: "upregulation of amyloid precursor protein biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0042984 ! regulation of amyloid precursor protein biosynthetic process
relationship: positively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process

[Term]
id: GO:0042987
name: amyloid precursor protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators]
synonym: "amyloid precursor protein breakdown" EXACT []
synonym: "amyloid precursor protein catabolism" EXACT []
synonym: "amyloid precursor protein degradation" EXACT []
synonym: "APP catabolic process" EXACT []
synonym: "APP catabolism" EXACT []
is_a: GO:0006516 ! glycoprotein catabolic process
is_a: GO:0042982 ! amyloid precursor protein metabolic process

[Term]
id: GO:0042988
name: X11-like protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with X11-like protein, a neuron-specific adaptor protein." [GOC:jl, PMID:12780348]
synonym: "X11L binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0042989
name: sequestering of actin monomers
namespace: biological_process
def: "The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers." [GOC:go_curators]
synonym: "actin monomer retention" EXACT []
synonym: "actin monomer sequestering" EXACT []
synonym: "actin monomer sequestering activity" RELATED []
synonym: "actin monomer sequestration" EXACT []
synonym: "actin monomer storage" EXACT []
synonym: "retention of actin monomers" EXACT []
synonym: "sequestration of actin monomers" EXACT []
synonym: "storage of actin monomers" EXACT []
is_a: GO:0030837 ! negative regulation of actin filament polymerization
is_a: GO:0045185 ! maintenance of protein location

[Term]
id: GO:0042990
name: regulation of transcription factor import into nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl]
synonym: "regulation of transcription factor import into cell nucleus" EXACT []
synonym: "regulation of transcription factor transport from cytoplasm to nucleus" EXACT []
synonym: "regulation of transcription factor-nucleus import" EXACT []
is_a: GO:0042306 ! regulation of protein import into nucleus
relationship: regulates GO:0042991 ! transcription factor import into nucleus

[Term]
id: GO:0042991
name: transcription factor import into nucleus
namespace: biological_process
def: "The directed movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl]
synonym: "transcription factor import into cell nucleus" EXACT []
synonym: "transcription factor transport from cytoplasm to nucleus" EXACT []
synonym: "transcription factor-nucleus import" EXACT []
is_a: GO:0006606 ! protein import into nucleus

[Term]
id: GO:0042992
name: negative regulation of transcription factor import into nucleus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl]
synonym: "down regulation of transcription factor import into nucleus" EXACT []
synonym: "down-regulation of transcription factor import into nucleus" EXACT []
synonym: "downregulation of transcription factor import into nucleus" EXACT []
synonym: "inhibition of transcription factor import into nucleus" NARROW []
synonym: "negative regulation of transcription factor import into cell nucleus" EXACT []
synonym: "negative regulation of transcription factor transport from cytoplasm to nucleus" EXACT []
synonym: "negative regulation of transcription factor-nucleus import" EXACT []
is_a: GO:0042308 ! negative regulation of protein import into nucleus
is_a: GO:0042990 ! regulation of transcription factor import into nucleus
relationship: negatively_regulates GO:0042991 ! transcription factor import into nucleus

[Term]
id: GO:0042993
name: positive regulation of transcription factor import into nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl]
synonym: "activation of transcription factor import into nucleus" NARROW []
synonym: "positive regulation of transcription factor import into cell nucleus" EXACT []
synonym: "positive regulation of transcription factor transport from cytoplasm to nucleus" EXACT []
synonym: "positive regulation of transcription factor-nucleus import" EXACT []
synonym: "stimulation of transcription factor import into nucleus" NARROW []
synonym: "up regulation of transcription factor import into nucleus" EXACT []
synonym: "up-regulation of transcription factor import into nucleus" EXACT []
synonym: "upregulation of transcription factor import into nucleus" EXACT []
is_a: GO:0042307 ! positive regulation of protein import into nucleus
is_a: GO:0042990 ! regulation of transcription factor import into nucleus
relationship: positively_regulates GO:0042991 ! transcription factor import into nucleus

[Term]
id: GO:0042994
name: cytoplasmic sequestering of transcription factor
namespace: biological_process
def: "The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl]
synonym: "cytoplasmic retention of transcription factor" EXACT []
synonym: "cytoplasmic sequestration of transcription factor" EXACT []
synonym: "cytoplasmic storage of transcription factor" EXACT []
synonym: "maintenance of transcription factor protein location in cytoplasm" EXACT [GOC:dph, GOC:tb]
synonym: "retention of transcription factor in cytoplasm" EXACT []
synonym: "sequestering of transcription factor in cytoplasm" EXACT []
synonym: "sequestration of transcription factor in cytoplasm" EXACT []
synonym: "storage of transcription factor in cytoplasm" EXACT []
synonym: "transcription factor binding, cytoplasmic sequestering" EXACT []
is_a: GO:0042992 ! negative regulation of transcription factor import into nucleus
is_a: GO:0051220 ! cytoplasmic sequestering of protein

[Term]
id: GO:0042995
name: cell projection
namespace: cellular_component
def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
subset: goslim_pir
subset: gosubset_prok
synonym: "cell process" BROAD []
synonym: "cellular process" BROAD []
synonym: "cellular projection" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0042996
name: regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0060627 ! regulation of vesicle-mediated transport
relationship: regulates GO:0043001 ! Golgi to plasma membrane protein transport

[Term]
id: GO:0042997
name: negative regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]
synonym: "down regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "down-regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "downregulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "inhibition of Golgi to plasma membrane protein transport" NARROW []
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051224 ! negative regulation of protein transport
relationship: negatively_regulates GO:0043001 ! Golgi to plasma membrane protein transport

[Term]
id: GO:0042998
name: positive regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]
synonym: "activation of Golgi to plasma membrane protein transport" NARROW []
synonym: "stimulation of Golgi to plasma membrane protein transport" NARROW []
synonym: "up regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "up-regulation of Golgi to plasma membrane protein transport" EXACT []
synonym: "upregulation of Golgi to plasma membrane protein transport" EXACT []
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051222 ! positive regulation of protein transport
relationship: positively_regulates GO:0043001 ! Golgi to plasma membrane protein transport

[Term]
id: GO:0042999
name: regulation of Golgi to plasma membrane CFTR protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]
is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport
relationship: regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport

[Term]
id: GO:0043000
name: Golgi to plasma membrane CFTR protein transport
namespace: biological_process
def: "The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]
synonym: "Golgi to plasma membrane cystic fibrosis transmembrane conductance regulator protein transport" EXACT []
is_a: GO:0043001 ! Golgi to plasma membrane protein transport

[Term]
id: GO:0043001
name: Golgi to plasma membrane protein transport
namespace: biological_process
def: "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0006893 ! Golgi to plasma membrane transport

[Term]
id: GO:0043002
name: negative regulation of Golgi to plasma membrane CFTR protein transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]
synonym: "down regulation of Golgi to plasma membrane CFTR protein transport" EXACT []
synonym: "down-regulation of Golgi to plasma membrane CFTR protein transport" EXACT []
synonym: "downregulation of Golgi to plasma membrane CFTR protein transport" EXACT []
synonym: "inhibition of Golgi to plasma membrane CFTR protein transport" NARROW []
is_a: GO:0042997 ! negative regulation of Golgi to plasma membrane protein transport
is_a: GO:0042999 ! regulation of Golgi to plasma membrane CFTR protein transport
relationship: negatively_regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport

[Term]
id: GO:0043003
name: positive regulation of Golgi to plasma membrane CFTR protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]
synonym: "activation of Golgi to plasma membrane CFTR protein transport" NARROW []
synonym: "stimulation of Golgi to plasma membrane CFTR protein transport" NARROW []
synonym: "up regulation of Golgi to plasma membrane CFTR protein transport" EXACT []
synonym: "up-regulation of Golgi to plasma membrane CFTR protein transport" EXACT []
synonym: "upregulation of Golgi to plasma membrane CFTR protein transport" EXACT []
is_a: GO:0042998 ! positive regulation of Golgi to plasma membrane protein transport
is_a: GO:0042999 ! regulation of Golgi to plasma membrane CFTR protein transport
relationship: positively_regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport

[Term]
id: GO:0043004
name: cytoplasmic sequestering of CFTR protein
namespace: biological_process
def: "The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane." [GOC:jl]
synonym: "cytoplasmic retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein" EXACT []
synonym: "cytoplasmic sequestering of cystic fibrosis transmembrane conductance regulator protein" EXACT []
synonym: "cytoplasmic sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein)" EXACT []
synonym: "cytoplasmic storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein" EXACT []
synonym: "maintenance of CFTR protein location in cytoplasm" EXACT [GOC:dph, GOC:tb]
synonym: "retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm" EXACT []
synonym: "sequestering of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm" EXACT []
synonym: "sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm" EXACT []
synonym: "storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm" EXACT []
is_a: GO:0043002 ! negative regulation of Golgi to plasma membrane CFTR protein transport
is_a: GO:0051220 ! cytoplasmic sequestering of protein

[Term]
id: GO:0043005
name: neuron projection
namespace: cellular_component
def: "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
subset: goslim_pir
synonym: "neurite" NARROW []
synonym: "neuron process" EXACT []
synonym: "neuron protrusion" EXACT []
synonym: "neuronal cell projection" EXACT []
xref: NIF_Subcellular:sao-867568886
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0043006
name: activation of phospholipase A2 activity by calcium-mediated signaling
namespace: biological_process
def: "A series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal." [GOC:dph, GOC:jl, GOC:tb]
synonym: "activation of phospholipase A2 activity by calcium-mediated signalling" EXACT [GOC:mah]
synonym: "calcium-dependent activation of phospholipase A2" EXACT [GOC:dph, GOC:tb]
synonym: "calcium-dependent phospholipase A2 activation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0019722 ! calcium-mediated signaling
is_a: GO:0032431 ! activation of phospholipase A2 activity

[Term]
id: GO:0043007
name: maintenance of rDNA
namespace: biological_process
def: "Any process involved in sustaining the fidelity and copy number of rDNA repeats." [GOC:vw, PMID:14528010]
synonym: "rDNA maintenance" EXACT []
synonym: "ribosomal DNA maintenance" EXACT []
is_a: GO:0043570 ! maintenance of DNA repeat elements

[Term]
id: GO:0043008
name: ATP-dependent protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP." [GOC:jl]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043009
name: chordate embryonic development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu]
is_a: GO:0009792 ! embryonic development ending in birth or egg hatching

[Term]
id: GO:0043010
name: camera-type eye development
namespace: biological_process
alt_id: GO:0001747
alt_id: GO:0031075
def: "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:go_curators, GOC:mtg_sensu]
is_a: GO:0001654 ! eye development

[Term]
id: GO:0043011
name: myeloid dendritic cell differentiation
namespace: biological_process
def: "The process by which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin." [GOC:jl, http://cancerweb.ncl.ac.uk, Wikipedia:Dendritic_cell]
synonym: "Langerhans cell differentiation" EXACT []
is_a: GO:0001773 ! myeloid dendritic cell activation
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0043012
name: regulation of fusion of sperm to egg plasma membrane
namespace: biological_process
def: "Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html]
synonym: "regulation of sperm-oocyte fusion" NARROW []
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0007342 ! fusion of sperm to egg plasma membrane

[Term]
id: GO:0043013
name: negative regulation of fusion of sperm to egg plasma membrane
namespace: biological_process
def: "Any process that stops or prevents the binding and fusion of a sperm to the oocyte plasma membrane." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html]
synonym: "down regulation of fusion of sperm to egg plasma membrane" EXACT []
synonym: "down-regulation of fusion of sperm to egg plasma membrane" EXACT []
synonym: "downregulation of fusion of sperm to egg plasma membrane" EXACT []
synonym: "inhibition of fusion of sperm to egg plasma membrane" NARROW []
synonym: "inhibition of sperm-oocyte fusion" NARROW []
synonym: "negative regulation of sperm-oocyte fusion" NARROW []
is_a: GO:0043012 ! regulation of fusion of sperm to egg plasma membrane
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0007342 ! fusion of sperm to egg plasma membrane

[Term]
id: GO:0043014
name: alpha-tubulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin." [GOC:jl]
synonym: "alpha tubulin binding" EXACT []
is_a: GO:0015631 ! tubulin binding

[Term]
id: GO:0043015
name: gamma-tubulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin." [GOC:jl]
synonym: "gamma tubulin binding" EXACT []
is_a: GO:0015631 ! tubulin binding

[Term]
id: GO:0043016
name: regulation of lymphotoxin A biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl]
synonym: "regulation of LTA biosynthesis" EXACT []
synonym: "regulation of LTA biosynthetic process" EXACT []
synonym: "regulation of lymphotoxin A anabolism" EXACT []
synonym: "regulation of lymphotoxin A biosynthesis" EXACT []
synonym: "regulation of lymphotoxin A formation" EXACT []
synonym: "regulation of lymphotoxin A synthesis" EXACT []
synonym: "regulation of lymphotoxin-alpha biosynthesis" EXACT []
synonym: "regulation of lymphotoxin-alpha biosynthetic process" EXACT []
synonym: "regulation of TNF-B biosynthesis" EXACT []
synonym: "regulation of TNF-B biosynthetic process" EXACT []
synonym: "regulation of TNF-beta biosynthesis" EXACT []
synonym: "regulation of TNF-beta biosynthetic process" EXACT []
synonym: "regulation of tumor necrosis factor-beta biosynthesis" EXACT []
synonym: "regulation of tumor necrosis factor-beta biosynthetic process" EXACT []
is_a: GO:0032681 ! regulation of lymphotoxin A production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042109 ! lymphotoxin A biosynthetic process

[Term]
id: GO:0043017
name: positive regulation of lymphotoxin A biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl]
synonym: "activation of lymphotoxin A biosynthetic process" NARROW []
synonym: "positive regulation of LTA biosynthesis" EXACT []
synonym: "positive regulation of LTA biosynthetic process" EXACT []
synonym: "positive regulation of lymphotoxin A anabolism" EXACT []
synonym: "positive regulation of lymphotoxin A biosynthesis" EXACT []
synonym: "positive regulation of lymphotoxin A formation" EXACT []
synonym: "positive regulation of lymphotoxin A synthesis" EXACT []
synonym: "positive regulation of lymphotoxin-alpha biosynthesis" EXACT []
synonym: "positive regulation of lymphotoxin-alpha biosynthetic process" EXACT []
synonym: "positive regulation of TNF-B biosynthesis" EXACT []
synonym: "positive regulation of TNF-B biosynthetic process" EXACT []
synonym: "positive regulation of TNF-beta biosynthesis" EXACT []
synonym: "positive regulation of TNF-beta biosynthetic process" EXACT []
synonym: "positive regulation of tumor necrosis factor-beta biosynthesis" EXACT []
synonym: "positive regulation of tumor necrosis factor-beta biosynthetic process" EXACT []
synonym: "stimulation of lymphotoxin A biosynthetic process" NARROW []
synonym: "up regulation of lymphotoxin A biosynthetic process" EXACT []
synonym: "up-regulation of lymphotoxin A biosynthetic process" EXACT []
synonym: "upregulation of lymphotoxin A biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0043016 ! regulation of lymphotoxin A biosynthetic process
relationship: positively_regulates GO:0042109 ! lymphotoxin A biosynthetic process

[Term]
id: GO:0043018
name: negative regulation of lymphotoxin A biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl]
synonym: "down regulation of lymphotoxin A biosynthetic process" EXACT []
synonym: "down-regulation of lymphotoxin A biosynthetic process" EXACT []
synonym: "downregulation of lymphotoxin A biosynthetic process" EXACT []
synonym: "inhibition of lymphotoxin A biosynthetic process" NARROW []
synonym: "negative regulation of LTA biosynthesis" EXACT []
synonym: "negative regulation of LTA biosynthetic process" EXACT []
synonym: "negative regulation of lymphotoxin A anabolism" EXACT []
synonym: "negative regulation of lymphotoxin A biosynthesis" EXACT []
synonym: "negative regulation of lymphotoxin A formation" EXACT []
synonym: "negative regulation of lymphotoxin A synthesis" EXACT []
synonym: "negative regulation of lymphotoxin-alpha biosynthesis" EXACT []
synonym: "negative regulation of lymphotoxin-alpha biosynthetic process" EXACT []
synonym: "negative regulation of TNF-B biosynthesis" EXACT []
synonym: "negative regulation of TNF-B biosynthetic process" EXACT []
synonym: "negative regulation of TNF-beta biosynthesis" EXACT []
synonym: "negative regulation of TNF-beta biosynthetic process" EXACT []
synonym: "negative regulation of tumor necrosis factor-beta biosynthesis" EXACT []
synonym: "negative regulation of tumor necrosis factor-beta biosynthetic process" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0043016 ! regulation of lymphotoxin A biosynthetic process
relationship: negatively_regulates GO:0042109 ! lymphotoxin A biosynthetic process

[Term]
id: GO:0043020
name: NADPH oxidase complex
namespace: cellular_component
def: "A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2." [GOC:jl, PMID:11483596, PMID:12440767]
synonym: "flavocytochrome b558" NARROW []
synonym: "respiratory-burst oxidase" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0043021
name: ribonucleoprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any complex of RNA and protein." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "RNP binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0043022
name: ribosome binding
namespace: molecular_function
alt_id: GO:0030376
def: "Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators]
subset: gosubset_prok
synonym: "ribosome receptor activity" NARROW []
is_a: GO:0043021 ! ribonucleoprotein binding

[Term]
id: GO:0043023
name: ribosomal large subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of the larger ribosomal subunit." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0043021 ! ribonucleoprotein binding

[Term]
id: GO:0043024
name: ribosomal small subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of the small ribosomal subunit." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0043021 ! ribonucleoprotein binding

[Term]
id: GO:0043025
name: neuronal cell body
namespace: cellular_component
def: "The portion of a neuron that includes the nucleus, but excludes all cell projections such as axons and dendrites." [GOC:go_curators]
comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
subset: goslim_pir
synonym: "neuron cell body" EXACT []
synonym: "neuronal cell soma" EXACT []
xref: NIF_Subcellular:sao1044911821
xref: Wikipedia:Soma_(biology)
is_a: GO:0044297 ! cell body

[Term]
id: GO:0043027
name: caspase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:jl, Wikipedia:Caspase]
is_a: GO:0004869 ! cysteine-type endopeptidase inhibitor activity
is_a: GO:0043028 ! caspase regulator activity

[Term]
id: GO:0043028
name: caspase regulator activity
namespace: molecular_function
def: "Modulates the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:jl, Wikipedia:Caspase]
xref: Reactome:139818 "caspase regulator activity"
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0043029
name: T cell homeostasis
namespace: biological_process
def: "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus.
synonym: "T lymphocyte homeostasis" EXACT []
synonym: "T-cell homeostasis" EXACT []
synonym: "T-lymphocyte homeostasis" EXACT []
is_a: GO:0002260 ! lymphocyte homeostasis

[Term]
id: GO:0043030
name: regulation of macrophage activation
namespace: biological_process
def: "Any process that modulates the frequency or rate of macrophage activation." [GOC:jl]
is_a: GO:0002694 ! regulation of leukocyte activation
relationship: regulates GO:0042116 ! macrophage activation

[Term]
id: GO:0043031
name: negative regulation of macrophage activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage activation." [GOC:jl]
synonym: "down regulation of macrophage activation" EXACT []
synonym: "down-regulation of macrophage activation" EXACT []
synonym: "downregulation of macrophage activation" EXACT []
synonym: "inhibition of macrophage activation" NARROW []
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0043030 ! regulation of macrophage activation
relationship: negatively_regulates GO:0042116 ! macrophage activation

[Term]
id: GO:0043032
name: positive regulation of macrophage activation
namespace: biological_process
def: "Any process that stimulates, induces or increases the rate of macrophage activation." [GOC:jl]
synonym: "activation of macrophage activation" NARROW []
synonym: "stimulation of macrophage activation" NARROW []
synonym: "up regulation of macrophage activation" EXACT []
synonym: "up-regulation of macrophage activation" EXACT []
synonym: "upregulation of macrophage activation" EXACT []
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0043030 ! regulation of macrophage activation
relationship: positively_regulates GO:0042116 ! macrophage activation

[Term]
id: GO:0043033
name: isoamylase complex
namespace: cellular_component
def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages." [GOC:jl, PMID:10333591]
subset: goslim_pir
subset: gosubset_prok
synonym: "debranching enzyme complex" BROAD []
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0043034
name: costamere
namespace: cellular_component
def: "Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix." [GOC:jl, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:6405378]
xref: Wikipedia:Costamere
is_a: GO:0044449 ! contractile fiber part
relationship: part_of GO:0030016 ! myofibril

[Term]
id: GO:0043035
name: chromatin insulator sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795]
is_a: GO:0031490 ! chromatin DNA binding

[Term]
id: GO:0043036
name: starch grain
namespace: cellular_component
def: "Plant storage body for amylose and amylopectin, 1-100um in diameter. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978]
synonym: "starch granule" EXACT []
is_a: GO:0044435 ! plastid part

[Term]
id: GO:0043038
name: amino acid activation
namespace: biological_process
def: "The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule." [GOC:jl]
subset: gosubset_prok
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0043039
name: tRNA aminoacylation
namespace: biological_process
def: "The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]
subset: gosubset_prok
synonym: "aminoacyl-tRNA biosynthesis" EXACT [GOC:mah]
synonym: "aminoacyl-tRNA biosynthetic process" EXACT [GOC:mah]
synonym: "tRNA charging" EXACT []
is_a: GO:0006399 ! tRNA metabolic process
is_a: GO:0043038 ! amino acid activation

[Term]
id: GO:0043040
name: tRNA aminoacylation for nonribosomal peptide biosynthetic process
namespace: biological_process
def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in nonribosomal peptide synthesis." [GOC:jl]
subset: gosubset_prok
synonym: "tRNA aminoacylation for nonribosomal peptide anabolism" EXACT []
synonym: "tRNA aminoacylation for nonribosomal peptide biosynthesis" EXACT []
synonym: "tRNA aminoacylation for nonribosomal peptide formation" EXACT []
synonym: "tRNA aminoacylation for nonribosomal peptide synthesis" EXACT []
is_a: GO:0043039 ! tRNA aminoacylation
is_a: GO:0043041 ! amino acid activation for nonribosomal peptide biosynthetic process

[Term]
id: GO:0043041
name: amino acid activation for nonribosomal peptide biosynthetic process
namespace: biological_process
def: "Activation of an amino acid for incorporation into a peptide by a nonribosomal process." [GOC:jl]
subset: gosubset_prok
synonym: "nonribosomal amino acid activation" RELATED []
is_a: GO:0043038 ! amino acid activation
relationship: part_of GO:0019184 ! nonribosomal peptide biosynthetic process

[Term]
id: GO:0043042
name: amino acid adenylylation by nonribosomal peptide synthase
namespace: biological_process
def: "Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor." [GOC:jl, PMID:9250661, PMID:9712910]
subset: gosubset_prok
synonym: "amino acid adenylation by nonribosomal peptide synthase" EXACT []
synonym: "amino acid adenylation by NRPS" EXACT []
is_a: GO:0043041 ! amino acid activation for nonribosomal peptide biosynthetic process

[Term]
id: GO:0043043
name: peptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [GOC:dph, GOC:jl, http://cancerweb.ncl.ac.uk]
subset: gosubset_prok
synonym: "peptide anabolism" EXACT []
synonym: "peptide biosynthesis" EXACT []
synonym: "peptide formation" EXACT []
synonym: "peptide synthesis" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0043044
name: ATP-dependent chromatin remodeling
namespace: biological_process
def: "Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors." [GOC:jl, PMID:12042764]
synonym: "ATP-dependent chromatin remodelling" EXACT []
is_a: GO:0006338 ! chromatin remodeling

[Term]
id: GO:0043045
name: DNA methylation during embryonic development
namespace: biological_process
def: "The covalent transfer of a methyl group to C-5 of cytosine during embryogenesis, when DNA methylation patterns are established." [GOC:go_curators, PMID:12138111]
synonym: "de novo DNA methylation" NARROW []
is_a: GO:0006306 ! DNA methylation
relationship: part_of GO:0009790 ! embryonic development

[Term]
id: GO:0043046
name: DNA methylation during gametogenesis
namespace: biological_process
def: "The covalent transfer of a methyl group to C-5 of cytosine during gamete generation, when DNA methylation patterns are established." [GOC:go_curators, PMID:12138111]
synonym: "de novo DNA methylation" NARROW []
is_a: GO:0006306 ! DNA methylation
relationship: part_of GO:0007276 ! gamete generation

[Term]
id: GO:0043047
name: single-stranded telomeric DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382]
synonym: "telomeric ssDNA binding" EXACT [GOC:mah]
is_a: GO:0003697 ! single-stranded DNA binding
is_a: GO:0042162 ! telomeric DNA binding

[Term]
id: GO:0043048
name: dolichyl monophosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a phosphorylated dolichol derivative." [GOC:jl]
subset: gosubset_prok
synonym: "dolichyl monophosphate anabolism" EXACT []
synonym: "dolichyl monophosphate biosynthesis" EXACT []
synonym: "dolichyl monophosphate formation" EXACT []
synonym: "dolichyl monophosphate synthesis" EXACT []
is_a: GO:0019408 ! dolichol biosynthetic process

[Term]
id: GO:0043049
name: otic placode formation
namespace: biological_process
def: "The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain." [GOC:go_curators, PMID:12668634]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0030916 ! otic vesicle formation

[Term]
id: GO:0043050
name: pharyngeal pumping
namespace: biological_process
def: "The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes." [GOC:cab1, PMID:2181052]
synonym: "pumping behavior" RELATED []
is_a: GO:0042755 ! eating behavior

[Term]
id: GO:0043051
name: regulation of pharyngeal pumping
namespace: biological_process
def: "Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes." [GOC:cab1, PMID:2181052]
is_a: GO:0060259 ! regulation of feeding behavior
relationship: regulates GO:0043050 ! pharyngeal pumping

[Term]
id: GO:0043052
name: thermotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467]
synonym: "taxis in response to temperature stimulus" EXACT []
xref: Wikipedia:Thermotaxis
is_a: GO:0009266 ! response to temperature stimulus
is_a: GO:0042330 ! taxis

[Term]
id: GO:0043053
name: dauer entry
namespace: biological_process
def: "Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, PMID:10077613]
synonym: "nematode entry into dormancy" EXACT []
is_a: GO:0022611 ! dormancy process
relationship: part_of GO:0040024 ! dauer larval development

[Term]
id: GO:0043054
name: dauer exit
namespace: biological_process
def: "Exit from the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, PMID:12620986]
synonym: "exit from nematode dormancy" EXACT []
is_a: GO:0022611 ! dormancy process
relationship: part_of GO:0040024 ! dauer larval development

[Term]
id: GO:0043055
name: maintenance of dauer
namespace: biological_process
def: "Maintenance of a nematode during the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, WB_REF:wm2003ab740]
synonym: "maintenance of dormancy in the nematode" EXACT []
is_a: GO:0022611 ! dormancy process
relationship: part_of GO:0040024 ! dauer larval development

[Term]
id: GO:0043056
name: forward locomotion
namespace: biological_process
def: "Anterior movement of an organism, following the direction of the head of the animal." [GOC:go_curators]
is_a: GO:0033058 ! directional locomotion

[Term]
id: GO:0043057
name: backward locomotion
namespace: biological_process
def: "Posterior movement of an organism, e.g. following the direction of the tail of an animal." [GOC:go_curators]
is_a: GO:0033058 ! directional locomotion

[Term]
id: GO:0043058
name: regulation of backward locomotion
namespace: biological_process
def: "Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism." [GOC:go_curators]
is_a: GO:0040012 ! regulation of locomotion
relationship: regulates GO:0043057 ! backward locomotion

[Term]
id: GO:0043059
name: regulation of forward locomotion
namespace: biological_process
def: "Any process that modulates the speed, mechanical force, or rhythm of the anterior movement of an organism." [GOC:go_curators]
is_a: GO:0040012 ! regulation of locomotion
relationship: regulates GO:0043056 ! forward locomotion

[Term]
id: GO:0043060
name: meiotic metaphase I plate congression
namespace: biological_process
def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I." [GOC:cab1, PMID:10809666]
is_a: GO:0051311 ! meiotic metaphase plate congression
relationship: part_of GO:0045143 ! homologous chromosome segregation

[Term]
id: GO:0043061
name: meiotic metaphase II plate congression
namespace: biological_process
def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis II." [GOC:cab1, PMID:10809666]
is_a: GO:0051311 ! meiotic metaphase plate congression
relationship: part_of GO:0045144 ! meiotic sister chromatid segregation

[Term]
id: GO:0043062
name: extracellular structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_goa
subset: goslim_pir
subset: gosubset_prok
synonym: "extracellular structure organisation" EXACT [GOC:curators]
synonym: "extracellular structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0009987 ! cellular process
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0043063
name: intercellular bridge organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another." [GOC:jic]
synonym: "intercellular bridge organisation" EXACT [GOC:curators]
synonym: "intercellular bridge organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0043062 ! extracellular structure organization

[Term]
id: GO:0043064
name: flagellum organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a flagellum, a long thin projection from a cell, used in movement." [GOC:jl, http://cancerweb.ncl.ac.uk]
subset: gosubset_prok
synonym: "flagellum organisation" EXACT [GOC:curators]
synonym: "flagellum organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0043065
name: positive regulation of apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptosis." [GOC:jl]
synonym: "activation of apoptosis" NARROW []
synonym: "stimulation of apoptosis" NARROW []
synonym: "up regulation of apoptosis" EXACT []
synonym: "up-regulation of apoptosis" EXACT []
synonym: "upregulation of apoptosis" EXACT []
is_a: GO:0042981 ! regulation of apoptosis
is_a: GO:0043068 ! positive regulation of programmed cell death
relationship: positively_regulates GO:0006915 ! apoptosis

[Term]
id: GO:0043066
name: negative regulation of apoptosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis." [GOC:jl]
synonym: "down regulation of apoptosis" EXACT []
synonym: "down-regulation of apoptosis" EXACT []
synonym: "downregulation of apoptosis" EXACT []
synonym: "inhibition of apoptosis" NARROW []
is_a: GO:0042981 ! regulation of apoptosis
is_a: GO:0043069 ! negative regulation of programmed cell death
relationship: negatively_regulates GO:0006915 ! apoptosis

[Term]
id: GO:0043067
name: regulation of programmed cell death
namespace: biological_process
alt_id: GO:0043070
def: "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
synonym: "regulation of non-apoptotic programmed cell death" NARROW []
is_a: GO:0010941 ! regulation of cell death
relationship: regulates GO:0012501 ! programmed cell death

[Term]
id: GO:0043068
name: positive regulation of programmed cell death
namespace: biological_process
alt_id: GO:0043071
def: "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
synonym: "activation of programmed cell death" NARROW []
synonym: "positive regulation of non-apoptotic programmed cell death" NARROW []
synonym: "stimulation of programmed cell death" NARROW []
synonym: "up regulation of programmed cell death" EXACT []
synonym: "up-regulation of programmed cell death" EXACT []
synonym: "upregulation of programmed cell death" EXACT []
is_a: GO:0010942 ! positive regulation of cell death
is_a: GO:0043067 ! regulation of programmed cell death
relationship: positively_regulates GO:0012501 ! programmed cell death

[Term]
id: GO:0043069
name: negative regulation of programmed cell death
namespace: biological_process
alt_id: GO:0043072
def: "Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]
synonym: "down regulation of programmed cell death" EXACT []
synonym: "down-regulation of programmed cell death" EXACT []
synonym: "downregulation of programmed cell death" EXACT []
synonym: "inhibition of programmed cell death" NARROW []
synonym: "negative regulation of non-apoptotic programmed cell death" NARROW []
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0060548 ! negative regulation of cell death
relationship: negatively_regulates GO:0012501 ! programmed cell death

[Term]
id: GO:0043073
name: germ cell nucleus
namespace: cellular_component
def: "The nucleus of a germ cell, a reproductive cell in multicellular organisms." [GOC:go_curators, http://cancerweb.ncl.ac.uk]
synonym: "germ-cell nucleus" EXACT []
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0043075
name: sperm cell nucleus (sensu Magnoliophyta)
namespace: cellular_component
def: "OBSOLETE. The nucleus of a plant pollen cell, the male gamete, and its descendents." [GOC:jl]
comment: This term was made obsolete because the definition was incorrect.
synonym: "pollen germ cell nucleus" EXACT []
synonym: "pollen germ-cell nucleus" EXACT []
is_obsolete: true
consider: GO:0048555

[Term]
id: GO:0043076
name: megasporocyte nucleus
namespace: cellular_component
def: "The nucleus of a megasporocyte, a diploid cell that undergoes meiosis to produce four megaspores, and its descendents." [GOC:jl, ISBN:0618254153]
synonym: "megaspore mother cell nucleus" EXACT []
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0043077
name: initiation of acetate catabolic process
namespace: biological_process
def: "The activation of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:jl]
subset: gosubset_prok
synonym: "initiation of acetate breakdown" EXACT []
synonym: "initiation of acetate catabolism" EXACT []
synonym: "initiation of acetate degradation" EXACT []
is_a: GO:0045754 ! positive regulation of acetate catabolic process

[Term]
id: GO:0043078
name: polar nucleus
namespace: cellular_component
def: "Either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus." [ISBN:0618254153]
is_a: GO:0043076 ! megasporocyte nucleus

[Term]
id: GO:0043079
name: antipodal cell nucleus
namespace: cellular_component
def: "The nucleus of an antipodal cell, one of three cells of the embryo sac in angiosperms, found at the chalazal end of the embryo away from the point of entry of the pollen tube, and its descendents." [GOC:jl, http://cancerweb.ncl.ac.uk]
is_a: GO:0043076 ! megasporocyte nucleus

[Term]
id: GO:0043082
name: megagametophyte egg cell nucleus
namespace: cellular_component
def: "The nucleus of a plant egg cell. This nucleus is found at the micropylar end of the embryo." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0043076 ! megasporocyte nucleus

[Term]
id: GO:0043083
name: synaptic cleft
namespace: cellular_component
def: "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released." [GOC:jl, http://synapses.mcg.edu/anatomy/chemical/synapse.stm]
xref: NIF_Subcellular:sao243541954
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044456 ! synapse part

[Term]
id: GO:0043084
name: penile erection
namespace: biological_process
def: "The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:jl, Wikipedia:Penile_erection]
xref: Wikipedia:Erection#Penile_erection
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0007620 ! copulation

[Term]
id: GO:0043085
name: positive regulation of catalytic activity
namespace: biological_process
def: "Any process that activates or increases the activity of an enzyme." [GOC:jl, GOC:tb]
subset: gosubset_prok
synonym: "activation of enzyme activity" NARROW []
synonym: "positive regulation of enzyme activity" EXACT [GOC:tb]
synonym: "stimulation of enzyme activity" NARROW []
synonym: "up regulation of enzyme activity" EXACT []
synonym: "up-regulation of enzyme activity" EXACT []
synonym: "upregulation of enzyme activity" EXACT []
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0043086
name: negative regulation of catalytic activity
namespace: biological_process
def: "Any process that stops or reduces the activity of an enzyme." [GOC:jl, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of enzyme activity" EXACT []
synonym: "down-regulation of enzyme activity" EXACT []
synonym: "downregulation of enzyme activity" EXACT []
synonym: "inhibition of enzyme activity" NARROW []
synonym: "negative regulation of enzyme activity" EXACT [GOC:tb]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0043087
name: regulation of GTPase activity
namespace: biological_process
def: "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl]
subset: gosubset_prok
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0043088
name: regulation of Cdc42 GTPase activity
namespace: biological_process
def: "Any process that modulates the activity of the GTPase Cdc42." [GOC:jl]
is_a: GO:0032319 ! regulation of Rho GTPase activity
relationship: part_of GO:0032489 ! regulation of Cdc42 protein signal transduction

[Term]
id: GO:0043089
name: positive regulation of Cdc42 GTPase activity
namespace: biological_process
def: "Any process that activates or increases the activity of the GTPase Cdc42." [GOC:jl]
synonym: "stimulation of Cdc42 GTPase activity" NARROW []
synonym: "up regulation of Cdc42 GTPase activity" EXACT []
synonym: "up-regulation of Cdc42 GTPase activity" EXACT []
synonym: "upregulation of Cdc42 GTPase activity" EXACT []
is_a: GO:0032321 ! positive regulation of Rho GTPase activity
is_a: GO:0043088 ! regulation of Cdc42 GTPase activity

[Term]
id: GO:0043090
name: amino acid import
namespace: biological_process
def: "The directed movement of amino acids into a cell or organelle." [GOC:jl]
subset: gosubset_prok
synonym: "amino acid uptake" EXACT []
is_a: GO:0006865 ! amino acid transport

[Term]
id: GO:0043091
name: L-arginine import
namespace: biological_process
def: "The directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle." [GOC:jl, GOC:jsg, GOC:mah]
synonym: "L-arginine uptake" EXACT []
is_a: GO:0015809 ! arginine transport
is_a: GO:0043092 ! L-amino acid import

[Term]
id: GO:0043092
name: L-amino acid import
namespace: biological_process
def: "The directed movement of L-enantiomer amino acids into a cell or organelle." [GOC:jl, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-amino acid uptake" EXACT []
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0043090 ! amino acid import

[Term]
id: GO:0043093
name: binary fission
namespace: biological_process
def: "A process in which two similarly sized and shaped cells are formed by the division of one cell, the process by which most bacteria reproduce." [ISBN:0815108893]
subset: gosubset_prok
xref: Wikipedia:Binary_fission
is_a: GO:0019954 ! asexual reproduction
is_a: GO:0032505 ! reproduction of a single-celled organism

[Term]
id: GO:0043094
name: cellular metabolic compound salvage
namespace: biological_process
def: "Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells." [GOC:mlg]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0043095
name: regulation of GTP cyclohydrolase I activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme GTP cyclohydrolase I." [GOC:jl]
subset: gosubset_prok
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0043096
name: purine base salvage
namespace: biological_process
def: "Any process that generates purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from derivatives of them without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0009113 ! purine base biosynthetic process
is_a: GO:0043101 ! purine salvage

[Term]
id: GO:0043097
name: pyrimidine nucleoside salvage
namespace: biological_process
def: "Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0008655 ! pyrimidine salvage
is_a: GO:0043174 ! nucleoside salvage
is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process

[Term]
id: GO:0043098
name: purine deoxyribonucleoside salvage
namespace: biological_process
def: "Any process which produces a purine deoxyribonucleoside from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043101 ! purine salvage
is_a: GO:0043174 ! nucleoside salvage
is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0043099
name: pyrimidine deoxyribonucleoside salvage
namespace: biological_process
def: "Any process that generates a pyrimidine deoxyribonucleoside from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043097 ! pyrimidine nucleoside salvage
is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0043100
name: pyrimidine base salvage
namespace: biological_process
def: "Any process that generates pyrimidine bases, 1,3-diazine organic nitrogenous bases, from derivatives of them without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0008655 ! pyrimidine salvage

[Term]
id: GO:0043101
name: purine salvage
namespace: biological_process
def: "Any process that generates a purine, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0034404 ! nucleobase, nucleoside and nucleotide biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0043102
name: amino acid salvage
namespace: biological_process
def: "Any process which produces an amino acid from derivatives of it, without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0043103
name: hypoxanthine salvage
namespace: biological_process
def: "Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "adenine, hypoxanthine and their nucleoside salvage" NARROW []
synonym: "guanine, xanthine and their nucleoside salvage" NARROW []
is_a: GO:0043096 ! purine base salvage
is_a: GO:0046101 ! hypoxanthine biosynthetic process

[Term]
id: GO:0043104
name: positive regulation of GTP cyclohydrolase I activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme GTP cyclohydrolase I." [GOC:jl]
subset: gosubset_prok
synonym: "activation of GTP cyclohydrolase I activity" NARROW []
synonym: "stimulation of GTP cyclohydrolase I activity" NARROW []
synonym: "up regulation of GTP cyclohydrolase I activity" EXACT []
synonym: "up-regulation of GTP cyclohydrolase I activity" EXACT []
synonym: "upregulation of GTP cyclohydrolase I activity" EXACT []
is_a: GO:0043095 ! regulation of GTP cyclohydrolase I activity
is_a: GO:0051345 ! positive regulation of hydrolase activity

[Term]
id: GO:0043105
name: negative regulation of GTP cyclohydrolase I activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme GTP cyclohydrolase I." [GOC:jl]
subset: gosubset_prok
synonym: "down regulation of GTP cyclohydrolase I activity" EXACT []
synonym: "down-regulation of GTP cyclohydrolase I activity" EXACT []
synonym: "downregulation of GTP cyclohydrolase I activity" EXACT []
synonym: "inhibition of GTP cyclohydrolase I activity" NARROW []
is_a: GO:0043095 ! regulation of GTP cyclohydrolase I activity
is_a: GO:0051346 ! negative regulation of hydrolase activity

[Term]
id: GO:0043106
name: GTP cyclohydrolase I binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme GTP cyclohydrolase I." [GOC:jl]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0043107
name: type IV pilus-dependent motility
namespace: biological_process
def: "Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility." [GOC:go_curators, PMID:12704238]
subset: gosubset_prok
synonym: "social gliding motility" NARROW []
synonym: "TFP-dependent motility" EXACT []
synonym: "TFP-dependent movement" EXACT []
synonym: "twitching motility" NARROW []
synonym: "type 4 pilus-dependent motility" EXACT []
synonym: "type four pilus-dependent motility" EXACT []
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0043108
name: pilus retraction
namespace: biological_process
def: "The process of withdrawing a pilus back into a cell." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0043711 ! pilus organization

[Term]
id: GO:0043110
name: rDNA spacer replication fork barrier binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription." [GOC:jl, GOC:mah, PMID:14645529]
synonym: "RFB binding" EXACT []
synonym: "RTS1 barrier binding" EXACT []
synonym: "RTS1 element binding" EXACT []
is_a: GO:0000182 ! rDNA binding
is_a: GO:0031634 ! replication fork barrier binding

[Term]
id: GO:0043111
name: replication fork arrest
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork." [GOC:jl, PMID:14645529]
comment: See also the biological process term 'site-specific replication termination ; GO:0071170' and its children.
subset: gosubset_prok
synonym: "negative regulation of DNA replication at replication fork barrier" EXACT [GOC:dph, GOC:tb]
synonym: "replication fork blocking" EXACT []
synonym: "replication fork stalling" EXACT []
is_a: GO:0008156 ! negative regulation of DNA replication
is_a: GO:0045005 ! maintenance of fidelity during DNA-dependent DNA replication

[Term]
id: GO:0043112
name: receptor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:jl]
subset: gosubset_prok
synonym: "receptor metabolism" EXACT []
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0043113
name: receptor clustering
namespace: biological_process
def: "Grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response." [GOC:bf]
is_a: GO:0043112 ! receptor metabolic process
relationship: part_of GO:0007172 ! signal complex assembly

[Term]
id: GO:0043114
name: regulation of vascular permeability
namespace: biological_process
def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid." [GOC:jl]
is_a: GO:0003018 ! vascular process in circulatory system
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0008015 ! blood circulation

[Term]
id: GO:0043115
name: precorrin-2 dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: precorrin-2 (dihydrosirohydrochlorin) + NAD+ = sirohydrochlorin + NADH + H+." [EC:1.3.1.76]
subset: gosubset_prok
synonym: "1,3-dimethyluroporphyrinogen III dehydrogenase activity" EXACT []
synonym: "CysG" RELATED [EC:1.3.1.76]
synonym: "dihydrosirohydrochlorin dehydrogenase activity" EXACT []
synonym: "Met8p" RELATED [EC:1.3.1.76]
synonym: "precorrin-2 oxidase activity" EXACT [EC:1.3.1.76]
synonym: "precorrin-2:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.76]
synonym: "SirC" RELATED [EC:1.3.1.76]
synonym: "siroheme synthase activity" BROAD []
xref: EC:1.3.1.76
xref: MetaCyc:DIMETHUROPORDEHYDROG-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043116
name: negative regulation of vascular permeability
namespace: biological_process
def: "Any process that reduces the extent to which blood vessels can be pervaded by fluid." [GOC:jl]
synonym: "down regulation of vascular permeability" EXACT []
synonym: "down-regulation of vascular permeability" EXACT []
synonym: "downregulation of vascular permeability" EXACT []
synonym: "inhibition of vascular permeability" NARROW []
is_a: GO:0043114 ! regulation of vascular permeability

[Term]
id: GO:0043117
name: positive regulation of vascular permeability
namespace: biological_process
def: "Any process that increases the extent to which blood vessels can be pervaded by fluid." [GOC:jl]
synonym: "activation of vascular permeability" NARROW []
synonym: "stimulation of vascular permeability" NARROW []
synonym: "up regulation of vascular permeability" EXACT []
synonym: "up-regulation of vascular permeability" EXACT []
synonym: "upregulation of vascular permeability" EXACT []
is_a: GO:0043114 ! regulation of vascular permeability

[Term]
id: GO:0043120
name: tumor necrosis factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages." [GOC:jl, http://lookwayup.com/]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0043121
name: neurotrophin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth." [GOC:jl, http://www.mercksource.com/]
synonym: "neurotrophin TRK receptor activity" RELATED []
is_a: GO:0019838 ! growth factor binding

[Term]
id: GO:0043122
name: regulation of I-kappaB kinase/NF-kappaB cascade
namespace: biological_process
def: "Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade." [GOC:jl, PMID:12773372]
is_a: GO:0010627 ! regulation of protein kinase cascade
relationship: regulates GO:0007249 ! I-kappaB kinase/NF-kappaB cascade

[Term]
id: GO:0043123
name: positive regulation of I-kappaB kinase/NF-kappaB cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade." [GOC:jl]
synonym: "activation of I-kappaB kinase/NF-kappaB cascade" NARROW []
synonym: "stimulation of I-kappaB kinase/NF-kappaB cascade" NARROW []
synonym: "up regulation of I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "up-regulation of I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "upregulation of I-kappaB kinase/NF-kappaB cascade" EXACT []
is_a: GO:0010740 ! positive regulation of protein kinase cascade
is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB cascade
relationship: positively_regulates GO:0007249 ! I-kappaB kinase/NF-kappaB cascade

[Term]
id: GO:0043124
name: negative regulation of I-kappaB kinase/NF-kappaB cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade." [GOC:jl]
synonym: "down regulation of I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "down-regulation of I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "downregulation of I-kappaB kinase/NF-kappaB cascade" EXACT []
synonym: "inhibition of I-kappaB kinase/NF-kappaB cascade" NARROW []
is_a: GO:0010741 ! negative regulation of protein kinase cascade
is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB cascade
relationship: negatively_regulates GO:0007249 ! I-kappaB kinase/NF-kappaB cascade

[Term]
id: GO:0043125
name: ErbB-3 class receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-3/HER3." [GOC:jl]
synonym: "HER3 receptor binding" EXACT []
synonym: "Neu/ErbB-2 receptor activity" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0043126
name: regulation of 1-phosphatidylinositol 4-kinase activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme 1-phosphatidylinositol 4-kinase." [GOC:jl]
subset: gosubset_prok
synonym: "regulation of PI4K activity" EXACT []
is_a: GO:0043550 ! regulation of lipid kinase activity

[Term]
id: GO:0043127
name: negative regulation of 1-phosphatidylinositol 4-kinase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme 1-phosphatidylinositol 4-kinase." [GOC:jl]
subset: gosubset_prok
synonym: "down regulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
synonym: "down-regulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
synonym: "downregulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
synonym: "inhibition of 1-phosphatidylinositol 4-kinase activity" NARROW []
synonym: "negative regulation of PI4K activity" EXACT []
is_a: GO:0043126 ! regulation of 1-phosphatidylinositol 4-kinase activity
is_a: GO:0090219 ! negative regulation of lipid kinase activity

[Term]
id: GO:0043128
name: positive regulation of 1-phosphatidylinositol 4-kinase activity
namespace: biological_process
def: "Any process that activates or increases the activity of 1-phosphatidylinositol 4-kinase." [GOC:jl]
subset: gosubset_prok
synonym: "activation of 1-phosphatidylinositol 4-kinase activity" NARROW []
synonym: "positive regulation of PI4K activity" EXACT []
synonym: "stimulation of 1-phosphatidylinositol 4-kinase activity" NARROW []
synonym: "up regulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
synonym: "up-regulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
synonym: "upregulation of 1-phosphatidylinositol 4-kinase activity" EXACT []
is_a: GO:0043126 ! regulation of 1-phosphatidylinositol 4-kinase activity
is_a: GO:0090218 ! positive regulation of lipid kinase activity

[Term]
id: GO:0043129
name: surfactant homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an equilibrium of the surface-active lipoprotein mixture which coats the alveoli." [PMID:9751757]
is_a: GO:0048875 ! chemical homeostasis within a tissue

[Term]
id: GO:0043130
name: ubiquitin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]
xref: Reactome:160991 "ubiquitin binding"
is_a: GO:0032182 ! small conjugating protein binding

[Term]
id: GO:0043131
name: enucleation
namespace: biological_process
def: "The process by which nucleated precursor cells lose their nucleus during erythrocyte maturation." [GOC:hgd]
is_a: GO:0022411 ! cellular component disassembly
relationship: part_of GO:0043354 ! enucleate erythrocyte maturation

[Term]
id: GO:0043132
name: NAD transport
namespace: biological_process
def: "The directed movement of nicotinamide adenine dinucleotide into, out of, within or between cells by means of some external agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl]
synonym: "NAD (oxidized) transport" EXACT []
synonym: "NAD (reduced) transport" EXACT []
synonym: "NADH transport" EXACT []
synonym: "nicotinamide adenine dinucleotide transport" EXACT []
synonym: "oxidized NAD transport" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide transport" EXACT []
synonym: "reduced NAD transport" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide transport" EXACT []
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0043133
name: hindgut contraction
namespace: biological_process
def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk]
is_a: GO:0006939 ! smooth muscle contraction
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0043134
name: regulation of hindgut contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, http://cancerweb.ncl.ac.uk]
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0044058 ! regulation of digestive system process
relationship: regulates GO:0043133 ! hindgut contraction

[Term]
id: GO:0043135
name: 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of the diphosphate bond in 5-phosphoribosyl 1-pyrophosphate." [GOC:jl, http://cancerweb.ncl.ac.uk, PMID:12370170]
synonym: "PRPP pyrophosphatase activity" EXACT []
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0043136
name: glycerol-3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate." [GOC:jl]
xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0043137
name: DNA replication, removal of RNA primer
namespace: biological_process
def: "Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease." [GOC:jl, PMID:12424238]
subset: gosubset_prok
synonym: "Okazaki initiator RNA removal" EXACT []
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0006401 ! RNA catabolic process
relationship: part_of GO:0033567 ! DNA replication, Okazaki fragment processing

[Term]
id: GO:0043138
name: 3'-5' DNA helicase activity
namespace: molecular_function
def: "Catalysis of the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl]
synonym: "3' to 5' DNA helicase activity" EXACT []
is_a: GO:0003678 ! DNA helicase activity

[Term]
id: GO:0043139
name: 5'-3' DNA helicase activity
namespace: molecular_function
def: "Catalysis of the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl]
synonym: "5' to 3' DNA helicase activity" EXACT []
is_a: GO:0003678 ! DNA helicase activity

[Term]
id: GO:0043140
name: ATP-dependent 3'-5' DNA helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ATP-dependent 3' to 5' DNA helicase activity" EXACT []
is_a: GO:0004003 ! ATP-dependent DNA helicase activity
is_a: GO:0043138 ! 3'-5' DNA helicase activity

[Term]
id: GO:0043141
name: ATP-dependent 5'-3' DNA helicase activity
namespace: molecular_function
alt_id: GO:0008722
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ATP-dependent 5' to 3' DNA helicase activity" EXACT []
synonym: "DNA helicase IV activity" NARROW []
xref: EC:3.6.1.-
is_a: GO:0004003 ! ATP-dependent DNA helicase activity
is_a: GO:0043139 ! 5'-3' DNA helicase activity

[Term]
id: GO:0043142
name: single-stranded DNA-dependent ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single-stranded DNA; drives another reaction." [GOC:go_curators]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ssDNA-dependent ATPase activity" EXACT []
is_a: GO:0008094 ! DNA-dependent ATPase activity

[Term]
id: GO:0043143
name: translational machinery localization
namespace: biological_process
def: "Any process by which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." [GOC:jl]
subset: gosubset_prok
synonym: "establishment and maintenance of translational machinery localization" EXACT []
synonym: "establishment and maintenance of translational protein localization" EXACT []
synonym: "translational protein localization" EXACT []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0043144
name: snoRNA processing
namespace: biological_process
def: "Any process involved in the conversion of a primary small nucleolar RNA (snoRNA) transcript into a mature snoRNA." [GOC:go_curators, PMID:12773397]
is_a: GO:0016074 ! snoRNA metabolic process
is_a: GO:0034470 ! ncRNA processing

[Term]
id: GO:0043145
name: snoRNA 3'-end cleavage
namespace: biological_process
def: "The endonucleolytic cleavage of snoRNA 3' ends, which is required for mature snoRNAs to be functional." [GOC:go_curators, PMID:12773397]
synonym: "snoRNA 3' end cleavage" EXACT []
is_a: GO:0031126 ! snoRNA 3'-end processing

[Term]
id: GO:0043146
name: spindle stabilization
namespace: biological_process
def: "Any process involved in maintaining the structure and integrity of the spindle." [GOC:go_curators]
is_a: GO:0007026 ! negative regulation of microtubule depolymerization
relationship: part_of GO:0007051 ! spindle organization

[Term]
id: GO:0043147
name: meiotic spindle stabilization
namespace: biological_process
def: "The cell cycle process whereby spindle integrity is maintained during M phase of meiosis." [GOC:go_curators]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0043146 ! spindle stabilization
relationship: part_of GO:0000212 ! meiotic spindle organization

[Term]
id: GO:0043148
name: mitotic spindle stabilization
namespace: biological_process
def: "The cell cycle process whereby spindle integrity is maintained during M phase of mitosis." [GOC:go_curators]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0043146 ! spindle stabilization
is_a: GO:0060236 ! regulation of mitotic spindle organization

[Term]
id: GO:0043149
name: stress fiber assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity." [GOC:go_curators, GOC:mah, PMID:16651381]
synonym: "actin cable assembly" RELATED [GOC:mah]
synonym: "actin cable formation" RELATED [GOC:mah]
synonym: "stress fibre biosynthesis" RELATED []
synonym: "stress fibre formation" RELATED []
is_a: GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0043150
name: DNA synthesis during double-strand break repair via homologous recombination
namespace: biological_process
def: "The synthesis of DNA during the process of double-strand break repair via homologous recombination." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0000731 ! DNA synthesis during DNA repair
relationship: part_of GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:0043151
name: DNA synthesis during double-strand break repair via single-strand annealing
namespace: biological_process
def: "The synthesis of DNA during the process of double-strand break repair via single-strand annealing." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0000731 ! DNA synthesis during DNA repair
relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing

[Term]
id: GO:0043152
name: induction of bacterial agglutination
namespace: biological_process
def: "Any process by which infecting bacteria are clumped together by a host organism." [GOC:jl]
is_a: GO:0019731 ! antibacterial humoral response

[Term]
id: GO:0043153
name: entrainment of circadian clock by photoperiod
namespace: biological_process
def: "The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl]
is_a: GO:0009648 ! photoperiodism
is_a: GO:0009649 ! entrainment of circadian clock

[Term]
id: GO:0043154
name: negative regulation of caspase activity
namespace: biological_process
alt_id: GO:0001719
def: "Any process that stops, prevents or reduces the frequency, rate or extent of caspase activity." [GOC:jl]
synonym: "down regulation of caspase activity" EXACT []
synonym: "down-regulation of caspase activity" EXACT []
synonym: "downregulation of caspase activity" EXACT []
synonym: "inhibition of caspase activation" NARROW []
synonym: "inhibition of caspase activity" NARROW []
synonym: "negative regulation of caspase activation" EXACT []
is_a: GO:0010466 ! negative regulation of peptidase activity
is_a: GO:0043281 ! regulation of caspase activity

[Term]
id: GO:0043155
name: negative regulation of photosynthesis, light reaction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the light-dependent reaction of photosynthesis." [GOC:jl]
synonym: "down regulation of photosynthesis, light reaction" EXACT []
synonym: "down-regulation of photosynthesis, light reaction" EXACT []
synonym: "downregulation of photosynthesis, light reaction" EXACT []
synonym: "inhibition of photosynthesis, light reaction" NARROW []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0042548 ! regulation of photosynthesis, light reaction
relationship: negatively_regulates GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0043156
name: chromatin remodeling in response to cation stress
namespace: biological_process
def: "Structural changes to eukaryotic chromatin occurring as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:jl, GOC:vw, PMID:14762213]
is_a: GO:0006338 ! chromatin remodeling
is_a: GO:0071473 ! cellular response to cation stress

[Term]
id: GO:0043157
name: response to cation stress
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:jl, PMID:14762213]
subset: gosubset_prok
is_a: GO:0009651 ! response to salt stress

[Term]
id: GO:0043158
name: heterocyst differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a heterocyst, a differentiated cell in certain cyanobacteria whose purpose is to fix nitrogen." [GOC:jl]
subset: gosubset_prok
synonym: "heterocyst biosynthesis" EXACT []
synonym: "heterocyst cell differentiation" EXACT []
synonym: "heterocyst formation" EXACT []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0043159
name: acrosomal matrix
namespace: cellular_component
def: "A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction." [GOC:jl, PMID:8949900, PMID:9139729]
is_a: GO:0044433 ! cytoplasmic vesicle part
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0001669 ! acrosomal vesicle

[Term]
id: GO:0043160
name: acrosomal lumen
namespace: cellular_component
def: "The volume enclosed within the acrosome membrane." [GOC:go_curators]
is_a: GO:0043202 ! lysosomal lumen
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0001669 ! acrosomal vesicle

[Term]
id: GO:0043161
name: proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]
synonym: "proteasomal pathway" EXACT []
synonym: "proteasomal processing" RELATED []
synonym: "proteasomal ubiquitin-dependent protein breakdown" EXACT []
synonym: "proteasomal ubiquitin-dependent protein catabolism" EXACT []
synonym: "proteasomal ubiquitin-dependent protein degradation" EXACT []
synonym: "proteasome pathway" RELATED []
xref: Reactome:174255 "Degradation multiubiquitinated Cyclin A"
xref: Reactome:436195 "Degradation multiubiquitinated Cyclin A"
xref: Reactome:458598 "Degradation multiubiquitinated Cyclin A"
xref: Reactome:497580 "Degradation multiubiquitinated Cyclin A"
xref: Reactome:512726 "Degradation multiubiquitinated Cyclin A"
xref: Reactome:545293 "Degradation multiubiquitinated Cyclin A"
xref: Reactome:550104 "Degradation multiubiquitinated Cyclin A"
xref: Reactome:555293 "Degradation multiubiquitinated Cyclin A"
xref: Reactome:564103 "Degradation multiubiquitinated Cyclin A"
xref: Reactome:576319 "Degradation multiubiquitinated Cyclin A"
xref: Reactome:589392 "Degradation multiubiquitinated Cyclin A"
is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process
is_a: GO:0010498 ! proteasomal protein catabolic process

[Term]
id: GO:0043162
name: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]
synonym: "ubiquitin-dependent protein breakdown via the multivesicular body pathway" EXACT []
synonym: "ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT []
synonym: "ubiquitin-dependent protein catabolism via the MVB pathway" EXACT []
synonym: "ubiquitin-dependent protein degradation via the multivesicular body pathway" EXACT []
is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process

[Term]
id: GO:0043163
name: cell envelope organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "cell envelope organisation" EXACT [GOC:curators]
synonym: "cell envelope organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0043164
name: Gram-negative-bacterium-type cell wall biogenesis
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the type of cell wall found in Gram-negative-bacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane." [GOC:jl, GOC:mtg_sensu, ISBN:0815108893]
subset: gosubset_prok
synonym: "1-2nm peptidoglycan-based cell wall biogenesis" EXACT []
synonym: "cell wall anabolism" BROAD []
synonym: "cell wall assembly" BROAD []
synonym: "cell wall biosynthetic process" BROAD []
synonym: "cell wall formation" BROAD []
synonym: "cell wall synthesis" BROAD []
is_a: GO:0009273 ! peptidoglycan-based cell wall biogenesis
relationship: part_of GO:0043163 ! cell envelope organization

[Term]
id: GO:0043165
name: Gram-negative-bacterium-type cell outer membrane assembly
namespace: biological_process
def: "The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:jl, ISBN:0135712254]
subset: gosubset_prok
synonym: "cell outer membrane biogenesis" RELATED [GOC:mah]
is_a: GO:0016044 ! cellular membrane organization
relationship: part_of GO:0043163 ! cell envelope organization

[Term]
id: GO:0043167
name: ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ions, charged atoms or groups of atoms." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "atom binding" RELATED []
is_a: GO:0005488 ! binding

[Term]
id: GO:0043168
name: anion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with anions, charged atoms or groups of atoms with a net negative charge." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043167 ! ion binding

[Term]
id: GO:0043169
name: cation binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043167 ! ion binding

[Term]
id: GO:0043170
name: macromolecule metabolic process
namespace: biological_process
alt_id: GO:0043283
def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [ChEBI:33694, GOC:mah]
subset: goslim_goa
subset: goslim_pir
subset: gosubset_prok
synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "macromolecule metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0043171
name: peptide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jl]
subset: gosubset_prok
synonym: "peptide breakdown" EXACT []
synonym: "peptide catabolism" EXACT []
synonym: "peptide degradation" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0043172
name: ferredoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ferredoxin anabolism" EXACT []
synonym: "ferredoxin biosynthesis" EXACT []
synonym: "ferredoxin formation" EXACT []
synonym: "ferredoxin synthesis" EXACT []
is_a: GO:0006124 ! ferredoxin metabolic process
is_a: GO:0034645 ! cellular macromolecule biosynthetic process

[Term]
id: GO:0043173
name: nucleotide salvage
namespace: biological_process
def: "Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
xref: Wikipedia:Nucleotide_salvage
is_a: GO:0009165 ! nucleotide biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0043174
name: nucleoside salvage
namespace: biological_process
def: "Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0009163 ! nucleoside biosynthetic process
is_a: GO:0043094 ! cellular metabolic compound salvage

[Term]
id: GO:0043175
name: RNA polymerase core enzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the prokaryotic RNA polymerase core enzyme, the part of the RNA polymerase consisting of two alpha, one beta and one beta prime subunits." [GOC:jl, ISBN:0321000382]
subset: gosubset_prok
is_a: GO:0070063 ! RNA polymerase binding

[Term]
id: GO:0043176
name: amine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0043177
name: organic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0043178
name: alcohol binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0043179
name: rhythmic excitation
namespace: biological_process
def: "Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit." [GOC:go_curators, ISBN:0195088433]
is_a: GO:0060024 ! rhythmic synaptic transmission

[Term]
id: GO:0043180
name: rhythmic inhibition
namespace: biological_process
def: "Any process involved in the generation of rhythmic, synchronous inhibitory synaptic inputs in a neural circuit." [GOC:go_curators]
is_a: GO:0060024 ! rhythmic synaptic transmission

[Term]
id: GO:0043181
name: vacuolar sequestering
namespace: biological_process
def: "The process of transporting a substance into, and confining within, a vacuole." [GOC:jl]
synonym: "retention in vacuole" EXACT []
synonym: "sequestering in vacuole" EXACT []
synonym: "sequestration in vacuole" EXACT []
synonym: "storage in vacuole" EXACT []
synonym: "vacuolar retention" EXACT []
synonym: "vacuolar sequestration" EXACT []
synonym: "vacuolar storage" EXACT []
is_a: GO:0051651 ! maintenance of location in cell

[Term]
id: GO:0043182
name: vacuolar sequestering of sodium ion
namespace: biological_process
def: "The process of transporting sodium ions into, and confining within, a vacuole." [GOC:jl]
synonym: "sequestering of sodium ion (Na+) in vacuole" EXACT []
synonym: "sequestration of sodium ion (Na+) in vacuole" EXACT []
synonym: "sodium ion (Na+) retention in vacuole" EXACT []
synonym: "sodium ion (Na+) storage in vacuole" EXACT []
synonym: "vacuolar sequestering of sodium ion (Na+)" EXACT []
synonym: "vacuolar sequestration of sodium ion (Na+)" EXACT []
synonym: "vacuolar sodium ion (Na+) retention" EXACT []
synonym: "vacuolar sodium ion (Na+) storage" EXACT []
is_a: GO:0043181 ! vacuolar sequestering
relationship: part_of GO:0006883 ! cellular sodium ion homeostasis

[Term]
id: GO:0043183
name: vascular endothelial growth factor receptor 1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with vascular endothelial growth factor receptor 1." [GOC:st]
synonym: "Flt-1 binding" EXACT []
synonym: "VEGF receptor 1 binding" EXACT []
synonym: "VEGFR 1 binding" EXACT []
is_a: GO:0005172 ! vascular endothelial growth factor receptor binding

[Term]
id: GO:0043184
name: vascular endothelial growth factor receptor 2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2." [GOC:st]
synonym: "Flk-1 binding" EXACT []
synonym: "KDR binding" BROAD []
synonym: "kinase domain region binding" EXACT []
synonym: "VEGF receptor 2 binding" EXACT []
synonym: "VEGFR 2 binding" EXACT []
is_a: GO:0005172 ! vascular endothelial growth factor receptor binding

[Term]
id: GO:0043185
name: vascular endothelial growth factor receptor 3 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with vascular endothelial growth factor receptor 3." [GOC:st]
synonym: "fms-like-tyrosine kinase (Flt)-4 binding" EXACT []
synonym: "VEGF receptor 3 binding" EXACT []
synonym: "VEGFR 3 binding" EXACT []
is_a: GO:0005172 ! vascular endothelial growth factor receptor binding

[Term]
id: GO:0043186
name: P granule
namespace: cellular_component
alt_id: GO:0018994
def: "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]
synonym: "germline granule" EXACT []
synonym: "nuage" BROAD []
synonym: "polar granule" EXACT []
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0060293 ! germ plasm

[Term]
id: GO:0043187
name: cell septum surface
namespace: cellular_component
def: "The extracellular (rather than the intracellular) exterior of a dividing septum; this surface is usually composed of cell wall material, for example, lineal (1,3)-beta-D-glucan in S. pombe." [GOC:go_curators]
synonym: "septum surface" BROAD []
is_a: GO:0044457 ! cell septum part

[Term]
id: GO:0043188
name: cell septum edging
namespace: cellular_component
def: "The cell wall material that surrounds the septum in fungal cells." [GOC:vw]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0043189
name: H4/H2A histone acetyltransferase complex
namespace: cellular_component
def: "A multisubunit complex that catalyzes the acetylation of histones H4 and H2A." [GOC:mah]
synonym: "H4/H2A HAT complex" EXACT []
is_a: GO:0000123 ! histone acetyltransferase complex

[Term]
id: GO:0043190
name: ATP-binding cassette (ABC) transporter complex
namespace: cellular_component
alt_id: GO:0043191
alt_id: GO:0043192
def: "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107]
subset: goslim_pir
subset: gosubset_prok
synonym: "ABC-type efflux permease activity" NARROW []
synonym: "ABC-type efflux porter activity" NARROW []
synonym: "ABC-type uptake permease activity" NARROW []
synonym: "ATP-binding cassette (ABC) transporter activity" RELATED []
synonym: "mating pheromone exporter" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0043193
name: positive regulation of gene-specific transcription
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the DNA-dependent transcription of a specific gene or genes." [GOC:jl]
subset: gosubset_prok
synonym: "activation of gene-specific transcription" NARROW []
synonym: "stimulation of gene-specific transcription" NARROW []
synonym: "up regulation of gene-specific transcription" EXACT []
synonym: "up-regulation of gene-specific transcription" EXACT []
synonym: "upregulation of gene-specific transcription" EXACT []
is_a: GO:0032583 ! regulation of gene-specific transcription
is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent

[Term]
id: GO:0043194
name: initial segment
namespace: cellular_component
def: "Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment." [GOC:nln]
xref: NIF_Subcellular:sao256000789
is_a: GO:0033267 ! axon part
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0043195
name: terminal button
namespace: cellular_component
def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:nln]
synonym: "bouton" EXACT []
synonym: "presynaptic bouton" EXACT []
synonym: "synaptic bouton" EXACT []
synonym: "terminal bouton" EXACT []
is_a: GO:0033267 ! axon part
relationship: part_of GO:0043679 ! axon terminus

[Term]
id: GO:0043196
name: varicosity
namespace: cellular_component
def: "Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:nln]
is_a: GO:0033267 ! axon part
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0043197
name: dendritic spine
namespace: cellular_component
def: "Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln]
synonym: "dendrite spine" EXACT []
xref: NIF_Subcellular:sao1799103720
xref: Wikipedia:Dendritic_spine
is_a: GO:0044309 ! neuron spine
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:0043198
name: dendritic shaft
namespace: cellular_component
def: "Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines." [GOC:nln]
xref: NIF_Subcellular:sao2034472720
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:0043199
name: sulfate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with sulfate (SO42-), a negatively charged small molecule." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0043200
name: response to amino acid stimulus
namespace: biological_process
alt_id: GO:0010237
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [ChEBI:33709, GOC:ef, GOC:mlg]
synonym: "response to amino acid" EXACT []
is_a: GO:0001101 ! response to acid
is_a: GO:0014075 ! response to amine stimulus

[Term]
id: GO:0043201
name: response to leucine
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus." [GOC:mlg]
is_a: GO:0043200 ! response to amino acid stimulus

[Term]
id: GO:0043202
name: lysosomal lumen
namespace: cellular_component
def: "The volume enclosed within the lysosomal membrane." [GOC:jl, PMID:15213228]
is_a: GO:0005775 ! vacuolar lumen
relationship: part_of GO:0005764 ! lysosome

[Term]
id: GO:0043203
name: axon hillock
namespace: cellular_component
def: "Portion of the neuronal cell soma from which the axon originates." [GOC:nln]
xref: NIF_Subcellular:sao627227260
xref: Wikipedia:Axon_hillock
is_a: GO:0033267 ! axon part
relationship: part_of GO:0043025 ! neuronal cell body

[Term]
id: GO:0043204
name: perikaryon
namespace: cellular_component
def: "The portion of the cell soma (cell body) that excludes the nucleus." [GOC:jl]
synonym: "cell soma cytoplasm" RELATED []
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043025 ! neuronal cell body

[Term]
id: GO:0043205
name: fibril
namespace: cellular_component
def: "Extracellular matrix material consisting of polysaccharides and protein." [PMID:12704238]
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0005578 ! proteinaceous extracellular matrix

[Term]
id: GO:0043206
name: fibril organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of fibrils, extracellular matrix material consisting of polysaccharides and protein." [GOC:mlg]
synonym: "fibril organisation" EXACT [GOC:curators]
synonym: "fibril organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030198 ! extracellular matrix organization

[Term]
id: GO:0043207
name: response to external biotic stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0009607 ! response to biotic stimulus

[Term]
id: GO:0043208
name: glycosphingolipid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:jl]
is_a: GO:0046625 ! sphingolipid binding
is_a: GO:0051861 ! glycolipid binding

[Term]
id: GO:0043209
name: myelin sheath
namespace: cellular_component
def: "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." [GOC:jl, NIF_Subcellular:sao-593830697, Wikipedia:Myelin]
synonym: "Schwann Cell Myelin Sheath" EXACT []
xref: NIF_Subcellular:sao-593830697
xref: Wikipedia:Myelin
is_a: GO:0044464 ! cell part

[Term]
id: GO:0043210
name: alkanesulfonate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon moiety." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0043168 ! anion binding

[Term]
id: GO:0043211
name: carbohydrate-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of carbohydrates across a membrane." [GOC:mlg]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "carbohydrate ABC transporter" NARROW []
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0043212
name: carbohydrate-exporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) = ADP + phosphate + carbohydrate(out)." [GOC:mlg]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
is_a: GO:0043211 ! carbohydrate-transporting ATPase activity

[Term]
id: GO:0043213
name: bacteriocin transport
namespace: biological_process
def: "The directed movement of a bacteriocin into, out of, within or between cells by means of some external agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0015031 ! protein transport

[Term]
id: GO:0043214
name: bacteriocin-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of bacteriocins across a membrane." [GOC:mlg]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "bacteriocin ABC transporter" NARROW []
is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity

[Term]
id: GO:0043215
name: daunorubicin transport
namespace: biological_process
def: "The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl, GOC:mlg, http://www.mercksource.com/]
is_a: GO:0015893 ! drug transport

[Term]
id: GO:0043216
name: daunorubicin-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + daunorubicin(in) = ADP + phosphate + daunorubicin(out)." [GOC:mlg]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "daunorubicin ABC transporter" NARROW []
is_a: GO:0015238 ! drug transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0043217
name: myelin maintenance
namespace: biological_process
def: "The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath." [GOC:dgh]
is_a: GO:0007009 ! plasma membrane organization
relationship: part_of GO:0042552 ! myelination

[Term]
id: GO:0043218
name: compact myelin
namespace: cellular_component
def: "The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs." [GOC:dgh, NIF_Subcellular:sao-1123256993]
synonym: "Schwann Cell Compact Myelin" EXACT []
xref: NIF_Subcellular:sao-1123256993
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043209 ! myelin sheath

[Term]
id: GO:0043219
name: lateral loop
namespace: cellular_component
def: "Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode." [GOC:dgh]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0043209 ! myelin sheath

[Term]
id: GO:0043220
name: Schmidt-Lanterman cleft
namespace: cellular_component
alt_id: GO:0044287
def: "Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman clefts occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier." [GOC:dgh]
synonym: "Schmidtt-Lanterman cleft" EXACT []
xref: NIF_Subcellular:sao254777664
is_a: GO:0033267 ! axon part
relationship: part_of GO:0043218 ! compact myelin

[Term]
id: GO:0043221
name: SMC protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization." [GOC:jl, PMID:9640531]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043222
name: SMC/kleisin ring complex
namespace: cellular_component
def: "A molecular ring complex composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1 and Smc3, and the kleisin protein Scc1." [GOC:jl, PMID:12667442]
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000793 ! condensed chromosome

[Term]
id: GO:0043223
name: cytoplasmic SCF ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
synonym: "cytoplasmic cullin complex" EXACT []
synonym: "cytoplasmic SCF complex" EXACT []
synonym: "cytoplasmic Skp1/Cul1/F-box protein complex" EXACT []
is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0043224
name: nuclear SCF ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
synonym: "nuclear cullin complex" EXACT []
synonym: "nuclear SCF complex" EXACT []
synonym: "nuclear Skp1/Cul1/F-box protein complex" EXACT []
is_a: GO:0000152 ! nuclear ubiquitin ligase complex
is_a: GO:0019005 ! SCF ubiquitin ligase complex

[Term]
id: GO:0043225
name: anion transmembrane-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + anion(out) = ADP + phosphate + anion(in)." [GOC:mlg]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "anion ABC transporter" NARROW []
synonym: "anion-transporting ATPase activity" EXACT []
is_a: GO:0008509 ! anion transmembrane transporter activity
is_a: GO:0042625 ! ATPase activity, coupled to transmembrane movement of ions

[Term]
id: GO:0043226
name: organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
xref: NIF_Subcellular:sao1539965131
xref: Wikipedia:Organelle
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0043227
name: membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
subset: gosubset_prok
synonym: "membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao414196390
is_a: GO:0043226 ! organelle

[Term]
id: GO:0043228
name: non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: gosubset_prok
synonym: "non-membrane-enclosed organelle" EXACT []
xref: NIF_Subcellular:sao1456184038
is_a: GO:0043226 ! organelle

[Term]
id: GO:0043229
name: intracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043226 ! organelle
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0043230
name: extracellular organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043226 ! organelle
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0043231
name: intracellular membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "intracellular membrane-enclosed organelle" EXACT []
is_a: GO:0043227 ! membrane-bounded organelle
is_a: GO:0043229 ! intracellular organelle

[Term]
id: GO:0043232
name: intracellular non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "intracellular non-membrane-enclosed organelle" EXACT []
is_a: GO:0043228 ! non-membrane-bounded organelle
is_a: GO:0043229 ! intracellular organelle

[Term]
id: GO:0043233
name: organelle lumen
namespace: cellular_component
def: "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]
is_a: GO:0031974 ! membrane-enclosed lumen
is_a: GO:0044422 ! organelle part

[Term]
id: GO:0043234
name: protein complex
namespace: cellular_component
def: "Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules." [GOC:go_curators]
comment: Note that although at some level almost all cellular components can be thought of as protein complexes, this term is intended to exclude structures composed of the same repeating subunit or subunits, for example microtubules. Protein complexes encompassed by this term are generally not structural, and usually have a defined set of subunits.
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
synonym: "protein-protein complex" EXACT []
xref: Wikipedia:Protein_complex
is_a: GO:0032991 ! macromolecular complex

[Term]
id: GO:0043235
name: receptor complex
namespace: cellular_component
def: "Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0043236
name: laminin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells." [GOC:ecd]
is_a: GO:0005515 ! protein binding
is_a: GO:0050840 ! extracellular matrix binding

[Term]
id: GO:0043237
name: laminin-1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1." [GOC:go_curators]
is_a: GO:0043236 ! laminin binding

[Term]
id: GO:0043238
name: laminin-2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with laminin-2, a glycoprotein trimer with the subunit composition alpha2, beta1, gamma 1." [GOC:go_curators]
is_a: GO:0043236 ! laminin binding

[Term]
id: GO:0043239
name: laminin-4 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with laminin-4, a glycoprotein trimer with the subunit composition alpha2, beta2, gamma 1." [GOC:go_curators]
is_a: GO:0043236 ! laminin binding

[Term]
id: GO:0043240
name: Fanconi anaemia nuclear complex
namespace: cellular_component
def: "A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]
synonym: "FA complex" EXACT []
synonym: "FA core complex" EXACT []
synonym: "FA nuclear complex" EXACT []
synonym: "Fanconi anaemia complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0043241
name: protein complex disassembly
namespace: biological_process
def: "The disaggregation of a protein complex into its constituent components. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups." [GOC:jl]
subset: gosubset_prok
is_a: GO:0032984 ! macromolecular complex disassembly

[Term]
id: GO:0043242
name: negative regulation of protein complex disassembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]
synonym: "down regulation of protein complex disassembly" EXACT []
synonym: "down-regulation of protein complex disassembly" EXACT []
synonym: "downregulation of protein complex disassembly" EXACT []
synonym: "inhibition of protein complex disassembly" NARROW []
is_a: GO:0043244 ! regulation of protein complex disassembly
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0043241 ! protein complex disassembly

[Term]
id: GO:0043243
name: positive regulation of protein complex disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]
synonym: "activation of protein complex disassembly" NARROW []
synonym: "stimulation of protein complex disassembly" NARROW []
synonym: "up regulation of protein complex disassembly" EXACT []
synonym: "up-regulation of protein complex disassembly" EXACT []
synonym: "upregulation of protein complex disassembly" EXACT []
is_a: GO:0043244 ! regulation of protein complex disassembly
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0043241 ! protein complex disassembly

[Term]
id: GO:0043244
name: regulation of protein complex disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]
subset: gosubset_prok
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0043241 ! protein complex disassembly

[Term]
id: GO:0043245
name: extraorganismal space
namespace: cellular_component
def: "The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0043246
name: megasome
namespace: cellular_component
def: "Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex." [http://cancerweb.ncl.ac.uk/, PMID:11206117, PMID:1999020]
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0043247
name: telomere maintenance in response to DNA damage
namespace: biological_process
def: "Any process that occur in response to the presence of critically short telomeres." [PMID:15279784]
is_a: GO:0000723 ! telomere maintenance
is_a: GO:0006974 ! response to DNA damage stimulus

[Term]
id: GO:0043248
name: proteasome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]
subset: gosubset_prok
synonym: "26S proteasome assembly" NARROW []
synonym: "proteasome complex assembly" EXACT []
synonym: "proteasome maturation" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0043249
name: erythrocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state." [GOC:devbiol, GOC:jl]
synonym: "RBC maturation" EXACT [CL:0000232]
synonym: "red blood cell maturation" EXACT [CL:0000232]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0048821 ! erythrocyte development

[Term]
id: GO:0043250
name: sodium-dependent organic anion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner." [GOC:go_curators]
is_a: GO:0008514 ! organic anion transmembrane transporter activity

[Term]
id: GO:0043251
name: sodium-dependent organic anion transport
namespace: biological_process
def: "The directed, sodium-dependent, movement of organic anions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators]
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0043252
name: sodium-independent organic anion transport
namespace: biological_process
def: "The directed, sodium-independent, movement of organic anions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators]
is_a: GO:0015711 ! organic anion transport

[Term]
id: GO:0043253
name: chloroplast ribosome
namespace: cellular_component
def: "A ribosome contained within a chloroplast." [GOC:ecd]
is_a: GO:0009547 ! plastid ribosome
is_a: GO:0044434 ! chloroplast part
relationship: part_of GO:0009570 ! chloroplast stroma

[Term]
id: GO:0043254
name: regulation of protein complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0006461 ! protein complex assembly

[Term]
id: GO:0043255
name: regulation of carbohydrate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl]
subset: gosubset_prok
synonym: "regulation of carbohydrate anabolism" EXACT []
synonym: "regulation of carbohydrate biosynthesis" EXACT []
synonym: "regulation of carbohydrate formation" EXACT []
synonym: "regulation of carbohydrate synthesis" EXACT []
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009889 ! regulation of biosynthetic process
relationship: regulates GO:0016051 ! carbohydrate biosynthetic process

[Term]
id: GO:0043256
name: laminin complex
namespace: cellular_component
def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes." [GOC:jl, http://www.sdbonline.org/fly/newgene/laminna1.htm, PMID:10842354]
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0005605 ! basal lamina

[Term]
id: GO:0043257
name: laminin-8 complex
namespace: cellular_component
def: "A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043258
name: laminin-9 complex
namespace: cellular_component
def: "A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043259
name: laminin-10 complex
namespace: cellular_component
def: "A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043260
name: laminin-11 complex
namespace: cellular_component
def: "A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043261
name: laminin-12 complex
namespace: cellular_component
def: "A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains." [GOC:jl, PMID:10842354]
is_a: GO:0043256 ! laminin complex

[Term]
id: GO:0043262
name: adenosine-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + H2O = AMP + phosphate." [EC:3.6.1.5, PMID:1470606]
synonym: "adenosine diphosphatase activity" EXACT []
synonym: "adenosinepyrophosphatase activity" EXACT [EC:3.6.1.6]
synonym: "ADPase" BROAD [EC:3.6.1.3]
synonym: "ADPase activity" EXACT [EC:3.6.1.6]
synonym: "ATP diphosphohydrolase" BROAD [EC:3.6.1.3]
synonym: "ATP diphosphohydrolase (phosphate-forming) activity" EXACT [EC:3.6.1.3]
synonym: "ATP-diphosphatase activity" EXACT [EC:3.6.1.3]
synonym: "ATP-diphosphohydrolase activity" EXACT [EC:3.6.1.3]
xref: MetaCyc:APYRASE-RXN
is_a: GO:0017110 ! nucleoside-diphosphatase activity

[Term]
id: GO:0043263
name: cellulosome
namespace: cellular_component
def: "An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose." [GOC:jl, PMID:11601609]
subset: gosubset_prok
xref: Wikipedia:Cellulosome
is_a: GO:0043264 ! extracellular non-membrane-bounded organelle

[Term]
id: GO:0043264
name: extracellular non-membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:jl]
subset: gosubset_prok
synonym: "extracellular non-membrane-enclosed organelle" EXACT []
is_a: GO:0043228 ! non-membrane-bounded organelle
is_a: GO:0043230 ! extracellular organelle

[Term]
id: GO:0043265
name: ectoplasm
namespace: cellular_component
def: "Granule free cytoplasm, lying immediately below the plasma membrane." [http://cancerweb.ncl.ac.uk/]
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0043266
name: regulation of potassium ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl]
synonym: "regulation of K+ conductance" NARROW []
synonym: "regulation of K+ transport" EXACT []
synonym: "regulation of potassium conductance" NARROW []
synonym: "regulation of potassium ion conductance" NARROW []
synonym: "regulation of potassium transport" EXACT []
is_a: GO:0010959 ! regulation of metal ion transport
relationship: regulates GO:0006813 ! potassium ion transport

[Term]
id: GO:0043267
name: negative regulation of potassium ion transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl]
synonym: "down regulation of potassium ion transport" EXACT []
synonym: "down-regulation of potassium ion transport" EXACT []
synonym: "downregulation of potassium ion transport" EXACT []
synonym: "inhibition of potassium ion transport" NARROW []
synonym: "negative regulation of K+ transport" EXACT []
synonym: "negative regulation of potassium ion conductance" NARROW []
synonym: "negative regulation of potassium transport" EXACT []
synonym: "regulation of K+ conductance" NARROW []
synonym: "regulation of potassium conductance" NARROW []
synonym: "transmembrane conductance regulator activity" RELATED []
is_a: GO:0043266 ! regulation of potassium ion transport
is_a: GO:0043271 ! negative regulation of ion transport
relationship: negatively_regulates GO:0006813 ! potassium ion transport

[Term]
id: GO:0043268
name: positive regulation of potassium ion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl]
synonym: "activation of potassium ion transport" NARROW []
synonym: "positive regulation of K+ conductance" NARROW []
synonym: "positive regulation of K+ transport" EXACT []
synonym: "positive regulation of potassium conductance" NARROW []
synonym: "positive regulation of potassium ion conductance" NARROW []
synonym: "positive regulation of potassium transport" EXACT []
synonym: "stimulation of potassium ion transport" NARROW []
synonym: "up regulation of potassium ion transport" EXACT []
synonym: "up-regulation of potassium ion transport" EXACT []
synonym: "upregulation of potassium ion transport" EXACT []
is_a: GO:0043266 ! regulation of potassium ion transport
is_a: GO:0043270 ! positive regulation of ion transport
relationship: positively_regulates GO:0006813 ! potassium ion transport

[Term]
id: GO:0043269
name: regulation of ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0006811 ! ion transport

[Term]
id: GO:0043270
name: positive regulation of ion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl]
synonym: "activation of ion transport" NARROW []
synonym: "stimulation of ion transport" NARROW []
synonym: "up regulation of ion transport" EXACT []
synonym: "up-regulation of ion transport" EXACT []
synonym: "upregulation of ion transport" EXACT []
is_a: GO:0043269 ! regulation of ion transport
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0006811 ! ion transport

[Term]
id: GO:0043271
name: negative regulation of ion transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl]
synonym: "down regulation of ion transport" EXACT []
synonym: "down-regulation of ion transport" EXACT []
synonym: "downregulation of ion transport" EXACT []
synonym: "inhibition of ion transport" NARROW []
is_a: GO:0043269 ! regulation of ion transport
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0006811 ! ion transport

[Term]
id: GO:0043272
name: ethylene biosynthetic process during jasmonic acid and ethylene-dependent systemic resistance
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), occurring during the process of jasmonic acid and ethylene-dependent systemic resistance." [GOC:jl]
synonym: "ethylene anabolism during jasmonic acid and ethylene-dependent systemic resistance" EXACT []
synonym: "ethylene formation during jasmonic acid and ethylene-dependent systemic resistance" EXACT []
synonym: "ethylene synthesis during jasmonic acid and ethylene-dependent systemic resistance" EXACT []
is_a: GO:0009693 ! ethylene biosynthetic process
relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance

[Term]
id: GO:0043273
name: CTPase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction." [GOC:go_curators]
synonym: "cytidine triphosphatase activity" EXACT []
is_a: GO:0017111 ! nucleoside-triphosphatase activity

[Term]
id: GO:0043274
name: phospholipase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid." [GOC:jl]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0043275
name: glutamate carboxypeptidase II activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu." [BRENDA:3.4.17.21, GOC:jl]
comment: This term was made obsolete because it represents a gene product.
synonym: "acetylaspartylglutamate dipeptidase activity" EXACT []
synonym: "folate hydrolase activity" RELATED [EC:3.4.17.21]
synonym: "folylpolyglutamate hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "membrane glutamate carboxypeptidase" NARROW [EC:3.4.17.21]
synonym: "mGCP" RELATED [EC:3.4.17.21]
synonym: "microsomal gamma-glutamyl carboxypeptidase" NARROW [EC:3.4.17.21]
synonym: "N-acetylated alpha-linked acidic dipeptidase activity" EXACT [EC:3.4.17.21]
synonym: "N-acetylated-alpha-linked-amino dipeptidase activity" EXACT [EC:3.4.17.21]
synonym: "N-acetylated-gamma-linked-acidic dipeptidase (NAALADase)" EXACT [EC:3.4.17.21]
synonym: "N-acetylated-gamma-linked-acidic dipeptidase activity" EXACT [EC:3.4.17.21]
synonym: "NAALA dipeptidase activity" EXACT [EC:3.4.17.21]
synonym: "NAALADase activity" EXACT [EC:3.4.17.21]
synonym: "prostate-specific membrane antigen" RELATED [EC:3.4.17.21]
synonym: "prostrate-specific membrane antigen" RELATED [EC:3.4.17.21]
synonym: "PSM antigen" RELATED [EC:3.4.17.21]
synonym: "PSMA" RELATED [EC:3.4.17.21]
synonym: "pteroylpoly-gamma-glutamate carboxypeptidase activity" EXACT [EC:3.4.17.21]
synonym: "pteroylpoly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "pteroylpolygammaglutamyl hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "pteroylpolyglutamate hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "pteroylpolyglutamic acid hydrolase activity" EXACT [EC:3.4.17.21]
synonym: "rat NAAG peptidase" NARROW [EC:3.4.17.21]
xref: EC:3.4.17.21
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0043276
name: anoikis
namespace: biological_process
def: "Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix." [GOC:jl, http://www.copewithcytokines.de/]
synonym: "detachment induced cell death" EXACT []
synonym: "suspension induced apoptosis" EXACT []
xref: Wikipedia:Anoikis
is_a: GO:0006915 ! apoptosis

[Term]
id: GO:0043277
name: apoptotic cell clearance
namespace: biological_process
def: "The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte." [GOC:rk, PMID:14685684]
comment: Note that unlike mammals or Drosophila, C. elegans (and many lower organisms) do not have professional macrophages/phagocytes, instead cell corpses are engulfed by neighboring cells. Cell types that can function as engulfing cells include hypodermal cells, gonadal sheath cells, pharyngeal muscle cells, and intestinal cells.
synonym: "apoptotic cell removal" EXACT []
synonym: "efferocytosis" EXACT [PMID:17548650]
synonym: "programmed cell clearance" EXACT []
is_a: GO:0006909 ! phagocytosis

[Term]
id: GO:0043278
name: response to morphine
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [ChEBI:17303, GOC:ef, GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0014072 ! response to isoquinoline alkaloid

[Term]
id: GO:0043279
name: response to alkaloid
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0043280
name: positive regulation of caspase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:jl]
synonym: "activation of caspase activity" NARROW []
synonym: "stimulation of caspase activity" NARROW []
synonym: "up regulation of caspase activity" EXACT []
synonym: "up-regulation of caspase activity" EXACT []
synonym: "upregulation of caspase activity" EXACT []
is_a: GO:0010952 ! positive regulation of peptidase activity
is_a: GO:0043281 ! regulation of caspase activity

[Term]
id: GO:0043281
name: regulation of caspase activity
namespace: biological_process
alt_id: GO:0043026
def: "Any process that modulates the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:jl]
synonym: "regulation of caspase activation" NARROW []
is_a: GO:0042981 ! regulation of apoptosis
is_a: GO:0052548 ! regulation of endopeptidase activity

[Term]
id: GO:0043282
name: pharyngeal muscle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx." [GOC:go_curators]
is_a: GO:0007517 ! muscle organ development
relationship: part_of GO:0060465 ! pharynx development

[Term]
id: GO:0043286
name: regulation of poly(3-hydroxyalkanoate) biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl]
subset: gosubset_prok
synonym: "regulation of PHA" EXACT []
synonym: "regulation of poly(3-hydroxyalkanoate) anabolism" EXACT []
synonym: "regulation of poly(3-hydroxyalkanoate) biosynthesis" EXACT []
synonym: "regulation of poly(3-hydroxyalkanoate) formation" EXACT []
synonym: "regulation of poly(3-hydroxyalkanoate) synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
relationship: regulates GO:0042621 ! poly(3-hydroxyalkanoate) biosynthetic process

[Term]
id: GO:0043287
name: poly(3-hydroxyalkanoate) binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with poly(3-hydroxyalkanoate)s, polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl]
subset: gosubset_prok
synonym: "PHA binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0043288
name: apocarotenoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm]
subset: gosubset_prok
synonym: "apocarotenoid metabolism" EXACT []
is_a: GO:0006721 ! terpenoid metabolic process

[Term]
id: GO:0043289
name: apocarotenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of apocarotenoids by the oxidative cleavage of carotenoids. Many apocarotenoids are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm]
subset: gosubset_prok
synonym: "apocarotenoid anabolism" EXACT []
synonym: "apocarotenoid biosynthesis" EXACT []
synonym: "apocarotenoid formation" EXACT []
synonym: "apocarotenoid synthesis" EXACT []
is_a: GO:0043288 ! apocarotenoid metabolic process

[Term]
id: GO:0043290
name: apocarotenoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm]
subset: gosubset_prok
synonym: "apocarotenoid breakdown" EXACT []
synonym: "apocarotenoid catabolism" EXACT []
synonym: "apocarotenoid degradation" EXACT []
is_a: GO:0043288 ! apocarotenoid metabolic process

[Term]
id: GO:0043291
name: RAVE complex
namespace: cellular_component
def: "A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme." [PMID:11283612, PMID:11844802]
synonym: "regulator of the (H+)-ATPase of the vacuolar and endosomal membranes" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0043292
name: contractile fiber
namespace: cellular_component
def: "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194]
synonym: "contractile fibre" EXACT []
synonym: "muscle fiber" BROAD []
synonym: "muscle fibre" BROAD []
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0043293
name: apoptosome
namespace: cellular_component
def: "A multisubunit protein complex involved in the activation of apoptosis. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms." [PMID:10428850, PMID:11406413, PMID:12176339, PMID:15189137]
xref: Wikipedia:Apoptosome
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0043294
name: mitochondrial glutamate synthase complex (NADH)
namespace: cellular_component
def: "A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525]
is_a: GO:0031027 ! glutamate synthase complex (NADH)
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0005759 ! mitochondrial matrix

[Term]
id: GO:0043295
name: glutathione binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0042277 ! peptide binding

[Term]
id: GO:0043296
name: apical junction complex
namespace: cellular_component
def: "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in invertebrates is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, PMID:12525486, PMID:15196556]
synonym: "apical cell junction complex" EXACT [GOC:mah]
is_a: GO:0005911 ! cell-cell junction
relationship: part_of GO:0016327 ! apicolateral plasma membrane

[Term]
id: GO:0043297
name: apical junction assembly
namespace: biological_process
def: "The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556]
synonym: "apical junction complex assembly" EXACT [GOC:mah]
is_a: GO:0007043 ! cell-cell junction assembly

[Term]
id: GO:0043299
name: leukocyte degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"]
comment: This term was improved by GO_REF:0000022. It was moved.
synonym: "immune cell degranulation" EXACT []
synonym: "immune cell granule exocytosis" EXACT []
synonym: "leucocyte degranulation" EXACT []
synonym: "leukocyte granule exocytosis" EXACT []
is_a: GO:0002252 ! immune effector process
is_a: GO:0045055 ! regulated secretory pathway

[Term]
id: GO:0043300
name: regulation of leukocyte degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "regulation of immune cell degranulation" EXACT []
synonym: "regulation of immune cell granule exocytosis" EXACT []
synonym: "regulation of leucocyte degranulation" EXACT []
synonym: "regulation of leukocyte granule exocytosis" EXACT []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0017157 ! regulation of exocytosis
relationship: regulates GO:0043299 ! leukocyte degranulation

[Term]
id: GO:0043301
name: negative regulation of leukocyte degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of leukocyte degranulation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of leukocyte degranulation" EXACT []
synonym: "down-regulation of leukocyte degranulation" EXACT []
synonym: "downregulation of leukocyte degranulation" EXACT []
synonym: "inhibition of leukocyte degranulation" NARROW []
synonym: "negative regulation of immune cell degranulation" EXACT []
synonym: "negative regulation of leucocyte degranulation" EXACT []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:0045920 ! negative regulation of exocytosis
relationship: negatively_regulates GO:0043299 ! leukocyte degranulation

[Term]
id: GO:0043302
name: positive regulation of leukocyte degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of leukocyte degranulation" NARROW []
synonym: "positive regulation of immune cell degranulation" EXACT []
synonym: "positive regulation of leucocyte degranulation" EXACT []
synonym: "stimulation of leukocyte degranulation" NARROW []
synonym: "up regulation of leukocyte degranulation" EXACT []
synonym: "up-regulation of leukocyte degranulation" EXACT []
synonym: "upregulation of leukocyte degranulation" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:0045921 ! positive regulation of exocytosis
relationship: positively_regulates GO:0043299 ! leukocyte degranulation

[Term]
id: GO:0043303
name: mast cell degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "mast cell granule exocytosis" EXACT []
is_a: GO:0002279 ! mast cell activation during immune response
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0002448 ! mast cell mediated immunity

[Term]
id: GO:0043304
name: regulation of mast cell degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of mast cell degranulation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "regulation of mast cell granule exocytosis" EXACT []
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0033006 ! regulation of mast cell activation during immune response
is_a: GO:0043300 ! regulation of leukocyte degranulation
relationship: regulates GO:0043303 ! mast cell degranulation

[Term]
id: GO:0043305
name: negative regulation of mast cell degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of mast cell degranulation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of mast cell degranulation" EXACT []
synonym: "down-regulation of mast cell degranulation" EXACT []
synonym: "downregulation of mast cell degranulation" EXACT []
synonym: "inhibition of mast cell degranulation" NARROW []
synonym: "negative regulation of mast cell granule exocytosis" EXACT []
is_a: GO:0033007 ! negative regulation of mast cell activation during immune response
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043304 ! regulation of mast cell degranulation
relationship: negatively_regulates GO:0043303 ! mast cell degranulation

[Term]
id: GO:0043306
name: positive regulation of mast cell degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mast cell degranulation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of mast cell degranulation" NARROW []
synonym: "positive regulation of mast cell granule exocytosis" EXACT []
synonym: "stimulation of mast cell degranulation" NARROW []
synonym: "up regulation of mast cell degranulation" EXACT []
synonym: "up-regulation of mast cell degranulation" EXACT []
synonym: "upregulation of mast cell degranulation" EXACT []
is_a: GO:0033008 ! positive regulation of mast cell activation during immune response
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043304 ! regulation of mast cell degranulation
relationship: positively_regulates GO:0043303 ! mast cell degranulation

[Term]
id: GO:0043307
name: eosinophil activation
namespace: biological_process
def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0043308
name: eosinophil degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "eosinophil granule exocytosis" EXACT []
is_a: GO:0002278 ! eosinophil activation during immune response
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0002447 ! eosinophil mediated immunity

[Term]
id: GO:0043309
name: regulation of eosinophil degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of eosinophil degranulation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "regulation of eosinophil granule exocytosis" EXACT []
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0043300 ! regulation of leukocyte degranulation
relationship: regulates GO:0043308 ! eosinophil degranulation

[Term]
id: GO:0043310
name: negative regulation of eosinophil degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of eosinophil degranulation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of eosinophil degranulation" EXACT []
synonym: "down-regulation of eosinophil degranulation" EXACT []
synonym: "downregulation of eosinophil degranulation" EXACT []
synonym: "inhibition of eosinophil degranulation" NARROW []
synonym: "negative regulation of eosinophil granule exocytosis" EXACT []
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043309 ! regulation of eosinophil degranulation
relationship: negatively_regulates GO:0043308 ! eosinophil degranulation

[Term]
id: GO:0043311
name: positive regulation of eosinophil degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eosinophil degranulation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of eosinophil degranulation" NARROW []
synonym: "positive regulation of eosinophil granule exocytosis" EXACT []
synonym: "stimulation of eosinophil degranulation" NARROW []
synonym: "up regulation of eosinophil degranulation" EXACT []
synonym: "up-regulation of eosinophil degranulation" EXACT []
synonym: "upregulation of eosinophil degranulation" EXACT []
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043309 ! regulation of eosinophil degranulation
relationship: positively_regulates GO:0043308 ! eosinophil degranulation

[Term]
id: GO:0043312
name: neutrophil degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "heterophil degranulation" RELATED []
synonym: "neutrophil granule exocytosis" EXACT []
is_a: GO:0002283 ! neutrophil activation during immune response
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0002446 ! neutrophil mediated immunity

[Term]
id: GO:0043313
name: regulation of neutrophil degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of neutrophil degranulation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "regulation of neutrophil granule exocytosis" EXACT []
is_a: GO:0002694 ! regulation of leukocyte activation
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
is_a: GO:0043300 ! regulation of leukocyte degranulation
relationship: regulates GO:0043312 ! neutrophil degranulation

[Term]
id: GO:0043314
name: negative regulation of neutrophil degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of neutrophil degranulation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of neutrophil degranulation" EXACT []
synonym: "down-regulation of neutrophil degranulation" EXACT []
synonym: "downregulation of neutrophil degranulation" EXACT []
synonym: "inhibition of neutrophil degranulation" NARROW []
synonym: "negative regulation of neutrophil granule exocytosis" EXACT []
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043313 ! regulation of neutrophil degranulation
relationship: negatively_regulates GO:0043312 ! neutrophil degranulation

[Term]
id: GO:0043315
name: positive regulation of neutrophil degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neutrophil degranulation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of neutrophil degranulation" NARROW []
synonym: "positive regulation of neutrophil granule exocytosis" EXACT []
synonym: "stimulation of neutrophil degranulation" NARROW []
synonym: "up regulation of neutrophil degranulation" EXACT []
synonym: "up-regulation of neutrophil degranulation" EXACT []
synonym: "upregulation of neutrophil degranulation" EXACT []
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043313 ! regulation of neutrophil degranulation
relationship: positively_regulates GO:0043312 ! neutrophil degranulation

[Term]
id: GO:0043316
name: cytotoxic T cell degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "cytotoxic T cell granule exocytosis" EXACT []
synonym: "cytotoxic T lymphocyte degranulation" EXACT []
synonym: "cytotoxic T lymphocyte granule exocytosis" EXACT []
synonym: "cytotoxic T-cell degranulation" EXACT []
synonym: "cytotoxic T-cell granule exocytosis" EXACT []
synonym: "cytotoxic T-lymphocyte degranulation" EXACT []
synonym: "cytotoxic T-lymphocyte granule exocytosis" EXACT []
is_a: GO:0002286 ! T cell activation during immune response
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0001913 ! T cell mediated cytotoxicity

[Term]
id: GO:0043317
name: regulation of cytotoxic T cell degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "regulation of cytotoxic T cell granule exocytosis" EXACT []
synonym: "regulation of cytotoxic T lymphocyte degranulation" EXACT []
synonym: "regulation of cytotoxic T lymphocyte granule exocytosis" EXACT []
synonym: "regulation of cytotoxic T-cell degranulation" EXACT []
synonym: "regulation of cytotoxic T-cell granule exocytosis" EXACT []
synonym: "regulation of cytotoxic T-lymphocyte degranulation" EXACT []
synonym: "regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT []
is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity
is_a: GO:0043300 ! regulation of leukocyte degranulation
is_a: GO:0050863 ! regulation of T cell activation
relationship: regulates GO:0043316 ! cytotoxic T cell degranulation

[Term]
id: GO:0043318
name: negative regulation of cytotoxic T cell degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of cytotoxic T cell degranulation" EXACT []
synonym: "down-regulation of cytotoxic T cell degranulation" EXACT []
synonym: "downregulation of cytotoxic T cell degranulation" EXACT []
synonym: "inhibition of cytotoxic T cell degranulation" NARROW []
synonym: "negative regulation of cytotoxic T cell granule exocytosis" EXACT []
synonym: "negative regulation of cytotoxic T lymphocyte degranulation" EXACT []
synonym: "negative regulation of cytotoxic T lymphocyte granule exocytosis" EXACT []
synonym: "negative regulation of cytotoxic T-cell degranulation" EXACT []
synonym: "negative regulation of cytotoxic T-cell granule exocytosis" EXACT []
synonym: "negative regulation of cytotoxic T-lymphocyte degranulation" EXACT []
synonym: "negative regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT []
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation
is_a: GO:0050868 ! negative regulation of T cell activation
relationship: negatively_regulates GO:0043316 ! cytotoxic T cell degranulation

[Term]
id: GO:0043319
name: positive regulation of cytotoxic T cell degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of cytotoxic T cell degranulation" NARROW []
synonym: "positive regulation of cytotoxic T cell granule exocytosis" EXACT []
synonym: "positive regulation of cytotoxic T lymphocyte degranulation" EXACT []
synonym: "positive regulation of cytotoxic T lymphocyte granule exocytosis" EXACT []
synonym: "positive regulation of cytotoxic T-cell degranulation" EXACT []
synonym: "positive regulation of cytotoxic T-cell granule exocytosis" EXACT []
synonym: "positive regulation of cytotoxic T-lymphocyte degranulation" EXACT []
synonym: "positive regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT []
synonym: "stimulation of cytotoxic T cell degranulation" NARROW []
synonym: "up regulation of cytotoxic T cell degranulation" EXACT []
synonym: "up-regulation of cytotoxic T cell degranulation" EXACT []
synonym: "upregulation of cytotoxic T cell degranulation" EXACT []
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation
is_a: GO:0050870 ! positive regulation of T cell activation
relationship: positively_regulates GO:0043316 ! cytotoxic T cell degranulation

[Term]
id: GO:0043320
name: natural killer cell degranulation
namespace: biological_process
def: "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "natural killer cell granule exocytosis" EXACT []
synonym: "NK cell degranulation" EXACT []
synonym: "NK cell granule exocytosis" EXACT []
is_a: GO:0002323 ! natural killer cell activation during immune response
is_a: GO:0043299 ! leukocyte degranulation
relationship: part_of GO:0042267 ! natural killer cell mediated cytotoxicity

[Term]
id: GO:0043321
name: regulation of natural killer cell degranulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of natural killer cell degranulation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "regulation of natural killer cell granule exocytosis" EXACT []
synonym: "regulation of NK cell degranulation" EXACT []
synonym: "regulation of NK cell granule exocytosis" EXACT []
is_a: GO:0032814 ! regulation of natural killer cell activation
is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity
is_a: GO:0043300 ! regulation of leukocyte degranulation
relationship: regulates GO:0043320 ! natural killer cell degranulation

[Term]
id: GO:0043322
name: negative regulation of natural killer cell degranulation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of natural killer cell degranulation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of natural killer cell degranulation" EXACT []
synonym: "down-regulation of natural killer cell degranulation" EXACT []
synonym: "downregulation of natural killer cell degranulation" EXACT []
synonym: "inhibition of natural killer cell degranulation" NARROW []
synonym: "negative regulation of natural killer cell granule exocytosis" EXACT []
synonym: "negative regulation of NK cell degranulation" EXACT []
synonym: "negative regulation of NK cell granule exocytosis" EXACT []
is_a: GO:0032815 ! negative regulation of natural killer cell activation
is_a: GO:0043301 ! negative regulation of leukocyte degranulation
is_a: GO:0043321 ! regulation of natural killer cell degranulation
relationship: negatively_regulates GO:0043320 ! natural killer cell degranulation

[Term]
id: GO:0043323
name: positive regulation of natural killer cell degranulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of natural killer cell degranulation" NARROW []
synonym: "positive regulation of natural killer cell granule exocytosis" EXACT []
synonym: "positive regulation of NK cell degranulation" EXACT []
synonym: "positive regulation of NK cell granule exocytosis" EXACT []
synonym: "stimulation of natural killer cell degranulation" NARROW []
synonym: "up regulation of natural killer cell degranulation" EXACT []
synonym: "up-regulation of natural killer cell degranulation" EXACT []
synonym: "upregulation of natural killer cell degranulation" EXACT []
is_a: GO:0032816 ! positive regulation of natural killer cell activation
is_a: GO:0043302 ! positive regulation of leukocyte degranulation
is_a: GO:0043321 ! regulation of natural killer cell degranulation
relationship: positively_regulates GO:0043320 ! natural killer cell degranulation

[Term]
id: GO:0043324
name: pigment metabolic process during developmental pigmentation
namespace: biological_process
def: "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin, occurring during the deposition of coloring matter in an organ or organism." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "pigment metabolic process during pigmentation during development" EXACT []
synonym: "pigment metabolism during developmental pigmentation" EXACT []
synonym: "pigment metabolism during pigmentation during development" EXACT []
is_a: GO:0043474 ! pigment metabolic process during pigmentation
relationship: part_of GO:0048066 ! pigmentation during development

[Term]
id: GO:0043325
name: phosphatidylinositol-3,4-bisphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a diphosphorylated derivative of phosphatidylinositol." [GOC:go_curators]
is_a: GO:0035091 ! phosphoinositide binding

[Term]
id: GO:0043326
name: chemotaxis to folate
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to the presence of folate." [GOC:go_curators]
is_a: GO:0006935 ! chemotaxis
is_a: GO:0051593 ! response to folic acid

[Term]
id: GO:0043327
name: chemotaxis to cAMP
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP." [GOC:go_curators]
synonym: "chemotaxis to 3',5' cAMP" EXACT []
synonym: "chemotaxis to 3',5'-cAMP" EXACT []
synonym: "chemotaxis to adenosine 3',5'-cyclophosphate" EXACT []
synonym: "chemotaxis to cyclic AMP" EXACT []
is_a: GO:0006935 ! chemotaxis

[Term]
id: GO:0043328
name: protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway
namespace: biological_process
def: "The process of directing proteins towards the vacuole using signals contained within the protein, occurring during protein catabolism via the multivesicular body (MVB) pathway." [GOC:jl, PMID:11511343]
synonym: "protein targeting to vacuole during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT []
synonym: "protein targeting to vacuole during ubiquitin-dependent protein degradation via the MVB pathway" EXACT []
synonym: "protein vacuolar targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT []
synonym: "protein vacuolar targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT []
synonym: "protein-vacuolar targeting during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT []
synonym: "protein-vacuolar targeting during ubiquitin-dependent protein degradation via the MVB pathway" EXACT []
synonym: "protein-vacuole targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT []
synonym: "protein-vacuole targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT []
is_a: GO:0006623 ! protein targeting to vacuole
is_a: GO:0032511 ! late endosome to vacuole transport via multivesicular body sorting pathway
relationship: part_of GO:0043162 ! ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

[Term]
id: GO:0043329
name: protein targeting to membrane during ubiquitin-dependent protein catabolic process via the MVB pathway
namespace: biological_process
def: "The process of directing proteins towards a membrane using signals contained within the protein, occurring during ubiquitin-dependent protein catabolism via the MVB pathway; the destruction of a protein or peptide covalently tagged with a ubiquitin, via the multivesicular body (MVB) sorting pathway." [GOC:jl]
synonym: "protein membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT []
synonym: "protein membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT []
synonym: "protein targeting to membrane during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT []
synonym: "protein targeting to membrane during ubiquitin-dependent protein degradation via the MVB pathway" EXACT []
synonym: "protein-membrane targeting during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT []
synonym: "protein-membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT []
synonym: "protein-membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT []
synonym: "protein-membrane targeting during ubiquitin-dependent protein degradation via the MVB pathway" EXACT []
is_a: GO:0006612 ! protein targeting to membrane
relationship: part_of GO:0043162 ! ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

[Term]
id: GO:0043330
name: response to exogenous dsRNA
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:go_curators]
comment: Note that the presence of exogenous double-stranded RNA is usually indicative of a viral infection. Consider also annotating to 'response to virus ; GO:0009615'.
synonym: "response to exogenous double-stranded RNA" EXACT []
synonym: "response to viral dsRNA" NARROW []
is_a: GO:0043331 ! response to dsRNA

[Term]
id: GO:0043331
name: response to dsRNA
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus." [GOC:jl]
synonym: "response to double-stranded RNA" EXACT []
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0043332
name: mating projection tip
namespace: cellular_component
def: "The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth." [GOC:mcc]
synonym: "conjugation tube tip" NARROW []
synonym: "shmoo tip" NARROW []
is_a: GO:0030427 ! site of polarized growth
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0005937 ! mating projection

[Term]
id: GO:0043333
name: 2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9045837]
comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used.
synonym: "2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

[Term]
id: GO:0043334
name: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048]
comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used.
synonym: "2-hexaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

[Term]
id: GO:0043335
name: protein unfolding
namespace: biological_process
def: "The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state." [GOC:mlg]
is_a: GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0043336
name: site-specific telomere resolvase activity
namespace: molecular_function
def: "Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases." [GOC:jl, PMID:11804598]
comment: Note that while this enzyme uses a similar reaction chemistry to topoisomerases and site-specific recombinases, it performs a unique reaction. Topoisomerases promote breakage and reunion of either one or two DNA strands to alter the topological state of a DNA molecule. Site-specific recombinases perform a more complex reaction in which four strands are broken and subsequently joined to a different DNA duplex, resulting in the production of a recombinant product. The telomere resolvases on the other hand, must break two phosphodiester bonds in a single DNA duplex (one on each strand) and join each end with the opposite DNA strand to form covalently closed hairpin telomeres.
synonym: "ResT" NARROW []
synonym: "TelN" NARROW []
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0043337
name: CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol (cardiolipin)." [GOC:jl]
synonym: "cardiolipin synthase" BROAD []
synonym: "cardiolipin synthetase" BROAD []
xref: MetaCyc:RXN-8141
is_a: GO:0030572 ! phosphatidyltransferase activity

[Term]
id: GO:0043338
name: CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol." [GOC:jl, PMID:10960477]
synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase" BROAD []
xref: EC:2.7.7.-
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0043353
name: enucleate erythrocyte differentiation
namespace: biological_process
def: "The process by which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus." [GOC:go_curators]
synonym: "enucleate RBC differentiation" EXACT [CL:0000232]
synonym: "enucleate red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0043354
name: enucleate erythrocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus." [GOC:go_curators]
synonym: "enucleate RBC maturation" EXACT [CL:0000232]
synonym: "enucleate red blood cell maturation" EXACT [CL:0000232]
is_a: GO:0043249 ! erythrocyte maturation
relationship: part_of GO:0048822 ! enucleate erythrocyte development

[Term]
id: GO:0043362
name: nucleate erythrocyte maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus." [GOC:devbiol, GOC:jl]
synonym: "nucleate RBC maturation" EXACT [CL:0000232]
synonym: "nucleate red blood cell maturation" EXACT [CL:0000232]
is_a: GO:0043249 ! erythrocyte maturation
relationship: part_of GO:0048823 ! nucleate erythrocyte development

[Term]
id: GO:0043363
name: nucleate erythrocyte differentiation
namespace: biological_process
def: "The process by which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds." [GOC:jl]
synonym: "nucleate RBC differentiation" EXACT [CL:0000232]
synonym: "nucleate red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0043364
name: catalysis of free radical formation
namespace: molecular_function
def: "Catalysis of a reaction that generates a free radical, a highly reactive molecule with an unsatisfied electron valence pair." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: goslim_pir
synonym: "catalysis of free radical generation" EXACT []
synonym: "catalysis of free-radical biosynthesis" EXACT []
synonym: "catalysis of free-radical formation" EXACT []
synonym: "catalysis of free-radical generation" EXACT []
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0043365
name: [formate-C-acetyltransferase]-activating enzyme activity
namespace: molecular_function
alt_id: GO:0008862
def: "Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical." [EC:1.97.1.4, GOC:jl, PMID:18307109]
synonym: "[pyruvate formate-lyase]-activating enzyme activity" EXACT [EC:1.97.1.4]
synonym: "formate acetyltransferase activating enzyme activity" EXACT [EC:1.97.1.4]
synonym: "formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving) activity" EXACT [EC:1.97.1.4]
synonym: "formate C-acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving)" EXACT [EC:1.97.1.4]
synonym: "formate-C-acetyltransferase-activating enzyme" RELATED [EC:1.97.1.4]
synonym: "PFL activase activity" EXACT [EC:1.97.1.4]
synonym: "PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving) activity" EXACT [EC:1.97.1.4]
synonym: "pyruvate formate-lyase-activating enzyme" RELATED [EC:1.97.1.4]
xref: EC:1.97.1.4
xref: MetaCyc:TDCEACT-RXN
is_a: GO:0016491 ! oxidoreductase activity
is_a: GO:0043364 ! catalysis of free radical formation
is_a: GO:0070283 ! radical SAM enzyme activity

[Term]
id: GO:0043366
name: beta selection
namespace: biological_process
def: "The process by which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell." [ISBN:0781735149 "Fundamental Immunology", PMID:12220932]
is_a: GO:0045058 ! T cell selection
relationship: part_of GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0043367
name: CD4-positive, alpha beta T cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "CD4-positive, alpha-beta T lymphocyte differentiation" EXACT []
synonym: "CD4-positive, alpha-beta T-cell differentiation" EXACT []
synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation" EXACT []
is_a: GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0043368
name: positive T cell selection
namespace: biological_process
def: "The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722]
synonym: "positive T lymphocyte selection" EXACT []
synonym: "positive T-cell selection" EXACT []
synonym: "positive T-lymphocyte selection" EXACT []
is_a: GO:0045058 ! T cell selection

[Term]
id: GO:0043369
name: CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
namespace: biological_process
def: "The process by which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "CD4-positive or CD8-positive, alpha-beta T lymphocyte lineage commitment" EXACT []
synonym: "CD4-positive or CD8-positive, alpha-beta T-cell lineage commitment" EXACT []
synonym: "CD4-positive or CD8-positive, alpha-beta T-lymphocyte lineage commitment" EXACT []
synonym: "CD4-positive/CD8-positive, alpha-beta T cell lineage commitment" EXACT []
is_a: GO:0002360 ! T cell lineage commitment
relationship: part_of GO:0043368 ! positive T cell selection

[Term]
id: GO:0043370
name: regulation of CD4-positive, alpha beta T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of CD4-positive, alpha beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "regulation of CD4-positive T lymphocyte differentiation" EXACT []
synonym: "regulation of CD4-positive T-cell differentiation" EXACT []
synonym: "regulation of CD4-positive T-lymphocyte differentiation" EXACT []
synonym: "regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "regulation of CD4-positive, alpha beta T-cell differentiation" EXACT []
synonym: "regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT []
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation
relationship: regulates GO:0043367 ! CD4-positive, alpha beta T cell differentiation

[Term]
id: GO:0043371
name: negative regulation of CD4-positive, alpha beta T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate, or extent of CD4-positive, alpha beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of CD4-positive, alpha beta T cell differentiation" EXACT []
synonym: "down-regulation of CD4-positive, alpha beta T cell differentiation" EXACT []
synonym: "downregulation of CD4-positive, alpha beta T cell differentiation" EXACT []
synonym: "inhibition of CD4-positive, alpha beta T cell differentiation" NARROW []
synonym: "negative regulation of CD4-positive T lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD4-positive T-cell differentiation" EXACT []
synonym: "negative regulation of CD4-positive T-lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD4-positive, alpha beta T-cell differentiation" EXACT []
synonym: "negative regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT []
is_a: GO:0043370 ! regulation of CD4-positive, alpha beta T cell differentiation
is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation
relationship: negatively_regulates GO:0043367 ! CD4-positive, alpha beta T cell differentiation

[Term]
id: GO:0043372
name: positive regulation of CD4-positive, alpha beta T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of CD4-positive, alpha beta T cell differentiation" NARROW []
synonym: "positive regulation of CD4-positive T lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD4-positive T-cell differentiation" EXACT []
synonym: "positive regulation of CD4-positive T-lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD4-positive, alpha beta T-cell differentiation" EXACT []
synonym: "positive regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT []
synonym: "stimulation of CD4-positive, alpha beta T cell differentiation" NARROW []
synonym: "up regulation of CD4-positive, alpha beta T cell differentiation" EXACT []
synonym: "up-regulation of CD4-positive, alpha beta T cell differentiation" EXACT []
synonym: "upregulation of CD4-positive, alpha beta T cell differentiation" EXACT []
is_a: GO:0043370 ! regulation of CD4-positive, alpha beta T cell differentiation
is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation
relationship: positively_regulates GO:0043367 ! CD4-positive, alpha beta T cell differentiation

[Term]
id: GO:0043373
name: CD4-positive, alpha-beta T cell lineage commitment
namespace: biological_process
def: "The process by which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "CD4-positive, alpha-beta T lymphocyte lineage commitment" EXACT []
synonym: "CD4-positive, alpha-beta T-cell lineage commitment" EXACT []
synonym: "CD4-positive, alpha-beta T-lymphocyte lineage commitment" EXACT []
is_a: GO:0043369 ! CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
relationship: part_of GO:0043367 ! CD4-positive, alpha beta T cell differentiation

[Term]
id: GO:0043374
name: CD8-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "CD8-positive, alpha-beta T lymphocyte differentiation" EXACT []
synonym: "CD8-positive, alpha-beta T-cell differentiation" EXACT []
synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation" EXACT []
is_a: GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0043375
name: CD8-positive, alpha-beta T cell lineage commitment
namespace: biological_process
def: "The process by which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "CD8-positive, alpha-beta T cell fate commitment" EXACT []
synonym: "CD8-positive, alpha-beta T lymphocyte lineage commitment" EXACT []
synonym: "CD8-positive, alpha-beta T-cell lineage commitment" EXACT []
synonym: "CD8-positive, alpha-beta T-lymphocyte lineage commitment" EXACT []
is_a: GO:0043369 ! CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
relationship: part_of GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043376
name: regulation of CD8-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "regulation of CD8-positive T lymphocyte differentiation" EXACT []
synonym: "regulation of CD8-positive T-cell differentiation" EXACT []
synonym: "regulation of CD8-positive T-lymphocyte differentiation" EXACT []
synonym: "regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "regulation of CD8-positive, alpha beta T-cell differentiation" EXACT []
synonym: "regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT []
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation
relationship: regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043377
name: negative regulation of CD8-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
synonym: "down-regulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
synonym: "downregulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
synonym: "inhibition of CD8-positive, alpha-beta T cell differentiation" NARROW []
synonym: "negative regulation of CD8-positive T lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD8-positive T-cell differentiation" EXACT []
synonym: "negative regulation of CD8-positive T-lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "negative regulation of CD8-positive, alpha beta T-cell differentiation" EXACT []
synonym: "negative regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT []
is_a: GO:0043376 ! regulation of CD8-positive, alpha-beta T cell differentiation
is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation
relationship: negatively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043378
name: positive regulation of CD8-positive, alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of CD8-positive, alpha-beta T cell differentiation" NARROW []
synonym: "positive regulation of CD8-positive T lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD8-positive T-cell differentiation" EXACT []
synonym: "positive regulation of CD8-positive T-lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT []
synonym: "positive regulation of CD8-positive, alpha beta T-cell differentiation" EXACT []
synonym: "positive regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT []
synonym: "stimulation of CD8-positive, alpha-beta T cell differentiation" NARROW []
synonym: "up regulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
synonym: "up-regulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
synonym: "upregulation of CD8-positive, alpha-beta T cell differentiation" EXACT []
is_a: GO:0043376 ! regulation of CD8-positive, alpha-beta T cell differentiation
is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation
relationship: positively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation

[Term]
id: GO:0043379
name: memory T cell differentiation
namespace: biological_process
def: "The process whereby a newly activated T cell acquires specialized features of a memory T cell." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "memory T lymphocyte differentiation" EXACT []
synonym: "memory T-cell differentiation" EXACT []
synonym: "memory T-lymphocyte differentiation" EXACT []
is_a: GO:0002292 ! T cell differentiation during immune response

[Term]
id: GO:0043380
name: regulation of memory T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of memory T cell differentiation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "regulation of memory T lymphocyte differentiation" EXACT []
synonym: "regulation of memory T-cell differentiation" EXACT []
synonym: "regulation of memory T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0043379 ! memory T cell differentiation

[Term]
id: GO:0043381
name: negative regulation of memory T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of memory T cell differentiation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of memory T cell differentiation" EXACT []
synonym: "down-regulation of memory T cell differentiation" EXACT []
synonym: "downregulation of memory T cell differentiation" EXACT []
synonym: "inhibition of memory T cell differentiation" NARROW []
synonym: "negative regulation of memory T lymphocyte differentiation" EXACT []
synonym: "negative regulation of memory T-cell differentiation" EXACT []
synonym: "negative regulation of memory T-lymphocyte differentiation" EXACT []
is_a: GO:0043380 ! regulation of memory T cell differentiation
is_a: GO:0045581 ! negative regulation of T cell differentiation
relationship: negatively_regulates GO:0043379 ! memory T cell differentiation

[Term]
id: GO:0043382
name: positive regulation of memory T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of memory T cell differentiation." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of memory T cell differentiation" NARROW []
synonym: "positive regulation of memory T lymphocyte differentiation" EXACT []
synonym: "positive regulation of memory T-cell differentiation" EXACT []
synonym: "positive regulation of memory T-lymphocyte differentiation" EXACT []
synonym: "stimulation of memory T cell differentiation" NARROW []
synonym: "up regulation of memory T cell differentiation" EXACT []
synonym: "up-regulation of memory T cell differentiation" EXACT []
synonym: "upregulation of memory T cell differentiation" EXACT []
is_a: GO:0043380 ! regulation of memory T cell differentiation
is_a: GO:0045582 ! positive regulation of T cell differentiation
relationship: positively_regulates GO:0043379 ! memory T cell differentiation

[Term]
id: GO:0043383
name: negative T cell selection
namespace: biological_process
def: "The process of elimination of immature T cells which react strongly with self-antigens." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722]
synonym: "negative T lymphocyte selection" EXACT []
synonym: "negative T-cell selection" EXACT []
synonym: "negative T-lymphocyte selection" EXACT []
is_a: GO:0045058 ! T cell selection

[Term]
id: GO:0043384
name: pre-T cell receptor complex
namespace: cellular_component
def: "A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins." [ISBN:0781735149 "Fundamental Immunology", PMID:12220932]
synonym: "pre-T lymphocyte receptor complex" EXACT []
synonym: "pre-T-cell receptor complex" EXACT []
synonym: "pre-T-lymphocyte receptor complex" EXACT []
synonym: "pre-TCR complex" EXACT []
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0043385
name: mycotoxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "mycotoxin metabolism" EXACT []
is_a: GO:0009404 ! toxin metabolic process

[Term]
id: GO:0043386
name: mycotoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "mycotoxin anabolism" EXACT []
synonym: "mycotoxin biosynthesis" EXACT []
synonym: "mycotoxin formation" EXACT []
synonym: "mycotoxin synthesis" EXACT []
is_a: GO:0009403 ! toxin biosynthetic process
is_a: GO:0043385 ! mycotoxin metabolic process

[Term]
id: GO:0043387
name: mycotoxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "mycotoxin breakdown" EXACT []
synonym: "mycotoxin catabolism" EXACT []
synonym: "mycotoxin degradation" EXACT []
is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0043385 ! mycotoxin metabolic process

[Term]
id: GO:0043388
name: positive regulation of DNA binding
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
subset: gosubset_prok
synonym: "activation of DNA binding" NARROW []
synonym: "stimulation of DNA binding" NARROW []
synonym: "up regulation of DNA binding" EXACT []
synonym: "up-regulation of DNA binding" EXACT []
synonym: "upregulation of DNA binding" EXACT []
is_a: GO:0051099 ! positive regulation of binding
is_a: GO:0051101 ! regulation of DNA binding

[Term]
id: GO:0043389
name: aflatoxin B metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aflatoxins with a B designation. Distinguished from other aflatoxins by their exhibition of blue fluorescence under UV-light." [GOC:jl, http://www.ansci.cornell.edu/plants/toxicagents/aflatoxin/aflatoxin.html]
synonym: "aflatoxin B metabolism" EXACT []
is_a: GO:0046222 ! aflatoxin metabolic process

[Term]
id: GO:0043390
name: aflatoxin B1 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aflatoxin B1, a potent hepatotoxic and hepatocarcinogenic mycotoxin produced by various species from the Aspergillus group of fungi." [GOC:jl, http://cancerweb.ncl.ac.uk/]
synonym: "aflatoxin B1 metabolism" EXACT []
is_a: GO:0043389 ! aflatoxin B metabolic process

[Term]
id: GO:0043391
name: aflatoxin B2 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aflatoxin B2, a mycotoxin produced by the fungal species Aspergillus flavus, Aspergillus parasiticus and Aspergillus nomius." [GOC:jl, http://www.aspergillus.man.ac.uk/]
synonym: "aflatoxin B2 metabolism" EXACT []
is_a: GO:0043389 ! aflatoxin B metabolic process

[Term]
id: GO:0043392
name: negative regulation of DNA binding
namespace: biological_process
def: "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of DNA binding" EXACT []
synonym: "down-regulation of DNA binding" EXACT []
synonym: "downregulation of DNA binding" EXACT []
synonym: "inhibition of DNA binding" NARROW []
is_a: GO:0051100 ! negative regulation of binding
is_a: GO:0051101 ! regulation of DNA binding

[Term]
id: GO:0043393
name: regulation of protein binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:0043394
name: proteoglycan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0001948 ! glycoprotein binding

[Term]
id: GO:0043395
name: heparan sulfate proteoglycan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "heparin proteoglycan binding" RELATED []
is_a: GO:0043394 ! proteoglycan binding

[Term]
id: GO:0043396
name: corticotropin-releasing hormone secretion
namespace: biological_process
def: "The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce adrenocorticotrophic hormone (ACTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle." [GOC:go_curators, PMID:11027914]
synonym: "corticotropin-releasing factor secretion" EXACT []
synonym: "CRF secretion" EXACT []
synonym: "CRH secretion" EXACT []
is_a: GO:0046879 ! hormone secretion

[Term]
id: GO:0043397
name: regulation of corticotropin-releasing hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion." [GOC:go_curators, PMID:11027914]
synonym: "regulation of corticotropin-releasing factor secretion" EXACT []
synonym: "regulation of CRF secretion" EXACT []
synonym: "regulation of CRH secretion" EXACT []
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0043396 ! corticotropin-releasing hormone secretion

[Term]
id: GO:0043398
name: HLH domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization." [GOC:go_curators, Prosite:PDOC0038]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0043399
name: tRNA A64-2'-O-ribosylphosphate transferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA." [GOC:jl, PMID:7954819]
synonym: "initiator tRNA phosphoribosyl-transferase activity" EXACT []
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0043400
name: cortisol secretion
namespace: biological_process
def: "The regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland." [PMID:11027914]
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0043401
name: steroid hormone mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by the detection of a steroid hormone." [PMID:12606724]
synonym: "steroid hormone mediated signalling" EXACT []
is_a: GO:0009755 ! hormone-mediated signaling pathway
is_a: GO:0071383 ! cellular response to steroid hormone stimulus

[Term]
id: GO:0043402
name: glucocorticoid mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by the detection of a glucocorticoid hormone." [PMID:15240347]
synonym: "glucocorticoid mediated signalling" EXACT []
is_a: GO:0043401 ! steroid hormone mediated signaling pathway
is_a: GO:0071385 ! cellular response to glucocorticoid stimulus

[Term]
id: GO:0043403
name: skeletal muscle tissue regeneration
namespace: biological_process
def: "The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:ef, GOC:mtg_muscle, PMID:12021255, PMID:16607119]
synonym: "myofiber turnover" RELATED []
is_a: GO:0042246 ! tissue regeneration

[Term]
id: GO:0043404
name: corticotropin-releasing hormone receptor activity
namespace: molecular_function
def: "Combining with corticotropin-releasing hormone to initiate a change in cell activity." [ISBN:0838577016, PMID:11027914, PMID:15134857]
is_a: GO:0004872 ! receptor activity
is_a: GO:0051424 ! corticotropin-releasing hormone binding

[Term]
id: GO:0043405
name: regulation of MAP kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]
synonym: "Regulation of MAPK activity" EXACT [GOC:dph]
synonym: "regulation of mitogen activated protein kinase activity" EXACT []
synonym: "regulation of mitogen-activated protein kinase activity" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0045859 ! regulation of protein kinase activity

[Term]
id: GO:0043406
name: positive regulation of MAP kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]
synonym: "positive regulation of mitogen activated protein kinase activity" EXACT []
synonym: "positive regulation of mitogen-activated protein kinase activity" EXACT []
synonym: "stimulation of MAPK activity" NARROW []
synonym: "up regulation of MAPK activity" EXACT []
synonym: "up-regulation of MAPK activity" EXACT []
synonym: "upregulation of MAPK activity" EXACT []
is_a: GO:0043405 ! regulation of MAP kinase activity
is_a: GO:0045860 ! positive regulation of protein kinase activity

[Term]
id: GO:0043407
name: negative regulation of MAP kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]
synonym: "down regulation of MAPK activity" EXACT []
synonym: "down-regulation of MAPK activity" EXACT []
synonym: "downregulation of MAPK activity" EXACT []
synonym: "inhibition of MAPK activity" NARROW []
synonym: "negative regulation of mitogen activated protein kinase activity" EXACT []
synonym: "negative regulation of mitogen-activated protein kinase activity" EXACT []
is_a: GO:0006469 ! negative regulation of protein kinase activity
is_a: GO:0043405 ! regulation of MAP kinase activity

[Term]
id: GO:0043408
name: regulation of MAPKKK cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators]
synonym: "regulation of MAP kinase kinase kinase cascade" EXACT []
synonym: "regulation of mitogen activated protein kinase kinase kinase cascade" EXACT []
synonym: "regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT []
is_a: GO:0010627 ! regulation of protein kinase cascade
relationship: regulates GO:0000165 ! MAPKKK cascade

[Term]
id: GO:0043409
name: negative regulation of MAPKKK cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators]
synonym: "down regulation of MAPKKK cascade" EXACT []
synonym: "down-regulation of MAPKKK cascade" EXACT []
synonym: "downregulation of MAPKKK cascade" EXACT []
synonym: "inhibition of MAPKKK cascade" NARROW []
synonym: "negative regulation of MAP kinase kinase kinase cascade" EXACT []
synonym: "negative regulation of mitogen activated protein kinase kinase kinase cascade" EXACT []
synonym: "negative regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT []
is_a: GO:0010741 ! negative regulation of protein kinase cascade
is_a: GO:0043408 ! regulation of MAPKKK cascade
relationship: negatively_regulates GO:0000165 ! MAPKKK cascade

[Term]
id: GO:0043410
name: positive regulation of MAPKKK cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]
synonym: "activation of MAPKKK cascade" NARROW []
synonym: "positive regulation of MAP kinase kinase kinase cascade" EXACT []
synonym: "positive regulation of mitogen activated protein kinase kinase kinase cascade" EXACT []
synonym: "positive regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT []
synonym: "stimulation of MAPKKK cascade" NARROW []
synonym: "up regulation of MAPKKK cascade" EXACT []
synonym: "up-regulation of MAPKKK cascade" EXACT []
synonym: "upregulation of MAPKKK cascade" EXACT []
is_a: GO:0010740 ! positive regulation of protein kinase cascade
is_a: GO:0043408 ! regulation of MAPKKK cascade
relationship: positively_regulates GO:0000165 ! MAPKKK cascade

[Term]
id: GO:0043411
name: myopalladin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with myopalladin, a myofibrillar protein with titin-like Ig domains." [GOC:go_curators]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0043412
name: macromolecule modification
namespace: biological_process
def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0043413
name: macromolecule glycosylation
namespace: biological_process
def: "The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:jl]
subset: gosubset_prok
is_a: GO:0043412 ! macromolecule modification
is_a: GO:0070085 ! glycosylation

[Term]
id: GO:0043414
name: macromolecule methylation
namespace: biological_process
def: "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0032259 ! methylation
is_a: GO:0043412 ! macromolecule modification
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0043415
name: positive regulation of skeletal muscle tissue regeneration
namespace: biological_process
def: "Any process that activates or increase the rate of skeletal muscle regeneration." [GOC:jl]
synonym: "activation of skeletal muscle regeneration" NARROW []
synonym: "stimulation of skeletal muscle regeneration" NARROW []
synonym: "up regulation of skeletal muscle regeneration" EXACT []
synonym: "up-regulation of skeletal muscle regeneration" EXACT []
synonym: "upregulation of skeletal muscle regeneration" EXACT []
is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration
is_a: GO:0048639 ! positive regulation of developmental growth
relationship: positively_regulates GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0043416
name: regulation of skeletal muscle tissue regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle." [GOC:jl]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0043417
name: negative regulation of skeletal muscle tissue regeneration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle regeneration." [GOC:jl]
synonym: "down regulation of skeletal muscle regeneration" EXACT []
synonym: "down-regulation of skeletal muscle regeneration" EXACT []
synonym: "downregulation of skeletal muscle regeneration" EXACT []
synonym: "inhibition of skeletal muscle regeneration" NARROW []
is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration
is_a: GO:0048640 ! negative regulation of developmental growth
relationship: negatively_regulates GO:0043403 ! skeletal muscle tissue regeneration

[Term]
id: GO:0043418
name: homocysteine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." [GOC:jl]
synonym: "homocysteine breakdown" EXACT []
synonym: "homocysteine catabolism" EXACT []
synonym: "homocysteine degradation" EXACT []
is_a: GO:0000098 ! sulfur amino acid catabolic process
is_a: GO:0050667 ! homocysteine metabolic process

[Term]
id: GO:0043419
name: urea catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2." [GOC:jl]
synonym: "urea breakdown" EXACT []
synonym: "urea catabolism" EXACT []
synonym: "urea decomposition" EXACT []
synonym: "urea degradation" EXACT []
is_a: GO:0019627 ! urea metabolic process
is_a: GO:0043605 ! cellular amide catabolic process
is_a: GO:0044282 ! small molecule catabolic process

[Term]
id: GO:0043420
name: anthranilate metabolic process
namespace: biological_process
alt_id: GO:0018869
def: "The chemical reactions and pathways involving anthranilate (2-aminobenzoate)." [ChEBI:16567, GOC:jl]
synonym: "2-aminobenzoate metabolic process" EXACT []
synonym: "2-aminobenzoate metabolism" EXACT []
synonym: "anthranilate metabolism" EXACT []
synonym: "anthranilic acid metabolic process" NARROW []
synonym: "anthranilic acid metabolism" NARROW []
synonym: "ortho-aminobenzoic acid metabolic process" NARROW []
synonym: "ortho-aminobenzoic acid metabolism" NARROW []
xref: UM-BBD_pathwayID:abz2
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0018874 ! benzoate metabolic process

[Term]
id: GO:0043421
name: anthranilate catabolic process
namespace: biological_process
alt_id: GO:0019259
def: "The chemical reactions and pathways resulting in the breakdown of anthranilate (2-aminobenzoate)." [ChEBI:16567, GOC:jl]
synonym: "2-aminobenzoate breakdown" EXACT []
synonym: "2-aminobenzoate catabolic process" EXACT []
synonym: "2-aminobenzoate catabolism" NARROW []
synonym: "2-aminobenzoate degradation" EXACT []
synonym: "anthranilate breakdown" EXACT []
synonym: "anthranilate catabolism" EXACT []
synonym: "anthranilate degradation" EXACT []
synonym: "anthranilic acid catabolic process" NARROW []
synonym: "anthranilic acid catabolism" NARROW []
synonym: "ortho-aminobenzoic acid catabolic process" NARROW []
synonym: "ortho-aminobenzoic acid catabolism" NARROW []
xref: MetaCyc:2AMINOBENZDEG-PWY
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043420 ! anthranilate metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0043422
name: protein kinase B binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism." [GOC:jl, http://www.heartandmetabolism.org/]
synonym: "Akt binding" EXACT []
synonym: "PKB binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0043423
name: 3-phosphoinositide-dependent protein kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 3-phosphoinositide-dependent protein kinase." [GOC:jl]
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0043424
name: protein histidine kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with protein histidine kinase." [GOC:jl]
synonym: "histidine kinase binding" EXACT []
synonym: "histidine-protein kinase binding" EXACT []
synonym: "protein-histidine kinase binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0043425
name: bHLH transcription factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transciptional networks of many developmental pathways." [PMID:9144210]
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0043426
name: MRF binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors." [PMID:10966875]
is_a: GO:0043425 ! bHLH transcription factor binding

[Term]
id: GO:0043427
name: carbon fixation by 3-hydroxypropionate cycle
namespace: biological_process
def: "An autotrophic carbon dioxide fixation pathway by which two molecules of carbon dioxide are fixed to form glyoxylate. Acetyl coenzyme A (acetyl-CoA) is assumed to be converted to malate, and two CO2 molecules are thereby fixed. Malyl-CoA is thought to be cleaved to acetyl-CoA, the starting molecule, and glyoxylate, the carbon fixation product." [GOC:jl, PMID:11418572, PMID:15838028]
synonym: "3-hydroxypropionate cycle" EXACT []
synonym: "3-hydroxypropionate pathway" EXACT []
synonym: "hydroxypropionate cycle" EXACT []
synonym: "hydroxypropionate pathway" EXACT []
is_a: GO:0015977 ! carbon utilization by fixation of carbon dioxide

[Term]
id: GO:0043428
name: 2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838]
comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used.
synonym: "2-heptaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
xref: MetaCyc:RXN-9227
is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

[Term]
id: GO:0043429
name: 2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838]
comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used.
synonym: "2-nonaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

[Term]
id: GO:0043430
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838]
comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used.
synonym: "2-decaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT []
is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

[Term]
id: GO:0043431
name: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838, PMID:1479344]
synonym: "2-octaprenyl-6-hydroxy phenol methylase activity" EXACT []
synonym: "3-demethylubiquinone-9 3-methyltransferase activity" EXACT []
xref: MetaCyc:2.1.1.64-RXN
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0043433
name: negative regulation of transcription factor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl]
synonym: "down regulation of transcription factor activity" EXACT []
synonym: "down-regulation of transcription factor activity" EXACT []
synonym: "downregulation of transcription factor activity" EXACT []
synonym: "inhibition of transcription factor activity" NARROW []
is_a: GO:0043392 ! negative regulation of DNA binding
is_a: GO:0051090 ! regulation of transcription factor activity
is_a: GO:0090048 ! negative regulation of transcription regulator activity

[Term]
id: GO:0043434
name: response to peptide hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone]
synonym: "response to polypeptide hormone stimulus" EXACT []
is_a: GO:0009725 ! response to hormone stimulus

[Term]
id: GO:0043435
name: response to corticotropin-releasing hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response." [PMID:11027914, PMID:15134857, Wikipedia:Corticotropin-releasing_hormone]
synonym: "response to corticoliberin stimulus" EXACT []
synonym: "response to corticotropin-releasing factor stimulus" EXACT []
synonym: "response to CRF stimulus" EXACT []
synonym: "response to CRH stimulus" EXACT []
is_a: GO:0043434 ! response to peptide hormone stimulus

[Term]
id: GO:0043436
name: oxoacid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [ChEBI:24833]
subset: gosubset_prok
synonym: "keto acid metabolic process" EXACT []
synonym: "keto acid metabolism" EXACT []
synonym: "ketoacid metabolic process" EXACT []
synonym: "ketoacid metabolism" EXACT []
synonym: "oxo acid metabolic process" EXACT []
synonym: "oxo acid metabolism" EXACT []
synonym: "oxoacid metabolism" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process

[Term]
id: GO:0043437
name: butanoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any butanoic acid, 4-carbon saturated monocarboxylic acids." [http://cancerweb.ncl.ac.uk/]
synonym: "butanoic acid metabolism" EXACT []
synonym: "butyric acid metabolic process" EXACT []
synonym: "butyric acid metabolism" EXACT []
is_a: GO:0046459 ! short-chain fatty acid metabolic process

[Term]
id: GO:0043438
name: acetoacetic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH." [ChEBI:15344, Wikipedia:Acetoacetic_acid]
synonym: "3-oxobutanoate metabolic process" EXACT []
synonym: "3-oxobutanoate metabolism" EXACT []
synonym: "3-oxobutanoic acid metabolic process" EXACT []
synonym: "3-oxobutanoic acid metabolism" EXACT []
synonym: "acetoacetate metabolic process" EXACT []
synonym: "acetoacetate metabolism" EXACT []
synonym: "acetoacetic acid metabolism" EXACT []
synonym: "beta ketobutyric acid metabolic process" EXACT []
synonym: "beta ketobutyric acid metabolism" EXACT []
synonym: "beta-ketobutyric acid metabolic process" EXACT []
synonym: "beta-ketobutyric acid metabolism" EXACT []
synonym: "diacetic acid metabolic process" EXACT []
synonym: "diacetic acid metabolism" EXACT []
is_a: GO:0043437 ! butanoic acid metabolic process

[Term]
id: GO:0043439
name: butanoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any butanoic acid, 4-carbon saturated monocarboxylic acids." [GOC:jl]
synonym: "butanoic acid anabolism" EXACT []
synonym: "butanoic acid biosynthesis" EXACT []
synonym: "butanoic acid formation" EXACT []
synonym: "butanoic acid synthesis" EXACT []
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0043437 ! butanoic acid metabolic process

[Term]
id: GO:0043440
name: butanoic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any butanoic acid, 4-carbon saturated monocarboxylic acids." [GOC:jl]
synonym: "butanoic acid breakdown" EXACT []
synonym: "butanoic acid catabolism" EXACT []
synonym: "butanoic acid degradation" EXACT []
is_a: GO:0019626 ! short-chain fatty acid catabolic process
is_a: GO:0043437 ! butanoic acid metabolic process

[Term]
id: GO:0043441
name: acetoacetic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [GOC:jl]
synonym: "acetoacetic acid anabolism" EXACT []
synonym: "acetoacetic acid biosynthesis" EXACT []
synonym: "acetoacetic acid formation" EXACT []
synonym: "acetoacetic acid synthesis" EXACT []
xref: Reactome:448511 "Formation of Acetoacetic Acid"
xref: Reactome:469641 "Formation of Acetoacetic Acid"
xref: Reactome:487353 "Formation of Acetoacetic Acid"
xref: Reactome:507304 "Formation of Acetoacetic Acid"
xref: Reactome:517318 "Formation of Acetoacetic Acid"
xref: Reactome:526201 "Formation of Acetoacetic Acid"
xref: Reactome:531087 "Formation of Acetoacetic Acid"
xref: Reactome:536460 "Formation of Acetoacetic Acid"
xref: Reactome:542164 "Formation of Acetoacetic Acid"
xref: Reactome:547522 "Formation of Acetoacetic Acid"
xref: Reactome:552115 "Formation of Acetoacetic Acid"
xref: Reactome:557707 "Formation of Acetoacetic Acid"
xref: Reactome:568322 "Formation of Acetoacetic Acid"
xref: Reactome:581524 "Formation of Acetoacetic Acid"
xref: Reactome:592411 "Formation of Acetoacetic Acid"
xref: Reactome:595294 "Formation of Acetoacetic Acid"
xref: Reactome:597269 "Formation of Acetoacetic Acid"
xref: Reactome:598123 "Formation of Acetoacetic Acid"
xref: Reactome:599610 "Formation of Acetoacetic Acid"
xref: Reactome:602414 "Formation of Acetoacetic Acid"
xref: Reactome:77110 "Formation of Acetoacetic Acid"
is_a: GO:0043438 ! acetoacetic acid metabolic process
is_a: GO:0043439 ! butanoic acid biosynthetic process

[Term]
id: GO:0043442
name: acetoacetic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [GOC:jl]
synonym: "acetoacetic acid breakdown" EXACT []
synonym: "acetoacetic acid catabolism" EXACT []
synonym: "acetoacetic acid degradation" EXACT []
is_a: GO:0043438 ! acetoacetic acid metabolic process
is_a: GO:0043440 ! butanoic acid catabolic process

[Term]
id: GO:0043443
name: acetone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetone, propan-2-one." [GOC:jl]
synonym: "2-propanone metabolic process" EXACT []
synonym: "2-propanone metabolism" EXACT []
synonym: "acetone metabolism" EXACT []
synonym: "dimethyl ketone metabolic process" EXACT []
synonym: "dimethyl ketone metabolism" EXACT []
synonym: "propan-2-one metabolic process" EXACT []
synonym: "propan-2-one metabolism" EXACT []
is_a: GO:0042180 ! cellular ketone metabolic process

[Term]
id: GO:0043444
name: acetone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetone, propan-2-one." [GOC:jl]
synonym: "2-propanone catabolic process" EXACT []
synonym: "2-propanone catabolism" EXACT []
synonym: "acetone breakdown" EXACT []
synonym: "acetone catabolism" EXACT []
synonym: "acetone degradation" EXACT []
synonym: "dimethyl ketone catabolic process" EXACT []
synonym: "dimethyl ketone catabolism" EXACT []
synonym: "propan-2-one catabolic process" EXACT []
synonym: "propan-2-one catabolism" EXACT []
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0043443 ! acetone metabolic process

[Term]
id: GO:0043445
name: acetone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetone, propan-2-one." [GOC:jl]
synonym: "2-propanone biosynthesis" EXACT []
synonym: "2-propanone biosynthetic process" EXACT []
synonym: "acetone anabolism" EXACT []
synonym: "acetone biosynthesis" EXACT []
synonym: "acetone formation" EXACT []
synonym: "acetone synthesis" EXACT []
synonym: "dimethyl ketone biosynthesis" EXACT []
synonym: "dimethyl ketone biosynthetic process" EXACT []
synonym: "propan-2-one biosynthesis" EXACT []
synonym: "propan-2-one biosynthetic process" EXACT []
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0043443 ! acetone metabolic process

[Term]
id: GO:0043446
name: cellular alkane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, as carried out by individual cells." [ChEBI:18310, GOC:jl, Wikipedia:Alkane]
subset: goslim_pir
subset: gosubset_prok
synonym: "alkane metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0043447
name: alkane biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2." [ChEBI:18310, GOC:jl, Wikipedia:Alkane]
subset: gosubset_prok
synonym: "alkane anabolism" EXACT []
synonym: "alkane biosynthesis" EXACT []
synonym: "alkane formation" EXACT []
synonym: "alkane synthesis" EXACT []
is_a: GO:0043446 ! cellular alkane metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0043448
name: alkane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2." [ChEBI:18310, GOC:jl, Wikipedia:Alkane]
subset: gosubset_prok
synonym: "alkane breakdown" EXACT []
synonym: "alkane catabolism" EXACT []
synonym: "alkane degradation" EXACT []
is_a: GO:0043446 ! cellular alkane metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0043449
name: cellular alkene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an alkene, any cyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n, as carried out by individual cells." [ChEBI:32878, GOC:jl, Wikipedia:Alkene]
subset: goslim_pir
subset: gosubset_prok
synonym: "alkene metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0043450
name: alkene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an alkene, any cyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [ChEBI:32878, GOC:jl, Wikipedia:Alkene]
subset: gosubset_prok
synonym: "alkene anabolism" EXACT []
synonym: "alkene biosynthesis" EXACT []
synonym: "alkene formation" EXACT []
synonym: "alkene synthesis" EXACT []
is_a: GO:0043449 ! cellular alkene metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0043451
name: alkene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an alkene, any cyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [ChEBI:32878, GOC:jl, Wikipedia:Alkene]
subset: gosubset_prok
synonym: "alkene breakdown" EXACT []
synonym: "alkene catabolism" EXACT []
synonym: "alkene degradation" EXACT []
is_a: GO:0043449 ! cellular alkene metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0043452
name: cellular alkyne metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an alkyne, any cyclic branched or unbranched hydrocarbon having a carbon-carbon triple bond and the general formula CnH2n-2, as carried out by individual cells." [ChEBI:22339, GOC:jl, Wikipedia:Alkyne]
subset: goslim_pir
subset: gosubset_prok
synonym: "alkyne metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0043453
name: alkyne biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an alkyne, any cyclic branched or unbranched hydrocarbon having a carbon-carbon triple bond and the general formula CnH2n-2." [ChEBI:22339, GOC:jl, Wikipedia:Alkyne]
synonym: "alkyne anabolism" EXACT []
synonym: "alkyne biosynthesis" EXACT []
synonym: "alkyne formation" EXACT []
synonym: "alkyne synthesis" EXACT []
is_a: GO:0043452 ! cellular alkyne metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0043454
name: alkyne catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an alkyne, any cyclic branched or unbranched hydrocarbons having a carbon-carbon triple bond and the general formula CnH2n-2." [ChEBI:22339, GOC:jl, Wikipedia:Alkyne]
subset: gosubset_prok
synonym: "alkyne breakdown" EXACT []
synonym: "alkyne catabolism" EXACT []
synonym: "alkyne degradation" EXACT []
is_a: GO:0043452 ! cellular alkyne metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0043455
name: regulation of secondary metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]
synonym: "regulation of secondary metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0019748 ! secondary metabolic process

[Term]
id: GO:0043456
name: regulation of pentose-phosphate shunt
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process by which glucose is oxidized, coupled to NADPH synthesis." [GOC:jl]
synonym: "regulation of pentose phosphate pathway" EXACT []
synonym: "regulation of pentose phosphate shunt" EXACT []
synonym: "regulation of pentose-phosphate pathway" EXACT []
is_a: GO:0006140 ! regulation of nucleotide metabolic process
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0034248 ! regulation of cellular amide metabolic process
is_a: GO:0043455 ! regulation of secondary metabolic process
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
relationship: regulates GO:0006098 ! pentose-phosphate shunt

[Term]
id: GO:0043457
name: regulation of cellular respiration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds." [GOC:jl]
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
relationship: regulates GO:0045333 ! cellular respiration

[Term]
id: GO:0043458
name: ethanol biosynthetic process during fermentation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, during the process of fermentation." [GOC:jl]
synonym: "ethanol anabolism during fermentation" EXACT []
synonym: "ethanol formation during fermentation" EXACT []
synonym: "ethanol synthesis during fermentation" EXACT []
is_a: GO:0006115 ! ethanol biosynthetic process
relationship: part_of GO:0019655 ! glucose catabolic process to ethanol

[Term]
id: GO:0043459
name: response to short exposure to lithium ion
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a single or short exposure to a lithium ion stimulus." [PMID:10208444]
comment: This term was made obsolete because 'short' is not a quantitative or meaningful measurement of time.
is_obsolete: true

[Term]
id: GO:0043460
name: response to long exposure to lithium ion
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a long or persistent exposure to a lithium ion stimulus." [PMID:10208444]
comment: This term was made obsolete because 'long' is not a quantitative or meaningful measurement of time.
is_obsolete: true

[Term]
id: GO:0043461
name: proton-transporting ATP synthase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes." [GOC:jl, GOC:mah, http://www.mblab.gla.ac.uk/]
subset: gosubset_prok
synonym: "F-type ATPase complex assembly" EXACT []
is_a: GO:0070071 ! proton-transporting two-sector ATPase complex assembly
relationship: part_of GO:0070272 ! proton-transporting ATP synthase complex biogenesis

[Term]
id: GO:0043462
name: regulation of ATPase activity
namespace: biological_process
def: "Any process that modulates the rate of ATP hydrolysis by an ATPase." [GOC:jl]
synonym: "regulation of adenosinetriphosphatase activity" EXACT []
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0043463
name: regulation of rhamnose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose." [GOC:jl]
synonym: "regulation of rhamnose breakdown" EXACT []
synonym: "regulation of rhamnose catabolism" EXACT []
synonym: "regulation of rhamnose degradation" EXACT []
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
relationship: regulates GO:0019301 ! rhamnose catabolic process

[Term]
id: GO:0043464
name: malolactic fermentation
namespace: biological_process
def: "The anaerobic enzymatic conversion of L-malate to L-lactate and carbon dioxide, yielding energy in the form of ATP." [PMID:10427020, PMID:8808948]
synonym: "L-malate fermentation" BROAD []
synonym: "malate fermentation" BROAD []
synonym: "malo-lactate fermentation" EXACT []
synonym: "malolactate fermentation" EXACT []
xref: Wikipedia:Malolactic_fermentation
is_a: GO:0006113 ! fermentation

[Term]
id: GO:0043465
name: regulation of fermentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fermentation, the anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, resulting in energy in the form of adenosine triphosphate (ATP)." [GOC:jl]
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
relationship: regulates GO:0006113 ! fermentation

[Term]
id: GO:0043466
name: pyrimidine fermentation
namespace: biological_process
def: "The anaerobic conversion of pyrimidines, yielding energy in the form of ATP." [GOC:jl]
is_a: GO:0006208 ! pyrimidine base catabolic process
is_a: GO:0019666 ! nitrogenous compound catabolic process

[Term]
id: GO:0043467
name: regulation of generation of precursor metabolites and energy
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." [GOC:jl]
is_a: GO:0031323 ! regulation of cellular metabolic process
relationship: regulates GO:0006091 ! generation of precursor metabolites and energy

[Term]
id: GO:0043468
name: regulation of fucose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of fucose." [GOC:mlg]
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
relationship: regulates GO:0019317 ! fucose catabolic process

[Term]
id: GO:0043469
name: regulation of D-xylose catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of xylose." [GOC:mlg]
is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process
relationship: regulates GO:0042843 ! D-xylose catabolic process

[Term]
id: GO:0043470
name: regulation of carbohydrate catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009894 ! regulation of catabolic process
relationship: regulates GO:0016052 ! carbohydrate catabolic process

[Term]
id: GO:0043471
name: regulation of cellular carbohydrate catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells." [GOC:jl]
subset: gosubset_prok
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0043470 ! regulation of carbohydrate catabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0044275 ! cellular carbohydrate catabolic process

[Term]
id: GO:0043472
name: IgD binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an immunoglobulin of a D isotype." [PMID:12886015]
is_a: GO:0019865 ! immunoglobulin binding

[Term]
id: GO:0043473
name: pigmentation
namespace: biological_process
def: "The deposition or aggregation of coloring matter in an organism, tissue or cell." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0043474
name: pigment metabolic process during pigmentation
namespace: biological_process
def: "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, occurring during the deposition or aggregation of pigment in an organism, tissue or cell." [GOC:jl]
synonym: "pigment metabolism during pigmentation" EXACT []
is_a: GO:0042440 ! pigment metabolic process
relationship: part_of GO:0043473 ! pigmentation

[Term]
id: GO:0043475
name: pigment metabolic process during pigment accumulation
namespace: biological_process
def: "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, occurring during pigment accumulation." [GOC:jl]
synonym: "pigment metabolism during pigment accumulation" EXACT []
is_a: GO:0043474 ! pigment metabolic process during pigmentation
relationship: part_of GO:0043476 ! pigment accumulation

[Term]
id: GO:0043476
name: pigment accumulation
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus." [GOC:jl]
synonym: "pigment accumulation in response to external stimulus" EXACT []
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0043473 ! pigmentation

[Term]
id: GO:0043477
name: pigment biosynthetic process during pigment accumulation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, occurring during pigment accumulation." [GOC:jl]
is_a: GO:0043475 ! pigment metabolic process during pigment accumulation
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0043478
name: pigment accumulation in response to UV light
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to a UV light stimulus." [GOC:jl]
is_a: GO:0009411 ! response to UV
is_a: GO:0043476 ! pigment accumulation

[Term]
id: GO:0043479
name: pigment accumulation in tissues in response to UV light
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in a tissue, occurring in response to a UV light stimulus." [GOC:jl]
is_a: GO:0043478 ! pigment accumulation in response to UV light
is_a: GO:0043480 ! pigment accumulation in tissues

[Term]
id: GO:0043480
name: pigment accumulation in tissues
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in a tissue, occurring in response to an external stimulus." [GOC:jl]
synonym: "organismal pigment accumulation" EXACT []
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0043476 ! pigment accumulation

[Term]
id: GO:0043481
name: anthocyanin accumulation in tissues in response to UV light
namespace: biological_process
def: "The aggregation of the pigment anthocyanin in a particular location in a tissue, occurring in response to a UV light stimulus." [GOC:jl]
is_a: GO:0043479 ! pigment accumulation in tissues in response to UV light

[Term]
id: GO:0043482
name: cellular pigment accumulation
namespace: biological_process
def: "The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus." [GOC:jl]
subset: gosubset_prok
is_a: GO:0033059 ! cellular pigmentation
is_a: GO:0043476 ! pigment accumulation
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0043483
name: anthocyanin biosynthetic process during anthocyanin accumulation in response to UV light
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the pigment anthocyanin, occurring during anthocyanin accumulation in a tissue in response to a UV light stimulus." [GOC:jl]
synonym: "anthocyanin biosynthesis during anthocyanin accumulation in tissues in response to UV light stimulus" EXACT []
synonym: "anthocyanin biosynthetic process during anthocyanin accumulation in tissues in response to UV light stimulus" EXACT []
is_a: GO:0009718 ! anthocyanin biosynthetic process
is_a: GO:0043477 ! pigment biosynthetic process during pigment accumulation
relationship: part_of GO:0043481 ! anthocyanin accumulation in tissues in response to UV light

[Term]
id: GO:0043484
name: regulation of RNA splicing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: regulates GO:0008380 ! RNA splicing

[Term]
id: GO:0043485
name: endosome to pigment granule transport
namespace: biological_process
def: "The directed movement of substances from endosomes to pigment granules." [GOC:jl]
is_a: GO:0016197 ! endosome transport
relationship: part_of GO:0048757 ! pigment granule maturation

[Term]
id: GO:0043486
name: histone exchange
namespace: biological_process
def: "The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277]
comment: Note that this term also includes the exchange of sperm-specific histones or protamines with histones, occurring during spermatogenesis and fertilization.
synonym: "histone chaperone" RELATED [GOC:vw]
synonym: "histone displacement" EXACT []
synonym: "histone replacement" EXACT []
is_a: GO:0034728 ! nucleosome organization
is_a: GO:0043044 ! ATP-dependent chromatin remodeling

[Term]
id: GO:0043487
name: regulation of RNA stability
namespace: biological_process
def: "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl]
subset: gosubset_prok
is_a: GO:0010608 ! posttranscriptional regulation of gene expression
is_a: GO:0051252 ! regulation of RNA metabolic process

[Term]
id: GO:0043488
name: regulation of mRNA stability
namespace: biological_process
def: "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl]
subset: gosubset_prok
is_a: GO:0016071 ! mRNA metabolic process
is_a: GO:0043487 ! regulation of RNA stability

[Term]
id: GO:0043489
name: RNA stabilization
namespace: biological_process
def: "Prevention of degradation of RNA molecules." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0043487 ! regulation of RNA stability

[Term]
id: GO:0043490
name: malate-aspartate shuttle
namespace: biological_process
def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, http://cancerweb.ncl.ac.uk/]
synonym: "malate aspartate shuttle" EXACT []
synonym: "malate/aspartate shuttle" EXACT []
synonym: "malate:aspartate shuttle" EXACT []
xref: Wikipedia:Malate-aspartate_shuttle
is_a: GO:0006839 ! mitochondrial transport
relationship: part_of GO:0022904 ! respiratory electron transport chain

[Term]
id: GO:0043491
name: protein kinase B signaling cascade
namespace: biological_process
def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B, which occurs as a result of a single trigger reaction or compound." [GOC:bf]
synonym: "AKT signaling cascade" EXACT []
synonym: "AKT signalling cascade" EXACT []
synonym: "PKB signaling cascade" EXACT []
synonym: "PKB signalling cascade" EXACT []
synonym: "protein kinase B signalling cascade" EXACT []
is_a: GO:0007243 ! protein kinase cascade

[Term]
id: GO:0043492
name: ATPase activity, coupled to movement of substances
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of a substance." [GOC:jl]
subset: gosubset_prok
is_a: GO:0042623 ! ATPase activity, coupled

[Term]
id: GO:0043493
name: phage terminase complex
namespace: cellular_component
def: "A complex of a large and small subunit which catalyze the packaging of DNA into phage heads. Note that not all phage terminases have this structure, some exist as single polypeptides." [GOC:mlg]
is_a: GO:0033655 ! host cell cytoplasm part
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0043494
name: Rik1-E3 ubiquitin ligase complex
namespace: cellular_component
def: "A protein complex that consists of (minimally) cullin, RING finger, methyltransferase, Rik1 WD repeat protein, Raf1 and Raf2. Required to regulate heterochromatin formation by RNAi and for histone H3K9 methylation." [GOC:jl, PMID:16024659, PMID:16040243]
synonym: "Rik1 E3 ubiquitin ligase complex" EXACT []
is_a: GO:0031465 ! Cul4B-RING ubiquitin ligase complex

[Term]
id: GO:0043495
name: protein anchor
namespace: molecular_function
def: "Interacting selectively and non-covalently with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific location on the membrane." [GOC:go_curators]
synonym: "anchoring" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043496
name: regulation of protein homodimerization activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:jl, GOC:tb]
comment: Note that protein homodimerization is a molecular function: 'protein homodimerization activity ; GO:0042803'.
is_a: GO:0043393 ! regulation of protein binding

[Term]
id: GO:0043497
name: regulation of protein heterodimerization activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer." [GOC:jl, GOC:tb]
comment: Note that protein heterodimerization is a molecular function: 'protein heterodimerization activity ; GO:0046982'.
is_a: GO:0043393 ! regulation of protein binding

[Term]
id: GO:0043498
name: cell surface binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any component on the surface of a cell." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0043499
name: eukaryotic cell surface binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any component on the surface of a eukaryotic cell." [GOC:jl]
is_a: GO:0043498 ! cell surface binding

[Term]
id: GO:0043500
name: muscle adaptation
namespace: biological_process
def: "A process by which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]
subset: goslim_pir
synonym: "muscle plasticity" RELATED []
is_a: GO:0003012 ! muscle system process

[Term]
id: GO:0043501
name: skeletal muscle adaptation
namespace: biological_process
def: "Any process by which skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]
synonym: "skeletal muscle plasticity" RELATED []
is_a: GO:0014888 ! striated muscle adaptation

[Term]
id: GO:0043502
name: regulation of muscle adaptation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle adaptation." [GOC:go_curators, GOC:mtg_muscle]
synonym: "regulation of muscle plasticity" RELATED []
is_a: GO:0090257 ! regulation of muscle system process
relationship: regulates GO:0043500 ! muscle adaptation

[Term]
id: GO:0043503
name: skeletal muscle fiber adaptation
namespace: biological_process
def: "Any process by which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]
synonym: "skeletal muscle fiber plasticity" RELATED []
synonym: "skeletal muscle fibre plasticity" EXACT []
synonym: "skeletal myofiber plasticity" EXACT []
synonym: "skeletal myofibre plasticity" EXACT []
is_a: GO:0043501 ! skeletal muscle adaptation

[Term]
id: GO:0043504
name: mitochondrial DNA repair
namespace: biological_process
def: "The process of restoring mitochondrial DNA after damage." [PMID:12565799, PMID:15189144, PMID:16050976]
is_a: GO:0006281 ! DNA repair
is_a: GO:0032042 ! mitochondrial DNA metabolic process

[Term]
id: GO:0043505
name: centromere-specific nucleosome
namespace: cellular_component
def: "A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)." [GOC:go_curators, PMID:15175412, PMID:16183641]
synonym: "centromere specific nucleosome" EXACT []
synonym: "centromeric nucleosome" EXACT []
is_a: GO:0000786 ! nucleosome
relationship: part_of GO:0000939 ! inner kinetochore of condensed chromosome

[Term]
id: GO:0043506
name: regulation of JUN kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of JUN kinase activity." [GOC:jl]
synonym: "regulation of JUNK activity" EXACT []
is_a: GO:0001932 ! regulation of protein amino acid phosphorylation
is_a: GO:0043405 ! regulation of MAP kinase activity
is_a: GO:0046328 ! regulation of JNK cascade

[Term]
id: GO:0043507
name: positive regulation of JUN kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of JUN kinase activity." [GOC:jl]
synonym: "positive regulation of JUNK activity" EXACT []
synonym: "stimulation of JNK activity" NARROW []
synonym: "up regulation of JNK activity" EXACT []
synonym: "up-regulation of JNK activity" EXACT []
synonym: "upregulation of JNK activity" EXACT []
is_a: GO:0043406 ! positive regulation of MAP kinase activity
is_a: GO:0043506 ! regulation of JUN kinase activity

[Term]
id: GO:0043508
name: negative regulation of JUN kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of JUN kinase activity." [GOC:jl]
synonym: "down regulation of JNK activity" EXACT []
synonym: "down-regulation of JNK activity" EXACT []
synonym: "downregulation of JNK activity" EXACT []
synonym: "inhibition of JNK activity" NARROW []
synonym: "negative regulation of JUNK activity" EXACT []
is_a: GO:0043407 ! negative regulation of MAP kinase activity
is_a: GO:0043506 ! regulation of JUN kinase activity

[Term]
id: GO:0043509
name: activin A complex
namespace: cellular_component
alt_id: GO:0048181
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A)." [GOC:go_curators]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and an inhibin alpha subunit. See also the cellular component term 'inhibin complex ; GO:0043511'.
is_a: GO:0048180 ! activin complex

[Term]
id: GO:0043510
name: activin B complex
namespace: cellular_component
alt_id: GO:0048182
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B)." [GOC:go_curators]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
is_a: GO:0048180 ! activin complex

[Term]
id: GO:0043511
name: inhibin complex
namespace: cellular_component
def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B." [GOC:jl]
comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0043512
name: inhibin A complex
namespace: cellular_component
def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit." [GOC:jl]
comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
is_a: GO:0043511 ! inhibin complex

[Term]
id: GO:0043513
name: inhibin B complex
namespace: cellular_component
def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit." [GOC:jl]
comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'.
is_a: GO:0043511 ! inhibin complex

[Term]
id: GO:0043514
name: interleukin-12 complex
namespace: cellular_component
def: "A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space." [GOC:add, GOC:ebc, GOC:mah, PMID:12948519, PMID:1381512]
comment: Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain.
synonym: "IL-12 complex" EXACT [GOC:mah]
synonym: "IL12A" NARROW [GOC:add]
synonym: "IL12B" NARROW [GOC:add]
synonym: "p35" NARROW [GOC:add]
synonym: "p40" NARROW [GOC:add]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0043515
name: kinetochore binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached." [GOC:jl, http://www.mercksource.com/]
is_a: GO:0005488 ! binding

[Term]
id: GO:0043516
name: regulation of DNA damage response, signal transduction by p53 class mediator
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]
synonym: "regulation of p53 induced by DNA damage response" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator

[Term]
id: GO:0043517
name: positive regulation of DNA damage response, signal transduction by p53 class mediator
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]
synonym: "activation of DNA damage response, signal transduction by p53 class mediator" NARROW []
synonym: "positive regulation of p53 induced by DNA damage response" EXACT []
synonym: "stimulation of DNA damage response, signal transduction by p53 class mediator" NARROW []
synonym: "up regulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
synonym: "up-regulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
synonym: "upregulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator

[Term]
id: GO:0043518
name: negative regulation of DNA damage response, signal transduction by p53 class mediator
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]
synonym: "down regulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
synonym: "down-regulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
synonym: "downregulation of DNA damage response, signal transduction by p53 class mediator" EXACT []
synonym: "inhibition of DNA damage response, signal transduction by p53 class mediator" NARROW []
synonym: "negative regulation of p53 induced by DNA damage response" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator

[Term]
id: GO:0043519
name: regulation of myosin II filament assembly or disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation or disassembly of a bipolar filament composed of myosin II molecules." [GOC:jl]
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
relationship: regulates GO:0031038 ! myosin II filament assembly or disassembly

[Term]
id: GO:0043520
name: regulation of myosin II filament assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a bipolar filament composed of myosin II molecules." [GOC:jl]
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0043519 ! regulation of myosin II filament assembly or disassembly
relationship: regulates GO:0031036 ! myosin II filament assembly

[Term]
id: GO:0043521
name: regulation of myosin II filament disassembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the disassembly of a bipolar filament composed of myosin II molecules." [GOC:jl]
is_a: GO:0043244 ! regulation of protein complex disassembly
is_a: GO:0043519 ! regulation of myosin II filament assembly or disassembly
relationship: regulates GO:0031037 ! myosin II filament disassembly

[Term]
id: GO:0043522
name: leucine zipper domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns." [GOC:jl, InterPro:IPR002158]
synonym: "leucine zipper binding" EXACT []
is_a: GO:0030275 ! LRR domain binding

[Term]
id: GO:0043523
name: regulation of neuron apoptosis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptosis in neurons." [GOC:go_curators]
synonym: "regulation of apoptosis of neuronal cells" EXACT []
synonym: "regulation of apoptosis of neurons" EXACT []
synonym: "regulation of neuron programmed cell death" EXACT []
synonym: "regulation of neuronal cell programmed cell death" EXACT []
synonym: "regulation of programmed cell death of neuronal cells" EXACT []
synonym: "regulation of programmed cell death, neurons" EXACT []
is_a: GO:0042981 ! regulation of apoptosis
relationship: regulates GO:0051402 ! neuron apoptosis

[Term]
id: GO:0043524
name: negative regulation of neuron apoptosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis in neurons." [GOC:go_curators]
synonym: "down regulation of neuron apoptosis" EXACT []
synonym: "down-regulation of neuron apoptosis" EXACT []
synonym: "downregulation of neuron apoptosis" EXACT []
synonym: "inhibition of neuron apoptosis" NARROW []
synonym: "negative regulation of programmed cell death, neurons" EXACT []
synonym: "neuron survival" NARROW []
is_a: GO:0043066 ! negative regulation of apoptosis
is_a: GO:0043523 ! regulation of neuron apoptosis
relationship: negatively_regulates GO:0051402 ! neuron apoptosis

[Term]
id: GO:0043525
name: positive regulation of neuron apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptosis." [GOC:go_curators]
synonym: "activation of neuron apoptosis" NARROW []
synonym: "positive regulation of programmed cell death, neurons" EXACT []
synonym: "stimulation of neuron apoptosis" NARROW []
synonym: "up regulation of neuron apoptosis" EXACT []
synonym: "up-regulation of neuron apoptosis" EXACT []
synonym: "upregulation of neuron apoptosis" EXACT []
is_a: GO:0043065 ! positive regulation of apoptosis
is_a: GO:0043523 ! regulation of neuron apoptosis
relationship: positively_regulates GO:0051402 ! neuron apoptosis

[Term]
id: GO:0043526
name: neuroprotection
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptosis in the nervous system. It may stop or prevent or reduce the rate of cell death by apoptosis and it is activated by stress to counteract death signals in central nervous systems. Different neuroprotective mechanisms may be activated to combat distinct types of cellular stress, ERK pathway is one of several neuroprotective mechanisms and it is a model system to study neuronal apoptosis, which may contribute to several neurodegenerative diseases and aging-related neuron loss." [MeSH:G04.335.139.160, PMID:10208444, PMID:11909981, PMID:15905876]
xref: Wikipedia:Neuroprotection
is_a: GO:0043523 ! regulation of neuron apoptosis

[Term]
id: GO:0043527
name: tRNA methyltransferase complex
namespace: cellular_component
def: "A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0034708 ! methyltransferase complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0043528
name: tRNA (m2G10) methyltransferase complex
namespace: cellular_component
def: "A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p." [PMID:15899842]
is_a: GO:0043527 ! tRNA methyltransferase complex

[Term]
id: GO:0043529
name: GET complex
namespace: cellular_component
def: "A multisubunit complex involved in ER/Golgi trafficking (Golgi to ER Traffic). In yeast, includes Get1p, Get2p and Get3p proteins." [PMID:16269340]
synonym: "Golgi to ER Traffic complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0043530
name: adenosine 5'-monophosphoramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP-NH2 (adenosine 5'-monophosphoramidate) = AMP + NH2. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester." [PMID:11805111]
synonym: "adenosine 5' monophosphoramidase activity" EXACT []
synonym: "adenosine 5'-monophosphoramidate hydrolase activity" EXACT []
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0043531
name: ADP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate." [GOC:jl]
synonym: "adenosine 5'-diphosphate binding" EXACT []
synonym: "adenosine diphosphate binding" EXACT []
is_a: GO:0032559 ! adenyl ribonucleotide binding

[Term]
id: GO:0043532
name: angiostatin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis." [PMID:16043488]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043533
name: inositol 1,3,4,5 tetrakisphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with inositol 1,3,4,5 tetrakisphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "InsP4 binding" EXACT []
synonym: "IP4 binding" EXACT []
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0043534
name: blood vessel endothelial cell migration
namespace: biological_process
def: "The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis." [PMID:11166264]
is_a: GO:0043542 ! endothelial cell migration

[Term]
id: GO:0043535
name: regulation of blood vessel endothelial cell migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]
is_a: GO:0010594 ! regulation of endothelial cell migration
relationship: regulates GO:0043534 ! blood vessel endothelial cell migration

[Term]
id: GO:0043536
name: positive regulation of blood vessel endothelial cell migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]
synonym: "activation of blood vessel endothelial cell migration" NARROW []
synonym: "stimulation of blood vessel endothelial cell migration" NARROW []
synonym: "up regulation of blood vessel endothelial cell migration" EXACT []
synonym: "up-regulation of blood vessel endothelial cell migration" EXACT []
synonym: "upregulation of blood vessel endothelial cell migration" EXACT []
is_a: GO:0010595 ! positive regulation of endothelial cell migration
is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration
relationship: positively_regulates GO:0043534 ! blood vessel endothelial cell migration

[Term]
id: GO:0043537
name: negative regulation of blood vessel endothelial cell migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]
synonym: "down regulation of blood vessel endothelial cell migration" EXACT []
synonym: "down-regulation of blood vessel endothelial cell migration" EXACT []
synonym: "downregulation of blood vessel endothelial cell migration" EXACT []
synonym: "inhibition of blood vessel endothelial cell migration" NARROW []
is_a: GO:0010596 ! negative regulation of endothelial cell migration
is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration
relationship: negatively_regulates GO:0043534 ! blood vessel endothelial cell migration

[Term]
id: GO:0043538
name: regulation of actin phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule." [GOC:go_curators]
is_a: GO:0001932 ! regulation of protein amino acid phosphorylation
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
relationship: regulates GO:0031289 ! actin phosphorylation

[Term]
id: GO:0043539
name: protein serine/threonine kinase activator activity
namespace: molecular_function
def: "Increases the activity of a protein serine/threonine kinase." [GOC:go_curators]
synonym: "protein ser/thr kinase activator activity" EXACT []
is_a: GO:0030295 ! protein kinase activator activity

[Term]
id: GO:0043540
name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex
namespace: cellular_component
def: "A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis." [GOC:jl, GOC:so]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0043541
name: UDP-N-acetylglucosamine transferase complex
namespace: cellular_component
def: "A heterooligomeric complex that in yeast is composed of a catalytic subunit, Alg13p, and an anchoring subunit, Alg14p. Catalyzes the second step of dolichyl-linked oligosaccharide synthesis of GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc." [PMID:15615718, PMID:16100110, PMID:16100113]
comment: See also the molecular function term 'N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity ; GO:0004577'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane

[Term]
id: GO:0043542
name: endothelial cell migration
namespace: biological_process
def: "The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0043543
name: protein amino acid acylation
namespace: biological_process
def: "The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid." [GOC:jl]
subset: gosubset_prok
is_a: GO:0006464 ! protein modification process

[Term]
id: GO:0043544
name: lipoamide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [GOC:go_curators]
is_a: GO:0031405 ! lipoic acid binding

[Term]
id: GO:0043545
name: molybdopterin cofactor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]
subset: gosubset_prok
synonym: "Moco metabolic process" EXACT []
synonym: "Moco metabolism" EXACT []
synonym: "molybdopterin cofactor metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0042558 ! pteridine and derivative metabolic process
is_a: GO:0051189 ! prosthetic group metabolic process

[Term]
id: GO:0043546
name: molybdopterin cofactor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]
synonym: "Moco binding" EXACT []
is_a: GO:0050662 ! coenzyme binding

[Term]
id: GO:0043547
name: positive regulation of GTPase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a GTPase." [GOC:jl]
synonym: "activation of GTPase activity" NARROW []
synonym: "stimulation of GTPase activity" NARROW []
synonym: "up regulation of GTPase activity" EXACT []
synonym: "up-regulation of GTPase activity" EXACT []
synonym: "upregulation of GTPase activity" EXACT []
is_a: GO:0043087 ! regulation of GTPase activity
is_a: GO:0051345 ! positive regulation of hydrolase activity

[Term]
id: GO:0043548
name: phosphoinositide 3-kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phosphoinositide 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [PMID:10209156, PMID:9255069]
is_a: GO:0019900 ! kinase binding

[Term]
id: GO:0043549
name: regulation of kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf]
subset: gosubset_prok
is_a: GO:0042325 ! regulation of phosphorylation
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:0043550
name: regulation of lipid kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:bf]
subset: gosubset_prok
is_a: GO:0019216 ! regulation of lipid metabolic process
is_a: GO:0043549 ! regulation of kinase activity

[Term]
id: GO:0043551
name: regulation of phosphoinositide 3-kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphoinositide 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring." [GOC:bf]
is_a: GO:0043550 ! regulation of lipid kinase activity

[Term]
id: GO:0043552
name: positive regulation of phosphoinositide 3-kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphoinositide 3-kinase activity." [GOC:bf]
synonym: "activation of phosphoinositide 3-kinase activity" NARROW []
synonym: "stimulation of phosphoinositide 3-kinase activity" NARROW []
synonym: "up regulation of phosphoinositide 3-kinase activity" EXACT []
synonym: "up-regulation of phosphoinositide 3-kinase activity" EXACT []
synonym: "upregulation of phosphoinositide 3-kinase activity" EXACT []
is_a: GO:0043551 ! regulation of phosphoinositide 3-kinase activity
is_a: GO:0090218 ! positive regulation of lipid kinase activity

[Term]
id: GO:0043553
name: negative regulation of phosphoinositide 3-kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphoinositide 3-kinase activity." [GOC:bf]
synonym: "down regulation of phosphoinositide 3-kinase activity" EXACT []
synonym: "down-regulation of phosphoinositide 3-kinase activity" EXACT []
synonym: "downregulation of phosphoinositide 3-kinase activity" EXACT []
synonym: "inhibition of phosphoinositide 3-kinase activity" NARROW []
is_a: GO:0043551 ! regulation of phosphoinositide 3-kinase activity
is_a: GO:0090219 ! negative regulation of lipid kinase activity

[Term]
id: GO:0043554
name: aerobic respiration, using arsenite as electron donor
namespace: biological_process
def: "The oxidation of arsenite to arsenate, using oxygen (O2) as the electron acceptor. Arsenite oxidase provides electrons to an electron carrier which transfers them to oxygen utilizing respiratory systems." [GOC:mlg]
is_a: GO:0009060 ! aerobic respiration
is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds

[Term]
id: GO:0043555
name: regulation of translation in response to stress
namespace: biological_process
def: "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl]
synonym: "translational stress response" EXACT []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0043556
name: regulation of translation in response to oxidative stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl]
is_a: GO:0034599 ! cellular response to oxidative stress
is_a: GO:0043555 ! regulation of translation in response to stress

[Term]
id: GO:0043557
name: regulation of translation in response to osmotic stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl]
is_a: GO:0006970 ! response to osmotic stress
is_a: GO:0043555 ! regulation of translation in response to stress

[Term]
id: GO:0043558
name: regulation of translational initiation in response to stress
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress." [GOC:jl]
synonym: "regulation of translation initiation in response to stress" EXACT [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0043555 ! regulation of translation in response to stress

[Term]
id: GO:0043559
name: insulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0043560
name: insulin receptor substrate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex." [PMID:12829233]
synonym: "insulin receptor substrate [protein] binding" EXACT []
synonym: "IRS [protein] binding" EXACT []
synonym: "IRS binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043561
name: regulation of translational initiation in response to osmotic stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, GOC:jl, GOC:tb]
is_a: GO:0043557 ! regulation of translation in response to osmotic stress
is_a: GO:0043558 ! regulation of translational initiation in response to stress

[Term]
id: GO:0043562
name: cellular response to nitrogen levels
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen." [GOC:jl]
subset: gosubset_prok
is_a: GO:0031669 ! cellular response to nutrient levels

[Term]
id: GO:0043563
name: odorant transporter activity
namespace: molecular_function
def: "Enables the directed movement of odorants, any substance capable of stimulating the sense of smell, into, out of, within or between cells." [GOC:jl]
subset: gosubset_prok
is_a: GO:0005215 ! transporter activity

[Term]
id: GO:0043564
name: Ku70:Ku80 complex
namespace: cellular_component
def: "Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983]
synonym: "Ku70:Ku80 heterodimer" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0043565
name: sequence-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]
subset: gosubset_prok
synonym: "sequence specific DNA binding" EXACT []
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0043566
name: structure-specific DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding." [GOC:jl]
subset: gosubset_prok
synonym: "structure specific DNA binding" EXACT []
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0043567
name: regulation of insulin-like growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf]
synonym: "regulation of IGF receptor signaling pathway" EXACT []
synonym: "regulation of IGF receptor signalling pathway" EXACT []
synonym: "regulation of insulin-like growth factor receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway

[Term]
id: GO:0043568
name: positive regulation of insulin-like growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf]
synonym: "activation of insulin-like growth factor receptor signaling pathway" NARROW []
synonym: "positive regulation of IGF receptor signaling pathway" EXACT []
synonym: "positive regulation of IGF receptor signalling pathway" EXACT []
synonym: "positive regulation of insulin-like growth factor receptor signalling pathway" EXACT []
synonym: "stimulation of insulin-like growth factor receptor signaling pathway" NARROW []
synonym: "up regulation of insulin-like growth factor receptor signaling pathway" EXACT []
synonym: "up-regulation of insulin-like growth factor receptor signaling pathway" EXACT []
synonym: "upregulation of insulin-like growth factor receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0043567 ! regulation of insulin-like growth factor receptor signaling pathway
relationship: positively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway

[Term]
id: GO:0043569
name: negative regulation of insulin-like growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf]
synonym: "down regulation of insulin-like growth factor receptor signaling pathway" EXACT []
synonym: "down-regulation of insulin-like growth factor receptor signaling pathway" EXACT []
synonym: "downregulation of insulin-like growth factor receptor signaling pathway" EXACT []
synonym: "inhibition of insulin-like growth factor receptor signaling pathway" NARROW []
synonym: "negative regulation of IGF receptor signaling pathway" EXACT []
synonym: "negative regulation of IGF receptor signalling pathway" EXACT []
synonym: "negative regulation of insulin-like growth factor receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0043567 ! regulation of insulin-like growth factor receptor signaling pathway
relationship: negatively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway

[Term]
id: GO:0043570
name: maintenance of DNA repeat elements
namespace: biological_process
def: "Any process involved in sustaining the fidelity and copy number of DNA repeat elements." [GOC:jl]
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0043571
name: maintenance of CRISPR repeat elements
namespace: biological_process
def: "Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences." [PMID:16292354]
synonym: "CRISPR element metabolic process" RELATED []
synonym: "CRISPR element metabolism" RELATED []
synonym: "maintenance of clustered regularly interspaced short palindromic repeat elements" EXACT []
is_a: GO:0043570 ! maintenance of DNA repeat elements

[Term]
id: GO:0043572
name: plastid fission
namespace: biological_process
def: "The creation of two or more plastids by division of one plastid. A plastid is any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA." [GOC:jl]
is_a: GO:0048285 ! organelle fission

[Term]
id: GO:0043573
name: leucoplast fission
namespace: biological_process
def: "The creation of two or more leucoplasts by division of one leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jl]
is_a: GO:0043572 ! plastid fission

[Term]
id: GO:0043574
name: peroxisomal transport
namespace: biological_process
def: "Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:jl]
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0043575
name: detection of osmotic stimulus
namespace: biological_process
def: "The series of events in which a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell is received and converted into a molecular signal." [GOC:jl]
is_a: GO:0006970 ! response to osmotic stress
is_a: GO:0009582 ! detection of abiotic stimulus

[Term]
id: GO:0043576
name: regulation of respiratory gaseous exchange
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment." [GOC:jl]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0007585 ! respiratory gaseous exchange

[Term]
id: GO:0043577
name: chemotropism
namespace: biological_process
def: "The movement of an organism, or part of an organism, in response to an external chemical gradient, usually toward or away from it." [GOC:jl, http://cancerweb.ncl.ac.uk/]
xref: Wikipedia:Chemotropism
is_a: GO:0009606 ! tropism
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0043578
name: nuclear matrix organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane." [GOC:dph, GOC:jl, GOC:mah]
synonym: "nuclear matrix organisation" EXACT [GOC:curators]
synonym: "nuclear matrix organization and biogenesis" RELATED [GOC:mah]
synonym: "nucleoskeleton organization" EXACT [GOC:tb]
is_a: GO:0006997 ! nucleus organization

[Term]
id: GO:0043579
name: elaioplast organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an elaioplast, a leucoplast in which oil is stored." [GOC:jl]
synonym: "elaioplast organisation" EXACT [GOC:curators]
synonym: "elaioplast organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0009657 ! plastid organization

[Term]
id: GO:0043580
name: periplasmic space organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi." [GOC:dph, GOC:jl, GOC:mah]
subset: gosubset_prok
synonym: "periplasmic space organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0009987 ! cellular process
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0043581
name: mycelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mycelium over time, from its formation to the mature structure. A mycelium is the mass of hyphae that constitutes the vegetative part of a fungus." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0043582
name: sporangium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sporangium over time, from its formation to the mature structure. A sporangium is a structure producing and containing spores." [GOC:jl, Wikipedia:Sporagium]
synonym: "sporangia development" EXACT []
is_a: GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0043583
name: ear development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023]
synonym: "hearing organ development" EXACT []
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0043584
name: nose development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl, http://www.mercksource.com/]
synonym: "nasus development" EXACT []
is_a: GO:0007423 ! sensory organ development
relationship: part_of GO:0060541 ! respiratory system development

[Term]
id: GO:0043585
name: nose morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the nose are generated and organized. Morphogenesis pertains to the creation of form. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl, http://www.mercksource.com/]
synonym: "nasus morphogenesis" EXACT []
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0043584 ! nose development

[Term]
id: GO:0043586
name: tongue development
namespace: biological_process
def: "The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, http://cancerweb.ncl.ac.uk/, http://www.mercksource.com/]
synonym: "glossa development" NARROW []
synonym: "lingua development" NARROW []
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0043587
name: tongue morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the tongue are generated and organized. Morphogenesis pertains to the creation of form. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, http://cancerweb.ncl.ac.uk/, http://www.mercksource.com/]
synonym: "glossa morphogenesis" NARROW []
synonym: "lingua morphogenesis" EXACT []
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0043586 ! tongue development

[Term]
id: GO:0043588
name: skin development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, http://cancerweb.ncl.ac.uk/]
synonym: "animal skin development" EXACT []
is_a: GO:0008544 ! epidermis development

[Term]
id: GO:0043589
name: skin morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the skin are generated and organized. Morphogenesis pertains to the creation of form. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, http://cancerweb.ncl.ac.uk/]
is_a: GO:0048730 ! epidermis morphogenesis
relationship: part_of GO:0043588 ! skin development

[Term]
id: GO:0043590
name: bacterial nucleoid
namespace: cellular_component
def: "The region of a bacterial cell to which the DNA is confined." [GOC:jl]
subset: gosubset_prok
is_a: GO:0009295 ! nucleoid

[Term]
id: GO:0043591
name: endospore external encapsulating structure
namespace: cellular_component
alt_id: GO:0055030
def: "The structures that lie outside the inner membrane and surround the entire endospore; consists of a peptidoglycan-containing inner layer (the endospore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer." [GOC:go_curators, PMID:15035041]
subset: goslim_pir
synonym: "endospore wall" EXACT [GOC:mah]
synonym: "peptidoglycan-based spore wall" EXACT [GOC:mtg_sensu]
synonym: "spore wall" BROAD [GOC:mtg_sensu]
is_a: GO:0031160 ! spore wall

[Term]
id: GO:0043592
name: exosporium
namespace: cellular_component
def: "The outermost layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid." [GOC:mlg]
subset: gosubset_prok
synonym: "epispore" RELATED []
synonym: "exospore" RELATED []
synonym: "perispore" RELATED []
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0043591 ! endospore external encapsulating structure

[Term]
id: GO:0043593
name: endospore coat
namespace: cellular_component
def: "The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0043591 ! endospore external encapsulating structure

[Term]
id: GO:0043594
name: outer endospore membrane
namespace: cellular_component
def: "The outer membrane around a bacterial endospore, located between the endospore cortex and endospore coat." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0019867 ! outer membrane
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0043591 ! endospore external encapsulating structure

[Term]
id: GO:0043595
name: endospore cortex
namespace: cellular_component
def: "A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan." [GOC:mlg]
subset: gosubset_prok
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0043591 ! endospore external encapsulating structure

[Term]
id: GO:0043596
name: nuclear replication fork
namespace: cellular_component
def: "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0005657 ! replication fork
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0043597
name: cytoplasmic replication fork
namespace: cellular_component
def: "The Y-shaped region of a cytoplasmic replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0005657 ! replication fork
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0000229 ! cytoplasmic chromosome

[Term]
id: GO:0043598
name: cytoplasmic DNA replication factor C complex
namespace: cellular_component
def: "A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. Examples of this component are found in prokaryotic species." [GOC:mtg_sensu, PMID:14646196, PMID:16172520]
is_a: GO:0005663 ! DNA replication factor C complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0043600 ! cytoplasmic replisome

[Term]
id: GO:0043599
name: nuclear DNA replication factor C complex
namespace: cellular_component
def: "A nuclear complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species." [GOC:mtg_sensu, PMID:14614842]
is_a: GO:0005663 ! DNA replication factor C complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043601 ! nuclear replisome

[Term]
id: GO:0043600
name: cytoplasmic replisome
namespace: cellular_component
def: "A multi-component enzymatic machine at the cytoplasmic replication fork, which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0030894 ! replisome
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0043597 ! cytoplasmic replication fork

[Term]
id: GO:0043601
name: nuclear replisome
namespace: cellular_component
def: "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu]
is_a: GO:0030894 ! replisome
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043596 ! nuclear replication fork

[Term]
id: GO:0043602
name: nitrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid." [GOC:jl]
synonym: "nitrate disassimilation" EXACT []
synonym: "nitrate dissimilation" EXACT []
is_a: GO:0042126 ! nitrate metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process

[Term]
id: GO:0043603
name: cellular amide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [ChEBI:32988]
subset: goslim_pir
subset: gosubset_prok
synonym: "amide metabolism" EXACT []
is_a: GO:0034641 ! cellular nitrogen compound metabolic process

[Term]
id: GO:0043604
name: amide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [ChEBI:32988]
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process

[Term]
id: GO:0043605
name: cellular amide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [ChEBI:32988]
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process

[Term]
id: GO:0043606
name: formamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/]
synonym: "formamide metabolism" EXACT []
is_a: GO:0043603 ! cellular amide metabolic process

[Term]
id: GO:0043607
name: formamide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/]
is_a: GO:0043604 ! amide biosynthetic process
is_a: GO:0043606 ! formamide metabolic process

[Term]
id: GO:0043608
name: formamide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/]
is_a: GO:0043605 ! cellular amide catabolic process
is_a: GO:0043606 ! formamide metabolic process

[Term]
id: GO:0043609
name: regulation of carbon utilization
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of carbon utilization." [GOC:jl]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0015976 ! carbon utilization

[Term]
id: GO:0043610
name: regulation of carbohydrate utilization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of carbohydrate utilization." [GOC:jl]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0009758 ! carbohydrate utilization

[Term]
id: GO:0043611
name: isoprene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isoprene, C5H8." [GOC:jl]
subset: gosubset_prok
synonym: "2-methyl-1,3-butadiene metabolic process" EXACT []
synonym: "2-methyl-1,3-butadiene metabolism" EXACT []
synonym: "hemiterpene metabolic process" EXACT []
synonym: "hemiterpene metabolism" EXACT []
synonym: "isoprene metabolism" EXACT []
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:0043612
name: isoprene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isoprene, C5H8." [GOC:jl]
synonym: "2-methyl-1,3-butadiene biosynthesis" EXACT []
synonym: "2-methyl-1,3-butadiene biosynthetic process" EXACT []
synonym: "hemiterpene biosynthesis" EXACT []
synonym: "hemiterpene biosynthetic process" EXACT []
is_a: GO:0008299 ! isoprenoid biosynthetic process
is_a: GO:0043611 ! isoprene metabolic process

[Term]
id: GO:0043613
name: isoprene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isoprene, C5H8." [GOC:jl]
synonym: "2-methyl-1,3-butadiene catabolic process" EXACT []
synonym: "2-methyl-1,3-butadiene catabolism" EXACT []
synonym: "hemiterpene catabolic process" EXACT []
synonym: "hemiterpene catabolism" EXACT []
is_a: GO:0043611 ! isoprene metabolic process
is_a: GO:0046247 ! terpene catabolic process

[Term]
id: GO:0043614
name: multi-eIF complex
namespace: cellular_component
def: "A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5." [GOC:krc]
synonym: "multifactor translation initiation factor (eIF) complex" EXACT []
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0043615
name: astrocyte cell migration
namespace: biological_process
def: "The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord." [CL:0000127, GOC:go_curators]
synonym: "astrocyte migration" EXACT []
synonym: "astrocytic glial cell migration" EXACT []
is_a: GO:0008347 ! glial cell migration

[Term]
id: GO:0043616
name: keratinocyte proliferation
namespace: biological_process
def: "The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin." [CL:0000311]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0043617
name: cellular response to sucrose starvation
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose." [GOC:jl]
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0043618
name: regulation of transcription from RNA polymerase II promoter in response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0043620 ! regulation of transcription in response to stress

[Term]
id: GO:0043619
name: regulation of transcription from RNA polymerase II promoter in response to oxidative stress
namespace: biological_process
def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl]
is_a: GO:0034599 ! cellular response to oxidative stress
is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress

[Term]
id: GO:0043620
name: regulation of transcription in response to stress
namespace: biological_process
def: "Modulation of the frequency, rate or extent of transcription as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0045449 ! regulation of transcription

[Term]
id: GO:0043621
name: protein self-association
namespace: molecular_function
def: "Interacting selectively and non-covalently with a domain within the same polypeptide." [GOC:jl]
synonym: "intramolecular protein binding" EXACT []
synonym: "protein self association" EXACT []
synonym: "protein self binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0043622
name: cortical microtubule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell." [GOC:curators, GOC:dph, GOC:jl, GOC:mah]
synonym: "cortical microtubule cytoskeleton organization" EXACT []
synonym: "cortical microtubule organisation" EXACT [GOC:curators]
synonym: "cortical microtubule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030865 ! cortical cytoskeleton organization
is_a: GO:0031122 ! cytoplasmic microtubule organization

[Term]
id: GO:0043623
name: cellular protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell." [GOC:jl]
subset: gosubset_prok
is_a: GO:0006461 ! protein complex assembly
is_a: GO:0034622 ! cellular macromolecular complex assembly

[Term]
id: GO:0043624
name: cellular protein complex disassembly
namespace: biological_process
def: "The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups." [GOC:jl]
subset: gosubset_prok
is_a: GO:0034623 ! cellular macromolecular complex disassembly
is_a: GO:0043241 ! protein complex disassembly

[Term]
id: GO:0043625
name: delta DNA polymerase complex
namespace: cellular_component
alt_id: GO:0005659
def: "A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614]
synonym: "delta-DNA polymerase complex" EXACT []
is_a: GO:0042575 ! DNA polymerase complex
is_a: GO:0044454 ! nuclear chromosome part
relationship: part_of GO:0043601 ! nuclear replisome

[Term]
id: GO:0043626
name: PCNA complex
namespace: cellular_component
def: "A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation." [GOC:jl, PMID:12829735]
subset: gosubset_prok
synonym: "PCNA homotrimer" EXACT []
synonym: "proliferating cell nuclear antigen complex" EXACT []
synonym: "sliding clamp" BROAD []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0043627
name: response to estrogen stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "response to oestrogen stimulus" EXACT []
is_a: GO:0048545 ! response to steroid hormone stimulus

[Term]
id: GO:0043628
name: ncRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a non-coding RNA molecule." [GOC:jl]
synonym: "ncRNA 3' end processing" EXACT []
is_a: GO:0031123 ! RNA 3'-end processing
is_a: GO:0034470 ! ncRNA processing

[Term]
id: GO:0043629
name: ncRNA polyadenylation
namespace: biological_process
def: "The enzymatic addition of a sequence of adenylyl residues at the 3' end of a non-coding RNA (ncRNA) molecule. In eukaryotes, substrates include nuclear non-coding RNAs such as precursors and a variety of incorrectly processed forms of snRNAs, snoRNAs, rRNAs, and tRNAs, as well as discarded RNA fragments which have been removed from ncRNA primary transcripts. Polyadenylation of precursors is often linked to termination of transcription, but polyadenylation of RNAs targeted for degradation may also occur post-transcriptionally. This polyadenylation is important both for 3'-end processing to produce mature ncRNA species and also for targeting incorrectly processed or discarded RNA molecules for degradation." [GOC:kf, GOC:krc, GOC:rn, PMID:15828860, PMID:15935758, PMID:16374505, PMID:16431988, PMID:18951092]
synonym: "non-coding RNA polyadenylation" EXACT []
is_a: GO:0043628 ! ncRNA 3'-end processing
is_a: GO:0043631 ! RNA polyadenylation

[Term]
id: GO:0043630
name: ncRNA polyadenylation during polyadenylation-dependent ncRNA catabolic process
namespace: biological_process
def: "The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a non-coding RNA, occurring during the process of polyadenylation-dependent non-coding RNA catabolism." [GOC:jl]
is_a: GO:0043629 ! ncRNA polyadenylation
relationship: part_of GO:0043634 ! polyadenylation-dependent ncRNA catabolic process

[Term]
id: GO:0043631
name: RNA polyadenylation
namespace: biological_process
def: "The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule." [GOC:jl]
subset: gosubset_prok
is_a: GO:0031123 ! RNA 3'-end processing

[Term]
id: GO:0043632
name: modification-dependent macromolecule catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044265 ! cellular macromolecule catabolic process

[Term]
id: GO:0043633
name: polyadenylation-dependent RNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA." [GOC:df, GOC:jl, GOC:krc]
is_a: GO:0006401 ! RNA catabolic process
is_a: GO:0043632 ! modification-dependent macromolecule catabolic process

[Term]
id: GO:0043634
name: polyadenylation-dependent ncRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA." [GOC:jl, GOC:kf, GOC:krc]
is_a: GO:0043633 ! polyadenylation-dependent RNA catabolic process

[Term]
id: GO:0043635
name: methylnaphthalene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylnaphthalene, an organic compound, C10H7CH3, obtained from coal tar." [GOC:jl, PMID:16535687]
synonym: "1-methylnaphthalene catabolic process" NARROW []
synonym: "1-methylnaphthalene catabolism" NARROW []
synonym: "1-MN catabolic process" RELATED []
synonym: "1-MN catabolism" RELATED []
synonym: "2-methylnaphthalene catabolic process" NARROW []
synonym: "2-methylnaphthalene catabolism" NARROW []
synonym: "2-MN catabolic process" RELATED []
synonym: "2-MN catabolism" RELATED []
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0043636
name: bisphenol A catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of bisphenol A, 4,4'-(propane-2,2-diyl)diphenol, a synthetic, aromatic organic compound used as a monomer in the manufacture of polycarbonate plastic and in the manufacture of epoxy resins." [ChEBI:33216, GOC:jl, Wikipedia:Bisphenol_A]
synonym: "bisphenol-A catabolic process" EXACT []
synonym: "bisphenol-A catabolism" EXACT []
is_a: GO:0019336 ! phenol catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0043637
name: puromycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving puromycin, 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [ChEBI:17939, GOC:jl, PMID:8226694, Wikipedia:Puromycin]
subset: gosubset_prok
synonym: "puromycin metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0043638
name: puromycin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [ChEBI:17939, GOC:jl, Wikipedia:Puromycin]
subset: gosubset_prok
is_a: GO:0009163 ! nucleoside biosynthetic process
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0043637 ! puromycin metabolic process

[Term]
id: GO:0043639
name: benzoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [GOC:jl]
subset: gosubset_prok
synonym: "benzoate breakdown" EXACT []
synonym: "benzoate catabolism" EXACT []
synonym: "benzoate degradation" EXACT []
is_a: GO:0018874 ! benzoate metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0043640
name: benzoate catabolic process via hydroxylation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol." [GOC:jl, MetaCyc:PWY-2503]
synonym: "benzoate breakdown via hydroxylation" EXACT []
synonym: "benzoate degradation via hydroxylation" EXACT []
xref: MetaCyc:PWY-2503
is_a: GO:0043639 ! benzoate catabolic process

[Term]
id: GO:0043641
name: novobiocin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [GOC:jl, http://cancerweb.ncl.ac.uk/, Wikipedia:Novobiocin]
subset: gosubset_prok
synonym: "novobiocin metabolism" EXACT []
is_a: GO:0009804 ! coumarin metabolic process
is_a: GO:0016137 ! glycoside metabolic process
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0043603 ! cellular amide metabolic process

[Term]
id: GO:0043642
name: novobiocin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [GOC:jl, http://cancerweb.ncl.ac.uk/, Wikipedia:Novobiocin]
subset: gosubset_prok
is_a: GO:0009805 ! coumarin biosynthetic process
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0043641 ! novobiocin metabolic process

[Term]
id: GO:0043643
name: tetracycline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [ChEBI:27902, GOC:jl, Wikipedia:Tetracycline]
subset: gosubset_prok
synonym: "tetracyclin metabolic process" EXACT []
synonym: "tetracyclin metabolism" EXACT []
synonym: "tetracycline metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0030638 ! polyketide metabolic process

[Term]
id: GO:0043644
name: tetracycline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [ChEBI:27902, GOC:jl, Wikipedia:Tetracycline]
subset: gosubset_prok
synonym: "tetracyclin biosynthesis" EXACT []
synonym: "tetracyclin biosynthetic process" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0043643 ! tetracycline metabolic process

[Term]
id: GO:0043645
name: cephalosporin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [GOC:jl, http://cancerweb.ncl.ac.uk/, Wikipedia:Cephalosporin]
subset: gosubset_prok
synonym: "cephalosporin metabolism" EXACT []
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0030653 ! beta-lactam antibiotic metabolic process

[Term]
id: GO:0043646
name: cephalosporin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [GOC:jl, http://cancerweb.ncl.ac.uk/, Wikipedia:Cephalosporin]
subset: gosubset_prok
is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process
is_a: GO:0043645 ! cephalosporin metabolic process

[Term]
id: GO:0043647
name: inositol phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [ChEBI:24848, GOC:jl]
synonym: "inositol phosphate metabolism" EXACT []
synonym: "myo-inositol phosphate metabolic process" NARROW []
synonym: "myo-inositol phosphate metabolism" NARROW []
is_a: GO:0006020 ! inositol metabolic process

[Term]
id: GO:0043648
name: dicarboxylic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dicarboxylate metabolic process" EXACT []
synonym: "dicarboxylate metabolism" EXACT []
synonym: "dicarboxylic acid metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0043649
name: dicarboxylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dicarboxylate catabolic process" EXACT []
synonym: "dicarboxylate catabolism" EXACT []
synonym: "dicarboxylic acid breakdown" EXACT []
synonym: "dicarboxylic acid catabolism" EXACT []
synonym: "dicarboxylic acid degradation" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0043650
name: dicarboxylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dicarboxylate biosynthesis" EXACT []
synonym: "dicarboxylate biosynthetic process" EXACT []
synonym: "dicarboxylic acid anabolism" EXACT []
synonym: "dicarboxylic acid biosynthesis" EXACT []
synonym: "dicarboxylic acid formation" EXACT []
synonym: "dicarboxylic acid synthesis" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0043651
name: linoleic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2." [Wikipedia:Linoleic_Acid]
synonym: "linoleic acid metabolism" EXACT []
xref: Wikipedia:Linoleic_acid
is_a: GO:0001676 ! long-chain fatty acid metabolic process
is_a: GO:0033559 ! unsaturated fatty acid metabolic process

[Term]
id: GO:0043652
name: engulfment of apoptotic cell
namespace: biological_process
def: "The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]
synonym: "engulfment of apoptotic cell corpse" EXACT []
synonym: "engulfment of cell corpse" EXACT []
is_a: GO:0006911 ! phagocytosis, engulfment
relationship: part_of GO:0043277 ! apoptotic cell clearance

[Term]
id: GO:0043653
name: mitochondrial fragmentation during apoptosis
namespace: biological_process
def: "The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form." [GOC:rk, PMID:12867994]
synonym: "mitochondrial fission during apoptosis" EXACT []
is_a: GO:0008637 ! apoptotic mitochondrial changes

[Term]
id: GO:0043654
name: recognition of apoptotic cell
namespace: biological_process
def: "The process by which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis." [GOC:rk, PMID:15536015]
synonym: "detection of apoptotic cell" EXACT []
synonym: "detection of apoptotic cell corpse" EXACT []
synonym: "detection of cell corpse" EXACT []
synonym: "recognition of apoptotic cell corpse" EXACT []
synonym: "recognition of cell corpse" EXACT []
is_a: GO:0006910 ! phagocytosis, recognition
relationship: part_of GO:0043277 ! apoptotic cell clearance

[Term]
id: GO:0043655
name: extracellular space of host
namespace: cellular_component
def: "The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream." [GOC:cc]
subset: gosubset_prok
synonym: "host extracellular space" EXACT []
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0018995 ! host

[Term]
id: GO:0043656
name: intracellular region of host
namespace: cellular_component
def: "That space within the plasma membrane of a host cell." [GOC:cc]
subset: gosubset_prok
synonym: "host intracellular" EXACT []
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0043657
name: host cell
namespace: cellular_component
def: "A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044216 ! other organism cell
relationship: part_of GO:0018995 ! host

[Term]
id: GO:0043658
name: host symbiosome
namespace: cellular_component
def: "A double-enveloped cell compartment, composed of the endosymbiont with its plasmalemma (as inner envelope) and an outer envelope (the perisymbiontic membrane) derived from the host cell." [GOC:cc]
subset: gosubset_prok
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0043659
name: symbiosome
namespace: cellular_component
def: "A double-enveloped cell compartment, composed of an endosymbiont with its plasmalemma (as inner envelope) and a non-endosymbiotic outer envelope (the perisymbiontic membrane)." [GOC:cc]
subset: gosubset_prok
is_a: GO:0030139 ! endocytic vesicle

[Term]
id: GO:0043660
name: bacteroid-containing symbiosome
namespace: cellular_component
def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants." [GOC:cc]
subset: gosubset_prok
is_a: GO:0043659 ! symbiosome

[Term]
id: GO:0043661
name: peribacteroid membrane
namespace: cellular_component
def: "A membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc]
subset: gosubset_prok
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0043660 ! bacteroid-containing symbiosome

[Term]
id: GO:0043662
name: peribacteroid fluid
namespace: cellular_component
def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0043660 ! bacteroid-containing symbiosome

[Term]
id: GO:0043663
name: host bacteroid-containing symbiosome
namespace: cellular_component
def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants, of a host cell." [GOC:cc]
subset: gosubset_prok
is_a: GO:0043658 ! host symbiosome

[Term]
id: GO:0043664
name: host peribacteroid membrane
namespace: cellular_component
def: "A host-derived membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc]
subset: gosubset_prok
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0043663 ! host bacteroid-containing symbiosome

[Term]
id: GO:0043665
name: host peribacteroid fluid
namespace: cellular_component
def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome of a host cell." [GOC:cc]
subset: gosubset_prok
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0043663 ! host bacteroid-containing symbiosome

[Term]
id: GO:0043666
name: regulation of phosphoprotein phosphatase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]
is_a: GO:0010921 ! regulation of phosphatase activity

[Term]
id: GO:0043667
name: pollen wall
namespace: cellular_component
def: "The complex wall surrounding a pollen grain." [GOC:fz]
comment: Note that this term is a child of 'extracellular matrix part ; GO:0044420' rather than the more specific middle lamella-containing extracellular matrix ; GO:0048196', because unlike the usual plant cell wall, the pollen wall does not contain a middle lamella, as specified in the definition of 'middle lamella-containing extracellular matrix ; GO:0048196'.
synonym: "microspore wall" EXACT []
is_a: GO:0044420 ! extracellular matrix part

[Term]
id: GO:0043668
name: exine
namespace: cellular_component
def: "The outer layer of the pollen grain wall which is composed primarily of sporopollenin." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that the exine is highly resistant to strong acids and bases.
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043667 ! pollen wall

[Term]
id: GO:0043669
name: ectexine
namespace: cellular_component
def: "The outer part of the exine, which stains positively with basic fuchsin in optical microscopy and has higher electron density in conventionally prepared TEM sections." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that ectexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'endexine ; GO:0043671'.
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043668 ! exine

[Term]
id: GO:0043670
name: foot layer
namespace: cellular_component
def: "The inner layer of the ectexine." [http://www.mobot.org/MOBOT/research/APweb/]
synonym: "nexine 1" EXACT []
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043669 ! ectexine

[Term]
id: GO:0043671
name: endexine
namespace: cellular_component
def: "The inner part of the exine, which stains." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that endexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'ectexine ; GO:0043669'.
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043668 ! exine

[Term]
id: GO:0043672
name: nexine
namespace: cellular_component
def: "The inner, non-sculptured part of the exine which lies below the sexine." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that nexine is distinguished on purely morphological criteria; compare with 'endexine ; GO:0043671'. See also 'sexine ; GO:0043673'.
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043668 ! exine

[Term]
id: GO:0043673
name: sexine
namespace: cellular_component
def: "The outer, sculptured layer of the exine, which lies above the nexine." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that the sexine sometimes consists of 5 layers, but of those, 3 layers are the most common (sexine 1 = columellae; sexine 2 = tectum; sexine 3 = sculpture elements). Sexine is distinguished on purely morphological criteria; compare with 'ectexine ; GO:0043669'. See also 'nexine ; GO:0043672'.
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043668 ! exine

[Term]
id: GO:0043674
name: columella
namespace: cellular_component
def: "A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella)." [http://www.mobot.org/MOBOT/research/APweb/]
synonym: "sexine 1" EXACT []
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043673 ! sexine

[Term]
id: GO:0043675
name: sculpture element
namespace: cellular_component
def: "The third layer of the sexine." [http://www.mobot.org/MOBOT/research/APweb/]
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043673 ! sexine

[Term]
id: GO:0043676
name: tectum
namespace: cellular_component
def: "The layer of sexine which forms a roof over the columella, granules or other infratectal elements." [http://www.mobot.org/MOBOT/research/APweb/]
synonym: "sexine 2" EXACT []
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043673 ! sexine

[Term]
id: GO:0043677
name: germination pore
namespace: cellular_component
def: "A small pore in the outer wall of a mycelial spore through which the germ tube exits upon germination. It can be apical or eccentric in its location." [Wikipedia:Germ_pore]
synonym: "germ pore" EXACT []
xref: Wikipedia:Germ_pore
is_a: GO:0044420 ! extracellular matrix part

[Term]
id: GO:0043678
name: intine
namespace: cellular_component
def: "The innermost of the major layers of the pollen grain wall which underlies the exine and borders the cytoplasm." [http://www.mobot.org/MOBOT/research/APweb/]
comment: Note that the intine is not acetolysis resistant and is therefore absent in conventionally prepared palynological material.
is_a: GO:0044420 ! extracellular matrix part
relationship: part_of GO:0043667 ! pollen wall

[Term]
id: GO:0043679
name: axon terminus
namespace: cellular_component
def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:jl]
synonym: "axon terminal" EXACT []
synonym: "axon terminal specialization" RELATED []
synonym: "nerve ending" EXACT []
is_a: GO:0033267 ! axon part
is_a: GO:0044306 ! neuron projection terminus

[Term]
id: GO:0043680
name: filiform apparatus
namespace: cellular_component
def: "A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells." [ISBN:0471245208]
is_a: GO:0044426 ! cell wall part

[Term]
id: GO:0043682
name: copper-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+ = ADP + phosphate + Cu2+, directly driving the transport of the copper ions across a membrane." [GOC:jl]
subset: gosubset_prok
xref: MetaCyc:3.6.3.4-RXN
is_a: GO:0005375 ! copper ion transmembrane transporter activity
is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

[Term]
id: GO:0043683
name: type IV pilus biogenesis
namespace: biological_process
def: "The cellular process by which a type IV pilus is synthesized, aggregates, and bonds together. A type IV pilus is composed of a pilus fiber and approximately ten proteins at its base; type IV pili play a role in cell motility, adherence to substrates, and aggregation." [GOC:jl, GOC:ml]
synonym: "TFP biogenesis" EXACT []
synonym: "type 4 pilus biogenesis" EXACT []
synonym: "type IV fimbria assembly" EXACT []
synonym: "type IV fimbria biogenesis" EXACT []
synonym: "type IV fimbriae assembly" EXACT []
synonym: "type IV fimbriae biogenesis" EXACT []
synonym: "type IV fimbrial assembly" EXACT []
synonym: "type IV fimbrial biogenesis" EXACT []
synonym: "type IV fimbrium assembly" EXACT []
synonym: "type IV fimbrium biogenesis" EXACT []
synonym: "type IV pilus biosynthesis" EXACT []
is_a: GO:0009297 ! pilus assembly
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0043684
name: type IV secretion system complex
namespace: cellular_component
def: "A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s)." [GOC:ml]
subset: gosubset_prok
synonym: "T4SS complex" EXACT []
synonym: "type IV protein secretion system complex" NARROW []
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0043685
name: conversion of glutamyl-tRNA to glutaminyl-tRNA
namespace: biological_process
def: "Process whereby glutamate charged on a tRNA(Gln) is converted to glutaminyl-tRNA." [GOC:jsg, PMID:3340166, PMID:9342308]
comment: Note that this process has been observed in some archaeal and bacterial species.
subset: gosubset_prok
is_a: GO:0019988 ! charged-tRNA amino acid modification

[Term]
id: GO:0043686
name: co-translational protein modification
namespace: biological_process
def: "The covalent alteration of one or more amino acids occurring in a protein before the protein has been completely translated and released from the ribosome." [GOC:jsg]
synonym: "co-translational amino acid modification" EXACT []
synonym: "co-translational modification" EXACT []
synonym: "cotranslational amino acid modification" EXACT []
synonym: "cotranslational modification" EXACT []
synonym: "cotranslational protein modification" EXACT []
is_a: GO:0006464 ! protein modification process

[Term]
id: GO:0043687
name: post-translational protein modification
namespace: biological_process
def: "The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]
subset: gosubset_prok
synonym: "post-translational amino acid modification" EXACT []
synonym: "post-translational modification" EXACT []
synonym: "posttranslational amino acid modification" EXACT []
synonym: "posttranslational modification" EXACT []
synonym: "posttranslational protein modification" EXACT []
synonym: "PTM" EXACT []
xref: Wikipedia:Posttranslational_modification
is_a: GO:0006464 ! protein modification process

[Term]
id: GO:0043688
name: conversion of aspartyl-tRNA to asparaginyl-tRNA
namespace: biological_process
def: "Process whereby aspartate charged on a tRNA(Asn) is converted to asparaginyl-tRNA." [GOC:jsg, PMID:9789001]
comment: Note that this process has been observed in some archeal and bacterial species.
subset: gosubset_prok
is_a: GO:0019988 ! charged-tRNA amino acid modification

[Term]
id: GO:0043689
name: cell-cell adhesion involved in flocculation
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules, occurring as a part of the non-sexual aggregation of single-celled organisms." [GOC:jl]
subset: gosubset_prok
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0000128 ! flocculation

[Term]
id: GO:0043690
name: cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction
namespace: biological_process
def: "The attachment of one cell to another cell via protein-carbohydrate (flocculin-mannan) interaction, occurring as a part of the mannose-sensitive, nonsexual aggregation of cells." [GOC:jl]
subset: gosubset_prok
is_a: GO:0007157 ! heterophilic cell adhesion
is_a: GO:0016339 ! calcium-dependent cell-cell adhesion
is_a: GO:0043689 ! cell-cell adhesion involved in flocculation
relationship: part_of GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction

[Term]
id: GO:0043691
name: reverse cholesterol transport
namespace: biological_process
def: "The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism." [GOC:ecd, PMID:7751809]
is_a: GO:0030301 ! cholesterol transport

[Term]
id: GO:0043692
name: monoterpene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monoterpenes, terpenes with a C10 structure." [ChEBI:35187]
subset: gosubset_prok
synonym: "monoterpene metabolism" EXACT []
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:0043693
name: monoterpene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monoterpenes, terpenes with a C10 structure." [ChEBI:35187]
subset: gosubset_prok
synonym: "monoterpene biosynthesis" EXACT []
is_a: GO:0043692 ! monoterpene metabolic process
is_a: GO:0046246 ! terpene biosynthetic process

[Term]
id: GO:0043694
name: monoterpene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monoterpenes, terpenes with a C10 structure." [ChEBI:35187]
subset: gosubset_prok
synonym: "monoterpene catabolism" EXACT []
is_a: GO:0043692 ! monoterpene metabolic process
is_a: GO:0046247 ! terpene catabolic process

[Term]
id: GO:0043695
name: detection of pheromone
namespace: biological_process
def: "The series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal." [GOC:mah]
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0019236 ! response to pheromone

[Term]
id: GO:0043696
name: dedifferentiation
namespace: biological_process
def: "The process whereby a specialized structure (cell, tissue or organ) loses structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these structures can revert back to the features of their ancestors." [GOC:dph, GOC:pg]
xref: Wikipedia:Cellular_differentiation#Dedifferentiation
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0043697
name: cell dedifferentiation
namespace: biological_process
def: "The process whereby a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:dph, GOC:pg]
comment: Note that this term should be used to annotate gene products involved in dedifferentiation that occurs as part of a normal process, such as regeneration. It should not be used for dedifferentiation that occurs in an abnormal or disease state such as cancer.
is_a: GO:0043696 ! dedifferentiation
is_a: GO:0048869 ! cellular developmental process

[Term]
id: GO:0043698
name: iridosome
namespace: cellular_component
def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which purines crystalize in reflective stacks. Iridosomes are synthesized in iridophore cells and are silver, gold or iridescent in appearance." [GOC:mh]
synonym: "reflecting platelet" EXACT []
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0043699
name: leucosome
namespace: cellular_component
def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which uric acid and/or purines crystalize in reflective stacks. Leucosomes are synthesized in leucophore cells and have a whitish cast." [GOC:mh]
synonym: "refractosome" EXACT []
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0043700
name: pterinosome
namespace: cellular_component
def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which pteridine pigments are synthesized and stored. Pterinosomes are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh]
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0043701
name: cyanosome
namespace: cellular_component
def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which an unknown blue pigment is localized. Cyanosomes are synthesized in cyanophores and are blue in appearance." [GOC:mh]
is_a: GO:0048770 ! pigment granule

[Term]
id: GO:0043702
name: carotenoid vesicle
namespace: cellular_component
def: "A tissue-specific cytoplasmic vesicle surrounded by a membrane half-leaflet within which carotenoid pigments are stored. Carotenoid vescicles are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh]
is_a: GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0043703
name: photoreceptor cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a photoreceptor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu]
is_a: GO:0048664 ! neuron fate determination
relationship: part_of GO:0046552 ! photoreceptor cell fate commitment

[Term]
id: GO:0043704
name: photoreceptor cell fate specification
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:mtg_sensu]
is_a: GO:0048665 ! neuron fate specification
relationship: part_of GO:0046552 ! photoreceptor cell fate commitment

[Term]
id: GO:0043705
name: cyanophycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyanophycin, a non-protein, non-ribosomally produced amino acid polymer composed of an aspartic acid backbone and arginine side groups." [GOC:jl]
synonym: "cyanophycin metabolism" EXACT []
synonym: "multi-L-arginyl-poly(L-aspartic acid) metabolism" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0043706
name: heterophilic cell adhesion involved in cytoadherence to microvasculature, mediated by parasite protein
namespace: biological_process
def: "The attachment of a parasite adhesion molecule to a nonidentical adhesion molecule on the microvasculature of a host cell, thereby adhering the parasite to the host cell." [GOC:jl]
is_a: GO:0007157 ! heterophilic cell adhesion
relationship: part_of GO:0020035 ! cytoadherence to microvasculature, mediated by parasite protein

[Term]
id: GO:0043707
name: cell adhesion during single-species biofilm formation in or on host organism
namespace: biological_process
def: "The attachment of a cell to either a host cell or a microbial cell of the same species, or to an underlying host substrate, such as the extracellular matrix, via cell adhesion molecules, occurring during the formation of a biofilm in or on a surface in a host species." [GOC:jl]
is_a: GO:0043709 ! cell adhesion during single-species biofilm formation
relationship: part_of GO:0044407 ! single-species biofilm formation in or on host organism

[Term]
id: GO:0043708
name: cell adhesion during biofilm formation
namespace: biological_process
def: "The attachment of a cell to a surface, via cell adhesion molecules, during the formation of a biofilm." [GOC:jl]
is_a: GO:0007155 ! cell adhesion
relationship: part_of GO:0042710 ! biofilm formation

[Term]
id: GO:0043709
name: cell adhesion during single-species biofilm formation
namespace: biological_process
def: "The attachment of a cell to a surface, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species." [GOC:jl]
is_a: GO:0043708 ! cell adhesion during biofilm formation
relationship: part_of GO:0044010 ! single-species biofilm formation

[Term]
id: GO:0043710
name: cell adhesion during multi-species biofilm formation
namespace: biological_process
def: "The attachment of a cell to a surface, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of different species." [GOC:jl]
is_a: GO:0043708 ! cell adhesion during biofilm formation
relationship: part_of GO:0044399 ! multi-species biofilm formation

[Term]
id: GO:0043711
name: pilus organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies." [GOC:jl]
subset: gosubset_prok
synonym: "pilus organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030030 ! cell projection organization

[Term]
id: GO:0043712
name: 2-hydroxyisocaproate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoisocaproate + CoA = (R)-2-hydroxyisocaproyl-CoA." [PMID:16957230]
synonym: "(R)-2-hydroxyisocaproate CoA transferase activity" EXACT []
synonym: "(R)-2-hydroxyisocaproate CoA-transferase activity" EXACT []
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0043713
name: (R)-2-hydroxyisocaproate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+." [GOC:jl, PMID:16957230]
subset: gosubset_prok
xref: EC:1.1.1.-
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043714
name: (R)-citramalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + acetyl-CoA + H2O = (R)-citramalate + CoA." [GOC:jl, PMID:9864346]
subset: gosubset_prok
synonym: "citramalate synthase" BROAD []
xref: EC:2.3.3.-
xref: MetaCyc:RXN-7743
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0043715
name: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity
namespace: molecular_function
def: "Catalysis of the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P)." [MetaCyc:R82-RXN]
comment: This function is part of the process of methionine salvage.
subset: gosubset_prok
synonym: "DK-MTP-1-P enolase activity" EXACT []
synonym: "E-1" RELATED []
synonym: "MasA" RELATED []
synonym: "mtnW" RELATED []
xref: EC:5.3.2.-
xref: MetaCyc:R82-RXN
is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups

[Term]
id: GO:0043716
name: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity
namespace: molecular_function
def: "Cataysis of the dephosphorylation of 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-P) to 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)." [IMG:01681, MetaCyc:R83-RXN]
subset: gosubset_prok
synonym: "2-hydroxy-3-keto-5-methylthio-phosphopentene phosphatase activity" EXACT [MetaCyc:R83-RXN]
synonym: "HK-MTPenyl-1-P phosphatase activity" EXACT []
xref: MetaCyc:R83-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0043717
name: 2-hydroxyglutaryl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the dehydration of 2-hydroxyglutaryl-CoA to glutaconyl-CoA." [MetaCyc:RXN-1083]
subset: gosubset_prok
synonym: "(R)-2-hydroxyglutaryl-CoA dehydratase activity" EXACT []
xref: MetaCyc:RXN-1083
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043718
name: 2-hydroxymethylglutarate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxymethylglutarate + NAD+ = 2-formylglutarate + NADH + H+." [EC:1.1.1.291]
subset: gosubset_prok
synonym: "(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.291]
synonym: "HgD" EXACT []
xref: EC:1.1.1.291
xref: MetaCyc:1.1.1.291-RXN
xref: Wikipedia:2-hydroxymethylglutarate_dehydrogenase
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043719
name: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol +O2 + H+ = 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + H2O." [GOC:jl, MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN]
subset: gosubset_prok
xref: EC:1.14.13.-
xref: MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0043720
name: 3-keto-5-aminohexanoate cleavage activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate." [PMID:13064]
subset: gosubset_prok
synonym: "3-keto-5-aminohexanoate cleavage enzyme" EXACT []
xref: MetaCyc:R125-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0043721
name: 4-hydroxybutyryl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the formation of vinylacetyl-CoA from 4-hydroxybutyryl-CoA." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "gamma-hydroxybutyryl-CoA dehydratase activity" EXACT []
xref: EC:4.2.1.-
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043722
name: 4-hydroxyphenylacetate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (4-hydroxyphenyl)acetate + H+ = 4-methylphenol + CO2." [EC:4.1.1.83]
subset: gosubset_prok
synonym: "4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming)" EXACT [EC:4.1.1.83]
synonym: "4-Hpd activity" EXACT [EC:4.1.1.83]
synonym: "4-hydroxyphenylacetate carboxy-lyase activity" EXACT [EC:4.1.1.83]
synonym: "p-Hpd activity" EXACT [EC:4.1.1.83]
synonym: "p-hydroxyphenylacetate decarboxylase activity" EXACT [EC:4.1.1.83]
xref: EC:4.1.1.83
xref: MetaCyc:4.1.1.83-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0043723
name: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate + NH3." [PMID:11889103]
subset: gosubset_prok
synonym: "2,5-diamino-6-(5-phosphoribitylamino)pyrimidin-4(3H)-one deaminase activity" EXACT []
xref: EC:3.5.4.-
xref: MetaCyc:RXN-10058
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0043724
name: 2-keto-3-deoxygalactonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate." [PMID:12824170]
subset: gosubset_prok
synonym: "KDGal aldolase activity" EXACT []
xref: EC:4.2.1.-
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043725
name: 2-keto-3-deoxygluconate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-keto-3-deoxygluconate = D-glyceraldehyde + pyruvate." [PMID:12824170]
subset: gosubset_prok
synonym: "KDG aldolase activity" EXACT []
xref: EC:4.2.1.-
xref: MetaCyc:DHDOGALDOL-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043726
name: 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity
namespace: molecular_function
alt_id: GO:0019173
def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate." [GOC:jl, IMG:01282]
subset: gosubset_prok
synonym: "pyrimidine phosphatase activity" EXACT [GOC:mah]
xref: EC:3.1.3.-
xref: MetaCyc:RIBOPHOSPHAT-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0043727
name: 5-amino-4-imidazole carboxylate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate." [GOC:jl, IMG:01835]
subset: gosubset_prok
xref: EC:4.1.1.-
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0043728
name: 2-keto-4-methylthiobutyrate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine." [GOC:jl, IMG:01683]
subset: gosubset_prok
xref: EC:4.1.1.-
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0043729
name: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate." [GOC:jl, IMG:01536]
subset: gosubset_prok
xref: EC:4.-.-.-
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0043730
name: 5-ureido-4-imidazole carboxylate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2." [GOC:jl, IMG:02121]
subset: gosubset_prok
xref: EC:3.5.3.-
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0043731
name: 6-hydroxynicotinate 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD." [GOC:jl, PMID:10091591]
subset: gosubset_prok
xref: EC:1.14.13.-
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0043732
name: 6-hydroxynicotinate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O." [EC:1.17.3.3]
subset: gosubset_prok
synonym: "6-hydroxynicotinate hydroxylase activity" EXACT [EC:1.17.3.3]
synonym: "6-hydroxynicotinate:O2 oxidoreductase activity" EXACT [EC:1.17.3.3]
synonym: "6-hydroxynicotinic acid dehydrogenase activity" EXACT [EC:1.17.3.3]
synonym: "6-hydroxynicotinic acid hydroxylase activity" EXACT [EC:1.17.3.3]
xref: EC:1.17.3.3
is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor

[Term]
id: GO:0043733
name: DNA-3-methyladenine glycosylase III activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated 3-methylpurines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site." [IMG:00576, PMID:10777493, PMID:14517230]
subset: gosubset_prok
synonym: "Mag III" NARROW []
synonym: "MagIII" NARROW []
xref: EC:3.2.2.-
xref: IMG:00576
is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity

[Term]
id: GO:0043734
name: DNA-N1-methyladenine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA and RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methylgroup on N1-methyladenine and N3-methylcytosine as formaldehyde." [IMG:00579, PMID:19786499]
subset: gosubset_prok
synonym: "AlkB" NARROW []
synonym: "alkB" NARROW []
synonym: "alpha-ketoglutarate-dependent dioxygenase" NARROW []
xref: EC:1.14.11.-
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0043736
name: DNA-3-methyladenine glycosylase IV activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alkylated DNA; recognizes and removes both N-3- and N-7-methyl purines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [IMG:00578, PMID:10375529]
subset: gosubset_prok
synonym: "Mpg II" NARROW []
synonym: "MpgII" NARROW []
xref: EC:3.2.2.-
xref: IMG:00578
is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity

[Term]
id: GO:0043737
name: deoxyribonuclease V activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate." [EC:3.1.21.7]
synonym: "DNase V activity" EXACT [EC:3.1.21.7]
synonym: "endodeoxyribonuclease V" EXACT []
synonym: "endonuclease V activity" BROAD [EC:3.1.21.7]
synonym: "Escherichia coli endodeoxyribonuclease V activity" NARROW [EC:3.1.21.7]
xref: EC:3.1.21.7
xref: MetaCyc:3.1.21.7-RXN
is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0043738
name: F420H2 dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methanophenazine + reduced cofactor F420 = dihydromethanophenazine + cofactor F420." [MetaCyc:CPLX-7105]
subset: gosubset_prok
xref: EC:1.-.-.-
xref: MetaCyc:CPLX-7105
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043739
name: G/U mismatch-specific uracil-DNA glycosylase activity
namespace: molecular_function
def: "Catalysis of the removal of uracil from a U*G mispair by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free uracil and leaves an apyrimidinic (AP) site." [IMG:00570, SP:O59825]
subset: gosubset_prok
synonym: "GU mismatch-specific uracil-DNA glycosylase activity" EXACT []
synonym: "MUG" EXACT []
synonym: "uracil mismatch repair protein" BROAD []
is_a: GO:0004844 ! uracil DNA N-glycosylase activity
is_a: GO:0008263 ! pyrimidine-specific mismatch base pair DNA N-glycosylase activity

[Term]
id: GO:0043740
name: GTP cyclohydrolase IIa activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + 2 phosphate." [EC:3.5.4.29]
subset: gosubset_prok
synonym: "GTP 8,9-dihydrolase (phosphate-forming)" EXACT [EC:3.5.4.29]
synonym: "GTP 8,9-hydrolase (phosphate-forming)" EXACT []
synonym: "GTP cyclohydrolase III activity" NARROW [EC:3.5.4.29]
xref: EC:3.5.4.29
xref: MetaCyc:3.5.4.29-RXN
is_a: GO:0003933 ! GTP cyclohydrolase activity

[Term]
id: GO:0043741
name: L-2-aminoadipate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-aminoadipate + acetyl-CoA = N2-acetyl-L-aminoadipate + CoA." [IMG:01447]
subset: gosubset_prok
xref: EC:2.3.1.-
xref: MetaCyc:RXN-5181
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0043743
name: LPPG:FO 2-phospho-L-lactate transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP." [IMG:01551]
subset: gosubset_prok
xref: EC:2.7.1.-
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043744
name: N2-acetyl-L-aminoadipate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-acetyl-L-aminoadipate + ATP = N2-acetyl-L-aminoadipyl-delta-phosphate + ADP." [IMG:01448]
subset: gosubset_prok
xref: EC:2.7.2.-
xref: MetaCyc:RXN-5182
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0043745
name: N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-acetyl-L-aminoadipyl-delta-phosphate + NADPH + H+ = N2-acetyl-L-aminoadipate semialdehyde + NADP+ + orthophosphate." [IMG:01449]
subset: gosubset_prok
xref: EC:1.2.1.-
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043746
name: N2-acetyl-L-lysine aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-acetyl-L-aminoadipate semialdehyde + L-glutamate = 2-oxoglutarate + N2-acetyl-L-lysine." [IMG:01450]
subset: gosubset_prok
synonym: "N-acetyl-lysine aminotransferase activity" EXACT []
xref: EC:2.6.1.-
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0043747
name: N2-acetyl-L-lysine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-acetyl-L-lysine + H2O = acetate + L-lysine." [IMG:01451]
subset: gosubset_prok
synonym: "N-acetyl-lysine deacetylase activity" EXACT []
xref: EC:3.5.1.-
xref: MetaCyc:RXN-5185
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0043748
name: O-succinylbenzoate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate." [IMG:01733]
subset: gosubset_prok
xref: EC:3.5.1.-
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043749
name: phenol, water dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate." [PMID:15547277]
subset: gosubset_prok
synonym: "ATP:phenol:water phosphotransferase activity" EXACT []
synonym: "phenol:water dikinase activity" EXACT []
synonym: "phenylphosphate synthase activity" EXACT []
xref: EC:2.7.9.-
is_a: GO:0016301 ! kinase activity
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0043750
name: phosphatidylinositol alpha-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol." [EC:2.4.1.57]
subset: gosubset_prok
synonym: "GDP mannose-phosphatidyl-myo-inositol alpha-mannosyltransferase activity" EXACT [EC:2.4.1.57]
synonym: "GDP mannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.57]
synonym: "GDP-mannose:1-phosphatidyl-1D-myo-inositol alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.57]
synonym: "GDPmannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.57]
synonym: "guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase activity" EXACT [EC:2.4.1.57]
synonym: "phosphatidyl-myo-inositol alpha-mannosyltransferase activity" EXACT [EC:2.4.1.57]
xref: EC:2.4.1.57
xref: MetaCyc:2.4.1.57-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0043751
name: polyphosphate:AMP phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (polyphosphate)n + AMP = (polyphosphate)n-1 + ADP." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "PAP" EXACT []
synonym: "PPT" EXACT []
xref: EC:2.7.4.-
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0043752
name: adenosylcobinamide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP)." [EC:2.7.1.156]
subset: gosubset_prok
synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD []
synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD []
synonym: "CobU" RELATED []
synonym: "RTP:adenosylcobinamide phosphotransferase activity" EXACT []
xref: EC:2.7.1.156
xref: MetaCyc:2.7.1.156-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043753
name: adenosylcobinamide-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + adenosylcobinamide phosphate = diphosphate + adenosylcobinamide-GDP." [EC:2.7.7.62]
subset: gosubset_prok
synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD []
synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD []
synonym: "CobU" RELATED []
synonym: "GTP:adenosylcobinamide-phosphate guanylyltransferase activity" EXACT []
xref: EC:2.7.7.62
xref: MetaCyc:COBINPGUANYLYLTRANS-RXN
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0043754
name: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine." [EC:2.3.1.168]
subset: gosubset_prok
synonym: "2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity" EXACT [EC:2.3.1.168]
synonym: "2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity" EXACT [EC:2.3.1.168]
synonym: "dihydrolipoyl transacylase activity" EXACT [EC:2.3.1.168]
synonym: "enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase activity" EXACT []
xref: EC:2.3.1.168
xref: MetaCyc:2.3.1.168-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0043755
name: alpha-ribazole phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate." [EC:3.1.3.73]
subset: gosubset_prok
synonym: "alpha-ribazole-5'-phosphate phosphohydrolase activity" EXACT []
synonym: "CobC" RELATED []
xref: EC:3.1.3.73
xref: MetaCyc:RIBAZOLEPHOSPHAT-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0043756
name: adenosylcobinamide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosylcobinamide + H2O = adenosylcobyric acid + (R)-1-aminopropan-2-ol." [EC:3.5.1.90]
subset: gosubset_prok
synonym: "adenosylcobinamide amidohydrolase activity" EXACT [EC:3.5.1.90]
synonym: "AdoCbi amidohydrolase activity" EXACT [EC:3.5.1.90]
synonym: "AdoCbi hydrolase activity" EXACT [EC:3.5.1.90]
synonym: "CbiZ" RELATED []
xref: EC:3.5.1.90
xref: MetaCyc:R346-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0043757
name: adenosylcobinamide-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reactions: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate and (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide." [EC:6.3.1.10]
subset: gosubset_prok
synonym: "adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming)" EXACT []
synonym: "AdoCbi-P synthase activity" EXACT [EC:6.3.1.10]
synonym: "CbiB" RELATED []
xref: EC:6.3.1.10
xref: MetaCyc:RXN-6261
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0043758
name: acetate-CoA ligase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA." [EC:6.2.1.13]
subset: gosubset_prok
synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.13]
synonym: "acetate--CoA ligase (ADP-forming) activity" EXACT []
synonym: "acetate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.13]
synonym: "acetyl coenzyme A synthetase (adenosine diphosphate-forming)" EXACT []
synonym: "acetyl-CoA synthetase (ADP-forming) activity" EXACT [EC:6.2.1.13]
xref: EC:6.2.1.13
xref: MetaCyc:ACETATE--COA-LIGASE-ADP-FORMING-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0043759
name: branched-chain acyl-CoA synthetase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2-methylbutanoate + CoA = ADP + orthophosphate + 2-methylbutanoyl-CoA." [IMG:01425]
subset: gosubset_prok
synonym: "branched chain acyl CoA synthetase (ADP-forming) activity" EXACT []
synonym: "branched chain acyl-CoA synthetase (ADP-forming) activity" EXACT []
synonym: "branched-chain acyl CoA synthetase (ADP-forming) activity" EXACT []
xref: EC:6.2.1.-
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0043760
name: acetyldiaminopimelate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate." [IMG:00444, PMID:1906065]
subset: gosubset_prok
synonym: "N-acetyl-diaminopimelate aminotransferase activity" EXACT []
synonym: "N-acetyl-L,L-diaminopimelate aminotransferase activity" EXACT []
xref: EC:2.6.1.-
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0043761
name: archaetidylserine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP." [IMG:01567, PMID:12562787]
subset: gosubset_prok
synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol inositol 1-archaetidyltransferase activity" EXACT []
synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol:l-serine O-archaetidyltransferase activity" EXACT []
xref: EC:2.7.8.-
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0043762
name: aryl-CoA synthetase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + phenylacetate + CoA = ADP + orthophosphate + phenylacetyl-CoA." [IMG:01427]
subset: gosubset_prok
xref: EC:6.2.1.-
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0043763
name: UTP:glucose-1-phosphate uridylyltransferase regulator activity
namespace: molecular_function
def: "Modulates the activity of UTP:glucose-1-phosphate uridylyltransferase." [GOC:jl]
subset: gosubset_prok
synonym: "glucose-1-phosphate uridylyltransferase regulator activity" EXACT []
synonym: "UDP-glucose diphosphorylase regulator activity" EXACT []
synonym: "UDP-glucose pyrophosphorylase regulator activity" EXACT []
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0043764
name: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl- [acyl carrier protein] = UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl carrier protein]." [IMG:00545, InterPro:IPR007691]
subset: gosubset_prok
xref: EC:2.3.1.-
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0043765
name: T/G mismatch-specific endonuclease activity
namespace: molecular_function
def: "Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine." [IMG:00606, SP:P09184]
subset: gosubset_prok
synonym: "DNA mismatch endonuclease" BROAD []
synonym: "V.EcoKDcm" RELATED []
synonym: "very short patch repair protein" RELATED []
synonym: "Vsr mismatch endonuclease" RELATED []
xref: EC:3.1.-.-
is_a: GO:0004519 ! endonuclease activity

[Term]
id: GO:0043766
name: Sep-tRNA:Cys-tRNA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoseryl-tRNA(Cys) + H2S = cysteinyl-tRNA(Cys) + orthophosphate." [IMG:00235, PMID:15790858, PMID:16380427, PMID:17110438]
subset: gosubset_prok
synonym: "O-phosphoseryl-tRNA:cysteinyl-tRNA synthase activity" EXACT []
synonym: "Sep-tRNA:Cys-tRNA synthetase activity" EXACT []
synonym: "SepCysS" RELATED []
xref: EC:2.5.1.-
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0043767
name: pyrrolysyl-tRNA synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + pyrophosphate + L-pyrrolysyl-tRNA(Pyl)." [IMG:02553, PMID:15314242, SP:Q8TUB8]
subset: gosubset_prok
synonym: " Pyrrolysine-tRNA ligase activity" EXACT []
synonym: "PylRS" EXACT []
xref: EC:6.1.1.-
xref: MetaCyc:6.1.1.26-RXN
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0043768
name: S-ribosylhomocysteine lyase activity
namespace: molecular_function
alt_id: GO:0019138
def: "Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (S)-4,5-dihydroxypentan-2,3-dione." [EC:4.4.1.21, IMG:02085]
subset: gosubset_prok
synonym: "3.2.1.148" RELATED []
synonym: "LuxS" RELATED []
synonym: "ribosylhomocysteinase activity" EXACT []
synonym: "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]" RELATED [EC:4.4.1.21]
synonym: "S-ribosylhomocysteinase activity" EXACT []
xref: EC:4.4.1.21
xref: MetaCyc:RIBOSYLHOMOCYSTEINASE-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0043769
name: Tpg-containing telomere binding complex
namespace: cellular_component
def: "A complex composed of four polypeptides, a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA), that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species." [PMID:15353591]
subset: gosubset_prok
synonym: "telomere complex" BROAD []
is_a: GO:0000782 ! telomere cap complex

[Term]
id: GO:0043770
name: demethylmenaquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine." [IMG:01848]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043771
name: cytidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + cytidine = ADP + CMP." [IMG:01870]
subset: gosubset_prok
xref: EC:2.7.1.-
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019206 ! nucleoside kinase activity

[Term]
id: GO:0043772
name: acyl-phosphate glycerol-3-phosphate acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate." [IMG:01872, PMID:17308305]
subset: gosubset_prok
synonym: "acyl-phosphate:glycerol-3-phosphate acyltransferase activity" EXACT []
synonym: "acylphosphate glycerol-3-phosphate acyltransferase activity" EXACT []
synonym: "acylphosphate:glycerol-3-phosphate acyltransferase activity" EXACT []
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0043773
name: coenzyme F420-0 gamma-glutamyl ligase activity
namespace: molecular_function
def: "Catalyzes the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates, i.e. GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1 followed by GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2." [IMG:01552, PMID:17669425]
subset: gosubset_prok
synonym: "F420-0 gamma-glutamyl ligase activity" EXACT []
xref: EC:6.3.2.-
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0043774
name: coenzyme F420-2 alpha-glutamyl ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate." [IMG:01553]
subset: gosubset_prok
synonym: "F420-2 alpha-glutamyl ligase activity" EXACT []
xref: EC:6.3.2.-
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0043775
name: cobyrinate a,c-diamide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobyrinate + 2 L-glutamine + 2 ATP + 2 H2O = cob(II)yrinate a,c-diamide + 2 L-glutamate + 2 ADP + 2 orthophosphate." [IMG:01814]
subset: gosubset_prok
synonym: "cobyrinate a c diamide synthase activity" EXACT []
synonym: "cobyrinate a c-diamide synthase activity" EXACT []
synonym: "cobyrinate a,c diamide synthase activity" EXACT []
xref: EC:6.3.5.-
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0043776
name: cobalt-precorrin-6B C5-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7." [IMG:02115, MetaCyc:RXN-8766]
subset: gosubset_prok
synonym: "cobalt-precorrin 6B C5-methyltransferase activity" EXACT []
synonym: "precorrin-6 methyltransferase activity" EXACT []
synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD []
synonym: "precorrin-6Y methylase" BROAD []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8766
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043777
name: cobalt-precorrin-7 C15-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2." [IMG:02116, MetaCyc:RXN-8767]
subset: gosubset_prok
synonym: "cobalt-precorrin 7 C15-methyltransferase activity" EXACT []
synonym: "precorrin-6 methyltransferase" BROAD []
synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD []
synonym: "precorrin-6Y methylase" BROAD []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8767
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043778
name: cobalt-precorrin-8 methylmutase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 8 = cobyrinate." [IMG:02117, MetaCyc:RXN-8768]
subset: gosubset_prok
synonym: "cobalt-precorrin 8 methylmutase activity" EXACT []
synonym: "cobalt-precorrin 8X methylmutase activity" EXACT []
synonym: "cobalt-precorrin-8X methylmutase activity" EXACT []
xref: EC:5.4.1.-
xref: MetaCyc:RXN-8768
is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups

[Term]
id: GO:0043779
name: cobalt-precorrin-5A acetaldehyde-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde." [IMG:02112, MetaCyc:RXN-8763]
subset: gosubset_prok
synonym: "cobalt-precorrin 5A acetaldehyde-lyase activity" EXACT []
xref: MetaCyc:RXN-8763
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0043780
name: cobalt-precorrin-5B C1-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A." [IMG:02112, MetaCyc:RXN-8764]
subset: gosubset_prok
synonym: "cobalt-precorrin 5B C1-methyltransferase activity" EXACT []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8764
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043781
name: cobalt-factor II C20-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III." [EC:2.1.1.151, IMG:01812]
subset: gosubset_prok
synonym: "CbiL" NARROW []
synonym: "cobalt-factor II C20 methyltransferase activity" EXACT []
synonym: "cobalt-precorrin-2 C(20)-methyltransferase activity" EXACT [EC:2.1.1.151]
synonym: "S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase activity" EXACT [EC:2.1.1.151]
xref: EC:2.1.1.151
xref: MetaCyc:RXN-8760
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043782
name: cobalt-precorrin-3 C17-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cobalt-precorrin 3 + S-adenosyl-L-methionine = cobalt-precorrin 4 + S-adenosyl-L-homocysteine." [IMG:02110, MetaCyc:RXN-8761]
subset: gosubset_prok
synonym: "cobalt-precorrin 3 C17-methyltransferase activity" EXACT []
synonym: "cobalt-precorrin-3 methylase" BROAD []
synonym: "cobalt-precorrin-3 methyltransferase" BROAD []
synonym: "cobalt-precorrin-3B C17-methyltransferase activity" EXACT []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8761
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043783
name: oxidoreductase activity, oxidizing metal ions with flavin as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and flavin acts as an electron acceptor." [EC:1.16.8]
subset: gosubset_prok
xref: EC:1.16.8
is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions

[Term]
id: GO:0043784
name: cob(II)yrinic acid a,c-diamide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 cob(II)yrinic acid a,c-diamide + FMN = 2 cob(I)yrinic acid a,c-diamide + FMNH2." [EC:1.16.8.1]
subset: gosubset_prok
synonym: "cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase activity" EXACT []
xref: EC:1.16.8.1
xref: MetaCyc:R343-RXN
is_a: GO:0043783 ! oxidoreductase activity, oxidizing metal ions with flavin as acceptor

[Term]
id: GO:0043785
name: cinnamoyl-CoA:phenyllactate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-cinnamoyl-CoA + (R)-phenyllactate = (E)-cinnamate + (R)-phenyllactyl-CoA." [EC:2.8.3.17]
subset: gosubset_prok
synonym: "(E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase activity" EXACT []
synonym: "FldA" RELATED []
xref: EC:2.8.3.17
xref: MetaCyc:2.8.3.17-RXN
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0043786
name: cinnamate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phenylpropanoate + NAD+ = (E)-cinnamate + NADH + H+." [EC:1.3.1.-, IMG:01615, PMID:10849007]
subset: gosubset_prok
xref: EC:1.3.1.-
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043787
name: chlorophyll synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlorophyllide a + phytyl diphosphate = chlorophyll a + diphosphate." [EC:2.5.1.62, IMG:01750]
subset: gosubset_prok
synonym: "chlorophyllide-a:phytyl-diphosphate phytyltransferase activity" EXACT []
xref: EC:2.5.1.62
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0043788
name: cardiolipin synthetase 2 activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 1,2-diacyl-sn-glycero-3-[phospho-rac-(1-glycerol)] = cardiolipin + glycerol." [IMG:00156]
subset: gosubset_prok
synonym: "cardiolipin synthase 2 activity" EXACT []
xref: EC:2.7.8.-
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0043789
name: diguanylate cyclase activity
namespace: molecular_function
def: "Catalysis of the conversion of 2GTP to bis-(3'-5')cyclic guanylic acid, via linear diguanosine tetraphosphate pppg 3'p5'g, releasing 1 pyrophosphate at each step." [http://cancerweb.ncl.ac.uk/, IMG:02393, PMID:16895465]
subset: gosubset_prok
xref: EC:4.6.1.-
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0043791
name: dimethylamine methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine." [IMG:01321, MetaCyc:RXN-8100, PMID:9874228]
comment: This function is the first step in the pathway of methanogenesis from dimethylamine.
subset: gosubset_prok
synonym: "dimethylamine:corrinoid methyltransferase activity" EXACT []
synonym: "DMA methyltransferase 1" EXACT []
synonym: "DMAMT 1" EXACT []
synonym: "MT1" BROAD []
synonym: "mtbB1" RELATED []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8100
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043792
name: enamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-oxo-1,4,5,6-tetrahydronicotinate + 2 H2O = 2-formylglutarate + NH." [EC:3.5.2.18]
subset: gosubset_prok
synonym: "6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase activity" EXACT []
xref: EC:3.5.2.18
xref: MetaCyc:3.5.2.18-RXN
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0043793
name: beta-ribofuranosylaminobenzene 5'-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + pyrophosphate." [GOC:jl, IMG:01544, PMID:12142414]
subset: gosubset_prok
synonym: "beta-RFAP synthase activity" EXACT []
xref: MetaCyc:RXN-8124
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0043794
name: formate dehydrogenase (F420) activity
namespace: molecular_function
def: "Catalysis of the reaction: formate + coenzyme F420 = CO2 + reduced coenzyme F420." [IMG:01432, PMID:3801411]
subset: gosubset_prok
xref: EC:1.2.99.-
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0043795
name: glyceraldehyde oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor." [IMG:01506]
subset: gosubset_prok
xref: EC:1.2.-.-.
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0043796
name: glyceraldehyde dehydrogenase (NADP) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+." [IMG:01555]
subset: gosubset_prok
xref: EC:1.2.1.-
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043797
name: glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin." [EC:1.2.7.6]
subset: gosubset_prok
synonym: "D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase activity" EXACT []
synonym: "GAPOR" RELATED []
synonym: "glyceraldehyde-3-phosphate Fd oxidoreductase activity" EXACT [EC:1.2.7.6]
synonym: "glyceraldehyde-3-phosphate ferredoxin reductase activity" EXACT [EC:1.2.7.6]
xref: EC:1.2.7.6
xref: MetaCyc:1.2.7.6-RXN
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0043798
name: glycerate 2-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP." [IMG:01510, MetaCyc:GKI-RXN, PMID:14413719]
subset: gosubset_prok
synonym: "D-glycerate 2-kinase activity" EXACT []
synonym: "glycerate kinase" BROAD []
xref: EC:2.7.1.-
xref: MetaCyc:GKI-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor

[Term]
id: GO:0043799
name: glycine oxidase activity
namespace: molecular_function
def: "Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + H2O2 (2) D-alanine + H2O + O2 = pyruvate + NH3 + H2O2 (3) sarcosine + H2O + O2 = glyoxylate + methylamine + H2O2 (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + H2O2." [EC:1.4.3.19]
subset: gosubset_prok
synonym: "glycine:oxygen oxidoreductase (deaminating)" EXACT []
xref: EC:1.4.3.19
xref: MetaCyc:1.4.3.19-RXN
xref: MetaCyc:RXN-8672
xref: MetaCyc:RXN-8673
xref: MetaCyc:RXN-8674
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0043800
name: hexulose-6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate." [IMG:01502, MetaCyc:R12-RXN, PMID:11839305]
subset: gosubset_prok
synonym: "HUMPI" EXACT []
xref: EC:5.-.-.-
xref: MetaCyc:R12-RXN
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0043801
name: hexulose-6-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate." [IMG:01503, PMID:16075199]
subset: gosubset_prok
xref: EC:4.1.2.-
xref: MetaCyc:R10-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0043802
name: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ATP + hydrogenobyrinic acid + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + hydrogenobyrinic acid a,c-diamide + 2 L-glutamate." [EC:6.3.5.9]
subset: gosubset_prok
synonym: "CobB" RELATED []
synonym: "hydrogenobyrinic acid a,c diamide synthase (glutamine-hydrolysing) activity" EXACT []
synonym: "hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming)" EXACT []
xref: EC:6.3.5.9
xref: MetaCyc:R341-RXN
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0043803
name: hydroxyneurosporene-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: demethylspheroidene + S-adenosyl-L-methionine = spheroidene + S-adenosyl-L-homocysteine." [IMG:01759]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043804
name: imidazolone hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formiminoglycine = imidazolone + H2O." [IMG:02122]
subset: gosubset_prok
xref: EC:3.5.2.-
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0043805
name: indolepyruvate ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.8]
subset: gosubset_prok
synonym: "3-(indol-3-yl)pyruvate synthase (ferredoxin) activity" EXACT [EC:1.2.7.8]
synonym: "3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating)" EXACT [EC:1.2.7.8]
synonym: "indolepyruvate oxidoreductase activity" EXACT [EC:1.2.7.8]
synonym: "IOR" RELATED []
xref: EC:1.2.7.8
xref: MetaCyc:1.2.7.8-RXN
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0043806
name: keto acid formate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxobutanoate + CoA = propionyl-CoA + formate." [IMG:00725, MetaCyc:KETOBUTFORMLY-RXN]
subset: gosubset_prok
synonym: "keto-acid formate acetyltransferase" BROAD []
synonym: "keto-acid formate lyase activity" EXACT []
synonym: "keto-acid formate-lyase activity" EXACT []
xref: EC:2.3.1.-
xref: MetaCyc:KETOBUTFORMLY-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0043807
name: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.7]
subset: gosubset_prok
synonym: "2-ketoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7]
synonym: "2-oxoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7]
synonym: "3-methyl-2-oxobutanoate synthase (ferredoxin) activity" EXACT [EC:1.2.7.7]
synonym: "3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylpropanoylating)" EXACT []
synonym: "branched-chain ketoacid ferredoxin reductase activity" RELATED [EC:1.2.7.7]
synonym: "branched-chain oxo acid ferredoxin reductase activity" RELATED [EC:1.2.7.7]
synonym: "keto-valine-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.7]
synonym: "ketoisovalerate ferredoxin reductase activity" EXACT [EC:1.2.7.7]
synonym: "ketoisovalerate oxidoreductase activity" EXACT [EC:1.2.7.7]
synonym: "VOR" RELATED []
xref: EC:1.2.7.7
xref: MetaCyc:1.2.7.7-RXN
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0043808
name: lyso-ornithine lipid acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: lyso-ornithine lipid + acyl-[acyl carrier protein] = ornithine lipid + [acyl carrier protein]." [IMG:02097, PMID:15341653]
subset: gosubset_prok
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0043809
name: methylthioribulose 1-phosphate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H2O." [EC:4.2.1.109]
subset: gosubset_prok
synonym: "1-PMT-ribulose dehydratase activity" EXACT [EC:4.2.1.109]
synonym: "methylthioribulose-1-phosphate dehydratase activity" EXACT []
synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]" RELATED [EC:4.2.1.109]
synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase activity" EXACT []
synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase[5-(methylthio)-2,3-dioxopentyl-phosphate-forming]" EXACT []
xref: EC:4.2.1.109
xref: MetaCyc:R145-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043810
name: ornithine-acyl [acyl carrier protein] N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl carrier protein]." [IMG:02096]
subset: gosubset_prok
synonym: "ornithine-acyl[acyl carrier protein] N-acyltransferase activity" EXACT []
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0043811
name: phosphate:acyl-[acyl carrier protein] acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl carrier protein] + orthophosphate = acyl phosphate + [acyl carrier protein]." [IMG:01871]
subset: gosubset_prok
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0043812
name: phosphatidylinositol-4-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate." [IMG:01360]
subset: gosubset_prok
synonym: "phosphatidylinositol 4-phosphate phosphatase activity" EXACT []
xref: EC:3.1.3.-
is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity

[Term]
id: GO:0043813
name: phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate." [IMG:01359, PMID:10806194, PMID:16607019]
subset: gosubset_prok
synonym: "phosphatidylinositol 3,5-bisphosphate 5-phosphatase activity" EXACT []
xref: EC:3.1.3.-
is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity
is_a: GO:0034595 ! phosphoinositide 5-phosphatase activity

[Term]
id: GO:0043814
name: phospholactate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + pyrophosphate." [IMG:01547]
subset: gosubset_prok
xref: EC:2.7.7.-
xref: MetaCyc:RXN-8077
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0043815
name: phosphoribosylglycinamide formyltransferase 2 activity
namespace: molecular_function
def: "Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate." [IMG:01297, PMID:8117714]
subset: gosubset_prok
synonym: "5'-phosphoribosylglycinamide transformylase 2" EXACT []
synonym: "formate-dependent GAR transformylase activity" EXACT []
synonym: "GAR transformylase 2" RELATED []
synonym: "GART 2" RELATED []
xref: EC:2.1.2.-
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0043816
name: phosphoserine-tRNA(Cys) ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + pyrophosphate + phosphoseryl-tRNA(Cys)." [IMG:00622, PMID:17110438]
subset: gosubset_prok
synonym: "O-phosphoseryl-tRNA(Cys) synthetase activity" EXACT []
synonym: "phosphoserine--tRNA(Cys) ligase activity" EXACT []
synonym: "phosphoserine-tRNACys ligase activity" EXACT []
synonym: "SepRS" RELATED []
xref: EC:6.1.1.-
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0043817
name: phosphosulfolactate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = sulfite + phosphoenolpyruvate." [IMG:00622]
subset: gosubset_prok
synonym: "(2R)-O-phospho-3-sulfolactate sulfo-lyase (phosphoenolpyruvate-forming)" EXACT [EC:4.4.1.19]
synonym: "(2R)-O-phospho-3-sulfolactate sulfo-lyase activity" EXACT []
synonym: "(2R)-phospho-3-sulfolactate synthase activity" EXACT [EC:4.4.1.19]
synonym: "PSL synthase activity" EXACT [EC:4.4.1.19]
xref: EC:4.4.1.19
xref: MetaCyc:4.4.1.19-RXN
xref: MetaCyc:R228-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0043818
name: precorrin-3B synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: precorrin-3A + NADH + H+ + O2 = precorrin-3B + NAD+ + H2O." [IMG:01805]
subset: gosubset_prok
synonym: "CobG" RELATED []
synonym: "precorrin-3A,NADH:oxygen oxidoreductase (20-hydroxylating)" EXACT []
synonym: "precorrin-3X synthase activity" EXACT [EC:1.14.13.83]
xref: EC:1.14.13.83
xref: MetaCyc:R321-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0043819
name: precorrin-6A synthase (deacetylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-5 + H2O = S-adenosyl-L-homocysteine + precorrin-6A + acetate." [EC:2.1.1.152, IMG:01802]
subset: gosubset_prok
synonym: "CobF" RELATED []
synonym: "precorrin-6X synthase (deacetylating) activity" EXACT [EC:2.1.1.152]
synonym: "S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating)" EXACT []
xref: EC:2.1.1.152
xref: MetaCyc:R322-RXN
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043820
name: propionyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA." [PMID:12603323]
subset: gosubset_prok
xref: EC:1.3.99.-
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0043821
name: propionyl-CoA:succinate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate." [IMG:01589, MetaCyc:RXN0-268]
subset: gosubset_prok
synonym: "propionyl-CoA succinate CoA-transferase activity" EXACT []
synonym: "propionyl-CoA:succinate CoA transferase activity" EXACT []
xref: EC:2.8.3.-
xref: MetaCyc:RXN0-268
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0043822
name: ribonuclease M5 activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor." [EC:3.1.26.8, IMG:02522]
subset: gosubset_prok
synonym: "5S ribosomal maturation nuclease activity" EXACT [EC:3.1.26.8]
synonym: "5S ribosomal RNA maturation endonuclease activity" EXACT []
synonym: "RNase M5 activity" EXACT [EC:3.1.26.8]
xref: EC:3.1.26.8
xref: MetaCyc:3.1.26.8-RXN
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0043823
name: spheroidene monooxygenase activity
namespace: molecular_function
def: "Catalysis of the conversion of spheroidene to spheroidenone." [IMG:01761, PMID:16086104, PMID:16158287]
subset: gosubset_prok
xref: EC:1.14.-.-
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0043824
name: succinylglutamate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH + 2 H+." [EC:1.2.1.71, IMG:00484]
subset: gosubset_prok
synonym: "AruD" RELATED []
synonym: "AstD" RELATED []
synonym: "N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.71]
synonym: "N-succinylglutamate 5-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.71]
synonym: "SGSD" RELATED []
synonym: "succinyl glutamate-semialdehyde dehydrogenase activity" EXACT []
synonym: "succinylglutamic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.71]
xref: EC:1.2.1.71
xref: MetaCyc:SUCCGLUALDDEHYD-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043825
name: succinylornithine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.81, IMG:00483]
subset: gosubset_prok
synonym: "2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.81]
synonym: "AstC" RELATED []
synonym: "N(2)-succinylornithine 5-aminotransferase activity" EXACT [EC:2.6.1.81]
synonym: "N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT []
synonym: "N2-succinylornithine 5-aminotransferase activity" EXACT []
synonym: "SOAT" RELATED []
synonym: "succinyl ornithine transaminase activity" EXACT []
synonym: "succinyl-ornithine transaminase activity" EXACT [EC:2.6.1.81]
synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.81]
xref: EC:2.6.1.81
xref: MetaCyc:SUCCORNTRANSAM-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0043826
name: sulfur oxygenase reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5 S0 + oxygen + 4 H2O = sulfite + thiosulfate + 2 hydrogen sulfide." [IMG:00713, MetaCyc:RXN-8226, PMID:1522063]
subset: gosubset_prok
synonym: "SOR" RELATED []
synonym: "sulphur oxygenase reductase activity" EXACT []
xref: EC:1.-.-.-
xref: MetaCyc:RXN-8226
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043827
name: tRNA (adenine-57, 58-N(1)-) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the methylation of adenine-57 and adenine-58 in the T-loop of tRNA." [IMG:00706, PMID:14739239]
subset: gosubset_prok
synonym: "TrmI" RELATED []
synonym: "tRNA (adenine-57, 58 N1-) methyltransferase activity" EXACT []
synonym: "tRNA (adenine-57, 58-N1-) methyltransferase activity" EXACT []
synonym: "tRNA (m1A) MTase" BROAD []
xref: EC:2.1.1.-
is_a: GO:0016429 ! tRNA (adenine-N1-)-methyltransferase activity

[Term]
id: GO:0043828
name: tRNA 2-selenouridine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA)." [IMG:02609, MetaCyc:RXN0-2281]
subset: gosubset_prok
synonym: "B0503" RELATED []
synonym: "SelU" RELATED []
synonym: "YbbB" RELATED []
xref: EC:2.9.1.-
xref: MetaCyc:RXN0-2281
is_a: GO:0016786 ! selenotransferase activity

[Term]
id: GO:0043829
name: tRNA-specific adenosine-37 deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule." [IMG:00703, PMID:8915538, PMID:9707437]
subset: gosubset_prok
synonym: "TAD1" RELATED []
synonym: "tRNA(Ala)-A37 deaminase activity" EXACT []
synonym: "tRNA-specific adenosine deaminase 1" EXACT []
xref: EC:3.5.4.-
is_a: GO:0008251 ! tRNA-specific adenosine deaminase activity

[Term]
id: GO:0043830
name: thiol-driven fumarate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: fumarate + coenzyme M + coenzyme B = succinate + coenzyme M + coenzyme B + heterodisulfide." [IMG:01366, PMID:2509466]
subset: gosubset_prok
xref: EC:1.3.99.-
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0043831
name: thiosulfate dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 thiosulfate + 2 6-decylubiquinone = tetrathionate + 2 6-decylubiquinol." [EC:1.8.5.2, IMG:00714, MetaCyc:1.8.5.2-RXN]
subset: gosubset_prok
synonym: "DoxA" RELATED []
synonym: "DoxD" RELATED []
synonym: "thiosulfate oxidoreductase, tetrathionate-forming activity" EXACT [EC:1.8.5.2]
synonym: "thiosulfate:6-decylubiquinone oxidoreductase activity" EXACT [EC:1.8.5.2]
synonym: "thiosulfate:quinone oxidoreductase activity" EXACT [EC:1.8.5.2]
synonym: "thiosulphate dehydrogenase (quinone) activity" EXACT []
synonym: "thiosulphate:quinone oxidoreductase activity" EXACT []
synonym: "TQO" RELATED []
xref: EC:1.8.5.2
xref: MetaCyc:1.8.5.2-RXN
is_a: GO:0016672 ! oxidoreductase activity, acting on sulfur group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0043832
name: trans-2, cis-3 decenoyl-ACP isomerase activity
namespace: molecular_function
def: "Catalysis of the isomerization of trans-2-decenoyl-ACP to cis-3-decenoyl-ACP." [IMG:02508, PMID:12237320]
subset: gosubset_prok
synonym: "trans-2, cis-3 decenoyl-[acyl-carrier-protein] isomerase activity" EXACT []
xref: EC:5.3.3.-
xref: MetaCyc:5.3.3.14-RXN
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0043833
name: methylamine-specific methylcobalamin:coenzyme M methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M." [IMG:01318, MetaCyc:RXN-8099]
comment: This function is the second step in the pathway of methanogenesis from monomethylamine, dimethylamine and trimethylamine.
subset: gosubset_prok
synonym: "dimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW []
synonym: "methylamine-specific methylcobalamin:CoM methyltransferase activity" EXACT []
synonym: "methylcobamide:coenzyme M methyltransferase activity" EXACT []
synonym: "methylcobamide:CoM methyltransferase activity" EXACT []
synonym: "methylcobamide:CoM methyltransferase II isozyme A" RELATED []
synonym: "monomethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW []
synonym: "MT2" BROAD []
synonym: "MT2-A" RELATED []
synonym: "MtbA" RELATED []
synonym: "trimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8099
xref: MetaCyc:RXN-8101
xref: MetaCyc:RXN-8103
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043834
name: trimethylamine methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine." [IMG:01323, MetaCyc:RXN-8102]
comment: This function is the first step in the pathway of methanogenesis from trimethylamine.
subset: gosubset_prok
synonym: "MT1" BROAD []
synonym: "mttB1" RELATED []
synonym: "TMA methyltransferase 1" EXACT []
synonym: "trimethylamine:corrinoid methyltransferase activity" EXACT []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8102
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043835
name: uracil/thymine dehydrogenase activity
namespace: molecular_function
def: "Catalyzes the reactions: (1) uracil + H2O + acceptor = barbiturate + reduced acceptor (2) thymine + H2O + acceptor = 5-methylbarbiturate + reduced acceptor." [EC:1.17.99.4, IMG:01821]
subset: gosubset_prok
synonym: "uracil oxidase activity" RELATED [EC:1.17.99.4]
synonym: "uracil-thymine oxidase activity" EXACT [EC:1.17.99.4]
synonym: "uracil:acceptor oxidoreductase activity" EXACT []
xref: EC:1.17.99.4
is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups

[Term]
id: GO:0043836
name: xanthine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate." [IMG:01834, MetaCyc:R127-RXN]
subset: gosubset_prok
synonym: "xanthinase activity" EXACT []
xref: EC:3.5.2.-
xref: MetaCyc:R127-RXN
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0043837
name: valine dehydrogenase (NAD) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-valine + H(2)O + NAD(+) = 3-methyl-2-oxobutanoate + NH(3) + NADH." [IMG:00766, PMID:10612726, PMID:2803248]
subset: gosubset_prok
synonym: "ValDH" RELATED []
xref: EC:1.4.1.-
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043838
name: phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol." [IMG:00182, PMID:15795227]
comment: Note that Kdo is an abbreviation for 3-deoxy-D-manno-oct-2-ulosonic acid.
subset: gosubset_prok
synonym: "EptB" RELATED []
synonym: "phosphoethanolamine transferase" BROAD []
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0043839
name: lipid A phosphate methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate moiety of lipid A." [IMG:02094, PMID:15994324]
subset: gosubset_prok
synonym: "lipid A 1-phosphomethyltransferase activity" EXACT []
synonym: "lipid A methyltransferase" BROAD []
synonym: "lipid A phosphomethyltransferase activity" EXACT []
synonym: "LmtA" RELATED []
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0043840
name: branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine." [IMG:01684, PMID:12670965]
subset: gosubset_prok
synonym: "BCAT" RELATED []
synonym: "branched chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity" EXACT []
synonym: "branched-chain amino acid aminotransferase" BROAD []
synonym: "branched-chain-amino-acid:2-keto-4-methylthiobutyrate aminotransferase activity" EXACT []
xref: EC:2.6.1.-
xref: MetaCyc:RXN-7708
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0043841
name: (S)-lactate 2-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate + GTP = 2-phospho-(S)-lactate + GDP." [IMG:01546, PMID:11535063]
subset: gosubset_prok
synonym: "lactate 2-kinase activity" EXACT []
xref: EC:2.7.1.-
xref: IMG:01546
xref: MetaCyc:RXN-8076
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043842
name: Kdo transferase activity
namespace: molecular_function
def: "Catalysis of the reactions: (1) (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP (2) lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP." [IMG:00549, PMID:1577828, PMID:2033061, PMID:9195966]
subset: gosubset_prok
synonym: "3-deoxy-D-manno-octulosonic-acid transferase activity" EXACT []
synonym: "kdtA" RELATED []
synonym: "WaaA" RELATED []
xref: EC:2.-.-.-
xref: MetaCyc:KDOTRANS-RXN
xref: MetaCyc:KDOTRANS2-RXN
is_a: GO:0016740 ! transferase activity

[Term]
id: GO:0043843
name: ADP-specific glucokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate." [EC:2.7.1.147, IMG:01468]
subset: gosubset_prok
synonym: "ADP-dependent glucokinase activity" EXACT [EC:2.7.1.147]
synonym: "ADP:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.147]
xref: EC:2.7.1.147
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043844
name: ADP-specific phosphofructokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate." [EC:2.7.1.146, IMG:01469]
subset: gosubset_prok
synonym: "ADP-6-phosphofructokinase activity" EXACT [EC:2.7.1.146]
synonym: "ADP-dependent phosphofructokinase activity" EXACT [EC:2.7.1.146]
synonym: "ADP-Pfk activity" EXACT [EC:2.7.1.146]
synonym: "ADP:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.146]
xref: EC:2.7.1.146
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043845
name: DNA polymerase III, proofreading complex
namespace: cellular_component
def: "A subcomplex of DNA polymerase III composed of the epsilon subunit which has proofreading activity, and the theta subunit which enhances the epsilon subunit's proofreading activity." [IMG:01721, Wikipedia:Pol_III]
subset: gosubset_prok
synonym: "DNA polymerase III, proof-reading complex" EXACT []
synonym: "DNA polymerase III, proof-reading subcomplex" EXACT []
synonym: "DNA polymerase III, proofreading subcomplex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0009360 ! DNA polymerase III complex

[Term]
id: GO:0043846
name: DNA polymerase III, DnaX complex
namespace: cellular_component
def: "A heptamer that includes the tau and gamma products of the dnaX gene and the chi/psi subcomplex. Confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands." [PMID:12940977]
subset: gosubset_prok
synonym: "clamp loader complex" BROAD []
synonym: "DNA polymerase III, clamp loader complex" EXACT []
synonym: "DNA polymerase III, DnaX subcomplex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0009360 ! DNA polymerase III complex

[Term]
id: GO:0043847
name: DNA polymerase III, DnaX complex, chi/psi subcomplex
namespace: cellular_component
def: "A dimer composed of the chi and psi subunits which is a subassembly of the DNA polymerase III DnaX complex and serves as a bridge between the DnaX complex and the single-stranded DNA-binding protein (SSB)." [IMG:01719, PMID:12940977]
subset: gosubset_prok
synonym: "DNA polymerase III, clamp loader chi/psi subcomplex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0043846 ! DNA polymerase III, DnaX complex

[Term]
id: GO:0043848
name: excinuclease cho activity
namespace: molecular_function
def: "Catalysis of the incision of damaged DNA on the 3' side of a lesion, typically at the ninth phosphodiester bond 3' of the damage." [IMG:00499, PMID:11818552]
comment: Note that this function occurs as part of nucleotide excision repair (NER).
subset: gosubset_prok
synonym: "cho" RELATED []
synonym: "endonuclease cho" EXACT []
synonym: "uvrc homolog protein" RELATED []
is_a: GO:0016890 ! site-specific endodeoxyribonuclease activity, specific for altered base

[Term]
id: GO:0043849
name: Ras palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins." [IMG:00473, PMID:16000296]
subset: gosubset_prok
synonym: "DHHC cysteine-rich domain-containing protein ERF2" RELATED []
synonym: "ERF2" RELATED []
synonym: "palmitoyltransferase ERF2" RELATED []
synonym: "Ras protein acyltransferase activity" EXACT []
xref: EC:2.3.1.-
is_a: GO:0016409 ! palmitoyltransferase activity

[Term]
id: GO:0043850
name: RecFOR complex
namespace: cellular_component
def: "A heterotrimeric complex composed of the subunits RecF, RecO and RecR. Mediates the loading of RecA protein specifically onto SSB-coated gapped DNA during DNA repair." [IMG:01764, PMID:12769856]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part

[Term]
id: GO:0043851
name: methanol-specific methylcobalamin:coenzyme M methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of the methyl group from the methylated corrinoid cofactor of a methanol corrinoid protein to coenzyme M." [IMG:01315, MetaCyc:RXN-8096]
comment: This function is the second step in the pathway of methanogenesis from methanol.
subset: gosubset_prok
synonym: "methanol-specific methylcobalamin: coenzyme M methyltransferase activity" EXACT []
synonym: "methanol-specific methylcobalamin:CoM methyltransferase activity" EXACT []
synonym: "methyltransferase 2" BROAD []
synonym: "MT2" BROAD []
synonym: "MtaA" RELATED []
synonym: "MtaC protein: coenzyme M methyltransferase activity" EXACT []
synonym: "MtaC protein:coenzyme M methyltransferase activity" EXACT []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8096
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043852
name: monomethylamine methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + ammonia." [IMG:01319, MetaCyc:RXN-8098]
comment: This function is the first step in the pathway of methanogenesis from monomethylamine.
subset: gosubset_prok
synonym: "MMAMT" RELATED []
synonym: "monomethylamine:corrinoid methyltransferase activity" EXACT []
synonym: "MtmB" RELATED []
xref: EC:2.1.1.-
xref: MetaCyc:RXN-8098
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0043853
name: methanol-CoM methyltransferase complex
namespace: cellular_component
def: "A heterotrimeric protein complex composed of a methanol methyltransferase subunit, a corrinoid protein and a methanol-specific corrinoid:coenzyme M methyltransferase subunit. Catalyzes the transfer of a methyl group from methanol to coenzyme M as part of the pathway of methanogenesis from methanol." [IMG:01437, MetaCyc:CPLX-421, PMID:9363780]
subset: gosubset_prok
synonym: "methanol-coenzyme M methyltransferase complex" EXACT []
synonym: "methanol: coenzyme M methyltransferase complex" EXACT []
synonym: "methanol: CoM methyltransferase complex" EXACT []
synonym: "methanol:coenzyme M methyltransferase complex" EXACT []
synonym: "methanol:CoM methyltransferase complex" EXACT []
xref: MetaCyc:CPLX-421
is_a: GO:0034708 ! methyltransferase complex

[Term]
id: GO:0043854
name: cyclic nucleotide-gated mechanosensitive ion channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress and when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl, IMG:02416]
subset: gosubset_prok
synonym: "cyclic nucleotide gated mechanosensitive ion channel activity" EXACT []
synonym: "cyclic nucleotide regulated mechanosensitive ion channel" EXACT []
synonym: "cyclic nucleotide-regulated mechanosensitive ion channel" EXACT []
synonym: "cyclic nucleotide-regulated small mechanosensitive ion channel" RELATED []
synonym: "MscS" RELATED []
synonym: "small conductance mechanosensitive ion channel" EXACT []
is_a: GO:0008381 ! mechanically-gated ion channel activity
is_a: GO:0043855 ! cyclic nucleotide-gated ion channel activity

[Term]
id: GO:0043855
name: cyclic nucleotide-gated ion channel activity
namespace: molecular_function
def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl]
subset: gosubset_prok
synonym: "cyclic nucleotide activated ion channel activity" EXACT []
synonym: "cyclic nucleotide gated ion channel activity" EXACT []
synonym: "cyclic nucleotide-activated ion channel activity" EXACT []
is_a: GO:0015276 ! ligand-gated ion channel activity

[Term]
id: GO:0043856
name: anti-sigma factor antagonist activity
namespace: molecular_function
def: "The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity." [GOC:jl, PMID:15576799]
subset: gosubset_prok
synonym: "anti-anti-sigma factor activity" EXACT []
is_a: GO:0030528 ! transcription regulator activity

[Term]
id: GO:0043857
name: N-acetylornithine carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbamoyl phosphate + N2-acetyl-L-ornithine = phosphate + N-acetyl-L-citrulline." [EC:2.1.3.9]
subset: gosubset_prok
synonym: "acetylornithine transcarbamylase activity" EXACT []
synonym: "AOTC" RELATED []
synonym: "carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.9]
synonym: "carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.9]
synonym: "N-acetylornithine transcarbamylase activity" EXACT []
xref: EC:2.1.3.9
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0043858
name: arginine:ornithine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out)." [GOC:jl, PMID:17110979]
subset: gosubset_prok
synonym: "ArcD" RELATED []
synonym: "arginine-ornithine antiporter activity" EXACT []
synonym: "arginine/ornithine antiporter activity" EXACT []
is_a: GO:0015300 ! solute:solute antiporter activity

[Term]
id: GO:0043859
name: cyanophycinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides." [PMID:10429200]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
xref: EC:3.-.-.-
is_obsolete: true
replaced_by: GO:0008236

[Term]
id: GO:0043860
name: cyanophycin synthetase activity
namespace: molecular_function
def: "Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer)." [EC:6.3.2.29, EC:6.3.2.30, GOC:jl]
subset: gosubset_prok
synonym: "cphA" RELATED []
xref: EC:6.3.1.-
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0043861
name: agmatine:putrescine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out)." [GOC:jl, PMID:17028272]
subset: gosubset_prok
synonym: "agmatine-putrescine antiporter activity" EXACT []
synonym: "agmatine/putrescine antiporter activity" EXACT []
is_a: GO:0015300 ! solute:solute antiporter activity

[Term]
id: GO:0043862
name: arginine:agmatine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: arginine(out) + agmatine(in) = arginine(in) + agmatine(out)." [GOC:jl, PMID:17099215]
subset: gosubset_prok
synonym: "AdiC" RELATED []
synonym: "arginine-agmatine antiporter activity" EXACT []
synonym: "arginine-agmatine exchange transporter activity" EXACT []
synonym: "arginine/agmatine antiporter activity" EXACT []
is_a: GO:0015300 ! solute:solute antiporter activity

[Term]
id: GO:0043863
name: 4-hydroxy-2-ketopimelate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate." [MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN]
subset: gosubset_prok
synonym: "2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase activity" EXACT []
synonym: "HHED aldolase activity" EXACT []
synonym: "HpaI" RELATED []
synonym: "HpcH" RELATED []
xref: EC:4.1.2.-
xref: MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0043864
name: indoleacetamide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetamide (IAM) + H2O = indole-3-acetate (IAA) + NH3." [GOC:jl, MetaCyc:RXNN-404]
subset: gosubset_prok
synonym: "IaaH" RELATED []
synonym: "IAH" EXACT []
synonym: "indole acetamide hydrolase activity" EXACT []
synonym: "indole-3-acetamide hydrolase activity" EXACT []
synonym: "Tms2" RELATED []
xref: EC:3.5.1.-
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0043865
name: methionine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of methionine from one side of a membrane to the other." [GOC:jl]
subset: gosubset_prok
is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity

[Term]
id: GO:0043866
name: adenylyl-sulfate reductase (thioredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin." [EC:1.8.4.10]
subset: gosubset_prok
synonym: "AMP, sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT []
synonym: "AMP,sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.10]
synonym: "thioredoxin-dependent 5'-adenylylsulfate reductase activity" EXACT []
xref: EC:1.8.4.10
is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0043867
name: 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA guanine + 7-cyano-7-deazaguanine = tRNA 7-cyano-7-deazaguanine + guanine." [PMID:16407303, PMID:7748953]
subset: gosubset_prok
synonym: "archaeal tRNA-guanine transglycosylase activity" EXACT []
synonym: "archaeosine tRNA-ribosyltransferase activity" EXACT []
synonym: "TgtA" RELATED []
xref: EC:2.4.2.-
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0043868
name: N-acetylaminoadipate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate." [PMID:10613839]
subset: gosubset_prok
synonym: "acetylaminoadipate kinase activity" EXACT []
synonym: "LysZ" RELATED []
synonym: "N-acetyl-L-aminoadipate 5-phosphotransferase activity" EXACT []
xref: EC:2.7.2.-
xref: MetaCyc:RXN-5182
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0043869
name: alpha-aminoadipate acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-aminoadipate + acetyl-CoA = N2-acetyl-alpha-aminoadipate + coenzyme A." [MetaCyc:RXN-5181, PMID:10613839, PMID:12925802]
subset: gosubset_prok
synonym: "lysine biosynthesis protein" RELATED []
synonym: "LysX" RELATED []
synonym: "RimK" RELATED []
xref: MetaCyc:RXN-5181
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0043870
name: N-acetyl-gamma-aminoadipyl-phosphate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP(+) + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH." [MetaCyc:RXN-5183]
comment: This function is part of the prokaryotic alpha-aminoadipate lysine biosynthesis pathway.
subset: gosubset_prok
synonym: "AGPR" RELATED []
synonym: "ArgC" RELATED []
synonym: "LysY" RELATED []
synonym: "N-acetyl-alpha-glutamyl-phosphate reductase activity" EXACT []
synonym: "N-acetyl-aminoadipate semialdehyde dehydrogenase activity" EXACT []
synonym: "NAGSA dehydrogenase activity" BROAD []
xref: EC:1.2.1.-
xref: MetaCyc:RXN-5183
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043871
name: delta1-piperideine-6-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-pipecolate = delta1-piperideine-6-carboxylate + 2 H+." [MetaCyc:RXN-8161, PMID:16237033]
comment: This function is part of the pipecolate pathway of lysine catabolism.
subset: gosubset_prok
synonym: "AmaB" RELATED []
synonym: "delta 1-piperideine-6-carboxylate dehydrogenase activity" EXACT []
synonym: "delta-1-piperideine-6-carboxylate dehydrogenase activity" EXACT []
synonym: "PIPOX" RELATED []
xref: MetaCyc:RXN-8161
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043872
name: lysine:cadaverine antiporter activity
namespace: molecular_function
alt_id: GO:0015497
def: "Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out)." [GOC:jl, PMID:10986235, TC:2.A.3.2.2]
subset: gosubset_prok
synonym: "cadaverine:lysine antiporter activity" EXACT []
synonym: "CadB" RELATED []
synonym: "lysine-cadaverine antiporter activity" EXACT []
synonym: "lysine/cadaverine antiporter activity" EXACT []
is_a: GO:0015189 ! L-lysine transmembrane transporter activity
is_a: GO:0015300 ! solute:solute antiporter activity
is_a: GO:0015490 ! cadaverine transmembrane transporter activity

[Term]
id: GO:0043873
name: pyruvate-flavodoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin." [PMID:6352705]
subset: gosubset_prok
synonym: "NifJ" RELATED []
synonym: "pyruvate:flavodoxin oxidoreductase activity" EXACT []
xref: EC:1.2.7.-
xref: MetaCyc:PYFLAVOXRE-RXN
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0043874
name: acireductone synthase activity
namespace: molecular_function
def: "Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate." [EC:3.1.3.77]
comment: This function is involved in the process of methionine salvage.
subset: gosubset_prok
synonym: "5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)" EXACT [EC:3.1.3.77]
synonym: "E-1" RELATED []
synonym: "E-1 enolase-phosphatase" BROAD []
xref: EC:3.1.3.77
xref: MetaCyc:3.1.3.77-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0043875
name: 2-ketobutyrate formate-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxobutanoate + coenzyme A = propionyl-CoA + formate." [MetaCyc:KETOBUTFORMLY-RXN, PMID:9484901]
comment: This function is part of an anaerobic pathway for the catabolism of L-threonine.
subset: gosubset_prok
synonym: "keto-acid formate acetyltransferase" BROAD []
synonym: "KFL" EXACT []
synonym: "TdcE" RELATED []
xref: EC:2.3.1-
xref: MetaCyc:KETOBUTFORMLY-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0043876
name: D-threonine aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde." [MetaCyc:4.1.2.42-RXN, PMID:9642221]
subset: gosubset_prok
synonym: "D-allo-TA" EXACT []
synonym: "D-allo-threonine aldolase activity" EXACT []
synonym: "D-TA" EXACT []
synonym: "DtaAS" RELATED []
synonym: "low-specificity D-threonine aldolase" NARROW []
xref: EC:4.1.2.-
xref: MetaCyc:4.1.2.42-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0043877
name: galactosamine-6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3." [PMID:10931310]
comment: This function is part of the pathway of N-acetyl-galactosamine and galactosamine utilization.
subset: gosubset_prok
synonym: "AgaI" RELATED []
synonym: "galactosamine-6-phosphate deaminase activity" EXACT []
xref: EC:5.3.1.-
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0043878
name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+." [PMID:9497334]
subset: gosubset_prok
synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD) (non-phosphorylating) activity" EXACT []
synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD) activity" EXACT []
synonym: "NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT []
synonym: "non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NAD)" EXACT []
xref: EC:1.2.1.-
xref: MetaCyc:RXN-3443
is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity

[Term]
id: GO:0043879
name: glycolate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA)." [ChEBI:28905, GOC:jl]
subset: gosubset_prok
synonym: "glcA" RELATED []
synonym: "glycolate permease" RELATED []
synonym: "glycolic acid transmembrane transporter activity" EXACT []
synonym: "hydroxyacetic acid transmembrane transporter activity" EXACT []
is_a: GO:0008514 ! organic anion transmembrane transporter activity

[Term]
id: GO:0043880
name: crotonyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reduction of crotonyl-CoA to butyryl-CoA." [IPR:IPR010085, PMID:11162231]
subset: gosubset_prok
synonym: "CCR" EXACT []
synonym: "crotonyl-coenzyme A reductase activity" EXACT []
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043881
name: mesaconyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA." [PMID:16856935, PMID:16856937]
comment: This function is part of an alternate glyoxylate cycle for acetate assimilation.
subset: gosubset_prok
synonym: "beta-methylmalyl-CoA dehydratase activity" EXACT []
synonym: "mch" RELATED []
synonym: "mesaconyl-coenzyme A hydratase activity" EXACT []
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043882
name: malate:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + Na+(out) = malate(in) + Na+(in)." [GOC:jl, PMID:10903309]
subset: gosubset_prok
synonym: "malate Na(+) symporter activity" EXACT []
synonym: "malate-sodium symporter activity" EXACT []
synonym: "malate/sodium cotransporter activity" BROAD []
synonym: "malate/sodium symporter activity" EXACT []
synonym: "malate:Na+ symporter activity" EXACT []
synonym: "malate:sodium cotransporter activity" BROAD []
synonym: "Na(+)-malate symporter activity" EXACT []
synonym: "Na+:malate symporter activity" EXACT []
synonym: "sodium-dependent malate transporter" BROAD []
synonym: "sodium/malate symporter activity" EXACT []
synonym: "sodium:malate symporter activity" EXACT []
is_a: GO:0015140 ! malate transmembrane transporter activity
is_a: GO:0015296 ! anion:cation symporter activity

[Term]
id: GO:0043883
name: malolactic enzyme activity
namespace: molecular_function
def: "Catalysis of the reaction: malate + H+ = L-lactate + CO2." [MetaCyc:RXN8E-5623, PMID:3139053]
comment: This function is part of the process of degradation of L-malic acid by lactic acid bacteria.
subset: gosubset_prok
synonym: "MleS" RELATED []
xref: EC:1.-.-.-
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043884
name: CO-methylating acetyl-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA." [EC:2.3.1.169, PMID:1748656]
subset: gosubset_prok
synonym: "acetyl-CoA synthase activity" BROAD []
synonym: "acetyl-CoA:corrinoid protein O-acetyltransferase activity" EXACT []
synonym: "ACS" RELATED [EC:2.3.1.169]
synonym: "CO-methylating acetyl-coenzyme A synthase activity" EXACT []
xref: EC:2.3.1.169
xref: MetaCyc:ACETYLSYNCLTH-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0043885
name: carbon-monoxide dehydrogenase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin." [EC:1.2.7.4]
subset: gosubset_prok
synonym: "carbon monoxide dehydrogenase (ferredoxin) activity" EXACT []
synonym: "carbon monoxide dehydrogenase activity" BROAD []
synonym: "carbon-monoxide dehydrogenase activity" BROAD [EC:1.2.7.4]
synonym: "carbon-monoxide,water:ferredoxin oxidoreductase activity" EXACT []
synonym: "carbon-monoxide:(acceptor) oxidoreductase activity" EXACT []
synonym: "CO dehydrogenase activity" EXACT []
synonym: "CO-dehydrogenase (ferredoxin) activity" EXACT []
synonym: "CO-dehydrogenase activity" EXACT []
synonym: "CODH" RELATED []
xref: EC:1.2.7.4
xref: MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0043886
name: structural constituent of carboxysome
namespace: molecular_function
def: "The action of a molecule that contributes to the structural integrity of a carboxysome, an organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide." [GOC:jl]
subset: gosubset_prok
is_a: GO:0005198 ! structural molecule activity

[Term]
id: GO:0043887
name: melibiose:sodium symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in)." [PMID:1970646]
subset: gosubset_prok
synonym: "MelB" RELATED []
synonym: "melibiose carrier protein" RELATED []
synonym: "melibiose permease" BROAD []
synonym: "melibiose-Na+ symporter activity" EXACT []
synonym: "melibiose-sodium symporter activity" EXACT []
synonym: "melibiose/Na+ symporter activity" EXACT []
synonym: "melibiose/sodium symporter activity" EXACT []
synonym: "melibiose:Na+ symporter activity" EXACT []
synonym: "Na+ (Li+)/melibiose symporter activity" EXACT []
synonym: "Na+-melibiose symporter activity" EXACT []
synonym: "Na+/melibiose symporter activity" EXACT []
synonym: "Na+:melibiose symporter activity" EXACT []
synonym: "sodium-melibiose symporter activity" EXACT []
synonym: "sodium/melibiose symporter activity" EXACT []
synonym: "sodium:melibiose symporter activity" EXACT []
synonym: "thiomethylgalactoside permease II" RELATED []
is_a: GO:0015487 ! melibiose:monovalent cation symporter activity

[Term]
id: GO:0043888
name: (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the transfer of a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate." [PMID:15356000, PMID:16494480]
comment: This function is involved in archaeal lipid synthesis.
subset: gosubset_prok
synonym: "2,3-dGGGPS" EXACT []
synonym: "DGGGP synthase activity" EXACT []
synonym: "DGGGPS" EXACT []
synonym: "UbiA" RELATED []
xref: EC:2.5.1.-
is_a: GO:0002094 ! polyprenyltransferase activity
is_a: GO:0004337 ! geranyltranstransferase activity

[Term]
id: GO:0043889
name: (S)-3-O-geranylgeranylglyceryl phosphate activity
namespace: molecular_function
def: "Catalysis of the alkylation of the primary hydroxyl group in (S)-glyceryl phosphate by geranylgeranyl diphosphate to form (S)-3-O-geranylgeranylglyceryl phosphate." [PMID:12801917, PMID:17253090, PMID:8408023]
comment: This function is involved in archaeal lipid synthesis.
subset: gosubset_prok
synonym: "(S)-3-O-geranylgeranylglycerylphosphate activity" EXACT []
synonym: "(S)-GGGP synthase activity" EXACT []
synonym: "GGGP synthase activity" EXACT []
synonym: "GGGPS" EXACT []
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0043890
name: N-acetylgalactosamine-6-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate." [EC:3.1.6.4]
subset: gosubset_prok
synonym: "acetylgalactosamine 6-sulfatase activity" EXACT []
synonym: "chondroitin sulfatase" BROAD []
synonym: "chondroitinase" BROAD []
synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.4]
synonym: "galactose-6-sulfate sulfatase activity" EXACT []
synonym: "N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity" EXACT []
synonym: "N-acetylgalactosamine 6-sulfatase activity" EXACT []
synonym: "N-acetylgalactosamine-6-sulfate sulfatase activity" EXACT []
xref: EC:3.1.6.4
xref: MetaCyc:3.1.6.4-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0043891
name: glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+." [EC:1.2.1.59]
subset: gosubset_prok
synonym: "D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating)" EXACT []
synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)" EXACT []
synonym: "NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.59]
synonym: "triosephosphate dehydrogenase (NAD(P))" EXACT []
synonym: "triosephosphate dehydrogenase (NAD(P)+)" EXACT [EC:1.2.1.59]
xref: EC:1.2.1.59
xref: MetaCyc:GAPDHSYNEC-RXN
is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity

[Term]
id: GO:0043892
name: methylglyoxal reductase (NADPH-dependent) activity
namespace: molecular_function
def: "Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+." [EC:1.1.1.283]
subset: gosubset_prok
synonym: "Gre2" RELATED []
synonym: "lactaldehyde dehydrogenase (NADP+)" EXACT []
synonym: "lactaldehyde:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.283]
xref: EC:1.1.1.283
xref: MetaCyc:1.1.1.283-RXN
xref: MetaCyc:RXN-8636
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043893
name: acetate:cation symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of acetate from one side of a membrane to the other according to the reaction: acetate(out) + cation(out) = acetate(in) + cation(in)." [GOC:jl]
subset: gosubset_prok
synonym: "acetate permease" BROAD []
synonym: "acetate-cation symporter activity" EXACT []
synonym: "acetate/cation symporter activity" EXACT []
synonym: "ActP" RELATED []
synonym: "cation-acetate symporter activity" EXACT []
synonym: "cation/acetate symporter activity" EXACT []
synonym: "cation:acetate symporter activity" EXACT []
is_a: GO:0015294 ! solute:cation symporter activity

[Term]
id: GO:0043894
name: acetyl-CoA synthetase acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate." [PMID:15236963]
subset: gosubset_prok
synonym: "Pat" RELATED []
synonym: "Pat enzyme" EXACT []
synonym: "protein acetyltransferase activity" BROAD []
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0043895
name: cyclomaltodextrin glucanotransferase activity
namespace: molecular_function
def: "Catalysis of the cyclization of part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond." [EC:2.4.1.19]
synonym: "1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (cyclizing)" EXACT []
synonym: "alpha-1,4-glucan 4-glycosyltransferase, cyclizing" RELATED []
synonym: "alpha-cyclodextrin glucanotransferase" RELATED []
synonym: "alpha-cyclodextrin glycosyltransferase" RELATED []
synonym: "Bacillus macerans amylase" RELATED []
synonym: "beta-cyclodextrin glucanotransferase" RELATED []
synonym: "beta-cyclodextrin glycosyltransferase" RELATED []
synonym: "BMA" RELATED []
synonym: "CGTase" RELATED []
synonym: "cyclodextrin glucanotransferase" BROAD []
synonym: "cyclodextrin glycosyltransferase" RELATED []
synonym: "cyclomaltodextrin glucotransferase" RELATED []
synonym: "cyclomaltodextrin glycosyltransferase" RELATED []
synonym: "gamma-cyclodextrin glycosyltransferase" RELATED []
synonym: "konchizaimu" RELATED []
synonym: "neutral-cyclodextrin glycosyltransferase" RELATED []
xref: EC:2.4.1.19
xref: MetaCyc:2.4.1.19-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0043896
name: glucan 1,6-alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides." [EC:3.2.1.70]
subset: gosubset_prok
synonym: "exo-1,6-alpha-glucosidase activity" EXACT [EC:3.2.1.70]
synonym: "exo-1,6-beta-glucosidase" RELATED []
synonym: "glucan alpha-1,6-D-glucohydrolase activity" EXACT [EC:3.2.1.70]
synonym: "glucan-1,6-alpha-glucosidase activity" EXACT []
synonym: "glucodextranase activity" EXACT [EC:3.2.1.70]
synonym: "glucodextrinase" BROAD []
xref: EC:3.2.1.70
xref: MetaCyc:3.2.1.70-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0043897
name: glucan 1,4-alpha-maltohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains." [EC:3.2.1.133]
subset: gosubset_prok
synonym: "1,4-alpha-D-glucan alpha-maltohydrolase activity" EXACT []
synonym: "glucan-1,4-alpha-maltohydrolase activity" EXACT []
synonym: "maltogenic alpha-amylase activity" EXACT []
xref: EC:3.2.1.133
xref: MetaCyc:3.2.1.133-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0043898
name: 2,3-dihydroxybiphenyl 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxybiphenyl + O2 = 2-hydroxy-6-phenylhexa-2,4-dienoic acid." [GOC:jl, PMID:15715866]
subset: gosubset_prok
synonym: "2,3-dihydroxybiphenyl-1,2-dioxygenase activity" EXACT []
synonym: "BphC" RELATED []
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0043899
name: phosphoserine:homoserine phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine." [GOC:jl, PMID:14699121]
subset: gosubset_prok
synonym: "thrH" RELATED []
xref: EC:2.7.1.-
xref: IMG:02616
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043900
name: regulation of multi-organism process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a multi-organism process, a process by which an organism has an effect on another organism of the same or different species." [GOC:jl]
subset: gosubset_prok
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0051704 ! multi-organism process

[Term]
id: GO:0043901
name: negative regulation of multi-organism process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a multi-organism process, a process by which an organism has an effect on another organism of the same or different species." [GOC:jl]
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0051704 ! multi-organism process

[Term]
id: GO:0043902
name: positive regulation of multi-organism process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process by which an organism has an effect on another organism of the same or different species." [GOC:jl]
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0051704 ! multi-organism process

[Term]
id: GO:0043903
name: regulation of symbiosis, encompassing mutualism through parasitism
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association." [GOC:jl]
is_a: GO:0043900 ! regulation of multi-organism process
relationship: regulates GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0043904
name: isochorismate pyruvate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: isochorismate = salicylate + pyruvate." [GOC:jl, PMID:16248620]
subset: gosubset_prok
synonym: "IPL" EXACT []
synonym: "isochorismate-pyruvate lyase activity" EXACT []
xref: EC:4.1.3.-
xref: IMG:02661
xref: MetaCyc:RXN-1981
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0043905
name: Ser-tRNA(Thr) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Thr)." [GOC:jl, PMID:15240874]
subset: gosubset_prok
synonym: "Ser-tRNAThr hydrolase activity" EXACT []
xref: EC:3.1.1.-
xref: IMG:02667
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0043906
name: Ala-tRNA(Pro) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated Ala-tRNA(Pro)." [GOC:jl, PMID:14663147]
subset: gosubset_prok
synonym: "Ala-tRNAPro hydrolase activity" EXACT []
xref: EC:3.1.1.-
xref: IMG:02668
is_a: GO:0002161 ! aminoacyl-tRNA editing activity

[Term]
id: GO:0043907
name: Cys-tRNA(Pro) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated Cys-tRNA(Pro)." [GOC:jl, PMID:15886196]
subset: gosubset_prok
synonym: "Cys-tRNA(Pro) deacetylase activity" EXACT []
synonym: "Cys-tRNAPro hydrolase activity" EXACT []
xref: EC:3.1.1.-
xref: IMG:02669
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0043908
name: Ser(Gly)-tRNA(Ala) hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala) and Gly-tRNA(Ala)." [GOC:jl, PMID:14663147]
subset: gosubset_prok
synonym: "Ser(Gly)-tRNAAla hydrolase activity" EXACT []
xref: EC:3.1.1.-
xref: IMG:02670
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0043909
name: N-acetylcitrulline deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-L-citrulline + H2O => citrulline + acetate." [GOC:jl, IMG:02799, PMID:16750290]
subset: gosubset_prok
synonym: "acetylcitrulline deacetylase activity" EXACT []
synonym: "N-acetyl-L-citrulline deacetylase activity" EXACT []
xref: EC:3.5.1.-
xref: IMG:02799
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0043910
name: coenzyme F390 synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: coenzyme F420 + ATP = coenzyme F390." [GOC:jl, IMG:02803, PMID:7957247, PMID:8550473]
subset: gosubset_prok
synonym: "ATP:coenzyme F420 adenyltransferase activity" EXACT []
xref: EC:2.7.7.-
xref: IMG:02803
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0043911
name: D-lysine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate." [GOC:jl, IMG:02956, PMID:17259313]
subset: gosubset_prok
synonym: "D-lysine aminotransferase activity" EXACT []
xref: EC:2.6.1.-
xref: IMG:02956
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0043912
name: D-lysine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + H2O2." [GOC:jl, IMG:02957, PMID:17259313]
subset: gosubset_prok
xref: EC:1.4.3.-
xref: IMG:02957
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0043913
name: chromosome segregation-directing complex
namespace: cellular_component
def: "A trimeric protein complex which in E. coli is composed of the subunits MreB, MreC and MreD. The complex directs longitudinal cell wall synthesis, maintaining cell morphology." [GOC:jl, PMID:15612918]
subset: gosubset_prok
synonym: "chromosome segregation directing complex" EXACT []
synonym: "longitudinal peptidoglycan synthesis-directing complex" EXACT []
synonym: "MreBCD complex" NARROW []
xref: IMG:02994
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0043914
name: NADPH:sulfur oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + S0 = H2S + NADP." [GOC:jl, PMID:17449625]
subset: gosubset_prok
synonym: "CoA-dependent NAD(P)H sulfur oxidoreductase activity" EXACT []
synonym: "coenzyme A-dependent NAD(P)H sulfur oxidoreductase activity" EXACT []
synonym: "NAD(P)H elemental sulfur oxidoreductase activity" EXACT []
synonym: "NAD(P)H sulfur oxidoreductase activity" EXACT []
synonym: "NAD(P)H sulphur oxidoreductase activity" EXACT []
synonym: "NAD(P)H:sulfur oxidoreductase activity" EXACT []
synonym: "NADPH:sulphur oxidoreductase activity" EXACT []
synonym: "NSR" EXACT []
xref: EC:1.-.-.-
xref: IMG:03008
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0043915
name: L-seryl-tRNA(Sec) kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)." [GOC:jl, IMG:03019, PMID:16201757]
subset: gosubset_prok
synonym: "O-phosphoseryl-tRNA(Sec) kinase activity" EXACT []
xref: EC:2.7.1.-
xref: IMG:03019
xref: MetaCyc:RXN-10038
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0043916
name: DNA-7-methylguanine glycosylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of alkylated DNA; recognizes and removes the alkylated base 7-methylguanine." [GOC:jl, PMID:16468998]
subset: gosubset_prok
xref: EC:3.2.2.-
xref: IMG:03021
is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity

[Term]
id: GO:0043917
name: ribose 1,5-bisphosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate." [GOC:jl, IMG:03024]
subset: gosubset_prok
synonym: "ribose-1,5-bisphosphate isomerase activity" EXACT []
xref: EC:5.3.1.-
xref: IMG:03024
xref: MetaCyc:RXN-8801
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0043918
name: cadaverine aminopropyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosylmethioninamine + cadaverine = 5'-methylthioadenosine + N-(3-aminopropyl)cadaverine." [GOC:jl, IMG:00522, PMID:17545282]
subset: gosubset_prok
synonym: "cadaverine aminopropyl transferase activity" EXACT []
xref: EC:2.5.1.-
xref: IMG:00522
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0043919
name: agmatine aminopropyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: agmatine + S-adenosylmethioninamine = N1-aminopropylagmatine + 5'-methylthioadenosine." [GOC:jl, IMG:03077, PMID:15983049]
subset: gosubset_prok
synonym: "agmatine aminopropyl transferase activity" EXACT []
xref: EC:2.5.1.-
xref: IMG:03077
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0043920
name: aminopropylagmatine ureohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N1-aminopropylagmatine + H2O = spermidine + urea." [GOC:jl, IMG:03079, PMID:15983049]
subset: gosubset_prok
xref: EC:3.5.3.-
xref: IMG:03079
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0043921
name: modulation by host of viral transcription
namespace: biological_process
def: "Any process by which a host organism modulates the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GOC:jl]
synonym: "regulation by host of viral transcription" EXACT []
synonym: "regulation of viral transcription by host " EXACT []
is_a: GO:0046782 ! regulation of viral transcription
is_a: GO:0052472 ! modulation by host of symbiont transcription

[Term]
id: GO:0043922
name: negative regulation by host of viral transcription
namespace: biological_process
def: "Any process by which a host organism stops, prevents or reduces the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GOC:jl]
synonym: "negative regulation of viral transcription by host" EXACT []
is_a: GO:0032897 ! negative regulation of viral transcription
is_a: GO:0043921 ! modulation by host of viral transcription

[Term]
id: GO:0043923
name: positive regulation by host of viral transcription
namespace: biological_process
def: "Any process by which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GOC:jl]
synonym: "positive regulation of viral transcription by host" EXACT []
is_a: GO:0043921 ! modulation by host of viral transcription
is_a: GO:0050434 ! positive regulation of viral transcription

[Term]
id: GO:0043924
name: suramin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms." [ChEBI:45906, GOC:jl, Wikipedia:Suramin]
synonym: "Germanin binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0043927
name: exonucleolytic nuclear-transcribed mRNA catabolic process involved in endonucleolytic cleavage-dependent decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap." [GOC:mtg_mpo]
is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic
relationship: part_of GO:0000294 ! nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay

[Term]
id: GO:0043928
name: exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail." [GOC:mtg_mpo]
is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic
relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

[Term]
id: GO:0043929
name: primary ovarian follicle growth during double layer follicle stage
namespace: biological_process
def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle), during the double layer follicle stage of oogenesis." [GOC:mtg_mpo]
is_a: GO:0001545 ! primary ovarian follicle growth
relationship: part_of GO:0048161 ! double layer follicle stage, oogenesis

[Term]
id: GO:0043930
name: primary ovarian follicle growth during primary follicle stage
namespace: biological_process
def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle) during the primary follicle stage of oogenesis." [GOC:mtg_mpo]
is_a: GO:0001545 ! primary ovarian follicle growth
relationship: part_of GO:0048160 ! primary follicle stage, oogenesis

[Term]
id: GO:0043931
name: ossification involved in bone maturation
namespace: biological_process
def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state." [GOC:dph, GOC:mah, GOC:mtg_mpo]
synonym: "ossification involved in skeletal development" EXACT [GOC:dph]
is_a: GO:0001503 ! ossification
relationship: part_of GO:0070977 ! bone maturation

[Term]
id: GO:0043932
name: ossification involved in bone remodeling
namespace: biological_process
def: "The formation of bone involved in the continuous turnover of bone matrix and mineral." [GOC:mtg_mpo]
synonym: "ossification involved in bone remodelling" RELATED []
is_a: GO:0001503 ! ossification
relationship: part_of GO:0046849 ! bone remodeling

[Term]
id: GO:0043933
name: macromolecular complex subunit organization
namespace: biological_process
alt_id: GO:0034600
def: "Any process by which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a macromolecular complex." [GOC:mtg_mpo]
subset: gosubset_prok
synonym: "macromolecular complex organization" EXACT []
synonym: "macromolecular complex subunit organisation" EXACT [GOC:curators]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0043934
name: sporulation
namespace: biological_process
def: "The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo]
xref: Wikipedia:Spore
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0043935
name: sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_08]
is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore
is_a: GO:0034293 ! sexual sporulation

[Term]
id: GO:0043936
name: asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_08]
is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore
is_a: GO:0030436 ! asexual sporulation

[Term]
id: GO:0043937
name: regulation of sporulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0043934 ! sporulation

[Term]
id: GO:0043938
name: positive regulation of sporulation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators]
is_a: GO:0043937 ! regulation of sporulation
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0043934 ! sporulation

[Term]
id: GO:0043939
name: negative regulation of sporulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators]
is_a: GO:0043937 ! regulation of sporulation
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0043934 ! sporulation

[Term]
id: GO:0043940
name: regulation of sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_08]
is_a: GO:0034306 ! regulation of sexual sporulation
is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore
relationship: regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043941
name: positive regulation of sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_08]
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0045881 ! positive regulation of sporulation resulting in formation of a cellular spore
relationship: positively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043942
name: negative regulation of sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_08]
is_a: GO:0042174 ! negative regulation of sporulation resulting in formation of a cellular spore
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
relationship: negatively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043943
name: regulation of asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_08]
is_a: GO:0034305 ! regulation of asexual sporulation
is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore
relationship: regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043944
name: negative regulation of asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_08]
is_a: GO:0042174 ! negative regulation of sporulation resulting in formation of a cellular spore
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
relationship: negatively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043945
name: positive regulation of asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_08]
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0045881 ! positive regulation of sporulation resulting in formation of a cellular spore
relationship: positively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0043946
name: positive regulation of catalytic activity in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "activation of enzyme activity in other organism" NARROW []
synonym: "activation of enzyme activity in other organism during symbiotic interaction" NARROW []
synonym: "up regulation of enzyme activity in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation of enzyme activity in other organism during symbiotic interaction" EXACT []
synonym: "upregulation of enzyme activity in other organism during symbiotic interaction" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0052203 ! modulation of catalytic activity in other organism during symbiotic interaction

[Term]
id: GO:0043947
name: positive regulation by host of symbiont catalytic activity
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:pamgo_08]
synonym: "activation by host of symbiont enzyme activity" NARROW []
synonym: "activation of symbiont enzyme activity" NARROW []
synonym: "positive regulation by host of symbiont enzyme activity" EXACT []
synonym: "up regulation by host of symbiont enzyme activity" EXACT []
synonym: "up-regulation by host of symbiont enzyme activity" EXACT []
synonym: "upregulation by host of symbiont enzyme activity" EXACT []
is_a: GO:0043946 ! positive regulation of catalytic activity in other organism during symbiotic interaction
is_a: GO:0052405 ! negative regulation by host of symbiont molecular function
is_a: GO:0052422 ! modulation by host of symbiont catalytic activity

[Term]
id: GO:0043948
name: positive regulation by symbiont of host catalytic activity
namespace: biological_process
def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host enzyme activity" NARROW []
synonym: "activation of host enzyme activity" NARROW []
synonym: "positive regulation by symbiont of host enzyme activity" EXACT []
synonym: "up regulation by symbiont of host enzyme activity" EXACT []
synonym: "up-regulation by symbiont of host enzyme activity" EXACT []
synonym: "upregulation by symbiont of host enzyme activity" EXACT []
is_a: GO:0043946 ! positive regulation of catalytic activity in other organism during symbiotic interaction
is_a: GO:0052056 ! negative regulation by symbiont of host molecular function
is_a: GO:0052148 ! modulation by symbiont of host catalytic activity

[Term]
id: GO:0043949
name: regulation of cAMP-mediated signaling
namespace: biological_process
def: "Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl]
synonym: "regulation of cAMP-mediated signalling" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0019933 ! cAMP-mediated signaling

[Term]
id: GO:0043950
name: positive regulation of cAMP-mediated signaling
namespace: biological_process
def: "Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl]
synonym: "positive regulation of cAMP-mediated signalling" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0043949 ! regulation of cAMP-mediated signaling
relationship: positively_regulates GO:0019933 ! cAMP-mediated signaling

[Term]
id: GO:0043951
name: negative regulation of cAMP-mediated signaling
namespace: biological_process
def: "Any process which stops, prevents or reduces the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl]
synonym: "negative regulation of cAMP-mediated signalling" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0043949 ! regulation of cAMP-mediated signaling
relationship: negatively_regulates GO:0019933 ! cAMP-mediated signaling

[Term]
id: GO:0043952
name: protein transport by the Sec complex
namespace: biological_process
def: "The process by which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular structure term 'cell envelope Sec protein transport complex ; GO:0031522'. For proteins involved in bacterial Type II secretion across the outer membrane, consider annotating to 'protein secretion by the Type II secretion system ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'SRP-dependent cotranslational protein targeting to membrane, translocation ; GO:0006616'. Note that this term is used for annotation of proteins that compose the transport complex but not the proteins being transported.
synonym: "protein secretion by the Sec complex" NARROW []
synonym: "protein translocation by the Sec complex" NARROW []
is_a: GO:0015031 ! protein transport

[Term]
id: GO:0043953
name: protein transport by the Tat complex
namespace: biological_process
def: "The process by which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex." [GOC:pamgo_curators]
comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular structure term 'TAT protein translocation system complex ; GO:0033281'. Note that this term is used for annotation of proteins that compose the transport complex but not the proteins being transported.
subset: gosubset_prok
synonym: "protein secretion by the TAT complex" NARROW []
synonym: "protein translocation by the TAT complex" NARROW []
synonym: "protein translocation by the Twin-arginine translocation complex" NARROW []
is_a: GO:0015031 ! protein transport

[Term]
id: GO:0043954
name: cellular component maintenance
namespace: biological_process
def: "The organization process by which a cellular component is preserved in a stable functional or structural state." [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0043955
name: 3-hydroxypropionyl-CoA synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + pyrophosphate." [GOC:jl, PMID:11821399]
comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399.
subset: gosubset_prok
synonym: "3-hydroxy propionyl-CoA synthetase activity" EXACT []
synonym: "acetyl-coenzyme A synthetase" BROAD []
synonym: "acetyl-coenzyme A synthetase/GroES-like domain" NARROW []
synonym: "AMP-dependent synthetase and ligase" BROAD []
synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BROAD []
synonym: "enoyl-CoA hydratase/isomerase" BROAD []
xref: EC:6.2.1.-
xref: IMG:03293
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0043956
name: 3-hydroxypropionyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypropionyl-CoA = acrylyl-CoA + H2O." [GOC:jl, PMID:11821399]
comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399.
subset: gosubset_prok
synonym: "3-hydroxy propionyl-CoA dehydratase activity" EXACT []
synonym: "acetyl-coenzyme A synthetase" BROAD []
synonym: "acetyl-coenzyme A synthetase/GroES-like domain" BROAD []
synonym: "AMP-dependent synthetase and ligase" BROAD []
synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BROAD []
synonym: "enoyl-CoA hydratase/isomerase" BROAD []
xref: EC:4.2.1.-
xref: IMG:03294
xref: MetaCyc:RXN-6383
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043957
name: acrylyl-CoA reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: acrylyl-CoA + NADPH + H+ = propionyl-CoA + NADP+." [GOC:jl, PMID:11821399]
comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399.
subset: gosubset_prok
synonym: "acetyl-coenzyme A synthetase" BROAD []
synonym: "acetyl-coenzyme A synthetase/GroES-like domain" BROAD []
synonym: "AMP-dependent synthetase and ligase" BROAD []
synonym: "AMP-dependent synthetase and ligase:enoyl-CoA hydratase/isomerase" BROAD []
synonym: "enoyl-CoA hydratase/isomerase" BROAD []
xref: EC:1.3.1.-
xref: IMG:03302
xref: MetaCyc:RXN-9087
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043958
name: acryloyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced electron transferring flavoprotein + NADH + acrylyl-CoA = NAD+ + oxidized electron transferring flavoprotein + propionyl-CoA." [GOC:jl, PMID:12603323]
comment: Note that this function is part of the process of L-alanine fermentation to propionate.
subset: gosubset_prok
synonym: "acryloyl-coenzyme A reductase activity" EXACT []
synonym: "acrylyl-CoA reductase (NADH)" EXACT []
synonym: "propionyl-CoA dehydrogenase" EXACT []
xref: EC:1.3.1.-
xref: IMG:01636
xref: MetaCyc:CPLX-7247
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0043959
name: L-erythro-3-methylmalyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: propionyl-CoA + glyoxylate = L-erythro-3-methylmalyl-CoA." [GOC:jl, IMG:03303]
subset: gosubset_prok
synonym: "HpcH/HpaI aldolase" RELATED []
xref: EC:4.1.3.-
xref: IMG:03303
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0043960
name: L-erythro-3-methylmalyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O." [GOC:jl, IMG:03304]
subset: gosubset_prok
xref: EC:4.2.1.-
xref: IMG:03304
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0043961
name: succinyl-CoA:(R)-citramalate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA." [GOC:jl, IMG:03306, PMID:17259315]
subset: gosubset_prok
synonym: "L-carnitine dehydratase/bile acid-inducible protein F" RELATED []
synonym: "succinyl-CoA:(R)-citramalate CoA transferase activity" EXACT []
synonym: "succinyl-CoA:R-citramalate CoA transferase" EXACT []
xref: EC:2.8.3.-
xref: IMG:03306
xref: MetaCyc:RXN-8966
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0043962
name: negative regulation by host of symbiont adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host adenylate cyclase-mediated signal transduction; GO:0075336".
is_a: GO:0052492 ! negative regulation by host of symbiont signal transduction pathway
is_a: GO:0075332 ! modulation by host of symbiont adenylate cyclase-mediated signal transduction

[Term]
id: GO:0043963
name: modulation by symbiont of host adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "Any process by which the symbiont modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway

[Term]
id: GO:0043964
name: positive regulation by symbiont of host adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0043963 ! modulation by symbiont of host adenylate cyclase-mediated signal transduction
is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway

[Term]
id: GO:0043965
name: negative regulation by symbiont of host adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
subset: gosubset_prok
is_a: GO:0043963 ! modulation by symbiont of host adenylate cyclase-mediated signal transduction
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway

[Term]
id: GO:0043966
name: histone H3 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group." [GOC:jl]
is_a: GO:0016573 ! histone acetylation

[Term]
id: GO:0043967
name: histone H4 acetylation
namespace: biological_process
def: "The modification of histone H4 by the addition of an acetyl group." [GOC:jl]
is_a: GO:0016573 ! histone acetylation

[Term]
id: GO:0043968
name: histone H2A acetylation
namespace: biological_process
def: "The modification of histone H2A by the addition of an acetyl group." [GOC:jl]
is_a: GO:0016573 ! histone acetylation

[Term]
id: GO:0043969
name: histone H2B acetylation
namespace: biological_process
def: "The modification of histone H2B by the addition of an acetyl group." [GOC:jl]
is_a: GO:0016573 ! histone acetylation

[Term]
id: GO:0043970
name: histone H3-K9 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl]
synonym: "histone H3 acetylation at K9" EXACT []
synonym: "histone H3K9 acetylation" EXACT []
is_a: GO:0043966 ! histone H3 acetylation

[Term]
id: GO:0043971
name: histone H3-K18 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 18 of the histone." [GOC:jl]
synonym: "histone H3 acetylation at K18" EXACT []
synonym: "histone H3K18 acetylation" EXACT []
is_a: GO:0043966 ! histone H3 acetylation

[Term]
id: GO:0043972
name: histone H3-K23 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 23 of the histone." [GOC:jl]
synonym: "histone H3 acetylation at K23" EXACT []
synonym: "histone H3K23 acetylation" EXACT []
is_a: GO:0043966 ! histone H3 acetylation

[Term]
id: GO:0043973
name: histone H3-K4 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 4 of the histone." [GOC:jl]
synonym: "histone H3 acetylation at K4" EXACT []
synonym: "histone H3K4 acetylation" EXACT []
is_a: GO:0043966 ! histone H3 acetylation

[Term]
id: GO:0043974
name: histone H3-K27 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 27 of the histone." [GOC:jl]
synonym: "histone H3 acetylation at K27" EXACT []
synonym: "histone H3K27 acetylation" EXACT []
is_a: GO:0043966 ! histone H3 acetylation

[Term]
id: GO:0043975
name: histone H3-K36 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 36 of the histone." [GOC:jl]
synonym: "histone H3 acetylation at K36" EXACT []
synonym: "histone H3K36 acetylation" EXACT []
is_a: GO:0043966 ! histone H3 acetylation

[Term]
id: GO:0043976
name: histone H3-K79 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 79 of the histone." [GOC:jl]
synonym: "histone H3 acetylation at K79" EXACT []
synonym: "histone H3K79 acetylation" EXACT []
is_a: GO:0043966 ! histone H3 acetylation

[Term]
id: GO:0043977
name: histone H2A-K5 acetylation
namespace: biological_process
def: "The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl]
synonym: "histone H2A acetylation at K5" EXACT []
is_a: GO:0043968 ! histone H2A acetylation

[Term]
id: GO:0043978
name: histone H2A-K9 acetylation
namespace: biological_process
def: "The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl]
synonym: "histone H2A acetylation at K9" EXACT []
is_a: GO:0043968 ! histone H2A acetylation

[Term]
id: GO:0043979
name: histone H2B-K5 acetylation
namespace: biological_process
def: "The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl]
synonym: "histone H2B acetylation at K5" EXACT []
is_a: GO:0043969 ! histone H2B acetylation

[Term]
id: GO:0043980
name: histone H2B-K12 acetylation
namespace: biological_process
def: "The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 12 of the histone." [GOC:jl]
synonym: "histone H2B acetylation at K12" EXACT []
is_a: GO:0043969 ! histone H2B acetylation

[Term]
id: GO:0043981
name: histone H4-K5 acetylation
namespace: biological_process
def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl]
synonym: "histone H4 acetylation at K5" EXACT []
is_a: GO:0043967 ! histone H4 acetylation

[Term]
id: GO:0043982
name: histone H4-K8 acetylation
namespace: biological_process
def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone." [GOC:jl]
synonym: "histone H4 acetylation at K8" EXACT []
is_a: GO:0043967 ! histone H4 acetylation

[Term]
id: GO:0043983
name: histone H4-K12 acetylation
namespace: biological_process
def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone." [GOC:jl]
synonym: "histone H4 acetylation at K12" EXACT []
is_a: GO:0043967 ! histone H4 acetylation

[Term]
id: GO:0043984
name: histone H4-K16 acetylation
namespace: biological_process
def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone." [GOC:jl]
synonym: "histone H4 acetylation at K16" EXACT []
is_a: GO:0043967 ! histone H4 acetylation

[Term]
id: GO:0043985
name: histone H4-R3 methylation
namespace: biological_process
def: "The modification of histone H4 by addition of a methyl group to arginine at position 3 of the histone." [GOC:mah]
synonym: "histone H4 methylation at R3" EXACT []
synonym: "histone H4 R3 methylation" EXACT []
synonym: "histone H4R3me" EXACT []
is_a: GO:0034969 ! histone arginine methylation

[Term]
id: GO:0043987
name: histone H3-S10 phosphorylation
namespace: biological_process
alt_id: GO:0043986
def: "The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone." [GOC:jl]
synonym: "histone H3 phosphorylation at S10" EXACT []
synonym: "histone H3S10 phosphorylation" EXACT []
is_a: GO:0016572 ! histone phosphorylation

[Term]
id: GO:0043988
name: histone H3-S28 phosphorylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone." [GOC:jl]
synonym: "histone H3 phosphorylation at S28" EXACT []
synonym: "histone H3S28 phosphorylation" EXACT []
is_a: GO:0016572 ! histone phosphorylation

[Term]
id: GO:0043989
name: histone H4-S1 phosphorylation
namespace: biological_process
def: "The modification of histone H4 by the addition of an phosphate group to a serine residue at position 1 of the histone." [GOC:jl]
synonym: "histone H4 phosphorylation at S1" EXACT []
synonym: "histone H4S1 phosphorylation" EXACT []
is_a: GO:0016572 ! histone phosphorylation

[Term]
id: GO:0043990
name: histone H2A-S1 phosphorylation
namespace: biological_process
def: "The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone." [GOC:jl]
synonym: "histone H2A phosphorylation at S1" EXACT []
synonym: "histone H2AS1 phosphorylation" EXACT []
is_a: GO:0016572 ! histone phosphorylation

[Term]
id: GO:0043991
name: histone H2B-S14 phosphorylation
namespace: biological_process
def: "The modification of histone H2B by the addition of an phosphate group to a serine residue at position 14 of the histone." [GOC:jl]
synonym: "histone H2B phosphorylation at S14" EXACT []
synonym: "histone H2BS14 phosphorylation" EXACT []
is_a: GO:0016572 ! histone phosphorylation

[Term]
id: GO:0043992
name: histone acetyltransferase activity (H3-K9 specific)
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group onto lysine at position 9 of the histone H3 protein." [GOC:jl]
synonym: "histone lysine N-acetyltransferase activity (H3-K9 specific)" EXACT []
is_a: GO:0010484 ! H3 histone acetyltransferase activity

[Term]
id: GO:0043993
name: histone acetyltransferase activity (H3-K18 specific)
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group to lysine at position 18 of the histone H3." [GOC:jl]
synonym: "histone lysine N-acetyltransferase activity (H3-K18 specific)" EXACT []
is_a: GO:0010484 ! H3 histone acetyltransferase activity

[Term]
id: GO:0043994
name: histone acetyltransferase activity (H3-K23 specific)
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group onto lysine at position 23 of the histone H3 protein." [GOC:jl]
synonym: "histone lysine N-acetyltransferase activity (H3-K23 specific)" EXACT []
is_a: GO:0010484 ! H3 histone acetyltransferase activity

[Term]
id: GO:0043995
name: histone acetyltransferase activity (H4-K5 specific)
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group onto lysine at position 5 of the histone H4 protein." [GOC:jl]
synonym: "histone lysine N-acetyltransferase activity (H4-K5 specific)" EXACT []
is_a: GO:0010485 ! H4 histone acetyltransferase activity

[Term]
id: GO:0043996
name: histone acetyltransferase activity (H4-K8 specific)
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group onto lysine at position 8 of the histone H4 protein." [GOC:jl]
synonym: "histone lysine N-acetyltransferase activity (H4-K8 specific)" EXACT []
is_a: GO:0010485 ! H4 histone acetyltransferase activity

[Term]
id: GO:0043997
name: histone acetyltransferase activity (H4-K12 specific)
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group onto lysine at position 12 of the histone H4 protein." [GOC:jl]
synonym: "histone lysine N-acetyltransferase activity (H4-K12 specific)" EXACT []
is_a: GO:0010485 ! H4 histone acetyltransferase activity

[Term]
id: GO:0043998
name: H2A histone acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group to a lysine of the histone H2A." [GOC:jl]
synonym: "H2A histone lysine N-acetyltransferase activity" EXACT []
is_a: GO:0004402 ! histone acetyltransferase activity

[Term]
id: GO:0043999
name: histone acetyltransferase activity (H2A-K5 specific)
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group to lysine at position 5 of the histone H2A." [GOC:jl]
synonym: "histone lysine N-acetyltransferase activity (H2A-K5 specific)" EXACT []
is_a: GO:0043998 ! H2A histone acetyltransferase activity

[Term]
id: GO:0044000
name: movement in host
namespace: biological_process
def: "The process by which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "movement of symbiont in host" EXACT []
synonym: "movement of symbiont within host" EXACT []
synonym: "movement within host" EXACT []
synonym: "symbiont movement in host" EXACT []
synonym: "symbiont movement within host" RELATED []
is_a: GO:0051814 ! movement in other organism during symbiotic interaction
is_a: GO:0052126 ! movement in host environment

[Term]
id: GO:0044001
name: migration in host
namespace: biological_process
def: "The directional movement of an organism from one place to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "migration within host" EXACT []
is_a: GO:0044000 ! movement in host
is_a: GO:0051815 ! migration in other organism during symbiotic interaction

[Term]
id: GO:0044002
name: acquisition of nutrients from host
namespace: biological_process
def: "The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051701 ! interaction with host
is_a: GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction

[Term]
id: GO:0044003
name: modification by symbiont of host morphology or physiology
namespace: biological_process
def: "The process by which an organism effects a change in the structure or processes of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051701 ! interaction with host
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction

[Term]
id: GO:0044004
name: disruption by symbiont of host cells
namespace: biological_process
def: "Any process by which an organism has a negative effect on the functioning of the host's cells. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "disruption by organism of host cells" EXACT []
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0051818 ! disruption of cells of other organism during symbiotic interaction

[Term]
id: GO:0044005
name: induction by symbiont in host of tumor, nodule, or growth
namespace: biological_process
def: "The process by which an organism causes the formation of an abnormal mass of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0051819 ! induction of tumor, nodule, or growth in other organism during symbiotic interaction

[Term]
id: GO:0044006
name: induction by symbiont in host of tumor, nodule, or growth containing transformed cells
namespace: biological_process
def: "The process by which an organism causes the formation in its host organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
is_a: GO:0044005 ! induction by symbiont in host of tumor, nodule, or growth
is_a: GO:0051820 ! induction of tumor, nodule, or growth containing transformed cells in other organism during symbiotic interaction

[Term]
id: GO:0044007
name: dissemination or transmission of symbiont from host
namespace: biological_process
def: "The movement of an organism from a host to another host or from a host to another place in the environment. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "dissemination or transmission of organism from host" EXACT []
is_a: GO:0051701 ! interaction with host
is_a: GO:0051821 ! dissemination or transmission of organism from other organism during symbiotic interaction

[Term]
id: GO:0044008
name: dissemination or transmission of symbiont from host by vector
namespace: biological_process
def: "The movement of an organism from one host to another (or another place in the environment) by means of a third organism (often an insect or other animal). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "dissemination or transmission of organism from host by vector" EXACT []
is_a: GO:0044007 ! dissemination or transmission of symbiont from host
is_a: GO:0051822 ! dissemination or transmission of organism from other organism by vector during symbiotic interaction

[Term]
id: GO:0044009
name: viral transmission by vector
namespace: biological_process
def: "The transfer of virions by means of an organism (often an insect or other animal) in order to create new infection." [GOC:cc]
is_a: GO:0019089 ! transmission of virus
is_a: GO:0044008 ! dissemination or transmission of symbiont from host by vector

[Term]
id: GO:0044010
name: single-species biofilm formation
namespace: biological_process
def: "A process whereby microorganisms of the same species attach to and grow on a surface such, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc]
subset: gosubset_prok
is_a: GO:0042710 ! biofilm formation

[Term]
id: GO:0044011
name: single-species biofilm formation on inanimate substrate
namespace: biological_process
def: "A process whereby microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044010 ! single-species biofilm formation
is_a: GO:0051703 ! intraspecies interaction between organisms

[Term]
id: GO:0044012
name: histone acetyltransferase activity (H2A-K9 specific)
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group to lysine at position 9 of the histone H2A." [GOC:jl]
synonym: "histone lysine N-acetyltransferase activity (H2A-K9 specific)" EXACT []
is_a: GO:0043998 ! H2A histone acetyltransferase activity

[Term]
id: GO:0044013
name: H2B histone acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group to a lysine of the histone H2B." [GOC:jl]
synonym: "H2B histone lysine N-acetyltransferase activity" EXACT []
is_a: GO:0004402 ! histone acetyltransferase activity

[Term]
id: GO:0044014
name: histone acetyltransferase activity (H2B-K5 specific)
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group to lysine at position 5 of the histone H2B." [GOC:jl]
synonym: "histone lysine N-acetyltransferase activity (H2B-K5 specific)" EXACT []
is_a: GO:0044013 ! H2B histone acetyltransferase activity

[Term]
id: GO:0044015
name: histone acetyltransferase activity (H2B-K12 specific)
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group to lysine at position 12 of the histone H2B." [GOC:jl]
synonym: "histone lysine N-acetyltransferase activity (H2B-K12 specific)" EXACT []
is_a: GO:0044013 ! H2B histone acetyltransferase activity

[Term]
id: GO:0044016
name: histone acetyltransferase activity (H3-K4 specific)
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group to lysine at position 4 of the histone H3." [GOC:jl]
synonym: "histone lysine N-acetyltransferase activity (H3-K4 specific)" EXACT []
is_a: GO:0010484 ! H3 histone acetyltransferase activity

[Term]
id: GO:0044017
name: histone acetyltransferase activity (H3-K27 specific)
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group to lysine at position 27 of the histone H3." [GOC:jl]
synonym: "histone lysine N-acetyltransferase activity (H3-K27 specific)" EXACT []
is_a: GO:0010484 ! H3 histone acetyltransferase activity

[Term]
id: GO:0044018
name: histone acetyltransferase activity (H3-K36 specific)
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group to lysine at position 36 of the histone H3." [GOC:jl]
synonym: "histone lysine N-acetyltransferase activity (H3-K36 specific)" EXACT []
is_a: GO:0010484 ! H3 histone acetyltransferase activity

[Term]
id: GO:0044019
name: histone acetyltransferase activity (H3-K72 specific)
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group onto lysine at position 72 of the histone H3 protein." [GOC:mah]
synonym: "histone lysine N-acetyltransferase activity (H3-K72 specific)" EXACT []
is_a: GO:0010484 ! H3 histone acetyltransferase activity

[Term]
id: GO:0044020
name: histone methyltransferase activity (H4-R3 specific)
namespace: molecular_function
def: "Catalysis of the addition of a methyl group to arginine at position 3 of the histone H4." [GOC:jl]
synonym: "histone methylase activity (H4-R3 specific)" EXACT [GOC:mah]
synonym: "histone-arginine N-methyltransferase activity (H4-R3 specific)" EXACT []
is_a: GO:0008469 ! histone-arginine N-methyltransferase activity

[Term]
id: GO:0044021
name: histone kinase activity (H3-S3 specific)
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to the serine-3 residue of the N-terminal tail of histone H3." [GOC:jl]
synonym: "histone serine kinase activity (H3-S3 specific)" EXACT []
synonym: "histone-serine kinase activity (H3-S3 specific)" EXACT []
is_a: GO:0035174 ! histone serine kinase activity

[Term]
id: GO:0044022
name: histone kinase activity (H3-S28 specific)
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to the serine-28 residue of the N-terminal tail of histone H3." [GOC:jl]
synonym: "histone serine kinase activity (H3-S28 specific)" EXACT []
synonym: "histone-serine kinase activity (H3-S28 specific)" EXACT []
is_a: GO:0035174 ! histone serine kinase activity

[Term]
id: GO:0044023
name: histone kinase activity (H4-S1 specific)
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H4." [GOC:jl]
synonym: "histone serine kinase activity (H4-S1 specific)" EXACT []
synonym: "histone-serine kinase activity (H4-S1 specific)" EXACT []
is_a: GO:0035174 ! histone serine kinase activity

[Term]
id: GO:0044024
name: histone kinase activity (H2A-S1 specific)
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H2A." [GOC:jl]
synonym: "histone serine kinase activity (H2A-S1 specific)" EXACT []
synonym: "histone-serine kinase activity (H2A-S1 specific)" EXACT []
is_a: GO:0035174 ! histone serine kinase activity

[Term]
id: GO:0044025
name: histone kinase activity (H2B-S14 specific)
namespace: molecular_function
def: "Catalysis of the transfer of a phosphate group to the serine-14 residue of the N-terminal tail of histone H2B." [GOC:jl]
synonym: "histone serine kinase activity (H2B-S14 specific)" EXACT []
synonym: "histone-serine kinase activity (H2B-S14 specific)" EXACT []
is_a: GO:0035174 ! histone serine kinase activity

[Term]
id: GO:0044026
name: DNA hypermethylation
namespace: biological_process
def: "An increase in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/]
is_a: GO:0044030 ! regulation of DNA methylation

[Term]
id: GO:0044027
name: hypermethylation of CpG island
namespace: biological_process
def: "An increase in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes." [GOC:jl, Wikipedia:Cpg_island]
synonym: "DNA hypermethylation of CpG island" EXACT []
is_a: GO:0044026 ! DNA hypermethylation

[Term]
id: GO:0044028
name: DNA hypomethylation
namespace: biological_process
def: "An decrease in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/hypomethylation]
is_a: GO:0044030 ! regulation of DNA methylation

[Term]
id: GO:0044029
name: hypomethylation of CpG island
namespace: biological_process
def: "An decrease in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes." [GOC:jl, Wikipedia:Cpg_island]
synonym: "DNA hypomethylation of CpG island" EXACT []
is_a: GO:0044028 ! DNA hypomethylation

[Term]
id: GO:0044030
name: regulation of DNA methylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:jl]
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0006306 ! DNA methylation

[Term]
id: GO:0044031
name: modification by symbiont of host protein by phosphorylation
namespace: biological_process
def: "The process by which an organism adds a phosphate group to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that phosphorylate host proteins, consider annotation to 'protein amino acid phosphorylation ; GO:0006468'. Consider also annotation to the molecular function term 'protein kinase activity ; GO:0004672'.
subset: gosubset_prok
is_a: GO:0075345 ! modification by symbiont of host protein

[Term]
id: GO:0044032
name: modulation by symbiont of indole acetic acid levels in host
namespace: biological_process
def: "The alteration by an organism of the levels of indole acetic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that regulate indole acetic acid levels in the host, consider annotating to 'auxin homeostasis ; GO:0010252'.
synonym: "modulation by symbiont of auxin levels in host" BROAD []
synonym: "modulation by symbiont of IAA levels in host" EXACT []
is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels

[Term]
id: GO:0044033
name: multi-organism metabolic process
namespace: biological_process
def: "Any metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves more than one organism." [GOC:jl]
subset: gosubset_prok
synonym: "multi-organism metabolism" EXACT []
synonym: "multi-organismal metabolic process" EXACT []
synonym: "multi-organismal metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0044034
name: multi-organism biosynthetic process
namespace: biological_process
def: "Any biosynthetic process - chemical reactions and pathways resulting in the formation of substances - which involves more than one organism." [GOC:jl]
subset: gosubset_prok
synonym: "multi-organism biosynthesis" EXACT []
synonym: "multi-organismal biosynthesis" EXACT []
synonym: "multi-organismal biosynthetic process" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0044033 ! multi-organism metabolic process

[Term]
id: GO:0044035
name: multi-organism catabolic process
namespace: biological_process
def: "Any catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves more than one organism." [GOC:jl]
subset: gosubset_prok
synonym: "multi-organism catabolism" EXACT []
synonym: "multi-organismal catabolic process" EXACT []
synonym: "multi-organismal catabolism" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0044033 ! multi-organism metabolic process

[Term]
id: GO:0044036
name: cell wall macromolecule metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mah]
is_a: GO:0043170 ! macromolecule metabolic process
relationship: part_of GO:0071554 ! cell wall organization or biogenesis

[Term]
id: GO:0044037
name: multi-organism cell wall macromolecule metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving macromolecules forming, or destined to form, part of a cell wall, involving more than one organism. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah, GOC:tair_curators]
subset: gosubset_prok
synonym: "multi-organism cell wall macromolecule metabolism" EXACT [GOC:mah]
is_a: GO:0044033 ! multi-organism metabolic process
is_a: GO:0044036 ! cell wall macromolecule metabolic process

[Term]
id: GO:0044038
name: cell wall macromolecule biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a cell wall." [GOC:go_curators]
subset: gosubset_prok
synonym: "cell wall macromolecule anabolism" EXACT [GOC:mah]
synonym: "cell wall macromolecule biosynthesis" EXACT [GOC:mah]
synonym: "cell wall macromolecule biosynthetic process at cellular level" EXACT [GOC:mah]
synonym: "cell wall macromolecule synthesis" EXACT [GOC:mah]
synonym: "cellular cell wall macromolecule biosynthetic process" EXACT [GOC:mah]
is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process
is_a: GO:0070589 ! cellular component macromolecule biosynthetic process
relationship: part_of GO:0042546 ! cell wall biogenesis

[Term]
id: GO:0044039
name: cellular cell wall macromolecule catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of macromolecules forming part of a cell wall, occurring at the level of the cell." [GOC:go_curators]
subset: gosubset_prok
synonym: "cellular cell wall macromolecule breakdown" EXACT [GOC:mah]
synonym: "cellular cell wall macromolecule catabolism" EXACT [GOC:mah]
synonym: "cellular cell wall macromolecule degradation" EXACT [GOC:mah]
is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process
is_a: GO:0016998 ! cell wall macromolecule catabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0044040
name: multi-organism carbohydrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, that involve more than one organism." [GOC:jl]
subset: gosubset_prok
synonym: "main pathways of carbohydrate metabolic process" NARROW []
synonym: "main pathways of carbohydrate metabolism" NARROW []
synonym: "multi-organism carbohydrate metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0044033 ! multi-organism metabolic process

[Term]
id: GO:0044041
name: multi-organism carbohydrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, involving more than one organism." [GOC:jl]
subset: gosubset_prok
synonym: "multi-organism carbohydrate breakdown" EXACT []
synonym: "multi-organism carbohydrate catabolism" EXACT []
synonym: "multi-organism carbohydrate degradation" EXACT []
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0044040 ! multi-organism carbohydrate metabolic process

[Term]
id: GO:0044042
name: glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl]
subset: gosubset_prok
synonym: "glucan metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0044043
name: multi-organism glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, involving more than one organism." [ISBN:0198547684]
subset: gosubset_prok
synonym: "multi-organism glucan metabolism" EXACT []
is_a: GO:0044040 ! multi-organism carbohydrate metabolic process
is_a: GO:0044042 ! glucan metabolic process

[Term]
id: GO:0044044
name: interaction with host via substance in symbiont surface
namespace: biological_process
def: "An interaction with the host organism mediated by a substance on the surface of the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
subset: gosubset_prok
is_a: GO:0051701 ! interaction with host

[Term]
id: GO:0044045
name: interaction with host via substance in symbiont cell outer membrane
namespace: biological_process
def: "An interaction with the host organism mediated by a substance in the symbiont cell outer membrane - a lipid bilayer that forms the outermost layer of the symbiont cell envelope. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
subset: gosubset_prok
is_a: GO:0044044 ! interaction with host via substance in symbiont surface

[Term]
id: GO:0044046
name: interaction with host via substance released outside of symbiont
namespace: biological_process
def: "An interaction with the host organism mediated by a substance that is released by the other organism. This includes substances that are released via pathogen cell lysis." [MITRE:tk]
subset: gosubset_prok
synonym: "interaction with host via substance released outside of symbiont cells" EXACT []
is_a: GO:0051701 ! interaction with host

[Term]
id: GO:0044047
name: interaction with host via protein secreted by type I secretion system
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type I secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
subset: gosubset_prok
is_a: GO:0052048 ! interaction with host via secreted substance during symbiotic interaction

[Term]
id: GO:0044048
name: interaction with host via protein secreted by type V secretion system
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type V secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
is_a: GO:0052048 ! interaction with host via secreted substance during symbiotic interaction

[Term]
id: GO:0044049
name: interaction with host via protein secreted by type VI secretion system
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type VI secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
is_a: GO:0052048 ! interaction with host via secreted substance during symbiotic interaction

[Term]
id: GO:0044050
name: interaction with host via substance released by sporangium lysis
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released via rupture of symbiont sporangia, structures producing and containing spores. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
subset: gosubset_prok
synonym: "interaction with host via substance released by lysis of symbiont sporangium" RELATED []
synonym: "interaction with host via substance released by sporangia lysis" EXACT []
is_a: GO:0044046 ! interaction with host via substance released outside of symbiont

[Term]
id: GO:0044051
name: interaction with host via substance released by symbiont cytolysis
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released via cytolysis of symbiont cells. Cytolysis is the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]
subset: gosubset_prok
synonym: "interaction with host via substance released by cytolysis of symbiont" EXACT []
is_a: GO:0044046 ! interaction with host via substance released outside of symbiont

[Term]
id: GO:0044052
name: interaction with host via substance released by membrane budding
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released via symbiont membrane budding, the evagination of a membrane resulting in formation of a vesicle." [MITRE:tk]
subset: gosubset_prok
synonym: "interaction with host via substance released by symbiont membrane budding" EXACT []
is_a: GO:0044046 ! interaction with host via substance released outside of symbiont

[Term]
id: GO:0044053
name: translocation of peptides or proteins into host cell cytoplasm
namespace: biological_process
def: "The directed movement of peptides or proteins produced by a symbiont organism to a location within the host cell cytoplasm." [MITRE:tk]
subset: gosubset_prok
synonym: "translocation of symbiont peptides or proteins into host cell cytoplasm" EXACT []
synonym: "transport of peptides or proteins into host cell cytoplasm" EXACT []
is_a: GO:0042000 ! translocation of peptides or proteins into host

[Term]
id: GO:0044054
name: rounding by symbiont of host cells
namespace: biological_process
def: "Any process by which an organism causes host cells to change shape and become round." [MITRE:tk]
subset: gosubset_prok
is_a: GO:0044004 ! disruption by symbiont of host cells

[Term]
id: GO:0044055
name: modulation by symbiont of host system process
namespace: biological_process
def: "The alteration by a symbiont organism of the functioning of a system process in the host. A system process is a multicellular organismal process carried out by any of the organs or tissues in an organ system." [MITRE:tk]
subset: gosubset_prok
synonym: "regulation by symbiont of host system process " EXACT []
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0044057 ! regulation of system process

[Term]
id: GO:0044056
name: modulation by symbiont of host digestive system process
namespace: biological_process
def: "The alteration by a symbiont organism of the functioning of a digestive system process, a physical, chemical, or biochemical process carried out by the host organism to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [MITRE:tk]
synonym: "regulation by symbiont of host digestive system process" EXACT []
is_a: GO:0044055 ! modulation by symbiont of host system process
is_a: GO:0044058 ! regulation of digestive system process

[Term]
id: GO:0044057
name: regulation of system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." [GOC:jl]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0003008 ! system process

[Term]
id: GO:0044058
name: regulation of digestive system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jl]
is_a: GO:0044057 ! regulation of system process
relationship: regulates GO:0022600 ! digestive system process

[Term]
id: GO:0044059
name: modulation by symbiont of host endocrine process
namespace: biological_process
def: "The alteration by a symbiont organism of the functioning of a endocrine process, any of the hormonal, neural, and secretory processes that release products into the blood or lymph, in the host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "regulation by symbiont of host endocrine process" EXACT []
is_a: GO:0044055 ! modulation by symbiont of host system process
is_a: GO:0044060 ! regulation of endocrine process

[Term]
id: GO:0044060
name: regulation of endocrine process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [GOC:jl]
synonym: "regulation of endocrine system process" EXACT []
is_a: GO:0044057 ! regulation of system process
relationship: regulates GO:0050886 ! endocrine process

[Term]
id: GO:0044061
name: modulation by symbiont of host excretion
namespace: biological_process
def: "The alteration by a symbiont organism of the functioning of excretion, the elimination by the host organism of the waste products that arise as a result of metabolic activity." [MITRE:tk]
subset: gosubset_prok
synonym: "regulation by symbiont of host excretion " EXACT []
is_a: GO:0044055 ! modulation by symbiont of host system process
is_a: GO:0044062 ! regulation of excretion

[Term]
id: GO:0044062
name: regulation of excretion
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity." [GOC:jl]
is_a: GO:0044057 ! regulation of system process
is_a: GO:0051046 ! regulation of secretion
relationship: regulates GO:0007588 ! excretion

[Term]
id: GO:0044063
name: modulation by symbiont of host neurological system process
namespace: biological_process
def: "The alteration by a symbiont organism of the functioning of a host neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system." [MITRE:tk]
subset: gosubset_prok
synonym: "regulation by symbiont of host neurological system process" EXACT []
is_a: GO:0031644 ! regulation of neurological system process
is_a: GO:0044055 ! modulation by symbiont of host system process

[Term]
id: GO:0044064
name: modulation by symbiont of host respiratory system process
namespace: biological_process
def: "The alteration by a symbiont organism of the functioning of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [MITRE:tk]
subset: gosubset_prok
synonym: "regulation by symbiont of host respiratory system process " EXACT []
is_a: GO:0044055 ! modulation by symbiont of host system process
is_a: GO:0044065 ! regulation of respiratory system process

[Term]
id: GO:0044065
name: regulation of respiratory system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [GOC:jl]
is_a: GO:0043576 ! regulation of respiratory gaseous exchange
is_a: GO:0044057 ! regulation of system process
relationship: regulates GO:0003016 ! respiratory system process

[Term]
id: GO:0044066
name: modification by symbiont of host cell nucleus
namespace: biological_process
def: "The process by which a symbiont organism effects a change in the structure or function of its host cell nucleus." [MITRE:tk]
subset: gosubset_prok
synonym: "modification by symbiont of host nucleus " EXACT []
synonym: "modification of host cell nucleus by symbiont" EXACT []
synonym: "modification of host nucleus by symbiont" EXACT []
is_a: GO:0052043 ! modification by symbiont of host cellular component

[Term]
id: GO:0044067
name: modification by symbiont of host intercellular junctions
namespace: biological_process
def: "The process by which a symbiont organism effects a change in the structure or function of its host intercellular junction, a specialized region of connection between two cells." [MITRE:tk]
subset: gosubset_prok
synonym: "modification of host intercellular junctions by symbiont " EXACT []
is_a: GO:0052043 ! modification by symbiont of host cellular component

[Term]
id: GO:0044068
name: modulation by symbiont of host cellular process
namespace: biological_process
def: "Any process by which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "modulation of host cellular process by symbiont" EXACT []
synonym: "regulation by symbiont of host cellular process " EXACT []
synonym: "regulation of host cellular process by symbiont" EXACT []
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0050794 ! regulation of cellular process

[Term]
id: GO:0044069
name: modification by symbiont of host anion transport
namespace: biological_process
def: "The process by which a symbiont organism modulates the anion transport, the directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells, of its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "modification of host anion transport by symbiont" EXACT []
is_a: GO:0044070 ! regulation of anion transport
is_a: GO:0052038 ! modulation by symbiont of host intracellular transport

[Term]
id: GO:0044070
name: regulation of anion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl]
is_a: GO:0043269 ! regulation of ion transport
relationship: regulates GO:0006820 ! anion transport

[Term]
id: GO:0044071
name: modulation by symbiont of host cell cycle
namespace: biological_process
def: "The process by which a symbiont organism effects a change in its host's cell cycle through direct interactions with the host cell macromolecular machinery." [MITRE:tk]
subset: gosubset_prok
synonym: "modification by symbiont of host cell cycle " EXACT []
synonym: "modulation of host cell cycle by symbiont" EXACT []
synonym: "regulation by symbiont of host cell cycle " EXACT []
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0051726 ! regulation of cell cycle

[Term]
id: GO:0044072
name: negative regulation by symbiont of host cell cycle
namespace: biological_process
def: "The process by which a symbiont organism stops, prevents or reduces the rate or extent of its host's progression through its cell cycle via direct interactions with the host cell macromolecular machinery." [MITRE:tk]
subset: gosubset_prok
is_a: GO:0044071 ! modulation by symbiont of host cell cycle
is_a: GO:0045786 ! negative regulation of cell cycle

[Term]
id: GO:0044073
name: modulation by symbiont of host translation
namespace: biological_process
def: "The process in which a symbiont organism effects a change in translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "modification by symbiont of host translation" EXACT []
synonym: "modulation of host translation by symbiont" EXACT []
synonym: "regulation by symbiont of host translation" EXACT []
is_a: GO:0006417 ! regulation of translation
is_a: GO:0044068 ! modulation by symbiont of host cellular process

[Term]
id: GO:0044074
name: negative regulation by symbiont of host translation
namespace: biological_process
def: "The process in which a symbiont organism activates or increases the frequency, rate or extent of translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "negative regulation of host translation by symbiont" EXACT []
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0044073 ! modulation by symbiont of host translation

[Term]
id: GO:0044075
name: modulation by symbiont of host vacuole organization
namespace: biological_process
def: "Any process by which a symbiont organism modulates the frequency, rate or extent of vacuole organization in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "modulation by symbiont of host vacuole biogenesis" RELATED [GOC:mah]
synonym: "modulation by symbiont of host vacuole organisation" EXACT [GOC:mah]
synonym: "modulation of host vacuole organization by symbiont" EXACT [GOC:mah]
synonym: "regulation by symbiont of host vacuole organization" EXACT [GOC:mah]
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0044088 ! regulation of vacuole organization

[Term]
id: GO:0044076
name: positive regulation by symbiont of host vacuole organization
namespace: biological_process
def: "The process in which a symbiont organism activates or increases the frequency, rate or extent of vacuole organization in its host organism." [MITRE:tk]
synonym: "positive regulation by symbiont of host vacuole biogenesis" RELATED [GOC:mah]
synonym: "positive regulation by symbiont of host vacuole organisation" EXACT [GOC:mah]
synonym: "positive regulation of host vacuole organization by symbiont" EXACT []
is_a: GO:0044075 ! modulation by symbiont of host vacuole organization
is_a: GO:0044090 ! positive regulation of vacuole organization

[Term]
id: GO:0044077
name: modulation by symbiont of host receptor-mediated endocytosis
namespace: biological_process
def: "The process by which a symbiont organism modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "modulation of host receptor-mediated endocytosis by symbiont" EXACT []
synonym: "regulation by symbiont of host receptor-mediated endocytosis" EXACT []
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0048259 ! regulation of receptor-mediated endocytosis

[Term]
id: GO:0044078
name: positive regulation by symbiont of host receptor-mediated endocytosis
namespace: biological_process
def: "Any process by which a symbiont organism activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "positive regulation of host receptor-mediated endocytosis by symbiont" EXACT []
is_a: GO:0044077 ! modulation by symbiont of host receptor-mediated endocytosis
is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis

[Term]
id: GO:0044079
name: modulation by symbiont of host neurotransmitter secretion
namespace: biological_process
def: "Any process by which a symbiont organism modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell or group of cells in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "modification by symbiont of host neurotransmitter secretion" EXACT []
synonym: "modulation of host neurotransmitter secretion by symbiont" EXACT []
synonym: "regulation by symbiont of host neurotransmitter secretion" EXACT []
is_a: GO:0044063 ! modulation by symbiont of host neurological system process
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0046928 ! regulation of neurotransmitter secretion

[Term]
id: GO:0044080
name: modulation by symbiont of host cGMP-mediated signal transduction
namespace: biological_process
def: "Any process by which a symbiont organism modulates the rate, frequency or extent of cGMP-mediated signaling in its host organism. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [MITRE:tk]
subset: gosubset_prok
synonym: "modulation by symbiont of host cGMP-mediated signal transduction pathway" EXACT []
synonym: "modulation by symbiont of host cGMP-mediated signaling" EXACT []
synonym: "modulation by symbiont of host cGMP-mediated signalling" EXACT []
synonym: "modulation of host cGMP-mediated signal transduction by symbiont" EXACT []
synonym: "regulation by symbiont of host cGMP-mediated signal transduction" EXACT []
is_a: GO:0010752 ! regulation of cGMP-mediated signaling
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway

[Term]
id: GO:0044081
name: modulation by symbiont of host nitric oxide-mediated signal transduction
namespace: biological_process
def: "Any process by which a symbiont organism modulates the rate, frequency or extent of nitric oxide mediated signal transduction in its host organism. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [MITRE:tk]
subset: gosubset_prok
synonym: "modulation by symbiont of host nitric oxide mediated signal transduction" EXACT []
synonym: "modulation of host nitric oxide-mediated signal transduction by symbiont" EXACT []
synonym: "modulation of host nitric oxide-mediated signaling by symbiont" EXACT []
synonym: "modulation of host nitric oxide-mediated signalling by symbiont" EXACT []
synonym: "regulation by symbiont of host nitric oxide-mediated signal transduction" EXACT []
is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway

[Term]
id: GO:0044082
name: modulation by symbiont of host small GTPase mediated signal transduction
namespace: biological_process
def: "Any process by which a symbiont organism modulates the frequency, rate or extent of small GTPase mediated signal transduction in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "modulation of host small GTPase mediated signal transduction by symbiont" EXACT []
synonym: "regulation by symbiont of host small GTPase mediated signal transduction" EXACT []
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway

[Term]
id: GO:0044083
name: modulation by symbiont of host Rho protein signal transduction
namespace: biological_process
def: "Any process by which a symbiont organism modulates the frequency, rate or extent of Rho protein signal transduction in its host organism." [MITRE:tk]
subset: gosubset_prok
synonym: "modulation by symbiont of host Rho protein mediated signal transduction" EXACT []
synonym: "modulation by symbiont of host Rho protein-mediated signal transduction" EXACT []
synonym: "modulation of host Rho protein signal transduction by symbiont" EXACT []
synonym: "modulation of host Rho protein signaling by symbiont" EXACT []
synonym: "modulation of host Rho protein signalling by symbiont" EXACT []
synonym: "regulation by symbiont of host Rho protein signal transduction" EXACT []
is_a: GO:0035023 ! regulation of Rho protein signal transduction
is_a: GO:0044082 ! modulation by symbiont of host small GTPase mediated signal transduction

[Term]
id: GO:0044084
name: host cell membrane pore complex
namespace: cellular_component
def: "Any small opening in a host cell membrane that allows the passage of gases and/or liquids, composed of host proteins." [MITRE:tk]
subset: gosubset_prok
synonym: "pore complex in host cell membrane" EXACT []
is_a: GO:0033644 ! host cell membrane

[Term]
id: GO:0044085
name: cellular component biogenesis
namespace: biological_process
def: "The process by which a cellular component is synthesized, aggregates, and bonds together. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]
subset: gosubset_prok
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0044087
name: regulation of cellular component biogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cellular component biogenesis, the process by which a cellular component is synthesized, aggregates, and bonds together." [GOC:jl]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0044088
name: regulation of vacuole organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah]
synonym: "regulation of vacuole biogenesis" RELATED [GOC:mah]
synonym: "regulation of vacuole organisation" EXACT [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0007033 ! vacuole organization

[Term]
id: GO:0044089
name: positive regulation of cellular component biogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, the process by which a cellular component is synthesized, aggregates, and bonds together." [GOC:jl]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0044090
name: positive regulation of vacuole organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah]
synonym: "positive regulation of vacuole biogenesis" RELATED [GOC:mah]
synonym: "positive regulation of vacuole organisation" EXACT [GOC:mah]
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0044088 ! regulation of vacuole organization
relationship: positively_regulates GO:0007033 ! vacuole organization

[Term]
id: GO:0044091
name: membrane biogenesis
namespace: biological_process
def: "The process by which a membrane is synthesized, aggregates, and bonds together." [GOC:jl]
is_a: GO:0009987 ! cellular process
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0044092
name: negative regulation of molecular function
namespace: biological_process
def: "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0044093
name: positive regulation of molecular function
namespace: biological_process
def: "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0044094
name: host cell nuclear part
namespace: cellular_component
def: "Any constituent part of a host cell's nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:ecd]
subset: gosubset_prok
is_a: GO:0033646 ! host intracellular part
relationship: part_of GO:0042025 ! host cell nucleus

[Term]
id: GO:0044095
name: host cell nucleoplasm
namespace: cellular_component
def: "That part of a host cell's nuclear content other than the chromosomes or the nucleolus. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:ecd]
subset: gosubset_prok
is_a: GO:0044094 ! host cell nuclear part

[Term]
id: GO:0044096
name: type IV pilus
namespace: cellular_component
def: "A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers." [GOC:pamgo_curators]
subset: gosubset_prok
synonym: "TFP" EXACT []
synonym: "type 4 pilus" EXACT []
synonym: "type IV fimbriae" EXACT []
is_a: GO:0009289 ! pilus

[Term]
id: GO:0044097
name: secretion by the type IV secretion system
namespace: biological_process
def: "The controlled release of proteins or DNA by a cell, via the type IV secretion system." [GOC:pamgo_curators]
synonym: "secretion via the type IV secretion system" EXACT []
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0044098
name: DNA secretion by the type IV secretion system
namespace: biological_process
def: "The controlled release of DNA by a cell, via the type IV secretion system." [GOC:pamgo_curators]
synonym: "DNA secretion via the type IV secretion system" EXACT []
is_a: GO:0044097 ! secretion by the type IV secretion system

[Term]
id: GO:0044099
name: polar tube
namespace: cellular_component
def: "A highly specialized structure unique to microsporidia that is required for host cell invasion. In the spore, the polar tube is connected at the anterior end, and then coils around the sporoplasm. Upon appropriate environmental stimulation, the polar tube rapidly discharges out of the spore, pierces a cell membrane and serves as a conduit for sporoplasm passage into the new host cell." [GOC:mf, PMID:12076771, PMID:9723921]
is_a: GO:0044464 ! cell part

[Term]
id: GO:0044100
name: sporoplasm
namespace: cellular_component
def: "The complex infective apparatus corresponding to the central mass of cytoplasm within a spore that is injected into a host cell by various parasitic microorganisms." [GOC:mf, PMID:12076771, PMID:16004371, PMID:9723921]
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0044101
name: (R)-citramalyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-citramalyl-CoA = pyruvate + acetyl-CoA." [GOC:jl, IMG:03307]
subset: gosubset_prok
synonym: "Ccl" RELATED []
synonym: "R-citramalyl-CoA lyase activity" EXACT []
xref: EC:4.1.3.-
xref: IMG:03307
xref: MetaCyc:CPLX-7553
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0044102
name: purine deoxyribosyltransferase activity
namespace: molecular_function
def: "Catalysis of deoxyribose exchange between purine deoxyribonucleoside as a donor and purine base as an acceptor." [GOC:jl, IMG:03313, PMID:11836245]
subset: gosubset_prok
synonym: "PTD" RELATED []
synonym: "purine 2'-deoxyribosyltransferase activity" EXACT []
xref: EC:2.4.2.-
xref: IMG:03313
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0044103
name: L-arabinose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+." [GOC:jl, IMG:03333]
subset: gosubset_prok
xref: EC:1.1.1.-
xref: IMG:03333
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0044104
name: 2,5-dioxopentanoate dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dioxopentanoate + NAD+ + H2O = 2-oxoglutarate + NADH + H+." [IMG:03338, PMID:16835232, PMID:17202142]
subset: gosubset_prok
xref: EC:1.2.1.-
xref: IMG:03338
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0044105
name: L-xylulose reductase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: xylitol + NAD+ = L-xylulose + NADH + H+." [IMG:03341, PMID:14736891]
subset: gosubset_prok
xref: EC:1.1.1.-
xref: IMG:03341
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0044106
name: cellular amine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl]
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process

[Term]
id: GO:0044107
name: cellular alcohol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells." [GOC:jl]
is_a: GO:0006066 ! alcohol metabolic process

[Term]
id: GO:0044108
name: cellular alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, carried out at the level of an individual cell." [GOC:jl]
is_a: GO:0044107 ! cellular alcohol metabolic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0044109
name: cellular alcohol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, occurring at the level of the individual cell." [GOC:jl]
is_a: GO:0044107 ! cellular alcohol metabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0044110
name: growth during symbiotic interaction
namespace: biological_process
def: "The increase in size or mass of an organism occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development during symbiotic interaction ; GO:0052171'. See also 'development during symbiotic interaction ; GO:0044111'.
subset: gosubset_prok
is_a: GO:0040007 ! growth
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0044111
name: development during symbiotic interaction
namespace: biological_process
def: "The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development during symbiotic interaction ; GO:0052171'. See also 'growth during symbiotic interaction ; GO:0044110'.
subset: gosubset_prok
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0044112
name: growth in other organism during symbiotic interaction
namespace: biological_process
def: "The increase in size or mass of an organism, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GOC:cc, GOC:jl]
comment: This term partially replaces the obsolete term 'growth or development in other organism during symbiotic interaction ; GO:0051831'. See also 'development in other organism during symbiotic interaction ; GO:0044113'.
is_a: GO:0044110 ! growth during symbiotic interaction

[Term]
id: GO:0044113
name: development in other organism during symbiotic interaction
namespace: biological_process
def: "The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GO:jl, GOC:cc]
comment: This term partially replaces the obsolete term 'growth or development in other organism during symbiotic interaction ; GO:0051831'. See also 'growth in other organism during symbiotic interaction ; GO:0044112'.
subset: gosubset_prok
is_a: GO:0044111 ! development during symbiotic interaction

[Term]
id: GO:0044114
name: development of symbiont in host
namespace: biological_process
def: "The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host ; GO:0044412'. See also 'growth of symbiont in host ; GO:0044117'.
subset: gosubset_prok
is_a: GO:0044115 ! development of symbiont during interaction with host

[Term]
id: GO:0044115
name: development of symbiont during interaction with host
namespace: biological_process
def: "The progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont during interaction with host ; GO:0052108'. See also 'growth of symbiont during interaction with host ; GO:0044116'.
subset: gosubset_prok
is_a: GO:0044111 ! development during symbiotic interaction

[Term]
id: GO:0044116
name: growth of symbiont during interaction with host
namespace: biological_process
def: "The increase in size or mass of an organism, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont during interaction with host ; GO:0052108'. See also 'development of symbiont during interaction with host ; GO:0044115'.
subset: gosubset_prok
is_a: GO:0044110 ! growth during symbiotic interaction

[Term]
id: GO:0044117
name: growth of symbiont in host
namespace: biological_process
def: "The increase in size or mass of an organism, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host ; GO:0044412'. See also 'development of symbiont in host ; GO:0044114'.
subset: gosubset_prok
is_a: GO:0044116 ! growth of symbiont during interaction with host

[Term]
id: GO:0044118
name: development of symbiont in host cell
namespace: biological_process
def: "The progression of the symbiont from an initial condition to a later condition, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host cell ; GO:0075065'. See also 'growth of symbiont in host cell ; GO:0044119'.
subset: gosubset_prok
is_a: GO:0044114 ! development of symbiont in host

[Term]
id: GO:0044119
name: growth of symbiont in host cell
namespace: biological_process
def: "The increase in size or mass of symbiont, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host cell ; GO:0075065'. See also 'development of symbiont in host cell ; GO:0044118'.
subset: gosubset_prok
is_a: GO:0044117 ! growth of symbiont in host

[Term]
id: GO:0044120
name: development of symbiont in host organelle
namespace: biological_process
def: "The progression of the symbiont from an initial condition to a later condition, occurring in its host's organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host organelle ; GO:0075066'. See also 'growth of symbiont in host organelle ; GO:0044121'.
subset: gosubset_prok
is_a: GO:0044118 ! development of symbiont in host cell

[Term]
id: GO:0044121
name: growth of symbiont in host organelle
namespace: biological_process
def: "The increase in size or mass of a symbiont, occurring in its host's organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host organelle ; GO:0075066'. See also 'development of symbiont in host organelle ; GO:0044120'.
subset: gosubset_prok
is_a: GO:0044119 ! growth of symbiont in host cell

[Term]
id: GO:0044122
name: development of symbiont in host vascular tissue
namespace: biological_process
def: "The progression of the symbiont from an initial condition to a later condition, occurring in its host's vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host organelle ; GO:0075066'. See also 'growth of symbiont in host vascular tissue ; GO:0044123'.
subset: gosubset_prok
is_a: GO:0044114 ! development of symbiont in host

[Term]
id: GO:0044123
name: growth of symbiont in host vascular tissue
namespace: biological_process
def: "The increase in size or mass of symbiont, occurring in its host's vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host organelle ; GO:0075066'. See also 'development of symbiont in host vascular tissue ; GO:0044122'.
subset: gosubset_prok
is_a: GO:0044117 ! growth of symbiont in host

[Term]
id: GO:0044124
name: development of symbiont in host intercellular space
namespace: biological_process
def: "The progression of the symbiont from an initial condition to a later condition, occurring in its host's intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host intercellular space ; GO:0075067'. See also 'growth of symbiont in host intercellular space ; GO:0044125'.
subset: gosubset_prok
is_a: GO:0044114 ! development of symbiont in host

[Term]
id: GO:0044125
name: growth of symbiont in host intercellular space
namespace: biological_process
def: "The increase in size or mass of symbiont, occurring in its host's intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont in host intercellular space ; GO:0075067'. See also 'development of symbiont in host intercellular space ; GO:0044124'.
subset: gosubset_prok
is_a: GO:0044117 ! growth of symbiont in host

[Term]
id: GO:0044126
name: regulation of growth of symbiont in host
namespace: biological_process
def: "Any process by which the symbiont regulates the increase in its size or mass within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'regulation of growth or development of symbiont in host ; GO:0033665'. See also 'regulation of development of symbiont in host ; GO:0044127'.
subset: gosubset_prok
is_a: GO:0040008 ! regulation of growth
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
relationship: regulates GO:0044117 ! growth of symbiont in host

[Term]
id: GO:0044127
name: regulation of development of symbiont in host
namespace: biological_process
def: "Any process by which the symbiont regulates its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'regulation of growth or development of symbiont in host ; GO:0033665'. See also 'regulation of growth of symbiont in host ; GO:0044126'.
subset: gosubset_prok
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0044114 ! development of symbiont in host

[Term]
id: GO:0044128
name: positive regulation of growth of symbiont in host
namespace: biological_process
def: "Any process by which the symbiont activates, maintains or increases its size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont in host ; GO:0033666'. See also 'positive regulation of development of symbiont in host ; GO:0044129'.
subset: gosubset_prok
is_a: GO:0044126 ! regulation of growth of symbiont in host
is_a: GO:0044148 ! positive regulation of growth of symbiont during interaction with host
relationship: positively_regulates GO:0044117 ! growth of symbiont in host

[Term]
id: GO:0044129
name: positive regulation of development of symbiont in host
namespace: biological_process
def: "Any process by which the symbiont activates or maintains its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont in host ; GO:0033666'. See also 'positive regulation of growth of symbiont in host ; GO:0044128'.
subset: gosubset_prok
is_a: GO:0044127 ! regulation of development of symbiont in host
is_a: GO:0044149 ! positive regulation of development of symbiont during interaction with host
relationship: positively_regulates GO:0044114 ! development of symbiont in host

[Term]
id: GO:0044130
name: negative regulation of growth of symbiont in host
namespace: biological_process
def: "Any process by which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont in host ; GO:0033667'. See also 'negative regulation of development of symbiont in host ; GO:0044131'.
subset: gosubset_prok
is_a: GO:0044126 ! regulation of growth of symbiont in host
is_a: GO:0044146 ! negative regulation of growth of symbiont during interaction with host
relationship: negatively_regulates GO:0044117 ! growth of symbiont in host

[Term]
id: GO:0044131
name: negative regulation of development of symbiont in host
namespace: biological_process
def: "Any process by which the symbiont stops, prevents or reduces its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont in host ; GO:0033667'. See also 'negative regulation of growth of symbiont in host ; GO:0044130'.
subset: gosubset_prok
is_a: GO:0044127 ! regulation of development of symbiont in host
is_a: GO:0044147 ! negative regulation of development of symbiont during interaction with host
relationship: negatively_regulates GO:0044114 ! development of symbiont in host

[Term]
id: GO:0044132
name: development of symbiont on or near host
namespace: biological_process
def: "The progression of a symbiont from an initial condition to a later condition, within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host ; GO:0044408'. See also 'growth of symbiont on or near host ; GO:0044133'.
subset: gosubset_prok
is_a: GO:0044115 ! development of symbiont during interaction with host

[Term]
id: GO:0044133
name: growth of symbiont on or near host
namespace: biological_process
def: "The increase in size or mass of a symbiont within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host ; GO:0044408'. See also 'development of symbiont on or near host ; GO:0044132'.
subset: gosubset_prok
is_a: GO:0044116 ! growth of symbiont during interaction with host

[Term]
id: GO:0044134
name: development of symbiont on or near host phyllosphere
namespace: biological_process
def: "The progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host phyllosphere ; GO:0075013'. See also 'growth of symbiont on or near host phyllosphere ; GO:0044135'.
is_a: GO:0044132 ! development of symbiont on or near host

[Term]
id: GO:0044135
name: growth of symbiont on or near host phyllosphere
namespace: biological_process
def: "The increase in size or mass of symbiont occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host phyllosphere ; GO:0075013'. See also 'development of symbiont on or near host phyllosphere ; GO:0044134'.
is_a: GO:0044133 ! growth of symbiont on or near host

[Term]
id: GO:0044136
name: development of symbiont on or near host rhizosphere
namespace: biological_process
def: "The progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host rhizosphere ; GO:0075014'. See also 'growth of symbiont on or near host rhizosphere ; GO:0044137'.
subset: gosubset_prok
is_a: GO:0044132 ! development of symbiont on or near host

[Term]
id: GO:0044137
name: growth of symbiont on or near host rhizosphere
namespace: biological_process
def: "The increase in size or mass of symbiont occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'growth or development of symbiont on or near host rhizosphere ; GO:0075014'. See also 'development of symbiont on or near host rhizosphere ; GO:0044136'.
subset: gosubset_prok
is_a: GO:0044133 ! growth of symbiont on or near host

[Term]
id: GO:0044138
name: modulation of development of symbiont on or near host
namespace: biological_process
def: "Any process by which the symbiont regulates its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont on or near host ; GO:0075305'. See also 'modulation of growth of symbiont on or near host ; GO:0044139'.
subset: gosubset_prok
is_a: GO:0044145 ! modulation of development of symbiont during interaction with host
relationship: regulates GO:0044132 ! development of symbiont on or near host

[Term]
id: GO:0044139
name: modulation of growth of symbiont on or near host
namespace: biological_process
def: "Any process by which the symbiont regulates the increase in its size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont on or near host ; GO:0075305'. See also 'modulation of development of symbiont on or near host ; GO:0044138'.
subset: gosubset_prok
is_a: GO:0044144 ! modulation of growth of symbiont during interaction with host
relationship: regulates GO:0044133 ! growth of symbiont on or near host

[Term]
id: GO:0044140
name: negative regulation of growth of symbiont on or near host surface
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the increase in the symbiont's size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont on or near host surface ; GO:0075309'. See also 'negative regulation of development of symbiont on or near host surface ; GO:0044141'.
subset: gosubset_prok
is_a: GO:0044139 ! modulation of growth of symbiont on or near host
is_a: GO:0044146 ! negative regulation of growth of symbiont during interaction with host
relationship: negatively_regulates GO:0044133 ! growth of symbiont on or near host

[Term]
id: GO:0044141
name: negative regulation of development of symbiont on or near host surface
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the symbiont's progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont on or near host surface ; GO:0075309'. See also 'negative regulation of growth of symbiont on or near host surface ; GO:0044140'.
subset: gosubset_prok
is_a: GO:0044138 ! modulation of development of symbiont on or near host
is_a: GO:0044147 ! negative regulation of development of symbiont during interaction with host
relationship: negatively_regulates GO:0044132 ! development of symbiont on or near host

[Term]
id: GO:0044142
name: positive regulation of growth of symbiont on or near host surface
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the symbiont's increase in size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont on or near host surface ; GO:0075337'. See also 'positive regulation of development of symbiont on or near host surface ; GO:0044143'.
subset: gosubset_prok
is_a: GO:0044139 ! modulation of growth of symbiont on or near host
is_a: GO:0044148 ! positive regulation of growth of symbiont during interaction with host
relationship: positively_regulates GO:0044133 ! growth of symbiont on or near host

[Term]
id: GO:0044143
name: positive regulation of development of symbiont on or near host surface
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the symbiont's progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont on or near host surface ; GO:0075337'. See also 'positive regulation of growth of symbiont on or near host surface ; GO:0044142'.
subset: gosubset_prok
is_a: GO:0044138 ! modulation of development of symbiont on or near host
is_a: GO:0044149 ! positive regulation of development of symbiont during interaction with host
relationship: positively_regulates GO:0044132 ! development of symbiont on or near host

[Term]
id: GO:0044144
name: modulation of growth of symbiont during interaction with host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont during interaction with host ; GO:0075338'. See also 'modulation of development of symbiont during interaction with host ; GO:0044145'.
subset: gosubset_prok
is_a: GO:0040008 ! regulation of growth
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
relationship: regulates GO:0044116 ! growth of symbiont during interaction with host

[Term]
id: GO:0044145
name: modulation of development of symbiont during interaction with host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont during interaction with host ; GO:0075338'. See also 'modulation of growth of symbiont during interaction with host ; GO:0044144'.
subset: gosubset_prok
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0044115 ! development of symbiont during interaction with host

[Term]
id: GO:0044146
name: negative regulation of growth of symbiont during interaction with host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont during interaction with host ; GO:0075340'. See also 'negative regulation of development of symbiont during interaction with host ; GO:0044147'.
subset: gosubset_prok
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0044144 ! modulation of growth of symbiont during interaction with host
is_a: GO:0045926 ! negative regulation of growth
relationship: negatively_regulates GO:0044116 ! growth of symbiont during interaction with host

[Term]
id: GO:0044147
name: negative regulation of development of symbiont during interaction with host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont during interaction with host ; GO:0075340'. See also 'negative regulation of growth of symbiont during interaction with host ; GO:0044146'.
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0044145 ! modulation of development of symbiont during interaction with host
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0044115 ! development of symbiont during interaction with host

[Term]
id: GO:0044148
name: positive regulation of growth of symbiont during interaction with host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont during interaction with host ; GO:0075339'. See also 'positive regulation of development of symbiont during interaction with host ; GO:0044149'.
subset: gosubset_prok
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0044144 ! modulation of growth of symbiont during interaction with host
is_a: GO:0045927 ! positive regulation of growth
relationship: positively_regulates GO:0044116 ! growth of symbiont during interaction with host

[Term]
id: GO:0044149
name: positive regulation of development of symbiont during interaction with host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]
comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont during interaction with host ; GO:0075339'. See also 'positive regulation of growth of symbiont during interaction with host ; GO:0044148'.
subset: gosubset_prok
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0044145 ! modulation of development of symbiont during interaction with host
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0044115 ! development of symbiont during interaction with host

[Term]
id: GO:0044150
name: development of organism on or near symbiont surface
namespace: biological_process
def: "The progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl]
subset: gosubset_prok
is_a: GO:0044152 ! development on or near surface of other organism during symbiotic interaction

[Term]
id: GO:0044151
name: growth of organism on or near symbiont surface
namespace: biological_process
def: "The increase in size or mass of an organism occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl]
comment: This term partially replaces the obsolete term 'growth or development of organism on or near symbiont surface ; GO:0051857'. See also 'development of organism on or near symbiont surface ; GO:0044150'.
subset: gosubset_prok
is_a: GO:0044153 ! growth on or near surface of other organism during symbiotic interaction

[Term]
id: GO:0044152
name: development on or near surface of other organism during symbiotic interaction
namespace: biological_process
def: "The progression of an organism from an initial condition to a later condition, occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc, GOC:jl]
comment: This term partially replaces the obsolete term 'growth or development on or near surface of other organism during symbiotic interaction ; GO:0051827'. See also 'growth on or near surface of other organism during symbiotic interaction ; GO:0044153'.
subset: gosubset_prok
is_a: GO:0044111 ! development during symbiotic interaction

[Term]
id: GO:0044153
name: growth on or near surface of other organism during symbiotic interaction
namespace: biological_process
def: "The increase in size or mass of an organism occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc, GOC:jl]
comment: This term partially replaces the obsolete term 'growth or development on or near surface of other organism during symbiotic interaction ; GO:0051827'. See also 'development on or near surface of other organism during symbiotic interaction ; GO:0044152'.
subset: gosubset_prok
is_a: GO:0044110 ! growth during symbiotic interaction

[Term]
id: GO:0044154
name: histone H3-K14 acetylation
namespace: biological_process
def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone." [GOC:jl, GOC:lb, PMID:17194708]
synonym: "histone H3 acetylation at K14" EXACT []
synonym: "histone H3K14 acetylation" EXACT []
is_a: GO:0043966 ! histone H3 acetylation

[Term]
id: GO:0044155
name: host caveola
namespace: cellular_component
def: "A small pit, depression, or invagination, such as any of the minute pits or incuppings of the host cell membrane formed during pinocytosis, that communicates with the outside of a host cell and extends inward, indenting the host cytoplasm and the host cell membrane. Such caveolae may be pinched off to form free vesicles within the host cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:rph]
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0033644 ! host cell membrane

[Term]
id: GO:0044156
name: host cell junction
namespace: cellular_component
def: "A plasma membrane part that forms a specialized region of connection between two host cells or between a host cell and the host extracellular matrix. At a host cell junction, anchoring proteins extend through the host plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:rph]
is_a: GO:0033643 ! host cell part
relationship: part_of GO:0020002 ! host cell plasma membrane

[Term]
id: GO:0044157
name: host cell projection
namespace: cellular_component
def: "A prolongation or process extending from a host cell, e.g. a flagellum or axon." [GOC:rph]
subset: gosubset_prok
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0044158
name: host cell wall
namespace: cellular_component
def: "The rigid or semi-rigid envelope lying outside the host cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan." [GOC:rph]
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0044159
name: host thylakoid
namespace: cellular_component
def: "A membranous cellular structure within the host cell that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the host plasma membrane. In eukaryotic host cells they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:rph]
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044160
name: host thylakoid membrane
namespace: cellular_component
def: "The pigmented membrane of any host thylakoid." [GOC:rph]
is_a: GO:0033644 ! host cell membrane
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0044159 ! host thylakoid

[Term]
id: GO:0044161
name: host cell cytoplasmic vesicle
namespace: cellular_component
def: "A vesicle formed of membrane or protein, found in the cytoplasm of a host cell." [GOC:rph]
is_a: GO:0033647 ! host intracellular organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044162
name: host cell cytoplasmic vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a host cell cytoplasmic vesicle." [GOC:rph]
is_a: GO:0033644 ! host cell membrane
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0044161 ! host cell cytoplasmic vesicle

[Term]
id: GO:0044163
name: host cytoskeleton
namespace: cellular_component
def: "Any of the various filamentous elements that form the internal framework of host cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the host cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the host cell. The various elements of the host cytoskeleton not only serve in the maintenance of host cellular shape but also have roles in other host cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:rph]
is_a: GO:0033646 ! host intracellular part

[Term]
id: GO:0044164
name: host cell cytosol
namespace: cellular_component
def: "The part of the host cell cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:jl]
subset: gosubset_prok
synonym: "host cytosol" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044165
name: host cell endoplasmic reticulum
namespace: cellular_component
def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [GOC:jl]
subset: gosubset_prok
synonym: "host endoplasmic reticulum" EXACT []
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044166
name: host cell endoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the host cell endoplasmic reticulum." [GOC:jl]
subset: gosubset_prok
synonym: "host endoplasmic reticulum lumen" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0044165 ! host cell endoplasmic reticulum

[Term]
id: GO:0044167
name: host cell endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the host cell endoplasmic reticulum." [GOC:jl]
subset: gosubset_prok
synonym: "host endoplasmic reticulum membrane" EXACT []
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0033645 ! host cell endomembrane system
relationship: part_of GO:0044165 ! host cell endoplasmic reticulum

[Term]
id: GO:0044168
name: host cell rough endoplasmic reticulum
namespace: cellular_component
def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host rough ER has ribosomes adhering to the outer surface." [GOC:jl]
subset: gosubset_prok
synonym: "host rough endoplasmic reticulum" EXACT []
is_a: GO:0044165 ! host cell endoplasmic reticulum

[Term]
id: GO:0044169
name: host cell rough endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the host cell rough endoplasmic reticulum." [GOC:jl]
subset: gosubset_prok
synonym: "host rough endoplasmic reticulum membrane" EXACT []
is_a: GO:0044167 ! host cell endoplasmic reticulum membrane
relationship: part_of GO:0044168 ! host cell rough endoplasmic reticulum

[Term]
id: GO:0044170
name: host cell smooth endoplasmic reticulum
namespace: cellular_component
def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host smooth ER has no ribosomes adhering to the outer surface." [GOC:jl]
subset: gosubset_prok
synonym: "host smooth endoplasmic reticulum" EXACT []
is_a: GO:0044165 ! host cell endoplasmic reticulum

[Term]
id: GO:0044171
name: host cell smooth endoplasmic reticulum membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the host cell smooth endoplasmic reticulum." [GOC:jl]
subset: gosubset_prok
synonym: "host smooth endoplasmic reticulum membrane" EXACT []
is_a: GO:0044167 ! host cell endoplasmic reticulum membrane
relationship: part_of GO:0044170 ! host cell smooth endoplasmic reticulum

[Term]
id: GO:0044172
name: host cell endoplasmic reticulum-Golgi intermediate compartment
namespace: cellular_component
def: "A complex system of membrane-bounded compartments located between host cell endoplasmic reticulum (ER) and the host Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport." [GOC:jl]
subset: gosubset_prok
synonym: "host cell ER-Golgi intermediate compartment" EXACT []
synonym: "host ER-Golgi intermediate compartment" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044173
name: host cell endoplasmic reticulum-Golgi intermediate compartment membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments of the host cell ER-Golgi intermediate compartment system." [GOC:jl]
subset: gosubset_prok
synonym: "host cell ER-Golgi intermediate compartment membrane" EXACT []
synonym: "host endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT []
synonym: "host ER-Golgi intermediate compartment membrane" EXACT []
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0044172 ! host cell endoplasmic reticulum-Golgi intermediate compartment

[Term]
id: GO:0044174
name: host cell endosome
namespace: cellular_component
def: "A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to host cell lysosomes for degradation." [GOC:jl]
subset: gosubset_prok
synonym: "host endosome" EXACT []
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044175
name: host cell endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a host cell endosome." [GOC:jl]
synonym: "host endosome membrane" EXACT []
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0044174 ! host cell endosome

[Term]
id: GO:0044176
name: host cell filopodium
namespace: cellular_component
def: "Thin, stiff protrusion extended by the leading edge of a motile host cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward." [GOC:jl]
subset: gosubset_prok
synonym: "host filopodium" EXACT []
is_a: GO:0044157 ! host cell projection

[Term]
id: GO:0044177
name: host cell Golgi apparatus
namespace: cellular_component
def: "A compound membranous cytoplasmic organelle of eukaryotic host cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl]
subset: gosubset_prok
synonym: "host Golgi apparatus" EXACT []
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044178
name: host cell Golgi membrane
namespace: cellular_component
def: "The lipid bilayer surrounding any of the compartments of the host cell Golgi apparatus." [GOC:jl]
subset: gosubset_prok
synonym: "host Golgi membrane" EXACT []
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0033645 ! host cell endomembrane system
relationship: part_of GO:0044177 ! host cell Golgi apparatus

[Term]
id: GO:0044179
name: hemolysis of cells in other organism
namespace: biological_process
def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another." [GOC:jl]
subset: gosubset_prok
synonym: "hemolysis of erythrocytes in other organism" EXACT []
synonym: "hemolysis of RBCs in other organism" EXACT []
synonym: "hemolysis of red blood cells in other organism" EXACT []
is_a: GO:0051715 ! cytolysis of cells of another organism

[Term]
id: GO:0044180
name: filamentous growth of a unicellular organism
namespace: biological_process
def: "The process by which a unicellular organism grows in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009]
is_a: GO:0030447 ! filamentous growth

[Term]
id: GO:0044181
name: filamentous growth of a multicellular organism
namespace: biological_process
def: "The process by which a multicellular organism grows in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009]
is_a: GO:0030447 ! filamentous growth
is_a: GO:0060560 ! developmental growth involved in morphogenesis

[Term]
id: GO:0044182
name: filamentous growth of a population of unicellular organisms
namespace: biological_process
def: "The process by which a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009]
is_a: GO:0030447 ! filamentous growth

[Term]
id: GO:0044183
name: protein binding involved in protein folding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding." [GOC:mtg_cambridge_2009]
synonym: "chaperone activity" BROAD []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0044184
name: host cell late endosome
namespace: cellular_component
def: "A prelysosomal endocytic organelle differentiated from host early endosomes by lower lumenal pH and different protein composition. Host late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044174 ! host cell endosome

[Term]
id: GO:0044185
name: host cell late endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a host cell late endosome." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044175 ! host cell endosome membrane
relationship: part_of GO:0044184 ! host cell late endosome

[Term]
id: GO:0044186
name: host cell lipid particle
namespace: cellular_component
def: "Any particle of coalesced lipids in the cytoplasm of a host cell. May include associated proteins." [GOC:jl]
subset: gosubset_prok
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044187
name: host cell lysosome
namespace: cellular_component
def: "A small lytic vacuole that has cell cycle-independent morphology and is found in most host animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and host cell lysosomes have a great variety of morphologies and functions." [GOC:jl]
subset: gosubset_prok
is_a: GO:0033648 ! host intracellular membrane-bounded organelle
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044188
name: host cell lysosomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding the host cell lysosome and separating its contents from the host cell cytoplasm." [GOC:jl]
subset: gosubset_prok
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0044187 ! host cell lysosome

[Term]
id: GO:0044189
name: host cell microsome
namespace: cellular_component
def: "Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic host cells are homogenized and that sediment on centrifugation at 100000 g." [GOC:jl]
subset: gosubset_prok
synonym: "host cell microsomal membrane " EXACT []
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0044190
name: host cell mitochondrial envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the host cell mitochondrion and separating its contents from the host cell cytoplasm; includes the intermembrane space." [GOC:jl]
subset: gosubset_prok
is_a: GO:0033655 ! host cell cytoplasm part
relationship: part_of GO:0033650 ! host cell mitochondrion

[Term]
id: GO:0044191
name: host cell mitochondrial membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the host cell mitochondrion and form the host cell mitochondrial envelope." [GOC:jl]
subset: gosubset_prok
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0044190 ! host cell mitochondrial envelope

[Term]
id: GO:0044192
name: host cell mitochondrial inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the host cell mitochondrial envelope. It is highly folded to form cristae." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044191 ! host cell mitochondrial membrane

[Term]
id: GO:0044193
name: host cell mitochondrial outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the host cell mitochondrial envelope." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044191 ! host cell mitochondrial membrane

[Term]
id: GO:0044194
name: cytolytic granule
namespace: cellular_component
def: "A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells." [GOC:jl, PMID:11052265, PMID:12766758]
is_a: GO:0005764 ! lysosome

[Term]
id: GO:0044195
name: nucleoplasmic reticulum
namespace: cellular_component
def: "Long, dynamic tubular channels, formed by invagination of the nuclear envelope, that extend deep into the nucleoplasm. The channels have an underlying lamina and are implicated in functioning in signaling and transport." [GOC:jl, PMID:17959832, PMID:9024685]
synonym: "nuclear channels" EXACT []
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005635 ! nuclear envelope

[Term]
id: GO:0044196
name: host cell nucleolus
namespace: cellular_component
def: "A small, dense body one or more of which are present in the nucleus of eukaryotic host cells." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044094 ! host cell nuclear part

[Term]
id: GO:0044197
name: Rel homology domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT." [http://en.wikipedia.org/wiki/Rel_homology_domain, InterPro:IPR011539]
synonym: "RHD binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0044198
name: zf-TRAF domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a TRAF-type zinc finger domain of a protein." [IPR:001293]
synonym: "TRAF-type zinc finger domain binding" EXACT []
synonym: "zinc finger TRAF-type domain binding" EXACT []
synonym: "zinc-finger-TRAF domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0044199
name: host cell nuclear envelope
namespace: cellular_component
def: "The double lipid bilayer enclosing the host nucleus and separating its contents from the rest of the host cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044094 ! host cell nuclear part
relationship: part_of GO:0033645 ! host cell endomembrane system

[Term]
id: GO:0044200
name: host cell nuclear membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround the host nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:jl]
subset: gosubset_prok
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0044199 ! host cell nuclear envelope

[Term]
id: GO:0044201
name: host cell nuclear inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, lipid bilayer of the host nuclear envelope." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044200 ! host cell nuclear membrane

[Term]
id: GO:0044202
name: host cell nuclear outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the host nuclear envelope; continuous with the endoplasmic reticulum of the host cell and sometimes studded with ribosomes." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044200 ! host cell nuclear membrane

[Term]
id: GO:0044203
name: host cell nuclear lamina
namespace: cellular_component
def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a host cell nucleus, composed of lamin filaments." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044094 ! host cell nuclear part
relationship: part_of GO:0044201 ! host cell nuclear inner membrane

[Term]
id: GO:0044204
name: host cell nuclear matrix
namespace: cellular_component
def: "The dense fibrillar network lying on the inner side of the host nuclear membrane." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044094 ! host cell nuclear part

[Term]
id: GO:0044205
name: 'de novo' UMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen." [GOC:ecd, GOC:jl]
synonym: "'de novo' UMP biosynthesis" EXACT []
is_a: GO:0006222 ! UMP biosynthetic process

[Term]
id: GO:0044206
name: UMP salvage
namespace: biological_process
def: "Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis." [GOC:ecd, PMID:15096496]
synonym: "UMP biosynthesis via nucleoside salvage pathway" EXACT []
synonym: "UMP biosynthetic process via nucleoside salvage pathway" EXACT []
is_a: GO:0006222 ! UMP biosynthetic process
is_a: GO:0010138 ! pyrimidine ribonucleotide salvage

[Term]
id: GO:0044207
name: translation initiation ternary complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:jl]
synonym: "Met-tRNA/eIF2.GTP ternary complex" NARROW []
synonym: "translation initiation (ternary) complex" EXACT []
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0044208
name: 'de novo' AMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP)." [GOC:ecd, PMID:10888601]
is_a: GO:0006167 ! AMP biosynthetic process

[Term]
id: GO:0044209
name: AMP salvage
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis." [GOC:ecd, GOC:jl, PMID:8917457, PMID:9864350]
synonym: "adenosine monophosphate salvage" EXACT []
synonym: "AMP biosynthetic process via salvage pathway" EXACT []
is_a: GO:0006167 ! AMP biosynthetic process
is_a: GO:0032261 ! purine nucleotide salvage

[Term]
id: GO:0044210
name: 'de novo' CTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components." [GOC:ecd, GOC:jl, PMID:11912132, PMID:18439916]
synonym: "'de novo' cytidine 5'-triphosphate biosynthetic process" EXACT []
is_a: GO:0006241 ! CTP biosynthetic process

[Term]
id: GO:0044211
name: CTP salvage
namespace: biological_process
def: "Any process which produces cytidine 5'-triphosphate (CTP) from derivatives of it, without de novo synthesis." [GOC:ecd, GOC:jl, PMID:10501935]
synonym: "CTP biosynthetic process via salvage pathway" EXACT []
synonym: "cytidine 5'-triphosphate salvage" EXACT []
is_a: GO:0006241 ! CTP biosynthetic process
is_a: GO:0010138 ! pyrimidine ribonucleotide salvage

[Term]
id: GO:0044212
name: DNA regulatory region binding
namespace: molecular_function
def: "Interacting selectively with a DNA sequence that controls the expression of a gene." [GOC:jl, SO:0005836]
is_a: GO:0003677 ! DNA binding

[Term]
id: GO:0044213
name: intronic regulatory region binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a kind of regulatory region that is part of an intron." [GOC:ecd]
is_a: GO:0044212 ! DNA regulatory region binding

[Term]
id: GO:0044214
name: fully spanning the plasma membrane
namespace: cellular_component
def: "Fully spanning both phospholipid bilayers of a plasma membrane." [GOC:ecd]
synonym: "transmembrane" RELATED [GOC:mah]
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0044215
name: other organism
namespace: cellular_component
def: "A secondary organism with which the first organism is interacting." [GOC:jl]
is_a: GO:0043245 ! extraorganismal space

[Term]
id: GO:0044216
name: other organism cell
namespace: cellular_component
def: "A cell of a secondary organism with which the first organism is interacting." [GOC:jl]
is_a: GO:0044217 ! other organism part

[Term]
id: GO:0044217
name: other organism part
namespace: cellular_component
def: "Any constituent part of a secondary organism with which the first organism is interacting." [GOC:jl]
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0044215 ! other organism

[Term]
id: GO:0044218
name: other organism cell membrane
namespace: cellular_component
def: "The cell membrane of a secondary organism with which the first organism is interacting." [GOC:jl]
synonym: "foreign membrane" RELATED []
is_a: GO:0044279 ! other organism membrane
relationship: part_of GO:0044216 ! other organism cell

[Term]
id: GO:0044219
name: host cell plasmodesma
namespace: cellular_component
def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one host cell to that of an adjacent host cell." [GOC:rph]
is_a: GO:0044156 ! host cell junction

[Term]
id: GO:0044220
name: host cell perinuclear region of cytoplasm
namespace: cellular_component
def: "The host cell cytoplasm situated near, or occurring around, the host nucleus." [GOC:rph]
is_a: GO:0033655 ! host cell cytoplasm part

[Term]
id: GO:0044221
name: host cell synapse
namespace: cellular_component
def: "The junction between a nerve fiber of one host neuron and another host neuron or muscle fiber or glial cell; the site of interneuronal communication." [GOC:rph]
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0018995 ! host

[Term]
id: GO:0044222
name: anammoxosome
namespace: cellular_component
def: "An intracytoplasmic membrane-bounded compartment in anaerobic ammonium oxidation (anammox) bacteria, is the site of anammox catabolism." [GOC:dh, PMID:17993524, PMID:19682260]
subset: gosubset_prok
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0044223
name: pirellulosome
namespace: cellular_component
def: "A cytoplasmic structure found in bacterial phyla Planctomycetes and Verrucomicrobia containing a condensed nucleoid and ribosomes and surrounded by an intracytoplasmic membrane. It is surrounded by ribosome-free cytoplasm, in a compartment called the paryphoplasm." [GOC:dh, PMID:19133117]
subset: gosubset_prok
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0044224
name: juxtaparanode region of axon
namespace: cellular_component
def: "A region of an axon near a node of Ranvier that is between the paranode and internode regions." [GOC:BHF, GOC:jl, PMID:10624965, PMID:14682359]
synonym: "juxtaparanodal region" EXACT []
synonym: "juxtaparanode" EXACT []
xref: NIF_Subcellular:sao758620702
is_a: GO:0033267 ! axon part
relationship: part_of GO:0044304 ! main axon

[Term]
id: GO:0044225
name: apical pole of neuron
namespace: cellular_component
def: "Portion of a neuron cell soma closest to the point where the apical dendrite emerges." [NIF_Subcellular:sao1186862860]
xref: NIF_Subcellular:sao1186862860
is_a: GO:0060187 ! cell pole
relationship: part_of GO:0043025 ! neuronal cell body

[Term]
id: GO:0044226
name: basal pole of neuron
namespace: cellular_component
def: "Portion of a neuron cell soma closest to the point where the basilar dendrite emerges." [NIF_Subcellular:sao1186862860]
xref: NIF_Subcellular:sao1186862860
is_a: GO:0060187 ! cell pole
relationship: part_of GO:0043025 ! neuronal cell body

[Term]
id: GO:0044227
name: methane-oxidizing organelle
namespace: cellular_component
def: "The cytoplasmic, a membrane-bound compartment found within Methanotrophic bacteria with enzymes and electron transfer proteins for methane catabolism. This structure is analogous to the thylakoid of Cyanobacteria and the anammoxosome of anaerobic ammonium oxidation organisms." [GOC:dh]
subset: gosubset_prok
synonym: "methane-oxidizing compartment" EXACT []
synonym: "methanotroph intracytoplasmic membrane-bound compartment" EXACT []
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0044228
name: host cell surface
namespace: cellular_component
def: "The external part of the host cell wall and/or host plasma membrane." [GOC:rph]
subset: gosubset_prok
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0044229
name: host cell periplasmic space
namespace: cellular_component
def: "The region between the inner (cytoplasmic) and outer host membrane (Gram-negative Bacteria) or inner host membrane and host cell wall (Fungi)." [GOC:rph]
subset: gosubset_prok
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0044230
name: host cell envelope
namespace: cellular_component
def: "An envelope that surrounds a bacterial host cell and includes the host cytoplasmic membrane and everything external, encompassing the host periplasmic space, host cell wall, and host outer membrane if present." [GOC:rph]
is_a: GO:0033643 ! host cell part

[Term]
id: GO:0044231
name: host cell presynaptic membrane
namespace: cellular_component
def: "A specialized area of membrane of the host axon terminal that faces the plasma membrane of the host neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many host synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:rph]
subset: gosubset_prok
is_a: GO:0033644 ! host cell membrane
relationship: part_of GO:0044221 ! host cell synapse

[Term]
id: GO:0044232
name: organelle membrane contact site
namespace: cellular_component
def: "A zone of apposition between the membranes of two organelles, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions." [GOC:jl, PMID:16806880]
synonym: "inter-organelle junction" EXACT []
synonym: "interorganelle junction" EXACT []
synonym: "MCS" EXACT []
is_a: GO:0044422 ! organelle part
relationship: part_of GO:0031090 ! organelle membrane

[Term]
id: GO:0044233
name: ER-mitochondrion membrane contact site
namespace: cellular_component
def: "A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange." [GOC:jl, PMID:19556461]
synonym: "endoplasmic-reticulum-mitochondrion membrane contact site" EXACT []
is_a: GO:0044232 ! organelle membrane contact site
relationship: part_of GO:0005789 ! endoplasmic reticulum membrane
relationship: part_of GO:0031966 ! mitochondrial membrane

[Term]
id: GO:0044234
name: cell wall organization in other organism
namespace: biological_process
def: "A process performed by an organism that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall of a second organism." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044235 ! cellular component organization in other organism
is_a: GO:0071555 ! cell wall organization

[Term]
id: GO:0044235
name: cellular component organization in other organism
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component in a second organism." [GOC:jl]
is_a: GO:0016043 ! cellular component organization
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0044236
name: multicellular organismal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required." [GOC:go_curators]
synonym: "multicellular organismal metabolism" EXACT []
is_a: GO:0008152 ! metabolic process
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0044237
name: cellular metabolic process
namespace: biological_process
def: "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "cellular metabolism" EXACT []
synonym: "intermediary metabolism" RELATED [GOC:mah]
is_a: GO:0008152 ! metabolic process
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0044238
name: primary metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org]
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
synonym: "primary metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0044239
name: salivary polysaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides by salivary amylase. Salivary amylase is released by salivary glands, usually in the mouth." [GOC:jl, http://www.emc.maricopa.edu/]
synonym: "salivary polysaccharide breakdown" EXACT []
synonym: "salivary polysaccharide catabolism" EXACT []
synonym: "salivary polysaccharide degradation" EXACT []
is_a: GO:0044244 ! multicellular organismal polysaccharide catabolic process

[Term]
id: GO:0044240
name: multicellular organismal lipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipids, occurring at the tissue, organ, or organismal level of a multicellular organism." [GOC:jl]
synonym: "organismal lipid breakdown" EXACT []
synonym: "organismal lipid catabolism" EXACT []
synonym: "organismal lipid degradation" EXACT []
is_a: GO:0016042 ! lipid catabolic process
is_a: GO:0044243 ! multicellular organismal catabolic process
relationship: part_of GO:0044241 ! lipid digestion

[Term]
id: GO:0044241
name: lipid digestion
namespace: biological_process
def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism." [GOC:go_curators]
xref: Reactome:192456 "Digestion of dietary lipid"
xref: Reactome:449034 "Digestion of dietary lipid"
xref: Reactome:470147 "Digestion of dietary lipid"
xref: Reactome:487844 "Digestion of dietary lipid"
xref: Reactome:507807 "Digestion of dietary lipid"
xref: Reactome:517724 "Digestion of dietary lipid"
xref: Reactome:542471 "Digestion of dietary lipid"
is_a: GO:0007586 ! digestion

[Term]
id: GO:0044242
name: cellular lipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells." [GOC:jl]
subset: gosubset_prok
synonym: "cellular lipid breakdown" EXACT []
synonym: "cellular lipid catabolism" EXACT []
synonym: "cellular lipid degradation" EXACT []
is_a: GO:0016042 ! lipid catabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0044243
name: multicellular organismal catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of substances in multicellular organisms that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required." [GOC:go_curators]
synonym: "organismal breakdown" EXACT []
synonym: "organismal catabolism" EXACT []
synonym: "organismal degradation" EXACT []
is_a: GO:0044236 ! multicellular organismal metabolic process

[Term]
id: GO:0044244
name: multicellular organismal polysaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, occurring at the tissue, organ, or organismal level of a multicellular organism." [GOC:jl]
synonym: "organismal polysaccharide breakdown" EXACT []
synonym: "organismal polysaccharide catabolism" EXACT []
synonym: "organismal polysaccharide degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0044263 ! multicellular organismal polysaccharide metabolic process
is_a: GO:0044276 ! multicellular organismal carbohydrate catabolic process
relationship: part_of GO:0044245 ! polysaccharide digestion

[Term]
id: GO:0044245
name: polysaccharide digestion
namespace: biological_process
def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism." [GOC:go_curators]
xref: Reactome:189085 "Digestion of dietary carbohydrate"
xref: Reactome:449033 "Digestion of dietary carbohydrate"
xref: Reactome:470146 "Digestion of dietary carbohydrate"
xref: Reactome:487843 "Digestion of dietary carbohydrate"
xref: Reactome:507806 "Digestion of dietary carbohydrate"
xref: Reactome:517723 "Digestion of dietary carbohydrate"
xref: Reactome:526560 "Digestion of dietary carbohydrate"
xref: Reactome:531512 "Digestion of dietary carbohydrate"
xref: Reactome:536903 "Digestion of dietary carbohydrate"
xref: Reactome:542470 "Digestion of dietary carbohydrate"
xref: Reactome:547803 "Digestion of dietary carbohydrate"
xref: Reactome:552539 "Digestion of dietary carbohydrate"
xref: Reactome:558081 "Digestion of dietary carbohydrate"
xref: Reactome:568623 "Digestion of dietary carbohydrate"
xref: Reactome:581827 "Digestion of dietary carbohydrate"
xref: Reactome:585918 "Digestion of dietary carbohydrate"
xref: Reactome:592737 "Digestion of dietary carbohydrate"
xref: Reactome:597427 "Digestion of dietary carbohydrate"
xref: Reactome:599743 "Digestion of dietary carbohydrate"
is_a: GO:0007586 ! digestion

[Term]
id: GO:0044246
name: regulation of multicellular organismal metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:go_curators, GOC:tb]
synonym: "regulation of organismal metabolic process" EXACT [GOC:tb]
synonym: "regulation of organismal metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0044236 ! multicellular organismal metabolic process

[Term]
id: GO:0044247
name: cellular polysaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells." [GOC:jl]
subset: gosubset_prok
synonym: "cellular polysaccharide breakdown" EXACT []
synonym: "cellular polysaccharide catabolism" EXACT []
synonym: "cellular polysaccharide degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process

[Term]
id: GO:0044248
name: cellular catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl]
subset: gosubset_prok
synonym: "cellular breakdown" EXACT []
synonym: "cellular catabolism" EXACT []
synonym: "cellular degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0044249
name: cellular biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]
subset: gosubset_prok
synonym: "cellular anabolism" EXACT []
synonym: "cellular biosynthesis" EXACT []
synonym: "cellular formation" EXACT []
synonym: "cellular synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0044250
name: negative regulation of metabolic activity during hibernation
namespace: biological_process
def: "The slowing of metabolic processes to very low levels in order to conserve energy during hibernation." [GOC:jl, Wikipedia:Hibernation]
synonym: "down regulation of metabolic activity during hibernation" EXACT []
synonym: "down-regulation of metabolic activity during hibernation" EXACT []
synonym: "downregulation of metabolic activity during hibernation" EXACT []
synonym: "inhibition of metabolic activity during hibernation" NARROW []
is_a: GO:0044252 ! negative regulation of multicellular organismal metabolic process
relationship: part_of GO:0042750 ! hibernation

[Term]
id: GO:0044251
name: protein catabolic process by pepsin
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein by pepsin in the stomach. Pepsin is generated from its precursor pepsinogen, which is activated by hydrolchloric acid (gastric acid)." [GOC:jl, http://www.emc.maricopa.edu/]
synonym: "protein breakdown by pepsin" EXACT []
synonym: "protein degradation by pepsin" EXACT []
is_a: GO:0044254 ! multicellular organismal protein catabolic process

[Term]
id: GO:0044252
name: negative regulation of multicellular organismal metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:jl]
synonym: "down regulation of organismal metabolic process" EXACT []
synonym: "down-regulation of organismal metabolic process" EXACT []
synonym: "downregulation of organismal metabolic process" EXACT []
synonym: "inhibition of organismal metabolic process" NARROW []
synonym: "negative regulation of organismal metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0044246 ! regulation of multicellular organismal metabolic process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0044236 ! multicellular organismal metabolic process

[Term]
id: GO:0044253
name: positive regulation of multicellular organismal metabolic process
namespace: biological_process
def: "Any process that activates or increases frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:jl]
synonym: "activation of organismal metabolic process" NARROW []
synonym: "positive regulation of organismal metabolism" EXACT []
synonym: "stimulation of organismal metabolic process" NARROW []
synonym: "up regulation of organismal metabolic process" EXACT []
synonym: "up-regulation of organismal metabolic process" EXACT []
synonym: "upregulation of organismal metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0044246 ! regulation of multicellular organismal metabolic process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0044236 ! multicellular organismal metabolic process

[Term]
id: GO:0044254
name: multicellular organismal protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein in a multicellular organism, occurring at the tissue, organ, or organismal level." [GOC:jl]
synonym: "organismal protein breakdown" EXACT []
synonym: "organismal protein catabolism" EXACT []
synonym: "organismal protein degradation" EXACT []
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0044243 ! multicellular organismal catabolic process
is_a: GO:0044266 ! multicellular organismal macromolecule catabolic process
is_a: GO:0044268 ! multicellular organismal protein metabolic process
relationship: part_of GO:0044256 ! protein digestion

[Term]
id: GO:0044255
name: cellular lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "cellular lipid metabolism" EXACT []
is_a: GO:0006629 ! lipid metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0044256
name: protein digestion
namespace: biological_process
def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism." [GOC:go_curators]
is_a: GO:0007586 ! digestion

[Term]
id: GO:0044257
name: cellular protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:jl]
subset: goslim_yeast
subset: gosubset_prok
synonym: "cellular protein breakdown" EXACT []
synonym: "cellular protein catabolism" EXACT []
synonym: "cellular protein degradation" EXACT []
xref: Reactome:174731 "Degradation of newly synthesized ApoB-48"
xref: Reactome:436257 "Degradation of newly synthesized ApoB-48"
xref: Reactome:458667 "Degradation of newly synthesized ApoB-48"
xref: Reactome:478002 "Degradation of newly synthesized ApoB-48"
xref: Reactome:497657 "Degradation of newly synthesized ApoB-48"
xref: Reactome:512808 "Degradation of newly synthesized ApoB-48"
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0044265 ! cellular macromolecule catabolic process
is_a: GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0044258
name: intestinal lipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas." [GOC:jl, http://www.emc.maricopa.edu/]
synonym: "intestinal lipid breakdown" EXACT []
synonym: "intestinal lipid catabolism" EXACT []
synonym: "intestinal lipid degradation" EXACT []
is_a: GO:0044240 ! multicellular organismal lipid catabolic process

[Term]
id: GO:0044259
name: multicellular organismal macromolecule metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl]
synonym: "organismal macromolecule metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044236 ! multicellular organismal metabolic process

[Term]
id: GO:0044260
name: cellular macromolecule metabolic process
namespace: biological_process
alt_id: GO:0034960
def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells." [ChEBI:33694, GOC:mah]
subset: gosubset_prok
synonym: "cellular biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "cellular macromolecule metabolism" EXACT []
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0044261
name: multicellular organismal carbohydrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, in multicellular organisms, occurring at the tissue, organ, or organismal level." [GOC:jl]
synonym: "organismal carbohydrate metabolism" EXACT []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0044259 ! multicellular organismal macromolecule metabolic process

[Term]
id: GO:0044262
name: cellular carbohydrate metabolic process
namespace: biological_process
alt_id: GO:0006092
def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]
subset: goslim_yeast
subset: gosubset_prok
synonym: "cellular carbohydrate metabolism" EXACT []
synonym: "main pathways of carbohydrate metabolic process" NARROW []
synonym: "main pathways of carbohydrate metabolism" NARROW []
is_a: GO:0005975 ! carbohydrate metabolic process
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0044263
name: multicellular organismal polysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:jl]
synonym: "organismal glycan metabolic process" EXACT []
synonym: "organismal glycan metabolism" EXACT []
synonym: "organismal polysaccharide metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0044261 ! multicellular organismal carbohydrate metabolic process

[Term]
id: GO:0044264
name: cellular polysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells." [GOC:jl]
subset: gosubset_prok
synonym: "cellular glycan metabolic process" EXACT []
synonym: "cellular glycan metabolism" EXACT []
synonym: "cellular polysaccharide metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process
is_a: GO:0044260 ! cellular macromolecule metabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0044265
name: cellular macromolecule catabolic process
namespace: biological_process
alt_id: GO:0034962
def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells." [ChEBI:33694, GOC:jl]
subset: gosubset_prok
synonym: "cellular biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09]
synonym: "cellular macromolecule breakdown" EXACT []
synonym: "cellular macromolecule catabolism" EXACT []
synonym: "cellular macromolecule degradation" EXACT []
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0044266
name: multicellular organismal macromolecule catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl]
synonym: "organismal macromolecule breakdown" EXACT []
synonym: "organismal macromolecule catabolism" EXACT []
synonym: "organismal macromolecule degradation" EXACT []
is_a: GO:0009057 ! macromolecule catabolic process

[Term]
id: GO:0044267
name: cellular protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification." [GOC:jl]
subset: gosubset_prok
synonym: "cellular protein metabolism" EXACT []
xref: Reactome:392499 "Metabolism of proteins"
xref: Reactome:448469 "Metabolism of proteins"
xref: Reactome:469599 "Metabolism of proteins"
xref: Reactome:487318 "Metabolism of proteins"
xref: Reactome:507269 "Metabolism of proteins"
xref: Reactome:517286 "Metabolism of proteins"
xref: Reactome:526164 "Metabolism of proteins"
xref: Reactome:531061 "Metabolism of proteins"
xref: Reactome:536443 "Metabolism of proteins"
xref: Reactome:542138 "Metabolism of proteins"
xref: Reactome:547505 "Metabolism of proteins"
xref: Reactome:552209 "Metabolism of proteins"
xref: Reactome:557676 "Metabolism of proteins"
xref: Reactome:568296 "Metabolism of proteins"
xref: Reactome:581498 "Metabolism of proteins"
xref: Reactome:585742 "Metabolism of proteins"
xref: Reactome:592395 "Metabolism of proteins"
xref: Reactome:595285 "Metabolism of proteins"
xref: Reactome:597396 "Metabolism of proteins"
xref: Reactome:598178 "Metabolism of proteins"
xref: Reactome:599777 "Metabolism of proteins"
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0044268
name: multicellular organismal protein metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl]
synonym: "organismal protein metabolism" EXACT []
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0044259 ! multicellular organismal macromolecule metabolic process

[Term]
id: GO:0044269
name: glycerol ether catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:jl]
subset: gosubset_prok
synonym: "glycerol ether breakdown" EXACT []
synonym: "glycerol ether catabolism" EXACT []
synonym: "glycerol ether degradation" EXACT []
is_a: GO:0006662 ! glycerol ether metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0044270
name: cellular nitrogen compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "nitrogen compound breakdown" EXACT []
synonym: "nitrogen compound catabolism" EXACT []
synonym: "nitrogen compound degradation" EXACT []
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0044271
name: cellular nitrogen compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "nitrogen compound anabolism" EXACT []
synonym: "nitrogen compound biosynthesis" EXACT []
synonym: "nitrogen compound formation" EXACT []
synonym: "nitrogen compound synthesis" EXACT []
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0044272
name: sulfur compound biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl]
subset: gosubset_prok
synonym: "sulfur biosynthesis" NARROW []
synonym: "sulfur biosynthetic process" NARROW []
synonym: "sulfur compound anabolism" EXACT []
synonym: "sulfur compound biosynthesis" EXACT []
synonym: "sulfur compound formation" EXACT []
synonym: "sulfur compound synthesis" EXACT []
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0044273
name: sulfur compound catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl]
subset: gosubset_prok
synonym: "sulfur catabolic process" NARROW []
synonym: "sulfur catabolism" NARROW []
synonym: "sulfur compound breakdown" EXACT []
synonym: "sulfur compound catabolism" EXACT []
synonym: "sulfur compound degradation" EXACT []
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0044274
name: multicellular organismal biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of substances in multicellular organisms, occurring at the tissue, organ, or organismal level." [GOC:jl]
synonym: "organismal anabolism" EXACT []
synonym: "organismal biosynthesis" EXACT []
synonym: "organismal formation" EXACT []
synonym: "organismal synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process

[Term]
id: GO:0044275
name: cellular carbohydrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]
subset: gosubset_prok
synonym: "cellular carbohydrate breakdown" EXACT []
synonym: "cellular carbohydrate catabolism" EXACT []
synonym: "cellular carbohydrate degradation" EXACT []
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process
is_a: GO:0044265 ! cellular macromolecule catabolic process

[Term]
id: GO:0044276
name: multicellular organismal carbohydrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl]
synonym: "organismal carbohydrate breakdown" EXACT []
synonym: "organismal carbohydrate catabolism" EXACT []
synonym: "organismal carbohydrate degradation" EXACT []
is_a: GO:0016052 ! carbohydrate catabolic process
is_a: GO:0044243 ! multicellular organismal catabolic process
is_a: GO:0044261 ! multicellular organismal carbohydrate metabolic process
is_a: GO:0044266 ! multicellular organismal macromolecule catabolic process

[Term]
id: GO:0044277
name: cell wall disassembly
namespace: biological_process
def: "A process that results in the breakdown of the cell wall." [GOC:jl]
subset: gosubset_prok
is_a: GO:0071555 ! cell wall organization

[Term]
id: GO:0044278
name: cell wall disassembly in other organism
namespace: biological_process
def: "A process carried out by an organism that results in the breakdown of the cell wall of a second organism." [GOC:jl]
is_a: GO:0044277 ! cell wall disassembly

[Term]
id: GO:0044279
name: other organism membrane
namespace: cellular_component
def: "A membrane of a secondary organism with which the first organism is interacting." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044217 ! other organism part

[Term]
id: GO:0044280
name: subplasmalemmal coating
namespace: cellular_component
def: "Electron dense material observed coating the cytoplasmic face of the plasma membrane in certain regions of a neuron, e.g., the axon initial segment; the nodal membrane at the Node of Ranvier." [NIF_Subcellular:sao1938587839]
xref: NIF_Subcellular:sao1938587839
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0031232 ! extrinsic to external side of plasma membrane

[Term]
id: GO:0044281
name: small molecule metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass." [GOC:curators, GOC:vw]
synonym: "small molecule metabolism" EXACT []
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0044282
name: small molecule catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass." [GOC:curators, GOC:vw]
synonym: "small molecule catabolism" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0044283
name: small molecule biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass." [GOC:curators, GOC:vw]
synonym: "small molecule biosynthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0044284
name: crista junction
namespace: cellular_component
def: "Tubular structures of relatively uniform size that connect mitochondrial cristae to the inner mitchondrial membrane." [NIF_Subcellular:sao1825845900]
xref: NIF_Subcellular:sao1825845900
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0044285
name: bridge contact site
namespace: cellular_component
def: "Site of contact between the inner and outer mitochondrial membrane found in neuronal mitochondria; may play a role in maintaining the structural integrity of the inner and outer boundary membranes." [NIF_Subcellular:sao1858501007]
xref: NIF_Subcellular:sao1858501007
is_a: GO:0044455 ! mitochondrial membrane part

[Term]
id: GO:0044286
name: peg and socket contact
namespace: cellular_component
def: "Contact between an endothelial cell and a pericyte consisting of membrane invaginations extending from either cell type, which contain tight-, gap-, and adherence junctions." [NIF_Subcellular:sao1943947957]
xref: NIF_Subcellular:sao1943947957
is_a: GO:0044291 ! cell-cell contact zone

[Term]
id: GO:0044288
name: puncta adhaerentia
namespace: cellular_component
def: "A small version of the zonula adherens type junction, characterized by a symmetrical adherent point between two cells." [NIF_Subcellular:sao257629430]
xref: NIF_Subcellular:sao257629430
is_a: GO:0005915 ! zonula adherens

[Term]
id: GO:0044289
name: contact site
namespace: cellular_component
def: "Sites of close apposition of the inner and outer mitochondrial membrane." [NIF_Subcellular:sao447856407]
xref: NIF_Subcellular:sao447856407
is_a: GO:0044455 ! mitochondrial membrane part

[Term]
id: GO:0044290
name: mitochondrial intracristal space
namespace: cellular_component
def: "The space bounded by the mitochondrial cristae membranes, continuous with the intermembrane space." [NIF_Subcellular:sao508958414]
xref: NIF_Subcellular:sao508958414
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0044291
name: cell-cell contact zone
namespace: cellular_component
def: "Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle." [NIF_Subcellular:sao1299635018]
synonym: "cell cell contact zone" EXACT []
xref: NIF_Subcellular:sao1299635018
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0044292
name: dendrite terminus
namespace: cellular_component
def: "A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole." [GOC:jl, NIF_Subcellular:sao28175134]
synonym: "dendrite terminal" EXACT []
synonym: "dendrite terminal specialization" RELATED []
synonym: "terminal specialization of a dendrite" EXACT []
xref: NIF_Subcellular:sao28175134
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:0044293
name: dendriole
namespace: cellular_component
def: "Small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell (UBC)." [GOC:jl, NIF_Subcellular:sao28175134, PMID:8300904]
xref: NIF_Subcellular:sao28175134
is_a: GO:0044292 ! dendrite terminus

[Term]
id: GO:0044294
name: dendritic growth cone
namespace: cellular_component
def: "The migrating motile tip of a growing nerve cell dendrite." [GOC:jl]
synonym: "dendrite growth cone" EXACT []
xref: NIF_Subcellular:sao1594955670
is_a: GO:0030426 ! growth cone
is_a: GO:0044292 ! dendrite terminus

[Term]
id: GO:0044295
name: axonal growth cone
namespace: cellular_component
def: "The migrating motile tip of a growing nerve cell axon." [GOC:jl]
synonym: "axon growth cone" EXACT []
xref: NIF_Subcellular:sao1594955670
is_a: GO:0030426 ! growth cone
is_a: GO:0033267 ! axon part

[Term]
id: GO:0044296
name: dendritic tuft
namespace: cellular_component
def: "The terminal specialization found in some types of dendrites which consists of numerous small terminal branches, giving the dendrite a tufted appearance." [NIF_Subcellular:sao1340260079]
synonym: "dendrite tuft" EXACT []
xref: NIF_Subcellular:sao1340260079
is_a: GO:0044292 ! dendrite terminus

[Term]
id: GO:0044297
name: cell body
namespace: cellular_component
def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]
comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections.
subset: goslim_pir
synonym: "cell soma" EXACT []
is_a: GO:0044464 ! cell part

[Term]
id: GO:0044298
name: cell body membrane
namespace: cellular_component
def: "The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections." [GOC:ecd]
synonym: "cell soma membrane" EXACT []
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0044297 ! cell body

[Term]
id: GO:0044299
name: C-fiber
namespace: cellular_component
def: "The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated." [NIF_Subcellular:nlx_subcell_20090210]
synonym: "C-fibre" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090210
is_a: GO:0030424 ! axon

[Term]
id: GO:0044300
name: cerebellar mossy fiber
namespace: cellular_component
def: "An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons as \"mossy\" appearance in Golgi stained preparations." [NIF_Subcellular:nlx_subcell_20090209]
synonym: "cerebellar mossy fibre" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090209
is_a: GO:0030424 ! axon

[Term]
id: GO:0044301
name: climbing fiber
namespace: cellular_component
def: "The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to \"climb\" along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber." [NIF_Subcellular:nlx_subcell_20090203]
synonym: "climbing fibre" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090203
is_a: GO:0030424 ! axon

[Term]
id: GO:0044302
name: dentate gyrus mossy fiber
namespace: cellular_component
def: "Distinctive, unmyelinated axons produced by granule cells." [NIF_Subcellular:nlx_subcell_20090601, PMID:17765709]
synonym: "dentate gyrus mossy fibre" EXACT []
synonym: "granule cell axon" EXACT []
xref: NIF_Subcellular:nlx_subcell_20090601
is_a: GO:0030424 ! axon

[Term]
id: GO:0044303
name: axon collateral
namespace: cellular_component
def: "Any of the smaller branches of an axon that emanate from the main axon cylinder." [NIF_Subcellular:sao1470140754]
xref: NIF_Subcellular:sao1470140754
is_a: GO:0033267 ! axon part

[Term]
id: GO:0044304
name: main axon
namespace: cellular_component
def: "The main axonal trunk, as opposed to the collaterals." [NIF_Subcellular:sao1596975044]
synonym: "axon trunk" EXACT []
xref: NIF_Subcellular:sao1596975044
is_a: GO:0033267 ! axon part

[Term]
id: GO:0044305
name: calyx of Held
namespace: cellular_component
def: "The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system." [NIF_Subcellular:sao1684283879, PMID:11823805]
xref: NIF_Subcellular:sao1684283879
is_a: GO:0043679 ! axon terminus

[Term]
id: GO:0044306
name: neuron projection terminus
namespace: cellular_component
def: "The specialized, terminal region of a neuron projection such as an axon or a dendrite." [GOC:jl]
synonym: "neuron projection terminal" EXACT []
synonym: "neuron terminal specialization" EXACT []
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0043005 ! neuron projection

[Term]
id: GO:0044307
name: dendritic branch
namespace: cellular_component
def: "A dendrite arising from another dendrite." [NIF_Subcellular:sao884265541]
synonym: "dendrite branch" EXACT []
xref: NIF_Subcellular:sao884265541
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0030425 ! dendrite

[Term]
id: GO:0044308
name: axonal spine
namespace: cellular_component
def: "A spine that originates from the axon, usually from the initial segment." [NIF_Subcellular:sao18239917]
synonym: "axon spine" EXACT []
xref: NIF_Subcellular:sao18239917
is_a: GO:0033267 ! axon part
is_a: GO:0044309 ! neuron spine

[Term]
id: GO:0044309
name: neuron spine
namespace: cellular_component
def: "A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck." [ISBN:0198504888, NIF_Subcellular:sao1145756102]
xref: NIF_Subcellular:sao1145756102
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:0044310
name: osmiophilic body
namespace: cellular_component
def: "A membrane-bound vesicle found predominantly in Plasmodium female gametocytes, that becomes progressively more abundant as the gametocyte reaches full maturity. These vesicles lie beneath the subpellicular membrane of the gametocyte, and the release of their contents into the parasitophorous vacuole has been postulated to aid in the escape of gametocytes from the erythrocyte after ingestion by the mosquito." [GOC:jl, PMID:18086189]
is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0044311
name: exoneme
namespace: cellular_component
def: "A dense granule-like organelle of the apical complex of merozoites, released into the parasitophorous vacuole, mediating protease-dependent rupture and parasite exit from the infected erythrocyte." [GOC:jl, PMID:18083092, PMID:18083098]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0044312
name: crystalloid
namespace: cellular_component
def: "A transient, cytoplasmic organelle found in Plasmodium species that resembles a cytoplasmic inclusion body and whose function is poorly understood. Crystalloids form in ookinetes and disappear after ookinete-to-oocyst transformation." [GOC:jl, PMID:19932717]
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0044399
name: multi-species biofilm formation
namespace: biological_process
def: "A process whereby microorganisms of different species attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc]
subset: gosubset_prok
is_a: GO:0042710 ! biofilm formation
is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0044400
name: multi-species biofilm formation on inanimate substrate
namespace: biological_process
def: "A process whereby microorganisms of different species attach to and grow on an inanimate surface such as a rock or pipe and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044399 ! multi-species biofilm formation

[Term]
id: GO:0044401
name: multi-species biofilm formation in or on host organism
namespace: biological_process
def: "A process whereby microorganisms of different species attach to and grow in or on a surface in a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044399 ! multi-species biofilm formation
is_a: GO:0044406 ! adhesion to host

[Term]
id: GO:0044402
name: competition with another organism
namespace: biological_process
def: "Any process by which an organism within a multispecies research community gains an advantage in growth or survival over another organism of a different species in that research community." [GOC:cc]
subset: gosubset_prok
synonym: "interspecies competition" BROAD []
is_a: GO:0044419 ! interspecies interaction between organisms

[Term]
id: GO:0044403
name: symbiosis, encompassing mutualism through parasitism
namespace: biological_process
alt_id: GO:0043298
alt_id: GO:0044404
def: "An interaction between two organisms living together in more or less intimate association. The term host is usually used for the larger (macro) of the two members of a symbiosis. The smaller (micro) member is called the symbiont organism. Microscopic symbionts are often referred to as endosymbionts. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs." [GOC:cc, http://www.free-definition.com]
comment: Note that this term encompasses all symbiotic relationships between species along a continuum from mutualism through to parasitism, as outlined in the definition.
subset: goslim_generic
subset: gosubset_prok
synonym: "host-pathogen interaction" RELATED []
synonym: "symbiosis" EXACT []
synonym: "symbiotic interaction" EXACT []
synonym: "symbiotic interaction between host and organism" RELATED []
synonym: "symbiotic interaction between organisms" EXACT []
synonym: "symbiotic interaction between species" EXACT []
synonym: "symbiotic interaction with other non-host organism" RELATED []
is_a: GO:0044419 ! interspecies interaction between organisms

[Term]
id: GO:0044405
name: recognition of host
namespace: biological_process
def: "The set of specific processes that allow an organism to detect the presence of its host via physical or chemical signals. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "detection of host" EXACT []
is_a: GO:0051824 ! recognition of other organism during symbiotic interaction
is_a: GO:0075136 ! response to host

[Term]
id: GO:0044406
name: adhesion to host
namespace: biological_process
def: "The attachment of an organism to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "host adhesion" EXACT []
is_a: GO:0051701 ! interaction with host
is_a: GO:0051825 ! adhesion to other organism during symbiotic interaction

[Term]
id: GO:0044407
name: single-species biofilm formation in or on host organism
namespace: biological_process
def: "A process whereby microorganisms of the same species attach to and grow in or on a surface in a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044010 ! single-species biofilm formation
is_a: GO:0044406 ! adhesion to host

[Term]
id: GO:0044408
name: growth or development of symbiont on or near host
namespace: biological_process
def: "OBSOLETE. Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism." [GOC:cc]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of symbiont on or near host ; GO:0044133' and 'development of symbiont on or near host ; GO:0044132'.
subset: gosubset_prok
synonym: "growth or development of organism on or near host surface" EXACT []
is_obsolete: true
replaced_by: GO:0044132
replaced_by: GO:0044133

[Term]
id: GO:0044409
name: entry into host
namespace: biological_process
def: "Penetration by an organism into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "host invasion" EXACT []
synonym: "invasion into host" EXACT []
synonym: "invasion of host" EXACT []
synonym: "invasive growth" RELATED []
is_a: GO:0051828 ! entry into other organism during symbiotic interaction
is_a: GO:0052126 ! movement in host environment

[Term]
id: GO:0044410
name: entry into host through natural portals
namespace: biological_process
def: "Penetration by an organism into its host organism via naturally occurring openings in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044409 ! entry into host
is_a: GO:0051829 ! entry into other organism through natural portals during symbiotic interaction

[Term]
id: GO:0044411
name: entry into host through host barriers
namespace: biological_process
def: "Penetration by an organism into its host organism via active breaching of the physical barriers of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044409 ! entry into host
is_a: GO:0051830 ! entry into other organism through barriers of other organism during symbiotic interaction

[Term]
id: GO:0044412
name: growth or development of symbiont in host
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host ; GO:0044114' and 'growth of symbiont in host ; GO:0044117'.
subset: gosubset_prok
synonym: "growth or development of organism within host" EXACT []
synonym: "growth or development of symbiont within host" EXACT []
synonym: "invasive growth" BROAD []
is_obsolete: true
replaced_by: GO:0044114
replaced_by: GO:0044117

[Term]
id: GO:0044413
name: avoidance of host defenses
namespace: biological_process
def: "Any process, either constitutive or induced, by which an organism evades, suppresses or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "avoidance of host defences" EXACT []
is_a: GO:0051832 ! avoidance of defenses of other organism during symbiotic interaction
is_a: GO:0052200 ! response to host defenses

[Term]
id: GO:0044414
name: suppression of host defenses
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "negative regulation of host defenses" EXACT []
is_a: GO:0044413 ! avoidance of host defenses
is_a: GO:0051833 ! suppression of defenses of other organism during symbiotic interaction

[Term]
id: GO:0044415
name: evasion or tolerance of host defenses
namespace: biological_process
def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044413 ! avoidance of host defenses
is_a: GO:0051834 ! evasion or tolerance of defenses of other organism during symbiotic interaction

[Term]
id: GO:0044416
name: induction by symbiont of host defense response
namespace: biological_process
def: "The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "activation of host defense response" EXACT []
is_a: GO:0052251 ! induction by organism of defense response of other organism during symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response

[Term]
id: GO:0044417
name: translocation of molecules into host
namespace: biological_process
def: "The directed movement of a molecule(s) produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "transport of molecules into host" EXACT []
is_a: GO:0051701 ! interaction with host
is_a: GO:0051836 ! translocation of molecules into other organism during symbiotic interaction

[Term]
id: GO:0044418
name: translocation of DNA into host
namespace: biological_process
def: "The directed movement of DNA from an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]
synonym: "transport of DNA into host" EXACT []
is_a: GO:0044417 ! translocation of molecules into host
is_a: GO:0051837 ! translocation of DNA into other organism during symbiotic interaction

[Term]
id: GO:0044419
name: interspecies interaction between organisms
namespace: biological_process
def: "Any process by which an organism has an effect on an organism of a different species." [GOC:cc]
subset: goslim_candida
subset: goslim_pir
subset: gosubset_prok
synonym: "interaction with another species" EXACT []
synonym: "interspecies interaction" EXACT []
synonym: "interspecies interaction with other organisms" EXACT []
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0044420
name: extracellular matrix part
namespace: cellular_component
def: "Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants)." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0031012 ! extracellular matrix

[Term]
id: GO:0044421
name: extracellular region part
namespace: cellular_component
def: "Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite." [GOC:jl]
subset: gosubset_prok
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005576 ! extracellular region

[Term]
id: GO:0044422
name: organelle part
namespace: cellular_component
def: "Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane." [GOC:jl]
subset: gosubset_prok
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0043226 ! organelle

[Term]
id: GO:0044423
name: virion part
namespace: cellular_component
def: "Any constituent part of a virion, a complete fully infectious extracellular virus particle." [GOC:jl]
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0019012 ! virion

[Term]
id: GO:0044424
name: intracellular part
namespace: cellular_component
def: "Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044464 ! cell part
relationship: part_of GO:0005622 ! intracellular

[Term]
id: GO:0044425
name: membrane part
namespace: cellular_component
def: "Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044464 ! cell part
relationship: part_of GO:0016020 ! membrane

[Term]
id: GO:0044426
name: cell wall part
namespace: cellular_component
def: "Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0005618 ! cell wall

[Term]
id: GO:0044427
name: chromosomal part
namespace: cellular_component
def: "Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [GOC:jl]
subset: gosubset_prok
synonym: "chromosomal component" EXACT []
synonym: "chromosome component" EXACT []
synonym: "chromosome part" EXACT []
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005694 ! chromosome

[Term]
id: GO:0044428
name: nuclear part
namespace: cellular_component
def: "Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated." [GOC:jl]
synonym: "nucleus component" EXACT []
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005634 ! nucleus

[Term]
id: GO:0044429
name: mitochondrial part
namespace: cellular_component
def: "Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:jl]
synonym: "mitochondrion component" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005739 ! mitochondrion

[Term]
id: GO:0044430
name: cytoskeletal part
namespace: cellular_component
def: "Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice." [GOC:jl]
synonym: "cytoskeleton component" EXACT []
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005856 ! cytoskeleton

[Term]
id: GO:0044431
name: Golgi apparatus part
namespace: cellular_component
def: "Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl]
synonym: "Golgi component" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005794 ! Golgi apparatus

[Term]
id: GO:0044432
name: endoplasmic reticulum part
namespace: cellular_component
def: "Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae." [GOC:jl]
synonym: "ER component" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005783 ! endoplasmic reticulum
relationship: part_of GO:0071212 ! subsynaptic reticulum

[Term]
id: GO:0044433
name: cytoplasmic vesicle part
namespace: cellular_component
def: "Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0031410 ! cytoplasmic vesicle

[Term]
id: GO:0044434
name: chloroplast part
namespace: cellular_component
def: "Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [GOC:jl]
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0009507 ! chloroplast

[Term]
id: GO:0044435
name: plastid part
namespace: cellular_component
def: "Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0009536 ! plastid

[Term]
id: GO:0044436
name: thylakoid part
namespace: cellular_component
def: "Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0009579 ! thylakoid

[Term]
id: GO:0044437
name: vacuolar part
namespace: cellular_component
def: "Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material." [GOC:jl]
subset: gosubset_prok
synonym: "vacuole component" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005773 ! vacuole

[Term]
id: GO:0044438
name: microbody part
namespace: cellular_component
def: "Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [GOC:jl]
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0042579 ! microbody

[Term]
id: GO:0044439
name: peroxisomal part
namespace: cellular_component
def: "Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [GOC:jl]
synonym: "peroxisome component" EXACT []
is_a: GO:0044438 ! microbody part
relationship: part_of GO:0005777 ! peroxisome

[Term]
id: GO:0044440
name: endosomal part
namespace: cellular_component
def: "Any constituent part of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [GOC:jl]
synonym: "endosome component" EXACT []
is_a: GO:0044444 ! cytoplasmic part
is_a: GO:0044446 ! intracellular organelle part
relationship: part_of GO:0005768 ! endosome

[Term]
id: GO:0044441
name: cilium part
namespace: cellular_component
def: "Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:jl]
is_a: GO:0044446 ! intracellular organelle part
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0005929 ! cilium

[Term]
id: GO:0044442
name: microtubule-based flagellum part
namespace: cellular_component
def: "Any constituent part of a microtubule-based flagellum, a long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. The flagellum is based on a 9+2 arrangement of microtubules. Examples of this component are found in Mus musculus." [GOC:jl, GOC:mtg_sensu]
synonym: "flagellar part" BROAD []
is_a: GO:0044446 ! intracellular organelle part
is_a: GO:0044460 ! flagellum part
relationship: part_of GO:0009434 ! microtubule-based flagellum

[Term]
id: GO:0044443
name: pilus part
namespace: cellular_component
def: "Any constituent part of a pilus, a proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter." [GOC:pamgo_curators]
subset: gosubset_prok
synonym: "fimbrial part" EXACT []
synonym: "fimbrium component" EXACT []
synonym: "pilus component" EXACT []
is_a: GO:0044446 ! intracellular organelle part
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0009289 ! pilus

[Term]
id: GO:0044444
name: cytoplasmic part
namespace: cellular_component
def: "Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:jl]
subset: gosubset_prok
synonym: "cytoplasm component" EXACT []
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0005737 ! cytoplasm

[Term]
id: GO:0044445
name: cytosolic part
namespace: cellular_component
def: "Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:jl]
subset: gosubset_prok
synonym: "cytosol component" EXACT []
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0005829 ! cytosol

[Term]
id: GO:0044446
name: intracellular organelle part
namespace: cellular_component
def: "A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044422 ! organelle part
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0043229 ! intracellular organelle

[Term]
id: GO:0044447
name: axoneme part
namespace: cellular_component
def: "Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements." [GOC:jl]
is_a: GO:0044422 ! organelle part
is_a: GO:0044424 ! intracellular part
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0005930 ! axoneme

[Term]
id: GO:0044448
name: cell cortex part
namespace: cellular_component
def: "Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:jl]
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0005938 ! cell cortex

[Term]
id: GO:0044449
name: contractile fiber part
namespace: cellular_component
def: "Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:jl]
synonym: "contractile fibre component" EXACT []
synonym: "muscle fiber component" BROAD []
synonym: "muscle fibre component" BROAD []
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0043292 ! contractile fiber

[Term]
id: GO:0044450
name: microtubule organizing center part
namespace: cellular_component
def: "Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow." [GOC:jl]
synonym: "microtubule organizing centre component" EXACT []
synonym: "MTOC component" EXACT []
is_a: GO:0044430 ! cytoskeletal part
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0005815 ! microtubule organizing center

[Term]
id: GO:0044451
name: nucleoplasm part
namespace: cellular_component
def: "Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus." [GOC:jl]
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005654 ! nucleoplasm

[Term]
id: GO:0044452
name: nucleolar part
namespace: cellular_component
def: "Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis." [GOC:jl]
synonym: "nucleolus component" EXACT []
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005730 ! nucleolus

[Term]
id: GO:0044453
name: nuclear membrane part
namespace: cellular_component
def: "Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells." [GOC:jl]
is_a: GO:0044425 ! membrane part
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0031965 ! nuclear membrane

[Term]
id: GO:0044454
name: nuclear chromosome part
namespace: cellular_component
def: "Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell." [GOC:jl]
is_a: GO:0044427 ! chromosomal part
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0000228 ! nuclear chromosome

[Term]
id: GO:0044455
name: mitochondrial membrane part
namespace: cellular_component
def: "Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:jl]
is_a: GO:0044425 ! membrane part
is_a: GO:0044429 ! mitochondrial part
relationship: part_of GO:0031966 ! mitochondrial membrane

[Term]
id: GO:0044456
name: synapse part
namespace: cellular_component
def: "Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:jl]
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0045202 ! synapse

[Term]
id: GO:0044457
name: cell septum part
namespace: cellular_component
def: "Any constituent part of a cell septum, a structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:jl]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0030428 ! cell septum

[Term]
id: GO:0044459
name: plasma membrane part
namespace: cellular_component
def: "Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0005886 ! plasma membrane

[Term]
id: GO:0044460
name: flagellum part
namespace: cellular_component
def: "Any constituent part of a flagellum, a long whiplike or feathery structure borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [GOC:jl]
subset: gosubset_prok
synonym: "flagellum component" EXACT []
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0019861 ! flagellum

[Term]
id: GO:0044461
name: bacterial-type flagellum part
namespace: cellular_component
def: "Any constituent part of flagellum, a 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by the transmembrane proton potential. Examples of this component are found in bacterial species." [GOC:jl, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "flagellin-based flagellum part" EXACT []
is_a: GO:0044460 ! flagellum part
relationship: part_of GO:0009288 ! bacterial-type flagellum

[Term]
id: GO:0044462
name: external encapsulating structure part
namespace: cellular_component
def: "Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044464 ! cell part
relationship: part_of GO:0030312 ! external encapsulating structure

[Term]
id: GO:0044463
name: cell projection part
namespace: cellular_component
def: "Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl]
subset: gosubset_prok
is_a: GO:0044464 ! cell part
relationship: part_of GO:0042995 ! cell projection

[Term]
id: GO:0044464
name: cell part
namespace: cellular_component
def: "Any constituent part of a cell, the basic structural and functional unit of all organisms." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "protoplast" RELATED [GOC:mah]
is_a: GO:0005575 ! cellular_component
relationship: part_of GO:0005623 ! cell

[Term]
id: GO:0045002
name: double-strand break repair via single-strand annealing
namespace: biological_process
def: "Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats." [PMID:11606529]
subset: gosubset_prok
is_a: GO:0000726 ! non-recombinational repair
is_a: GO:0006302 ! double-strand break repair

[Term]
id: GO:0045003
name: double-strand break repair via synthesis-dependent strand annealing
namespace: biological_process
def: "SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855]
subset: gosubset_prok
synonym: "mitotic gene conversion" RELATED []
synonym: "SDSA" BROAD []
xref: Reactome:83667 "Resolution of D-loop structures through synthesis-dependent strand-annealing"
is_a: GO:0000724 ! double-strand break repair via homologous recombination

[Term]
id: GO:0045004
name: DNA replication proofreading
namespace: biological_process
def: "Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006281 ! DNA repair
is_a: GO:0045005 ! maintenance of fidelity during DNA-dependent DNA replication

[Term]
id: GO:0045005
name: maintenance of fidelity during DNA-dependent DNA replication
namespace: biological_process
def: "A DNA metabolic process that prevents or corrects errors during DNA replication. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair." [GOC:mah, GOC:vw]
subset: gosubset_prok
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0045006
name: DNA deamination
namespace: biological_process
def: "The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006304 ! DNA modification

[Term]
id: GO:0045007
name: depurination
namespace: biological_process
def: "The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar." [GOC:ai]
subset: gosubset_prok
xref: Reactome:110330 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:110331 "Cleavage of the damaged purine"
xref: Reactome:448966 "Cleavage of the damaged purine"
xref: Reactome:448967 "Depurination"
xref: Reactome:449142 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:470086 "Cleavage of the damaged purine"
xref: Reactome:470087 "Depurination"
xref: Reactome:470256 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:487775 "Cleavage of the damaged purine"
xref: Reactome:487776 "Depurination"
xref: Reactome:487935 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:507740 "Cleavage of the damaged purine"
xref: Reactome:507741 "Depurination"
xref: Reactome:507906 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:517675 "Cleavage of the damaged purine"
xref: Reactome:517676 "Depurination"
xref: Reactome:517795 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:531310 "Cleavage of the damaged purine"
xref: Reactome:531311 "Depurination"
xref: Reactome:531425 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:536693 "Cleavage of the damaged purine"
xref: Reactome:536694 "Depurination"
xref: Reactome:536795 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:542426 "Cleavage of the damaged purine"
xref: Reactome:542427 "Depurination"
xref: Reactome:542553 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:547775 "Cleavage of the damaged purine"
xref: Reactome:547776 "Depurination"
xref: Reactome:547908 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:552335 "Cleavage of the damaged purine"
xref: Reactome:552336 "Depurination"
xref: Reactome:552456 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:557941 "Cleavage of the damaged purine"
xref: Reactome:557942 "Depurination"
xref: Reactome:558065 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:568576 "Cleavage of the damaged purine"
xref: Reactome:568577 "Depurination"
xref: Reactome:568711 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:581782 "Cleavage of the damaged purine"
xref: Reactome:581783 "Depurination"
xref: Reactome:581914 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:585891 "Cleavage of the damaged purine"
xref: Reactome:585892 "Depurination"
xref: Reactome:585984 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:592697 "Cleavage of the damaged purine"
xref: Reactome:592698 "Depurination"
xref: Reactome:592808 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:595447 "Cleavage of the damaged purine"
xref: Reactome:595448 "Depurination"
xref: Reactome:595535 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:599727 "Cleavage of the damaged purine"
xref: Reactome:599728 "Depurination"
xref: Reactome:599772 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:600629 "Cleavage of the damaged purine"
xref: Reactome:600630 "Depurination"
xref: Reactome:600691 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:602530 "Cleavage of the damaged purine"
xref: Reactome:602531 "Depurination"
xref: Reactome:602599 "Recognition and association of DNA glycosylase with site containing an affected purine"
xref: Reactome:73927 "Depurination"
xref: Wikipedia:Depurination
is_a: GO:0006285 ! base-excision repair, AP site formation
is_a: GO:0006304 ! DNA modification
is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process

[Term]
id: GO:0045008
name: depyrimidination
namespace: biological_process
def: "The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar." [GOC:ai]
subset: gosubset_prok
xref: Reactome:110328 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:110329 "Cleavage of the damaged pyrimidine"
xref: Reactome:448970 "Cleavage of the damaged pyrimidine"
xref: Reactome:448971 "Depyrimidination"
xref: Reactome:449141 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:470090 "Cleavage of the damaged pyrimidine"
xref: Reactome:470091 "Depyrimidination"
xref: Reactome:470255 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:487779 "Cleavage of the damaged pyrimidine"
xref: Reactome:487780 "Depyrimidination"
xref: Reactome:487934 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:507744 "Cleavage of the damaged pyrimidine"
xref: Reactome:507745 "Depyrimidination"
xref: Reactome:507905 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:517672 "Cleavage of the damaged pyrimidine"
xref: Reactome:517673 "Depyrimidination"
xref: Reactome:517794 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:526507 "Cleavage of the damaged pyrimidine"
xref: Reactome:526508 "Depyrimidination"
xref: Reactome:526625 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:531314 "Cleavage of the damaged pyrimidine"
xref: Reactome:531315 "Depyrimidination"
xref: Reactome:531424 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:536697 "Cleavage of the damaged pyrimidine"
xref: Reactome:536698 "Depyrimidination"
xref: Reactome:536794 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:542433 "Cleavage of the damaged pyrimidine"
xref: Reactome:542434 "Depyrimidination"
xref: Reactome:542552 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:547782 "Cleavage of the damaged pyrimidine"
xref: Reactome:547783 "Depyrimidination"
xref: Reactome:547878 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:552338 "Cleavage of the damaged pyrimidine"
xref: Reactome:552339 "Depyrimidination"
xref: Reactome:552455 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:557944 "Cleavage of the damaged pyrimidine"
xref: Reactome:557945 "Depyrimidination"
xref: Reactome:558064 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:568579 "Cleavage of the damaged pyrimidine"
xref: Reactome:568580 "Depyrimidination"
xref: Reactome:568710 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:581785 "Cleavage of the damaged pyrimidine"
xref: Reactome:581786 "Depyrimidination"
xref: Reactome:581913 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:585894 "Cleavage of the damaged pyrimidine"
xref: Reactome:585895 "Depyrimidination"
xref: Reactome:585951 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:592700 "Cleavage of the damaged pyrimidine"
xref: Reactome:592701 "Depyrimidination"
xref: Reactome:592807 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:595450 "Cleavage of the damaged pyrimidine"
xref: Reactome:595451 "Depyrimidination"
xref: Reactome:595534 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:597382 "Cleavage of the damaged pyrimidine"
xref: Reactome:597383 "Depyrimidination"
xref: Reactome:597419 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:598164 "Cleavage of the damaged pyrimidine"
xref: Reactome:598165 "Depyrimidination"
xref: Reactome:598188 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:599730 "Cleavage of the damaged pyrimidine"
xref: Reactome:599731 "Depyrimidination"
xref: Reactome:599760 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:600632 "Cleavage of the damaged pyrimidine"
xref: Reactome:600633 "Depyrimidination"
xref: Reactome:600661 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:602533 "Cleavage of the damaged pyrimidine"
xref: Reactome:602534 "Depyrimidination"
xref: Reactome:602570 "Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
xref: Reactome:73928 "Depyrimidination"
is_a: GO:0006285 ! base-excision repair, AP site formation
is_a: GO:0006304 ! DNA modification
is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process

[Term]
id: GO:0045009
name: chitosome
namespace: cellular_component
def: "An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:8970154]
is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0045010
name: actin nucleation
namespace: biological_process
def: "The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194]
synonym: "actin filament nucleation" EXACT []
is_a: GO:0007015 ! actin filament organization

[Term]
id: GO:0045012
name: MHC class II receptor activity
namespace: molecular_function
def: "OBSOLETE. A major histocompatibility complex class II receptor. These display processed antigens from virally-infected or transformed cells. Class-II-positive cells ('antigen-presenting cells') can take up antigens from outside by endocytosis, degrade them into small peptides, and re-export the peptides (now bound to MHC class II protein) to the cell surface. These peptide-MHC class II complexes can then be recognized by specific CD4+ lymphocytes." [ISBN:081533642X, ISBN:0879694971]
comment: This term was made obsolete because it was defined ambiguously, and has therefore been used incorrectly in annotations. To update annotations of gene products that act as receptors for MHC class II protein complexes, use the molecular function term 'MHC class II receptor activity ; GO:0032395'; to update annotations of gene products which are components of MHC class II protein complexes, use the cellular component term 'MHC class II protein complex ; GO:0042613'.
synonym: "class II major histocompatibility complex antigen" RELATED []
synonym: "major histocompatibility complex class II receptor" EXACT []
is_obsolete: true
consider: GO:0032395
consider: GO:0042613

[Term]
id: GO:0045013
name: negative regulation of transcription by carbon catabolites
namespace: biological_process
def: "Any process involving carbon catabolites that stops, prevents or reduces the rate of transcription. Carbon catabolite repression is a mechanism of genetic regulation in bacteria in which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11018147]
subset: gosubset_prok
synonym: "carbon catabolite repression" EXACT []
synonym: "down regulation of transcription by carbon catabolites" EXACT []
synonym: "down-regulation of transcription by carbon catabolites" EXACT []
synonym: "downregulation of transcription by carbon catabolites" EXACT []
synonym: "inhibition of transcription by carbon catabolites" NARROW []
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent
is_a: GO:0045990 ! regulation of transcription by carbon catabolites

[Term]
id: GO:0045014
name: negative regulation of transcription by glucose
namespace: biological_process
def: "Any process involving glucose that stops, prevents or reduces the rate of transcription. The presence of glucose in the growth medium inhibits the synthesis of certain enzymes in bacteria growing on the medium. For example, transcription of some catabolic operons is under negative control by specific repressors and glucose is an anti-inducer of xylose utilization and glycerol kinase." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11018147]
subset: gosubset_prok
synonym: "down regulation of transcription by glucose" EXACT []
synonym: "down-regulation of transcription by glucose" EXACT []
synonym: "downregulation of transcription by glucose" EXACT []
synonym: "glucose effect" EXACT []
synonym: "glucose repression" EXACT []
synonym: "inhibition of transcription by glucose" NARROW []
is_a: GO:0045013 ! negative regulation of transcription by carbon catabolites
is_a: GO:0046015 ! regulation of transcription by glucose

[Term]
id: GO:0045015
name: HDEL sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [PMID:1327759]
synonym: "HDEL receptor activity" NARROW []
is_a: GO:0046923 ! ER retention sequence binding

[Term]
id: GO:0045016
name: mitochondrial magnesium ion transport
namespace: biological_process
def: "The transport of magnesium ions (Mg2+) into, out of or within a mitochondrion. Transport across the mitochondrial membranes is mediated by a mitochondrial inner membrane protein." [GOC:ai, PMID:11254124]
is_a: GO:0006839 ! mitochondrial transport
is_a: GO:0015693 ! magnesium ion transport

[Term]
id: GO:0045017
name: glycerolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]
subset: gosubset_prok
synonym: "glycerolipid anabolism" EXACT []
synonym: "glycerolipid biosynthesis" EXACT []
synonym: "glycerolipid formation" EXACT []
synonym: "glycerolipid synthesis" EXACT []
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0046486 ! glycerolipid metabolic process

[Term]
id: GO:0045018
name: retrograde transport, vacuole to Golgi
namespace: biological_process
def: "The directed movement of substances from the vacuole to the trans-Golgi network; this occurs in yeast via the prevacuolar/endosomal compartment." [PMID:9700156]
synonym: "retrograde transport from the vacuole" EXACT []
is_a: GO:0007034 ! vacuolar transport

[Term]
id: GO:0045019
name: negative regulation of nitric oxide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators]
synonym: "down regulation of nitric oxide biosynthetic process" EXACT []
synonym: "down-regulation of nitric oxide biosynthetic process" EXACT []
synonym: "downregulation of nitric oxide biosynthetic process" EXACT []
synonym: "inhibition of nitric oxide biosynthetic process" NARROW []
synonym: "negative regulation of nitric oxide anabolism" EXACT []
synonym: "negative regulation of nitric oxide biosynthesis" EXACT []
synonym: "negative regulation of nitric oxide formation" EXACT []
synonym: "negative regulation of nitric oxide synthesis" EXACT []
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0045428 ! regulation of nitric oxide biosynthetic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
relationship: negatively_regulates GO:0006809 ! nitric oxide biosynthetic process

[Term]
id: GO:0045020
name: error-prone DNA repair
namespace: biological_process
def: "OBSOLETE. DNA repair pathways that tend to increase the endogenous mutation rate." [GOC:jl, PMID:11459974]
comment: This term was made obsolete because 'error-prone' does not correspond to a repair mechanism, and the term has been superseded by more specific terms.
synonym: "mutagenic DNA repair" EXACT []
is_obsolete: true
consider: GO:0042276

[Term]
id: GO:0045021
name: error-free DNA repair
namespace: biological_process
def: "OBSOLETE. DNA repair pathways that do not increase the mutation rate above spontaneous background levels, e.g. excision and recombination pathways." [GOC:jl, PMID:11459974]
comment: This term was made obsolete because 'error-free' does not correspond to a repair mechanism, and the term has been superseded by more specific terms.
subset: gosubset_prok
is_obsolete: true
consider: GO:0042275
consider: GO:0070987

[Term]
id: GO:0045022
name: early endosome to late endosome transport
namespace: biological_process
def: "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194]
is_a: GO:0016197 ! endosome transport

[Term]
id: GO:0045023
name: G0 to G1 transition
namespace: biological_process
def: "The transition from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression." [ISBN:0716731363]
is_a: GO:0000320 ! re-entry into mitotic cell cycle

[Term]
id: GO:0045024
name: peptidyl-glutamyl peptide hydrolyzing enzyme activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids." [PMID:11735414]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0070011

[Term]
id: GO:0045025
name: mitochondrial degradosome
namespace: cellular_component
def: "The mitochondrial degradosome (mtEXO) is a three-protein complex which has a 3' to 5' exoribonuclease activity and participates in intron-independent turnover and processing of mitochondrial transcripts." [PMID:10397341, PMID:9829834]
is_a: GO:0044429 ! mitochondrial part

[Term]
id: GO:0045026
name: plasma membrane fusion
namespace: biological_process
alt_id: GO:0006947
def: "The joining of two or more lipid bilayer membranes that surround a cell." [GOC:elh, GOC:mtg_muscle]
synonym: "cell fusion" BROAD []
synonym: "cell-cell fusion" BROAD []
is_a: GO:0006944 ! cellular membrane fusion

[Term]
id: GO:0045027
name: DNA end binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the ends of DNA that are exposed by the creation of double-strand breaks (DSBs)." [GOC:jl]
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0045028
name: purinergic nucleotide receptor activity, G-protein coupled
namespace: molecular_function
def: "Combining with a purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:mah, PMID:9755289]
synonym: "G protein coupled purinergic nucleotide receptor activity" EXACT []
synonym: "G-protein coupled purinergic nucleotide receptor activity" EXACT []
synonym: "G-protein-coupled purinergic nucleotide receptor activity" EXACT []
synonym: "P2Y" RELATED []
synonym: "purinergic nucleotide receptor activity, G protein coupled" EXACT []
is_a: GO:0001608 ! nucleotide receptor activity, G-protein coupled
is_a: GO:0001614 ! purinergic nucleotide receptor activity

[Term]
id: GO:0045029
name: UDP-activated nucleotide receptor activity
namespace: molecular_function
def: "Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP." [GOC:mah]
is_a: GO:0015065 ! uridine nucleotide receptor activity

[Term]
id: GO:0045030
name: UTP-activated nucleotide receptor activity
namespace: molecular_function
def: "Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP." [GOC:mah]
is_a: GO:0015065 ! uridine nucleotide receptor activity

[Term]
id: GO:0045031
name: ATP-activated nucleotide receptor activity
namespace: molecular_function
def: "Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ATP." [GOC:mah]
is_a: GO:0001609 ! adenosine receptor activity, G-protein coupled

[Term]
id: GO:0045032
name: ADP-activated nucleotide receptor activity
namespace: molecular_function
def: "Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ADP." [GOC:mah]
is_a: GO:0001609 ! adenosine receptor activity, G-protein coupled

[Term]
id: GO:0045033
name: peroxisome inheritance
namespace: biological_process
def: "The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p." [PMID:11733545]
is_a: GO:0007031 ! peroxisome organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0045034
name: neuroblast division
namespace: biological_process
alt_id: GO:0043345
alt_id: GO:0043346
def: "OBSOLETE. The asymmetrical division of a neuroblast, the neural precursor in the central nervous system, giving rise to another neuroblast and a ganglion mother cell." [PMID:11163136, PMID:11250167]
comment: This term was made obsolete because the definition was incorrect. Not all neuroblasts divide asymmetrically. Neuroblasts give rise to neurons after division.
synonym: "neuroblast cell division" EXACT []
synonym: "neuroblast division (sensu Nematoda and Protostomia)" EXACT []
synonym: "neuroblast division (sensu Vertebrata)" EXACT []
is_obsolete: true

[Term]
id: GO:0045035
name: sensory organ precursor cell division
namespace: biological_process
def: "The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597]
synonym: "sense organ precursor cell division" EXACT [GOC:dph]
is_a: GO:0008356 ! asymmetric cell division
relationship: part_of GO:0007423 ! sensory organ development

[Term]
id: GO:0045036
name: protein targeting to chloroplast
namespace: biological_process
def: "The process of directing proteins towards the chloroplast, usually using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved." [ISBN:0716731363]
synonym: "protein-chloroplast targeting" EXACT []
is_a: GO:0006605 ! protein targeting

[Term]
id: GO:0045037
name: protein import into chloroplast stroma
namespace: biological_process
def: "The import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import." [ISBN:0716731363]
synonym: "chloroplast stroma protein import" EXACT []
synonym: "protein transport into chloroplast stroma" EXACT []
is_a: GO:0017038 ! protein import
is_a: GO:0045036 ! protein targeting to chloroplast

[Term]
id: GO:0045038
name: protein import into chloroplast thylakoid membrane
namespace: biological_process
def: "The import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma." [ISBN:0716731363]
synonym: "chloroplast thylakoid membrane protein import" EXACT []
synonym: "protein transport into chloroplast thylakoid membrane" EXACT []
is_a: GO:0006612 ! protein targeting to membrane
is_a: GO:0017038 ! protein import
is_a: GO:0045036 ! protein targeting to chloroplast

[Term]
id: GO:0045039
name: protein import into mitochondrial inner membrane
namespace: biological_process
def: "The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known." [ISBN:0716731363]
synonym: "mitochondrial inner membrane protein import" EXACT []
synonym: "protein transport into mitochondrial inner membrane" EXACT []
is_a: GO:0006612 ! protein targeting to membrane
is_a: GO:0006626 ! protein targeting to mitochondrion
is_a: GO:0007007 ! inner mitochondrial membrane organization

[Term]
id: GO:0045040
name: protein import into mitochondrial outer membrane
namespace: biological_process
def: "The import of proteins into the outer membrane of the mitochondrion. Outer membrane proteins have a short matrix-targeting sequence followed by a long stretch of hydrophobic amino acids at the N-terminus. The hydrophobic sequence functions as a stop-transfer sequence that both prevents transfer of the protein into the matrix and anchors it as an integral protein in the outer membrane." [ISBN:0716731363]
synonym: "mitochondrial outer membrane protein import" EXACT []
synonym: "protein transport into mitochondrial outer membrane" EXACT []
is_a: GO:0006612 ! protein targeting to membrane
is_a: GO:0006626 ! protein targeting to mitochondrion
is_a: GO:0007008 ! outer mitochondrial membrane organization

[Term]
id: GO:0045041
name: protein import into mitochondrial intermembrane space
namespace: biological_process
alt_id: GO:0045043
alt_id: GO:0045044
def: "The import of proteins into the space between the inner and outer mitochondrial membranes." [ISBN:0716731363]
synonym: "mitochondrial intermembrane space protein import" EXACT []
synonym: "protein import into mitochondrial IMS" EXACT []
synonym: "protein import into mitochondrial intermembrane space, direct" NARROW [GOC:mcc]
synonym: "protein import into mitochondrial intermembrane space, nonconservative" NARROW [GOC:mcc]
synonym: "protein transport into mitochondrial IMS" EXACT []
synonym: "protein transport into mitochondrial intermembrane space" EXACT []
is_a: GO:0006626 ! protein targeting to mitochondrion
is_a: GO:0065002 ! intracellular protein transmembrane transport

[Term]
id: GO:0045042
name: protein import into mitochondrial intermembrane space, conservative
namespace: biological_process
def: "OBSOLETE. The conservative import of proteins into the mitochondrial intermembrane space. The entire protein enters the matrix, and then the second targeting sequence directs the protein, presumably bound to a matrix protein, across the inner membrane to the intermembrane space." [ISBN:0716731363]
comment: This term was made obsolete because there is no 'conservative' process of protein import into the mitochondrial intermembrane space that is distinct from the more general parent; furthermore, 'conservative' is used in the literature to describe a pathway of import into the inner membrane rather than into the intermembrane space.
synonym: "conservative mitochondrial IMS protein import" EXACT []
synonym: "conservative mitochondrial intermembrane space protein import" EXACT []
synonym: "conservative protein transport into mitochondrial IMS" EXACT []
synonym: "conservative protein transport into mitochondrial intermembrane space" EXACT []
synonym: "protein import into mitochondrial IMS, conservative" EXACT []
synonym: "protein transport into mitochondrial IMS, conservative" EXACT []
synonym: "protein transport into mitochondrial intermembrane space, conservative" EXACT []
is_obsolete: true
consider: GO:0045039
consider: GO:0045041

[Term]
id: GO:0045045
name: secretory pathway
namespace: biological_process
def: "OBSOLETE. The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane." [ISBN:0716731363]
comment: This term was made obsolete because it artificially groups a number of other terms, leading to path problems, its definition is unclear (and lacks genus-differentia features), and it has probably been used incorrectly in annotations.
is_obsolete: true
replaced_by: GO:0032940

[Term]
id: GO:0045046
name: protein import into peroxisome membrane
namespace: biological_process
def: "The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import." [ISBN:0716731363, PMID:11687502]
synonym: "peroxisome membrane protein import" EXACT []
synonym: "protein transport into peroxisome membrane" EXACT []
is_a: GO:0006612 ! protein targeting to membrane
is_a: GO:0006625 ! protein targeting to peroxisome
is_a: GO:0017038 ! protein import

[Term]
id: GO:0045047
name: protein targeting to ER
namespace: biological_process
def: "The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363]
synonym: "protein targeting to endoplasmic reticulum" EXACT []
synonym: "protein-endoplasmic reticulum targeting" EXACT []
synonym: "protein-ER targeting" EXACT []
is_a: GO:0006605 ! protein targeting
relationship: part_of GO:0070972 ! protein localization in endoplasmic reticulum

[Term]
id: GO:0045048
name: protein insertion into ER membrane
namespace: biological_process
def: "The process by which a protein is incorporated into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane." [ISBN:0716731363]
synonym: "integral ER membrane protein localization" EXACT []
synonym: "integral ER membrane protein positioning" EXACT []
synonym: "localization of protein in ER membrane" EXACT []
synonym: "positioning of protein in ER membrane" EXACT []
synonym: "protein insertion into endoplasmic reticulum membrane" EXACT []
synonym: "protein-endoplasmic reticulum insertion" EXACT []
synonym: "protein-ER insertion" EXACT []
is_a: GO:0051205 ! protein insertion into membrane
relationship: part_of GO:0007029 ! endoplasmic reticulum organization

[Term]
id: GO:0045049
name: protein insertion into ER membrane by N-terminal cleaved signal sequence
namespace: biological_process
def: "The insertion of integral proteins into the endoplasmic reticulum membrane. N-terminal cleaved signal sequences direct polypeptides to the ER." [ISBN:0716731363]
synonym: "N-terminal cleaved signal sequence mediated protein insertion into ER membrane" EXACT []
synonym: "protein insertion into endoplasmic reticulum membrane by N-terminal cleaved signal sequence" EXACT []
synonym: "protein insertion into ER membrane, N-terminal cleaved signal sequence mediated" EXACT []
synonym: "protein-endoplasmic reticulum insertion by N-terminal cleaved signal sequence" EXACT []
synonym: "protein-ER insertion by N-terminal cleaved signal sequence" EXACT []
is_a: GO:0045048 ! protein insertion into ER membrane

[Term]
id: GO:0045050
name: protein insertion into ER membrane by stop-transfer membrane-anchor sequence
namespace: biological_process
def: "The insertion of integral proteins into the endoplasmic reticulum membrane. Stop-transfer membrane-anchor sequences become an ER membrane spanning helix." [ISBN:0716731363]
synonym: "protein insertion into endoplasmic reticulum membrane by stop-transfer membrane-anchor sequence" EXACT []
synonym: "protein insertion into ER membrane, stop-transfer membrane-anchor sequence mediated" EXACT []
synonym: "protein-endoplasmic reticulum insertion by stop-transfer membrane-anchor sequence" EXACT []
synonym: "protein-ER insertion by stop-transfer membrane-anchor sequence" EXACT []
synonym: "stop-transfer membrane-anchor sequence mediated protein insertion into ER membrane" EXACT []
is_a: GO:0045048 ! protein insertion into ER membrane

[Term]
id: GO:0045051
name: protein insertion into ER membrane by internal uncleaved signal-anchor sequence
namespace: biological_process
def: "The insertion of integral proteins into the endoplasmic reticulum membrane. Signal anchor sequences function as both ER signal sequences and membrane anchor sequences." [ISBN:0716731363]
synonym: "internal uncleaved signal-anchor sequence mediated protein insertion into ER membrane" EXACT []
synonym: "protein insertion into endoplasmic reticulum membrane by internal uncleaved signal-anchor sequence" EXACT []
synonym: "protein insertion into ER membrane, internal uncleaved signal-anchor sequence mediated" EXACT []
synonym: "protein-endoplasmic reticulum insertion by internal uncleaved signal-anchor sequence" EXACT []
synonym: "protein-ER insertion by internal uncleaved signal-anchor sequence" EXACT []
is_a: GO:0045048 ! protein insertion into ER membrane

[Term]
id: GO:0045052
name: protein insertion into ER membrane by GPI attachment sequence
namespace: biological_process
def: "The insertion of integral proteins into the endoplasmic reticulum membrane. Proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule." [ISBN:0716731363]
synonym: "GPI attachment sequence mediated protein insertion into ER membrane" EXACT []
synonym: "protein insertion into endoplasmic reticulum membrane by GPI attachment sequence" EXACT []
synonym: "protein insertion into ER membrane, GPI attachment sequence mediated" EXACT []
synonym: "protein-endoplasmic reticulum insertion by GPI attachment sequence" EXACT []
synonym: "protein-ER insertion by GPI attachment sequence" EXACT []
is_a: GO:0045048 ! protein insertion into ER membrane

[Term]
id: GO:0045053
name: protein retention in Golgi apparatus
namespace: biological_process
def: "The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]
synonym: "maintenance of protein location in Golgi apparatus" RELATED []
synonym: "protein-Golgi retention" EXACT []
synonym: "retention of protein in Golgi" EXACT []
is_a: GO:0032507 ! maintenance of protein location in cell
relationship: part_of GO:0034067 ! protein localization in Golgi apparatus

[Term]
id: GO:0045054
name: constitutive secretory pathway
namespace: biological_process
def: "A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space." [GOC:mah, ISBN:0716731363]
is_a: GO:0006887 ! exocytosis

[Term]
id: GO:0045055
name: regulated secretory pathway
namespace: biological_process
def: "A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand." [GOC:mah, ISBN:0716731363]
is_a: GO:0006887 ! exocytosis

[Term]
id: GO:0045056
name: transcytosis
namespace: biological_process
def: "The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side." [ISBN:0716731363]
xref: Wikipedia:Transcytosis
is_a: GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0045057
name: cisternal progression
namespace: biological_process
def: "The process by which a new cis-Golgi stack physically moves from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna." [ISBN:0716731363]
synonym: "cisternal maturation" EXACT []
is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport

[Term]
id: GO:0045058
name: T cell selection
namespace: biological_process
def: "The process by which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722]
synonym: "T lymphocyte selection" EXACT []
synonym: "T-cell selection" EXACT []
synonym: "T-lymphocyte selection" EXACT []
xref: Wikipedia:Thymocyte
is_a: GO:0002376 ! immune system process
relationship: part_of GO:0030217 ! T cell differentiation

[Term]
id: GO:0045059
name: positive thymic T cell selection
namespace: biological_process
def: "The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722]
synonym: "positive thymic T lymphocyte selection" EXACT []
synonym: "positive thymic T-cell selection" EXACT []
synonym: "positive thymic T-lymphocyte selection" EXACT []
is_a: GO:0043368 ! positive T cell selection
is_a: GO:0045061 ! thymic T cell selection

[Term]
id: GO:0045060
name: negative thymic T cell selection
namespace: biological_process
def: "The process of elimination of immature T cells in the thymus which react strongly with self-antigens." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722]
synonym: "negative thymic T lymphocyte selection" EXACT []
synonym: "negative thymic T-cell selection" EXACT []
synonym: "negative thymic T-lymphocyte selection" EXACT []
is_a: GO:0043383 ! negative T cell selection
is_a: GO:0045061 ! thymic T cell selection

[Term]
id: GO:0045061
name: thymic T cell selection
namespace: biological_process
def: "The process of T cell selection that occurs in the thymus." [ISBN:0781735149 "Fundamental Immunology", PMID:12414722]
synonym: "thymic T lymphocyte selection" EXACT []
synonym: "thymic T-cell selection" EXACT []
synonym: "thymic T-lymphocyte selection" EXACT []
is_a: GO:0045058 ! T cell selection
relationship: part_of GO:0033077 ! T cell differentiation in the thymus

[Term]
id: GO:0045062
name: extrathymic T cell selection
namespace: biological_process
def: "The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus." [ISBN:0781735149 "Fundamental Immunology", PMID:7880383]
synonym: "extrathymic T lymphocyte selection" EXACT []
synonym: "extrathymic T-cell selection" EXACT []
synonym: "extrathymic T-lymphocyte selection" EXACT []
is_a: GO:0045058 ! T cell selection
relationship: part_of GO:0033078 ! extrathymic T cell differentiation

[Term]
id: GO:0045063
name: T-helper 1 cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized T cell acquires the specialized features of a Th1 cell." [GOC:ebc]
is_a: GO:0042093 ! T-helper cell differentiation
relationship: part_of GO:0042088 ! T-helper 1 type immune response

[Term]
id: GO:0045064
name: T-helper 2 cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized T cell acquires specialized features of a Th2 cell." [GOC:ebc]
is_a: GO:0042093 ! T-helper cell differentiation
relationship: part_of GO:0042092 ! T-helper 2 type immune response

[Term]
id: GO:0045065
name: cytotoxic T cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell." [GOC:ai]
synonym: "cytotoxic T lymphocyte selection" EXACT []
synonym: "cytotoxic T-cell selection" EXACT []
synonym: "cytotoxic T-lymphocyte selection" EXACT []
is_a: GO:0030217 ! T cell differentiation

[Term]
id: GO:0045066
name: regulatory T cell differentiation
namespace: biological_process
def: "The process by which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "regulatory T lymphocyte differentiation" EXACT []
synonym: "regulatory T-cell differentiation" EXACT []
synonym: "regulatory T-lymphocyte differentiation" EXACT []
synonym: "suppressor T cell differentiation" EXACT []
synonym: "suppressor T lymphocyte differentiation" EXACT []
synonym: "suppressor T-cell differentiation" EXACT []
synonym: "suppressor T-lymphocyte differentiation" EXACT []
is_a: GO:0030217 ! T cell differentiation

[Term]
id: GO:0045067
name: positive extrathymic T cell selection
namespace: biological_process
def: "The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149 "Fundamental Immunology", PMID:7880383]
synonym: "positive extrathymic T lymphocyte selection" EXACT []
synonym: "positive extrathymic T-cell selection" EXACT []
synonym: "positive extrathymic T-lymphocyte selection" EXACT []
is_a: GO:0043368 ! positive T cell selection
is_a: GO:0045062 ! extrathymic T cell selection

[Term]
id: GO:0045068
name: negative extrathymic T cell selection
namespace: biological_process
def: "The process of elimination of extrathymically maturing T cells which react strongly with self-antigens." [ISBN:0781735149 "Fundamental Immunology", PMID:7880383]
synonym: "negative extrathymic T lymphocyte selection" EXACT []
synonym: "negative extrathymic T-cell selection" EXACT []
synonym: "negative extrathymic T-lymphocyte selection" EXACT []
is_a: GO:0043383 ! negative T cell selection
is_a: GO:0045062 ! extrathymic T cell selection

[Term]
id: GO:0045069
name: regulation of viral genome replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of viral genome replication." [GOC:ai]
is_a: GO:0050792 ! regulation of viral reproduction
relationship: regulates GO:0019079 ! viral genome replication

[Term]
id: GO:0045070
name: positive regulation of viral genome replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of viral genome replication." [GOC:ai]
synonym: "activation of viral genome replication" NARROW []
synonym: "stimulation of viral genome replication" NARROW []
synonym: "up regulation of viral genome replication" EXACT []
synonym: "up-regulation of viral genome replication" EXACT []
synonym: "upregulation of viral genome replication" EXACT []
is_a: GO:0045069 ! regulation of viral genome replication
is_a: GO:0048524 ! positive regulation of viral reproduction
relationship: positively_regulates GO:0019079 ! viral genome replication

[Term]
id: GO:0045071
name: negative regulation of viral genome replication
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral genome replication." [GOC:go_curators]
synonym: "down regulation of viral genome replication" EXACT []
synonym: "down-regulation of viral genome replication" EXACT []
synonym: "downregulation of viral genome replication" EXACT []
synonym: "inhibition of viral genome replication" NARROW []
is_a: GO:0045069 ! regulation of viral genome replication
is_a: GO:0048525 ! negative regulation of viral reproduction
relationship: negatively_regulates GO:0019079 ! viral genome replication

[Term]
id: GO:0045072
name: regulation of interferon-gamma biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators]
synonym: "regulation of interferon-gamma anabolism" EXACT []
synonym: "regulation of interferon-gamma biosynthesis" EXACT []
synonym: "regulation of interferon-gamma formation" EXACT []
synonym: "regulation of interferon-gamma synthesis" EXACT []
is_a: GO:0032649 ! regulation of interferon-gamma production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042095 ! interferon-gamma biosynthetic process

[Term]
id: GO:0045073
name: regulation of chemokine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators]
synonym: "regulation of chemokine anabolism" EXACT []
synonym: "regulation of chemokine biosynthesis" EXACT []
synonym: "regulation of chemokine formation" EXACT []
synonym: "regulation of chemokine synthesis" EXACT []
is_a: GO:0032642 ! regulation of chemokine production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042033 ! chemokine biosynthetic process

[Term]
id: GO:0045074
name: regulation of interleukin-10 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators]
synonym: "regulation of IL-10 biosynthesis" EXACT []
synonym: "regulation of IL-10 biosynthetic process" EXACT []
synonym: "regulation of interleukin-10 anabolism" EXACT []
synonym: "regulation of interleukin-10 biosynthesis" EXACT []
synonym: "regulation of interleukin-10 formation" EXACT []
synonym: "regulation of interleukin-10 synthesis" EXACT []
is_a: GO:0032653 ! regulation of interleukin-10 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042091 ! interleukin-10 biosynthetic process

[Term]
id: GO:0045075
name: regulation of interleukin-12 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators]
synonym: "regulation of IL-12 biosynthesis" EXACT []
synonym: "regulation of IL-12 biosynthetic process" EXACT []
synonym: "regulation of interleukin-12 anabolism" EXACT []
synonym: "regulation of interleukin-12 biosynthesis" EXACT []
synonym: "regulation of interleukin-12 formation" EXACT []
synonym: "regulation of interleukin-12 synthesis" EXACT []
is_a: GO:0032655 ! regulation of interleukin-12 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042090 ! interleukin-12 biosynthetic process

[Term]
id: GO:0045076
name: regulation of interleukin-2 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators]
synonym: "regulation of IL-2 biosynthesis" EXACT []
synonym: "regulation of IL-2 biosynthetic process" EXACT []
synonym: "regulation of interleukin-2 anabolism" EXACT []
synonym: "regulation of interleukin-2 biosynthesis" EXACT []
synonym: "regulation of interleukin-2 formation" EXACT []
synonym: "regulation of interleukin-2 synthesis" EXACT []
is_a: GO:0032663 ! regulation of interleukin-2 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042094 ! interleukin-2 biosynthetic process

[Term]
id: GO:0045077
name: negative regulation of interferon-gamma biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators]
synonym: "down regulation of interferon-gamma biosynthetic process" EXACT []
synonym: "down-regulation of interferon-gamma biosynthetic process" EXACT []
synonym: "downregulation of interferon-gamma biosynthetic process" EXACT []
synonym: "inhibition of interferon-gamma biosynthetic process" NARROW []
synonym: "negative regulation of interferon-gamma anabolism" EXACT []
synonym: "negative regulation of interferon-gamma biosynthesis" EXACT []
synonym: "negative regulation of interferon-gamma formation" EXACT []
synonym: "negative regulation of interferon-gamma synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045072 ! regulation of interferon-gamma biosynthetic process
relationship: negatively_regulates GO:0042095 ! interferon-gamma biosynthetic process

[Term]
id: GO:0045078
name: positive regulation of interferon-gamma biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators]
synonym: "activation of interferon-gamma biosynthetic process" NARROW []
synonym: "positive regulation of interferon-gamma anabolism" EXACT []
synonym: "positive regulation of interferon-gamma biosynthesis" EXACT []
synonym: "positive regulation of interferon-gamma formation" EXACT []
synonym: "positive regulation of interferon-gamma synthesis" EXACT []
synonym: "stimulation of interferon-gamma biosynthetic process" NARROW []
synonym: "up regulation of interferon-gamma biosynthetic process" EXACT []
synonym: "up-regulation of interferon-gamma biosynthetic process" EXACT []
synonym: "upregulation of interferon-gamma biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045072 ! regulation of interferon-gamma biosynthetic process
relationship: positively_regulates GO:0042095 ! interferon-gamma biosynthetic process

[Term]
id: GO:0045079
name: negative regulation of chemokine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators]
synonym: "down regulation of chemokine biosynthetic process" EXACT []
synonym: "down-regulation of chemokine biosynthetic process" EXACT []
synonym: "downregulation of chemokine biosynthetic process" EXACT []
synonym: "inhibition of chemokine biosynthetic process" NARROW []
synonym: "negative regulation of chemokine anabolism" EXACT []
synonym: "negative regulation of chemokine biosynthesis" EXACT []
synonym: "negative regulation of chemokine formation" EXACT []
synonym: "negative regulation of chemokine synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045073 ! regulation of chemokine biosynthetic process
relationship: negatively_regulates GO:0042033 ! chemokine biosynthetic process

[Term]
id: GO:0045080
name: positive regulation of chemokine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators]
synonym: "activation of chemokine biosynthetic process" NARROW []
synonym: "positive regulation of chemokine anabolism" EXACT []
synonym: "positive regulation of chemokine biosynthesis" EXACT []
synonym: "positive regulation of chemokine formation" EXACT []
synonym: "positive regulation of chemokine synthesis" EXACT []
synonym: "stimulation of chemokine biosynthetic process" NARROW []
synonym: "up regulation of chemokine biosynthetic process" EXACT []
synonym: "up-regulation of chemokine biosynthetic process" EXACT []
synonym: "upregulation of chemokine biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045073 ! regulation of chemokine biosynthetic process
relationship: positively_regulates GO:0042033 ! chemokine biosynthetic process

[Term]
id: GO:0045081
name: negative regulation of interleukin-10 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators]
synonym: "down regulation of interleukin-10 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-10 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-10 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-10 biosynthetic process" NARROW []
synonym: "negative regulation of IL-10 biosynthesis" EXACT []
synonym: "negative regulation of IL-10 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-10 anabolism" EXACT []
synonym: "negative regulation of interleukin-10 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-10 formation" EXACT []
synonym: "negative regulation of interleukin-10 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045074 ! regulation of interleukin-10 biosynthetic process
relationship: negatively_regulates GO:0042091 ! interleukin-10 biosynthetic process

[Term]
id: GO:0045082
name: positive regulation of interleukin-10 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators]
synonym: "activation of interleukin-10 biosynthetic process" NARROW []
synonym: "positive regulation of IL-10 biosynthesis" EXACT []
synonym: "positive regulation of IL-10 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-10 anabolism" EXACT []
synonym: "positive regulation of interleukin-10 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-10 formation" EXACT []
synonym: "positive regulation of interleukin-10 synthesis" EXACT []
synonym: "stimulation of interleukin-10 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-10 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-10 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-10 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045074 ! regulation of interleukin-10 biosynthetic process
relationship: positively_regulates GO:0042091 ! interleukin-10 biosynthetic process

[Term]
id: GO:0045083
name: negative regulation of interleukin-12 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators]
synonym: "down regulation of interleukin-12 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-12 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-12 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-12 biosynthetic process" NARROW []
synonym: "negative regulation of IL-12 biosynthesis" EXACT []
synonym: "negative regulation of IL-12 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-12 anabolism" EXACT []
synonym: "negative regulation of interleukin-12 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-12 formation" EXACT []
synonym: "negative regulation of interleukin-12 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045075 ! regulation of interleukin-12 biosynthetic process
relationship: negatively_regulates GO:0042090 ! interleukin-12 biosynthetic process

[Term]
id: GO:0045084
name: positive regulation of interleukin-12 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators]
synonym: "activation of interleukin-12 biosynthetic process" NARROW []
synonym: "positive regulation of IL-12 biosynthesis" EXACT []
synonym: "positive regulation of IL-12 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-12 anabolism" EXACT []
synonym: "positive regulation of interleukin-12 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-12 formation" EXACT []
synonym: "positive regulation of interleukin-12 synthesis" EXACT []
synonym: "stimulation of interleukin-12 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-12 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-12 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-12 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045075 ! regulation of interleukin-12 biosynthetic process
relationship: positively_regulates GO:0042090 ! interleukin-12 biosynthetic process

[Term]
id: GO:0045085
name: negative regulation of interleukin-2 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators]
synonym: "down regulation of interleukin-2 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-2 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-2 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-2 biosynthetic process" NARROW []
synonym: "negative regulation of IL-2 biosynthesis" EXACT []
synonym: "negative regulation of IL-2 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-2 anabolism" EXACT []
synonym: "negative regulation of interleukin-2 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-2 formation" EXACT []
synonym: "negative regulation of interleukin-2 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045076 ! regulation of interleukin-2 biosynthetic process
relationship: negatively_regulates GO:0042094 ! interleukin-2 biosynthetic process

[Term]
id: GO:0045086
name: positive regulation of interleukin-2 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators]
synonym: "activation of interleukin-2 biosynthetic process" NARROW []
synonym: "positive regulation of IL-2 biosynthesis" EXACT []
synonym: "positive regulation of IL-2 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-2 anabolism" EXACT []
synonym: "positive regulation of interleukin-2 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-2 formation" EXACT []
synonym: "positive regulation of interleukin-2 synthesis" EXACT []
synonym: "stimulation of interleukin-2 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-2 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-2 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-2 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045076 ! regulation of interleukin-2 biosynthetic process
relationship: positively_regulates GO:0042094 ! interleukin-2 biosynthetic process

[Term]
id: GO:0045087
name: innate immune response
namespace: biological_process
alt_id: GO:0002226
def: "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]
comment: This term was improved by GO_REF:0000022. It was moved.
synonym: "nonspecific immune response" EXACT []
xref: Reactome:168249 "Innate Immunity Signaling"
xref: Reactome:448672 "Innate Immunity Signaling"
xref: Reactome:469811 "Innate Immunity Signaling"
xref: Reactome:487494 "Innate Immunity Signaling"
xref: Reactome:507465 "Innate Immunity Signaling"
xref: Reactome:517859 "Innate Immunity Signaling"
xref: Reactome:531464 "Innate Immunity Signaling"
xref: Reactome:536848 "Innate Immunity Signaling"
xref: Reactome:542476 "Innate Immunity Signaling"
xref: Reactome:547920 "Innate Immunity Signaling"
xref: Wikipedia:Innate_immune_system
is_a: GO:0006952 ! defense response
is_a: GO:0006955 ! immune response

[Term]
id: GO:0045088
name: regulation of innate immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0045087 ! innate immune response

[Term]
id: GO:0045089
name: positive regulation of innate immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]
synonym: "stimulation of innate immune response" NARROW []
synonym: "up regulation of innate immune response" EXACT []
synonym: "up-regulation of innate immune response" EXACT []
synonym: "upregulation of innate immune response" EXACT []
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0050778 ! positive regulation of immune response
relationship: positively_regulates GO:0045087 ! innate immune response

[Term]
id: GO:0045090
name: retroviral genome replication
namespace: biological_process
def: "Any process involved in the replication of a retroviral genome. Retroviruses use RNA as their nucleic acid and reverse transcriptase to copy their genome into the DNA of the host cells chromosomes." [GOC:go_curators, http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0019079 ! viral genome replication

[Term]
id: GO:0045091
name: regulation of retroviral genome replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retroviral genome replication." [GOC:go_curators]
is_a: GO:0045069 ! regulation of viral genome replication
relationship: regulates GO:0045090 ! retroviral genome replication

[Term]
id: GO:0045092
name: interleukin-18 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-18; comprises an alpha and a beta subunit." [GOC:mah, PMID:12759435]
synonym: "IL-18 receptor complex" EXACT [GOC:add]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0045093
name: interleukin-18 alpha subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the alpha subunit of interleukin-18. IL-18a is a component of IL-18 that is essential for IL-18 binding on the surface of T-helper 1 cells." [PMID:10653850]
synonym: "IL-18Ra binding" EXACT []
is_a: GO:0042007 ! interleukin-18 binding

[Term]
id: GO:0045094
name: interleukin-18 beta subunit binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the beta subunit of interleukin-18. IL-18b is a ligand non-binding chain and is required for signaling of IL-18 that binds with IL-18a." [PMID:10653850]
synonym: "IL-18Rb binding" EXACT []
is_a: GO:0042007 ! interleukin-18 binding

[Term]
id: GO:0045095
name: keratin filament
namespace: cellular_component
def: "A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." [ISBN:0716731363]
synonym: "acidic keratin" RELATED []
synonym: "basic/neutral keratin" RELATED []
is_a: GO:0005882 ! intermediate filament

[Term]
id: GO:0045096
name: acidic keratin
namespace: cellular_component
def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363, ISBN:0815316194]
comment: This term was made obsolete because it represents a gene product.
synonym: "type I intermediate filament" EXACT []
is_obsolete: true
replaced_by: GO:0045095

[Term]
id: GO:0045097
name: basic/neutral keratin
namespace: cellular_component
def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363, ISBN:0815316194]
comment: This term was made obsolete because it represents a gene product.
synonym: "type II intermediate filament" EXACT []
is_obsolete: true
replaced_by: GO:0045095

[Term]
id: GO:0045098
name: type III intermediate filament
namespace: cellular_component
def: "A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments." [ISBN:0716731363]
synonym: "desmin" NARROW []
synonym: "glial fibrillary acidic protein" NARROW []
synonym: "peripherin" NARROW []
synonym: "type III intermediate filament associated protein" NARROW []
synonym: "vimentin" NARROW []
is_a: GO:0005882 ! intermediate filament

[Term]
id: GO:0045099
name: vimentin
namespace: cellular_component
def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0045098

[Term]
id: GO:0045100
name: desmin
namespace: cellular_component
def: "OBSOLETE. A type of intermediate filament." [ISBN:0815316194]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0045098

[Term]
id: GO:0045101
name: glial fibrillary acidic protein
namespace: cellular_component
def: "OBSOLETE. Glial fibrillary acidic protein forms filaments in the glial cells that surround neurons and in astrocytes." [ISBN:0716731363]
comment: This term was made obsolete because it represents a gene product.
synonym: "GFAP" EXACT []
is_obsolete: true
consider: GO:0045098

[Term]
id: GO:0045102
name: peripherin
namespace: cellular_component
def: "OBSOLETE. Peripherin is a type III intermediate filament protein found in neurons of the peripheral nervous system." [ISBN:0716731363]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
consider: GO:0045098

[Term]
id: GO:0045103
name: intermediate filament-based process
namespace: biological_process
def: "Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins." [GOC:ai]
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0045104
name: intermediate filament cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai]
synonym: "intermediate filament cytoskeleton organisation" EXACT [GOC:curators]
synonym: "intermediate filament cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0045103 ! intermediate filament-based process

[Term]
id: GO:0045105
name: intermediate filament polymerization or depolymerization
namespace: biological_process
def: "Assembly or disassembly of intermediate filaments by the addition or removal of component parts from a filament." [GOC:ai]
is_a: GO:0034621 ! cellular macromolecular complex subunit organization
relationship: part_of GO:0045104 ! intermediate filament cytoskeleton organization

[Term]
id: GO:0045106
name: intermediate filament depolymerization
namespace: biological_process
def: "Disassembly of intermediate filaments by the removal of component monomers from a filament." [GOC:mah, ISBN:0716731363]
is_a: GO:0045105 ! intermediate filament polymerization or depolymerization
is_a: GO:0051261 ! protein depolymerization

[Term]
id: GO:0045107
name: intermediate filament polymerization
namespace: biological_process
def: "Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain." [GOC:mah, PMID:8776884]
is_a: GO:0045105 ! intermediate filament polymerization or depolymerization
is_a: GO:0051258 ! protein polymerization

[Term]
id: GO:0045108
name: regulation of intermediate filament polymerization or depolymerization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly or disassembly of intermediate filaments by the addition or removal of monomers from a filament; this usually occurs through the opposing action of kinases and phosphatases." [ISBN:0716731363]
is_a: GO:0051493 ! regulation of cytoskeleton organization
relationship: regulates GO:0045105 ! intermediate filament polymerization or depolymerization

[Term]
id: GO:0045109
name: intermediate filament organization
namespace: biological_process
def: "Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:ai]
synonym: "intermediate filament organisation" EXACT [GOC:curators]
is_a: GO:0045104 ! intermediate filament cytoskeleton organization

[Term]
id: GO:0045110
name: intermediate filament bundle assembly
namespace: biological_process
def: "The formation of the bundles of intermediate filaments, known as tonofilaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs." [ISBN:0716731363]
synonym: "tonofilament assembly" NARROW []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0045109 ! intermediate filament organization

[Term]
id: GO:0045111
name: intermediate filament cytoskeleton
namespace: cellular_component
def: "Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell." [ISBN:0716731363]
is_a: GO:0005856 ! cytoskeleton

[Term]
id: GO:0045112
name: integrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "integrin anabolism" EXACT []
synonym: "integrin biosynthesis" EXACT []
synonym: "integrin formation" EXACT []
synonym: "integrin synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process
relationship: part_of GO:0007009 ! plasma membrane organization

[Term]
id: GO:0045113
name: regulation of integrin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators]
synonym: "regulation of integrin anabolism" EXACT []
synonym: "regulation of integrin biosynthesis" EXACT []
synonym: "regulation of integrin formation" EXACT []
synonym: "regulation of integrin synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0045112 ! integrin biosynthetic process

[Term]
id: GO:0045114
name: beta 2 integrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta 2 integrins, a subfamily of integrins which contain the beta 2 subunit." [GOC:go_curators]
synonym: "beta 2 integrin anabolism" EXACT []
synonym: "beta 2 integrin biosynthesis" EXACT []
synonym: "beta 2 integrin formation" EXACT []
synonym: "beta 2 integrin synthesis" EXACT []
is_a: GO:0045112 ! integrin biosynthetic process

[Term]
id: GO:0045115
name: regulation of beta 2 integrin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators]
synonym: "regulation of beta 2 integrin anabolism" EXACT []
synonym: "regulation of beta 2 integrin biosynthesis" EXACT []
synonym: "regulation of beta 2 integrin formation" EXACT []
synonym: "regulation of beta 2 integrin synthesis" EXACT []
is_a: GO:0045113 ! regulation of integrin biosynthetic process
relationship: regulates GO:0045114 ! beta 2 integrin biosynthetic process

[Term]
id: GO:0045116
name: protein neddylation
namespace: biological_process
alt_id: GO:0019943
def: "Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]
comment: Note that currently, the only known substrates of neddylation are cullin family proteins.
synonym: "RUB1-protein conjugation" EXACT []
is_a: GO:0032446 ! protein modification by small protein conjugation
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0045117
name: azole transport
namespace: biological_process
def: "The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
is_a: GO:0015893 ! drug transport

[Term]
id: GO:0045118
name: azole transporter activity
namespace: molecular_function
def: "Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, into, out of, within or between cells." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
is_a: GO:0015238 ! drug transmembrane transporter activity

[Term]
id: GO:0045119
name: azole:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances." [GOC:ai, http://cancerweb.ncl.ac.uk/]
synonym: "azole:proton antiporter activity" EXACT [GOC:mah]
synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" NARROW []
is_a: GO:0015307 ! drug:hydrogen antiporter activity
is_a: GO:0045118 ! azole transporter activity

[Term]
id: GO:0045120
name: pronucleus
namespace: cellular_component
def: "The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
xref: Wikipedia:Pronucleus
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0045121
name: membrane raft
namespace: cellular_component
def: "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198]
synonym: "GEM domain" RELATED []
synonym: "glycolipid-enriched membrane domain" RELATED []
synonym: "lipid raft" EXACT []
xref: Wikipedia:Lipid_raft
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0045122
name: aflatoxin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [ISBN:0716731363, ISBN:0815316194]
subset: gosubset_prok
synonym: "aflatoxin anabolism" EXACT []
synonym: "aflatoxin biosynthesis" EXACT []
synonym: "aflatoxin formation" EXACT []
synonym: "aflatoxin synthesis" EXACT []
is_a: GO:0009805 ! coumarin biosynthetic process
is_a: GO:0043386 ! mycotoxin biosynthetic process
is_a: GO:0046222 ! aflatoxin metabolic process

[Term]
id: GO:0045123
name: cellular extravasation
namespace: biological_process
def: "The migration of a leukocyte from the blood vessels into the surrounding tissue." [GOC:jl]
synonym: "immune cell cellular extravasation" EXACT []
synonym: "leucocyte cellular extravasation" EXACT []
synonym: "leukocyte cellular extravasation" EXACT []
synonym: "transendothelial leukocyte migration" EXACT [GOC:rl]
xref: Wikipedia:Leukocyte_extravasation
is_a: GO:0050900 ! leukocyte migration

[Term]
id: GO:0045124
name: regulation of bone resorption
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption)." [GOC:ai]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0046850 ! regulation of bone remodeling
relationship: regulates GO:0045453 ! bone resorption

[Term]
id: GO:0045125
name: bioactive lipid receptor activity
namespace: molecular_function
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0045127
name: N-acetylglucosamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate." [EC:2.7.1.59]
subset: gosubset_prok
synonym: "2-acetylamino-2-deoxy-D-glucose kinase activity" EXACT [EC:2.7.1.59]
synonym: "acetylaminodeoxyglucokinase activity" EXACT [EC:2.7.1.59]
synonym: "acetylglucosamine kinase (phosphorylating)" EXACT [EC:2.7.1.59]
synonym: "ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.59]
synonym: "ATP:N-acetyl-D-glucosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.59]
synonym: "GlcNAc kinase activity" EXACT [EC:2.7.1.59]
xref: EC:2.7.1.59
xref: MetaCyc:N-ACETYLGLUCOSAMINE-KINASE-RXN
is_a: GO:0019200 ! carbohydrate kinase activity

[Term]
id: GO:0045128
name: negative regulation of reciprocal meiotic recombination
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:ai, GOC:dph, GOC:tb]
synonym: "down regulation of meiotic recombination" EXACT []
synonym: "down-regulation of meiotic recombination" EXACT []
synonym: "downregulation of meiotic recombination" EXACT []
synonym: "inhibition of meiotic recombination" NARROW []
synonym: "suppression of meiotic recombination" EXACT []
is_a: GO:0010520 ! regulation of reciprocal meiotic recombination
is_a: GO:0045835 ! negative regulation of meiosis
is_a: GO:0045910 ! negative regulation of DNA recombination
relationship: negatively_regulates GO:0007131 ! reciprocal meiotic recombination

[Term]
id: GO:0045129
name: NAD-independent histone deacetylase activity
namespace: molecular_function
def: "Catalysis of the removal of one or more acetyl groups from a histone, independently of NAD." [GOC:ai, GOC:mah]
synonym: "AcuC" RELATED []
is_a: GO:0004407 ! histone deacetylase activity

[Term]
id: GO:0045130
name: keratan sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate." [EC:2.8.2.21]
synonym: "3'-phosphoadenylyl keratan sulfotransferase activity" EXACT [EC:2.8.2.21]
synonym: "3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase activity" EXACT [EC:2.8.2.21]
synonym: "3'-phosphoadenylylsulfate:keratan sulfotransferase activity" EXACT [EC:2.8.2.21]
synonym: "keratan sulfate Gal-6-sulfotransferase activity" EXACT []
synonym: "keratan sulfate sulfotransferase activity" EXACT [EC:2.8.2.21]
synonym: "keratan sulphotransferase activity" EXACT []
xref: EC:2.8.2.21
xref: MetaCyc:KERATAN-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0045131
name: pre-mRNA branch point binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a pre-mRNA branch point sequence, located upstream of the 3' splice site." [PMID:11691992, PMID:9722632]
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:0045132
name: meiotic chromosome segregation
namespace: biological_process
def: "The process by which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah]
is_a: GO:0007059 ! chromosome segregation
relationship: part_of GO:0007126 ! meiosis

[Term]
id: GO:0045133
name: 2,3-dihydroxybenzoate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + O2 = 3-carboxy-2-hydroxymuconate semialdehyde." [EC:1.13.11.14]
synonym: "2,3-dihydroxybenzoate 1,2-dioxygenase activity" EXACT [EC:1.13.11.14]
synonym: "2,3-dihydroxybenzoate oxygenase activity" EXACT [EC:1.13.11.14]
synonym: "2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.14]
synonym: "2,3-dihydroxybenzoic oxygenase activity" EXACT [EC:1.13.11.14]
synonym: "o-pyrocatechuate oxygenase activity" EXACT [EC:1.13.11.14]
xref: EC:1.13.11.14
xref: MetaCyc:1.13.11.14-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0045134
name: uridine-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP + H2O = UMP + phosphate." [EC:3.6.1.6]
synonym: "UDPase activity" EXACT [EC:3.6.1.6]
synonym: "uridine 5'-diphosphatase activity" EXACT [EC:3.6.1.6]
synonym: "uridine diphosphatase activity" EXACT [EC:3.6.1.6]
is_a: GO:0017110 ! nucleoside-diphosphatase activity

[Term]
id: GO:0045135
name: poly(beta-D-mannuronate) lyase activity
namespace: molecular_function
def: "Catalysis of the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends." [EC:4.2.2.3]
subset: gosubset_prok
synonym: "alginase activity" EXACT [EC:4.2.2.3]
synonym: "alginase I" RELATED [EC:4.2.2.3]
synonym: "alginate lyase activity" EXACT [EC:4.2.2.3]
synonym: "alginate lyase I activity" NARROW [EC:4.2.2.3]
synonym: "poly(beta-D-1,4-mannuronide) lyase activity" EXACT [EC:4.2.2.3]
synonym: "poly(mana) alginate lyase activity" NARROW [EC:4.2.2.3]
xref: EC:4.2.2.3
xref: MetaCyc:4.2.2.3-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0045136
name: development of secondary sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion." [GOC:ai]
is_a: GO:0003006 ! reproductive developmental process
relationship: part_of GO:0007275 ! multicellular organismal development
relationship: part_of GO:0007548 ! sex differentiation

[Term]
id: GO:0045137
name: development of primary sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion." [GOC:ai]
is_a: GO:0003006 ! reproductive developmental process
relationship: part_of GO:0007275 ! multicellular organismal development
relationship: part_of GO:0007548 ! sex differentiation

[Term]
id: GO:0045138
name: tail tip morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the tail tip are generated and organized. Morphogenesis pertains to the creation of form. The tail tip undergoes morphogenesis to form a copulatory structure. The most posterior hypodermal cells in the tail define a specialized, sexually dimorphic compartment in which cells fuse and retract in the male, changing their shape from a tapered cone to a blunt dome. An example of this process is found in Caenorhabditis elegans." [PMID:10049567]
synonym: "male tail morphogenesis" BROAD []
is_a: GO:0035121 ! tail morphogenesis

[Term]
id: GO:0045139
name: copper sensitivity/resistance
namespace: biological_process
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators]
comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process.
is_obsolete: true
replaced_by: GO:0046688

[Term]
id: GO:0045140
name: inositol phosphoceramide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide." [MetaCyc:RXN3O-581, PMID:9405490, PMID:9614099]
synonym: "IPC synthase activity" EXACT []
xref: EC:2.4.1.-
xref: MetaCyc:RXN3O-581
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0045141
name: meiotic telomere clustering
namespace: biological_process
def: "The cell cycle process whereby the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in homologous chromosome pairing and therefore progression through meiosis." [GOC:vw, PMID:10690419]
synonym: "bouquet biosynthesis" NARROW []
synonym: "bouquet formation" NARROW []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0034397 ! telomere localization
relationship: part_of GO:0007126 ! meiosis

[Term]
id: GO:0045142
name: triplex DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination." [PMID:10681538]
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0045143
name: homologous chromosome segregation
namespace: biological_process
alt_id: GO:0007061
def: "The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, ISBN:0815316194]
synonym: "meiosis I, chromosome segregation" EXACT []
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007127 ! meiosis I
relationship: part_of GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0045144
name: meiotic sister chromatid segregation
namespace: biological_process
def: "The cell cycle process whereby sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194]
synonym: "meiosis II, chromosome segregation" EXACT []
is_a: GO:0000819 ! sister chromatid segregation
relationship: part_of GO:0007135 ! meiosis II
relationship: part_of GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0045145
name: single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule." [GOC:ai, GOC:elh, PMID:20086101]
synonym: "ssDNA-specific 5'-3' exodeoxyribonuclease activity" EXACT [GOC:mah]
is_a: GO:0008297 ! single-stranded DNA specific exodeoxyribonuclease activity
is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity

[Term]
id: GO:0045146
name: initiation of acetate catabolic process by acetate
namespace: biological_process
def: "The activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [PMID:11741859]
subset: gosubset_prok
synonym: "initiation of acetate breakdown by acetate" EXACT []
synonym: "initiation of acetate degradation by acetate" EXACT []
is_a: GO:0010034 ! response to acetate
is_a: GO:0043077 ! initiation of acetate catabolic process

[Term]
id: GO:0045147
name: regulation of initiation of acetate catabolic process by acetate
namespace: biological_process
def: "Any process that modulates the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of initiation of acetate breakdown by acetate" EXACT []
synonym: "regulation of initiation of acetate degradation by acetate" EXACT []
is_a: GO:0045734 ! regulation of acetate catabolic process
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0045146 ! initiation of acetate catabolic process by acetate

[Term]
id: GO:0045148
name: tripeptide aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the release of the N-terminal residue from a tripeptide." [EC:3.4.11.4]
subset: gosubset_prok
synonym: "alanine-phenylalanine-proline arylamidase activity" EXACT [EC:3.4.11.4]
synonym: "aminoexotripeptidase activity" EXACT [EC:3.4.11.4]
synonym: "aminotripeptidase activity" EXACT []
synonym: "imidoendopeptidase activity" EXACT [EC:3.4.11.4]
synonym: "lymphopeptidase activity" EXACT [EC:3.4.11.4]
synonym: "peptidase B" RELATED [EC:3.4.11.4]
synonym: "peptidase T" EXACT []
xref: EC:3.4.11.4
xref: MetaCyc:3.4.11.4-RXN
is_a: GO:0004177 ! aminopeptidase activity
is_a: GO:0034701 ! tripeptidase activity

[Term]
id: GO:0045149
name: acetoin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving acetoin, 3-hydroxy-2-butanone, often as part of a fermentation pathway or for use as a carbon source." [GOC:mlg]
subset: gosubset_prok
synonym: "acetoin metabolism" EXACT []
is_a: GO:0042180 ! cellular ketone metabolic process

[Term]
id: GO:0045150
name: acetoin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone." [GOC:mlg]
subset: gosubset_prok
synonym: "acetoin breakdown" EXACT []
synonym: "acetoin catabolism" EXACT []
synonym: "acetoin degradation" EXACT []
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0045149 ! acetoin metabolic process

[Term]
id: GO:0045151
name: acetoin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetoin, 3-hydroxy-2-butanone." [GOC:mlg]
subset: gosubset_prok
synonym: "acetoin anabolism" EXACT []
synonym: "acetoin biosynthesis" EXACT []
synonym: "acetoin formation" EXACT []
synonym: "acetoin synthesis" EXACT []
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0045149 ! acetoin metabolic process

[Term]
id: GO:0045152
name: antisigma factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator." [GOC:mlg]
subset: gosubset_prok
synonym: "antisigma factor antagonist activity" NARROW []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045153
name: electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity
namespace: molecular_function
def: "Enables the directed movement of electrons within the CoQH2-cytochrome c reductase complex." [GOC:ai, ISBN:0716731363]
synonym: "cytochrome" RELATED []
synonym: "cytochrome b562" NARROW []
synonym: "cytochrome b566" NARROW []
synonym: "cytochrome c1" NARROW []
synonym: "soluble cytochrome b562" RELATED []
xref: Reactome:19911 "electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity"
is_a: GO:0009055 ! electron carrier activity

[Term]
id: GO:0045154
name: electron transporter, transferring electrons within cytochrome c oxidase complex activity
namespace: molecular_function
def: "Enables the directed movement of electrons within the cytochrome c oxidase complex." [GOC:ai, ISBN:0716731363]
synonym: "cytochrome" RELATED []
synonym: "cytochrome a" NARROW []
synonym: "cytochrome a3/copper complex" NARROW []
is_a: GO:0009055 ! electron carrier activity

[Term]
id: GO:0045155
name: electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
namespace: molecular_function
def: "Enables the directed movement of electrons from the CoQH2-cytochrome c reductase complex and the cytochrome c oxidase complex." [GOC:ai, ISBN:0716731363]
subset: gosubset_prok
synonym: "cytochrome" RELATED []
synonym: "cytochrome c" NARROW []
is_a: GO:0009055 ! electron carrier activity

[Term]
id: GO:0045156
name: electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
namespace: molecular_function
def: "Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363]
subset: gosubset_prok
synonym: "cytochrome" RELATED []
synonym: "cytochrome bc1 complex" NARROW []
is_a: GO:0009055 ! electron carrier activity

[Term]
id: GO:0045157
name: electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity
namespace: molecular_function
def: "Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363]
synonym: "cytochrome" RELATED []
is_a: GO:0009055 ! electron carrier activity

[Term]
id: GO:0045158
name: electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity
namespace: molecular_function
def: "Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363]
subset: gosubset_prok
synonym: "cytochrome" RELATED []
synonym: "cytochrome b/b6" RELATED []
synonym: "cytochrome b6" NARROW []
synonym: "cytochrome f" NARROW []
is_a: GO:0009055 ! electron carrier activity

[Term]
id: GO:0045159
name: myosin II binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0045160
name: myosin I complex
namespace: cellular_component
def: "A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:9438839]
is_a: GO:0016461 ! unconventional myosin complex

[Term]
id: GO:0045161
name: neuronal ion channel clustering
namespace: biological_process
def: "The process by which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation." [PMID:11456440]
is_a: GO:0016044 ! cellular membrane organization
relationship: part_of GO:0042551 ! neuron maturation

[Term]
id: GO:0045162
name: clustering of voltage-gated sodium channels
namespace: biological_process
def: "The process by which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization." [PMID:11456440]
synonym: "clustering of voltage gated sodium channels" EXACT []
synonym: "clustering of voltage-dependent sodium channels" EXACT []
synonym: "Nav channel clustering" EXACT []
synonym: "voltage-gated sodium channel clustering" EXACT []
is_a: GO:0045161 ! neuronal ion channel clustering

[Term]
id: GO:0045163
name: clustering of voltage-gated potassium channels
namespace: biological_process
def: "The process by which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode." [PMID:11456440]
synonym: "clustering of voltage gated potassium channels" EXACT []
synonym: "clustering of voltage-dependent potassium channels" EXACT []
synonym: "Kv channel clustering" EXACT []
synonym: "voltage-gated potassium channel clustering" EXACT []
is_a: GO:0045161 ! neuronal ion channel clustering

[Term]
id: GO:0045164
name: secretin (sensu Mammalia)
namespace: molecular_function
def: "OBSOLETE. Secretin is a hormone that takes part in the digestion process. It also has effects on organs other than gastrointestinal tract." [PMID:11320551]
comment: This term was made obsolete because it represents a gene product rather than a molecular function.
is_obsolete: true
consider: GO:0046659

[Term]
id: GO:0045165
name: cell fate commitment
namespace: biological_process
def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185]
comment: Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created.
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0030154 ! cell differentiation

[Term]
id: GO:0045167
name: asymmetric protein localization involved in cell fate determination
namespace: biological_process
def: "Any process by which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai]
synonym: "asymmetric protein localization involved in cell fate commitment" EXACT []
synonym: "asymmetric protein localization resulting in cell fate commitment" EXACT []
synonym: "cell fate commitment, asymmetric protein localization" EXACT []
is_a: GO:0008105 ! asymmetric protein localization
relationship: part_of GO:0001709 ! cell fate determination

[Term]
id: GO:0045168
name: cell-cell signaling involved in cell fate specification
namespace: biological_process
def: "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "cell fate commitment, cell-cell signaling" EXACT []
synonym: "cell fate commitment, cell-cell signalling" EXACT []
synonym: "cell-cell signaling involved in cell fate commitment" EXACT []
synonym: "cell-cell signaling resulting in cell fate commitment" EXACT []
synonym: "cell-cell signalling during cell fate commitment" EXACT []
synonym: "cell-cell signalling involved in cell fate commitment" EXACT []
synonym: "cell-cell signalling resulting in cell fate commitment" EXACT []
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0001708 ! cell fate specification

[Term]
id: GO:0045169
name: fusome
namespace: cellular_component
def: "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045170
name: spectrosome
namespace: cellular_component
def: "A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome." [GOC:bf]
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045171
name: intercellular bridge
namespace: cellular_component
def: "A direct link between the cytoplasms of sister cells that allows cells to communicate with one another. Germline intercellular bridges facilitate the passage of cytoplasmic components between cells during development. Intercellular bridges have also been found connecting somatic cells." [PMID:9635420]
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0045172
name: germline ring canal
namespace: cellular_component
def: "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801]
is_a: GO:0045171 ! intercellular bridge

[Term]
id: GO:0045173
name: O-sialoglycoprotein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "O-sialoglycoprotein breakdown" EXACT []
synonym: "O-sialoglycoprotein catabolism" EXACT []
synonym: "O-sialoglycoprotein degradation" EXACT []
is_a: GO:0006516 ! glycoprotein catabolic process

[Term]
id: GO:0045174
name: glutathione dehydrogenase (ascorbate) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate." [EC:1.8.5.1]
synonym: "dehydroascorbate reductase activity" EXACT []
synonym: "dehydroascorbic acid reductase activity" EXACT [EC:1.8.5.1]
synonym: "dehydroascorbic reductase activity" EXACT [EC:1.8.5.1]
synonym: "DHA reductase activity" EXACT [EC:1.8.5.1]
synonym: "GDOR" RELATED [EC:1.8.5.1]
synonym: "glutathione dehydroascorbate reductase activity" EXACT [EC:1.8.5.1]
synonym: "glutathione:dehydroascorbate oxidoreductase activity" EXACT [EC:1.8.5.1]
synonym: "glutathione:dehydroascorbic acid oxidoreductase activity" EXACT [EC:1.8.5.1]
xref: EC:1.8.5.1
xref: MetaCyc:1.8.5.1-RXN
xref: Reactome:20045 "glutathione dehydrogenase (ascorbate) activity"
is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016672 ! oxidoreductase activity, acting on sulfur group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0045175
name: basal protein localization
namespace: biological_process
def: "Any process by which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf]
synonym: "establishment and maintenance of basal protein localization" EXACT []
synonym: "establishment and maintenance of protein localization in basal part of cell" EXACT []
is_a: GO:0008105 ! asymmetric protein localization

[Term]
id: GO:0045176
name: apical protein localization
namespace: biological_process
def: "Any process by which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf]
synonym: "establishment and maintenance of apical protein localization" EXACT []
synonym: "establishment and maintenance of protein localization in apical part of cell" EXACT []
is_a: GO:0008105 ! asymmetric protein localization

[Term]
id: GO:0045177
name: apical part of cell
namespace: cellular_component
def: "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]
subset: goslim_pir
is_a: GO:0044464 ! cell part

[Term]
id: GO:0045178
name: basal part of cell
namespace: cellular_component
def: "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:bmah, ISBN:0185316194]
subset: goslim_pir
is_a: GO:0044464 ! cell part

[Term]
id: GO:0045179
name: apical cortex
namespace: cellular_component
def: "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf]
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0045177 ! apical part of cell

[Term]
id: GO:0045180
name: basal cortex
namespace: cellular_component
def: "The region that lies just beneath the plasma membrane on the basal edge of a cell." [GOC:bf]
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0045178 ! basal part of cell

[Term]
id: GO:0045181
name: glutamate synthase activity, NADH or NADPH as acceptor
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+." [EC:1.4.1.13, EC:1.4.1.14]
subset: gosubset_prok
xref: EC:1.4.1.-
is_a: GO:0015930 ! glutamate synthase activity
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0045182
name: translation regulator activity
namespace: molecular_function
def: "Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai]
subset: goslim_candida
subset: goslim_generic
subset: goslim_goa
subset: goslim_pir
subset: goslim_plant
subset: goslim_yeast
subset: gosubset_prok
synonym: "translation factor activity" EXACT []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0045183
name: translation factor activity, non-nucleic acid binding
namespace: molecular_function
def: "A translation regulator activity that does not involve binding to nucleic acids." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
is_a: GO:0045182 ! translation regulator activity

[Term]
id: GO:0045184
name: establishment of protein localization
namespace: biological_process
def: "The directed movement of a protein to a specific location." [GOC:bf]
subset: gosubset_prok
synonym: "protein positioning" EXACT []
synonym: "protein recruitment" EXACT []
is_a: GO:0051234 ! establishment of localization
relationship: part_of GO:0008104 ! protein localization

[Term]
id: GO:0045185
name: maintenance of protein location
namespace: biological_process
def: "Any process by which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf]
subset: gosubset_prok
synonym: "active protein retrieval" NARROW []
synonym: "maintenance of protein localization" RELATED [GOC:dph, GOC:tb]
synonym: "protein retention" NARROW []
synonym: "protein sequestering" NARROW []
is_a: GO:0051235 ! maintenance of location
relationship: part_of GO:0008104 ! protein localization

[Term]
id: GO:0045186
name: zonula adherens assembly
namespace: biological_process
def: "Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf]
is_a: GO:0007043 ! cell-cell junction assembly
relationship: part_of GO:0043297 ! apical junction assembly

[Term]
id: GO:0045187
name: regulation of circadian sleep/wake cycle, sleep
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981]
synonym: "regulation of sleep" EXACT []
is_a: GO:0042749 ! regulation of circadian sleep/wake cycle
relationship: regulates GO:0050802 ! circadian sleep/wake cycle, sleep

[Term]
id: GO:0045188
name: regulation of circadian sleep/wake cycle, non-REM sleep
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep." [GOC:go_curators]
synonym: "regulation of non-REM sleep" EXACT []
is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep
relationship: regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep

[Term]
id: GO:0045189
name: connective tissue growth factor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGF-beta." [http://www.copewithcytokines.de]
synonym: "connective tissue growth factor anabolism" EXACT []
synonym: "connective tissue growth factor biosynthesis" EXACT []
synonym: "connective tissue growth factor formation" EXACT []
synonym: "connective tissue growth factor synthesis" EXACT []
synonym: "CTGF biosynthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032601 ! connective tissue growth factor production

[Term]
id: GO:0045190
name: isotype switching
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus." [http://cancerweb.ncl.ac.uk/, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.
synonym: "class switch recombination" EXACT []
synonym: "class switching" EXACT []
synonym: "isotype switch recombination" EXACT []
xref: Wikipedia:Immunoglobulin_class_switching
is_a: GO:0002204 ! somatic recombination of immunoglobulin genes during immune response
is_a: GO:0042113 ! B cell activation

[Term]
id: GO:0045191
name: regulation of isotype switching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isotype switching." [GOC:ai]
synonym: "regulation of class switch recombination" EXACT []
synonym: "regulation of class switching" EXACT []
synonym: "regulation of isotype switch recombination" EXACT []
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0050864 ! regulation of B cell activation
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0045190 ! isotype switching

[Term]
id: GO:0045192
name: low-density lipoprotein catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of low-density lipoproteins, also known as beta lipoproteins, one of the classes of lipoproteins found in the bloodstream of animals, acting as a carrier for cholesterol and fats." [GOC:go_curators, http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds.
synonym: "LDL catabolic process" EXACT []
synonym: "LDL catabolism" EXACT []
synonym: "low-density lipoprotein breakdown" EXACT []
synonym: "low-density lipoprotein catabolism" EXACT []
synonym: "low-density lipoprotein degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0045193
name: acetylated low-density lipoprotein catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetylated low-density lipoproteins." [GOC:go_curators]
comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds.
synonym: "Ac-LDL catabolic process" EXACT []
synonym: "Ac-LDL catabolism" EXACT []
synonym: "acetylated low-density lipoprotein breakdown" EXACT []
synonym: "acetylated low-density lipoprotein catabolism" EXACT []
synonym: "acetylated low-density lipoprotein degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0045194
name: oxidized low-density lipoprotein catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of oxidized low-density lipoproteins." [GOC:go_curators]
comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds.
synonym: "Ox-LDL catabolic process" EXACT []
synonym: "Ox-LDL catabolism" EXACT []
synonym: "oxidized low-density lipoprotein breakdown" EXACT []
synonym: "oxidized low-density lipoprotein catabolism" EXACT []
synonym: "oxidized low-density lipoprotein degradation" EXACT []
is_obsolete: true

[Term]
id: GO:0045195
name: gallstone formation
namespace: biological_process
def: "OBSOLETE. The formation of gallstones, hard, crystal-like accretions of cholesterol and bile pigments which develop when bile contains too much cholesterol and not enough bile." [http://www.ddc.musc.edu/ddc_pro/pro_development/basic_science/gallstones.htm]
comment: This term was made obsolete because the process it represents is pathological.
is_obsolete: true

[Term]
id: GO:0045196
name: establishment or maintenance of neuroblast polarity
namespace: biological_process
alt_id: GO:0043339
alt_id: GO:0043342
def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu]
synonym: "establishment and/or maintenance of neuroblast cell polarity" EXACT []
is_a: GO:0007163 ! establishment or maintenance of cell polarity

[Term]
id: GO:0045197
name: establishment or maintenance of epithelial cell apical/basal polarity
namespace: biological_process
def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]
is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity

[Term]
id: GO:0045198
name: establishment of epithelial cell apical/basal polarity
namespace: biological_process
def: "The specification and formation of the apicobasal polarity of an epithelial cell." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]
is_a: GO:0030859 ! polarized epithelial cell differentiation
is_a: GO:0035089 ! establishment of apical/basal cell polarity
is_a: GO:0045197 ! establishment or maintenance of epithelial cell apical/basal polarity
is_a: GO:0090162 ! establishment of epithelial cell polarity

[Term]
id: GO:0045199
name: maintenance of epithelial cell apical/basal polarity
namespace: biological_process
def: "The maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf]
is_a: GO:0035090 ! maintenance of apical/basal cell polarity
is_a: GO:0045197 ! establishment or maintenance of epithelial cell apical/basal polarity

[Term]
id: GO:0045200
name: establishment of neuroblast polarity
namespace: biological_process
alt_id: GO:0043340
alt_id: GO:0043343
def: "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu]
synonym: "establishment of neuroblast cell polarity" EXACT []
is_a: GO:0030010 ! establishment of cell polarity
is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity

[Term]
id: GO:0045201
name: maintenance of neuroblast polarity
namespace: biological_process
alt_id: GO:0043341
alt_id: GO:0043344
def: "The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu]
synonym: "maintenance of neuroblast cell polarity" EXACT []
is_a: GO:0030011 ! maintenance of cell polarity
is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity

[Term]
id: GO:0045202
name: synapse
namespace: cellular_component
def: "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
synonym: "synaptic junction" EXACT []
xref: NIF_Subcellular:sao914572699
xref: Wikipedia:Chemical_synapse
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0045203
name: integral to cell outer membrane
namespace: cellular_component
def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the external outer membrane of the cell. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "integral to external membrane" RELATED []
synonym: "integral to outer membrane" RELATED []
is_a: GO:0016021 ! integral to membrane
is_a: GO:0031230 ! intrinsic to cell outer membrane

[Term]
id: GO:0045204
name: MAPK export from nucleus
namespace: biological_process
def: "The directed movement of a MAP kinase from the nucleus to the cytoplasm." [GOC:ebc]
synonym: "cytoplasmic translocation of MAP kinase" EXACT []
synonym: "cytoplasmic translocation of mitogen-activated protein kinase" EXACT []
synonym: "MAPK export from cell nucleus" EXACT []
synonym: "MAPK export out of nucleus" EXACT []
synonym: "MAPK transport from nucleus to cytoplasm" EXACT []
synonym: "MAPK-nucleus export" EXACT []
is_a: GO:0006611 ! protein export from nucleus

[Term]
id: GO:0045205
name: MAPK transporter activity
namespace: molecular_function
def: "OBSOLETE. Enables the directed movement of MAP kinase into, out of, within or between cells." [GOC:ebc, GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because we do not know what it was intended to represent when it was created.
is_obsolete: true

[Term]
id: GO:0045206
name: MAPK phosphatase transporter activity
namespace: molecular_function
alt_id: GO:0045207
def: "OBSOLETE. Enables the directed movement of MAPK phosphatase into, out of, within or between cells." [GOC:ebc, GOC:mtg_transport, ISBN:0815340729]
comment: This term was made obsolete because we do not know what it was intended to represent when it was created.
synonym: "leptomycin B-sensitive MAPK phosphatase transporter activity" NARROW []
synonym: "leptomycin B-sensitive MKP shuttle" NARROW []
synonym: "MKP shuttle" NARROW []
is_obsolete: true

[Term]
id: GO:0045208
name: MAPK phosphatase export from nucleus
namespace: biological_process
def: "The directed movement of a MAPK phosphatase from the nucleus to the cytoplasm." [GOC:ebc]
synonym: "MAPK phosphatase export from cell nucleus" EXACT []
synonym: "MAPK phosphatase export out of nucleus" EXACT []
synonym: "MAPK phosphatase transport from nucleus to cytoplasm" EXACT []
synonym: "MAPK phosphatase-nucleus export" EXACT []
is_a: GO:0006611 ! protein export from nucleus

[Term]
id: GO:0045209
name: MAPK phosphatase export from nucleus, leptomycin B sensitive
namespace: biological_process
def: "Leptomycin B-sensitive movement of a MAPK phosphatase from the nucleus to the cytoplasm." [GOC:ebc]
synonym: "leptomycin B-sensitive MAPK phosphatase export out of nucleus" EXACT []
synonym: "leptomycin B-sensitive MAPK phosphatase transport from nucleus to cytoplasm" EXACT []
synonym: "leptomycin B-sensitive MAPK phosphatase-nucleus export" EXACT []
synonym: "MAPK phosphatase export from cell nucleus, leptomycin B sensitive" EXACT []
synonym: "MAPK phosphatase export out of nucleus, leptomycin B sensitive" EXACT []
synonym: "MAPK phosphatase transport from nucleus to cytoplasm, leptomycin B sensitive" EXACT []
synonym: "MAPK phosphatase-nucleus export, leptomycin B sensitive" EXACT []
is_a: GO:0045208 ! MAPK phosphatase export from nucleus

[Term]
id: GO:0045210
name: FasL biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fas ligand (FasL or CD95L), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines." [http://www.copewithcytokines.de/]
synonym: "APT1LG1 biosynthetic process" EXACT [GOC:add]
synonym: "CD178 biosynthetic process" EXACT [GOC:add]
synonym: "CD95L biosynthesis" EXACT [GOC:add]
synonym: "CD95L biosynthetic process" EXACT [GOC:add]
synonym: "fas ligand biosynthetic process" EXACT [GOC:add, PRO:000000095]
synonym: "Fas-L biosynthetic process" EXACT [GOC:add]
synonym: "FasL anabolism" EXACT []
synonym: "FasL biosynthesis" EXACT []
synonym: "FasL formation" EXACT []
synonym: "FasL synthesis" EXACT []
synonym: "FASLG biosynthetic process" EXACT [GOC:add]
is_a: GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0045211
name: postsynaptic membrane
namespace: cellular_component
def: "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "post-synaptic membrane" EXACT []
is_a: GO:0016020 ! membrane
is_a: GO:0044456 ! synapse part

[Term]
id: GO:0045212
name: neurotransmitter receptor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of neurotransmitter receptors." [GOC:ai]
synonym: "neurotransmitter receptor anabolism" EXACT []
synonym: "neurotransmitter receptor biosynthesis" EXACT []
synonym: "neurotransmitter receptor formation" EXACT []
synonym: "neurotransmitter receptor synthesis" EXACT []
is_a: GO:0032800 ! receptor biosynthetic process
is_a: GO:0045213 ! neurotransmitter receptor metabolic process

[Term]
id: GO:0045213
name: neurotransmitter receptor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving neurotransmitter receptors." [GOC:go_curators]
synonym: "neurotransmitter receptor metabolism" EXACT []
is_a: GO:0043112 ! receptor metabolic process
relationship: part_of GO:0007268 ! synaptic transmission

[Term]
id: GO:0045214
name: sarcomere organization
namespace: biological_process
alt_id: GO:0006938
def: "The myofibril assembly process by which the muscle actomyosin is organized into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]
synonym: "sarcomere alignment" EXACT []
synonym: "sarcomere organisation" EXACT [GOC:curators]
is_a: GO:0031032 ! actomyosin structure organization
relationship: part_of GO:0030239 ! myofibril assembly

[Term]
id: GO:0045216
name: cell-cell junction organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "cell-cell junction assembly and maintenance" EXACT []
synonym: "cell-cell junction biogenesis" RELATED []
synonym: "intercellular junction assembly and maintenance" EXACT []
is_a: GO:0034330 ! cell junction organization

[Term]
id: GO:0045217
name: cell-cell junction maintenance
namespace: biological_process
def: "The maintenance of junctions between cells." [GOC:ai]
synonym: "intercellular junction maintenance" EXACT []
is_a: GO:0034331 ! cell junction maintenance
is_a: GO:0045216 ! cell-cell junction organization

[Term]
id: GO:0045218
name: zonula adherens maintenance
namespace: biological_process
def: "Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells." [GOC:bf]
is_a: GO:0045217 ! cell-cell junction maintenance

[Term]
id: GO:0045219
name: regulation of FasL biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators]
synonym: "regulation of FasL anabolism" EXACT []
synonym: "regulation of FasL biosynthesis" EXACT []
synonym: "regulation of FasL formation" EXACT []
synonym: "regulation of FasL synthesis" EXACT []
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
relationship: regulates GO:0045210 ! FasL biosynthetic process

[Term]
id: GO:0045220
name: positive regulation of FasL biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators]
synonym: "activation of FasL biosynthetic process" NARROW []
synonym: "positive regulation of FasL anabolism" EXACT []
synonym: "positive regulation of FasL biosynthesis" EXACT []
synonym: "positive regulation of FasL formation" EXACT []
synonym: "positive regulation of FasL synthesis" EXACT []
synonym: "stimulation of FasL biosynthetic process" NARROW []
synonym: "up regulation of FasL biosynthetic process" EXACT []
synonym: "up-regulation of FasL biosynthetic process" EXACT []
synonym: "upregulation of FasL biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0045219 ! regulation of FasL biosynthetic process
relationship: positively_regulates GO:0045210 ! FasL biosynthetic process

[Term]
id: GO:0045221
name: negative regulation of FasL biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators]
synonym: "down regulation of FasL biosynthetic process" EXACT []
synonym: "down-regulation of FasL biosynthetic process" EXACT []
synonym: "downregulation of FasL biosynthetic process" EXACT []
synonym: "inhibition of FasL biosynthetic process" NARROW []
synonym: "negative regulation of FasL anabolism" EXACT []
synonym: "negative regulation of FasL biosynthesis" EXACT []
synonym: "negative regulation of FasL formation" EXACT []
synonym: "negative regulation of FasL synthesis" EXACT []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0045219 ! regulation of FasL biosynthetic process
relationship: negatively_regulates GO:0045210 ! FasL biosynthetic process

[Term]
id: GO:0045222
name: CD4 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "CD4 anabolism" EXACT []
synonym: "CD4 biosynthesis" EXACT []
synonym: "CD4 formation" EXACT []
synonym: "CD4 synthesis" EXACT []
is_a: GO:0009101 ! glycoprotein biosynthetic process

[Term]
id: GO:0045223
name: regulation of CD4 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]
synonym: "regulation of CD4 anabolism" EXACT []
synonym: "regulation of CD4 biosynthesis" EXACT []
synonym: "regulation of CD4 formation" EXACT []
synonym: "regulation of CD4 synthesis" EXACT []
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
relationship: regulates GO:0045222 ! CD4 biosynthetic process

[Term]
id: GO:0045224
name: positive regulation of CD4 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]
synonym: "activation of CD4 biosynthetic process" NARROW []
synonym: "positive regulation of CD4 anabolism" EXACT []
synonym: "positive regulation of CD4 biosynthesis" EXACT []
synonym: "positive regulation of CD4 formation" EXACT []
synonym: "positive regulation of CD4 synthesis" EXACT []
synonym: "stimulation of CD4 biosynthetic process" NARROW []
synonym: "up regulation of CD4 biosynthetic process" EXACT []
synonym: "up-regulation of CD4 biosynthetic process" EXACT []
synonym: "upregulation of CD4 biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0045223 ! regulation of CD4 biosynthetic process
relationship: positively_regulates GO:0045222 ! CD4 biosynthetic process

[Term]
id: GO:0045225
name: negative regulation of CD4 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]
synonym: "down regulation of CD4 biosynthetic process" EXACT []
synonym: "down-regulation of CD4 biosynthetic process" EXACT []
synonym: "downregulation of CD4 biosynthetic process" EXACT []
synonym: "inhibition of CD4 biosynthetic process" NARROW []
synonym: "negative regulation of CD4 anabolism" EXACT []
synonym: "negative regulation of CD4 biosynthesis" EXACT []
synonym: "negative regulation of CD4 formation" EXACT []
synonym: "negative regulation of CD4 synthesis" EXACT []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0045223 ! regulation of CD4 biosynthetic process
relationship: negatively_regulates GO:0045222 ! CD4 biosynthetic process

[Term]
id: GO:0045226
name: extracellular polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators]
subset: gosubset_prok
synonym: "extracellular polysaccharide anabolism" EXACT []
synonym: "extracellular polysaccharide biosynthesis" EXACT []
synonym: "extracellular polysaccharide formation" EXACT []
synonym: "extracellular polysaccharide synthesis" EXACT []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0046379 ! extracellular polysaccharide metabolic process

[Term]
id: GO:0045227
name: capsule polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "capsular polysaccharide biosynthesis" EXACT []
synonym: "capsular polysaccharide biosynthetic process" EXACT []
synonym: "capsule polysaccharide anabolism" EXACT []
synonym: "capsule polysaccharide biosynthesis" EXACT []
synonym: "capsule polysaccharide formation" EXACT []
synonym: "capsule polysaccharide synthesis" EXACT []
is_a: GO:0045226 ! extracellular polysaccharide biosynthetic process
is_a: GO:0045230 ! capsule organization

[Term]
id: GO:0045228
name: slime layer polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "slime layer polysaccharide anabolism" EXACT []
synonym: "slime layer polysaccharide biosynthesis" EXACT []
synonym: "slime layer polysaccharide formation" EXACT []
synonym: "slime layer polysaccharide synthesis" EXACT []
is_a: GO:0045226 ! extracellular polysaccharide biosynthetic process
is_a: GO:0045231 ! slime layer organization

[Term]
id: GO:0045229
name: external encapsulating structure organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "external encapsulating structure organisation" EXACT [GOC:curators]
synonym: "external encapsulating structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0045230
name: capsule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "capsule organisation" EXACT [GOC:curators]
synonym: "capsule organization and biogenesis" RELATED []
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0045231
name: slime layer organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a slime layer. A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "slime layer organisation" EXACT [GOC:curators]
synonym: "slime layer organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0045232
name: S-layer organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an S-layer enveloping the cell. The S-layer is a crystalline protein layer surrounding some bacteria." [GOC:ai]
synonym: "S-layer organisation" EXACT [GOC:curators]
synonym: "S-layer organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0045233
name: natural killer cell receptor activity
namespace: molecular_function
def: "A receptor found on the surface of natural killer cells which binds Class I MHC antigens and is required for activation of NK activity. It belongs to the Ly49i family." [GOC:ebc]
synonym: "Ly49i" NARROW []
synonym: "NK cell receptor activity" EXACT []
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0045234
name: protein palmitoleylation
namespace: biological_process
def: "The covalent or non-covalent attachment of a palmitoleyl moiety to a protein." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006497 ! protein amino acid lipidation
is_a: GO:0043543 ! protein amino acid acylation

[Term]
id: GO:0045235
name: protein amino acid palmitoleylation
namespace: biological_process
def: "The covalent or non-covalent attachment of a palmitoleyl moiety to a protein amino acid." [GOC:ai]
subset: gosubset_prok
is_a: GO:0045234 ! protein palmitoleylation

[Term]
id: GO:0045236
name: CXCR chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a chemokine receptor in the CXCR family." [GOC:ceb, PMID:11910892]
synonym: "alpha chemokine receptor binding" EXACT []
synonym: "alpha chemokine receptor ligand" NARROW []
synonym: "C-X-C chemokine receptor ligand" NARROW []
synonym: "CXC chemokine receptor ligand" NARROW []
is_a: GO:0042379 ! chemokine receptor binding

[Term]
id: GO:0045237
name: CXCR1 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the CXCR1 chemokine receptor." [GOC:ceb, PMID:11910892]
synonym: "CXCR1 chemokine receptor ligand" NARROW []
is_a: GO:0005153 ! interleukin-8 receptor binding

[Term]
id: GO:0045238
name: CXCR2 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the CXCR2 chemokine receptor." [GOC:ceb, PMID:11910892]
synonym: "CXCR2 chemokine receptor ligand" NARROW []
is_a: GO:0005153 ! interleukin-8 receptor binding

[Term]
id: GO:0045239
name: tricarboxylic acid cycle enzyme complex
namespace: cellular_component
def: "Any of the heteromeric enzymes that act in the TCA cycle." [GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "TCA cycle enzyme complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045240
name: dihydrolipoyl dehydrogenase complex
namespace: cellular_component
def: "A protein complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah]
subset: gosubset_prok
synonym: "2-oxoglutarate dehydrogenase complex" EXACT []
synonym: "alpha-ketoglutarate dehydrogenase complex" EXACT []
is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex

[Term]
id: GO:0045241
name: cytosolic alpha-ketoglutarate dehydrogenase complex
namespace: cellular_component
def: "Cytosolic complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "2-oxoglutarate dehydrogenase complex" BROAD []
is_a: GO:0045240 ! dihydrolipoyl dehydrogenase complex
is_a: GO:0045246 ! cytosolic tricarboxylic acid cycle enzyme complex

[Term]
id: GO:0045242
name: isocitrate dehydrogenase complex (NAD+)
namespace: cellular_component
def: "Complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah]
subset: gosubset_prok
is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex

[Term]
id: GO:0045243
name: cytosolic isocitrate dehydrogenase complex (NAD+)
namespace: cellular_component
def: "Cytosolic complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "isocitrate dehydrogenase complex (NAD+)" BROAD []
is_a: GO:0045242 ! isocitrate dehydrogenase complex (NAD+)
is_a: GO:0045246 ! cytosolic tricarboxylic acid cycle enzyme complex

[Term]
id: GO:0045244
name: succinate-CoA ligase complex (GDP-forming)
namespace: cellular_component
alt_id: GO:0008325
alt_id: GO:0045245
def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP." [EC:6.2.1.4, GOC:jl]
synonym: "succinyl-CoA synthetase, GDP-forming" EXACT [CORUM:392]
is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex
is_a: GO:0042709 ! succinate-CoA ligase complex

[Term]
id: GO:0045246
name: cytosolic tricarboxylic acid cycle enzyme complex
namespace: cellular_component
def: "Any of the heteromeric enzymes, located in the cytosol, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "TCA cycle enzyme complex" BROAD []
synonym: "tricarboxylic acid cycle enzyme complex " BROAD []
is_a: GO:0044445 ! cytosolic part
is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex

[Term]
id: GO:0045247
name: cytosolic electron transfer flavoprotein complex
namespace: cellular_component
def: "A protein complex located in the cytosol containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0044445 ! cytosolic part
is_a: GO:0045251 ! electron transfer flavoprotein complex

[Term]
id: GO:0045248
name: cytosolic oxoglutarate dehydrogenase complex
namespace: cellular_component
def: "A cytosolic complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [GOC:mtg_sensu, PMID:10848975]
comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'.
subset: gosubset_prok
is_a: GO:0044445 ! cytosolic part
is_a: GO:0045252 ! oxoglutarate dehydrogenase complex

[Term]
id: GO:0045249
name: cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex
namespace: cellular_component
def: "A cytosolic complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [GOC:mtg_sensu, PMID:9395502]
comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'.
subset: gosubset_prok
is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex

[Term]
id: GO:0045250
name: cytosolic pyruvate dehydrogenase complex
namespace: cellular_component
def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order." [GOC:mtg_sensu, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
subset: gosubset_prok
synonym: "pyruvate dehydrogenase complex (lipoamide)" RELATED []
is_a: GO:0045254 ! pyruvate dehydrogenase complex

[Term]
id: GO:0045251
name: electron transfer flavoprotein complex
namespace: cellular_component
def: "A protein complex containing flavin adenine dinucleotide (FAD) and acyl-CoA dehydrogenase, which form a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045252
name: oxoglutarate dehydrogenase complex
namespace: cellular_component
def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [MetaCyc:CPLX66-42, PMID:10848975]
comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'.
subset: goslim_pir
subset: gosubset_prok
synonym: "dihydrolipoamide S-succinyltransferase complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0045253
name: pyruvate dehydrogenase (lipoamide) phosphatase complex
namespace: cellular_component
def: "A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [PMID:9395502]
comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'.
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045254
name: pyruvate dehydrogenase complex
namespace: cellular_component
alt_id: GO:0009364
def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3)." [ISBN:0716720094]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'.
subset: goslim_pir
subset: gosubset_prok
synonym: "dihydrolipoyl dehydrogenase complex" BROAD []
synonym: "pyruvate dehydrogenase complex (lipoamide)" EXACT []
xref: Wikipedia:Pyruvate_dehydrogenase_complex
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045257
name: succinate dehydrogenase complex (ubiquinone)
namespace: cellular_component
def: "The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0045281 ! succinate dehydrogenase complex

[Term]
id: GO:0045258
name: plasma membrane succinate dehydrogenase complex (ubiquinone)
namespace: cellular_component
def: "The enzyme, located in the plasma membrane, that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, GOC:mtg_sensu, ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0045257 ! succinate dehydrogenase complex (ubiquinone)
is_a: GO:0045282 ! plasma membrane succinate dehydrogenase complex

[Term]
id: GO:0045259
name: proton-transporting ATP synthase complex
namespace: cellular_component
alt_id: GO:0045255
def: "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." [EC:3.6.3.14, ISBN:0198547684, ISBN:0716743663]
subset: gosubset_prok
synonym: "hydrogen-translocating F-type ATPase complex" EXACT []
synonym: "hydrogen-transporting ATP synthase complex" EXACT []
synonym: "proton-transporting F-type ATPase complex" RELATED []
is_a: GO:0016469 ! proton-transporting two-sector ATPase complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0045260
name: plasma membrane proton-transporting ATP synthase complex
namespace: cellular_component
alt_id: GO:0045256
def: "A proton-transporting ATP synthase complex found in the plasma membrane. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu, ISBN:0198547684]
subset: gosubset_prok
synonym: "hydrogen-translocating F-type ATPase complex " BROAD []
synonym: "hydrogen-transporting ATP synthase" EXACT []
synonym: "plasma membrane hydrogen-translocating F-type ATPase complex" EXACT []
synonym: "proton-transporting ATP synthase complex" BROAD []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045259 ! proton-transporting ATP synthase complex

[Term]
id: GO:0045261
name: proton-transporting ATP synthase complex, catalytic core F(1)
namespace: cellular_component
def: "The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, F1 sector" EXACT []
is_a: GO:0033178 ! proton-transporting two-sector ATPase complex, catalytic domain
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0045259 ! proton-transporting ATP synthase complex

[Term]
id: GO:0045262
name: plasma membrane proton-transporting ATP synthase complex, catalytic core F(1)
namespace: cellular_component
def: "The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu, PMID:10838056]
comment: See also the cellular component term 'plasma membrane ; GO:0005886'.
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD []
synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" BROAD []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)
relationship: part_of GO:0045260 ! plasma membrane proton-transporting ATP synthase complex

[Term]
id: GO:0045263
name: proton-transporting ATP synthase complex, coupling factor F(o)
namespace: cellular_component
def: "All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins." [PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase complex, coupling factor F(o)" EXACT [GOC:mah]
synonym: "hydrogen-transporting ATP synthase, coupling factor CF(0)" NARROW []
synonym: "hydrogen-transporting ATP synthase, F0 sector" EXACT []
synonym: "proton-transporting ATP synthase complex, coupling factor F(0)" EXACT []
is_a: GO:0033177 ! proton-transporting two-sector ATPase complex, proton-transporting domain
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0045259 ! proton-transporting ATP synthase complex

[Term]
id: GO:0045264
name: plasma membrane proton-transporting ATP synthase complex, coupling factor F(o)
namespace: cellular_component
def: "All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins." [GOC:mah, GOC:mtg_sensu, PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, F0 sector" BROAD []
synonym: "proton-transporting ATP synthase complex, coupling factor F(0)" BROAD []
synonym: "proton-transporting ATP synthase complex, coupling factor F(o)" BROAD []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o)
relationship: part_of GO:0045260 ! plasma membrane proton-transporting ATP synthase complex

[Term]
id: GO:0045265
name: proton-transporting ATP synthase, stator stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core." [PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, stator stalk" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o)

[Term]
id: GO:0045266
name: plasma membrane proton-transporting ATP synthase, stator stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, stator stalk" BROAD []
synonym: "proton-transporting ATP synthase, stator stalk" BROAD []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk
relationship: part_of GO:0045264 ! plasma membrane proton-transporting ATP synthase complex, coupling factor F(o)

[Term]
id: GO:0045267
name: proton-transporting ATP synthase, catalytic core
namespace: cellular_component
def: "The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, catalytic core" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)

[Term]
id: GO:0045268
name: plasma membrane proton-transporting ATP synthase, catalytic core
namespace: cellular_component
def: "The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, catalytic core" BROAD []
synonym: "proton-transporting ATP synthase, catalytic core" BROAD []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045267 ! proton-transporting ATP synthase, catalytic core
relationship: part_of GO:0045262 ! plasma membrane proton-transporting ATP synthase complex, catalytic core F(1)

[Term]
id: GO:0045269
name: proton-transporting ATP synthase, central stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis." [PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, central stalk" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1)

[Term]
id: GO:0045270
name: plasma membrane proton-transporting ATP synthase, central stalk
namespace: cellular_component
def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056]
subset: gosubset_prok
synonym: "hydrogen-transporting ATP synthase, central stalk" BROAD []
synonym: "proton-transporting ATP synthase, central stalk" BROAD []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045269 ! proton-transporting ATP synthase, central stalk
relationship: part_of GO:0045262 ! plasma membrane proton-transporting ATP synthase complex, catalytic core F(1)

[Term]
id: GO:0045271
name: respiratory chain complex I
namespace: cellular_component
alt_id: GO:0045279
def: "Respiratory chain complex I is an enzyme of the respiratory chain. It consists of at least 34 polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex." [GOC:jic, ISBN:0716749556]
comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (ubiquinone) activity ; GO:0008137'.
subset: gosubset_prok
synonym: "electron transport complex I" RELATED []
synonym: "NADH dehydrogenase (ubiquinone) complex" EXACT []
synonym: "NADH dehydrogenase complex (ubiquinone)" EXACT []
synonym: "NADH-Q oxidoreductase complex" EXACT []
is_a: GO:0030964 ! NADH dehydrogenase complex
relationship: part_of GO:0070469 ! respiratory chain

[Term]
id: GO:0045272
name: plasma membrane respiratory chain complex I
namespace: cellular_component
def: "A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, ISBN:0198547684]
subset: gosubset_prok
synonym: "NADH dehydrogenase (ubiquinone) complex" BROAD []
synonym: "respiratory chain complex I" BROAD []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045271 ! respiratory chain complex I
relationship: part_of GO:0070470 ! plasma membrane respiratory chain

[Term]
id: GO:0045273
name: respiratory chain complex II
namespace: cellular_component
def: "A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [ISBN:0198547684]
subset: goslim_pir
subset: gosubset_prok
synonym: "electron transport complex II" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0070469 ! respiratory chain

[Term]
id: GO:0045274
name: plasma membrane respiratory chain complex II
namespace: cellular_component
def: "A part of the respiratory chain located in the plasma membrane, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, ISBN:0198547684]
subset: gosubset_prok
synonym: "respiratory chain complex II" BROAD []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045273 ! respiratory chain complex II
relationship: part_of GO:0070470 ! plasma membrane respiratory chain

[Term]
id: GO:0045275
name: respiratory chain complex III
namespace: cellular_component
alt_id: GO:0032842
alt_id: GO:0045285
def: "A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [PMID:16228398, PMID:16352458, PMID:17200733]
subset: goslim_pir
subset: gosubset_prok
synonym: "complex III" EXACT []
synonym: "cytochrome bc(1) complex" EXACT []
synonym: "cytochrome bc1 complex" EXACT []
synonym: "electron transport complex III" RELATED []
synonym: "ubiquinol-cytochrome c oxidoreductase complex" EXACT []
synonym: "ubiquinol-cytochrome-c reductase complex" EXACT []
xref: Wikipedia:Coenzyme_Q_-_cytochrome_c_reductase
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0070469 ! respiratory chain

[Term]
id: GO:0045276
name: plasma membrane respiratory chain complex III
namespace: cellular_component
alt_id: GO:0045286
def: "A part of the respiratory chain located in the plasma membrane, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, ISBN:0198547684]
subset: gosubset_prok
synonym: "plasma membrane ubiquinol-cytochrome-c reductase complex" EXACT []
synonym: "respiratory chain complex III" BROAD []
synonym: "ubiquinol-cytochrome c oxidoreductase complex" BROAD []
synonym: "ubiquinol-cytochrome-c reductase complex" BROAD []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045275 ! respiratory chain complex III
relationship: part_of GO:0070470 ! plasma membrane respiratory chain

[Term]
id: GO:0045277
name: respiratory chain complex IV
namespace: cellular_component
alt_id: GO:0045287
def: "A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [ISBN:0198547684]
subset: goslim_pir
subset: gosubset_prok
synonym: "cytochrome c oxidase complex" EXACT []
synonym: "electron transport complex IV" RELATED []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0070469 ! respiratory chain

[Term]
id: GO:0045278
name: plasma membrane respiratory chain complex IV
namespace: cellular_component
alt_id: GO:0045288
def: "A part of the respiratory chain located in the plasma membrane, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). Examples of this component are found in Bacterial species." [GOC:mtg_sensu, ISBN:0198547684]
subset: gosubset_prok
synonym: "cytochrome c oxidase complex" BROAD []
synonym: "respiratory chain complex IV" BROAD []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045277 ! respiratory chain complex IV
relationship: part_of GO:0070470 ! plasma membrane respiratory chain

[Term]
id: GO:0045281
name: succinate dehydrogenase complex
namespace: cellular_component
def: "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones." [GOC:kd, InterPro:IPR000701]
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0045273 ! respiratory chain complex II

[Term]
id: GO:0045282
name: plasma membrane succinate dehydrogenase complex
namespace: cellular_component
def: "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. Examples of this component are found in Bacterial species." [GOC:kd, GOC:mtg_sensu, InterPro:IPR000701]
subset: gosubset_prok
synonym: "succinate dehydrogenase complex" BROAD []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045281 ! succinate dehydrogenase complex
relationship: part_of GO:0045274 ! plasma membrane respiratory chain complex II

[Term]
id: GO:0045283
name: fumarate reductase complex
namespace: cellular_component
def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone))." [InterPro:IPR003418, InterPro:IPR004224]
comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'.
subset: gosubset_prok
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0045273 ! respiratory chain complex II

[Term]
id: GO:0045284
name: plasma membrane fumarate reductase complex
namespace: cellular_component
def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR00224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). Examples of this component are found in Bacterial species." [GOC:mtg_sensu, InterPro:IPR003418, InterPro:IPR004224]
comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'.
subset: gosubset_prok
synonym: "fumarate reductase complex" BROAD []
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0045283 ! fumarate reductase complex
relationship: part_of GO:0045274 ! plasma membrane respiratory chain complex II

[Term]
id: GO:0045289
name: luciferin monooxygenase activity
namespace: molecular_function
def: "Catalysis of the oxidation of luciferin. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation." [GOC:bf]
synonym: "luciferase activity" EXACT []
synonym: "luciferase monooxygenase activity" RELATED []
xref: MetaCyc:1.13.12.7-RXN
xref: MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN
xref: MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN
xref: MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0045290
name: D-arabinose 1-dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+. Also acts on L-galactose, 6-deoxy- and 3,6-dideoxy-L-galactose." [EC:1.1.1.117]
synonym: "D-arabinose:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.117]
xref: EC:1.1.1.117
xref: MetaCyc:1.1.1.117-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0045291
name: nuclear mRNA trans splicing, SL addition
namespace: biological_process
def: "The joining together of two independently transcribed RNAs, where the one that provides the 5' portion of the final mRNA is from a splice leader RNA (SL-RNA). The SL-RNA, or mini-exon donor sequence, is added to the 5'-end of the acceptor RNA molecule which provides the mRNA body." [GOC:krc, ISBN:0879695897, PMID:2675423]
synonym: "nuclear mRNA trans splicing, spliced leader addition" EXACT []
is_a: GO:0000365 ! nuclear mRNA trans splicing, via spliceosome

[Term]
id: GO:0045292
name: nuclear mRNA cis splicing, via spliceosome
namespace: biological_process
def: "The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, http://calspace.ucsd.edu/origins/Glossary/C.htm, ISBN:0879695897]
synonym: "nuclear mRNA cis splicing, via U2-type spliceosome" NARROW []
is_a: GO:0000398 ! nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0045293
name: mRNA editing complex
namespace: cellular_component
def: "A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes." [http://www.ejbiotechnology.info/content/vol1/issue1/full/4/, PMID:11564867, PMID:12139607]
subset: goslim_pir
synonym: "editosome" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0045294
name: alpha-catenin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the alpha subunit of the catenin complex." [GOC:bf]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045295
name: gamma-catenin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the gamma subunit of the catenin complex." [GOC:bf]
synonym: "plakoglobin binding" EXACT [GOC:BHF]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045296
name: cadherin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]
is_a: GO:0050839 ! cell adhesion molecule binding

[Term]
id: GO:0045297
name: post-mating behavior
namespace: biological_process
def: "The specific actions or reactions of an organism following mating." [GOC:bf]
synonym: "post-mating behaviour" EXACT []
is_a: GO:0019098 ! reproductive behavior

[Term]
id: GO:0045298
name: tubulin complex
namespace: cellular_component
def: "A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly." [http://cancerweb.ncl.ac.uk/, ISBN:0716731363]
is_a: GO:0043234 ! protein complex
is_a: GO:0044430 ! cytoskeletal part

[Term]
id: GO:0045299
name: otolith mineralization
namespace: biological_process
def: "The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear." [GOC:dsf, PMID:15581873]
is_a: GO:0031214 ! biomineral formation
relationship: part_of GO:0048840 ! otolith development

[Term]
id: GO:0045300
name: acyl-[acyl-carrier-protein] desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin." [EC:1.14.19.2]
comment: Note that this function was formerly EC:1.14.99.6.
subset: gosubset_prok
synonym: "acyl-[acyl-carrier protein] desaturase activity" EXACT []
synonym: "acyl-acyl-carrier-protein desaturase activity" EXACT [EC:1.14.19.2]
synonym: "acyl-acyl-carrier-protein, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.2]
synonym: "stearyl acyl carrier protein desaturase activity" EXACT [EC:1.14.19.2]
synonym: "stearyl-ACP desaturase activity" EXACT [EC:1.14.19.2]
xref: EC:1.14.19.2
xref: MetaCyc:1.14.19.2-RXN
xref: MetaCyc:PWY-5147
is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

[Term]
id: GO:0045301
name: tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin." [GOC:mlg, PMID:8253666]
subset: gosubset_prok
synonym: "2-methylthio-cis-ribozeatin hydroxylase activity" EXACT []
synonym: "tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyladenosine)-hydroxylase activity" EXACT []
synonym: "tRNA-(ms2io6A)-hydroxylase activity" EXACT []
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0045302
name: choloylglycine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine." [EC:3.5.1.24]
subset: gosubset_prok
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase activity" EXACT [EC:3.5.1.24]
synonym: "bile salt hydrolase activity" EXACT [EC:3.5.1.24]
synonym: "choloyltaurine hydrolase activity" EXACT [EC:3.5.1.24]
synonym: "glycocholase activity" EXACT [EC:3.5.1.24]
xref: EC:3.5.1.24
xref: MetaCyc:CHOLOYLGLYCINE-HYDROLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0045303
name: diaminobutyrate-2-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2,4-diaminobutyrate + 2-oxoglutarate = L-glutamate + L-aspartic 4-semialdehyde." [EC:2.6.1.76]
subset: gosubset_prok
synonym: "2,4-diaminobutyrate 4-aminotransferase activity" EXACT [EC:2.6.1.76]
synonym: "DAB aminotransferase activity" EXACT [EC:2.6.1.76]
synonym: "DABA aminotransferase activity" EXACT [EC:2.6.1.76]
synonym: "diaminibutyric acid aminotransferase activity" EXACT [EC:2.6.1.76]
synonym: "diaminobutyrate transaminase activity" EXACT [EC:2.6.1.76]
synonym: "diaminobutyrate--2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.76]
synonym: "EctB" RELATED [EC:2.6.1.76]
synonym: "L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76]
synonym: "L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76]
synonym: "L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase activity" EXACT [EC:2.6.1.76]
xref: EC:2.6.1.76
xref: MetaCyc:R101-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0045304
name: regulation of establishment of competence for transformation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process by which a cell becomes able to take up and incorporate extracellular DNA into its genome." [GOC:mlg]
subset: gosubset_prok
synonym: "regulator of establishment of competence for transformation activity" RELATED []
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0032104 ! regulation of response to extracellular stimulus
is_a: GO:0043900 ! regulation of multi-organism process
relationship: regulates GO:0030420 ! establishment of competence for transformation

[Term]
id: GO:0045305
name: regulator of establishment of competence for transformation activity
namespace: molecular_function
def: "OBSOLETE. Functions to either promote or inhibit the establishment of competence for transformation." [GOC:mlg]
comment: This term was made obsolete because it does not represent a true function.
is_obsolete: true
replaced_by: GO:0045304

[Term]
id: GO:0045306
name: inhibitor of the establishment of competence for transformation activity
namespace: molecular_function
def: "OBSOLETE. Inhibits the establishment of competence for transformation." [GOC:mlg]
comment: This term was made obsolete because it does not represent a true function.
is_obsolete: true
replaced_by: GO:0045808

[Term]
id: GO:0045307
name: activator of the establishment of competence for transformation activity
namespace: molecular_function
def: "OBSOLETE. Activates the establishment of competence for transformation." [GOC:mlg]
comment: This term was made obsolete because it does not represent a true function.
is_obsolete: true
replaced_by: GO:0045809

[Term]
id: GO:0045309
name: protein phosphorylated amino acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein." [GOC:go_curators]
synonym: "phosphoprotein amino acid binding" RELATED []
is_a: GO:0051219 ! phosphoprotein binding

[Term]
id: GO:0045310
name: phosphoserine/phosphothreonine binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with a phosphorylated serine or threonine residue within a protein." [GOC:go_curators]
comment: This term was made obsolete because it represents two functions.
is_obsolete: true
consider: GO:0050815
consider: GO:0050816

[Term]
id: GO:0045311
name: invasive growth in response to pheromones
namespace: biological_process
def: "The growth of colonies in filamentous chains of cells as a result of a pheromone stimulus." [GOC:ai, GOC:dph, GOC:mcc]
is_a: GO:0019236 ! response to pheromone
is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells

[Term]
id: GO:0045312
name: nor-spermidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators]
synonym: "nor-spermidine anabolism" EXACT []
synonym: "nor-spermidine biosynthesis" EXACT []
synonym: "nor-spermidine formation" EXACT []
synonym: "nor-spermidine synthesis" EXACT []
is_a: GO:0008295 ! spermidine biosynthetic process
is_a: GO:0046204 ! nor-spermidine metabolic process

[Term]
id: GO:0045313
name: rhabdomere membrane biogenesis
namespace: biological_process
def: "The process by which a rhabdomere membrane is synthesized, aggregates, and bonds together." [GOC:jl]
is_a: GO:0044091 ! membrane biogenesis
relationship: part_of GO:0042052 ! rhabdomere development

[Term]
id: GO:0045314
name: regulation of compound eye photoreceptor development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]
synonym: "regulation of eye photoreceptor development" BROAD []
is_a: GO:0042478 ! regulation of eye photoreceptor cell development
relationship: part_of GO:0046532 ! regulation of photoreceptor cell differentiation
relationship: regulates GO:0042051 ! compound eye photoreceptor development

[Term]
id: GO:0045315
name: positive regulation of compound eye photoreceptor development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]
synonym: "activation of eye photoreceptor development" BROAD []
synonym: "positive regulation of eye photoreceptor development" BROAD []
synonym: "stimulation of eye photoreceptor development" BROAD []
synonym: "up regulation of eye photoreceptor development" BROAD []
synonym: "up-regulation of eye photoreceptor development" BROAD []
synonym: "upregulation of eye photoreceptor development" BROAD []
is_a: GO:0042479 ! positive regulation of eye photoreceptor cell development
is_a: GO:0045314 ! regulation of compound eye photoreceptor development
relationship: positively_regulates GO:0042051 ! compound eye photoreceptor development

[Term]
id: GO:0045316
name: negative regulation of compound eye photoreceptor development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]
synonym: "down regulation of eye photoreceptor development" BROAD []
synonym: "down-regulation of eye photoreceptor development" BROAD []
synonym: "downregulation of eye photoreceptor development" BROAD []
synonym: "inhibition of eye photoreceptor development" BROAD []
synonym: "negative regulation of eye photoreceptor development" BROAD []
is_a: GO:0042480 ! negative regulation of eye photoreceptor cell development
is_a: GO:0045314 ! regulation of compound eye photoreceptor development
relationship: negatively_regulates GO:0042051 ! compound eye photoreceptor development

[Term]
id: GO:0045317
name: equator specification
namespace: biological_process
def: "The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves." [GOC:bf]
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity

[Term]
id: GO:0045319
name: SRP-independent cotranslational protein-membrane targeting, translocation
namespace: biological_process
def: "OBSOLETE. The process during cotranslational membrane targeting wherein proteins move across a membrane. This process is independent of SRP and signal recognition." [GOC:ai]
comment: This term was made obsolete because there is no evidence for the existence of this process.
synonym: "SRP-independent cotranslational membrane targeting, translocation" EXACT []
is_obsolete: true

[Term]
id: GO:0045320
name: chloroplast proton-transporting ATP synthase complex
namespace: cellular_component
def: "A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation." [GOC:mtg_sensu, GOC:pj, ISBN:0716743663]
synonym: "chloroplast hydrogen-translocating F-type ATPase complex" EXACT []
synonym: "chloroplast proton-transporting F-type ATPase complex" EXACT []
synonym: "hydrogen-translocating F-type ATPase complex" BROAD []
is_a: GO:0044434 ! chloroplast part
is_a: GO:0044436 ! thylakoid part
is_a: GO:0045259 ! proton-transporting ATP synthase complex
relationship: part_of GO:0009535 ! chloroplast thylakoid membrane

[Term]
id: GO:0045321
name: leukocyte activation
namespace: biological_process
def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add]
synonym: "immune cell activation" EXACT []
synonym: "leucocyte activation" EXACT []
xref: Wikipedia:Immunologic_activation
is_a: GO:0001775 ! cell activation
is_a: GO:0002376 ! immune system process

[Term]
id: GO:0045322
name: unmethylated CpG binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with unmethylated CpG motifs. Unmethylated CpG dinucleotides are often associated with gene promoters." [GOC:ai, PMID:10688657]
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0045323
name: interleukin-1 receptor complex
namespace: cellular_component
def: "A protein complex that binds interleukin-1; comprises an alpha and a beta subunit." [GOC:mah, InterPro:IPR004075]
synonym: "IL-1 receptor complex" EXACT [GOC:add]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0045324
name: late endosome to vacuole transport
namespace: biological_process
def: "The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141]
is_a: GO:0007034 ! vacuolar transport
is_a: GO:0016197 ! endosome transport

[Term]
id: GO:0045325
name: peptidyl-tryptophan hydroxylation
namespace: biological_process
def: "The posttranslational hydroxylation of peptidyl-tryptophan, to form peptidyl-L-3-hydroxytryptophan." [RESID:AA0322]
subset: gosubset_prok
xref: RESID:AA0322
is_a: GO:0018211 ! peptidyl-tryptophan modification

[Term]
id: GO:0045326
name: protein-DNA covalent cross-linking via the 3'-end to peptidyl-tyrosine
namespace: biological_process
def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-3'-DNA)-L-tyrosine." [RESID:AA0323]
subset: gosubset_prok
synonym: "DNA-protein covalent cross-linking via the 3'-end to peptidyl-tyrosine" EXACT [GOC:mah]
xref: RESID:AA0323
is_a: GO:0045327 ! protein-DNA covalent cross-linking via peptidyl-tyrosine

[Term]
id: GO:0045327
name: protein-DNA covalent cross-linking via peptidyl-tyrosine
namespace: biological_process
def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue." [GOC:jsg]
subset: gosubset_prok
synonym: "DNA-protein covalent cross-linking via peptidyl-tyrosine" EXACT [GOC:mah]
is_a: GO:0018142 ! protein-DNA covalent cross-linking
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0045328
name: cytochrome P450 4A1-heme linkage
namespace: biological_process
def: "The covalent linkage of heme to cytochrome P450 4A1 via hydroxyheme-L-glutamyl ester." [RESID:AA0324]
subset: gosubset_prok
synonym: "cytochrome P450 4A1-haem linkage" EXACT []
xref: RESID:AA0324
is_a: GO:0017003 ! protein-heme linkage
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0045329
name: carnitine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "carnitine anabolism" EXACT []
synonym: "carnitine biosynthesis" EXACT []
synonym: "carnitine formation" EXACT []
synonym: "carnitine synthesis" EXACT []
synonym: "vitamin Bt biosynthesis" EXACT []
synonym: "vitamin Bt biosynthetic process" EXACT []
xref: Reactome:448898 "Carnitine synthesis"
xref: Reactome:470015 "Carnitine synthesis"
xref: Reactome:487716 "Carnitine synthesis"
xref: Reactome:507667 "Carnitine synthesis"
xref: Reactome:517612 "Carnitine synthesis"
xref: Reactome:526462 "Carnitine synthesis"
xref: Reactome:531266 "Carnitine synthesis"
xref: Reactome:536645 "Carnitine synthesis"
xref: Reactome:542375 "Carnitine synthesis"
xref: Reactome:547718 "Carnitine synthesis"
xref: Reactome:552297 "Carnitine synthesis"
xref: Reactome:557916 "Carnitine synthesis"
xref: Reactome:568528 "Carnitine synthesis"
xref: Reactome:581740 "Carnitine synthesis"
xref: Reactome:592646 "Carnitine synthesis"
xref: Reactome:595437 "Carnitine synthesis"
xref: Reactome:597369 "Carnitine synthesis"
xref: Reactome:598162 "Carnitine synthesis"
xref: Reactome:599722 "Carnitine synthesis"
xref: Reactome:600626 "Carnitine synthesis"
xref: Reactome:602526 "Carnitine synthesis"
xref: Reactome:71262 "Carnitine synthesis"
is_a: GO:0009437 ! carnitine metabolic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process

[Term]
id: GO:0045330
name: aspartyl esterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue." [GOC:mah, SP_KW:KW-0063]
subset: gosubset_prok
is_a: GO:0016788 ! hydrolase activity, acting on ester bonds

[Term]
id: GO:0045331
name: coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: coenzyme-M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + H2 = coenzyme-M + N-(7-mercaptoheptanoyl)threonine O3-phosphate." [EC:1.12.99.2]
comment: This term was made obsolete because it represents two activities.
synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulphide hydrogenase activity" EXACT []
synonym: "heterodisulfide reductase activity" EXACT []
is_obsolete: true
replaced_by: GO:0051911
replaced_by: GO:0051912

[Term]
id: GO:0045332
name: phospholipid translocation
namespace: biological_process
def: "The translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:go_curators, ISBN:0815316194, PMID:16452632]
subset: gosubset_prok
synonym: "flippase" RELATED []
is_a: GO:0015914 ! phospholipid transport
is_a: GO:0034204 ! lipid translocation

[Term]
id: GO:0045333
name: cellular respiration
namespace: biological_process
def: "The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [ISBN:0140513590, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "oxidative metabolic process" EXACT []
synonym: "oxidative metabolism" EXACT []
synonym: "respiration" BROAD []
xref: Wikipedia:Cellular_respiration
is_a: GO:0015980 ! energy derivation by oxidation of organic compounds

[Term]
id: GO:0045334
name: clathrin-coated endocytic vesicle
namespace: cellular_component
def: "A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators]
xref: NIF_Subcellular:sao1243595998
is_a: GO:0030136 ! clathrin-coated vesicle
is_a: GO:0030139 ! endocytic vesicle

[Term]
id: GO:0045335
name: phagocytic vesicle
namespace: cellular_component
def: "A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "phagosome" EXACT []
xref: Wikipedia:Phagosome
is_a: GO:0030139 ! endocytic vesicle

[Term]
id: GO:0045336
name: clathrin-coated phagocytic vesicle
namespace: cellular_component
def: "A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "clathrin-coated phagosome" EXACT []
is_a: GO:0045334 ! clathrin-coated endocytic vesicle
is_a: GO:0045335 ! phagocytic vesicle

[Term]
id: GO:0045337
name: farnesyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of farnesyl diphosphate." [GOC:jl]
subset: gosubset_prok
synonym: "farnesyl diphosphate anabolism" EXACT []
synonym: "farnesyl diphosphate biosynthesis" EXACT []
synonym: "farnesyl diphosphate formation" EXACT []
synonym: "farnesyl diphosphate synthesis" EXACT []
xref: MetaCyc:PWY-5123
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016094 ! polyprenol biosynthetic process
is_a: GO:0045338 ! farnesyl diphosphate metabolic process

[Term]
id: GO:0045338
name: farnesyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation." [GOC:go_curators]
subset: gosubset_prok
synonym: "farnesyl diphosphate metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0016093 ! polyprenol metabolic process

[Term]
id: GO:0045339
name: farnesyl diphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of farnesyl diphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "farnesyl diphosphate breakdown" EXACT []
synonym: "farnesyl diphosphate catabolism" EXACT []
synonym: "farnesyl diphosphate degradation" EXACT []
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0016095 ! polyprenol catabolic process
is_a: GO:0045338 ! farnesyl diphosphate metabolic process

[Term]
id: GO:0045340
name: mercury ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with mercury (Hg) ions." [GOC:go_curators]
subset: gosubset_prok
synonym: "mercury binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0045341
name: MHC class I biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class I." [GOC:go_curators]
synonym: "major histocompatibility complex class I biosynthesis" EXACT []
synonym: "major histocompatibility complex class I biosynthetic process" EXACT []
synonym: "MHC class I anabolism" EXACT []
synonym: "MHC class I biosynthesis" EXACT []
synonym: "MHC class I formation" EXACT []
synonym: "MHC class I synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0045342
name: MHC class II biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II." [GOC:go_curators]
synonym: "major histocompatibility complex class II biosynthesis" EXACT []
synonym: "major histocompatibility complex class II biosynthetic process" EXACT []
synonym: "MHC class II anabolism" EXACT []
synonym: "MHC class II biosynthesis" EXACT []
synonym: "MHC class II formation" EXACT []
synonym: "MHC class II synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0045343
name: regulation of MHC class I biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators]
synonym: "regulation of major histocompatibility complex class I biosynthesis" EXACT []
synonym: "regulation of major histocompatibility complex class I biosynthetic process" EXACT []
synonym: "regulation of MHC class I anabolism" EXACT []
synonym: "regulation of MHC class I biosynthesis" EXACT []
synonym: "regulation of MHC class I formation" EXACT []
synonym: "regulation of MHC class I synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
relationship: regulates GO:0045341 ! MHC class I biosynthetic process

[Term]
id: GO:0045344
name: negative regulation of MHC class I biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators]
synonym: "down regulation of MHC class I biosynthetic process" EXACT []
synonym: "down-regulation of MHC class I biosynthetic process" EXACT []
synonym: "downregulation of MHC class I biosynthetic process" EXACT []
synonym: "inhibition of MHC class I biosynthetic process" NARROW []
synonym: "negative regulation of major histocompatibility complex class I biosynthesis" EXACT []
synonym: "negative regulation of major histocompatibility complex class I biosynthetic process" EXACT []
synonym: "negative regulation of MHC class I anabolism" EXACT []
synonym: "negative regulation of MHC class I biosynthesis" EXACT []
synonym: "negative regulation of MHC class I formation" EXACT []
synonym: "negative regulation of MHC class I synthesis" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0045343 ! regulation of MHC class I biosynthetic process
relationship: negatively_regulates GO:0045341 ! MHC class I biosynthetic process

[Term]
id: GO:0045345
name: positive regulation of MHC class I biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators]
synonym: "activation of MHC class I biosynthetic process" NARROW []
synonym: "positive regulation of major histocompatibility complex class I biosynthesis" EXACT []
synonym: "positive regulation of major histocompatibility complex class I biosynthetic process" EXACT []
synonym: "positive regulation of MHC class I anabolism" EXACT []
synonym: "positive regulation of MHC class I biosynthesis" EXACT []
synonym: "positive regulation of MHC class I formation" EXACT []
synonym: "positive regulation of MHC class I synthesis" EXACT []
synonym: "stimulation of MHC class I biosynthetic process" NARROW []
synonym: "up regulation of MHC class I biosynthetic process" EXACT []
synonym: "up-regulation of MHC class I biosynthetic process" EXACT []
synonym: "upregulation of MHC class I biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0045343 ! regulation of MHC class I biosynthetic process
relationship: positively_regulates GO:0045341 ! MHC class I biosynthetic process

[Term]
id: GO:0045346
name: regulation of MHC class II biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators]
synonym: "regulation of major histocompatibility complex class II biosynthesis" EXACT []
synonym: "regulation of major histocompatibility complex class II biosynthetic process" EXACT []
synonym: "regulation of MHC class II anabolism" EXACT []
synonym: "regulation of MHC class II biosynthesis" EXACT []
synonym: "regulation of MHC class II formation" EXACT []
synonym: "regulation of MHC class II synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
relationship: regulates GO:0045342 ! MHC class II biosynthetic process

[Term]
id: GO:0045347
name: negative regulation of MHC class II biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators]
synonym: "down regulation of MHC class II biosynthetic process" EXACT []
synonym: "down-regulation of MHC class II biosynthetic process" EXACT []
synonym: "downregulation of MHC class II biosynthetic process" EXACT []
synonym: "inhibition of MHC class II biosynthetic process" NARROW []
synonym: "negative regulation of major histocompatibility complex class II biosynthesis" EXACT []
synonym: "negative regulation of major histocompatibility complex class II biosynthetic process" EXACT []
synonym: "negative regulation of MHC class II anabolism" EXACT []
synonym: "negative regulation of MHC class II biosynthesis" EXACT []
synonym: "negative regulation of MHC class II formation" EXACT []
synonym: "negative regulation of MHC class II synthesis" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0045346 ! regulation of MHC class II biosynthetic process
relationship: negatively_regulates GO:0045342 ! MHC class II biosynthetic process

[Term]
id: GO:0045348
name: positive regulation of MHC class II biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators]
synonym: "activation of MHC class II biosynthetic process" NARROW []
synonym: "positive regulation of major histocompatibility complex class II biosynthesis" EXACT []
synonym: "positive regulation of major histocompatibility complex class II biosynthetic process" EXACT []
synonym: "positive regulation of MHC class II anabolism" EXACT []
synonym: "positive regulation of MHC class II biosynthesis" EXACT []
synonym: "positive regulation of MHC class II formation" EXACT []
synonym: "positive regulation of MHC class II synthesis" EXACT []
synonym: "stimulation of MHC class II biosynthetic process" NARROW []
synonym: "up regulation of MHC class II biosynthetic process" EXACT []
synonym: "up-regulation of MHC class II biosynthetic process" EXACT []
synonym: "upregulation of MHC class II biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0045346 ! regulation of MHC class II biosynthetic process
relationship: positively_regulates GO:0045342 ! MHC class II biosynthetic process

[Term]
id: GO:0045349
name: interferon-alpha biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators]
synonym: "IFN-alpha biosynthesis" EXACT []
synonym: "IFN-alpha biosynthetic process" EXACT []
synonym: "interferon-alpha anabolism" EXACT []
synonym: "interferon-alpha biosynthesis" EXACT []
synonym: "interferon-alpha formation" EXACT []
synonym: "interferon-alpha synthesis" EXACT []
is_a: GO:0045351 ! type I interferon biosynthetic process
relationship: part_of GO:0032607 ! interferon-alpha production

[Term]
id: GO:0045350
name: interferon-beta biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators]
synonym: "IFN-beta biosynthesis" EXACT []
synonym: "IFN-beta biosynthetic process" EXACT []
synonym: "interferon-beta anabolism" EXACT []
synonym: "interferon-beta biosynthesis" EXACT []
synonym: "interferon-beta formation" EXACT []
synonym: "interferon-beta synthesis" EXACT []
is_a: GO:0045351 ! type I interferon biosynthetic process
relationship: part_of GO:0032608 ! interferon-beta production

[Term]
id: GO:0045351
name: type I interferon biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any type I interferon. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add]
synonym: "interferon type I biosynthetic process" EXACT []
synonym: "type I interferon anabolism" EXACT []
synonym: "type I interferon biosynthesis" EXACT []
synonym: "type I interferon formation" EXACT []
synonym: "type I interferon synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032606 ! type I interferon production

[Term]
id: GO:0045352
name: interleukin-1 Type I receptor antagonist activity
namespace: molecular_function
def: "Blocks the binding of interleukin-1 to interleukin-1 Type I receptors." [GOC:ebc]
synonym: "IL-1ra type I" EXACT []
is_a: GO:0005152 ! interleukin-1 receptor antagonist activity

[Term]
id: GO:0045353
name: interleukin-1 Type II receptor antagonist activity
namespace: molecular_function
def: "Blocks the binding of interleukin-1 to interleukin-1 Type II receptors." [GOC:ebc]
synonym: "IL-1ra type II" EXACT []
is_a: GO:0005152 ! interleukin-1 receptor antagonist activity

[Term]
id: GO:0045354
name: regulation of interferon-alpha biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators]
synonym: "regulation of interferon-alpha anabolism" EXACT []
synonym: "regulation of interferon-alpha biosynthesis" EXACT []
synonym: "regulation of interferon-alpha formation" EXACT []
synonym: "regulation of interferon-alpha synthesis" EXACT []
is_a: GO:0032647 ! regulation of interferon-alpha production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0045349 ! interferon-alpha biosynthetic process

[Term]
id: GO:0045355
name: negative regulation of interferon-alpha biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators]
synonym: "down regulation of interferon-alpha biosynthetic process" EXACT []
synonym: "down-regulation of interferon-alpha biosynthetic process" EXACT []
synonym: "downregulation of interferon-alpha biosynthetic process" EXACT []
synonym: "inhibition of interferon-alpha biosynthetic process" NARROW []
synonym: "negative regulation of interferon-alpha anabolism" EXACT []
synonym: "negative regulation of interferon-alpha biosynthesis" EXACT []
synonym: "negative regulation of interferon-alpha formation" EXACT []
synonym: "negative regulation of interferon-alpha synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045354 ! regulation of interferon-alpha biosynthetic process
relationship: negatively_regulates GO:0045349 ! interferon-alpha biosynthetic process

[Term]
id: GO:0045356
name: positive regulation of interferon-alpha biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators]
synonym: "activation of interferon-alpha biosynthetic process" NARROW []
synonym: "positive regulation of interferon-alpha anabolism" EXACT []
synonym: "positive regulation of interferon-alpha biosynthesis" EXACT []
synonym: "positive regulation of interferon-alpha formation" EXACT []
synonym: "positive regulation of interferon-alpha synthesis" EXACT []
synonym: "stimulation of interferon-alpha biosynthetic process" NARROW []
synonym: "up regulation of interferon-alpha biosynthetic process" EXACT []
synonym: "up-regulation of interferon-alpha biosynthetic process" EXACT []
synonym: "upregulation of interferon-alpha biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045354 ! regulation of interferon-alpha biosynthetic process
relationship: positively_regulates GO:0045349 ! interferon-alpha biosynthetic process

[Term]
id: GO:0045357
name: regulation of interferon-beta biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators]
synonym: "regulation of interferon-beta anabolism" EXACT []
synonym: "regulation of interferon-beta biosynthesis" EXACT []
synonym: "regulation of interferon-beta formation" EXACT []
synonym: "regulation of interferon-beta synthesis" EXACT []
is_a: GO:0032648 ! regulation of interferon-beta production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0045350 ! interferon-beta biosynthetic process

[Term]
id: GO:0045358
name: negative regulation of interferon-beta biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators]
synonym: "down regulation of interferon-beta biosynthetic process" EXACT []
synonym: "down-regulation of interferon-beta biosynthetic process" EXACT []
synonym: "downregulation of interferon-beta biosynthetic process" EXACT []
synonym: "inhibition of interferon-beta biosynthetic process" NARROW []
synonym: "negative regulation of interferon-beta anabolism" EXACT []
synonym: "negative regulation of interferon-beta biosynthesis" EXACT []
synonym: "negative regulation of interferon-beta formation" EXACT []
synonym: "negative regulation of interferon-beta synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045357 ! regulation of interferon-beta biosynthetic process
relationship: negatively_regulates GO:0045350 ! interferon-beta biosynthetic process

[Term]
id: GO:0045359
name: positive regulation of interferon-beta biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators]
synonym: "activation of interferon-beta biosynthetic process" NARROW []
synonym: "positive regulation of interferon-beta anabolism" EXACT []
synonym: "positive regulation of interferon-beta biosynthesis" EXACT []
synonym: "positive regulation of interferon-beta formation" EXACT []
synonym: "positive regulation of interferon-beta synthesis" EXACT []
synonym: "stimulation of interferon-beta biosynthetic process" NARROW []
synonym: "up regulation of interferon-beta biosynthetic process" EXACT []
synonym: "up-regulation of interferon-beta biosynthetic process" EXACT []
synonym: "upregulation of interferon-beta biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045357 ! regulation of interferon-beta biosynthetic process
relationship: positively_regulates GO:0045350 ! interferon-beta biosynthetic process

[Term]
id: GO:0045360
name: regulation of interleukin-1 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators]
synonym: "regulation of IL-1 biosynthesis" EXACT []
synonym: "regulation of IL-1 biosynthetic process" EXACT []
synonym: "regulation of interleukin-1 anabolism" EXACT []
synonym: "regulation of interleukin-1 biosynthesis" EXACT []
synonym: "regulation of interleukin-1 formation" EXACT []
synonym: "regulation of interleukin-1 synthesis" EXACT []
is_a: GO:0032652 ! regulation of interleukin-1 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042222 ! interleukin-1 biosynthetic process

[Term]
id: GO:0045361
name: negative regulation of interleukin-1 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators]
synonym: "down regulation of interleukin-1 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-1 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-1 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-1 biosynthetic process" NARROW []
synonym: "negative regulation of IL-1 biosynthesis" EXACT []
synonym: "negative regulation of IL-1 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-1 anabolism" EXACT []
synonym: "negative regulation of interleukin-1 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-1 formation" EXACT []
synonym: "negative regulation of interleukin-1 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process
relationship: negatively_regulates GO:0042222 ! interleukin-1 biosynthetic process

[Term]
id: GO:0045362
name: positive regulation of interleukin-1 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators]
synonym: "activation of interleukin-1 biosynthetic process" NARROW []
synonym: "positive regulation of IL-1 biosynthesis" EXACT []
synonym: "positive regulation of IL-1 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-1 anabolism" EXACT []
synonym: "positive regulation of interleukin-1 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-1 formation" EXACT []
synonym: "positive regulation of interleukin-1 synthesis" EXACT []
synonym: "stimulation of interleukin-1 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-1 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-1 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-1 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process
relationship: positively_regulates GO:0042222 ! interleukin-1 biosynthetic process

[Term]
id: GO:0045363
name: regulation of interleukin-11 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators]
synonym: "regulation of IL-11 biosynthesis" EXACT []
synonym: "regulation of IL-11 biosynthetic process" EXACT []
synonym: "regulation of interleukin-11 anabolism" EXACT []
synonym: "regulation of interleukin-11 biosynthesis" EXACT []
synonym: "regulation of interleukin-11 formation" EXACT []
synonym: "regulation of interleukin-11 synthesis" EXACT []
is_a: GO:0032654 ! regulation of interleukin-11 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042230 ! interleukin-11 biosynthetic process

[Term]
id: GO:0045364
name: negative regulation of interleukin-11 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators]
synonym: "down regulation of interleukin-11 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-11 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-11 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-11 biosynthetic process" NARROW []
synonym: "negative regulation of IL-11 biosynthesis" EXACT []
synonym: "negative regulation of IL-11 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-11 anabolism" EXACT []
synonym: "negative regulation of interleukin-11 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-11 formation" EXACT []
synonym: "negative regulation of interleukin-11 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045363 ! regulation of interleukin-11 biosynthetic process
relationship: negatively_regulates GO:0042230 ! interleukin-11 biosynthetic process

[Term]
id: GO:0045365
name: positive regulation of interleukin-11 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators]
synonym: "activation of interleukin-11 biosynthetic process" NARROW []
synonym: "positive regulation of IL-11 biosynthesis" EXACT []
synonym: "positive regulation of IL-11 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-11 anabolism" EXACT []
synonym: "positive regulation of interleukin-11 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-11 formation" EXACT []
synonym: "positive regulation of interleukin-11 synthesis" EXACT []
synonym: "stimulation of interleukin-11 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-11 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-11 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-11 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045363 ! regulation of interleukin-11 biosynthetic process
relationship: positively_regulates GO:0042230 ! interleukin-11 biosynthetic process

[Term]
id: GO:0045366
name: regulation of interleukin-13 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators]
synonym: "regulation of IL-13 biosynthesis" EXACT []
synonym: "regulation of IL-13 biosynthetic process" EXACT []
synonym: "regulation of interleukin-13 anabolism" EXACT []
synonym: "regulation of interleukin-13 biosynthesis" EXACT []
synonym: "regulation of interleukin-13 formation" EXACT []
synonym: "regulation of interleukin-13 synthesis" EXACT []
is_a: GO:0032656 ! regulation of interleukin-13 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042231 ! interleukin-13 biosynthetic process

[Term]
id: GO:0045367
name: negative regulation of interleukin-13 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators]
synonym: "down regulation of interleukin-13 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-13 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-13 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-13 biosynthetic process" NARROW []
synonym: "negative regulation of IL-13 biosynthesis" EXACT []
synonym: "negative regulation of IL-13 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-13 anabolism" EXACT []
synonym: "negative regulation of interleukin-13 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-13 formation" EXACT []
synonym: "negative regulation of interleukin-13 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045366 ! regulation of interleukin-13 biosynthetic process
relationship: negatively_regulates GO:0042231 ! interleukin-13 biosynthetic process

[Term]
id: GO:0045368
name: positive regulation of interleukin-13 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators]
synonym: "activation of interleukin-13 biosynthetic process" NARROW []
synonym: "positive regulation of IL-13 biosynthesis" EXACT []
synonym: "positive regulation of IL-13 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-13 anabolism" EXACT []
synonym: "positive regulation of interleukin-13 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-13 formation" EXACT []
synonym: "positive regulation of interleukin-13 synthesis" EXACT []
synonym: "stimulation of interleukin-13 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-13 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-13 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-13 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045366 ! regulation of interleukin-13 biosynthetic process
relationship: positively_regulates GO:0042231 ! interleukin-13 biosynthetic process

[Term]
id: GO:0045369
name: regulation of interleukin-14 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators]
synonym: "regulation of IL-14 biosynthesis" EXACT []
synonym: "regulation of IL-14 biosynthetic process" EXACT []
synonym: "regulation of interleukin-14 anabolism" EXACT []
synonym: "regulation of interleukin-14 biosynthesis" EXACT []
synonym: "regulation of interleukin-14 formation" EXACT []
synonym: "regulation of interleukin-14 synthesis" EXACT []
is_a: GO:0032657 ! regulation of interleukin-14 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042232 ! interleukin-14 biosynthetic process

[Term]
id: GO:0045370
name: negative regulation of interleukin-14 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators]
synonym: "down regulation of interleukin-14 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-14 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-14 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-14 biosynthetic process" NARROW []
synonym: "negative regulation of IL-14 biosynthesis" EXACT []
synonym: "negative regulation of IL-14 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-14 anabolism" EXACT []
synonym: "negative regulation of interleukin-14 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-14 formation" EXACT []
synonym: "negative regulation of interleukin-14 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045369 ! regulation of interleukin-14 biosynthetic process
relationship: negatively_regulates GO:0042232 ! interleukin-14 biosynthetic process

[Term]
id: GO:0045371
name: positive regulation of interleukin-14 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators]
synonym: "activation of interleukin-14 biosynthetic process" NARROW []
synonym: "positive regulation of IL-14 biosynthesis" EXACT []
synonym: "positive regulation of IL-14 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-14 anabolism" EXACT []
synonym: "positive regulation of interleukin-14 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-14 formation" EXACT []
synonym: "positive regulation of interleukin-14 synthesis" EXACT []
synonym: "stimulation of interleukin-14 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-14 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-14 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-14 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045369 ! regulation of interleukin-14 biosynthetic process
relationship: positively_regulates GO:0042232 ! interleukin-14 biosynthetic process

[Term]
id: GO:0045372
name: regulation of interleukin-15 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators]
synonym: "regulation of IL-15 biosynthesis" EXACT []
synonym: "regulation of IL-15 biosynthetic process" EXACT []
synonym: "regulation of interleukin-15 anabolism" EXACT []
synonym: "regulation of interleukin-15 biosynthesis" EXACT []
synonym: "regulation of interleukin-15 formation" EXACT []
synonym: "regulation of interleukin-15 synthesis" EXACT []
is_a: GO:0032658 ! regulation of interleukin-15 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042233 ! interleukin-15 biosynthetic process

[Term]
id: GO:0045373
name: negative regulation of interleukin-15 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators]
synonym: "down regulation of interleukin-15 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-15 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-15 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-15 biosynthetic process" NARROW []
synonym: "negative regulation of IL-15 biosynthesis" EXACT []
synonym: "negative regulation of IL-15 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-15 anabolism" EXACT []
synonym: "negative regulation of interleukin-15 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-15 formation" EXACT []
synonym: "negative regulation of interleukin-15 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045372 ! regulation of interleukin-15 biosynthetic process
relationship: negatively_regulates GO:0042233 ! interleukin-15 biosynthetic process

[Term]
id: GO:0045374
name: positive regulation of interleukin-15 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators]
synonym: "activation of interleukin-15 biosynthetic process" NARROW []
synonym: "positive regulation of IL-15 biosynthesis" EXACT []
synonym: "positive regulation of IL-15 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-15 anabolism" EXACT []
synonym: "positive regulation of interleukin-15 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-15 formation" EXACT []
synonym: "positive regulation of interleukin-15 synthesis" EXACT []
synonym: "stimulation of interleukin-15 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-15 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-15 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-15 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045372 ! regulation of interleukin-15 biosynthetic process
relationship: positively_regulates GO:0042233 ! interleukin-15 biosynthetic process

[Term]
id: GO:0045375
name: regulation of interleukin-16 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators]
synonym: "regulation of IL-16 biosynthesis" EXACT []
synonym: "regulation of IL-16 biosynthetic process" EXACT []
synonym: "regulation of interleukin-16 anabolism" EXACT []
synonym: "regulation of interleukin-16 biosynthesis" EXACT []
synonym: "regulation of interleukin-16 formation" EXACT []
synonym: "regulation of interleukin-16 synthesis" EXACT []
is_a: GO:0032659 ! regulation of interleukin-16 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042234 ! interleukin-16 biosynthetic process

[Term]
id: GO:0045376
name: negative regulation of interleukin-16 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators]
synonym: "down regulation of interleukin-16 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-16 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-16 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-16 biosynthetic process" NARROW []
synonym: "negative regulation of IL-16 biosynthesis" EXACT []
synonym: "negative regulation of IL-16 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-16 anabolism" EXACT []
synonym: "negative regulation of interleukin-16 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-16 formation" EXACT []
synonym: "negative regulation of interleukin-16 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045375 ! regulation of interleukin-16 biosynthetic process
relationship: negatively_regulates GO:0042234 ! interleukin-16 biosynthetic process

[Term]
id: GO:0045377
name: positive regulation of interleukin-16 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators]
synonym: "activation of interleukin-16 biosynthetic process" NARROW []
synonym: "positive regulation of IL-16 biosynthesis" EXACT []
synonym: "positive regulation of IL-16 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-16 anabolism" EXACT []
synonym: "positive regulation of interleukin-16 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-16 formation" EXACT []
synonym: "positive regulation of interleukin-16 synthesis" EXACT []
synonym: "stimulation of interleukin-16 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-16 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-16 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-16 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045375 ! regulation of interleukin-16 biosynthetic process
relationship: positively_regulates GO:0042234 ! interleukin-16 biosynthetic process

[Term]
id: GO:0045378
name: regulation of interleukin-17 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-17." [GOC:go_curators]
synonym: "regulation of IL-17 biosynthesis" EXACT []
synonym: "regulation of IL-17 biosynthetic process" EXACT []
synonym: "regulation of interleukin-17 anabolism" EXACT []
synonym: "regulation of interleukin-17 biosynthesis" EXACT []
synonym: "regulation of interleukin-17 formation" EXACT []
synonym: "regulation of interleukin-17 synthesis" EXACT []
is_a: GO:0032660 ! regulation of interleukin-17 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042235 ! interleukin-17 biosynthetic process

[Term]
id: GO:0045379
name: negative regulation of interleukin-17 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-17." [GOC:go_curators]
synonym: "down regulation of interleukin-17 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-17 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-17 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-17 biosynthetic process" NARROW []
synonym: "negative regulation of IL-17 biosynthesis" EXACT []
synonym: "negative regulation of IL-17 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-17 anabolism" EXACT []
synonym: "negative regulation of interleukin-17 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-17 formation" EXACT []
synonym: "negative regulation of interleukin-17 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process
relationship: negatively_regulates GO:0042235 ! interleukin-17 biosynthetic process

[Term]
id: GO:0045380
name: positive regulation of interleukin-17 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-17." [GOC:go_curators]
synonym: "activation of interleukin-17 biosynthetic process" NARROW []
synonym: "positive regulation of IL-17 biosynthesis" EXACT []
synonym: "positive regulation of IL-17 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-17 anabolism" EXACT []
synonym: "positive regulation of interleukin-17 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-17 formation" EXACT []
synonym: "positive regulation of interleukin-17 synthesis" EXACT []
synonym: "stimulation of interleukin-17 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-17 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-17 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-17 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045378 ! regulation of interleukin-17 biosynthetic process
relationship: positively_regulates GO:0042235 ! interleukin-17 biosynthetic process

[Term]
id: GO:0045381
name: regulation of interleukin-18 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators]
synonym: "regulation of IL-18 biosynthesis" EXACT []
synonym: "regulation of IL-18 biosynthetic process" EXACT []
synonym: "regulation of interleukin-18 anabolism" EXACT []
synonym: "regulation of interleukin-18 biosynthesis" EXACT []
synonym: "regulation of interleukin-18 formation" EXACT []
synonym: "regulation of interleukin-18 synthesis" EXACT []
is_a: GO:0032661 ! regulation of interleukin-18 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042241 ! interleukin-18 biosynthetic process

[Term]
id: GO:0045382
name: negative regulation of interleukin-18 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators]
synonym: "down regulation of interleukin-18 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-18 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-18 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-18 biosynthetic process" NARROW []
synonym: "negative regulation of IL-18 biosynthesis" EXACT []
synonym: "negative regulation of IL-18 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-18 anabolism" EXACT []
synonym: "negative regulation of interleukin-18 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-18 formation" EXACT []
synonym: "negative regulation of interleukin-18 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045381 ! regulation of interleukin-18 biosynthetic process
relationship: negatively_regulates GO:0042241 ! interleukin-18 biosynthetic process

[Term]
id: GO:0045383
name: positive regulation of interleukin-18 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators]
synonym: "activation of interleukin-18 biosynthetic process" NARROW []
synonym: "positive regulation of IL-18 biosynthesis" EXACT []
synonym: "positive regulation of IL-18 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-18 anabolism" EXACT []
synonym: "positive regulation of interleukin-18 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-18 formation" EXACT []
synonym: "positive regulation of interleukin-18 synthesis" EXACT []
synonym: "stimulation of interleukin-18 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-18 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-18 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-18 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045381 ! regulation of interleukin-18 biosynthetic process
relationship: positively_regulates GO:0042241 ! interleukin-18 biosynthetic process

[Term]
id: GO:0045384
name: regulation of interleukin-19 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators]
synonym: "regulation of IL-19 biosynthesis" EXACT []
synonym: "regulation of IL-19 biosynthetic process" EXACT []
synonym: "regulation of interleukin-19 anabolism" EXACT []
synonym: "regulation of interleukin-19 biosynthesis" EXACT []
synonym: "regulation of interleukin-19 formation" EXACT []
synonym: "regulation of interleukin-19 synthesis" EXACT []
is_a: GO:0032662 ! regulation of interleukin-19 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042236 ! interleukin-19 biosynthetic process

[Term]
id: GO:0045385
name: negative regulation of interleukin-19 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators]
synonym: "down regulation of interleukin-19 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-19 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-19 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-19 biosynthetic process" NARROW []
synonym: "negative regulation of IL-19 biosynthesis" EXACT []
synonym: "negative regulation of IL-19 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-19 anabolism" EXACT []
synonym: "negative regulation of interleukin-19 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-19 formation" EXACT []
synonym: "negative regulation of interleukin-19 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045384 ! regulation of interleukin-19 biosynthetic process
relationship: negatively_regulates GO:0042236 ! interleukin-19 biosynthetic process

[Term]
id: GO:0045386
name: positive regulation of interleukin-19 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators]
synonym: "activation of interleukin-19 biosynthetic process" NARROW []
synonym: "positive regulation of IL-19 biosynthesis" EXACT []
synonym: "positive regulation of IL-19 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-19 anabolism" EXACT []
synonym: "positive regulation of interleukin-19 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-19 formation" EXACT []
synonym: "positive regulation of interleukin-19 synthesis" EXACT []
synonym: "stimulation of interleukin-19 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-19 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-19 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-19 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045384 ! regulation of interleukin-19 biosynthetic process
relationship: positively_regulates GO:0042236 ! interleukin-19 biosynthetic process

[Term]
id: GO:0045387
name: regulation of interleukin-20 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators]
synonym: "regulation of IL-20 biosynthesis" EXACT []
synonym: "regulation of IL-20 biosynthetic process" EXACT []
synonym: "regulation of interleukin-20 anabolism" EXACT []
synonym: "regulation of interleukin-20 biosynthesis" EXACT []
synonym: "regulation of interleukin-20 formation" EXACT []
synonym: "regulation of interleukin-20 synthesis" EXACT []
is_a: GO:0032664 ! regulation of interleukin-20 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042237 ! interleukin-20 biosynthetic process

[Term]
id: GO:0045388
name: negative regulation of interleukin-20 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators]
synonym: "down regulation of interleukin-20 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-20 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-20 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-20 biosynthetic process" NARROW []
synonym: "negative regulation of IL-20 biosynthesis" EXACT []
synonym: "negative regulation of IL-20 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-20 anabolism" EXACT []
synonym: "negative regulation of interleukin-20 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-20 formation" EXACT []
synonym: "negative regulation of interleukin-20 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045387 ! regulation of interleukin-20 biosynthetic process
relationship: negatively_regulates GO:0042237 ! interleukin-20 biosynthetic process

[Term]
id: GO:0045389
name: positive regulation of interleukin-20 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators]
synonym: "activation of interleukin-20 biosynthetic process" NARROW []
synonym: "positive regulation of IL-20 biosynthesis" EXACT []
synonym: "positive regulation of IL-20 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-20 anabolism" EXACT []
synonym: "positive regulation of interleukin-20 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-20 formation" EXACT []
synonym: "positive regulation of interleukin-20 synthesis" EXACT []
synonym: "stimulation of interleukin-20 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-20 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-20 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-20 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045387 ! regulation of interleukin-20 biosynthetic process
relationship: positively_regulates GO:0042237 ! interleukin-20 biosynthetic process

[Term]
id: GO:0045390
name: regulation of interleukin-21 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators]
synonym: "regulation of IL-21 biosynthesis" EXACT []
synonym: "regulation of IL-21 biosynthetic process" EXACT []
synonym: "regulation of interleukin-21 anabolism" EXACT []
synonym: "regulation of interleukin-21 biosynthesis" EXACT []
synonym: "regulation of interleukin-21 formation" EXACT []
synonym: "regulation of interleukin-21 synthesis" EXACT []
is_a: GO:0032665 ! regulation of interleukin-21 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042238 ! interleukin-21 biosynthetic process

[Term]
id: GO:0045391
name: negative regulation of interleukin-21 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators]
synonym: "down regulation of interleukin-21 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-21 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-21 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-21 biosynthetic process" NARROW []
synonym: "negative regulation of IL-21 biosynthesis" EXACT []
synonym: "negative regulation of IL-21 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-21 anabolism" EXACT []
synonym: "negative regulation of interleukin-21 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-21 formation" EXACT []
synonym: "negative regulation of interleukin-21 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045390 ! regulation of interleukin-21 biosynthetic process
relationship: negatively_regulates GO:0042238 ! interleukin-21 biosynthetic process

[Term]
id: GO:0045392
name: positive regulation of interleukin-21 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators]
synonym: "activation of interleukin-21 biosynthetic process" NARROW []
synonym: "positive regulation of IL-21 biosynthesis" EXACT []
synonym: "positive regulation of IL-21 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-21 anabolism" EXACT []
synonym: "positive regulation of interleukin-21 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-21 formation" EXACT []
synonym: "positive regulation of interleukin-21 synthesis" EXACT []
synonym: "stimulation of interleukin-21 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-21 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-21 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-21 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045390 ! regulation of interleukin-21 biosynthetic process
relationship: positively_regulates GO:0042238 ! interleukin-21 biosynthetic process

[Term]
id: GO:0045393
name: regulation of interleukin-22 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators]
synonym: "regulation of IL-22 biosynthesis" EXACT []
synonym: "regulation of IL-22 biosynthetic process" EXACT []
synonym: "regulation of interleukin-22 anabolism" EXACT []
synonym: "regulation of interleukin-22 biosynthesis" EXACT []
synonym: "regulation of interleukin-22 formation" EXACT []
synonym: "regulation of interleukin-22 synthesis" EXACT []
is_a: GO:0032666 ! regulation of interleukin-22 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042239 ! interleukin-22 biosynthetic process

[Term]
id: GO:0045394
name: negative regulation of interleukin-22 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators]
synonym: "down regulation of interleukin-22 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-22 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-22 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-22 biosynthetic process" NARROW []
synonym: "negative regulation of IL-22 biosynthesis" EXACT []
synonym: "negative regulation of IL-22 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-22 anabolism" EXACT []
synonym: "negative regulation of interleukin-22 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-22 formation" EXACT []
synonym: "negative regulation of interleukin-22 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045393 ! regulation of interleukin-22 biosynthetic process
relationship: negatively_regulates GO:0042239 ! interleukin-22 biosynthetic process

[Term]
id: GO:0045395
name: positive regulation of interleukin-22 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators]
synonym: "activation of interleukin-22 biosynthetic process" NARROW []
synonym: "positive regulation of IL-22 biosynthesis" EXACT []
synonym: "positive regulation of IL-22 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-22 anabolism" EXACT []
synonym: "positive regulation of interleukin-22 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-22 formation" EXACT []
synonym: "positive regulation of interleukin-22 synthesis" EXACT []
synonym: "stimulation of interleukin-22 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-22 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-22 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-22 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045393 ! regulation of interleukin-22 biosynthetic process
relationship: positively_regulates GO:0042239 ! interleukin-22 biosynthetic process

[Term]
id: GO:0045396
name: regulation of interleukin-23 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators]
synonym: "regulation of IL-23 biosynthesis" EXACT []
synonym: "regulation of IL-23 biosynthetic process" EXACT []
synonym: "regulation of interleukin-23 anabolism" EXACT []
synonym: "regulation of interleukin-23 biosynthesis" EXACT []
synonym: "regulation of interleukin-23 formation" EXACT []
synonym: "regulation of interleukin-23 synthesis" EXACT []
is_a: GO:0032667 ! regulation of interleukin-23 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042240 ! interleukin-23 biosynthetic process

[Term]
id: GO:0045397
name: negative regulation of interleukin-23 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators]
synonym: "down regulation of interleukin-23 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-23 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-23 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-23 biosynthetic process" NARROW []
synonym: "negative regulation of IL-23 biosynthesis" EXACT []
synonym: "negative regulation of IL-23 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-23 anabolism" EXACT []
synonym: "negative regulation of interleukin-23 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-23 formation" EXACT []
synonym: "negative regulation of interleukin-23 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045396 ! regulation of interleukin-23 biosynthetic process
relationship: negatively_regulates GO:0042240 ! interleukin-23 biosynthetic process

[Term]
id: GO:0045398
name: positive regulation of interleukin-23 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators]
synonym: "activation of interleukin-23 biosynthetic process" NARROW []
synonym: "positive regulation of IL-23 biosynthesis" EXACT []
synonym: "positive regulation of IL-23 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-23 anabolism" EXACT []
synonym: "positive regulation of interleukin-23 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-23 formation" EXACT []
synonym: "positive regulation of interleukin-23 synthesis" EXACT []
synonym: "stimulation of interleukin-23 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-23 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-23 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-23 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045396 ! regulation of interleukin-23 biosynthetic process
relationship: positively_regulates GO:0042240 ! interleukin-23 biosynthetic process

[Term]
id: GO:0045399
name: regulation of interleukin-3 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators]
synonym: "regulation of IL-3 biosynthesis" EXACT []
synonym: "regulation of IL-3 biosynthetic process" EXACT []
synonym: "regulation of interleukin-3 anabolism" EXACT []
synonym: "regulation of interleukin-3 biosynthesis" EXACT []
synonym: "regulation of interleukin-3 formation" EXACT []
synonym: "regulation of interleukin-3 synthesis" EXACT []
is_a: GO:0032672 ! regulation of interleukin-3 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042223 ! interleukin-3 biosynthetic process

[Term]
id: GO:0045400
name: negative regulation of interleukin-3 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators]
synonym: "down regulation of interleukin-3 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-3 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-3 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-3 biosynthetic process" NARROW []
synonym: "negative regulation of IL-3 biosynthesis" EXACT []
synonym: "negative regulation of IL-3 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-3 anabolism" EXACT []
synonym: "negative regulation of interleukin-3 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-3 formation" EXACT []
synonym: "negative regulation of interleukin-3 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045399 ! regulation of interleukin-3 biosynthetic process
relationship: negatively_regulates GO:0042223 ! interleukin-3 biosynthetic process

[Term]
id: GO:0045401
name: positive regulation of interleukin-3 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators]
synonym: "activation of interleukin-3 biosynthetic process" NARROW []
synonym: "positive regulation of IL-3 biosynthesis" EXACT []
synonym: "positive regulation of IL-3 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-3 anabolism" EXACT []
synonym: "positive regulation of interleukin-3 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-3 formation" EXACT []
synonym: "positive regulation of interleukin-3 synthesis" EXACT []
synonym: "stimulation of interleukin-3 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-3 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-3 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-3 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045399 ! regulation of interleukin-3 biosynthetic process
relationship: positively_regulates GO:0042223 ! interleukin-3 biosynthetic process

[Term]
id: GO:0045402
name: regulation of interleukin-4 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators]
synonym: "regulation of IL-4 biosynthesis" EXACT []
synonym: "regulation of IL-4 biosynthetic process" EXACT []
synonym: "regulation of interleukin-4 anabolism" EXACT []
synonym: "regulation of interleukin-4 biosynthesis" EXACT []
synonym: "regulation of interleukin-4 formation" EXACT []
synonym: "regulation of interleukin-4 synthesis" EXACT []
is_a: GO:0032673 ! regulation of interleukin-4 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042097 ! interleukin-4 biosynthetic process

[Term]
id: GO:0045403
name: negative regulation of interleukin-4 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators]
synonym: "down regulation of interleukin-4 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-4 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-4 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-4 biosynthetic process" NARROW []
synonym: "negative regulation of IL-4 biosynthesis" EXACT []
synonym: "negative regulation of IL-4 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-4 anabolism" EXACT []
synonym: "negative regulation of interleukin-4 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-4 formation" EXACT []
synonym: "negative regulation of interleukin-4 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045402 ! regulation of interleukin-4 biosynthetic process
relationship: negatively_regulates GO:0042097 ! interleukin-4 biosynthetic process

[Term]
id: GO:0045404
name: positive regulation of interleukin-4 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators]
synonym: "activation of interleukin-4 biosynthetic process" NARROW []
synonym: "positive regulation of IL-4 biosynthesis" EXACT []
synonym: "positive regulation of IL-4 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-4 anabolism" EXACT []
synonym: "positive regulation of interleukin-4 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-4 formation" EXACT []
synonym: "positive regulation of interleukin-4 synthesis" EXACT []
synonym: "stimulation of interleukin-4 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-4 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-4 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-4 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045402 ! regulation of interleukin-4 biosynthetic process
relationship: positively_regulates GO:0042097 ! interleukin-4 biosynthetic process

[Term]
id: GO:0045405
name: regulation of interleukin-5 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators]
synonym: "regulation of IL-5 biosynthesis" EXACT []
synonym: "regulation of IL-5 biosynthetic process" EXACT []
synonym: "regulation of interleukin-5 anabolism" EXACT []
synonym: "regulation of interleukin-5 biosynthesis" EXACT []
synonym: "regulation of interleukin-5 formation" EXACT []
synonym: "regulation of interleukin-5 synthesis" EXACT []
is_a: GO:0032674 ! regulation of interleukin-5 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042225 ! interleukin-5 biosynthetic process

[Term]
id: GO:0045406
name: negative regulation of interleukin-5 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators]
synonym: "down regulation of interleukin-5 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-5 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-5 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-5 biosynthetic process" NARROW []
synonym: "negative regulation of IL-5 biosynthesis" EXACT []
synonym: "negative regulation of IL-5 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-5 anabolism" EXACT []
synonym: "negative regulation of interleukin-5 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-5 formation" EXACT []
synonym: "negative regulation of interleukin-5 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045405 ! regulation of interleukin-5 biosynthetic process
relationship: negatively_regulates GO:0042225 ! interleukin-5 biosynthetic process

[Term]
id: GO:0045407
name: positive regulation of interleukin-5 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators]
synonym: "activation of interleukin-5 biosynthetic process" NARROW []
synonym: "positive regulation of IL-5 biosynthesis" EXACT []
synonym: "positive regulation of IL-5 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-5 anabolism" EXACT []
synonym: "positive regulation of interleukin-5 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-5 formation" EXACT []
synonym: "positive regulation of interleukin-5 synthesis" EXACT []
synonym: "stimulation of interleukin-5 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-5 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-5 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-5 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045405 ! regulation of interleukin-5 biosynthetic process
relationship: positively_regulates GO:0042225 ! interleukin-5 biosynthetic process

[Term]
id: GO:0045408
name: regulation of interleukin-6 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators]
synonym: "regulation of IL-6 biosynthesis" EXACT []
synonym: "regulation of IL-6 biosynthetic process" EXACT []
synonym: "regulation of interleukin-6 anabolism" EXACT []
synonym: "regulation of interleukin-6 biosynthesis" EXACT []
synonym: "regulation of interleukin-6 formation" EXACT []
synonym: "regulation of interleukin-6 synthesis" EXACT []
is_a: GO:0032675 ! regulation of interleukin-6 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042226 ! interleukin-6 biosynthetic process

[Term]
id: GO:0045409
name: negative regulation of interleukin-6 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators]
synonym: "down regulation of interleukin-6 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-6 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-6 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-6 biosynthetic process" NARROW []
synonym: "negative regulation of IL-6 biosynthesis" EXACT []
synonym: "negative regulation of IL-6 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-6 anabolism" EXACT []
synonym: "negative regulation of interleukin-6 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-6 formation" EXACT []
synonym: "negative regulation of interleukin-6 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045408 ! regulation of interleukin-6 biosynthetic process
relationship: negatively_regulates GO:0042226 ! interleukin-6 biosynthetic process

[Term]
id: GO:0045410
name: positive regulation of interleukin-6 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators]
synonym: "activation of interleukin-6 biosynthetic process" NARROW []
synonym: "positive regulation of IL-6 biosynthesis" EXACT []
synonym: "positive regulation of IL-6 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-6 anabolism" EXACT []
synonym: "positive regulation of interleukin-6 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-6 formation" EXACT []
synonym: "positive regulation of interleukin-6 synthesis" EXACT []
synonym: "stimulation of interleukin-6 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-6 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-6 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-6 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045408 ! regulation of interleukin-6 biosynthetic process
relationship: positively_regulates GO:0042226 ! interleukin-6 biosynthetic process

[Term]
id: GO:0045411
name: regulation of interleukin-7 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators]
synonym: "regulation of IL-7 biosynthesis" EXACT []
synonym: "regulation of IL-7 biosynthetic process" EXACT []
synonym: "regulation of interleukin-7 anabolism" EXACT []
synonym: "regulation of interleukin-7 biosynthesis" EXACT []
synonym: "regulation of interleukin-7 formation" EXACT []
synonym: "regulation of interleukin-7 synthesis" EXACT []
is_a: GO:0032676 ! regulation of interleukin-7 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042227 ! interleukin-7 biosynthetic process

[Term]
id: GO:0045412
name: negative regulation of interleukin-7 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators]
synonym: "down regulation of interleukin-7 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-7 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-7 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-7 biosynthetic process" NARROW []
synonym: "negative regulation of IL-7 biosynthesis" EXACT []
synonym: "negative regulation of IL-7 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-7 anabolism" EXACT []
synonym: "negative regulation of interleukin-7 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-7 formation" EXACT []
synonym: "negative regulation of interleukin-7 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045411 ! regulation of interleukin-7 biosynthetic process
relationship: negatively_regulates GO:0042227 ! interleukin-7 biosynthetic process

[Term]
id: GO:0045413
name: positive regulation of interleukin-7 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators]
synonym: "activation of interleukin-7 biosynthetic process" NARROW []
synonym: "positive regulation of IL-7 biosynthesis" EXACT []
synonym: "positive regulation of IL-7 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-7 anabolism" EXACT []
synonym: "positive regulation of interleukin-7 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-7 formation" EXACT []
synonym: "positive regulation of interleukin-7 synthesis" EXACT []
synonym: "stimulation of interleukin-7 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-7 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-7 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-7 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045411 ! regulation of interleukin-7 biosynthetic process
relationship: positively_regulates GO:0042227 ! interleukin-7 biosynthetic process

[Term]
id: GO:0045414
name: regulation of interleukin-8 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators]
synonym: "regulation of IL-8 biosynthesis" EXACT []
synonym: "regulation of IL-8 biosynthetic process" EXACT []
synonym: "regulation of interleukin-8 anabolism" EXACT []
synonym: "regulation of interleukin-8 biosynthesis" EXACT []
synonym: "regulation of interleukin-8 formation" EXACT []
synonym: "regulation of interleukin-8 synthesis" EXACT []
is_a: GO:0032677 ! regulation of interleukin-8 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042228 ! interleukin-8 biosynthetic process

[Term]
id: GO:0045415
name: negative regulation of interleukin-8 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators]
synonym: "down regulation of interleukin-8 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-8 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-8 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-8 biosynthetic process" NARROW []
synonym: "negative regulation of IL-8 biosynthesis" EXACT []
synonym: "negative regulation of IL-8 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-8 anabolism" EXACT []
synonym: "negative regulation of interleukin-8 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-8 formation" EXACT []
synonym: "negative regulation of interleukin-8 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045414 ! regulation of interleukin-8 biosynthetic process
relationship: negatively_regulates GO:0042228 ! interleukin-8 biosynthetic process

[Term]
id: GO:0045416
name: positive regulation of interleukin-8 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators]
synonym: "activation of interleukin-8 biosynthetic process" NARROW []
synonym: "positive regulation of IL-8 biosynthesis" EXACT []
synonym: "positive regulation of IL-8 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-8 anabolism" EXACT []
synonym: "positive regulation of interleukin-8 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-8 formation" EXACT []
synonym: "positive regulation of interleukin-8 synthesis" EXACT []
synonym: "stimulation of interleukin-8 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-8 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-8 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-8 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045414 ! regulation of interleukin-8 biosynthetic process
relationship: positively_regulates GO:0042228 ! interleukin-8 biosynthetic process

[Term]
id: GO:0045417
name: regulation of interleukin-9 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators]
synonym: "regulation of IL-9 biosynthesis" EXACT []
synonym: "regulation of IL-9 biosynthetic process" EXACT []
synonym: "regulation of interleukin-9 anabolism" EXACT []
synonym: "regulation of interleukin-9 biosynthesis" EXACT []
synonym: "regulation of interleukin-9 formation" EXACT []
synonym: "regulation of interleukin-9 synthesis" EXACT []
is_a: GO:0032678 ! regulation of interleukin-9 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042229 ! interleukin-9 biosynthetic process

[Term]
id: GO:0045418
name: negative regulation of interleukin-9 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators]
synonym: "down regulation of interleukin-9 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-9 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-9 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-9 biosynthetic process" NARROW []
synonym: "negative regulation of IL-9 biosynthesis" EXACT []
synonym: "negative regulation of IL-9 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-9 anabolism" EXACT []
synonym: "negative regulation of interleukin-9 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-9 formation" EXACT []
synonym: "negative regulation of interleukin-9 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045417 ! regulation of interleukin-9 biosynthetic process
relationship: negatively_regulates GO:0042229 ! interleukin-9 biosynthetic process

[Term]
id: GO:0045419
name: positive regulation of interleukin-9 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators]
synonym: "activation of interleukin-9 biosynthetic process" NARROW []
synonym: "positive regulation of IL-9 biosynthesis" EXACT []
synonym: "positive regulation of IL-9 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-9 anabolism" EXACT []
synonym: "positive regulation of interleukin-9 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-9 formation" EXACT []
synonym: "positive regulation of interleukin-9 synthesis" EXACT []
synonym: "stimulation of interleukin-9 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-9 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-9 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-9 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045417 ! regulation of interleukin-9 biosynthetic process
relationship: positively_regulates GO:0042229 ! interleukin-9 biosynthetic process

[Term]
id: GO:0045420
name: regulation of connective tissue growth factor biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators]
synonym: "regulation of connective tissue growth factor anabolism" EXACT []
synonym: "regulation of connective tissue growth factor biosynthesis" EXACT []
synonym: "regulation of connective tissue growth factor formation" EXACT []
synonym: "regulation of connective tissue growth factor synthesis" EXACT []
is_a: GO:0032643 ! regulation of connective tissue growth factor production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0045189 ! connective tissue growth factor biosynthetic process

[Term]
id: GO:0045421
name: negative regulation of connective tissue growth factor biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators]
synonym: "down regulation of connective tissue growth factor biosynthetic process" EXACT []
synonym: "down-regulation of connective tissue growth factor biosynthetic process" EXACT []
synonym: "downregulation of connective tissue growth factor biosynthetic process" EXACT []
synonym: "inhibition of connective tissue growth factor biosynthetic process" NARROW []
synonym: "negative regulation of connective tissue growth factor anabolism" EXACT []
synonym: "negative regulation of connective tissue growth factor biosynthesis" EXACT []
synonym: "negative regulation of connective tissue growth factor formation" EXACT []
synonym: "negative regulation of connective tissue growth factor synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045420 ! regulation of connective tissue growth factor biosynthetic process
relationship: negatively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process

[Term]
id: GO:0045422
name: positive regulation of connective tissue growth factor biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." [GOC:go_curators]
synonym: "activation of connective tissue growth factor biosynthetic process" NARROW []
synonym: "positive regulation of connective tissue growth factor anabolism" EXACT []
synonym: "positive regulation of connective tissue growth factor biosynthesis" EXACT []
synonym: "positive regulation of connective tissue growth factor formation" EXACT []
synonym: "positive regulation of connective tissue growth factor synthesis" EXACT []
synonym: "stimulation of connective tissue growth factor biosynthetic process" NARROW []
synonym: "up regulation of connective tissue growth factor biosynthetic process" EXACT []
synonym: "up-regulation of connective tissue growth factor biosynthetic process" EXACT []
synonym: "upregulation of connective tissue growth factor biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045420 ! regulation of connective tissue growth factor biosynthetic process
relationship: positively_regulates GO:0045189 ! connective tissue growth factor biosynthetic process

[Term]
id: GO:0045423
name: regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor." [GOC:go_curators]
synonym: "regulation of granulocyte macrophage colony-stimulating factor anabolism" EXACT []
synonym: "regulation of granulocyte macrophage colony-stimulating factor biosynthesis" EXACT []
synonym: "regulation of granulocyte macrophage colony-stimulating factor formation" EXACT []
synonym: "regulation of granulocyte macrophage colony-stimulating factor synthesis" EXACT []
is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process

[Term]
id: GO:0045424
name: negative regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor." [GOC:go_curators]
synonym: "down regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT []
synonym: "down-regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT []
synonym: "downregulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT []
synonym: "inhibition of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW []
synonym: "negative regulation of granulocyte macrophage colony-stimulating factor anabolism" EXACT []
synonym: "negative regulation of granulocyte macrophage colony-stimulating factor biosynthesis" EXACT []
synonym: "negative regulation of granulocyte macrophage colony-stimulating factor formation" EXACT []
synonym: "negative regulation of granulocyte macrophage colony-stimulating factor synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045423 ! regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
relationship: negatively_regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process

[Term]
id: GO:0045425
name: positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor." [GOC:go_curators]
synonym: "activation of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW []
synonym: "positive regulation of granulocyte macrophage colony-stimulating factor anabolism" EXACT []
synonym: "positive regulation of granulocyte macrophage colony-stimulating factor biosynthesis" EXACT []
synonym: "positive regulation of granulocyte macrophage colony-stimulating factor formation" EXACT []
synonym: "positive regulation of granulocyte macrophage colony-stimulating factor synthesis" EXACT []
synonym: "stimulation of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW []
synonym: "up regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT []
synonym: "up-regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT []
synonym: "upregulation of granulocyte macrophage colony-stimulating factor biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045423 ! regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
relationship: positively_regulates GO:0042253 ! granulocyte macrophage colony-stimulating factor biosynthetic process

[Term]
id: GO:0045426
name: quinone cofactor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any quinone cofactor, such as menaquinone (vitamin K2), ubiquinone (coenzyme Q) or phylloquinone (vitamin K1)." [GOC:mb]
subset: gosubset_prok
synonym: "quinone cofactor anabolism" EXACT []
synonym: "quinone cofactor biosynthesis" EXACT []
synonym: "quinone cofactor formation" EXACT []
synonym: "quinone cofactor synthesis" EXACT []
is_a: GO:0009108 ! coenzyme biosynthetic process
is_a: GO:0042375 ! quinone cofactor metabolic process

[Term]
id: GO:0045427
name: enzyme active site formation via (phospho-5'-guanosine)-L-histidine
namespace: biological_process
def: "The transient guanylylation of peptidyl-histidine to form (phospho-5'-guanosine)-L-histidine." [RESID:AA0325]
subset: gosubset_prok
xref: RESID:AA0325
is_a: GO:0018202 ! peptidyl-histidine modification
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0045428
name: regulation of nitric oxide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators]
synonym: "regulation of nitric oxide anabolism" EXACT []
synonym: "regulation of nitric oxide biosynthesis" EXACT []
synonym: "regulation of nitric oxide formation" EXACT []
synonym: "regulation of nitric oxide synthesis" EXACT []
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
relationship: regulates GO:0006809 ! nitric oxide biosynthetic process

[Term]
id: GO:0045429
name: positive regulation of nitric oxide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators]
synonym: "activation of nitric oxide biosynthetic process" NARROW []
synonym: "positive regulation of nitric oxide anabolism" EXACT []
synonym: "positive regulation of nitric oxide biosynthesis" EXACT []
synonym: "positive regulation of nitric oxide formation" EXACT []
synonym: "positive regulation of nitric oxide synthesis" EXACT []
synonym: "stimulation of nitric oxide biosynthetic process" NARROW []
synonym: "up regulation of nitric oxide biosynthetic process" EXACT []
synonym: "up-regulation of nitric oxide biosynthetic process" EXACT []
synonym: "upregulation of nitric oxide biosynthetic process" EXACT []
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045428 ! regulation of nitric oxide biosynthetic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
relationship: positively_regulates GO:0006809 ! nitric oxide biosynthetic process

[Term]
id: GO:0045430
name: chalcone isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: a chalcone = a flavanone." [EC:5.5.1.6]
synonym: "chalcone--flavonone isomerase activity" EXACT [EC:5.5.1.6]
synonym: "chalcone-flavanone isomerase activity" EXACT []
synonym: "flavanone lyase (decyclizing)" EXACT [EC:5.5.1.6]
xref: EC:5.5.1.6
xref: MetaCyc:CHALCONE-ISOMERASE-RXN
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0045431
name: flavonol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O." [EC:1.14.11.23, ISBN:0943088372, PMID:7904213]
synonym: "dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.23]
synonym: "flavonoid 2-oxoglutarate-dependent dioxygenase activity" EXACT [EC:1.14.11.23]
synonym: "FLS activity" RELATED [EC:1.14.11.23]
xref: EC:1.14.11.23
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0045433
name: male courtship behavior, veined wing generated song production
namespace: biological_process
def: "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827]
synonym: "male courtship behavior, song production" BROAD []
synonym: "male courtship behaviour, song production" BROAD []
synonym: "male courtship behaviour, veined wing generated song production" EXACT []
is_a: GO:0008049 ! male courtship behavior
relationship: part_of GO:0016545 ! male courtship behavior, veined wing vibration

[Term]
id: GO:0045434
name: negative regulation of female receptivity, post-mating
namespace: biological_process
def: "Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating." [GOC:bf, PMID:11092827]
synonym: "down regulation of female receptivity, post-mating" EXACT []
synonym: "down-regulation of female receptivity, post-mating" EXACT []
synonym: "downregulation of female receptivity, post-mating" EXACT []
synonym: "inhibition of female receptivity, post-mating" NARROW []
is_a: GO:0007621 ! negative regulation of female receptivity
is_a: GO:0046008 ! regulation of female receptivity, post-mating

[Term]
id: GO:0045435
name: lycopene epsilon cyclase activity
namespace: molecular_function
def: "Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene)." [PMID:8837512]
synonym: "lycopene cyclase" BROAD []
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0045436
name: lycopene beta cyclase activity
namespace: molecular_function
def: "Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively." [PMID:8837512]
subset: gosubset_prok
synonym: "crtL" RELATED []
synonym: "lycopene cyclase" BROAD []
xref: MetaCyc:RXN1F-150
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0045437
name: uridine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: uridine + H2O = D-ribose + uracil." [EC:3.2.2.3]
subset: gosubset_prok
synonym: "uridine hydrolase activity" EXACT []
synonym: "uridine ribohydrolase activity" EXACT [EC:3.2.2.3]
xref: EC:3.2.2.3
xref: MetaCyc:URIDINE-NUCLEOSIDASE-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0045438
name: delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity
namespace: molecular_function
def: "Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol." [PMID:1572368, PMID:2061333]
synonym: "ACV synthetase activity" BROAD []
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0045439
name: isopenicillin-N epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: isopenicillin-N = penicillin-N." [EC:5.1.1.17, KEGG_PATHWAY:map00311]
subset: gosubset_prok
synonym: "isopenicillin N epimerase activity" EXACT []
synonym: "penicillin-N 5-amino-5-carboxypentanoyl-epimerase activity" EXACT [EC:5.1.1.17]
xref: EC:5.1.1.17
xref: MetaCyc:5.1.1.17-RXN
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives

[Term]
id: GO:0045441
name: deacetoxycephalosporin C synthetase activity
namespace: molecular_function
def: "Catalysis of the formation of deacetoxycephalosporin from penicillin-N." [KEGG_PATHWAY:map00311]
synonym: "DAOCS" EXACT []
synonym: "expandase activity" EXACT []
xref: MetaCyc:1.14.20.1-RXN
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0045442
name: deacetoxycephalosporin-C hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: deacetoxycephalosporin C + 2-oxoglutarate + O2 = deacetylcephalosporin C + succinate + CO2." [EC:1.14.11.26]
synonym: "3'-methylcephem hydroxylase activity" EXACT [EC:1.14.11.26]
synonym: "beta-lactam hydroxylase activity" EXACT []
synonym: "DACS" RELATED [EC:1.14.11.26]
synonym: "DAOC hydroxylase activity" EXACT [EC:1.14.11.26]
synonym: "deacetoxycephalosporin C hydroxylase activity" EXACT [EC:1.14.11.26]
synonym: "deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.26]
synonym: "deacetylcephalosporin C synthase activity" EXACT [EC:1.14.11.26]
xref: EC:1.14.11.26
xref: MetaCyc:1.14.11.26-RXN
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0045443
name: juvenile hormone secretion
namespace: biological_process
def: "The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684]
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0045444
name: fat cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
synonym: "adipocyte cell differentiation" EXACT []
synonym: "adipocyte differentiation" EXACT []
synonym: "adipogenesis" RELATED []
synonym: "adipose cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0045445
name: myoblast differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk]
synonym: "myoblast cell differentiation" EXACT []
is_a: GO:0042692 ! muscle cell differentiation
relationship: part_of GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0045446
name: endothelial cell differentiation
namespace: biological_process
def: "The process whereby a mesodermal angioblast acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0003158 ! endothelium development

[Term]
id: GO:0045448
name: mitotic cell cycle, embryonic
namespace: biological_process
def: "The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators]
is_a: GO:0000278 ! mitotic cell cycle
relationship: part_of GO:0009790 ! embryonic development

[Term]
id: GO:0045449
name: regulation of transcription
namespace: biological_process
alt_id: GO:0061019
def: "Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "regulation of cellular transcription" EXACT []
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
relationship: regulates GO:0006350 ! transcription

[Term]
id: GO:0045450
name: bicoid mRNA localization
namespace: biological_process
def: "Any process by which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators]
synonym: "establishment and maintenance of bicoid mRNA localization" EXACT []
is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification
relationship: part_of GO:0007314 ! oocyte anterior/posterior axis specification

[Term]
id: GO:0045451
name: pole plasm oskar mRNA localization
namespace: biological_process
def: "Any process by which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
synonym: "establishment and maintenance of oskar mRNA localization in pole plasm" EXACT []
synonym: "establishment and maintenance of pole plasm oskar mRNA localization" EXACT []
synonym: "oocyte pole plasm oskar mRNA localization" EXACT []
is_a: GO:0019094 ! pole plasm mRNA localization

[Term]
id: GO:0045453
name: bone resorption
namespace: biological_process
def: "The process by which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products." [GOC:mah, PMID:10968780]
xref: Wikipedia:Bone_resorption
is_a: GO:0001894 ! tissue homeostasis
relationship: part_of GO:0046849 ! bone remodeling

[Term]
id: GO:0045454
name: cell redox homeostasis
namespace: biological_process
alt_id: GO:0030503
alt_id: GO:0045867
alt_id: GO:0045868
def: "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "regulation of cell redox homeostasis" RELATED []
synonym: "regulation of redox homeostasis" BROAD []
is_a: GO:0019725 ! cellular homeostasis
is_a: GO:0050794 ! regulation of cellular process

[Term]
id: GO:0045455
name: ecdysteroid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "ecdysteroid metabolism" EXACT []
is_a: GO:0008202 ! steroid metabolic process
is_a: GO:0034754 ! cellular hormone metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
relationship: part_of GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0045456
name: ecdysteroid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators]
synonym: "ecdysteroid anabolism" EXACT []
synonym: "ecdysteroid biosynthesis" EXACT []
synonym: "ecdysteroid formation" EXACT []
synonym: "ecdysteroid synthesis" EXACT []
is_a: GO:0006694 ! steroid biosynthetic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0042446 ! hormone biosynthetic process
is_a: GO:0045455 ! ecdysteroid metabolic process

[Term]
id: GO:0045457
name: ecdysteroid secretion
namespace: biological_process
def: "The regulated release of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators]
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0045458
name: recombination within rDNA repeats
namespace: biological_process
def: "Genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: Note that this term was reinstated from obsolete.
subset: gosubset_prok
synonym: "recombination within ribosomal DNA repeats" EXACT []
is_a: GO:0006310 ! DNA recombination
is_a: GO:0043007 ! maintenance of rDNA

[Term]
id: GO:0045459
name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide." [PMID:11592901, RESID:AA0326]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl triiron tetrasulphide" EXACT []
xref: RESID:AA0326
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0045460
name: sterigmatocystin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "sterigmatocystin metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0009404 ! toxin metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0045461
name: sterigmatocystin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "sterigmatocystin anabolism" EXACT []
synonym: "sterigmatocystin biosynthesis" EXACT []
synonym: "sterigmatocystin formation" EXACT []
synonym: "sterigmatocystin synthesis" EXACT []
is_a: GO:0009403 ! toxin biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0045460 ! sterigmatocystin metabolic process
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0045462
name: trichothecene 3-O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis." [PMID:10583973]
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0045463
name: R8 cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium." [PMID:11880339]
is_a: GO:0042051 ! compound eye photoreceptor development
relationship: part_of GO:0045465 ! R8 cell differentiation

[Term]
id: GO:0045464
name: R8 cell fate specification
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [PMID:11880339]
is_a: GO:0043704 ! photoreceptor cell fate specification
relationship: part_of GO:0007460 ! R8 cell fate commitment

[Term]
id: GO:0045465
name: R8 cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor." [PMID:11880339]
is_a: GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0045466
name: R7 cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339]
is_a: GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0045467
name: R7 cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339]
is_a: GO:0042051 ! compound eye photoreceptor development
relationship: part_of GO:0045466 ! R7 cell differentiation

[Term]
id: GO:0045468
name: regulation of R8 cell spacing in compound eye
namespace: biological_process
def: "Any process that ensures that the R8 cells are selected in a precise progressive pattern so that they are evenly spaced throughout the eye disc." [GOC:dph, GOC:tb, PMID:11880339]
synonym: "R8 cell spacing in compound eye" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of R8 spacing" EXACT [GOC:dph]
is_a: GO:0007389 ! pattern specification process
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0048749 ! compound eye development

[Term]
id: GO:0045469
name: negative regulation of R8 cell spacing in compound eye
namespace: biological_process
def: "Any process that stops or prevents the correct R8 cell spacing pattern in a compound eye." [GOC:dph, GOC:tb, PMID:11880339]
synonym: "down regulation of R8 spacing" EXACT []
synonym: "down-regulation of R8 spacing" EXACT []
synonym: "downregulation of R8 spacing" EXACT []
synonym: "inhibition of R8 spacing" NARROW []
is_a: GO:0045468 ! regulation of R8 cell spacing in compound eye

[Term]
id: GO:0045470
name: R8 cell-mediated photoreceptor organization
namespace: biological_process
def: "The regionalization process that coordinates the recruitment and organization of other non-R8 photoreceptors by the R8 photoreceptor." [PMID:11880339]
synonym: "R8-mediated photoreceptor organisation" EXACT [GOC:curators]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0042051 ! compound eye photoreceptor development

[Term]
id: GO:0045471
name: response to ethanol
namespace: biological_process
alt_id: GO:0017036
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0045472
name: response to ether
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:go_curators]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0045473
name: response to ethanol (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators, GOC:jic]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
is_obsolete: true
consider: GO:0048149

[Term]
id: GO:0045474
name: response to ether (sensu Insecta)
namespace: biological_process
def: "OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ether stimulus." [GOC:go_curators, GOC:jic]
comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term.
is_obsolete: true
consider: GO:0048150

[Term]
id: GO:0045475
name: locomotor rhythm
namespace: biological_process
def: "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators]
synonym: "circadian locomotor activity rhythm" NARROW []
is_a: GO:0007626 ! locomotory behavior
is_a: GO:0048512 ! circadian behavior

[Term]
id: GO:0045476
name: nurse cell apoptosis
namespace: biological_process
def: "The process by which nurse cells undergo apoptosis. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptosis." [PMID:11973306]
synonym: "apoptosis of nurse cells" EXACT []
synonym: "nurse cell programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of nurse cells by apoptosis" EXACT []
is_a: GO:0006915 ! apoptosis
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0045477
name: regulation of nurse cell apoptosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nurse cell apoptosis." [PMID:11973306]
is_a: GO:0042981 ! regulation of apoptosis
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0045476 ! nurse cell apoptosis

[Term]
id: GO:0045478
name: fusome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells." [GOC:dph, GOC:go_curators, GOC:jl, GOC:mah]
subset: goslim_pir
synonym: "fusome organisation" EXACT [GOC:curators]
synonym: "fusome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0045479
name: vesicle targeting to fusome
namespace: biological_process
def: "The recruitment of vesicles to the fusome. The vesicles become the fusome tubule network and are necessary for the assembly of the fusome." [PMID:9046244]
synonym: "vesicle-fusome targeting" EXACT []
is_a: GO:0006903 ! vesicle targeting
relationship: part_of GO:0045478 ! fusome organization

[Term]
id: GO:0045480
name: galactose oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + H2O2." [EC:1.1.3.9]
synonym: "beta-galactose oxidase activity" RELATED [EC:1.1.3.9]
synonym: "D-galactose oxidase activity" EXACT [EC:1.1.3.9]
synonym: "D-galactose:oxygen 6-oxidoreductase activity" EXACT [EC:1.1.3.9]
xref: EC:1.1.3.9
xref: MetaCyc:GALACTOSE-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0045481
name: 6-endo-hydroxycineole dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-endo-hydroxycineole + NAD+ = 6-oxocineole + NADH + H+." [EC:1.1.1.241]
synonym: "6-endo-hydroxycineole:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.241]
xref: EC:1.1.1.241
xref: MetaCyc:6-ENDO-HYDROXYCINEOLE-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0045482
name: trichodiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = trichodiene + diphosphate." [EC:4.2.3.6]
synonym: "sesquiterpene cyclase activity" BROAD [EC:4.2.3.6]
synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)" EXACT [EC:4.2.3.6]
synonym: "trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase activity" EXACT [EC:4.2.3.6]
synonym: "trichodiene synthetase activity" EXACT [EC:4.2.3.6]
xref: EC:4.2.3.6
xref: MetaCyc:TRICHODIENE-SYNTHASE-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0045483
name: aristolochene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate." [EC:4.2.3.9]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)" EXACT [EC:4.2.3.9]
synonym: "5-epi-aristolochene synthase activity" EXACT [EC:4.2.3.9]
synonym: "sesquiterpene cyclase activity" BROAD [EC:4.2.3.9]
synonym: "trans,trans-farnesyl diphosphate aristolochene-lyase activity" EXACT [EC:4.2.3.9]
synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)" EXACT [EC:4.2.3.9]
xref: EC:4.2.3.9
xref: MetaCyc:ARISTOLOCHENE-SYNTHASE-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0045484
name: L-lysine 6-transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + 2-oxoglutarate = 2-aminoadipate 6-semialdehyde + L-glutamate." [EC:2.6.1.36]
subset: gosubset_prok
synonym: "L-lysine aminotransferase activity" EXACT [EC:2.6.1.36]
synonym: "L-lysine transaminase activity" EXACT [EC:2.6.1.36]
synonym: "L-lysine-alpha-ketoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36]
synonym: "L-lysine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.36]
synonym: "L-lysine:2-oxoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36]
synonym: "lysine 6-aminotransferase activity" EXACT []
synonym: "lysine epsilon-aminotransferase activity" EXACT [EC:2.6.1.36]
synonym: "lysine epsilon-transaminase activity" EXACT [EC:2.6.1.36]
synonym: "lysine:2-ketoglutarate 6-aminotransferase activity" EXACT [EC:2.6.1.36]
xref: EC:2.6.1.36
xref: MetaCyc:L-LYSINE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0045485
name: omega-6 fatty acid desaturase activity
namespace: molecular_function
def: "Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain." [PMID:7846158]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0045486
name: naringenin 3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2." [EC:1.14.11.9]
synonym: "(2S)-flavanone 3-hydroxylase activity" EXACT [EC:1.14.11.9]
synonym: "flavanone 3-beta-hydroxylase activity" EXACT [EC:1.14.11.9]
synonym: "flavanone 3-dioxygenase activity" EXACT [EC:1.14.11.9]
synonym: "flavanone 3-hydroxylase activity" EXACT [EC:1.14.11.9]
synonym: "flavanone 3beta-hydroxylase activity" EXACT [EC:1.14.11.9]
synonym: "flavanone synthase I activity" EXACT [EC:1.14.11.9]
synonym: "flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.9]
synonym: "naringenin 3-hydroxylase activity" EXACT [EC:1.14.11.9]
synonym: "naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.9]
xref: EC:1.14.11.9
xref: MetaCyc:NARINGENIN-3-DIOXYGENASE-RXN
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0045487
name: gibberellin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [GOC:go_curators]
subset: gosubset_prok
synonym: "gibberellic acid breakdown" NARROW []
synonym: "gibberellic acid catabolic process" NARROW []
synonym: "gibberellic acid catabolism" NARROW []
synonym: "gibberellic acid degradation" NARROW []
synonym: "gibberellin catabolism" EXACT []
is_a: GO:0009685 ! gibberellin metabolic process
is_a: GO:0016103 ! diterpenoid catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0045488
name: pectin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pectin, a group of galacturonic acid-containing, water-soluble colloidal carbohydrates of high molecular weight and of net negative charge." [GOC:tair_curators]
subset: gosubset_prok
synonym: "pectin metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0045489
name: pectin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [GOC:go_curators, PMID:11931668]
subset: gosubset_prok
synonym: "pectin anabolism" EXACT []
synonym: "pectin biosynthesis" EXACT []
synonym: "pectin formation" EXACT []
synonym: "pectin synthesis" EXACT []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0045488 ! pectin metabolic process

[Term]
id: GO:0045490
name: pectin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [GOC:go_curators, PMID:11931668]
subset: gosubset_prok
synonym: "pectin breakdown" EXACT []
synonym: "pectin catabolism" EXACT []
synonym: "pectin degradation" EXACT []
is_a: GO:0044247 ! cellular polysaccharide catabolic process
is_a: GO:0045488 ! pectin metabolic process

[Term]
id: GO:0045491
name: xylan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668]
subset: gosubset_prok
synonym: "xylan metabolism" EXACT []
is_a: GO:0010410 ! hemicellulose metabolic process

[Term]
id: GO:0045492
name: xylan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668]
subset: gosubset_prok
synonym: "xylan anabolism" EXACT []
synonym: "xylan biosynthesis" EXACT []
synonym: "xylan formation" EXACT []
synonym: "xylan synthesis" EXACT []
is_a: GO:0045491 ! xylan metabolic process
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process

[Term]
id: GO:0045493
name: xylan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668]
subset: gosubset_prok
synonym: "xylan breakdown" EXACT []
synonym: "xylan catabolism" EXACT []
synonym: "xylan degradation" EXACT []
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0045491 ! xylan metabolic process

[Term]
id: GO:0045494
name: photoreceptor cell maintenance
namespace: biological_process
def: "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [GOC:bf, http://cancerweb.ncl.ac.uk/]
is_a: GO:0043954 ! cellular component maintenance
relationship: part_of GO:0007601 ! visual perception

[Term]
id: GO:0045495
name: pole plasm
namespace: cellular_component
def: "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, http://cancerweb.ncl.ac.uk/]
synonym: "germ plasm" NARROW []
synonym: "polar plasm" EXACT []
is_a: GO:0005737 ! cytoplasm

[Term]
id: GO:0045496
name: male analia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318]
is_a: GO:0007487 ! analia development

[Term]
id: GO:0045497
name: female analia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318]
is_a: GO:0007487 ! analia development

[Term]
id: GO:0045498
name: sex comb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk]
is_a: GO:0007423 ! sensory organ development

[Term]
id: GO:0045499
name: chemorepellent activity
namespace: molecular_function
def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "chemorepellant activity" EXACT []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0045500
name: sevenless signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the sevenless receptor binding to one of its physiological ligands." [GOC:bf]
synonym: "sev receptor signaling pathway" EXACT []
synonym: "sev signaling pathway" EXACT []
synonym: "sevenless signalling pathway" EXACT []
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway
relationship: part_of GO:0007465 ! R7 cell fate commitment

[Term]
id: GO:0045501
name: regulation of sevenless signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators]
synonym: "regulation of sev signaling pathway" EXACT []
synonym: "regulation of sevenless signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0045676 ! regulation of R7 cell differentiation
relationship: regulates GO:0045500 ! sevenless signaling pathway

[Term]
id: GO:0045502
name: dynein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules." [GOC:bf]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045503
name: dynein light chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a light chain of the dynein complex." [GOC:bf]
is_a: GO:0045502 ! dynein binding

[Term]
id: GO:0045504
name: dynein heavy chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a heavy chain of the dynein complex." [GOC:bf]
is_a: GO:0045502 ! dynein binding

[Term]
id: GO:0045505
name: dynein intermediate chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an intermediate chain of the dynein complex." [GOC:bf]
is_a: GO:0045502 ! dynein binding

[Term]
id: GO:0045506
name: interleukin-24 receptor activity
namespace: molecular_function
def: "Combining with interleukin-24 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-24 receptor activity" EXACT [GOC:mah]
synonym: "IL-24R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0045510 ! interleukin-24 binding

[Term]
id: GO:0045507
name: interleukin-25 receptor activity
namespace: molecular_function
def: "Combining with interleukin-25 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-25 receptor activity" EXACT [GOC:mah]
synonym: "IL-25R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0045511 ! interleukin-25 binding

[Term]
id: GO:0045508
name: interleukin-26 receptor activity
namespace: molecular_function
def: "Combining with interleukin-26 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-26 receptor activity" EXACT [GOC:mah]
synonym: "IL-26R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0045512 ! interleukin-26 binding

[Term]
id: GO:0045509
name: interleukin-27 receptor activity
namespace: molecular_function
def: "Combining with interleukin-27 to initiate a change in cell activity." [GOC:jl]
synonym: "IL-27 receptor activity" EXACT [GOC:mah]
synonym: "IL-27R" EXACT []
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0045513 ! interleukin-27 binding

[Term]
id: GO:0045510
name: interleukin-24 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-24." [GOC:go_curators]
synonym: "IL-24 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0045511
name: interleukin-25 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-25." [GOC:go_curators]
synonym: "IL-25 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0045512
name: interleukin-26 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-26." [GOC:go_curators]
synonym: "IL-26 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0045513
name: interleukin-27 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-27." [GOC:go_curators]
synonym: "IL-27 binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0045514
name: interleukin-16 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-16 receptor." [GOC:go_curators]
synonym: "IL-16" NARROW []
synonym: "interleukin-16 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045515
name: interleukin-18 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-18 receptor." [GOC:go_curators]
synonym: "IL-18" NARROW []
synonym: "interleukin-18 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045516
name: interleukin-19 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-19 receptor." [GOC:go_curators]
synonym: "IL-19" NARROW []
synonym: "interleukin-19 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045517
name: interleukin-20 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-20 receptor." [GOC:go_curators]
synonym: "IL-20" NARROW []
synonym: "interleukin-20 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045518
name: interleukin-22 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-22 receptor." [GOC:go_curators]
synonym: "IL-22" NARROW []
synonym: "interleukin-22 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045519
name: interleukin-23 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-23 receptor." [GOC:go_curators]
synonym: "IL-23" NARROW []
synonym: "interleukin-23 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045520
name: interleukin-24 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-24 receptor." [GOC:go_curators]
synonym: "IL-24" NARROW []
synonym: "interleukin-24 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045521
name: interleukin-25 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-25 receptor." [GOC:go_curators]
synonym: "IL-25" NARROW []
synonym: "interleukin-25 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045522
name: interleukin-26 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-26 receptor." [GOC:go_curators]
synonym: "IL-26" NARROW []
synonym: "interleukin-26 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045523
name: interleukin-27 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-27 receptor." [GOC:go_curators]
synonym: "IL-27" NARROW []
synonym: "interleukin-27 receptor ligand" NARROW []
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0045524
name: interleukin-24 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators]
synonym: "IL-24 biosynthesis" EXACT []
synonym: "IL-24 biosynthetic process" EXACT []
synonym: "interleukin-24 anabolism" EXACT []
synonym: "interleukin-24 biosynthesis" EXACT []
synonym: "interleukin-24 formation" EXACT []
synonym: "interleukin-24 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032628 ! interleukin-24 production

[Term]
id: GO:0045525
name: interleukin-25 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators]
synonym: "IL-25 biosynthesis" EXACT []
synonym: "IL-25 biosynthetic process" EXACT []
synonym: "interleukin-25 anabolism" EXACT []
synonym: "interleukin-25 biosynthesis" EXACT []
synonym: "interleukin-25 formation" EXACT []
synonym: "interleukin-25 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032629 ! interleukin-25 production

[Term]
id: GO:0045526
name: interleukin-26 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators]
synonym: "IL-26 biosynthesis" EXACT []
synonym: "IL-26 biosynthetic process" EXACT []
synonym: "interleukin-26 anabolism" EXACT []
synonym: "interleukin-26 biosynthesis" EXACT []
synonym: "interleukin-26 formation" EXACT []
synonym: "interleukin-26 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032630 ! interleukin-26 production

[Term]
id: GO:0045527
name: interleukin-27 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators]
synonym: "IL-27 biosynthesis" EXACT []
synonym: "IL-27 biosynthetic process" EXACT []
synonym: "interleukin-27 anabolism" EXACT []
synonym: "interleukin-27 biosynthesis" EXACT []
synonym: "interleukin-27 formation" EXACT []
synonym: "interleukin-27 synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032631 ! interleukin-27 production

[Term]
id: GO:0045528
name: regulation of interleukin-24 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators]
synonym: "regulation of IL-24 biosynthesis" EXACT []
synonym: "regulation of IL-24 biosynthetic process" EXACT []
synonym: "regulation of interleukin-24 anabolism" EXACT []
synonym: "regulation of interleukin-24 biosynthesis" EXACT []
synonym: "regulation of interleukin-24 formation" EXACT []
synonym: "regulation of interleukin-24 synthesis" EXACT []
is_a: GO:0032668 ! regulation of interleukin-24 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0045524 ! interleukin-24 biosynthetic process

[Term]
id: GO:0045529
name: regulation of interleukin-25 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators]
synonym: "regulation of IL-25 biosynthesis" EXACT []
synonym: "regulation of IL-25 biosynthetic process" EXACT []
synonym: "regulation of interleukin-25 anabolism" EXACT []
synonym: "regulation of interleukin-25 biosynthesis" EXACT []
synonym: "regulation of interleukin-25 formation" EXACT []
synonym: "regulation of interleukin-25 synthesis" EXACT []
is_a: GO:0032669 ! regulation of interleukin-25 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0045525 ! interleukin-25 biosynthetic process

[Term]
id: GO:0045530
name: regulation of interleukin-26 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators]
synonym: "regulation of IL-26 biosynthesis" EXACT []
synonym: "regulation of IL-26 biosynthetic process" EXACT []
synonym: "regulation of interleukin-26 anabolism" EXACT []
synonym: "regulation of interleukin-26 biosynthesis" EXACT []
synonym: "regulation of interleukin-26 formation" EXACT []
synonym: "regulation of interleukin-26 synthesis" EXACT []
is_a: GO:0032670 ! regulation of interleukin-26 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0045526 ! interleukin-26 biosynthetic process

[Term]
id: GO:0045531
name: regulation of interleukin-27 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators]
synonym: "regulation of IL-27 biosynthesis" EXACT []
synonym: "regulation of IL-27 biosynthetic process" EXACT []
synonym: "regulation of interleukin-27 anabolism" EXACT []
synonym: "regulation of interleukin-27 biosynthesis" EXACT []
synonym: "regulation of interleukin-27 formation" EXACT []
synonym: "regulation of interleukin-27 synthesis" EXACT []
is_a: GO:0032671 ! regulation of interleukin-27 production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0045527 ! interleukin-27 biosynthetic process

[Term]
id: GO:0045532
name: negative regulation of interleukin-24 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators]
synonym: "down regulation of interleukin-24 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-24 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-24 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-24 biosynthetic process" NARROW []
synonym: "negative regulation of IL-24 biosynthesis" EXACT []
synonym: "negative regulation of IL-24 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-24 anabolism" EXACT []
synonym: "negative regulation of interleukin-24 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-24 formation" EXACT []
synonym: "negative regulation of interleukin-24 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045528 ! regulation of interleukin-24 biosynthetic process
relationship: negatively_regulates GO:0045524 ! interleukin-24 biosynthetic process

[Term]
id: GO:0045533
name: negative regulation of interleukin-25 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators]
synonym: "down regulation of interleukin-25 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-25 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-25 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-25 biosynthetic process" NARROW []
synonym: "negative regulation of IL-25 biosynthesis" EXACT []
synonym: "negative regulation of IL-25 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-25 anabolism" EXACT []
synonym: "negative regulation of interleukin-25 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-25 formation" EXACT []
synonym: "negative regulation of interleukin-25 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045529 ! regulation of interleukin-25 biosynthetic process
relationship: negatively_regulates GO:0045525 ! interleukin-25 biosynthetic process

[Term]
id: GO:0045534
name: negative regulation of interleukin-26 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators]
synonym: "down regulation of interleukin-26 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-26 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-26 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-26 biosynthetic process" NARROW []
synonym: "negative regulation of IL-26 biosynthesis" EXACT []
synonym: "negative regulation of IL-26 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-26 anabolism" EXACT []
synonym: "negative regulation of interleukin-26 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-26 formation" EXACT []
synonym: "negative regulation of interleukin-26 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045530 ! regulation of interleukin-26 biosynthetic process
relationship: negatively_regulates GO:0045526 ! interleukin-26 biosynthetic process

[Term]
id: GO:0045535
name: negative regulation of interleukin-27 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators]
synonym: "down regulation of interleukin-27 biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-27 biosynthetic process" EXACT []
synonym: "downregulation of interleukin-27 biosynthetic process" EXACT []
synonym: "inhibition of interleukin-27 biosynthetic process" NARROW []
synonym: "negative regulation of IL-27 biosynthesis" EXACT []
synonym: "negative regulation of IL-27 biosynthetic process" EXACT []
synonym: "negative regulation of interleukin-27 anabolism" EXACT []
synonym: "negative regulation of interleukin-27 biosynthesis" EXACT []
synonym: "negative regulation of interleukin-27 formation" EXACT []
synonym: "negative regulation of interleukin-27 synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045531 ! regulation of interleukin-27 biosynthetic process
relationship: negatively_regulates GO:0045527 ! interleukin-27 biosynthetic process

[Term]
id: GO:0045536
name: positive regulation of interleukin-24 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24." [GOC:go_curators]
synonym: "activation of interleukin-24 biosynthetic process" NARROW []
synonym: "positive regulation of IL-24 biosynthesis" EXACT []
synonym: "positive regulation of IL-24 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-24 anabolism" EXACT []
synonym: "positive regulation of interleukin-24 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-24 formation" EXACT []
synonym: "positive regulation of interleukin-24 synthesis" EXACT []
synonym: "stimulation of interleukin-24 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-24 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-24 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-24 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045528 ! regulation of interleukin-24 biosynthetic process
relationship: positively_regulates GO:0045524 ! interleukin-24 biosynthetic process

[Term]
id: GO:0045537
name: positive regulation of interleukin-25 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25." [GOC:go_curators]
synonym: "activation of interleukin-25 biosynthetic process" NARROW []
synonym: "positive regulation of IL-25 biosynthesis" EXACT []
synonym: "positive regulation of IL-25 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-25 anabolism" EXACT []
synonym: "positive regulation of interleukin-25 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-25 formation" EXACT []
synonym: "positive regulation of interleukin-25 synthesis" EXACT []
synonym: "stimulation of interleukin-25 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-25 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-25 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-25 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045529 ! regulation of interleukin-25 biosynthetic process
relationship: positively_regulates GO:0045525 ! interleukin-25 biosynthetic process

[Term]
id: GO:0045538
name: positive regulation of interleukin-26 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26." [GOC:go_curators]
synonym: "activation of interleukin-26 biosynthetic process" NARROW []
synonym: "positive regulation of IL-26 biosynthesis" EXACT []
synonym: "positive regulation of IL-26 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-26 anabolism" EXACT []
synonym: "positive regulation of interleukin-26 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-26 formation" EXACT []
synonym: "positive regulation of interleukin-26 synthesis" EXACT []
synonym: "stimulation of interleukin-26 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-26 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-26 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-26 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045530 ! regulation of interleukin-26 biosynthetic process
relationship: positively_regulates GO:0045526 ! interleukin-26 biosynthetic process

[Term]
id: GO:0045539
name: positive regulation of interleukin-27 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27." [GOC:go_curators]
synonym: "activation of interleukin-27 biosynthetic process" NARROW []
synonym: "positive regulation of IL-27 biosynthesis" EXACT []
synonym: "positive regulation of IL-27 biosynthetic process" EXACT []
synonym: "positive regulation of interleukin-27 anabolism" EXACT []
synonym: "positive regulation of interleukin-27 biosynthesis" EXACT []
synonym: "positive regulation of interleukin-27 formation" EXACT []
synonym: "positive regulation of interleukin-27 synthesis" EXACT []
synonym: "stimulation of interleukin-27 biosynthetic process" NARROW []
synonym: "up regulation of interleukin-27 biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-27 biosynthetic process" EXACT []
synonym: "upregulation of interleukin-27 biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045531 ! regulation of interleukin-27 biosynthetic process
relationship: positively_regulates GO:0045527 ! interleukin-27 biosynthetic process

[Term]
id: GO:0045540
name: regulation of cholesterol biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators]
synonym: "regulation of cholesterol anabolism" EXACT []
synonym: "regulation of cholesterol biosynthesis" EXACT []
synonym: "regulation of cholesterol formation" EXACT []
synonym: "regulation of cholesterol synthesis" EXACT []
is_a: GO:0050810 ! regulation of steroid biosynthetic process
is_a: GO:0090181 ! regulation of cholesterol metabolic process
relationship: regulates GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0045541
name: negative regulation of cholesterol biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators]
synonym: "down regulation of cholesterol biosynthetic process" EXACT []
synonym: "down-regulation of cholesterol biosynthetic process" EXACT []
synonym: "downregulation of cholesterol biosynthetic process" EXACT []
synonym: "inhibition of cholesterol biosynthetic process" NARROW []
synonym: "negative regulation of cholesterol anabolism" EXACT []
synonym: "negative regulation of cholesterol biosynthesis" EXACT []
synonym: "negative regulation of cholesterol formation" EXACT []
synonym: "negative regulation of cholesterol synthesis" EXACT []
is_a: GO:0045540 ! regulation of cholesterol biosynthetic process
is_a: GO:0090206 ! negative regulation of cholesterol metabolic process
relationship: negatively_regulates GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0045542
name: positive regulation of cholesterol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators]
synonym: "activation of cholesterol biosynthetic process" NARROW []
synonym: "positive regulation of cholesterol anabolism" EXACT []
synonym: "positive regulation of cholesterol biosynthesis" EXACT []
synonym: "positive regulation of cholesterol formation" EXACT []
synonym: "positive regulation of cholesterol synthesis" EXACT []
synonym: "stimulation of cholesterol biosynthetic process" NARROW []
synonym: "up regulation of cholesterol biosynthetic process" EXACT []
synonym: "up-regulation of cholesterol biosynthetic process" EXACT []
synonym: "upregulation of cholesterol biosynthetic process" EXACT []
is_a: GO:0045540 ! regulation of cholesterol biosynthetic process
is_a: GO:0090205 ! positive regulation of cholesterol metabolic process
relationship: positively_regulates GO:0006695 ! cholesterol biosynthetic process

[Term]
id: GO:0045543
name: gibberellin 2-beta-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 2-beta-hydroxygibberellin + succinate + CO2." [EC:1.14.11.13, GOC:kad]
synonym: "(gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" NARROW [EC:1.14.11.13]
synonym: "gibberellin 2-beta-hydroxylase activity" EXACT [EC:1.14.11.13]
synonym: "gibberellin 2-oxidase activity" EXACT []
synonym: "gibberellin 2beta-dioxygenase activity" EXACT [EC:1.14.11.13]
synonym: "gibberellin 2beta-hydroxylase activity" EXACT [EC:1.14.11.13]
xref: EC:1.14.11.13
xref: MetaCyc:PWY-102
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0045544
name: gibberellin 20-oxidase activity
namespace: molecular_function
def: "Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones." [PMID:7604047]
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0045545
name: syndecan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045547
name: dehydrodolichyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate." [PMID:9858571]
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0045548
name: phenylalanine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine = trans-cinnamate + NH3." [EC:4.3.1.5]
synonym: "L-phenylalanine ammonia-lyase (trans-cinnamate-forming)" EXACT [EC:4.3.1.5]
synonym: "L-phenylalanine ammonia-lyase activity" EXACT [EC:4.3.1.5]
synonym: "L-tyrosine ammonia-lyase activity" EXACT [EC:4.3.1.5]
synonym: "PAL" RELATED [EC:4.3.1.5]
synonym: "phenylalanine ammonium-lyase activity" EXACT [EC:4.3.1.5]
synonym: "phenylalanine deaminase activity" EXACT [EC:4.3.1.5]
synonym: "tyrase activity" EXACT [EC:4.3.1.5]
synonym: "tyrosine ammonia-lyase activity" EXACT [EC:4.3.1.5]
xref: EC:4.3.1.5
xref: MetaCyc:PHENYLALANINE-AMMONIA-LYASE-RXN
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0045549
name: 9-cis-epoxycarotenoid dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal and 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al." [EC:1.13.11.51]
synonym: "9-cis-epoxycarotenoid 11,12-dioxygenase activity" EXACT [EC:1.13.11.51]
synonym: "AtNCED3" RELATED [EC:1.13.11.51]
synonym: "NCED" RELATED [EC:1.13.11.51]
synonym: "neoxanthin cleavage enzyme" BROAD []
synonym: "nine-cis-epoxycarotenoid dioxygenase activity" EXACT [EC:1.13.11.51]
synonym: "PvNCED1" RELATED [EC:1.13.11.51]
synonym: "VP14" RELATED [EC:1.13.11.51]
xref: EC:1.13.11.51
is_a: GO:0010436 ! carotenoid dioxygenase activity

[Term]
id: GO:0045550
name: geranylgeranyl reductase activity
namespace: molecular_function
def: "Catalysis of the formation of phytyl moiety from the stepwise reduction of a geranylgeranyl moiety." [PMID:9492312]
subset: gosubset_prok
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0045551
name: cinnamyl-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+." [EC:1.1.1.195]
synonym: "CAD activity" BROAD [EC:1.1.1.195]
synonym: "cinnamyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.195]
synonym: "cinnamyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.195]
xref: EC:1.1.1.195
xref: MetaCyc:CINNAMYL-ALCOHOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0045552
name: dihydrokaempferol 4-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+." [EC:1.1.1.219]
subset: gosubset_prok
synonym: "cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.219]
synonym: "dihydroflavanol 4-reductase activity" EXACT [EC:1.1.1.219]
synonym: "dihydroflavonol 4-reductase activity" EXACT [EC:1.1.1.219]
synonym: "dihydromyricetin reductase activity" EXACT [EC:1.1.1.219]
synonym: "dihydroquercetin reductase activity" EXACT [EC:1.1.1.219]
synonym: "NADPH-dihydromyricetin reductase activity" EXACT [EC:1.1.1.219]
xref: EC:1.1.1.219
xref: MetaCyc:DIHYDROKAEMPFEROL-4-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0045553
name: TRAIL biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor (TNF) family of cytokines which induces apoptosis in a wide variety of cells." [PMID:9311998]
synonym: "TRAIL anabolism" EXACT []
synonym: "TRAIL biosynthesis" EXACT []
synonym: "TRAIL formation" EXACT []
synonym: "TRAIL synthesis" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032639 ! TRAIL production

[Term]
id: GO:0045554
name: regulation of TRAIL biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand." [GOC:go_curators]
synonym: "regulation of TRAIL anabolism" EXACT []
synonym: "regulation of TRAIL biosynthesis" EXACT []
synonym: "regulation of TRAIL formation" EXACT []
synonym: "regulation of TRAIL synthesis" EXACT []
is_a: GO:0032679 ! regulation of TRAIL production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0045553 ! TRAIL biosynthetic process

[Term]
id: GO:0045555
name: negative regulation of TRAIL biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand." [GOC:go_curators]
synonym: "down regulation of TRAIL biosynthetic process" EXACT []
synonym: "down-regulation of TRAIL biosynthetic process" EXACT []
synonym: "downregulation of TRAIL biosynthetic process" EXACT []
synonym: "inhibition of TRAIL biosynthetic process" NARROW []
synonym: "negative regulation of TRAIL anabolism" EXACT []
synonym: "negative regulation of TRAIL biosynthesis" EXACT []
synonym: "negative regulation of TRAIL formation" EXACT []
synonym: "negative regulation of TRAIL synthesis" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0045554 ! regulation of TRAIL biosynthetic process
relationship: negatively_regulates GO:0045553 ! TRAIL biosynthetic process

[Term]
id: GO:0045556
name: positive regulation of TRAIL biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand." [GOC:go_curators]
synonym: "activation of TRAIL biosynthetic process" NARROW []
synonym: "positive regulation of TRAIL anabolism" EXACT []
synonym: "positive regulation of TRAIL biosynthesis" EXACT []
synonym: "positive regulation of TRAIL formation" EXACT []
synonym: "positive regulation of TRAIL synthesis" EXACT []
synonym: "stimulation of TRAIL biosynthetic process" NARROW []
synonym: "up regulation of TRAIL biosynthetic process" EXACT []
synonym: "up-regulation of TRAIL biosynthetic process" EXACT []
synonym: "upregulation of TRAIL biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0045554 ! regulation of TRAIL biosynthetic process
relationship: positively_regulates GO:0045553 ! TRAIL biosynthetic process

[Term]
id: GO:0045557
name: TRAIL receptor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators]
synonym: "TRAIL receptor anabolism" EXACT []
synonym: "TRAIL receptor biosynthesis" EXACT []
synonym: "TRAIL receptor formation" EXACT []
synonym: "TRAIL receptor synthesis" EXACT []
is_a: GO:0032800 ! receptor biosynthetic process

[Term]
id: GO:0045558
name: TRAIL receptor 1 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of TRAIL-R1 (TNF-related apoptosis inducing ligand receptor 1), which engages a caspase-dependent apoptotic pathway." [GOC:go_curators, PMID:9311998]
synonym: "TRAIL receptor 1 anabolism" EXACT []
synonym: "TRAIL receptor 1 biosynthesis" EXACT []
synonym: "TRAIL receptor 1 formation" EXACT []
synonym: "TRAIL receptor 1 synthesis" EXACT []
synonym: "tumor necrosis factor receptor superfamily member 10A biosynthetic process" EXACT [PRO:000002108]
is_a: GO:0045557 ! TRAIL receptor biosynthetic process

[Term]
id: GO:0045559
name: TRAIL receptor 2 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of TRAIL-R2 (TNF-related apoptosis inducing ligand receptor 2), which engages a caspase-dependent apoptotic pathway and mediates apoptosis via the intracellular adaptor molecule FADD/MORT1." [GOC:go_curators, PMID:9311998]
synonym: "TRAIL receptor 2 anabolism" EXACT []
synonym: "TRAIL receptor 2 biosynthesis" EXACT []
synonym: "TRAIL receptor 2 formation" EXACT []
synonym: "TRAIL receptor 2 synthesis" EXACT []
synonym: "tumor necrosis factor receptor superfamily member 10B biosynthetic process" EXACT [PRO:000002109]
is_a: GO:0045557 ! TRAIL receptor biosynthetic process

[Term]
id: GO:0045560
name: regulation of TRAIL receptor biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators]
synonym: "regulation of TRAIL receptor anabolism" EXACT []
synonym: "regulation of TRAIL receptor biosynthesis" EXACT []
synonym: "regulation of TRAIL receptor formation" EXACT []
synonym: "regulation of TRAIL receptor synthesis" EXACT []
is_a: GO:0010869 ! regulation of receptor biosynthetic process
relationship: regulates GO:0045557 ! TRAIL receptor biosynthetic process

[Term]
id: GO:0045561
name: regulation of TRAIL receptor 1 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators]
synonym: "regulation of TRAIL receptor 1 anabolism" EXACT []
synonym: "regulation of TRAIL receptor 1 biosynthesis" EXACT []
synonym: "regulation of TRAIL receptor 1 formation" EXACT []
synonym: "regulation of TRAIL receptor 1 synthesis" EXACT []
is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process
relationship: regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process

[Term]
id: GO:0045562
name: regulation of TRAIL receptor 2 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators]
synonym: "regulation of TRAIL receptor 2 anabolism" EXACT []
synonym: "regulation of TRAIL receptor 2 biosynthesis" EXACT []
synonym: "regulation of TRAIL receptor 2 formation" EXACT []
synonym: "regulation of TRAIL receptor 2 synthesis" EXACT []
is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process
relationship: regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process

[Term]
id: GO:0045563
name: negative regulation of TRAIL receptor biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators]
synonym: "down regulation of TRAIL receptor biosynthetic process" EXACT []
synonym: "down-regulation of TRAIL receptor biosynthetic process" EXACT []
synonym: "downregulation of TRAIL receptor biosynthetic process" EXACT []
synonym: "inhibition of TRAIL receptor biosynthetic process" NARROW []
synonym: "negative regulation of TRAIL receptor anabolism" EXACT []
synonym: "negative regulation of TRAIL receptor biosynthesis" EXACT []
synonym: "negative regulation of TRAIL receptor formation" EXACT []
synonym: "negative regulation of TRAIL receptor synthesis" EXACT []
is_a: GO:0010871 ! negative regulation of receptor biosynthetic process
is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process
relationship: negatively_regulates GO:0045557 ! TRAIL receptor biosynthetic process

[Term]
id: GO:0045564
name: positive regulation of TRAIL receptor biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators]
synonym: "activation of TRAIL receptor biosynthetic process" NARROW []
synonym: "positive regulation of TRAIL receptor anabolism" EXACT []
synonym: "positive regulation of TRAIL receptor biosynthesis" EXACT []
synonym: "positive regulation of TRAIL receptor formation" EXACT []
synonym: "positive regulation of TRAIL receptor synthesis" EXACT []
synonym: "stimulation of TRAIL receptor biosynthetic process" NARROW []
synonym: "up regulation of TRAIL receptor biosynthetic process" EXACT []
synonym: "up-regulation of TRAIL receptor biosynthetic process" EXACT []
synonym: "upregulation of TRAIL receptor biosynthetic process" EXACT []
is_a: GO:0010870 ! positive regulation of receptor biosynthetic process
is_a: GO:0045560 ! regulation of TRAIL receptor biosynthetic process
relationship: positively_regulates GO:0045557 ! TRAIL receptor biosynthetic process

[Term]
id: GO:0045565
name: negative regulation of TRAIL receptor 1 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators]
synonym: "down regulation of TRAIL receptor 1 biosynthetic process" EXACT []
synonym: "down-regulation of TRAIL receptor 1 biosynthetic process" EXACT []
synonym: "downregulation of TRAIL receptor 1 biosynthetic process" EXACT []
synonym: "inhibition of TRAIL receptor 1 biosynthetic process" NARROW []
synonym: "negative regulation of TRAIL receptor 1 anabolism" EXACT []
synonym: "negative regulation of TRAIL receptor 1 biosynthesis" EXACT []
synonym: "negative regulation of TRAIL receptor 1 formation" EXACT []
synonym: "negative regulation of TRAIL receptor 1 synthesis" EXACT []
is_a: GO:0045561 ! regulation of TRAIL receptor 1 biosynthetic process
is_a: GO:0045563 ! negative regulation of TRAIL receptor biosynthetic process
relationship: negatively_regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process

[Term]
id: GO:0045566
name: positive regulation of TRAIL receptor 1 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators]
synonym: "activation of TRAIL receptor 1 biosynthetic process" NARROW []
synonym: "positive regulation of TRAIL receptor 1 anabolism" EXACT []
synonym: "positive regulation of TRAIL receptor 1 biosynthesis" EXACT []
synonym: "positive regulation of TRAIL receptor 1 formation" EXACT []
synonym: "positive regulation of TRAIL receptor 1 synthesis" EXACT []
synonym: "stimulation of TRAIL receptor 1 biosynthetic process" NARROW []
synonym: "up regulation of TRAIL receptor 1 biosynthetic process" EXACT []
synonym: "up-regulation of TRAIL receptor 1 biosynthetic process" EXACT []
synonym: "upregulation of TRAIL receptor 1 biosynthetic process" EXACT []
is_a: GO:0045561 ! regulation of TRAIL receptor 1 biosynthetic process
is_a: GO:0045564 ! positive regulation of TRAIL receptor biosynthetic process
relationship: positively_regulates GO:0045558 ! TRAIL receptor 1 biosynthetic process

[Term]
id: GO:0045567
name: negative regulation of TRAIL receptor 2 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators]
synonym: "down regulation of TRAIL receptor 2 biosynthetic process" EXACT []
synonym: "down-regulation of TRAIL receptor 2 biosynthetic process" EXACT []
synonym: "downregulation of TRAIL receptor 2 biosynthetic process" EXACT []
synonym: "inhibition of TRAIL receptor 2 biosynthetic process" NARROW []
synonym: "negative regulation of TRAIL receptor 2 anabolism" EXACT []
synonym: "negative regulation of TRAIL receptor 2 biosynthesis" EXACT []
synonym: "negative regulation of TRAIL receptor 2 formation" EXACT []
synonym: "negative regulation of TRAIL receptor 2 synthesis" EXACT []
is_a: GO:0045562 ! regulation of TRAIL receptor 2 biosynthetic process
is_a: GO:0045563 ! negative regulation of TRAIL receptor biosynthetic process
relationship: negatively_regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process

[Term]
id: GO:0045568
name: positive regulation of TRAIL receptor 2 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators]
synonym: "activation of TRAIL receptor 2 biosynthetic process" NARROW []
synonym: "positive regulation of TRAIL receptor 2 anabolism" EXACT []
synonym: "positive regulation of TRAIL receptor 2 biosynthesis" EXACT []
synonym: "positive regulation of TRAIL receptor 2 formation" EXACT []
synonym: "positive regulation of TRAIL receptor 2 synthesis" EXACT []
synonym: "stimulation of TRAIL receptor 2 biosynthetic process" NARROW []
synonym: "up regulation of TRAIL receptor 2 biosynthetic process" EXACT []
synonym: "up-regulation of TRAIL receptor 2 biosynthetic process" EXACT []
synonym: "upregulation of TRAIL receptor 2 biosynthetic process" EXACT []
is_a: GO:0045562 ! regulation of TRAIL receptor 2 biosynthetic process
is_a: GO:0045564 ! positive regulation of TRAIL receptor biosynthetic process
relationship: positively_regulates GO:0045559 ! TRAIL receptor 2 biosynthetic process

[Term]
id: GO:0045569
name: TRAIL binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines." [GOC:go_curators, PMID:9082980]
synonym: "Apo-2L binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0045570
name: regulation of imaginal disc growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators]
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0007446 ! imaginal disc growth

[Term]
id: GO:0045571
name: negative regulation of imaginal disc growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators]
synonym: "down regulation of imaginal disc growth" EXACT []
synonym: "down-regulation of imaginal disc growth" EXACT []
synonym: "downregulation of imaginal disc growth" EXACT []
synonym: "inhibition of imaginal disc growth" NARROW []
is_a: GO:0045570 ! regulation of imaginal disc growth
is_a: GO:0046621 ! negative regulation of organ growth
is_a: GO:0048640 ! negative regulation of developmental growth
relationship: negatively_regulates GO:0007446 ! imaginal disc growth

[Term]
id: GO:0045572
name: positive regulation of imaginal disc growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of imaginal disc growth." [GOC:go_curators]
synonym: "activation of imaginal disc growth" NARROW []
synonym: "stimulation of imaginal disc growth" NARROW []
synonym: "up regulation of imaginal disc growth" EXACT []
synonym: "up-regulation of imaginal disc growth" EXACT []
synonym: "upregulation of imaginal disc growth" EXACT []
is_a: GO:0045570 ! regulation of imaginal disc growth
is_a: GO:0046622 ! positive regulation of organ growth
is_a: GO:0048639 ! positive regulation of developmental growth
relationship: positively_regulates GO:0007446 ! imaginal disc growth

[Term]
id: GO:0045574
name: sterigmatocystin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "sterigmatocystin breakdown" EXACT []
synonym: "sterigmatocystin catabolism" EXACT []
synonym: "sterigmatocystin degradation" EXACT []
is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0045460 ! sterigmatocystin metabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0045575
name: basophil activation
namespace: biological_process
def: "The change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"]
xref: Wikipedia:Basophil_activation
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0045576
name: mast cell activation
namespace: biological_process
def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0002274 ! myeloid leukocyte activation

[Term]
id: GO:0045577
name: regulation of B cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of B cell differentiation." [GOC:go_curators]
synonym: "regulation of B lymphocyte differentiation" EXACT []
synonym: "regulation of B-cell differentiation" EXACT []
synonym: "regulation of B-lymphocyte differentiation" EXACT []
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0050864 ! regulation of B cell activation
relationship: regulates GO:0030183 ! B cell differentiation

[Term]
id: GO:0045578
name: negative regulation of B cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of B cell differentiation." [GOC:go_curators]
synonym: "down regulation of B cell differentiation" EXACT []
synonym: "down-regulation of B cell differentiation" EXACT []
synonym: "downregulation of B cell differentiation" EXACT []
synonym: "inhibition of B cell differentiation" NARROW []
synonym: "negative regulation of B lymphocyte differentiation" EXACT []
synonym: "negative regulation of B-cell differentiation" EXACT []
synonym: "negative regulation of B-lymphocyte differentiation" EXACT []
is_a: GO:0045577 ! regulation of B cell differentiation
is_a: GO:0045620 ! negative regulation of lymphocyte differentiation
is_a: GO:0050869 ! negative regulation of B cell activation
relationship: negatively_regulates GO:0030183 ! B cell differentiation

[Term]
id: GO:0045579
name: positive regulation of B cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of B cell differentiation." [GOC:go_curators]
synonym: "activation of B cell differentiation" NARROW []
synonym: "positive regulation of B lymphocyte differentiation" EXACT []
synonym: "positive regulation of B-cell differentiation" EXACT []
synonym: "positive regulation of B-lymphocyte differentiation" EXACT []
synonym: "stimulation of B cell differentiation" NARROW []
synonym: "up regulation of B cell differentiation" EXACT []
synonym: "up-regulation of B cell differentiation" EXACT []
synonym: "upregulation of B cell differentiation" EXACT []
is_a: GO:0045577 ! regulation of B cell differentiation
is_a: GO:0045621 ! positive regulation of lymphocyte differentiation
is_a: GO:0050871 ! positive regulation of B cell activation
relationship: positively_regulates GO:0030183 ! B cell differentiation

[Term]
id: GO:0045580
name: regulation of T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell differentiation." [GOC:go_curators]
synonym: "regulation of T lymphocyte differentiation" EXACT []
synonym: "regulation of T-cell differentiation" EXACT []
synonym: "regulation of T-lymphocyte differentiation" EXACT []
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0050863 ! regulation of T cell activation
relationship: regulates GO:0030217 ! T cell differentiation

[Term]
id: GO:0045581
name: negative regulation of T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell differentiation." [GOC:go_curators]
synonym: "down regulation of T cell differentiation" EXACT []
synonym: "down-regulation of T cell differentiation" EXACT []
synonym: "downregulation of T cell differentiation" EXACT []
synonym: "inhibition of T cell differentiation" NARROW []
synonym: "negative regulation of T lymphocyte differentiation" EXACT []
synonym: "negative regulation of T-cell differentiation" EXACT []
synonym: "negative regulation of T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0045620 ! negative regulation of lymphocyte differentiation
is_a: GO:0050868 ! negative regulation of T cell activation
relationship: negatively_regulates GO:0030217 ! T cell differentiation

[Term]
id: GO:0045582
name: positive regulation of T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation." [GOC:go_curators]
synonym: "activation of T cell differentiation" NARROW []
synonym: "positive regulation of T lymphocyte differentiation" EXACT []
synonym: "positive regulation of T-cell differentiation" EXACT []
synonym: "positive regulation of T-lymphocyte differentiation" EXACT []
synonym: "stimulation of T cell differentiation" NARROW []
synonym: "up regulation of T cell differentiation" EXACT []
synonym: "up-regulation of T cell differentiation" EXACT []
synonym: "upregulation of T cell differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0045621 ! positive regulation of lymphocyte differentiation
is_a: GO:0050870 ! positive regulation of T cell activation
relationship: positively_regulates GO:0030217 ! T cell differentiation

[Term]
id: GO:0045583
name: regulation of cytotoxic T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators]
synonym: "regulation of cytotoxic T lymphocyte differentiation" EXACT []
synonym: "regulation of cytotoxic T-cell differentiation" EXACT []
synonym: "regulation of cytotoxic T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
relationship: regulates GO:0045065 ! cytotoxic T cell differentiation

[Term]
id: GO:0045584
name: negative regulation of cytotoxic T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators]
synonym: "down regulation of cytotoxic T cell differentiation" EXACT []
synonym: "down-regulation of cytotoxic T cell differentiation" EXACT []
synonym: "downregulation of cytotoxic T cell differentiation" EXACT []
synonym: "inhibition of cytotoxic T cell differentiation" NARROW []
synonym: "negative regulation of cytotoxic T lymphocyte differentiation" EXACT []
synonym: "negative regulation of cytotoxic T-cell differentiation" EXACT []
synonym: "negative regulation of cytotoxic T-lymphocyte differentiation" EXACT []
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:0045583 ! regulation of cytotoxic T cell differentiation
relationship: negatively_regulates GO:0045065 ! cytotoxic T cell differentiation

[Term]
id: GO:0045585
name: positive regulation of cytotoxic T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators]
synonym: "activation of cytotoxic T cell differentiation" NARROW []
synonym: "positive regulation of cytotoxic T lymphocyte differentiation" EXACT []
synonym: "positive regulation of cytotoxic T-cell differentiation" EXACT []
synonym: "positive regulation of cytotoxic T-lymphocyte differentiation" EXACT []
synonym: "stimulation of cytotoxic T cell differentiation" NARROW []
synonym: "up regulation of cytotoxic T cell differentiation" EXACT []
synonym: "up-regulation of cytotoxic T cell differentiation" EXACT []
synonym: "upregulation of cytotoxic T cell differentiation" EXACT []
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:0045583 ! regulation of cytotoxic T cell differentiation
relationship: positively_regulates GO:0045065 ! cytotoxic T cell differentiation

[Term]
id: GO:0045586
name: regulation of gamma-delta T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators]
synonym: "regulation of gamma-delta T lymphocyte differentiation" EXACT []
synonym: "regulation of gamma-delta T-cell differentiation" EXACT []
synonym: "regulation of gamma-delta T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0046643 ! regulation of gamma-delta T cell activation
relationship: regulates GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0045587
name: negative regulation of gamma-delta T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators]
synonym: "down regulation of gamma-delta T cell differentiation" EXACT []
synonym: "down-regulation of gamma-delta T cell differentiation" EXACT []
synonym: "downregulation of gamma-delta T cell differentiation" EXACT []
synonym: "inhibition of gamma-delta T cell differentiation" NARROW []
synonym: "negative regulation of gamma-delta T lymphocyte differentiation" EXACT []
synonym: "negative regulation of gamma-delta T-cell differentiation" EXACT []
synonym: "negative regulation of gamma-delta T-lymphocyte differentiation" EXACT []
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:0045586 ! regulation of gamma-delta T cell differentiation
is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation
relationship: negatively_regulates GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0045588
name: positive regulation of gamma-delta T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators]
synonym: "activation of gamma-delta T cell differentiation" NARROW []
synonym: "positive regulation of gamma-delta T lymphocyte differentiation" EXACT []
synonym: "positive regulation of gamma-delta T-cell differentiation" EXACT []
synonym: "positive regulation of gamma-delta T-lymphocyte differentiation" EXACT []
synonym: "stimulation of gamma-delta T cell differentiation" NARROW []
synonym: "up regulation of gamma-delta T cell differentiation" EXACT []
synonym: "up-regulation of gamma-delta T cell differentiation" EXACT []
synonym: "upregulation of gamma-delta T cell differentiation" EXACT []
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:0045586 ! regulation of gamma-delta T cell differentiation
is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation
relationship: positively_regulates GO:0042492 ! gamma-delta T cell differentiation

[Term]
id: GO:0045589
name: regulation of regulatory T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "regulation of regulatory T lymphocyte differentiation" EXACT []
synonym: "regulation of regulatory T-cell differentiation" EXACT []
synonym: "regulation of regulatory T-lymphocyte differentiation" EXACT []
synonym: "regulation of suppressor T cell differentiation" EXACT []
synonym: "regulation of suppressor T lymphocyte differentiation" EXACT []
synonym: "regulation of suppressor T-cell differentiation" EXACT []
synonym: "regulation of suppressor T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
relationship: regulates GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0045590
name: negative regulation of regulatory T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of regulatory T cell differentiation" EXACT []
synonym: "down-regulation of regulatory T cell differentiation" EXACT []
synonym: "downregulation of regulatory T cell differentiation" EXACT []
synonym: "inhibition of regulatory T cell differentiation" NARROW []
synonym: "negative regulation of regulatory T lymphocyte differentiation" EXACT []
synonym: "negative regulation of regulatory T-cell differentiation" EXACT []
synonym: "negative regulation of regulatory T-lymphocyte differentiation" EXACT []
synonym: "negative regulation of suppressor T cell differentiation" EXACT []
synonym: "negative regulation of suppressor T-cell differentiation" EXACT []
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:0045589 ! regulation of regulatory T cell differentiation
relationship: negatively_regulates GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0045591
name: positive regulation of regulatory T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells." [ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of regulatory T cell differentiation" NARROW []
synonym: "positive regulation of regulatory T lymphocyte differentiation" EXACT []
synonym: "positive regulation of regulatory T-cell differentiation" EXACT []
synonym: "positive regulation of regulatory T-lymphocyte differentiation" EXACT []
synonym: "positive regulation of suppressor T cell differentiation" EXACT []
synonym: "positive regulation of suppressor T-cell differentiation" EXACT []
synonym: "stimulation of regulatory T cell differentiation" NARROW []
synonym: "up regulation of regulatory T cell differentiation" EXACT []
synonym: "up-regulation of regulatory T cell differentiation" EXACT []
synonym: "upregulation of regulatory T cell differentiation" EXACT []
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:0045589 ! regulation of regulatory T cell differentiation
relationship: positively_regulates GO:0045066 ! regulatory T cell differentiation

[Term]
id: GO:0045592
name: regulation of cumulus cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators]
synonym: "regulation of ovarian cumulus cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0001549 ! cumulus cell differentiation

[Term]
id: GO:0045593
name: negative regulation of cumulus cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators]
synonym: "down regulation of cumulus cell differentiation" EXACT []
synonym: "down-regulation of cumulus cell differentiation" EXACT []
synonym: "downregulation of cumulus cell differentiation" EXACT []
synonym: "inhibition of cumulus cell differentiation" NARROW []
synonym: "negative regulation of ovarian cumulus cell differentiation" EXACT []
is_a: GO:0045592 ! regulation of cumulus cell differentiation
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: negatively_regulates GO:0001549 ! cumulus cell differentiation

[Term]
id: GO:0045594
name: positive regulation of cumulus cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators]
synonym: "activation of cumulus cell differentiation" NARROW []
synonym: "positive regulation of ovarian cumulus cell differentiation" EXACT []
synonym: "stimulation of cumulus cell differentiation" NARROW []
synonym: "up regulation of cumulus cell differentiation" EXACT []
synonym: "up-regulation of cumulus cell differentiation" EXACT []
synonym: "upregulation of cumulus cell differentiation" EXACT []
is_a: GO:0045592 ! regulation of cumulus cell differentiation
is_a: GO:0045597 ! positive regulation of cell differentiation
relationship: positively_regulates GO:0001549 ! cumulus cell differentiation

[Term]
id: GO:0045595
name: regulation of cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0030154 ! cell differentiation

[Term]
id: GO:0045596
name: negative regulation of cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of cell differentiation" EXACT []
synonym: "down-regulation of cell differentiation" EXACT []
synonym: "downregulation of cell differentiation" EXACT []
synonym: "inhibition of cell differentiation" NARROW []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0030154 ! cell differentiation

[Term]
id: GO:0045597
name: positive regulation of cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of cell differentiation" NARROW []
synonym: "stimulation of cell differentiation" NARROW []
synonym: "up regulation of cell differentiation" EXACT []
synonym: "up-regulation of cell differentiation" EXACT []
synonym: "upregulation of cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0030154 ! cell differentiation

[Term]
id: GO:0045598
name: regulation of fat cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]
synonym: "regulation of adipocyte cell differentiation" EXACT []
synonym: "regulation of adipocyte differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0045444 ! fat cell differentiation

[Term]
id: GO:0045599
name: negative regulation of fat cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]
synonym: "down regulation of fat cell differentiation" EXACT []
synonym: "down-regulation of fat cell differentiation" EXACT []
synonym: "downregulation of fat cell differentiation" EXACT []
synonym: "inhibition of fat cell differentiation" NARROW []
synonym: "negative regulation of adipocyte cell differentiation" EXACT []
synonym: "negative regulation of adipocyte differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045598 ! regulation of fat cell differentiation
relationship: negatively_regulates GO:0045444 ! fat cell differentiation

[Term]
id: GO:0045600
name: positive regulation of fat cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators]
synonym: "activation of fat cell differentiation" NARROW []
synonym: "positive regulation of adipocyte cell differentiation" EXACT []
synonym: "positive regulation of adipocyte differentiation" EXACT []
synonym: "stimulation of fat cell differentiation" NARROW []
synonym: "up regulation of fat cell differentiation" EXACT []
synonym: "up-regulation of fat cell differentiation" EXACT []
synonym: "upregulation of fat cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045598 ! regulation of fat cell differentiation
relationship: positively_regulates GO:0045444 ! fat cell differentiation

[Term]
id: GO:0045601
name: regulation of endothelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
relationship: regulates GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0045602
name: negative regulation of endothelial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators]
synonym: "down regulation of endothelial cell differentiation" EXACT []
synonym: "down-regulation of endothelial cell differentiation" EXACT []
synonym: "downregulation of endothelial cell differentiation" EXACT []
synonym: "inhibition of endothelial cell differentiation" NARROW []
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0045601 ! regulation of endothelial cell differentiation
relationship: negatively_regulates GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0045603
name: positive regulation of endothelial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators]
synonym: "activation of endothelial cell differentiation" NARROW []
synonym: "stimulation of endothelial cell differentiation" NARROW []
synonym: "up regulation of endothelial cell differentiation" EXACT []
synonym: "up-regulation of endothelial cell differentiation" EXACT []
synonym: "upregulation of endothelial cell differentiation" EXACT []
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0045601 ! regulation of endothelial cell differentiation
relationship: positively_regulates GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0045604
name: regulation of epidermal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators]
synonym: "regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0045682 ! regulation of epidermis development
relationship: regulates GO:0009913 ! epidermal cell differentiation

[Term]
id: GO:0045605
name: negative regulation of epidermal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators]
synonym: "down regulation of epidermal cell differentiation" EXACT []
synonym: "down-regulation of epidermal cell differentiation" EXACT []
synonym: "downregulation of epidermal cell differentiation" EXACT []
synonym: "inhibition of epidermal cell differentiation" NARROW []
synonym: "negative regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045604 ! regulation of epidermal cell differentiation
is_a: GO:0045683 ! negative regulation of epidermis development
relationship: negatively_regulates GO:0009913 ! epidermal cell differentiation

[Term]
id: GO:0045606
name: positive regulation of epidermal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators]
synonym: "activation of epidermal cell differentiation" NARROW []
synonym: "positive regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk]
synonym: "stimulation of epidermal cell differentiation" NARROW []
synonym: "up regulation of epidermal cell differentiation" EXACT []
synonym: "up-regulation of epidermal cell differentiation" EXACT []
synonym: "upregulation of epidermal cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045604 ! regulation of epidermal cell differentiation
is_a: GO:0045684 ! positive regulation of epidermis development
relationship: positively_regulates GO:0009913 ! epidermal cell differentiation

[Term]
id: GO:0045607
name: regulation of auditory receptor cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators]
synonym: "regulation of auditory hair cell differentiation" EXACT []
is_a: GO:0045631 ! regulation of mechanoreceptor differentiation
relationship: regulates GO:0042491 ! auditory receptor cell differentiation

[Term]
id: GO:0045608
name: negative regulation of auditory receptor cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators]
synonym: "down regulation of auditory receptor cell differentiation" EXACT []
synonym: "down-regulation of auditory receptor cell differentiation" EXACT []
synonym: "downregulation of auditory receptor cell differentiation" EXACT []
synonym: "inhibition of auditory receptor cell differentiation" NARROW []
synonym: "negative regulation of auditory hair cell differentiation" EXACT []
is_a: GO:0045607 ! regulation of auditory receptor cell differentiation
is_a: GO:0045632 ! negative regulation of mechanoreceptor differentiation
relationship: negatively_regulates GO:0042491 ! auditory receptor cell differentiation

[Term]
id: GO:0045609
name: positive regulation of auditory receptor cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators]
synonym: "activation of auditory receptor cell differentiation" NARROW []
synonym: "positive regulation of auditory hair cell differentiation" EXACT []
synonym: "stimulation of auditory receptor cell differentiation" NARROW []
synonym: "up regulation of auditory receptor cell differentiation" EXACT []
synonym: "up-regulation of auditory receptor cell differentiation" EXACT []
synonym: "upregulation of auditory receptor cell differentiation" EXACT []
is_a: GO:0045607 ! regulation of auditory receptor cell differentiation
is_a: GO:0045633 ! positive regulation of mechanoreceptor differentiation
relationship: positively_regulates GO:0042491 ! auditory receptor cell differentiation

[Term]
id: GO:0045610
name: regulation of hemocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
synonym: "regulation of arthropod blood cell differentiation" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0045611
name: negative regulation of hemocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
synonym: "down regulation of hemocyte differentiation" EXACT []
synonym: "down-regulation of hemocyte differentiation" EXACT []
synonym: "downregulation of hemocyte differentiation" EXACT []
synonym: "inhibition of hemocyte differentiation" NARROW []
synonym: "negative regulation of arthropod blood cell differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045610 ! regulation of hemocyte differentiation
relationship: negatively_regulates GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0045612
name: positive regulation of hemocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators]
synonym: "activation of hemocyte differentiation" NARROW []
synonym: "positive regulation of arthropod blood cell differentiation" EXACT []
synonym: "stimulation of hemocyte differentiation" NARROW []
synonym: "up regulation of hemocyte differentiation" EXACT []
synonym: "up-regulation of hemocyte differentiation" EXACT []
synonym: "upregulation of hemocyte differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045610 ! regulation of hemocyte differentiation
relationship: positively_regulates GO:0042386 ! hemocyte differentiation

[Term]
id: GO:0045613
name: regulation of plasmatocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators]
is_a: GO:0045610 ! regulation of hemocyte differentiation
relationship: regulates GO:0042387 ! plasmatocyte differentiation

[Term]
id: GO:0045614
name: negative regulation of plasmatocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators]
synonym: "down regulation of plasmatocyte differentiation" EXACT []
synonym: "down-regulation of plasmatocyte differentiation" EXACT []
synonym: "downregulation of plasmatocyte differentiation" EXACT []
synonym: "inhibition of plasmatocyte differentiation" NARROW []
is_a: GO:0045611 ! negative regulation of hemocyte differentiation
is_a: GO:0045613 ! regulation of plasmatocyte differentiation
relationship: negatively_regulates GO:0042387 ! plasmatocyte differentiation

[Term]
id: GO:0045615
name: positive regulation of plasmatocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators]
synonym: "activation of plasmatocyte differentiation" NARROW []
synonym: "stimulation of plasmatocyte differentiation" NARROW []
synonym: "up regulation of plasmatocyte differentiation" EXACT []
synonym: "up-regulation of plasmatocyte differentiation" EXACT []
synonym: "upregulation of plasmatocyte differentiation" EXACT []
is_a: GO:0045612 ! positive regulation of hemocyte differentiation
is_a: GO:0045613 ! regulation of plasmatocyte differentiation
relationship: positively_regulates GO:0042387 ! plasmatocyte differentiation

[Term]
id: GO:0045616
name: regulation of keratinocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
is_a: GO:0045604 ! regulation of epidermal cell differentiation
relationship: regulates GO:0030216 ! keratinocyte differentiation

[Term]
id: GO:0045617
name: negative regulation of keratinocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators]
synonym: "down regulation of keratinocyte differentiation" EXACT []
synonym: "down-regulation of keratinocyte differentiation" EXACT []
synonym: "downregulation of keratinocyte differentiation" EXACT []
synonym: "inhibition of keratinocyte differentiation" NARROW []
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0045605 ! negative regulation of epidermal cell differentiation
is_a: GO:0045616 ! regulation of keratinocyte differentiation
relationship: negatively_regulates GO:0030216 ! keratinocyte differentiation

[Term]
id: GO:0045618
name: positive regulation of keratinocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators]
synonym: "activation of keratinocyte differentiation" NARROW []
synonym: "stimulation of keratinocyte differentiation" NARROW []
synonym: "up regulation of keratinocyte differentiation" EXACT []
synonym: "up-regulation of keratinocyte differentiation" EXACT []
synonym: "upregulation of keratinocyte differentiation" EXACT []
is_a: GO:0030858 ! positive regulation of epithelial cell differentiation
is_a: GO:0045606 ! positive regulation of epidermal cell differentiation
is_a: GO:0045616 ! regulation of keratinocyte differentiation
relationship: positively_regulates GO:0030216 ! keratinocyte differentiation

[Term]
id: GO:0045619
name: regulation of lymphocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0051249 ! regulation of lymphocyte activation
relationship: regulates GO:0030098 ! lymphocyte differentiation

[Term]
id: GO:0045620
name: negative regulation of lymphocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators]
synonym: "down regulation of lymphocyte differentiation" EXACT []
synonym: "down-regulation of lymphocyte differentiation" EXACT []
synonym: "downregulation of lymphocyte differentiation" EXACT []
synonym: "inhibition of lymphocyte differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
relationship: negatively_regulates GO:0030098 ! lymphocyte differentiation

[Term]
id: GO:0045621
name: positive regulation of lymphocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators]
synonym: "activation of lymphocyte differentiation" NARROW []
synonym: "stimulation of lymphocyte differentiation" NARROW []
synonym: "up regulation of lymphocyte differentiation" EXACT []
synonym: "up-regulation of lymphocyte differentiation" EXACT []
synonym: "upregulation of lymphocyte differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045619 ! regulation of lymphocyte differentiation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
relationship: positively_regulates GO:0030098 ! lymphocyte differentiation

[Term]
id: GO:0045622
name: regulation of T-helper cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators]
is_a: GO:0043370 ! regulation of CD4-positive, alpha beta T cell differentiation
is_a: GO:0050776 ! regulation of immune response
relationship: regulates GO:0042093 ! T-helper cell differentiation

[Term]
id: GO:0045623
name: negative regulation of T-helper cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators]
synonym: "down regulation of T-helper cell differentiation" EXACT []
synonym: "down-regulation of T-helper cell differentiation" EXACT []
synonym: "downregulation of T-helper cell differentiation" EXACT []
synonym: "inhibition of T-helper cell differentiation" NARROW []
is_a: GO:0043371 ! negative regulation of CD4-positive, alpha beta T cell differentiation
is_a: GO:0045622 ! regulation of T-helper cell differentiation
relationship: negatively_regulates GO:0042093 ! T-helper cell differentiation

[Term]
id: GO:0045624
name: positive regulation of T-helper cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators]
synonym: "activation of T-helper cell differentiation" NARROW []
synonym: "stimulation of T-helper cell differentiation" NARROW []
synonym: "up regulation of T-helper cell differentiation" EXACT []
synonym: "up-regulation of T-helper cell differentiation" EXACT []
synonym: "upregulation of T-helper cell differentiation" EXACT []
is_a: GO:0043372 ! positive regulation of CD4-positive, alpha beta T cell differentiation
is_a: GO:0045622 ! regulation of T-helper cell differentiation
relationship: positively_regulates GO:0042093 ! T-helper cell differentiation

[Term]
id: GO:0045625
name: regulation of T-helper 1 cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators]
is_a: GO:0002825 ! regulation of T-helper 1 type immune response
is_a: GO:0045622 ! regulation of T-helper cell differentiation
relationship: regulates GO:0045063 ! T-helper 1 cell differentiation

[Term]
id: GO:0045626
name: negative regulation of T-helper 1 cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators]
synonym: "down regulation of T-helper 1 cell differentiation" EXACT []
synonym: "down-regulation of T-helper 1 cell differentiation" EXACT []
synonym: "downregulation of T-helper 1 cell differentiation" EXACT []
synonym: "inhibition of T-helper 1 cell differentiation" NARROW []
is_a: GO:0045623 ! negative regulation of T-helper cell differentiation
is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation
relationship: negatively_regulates GO:0045063 ! T-helper 1 cell differentiation

[Term]
id: GO:0045627
name: positive regulation of T-helper 1 cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators]
synonym: "activation of T-helper 1 cell differentiation" NARROW []
synonym: "stimulation of T-helper 1 cell differentiation" NARROW []
synonym: "up regulation of T-helper 1 cell differentiation" EXACT []
synonym: "up-regulation of T-helper 1 cell differentiation" EXACT []
synonym: "upregulation of T-helper 1 cell differentiation" EXACT []
is_a: GO:0045624 ! positive regulation of T-helper cell differentiation
is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation
relationship: positively_regulates GO:0045063 ! T-helper 1 cell differentiation

[Term]
id: GO:0045628
name: regulation of T-helper 2 cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators]
is_a: GO:0002828 ! regulation of T-helper 2 type immune response
is_a: GO:0045622 ! regulation of T-helper cell differentiation
relationship: regulates GO:0045064 ! T-helper 2 cell differentiation

[Term]
id: GO:0045629
name: negative regulation of T-helper 2 cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators]
synonym: "down regulation of T-helper 2 cell differentiation" EXACT []
synonym: "down-regulation of T-helper 2 cell differentiation" EXACT []
synonym: "downregulation of T-helper 2 cell differentiation" EXACT []
synonym: "inhibition of T-helper 2 cell differentiation" NARROW []
is_a: GO:0045623 ! negative regulation of T-helper cell differentiation
is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation
relationship: negatively_regulates GO:0045064 ! T-helper 2 cell differentiation

[Term]
id: GO:0045630
name: positive regulation of T-helper 2 cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators]
synonym: "activation of T-helper 2 cell differentiation" NARROW []
synonym: "stimulation of T-helper 2 cell differentiation" NARROW []
synonym: "up regulation of T-helper 2 cell differentiation" EXACT []
synonym: "up-regulation of T-helper 2 cell differentiation" EXACT []
synonym: "upregulation of T-helper 2 cell differentiation" EXACT []
is_a: GO:0045624 ! positive regulation of T-helper cell differentiation
is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation
relationship: positively_regulates GO:0045064 ! T-helper 2 cell differentiation

[Term]
id: GO:0045631
name: regulation of mechanoreceptor differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators]
is_a: GO:0045664 ! regulation of neuron differentiation
relationship: regulates GO:0042490 ! mechanoreceptor differentiation

[Term]
id: GO:0045632
name: negative regulation of mechanoreceptor differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators]
synonym: "down regulation of mechanoreceptor differentiation" EXACT []
synonym: "down-regulation of mechanoreceptor differentiation" EXACT []
synonym: "downregulation of mechanoreceptor differentiation" EXACT []
synonym: "inhibition of mechanoreceptor differentiation" NARROW []
is_a: GO:0045631 ! regulation of mechanoreceptor differentiation
is_a: GO:0045665 ! negative regulation of neuron differentiation
relationship: negatively_regulates GO:0042490 ! mechanoreceptor differentiation

[Term]
id: GO:0045633
name: positive regulation of mechanoreceptor differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators]
synonym: "activation of mechanoreceptor differentiation" NARROW []
synonym: "stimulation of mechanoreceptor differentiation" NARROW []
synonym: "up regulation of mechanoreceptor differentiation" EXACT []
synonym: "up-regulation of mechanoreceptor differentiation" EXACT []
synonym: "upregulation of mechanoreceptor differentiation" EXACT []
is_a: GO:0045631 ! regulation of mechanoreceptor differentiation
is_a: GO:0045666 ! positive regulation of neuron differentiation
relationship: positively_regulates GO:0042490 ! mechanoreceptor differentiation

[Term]
id: GO:0045634
name: regulation of melanocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators]
synonym: "regulation of melanophore differentiation" EXACT []
is_a: GO:0050932 ! regulation of pigment cell differentiation
relationship: regulates GO:0030318 ! melanocyte differentiation

[Term]
id: GO:0045635
name: negative regulation of melanocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators]
synonym: "down regulation of melanocyte differentiation" EXACT []
synonym: "down-regulation of melanocyte differentiation" EXACT []
synonym: "downregulation of melanocyte differentiation" EXACT []
synonym: "inhibition of melanocyte differentiation" NARROW []
synonym: "negative regulation of melanophore differentiation" EXACT []
is_a: GO:0045634 ! regulation of melanocyte differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
relationship: negatively_regulates GO:0030318 ! melanocyte differentiation

[Term]
id: GO:0045636
name: positive regulation of melanocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators]
synonym: "activation of melanocyte differentiation" NARROW []
synonym: "positive regulation of melanophore differentiation" EXACT []
synonym: "stimulation of melanocyte differentiation" NARROW []
synonym: "up regulation of melanocyte differentiation" EXACT []
synonym: "up-regulation of melanocyte differentiation" EXACT []
synonym: "upregulation of melanocyte differentiation" EXACT []
is_a: GO:0045634 ! regulation of melanocyte differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
relationship: positively_regulates GO:0030318 ! melanocyte differentiation

[Term]
id: GO:0045637
name: regulation of myeloid cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0045638
name: negative regulation of myeloid cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators]
synonym: "down regulation of myeloid cell differentiation" EXACT []
synonym: "down-regulation of myeloid cell differentiation" EXACT []
synonym: "downregulation of myeloid cell differentiation" EXACT []
synonym: "inhibition of myeloid cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045637 ! regulation of myeloid cell differentiation
relationship: negatively_regulates GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0045639
name: positive regulation of myeloid cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators]
synonym: "activation of myeloid cell differentiation" NARROW []
synonym: "stimulation of myeloid cell differentiation" NARROW []
synonym: "up regulation of myeloid cell differentiation" EXACT []
synonym: "up-regulation of myeloid cell differentiation" EXACT []
synonym: "upregulation of myeloid cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045637 ! regulation of myeloid cell differentiation
relationship: positively_regulates GO:0030099 ! myeloid cell differentiation

[Term]
id: GO:0045640
name: regulation of basophil differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of basophil differentiation." [GOC:go_curators]
is_a: GO:0030852 ! regulation of granulocyte differentiation
relationship: regulates GO:0030221 ! basophil differentiation

[Term]
id: GO:0045641
name: negative regulation of basophil differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of basophil differentiation." [GOC:go_curators]
synonym: "down regulation of basophil differentiation" EXACT []
synonym: "down-regulation of basophil differentiation" EXACT []
synonym: "downregulation of basophil differentiation" EXACT []
synonym: "inhibition of basophil differentiation" NARROW []
is_a: GO:0030853 ! negative regulation of granulocyte differentiation
is_a: GO:0045640 ! regulation of basophil differentiation
relationship: negatively_regulates GO:0030221 ! basophil differentiation

[Term]
id: GO:0045642
name: positive regulation of basophil differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of basophil differentiation." [GOC:go_curators]
synonym: "activation of basophil differentiation" NARROW []
synonym: "stimulation of basophil differentiation" NARROW []
synonym: "up regulation of basophil differentiation" EXACT []
synonym: "up-regulation of basophil differentiation" EXACT []
synonym: "upregulation of basophil differentiation" EXACT []
is_a: GO:0030854 ! positive regulation of granulocyte differentiation
is_a: GO:0045640 ! regulation of basophil differentiation
relationship: positively_regulates GO:0030221 ! basophil differentiation

[Term]
id: GO:0045643
name: regulation of eosinophil differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators]
is_a: GO:0030852 ! regulation of granulocyte differentiation
relationship: regulates GO:0030222 ! eosinophil differentiation

[Term]
id: GO:0045644
name: negative regulation of eosinophil differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators]
synonym: "down regulation of eosinophil differentiation" EXACT []
synonym: "down-regulation of eosinophil differentiation" EXACT []
synonym: "downregulation of eosinophil differentiation" EXACT []
synonym: "inhibition of eosinophil differentiation" NARROW []
is_a: GO:0030853 ! negative regulation of granulocyte differentiation
is_a: GO:0045643 ! regulation of eosinophil differentiation
relationship: negatively_regulates GO:0030222 ! eosinophil differentiation

[Term]
id: GO:0045645
name: positive regulation of eosinophil differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators]
synonym: "activation of eosinophil differentiation" NARROW []
synonym: "stimulation of eosinophil differentiation" NARROW []
synonym: "up regulation of eosinophil differentiation" EXACT []
synonym: "up-regulation of eosinophil differentiation" EXACT []
synonym: "upregulation of eosinophil differentiation" EXACT []
is_a: GO:0030854 ! positive regulation of granulocyte differentiation
is_a: GO:0045643 ! regulation of eosinophil differentiation
relationship: positively_regulates GO:0030222 ! eosinophil differentiation

[Term]
id: GO:0045646
name: regulation of erythrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators]
synonym: "regulation of RBC differentiation" EXACT [CL:0000232]
synonym: "regulation of red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0045637 ! regulation of myeloid cell differentiation
relationship: regulates GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0045647
name: negative regulation of erythrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators]
synonym: "down regulation of erythrocyte differentiation" EXACT []
synonym: "down-regulation of erythrocyte differentiation" EXACT []
synonym: "downregulation of erythrocyte differentiation" EXACT []
synonym: "inhibition of erythrocyte differentiation" NARROW []
synonym: "negative regulation of RBC differentiation" EXACT [CL:0000232]
synonym: "negative regulation of red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
is_a: GO:0045646 ! regulation of erythrocyte differentiation
relationship: negatively_regulates GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0045648
name: positive regulation of erythrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators]
synonym: "activation of erythrocyte differentiation" NARROW []
synonym: "positive regulation of RBC differentiation" EXACT [CL:0000232]
synonym: "positive regulation of red blood cell differentiation" EXACT [CL:0000232]
synonym: "stimulation of erythrocyte differentiation" NARROW []
synonym: "up regulation of erythrocyte differentiation" EXACT []
synonym: "up-regulation of erythrocyte differentiation" EXACT []
synonym: "upregulation of erythrocyte differentiation" EXACT []
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
is_a: GO:0045646 ! regulation of erythrocyte differentiation
relationship: positively_regulates GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0045649
name: regulation of macrophage differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of macrophage differentiation." [GOC:go_curators]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
relationship: regulates GO:0030225 ! macrophage differentiation

[Term]
id: GO:0045650
name: negative regulation of macrophage differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage differentiation." [GOC:go_curators]
synonym: "down regulation of macrophage differentiation" EXACT []
synonym: "down-regulation of macrophage differentiation" EXACT []
synonym: "downregulation of macrophage differentiation" EXACT []
synonym: "inhibition of macrophage differentiation" NARROW []
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0045649 ! regulation of macrophage differentiation
relationship: negatively_regulates GO:0030225 ! macrophage differentiation

[Term]
id: GO:0045651
name: positive regulation of macrophage differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of macrophage differentiation." [GOC:go_curators]
synonym: "activation of macrophage differentiation" NARROW []
synonym: "stimulation of macrophage differentiation" NARROW []
synonym: "up regulation of macrophage differentiation" EXACT []
synonym: "up-regulation of macrophage differentiation" EXACT []
synonym: "upregulation of macrophage differentiation" EXACT []
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0045649 ! regulation of macrophage differentiation
relationship: positively_regulates GO:0030225 ! macrophage differentiation

[Term]
id: GO:0045652
name: regulation of megakaryocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators]
is_a: GO:0045637 ! regulation of myeloid cell differentiation
relationship: regulates GO:0030219 ! megakaryocyte differentiation

[Term]
id: GO:0045653
name: negative regulation of megakaryocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators]
synonym: "down regulation of megakaryocyte differentiation" EXACT []
synonym: "down-regulation of megakaryocyte differentiation" EXACT []
synonym: "downregulation of megakaryocyte differentiation" EXACT []
synonym: "inhibition of megakaryocyte differentiation" NARROW []
is_a: GO:0045638 ! negative regulation of myeloid cell differentiation
is_a: GO:0045652 ! regulation of megakaryocyte differentiation
relationship: negatively_regulates GO:0030219 ! megakaryocyte differentiation

[Term]
id: GO:0045654
name: positive regulation of megakaryocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators]
synonym: "activation of megakaryocyte differentiation" NARROW []
synonym: "stimulation of megakaryocyte differentiation" NARROW []
synonym: "up regulation of megakaryocyte differentiation" EXACT []
synonym: "up-regulation of megakaryocyte differentiation" EXACT []
synonym: "upregulation of megakaryocyte differentiation" EXACT []
is_a: GO:0045639 ! positive regulation of myeloid cell differentiation
is_a: GO:0045652 ! regulation of megakaryocyte differentiation
relationship: positively_regulates GO:0030219 ! megakaryocyte differentiation

[Term]
id: GO:0045655
name: regulation of monocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of monocyte differentiation." [GOC:go_curators]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
relationship: regulates GO:0030224 ! monocyte differentiation

[Term]
id: GO:0045656
name: negative regulation of monocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte differentiation." [GOC:go_curators]
synonym: "down regulation of monocyte differentiation" EXACT []
synonym: "down-regulation of monocyte differentiation" EXACT []
synonym: "downregulation of monocyte differentiation" EXACT []
synonym: "inhibition of monocyte differentiation" NARROW []
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0045655 ! regulation of monocyte differentiation
relationship: negatively_regulates GO:0030224 ! monocyte differentiation

[Term]
id: GO:0045657
name: positive regulation of monocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of monocyte differentiation." [GOC:go_curators]
synonym: "activation of monocyte differentiation" NARROW []
synonym: "stimulation of monocyte differentiation" NARROW []
synonym: "up regulation of monocyte differentiation" EXACT []
synonym: "up-regulation of monocyte differentiation" EXACT []
synonym: "upregulation of monocyte differentiation" EXACT []
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0045655 ! regulation of monocyte differentiation
relationship: positively_regulates GO:0030224 ! monocyte differentiation

[Term]
id: GO:0045658
name: regulation of neutrophil differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators]
is_a: GO:0030852 ! regulation of granulocyte differentiation
relationship: regulates GO:0030223 ! neutrophil differentiation

[Term]
id: GO:0045659
name: negative regulation of neutrophil differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators]
synonym: "down regulation of neutrophil differentiation" EXACT []
synonym: "down-regulation of neutrophil differentiation" EXACT []
synonym: "downregulation of neutrophil differentiation" EXACT []
synonym: "inhibition of neutrophil differentiation" NARROW []
is_a: GO:0030853 ! negative regulation of granulocyte differentiation
is_a: GO:0045658 ! regulation of neutrophil differentiation
relationship: negatively_regulates GO:0030223 ! neutrophil differentiation

[Term]
id: GO:0045660
name: positive regulation of neutrophil differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators]
synonym: "activation of neutrophil differentiation" NARROW []
synonym: "stimulation of neutrophil differentiation" NARROW []
synonym: "up regulation of neutrophil differentiation" EXACT []
synonym: "up-regulation of neutrophil differentiation" EXACT []
synonym: "upregulation of neutrophil differentiation" EXACT []
is_a: GO:0030854 ! positive regulation of granulocyte differentiation
is_a: GO:0045658 ! regulation of neutrophil differentiation
relationship: positively_regulates GO:0030223 ! neutrophil differentiation

[Term]
id: GO:0045661
name: regulation of myoblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
is_a: GO:0048742 ! regulation of skeletal muscle fiber development
is_a: GO:0051147 ! regulation of muscle cell differentiation
relationship: regulates GO:0045445 ! myoblast differentiation

[Term]
id: GO:0045662
name: negative regulation of myoblast differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
synonym: "down regulation of myoblast differentiation" EXACT []
synonym: "down-regulation of myoblast differentiation" EXACT []
synonym: "downregulation of myoblast differentiation" EXACT []
synonym: "inhibition of myoblast differentiation" NARROW []
is_a: GO:0045661 ! regulation of myoblast differentiation
is_a: GO:0051148 ! negative regulation of muscle cell differentiation
relationship: negatively_regulates GO:0045445 ! myoblast differentiation

[Term]
id: GO:0045663
name: positive regulation of myoblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
synonym: "activation of myoblast differentiation" NARROW []
synonym: "stimulation of myoblast differentiation" NARROW []
synonym: "up regulation of myoblast differentiation" EXACT []
synonym: "up-regulation of myoblast differentiation" EXACT []
synonym: "upregulation of myoblast differentiation" EXACT []
is_a: GO:0045661 ! regulation of myoblast differentiation
is_a: GO:0051149 ! positive regulation of muscle cell differentiation
relationship: positively_regulates GO:0045445 ! myoblast differentiation

[Term]
id: GO:0045664
name: regulation of neuron differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
is_a: GO:0050767 ! regulation of neurogenesis
relationship: regulates GO:0030182 ! neuron differentiation

[Term]
id: GO:0045665
name: negative regulation of neuron differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
synonym: "down regulation of neuron differentiation" EXACT []
synonym: "down-regulation of neuron differentiation" EXACT []
synonym: "downregulation of neuron differentiation" EXACT []
synonym: "inhibition of neuron differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045664 ! regulation of neuron differentiation
relationship: negatively_regulates GO:0030182 ! neuron differentiation

[Term]
id: GO:0045666
name: positive regulation of neuron differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators]
synonym: "activation of neuron differentiation" NARROW []
synonym: "stimulation of neuron differentiation" NARROW []
synonym: "up regulation of neuron differentiation" EXACT []
synonym: "up-regulation of neuron differentiation" EXACT []
synonym: "upregulation of neuron differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045664 ! regulation of neuron differentiation
relationship: positively_regulates GO:0030182 ! neuron differentiation

[Term]
id: GO:0045667
name: regulation of osteoblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators]
is_a: GO:0030278 ! regulation of ossification
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0045668
name: negative regulation of osteoblast differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators]
synonym: "down regulation of osteoblast differentiation" EXACT []
synonym: "down-regulation of osteoblast differentiation" EXACT []
synonym: "downregulation of osteoblast differentiation" EXACT []
synonym: "inhibition of osteoblast differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045667 ! regulation of osteoblast differentiation
relationship: negatively_regulates GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0045669
name: positive regulation of osteoblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators]
synonym: "activation of osteoblast differentiation" NARROW []
synonym: "stimulation of osteoblast differentiation" NARROW []
synonym: "up regulation of osteoblast differentiation" EXACT []
synonym: "up-regulation of osteoblast differentiation" EXACT []
synonym: "upregulation of osteoblast differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045667 ! regulation of osteoblast differentiation
relationship: positively_regulates GO:0001649 ! osteoblast differentiation

[Term]
id: GO:0045670
name: regulation of osteoclast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
relationship: regulates GO:0030316 ! osteoclast differentiation

[Term]
id: GO:0045671
name: negative regulation of osteoclast differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators]
synonym: "down regulation of osteoclast differentiation" EXACT []
synonym: "down-regulation of osteoclast differentiation" EXACT []
synonym: "downregulation of osteoclast differentiation" EXACT []
synonym: "inhibition of osteoclast differentiation" NARROW []
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0045670 ! regulation of osteoclast differentiation
relationship: negatively_regulates GO:0030316 ! osteoclast differentiation

[Term]
id: GO:0045672
name: positive regulation of osteoclast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators]
synonym: "activation of osteoclast differentiation" NARROW []
synonym: "stimulation of osteoclast differentiation" NARROW []
synonym: "up regulation of osteoclast differentiation" EXACT []
synonym: "up-regulation of osteoclast differentiation" EXACT []
synonym: "upregulation of osteoclast differentiation" EXACT []
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0045670 ! regulation of osteoclast differentiation
relationship: positively_regulates GO:0030316 ! osteoclast differentiation

[Term]
id: GO:0045676
name: regulation of R7 cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
relationship: regulates GO:0045466 ! R7 cell differentiation

[Term]
id: GO:0045677
name: negative regulation of R7 cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of R7cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of R7 differentiation" EXACT []
synonym: "down-regulation of R7 differentiation" EXACT []
synonym: "downregulation of R7 differentiation" EXACT []
synonym: "inhibition of R7 differentiation" NARROW []
synonym: "negative regulation of R7 differentiation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0045676 ! regulation of R7 cell differentiation
is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation
relationship: negatively_regulates GO:0045466 ! R7 cell differentiation

[Term]
id: GO:0045678
name: positive regulation of R7 cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of R7 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of R7 differentiation" NARROW []
synonym: "positive regulation of R7 differentiation" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of R7 differentiation" NARROW []
synonym: "up regulation of R7 differentiation" EXACT []
synonym: "up-regulation of R7 differentiation" EXACT []
synonym: "upregulation of R7 differentiation" EXACT []
is_a: GO:0045676 ! regulation of R7 cell differentiation
is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation
relationship: positively_regulates GO:0045466 ! R7 cell differentiation

[Term]
id: GO:0045679
name: regulation of R8 cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of R8 differentiation." [GOC:go_curators]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
relationship: regulates GO:0045465 ! R8 cell differentiation

[Term]
id: GO:0045680
name: negative regulation of R8 cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of R8 differentiation" EXACT []
synonym: "down-regulation of R8 differentiation" EXACT []
synonym: "downregulation of R8 differentiation" EXACT []
synonym: "inhibition of R8 differentiation" NARROW []
synonym: "negative regulation of R8 differentiation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0045679 ! regulation of R8 cell differentiation
is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation
relationship: negatively_regulates GO:0045465 ! R8 cell differentiation

[Term]
id: GO:0045681
name: positive regulation of R8 cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of R8 differentiation" NARROW []
synonym: "positive regulation of R8 differentiation" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of R8 differentiation" NARROW []
synonym: "up regulation of R8 differentiation" EXACT []
synonym: "up-regulation of R8 differentiation" EXACT []
synonym: "upregulation of R8 differentiation" EXACT []
is_a: GO:0045679 ! regulation of R8 cell differentiation
is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation
relationship: positively_regulates GO:0045465 ! R8 cell differentiation

[Term]
id: GO:0045682
name: regulation of epidermis development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epidermis development." [GOC:go_curators]
synonym: "regulation of epidermal development" EXACT []
synonym: "regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0008544 ! epidermis development

[Term]
id: GO:0045683
name: negative regulation of epidermis development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of epidermis development." [GOC:go_curators]
synonym: "down regulation of epidermis development" EXACT []
synonym: "down-regulation of epidermis development" EXACT []
synonym: "downregulation of epidermis development" EXACT []
synonym: "inhibition of epidermis development" NARROW []
synonym: "negative regulation of epidermal development" EXACT []
synonym: "negative regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0045682 ! regulation of epidermis development
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0008544 ! epidermis development

[Term]
id: GO:0045684
name: positive regulation of epidermis development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epidermis development." [GOC:go_curators]
synonym: "activation of epidermis development" NARROW []
synonym: "positive regulation of epidermal development" EXACT []
synonym: "positive regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk]
synonym: "stimulation of epidermis development" NARROW []
synonym: "up regulation of epidermis development" EXACT []
synonym: "up-regulation of epidermis development" EXACT []
synonym: "upregulation of epidermis development" EXACT []
is_a: GO:0045682 ! regulation of epidermis development
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0008544 ! epidermis development

[Term]
id: GO:0045685
name: regulation of glial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glia cell differentiation." [GOC:go_curators]
synonym: "regulation of glia cell differentiation" EXACT []
synonym: "regulation of neuroglia differentiation" EXACT []
is_a: GO:0014013 ! regulation of gliogenesis
relationship: regulates GO:0010001 ! glial cell differentiation

[Term]
id: GO:0045686
name: negative regulation of glial cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glia cell differentiation." [GOC:go_curators]
synonym: "down regulation of glial cell differentiation" EXACT []
synonym: "down-regulation of glial cell differentiation" EXACT []
synonym: "downregulation of glial cell differentiation" EXACT []
synonym: "inhibition of glial cell differentiation" NARROW []
synonym: "negative regulation of glia cell differentiation" EXACT []
synonym: "negative regulation of neuroglia differentiation" EXACT []
is_a: GO:0014014 ! negative regulation of gliogenesis
is_a: GO:0045685 ! regulation of glial cell differentiation
relationship: negatively_regulates GO:0010001 ! glial cell differentiation

[Term]
id: GO:0045687
name: positive regulation of glial cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glia cell differentiation." [GOC:go_curators]
synonym: "activation of glial cell differentiation" NARROW []
synonym: "positive regulation of glia cell differentiation" EXACT []
synonym: "positive regulation of neuroglia differentiation" EXACT []
synonym: "stimulation of glial cell differentiation" NARROW []
synonym: "up regulation of glial cell differentiation" EXACT []
synonym: "up-regulation of glial cell differentiation" EXACT []
synonym: "upregulation of glial cell differentiation" EXACT []
is_a: GO:0014015 ! positive regulation of gliogenesis
is_a: GO:0045685 ! regulation of glial cell differentiation
relationship: positively_regulates GO:0010001 ! glial cell differentiation

[Term]
id: GO:0045688
name: regulation of antipodal cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0009557 ! antipodal cell differentiation

[Term]
id: GO:0045689
name: negative regulation of antipodal cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "down regulation of antipodal cell differentiation" EXACT []
synonym: "down-regulation of antipodal cell differentiation" EXACT []
synonym: "downregulation of antipodal cell differentiation" EXACT []
synonym: "inhibition of antipodal cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045688 ! regulation of antipodal cell differentiation
relationship: negatively_regulates GO:0009557 ! antipodal cell differentiation

[Term]
id: GO:0045690
name: positive regulation of antipodal cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "activation of antipodal cell differentiation" NARROW []
synonym: "stimulation of antipodal cell differentiation" NARROW []
synonym: "up regulation of antipodal cell differentiation" EXACT []
synonym: "up-regulation of antipodal cell differentiation" EXACT []
synonym: "upregulation of antipodal cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045688 ! regulation of antipodal cell differentiation
relationship: positively_regulates GO:0009557 ! antipodal cell differentiation

[Term]
id: GO:0045691
name: regulation of embryo sac central cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of female gametophyte central cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "regulation of female gametophyte central cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0009559 ! embryo sac central cell differentiation

[Term]
id: GO:0045692
name: negative regulation of embryo sac central cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryo sac central cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "down regulation of female gametophyte central cell differentiation" EXACT []
synonym: "down-regulation of female gametophyte central cell differentiation" EXACT []
synonym: "downregulation of female gametophyte central cell differentiation" EXACT []
synonym: "inhibition of female gametophyte central cell differentiation" NARROW []
synonym: "negative regulation of female gametophyte central cell differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045691 ! regulation of embryo sac central cell differentiation
relationship: negatively_regulates GO:0009559 ! embryo sac central cell differentiation

[Term]
id: GO:0045693
name: positive regulation of embryo sac central cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryo sac central cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "activation of female gametophyte central cell differentiation" NARROW []
synonym: "positive regulation of female gametophyte central cell differentiation" EXACT []
synonym: "stimulation of female gametophyte central cell differentiation" NARROW []
synonym: "up regulation of female gametophyte central cell differentiation" EXACT []
synonym: "up-regulation of female gametophyte central cell differentiation" EXACT []
synonym: "upregulation of female gametophyte central cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045691 ! regulation of embryo sac central cell differentiation
relationship: positively_regulates GO:0009559 ! embryo sac central cell differentiation

[Term]
id: GO:0045694
name: regulation of embryo sac egg cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "regulation of female gametophyte egg cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0009560 ! embryo sac egg cell differentiation

[Term]
id: GO:0045695
name: negative regulation of embryo sac egg cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "down regulation of female gametophyte egg cell differentiation" EXACT []
synonym: "down-regulation of female gametophyte egg cell differentiation" EXACT []
synonym: "downregulation of female gametophyte egg cell differentiation" EXACT []
synonym: "inhibition of female gametophyte egg cell differentiation" NARROW []
synonym: "negative regulation of female gametophyte egg cell differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045694 ! regulation of embryo sac egg cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0009560 ! embryo sac egg cell differentiation

[Term]
id: GO:0045696
name: positive regulation of embryo sac egg cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant]
synonym: "activation of female gametophyte egg cell differentiation" NARROW []
synonym: "positive regulation of female gametophyte egg cell differentiation" EXACT []
synonym: "stimulation of female gametophyte egg cell differentiation" NARROW []
synonym: "up regulation of female gametophyte egg cell differentiation" EXACT []
synonym: "up-regulation of female gametophyte egg cell differentiation" EXACT []
synonym: "upregulation of female gametophyte egg cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045694 ! regulation of embryo sac egg cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0009560 ! embryo sac egg cell differentiation

[Term]
id: GO:0045697
name: regulation of synergid differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators]
synonym: "regulation of synergid cell differentiation" EXACT []
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0009563 ! synergid differentiation

[Term]
id: GO:0045698
name: negative regulation of synergid differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators]
synonym: "down regulation of synergid differentiation" EXACT []
synonym: "down-regulation of synergid differentiation" EXACT []
synonym: "downregulation of synergid differentiation" EXACT []
synonym: "inhibition of synergid differentiation" NARROW []
synonym: "negative regulation of synergid cell differentiation" EXACT []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045697 ! regulation of synergid differentiation
relationship: negatively_regulates GO:0009563 ! synergid differentiation

[Term]
id: GO:0045699
name: positive regulation of synergid differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators]
synonym: "activation of synergid differentiation" NARROW []
synonym: "positive regulation of synergid cell differentiation" EXACT []
synonym: "stimulation of synergid differentiation" NARROW []
synonym: "up regulation of synergid differentiation" EXACT []
synonym: "up-regulation of synergid differentiation" EXACT []
synonym: "upregulation of synergid differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045697 ! regulation of synergid differentiation
relationship: positively_regulates GO:0009563 ! synergid differentiation

[Term]
id: GO:0045700
name: regulation of spermatid nuclear differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators]
is_a: GO:0033043 ! regulation of organelle organization
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0045701
name: negative regulation of spermatid nuclear differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators]
synonym: "down regulation of spermatid nuclear differentiation" EXACT []
synonym: "down-regulation of spermatid nuclear differentiation" EXACT []
synonym: "downregulation of spermatid nuclear differentiation" EXACT []
synonym: "inhibition of spermatid nuclear differentiation" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0045700 ! regulation of spermatid nuclear differentiation
relationship: negatively_regulates GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0045702
name: positive regulation of spermatid nuclear differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators]
synonym: "activation of spermatid nuclear differentiation" NARROW []
synonym: "stimulation of spermatid nuclear differentiation" NARROW []
synonym: "up regulation of spermatid nuclear differentiation" EXACT []
synonym: "up-regulation of spermatid nuclear differentiation" EXACT []
synonym: "upregulation of spermatid nuclear differentiation" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0045700 ! regulation of spermatid nuclear differentiation
relationship: positively_regulates GO:0007289 ! spermatid nucleus differentiation

[Term]
id: GO:0045703
name: ketoreductase activity
namespace: molecular_function
def: "Catalysis of the reduction of a ketone group to form the corresponding alcohol." [EC:1.1.-.-]
xref: EC:1.1.-.-
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0045704
name: regulation of salivary gland boundary specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb]
synonym: "regulation of salivary gland determination" EXACT [GOC:tb]
is_a: GO:0003156 ! regulation of organ formation
relationship: regulates GO:0007432 ! salivary gland boundary specification

[Term]
id: GO:0045705
name: negative regulation of salivary gland boundary specification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb]
synonym: "down regulation of salivary gland determination" EXACT []
synonym: "down-regulation of salivary gland determination" EXACT []
synonym: "downregulation of salivary gland determination" EXACT []
synonym: "inhibition of salivary gland determination" NARROW []
synonym: "negative regulation of salivary gland determination" EXACT [GOC:tb]
is_a: GO:0045704 ! regulation of salivary gland boundary specification
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0007432 ! salivary gland boundary specification

[Term]
id: GO:0045706
name: positive regulation of salivary gland boundary specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb]
synonym: "activation of salivary gland determination" NARROW []
synonym: "positive regulation of salivary gland determination" EXACT [GOC:tb]
synonym: "stimulation of salivary gland determination" NARROW []
synonym: "up regulation of salivary gland determination" EXACT []
synonym: "up-regulation of salivary gland determination" EXACT []
synonym: "upregulation of salivary gland determination" EXACT []
is_a: GO:0045704 ! regulation of salivary gland boundary specification
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0007432 ! salivary gland boundary specification

[Term]
id: GO:0045707
name: regulation of adult salivary gland boundary specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb]
synonym: "regulation of adult salivary gland determination" EXACT [GOC:tb]
is_a: GO:0045704 ! regulation of salivary gland boundary specification
relationship: regulates GO:0007434 ! adult salivary gland boundary specification

[Term]
id: GO:0045708
name: regulation of larval salivary gland boundary specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb]
synonym: "regulation of larval salivary gland determination" EXACT [GOC:tb]
is_a: GO:0045704 ! regulation of salivary gland boundary specification
is_a: GO:0048580 ! regulation of post-embryonic development
relationship: regulates GO:0007433 ! larval salivary gland boundary specification

[Term]
id: GO:0045709
name: negative regulation of adult salivary gland boundary specification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb]
synonym: "down regulation of adult salivary gland determination" EXACT []
synonym: "down-regulation of adult salivary gland determination" EXACT []
synonym: "downregulation of adult salivary gland determination" EXACT []
synonym: "inhibition of adult salivary gland determination" NARROW []
synonym: "negative regulation of adult salivary gland determination" EXACT [GOC:tb]
is_a: GO:0045705 ! negative regulation of salivary gland boundary specification
is_a: GO:0045707 ! regulation of adult salivary gland boundary specification
relationship: negatively_regulates GO:0007434 ! adult salivary gland boundary specification

[Term]
id: GO:0045710
name: negative regulation of larval salivary gland boundary specification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb]
synonym: "down regulation of larval salivary gland determination" EXACT []
synonym: "down-regulation of larval salivary gland determination" EXACT []
synonym: "downregulation of larval salivary gland determination" EXACT []
synonym: "inhibition of larval salivary gland determination" NARROW []
synonym: "negative regulation of larval salivary gland determination" EXACT [GOC:tb]
is_a: GO:0045705 ! negative regulation of salivary gland boundary specification
is_a: GO:0045708 ! regulation of larval salivary gland boundary specification
relationship: negatively_regulates GO:0007433 ! larval salivary gland boundary specification

[Term]
id: GO:0045711
name: positive regulation of adult salivary gland boundary specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb]
synonym: "activation of adult salivary gland determination" NARROW []
synonym: "positive regulation of adult salivary gland determination" EXACT [GOC:tb]
synonym: "stimulation of adult salivary gland determination" NARROW []
synonym: "up regulation of adult salivary gland determination" EXACT []
synonym: "up-regulation of adult salivary gland determination" EXACT []
synonym: "upregulation of adult salivary gland determination" EXACT []
is_a: GO:0045706 ! positive regulation of salivary gland boundary specification
is_a: GO:0045707 ! regulation of adult salivary gland boundary specification
relationship: positively_regulates GO:0007434 ! adult salivary gland boundary specification

[Term]
id: GO:0045712
name: positive regulation of larval salivary gland boundary specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb]
synonym: "activation of larval salivary gland determination" NARROW []
synonym: "positive regulation of larval salivary gland determination" EXACT [GOC:tb]
synonym: "stimulation of larval salivary gland determination" NARROW []
synonym: "up regulation of larval salivary gland determination" EXACT []
synonym: "up-regulation of larval salivary gland determination" EXACT []
synonym: "upregulation of larval salivary gland determination" EXACT []
is_a: GO:0045706 ! positive regulation of salivary gland boundary specification
is_a: GO:0045708 ! regulation of larval salivary gland boundary specification
relationship: positively_regulates GO:0007433 ! larval salivary gland boundary specification

[Term]
id: GO:0045713
name: low-density lipoprotein receptor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors, cell surface proteins that mediate the endocytosis of low-density lipoprotein by cells." [GOC:go_curators, http://cancerweb.ncl.ac.uk/]
synonym: "LDLr biosynthesis" EXACT []
synonym: "LDLr biosynthetic process" EXACT []
synonym: "low-density lipoprotein receptor anabolism" EXACT []
synonym: "low-density lipoprotein receptor biosynthesis" EXACT []
synonym: "low-density lipoprotein receptor formation" EXACT []
synonym: "low-density lipoprotein receptor synthesis" EXACT []
is_a: GO:0032799 ! low-density lipoprotein receptor metabolic process
is_a: GO:0032800 ! receptor biosynthetic process

[Term]
id: GO:0045714
name: regulation of low-density lipoprotein receptor biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors." [GOC:go_curators]
synonym: "regulation of LDLr biosynthesis" EXACT []
synonym: "regulation of LDLr biosynthetic process" EXACT []
synonym: "regulation of low-density lipoprotein receptor anabolism" EXACT []
synonym: "regulation of low-density lipoprotein receptor biosynthesis" EXACT []
synonym: "regulation of low-density lipoprotein receptor formation" EXACT []
synonym: "regulation of low-density lipoprotein receptor synthesis" EXACT []
is_a: GO:0010869 ! regulation of receptor biosynthetic process
relationship: regulates GO:0045713 ! low-density lipoprotein receptor biosynthetic process

[Term]
id: GO:0045715
name: negative regulation of low-density lipoprotein receptor biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors." [GOC:go_curators]
synonym: "down regulation of low-density lipoprotein receptor biosynthetic process" EXACT []
synonym: "down-regulation of low-density lipoprotein receptor biosynthetic process" EXACT []
synonym: "downregulation of low-density lipoprotein receptor biosynthetic process" EXACT []
synonym: "inhibition of low-density lipoprotein receptor biosynthetic process" NARROW []
synonym: "negative regulation of low-density lipoprotein receptor anabolism" EXACT []
synonym: "negative regulation of low-density lipoprotein receptor biosynthesis" EXACT []
synonym: "negative regulation of low-density lipoprotein receptor formation" EXACT []
synonym: "negative regulation of low-density lipoprotein receptor synthesis" EXACT []
is_a: GO:0010871 ! negative regulation of receptor biosynthetic process
is_a: GO:0045714 ! regulation of low-density lipoprotein receptor biosynthetic process
relationship: negatively_regulates GO:0045713 ! low-density lipoprotein receptor biosynthetic process

[Term]
id: GO:0045716
name: positive regulation of low-density lipoprotein receptor biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors." [GOC:go_curators]
synonym: "activation of low-density lipoprotein receptor biosynthetic process" NARROW []
synonym: "positive regulation of low-density lipoprotein receptor anabolism" EXACT []
synonym: "positive regulation of low-density lipoprotein receptor biosynthesis" EXACT []
synonym: "positive regulation of low-density lipoprotein receptor formation" EXACT []
synonym: "positive regulation of low-density lipoprotein receptor synthesis" EXACT []
synonym: "stimulation of low-density lipoprotein receptor biosynthetic process" NARROW []
synonym: "up regulation of low-density lipoprotein receptor biosynthetic process" EXACT []
synonym: "up-regulation of low-density lipoprotein receptor biosynthetic process" EXACT []
synonym: "upregulation of low-density lipoprotein receptor biosynthetic process" EXACT []
is_a: GO:0010870 ! positive regulation of receptor biosynthetic process
is_a: GO:0045714 ! regulation of low-density lipoprotein receptor biosynthetic process
relationship: positively_regulates GO:0045713 ! low-density lipoprotein receptor biosynthetic process

[Term]
id: GO:0045717
name: negative regulation of fatty acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of fatty acid biosynthetic process" EXACT []
synonym: "down-regulation of fatty acid biosynthetic process" EXACT []
synonym: "downregulation of fatty acid biosynthetic process" EXACT []
synonym: "inhibition of fatty acid biosynthetic process" NARROW []
synonym: "negative regulation of fatty acid anabolism" EXACT []
synonym: "negative regulation of fatty acid biosynthesis" EXACT []
synonym: "negative regulation of fatty acid formation" EXACT []
synonym: "negative regulation of fatty acid synthesis" EXACT []
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
is_a: GO:0045922 ! negative regulation of fatty acid metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
relationship: negatively_regulates GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0045718
name: negative regulation of flagellum assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators]
synonym: "down regulation of flagellum assembly" EXACT []
synonym: "down-regulation of flagellum assembly" EXACT []
synonym: "downregulation of flagellum assembly" EXACT []
synonym: "inhibition of flagellum assembly" NARROW []
synonym: "negative regulation of flagella assembly" EXACT []
synonym: "negative regulation of flagellum biogenesis" RELATED [GOC:mah]
is_a: GO:0030092 ! regulation of flagellum assembly
is_a: GO:0031345 ! negative regulation of cell projection organization
relationship: negatively_regulates GO:0009296 ! flagellum assembly

[Term]
id: GO:0045719
name: negative regulation of glycogen biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of glycogen biosynthetic process" EXACT []
synonym: "down-regulation of glycogen biosynthetic process" EXACT []
synonym: "downregulation of glycogen biosynthetic process" EXACT []
synonym: "inhibition of glycogen biosynthetic process" NARROW []
synonym: "negative regulation of glycogen anabolism" EXACT []
synonym: "negative regulation of glycogen biosynthesis" EXACT []
synonym: "negative regulation of glycogen formation" EXACT []
synonym: "negative regulation of glycogen synthesis" EXACT []
is_a: GO:0005979 ! regulation of glycogen biosynthetic process
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0070874 ! negative regulation of glycogen metabolic process
relationship: negatively_regulates GO:0005978 ! glycogen biosynthetic process

[Term]
id: GO:0045720
name: negative regulation of integrin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators]
synonym: "down regulation of integrin biosynthetic process" EXACT []
synonym: "down-regulation of integrin biosynthetic process" EXACT []
synonym: "downregulation of integrin biosynthetic process" EXACT []
synonym: "inhibition of integrin biosynthetic process" NARROW []
synonym: "negative regulation of integrin anabolism" EXACT []
synonym: "negative regulation of integrin biosynthesis" EXACT []
synonym: "negative regulation of integrin formation" EXACT []
synonym: "negative regulation of integrin synthesis" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0045113 ! regulation of integrin biosynthetic process
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0045112 ! integrin biosynthetic process

[Term]
id: GO:0045721
name: negative regulation of gluconeogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gluconeogenesis." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of gluconeogenesis" EXACT []
synonym: "down-regulation of gluconeogenesis" EXACT []
synonym: "downregulation of gluconeogenesis" EXACT []
synonym: "inhibition of gluconeogenesis" NARROW []
is_a: GO:0006111 ! regulation of gluconeogenesis
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
relationship: negatively_regulates GO:0006094 ! gluconeogenesis

[Term]
id: GO:0045722
name: positive regulation of gluconeogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gluconeogenesis." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of gluconeogenesis" NARROW []
synonym: "stimulation of gluconeogenesis" NARROW []
synonym: "up regulation of gluconeogenesis" EXACT []
synonym: "up-regulation of gluconeogenesis" EXACT []
synonym: "upregulation of gluconeogenesis" EXACT []
is_a: GO:0006111 ! regulation of gluconeogenesis
is_a: GO:0010907 ! positive regulation of glucose metabolic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
relationship: positively_regulates GO:0006094 ! gluconeogenesis

[Term]
id: GO:0045723
name: positive regulation of fatty acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of fatty acid biosynthetic process" NARROW []
synonym: "positive regulation of fatty acid anabolism" EXACT []
synonym: "positive regulation of fatty acid biosynthesis" EXACT []
synonym: "positive regulation of fatty acid formation" EXACT []
synonym: "positive regulation of fatty acid synthesis" EXACT []
synonym: "stimulation of fatty acid biosynthetic process" NARROW []
synonym: "up regulation of fatty acid biosynthetic process" EXACT []
synonym: "up-regulation of fatty acid biosynthetic process" EXACT []
synonym: "upregulation of fatty acid biosynthetic process" EXACT []
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
is_a: GO:0045923 ! positive regulation of fatty acid metabolic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
relationship: positively_regulates GO:0006633 ! fatty acid biosynthetic process

[Term]
id: GO:0045724
name: positive regulation of flagellum assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators]
synonym: "activation of flagellum assembly" NARROW []
synonym: "positive regulation of flagella assembly" EXACT []
synonym: "positive regulation of flagellum biogenesis" RELATED [GOC:mah]
synonym: "stimulation of flagellum assembly" NARROW []
synonym: "up regulation of flagellum assembly" EXACT []
synonym: "up-regulation of flagellum assembly" EXACT []
synonym: "upregulation of flagellum assembly" EXACT []
is_a: GO:0030092 ! regulation of flagellum assembly
is_a: GO:0031346 ! positive regulation of cell projection organization
relationship: positively_regulates GO:0009296 ! flagellum assembly

[Term]
id: GO:0045725
name: positive regulation of glycogen biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of glycogen biosynthetic process" NARROW []
synonym: "positive regulation of glycogen anabolism" EXACT []
synonym: "positive regulation of glycogen biosynthesis" EXACT []
synonym: "positive regulation of glycogen formation" EXACT []
synonym: "positive regulation of glycogen synthesis" EXACT []
synonym: "stimulation of glycogen biosynthetic process" NARROW []
synonym: "up regulation of glycogen biosynthetic process" EXACT []
synonym: "up-regulation of glycogen biosynthetic process" EXACT []
synonym: "upregulation of glycogen biosynthetic process" EXACT []
is_a: GO:0005979 ! regulation of glycogen biosynthetic process
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0070875 ! positive regulation of glycogen metabolic process
relationship: positively_regulates GO:0005978 ! glycogen biosynthetic process

[Term]
id: GO:0045726
name: positive regulation of integrin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators]
synonym: "activation of integrin biosynthetic process" NARROW []
synonym: "positive regulation of integrin anabolism" EXACT []
synonym: "positive regulation of integrin biosynthesis" EXACT []
synonym: "positive regulation of integrin formation" EXACT []
synonym: "positive regulation of integrin synthesis" EXACT []
synonym: "stimulation of integrin biosynthetic process" NARROW []
synonym: "up regulation of integrin biosynthetic process" EXACT []
synonym: "up-regulation of integrin biosynthetic process" EXACT []
synonym: "upregulation of integrin biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0045113 ! regulation of integrin biosynthetic process
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0045112 ! integrin biosynthetic process

[Term]
id: GO:0045727
name: positive regulation of translation
namespace: biological_process
alt_id: GO:0045946
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:dph, GOC:go_curators, GOC:tb]
subset: gosubset_prok
synonym: "activation of protein biosynthetic process" NARROW []
synonym: "positive regulation of protein anabolism" EXACT []
synonym: "positive regulation of protein biosynthesis" EXACT []
synonym: "positive regulation of protein biosynthetic process" EXACT [GOC:tb]
synonym: "positive regulation of protein formation" EXACT []
synonym: "positive regulation of protein synthesis" EXACT []
synonym: "stimulation of protein biosynthetic process" NARROW []
synonym: "up regulation of protein biosynthetic process" EXACT []
synonym: "up-regulation of protein biosynthetic process" EXACT []
synonym: "upregulation of protein biosynthetic process" EXACT []
xref: Reactome:110506 "Activated DTOR phosphorylates DS6K"
is_a: GO:0006417 ! regulation of translation
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0032270 ! positive regulation of cellular protein metabolic process
relationship: positively_regulates GO:0006412 ! translation

[Term]
id: GO:0045728
name: respiratory burst after phagocytosis
namespace: biological_process
def: "A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "metabolic burst after phagocytosis" EXACT []
synonym: "oxidative burst after phagocytosis" EXACT []
is_a: GO:0002679 ! respiratory burst during defense response

[Term]
id: GO:0045729
name: respiratory burst at fertilization
namespace: biological_process
def: "The phase of elevated metabolic activity, during which oxygen consumption increases, that occurs at fertilization. An enhanced uptake of oxygen leads to the production of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Capacitation, a necessary prerequisite event to successful fertilization, can be induced by reactive oxygen species in vitro; hydrogen peroxide is used as an extracellular oxidant to cross-link the protective surface envelopes." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:2537493, PMID:9013127]
synonym: "metabolic burst at fertilization" EXACT []
synonym: "oxidative burst at fertilization" EXACT []
is_a: GO:0045730 ! respiratory burst
relationship: part_of GO:0007338 ! single fertilization

[Term]
id: GO:0045730
name: respiratory burst
namespace: biological_process
def: "A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "metabolic burst" EXACT []
synonym: "oxidative burst" EXACT []
xref: Wikipedia:Respiratory_burst
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0045732
name: positive regulation of protein catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of protein catabolic process" NARROW []
synonym: "positive regulation of protein breakdown" EXACT []
synonym: "positive regulation of protein catabolism" EXACT []
synonym: "positive regulation of protein degradation" EXACT []
synonym: "stimulation of protein catabolic process" NARROW []
synonym: "up regulation of protein catabolic process" EXACT []
synonym: "up-regulation of protein catabolic process" EXACT []
synonym: "upregulation of protein catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
relationship: positively_regulates GO:0030163 ! protein catabolic process

[Term]
id: GO:0045733
name: acetate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "acetate breakdown" EXACT []
synonym: "acetate catabolism" EXACT []
synonym: "acetate degradation" EXACT []
is_a: GO:0006083 ! acetate metabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0045734
name: regulation of acetate catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of acetate breakdown" EXACT []
synonym: "regulation of acetate catabolism" EXACT []
synonym: "regulation of acetate degradation" EXACT []
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
relationship: regulates GO:0045733 ! acetate catabolic process

[Term]
id: GO:0045735
name: nutrient reservoir activity
namespace: molecular_function
def: "Functions in the storage of nutritious substrates." [GOC:ai]
comment: Note that this term can be used in place of the obsolete terms 'storage protein ; GO:0005187' and 'storage protein of fat body (sensu Insecta) ; GO:0008041'.
subset: goslim_generic
subset: goslim_pir
subset: gosubset_prok
synonym: "storage protein" RELATED []
synonym: "storage protein of fat body" RELATED []
synonym: "yolk protein" RELATED []
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0045736
name: negative regulation of cyclin-dependent protein kinase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDK activity." [GOC:go_curators]
synonym: "CDK inhibitor" RELATED []
synonym: "cyclin-dependent kinase inhibitor" RELATED []
synonym: "down regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "down-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "downregulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "inhibition of cyclin-dependent protein kinase activity" NARROW []
synonym: "negative regulation of CDK activity" EXACT []
is_a: GO:0000079 ! regulation of cyclin-dependent protein kinase activity
is_a: GO:0006469 ! negative regulation of protein kinase activity
is_a: GO:0045786 ! negative regulation of cell cycle

[Term]
id: GO:0045737
name: positive regulation of cyclin-dependent protein kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of CDK activity." [GOC:go_curators]
synonym: "activation of cyclin-dependent protein kinase activity" NARROW []
synonym: "positive regulation of CDK activity" EXACT []
synonym: "stimulation of cyclin-dependent protein kinase activity" NARROW []
synonym: "up regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "up-regulation of cyclin-dependent protein kinase activity" EXACT []
synonym: "upregulation of cyclin-dependent protein kinase activity" EXACT []
is_a: GO:0000079 ! regulation of cyclin-dependent protein kinase activity
is_a: GO:0045787 ! positive regulation of cell cycle
is_a: GO:0045860 ! positive regulation of protein kinase activity

[Term]
id: GO:0045738
name: negative regulation of DNA repair
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA repair." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of DNA repair" EXACT []
synonym: "down-regulation of DNA repair" EXACT []
synonym: "downregulation of DNA repair" EXACT []
synonym: "inhibition of DNA repair" NARROW []
is_a: GO:0006282 ! regulation of DNA repair
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0051053 ! negative regulation of DNA metabolic process
relationship: negatively_regulates GO:0006281 ! DNA repair

[Term]
id: GO:0045739
name: positive regulation of DNA repair
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of DNA repair" NARROW []
synonym: "stimulation of DNA repair" NARROW []
synonym: "up regulation of DNA repair" EXACT []
synonym: "up-regulation of DNA repair" EXACT []
synonym: "upregulation of DNA repair" EXACT []
is_a: GO:0006282 ! regulation of DNA repair
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0051054 ! positive regulation of DNA metabolic process
relationship: positively_regulates GO:0006281 ! DNA repair

[Term]
id: GO:0045740
name: positive regulation of DNA replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA replication." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of DNA replication" NARROW []
synonym: "stimulation of DNA replication" NARROW []
synonym: "up regulation of DNA replication" EXACT []
synonym: "up-regulation of DNA replication" EXACT []
synonym: "upregulation of DNA replication" EXACT []
is_a: GO:0006275 ! regulation of DNA replication
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051054 ! positive regulation of DNA metabolic process
relationship: positively_regulates GO:0006260 ! DNA replication

[Term]
id: GO:0045741
name: positive regulation of epidermal growth factor receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor activity." [GOC:go_curators]
synonym: "activation of epidermal growth factor receptor activity" NARROW []
synonym: "positive regulation of EGF receptor activity" EXACT []
synonym: "positive regulation of EGFR activity" EXACT []
synonym: "stimulation of epidermal growth factor receptor activity" NARROW []
synonym: "up regulation of epidermal growth factor receptor activity" EXACT []
synonym: "up-regulation of epidermal growth factor receptor activity" EXACT []
synonym: "upregulation of epidermal growth factor receptor activity" EXACT []
is_a: GO:0007176 ! regulation of epidermal growth factor receptor activity
is_a: GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway
is_a: GO:0045860 ! positive regulation of protein kinase activity

[Term]
id: GO:0045742
name: positive regulation of epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "activation of epidermal growth factor receptor signaling pathway" NARROW []
synonym: "positive regulation of EGF receptor signaling pathway" EXACT []
synonym: "positive regulation of EGF receptor signalling pathway" EXACT []
synonym: "positive regulation of EGFR signaling pathway" EXACT []
synonym: "stimulation of epidermal growth factor receptor signaling pathway" NARROW []
synonym: "up regulation of epidermal growth factor receptor signaling pathway" EXACT []
synonym: "up-regulation of epidermal growth factor receptor signaling pathway" EXACT []
synonym: "upregulation of epidermal growth factor receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway
relationship: positively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway

[Term]
id: GO:0045743
name: positive regulation of fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]
synonym: "activation of fibroblast growth factor receptor signaling pathway" NARROW []
synonym: "positive regulation of FGF receptor signaling pathway" EXACT []
synonym: "positive regulation of FGF receptor signalling pathway" EXACT []
synonym: "positive regulation of FGFR signaling pathway" EXACT []
synonym: "stimulation of fibroblast growth factor receptor signaling pathway" NARROW []
synonym: "up regulation of fibroblast growth factor receptor signaling pathway" EXACT []
synonym: "up-regulation of fibroblast growth factor receptor signaling pathway" EXACT []
synonym: "upregulation of fibroblast growth factor receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway
relationship: positively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway

[Term]
id: GO:0045744
name: negative regulation of G-protein coupled receptor protein signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators]
synonym: "down regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "down-regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "downregulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "inhibition of G-protein coupled receptor protein signaling pathway" NARROW []
synonym: "negative regulation of G protein coupled receptor protein signaling pathway" EXACT []
synonym: "negative regulation of G protein coupled receptor protein signalling pathway" EXACT []
synonym: "negative regulation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "negative regulation of G-protein-coupled receptor protein signaling pathway" EXACT []
synonym: "negative regulation of G-protein-coupled receptor protein signalling pathway" EXACT []
synonym: "negative regulation of GPCR protein signaling pathway" EXACT []
synonym: "negative regulation of GPCR protein signalling pathway" EXACT []
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
relationship: negatively_regulates GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0045745
name: positive regulation of G-protein coupled receptor protein signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators]
synonym: "activation of G-protein coupled receptor protein signaling pathway" NARROW []
synonym: "positive regulation of G protein coupled receptor protein signaling pathway" EXACT []
synonym: "positive regulation of G protein coupled receptor protein signalling pathway" EXACT []
synonym: "positive regulation of G-protein coupled receptor protein signalling pathway" EXACT []
synonym: "positive regulation of G-protein-coupled receptor protein signaling pathway" EXACT []
synonym: "positive regulation of G-protein-coupled receptor protein signalling pathway" EXACT []
synonym: "positive regulation of GPCR protein signaling pathway" EXACT []
synonym: "positive regulation of GPCR protein signalling pathway" EXACT []
synonym: "stimulation of G-protein coupled receptor protein signaling pathway" NARROW []
synonym: "up regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "up-regulation of G-protein coupled receptor protein signaling pathway" EXACT []
synonym: "upregulation of G-protein coupled receptor protein signaling pathway" EXACT []
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
relationship: positively_regulates GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0045746
name: negative regulation of Notch signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
synonym: "down regulation of Notch signaling pathway" EXACT []
synonym: "down-regulation of Notch signaling pathway" EXACT []
synonym: "downregulation of Notch signaling pathway" EXACT []
synonym: "inhibition of Notch signaling pathway" NARROW []
synonym: "negative regulation of N signaling pathway" EXACT []
synonym: "negative regulation of N signalling pathway" EXACT []
synonym: "negative regulation of Notch signalling pathway" EXACT []
is_a: GO:0008593 ! regulation of Notch signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
relationship: negatively_regulates GO:0007219 ! Notch signaling pathway

[Term]
id: GO:0045747
name: positive regulation of Notch signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators]
synonym: "activation of Notch signaling pathway" NARROW []
synonym: "positive regulation of N signaling pathway" EXACT []
synonym: "positive regulation of N signalling pathway" EXACT []
synonym: "positive regulation of Notch signalling pathway" EXACT []
synonym: "stimulation of Notch signaling pathway" NARROW []
synonym: "up regulation of Notch signaling pathway" EXACT []
synonym: "up-regulation of Notch signaling pathway" EXACT []
synonym: "upregulation of Notch signaling pathway" EXACT []
is_a: GO:0008593 ! regulation of Notch signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
relationship: positively_regulates GO:0007219 ! Notch signaling pathway

[Term]
id: GO:0045748
name: positive regulation of R8 cell spacing in compound eye
namespace: biological_process
def: "Any process that activates or enforces the correct R8 cell spacing in a compound eye." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of R8 spacing" NARROW []
synonym: "positive regulation of R8 spacing" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of R8 spacing" NARROW []
synonym: "up regulation of R8 spacing" EXACT []
synonym: "up-regulation of R8 spacing" EXACT []
synonym: "upregulation of R8 spacing" EXACT []
is_a: GO:0045468 ! regulation of R8 cell spacing in compound eye

[Term]
id: GO:0045749
name: negative regulation of S phase of mitotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators]
synonym: "down regulation of S phase of mitotic cell cycle" EXACT []
synonym: "down-regulation of S phase of mitotic cell cycle" EXACT []
synonym: "downregulation of S phase of mitotic cell cycle" EXACT []
synonym: "inhibition of S phase of mitotic cell cycle" NARROW []
is_a: GO:0007090 ! regulation of S phase of mitotic cell cycle
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
relationship: negatively_regulates GO:0000084 ! S phase of mitotic cell cycle

[Term]
id: GO:0045750
name: positive regulation of S phase of mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators]
synonym: "activation of S phase of mitotic cell cycle" NARROW []
synonym: "stimulation of S phase of mitotic cell cycle" NARROW []
synonym: "up regulation of S phase of mitotic cell cycle" EXACT []
synonym: "up-regulation of S phase of mitotic cell cycle" EXACT []
synonym: "upregulation of S phase of mitotic cell cycle" EXACT []
is_a: GO:0007090 ! regulation of S phase of mitotic cell cycle
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0000084 ! S phase of mitotic cell cycle

[Term]
id: GO:0045751
name: negative regulation of Toll signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
synonym: "down regulation of Toll signaling pathway" EXACT []
synonym: "down-regulation of Toll signaling pathway" EXACT []
synonym: "downregulation of Toll signaling pathway" EXACT []
synonym: "inhibition of Toll signaling pathway" NARROW []
synonym: "negative regulation of Tl signaling pathway" EXACT []
synonym: "negative regulation of Tl signalling pathway" EXACT []
is_a: GO:0008592 ! regulation of Toll signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
relationship: negatively_regulates GO:0008063 ! Toll signaling pathway

[Term]
id: GO:0045752
name: positive regulation of Toll signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators]
synonym: "activation of Toll signaling pathway" NARROW []
synonym: "positive regulation of Tl signaling pathway" EXACT []
synonym: "positive regulation of Tl signalling pathway" EXACT []
synonym: "stimulation of Toll signaling pathway" NARROW []
synonym: "up regulation of Toll signaling pathway" EXACT []
synonym: "up-regulation of Toll signaling pathway" EXACT []
synonym: "upregulation of Toll signaling pathway" EXACT []
is_a: GO:0008592 ! regulation of Toll signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
relationship: positively_regulates GO:0008063 ! Toll signaling pathway

[Term]
id: GO:0045753
name: negative regulation of acetate catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of acetate catabolic process" EXACT []
synonym: "down-regulation of acetate catabolic process" EXACT []
synonym: "downregulation of acetate catabolic process" EXACT []
synonym: "inhibition of acetate catabolic process" NARROW []
synonym: "negative regulation of acetate breakdown" EXACT []
synonym: "negative regulation of acetate catabolism" EXACT []
synonym: "negative regulation of acetate degradation" EXACT []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0045734 ! regulation of acetate catabolic process
relationship: negatively_regulates GO:0045733 ! acetate catabolic process

[Term]
id: GO:0045754
name: positive regulation of acetate catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of acetate catabolic process" NARROW []
synonym: "positive regulation of acetate breakdown" EXACT []
synonym: "positive regulation of acetate catabolism" EXACT []
synonym: "positive regulation of acetate degradation" EXACT []
synonym: "stimulation of acetate catabolic process" NARROW []
synonym: "up regulation of acetate catabolic process" EXACT []
synonym: "up-regulation of acetate catabolic process" EXACT []
synonym: "upregulation of acetate catabolic process" EXACT []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0045734 ! regulation of acetate catabolic process
relationship: positively_regulates GO:0045733 ! acetate catabolic process

[Term]
id: GO:0045755
name: negative regulation of initiation of acetate catabolic process by acetate
namespace: biological_process
def: "Any process that stops or prevents the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of initiation of acetate catabolic process by acetate" EXACT []
synonym: "down-regulation of initiation of acetate catabolic process by acetate" EXACT []
synonym: "downregulation of initiation of acetate catabolic process by acetate" EXACT []
synonym: "inhibition of initiation of acetate catabolic process by acetate" NARROW []
synonym: "negative regulation of initiation of acetate breakdown by acetate" EXACT []
synonym: "negative regulation of initiation of acetate degradation by acetate" EXACT []
is_a: GO:0045147 ! regulation of initiation of acetate catabolic process by acetate
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate

[Term]
id: GO:0045756
name: positive regulation of initiation of acetate catabolic process by acetate
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of initiation of acetate catabolic process by acetate" NARROW []
synonym: "positive regulation of initiation of acetate breakdown by acetate" EXACT []
synonym: "positive regulation of initiation of acetate degradation by acetate" EXACT []
synonym: "stimulation of initiation of acetate catabolic process by acetate" NARROW []
synonym: "up regulation of initiation of acetate catabolic process by acetate" EXACT []
synonym: "up-regulation of initiation of acetate catabolic process by acetate" EXACT []
synonym: "upregulation of initiation of acetate catabolic process by acetate" EXACT []
is_a: GO:0045147 ! regulation of initiation of acetate catabolic process by acetate
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate

[Term]
id: GO:0045757
name: negative regulation of actin polymerization and/or depolymerization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of actin polymerization and/or depolymerization." [GOC:go_curators]
comment: This term was made obsolete because it has been split.
is_obsolete: true
consider: GO:0030835
consider: GO:0030837

[Term]
id: GO:0045758
name: positive regulation of actin polymerization and/or depolymerization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin polymerization and/or depolymerization." [GOC:go_curators]
comment: This term was made obsolete because it has been split.
is_obsolete: true
consider: GO:0030836
consider: GO:0030838

[Term]
id: GO:0045759
name: negative regulation of action potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of action potential creation, propagation or termination. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell." [GOC:go_curators]
synonym: "down regulation of action potential" EXACT []
synonym: "down-regulation of action potential" EXACT []
synonym: "downregulation of action potential" EXACT []
synonym: "inhibition of action potential" NARROW []
is_a: GO:0001508 ! regulation of action potential

[Term]
id: GO:0045760
name: positive regulation of action potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell." [GOC:go_curators]
synonym: "activation of action potential" NARROW []
synonym: "stimulation of action potential" NARROW []
synonym: "up regulation of action potential" EXACT []
synonym: "up-regulation of action potential" EXACT []
synonym: "upregulation of action potential" EXACT []
is_a: GO:0001508 ! regulation of action potential

[Term]
id: GO:0045761
name: regulation of adenylate cyclase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]
synonym: "adenylate cyclase regulator" RELATED []
synonym: "regulation of adenylyl cyclase activity" EXACT []
is_a: GO:0030817 ! regulation of cAMP biosynthetic process
is_a: GO:0031279 ! regulation of cyclase activity
is_a: GO:0051339 ! regulation of lyase activity

[Term]
id: GO:0045762
name: positive regulation of adenylate cyclase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators]
synonym: "adenylate cyclase activator" RELATED []
synonym: "positive regulation of adenylyl cyclase activity" EXACT []
synonym: "stimulation of adenylate cyclase activity" NARROW []
synonym: "up regulation of adenylate cyclase activity" EXACT []
synonym: "up-regulation of adenylate cyclase activity" EXACT []
synonym: "upregulation of adenylate cyclase activity" EXACT []
is_a: GO:0031281 ! positive regulation of cyclase activity
is_a: GO:0045761 ! regulation of adenylate cyclase activity
is_a: GO:0051349 ! positive regulation of lyase activity

[Term]
id: GO:0045763
name: negative regulation of cellular amino acid metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of amino acid metabolic process" EXACT []
synonym: "down-regulation of amino acid metabolic process" EXACT []
synonym: "downregulation of amino acid metabolic process" EXACT []
synonym: "inhibition of amino acid metabolic process" NARROW []
synonym: "negative regulation of amino acid metabolism" EXACT []
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
is_a: GO:0033239 ! negative regulation of cellular amine metabolic process
relationship: negatively_regulates GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0045764
name: positive regulation of cellular amino acid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of amino acid metabolic process" NARROW []
synonym: "positive regulation of amino acid metabolism" EXACT []
synonym: "stimulation of amino acid metabolic process" NARROW []
synonym: "up regulation of amino acid metabolic process" EXACT []
synonym: "up-regulation of amino acid metabolic process" EXACT []
synonym: "upregulation of amino acid metabolic process" EXACT []
is_a: GO:0006521 ! regulation of cellular amino acid metabolic process
is_a: GO:0033240 ! positive regulation of cellular amine metabolic process
relationship: positively_regulates GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0045765
name: regulation of angiogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of angiogenesis." [GOC:go_curators]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0001525 ! angiogenesis

[Term]
id: GO:0045766
name: positive regulation of angiogenesis
namespace: biological_process
def: "Any process that activates or increases angiogenesis." [GOC:go_curators]
synonym: "activation of angiogenesis" NARROW []
synonym: "stimulation of angiogenesis" NARROW []
synonym: "up regulation of angiogenesis" EXACT []
synonym: "up-regulation of angiogenesis" EXACT []
synonym: "upregulation of angiogenesis" EXACT []
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0001525 ! angiogenesis

[Term]
id: GO:0045767
name: regulation of anti-apoptosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anti-apoptosis." [GOC:go_curators]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0006916 ! anti-apoptosis

[Term]
id: GO:0045768
name: positive regulation of anti-apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anti-apoptosis." [GOC:go_curators]
synonym: "activation of anti-apoptosis" NARROW []
synonym: "stimulation of anti-apoptosis" NARROW []
synonym: "up regulation of anti-apoptosis" EXACT []
synonym: "up-regulation of anti-apoptosis" EXACT []
synonym: "upregulation of anti-apoptosis" EXACT []
is_a: GO:0045767 ! regulation of anti-apoptosis
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0006916 ! anti-apoptosis

[Term]
id: GO:0045769
name: negative regulation of asymmetric cell division
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of asymmetric cell division." [GOC:go_curators]
synonym: "down regulation of asymmetric cell division" EXACT []
synonym: "down-regulation of asymmetric cell division" EXACT []
synonym: "downregulation of asymmetric cell division" EXACT []
synonym: "inhibition of asymmetric cell division" NARROW []
is_a: GO:0009786 ! regulation of asymmetric cell division
is_a: GO:0051782 ! negative regulation of cell division
relationship: negatively_regulates GO:0008356 ! asymmetric cell division

[Term]
id: GO:0045770
name: positive regulation of asymmetric cell division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of asymmetric cell division." [GOC:go_curators]
synonym: "activation of asymmetric cell division" NARROW []
synonym: "stimulation of asymmetric cell division" NARROW []
synonym: "up regulation of asymmetric cell division" EXACT []
synonym: "up-regulation of asymmetric cell division" EXACT []
synonym: "upregulation of asymmetric cell division" EXACT []
is_a: GO:0009786 ! regulation of asymmetric cell division
is_a: GO:0051781 ! positive regulation of cell division
relationship: positively_regulates GO:0008356 ! asymmetric cell division

[Term]
id: GO:0045771
name: negative regulation of autophagic vacuole size
namespace: biological_process
def: "Any process that reduces autophagic vacuole size." [GOC:go_curators]
synonym: "down regulation of autophagic vacuole size" EXACT []
synonym: "down-regulation of autophagic vacuole size" EXACT []
synonym: "downregulation of autophagic vacuole size" EXACT []
synonym: "inhibition of autophagic vacuole size" NARROW []
is_a: GO:0016243 ! regulation of autophagic vacuole size

[Term]
id: GO:0045772
name: positive regulation of autophagic vacuole size
namespace: biological_process
def: "Any process that increases autophagic vacuole size." [GOC:go_curators]
synonym: "activation of autophagic vacuole size" NARROW []
synonym: "stimulation of autophagic vacuole size" NARROW []
synonym: "up regulation of autophagic vacuole size" EXACT []
synonym: "up-regulation of autophagic vacuole size" EXACT []
synonym: "upregulation of autophagic vacuole size" EXACT []
is_a: GO:0016243 ! regulation of autophagic vacuole size

[Term]
id: GO:0045773
name: positive regulation of axon extension
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axon extension." [GOC:go_curators]
synonym: "activation of axon extension" NARROW []
synonym: "stimulation of axon extension" NARROW []
synonym: "up regulation of axon extension" EXACT []
synonym: "up-regulation of axon extension" EXACT []
synonym: "upregulation of axon extension" EXACT []
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0030516 ! regulation of axon extension
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0050772 ! positive regulation of axonogenesis
relationship: positively_regulates GO:0048675 ! axon extension

[Term]
id: GO:0045774
name: negative regulation of beta 2 integrin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators]
synonym: "down regulation of beta 2 integrin biosynthetic process" EXACT []
synonym: "down-regulation of beta 2 integrin biosynthetic process" EXACT []
synonym: "downregulation of beta 2 integrin biosynthetic process" EXACT []
synonym: "inhibition of beta 2 integrin biosynthetic process" NARROW []
synonym: "negative regulation of beta 2 integrin anabolism" EXACT []
synonym: "negative regulation of beta 2 integrin biosynthesis" EXACT []
synonym: "negative regulation of beta 2 integrin formation" EXACT []
synonym: "negative regulation of beta 2 integrin synthesis" EXACT []
is_a: GO:0045115 ! regulation of beta 2 integrin biosynthetic process
is_a: GO:0045720 ! negative regulation of integrin biosynthetic process
relationship: negatively_regulates GO:0045114 ! beta 2 integrin biosynthetic process

[Term]
id: GO:0045775
name: positive regulation of beta 2 integrin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators]
synonym: "activation of beta 2 integrin biosynthetic process" NARROW []
synonym: "positive regulation of beta 2 integrin anabolism" EXACT []
synonym: "positive regulation of beta 2 integrin biosynthesis" EXACT []
synonym: "positive regulation of beta 2 integrin formation" EXACT []
synonym: "positive regulation of beta 2 integrin synthesis" EXACT []
synonym: "stimulation of beta 2 integrin biosynthetic process" NARROW []
synonym: "up regulation of beta 2 integrin biosynthetic process" EXACT []
synonym: "up-regulation of beta 2 integrin biosynthetic process" EXACT []
synonym: "upregulation of beta 2 integrin biosynthetic process" EXACT []
is_a: GO:0045115 ! regulation of beta 2 integrin biosynthetic process
is_a: GO:0045726 ! positive regulation of integrin biosynthetic process
relationship: positively_regulates GO:0045114 ! beta 2 integrin biosynthetic process

[Term]
id: GO:0045776
name: negative regulation of blood pressure
namespace: biological_process
def: "Any process by which the force of blood traveling through the circulatory system is decreased." [GOC:go_curators, GOC:mtg_cardio]
synonym: "down regulation of blood pressure" EXACT []
synonym: "down-regulation of blood pressure" EXACT []
synonym: "downregulation of blood pressure" EXACT []
synonym: "inhibition of blood pressure" NARROW []
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0045777
name: positive regulation of blood pressure
namespace: biological_process
def: "Any process by which the force of blood traveling through the circulatory system is increased." [GOC:go_curators, GOC:mtg_cardio]
synonym: "activation of blood pressure" NARROW []
synonym: "stimulation of blood pressure" NARROW []
synonym: "up regulation of blood pressure" EXACT []
synonym: "up-regulation of blood pressure" EXACT []
synonym: "upregulation of blood pressure" EXACT []
is_a: GO:0008217 ! regulation of blood pressure

[Term]
id: GO:0045778
name: positive regulation of ossification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone formation." [GOC:go_curators]
synonym: "activation of ossification" NARROW []
synonym: "positive regulation of bone biosynthesis" EXACT []
synonym: "positive regulation of bone formation" EXACT []
synonym: "stimulation of ossification" NARROW []
synonym: "up regulation of ossification" EXACT []
synonym: "up-regulation of ossification" EXACT []
synonym: "upregulation of ossification" EXACT []
is_a: GO:0030278 ! regulation of ossification
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0001503 ! ossification

[Term]
id: GO:0045779
name: negative regulation of bone resorption
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone resorption." [GOC:go_curators]
synonym: "down regulation of bone resorption" EXACT []
synonym: "down-regulation of bone resorption" EXACT []
synonym: "downregulation of bone resorption" EXACT []
synonym: "inhibition of bone resorption" NARROW []
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0045124 ! regulation of bone resorption
is_a: GO:0046851 ! negative regulation of bone remodeling
relationship: negatively_regulates GO:0045453 ! bone resorption

[Term]
id: GO:0045780
name: positive regulation of bone resorption
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone resorption." [GOC:go_curators]
synonym: "activation of bone resorption" NARROW []
synonym: "stimulation of bone resorption" NARROW []
synonym: "up regulation of bone resorption" EXACT []
synonym: "up-regulation of bone resorption" EXACT []
synonym: "upregulation of bone resorption" EXACT []
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0045124 ! regulation of bone resorption
is_a: GO:0046852 ! positive regulation of bone remodeling
relationship: positively_regulates GO:0045453 ! bone resorption

[Term]
id: GO:0045781
name: negative regulation of cell budding
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell budding." [GOC:go_curators]
synonym: "down regulation of cell budding" EXACT []
synonym: "down-regulation of cell budding" EXACT []
synonym: "downregulation of cell budding" EXACT []
synonym: "inhibition of cell budding" NARROW []
synonym: "negative regulation of budding" BROAD []
is_a: GO:0007116 ! regulation of cell budding
is_a: GO:0051782 ! negative regulation of cell division
relationship: negatively_regulates GO:0007114 ! cell budding

[Term]
id: GO:0045782
name: positive regulation of cell budding
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell budding." [GOC:go_curators]
synonym: "activation of cell budding" NARROW []
synonym: "positive regulation of budding" BROAD []
synonym: "stimulation of cell budding" NARROW []
synonym: "up regulation of cell budding" EXACT []
synonym: "up-regulation of cell budding" EXACT []
synonym: "upregulation of cell budding" EXACT []
is_a: GO:0007116 ! regulation of cell budding
is_a: GO:0051781 ! positive regulation of cell division
relationship: positively_regulates GO:0007114 ! cell budding

[Term]
id: GO:0045783
name: negative regulation of calcium in ER
namespace: biological_process
def: "OBSOLETE. Any process that reduces the concentration of calcium in the ER." [GOC:go_curators]
comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport').
is_obsolete: true
consider: GO:0005783
consider: GO:0006874

[Term]
id: GO:0045784
name: positive regulation of calcium in ER
namespace: biological_process
def: "OBSOLETE. Any process that increases the concentration of calcium in the ER." [GOC:go_curators]
comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport').
is_obsolete: true
consider: GO:0005783
consider: GO:0006874

[Term]
id: GO:0045785
name: positive regulation of cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell adhesion." [GOC:go_curators]
synonym: "activation of cell adhesion" NARROW []
synonym: "stimulation of cell adhesion" NARROW []
synonym: "up regulation of cell adhesion" EXACT []
synonym: "up-regulation of cell adhesion" EXACT []
synonym: "upregulation of cell adhesion" EXACT []
is_a: GO:0030155 ! regulation of cell adhesion
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0007155 ! cell adhesion

[Term]
id: GO:0045786
name: negative regulation of cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through cell cycle" EXACT []
synonym: "down-regulation of progression through cell cycle" EXACT []
synonym: "downregulation of progression through cell cycle" EXACT []
synonym: "inhibition of progression through cell cycle" NARROW []
synonym: "negative regulation of cell cycle progression" EXACT []
synonym: "negative regulation of progression through cell cycle" EXACT []
xref: Reactome:193670 "p75NTR negatively regulates cell cycle via SC1"
xref: Reactome:449258 "p75NTR negatively regulates cell cycle via SC1"
xref: Reactome:470377 "p75NTR negatively regulates cell cycle via SC1"
xref: Reactome:488058 "p75NTR negatively regulates cell cycle via SC1"
xref: Reactome:508016 "p75NTR negatively regulates cell cycle via SC1"
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051726 ! regulation of cell cycle
relationship: negatively_regulates GO:0007049 ! cell cycle

[Term]
id: GO:0045787
name: positive regulation of cell cycle
namespace: biological_process
def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators]
synonym: "activation of progression through cell cycle" NARROW []
synonym: "positive regulation of cell cycle progression" EXACT []
synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through cell cycle" NARROW []
synonym: "up regulation of progression through cell cycle" EXACT []
synonym: "up-regulation of progression through cell cycle" EXACT []
synonym: "upregulation of progression through cell cycle" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051726 ! regulation of cell cycle
relationship: positively_regulates GO:0007049 ! cell cycle

[Term]
id: GO:0045792
name: negative regulation of cell size
namespace: biological_process
def: "Any process that reduces cell size." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of cell size" EXACT []
synonym: "down-regulation of cell size" EXACT []
synonym: "downregulation of cell size" EXACT []
synonym: "inhibition of cell size" NARROW []
is_a: GO:0008361 ! regulation of cell size

[Term]
id: GO:0045793
name: positive regulation of cell size
namespace: biological_process
def: "Any process that increases cell size." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of cell size" NARROW []
synonym: "stimulation of cell size" NARROW []
synonym: "up regulation of cell size" EXACT []
synonym: "up-regulation of cell size" EXACT []
synonym: "upregulation of cell size" EXACT []
xref: Reactome:110468 "Activation of DAkt1 by DPDK1"
is_a: GO:0008361 ! regulation of cell size

[Term]
id: GO:0045794
name: negative regulation of cell volume
namespace: biological_process
def: "Any process that decreases cell volume." [GOC:go_curators]
synonym: "cell regulatory volume decrease" RELATED [PMID:12388065]
synonym: "RVD" RELATED [PMID:12388065]
is_a: GO:0006884 ! cell volume homeostasis

[Term]
id: GO:0045795
name: positive regulation of cell volume
namespace: biological_process
def: "Any process that increases cell volume." [GOC:go_curators]
is_a: GO:0006884 ! cell volume homeostasis

[Term]
id: GO:0045796
name: negative regulation of intestinal cholesterol absorption
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine." [GOC:go_curators]
synonym: "down regulation of cholesterol absorption" EXACT []
synonym: "down-regulation of cholesterol absorption" EXACT []
synonym: "downregulation of cholesterol absorption" EXACT []
synonym: "inhibition of cholesterol absorption" NARROW []
is_a: GO:0030300 ! regulation of intestinal cholesterol absorption
is_a: GO:0032375 ! negative regulation of cholesterol transport
is_a: GO:0060457 ! negative regulation of digestive system process
relationship: negatively_regulates GO:0030299 ! intestinal cholesterol absorption

[Term]
id: GO:0045797
name: positive regulation of intestinal cholesterol absorption
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine." [GOC:go_curators]
synonym: "activation of cholesterol absorption" NARROW []
synonym: "stimulation of cholesterol absorption" NARROW []
synonym: "up regulation of cholesterol absorption" EXACT []
synonym: "up-regulation of cholesterol absorption" EXACT []
synonym: "upregulation of cholesterol absorption" EXACT []
is_a: GO:0030300 ! regulation of intestinal cholesterol absorption
is_a: GO:0032376 ! positive regulation of cholesterol transport
is_a: GO:0060456 ! positive regulation of digestive system process
relationship: positively_regulates GO:0030299 ! intestinal cholesterol absorption

[Term]
id: GO:0045798
name: negative regulation of chromatin assembly or disassembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators]
synonym: "down regulation of chromatin assembly or disassembly" EXACT []
synonym: "down-regulation of chromatin assembly or disassembly" EXACT []
synonym: "downregulation of chromatin assembly or disassembly" EXACT []
synonym: "inhibition of chromatin assembly or disassembly" NARROW []
synonym: "negative regulation of chromatin assembly/disassembly" EXACT []
is_a: GO:0001672 ! regulation of chromatin assembly or disassembly
is_a: GO:0010639 ! negative regulation of organelle organization
relationship: negatively_regulates GO:0006333 ! chromatin assembly or disassembly

[Term]
id: GO:0045799
name: positive regulation of chromatin assembly or disassembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators]
synonym: "activation of chromatin assembly or disassembly" NARROW []
synonym: "positive regulation of chromatin assembly/disassembly" EXACT []
synonym: "stimulation of chromatin assembly or disassembly" NARROW []
synonym: "up regulation of chromatin assembly or disassembly" EXACT []
synonym: "up-regulation of chromatin assembly or disassembly" EXACT []
synonym: "upregulation of chromatin assembly or disassembly" EXACT []
is_a: GO:0001672 ! regulation of chromatin assembly or disassembly
is_a: GO:0010638 ! positive regulation of organelle organization
relationship: positively_regulates GO:0006333 ! chromatin assembly or disassembly

[Term]
id: GO:0045800
name: negative regulation of chitin-based cuticle tanning
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jic, GOC:mtg_sensu]
synonym: "down regulation of cuticle tanning" EXACT []
synonym: "down-regulation of cuticle tanning" EXACT []
synonym: "downregulation of cuticle tanning" EXACT []
synonym: "inhibition of cuticle tanning" NARROW []
synonym: "negative regulation of cuticle hardening" NARROW []
synonym: "negative regulation of cuticle tanning" EXACT []
is_a: GO:0007564 ! regulation of chitin-based cuticle tanning
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0007593 ! chitin-based cuticle tanning

[Term]
id: GO:0045801
name: positive regulation of chitin-based cuticle tanning
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jic, GOC:mtg_sensu]
synonym: "activation of cuticle tanning" NARROW []
synonym: "positive regulation of cuticle hardening" NARROW []
synonym: "positive regulation of cuticle tanning" EXACT []
synonym: "stimulation of cuticle tanning" NARROW []
synonym: "up regulation of cuticle tanning" EXACT []
synonym: "up-regulation of cuticle tanning" EXACT []
synonym: "upregulation of cuticle tanning" EXACT []
is_a: GO:0007564 ! regulation of chitin-based cuticle tanning
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0007593 ! chitin-based cuticle tanning

[Term]
id: GO:0045802
name: negative regulation of cytoskeleton
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators]
comment: This term was made obsolete because cytoskeleton is not a process, so the term made no sense.
is_obsolete: true
consider: GO:0007010

[Term]
id: GO:0045803
name: positive regulation of cytoskeleton
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators]
comment: This term was made obsolete because cytoskeleton is not a process, so the term made no sense.
is_obsolete: true
consider: GO:0007010

[Term]
id: GO:0045804
name: negative regulation of eclosion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of eclosion." [GOC:go_curators]
synonym: "down regulation of eclosion" EXACT []
synonym: "down-regulation of eclosion" EXACT []
synonym: "downregulation of eclosion" EXACT []
synonym: "inhibition of eclosion" NARROW []
is_a: GO:0007563 ! regulation of eclosion
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0007562 ! eclosion

[Term]
id: GO:0045805
name: positive regulation of eclosion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of eclosion." [GOC:go_curators]
synonym: "activation of eclosion" NARROW []
synonym: "stimulation of eclosion" NARROW []
synonym: "up regulation of eclosion" EXACT []
synonym: "up-regulation of eclosion" EXACT []
synonym: "upregulation of eclosion" EXACT []
is_a: GO:0007563 ! regulation of eclosion
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0007562 ! eclosion

[Term]
id: GO:0045806
name: negative regulation of endocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocytosis." [GOC:go_curators]
synonym: "down regulation of endocytosis" EXACT []
synonym: "down-regulation of endocytosis" EXACT []
synonym: "downregulation of endocytosis" EXACT []
synonym: "inhibition of endocytosis" NARROW []
is_a: GO:0030100 ! regulation of endocytosis
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051129 ! negative regulation of cellular component organization
relationship: negatively_regulates GO:0006897 ! endocytosis

[Term]
id: GO:0045807
name: positive regulation of endocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators]
synonym: "activation of endocytosis" NARROW []
synonym: "stimulation of endocytosis" NARROW []
synonym: "up regulation of endocytosis" EXACT []
synonym: "up-regulation of endocytosis" EXACT []
synonym: "upregulation of endocytosis" EXACT []
is_a: GO:0030100 ! regulation of endocytosis
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0006897 ! endocytosis

[Term]
id: GO:0045808
name: negative regulation of establishment of competence for transformation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of competence for transformation." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of establishment of competence for transformation" EXACT []
synonym: "down-regulation of establishment of competence for transformation" EXACT []
synonym: "downregulation of establishment of competence for transformation" EXACT []
synonym: "inhibition of establishment of competence for transformation" NARROW []
synonym: "inhibitor of the establishment of competence for transformation activity" RELATED []
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0032105 ! negative regulation of response to extracellular stimulus
is_a: GO:0045304 ! regulation of establishment of competence for transformation
relationship: negatively_regulates GO:0030420 ! establishment of competence for transformation

[Term]
id: GO:0045809
name: positive regulation of establishment of competence for transformation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of competence for transformation." [GOC:go_curators]
synonym: "activation of establishment of competence for transformation" NARROW []
synonym: "activator of the establishment of competence for transformation activity" RELATED []
synonym: "stimulation of establishment of competence for transformation" NARROW []
synonym: "up regulation of establishment of competence for transformation" EXACT []
synonym: "up-regulation of establishment of competence for transformation" EXACT []
synonym: "upregulation of establishment of competence for transformation" EXACT []
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0032106 ! positive regulation of response to extracellular stimulus
is_a: GO:0045304 ! regulation of establishment of competence for transformation
relationship: positively_regulates GO:0030420 ! establishment of competence for transformation

[Term]
id: GO:0045812
name: negative regulation of Wnt receptor signaling pathway, calcium modulating pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of frizzled-2 signaling pathway" EXACT []
synonym: "down-regulation of frizzled-2 signaling pathway" EXACT []
synonym: "downregulation of frizzled-2 signaling pathway" EXACT []
synonym: "inhibition of frizzled-2 signaling pathway" NARROW []
synonym: "negative regulation of frizzled-2 signaling pathway" EXACT []
synonym: "negative regulation of frizzled-2 signalling pathway" EXACT []
is_a: GO:0008591 ! regulation of Wnt receptor signaling pathway, calcium modulating pathway
is_a: GO:0030178 ! negative regulation of Wnt receptor signaling pathway
relationship: negatively_regulates GO:0007223 ! Wnt receptor signaling pathway, calcium modulating pathway

[Term]
id: GO:0045813
name: positive regulation of Wnt receptor signaling pathway, calcium modulating pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the frizzled-2 signaling pathway." [GOC:go_curators]
synonym: "activation of frizzled-2 signaling pathway" NARROW []
synonym: "positive regulation of frizzled-2 signaling pathway" EXACT []
synonym: "positive regulation of frizzled-2 signalling pathway" EXACT []
synonym: "stimulation of frizzled-2 signaling pathway" NARROW []
synonym: "up regulation of frizzled-2 signaling pathway" EXACT []
synonym: "up-regulation of frizzled-2 signaling pathway" EXACT []
synonym: "upregulation of frizzled-2 signaling pathway" EXACT []
is_a: GO:0008591 ! regulation of Wnt receptor signaling pathway, calcium modulating pathway
is_a: GO:0030177 ! positive regulation of Wnt receptor signaling pathway
relationship: positively_regulates GO:0007223 ! Wnt receptor signaling pathway, calcium modulating pathway

[Term]
id: GO:0045814
name: negative regulation of gene expression, epigenetic
namespace: biological_process
def: "Any epigenetic process that stops, prevents or reduces the rate of gene expression." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of gene expression, epigenetic" EXACT []
synonym: "down-regulation of gene expression, epigenetic" EXACT []
synonym: "downregulation of gene expression, epigenetic" EXACT []
synonym: "inhibition of gene expression, epigenetic" NARROW []
is_a: GO:0010629 ! negative regulation of gene expression
is_a: GO:0040029 ! regulation of gene expression, epigenetic

[Term]
id: GO:0045815
name: positive regulation of gene expression, epigenetic
namespace: biological_process
def: "Any epigenetic process that activates or increases the rate of gene expression." [GOC:go_curators]
synonym: "activation of gene expression, epigenetic" NARROW []
synonym: "stimulation of gene expression, epigenetic" NARROW []
synonym: "up regulation of gene expression, epigenetic" EXACT []
synonym: "up-regulation of gene expression, epigenetic" EXACT []
synonym: "upregulation of gene expression, epigenetic" EXACT []
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0040029 ! regulation of gene expression, epigenetic

[Term]
id: GO:0045816
name: negative regulation of transcription from RNA polymerase II promoter, global
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of global transcription from an RNA polymerase II promoter." [GOC:go_curators]
synonym: "down regulation of global transcription from RNA polymerase II promoter" EXACT []
synonym: "down-regulation of global transcription from RNA polymerase II promoter" EXACT []
synonym: "downregulation of global transcription from RNA polymerase II promoter" EXACT []
synonym: "inhibition of global transcription from RNA polymerase II promoter" NARROW []
synonym: "negative regulation of global transcription from Pol II promoter" EXACT []
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter
is_a: GO:0006358 ! regulation of transcription from RNA polymerase II promoter, global

[Term]
id: GO:0045817
name: positive regulation of transcription from RNA polymerase II promoter, global
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of global transcription from an RNA polymerase II promoter." [GOC:go_curators]
synonym: "activation of global transcription from RNA polymerase II promoter" NARROW []
synonym: "positive regulation of global transcription from Pol II promoter" EXACT []
synonym: "stimulation of global transcription from RNA polymerase II promoter" NARROW []
synonym: "up regulation of global transcription from RNA polymerase II promoter" EXACT []
synonym: "up-regulation of global transcription from RNA polymerase II promoter" EXACT []
synonym: "upregulation of global transcription from RNA polymerase II promoter" EXACT []
is_a: GO:0006358 ! regulation of transcription from RNA polymerase II promoter, global
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter

[Term]
id: GO:0045818
name: negative regulation of glycogen catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of glycogen catabolic process" EXACT []
synonym: "down-regulation of glycogen catabolic process" EXACT []
synonym: "downregulation of glycogen catabolic process" EXACT []
synonym: "inhibition of glycogen catabolic process" NARROW []
synonym: "negative regulation of glycogen breakdown" EXACT []
synonym: "negative regulation of glycogen catabolism" EXACT []
synonym: "negative regulation of glycogen degradation" EXACT []
is_a: GO:0005981 ! regulation of glycogen catabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0070874 ! negative regulation of glycogen metabolic process
relationship: negatively_regulates GO:0005980 ! glycogen catabolic process

[Term]
id: GO:0045819
name: positive regulation of glycogen catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of glycogen catabolic process" NARROW []
synonym: "positive regulation of glycogen breakdown" EXACT []
synonym: "positive regulation of glycogen catabolism" EXACT []
synonym: "positive regulation of glycogen degradation" EXACT []
synonym: "stimulation of glycogen catabolic process" NARROW []
synonym: "up regulation of glycogen catabolic process" EXACT []
synonym: "up-regulation of glycogen catabolic process" EXACT []
synonym: "upregulation of glycogen catabolic process" EXACT []
is_a: GO:0005981 ! regulation of glycogen catabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0070875 ! positive regulation of glycogen metabolic process
relationship: positively_regulates GO:0005980 ! glycogen catabolic process

[Term]
id: GO:0045820
name: negative regulation of glycolysis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycolysis." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of glycolysis" EXACT []
synonym: "down-regulation of glycolysis" EXACT []
synonym: "downregulation of glycolysis" EXACT []
synonym: "inhibition of glycolysis" NARROW []
is_a: GO:0006110 ! regulation of glycolysis
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
relationship: negatively_regulates GO:0006096 ! glycolysis

[Term]
id: GO:0045821
name: positive regulation of glycolysis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycolysis." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of glycolysis" NARROW []
synonym: "stimulation of glycolysis" NARROW []
synonym: "up regulation of glycolysis" EXACT []
synonym: "up-regulation of glycolysis" EXACT []
synonym: "upregulation of glycolysis" EXACT []
is_a: GO:0006110 ! regulation of glycolysis
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0010907 ! positive regulation of glucose metabolic process
is_a: GO:0031331 ! positive regulation of cellular catabolic process
relationship: positively_regulates GO:0006096 ! glycolysis

[Term]
id: GO:0045822
name: negative regulation of heart contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of heart contraction." [GOC:go_curators]
synonym: "down regulation of heart contraction" EXACT []
synonym: "down-regulation of heart contraction" EXACT []
synonym: "downregulation of heart contraction" EXACT []
synonym: "inhibition of heart contraction" NARROW []
synonym: "negative regulation of cardiac contraction" RELATED []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0060047 ! heart contraction

[Term]
id: GO:0045823
name: positive regulation of heart contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators]
synonym: "activation of heart contraction" NARROW []
synonym: "positive regulation of cardiac contraction" EXACT []
synonym: "stimulation of heart contraction" NARROW []
synonym: "up regulation of heart contraction" EXACT []
synonym: "up-regulation of heart contraction" EXACT []
synonym: "upregulation of heart contraction" EXACT []
is_a: GO:0008016 ! regulation of heart contraction
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0060047 ! heart contraction

[Term]
id: GO:0045824
name: negative regulation of innate immune response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators]
synonym: "down regulation of innate immune response" EXACT []
synonym: "down-regulation of innate immune response" EXACT []
synonym: "downregulation of innate immune response" EXACT []
synonym: "inhibition of innate immune response" NARROW []
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0050777 ! negative regulation of immune response
relationship: negatively_regulates GO:0045087 ! innate immune response

[Term]
id: GO:0045825
name: negative regulation of intermediate filament polymerization and/or depolymerization
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of intermediate filament polymerization and/or depolymerization." [GOC:go_curators]
comment: This term was made obsolete because it has been split.
is_obsolete: true
consider: GO:0030840
consider: GO:0030843

[Term]
id: GO:0045826
name: positive regulation of intermediate filament polymerization and/or depolymerization
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization and/or depolymerization." [GOC:go_curators]
comment: This term was made obsolete because it has been split.
is_obsolete: true
consider: GO:0030841
consider: GO:0030844

[Term]
id: GO:0045827
name: negative regulation of isoprenoid metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of isoprenoid metabolic process" EXACT []
synonym: "down-regulation of isoprenoid metabolic process" EXACT []
synonym: "downregulation of isoprenoid metabolic process" EXACT []
synonym: "inhibition of isoprenoid metabolic process" NARROW []
synonym: "negative regulation of isoprenoid metabolism" EXACT []
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
relationship: negatively_regulates GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0045828
name: positive regulation of isoprenoid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of isoprenoid metabolic process" NARROW []
synonym: "positive regulation of isoprenoid metabolism" EXACT []
synonym: "stimulation of isoprenoid metabolic process" NARROW []
synonym: "up regulation of isoprenoid metabolic process" EXACT []
synonym: "up-regulation of isoprenoid metabolic process" EXACT []
synonym: "upregulation of isoprenoid metabolic process" EXACT []
is_a: GO:0019747 ! regulation of isoprenoid metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
relationship: positively_regulates GO:0006720 ! isoprenoid metabolic process

[Term]
id: GO:0045829
name: negative regulation of isotype switching
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching." [GOC:go_curators]
synonym: "down regulation of isotype switching" EXACT []
synonym: "down-regulation of isotype switching" EXACT []
synonym: "downregulation of isotype switching" EXACT []
synonym: "inhibition of isotype switching" NARROW []
synonym: "negative regulation of class switch recombination" EXACT []
synonym: "negative regulation of class switching" EXACT []
synonym: "negative regulation of isotype switch recombination" EXACT []
is_a: GO:0045191 ! regulation of isotype switching
is_a: GO:0045910 ! negative regulation of DNA recombination
is_a: GO:0050869 ! negative regulation of B cell activation
relationship: negatively_regulates GO:0045190 ! isotype switching

[Term]
id: GO:0045830
name: positive regulation of isotype switching
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isotype switching." [GOC:go_curators]
synonym: "activation of isotype switching" NARROW []
synonym: "positive regulation of class switch recombination" EXACT []
synonym: "positive regulation of class switching" EXACT []
synonym: "positive regulation of isotype switch recombination" EXACT []
synonym: "stimulation of isotype switching" NARROW []
synonym: "up regulation of isotype switching" EXACT []
synonym: "up-regulation of isotype switching" EXACT []
synonym: "upregulation of isotype switching" EXACT []
is_a: GO:0045191 ! regulation of isotype switching
is_a: GO:0045911 ! positive regulation of DNA recombination
is_a: GO:0050871 ! positive regulation of B cell activation
relationship: positively_regulates GO:0045190 ! isotype switching

[Term]
id: GO:0045831
name: negative regulation of light-activated channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of light-activated channel activity." [GOC:go_curators]
synonym: "down regulation of light-activated channel activity" EXACT []
synonym: "down-regulation of light-activated channel activity" EXACT []
synonym: "downregulation of light-activated channel activity" EXACT []
synonym: "inhibition of light-activated channel activity" NARROW []
is_a: GO:0016061 ! regulation of light-activated channel activity
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity

[Term]
id: GO:0045832
name: positive regulation of light-activated channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of light-activated channel activity." [GOC:go_curators]
synonym: "activation of light-activated channel activity" NARROW []
synonym: "stimulation of light-activated channel activity" NARROW []
synonym: "up regulation of light-activated channel activity" EXACT []
synonym: "up-regulation of light-activated channel activity" EXACT []
synonym: "upregulation of light-activated channel activity" EXACT []
is_a: GO:0016061 ! regulation of light-activated channel activity
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity

[Term]
id: GO:0045833
name: negative regulation of lipid metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of lipid metabolic process" EXACT []
synonym: "down-regulation of lipid metabolic process" EXACT []
synonym: "downregulation of lipid metabolic process" EXACT []
synonym: "inhibition of lipid metabolic process" NARROW []
synonym: "negative regulation of lipid metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
relationship: negatively_regulates GO:0006629 ! lipid metabolic process

[Term]
id: GO:0045834
name: positive regulation of lipid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of lipid metabolic process" NARROW []
synonym: "positive regulation of lipid metabolism" EXACT []
synonym: "stimulation of lipid metabolic process" NARROW []
synonym: "up regulation of lipid metabolic process" EXACT []
synonym: "up-regulation of lipid metabolic process" EXACT []
synonym: "upregulation of lipid metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
relationship: positively_regulates GO:0006629 ! lipid metabolic process

[Term]
id: GO:0045835
name: negative regulation of meiosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiosis." [GOC:go_curators]
synonym: "down regulation of meiosis" EXACT []
synonym: "down-regulation of meiosis" EXACT []
synonym: "downregulation of meiosis" EXACT []
synonym: "inhibition of meiosis" NARROW []
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0040020 ! regulation of meiosis
relationship: negatively_regulates GO:0007126 ! meiosis

[Term]
id: GO:0045836
name: positive regulation of meiosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators]
synonym: "activation of meiosis" NARROW []
synonym: "stimulation of meiosis" NARROW []
synonym: "up regulation of meiosis" EXACT []
synonym: "up-regulation of meiosis" EXACT []
synonym: "upregulation of meiosis" EXACT []
is_a: GO:0040020 ! regulation of meiosis
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0007126 ! meiosis

[Term]
id: GO:0045837
name: negative regulation of membrane potential
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:go_curators]
synonym: "down regulation of membrane potential" EXACT []
synonym: "down-regulation of membrane potential" EXACT []
synonym: "downregulation of membrane potential" EXACT []
synonym: "inhibition of membrane potential" NARROW []
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0045838
name: positive regulation of membrane potential
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:go_curators]
synonym: "activation of membrane potential" NARROW []
synonym: "stimulation of membrane potential" NARROW []
synonym: "up regulation of membrane potential" EXACT []
synonym: "up-regulation of membrane potential" EXACT []
synonym: "upregulation of membrane potential" EXACT []
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0045839
name: negative regulation of mitosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of mitosis" EXACT []
synonym: "down-regulation of mitosis" EXACT []
synonym: "downregulation of mitosis" EXACT []
synonym: "inhibition of mitosis" NARROW []
is_a: GO:0007088 ! regulation of mitosis
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0045786 ! negative regulation of cell cycle
is_a: GO:0051784 ! negative regulation of nuclear division
relationship: negatively_regulates GO:0007067 ! mitosis

[Term]
id: GO:0045840
name: positive regulation of mitosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators]
synonym: "activation of mitosis" NARROW []
synonym: "mitogenic activity" NARROW []
synonym: "stimulation of mitosis" NARROW []
synonym: "up regulation of mitosis" EXACT []
synonym: "up-regulation of mitosis" EXACT []
synonym: "upregulation of mitosis" EXACT []
is_a: GO:0007088 ! regulation of mitosis
is_a: GO:0045787 ! positive regulation of cell cycle
is_a: GO:0051785 ! positive regulation of nuclear division
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0007067 ! mitosis

[Term]
id: GO:0045841
name: negative regulation of mitotic metaphase/anaphase transition
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators]
synonym: "down regulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "down-regulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "downregulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "inhibition of mitotic metaphase/anaphase transition" NARROW []
is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition
is_a: GO:0045839 ! negative regulation of mitosis
relationship: negatively_regulates GO:0007091 ! mitotic metaphase/anaphase transition

[Term]
id: GO:0045842
name: positive regulation of mitotic metaphase/anaphase transition
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators]
synonym: "activation of mitotic metaphase/anaphase transition" NARROW []
synonym: "stimulation of mitotic metaphase/anaphase transition" NARROW []
synonym: "up regulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "up-regulation of mitotic metaphase/anaphase transition" EXACT []
synonym: "upregulation of mitotic metaphase/anaphase transition" EXACT []
is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition
is_a: GO:0045840 ! positive regulation of mitosis
relationship: positively_regulates GO:0007091 ! mitotic metaphase/anaphase transition

[Term]
id: GO:0045843
name: negative regulation of striated muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of striated muscle development." [GOC:go_curators]
synonym: "down regulation of striated muscle development" EXACT []
synonym: "down-regulation of striated muscle development" EXACT []
synonym: "downregulation of striated muscle development" EXACT []
synonym: "inhibition of striated muscle development" NARROW []
is_a: GO:0016202 ! regulation of striated muscle tissue development
is_a: GO:0048635 ! negative regulation of muscle organ development
relationship: negatively_regulates GO:0014706 ! striated muscle tissue development

[Term]
id: GO:0045844
name: positive regulation of striated muscle tissue development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of striated muscle development." [GOC:go_curators]
synonym: "activation of striated muscle development" NARROW []
synonym: "stimulation of striated muscle development" NARROW []
synonym: "up regulation of striated muscle development" EXACT []
synonym: "up-regulation of striated muscle development" EXACT []
synonym: "upregulation of striated muscle development" EXACT []
is_a: GO:0016202 ! regulation of striated muscle tissue development
is_a: GO:0048636 ! positive regulation of muscle organ development
relationship: positively_regulates GO:0014706 ! striated muscle tissue development

[Term]
id: GO:0045847
name: negative regulation of nitrogen utilization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nitrogen utilization." [GOC:go_curators]
synonym: "down regulation of nitrogen utilization" EXACT []
synonym: "down-regulation of nitrogen utilization" EXACT []
synonym: "downregulation of nitrogen utilization" EXACT []
synonym: "inhibition of nitrogen utilization" NARROW []
is_a: GO:0006808 ! regulation of nitrogen utilization
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
relationship: negatively_regulates GO:0019740 ! nitrogen utilization

[Term]
id: GO:0045848
name: positive regulation of nitrogen utilization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nitrogen utilization." [GOC:go_curators]
synonym: "activation of nitrogen utilization" NARROW []
synonym: "stimulation of nitrogen utilization" NARROW []
synonym: "up regulation of nitrogen utilization" EXACT []
synonym: "up-regulation of nitrogen utilization" EXACT []
synonym: "upregulation of nitrogen utilization" EXACT []
is_a: GO:0006808 ! regulation of nitrogen utilization
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
relationship: positively_regulates GO:0019740 ! nitrogen utilization

[Term]
id: GO:0045849
name: negative regulation of nurse cell apoptosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nurse cell apoptosis." [GOC:go_curators]
synonym: "down regulation of nurse cell apoptosis" EXACT []
synonym: "down-regulation of nurse cell apoptosis" EXACT []
synonym: "downregulation of nurse cell apoptosis" EXACT []
synonym: "inhibition of nurse cell apoptosis" NARROW []
is_a: GO:0043066 ! negative regulation of apoptosis
is_a: GO:0045477 ! regulation of nurse cell apoptosis
relationship: negatively_regulates GO:0045476 ! nurse cell apoptosis

[Term]
id: GO:0045850
name: positive regulation of nurse cell apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nurse cell apoptosis." [GOC:go_curators]
synonym: "activation of nurse cell apoptosis" NARROW []
synonym: "stimulation of nurse cell apoptosis" NARROW []
synonym: "up regulation of nurse cell apoptosis" EXACT []
synonym: "up-regulation of nurse cell apoptosis" EXACT []
synonym: "upregulation of nurse cell apoptosis" EXACT []
is_a: GO:0043065 ! positive regulation of apoptosis
is_a: GO:0045477 ! regulation of nurse cell apoptosis
relationship: positively_regulates GO:0045476 ! nurse cell apoptosis

[Term]
id: GO:0045851
name: pH reduction
namespace: biological_process
def: "Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:go_curators]
synonym: "acidification" EXACT []
is_a: GO:0006885 ! regulation of pH

[Term]
id: GO:0045852
name: pH elevation
namespace: biological_process
def: "Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:go_curators]
is_a: GO:0006885 ! regulation of pH

[Term]
id: GO:0045853
name: negative regulation of bicoid mRNA localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the process by which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:go_curators]
synonym: "down regulation of bicoid mRNA localization" EXACT []
synonym: "down-regulation of bicoid mRNA localization" EXACT []
synonym: "downregulation of bicoid mRNA localization" EXACT []
synonym: "inhibition of bicoid mRNA localization" NARROW []
is_a: GO:0008359 ! regulation of bicoid mRNA localization
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0045450 ! bicoid mRNA localization

[Term]
id: GO:0045854
name: positive regulation of bicoid mRNA localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process by which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:go_curators]
synonym: "activation of bicoid mRNA localization" NARROW []
synonym: "stimulation of bicoid mRNA localization" NARROW []
synonym: "up regulation of bicoid mRNA localization" EXACT []
synonym: "up-regulation of bicoid mRNA localization" EXACT []
synonym: "upregulation of bicoid mRNA localization" EXACT []
is_a: GO:0008359 ! regulation of bicoid mRNA localization
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0045450 ! bicoid mRNA localization

[Term]
id: GO:0045855
name: negative regulation of pole plasm oskar mRNA localization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a process by which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
synonym: "down regulation of pole plasm oskar mRNA localization" EXACT []
synonym: "down-regulation of pole plasm oskar mRNA localization" EXACT []
synonym: "downregulation of pole plasm oskar mRNA localization" EXACT []
synonym: "inhibition of pole plasm oskar mRNA localization" NARROW []
synonym: "negative regulation of oocyte pole plasm oskar mRNA localization" EXACT []
is_a: GO:0007317 ! regulation of pole plasm oskar mRNA localization
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0045451 ! pole plasm oskar mRNA localization

[Term]
id: GO:0045856
name: positive regulation of pole plasm oskar mRNA localization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process by which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators]
synonym: "activation of pole plasm oskar mRNA localization" NARROW []
synonym: "positive regulation of oocyte pole plasm oskar mRNA localization" EXACT []
synonym: "stimulation of pole plasm oskar mRNA localization" NARROW []
synonym: "up regulation of pole plasm oskar mRNA localization" EXACT []
synonym: "up-regulation of pole plasm oskar mRNA localization" EXACT []
synonym: "upregulation of pole plasm oskar mRNA localization" EXACT []
is_a: GO:0007317 ! regulation of pole plasm oskar mRNA localization
is_a: GO:0048522 ! positive regulation of cellular process
relationship: positively_regulates GO:0045451 ! pole plasm oskar mRNA localization

[Term]
id: GO:0045857
name: negative regulation of molecular function, epigenetic
namespace: biological_process
def: "Any heritable epigenetic process that stops, prevents or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of protein activity, epigenetic" EXACT []
synonym: "down-regulation of protein activity, epigenetic" EXACT []
synonym: "downregulation of protein activity, epigenetic" EXACT []
synonym: "inhibition of protein activity, epigenetic" NARROW []
synonym: "negative regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb]
is_a: GO:0040030 ! regulation of molecular function, epigenetic
is_a: GO:0044092 ! negative regulation of molecular function

[Term]
id: GO:0045858
name: positive regulation of molecular function, epigenetic
namespace: biological_process
def: "Any heritable epigenetic process that increases the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of protein activity, epigenetic" NARROW []
synonym: "positive regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of protein activity, epigenetic" NARROW []
synonym: "up regulation of protein activity, epigenetic" EXACT []
synonym: "up-regulation of protein activity, epigenetic" EXACT []
synonym: "upregulation of protein activity, epigenetic" EXACT []
is_a: GO:0040030 ! regulation of molecular function, epigenetic
is_a: GO:0044093 ! positive regulation of molecular function

[Term]
id: GO:0045859
name: regulation of protein kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0043549 ! regulation of kinase activity

[Term]
id: GO:0045860
name: positive regulation of protein kinase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators]
subset: gosubset_prok
synonym: "stimulation of protein kinase activity" NARROW []
synonym: "up regulation of protein kinase activity" EXACT []
synonym: "up-regulation of protein kinase activity" EXACT []
synonym: "upregulation of protein kinase activity" EXACT []
is_a: GO:0033674 ! positive regulation of kinase activity
is_a: GO:0045859 ! regulation of protein kinase activity

[Term]
id: GO:0045861
name: negative regulation of proteolysis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of proteolysis" EXACT []
synonym: "down-regulation of proteolysis" EXACT []
synonym: "downregulation of proteolysis" EXACT []
synonym: "inhibition of proteolysis" NARROW []
synonym: "negative regulation of peptidolysis" EXACT []
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:0032269 ! negative regulation of cellular protein metabolic process
relationship: negatively_regulates GO:0006508 ! proteolysis

[Term]
id: GO:0045862
name: positive regulation of proteolysis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of proteolysis" NARROW []
synonym: "positive regulation of peptidolysis" EXACT []
synonym: "stimulation of proteolysis" NARROW []
synonym: "up regulation of proteolysis" EXACT []
synonym: "up-regulation of proteolysis" EXACT []
synonym: "upregulation of proteolysis" EXACT []
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:0032270 ! positive regulation of cellular protein metabolic process
relationship: positively_regulates GO:0006508 ! proteolysis

[Term]
id: GO:0045863
name: negative regulation of pteridine metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of pteridine metabolic process" EXACT []
synonym: "down-regulation of pteridine metabolic process" EXACT []
synonym: "downregulation of pteridine metabolic process" EXACT []
synonym: "inhibition of pteridine metabolic process" NARROW []
synonym: "negative regulation of pteridine metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0042068 ! regulation of pteridine metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
relationship: negatively_regulates GO:0019889 ! pteridine metabolic process

[Term]
id: GO:0045864
name: positive regulation of pteridine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of pteridine metabolic process" NARROW []
synonym: "positive regulation of pteridine metabolism" EXACT []
synonym: "stimulation of pteridine metabolic process" NARROW []
synonym: "up regulation of pteridine metabolic process" EXACT []
synonym: "up-regulation of pteridine metabolic process" EXACT []
synonym: "upregulation of pteridine metabolic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0042068 ! regulation of pteridine metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
relationship: positively_regulates GO:0019889 ! pteridine metabolic process

[Term]
id: GO:0045865
name: regulation of recombination within rDNA repeats
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it describes a substrate-specific process.
is_obsolete: true
replaced_by: GO:0000019

[Term]
id: GO:0045866
name: positive regulation of recombination within rDNA repeats
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: This term was made obsolete because it describes a substrate-specific process.
is_obsolete: true
consider: GO:0045951

[Term]
id: GO:0045869
name: negative regulation of retroviral genome replication
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retroviral genome replication." [GOC:go_curators]
synonym: "down regulation of retroviral genome replication" EXACT []
synonym: "down-regulation of retroviral genome replication" EXACT []
synonym: "downregulation of retroviral genome replication" EXACT []
synonym: "inhibition of retroviral genome replication" NARROW []
is_a: GO:0045071 ! negative regulation of viral genome replication
is_a: GO:0045091 ! regulation of retroviral genome replication
relationship: negatively_regulates GO:0045090 ! retroviral genome replication

[Term]
id: GO:0045870
name: positive regulation of retroviral genome replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retroviral genome replication." [GOC:go_curators]
synonym: "activation of retroviral genome replication" NARROW []
synonym: "stimulation of retroviral genome replication" NARROW []
synonym: "up regulation of retroviral genome replication" EXACT []
synonym: "up-regulation of retroviral genome replication" EXACT []
synonym: "upregulation of retroviral genome replication" EXACT []
is_a: GO:0045070 ! positive regulation of viral genome replication
is_a: GO:0045091 ! regulation of retroviral genome replication
relationship: positively_regulates GO:0045090 ! retroviral genome replication

[Term]
id: GO:0045871
name: negative regulation of rhodopsin gene expression
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of rhodopsin gene expression." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of rhodopsin gene activity" EXACT []
synonym: "down-regulation of rhodopsin gene activity" EXACT []
synonym: "downregulation of rhodopsin gene activity" EXACT []
synonym: "inhibition of rhodopsin gene activity" NARROW []
synonym: "negative regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007468 ! regulation of rhodopsin gene expression
is_a: GO:0010629 ! negative regulation of gene expression

[Term]
id: GO:0045872
name: positive regulation of rhodopsin gene expression
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of rhodopsin gene expression." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of rhodopsin gene activity" NARROW []
synonym: "positive regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of rhodopsin gene activity" NARROW []
synonym: "up regulation of rhodopsin gene activity" EXACT []
synonym: "up-regulation of rhodopsin gene activity" EXACT []
synonym: "upregulation of rhodopsin gene activity" EXACT []
is_a: GO:0007468 ! regulation of rhodopsin gene expression
is_a: GO:0010628 ! positive regulation of gene expression

[Term]
id: GO:0045873
name: negative regulation of sevenless signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators]
synonym: "down regulation of sevenless signaling pathway" EXACT []
synonym: "down-regulation of sevenless signaling pathway" EXACT []
synonym: "downregulation of sevenless signaling pathway" EXACT []
synonym: "inhibition of sevenless signaling pathway" NARROW []
synonym: "negative regulation of sev signaling pathway" EXACT []
synonym: "negative regulation of sevenless signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0045501 ! regulation of sevenless signaling pathway
relationship: negatively_regulates GO:0045500 ! sevenless signaling pathway

[Term]
id: GO:0045874
name: positive regulation of sevenless signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators]
synonym: "activation of sevenless signaling pathway" NARROW []
synonym: "positive regulation of sev signaling pathway" EXACT []
synonym: "positive regulation of sevenless signalling pathway" EXACT []
synonym: "stimulation of sevenless signaling pathway" NARROW []
synonym: "up regulation of sevenless signaling pathway" EXACT []
synonym: "up-regulation of sevenless signaling pathway" EXACT []
synonym: "upregulation of sevenless signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0045501 ! regulation of sevenless signaling pathway
relationship: positively_regulates GO:0045500 ! sevenless signaling pathway

[Term]
id: GO:0045875
name: negative regulation of sister chromatid cohesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators]
synonym: "down regulation of sister chromatid cohesion" EXACT []
synonym: "down-regulation of sister chromatid cohesion" EXACT []
synonym: "downregulation of sister chromatid cohesion" EXACT []
synonym: "inhibition of sister chromatid cohesion" NARROW []
is_a: GO:0007063 ! regulation of sister chromatid cohesion
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0010948 ! negative regulation of cell cycle process
relationship: negatively_regulates GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0045876
name: positive regulation of sister chromatid cohesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators]
synonym: "activation of sister chromatid cohesion" NARROW []
synonym: "stimulation of sister chromatid cohesion" NARROW []
synonym: "up regulation of sister chromatid cohesion" EXACT []
synonym: "up-regulation of sister chromatid cohesion" EXACT []
synonym: "upregulation of sister chromatid cohesion" EXACT []
is_a: GO:0007063 ! regulation of sister chromatid cohesion
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0045879
name: negative regulation of smoothened signaling pathway
namespace: biological_process
alt_id: GO:0045877
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
synonym: "down regulation of smoothened signaling pathway" EXACT []
synonym: "down-regulation of smoothened signaling pathway" EXACT []
synonym: "downregulation of smoothened signaling pathway" EXACT []
synonym: "inhibition of smoothened signaling pathway" NARROW []
synonym: "negative regulation of smoothened activity" RELATED []
synonym: "negative regulation of smoothened by patched" NARROW []
synonym: "negative regulation of smoothened receptor activity by patched" RELATED []
synonym: "negative regulation of smoothened signalling pathway" EXACT []
is_a: GO:0008589 ! regulation of smoothened signaling pathway
is_a: GO:0009968 ! negative regulation of signal transduction
relationship: negatively_regulates GO:0007224 ! smoothened signaling pathway

[Term]
id: GO:0045880
name: positive regulation of smoothened signaling pathway
namespace: biological_process
alt_id: GO:0045878
def: "Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators]
synonym: "activation of smoothened signaling pathway" NARROW []
synonym: "positive regulation of smoothened by patched" RELATED []
synonym: "positive regulation of smoothened receptor activity by patched" RELATED []
synonym: "positive regulation of smoothened signalling pathway" EXACT []
synonym: "stimulation of smoothened signaling pathway" NARROW []
synonym: "up regulation of smoothened signaling pathway" EXACT []
synonym: "up-regulation of smoothened signaling pathway" EXACT []
synonym: "upregulation of smoothened signaling pathway" EXACT []
is_a: GO:0008589 ! regulation of smoothened signaling pathway
is_a: GO:0009967 ! positive regulation of signal transduction
relationship: positively_regulates GO:0007224 ! smoothened signaling pathway

[Term]
id: GO:0045881
name: positive regulation of sporulation resulting in formation of a cellular spore
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sporulation." [GOC:go_curators]
synonym: "activation of sporulation" NARROW []
synonym: "stimulation of sporulation" NARROW []
synonym: "up regulation of sporulation" EXACT []
synonym: "up-regulation of sporulation" EXACT []
synonym: "upregulation of sporulation" EXACT []
is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore
is_a: GO:0043938 ! positive regulation of sporulation
is_a: GO:0045597 ! positive regulation of cell differentiation
relationship: positively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore

[Term]
id: GO:0045882
name: negative regulation of sulfur utilization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sulfur utilization." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of sulfur utilization" EXACT []
synonym: "down-regulation of sulfur utilization" EXACT []
synonym: "downregulation of sulfur utilization" EXACT []
synonym: "inhibition of sulfur utilization" NARROW []
synonym: "negative regulation of sulphur utilization" EXACT []
is_a: GO:0006792 ! regulation of sulfur utilization
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
relationship: negatively_regulates GO:0006791 ! sulfur utilization

[Term]
id: GO:0045883
name: positive regulation of sulfur utilization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of sulfur utilization." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of sulfur utilization" NARROW []
synonym: "positive regulation of sulphur utilization" EXACT []
synonym: "stimulation of sulfur utilization" NARROW []
synonym: "up regulation of sulfur utilization" EXACT []
synonym: "up-regulation of sulfur utilization" EXACT []
synonym: "upregulation of sulfur utilization" EXACT []
is_a: GO:0006792 ! regulation of sulfur utilization
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
relationship: positively_regulates GO:0006791 ! sulfur utilization

[Term]
id: GO:0045884
name: regulation of survival gene product expression
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb]
synonym: "regulation of survival gene products" BROAD []
is_a: GO:0006916 ! anti-apoptosis
is_a: GO:0010468 ! regulation of gene expression

[Term]
id: GO:0045885
name: positive regulation of survival gene product expression
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of survival gene product activity" BROAD []
synonym: "positive regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb]
synonym: "positive regulation of survival gene products" BROAD []
synonym: "stimulation of survival gene product activity" NARROW []
synonym: "up regulation of survival gene product activity" BROAD []
synonym: "up-regulation of survival gene product activity" BROAD []
synonym: "upregulation of survival gene product activity" BROAD []
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0045884 ! regulation of survival gene product expression

[Term]
id: GO:0045886
name: negative regulation of synaptic growth at neuromuscular junction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
synonym: "down regulation of synaptic growth at neuromuscular junction" EXACT []
synonym: "down-regulation of synaptic growth at neuromuscular junction" EXACT []
synonym: "downregulation of synaptic growth at neuromuscular junction" EXACT []
synonym: "inhibition of synaptic growth at neuromuscular junction" NARROW []
is_a: GO:0008582 ! regulation of synaptic growth at neuromuscular junction
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0051964 ! negative regulation of synaptogenesis
relationship: negatively_regulates GO:0051124 ! synaptic growth at neuromuscular junction

[Term]
id: GO:0045887
name: positive regulation of synaptic growth at neuromuscular junction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic growth at neuromuscular junction." [GOC:go_curators]
synonym: "activation of synaptic growth at neuromuscular junction" NARROW []
synonym: "stimulation of synaptic growth at neuromuscular junction" NARROW []
synonym: "up regulation of synaptic growth at neuromuscular junction" EXACT []
synonym: "up-regulation of synaptic growth at neuromuscular junction" EXACT []
synonym: "upregulation of synaptic growth at neuromuscular junction" EXACT []
is_a: GO:0008582 ! regulation of synaptic growth at neuromuscular junction
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0051965 ! positive regulation of synaptogenesis
relationship: positively_regulates GO:0051124 ! synaptic growth at neuromuscular junction

[Term]
id: GO:0045888
name: regulation of transcription of homeotic gene (Polycomb group)
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
is_obsolete: true
consider: GO:0006342
consider: GO:0048096

[Term]
id: GO:0045889
name: positive regulation of transcription of homeotic gene (Polycomb group)
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
is_obsolete: true
consider: GO:0006342
consider: GO:0048096

[Term]
id: GO:0045890
name: regulation of transcription of homeotic gene (trithorax group)
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
is_obsolete: true
consider: GO:0006342
consider: GO:0048096

[Term]
id: GO:0045891
name: negative regulation of transcription of homeotic gene (trithorax group)
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators]
comment: This term was made obsolete because it relates to a specific gene family rather than a process.
is_obsolete: true
consider: GO:0006342
consider: GO:0048096

[Term]
id: GO:0045892
name: negative regulation of transcription, DNA-dependent
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of transcription, DNA-dependent" EXACT []
synonym: "down-regulation of transcription, DNA-dependent" EXACT []
synonym: "downregulation of transcription, DNA-dependent" EXACT []
synonym: "inhibition of transcription, DNA-dependent" NARROW []
synonym: "negative regulation of cellular transcription, DNA-dependent" EXACT []
is_a: GO:0006355 ! regulation of transcription, DNA-dependent
is_a: GO:0016481 ! negative regulation of transcription
is_a: GO:0051253 ! negative regulation of RNA metabolic process
relationship: negatively_regulates GO:0006351 ! transcription, DNA-dependent

[Term]
id: GO:0045893
name: positive regulation of transcription, DNA-dependent
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of transcription, DNA-dependent" NARROW []
synonym: "positive regulation of cellular transcription, DNA-dependent" EXACT []
synonym: "stimulation of transcription, DNA-dependent" NARROW []
synonym: "up regulation of transcription, DNA-dependent" EXACT []
synonym: "up-regulation of transcription, DNA-dependent" EXACT []
synonym: "upregulation of transcription, DNA-dependent" EXACT []
is_a: GO:0006355 ! regulation of transcription, DNA-dependent
is_a: GO:0045941 ! positive regulation of transcription
is_a: GO:0051254 ! positive regulation of RNA metabolic process
relationship: positively_regulates GO:0006351 ! transcription, DNA-dependent

[Term]
id: GO:0045894
name: negative regulation of transcription, mating-type specific
namespace: biological_process
def: "Any mating-type specific process that stops, prevents or reduces the rate of transcription." [GOC:go_curators]
synonym: "down regulation of transcription, mating-type specific" EXACT []
synonym: "down-regulation of transcription, mating-type specific" EXACT []
synonym: "downregulation of transcription, mating-type specific" EXACT []
synonym: "inhibition of transcription, mating-type specific" NARROW []
is_a: GO:0007532 ! regulation of transcription, mating-type specific
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent

[Term]
id: GO:0045895
name: positive regulation of transcription, mating-type specific
namespace: biological_process
def: "Any mating-type specific process that activates or increases the rate of transcription." [GOC:go_curators]
synonym: "activation of transcription, mating-type specific" NARROW []
synonym: "stimulation of transcription, mating-type specific" NARROW []
synonym: "up regulation of transcription, mating-type specific" EXACT []
synonym: "up-regulation of transcription, mating-type specific" EXACT []
synonym: "upregulation of transcription, mating-type specific" EXACT []
is_a: GO:0007532 ! regulation of transcription, mating-type specific
is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent

[Term]
id: GO:0045896
name: regulation of transcription, mitotic
namespace: biological_process
def: "A cell cycle process that modulates the frequency, rate or extent of transcription during mitosis." [GOC:go_curators]
synonym: "mitotic regulation of transcription" EXACT []
synonym: "regulation of transcription during mitosis" EXACT []
is_a: GO:0006355 ! regulation of transcription, DNA-dependent
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007067 ! mitosis

[Term]
id: GO:0045897
name: positive regulation of transcription, mitotic
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription during mitosis." [GOC:go_curators]
synonym: "activation of transcription, mitotic" NARROW []
synonym: "mitotic activation of transcription" EXACT []
synonym: "positive regulation of transcription during mitosis" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of transcription, mitotic" NARROW []
synonym: "up regulation of transcription, mitotic" EXACT []
synonym: "up-regulation of transcription, mitotic" EXACT []
synonym: "upregulation of transcription, mitotic" EXACT []
is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent
is_a: GO:0045896 ! regulation of transcription, mitotic

[Term]
id: GO:0045898
name: regulation of RNA polymerase II transcriptional preinitiation complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators]
synonym: "regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT []
synonym: "regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT []
synonym: "regulation of RNA polymerase II transcriptional preinitiation complex formation" RELATED []
is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter
relationship: regulates GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly

[Term]
id: GO:0045899
name: positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators]
synonym: "activation of RNA polymerase II transcriptional preinitiation complex assembly" NARROW []
synonym: "positive regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT []
synonym: "positive regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT []
synonym: "positive regulation of RNA polymerase II transcriptional preinitiation complex formation" EXACT []
synonym: "stimulation of RNA polymerase II transcriptional preinitiation complex assembly" NARROW []
synonym: "up regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "up-regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
synonym: "upregulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT []
is_a: GO:0045898 ! regulation of RNA polymerase II transcriptional preinitiation complex assembly
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0051123 ! RNA polymerase II transcriptional preinitiation complex assembly

[Term]
id: GO:0045900
name: negative regulation of translational elongation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of translational elongation." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of translational elongation" EXACT []
synonym: "down-regulation of translational elongation" EXACT []
synonym: "downregulation of translational elongation" EXACT []
synonym: "inhibition of translational elongation" NARROW []
is_a: GO:0006448 ! regulation of translational elongation
is_a: GO:0017148 ! negative regulation of translation
relationship: negatively_regulates GO:0006414 ! translational elongation

[Term]
id: GO:0045901
name: positive regulation of translational elongation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of translational elongation" NARROW []
synonym: "stimulation of translational elongation" NARROW []
synonym: "up regulation of translational elongation" EXACT []
synonym: "up-regulation of translational elongation" EXACT []
synonym: "upregulation of translational elongation" EXACT []
is_a: GO:0006448 ! regulation of translational elongation
is_a: GO:0045727 ! positive regulation of translation
relationship: positively_regulates GO:0006414 ! translational elongation

[Term]
id: GO:0045902
name: negative regulation of translational fidelity
namespace: biological_process
def: "Any process that decreases the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of translational fidelity" EXACT []
synonym: "down-regulation of translational fidelity" EXACT []
synonym: "downregulation of translational fidelity" EXACT []
synonym: "inhibition of translational fidelity" NARROW []
is_a: GO:0006450 ! regulation of translational fidelity
is_a: GO:0017148 ! negative regulation of translation

[Term]
id: GO:0045903
name: positive regulation of translational fidelity
namespace: biological_process
def: "Any process that increases the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "activation of translational fidelity" NARROW []
synonym: "stimulation of translational fidelity" NARROW []
synonym: "up regulation of translational fidelity" EXACT []
synonym: "up-regulation of translational fidelity" EXACT []
synonym: "upregulation of translational fidelity" EXACT []
is_a: GO:0006450 ! regulation of translational fidelity
is_a: GO:0045727 ! positive regulation of translation

[Term]
id: GO:0045904
name: negative regulation of translational termination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of translational termination." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of translational termination" EXACT []
synonym: "down-regulation of translational termination" EXACT []
synonym: "downregulation of translational termination" EXACT []
synonym: "inhibition of translational termination" NARROW []
is_a: GO:0006449 ! regulation of translational termination
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0043242 ! negative regulation of protein complex disassembly
relationship: negatively_regulates GO:0006415 ! translational termination

[Term]
id: GO:0045905
name: positive regulation of translational termination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of translational termination" NARROW []
synonym: "stimulation of translational termination" NARROW []
synonym: "up regulation of translational termination" EXACT []
synonym: "up-regulation of translational termination" EXACT []
synonym: "upregulation of translational termination" EXACT []
is_a: GO:0006449 ! regulation of translational termination
is_a: GO:0043243 ! positive regulation of protein complex disassembly
is_a: GO:0045727 ! positive regulation of translation
relationship: positively_regulates GO:0006415 ! translational termination

[Term]
id: GO:0045906
name: negative regulation of vasoconstriction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasoconstriction." [GOC:go_curators]
synonym: "down regulation of vasoconstriction" EXACT []
synonym: "down-regulation of vasoconstriction" EXACT []
synonym: "downregulation of vasoconstriction" EXACT []
synonym: "inhibition of vasoconstriction" NARROW []
is_a: GO:0019229 ! regulation of vasoconstriction
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0042310 ! vasoconstriction

[Term]
id: GO:0045907
name: positive regulation of vasoconstriction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vasoconstriction." [GOC:go_curators]
synonym: "activation of vasoconstriction" NARROW []
synonym: "stimulation of vasoconstriction" NARROW []
synonym: "up regulation of vasoconstriction" EXACT []
synonym: "up-regulation of vasoconstriction" EXACT []
synonym: "upregulation of vasoconstriction" EXACT []
is_a: GO:0019229 ! regulation of vasoconstriction
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0042310 ! vasoconstriction

[Term]
id: GO:0045908
name: negative regulation of vasodilation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasodilation." [GOC:go_curators]
synonym: "down regulation of vasodilation" EXACT []
synonym: "down-regulation of vasodilation" EXACT []
synonym: "downregulation of vasodilation" EXACT []
synonym: "inhibition of vasodilation" NARROW []
is_a: GO:0042312 ! regulation of vasodilation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0042311 ! vasodilation

[Term]
id: GO:0045909
name: positive regulation of vasodilation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vasodilation." [GOC:go_curators]
synonym: "activation of vasodilation" NARROW []
synonym: "stimulation of vasodilation" NARROW []
synonym: "up regulation of vasodilation" EXACT []
synonym: "up-regulation of vasodilation" EXACT []
synonym: "upregulation of vasodilation" EXACT []
is_a: GO:0042312 ! regulation of vasodilation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0042311 ! vasodilation

[Term]
id: GO:0045910
name: negative regulation of DNA recombination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of DNA recombination" EXACT []
synonym: "down-regulation of DNA recombination" EXACT []
synonym: "downregulation of DNA recombination" EXACT []
synonym: "inhibition of DNA recombination" NARROW []
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0051053 ! negative regulation of DNA metabolic process
relationship: negatively_regulates GO:0006310 ! DNA recombination

[Term]
id: GO:0045911
name: positive regulation of DNA recombination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA recombination." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of DNA recombination" NARROW []
synonym: "stimulation of DNA recombination" NARROW []
synonym: "up regulation of DNA recombination" EXACT []
synonym: "up-regulation of DNA recombination" EXACT []
synonym: "upregulation of DNA recombination" EXACT []
is_a: GO:0000018 ! regulation of DNA recombination
is_a: GO:0051054 ! positive regulation of DNA metabolic process
relationship: positively_regulates GO:0006310 ! DNA recombination

[Term]
id: GO:0045912
name: negative regulation of carbohydrate metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of carbohydrate metabolic process" EXACT []
synonym: "down-regulation of carbohydrate metabolic process" EXACT []
synonym: "downregulation of carbohydrate metabolic process" EXACT []
synonym: "inhibition of carbohydrate metabolic process" NARROW []
synonym: "negative regulation of carbohydrate metabolism" EXACT []
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009892 ! negative regulation of metabolic process
relationship: negatively_regulates GO:0005975 ! carbohydrate metabolic process

[Term]
id: GO:0045913
name: positive regulation of carbohydrate metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of carbohydrate metabolic process" NARROW []
synonym: "positive regulation of carbohydrate metabolism" EXACT []
synonym: "stimulation of carbohydrate metabolic process" NARROW []
synonym: "up regulation of carbohydrate metabolic process" EXACT []
synonym: "up-regulation of carbohydrate metabolic process" EXACT []
synonym: "upregulation of carbohydrate metabolic process" EXACT []
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
is_a: GO:0009893 ! positive regulation of metabolic process
relationship: positively_regulates GO:0005975 ! carbohydrate metabolic process

[Term]
id: GO:0045914
name: negative regulation of catecholamine metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of catecholamine metabolic process" EXACT []
synonym: "down-regulation of catecholamine metabolic process" EXACT []
synonym: "downregulation of catecholamine metabolic process" EXACT []
synonym: "inhibition of catecholamine metabolic process" NARROW []
synonym: "negative regulation of catecholamine metabolism" EXACT []
is_a: GO:0033239 ! negative regulation of cellular amine metabolic process
is_a: GO:0042069 ! regulation of catecholamine metabolic process
relationship: negatively_regulates GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0045915
name: positive regulation of catecholamine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of catecholamine metabolic process" NARROW []
synonym: "positive regulation of catecholamine metabolism" EXACT []
synonym: "stimulation of catecholamine metabolic process" NARROW []
synonym: "up regulation of catecholamine metabolic process" EXACT []
synonym: "up-regulation of catecholamine metabolic process" EXACT []
synonym: "upregulation of catecholamine metabolic process" EXACT []
is_a: GO:0033240 ! positive regulation of cellular amine metabolic process
is_a: GO:0042069 ! regulation of catecholamine metabolic process
relationship: positively_regulates GO:0006584 ! catecholamine metabolic process

[Term]
id: GO:0045916
name: negative regulation of complement activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of complement activation." [GOC:go_curators]
synonym: "down regulation of complement activation" EXACT []
synonym: "down-regulation of complement activation" EXACT []
synonym: "downregulation of complement activation" EXACT []
synonym: "inhibition of complement activation" NARROW []
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002921 ! negative regulation of humoral immune response
is_a: GO:0010955 ! negative regulation of protein maturation by peptide bond cleavage
is_a: GO:0030449 ! regulation of complement activation
relationship: negatively_regulates GO:0006956 ! complement activation

[Term]
id: GO:0045917
name: positive regulation of complement activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement activation." [GOC:go_curators]
synonym: "activation of complement activation" NARROW []
synonym: "stimulation of complement activation" NARROW []
synonym: "up regulation of complement activation" EXACT []
synonym: "up-regulation of complement activation" EXACT []
synonym: "upregulation of complement activation" EXACT []
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0002922 ! positive regulation of humoral immune response
is_a: GO:0010954 ! positive regulation of protein maturation by peptide bond cleavage
is_a: GO:0030449 ! regulation of complement activation
relationship: positively_regulates GO:0006956 ! complement activation

[Term]
id: GO:0045918
name: negative regulation of cytolysis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytolysis." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of cytolysis" EXACT []
synonym: "down-regulation of cytolysis" EXACT []
synonym: "downregulation of cytolysis" EXACT []
synonym: "inhibition of cytolysis" NARROW []
is_a: GO:0042268 ! regulation of cytolysis
is_a: GO:0060548 ! negative regulation of cell death
relationship: negatively_regulates GO:0019835 ! cytolysis

[Term]
id: GO:0045919
name: positive regulation of cytolysis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cytolysis." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of cytolysis" NARROW []
synonym: "stimulation of cytolysis" NARROW []
synonym: "up regulation of cytolysis" EXACT []
synonym: "up-regulation of cytolysis" EXACT []
synonym: "upregulation of cytolysis" EXACT []
is_a: GO:0010942 ! positive regulation of cell death
is_a: GO:0042268 ! regulation of cytolysis
relationship: positively_regulates GO:0019835 ! cytolysis

[Term]
id: GO:0045920
name: negative regulation of exocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of exocytosis." [GOC:go_curators]
synonym: "down regulation of exocytosis" EXACT []
synonym: "down-regulation of exocytosis" EXACT []
synonym: "downregulation of exocytosis" EXACT []
synonym: "inhibition of exocytosis" NARROW []
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051048 ! negative regulation of secretion
relationship: negatively_regulates GO:0006887 ! exocytosis

[Term]
id: GO:0045921
name: positive regulation of exocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of exocytosis" NARROW []
synonym: "stimulation of exocytosis" NARROW []
synonym: "up regulation of exocytosis" EXACT []
synonym: "up-regulation of exocytosis" EXACT []
synonym: "upregulation of exocytosis" EXACT []
is_a: GO:0017157 ! regulation of exocytosis
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051047 ! positive regulation of secretion
relationship: positively_regulates GO:0006887 ! exocytosis

[Term]
id: GO:0045922
name: negative regulation of fatty acid metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of fatty acid metabolic process" EXACT []
synonym: "down-regulation of fatty acid metabolic process" EXACT []
synonym: "downregulation of fatty acid metabolic process" EXACT []
synonym: "inhibition of fatty acid metabolic process" NARROW []
synonym: "negative regulation of fatty acid metabolism" EXACT []
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
relationship: negatively_regulates GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0045923
name: positive regulation of fatty acid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of fatty acid metabolic process" NARROW []
synonym: "positive regulation of fatty acid metabolism" EXACT []
synonym: "stimulation of fatty acid metabolic process" NARROW []
synonym: "up regulation of fatty acid metabolic process" EXACT []
synonym: "up-regulation of fatty acid metabolic process" EXACT []
synonym: "upregulation of fatty acid metabolic process" EXACT []
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
relationship: positively_regulates GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0045924
name: regulation of female receptivity
namespace: biological_process
alt_id: GO:0060181
def: "Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "female receptivity" RELATED [GOC:dph, GOC:tb]
is_a: GO:0060180 ! female mating behavior
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0045925
name: positive regulation of female receptivity
namespace: biological_process
def: "Any process that activates or increases the receptiveness of a female to male advances." [GOC:go_curators]
synonym: "activation of female receptivity" NARROW []
synonym: "stimulation of female receptivity" NARROW []
synonym: "up regulation of female receptivity" EXACT []
synonym: "up-regulation of female receptivity" EXACT []
synonym: "upregulation of female receptivity" EXACT []
is_a: GO:0045924 ! regulation of female receptivity

[Term]
id: GO:0045926
name: negative regulation of growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of growth" EXACT []
synonym: "down-regulation of growth" EXACT []
synonym: "downregulation of growth" EXACT []
synonym: "inhibition of growth" NARROW []
is_a: GO:0040008 ! regulation of growth
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0040007 ! growth

[Term]
id: GO:0045927
name: positive regulation of growth
namespace: biological_process
def: "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of growth" NARROW []
synonym: "stimulation of growth" NARROW []
synonym: "up regulation of growth" EXACT []
synonym: "up-regulation of growth" EXACT []
synonym: "upregulation of growth" EXACT []
is_a: GO:0040008 ! regulation of growth
is_a: GO:0048518 ! positive regulation of biological process
relationship: positively_regulates GO:0040007 ! growth

[Term]
id: GO:0045928
name: negative regulation of juvenile hormone metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators]
synonym: "down regulation of juvenile hormone metabolic process" EXACT []
synonym: "down-regulation of juvenile hormone metabolic process" EXACT []
synonym: "downregulation of juvenile hormone metabolic process" EXACT []
synonym: "inhibition of juvenile hormone metabolic process" NARROW []
synonym: "negative regulation of juvenile hormone metabolism" EXACT []
is_a: GO:0007556 ! regulation of juvenile hormone metabolic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process
relationship: negatively_regulates GO:0006716 ! juvenile hormone metabolic process

[Term]
id: GO:0045929
name: positive regulation of juvenile hormone metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators]
synonym: "activation of juvenile hormone metabolic process" NARROW []
synonym: "positive regulation of juvenile hormone metabolism" EXACT []
synonym: "stimulation of juvenile hormone metabolic process" NARROW []
synonym: "up regulation of juvenile hormone metabolic process" EXACT []
synonym: "up-regulation of juvenile hormone metabolic process" EXACT []
synonym: "upregulation of juvenile hormone metabolic process" EXACT []
is_a: GO:0007556 ! regulation of juvenile hormone metabolic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process
relationship: positively_regulates GO:0006716 ! juvenile hormone metabolic process

[Term]
id: GO:0045930
name: negative regulation of mitotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through mitotic cell cycle" EXACT []
synonym: "downregulation of progression through mitotic cell cycle" EXACT []
synonym: "inhibition of progression through mitotic cell cycle" NARROW []
synonym: "negative regulation of mitotic cell cycle progression" EXACT []
synonym: "negative regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0045786 ! negative regulation of cell cycle
relationship: negatively_regulates GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0045931
name: positive regulation of mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of progression through mitotic cell cycle" NARROW []
synonym: "positive regulation of mitotic cell cycle progression" EXACT []
synonym: "positive regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through mitotic cell cycle" NARROW []
synonym: "up regulation of progression through mitotic cell cycle" EXACT []
synonym: "up-regulation of progression through mitotic cell cycle" EXACT []
synonym: "upregulation of progression through mitotic cell cycle" EXACT []
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0045787 ! positive regulation of cell cycle
relationship: positively_regulates GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0045932
name: negative regulation of muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle contraction." [GOC:go_curators]
synonym: "down regulation of muscle contraction" EXACT []
synonym: "down-regulation of muscle contraction" EXACT []
synonym: "downregulation of muscle contraction" EXACT []
synonym: "inhibition of muscle contraction" NARROW []
is_a: GO:0006937 ! regulation of muscle contraction
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0006936 ! muscle contraction

[Term]
id: GO:0045933
name: positive regulation of muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle contraction." [GOC:go_curators]
synonym: "activation of muscle contraction" NARROW []
synonym: "stimulation of muscle contraction" NARROW []
synonym: "up regulation of muscle contraction" EXACT []
synonym: "up-regulation of muscle contraction" EXACT []
synonym: "upregulation of muscle contraction" EXACT []
is_a: GO:0006937 ! regulation of muscle contraction
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0006936 ! muscle contraction

[Term]
id: GO:0045934
name: negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
namespace: biological_process
def: "Any cellular process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW []
synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
relationship: negatively_regulates GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

[Term]
id: GO:0045935
name: positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
namespace: biological_process
def: "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW []
synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT []
synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW []
synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT []
is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
relationship: positively_regulates GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

[Term]
id: GO:0045936
name: negative regulation of phosphate metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of phosphate metabolic process" EXACT []
synonym: "down-regulation of phosphate metabolic process" EXACT []
synonym: "downregulation of phosphate metabolic process" EXACT []
synonym: "inhibition of phosphate metabolic process" NARROW []
synonym: "negative regulation of phosphate metabolism" EXACT []
is_a: GO:0010563 ! negative regulation of phosphorus metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
relationship: negatively_regulates GO:0006796 ! phosphate metabolic process

[Term]
id: GO:0045937
name: positive regulation of phosphate metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of phosphate metabolic process" NARROW []
synonym: "positive regulation of phosphate metabolism" EXACT []
synonym: "stimulation of phosphate metabolic process" NARROW []
synonym: "up regulation of phosphate metabolic process" EXACT []
synonym: "up-regulation of phosphate metabolic process" EXACT []
synonym: "upregulation of phosphate metabolic process" EXACT []
is_a: GO:0010562 ! positive regulation of phosphorus metabolic process
is_a: GO:0019220 ! regulation of phosphate metabolic process
relationship: positively_regulates GO:0006796 ! phosphate metabolic process

[Term]
id: GO:0045938
name: positive regulation of circadian sleep/wake cycle, sleep
namespace: biological_process
def: "Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators]
synonym: "activation of circadian sleep/wake cycle, sleep" NARROW []
synonym: "positive regulation of sleep" EXACT []
synonym: "stimulation of circadian sleep/wake cycle, sleep" NARROW []
synonym: "up regulation of circadian sleep/wake cycle, sleep" EXACT []
synonym: "up-regulation of circadian sleep/wake cycle, sleep" EXACT []
synonym: "upregulation of circadian sleep/wake cycle, sleep" EXACT []
is_a: GO:0042753 ! positive regulation of circadian rhythm
is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep

[Term]
id: GO:0045939
name: negative regulation of steroid metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of steroid metabolic process" EXACT []
synonym: "down-regulation of steroid metabolic process" EXACT []
synonym: "downregulation of steroid metabolic process" EXACT []
synonym: "inhibition of steroid metabolic process" NARROW []
synonym: "negative regulation of steroid metabolism" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
relationship: negatively_regulates GO:0008202 ! steroid metabolic process

[Term]
id: GO:0045940
name: positive regulation of steroid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of steroid metabolic process" NARROW []
synonym: "positive regulation of steroid metabolism" EXACT []
synonym: "stimulation of steroid metabolic process" NARROW []
synonym: "up regulation of steroid metabolic process" EXACT []
synonym: "up-regulation of steroid metabolic process" EXACT []
synonym: "upregulation of steroid metabolic process" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
relationship: positively_regulates GO:0008202 ! steroid metabolic process

[Term]
id: GO:0045941
name: positive regulation of transcription
namespace: biological_process
alt_id: GO:0061020
def: "Any cellular process that activates or increases the frequency, rate or extent of transcription." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of transcription" NARROW []
synonym: "positive regulation of cellular transcription" EXACT []
synonym: "stimulation of transcription" NARROW []
synonym: "up regulation of transcription" EXACT []
synonym: "up-regulation of transcription" EXACT []
synonym: "upregulation of transcription" EXACT []
xref: Reactome:163765 "ChREBP activates metabolic gene expression"
xref: Reactome:449105 "ChREBP activates metabolic gene expression"
xref: Reactome:470217 "ChREBP activates metabolic gene expression"
xref: Reactome:487903 "ChREBP activates metabolic gene expression"
xref: Reactome:507870 "ChREBP activates metabolic gene expression"
xref: Reactome:517769 "ChREBP activates metabolic gene expression"
xref: Reactome:526602 "ChREBP activates metabolic gene expression"
xref: Reactome:531509 "ChREBP activates metabolic gene expression"
xref: Reactome:536900 "ChREBP activates metabolic gene expression"
xref: Reactome:542648 "ChREBP activates metabolic gene expression"
xref: Reactome:547963 "ChREBP activates metabolic gene expression"
xref: Reactome:552533 "ChREBP activates metabolic gene expression"
xref: Reactome:558161 "ChREBP activates metabolic gene expression"
xref: Reactome:568790 "ChREBP activates metabolic gene expression"
xref: Reactome:581993 "ChREBP activates metabolic gene expression"
xref: Reactome:586040 "ChREBP activates metabolic gene expression"
xref: Reactome:592900 "ChREBP activates metabolic gene expression"
xref: Reactome:595594 "ChREBP activates metabolic gene expression"
xref: Reactome:597454 "ChREBP activates metabolic gene expression"
xref: Reactome:598220 "ChREBP activates metabolic gene expression"
xref: Reactome:599785 "ChREBP activates metabolic gene expression"
xref: Reactome:600701 "ChREBP activates metabolic gene expression"
xref: Reactome:602624 "ChREBP activates metabolic gene expression"
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0010628 ! positive regulation of gene expression
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0045449 ! regulation of transcription
is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
relationship: positively_regulates GO:0006350 ! transcription

[Term]
id: GO:0045942
name: negative regulation of phosphorus utilization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphorus utilization." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of phosphorus utilization" EXACT []
synonym: "down-regulation of phosphorus utilization" EXACT []
synonym: "downregulation of phosphorus utilization" EXACT []
synonym: "inhibition of phosphorus utilization" NARROW []
is_a: GO:0006795 ! regulation of phosphorus utilization
is_a: GO:0010563 ! negative regulation of phosphorus metabolic process
relationship: negatively_regulates GO:0006794 ! phosphorus utilization

[Term]
id: GO:0045943
name: positive regulation of transcription from RNA polymerase I promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase I promoter." [GOC:go_curators]
synonym: "activation of transcription from RNA polymerase I promoter" NARROW []
synonym: "positive regulation of transcription from Pol I promoter" EXACT []
synonym: "stimulation of transcription from RNA polymerase I promoter" NARROW []
synonym: "up regulation of transcription from RNA polymerase I promoter" EXACT []
synonym: "up-regulation of transcription from RNA polymerase I promoter" EXACT []
synonym: "upregulation of transcription from RNA polymerase I promoter" EXACT []
is_a: GO:0006356 ! regulation of transcription from RNA polymerase I promoter
is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent
relationship: positively_regulates GO:0006360 ! transcription from RNA polymerase I promoter

[Term]
id: GO:0045944
name: positive regulation of transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase II promoter." [GOC:go_curators]
synonym: "activation of transcription from RNA polymerase II promoter" NARROW []
synonym: "positive regulation of transcription from Pol II promoter" EXACT []
synonym: "stimulation of transcription from RNA polymerase II promoter" NARROW []
synonym: "up regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "up-regulation of transcription from RNA polymerase II promoter" EXACT []
synonym: "upregulation of transcription from RNA polymerase II promoter" EXACT []
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent
relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter

[Term]
id: GO:0045945
name: positive regulation of transcription from RNA polymerase III promoter
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from the RNA polymerase III promoter." [GOC:go_curators]
synonym: "activation of transcription from RNA polymerase III promoter" NARROW []
synonym: "positive regulation of transcription from Pol III promoter" EXACT []
synonym: "stimulation of transcription from RNA polymerase III promoter" NARROW []
synonym: "up regulation of transcription from RNA polymerase III promoter" EXACT []
synonym: "up-regulation of transcription from RNA polymerase III promoter" EXACT []
synonym: "upregulation of transcription from RNA polymerase III promoter" EXACT []
is_a: GO:0006359 ! regulation of transcription from RNA polymerase III promoter
is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent
relationship: positively_regulates GO:0006383 ! transcription from RNA polymerase III promoter

[Term]
id: GO:0045947
name: negative regulation of translational initiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of translational initiation" EXACT []
synonym: "down-regulation of translational initiation" EXACT []
synonym: "downregulation of translational initiation" EXACT []
synonym: "inhibition of translational initiation" NARROW []
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0017148 ! negative regulation of translation
relationship: negatively_regulates GO:0006413 ! translational initiation

[Term]
id: GO:0045948
name: positive regulation of translational initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of translational initiation" NARROW []
synonym: "stimulation of translational initiation" NARROW []
synonym: "up regulation of translational initiation" EXACT []
synonym: "up-regulation of translational initiation" EXACT []
synonym: "upregulation of translational initiation" EXACT []
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0045727 ! positive regulation of translation
relationship: positively_regulates GO:0006413 ! translational initiation

[Term]
id: GO:0045949
name: positive regulation of phosphorus utilization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phosphorus utilization." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of phosphorus utilization" NARROW []
synonym: "stimulation of phosphorus utilization" NARROW []
synonym: "up regulation of phosphorus utilization" EXACT []
synonym: "up-regulation of phosphorus utilization" EXACT []
synonym: "upregulation of phosphorus utilization" EXACT []
is_a: GO:0006795 ! regulation of phosphorus utilization
is_a: GO:0010562 ! positive regulation of phosphorus metabolic process
relationship: positively_regulates GO:0006794 ! phosphorus utilization

[Term]
id: GO:0045950
name: negative regulation of mitotic recombination
namespace: biological_process
def: "Any process that inhibits or decreases the rate of DNA recombination during mitosis." [GOC:go_curators, GOC:hjd]
synonym: "down regulation of mitotic recombination" EXACT []
synonym: "down-regulation of mitotic recombination" EXACT []
synonym: "downregulation of mitotic recombination" EXACT []
synonym: "inhibition of mitotic recombination" NARROW []
synonym: "negative regulation of recombination within rDNA repeats" NARROW []
is_a: GO:0000019 ! regulation of mitotic recombination
is_a: GO:0045910 ! negative regulation of DNA recombination
relationship: negatively_regulates GO:0006312 ! mitotic recombination

[Term]
id: GO:0045951
name: positive regulation of mitotic recombination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators]
synonym: "activation of mitotic recombination" NARROW []
synonym: "positive regulation of recombination within rDNA repeats" NARROW []
synonym: "stimulation of mitotic recombination" NARROW []
synonym: "up regulation of mitotic recombination" EXACT []
synonym: "up-regulation of mitotic recombination" EXACT []
synonym: "upregulation of mitotic recombination" EXACT []
is_a: GO:0000019 ! regulation of mitotic recombination
is_a: GO:0045911 ! positive regulation of DNA recombination
relationship: positively_regulates GO:0006312 ! mitotic recombination

[Term]
id: GO:0045952
name: regulation of juvenile hormone catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators]
synonym: "regulation of juvenile hormone breakdown" EXACT []
synonym: "regulation of juvenile hormone catabolism" EXACT []
synonym: "regulation of juvenile hormone degradation" EXACT []
is_a: GO:0007556 ! regulation of juvenile hormone metabolic process
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
relationship: regulates GO:0006719 ! juvenile hormone catabolic process

[Term]
id: GO:0045953
name: negative regulation of natural killer cell mediated cytotoxicity
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "down regulation of natural killer cell mediated cytotoxicity" EXACT []
synonym: "down-regulation of natural killer cell mediated cytotoxicity" EXACT []
synonym: "downregulation of natural killer cell mediated cytotoxicity" EXACT []
synonym: "inhibition of natural killer cell mediated cytotoxicity" NARROW []
synonym: "negative regulation of natural killer cell mediated cell death" EXACT []
synonym: "negative regulation of natural killer cell mediated cell killing" EXACT []
synonym: "negative regulation of natural killer cell mediated cytolysis" RELATED []
synonym: "negative regulation of NK cell mediated cell death" EXACT []
synonym: "negative regulation of NK cell mediated cell killing" EXACT []
synonym: "negative regulation of NK cell mediated cytolysis" RELATED []
synonym: "negative regulation of NK cell mediated cytotoxicity" EXACT []
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity
is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity
relationship: negatively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity

[Term]
id: GO:0045954
name: positive regulation of natural killer cell mediated cytotoxicity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "activation of natural killer cell mediated cytotoxicity" NARROW []
synonym: "positive regulation of natural killer cell mediated cell death" EXACT []
synonym: "positive regulation of natural killer cell mediated cell killing" EXACT []
synonym: "positive regulation of natural killer cell mediated cytolysis" RELATED []
synonym: "positive regulation of NK cell mediated cell death" EXACT []
synonym: "positive regulation of NK cell mediated cell killing" EXACT []
synonym: "positive regulation of NK cell mediated cytolysis" RELATED []
synonym: "positive regulation of NK cell mediated cytotoxicity" EXACT []
synonym: "stimulation of natural killer cell mediated cytotoxicity" NARROW []
synonym: "up regulation of natural killer cell mediated cytotoxicity" EXACT []
synonym: "up-regulation of natural killer cell mediated cytotoxicity" EXACT []
synonym: "upregulation of natural killer cell mediated cytotoxicity" EXACT []
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity
is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity
relationship: positively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity

[Term]
id: GO:0045955
name: negative regulation of calcium ion-dependent exocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]
synonym: "down regulation of calcium ion-dependent exocytosis" EXACT []
synonym: "down-regulation of calcium ion-dependent exocytosis" EXACT []
synonym: "downregulation of calcium ion-dependent exocytosis" EXACT []
synonym: "inhibition of calcium ion-dependent exocytosis" NARROW []
is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis
is_a: GO:0045920 ! negative regulation of exocytosis
relationship: negatively_regulates GO:0017156 ! calcium ion-dependent exocytosis

[Term]
id: GO:0045956
name: positive regulation of calcium ion-dependent exocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]
synonym: "activation of calcium ion-dependent exocytosis" NARROW []
synonym: "stimulation of calcium ion-dependent exocytosis" NARROW []
synonym: "up regulation of calcium ion-dependent exocytosis" EXACT []
synonym: "up-regulation of calcium ion-dependent exocytosis" EXACT []
synonym: "upregulation of calcium ion-dependent exocytosis" EXACT []
is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis
is_a: GO:0045921 ! positive regulation of exocytosis
relationship: positively_regulates GO:0017156 ! calcium ion-dependent exocytosis

[Term]
id: GO:0045957
name: negative regulation of complement activation, alternative pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of complement activation by the alternative pathway." [GOC:go_curators]
synonym: "down regulation of complement activation, alternative pathway" EXACT []
synonym: "down-regulation of complement activation, alternative pathway" EXACT []
synonym: "downregulation of complement activation, alternative pathway" EXACT []
synonym: "inhibition of complement activation, alternative pathway" NARROW []
is_a: GO:0030451 ! regulation of complement activation, alternative pathway
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0045916 ! negative regulation of complement activation
relationship: negatively_regulates GO:0006957 ! complement activation, alternative pathway

[Term]
id: GO:0045958
name: positive regulation of complement activation, alternative pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway." [GOC:go_curators]
synonym: "activation of complement activation, alternative pathway" NARROW []
synonym: "stimulation of complement activation, alternative pathway" NARROW []
synonym: "up regulation of complement activation, alternative pathway" EXACT []
synonym: "up-regulation of complement activation, alternative pathway" EXACT []
synonym: "upregulation of complement activation, alternative pathway" EXACT []
is_a: GO:0030451 ! regulation of complement activation, alternative pathway
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0045917 ! positive regulation of complement activation
relationship: positively_regulates GO:0006957 ! complement activation, alternative pathway

[Term]
id: GO:0045959
name: negative regulation of complement activation, classical pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of complement activation by the classical pathway." [GOC:go_curators]
synonym: "down regulation of complement activation, classical pathway" EXACT []
synonym: "down-regulation of complement activation, classical pathway" EXACT []
synonym: "downregulation of complement activation, classical pathway" EXACT []
synonym: "inhibition of complement activation, classical pathway" NARROW []
is_a: GO:0030450 ! regulation of complement activation, classical pathway
is_a: GO:0045916 ! negative regulation of complement activation
relationship: negatively_regulates GO:0006958 ! complement activation, classical pathway

[Term]
id: GO:0045960
name: positive regulation of complement activation, classical pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway." [GOC:go_curators]
synonym: "activation of complement activation, classical pathway" NARROW []
synonym: "stimulation of complement activation, classical pathway" NARROW []
synonym: "up regulation of complement activation, classical pathway" EXACT []
synonym: "up-regulation of complement activation, classical pathway" EXACT []
synonym: "upregulation of complement activation, classical pathway" EXACT []
is_a: GO:0030450 ! regulation of complement activation, classical pathway
is_a: GO:0045917 ! positive regulation of complement activation
relationship: positively_regulates GO:0006958 ! complement activation, classical pathway

[Term]
id: GO:0045961
name: negative regulation of development, heterochronic
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the progression an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition at a consistent predetermined time point during its development." [GOC:go_curators]
synonym: "down regulation of development, heterochronic" EXACT []
synonym: "down-regulation of development, heterochronic" EXACT []
synonym: "downregulation of development, heterochronic" EXACT []
synonym: "inhibition of development, heterochronic" NARROW []
is_a: GO:0040034 ! regulation of development, heterochronic

[Term]
id: GO:0045962
name: positive regulation of development, heterochronic
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the progression an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition at a consistent predetermined time point during its development." [GOC:go_curators]
synonym: "activation of development, heterochronic" NARROW []
synonym: "stimulation of development, heterochronic" NARROW []
synonym: "up regulation of development, heterochronic" EXACT []
synonym: "up-regulation of development, heterochronic" EXACT []
synonym: "upregulation of development, heterochronic" EXACT []
is_a: GO:0040034 ! regulation of development, heterochronic

[Term]
id: GO:0045963
name: negative regulation of dopamine metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators]
synonym: "down regulation of dopamine metabolic process" EXACT []
synonym: "down-regulation of dopamine metabolic process" EXACT []
synonym: "downregulation of dopamine metabolic process" EXACT []
synonym: "inhibition of dopamine metabolic process" NARROW []
synonym: "negative regulation of dopamine metabolism" EXACT []
is_a: GO:0042053 ! regulation of dopamine metabolic process
is_a: GO:0045914 ! negative regulation of catecholamine metabolic process
relationship: negatively_regulates GO:0042417 ! dopamine metabolic process

[Term]
id: GO:0045964
name: positive regulation of dopamine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators]
synonym: "activation of dopamine metabolic process" NARROW []
synonym: "positive regulation of dopamine metabolism" EXACT []
synonym: "stimulation of dopamine metabolic process" NARROW []
synonym: "up regulation of dopamine metabolic process" EXACT []
synonym: "up-regulation of dopamine metabolic process" EXACT []
synonym: "upregulation of dopamine metabolic process" EXACT []
is_a: GO:0042053 ! regulation of dopamine metabolic process
is_a: GO:0045915 ! positive regulation of catecholamine metabolic process
relationship: positively_regulates GO:0042417 ! dopamine metabolic process

[Term]
id: GO:0045965
name: negative regulation of ecdysteroid metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids." [GOC:go_curators]
synonym: "down regulation of ecdysteroid metabolic process" EXACT []
synonym: "down-regulation of ecdysteroid metabolic process" EXACT []
synonym: "downregulation of ecdysteroid metabolic process" EXACT []
synonym: "inhibition of ecdysteroid metabolic process" NARROW []
synonym: "negative regulation of ecdysteroid metabolism" EXACT []
is_a: GO:0007553 ! regulation of ecdysteroid metabolic process
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0045939 ! negative regulation of steroid metabolic process
relationship: negatively_regulates GO:0045455 ! ecdysteroid metabolic process

[Term]
id: GO:0045966
name: positive regulation of ecdysteroid metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids." [GOC:go_curators]
synonym: "activation of ecdysteroid metabolic process" NARROW []
synonym: "positive regulation of ecdysteroid metabolism" EXACT []
synonym: "stimulation of ecdysteroid metabolic process" NARROW []
synonym: "up regulation of ecdysteroid metabolic process" EXACT []
synonym: "up-regulation of ecdysteroid metabolic process" EXACT []
synonym: "upregulation of ecdysteroid metabolic process" EXACT []
is_a: GO:0007553 ! regulation of ecdysteroid metabolic process
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0045940 ! positive regulation of steroid metabolic process
relationship: positively_regulates GO:0045455 ! ecdysteroid metabolic process

[Term]
id: GO:0045967
name: negative regulation of growth rate
namespace: biological_process
def: "Any process that reduces the rate of growth of all or part of an organism." [GOC:mah]
comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation.
synonym: "down regulation of growth rate" EXACT []
synonym: "down-regulation of growth rate" EXACT []
synonym: "downregulation of growth rate" EXACT []
synonym: "inhibition of growth rate" NARROW []
is_a: GO:0040009 ! regulation of growth rate
is_a: GO:0045926 ! negative regulation of growth

[Term]
id: GO:0045968
name: negative regulation of juvenile hormone biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators]
synonym: "down regulation of juvenile hormone biosynthetic process" EXACT []
synonym: "down-regulation of juvenile hormone biosynthetic process" EXACT []
synonym: "downregulation of juvenile hormone biosynthetic process" EXACT []
synonym: "inhibition of juvenile hormone biosynthetic process" NARROW []
synonym: "negative regulation of juvenile hormone anabolism" EXACT []
synonym: "negative regulation of juvenile hormone biosynthesis" EXACT []
synonym: "negative regulation of juvenile hormone formation" EXACT []
synonym: "negative regulation of juvenile hormone synthesis" EXACT []
is_a: GO:0007557 ! regulation of juvenile hormone biosynthetic process
is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
is_a: GO:0045928 ! negative regulation of juvenile hormone metabolic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
relationship: negatively_regulates GO:0006718 ! juvenile hormone biosynthetic process

[Term]
id: GO:0045969
name: positive regulation of juvenile hormone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators]
synonym: "activation of juvenile hormone biosynthetic process" NARROW []
synonym: "positive regulation of juvenile hormone anabolism" EXACT []
synonym: "positive regulation of juvenile hormone biosynthesis" EXACT []
synonym: "positive regulation of juvenile hormone formation" EXACT []
synonym: "positive regulation of juvenile hormone synthesis" EXACT []
synonym: "stimulation of juvenile hormone biosynthetic process" NARROW []
synonym: "up regulation of juvenile hormone biosynthetic process" EXACT []
synonym: "up-regulation of juvenile hormone biosynthetic process" EXACT []
synonym: "upregulation of juvenile hormone biosynthetic process" EXACT []
is_a: GO:0007557 ! regulation of juvenile hormone biosynthetic process
is_a: GO:0045929 ! positive regulation of juvenile hormone metabolic process
is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
relationship: positively_regulates GO:0006718 ! juvenile hormone biosynthetic process

[Term]
id: GO:0045970
name: negative regulation of juvenile hormone catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators]
synonym: "down regulation of juvenile hormone catabolic process" EXACT []
synonym: "down-regulation of juvenile hormone catabolic process" EXACT []
synonym: "downregulation of juvenile hormone catabolic process" EXACT []
synonym: "inhibition of juvenile hormone catabolic process" NARROW []
synonym: "negative regulation of juvenile hormone breakdown" EXACT []
synonym: "negative regulation of juvenile hormone catabolism" EXACT []
synonym: "negative regulation of juvenile hormone degradation" EXACT []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0045928 ! negative regulation of juvenile hormone metabolic process
is_a: GO:0045952 ! regulation of juvenile hormone catabolic process
is_a: GO:0050995 ! negative regulation of lipid catabolic process
relationship: negatively_regulates GO:0006719 ! juvenile hormone catabolic process

[Term]
id: GO:0045971
name: positive regulation of juvenile hormone catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators]
synonym: "activation of juvenile hormone catabolic process" NARROW []
synonym: "positive regulation of juvenile hormone breakdown" EXACT []
synonym: "positive regulation of juvenile hormone catabolism" EXACT []
synonym: "positive regulation of juvenile hormone degradation" EXACT []
synonym: "stimulation of juvenile hormone catabolic process" NARROW []
synonym: "up regulation of juvenile hormone catabolic process" EXACT []
synonym: "up-regulation of juvenile hormone catabolic process" EXACT []
synonym: "upregulation of juvenile hormone catabolic process" EXACT []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0045929 ! positive regulation of juvenile hormone metabolic process
is_a: GO:0045952 ! regulation of juvenile hormone catabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
relationship: positively_regulates GO:0006719 ! juvenile hormone catabolic process

[Term]
id: GO:0045972
name: negative regulation of juvenile hormone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of juvenile hormone." [GOC:go_curators]
synonym: "down regulation of juvenile hormone secretion" EXACT []
synonym: "down-regulation of juvenile hormone secretion" EXACT []
synonym: "downregulation of juvenile hormone secretion" EXACT []
synonym: "inhibition of juvenile hormone secretion" NARROW []
is_a: GO:0007558 ! regulation of juvenile hormone secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
relationship: negatively_regulates GO:0045443 ! juvenile hormone secretion

[Term]
id: GO:0045973
name: positive regulation of juvenile hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of juvenile hormone." [GOC:go_curators]
synonym: "activation of juvenile hormone secretion" NARROW []
synonym: "stimulation of juvenile hormone secretion" NARROW []
synonym: "up regulation of juvenile hormone secretion" EXACT []
synonym: "up-regulation of juvenile hormone secretion" EXACT []
synonym: "upregulation of juvenile hormone secretion" EXACT []
is_a: GO:0007558 ! regulation of juvenile hormone secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
relationship: positively_regulates GO:0045443 ! juvenile hormone secretion

[Term]
id: GO:0045974
name: regulation of translation, ncRNA-mediated
namespace: biological_process
def: "Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein." [GOC:dph, GOC:go_curators, GOC:tb]
is_a: GO:0006417 ! regulation of translation

[Term]
id: GO:0045975
name: positive regulation of translation, ncRNA-mediated
namespace: biological_process
def: "Any process, mediated by small non-coding RNAs, that activates or increases the rate that mRNAs are effectively translated into protein." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of mRNA translation, ncRNA-mediated" NARROW []
synonym: "stimulation of mRNA translation, ncRNA-mediated" NARROW []
synonym: "up regulation of mRNA translation, ncRNA-mediated" EXACT []
synonym: "up-regulation of mRNA translation, ncRNA-mediated" EXACT []
synonym: "upregulation of mRNA translation, ncRNA-mediated" EXACT []
is_a: GO:0045727 ! positive regulation of translation
is_a: GO:0045974 ! regulation of translation, ncRNA-mediated

[Term]
id: GO:0045976
name: negative regulation of mitotic cell cycle, embryonic
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through embryonic mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through embryonic mitotic cell cycle" EXACT []
synonym: "downregulation of progression through embryonic mitotic cell cycle" EXACT []
synonym: "inhibition of progression through embryonic mitotic cell cycle" NARROW []
synonym: "negative regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of embryonic mitotic cell cycle progression" EXACT []
synonym: "negative regulation of progression through embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic
is_a: GO:0045930 ! negative regulation of mitotic cell cycle
relationship: negatively_regulates GO:0045448 ! mitotic cell cycle, embryonic

[Term]
id: GO:0045977
name: positive regulation of mitotic cell cycle, embryonic
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of mitotic cell cycle, embryonic" NARROW []
synonym: "positive regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of embryonic mitotic cell cycle progression" EXACT []
synonym: "positive regulation of progression through embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of mitotic cell cycle, embryonic" NARROW []
synonym: "up regulation of mitotic cell cycle, embryonic" EXACT []
synonym: "up-regulation of mitotic cell cycle, embryonic" EXACT []
synonym: "upregulation of mitotic cell cycle, embryonic" EXACT []
is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic
is_a: GO:0045931 ! positive regulation of mitotic cell cycle
relationship: positively_regulates GO:0045448 ! mitotic cell cycle, embryonic

[Term]
id: GO:0045978
name: negative regulation of nucleoside metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of nucleoside metabolic process" EXACT []
synonym: "down-regulation of nucleoside metabolic process" EXACT []
synonym: "downregulation of nucleoside metabolic process" EXACT []
synonym: "inhibition of nucleoside metabolic process" NARROW []
synonym: "negative regulation of nucleoside metabolism" EXACT []
is_a: GO:0009118 ! regulation of nucleoside metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
relationship: negatively_regulates GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0045979
name: positive regulation of nucleoside metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of nucleoside metabolic process" NARROW []
synonym: "positive regulation of nucleoside metabolism" EXACT []
synonym: "stimulation of nucleoside metabolic process" NARROW []
synonym: "up regulation of nucleoside metabolic process" EXACT []
synonym: "up-regulation of nucleoside metabolic process" EXACT []
synonym: "upregulation of nucleoside metabolic process" EXACT []
is_a: GO:0009118 ! regulation of nucleoside metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
relationship: positively_regulates GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0045980
name: negative regulation of nucleotide metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of nucleotide metabolic process" EXACT []
synonym: "down-regulation of nucleotide metabolic process" EXACT []
synonym: "downregulation of nucleotide metabolic process" EXACT []
synonym: "inhibition of nucleotide metabolic process" NARROW []
synonym: "negative regulation of nucleotide metabolism" EXACT []
is_a: GO:0006140 ! regulation of nucleotide metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
relationship: negatively_regulates GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0045981
name: positive regulation of nucleotide metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of nucleotide metabolic process" NARROW []
synonym: "positive regulation of nucleotide metabolism" EXACT []
synonym: "stimulation of nucleotide metabolic process" NARROW []
synonym: "up regulation of nucleotide metabolic process" EXACT []
synonym: "up-regulation of nucleotide metabolic process" EXACT []
synonym: "upregulation of nucleotide metabolic process" EXACT []
is_a: GO:0006140 ! regulation of nucleotide metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
relationship: positively_regulates GO:0009117 ! nucleotide metabolic process

[Term]
id: GO:0045982
name: negative regulation of purine base metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving purine bases." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of purine base metabolic process" EXACT []
synonym: "down-regulation of purine base metabolic process" EXACT []
synonym: "downregulation of purine base metabolic process" EXACT []
synonym: "inhibition of purine base metabolic process" NARROW []
synonym: "negative regulation of purine base metabolism" EXACT []
is_a: GO:0006141 ! regulation of purine base metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
relationship: negatively_regulates GO:0006144 ! purine base metabolic process

[Term]
id: GO:0045983
name: positive regulation of purine base metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving purine bases." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of purine base metabolic process" NARROW []
synonym: "positive regulation of purine base metabolism" EXACT []
synonym: "stimulation of purine base metabolic process" NARROW []
synonym: "up regulation of purine base metabolic process" EXACT []
synonym: "up-regulation of purine base metabolic process" EXACT []
synonym: "upregulation of purine base metabolic process" EXACT []
is_a: GO:0006141 ! regulation of purine base metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
relationship: positively_regulates GO:0006144 ! purine base metabolic process

[Term]
id: GO:0045984
name: negative regulation of pyrimidine base metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine bases." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of pyrimidine base metabolic process" EXACT []
synonym: "down-regulation of pyrimidine base metabolic process" EXACT []
synonym: "downregulation of pyrimidine base metabolic process" EXACT []
synonym: "inhibition of pyrimidine base metabolic process" NARROW []
synonym: "negative regulation of pyrimidine base metabolism" EXACT []
is_a: GO:0006142 ! regulation of pyrimidine base metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
relationship: negatively_regulates GO:0006206 ! pyrimidine base metabolic process

[Term]
id: GO:0045985
name: positive regulation of pyrimidine base metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine bases." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of pyrimidine base metabolic process" NARROW []
synonym: "positive regulation of pyrimidine base metabolism" EXACT []
synonym: "stimulation of pyrimidine base metabolic process" NARROW []
synonym: "up regulation of pyrimidine base metabolic process" EXACT []
synonym: "up-regulation of pyrimidine base metabolic process" EXACT []
synonym: "upregulation of pyrimidine base metabolic process" EXACT []
is_a: GO:0006142 ! regulation of pyrimidine base metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
relationship: positively_regulates GO:0006206 ! pyrimidine base metabolic process

[Term]
id: GO:0045986
name: negative regulation of smooth muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]
synonym: "down regulation of smooth muscle contraction" EXACT []
synonym: "down-regulation of smooth muscle contraction" EXACT []
synonym: "downregulation of smooth muscle contraction" EXACT []
synonym: "inhibition of smooth muscle contraction" NARROW []
synonym: "smooth muscle relaxation" RELATED []
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0045932 ! negative regulation of muscle contraction
relationship: negatively_regulates GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0045987
name: positive regulation of smooth muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators]
synonym: "activation of smooth muscle contraction" NARROW []
synonym: "stimulation of smooth muscle contraction" NARROW []
synonym: "up regulation of smooth muscle contraction" EXACT []
synonym: "up-regulation of smooth muscle contraction" EXACT []
synonym: "upregulation of smooth muscle contraction" EXACT []
is_a: GO:0006940 ! regulation of smooth muscle contraction
is_a: GO:0045933 ! positive regulation of muscle contraction
relationship: positively_regulates GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0045988
name: negative regulation of striated muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of striated muscle contraction." [GOC:go_curators]
synonym: "down regulation of striated muscle contraction" EXACT []
synonym: "down-regulation of striated muscle contraction" EXACT []
synonym: "downregulation of striated muscle contraction" EXACT []
synonym: "inhibition of striated muscle contraction" NARROW []
is_a: GO:0006942 ! regulation of striated muscle contraction
is_a: GO:0045932 ! negative regulation of muscle contraction
relationship: negatively_regulates GO:0006941 ! striated muscle contraction

[Term]
id: GO:0045989
name: positive regulation of striated muscle contraction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of striated muscle contraction." [GOC:go_curators]
synonym: "activation of striated muscle contraction" NARROW []
synonym: "stimulation of striated muscle contraction" NARROW []
synonym: "up regulation of striated muscle contraction" EXACT []
synonym: "up-regulation of striated muscle contraction" EXACT []
synonym: "upregulation of striated muscle contraction" EXACT []
is_a: GO:0006942 ! regulation of striated muscle contraction
is_a: GO:0045933 ! positive regulation of muscle contraction
relationship: positively_regulates GO:0006941 ! striated muscle contraction

[Term]
id: GO:0045990
name: regulation of transcription by carbon catabolites
namespace: biological_process
def: "Any process involving carbon catabolites that modulates the frequency, rate or extent of transcription." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006355 ! regulation of transcription, DNA-dependent
is_a: GO:0031670 ! cellular response to nutrient

[Term]
id: GO:0045991
name: positive regulation of transcription by carbon catabolites
namespace: biological_process
def: "Any process involving carbon catabolites that activates or increases the rate of transcription." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of transcription by carbon catabolites" NARROW []
synonym: "stimulation of transcription by carbon catabolites" NARROW []
synonym: "up regulation of transcription by carbon catabolites" EXACT []
synonym: "up-regulation of transcription by carbon catabolites" EXACT []
synonym: "upregulation of transcription by carbon catabolites" EXACT []
is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent
is_a: GO:0045990 ! regulation of transcription by carbon catabolites

[Term]
id: GO:0045992
name: negative regulation of embryonic development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic development." [GOC:go_curators]
synonym: "down regulation of embryonic development" EXACT []
synonym: "down-regulation of embryonic development" EXACT []
synonym: "downregulation of embryonic development" EXACT []
synonym: "inhibition of embryonic development" NARROW []
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0009790 ! embryonic development

[Term]
id: GO:0045993
name: negative regulation of translational initiation by iron
namespace: biological_process
def: "Any process involving iron that stops, prevents or reduces the rate of translational initiation." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of translational initiation by iron" EXACT []
synonym: "down-regulation of translational initiation by iron" EXACT []
synonym: "downregulation of translational initiation by iron" EXACT []
synonym: "inhibition of translational initiation by iron" NARROW []
is_a: GO:0006447 ! regulation of translational initiation by iron
is_a: GO:0045947 ! negative regulation of translational initiation

[Term]
id: GO:0045994
name: positive regulation of translational initiation by iron
namespace: biological_process
def: "Any process involving iron that activates or increases the rate of translational initiation." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of translational initiation by iron" NARROW []
synonym: "stimulation of translational initiation by iron" NARROW []
synonym: "up regulation of translational initiation by iron" EXACT []
synonym: "up-regulation of translational initiation by iron" EXACT []
synonym: "upregulation of translational initiation by iron" EXACT []
is_a: GO:0006447 ! regulation of translational initiation by iron
is_a: GO:0045948 ! positive regulation of translational initiation

[Term]
id: GO:0045995
name: regulation of embryonic development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0009790 ! embryonic development

[Term]
id: GO:0045996
name: negative regulation of transcription by pheromones
namespace: biological_process
def: "Any process involving pheromones that stops, prevents or reduces the rate of transcription." [GOC:go_curators]
subset: gosubset_prok
synonym: "down regulation of transcription by pheromones" EXACT []
synonym: "down-regulation of transcription by pheromones" EXACT []
synonym: "downregulation of transcription by pheromones" EXACT []
synonym: "inhibition of transcription by pheromones" NARROW []
is_a: GO:0009373 ! regulation of transcription by pheromones
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent

[Term]
id: GO:0045997
name: negative regulation of ecdysteroid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators]
synonym: "down regulation of ecdysteroid biosynthetic process" EXACT []
synonym: "down-regulation of ecdysteroid biosynthetic process" EXACT []
synonym: "downregulation of ecdysteroid biosynthetic process" EXACT []
synonym: "inhibition of ecdysteroid biosynthetic process" NARROW []
synonym: "negative regulation of ecdysteroid anabolism" EXACT []
synonym: "negative regulation of ecdysteroid biosynthesis" EXACT []
synonym: "negative regulation of ecdysteroid formation" EXACT []
synonym: "negative regulation of ecdysteroid synthesis" EXACT []
is_a: GO:0007554 ! regulation of ecdysteroid biosynthetic process
is_a: GO:0045965 ! negative regulation of ecdysteroid metabolic process
is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process
relationship: negatively_regulates GO:0045456 ! ecdysteroid biosynthetic process

[Term]
id: GO:0045998
name: positive regulation of ecdysteroid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators]
synonym: "activation of ecdysteroid biosynthetic process" NARROW []
synonym: "positive regulation of ecdysteroid anabolism" EXACT []
synonym: "positive regulation of ecdysteroid biosynthesis" EXACT []
synonym: "positive regulation of ecdysteroid formation" EXACT []
synonym: "positive regulation of ecdysteroid synthesis" EXACT []
synonym: "stimulation of ecdysteroid biosynthetic process" NARROW []
synonym: "up regulation of ecdysteroid biosynthetic process" EXACT []
synonym: "up-regulation of ecdysteroid biosynthetic process" EXACT []
synonym: "upregulation of ecdysteroid biosynthetic process" EXACT []
is_a: GO:0007554 ! regulation of ecdysteroid biosynthetic process
is_a: GO:0045966 ! positive regulation of ecdysteroid metabolic process
is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process
relationship: positively_regulates GO:0045456 ! ecdysteroid biosynthetic process

[Term]
id: GO:0045999
name: negative regulation of ecdysteroid secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of ecdysteroid." [GOC:go_curators]
synonym: "down regulation of ecdysteroid secretion" EXACT []
synonym: "down-regulation of ecdysteroid secretion" EXACT []
synonym: "downregulation of ecdysteroid secretion" EXACT []
synonym: "inhibition of ecdysteroid secretion" NARROW []
is_a: GO:0007555 ! regulation of ecdysteroid secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
relationship: negatively_regulates GO:0045457 ! ecdysteroid secretion

[Term]
id: GO:0046000
name: positive regulation of ecdysteroid secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of ecdysteroid." [GOC:go_curators]
synonym: "activation of ecdysteroid secretion" NARROW []
synonym: "stimulation of ecdysteroid secretion" NARROW []
synonym: "up regulation of ecdysteroid secretion" EXACT []
synonym: "up-regulation of ecdysteroid secretion" EXACT []
synonym: "upregulation of ecdysteroid secretion" EXACT []
is_a: GO:0007555 ! regulation of ecdysteroid secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
relationship: positively_regulates GO:0045457 ! ecdysteroid secretion

[Term]
id: GO:0046001
name: negative regulation of preblastoderm mitotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "downregulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "inhibition of progression through preblastoderm mitotic cell cycle" NARROW []
synonym: "negative regulation of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "negative regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007347 ! regulation of preblastoderm mitotic cell cycle
is_a: GO:0045976 ! negative regulation of mitotic cell cycle, embryonic
relationship: negatively_regulates GO:0035185 ! preblastoderm mitotic cell cycle

[Term]
id: GO:0046002
name: positive regulation of preblastoderm mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of progression through preblastoderm mitotic cell cycle" NARROW []
synonym: "positive regulation of preblastoderm mitotic cell cycle progression" EXACT []
synonym: "positive regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through preblastoderm mitotic cell cycle" NARROW []
synonym: "up regulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "up-regulation of progression through preblastoderm mitotic cell cycle" EXACT []
synonym: "upregulation of progression through preblastoderm mitotic cell cycle" EXACT []
is_a: GO:0007347 ! regulation of preblastoderm mitotic cell cycle
is_a: GO:0045977 ! positive regulation of mitotic cell cycle, embryonic
relationship: positively_regulates GO:0035185 ! preblastoderm mitotic cell cycle

[Term]
id: GO:0046003
name: negative regulation of syncytial blastoderm mitotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "down regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "down-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "downregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "inhibition of progression through syncytial blastoderm mitotic cell cycle" NARROW []
synonym: "negative regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of syncytial blastoderm cell cycle progression" EXACT []
is_a: GO:0007348 ! regulation of syncytial blastoderm mitotic cell cycle
is_a: GO:0045976 ! negative regulation of mitotic cell cycle, embryonic
relationship: negatively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle

[Term]
id: GO:0046004
name: positive regulation of syncytial blastoderm mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb]
synonym: "activation of progression through syncytial blastoderm mitotic cell cycle" NARROW []
synonym: "positive regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "positive regulation of syncytial blastoderm cell cycle progression" EXACT []
synonym: "stimulation of progression through syncytial blastoderm mitotic cell cycle" NARROW []
synonym: "up regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "up-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
synonym: "upregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT []
is_a: GO:0007348 ! regulation of syncytial blastoderm mitotic cell cycle
is_a: GO:0045977 ! positive regulation of mitotic cell cycle, embryonic
relationship: positively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle

[Term]
id: GO:0046005
name: positive regulation of circadian sleep/wake cycle, REM sleep
namespace: biological_process
def: "Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators]
synonym: "activation of circadian sleep/wake cycle, REM sleep" NARROW []
synonym: "positive regulation of REM sleep" EXACT []
synonym: "stimulation of circadian sleep/wake cycle, REM sleep" NARROW []
synonym: "up regulation of circadian sleep/wake cycle, REM sleep" EXACT []
synonym: "up-regulation of circadian sleep/wake cycle, REM sleep" EXACT []
synonym: "upregulation of circadian sleep/wake cycle, REM sleep" EXACT []
is_a: GO:0042320 ! regulation of circadian sleep/wake cycle, REM sleep
is_a: GO:0045938 ! positive regulation of circadian sleep/wake cycle, sleep
relationship: positively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep

[Term]
id: GO:0046006
name: regulation of activated T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of activated T cell proliferation." [GOC:go_curators]
synonym: "regulation of activated T lymphocyte proliferation" EXACT []
synonym: "regulation of activated T-cell proliferation" EXACT []
synonym: "regulation of activated T-lymphocyte proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
relationship: regulates GO:0050798 ! activated T cell proliferation

[Term]
id: GO:0046007
name: negative regulation of activated T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation." [GOC:go_curators]
synonym: "down regulation of activated T cell proliferation" EXACT []
synonym: "down-regulation of activated T cell proliferation" EXACT []
synonym: "downregulation of activated T cell proliferation" EXACT []
synonym: "inhibition of activated T cell proliferation" NARROW []
synonym: "negative regulation of activated T lymphocyte proliferation" EXACT []
synonym: "negative regulation of activated T-cell proliferation" EXACT []
synonym: "negative regulation of activated T-lymphocyte proliferation" EXACT []
is_a: GO:0042130 ! negative regulation of T cell proliferation
is_a: GO:0046006 ! regulation of activated T cell proliferation
relationship: negatively_regulates GO:0050798 ! activated T cell proliferation

[Term]
id: GO:0046008
name: regulation of female receptivity, post-mating
namespace: biological_process
def: "Any process that modulates the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators]
is_a: GO:0045297 ! post-mating behavior
is_a: GO:0045924 ! regulation of female receptivity

[Term]
id: GO:0046009
name: positive regulation of female receptivity, post-mating
namespace: biological_process
def: "Any process that increases the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators]
synonym: "activation of female receptivity, post-mating" NARROW []
synonym: "stimulation of female receptivity, post-mating" NARROW []
synonym: "up regulation of female receptivity, post-mating" EXACT []
synonym: "up-regulation of female receptivity, post-mating" EXACT []
synonym: "upregulation of female receptivity, post-mating" EXACT []
is_a: GO:0045925 ! positive regulation of female receptivity
is_a: GO:0046008 ! regulation of female receptivity, post-mating

[Term]
id: GO:0046010
name: positive regulation of circadian sleep/wake cycle, non-REM sleep
namespace: biological_process
def: "Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:go_curators]
synonym: "activation of circadian sleep/wake cycle, non-REM sleep" NARROW []
synonym: "positive regulation of non-REM sleep" EXACT []
synonym: "stimulation of circadian sleep/wake cycle, non-REM sleep" NARROW []
synonym: "up regulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
synonym: "up-regulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
synonym: "upregulation of circadian sleep/wake cycle, non-REM sleep" EXACT []
is_a: GO:0045188 ! regulation of circadian sleep/wake cycle, non-REM sleep
is_a: GO:0045938 ! positive regulation of circadian sleep/wake cycle, sleep
relationship: positively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep

[Term]
id: GO:0046011
name: regulation of oskar mRNA translation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512]
is_a: GO:0006417 ! regulation of translation

[Term]
id: GO:0046012
name: positive regulation of oskar mRNA translation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oskar mRNA translation." [GOC:go_curators]
synonym: "activation of oskar mRNA translation" NARROW []
synonym: "stimulation of oskar mRNA translation" NARROW []
synonym: "up regulation of oskar mRNA translation" EXACT []
synonym: "up-regulation of oskar mRNA translation" EXACT []
synonym: "upregulation of oskar mRNA translation" EXACT []
is_a: GO:0045727 ! positive regulation of translation
is_a: GO:0046011 ! regulation of oskar mRNA translation

[Term]
id: GO:0046013
name: regulation of T cell homeostatic proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of resting T cell proliferation." [GOC:go_curators]
synonym: "regulation of resting T cell proliferation" EXACT []
synonym: "regulation of T lymphocyte homeostatic proliferation" EXACT []
synonym: "regulation of T-cell homeostatic proliferation" EXACT []
synonym: "regulation of T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0042129 ! regulation of T cell proliferation
relationship: regulates GO:0001777 ! T cell homeostatic proliferation

[Term]
id: GO:0046014
name: negative regulation of T cell homeostatic proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation." [GOC:go_curators]
synonym: "down regulation of T cell homeostatic proliferation" EXACT []
synonym: "down-regulation of T cell homeostatic proliferation" EXACT []
synonym: "downregulation of T cell homeostatic proliferation" EXACT []
synonym: "inhibition of T cell homeostatic proliferation" NARROW []
synonym: "negative regulation of resting T cell proliferation" EXACT []
synonym: "negative regulation of T lymphocyte homeostatic proliferation" EXACT []
synonym: "negative regulation of T-cell homeostatic proliferation" EXACT []
synonym: "negative regulation of T-lymphocyte homeostatic proliferation" EXACT []
is_a: GO:0042130 ! negative regulation of T cell proliferation
is_a: GO:0046013 ! regulation of T cell homeostatic proliferation
relationship: negatively_regulates GO:0001777 ! T cell homeostatic proliferation

[Term]
id: GO:0046015
name: regulation of transcription by glucose
namespace: biological_process
def: "Any process involving glucose that modulates the frequency, rate or extent or transcription." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0045990 ! regulation of transcription by carbon catabolites

[Term]
id: GO:0046016
name: positive regulation of transcription by glucose
namespace: biological_process
def: "Any process involving glucose that activates or increases the rate of transcription." [GOC:go_curators]
subset: gosubset_prok
synonym: "activation of transcription by glucose" NARROW []
synonym: "stimulation of transcription by glucose" NARROW []
synonym: "up regulation of transcription by glucose" EXACT []
synonym: "up-regulation of transcription by glucose" EXACT []
synonym: "upregulation of transcription by glucose" EXACT []
is_a: GO:0045991 ! positive regulation of transcription by carbon catabolites
is_a: GO:0046015 ! regulation of transcription by glucose

[Term]
id: GO:0046017
name: regulation of transcription from RNA polymerase I promoter, mitotic
namespace: biological_process
def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators]
synonym: "mitotic regulation of transcription from Pol I promoter" EXACT []
synonym: "regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006356 ! regulation of transcription from RNA polymerase I promoter
is_a: GO:0045896 ! regulation of transcription, mitotic

[Term]
id: GO:0046018
name: positive regulation of transcription from RNA polymerase I promoter, mitotic
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators]
synonym: "activation of transcription from RNA polymerase I promoter, mitotic" NARROW []
synonym: "mitotic activation of transcription from Pol I promoter" EXACT []
synonym: "positive regulation of transcription from Pol I promoter, mitotic" EXACT []
synonym: "positive regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of transcription from RNA polymerase I promoter, mitotic" NARROW []
synonym: "up regulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
synonym: "up-regulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
synonym: "upregulation of transcription from RNA polymerase I promoter, mitotic" EXACT []
is_a: GO:0045897 ! positive regulation of transcription, mitotic
is_a: GO:0045943 ! positive regulation of transcription from RNA polymerase I promoter
is_a: GO:0046017 ! regulation of transcription from RNA polymerase I promoter, mitotic

[Term]
id: GO:0046019
name: regulation of transcription from RNA polymerase II promoter by pheromones
namespace: biological_process
def: "Any process involving pheromones that modulates the frequency, rate or extent or transcription from the RNA polymerase II promoter." [GOC:go_curators]
synonym: "regulation of transcription from Pol II promoter by pheromones" EXACT []
is_a: GO:0009373 ! regulation of transcription by pheromones
is_a: GO:0010551 ! regulation of gene-specific transcription from RNA polymerase II promoter

[Term]
id: GO:0046020
name: negative regulation of transcription from RNA polymerase II promoter by pheromones
namespace: biological_process
def: "Any process involving pheromones that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators]
synonym: "down regulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
synonym: "down-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
synonym: "downregulation of transcription from RNA polymerase II promoter by pheromones" EXACT []
synonym: "inhibition of transcription from RNA polymerase II promoter by pheromones" NARROW []
synonym: "negative regulation of transcription from Pol II promoter by pheromones" EXACT []
is_a: GO:0010553 ! negative regulation of gene-specific transcription from RNA polymerase II promoter
is_a: GO:0045996 ! negative regulation of transcription by pheromones
is_a: GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones

[Term]
id: GO:0046021
name: regulation of transcription from RNA polymerase II promoter, mitotic
namespace: biological_process
def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators]
synonym: "mitotic regulation of transcription from Pol II promoter" EXACT []
synonym: "regulation of transcription from Pol II promoter, mitotic" EXACT []
synonym: "regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0045896 ! regulation of transcription, mitotic

[Term]
id: GO:0046022
name: positive regulation of transcription from RNA polymerase II promoter, mitotic
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators]
synonym: "activation of transcription from RNA polymerase II promoter, mitotic" NARROW []
synonym: "mitotic activation of transcription from Pol II promoter" EXACT []
synonym: "positive regulation of transcription from Pol II promoter, mitotic" EXACT []
synonym: "positive regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of transcription from RNA polymerase II promoter, mitotic" NARROW []
synonym: "up regulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
synonym: "up-regulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
synonym: "upregulation of transcription from RNA polymerase II promoter, mitotic" EXACT []
is_a: GO:0045897 ! positive regulation of transcription, mitotic
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0046021 ! regulation of transcription from RNA polymerase II promoter, mitotic

[Term]
id: GO:0046023
name: regulation of transcription from RNA polymerase III promoter, mitotic
namespace: biological_process
def: "A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators]
synonym: "mitotic regulation of transcription from Pol III promoter" EXACT []
synonym: "regulation of transcription from Pol III promoter, mitotic" EXACT []
synonym: "regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006359 ! regulation of transcription from RNA polymerase III promoter
is_a: GO:0045896 ! regulation of transcription, mitotic

[Term]
id: GO:0046024
name: positive regulation of transcription from RNA polymerase III promoter, mitotic
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators]
synonym: "activation of transcription from RNA polymerase III promoter, mitotic" NARROW []
synonym: "mitotic activation of transcription from Pol III promoter" EXACT []
synonym: "positive regulation of transcription from Pol III promoter, mitotic" EXACT []
synonym: "positive regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of transcription from RNA polymerase III promoter, mitotic" NARROW []
synonym: "up regulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
synonym: "up-regulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
synonym: "upregulation of transcription from RNA polymerase III promoter, mitotic" EXACT []
is_a: GO:0045897 ! positive regulation of transcription, mitotic
is_a: GO:0045945 ! positive regulation of transcription from RNA polymerase III promoter
is_a: GO:0046023 ! regulation of transcription from RNA polymerase III promoter, mitotic

[Term]
id: GO:0046025
name: precorrin-6Y C5,15-methyltransferase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2." [EC:2.1.1.132]
subset: gosubset_prok
synonym: "precorrin-6 methyltransferase activity" BROAD [EC:2.1.1.132]
synonym: "precorrin-6Y methylase activity" BROAD [EC:2.1.1.132]
synonym: "S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating)" EXACT [EC:2.1.1.132]
xref: EC:2.1.1.132
xref: MetaCyc:2.1.1.132-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0046026
name: precorrin-4 C11-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5." [EC:2.1.1.133]
subset: gosubset_prok
synonym: "CobM" RELATED [EC:2.1.1.133]
synonym: "S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase activity" EXACT [EC:2.1.1.133]
xref: EC:2.1.1.133
xref: MetaCyc:2.1.1.133-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0046027
name: phospholipid:diacylglycerol acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol." [EC:2.3.1.158]
synonym: "PDAT activity" EXACT [EC:2.3.1.158]
synonym: "phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.158]
xref: EC:2.3.1.158
xref: MetaCyc:2.3.1.158-RXN
xref: Reactome:22783 "phospholipid:diacylglycerol acyltransferase activity"
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0046028
name: electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity
namespace: molecular_function
def: "Enables the directed movement of electrons from the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363]
synonym: "plastocyanin" NARROW []
is_a: GO:0009055 ! electron carrier activity

[Term]
id: GO:0046029
name: mannitol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol + NAD+ = D-mannose + NADH + H+." [EC:1.1.1.255]
synonym: "mannitol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.255]
synonym: "MTD activity" EXACT [EC:1.1.1.255]
synonym: "NAD-dependent mannitol dehydrogenase activity" BROAD [EC:1.1.1.255]
xref: EC:1.1.1.255
xref: MetaCyc:1.1.1.255-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
is_a: GO:0031320 ! hexitol dehydrogenase activity

[Term]
id: GO:0046030
name: inositol trisphosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the removal of one of the three phosphate groups of an inositol trisphosphate." [GOC:bf]
synonym: "inositol-1,4,5-trisphosphate phosphatase" NARROW []
synonym: "IP(3) phosphatase activity" EXACT []
synonym: "IP3 phosphatase activity" EXACT []
is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity

[Term]
id: GO:0046031
name: ADP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "ADP metabolism" EXACT []
is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process

[Term]
id: GO:0046032
name: ADP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "ADP breakdown" EXACT []
synonym: "ADP catabolism" EXACT []
synonym: "ADP degradation" EXACT []
is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process
is_a: GO:0046031 ! ADP metabolic process

[Term]
id: GO:0046033
name: AMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving AMP, adenosine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "adenylate forming enzyme activity" RELATED []
synonym: "AMP metabolism" EXACT []
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0046034
name: ATP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators]
subset: gosubset_prok
synonym: "ATP metabolism" EXACT []
is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0046035
name: CMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CMP, cytidine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "CMP metabolism" EXACT []
is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046036
name: CTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CTP, cytidine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "CTP metabolism" EXACT []
is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046037
name: GMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GMP, guanosine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "GMP metabolism" EXACT []
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0046038
name: GMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "GMP breakdown" EXACT []
synonym: "GMP catabolism" EXACT []
synonym: "GMP degradation" EXACT []
is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process
is_a: GO:0046037 ! GMP metabolic process

[Term]
id: GO:0046039
name: GTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GTP, guanosine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "GTP metabolism" EXACT []
is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0046040
name: IMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving IMP, inosine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "IMP metabolism" EXACT []
is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0046041
name: ITP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ITP, inosine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "ITP metabolism" EXACT []
is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0046042
name: ITP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ITP, inosine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "ITP anabolism" EXACT []
synonym: "ITP biosynthesis" EXACT []
synonym: "ITP formation" EXACT []
synonym: "ITP synthesis" EXACT []
is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process
is_a: GO:0046041 ! ITP metabolic process

[Term]
id: GO:0046043
name: TDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving TDP, ribosylthymine diphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "TDP metabolism" EXACT []
is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process

[Term]
id: GO:0046044
name: TMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving TMP, ribosylthymine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "TMP metabolism" EXACT []
is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process

[Term]
id: GO:0046045
name: TMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of TMP, ribosylthymine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "TMP breakdown" EXACT []
synonym: "TMP catabolism" EXACT []
synonym: "TMP degradation" EXACT []
is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process
is_a: GO:0046044 ! TMP metabolic process

[Term]
id: GO:0046046
name: TTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving TTP, ribosylthymine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "TTP metabolism" EXACT []
is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process

[Term]
id: GO:0046047
name: TTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of TTP, ribosylthymine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "TTP breakdown" EXACT []
synonym: "TTP catabolism" EXACT []
synonym: "TTP degradation" EXACT []
synonym: "TTP hydrolysis" EXACT []
is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process
is_a: GO:0046046 ! TTP metabolic process

[Term]
id: GO:0046048
name: UDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP, uridine (5'-)diphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "UDP metabolism" EXACT []
is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046049
name: UMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UMP, uridine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "UMP metabolism" EXACT []
is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046050
name: UMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "UMP breakdown" EXACT []
synonym: "UMP catabolism" EXACT []
synonym: "UMP degradation" EXACT []
is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process
is_a: GO:0046049 ! UMP metabolic process

[Term]
id: GO:0046051
name: UTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "UTP metabolism" EXACT []
is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046052
name: UTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5'-)triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "UTP breakdown" EXACT []
synonym: "UTP catabolism" EXACT []
synonym: "UTP degradation" EXACT []
synonym: "UTP hydrolysis" EXACT []
is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process
is_a: GO:0046051 ! UTP metabolic process

[Term]
id: GO:0046053
name: dAMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dAMP metabolism" EXACT []
is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0046054
name: dGMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dGMP metabolism" EXACT []
is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0046055
name: dGMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dGMP breakdown" EXACT []
synonym: "dGMP catabolism" EXACT []
synonym: "dGMP degradation" EXACT []
is_a: GO:0009172 ! purine deoxyribonucleoside monophosphate catabolic process
is_a: GO:0046054 ! dGMP metabolic process

[Term]
id: GO:0046056
name: dADP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dADP metabolism" EXACT []
is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0046057
name: dADP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dADP breakdown" EXACT []
synonym: "dADP catabolism" EXACT []
synonym: "dADP degradation" EXACT []
is_a: GO:0009184 ! purine deoxyribonucleoside diphosphate catabolic process
is_a: GO:0046056 ! dADP metabolic process

[Term]
id: GO:0046058
name: cAMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "3',5' cAMP metabolic process" EXACT []
synonym: "3',5' cAMP metabolism" EXACT []
synonym: "3',5'-cAMP metabolic process" EXACT []
synonym: "3',5'-cAMP metabolism" EXACT []
synonym: "adenosine 3',5'-cyclophosphate metabolic process" EXACT []
synonym: "adenosine 3',5'-cyclophosphate metabolism" EXACT []
synonym: "cAMP generating peptide activity" RELATED []
synonym: "cAMP metabolism" EXACT []
synonym: "cyclic AMP metabolic process" EXACT []
synonym: "cyclic AMP metabolism" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0046059
name: dAMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dAMP breakdown" EXACT []
synonym: "dAMP catabolism" EXACT []
synonym: "dAMP degradation" EXACT []
is_a: GO:0009172 ! purine deoxyribonucleoside monophosphate catabolic process
is_a: GO:0046053 ! dAMP metabolic process

[Term]
id: GO:0046060
name: dATP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dATP metabolism" EXACT []
is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0046061
name: dATP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dATP breakdown" EXACT []
synonym: "dATP catabolism" EXACT []
synonym: "dATP degradation" EXACT []
is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0046060 ! dATP metabolic process

[Term]
id: GO:0046062
name: dCDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dCDP, deoxycytidine 5'-diphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dCDP metabolism" EXACT []
is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0046063
name: dCMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dCMP, deoxycytidine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dCMP metabolism" EXACT []
is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0046064
name: dCMP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dCMP, deoxycytidine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dCMP anabolism" EXACT []
synonym: "dCMP biosynthesis" EXACT []
synonym: "dCMP formation" EXACT []
synonym: "dCMP synthesis" EXACT []
is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process
is_a: GO:0046063 ! dCMP metabolic process

[Term]
id: GO:0046065
name: dCTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dCTP, deoxycytidine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dCTP metabolism" EXACT []
is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0046066
name: dGDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dGDP metabolism" EXACT []
is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0046067
name: dGDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dGDP breakdown" EXACT []
synonym: "dGDP catabolism" EXACT []
synonym: "dGDP degradation" EXACT []
is_a: GO:0009184 ! purine deoxyribonucleoside diphosphate catabolic process
is_a: GO:0046066 ! dGDP metabolic process

[Term]
id: GO:0046068
name: cGMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "cGMP metabolism" EXACT []
is_a: GO:0006163 ! purine nucleotide metabolic process
is_a: GO:0009187 ! cyclic nucleotide metabolic process

[Term]
id: GO:0046069
name: cGMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "cGMP breakdown" EXACT []
synonym: "cGMP catabolism" EXACT []
synonym: "cGMP degradation" EXACT []
is_a: GO:0006195 ! purine nucleotide catabolic process
is_a: GO:0009214 ! cyclic nucleotide catabolic process
is_a: GO:0046068 ! cGMP metabolic process

[Term]
id: GO:0046070
name: dGTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dGTP, guanosine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dGTP metabolism" EXACT []
is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0046071
name: dGTP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dGTP, guanosine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dGTP anabolism" EXACT []
synonym: "dGTP biosynthesis" EXACT []
synonym: "dGTP formation" EXACT []
synonym: "dGTP synthesis" EXACT []
xref: Reactome:448548 "dGTP formation"
xref: Reactome:469677 "dGTP formation"
xref: Reactome:487390 "dGTP formation"
xref: Reactome:507341 "dGTP formation"
xref: Reactome:517354 "dGTP formation"
xref: Reactome:526232 "dGTP formation"
xref: Reactome:531114 "dGTP formation"
xref: Reactome:536489 "dGTP formation"
xref: Reactome:542194 "dGTP formation"
xref: Reactome:547553 "dGTP formation"
xref: Reactome:552143 "dGTP formation"
xref: Reactome:557736 "dGTP formation"
xref: Reactome:568355 "dGTP formation"
xref: Reactome:581557 "dGTP formation"
xref: Reactome:585771 "dGTP formation"
xref: Reactome:592444 "dGTP formation"
xref: Reactome:595319 "dGTP formation"
xref: Reactome:597286 "dGTP formation"
xref: Reactome:598092 "dGTP formation"
xref: Reactome:599638 "dGTP formation"
xref: Reactome:600575 "dGTP formation"
xref: Reactome:602438 "dGTP formation"
xref: Reactome:74219 "dGTP formation"
is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process
is_a: GO:0046070 ! dGTP metabolic process

[Term]
id: GO:0046072
name: dTDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dTDP, deoxyribosylthymine diphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dTDP metabolism" EXACT []
is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0046073
name: dTMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dTMP metabolism" EXACT []
is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0046074
name: dTMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dTMP, deoxyribosylthymine monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dTMP breakdown" EXACT []
synonym: "dTMP catabolism" EXACT []
synonym: "dTMP degradation" EXACT []
is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process
is_a: GO:0046073 ! dTMP metabolic process

[Term]
id: GO:0046075
name: dTTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dTTP, deoxyribosylthymine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dTTP metabolism" EXACT []
is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0046076
name: dTTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dTTP, deoxyribosylthymine triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dTTP breakdown" EXACT []
synonym: "dTTP catabolism" EXACT []
synonym: "dTTP degradation" EXACT []
is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0046075 ! dTTP metabolic process

[Term]
id: GO:0046077
name: dUDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dUDP, deoxyuridine (5'-)diphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dUDP metabolism" EXACT []
is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process

[Term]
id: GO:0046078
name: dUMP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dUMP, deoxyuridine (5'-)monophosphate (2'-deoxyuridine 5'-phosphate)." [GOC:go_curators]
subset: gosubset_prok
synonym: "dUMP metabolism" EXACT []
is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process

[Term]
id: GO:0046079
name: dUMP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dUMP breakdown" EXACT []
synonym: "dUMP catabolism" EXACT []
synonym: "dUMP degradation" EXACT []
is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process
is_a: GO:0046078 ! dUMP metabolic process

[Term]
id: GO:0046080
name: dUTP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dUTP metabolism" EXACT []
is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process

[Term]
id: GO:0046081
name: dUTP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators]
subset: gosubset_prok
synonym: "dUTP breakdown" EXACT []
synonym: "dUTP catabolism" EXACT []
synonym: "dUTP degradation" EXACT []
is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process
is_a: GO:0046080 ! dUTP metabolic process

[Term]
id: GO:0046082
name: 5-methylcytosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 5-methylcytosine, a methylated base of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "5-methylcytosine anabolism" EXACT []
synonym: "5-methylcytosine biosynthesis" EXACT []
synonym: "5-methylcytosine formation" EXACT []
synonym: "5-methylcytosine synthesis" EXACT []
is_a: GO:0019856 ! pyrimidine base biosynthetic process
is_a: GO:0019857 ! 5-methylcytosine metabolic process

[Term]
id: GO:0046083
name: adenine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators]
subset: gosubset_prok
synonym: "adenine metabolism" EXACT []
is_a: GO:0006144 ! purine base metabolic process

[Term]
id: GO:0046084
name: adenine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators]
subset: gosubset_prok
synonym: "adenine anabolism" EXACT []
synonym: "adenine biosynthesis" EXACT []
synonym: "adenine formation" EXACT []
synonym: "adenine synthesis" EXACT []
is_a: GO:0009113 ! purine base biosynthetic process
is_a: GO:0046083 ! adenine metabolic process

[Term]
id: GO:0046085
name: adenosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators]
subset: gosubset_prok
synonym: "adenosine metabolism" EXACT []
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046086
name: adenosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators]
subset: gosubset_prok
synonym: "adenosine anabolism" EXACT []
synonym: "adenosine biosynthesis" EXACT []
synonym: "adenosine formation" EXACT []
synonym: "adenosine synthesis" EXACT []
is_a: GO:0046085 ! adenosine metabolic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0046087
name: cytidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:go_curators]
subset: gosubset_prok
synonym: "cytidine metabolism" EXACT []
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046088
name: cytidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:go_curators]
subset: gosubset_prok
synonym: "cytidine anabolism" EXACT []
synonym: "cytidine biosynthesis" EXACT []
synonym: "cytidine formation" EXACT []
synonym: "cytidine synthesis" EXACT []
is_a: GO:0046087 ! cytidine metabolic process
is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process

[Term]
id: GO:0046089
name: cytosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:go_curators]
subset: gosubset_prok
synonym: "cytosine anabolism" EXACT []
synonym: "cytosine biosynthesis" EXACT []
synonym: "cytosine formation" EXACT []
synonym: "cytosine synthesis" EXACT []
is_a: GO:0019856 ! pyrimidine base biosynthetic process
is_a: GO:0019858 ! cytosine metabolic process

[Term]
id: GO:0046090
name: deoxyadenosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyadenosine metabolism" EXACT []
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0046091
name: deoxyadenosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyadenosine anabolism" EXACT []
synonym: "deoxyadenosine biosynthesis" EXACT []
synonym: "deoxyadenosine formation" EXACT []
synonym: "deoxyadenosine synthesis" EXACT []
is_a: GO:0046090 ! deoxyadenosine metabolic process
is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0046092
name: deoxycytidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxycytidine metabolism" EXACT []
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process

[Term]
id: GO:0046093
name: deoxycytidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxycytidine anabolism" EXACT []
synonym: "deoxycytidine biosynthesis" EXACT []
synonym: "deoxycytidine formation" EXACT []
synonym: "deoxycytidine synthesis" EXACT []
is_a: GO:0046092 ! deoxycytidine metabolic process
is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0046094
name: deoxyinosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyinosine metabolism" EXACT []
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0046095
name: deoxyinosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyinosine anabolism" EXACT []
synonym: "deoxyinosine biosynthesis" EXACT []
synonym: "deoxyinosine formation" EXACT []
synonym: "deoxyinosine synthesis" EXACT []
is_a: GO:0046094 ! deoxyinosine metabolic process
is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0046096
name: deoxyuridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyuridine metabolism" EXACT []
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process

[Term]
id: GO:0046097
name: deoxyuridine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyuridine anabolism" EXACT []
synonym: "deoxyuridine biosynthesis" EXACT []
synonym: "deoxyuridine formation" EXACT []
synonym: "deoxyuridine synthesis" EXACT []
is_a: GO:0046096 ! deoxyuridine metabolic process
is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0046098
name: guanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators]
subset: gosubset_prok
synonym: "guanine metabolism" EXACT []
is_a: GO:0006144 ! purine base metabolic process

[Term]
id: GO:0046099
name: guanine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators]
subset: gosubset_prok
synonym: "guanine anabolism" EXACT []
synonym: "guanine biosynthesis" EXACT []
synonym: "guanine formation" EXACT []
synonym: "guanine synthesis" EXACT []
xref: Reactome:448546 "Guanine formation"
xref: Reactome:469675 "Guanine formation"
xref: Reactome:487388 "Guanine formation"
xref: Reactome:507339 "Guanine formation"
xref: Reactome:517352 "Guanine formation"
xref: Reactome:526230 "Guanine formation"
xref: Reactome:536487 "Guanine formation"
xref: Reactome:547551 "Guanine formation"
xref: Reactome:552144 "Guanine formation"
xref: Reactome:557734 "Guanine formation"
xref: Reactome:568356 "Guanine formation"
xref: Reactome:581558 "Guanine formation"
xref: Reactome:592445 "Guanine formation"
xref: Reactome:599635 "Guanine formation"
xref: Reactome:602435 "Guanine formation"
xref: Reactome:74252 "Guanine formation"
is_a: GO:0009113 ! purine base biosynthetic process
is_a: GO:0046098 ! guanine metabolic process

[Term]
id: GO:0046100
name: hypoxanthine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]
subset: gosubset_prok
synonym: "hypoxanthine metabolism" EXACT []
is_a: GO:0006144 ! purine base metabolic process

[Term]
id: GO:0046101
name: hypoxanthine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators]
subset: gosubset_prok
synonym: "hypoxanthine anabolism" EXACT []
synonym: "hypoxanthine biosynthesis" EXACT []
synonym: "hypoxanthine formation" EXACT []
synonym: "hypoxanthine synthesis" EXACT []
xref: Reactome:448524 "Hypoxanthine formation"
xref: Reactome:469654 "Hypoxanthine formation"
xref: Reactome:487366 "Hypoxanthine formation"
xref: Reactome:507317 "Hypoxanthine formation"
xref: Reactome:517332 "Hypoxanthine formation"
xref: Reactome:526212 "Hypoxanthine formation"
xref: Reactome:536471 "Hypoxanthine formation"
xref: Reactome:542175 "Hypoxanthine formation"
xref: Reactome:547535 "Hypoxanthine formation"
xref: Reactome:552126 "Hypoxanthine formation"
xref: Reactome:557717 "Hypoxanthine formation"
xref: Reactome:568335 "Hypoxanthine formation"
xref: Reactome:581537 "Hypoxanthine formation"
xref: Reactome:585754 "Hypoxanthine formation"
xref: Reactome:592425 "Hypoxanthine formation"
xref: Reactome:595300 "Hypoxanthine formation"
xref: Reactome:599621 "Hypoxanthine formation"
xref: Reactome:602419 "Hypoxanthine formation"
xref: Reactome:74243 "Hypoxanthine formation"
is_a: GO:0009113 ! purine base biosynthetic process
is_a: GO:0046100 ! hypoxanthine metabolic process

[Term]
id: GO:0046102
name: inosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators]
subset: gosubset_prok
synonym: "inosine metabolism" EXACT []
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046103
name: inosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators]
subset: gosubset_prok
synonym: "inosine anabolism" EXACT []
synonym: "inosine biosynthesis" EXACT []
synonym: "inosine formation" EXACT []
synonym: "inosine synthesis" EXACT []
xref: Reactome:448744 "Inosine formation"
xref: Reactome:469866 "Inosine formation"
xref: Reactome:487563 "Inosine formation"
xref: Reactome:507519 "Inosine formation"
xref: Reactome:517503 "Inosine formation"
xref: Reactome:526372 "Inosine formation"
xref: Reactome:536565 "Inosine formation"
xref: Reactome:542291 "Inosine formation"
xref: Reactome:547632 "Inosine formation"
xref: Reactome:552224 "Inosine formation"
xref: Reactome:557829 "Inosine formation"
xref: Reactome:568431 "Inosine formation"
xref: Reactome:581633 "Inosine formation"
xref: Reactome:585803 "Inosine formation"
xref: Reactome:592545 "Inosine formation"
xref: Reactome:595364 "Inosine formation"
xref: Reactome:599683 "Inosine formation"
xref: Reactome:602497 "Inosine formation"
xref: Reactome:74236 "Inosine formation"
is_a: GO:0046102 ! inosine metabolic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0046104
name: thymidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyribosylthymine metabolic process" EXACT []
synonym: "deoxyribosylthymine metabolism" EXACT []
synonym: "thymidine metabolism" EXACT []
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process

[Term]
id: GO:0046105
name: thymidine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "deoxyribosylthymine biosynthesis" EXACT []
synonym: "deoxyribosylthymine biosynthetic process" EXACT []
synonym: "thymidine anabolism" EXACT []
synonym: "thymidine biosynthesis" EXACT []
synonym: "thymidine formation" EXACT []
synonym: "thymidine synthesis" EXACT []
is_a: GO:0046104 ! thymidine metabolic process
is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process

[Term]
id: GO:0046106
name: thymine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators]
subset: gosubset_prok
synonym: "thymine anabolism" EXACT []
synonym: "thymine biosynthesis" EXACT []
synonym: "thymine formation" EXACT []
synonym: "thymine synthesis" EXACT []
is_a: GO:0019856 ! pyrimidine base biosynthetic process
is_a: GO:0019859 ! thymine metabolic process

[Term]
id: GO:0046107
name: uracil biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators]
subset: gosubset_prok
synonym: "uracil anabolism" EXACT []
synonym: "uracil biosynthesis" EXACT []
synonym: "uracil formation" EXACT []
synonym: "uracil synthesis" EXACT []
is_a: GO:0019856 ! pyrimidine base biosynthetic process
is_a: GO:0019860 ! uracil metabolic process

[Term]
id: GO:0046108
name: uridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "uridine metabolism" EXACT []
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process

[Term]
id: GO:0046109
name: uridine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "uridine anabolism" EXACT []
synonym: "uridine biosynthesis" EXACT []
synonym: "uridine formation" EXACT []
synonym: "uridine synthesis" EXACT []
is_a: GO:0046108 ! uridine metabolic process
is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process

[Term]
id: GO:0046110
name: xanthine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "xanthine metabolism" EXACT []
is_a: GO:0006144 ! purine base metabolic process

[Term]
id: GO:0046111
name: xanthine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators]
subset: gosubset_prok
synonym: "xanthine anabolism" EXACT []
synonym: "xanthine biosynthesis" EXACT []
synonym: "xanthine formation" EXACT []
synonym: "xanthine synthesis" EXACT []
is_a: GO:0009113 ! purine base biosynthetic process
is_a: GO:0046110 ! xanthine metabolic process

[Term]
id: GO:0046112
name: nucleobase biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai]
subset: gosubset_prok
synonym: "nucleobase anabolism" EXACT []
synonym: "nucleobase biosynthesis" EXACT []
synonym: "nucleobase formation" EXACT []
synonym: "nucleobase synthesis" EXACT []
is_a: GO:0009112 ! nucleobase metabolic process
is_a: GO:0034404 ! nucleobase, nucleoside and nucleotide biosynthetic process

[Term]
id: GO:0046113
name: nucleobase catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai]
subset: gosubset_prok
synonym: "nucleobase breakdown" EXACT []
synonym: "nucleobase catabolism" EXACT []
synonym: "nucleobase degradation" EXACT []
is_a: GO:0009112 ! nucleobase metabolic process
is_a: GO:0034656 ! nucleobase, nucleoside and nucleotide catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0046114
name: guanosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of guanine, guanine riboside, a nucleoside with a wide species distribution." [GOC:go_curators]
subset: gosubset_prok
synonym: "guanosine anabolism" EXACT []
synonym: "guanosine biosynthesis" EXACT []
synonym: "guanosine formation" EXACT []
synonym: "guanosine synthesis" EXACT []
is_a: GO:0008617 ! guanosine metabolic process
is_a: GO:0046129 ! purine ribonucleoside biosynthetic process

[Term]
id: GO:0046115
name: guanosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution." [GOC:go_curators]
subset: gosubset_prok
synonym: "guanosine breakdown" EXACT []
synonym: "guanosine catabolism" EXACT []
synonym: "guanosine degradation" EXACT []
is_a: GO:0008617 ! guanosine metabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process

[Term]
id: GO:0046116
name: queuosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "queuosine metabolism" EXACT []
is_a: GO:0008618 ! 7-methylguanosine metabolic process

[Term]
id: GO:0046117
name: queuosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "queuosine breakdown" EXACT []
synonym: "queuosine catabolism" EXACT []
synonym: "queuosine degradation" EXACT []
is_a: GO:0046116 ! queuosine metabolic process
is_a: GO:0046119 ! 7-methylguanosine catabolic process

[Term]
id: GO:0046118
name: 7-methylguanosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "7-methylguanosine anabolism" EXACT []
synonym: "7-methylguanosine biosynthesis" EXACT []
synonym: "7-methylguanosine formation" EXACT []
synonym: "7-methylguanosine synthesis" EXACT []
is_a: GO:0008618 ! 7-methylguanosine metabolic process
is_a: GO:0046114 ! guanosine biosynthetic process

[Term]
id: GO:0046119
name: 7-methylguanosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "7-methylguanosine breakdown" EXACT []
synonym: "7-methylguanosine catabolism" EXACT []
synonym: "7-methylguanosine degradation" EXACT []
is_a: GO:0008618 ! 7-methylguanosine metabolic process
is_a: GO:0046115 ! guanosine catabolic process

[Term]
id: GO:0046120
name: deoxyribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "deoxyribonucleoside anabolism" EXACT []
synonym: "deoxyribonucleoside biosynthesis" EXACT []
synonym: "deoxyribonucleoside formation" EXACT []
synonym: "deoxyribonucleoside synthesis" EXACT []
is_a: GO:0009120 ! deoxyribonucleoside metabolic process
is_a: GO:0009163 ! nucleoside biosynthetic process

[Term]
id: GO:0046121
name: deoxyribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "deoxyribonucleoside breakdown" EXACT []
synonym: "deoxyribonucleoside catabolism" EXACT []
synonym: "deoxyribonucleoside degradation" EXACT []
is_a: GO:0009120 ! deoxyribonucleoside metabolic process
is_a: GO:0009164 ! nucleoside catabolic process

[Term]
id: GO:0046122
name: purine deoxyribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside metabolism" EXACT []
is_a: GO:0009120 ! deoxyribonucleoside metabolic process
is_a: GO:0042278 ! purine nucleoside metabolic process

[Term]
id: GO:0046123
name: purine deoxyribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any purine deoxyribonucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside anabolism" EXACT []
synonym: "purine deoxyribonucleoside biosynthesis" EXACT []
synonym: "purine deoxyribonucleoside formation" EXACT []
synonym: "purine deoxyribonucleoside synthesis" EXACT []
is_a: GO:0042451 ! purine nucleoside biosynthetic process
is_a: GO:0046120 ! deoxyribonucleoside biosynthetic process
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0046124
name: purine deoxyribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "purine deoxyribonucleoside breakdown" EXACT []
synonym: "purine deoxyribonucleoside catabolism" EXACT []
synonym: "purine deoxyribonucleoside degradation" EXACT []
is_a: GO:0006152 ! purine nucleoside catabolic process
is_a: GO:0046121 ! deoxyribonucleoside catabolic process
is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process

[Term]
id: GO:0046125
name: pyrimidine deoxyribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside metabolism" EXACT []
is_a: GO:0006213 ! pyrimidine nucleoside metabolic process
is_a: GO:0009120 ! deoxyribonucleoside metabolic process

[Term]
id: GO:0046126
name: pyrimidine deoxyribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside anabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside biosynthesis" EXACT []
synonym: "pyrimidine deoxyribonucleoside formation" EXACT []
synonym: "pyrimidine deoxyribonucleoside synthesis" EXACT []
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0046120 ! deoxyribonucleoside biosynthetic process
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process
is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process

[Term]
id: GO:0046127
name: pyrimidine deoxyribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine deoxyribonucleoside breakdown" EXACT []
synonym: "pyrimidine deoxyribonucleoside catabolism" EXACT []
synonym: "pyrimidine deoxyribonucleoside degradation" EXACT []
is_a: GO:0046121 ! deoxyribonucleoside catabolic process
is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process
is_a: GO:0046135 ! pyrimidine nucleoside catabolic process

[Term]
id: GO:0046128
name: purine ribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
subset: gosubset_prok
synonym: "purine ribonucleoside metabolism" EXACT []
is_a: GO:0009119 ! ribonucleoside metabolic process
is_a: GO:0042278 ! purine nucleoside metabolic process

[Term]
id: GO:0046129
name: purine ribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
subset: gosubset_prok
synonym: "purine ribonucleoside anabolism" EXACT []
synonym: "purine ribonucleoside biosynthesis" EXACT []
synonym: "purine ribonucleoside formation" EXACT []
synonym: "purine ribonucleoside synthesis" EXACT []
is_a: GO:0042451 ! purine nucleoside biosynthetic process
is_a: GO:0042455 ! ribonucleoside biosynthetic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046130
name: purine ribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
subset: gosubset_prok
synonym: "purine ribonucleoside breakdown" EXACT []
synonym: "purine ribonucleoside catabolism" EXACT []
synonym: "purine ribonucleoside degradation" EXACT []
is_a: GO:0006152 ! purine nucleoside catabolic process
is_a: GO:0042454 ! ribonucleoside catabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046131
name: pyrimidine ribonucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside metabolism" EXACT []
is_a: GO:0006213 ! pyrimidine nucleoside metabolic process
is_a: GO:0009119 ! ribonucleoside metabolic process

[Term]
id: GO:0046132
name: pyrimidine ribonucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside anabolism" EXACT []
synonym: "pyrimidine ribonucleoside biosynthesis" EXACT []
synonym: "pyrimidine ribonucleoside formation" EXACT []
synonym: "pyrimidine ribonucleoside synthesis" EXACT []
is_a: GO:0042455 ! ribonucleoside biosynthetic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process
is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process

[Term]
id: GO:0046133
name: pyrimidine ribonucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine ribonucleoside breakdown" EXACT []
synonym: "pyrimidine ribonucleoside catabolism" EXACT []
synonym: "pyrimidine ribonucleoside degradation" EXACT []
is_a: GO:0042454 ! ribonucleoside catabolic process
is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process
is_a: GO:0046135 ! pyrimidine nucleoside catabolic process

[Term]
id: GO:0046134
name: pyrimidine nucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine nucleoside anabolism" EXACT []
synonym: "pyrimidine nucleoside biosynthesis" EXACT []
synonym: "pyrimidine nucleoside formation" EXACT []
synonym: "pyrimidine nucleoside synthesis" EXACT []
is_a: GO:0006213 ! pyrimidine nucleoside metabolic process
is_a: GO:0009163 ! nucleoside biosynthetic process

[Term]
id: GO:0046135
name: pyrimidine nucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:ai]
subset: gosubset_prok
synonym: "pyrimidine nucleoside breakdown" EXACT []
synonym: "pyrimidine nucleoside catabolism" EXACT []
synonym: "pyrimidine nucleoside degradation" EXACT []
is_a: GO:0006213 ! pyrimidine nucleoside metabolic process
is_a: GO:0009164 ! nucleoside catabolic process

[Term]
id: GO:0046136
name: positive regulation of vitamin metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
subset: gosubset_prok
synonym: "activation of vitamin metabolic process" NARROW []
synonym: "positive regulation of vitamin metabolism" EXACT []
synonym: "stimulation of vitamin metabolic process" NARROW []
synonym: "up regulation of vitamin metabolic process" EXACT []
synonym: "up-regulation of vitamin metabolic process" EXACT []
synonym: "upregulation of vitamin metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0030656 ! regulation of vitamin metabolic process
relationship: positively_regulates GO:0006766 ! vitamin metabolic process

[Term]
id: GO:0046137
name: negative regulation of vitamin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of vitamin metabolic process" EXACT []
synonym: "down-regulation of vitamin metabolic process" EXACT []
synonym: "downregulation of vitamin metabolic process" EXACT []
synonym: "inhibition of vitamin metabolic process" NARROW []
synonym: "negative regulation of vitamin metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0030656 ! regulation of vitamin metabolic process
relationship: negatively_regulates GO:0006766 ! vitamin metabolic process

[Term]
id: GO:0046138
name: coenzyme and prosthetic group biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "coenzyme and prosthetic group anabolism" EXACT []
synonym: "coenzyme and prosthetic group biosynthesis" EXACT []
synonym: "coenzyme and prosthetic group formation" EXACT []
synonym: "coenzyme and prosthetic group synthesis" EXACT []
is_obsolete: true
consider: GO:0009108
consider: GO:0051191

[Term]
id: GO:0046139
name: coenzyme and prosthetic group catabolic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
synonym: "coenzyme and prosthetic group breakdown" EXACT []
synonym: "coenzyme and prosthetic group catabolism" EXACT []
synonym: "coenzyme and prosthetic group degradation" EXACT []
is_obsolete: true
consider: GO:0009109
consider: GO:0051190

[Term]
id: GO:0046140
name: corrin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai]
subset: gosubset_prok
synonym: "corrin anabolism" EXACT []
synonym: "corrin biosynthesis" EXACT []
synonym: "corrin formation" EXACT []
synonym: "corrin synthesis" EXACT []
is_a: GO:0015009 ! corrin metabolic process
is_a: GO:0033014 ! tetrapyrrole biosynthetic process
is_a: GO:0051188 ! cofactor biosynthetic process

[Term]
id: GO:0046141
name: corrin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai]
subset: gosubset_prok
synonym: "corrin breakdown" EXACT []
synonym: "corrin catabolism" EXACT []
synonym: "corrin degradation" EXACT []
is_a: GO:0015009 ! corrin metabolic process
is_a: GO:0033015 ! tetrapyrrole catabolic process
is_a: GO:0051187 ! cofactor catabolic process

[Term]
id: GO:0046142
name: negative regulation of coenzyme and prosthetic group metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
is_obsolete: true
consider: GO:0051198
consider: GO:0051201

[Term]
id: GO:0046143
name: positive regulation of coenzyme and prosthetic group metabolic process
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai]
comment: This term was made obsolete because it was replaced by more specific terms.
is_obsolete: true
consider: GO:0051197
consider: GO:0051200

[Term]
id: GO:0046144
name: D-alanine family amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-alanine and related amino acids." [GOC:ai]
subset: gosubset_prok
synonym: "D-alanine family amino acid metabolism" EXACT []
is_a: GO:0006522 ! alanine metabolic process

[Term]
id: GO:0046145
name: D-alanine family amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-alanine and related amino acids." [GOC:ai]
subset: gosubset_prok
synonym: "D-alanine family amino acid anabolism" EXACT []
synonym: "D-alanine family amino acid biosynthesis" EXACT []
synonym: "D-alanine family amino acid formation" EXACT []
synonym: "D-alanine family amino acid synthesis" EXACT []
is_a: GO:0006523 ! alanine biosynthetic process
is_a: GO:0046144 ! D-alanine family amino acid metabolic process

[Term]
id: GO:0046146
name: tetrahydrobiopterin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "tetrahydrobiopterin metabolism" EXACT []
is_a: GO:0042558 ! pteridine and derivative metabolic process

[Term]
id: GO:0046147
name: tetrahydrobiopterin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "tetrahydrobiopterin breakdown" EXACT []
synonym: "tetrahydrobiopterin catabolism" EXACT []
synonym: "tetrahydrobiopterin degradation" EXACT []
is_a: GO:0042560 ! pteridine and derivative catabolic process
is_a: GO:0046146 ! tetrahydrobiopterin metabolic process

[Term]
id: GO:0046148
name: pigment biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pigment anabolism" EXACT []
synonym: "pigment biosynthesis" EXACT []
synonym: "pigment formation" EXACT []
synonym: "pigment synthesis" EXACT []
is_a: GO:0009058 ! biosynthetic process
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0046149
name: pigment catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "pigment breakdown" EXACT []
synonym: "pigment catabolism" EXACT []
synonym: "pigment degradation" EXACT []
is_a: GO:0009056 ! catabolic process
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0046150
name: melanin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "melanin breakdown" EXACT []
synonym: "melanin catabolism" EXACT []
synonym: "melanin degradation" EXACT []
is_a: GO:0006582 ! melanin metabolic process
is_a: GO:0046149 ! pigment catabolic process

[Term]
id: GO:0046151
name: eye pigment catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]
synonym: "eye pigment breakdown" EXACT []
synonym: "eye pigment catabolism" EXACT []
synonym: "eye pigment degradation" EXACT []
is_a: GO:0042441 ! eye pigment metabolic process
is_a: GO:0046149 ! pigment catabolic process

[Term]
id: GO:0046152
name: ommochrome metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "ommochrome metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0042441 ! eye pigment metabolic process
is_a: GO:0046158 ! ocellus pigment metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0046153
name: ommochrome catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "ommochrome breakdown" EXACT []
synonym: "ommochrome catabolism" EXACT []
synonym: "ommochrome degradation" EXACT []
is_a: GO:0046151 ! eye pigment catabolic process
is_a: GO:0046152 ! ommochrome metabolic process
is_a: GO:0046159 ! ocellus pigment catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0046154
name: rhodopsin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "rhodopsin metabolism" EXACT []
is_a: GO:0042441 ! eye pigment metabolic process
is_a: GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0046155
name: rhodopsin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "rhodopsin breakdown" EXACT []
synonym: "rhodopsin catabolism" EXACT []
synonym: "rhodopsin degradation" EXACT []
is_a: GO:0044257 ! cellular protein catabolic process
is_a: GO:0046151 ! eye pigment catabolic process
is_a: GO:0046154 ! rhodopsin metabolic process

[Term]
id: GO:0046156
name: siroheme metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sirohaem metabolic process" EXACT []
synonym: "sirohaem metabolism" EXACT []
synonym: "siroheme metabolism" EXACT []
is_a: GO:0042168 ! heme metabolic process

[Term]
id: GO:0046157
name: siroheme catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sirohaem catabolic process" EXACT []
synonym: "sirohaem catabolism" EXACT []
synonym: "siroheme breakdown" EXACT []
synonym: "siroheme catabolism" EXACT []
synonym: "siroheme degradation" EXACT []
is_a: GO:0042167 ! heme catabolic process
is_a: GO:0046156 ! siroheme metabolic process

[Term]
id: GO:0046158
name: ocellus pigment metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, http://cancerweb.ncl.ac.uk/]
synonym: "ocellus pigment metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0043474 ! pigment metabolic process during pigmentation
relationship: part_of GO:0033060 ! ocellus pigmentation

[Term]
id: GO:0046159
name: ocellus pigment catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, http://cancerweb.ncl.ac.uk/]
synonym: "ocellus pigment breakdown" EXACT []
synonym: "ocellus pigment catabolism" EXACT []
synonym: "ocellus pigment degradation" EXACT []
is_a: GO:0046149 ! pigment catabolic process
is_a: GO:0046158 ! ocellus pigment metabolic process

[Term]
id: GO:0046160
name: heme a metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heme a, a derivative of heme found in cytochrome aa3." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "haem a metabolic process" EXACT []
synonym: "haem a metabolism" EXACT []
synonym: "heme a metabolism" EXACT []
is_a: GO:0042168 ! heme metabolic process

[Term]
id: GO:0046161
name: heme a catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heme a, a derivative of heme found in cytochrome aa3." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "haem a catabolic process" EXACT []
synonym: "haem a catabolism" EXACT []
synonym: "heme a breakdown" EXACT []
synonym: "heme a catabolism" EXACT []
synonym: "heme a degradation" EXACT []
is_a: GO:0042167 ! heme catabolic process
is_a: GO:0046160 ! heme a metabolic process

[Term]
id: GO:0046162
name: heme c metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heme c, a derivative of heme found in cytochromes c, b4, and f." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "haem c metabolic process" EXACT []
synonym: "haem c metabolism" EXACT []
synonym: "heme c metabolism" EXACT []
is_a: GO:0042168 ! heme metabolic process

[Term]
id: GO:0046163
name: heme c catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heme c, a derivative of heme found in cytochromes c, b4, and f." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "haem c catabolic process" EXACT []
synonym: "haem c catabolism" EXACT []
synonym: "heme c breakdown" EXACT []
synonym: "heme c catabolism" EXACT []
synonym: "heme c degradation" EXACT []
is_a: GO:0042167 ! heme catabolic process
is_a: GO:0046162 ! heme c metabolic process

[Term]
id: GO:0046164
name: alcohol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [ChEBI:30879, GOC:ai]
subset: gosubset_prok
synonym: "alcohol breakdown" EXACT []
synonym: "alcohol catabolism" EXACT []
synonym: "alcohol degradation" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0044282 ! small molecule catabolic process

[Term]
id: GO:0046165
name: alcohol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [ChEBI:30879, GOC:ai]
subset: gosubset_prok
synonym: "alcohol anabolism" EXACT []
synonym: "alcohol biosynthesis" EXACT []
synonym: "alcohol formation" EXACT []
synonym: "alcohol synthesis" EXACT []
is_a: GO:0006066 ! alcohol metabolic process
is_a: GO:0044283 ! small molecule biosynthetic process

[Term]
id: GO:0046166
name: glyceraldehyde-3-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai]
subset: gosubset_prok
synonym: "glyceraldehyde 3-phosphate biosynthesis" EXACT []
synonym: "glyceraldehyde 3-phosphate biosynthetic process" EXACT []
synonym: "glyceraldehyde-3-phosphate anabolism" EXACT []
synonym: "glyceraldehyde-3-phosphate biosynthesis" EXACT []
synonym: "glyceraldehyde-3-phosphate formation" EXACT []
synonym: "glyceraldehyde-3-phosphate synthesis" EXACT []
is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process
is_a: GO:0046184 ! aldehyde biosynthetic process

[Term]
id: GO:0046167
name: glycerol-3-phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]
subset: gosubset_prok
synonym: "glycerol-3-phosphate anabolism" EXACT []
synonym: "glycerol-3-phosphate biosynthesis" EXACT []
synonym: "glycerol-3-phosphate formation" EXACT []
synonym: "glycerol-3-phosphate synthesis" EXACT []
is_a: GO:0006072 ! glycerol-3-phosphate metabolic process
is_a: GO:0006114 ! glycerol biosynthetic process

[Term]
id: GO:0046168
name: glycerol-3-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai]
subset: gosubset_prok
synonym: "glycerol-3-phosphate breakdown" EXACT []
synonym: "glycerol-3-phosphate catabolism" EXACT []
synonym: "glycerol-3-phosphate degradation" EXACT []
is_a: GO:0006072 ! glycerol-3-phosphate metabolic process
is_a: GO:0019563 ! glycerol catabolic process

[Term]
id: GO:0046169
name: methanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:ai]
subset: gosubset_prok
synonym: "methanol anabolism" EXACT []
synonym: "methanol biosynthesis" EXACT []
synonym: "methanol formation" EXACT []
synonym: "methanol synthesis" EXACT []
is_a: GO:0015945 ! methanol metabolic process
is_a: GO:0034309 ! monohydric alcohol biosynthetic process

[Term]
id: GO:0046170
name: methanol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:ai]
subset: gosubset_prok
synonym: "methanol breakdown" EXACT []
synonym: "methanol catabolism" EXACT []
synonym: "methanol degradation" EXACT []
is_a: GO:0015945 ! methanol metabolic process
is_a: GO:0034310 ! monohydric alcohol catabolic process

[Term]
id: GO:0046171
name: octanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:ai]
subset: gosubset_prok
synonym: "octanol anabolism" EXACT []
synonym: "octanol biosynthesis" EXACT []
synonym: "octanol formation" EXACT []
synonym: "octanol synthesis" EXACT []
is_a: GO:0006070 ! octanol metabolic process
is_a: GO:0034309 ! monohydric alcohol biosynthetic process

[Term]
id: GO:0046172
name: octanol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:ai]
subset: gosubset_prok
synonym: "octanol breakdown" EXACT []
synonym: "octanol catabolism" EXACT []
synonym: "octanol degradation" EXACT []
is_a: GO:0006070 ! octanol metabolic process
is_a: GO:0034310 ! monohydric alcohol catabolic process

[Term]
id: GO:0046173
name: polyol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [ChEBI:26191]
subset: gosubset_prok
synonym: "polyhydric alcohol biosynthetic process" EXACT []
synonym: "polyol anabolism" EXACT []
synonym: "polyol biosynthesis" EXACT []
synonym: "polyol formation" EXACT []
synonym: "polyol synthesis" EXACT []
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0046174
name: polyol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [ChEBI:26191]
subset: gosubset_prok
synonym: "polyhydric alcohol catabolic process" EXACT []
synonym: "polyol breakdown" EXACT []
synonym: "polyol catabolism" EXACT []
synonym: "polyol degradation" EXACT []
is_a: GO:0019751 ! polyol metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0046175
name: aldonic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aldonic acid anabolism" EXACT []
synonym: "aldonic acid biosynthesis" EXACT []
synonym: "aldonic acid formation" EXACT []
synonym: "aldonic acid synthesis" EXACT []
is_a: GO:0019520 ! aldonic acid metabolic process
is_a: GO:0034637 ! cellular carbohydrate biosynthetic process

[Term]
id: GO:0046176
name: aldonic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "aldonic acid breakdown" EXACT []
synonym: "aldonic acid catabolism" EXACT []
synonym: "aldonic acid degradation" EXACT []
is_a: GO:0019520 ! aldonic acid metabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0046177
name: D-gluconate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-gluconate breakdown" EXACT []
synonym: "D-gluconate catabolism" EXACT []
synonym: "D-gluconate degradation" EXACT []
xref: MetaCyc:GLUCONSUPER-PWY
is_a: GO:0019521 ! D-gluconate metabolic process
is_a: GO:0046176 ! aldonic acid catabolic process

[Term]
id: GO:0046178
name: D-gluconate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-gluconate anabolism" EXACT []
synonym: "D-gluconate biosynthesis" EXACT []
synonym: "D-gluconate formation" EXACT []
synonym: "D-gluconate synthesis" EXACT []
is_a: GO:0019521 ! D-gluconate metabolic process
is_a: GO:0046175 ! aldonic acid biosynthetic process

[Term]
id: GO:0046179
name: D-dehydro-D-gluconate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-dehydro-D-gluconate, the anion of D-dehydro-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-dehydro-D-gluconate anabolism" EXACT []
synonym: "D-dehydro-D-gluconate biosynthesis" EXACT []
synonym: "D-dehydro-D-gluconate formation" EXACT []
synonym: "D-dehydro-D-gluconate synthesis" EXACT []
is_a: GO:0019525 ! D-dehydro-D-gluconate metabolic process
is_a: GO:0046175 ! aldonic acid biosynthetic process

[Term]
id: GO:0046180
name: ketogluconate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ketogluconate anabolism" EXACT []
synonym: "ketogluconate biosynthesis" EXACT []
synonym: "ketogluconate formation" EXACT []
synonym: "ketogluconate synthesis" EXACT []
is_a: GO:0019522 ! ketogluconate metabolic process
is_a: GO:0046175 ! aldonic acid biosynthetic process

[Term]
id: GO:0046181
name: ketogluconate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ketogluconate breakdown" EXACT []
synonym: "ketogluconate catabolism" EXACT []
synonym: "ketogluconate degradation" EXACT []
is_a: GO:0019522 ! ketogluconate metabolic process
is_a: GO:0046176 ! aldonic acid catabolic process

[Term]
id: GO:0046182
name: L-idonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "L-idonate anabolism" EXACT []
synonym: "L-idonate biosynthesis" EXACT []
synonym: "L-idonate formation" EXACT []
synonym: "L-idonate synthesis" EXACT []
is_a: GO:0019523 ! L-idonate metabolic process
is_a: GO:0046180 ! ketogluconate biosynthetic process

[Term]
id: GO:0046183
name: L-idonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "L-idonate breakdown" EXACT []
synonym: "L-idonate catabolism" EXACT []
synonym: "L-idonate degradation" EXACT []
is_a: GO:0019523 ! L-idonate metabolic process
is_a: GO:0046181 ! ketogluconate catabolic process

[Term]
id: GO:0046184
name: aldehyde biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai]
subset: gosubset_prok
synonym: "aldehyde anabolism" EXACT []
synonym: "aldehyde biosynthesis" EXACT []
synonym: "aldehyde formation" EXACT []
synonym: "aldehyde synthesis" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0046185
name: aldehyde catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai]
subset: gosubset_prok
synonym: "aldehyde breakdown" EXACT []
synonym: "aldehyde catabolism" EXACT []
synonym: "aldehyde degradation" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0046186
name: acetaldehyde biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:ai]
subset: gosubset_prok
synonym: "acetaldehyde anabolism" EXACT []
synonym: "acetaldehyde biosynthesis" EXACT []
synonym: "acetaldehyde formation" EXACT []
synonym: "acetaldehyde synthesis" EXACT []
is_a: GO:0006117 ! acetaldehyde metabolic process
is_a: GO:0046184 ! aldehyde biosynthetic process

[Term]
id: GO:0046187
name: acetaldehyde catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:ai]
subset: gosubset_prok
synonym: "acetaldehyde breakdown" EXACT []
synonym: "acetaldehyde catabolism" EXACT []
synonym: "acetaldehyde degradation" EXACT []
is_a: GO:0006117 ! acetaldehyde metabolic process
is_a: GO:0046185 ! aldehyde catabolic process

[Term]
id: GO:0046188
name: methane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai]
subset: gosubset_prok
synonym: "methane breakdown" EXACT []
synonym: "methane catabolism" EXACT []
synonym: "methane degradation" EXACT []
is_a: GO:0015947 ! methane metabolic process
is_a: GO:0043448 ! alkane catabolic process

[Term]
id: GO:0046189
name: phenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. The largest single use of phenol is in the production of plastics, but it is also used in the synthesis of caprolactam, a precursor for nylon 6 and other man-made fibers." [GOC:ai]
subset: gosubset_prok
synonym: "phenol anabolism" EXACT []
synonym: "phenol biosynthesis" EXACT []
synonym: "phenol formation" EXACT []
synonym: "phenol synthesis" EXACT []
is_a: GO:0018958 ! phenol metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0046190
name: aerobic phenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "aerobic phenol anabolism" EXACT []
synonym: "aerobic phenol biosynthesis" EXACT []
synonym: "aerobic phenol formation" EXACT []
synonym: "aerobic phenol synthesis" EXACT []
is_a: GO:0018959 ! aerobic phenol metabolic process
is_a: GO:0046189 ! phenol biosynthetic process

[Term]
id: GO:0046191
name: aerobic phenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "aerobic phenol breakdown" EXACT []
synonym: "aerobic phenol catabolism" EXACT []
synonym: "aerobic phenol degradation" EXACT []
is_a: GO:0018959 ! aerobic phenol metabolic process
is_a: GO:0019336 ! phenol catabolic process

[Term]
id: GO:0046192
name: anaerobic phenol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic phenol anabolism" EXACT []
synonym: "anaerobic phenol biosynthesis" EXACT []
synonym: "anaerobic phenol formation" EXACT []
synonym: "anaerobic phenol synthesis" EXACT []
is_a: GO:0042215 ! anaerobic phenol metabolic process
is_a: GO:0046189 ! phenol biosynthetic process

[Term]
id: GO:0046193
name: anaerobic phenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic phenol breakdown" EXACT []
synonym: "anaerobic phenol catabolism" EXACT []
synonym: "anaerobic phenol degradation" EXACT []
is_a: GO:0019336 ! phenol catabolic process
is_a: GO:0042215 ! anaerobic phenol metabolic process

[Term]
id: GO:0046194
name: pentachlorophenol biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [GOC:ai]
comment: This term was made obsolete because pentachlorophenol is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "pentachlorophenol anabolism" EXACT []
synonym: "pentachlorophenol biosynthesis" EXACT []
synonym: "pentachlorophenol formation" EXACT []
synonym: "pentachlorophenol synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018961

[Term]
id: GO:0046195
name: 4-nitrophenol biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:ai]
comment: This term was made obsolete because 4-nitrophenol is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "4-nitrophenol anabolism" EXACT []
synonym: "4-nitrophenol biosynthesis" EXACT []
synonym: "4-nitrophenol formation" EXACT []
synonym: "4-nitrophenol synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018960

[Term]
id: GO:0046196
name: 4-nitrophenol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:ai]
subset: gosubset_prok
synonym: "4-nitrophenol breakdown" EXACT []
synonym: "4-nitrophenol catabolism" EXACT []
synonym: "4-nitrophenol degradation" EXACT []
is_a: GO:0018960 ! 4-nitrophenol metabolic process
is_a: GO:0019336 ! phenol catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0046197
name: orcinol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants." [GOC:ai]
subset: gosubset_prok
synonym: "orcinol anabolism" EXACT []
synonym: "orcinol biosynthesis" EXACT []
synonym: "orcinol formation" EXACT []
synonym: "orcinol synthesis" EXACT []
is_a: GO:0018940 ! orcinol metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0034312 ! diol biosynthetic process

[Term]
id: GO:0046198
name: cresol biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [GOC:ai]
comment: This term was made obsolete because cresol is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "cresol anabolism" EXACT []
synonym: "cresol biosynthesis" EXACT []
synonym: "cresol formation" EXACT []
synonym: "cresol synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0042212

[Term]
id: GO:0046199
name: cresol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [GOC:ai]
subset: gosubset_prok
synonym: "cresol breakdown" EXACT []
synonym: "cresol catabolism" EXACT []
synonym: "cresol degradation" EXACT []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042212 ! cresol metabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0046200
name: m-cresol biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of m-cresol (3-hydroxytoluene), the meta-isoform of cresol." [GOC:ai]
comment: This term was made obsolete because m-cresol is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "m-cresol anabolism" EXACT []
synonym: "m-cresol biosynthesis" EXACT []
synonym: "m-cresol formation" EXACT []
synonym: "m-cresol synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018925

[Term]
id: GO:0046201
name: cyanate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyanate, NCO-, the anion of cyanic acid." [GOC:ai]
subset: gosubset_prok
synonym: "cyanate anabolism" EXACT []
synonym: "cyanate biosynthesis" EXACT []
synonym: "cyanate formation" EXACT []
synonym: "cyanate synthesis" EXACT []
is_a: GO:0009439 ! cyanate metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process

[Term]
id: GO:0046202
name: cyanide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration." [GOC:ai]
subset: gosubset_prok
synonym: "cyanide anabolism" EXACT []
synonym: "cyanide biosynthesis" EXACT []
synonym: "cyanide formation" EXACT []
synonym: "cyanide synthesis" EXACT []
is_a: GO:0019499 ! cyanide metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process

[Term]
id: GO:0046203
name: spermidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai]
subset: gosubset_prok
synonym: "spermidine breakdown" EXACT []
synonym: "spermidine catabolism" EXACT []
synonym: "spermidine degradation" EXACT []
is_a: GO:0006598 ! polyamine catabolic process
is_a: GO:0008216 ! spermidine metabolic process

[Term]
id: GO:0046204
name: nor-spermidine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai]
subset: gosubset_prok
synonym: "nor-spermidine metabolism" EXACT []
is_a: GO:0008216 ! spermidine metabolic process

[Term]
id: GO:0046205
name: nor-spermidine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai]
subset: gosubset_prok
synonym: "nor-spermidine breakdown" EXACT []
synonym: "nor-spermidine catabolism" EXACT []
synonym: "nor-spermidine degradation" EXACT []
is_a: GO:0046203 ! spermidine catabolic process
is_a: GO:0046204 ! nor-spermidine metabolic process

[Term]
id: GO:0046206
name: trypanothione metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress." [GOC:ai]
subset: gosubset_prok
synonym: "trypanothione metabolism" EXACT []
is_a: GO:0008216 ! spermidine metabolic process

[Term]
id: GO:0046207
name: trypanothione catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress." [GOC:ai]
subset: gosubset_prok
synonym: "trypanothione breakdown" EXACT []
synonym: "trypanothione catabolism" EXACT []
synonym: "trypanothione degradation" EXACT []
is_a: GO:0046203 ! spermidine catabolic process
is_a: GO:0046206 ! trypanothione metabolic process

[Term]
id: GO:0046208
name: spermine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "spermine breakdown" EXACT []
synonym: "spermine catabolism" EXACT []
synonym: "spermine degradation" EXACT []
is_a: GO:0006598 ! polyamine catabolic process
is_a: GO:0008215 ! spermine metabolic process

[Term]
id: GO:0046209
name: nitric oxide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai]
subset: gosubset_prok
synonym: "nitric oxide metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0046210
name: nitric oxide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai]
subset: gosubset_prok
synonym: "nitric oxide breakdown" EXACT []
synonym: "nitric oxide catabolism" EXACT []
synonym: "nitric oxide degradation" EXACT []
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046209 ! nitric oxide metabolic process

[Term]
id: GO:0046211
name: (+)-camphor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of (+)-camphor, a bicyclic monoterpene ketone." [GOC:ai]
subset: gosubset_prok
synonym: "(+)-camphor anabolism" EXACT []
synonym: "(+)-camphor biosynthesis" EXACT []
synonym: "(+)-camphor formation" EXACT []
synonym: "(+)-camphor synthesis" EXACT []
is_a: GO:0018882 ! (+)-camphor metabolic process
is_a: GO:0042181 ! ketone biosynthetic process
is_a: GO:0043693 ! monoterpene biosynthetic process

[Term]
id: GO:0046212
name: methyl ethyl ketone biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints." [GOC:ai]
comment: This term was made obsolete because methyl ethyl ketone is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "methyl ethyl ketone anabolism" EXACT []
synonym: "methyl ethyl ketone biosynthesis" EXACT []
synonym: "methyl ethyl ketone formation" EXACT []
synonym: "methyl ethyl ketone synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018928

[Term]
id: GO:0046213
name: methyl ethyl ketone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor." [GOC:ai]
subset: gosubset_prok
synonym: "methyl ethyl ketone breakdown" EXACT []
synonym: "methyl ethyl ketone catabolism" EXACT []
synonym: "methyl ethyl ketone degradation" EXACT []
is_a: GO:0018928 ! methyl ethyl ketone metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042182 ! ketone catabolic process

[Term]
id: GO:0046214
name: enterobactin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [GOC:ai]
subset: gosubset_prok
synonym: "enterobactin breakdown" EXACT []
synonym: "enterobactin catabolism" EXACT []
synonym: "enterobactin degradation" EXACT []
is_a: GO:0009238 ! enterobactin metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0046215 ! siderophore catabolic process

[Term]
id: GO:0046215
name: siderophore catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [GOC:ai]
subset: gosubset_prok
synonym: "siderochrome catabolism" NARROW []
synonym: "siderophore breakdown" EXACT []
synonym: "siderophore catabolism" EXACT []
synonym: "siderophore degradation" EXACT []
is_a: GO:0009237 ! siderophore metabolic process
is_a: GO:0051187 ! cofactor catabolic process

[Term]
id: GO:0046216
name: indole phytoalexin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:ai]
subset: gosubset_prok
synonym: "indole phytoalexin breakdown" EXACT []
synonym: "indole phytoalexin catabolism" EXACT []
synonym: "indole phytoalexin degradation" EXACT []
is_a: GO:0042436 ! indole derivative catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046217 ! indole phytoalexin metabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0052316 ! phytoalexin catabolic process

[Term]
id: GO:0046217
name: indole phytoalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:ai]
subset: gosubset_prok
synonym: "indole phytoalexin metabolism" EXACT []
is_a: GO:0019748 ! secondary metabolic process
is_a: GO:0042431 ! indole metabolic process
is_a: GO:0042434 ! indole derivative metabolic process
is_a: GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0046218
name: indolalkylamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "indolalkylamine breakdown" EXACT []
synonym: "indolalkylamine catabolism" EXACT []
synonym: "indolalkylamine degradation" EXACT []
is_a: GO:0006586 ! indolalkylamine metabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
is_a: GO:0042436 ! indole derivative catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0046219
name: indolalkylamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "indolalkylamine anabolism" EXACT []
synonym: "indolalkylamine biosynthesis" EXACT []
synonym: "indolalkylamine formation" EXACT []
synonym: "indolalkylamine synthesis" EXACT []
is_a: GO:0006586 ! indolalkylamine metabolic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process
is_a: GO:0042435 ! indole derivative biosynthetic process

[Term]
id: GO:0046220
name: pyridine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [GOC:ai]
subset: gosubset_prok
synonym: "pyridine anabolism" EXACT []
synonym: "pyridine biosynthesis" EXACT []
synonym: "pyridine formation" EXACT []
synonym: "pyridine synthesis" EXACT []
is_a: GO:0019438 ! aromatic compound biosynthetic process
is_a: GO:0019507 ! pyridine metabolic process

[Term]
id: GO:0046221
name: pyridine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [GOC:ai]
subset: gosubset_prok
synonym: "pyridine breakdown" EXACT []
synonym: "pyridine catabolism" EXACT []
synonym: "pyridine degradation" EXACT []
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0019507 ! pyridine metabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0046222
name: aflatoxin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [GOC:ai]
subset: gosubset_prok
synonym: "aflatoxin metabolism" EXACT []
is_a: GO:0009804 ! coumarin metabolic process
is_a: GO:0043385 ! mycotoxin metabolic process

[Term]
id: GO:0046223
name: aflatoxin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [GOC:ai]
subset: gosubset_prok
synonym: "aflatoxin breakdown" EXACT []
synonym: "aflatoxin catabolism" EXACT []
synonym: "aflatoxin degradation" EXACT []
is_a: GO:0043387 ! mycotoxin catabolic process
is_a: GO:0046222 ! aflatoxin metabolic process
is_a: GO:0046226 ! coumarin catabolic process

[Term]
id: GO:0046224
name: bacteriocin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving bacteriocins, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:ai]
subset: gosubset_prok
synonym: "bacteriocin metabolism" EXACT []
is_a: GO:0009404 ! toxin metabolic process
is_a: GO:0030650 ! peptide antibiotic metabolic process

[Term]
id: GO:0046225
name: bacteriocin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:ai]
subset: gosubset_prok
synonym: "bacteriocin breakdown" EXACT []
synonym: "bacteriocin catabolism" EXACT []
synonym: "bacteriocin degradation" EXACT []
is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0017001 ! antibiotic catabolic process
is_a: GO:0046224 ! bacteriocin metabolic process

[Term]
id: GO:0046226
name: coumarin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:ai]
subset: gosubset_prok
synonym: "coumarin breakdown" EXACT []
synonym: "coumarin catabolism" EXACT []
synonym: "coumarin degradation" EXACT []
is_a: GO:0009804 ! coumarin metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0046227
name: 2,4,5-trichlorophenoxyacetic acid biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide." [GOC:ai]
comment: This term was made obsolete because 2,4,5-trichlorophenoxyacetic acid is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "2,4,5-trichlorophenoxyacetic acid anabolism" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid biosynthesis" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid formation" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018980

[Term]
id: GO:0046228
name: 2,4,5-trichlorophenoxyacetic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide." [GOC:ai]
subset: gosubset_prok
synonym: "2,4,5-trichlorophenoxyacetic acid breakdown" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid catabolism" EXACT []
synonym: "2,4,5-trichlorophenoxyacetic acid degradation" EXACT []
is_a: GO:0018980 ! 2,4,5-trichlorophenoxyacetic acid metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0046229
name: 2-aminobenzenesulfonate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [GOC:ai]
comment: This term was made obsolete because 2-aminobenzenesulfonate is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "2-aminobenzenesulfonate anabolism" EXACT []
synonym: "2-aminobenzenesulfonate biosynthesis" EXACT []
synonym: "2-aminobenzenesulfonate formation" EXACT []
synonym: "2-aminobenzenesulfonate synthesis" EXACT []
synonym: "2-aminobenzenesulphonate biosynthesis" EXACT []
synonym: "2-aminobenzenesulphonate biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0018868

[Term]
id: GO:0046230
name: 2-aminobenzenesulfonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [GOC:ai]
subset: gosubset_prok
synonym: "2-aminobenzenesulfonate breakdown" EXACT []
synonym: "2-aminobenzenesulfonate catabolism" EXACT []
synonym: "2-aminobenzenesulfonate degradation" EXACT []
synonym: "2-aminobenzenesulphonate catabolic process" EXACT []
synonym: "2-aminobenzenesulphonate catabolism" EXACT []
is_a: GO:0018868 ! 2-aminobenzenesulfonate metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0046231
name: carbazole biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:ai]
comment: This term was made obsolete because carbazole is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "carbazole anabolism" EXACT []
synonym: "carbazole biosynthesis" EXACT []
synonym: "carbazole formation" EXACT []
synonym: "carbazole synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018884

[Term]
id: GO:0046232
name: carbazole catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:ai]
subset: gosubset_prok
synonym: "carbazole breakdown" EXACT []
synonym: "carbazole catabolism" EXACT []
synonym: "carbazole degradation" EXACT []
is_a: GO:0018884 ! carbazole metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0046233
name: 3-hydroxyphenylacetate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/]
comment: This term was made obsolete because 3-hydroxyphenylacetate is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "3-hydroxyphenylacetate anabolism" EXACT []
synonym: "3-hydroxyphenylacetate biosynthesis" EXACT []
synonym: "3-hydroxyphenylacetate formation" EXACT []
synonym: "3-hydroxyphenylacetate synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0019609

[Term]
id: GO:0046234
name: fluorene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [GOC:ai]
comment: This term was made obsolete because fluorene is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "fluorene anabolism" EXACT []
synonym: "fluorene biosynthesis" EXACT []
synonym: "fluorene formation" EXACT []
synonym: "fluorene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018917

[Term]
id: GO:0046235
name: gallate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid)." [GOC:ai]
subset: gosubset_prok
synonym: "gallate anabolism" EXACT []
synonym: "gallate biosynthesis" EXACT []
synonym: "gallate formation" EXACT []
synonym: "gallate synthesis" EXACT []
synonym: "gallic acid biosynthesis" EXACT []
synonym: "gallic acid biosynthetic process" EXACT []
is_a: GO:0009713 ! catechol biosynthetic process
is_a: GO:0018918 ! gallate metabolic process

[Term]
id: GO:0046236
name: mandelate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:ai]
subset: gosubset_prok
synonym: "mandelate anabolism" EXACT []
synonym: "mandelate biosynthesis" EXACT []
synonym: "mandelate formation" EXACT []
synonym: "mandelate synthesis" EXACT []
is_a: GO:0018924 ! mandelate metabolic process
is_a: GO:0019438 ! aromatic compound biosynthetic process

[Term]
id: GO:0046237
name: phenanthrene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of phenanthrene, a tricyclic aromatic hydrocarbon." [GOC:ai]
comment: This term was made obsolete because phenanthrene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "phenanthrene anabolism" EXACT []
synonym: "phenanthrene biosynthesis" EXACT []
synonym: "phenanthrene formation" EXACT []
synonym: "phenanthrene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018955

[Term]
id: GO:0046238
name: phthalate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of phthalate, any ester or salt of phthalic acid." [GOC:ai]
comment: This term was made obsolete because phthalates are not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "phthalate anabolism" EXACT []
synonym: "phthalate biosynthesis" EXACT []
synonym: "phthalate formation" EXACT []
synonym: "phthalate synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018963

[Term]
id: GO:0046239
name: phthalate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phthalate, the anion of phthalic acid." [GOC:ai]
subset: gosubset_prok
synonym: "phthalate breakdown" EXACT []
synonym: "phthalate catabolism" EXACT []
synonym: "phthalate degradation" EXACT []
is_a: GO:0018963 ! phthalate metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043649 ! dicarboxylic acid catabolic process

[Term]
id: GO:0046240
name: xylene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:ai]
comment: This term was made obsolete because xylene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "xylene anabolism" EXACT []
synonym: "xylene biosynthesis" EXACT []
synonym: "xylene formation" EXACT []
synonym: "xylene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018948

[Term]
id: GO:0046241
name: m-xylene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon." [GOC:ai]
comment: This term was made obsolete because m-xylene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "m-xylene anabolism" EXACT []
synonym: "m-xylene biosynthesis" EXACT []
synonym: "m-xylene formation" EXACT []
synonym: "m-xylene synthesis" EXACT []
synonym: "meta-xylene biosynthesis" EXACT []
synonym: "meta-xylene biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0018949

[Term]
id: GO:0046242
name: o-xylene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:ai]
comment: This term was made obsolete because o-xylene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "o-xylene anabolism" EXACT []
synonym: "o-xylene biosynthesis" EXACT []
synonym: "o-xylene formation" EXACT []
synonym: "o-xylene synthesis" EXACT []
synonym: "ortho-xylene biosynthesis" EXACT []
synonym: "ortho-xylene biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0018950

[Term]
id: GO:0046243
name: p-xylene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon." [GOC:ai]
comment: This term was made obsolete because p-xylene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "p-xylene anabolism" EXACT []
synonym: "p-xylene biosynthesis" EXACT []
synonym: "p-xylene formation" EXACT []
synonym: "p-xylene synthesis" EXACT []
synonym: "para-xylene biosynthesis" EXACT []
synonym: "para-xylene biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0018951

[Term]
id: GO:0046244
name: salicylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "salicylic acid breakdown" EXACT []
synonym: "salicylic acid catabolism" EXACT []
synonym: "salicylic acid degradation" EXACT []
is_a: GO:0009696 ! salicylic acid metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0046245
name: styrene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GOC:ai]
comment: This term was made obsolete because styrene is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "styrene anabolism" EXACT []
synonym: "styrene biosynthesis" EXACT []
synonym: "styrene formation" EXACT []
synonym: "styrene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018966

[Term]
id: GO:0046246
name: terpene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terpenes, any of a large group of hydrocarbons made up of isoprene units." [GOC:ai]
subset: gosubset_prok
synonym: "terpene anabolism" EXACT []
synonym: "terpene biosynthesis" EXACT []
synonym: "terpene formation" EXACT []
synonym: "terpene synthesis" EXACT []
is_a: GO:0008299 ! isoprenoid biosynthetic process
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:0046247
name: terpene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units." [GOC:ai]
subset: gosubset_prok
synonym: "terpene breakdown" EXACT []
synonym: "terpene catabolism" EXACT []
synonym: "terpene degradation" EXACT []
is_a: GO:0008300 ! isoprenoid catabolic process
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:0046248
name: alpha-pinene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature." [GOC:ai]
subset: gosubset_prok
synonym: "alpha-pinene anabolism" EXACT []
synonym: "alpha-pinene biosynthesis" EXACT []
synonym: "alpha-pinene formation" EXACT []
synonym: "alpha-pinene synthesis" EXACT []
is_a: GO:0018867 ! alpha-pinene metabolic process
is_a: GO:0043693 ! monoterpene biosynthetic process

[Term]
id: GO:0046249
name: alpha-pinene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature." [GOC:ai]
subset: gosubset_prok
synonym: "alpha-pinene breakdown" EXACT []
synonym: "alpha-pinene catabolism" EXACT []
synonym: "alpha-pinene degradation" EXACT []
is_a: GO:0018867 ! alpha-pinene metabolic process
is_a: GO:0043694 ! monoterpene catabolic process

[Term]
id: GO:0046250
name: limonene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [GOC:ai]
subset: gosubset_prok
synonym: "limonene anabolism" EXACT []
synonym: "limonene biosynthesis" EXACT []
synonym: "limonene formation" EXACT []
synonym: "limonene synthesis" EXACT []
is_a: GO:0018923 ! limonene metabolic process
is_a: GO:0043693 ! monoterpene biosynthetic process

[Term]
id: GO:0046251
name: limonene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [GOC:ai]
subset: gosubset_prok
synonym: "limonene breakdown" EXACT []
synonym: "limonene catabolism" EXACT []
synonym: "limonene degradation" EXACT []
is_a: GO:0018923 ! limonene metabolic process
is_a: GO:0043694 ! monoterpene catabolic process

[Term]
id: GO:0046252
name: toluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [GOC:ai]
comment: This term was made obsolete because toluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "toluene anabolism" EXACT []
synonym: "toluene biosynthesis" EXACT []
synonym: "toluene formation" EXACT []
synonym: "toluene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018970

[Term]
id: GO:0046253
name: anaerobic toluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen." [GOC:ai]
comment: This term was made obsolete because toluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "anaerobic toluene anabolism" EXACT []
synonym: "anaerobic toluene biosynthesis" EXACT []
synonym: "anaerobic toluene formation" EXACT []
synonym: "anaerobic toluene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018971

[Term]
id: GO:0046254
name: anaerobic toluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic toluene breakdown" EXACT []
synonym: "anaerobic toluene catabolism" EXACT []
synonym: "anaerobic toluene degradation" EXACT []
xref: MetaCyc:PWY-81
is_a: GO:0018971 ! anaerobic toluene metabolic process
is_a: GO:0042203 ! toluene catabolic process

[Term]
id: GO:0046255
name: 2,4,6-trinitrotoluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai]
comment: This term was made obsolete because 2,4,6-trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "2,4,6-trinitrotoluene anabolism" EXACT []
synonym: "2,4,6-trinitrotoluene biosynthesis" EXACT []
synonym: "2,4,6-trinitrotoluene formation" EXACT []
synonym: "2,4,6-trinitrotoluene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018974

[Term]
id: GO:0046256
name: 2,4,6-trinitrotoluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid." [GOC:ai]
subset: gosubset_prok
synonym: "2,4,6-trinitrotoluene breakdown" EXACT []
synonym: "2,4,6-trinitrotoluene catabolism" EXACT []
synonym: "2,4,6-trinitrotoluene degradation" EXACT []
is_a: GO:0018974 ! 2,4,6-trinitrotoluene metabolic process
is_a: GO:0046260 ! trinitrotoluene catabolic process

[Term]
id: GO:0046257
name: anaerobic 2,4,6-trinitrotoluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen." [GOC:ai]
comment: This term was made obsolete because 2,4,6-trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "anaerobic 2,4,6-trinitrotoluene anabolism" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene biosynthesis" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene formation" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018975

[Term]
id: GO:0046258
name: anaerobic 2,4,6-trinitrotoluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen." [GOC:ai]
subset: gosubset_prok
synonym: "anaerobic 2,4,6-trinitrotoluene breakdown" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene catabolism" EXACT []
synonym: "anaerobic 2,4,6-trinitrotoluene degradation" EXACT []
is_a: GO:0018975 ! anaerobic 2,4,6-trinitrotoluene metabolic process
is_a: GO:0046254 ! anaerobic toluene catabolic process
is_a: GO:0046256 ! 2,4,6-trinitrotoluene catabolic process

[Term]
id: GO:0046259
name: trinitrotoluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it." [GOC:ai]
comment: This term was made obsolete because trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "trinitrotoluene anabolism" EXACT []
synonym: "trinitrotoluene biosynthesis" EXACT []
synonym: "trinitrotoluene formation" EXACT []
synonym: "trinitrotoluene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018973

[Term]
id: GO:0046260
name: trinitrotoluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of trinitrotoluene, a methylated benzene entity with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai]
subset: gosubset_prok
synonym: "trinitrotoluene breakdown" EXACT []
synonym: "trinitrotoluene catabolism" EXACT []
synonym: "trinitrotoluene degradation" EXACT []
is_a: GO:0018973 ! trinitrotoluene metabolic process
is_a: GO:0046263 ! nitrotoluene catabolic process

[Term]
id: GO:0046261
name: 4-nitrotoluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-nitrotoluene, 1-methyl-4-nitrobenzene." [GOC:ai]
comment: This term was made obsolete because 4-nitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "4-nitrotoluene anabolism" EXACT []
synonym: "4-nitrotoluene biosynthesis" EXACT []
synonym: "4-nitrotoluene formation" EXACT []
synonym: "4-nitrotoluene synthesis" EXACT []
synonym: "4NT biosynthesis" EXACT []
synonym: "4NT biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0019257

[Term]
id: GO:0046262
name: nitrotoluene biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai]
comment: This term was made obsolete because nitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "nitrotoluene anabolism" EXACT []
synonym: "nitrotoluene biosynthesis" EXACT []
synonym: "nitrotoluene formation" EXACT []
synonym: "nitrotoluene synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0019326

[Term]
id: GO:0046263
name: nitrotoluene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai]
subset: gosubset_prok
synonym: "nitrotoluene breakdown" EXACT []
synonym: "nitrotoluene catabolism" EXACT []
synonym: "nitrotoluene degradation" EXACT []
is_a: GO:0019326 ! nitrotoluene metabolic process
is_a: GO:0042203 ! toluene catabolic process

[Term]
id: GO:0046264
name: thiocyanate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of thiocyanate, any anion or salt of thiocyanic acid." [GOC:ai]
comment: This term was made obsolete because thiocyanates are not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "thiocyanate anabolism" EXACT []
synonym: "thiocyanate biosynthesis" EXACT []
synonym: "thiocyanate formation" EXACT []
synonym: "thiocyanate synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018969

[Term]
id: GO:0046265
name: thiocyanate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of thiocyanate, any anion of thiocyanic acid." [GOC:ai]
subset: gosubset_prok
synonym: "thiocyanate breakdown" EXACT []
synonym: "thiocyanate catabolism" EXACT []
synonym: "thiocyanate degradation" EXACT []
is_a: GO:0018969 ! thiocyanate metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0044282 ! small molecule catabolic process

[Term]
id: GO:0046266
name: triethanolamine biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:ai]
comment: This term was made obsolete because triethanolamine is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "triethanolamine anabolism" EXACT []
synonym: "triethanolamine biosynthesis" EXACT []
synonym: "triethanolamine formation" EXACT []
synonym: "triethanolamine synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018981

[Term]
id: GO:0046267
name: triethanolamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:ai]
subset: gosubset_prok
synonym: "triethanolamine breakdown" EXACT []
synonym: "triethanolamine catabolism" EXACT []
synonym: "triethanolamine degradation" EXACT []
is_a: GO:0018981 ! triethanolamine metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0046268
name: toluene-4-sulfonate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule." [GOC:ai]
comment: This term was made obsolete because toluene-4-sulfonate is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "4-toluenesulfonate biosynthesis" EXACT []
synonym: "4-toluenesulfonate biosynthetic process" EXACT []
synonym: "toluene-4-sulfonate anabolism" EXACT []
synonym: "toluene-4-sulfonate biosynthesis" EXACT []
synonym: "toluene-4-sulfonate formation" EXACT []
synonym: "toluene-4-sulfonate synthesis" EXACT []
synonym: "toluene-4-sulphonate biosynthesis" EXACT []
synonym: "toluene-4-sulphonate biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0018972

[Term]
id: GO:0046269
name: toluene-4-sulfonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule." [GOC:ai]
subset: gosubset_prok
synonym: "4-toluenesulfonate catabolic process" EXACT []
synonym: "4-toluenesulfonate catabolism" EXACT []
synonym: "toluene-4-sulfonate breakdown" EXACT []
synonym: "toluene-4-sulfonate catabolism" EXACT []
synonym: "toluene-4-sulfonate degradation" EXACT []
synonym: "toluene-4-sulphonate catabolic process" EXACT []
synonym: "toluene-4-sulphonate catabolism" EXACT []
is_a: GO:0018972 ! toluene-4-sulfonate metabolic process
is_a: GO:0042203 ! toluene catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0044282 ! small molecule catabolic process

[Term]
id: GO:0046270
name: 4-toluenecarboxylate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai]
comment: This term was made obsolete because 4-toluenecarboxylate is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "4-toluenecarboxylate anabolism" EXACT []
synonym: "4-toluenecarboxylate biosynthesis" EXACT []
synonym: "4-toluenecarboxylate formation" EXACT []
synonym: "4-toluenecarboxylate synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0019611

[Term]
id: GO:0046271
name: phenylpropanoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of aromatic derivatives of trans-cinnamic acid." [GOC:ai]
subset: gosubset_prok
synonym: "phenylpropanoid breakdown" EXACT []
synonym: "phenylpropanoid catabolism" EXACT []
synonym: "phenylpropanoid degradation" EXACT []
is_a: GO:0009698 ! phenylpropanoid metabolic process
is_a: GO:0019439 ! aromatic compound catabolic process
is_a: GO:0042219 ! cellular amino acid derivative catabolic process

[Term]
id: GO:0046272
name: stilbene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA." [GOC:ai]
subset: gosubset_prok
synonym: "stilbene breakdown" EXACT []
synonym: "stilbene catabolism" EXACT []
synonym: "stilbene degradation" EXACT []
is_a: GO:0009810 ! stilbene metabolic process
is_a: GO:0030640 ! polyketide catabolic process
is_a: GO:0043451 ! alkene catabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process

[Term]
id: GO:0046273
name: lignan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466]
subset: gosubset_prok
synonym: "lignan breakdown" EXACT []
synonym: "lignan catabolism" EXACT []
synonym: "lignan degradation" EXACT []
is_a: GO:0009806 ! lignan metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process

[Term]
id: GO:0046274
name: lignin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units." [GOC:ai]
subset: gosubset_prok
synonym: "lignin breakdown" EXACT []
synonym: "lignin catabolism" EXACT []
synonym: "lignin degradation" EXACT []
is_a: GO:0009808 ! lignin metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process

[Term]
id: GO:0046275
name: flavonoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GOC:ai]
subset: gosubset_prok
synonym: "flavonoid breakdown" EXACT []
synonym: "flavonoid catabolism" EXACT []
synonym: "flavonoid degradation" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process
is_a: GO:0046700 ! heterocycle catabolic process

[Term]
id: GO:0046276
name: methylgallate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai]
subset: gosubset_prok
synonym: "methylgallate breakdown" EXACT []
synonym: "methylgallate catabolism" EXACT []
synonym: "methylgallate degradation" EXACT []
xref: MetaCyc:METHYLGALLATE-DEGRADATION-PWY
is_a: GO:0019396 ! gallate catabolic process
is_a: GO:0019489 ! methylgallate metabolic process

[Term]
id: GO:0046277
name: methylgallate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai]
subset: gosubset_prok
synonym: "methylgallate anabolism" EXACT []
synonym: "methylgallate biosynthesis" EXACT []
synonym: "methylgallate formation" EXACT []
synonym: "methylgallate synthesis" EXACT []
is_a: GO:0019489 ! methylgallate metabolic process
is_a: GO:0046235 ! gallate biosynthetic process

[Term]
id: GO:0046278
name: protocatechuate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving protocatechuate, the anion of protocatechuic acid (3,4-dihydroxybenzoic acid)." [GOC:ai, http://chemfinder.cambridgesoft.com/]
subset: gosubset_prok
synonym: "protocatechuate metabolism" EXACT []
is_a: GO:0009712 ! catechol metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0046279
name: protocatechuate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of protocatechuate, the anion of 3,4-dihydroxybenzoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "protocatechuate anabolism" EXACT []
synonym: "protocatechuate biosynthesis" EXACT []
synonym: "protocatechuate formation" EXACT []
synonym: "protocatechuate synthesis" EXACT []
is_a: GO:0009713 ! catechol biosynthetic process
is_a: GO:0046278 ! protocatechuate metabolic process

[Term]
id: GO:0046280
name: chalcone catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of chalcone, phenyl steryl ketone or its hydroxylated derivatives." [GOC:ai]
subset: gosubset_prok
synonym: "chalcone breakdown" EXACT []
synonym: "chalcone catabolism" EXACT []
synonym: "chalcone degradation" EXACT []
is_a: GO:0009714 ! chalcone metabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process

[Term]
id: GO:0046281
name: cinnamic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "cinnamic acid breakdown" EXACT []
synonym: "cinnamic acid catabolism" EXACT []
synonym: "cinnamic acid degradation" EXACT []
synonym: "cinnamylic acid catabolic process" EXACT []
synonym: "cinnamylic acid catabolism" EXACT []
synonym: "phenylacrylic acid catabolic process" EXACT []
synonym: "phenylacrylic acid catabolism" EXACT []
is_a: GO:0009803 ! cinnamic acid metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process

[Term]
id: GO:0046282
name: cinnamic acid ester catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "cinnamic acid ester breakdown" EXACT []
synonym: "cinnamic acid ester catabolism" EXACT []
synonym: "cinnamic acid ester degradation" EXACT []
is_a: GO:0009801 ! cinnamic acid ester metabolic process
is_a: GO:0046271 ! phenylpropanoid catabolic process

[Term]
id: GO:0046283
name: anthocyanin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins that occur in plants. They are responsible from most of the scarlet, purple, mauve and blue coloring in higher plants, especially of flowers." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "anthocyanin metabolism" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0046284
name: anthocyanin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins." [GOC:ai]
subset: gosubset_prok
synonym: "anthocyanin breakdown" EXACT []
synonym: "anthocyanin catabolism" EXACT []
synonym: "anthocyanin degradation" EXACT []
is_a: GO:0046149 ! pigment catabolic process
is_a: GO:0046275 ! flavonoid catabolic process
is_a: GO:0046283 ! anthocyanin metabolic process

[Term]
id: GO:0046285
name: flavonoid phytoalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "flavonoid phytoalexin metabolism" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process

[Term]
id: GO:0046286
name: flavonoid phytoalexin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai]
subset: gosubset_prok
synonym: "flavonoid phytoalexin breakdown" EXACT []
synonym: "flavonoid phytoalexin catabolism" EXACT []
synonym: "flavonoid phytoalexin degradation" EXACT []
is_a: GO:0046275 ! flavonoid catabolic process
is_a: GO:0046285 ! flavonoid phytoalexin metabolic process
is_a: GO:0052316 ! phytoalexin catabolic process

[Term]
id: GO:0046287
name: isoflavonoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids, containing a flavan skeleton. They are differentiated from flavonoids by the point of attachment of the aromatic ring moiety." [GOC:ai, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "isoflavonoid metabolism" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0046288
name: isoflavonoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids." [GOC:ai]
subset: gosubset_prok
synonym: "isoflavonoid breakdown" EXACT []
synonym: "isoflavonoid catabolism" EXACT []
synonym: "isoflavonoid degradation" EXACT []
is_a: GO:0046275 ! flavonoid catabolic process
is_a: GO:0046287 ! isoflavonoid metabolic process

[Term]
id: GO:0046289
name: isoflavonoid phytoalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai]
subset: gosubset_prok
synonym: "isoflavonoid phytoalexin metabolism" EXACT []
is_a: GO:0046285 ! flavonoid phytoalexin metabolic process
is_a: GO:0046287 ! isoflavonoid metabolic process
is_a: GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0046290
name: isoflavonoid phytoalexin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai]
subset: gosubset_prok
synonym: "isoflavonoid phytoalexin breakdown" EXACT []
synonym: "isoflavonoid phytoalexin catabolism" EXACT []
synonym: "isoflavonoid phytoalexin degradation" EXACT []
is_a: GO:0046286 ! flavonoid phytoalexin catabolic process
is_a: GO:0046288 ! isoflavonoid catabolic process
is_a: GO:0046289 ! isoflavonoid phytoalexin metabolic process

[Term]
id: GO:0046291
name: 6-hydroxycineole biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai]
comment: This term was made obsolete because 6-hydroxycineole is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "6-endo-hydroxycineole biosynthesis" EXACT []
synonym: "6-endo-hydroxycineole biosynthetic process" EXACT []
synonym: "6-hydroxycineole anabolism" EXACT []
synonym: "6-hydroxycineole biosynthesis" EXACT []
synonym: "6-hydroxycineole formation" EXACT []
synonym: "6-hydroxycineole synthesis" EXACT []
synonym: "hydroxycineol biosynthesis" EXACT []
synonym: "hydroxycineol biosynthetic process" EXACT []
is_obsolete: true
replaced_by: GO:0019638

[Term]
id: GO:0046292
name: formaldehyde metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving formaldehyde (methanal, H2C=O), a colorless liquid or gas with a pungent odor, commonly used as a fixative or an antibacterial agent." [GOC:ai, http://cancerweb.ncl.ac.uk/, http://chemfinder.cambridgesoft.com/]
subset: gosubset_prok
synonym: "formaldehyde metabolism" EXACT []
synonym: "methanal metabolic process" EXACT []
synonym: "methanal metabolism" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0046293
name: formaldehyde biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai]
subset: gosubset_prok
synonym: "formaldehyde anabolism" EXACT []
synonym: "formaldehyde biosynthesis" EXACT []
synonym: "formaldehyde formation" EXACT []
synonym: "formaldehyde synthesis" EXACT []
synonym: "methanal biosynthesis" EXACT []
synonym: "methanal biosynthetic process" EXACT []
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:0046184 ! aldehyde biosynthetic process
is_a: GO:0046292 ! formaldehyde metabolic process

[Term]
id: GO:0046294
name: formaldehyde catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai]
subset: gosubset_prok
synonym: "formaldehyde breakdown" EXACT []
synonym: "formaldehyde catabolism" EXACT []
synonym: "formaldehyde degradation" EXACT []
synonym: "methanal catabolic process" EXACT []
synonym: "methanal catabolism" EXACT []
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0046185 ! aldehyde catabolic process
is_a: GO:0046292 ! formaldehyde metabolic process

[Term]
id: GO:0046295
name: glycolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai]
subset: gosubset_prok
synonym: "glycolate anabolism" EXACT []
synonym: "glycolate biosynthesis" EXACT []
synonym: "glycolate formation" EXACT []
synonym: "glycolate synthesis" EXACT []
is_a: GO:0009441 ! glycolate metabolic process
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0046296
name: glycolate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai]
subset: gosubset_prok
synonym: "glycolate breakdown" EXACT []
synonym: "glycolate catabolism" EXACT []
synonym: "glycolate degradation" EXACT []
is_a: GO:0009441 ! glycolate metabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0046297
name: 2,4-dichlorobenzoate biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:ai]
comment: This term was made obsolete because 2,4-dichlorobenzoate is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "2,4-dichlorobenzoate anabolism" EXACT []
synonym: "2,4-dichlorobenzoate biosynthesis" EXACT []
synonym: "2,4-dichlorobenzoate formation" EXACT []
synonym: "2,4-dichlorobenzoate synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018898

[Term]
id: GO:0046298
name: 2,4-dichlorobenzoate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:ai]
subset: gosubset_prok
synonym: "2,4-dichlorobenzoate breakdown" EXACT []
synonym: "2,4-dichlorobenzoate catabolism" EXACT []
synonym: "2,4-dichlorobenzoate degradation" EXACT []
is_a: GO:0018898 ! 2,4-dichlorobenzoate metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process
is_a: GO:0046413 ! organomercury catabolic process

[Term]
id: GO:0046299
name: 2,4-dichlorophenoxyacetic acid biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:ai]
comment: This term was made obsolete because 2,4-dichlorophenoxyacetic acid is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "2,4-dichlorophenoxyacetic acid anabolism" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid biosynthesis" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid formation" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018901

[Term]
id: GO:0046300
name: 2,4-dichlorophenoxyacetic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:ai]
subset: gosubset_prok
synonym: "2,4-dichlorophenoxyacetic acid breakdown" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid catabolism" EXACT []
synonym: "2,4-dichlorophenoxyacetic acid degradation" EXACT []
is_a: GO:0018901 ! 2,4-dichlorophenoxyacetic acid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process

[Term]
id: GO:0046301
name: 2-chloro-N-isopropylacetanilide biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [GOC:ai]
comment: This term was made obsolete because 2-chloro-N-isopropylacetanilide is not synthesized by living organisms and GO does not cover non-biological processes.
synonym: "2-chloro-N-isopropylacetanilide anabolism" EXACT []
synonym: "2-chloro-N-isopropylacetanilide biosynthesis" EXACT []
synonym: "2-chloro-N-isopropylacetanilide formation" EXACT []
synonym: "2-chloro-N-isopropylacetanilide synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018889

[Term]
id: GO:0046302
name: 2-chloro-N-isopropylacetanilide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [GOC:ai]
subset: gosubset_prok
synonym: "2-chloro-N-isopropylacetanilide breakdown" EXACT []
synonym: "2-chloro-N-isopropylacetanilide catabolism" EXACT []
synonym: "2-chloro-N-isopropylacetanilide degradation" EXACT []
is_a: GO:0018889 ! 2-chloro-N-isopropylacetanilide metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process

[Term]
id: GO:0046303
name: 2-nitropropane biosynthetic process
namespace: biological_process
def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor." [GOC:ai]
comment: This term was made obsolete because 2-nitropropane is not synthesized by living organisms, and GO does not cover non-biological processes.
synonym: "2-nitropropane anabolism" EXACT []
synonym: "2-nitropropane biosynthesis" EXACT []
synonym: "2-nitropropane formation" EXACT []
synonym: "2-nitropropane synthesis" EXACT []
is_obsolete: true
replaced_by: GO:0018938

[Term]
id: GO:0046304
name: 2-nitropropane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor." [GOC:ai]
subset: gosubset_prok
synonym: "2-nitropropane breakdown" EXACT []
synonym: "2-nitropropane catabolism" EXACT []
synonym: "2-nitropropane degradation" EXACT []
is_a: GO:0018938 ! 2-nitropropane metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process
is_a: GO:0043448 ! alkane catabolic process
is_a: GO:0044270 ! cellular nitrogen compound catabolic process

[Term]
id: GO:0046305
name: alkanesulfonate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon moiety." [GOC:ai]
subset: gosubset_prok
synonym: "alkanesulfonate anabolism" EXACT []
synonym: "alkanesulfonate biosynthesis" EXACT []
synonym: "alkanesulfonate formation" EXACT []
synonym: "alkanesulfonate synthesis" EXACT []
synonym: "alkanesulphonate biosynthesis" EXACT []
synonym: "alkanesulphonate biosynthetic process" EXACT []
is_a: GO:0019694 ! alkanesulfonate metabolic process
is_a: GO:0044272 ! sulfur compound biosynthetic process

[Term]
id: GO:0046306
name: alkanesulfonate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon moiety." [GOC:ai]
subset: gosubset_prok
synonym: "alkanesulfonate breakdown" EXACT []
synonym: "alkanesulfonate catabolism" EXACT []
synonym: "alkanesulfonate degradation" EXACT []
synonym: "alkanesulphonate catabolic process" EXACT []
synonym: "alkanesulphonate catabolism" EXACT []
is_a: GO:0019694 ! alkanesulfonate metabolic process
is_a: GO:0044273 ! sulfur compound catabolic process

[Term]
id: GO:0046307
name: Z-phenylacetaldoxime biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds." [GOC:ai]
subset: gosubset_prok
synonym: "Z-phenylacetaldoxime anabolism" EXACT []
synonym: "Z-phenylacetaldoxime biosynthesis" EXACT []
synonym: "Z-phenylacetaldoxime formation" EXACT []
synonym: "Z-phenylacetaldoxime synthesis" EXACT []
is_a: GO:0018983 ! Z-phenylacetaldoxime metabolic process
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process

[Term]
id: GO:0046308
name: Z-phenylacetaldoxime catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds." [GOC:ai]
subset: gosubset_prok
synonym: "Z-phenylacetaldoxime breakdown" EXACT []
synonym: "Z-phenylacetaldoxime catabolism" EXACT []
synonym: "Z-phenylacetaldoxime degradation" EXACT []
is_a: GO:0018983 ! Z-phenylacetaldoxime metabolic process
is_a: GO:0042219 ! cellular amino acid derivative catabolic process

[Term]
id: GO:0046309
name: 1,3-dichloro-2-propanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic." [GOC:ai]
subset: gosubset_prok
synonym: "1,3-dichloro-2-propanol anabolism" EXACT []
synonym: "1,3-dichloro-2-propanol biosynthesis" EXACT []
synonym: "1,3-dichloro-2-propanol formation" EXACT []
synonym: "1,3-dichloro-2-propanol synthesis" EXACT []
is_a: GO:0018902 ! 1,3-dichloro-2-propanol metabolic process
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process

[Term]
id: GO:0046310
name: 1,3-dichloro-2-propanol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic." [GOC:ai]
subset: gosubset_prok
synonym: "1,3-dichloro-2-propanol breakdown" EXACT []
synonym: "1,3-dichloro-2-propanol catabolism" EXACT []
synonym: "1,3-dichloro-2-propanol degradation" EXACT []
is_a: GO:0018902 ! 1,3-dichloro-2-propanol metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process
is_a: GO:0042219 ! cellular amino acid derivative catabolic process

[Term]
id: GO:0046311
name: prenylcysteine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai]
subset: gosubset_prok
synonym: "prenylcysteine anabolism" EXACT []
synonym: "prenylcysteine biosynthesis" EXACT []
synonym: "prenylcysteine formation" EXACT []
synonym: "prenylcysteine synthesis" EXACT []
is_a: GO:0030329 ! prenylcysteine metabolic process
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process

[Term]
id: GO:0046312
name: phosphoarginine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphoarginine, a phosphorylated derivative of the amino acid arginine." [GOC:ai]
subset: gosubset_prok
synonym: "phosphoarginine anabolism" EXACT []
synonym: "phosphoarginine biosynthesis" EXACT []
synonym: "phosphoarginine formation" EXACT []
synonym: "phosphoarginine synthesis" EXACT []
is_a: GO:0006604 ! phosphoarginine metabolic process
is_a: GO:0042396 ! phosphagen biosynthetic process

[Term]
id: GO:0046313
name: phosphoarginine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphoarginine, a phosphorylated derivative of the amino acid arginine." [GOC:ai]
subset: gosubset_prok
synonym: "phosphoarginine breakdown" EXACT []
synonym: "phosphoarginine catabolism" EXACT []
synonym: "phosphoarginine degradation" EXACT []
is_a: GO:0006604 ! phosphoarginine metabolic process
is_a: GO:0042397 ! phosphagen catabolic process

[Term]
id: GO:0046314
name: phosphocreatine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]
subset: gosubset_prok
synonym: "phosphocreatine anabolism" EXACT []
synonym: "phosphocreatine biosynthesis" EXACT []
synonym: "phosphocreatine formation" EXACT []
synonym: "phosphocreatine synthesis" EXACT []
is_a: GO:0006603 ! phosphocreatine metabolic process
is_a: GO:0042396 ! phosphagen biosynthetic process

[Term]
id: GO:0046315
name: phosphocreatine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai]
subset: gosubset_prok
synonym: "phosphocreatine breakdown" EXACT []
synonym: "phosphocreatine catabolism" EXACT []
synonym: "phosphocreatine degradation" EXACT []
is_a: GO:0006603 ! phosphocreatine metabolic process
is_a: GO:0042397 ! phosphagen catabolic process

[Term]
id: GO:0046316
name: gluconokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-gluconate = ADP + 6-phospho-D-gluconate." [EC:2.7.1.12]
subset: gosubset_prok
synonym: "ATP:D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.12]
synonym: "gluconate kinase activity" EXACT [EC:2.7.1.12]
synonym: "gluconokinase (phosphorylating)" EXACT [EC:2.7.1.12]
xref: EC:2.7.1.12
xref: MetaCyc:GLUCONOKIN-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0046317
name: regulation of glucosylceramide biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "regulation of glucosylceramide anabolism" EXACT []
synonym: "regulation of glucosylceramide biosynthesis" EXACT []
synonym: "regulation of glucosylceramide formation" EXACT []
synonym: "regulation of glucosylceramide synthesis" EXACT []
is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process
relationship: regulates GO:0006679 ! glucosylceramide biosynthetic process

[Term]
id: GO:0046318
name: negative regulation of glucosylceramide biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of glucosylceramide biosynthetic process" EXACT []
synonym: "down-regulation of glucosylceramide biosynthetic process" EXACT []
synonym: "downregulation of glucosylceramide biosynthetic process" EXACT []
synonym: "inhibition of glucosylceramide biosynthetic process" NARROW []
synonym: "negative regulation of glucosylceramide anabolism" EXACT []
synonym: "negative regulation of glucosylceramide biosynthesis" EXACT []
synonym: "negative regulation of glucosylceramide formation" EXACT []
synonym: "negative regulation of glucosylceramide synthesis" EXACT []
is_a: GO:0046317 ! regulation of glucosylceramide biosynthetic process
is_a: GO:0090155 ! negative regulation of sphingolipid biosynthetic process
relationship: negatively_regulates GO:0006679 ! glucosylceramide biosynthetic process

[Term]
id: GO:0046319
name: positive regulation of glucosylceramide biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai]
subset: gosubset_prok
synonym: "activation of glucosylceramide biosynthetic process" NARROW []
synonym: "positive regulation of glucosylceramide anabolism" EXACT []
synonym: "positive regulation of glucosylceramide biosynthesis" EXACT []
synonym: "positive regulation of glucosylceramide formation" EXACT []
synonym: "positive regulation of glucosylceramide synthesis" EXACT []
synonym: "stimulation of glucosylceramide biosynthetic process" NARROW []
synonym: "up regulation of glucosylceramide biosynthetic process" EXACT []
synonym: "up-regulation of glucosylceramide biosynthetic process" EXACT []
synonym: "upregulation of glucosylceramide biosynthetic process" EXACT []
is_a: GO:0046317 ! regulation of glucosylceramide biosynthetic process
is_a: GO:0090154 ! positive regulation of sphingolipid biosynthetic process
relationship: positively_regulates GO:0006679 ! glucosylceramide biosynthetic process

[Term]
id: GO:0046320
name: regulation of fatty acid oxidation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fatty acid oxidation." [GOC:ai]
subset: gosubset_prok
xref: Reactome:200409 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:448700 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:469822 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:487516 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:507477 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:517461 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:526335 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:531320 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:536703 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:542439 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:547788 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:552346 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:557950 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:568590 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:581796 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:585902 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:592708 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:595460 "Activated AMPK stimulates fatty-acid oxidation in muscle"
xref: Reactome:602539 "Activated AMPK stimulates fatty-acid oxidation in muscle"
is_a: GO:0019217 ! regulation of fatty acid metabolic process
relationship: regulates GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0046321
name: positive regulation of fatty acid oxidation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of fatty acid oxidation." [GOC:ai]
subset: gosubset_prok
synonym: "activation of fatty acid oxidation" NARROW []
synonym: "stimulation of fatty acid oxidation" NARROW []
synonym: "up regulation of fatty acid oxidation" EXACT []
synonym: "up-regulation of fatty acid oxidation" EXACT []
synonym: "upregulation of fatty acid oxidation" EXACT []
is_a: GO:0045923 ! positive regulation of fatty acid metabolic process
is_a: GO:0046320 ! regulation of fatty acid oxidation
relationship: positively_regulates GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0046322
name: negative regulation of fatty acid oxidation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fatty acid oxidation." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of fatty acid oxidation" EXACT []
synonym: "down-regulation of fatty acid oxidation" EXACT []
synonym: "downregulation of fatty acid oxidation" EXACT []
synonym: "inhibition of fatty acid oxidation" NARROW []
is_a: GO:0045922 ! negative regulation of fatty acid metabolic process
is_a: GO:0046320 ! regulation of fatty acid oxidation
relationship: negatively_regulates GO:0019395 ! fatty acid oxidation

[Term]
id: GO:0046323
name: glucose import
namespace: biological_process
def: "The directed movement of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai]
subset: gosubset_prok
synonym: "glucose uptake" EXACT [GOC:dph, GOC:tb]
xref: Reactome:448792 "Glucose uptake"
xref: Reactome:469907 "Glucose uptake"
xref: Reactome:487614 "Glucose uptake"
xref: Reactome:507569 "Glucose uptake"
xref: Reactome:517543 "Glucose uptake"
xref: Reactome:526410 "Glucose uptake"
xref: Reactome:531233 "Glucose uptake"
xref: Reactome:536602 "Glucose uptake"
xref: Reactome:542328 "Glucose uptake"
xref: Reactome:547711 "Glucose uptake"
xref: Reactome:552253 "Glucose uptake"
xref: Reactome:557872 "Glucose uptake"
xref: Reactome:568470 "Glucose uptake"
xref: Reactome:581681 "Glucose uptake"
xref: Reactome:585860 "Glucose uptake"
xref: Reactome:595400 "Glucose uptake"
xref: Reactome:70153 "Glucose uptake"
xref: Wikipedia:Glucose_uptake
is_a: GO:0015758 ! glucose transport

[Term]
id: GO:0046324
name: regulation of glucose import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of glucose uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010827 ! regulation of glucose transport
relationship: regulates GO:0046323 ! glucose import

[Term]
id: GO:0046325
name: negative regulation of glucose import
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai]
synonym: "down regulation of glucose import" EXACT []
synonym: "down-regulation of glucose import" EXACT []
synonym: "downregulation of glucose import" EXACT []
synonym: "inhibition of glucose import" NARROW []
synonym: "negative regulation of glucose uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010829 ! negative regulation of glucose transport
is_a: GO:0046324 ! regulation of glucose import
relationship: negatively_regulates GO:0046323 ! glucose import

[Term]
id: GO:0046326
name: positive regulation of glucose import
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai]
subset: gosubset_prok
synonym: "activation of glucose import" NARROW []
synonym: "positive regulation of glucose uptake" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of glucose import" NARROW []
synonym: "up regulation of glucose import" EXACT []
synonym: "up-regulation of glucose import" EXACT []
synonym: "upregulation of glucose import" EXACT []
xref: GOC:dph
xref: GOC:tb
is_a: GO:0010828 ! positive regulation of glucose transport
is_a: GO:0046324 ! regulation of glucose import
relationship: positively_regulates GO:0046323 ! glucose import

[Term]
id: GO:0046327
name: glycerol biosynthetic process from pyruvate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, from other compounds, including pyruvate." [GOC:ai]
subset: gosubset_prok
synonym: "glycerol anabolism from pyruvate" EXACT []
synonym: "glycerol formation from pyruvate" EXACT []
synonym: "glycerol synthesis from pyruvate" EXACT []
synonym: "glyceroneogenesis" EXACT []
is_a: GO:0006090 ! pyruvate metabolic process
is_a: GO:0006114 ! glycerol biosynthetic process
relationship: part_of GO:0019432 ! triglyceride biosynthetic process

[Term]
id: GO:0046328
name: regulation of JNK cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
synonym: "regulation of SAPK cascade" BROAD []
is_a: GO:0043408 ! regulation of MAPKKK cascade
is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling pathway
relationship: regulates GO:0007254 ! JNK cascade

[Term]
id: GO:0046329
name: negative regulation of JNK cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
synonym: "down regulation of JNK cascade" EXACT []
synonym: "down-regulation of JNK cascade" EXACT []
synonym: "downregulation of JNK cascade" EXACT []
synonym: "inhibition of JNK cascade" NARROW []
is_a: GO:0043409 ! negative regulation of MAPKKK cascade
is_a: GO:0046328 ! regulation of JNK cascade
is_a: GO:0070303 ! negative regulation of stress-activated protein kinase signaling pathway
relationship: negatively_regulates GO:0007254 ! JNK cascade

[Term]
id: GO:0046330
name: positive regulation of JNK cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf]
synonym: "activation of JNK cascade" NARROW []
synonym: "stimulation of JNK cascade" NARROW []
synonym: "up regulation of JNK cascade" EXACT []
synonym: "up-regulation of JNK cascade" EXACT []
synonym: "upregulation of JNK cascade" EXACT []
is_a: GO:0043410 ! positive regulation of MAPKKK cascade
is_a: GO:0046328 ! regulation of JNK cascade
is_a: GO:0070304 ! positive regulation of stress-activated protein kinase signaling pathway
relationship: positively_regulates GO:0007254 ! JNK cascade

[Term]
id: GO:0046331
name: lateral inhibition
namespace: biological_process
def: "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv]
is_a: GO:0045168 ! cell-cell signaling involved in cell fate specification

[Term]
id: GO:0046332
name: SMAD binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a SMAD signaling protein." [GOC:ai]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0046333
name: octopamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepihephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "octopamine metabolism" EXACT []
is_a: GO:0018958 ! phenol metabolic process
is_a: GO:0042133 ! neurotransmitter metabolic process
is_a: GO:0042439 ! ethanolamine and derivative metabolic process

[Term]
id: GO:0046334
name: octopamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepihephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "octopamine breakdown" EXACT []
synonym: "octopamine catabolism" EXACT []
synonym: "octopamine degradation" EXACT []
is_a: GO:0019336 ! phenol catabolic process
is_a: GO:0042135 ! neurotransmitter catabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
is_a: GO:0046333 ! octopamine metabolic process

[Term]
id: GO:0046335
name: ethanolamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [GOC:ai]
subset: gosubset_prok
synonym: "ethanolamine anabolism" EXACT []
synonym: "ethanolamine biosynthesis" EXACT []
synonym: "ethanolamine formation" EXACT []
synonym: "ethanolamine synthesis" EXACT []
is_a: GO:0006580 ! ethanolamine metabolic process
is_a: GO:0042401 ! cellular biogenic amine biosynthetic process

[Term]
id: GO:0046336
name: ethanolamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [GOC:ai]
subset: gosubset_prok
synonym: "ethanolamine breakdown" EXACT []
synonym: "ethanolamine catabolism" EXACT []
synonym: "ethanolamine degradation" EXACT []
is_a: GO:0006580 ! ethanolamine metabolic process
is_a: GO:0042402 ! cellular biogenic amine catabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0046337
name: phosphatidylethanolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphatidylethanolamine metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0009308 ! amine metabolic process

[Term]
id: GO:0046338
name: phosphatidylethanolamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphatidylethanolamine breakdown" EXACT []
synonym: "phosphatidylethanolamine catabolism" EXACT []
synonym: "phosphatidylethanolamine degradation" EXACT []
is_a: GO:0046336 ! ethanolamine catabolic process
is_a: GO:0046337 ! phosphatidylethanolamine metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process

[Term]
id: GO:0046339
name: diacylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues. DAG is a normal intermediate in the biosynthesis of phosphatidyl phospholipids and is released from them by phospholipase C activity. DAG from phosphatidyl inositol polyphosphates is important in signal transduction." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "diacylglycerol metabolism" EXACT []
is_a: GO:0006639 ! acylglycerol metabolic process

[Term]
id: GO:0046340
name: diacylglycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "diacylglycerol breakdown" EXACT []
synonym: "diacylglycerol catabolism" EXACT []
synonym: "diacylglycerol degradation" EXACT []
is_a: GO:0046339 ! diacylglycerol metabolic process
is_a: GO:0046464 ! acylglycerol catabolic process

[Term]
id: GO:0046341
name: CDP-diacylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "CDP-diacylglycerol metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0046339 ! diacylglycerol metabolic process

[Term]
id: GO:0046342
name: CDP-diacylglycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "CDP-diacylglycerol breakdown" EXACT []
synonym: "CDP-diacylglycerol catabolism" EXACT []
synonym: "CDP-diacylglycerol degradation" EXACT []
is_a: GO:0046340 ! diacylglycerol catabolic process
is_a: GO:0046341 ! CDP-diacylglycerol metabolic process
is_a: GO:0046475 ! glycerophospholipid catabolic process

[Term]
id: GO:0046343
name: streptomycin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving streptomycin, a commonly used antibiotic in cell culture media. It acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "streptomycin metabolism" EXACT []
is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process

[Term]
id: GO:0046344
name: ecdysteroid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:ai]
synonym: "ecdysteroid breakdown" EXACT []
synonym: "ecdysteroid catabolism" EXACT []
synonym: "ecdysteroid degradation" EXACT []
is_a: GO:0006706 ! steroid catabolic process
is_a: GO:0042182 ! ketone catabolic process
is_a: GO:0042447 ! hormone catabolic process
is_a: GO:0045455 ! ecdysteroid metabolic process

[Term]
id: GO:0046345
name: abscisic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "abscisic acid breakdown" EXACT []
synonym: "abscisic acid catabolism" EXACT []
synonym: "abscisic acid degradation" EXACT []
is_a: GO:0009687 ! abscisic acid metabolic process
is_a: GO:0016107 ! sesquiterpenoid catabolic process
is_a: GO:0043290 ! apocarotenoid catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0046346
name: mannosamine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "mannosamine breakdown" EXACT []
synonym: "mannosamine catabolism" EXACT []
synonym: "mannosamine degradation" EXACT []
is_a: GO:0006050 ! mannosamine metabolic process
is_a: GO:0046348 ! amino sugar catabolic process

[Term]
id: GO:0046347
name: mannosamine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "mannosamine anabolism" EXACT []
synonym: "mannosamine biosynthesis" EXACT []
synonym: "mannosamine formation" EXACT []
synonym: "mannosamine synthesis" EXACT []
is_a: GO:0006050 ! mannosamine metabolic process
is_a: GO:0046349 ! amino sugar biosynthetic process

[Term]
id: GO:0046348
name: amino sugar catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "amino sugar breakdown" EXACT []
synonym: "amino sugar catabolism" EXACT []
synonym: "amino sugar degradation" EXACT []
synonym: "aminosaccharide catabolic process" EXACT []
synonym: "aminosaccharide catabolism" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:0046365 ! monosaccharide catabolic process

[Term]
id: GO:0046349
name: amino sugar biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "amino sugar anabolism" EXACT []
synonym: "amino sugar biosynthesis" EXACT []
synonym: "amino sugar formation" EXACT []
synonym: "amino sugar synthesis" EXACT []
synonym: "aminosaccharide biosynthesis" EXACT []
synonym: "aminosaccharide biosynthetic process" EXACT []
is_a: GO:0006040 ! amino sugar metabolic process
is_a: GO:0046364 ! monosaccharide biosynthetic process

[Term]
id: GO:0046350
name: galactosaminoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactosaminoglycans, any one of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai]
subset: gosubset_prok
synonym: "galactosaminoglycan metabolism" EXACT []
is_a: GO:0030203 ! glycosaminoglycan metabolic process

[Term]
id: GO:0046351
name: disaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of disaccharides, sugars composed of two monosaccharide units." [GOC:ai]
subset: gosubset_prok
synonym: "disaccharide anabolism" EXACT []
synonym: "disaccharide biosynthesis" EXACT []
synonym: "disaccharide formation" EXACT []
synonym: "disaccharide synthesis" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process
is_a: GO:0009312 ! oligosaccharide biosynthetic process
is_a: GO:0034637 ! cellular carbohydrate biosynthetic process

[Term]
id: GO:0046352
name: disaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of disaccharides, sugars composed of two monosaccharide units." [GOC:ai]
subset: gosubset_prok
synonym: "disaccharide breakdown" EXACT []
synonym: "disaccharide catabolism" EXACT []
synonym: "disaccharide degradation" EXACT []
is_a: GO:0005984 ! disaccharide metabolic process
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process

[Term]
id: GO:0046353
name: aminoglycoside 3-N-acetyltransferase activity
namespace: molecular_function
alt_id: GO:0016991
def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 3-N-acetylaminoglycoside. This is acetylation of the 3-amino group of the central deoxystreptamine ring." [GOC:cb]
subset: gosubset_prok
synonym: "3'-aminoglycoside acetyltransferase activity" RELATED [EC:2.3.1.81]
synonym: "3-N-aminoglycoside acetyltransferase activity" EXACT [EC:2.3.1.81]
synonym: "acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase activity" EXACT [EC:2.3.1.81]
synonym: "acetyl-CoA:gentamicin-C N3'-acetyltransferase activity" NARROW [EC:2.3.1.60]
synonym: "aminoglycoside acetyltransferase AAC(3)-1" RELATED [EC:2.3.1.60]
synonym: "aminoglycoside acetyltransferase AAC(3)-I activity" RELATED [EC:2.3.1.60]
synonym: "gentamicin 3'-N-acetyltransferase activity" NARROW []
synonym: "gentamicin acetyltransferase I activity" NARROW [EC:2.3.1.60]
synonym: "gentamicin-(3)-N-acetyltransferase activity" NARROW [EC:2.3.1.81]
synonym: "gentamycin 3'-N-acetyltransferase activity" EXACT []
synonym: "gentamycin acetyltransferase I" RELATED [EC:2.3.1.60]
xref: EC:2.3.1.60
xref: EC:2.3.1.81
xref: MetaCyc:AMINOGLYCOSIDE-N3-ACETYLTRANSFERASE-RXN
xref: MetaCyc:GENTAMICIN-3-N-ACETYLTRANSFERASE-RXN
is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity

[Term]
id: GO:0046354
name: mannan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "mannan anabolism" EXACT []
synonym: "mannan biosynthesis" EXACT []
synonym: "mannan formation" EXACT []
synonym: "mannan synthesis" EXACT []
is_a: GO:0010412 ! mannan metabolic process
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process

[Term]
id: GO:0046355
name: mannan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "mannan breakdown" EXACT []
synonym: "mannan catabolism" EXACT []
synonym: "mannan degradation" EXACT []
is_a: GO:0010412 ! mannan metabolic process
is_a: GO:0044039 ! cellular cell wall macromolecule catabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process

[Term]
id: GO:0046356
name: acetyl-CoA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:ai]
subset: gosubset_prok
synonym: "acetyl-CoA breakdown" EXACT []
synonym: "acetyl-CoA catabolism" EXACT []
synonym: "acetyl-CoA degradation" EXACT []
is_a: GO:0006084 ! acetyl-CoA metabolic process
is_a: GO:0009109 ! coenzyme catabolic process

[Term]
id: GO:0046357
name: galactarate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactarate, the anion of galactaric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "galactarate anabolism" EXACT []
synonym: "galactarate biosynthesis" EXACT []
synonym: "galactarate formation" EXACT []
synonym: "galactarate synthesis" EXACT []
is_a: GO:0019578 ! aldaric acid biosynthetic process
is_a: GO:0019580 ! galactarate metabolic process

[Term]
id: GO:0046358
name: butyrate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of butyrate, the anion of butyric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "butyrate anabolism" EXACT []
synonym: "butyrate biosynthesis" EXACT []
synonym: "butyrate formation" EXACT []
synonym: "butyrate synthesis" EXACT []
is_a: GO:0019605 ! butyrate metabolic process
is_a: GO:0051790 ! short-chain fatty acid biosynthetic process

[Term]
id: GO:0046359
name: butyrate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of butyrate, the anion of butyric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "butyrate breakdown" EXACT []
synonym: "butyrate catabolism" EXACT []
synonym: "butyrate degradation" EXACT []
is_a: GO:0019605 ! butyrate metabolic process
is_a: GO:0019626 ! short-chain fatty acid catabolic process

[Term]
id: GO:0046360
name: 2-oxobutyrate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "2-oxobutyrate anabolism" EXACT []
synonym: "2-oxobutyrate biosynthesis" EXACT []
synonym: "2-oxobutyrate formation" EXACT []
synonym: "2-oxobutyrate synthesis" EXACT []
synonym: "alpha-ketobutyrate biosynthesis" EXACT []
synonym: "alpha-ketobutyrate biosynthetic process" EXACT []
is_a: GO:0046358 ! butyrate biosynthetic process
is_a: GO:0046361 ! 2-oxobutyrate metabolic process

[Term]
id: GO:0046361
name: 2-oxobutyrate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [http://chemfinder.cambridgesoft.com/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "2-oxobutyrate metabolism" EXACT []
synonym: "alpha-ketobutyrate metabolic process" EXACT []
synonym: "alpha-ketobutyrate metabolism" EXACT []
is_a: GO:0019605 ! butyrate metabolic process

[Term]
id: GO:0046362
name: ribitol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ribitol anabolism" EXACT []
synonym: "ribitol biosynthesis" EXACT []
synonym: "ribitol formation" EXACT []
synonym: "ribitol synthesis" EXACT []
is_a: GO:0019322 ! pentose biosynthetic process
is_a: GO:0019349 ! ribitol metabolic process
is_a: GO:0019526 ! pentitol biosynthetic process

[Term]
id: GO:0046363
name: ribitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ribitol breakdown" EXACT []
synonym: "ribitol catabolism" EXACT []
synonym: "ribitol degradation" EXACT []
is_a: GO:0019323 ! pentose catabolic process
is_a: GO:0019349 ! ribitol metabolic process
is_a: GO:0019527 ! pentitol catabolic process

[Term]
id: GO:0046364
name: monosaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "monosaccharide anabolism" EXACT []
synonym: "monosaccharide biosynthesis" EXACT []
synonym: "monosaccharide formation" EXACT []
synonym: "monosaccharide synthesis" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0034637 ! cellular carbohydrate biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process

[Term]
id: GO:0046365
name: monosaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "monosaccharide breakdown" EXACT []
synonym: "monosaccharide catabolism" EXACT []
synonym: "monosaccharide degradation" EXACT []
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process
is_a: GO:0046164 ! alcohol catabolic process

[Term]
id: GO:0046366
name: allose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "allose anabolism" EXACT []
synonym: "allose biosynthesis" EXACT []
synonym: "allose formation" EXACT []
synonym: "allose synthesis" EXACT []
is_a: GO:0019313 ! allose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0046367
name: allose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "allose breakdown" EXACT []
synonym: "allose catabolism" EXACT []
synonym: "allose degradation" EXACT []
is_a: GO:0019313 ! allose metabolic process
is_a: GO:0019320 ! hexose catabolic process

[Term]
id: GO:0046368
name: GDP-L-fucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP-L-fucose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:0042354 ! L-fucose metabolic process

[Term]
id: GO:0046369
name: galactose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactose, the aldohexose galacto-hexose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "galactose anabolism" EXACT []
synonym: "galactose biosynthesis" EXACT []
synonym: "galactose formation" EXACT []
synonym: "galactose synthesis" EXACT []
is_a: GO:0006012 ! galactose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0046370
name: fructose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose." [GOC:ai]
subset: gosubset_prok
synonym: "fructose anabolism" EXACT []
synonym: "fructose biosynthesis" EXACT []
synonym: "fructose formation" EXACT []
synonym: "fructose synthesis" EXACT []
is_a: GO:0006000 ! fructose metabolic process
is_a: GO:0019319 ! hexose biosynthetic process

[Term]
id: GO:0046371
name: dTDP-mannose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "dTDP-mannose metabolism" EXACT []
is_a: GO:0006013 ! mannose metabolic process
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0046372
name: D-arabinose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-arabinose, the D-enantiomer of arabino-pentose. D-arabinose occurs in plant glycosides and is a constituent of arabinonucleosides." [ChEBI:17108, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-arabinose metabolism" EXACT []
is_a: GO:0019566 ! arabinose metabolic process

[Term]
id: GO:0046373
name: L-arabinose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-arabinose, the D-enantiomer of arabino-pentose. L-arabinose occurs free, e.g. in the heartwood of many conifers, and in the combined state, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides etc." [ChEBI:30849, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "L-arabinose metabolism" EXACT []
is_a: GO:0019566 ! arabinose metabolic process

[Term]
id: GO:0046374
name: teichoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "teichoic acid metabolism" EXACT []
is_a: GO:0005976 ! polysaccharide metabolic process

[Term]
id: GO:0046375
name: K antigen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "K antigen metabolism" EXACT []
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0046376
name: GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolism" EXACT []
is_a: GO:0019348 ! dolichol metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0046377
name: colanic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving colanic acid, a capsular bacterial polysaccharide composed of glucose, galactose, fucose and glucuronic acid residues." [GOC:ai, http://www.science.siu.edu/microbiology/micr425/425Notes/02-CellEnv.html]
subset: gosubset_prok
synonym: "colanic acid metabolism" EXACT []
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0046378
name: enterobacterial common antigen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria." [GOC:ma]
subset: gosubset_prok
synonym: "enterobacterial common antigen metabolism" EXACT []
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0046379
name: extracellular polysaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving polysaccharides used in extracellular structures." [GOC:ai]
subset: gosubset_prok
synonym: "extracellular polysaccharide metabolism" EXACT []
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0046380
name: N-acetylneuraminate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "N-acetylneuraminate anabolism" EXACT []
synonym: "N-acetylneuraminate biosynthesis" EXACT []
synonym: "N-acetylneuraminate formation" EXACT []
synonym: "N-acetylneuraminate synthesis" EXACT []
is_a: GO:0006054 ! N-acetylneuraminate metabolic process
is_a: GO:0046349 ! amino sugar biosynthetic process

[Term]
id: GO:0046381
name: CMP-N-acetylneuraminate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai]
subset: gosubset_prok
synonym: "CMP-N-acetylneuraminate metabolism" EXACT []
is_a: GO:0006054 ! N-acetylneuraminate metabolic process
is_a: GO:0009225 ! nucleotide-sugar metabolic process

[Term]
id: GO:0046382
name: GDP-D-rhamnose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP-D-rhamnose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:0019299 ! rhamnose metabolic process

[Term]
id: GO:0046383
name: dTDP-rhamnose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "dTDP-rhamnose metabolism" EXACT []
is_a: GO:0009225 ! nucleotide-sugar metabolic process
is_a: GO:0019299 ! rhamnose metabolic process

[Term]
id: GO:0046384
name: 2-deoxyribose 1-phosphate metabolic process
namespace: biological_process
alt_id: GO:0046388
def: "The chemical reactions and pathways involving 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "2-deoxyribose 1-phosphate metabolism" EXACT []
synonym: "deoxyribose 1-phosphate metabolic process" EXACT []
synonym: "deoxyribose 1-phosphate metabolism" EXACT []
is_a: GO:0019692 ! deoxyribose phosphate metabolic process

[Term]
id: GO:0046385
name: deoxyribose phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "deoxyribose phosphate anabolism" EXACT []
synonym: "deoxyribose phosphate biosynthesis" EXACT []
synonym: "deoxyribose phosphate formation" EXACT []
synonym: "deoxyribose phosphate synthesis" EXACT []
is_a: GO:0019302 ! D-ribose biosynthetic process
is_a: GO:0019692 ! deoxyribose phosphate metabolic process

[Term]
id: GO:0046386
name: deoxyribose phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "deoxyribose phosphate breakdown" EXACT []
synonym: "deoxyribose phosphate catabolism" EXACT []
synonym: "deoxyribose phosphate degradation" EXACT []
is_a: GO:0019303 ! D-ribose catabolic process
is_a: GO:0019692 ! deoxyribose phosphate metabolic process

[Term]
id: GO:0046387
name: deoxyribose 1,5-bisphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose." [GOC:ai]
subset: gosubset_prok
synonym: "deoxyribose 1,5-bisphosphate metabolism" EXACT []
is_a: GO:0019692 ! deoxyribose phosphate metabolic process

[Term]
id: GO:0046389
name: deoxyribose 5-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving deoxyribose 5-phosphate, the phosphorylated sugar 5-phospho-2-deoxyribose." [GOC:ai]
subset: gosubset_prok
synonym: "deoxyribose 5-phosphate metabolism" EXACT []
is_a: GO:0019692 ! deoxyribose phosphate metabolic process

[Term]
id: GO:0046390
name: ribose phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai]
subset: gosubset_prok
synonym: "ribose phosphate anabolism" EXACT []
synonym: "ribose phosphate biosynthesis" EXACT []
synonym: "ribose phosphate formation" EXACT []
synonym: "ribose phosphate synthesis" EXACT []
is_a: GO:0019302 ! D-ribose biosynthetic process
is_a: GO:0019693 ! ribose phosphate metabolic process

[Term]
id: GO:0046391
name: 5-phosphoribose 1-diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate." [GOC:ai]
subset: gosubset_prok
synonym: "5-phosphoribose 1-diphosphate metabolism" EXACT []
synonym: "PRPP metabolic process" EXACT []
xref: MetaCyc:PRPP-PWY
is_a: GO:0019693 ! ribose phosphate metabolic process

[Term]
id: GO:0046392
name: galactarate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactarate, the anion of galactaric acid." [GOC:ai]
subset: gosubset_prok
synonym: "galactarate breakdown" EXACT []
synonym: "galactarate catabolism" EXACT []
synonym: "galactarate degradation" EXACT []
is_a: GO:0019579 ! aldaric acid catabolic process
is_a: GO:0019580 ! galactarate metabolic process

[Term]
id: GO:0046393
name: D-galactarate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-galactarate, the D-enantiomer of galactarate, the anion of galactaric acid." [GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-galactarate metabolism" EXACT []
is_a: GO:0019580 ! galactarate metabolic process

[Term]
id: GO:0046394
name: carboxylic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "carboxylic acid anabolism" EXACT []
synonym: "carboxylic acid biosynthesis" EXACT []
synonym: "carboxylic acid formation" EXACT []
synonym: "carboxylic acid synthesis" EXACT []
is_a: GO:0016053 ! organic acid biosynthetic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046395
name: carboxylic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "carboxylic acid breakdown" EXACT []
synonym: "carboxylic acid catabolism" EXACT []
synonym: "carboxylic acid degradation" EXACT []
is_a: GO:0016054 ! organic acid catabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046396
name: D-galacturonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid. D-galacturonic acid is a component of plant gums and bacterial cell walls." [GOC:ai, GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-galacturonate metabolism" EXACT []
is_a: GO:0019586 ! galacturonate metabolic process

[Term]
id: GO:0046397
name: galacturonate catabolic process
namespace: biological_process
alt_id: GO:0019587
def: "The chemical reactions and pathways resulting in the breakdown of galacturonate, the anion of galacturonic acid." [GOC:ai]
subset: gosubset_prok
synonym: "galacturonate breakdown" EXACT []
synonym: "galacturonate catabolism" EXACT []
synonym: "galacturonate degradation" EXACT []
is_a: GO:0019586 ! galacturonate metabolic process
is_a: GO:0046365 ! monosaccharide catabolic process
is_a: GO:0046395 ! carboxylic acid catabolic process

[Term]
id: GO:0046398
name: UDP-glucuronate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "UDP-glucuronate metabolism" EXACT []
is_a: GO:0019585 ! glucuronate metabolic process

[Term]
id: GO:0046399
name: glucuronate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucuronate, the anion of glucuronic acid." [GOC:ai]
subset: gosubset_prok
synonym: "glucuronate anabolism" EXACT []
synonym: "glucuronate biosynthesis" EXACT []
synonym: "glucuronate formation" EXACT []
synonym: "glucuronate synthesis" EXACT []
is_a: GO:0016051 ! carbohydrate biosynthetic process
is_a: GO:0019585 ! glucuronate metabolic process
is_a: GO:0046394 ! carboxylic acid biosynthetic process

[Term]
id: GO:0046400
name: keto-3-deoxy-D-manno-octulosonic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria." [ChEBI:32817, GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "KDO metabolic process" EXACT [GOC:mah]
synonym: "KDO metabolism" EXACT [GOC:mah]
synonym: "keto-3-deoxy-D-manno-octulosonic acid metabolism" EXACT []
synonym: "ketodeoxyoctanoate metabolic process" RELATED [ISBN:0198506732]
is_a: GO:0005996 ! monosaccharide metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046401
name: lipopolysaccharide core region metabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. The structure of this core oligosaccharide appears to be similar in closely related bacterial strains." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "lipopolysaccharide core region metabolism" EXACT []
synonym: "LPS core region metabolic process" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
relationship: part_of GO:0008653 ! lipopolysaccharide metabolic process

[Term]
id: GO:0046402
name: O antigen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "O antigen metabolism" EXACT []
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0046403
name: polynucleotide 3'-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage." [EC:3.1.3.32]
comment: Consider also annotating to the molecular function term 'damaged DNA binding ; GO:0003684'.
synonym: "2'(3')-polynucleotidase activity" EXACT [EC:3.1.3.32]
synonym: "5'-polynucleotidekinase 3'-phosphatase activity" EXACT [EC:3.1.3.32]
synonym: "deoxyribonucleate 3'-phosphatase activity" EXACT [EC:3.1.3.32]
synonym: "DNA 3'-phosphatase activity" EXACT [EC:3.1.3.32]
synonym: "polynucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.32]
xref: EC:3.1.3.32
xref: MetaCyc:POLYNUCLEOTIDE-3-PHOSPHATASE-RXN
is_a: GO:0019204 ! nucleotide phosphatase activity

[Term]
id: GO:0046404
name: ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA." [EC:2.7.1.78]
synonym: "ATP-dependent DNA 5'-hydroxyl-kinase activity" EXACT []
synonym: "ATP-dependent DNA kinase activity" EXACT []
synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD []
synonym: "ATP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity" EXACT []
xref: EC:2.7.1.78
xref: MetaCyc:POLYNUCLEOTIDE-5-HYDROXYL-KINASE-RXN
is_a: GO:0051733 ! polydeoxyribonucleotide kinase activity
is_a: GO:0051734 ! ATP-dependent polynucleotide kinase activity

[Term]
id: GO:0046405
name: glycerol dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O." [EC:4.2.1.30, PMID:18307109]
subset: gosubset_prok
synonym: "glycerol dehydrase activity" EXACT [EC:4.2.1.30]
synonym: "glycerol hydro-lyase (3-hydroxypropanal-forming)" EXACT [EC:4.2.1.30]
synonym: "glycerol hydro-lyase activity" EXACT [EC:4.2.1.30]
xref: EC:4.2.1.30
xref: MetaCyc:GLYCEROL-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity
is_a: GO:0070283 ! radical SAM enzyme activity

[Term]
id: GO:0046406
name: magnesium protoporphyrin IX methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + magnesium protoporphyrin = S-adenosyl-L-homocysteine + magnesium protoporphyrin monomethyl ester." [EC:2.1.1.11]
subset: gosubset_prok
synonym: "(-)-S-adenosyl-L-methionine:magnesium-protoporphyrin IX methyltransferase activity" EXACT [EC:2.1.1.11]
synonym: "magnesium-protoporphyrin O-methyltransferase activity" EXACT []
synonym: "Mg-protoporphyrin IX methyltransferase activity" EXACT [EC:2.1.1.11]
synonym: "S-adenosyl-L-methionine:magnesium-protoporphyrin O-methyltransferase activity" EXACT [EC:2.1.1.11]
synonym: "S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase activity" EXACT [EC:2.1.1.11]
synonym: "S-adenosyl-L-methionine:Mg protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11]
synonym: "S-adenosylmethionine-magnesium protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11]
synonym: "S-adenosylmethioninemagnesium protoporphyrin methyltransferase activity" EXACT [EC:2.1.1.11]
xref: EC:2.1.1.11
xref: MetaCyc:RXN-MG-PROTOPORPHYRIN-METHYLESTER-SYN
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0046408
name: chlorophyll synthetase activity
namespace: molecular_function
def: "Catalysis of the esterification reaction: chlorophyllide a + phytyl pyrophosphate = chlorophyll a + pyrophosphate." [ISBN:0471331309 "Biochemical Pathways", PMID:8552034]
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0046409
name: p-coumarate 3-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the 3-hydroxylation reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H20 + NADP+." [PMID:11429408, PMID:11891223]
synonym: "cytochrome P450 CYP98A3" NARROW []
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0046410
name: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 2-oxoglutarate + isochorismate = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate + CO2." [EC:2.5.1.64, PMID:1459959]
comment: This term was made obsolete because it was derived from an EC entry (2.5.1.64) that has since been split into two entries.
is_obsolete: true
consider: GO:0070204
consider: GO:0070205

[Term]
id: GO:0046411
name: 2-keto-3-deoxygluconate transport
namespace: biological_process
def: "The directed movement of 2-keto-3-deoxygluconate into, out of, within or between cells by means of some external agent such as a transporter or pore by means of some external agent such as a transporter or pore." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0046412
name: phenylmercury acetate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group." [GOC:ai]
subset: gosubset_prok
synonym: "phenylmercury acetate metabolism" EXACT []
is_a: GO:0018941 ! organomercury metabolic process
is_a: GO:0042537 ! benzene and derivative metabolic process

[Term]
id: GO:0046413
name: organomercury catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organomercury compounds, any organic compound containing a mercury atom." [GOC:ai]
subset: gosubset_prok
synonym: "organomercury breakdown" EXACT []
synonym: "organomercury catabolism" EXACT []
synonym: "organomercury degradation" EXACT []
is_a: GO:0018941 ! organomercury metabolic process
is_a: GO:0044248 ! cellular catabolic process

[Term]
id: GO:0046414
name: organomercury biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of organomercury compounds, any organic compound containing a mercury atom." [GOC:ai]
subset: gosubset_prok
synonym: "organomercury anabolism" EXACT []
synonym: "organomercury biosynthesis" EXACT []
synonym: "organomercury formation" EXACT []
synonym: "organomercury synthesis" EXACT []
is_a: GO:0018941 ! organomercury metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0046415
name: urate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "urate metabolism" EXACT []
is_a: GO:0006082 ! organic acid metabolic process
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0046416
name: D-amino acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg]
subset: gosubset_prok
synonym: "D-amino acid metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0046417
name: chorismate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "chorismate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0046418
name: nopaline metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nopaline, (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." [GOC:ai]
subset: gosubset_prok
synonym: "nopaline metabolism" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process

[Term]
id: GO:0046419
name: octopine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving octopine, (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine." [GOC:ai]
subset: gosubset_prok
synonym: "octopine metabolism" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process

[Term]
id: GO:0046421
name: methylisocitrate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate." [EC:4.1.3.30]
subset: gosubset_prok
synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming)" EXACT [EC:4.1.3.30]
synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase activity" EXACT [EC:4.1.3.30]
synonym: "2-methylisocitrate lyase activity" EXACT []
synonym: "MICL" RELATED [EC:4.1.3.30]
xref: EC:4.1.3.30
xref: MetaCyc:METHYLISOCITRATE-LYASE-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0046422
name: violaxanthin de-epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; also antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O." [EC:1.10.99.3, GOC:ai, ISBN:0471331309 "Biochemical Pathways"]
synonym: "VDE" RELATED [EC:1.10.99.3]
synonym: "violaxanthin:ascorbate oxidoreductase activity" EXACT [EC:1.10.99.3]
xref: EC:1.10.99.3
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0046423
name: allene-oxide cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate." [EC:5.3.99.6]
synonym: "(9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing)" EXACT [EC:5.3.99.6]
xref: EC:5.3.99.6
xref: MetaCyc:ALLENE-OXIDE-CYCLASE-RXN
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0046424
name: ferulate 5-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+." [PMID:8692910, PMID:9880351]
xref: MetaCyc:RXN-1121
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH

[Term]
id: GO:0046425
name: regulation of JAK-STAT cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the JAK-STAT signaling pathway." [GOC:bf]
is_a: GO:0010627 ! regulation of protein kinase cascade
relationship: regulates GO:0007259 ! JAK-STAT cascade

[Term]
id: GO:0046426
name: negative regulation of JAK-STAT cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
synonym: "down regulation of JAK-STAT cascade" EXACT []
synonym: "down-regulation of JAK-STAT cascade" EXACT []
synonym: "downregulation of JAK-STAT cascade" EXACT []
synonym: "inhibition of JAK-STAT cascade" NARROW []
is_a: GO:0010741 ! negative regulation of protein kinase cascade
is_a: GO:0046425 ! regulation of JAK-STAT cascade
relationship: negatively_regulates GO:0007259 ! JAK-STAT cascade

[Term]
id: GO:0046427
name: positive regulation of JAK-STAT cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf]
synonym: "activation of JAK-STAT cascade" NARROW []
synonym: "stimulation of JAK-STAT cascade" NARROW []
synonym: "up regulation of JAK-STAT cascade" EXACT []
synonym: "up-regulation of JAK-STAT cascade" EXACT []
synonym: "upregulation of JAK-STAT cascade" EXACT []
is_a: GO:0010740 ! positive regulation of protein kinase cascade
is_a: GO:0046425 ! regulation of JAK-STAT cascade
relationship: positively_regulates GO:0007259 ! JAK-STAT cascade

[Term]
id: GO:0046428
name: 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophosphate = dimethylmenaquinone + pyrophosphate + CO2." [MetaCyc:DMK-RXN]
synonym: "1,4-Dihydroxy-2-naphtoate prenyltransferase activity" EXACT []
xref: EC:2.5.1.-
xref: MetaCyc:DMK-RXN
is_a: GO:0002094 ! polyprenyltransferase activity

[Term]
id: GO:0046429
name: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative way of naming 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate." [EC:1.17.4.3, PMID:11752431]
subset: gosubset_prok
synonym: "(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating)" EXACT [EC:1.17.4.3]
synonym: "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase activity" EXACT []
synonym: "1-hydroxy-2-methyl-2-butenyl 4-diphosphate synthase activity" EXACT [EC:1.17.4.3]
xref: EC:1.17.4.3
is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor

[Term]
id: GO:0046430
name: non-phosphorylated glucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving non-phosphorylated forms of glucose." [GOC:ai]
subset: gosubset_prok
synonym: "non-phosphorylated glucose metabolism" EXACT []
is_a: GO:0006006 ! glucose metabolic process

[Term]
id: GO:0046431
name: (R)-4-hydroxymandelate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving (R)-4-hydroxymandelate, the anion of a hydroxylated derivative of mandelate (alpha-hydroxybenzeneacetate)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "(R)-4-hydroxymandelate metabolism" EXACT []
is_a: GO:0018924 ! mandelate metabolic process
is_a: GO:0018958 ! phenol metabolic process

[Term]
id: GO:0046432
name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai]
subset: gosubset_prok
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process

[Term]
id: GO:0046433
name: 2-aminoethylphosphonate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2-aminoethylphosphonate, most abundant and ubiquitous of naturally occurring phosphonates. It is typically found as a conjugate of glycans, lipids, and proteins, which in turn perform essential biochemical functions in specialized lower organisms." [GOC:ai, PMID:12107130]
subset: gosubset_prok
synonym: "2-aminoethylphosphonate metabolism" EXACT []
synonym: "2-phosphonoethylamine metabolic process" EXACT []
synonym: "2-phosphonoethylamine metabolism" EXACT []
synonym: "ciliatine metabolic process" EXACT []
synonym: "ciliatine metabolism" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0019634 ! phosphonate metabolic process
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:0046434
name: organophosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai]
subset: gosubset_prok
synonym: "organophosphate breakdown" EXACT []
synonym: "organophosphate catabolism" EXACT []
synonym: "organophosphate degradation" EXACT []
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:0046435
name: 3-(3-hydroxy)phenylpropionate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate." [GOC:ai]
subset: gosubset_prok
synonym: "3-(3-hydroxy)phenylpropionate metabolism" EXACT []
is_a: GO:0018962 ! 3-phenylpropionate metabolic process

[Term]
id: GO:0046436
name: D-alanine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-alanine, the D-enantiomer of the amino acid alanine, i.e. (2R)-2-aminopropanoic acid." [ChEBI:15570, GOC:ai, GOC:jsg]
subset: gosubset_prok
synonym: "D-alanine metabolism" EXACT []
is_a: GO:0046144 ! D-alanine family amino acid metabolic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0046437
name: D-amino acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg]
subset: gosubset_prok
synonym: "D-amino acid anabolism" EXACT []
synonym: "D-amino acid biosynthesis" EXACT []
synonym: "D-amino acid formation" EXACT []
synonym: "D-amino acid synthesis" EXACT []
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0046416 ! D-amino acid metabolic process

[Term]
id: GO:0046438
name: D-cysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin." [GOC:ai]
subset: gosubset_prok
synonym: "D-cysteine metabolism" EXACT []
is_a: GO:0006534 ! cysteine metabolic process

[Term]
id: GO:0046439
name: L-cysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid." [ChEBI:17561, GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-cysteine metabolism" EXACT []
is_a: GO:0006534 ! cysteine metabolic process

[Term]
id: GO:0046440
name: L-lysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid, i.e. (2S)-2,6-diaminohexanoic acid." [ChEBI:18019, GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-lysine metabolism" EXACT []
is_a: GO:0006553 ! lysine metabolic process

[Term]
id: GO:0046441
name: D-lysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid." [ChEBI:16855, GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-lysine metabolism" EXACT []
is_a: GO:0006553 ! lysine metabolic process

[Term]
id: GO:0046442
name: aerobactin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai]
subset: gosubset_prok
synonym: "aerobactin metabolism" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process

[Term]
id: GO:0046443
name: FAD metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "FAD metabolism" EXACT []
synonym: "flavin adenine dinucleotide metabolic process" EXACT []
synonym: "flavin adenine dinucleotide metabolism" EXACT []
synonym: "flavin-adenine dinucleotide metabolic process" EXACT []
synonym: "flavin-adenine dinucleotide metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0042726 ! riboflavin and derivative metabolic process

[Term]
id: GO:0046444
name: FMN metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:ai, http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "FMN metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process
is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process
is_a: GO:0042726 ! riboflavin and derivative metabolic process

[Term]
id: GO:0046445
name: benzyl isoquinoline alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "benzyl isoquinoline alkaloid metabolism" EXACT []
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process

[Term]
id: GO:0046446
name: purine alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure." [GOC:ai]
subset: gosubset_prok
synonym: "purine alkaloid metabolism" EXACT []
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0046447
name: terpenoid indole alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate)." [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html]
subset: gosubset_prok
synonym: "terpenoid indole alkaloid metabolism" EXACT []
is_a: GO:0009820 ! alkaloid metabolic process

[Term]
id: GO:0046448
name: tropane alkaloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "tropane alkaloid metabolism" EXACT []
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0046449
name: creatinine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "creatinine metabolism" EXACT []
is_a: GO:0006599 ! phosphagen metabolic process
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0042180 ! cellular ketone metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0046450
name: dethiobiotin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dethiobiotin, a derivative of biotin formed by replacing the sulfur atom by two hydrogen atoms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "desthiobiotin metabolic process" EXACT []
synonym: "desthiobiotin metabolism" EXACT []
synonym: "dethiobiotin metabolism" EXACT []
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0046451
name: diaminopimelate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diaminopimelate, the anion of the dicarboxylic acid 2,6-diaminoheptanedioic acid. It is an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "diaminopimelate metabolism" EXACT []
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0046452
name: dihydrofolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dihydrofolate metabolism" EXACT []
synonym: "dihydrofolate reduction" NARROW []
is_a: GO:0006760 ! folic acid and derivative metabolic process
is_a: GO:0042558 ! pteridine and derivative metabolic process

[Term]
id: GO:0046453
name: dipyrrin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group." [http://www.chem.qmw.ac.uk/iupac/class/tetpy.html#03]
subset: gosubset_prok
synonym: "dipyrrin metabolism" EXACT []
is_a: GO:0009820 ! alkaloid metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0046454
name: dimethylsilanediol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products." [GOC:ai]
subset: gosubset_prok
synonym: "dimethylsilanediol metabolism" EXACT []
is_a: GO:0018945 ! organosilicon metabolic process
is_a: GO:0034311 ! diol metabolic process

[Term]
id: GO:0046455
name: organosilicon catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of organosilicons, any organic compound that contains silicon." [GOC:ai]
subset: gosubset_prok
synonym: "organosilicon breakdown" EXACT []
synonym: "organosilicon catabolism" EXACT []
synonym: "organosilicon degradation" EXACT []
synonym: "organosilicone catabolic process" EXACT []
synonym: "organosilicone catabolism" EXACT []
is_a: GO:0018945 ! organosilicon metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0046456
name: icosanoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "eicosanoid biosynthesis" EXACT []
synonym: "eicosanoid biosynthetic process" EXACT []
synonym: "icosanoid anabolism" EXACT []
synonym: "icosanoid biosynthesis" EXACT []
synonym: "icosanoid formation" EXACT []
synonym: "icosanoid synthesis" EXACT []
xref: Wikipedia:Eicosanoid
is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process
is_a: GO:0006690 ! icosanoid metabolic process

[Term]
id: GO:0046457
name: prostanoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure." [GOC:ai]
subset: gosubset_prok
synonym: "prostanoid anabolism" EXACT []
synonym: "prostanoid biosynthesis" EXACT []
synonym: "prostanoid formation" EXACT []
synonym: "prostanoid synthesis" EXACT []
xref: Reactome:209962 "Prostanoid hormones"
xref: Reactome:448812 "Prostanoid hormones"
xref: Reactome:469928 "Prostanoid hormones"
xref: Reactome:487631 "Prostanoid hormones"
xref: Reactome:507590 "Prostanoid hormones"
xref: Reactome:517778 "Prostanoid hormones"
xref: Reactome:526658 "Prostanoid hormones"
xref: Reactome:531410 "Prostanoid hormones"
xref: Reactome:536827 "Prostanoid hormones"
xref: Reactome:542462 "Prostanoid hormones"
xref: Reactome:547866 "Prostanoid hormones"
xref: Reactome:552478 "Prostanoid hormones"
xref: Reactome:558095 "Prostanoid hormones"
xref: Reactome:568620 "Prostanoid hormones"
xref: Reactome:581824 "Prostanoid hormones"
xref: Reactome:585978 "Prostanoid hormones"
xref: Reactome:592730 "Prostanoid hormones"
xref: Reactome:595576 "Prostanoid hormones"
xref: Reactome:597411 "Prostanoid hormones"
xref: Reactome:602621 "Prostanoid hormones"
xref: Wikipedia:Prostanoid#Biosynthesis
is_a: GO:0006692 ! prostanoid metabolic process
is_a: GO:0046456 ! icosanoid biosynthetic process

[Term]
id: GO:0046458
name: hexadecanal metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hexadecanal, the C16 straight chain aldehyde." [http://chemfinder.cambridgesoft.com/]
subset: gosubset_prok
synonym: "hexadecanal metabolism" EXACT []
is_a: GO:0006081 ! cellular aldehyde metabolic process

[Term]
id: GO:0046459
name: short-chain fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fatty acids with a chain length of less than 8 carbons." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "short-chain fatty acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0046460
name: neutral lipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity." [GOC:ai]
subset: gosubset_prok
synonym: "neutral lipid anabolism" EXACT []
synonym: "neutral lipid biosynthesis" EXACT []
synonym: "neutral lipid formation" EXACT []
synonym: "neutral lipid synthesis" EXACT []
is_a: GO:0006638 ! neutral lipid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0046461
name: neutral lipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity." [GOC:ai]
subset: gosubset_prok
synonym: "neutral lipid breakdown" EXACT []
synonym: "neutral lipid catabolism" EXACT []
synonym: "neutral lipid degradation" EXACT []
is_a: GO:0006638 ! neutral lipid metabolic process
is_a: GO:0044242 ! cellular lipid catabolic process

[Term]
id: GO:0046462
name: monoacylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "monoacylglycerol metabolism" EXACT []
synonym: "monoglyceride metabolic process" EXACT []
synonym: "monoglyceride metabolism" EXACT []
is_a: GO:0006639 ! acylglycerol metabolic process

[Term]
id: GO:0046463
name: acylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai]
subset: gosubset_prok
synonym: "acylglycerol anabolism" EXACT []
synonym: "acylglycerol biosynthesis" EXACT []
synonym: "acylglycerol formation" EXACT []
synonym: "acylglycerol synthesis" EXACT []
is_a: GO:0006639 ! acylglycerol metabolic process
is_a: GO:0045017 ! glycerolipid biosynthetic process
is_a: GO:0046460 ! neutral lipid biosynthetic process
is_a: GO:0046504 ! glycerol ether biosynthetic process

[Term]
id: GO:0046464
name: acylglycerol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai]
subset: gosubset_prok
synonym: "acylglycerol breakdown" EXACT []
synonym: "acylglycerol catabolism" EXACT []
synonym: "acylglycerol degradation" EXACT []
is_a: GO:0006639 ! acylglycerol metabolic process
is_a: GO:0044269 ! glycerol ether catabolic process
is_a: GO:0046461 ! neutral lipid catabolic process
is_a: GO:0046503 ! glycerolipid catabolic process

[Term]
id: GO:0046465
name: dolichyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dolichyl diphosphate, a diphosphorylated dolichol derivative. In eukaryotes, these function as carriers of mono- and oligosaccharide residues in the glycosylation of lipids and proteins within intracellular membranes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "dolichyl diphosphate metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0019348 ! dolichol metabolic process

[Term]
id: GO:0046466
name: membrane lipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai]
subset: gosubset_prok
synonym: "membrane lipid breakdown" EXACT []
synonym: "membrane lipid catabolism" EXACT []
synonym: "membrane lipid degradation" EXACT []
is_a: GO:0006643 ! membrane lipid metabolic process
is_a: GO:0044242 ! cellular lipid catabolic process

[Term]
id: GO:0046467
name: membrane lipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai]
subset: gosubset_prok
synonym: "membrane lipid anabolism" EXACT []
synonym: "membrane lipid biosynthesis" EXACT []
synonym: "membrane lipid formation" EXACT []
synonym: "membrane lipid synthesis" EXACT []
is_a: GO:0006643 ! membrane lipid metabolic process
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0046468
name: phosphatidyl-N-monomethylethanolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group. Present in trace levels in plants and slightly higher in bacteria." [http://www.lipid.co.uk]
subset: gosubset_prok
synonym: "phosphatidyl-N-monomethylethanolamine metabolism" EXACT []
synonym: "PMME metabolic process" EXACT []
synonym: "PMME metabolism" EXACT []
is_a: GO:0046337 ! phosphatidylethanolamine metabolic process

[Term]
id: GO:0046469
name: platelet activating factor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli." [ISBN:0198547684]
synonym: "PAF metabolic process" EXACT []
synonym: "PAF metabolism" EXACT []
synonym: "platelet activating factor metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0042439 ! ethanolamine and derivative metabolic process

[Term]
id: GO:0046470
name: phosphatidylcholine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphatidylcholine metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0042439 ! ethanolamine and derivative metabolic process

[Term]
id: GO:0046471
name: phosphatidylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphatidylglycerol metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process

[Term]
id: GO:0046473
name: phosphatidic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphatidic acid metabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046474
name: glycerophospholipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycerophospholipid anabolism" EXACT []
synonym: "glycerophospholipid biosynthesis" EXACT []
synonym: "glycerophospholipid formation" EXACT []
synonym: "glycerophospholipid synthesis" EXACT []
synonym: "phosphoglyceride biosynthesis" EXACT []
synonym: "phosphoglyceride biosynthetic process" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0045017 ! glycerolipid biosynthetic process

[Term]
id: GO:0046475
name: glycerophospholipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycerophospholipid breakdown" EXACT []
synonym: "glycerophospholipid catabolism" EXACT []
synonym: "glycerophospholipid degradation" EXACT []
synonym: "phosphoglyceride catabolic process" EXACT []
synonym: "phosphoglyceride catabolism" EXACT []
is_a: GO:0006650 ! glycerophospholipid metabolic process
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0046503 ! glycerolipid catabolic process

[Term]
id: GO:0046476
name: glycosylceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai]
subset: gosubset_prok
synonym: "glycosylceramide anabolism" EXACT []
synonym: "glycosylceramide biosynthesis" EXACT []
synonym: "glycosylceramide formation" EXACT []
synonym: "glycosylceramide synthesis" EXACT []
is_a: GO:0006677 ! glycosylceramide metabolic process
is_a: GO:0009247 ! glycolipid biosynthetic process
is_a: GO:0046513 ! ceramide biosynthetic process

[Term]
id: GO:0046477
name: glycosylceramide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai]
subset: gosubset_prok
synonym: "glycosylceramide breakdown" EXACT []
synonym: "glycosylceramide catabolism" EXACT []
synonym: "glycosylceramide degradation" EXACT []
is_a: GO:0006677 ! glycosylceramide metabolic process
is_a: GO:0019377 ! glycolipid catabolic process
is_a: GO:0046514 ! ceramide catabolic process

[Term]
id: GO:0046478
name: lactosylceramide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lactosylceramides, Gal beta(1,4)Glc beta(1,1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "lactosylceramide metabolism" EXACT []
is_a: GO:0006677 ! glycosylceramide metabolic process
is_a: GO:0006687 ! glycosphingolipid metabolic process

[Term]
id: GO:0046479
name: glycosphingolipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glycosphingolipid breakdown" EXACT []
synonym: "glycosphingolipid catabolism" EXACT []
synonym: "glycosphingolipid degradation" EXACT []
is_a: GO:0006687 ! glycosphingolipid metabolic process
is_a: GO:0019377 ! glycolipid catabolic process
is_a: GO:0030149 ! sphingolipid catabolic process

[Term]
id: GO:0046480
name: galactolipid galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol." [EC:2.4.1.184]
synonym: "3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol:mono-3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.184]
synonym: "DGDG synthase activity" BROAD [EC:2.4.1.184]
synonym: "digalactosyldiacylglycerol synthase activity" BROAD [EC:2.4.1.184]
synonym: "galactolipid-galactolipid galactosyltransferase activity" EXACT [EC:2.4.1.184]
synonym: "galactolipid:galactolipid galactosyltransferase activity" EXACT []
synonym: "GGGT activity" EXACT [EC:2.4.1.184]
synonym: "interlipid galactosyltransferase activity" RELATED [EC:2.4.1.184]
xref: EC:2.4.1.184
xref: MetaCyc:RXN-1226
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0046481
name: digalactosyldiacylglycerol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + 3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol = UDP + 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn-glycerol." [EC:2.4.1.241, MetaCyc:RXN-1225]
synonym: "DGD1" NARROW []
synonym: "DGD2" NARROW []
synonym: "DGDG synthase activity" BROAD [EC:2.4.1.241]
synonym: "UDP-galactose-dependent DGDG synthase activity" EXACT [EC:2.4.1.241]
synonym: "UDP-galactose-dependent digalactosyldiacylglycerol synthase activity" EXACT [EC:2.4.1.241]
synonym: "UDP-galactose:3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol 6-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.241]
synonym: "UDP-galactose:MGDG galactosyltransferase activity" EXACT []
xref: EC:2.4.1.241
xref: MetaCyc:RXN-1225
xref: Wikipedia:Digalactosyldiacylglycerol_synthase
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0046482
name: para-aminobenzoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11377864, PMID:11960743]
subset: gosubset_prok
synonym: "4-aminobenzoic acid metabolic process" EXACT []
synonym: "4-aminobenzoic acid metabolism" EXACT []
synonym: "p-aminobenzoic acid metabolic process" EXACT []
synonym: "p-aminobenzoic acid metabolism" EXACT []
synonym: "PABA metabolic process" EXACT []
synonym: "PABA metabolism" EXACT []
synonym: "para-aminobenzoic acid metabolism" EXACT []
synonym: "vitamin Bx metabolic process" EXACT []
synonym: "vitamin Bx metabolism" EXACT []
is_a: GO:0006760 ! folic acid and derivative metabolic process
is_a: GO:0009072 ! aromatic amino acid family metabolic process
relationship: part_of GO:0046655 ! folic acid metabolic process

[Term]
id: GO:0046483
name: heterocycle metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "heterocycle metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0046484
name: oxazole or thiazole metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "oxazole or thiazole metabolism" EXACT []
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0046485
name: ether lipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:15337120]
subset: gosubset_prok
synonym: "ether lipid metabolism" EXACT []
synonym: "plasmalogen metabolic process" NARROW []
xref: Wikipedia:Ether_lipid
is_a: GO:0006662 ! glycerol ether metabolic process
is_a: GO:0046486 ! glycerolipid metabolic process

[Term]
id: GO:0046486
name: glycerolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis." [GOC:ai, PMID:8906569]
subset: gosubset_prok
synonym: "glycerolipid metabolism" EXACT []
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0046487
name: glyoxylate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "glyoxylate metabolism" EXACT []
xref: Reactome:389661 "Glyoxylate metabolism"
xref: Reactome:449131 "Glyoxylate metabolism"
xref: Reactome:470244 "Glyoxylate metabolism"
xref: Reactome:487925 "Glyoxylate metabolism"
xref: Reactome:507896 "Glyoxylate metabolism"
xref: Reactome:517788 "Glyoxylate metabolism"
xref: Reactome:526618 "Glyoxylate metabolism"
xref: Reactome:531418 "Glyoxylate metabolism"
xref: Reactome:536790 "Glyoxylate metabolism"
xref: Reactome:542546 "Glyoxylate metabolism"
xref: Reactome:547874 "Glyoxylate metabolism"
xref: Reactome:552447 "Glyoxylate metabolism"
xref: Reactome:558059 "Glyoxylate metabolism"
xref: Reactome:568705 "Glyoxylate metabolism"
xref: Reactome:581908 "Glyoxylate metabolism"
xref: Reactome:585946 "Glyoxylate metabolism"
xref: Reactome:592803 "Glyoxylate metabolism"
xref: Reactome:597414 "Glyoxylate metabolism"
xref: Reactome:598183 "Glyoxylate metabolism"
xref: Reactome:599757 "Glyoxylate metabolism"
xref: Reactome:600658 "Glyoxylate metabolism"
xref: Reactome:602567 "Glyoxylate metabolism"
is_a: GO:0006081 ! cellular aldehyde metabolic process
is_a: GO:0032787 ! monocarboxylic acid metabolic process

[Term]
id: GO:0046488
name: phosphatidylinositol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphatidylinositol metabolism" EXACT []
synonym: "PtdIns metabolic process" EXACT []
synonym: "PtdIns metabolism" EXACT []
is_a: GO:0030384 ! phosphoinositide metabolic process

[Term]
id: GO:0046489
name: phosphoinositide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phosphoinositides, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphoinositide anabolism" EXACT []
synonym: "phosphoinositide biosynthesis" EXACT []
synonym: "phosphoinositide formation" EXACT []
synonym: "phosphoinositide synthesis" EXACT []
is_a: GO:0030384 ! phosphoinositide metabolic process
is_a: GO:0046474 ! glycerophospholipid biosynthetic process

[Term]
id: GO:0046490
name: isopentenyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
synonym: "IPP metabolic process" EXACT []
synonym: "IPP metabolism" EXACT []
synonym: "isopentenyl diphosphate metabolism" EXACT []
synonym: "isopentenyl pyrophosphate metabolic process" EXACT []
synonym: "isopentenyl pyrophosphate metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process

[Term]
id: GO:0046491
name: L-methylmalonyl-CoA metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA. S-methylmalonyl-CoA is an intermediate in the beta oxidation of odd-numbered fatty acids in animals." [GOC:jsg, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "L-methylmalonyl-CoA metabolism" EXACT []
is_a: GO:0006732 ! coenzyme metabolic process

[Term]
id: GO:0046492
name: heme b metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [http://www.chem.qmul.ac.uk/iupac/bioinorg/PR.html#25]
subset: gosubset_prok
synonym: "haem b metabolic process" EXACT []
synonym: "haem b metabolism" EXACT []
synonym: "heme b metabolism" EXACT []
is_a: GO:0042168 ! heme metabolic process

[Term]
id: GO:0046493
name: lipid A metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "lipid A metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0006664 ! glycolipid metabolic process

[Term]
id: GO:0046494
name: rhizobactin 1021 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [MetaCyc:PWY-761, PMID:11274118]
subset: gosubset_prok
synonym: "rhizobactin 1021 metabolism" EXACT []
is_a: GO:0009237 ! siderophore metabolic process

[Term]
id: GO:0046495
name: nicotinamide riboside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ChEBI:15927, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "N-ribosylnicotinamide metabolic process" EXACT [ChEBI:15927]
synonym: "nicotinamide riboside metabolism" EXACT []
is_a: GO:0070637 ! pyridine nucleoside metabolic process

[Term]
id: GO:0046496
name: nicotinamide nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "nicotinamide nucleotide metabolism" EXACT []
is_a: GO:0019362 ! pyridine nucleotide metabolic process

[Term]
id: GO:0046497
name: nicotinate nucleotide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid, or niacin)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "nicotinate nucleotide metabolism" EXACT []
is_a: GO:0019362 ! pyridine nucleotide metabolic process

[Term]
id: GO:0046498
name: S-adenosylhomocysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "S-adenosylhomocysteine metabolism" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process

[Term]
id: GO:0046499
name: S-adenosylmethioninamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE]
subset: gosubset_prok
synonym: "S-adenosylmethioninamine metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0009308 ! amine metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046500
name: S-adenosylmethionine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "S-adenosyl methionine metabolic process" EXACT []
synonym: "S-adenosyl methionine metabolism" EXACT []
synonym: "S-adenosylmethionine metabolism" EXACT []
synonym: "SAM metabolic process" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0046128 ! purine ribonucleoside metabolic process

[Term]
id: GO:0046501
name: protoporphyrinogen IX metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
comment: See also the molecular function term 'ferrochelatase activity ; GO:0004325'.
subset: gosubset_prok
synonym: "protoporphyrinogen IX metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006778 ! porphyrin metabolic process

[Term]
id: GO:0046502
name: uroporphyrinogen III metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving uroporphyrinogen III, a precursor for synthesis of vitamin B12, chlorophyll, and heme in organisms that produce these compounds." [GOC:ai]
subset: gosubset_prok
synonym: "uroporphyrinogen III metabolism" EXACT []
is_a: GO:0006725 ! cellular aromatic compound metabolic process
is_a: GO:0006778 ! porphyrin metabolic process
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046503
name: glycerolipid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]
subset: gosubset_prok
synonym: "glycerolipid breakdown" EXACT []
synonym: "glycerolipid catabolism" EXACT []
synonym: "glycerolipid degradation" EXACT []
is_a: GO:0044242 ! cellular lipid catabolic process
is_a: GO:0046486 ! glycerolipid metabolic process

[Term]
id: GO:0046504
name: glycerol ether biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai]
subset: gosubset_prok
synonym: "glycerol ether anabolism" EXACT []
synonym: "glycerol ether biosynthesis" EXACT []
synonym: "glycerol ether formation" EXACT []
synonym: "glycerol ether synthesis" EXACT []
is_a: GO:0006662 ! glycerol ether metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0046505
name: sulfolipid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sulfolipids, any compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid." [PMID:9751667]
subset: gosubset_prok
synonym: "sulfolipid metabolism" EXACT []
synonym: "sulpholipid metabolic process" EXACT []
synonym: "sulpholipid metabolism" EXACT []
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0044255 ! cellular lipid metabolic process

[Term]
id: GO:0046506
name: sulfolipid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sulfolipid, a compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid." [PMID:9751667]
subset: gosubset_prok
synonym: "sulfolipid anabolism" EXACT []
synonym: "sulfolipid biosynthesis" EXACT []
synonym: "sulfolipid formation" EXACT []
synonym: "sulfolipid synthesis" EXACT []
synonym: "sulpholipid biosynthesis" EXACT []
synonym: "sulpholipid biosynthetic process" EXACT []
xref: AraCyc:PWYQT-4427
is_a: GO:0008610 ! lipid biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0046505 ! sulfolipid metabolic process

[Term]
id: GO:0046507
name: UDPsulfoquinovose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + SO3(2-) (sulfite) = UDP-6-sulfoquinovose + H2O." [EC:3.13.1.1]
synonym: "sulfite:UDP-glucose sulfotransferase activity" EXACT []
synonym: "UDP-6-sulfo-6-deoxyglucose sulfohydrolase activity" EXACT [EC:3.13.1.1]
synonym: "UDP-sulfoquinovose synthase activity" EXACT [EC:3.13.1.1]
synonym: "UDPsulphoquinovose synthase activity" EXACT []
xref: EC:3.13.1.1
xref: MetaCyc:RXN-1223
is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds

[Term]
id: GO:0046508
name: hydrolase activity, acting on carbon-sulfur bonds
namespace: molecular_function
def: "Catalysis of the hydrolysis of any carbon-sulfur bond, C-S." [GOC:jl]
subset: gosubset_prok
synonym: "hydrolase activity, acting on carbon-sulphur bonds" EXACT []
xref: EC:3.13
is_a: GO:0016787 ! hydrolase activity

[Term]
id: GO:0046509
name: 1,2-diacylglycerol 3-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + 1,2-diacylglycerol = UDP + 3-beta-D-galactosyl-1,2-diacylglycerol." [EC:2.4.1.46]
synonym: "1-beta-MGDG activity" EXACT [EC:2.4.1.46]
synonym: "1beta-MGDG" RELATED [EC:2.4.1.46]
synonym: "MGDG synthase activity" EXACT []
synonym: "monogalactosyldiacylglycerol synthase activity" EXACT []
synonym: "UDP galactose-1,2-diacylglycerol galactosyltransferase activity" EXACT []
synonym: "UDP-galactose-diacylglyceride galactosyltransferase activity" EXACT []
synonym: "UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.46]
synonym: "UDP-galactose:diacylglycerol galactosyltransferase activity" EXACT []
synonym: "UDPgalactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.46]
synonym: "uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase activity" EXACT []
xref: EC:2.4.1.46
xref: MetaCyc:2.4.1.46-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0046510
name: UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfoquinovosyldiacylglycerol + UDP." [MetaCyc:RXN-1224]
synonym: "sulfolipid synthase" BROAD []
synonym: "UDP-sulphoquinovose:DAG sulphoquinovosyltransferase activity" EXACT []
xref: MetaCyc:RXN-1224
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0046511
name: sphinganine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphinganine, D-erythro-2-amino-1,3-octadecanediol." [GOC:ai]
subset: gosubset_prok
synonym: "dihydrosphingosine biosynthesis" EXACT []
synonym: "dihydrosphingosine biosynthetic process" EXACT []
synonym: "sphinganine anabolism" EXACT []
synonym: "sphinganine biosynthesis" EXACT []
synonym: "sphinganine formation" EXACT []
synonym: "sphinganine synthesis" EXACT []
is_a: GO:0006667 ! sphinganine metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:0046520 ! sphingoid biosynthetic process

[Term]
id: GO:0046512
name: sphingosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sphingosine anabolism" EXACT []
synonym: "sphingosine biosynthesis" EXACT []
synonym: "sphingosine formation" EXACT []
synonym: "sphingosine synthesis" EXACT []
is_a: GO:0006670 ! sphingosine metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:0046520 ! sphingoid biosynthetic process

[Term]
id: GO:0046513
name: ceramide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai]
subset: gosubset_prok
synonym: "ceramide anabolism" EXACT []
synonym: "ceramide biosynthesis" EXACT []
synonym: "ceramide formation" EXACT []
synonym: "ceramide synthesis" EXACT []
is_a: GO:0006672 ! ceramide metabolic process
is_a: GO:0046520 ! sphingoid biosynthetic process

[Term]
id: GO:0046514
name: ceramide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai]
subset: gosubset_prok
synonym: "ceramide breakdown" EXACT []
synonym: "ceramide catabolism" EXACT []
synonym: "ceramide degradation" EXACT []
is_a: GO:0006672 ! ceramide metabolic process
is_a: GO:0046521 ! sphingoid catabolic process

[Term]
id: GO:0046516
name: hypusine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ai]
subset: gosubset_prok
synonym: "hypusine metabolism" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process

[Term]
id: GO:0046517
name: octamethylcyclotetrasiloxane catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom." [GOC:ai, http://chemfinder.cambridgesoft.com/]
subset: gosubset_prok
synonym: "octamethylcyclotetrasiloxane breakdown" EXACT []
synonym: "octamethylcyclotetrasiloxane catabolism" EXACT []
synonym: "octamethylcyclotetrasiloxane degradation" EXACT []
is_a: GO:0046455 ! organosilicon catabolic process
is_a: GO:0046518 ! octamethylcyclotetrasiloxane metabolic process

[Term]
id: GO:0046518
name: octamethylcyclotetrasiloxane metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom." [GOC:ai, http://chemfinder.cambridgesoft.com/]
subset: gosubset_prok
synonym: "octamethylcyclotetrasiloxane metabolism" EXACT []
is_a: GO:0018945 ! organosilicon metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0046519
name: sphingoid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sphingoid base metabolic process" EXACT []
synonym: "sphingoid base metabolism" EXACT []
synonym: "sphingoid metabolism" EXACT []
is_a: GO:0006665 ! sphingolipid metabolic process

[Term]
id: GO:0046520
name: sphingoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sphingoid anabolism" EXACT []
synonym: "sphingoid biosynthesis" EXACT []
synonym: "sphingoid formation" EXACT []
synonym: "sphingoid synthesis" EXACT []
is_a: GO:0030148 ! sphingolipid biosynthetic process
is_a: GO:0046519 ! sphingoid metabolic process

[Term]
id: GO:0046521
name: sphingoid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "sphingoid breakdown" EXACT []
synonym: "sphingoid catabolism" EXACT []
synonym: "sphingoid degradation" EXACT []
is_a: GO:0030149 ! sphingolipid catabolic process
is_a: GO:0046519 ! sphingoid metabolic process

[Term]
id: GO:0046522
name: S-methyl-5-thioribose kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + S5-methyl-5-thio-D-ribose = ADP + S5-methyl-5-thio-D-ribose 1-phosphate." [EC:2.7.1.100]
subset: gosubset_prok
synonym: "5-methylthioribose kinase (phosphorylating)" EXACT [EC:2.7.1.100]
synonym: "5-methylthioribose kinase activity" EXACT []
synonym: "ATP:S-methyl-5-thio-D-ribose 1-phosphotransferase activity" EXACT [EC:2.7.1.100]
synonym: "ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase activity" EXACT [EC:2.7.1.100]
synonym: "methylthioribose kinase activity" EXACT [EC:2.7.1.100]
synonym: "MTR kinase activity" EXACT [EC:2.7.1.100]
xref: EC:2.7.1.100
xref: MetaCyc:5-METHYLTHIORIBOSE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0046523
name: S-methyl-5-thioribose-1-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methylthio-5-deoxy-D-ribose 1-phosphate = 5-methylthio-5-deoxy-D-ribulose 1-phosphate." [EC:5.3.1.23]
subset: gosubset_prok
synonym: "1-phospho-5'-S-methylthioribose isomerase activity" EXACT [EC:5.3.1.23]
synonym: "1-PMTR isomerase activity" EXACT [EC:5.3.1.23]
synonym: "5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.23]
synonym: "5-methylthioribose-1-phosphate isomerase activity" EXACT []
synonym: "methylthioribose 1-phosphate isomerase activity" EXACT [EC:5.3.1.23]
synonym: "MTR-1-P isomerase activity" EXACT [EC:5.3.1.23]
synonym: "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23]
synonym: "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.23]
synonym: "S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23]
synonym: "S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.23]
xref: EC:5.3.1.23
xref: MetaCyc:5.3.1.23-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0046524
name: sucrose-phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate." [EC:2.4.1.14]
subset: gosubset_prok
synonym: "SPS" RELATED [EC:2.4.1.14]
synonym: "sucrose 6-phosphate synthase activity" EXACT [EC:2.4.1.14]
synonym: "sucrose phosphate synthetase activity" EXACT [EC:2.4.1.14]
synonym: "sucrose phosphate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.14]
synonym: "sucrosephosphate-UDP glucosyltransferase activity" EXACT [EC:2.4.1.14]
synonym: "UDP-glucose-fructose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14]
synonym: "UDP-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.14]
synonym: "UDPglucose-fructose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14]
synonym: "UDPglucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.14]
synonym: "uridine diphosphoglucose-fructose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.14]
xref: EC:2.4.1.14
xref: MetaCyc:SUCROSE-PHOSPHATE-SYNTHASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0046525
name: xylosylprotein 4-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.133]
synonym: "galactosyltransferase I activity" RELATED [EC:2.4.1.133]
synonym: "UDP-D-galactose:D-xylose galactosyltransferase activity" EXACT [EC:2.4.1.133]
synonym: "UDP-D-galactose:xylose galactosyltransferase activity" EXACT [EC:2.4.1.133]
synonym: "UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.133]
synonym: "UDP-galactose:xylose galactosyltransferase activity" EXACT []
synonym: "UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.133]
synonym: "uridine diphosphogalactose-xylose galactosyltransferase activity" EXACT [EC:2.4.1.133]
xref: EC:2.4.1.133
xref: MetaCyc:2.4.1.133-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0046526
name: D-xylulose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: xylitol + NAD+ = D-xylulose + NADH + H+." [EC:1.1.1.9]
subset: gosubset_prok
synonym: "xylitol dehydrogenase activity" EXACT [EC:1.1.1.9]
xref: EC:1.1.1.9
xref: MetaCyc:D-XYLULOSE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
is_a: GO:0031320 ! hexitol dehydrogenase activity

[Term]
id: GO:0046527
name: glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: EC:2.4.1.-
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0046528
name: imaginal disc fusion
namespace: biological_process
def: "The process following disc eversion whereby imaginal discs fuse with adjacent disc derivatives to form a continuous adult epidermis." [PMID:11494317]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007560 ! imaginal disc morphogenesis

[Term]
id: GO:0046529
name: imaginal disc fusion, thorax closure
namespace: biological_process
def: "The joining of the parts of the wing imaginal discs, giving rise to the adult thorax." [http://sdb.bio.purdue.edu/fly/gene/fos4.htm]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0046528 ! imaginal disc fusion

[Term]
id: GO:0046530
name: photoreceptor cell differentiation
namespace: biological_process
alt_id: GO:0007467
def: "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0046532
name: regulation of photoreceptor cell differentiation
namespace: biological_process
alt_id: GO:0045673
def: "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
synonym: "regulation of photoreceptor differentiation" EXACT []
is_a: GO:0045664 ! regulation of neuron differentiation
relationship: regulates GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0046533
name: negative regulation of photoreceptor cell differentiation
namespace: biological_process
alt_id: GO:0045674
def: "Any process that stops, prevents or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
synonym: "down regulation of photoreceptor cell differentiation" EXACT []
synonym: "down regulation of photoreceptor differentiation" EXACT []
synonym: "down-regulation of photoreceptor cell differentiation" EXACT []
synonym: "down-regulation of photoreceptor differentiation" EXACT []
synonym: "downregulation of photoreceptor cell differentiation" EXACT []
synonym: "downregulation of photoreceptor differentiation" EXACT []
synonym: "inhibition of photoreceptor cell differentiation" NARROW []
synonym: "inhibition of photoreceptor differentiation" NARROW []
synonym: "negative regulation of photoreceptor differentiation" EXACT []
is_a: GO:0045665 ! negative regulation of neuron differentiation
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0046534
name: positive regulation of photoreceptor cell differentiation
namespace: biological_process
alt_id: GO:0045675
def: "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators]
synonym: "activation of photoreceptor cell differentiation" NARROW []
synonym: "activation of photoreceptor differentiation" NARROW []
synonym: "positive regulation of photoreceptor differentiation" EXACT []
synonym: "stimulation of photoreceptor cell differentiation" NARROW []
synonym: "stimulation of photoreceptor differentiation" NARROW []
synonym: "up regulation of photoreceptor cell differentiation" EXACT []
synonym: "up regulation of photoreceptor differentiation" EXACT []
synonym: "up-regulation of photoreceptor cell differentiation" EXACT []
synonym: "up-regulation of photoreceptor differentiation" EXACT []
synonym: "upregulation of photoreceptor cell differentiation" EXACT []
synonym: "upregulation of photoreceptor differentiation" EXACT []
is_a: GO:0045666 ! positive regulation of neuron differentiation
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0046535
name: detection of chemical stimulus involved in sensory perception of umami taste
namespace: biological_process
def: "The series of events required for a bitter taste stimulus to be received and converted to a molecular signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates." [GOC:ai, PMID:11894099]
synonym: "perception of umami taste, detection of chemical stimulus" EXACT []
synonym: "perception of umami taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of umami taste" EXACT []
synonym: "sensory detection of umami taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of umami taste" EXACT []
synonym: "sensory transduction of umami taste" EXACT []
synonym: "umami taste detection" EXACT []
is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste
relationship: part_of GO:0050917 ! sensory perception of umami taste

[Term]
id: GO:0046536
name: dosage compensation complex
namespace: cellular_component
def: "A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes." [GOC:kmv, GOC:mah]
subset: goslim_pir
is_a: GO:0032991 ! macromolecular complex
is_a: GO:0044427 ! chromosomal part
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0000803 ! sex chromosome

[Term]
id: GO:0046537
name: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D glycerate without requiring the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.1]
subset: gosubset_prok
synonym: "PGAM-i" RELATED [EC:5.4.2.1]
is_a: GO:0004619 ! phosphoglycerate mutase activity

[Term]
id: GO:0046538
name: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; requires the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.1]
subset: gosubset_prok
synonym: "glycerate phosphomutase (diphosphoglycerate cofactor) activity" EXACT [EC:5.4.2.1]
synonym: "PGAM-d" RELATED [EC:5.4.2.1]
is_a: GO:0004619 ! phosphoglycerate mutase activity

[Term]
id: GO:0046539
name: histamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + Nt-methylhistamine." [EC:2.1.1.8]
synonym: "histamine 1-methyltransferase activity" EXACT [EC:2.1.1.8]
synonym: "histamine methyltransferase activity" EXACT [EC:2.1.1.8]
synonym: "histamine-methylating enzyme" RELATED [EC:2.1.1.8]
synonym: "imidazolemethyltransferase activity" EXACT [EC:2.1.1.8]
synonym: "S-adenosyl-L-methionine:histamine N-tele-methyltransferase activity" EXACT [EC:2.1.1.8]
synonym: "S-adenosylmethionine-histamine N-methyltransferase activity" EXACT [EC:2.1.1.8]
xref: EC:2.1.1.8
xref: MetaCyc:HISTAMINE-N-METHYLTRANSFERASE-RXN
is_a: GO:0008170 ! N-methyltransferase activity

[Term]
id: GO:0046540
name: U4/U6 x U5 tri-snRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins." [PMID:11867543]
synonym: "U4/U6 . U5 snRNP complex" EXACT []
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0046541
name: saliva secretion
namespace: biological_process
def: "The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin." [http://cancerweb.ncl.ac.uk/]
synonym: "salivation" EXACT []
xref: Wikipedia:Salivation
is_a: GO:0007589 ! body fluid secretion
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0046542
name: alpha-factor export
namespace: biological_process
def: "OBSOLETE. The directed movement of alpha-factor, one of the two yeast mating factors, out of a cell." [GOC:ai]
comment: This term was made obsolete because it is a gene product based term and it does not involve a unique process.
is_obsolete: true
consider: GO:0015833

[Term]
id: GO:0046543
name: development of secondary female sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion." [GOC:ai]
is_a: GO:0045136 ! development of secondary sexual characteristics
relationship: part_of GO:0046660 ! female sex differentiation

[Term]
id: GO:0046544
name: development of secondary male sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion." [GOC:ai]
is_a: GO:0045136 ! development of secondary sexual characteristics
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0046545
name: development of primary female sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion." [GOC:ai]
is_a: GO:0045137 ! development of primary sexual characteristics
relationship: part_of GO:0046660 ! female sex differentiation

[Term]
id: GO:0046546
name: development of primary male sexual characteristics
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion." [GOC:ai]
is_a: GO:0045137 ! development of primary sexual characteristics
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0046547
name: trans-aconitate 3-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate." [EC:2.1.1.145]
synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase activity" EXACT [EC:2.1.1.145]
xref: EC:2.1.1.145
xref: MetaCyc:2.1.1.145-RXN
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0046548
name: retinal rod cell development
namespace: biological_process
def: "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0042462 ! eye photoreceptor cell development

[Term]
id: GO:0046549
name: retinal cone cell development
namespace: biological_process
def: "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0042462 ! eye photoreceptor cell development
relationship: part_of GO:0042670 ! retinal cone cell differentiation

[Term]
id: GO:0046550
name: (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine biosynthetic process from asparagine
namespace: biological_process
def: "The modification of asparagine to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine as found in microcin C7 produced from the mccA gene in E. coli plasmid pMccC7." [RESID:AA0328]
subset: gosubset_prok
synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine anabolism from asparagine" EXACT []
synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine formation from asparagine" EXACT []
synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine synthesis from asparagine" EXACT []
xref: RESID:AA0328
is_a: GO:0006528 ! asparagine metabolic process
is_a: GO:0018196 ! peptidyl-asparagine modification

[Term]
id: GO:0046551
name: retinal cone cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell. A retinal cone cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:mtg_sensu, PMID:3076112, PMID:3937883]
is_a: GO:0060220 ! camera-type eye photoreceptor cell fate commitment
relationship: part_of GO:0042670 ! retinal cone cell differentiation

[Term]
id: GO:0046552
name: photoreceptor cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0046530 ! photoreceptor cell differentiation

[Term]
id: GO:0046553
name: D-malate dehydrogenase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.83]
synonym: "(R)-malate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.83]
synonym: "bifunctional L(+)-tartrate dehydrogenase-D(+)-malate (decarboxylating)" RELATED [EC:1.1.1.83]
synonym: "D-malate dehydrogenase activity" EXACT [EC:1.1.1.83]
synonym: "D-malic enzyme" RELATED [EC:1.1.1.83]
xref: EC:1.1.1.83
xref: MetaCyc:1.1.1.83-RXN
is_a: GO:0016615 ! malate dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0046554
name: malate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+." [EC:1.1.1.82]
subset: gosubset_prok
synonym: "(S)-malate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.82]
synonym: "malate NADP dehydrogenase activity" EXACT [EC:1.1.1.82]
synonym: "malic dehydrogenase (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.82]
synonym: "NADP malate dehydrogenase activity" EXACT [EC:1.1.1.82]
synonym: "NADP-linked malate dehydrogenase activity" EXACT [EC:1.1.1.82]
synonym: "NADP-malate dehydrogenase activity" EXACT [EC:1.1.1.82]
xref: EC:1.1.1.82
xref: MetaCyc:MALATE-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016615 ! malate dehydrogenase activity
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0046555
name: acetylxylan esterase activity
namespace: molecular_function
def: "Catalysis of the deacetylation of xylans and xylo-oligosaccharides." [EC:3.1.1.72]
subset: gosubset_prok
xref: EC:3.1.1.72
xref: MetaCyc:3.1.1.72-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0046556
name: alpha-N-arabinofuranosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55]
subset: gosubset_prok
synonym: "alpha-arabinofuranosidase activity" EXACT [EC:3.2.1.55]
synonym: "alpha-arabinosidase activity" EXACT [EC:3.2.1.55]
synonym: "alpha-L-arabinanase activity" EXACT [EC:3.2.1.55]
synonym: "alpha-L-arabinofuranosidase activity" EXACT []
synonym: "alpha-L-arabinofuranoside arabinofuranohydrolase activity" EXACT [EC:3.2.1.55]
synonym: "alpha-L-arabinofuranoside hydrolase activity" EXACT [EC:3.2.1.55]
synonym: "alpha-L-arabinosidase activity" EXACT [EC:3.2.1.55]
synonym: "arabinofuranosidase activity" EXACT [EC:3.2.1.55]
synonym: "arabinosidase activity" EXACT [EC:3.2.1.55]
synonym: "L-arabinosidase activity" EXACT [EC:3.2.1.55]
synonym: "polysaccharide alpha-L-arabinofuranosidase activity" EXACT []
xref: EC:3.2.1.55
xref: MetaCyc:3.2.1.55-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0046557
name: glucan endo-1,6-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the random hydrolysis of 1,6-linkages in 1,6-beta-D-glucans." [EC:3.2.1.75]
synonym: "1,6-beta-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.75]
synonym: "beta-1,6-glucan 6-glucanohydrolase activity" EXACT [EC:3.2.1.75]
synonym: "beta-1,6-glucan hydrolase activity" EXACT [EC:3.2.1.75]
synonym: "beta-1,6-glucanase activity" EXACT [EC:3.2.1.75]
synonym: "beta-1,6-glucanase-pustulanase activity" EXACT [EC:3.2.1.75]
synonym: "beta-1->6-glucan hydrolase activity" EXACT [EC:3.2.1.75]
synonym: "endo-(1,6)-beta-D-glucanase activity" EXACT []
synonym: "endo-(1->6)-beta-D-glucanase activity" EXACT [EC:3.2.1.75]
synonym: "endo-1,6-beta-D-glucanase activity" EXACT [EC:3.2.1.75]
synonym: "endo-1,6-beta-glucanase activity" EXACT [EC:3.2.1.75]
synonym: "endo-beta-1,6-glucanase activity" EXACT [EC:3.2.1.75]
xref: EC:3.2.1.75
xref: MetaCyc:3.2.1.75-RXN
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0046558
name: arabinan endo-1,5-alpha-L-arabinosidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,5-alpha-arabinofuranosidic linkages in 1,5-arabinans." [EC:3.2.1.99]
subset: gosubset_prok
synonym: "1,5-alpha-L-arabinan 1,5-alpha-L-arabinanohydrolase activity" EXACT [EC:3.2.1.99]
synonym: "endo-1,5-a-L-arabinanase activity" EXACT []
synonym: "endo-1,5-alpha-L-arabinanase activity" EXACT [EC:3.2.1.99]
synonym: "endo-alpha-1,5-arabanase activity" EXACT [EC:3.2.1.99]
synonym: "endo-arabanase activity" EXACT [EC:3.2.1.99]
xref: EC:3.2.1.99
xref: MetaCyc:3.2.1.99-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0046559
name: alpha-glucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.139]
subset: gosubset_prok
synonym: "alpha-D-glucosiduronate glucuronohydrolase activity" EXACT [EC:3.2.1.139]
synonym: "alpha-glucosiduronase activity" EXACT [EC:3.2.1.139]
xref: EC:3.2.1.139
xref: MetaCyc:3.2.1.139-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0046560
name: scytalidopepsin B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin." [EC:3.4.23.32]
comment: This term was made obsolete because it represents a gene product.
synonym: "Ganoderma lucidum aspartic proteinase activity" EXACT [EC:3.4.23.32]
synonym: "Ganoderma lucidum carboxyl proteinase activity" EXACT [EC:3.4.23.32]
synonym: "Scytalidium aspartic proteinase B activity" RELATED [EC:3.4.23.32]
synonym: "Scytalidium lignicolum aspartic proteinase B" RELATED [EC:3.4.23.32]
synonym: "SLB" RELATED [EC:3.4.23.32]
xref: EC:3.4.23.32
xref: MetaCyc:3.4.23.32-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0046561
name: penicillopepsin activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen." [EC:3.4.23.20]
comment: This term was made obsolete because it represents a gene product.
synonym: "acid protease A" EXACT []
synonym: "Penicillium aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium caseicolum aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium citrinum acid proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium citrinum aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium cyclopium acid proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium duponti aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium expansum acid proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium expansum aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium janthinellum acid proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium janthinellum aspartic protease activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium janthinellum aspartic proteinase activity" EXACT [EC:3.4.23.20]
synonym: "Penicillium roqueforti acid proteinase activity" EXACT [EC:3.4.23.20]
synonym: "peptidase A activity" BROAD [EC:3.4.23.20]
xref: EC:3.4.23.20
xref: MetaCyc:3.4.23.20-RXN
is_obsolete: true
replaced_by: GO:0004190

[Term]
id: GO:0046562
name: glucose oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a hexose + O2 = a hexno-1,5-lactone + H2O2; includes beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2." [EC:1.1.3.4, GOC:mah]
synonym: "beta-D-glucose oxidase activity" EXACT []
synonym: "beta-D-glucose:oxygen 1-oxido-reductase activity" EXACT [EC:1.1.3.4]
synonym: "beta-D-glucose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.4]
synonym: "beta-D-glucose:quinone oxidoreductase activity" EXACT [EC:1.1.3.4]
synonym: "corylophyline" RELATED [EC:1.1.3.4]
synonym: "D-glucose oxidase activity" EXACT [EC:1.1.3.4]
synonym: "D-glucose-1-oxidase activity" EXACT [EC:1.1.3.4]
synonym: "deoxin-1" RELATED [EC:1.1.3.4]
synonym: "glucose aerodehydrogenase activity" EXACT [EC:1.1.3.4]
synonym: "glucose oxyhydrase activity" EXACT [EC:1.1.3.4]
synonym: "GOD activity" RELATED [EC:1.1.3.4]
synonym: "microcid" RELATED [EC:1.1.3.4]
synonym: "penatin" RELATED [EC:1.1.3.4]
xref: EC:1.1.3.4
xref: MetaCyc:GLUCOSE-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0046563
name: methanol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde." [MetaCyc:METHANOL-OXIDASE-RXN]
comment: Note that EC:1.1.3.31 was deleted from EC as it cannot be distinguished from alcohol oxidase (EC:1.1.3.13).
xref: EC:1.1.3.-
xref: MetaCyc:METHANOL-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0046564
name: oxalate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxalate = formate + CO2." [EC:4.1.1.2]
subset: gosubset_prok
synonym: "oxalate carboxy-lyase (formate-forming)" EXACT [EC:4.1.1.2]
synonym: "oxalate carboxy-lyase activity" EXACT [EC:4.1.1.2]
xref: EC:4.1.1.2
xref: MetaCyc:OXALATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0046565
name: 3-dehydroshikimate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate (protocatechuate) + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate." [EC:4.2.1.-, MetaCyc:DHSHIKIMATE-DEHYDRO-RXN]
xref: EC:4.2.1.-
xref: MetaCyc:DHSHIKIMATE-DEHYDRO-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0046566
name: DOPA dioxygenase activity
namespace: molecular_function
def: "Catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid." [PMID:11711071]
synonym: "dihydroxyphenylalanine dioxygenase activity" EXACT []
xref: MetaCyc:RXN-8460
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0046567
name: aphidicolan-16 beta-ol synthase activity
namespace: molecular_function
def: "Catalysis of the formation of aphidicolan-16 beta-ol from geranylgeranyl diphosphate." [PMID:12149019]
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0046568
name: 3-methylbutanal reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: isoamyl alcohol (3-methylbutanol) + NADP+ = isovaleraldehyde (3-methylbutanal) + NADPH + H+." [EC:1.1.1.265]
synonym: "3-methylbutanol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.265]
synonym: "3-methylbutyraldehyde reductase activity" EXACT []
synonym: "isoamyl alcohol oxidase activity" EXACT []
xref: EC:1.1.1.265
xref: MetaCyc:1.1.1.265-RXN
is_a: GO:0004032 ! aldehyde reductase activity

[Term]
id: GO:0046569
name: glyoxal oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2." [EC:1.2.3.-, PMID:11733005]
synonym: "GLOX" EXACT []
xref: EC:1.2.3.-
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0046570
name: 5-methylthioribulose-1-phosphate 4-dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylthioribulose-1-phosphate = 2,3-diketo-5-methylthio-1-phosphopentane + H2O." [MetaCyc:R145-RXN]
xref: MetaCyc:R145-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0046571
name: aspartate-2-keto-4-methylthiobutyrate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + aspartate = methionine + oxaloacetate." [MetaCyc:R15-RXN]
xref: EC:2.6.1.-
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0046572
name: versicolorin B synthase activity
namespace: molecular_function
def: "Catalysis of the ring closure reaction: versiconal hemiacetal = versicolorin B + H2O." [PMID:8784203]
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0046573
name: lactonohydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of lactone rings (intramolecular cyclic esters) to produce a hydroxyl group and a carboxyl group." [PMID:11640988]
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0046574
name: glycuronidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid." [PMID:10441389, PMID:12044176]
synonym: "glucuronyl hydrolase activity" EXACT []
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0046575
name: rhamnogalacturonan acetylesterase activity
namespace: molecular_function
def: "Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan." [PMID:10801485]
is_a: GO:0008126 ! acetylesterase activity

[Term]
id: GO:0046576
name: rhamnogalacturonase B activity
namespace: molecular_function
def: "Catalysis of the cleavage of (1,2)-alpha-L-Rhap-(1,4)-alpha-D-GalpA glycosidic linkage, generating oligosaccharides terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue." [PMID:8587995, PMID:8720076]
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0046577
name: long-chain-alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O." [EC:1.1.3.20]
synonym: "fatty alcohol oxidase activity" EXACT []
synonym: "fatty alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.20]
synonym: "long-chain fatty acid oxidase activity" EXACT [EC:1.1.3.20]
synonym: "long-chain fatty alcohol oxidase activity" EXACT []
synonym: "long-chain-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.20]
xref: EC:1.1.3.20
xref: MetaCyc:LONG-CHAIN-ALCOHOL-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0046578
name: regulation of Ras protein signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
relationship: regulates GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0046579
name: positive regulation of Ras protein signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
synonym: "activation of Ras protein signal transduction" NARROW []
synonym: "stimulation of Ras protein signal transduction" NARROW []
synonym: "up regulation of Ras protein signal transduction" EXACT []
synonym: "up-regulation of Ras protein signal transduction" EXACT []
synonym: "upregulation of Ras protein signal transduction" EXACT []
is_a: GO:0046578 ! regulation of Ras protein signal transduction
is_a: GO:0051057 ! positive regulation of small GTPase mediated signal transduction
relationship: positively_regulates GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0046580
name: negative regulation of Ras protein signal transduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf]
synonym: "down regulation of Ras protein signal transduction" EXACT []
synonym: "down-regulation of Ras protein signal transduction" EXACT []
synonym: "downregulation of Ras protein signal transduction" EXACT []
synonym: "inhibition of Ras protein signal transduction" NARROW []
is_a: GO:0046578 ! regulation of Ras protein signal transduction
is_a: GO:0051058 ! negative regulation of small GTPase mediated signal transduction
relationship: negatively_regulates GO:0007265 ! Ras protein signal transduction

[Term]
id: GO:0046581
name: intercellular canaliculus
namespace: cellular_component
def: "An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0046582
name: Rap GTPase activator activity
namespace: molecular_function
def: "Increases the rate of GTP hydrolysis by a GTPase of the Rap family." [GOC:mah]
synonym: "Rap GAP activity" EXACT [GOC:pg]
is_a: GO:0005099 ! Ras GTPase activator activity

[Term]
id: GO:0046583
name: cation efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
synonym: "cation efflux permease activity" EXACT []
is_a: GO:0008324 ! cation transmembrane transporter activity
is_a: GO:0015562 ! efflux transmembrane transporter activity

[Term]
id: GO:0046584
name: enniatin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "enniatin metabolism" EXACT []
is_a: GO:0016999 ! antibiotic metabolic process
is_a: GO:0046483 ! heterocycle metabolic process
is_a: GO:0050761 ! depsipeptide metabolic process

[Term]
id: GO:0046585
name: enniatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "enniatin anabolism" EXACT []
synonym: "enniatin biosynthesis" EXACT []
synonym: "enniatin formation" EXACT []
synonym: "enniatin synthesis" EXACT []
is_a: GO:0017000 ! antibiotic biosynthetic process
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0046584 ! enniatin metabolic process
is_a: GO:0050763 ! depsipeptide biosynthetic process

[Term]
id: GO:0046586
name: regulation of calcium-dependent cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:ai]
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: regulates GO:0016339 ! calcium-dependent cell-cell adhesion

[Term]
id: GO:0046587
name: positive regulation of calcium-dependent cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium-dependent cell-cell adhesion." [GOC:ai]
synonym: "activation of calcium-dependent cell-cell adhesion" NARROW []
synonym: "stimulation of calcium-dependent cell-cell adhesion" NARROW []
synonym: "up regulation of calcium-dependent cell-cell adhesion" EXACT []
synonym: "up-regulation of calcium-dependent cell-cell adhesion" EXACT []
synonym: "upregulation of calcium-dependent cell-cell adhesion" EXACT []
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0046586 ! regulation of calcium-dependent cell-cell adhesion
relationship: positively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion

[Term]
id: GO:0046588
name: negative regulation of calcium-dependent cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium-dependent cell-cell adhesion." [GOC:ai]
synonym: "down regulation of calcium-dependent cell-cell adhesion" EXACT []
synonym: "down-regulation of calcium-dependent cell-cell adhesion" EXACT []
synonym: "downregulation of calcium-dependent cell-cell adhesion" EXACT []
synonym: "inhibition of calcium-dependent cell-cell adhesion" NARROW []
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0046586 ! regulation of calcium-dependent cell-cell adhesion
relationship: negatively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion

[Term]
id: GO:0046589
name: ribonuclease T1 activity
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.3]
subset: gosubset_prok
synonym: "Aspergillus oryzae ribonuclease activity" NARROW [EC:3.1.27.3]
synonym: "binase activity" EXACT [EC:3.1.27.3]
synonym: "guanyl-specific RNase activity" EXACT [EC:3.1.27.3]
synonym: "guanyloribonuclease activity" EXACT [EC:3.1.27.3]
synonym: "ribonuclease C2" RELATED [EC:3.1.27.3]
synonym: "ribonuclease Ch" RELATED [EC:3.1.27.3]
synonym: "ribonuclease F1" EXACT []
synonym: "ribonuclease guaninenucleotido-2'-transferase (cyclizing)" EXACT [EC:3.1.27.3]
synonym: "ribonuclease N1" RELATED [EC:3.1.27.3]
synonym: "ribonuclease N3" RELATED [EC:3.1.27.3]
synonym: "ribonuclease PP1" RELATED [EC:3.1.27.3]
synonym: "ribonuclease SA" RELATED [EC:3.1.27.3]
synonym: "ribonuclease U1" RELATED [EC:3.1.27.3]
synonym: "RNase F1" RELATED [EC:3.1.27.3]
synonym: "RNase G" RELATED [EC:3.1.27.3]
synonym: "RNase N1 activity" EXACT [EC:3.1.27.3]
synonym: "RNase N2 activity" EXACT [EC:3.1.27.3]
synonym: "RNase Sa" RELATED [EC:3.1.27.3]
synonym: "RNase T1" RELATED [EC:3.1.27.3]
synonym: "RNase T1 activity" EXACT []
xref: EC:3.1.27.3
xref: MetaCyc:3.1.27.3-RXN
is_a: GO:0004540 ! ribonuclease activity

[Term]
id: GO:0046590
name: embryonic leg morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the leg are generated and organized. Morphogenesis pertains to the creation of form. A leg is a limb on which an animal walks and stands." [GOC:bf]
is_a: GO:0030326 ! embryonic limb morphogenesis
is_a: GO:0035110 ! leg morphogenesis

[Term]
id: GO:0046591
name: embryonic leg joint morphogenesis
namespace: biological_process
def: "The process, occurring in the embryo, by which the anatomical structures of the leg joint are generated and organized. Morphogenesis pertains to the creation of form. A leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner." [GOC:bf, ISBN:0582227089, PMID:12051824]
is_a: GO:0035111 ! leg joint morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0046590 ! embryonic leg morphogenesis

[Term]
id: GO:0046592
name: polyamine oxidase activity
namespace: molecular_function
def: "Catalysis of the oxidative degradation or interconversion of polyamines." [EC:1.5.3.11, PMID:1567380]
synonym: "1-N-acetylspermidine:oxygen oxidoreductase (deaminating)" NARROW [EC:1.5.3.11]
synonym: "N1-acetylspermidine:oxygen oxidoreductase (deaminating)" NARROW [EC:1.5.3.11]
xref: EC:1.5.3.11
xref: MetaCyc:POLYAMINE-OXIDASE-RXN
xref: Reactome:25469 "polyamine oxidase activity"
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0046593
name: mandelonitrile lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde." [EC:4.1.2.10]
synonym: "(R)-oxynitrilase activity" EXACT [EC:4.1.2.10]
synonym: "D-alpha-hydroxynitrile lyase activity" EXACT [EC:4.1.2.10]
synonym: "D-oxynitrilase activity" EXACT [EC:4.1.2.10]
synonym: "hydroxynitrile lyase activity" BROAD []
synonym: "mandelonitrile benzaldehyde-lyase (cyanide-forming)" EXACT [EC:4.1.2.10]
synonym: "mandelonitrile benzaldehyde-lyase activity" EXACT [EC:4.1.2.10]
xref: EC:4.1.2.10
xref: MetaCyc:MANDELONITRILE-LYASE-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0046594
name: maintenance of pole plasm mRNA location
namespace: biological_process
alt_id: GO:0048122
def: "The process of maintaining mRNA in a specific location in the oocyte pole plasm. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:tb]
synonym: "maintenance of oocyte pole plasm mRNA localization" EXACT []
synonym: "maintenance of pole plasm mRNA localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051237 ! maintenance of RNA location
relationship: part_of GO:0019094 ! pole plasm mRNA localization

[Term]
id: GO:0046595
name: establishment of pole plasm mRNA localization
namespace: biological_process
alt_id: GO:0048121
def: "Any process by which mRNA is recruited to the oocyte pole plasm." [GOC:bf]
synonym: "establishment of oocyte pole plasm mRNA localization" EXACT []
is_a: GO:0051236 ! establishment of RNA localization
relationship: part_of GO:0019094 ! pole plasm mRNA localization

[Term]
id: GO:0046596
name: regulation of virion penetration into host cell
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the introduction of virus particles into the cell." [GOC:ai, GOC:tb]
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
is_a: GO:0050792 ! regulation of viral reproduction
relationship: regulates GO:0019063 ! virion penetration into host cell

[Term]
id: GO:0046597
name: negative regulation of virion penetration into host cell
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the introduction of virus particles into the cell." [GOC:ai, GOC:tb]
synonym: "down regulation of virion penetration into host" EXACT []
synonym: "down-regulation of virion penetration into host" EXACT []
synonym: "downregulation of virion penetration into host" EXACT []
synonym: "inhibition of virion penetration into host" NARROW []
is_a: GO:0046596 ! regulation of virion penetration into host cell
is_a: GO:0048525 ! negative regulation of viral reproduction
relationship: negatively_regulates GO:0019063 ! virion penetration into host cell

[Term]
id: GO:0046598
name: positive regulation of virion penetration into host cell
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the introduction of virus particles into the cell." [GOC:ai, GOC:tb]
synonym: "activation of virion penetration into host" NARROW []
synonym: "stimulation of virion penetration into host" NARROW []
synonym: "up regulation of virion penetration into host" EXACT []
synonym: "up-regulation of virion penetration into host" EXACT []
synonym: "upregulation of virion penetration into host" EXACT []
is_a: GO:0046596 ! regulation of virion penetration into host cell
is_a: GO:0048524 ! positive regulation of viral reproduction
relationship: positively_regulates GO:0019063 ! virion penetration into host cell

[Term]
id: GO:0046599
name: regulation of centriole replication
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole." [GOC:ai]
is_a: GO:0010824 ! regulation of centrosome duplication
relationship: regulates GO:0007099 ! centriole replication

[Term]
id: GO:0046600
name: negative regulation of centriole replication
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of centriole replication." [GOC:ai]
synonym: "down regulation of centriole replication" EXACT []
synonym: "down-regulation of centriole replication" EXACT []
synonym: "downregulation of centriole replication" EXACT []
synonym: "inhibition of centriole replication" NARROW []
is_a: GO:0046599 ! regulation of centriole replication
is_a: GO:0046606 ! negative regulation of centrosome cycle
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
relationship: negatively_regulates GO:0007099 ! centriole replication

[Term]
id: GO:0046601
name: positive regulation of centriole replication
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of centriole replication." [GOC:ai]
synonym: "activation of centriole replication" NARROW []
synonym: "stimulation of centriole replication" NARROW []
synonym: "up regulation of centriole replication" EXACT []
synonym: "up-regulation of centriole replication" EXACT []
synonym: "upregulation of centriole replication" EXACT []
is_a: GO:0046599 ! regulation of centriole replication
is_a: GO:0046607 ! positive regulation of centrosome cycle
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
relationship: positively_regulates GO:0007099 ! centriole replication

[Term]
id: GO:0046602
name: regulation of mitotic centrosome separation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis." [GOC:ai]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0046605 ! regulation of centrosome cycle
relationship: regulates GO:0007100 ! mitotic centrosome separation

[Term]
id: GO:0046603
name: negative regulation of mitotic centrosome separation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of centrosome separation." [GOC:ai]
synonym: "down regulation of mitotic centrosome separation" EXACT []
synonym: "down-regulation of mitotic centrosome separation" EXACT []
synonym: "downregulation of mitotic centrosome separation" EXACT []
synonym: "inhibition of mitotic centrosome separation" NARROW []
is_a: GO:0046602 ! regulation of mitotic centrosome separation
is_a: GO:0046606 ! negative regulation of centrosome cycle
relationship: negatively_regulates GO:0007100 ! mitotic centrosome separation

[Term]
id: GO:0046604
name: positive regulation of mitotic centrosome separation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of centrosome separation." [GOC:ai]
synonym: "activation of mitotic centrosome separation" NARROW []
synonym: "stimulation of mitotic centrosome separation" NARROW []
synonym: "up regulation of mitotic centrosome separation" EXACT []
synonym: "up-regulation of mitotic centrosome separation" EXACT []
synonym: "upregulation of mitotic centrosome separation" EXACT []
is_a: GO:0046602 ! regulation of mitotic centrosome separation
is_a: GO:0046607 ! positive regulation of centrosome cycle
relationship: positively_regulates GO:0007100 ! mitotic centrosome separation

[Term]
id: GO:0046605
name: regulation of centrosome cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation." [GOC:ai]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
relationship: regulates GO:0007098 ! centrosome cycle

[Term]
id: GO:0046606
name: negative regulation of centrosome cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the centrosome cycle." [GOC:ai]
synonym: "down regulation of centrosome cycle" EXACT []
synonym: "down-regulation of centrosome cycle" EXACT []
synonym: "downregulation of centrosome cycle" EXACT []
synonym: "inhibition of centrosome cycle" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0046605 ! regulation of centrosome cycle
relationship: negatively_regulates GO:0007098 ! centrosome cycle

[Term]
id: GO:0046607
name: positive regulation of centrosome cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the centrosome cycle." [GOC:ai]
synonym: "activation of centrosome cycle" NARROW []
synonym: "stimulation of centrosome cycle" NARROW []
synonym: "up regulation of centrosome cycle" EXACT []
synonym: "up-regulation of centrosome cycle" EXACT []
synonym: "upregulation of centrosome cycle" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0046605 ! regulation of centrosome cycle
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0007098 ! centrosome cycle

[Term]
id: GO:0046608
name: carotenoid isomerase activity
namespace: molecular_function
def: "Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids." [PMID:11884677]
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0046609
name: voltage-gated sulfate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + solute(in) = solute(in) + sulfate(out), by a channel in a cell membrane whose opening is governed by the membrane potential." [GOC:mah]
synonym: "prestin" NARROW []
synonym: "voltage gated sulfate antiporter activity" EXACT []
synonym: "voltage-dependent sulfate antiporter activity" EXACT []
synonym: "voltage-sensitive sulfate antiporter activity" EXACT []
synonym: "voltage-sensitive sulphate antiporter activity" EXACT []
is_a: GO:0015297 ! antiporter activity

[Term]
id: GO:0046610
name: lysosomal proton-transporting V-type ATPase, V0 domain
namespace: cellular_component
def: "The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane." [GOC:mah]
synonym: "lysosomal hydrogen ion-transporting ATPase V0 domain" EXACT []
is_a: GO:0000220 ! vacuolar proton-transporting V-type ATPase, V0 domain
relationship: part_of GO:0046611 ! lysosomal proton-transporting V-type ATPase complex

[Term]
id: GO:0046611
name: lysosomal proton-transporting V-type ATPase complex
namespace: cellular_component
def: "A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]
synonym: "lysosomal hydrogen-translocating V-type ATPase complex" EXACT []
synonym: "lysosomal membrane hydrogen-transporting ATPase" BROAD []
is_a: GO:0016471 ! vacuolar proton-transporting V-type ATPase complex
relationship: part_of GO:0005765 ! lysosomal membrane

[Term]
id: GO:0046612
name: lysosomal proton-transporting V-type ATPase, V1 domain
namespace: cellular_component
def: "The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane." [GOC:mah]
synonym: "lysosomal hydrogen ion-transporting ATPase V1 domain" EXACT []
is_a: GO:0000221 ! vacuolar proton-transporting V-type ATPase, V1 domain
relationship: part_of GO:0046611 ! lysosomal proton-transporting V-type ATPase complex

[Term]
id: GO:0046615
name: re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. The resumption of the Saccharomyces mitotic cell division cycle by pheromone-arrested cells that have not mated." [GOC:krc, PMID:9927449]
comment: This term was made obsolete because there is no evidence that this process is unique to Saccharomyces.
is_obsolete: true
replaced_by: GO:0000321

[Term]
id: GO:0046617
name: nucleolar size increase (sensu Saccharomyces)
namespace: biological_process
def: "OBSOLETE. The process of nucleolar expansion, as seen in Saccharomyces." [GOC:ai]
comment: This term was made obsolete because it does not describe a biological process.
is_obsolete: true
consider: GO:0007571
consider: GO:0007576

[Term]
id: GO:0046618
name: drug export
namespace: biological_process
def: "The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle." [GOC:go_curators]
is_a: GO:0015893 ! drug transport

[Term]
id: GO:0046619
name: optic placode formation involved in camera-type eye
namespace: biological_process
def: "Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, http://cancerweb.ncl.ac.uk/]
synonym: "optic placode formation in camera-type eye" EXACT []
synonym: "optic placode formation involved in camera-style eye" EXACT []
is_a: GO:0001743 ! optic placode formation
relationship: part_of GO:0060900 ! embryonic camera-type eye formation

[Term]
id: GO:0046620
name: regulation of organ growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
is_a: GO:0040008 ! regulation of growth
relationship: regulates GO:0035265 ! organ growth

[Term]
id: GO:0046621
name: negative regulation of organ growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
is_a: GO:0045926 ! negative regulation of growth
is_a: GO:0046620 ! regulation of organ growth
relationship: negatively_regulates GO:0035265 ! organ growth

[Term]
id: GO:0046622
name: positive regulation of organ growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb]
is_a: GO:0045927 ! positive regulation of growth
is_a: GO:0046620 ! regulation of organ growth
relationship: positively_regulates GO:0035265 ! organ growth

[Term]
id: GO:0046623
name: sphingolipid-translocating ATPase activity
namespace: molecular_function
def: "Catalysis of the movement of sphingolipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP." [GOC:ai, PMID:12034738]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "sphingolipid flippase activity" EXACT []
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances
is_a: GO:0046624 ! sphingolipid transporter activity

[Term]
id: GO:0046624
name: sphingolipid transporter activity
namespace: molecular_function
def: "Enables the directed movement of sphingolipids into, out of, within or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0005319 ! lipid transporter activity

[Term]
id: GO:0046625
name: sphingolipid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with sphingolipids, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0046626
name: regulation of insulin receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
synonym: "regulation of insulin receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0008286 ! insulin receptor signaling pathway

[Term]
id: GO:0046627
name: negative regulation of insulin receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
synonym: "down regulation of insulin receptor signaling pathway" EXACT []
synonym: "down-regulation of insulin receptor signaling pathway" EXACT []
synonym: "downregulation of insulin receptor signaling pathway" EXACT []
synonym: "inhibition of insulin receptor signaling pathway" NARROW []
synonym: "negative regulation of insulin receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0046626 ! regulation of insulin receptor signaling pathway
is_a: GO:0048585 ! negative regulation of response to stimulus
relationship: negatively_regulates GO:0008286 ! insulin receptor signaling pathway

[Term]
id: GO:0046628
name: positive regulation of insulin receptor signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of insulin receptor signaling." [GOC:bf]
synonym: "activation of insulin receptor signaling pathway" NARROW []
synonym: "positive regulation of insulin receptor signalling pathway" EXACT []
synonym: "stimulation of insulin receptor signaling pathway" NARROW []
synonym: "up regulation of insulin receptor signaling pathway" EXACT []
synonym: "up-regulation of insulin receptor signaling pathway" EXACT []
synonym: "upregulation of insulin receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0046626 ! regulation of insulin receptor signaling pathway
is_a: GO:0048584 ! positive regulation of response to stimulus
relationship: positively_regulates GO:0008286 ! insulin receptor signaling pathway

[Term]
id: GO:0046629
name: gamma-delta T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:add]
synonym: "gamma-delta T lymphocyte activation" EXACT []
synonym: "gamma-delta T-cell activation" EXACT []
synonym: "gamma-delta T-lymphocyte activation" EXACT []
is_a: GO:0042110 ! T cell activation

[Term]
id: GO:0046630
name: gamma-delta T cell proliferation
namespace: biological_process
def: "The expansion of a gamma-delta T cell population by cell division." [GOC:ai]
synonym: "gamma-delta T lymphocyte proliferation" EXACT []
synonym: "gamma-delta T-cell proliferation" EXACT []
synonym: "gamma-delta T-lymphocyte proliferation" EXACT []
is_a: GO:0042098 ! T cell proliferation
is_a: GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0046631
name: alpha-beta T cell activation
namespace: biological_process
def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:add]
synonym: "alpha-beta T lymphocyte activation" EXACT []
synonym: "alpha-beta T-cell activation" EXACT []
synonym: "alpha-beta T-lymphocyte activation" EXACT []
is_a: GO:0042110 ! T cell activation

[Term]
id: GO:0046632
name: alpha-beta T cell differentiation
namespace: biological_process
def: "The process whereby a precursor cell type acquires the specialized features of an alpha-beta T cell." [GOC:ai]
synonym: "alpha-beta T lymphocyte differentiation" EXACT []
synonym: "alpha-beta T-cell differentiation" EXACT []
synonym: "alpha-beta T-lymphocyte differentiation" EXACT []
is_a: GO:0030217 ! T cell differentiation
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0046633
name: alpha-beta T cell proliferation
namespace: biological_process
def: "The expansion of an alpha-beta T cell population by cell division." [GOC:ai]
synonym: "alpha-beta T lymphocyte proliferation" EXACT []
synonym: "alpha-beta T-cell proliferation" EXACT []
synonym: "alpha-beta T-lymphocyte proliferation" EXACT []
is_a: GO:0042098 ! T cell proliferation
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0046634
name: regulation of alpha-beta T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai]
synonym: "regulation of alpha-beta T lymphocyte activation" EXACT []
synonym: "regulation of alpha-beta T-cell activation" EXACT []
synonym: "regulation of alpha-beta T-lymphocyte activation" EXACT []
is_a: GO:0050863 ! regulation of T cell activation
relationship: regulates GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0046635
name: positive regulation of alpha-beta T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai]
synonym: "activation of alpha-beta T cell activation" NARROW []
synonym: "positive regulation of alpha-beta T lymphocyte activation" EXACT []
synonym: "positive regulation of alpha-beta T-cell activation" EXACT []
synonym: "positive regulation of alpha-beta T-lymphocyte activation" EXACT []
synonym: "stimulation of alpha-beta T cell activation" NARROW []
synonym: "up regulation of alpha-beta T cell activation" EXACT []
synonym: "up-regulation of alpha-beta T cell activation" EXACT []
synonym: "upregulation of alpha-beta T cell activation" EXACT []
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
is_a: GO:0050870 ! positive regulation of T cell activation
relationship: positively_regulates GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0046636
name: negative regulation of alpha-beta T cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai]
synonym: "down regulation of alpha-beta T cell activation" EXACT []
synonym: "down-regulation of alpha-beta T cell activation" EXACT []
synonym: "downregulation of alpha-beta T cell activation" EXACT []
synonym: "inhibition of alpha-beta T cell activation" NARROW []
synonym: "negative regulation of alpha-beta T lymphocyte activation" EXACT []
synonym: "negative regulation of alpha-beta T-cell activation" EXACT []
synonym: "negative regulation of alpha-beta T-lymphocyte activation" EXACT []
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
is_a: GO:0050868 ! negative regulation of T cell activation
relationship: negatively_regulates GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0046637
name: regulation of alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai]
synonym: "regulation of alpha-beta T lymphocyte differentiation" EXACT []
synonym: "regulation of alpha-beta T-cell differentiation" EXACT []
synonym: "regulation of alpha-beta T-lymphocyte differentiation" EXACT []
is_a: GO:0045580 ! regulation of T cell differentiation
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
relationship: regulates GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0046638
name: positive regulation of alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai]
synonym: "activation of alpha-beta T cell differentiation" NARROW []
synonym: "positive regulation of alpha-beta T lymphocyte differentiation" EXACT []
synonym: "positive regulation of alpha-beta T-cell differentiation" EXACT []
synonym: "positive regulation of alpha-beta T-lymphocyte differentiation" EXACT []
synonym: "stimulation of alpha-beta T cell differentiation" NARROW []
synonym: "up regulation of alpha-beta T cell differentiation" EXACT []
synonym: "up-regulation of alpha-beta T cell differentiation" EXACT []
synonym: "upregulation of alpha-beta T cell differentiation" EXACT []
is_a: GO:0045582 ! positive regulation of T cell differentiation
is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation
relationship: positively_regulates GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0046639
name: negative regulation of alpha-beta T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai]
synonym: "down regulation of alpha-beta T cell differentiation" EXACT []
synonym: "down-regulation of alpha-beta T cell differentiation" EXACT []
synonym: "downregulation of alpha-beta T cell differentiation" EXACT []
synonym: "inhibition of alpha-beta T cell differentiation" NARROW []
synonym: "negative regulation of alpha-beta T lymphocyte differentiation" EXACT []
synonym: "negative regulation of alpha-beta T-cell differentiation" EXACT []
synonym: "negative regulation of alpha-beta T-lymphocyte differentiation" EXACT []
is_a: GO:0045581 ! negative regulation of T cell differentiation
is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation
relationship: negatively_regulates GO:0046632 ! alpha-beta T cell differentiation

[Term]
id: GO:0046640
name: regulation of alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai]
synonym: "regulation of alpha-beta T lymphocyte proliferation" EXACT []
synonym: "regulation of alpha-beta T-cell proliferation" EXACT []
synonym: "regulation of alpha-beta T-lymphocyte proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
relationship: regulates GO:0046633 ! alpha-beta T cell proliferation

[Term]
id: GO:0046641
name: positive regulation of alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai]
synonym: "activation of alpha-beta T cell proliferation" NARROW []
synonym: "positive regulation of alpha-beta T lymphocyte proliferation" EXACT []
synonym: "positive regulation of alpha-beta T-cell proliferation" EXACT []
synonym: "positive regulation of alpha-beta T-lymphocyte proliferation" EXACT []
synonym: "stimulation of alpha-beta T cell proliferation" NARROW []
synonym: "up regulation of alpha-beta T cell proliferation" EXACT []
synonym: "up-regulation of alpha-beta T cell proliferation" EXACT []
synonym: "upregulation of alpha-beta T cell proliferation" EXACT []
is_a: GO:0042102 ! positive regulation of T cell proliferation
is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation
is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation
relationship: positively_regulates GO:0046633 ! alpha-beta T cell proliferation

[Term]
id: GO:0046642
name: negative regulation of alpha-beta T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai]
synonym: "down regulation of alpha-beta T cell proliferation" EXACT []
synonym: "down-regulation of alpha-beta T cell proliferation" EXACT []
synonym: "downregulation of alpha-beta T cell proliferation" EXACT []
synonym: "inhibition of alpha-beta T cell proliferation" NARROW []
synonym: "negative regulation of alpha-beta T lymphocyte proliferation" EXACT []
synonym: "negative regulation of alpha-beta T-cell proliferation" EXACT []
synonym: "negative regulation of alpha-beta T-lymphocyte proliferation" EXACT []
is_a: GO:0042130 ! negative regulation of T cell proliferation
is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation
is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation
relationship: negatively_regulates GO:0046633 ! alpha-beta T cell proliferation

[Term]
id: GO:0046643
name: regulation of gamma-delta T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai]
synonym: "regulation of gamma-delta T lymphocyte activation" EXACT []
synonym: "regulation of gamma-delta T-cell activation" EXACT []
synonym: "regulation of gamma-delta T-lymphocyte activation" EXACT []
is_a: GO:0050863 ! regulation of T cell activation
relationship: regulates GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0046644
name: negative regulation of gamma-delta T cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai]
synonym: "down regulation of gamma-delta T cell activation" EXACT []
synonym: "down-regulation of gamma-delta T cell activation" EXACT []
synonym: "downregulation of gamma-delta T cell activation" EXACT []
synonym: "inhibition of gamma-delta T cell activation" NARROW []
synonym: "negative regulation of gamma-delta T lymphocyte activation" EXACT []
synonym: "negative regulation of gamma-delta T-cell activation" EXACT []
synonym: "negative regulation of gamma-delta T-lymphocyte activation" EXACT []
is_a: GO:0046643 ! regulation of gamma-delta T cell activation
is_a: GO:0050868 ! negative regulation of T cell activation
relationship: negatively_regulates GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0046645
name: positive regulation of gamma-delta T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai]
synonym: "activation of gamma-delta T cell activation" NARROW []
synonym: "positive regulation of gamma-delta T lymphocyte activation" EXACT []
synonym: "positive regulation of gamma-delta T-cell activation" EXACT []
synonym: "positive regulation of gamma-delta T-lymphocyte activation" EXACT []
synonym: "stimulation of gamma-delta T cell activation" NARROW []
synonym: "up regulation of gamma-delta T cell activation" EXACT []
synonym: "up-regulation of gamma-delta T cell activation" EXACT []
synonym: "upregulation of gamma-delta T cell activation" EXACT []
is_a: GO:0046643 ! regulation of gamma-delta T cell activation
is_a: GO:0050870 ! positive regulation of T cell activation
relationship: positively_regulates GO:0046629 ! gamma-delta T cell activation

[Term]
id: GO:0046646
name: regulation of gamma-delta T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai]
synonym: "regulation of gamma-delta T lymphocyte proliferation" EXACT []
synonym: "regulation of gamma-delta T-cell proliferation" EXACT []
synonym: "regulation of gamma-delta T-lymphocyte proliferation" EXACT []
is_a: GO:0042129 ! regulation of T cell proliferation
is_a: GO:0046643 ! regulation of gamma-delta T cell activation
relationship: regulates GO:0046630 ! gamma-delta T cell proliferation

[Term]
id: GO:0046647
name: negative regulation of gamma-delta T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai]
synonym: "down regulation of gamma-delta T cell proliferation" EXACT []
synonym: "down-regulation of gamma-delta T cell proliferation" EXACT []
synonym: "downregulation of gamma-delta T cell proliferation" EXACT []
synonym: "inhibition of gamma-delta T cell proliferation" NARROW []
synonym: "negative regulation of gamma-delta T lymphocyte proliferation" EXACT []
synonym: "negative regulation of gamma-delta T-cell proliferation" EXACT []
synonym: "negative regulation of gamma-delta T-lymphocyte proliferation" EXACT []
is_a: GO:0042130 ! negative regulation of T cell proliferation
is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation
is_a: GO:0046646 ! regulation of gamma-delta T cell proliferation
relationship: negatively_regulates GO:0046630 ! gamma-delta T cell proliferation

[Term]
id: GO:0046648
name: positive regulation of gamma-delta T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai]
synonym: "activation of gamma-delta T cell proliferation" NARROW []
synonym: "positive regulation of gamma-delta T lymphocyte proliferation" EXACT []
synonym: "positive regulation of gamma-delta T-cell proliferation" EXACT []
synonym: "positive regulation of gamma-delta T-lymphocyte proliferation" EXACT []
synonym: "stimulation of gamma-delta T cell proliferation" NARROW []
synonym: "up regulation of gamma-delta T cell proliferation" EXACT []
synonym: "up-regulation of gamma-delta T cell proliferation" EXACT []
synonym: "upregulation of gamma-delta T cell proliferation" EXACT []
is_a: GO:0042102 ! positive regulation of T cell proliferation
is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation
is_a: GO:0046646 ! regulation of gamma-delta T cell proliferation
relationship: positively_regulates GO:0046630 ! gamma-delta T cell proliferation

[Term]
id: GO:0046649
name: lymphocyte activation
namespace: biological_process
def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735140]
is_a: GO:0045321 ! leukocyte activation

[Term]
id: GO:0046651
name: lymphocyte proliferation
namespace: biological_process
def: "The expansion of a lymphocyte population by cell division." [GOC:ai]
is_a: GO:0032943 ! mononuclear cell proliferation
is_a: GO:0046649 ! lymphocyte activation

[Term]
id: GO:0046653
name: tetrahydrofolate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin moiety." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "tetrahydrofolate metabolism" EXACT []
is_a: GO:0006760 ! folic acid and derivative metabolic process
is_a: GO:0042558 ! pteridine and derivative metabolic process

[Term]
id: GO:0046654
name: tetrahydrofolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin moiety." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "tetrahydrofolate anabolism" EXACT []
synonym: "tetrahydrofolate biosynthesis" EXACT []
synonym: "tetrahydrofolate formation" EXACT []
synonym: "tetrahydrofolate synthesis" EXACT []
xref: MetaCyc:FOLSYN-PWY
is_a: GO:0009396 ! folic acid and derivative biosynthetic process
is_a: GO:0042559 ! pteridine and derivative biosynthetic process
is_a: GO:0046653 ! tetrahydrofolate metabolic process

[Term]
id: GO:0046655
name: folic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "folate metabolic process" EXACT []
synonym: "folate metabolism" EXACT []
synonym: "folic acid metabolism" EXACT []
synonym: "vitamin B9 metabolic process" EXACT []
synonym: "vitamin B9 metabolism" EXACT []
synonym: "vitamin M metabolic process" EXACT []
synonym: "vitamin M metabolism" EXACT []
xref: Reactome:196757 "Metabolism of folate and pterines"
xref: Reactome:448499 "Metabolism of folate and pterines"
xref: Reactome:469629 "Metabolism of folate and pterines"
xref: Reactome:487348 "Metabolism of folate and pterines"
xref: Reactome:507299 "Metabolism of folate and pterines"
xref: Reactome:517313 "Metabolism of folate and pterines"
xref: Reactome:526198 "Metabolism of folate and pterines"
xref: Reactome:531084 "Metabolism of folate and pterines"
xref: Reactome:536457 "Metabolism of folate and pterines"
xref: Reactome:542161 "Metabolism of folate and pterines"
xref: Reactome:547519 "Metabolism of folate and pterines"
xref: Reactome:552112 "Metabolism of folate and pterines"
xref: Reactome:557704 "Metabolism of folate and pterines"
xref: Reactome:568319 "Metabolism of folate and pterines"
xref: Reactome:581521 "Metabolism of folate and pterines"
xref: Reactome:592408 "Metabolism of folate and pterines"
xref: Reactome:595338 "Metabolism of folate and pterines"
xref: Reactome:597306 "Metabolism of folate and pterines"
xref: Reactome:598107 "Metabolism of folate and pterines"
xref: Reactome:599607 "Metabolism of folate and pterines"
xref: Reactome:600551 "Metabolism of folate and pterines"
xref: Reactome:602411 "Metabolism of folate and pterines"
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0006760 ! folic acid and derivative metabolic process
is_a: GO:0006767 ! water-soluble vitamin metabolic process
is_a: GO:0042558 ! pteridine and derivative metabolic process

[Term]
id: GO:0046656
name: folic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid." [GOC:ai]
subset: gosubset_prok
synonym: "folate biosynthesis" EXACT []
synonym: "folate biosynthetic process" EXACT []
synonym: "folic acid anabolism" EXACT []
synonym: "folic acid biosynthesis" EXACT []
synonym: "folic acid formation" EXACT []
synonym: "folic acid synthesis" EXACT []
synonym: "vitamin B9 biosynthesis" EXACT []
synonym: "vitamin B9 biosynthetic process" EXACT []
synonym: "vitamin M biosynthesis" EXACT []
synonym: "vitamin M biosynthetic process" EXACT []
xref: MetaCyc:FOLSYN-PWY
xref: Wikipedia:Folic_acid
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0009396 ! folic acid and derivative biosynthetic process
is_a: GO:0042364 ! water-soluble vitamin biosynthetic process
is_a: GO:0042559 ! pteridine and derivative biosynthetic process
is_a: GO:0046655 ! folic acid metabolic process

[Term]
id: GO:0046657
name: folic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of folic acid, pteroylglutamic acid." [GOC:ai]
subset: gosubset_prok
synonym: "folate catabolic process" EXACT []
synonym: "folate catabolism" EXACT []
synonym: "folic acid breakdown" EXACT []
synonym: "folic acid catabolism" EXACT []
synonym: "folic acid degradation" EXACT []
synonym: "vitamin B9 catabolic process" EXACT []
synonym: "vitamin B9 catabolism" EXACT []
synonym: "vitamin M catabolic process" EXACT []
synonym: "vitamin M catabolism" EXACT []
is_a: GO:0009063 ! cellular amino acid catabolic process
is_a: GO:0009397 ! folic acid and derivative catabolic process
is_a: GO:0042365 ! water-soluble vitamin catabolic process
is_a: GO:0042560 ! pteridine and derivative catabolic process
is_a: GO:0046655 ! folic acid metabolic process

[Term]
id: GO:0046658
name: anchored to plasma membrane
namespace: cellular_component
def: "Tethered to the plasma membrane by a covalently attached anchor, such as a lipid moiety, that is embedded in the membrane. When used to describe a protein, indicates that the peptide sequence does not span the membrane." [GOC:mah]
synonym: "plasma membrane, GPI-anchored" NARROW []
is_a: GO:0031225 ! anchored to membrane
is_a: GO:0031226 ! intrinsic to plasma membrane

[Term]
id: GO:0046659
name: digestive hormone activity
namespace: molecular_function
def: "The action characteristic of a hormone that takes part in the digestion process." [GOC:ai]
synonym: "secretin" NARROW []
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0046660
name: female sex differentiation
namespace: biological_process
def: "The establishment of the sex of a female organism by physical differentiation." [GOC:bf]
is_a: GO:0007548 ! sex differentiation
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0046661
name: male sex differentiation
namespace: biological_process
def: "The establishment of the sex of a male organism by physical differentiation." [GOC:bf]
is_a: GO:0007548 ! sex differentiation
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0046662
name: regulation of oviposition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium." [GOC:ai]
is_a: GO:0050795 ! regulation of behavior
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0018991 ! oviposition

[Term]
id: GO:0046663
name: dorsal closure, leading edge cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a leading edge cell, the dorsal-most cells of the epidermis that migrates during dorsal closure." [GOC:ai, PMID:12147138]
is_a: GO:0035026 ! leading edge cell differentiation
relationship: part_of GO:0007392 ! initiation of dorsal closure

[Term]
id: GO:0046664
name: dorsal closure, amnioserosa morphology change
namespace: biological_process
def: "The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo." [PMID:12147138]
is_a: GO:0048598 ! embryonic morphogenesis
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0007391 ! dorsal closure

[Term]
id: GO:0046665
name: amnioserosa maintenance
namespace: biological_process
def: "Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis." [GOC:bf]
is_a: GO:0001894 ! tissue homeostasis
relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm

[Term]
id: GO:0046666
name: retinal cell programmed cell death
namespace: biological_process
def: "Programmed cell death that occurs in the developing retina." [GOC:bf]
synonym: "programmed cell death, retina cells" EXACT []
synonym: "programmed cell death, retinal cells" EXACT []
synonym: "retina cell programmed cell death" EXACT []
synonym: "retina programmed cell death" EXACT []
synonym: "retinal programmed cell death" EXACT []
is_a: GO:0010623 ! developmental programmed cell death
relationship: part_of GO:0048592 ! eye morphogenesis

[Term]
id: GO:0046667
name: compound eye retinal cell programmed cell death
namespace: biological_process
def: "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672]
is_a: GO:0046666 ! retinal cell programmed cell death
relationship: part_of GO:0001745 ! compound eye morphogenesis

[Term]
id: GO:0046668
name: regulation of retinal cell programmed cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
synonym: "regulation of retinal programmed cell death" EXACT [GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0046666 ! retinal cell programmed cell death

[Term]
id: GO:0046669
name: regulation of compound eye retinal cell programmed cell death
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
synonym: "regulation of retinal cell programmed cell death" BROAD []
is_a: GO:0046668 ! regulation of retinal cell programmed cell death
relationship: regulates GO:0046667 ! compound eye retinal cell programmed cell death

[Term]
id: GO:0046670
name: positive regulation of retinal cell programmed cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
synonym: "activation of retinal programmed cell death" NARROW []
synonym: "positive regulation of retinal programmed cell death" EXACT [GOC:tb]
synonym: "stimulation of retinal programmed cell death" NARROW []
synonym: "up regulation of retinal programmed cell death" EXACT []
synonym: "up-regulation of retinal programmed cell death" EXACT []
synonym: "upregulation of retinal programmed cell death" EXACT []
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:0046668 ! regulation of retinal cell programmed cell death
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0046666 ! retinal cell programmed cell death

[Term]
id: GO:0046671
name: negative regulation of retinal cell programmed cell death
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb]
synonym: "down regulation of retinal programmed cell death" EXACT []
synonym: "down-regulation of retinal programmed cell death" EXACT []
synonym: "downregulation of retinal programmed cell death" EXACT []
synonym: "inhibition of retinal programmed cell death" NARROW []
synonym: "negative regulation of retinal programmed cell death" EXACT [GOC:tb]
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:0046668 ! regulation of retinal cell programmed cell death
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0046666 ! retinal cell programmed cell death

[Term]
id: GO:0046672
name: positive regulation of compound eye retinal cell programmed cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
synonym: "activation of retinal cell programmed cell death" BROAD []
synonym: "positive regulation of retinal cell programmed cell death" BROAD []
synonym: "stimulation of retinal cell programmed cell death" BROAD []
synonym: "up regulation of retinal cell programmed cell death" BROAD []
synonym: "up-regulation of retinal cell programmed cell death" BROAD []
synonym: "upregulation of retinal cell programmed cell death" BROAD []
is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death
is_a: GO:0046670 ! positive regulation of retinal cell programmed cell death
relationship: positively_regulates GO:0046667 ! compound eye retinal cell programmed cell death

[Term]
id: GO:0046673
name: negative regulation of compound eye retinal cell programmed cell death
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai]
synonym: "down regulation of retinal cell programmed cell death" BROAD []
synonym: "down-regulation of retinal cell programmed cell death" BROAD []
synonym: "downregulation of retinal cell programmed cell death" BROAD []
synonym: "inhibition of retinal cell programmed cell death" BROAD []
synonym: "negative regulation of retina cell programmed cell death" BROAD []
synonym: "negative regulation of retinal cell programmed cell death" BROAD []
is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death
is_a: GO:0046671 ! negative regulation of retinal cell programmed cell death
relationship: negatively_regulates GO:0046667 ! compound eye retinal cell programmed cell death

[Term]
id: GO:0046674
name: induction of retinal programmed cell death
namespace: biological_process
def: "A process which directly activates any of the steps required for programmed cell death in the retina." [GOC:ai]
is_a: GO:0012502 ! induction of programmed cell death
is_a: GO:0046670 ! positive regulation of retinal cell programmed cell death

[Term]
id: GO:0046675
name: induction of compound eye retinal cell programmed cell death
namespace: biological_process
def: "A process that directly activates any of the steps required for programmed cell death in the compound eye retina." [GOC:ai]
synonym: "induction of retinal cell programmed cell death" BROAD []
is_a: GO:0046672 ! positive regulation of compound eye retinal cell programmed cell death
is_a: GO:0046674 ! induction of retinal programmed cell death

[Term]
id: GO:0046676
name: negative regulation of insulin secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of insulin." [GOC:ai]
synonym: "down regulation of insulin secretion" EXACT []
synonym: "down-regulation of insulin secretion" EXACT []
synonym: "downregulation of insulin secretion" EXACT []
synonym: "inhibition of insulin secretion" NARROW []
is_a: GO:0050796 ! regulation of insulin secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
relationship: negatively_regulates GO:0030073 ! insulin secretion

[Term]
id: GO:0046677
name: response to antibiotic
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:ai, GOC:ef]
subset: gosubset_prok
synonym: "antibiotic susceptibility/resistance" RELATED []
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0046678
name: response to bacteriocin
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "bacteriocin susceptibility/resistance" RELATED []
is_a: GO:0046677 ! response to antibiotic

[Term]
id: GO:0046679
name: response to streptomycin
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [http://cancerweb.ncl.ac.uk/]
synonym: "streptomycin susceptibility/resistance" RELATED []
is_a: GO:0046677 ! response to antibiotic

[Term]
id: GO:0046680
name: response to DDT
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "DDT resistance" RELATED []
synonym: "DDT susceptibility/resistance" RELATED []
is_a: GO:0017085 ! response to insecticide

[Term]
id: GO:0046681
name: response to carbamate
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "carbamate resistance" RELATED []
synonym: "carbamate susceptibility/resistance" RELATED []
is_a: GO:0017085 ! response to insecticide

[Term]
id: GO:0046682
name: response to cyclodiene
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclodiene stimulus. A cyclodiene is any organic insecticide (as dieldrin or chlordane) with a chlorinated methylene group forming a bridge across a 6-membered carbon ring." [ISBN:0877797099]
synonym: "cyclodiene resistance" RELATED []
synonym: "cyclodiene susceptibility/resistance" RELATED []
is_a: GO:0017085 ! response to insecticide

[Term]
id: GO:0046683
name: response to organophosphorus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "organophosphorus resistance" RELATED []
synonym: "organophosphorus susceptibility/resistance" RELATED []
is_a: GO:0017085 ! response to insecticide

[Term]
id: GO:0046684
name: response to pyrethroid
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrethroid stimulus. Pyrethroids are a group of growth regulators, analogous to insect juvenile hormones, that interfere with the development of insect larvae and are used in the control of insects that are harmful in the adult stage." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "pyrethroid resistance" RELATED []
synonym: "pyrethroid susceptibility/resistance" RELATED []
is_a: GO:0017085 ! response to insecticide

[Term]
id: GO:0046685
name: response to arsenic
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:hjd, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "arsenate sensitivity/resistance" RELATED []
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0046686
name: response to cadmium ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:ai]
subset: gosubset_prok
synonym: "cadmium sensitivity/resistance" RELATED []
synonym: "response to cadmium" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0046687
name: response to chromate
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "chromate sensitivity/resistance" RELATED []
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0046688
name: response to copper ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:ai]
subset: gosubset_prok
synonym: "copper sensitivity/resistance" RELATED []
synonym: "response to copper" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0046689
name: response to mercury ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:ai]
subset: gosubset_prok
synonym: "mercuric sensitivity/resistance" RELATED []
synonym: "response to mercuric ion" NARROW [GOC:mah]
synonym: "response to mercury" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0046690
name: response to tellurium ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus." [GOC:ai]
subset: gosubset_prok
synonym: "response to tellurium" EXACT []
synonym: "tellurium sensitivity/resistance" RELATED []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0046691
name: intracellular canaliculus
namespace: cellular_component
def: "An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates." [GOC:mah, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:10700045]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0016324 ! apical plasma membrane

[Term]
id: GO:0046692
name: sperm competition
namespace: biological_process
def: "Any process that contributes to the success of sperm fertilization in multiply-mated females." [PMID:10885514]
xref: Wikipedia:Sperm_competition
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0007320 ! insemination

[Term]
id: GO:0046693
name: sperm storage
namespace: biological_process
def: "The retention of sperm by a female following mating." [PMID:10885514]
synonym: "retention of sperm" EXACT []
synonym: "sequestering of sperm" EXACT []
synonym: "sequestration of sperm" EXACT []
synonym: "sperm retention" EXACT []
synonym: "sperm sequestering" EXACT []
synonym: "sperm sequestration" EXACT []
synonym: "storage of sperm" EXACT []
is_a: GO:0046692 ! sperm competition

[Term]
id: GO:0046694
name: sperm incapacitation
namespace: biological_process
def: "The process by which the use of stored sperm from the first-mating male is inhibited by the seminal fluid of subsequently mating males." [PMID:10440373]
is_a: GO:0046692 ! sperm competition

[Term]
id: GO:0046695
name: SLIK (SAGA-like) complex
namespace: cellular_component
def: "A SAGA-type histone acetyltransferase complex that contains Rtg2 and a smaller form of Spt7 than the fungal SAGA complex, and lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction." [PMID:12101232, PMID:12186975, PMID:17337012]
comment: See also the cellular component term 'SAGA complex ; GO:0000124'.
synonym: "SAGA (alt) complex" EXACT []
synonym: "SALSA complex" EXACT []
synonym: "SLIK/SALSA complex" EXACT []
is_a: GO:0070461 ! SAGA-type complex

[Term]
id: GO:0046696
name: lipopolysaccharide receptor complex
namespace: cellular_component
def: "A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated." [PMID:11706042]
comment: Note that this term should not be used to refer to CD14 alone, but the multiprotein receptor complex that it is part of.
synonym: "LPS receptor complex" EXACT []
is_a: GO:0043235 ! receptor complex
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0016021 ! integral to membrane

[Term]
id: GO:0046697
name: decidualization
namespace: biological_process
def: "The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:11133685]
synonym: "decidual cell reaction" EXACT []
xref: Wikipedia:Decidualization
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0001893 ! maternal placenta development
relationship: part_of GO:0007565 ! female pregnancy

[Term]
id: GO:0046700
name: heterocycle catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai]
subset: gosubset_prok
synonym: "heterocycle breakdown" EXACT []
synonym: "heterocycle catabolism" EXACT []
synonym: "heterocycle degradation" EXACT []
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0046701
name: insecticide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects." [GOC:ai]
subset: gosubset_prok
synonym: "insecticide breakdown" EXACT []
synonym: "insecticide catabolism" EXACT []
synonym: "insecticide degradation" EXACT []
is_a: GO:0009407 ! toxin catabolic process
is_a: GO:0017143 ! insecticide metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0046702
name: galactoside 6-L-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside." [PMID:12413479]
is_a: GO:0046921 ! alpha(1,6)-fucosyltransferase activity

[Term]
id: GO:0046703
name: natural killer cell lectin-like receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lectin-like natural killer cell receptor." [GOC:ai]
synonym: "KLRC4 receptor binding" NARROW []
synonym: "NK cell lectin-like receptor binding" EXACT []
synonym: "NKG2D receptor binding" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0046704
name: CDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving CDP, cytidine (5'-)diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "CDP metabolism" EXACT []
is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process

[Term]
id: GO:0046705
name: CDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "CDP anabolism" EXACT []
synonym: "CDP biosynthesis" EXACT []
synonym: "CDP formation" EXACT []
synonym: "CDP synthesis" EXACT []
is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process
is_a: GO:0046704 ! CDP metabolic process

[Term]
id: GO:0046706
name: CDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of CDP, cytidine (5'-)diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "CDP breakdown" EXACT []
synonym: "CDP catabolism" EXACT []
synonym: "CDP degradation" EXACT []
is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process
is_a: GO:0046704 ! CDP metabolic process

[Term]
id: GO:0046707
name: IDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving IDP, inosine 5'-diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "IDP metabolism" EXACT []
is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process

[Term]
id: GO:0046708
name: IDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of IDP, inosine 5'-diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "IDP anabolism" EXACT []
synonym: "IDP biosynthesis" EXACT []
synonym: "IDP formation" EXACT []
synonym: "IDP synthesis" EXACT []
is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process
is_a: GO:0046707 ! IDP metabolic process

[Term]
id: GO:0046709
name: IDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "IDP breakdown" EXACT []
synonym: "IDP catabolism" EXACT []
synonym: "IDP degradation" EXACT []
is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process
is_a: GO:0046707 ! IDP metabolic process

[Term]
id: GO:0046710
name: GDP metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP metabolism" EXACT []
is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process

[Term]
id: GO:0046711
name: GDP biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of GDP, guanosine 5'-diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP anabolism" EXACT []
synonym: "GDP biosynthesis" EXACT []
synonym: "GDP formation" EXACT []
synonym: "GDP synthesis" EXACT []
is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process
is_a: GO:0046710 ! GDP metabolic process

[Term]
id: GO:0046712
name: GDP catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of GDP, guanosine 5'-diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "GDP breakdown" EXACT []
synonym: "GDP catabolism" EXACT []
synonym: "GDP degradation" EXACT []
is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process
is_a: GO:0046710 ! GDP metabolic process

[Term]
id: GO:0046713
name: boron transport
namespace: biological_process
def: "The directed movement of boron into, out of, within or between cells by means of some external agent such as a transporter or pore. Boron is a group 13 element, with properties which are borderline between metals and non-metals." [http://www.webelements.com/]
is_a: GO:0006810 ! transport

[Term]
id: GO:0046714
name: boron binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with boron, the group 13 element with properties which are borderline between metals and non-metals." [http://www.webelements.com/]
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0046715
name: boron transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transport of boron across a membrane against the concentration gradient." [PMID:12447444]
subset: gosubset_prok
synonym: "efflux-type boron transporter" NARROW []
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0046716
name: muscle homeostasis
namespace: biological_process
def: "The cellular homeostatic process by which a muscle fiber is preserved in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901]
synonym: "muscle fiber maintenance" EXACT [GOC:dph, GOC:tb]
is_a: GO:0019725 ! cellular homeostasis
is_a: GO:0060249 ! anatomical structure homeostasis

[Term]
id: GO:0046717
name: acid secretion
namespace: biological_process
def: "The controlled release of acid by a cell or group of cells." [GOC:ai]
is_a: GO:0046903 ! secretion

[Term]
id: GO:0046718
name: entry of virus into host cell
namespace: biological_process
def: "The process by which a virion enters a host cell, including virion attachment and penetration." [ISBN:0781718325]
synonym: "viral entry into host cell" EXACT []
xref: Reactome:168270 "Fusion and Uncoating of the Influenza Virion"
xref: Reactome:168272 "Binding of the influenza virion to the host cell"
is_a: GO:0030260 ! entry into host cell
relationship: part_of GO:0019059 ! initiation of viral infection

[Term]
id: GO:0046719
name: regulation of viral protein levels in host cell
namespace: biological_process
def: "Any virus-mediated process that modulates the levels of viral proteins in a cell." [GOC:ai]
synonym: "regulation of viral protein levels" EXACT []
is_a: GO:0019048 ! virus-host interaction
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0046720
name: citric acid secretion
namespace: biological_process
def: "The controlled release of citric acid, 2-hydroxy-1,2,3-propanetricarboxylic acid, by a cell or group of cells." [GOC:ai]
synonym: "citrate secretion" EXACT []
is_a: GO:0006842 ! tricarboxylic acid transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0046721
name: formic acid secretion
namespace: biological_process
def: "The controlled release of formic acid, HCOOH, by a cell or group of cells." [GOC:ai]
synonym: "formate secretion" EXACT []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0046722
name: lactic acid secretion
namespace: biological_process
def: "The controlled release of lactic acid, 2-hydroxypropanoic acid, by a cell or group of cells." [GOC:ai]
synonym: "lactate secretion" EXACT []
is_a: GO:0015718 ! monocarboxylic acid transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0046723
name: malic acid secretion
namespace: biological_process
def: "The controlled release of malic acid, hydroxybutanedioic (hydroxysuccinic) acid, by a cell or group of cells." [GOC:ai]
synonym: "hydroxysuccinic acid secretion" EXACT []
synonym: "malate secretion" EXACT []
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0046724
name: oxalic acid secretion
namespace: biological_process
def: "The controlled release of oxalic acid, ethanedioic acid, by a cell or group of cells." [GOC:ai]
synonym: "oxalate secretion" EXACT []
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0046725
name: negative regulation of viral protein levels in host cell
namespace: biological_process
def: "Any process that reduces the levels of viral proteins in a cell." [GOC:ai]
synonym: "down regulation of viral protein levels in host cell" EXACT []
synonym: "down-regulation of viral protein levels in host cell" EXACT []
synonym: "downregulation of viral protein levels in host cell" EXACT []
synonym: "inhibition of viral protein levels in host cell" NARROW []
synonym: "negative regulation of viral protein levels" EXACT []
is_a: GO:0046719 ! regulation of viral protein levels in host cell
is_a: GO:0048519 ! negative regulation of biological process

[Term]
id: GO:0046726
name: positive regulation of viral protein levels in host cell
namespace: biological_process
def: "Any process that increases the levels of viral proteins in a cell." [GOC:ai]
synonym: "activation of viral protein levels in host cell" NARROW []
synonym: "positive regulation of viral protein levels" EXACT []
synonym: "stimulation of viral protein levels in host cell" NARROW []
synonym: "up regulation of viral protein levels in host cell" EXACT []
synonym: "up-regulation of viral protein levels in host cell" EXACT []
synonym: "upregulation of viral protein levels in host cell" EXACT []
is_a: GO:0046719 ! regulation of viral protein levels in host cell
is_a: GO:0048518 ! positive regulation of biological process

[Term]
id: GO:0046727
name: capsomere
namespace: cellular_component
def: "Any of the protein subunits that comprise the closed shell or coat (capsid) of certain viruses." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "capsomer" EXACT []
xref: Wikipedia:Capsomere
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019028 ! viral capsid

[Term]
id: GO:0046729
name: viral procapsid
namespace: cellular_component
def: "A stable empty viral capsid produced during the assembly of viruses." [ISBN:0072370319, ISBN:1555811272]
is_a: GO:0044423 ! virion part

[Term]
id: GO:0046730
name: induction of host immune response by virus
namespace: biological_process
def: "The induction by a virus of an immune response in the host organism." [ISBN:0781802976]
synonym: "activation of host immune response by virus" EXACT []
is_a: GO:0019048 ! virus-host interaction
is_a: GO:0044416 ! induction by symbiont of host defense response

[Term]
id: GO:0046731
name: passive induction of host immune response by virus
namespace: biological_process
def: "The unintentional stimulation by a virus of a host defense response to viral infection, as part of the viral infectious cycle." [ISBN:0781802976]
synonym: "passive activation of host immune response by virus" EXACT []
synonym: "passive viral induction of host immune response" EXACT []
is_a: GO:0046730 ! induction of host immune response by virus

[Term]
id: GO:0046732
name: active induction of host immune response by virus
namespace: biological_process
def: "The intentional, virally-encoded stimulation of a host defense response to viral infection." [ISBN:0781802976]
synonym: "active viral induction of host immune response" EXACT []
xref: Reactome:168277 "Influenza Virus Induced Apoptosis"
xref: Reactome:168865 "NA activation of TGF-beta"
xref: Reactome:168878 "PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis"
is_a: GO:0046730 ! induction of host immune response by virus

[Term]
id: GO:0046733
name: passive induction of host humoral immune response by virus
namespace: biological_process
def: "The unintentional stimulation by a virus of a host humoral defense response to viral infection, as part of the viral infectious cycle." [ISBN:0781802976]
synonym: "passive induction of humoral immune response in host by virus" EXACT []
synonym: "passive viral activation of humoral immune response in host" EXACT []
synonym: "passive viral induction of humoral immune response in host" EXACT []
is_a: GO:0046731 ! passive induction of host immune response by virus

[Term]
id: GO:0046734
name: passive induction of host cell-mediated immune response by virus
namespace: biological_process
def: "The unintentional stimulation by a virus of a cell-mediated host defense response to viral infection, as part of the viral infectious cycle." [ISBN:0781802976]
synonym: "passive induction of cell-mediated immune response in host by virus" EXACT []
synonym: "passive viral activation of cell-mediated immune response in host" EXACT []
synonym: "passive viral induction of cell-mediated immune response in host" EXACT []
is_a: GO:0046731 ! passive induction of host immune response by virus

[Term]
id: GO:0046735
name: passive induction of host innate immune response by virus
namespace: biological_process
def: "The unintentional stimulation by a virus of an innate host defense response to viral infection, as part of the viral infectious cycle." [GOC:go_curators, ISBN:0781802976]
synonym: "passive induction of innate immune response in host by virus" EXACT []
synonym: "passive viral activation of innate immune response in host" EXACT []
synonym: "passive viral induction of innate immune response in host" EXACT []
is_a: GO:0046731 ! passive induction of host immune response by virus

[Term]
id: GO:0046736
name: active induction of humoral immune response in host by virus
namespace: biological_process
def: "The intentional, virally-encoded stimulation of a host humoral defense response to viral infection." [ISBN:0781802976]
synonym: "active viral induction of humoral immune response in host" EXACT []
is_a: GO:0046732 ! active induction of host immune response by virus

[Term]
id: GO:0046737
name: active induction of cell-mediated immune response in host by virus
namespace: biological_process
def: "The intentional, virally-encoded stimulation of a cell-mediated host defense response to viral infection." [ISBN:0781802976]
synonym: "active viral induction of cell-mediated immune response in host" EXACT []
is_a: GO:0046732 ! active induction of host immune response by virus

[Term]
id: GO:0046738
name: active induction of innate immune response in host by virus
namespace: biological_process
def: "The intentional, virally-encoded stimulation of an innate host defense response to viral infection." [ISBN:0781802976]
synonym: "active viral induction of innate immune response in host" EXACT []
is_a: GO:0046732 ! active induction of host immune response by virus

[Term]
id: GO:0046739
name: spread of virus in host
namespace: biological_process
def: "The dissemination of infectious virion particles within an infected host organism." [ISBN:0781718325]
synonym: "spread of virus within host" EXACT []
synonym: "viral spread within host" EXACT []
is_a: GO:0019048 ! virus-host interaction
is_a: GO:0044000 ! movement in host

[Term]
id: GO:0046740
name: spread of virus in host, cell to cell
namespace: biological_process
def: "The process of viral dissemination within an infected host organism where infectious virion particles are passed from infected to uninfected host cells." [ISBN:0781718325]
synonym: "cell to cell spread of virus within host" EXACT []
synonym: "spread of virus within host, cell to cell" EXACT []
synonym: "viral spread within host, cell to cell" EXACT []
is_a: GO:0046739 ! spread of virus in host

[Term]
id: GO:0046741
name: spread of virus in host, tissue to tissue
namespace: biological_process
def: "The process of viral dissemination within an infected host organism where infectious virion particles are passed from infected to uninfected host tissue." [ISBN:0781718325]
synonym: "spread of virus within host, tissue to tissue" EXACT []
synonym: "tissue to tissue spread of virus within host" EXACT []
synonym: "viral spread within host, tissue to tissue" EXACT []
is_a: GO:0046739 ! spread of virus in host

[Term]
id: GO:0046742
name: viral capsid transport in host cell nucleus
namespace: biological_process
def: "The directed movement of viral capsid proteins within the nucleus of the host cell." [ISBN:0781718325]
synonym: "nuclear viral capsid transport" EXACT []
is_a: GO:0046801 ! intracellular transport of viral capsid in host cell

[Term]
id: GO:0046743
name: viral capsid transport in host cell cytoplasm
namespace: biological_process
def: "The directed movement of viral capsid proteins within the cytoplasm of the host cell." [ISBN:0781718325, PMID:11581394]
synonym: "cytoplasmic viral capsid transport" EXACT []
is_a: GO:0016482 ! cytoplasmic transport
is_a: GO:0046801 ! intracellular transport of viral capsid in host cell

[Term]
id: GO:0046744
name: viral capsid envelopment
namespace: biological_process
def: "The process by which a capsid acquires a membrane envelope." [ISBN:0781718325]
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019069 ! viral capsid assembly

[Term]
id: GO:0046745
name: viral capsid re-envelopment
namespace: biological_process
def: "The process by which a capsid acquires another membrane envelope, subsequent to acquiring an initial membrane envelope." [ISBN:0781718325]
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019069 ! viral capsid assembly

[Term]
id: GO:0046746
name: virus budding from nuclear membrane during viral capsid re-envelopment
namespace: biological_process
def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host nuclear membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319]
synonym: "nuclear membrane viral budding during viral capsid re-envelopment" EXACT []
synonym: "viral budding from nuclear membrane during viral capsid re-envelopment" EXACT []
is_a: GO:0046745 ! viral capsid re-envelopment
is_a: GO:0046765 ! virus budding from nuclear membrane

[Term]
id: GO:0046747
name: virus budding from Golgi membrane during viral capsid re-envelopment
namespace: biological_process
def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host Golgi membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319]
synonym: "Golgi membrane viral budding during viral capsid re-envelopment" EXACT []
synonym: "viral budding from Golgi membrane during viral capsid re-envelopment" EXACT []
is_a: GO:0046745 ! viral capsid re-envelopment
is_a: GO:0046763 ! virus budding from Golgi membrane

[Term]
id: GO:0046748
name: virus budding from ER membrane during viral capsid re-envelopment
namespace: biological_process
def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319]
synonym: "endoplasmic reticulum membrane viral budding during viral capsid re-envelopment" EXACT []
synonym: "ER membrane viral budding during viral capsid re-envelopment" EXACT []
synonym: "viral budding from ER membrane during viral capsid re-envelopment" EXACT []
is_a: GO:0046745 ! viral capsid re-envelopment
is_a: GO:0046764 ! virus budding from ER membrane

[Term]
id: GO:0046749
name: virus budding from nuclear membrane during viral capsid envelopment
namespace: biological_process
def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host nuclear membrane system, thus acquiring a membrane envelope." [ISBN:0072370319]
synonym: "nuclear membrane viral budding during viral capsid envelopment" EXACT []
synonym: "viral budding from nuclear membrane during viral capsid envelopment" EXACT []
is_a: GO:0046744 ! viral capsid envelopment
is_a: GO:0046765 ! virus budding from nuclear membrane

[Term]
id: GO:0046750
name: virus budding from Golgi membrane during viral capsid envelopment
namespace: biological_process
def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host Golgi membrane system, thus acquiring a membrane envelope." [ISBN:0072370319]
synonym: "Golgi membrane viral budding during viral capsid envelopment" EXACT []
synonym: "viral budding from Golgi membrane during viral capsid envelopment" EXACT []
is_a: GO:0046744 ! viral capsid envelopment
is_a: GO:0046763 ! virus budding from Golgi membrane

[Term]
id: GO:0046751
name: virus budding from ER membrane during viral capsid envelopment
namespace: biological_process
def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, thus acquiring a membrane envelope." [ISBN:0072370319]
synonym: "endoplasmic reticulum membrane viral budding during viral capsid envelopment" EXACT []
synonym: "ER membrane viral budding during viral capsid envelopment" EXACT []
synonym: "viral budding from ER membrane during viral capsid envelopment" EXACT []
is_a: GO:0046744 ! viral capsid envelopment
is_a: GO:0046764 ! virus budding from ER membrane

[Term]
id: GO:0046752
name: viral capsid precursor localization in host cell nucleus
namespace: biological_process
def: "Any process by which viral capsid precursors are transported to, or maintained in, a specific location in the nucleus, thus accumulating the necessary components for assembly of a capsid." [ISBN:0781718325]
synonym: "establishment and maintenance of viral capsid precursor localization in nucleus" EXACT []
synonym: "localization of viral capsid precursors in nucleus" EXACT []
synonym: "nuclear localization of viral capsid precursors" EXACT []
is_a: GO:0008104 ! protein localization
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019069 ! viral capsid assembly
relationship: part_of GO:0046719 ! regulation of viral protein levels in host cell

[Term]
id: GO:0046753
name: non-lytic viral release
namespace: biological_process
def: "The release of virion particles from the cell that does not result in cell lysis." [ISBN:0072370319]
is_a: GO:0019076 ! release of virus from host

[Term]
id: GO:0046754
name: non-lytic viral exocytosis
namespace: biological_process
def: "The exit of the virion particle from the host cell by exocytosis, without causing cell lysis." [ISBN:0072370319]
is_a: GO:0046753 ! non-lytic viral release

[Term]
id: GO:0046755
name: non-lytic virus budding
namespace: biological_process
def: "A form of viral release in which the viral particles bud out through cellular membranes without causing cell lysis. It is also a form of viral envelopment." [ISBN:0072370319]
synonym: "non-lytic viral budding" EXACT []
is_a: GO:0046753 ! non-lytic viral release

[Term]
id: GO:0046756
name: lytic viral exocytosis
namespace: biological_process
def: "The exit of the virion particle from the host cell by exocytosis, resulting in cell lysis." [ISBN:0072370319]
is_a: GO:0019077 ! lytic viral release

[Term]
id: GO:0046757
name: lytic virus budding from ER membrane
namespace: biological_process
def: "A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319]
synonym: "lytic endoplasmic reticulum membrane viral budding" EXACT []
synonym: "lytic ER membrane viral budding" EXACT []
synonym: "lytic viral budding from ER membrane" EXACT []
is_a: GO:0019078 ! lytic viral budding
is_a: GO:0046764 ! virus budding from ER membrane

[Term]
id: GO:0046758
name: lytic virus budding from Golgi membrane
namespace: biological_process
def: "A form of viral release in which the nucleocapsid evaginates from the host Golgi membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319]
synonym: "lytic Golgi membrane viral budding" EXACT []
synonym: "lytic viral budding from Golgi membrane" EXACT []
is_a: GO:0019078 ! lytic viral budding
is_a: GO:0046763 ! virus budding from Golgi membrane

[Term]
id: GO:0046759
name: lytic virus budding from plasma membrane
namespace: biological_process
def: "A form of viral release in which the nucleocapsid evaginates from the host nuclear membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319]
synonym: "lytic plasma membrane viral budding" EXACT []
synonym: "lytic viral budding from plasma membrane" EXACT []
is_a: GO:0019078 ! lytic viral budding
is_a: GO:0046766 ! virus budding from plasma membrane

[Term]
id: GO:0046760
name: non-lytic virus budding from Golgi membrane
namespace: biological_process
def: "A form of viral release in which the nucleocapsid evaginates from the host Golgi membrane system, resulting in envelopment of the virus without triggering cell lysis." [ISBN:0072370319]
synonym: "non-lytic Golgi membrane viral budding" EXACT []
synonym: "non-lytic viral budding from Golgi membrane" EXACT []
is_a: GO:0046755 ! non-lytic virus budding
is_a: GO:0046763 ! virus budding from Golgi membrane

[Term]
id: GO:0046761
name: non-lytic virus budding from plasma membrane
namespace: biological_process
def: "A form of viral release in which the nucleocapsid evaginates from the host plasma membrane system, resulting in envelopment of the virus without triggering cell lysis." [ISBN:0072370319]
synonym: "non-lytic plasma membrane viral budding" EXACT []
synonym: "non-lytic viral budding from plasma membrane" EXACT []
is_a: GO:0046755 ! non-lytic virus budding
is_a: GO:0046766 ! virus budding from plasma membrane

[Term]
id: GO:0046762
name: non-lytic virus budding from ER membrane
namespace: biological_process
def: "A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus without triggering cell lysis." [ISBN:0072370319]
synonym: "non-lytic endoplasmic reticulum membrane viral budding" EXACT []
synonym: "non-lytic ER membrane viral budding" EXACT []
synonym: "non-lytic viral budding from ER membrane" EXACT []
is_a: GO:0046755 ! non-lytic virus budding
is_a: GO:0046764 ! virus budding from ER membrane

[Term]
id: GO:0046763
name: virus budding from Golgi membrane
namespace: biological_process
def: "The evagination of the nucleocapsid from the host Golgi membrane system, resulting in envelopment of the virus." [ISBN:0072370319]
synonym: "Golgi membrane viral budding" EXACT []
synonym: "viral budding from Golgi membrane" EXACT []
is_a: GO:0019067 ! viral assembly, maturation, egress, and release

[Term]
id: GO:0046764
name: virus budding from ER membrane
namespace: biological_process
def: "The evagination of the nucleocapsid from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus." [ISBN:0072370319]
synonym: "endoplasmic reticulum membrane viral budding" EXACT []
synonym: "ER membrane viral budding" EXACT []
synonym: "viral budding from ER membrane" EXACT []
is_a: GO:0019067 ! viral assembly, maturation, egress, and release

[Term]
id: GO:0046765
name: virus budding from nuclear membrane
namespace: biological_process
def: "The evagination of the nucleocapsid from the host nuclear membrane system, resulting in envelopment of the virus." [ISBN:0072370319]
synonym: "nuclear membrane viral budding" EXACT []
synonym: "viral budding from nuclear membrane" EXACT []
is_a: GO:0019067 ! viral assembly, maturation, egress, and release

[Term]
id: GO:0046766
name: virus budding from plasma membrane
namespace: biological_process
def: "The evagination of the nucleocapsid from the host plasma membrane system, resulting in envelopment of the virus." [ISBN:0072370319]
synonym: "plasma membrane viral budding" EXACT []
synonym: "viral budding from plasma membrane" EXACT []
xref: Reactome:168860 "Membrane fusion"
is_a: GO:0019067 ! viral assembly, maturation, egress, and release

[Term]
id: GO:0046767
name: virus budding from plasma membrane during viral capsid envelopment
namespace: biological_process
def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host plasma membrane system, thus acquiring a membrane envelope." [ISBN:0072370319]
synonym: "plasma membrane viral budding during viral capsid envelopment" EXACT []
synonym: "viral budding from plasma membrane during viral capsid envelopment" EXACT []
is_a: GO:0046744 ! viral capsid envelopment
is_a: GO:0046766 ! virus budding from plasma membrane

[Term]
id: GO:0046768
name: virus budding from plasma membrane during viral capsid re-envelopment
namespace: biological_process
def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host plasma membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319]
synonym: "plasma membrane viral budding during viral capsid re-envelopment" EXACT []
synonym: "viral budding from plasma membrane during viral capsid re-envelopment" EXACT []
is_a: GO:0046745 ! viral capsid re-envelopment
is_a: GO:0046766 ! virus budding from plasma membrane

[Term]
id: GO:0046769
name: virus budding from inner nuclear membrane during viral capsid re-envelopment
namespace: biological_process
def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host inner nuclear membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319]
synonym: "inner nuclear membrane viral budding during viral capsid re-envelopment" EXACT []
synonym: "viral budding from inner nuclear membrane during viral capsid re-envelopment" EXACT []
is_a: GO:0046746 ! virus budding from nuclear membrane during viral capsid re-envelopment

[Term]
id: GO:0046770
name: virus budding from outer nuclear membrane during viral capsid re-envelopment
namespace: biological_process
def: "The re-envelopment of a virus, in which the nucleocapsid evaginates from the host outer nuclear membrane system, thus acquiring an additional membrane envelope." [ISBN:0072370319]
synonym: "outer nuclear membrane viral budding during viral capsid re-envelopment" EXACT []
synonym: "viral budding from outer nuclear membrane during viral capsid re-envelopment" EXACT []
is_a: GO:0046746 ! virus budding from nuclear membrane during viral capsid re-envelopment

[Term]
id: GO:0046771
name: virus budding from inner nuclear membrane during viral capsid envelopment
namespace: biological_process
def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host inner nuclear membrane system, thus acquiring a membrane envelope." [ISBN:0072370319]
synonym: "inner nuclear membrane viral budding during viral capsid envelopment" EXACT []
synonym: "viral budding from inner nuclear membrane during viral capsid envelopment" EXACT []
is_a: GO:0046749 ! virus budding from nuclear membrane during viral capsid envelopment

[Term]
id: GO:0046772
name: virus budding from outer nuclear membrane during viral capsid envelopment
namespace: biological_process
def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host outer nuclear membrane system, thus acquiring a membrane envelope." [ISBN:0072370319]
synonym: "outer nuclear membrane viral budding during viral capsid envelopment" EXACT []
synonym: "viral budding from outer nuclear membrane during viral capsid envelopment" EXACT []
is_a: GO:0046749 ! virus budding from nuclear membrane during viral capsid envelopment

[Term]
id: GO:0046773
name: suppression by virus of host termination of protein biosynthetic process
namespace: biological_process
def: "Any viral process that inhibits the termination of host cell protein biosynthesis that occurs in response to viral infection." [ISBN:0781718325]
synonym: "negative regulation by virus of host cell protein biosynthesis shutoff" EXACT []
synonym: "negative regulation by virus of host cell protein biosynthetic process shutoff" EXACT []
synonym: "viral inhibition of host cell protein biosynthesis shutoff" EXACT []
synonym: "viral inhibition of host cell protein biosynthetic process shutoff" EXACT []
synonym: "viral inhibition of termination of host cell protein biosynthesis" EXACT []
synonym: "viral inhibition of termination of host cell protein biosynthetic process" EXACT []
synonym: "viral suppression of termination by host of host cell protein biosynthesis" EXACT []
synonym: "viral suppression of termination by host of host cell protein biosynthetic process" EXACT []
is_a: GO:0019049 ! evasion of host defenses by virus
is_a: GO:0019054 ! modulation by virus of host cellular process

[Term]
id: GO:0046774
name: suppression by virus of host intracellular interferon activity
namespace: biological_process
def: "Any viral process that results in the inhibition of interferon activity within the host cell." [PMID:10859382]
synonym: "negative regulation by virus of intracellular interferon activity" EXACT []
synonym: "suppression by virus of intracellular interferon activity in host" EXACT []
is_a: GO:0019052 ! suppression by virus of host intracellular antiviral response

[Term]
id: GO:0046775
name: suppression by virus of host cytokine production
namespace: biological_process
def: "Any viral process that results in the inhibition of host cell cytokine production." [PMID:10859382]
synonym: "negative regulation by virus of host cytokine production" EXACT []
is_a: GO:0019052 ! suppression by virus of host intracellular antiviral response
is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response

[Term]
id: GO:0046776
name: suppression by virus of host MHC class I cell surface presentation
namespace: biological_process
def: "Any viral process that results in the inhibition of presentation of MHC class I antigen-presenting proteins on the host cell surface." [PMID:10859382]
synonym: "major histocompatibility complex" RELATED []
synonym: "negative regulation by virus of MHC class I cell surface presentation" EXACT []
synonym: "suppression by virus of MHC class I cell surface presentation in host" EXACT []
is_a: GO:0019052 ! suppression by virus of host intracellular antiviral response

[Term]
id: GO:0046777
name: protein amino acid autophosphorylation
namespace: biological_process
def: "The phosphorylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
xref: Reactome:441139 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes"
xref: Reactome:462961 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes"
xref: Reactome:481662 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes"
xref: Reactome:501830 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes"
xref: Reactome:514582 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes"
xref: Reactome:523614 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes"
xref: Reactome:529764 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes"
xref: Reactome:535023 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes"
xref: Reactome:540626 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes"
xref: Reactome:546253 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes"
xref: Reactome:556203 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes"
xref: Reactome:565868 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes"
xref: Reactome:578588 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes"
xref: Reactome:584740 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes"
xref: Reactome:75147 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes"
is_a: GO:0006468 ! protein amino acid phosphorylation

[Term]
id: GO:0046778
name: modification by virus of host mRNA processing
namespace: biological_process
def: "Any viral process that interferes with the processing of mRNA in the host cell." [ISBN:0781718325]
synonym: "viral perturbation of host mRNA processing" EXACT []
xref: Reactome:168315 "Inhibition of Host mRNA Processing and RNA Silencing"
xref: Reactome:168859 "Binding of NS1 to cleavage and host polyadenylation specificity factor (CPSF)"
xref: Reactome:168883 "Binding of NS1 to poly(A)-binding protein II (PABII)"
is_a: GO:0019056 ! modulation by virus of host transcription

[Term]
id: GO:0046779
name: suppression by virus of expression of host genes with introns
namespace: biological_process
def: "Any viral process that discriminates against and subsequently inhibits host transcripts containing introns, thus allowing only intronless viral mRNA to be fully processed." [PMID:11598019]
synonym: "negative regulation by virus of expression of host genes with introns" EXACT []
synonym: "viral inhibition of expression of host genes with introns" EXACT []
is_a: GO:0019056 ! modulation by virus of host transcription

[Term]
id: GO:0046780
name: suppression by virus of host mRNA splicing
namespace: biological_process
def: "Any viral process that inhibits the splicing of host mRNA, thus reducing host protein production." [ISBN:0781718325]
synonym: "negative regulation by virus of host mRNA splicing" EXACT []
synonym: "viral inhibition of host mRNA splicing" EXACT []
is_a: GO:0046778 ! modification by virus of host mRNA processing

[Term]
id: GO:0046781
name: dispersion by virus of host splicing factors
namespace: biological_process
def: "Any viral process that disperses host splicing factors (snRNPs) to prevent host mRNA splicing, thus reducing host protein production." [ISBN:0781718325]
synonym: "viral dispersion of host splicing factors" EXACT []
is_a: GO:0046778 ! modification by virus of host mRNA processing

[Term]
id: GO:0046782
name: regulation of viral transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the transcription of the viral genome." [GOC:ai]
is_a: GO:0045449 ! regulation of transcription
is_a: GO:0050792 ! regulation of viral reproduction
relationship: regulates GO:0019083 ! viral transcription

[Term]
id: GO:0046783
name: modification by virus of host polysomes
namespace: biological_process
def: "Any viral process that interferes with and inhibits the assembly and function of polysomes." [PMID:10438802]
comment: See also the cellular component term 'polysome ; GO:0005844'.
synonym: "viral perturbation of polysomes" EXACT []
is_a: GO:0019057 ! modulation of host translation by virus

[Term]
id: GO:0046784
name: intronless viral mRNA export from host nucleus
namespace: biological_process
def: "The directed movement of intronless viral mRNA from the host nucleus to the cytoplasm for translation." [PMID:11598019]
synonym: "intronless viral mRNA export from host cell nucleus" EXACT []
synonym: "intronless viral mRNA export out of nucleus" EXACT []
synonym: "intronless viral mRNA transport from nucleus to cytoplasm" EXACT []
synonym: "intronless viral mRNA-nucleus export" EXACT []
is_a: GO:0006406 ! mRNA export from nucleus
is_a: GO:0019048 ! virus-host interaction

[Term]
id: GO:0046785
name: microtubule polymerization
namespace: biological_process
def: "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai]
is_a: GO:0031109 ! microtubule polymerization or depolymerization
is_a: GO:0051258 ! protein polymerization

[Term]
id: GO:0046786
name: viral replication complex formation and maintenance
namespace: biological_process
def: "The process of organizing and assembling viral replication proteins in preparation for viral replication." [ISBN:0781718325]
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019079 ! viral genome replication

[Term]
id: GO:0046787
name: viral DNA repair
namespace: biological_process
def: "The process of restoring viral DNA after damage or errors in replication." [ISBN:0781718325]
is_a: GO:0006281 ! DNA repair
relationship: part_of GO:0019079 ! viral genome replication

[Term]
id: GO:0046788
name: egress of virus within host cell
namespace: biological_process
def: "The process of moving the (often) incomplete virion to the cell surface in order to be released from the cell. Egress can involve travel through the endoplasmic reticulum or cytoplasm and will often include final maturation stages of the virion, but it occurs entirely within the cell." [GOC:rh1, ISBN:0781718325]
synonym: "movement of virus within host cell" EXACT []
synonym: "viral egress" EXACT []
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019067 ! viral assembly, maturation, egress, and release

[Term]
id: GO:0046789
name: host cell surface receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor on the host cell surface." [GOC:ai, PMID:11511370]
subset: gosubset_prok
synonym: "cell surface antigen activity, host-interacting" RELATED []
synonym: "cell surface receptor ligand" RELATED []
is_a: GO:0005102 ! receptor binding
is_a: GO:0046812 ! host cell surface binding

[Term]
id: GO:0046790
name: virion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a virion, either by binding to components of the capsid or the viral envelope." [GOC:ai]
is_a: GO:0005488 ! binding

[Term]
id: GO:0046791
name: suppression by virus of host complement neutralization
namespace: biological_process
def: "Any viral process that results in the inhibition of complement neutralization of the host cell." [PMID:10587354]
synonym: "negative regulation by virus of host complement neutralization" EXACT []
is_a: GO:0019053 ! suppression by virus of host extracellular antiviral response

[Term]
id: GO:0046792
name: suppression by virus of host cell cycle arrest
namespace: biological_process
def: "Viral interference in host cell processes that lead cell cycle arrest, allowing cell division to occur." [PMID:9371605]
synonym: "negative regulation by virus of cell cycle arrest" EXACT []
synonym: "viral inhibition of cell cycle arrest" EXACT []
is_a: GO:0019055 ! modification by virus of host cell cycle regulation

[Term]
id: GO:0046793
name: induction by virus of modification of host RNA polymerase II
namespace: biological_process
def: "The viral induction of modification to the host RNA polymerase II." [PMID:7637000]
synonym: "virus-induced modification of host RNA polymerase II" EXACT []
is_a: GO:0019056 ! modulation by virus of host transcription

[Term]
id: GO:0046794
name: virion transport
namespace: biological_process
def: "The directed movement of a virion into, out of, or within a host cell." [GOC:ai]
subset: goslim_pir
is_a: GO:0006810 ! transport
is_a: GO:0019048 ! virus-host interaction

[Term]
id: GO:0046795
name: intracellular virion transport
namespace: biological_process
def: "The directed movement of a virion within a host cell from one location to another." [GOC:ai, PMID:11733033]
is_a: GO:0046794 ! virion transport
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0046796
name: viral genome transport in host cell
namespace: biological_process
def: "The directed movement of the viral genome(s) within a host cell." [GOC:ai, PMID:11090159]
xref: Reactome:168271 "Transport of Ribonucleoproteins into the Host Nucleus"
xref: Reactome:168274 "Export of Viral Ribonucleoproteins from Nucleus"
xref: Reactome:168297 "Recognition of the Nuclear Localization Signal (NLS) by a Karyopherin Alpha Family Protein"
xref: Reactome:168310 "Release of the RNP into the host cell nucleus"
xref: Reactome:168317 "Recruitment of Karyopherin Beta to form a Trimeric Complex"
xref: Reactome:168333 "NEP/NS2 Interacts with the Cellular Export Machinery"
xref: Reactome:168337 "Docking and transport of the RNP:Karyopherin complex through the nuclear pore"
xref: Reactome:168857 "Binding of vRNP:M1:NEP complex to CRM1 export receptor"
xref: Reactome:168880 "vRNP Export through the nuclear pore"
xref: Reactome:168893 "Binding of NEP/NS2 to vRNP:M1"
xref: Reactome:168984 "Export through the nuclear pore"
is_a: GO:0006810 ! transport
is_a: GO:0019048 ! virus-host interaction

[Term]
id: GO:0046797
name: viral procapsid maturation
namespace: biological_process
def: "The period of virion development during which the capsid components form the immature capsid and encapsulate the viral genome; the capsid often undergoes a number of structural alterations during this period." [PMID:10627558]
is_a: GO:0021700 ! developmental maturation
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019069 ! viral capsid assembly

[Term]
id: GO:0046798
name: viral portal complex
namespace: cellular_component
def: "A multimeric ring of proteins through which the DNA enters and exits the viral capsid." [PMID:11602732]
is_a: GO:0043234 ! protein complex
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019028 ! viral capsid

[Term]
id: GO:0046799
name: recruitment of helicase-primase complex to DNA lesions
namespace: biological_process
def: "The recruitment of the helicase-primase complex to viral DNA lesions during viral DNA repair." [ISBN:0781718325]
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0046787 ! viral DNA repair

[Term]
id: GO:0046800
name: enhancement of virulence
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the severity of viral infection and subsequent disease." [PMID:10587354]
comment: This term was made obsolete because 'virulence' is not a biological process; however, alteration of virulence also does not fit under 'regulation of biological quality ; GO:0065008' because it is a product both of the genotype/phenotype of the infecting organism and the genotype/phenotype of the organism being infected and varies by individual within a species both for the infecting organism and the infected organism.
is_obsolete: true

[Term]
id: GO:0046801
name: intracellular transport of viral capsid in host cell
namespace: biological_process
def: "The directed movement of viral capsid proteins within the host cell." [GOC:ai, PMID:9188566]
synonym: "intracellular viral capsid transport" EXACT []
is_a: GO:0019060 ! intracellular transport of viral proteins in host cell
relationship: part_of GO:0019069 ! viral capsid assembly

[Term]
id: GO:0046802
name: egress of viral procapsid from host cell nucleus
namespace: biological_process
def: "The exit of the immature viral procapsid from the nucleus of the host cell." [PMID:9601512, PMID:9765421]
synonym: "nuclear egress of viral procapsid" EXACT []
is_a: GO:0006913 ! nucleocytoplasmic transport
is_a: GO:0046801 ! intracellular transport of viral capsid in host cell

[Term]
id: GO:0046803
name: reduction of virulence
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the severity of viral infection and subsequent disease." [PMID:10982346]
comment: This term was made obsolete because 'virulence' is not a biological process; however, alteration of virulence also does not fit under 'regulation of biological quality ; GO:0065008' because it is a product both of the genotype/phenotype of the infecting organism and the genotype/phenotype of the organism being infected and varies by individual within a species both for the infecting organism and the infected organism.
is_obsolete: true

[Term]
id: GO:0046804
name: peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide
namespace: biological_process
def: "The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide (3-methyl-L-lanthionine sulfoxide), as found in the antibiotic actagardine." [RESID:AA0330]
subset: gosubset_prok
synonym: "peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulphoxide" EXACT []
xref: RESID:AA0330
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0046805
name: protein-heme linkage via 1'-L-histidine
namespace: biological_process
def: "The covalent linkage of heme and a protein via 1'-L-histidine (otherwise known as tau-heme-histidine, tele-heme-histidine)." [RESID:AA0329]
subset: gosubset_prok
synonym: "protein-haem linkage via 1'-L-histidine" EXACT []
xref: RESID:AA0329
is_a: GO:0017003 ! protein-heme linkage
is_a: GO:0017004 ! cytochrome complex assembly

[Term]
id: GO:0046806
name: viral scaffold
namespace: cellular_component
def: "A complex of proteins that form a scaffold around which the viral capsid is constructed." [ISBN:0072370319]
is_a: GO:0043234 ! protein complex
is_a: GO:0044423 ! virion part
relationship: part_of GO:0019028 ! viral capsid

[Term]
id: GO:0046807
name: viral scaffold assembly and maintenance
namespace: biological_process
def: "The assembly and maintenance of the viral scaffold around which the viral capsid is constructed." [ISBN:0072370319]
comment: See also the cellular component term 'viral scaffold ; GO:0046806'.
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019069 ! viral capsid assembly

[Term]
id: GO:0046808
name: assemblon
namespace: cellular_component
def: "Antigenically dense structures located at the periphery of nuclei, close to but not abutting nuclear membranes. Assemblons contain the proteins for immature-capsid assembly; they are located at the periphery of a diffuse structure composed of proteins involved in DNA synthesis, which overlaps only minimally with the assemblons. More than one site can be present simultaneously." [PMID:8676489]
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0046809
name: replication compartment
namespace: cellular_component
def: "Globular nuclear domains where the transcription and replication of the viral genome occurs. More than one site can be present simultaneously." [PMID:9499108]
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0046810
name: host cell extracellular matrix binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the extracellular matrix of a host cell." [PMID:7996163]
subset: gosubset_prok
is_a: GO:0050840 ! extracellular matrix binding

[Term]
id: GO:0046811
name: histone deacetylase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes." [GOC:ai, PMID:10482575]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0035033 ! histone deacetylase regulator activity

[Term]
id: GO:0046812
name: host cell surface binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the surface of a host cell." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0046813
name: virion attachment, binding of host cell surface receptor
namespace: biological_process
def: "The process during virion attachment where a virion binds to a host cell receptor, resulting in a conformational change of the virus protein." [ISBN:0879694971]
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019062 ! virion attachment to host cell surface receptor

[Term]
id: GO:0046814
name: virion attachment, binding of host cell surface coreceptor
namespace: biological_process
def: "The process during virion attachment where a virion binds to a host cell surface receptor after an initial binding event has occurred, resulting in the fusion of the virion and host cell membranes and the initiation of viral entry." [ISBN:0879694971]
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019062 ! virion attachment to host cell surface receptor

[Term]
id: GO:0046815
name: genome retention in viral capsid
namespace: biological_process
def: "Any process by which the viral genome is retained within the capsid during genome cleavage and packaging." [PMID:9696839]
is_a: GO:0022415 ! viral reproductive process
relationship: part_of GO:0019079 ! viral genome replication

[Term]
id: GO:0046816
name: virion transport vesicle
namespace: cellular_component
def: "A vesicle used to transport the partial or complete virion between cellular compartments." [PMID:7933124]
is_a: GO:0031982 ! vesicle
is_a: GO:0043231 ! intracellular membrane-bounded organelle

[Term]
id: GO:0046817
name: chemokine receptor antagonist activity
namespace: molecular_function
def: "Interacts with chemokine receptors to reduce the action of a chemokine." [GOC:ai, ISBN:0781718325]
is_a: GO:0048019 ! receptor antagonist activity

[Term]
id: GO:0046818
name: dense nuclear body
namespace: cellular_component
def: "A location in the host cell nucleus where viral proteins colocalize late in infection prior to the onset of viral DNA synthesis. More than one site can be present simultaneously." [PMID:10233976]
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0046819
name: protein secretion by the type V secretion system
namespace: biological_process
def: "The process by which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway." [GOC:pamgo_curators]
subset: gosubset_prok
synonym: "autotransporter system" EXACT []
synonym: "protein secretion by the autotransporter system" EXACT []
synonym: "protein secretion by the type V protein secretion system" EXACT []
synonym: "type V protein secretion system" EXACT []
is_a: GO:0009306 ! protein secretion

[Term]
id: GO:0046820
name: 4-amino-4-deoxychorismate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: chorismate + glutamine = 4-amino-4-deoxychorismic acid + glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate." [GOC:krc, PMID:11495989, PMID:8346682]
comment: Note that the name 'para-aminobenzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate.
subset: gosubset_prok
synonym: "ADC synthase activity" EXACT [EC:2.6.1.85]
synonym: "aminodeoxychorismate synthase activity" RELATED []
synonym: "chorismate:L-glutamine amido-ligase activity" EXACT [EC:2.6.1.85]
synonym: "p-aminobenzoate synthetase" RELATED []
synonym: "PabB activity" RELATED [EC:2.6.1.85]
synonym: "para-aminobenzoic acid (PABA) synthase" RELATED []
synonym: "para-aminobenzoic acid synthase activity" RELATED []
xref: EC:2.6.1.85
xref: MetaCyc:PABASYN-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0046821
name: extrachromosomal DNA
namespace: cellular_component
def: "DNA structures that are not part of a chromosome." [GOC:ai]
subset: gosubset_prok
xref: Wikipedia:Extrachromosomal_DNA
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0046822
name: regulation of nucleocytoplasmic transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]
is_a: GO:0032386 ! regulation of intracellular transport
relationship: regulates GO:0006913 ! nucleocytoplasmic transport

[Term]
id: GO:0046823
name: negative regulation of nucleocytoplasmic transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus." [GOC:bf]
synonym: "down regulation of nucleocytoplasmic transport" EXACT []
synonym: "down-regulation of nucleocytoplasmic transport" EXACT []
synonym: "downregulation of nucleocytoplasmic transport" EXACT []
synonym: "inhibition of nucleocytoplasmic transport" NARROW []
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
relationship: negatively_regulates GO:0006913 ! nucleocytoplasmic transport

[Term]
id: GO:0046824
name: positive regulation of nucleocytoplasmic transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf]
synonym: "activation of nucleocytoplasmic transport" NARROW []
synonym: "stimulation of nucleocytoplasmic transport" NARROW []
synonym: "up regulation of nucleocytoplasmic transport" EXACT []
synonym: "up-regulation of nucleocytoplasmic transport" EXACT []
synonym: "upregulation of nucleocytoplasmic transport" EXACT []
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
relationship: positively_regulates GO:0006913 ! nucleocytoplasmic transport

[Term]
id: GO:0046825
name: regulation of protein export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." [GOC:bf]
synonym: "regulation of protein export from cell nucleus" EXACT []
synonym: "regulation of protein export out of nucleus" EXACT []
synonym: "regulation of protein transport from nucleus to cytoplasm" EXACT []
synonym: "regulation of protein-nucleus export" EXACT []
is_a: GO:0033157 ! regulation of intracellular protein transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
relationship: regulates GO:0006611 ! protein export from nucleus

[Term]
id: GO:0046826
name: negative regulation of protein export from nucleus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf]
synonym: "down regulation of protein export from nucleus" EXACT []
synonym: "down-regulation of protein export from nucleus" EXACT []
synonym: "downregulation of protein export from nucleus" EXACT []
synonym: "inhibition of protein export from nucleus" NARROW []
synonym: "negative regulation of protein export from cell nucleus" EXACT []
synonym: "negative regulation of protein export out of nucleus" EXACT []
synonym: "negative regulation of protein transport from nucleus to cytoplasm" EXACT []
synonym: "negative regulation of protein-nucleus export" EXACT []
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0046825 ! regulation of protein export from nucleus
is_a: GO:0051224 ! negative regulation of protein transport
relationship: negatively_regulates GO:0006611 ! protein export from nucleus

[Term]
id: GO:0046827
name: positive regulation of protein export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf]
synonym: "activation of protein export from nucleus" NARROW []
synonym: "positive regulation of protein export from cell nucleus" EXACT []
synonym: "positive regulation of protein export out of nucleus" EXACT []
synonym: "positive regulation of protein transport from nucleus to cytoplasm" EXACT []
synonym: "positive regulation of protein-nucleus export" EXACT []
synonym: "stimulation of protein export from nucleus" NARROW []
synonym: "up regulation of protein export from nucleus" EXACT []
synonym: "up-regulation of protein export from nucleus" EXACT []
synonym: "upregulation of protein export from nucleus" EXACT []
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0046825 ! regulation of protein export from nucleus
is_a: GO:0051222 ! positive regulation of protein transport
relationship: positively_regulates GO:0006611 ! protein export from nucleus

[Term]
id: GO:0046828
name: regulation of RNA import into nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus." [GOC:bf]
synonym: "regulation of RNA import into cell nucleus" EXACT []
synonym: "regulation of RNA transport from cytoplasm to nucleus" EXACT []
synonym: "regulation of RNA-nucleus import" EXACT []
is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
relationship: regulates GO:0006404 ! RNA import into nucleus

[Term]
id: GO:0046829
name: negative regulation of RNA import into nucleus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus." [GOC:bf]
synonym: "down regulation of RNA import into nucleus" EXACT []
synonym: "down-regulation of RNA import into nucleus" EXACT []
synonym: "downregulation of RNA import into nucleus" EXACT []
synonym: "inhibition of RNA import into nucleus" NARROW []
synonym: "negative regulation of RNA import into cell nucleus" EXACT []
synonym: "negative regulation of RNA transport from cytoplasm to nucleus" EXACT []
synonym: "negative regulation of RNA-nucleus import" EXACT []
is_a: GO:0032240 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0046828 ! regulation of RNA import into nucleus
relationship: negatively_regulates GO:0006404 ! RNA import into nucleus

[Term]
id: GO:0046830
name: positive regulation of RNA import into nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus." [GOC:bf]
synonym: "activation of RNA import into nucleus" NARROW []
synonym: "positive regulation of RNA import into cell nucleus" EXACT []
synonym: "positive regulation of RNA transport from cytoplasm to nucleus" EXACT []
synonym: "positive regulation of RNA-nucleus import" EXACT []
synonym: "stimulation of RNA import into nucleus" NARROW []
synonym: "up regulation of RNA import into nucleus" EXACT []
synonym: "up-regulation of RNA import into nucleus" EXACT []
synonym: "upregulation of RNA import into nucleus" EXACT []
is_a: GO:0032241 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0046828 ! regulation of RNA import into nucleus
relationship: positively_regulates GO:0006404 ! RNA import into nucleus

[Term]
id: GO:0046831
name: regulation of RNA export from nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm." [GOC:bf]
synonym: "regulation of RNA export from cell nucleus" EXACT []
synonym: "regulation of RNA export out of nucleus" EXACT []
synonym: "regulation of RNA transport from nucleus to cytoplasm" EXACT []
synonym: "regulation of RNA-nucleus export" EXACT []
is_a: GO:0032239 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
is_a: GO:0046822 ! regulation of nucleocytoplasmic transport
relationship: regulates GO:0006405 ! RNA export from nucleus

[Term]
id: GO:0046832
name: negative regulation of RNA export from nucleus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf]
synonym: "down regulation of RNA export from nucleus" EXACT []
synonym: "down-regulation of RNA export from nucleus" EXACT []
synonym: "downregulation of RNA export from nucleus" EXACT []
synonym: "inhibition of RNA export from nucleus" NARROW []
synonym: "negative regulation of RNA export from cell nucleus" EXACT []
synonym: "negative regulation of RNA export out of nucleus" EXACT []
synonym: "negative regulation of RNA transport from nucleus to cytoplasm" EXACT []
synonym: "negative regulation of RNA-nucleus export" EXACT []
is_a: GO:0032240 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport
is_a: GO:0046831 ! regulation of RNA export from nucleus
relationship: negatively_regulates GO:0006405 ! RNA export from nucleus

[Term]
id: GO:0046833
name: positive regulation of RNA export from nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf]
synonym: "activation of RNA export from nucleus" NARROW []
synonym: "positive regulation of RNA export from cell nucleus" EXACT []
synonym: "positive regulation of RNA export out of nucleus" EXACT []
synonym: "positive regulation of RNA transport from nucleus to cytoplasm" EXACT []
synonym: "positive regulation of RNA-nucleus export" EXACT []
synonym: "stimulation of RNA export from nucleus" NARROW []
synonym: "up regulation of RNA export from nucleus" EXACT []
synonym: "up-regulation of RNA export from nucleus" EXACT []
synonym: "upregulation of RNA export from nucleus" EXACT []
is_a: GO:0032241 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport
is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport
is_a: GO:0046831 ! regulation of RNA export from nucleus
relationship: positively_regulates GO:0006405 ! RNA export from nucleus

[Term]
id: GO:0046834
name: lipid phosphorylation
namespace: biological_process
def: "The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0016310 ! phosphorylation
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0046835
name: carbohydrate phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0016310 ! phosphorylation
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0046836
name: glycolipid transport
namespace: biological_process
def: "The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0006869 ! lipid transport

[Term]
id: GO:0046838
name: phosphorylated carbohydrate dephosphorylation
namespace: biological_process
def: "The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate moiety attached to it." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0016311 ! dephosphorylation
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0046839
name: phospholipid dephosphorylation
namespace: biological_process
def: "The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0016311 ! dephosphorylation
is_a: GO:0030258 ! lipid modification

[Term]
id: GO:0046841
name: trisporic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving trisporic acid, a carotenoic acid derivative used as a pheromone in some species of Zygomycota." [GOC:ai]
subset: gosubset_prok
synonym: "trisporic acid metabolism" EXACT []
is_a: GO:0019752 ! carboxylic acid metabolic process

[Term]
id: GO:0046842
name: trisporic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of trisporic acid." [GOC:ai]
subset: gosubset_prok
synonym: "trisporic acid anabolism" EXACT []
synonym: "trisporic acid biosynthesis" EXACT []
synonym: "trisporic acid formation" EXACT []
synonym: "trisporic acid synthesis" EXACT []
is_a: GO:0046841 ! trisporic acid metabolic process

[Term]
id: GO:0046843
name: dorsal appendage formation
namespace: biological_process
def: "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007306 ! eggshell chorion assembly

[Term]
id: GO:0046844
name: micropyle formation
namespace: biological_process
def: "Establishment of the micropyle, a single cone-shaped specialization of the chorion that allows sperm entry into the egg prior to fertilization." [ISBN:0879694238]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007306 ! eggshell chorion assembly

[Term]
id: GO:0046845
name: branched duct epithelial cell fate determination, open tracheal system
namespace: biological_process
def: "Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode." [GOC:mtg_sensu, PMID:10684581]
synonym: "branch cell fate determination" BROAD []
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0046847
name: filopodium assembly
namespace: biological_process
def: "The assembly of a filopodium, a very long microspike extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or by the growth cone of a developing nerve cell axon." [GOC:dph, GOC:mah, GOC:tb]
synonym: "filopodia biosynthesis" RELATED []
synonym: "filopodia formation" RELATED []
synonym: "filopodium formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0030035 ! microspike assembly

[Term]
id: GO:0046848
name: hydroxyapatite binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentine." [http://cancerweb.ncl.ac.uk/]
synonym: "hydroxylapatite binding" EXACT [GOC:vk]
is_a: GO:0005488 ! binding

[Term]
id: GO:0046849
name: bone remodeling
namespace: biological_process
def: "The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis." [http://cancerweb.ncl.ac.uk/]
synonym: "bone remodelling" EXACT []
xref: Wikipedia:Bone_remodeling
is_a: GO:0048771 ! tissue remodeling

[Term]
id: GO:0046850
name: regulation of bone remodeling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity." [GOC:ai]
is_a: GO:0034103 ! regulation of tissue remodeling
relationship: regulates GO:0046849 ! bone remodeling

[Term]
id: GO:0046851
name: negative regulation of bone remodeling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone remodeling." [GOC:ai]
synonym: "down regulation of bone remodeling" EXACT []
synonym: "down-regulation of bone remodeling" EXACT []
synonym: "downregulation of bone remodeling" EXACT []
synonym: "inhibition of bone remodeling" NARROW []
is_a: GO:0034104 ! negative regulation of tissue remodeling
is_a: GO:0046850 ! regulation of bone remodeling
relationship: negatively_regulates GO:0046849 ! bone remodeling

[Term]
id: GO:0046852
name: positive regulation of bone remodeling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bone remodeling." [GOC:ai]
synonym: "activation of bone remodeling" NARROW []
synonym: "stimulation of bone remodeling" NARROW []
synonym: "up regulation of bone remodeling" EXACT []
synonym: "up-regulation of bone remodeling" EXACT []
synonym: "upregulation of bone remodeling" EXACT []
is_a: GO:0034105 ! positive regulation of tissue remodeling
is_a: GO:0046850 ! regulation of bone remodeling
relationship: positively_regulates GO:0046849 ! bone remodeling

[Term]
id: GO:0046853
name: inositol and derivative phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group into inositol or an inositol derivative. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms." [ChEBI:24848, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "myo-inositol and derivative phosphorylation" NARROW []
is_a: GO:0006020 ! inositol metabolic process
is_a: GO:0046835 ! carbohydrate phosphorylation

[Term]
id: GO:0046854
name: phosphoinositide phosphorylation
namespace: biological_process
alt_id: GO:0046837
def: "The process of introducing one or more phosphate groups into a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphatidylinositol phosphate biosynthetic process" NARROW []
synonym: "phosphatidylinositol phosphate phosphorylation" NARROW []
synonym: "phosphatidylinositol phosphorylation" NARROW []
synonym: "PIP biosynthesis" NARROW []
synonym: "PtdInsP biosynthesis" NARROW []
xref: Reactome:110453 "Phosphorylation of PIP2 to PIP3 by Dp110"
is_a: GO:0030384 ! phosphoinositide metabolic process
is_a: GO:0046834 ! lipid phosphorylation

[Term]
id: GO:0046855
name: inositol phosphate dephosphorylation
namespace: biological_process
def: "The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "myo-inositol phosphate dephosphorylation" NARROW []
is_a: GO:0006020 ! inositol metabolic process
is_a: GO:0046838 ! phosphorylated carbohydrate dephosphorylation

[Term]
id: GO:0046856
name: phosphoinositide dephosphorylation
namespace: biological_process
alt_id: GO:0046840
def: "The process of removing one or more phosphate groups from a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phosphatidylinositol dephosphorylation" NARROW []
synonym: "phosphatidylinositol phosphate catabolic process" NARROW []
synonym: "phosphatidylinositol phosphate dephosphorylation" NARROW []
synonym: "PIP catabolism" NARROW []
synonym: "PtdInsP catabolism" NARROW []
synonym: "PtdInsP dephosphorylation" NARROW []
xref: Reactome:110459 "PIP3 dephosphorylated to PIP2 by DPTEN"
is_a: GO:0030384 ! phosphoinositide metabolic process
is_a: GO:0046839 ! phospholipid dephosphorylation

[Term]
id: GO:0046857
name: oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]
subset: gosubset_prok
xref: EC:1.7.1
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0046858
name: chlorosome
namespace: cellular_component
def: "A large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:14729689, PMID:15298919]
subset: gosubset_prok
xref: Wikipedia:Chlorosome
is_a: GO:0043232 ! intracellular non-membrane-bounded organelle

[Term]
id: GO:0046859
name: hydrogenosomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a hydrogenosome." [GOC:ai]
synonym: "hydrogenosome membrane" EXACT []
is_a: GO:0031090 ! organelle membrane
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0042566 ! hydrogenosome

[Term]
id: GO:0046860
name: glycosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a glycosome." [GOC:ai]
is_a: GO:0005778 ! peroxisomal membrane
relationship: part_of GO:0020015 ! glycosome

[Term]
id: GO:0046861
name: glyoxysomal membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a glyoxysome." [GOC:ai]
synonym: "glyoxysome membrane" EXACT []
is_a: GO:0005778 ! peroxisomal membrane

[Term]
id: GO:0046862
name: chromoplast membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround a chromoplast and form the chromoplast envelope." [GOC:ai, GOC:mah]
is_a: GO:0042170 ! plastid membrane
relationship: part_of GO:0031898 ! chromoplast envelope

[Term]
id: GO:0046863
name: ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity
namespace: molecular_function
def: "Increases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate." [PMID:10430961, PMID:10965036, PMID:2404515]
comment: See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'.
synonym: "ribulose-1,5-bisphosphate carboxylase/oxygenase activase activity" EXACT [GOC:dph, GOC:tb]
synonym: "rubisco activase activity" EXACT []
synonym: "rubisco activator" EXACT []
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0046864
name: isoprenoid transport
namespace: biological_process
def: "The directed movement of isoprenoids into, out of, within or between cells by means of some external agent such as a transporter or pore. Isoprenoids comprise a group of compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:ai]
subset: goslim_pir
is_a: GO:0006869 ! lipid transport

[Term]
id: GO:0046865
name: terpenoid transport
namespace: biological_process
def: "The directed movement of terpenoids into, out of, within or between cells by means of some external agent such as a transporter or pore. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups." [GOC:ai]
is_a: GO:0046864 ! isoprenoid transport

[Term]
id: GO:0046866
name: tetraterpenoid transport
namespace: biological_process
def: "The directed movement of tetraterpenoids into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetraterpenoids are terpenoids with eight isoprene units." [GOC:ai]
is_a: GO:0046865 ! terpenoid transport

[Term]
id: GO:0046867
name: carotenoid transport
namespace: biological_process
def: "The directed movement of carotenoids into, out of, within or between cells by means of some external agent such as a transporter or pore. Carotenoids are tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:ai]
is_a: GO:0046866 ! tetraterpenoid transport

[Term]
id: GO:0046868
name: mesosome
namespace: cellular_component
def: "An intracellular, often complex, membranous structure, sometimes with additional membranous lamellae inside, found in bacteria. They are associated with synthesis of DNA and secretion of proteins." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363]
subset: gosubset_prok
xref: Wikipedia:Mesosome
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0046869
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide
namespace: biological_process
def: "The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide." [RESID:AA0331]
subset: gosubset_prok
synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato diiron disulphide" EXACT []
xref: RESID:AA0331
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0046870
name: cadmium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with cadmium (Cd) ions." [GOC:ai]
subset: gosubset_prok
synonym: "cadmium binding" EXACT []
synonym: "copper/cadmium binding" BROAD []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0046871
name: N-acetylgalactosamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine." [ChEBI:28800, GOC:ai, http://cancerweb.ncl.ac.uk/]
synonym: "N-acetylgalactosamine lectin" RELATED []
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0046872
name: metal ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any metal ion." [GOC:ai]
subset: gosubset_prok
synonym: "heavy metal binding" NARROW []
synonym: "metal binding" EXACT []
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0046873
name: metal ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of metal ions from one side of a membrane to the other." [GOC:ai]
subset: gosubset_prok
synonym: "heavy metal ion porter activity" NARROW []
synonym: "heavy metal ion transporter activity" NARROW []
synonym: "heavy metal ion:hydrogen symporter activity" NARROW []
synonym: "heavy metal-exporting ATPase activity" NARROW []
synonym: "high affinity metal ion uptake transporter activity" NARROW []
synonym: "low affinity metal ion uptake transporter activity" NARROW []
is_a: GO:0008324 ! cation transmembrane transporter activity

[Term]
id: GO:0046874
name: quinolinate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai]
subset: gosubset_prok
synonym: "quinolinate metabolism" EXACT []
is_a: GO:0043648 ! dicarboxylic acid metabolic process

[Term]
id: GO:0046875
name: ephrin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an ephrin receptor." [GOC:ai]
synonym: "Eph receptor binding" EXACT []
synonym: "ephrin" NARROW []
synonym: "GPI-linked ephrin" NARROW []
synonym: "transmembrane ephrin" NARROW []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0046876
name: 3,4-didehydroretinal binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "blue-sensitive opsin" NARROW []
synonym: "green-sensitive opsin" NARROW []
synonym: "long-wave-sensitive opsin" NARROW []
synonym: "opsin" NARROW []
synonym: "red-sensitive opsin" NARROW []
synonym: "short-wave-sensitive opsin" NARROW []
synonym: "UV-sensitive opsin" NARROW []
synonym: "violet-sensitive opsin" NARROW []
is_a: GO:0005501 ! retinoid binding

[Term]
id: GO:0046877
name: regulation of saliva secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or group of cells." [GOC:ai]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051046 ! regulation of secretion
relationship: regulates GO:0046541 ! saliva secretion

[Term]
id: GO:0046878
name: positive regulation of saliva secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of saliva." [GOC:ai]
synonym: "activation of saliva secretion" NARROW []
synonym: "stimulation of saliva secretion" NARROW []
synonym: "up regulation of saliva secretion" EXACT []
synonym: "up-regulation of saliva secretion" EXACT []
synonym: "upregulation of saliva secretion" EXACT []
is_a: GO:0046877 ! regulation of saliva secretion
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0060456 ! positive regulation of digestive system process
relationship: positively_regulates GO:0046541 ! saliva secretion

[Term]
id: GO:0046879
name: hormone secretion
namespace: biological_process
def: "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0003001 ! generation of a signal involved in cell-cell signaling
is_a: GO:0009914 ! hormone transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0046880
name: regulation of follicle-stimulating hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai]
is_a: GO:0032276 ! regulation of gonadotropin secretion
relationship: regulates GO:0046884 ! follicle-stimulating hormone secretion

[Term]
id: GO:0046881
name: positive regulation of follicle-stimulating hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai]
synonym: "activation of follicle-stimulating hormone secretion" NARROW []
synonym: "stimulation of follicle-stimulating hormone secretion" NARROW []
synonym: "up regulation of follicle-stimulating hormone secretion" EXACT []
synonym: "up-regulation of follicle-stimulating hormone secretion" EXACT []
synonym: "upregulation of follicle-stimulating hormone secretion" EXACT []
is_a: GO:0032278 ! positive regulation of gonadotropin secretion
is_a: GO:0046880 ! regulation of follicle-stimulating hormone secretion
relationship: positively_regulates GO:0046884 ! follicle-stimulating hormone secretion

[Term]
id: GO:0046882
name: negative regulation of follicle-stimulating hormone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai]
synonym: "down regulation of follicle-stimulating hormone secretion" EXACT []
synonym: "down-regulation of follicle-stimulating hormone secretion" EXACT []
synonym: "downregulation of follicle-stimulating hormone secretion" EXACT []
synonym: "inhibition of follicle-stimulating hormone secretion" NARROW []
is_a: GO:0032277 ! negative regulation of gonadotropin secretion
is_a: GO:0046880 ! regulation of follicle-stimulating hormone secretion
relationship: negatively_regulates GO:0046884 ! follicle-stimulating hormone secretion

[Term]
id: GO:0046883
name: regulation of hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells." [GOC:ai]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0046879 ! hormone secretion

[Term]
id: GO:0046884
name: follicle-stimulating hormone secretion
namespace: biological_process
def: "The regulated release of follicle-stimulating hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "follitropin secretion" EXACT []
synonym: "FSH secretion" EXACT []
is_a: GO:0032274 ! gonadotropin secretion

[Term]
id: GO:0046885
name: regulation of hormone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai]
synonym: "regulation of hormone anabolism" EXACT []
synonym: "regulation of hormone biosynthesis" EXACT []
synonym: "regulation of hormone formation" EXACT []
synonym: "regulation of hormone synthesis" EXACT []
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0032350 ! regulation of hormone metabolic process
relationship: regulates GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0046886
name: positive regulation of hormone biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai]
synonym: "activation of hormone biosynthetic process" NARROW []
synonym: "positive regulation of hormone anabolism" EXACT []
synonym: "positive regulation of hormone biosynthesis" EXACT []
synonym: "positive regulation of hormone formation" EXACT []
synonym: "positive regulation of hormone synthesis" EXACT []
synonym: "stimulation of hormone biosynthetic process" NARROW []
synonym: "up regulation of hormone biosynthetic process" EXACT []
synonym: "up-regulation of hormone biosynthetic process" EXACT []
synonym: "upregulation of hormone biosynthetic process" EXACT []
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0046885 ! regulation of hormone biosynthetic process
relationship: positively_regulates GO:0042446 ! hormone biosynthetic process

[Term]
id: GO:0046887
name: positive regulation of hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells." [GOC:ai]
synonym: "activation of hormone secretion" NARROW []
synonym: "stimulation of hormone secretion" NARROW []
synonym: "up regulation of hormone secretion" EXACT []
synonym: "up-regulation of hormone secretion" EXACT []
synonym: "upregulation of hormone secretion" EXACT []
is_a: GO:0046883 ! regulation of hormone secretion
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051047 ! positive regulation of secretion
relationship: positively_regulates GO:0046879 ! hormone secretion

[Term]
id: GO:0046888
name: negative regulation of hormone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells." [GOC:ai]
synonym: "down regulation of hormone secretion" EXACT []
synonym: "down-regulation of hormone secretion" EXACT []
synonym: "downregulation of hormone secretion" EXACT []
synonym: "inhibition of hormone secretion" NARROW []
is_a: GO:0046883 ! regulation of hormone secretion
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051048 ! negative regulation of secretion
relationship: negatively_regulates GO:0046879 ! hormone secretion

[Term]
id: GO:0046889
name: positive regulation of lipid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
subset: gosubset_prok
synonym: "activation of lipid biosynthetic process" NARROW []
synonym: "positive regulation of lipid anabolism" EXACT []
synonym: "positive regulation of lipid biosynthesis" EXACT []
synonym: "positive regulation of lipid formation" EXACT []
synonym: "positive regulation of lipid synthesis" EXACT []
synonym: "positive regulation of lipogenesis" EXACT [GOC:sl]
synonym: "stimulation of lipid biosynthetic process" NARROW []
synonym: "up regulation of lipid biosynthetic process" EXACT []
synonym: "up-regulation of lipid biosynthetic process" EXACT []
synonym: "upregulation of lipid biosynthetic process" EXACT []
is_a: GO:0009891 ! positive regulation of biosynthetic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: positively_regulates GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0046890
name: regulation of lipid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of lipid anabolism" EXACT []
synonym: "regulation of lipid biosynthesis" EXACT []
synonym: "regulation of lipid formation" EXACT []
synonym: "regulation of lipid synthesis" EXACT []
synonym: "regulation of lipogenesis" EXACT [GOC:sl]
is_a: GO:0009889 ! regulation of biosynthetic process
is_a: GO:0019216 ! regulation of lipid metabolic process
relationship: regulates GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0046891
name: peptidyl-cysteine S-carbamoylation
namespace: biological_process
def: "The carbamoylation of peptidyl-cysteine to form peptidyl-S-carbamoyl-L-cysteine." [RESID:AA0332]
subset: gosubset_prok
xref: RESID:AA0332
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0046892
name: peptidyl-S-carbamoyl-L-cysteine dehydration
namespace: biological_process
def: "The dehydration of peptidyl-S-carbamoyl-L-cysteine to form peptidyl-S-cyano-L-cysteine." [PMID:12586941, RESID:AA0333]
subset: gosubset_prok
synonym: "formation of peptidyl-S-cyanocysteine" EXACT []
synonym: "formation of peptidyl-serine thiocyanate ester" EXACT []
xref: RESID:AA0333
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018249 ! protein amino acid dehydration

[Term]
id: GO:0046893
name: iron incorporation into hydrogenase diiron subcluster via L-cysteine ligation
namespace: biological_process
def: "The incorporation of iron into an L-cysteinyl diiron subcluster, found in Fe-hydrogenase." [RESID:AA0334]
subset: gosubset_prok
xref: RESID:AA0334
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0046894
name: enzyme active site formation via S-amidino-L-cysteine
namespace: biological_process
def: "The transient amidinylation of peptidyl-cysteine to form peptidyl-S-amidino-L-cysteine." [RESID:AA0335]
subset: gosubset_prok
xref: RESID:AA0335
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018307 ! enzyme active site formation

[Term]
id: GO:0046895
name: N-terminal peptidyl-isoleucine methylation
namespace: biological_process
def: "The methylation of the N-terminal isoleucine of proteins to form the derivative N-methyl-L-isoleucine." [RESID:AA0336]
subset: gosubset_prok
xref: RESID:AA0336
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018203 ! peptidyl-isoleucine modification

[Term]
id: GO:0046896
name: N-terminal peptidyl-leucine methylation
namespace: biological_process
def: "The methylation of the N-terminal leucine of proteins to form the derivative N-methyl-L-leucine." [RESID:AA0337]
subset: gosubset_prok
xref: RESID:AA0337
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018204 ! peptidyl-leucine modification

[Term]
id: GO:0046897
name: N-terminal peptidyl-tyrosine methylation
namespace: biological_process
def: "The methylation of the N-terminal tyrosine of proteins to form the derivative N-methyl-L-tyrosine." [RESID:AA0338]
subset: gosubset_prok
xref: RESID:AA0338
is_a: GO:0006480 ! N-terminal protein amino acid methylation
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0046898
name: response to cycloheximide
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes." [ChEBI:27641, GOC:ef, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "response to actidione" EXACT []
is_a: GO:0014071 ! response to cycloalkane

[Term]
id: GO:0046899
name: nucleoside triphosphate adenylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP." [EC:2.7.4.10]
synonym: "GTP:AMP phosphotransferase" NARROW []
synonym: "guanosine triphosphate-adenylate kinase" NARROW []
synonym: "isozyme 3 of adenylate kinase activity" EXACT [EC:2.7.4.10]
synonym: "nucleoside triphosphate-adenosine monophosphate transphosphorylase activity" EXACT []
synonym: "nucleoside-triphosphate-adenylate kinase activity" EXACT []
synonym: "nucleoside-triphosphate:AMP phosphotransferase activity" EXACT [EC:2.7.4.10]
xref: EC:2.7.4.10
xref: MetaCyc:2.7.4.10-RXN
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity

[Term]
id: GO:0046900
name: tetrahydrofolylpolyglutamate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai]
subset: gosubset_prok
synonym: "tetrahydrofolyl-[Glu](n) metabolic process" EXACT []
synonym: "tetrahydrofolyl-[Glu](n) metabolism" EXACT []
synonym: "tetrahydrofolylpolyglutamate metabolism" EXACT []
is_a: GO:0006575 ! cellular amino acid derivative metabolic process
is_a: GO:0006760 ! folic acid and derivative metabolic process
is_a: GO:0042558 ! pteridine and derivative metabolic process

[Term]
id: GO:0046901
name: tetrahydrofolylpolyglutamate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai]
subset: gosubset_prok
synonym: "tetrahydrofolyl-[Glu](n) biosynthesis" EXACT []
synonym: "tetrahydrofolyl-[Glu](n) biosynthetic process" EXACT []
synonym: "tetrahydrofolylpolyglutamate anabolism" EXACT []
synonym: "tetrahydrofolylpolyglutamate biosynthesis" EXACT []
synonym: "tetrahydrofolylpolyglutamate formation" EXACT []
synonym: "tetrahydrofolylpolyglutamate synthesis" EXACT []
is_a: GO:0009396 ! folic acid and derivative biosynthetic process
is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process
is_a: GO:0042559 ! pteridine and derivative biosynthetic process
is_a: GO:0046900 ! tetrahydrofolylpolyglutamate metabolic process

[Term]
id: GO:0046902
name: regulation of mitochondrial membrane permeability
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf]
synonym: "regulation of transport across mitochondrial membrane" EXACT []
is_a: GO:0007006 ! mitochondrial membrane organization
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0006839 ! mitochondrial transport

[Term]
id: GO:0046903
name: secretion
namespace: biological_process
def: "The controlled release of a substance by a cell, a group of cells, or a tissue." [GOC:ai]
subset: goslim_goa
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0006810 ! transport

[Term]
id: GO:0046904
name: calcium oxalate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0046905
name: phytoene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: prephytoene pyrophosphate = phytoene + pyrophosphate." [GOC:ai, PMID:12641468]
comment: Note that this should not be confused with 'geranylgeranyl-diphosphate geranylgeranyltransferase activity ; GO:0016767', EC:2.5.1.32. This activity is the second part of the formation of phytoene from geranylgeranyl-diphosphate, the first stage of which is catalyzed by EC:2.5.1.32.
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0046906
name: tetrapyrrole binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
synonym: "porphyrin binding" NARROW []
is_a: GO:0005488 ! binding

[Term]
id: GO:0046907
name: intracellular transport
namespace: biological_process
def: "The directed movement of substances within a cell." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006810 ! transport
is_a: GO:0051649 ! establishment of localization in cell

[Term]
id: GO:0046908
name: negative regulation of crystal formation
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of the spontaneous (nonenzymatic) formation of crystals in a solution, for example, calcium oxalate crystals in urine." [GOC:ai]
comment: This term was made obsolete because a more appropriate term was created.
synonym: "negative regulation of mineralization" RELATED []
is_obsolete: true
replaced_by: GO:0050801

[Term]
id: GO:0046909
name: intermembrane transport
namespace: biological_process
def: "The directed movement of substances between the intracellular membranes of a cell, for example, the transfer of glycolipids from the endoplasmic reticulum to other cellular membrane structures in which they reside." [GOC:ai, PMID:10671554]
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0046910
name: pectinesterase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of any pectinesterase enzyme." [GOC:ai, PMID:10880981]
comment: See also the molecular function term 'pectinesterase activity ; GO:0030599'.
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0046911
name: metal chelating activity
namespace: molecular_function
def: "The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363]
subset: gosubset_prok
synonym: "heavy metal chelation" NARROW []
synonym: "metal chelation" EXACT []
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0046912
name: transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
namespace: molecular_function
def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl]
subset: gosubset_prok
xref: EC:2.3.3
is_a: GO:0016746 ! transferase activity, transferring acyl groups

[Term]
id: GO:0046914
name: transition metal ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0046872 ! metal ion binding

[Term]
id: GO:0046915
name: transition metal ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0046873 ! metal ion transmembrane transporter activity

[Term]
id: GO:0046916
name: cellular transition metal ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of transition metal ions at the level of a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0006875 ! cellular metal ion homeostasis
is_a: GO:0055076 ! transition metal ion homeostasis

[Term]
id: GO:0046917
name: triphosphoribosyl-dephospho-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine." [EC:2.7.8.25]
subset: gosubset_prok
synonym: "2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase activity" EXACT [EC:2.7.8.25]
synonym: "ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase activity" EXACT [EC:2.7.8.25]
synonym: "ATP:dephospho-CoA 5-triphosphoribosyl transferase activity" EXACT []
synonym: "CitG activity" RELATED [EC:2.7.8.25]
xref: EC:2.7.8.25
xref: MetaCyc:2.7.8.25-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0046918
name: N-terminal peptidyl-glycine N-palmitoylation
namespace: biological_process
def: "The palmitoylation of the N-terminal glycine of proteins to form the derivative N-palmitoyl-glycine." [RESID:AA0339]
subset: gosubset_prok
xref: RESID:AA0339
is_a: GO:0006500 ! N-terminal protein palmitoylation

[Term]
id: GO:0046919
name: pyruvyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another." [GOC:ai]
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0046920
name: alpha(1,3)-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,3)-linkage." [GOC:ai]
xref: EC:2.4.1.-
is_a: GO:0008417 ! fucosyltransferase activity

[Term]
id: GO:0046921
name: alpha(1,6)-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,6)-linkage." [GOC:ai]
xref: EC:2.4.1.-
is_a: GO:0008417 ! fucosyltransferase activity

[Term]
id: GO:0046922
name: peptide-O-fucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221]
synonym: "GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.221]
synonym: "GDP-fucose protein O-fucosyltransferase activity" EXACT [EC:2.4.1.221]
synonym: "GDP-fucose:polypeptide fucosyltransferase activity" EXACT [EC:2.4.1.221]
synonym: "GDP-L-fucose:polypeptide fucosyltransferase activity" EXACT [EC:2.4.1.221]
xref: EC:2.4.1.221
xref: MetaCyc:2.4.1.221-RXN
is_a: GO:0008417 ! fucosyltransferase activity

[Term]
id: GO:0046923
name: ER retention sequence binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER." [GOC:ai]
synonym: "endoplasmic reticulum retention sequence binding" EXACT []
is_a: GO:0005048 ! signal sequence binding

[Term]
id: GO:0046924
name: peptide cross-linking via 2-(S-L-cysteinyl)-L-phenylalanine
namespace: biological_process
def: "The posttranslational cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-L-phenylalanine." [PMID:12696888, RESID:AA0340]
subset: gosubset_prok
xref: RESID:AA0340
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018207 ! peptidyl-phenylalanine modification

[Term]
id: GO:0046925
name: peptide cross-linking via 2-(S-L-cysteinyl)-D-phenylalanine
namespace: biological_process
def: "The posttranslational cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine." [PMID:12696888, RESID:AA0341]
subset: gosubset_prok
xref: RESID:AA0341
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018207 ! peptidyl-phenylalanine modification

[Term]
id: GO:0046926
name: peptide cross-linking via 2-(S-L-cysteinyl)-D-allo-threonine
namespace: biological_process
def: "The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine." [PMID:12696888, RESID:AA0342]
subset: gosubset_prok
xref: RESID:AA0342
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0046927
name: peptidyl-threonine racemization
namespace: biological_process
def: "The racemization of peptidyl-L-threo-threonine at the alpha-carbon to form D-allo-threonine. This is coupled with the formation of the cross-link 2-(S-L-cysteinyl)-D-allo-threonine." [PMID:12696888]
subset: gosubset_prok
is_a: GO:0018085 ! peptidyl-L-amino acid racemization
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0046928
name: regulation of neurotransmitter secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell or group of cells." [GOC:ai]
is_a: GO:0050804 ! regulation of synaptic transmission
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051588 ! regulation of neurotransmitter transport
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0046929
name: negative regulation of neurotransmitter secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:ai]
synonym: "conotoxin activity" NARROW []
synonym: "down regulation of neurotransmitter secretion" EXACT []
synonym: "down-regulation of neurotransmitter secretion" EXACT []
synonym: "downregulation of neurotransmitter secretion" EXACT []
synonym: "inhibition of neurotransmitter secretion" NARROW []
is_a: GO:0046928 ! regulation of neurotransmitter secretion
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051589 ! negative regulation of neurotransmitter transport
relationship: negatively_regulates GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0046930
name: pore complex
namespace: cellular_component
def: "Any small opening in a membrane that allows the passage of gases and/or liquids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "channel-forming toxin activity" RELATED []
synonym: "pore" EXACT []
synonym: "pore-forming toxin activity" RELATED []
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0016021 ! integral to membrane

[Term]
id: GO:0046931
name: pore complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases." [GOC:jl, GOC:mah]
comment: See also the cellular component term 'pore complex ; GO:0046930'.
subset: gosubset_prok
synonym: "channel-forming toxin activity" RELATED []
synonym: "pore biosynthesis" EXACT []
synonym: "pore complex biogenesis" RELATED [GOC:mah]
synonym: "pore formation" EXACT []
synonym: "pore-forming toxin activity" RELATED []
is_a: GO:0009987 ! cellular process
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0046932
name: sodium-transporting ATP synthase activity, rotational mechanism
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) = ATP + H2O + Na+(in), by a rotational mechanism." [EC:3.6.3.15, TC:3.A.2.1.2]
synonym: "sodium-translocating F-type ATPase activity" EXACT []
synonym: "sodium-transporting two-sector ATPase activity" EXACT []
xref: MetaCyc:3.6.3.15-RXN
is_a: GO:0015081 ! sodium ion transmembrane transporter activity

[Term]
id: GO:0046933
name: hydrogen ion transporting ATP synthase activity, rotational mechanism
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1]
subset: gosubset_prok
synonym: "H+-transporting ATP synthase activity" EXACT [EC:3.6.3.14]
synonym: "hydrogen ion translocating F-type ATPase activity" EXACT []
synonym: "hydrogen ion transporting two-sector ATPase activity" EXACT []
xref: MetaCyc:ATPSYN-RXN
xref: Reactome:78757 "hydrogen ion transporting ATP synthase activity, rotational mechanism"
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity

[Term]
id: GO:0046934
name: phosphatidylinositol-4,5-bisphosphate 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate." [EC:2.7.1.153]
synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.153]
synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW []
synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW []
synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW []
synonym: "type I phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.153]
xref: EC:2.7.1.153
xref: MetaCyc:2.7.1.153-RXN
xref: Reactome:78763 "phosphatidylinositol-4,5-bisphosphate 3-kinase activity"
is_a: GO:0035004 ! phosphoinositide 3-kinase activity

[Term]
id: GO:0046935
name: 1-phosphatidylinositol-3-kinase regulator activity
namespace: molecular_function
def: "Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity." [GOC:ai]
comment: See also the molecular function term '1-phosphatidylinositol-3-kinase activity ; GO:0016303'.
synonym: "phosphatidylinositol 3-kinase regulator activity" EXACT []
synonym: "phosphatidylinositol 3-kinase, class I, regulator activity" NARROW []
is_a: GO:0035014 ! phosphoinositide 3-kinase regulator activity

[Term]
id: GO:0046936
name: deoxyadenosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxyadenosine + H2O = deoxyinosine + NH3." [EC:3.5.4.4, GOC:ai]
synonym: "deoxyadenosine deaminase reaction" EXACT []
xref: MetaCyc:ADDALT-RXN
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0046937
name: phytochelatin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phytochelatin metabolism" EXACT []
is_a: GO:0006518 ! peptide metabolic process
is_a: GO:0019748 ! secondary metabolic process

[Term]
id: GO:0046938
name: phytochelatin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "phytochelatin anabolism" EXACT []
synonym: "phytochelatin biosynthesis" EXACT []
synonym: "phytochelatin formation" EXACT []
synonym: "phytochelatin synthesis" EXACT []
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:0046937 ! phytochelatin metabolic process

[Term]
id: GO:0046939
name: nucleotide phosphorylation
namespace: biological_process
def: "The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai]
subset: gosubset_prok
is_a: GO:0009117 ! nucleotide metabolic process
is_a: GO:0016310 ! phosphorylation

[Term]
id: GO:0046940
name: nucleoside monophosphate phosphorylation
namespace: biological_process
def: "The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside." [GOC:ai]
subset: gosubset_prok
is_a: GO:0009123 ! nucleoside monophosphate metabolic process
is_a: GO:0046939 ! nucleotide phosphorylation

[Term]
id: GO:0046941
name: azetidine-2-carboxylic acid acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid." [PMID:12761200]
xref: EC:2.3.1.-
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0046942
name: carboxylic acid transport
namespace: biological_process
def: "The directed movement of carboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015849 ! organic acid transport

[Term]
id: GO:0046943
name: carboxylic acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of carboxylic acids from one side of the membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai]
subset: gosubset_prok
xref: Reactome:78420 "carboxylic acid transmembrane transporter activity"
is_a: GO:0005342 ! organic acid transmembrane transporter activity

[Term]
id: GO:0046944
name: protein amino acid carbamoylation
namespace: biological_process
def: "The addition of a carbamoyl group to a protein amino acid. A carbamoyl group is the acyl group -CO-NH2." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0046945
name: N-terminal peptidyl-alanine N-carbamoylation
namespace: biological_process
def: "The carbamylation of the N-terminal alanine of proteins to form the derivative N-carbamoyl-L-alanine." [RESID:AA0343]
subset: gosubset_prok
synonym: "N-terminal peptidyl-alanine N-carbamylation" RELATED []
xref: RESID:AA0343
is_a: GO:0018194 ! peptidyl-alanine modification
is_a: GO:0046944 ! protein amino acid carbamoylation
is_a: GO:0050990 ! N-terminal protein amino acid carbamoylation

[Term]
id: GO:0046946
name: hydroxylysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. Hydroxylysine is found in collagen and commonly has galactose and then glucose added sequentially by glycosyltransferases." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "hydroxylysine metabolism" EXACT []
is_a: GO:0009066 ! aspartate family amino acid metabolic process

[Term]
id: GO:0046947
name: hydroxylysine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "hydroxylysine anabolism" EXACT []
synonym: "hydroxylysine biosynthesis" EXACT []
synonym: "hydroxylysine formation" EXACT []
synonym: "hydroxylysine synthesis" EXACT []
is_a: GO:0009067 ! aspartate family amino acid biosynthetic process
is_a: GO:0046946 ! hydroxylysine metabolic process

[Term]
id: GO:0046948
name: hydroxylysine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "hydroxylysine breakdown" EXACT []
synonym: "hydroxylysine catabolism" EXACT []
synonym: "hydroxylysine degradation" EXACT []
is_a: GO:0009068 ! aspartate family amino acid catabolic process
is_a: GO:0046946 ! hydroxylysine metabolic process

[Term]
id: GO:0046949
name: fatty-acyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "fatty-acyl-CoA anabolism" EXACT []
synonym: "fatty-acyl-CoA biosynthesis" EXACT []
synonym: "fatty-acyl-CoA formation" EXACT []
synonym: "fatty-acyl-CoA synthesis" EXACT []
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0071616 ! acyl-CoA biosynthetic process

[Term]
id: GO:0046950
name: cellular ketone body metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
synonym: "ketone body metabolism" EXACT []
xref: Reactome:448513 "Ketone body metabolism"
xref: Reactome:469643 "Ketone body metabolism"
xref: Reactome:487355 "Ketone body metabolism"
xref: Reactome:507306 "Ketone body metabolism"
xref: Reactome:517320 "Ketone body metabolism"
xref: Reactome:526203 "Ketone body metabolism"
xref: Reactome:531089 "Ketone body metabolism"
xref: Reactome:536462 "Ketone body metabolism"
xref: Reactome:542166 "Ketone body metabolism"
xref: Reactome:547524 "Ketone body metabolism"
xref: Reactome:552117 "Ketone body metabolism"
xref: Reactome:557709 "Ketone body metabolism"
xref: Reactome:568324 "Ketone body metabolism"
xref: Reactome:581526 "Ketone body metabolism"
xref: Reactome:592413 "Ketone body metabolism"
xref: Reactome:595296 "Ketone body metabolism"
xref: Reactome:597271 "Ketone body metabolism"
xref: Reactome:598125 "Ketone body metabolism"
xref: Reactome:599612 "Ketone body metabolism"
xref: Reactome:602416 "Ketone body metabolism"
xref: Reactome:74182 "Ketone body metabolism"
is_a: GO:0044237 ! cellular metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0046951
name: ketone body biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ketone body anabolism" EXACT []
synonym: "ketone body biosynthesis" EXACT []
synonym: "ketone body formation" EXACT []
synonym: "ketone body synthesis" EXACT []
xref: Reactome:448512 "Synthesis of Ketone Bodies"
xref: Reactome:469642 "Synthesis of Ketone Bodies"
xref: Reactome:487354 "Synthesis of Ketone Bodies"
xref: Reactome:507305 "Synthesis of Ketone Bodies"
xref: Reactome:517319 "Synthesis of Ketone Bodies"
xref: Reactome:526202 "Synthesis of Ketone Bodies"
xref: Reactome:531088 "Synthesis of Ketone Bodies"
xref: Reactome:536461 "Synthesis of Ketone Bodies"
xref: Reactome:542165 "Synthesis of Ketone Bodies"
xref: Reactome:547523 "Synthesis of Ketone Bodies"
xref: Reactome:552116 "Synthesis of Ketone Bodies"
xref: Reactome:557708 "Synthesis of Ketone Bodies"
xref: Reactome:568323 "Synthesis of Ketone Bodies"
xref: Reactome:581525 "Synthesis of Ketone Bodies"
xref: Reactome:592412 "Synthesis of Ketone Bodies"
xref: Reactome:595295 "Synthesis of Ketone Bodies"
xref: Reactome:597270 "Synthesis of Ketone Bodies"
xref: Reactome:598124 "Synthesis of Ketone Bodies"
xref: Reactome:599611 "Synthesis of Ketone Bodies"
xref: Reactome:602415 "Synthesis of Ketone Bodies"
xref: Reactome:77111 "Synthesis of Ketone Bodies"
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0044283 ! small molecule biosynthetic process
is_a: GO:0046950 ! cellular ketone body metabolic process

[Term]
id: GO:0046952
name: ketone body catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "ketone body breakdown" EXACT []
synonym: "ketone body catabolism" EXACT []
synonym: "ketone body degradation" EXACT []
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0044282 ! small molecule catabolic process
is_a: GO:0046950 ! cellular ketone body metabolic process

[Term]
id: GO:0046956
name: positive phototaxis
namespace: biological_process
alt_id: GO:0046954
def: "The directed movement of a cell or organism towards a source of light." [GOC:ai]
synonym: "positive phototactic behavior" EXACT []
synonym: "positive phototactic behaviour" EXACT []
synonym: "positive taxis in response to light" EXACT []
is_a: GO:0042331 ! phototaxis
is_a: GO:0052128 ! positive energy taxis

[Term]
id: GO:0046957
name: negative phototaxis
namespace: biological_process
alt_id: GO:0046955
def: "The directed movement of a cell or organism away from a source of light." [GOC:ai]
synonym: "negative phototactic behavior" EXACT []
synonym: "negative phototactic behaviour" EXACT []
synonym: "negative taxis in response to light" EXACT []
is_a: GO:0042331 ! phototaxis
is_a: GO:0052129 ! negative energy taxis

[Term]
id: GO:0046958
name: nonassociative learning
namespace: biological_process
def: "A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment." [ISBN:0582227089]
synonym: "unconditional response" EXACT []
is_a: GO:0007612 ! learning

[Term]
id: GO:0046959
name: habituation
namespace: biological_process
def: "A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089]
xref: Wikipedia:Habituation
is_a: GO:0046958 ! nonassociative learning

[Term]
id: GO:0046960
name: sensitization
namespace: biological_process
def: "An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched." [ISBN:0582227089]
xref: Wikipedia:Sensitization
is_a: GO:0046958 ! nonassociative learning

[Term]
id: GO:0046961
name: proton-transporting ATPase activity, rotational mechanism
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [EC:3.6.3.14]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
synonym: "ATP phosphohydrolase (H+-transporting) activity" EXACT [EC:3.6.3.14]
synonym: "ATP synthase activity" BROAD [EC:3.6.3.14]
synonym: "bacterial Ca2+/Mg2+ ATPase" NARROW [EC:3.6.3.14]
synonym: "chloroplast ATPase activity" NARROW [EC:3.6.3.14]
synonym: "coupling factors (Fo, F1 and CF1)" RELATED [EC:3.6.3.14]
synonym: "F(0)F(1)-ATPase activity" NARROW [EC:3.6.3.14]
synonym: "F(1)-ATPase activity" NARROW [EC:3.6.3.14]
synonym: "F(o)F(1)-ATPase activity" NARROW [EC:3.6.3.14]
synonym: "F0F1-ATPase" NARROW [EC:3.6.3.14]
synonym: "F1-ATPase" NARROW [EC:3.6.3.14]
synonym: "FoF1-ATPase" NARROW [EC:3.6.3.14]
synonym: "H(+)-transporting ATP synthase activity" EXACT [EC:3.6.3.14]
synonym: "H(+)-transporting ATPase activity" BROAD [EC:3.6.3.14]
synonym: "H+-transporting ATPase activity" EXACT [EC:3.6.3.14]
synonym: "H+-transporting two-sector ATPase" NARROW [EC:3.6.3.14]
synonym: "hydrogen ion translocating A-type ATPase activity" NARROW []
synonym: "hydrogen ion translocating F-type ATPase activity" NARROW []
synonym: "hydrogen ion translocating V-type ATPase activity" NARROW []
synonym: "hydrogen ion transporting ATPase activity, rotational mechanism" EXACT []
synonym: "hydrogen ion transporting two-sector ATPase activity" NARROW []
synonym: "mitochondrial ATPase activity" NARROW [EC:3.6.3.14]
xref: MetaCyc:ATPSYN-RXN
is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0046962
name: sodium-transporting ATPase activity, rotational mechanism
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out), by a rotational mechanism." [EC:3.6.3.15]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "ATP phosphohydrolase (Na+-transporting) activity" EXACT [EC:3.6.3.15]
synonym: "ATP synthase, sodium ion specific activity" EXACT [EC:3.6.3.145]
synonym: "Na(+)-translocating ATPase activity" BROAD [EC:3.6.3.15]
synonym: "Na(+)-transporting two-sector ATPase activity" EXACT [EC:3.6.3.15]
synonym: "Na+-translocating ATPase activity" EXACT [EC:3.6.3.15]
synonym: "Na+-translocating F1Fo-ATPase" NARROW [EC:3.6.3.15]
synonym: "Na+-transporting two-sector ATPase" NARROW [EC:3.6.3.15]
synonym: "sodium transporting ATPase activity, rotational mechanism" EXACT []
synonym: "sodium-translocating F-type ATPase activity" NARROW []
synonym: "sodium-translocating V-type ATPase activity" NARROW []
synonym: "sodium-transporting two-sector ATPase activity" NARROW []
synonym: "vacuolar-type Na+-ATPase" NARROW [EC:3.6.3.15]
synonym: "vacuolar-type Na+-translocating ATPase" NARROW [EC:3.6.3.15]
xref: MetaCyc:3.6.3.15-RXN
is_a: GO:0015081 ! sodium ion transmembrane transporter activity
is_a: GO:0019829 ! cation-transporting ATPase activity

[Term]
id: GO:0046963
name: 3'-phosphoadenosine 5'-phosphosulfate transport
namespace: biological_process
def: "The directed movement of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, into, out of, within or between cells by means of some external agent such as a transporter or pore." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "3'-phosphoadenosine 5'-phosphosulphate transport" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate transport" EXACT []
synonym: "PAPS transport" EXACT []
is_a: GO:0015860 ! purine nucleoside transport

[Term]
id: GO:0046964
name: 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "3'-phosphoadenosine 5'-phosphosulphate transporter activity" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate transmembrane transporter activity" EXACT []
synonym: "PAPS transporter activity" EXACT []
is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity

[Term]
id: GO:0046965
name: retinoid X receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a retinoid X receptor." [GOC:ai]
synonym: "RXR binding" EXACT []
is_a: GO:0042974 ! retinoic acid receptor binding

[Term]
id: GO:0046966
name: thyroid hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a thyroid hormone receptor." [GOC:ai]
synonym: "ligand-dependent thyroid hormone receptor interactor activity" NARROW []
is_a: GO:0008134 ! transcription factor binding
is_a: GO:0035257 ! nuclear hormone receptor binding

[Term]
id: GO:0046967
name: cytosol to ER transport
namespace: biological_process
def: "The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell." [GOC:ai]
synonym: "cytosol to endoplasmic reticulum transport" EXACT []
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0046968
name: peptide antigen transport
namespace: biological_process
def: "The directed movement of a peptide antigen into, out of, within or between cells by means of some external agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
is_a: GO:0015833 ! peptide transport
relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0046969
name: NAD-dependent histone deacetylase activity (H3-K9 specific)
namespace: molecular_function
def: "Catalysis of the NAD-dependent removal of an acetyl group from lysine at position 9 of the histone H3 protein." [GOC:ai]
is_a: GO:0017136 ! NAD-dependent histone deacetylase activity
is_a: GO:0032129 ! histone deacetylase activity (H3-K9 specific)

[Term]
id: GO:0046970
name: NAD-dependent histone deacetylase activity (H4-K16 specific)
namespace: molecular_function
def: "Catalysis of the removal of an acetyl group from lysine at position 16 of the histone H4 protein." [GOC:ai]
is_a: GO:0017136 ! NAD-dependent histone deacetylase activity

[Term]
id: GO:0046972
name: histone acetyltransferase activity (H4-K16 specific)
namespace: molecular_function
def: "Catalysis of the addition of an acetyl group onto lysine at position 16 of the histone H4 protein." [GOC:ai]
synonym: "histone lysine acetyltransferase activity (H4-K16 specific)" EXACT []
is_a: GO:0010485 ! H4 histone acetyltransferase activity

[Term]
id: GO:0046973
name: histone lysine N-methyltransferase activity (H3-K24 specific)
namespace: molecular_function
def: "OBSOLETE. Catalysis of the addition of a methyl group onto lysine at position 24 of the histone H3 protein." [GOC:ai]
comment: This term was made obsolete because there is no lysine at position 24 of histone H3.
is_obsolete: true
consider: GO:0042800

[Term]
id: GO:0046974
name: histone methyltransferase activity (H3-K9 specific)
namespace: molecular_function
def: "Catalysis of the addition of a methyl group onto lysine at position 9 of the histone H3 protein." [GOC:ai]
synonym: "histone lysine N-methyltransferase activity (H3-K9 specific)" EXACT []
synonym: "histone methylase activity (H3-K9 specific)" EXACT [GOC:mah]
is_a: GO:0018024 ! histone-lysine N-methyltransferase activity

[Term]
id: GO:0046975
name: histone methyltransferase activity (H3-K36 specific)
namespace: molecular_function
def: "Catalysis of the addition of a methyl group onto lysine at position 36 of the histone H3 protein." [GOC:ai]
synonym: "histone lysine N-methyltransferase activity (H3-K36 specific)" EXACT []
synonym: "histone methylase activity (H3-K36 specific)" EXACT [GOC:mah]
is_a: GO:0018024 ! histone-lysine N-methyltransferase activity

[Term]
id: GO:0046976
name: histone methyltransferase activity (H3-K27 specific)
namespace: molecular_function
def: "Catalysis of the addition of a methyl group onto lysine at position 27 of the histone H3 protein." [GOC:ai]
synonym: "histone lysine N-methyltransferase activity (H3-K27 specific)" EXACT []
synonym: "histone methylase activity (H3-K27 specific)" EXACT [GOC:mah]
is_a: GO:0018024 ! histone-lysine N-methyltransferase activity

[Term]
id: GO:0046977
name: TAP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2." [PMID:11133832]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0046978
name: TAP1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the TAP1 subunit of TAP (transporter associated with antigen processing) protein." [PMID:11133832]
is_a: GO:0046977 ! TAP binding

[Term]
id: GO:0046979
name: TAP2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the TAP2 subunit of TAP (transporter associated with antigen processing) protein." [PMID:11133832]
is_a: GO:0046977 ! TAP binding

[Term]
id: GO:0046980
name: tapasin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules." [PMID:12594855]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0046981
name: beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids." [GOC:bf, PMID:12130631, PMID:12130651]
synonym: "UDP-N-acetylglucosamine:beta-D-mannosyl-glycolipid beta-1,3-N-acetylglucosaminyltransferase activity" EXACT []
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0046982
name: protein heterodimerization activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai]
is_a: GO:0046983 ! protein dimerization activity

[Term]
id: GO:0046983
name: protein dimerization activity
namespace: molecular_function
def: "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0046984
name: regulation of hemoglobin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai]
synonym: "regulation of haemoglobin biosynthesis" EXACT []
synonym: "regulation of haemoglobin biosynthetic process" EXACT []
synonym: "regulation of hemoglobin anabolism" EXACT []
synonym: "regulation of hemoglobin biosynthesis" EXACT []
synonym: "regulation of hemoglobin formation" EXACT []
synonym: "regulation of hemoglobin synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: regulates GO:0042541 ! hemoglobin biosynthetic process

[Term]
id: GO:0046985
name: positive regulation of hemoglobin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai]
synonym: "activation of hemoglobin biosynthetic process" NARROW []
synonym: "positive regulation of haemoglobin biosynthesis" EXACT []
synonym: "positive regulation of haemoglobin biosynthetic process" EXACT []
synonym: "positive regulation of hemoglobin anabolism" EXACT []
synonym: "positive regulation of hemoglobin biosynthesis" EXACT []
synonym: "positive regulation of hemoglobin formation" EXACT []
synonym: "positive regulation of hemoglobin synthesis" EXACT []
synonym: "stimulation of hemoglobin biosynthetic process" NARROW []
synonym: "up regulation of hemoglobin biosynthetic process" EXACT []
synonym: "up-regulation of hemoglobin biosynthetic process" EXACT []
synonym: "upregulation of hemoglobin biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0046984 ! regulation of hemoglobin biosynthetic process
is_a: GO:0051247 ! positive regulation of protein metabolic process
relationship: positively_regulates GO:0042541 ! hemoglobin biosynthetic process

[Term]
id: GO:0046986
name: negative regulation of hemoglobin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai]
synonym: "down regulation of hemoglobin biosynthetic process" EXACT []
synonym: "down-regulation of hemoglobin biosynthetic process" EXACT []
synonym: "downregulation of hemoglobin biosynthetic process" EXACT []
synonym: "inhibition of hemoglobin biosynthetic process" NARROW []
synonym: "negative regulation of haemoglobin biosynthesis" EXACT []
synonym: "negative regulation of haemoglobin biosynthetic process" EXACT []
synonym: "negative regulation of hemoglobin anabolism" EXACT []
synonym: "negative regulation of hemoglobin biosynthesis" EXACT []
synonym: "negative regulation of hemoglobin formation" EXACT []
synonym: "negative regulation of hemoglobin synthesis" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0046984 ! regulation of hemoglobin biosynthetic process
is_a: GO:0051248 ! negative regulation of protein metabolic process
relationship: negatively_regulates GO:0042541 ! hemoglobin biosynthetic process

[Term]
id: GO:0046987
name: N-acetyllactosamine beta-1,3-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine)." [GOC:bf, PMID:12511570]
synonym: "galactosyl beta-1,4 N-acetylglucosamine beta-1,3 glucuronosyltransferase activity" EXACT []
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0046988
name: asioloorosomucoid beta-1,3-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid." [GOC:bf, PMID:12511570]
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0046989
name: galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids." [GOC:bf, PMID:12511570]
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0046990
name: N-hydroxyarylamine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine." [EC:2.3.1.118, MetaCyc:2.3.1.118-RXN]
subset: gosubset_prok
synonym: "acetyl-CoA:N-hydroxyarylamine O-acetyltransferase activity" EXACT [EC:2.3.1.118]
synonym: "arylhydroxamate N,O-acetyltransferase activity" EXACT [EC:2.3.1.118]
synonym: "N-hydroxy-2-aminofluorene-O-acetyltransferase activity" EXACT [EC:2.3.1.118]
xref: EC:2.3.1.118
xref: MetaCyc:2.3.1.118-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0046992
name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y." [GOC:ai]
comment: Note that enzymes of class EC:1.21.99.- should also be annotated to this term.
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors" NARROW []
xref: EC:1.21
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0046993
name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen." [GOC:ai]
subset: gosubset_prok
xref: EC:1.21.3
is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond

[Term]
id: GO:0046994
name: oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound." [GOC:jl]
subset: gosubset_prok
xref: EC:1.12.5
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0046995
name: oxidoreductase activity, acting on hydrogen as donor, with other known acceptors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound." [GOC:ai]
subset: gosubset_prok
xref: EC:1.12.98
is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor

[Term]
id: GO:0046996
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and the latter donor is dehydrogenated." [GOC:mah]
xref: EC:1.14.21
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0046997
name: oxidoreductase activity, acting on the CH-NH group of donors, with a flavin as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin." [GOC:jl]
subset: gosubset_prok
xref: EC:1.5.8
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0046998
name: (S)-usnate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-usnic acid + NADH + H+ = NAD+ + 2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methyl-phenyl)-3-hydroxy-6-methyl-cyclohexa-2,4-dienone." [EC:1.1.1.199, MetaCyc:1.1.1.199-RXN]
synonym: "L-usnic acid dehydrogenase activity" EXACT [EC:1.1.1.199]
synonym: "reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming)" EXACT [EC:1.1.1.199]
xref: EC:1.1.1.199
xref: MetaCyc:1.1.1.199-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0046999
name: regulation of conjugation
namespace: biological_process
def: "Any process that modulates the rate or frequency of conjugation, the union or introduction of genetic information from compatible mating types that results in a genetically different individual." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043900 ! regulation of multi-organism process
relationship: regulates GO:0000746 ! conjugation

[Term]
id: GO:0047000
name: 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 2-dehydro-3-deoxy-D-gluconate = NADPH + H+ + (4S,5S)-4,5-dehydroxy-2,6-dioxohexanoate." [EC:1.1.1.126, MetaCyc:1.1.1.126-RXN]
synonym: "2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.126]
synonym: "2-keto-3-deoxy-D-gluconate dehydrogenase activity" EXACT [EC:1.1.1.126]
xref: EC:1.1.1.126
xref: MetaCyc:1.1.1.126-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047001
name: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate." [EC:1.1.1.127, MetaCyc:1.1.1.127-RXN]
synonym: "2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.127]
synonym: "2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase activity" EXACT [EC:1.1.1.127]
synonym: "2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity" EXACT [EC:1.1.1.127]
synonym: "2-keto-3-deoxygluconate 5-dehydrogenase activity" EXACT [EC:1.1.1.127]
synonym: "2-keto-3-deoxygluconate dehydrogenase activity" EXACT [EC:1.1.1.127]
xref: EC:1.1.1.127
xref: MetaCyc:1.1.1.127-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047002
name: L-arabinitol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + L-arabitol = NADH + H+ + L-ribulose." [EC:1.1.1.13, MetaCyc:1.1.1.13-RXN]
synonym: "L-arabinitol 2-dehydrogenase (ribulose forming) activity" EXACT []
xref: EC:1.1.1.13
xref: MetaCyc:1.1.1.13-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047003
name: dTDP-6-deoxy-L-talose 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + dTDP-6-deoxy-L-talose = NADPH + dTDP-4-dehydro-6-deoxy-L-mannose." [EC:1.1.1.134, MetaCyc:1.1.1.134-RXN]
synonym: "dTDP-6-deoxy-L-talose dehydrogenase (4-reductase)" EXACT [EC:1.1.1.134]
synonym: "dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.134]
synonym: "TDP-6-deoxy-L-talose dehydrogenase activity" EXACT [EC:1.1.1.134]
synonym: "thymidine diphospho-6-deoxy-L-talose dehydrogenase activity" EXACT [EC:1.1.1.134]
xref: EC:1.1.1.134
xref: MetaCyc:1.1.1.134-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047004
name: UDP-N-acetylglucosamine 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 2 NAD+ + UDP-N-acetyl-D-glucosamine = 2 NADH + 2 H+ + UDP-N-acetyl-2-amino-d-glucuronate." [EC:1.1.1.136, MetaCyc:1.1.1.136-RXN]
synonym: "UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase activity" EXACT [EC:1.1.1.136]
synonym: "UDP-GLcNAc dehydrogenase activity" EXACT [EC:1.1.1.136]
synonym: "UDP-N-acetyl-D-glucosamine:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.136]
synonym: "UDPacetylglucosamine dehydrogenase activity" EXACT [EC:1.1.1.136]
synonym: "uridine diphosphoacetylglucosamine dehydrogenase activity" EXACT [EC:1.1.1.136]
xref: EC:1.1.1.136
xref: MetaCyc:1.1.1.136-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047005
name: 16-alpha-hydroxysteroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid." [EC:1.1.1.147, MetaCyc:1.1.1.147-RXN]
synonym: "16alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.147]
synonym: "16alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.147]
synonym: "16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase activity" EXACT [EC:1.1.1.147]
xref: EC:1.1.1.147
xref: MetaCyc:1.1.1.147-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047006
name: 20-alpha-hydroxysteroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone." [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN]
subset: gosubset_prok
synonym: "20alpha-HSD" RELATED [EC:1.1.1.149]
synonym: "20alpha-HSDH" RELATED [EC:1.1.1.149]
synonym: "20alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.149]
synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.149]
synonym: "20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity" EXACT [EC:1.1.1.149]
xref: EC:1.1.1.149
xref: MetaCyc:1.1.1.149-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047007
name: 21-hydroxysteroid dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + pregnan-21-ol = NADH + H+ + pregnan-21-al." [EC:1.1.1.150, MetaCyc:1.1.1.150-RXN]
synonym: "21-hydroxysteroid:NAD+ 21-oxidoreductase activity" EXACT [EC:1.1.1.150]
xref: EC:1.1.1.150
xref: MetaCyc:1.1.1.150-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047008
name: 21-hydroxysteroid dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + pregnan-21-ol = NADPH + H+ + pregnan-21-al." [EC:1.1.1.151, MetaCyc:1.1.1.151-RXN]
synonym: "21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.151]
synonym: "21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity" EXACT [EC:1.1.1.151]
synonym: "21-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.151]
synonym: "21-hydroxysteroid:NADP+ 21-oxidoreductase activity" EXACT [EC:1.1.1.151]
synonym: "NADP-21-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.151]
xref: EC:1.1.1.151
xref: MetaCyc:1.1.1.151-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047009
name: 3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione." [EC:1.1.1.152, MetaCyc:1.1.1.152-RXN]
synonym: "3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase activity" EXACT [EC:1.1.1.152]
synonym: "3alpha-hydroxy-5beta-steroid dehydrogenase activity" EXACT [EC:1.1.1.152]
synonym: "3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.152]
synonym: "etiocholanolone 3-alpha-dehydrogenase activity" EXACT [EC:1.1.1.152]
synonym: "etiocholanolone 3alpha-dehydrogenase activity" EXACT [EC:1.1.1.152]
xref: EC:1.1.1.152
xref: MetaCyc:1.1.1.152-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047010
name: hydroxycyclohexanecarboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate = NADH + H+ + (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate." [EC:1.1.1.166, MetaCyc:1.1.1.166-RXN]
synonym: "(-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD oxidoreductase activity" EXACT [EC:1.1.1.166]
synonym: "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.166]
synonym: "dihydroxycyclohexanecarboxylate dehydrogenase activity" EXACT [EC:1.1.1.166]
xref: EC:1.1.1.166
xref: MetaCyc:1.1.1.166-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047011
name: 2-dehydropantolactone reductase (A-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.168, MetaCyc:1.1.1.168-RXN]
synonym: "(R)-pantolactone:NADP+ oxidoreductase (A-specific)" EXACT [EC:1.1.1.168]
synonym: "2-dehydropantoyl-lactone reductase (A-specific) activity" EXACT [EC:1.1.1.168]
synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.168]
synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.168]
synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.168]
xref: EC:1.1.1.168
xref: MetaCyc:1.1.1.168-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047012
name: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one." [EC:1.1.1.170, MetaCyc:1.1.1.170-RXN]
synonym: "3-beta-hydroxy-4-alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity" EXACT []
synonym: "3-beta-hydroxy-4-beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity" RELATED [EC:1.1.1.170]
synonym: "3-beta-hydroxy-4-beta-methylcholestenoate dehydrogenase activity" RELATED [EC:1.1.1.170]
synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170]
synonym: "sterol 4-alpha-carboxylic decarboxylase activity" RELATED [EC:1.1.1.170]
xref: EC:1.1.1.170
xref: MetaCyc:1.1.1.170-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047013
name: 12-alpha-hydroxysteroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate = NADPH + H+ + 3-alpha,7-alpha-dihydroxy-12-oxo-5-beta-cholanate." [EC:1.1.1.176, MetaCyc:1.1.1.176-RXN]
subset: gosubset_prok
synonym: "12alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.176]
synonym: "12alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.176]
synonym: "12alpha-hydroxysteroid:NADP+ 12-oxidoreductase activity" EXACT [EC:1.1.1.176]
synonym: "NAD-dependent 12alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.176]
synonym: "NADP-12alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.176]
xref: EC:1.1.1.176
xref: MetaCyc:1.1.1.176-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047014
name: glycerol-3-phosphate 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + glycerol-3-phosphate = NADPH + H+ + glyceraldehyde-3-phosphate." [EC:1.1.1.177, MetaCyc:1.1.1.177-RXN]
synonym: "glycerin-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.177]
synonym: "glycerol phosphate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.177]
synonym: "L-glycerol 3-phosphate:NADP oxidoreductase activity" EXACT [EC:1.1.1.177]
synonym: "NADPH-dependent glycerin-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.177]
synonym: "sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.177]
xref: EC:1.1.1.177
xref: MetaCyc:1.1.1.177-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047015
name: 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA." [EC:1.1.1.178, MetaCyc:1.1.1.178-RXN]
synonym: "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.178]
synonym: "2-methyl-3-hydroxy-butyryl CoA dehydrogenase activity" EXACT [EC:1.1.1.178]
synonym: "2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.178]
synonym: "2-methyl-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.178]
xref: EC:1.1.1.178
xref: MetaCyc:1.1.1.178-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047016
name: cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one." [EC:1.1.1.181, MetaCyc:1.1.1.181-RXN]
synonym: "3-beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase activity" EXACT [EC:1.1.1.181]
synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.181]
synonym: "cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase activity" EXACT [EC:1.1.1.181]
synonym: "cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.181]
xref: EC:1.1.1.181
xref: MetaCyc:1.1.1.181-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047017
name: prostaglandin-F synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate." [EC:1.1.1.188, MetaCyc:1.1.1.188-RXN]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase activity" EXACT [EC:1.1.1.188]
synonym: "NADPH-dependent prostaglandin D2 11-keto reductase activity" EXACT [EC:1.1.1.188]
synonym: "PGD(2) 11-ketoreductase activity" EXACT [EC:1.1.1.188]
synonym: "PGD2 11-ketoreductase activity" EXACT [EC:1.1.1.188]
synonym: "PGF synthetase activity" EXACT [EC:1.1.1.188]
synonym: "PGF2alpha synthetase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin 11-keto reductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin 11-ketoreductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin D2-ketoreductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin F synthase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin F synthetase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin-D(2) 11-ketoreductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin-D(2) 11-reductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin-D(2) ketoreductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin-D2 11-ketoreductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin-D2 11-reductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin-D2 ketoreductase activity" EXACT [EC:1.1.1.188]
synonym: "prostaglandin-F synthetase activity" EXACT [EC:1.1.1.188]
synonym: "reductase, 15-hydroxy-11-oxoprostaglandin" EXACT [EC:1.1.1.188]
synonym: "synthetase, prostaglandin F2alpha" EXACT [EC:1.1.1.188]
xref: EC:1.1.1.188
xref: MetaCyc:1.1.1.188-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047018
name: indole-3-acetaldehyde reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + indole-3-ethanol = NADH + H+ + indole acetaldehyde." [EC:1.1.1.190, MetaCyc:1.1.1.190-RXN]
synonym: "(indol-3-yl)ethanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.190]
synonym: "indole-3-ethanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.190]
synonym: "indoleacetaldehyde reductase activity" EXACT [EC:1.1.1.190]
xref: EC:1.1.1.190
xref: MetaCyc:1.1.1.190-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047019
name: indole-3-acetaldehyde reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + indole-3-ethanol = NADPH + H+ + indole acetaldehyde." [EC:1.1.1.191, MetaCyc:1.1.1.191-RXN]
synonym: "(indol-3-yl)ethanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.191]
synonym: "indole-3-ethanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.191]
synonym: "indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.191]
xref: EC:1.1.1.191
xref: MetaCyc:1.1.1.191-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047020
name: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate." [EC:1.1.1.196, MetaCyc:1.1.1.196-RXN]
synonym: "(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.196]
synonym: "15-hydroxy PGD2 dehydrogenase activity" EXACT [EC:1.1.1.196]
synonym: "15-hydroxyprostaglandin dehydrogenase (NADP)" EXACT [EC:1.1.1.196]
synonym: "dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.196]
synonym: "dehydrogenase, prostaglandin D2" EXACT [EC:1.1.1.196]
synonym: "NADP-dependent 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196]
synonym: "NADP-linked 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196]
synonym: "NADP-linked prostaglandin D2 dehydrogenase activity" EXACT [EC:1.1.1.196]
synonym: "NADP-PGD2 dehydrogenase activity" EXACT [EC:1.1.1.196]
synonym: "NADP-specific 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196]
synonym: "prostaglandin D2 dehydrogenase activity" EXACT [EC:1.1.1.196]
synonym: "prostaglandin-D 15-dehydrogenase (NADP(+)) activity" EXACT [EC:1.1.1.196]
synonym: "prostaglandin-D 15-dehydrogenase (NADP)" EXACT [EC:1.1.1.196]
synonym: "prostaglandin-D 15-dehydrogenase (NADP+) activity" EXACT [EC:1.1.1.196]
xref: EC:1.1.1.196
xref: MetaCyc:1.1.1.196-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047021
name: 15-hydroxyprostaglandin dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate = NADPH + H+ + (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate." [EC:1.1.1.197, MetaCyc:1.1.1.197-RXN]
synonym: "(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.197]
synonym: "NADP-dependent 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197]
synonym: "NADP-linked 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197]
synonym: "NADP-specific 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197]
synonym: "type II 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.197]
xref: EC:1.1.1.197
xref: MetaCyc:1.1.1.197-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047022
name: 7-beta-hydroxysteroid dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 7-beta-hydroxysteroid = NADPH + H+ + 7-oxosteroid." [EC:1.1.1.201, MetaCyc:1.1.1.201-RXN]
synonym: "7beta-hydroxysteroid dehydrogenase (NADP+)" EXACT [EC:1.1.1.201]
synonym: "7beta-hydroxysteroid:NADP+ 7-oxidoreductase activity" EXACT [EC:1.1.1.201]
synonym: "NADP-dependent 7-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.201]
synonym: "NADP-dependent 7beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.201]
xref: EC:1.1.1.201
xref: MetaCyc:1.1.1.201-RXN
xref: Wikipedia:7beta-hydroxysteroid_dehydrogenase_(NADP+)
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047023
name: 3(or 17)-alpha-hydroxysteroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione." [EC:1.1.1.209, MetaCyc:1.1.1.209-RXN]
synonym: "3(17)alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.209]
synonym: "3(or 17)alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.209]
synonym: "3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.209]
xref: EC:1.1.1.209
xref: MetaCyc:1.1.1.209-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047024
name: 3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 5-alpha-androstan-3-beta,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADPH + H+." [EC:1.1.1.210, MetaCyc:1.1.1.210-RXN]
synonym: "3-beta-HSD activity" EXACT [EC:1.1.1.210]
synonym: "3beta(or 20alpha)-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.210]
synonym: "3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.210]
synonym: "3beta,20alpha-hydroxysteroid oxidoreductase activity" EXACT [EC:1.1.1.210]
synonym: "dehydrogenase, 3beta,20alpha-hydroxy steroid" EXACT [EC:1.1.1.210]
synonym: "progesterone reductase activity" BROAD [EC:1.1.1.210]
xref: EC:1.1.1.210
xref: MetaCyc:1.1.1.210-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047025
name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]." [EC:1.1.1.212, MetaCyc:1.1.1.212-RXN]
synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.212]
synonym: "3-oxoacyl-[acyl-carrier protein] reductase (NADH) activity" EXACT []
synonym: "3-oxoacyl-ACP reductase (NADH) activity" EXACT []
synonym: "3-oxoacyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.1.1.212]
synonym: "3-oxoacyl-acyl-carrier-protein reductase (NADH)" EXACT [EC:1.1.1.212]
xref: EC:1.1.1.212
xref: MetaCyc:1.1.1.212-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047026
name: 3-alpha-hydroxysteroid dehydrogenase (A-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+." [EC:1.1.1.213, MetaCyc:1.1.1.213-RXN]
synonym: "3alpha-hydroxysteroid dehydrogenase (A-specific)" EXACT [EC:1.1.1.213]
synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific)" EXACT [EC:1.1.1.213]
xref: EC:1.1.1.213
xref: MetaCyc:1.1.1.213-RXN
xref: Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(A-specific)
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047027
name: benzyl-2-methyl-hydroxybutyrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + benzyl (2R,3S)-2-methyl-3-hydroxybutanoate = NADPH + H+ + benzyl 2-methyl-3-oxobutanoate." [EC:1.1.1.217, MetaCyc:1.1.1.217-RXN]
synonym: "benzyl 2-methyl-3-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.217]
synonym: "benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.217]
xref: EC:1.1.1.217
xref: MetaCyc:1.1.1.217-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047028
name: 6-pyruvoyltetrahydropterin 2'-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin." [EC:1.1.1.220, MetaCyc:1.1.1.220-RXN]
subset: gosubset_prok
synonym: "6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.1.1.220]
synonym: "6-pyruvoyl tetrahydropterin (2'-oxo)reductase activity" EXACT [EC:1.1.1.220]
synonym: "6-pyruvoyl-tetrahydropterin 2'-reductase activity" EXACT [EC:1.1.1.220]
synonym: "6-pyruvoyltetrahydropterin reductase activity" EXACT [EC:1.1.1.220]
synonym: "6PPH4(2'-oxo) reductase activity" EXACT [EC:1.1.1.220]
synonym: "pyruvoyl-tetrahydropterin reductase activity" EXACT [EC:1.1.1.220]
xref: EC:1.1.1.220
xref: MetaCyc:1.1.1.220-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047029
name: (R)-4-hydroxyphenyllactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + (R)-3-(4-hydroxyphenyl)lactate = NAD(P)H + H+ + 3-(4-hydroxyphenyl)pyruvate." [EC:1.1.1.222, MetaCyc:1.1.1.222-RXN]
synonym: "(R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.222]
synonym: "(R)-aromatic lactate dehydrogenase activity" EXACT [EC:1.1.1.222]
synonym: "D-hydrogenase, D-aryllactate" EXACT [EC:1.1.1.222]
xref: EC:1.1.1.222
xref: MetaCyc:1.1.1.222-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047030
name: 4-hydroxycyclohexanecarboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 4-hydroxycyclohexanecarboxylate = NADH + H+ + 4-oxocyclohexanecarboxylate." [EC:1.1.1.226, MetaCyc:1.1.1.226-RXN]
synonym: "trans-4-hydroxycyclohexanecarboxylate dehydrogenase activity" EXACT [EC:1.1.1.226]
synonym: "trans-4-hydroxycyclohexanecarboxylate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.226]
xref: EC:1.1.1.226
xref: MetaCyc:1.1.1.226-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047031
name: diethyl 2-methyl-3-oxosuccinate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + diethyl (2R,3R)-2-methyl-3-hydroxysuccinate = NADPH + H+ + diethyl-2-methyl-3-oxosuccinate." [EC:1.1.1.229, MetaCyc:1.1.1.229-RXN]
synonym: "diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.229]
xref: EC:1.1.1.229
xref: MetaCyc:1.1.1.229-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047032
name: 3-alpha-hydroxyglycyrrhetinate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 3-alpha-hydroxyglycyrrhetinate = NADPH + H+ + 3-oxoglycyrrhetinate." [EC:1.1.1.230, MetaCyc:1.1.1.230-RXN]
synonym: "3alpha-hydroxyglycyrrhetinate dehydrogenase activity" EXACT [EC:1.1.1.230]
synonym: "3alpha-hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.230]
xref: EC:1.1.1.230
xref: MetaCyc:1.1.1.230-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047033
name: 15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-6,9-alpha-epoxy-11-alpha-hydroxy-15-oxoprosta-5,13-dienoate." [EC:1.1.1.231, MetaCyc:1.1.1.231-RXN]
synonym: "(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity" EXACT [EC:1.1.1.231]
synonym: "NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.231]
synonym: "NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase activity" EXACT [EC:1.1.1.231]
synonym: "PG I2 dehydrogenase activity" EXACT [EC:1.1.1.231]
synonym: "prostacyclin dehydrogenase activity" EXACT [EC:1.1.1.231]
xref: EC:1.1.1.231
xref: MetaCyc:1.1.1.231-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047034
name: 15-hydroxyicosatetraenoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate." [EC:1.1.1.232, MetaCyc:1.1.1.232-RXN]
synonym: "(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase activity" EXACT [EC:1.1.1.232]
synonym: "15-hydroxyeicosatetraenoate dehydrogenase activity" EXACT [EC:1.1.1.232]
xref: EC:1.1.1.232
xref: MetaCyc:1.1.1.232-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047035
name: 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + testosterone = NADH + H+ + androst-4-ene-3,17-dione." [EC:1.1.1.239, MetaCyc:1.1.1.239-RXN]
synonym: "3alpha(17beta)-HSD" RELATED [EC:1.1.1.239]
synonym: "3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)" EXACT [EC:1.1.1.239]
synonym: "3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.239]
synonym: "3alpha,17beta-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.239]
xref: EC:1.1.1.239
xref: MetaCyc:1.1.1.239-RXN
xref: Wikipedia:3alpha(17beta)-hydroxysteroid_dehydrogenase_(NAD+)
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047036
name: codeinone reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + codeine = NADPH + H+ + codeinone." [EC:1.1.1.247, MetaCyc:1.1.1.247-RXN]
synonym: "codeine:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.247]
xref: EC:1.1.1.247
xref: MetaCyc:1.1.1.247-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047037
name: salutaridine reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + salutaridinol = NADPH + H+ + salutaridine." [EC:1.1.1.248, MetaCyc:1.1.1.248-RXN]
synonym: "salutaridinol:NADP+ 7-oxidoreductase activity" EXACT [EC:1.1.1.248]
xref: EC:1.1.1.248
xref: MetaCyc:1.1.1.248-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047038
name: D-arabinitol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + D-arabitol = NADH + H+ + D-ribulose." [EC:1.1.1.250, MetaCyc:1.1.1.250-RXN]
synonym: "D-arabinitol 2-dehydrogenase (ribulose-forming) activity" EXACT [EC:1.1.1.250]
synonym: "D-arabinitol:NAD+ 2-oxidoreductase (D-ribulose-forming)" EXACT [EC:1.1.1.250]
xref: EC:1.1.1.250
xref: MetaCyc:1.1.1.250-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047039
name: tetrahydroxynaphthalene reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol." [EC:1.1.1.252, MetaCyc:1.1.1.252-RXN]
synonym: "scytalone:NADP+ delta5-oxidoreductase activity" EXACT [EC:1.1.1.252]
synonym: "T4HN reductase activity" EXACT [EC:1.1.1.252]
xref: EC:1.1.1.252
xref: MetaCyc:1.1.1.252-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047040
name: pteridine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 NADP+ + tetra-hydro-biopterin = 2 NADPH + 2 H+ + biopterin." [EC:1.1.1.253, MetaCyc:1.1.1.253-RXN]
comment: Note that this function was formerly EC:1.1.1.253.
synonym: "5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.33]
synonym: "dihydrobiopterin reduction" RELATED []
synonym: "pteridine reductase 1 activity" NARROW [EC:1.5.1.33e]
synonym: "PTR1" RELATED [EC:1.5.1.33]
synonym: "ptr1 activity" NARROW [EC:1.5.1.33e]
xref: EC:1.5.1.33
xref: MetaCyc:1.1.1.253-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047041
name: (S)-carnitine 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + L-carnitine = NADH + H+ + 3-dehydrocarnitine." [EC:1.1.1.254, MetaCyc:1.1.1.254-RXN]
synonym: "(S)-carnitine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.254]
synonym: "D-carnitine dehydrogenase activity" EXACT [EC:1.1.1.254]
xref: EC:1.1.1.254
xref: MetaCyc:1.1.1.254-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047042
name: 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+." [EC:1.1.1.50, MetaCyc:1.1.1.50-RXN]
subset: gosubset_prok
synonym: "3-alpha-HSD activity" EXACT [EC:1.1.1.50]
synonym: "3alpha-HSD" RELATED [EC:1.1.1.50]
synonym: "3alpha-hydroxysteroid dehydrogenase (B-specific)" EXACT [EC:1.1.1.50]
synonym: "3alpha-hydroxysteroid oxidoreductase activity" EXACT [EC:1.1.1.50]
synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific)" EXACT [EC:1.1.1.50]
synonym: "hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.50]
synonym: "sterognost 3alpha" RELATED [EC:1.1.1.50]
xref: EC:1.1.1.50
xref: MetaCyc:1.1.1.50-RXN
xref: Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(B-specific)
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047043
name: 3-alpha-hydroxycholanate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-cholanate = NADH + H+ + 3-oxo-5-beta-cholanate." [EC:1.1.1.52, MetaCyc:1.1.1.52-RXN]
synonym: "3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.52]
synonym: "3alpha-hydroxycholanate dehydrogenase activity" EXACT [EC:1.1.1.52]
synonym: "alpha-hydroxy-cholanate dehydrogenase activity" EXACT [EC:1.1.1.52]
xref: EC:1.1.1.52
xref: MetaCyc:1.1.1.52-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047044
name: 3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+." [EC:1.1.1.53, MetaCyc:1.1.1.53-RXN]
subset: gosubset_prok
synonym: "(R)-20-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.53]
synonym: "20beta-HSD" RELATED [EC:1.1.1.53]
synonym: "20beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.53]
synonym: "3alpha(or 20beta)-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.53]
synonym: "3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.53]
synonym: "3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase activity" EXACT [EC:1.1.1.53]
synonym: "cortisone reductase activity" EXACT [EC:1.1.1.53]
synonym: "dehydrogenase, 20beta-hydroxy steroid" EXACT [EC:1.1.1.53]
synonym: "delta4-3-ketosteroid hydrogenase activity" EXACT [EC:1.1.1.53]
synonym: "NADH-20beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.53]
xref: EC:1.1.1.53
xref: MetaCyc:1.1.1.53-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047045
name: testosterone 17-beta-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione." [EC:1.1.1.64, MetaCyc:1.1.1.64-RXN]
synonym: "17-ketoreductase activity" BROAD [EC:1.1.1.64]
synonym: "17beta-hydroxysteroid:NADP+ 17-oxidoreductase activity" EXACT [EC:1.1.1.64]
synonym: "NADP-dependent testosterone-17beta-oxidoreductase activity" EXACT [EC:1.1.1.64]
synonym: "testosterone 17beta-dehydrogenase (NADP+)" EXACT [EC:1.1.1.64]
xref: EC:1.1.1.64
xref: MetaCyc:1.1.1.64-RXN
xref: Wikipedia:Testosterone_17beta-dehydrogenase_(NADP+)
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047046
name: homoisocitrate dehydrogenase activity
namespace: molecular_function
alt_id: GO:0047984
def: "Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate." [EC:1.1.1.155, EC:1.1.1.87, MetaCyc:1.1.1.87-RXN]
comment: Note that EC:1.1.1.155 was merged into EC:1.1.1.87 as they are identical.
synonym: "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.87]
synonym: "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87]
synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87]
synonym: "2-hydroxy-3-carboxyadipate dehydrogenase activity" EXACT [EC:1.1.1.87]
synonym: "3-carboxy-2-hydroxyadipate dehydrogenase activity" EXACT []
synonym: "3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity" EXACT [EC:1.1.1.87]
synonym: "3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.87]
synonym: "homoisocitric dehydrogenase activity" EXACT [EC:1.1.1.87]
xref: EC:1.1.1.87
xref: MetaCyc:1.1.1.87-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047047
name: oxaloglycolate reductase (decarboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate." [EC:1.1.1.92, MetaCyc:1.1.1.92-RXN]
synonym: "D-glycerate:NAD(P)+ oxidoreductase (carboxylating)" EXACT [EC:1.1.1.92]
xref: EC:1.1.1.92
xref: MetaCyc:1.1.1.92-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047048
name: 3-hydroxybenzyl-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 3-hydroxybenzyl alcohol = NADPH + H+ + 3-hydroxybenzaldehyde." [EC:1.1.1.97, MetaCyc:1.1.1.97-RXN]
synonym: "3-hydroxybenzyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.97]
synonym: "m-hydroxybenzyl alcohol (NADP) dehydrogenase activity" EXACT [EC:1.1.1.97]
synonym: "m-hydroxybenzyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.97]
synonym: "m-hydroxybenzylalcohol dehydrogenase activity" EXACT [EC:1.1.1.97]
xref: EC:1.1.1.97
xref: MetaCyc:1.1.1.97-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047049
name: (R)-2-hydroxy-fatty-acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + R-2-hydroxystearate = NADH + H+ + 2-oxostearate." [EC:1.1.1.98, MetaCyc:1.1.1.98-RXN]
synonym: "(R)-2-hydroxystearate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.98]
synonym: "2-hydroxy fatty acid oxidase" BROAD [EC:1.1.1.98]
synonym: "D-2-hydroxy fatty acid dehydrogenase activity" EXACT [EC:1.1.1.98]
xref: EC:1.1.1.98
xref: MetaCyc:1.1.1.98-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047050
name: (S)-2-hydroxy-fatty-acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + (S)-2-hydroxystearate = NADH + H+ + 2-oxostearate." [EC:1.1.1.99, MetaCyc:1.1.1.99-RXN]
synonym: "(S)-2-hydroxystearate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.99]
synonym: "2-hydroxy fatty acid oxidase" BROAD [EC:1.1.1.99]
synonym: "dehydrogenase, L-2-hydroxy fatty acid" EXACT [EC:1.1.1.99]
synonym: "L-2-hydroxy fatty acid dehydrogenase activity" EXACT [EC:1.1.1.99]
xref: EC:1.1.1.99
xref: MetaCyc:1.1.1.99-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047051
name: D-lactate dehydrogenase (cytochrome c-553) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 ferricytochrome C-553 + D-lactate = 2 ferrocytochrome C-553 + pyruvate." [EC:1.1.2.5, MetaCyc:1.1.2.5-RXN]
synonym: "(R)-lactate:ferricytochrome-c-553 2-oxidoreductase activity" EXACT [EC:1.1.2.5]
xref: EC:1.1.2.5
xref: MetaCyc:1.1.2.5-RXN
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0047052
name: (S)-stylopine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + S-cheilanthifoline = 2 H2O + NADP+ + S-stylopine." [EC:1.14.21.1, MetaCyc:1.1.3.32-RXN]
synonym: "(S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming) activity" EXACT [EC:1.14.21.1]
synonym: "(S)-cheilanthifoline,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.21.1]
xref: EC:1.14.21.1
xref: MetaCyc:1.1.3.32-RXN
is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated

[Term]
id: GO:0047053
name: (S)-cheilanthifoline synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + S-scoulerine = 2 H2O + NADP+ + S-cheilanthifoline." [EC:1.14.21.2, MetaCyc:1.14.21.2-RXN]
synonym: "(S)-scoulerine oxidase (methylenedioxy-bridge-forming) activity" EXACT []
synonym: "(S)-scoulerine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.21.2]
xref: EC:1.14.21.2
xref: MetaCyc:1.14.21.2-RXN
is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated

[Term]
id: GO:0047054
name: berbamunine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + R-N-methylcoclaurine + S-N-methylcoclaurine = 2 H2O + NADP+ + berbamunine." [EC:1.14.21.3, MetaCyc:1.1.3.34-RXN]
synonym: "(S)-N-methylcoclaurine oxidase (C-O phenol-coupling) activity" EXACT [EC:1.14.21.3]
synonym: "(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (C-O phenol-coupling)" EXACT [EC:1.14.21.3]
xref: EC:1.14.21.3
xref: MetaCyc:1.1.3.34-RXN
is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated

[Term]
id: GO:0047055
name: salutaridine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + (R)-reticuline = 2 H2O + NADP+ + salutaridine." [EC:1.14.21.4, MetaCyc:1.1.3.35-RXN]
synonym: "(R)-reticuline oxidase (C-C phenol-coupling) activity" EXACT [EC:1.14.21.4]
synonym: "(R)-reticuline,NADPH:oxygen oxidoreductase (C-C phenol-coupling)" EXACT [EC:1.14.21.4]
xref: EC:1.14.21.4
xref: MetaCyc:1.1.3.35-RXN
is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated

[Term]
id: GO:0047056
name: (S)-canadine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + S-tetrahydrocolumbamine = 2 H2O + NADP+ + S-canadine." [EC:1.14.21.5, MetaCyc:1.1.3.36-RXN]
synonym: "(S)-tetrahydroberberine synthase activity" EXACT [EC:1.14.21.5]
synonym: "(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming) activity" EXACT [EC:1.14.21.5]
synonym: "(S)-tetrahydrocolumbamine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" EXACT [EC:1.14.21.5]
xref: EC:1.14.21.5
xref: MetaCyc:1.1.3.36-RXN
is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated

[Term]
id: GO:0047057
name: vitamin-K-epoxide reductase (warfarin-sensitive) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [EC:1.1.4.1, MetaCyc:1.1.4.1-RXN]
synonym: "2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity" EXACT [EC:1.1.4.1]
synonym: "phylloquinone epoxide reductase activity" EXACT [EC:1.1.4.1]
synonym: "vitamin K1 epoxide reductase activity" NARROW [EC:1.1.4.1]
xref: EC:1.1.4.1
xref: MetaCyc:1.1.4.1-RXN
xref: Reactome:82285 "vitamin-K-epoxide reductase (warfarin-sensitive) activity"
is_a: GO:0016900 ! oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor

[Term]
id: GO:0047058
name: vitamin-K-epoxide reductase (warfarin-insensitive) activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [EC:1.1.4.2, MetaCyc:1.1.4.2-RXN]
synonym: "3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity" EXACT [EC:1.1.4.2]
synonym: "vitamin K 2,3-epoxide reductase activity" EXACT [EC:1.1.4.2]
xref: EC:1.1.4.2
xref: MetaCyc:1.1.4.2-RXN
is_a: GO:0016900 ! oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor

[Term]
id: GO:0047059
name: polyvinyl-alcohol dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: acceptor + polyvinyl alcohol = donor-H2 + oxidized polyvinyl alcohol." [EC:1.1.99.23, MetaCyc:1.1.99.23-RXN]
subset: gosubset_prok
synonym: "polyvinyl-alcohol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.23]
synonym: "polyvinyl-alcohol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.23]
synonym: "PVA dehydrogenase activity" EXACT [EC:1.1.99.23]
xref: EC:1.1.99.23
xref: MetaCyc:1.1.99.23-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047060
name: (R)-pantolactone dehydrogenase (flavin) activity
namespace: molecular_function
def: "Catalysis of the reaction: acceptor + pantoyl lactone = reduced acceptor + 2-dehydropantoyl lactone." [EC:1.1.99.27, MetaCyc:1.1.99.27-RXN]
synonym: "(R)-pantolactone:acceptor oxidoreductase (flavin-containing)" EXACT [EC:1.1.99.27]
synonym: "(R)-pantoyllactone dehydrogenase (flavin) activity" EXACT [EC:1.1.99.27]
synonym: "2-dehydropantolactone reductase (flavin) activity" EXACT [EC:1.1.99.27]
synonym: "2-dehydropantoyl-lactone reductase (flavin) activity" EXACT [EC:1.1.99.27]
xref: EC:1.1.99.27
xref: MetaCyc:1.1.99.27-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047061
name: glucose-fructose oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: fructose + beta-D-glucose = D-sorbitol + glucono-delta-lactone." [EC:1.1.99.28, MetaCyc:1.1.99.28-RXN]
subset: gosubset_prok
synonym: "D-glucose:D-fructose oxidoreductase activity" EXACT [EC:1.1.99.28]
xref: EC:1.1.99.28
xref: MetaCyc:1.1.99.28-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047062
name: trans-acenaphthene-1,2-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + (+-)-trans-acenaphthene-1,2-diol = NADPH + H+ + acenaphthenequinone." [EC:1.10.1.1, MetaCyc:1.10.1.1-RXN]
synonym: "(+-)-trans-acenaphthene-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.10.1.1]
synonym: "trans-1,2-acenaphthenediol dehydrogenase activity" EXACT [EC:1.10.1.1]
xref: EC:1.10.1.1
xref: MetaCyc:1.10.1.1-RXN
is_a: GO:0016680 ! oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor

[Term]
id: GO:0047063
name: L-ascorbate-cytochrome-b5 reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: ferricytochrome B5 + ascorbate = ferrocytochrome B5 + monodehydroascorbate." [EC:1.10.2.1, MetaCyc:1.10.2.1-RXN]
synonym: "ascorbate-cytochrome b5 reductase activity" EXACT [EC:1.10.2.1]
synonym: "L-ascorbate:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.10.2.1]
xref: EC:1.10.2.1
xref: MetaCyc:1.10.2.1-RXN
is_a: GO:0016681 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor

[Term]
id: GO:0047064
name: sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 2 sulochrin = 2 H2O + 2 (+)-bisdechlorogeodin." [EC:1.21.3.4, MetaCyc:1.10.3.7-RXN]
synonym: "sulochrin oxidase activity" EXACT [EC:1.21.3.4]
synonym: "sulochrin:oxygen oxidoreductase (cyclizing, (+)-specific)" EXACT [EC:1.21.3.4]
xref: EC:1.21.3.4
xref: MetaCyc:1.10.3.7-RXN
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0047065
name: sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 2 sulochrin = 2 H2O + 2 (-)-bisdechlorogeodin." [EC:1.21.3.5, MetaCyc:1.10.3.8-RXN]
synonym: "sulochrin oxidase activity" BROAD [EC:1.21.3.5]
synonym: "sulochrin:oxygen oxidoreductase (cyclizing, (-)-specific)" EXACT [EC:1.21.3.5]
xref: EC:1.21.3.5
xref: MetaCyc:1.10.3.8-RXN
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0047066
name: phospholipid-hydroperoxide glutathione peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione." [EC:1.11.1.12, MetaCyc:1.11.1.12-RXN]
synonym: "glutathione:lipid-hydroperoxide oxidoreductase activity" EXACT [EC:1.11.1.12]
synonym: "hydroperoxide glutathione peroxidase activity" EXACT [EC:1.11.1.12]
synonym: "peroxidation-inhibiting protein activity" RELATED [EC:1.11.1.12]
synonym: "peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing)" EXACT [EC:1.11.1.12]
synonym: "PHGPX" RELATED [EC:1.11.1.12]
synonym: "phospholipid hydroperoxide glutathione peroxidase activity" EXACT [EC:1.11.1.12]
xref: EC:1.11.1.12
xref: MetaCyc:1.11.1.12-RXN
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0047067
name: hydrogen:quinone oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: menaquinone + H2 = reduced menaquinone." [EC:1.12.5.1, MetaCyc:1.12.99.3-RXN]
subset: gosubset_prok
synonym: "hydrogen-ubiquinone oxidoreductase activity" EXACT [EC:1.12.5.1]
synonym: "hydrogen:menaquinone oxidoreductase activity" EXACT [EC:1.12.5.1]
synonym: "membrane-bound hydrogenase activity" NARROW [EC:1.12.5.1]
synonym: "quinone-reactive Ni/Fe-hydrogenase activity" RELATED [EC:1.12.5.1]
xref: EC:1.12.5.1
xref: MetaCyc:1.12.5.1-RXN
is_a: GO:0046994 ! oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor

[Term]
id: GO:0047068
name: N5,N10-methenyltetrahydromethanopterin hydrogenase activity
namespace: molecular_function
alt_id: GO:0016947
def: "Catalysis of the reaction: H2 + N5,N10-methenyltetrahydromethanopterin = H+ + N5,N10-methylenetetrahydromethanopterin." [EC:1.12.98.2, MetaCyc:H2-METHYLENE-THMPT-DEHYDRO-RXN-RXN]
subset: gosubset_prok
synonym: "5,10-methenyltetrahydromethanopterin hydrogenase activity" EXACT [EC:1.12.98.2]
synonym: "H(2)-dependent methylene-H(4)MPT dehydrogenase activity" EXACT [EC:1.12.98.2]
synonym: "H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.12.98.2]
synonym: "H2-dependent methylene-H4MPT dehydrogenase activity" EXACT [EC:1.12.98.2]
synonym: "H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.12.98.2]
synonym: "hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2]
synonym: "hydrogen:N(5),N(10)-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2]
synonym: "hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase activity" EXACT [EC:1.12.98.2]
synonym: "N(5),N(10)-methenyltetrahydromethanopterin hydrogenase activity" EXACT [EC:1.12.98.2]
synonym: "N5,N10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT []
synonym: "nonmetal hydrogenase activity" RELATED [EC:1.12.98.2]
xref: EC:1.12.98.2
xref: MetaCyc:H2-METHYLENE-THMPT-DEHYDRO-RXN
is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors

[Term]
id: GO:0047069
name: 7,8-dihydroxykynurenate 8,8a-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 7,8-dihydroxykynurenate = 5-(3-carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate." [EC:1.13.11.10, MetaCyc:1.13.11.10-RXN]
synonym: "7,8-dihydroxykynurenate 8,8alpha-dioxygenase activity" EXACT [EC:1.13.11.10]
synonym: "7,8-dihydroxykynurenate oxygenase activity" EXACT [EC:1.13.11.10]
synonym: "7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.10]
xref: EC:1.13.11.10
xref: MetaCyc:1.13.11.10-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047070
name: 3-carboxyethylcatechol 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate." [EC:1.13.11.16, MetaCyc:1.13.11.16-RXN]
synonym: "2,3-dihydroxy-beta-phenylpropionate oxygenase activity" EXACT [EC:1.13.11.16]
synonym: "2,3-dihydroxy-beta-phenylpropionic dioxygenase activity" EXACT [EC:1.13.11.16]
synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.16]
synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.16]
xref: EC:1.13.11.16
xref: MetaCyc:1.13.11.16-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047071
name: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate." [EC:1.13.11.25, MetaCyc:1.13.11.25-RXN]
synonym: "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.25]
synonym: "3-alkylcatechol 2,3-dioxygenase activity" EXACT [EC:1.13.11.25]
synonym: "steroid 4,5-dioxygenase activity" BROAD [EC:1.13.11.25]
xref: EC:1.13.11.25
xref: MetaCyc:1.13.11.25-RXN
xref: UM-BBD_enzymeID:e0715
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047072
name: 2,3-dihydroxybenzoate 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 2,3-dihydroxybenzoate = 2-carboxy-cis,cis-muconate." [EC:1.13.11.28, MetaCyc:1.13.11.28-RXN]
synonym: "2,3-dihydroxybenzoate 2,3-oxygenase activity" EXACT [EC:1.13.11.28]
synonym: "2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.28]
xref: EC:1.13.11.28
xref: MetaCyc:1.13.11.28-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047073
name: 2,4'-dihydroxyacetophenone dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 2',4'-dihydroxyacetophenone = formate + p-hydroxybenzoate." [EC:1.13.11.41, MetaCyc:1.13.11.41-RXN]
subset: gosubset_prok
synonym: "(4-hydroxybenzoyl)methanol oxygenase activity" EXACT [EC:1.13.11.41]
synonym: "2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving)" EXACT [EC:1.13.11.41]
xref: EC:1.13.11.41
xref: MetaCyc:1.13.11.41-RXN
xref: UM-BBD_enzymeID:e0889
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047074
name: 4-hydroxycatechol 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + benzene-1,2,4-triol = maleylacetate." [EC:1.13.11.-, MetaCyc:R308-RXN]
xref: EC:1.13.11.-
xref: MetaCyc:RXN-10137
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047075
name: 2,5-dihydroxypyridine 5,6-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate." [EC:1.13.11.9, MetaCyc:1.13.11.9-RXN]
synonym: "2,5-dihydroxypyridine oxygenase activity" EXACT [EC:1.13.11.9]
synonym: "2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase activity" EXACT [EC:1.13.11.9]
synonym: "pyridine-2,5-diol dioxygenase activity" EXACT [EC:1.13.11.9]
xref: EC:1.13.11.9
xref: MetaCyc:1.13.11.9-RXN
xref: UM-BBD_enzymeID:e0911
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047077
name: Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + pyrophosphate + AMP + CO2 + oxidized Photinus luciferin." [EC:1.13.12.7, MetaCyc:1.13.12.7-RXN]
synonym: "firefly luciferase activity" EXACT [EC:1.13.12.7]
synonym: "firefly luciferin luciferase activity" EXACT [EC:1.13.12.7]
synonym: "luciferase (firefly luciferin)" EXACT [EC:1.13.12.7]
synonym: "luciferase activity" BROAD [EC:1.13.12.7]
synonym: "Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing)" EXACT [EC:1.13.12.7]
synonym: "Photinus pyralis luciferase activity" EXACT [EC:1.13.12.7]
synonym: "Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)" EXACT [EC:1.13.12.7]
synonym: "Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing)" EXACT [EC:1.13.12.7]
xref: EC:1.13.12.7
xref: MetaCyc:1.13.12.7-RXN
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0047078
name: 3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate." [EC:1.13.11.47, MetaCyc:1.13.11.47-RXN]
subset: gosubset_prok
synonym: "(1H)-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity" EXACT [EC:1.13.11.47]
synonym: "1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity" EXACT []
synonym: "3-hydroxy-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)" EXACT [EC:1.13.11.47]
synonym: "3-hydroxy-4(1H)-one, 2,4-dioxygenase activity" EXACT [EC:1.13.11.47]
synonym: "3-hydroxy-4-oxo-1,4-dihydroquinoline 2,4-dioxygenase activity" EXACT [EC:1.13.11.47]
synonym: "quinoline-3,4-diol 2,4-dioxygenase activity" EXACT [EC:1.13.11.47]
xref: EC:1.13.11.47
xref: MetaCyc:1.13.11.47-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047079
name: pyrimidine-deoxynucleoside 1'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 2-oxoglutarate + deoxyuridine = CO2 + succinate + dioxyribonolactone + uracil." [EC:1.14.11.10, MetaCyc:1.14.11.10-RXN]
synonym: "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating)" EXACT [EC:1.14.11.10]
synonym: "deoxyuridine-uridine 1'-dioxygenase activity" EXACT [EC:1.14.11.10]
synonym: "pyrimidine-deoxynucleoside,2-oxoglutarate 1'-dioxygenase activity" EXACT [EC:1.14.11.10]
xref: EC:1.14.11.10
xref: MetaCyc:1.14.11.10-RXN
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0047080
name: pyrimidine-deoxynucleoside 2'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 2-oxoglutarate + deoxyuridine = CO2 + succinate + uridine." [EC:1.14.11.3, MetaCyc:1.14.11.3-RXN]
synonym: "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2'-hydroxylating)" EXACT [EC:1.14.11.3]
synonym: "deoxyuridine 2'-dioxygenase activity" EXACT [EC:1.14.11.3]
synonym: "deoxyuridine 2'-hydroxylase activity" EXACT [EC:1.14.11.3]
synonym: "pyrimidine deoxyribonucleoside 2'-hydroxylase activity" EXACT [EC:1.14.11.3]
synonym: "pyrimidine-deoxynucleoside,2-oxoglutarate 2'-dioxygenase activity" EXACT [EC:1.14.11.3]
synonym: "thymidine 2'-dioxygenase activity" NARROW [EC:1.14.11.3]
synonym: "thymidine 2'-hydroxylase activity" NARROW [EC:1.14.11.3]
synonym: "thymidine 2-oxoglutarate dioxygenase activity" NARROW [EC:1.14.11.3]
synonym: "thymidine dioxygenase activity" NARROW [EC:1.14.11.3]
xref: EC:1.14.11.3
xref: MetaCyc:1.14.11.3-RXN
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0047081
name: 3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NAD(P)H + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NAD(P)+ + 2-(acetamidomethylene)succinate." [EC:1.14.12.4, MetaCyc:1.14.12.4-RXN]
synonym: "2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity" EXACT [EC:1.14.12.4]
synonym: "3-hydroxy-2-methylpyridine-5-carboxylate,NAD(P)H:oxygen oxidoreductase (decyclizing)" EXACT [EC:1.14.12.4]
synonym: "3-hydroxy-3-methylpyridinecarboxylate dioxygenase activity" EXACT [EC:1.14.12.4]
synonym: "methylhydroxypyridine carboxylate dioxygenase activity" EXACT [EC:1.14.12.4]
synonym: "methylhydroxypyridinecarboxylate oxidase activity" EXACT [EC:1.14.12.4]
xref: EC:1.14.12.4
xref: MetaCyc:1.14.12.4-RXN
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0047082
name: 3,9-dihydroxypterocarpan 6a-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + (6aR,11aR)-3,9-dihydroxypterocarpan = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H2O + NADP+. (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol." [EC:1.14.13.28, MetaCyc:1.14.13.28-RXN]
synonym: "(6aR,11aR)-3,9-dihydroxypterocarpan,NADPH:oxygen oxidoreductase (6a-hydroxylating)" EXACT [EC:1.14.13.28]
synonym: "3,9-dihydroxypterocarpan 6a-hydroxylase activity" EXACT []
synonym: "3,9-dihydroxypterocarpan 6alpha-monooxygenase (erroneous)" EXACT [EC:1.14.13.28]
xref: EC:1.14.13.28
xref: MetaCyc:RXN-4505
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047083
name: 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate." [EC:1.14.13.36, MetaCyc:1.14.13.36-RXN]
synonym: "5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase activity" EXACT []
synonym: "coumaroylquinate(coumaroylshikimate) 3'-monooxygenase activity" EXACT [EC:1.14.13.36]
synonym: "trans-5-O-(4-coumaroyl)-D-quinate,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.36]
xref: EC:1.14.13.36
xref: MetaCyc:1.14.13.36-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047084
name: methyltetrahydroprotoberberine 14-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine." [EC:1.14.13.37, MetaCyc:1.14.13.37-RXN]
synonym: "(S)-cis-N-methyltetrahydroberberine 14-monooxygenase activity" EXACT [EC:1.14.13.37]
synonym: "(S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase activity" EXACT [EC:1.14.13.37]
synonym: "(S)-N-methylcanadine,NADPH:oxygen oxidoreductase (14-hydroxylating)" EXACT [EC:1.14.13.37]
synonym: "methyltetrahydroprotoberberine 14-hydroxylase activity" EXACT []
xref: EC:1.14.13.37
xref: MetaCyc:1.14.13.37-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047085
name: hydroxyphenylacetonitrile 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + 4-hydroxyphenylacetonitrile = H2O + NADP+ + 4-hydroxymandelonitrile." [EC:1.14.13.42, MetaCyc:1.14.13.42-RXN]
synonym: "4-hydroxyphenylacetonitrile hydroxylase activity" EXACT [EC:1.14.13.42]
synonym: "4-hydroxyphenylacetonitrile monooxygenase activity" EXACT []
synonym: "4-hydroxyphenylacetonitrile,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.42]
xref: EC:1.14.13.42
xref: MetaCyc:1.14.13.42-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047086
name: ketosteroid monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate." [EC:1.14.13.54, MetaCyc:1.14.13.54-RXN]
synonym: "17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving)" EXACT [EC:1.14.13.54]
synonym: "androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)" EXACT [EC:1.14.13.54]
synonym: "ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing)" EXACT [EC:1.14.13.54]
synonym: "progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing)" EXACT [EC:1.14.13.54]
synonym: "steroid-ketone monooxygenase activity" EXACT [EC:1.14.13.54]
xref: EC:1.14.13.54
xref: MetaCyc:1.14.13.54-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047087
name: protopine 6-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + protopine = H2O + NADP+ + 6-hydroxyprotopine." [EC:1.14.13.55, MetaCyc:1.14.13.55-RXN]
synonym: "protopine 6-hydroxylase activity" EXACT []
synonym: "protopine,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.55]
xref: EC:1.14.13.55
xref: MetaCyc:1.14.13.55-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047088
name: dihydrosanguinarine 10-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + dihydrosanguinarine = H2O + NADP+ + 10-hydroxydihydrosanguinarine." [EC:1.14.13.56, MetaCyc:1.14.13.56-RXN]
synonym: "dihydrosanguinarine 10-hydroxylase activity" EXACT []
synonym: "dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)" EXACT [EC:1.14.13.56]
xref: EC:1.14.13.56
xref: MetaCyc:1.14.13.56-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047089
name: dihydrochelirubine 12-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + dihydrochelirubine = H2O + NADP+ + 10-hydroxydihydrochelirubine." [EC:1.14.13.57, MetaCyc:1.14.13.57-RXN]
synonym: "dihydrochelirubine 12-hydroxylase activity" EXACT []
synonym: "dihydrochelirubine,NADPH:oxygen oxidoreductase (12-hydroxylating)" EXACT [EC:1.14.13.57]
xref: EC:1.14.13.57
xref: MetaCyc:1.14.13.57-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047090
name: benzoyl-CoA 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoyl-CoA + O2 + NADPH = H2O + NADP+ + 3-hydroxybenzoyl-CoA." [EC:1.14.13.58, MetaCyc:1.14.13.58-RXN]
synonym: "benzoyl-CoA 3-hydroxylase activity" EXACT []
synonym: "benzoyl-CoA,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.58]
xref: EC:1.14.13.58
xref: MetaCyc:1.14.13.58-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047091
name: L-lysine 6-monooxygenase (NADPH) activity
namespace: molecular_function
alt_id: GO:0008739
def: "Catalysis of the reaction: O2 + NADPH + H+ + L-lysine = H2O + NADP+ + N6-hydroxy-L-lysine." [EC:1.14.13.59, MetaCyc:1.14.13.59-RXN]
comment: Note that EC:1.13.12.10 was merged into this term.
subset: gosubset_prok
synonym: "L-lysine 6-monooxygenase activity" EXACT []
synonym: "L-lysine,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.59]
synonym: "lysine N(6)-hydroxylase activity" EXACT [EC:1.14.13.59]
synonym: "lysine N6-hydroxylase activity" EXACT []
xref: EC:1.14.13.59
xref: MetaCyc:1.14.13.59-RXN
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047092
name: 27-hydroxycholesterol 7-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol." [EC:1.14.13.60, MetaCyc:1.14.13.60-RXN]
synonym: "27-hydroxycholesterol 7-alpha-hydroxylase activity" EXACT [EC:1.14.13.60]
synonym: "27-hydroxycholesterol 7a-hydroxylase activity" EXACT []
synonym: "27-hydroxycholesterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.60]
synonym: "27-hydroxycholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.60]
synonym: "27-hydroxycholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.60]
xref: EC:1.14.13.60
xref: MetaCyc:1.14.13.60-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047093
name: 4-hydroxyquinoline 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADH + quinolin-4-ol = H2O + NAD+ + quinolin-3,4-diol." [EC:1.14.13.62, MetaCyc:1.14.13.62-RXN]
synonym: "1-H-4-oxoquinoline 3-monooxygenase activity" EXACT [EC:1.14.13.62]
synonym: "quinolin-4(1H)-one 3-monooxygenase activity" EXACT [EC:1.14.13.62]
synonym: "quinolin-4(1H)-one,NADH:oxygen oxidoreductase (3-oxygenating)" EXACT [EC:1.14.13.62]
xref: EC:1.14.13.62
xref: MetaCyc:1.14.13.62-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047094
name: 3-hydroxyphenylacetate 6-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate." [EC:1.14.13.63, MetaCyc:1.14.13.63-RXN]
synonym: "3-hydroxyphenylacetate 6-monooxygenase activity" EXACT [EC:1.14.13.63]
synonym: "3-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.63]
xref: EC:1.14.13.63
xref: MetaCyc:1.14.13.63-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047095
name: 2-hydroxycyclohexanone 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + 2-hydroxycyclohexan-1-one = H2O + NADP+ + 6-hydroxyhexan-6-olide." [EC:1.14.13.66, MetaCyc:1.14.13.66-RXN]
synonym: "2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing)" EXACT [EC:1.14.13.66]
xref: EC:1.14.13.66
xref: MetaCyc:1.14.13.66-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047096
name: androst-4-ene-3,17-dione monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + donor-H2 + androst-4-ene-3,17-dione = H2O + acceptor + 3-oxo-13,17-secoandrost-4-eno-17,13-alpha-lactone." [EC:1.14.99.12, MetaCyc:1.14.99.12-RXN]
synonym: "4-androstene-3,17-dione monooxygenase activity" EXACT []
synonym: "androst-4-ene-3,17-dione 17-oxidoreductase activity" EXACT [EC:1.14.99.12]
synonym: "androst-4-ene-3,17-dione hydroxylase activity" EXACT [EC:1.14.99.12]
synonym: "androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)" EXACT [EC:1.14.99.12]
synonym: "androstene-3,17-dione hydroxylase activity" EXACT []
synonym: "androstenedione monooxygenase activity" EXACT [EC:1.14.99.12]
xref: EC:1.14.99.12
xref: MetaCyc:1.14.99.12-RXN
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0047097
name: phylloquinone monooxygenase (2,3-epoxidizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + donor-H2 + vitamin K1 = H2O + acceptor + 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone." [EC:1.14.99.20, MetaCyc:1.14.99.20-RXN]
synonym: "phylloquinone epoxidase activity" EXACT [EC:1.14.99.20]
synonym: "phylloquinone,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)" EXACT [EC:1.14.99.20]
synonym: "vitamin K 2,3-epoxidase activity" EXACT [EC:1.14.99.20]
synonym: "vitamin K epoxidase activity" EXACT [EC:1.14.99.20]
synonym: "vitamin K1 epoxidase activity" EXACT [EC:1.14.99.20]
xref: EC:1.14.99.20
xref: MetaCyc:1.14.99.20-RXN
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0047098
name: Latia-luciferin monooxygenase (demethylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 O2 + donor-H2 + Latia luciferin = light + H2O + acceptor + formate + CO2 + oxidized Latia luciferin." [EC:1.14.99.21, MetaCyc:1.14.99.21-RXN]
synonym: "Latia luciferin monooxygenase (demethylating)" EXACT [EC:1.14.99.21]
synonym: "Latia-luciferin,hydrogen-donor:oxygen oxidoreductase (demethylating)" EXACT [EC:1.14.99.21]
synonym: "luciferase (Latia luciferin)" EXACT [EC:1.14.99.21]
xref: EC:1.14.99.21
xref: MetaCyc:1.14.99.21-RXN
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0047099
name: CDP-4-dehydro-6-deoxyglucose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose." [EC:1.17.1.1, MetaCyc:1.17.1.1-RXN]
synonym: "CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase activity" EXACT [EC:1.17.1.1]
synonym: "CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system activity" EXACT [EC:1.17.1.1]
synonym: "CDP-4-keto-6-deoxyglucose reductase activity" EXACT [EC:1.17.1.1]
synonym: "CDP-4-keto-deoxy-glucose reductase activity" EXACT [EC:1.17.1.1]
synonym: "cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase activity" EXACT [EC:1.17.1.1]
synonym: "cytidine diphospho-4-keto-6-deoxy-D-glucose reductase activity" EXACT [EC:1.17.1.1]
synonym: "NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase activity" EXACT [EC:1.17.1.1]
xref: EC:1.17.1.1
xref: MetaCyc:1.17.1.1-RXN
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0047100
name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate." [EC:1.2.1.13, MetaCyc:1.2.1.13-RXN]
synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.13]
synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)" EXACT [EC:1.2.1.13]
synonym: "glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)" EXACT [EC:1.2.1.13]
synonym: "NADP-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.13]
synonym: "NADP-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.13]
synonym: "NADP-triose phosphate dehydrogenase activity" EXACT [EC:1.2.1.13]
synonym: "triosephosphate dehydrogenase (NADP(+)) activity" EXACT [EC:1.2.1.13]
synonym: "triosephosphate dehydrogenase (NADP)" EXACT [EC:1.2.1.13]
synonym: "triosephosphate dehydrogenase (NADP+) activity" EXACT [EC:1.2.1.13]
xref: EC:1.2.1.13
xref: MetaCyc:1.2.1.13-RXN
is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity

[Term]
id: GO:0047101
name: 2-oxoisovalerate dehydrogenase (acylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + CoA + 2-keto-isovalerate = NADH + CO2 + isobutyryl-CoA." [EC:1.2.1.25, MetaCyc:1.2.1.25-RXN]
synonym: "2-oxoisovalerate dehydrogenase activity" EXACT [EC:1.2.1.25]
synonym: "3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)" EXACT [EC:1.2.1.25]
xref: EC:1.2.1.25
xref: MetaCyc:1.2.1.25-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047102
name: aminomuconate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate." [EC:1.2.1.32, MetaCyc:1.2.1.32-RXN]
synonym: "2-aminomuconate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32]
synonym: "2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase activity" EXACT [EC:1.2.1.32]
synonym: "2-hydroxymuconate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32]
synonym: "2-hydroxymuconic acid semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32]
synonym: "2-hydroxymuconic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32]
synonym: "alpha-aminomuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32]
synonym: "alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.32]
xref: EC:1.2.1.32
xref: MetaCyc:1.2.1.32-RXN
xref: Reactome:82529 "aminomuconate-semialdehyde dehydrogenase activity"
xref: UM-BBD_enzymeID:e0904
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047103
name: 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate." [EC:1.2.1.40, MetaCyc:1.2.1.40-RXN]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-dehydrogenase activity" EXACT [EC:1.2.1.40]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al dehydrogenase activity" EXACT [EC:1.2.1.40]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase activity" EXACT [EC:1.2.1.40]
synonym: "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-dehydrogenase activity" EXACT [EC:1.2.1.40]
synonym: "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase activity" EXACT [EC:1.2.1.40]
synonym: "cholestanetriol-26-al 26-dehydrogenase activity" EXACT [EC:1.2.1.40]
synonym: "THAL-NAD oxidoreductase activity" EXACT [EC:1.2.1.40]
synonym: "trihydroxydeoxycoprostanal dehydrogenase activity" EXACT [EC:1.2.1.40]
xref: EC:1.2.1.40
xref: MetaCyc:1.2.1.40-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047104
name: hexadecanal dehydrogenase (acylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + CoA + palmitaldehyde = NADH + palmityl-CoA." [EC:1.2.1.42, MetaCyc:1.2.1.42-RXN]
synonym: "fatty acyl-CoA reductase activity" BROAD [EC:1.2.1.42]
synonym: "hexadecanal:NAD+ oxidoreductase (CoA-acylating)" EXACT [EC:1.2.1.42]
xref: EC:1.2.1.42
xref: MetaCyc:1.2.1.42-RXN
xref: UM-BBD_enzymeID:e0853
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047105
name: 4-trimethylammoniobutyraldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate." [EC:1.2.1.47, MetaCyc:1.2.1.47-RXN]
synonym: "4-N-trimethylaminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.47]
synonym: "4-trimethylaminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.47]
synonym: "4-trimethylammoniobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.47]
xref: EC:1.2.1.47
xref: MetaCyc:1.2.1.47-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047106
name: 4-hydroxyphenylacetaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate." [EC:1.2.1.53, MetaCyc:1.2.1.53-RXN]
synonym: "4-HPAL dehydrogenase activity" EXACT [EC:1.2.1.53]
synonym: "4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.53]
xref: EC:1.2.1.53
xref: MetaCyc:1.2.1.53-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047107
name: gamma-guanidinobutyraldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD+ + 4-guanidinobutanal = NADH + 4-guanidinobutanoate." [EC:1.2.1.54, MetaCyc:1.2.1.54-RXN]
synonym: "4-guanidinobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.54]
synonym: "4-guanidinobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.54]
synonym: "alpha-guanidinobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.54]
synonym: "GBAL dehydrogenase activity" EXACT [EC:1.2.1.54]
xref: EC:1.2.1.54
xref: MetaCyc:1.2.1.54-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047108
name: (R)-3-hydroxyacid-ester dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + ethyl (R)-3-hydroxyhexanoate = NADPH + ethyl-3-oxohexanoate." [EC:1.1.1.279, MetaCyc:1.2.1.55-RXN]
comment: Note that this term was EC:1.2.1.55.
synonym: "(R)-3-hydroxyacid ester dehydrogenase activity" EXACT []
synonym: "3-oxo ester (R)-reductase activity" EXACT [EC:1.1.1.279]
synonym: "ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.279]
xref: EC:1.1.1.279
xref: MetaCyc:1.2.1.55-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047109
name: (S)-3-hydroxyacid-ester dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + ethyl (S)-3-hydroxyhexanoate = NADPH + ethyl-3-oxohexanoate." [EC:1.1.1.280, MetaCyc:1.2.1.56-RXN]
comment: Note that this term was EC:1.2.1.56.
synonym: "(S)-3-hydroxyacid ester dehydrogenase activity" EXACT []
synonym: "3-oxo ester (S)-reductase activity" EXACT [EC:1.1.1.280]
synonym: "ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.280]
xref: EC:1.1.1.280
xref: MetaCyc:1.2.1.56-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047110
name: phenylglyoxylate dehydrogenase (acylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + NAD+ + phenylglyoxylate = NADH + CO2 + benzoyl-S-CoA." [EC:1.2.1.58, MetaCyc:1.2.1.58-RXN]
synonym: "phenylglyoxylate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.58]
xref: EC:1.2.1.58
xref: MetaCyc:1.2.1.58-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047111
name: formate dehydrogenase (cytochrome-c-553) activity
namespace: molecular_function
def: "Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2." [EC:1.2.2.3, MetaCyc:1.2.2.3-RXN]
synonym: "formate dehydrogenase (cytochrome c-553)" EXACT [EC:1.2.2.3]
synonym: "formate:ferricytochrome-c-553 oxidoreductase activity" EXACT [EC:1.2.2.3]
xref: EC:1.2.2.3
xref: MetaCyc:1.2.2.3-RXN
is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor

[Term]
id: GO:0047112
name: pyruvate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + phosphate + pyruvate = H2O2 + CO2 + acetylphosphate." [EC:1.2.3.3, MetaCyc:1.2.3.3-RXN]
subset: gosubset_prok
synonym: "phosphate-dependent pyruvate oxidase activity" EXACT [EC:1.2.3.3]
synonym: "pyruvate:oxygen 2-oxidoreductase (phosphorylating)" EXACT [EC:1.2.3.3]
synonym: "pyruvic oxidase activity" EXACT [EC:1.2.3.3]
xref: EC:1.2.3.3
xref: MetaCyc:1.2.3.3-RXN
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0047113
name: aldehyde dehydrogenase (pyrroloquinoline-quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + acceptor + an aldehyde = donor-H2 + an acid." [EC:1.2.99.3, MetaCyc:1.2.99.3-RXN]
subset: gosubset_prok
synonym: "aldehyde dehydrogenase (acceptor) activity" EXACT [EC:1.2.99.3]
synonym: "aldehyde:(pyrroloquinoline-quinone) oxidoreductase activity" EXACT [EC:1.2.99.3]
xref: EC:1.2.99.3
xref: MetaCyc:1.2.99.3-RXN
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0047114
name: kynurenate-7,8-dihydrodiol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 7,8-dihydro-7,8-dihydroxykynurenate = NADH + 7,8-dihydroxykynurenate." [EC:1.3.1.18, MetaCyc:1.3.1.18-RXN]
synonym: "7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase activity" EXACT [EC:1.3.1.18]
synonym: "7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.18]
synonym: "7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase activity" EXACT [EC:1.3.1.18]
xref: EC:1.3.1.18
xref: MetaCyc:1.3.1.18-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047115
name: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol." [EC:1.3.1.20, MetaCyc:1.3.1.20-RXN]
subset: gosubset_prok
synonym: "dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.20]
synonym: "trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.20]
xref: EC:1.3.1.20
xref: MetaCyc:1.3.1.20-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047116
name: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol." [EC:1.3.1.25, MetaCyc:1.3.1.25-RXN]
synonym: "(1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.25]
synonym: "2-hydro-1,2-dihydroxybenzoate dehydrogenase activity" EXACT [EC:1.3.1.25]
synonym: "3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase activity" EXACT [EC:1.3.1.25]
synonym: "3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase activity" EXACT [EC:1.3.1.25]
synonym: "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD(+) oxidoreductase activity" EXACT [EC:1.3.1.25]
synonym: "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.25]
synonym: "DHB dehydrogenase activity" EXACT [EC:1.3.1.25]
synonym: "DHBDH activity" EXACT [EC:1.3.1.25]
synonym: "dihydrodihydroxybenzoate dehydrogenase activity" EXACT [EC:1.3.1.25]
xref: EC:1.3.1.25
xref: MetaCyc:1.3.1.25-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047117
name: enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.39, MetaCyc:1.3.1.39-RXN]
synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (A-specific)" EXACT [EC:1.3.1.39]
synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, A-specific) activity" EXACT []
synonym: "enoyl-ACP reductase (NADPH, A-specific) activity" EXACT []
synonym: "enoyl-ACp reductase activity" EXACT [EC:1.3.1.39]
synonym: "enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.39]
synonym: "enoyl-acyl-carrier-protein reductase (NADPH, A-specific)" EXACT [EC:1.3.1.39]
xref: EC:1.3.1.39
xref: MetaCyc:1.3.1.39-RXN
is_a: GO:0016631 ! enoyl-[acyl-carrier-protein] reductase activity

[Term]
id: GO:0047118
name: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 2,6-dioxo-6-phenylhexanoate = NADPH + 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate." [EC:1.3.1.40, MetaCyc:1.3.1.40-RXN]
synonym: "2,6-dioxo-6-phenylhexanoate:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.40]
synonym: "2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.40]
xref: EC:1.3.1.40
xref: MetaCyc:1.3.1.40-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047119
name: 2-methyl-branched-chain-enoyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + 2-methylbutyryl-CoA = NADH + 2-methylcrotonoyl-CoA." [EC:1.3.1.52, MetaCyc:1.3.1.52-RXN]
synonym: "2-methyl-branched-chain-acyl-CoA:NAD+ 2-oxidoreductase activity" EXACT [EC:1.3.1.52]
xref: EC:1.3.1.52
xref: MetaCyc:1.3.1.52-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047120
name: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity
namespace: molecular_function
alt_id: GO:0018514
def: "Catalysis of the reaction: NAD+ + (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate = NADH + CO2 + protocatechuate." [EC:1.3.1.53, MetaCyc:1.3.1.53-RXN]
synonym: "(1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity" EXACT [EC:1.3.1.53]
synonym: "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.53]
synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.53]
synonym: "dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity" EXACT [EC:1.3.1.53]
synonym: "terephthalate 1,2-cis-dihydrodiol dehydrogenase activity" EXACT []
xref: EC:1.3.1.53
xref: MetaCyc:1.3.1.53-RXN
xref: UM-BBD_enzymeID:e0108
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047121
name: isoquinoline 1-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + acceptor + isoquinoline = donor-H2 + isoquinolin-12H-one." [EC:1.3.99.16, MetaCyc:1.3.99.16-RXN]
subset: gosubset_prok
synonym: "isoquinoline:acceptor 1-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.16]
xref: EC:1.3.99.16
xref: MetaCyc:1.3.99.16-RXN
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047122
name: quinaldate 4-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + acceptor + quinaldate = donor-H2 + kynurenate." [EC:1.3.99.18, MetaCyc:1.3.99.18-RXN]
synonym: "quinaldic acid 4-oxidoreductase activity" EXACT [EC:1.3.99.18]
synonym: "quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.18]
xref: EC:1.3.99.18
xref: MetaCyc:1.3.99.18-RXN
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047123
name: quinoline-4-carboxylate 2-oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + acceptor + quinoline-4-carboxylate = quinolin-2-ol + donor-H2." [EC:1.3.99.19, MetaCyc:1.3.99.19-RXN]
synonym: "quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.19]
synonym: "quinoline-4-carboxylic acid 2-oxidoreductase activity" EXACT [EC:1.3.99.19]
xref: EC:1.3.99.19
xref: MetaCyc:1.3.99.19-RXN
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047124
name: L-erythro-3,5-diaminohexanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + H2O + (3S,5S)-3,5-diaminohexanoate = NADH + NH3 + (S)-5-amino-3-oxohexanoate." [EC:1.4.1.11, MetaCyc:1.4.1.11-RXN]
synonym: "L-3,5-diaminohexanoate dehydrogenase activity" EXACT [EC:1.4.1.11]
synonym: "L-erythro-3,5-diaminohexanoate:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.11]
xref: EC:1.4.1.11
xref: MetaCyc:1.4.1.11-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047125
name: delta1-piperideine-2-carboxylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta(1)-piperideine-2-carboxylate." [EC:1.5.1.21, MetaCyc:1.5.1.21-RXN]
synonym: "1,2-didehydropipecolate reductase activity" EXACT [EC:1.5.1.21]
synonym: "1,2-didehydropipecolic reductase activity" EXACT [EC:1.5.1.21]
synonym: "D1-piperideine-2-carboxylate reductase activity" EXACT []
synonym: "delta 1-piperideine-2-carboxylate reductase activity" EXACT []
synonym: "L-pipecolate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.5.1.21]
synonym: "P2C reductase activity" EXACT [EC:1.5.1.21]
xref: EC:1.5.1.21
xref: MetaCyc:RXN-8166
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047126
name: N5-(carboxyethyl)ornithine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NADP+ + N5-(L-1-carboxyethyl)-L-ornithine = NADPH + pyruvate + L-ornithine." [EC:1.5.1.24, MetaCyc:1.5.1.24-RXN]
subset: gosubset_prok
synonym: "5-N-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)" EXACT [EC:1.5.1.24]
synonym: "N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)" EXACT [EC:1.5.1.24]
xref: EC:1.5.1.24
xref: MetaCyc:1.5.1.24-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047127
name: thiomorpholine-carboxylate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate." [EC:1.5.1.25, MetaCyc:1.5.1.25-RXN]
synonym: "ketimine reductase activity" EXACT [EC:1.5.1.25]
synonym: "ketimine-reducing enzyme" RELATED [EC:1.5.1.25]
synonym: "thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase activity" EXACT [EC:1.5.1.25]
xref: EC:1.5.1.25
xref: MetaCyc:1.5.1.25-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047128
name: 1,2-dehydroreticulinium reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + 1,2-dehydroreticulinium = NADP+ + R-reticuline." [EC:1.5.1.27, MetaCyc:1.5.1.27-RXN]
synonym: "(R)-reticuline:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.27]
synonym: "1,2-dehydroreticulinium ion reductase activity" EXACT [EC:1.5.1.27]
xref: EC:1.5.1.27
xref: MetaCyc:1.5.1.27-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047129
name: opine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD+ + (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate = NADH + pyruvate + L-2-aminopentanoic acid." [EC:1.5.1.28, MetaCyc:1.5.1.28-RXN]
subset: gosubset_prok
synonym: "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD, L-aminopentanoate-forming)" EXACT [EC:1.5.1.28]
synonym: "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate:NAD+ oxidoreductase (L-aminopentanoate-forming)" EXACT [EC:1.5.1.28]
xref: EC:1.5.1.28
xref: MetaCyc:1.5.1.28-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047130
name: saccharopine dehydrogenase (NADP+, L-lysine-forming) activity
namespace: molecular_function
alt_id: GO:0010010
def: "Catalysis of the reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-lysine + 2-oxoglutarate + NADPH + H+." [EC:1.5.1.8, MetaCyc:1.5.1.8-RXN]
subset: gosubset_prok
synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.8]
synonym: "L-lysine-alpha-ketoglutarate reductase activity" EXACT [EC:1.5.1.8]
synonym: "lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming)" EXACT [EC:1.5.1.8]
synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.8]
synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase activity" EXACT [EC:1.5.1.8]
xref: EC:1.5.1.8
xref: MetaCyc:1.5.1.8-RXN
is_a: GO:0004753 ! saccharopine dehydrogenase activity

[Term]
id: GO:0047131
name: saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+." [EC:1.5.1.9, MetaCyc:1.5.1.9-RXN]
synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.9]
synonym: "aminoadipic semialdehyde synthase activity" EXACT [EC:1.5.1.9]
synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming)" EXACT [EC:1.5.1.9]
synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.9]
synonym: "NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming)" EXACT [EC:1.5.1.9]
synonym: "saccharopin dehydrogenase activity" EXACT [EC:1.5.1.9]
xref: EC:1.5.1.9
xref: MetaCyc:1.5.1.9-RXN
is_a: GO:0004753 ! saccharopine dehydrogenase activity

[Term]
id: GO:0047132
name: dihydrobenzophenanthridine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine." [EC:1.5.3.12, MetaCyc:1.5.3.12-RXN]
synonym: "dihydrobenzophenanthridine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.12]
xref: EC:1.5.3.12
xref: MetaCyc:1.5.3.12-RXN
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0047133
name: dimethylamine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine." [EC:1.5.8.1, MetaCyc:1.5.8.1-RXN]
subset: gosubset_prok
synonym: "dimethylamine:electron-transferring flavoprotein oxidoreductase activity" EXACT [EC:1.5.8.1]
synonym: "DMADh activity" EXACT [EC:1.5.8.1]
xref: EC:1.5.8.1
xref: MetaCyc:1.5.8.1-RXN
xref: UM-BBD_enzymeID:e0855
is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, with a flavin as acceptor

[Term]
id: GO:0047134
name: protein-disulfide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+." [EC:1.8.1.8, MetaCyc:1.6.4.4-RXN]
subset: gosubset_prok
synonym: "disulfide reductase activity" EXACT [EC:1.8.1.8]
synonym: "insulin-glutathione transhydrogenase activity" EXACT [EC:1.8.1.8]
synonym: "NAD(P)H2:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.1.8]
synonym: "NAD(P)H:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.1.8]
synonym: "protein disulfide reductase activity" EXACT [EC:1.8.1.8]
synonym: "protein disulphide reductase activity" EXACT [EC:1.8.1.8]
synonym: "protein-disulfide reductase (NAD(P)H) activity" EXACT []
synonym: "protein-disulphide reductase activity" EXACT []
synonym: "protein-dithiol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.8]
xref: EC:1.8.1.8
xref: MetaCyc:1.6.4.4-RXN
is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047135
name: bis-gamma-glutamylcystine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 gamma-glutamylcysteine + NADP+ = bis-gamma-glutamylcystine + NADPH + H+." [EC:1.8.1.13, MetaCyc:1.6.4.9-RXN]
synonym: "bis-g-glutamylcystine reductase (NADPH) activity" EXACT []
synonym: "Bis-gamma-glutamylcystine reductase (NADPH)" EXACT [EC:1.8.1.13]
synonym: "bis-gamma-glutamylcystine reductase (NADPH) activity" EXACT [EC:1.8.1.13]
synonym: "gamma-glutamylcysteine:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.13]
synonym: "NADPH2:bis-gamma-glutamylcysteine oxidoreductase activity" EXACT [EC:1.8.1.13]
synonym: "NADPH:bis-gamma-glutamylcysteine oxidoreductase activity" EXACT [EC:1.8.1.13]
xref: EC:1.8.1.13
xref: MetaCyc:1.6.4.9-RXN
is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047136
name: 4-(dimethylamino)phenylazoxybenzene reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-dimethylaminophenylazobenzene + NADP+ = 4-(dimethylamino)phenylazoxybenzene + NADPH + H+." [EC:1.7.1.11, MetaCyc:1.6.6.12-RXN]
synonym: "4-(dimethylamino)phenylazobenzene:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.11]
synonym: "dimethylaminoazobenzene N-oxide reductase activity" EXACT [EC:1.7.1.11]
synonym: "N,N-dimethyl-p-aminoazobenzene oxide reductase activity" EXACT [EC:1.7.1.11]
synonym: "NADPH-dependent DMAB N-oxide reductase activity" EXACT [EC:1.7.1.11]
synonym: "NADPH2:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity" EXACT [EC:1.7.1.11]
synonym: "NADPH:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity" EXACT [EC:1.7.1.11]
xref: EC:1.7.1.11
xref: MetaCyc:1.6.6.12-RXN
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0047137
name: N-hydroxy-2-acetamidofluorene reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+." [EC:1.7.1.12, MetaCyc:1.7.1.12-RXN]
synonym: "2-acetamidofluorene:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.12]
synonym: "N-hydroxy-2-acetylaminofluorene reductase activity" EXACT [EC:1.7.1.12]
synonym: "NAD(P)H2:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity" EXACT [EC:1.7.1.12]
synonym: "NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity" EXACT [EC:1.7.1.12]
xref: EC:1.7.1.12
xref: MetaCyc:1.7.1.12-RXN
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0047138
name: aquacobalamin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 cob(II)alamin + NAD+ = 2 aquacob(III)alamin + NADH + H+." [EC:1.16.1.3, MetaCyc:1.6.99.12-RXN]
subset: gosubset_prok
synonym: "aquocobalamin reductase activity" EXACT [EC:1.16.1.3]
synonym: "B(12a) reductase activity" EXACT [EC:1.16.1.3]
synonym: "B12a reductase activity" EXACT [EC:1.16.1.3]
synonym: "cob(II)alamin:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.3]
synonym: "NADH-linked aquacobalamin reductase activity" EXACT [EC:1.16.1.3]
synonym: "NADH2:cob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.3]
synonym: "NADH:cob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.3]
synonym: "vitamin B(12a) reductase activity" EXACT [EC:1.16.1.3]
synonym: "vitamin B12a reductase activity" EXACT [EC:1.16.1.3]
xref: EC:1.16.1.3
xref: MetaCyc:AQUACOBALAMIN-REDUCTASE-RXN
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0047139
name: glutathione-homocystine transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine." [EC:1.8.4.1, MetaCyc:1.8.4.1-RXN]
synonym: "glutathione:homocystine oxidoreductase activity" EXACT [EC:1.8.4.1]
xref: EC:1.8.4.1
xref: MetaCyc:1.8.4.1-RXN
is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0047140
name: glutathione-CoA-glutathione transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione." [EC:1.8.4.3, MetaCyc:1.8.4.3-RXN]
synonym: "CoA:glutathione-disulfide oxidoreductase activity" EXACT [EC:1.8.4.3]
synonym: "coenzyme A:glutathione-disulfide oxidoreductase activity" EXACT [EC:1.8.4.3]
synonym: "coenzyme A:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.4.3]
synonym: "glutathione coenzyme A-glutathione transhydrogenase activity" EXACT [EC:1.8.4.3]
synonym: "glutathione-coenzyme A glutathione disulfide transhydrogenase activity" EXACT [EC:1.8.4.3]
synonym: "glutathione:coenzyme A-glutathione transhydrogenase activity" EXACT [EC:1.8.4.3]
xref: EC:1.8.4.3
xref: MetaCyc:1.8.4.3-RXN
is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0047141
name: glutathione-cystine transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine." [EC:1.8.4.4, MetaCyc:1.8.4.4-RXN]
synonym: "glutathione:cystine oxidoreductase" EXACT [EC:1.8.4.4]
synonym: "GSH-cystine transhydrogenase" EXACT [EC:1.8.4.4]
synonym: "NADPH-dependent GSH-cystine transhydrogenase" EXACT [EC:1.8.4.4]
xref: EC:1.8.4.4
xref: MetaCyc:1.8.4.4-RXN
is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0047142
name: enzyme-thiol transhydrogenase (glutathione-disulfide) activity
namespace: molecular_function
def: "Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase." [EC:1.8.4.7, MetaCyc:1.8.4.7-RXN]
synonym: "[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase activity" EXACT [EC:1.8.4.7]
synonym: "enzyme-thiol transhydrogenase (glutathione-disulphide) activity" EXACT []
synonym: "enzyme-thiol transhydrogenase (oxidized-glutathione) activity" EXACT []
synonym: "glutathione-dependent thiol:disulfide oxidoreductase activity" EXACT [EC:1.8.4.7]
synonym: "thiol:disulfide oxidoreductase activity" EXACT [EC:1.8.4.7]
synonym: "thiol:disulphide oxidoreductase activity" EXACT [EC:1.8.4.7]
synonym: "xanthine-dehydrogenase:glutathione-disulfide S-oxidoreductase activity" EXACT [EC:1.8.4.7]
synonym: "xanthine-dehydrogenase:oxidized-glutathione S-oxidoreductase activity" EXACT [EC:1.8.4.7]
xref: EC:1.8.4.7
xref: MetaCyc:1.8.4.7-RXN
is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0047143
name: chlorate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlorate + donor-H2 = chlorite + H2O + acceptor." [EC:1.97.1.1, MetaCyc:1.97.1.1-RXN]
subset: gosubset_prok
synonym: "chlorate reductase C" RELATED [EC:1.97.1.1]
synonym: "chlorite:acceptor oxidoreductase activity" EXACT [EC:1.97.1.1]
xref: EC:1.97.1.1
xref: MetaCyc:1.97.1.1-RXN
xref: UM-BBD_enzymeID:e0609
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0047144
name: 2-acylglycerol-3-phosphate O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA." [EC:2.3.1.52, MetaCyc:2-ACYL2.3.1.15-RXN]
synonym: "2-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.52]
synonym: "acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase activity" EXACT [EC:2.3.1.52]
xref: EC:2.3.1.52
xref: MetaCyc:2-ACYL2.3.1.15-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047145
name: demethylsterigmatocystin 6-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-demethylsterigmatocystin + S-adenosyl-L-methionine = sterigmatocystin + S-adenosyl-homocysteine." [EC:2.1.1.109, MetaCyc:2.1.1.109-RXN]
synonym: "demethylsterigmatocystin methyltransferase activity" EXACT [EC:2.1.1.109]
synonym: "O-methyltransferase I" RELATED [EC:2.1.1.109]
synonym: "S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase activity" EXACT [EC:2.1.1.109]
xref: EC:2.1.1.109
xref: MetaCyc:2.1.1.109-RXN
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0047146
name: sterigmatocystin 7-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine." [EC:2.1.1.110, MetaCyc:2.1.1.110-RXN]
synonym: "O-methyltransferase II activity" RELATED [EC:2.1.1.110]
synonym: "S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase activity" EXACT [EC:2.1.1.110]
synonym: "S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase activity" EXACT [EC:2.1.1.110]
synonym: "sterigmatocystin 8-O-methyltransferase activity" EXACT [EC:2.1.1.110]
synonym: "sterigmatocystin methyltransferase activity" EXACT [EC:2.1.1.110]
xref: EC:2.1.1.110
xref: MetaCyc:2.1.1.110-RXN
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0047147
name: trimethylsulfonium-tetrahydrofolate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: THF + trimethyl sulfonium = 5-methyl-THF + dimethyl sulfide." [EC:2.1.1.19, MetaCyc:2.1.1.19-RXN]
synonym: "trimethylsulfonium-tetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.19]
synonym: "trimethylsulfonium:tetrahydrofolate N-methyltransferase activity" EXACT [EC:2.1.1.19]
synonym: "trimethylsulphonium-tetrahydrofolate N-methyltransferase activity" EXACT []
xref: EC:2.1.1.19
xref: MetaCyc:2.1.1.19-RXN
is_a: GO:0008170 ! N-methyltransferase activity

[Term]
id: GO:0047148
name: methylamine-glutamate N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + methylamine = N-methyl-L-glutamate + NH3." [EC:2.1.1.21, MetaCyc:2.1.1.21-RXN]
synonym: "methylamine-glutamate methyltransferase activity" EXACT [EC:2.1.1.21]
synonym: "methylamine:L-glutamate N-methyltransferase activity" EXACT [EC:2.1.1.21]
synonym: "N-methylglutamate synthase activity" EXACT [EC:2.1.1.21]
xref: EC:2.1.1.21
xref: MetaCyc:2.1.1.21-RXN
is_a: GO:0008170 ! N-methyltransferase activity

[Term]
id: GO:0047149
name: thetin-homocysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: homocysteine + dimethylsulfonioacetate = L-methionine + S-methylthioglycolate." [EC:2.1.1.3, MetaCyc:2.1.1.3-RXN]
synonym: "dimethylsulfonioacetate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.3]
synonym: "dimethylthetin-homocysteine methyltransferase activity" EXACT [EC:2.1.1.3]
synonym: "thetin-homocysteine methylpherase activity" EXACT [EC:2.1.1.3]
xref: EC:2.1.1.3
xref: MetaCyc:2.1.1.3-RXN
is_a: GO:0008172 ! S-methyltransferase activity

[Term]
id: GO:0047150
name: betaine-homocysteine S-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: homocysteine + betaine = L-methionine + dimethylglycine." [EC:2.1.1.5, MetaCyc:2.1.1.5-RXN]
synonym: "betaine-homocysteine methyltransferase activity" EXACT [EC:2.1.1.5]
synonym: "betaine-homocysteine transmethylase activity" EXACT [EC:2.1.1.5]
synonym: "trimethylammonioacetate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.5]
xref: EC:2.1.1.5
xref: MetaCyc:2.1.1.5-RXN
is_a: GO:0008172 ! S-methyltransferase activity

[Term]
id: GO:0047151
name: methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: FADH + H+ + tRNA U(psi)C = FAD+ + tRNA T(psi)C + THF." [EC:2.1.1.74, MetaCyc:2.1.1.74-RXN]
synonym: "5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyltransferase activity" EXACT [EC:2.1.1.74]
synonym: "5,10-methylenetetrahydrofolate:tRNA-UPsiC (uracil-5-)-methyl-transferase activity" EXACT [EC:2.1.1.74]
synonym: "folate-dependent ribothymidyl synthase activity" EXACT [EC:2.1.1.74]
synonym: "methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase activity" EXACT [EC:2.1.1.74]
synonym: "methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH-oxidizing) activity" EXACT []
xref: EC:2.1.1.74
xref: MetaCyc:2.1.1.74-RXN
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0047152
name: methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxybenzimidazolylcobamide + methanol = H2O + Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide." [EC:2.1.1.90, MetaCyc:2.1.1.90-RXN]
comment: This function is the first step in the pathway of methanogenesis from methanol.
subset: gosubset_prok
synonym: "methanol cobalamin methyltransferase activity" EXACT [EC:2.1.1.90]
synonym: "methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase activity" EXACT [EC:2.1.1.90]
synonym: "methanol:5-hydroxybenzimidazolylcobamide methyltransferase activity" EXACT [EC:2.1.1.90]
synonym: "methanol:corrinoid methyltransferase activity" EXACT []
synonym: "methyltransferase 1" BROAD []
synonym: "MT 1" RELATED [EC:2.1.1.90]
synonym: "MT1" RELATED []
synonym: "MtaB" RELATED []
xref: EC:2.1.1.90
xref: MetaCyc:2.1.1.90-RXN
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0047153
name: deoxycytidylate 5-hydroxymethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + H2O + deoxycytidylate = tetrahydrofolate + 5-hydroxymethyldeoxycytidylate." [EC:2.1.2.8, MetaCyc:2.1.2.8-RXN]
synonym: "5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase activity" EXACT [EC:2.1.2.8]
synonym: "d-cytidine 5'-monophosphate hydroxymethylase activity" EXACT [EC:2.1.2.8]
synonym: "dCMP hydroxymethylase activity" EXACT [EC:2.1.2.8]
synonym: "deoxyCMP hydroxymethylase activity" EXACT [EC:2.1.2.8]
synonym: "deoxycytidylate hydroxymethylase activity" EXACT [EC:2.1.2.8]
synonym: "deoxycytidylate hydroxymethyltransferase activity" EXACT []
synonym: "deoxycytidylic hydroxymethylase activity" EXACT [EC:2.1.2.8]
xref: EC:2.1.2.8
xref: MetaCyc:2.1.2.8-RXN
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0047154
name: methylmalonyl-CoA carboxytransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA." [EC:2.1.3.1, MetaCyc:2.1.3.1-RXN]
subset: gosubset_prok
synonym: "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate" RELATED [EC:2.1.3.1]
synonym: "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase activity" EXACT [EC:2.1.3.1]
synonym: "(S)-methylmalonyl-CoA:pyruvate carboxyltransferase activity" EXACT [EC:2.1.3.1]
synonym: "(S)-methylmalonyl-CoA:pyruvate carboxytransferase activity" EXACT [EC:2.1.3.1]
synonym: "methylmalonyl coenzyme A carboxyltransferase activity" EXACT [EC:2.1.3.1]
synonym: "methylmalonyl-CoA carboxyltransferase activity" EXACT []
synonym: "methylmalonyl-CoA transcarboxylase activity" EXACT [EC:2.1.3.1]
synonym: "oxalacetic transcarboxylase activity" EXACT [EC:2.1.3.1]
synonym: "transcarboxylase activity" RELATED [EC:2.1.3.1]
xref: EC:2.1.3.1
xref: MetaCyc:2.1.3.1-RXN
xref: UM-BBD_enzymeID:e0576
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0047155
name: 3-hydroxymethylcephem carbamoyltransferase activity
namespace: molecular_function
alt_id: GO:0045447
def: "Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem." [EC:2.1.3.7, MetaCyc:2.1.3.7-RXN]
synonym: "3'-hydroxymethylcephem-O-carbamoyltransferase activity" EXACT []
synonym: "carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase activity" EXACT [EC:2.1.3.7]
xref: EC:2.1.3.7
xref: MetaCyc:2.1.3.7-RXN
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0047156
name: acetoin-ribose-5-phosphate transaldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ribose-5-phosphate + 3-hydroxybutan-2-one = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde." [EC:2.2.1.4, MetaCyc:2.2.1.4-RXN]
synonym: "1-deoxy-D-altro-heptulose-7-phosphate synthase activity" EXACT [EC:2.2.1.4]
synonym: "1-deoxy-D-altro-heptulose-7-phosphate synthetase activity" EXACT [EC:2.2.1.4]
synonym: "3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase activity" EXACT [EC:2.2.1.4]
synonym: "3-hydroxybutan-3-one:D-ribose-5-phosphate aldehydetransferase activity" EXACT [EC:2.2.1.4]
xref: EC:2.2.1.4
xref: MetaCyc:2.2.1.4-RXN
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0047157
name: myelin-proteolipid O-palmitoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA." [EC:2.3.1.100, MetaCyc:2.3.1.100-RXN]
synonym: "[myelin-proteolipid] O-palmitoyltransferase activity" EXACT [EC:2.3.1.100]
synonym: "acyl-protein synthase activity" BROAD [EC:2.3.1.100]
synonym: "myelin PLP acyltransferase activity" EXACT [EC:2.3.1.100]
synonym: "palmitoyl-CoA:[myelin-proteolipid] O-palmitoyltransferase activity" EXACT [EC:2.3.1.100]
xref: EC:2.3.1.100
xref: MetaCyc:2.3.1.100-RXN
is_a: GO:0016416 ! O-palmitoyltransferase activity

[Term]
id: GO:0047158
name: sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 1-O-sinapoyl-beta-D-glucoside = 1,2-bis-O-sinapoyl beta-D-glucoside + beta-D-glucose." [EC:2.3.1.103, MetaCyc:2.3.1.103-RXN]
synonym: "1-(hydroxycinnamoyl)-glucose:1-(hydroxycinnamoyl)-glucose hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.103]
synonym: "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucoside:1-O-(4-hydroxy-3,5-dimethoxycinnamoyl-beta-D-glucoside 1-O-sinapoyltransferase activity" EXACT [EC:2.3.1.103]
synonym: "hydroxycinnamoylglucose-hydroxycinnamoylglucose hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.103]
xref: EC:2.3.1.103
xref: MetaCyc:2.3.1.103-RXN
is_a: GO:0016753 ! O-sinapoyltransferase activity

[Term]
id: GO:0047159
name: 1-alkenylglycerophosphocholine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA." [EC:2.3.1.104, MetaCyc:2.3.1.104-RXN]
synonym: "acyl-CoA:1-alkenylglycerophosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.104]
xref: EC:2.3.1.104
xref: MetaCyc:2.3.1.104-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047160
name: alkylglycerophosphate 2-O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA." [EC:2.3.1.105, MetaCyc:2.3.1.105-RXN]
synonym: "acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase activity" EXACT [EC:2.3.1.105]
synonym: "alkyllyso-GP:acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.105]
xref: EC:2.3.1.105
xref: MetaCyc:2.3.1.105-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047161
name: tartronate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxymalonate + sinapoyl-CoA = sinapoyltartronate + CoA." [EC:2.3.1.106, MetaCyc:2.3.1.106-RXN]
synonym: "hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.106]
synonym: "sinapoyl-CoA:2-hydroxymalonate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.106]
synonym: "tartronate sinapoyltransferase activity" EXACT [EC:2.3.1.106]
xref: EC:2.3.1.106
xref: MetaCyc:2.3.1.106-RXN
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047162
name: 17-O-deacetylvindoline O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 17-O-deacetylvindoline + acetyl-CoA = vindoline + CoA." [EC:2.3.1.107, MetaCyc:2.3.1.107-RXN]
synonym: "17-O-deacetylvindoline-17-O-acetyltransferase activity" EXACT [EC:2.3.1.107]
synonym: "acetyl-CoA-17-O-deacetylvindoline 17-O-acetyltransferase activity" EXACT [EC:2.3.1.107]
synonym: "acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase activity" EXACT [EC:2.3.1.107]
synonym: "acetyl-CoA:deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107]
synonym: "acetylcoenzyme A-deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107]
synonym: "acetylcoenzyme A:deacetylvindoline 4-O-acetyltransferase activity" EXACT [EC:2.3.1.107]
synonym: "acetylcoenzyme A:deacetylvindoline O-acetyltransferase activity" EXACT [EC:2.3.1.107]
synonym: "DAT activity" EXACT [EC:2.3.1.107]
synonym: "deacetylvindoline acetyltransferase activity" EXACT [EC:2.3.1.107]
synonym: "deacetylvindoline O-acetyltransferase activity" EXACT [EC:2.3.1.107]
xref: EC:2.3.1.107
xref: MetaCyc:2.3.1.107-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047163
name: 3,4-dichloroaniline N-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonate + CoA." [EC:2.3.1.114, MetaCyc:2.3.1.114-RXN]
synonym: "malonyl-CoA:3,4-dichloroaniline N-malonyltransferase activity" EXACT [EC:2.3.1.114]
xref: EC:2.3.1.114
xref: MetaCyc:2.3.1.114-RXN
is_a: GO:0050735 ! N-malonyltransferase activity

[Term]
id: GO:0047164
name: isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: biochanin-A + malonyl-CoA = 6'-malonyl-biochanin A + CoA." [EC:2.3.1.115, MetaCyc:2.3.1.115-RXN]
synonym: "flavone (flavonol) 7-O-glycoside malonyltransferase activity" EXACT [EC:2.3.1.115]
synonym: "flavone/flavonol 7-O-beta-D-glucoside malonyltransferase activity" EXACT [EC:2.3.1.115]
synonym: "malonyl-CoA:flavone/flavonol 7-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.115]
synonym: "malonyl-CoA:isoflavone-7-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.115]
synonym: "malonyl-coenzyme A:flavone/flavonol-7-O-glycoside malonyltransferase activity" EXACT [EC:2.3.1.115]
synonym: "malonyl-coenzyme A:isoflavone 7-O-glucoside-6''-malonyltransferase activity" EXACT [EC:2.3.1.115]
synonym: "MAT-7" RELATED [EC:2.3.1.115]
xref: EC:2.3.1.115
xref: MetaCyc:2.3.1.115-RXN
is_a: GO:0050736 ! O-malonyltransferase activity

[Term]
id: GO:0047165
name: flavonol-3-O-beta-glucoside O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA." [EC:2.3.1.116, MetaCyc:2.3.1.116-RXN]
synonym: "flavonol 3-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.116]
synonym: "malonyl-CoA:flavonol-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" EXACT [EC:2.3.1.116]
synonym: "malonyl-coenzyme A:flavonol-3-O-glucoside malonyltransferase activity" EXACT [EC:2.3.1.116]
synonym: "MAT-3" RELATED [EC:2.3.1.116]
xref: EC:2.3.1.116
xref: MetaCyc:2.3.1.116-RXN
is_a: GO:0050736 ! O-malonyltransferase activity

[Term]
id: GO:0047166
name: 1-alkenylglycerophosphoethanolamine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA." [EC:2.3.1.121, MetaCyc:2.3.1.121-RXN]
synonym: "acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase activity" EXACT [EC:2.3.1.121]
xref: EC:2.3.1.121
xref: MetaCyc:2.3.1.121-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047167
name: 1-alkyl-2-acetylglycerol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-O-alkyl-2-acetyl-sn-glycerol + acyl-CoA = 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA." [EC:2.3.1.125, MetaCyc:2.3.1.125-RXN]
synonym: "1-hexadecyl-2-acetylglycerol acyltransferase activity" EXACT [EC:2.3.1.125]
synonym: "acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.125]
xref: EC:2.3.1.125
xref: MetaCyc:2.3.1.125-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047168
name: isocitrate O-dihydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: threo-d(s)-iso-citrate + caffeoyl-CoA = 2-caffeoylisocitrate + CoA." [EC:2.3.1.126, MetaCyc:2.3.1.126-RXN]
synonym: "caffeoyl-CoA:isocitrate 3-O-(3,4-dihydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.126]
xref: EC:2.3.1.126
xref: MetaCyc:2.3.1.126-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047169
name: galactarate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: feruloyl-CoA + D-galactarate = O-feruloylgalactarate + CoA." [EC:2.3.1.130, MetaCyc:2.3.1.130-RXN]
synonym: "feruloyl-CoA:galactarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.130]
synonym: "galacturate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.130]
xref: EC:2.3.1.130
xref: MetaCyc:2.3.1.130-RXN
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047170
name: glucarate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucarate + sinapoyl-CoA = O-sinapoylglucarate + CoA." [EC:2.3.1.131, MetaCyc:2.3.1.131-RXN]
synonym: "sinapoyl-CoA:glucarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.131]
xref: EC:2.3.1.131
xref: MetaCyc:2.3.1.131-RXN
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047171
name: glucarolactone O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA." [EC:2.3.1.132, MetaCyc:2.3.1.132-RXN]
synonym: "sinapoyl-CoA:glucarolactone O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.132]
xref: EC:2.3.1.132
xref: MetaCyc:2.3.1.132-RXN
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047172
name: shikimate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA." [EC:2.3.1.133, MetaCyc:2.3.1.133-RXN]
synonym: "4-coumaroyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.133]
synonym: "shikimate hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.133]
xref: EC:2.3.1.133
xref: MetaCyc:2.3.1.133-RXN
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047173
name: phosphatidylcholine-retinol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine." [EC:2.3.1.135, MetaCyc:2.3.1.135-RXN]
synonym: "lecithin--retinol acyltransferase activity" EXACT [EC:2.3.1.135]
synonym: "phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase activity" EXACT [EC:2.3.1.135]
synonym: "phosphatidylcholine:retinol-[cellular-retinol-binding-protein] O-acyltransferase activity" EXACT [EC:2.3.1.135]
xref: EC:2.3.1.135
xref: MetaCyc:2.3.1.135-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047174
name: putrescine N-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: putrescine + caffeoyl-CoA = N-caffeoylputrescine + CoA." [EC:2.3.1.138, MetaCyc:2.3.1.138-RXN]
synonym: "caffeoyl-CoA putrescine N-caffeoyl transferase activity" EXACT [EC:2.3.1.138]
synonym: "caffeoyl-CoA:putrescine N-(3,4-dihydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.138]
synonym: "hydroxycinnamoyl-CoA:putrescine hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.138]
synonym: "PHT" RELATED [EC:2.3.1.138]
synonym: "putrescine hydroxycinnamoyl transferase activity" EXACT [EC:2.3.1.138]
synonym: "putrescine hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.138]
xref: EC:2.3.1.138
xref: MetaCyc:2.3.1.138-RXN
is_a: GO:0016410 ! N-acyltransferase activity
is_a: GO:0050734 ! hydroxycinnamoyltransferase activity

[Term]
id: GO:0047175
name: galactosylacylglycerol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]." [EC:2.3.1.141, MetaCyc:2.3.1.141-RXN]
synonym: "acyl-ACP:lyso-MGDG acyltransferase activity" EXACT [EC:2.3.1.141]
synonym: "acyl-acyl-carrier protein: lysomonogalactosyldiacylglycerol acyltransferase activity" EXACT [EC:2.3.1.141]
synonym: "acyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.141]
xref: EC:2.3.1.141
xref: MetaCyc:2.3.1.141-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047176
name: beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + beta-D-glucose." [EC:2.3.1.143, MetaCyc:2.3.1.143-RXN]
synonym: "1-O-galloyl-beta-D-glucose:1,2,3,6-tetrakis-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143]
synonym: "beta-glucogallin-tetragalloylglucose 4-galloyltransferase activity" EXACT [EC:2.3.1.143]
synonym: "beta-glucogallin:1,2,3,6-tetra-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143]
synonym: "beta-glucogallin:1,2,3,6-tetra-O-galloylglucose 4-O-galloyltransferase activity" EXACT [EC:2.3.1.143]
xref: EC:2.3.1.143
xref: MetaCyc:2.3.1.143-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047177
name: glycerophospholipid arachidonoyl-transferase (CoA-independent) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine." [EC:2.3.1.147, MetaCyc:2.3.1.147-RXN]
synonym: "1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" EXACT [EC:2.3.1.147]
synonym: "1-organyl-2-arachidonyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" EXACT [EC:2.3.1.147]
xref: EC:2.3.1.147
xref: MetaCyc:2.3.1.147-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047178
name: glycerophospholipid acyltransferase (CoA-dependent) activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-radyl-2-acyl-sn-glycero-3-phosphocholine = 1-radyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acyl-sn-glycero-3-phosphoethanolamine." [EC:2.3.1.148, MetaCyc:2.3.1.148-RXN]
synonym: "1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent)" EXACT [EC:2.3.1.148]
xref: EC:2.3.1.148
xref: MetaCyc:2.3.1.148-RXN
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0047179
name: platelet-activating factor acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid." [EC:2.3.1.149, MetaCyc:2.3.1.149-RXN]
synonym: "1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phospholipid acetyltransferase activity" EXACT [EC:2.3.1.149]
synonym: "PAF acetyltransferase activity" EXACT []
xref: EC:2.3.1.149
xref: MetaCyc:2.3.1.149-RXN
is_a: GO:0016407 ! acetyltransferase activity

[Term]
id: GO:0047180
name: salutaridinol 7-O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: salutaridinol + acetyl-CoA = 7-O-acetylsalutaridinol + CoA." [EC:2.3.1.150, MetaCyc:2.3.1.150-RXN]
synonym: "acetyl-CoA:salutaridinol 7-O-acetyltransferase activity" EXACT [EC:2.3.1.150]
xref: EC:2.3.1.150
xref: MetaCyc:2.3.1.150-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047181
name: benzophenone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A." [EC:2.3.1.151, MetaCyc:2.3.1.151-RXN]
synonym: "malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase activity" EXACT [EC:2.3.1.151]
xref: EC:2.3.1.151
xref: MetaCyc:2.3.1.151-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047182
name: alcohol O-cinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alcohol + 1-O-trans-cinnamoyl-beta-D-glucopyranose = beta-D-glucose + alkyl cinnamate." [EC:2.3.1.152, MetaCyc:2.3.1.152-RXN]
synonym: "1-O-trans-cinnamoyl-beta-D-glucopyranose:alcohol O-cinnamoyltransferase activity" EXACT [EC:2.3.1.152]
xref: EC:2.3.1.152
xref: MetaCyc:2.3.1.152-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047183
name: anthocyanin 5-aromatic acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoyl-CoA = anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside + CoA." [EC:2.3.1.153, MetaCyc:2.3.1.153-RXN]
synonym: "hydroxycinnamoyl-CoA:anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase activity" EXACT [EC:2.3.1.153]
xref: EC:2.3.1.153
xref: MetaCyc:RXN-7945
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0047184
name: 1-acylglycerophosphocholine O-acyltransferase activity
namespace: molecular_function
alt_id: GO:0000507
def: "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN]
synonym: "1-acyl-sn-glycero-3-phosphocholine acyltransferase activity" EXACT [EC:2.3.1.23]
synonym: "acyl coenzyme A-monoacylphosphatidylcholine acyltransferase activity" EXACT [EC:2.3.1.23]
synonym: "acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase activity" EXACT [EC:2.3.1.23]
synonym: "acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.23]
synonym: "lysolecithin acyltransferase activity" EXACT [EC:2.3.1.23]
synonym: "lysophosphatide acyltransferase activity" EXACT [EC:2.3.1.23]
synonym: "lysophosphatidylcholine acyltransferase activity" EXACT [EC:2.3.1.23]
xref: EC:2.3.1.23
xref: MetaCyc:2.3.1.23-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047185
name: N-acetylneuraminate 4-O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA." [EC:2.3.1.44, MetaCyc:2.3.1.44-RXN]
synonym: "acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase activity" EXACT [EC:2.3.1.44]
synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.44]
xref: EC:2.3.1.44
xref: MetaCyc:2.3.1.44-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047186
name: N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA." [EC:2.3.1.45, MetaCyc:2.3.1.45-RXN]
synonym: "acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "glycoprotein 7(9)-O-acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "N-acetylneuraminate 7(8)-O-acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "N-acetylneuraminate 7,8-O-acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "N-acetylneuraminate O7-(or O9-)acetyltransferase activity" EXACT [EC:2.3.1.45]
synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.45]
xref: EC:2.3.1.45
xref: MetaCyc:2.3.1.45-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047187
name: deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate." [EC:2.3.1.49, MetaCyc:2.3.1.49-RXN]
synonym: "deacetyl-citrate-(pro-3S)-lyase acetyltransferase activity" EXACT [EC:2.3.1.49]
synonym: "deacetyl-citrate-(pro-3S)-lyase S-acetyltransferase activity" EXACT [EC:2.3.1.49]
synonym: "S-acetyl phosphopantetheine:deacetyl citrate lyase S-acetyltransferase activity" EXACT [EC:2.3.1.49]
synonym: "S-acetylphosphopantetheine:deacetyl-citrate-oxaloacetate-lyase((pro-3S)-CH2COO-rightacetate)S-acetyltransferase activity" EXACT [EC:2.3.1.49]
xref: EC:2.3.1.49
xref: MetaCyc:2.3.1.49-RXN
is_a: GO:0016418 ! S-acetyltransferase activity

[Term]
id: GO:0047188
name: aromatic-hydroxylamine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-hydroxy-4-aminobiphenyl + N-hydroxy-4-acetylaminonbiphenyl = N-acetoxy-4-aminobiphenyl + N-hydroxy-4-aminobiphenyl." [EC:2.3.1.56, MetaCyc:2.3.1.56-RXN]
synonym: "aromatic hydroxylamine acetyltransferase activity" EXACT [EC:2.3.1.56]
synonym: "arylhydroxamate acyltransferase activity" EXACT [EC:2.3.1.56]
synonym: "arylhydroxamic acid N,O-acetyltransferase activity" EXACT [EC:2.3.1.56]
synonym: "arylhydroxamic acyltransferase activity" EXACT [EC:2.3.1.56]
synonym: "N,O-acetyltransferase activity" EXACT [EC:2.3.1.56]
synonym: "N-hydroxy-2-acetylaminofluorene N-O acyltransferase activity" EXACT [EC:2.3.1.56]
synonym: "N-hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl O-acetyltransferase activity" EXACT [EC:2.3.1.56]
xref: EC:2.3.1.56
xref: MetaCyc:2.3.1.56-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047189
name: 2,3-diaminopropionate N-oxalyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2,3-diaminopropanoate + oxalyl-CoA = N3-oxalyl-L-23-diaminopropanoate + CoA." [EC:2.3.1.58, MetaCyc:2.3.1.58-RXN]
synonym: "ODAP synthase activity" EXACT [EC:2.3.1.58]
synonym: "oxalyl-CoA:L-2,3-diaminopropanoate 3-N-oxalyltransferase activity" EXACT [EC:2.3.1.58]
synonym: "oxalyl-CoA:L-2,3-diaminopropanoate N3-oxalyltransferase activity" EXACT [EC:2.3.1.58]
synonym: "oxalyl-CoA:L-alpha,beta-diaminopropionic acid oxalyltransferase activity" EXACT [EC:2.3.1.58]
synonym: "oxalyldiaminopropionate synthase activity" EXACT [EC:2.3.1.58]
synonym: "oxalyldiaminopropionic synthase activity" EXACT [EC:2.3.1.58]
xref: EC:2.3.1.58
xref: MetaCyc:2.3.1.58-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047190
name: 2-acylglycerophosphocholine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.62, MetaCyc:2.3.1.62-RXN]
synonym: "2-acylglycerol-3-phosphorylcholine acyltransferase activity" EXACT [EC:2.3.1.62]
synonym: "2-acylglycerophosphocholine acyltransferase activity" EXACT [EC:2.3.1.62]
synonym: "acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.62]
xref: EC:2.3.1.62
xref: MetaCyc:2.3.1.62-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047191
name: 1-alkylglycerophosphocholine O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.63, MetaCyc:2.3.1.63-RXN]
synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase activity" EXACT [EC:2.3.1.63]
xref: EC:2.3.1.63
xref: MetaCyc:2.3.1.63-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047192
name: 1-alkylglycerophosphocholine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.67, MetaCyc:2.3.1.67-RXN]
synonym: "1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity" EXACT [EC:2.3.1.67]
synonym: "1-alkyl-2-lysolecithin acetyltransferase activity" EXACT [EC:2.3.1.67]
synonym: "acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity" EXACT [EC:2.3.1.67]
synonym: "acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity" EXACT [EC:2.3.1.67]
synonym: "acetyl-CoA:lyso-PAF acetyltransferase activity" EXACT [EC:2.3.1.67]
synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase activity" EXACT [EC:2.3.1.67]
synonym: "blood platelet-activating factor acetyltransferase activity" BROAD [EC:2.3.1.67]
synonym: "lyso-GPC:acetyl CoA acetyltransferase activity" BROAD [EC:2.3.1.67]
synonym: "lyso-platelet activating factor:acetyl-CoA acetyltransferase activity" BROAD [EC:2.3.1.67]
synonym: "lyso-platelet-activating factor:acetyl-CoA acetyltransferase activity" BROAD [EC:2.3.1.67]
synonym: "lysoPAF:acetyl CoA acetyltransferase activity" EXACT [EC:2.3.1.67]
synonym: "lysopaf:acetyl CoA acetyltransferase activity" BROAD [EC:2.3.1.67]
synonym: "platelet-activating factor acylhydrolase activity" BROAD [EC:2.3.1.67]
synonym: "platelet-activating factor-synthesizing enzyme activity" BROAD [EC:2.3.1.67]
xref: EC:2.3.1.67
xref: MetaCyc:2.3.1.67-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047193
name: CDP-acylglycerol O-arachidonoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-acylglycerol + arachidonyl-CoA = CDP-diacylglycerol + CoA." [EC:2.3.1.70, MetaCyc:2.3.1.70-RXN]
synonym: "arachidonoyl-CoA:CDP-acylglycerol O-arachidonoyltransferase activity" EXACT [EC:2.3.1.70]
synonym: "arachidonyl-CoA:CDP-acylglycerol O-arachidonyltransferase activity" EXACT [EC:2.3.1.70]
synonym: "CDP-acylglycerol O-arachidonyltransferase activity" EXACT []
synonym: "CDPacylglycerol O-arachidonyltransferase activity" EXACT [EC:2.3.1.70]
xref: EC:2.3.1.70
xref: MetaCyc:2.3.1.70-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047194
name: indoleacetylglucose-inositol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol + indole-3-acetyl-beta-1-D-glucose = indole-3-acetyl-myo-inositol + beta-D-glucose." [EC:2.3.1.72, MetaCyc:2.3.1.72-RXN]
synonym: "1-O-(indol-3-yl)acetyl-beta-D-glucose:myo-inositol (indol-3-yl)acetyltransferase activity" EXACT [EC:2.3.1.72]
synonym: "1-O-(indol-3-ylacetyl)-beta-D-glucose:myo-inositol indole-3-ylacetyltransferase activity" EXACT [EC:2.3.1.72]
synonym: "indole-3-acetyl-beta-1-D-glucoside:myo-inositol indoleacetyltransferase activity" EXACT [EC:2.3.1.72]
xref: EC:2.3.1.72
xref: MetaCyc:2.3.1.72-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047195
name: diacylglycerol-sterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol." [EC:2.3.1.73, MetaCyc:2.3.1.73-RXN]
synonym: "1,2-diacyl-sn-glycerol:sterol acyl transferase activity" EXACT [EC:2.3.1.73]
synonym: "1,2-diacyl-sn-glycerol:sterol O-acyltransferase activity" EXACT [EC:2.3.1.73]
xref: EC:2.3.1.73
xref: MetaCyc:2.3.1.73-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047196
name: long-chain-alcohol O-fatty-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA." [EC:2.3.1.75, MetaCyc:2.3.1.75-RXN]
synonym: "acyl-CoA:long-chain-alcohol O-acyltransferase activity" EXACT [EC:2.3.1.75]
synonym: "wax synthase activity" RELATED [EC:2.3.1.75]
synonym: "wax-ester synthase activity" EXACT [EC:2.3.1.75]
xref: EC:2.3.1.75
xref: MetaCyc:2.3.1.75-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047197
name: triglyceride-sterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol." [EC:2.3.1.77, MetaCyc:2.3.1.77-RXN]
synonym: "triacylglycerol-sterol O-acyltransferase activity" EXACT [GOC:curators]
synonym: "triacylglycerol:3beta-hydroxysterol O-acyltransferase activity" EXACT [EC:2.3.1.77]
synonym: "triacylglycerol:sterol acyltransferase activity" EXACT [EC:2.3.1.77]
xref: EC:2.3.1.77
xref: MetaCyc:2.3.1.77-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047198
name: cysteine-S-conjugate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an S-substituted L-cysteine + acetyl-CoA = an S-substituted N-acetyl-L-cysteine + CoA." [EC:2.3.1.80, MetaCyc:2.3.1.80-RXN]
synonym: "acetyl-CoA:S-substituted L-cysteine N-acetyltransferase activity" EXACT [EC:2.3.1.80]
xref: EC:2.3.1.80
xref: MetaCyc:2.3.1.80-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047199
name: phosphatidylcholine-dolichol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichol + phosphatidylcholine = acyldolichol + 1-acyl-sn-glycero-3-phosphocholine." [EC:2.3.1.83, MetaCyc:2.3.1.83-RXN]
synonym: "3-sn-phosphatidylcholine:dolichol O-acyltransferase activity" EXACT [EC:2.3.1.83]
xref: EC:2.3.1.83
xref: MetaCyc:2.3.1.83-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047200
name: tetrahydrodipicolinate N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA = L-2-acetamido-6-oxoheptanedioate + CoA." [EC:2.3.1.89, MetaCyc:2.3.1.89-RXN]
subset: gosubset_prok
synonym: "acetyl-CoA:(S)-2,3,4,5-tetrahydrodipicolinate-2,6-dicarboxylate N2-acetyltransferase activity" EXACT [EC:2.3.1.89]
synonym: "acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate 2-N-acetyltransferase activity" EXACT [EC:2.3.1.89]
synonym: "acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase activity" EXACT [EC:2.3.1.89]
synonym: "tetrahydrodipicolinate acetylase activity" EXACT [EC:2.3.1.89]
synonym: "tetrahydrodipicolinate:acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.89]
xref: EC:2.3.1.89
xref: MetaCyc:2.3.1.89-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047201
name: beta-glucogallin O-galloyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1-O,6-O-digalloyl-beta-D-glucose + beta-D-glucose." [EC:2.3.1.90, MetaCyc:2.3.1.90-RXN]
synonym: "1-O-galloyl-beta-D-glucose:1-O-galloyl-beta-D-glucose O-galloyltransferase activity" EXACT [EC:2.3.1.90]
xref: EC:2.3.1.90
xref: MetaCyc:2.3.1.90-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047202
name: sinapoylglucose-choline O-sinapoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: choline + 1-O-sinapoyl-beta-D-glucose = O-sinapoylcholine + beta-D-glucose." [EC:2.3.1.91, MetaCyc:2.3.1.91-RXN]
synonym: "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucose:choline 1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)transferase activity" EXACT [EC:2.3.1.91]
synonym: "sinapine synthase activity" EXACT [EC:2.3.1.91]
xref: EC:2.3.1.91
xref: MetaCyc:2.3.1.91-RXN
is_a: GO:0016753 ! O-sinapoyltransferase activity

[Term]
id: GO:0047203
name: 13-hydroxylupinine O-tigloyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 13-hydroxylupinine + (E)-2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyl)oxylupinine + CoA." [EC:2.3.1.93, MetaCyc:2.3.1.93-RXN]
synonym: "(E)-2-methylcrotonoyl-CoA:13-hydroxylupinine O-2-methylcrotonoyltransferase activity" EXACT [EC:2.3.1.93]
synonym: "13-hydroxylupanine acyltransferase activity" EXACT [EC:2.3.1.93]
synonym: "tigloyl-CoA:13-hydroxylupanine O-tigloyltransferase activity" EXACT [EC:2.3.1.93]
xref: EC:2.3.1.93
xref: MetaCyc:2.3.1.93-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047204
name: chlorogenate-glucarate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucarate + chlorogenate = 2-O-caffeoylglucarate + quinate." [EC:2.3.1.98, MetaCyc:2.3.1.98-RXN]
synonym: "chlorogenate:glucarate caffeoyltransferase activity" EXACT [EC:2.3.1.98]
synonym: "chlorogenate:glucarate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.98]
synonym: "chlorogenic acid:glucaric acid O-caffeoyltransferase activity" EXACT [EC:2.3.1.98]
xref: EC:2.3.1.98
xref: MetaCyc:2.3.1.98-RXN
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047205
name: quinate O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA." [EC:2.3.1.99, MetaCyc:2.3.1.99-RXN]
synonym: "feruloyl-CoA:quinate O-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.99]
synonym: "hydroxycinnamoyl coenzyme A-quinate transferase activity" EXACT [EC:2.3.1.99]
xref: EC:2.3.1.99
xref: MetaCyc:2.3.1.99-RXN
is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity

[Term]
id: GO:0047206
name: UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA." [EC:2.3.2.10, MetaCyc:2.3.2.10-RXN]
synonym: "alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase activity" EXACT [EC:2.3.2.10]
synonym: "L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase activity" EXACT [EC:2.3.2.10]
synonym: "L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase activity" EXACT [EC:2.3.2.10]
synonym: "UDP-N-acetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity" EXACT [EC:2.3.2.10]
synonym: "UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase activity" EXACT [EC:2.3.2.10]
synonym: "uridine diphosphoacetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity" EXACT [EC:2.3.2.10]
synonym: "uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase activity" EXACT [EC:2.3.2.10]
xref: EC:2.3.2.10
xref: MetaCyc:2.3.2.10-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0047207
name: 1,2-beta-fructan 1F-fructosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1,2-beta-D-fructosyl)(n) + (1,2-beta-D-fructosyl)(m) = (1,2-beta-D-fructosyl)(n+1) + (1,2-beta-D-fructosyl)(m-1)." [EC:2.4.1.100, MetaCyc:2.4.1.100-RXN]
synonym: "1,2-beta-D-fructan 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.100]
synonym: "1,2-beta-D-fructan 1F-fructosyltransferase activity" EXACT [EC:2.4.1.100]
synonym: "1,2-beta-D-fructan:1,2-beta-D-fructan 1(F)-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100]
synonym: "1,2-beta-D-fructan:1,2-beta-D-fructan 1F-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100]
synonym: "1,2-beta-fructan 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.100]
synonym: "2,1-beta-D-fructan:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.100]
synonym: "2,1-fructan:2,1-fructan 1-fructosyltransferase activity" EXACT [EC:2.4.1.100]
synonym: "FFT activity" EXACT [EC:2.4.1.100]
synonym: "fructan:fructan fructosyl transferase activity" EXACT [EC:2.4.1.100]
xref: EC:2.4.1.100
xref: MetaCyc:2.4.1.100-RXN
is_a: GO:0050738 ! fructosyltransferase activity

[Term]
id: GO:0047208
name: o-dihydroxycoumarin 7-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + UDP." [EC:2.4.1.104, MetaCyc:2.4.1.104-RXN]
synonym: "UDP-glucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.104]
synonym: "UDP-glucose:o-dihydroxycoumarin glucosyltransferase activity" EXACT [EC:2.4.1.104]
synonym: "UDPglucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.104]
synonym: "uridine diphosphoglucose-o-dihydroxycoumarin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.104]
xref: EC:2.4.1.104
xref: MetaCyc:2.4.1.104-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047209
name: coniferyl-alcohol glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: coniferyl alcohol + UDP-D-glucose = coniferin + UDP." [EC:2.4.1.111, MetaCyc:2.4.1.111-RXN]
synonym: "UDP-glucose coniferyl alcohol glucosyltransferase activity" EXACT [EC:2.4.1.111]
synonym: "UDP-glucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.111]
synonym: "UDPglucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.111]
synonym: "uridine diphosphoglucose-coniferyl alcohol glucosyltransferase activity" EXACT [EC:2.4.1.111]
xref: EC:2.4.1.111
xref: MetaCyc:2.4.1.111-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047211
name: alpha-1,4-glucan-protein synthase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-D-glucose + protein = alpha-D-glucosyl-protein + ADP." [EC:2.4.1.113, MetaCyc:2.4.1.113-RXN]
synonym: "1,4alpha-glucan-protein synthase (ADP-forming) activity" EXACT []
synonym: "adenosine diphosphoglucose-protein glucosyltransferase activity" EXACT [EC:2.4.1.113]
synonym: "ADP-glucose:protein 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.113]
synonym: "ADPglucose:protein 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.113]
synonym: "ADPglucose:protein glucosyltransferase activity" EXACT [EC:2.4.1.113]
xref: EC:2.4.1.113
xref: MetaCyc:2.4.1.113-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047212
name: 2-coumarate O-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + UDP." [EC:2.4.1.114, MetaCyc:2.4.1.114-RXN]
synonym: "UDP-glucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.114]
synonym: "UDPG:o-coumaric acid O-glucosyltransferase activity" EXACT [EC:2.4.1.114]
synonym: "UDPglucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.114]
synonym: "uridine diphosphoglucose-o-coumarate glucosyltransferase activity" EXACT [EC:2.4.1.114]
xref: EC:2.4.1.114
xref: MetaCyc:2.4.1.114-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047213
name: anthocyanidin 3-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP." [EC:2.4.1.115, MetaCyc:2.4.1.115-RXN]
synonym: "3-GT activity" EXACT [EC:2.4.1.115]
synonym: "UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.115]
synonym: "UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.115]
synonym: "UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115]
synonym: "UDP-glucose:cyanidin-3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115]
synonym: "uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.115]
xref: EC:2.4.1.115
xref: MetaCyc:2.4.1.115-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047214
name: cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyanidin-3-O-D-rhamnosyl-(1,6)-D-glucoside + UDP-D-glucose = cyanidin-3-O-[D-rhamnosyl-(1,6)-D-glucoside]-5-O-D-glucoside + UDP." [EC:2.4.1.116, MetaCyc:2.4.1.116-RXN]
synonym: "cyanidin-3-O-rutinoside 5-O-glucosyltransferase activity" EXACT [EC:2.4.1.116]
synonym: "UDP-glucose:cyanidin-3-O-beta-L-rhamnosyl-(1->6)-beta-D-glucoside 5-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.116]
synonym: "UDP-glucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside 5-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.116]
synonym: "uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase activity" EXACT [EC:2.4.1.116]
xref: EC:2.4.1.116
xref: MetaCyc:2.4.1.116-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047215
name: indole-3-acetate beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: auxin + UDP-D-glucose = indole-3-acetyl-beta-1-D-glucose + UDP." [EC:2.4.1.121, MetaCyc:2.4.1.121-RXN]
synonym: "IAA-Glu synthetase activity" EXACT [EC:2.4.1.121]
synonym: "IAA-glucose synthase activity" EXACT [EC:2.4.1.121]
synonym: "IAGlu synthase activity" EXACT [EC:2.4.1.121]
synonym: "indol-3-ylacetylglucose synthase activity" EXACT [EC:2.4.1.121]
synonym: "UDP-glucose:(indol-3-yl)acetate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.121]
synonym: "UDP-glucose:indol-3-ylacetate glucosyl-transferase activity" EXACT [EC:2.4.1.121]
synonym: "UDP-glucose:indol-3-ylacetate glucosyltransferase activity" EXACT [EC:2.4.1.121]
synonym: "UDPG-indol-3-ylacetyl glucosyl transferase activity" EXACT [EC:2.4.1.121]
synonym: "UDPglucose:indole-3-acetate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.121]
synonym: "uridine diphosphoglucose-indoleacetate glucosyltransferase activity" EXACT [EC:2.4.1.121]
xref: EC:2.4.1.121
xref: MetaCyc:2.4.1.121-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047216
name: inositol 3-alpha-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP." [EC:2.4.1.123, MetaCyc:2.4.1.123-RXN]
synonym: "galactinol synthase activity" EXACT [EC:2.4.1.123]
synonym: "inositol 1-alpha-galactosyltransferase activity" EXACT []
synonym: "UDP-D-galactose:inositol galactosyltransferase activity" EXACT [EC:2.4.1.123]
synonym: "UDP-galactose:myo-inositol 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123]
synonym: "UDP-galactose:myo-inositol 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123]
synonym: "UDPgalactose:myo-inositol 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.123]
synonym: "uridine diphosphogalactose-inositol galactosyltransferase activity" EXACT [EC:2.4.1.123]
xref: EC:2.4.1.123
xref: MetaCyc:2.4.1.123-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047217
name: sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = 1,6-alpha-D-glucosyl(n+1) + fructose." [EC:2.4.1.125, MetaCyc:2.4.1.125-RXN]
synonym: "GTF-S" RELATED [EC:2.4.1.125]
synonym: "sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase" BROAD [EC:2.4.1.125]
synonym: "sucrose:1,6-alpha-D-glucan 3(6)-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.125]
synonym: "sucrose:1,6-alpha-D-glucan 3-alpha- and 6-alpha-glucosyltransferase activity" EXACT [EC:2.4.1.125]
synonym: "water-soluble-glucan synthase activity" RELATED [EC:2.4.1.125]
xref: EC:2.4.1.125
xref: MetaCyc:2.4.1.125-RXN
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0047218
name: hydroxycinnamate 4-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP." [EC:2.4.1.126, MetaCyc:2.4.1.126-RXN]
synonym: "hydroxycinnamoyl glucosyltransferase activity" EXACT [EC:2.4.1.126]
synonym: "UDP-glucose-hydroxycinnamate glucosyltransferase activity" EXACT [EC:2.4.1.126]
synonym: "UDP-glucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.126]
synonym: "UDPglucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.126]
synonym: "uridine diphosphoglucose-hydroxycinnamate glucosyltransferase activity" EXACT [EC:2.4.1.126]
xref: EC:2.4.1.126
xref: MetaCyc:2.4.1.126-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047219
name: monoterpenol beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl O-beta-D-glucoside + UDP." [EC:2.4.1.127, MetaCyc:2.4.1.127-RXN]
synonym: "UDP-glucose:(-)-menthol O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.127]
synonym: "UDPglucose:(-)-menthol O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.127]
synonym: "UDPglucose:monoterpenol glucosyltransferase activity" EXACT [EC:2.4.1.127]
synonym: "uridine diphosphoglucose-monoterpenol glucosyltransferase activity" EXACT [EC:2.4.1.127]
xref: EC:2.4.1.127
xref: MetaCyc:2.4.1.127-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047220
name: galactosylxylosylprotein 3-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP." [EC:2.4.1.134, MetaCyc:2.4.1.134-RXN]
synonym: "galactosyltransferase II activity" RELATED [EC:2.4.1.134]
synonym: "UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.134]
synonym: "UDPgalactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.134]
synonym: "uridine diphosphogalactose-galactosylxylose galactosyltransferase activity" EXACT [EC:2.4.1.134]
xref: EC:2.4.1.134
xref: MetaCyc:2.4.1.134-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047221
name: sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol-3-phosphate + UDP-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + UDP." [EC:2.4.1.137, MetaCyc:2.4.1.137-RXN]
synonym: "floridoside phosphate synthase activity" EXACT [EC:2.4.1.137]
synonym: "floridoside phosphate synthetase activity" EXACT [EC:2.4.1.137]
synonym: "floridoside-phosphate synthase activity" EXACT [EC:2.4.1.137]
synonym: "FPS" RELATED [EC:2.4.1.137]
synonym: "UDP-galactose, sn-3-glycerol phosphate:1->2' galactosyltransferase activity" EXACT [EC:2.4.1.137]
synonym: "UDP-galactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.137]
synonym: "UDP-galactose:sn-glycerol-3-phosphate-2-D-galactosyl transferase activity" EXACT [EC:2.4.1.137]
synonym: "UDPgalactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.137]
xref: EC:2.4.1.137
xref: MetaCyc:2.4.1.137-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047222
name: mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose + UDP-N-acetyl-D-glucosamine = 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose + UDP." [EC:2.4.1.138, MetaCyc:2.4.1.138-RXN]
synonym: "alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.138]
synonym: "UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.138]
synonym: "uridine diphosphoacetylglucosamine mannoside alpha1->2-alphacetylglucosaminyltransferase activity" EXACT [EC:2.4.1.138]
xref: EC:2.4.1.138
xref: MetaCyc:2.4.1.138-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047223
name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.146, MetaCyc:2.4.1.146-RXN]
synonym: "elongation 3-beta-GalNAc-transferase activity" RELATED [EC:2.4.1.146]
synonym: "elongation 3beta-GalNAc-transferase activity" EXACT [EC:2.4.1.146]
synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.146]
synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to -D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.146]
synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating)" EXACT [EC:2.4.1.146]
xref: EC:2.4.1.146
xref: MetaCyc:2.4.1.146-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047224
name: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.147, MetaCyc:2.4.1.147-RXN]
synonym: "core 3-beta-GlcNAc-transferase activity" RELATED [EC:2.4.1.147]
synonym: "core 3beta-GlcNAc-transferase activity" EXACT [EC:2.4.1.147]
synonym: "mucin core 3 beta3-GlcNAc-transferase activity" EXACT [EC:2.4.1.147]
synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.147]
synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.147]
synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.147]
xref: EC:2.4.1.147
xref: MetaCyc:2.4.1.147-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047225
name: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.148, MetaCyc:2.4.1.148-RXN]
synonym: "core 4 beta6-GalNAc-transferase activity" EXACT [EC:2.4.1.148]
synonym: "core 6-beta-GalNAc-transferase B activity" RELATED [EC:2.4.1.148]
synonym: "core 6beta-GalNAc-transferase B" RELATED [EC:2.4.1.148]
synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.148]
synonym: "UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.148]
synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->6)-acetylglucosaminyltransferase B" RELATED [EC:2.4.1.148]
xref: EC:2.4.1.148
xref: MetaCyc:2.4.1.148-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047227
name: indolylacetyl-myo-inositol galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetyl-myo-inositol + UDP-galactose = 5-O-(indol-3-ylacetyl-myo-inositol)-D-galactoside + UDP." [EC:2.4.1.156, MetaCyc:2.4.1.156-RXN]
synonym: "indol-3-ylacetyl-myo-inositol galactoside synthase activity" EXACT [EC:2.4.1.156]
synonym: "UDP-galactose:(indol-3-yl)acetyl-myo-inositol 5-O-D-galactosyltransferase activity" EXACT [EC:2.4.1.156]
synonym: "UDP-galactose:indol-3-ylacetyl-myo-inositol 5-O-D-galactosyltransferase activity" EXACT [EC:2.4.1.156]
synonym: "uridine diphosphogalactose-indolylacetylinositol galactosyltransferase activity" EXACT [EC:2.4.1.156]
xref: EC:2.4.1.156
xref: MetaCyc:2.4.1.156-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047228
name: 1,2-diacylglycerol 3-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacylglycerol + UDP-D-glucose = 3-D-glucosyl-1,2-diacylglycerol + UDP." [EC:2.4.1.157, MetaCyc:2.4.1.157-RXN]
subset: gosubset_prok
synonym: "UDP-glucose-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157]
synonym: "UDP-glucose:1,2-diacylglycerol 3-D-glucosyltransferase activity" EXACT [EC:2.4.1.157]
synonym: "UDP-glucose:1,2-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157]
synonym: "UDPglucose:1,2-diacylglycerol 3-D-glucosyltransferase activity" EXACT [EC:2.4.1.157]
synonym: "UDPglucose:diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157]
synonym: "uridine diphosphoglucose-diacylglycerol glucosyltransferase activity" EXACT [EC:2.4.1.157]
xref: EC:2.4.1.157
xref: MetaCyc:2.4.1.157-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047229
name: 13-hydroxydocosanoate 13-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 13-hydroxydocosanoate + UDP-D-glucose = 13-beta-D-glucosyloxydocosanoate + UDP." [EC:2.4.1.158, MetaCyc:2.4.1.158-RXN]
synonym: "13-glucosyloxydocosanoate 2'-beta-glucosyltransferase activity" EXACT [EC:2.4.1.158]
synonym: "UDP-glucose-13-hydroxydocosanoate glucosyltransferase activity" EXACT [EC:2.4.1.158]
synonym: "UDP-glucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.158]
synonym: "UDP-glucose:13-hydroxydocosanoic acid glucosyltransferase activity" EXACT [EC:2.4.1.158]
synonym: "UDPglucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.158]
synonym: "uridine diphosphoglucose-hydroxydocosanoate glucosyltransferase activity" EXACT [EC:2.4.1.158]
xref: EC:2.4.1.158
xref: MetaCyc:HYDROXYDOCOSANOATE-TRANS-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047230
name: flavonol-3-O-glucoside L-rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: flavonol 3-O-D-glucoside + UDP-L-rhamnose = flavonol 3-O-L-rhamnosylglucoside + UDP." [EC:2.4.1.159, MetaCyc:2.4.1.159-RXN]
synonym: "UDP-L-rhamnose:flavonol-3-O-D-glucoside 6''-O-L-rhamnosyltransferase activity" EXACT [EC:2.4.1.159]
synonym: "UDP-rhamnose:flavonol 3-O-glucoside rhamnosyltransferase activity" EXACT [EC:2.4.1.159]
synonym: "uridine diphosphorhamnose-flavonol 3-O-glucoside rhamnosyltransferase activity" EXACT [EC:2.4.1.159]
xref: EC:2.4.1.159
xref: MetaCyc:2.4.1.159-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047231
name: pyridoxine 5'-O-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxine + UDP-D-glucose = 5'-O-beta-D-glucosylpyridoxine + UDP." [EC:2.4.1.160, MetaCyc:2.4.1.160-RXN]
synonym: "UDP-glucose-pyridoxine glucosyltransferase activity" EXACT [EC:2.4.1.160]
synonym: "UDP-glucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.160]
synonym: "UDP-glucose:pyridoxine 5'-O-beta-glucosyltransferase activity" EXACT [EC:2.4.1.160]
synonym: "UDPglucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.160]
synonym: "uridine diphosphoglucose-pyridoxine 5'-beta-glucosyltransferase activity" EXACT [EC:2.4.1.160]
xref: EC:2.4.1.160
xref: MetaCyc:2.4.1.160-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047232
name: galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyceramide + UDP." [EC:2.4.1.164, MetaCyc:2.4.1.164-RXN]
synonym: "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.164]
synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.164]
xref: EC:2.4.1.164
xref: MetaCyc:2.4.1.164-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047233
name: N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-beta-D-galactosaminyl-1,4-(N-acetyl-alpha-neuraminyl-2,3)-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP." [EC:2.4.1.165, MetaCyc:2.4.1.165-RXN]
synonym: "UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.165]
synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.165]
xref: EC:2.4.1.165
xref: MetaCyc:2.4.1.165-RXN
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0047234
name: raffinose-raffinose alpha-galactotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose." [EC:2.4.1.166, MetaCyc:2.4.1.166-RXN]
subset: gosubset_prok
synonym: "raffinose (raffinose donor) galactosyltransferase activity" EXACT [EC:2.4.1.166]
synonym: "raffinose-raffinose a-galactosyltransferase activity" EXACT []
synonym: "raffinose-raffinose alpha-galactosyltransferase activity" EXACT []
synonym: "raffinose:raffinose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.166]
synonym: "raffinose:raffinose alpha-galactosyltransferase activity" EXACT [EC:2.4.1.166]
xref: EC:2.4.1.166
xref: MetaCyc:2.4.1.166-RXN
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0047235
name: sucrose 6F-alpha-galactotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + UDP-galactose = 6F-alpha-D-galactosylsucrose + UDP." [EC:2.4.1.167, MetaCyc:2.4.1.167-RXN]
synonym: "sucrose 6(F)-alpha-galactosyltransferase activity" EXACT []
synonym: "sucrose 6F-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167]
synonym: "UDP-galactose:sucrose 6F-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.167]
synonym: "UDPgalactose:sucrose 6F-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.167]
synonym: "UDPgalactose:sucrose 6fru-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167]
synonym: "uridine diphosphogalactose-sucrose 6F-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.167]
xref: EC:2.4.1.167
xref: MetaCyc:2.4.1.167-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047236
name: methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CH(3)-N(O)=N-CH(2)OH + UDP-D-glucose = cycasin + UDP." [EC:2.4.1.171, MetaCyc:2.4.1.171-RXN]
synonym: "cycasin synthase activity" EXACT [EC:2.4.1.171]
synonym: "methyl-ONN-azoxymethanol glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.171]
synonym: "UDPglucose-methylazoxymethanol glucosyltransferase activity" EXACT [EC:2.4.1.171]
synonym: "uridine diphosphoglucose-methylazoxymethanol glucosyltransferase activity" EXACT [EC:2.4.1.171]
xref: EC:2.4.1.171
xref: MetaCyc:2.4.1.171-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047237
name: glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP." [EC:2.4.1.174, MetaCyc:2.4.1.174-RXN]
synonym: "glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT []
synonym: "N-acetylgalactosaminyltransferase I activity" EXACT []
synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-proteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.174]
synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I" RELATED [EC:2.4.1.174]
synonym: "uridine diphosphoacetylgalactosamine-chondroitinacetylgalactosaminyltransferase I activity" EXACT [EC:2.4.1.174]
xref: EC:2.4.1.174
xref: MetaCyc:2.4.1.174-RXN
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0047238
name: glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP." [EC:2.4.1.175, MetaCyc:2.4.1.175-RXN]
synonym: "chondroitin synthase activity" EXACT [EC:2.4.1.175]
synonym: "glucuronyl-N-acetylgalactosaminylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" EXACT []
synonym: "glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT []
synonym: "N-acetylgalactosaminyltransferase II activity" EXACT []
synonym: "UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.175]
synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.175]
synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity" EXACT [EC:2.4.1.175]
xref: EC:2.4.1.175
xref: MetaCyc:2.4.1.175-RXN
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0047239
name: hydroxymandelonitrile glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxymandelonitrile + UDP-D-glucose = taxiphyllin + UDP." [EC:2.4.1.178, MetaCyc:2.4.1.178-RXN]
synonym: "cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.178]
synonym: "UDP-glucose:4-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.178]
synonym: "UDPglucose:4-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.178]
xref: EC:2.4.1.178
xref: MetaCyc:2.4.1.178-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047240
name: lactosylceramide beta-1,3-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosyl-1,4-beta-D-glucosyl-R + UDP-galactose = D-galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R + UDP." [EC:2.4.1.179, MetaCyc:2.4.1.179-RXN]
synonym: "UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.179]
synonym: "UDPgalactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.179]
synonym: "uridine diphosphogalactose-lactosylceramide beta1->3-galactosyltransferase activity" EXACT [EC:2.4.1.179]
xref: EC:2.4.1.179
xref: MetaCyc:2.4.1.179-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity
is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity

[Term]
id: GO:0047241
name: lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP." [EC:2.4.1.180, MetaCyc:2.4.1.180-RXN]
synonym: "LPS N-acetylmannosaminouronosyltransferase activity" EXACT []
synonym: "ManNAcA transferase activity" EXACT [EC:2.4.1.180]
synonym: "UDP-N-acetyl-beta-D-mannosaminouronate:lipopolysaccharide N-acetyl-beta-D-mannosaminouronosyltransferase activity" EXACT [EC:2.4.1.180]
synonym: "uridine diphosphoacetylmannosaminuronate-acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase activity" EXACT [EC:2.4.1.180]
xref: EC:2.4.1.180
xref: MetaCyc:2.4.1.180-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047242
name: hydroxyanthraquinone glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP." [EC:2.4.1.181, MetaCyc:2.4.1.181-RXN]
synonym: "anthraquinone-specific glucosyltransferase activity" EXACT [EC:2.4.1.181]
synonym: "UDP-glucose:hydroxyanthraquinone O-glucosyltransferase activity" EXACT [EC:2.4.1.181]
synonym: "UDPglucose:hydroxyanthraquinone O-glucosyltransferase activity" EXACT [EC:2.4.1.181]
synonym: "uridine diphosphoglucose-anthraquinone glucosyltransferase activity" EXACT [EC:2.4.1.181]
xref: EC:2.4.1.181
xref: MetaCyc:2.4.1.181-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047243
name: flavanone 7-O-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a flavanone + UDP-D-glucose = a flavanone 7-O-beta-D-glucoside + UDP." [EC:2.4.1.185, MetaCyc:2.4.1.185-RXN]
synonym: "hesperetin 7-O-glucosyl-transferase activity" EXACT [EC:2.4.1.185]
synonym: "naringenin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.185]
synonym: "UDP-glucose:flavanone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.185]
synonym: "UDPglucose:flavanone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.185]
synonym: "uridine diphosphoglucose-flavanone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.185]
xref: EC:2.4.1.185
xref: MetaCyc:2.4.1.185-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047244
name: N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-N-acetyl-D-mannosamine = N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP." [EC:2.4.1.187, MetaCyc:2.4.1.187-RXN]
subset: gosubset_prok
synonym: "N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187]
synonym: "UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol beta-1,4-N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187]
synonym: "UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187]
synonym: "uridine diphosphoacetyl-mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase activity" EXACT [EC:2.4.1.187]
xref: EC:2.4.1.187
xref: MetaCyc:TEICHOICSYN2-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047245
name: N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-D-glucose = beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP." [EC:2.4.1.188, MetaCyc:2.4.1.188-RXN]
synonym: "UDP-D-glucose:N-acetylglucosaminyl pyrophosphorylundecaprenol glucosyltransferase activity" EXACT [EC:2.4.1.188]
synonym: "UDP-glucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.188]
synonym: "UDPglucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.188]
synonym: "uridine diphosphoglucose-acetylglucosaminylpyrophosphorylundecaprenol glucosyltransferase activity" EXACT [EC:2.4.1.188]
xref: EC:2.4.1.188
xref: MetaCyc:2.4.1.188-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047246
name: luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: luteolin 7-O-glucuronide + UDP-D-glucuronate = luteolin 7-O-beta-D-diglucuronide + UDP." [EC:2.4.1.190, MetaCyc:2.4.1.190-RXN]
synonym: "LMT activity" RELATED [EC:2.4.1.190]
synonym: "luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.190]
synonym: "UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase activity" EXACT [EC:2.4.1.190]
synonym: "UDP-glucuronate:luteolin-7-O-beta-D-glucuronide 2''-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.190]
synonym: "uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase activity" EXACT [EC:2.4.1.190]
xref: EC:2.4.1.190
xref: MetaCyc:2.4.1.190-RXN
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0047247
name: luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: luteolin 7-O-beta-D-glucuronide + UDP-D-glucuronate = luteolin 7-O-[beta-D-glucuronosyl-(1,2)-beta-D-glucuronide]-4'-O-beta-D-glucuronide + UDP." [EC:2.4.1.191, MetaCyc:2.4.1.191-RXN]
synonym: "LDT" RELATED [EC:2.4.1.191]
synonym: "UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase activity" EXACT [EC:2.4.1.191]
synonym: "UDP-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.191]
synonym: "UDPglucuronate:luteolin 7-O-diglucuronide-4'-O-glucuronosyl-transferase activity" EXACT [EC:2.4.1.191]
synonym: "UDPglucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.191]
synonym: "uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase activity" EXACT [EC:2.4.1.191]
xref: EC:2.4.1.191
xref: MetaCyc:2.4.1.191-RXN
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0047248
name: nuatigenin 3-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (20S,22S,25S)-22,25-epoxyfurost-5-ene-3-beta,26-diol + UDP-D-glucose = (20S,22S,25S)-22,25-epoxyfurost-5-ene-3-beta,26-diol 3-O-beta-D-glucoside + UDP." [EC:2.4.1.192, MetaCyc:2.4.1.192-RXN]
synonym: "nuatigenin 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.192]
synonym: "UDP-glucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.192]
synonym: "UDPglucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.192]
synonym: "uridine diphosphoglucose-nuatigenin glucosyltransferase activity" EXACT [EC:2.4.1.192]
xref: EC:2.4.1.192
xref: MetaCyc:2.4.1.192-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047249
name: sarsapogenin 3-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (25S)-5-beta-spirostan-3-beta-ol + UDP-D-glucose = (25S)-5-beta-spirostan-3-beta-ol 3-O-beta-D-glucoside + UDP." [EC:2.4.1.193, MetaCyc:2.4.1.193-RXN]
synonym: "sarsapogenin 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.193]
synonym: "UDP-glucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.193]
synonym: "UDPglucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.193]
synonym: "uridine diphosphoglucose-sarsapogenin glucosyltransferase activity" EXACT [EC:2.4.1.193]
xref: EC:2.4.1.193
xref: MetaCyc:2.4.1.193-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047250
name: 4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: p-hydroxybenzoate + UDP-D-glucose = 4-(beta-D-glucosyloxy)benzoate + UDP." [EC:2.4.1.194, MetaCyc:2.4.1.194-RXN]
synonym: "HBA glucosyltransferase activity" EXACT [EC:2.4.1.194]
synonym: "p-hydroxybenzoate glucosyltransferase activity" EXACT [EC:2.4.1.194]
synonym: "PHB glucosyltransferase activity" EXACT [EC:2.4.1.194]
synonym: "PHB-O-glucosyltransferase activity" EXACT [EC:2.4.1.194]
synonym: "UDP-glucose:4-(beta-D-glucopyranosyloxy)benzoic acid glucosyltransferase activity" EXACT [EC:2.4.1.194]
synonym: "UDP-glucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.194]
synonym: "UDPglucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.194]
synonym: "uridine diphosphoglucose-4-hydroxybenzoate glucosyltransferase activity" EXACT [EC:2.4.1.194]
xref: EC:2.4.1.194
xref: MetaCyc:2.4.1.194-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047251
name: thiohydroximate beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylthioacetohydroximate + UDP-D-glucose = desulfoglucotropeolin + UDP." [EC:2.4.1.195, MetaCyc:2.4.1.195-RXN]
synonym: "desulfoglucosinolate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.195]
synonym: "N-hydroxythioamide S-beta-glucosyltransferase activity" EXACT [EC:2.4.1.195]
synonym: "thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195]
synonym: "thiohydroximate S-glucosyltransferase activity" EXACT [EC:2.4.1.195]
synonym: "UDP-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.195]
synonym: "UDP-glucose:thiohydroximate S-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.195]
synonym: "UDPG:thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195]
synonym: "uridine diphosphoglucose-thiohydroximate glucosyltransferase activity" EXACT [EC:2.4.1.195]
xref: EC:2.4.1.195
xref: MetaCyc:2.4.1.195-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047252
name: beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,6-alpha-D-mannosyloligodaccharide + beta-D-mannosylphosphodecaprenol = 1,6-alpha-D-mannosyl-1,6-alpha-D-mannosyl-oligosaccharide + decaprenol phosphate." [EC:2.4.1.199, MetaCyc:2.4.1.199-RXN]
synonym: "beta-D-mannosylphosphodecaprenol:1,6-alpha-D-mannosyloligosaccharide 1,6-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.199]
synonym: "mannosylphospholipid-methylmannoside alpha-1,6-mannosyltransferase activity" EXACT [EC:2.4.1.199]
xref: EC:2.4.1.199
xref: MetaCyc:2.4.1.199-RXN
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0047253
name: alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP." [EC:2.4.1.201, MetaCyc:2.4.1.201-RXN]
synonym: "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyl-transferase activity" EXACT []
synonym: "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.201]
synonym: "N-acetylglucosaminyltransferase VI activity" RELATED [EC:2.4.1.201]
synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI activity" EXACT [EC:2.4.1.201]
synonym: "UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.201]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI" RELATED [EC:2.4.1.201]
synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI activity" EXACT [EC:2.4.1.201]
xref: EC:2.4.1.201
xref: MetaCyc:2.4.1.201-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047254
name: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one + UDP-D-glucose = 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside + UDP." [EC:2.4.1.202, MetaCyc:2.4.1.202-RXN]
synonym: "UDP-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" EXACT [EC:2.4.1.202]
synonym: "UDPglucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" EXACT [EC:2.4.1.202]
synonym: "uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase activity" EXACT [EC:2.4.1.202]
xref: EC:2.4.1.202
xref: MetaCyc:2.4.1.202-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047255
name: galactogen 6-beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP." [EC:2.4.1.205, MetaCyc:2.4.1.205-RXN]
synonym: "1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205]
synonym: "beta-(1-6)-D-galactosyltransferase activity" EXACT [EC:2.4.1.205]
synonym: "galactogen 6beta-galactosyltransferase activity" EXACT [EC:2.4.1.205]
synonym: "UDP-galactose:galactogen beta-1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205]
synonym: "UDPgalactose:galactogen beta-1,6-D-galactosyltransferase activity" EXACT [EC:2.4.1.205]
synonym: "uridine diphosphogalactose-galactogen galactosyltransferase activity" EXACT [EC:2.4.1.205]
xref: EC:2.4.1.205
xref: MetaCyc:2.4.1.205-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047256
name: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP." [EC:2.4.1.206, MetaCyc:2.4.1.206-RXN]
synonym: "beta1->3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206]
synonym: "LA2 synthase activity" EXACT [EC:2.4.1.206]
synonym: "lactosylceramide beta-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206]
synonym: "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206]
synonym: "uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.206]
xref: EC:2.4.1.206
xref: MetaCyc:2.4.1.206-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047257
name: diglucosyl diacylglycerol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-D-glucose = UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1,2)-O-alpha-D-glucopyranosyl)sn-glycerol." [EC:2.4.1.208, MetaCyc:2.4.1.208-RXN]
synonym: "DGlcDAG synthase activity" EXACT [EC:2.4.1.208]
synonym: "diglucosyl diacylglycerol (DGlcDAG) synthase activity" EXACT []
synonym: "MGlcDAG (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208]
synonym: "monoglucosyl diacylglycerol (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208]
synonym: "UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase activity" EXACT [EC:2.4.1.208]
xref: EC:2.4.1.208
xref: MetaCyc:2.4.1.208-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047258
name: sphingosine beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sphingosine + UDP-galactose = psychosine + UDP." [EC:2.4.1.23, MetaCyc:2.4.1.23-RXN]
synonym: "galactosyl-sphingosine transferase activity" EXACT [EC:2.4.1.23]
synonym: "psychosine-UDP galactosyltransferase activity" EXACT [EC:2.4.1.23]
synonym: "psychosine-uridine diphosphate galactosyltransferase activity" EXACT [EC:2.4.1.23]
synonym: "UDP-galactose:sphingosine 1-beta-galactotransferase activity" EXACT [EC:2.4.1.23]
synonym: "UDPgalactose:sphingosine 1-beta-galactotransferase activity" EXACT [EC:2.4.1.23]
synonym: "UDPgalactose:sphingosine O-galactosyl transferase activity" EXACT [EC:2.4.1.23]
synonym: "uridine diphosphogalactose-sphingosine beta-galactosyltransferase activity" EXACT [EC:2.4.1.23]
xref: EC:2.4.1.23
xref: MetaCyc:2.4.1.23-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047259
name: glucomannan 4-beta-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucomannan(n) + GDP-mannose = glucomannan(n+1) + GDP." [EC:2.4.1.32, MetaCyc:2.4.1.32-RXN]
synonym: "GDP-man-beta-mannan manosyltransferase activity" EXACT [EC:2.4.1.32]
synonym: "GDP-mannose:glucomannan 1,4-beta-D-mannosyltransferase activity" EXACT []
synonym: "glucomannan 4-b-mannosyltransferase activity" EXACT []
synonym: "glucomannan-synthase activity" EXACT []
xref: EC:2.4.1.32
xref: MetaCyc:2.4.1.32-RXN
is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity

[Term]
id: GO:0047260
name: alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP." [EC:2.4.1.36, MetaCyc:2.4.1.36-RXN]
synonym: "GDP-glucose-glucosephosphate glucosyltransferase activity" EXACT [EC:2.4.1.36]
synonym: "GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.36]
synonym: "GDPglucose-glucose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.36]
synonym: "GDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.36]
synonym: "guanosine diphosphoglucose-glucose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.36]
synonym: "trehalose phosphate synthase (GDP-forming) activity" EXACT [EC:2.4.1.36]
xref: EC:2.4.1.36
xref: MetaCyc:2.4.1.36-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047261
name: steroid N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: estradiol-17-alpha 3-D-glucuronoside + UDP-N-acetyl-D-glucosamine = 17-alpha-(N-acetyl-D-glucosaminyl)estradiol 3-D-glucuronoside + UDP." [EC:2.4.1.39, MetaCyc:2.4.1.39-RXN]
synonym: "hydroxy steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39]
synonym: "steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39]
synonym: "UDP-N-acetyl-D-glucosamine:estradiol-17alpha-3-D-glucuronoside 17alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39]
synonym: "uridine diphosphoacetylglucosamine-steroid acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.39]
xref: EC:2.4.1.39
xref: MetaCyc:2.4.1.39-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047262
name: polygalacturonate 4-alpha-galacturonosyltransferase activity
namespace: molecular_function
alt_id: GO:0050375
def: "Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP." [EC:2.4.1.43, MetaCyc:2.4.1.43-RXN]
synonym: "UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase activity" EXACT [EC:2.4.1.43]
synonym: "UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase activity" EXACT [EC:2.4.1.43]
synonym: "uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase activity" EXACT [EC:2.4.1.43]
xref: EC:2.4.1.43
xref: MetaCyc:2.4.1.43-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047263
name: N-acylsphingosine galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP." [EC:2.4.1.47, MetaCyc:2.4.1.47-RXN]
synonym: "UDP galactose-N-acylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.47]
synonym: "UDP-galactose:N-acylsphingosine D-galactosyltransferase activity" EXACT [EC:2.4.1.47]
synonym: "UDPgalactose:N-acylsphingosine D-galactosyltransferase activity" EXACT [EC:2.4.1.47]
synonym: "uridine diphosphogalactose-acylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.47]
xref: EC:2.4.1.47
xref: MetaCyc:2.4.1.47-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047264
name: heteroglycan alpha-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: heteroglycan + GDP-mannose = 1,2(or 1,3)-alpha-D-mannosylheteroglycan + GDP." [EC:2.4.1.48, MetaCyc:2.4.1.48-RXN]
synonym: "GDP mannose alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48]
synonym: "GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.48]
synonym: "guanosine diphosphomannose-heteroglycan alpha-mannosyltransferase activity" EXACT [EC:2.4.1.48]
xref: EC:2.4.1.48
xref: MetaCyc:2.4.1.48-RXN
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0047265
name: poly(glycerol-phosphate) alpha-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: poly(glycerol phosphate) + UDP-D-glucose = alpha-D-glucosylpoly(glycerol phosphate) + UDP." [EC:2.4.1.52, MetaCyc:2.4.1.52-RXN]
subset: gosubset_prok
synonym: "UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" EXACT [EC:2.4.1.52]
synonym: "UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.52]
synonym: "UDPglucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.52]
synonym: "uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" EXACT [EC:2.4.1.52]
xref: EC:2.4.1.52
xref: MetaCyc:2.4.1.52-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047266
name: poly(ribitol-phosphate) beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: poly(ribitol phosphate) + UDP-D-glucose = beta-D-glucosylpoly(ribitol phosphate) + UDP." [EC:2.4.1.53, MetaCyc:2.4.1.53-RXN]
synonym: "UDP glucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" EXACT [EC:2.4.1.53]
synonym: "UDP-D-glucose polyribitol phosphate glucosyl transferase activity" EXACT [EC:2.4.1.53]
synonym: "UDP-D-glucose:polyribitol phosphate glucosyl transferase activity" EXACT [EC:2.4.1.53]
synonym: "UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.53]
synonym: "UDPglucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.53]
synonym: "uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" EXACT [EC:2.4.1.53]
xref: EC:2.4.1.53
xref: MetaCyc:2.4.1.53-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047267
name: undecaprenyl-phosphate mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: undecaprenyl phosphate + GDP-mannose = D-mannosyl-1-phosphoundecaprenol + GDP." [EC:2.4.1.54, MetaCyc:2.4.1.54-RXN]
synonym: "GDP mannose-undecaprenyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.54]
synonym: "GDP-D-mannose:lipid phosphate transmannosylase activity" EXACT [EC:2.4.1.54]
synonym: "GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase activity" EXACT [EC:2.4.1.54]
synonym: "guanosine diphosphomannose-undecaprenyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.54]
xref: EC:2.4.1.54
xref: MetaCyc:2.4.1.54-RXN
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0047268
name: galactinol-raffinose galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol." [EC:2.4.1.67, MetaCyc:2.4.1.67-RXN]
synonym: "alpha-D-(1->3)-galactosyl-myo-inositol:raffinose galactosyltransferase activity" EXACT [EC:2.4.1.67]
synonym: "stachyose synthetase activity" EXACT [EC:2.4.1.67]
xref: EC:2.4.1.67
xref: MetaCyc:2.4.1.67-RXN
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0047269
name: poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: poly(ribitol phosphate) + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-poly(ribitol phosphate) + UDP." [EC:2.4.1.70, MetaCyc:2.4.1.70-RXN]
synonym: "UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.70]
synonym: "UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.70]
synonym: "uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.70]
xref: EC:2.4.1.70
xref: MetaCyc:2.4.1.70-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0047270
name: lipopolysaccharide glucosyltransferase II activity
namespace: molecular_function
def: "Catalysis of the reaction: lipopolysaccharide + UDP-D-glucose = D-glucosyl-lipopolysaccharide + UDP." [EC:2.4.1.73, MetaCyc:2.4.1.73-RXN]
synonym: "LPS glucosyltransferase II activity" EXACT []
synonym: "UDP-glucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.73]
synonym: "UDPglucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.73]
synonym: "uridine diphosphoglucose-galactosylpolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.73]
xref: EC:2.4.1.73
xref: MetaCyc:2.4.1.73-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047271
name: glycosaminoglycan galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycosaminoglycan + UDP-galactose = D-galactosylglycosaminoglycan + UDP." [EC:2.4.1.74, MetaCyc:2.4.1.74-RXN]
synonym: "UDP-galactose:glycosaminoglycan D-galactosyltransferase activity" EXACT [EC:2.4.1.74]
synonym: "UDPgalactose:glycosaminoglycan D-galactosyltransferase activity" EXACT [EC:2.4.1.74]
synonym: "uridine diphosphogalactose-mucopolysaccharide galactosyltransferase activity" EXACT [EC:2.4.1.74]
xref: EC:2.4.1.74
xref: MetaCyc:2.4.1.74-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047272
name: phosphopolyprenol glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP." [EC:2.4.1.78, MetaCyc:2.4.1.78-RXN]
synonym: "UDP-glucose:phosphopolyprenol D-glucosyltransferase activity" EXACT [EC:2.4.1.78]
synonym: "UDPglucose:phosphopolyprenol D-glucosyltransferase activity" EXACT [EC:2.4.1.78]
synonym: "UDPglucose:polyprenol monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.78]
synonym: "uridine diphosphoglucose-polyprenol monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.78]
xref: EC:2.4.1.78
xref: MetaCyc:2.4.1.78-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047273
name: galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity
namespace: molecular_function
alt_id: GO:0047226
def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide." [EC:2.4.1.79, MetaCyc:2.4.1.79-RXN]
synonym: "beta-3GalNAc-T1 activity" EXACT [EC:2.4.1.79]
synonym: "beta3GalNAc-T1" RELATED [EC:2.4.1.79]
synonym: "galactosylgalactosylglucosylceramide beta-D- activity" EXACT [EC:2.4.1.79]
synonym: "globoside synthase activity" EXACT [EC:2.4.1.79]
synonym: "globoside synthetase activity" EXACT [EC:2.4.1.79]
synonym: "globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79]
synonym: "globotriosylceramide beta-1,6-N-acetylgalactosaminyltransferase activity" EXACT []
synonym: "UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.79]
synonym: "UDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.79]
synonym: "UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79]
synonym: "UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79]
synonym: "uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.79]
xref: EC:2.4.1.79
xref: MetaCyc:2.4.1.79-RXN
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0047274
name: galactinol-sucrose galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + 1-alpha-D-galactosyl-myo-inositol = raffinose + myo-inositol." [EC:2.4.1.82, MetaCyc:2.4.1.82-RXN]
synonym: "1-alpha-D-galactosyl-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.82]
synonym: "alpha-D-galactosyl-(1->3)-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.82]
synonym: "galactinol:sucrose 6-galactosyl transferase activity" EXACT []
synonym: "galactosyltransferase, galactinol-sucrose" EXACT []
synonym: "raffinose synthase activity" EXACT []
xref: EC:2.4.1.82
xref: MetaCyc:2.4.1.82-RXN
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0047275
name: glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = D-galactosyl-N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.86, MetaCyc:2.4.1.86-RXN]
synonym: "GalT-4" RELATED [EC:2.4.1.86]
synonym: "paragloboside synthase activity" EXACT [EC:2.4.1.86]
synonym: "UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.86]
synonym: "UDPgalactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.86]
synonym: "uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.86]
xref: EC:2.4.1.86
xref: MetaCyc:2.4.1.86-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047276
name: N-acetyllactosaminide 3-alpha-galactosyltransferase activity
namespace: molecular_function
alt_id: GO:0003946
def: "Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP." [EC:2.4.1.87, MetaCyc:2.4.1.87-RXN]
synonym: "alpha-galactosyltransferase activity" RELATED [EC:2.4.1.87]
synonym: "beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "beta-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT []
synonym: "glucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "N-acetyllactosaminide alpha-1,3-galactosyltransferase activity" EXACT []
synonym: "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha-(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDP-Gal:Gal-beta-1->4GlcNAc-R alpha-1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDP-Gal:N-acetyllactosaminide alpha-(1,3)-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "uridine diphosphogalactose-acetyllactosamine alpha-1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "uridine diphosphogalactose-acetyllactosamine galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosyl-glucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.87]
synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase activity" EXACT [EC:2.4.1.87]
xref: EC:2.4.1.87
xref: MetaCyc:2.4.1.151-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047277
name: globoside alpha-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.88, MetaCyc:2.4.1.88-RXN]
synonym: "Forssman synthase activity" RELATED [EC:2.4.1.88]
synonym: "forssman synthase activity" EXACT [EC:2.4.1.88]
synonym: "globoside acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.88]
synonym: "UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.88]
synonym: "uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.88]
xref: EC:2.4.1.88
xref: MetaCyc:2.4.1.88-RXN
is_a: GO:0008376 ! acetylgalactosaminyltransferase activity

[Term]
id: GO:0047278
name: bilirubin-glucuronoside glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 bilirubin-glucuronoside = bilirubin-bisglucuronoside + bilirubin." [EC:2.4.1.95, MetaCyc:2.4.1.95-RXN]
synonym: "bilirubin glucuronoside glucuronosyltransferase activity" EXACT [EC:2.4.1.95]
synonym: "bilirubin monoglucuronide transglucuronidase activity" EXACT [EC:2.4.1.95]
synonym: "bilirubin-glucuronoside:bilirubin-glucuronoside D-glucuronosyltransferase activity" EXACT [EC:2.4.1.95]
xref: EC:2.4.1.95
xref: MetaCyc:2.4.1.95-RXN
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0047279
name: sn-glycerol-3-phosphate 1-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol-3-phosphate + UDP-galactose = alpha-D-galactosyl-(1,1')-sn-glycerol 3-phosphate + UDP." [EC:2.4.1.96, MetaCyc:2.4.1.96-RXN]
synonym: "glycerol 3-phosphate 1alpha-galactosyltransferase activity" EXACT [EC:2.4.1.96]
synonym: "isofloridoside-phosphate synthase activity" EXACT [EC:2.4.1.96]
synonym: "UDP-Gal:sn-glycero-3-phosphoric acid 1-alpha-galactosyl-transferase activity" EXACT [EC:2.4.1.96]
synonym: "UDP-galactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96]
synonym: "UDPgalactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96]
synonym: "UDPgalactose:sn-glycerol-3-phosphate alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.96]
synonym: "uridine diphosphogalactose-glycerol phosphate galactosyltransferase activity" EXACT [EC:2.4.1.96]
xref: EC:2.4.1.96
xref: MetaCyc:2.4.1.96-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047280
name: nicotinamide phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyrophosphate + nicotinamide nucleotide = PRPP + niacinamide." [EC:2.4.2.12, MetaCyc:2.4.2.12-RXN]
synonym: "nicotinamide mononucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.12]
synonym: "nicotinamide mononucleotide synthetase activity" EXACT [EC:2.4.2.12]
synonym: "nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.12]
synonym: "NMN diphosphorylase activity" EXACT [EC:2.4.2.12]
synonym: "NMN pyrophosphorylase activity" EXACT [EC:2.4.2.12]
synonym: "NMN synthetase activity" EXACT [EC:2.4.2.12]
xref: EC:2.4.2.12
xref: MetaCyc:2.4.2.12-RXN
xref: Reactome:83046 "nicotinamide phosphoribosyltransferase activity"
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0047281
name: dioxotetrahydropyrimidine phosphoribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyrophosphate + a 2,4-dioxotetrahydropyrimidine D-ribonucleotide = PRPP + a 2,4-dioxotetrahydropyrimidine." [EC:2.4.2.20, MetaCyc:2.4.2.20-RXN]
synonym: "2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.20]
synonym: "dioxotetrahydropyrimidine phosphoribosyl transferase activity" EXACT [EC:2.4.2.20]
synonym: "dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.20]
synonym: "dioxotetrahydropyrimidine-ribonucleotide diphosphorylase activity" EXACT [EC:2.4.2.20]
synonym: "dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.20]
xref: EC:2.4.2.20
xref: MetaCyc:2.4.2.20-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0047282
name: dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: streptidine 6-phosphate + dTDP-L-dihydrostreptose = O-1,4-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP." [EC:2.4.2.27, MetaCyc:2.4.2.27-RXN]
subset: gosubset_prok
synonym: "dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27]
synonym: "dTDPdihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27]
synonym: "thymidine diphosphodihydrostreptose-streptidine 6-phosphate dihydrostreptosyltransferase activity" EXACT [EC:2.4.2.27]
xref: EC:2.4.2.27
xref: MetaCyc:2.4.2.27-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0047283
name: dolichyl-phosphate D-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichol-phosphate + UDP-D-xylose = dolichyl D-xylosyl phosphate + UDP." [EC:2.4.2.32, MetaCyc:2.4.2.32-RXN]
synonym: "UDP-D-xylose:dolichyl-phosphate D-xylosyltransferase activity" EXACT [EC:2.4.2.32]
xref: EC:2.4.2.32
xref: MetaCyc:2.4.2.32-RXN
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0047284
name: dolichyl-xylosyl-phosphate-protein xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolichol-phosphate + D-xylosylprotein." [EC:2.4.2.33, MetaCyc:2.4.2.33-RXN]
synonym: "dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase activity" EXACT [EC:2.4.2.33]
xref: EC:2.4.2.33
xref: MetaCyc:2.4.2.33-RXN
is_a: GO:0042285 ! xylosyltransferase activity

[Term]
id: GO:0047285
name: flavonol-3-O-glycoside xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP." [EC:2.4.2.35, MetaCyc:2.4.2.35-RXN]
synonym: "UDP-D-xylose:flavonol-3-O-glycoside 2''-O-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.35]
xref: EC:2.4.2.35
xref: MetaCyc:2.4.2.35-RXN
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0047286
name: NAD+-diphthamide ADP-ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide." [EC:2.4.2.36, MetaCyc:2.4.2.36-RXN]
subset: gosubset_prok
synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.36]
synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.36]
synonym: "NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase activity" EXACT [EC:2.4.2.36]
synonym: "NAD-diphthamide ADP-ribosyltransferase activity" EXACT []
xref: EC:2.4.2.36
xref: MetaCyc:2.4.2.36-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0047287
name: lactosylceramide alpha-2,6-N-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,6-beta-galactosyl-1,4-beta-D-glucosylceramide + CMP." [EC:2.4.99.11, MetaCyc:2.4.99.11-RXN]
synonym: "CMP-acetylneuraminate-lactosylceramide-sialyltransferase" BROAD [EC:2.4.99.11]
synonym: "CMP-N-acetylneuraminate:lactosylceramide alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.11]
synonym: "CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.11]
synonym: "CMP-sialic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.11]
synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase" BROAD [EC:2.4.99.11]
xref: EC:2.4.99.11
xref: MetaCyc:2.4.99.11-RXN
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0047288
name: monosialoganglioside sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP-N-acetylneuraminate = N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP." [EC:2.4.99.2, MetaCyc:2.4.99.2-RXN]
synonym: "CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.2]
xref: EC:2.4.99.2
xref: MetaCyc:2.4.99.2-RXN
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0047289
name: galactosyldiacylglycerol alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + CMP-N-acetylneuraminate = 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP." [EC:2.4.99.5, MetaCyc:2.4.99.5-RXN]
synonym: "CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.5]
xref: EC:2.4.99.5
xref: MetaCyc:2.4.99.5-RXN
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0047290
name: (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(alpha-N-acetylneuraminyl-2,6)-N-acetyl-D-galactosaminyl-R + CMP." [EC:2.4.99.7, MetaCyc:2.4.99.7-RXN]
synonym: "(alpha-N-acetylneuraminyl-2,3-alpha-galactosyl-1,3)-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7]
synonym: "(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity" EXACT []
synonym: "alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7]
synonym: "CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase activity" EXACT [EC:2.4.99.7]
synonym: "cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7]
synonym: "NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7]
synonym: "neuac-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.7]
synonym: "sialyltransferase 3C activity" RELATED [EC:2.4.99.7]
synonym: "sialyltransferase 7D activity" RELATED [EC:2.4.99.7]
synonym: "SIAT7" RELATED [EC:2.4.99.7]
synonym: "ST6GALNAC activity" EXACT [EC:2.4.99.7]
xref: EC:2.4.99.7
xref: MetaCyc:2.4.99.7-RXN
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0047291
name: lactosylceramide alpha-2,3-sialyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3." [EC:2.4.99.9, MetaCyc:2.4.99.9-RXN]
synonym: "CMP-acetylneuraminate-lactosylceramide-sialyltransferase" BROAD [EC:2.4.99.9]
synonym: "CMP-acetylneuraminic acid:lactosylceramide sialyltransferase activity" EXACT [EC:2.4.99.9]
synonym: "CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.9]
synonym: "CMP-sialic acid:lactosylceramide-sialyltransferase activity" EXACT [EC:2.4.99.9]
synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase activity" EXACT [EC:2.4.99.9]
synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase" BROAD [EC:2.4.99.9]
synonym: "ganglioside GM3 synthase activity" EXACT [EC:2.4.99.9]
synonym: "ganglioside GM3 synthetase activity" EXACT [EC:2.4.99.9]
synonym: "GM3 synthase activity" EXACT [EC:2.4.99.9]
synonym: "GM3 synthetase activity" EXACT [EC:2.4.99.9]
synonym: "SAT 1" RELATED [EC:2.4.99.9]
xref: EC:2.4.99.9
xref: MetaCyc:2.4.99.9-RXN
is_a: GO:0008373 ! sialyltransferase activity

[Term]
id: GO:0047292
name: trihydroxypterocarpan dimethylallyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6AS,11AS)-3,6A,9-trihydroxypterocarpan + dimethylallyl-pyrophosphate = glyceollin + pyrophosphate." [EC:2.5.1.36, MetaCyc:2.5.1.36-RXN]
synonym: "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity" EXACT [EC:2.5.1.36]
synonym: "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethyltransferase activity" EXACT [EC:2.5.1.36]
synonym: "dimethylallylpyrophosphate:3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity" EXACT [EC:2.5.1.36]
synonym: "dimethylallylpyrophosphate:trihydroxypterocarpan dimethylallyl transferase activity" EXACT [EC:2.5.1.36]
xref: EC:2.5.1.36
xref: MetaCyc:2.5.1.36-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047293
name: 4-hydroxybenzoate nonaprenyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + pyrophosphate." [EC:2.5.1.39, MetaCyc:2.5.1.39-RXN]
synonym: "4-hydroxybenzoate transferase activity" EXACT [EC:2.5.1.39]
synonym: "nonaprenyl-4-hydroxybenzoate transferase activity" EXACT [EC:2.5.1.39]
synonym: "p-hydroxybenzoate dimethylallyltransferase activity" EXACT [EC:2.5.1.39]
synonym: "p-hydroxybenzoate polyprenyltransferase activity" EXACT [EC:2.5.1.39]
synonym: "p-hydroxybenzoic acid-polyprenyl transferase activity" EXACT [EC:2.5.1.39]
synonym: "p-hydroxybenzoic-polyprenyl transferase activity" EXACT [EC:2.5.1.39]
synonym: "solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase activity" EXACT [EC:2.5.1.39]
xref: EC:2.5.1.39
xref: MetaCyc:2.5.1.39-RXN
is_a: GO:0002094 ! polyprenyltransferase activity

[Term]
id: GO:0047294
name: phosphoglycerol geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glyceryl phosphate + geranylgeranyl-PP = sn-3-O-(geranylgeranyl)glyceryl 1-phosphate + diphosphate." [EC:2.5.1.41, MetaCyc:2.5.1.41-RXN]
synonym: "geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.41]
synonym: "geranylgeranyl-transferase activity" EXACT [EC:2.5.1.41]
synonym: "glycerol phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.41]
xref: EC:2.5.1.41
xref: MetaCyc:2.5.1.41-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047295
name: geranylgeranylglycerol-phosphate geranylgeranyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-3-O-(geranylgeranyl)glycerol 1-phosphate + geranylgeranyl-PP = 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate." [EC:2.5.1.42, MetaCyc:2.5.1.42-RXN]
synonym: "geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.42]
synonym: "geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.42]
synonym: "geranylgeranyltransferase II" RELATED [EC:2.5.1.42]
xref: EC:2.5.1.42
xref: MetaCyc:2.5.1.42-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047296
name: homospermidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine." [EC:2.5.1.44, MetaCyc:2.5.1.44-RXN]
subset: gosubset_prok
synonym: "putrescine:putrescine 4-aminobutyltransferase (ammonia-forming)" EXACT [EC:2.5.1.44]
xref: EC:2.5.1.44
xref: MetaCyc:2.5.1.44-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047297
name: asparagine-oxo-acid transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate." [EC:2.6.1.14, MetaCyc:2.6.1.14-RXN]
synonym: "asparagine--oxo-acid aminotransferase activity" EXACT [EC:2.6.1.14]
synonym: "asparagine-keto acid aminotransferase activity" EXACT [EC:2.6.1.14]
synonym: "asparagine-oxo-acid aminotransferase activity" EXACT []
synonym: "L-asparagine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.14]
xref: EC:2.6.1.14
xref: MetaCyc:2.6.1.14-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047298
name: (S)-3-amino-2-methylpropionate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + (S)-3-amino-2-methylpropanoate = L-glutamate + methylmalonate-semialdehyde." [EC:2.6.1.22, MetaCyc:2.6.1.22-RXN]
subset: gosubset_prok
synonym: "(S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.22]
synonym: "(S)-3-amino-2-methylpropionate aminotransferase activity" EXACT []
synonym: "beta-aminobutyric transaminase activity" EXACT [EC:2.6.1.22]
synonym: "beta-aminoisobutyrate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.22]
synonym: "L-3-aminoisobutyrate aminotransferase activity" EXACT [EC:2.6.1.22]
synonym: "L-3-aminoisobutyrate transaminase activity" EXACT [EC:2.6.1.22]
synonym: "L-3-aminoisobutyric aminotransferase activity" EXACT [EC:2.6.1.22]
synonym: "L-AIBAT activity" EXACT [EC:2.6.1.22]
xref: EC:2.6.1.22
xref: MetaCyc:2.6.1.22-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047299
name: tryptophan-phenylpyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylpyruvate + L-tryptophan = L-phenylalanine + indolepyruvate." [EC:2.6.1.28, MetaCyc:2.6.1.28-RXN]
synonym: "L-tryptophan-alpha-ketoisocaproate aminotransferase activity" EXACT [EC:2.6.1.28]
synonym: "L-tryptophan:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.28]
synonym: "tryptophan--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.28]
synonym: "tryptophan-phenylpyruvate aminotransferase activity" EXACT []
xref: EC:2.6.1.28
xref: MetaCyc:2.6.1.28-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047300
name: pyridoxamine-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + pyridoxamine = L-alanine + pyridoxal." [EC:2.6.1.30, MetaCyc:2.6.1.30-RXN]
synonym: "pyridoxamine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.30]
synonym: "pyridoxamine-pyruvate aminotransferase activity" EXACT []
synonym: "pyridoxamine-pyruvic transaminase" BROAD [EC:2.6.1.30]
synonym: "pyridoxamine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.30]
synonym: "pyridoxamineu-pyruvic transaminase activity" EXACT [EC:2.6.1.30]
xref: EC:2.6.1.30
xref: MetaCyc:2.6.1.30-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047301
name: valine-3-methyl-2-oxovalerate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-keto-3-methyl-valerate + L-valine = L-iso-leucine + 2-keto-isovalerate." [EC:2.6.1.32, MetaCyc:2.6.1.32-RXN]
synonym: "L-valine:(S)-3-methyl-2-oxopentanoate aminotransferase activity" EXACT [EC:2.6.1.32]
synonym: "valine--3-methyl-2-oxovalerate aminotransferase activity" EXACT [EC:2.6.1.32]
synonym: "valine--isoleucine aminotransferase activity" EXACT [EC:2.6.1.32]
synonym: "valine--isoleucine transaminase activity" EXACT [EC:2.6.1.32]
synonym: "valine-2-keto-methylvalerate aminotransferase activity" EXACT [EC:2.6.1.32]
synonym: "valine-3-methyl-2-oxovalerate aminotransferase activity" EXACT []
xref: EC:2.6.1.32
xref: MetaCyc:2.6.1.32-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047302
name: UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose." [EC:2.6.1.34, MetaCyc:2.6.1.34-RXN]
synonym: "UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.34]
synonym: "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity" EXACT []
synonym: "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose transaminase activity" EXACT []
synonym: "uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity" EXACT [EC:2.6.1.34]
xref: EC:2.6.1.34
xref: MetaCyc:2.6.1.34-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047303
name: glycine-oxaloacetate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxaloacetic acid + L-glycine = L-aspartate + glyoxylate." [EC:2.6.1.35, MetaCyc:2.6.1.35-RXN]
synonym: "glycine--oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.35]
synonym: "glycine-oxalacetate aminotransferase activity" EXACT [EC:2.6.1.35]
synonym: "glycine-oxaloacetate aminotransferase activity" EXACT []
synonym: "glycine:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.35]
xref: EC:2.6.1.35
xref: MetaCyc:2.6.1.35-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047304
name: 2-aminoethylphosphonate-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + (2-aminoethyl)phosphonate = L-alanine + phosphonoacetaldehyde." [EC:2.6.1.37, MetaCyc:2.6.1.37-RXN]
subset: gosubset_prok
synonym: "(2-aminoethyl)phosphonate aminotransferase activity" EXACT [EC:2.6.1.37]
synonym: "(2-aminoethyl)phosphonate transaminase activity" EXACT [EC:2.6.1.37]
synonym: "(2-aminoethyl)phosphonate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.37]
synonym: "(2-aminoethyl)phosphonate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.37]
synonym: "(2-aminoethyl)phosphonic acid aminotransferase activity" EXACT [EC:2.6.1.37]
synonym: "2-aminoethylphosphonate aminotransferase activity" EXACT [EC:2.6.1.37]
synonym: "2-aminoethylphosphonate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.37]
synonym: "2-aminoethylphosphonate-pyruvate aminotransferase activity" EXACT []
xref: EC:2.6.1.37
xref: MetaCyc:2.6.1.37-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047305
name: (R)-3-amino-2-methylpropionate-pyruvate transaminase activity
namespace: molecular_function
alt_id: GO:0047314
def: "Catalysis of the reaction: pyruvate + (R)-3-amino-2-methylpropanoate = L-alanine + methylmalonate-semialdehyde." [EC:2.6.1.40, MetaCyc:2.6.1.40-RXN]
comment: Note that this function was EC:2.6.1.61.
synonym: "(R)-3-amino-2-methylpropanoate aminotransferase activity" EXACT []
synonym: "(R)-3-amino-2-methylpropanoate transaminase activity" EXACT []
synonym: "(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.40]
synonym: "(R)-3-amino-2-methylpropionate transaminase activity" EXACT []
synonym: "(R)-3-amino-2-methylpropionate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.40]
synonym: "(R)-3-amino-2-methylpropionate-pyruvate aminotransferase activity" EXACT []
synonym: "beta-aminoisobutyrate--pyruvate transaminase activity" EXACT [EC:2.6.1.40]
synonym: "beta-aminoisobutyrate-pyruvate aminotransferase activity" EXACT [EC:2.6.1.40]
synonym: "D-3-aminoisobutyrate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.40]
synonym: "D-3-aminoisobutyrate--pyruvate transaminase activity" EXACT [EC:2.6.1.40]
synonym: "D-3-aminoisobutyrate-pyruvate transaminase activity" EXACT [EC:2.6.1.40]
synonym: "D-AIBAT activity" EXACT [EC:2.6.1.40]
synonym: "D-beta-aminoisobutyrate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.40]
xref: EC:2.6.1.40
xref: MetaCyc:2.6.1.40-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047306
name: D-methionine-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + D-methionine = L-alanine + 2-keto-4-methylthiobutyrate." [EC:2.6.1.41, MetaCyc:2.6.1.41-RXN]
synonym: "D-methionine aminotransferase activity" EXACT [EC:2.6.1.41]
synonym: "D-methionine transaminase activity" EXACT [EC:2.6.1.41]
synonym: "D-methionine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.41]
synonym: "D-methionine-pyruvate aminotransferase activity" EXACT []
synonym: "D-methionine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.41]
xref: EC:2.6.1.41
xref: MetaCyc:2.6.1.41-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047307
name: diaminobutyrate-pyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + L-2,4-diaminobutanoate = L-aspartate-semialdehyde + L-alanine." [EC:2.6.1.46, MetaCyc:2.6.1.46-RXN]
subset: gosubset_prok
synonym: "diaminobutyrate--pyruvate aminotransferase activity" EXACT [EC:2.6.1.46]
synonym: "diaminobutyrate-pyruvate aminotransferase activity" EXACT []
synonym: "L-2,4-diaminobutanoate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.46]
synonym: "L-diaminobutyric acid transaminase activity" EXACT [EC:2.6.1.46]
xref: EC:2.6.1.46
xref: MetaCyc:2.6.1.46-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047308
name: alanine-oxomalonate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxomalonate + L-alanine = aminomalonate + pyruvate." [EC:2.6.1.47, MetaCyc:2.6.1.47-RXN]
synonym: "alanine--oxomalonate aminotransferase activity" EXACT [EC:2.6.1.47]
synonym: "alanine-ketomalonate (mesoxalate) transaminase activity" EXACT [EC:2.6.1.47]
synonym: "alanine-oxomalonate aminotransferase activity" EXACT []
synonym: "L-alanine-ketomalonate transaminase activity" EXACT [EC:2.6.1.47]
synonym: "L-alanine:oxomalonate aminotransferase activity" EXACT [EC:2.6.1.47]
xref: EC:2.6.1.47
xref: MetaCyc:2.6.1.47-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047309
name: dihydroxyphenylalanine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-dihydroxy-phenylalanine = L-glutamate + 3,4-dihydroxyphenylpyruvate." [EC:2.6.1.49, MetaCyc:2.6.1.49-RXN]
synonym: "3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.49]
synonym: "aspartate-DOPP transaminase (ADT)" EXACT [EC:2.6.1.49]
synonym: "dihydroxyphenylalanine aminotransferase activity" EXACT []
synonym: "dopa aminotransferase activity" EXACT [EC:2.6.1.49]
synonym: "DOPA aminotransferase activity" EXACT [EC:2.6.1.49]
synonym: "dopa transaminase activity" EXACT [EC:2.6.1.49]
synonym: "glutamate-DOPP transaminase (GDT)" EXACT [EC:2.6.1.49]
synonym: "L-dopa transaminase activity" EXACT [EC:2.6.1.49]
synonym: "phenylalanine-DOPP transaminase (PDT)" EXACT [EC:2.6.1.49]
xref: EC:2.6.1.49
xref: MetaCyc:2.6.1.49-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047310
name: glutamine-scyllo-inositol transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-keto-myo-inositol + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-keto-glutaramate." [EC:2.6.1.50, MetaCyc:2.6.1.50-RXN]
subset: gosubset_prok
synonym: "glutamine scyllo-inosose aminotransferase activity" EXACT [EC:2.6.1.50]
synonym: "glutamine--scyllo-inosose aminotransferase activity" EXACT [EC:2.6.1.50]
synonym: "glutamine--scyllo-inosose transaminase activity" EXACT [EC:2.6.1.50]
synonym: "glutamine-scyllo-inosose aminotransferase activity" EXACT []
synonym: "glutamine-scyllo-inosose transaminase activity" EXACT []
synonym: "L-glutamine-keto-scyllo-inositol aminotransferase activity" EXACT [EC:2.6.1.50]
synonym: "L-glutamine-scyllo-inosose transaminase activity" EXACT [EC:2.6.1.50]
synonym: "L-glutamine:2,4,6/3,5-pentahydroxycyclohexanone aminotransferase activity" EXACT [EC:2.6.1.50]
xref: EC:2.6.1.50
xref: MetaCyc:2.6.1.50-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047311
name: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol = L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol." [EC:2.6.1.56, MetaCyc:2.6.1.56-RXN]
synonym: "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol aminotransferase activity" EXACT []
synonym: "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase activity" EXACT [EC:2.6.1.56]
synonym: "guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase activity" EXACT [EC:2.6.1.56]
synonym: "L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase activity" EXACT [EC:2.6.1.56]
xref: EC:2.6.1.56
xref: MetaCyc:2.6.1.56-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047312
name: L-phenylalanine:pyruvate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine." [EC:2.6.1.58, MetaCyc:2.6.1.58-RXN]
synonym: "histidine aminotransferase activity" RELATED [GOC:kad]
synonym: "histidine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.58, GOC:kad]
synonym: "L-histidine:pyruvate aminotransferase activity" RELATED [GOC:kad]
synonym: "L-phenylalanine(L-histidine):pyruvate aminotransferase activity" BROAD [EC:2.6.1.58]
synonym: "L-phenylalanine:pyruvate transaminase activity" EXACT [GOC:kad]
synonym: "phenylalanine (histidine) aminotransferase activity" BROAD [EC:2.6.1.58]
synonym: "phenylalanine(histidine) aminotransferase activity" BROAD []
synonym: "phenylalanine(histidine) transaminase activity" BROAD [EC:2.6.1.58]
synonym: "phenylalanine(histidine):pyruvate aminotransferase activity" BROAD [EC:2.6.1.58]
xref: EC:2.6.1.58
xref: MetaCyc:2.6.1.58-RXN
is_a: GO:0070546 ! L-phenylalanine aminotransferase activity

[Term]
id: GO:0047313
name: aromatic-amino-acid-glyoxylate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid." [EC:2.6.1.60, MetaCyc:2.6.1.60-RXN]
synonym: "aromatic-amino-acid--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.60]
synonym: "aromatic-amino-acid-glyoxylate aminotransferase activity" EXACT []
synonym: "aromatic-amino-acid:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.60]
xref: EC:2.6.1.60
xref: MetaCyc:2.6.1.60-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047315
name: kynurenine-glyoxylate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxylate + kynurenine = L-glycine + 4-(2-aminophenyl)-2,4-dioxobutanoate." [EC:2.6.1.63, MetaCyc:2.6.1.63-RXN]
synonym: "kynurenine--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.63]
synonym: "kynurenine-glyoxylate aminotransferase activity" EXACT []
synonym: "L-kynurenine:glyoxylate aminotransferase (cyclizing)" EXACT [EC:2.6.1.63]
xref: EC:2.6.1.63
xref: MetaCyc:2.6.1.63-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047316
name: glutamine-phenylpyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylpyruvate + L-glutamine = L-phenylalanine + 2-keto-glutaramate." [EC:2.6.1.64, MetaCyc:2.6.1.64-RXN]
synonym: "glutamine transaminase K activity" RELATED [EC:2.6.1.64]
synonym: "glutamine--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.64]
synonym: "glutamine-phenylpyruvate aminotransferase activity" EXACT []
synonym: "L-glutamine:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.64]
xref: EC:2.6.1.64
xref: MetaCyc:2.6.1.64-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047317
name: N6-acetyl-beta-lysine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate." [EC:2.6.1.65, MetaCyc:2.6.1.65-RXN]
synonym: "6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.65]
synonym: "epsilon-acetyl-beta-lysine aminotransferase activity" EXACT [EC:2.6.1.65]
synonym: "N(6)-acetyl-beta-lysine aminotransferase activity" EXACT [EC:2.6.1.65]
synonym: "N6-acetyl-beta-lysine aminotransferase activity" EXACT []
xref: EC:2.6.1.65
xref: MetaCyc:2.6.1.65-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047319
name: aspartate-phenylpyruvate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetic acid." [EC:2.6.1.70, MetaCyc:2.6.1.70-RXN]
synonym: "aspartate--phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.70]
synonym: "aspartate-phenylpyruvate aminotransferase activity" EXACT []
synonym: "L-aspartate:phenylpyruvate aminotransferase activity" EXACT [EC:2.6.1.70]
xref: EC:2.6.1.70
xref: MetaCyc:2.6.1.70-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047320
name: D-4-hydroxyphenylglycine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = L-glutamate + 4-hydroxyphenylglyoxylate." [EC:2.6.1.72, MetaCyc:2.6.1.72-RXN]
synonym: "D-4-hydroxyphenylglycine aminotransferase activity" EXACT []
synonym: "D-4-hydroxyphenylglycine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.72]
synonym: "D-hydroxyphenylglycine aminotransferase activity" EXACT [EC:2.6.1.72]
xref: EC:2.6.1.72
xref: MetaCyc:2.6.1.72-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047321
name: diphosphate-protein phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: microsomal-membrane protein + diphosphate = pyrophosphate + O-phospho-microsomal-membrane protein." [EC:2.7.99.1, MetaCyc:2.7.99.1-RXN]
synonym: "diphosphate:microsomal-membrane-protein O-phosphotransferase activity" BROAD [EC:2.7.99.1]
synonym: "DiPPT" RELATED [EC:2.7.99.1]
synonym: "pyrophosphate-protein phosphotransferase activity" EXACT [EC:2.7.99.1]
synonym: "pyrophosphate:protein phosphotransferase activity" EXACT [EC:2.7.99.1]
synonym: "triphosphate-protein phosphotransferase activity" EXACT [EC:2.7.99.1]
synonym: "triphosphate:microsomal-membrane-protein phosphotransferase activity" EXACT [EC:2.7.99.1]
xref: EC:2.7.99.1
xref: MetaCyc:2.7.99.1-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047322
name: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP." [EC:2.7.11.31, MetaCyc:2.7.1.109-RXN]
synonym: "3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activity" EXACT [EC:2.7.11.31]
synonym: "3-hydroxy-3-methylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31]
synonym: "AMPK" RELATED [EC:2.7.11.31]
synonym: "ATP:hydroxymethylglutaryl-CoA reductase (NADPH) phosphotransferase activity" EXACT [EC:2.7.11.31]
synonym: "beta-hydroxy-beta-methylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31]
synonym: "HMG-CoA reductase kinase activity" EXACT [EC:2.7.11.31]
synonym: "hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) activity" EXACT [EC:2.7.11.31]
synonym: "hydroxymethylglutaryl coenzyme A reductase kinase activity" EXACT [EC:2.7.11.31]
synonym: "hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity" EXACT [EC:2.7.11.31]
synonym: "hydroxymethylglutaryl-CoA reductase (NADPH2) kinase activity" EXACT [EC:2.7.11.31]
synonym: "hydroxymethylglutaryl-CoA reductase kinase activity" EXACT [EC:2.7.11.31]
synonym: "reductase kinase activity" BROAD [EC:2.7.11.31]
synonym: "STK29" RELATED [EC:2.7.11.31]
xref: EC:2.7.11.31
xref: MetaCyc:2.7.1.109-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0047323
name: [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.4]
synonym: "3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase activity" EXACT [EC:2.7.11.4]
synonym: "[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase activity" EXACT []
synonym: "ATP:3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphotransferase activity" EXACT [EC:2.7.11.4]
synonym: "BCK" RELATED [EC:2.7.11.4]
synonym: "BCKD kinase activity" EXACT [EC:2.7.11.4]
synonym: "BCODH kinase activity" EXACT [EC:2.7.11.4]
synonym: "branched-chain 2-oxo acid dehydrogenase kinase activity" EXACT [EC:2.7.11.4]
synonym: "branched-chain alpha-ketoacid dehydrogenase kinase activity" EXACT [EC:2.7.11.4]
synonym: "branched-chain keto acid dehydrogenase kinase activity" EXACT [EC:2.7.11.4]
synonym: "branched-chain oxo acid dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.4]
synonym: "STK2" RELATED [EC:2.7.11.4]
xref: EC:2.7.11.4
xref: MetaCyc:2.7.11.4-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0047324
name: phosphoenolpyruvate-glycerone phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydroxy-acetone + phosphoenolpyruvate = dihydroxy-acetone-phosphate + pyruvate." [EC:2.7.1.121, MetaCyc:2.7.1.121-RXN]
synonym: "phosphoenolpyruvate:glycerone phosphotransferase activity" EXACT [EC:2.7.1.121]
xref: EC:2.7.1.121
xref: MetaCyc:2.7.1.121-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047325
name: inositol tetrakisphosphate 1-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.134, MetaCyc:2.7.1.134-RXN]
synonym: "1D-myo-inositol-tetrakisphosphate 1-kinase activity" EXACT [EC:2.7.1.134]
synonym: "1D-myo-inositol-trisphosphate 5-kinase activity" RELATED [EC:2.7.1.134]
synonym: "1D-myo-inositol-trisphosphate 6-kinase activity" RELATED [EC:2.7.1.134]
synonym: "ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.134]
synonym: "ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.134]
synonym: "ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.134]
synonym: "inositol 3,4,5,6-tetrakisphosphate 1-kinase activity" EXACT []
synonym: "inositol-tetrakisphosphate 1-kinase activity" EXACT []
synonym: "inositol-trisphosphate 5-kinase activity" RELATED [EC:2.7.1.134]
synonym: "inositol-trisphosphate 6-kinase activity" RELATED [EC:2.7.1.134]
xref: EC:2.7.1.134
xref: MetaCyc:2.7.1.134-RXN
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0047326
name: inositol tetrakisphosphate 5-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.140, MetaCyc:2.7.1.140-RXN]
synonym: "1D-myo-inositol-tetrakisphosphate 5-kinase activity" EXACT []
synonym: "ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.140]
synonym: "inositol 1,3,4,6-tetrakisphosphate 5-kinase activity" EXACT []
synonym: "inositol-tetrakisphosphate 5-kinase activity" EXACT []
xref: EC:2.7.1.140
xref: MetaCyc:2.7.1.140-RXN
is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity

[Term]
id: GO:0047327
name: glycerol-3-phosphate-glucose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucose + glycerol-3-phosphate = glucose-6-phosphate + glycerol." [EC:2.7.1.142, MetaCyc:2.7.1.142-RXN]
synonym: "sn-glycerol-3-phosphate:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.142]
xref: EC:2.7.1.142
xref: MetaCyc:2.7.1.142-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047328
name: acyl-phosphate-hexose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-hexose + acyl phosphate = D-hexose phosphate + an acid." [EC:2.7.1.61, MetaCyc:2.7.1.61-RXN]
synonym: "acyl-phosphate:D-hexose phosphotransferase activity" EXACT [EC:2.7.1.61]
synonym: "hexose phosphate:hexose phosphotransferase activity" EXACT [EC:2.7.1.61]
xref: EC:2.7.1.61
xref: MetaCyc:2.7.1.61-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047329
name: phosphoramidate-hexose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3." [EC:2.7.1.62, MetaCyc:2.7.1.62-RXN]
synonym: "phosphoramidate-hexose transphosphorylase activity" EXACT [EC:2.7.1.62]
synonym: "phosphoramidate:hexose 1-phosphotransferase activity" EXACT [EC:2.7.1.62]
synonym: "phosphoramidic-hexose transphosphorylase activity" EXACT [EC:2.7.1.62]
xref: EC:2.7.1.62
xref: MetaCyc:2.7.1.62-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047330
name: polyphosphate-glucose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucose + long chain polyphosphate = glucose-6-phosphate + long chain polyphosphate." [EC:2.7.1.63, MetaCyc:2.7.1.63-RXN]
subset: gosubset_prok
synonym: "polyphosphate glucokinase activity" EXACT [EC:2.7.1.63]
synonym: "polyphosphate-D-(+)-glucose-6-phosphotransferase activity" EXACT [EC:2.7.1.63]
synonym: "polyphosphate-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.63]
synonym: "polyphosphate:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.63]
xref: EC:2.7.1.63
xref: MetaCyc:2.7.1.63-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047331
name: diphosphate-glycerol phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol + pyrophosphate = phosphate + glycerol-3-phosphate." [EC:2.7.1.79, MetaCyc:2.7.1.79-RXN]
synonym: "diphosphate:glycerol 1-phosphotransferase activity" EXACT [EC:2.7.1.79]
synonym: "PPi-glycerol phosphotransferase activity" EXACT [EC:2.7.1.79]
synonym: "pyrophosphate--glycerol phosphotransferase activity" EXACT [EC:2.7.1.79]
xref: EC:2.7.1.79
xref: MetaCyc:2.7.1.79-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047332
name: diphosphate-serine phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + pyrophosphate = phosphate + 3-phospho-serine." [EC:2.7.1.80, MetaCyc:2.7.1.80-RXN]
synonym: "diphosphate:L-serine O-phosphotransferase activity" EXACT [EC:2.7.1.80]
synonym: "pyrophosphate--serine phosphotransferase activity" EXACT [EC:2.7.1.80]
synonym: "pyrophosphate-L-serine phosphotransferase activity" EXACT [EC:2.7.1.80]
xref: EC:2.7.1.80
xref: MetaCyc:2.7.1.80-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047333
name: dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrostreptomycin 6-phosphate + ATP = dihydrostreptomycin 3'-alpha-6-bisphosphate + ADP." [EC:2.7.1.88, MetaCyc:2.7.1.88-RXN]
synonym: "ATP:dihydrostreptomycin-6-P 3'alpha-phosphotransferase activity" EXACT [EC:2.7.1.88]
synonym: "ATP:dihydrostreptomycin-6-phosphate 3'alpha-phosphotransferase activity" EXACT [EC:2.7.1.88]
synonym: "dihydrostreptomycin 6-phosphate kinase (phosphorylating)" EXACT [EC:2.7.1.88]
synonym: "dihydrostreptomycin-6-phosphate 3'alpha-kinase activity" EXACT [EC:2.7.1.88]
xref: EC:2.7.1.88
xref: MetaCyc:2.7.1.88-RXN
is_a: GO:0034071 ! aminoglycoside phosphotransferase activity

[Term]
id: GO:0047334
name: diphosphate-fructose-6-phosphate 1-phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: fructose-6-phosphate + pyrophosphate = phosphate + fructose-1,6-bisphosphate." [EC:2.7.1.90, MetaCyc:2.7.1.90-RXN]
subset: gosubset_prok
synonym: "6-phosphofructokinase (diphosphate) activity" EXACT [EC:2.7.1.90]
synonym: "6-phosphofructokinase (pyrophosphate) activity" EXACT [EC:2.7.1.90]
synonym: "diphosphate-dependent 6-phosphofructose-1-kinase activity" EXACT [EC:2.7.1.90]
synonym: "diphosphate:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.90]
synonym: "inorganic pyrophosphate-dependent phosphofructokinase activity" EXACT [EC:2.7.1.90]
synonym: "inorganic pyrophosphate-phosphofructokinase activity" EXACT [EC:2.7.1.90]
synonym: "pyrophosphate--fructose 6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.90]
synonym: "pyrophosphate-dependent 6-phosphofructose-1-kinase activity" EXACT [EC:2.7.1.90]
synonym: "pyrophosphate-dependent phosphofructo-1-kinase activity" EXACT [EC:2.7.1.90]
synonym: "pyrophosphate-fructose 6-phosphate phosphotransferase activity" EXACT [EC:2.7.1.90]
xref: EC:2.7.1.90
xref: MetaCyc:2.7.1.90-RXN
is_a: GO:0008443 ! phosphofructokinase activity

[Term]
id: GO:0047335
name: 3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate." [EC:2.7.4.17, MetaCyc:2.7.4.17-RXN]
synonym: "1,3-diphosphoglycerate-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17]
synonym: "3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17]
synonym: "diphosphoglycerate-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.17]
xref: EC:2.7.4.17
xref: MetaCyc:2.7.4.17-RXN
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0047336
name: 5-methyldeoxycytidine-5'-phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxy-5-methylcytidylate + ATP = 5-methyldeoxycytidine diphosphate + ADP." [EC:2.7.4.19, MetaCyc:2.7.4.19-RXN]
synonym: "ATP:5-methyldeoxycytidine-5'-phosphate phosphotransferase activity" EXACT [EC:2.7.4.19]
xref: EC:2.7.4.19
xref: MetaCyc:2.7.4.19-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0047337
name: dolichyl-diphosphate-polyphosphate phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl diphosphate + long-chain-polyphosphate = dolichol-phosphate + long-chain-polyphosphate." [EC:2.7.4.20, MetaCyc:2.7.4.20-RXN]
synonym: "dolichyl-diphosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.20]
synonym: "dolichylpyrophosphate:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.20]
xref: EC:2.7.4.20
xref: MetaCyc:2.7.4.20-RXN
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0047338
name: UTP:xylose-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-xylose 1-phosphate + UTP = UDP-D-xylose + diphosphate." [EC:2.7.7.11, MetaCyc:2.7.7.11-RXN]
synonym: "UDP-xylose pyrophosphorylase activity" EXACT [EC:2.7.7.11]
synonym: "uridine diphosphoxylose pyrophosphorylase activity" EXACT [EC:2.7.7.11]
synonym: "uridylyltransferase, xylose 1-phosphate" EXACT [EC:2.7.7.11]
synonym: "UTP-xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11]
synonym: "UTP:alpha-D-xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11]
synonym: "xylose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11]
synonym: "xylose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.11]
xref: EC:2.7.7.11
xref: MetaCyc:2.7.7.11-RXN
is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity

[Term]
id: GO:0047339
name: nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity
namespace: molecular_function
alt_id: GO:0047340
def: "Catalysis of the reaction: hexose 1-phosphate + nucleoside triphosphate = NDP-hexose + diphosphate." [EC:2.7.7.28, MetaCyc:2.7.7.28-RXN]
synonym: "GDP hexose pyrophosphorylase activity" NARROW [EC:2.7.7.28]
synonym: "GTP:alpha-D-hexose-1-phosphate guanylyltransferase activity" NARROW [EC:2.7.7.28]
synonym: "GTP:hexose-1-phosphate guanylyltransferase activity" NARROW []
synonym: "guanosine diphosphohexose pyrophosphorylase activity" NARROW [EC:2.7.7.28]
synonym: "hexose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.28]
synonym: "hexose 1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28]
synonym: "hexose nucleotidylating enzyme activity" EXACT [EC:2.7.7.28]
synonym: "hexose-1-phosphate guanylyltransferase activity" NARROW []
synonym: "NDP hexose pyrophosphorylase activity" EXACT [EC:2.7.7.28]
synonym: "NDP-hexose diphosphorylase activity" EXACT []
synonym: "NDP-hexose pyrophosphorylase activity" EXACT []
synonym: "NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28]
synonym: "NTP:hexose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28]
synonym: "nucleoside diphosphohexose pyrophosphorylase activity" EXACT [EC:2.7.7.28]
synonym: "nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.28]
xref: EC:2.7.7.28
xref: MetaCyc:2.7.7.28-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0047341
name: fucose-1-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-fucose 1-phosphate + GTP = guanosine diphosphate fucose + diphosphate." [EC:2.7.7.30, MetaCyc:2.7.7.30-RXN]
synonym: "GDP fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30]
synonym: "GDP-fucose diphosphorylase activity" EXACT [EC:2.7.7.30]
synonym: "GDP-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30]
synonym: "GDP-L-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30]
synonym: "GTP:beta-L-fucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.30]
synonym: "GTP:fucose-1-phosphate guanylyltransferase activity" EXACT []
synonym: "GTP:L-fucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.30]
synonym: "guanosine diphosphate L-fucose pyrophosphorylase activity" EXACT [EC:2.7.7.30]
xref: EC:2.7.7.30
xref: MetaCyc:2.7.7.30-RXN
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0047342
name: galactose-1-phosphate thymidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-galactose-1-phosphate + dTTP = dTDP-D-galactose + diphosphate." [EC:2.7.7.32, MetaCyc:2.7.7.32-RXN]
synonym: "dTDP galactose pyrophosphorylase activity" EXACT [EC:2.7.7.32]
synonym: "dTDP-galactose diphosphorylase activity" EXACT [EC:2.7.7.32]
synonym: "dTDP-galactose pyrophosphorylase activity" EXACT [EC:2.7.7.32]
synonym: "dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.32]
synonym: "galactose 1-phosphate thymidylyl transferase activity" EXACT [EC:2.7.7.32]
synonym: "thymidine diphosphogalactose pyrophosphorylase activity" EXACT [EC:2.7.7.32]
synonym: "thymidine triphosphate:alpha-D-galactose 1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.32]
xref: EC:2.7.7.32
xref: MetaCyc:2.7.7.32-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0047343
name: glucose-1-phosphate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucose-1-phosphate + CTP = CDP-D-glucose + diphosphate." [EC:2.7.7.33, MetaCyc:2.7.7.33-RXN]
subset: gosubset_prok
synonym: "CDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33]
synonym: "CDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.33]
synonym: "CDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33]
synonym: "CTP:alpha-D-glucose-1-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.33]
synonym: "CTP:D-glucose-1-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.33]
synonym: "CTP:glucose-1-phosphate cytidylyltransferase activity" EXACT []
synonym: "cytidine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33]
synonym: "cytidine diphosphate-D-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.33]
synonym: "cytidine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.33]
xref: EC:2.7.7.33
xref: MetaCyc:2.7.7.33-RXN
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0047344
name: glucose-1-phosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glucose-1-phosphate + GTP = GDP-D-glucose + diphosphate." [EC:2.7.7.34, MetaCyc:2.7.7.34-RXN]
synonym: "GDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.34]
synonym: "GDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.34]
synonym: "GDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.34]
synonym: "GTP:alpha-D-glucose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.34]
synonym: "GTP:glucose-1-phosphate guanylyltransferase activity" EXACT []
synonym: "guanosine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.34]
xref: EC:2.7.7.34
xref: MetaCyc:2.7.7.34-RXN
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0047345
name: ribose-5-phosphate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ribose-5-phosphate + ADP = phosphate + adenosine diphosphate ribose." [EC:2.7.7.35, MetaCyc:2.7.7.35-RXN]
synonym: "adenosine diphosphoribose phosphorylase activity" EXACT [EC:2.7.7.35]
synonym: "ADP ribose phosphorylase activity" EXACT [EC:2.7.7.35]
synonym: "ADP-ribose phosphorylase activity" EXACT [EC:2.7.7.35]
synonym: "ADP:D-ribose-5-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.35]
synonym: "ADP:ribose-5-phosphate adenylyltransferase activity" EXACT []
xref: EC:2.7.7.35
xref: MetaCyc:2.7.7.35-RXN
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0047346
name: aldose-1-phosphate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: aldose 1-phosphate + ADP = phosphate + ADP-aldose." [EC:2.7.7.36, MetaCyc:2.7.7.36-RXN]
synonym: "adenosine diphosphate glucose:orthophosphate adenylyltransferase activity" EXACT [EC:2.7.7.36]
synonym: "adenosine diphosphosugar phosphorylase activity" EXACT [EC:2.7.7.36]
synonym: "ADP sugar phosphorylase activity" EXACT [EC:2.7.7.36]
synonym: "ADP-aldose phosphorylase activity" EXACT [EC:2.7.7.36]
synonym: "ADP-sugar phosphorylase activity" BROAD [EC:2.7.7.36]
synonym: "ADP:aldose-1-phosphate adenylyltransferase activity" EXACT []
synonym: "ADP:alpha-D-aldose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.36]
synonym: "ADPaldose phosphorylase activity" EXACT [EC:2.7.7.36]
synonym: "sugar-1-phosphate adenylyltransferase activity" BROAD [EC:2.7.7.36]
xref: EC:2.7.7.36
xref: MetaCyc:2.7.7.36-RXN
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0047347
name: aldose-1-phosphate nucleotidyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: aldose 1-phosphate + NDP = phosphate + NDP-aldose." [EC:2.7.7.37, MetaCyc:2.7.7.37-RXN]
subset: gosubset_prok
synonym: "glucose 1-phosphate inosityltransferase activity" EXACT [EC:2.7.7.37]
synonym: "NDP sugar phosphorylase activity" EXACT [EC:2.7.7.37]
synonym: "NDP-aldose phosphorylase activity" EXACT [EC:2.7.7.37]
synonym: "NDP-sugar phosphorylase activity" BROAD [EC:2.7.7.37]
synonym: "NDP:aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37]
synonym: "NDP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37]
synonym: "NDPaldose phosphorylase activity" EXACT [EC:2.7.7.37]
synonym: "nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37]
synonym: "nucleoside diphosphosugar phosphorylase activity" EXACT [EC:2.7.7.37]
synonym: "sugar nucleotide phosphorylase activity" EXACT [EC:2.7.7.37]
synonym: "sugar phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.37]
synonym: "sugar-1-phosphate nucleotidyltransferase activity" BROAD [EC:2.7.7.37]
xref: EC:2.7.7.37
xref: MetaCyc:2.7.7.37-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0047348
name: glycerol-3-phosphate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol-3-phosphate + CTP = CDPglycerol + diphosphate." [EC:2.7.7.39, MetaCyc:2.7.7.39-RXN]
subset: gosubset_prok
synonym: "CDP-glycerol diphosphorylase activity" EXACT [EC:2.7.7.39]
synonym: "CDP-glycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39]
synonym: "CTP:glycerol 3-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.39]
synonym: "CTP:glycerol-3-phosphate cytidylyltransferase activity" EXACT []
synonym: "CTP:sn-glycerol-3-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.39]
synonym: "cytidine diphosphate glycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39]
synonym: "cytidine diphosphoglycerol pyrophosphorylase activity" EXACT [EC:2.7.7.39]
synonym: "Gro-PCT" RELATED [EC:2.7.7.39]
xref: EC:2.7.7.39
xref: MetaCyc:2.7.7.39-RXN
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0047349
name: D-ribitol-5-phosphate cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribitol 5-phosphate + CTP = CDP-ribitol + diphosphate." [EC:2.7.7.40, MetaCyc:2.7.7.40-RXN]
subset: gosubset_prok
synonym: "CDP ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40]
synonym: "CDP-ribitol diphosphorylase activity" EXACT [EC:2.7.7.40]
synonym: "CDP-ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40]
synonym: "CTP:D-ribitol-5-phosphate cytidylyltransferase activity" EXACT []
synonym: "cytidine diphosphate ribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40]
synonym: "cytidine diphosphoribitol pyrophosphorylase activity" EXACT [EC:2.7.7.40]
synonym: "ribitol 5-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.40]
xref: EC:2.7.7.40
xref: MetaCyc:2.7.7.40-RXN
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0047350
name: glucuronate-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phospho-alpha-D-glucuronate + UTP = UDP-D-glucuronate + diphosphate." [EC:2.7.7.44, MetaCyc:2.7.7.44-RXN]
synonym: "UDP-D-glucuronic acid pyrophosphorylase activity" EXACT [EC:2.7.7.44]
synonym: "UDP-glucuronate pyrophosphorylase activity" EXACT [EC:2.7.7.44]
synonym: "UDP-glucuronic acid pyrophosphorylase activity" EXACT [EC:2.7.7.44]
synonym: "uridine diphosphoglucuronic pyrophosphorylase activity" EXACT [EC:2.7.7.44]
synonym: "UTP:1-phospho-alpha-D-glucuronate uridylyltransferase activity" EXACT [EC:2.7.7.44]
synonym: "UTP:glucuronate-1-phosphate uridylyltransferase activity" EXACT []
xref: EC:2.7.7.44
xref: MetaCyc:2.7.7.44-RXN
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0047351
name: guanosine-triphosphate guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 GTP = P1,P4-bis(5'-guanosyl) tetraphosphate + diphosphate." [EC:2.7.7.45, MetaCyc:2.7.7.45-RXN]
synonym: "GTP:GTP guanylyltransferase activity" EXACT []
xref: EC:2.7.7.45
xref: MetaCyc:2.7.7.45-RXN
is_a: GO:0070568 ! guanylyltransferase activity

[Term]
id: GO:0047352
name: adenylylsulfate-ammonia adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: NH3 + APS = SO4(2-) (sulfate) + adenosine 5'-phosphoramidate." [EC:2.7.7.51, MetaCyc:2.7.7.51-RXN]
synonym: "adenylylsulfate:ammonia adenylyltransferase activity" EXACT [EC:2.7.7.51]
synonym: "adenylylsulphate-ammonia adenylyltransferase activity" EXACT []
synonym: "APSAT" RELATED [EC:2.7.7.51]
xref: EC:2.7.7.51
xref: MetaCyc:2.7.7.51-RXN
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0047353
name: N-methylphosphoethanolamine cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methylethanolamine phosphate + CTP = CDP-N-methylethanolamin + diphosphate." [EC:2.7.7.57, MetaCyc:2.7.7.57-RXN]
synonym: "CTP:N-methylethanolamine-phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.57]
synonym: "CTP:N-methylphosphoethanolamine cytidylyltransferase activity" EXACT []
synonym: "CTP:P-MEA cytidylyltransferase activity" EXACT [EC:2.7.7.57]
synonym: "monomethylethanolamine phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.57]
xref: EC:2.7.7.57
xref: MetaCyc:2.7.7.57-RXN
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0047354
name: sphingosine cholinephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: sphingosine + CDP-choline = sphingosyl-phosphocholine + CMP." [EC:2.7.8.10, MetaCyc:2.7.8.10-RXN]
synonym: "CDP-choline-sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10]
synonym: "CDP-choline:sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10]
synonym: "cytidine diphosphocholine-sphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.10]
synonym: "phosphorylcholine-sphingosine transferase activity" EXACT [EC:2.7.8.10]
synonym: "sphingosine choline phosphotransferase activity" EXACT []
xref: EC:2.7.8.10
xref: MetaCyc:2.7.8.10-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047355
name: CDP-glycerol glycerophosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP." [EC:2.7.8.12, MetaCyc:2.7.8.12-RXN]
subset: gosubset_prok
synonym: "CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase activity" EXACT [EC:2.7.8.12]
synonym: "CDPglycerol glycerophosphotransferase activity" EXACT [EC:2.7.8.12]
synonym: "CGPTase activity" EXACT [EC:2.7.8.12]
synonym: "cytidine diphosphoglycerol glycerophosphotransferase activity" EXACT [EC:2.7.8.12]
synonym: "glycerophosphate synthetase activity" EXACT [EC:2.7.8.12]
synonym: "poly(glycerol phosphate) polymerase activity" EXACT [EC:2.7.8.12]
synonym: "teichoic acid glycerol transferase activity" EXACT [EC:2.7.8.12]
synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.12]
xref: EC:2.7.8.12
xref: MetaCyc:2.7.8.12-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047356
name: CDP-ribitol ribitolphosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ribitol phosphate(n) + CDP-ribitol = ribitol phosphate(n+1) + CMP." [EC:2.7.8.14, MetaCyc:2.7.8.14-RXN]
subset: gosubset_prok
synonym: "CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase activity" EXACT [EC:2.7.8.14]
synonym: "CDPribitol ribitolphosphotransferase activity" EXACT [EC:2.7.8.14]
synonym: "poly(ribitol phosphate) synthetase activity" EXACT [EC:2.7.8.14]
synonym: "polyribitol phosphate polymerase activity" EXACT [EC:2.7.8.14]
synonym: "polyribitol phosphate synthetase activity" EXACT [EC:2.7.8.14]
synonym: "teichoate synthase activity" EXACT [EC:2.7.8.14]
synonym: "teichoate synthetase activity" EXACT [EC:2.7.8.14]
synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.14]
xref: EC:2.7.8.14
xref: MetaCyc:2.7.8.14-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047357
name: UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + UDP-galactose = UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP." [EC:2.7.8.18, MetaCyc:2.7.8.18-RXN]
synonym: "galactose-1-phosphotransferase activity" EXACT [EC:2.7.8.18]
synonym: "galactosyl phosphotransferase activity" EXACT [EC:2.7.8.18]
synonym: "UDP-galactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18]
synonym: "UDPgalactose-UDP-N-acetylglucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18]
synonym: "UDPgalactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity" EXACT [EC:2.7.8.18]
synonym: "uridine diphosphogalactose-uridine diphosphoacetylglucosamine galactose-1-phosphotransferase activity" EXACT [EC:2.7.8.18]
xref: EC:2.7.8.18
xref: MetaCyc:2.7.8.18-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047358
name: UDP-glucose-glycoprotein glucose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycoprotein D-mannose + UDP-D-glucose = glycoprotein 6-(D-glucose-1-phospho)-D-mannose + UMP." [EC:2.7.8.19, MetaCyc:2.7.8.19-RXN]
synonym: "Glc-phosphotransferase activity" EXACT [EC:2.7.8.19]
synonym: "GlcPTase activity" EXACT [EC:2.7.8.19]
synonym: "UDP-glucose:glycoprotein glucose-1-phosphotransferase activity" EXACT [EC:2.7.8.19]
synonym: "UDP-glucose:glycoprotein-D-mannose glucosephosphotransferase activity" EXACT [EC:2.7.8.19]
synonym: "UDPglucose-glycoprotein glucose phosphotransferase activity" EXACT [EC:2.7.8.19]
synonym: "UDPglucose:glycoprotein-D-mannose glucosephosphotransferase activity" EXACT [EC:2.7.8.19]
synonym: "uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase activity" EXACT [EC:2.7.8.19]
xref: EC:2.7.8.19
xref: MetaCyc:2.7.8.19-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047359
name: 1-alkenyl-2-acylglycerol choline phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkenyl-2-acylglycerol + CDP-choline = plasmenylcholine + CMP." [EC:2.7.8.22, MetaCyc:2.7.8.22-RXN]
synonym: "CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase activity" EXACT [EC:2.7.8.22]
synonym: "CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.22]
xref: EC:2.7.8.22
xref: MetaCyc:2.7.8.22-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047360
name: undecaprenyl-phosphate galactose phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: undecaprenyl phosphate + UDP-galactose = alpha-D-galactosyl-diphosphoundecaprenol + UMP." [EC:2.7.8.6, MetaCyc:2.7.8.6-RXN]
subset: gosubset_prok
synonym: "poly(isoprenol)-phosphate galactose phosphotransferase activity" EXACT [EC:2.7.8.6]
synonym: "poly(isoprenol)-phosphate galactosephosphotransferase activity" EXACT [EC:2.7.8.6]
synonym: "Poly(isoprenol)-phosphate galactosephosphotransferase activity" EXACT [EC:2.7.8.6]
synonym: "poly(isoprenyl)phosphate galactosephosphatetransferase activity" EXACT [EC:2.7.8.6]
synonym: "UDP-galactose:undecaprenyl-phosphate galactose phosphotransferase activity" EXACT [EC:2.7.8.6]
synonym: "undecaprenyl phosphate galactosyl-1-phosphate transferase activity" EXACT [EC:2.7.8.6]
xref: EC:2.7.8.6
xref: MetaCyc:2.7.8.6-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047361
name: phosphomannan mannosephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphomannan(n) + GDP-mannose = phosphomannan(n+1) + GMP." [EC:2.7.8.9, MetaCyc:2.7.8.9-RXN]
synonym: "GDP-mannose:phosphomannan mannose phosphotransferase activity" EXACT [EC:2.7.8.9]
xref: EC:2.7.8.9
xref: MetaCyc:2.7.8.9-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047362
name: thiosulfate-dithiol sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dithioerythritol + S2O3(2-) (thiosulfate) = H2S + dithioerythritol disulfide + SO3(2-) (sulfite)." [EC:2.8.1.5, MetaCyc:2.8.1.5-RXN]
synonym: "thiosulfate reductase activity" EXACT [EC:2.8.1.5]
synonym: "thiosulfate:dithioerythritol sulfurtransferase activity" EXACT [EC:2.8.1.5]
synonym: "thiosulphate-dithiol sulphurtransferase activity" EXACT []
synonym: "TSR" RELATED [EC:2.8.1.5]
xref: EC:2.8.1.5
xref: MetaCyc:2.8.1.5-RXN
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0047363
name: triglucosylalkylacylglycerol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + 3'-phosphoadenosine 5'-phosphosulfate = 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + adenosine 3',5'-bisphosphate." [EC:2.8.2.19, MetaCyc:2.8.2.19-RXN]
synonym: "3'-phosphoadenylyl-sulfate:triglucosyl-1-O-alkyl-2-O-acylglycerol 6-sulfotransferase activity" EXACT [EC:2.8.2.19]
synonym: "triglucosylalkylacylglycerol sulphotransferase activity" EXACT []
synonym: "triglucosylmonoalkylmonoacyl sulfotransferase activity" EXACT [EC:2.8.2.19]
xref: EC:2.8.2.19
xref: MetaCyc:2.8.2.19-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047364
name: desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: desulfoglucotropeolin + 3'-phosphoadenosine 5'-phosphosulfate = glucotropeolin + adenosine 3',5'-bisphosphate." [EC:2.8.2.24, MetaCyc:2.8.2.24-RXN]
synonym: "3'-phosphoadenosine-5'-phosphosulfate:desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24]
synonym: "3'-phosphoadenylyl-sulfate:desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24]
synonym: "desulphoglucosinolate sulphotransferase activity" EXACT []
synonym: "PAPS-desulfoglucosinolate sulfotransferase activity" EXACT [EC:2.8.2.24]
xref: EC:2.8.2.24
xref: MetaCyc:2.8.2.24-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047365
name: quercetin-3-sulfate 3'-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: quercetin 3-sulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3'-bissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.26, MetaCyc:2.8.2.26-RXN]
synonym: "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfotransferase activity" EXACT [EC:2.8.2.26]
synonym: "3'-sulfotransferase activity" EXACT [EC:2.8.2.26]
synonym: "flavonol 3'-sulfotransferase activity" EXACT [EC:2.8.2.26]
synonym: "PAPS:flavonol 3-sulfate 3'-sulfotransferase activity" EXACT [EC:2.8.2.26]
synonym: "quercetin-3-sulphate 3'-sulphotransferase activity" EXACT []
xref: EC:2.8.2.26
xref: MetaCyc:2.8.2.26-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047366
name: quercetin-3-sulfate 4'-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: quercetin 3-sulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,4'-bissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.27, MetaCyc:2.8.2.27-RXN]
synonym: "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 4'-sulfotransferase activity" EXACT [EC:2.8.2.27]
synonym: "flavonol 4'-sulfotransferase activity" EXACT [EC:2.8.2.27]
synonym: "PAPS:flavonol 3-sulfate 4'-sulfotransferase activity" EXACT [EC:2.8.2.27]
synonym: "quercetin-3-sulphate 4'-sulphotransferase activity" EXACT []
xref: EC:2.8.2.27
xref: MetaCyc:2.8.2.27-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047367
name: quercetin-3,3'-bissulfate 7-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.28, MetaCyc:2.8.2.28-RXN]
synonym: "3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfotransferase activity" EXACT [EC:2.8.2.28]
synonym: "7-sulfotransferase activity" EXACT [EC:2.8.2.28]
synonym: "flavonol 7-sulfotransferase activity" EXACT [EC:2.8.2.28]
synonym: "PAPS:flavonol 3,3'/3,4'-disulfate 7-sulfotransferase activity" EXACT [EC:2.8.2.28]
synonym: "quercetin-3,3'-bissulphate 7-sulphotransferase activity" EXACT []
xref: EC:2.8.2.28
xref: MetaCyc:2.8.2.28-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047368
name: UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine 4-sulfate + 3'-phosphoadenosine 5'-phosphosulfate = UDP-N-acetyl-D-galactosamine 4,6-bissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.7, MetaCyc:2.8.2.7-RXN]
synonym: "3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfotransferase activity" EXACT [EC:2.8.2.7]
synonym: "UDP-N-acetylgalactosamine-4-sulphate sulphotransferase activity" EXACT []
synonym: "uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase activity" EXACT [EC:2.8.2.7]
synonym: "uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase activity" EXACT [EC:2.8.2.7]
xref: EC:2.8.2.7
xref: MetaCyc:2.8.2.7-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047369
name: succinate-hydroxymethylglutarate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate." [EC:2.8.3.13, MetaCyc:2.8.3.13-RXN]
synonym: "dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase activity" EXACT [EC:2.8.3.13]
synonym: "hydroxymethylglutarate coenzyme A-transferase activity" EXACT [EC:2.8.3.13]
synonym: "succinate:(S)-3-hydroxy-3-methylglutarate CoA-transferase activity" EXACT [EC:2.8.3.13]
xref: EC:2.8.3.13
xref: MetaCyc:2.8.3.13-RXN
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047370
name: succinate-citramalate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate." [EC:2.8.3.7, MetaCyc:2.8.3.7-RXN]
synonym: "citramalate coenzyme A-transferase activity" EXACT [EC:2.8.3.7]
synonym: "itaconate CoA-transferase activity" EXACT [EC:2.8.3.7]
synonym: "succinyl coenzyme A-citramalyl coenzyme A transferase activity" EXACT [EC:2.8.3.7]
synonym: "succinyl-CoA:citramalate CoA-transferase activity" EXACT [EC:2.8.3.7]
xref: EC:2.8.3.7
xref: MetaCyc:2.8.3.7-RXN
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047371
name: butyrate-acetoacetate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoacetate + butyryl-CoA = acetoacetyl-CoA + butyrate." [EC:2.8.3.9, MetaCyc:2.8.3.9-RXN]
subset: gosubset_prok
synonym: "butanoyl-CoA:acetoacetate CoA-transferase activity" EXACT [EC:2.8.3.9]
synonym: "butyryl coenzyme A-acetoacetate coenzyme A-transferase activity" EXACT [EC:2.8.3.9]
synonym: "butyryl-CoA-acetoacetate CoA-transferase activity" EXACT [EC:2.8.3.9]
xref: EC:2.8.3.9
xref: MetaCyc:2.8.3.9-RXN
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047372
name: acylglycerol lipase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol." [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN]
subset: gosubset_prok
synonym: "fatty acyl monoester lipase activity" EXACT [EC:3.1.1.23]
synonym: "glycerol-ester acylhydrolase activity" EXACT [EC:3.1.1.23]
synonym: "monoacylglycerol hydrolase activity" EXACT [EC:3.1.1.23]
synonym: "monoacylglycerol lipase activity" EXACT [EC:3.1.1.23]
synonym: "monoacylglycerolipase activity" EXACT [EC:3.1.1.23]
synonym: "monoglyceridase activity" EXACT [EC:3.1.1.23]
synonym: "monoglyceride hydrolase activity" EXACT [EC:3.1.1.23]
synonym: "monoglyceride lipase activity" EXACT [EC:3.1.1.23]
synonym: "monoglyceridyllipase activity" EXACT [EC:3.1.1.23]
xref: EC:3.1.1.23
xref: MetaCyc:3.1.1.23-RXN
xref: Reactome:83299 "acylglycerol lipase activity"
is_a: GO:0004091 ! carboxylesterase activity
is_a: GO:0016298 ! lipase activity

[Term]
id: GO:0047373
name: acetoxybutynylbithiophene deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 5-(4-acetoxybut-1-ynyl)-2-2'-bithiophene = acetate + 5-(4-hydroxybut-1-ynyl)-2,2'-bithiophene." [EC:3.1.1.54, MetaCyc:3.1.1.54-RXN]
synonym: "5-(4-acetoxy-1-butynyl)-2,2'-bithiophene:acetate esterase activity" EXACT [EC:3.1.1.54]
synonym: "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene O-acetylhydrolase activity" EXACT [EC:3.1.1.54]
synonym: "acetoxybutynylbithiophene esterase activity" EXACT [EC:3.1.1.54]
xref: EC:3.1.1.54
xref: MetaCyc:3.1.1.54-RXN
is_a: GO:0004091 ! carboxylesterase activity
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047374
name: methylumbelliferyl-acetate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methylumbelliferyl acetate + H2O = acetate + 4-methylumbelliferone." [EC:3.1.1.56, MetaCyc:3.1.1.56-RXN]
synonym: "4-methylumbelliferyl-acetate acylhydrolase activity" EXACT [EC:3.1.1.56]
synonym: "esterase D activity" RELATED [EC:3.1.1.56]
xref: EC:3.1.1.56
xref: MetaCyc:3.1.1.56-RXN
is_a: GO:0004091 ! carboxylesterase activity
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047375
name: N-acetylgalactosaminoglycan deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosaminoglycan = acetate + D-galactosaminoglycan." [EC:3.1.1.58, MetaCyc:3.1.1.58-RXN]
synonym: "N-acetyl galactosaminoglycan deacetylase activity" EXACT [EC:3.1.1.58]
synonym: "N-acetyl-D-galactosaminoglycan acetylhydrolase activity" EXACT [EC:3.1.1.58]
synonym: "polysaccharide deacetylase activity" EXACT [EC:3.1.1.58]
synonym: "Vi-polysaccharide deacetylase activity" EXACT [EC:3.1.1.58]
xref: EC:3.1.1.58
xref: MetaCyc:3.1.1.58-RXN
is_a: GO:0004091 ! carboxylesterase activity
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047376
name: all-trans-retinyl-palmitate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + retinol-palmitate = palmitate + retinol." [EC:3.1.1.64, MetaCyc:3.1.1.64-RXN]
synonym: "all-trans-retinyl-palmitate acylhydrolase activity" EXACT [EC:3.1.1.64]
xref: EC:3.1.1.64
xref: MetaCyc:3.1.1.64-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047377
name: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene = acetate + 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene." [EC:3.1.1.66, MetaCyc:3.1.1.66-RXN]
synonym: "3,4-diacetoxybutinylbithiophene:4-acetate esterase activity" EXACT [EC:3.1.1.66]
synonym: "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene acetylhydrolase activity" EXACT [EC:3.1.1.66]
synonym: "diacetoxybutynylbithiophene acetate esterase activity" EXACT [EC:3.1.1.66]
xref: EC:3.1.1.66
xref: MetaCyc:3.1.1.66-RXN
is_a: GO:0004091 ! carboxylesterase activity
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047378
name: acetylalkylglycerol acetylhydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 2-acetyl-1-alkyl-sn-glycerol = acetate + 1-alkyl-sn-glycerol." [EC:3.1.1.71, MetaCyc:3.1.1.71-RXN]
synonym: "2-acetyl-1-alkyl-sn-glycerol acetylhydrolase activity" EXACT [EC:3.1.1.71]
synonym: "alkylacetylglycerol acetylhydrolase activity" EXACT [EC:3.1.1.71]
xref: EC:3.1.1.71
xref: MetaCyc:3.1.1.71-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047379
name: ADP-dependent short-chain-acyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a short-chain acyl-CoA = a short-chain carboxylate + CoA." [EC:3.1.2.18, MetaCyc:3.1.2.18-RXN]
synonym: "ADP-dependent-short-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.18]
synonym: "propionyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.18]
synonym: "propionyl-CoA hydrolase activity" EXACT [EC:3.1.2.18]
synonym: "propionyl-CoA thioesterase activity" EXACT [EC:3.1.2.18]
synonym: "short-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.18]
synonym: "short-chain acyl-CoA hydrolase activity" EXACT [EC:3.1.2.18]
synonym: "short-chain acyl-CoA thioesterase activity" EXACT [EC:3.1.2.18]
xref: EC:3.1.2.18
xref: MetaCyc:3.1.2.18-RXN
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0047380
name: ADP-dependent medium-chain-acyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA." [EC:3.1.2.19, MetaCyc:3.1.2.19-RXN]
subset: gosubset_prok
synonym: "ADP-dependent-medium-chain-acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "medium-chain acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "medium-chain acyl-CoA hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "medium-chain acyl-thioester hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "medium-chain hydrolase activity" EXACT [EC:3.1.2.19]
synonym: "myristoyl-CoA thioesterase activity" EXACT [EC:3.1.2.19]
xref: EC:3.1.2.19
xref: MetaCyc:3.1.2.19-RXN
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0047381
name: dodecanoyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
alt_id: GO:0016294
def: "Catalysis of the reaction: H2O + dodecanoyl-[acyl-carrier protein] = dodecanoate + [acyl-carrier protein]." [EC:3.1.2.21, MetaCyc:3.1.2.21-RXN]
synonym: "dodecanoyl-[acyl-carrier protein] hydrolase activity" EXACT []
synonym: "dodecanoyl-ACP hydrolase activity" EXACT []
synonym: "dodecanoyl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.21]
synonym: "dodecyl-[acyl-carrier protein] hydrolase activity" EXACT [EC:3.1.2.21]
synonym: "dodecyl-acyl-carrier protein hydrolase" BROAD [EC:3.1.2.21]
synonym: "lauroyl-[acyl-carrier-protein] hydrolase activity" EXACT []
synonym: "lauroyl-ACP hydrolase activity" EXACT []
synonym: "lauryl-[acyl-carrier protein] hydrolase activity" EXACT [EC:3.1.2.21]
synonym: "lauryl-acyl-carrier protein hydrolase activity" EXACT [EC:3.1.2.21]
synonym: "lauryl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.21]
xref: EC:3.1.2.21
xref: MetaCyc:3.1.2.21-RXN
is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity

[Term]
id: GO:0047382
name: methylphosphothioglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + S-methyl-3-phospho-1-thio-D-glycerate = phosphate + S-methyl-1-thio-D-glycerate." [EC:3.1.3.14, MetaCyc:3.1.3.14-RXN]
synonym: "methylthiophosphoglycerate phosphatase activity" EXACT [EC:3.1.3.14]
synonym: "S-methyl-3-phospho-1-thio-D-glycerate phosphohydrolase activity" EXACT [EC:3.1.3.14]
xref: EC:3.1.3.14
xref: MetaCyc:3.1.3.14-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047383
name: guanidinodeoxy-scyllo-inositol-4-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate = phosphate + 1-guanidino-1-deoxy-scyllo-inositol." [EC:3.1.3.40, MetaCyc:3.1.3.40-RXN]
synonym: "1-guanidino-1-deoxy-scyllo-inositol-4-P phosphohydrolase activity" EXACT [EC:3.1.3.40]
synonym: "1-guanidino-1-deoxy-scyllo-inositol-4-phosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.40]
synonym: "1-guanidino-scyllo-inositol 4-phosphatase activity" EXACT [EC:3.1.3.40]
xref: EC:3.1.3.40
xref: MetaCyc:3.1.3.40-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047384
name: [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]." [EC:3.1.3.47, MetaCyc:3.1.3.47-RXN]
synonym: "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphatase activity" EXACT [EC:3.1.3.47]
synonym: "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.47]
synonym: "reductase phosphatase activity" BROAD [EC:3.1.3.47]
xref: EC:3.1.3.47
xref: MetaCyc:3.1.3.47-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047385
name: [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate = phosphate + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]." [EC:3.1.3.52, MetaCyc:3.1.3.52-RXN]
synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphatase activity" EXACT [EC:3.1.3.52]
synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.52]
synonym: "branched-chain 2-keto acid dehydrogenase phosphatase activity" EXACT [EC:3.1.3.52]
synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" BROAD [EC:3.1.3.52]
synonym: "branched-chain oxo-acid dehydrogenase phosphatase activity" RELATED [EC:3.1.3.52]
xref: EC:3.1.3.52
xref: MetaCyc:3.1.3.52-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047386
name: fructose-2,6-bisphosphate 6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + D-fructose 2,6-bisphosphate = phosphate + fructose-2-phosphate." [EC:3.1.3.54, MetaCyc:3.1.3.54-RXN]
synonym: "beta-D-fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54]
synonym: "D-fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54]
synonym: "fructose 2,6-bisphosphate-6-phosphohydrolase activity" EXACT [EC:3.1.3.54]
synonym: "fructose-2,6-bisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.54]
xref: EC:3.1.3.54
xref: MetaCyc:3.1.3.54-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047387
name: serine-ethanolaminephosphate phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + serine phosphoethanolamine = phosphoryl-ethanolamine + L-serine." [EC:3.1.4.13, MetaCyc:3.1.4.13-RXN]
subset: gosubset_prok
synonym: "SEP diesterase activity" EXACT [EC:3.1.4.13]
synonym: "serine ethanolamine phosphodiester phosphodiesterase activity" EXACT [EC:3.1.4.13]
synonym: "serine-phosphoethanolamine ethanolaminephosphohydrolase activity" EXACT [EC:3.1.4.13]
xref: EC:3.1.4.13
xref: MetaCyc:3.1.4.13-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047388
name: adenylyl-[glutamate-ammonia ligase] hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + adenylyl-GS = glutaminesyn-oligomer + AMP." [EC:3.1.4.15, MetaCyc:3.1.4.15-RXN]
synonym: "adenylyl(glutamine synthetase) hydrolase activity" EXACT [EC:3.1.4.15]
synonym: "adenylyl-glutamate-ammonia ligase hydrolase activity" EXACT [EC:3.1.4.15]
synonym: "adenylyl-glutamine-synthetasehydrolase activity" EXACT [EC:3.1.4.15]
synonym: "adenylyl-L-glutamate:ammonia ligase (ADP-forming) adenylylhydrolase activity" EXACT [EC:3.1.4.15]
xref: EC:3.1.4.15
xref: MetaCyc:3.1.4.15-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047389
name: glycerophosphocholine phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline." [EC:3.1.4.2, MetaCyc:3.1.4.2-RXN]
subset: gosubset_prok
synonym: "glycerolphosphorylcholine phosphodiesterase activity" EXACT [EC:3.1.4.2]
synonym: "glycerophosphinicocholine diesterase activity" EXACT [EC:3.1.4.2]
synonym: "glycerophosphohydrolase activity" EXACT [EC:3.1.4.2]
synonym: "glycerylphosphorylcholinediesterase activity" EXACT [EC:3.1.4.2]
synonym: "sn-glycero-3-phosphocholine glycerophosphohydrolase activity" EXACT [EC:3.1.4.2]
synonym: "sn-glycero-3-phosphorylcholine diesterase activity" EXACT [EC:3.1.4.2]
xref: EC:3.1.4.2
xref: MetaCyc:3.1.4.2-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047390
name: glycerophosphocholine cholinephosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = phosphoryl-choline + glycerol." [EC:3.1.4.38, MetaCyc:3.1.4.38-RXN]
synonym: "L-3-glycerylphosphinicocholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.38]
synonym: "sn-glycero-3-phosphocholine cholinephosphohydrolase activity" EXACT [EC:3.1.4.38]
xref: EC:3.1.4.38
xref: MetaCyc:3.1.4.38-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047391
name: alkylglycerophosphoethanolamine phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanol-amine + 1-alkyl-sn-glycerol 3-phosphate." [EC:3.1.4.39, MetaCyc:3.1.4.39-RXN]
synonym: "1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase activity" EXACT [EC:3.1.4.39]
synonym: "lysophospholipase D activity" RELATED [EC:3.1.4.39]
xref: EC:3.1.4.39
xref: MetaCyc:3.1.4.39-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047392
name: CMP-N-acylneuraminate phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP." [EC:3.1.4.40, MetaCyc:3.1.4.40-RXN]
synonym: "CMP-N-acetylneuraminate hydrolase activity" EXACT [EC:3.1.4.40]
synonym: "CMP-N-acylneuraminate N-acylneuraminohydrolase activity" EXACT [EC:3.1.4.40]
synonym: "CMP-N-acylneuraminic acid hydrolase activity" EXACT [EC:3.1.4.40]
synonym: "CMP-sialate hydrolase activity" EXACT [EC:3.1.4.40]
synonym: "CMP-sialic acid hydrolase activity" EXACT [EC:3.1.4.40]
synonym: "cytidine monophosphate-N-acetylneuraminic acid hydrolase activity" EXACT [EC:3.1.4.40]
synonym: "cytidine monophosphosialate hydrolase activity" EXACT [EC:3.1.4.40]
synonym: "cytidine monophosphosialic hydrolase activity" EXACT [EC:3.1.4.40]
xref: EC:3.1.4.40
xref: MetaCyc:3.1.4.40-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047393
name: glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + glycerol 1,2-cyclic phosphate = glycerol-3-phosphate." [EC:3.1.4.42, MetaCyc:3.1.4.42-RXN]
synonym: "rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase activity" EXACT [EC:3.1.4.42]
synonym: "rac-glycerol-1,2-cyclic-phosphate 2-glycerophosphohydrolase activity" EXACT [EC:3.1.4.42]
xref: EC:3.1.4.42
xref: MetaCyc:3.1.4.42-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047394
name: glycerophosphoinositol inositolphosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol." [EC:3.1.4.43, MetaCyc:3.1.4.43-RXN]
subset: gosubset_prok
synonym: "1,2-cyclic-inositol-phosphate phosphodiesterase activity" EXACT []
synonym: "1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase activity" EXACT [EC:3.1.4.43]
synonym: "1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity" EXACT [EC:3.1.4.43]
synonym: "D-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43]
synonym: "D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43]
synonym: "D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase activity" EXACT [EC:3.1.4.43]
synonym: "inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity" EXACT [EC:3.1.4.43]
xref: EC:3.1.4.43
xref: MetaCyc:3.1.4.43-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047395
name: glycerophosphoinositol glycerophosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + sn-glycero-3-phospho-1-inositol = glycerol-3-phosphate + inositol." [EC:3.1.4.44, MetaCyc:3.1.4.44-RXN]
synonym: "1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44]
synonym: "sn-glycero(3)phosphoinositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44]
synonym: "sn-glycero-3-phospho-1-inositol glycerophosphohydrolase activity" EXACT [EC:3.1.4.44]
xref: EC:3.1.4.44
xref: MetaCyc:3.1.4.44-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047396
name: glycosylphosphatidylinositol diacylglycerol-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate." [EC:4.6.1.14, MetaCyc:3.1.4.47-RXN]
subset: gosubset_prok
synonym: "(glycosyl)phosphatidylinositol-specific phospholipase C activity" EXACT [EC:4.6.1.14]
synonym: "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]" RELATED [EC:4.6.1.14]
synonym: "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) activity" EXACT [EC:4.6.1.14]
synonym: "glycosyl inositol phospholipid anchor-hydrolyzing enzyme activity" EXACT [EC:4.6.1.14]
synonym: "glycosylphosphatidylinositol-phospholipase C activity" NARROW [EC:4.6.1.14]
synonym: "glycosylphosphatidylinositol-specific phospholipase C activity" EXACT [EC:4.6.1.14]
synonym: "GPI-PLC activity" EXACT [EC:4.6.1.14]
synonym: "GPI-specific phospholipase C activity" EXACT [EC:4.6.1.14]
synonym: "variant-surface-glycoprotein phospholipase C activity" EXACT []
synonym: "VSG-lipase activity" EXACT [EC:4.6.1.14]
xref: EC:4.6.1.14
xref: MetaCyc:3.1.4.47-RXN
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0047397
name: dolichylphosphate-glucose phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose." [EC:3.1.4.48, MetaCyc:3.1.4.48-RXN]
synonym: "Dol-P-Glc phosphodiesterase activity" EXACT [EC:3.1.4.48]
synonym: "dolichol phosphoglucose phosphodiesterase activity" EXACT [EC:3.1.4.48]
synonym: "dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase activity" EXACT [EC:3.1.4.48]
synonym: "dolichyl-phosphate-glucose phosphodiesterase activity" EXACT []
xref: EC:3.1.4.48
xref: MetaCyc:3.1.4.48-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047398
name: dolichylphosphate-mannose phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose." [EC:3.1.4.49, MetaCyc:3.1.4.49-RXN]
synonym: "dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase activity" EXACT [EC:3.1.4.49]
synonym: "mannosylphosphodolichol phosphodiesterase activity" EXACT [EC:3.1.4.49]
xref: EC:3.1.4.49
xref: MetaCyc:3.1.4.49-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047399
name: glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate." [EC:3.1.4.51, MetaCyc:3.1.4.51-RXN]
synonym: "6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrolase activity" EXACT [EC:3.1.4.51]
synonym: "alpha-glucose-1-phosphate phosphodiesterase activity" EXACT [EC:3.1.4.51]
xref: EC:3.1.4.51
xref: MetaCyc:3.1.4.51-RXN
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0047400
name: phosphonoacetate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + phosphonoacetate = phosphate + acetate." [EC:3.11.1.2, MetaCyc:3.11.1.2-RXN]
synonym: "phosphonoacetate phosphonohydrolase activity" EXACT [EC:3.11.1.2]
xref: EC:3.11.1.2
xref: MetaCyc:3.11.1.2-RXN
is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds

[Term]
id: GO:0047401
name: trithionate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + trithionate = 2 H+ + SO4(2-) (sulfate) + S2O3(2-)." [EC:3.12.1.1, MetaCyc:3.12.1.1-RXN]
synonym: "trithionate thiosulfohydrolase activity" EXACT [EC:3.12.1.1]
xref: EC:3.12.1.1
xref: MetaCyc:3.12.1.1-RXN
is_a: GO:0016828 ! hydrolase activity, acting on acid sulfur-sulfur bonds

[Term]
id: GO:0047402
name: protein-glucosylgalactosylhydroxylysine glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose." [EC:3.2.1.107, MetaCyc:3.2.1.107-RXN]
synonym: "2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-lysine glucohydrolase activity" EXACT [EC:3.2.1.107]
synonym: "protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase activity" EXACT [EC:3.2.1.107]
xref: EC:3.2.1.107
xref: MetaCyc:3.2.1.107-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047403
name: lacto-N-biosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc." [EC:3.2.1.140, MetaCyc:3.2.1.140-RXN]
synonym: "oligosaccharide lacto-N-biosylhydrolase activity" RELATED [EC:3.2.1.140]
xref: EC:3.2.1.140
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047404
name: glucuronosyl-disulfoglucosamine glucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2-,6-disulfo-D-glucosamine." [EC:3.2.1.56, MetaCyc:3.2.1.56-RXN]
synonym: "3-D-glucuronsyl-2-N,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" EXACT [EC:3.2.1.56]
synonym: "3-D-glucuronsyl-N2,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" EXACT [EC:3.2.1.56]
synonym: "glucuronosyl-disulphoglucosamine glucuronidase activity" EXACT []
xref: EC:3.2.1.56
xref: MetaCyc:3.2.1.56-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047405
name: pyrimidine-5'-nucleotide nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine." [EC:3.2.2.10, MetaCyc:3.2.2.10-RXN]
synonym: "Pyr5N activity" EXACT [EC:3.2.2.10]
synonym: "pyrimidine nucleotide N-ribosidase activity" EXACT [EC:3.2.2.10]
synonym: "pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase activity" EXACT [EC:3.2.2.10]
xref: EC:3.2.2.10
xref: MetaCyc:3.2.2.10-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047406
name: beta-aspartyl-N-acetylglucosaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 1-beta-aspartyl-N-acetyl-D-glucosaminylamine = L-asparagine + N-acetyl-D-glucosamine." [EC:3.2.2.11, MetaCyc:3.2.2.11-RXN]
synonym: "1-beta-aspartyl-N-acetyl-D-glucosaminylamine L-asparaginohydrolase activity" EXACT [EC:3.2.2.11]
synonym: "beta-aspartylacetylglucosaminidase activity" EXACT [EC:3.2.2.11]
xref: EC:3.2.2.11
xref: MetaCyc:3.2.2.11-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047407
name: ADP-ribosyl-[dinitrogen reductase] hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]." [EC:3.2.2.24, MetaCyc:3.2.2.24-RXN]
subset: gosubset_prok
synonym: "ADP-D-ribosyl-dinitrogen reductase ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.24]
synonym: "ADP-ribosyl glycohydrolase activity" EXACT [EC:3.2.2.24]
synonym: "ADP-ribosyl-dinitrogen reductase hydrolase activity" EXACT [EC:3.2.2.24]
synonym: "azoferredoxin glycosidase activity" EXACT [EC:3.2.2.24]
synonym: "azoferredoxin-activating enzymes" RELATED [EC:3.2.2.24]
synonym: "dinitrogenase reductase activating glycohydrolase activity" RELATED [EC:3.2.2.24]
synonym: "dinitrogenase reductase-activating glycohydrolase activity" EXACT [EC:3.2.2.24]
xref: EC:3.2.2.24
xref: MetaCyc:3.2.2.24-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047408
name: alkenylglycerophosphocholine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde." [EC:3.3.2.2, MetaCyc:3.3.2.2-RXN]
synonym: "1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase activity" EXACT [EC:3.3.2.2]
synonym: "lysoplasmalogenase activity" EXACT [EC:3.3.2.2]
xref: EC:3.3.2.2
xref: MetaCyc:3.3.2.2-RXN
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0047409
name: alkenylglycerophosphoethanolamine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde." [EC:3.3.2.5, MetaCyc:3.3.2.5-RXN]
synonym: "1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine aldehydohydrolase activity" EXACT [EC:3.3.2.5]
xref: EC:3.3.2.5
xref: MetaCyc:3.3.2.5-RXN
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0047410
name: N-formylmethionylaminoacyl-tRNA deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + charged-fMet-tRNAs = L-methionylaminoacyl-tRNA + formate." [EC:3.5.1.27, MetaCyc:3.5.1.27-RXN]
synonym: "N-formyl-L-methionylaminoacyl-tRNA amidohydrolase activity" EXACT [EC:3.5.1.27]
xref: EC:3.5.1.27
xref: MetaCyc:3.5.1.27-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047411
name: 2-(acetamidomethylene)succinate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate." [EC:3.5.1.29, MetaCyc:3.5.1.29-RXN]
synonym: "2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)" EXACT [EC:3.5.1.29]
synonym: "alpha-(N-acetylaminomethylene)succinic acid hydrolase activity" EXACT [EC:3.5.1.29]
xref: EC:3.5.1.29
xref: MetaCyc:3.5.1.29-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047412
name: N-(long-chain-acyl)ethanolamine deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanol-amine + a fatty acid." [EC:3.5.1.60, MetaCyc:3.5.1.60-RXN]
synonym: "acylethanolamine amidase activity" EXACT []
synonym: "N-(long-chain-acyl)ethanolamine amidohydrolase activity" EXACT []
synonym: "N-acylethanolamine amidohydrolase activity" EXACT []
xref: EC:3.5.1.60
xref: MetaCyc:3.5.1.60-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047413
name: N(alpha)-benzyloxycarbonylleucine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N(alpha)-benzyloxycarbonyl-L-leucine = L-leucine + CO2 + benzyl alcohol." [EC:3.5.1.64, MetaCyc:3.5.1.64-RXN]
synonym: "alpha-N-benzyloxycarbonyl-L-leucine urethanehydrolase activity" EXACT [EC:3.5.1.64]
synonym: "benzyloxycarbonylleucine hydrolase activity" EXACT [EC:3.5.1.64]
synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase IV" RELATED [EC:3.5.1.64]
synonym: "nalpha-benzyloxycarbonyl-L-leucine urethanehydrolase activity" EXACT [EC:3.5.1.64]
synonym: "nalpha-benzyloxycarbonylleucine hydrolase activity" EXACT [EC:3.5.1.64]
xref: EC:3.5.1.64
xref: MetaCyc:3.5.1.64-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047414
name: 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O + 2-(hydroxymethyl)-3-(acetamidomethylene)succinate = CO2 + NH3 + 2-(hydroxymethyl)-4-oxobutanoate + acetate." [EC:3.5.1.66, MetaCyc:3.5.1.66-RXN]
synonym: "2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)" EXACT [EC:3.5.1.66]
synonym: "alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid hydrolase activity" EXACT [EC:3.5.1.66]
synonym: "compound B hydrolase activity" EXACT [EC:3.5.1.66]
xref: EC:3.5.1.66
xref: MetaCyc:3.5.1.66-RXN
xref: Wikipedia:2-(hydroxymethyl)-3-(acetamidomethylene)succinate_amidohydrolase_(deaminating\,_decarboxylating)
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047415
name: D-benzoylarginine-4-nitroanilide amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-benzoyl-D-arginine-4-nitroanilide = N-benzoyl-D-arginine + 4-nitroaniline." [EC:3.5.1.72, MetaCyc:3.5.1.72-RXN]
synonym: "benzoyl-D-arginine arylamidase activity" EXACT [EC:3.5.1.72]
synonym: "D-BAPA-ase activity" EXACT [EC:3.5.1.72]
synonym: "N-benzoyl-D-arginine-4-nitroanilide amidohydrolase activity" EXACT [EC:3.5.1.72]
xref: EC:3.5.1.72
xref: MetaCyc:3.5.1.72-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047416
name: arylalkyl acylamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine." [EC:3.5.1.76, MetaCyc:3.5.1.76-RXN]
subset: gosubset_prok
synonym: "aralkyl acylamidase activity" EXACT [EC:3.5.1.76]
synonym: "N-acetylarylalkylamine amidohydrolase activity" EXACT [EC:3.5.1.76]
xref: EC:3.5.1.76
xref: MetaCyc:3.5.1.76-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047417
name: N-carbamoyl-D-amino acid hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid." [EC:3.5.1.77, MetaCyc:3.5.1.77-RXN]
subset: gosubset_prok
synonym: "N-carbamoyl-D-amino acid amidohydrolase activity" EXACT [EC:3.5.1.77]
xref: EC:3.5.1.77
xref: MetaCyc:3.5.1.77-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047418
name: phthalyl amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine." [EC:3.5.1.79, MetaCyc:3.5.1.79-RXN]
synonym: "o-phthalyl amidase activity" NARROW [EC:3.5.1.79]
synonym: "phthalyl-amide amidohydrolase activity" EXACT [EC:3.5.1.79]
xref: EC:3.5.1.79
xref: MetaCyc:3.5.1.79-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047419
name: N-acetylgalactosamine-6-phosphate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate." [EC:3.5.1.-, MetaCyc:3.5.1.80-RXN]
xref: EC:3.5.1.-
xref: MetaCyc:3.5.1.80-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047420
name: N-acyl-D-amino-acid deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid." [EC:3.5.1.81, MetaCyc:3.5.1.81-RXN]
subset: gosubset_prok
synonym: "D-aminoacylase activity" EXACT [EC:3.5.1.81]
synonym: "N-acyl-D-amino acid amidohydrolase activity" EXACT [EC:3.5.1.81]
xref: EC:3.5.1.81
xref: MetaCyc:3.5.1.81-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047421
name: N-acyl-D-glutamate deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acyl-D-glutamate = D-glutamate + carboxylate." [EC:3.5.1.82, MetaCyc:3.5.1.82-RXN]
subset: gosubset_prok
synonym: "N-acyl-D-glutamate amidohydrolase activity" EXACT [EC:3.5.1.82]
xref: EC:3.5.1.82
xref: MetaCyc:3.5.1.82-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047422
name: N-acyl-D-aspartate deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-acyl-D-aspartate = D-aspartate + carboxylate." [EC:3.5.1.83, MetaCyc:3.5.1.83-RXN]
subset: gosubset_prok
synonym: "N-acyl-D-aspartate amidohydrolase activity" EXACT [EC:3.5.1.83]
xref: EC:3.5.1.83
xref: MetaCyc:3.5.1.83-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047423
name: N-methylhydantoinase (ATP-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O + N-methylhydantoin + ATP = phosphate + N-carbamoylsarcosine + ADP." [EC:3.5.2.14, MetaCyc:3.5.2.14-RXN]
subset: gosubset_prok
synonym: "methylhydantoin amidase activity" EXACT [EC:3.5.2.14]
synonym: "N-methylhydantoin amidohydrolase activity" EXACT [EC:3.5.2.14]
synonym: "N-methylhydantoin hydrolase activity" EXACT [EC:3.5.2.14]
synonym: "N-methylhydantoinase (ATP-hydrolysing)" EXACT [EC:3.5.2.14]
synonym: "N-methylhydantoinase activity" EXACT [EC:3.5.2.14]
synonym: "N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing)" EXACT [EC:3.5.2.14]
xref: EC:3.5.2.14
xref: MetaCyc:3.5.2.14-RXN
xref: Wikipedia:N-methylhydantoinase_(ATP-hydrolysing)
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0047424
name: methylenediurea deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O + NH(2)-CO-NH-CH(2)-NH-CO-NH(2) = CO2 + 2 NH3 + N-hydroxymethylurea." [EC:3.5.3.21, MetaCyc:3.5.3.21-RXN]
subset: gosubset_prok
synonym: "methylenediurea aminohydrolase activity" EXACT [EC:3.5.3.21]
synonym: "methylenediurease activity" EXACT [EC:3.5.3.21]
xref: EC:3.5.3.21
xref: MetaCyc:3.5.3.21-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047425
name: 1-pyrroline-4-hydroxy-2-carboxylate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 1-pyrroline-4-hydroxy-2-carboxylate = NH3 + 2,5-dioxopentanoate." [EC:3.5.4.22, MetaCyc:3.5.4.22-RXN]
synonym: "1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)" EXACT [EC:3.5.4.22]
synonym: "HPC deaminase activity" EXACT [EC:3.5.4.22]
xref: EC:3.5.4.22
xref: MetaCyc:3.5.4.22-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047426
name: ricinine nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone." [EC:3.5.5.2, MetaCyc:3.5.5.2-RXN]
synonym: "ricinine aminohydrolase activity" EXACT [EC:3.5.5.2]
xref: EC:3.5.5.2
xref: MetaCyc:3.5.5.2-RXN
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0047427
name: cyanoalanine nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O + 3-cyano-L-alanine = NH3 + L-aspartate." [EC:3.5.5.4, MetaCyc:3.5.5.4-RXN]
synonym: "3-cyano-L-alanine aminohydrolase activity" EXACT [EC:3.5.5.4]
synonym: "beta-cyanoalanine nitrilase activity" EXACT [EC:3.5.5.4]
xref: EC:3.5.5.4
xref: MetaCyc:3.5.5.4-RXN
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0047428
name: arylacetonitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3." [EC:3.5.5.5, MetaCyc:3.5.5.5-RXN]
synonym: "arylacetonitrile aminohydrolase activity" EXACT [EC:3.5.5.5]
xref: EC:3.5.5.5
xref: MetaCyc:3.5.5.5-RXN
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0047429
name: nucleoside-triphosphate diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a nucleoside triphosphate = pyrophosphate + a nucleotide." [EC:3.6.1.19, MetaCyc:3.6.1.19-RXN]
subset: gosubset_prok
synonym: "nucleoside-triphosphate diphosphohydrolase activity" EXACT [EC:3.6.1.19]
synonym: "nucleoside-triphosphate pyrophosphatase activity" EXACT []
xref: EC:3.6.1.19
xref: MetaCyc:3.6.1.19-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047430
name: oligosaccharide-diphosphodolichol diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate." [EC:3.6.1.44, MetaCyc:3.6.1.44-RXN]
synonym: "oligosaccharide-diphosphodolichol phosphodolichohydrolase activity" EXACT [EC:3.6.1.44]
synonym: "oligosaccharide-diphosphodolichol pyrophosphatase activity" EXACT []
xref: EC:3.6.1.44
xref: MetaCyc:3.6.1.44-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047431
name: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate = CO2 + 3-hydroxy-2-methylpyridine-5-carboxylate." [EC:4.1.1.51, MetaCyc:4.1.1.51-RXN]
synonym: "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase (3-hydroxy-2-methylpyridine-5-carboxylate-forming)" EXACT [EC:4.1.1.51]
synonym: "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase activity" EXACT [EC:4.1.1.51]
xref: EC:4.1.1.51
xref: MetaCyc:4.1.1.51-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047432
name: 2,2-dialkylglycine decarboxylase (pyruvate) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,2-dialkylglycine + pyruvate = dialkyl ketone + L-alanine + CO2." [EC:4.1.1.64, MetaCyc:4.1.1.64-RXN]
subset: gosubset_prok
synonym: "2,2-dialkyl-2-amino acid-pyruvate aminotransferase activity" EXACT [EC:4.1.1.64]
synonym: "2,2-dialkylglycine carboxy-lyase (amino-transferring)" EXACT [EC:4.1.1.64]
synonym: "2,2-dialkylglycine carboxy-lyase (amino-transferring; L-alanine-forming)" EXACT [EC:4.1.1.64]
synonym: "alpha-dialkyl amino acid transaminase activity" EXACT [EC:4.1.1.64]
synonym: "dialkyl amino acid (pyruvate) decarboxylase activity" EXACT [EC:4.1.1.64]
synonym: "dialkylamino-acid decarboxylase (pyruvate)" EXACT [EC:4.1.1.64]
synonym: "L-alanine-alpha-ketobutyrate aminotransferase activity" EXACT [EC:4.1.1.64]
xref: EC:4.1.1.64
xref: MetaCyc:4.1.1.64-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047433
name: branched-chain-2-oxoacid decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S)-3-methyl-2-oxopentanoate = 2-methylbutanal + CO2." [EC:4.1.1.72, MetaCyc:4.1.1.72-RXN]
synonym: "(3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)" EXACT [EC:4.1.1.72]
synonym: "(3S)-3-methyl-2-oxopentanoate carboxy-lyase activity" EXACT [EC:4.1.1.72]
synonym: "BCKA" RELATED [EC:4.1.1.72]
synonym: "branched-chain alpha-keto acid decarboxylase activity" EXACT [EC:4.1.1.72]
synonym: "branched-chain keto acid decarboxylase activity" EXACT [EC:4.1.1.72]
synonym: "branched-chain oxo acid decarboxylase activity" EXACT [EC:4.1.1.72]
xref: EC:4.1.1.72
xref: MetaCyc:4.1.1.72-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047434
name: indolepyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde." [EC:4.1.1.74, MetaCyc:4.1.1.74-RXN]
subset: gosubset_prok
synonym: "3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]" RELATED [EC:4.1.1.74]
synonym: "3-(indol-3-yl)pyruvate carboxy-lyase activity" EXACT [EC:4.1.1.74]
synonym: "indol-3-yl-pyruvate carboxy-lyase activity" EXACT [EC:4.1.1.74]
synonym: "indole-3-pyruvate decarboxylase activity" EXACT [EC:4.1.1.74]
xref: EC:4.1.1.74
xref: MetaCyc:4.1.1.74-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047435
name: 5-guanidino-2-oxopentanoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-guanidino-2-oxo-pentanoate = CO2 + 4-guanidinobutanoate." [EC:4.1.1.75, MetaCyc:4.1.1.75-RXN]
synonym: "2-oxo-5-guanidinopentanoate carboxy-lyase (4-guanidinobutanal-forming)" EXACT [EC:4.1.1.75]
synonym: "2-oxo-5-guanidinopentanoate carboxy-lyase activity" EXACT [EC:4.1.1.75]
synonym: "2-oxo-5-guanidinopentanoate decarboxylase activity" EXACT [EC:4.1.1.75]
synonym: "2-oxo-5-guanidinovalerate alpha-ketoarginine decarboxylase activity" EXACT [EC:4.1.1.75]
synonym: "alpha-ketoarginine decarboxylase activity" EXACT [EC:4.1.1.75]
xref: EC:4.1.1.75
xref: MetaCyc:4.1.1.75-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047436
name: arylmalonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-aryl-2-methylmalonate = CO2 + 2-arylpropionate." [EC:4.1.1.76, MetaCyc:4.1.1.76-RXN]
subset: gosubset_prok
synonym: "2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming)" EXACT [EC:4.1.1.76]
synonym: "2-aryl-2-methylmalonate carboxy-lyase activity" EXACT [EC:4.1.1.76]
synonym: "AMDASE" RELATED [EC:4.1.1.76]
synonym: "AMDase activity" EXACT [EC:4.1.1.76]
xref: EC:4.1.1.76
xref: MetaCyc:4.1.1.76-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047437
name: 4-oxalocrotonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate." [EC:4.1.1.77, MetaCyc:4.1.1.77-RXN]
subset: gosubset_prok
synonym: "4-oxalocrotonate carboxy-lyase (2-oxopent-4-enoate-forming)" EXACT [EC:4.1.1.77]
synonym: "4-oxalocrotonate carboxy-lyase activity" EXACT [EC:4.1.1.77]
xref: EC:4.1.1.77
xref: MetaCyc:4.1.1.77-RXN
xref: UM-BBD_enzymeID:e0905
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047438
name: 2-dehydro-3-deoxy-L-pentonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-L-pentonate = glycolaldehyde + pyruvate." [EC:4.1.2.18, MetaCyc:4.1.2.18-RXN]
synonym: "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.18]
synonym: "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase activity" EXACT [EC:4.1.2.18]
synonym: "2-keto-3-deoxy-D-xylonate aldolase activity" EXACT [EC:4.1.2.18]
synonym: "2-keto-3-deoxy-L-arabonate aldolase activity" NARROW [EC:4.1.2.18]
synonym: "2-keto-3-deoxy-L-pentonate aldolase activity" EXACT [EC:4.1.2.18]
synonym: "3-deoxy-D-pentulosonic acid aldolase" BROAD [EC:4.1.2.18]
xref: EC:4.1.2.18
xref: MetaCyc:4.1.2.18-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047439
name: 3-deoxy-D-manno-octulosonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate." [EC:4.1.2.23, MetaCyc:4.1.2.23-RXN]
synonym: "2-keto-3-deoxyoctonate aldolase activity" EXACT [EC:4.1.2.23]
synonym: "2-keto-3-deoxyoctonic aldolase activity" EXACT [EC:4.1.2.23]
synonym: "3-deoxy-D-manno-octulosonate D-arabinose-lyase (pyruvate-forming)" EXACT [EC:4.1.2.23]
synonym: "3-deoxy-D-manno-octulosonate D-arabinose-lyase activity" EXACT [EC:4.1.2.23]
synonym: "3-deoxy-D-manno-octulosonic aldolase activity" EXACT [EC:4.1.2.23]
synonym: "3-deoxyoctulosonic aldolase activity" EXACT [EC:4.1.2.23]
synonym: "KDOaldolase activity" EXACT [EC:4.1.2.23]
xref: EC:4.1.2.23
xref: MetaCyc:4.1.2.23-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047440
name: 2-dehydro-3-deoxy-D-pentonate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-pentonate = glycolaldehyde + pyruvate." [EC:4.1.2.28, MetaCyc:4.1.2.28-RXN]
synonym: "2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase activity" EXACT [EC:4.1.2.28]
synonym: "2-keto-3-deoxy-D-pentonate aldolase activity" EXACT [EC:4.1.2.28]
synonym: "3-deoxy-D-pentulosonic acid aldolase" BROAD [EC:4.1.2.28]
xref: EC:4.1.2.28
xref: MetaCyc:4.1.2.28-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047441
name: 5-dehydro-2-deoxyphosphogluconate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-dehydro-2-deoxy-D-gluconate 6-phosphate = malonate semialdehyde + dihydroxy-acetone-phosphate." [EC:4.1.2.29, MetaCyc:4.1.2.29-RXN]
synonym: "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.29]
synonym: "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase activity" EXACT [EC:4.1.2.29]
synonym: "phospho-5-dehydro-2-deoxygluconate aldolase activity" EXACT [EC:4.1.2.29]
synonym: "phospho-5-keto-2-deoxygluconate aldolase activity" EXACT [EC:4.1.2.29]
xref: EC:4.1.2.29
xref: MetaCyc:4.1.2.29-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047442
name: 17-alpha-hydroxyprogesterone aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione." [EC:4.1.2.30, MetaCyc:4.1.2.30-RXN]
synonym: "17-alpha-hydroxyprogesterone acetaldehyde-lyase activity" EXACT [EC:4.1.2.30]
synonym: "17alpha-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming)" EXACT [EC:4.1.2.30]
synonym: "17alpha-hydroxyprogesterone acetaldehyde-lyase activity" EXACT [EC:4.1.2.30]
synonym: "17alpha-hydroxyprogesterone aldolase activity" EXACT [EC:4.1.2.30]
synonym: "C-17/C-20 lyase activity" EXACT [EC:4.1.2.30]
xref: EC:4.1.2.30
xref: MetaCyc:4.1.2.30-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047443
name: 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate." [EC:4.1.3.17, MetaCyc:4.1.3.17-RXN]
subset: gosubset_prok
synonym: "4-hydroxy-4-methyl-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.17]
synonym: "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)" EXACT [EC:4.1.3.17]
synonym: "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase activity" EXACT [EC:4.1.3.17]
synonym: "gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase activity" EXACT [EC:4.1.3.17]
synonym: "pyruvate aldolase activity" EXACT [EC:4.1.3.17]
xref: EC:4.1.3.17
xref: MetaCyc:4.1.3.17-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047444
name: N-acylneuraminate-9-phosphate synthase activity
namespace: molecular_function
alt_id: GO:0019007
def: "Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate." [EC:2.5.1.57, MetaCyc:4.1.3.20-RXN]
synonym: "N-acetylneuraminate 9-phosphate lyase activity" EXACT [EC:2.5.1.57]
synonym: "N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase activity" EXACT [EC:2.5.1.57]
synonym: "N-acetylneuraminate 9-phosphate synthetase activity" EXACT [EC:2.5.1.57]
synonym: "N-acetylneuraminic acid phosphate synthase activity" EXACT [GOC:mah]
synonym: "N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.57]
synonym: "phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase activity" EXACT [EC:2.5.1.57]
synonym: "sialic acid 9-phosphate synthetase activity" EXACT [EC:2.5.1.57]
xref: EC:2.5.1.57
xref: MetaCyc:4.1.3.20-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047445
name: 3-hydroxy-3-isohexenylglutaryl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = acetate + 7-methyl-3-oxooctanoyl-CoA." [EC:4.1.3.26, MetaCyc:4.1.3.26-RXN]
synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)" EXACT [EC:4.1.3.26]
synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase activity" EXACT [EC:4.1.3.26]
synonym: "3-hydroxy-3-isohexenylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.26]
synonym: "3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase activity" EXACT [EC:4.1.3.26]
synonym: "beta-hydroxy-beta-isohexenylglutaryl CoA-lyase activity" EXACT [EC:4.1.3.26]
synonym: "hydroxyisohexenylglutaryl-CoA:acetatelyase activity" EXACT [EC:4.1.3.26]
xref: EC:4.1.3.26
xref: MetaCyc:4.1.3.26-RXN
xref: UM-BBD_enzymeID:e0723
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047446
name: (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = cyclohexanone + acetyl-CoA." [EC:4.1.3.35, MetaCyc:4.1.3.35-RXN]
synonym: "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.35]
synonym: "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase activity" EXACT [EC:4.1.3.35]
xref: EC:4.1.3.35
xref: MetaCyc:4.1.3.35-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047447
name: erythro-3-hydroxyaspartate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid." [EC:4.3.1.20, MetaCyc:4.3.1.20-RXN]
synonym: "3-hydroxyaspartate dehydratase activity" BROAD [EC:4.3.1.20]
synonym: "erythro-3-hydroxy-L(s)-aspartate hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.20]
synonym: "erythro-3-hydroxy-Ls-aspartate ammonia-lyase (oxaloacetate-forming)" EXACT [EC:4.3.1.20]
synonym: "erythro-3-hydroxy-Ls-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.20]
synonym: "erythro-3-hydroxy-Ls-aspartate hydro-lyase (deaminating)" EXACT [EC:4.3.1.20]
synonym: "erythro-3-hydroxyaspartate dehydratase activity" EXACT []
synonym: "erythro-beta-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.20]
xref: EC:4.3.1.20
xref: MetaCyc:4.3.1.20-RXN
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0047448
name: 5-dehydro-4-deoxyglucarate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-keto-4-deoxy-D-glucarate = CO2 + H2O + 2,5-dioxopentanoate." [EC:4.2.1.41, MetaCyc:4.2.1.41-RXN]
subset: gosubset_prok
synonym: "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.41]
synonym: "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating; 2,5-dioxopentanoate-forming)" EXACT [EC:4.2.1.41]
synonym: "5-keto-4-deoxy-glucarate dehydratase activity" EXACT [EC:4.2.1.41]
synonym: "D-4-deoxy-5-ketoglucarate hydro-lyase activity" EXACT [EC:4.2.1.41]
synonym: "deoxyketoglucarate dehydratase activity" EXACT [EC:4.2.1.41]
xref: EC:4.2.1.41
xref: MetaCyc:4.2.1.41-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047449
name: 2-dehydro-3-deoxy-L-arabinonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = H2O + 2,5-dioxopentanoate." [EC:4.2.1.43, MetaCyc:4.2.1.43-RXN]
synonym: "2-dehydro-3-deoxy-L-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)" EXACT [EC:4.2.1.43]
synonym: "2-dehydro-3-deoxy-L-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.43]
synonym: "2-keto-3-deoxy-L-arabinonate dehydratase activity" EXACT [EC:4.2.1.43]
xref: EC:4.2.1.43
xref: MetaCyc:4.2.1.43-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047450
name: crotonoyl-[acyl-carrier-protein] hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxybutanoyl-[acyl-carrier protein] = H2O + but-2-enoyl-[acyl-carrier protein]." [EC:4.2.1.58, MetaCyc:4.2.1.58-RXN]
synonym: "(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.58]
synonym: "(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase (but-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.58]
synonym: "(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.58]
synonym: "3-hydroxybutyryl acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.58]
synonym: "beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity" EXACT [EC:4.2.1.58]
synonym: "beta-hydroxybutyryl acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.58]
synonym: "crotonoyl-[acyl-carrier protein] hydratase activity" EXACT []
synonym: "crotonoyl-ACP hydratase activity" EXACT []
synonym: "crotonoyl-acyl-carrier-protein hydratase activity" EXACT [EC:4.2.1.58]
synonym: "crotonyl acyl carrier protein hydratase activity" EXACT [EC:4.2.1.58]
synonym: "enoyl acyl carrier protein hydrase activity" EXACT [EC:4.2.1.58]
xref: EC:4.2.1.58
xref: MetaCyc:4.2.1.58-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047451
name: 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]." [EC:4.2.1.59, MetaCyc:4.2.1.59-RXN]
synonym: "(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.59]
synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase (oct-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.59]
synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.59]
synonym: "3-hydroxyoctanoyl-[acyl-carrier protein] dehydratase activity" EXACT []
synonym: "3-hydroxyoctanoyl-ACP dehydratase activity" EXACT []
synonym: "3-hydroxyoctanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.59]
synonym: "beta-hydroxyoctanoyl thioester dehydratase activity" EXACT [EC:4.2.1.59]
synonym: "beta-hydroxyoctanoyl-ACP-dehydrase activity" EXACT [EC:4.2.1.59]
synonym: "beta-hydroxyoctanoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.59]
synonym: "D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase activity" EXACT [EC:4.2.1.59]
synonym: "D-3-hydroxyoctanoyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.59]
xref: EC:4.2.1.59
xref: MetaCyc:4.2.1.59-RXN
is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity

[Term]
id: GO:0047452
name: protoaphin-aglucone dehydratase (cyclizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: protoaphin aglucone = H2O + xanthoaphin." [EC:4.2.1.73, MetaCyc:4.2.1.73-RXN]
synonym: "protoaphin dehydratase (cyclizing)" EXACT [EC:4.2.1.73]
synonym: "protoaphin dehydratase activity" EXACT [EC:4.2.1.73]
synonym: "protoaphin-aglucone hydro-lyase (cyclizing)" EXACT [EC:4.2.1.73]
synonym: "protoaphin-aglucone hydro-lyase (cyclizing; xanthoaphin-forming)" EXACT [EC:4.2.1.73]
xref: EC:4.2.1.73
xref: MetaCyc:4.2.1.73-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047453
name: ATP-dependent NAD(P)H-hydrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide + ATP = phosphate + NADH + ADP." [EC:4.2.1.93, MetaCyc:4.2.1.93-RXN]
synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing)" EXACT [EC:4.2.1.93]
synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ATP-hydrolysing; NADH-forming)" RELATED [EC:4.2.1.93]
synonym: "ATP-dependent H(4)NAD(P)OH dehydratase activity" EXACT []
synonym: "ATP-dependent H4NAD(P)OH dehydratase activity" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide hydrate dehydratase activity" EXACT [EC:4.2.1.93]
xref: EC:4.2.1.93
xref: MetaCyc:4.2.1.93-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047454
name: phaseollidin hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: phaseollidin hydrate = H2O + phaseollidin." [EC:4.2.1.97, MetaCyc:4.2.1.97-RXN]
synonym: "phaseollidin-hydrate hydro-lyase (phaseollidin-forming)" EXACT [EC:4.2.1.97]
synonym: "phaseollidin-hydrate hydro-lyase activity" EXACT [EC:4.2.1.97]
xref: EC:4.2.1.97
xref: MetaCyc:4.2.1.97-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047455
name: 16-alpha-hydroxyprogesterone dehydratase activity
namespace: molecular_function
alt_id: GO:0047523
def: "Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone." [EC:4.2.1.98, MetaCyc:4.2.1.98-RXN]
synonym: "16-alpha-dehydroxylase activity" EXACT [EC:4.2.1.98]
synonym: "16-alpha-hydroxyprogesterone dehydroxylase activity" EXACT [EC:4.2.1.98]
synonym: "16-dehydroprogesterone hydratase activity" RELATED []
synonym: "16alpha-dehydroxylase activity" EXACT [EC:4.2.1.98]
synonym: "16alpha-hydroxyprogesterone dehydratase activity" EXACT [EC:4.2.1.98]
synonym: "16alpha-hydroxyprogesterone dehydroxylase activity" EXACT [EC:4.2.1.98]
synonym: "16alpha-hydroxyprogesterone hydro-lyase (16,17-didehydroprogesterone-forming)" EXACT [EC:4.2.1.98]
synonym: "16alpha-hydroxyprogesterone hydro-lyase activity" EXACT [EC:4.2.1.98]
synonym: "hydroxyprogesterone dehydroxylase activity" EXACT []
xref: EC:4.2.1.98
xref: MetaCyc:4.2.1.98-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047456
name: 2-methylisocitrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylisocitrate = H2O + 2-methylaconitate." [EC:4.2.1.99, MetaCyc:4.2.1.99-RXN]
subset: gosubset_prok
synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]" RELATED [EC:4.2.1.99]
synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.99]
xref: EC:4.2.1.99
xref: MetaCyc:4.2.1.99-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047457
name: exo-(1,4)-alpha-D-glucan lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: linear alpha-glucan = 1,5-anhydro-D-fructose + beta-D-glucose." [EC:4.2.2.13, MetaCyc:4.2.2.13-RXN]
synonym: "(1->4)-alpha-D-glucan exo-4-lyase (1,5-anhydro-D-fructose-forming)" EXACT [EC:4.2.2.13]
synonym: "alpha-(1->4)-glucan 1,5-anhydro-D-fructose eliminase activity" EXACT [EC:4.2.2.13]
synonym: "alpha-1,4-glucan 1,5-anhydro-D-fructose eliminase activity" EXACT [EC:4.2.2.13]
synonym: "alpha-1,4-glucan exo-lyase activity" EXACT [EC:4.2.2.13]
synonym: "alpha-1,4-glucan lyase activity" BROAD [EC:4.2.2.13]
synonym: "exo-(1->4)-alpha-D-glucan lyase activity" EXACT [EC:4.2.2.13]
synonym: "exo-alpha-1,4-glucan lyase activity" EXACT [EC:4.2.2.13]
xref: EC:4.2.2.13
xref: MetaCyc:4.2.2.13-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047458
name: beta-pyrazolylalanine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyrazole + O-acetyl-L-serine = acetate + 3-(pyrazol-1-yl)-L-alanine." [EC:2.5.1.51, MetaCyc:4.2.99.14-RXN]
synonym: "3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.51]
synonym: "beta-(1-pyrazolyl)alanine synthase activity" EXACT [EC:2.5.1.51]
synonym: "beta-pyrazolealanine synthase activity" EXACT [EC:2.5.1.51]
synonym: "beta-pyrazolylalanine synthase (acetylserine) activity" EXACT []
synonym: "BPA-synthase activity" EXACT [EC:2.5.1.51]
synonym: "O(3)-acetyl-L-serine acetate-lyase (adding pyrazole) activity" EXACT [EC:2.5.1.51]
synonym: "O3-acetyl-L-serine acetate-lyase (adding pyrazole)" EXACT [EC:2.5.1.51]
synonym: "O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.51]
synonym: "pyrazolealanine synthase activity" EXACT [EC:2.5.1.51]
synonym: "pyrazolylalaninase activity" EXACT [EC:2.5.1.51]
xref: EC:2.5.1.51
xref: MetaCyc:2.5.1.51-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047459
name: 3-aminobutyryl-CoA ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-3-aminobutyryl-CoA = NH3 + crotonyl-CoA." [EC:4.3.1.14, MetaCyc:4.3.1.14-RXN]
synonym: "L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming)" EXACT [EC:4.3.1.14]
synonym: "L-3-aminobutyryl-CoA ammonia-lyase activity" EXACT [EC:4.3.1.14]
synonym: "L-3-aminobutyryl-CoA deaminase activity" EXACT [EC:4.3.1.14]
xref: EC:4.3.1.14
xref: MetaCyc:4.3.1.14-RXN
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0047460
name: L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-2-amino-4-chloropent-4-enoate = NH3 + HCl + 2-oxopent-4-enoate." [EC:4.5.1.4, MetaCyc:4.5.1.4-RXN]
synonym: "L-2-amino-4-chloro-4-pentenoate dehalogenase activity" EXACT [EC:4.5.1.4]
synonym: "L-2-amino-4-chloropent-4-enoate chloride-lyase (adding H2O; deaminating; 2-oxopent-4-enoate-forming)" EXACT [EC:4.5.1.4]
synonym: "L-2-amino-4-chloropent-4-enoate chloride-lyase (deaminating)" EXACT [EC:4.5.1.4]
xref: EC:4.5.1.4
xref: MetaCyc:4.5.1.4-RXN
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0047461
name: (+)-delta-cadinene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = pyrophosphate + (+)-delta-cadinene." [EC:4.2.3.13, MetaCyc:4.6.1.11-RXN]
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming)" EXACT [EC:4.2.3.13]
synonym: "D-cadinene synthase activity" EXACT [EC:4.2.3.13]
xref: EC:4.2.3.13
xref: MetaCyc:4.6.1.11-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0047462
name: phenylalanine racemase (ATP-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-phenylalanine + ATP = D-phenylalanine + pyrophosphate + AMP." [EC:5.1.1.11, MetaCyc:5.1.1.11-RXN]
subset: gosubset_prok
synonym: "gramicidin S synthetase I" RELATED [EC:5.1.1.11]
synonym: "phenylalanine racemase (adenosine triphosphate-hydrolysing)" EXACT [EC:5.1.1.11]
synonym: "phenylalanine racemase (ATP-hydrolysing)" BROAD [EC:5.1.1.11]
synonym: "phenylalanine racemase activity" EXACT [EC:5.1.1.11]
xref: EC:5.1.1.11
xref: MetaCyc:5.1.1.11-RXN
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0047463
name: 2-aminohexano-6-lactam racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-amino-hexano-6-lactam = D-2-amino-hexano-6-lactam." [EC:5.1.1.15, MetaCyc:5.1.1.15-RXN]
synonym: "2-amino-hexano-6-lactam racemase activity" EXACT [EC:5.1.1.15]
synonym: "alpha-amino-epsilon-caprolactam racemase activity" EXACT [EC:5.1.1.15]
xref: EC:5.1.1.15
xref: MetaCyc:5.1.1.15-RXN
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives

[Term]
id: GO:0047464
name: heparosan-N-sulfate-glucuronate 5-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate." [EC:5.1.3.17, MetaCyc:5.1.3.17-RXN]
synonym: "C-5 uronosyl epimerase activity" EXACT [EC:5.1.3.17]
synonym: "D-glucuronyl C-5 epimerase activity" EXACT [EC:5.1.3.17]
synonym: "heparosan epimerase activity" EXACT [EC:5.1.3.17]
synonym: "heparosan-N-sulfate-D-glucuronosyl 5-epimerase activity" EXACT [EC:5.1.3.17]
synonym: "heparosan-N-sulphate-glucuronate 5-epimerase activity" EXACT []
synonym: "poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase activity" EXACT [EC:5.1.3.17]
synonym: "polyglucuronate epimerase activity" EXACT [EC:5.1.3.17]
xref: EC:5.1.3.17
xref: MetaCyc:5.1.3.17-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047465
name: N-acylglucosamine-6-phosphate 2-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate." [EC:5.1.3.9, MetaCyc:5.1.3.9-RXN]
subset: gosubset_prok
synonym: "acylglucosamine phosphate 2-epimerase activity" EXACT [EC:5.1.3.9]
synonym: "acylglucosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9]
synonym: "acylmannosamine phosphate 2-epimerase activity" EXACT [EC:5.1.3.9]
synonym: "N-acetylglucosmamine 6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9]
synonym: "N-acetylmannosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9]
synonym: "N-acyl-D-glucosamine-6-phosphate 2-epimerase activity" EXACT [EC:5.1.3.9]
xref: EC:5.1.3.9
xref: MetaCyc:5.1.3.9-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047466
name: 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity
namespace: molecular_function
alt_id: GO:0018840
def: "Catalysis of the reaction: cis-2-chloro-4-carboxymmethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymmethylenebut-2-en-1,4-olide." [EC:5.2.1.10, MetaCyc:5.2.1.10-RXN]
synonym: "2-chloro-4-carboxymethylenebut-2-en-1,4-olide cis-trans-isomerase activity" EXACT [EC:5.2.1.10]
synonym: "2-chlorocarboxymethylenebutenolide isomerase activity" EXACT [EC:5.2.1.-]
synonym: "chlorodienelactone isomerase activity" EXACT [EC:5.2.1.-]
xref: EC:5.2.1.-
xref: EC:5.2.1.10
xref: MetaCyc:5.2.1.10-RXN
xref: UM-BBD_enzymeID:e0232
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0047467
name: 4-hydroxyphenylacetaldehyde-oxime isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime." [EC:5.2.1.11, MetaCyc:5.2.1.11-RXN]
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0047468
name: phosphoglucomutase (glucose-cofactor) activity
namespace: molecular_function
def: "Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor." [EC:5.4.2.5, MetaCyc:5.4.2.5-RXN]
synonym: "alpha-D-glucose 1,6-phosphomutase (glucose-cofactor)" EXACT [EC:5.4.2.5]
synonym: "glucose-1-phosphate phosphotransferase activity" EXACT [EC:5.4.2.5]
xref: EC:5.4.2.5
xref: MetaCyc:5.4.2.5-RXN
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0047469
name: 4-carboxymethyl-4-methylbutenolide mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide." [EC:5.4.99.14, MetaCyc:5.4.99.14-RXN]
synonym: "4-carboxymethyl-4-methylbut-2-en-1,4-olide methylmutase activity" EXACT [EC:5.4.99.14]
synonym: "4-methyl-2-enelactone isomerase activity" EXACT [EC:5.4.99.14]
synonym: "4-methyl-2-enelactone methyl-isomerase activity" EXACT [EC:5.4.99.14]
synonym: "4-methyl-3-enelactone methyl isomerase activity" EXACT [EC:5.4.99.14]
synonym: "4-methylmuconolactone methylisomerase activity" EXACT [EC:5.4.99.14]
xref: EC:5.4.99.14
xref: MetaCyc:5.4.99.14-RXN
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047470
name: (1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(1,4-alpha-D-glucosyl)(n-1)-D-glucose = 1-alpha-D-(1,4-alpha-D-glucosyl)(n-1)-alpha-D-glucopyranoside." [EC:5.4.99.15, MetaCyc:5.4.99.15-RXN]
subset: gosubset_prok
synonym: "(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase" BROAD [EC:5.4.99.15]
synonym: "malto-oligosyltrehalose synthase activity" EXACT [EC:5.4.99.15]
synonym: "maltodextrin alpha-D-glucosyltransferase activity" EXACT [EC:5.4.99.15]
xref: EC:5.4.99.15
xref: MetaCyc:5.4.99.15-RXN
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047471
name: maltose alpha-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: maltose = trehalose." [EC:5.4.99.16, MetaCyc:5.4.99.16-RXN]
subset: gosubset_prok
synonym: "maltose alpha-D-glucosylmutase activity" EXACT [EC:5.4.99.16]
synonym: "maltose glucosylmutase activity" EXACT [EC:5.4.99.16]
synonym: "trehalose synthase activity" EXACT [EC:5.4.99.16]
xref: EC:5.4.99.16
xref: MetaCyc:5.4.99.16-RXN
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047472
name: 3-carboxy-cis,cis-muconate cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate." [EC:5.5.1.2, MetaCyc:5.5.1.2-RXN]
subset: gosubset_prok
synonym: "2-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.2]
synonym: "3-carboxymuconate lactonizing enzyme activity" EXACT [EC:5.5.1.2]
synonym: "3-carboxymuconolactone hydrolase activity" EXACT [EC:5.5.1.2]
synonym: "beta-carboxymuconate lactonizing enzyme activity" EXACT [EC:5.5.1.2]
synonym: "CMLE activity" EXACT [EC:5.5.1.2]
xref: EC:5.5.1.2
xref: MetaCyc:5.5.1.2-RXN
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0047473
name: D-alanine-poly(phosphoribitol) ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: poly(ribitol phosphate) + D-alanine + ATP = O-D-alanyl-poly(ribitol phosphate) + pyrophosphate + AMP." [EC:6.1.1.13, MetaCyc:6.1.1.13-RXN]
subset: gosubset_prok
synonym: "D-alanine-activating enzyme activity" RELATED [EC:6.1.1.13]
synonym: "D-alanine-D-alanyl carrier protein ligase activity" EXACT [EC:6.1.1.13]
synonym: "D-alanine-membrane acceptor ligase activity" EXACT [EC:6.1.1.13]
synonym: "D-alanine: membrane acceptor ligase activity" EXACT [EC:6.1.1.13]
synonym: "D-alanine:poly(phosphoribitol) ligase (AMP-forming)" EXACT [EC:6.1.1.13]
synonym: "D-alanyl-poly(phosphoribitol) synthetase activity" EXACT [EC:6.1.1.13]
xref: EC:6.1.1.13
xref: MetaCyc:6.1.1.13-RXN
is_a: GO:0016876 ! ligase activity, forming aminoacyl-tRNA and related compounds

[Term]
id: GO:0047474
name: long-chain-fatty-acid-luciferin-component ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + pyrophosphate + AMP." [EC:6.2.1.19, MetaCyc:6.2.1.19-RXN]
subset: gosubset_prok
synonym: "acyl-protein synthetase activity" RELATED [EC:6.2.1.19]
synonym: "long-chain-fatty-acid:protein ligase (AMP-forming)" EXACT [EC:6.2.1.19]
xref: EC:6.2.1.19
xref: MetaCyc:6.2.1.19-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047475
name: phenylacetate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + phenylacetate + ATP = phenylacetyl-CoA + products of ATP breakdown." [EC:6.2.1.30, MetaCyc:6.2.1.21-RXN]
subset: gosubset_prok
synonym: "PA-CoA ligase activity" EXACT [EC:6.2.1.30]
synonym: "phenacyl coenzyme A synthetase activity" EXACT [EC:6.2.1.30]
synonym: "phenylacetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.30]
synonym: "phenylacetyl-CoA ligase (AMP-forming)" EXACT [EC:6.2.1.30]
synonym: "phenylacetyl-CoA ligase activity" EXACT [EC:6.2.1.30]
xref: EC:6.2.1.30
xref: MetaCyc:PHENYLACETATE--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047476
name: 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + pyrophosphate + AMP." [EC:6.2.1.28, MetaCyc:6.2.1.28-RXN]
synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanate-CoA ligase activity" EXACT [EC:6.2.1.28]
synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.28]
synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.28]
synonym: "DHCA-CoA ligase activity" EXACT [EC:6.2.1.28]
xref: EC:6.2.1.28
xref: MetaCyc:6.2.1.28-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047478
name: aspartate-ammonia ligase (ADP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: NH3 + L-aspartate + ATP = phosphate + L-asparagine + ADP." [EC:6.3.1.4, MetaCyc:6.3.1.4-RXN]
synonym: "asparagine synthetase (adenosine diphosphate-forming)" EXACT [EC:6.3.1.4]
synonym: "asparagine synthetase (ADP-forming) activity" EXACT [EC:6.3.1.4]
synonym: "L-aspartate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.4]
xref: EC:6.3.1.4
xref: MetaCyc:6.3.1.4-RXN
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0047479
name: trypanothione synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate." [EC:6.3.1.9, MetaCyc:6.3.1.9-RXN]
synonym: "glutathionylspermidine:glutathione ligase (ADP-forming)" EXACT [EC:6.3.1.9]
synonym: "TSR synthetase activity" EXACT [EC:6.3.1.9]
xref: EC:6.3.1.9
xref: MetaCyc:6.3.1.9-RXN
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0047480
name: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP." [EC:6.3.2.10, MetaCyc:6.3.2.10-RXN]
comment: Note that the enzyme UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase also has UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity (GO:0008766).
subset: gosubset_prok
synonym: "MurF synthetase activity" RELATED [EC:6.3.2.10]
synonym: "UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase activity" EXACT [EC:6.3.2.10]
synonym: "UDP-MurNAc-pentapeptide synthetase activity" EXACT [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:D-alanyl-D-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity" EXACT []
synonym: "UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity" EXACT [EC:6.3.2.10]
synonym: "UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase activity" EXACT []
synonym: "UDPacetylmuramoylpentapeptide synthetase activity" EXACT [EC:6.3.2.10]
synonym: "uridine diphosphoacetylmuramoylpentapeptide synthetase activity" EXACT [EC:6.3.2.10]
xref: EC:6.3.2.10
xref: MetaCyc:6.3.2.10-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047481
name: D-alanine-alanyl-poly(glycerolphosphate) ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP." [EC:6.3.2.16, MetaCyc:6.3.2.16-RXN]
synonym: "D-alanine-membrane acceptor-ligase activity" EXACT [EC:6.3.2.16]
synonym: "D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming)" EXACT [EC:6.3.2.16]
synonym: "D-alanine:membrane-acceptor ligase activity" EXACT [EC:6.3.2.16]
synonym: "D-alanyl-alanyl-poly(glycerolphosphate) synthetase activity" EXACT [EC:6.3.2.16]
synonym: "D-alanyl-poly(phosphoglycerol) synthetase activity" EXACT [EC:6.3.2.16]
synonym: "D-alanylalanylpoly(phosphoglycerol) synthetase activity" EXACT [EC:6.3.2.16]
xref: EC:6.3.2.16
xref: MetaCyc:6.3.2.16-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047482
name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-lysine + ATP = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ADP." [EC:6.3.2.7, MetaCyc:6.3.2.7-RXN]
subset: gosubset_prok
synonym: "L-lysine-adding enzyme activity" RELATED [EC:6.3.2.7]
synonym: "MurE synthetase activity" RELATED [EC:6.3.2.7]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.7]
synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase activity" EXACT [EC:6.3.2.7]
synonym: "UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase activity" EXACT [EC:6.3.2.7]
synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase activity" EXACT [EC:6.3.2.7]
xref: EC:6.3.2.7
xref: MetaCyc:6.3.2.7-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047483
name: imidazoleacetate-phosphoribosyldiphosphate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-phosphoribosyl diphosphate + imidazole-4-acetate + ATP = phosphate + pyrophosphate + 1-(5-phosphoribosyl)imidazole-4-acetate + ADP." [EC:6.3.4.8, MetaCyc:6.3.4.8-RXN]
synonym: "5-phosphoribosylimidazoleacetate synthetase activity" EXACT [EC:6.3.4.8]
synonym: "imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)" EXACT [EC:6.3.4.8]
xref: EC:6.3.4.8
xref: MetaCyc:6.3.4.8-RXN
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0047484
name: regulation of response to osmotic stress
namespace: biological_process
def: "Any process that modulates the rate or extent of the response to osmotic stress." [GOC:ai]
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:0006970 ! response to osmotic stress

[Term]
id: GO:0047485
name: protein N-terminus binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "N-terminal binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0047486
name: chondroitin ABC lyase activity
namespace: molecular_function
def: "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [EC:4.2.2.4]
subset: gosubset_prok
xref: EC:4.2.2.4
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047487
name: oligogalacturonide lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(4-deoxy-beta-D-gluc-4-enuronosyl)-D-galacturonate = 25-dehydro-4-deoxy-D-glucuronate." [EC:4.2.2.6, MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN]
subset: gosubset_prok
synonym: "OGTE" RELATED [EC:4.2.2.6]
synonym: "oligogalacturonate lyase activity" EXACT [EC:4.2.2.6]
synonym: "unsaturated oligogalacturonate transeliminase activity" EXACT [EC:4.2.2.6]
xref: EC:4.2.2.6
xref: MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047488
name: heparin lyase activity
namespace: molecular_function
def: "Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.7, MetaCyc:4.2.2.7-RXN]
subset: gosubset_prok
synonym: "heparan sulfate lyase activity" RELATED []
synonym: "heparin eliminase activity" RELATED [EC:4.2.2.7]
synonym: "heparinase activity" EXACT [EC:4.2.2.7]
xref: EC:4.2.2.7
xref: MetaCyc:4.2.2.7-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047489
name: pectate disaccharide-lyase activity
namespace: molecular_function
def: "Catalysis of the eliminative cleavage of 4-(4-deoxy-a-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin." [EC:4.2.2.9]
subset: gosubset_prok
synonym: "(1->4)-alpha-D-galacturonan reducing-end-disaccharide-lyase activity" EXACT [EC:4.2.2.9]
synonym: "exo-PATE" RELATED [EC:4.2.2.9]
synonym: "Exo-PATE activity" EXACT [EC:4.2.2.9]
synonym: "exo-PGL" RELATED [EC:4.2.2.9]
synonym: "Exo-PGL activity" EXACT [EC:4.2.2.9]
synonym: "exopectate lyase activity" EXACT [EC:4.2.2.9]
synonym: "exopectic acid transeliminase activity" EXACT [EC:4.2.2.9]
synonym: "exopolygalacturonate lyase activity" EXACT [EC:4.2.2.9]
synonym: "exopolygalacturonic acid-trans-eliminase activity" EXACT [EC:4.2.2.9]
synonym: "PATE activity" EXACT [EC:4.2.2.9]
synonym: "pectate exo-lyase activity" EXACT [EC:4.2.2.9]
xref: EC:4.2.2.9
xref: MetaCyc:4.2.2.9-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047490
name: pectin lyase activity
namespace: molecular_function
def: "Catalysis of the eliminative cleavage of (14)-a-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-a-D-galact-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.10]
subset: gosubset_prok
synonym: "(1->4)-6-O-methyl-alpha-D-galacturonan lyase activity" EXACT [EC:4.2.2.10]
synonym: "endo-pectin lyase activity" EXACT [EC:4.2.2.10]
synonym: "pectin methyltranseliminase activity" EXACT [EC:4.2.2.10]
synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.10]
synonym: "pectolyase activity" EXACT [EC:4.2.2.10]
synonym: "PL activity" EXACT [EC:4.2.2.10]
synonym: "PMGL activity" EXACT [EC:4.2.2.10]
synonym: "PNL activity" EXACT [EC:4.2.2.10]
synonym: "polymethylgalacturonic transeliminase activity" EXACT [EC:4.2.2.10]
xref: EC:4.2.2.10
xref: MetaCyc:4.2.2.10-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047491
name: poly(alpha-L-guluronate) lyase activity
namespace: molecular_function
def: "Catalysis of the eliminative cleavage of polysaccharides containing a terminal a-L-guluronate group, to give oligopolysaccharides with 4-deoxy-a-L-erythro-hex-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.11]
subset: gosubset_prok
synonym: "alginase II activity" RELATED [EC:4.2.2.11]
synonym: "guluronate lyase activity" EXACT [EC:4.2.2.11]
synonym: "L-guluronan lyase activity" EXACT [EC:4.2.2.11]
synonym: "L-guluronate lyase activity" EXACT [EC:4.2.2.11]
synonym: "poly(alpha-L-1,4-guluronide) exo-lyase activity" EXACT [EC:4.2.2.11]
synonym: "poly-alpha-L-guluronate lyase activity" EXACT [EC:4.2.2.11]
synonym: "polyguluronate-specific alginate lyase activity" EXACT [EC:4.2.2.11]
xref: EC:4.2.2.11
xref: MetaCyc:4.2.2.11-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047492
name: xanthan lyase activity
namespace: molecular_function
def: "Catalysis of the eliminative cleavage of the terminal b-D-mannosyl-b-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-a-L-threo-hex-4-enuronosyl group at the terminus of the side-chain." [EC:4.2.2.12]
xref: EC:4.2.2.12
xref: MetaCyc:4.2.2.12-RXN
is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides

[Term]
id: GO:0047493
name: ceramide cholinephosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-choline + N-acylsphingosine = CMP + sphingomyelin." [EC:2.7.8.3]
subset: gosubset_prok
synonym: "CDP-choline:N-acylsphingosine cholinephosphotransferase activity" EXACT [EC:2.7.8.3]
synonym: "phosphorylcholine-ceramide transferase activity" EXACT [EC:2.7.8.3]
xref: EC:2.7.8.3
xref: MetaCyc:CERAMIDE-CHOLINEPHOSPHOTRANSFERASE-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047494
name: serine-phosphoethanolamine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-ethanolamine + L-serine = CMP + L-serine-phosphoethanolamine." [EC:2.7.8.4]
synonym: "CDP-ethanolamine:L-serine ethanolamine phosphotransferase activity" EXACT [EC:2.7.8.4]
synonym: "serine ethanolamine phosphate synthetase activity" EXACT [EC:2.7.8.4]
synonym: "serine ethanolamine phosphodiester synthase activity" EXACT [EC:2.7.8.4]
synonym: "serine ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.4]
synonym: "serine-phosphinico-ethanolamine synthase activity" EXACT [EC:2.7.8.4]
synonym: "serinephosphoethanolamine synthase activity" EXACT [EC:2.7.8.4]
xref: EC:2.7.8.4
xref: MetaCyc:SERINE-PHOSPHOETHANOLAMINE-SYNTHASE-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047495
name: membrane-oligosaccharide glycerophosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another." [EC:2.7.8.21]
synonym: "membrane-derived-oligosaccharide-6-(glycerophospho)-D-glucose:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" EXACT [EC:2.7.8.21]
synonym: "periplasmic phosphoglycerotransferase activity" NARROW [EC:2.7.8.21]
synonym: "phosphoglycerol cyclase activity" RELATED [EC:2.7.8.21]
xref: EC:2.7.8.21
xref: MetaCyc:2.7.8.21-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0047496
name: vesicle transport along microtubule
namespace: biological_process
def: "The directed movement of a vesicle along a microtubule, mediated by motor proteins." [GOC:ecd]
is_a: GO:0010970 ! microtubule-based transport

[Term]
id: GO:0047497
name: mitochondrion transport along microtubule
namespace: biological_process
def: "The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd]
synonym: "mitochondrial migration along microtubule" EXACT []
synonym: "mitochondrial transport along microtubule" EXACT []
is_a: GO:0010970 ! microtubule-based transport
is_a: GO:0034643 ! mitochondrion localization, microtubule-mediated

[Term]
id: GO:0047498
name: calcium-dependent phospholipase A2 activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate; requires Ca2+." [EC:3.1.1.4]
synonym: "calcium-dependent cytosolic phospholipase A2 activity" NARROW []
synonym: "calcium-dependent secreted phospholipase A2 activity" NARROW []
is_a: GO:0004623 ! phospholipase A2 activity

[Term]
id: GO:0047499
name: calcium-independent phospholipase A2 activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate; does not require Ca2+." [EC:3.1.1.4]
synonym: "calcium-independent cytosolic phospholipase A2 activity" NARROW []
is_a: GO:0004623 ! phospholipase A2 activity

[Term]
id: GO:0047500
name: (+)-borneol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-borneol + NAD+ = (+)-camphor + NADH + H+." [EC:1.1.1.198, MetaCyc:+-BORNEOL-DEHYDROGENASE-RXN]
synonym: "(+)-borneol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.198]
synonym: "bicyclic monoterpenol dehydrogenase activity" EXACT [EC:1.1.1.198]
xref: EC:1.1.1.198
xref: MetaCyc:+-BORNEOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047501
name: (+)-neomenthol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-neomenthol + NADP+ = (-)-menthone + NADPH + H+." [EC:1.1.1.208, MetaCyc:+-NEOMENTHOL-DEHYDROGENASE-RXN]
synonym: "(+)-neomenthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.208]
synonym: "monoterpenoid dehydrogenase activity" BROAD [EC:1.1.1.208]
xref: EC:1.1.1.208
xref: MetaCyc:+-NEOMENTHOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047502
name: (+)-sabinol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-cis-sabinol + NAD+ = (+)-sabinone + NADH + H+." [EC:1.1.1.228, MetaCyc:+-SABINOL-DEHYDROGENASE-RXN]
synonym: "(+)-cis-sabinol dehydrogenase activity" EXACT [EC:1.1.1.228]
synonym: "(+)-cis-sabinol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.228]
xref: EC:1.1.1.228
xref: MetaCyc:+-SABINOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047503
name: (-)-borneol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-borneol + NAD+ = (-)-camphor + NADH + H+." [EC:1.1.1.227, MetaCyc:--BORNEOL-DEHYDROGENASE-RXN]
synonym: "(-)-borneol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.227]
xref: EC:1.1.1.227
xref: MetaCyc:--BORNEOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047504
name: (-)-menthol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-menthol + NADP+ = (-)-menthone + NADPH + H+." [EC:1.1.1.207, MetaCyc:--MENTHOL-DEHYDROGENASE-RXN]
synonym: "(-)-menthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.207]
synonym: "monoterpenoid dehydrogenase activity" BROAD [EC:1.1.1.207]
xref: EC:1.1.1.207
xref: MetaCyc:--MENTHOL-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0741
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047505
name: (-)-menthol monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-menthol + NADPH + H+ + O2 = p-menthane-3,8-diol + NADP+ + H2O." [EC:1.14.13.46, MetaCyc:--MENTHOL-MONOOXYGENASE-RXN]
synonym: "(-)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.13.46]
synonym: "l-menthol monooxygenase activity" EXACT [EC:1.14.13.46]
xref: EC:1.14.13.46
xref: MetaCyc:--MENTHOL-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047506
name: (deoxy)adenylate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + dAMP = ADP + dADP." [EC:2.7.4.11, MetaCyc:DEOXYADENYLATE-KINASE-RXN]
synonym: "ATP:(d)AMP phosphotransferase activity" EXACT [EC:2.7.4.11]
xref: EC:2.7.4.11
xref: MetaCyc:DEOXYADENYLATE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0047507
name: (deoxy)nucleoside-phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate." [EC:2.7.4.13, MetaCyc:DEOXYNUCLEOSIDE-PHOSPHATE-KINASE-RXN]
synonym: "ATP:deoxynucleoside-phosphate phosphotransferase activity" EXACT [EC:2.7.4.13]
synonym: "deoxynucleoside monophosphate kinase activity" EXACT [EC:2.7.4.13]
synonym: "deoxynucleoside-5'-monophosphate kinase activity" EXACT [EC:2.7.4.13]
synonym: "deoxyribonucleoside monophosphokinase activity" EXACT [EC:2.7.4.13]
xref: EC:2.7.4.13
xref: MetaCyc:DEOXYNUCLEOSIDE-PHOSPHATE-KINASE-RXN
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity

[Term]
id: GO:0047508
name: (R)-2-methylmalate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-methylmalate = 2-methylmaleate + H2O." [EC:4.2.1.35, MetaCyc:R-2-METHYLMALATE-DEHYDRATASE-RXN]
synonym: "(-)-citramalate hydro-lyase activity" EXACT [EC:4.2.1.35]
synonym: "(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)" EXACT [EC:4.2.1.35]
synonym: "(R)-2-methylmalate hydro-lyase activity" EXACT [EC:4.2.1.35]
synonym: "citraconase activity" EXACT [EC:4.2.1.35]
synonym: "citraconate hydratase activity" EXACT [EC:4.2.1.35]
synonym: "citramalate hydro-lyase activity" EXACT [EC:4.2.1.35]
xref: EC:4.2.1.35
xref: MetaCyc:R-2-METHYLMALATE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047509
name: (R)-dehydropantoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-4-dehydropantoate + NAD+ + H2O = (R)-3,3-dimethylmalate + NADH + H+." [EC:1.2.1.33, MetaCyc:R-DEHYDROPANTOATE-DEHYDROGENASE-RXN]
synonym: "(R)-4-dehydropantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.2.1.33]
synonym: "D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine nucleotide (DPN+) oxidoreductase activity" EXACT [EC:1.2.1.33]
synonym: "D-aldopantoate dehydrogenase activity" EXACT [EC:1.2.1.33]
xref: EC:1.2.1.33
xref: MetaCyc:R-DEHYDROPANTOATE-DEHYDROGENASE-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047510
name: (S)-2-methylmalate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-methylmalate = 2-methylfumarate + H2O." [EC:4.2.1.34, MetaCyc:S-2-METHYLMALATE-DEHYDRATASE-RXN]
synonym: "(+)-citramalate hydro-lyase activity" EXACT [EC:4.2.1.34]
synonym: "(+)-citramalic hydro-lyase activity" EXACT [EC:4.2.1.34]
synonym: "(S)-2-methylmalate hydro-lyase (2-methylfumarate-forming)" EXACT [EC:4.2.1.34]
synonym: "(S)-2-methylmalate hydro-lyase activity" EXACT [EC:4.2.1.34]
synonym: "citramalate dehydratase activity" EXACT [EC:4.2.1.34]
synonym: "L-citramalate hydrolase activity" EXACT [EC:4.2.1.34]
synonym: "mesaconase activity" EXACT [EC:4.2.1.34]
synonym: "mesaconate hydratase activity" EXACT [EC:4.2.1.34]
synonym: "mesaconate mesaconase activity" EXACT [EC:4.2.1.34]
xref: EC:4.2.1.34
xref: MetaCyc:S-2-METHYLMALATE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047511
name: (S)-methylmalonyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-methylmalonyl-CoA + H2O = methylmalonate + CoA." [EC:3.1.2.17, MetaCyc:S-METHYLMALONYL-COA-HYDROLASE-RXN]
synonym: "D-methylmalonyl-coenzyme A hydrolase activity" EXACT [EC:3.1.2.17]
xref: EC:3.1.2.17
xref: MetaCyc:S-METHYLMALONYL-COA-HYDROLASE-RXN
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0047512
name: (S,S)-butanediol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD+ = acetoin + NADH + H+." [EC:1.1.1.76, MetaCyc:SS-BUTANEDIOL-DEHYDROGENASE-RXN]
synonym: "(S,S)-butane-2,3-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.76]
synonym: "L(+)-2,3-butanediol dehydrogenase (L-acetoin forming)" EXACT [EC:1.1.1.76]
synonym: "L-BDH" RELATED [EC:1.1.1.76]
synonym: "L-butanediol dehydrogenase activity" EXACT [EC:1.1.1.76]
xref: EC:1.1.1.76
xref: MetaCyc:SS-BUTANEDIOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047513
name: 1,2-alpha-L-fucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside." [EC:3.2.1.63, MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN]
synonym: "2-alpha-L-fucopyranosyl-beta-D-galactoside fucohydrolase activity" EXACT [EC:3.2.1.63]
synonym: "almond emulsin fucosidase activity" EXACT [EC:3.2.1.63]
synonym: "almond emulsin fucosidase II activity" NARROW [EC:3.2.1.63]
synonym: "alpha-(1->2)-L-fucosidase activity" EXACT [EC:3.2.1.63]
xref: EC:3.2.1.63
xref: MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN
is_a: GO:0004560 ! alpha-L-fucosidase activity

[Term]
id: GO:0047514
name: 1,3-beta-D-glucan phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,3-beta-D-glucosyl(n) + phosphate = 1,3-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate; substrates include laminarin." [EC:2.4.1.97, MetaCyc:13-BETA-GLUCAN-PHOSPHORYLASE-RXN]
synonym: "1,3-beta-D-glucan:orthophosphate glucosyltransferase activity" EXACT [EC:2.4.1.97]
synonym: "1,3-beta-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.97]
synonym: "1,3-beta-glucan phosphorylase activity" EXACT []
synonym: "laminarin phosphorylase activity" RELATED [EC:2.4.1.97]
synonym: "laminarin phosphoryltransferase activity" EXACT [EC:2.4.1.97]
xref: EC:2.4.1.97
xref: MetaCyc:13-BETA-GLUCAN-PHOSPHORYLASE-RXN
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0047515
name: 1,3-beta-oligoglucan phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: oligomeric 1,3-beta-D-glucosyl(n) + phosphate = 1,3-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.30, MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN]
synonym: "1,3-beta-D-oligoglucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.30]
synonym: "beta-1,3-oligoglucan phosphorylase activity" EXACT [EC:2.4.1.30]
synonym: "beta-1,3-oligoglucan:orthophosphate glucosyltransferase II activity" EXACT [EC:2.4.1.30]
xref: EC:2.4.1.30
xref: MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0047516
name: 1,3-propanediol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+." [EC:1.1.1.202, MetaCyc:13-PROPANEDIOL-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "1,3-PD:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.202]
synonym: "1,3-propanediol oxidoreductase activity" EXACT [EC:1.1.1.202]
synonym: "1,3-propanediol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.202]
synonym: "3-hydroxypropionaldehyde reductase activity" EXACT [EC:1.1.1.202]
synonym: "propane-1,3-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.202]
xref: EC:1.1.1.202
xref: MetaCyc:13-PROPANEDIOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047517
name: 1,4-beta-D-xylan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-xylose + 1,4-beta-D-xylan(n) = UDP + 1,4-beta-D-xylan(n+1)." [EC:2.4.2.24, MetaCyc:1\,4-BETA-D-XYLAN-SYNTHASE-RXN]
synonym: "1,4-beta-xylan synthase activity" EXACT [EC:2.4.2.24]
synonym: "UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.24]
synonym: "uridine diphosphoxylose-1,4-beta-xylan xylosyltransferase activity" EXACT [EC:2.4.2.24]
synonym: "xylan synthase activity" EXACT [EC:2.4.2.24]
synonym: "xylan synthetase activity" EXACT [EC:2.4.2.24]
xref: EC:2.4.2.24
xref: MetaCyc:RXN-9104
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0047518
name: 1-methyladenosine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-methyladenosine + H2O = 1-methyladenine + D-ribose." [EC:3.2.2.13, MetaCyc:1-METHYLADENOSINE-NUCLEOSIDASE-RXN]
synonym: "1-methyladenosine hydrolase activity" EXACT [EC:3.2.2.13]
synonym: "1-methyladenosine ribohydrolase activity" EXACT [EC:3.2.2.13]
xref: EC:3.2.2.13
xref: MetaCyc:1-METHYLADENOSINE-NUCLEOSIDASE-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047519
name: quinate dehydrogenase (pyrroloquinoline-quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: quinate + pyrroloquinoline-quinone = 5-dehydroquinate + reduced pyrroloquinoline-quinone." [EC:1.1.99.25, MetaCyc:1.1.99.25-RXN]
subset: gosubset_prok
synonym: "NAD(P)-independent quinate dehydrogenase activity" EXACT [EC:1.1.99.25]
synonym: "quinate:pyrroloquinoline-quinone 3-oxidoreductase activity" EXACT [EC:1.1.99.25]
synonym: "quinate:pyrroloquinoline-quinone 5-oxidoreductase activity" EXACT [EC:1.1.99.25]
xref: EC:1.1.99.25
xref: MetaCyc:1.1.99.25-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047520
name: 11-cis-retinyl-palmitate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 11-cis-retinyl palmitate + H2O = 11-cis-retinol + palmitate." [EC:3.1.1.63, MetaCyc:11-CIS-RETINYL-PALMITATE-HYDROLASE-RXN]
synonym: "11-cis-retinol palmitate esterase activity" EXACT [EC:3.1.1.63]
synonym: "11-cis-retinyl-palmitate acylhydrolase activity" EXACT [EC:3.1.1.63]
synonym: "RPH" RELATED [EC:3.1.1.63]
xref: EC:3.1.1.63
xref: MetaCyc:11-CIS-RETINYL-PALMITATE-HYDROLASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047521
name: 12-beta-hydroxysteroid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-alpha,7-alpha,12-beta-trihydroxy-5-beta-cholanate + NADP+ = 3-alpha,7-alpha-dihydroxy-12-oxo-5-beta-cholanate + NADPH + H+." [EC:1.1.1.238, MetaCyc:12-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN]
synonym: "12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.238]
synonym: "12beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.238]
synonym: "12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity" EXACT [EC:1.1.1.238]
xref: EC:1.1.1.238
xref: MetaCyc:12-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047522
name: 15-oxoprostaglandin 13-oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ = (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+." [EC:1.3.1.48, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN]
synonym: "(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta13-oxidoreductase activity" EXACT [EC:1.3.1.48]
synonym: "15-ketoprostaglandin delta13-reductase activity" EXACT [EC:1.3.1.48]
synonym: "15-oxo-delta13-prostaglandin reductase activity" EXACT [EC:1.3.1.48]
synonym: "15-oxoprostaglandin 13-reductase activity" EXACT []
synonym: "delta13-15-ketoprostaglandin reductase activity" EXACT [EC:1.3.1.48]
synonym: "prostaglandin 13-reductase activity" EXACT [EC:1.3.1.48]
synonym: "prostaglandin delta13-reductase activity" EXACT [EC:1.3.1.48]
xref: EC:1.3.1.48
xref: MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047524
name: 16-hydroxysteroid epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroid." [EC:5.1.99.2, MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN]
synonym: "16-hydroxysteroid 16-epimerase activity" EXACT [EC:5.1.99.2]
xref: EC:5.1.99.2
xref: MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0047525
name: 2'-hydroxydaidzein reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2'-hydroxydihydrodaidzein + NADP+ = 2'-hydroxydaidzein + NADPH + H+." [EC:1.3.1.51, MetaCyc:2'-HYDROXYDAIDZEIN-REDUCTASE-RXN]
synonym: "2'-hydroxy-2,3-dihydrodaidzein:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.3.1.51]
synonym: "2'-hydroxydihydrodaidzein:NADP(+) 2'-oxidoreductase activity" EXACT [EC:1.3.1.51]
synonym: "2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.3.1.51]
synonym: "HDR activity" EXACT [EC:1.3.1.51]
synonym: "NADPH:2'-hydroxydaidzein oxidoreductase activity" EXACT [EC:1.3.1.51]
xref: EC:1.3.1.51
xref: MetaCyc:RXN-4502
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047526
name: 2'-hydroxyisoflavone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+." [EC:1.3.1.45, MetaCyc:2-HYDROXYISOFLAVONE-REDUCTASE-RXN]
subset: gosubset_prok
synonym: "2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase activity" EXACT [EC:1.3.1.45]
synonym: "isoflavone reductase activity" EXACT [EC:1.3.1.45]
synonym: "NADPH:2'-hydroxyisoflavone oxidoreductase activity" EXACT [EC:1.3.1.45]
synonym: "vestitone:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.45]
xref: EC:1.3.1.45
xref: MetaCyc:2-HYDROXYISOFLAVONE-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047527
name: 2,3-dihydroxybenzoate-serine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine." [EC:6.3.2.14, MetaCyc:1\,3-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN]
synonym: "2,3-dihydroxybenzoate:L-serine ligase activity" EXACT [EC:6.3.2.14]
synonym: "2,3-dihydroxybenzoylserine synthetase activity" EXACT [EC:6.3.2.14]
synonym: "N-(2,3-dihydroxybenzoyl)-serine synthetase activity" EXACT [EC:6.3.2.14]
xref: EC:6.3.2.14
xref: MetaCyc:23-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047528
name: 2,3-dihydroxyindole 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxyindole + O2 = anthranilate + CO2." [EC:1.13.11.23, MetaCyc:23-DIHYDROXYINDOLE-23-DIOXYGENASE-RXN]
synonym: "2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing) activity" EXACT [EC:1.13.11.23]
xref: EC:1.13.11.23
xref: MetaCyc:23-DIHYDROXYINDOLE-23-DIOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047529
name: 2,3-dimethylmalate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dimethylmalate = propanoate + pyruvate." [EC:4.1.3.32, MetaCyc:23-DIMETHYLMALATE-LYASE-RXN]
synonym: "(2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)" EXACT [EC:4.1.3.32]
synonym: "(2R,3S)-2,3-dimethylmalate pyruvate-lyase activity" EXACT [EC:4.1.3.32]
synonym: "2,3-dimethylmalate pyruvate-lyase activity" EXACT [EC:4.1.3.32]
xref: EC:4.1.3.32
xref: MetaCyc:23-DIMETHYLMALATE-LYASE-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047530
name: 2,4-diaminopentanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+." [EC:1.4.1.12, MetaCyc:24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN]
synonym: "2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.12]
synonym: "2,4-diaminopentanoic acid C4 dehydrogenase activity" EXACT [EC:1.4.1.12]
xref: EC:1.4.1.12
xref: MetaCyc:24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047531
name: 2,5-diaminovalerate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-diaminopentanoate + 2-oxoglutarate = 5-amino-2-oxopentanoate + L-glutamate." [EC:2.6.1.8, MetaCyc:25-DIAMINOVALERATE-AMINOTRANSFERASE-RXN]
synonym: "2,5-diaminopentanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.8]
synonym: "2,5-diaminovalerate aminotransferase activity" EXACT []
synonym: "diamino acid aminotransferase activity" EXACT [EC:2.6.1.8]
synonym: "diamino-acid aminotransferase activity" RELATED [EC:2.6.1.8]
synonym: "diamino-acid transaminase activity" EXACT [EC:2.6.1.8]
xref: EC:2.6.1.8
xref: MetaCyc:25-DIAMINOVALERATE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047532
name: 2,5-dioxopiperazine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dioxopiperazine + H2O = glycylglycine." [EC:3.5.2.13, MetaCyc:25-DIOXOPIPERAZINE-HYDROLASE-RXN]
synonym: "2,5-dioxopiperazine amidohydrolase activity" EXACT [EC:3.5.2.13]
synonym: "cyclo(Gly-Gly) hydrolase activity" EXACT [EC:3.5.2.13]
synonym: "cyclo(glycylglycine) hydrolase activity" EXACT [EC:3.5.2.13]
xref: EC:3.5.2.13
xref: MetaCyc:25-DIOXOPIPERAZINE-HYDROLASE-RXN
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0047533
name: 2,5-dioxovalerate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+." [EC:1.2.1.26, MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN]
synonym: "2,5-dioxopentanoate:NADP+ 5-oxidoreductase activity" EXACT [EC:1.2.1.26]
synonym: "2-oxoglutarate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.26]
synonym: "alpha-ketoglutaric semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.26]
xref: EC:1.2.1.26
xref: MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047534
name: 2-acetolactate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate." [EC:5.4.99.3, MetaCyc:2-ACETOLACTATE-MUTASE-RXN]
synonym: "2-acetolactate methylmutase activity" EXACT [EC:5.4.99.3]
synonym: "acetohydroxy acid isomerase activity" BROAD [EC:5.4.99.3]
synonym: "acetolactate mutase activity" EXACT [EC:5.4.99.3]
xref: EC:5.4.99.3
xref: MetaCyc:2-ACETOLACTATE-MUTASE-RXN
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047535
name: 2-alkyn-1-ol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-butyne-1,4-diol + NAD+ = 4-hydroxy-2-butynal + NADH + H+." [EC:1.1.1.165, MetaCyc:2-ALKYN-1-OL-DEHYDROGENASE-RXN]
synonym: "2-butyne-1,4-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.165]
xref: EC:1.1.1.165
xref: MetaCyc:2-ALKYN-1-OL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047536
name: 2-aminoadipate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate." [EC:2.6.1.39, MetaCyc:2-AMINOADIPATE-AMINOTRANSFERASE-RXN]
synonym: "2-aminoadipate aminotransferase activity" EXACT []
synonym: "2-aminoadipic aminotransferase activity" EXACT [EC:2.6.1.39]
synonym: "alpha-aminoadipate aminotransferase activity" EXACT [EC:2.6.1.39]
synonym: "glutamate-alpha-ketoadipate transaminase activity" EXACT [EC:2.6.1.39]
synonym: "glutamic-ketoadipic transaminase activity" EXACT [EC:2.6.1.39]
synonym: "L-2-aminoadipate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.39]
xref: EC:2.6.1.39
xref: MetaCyc:2-AMINOADIPATE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047537
name: 2-aminohexanoate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate." [EC:2.6.1.67, MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN]
synonym: "2-aminohexanoate aminotransferase activity" EXACT []
synonym: "L-2-aminohexanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.67]
synonym: "leucine L-norleucine: 2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.67]
synonym: "norleucine (leucine) aminotransferase activity" EXACT [EC:2.6.1.67]
synonym: "norleucine aminotransferase activity" EXACT [EC:2.6.1.67]
synonym: "norleucine transaminase activity" EXACT [EC:2.6.1.67]
xref: EC:2.6.1.67
xref: MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047538
name: 2-carboxy-D-arabinitol-1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate." [EC:3.1.3.63, MetaCyc:2-CARBOXY-D-ARABINITOL-1-PHOSPHATASE-RXN]
synonym: "2-carboxy-D-arabinitol 1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.63]
synonym: "2-carboxy-D-arabinitol-1-phosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.63]
synonym: "2-carboxyarabinitol 1-phosphatase activity" EXACT [EC:3.1.3.63]
xref: EC:3.1.3.63
xref: MetaCyc:2-CARBOXY-D-ARABINITOL-1-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047539
name: 2-deoxyglucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol." [EC:3.2.1.112, MetaCyc:2-DEOXYGLUCOSIDASE-RXN]
synonym: "2-deoxy-alpha-D-glucosidase activity" EXACT [EC:3.2.1.112]
synonym: "2-deoxy-alpha-D-glucoside deoxyglucohydrolase activity" EXACT [EC:3.2.1.112]
synonym: "2-deoxy-alpha-glucosidase activity" EXACT [EC:3.2.1.112]
xref: EC:3.2.1.112
xref: MetaCyc:2-DEOXYGLUCOSIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047540
name: 2-enoate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanoate + NAD+ = 2-butenoate + NADH + H+." [EC:1.3.1.31, MetaCyc:2-ENOATE-REDUCTASE-RXN]
subset: gosubset_prok
synonym: "butanoate:NAD+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.31]
synonym: "enoate reductase activity" EXACT [EC:1.3.1.31]
xref: EC:1.3.1.31
xref: MetaCyc:2-ENOATE-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047541
name: 2-furoate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2-furoate + CoA = AMP + diphosphate + 2-furoyl-CoA." [EC:6.2.1.31, MetaCyc:2-FUROATE--COA-LIGASE-RXN]
synonym: "2-furoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.31]
synonym: "2-furoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.31]
xref: EC:6.2.1.31
xref: MetaCyc:2-FUROATE--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047542
name: 2-furoyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-furoyl-CoA + H2O + acceptor = S-(5-hydroxy-2-furoyl)-CoA + reduced acceptor." [EC:1.3.99.8, MetaCyc:2-FUROYL-COA-DEHYDROGENASE-RXN]
synonym: "2-furoyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.8]
synonym: "2-furoyl coenzyme A hydroxylase activity" EXACT [EC:1.3.99.8]
synonym: "2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.8]
synonym: "2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.8]
synonym: "furoyl-CoA hydroxylase activity" EXACT [EC:1.3.99.8]
xref: EC:1.3.99.8
xref: MetaCyc:2-FUROYL-COA-DEHYDROGENASE-RXN
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047543
name: 2-hexadecenal reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexadecanal + NADP+ = 2-trans-hexadecenal + NADPH + H+." [EC:1.3.1.27, MetaCyc:2-HEXADECENAL-REDUCTASE-RXN]
synonym: "hexadecanal: NADP+ oxidoreductase activity" EXACT [EC:1.3.1.27]
synonym: "hexadecanal:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.27]
xref: EC:1.3.1.27
xref: MetaCyc:2-HEXADECENAL-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047544
name: 2-hydroxybiphenyl 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxybiphenyl + NADH + H+ + O2 = 2,3-dihydroxybiphenyl + NAD+ + H2O." [EC:1.14.13.44, MetaCyc:2-HYDROXYBIPHENYL-3-MONOOXYGENASE-RXN]
synonym: "2-hydroxybiphenyl,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.44]
xref: EC:1.14.13.44
xref: MetaCyc:2-HYDROXYBIPHENYL-3-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0896
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047545
name: 2-hydroxyglutarate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase" EXACT [EC:1.1.99.2]
synonym: "(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase" EXACT [EC:1.1.99.2]
synonym: "alpha-hydroxyglutarate dehydrogenase (NAD+ specific)" NARROW [EC:1.1.99.2]
synonym: "alpha-hydroxyglutarate dehydrogenase activity" EXACT [EC:1.1.99.2]
synonym: "alpha-hydroxyglutarate oxidoreductase activity" EXACT [EC:1.1.99.2]
synonym: "alpha-ketoglutarate reductase activity" EXACT [EC:1.1.99.2]
synonym: "hydroxyglutaric dehydrogenase activity" EXACT [EC:1.1.99.2]
synonym: "L-alpha-hydroxyglutarate dehydrogenase activity" EXACT [EC:1.1.99.2]
synonym: "L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase" NARROW [EC:1.1.99.2]
xref: EC:1.1.99.2
xref: MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047546
name: 2-hydroxypyridine 5-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxypyridine + donor-H2 + O2 = 2,5-dihydroxypyridine + acceptor + H2O." [EC:1.14.99.26, MetaCyc:2-HYDROXYPYRIDINE-5-MONOOXYGENASE-RXN]
synonym: "2-hydroxypyridine oxygenase activity" EXACT [EC:1.14.99.26]
synonym: "2-hydroxypyridine,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.99.26]
xref: EC:1.14.99.26
xref: MetaCyc:2-HYDROXYPYRIDINE-5-MONOOXYGENASE-RXN
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0047547
name: 2-methylcitrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O." [EC:4.2.1.79, MetaCyc:2-METHYLCITRATE-DEHYDRATASE-RXN]
subset: gosubset_prok
synonym: "(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]" RELATED [EC:4.2.1.79]
synonym: "2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.79]
synonym: "2-methylcitrate hydro-lyase activity" EXACT [EC:4.2.1.79]
synonym: "prpD" RELATED [EC:4.2.1.79]
xref: EC:4.2.1.79
xref: MetaCyc:2-METHYLCITRATE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047548
name: 2-methyleneglutarate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate." [EC:5.4.99.4, MetaCyc:2-METHYLENEGLUTARATE-MUTASE-RXN]
subset: gosubset_prok
synonym: "2-methyleneglutarate carboxy-methylenemethylmutase activity" EXACT [EC:5.4.99.4]
synonym: "alpha-methyleneglutarate mutase activity" EXACT [EC:5.4.99.4]
xref: EC:5.4.99.4
xref: MetaCyc:2-METHYLENEGLUTARATE-MUTASE-RXN
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047549
name: 2-nitrophenol 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-nitrophenol + NADPH + H+ + O2 = catechol + NO2(-) (nitrite) + NADP+ + H2O." [EC:1.14.13.31, MetaCyc:2-NITROPHENOL-2-MONOOXYGENASE-RXN]
synonym: "2-nitrophenol oxygenase activity" EXACT [EC:1.14.13.31]
synonym: "2-nitrophenol,NADPH:oxygen 2-oxidoreductase (2-hydroxylating, nitrite-forming)" EXACT [EC:1.14.13.31]
synonym: "nitrophenol oxygenase activity" BROAD [EC:1.14.13.31]
xref: EC:1.14.13.31
xref: MetaCyc:2-NITROPHENOL-2-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0951
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047550
name: 2-oxoadipate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxyadipate + NAD+ = 2-oxoadipate + NADH + H+." [EC:1.1.1.172, MetaCyc:2-OXOADIPATE-REDUCTASE-RXN]
synonym: "2-hydroxyadipate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.172]
synonym: "2-ketoadipate reductase activity" EXACT [EC:1.1.1.172]
synonym: "alpha-ketoadipate reductase activity" EXACT [EC:1.1.1.172]
xref: EC:1.1.1.172
xref: MetaCyc:2-OXOADIPATE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047551
name: 2-oxoaldehyde dehydrogenase (NAD) activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+." [EC:1.2.1.23, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN]
synonym: "2-ketoaldehyde dehydrogenase" BROAD [EC:1.2.1.23]
synonym: "2-oxoaldehyde dehydrogenase (NAD+)" EXACT [EC:1.2.1.23]
synonym: "2-oxoaldehyde:NAD+ 2-oxidoreductase activity" EXACT [EC:1.2.1.23]
synonym: "alpha-ketoaldehyde dehydrogenase activity" BROAD [EC:1.2.1.23]
synonym: "methylglyoxal dehydrogenase activity" BROAD [EC:1.2.1.23]
synonym: "NAD-dependent alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.23]
synonym: "NAD-linked alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.23]
xref: EC:1.2.1.23
xref: MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN
xref: Wikipedia:2-oxoaldehyde_dehydrogenase_(NAD+)
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047552
name: 2-oxoaldehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo acid + NADPH + H+." [EC:1.2.1.49, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NADP+-RXN]
synonym: "2-ketoaldehyde dehydrogenase" BROAD [EC:1.2.1.49]
synonym: "2-oxoaldehyde:NADP+ 2-oxidoreductase activity" EXACT [EC:1.2.1.49]
synonym: "alpha-ketoaldehyde dehydrogenase activity" BROAD [EC:1.2.1.49]
synonym: "methylglyoxal dehydrogenase activity" BROAD [EC:1.2.1.49]
synonym: "NADP-dependent alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.49]
synonym: "NADP-linked alpha-ketoaldehyde dehydrogenase activity" EXACT [EC:1.2.1.49]
xref: EC:1.2.1.49
xref: MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047553
name: 2-oxoglutarate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.3, MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN]
subset: gosubset_prok
synonym: "2-ketoglutarate ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3]
synonym: "2-oxoglutarate ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3]
synonym: "2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating)" EXACT [EC:1.2.7.3]
synonym: "2-oxoglutarate:ferredoxin 2-oxidoreductase (decarboxylating)" EXACT [EC:1.2.7.3]
synonym: "2-oxoglutarate:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3]
synonym: "alpha-ketoglutarate synthase activity" EXACT [EC:1.2.7.3]
synonym: "alpha-ketoglutarate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.3]
synonym: "KGOR activity" EXACT [EC:1.2.7.3]
xref: EC:1.2.7.3
xref: MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN
is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0047554
name: 2-pyrone-4,6-dicarboxylate lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-pyrone-4,6-dicarboxylate + H2O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate." [EC:3.1.1.57, MetaCyc:2-PYRONE-4\,6-DICARBOXYLATE-LACTONASE-RXN]
subset: gosubset_prok
synonym: "2-pyrone-4,6-dicarboxylate lactonohydrolase activity" EXACT [EC:3.1.1.57]
xref: EC:3.1.1.57
xref: MetaCyc:RXN-2462
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047555
name: 3',5'-cyclic-GMP phosphodiesterase activity
namespace: molecular_function
alt_id: GO:0004116
def: "Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate." [EC:3.1.4.35, MetaCyc:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN]
synonym: "3',5' cyclic-GMP phosphodiesterase activity" EXACT []
synonym: "3',5'-cyclic-GMP 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.35]
synonym: "cGMP phosphodiesterase activity" EXACT []
synonym: "cGMP-PDE" RELATED [EC:3.1.4.35]
synonym: "cGMP-specific phosphodiesterase activity" EXACT []
synonym: "cyclic 3',5'-GMP phosphodiesterase activity" EXACT [EC:3.1.4.35]
synonym: "cyclic GMP phosphodiesterase activity" EXACT []
synonym: "cyclic guanosine 3',5'-monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.35]
synonym: "cyclic guanosine 3',5'-phosphate phosphodiesterase activity" EXACT [EC:3.1.4.35]
synonym: "guanosine cyclic 3',5'-phosphate phosphodiesterase activity" EXACT []
xref: EC:3.1.4.35
xref: MetaCyc:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN
is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity

[Term]
id: GO:0047556
name: 3,4-dihydroxyphthalate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2." [EC:4.1.1.69]
synonym: "3,4-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" EXACT [EC:4.1.1.69]
synonym: "3,4-dihydroxyphthalate carboxy-lyase activity" EXACT [EC:4.1.1.69]
xref: EC:4.1.1.69
xref: MetaCyc:34-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN
xref: UM-BBD_enzymeID:e0916
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047557
name: 3-aci-nitropropanoate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + O2 + 3-aci-nitropropanoate = NO2(-) (nitrite) + H2O2 + 3-oxopropanoate." [EC:1.7.3.5, MetaCyc:3-ACI-NITROPROPANOATE-OXIDASE-RXN]
synonym: "3-aci-nitropropanoate:oxygen oxidoreductase activity" EXACT [EC:1.7.3.5]
synonym: "propionate-3-nitronate oxidase activity" EXACT [EC:1.7.3.5]
xref: EC:1.7.3.5
xref: MetaCyc:3-ACI-NITROPROPANOATE-OXIDASE-RXN
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

[Term]
id: GO:0047558
name: 3-cyanoalanine hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-asparagine = 3-cyanoalanine + H2O." [EC:4.2.1.65, MetaCyc:3-CYANOALANINE-HYDRATASE-RXN]
synonym: "beta-CNA nitrilase activity" EXACT [EC:4.2.1.65]
synonym: "beta-CNAla hydrolase activity" EXACT [EC:4.2.1.65]
synonym: "beta-cyanoalanine hydratase activity" EXACT [EC:4.2.1.65]
synonym: "beta-cyanoalanine hydrolase activity" EXACT [EC:4.2.1.65]
synonym: "L-asparagine hydro-lyase (3-cyanoalanine-forming)" EXACT [EC:4.2.1.65]
synonym: "L-asparagine hydro-lyase activity" EXACT [EC:4.2.1.65]
xref: EC:4.2.1.65
xref: MetaCyc:3-CYANOALANINE-HYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047559
name: 3-dehydro-L-gulonate 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+." [EC:1.1.1.130, MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN]
synonym: "2,3-diketo-L-gulonate reductase activity" EXACT [EC:1.1.1.130]
synonym: "3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.130]
synonym: "3-keto-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.130]
synonym: "3-ketogulonate dehydrogenase activity" EXACT [EC:1.1.1.130]
xref: EC:1.1.1.130
xref: MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047560
name: 3-dehydrosphinganine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: sphinganine + NADP+ = 3-dehydrosphinganine + NADPH + H+." [EC:1.1.1.102, MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN]
synonym: "3-ketosphinganine reductase activity" EXACT [EC:1.1.1.102]
synonym: "3-oxosphinganine reductase activity" EXACT [EC:1.1.1.102]
synonym: "3-oxosphinganine:NADPH oxidoreductase activity" EXACT [EC:1.1.1.102]
synonym: "D-3-dehydrosphinganine reductase activity" EXACT [EC:1.1.1.102]
synonym: "D-3-oxosphinganine reductase activity" EXACT [EC:1.1.1.102]
synonym: "D-3-oxosphinganine:B-NADPH oxidoreductase activity" EXACT [EC:1.1.1.102]
synonym: "D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.102]
synonym: "DSR activity" EXACT [EC:1.1.1.102]
synonym: "KTS reductase activity" RELATED [EC:1.1.1.102]
xref: EC:1.1.1.102
xref: MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047561
name: 3-hydroxyanthranilate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2." [EC:1.10.3.5, MetaCyc:3-HYDROXYANTHRANILATE-OXIDASE-RXN]
synonym: "3-hydroxyanthranilate:oxygen oxidoreductase activity" EXACT [EC:1.10.3.5]
synonym: "3-hydroxyanthranilic acid oxidase activity" EXACT [EC:1.10.3.5]
xref: EC:1.10.3.5
xref: MetaCyc:3-HYDROXYANTHRANILATE-OXIDASE-RXN
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0047562
name: 3-hydroxyaspartate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = glycine + glyoxylate." [EC:4.1.3.14, MetaCyc:3-HYDROXYASPARTATE-ALDOLASE-RXN]
synonym: "erythro-3-hydroxy-L(s)-aspartate glyoxylate-lyase activity" EXACT [EC:4.1.3.14]
synonym: "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase (glycine-forming)" EXACT [EC:4.1.3.14]
synonym: "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase activity" EXACT [EC:4.1.3.14]
synonym: "erythro-beta-hydroxyaspartate aldolase activity" EXACT [EC:4.1.3.14]
synonym: "erythro-beta-hydroxyaspartate glycine-lyase activity" EXACT [EC:4.1.3.14]
xref: EC:4.1.3.14
xref: MetaCyc:3-HYDROXYASPARTATE-ALDOLASE-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047563
name: 3-hydroxybenzoate 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxybenzoate + donor-H2 + O2 = 2,3-dihydroxybenzoate + acceptor + H2O." [EC:1.14.99.23, MetaCyc:3-HYDROXYBENZOATE-2-MONOOXYGENASE-RXN]
synonym: "3-HBA-2-hydroxylase activity" EXACT [EC:1.14.99.23]
synonym: "3-hydroxybenzoate 2-hydroxylase activity" EXACT []
synonym: "3-hydroxybenzoate,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.99.23]
xref: EC:1.14.99.23
xref: MetaCyc:3-HYDROXYBENZOATE-2-MONOOXYGENASE-RXN
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0047564
name: 3-hydroxycyclohexanone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxycyclohexanone + acceptor = cyclohexane-1,3-dione + reduced acceptor." [EC:1.1.99.26, MetaCyc:3-HYDROXYCYCLOHEXANONE-DEHYDROGENASE-RXN]
synonym: "3-hydroxycyclohexanone:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.26]
xref: EC:1.1.99.26
xref: MetaCyc:3-HYDROXYCYCLOHEXANONE-DEHYDROGENASE-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047565
name: 3-hydroxypropionate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypropanoate + NAD+ = 3-oxopropanoate + NADH + H+." [EC:1.1.1.59, MetaCyc:3-HYDROXYPROPIONATE-DEHYDROGENASE-RXN]
synonym: "3-hydroxypropanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.59]
xref: EC:1.1.1.59
xref: MetaCyc:3-HYDROXYPROPIONATE-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047566
name: 3-ketovalidoxylamine C-N-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one." [EC:4.3.3.1, MetaCyc:3-KETOVALIDOXYLAMINE-C-N-LYASE-RXN]
synonym: "3-ketovalidoxylamine A C-N-lyase activity" EXACT [EC:4.3.3.1]
synonym: "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase [5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one-forming]" RELATED [EC:4.3.3.1]
synonym: "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase activity" EXACT [EC:4.3.3.1]
synonym: "p-nitrophenyl-3-ketovalidamine p-nitroaniline lyase activity" EXACT [EC:4.3.3.1]
xref: EC:4.3.3.1
xref: MetaCyc:3-KETOVALIDOXYLAMINE-C-N-LYASE-RXN
is_a: GO:0016843 ! amine-lyase activity

[Term]
id: GO:0047567
name: 3-methyleneoxindole reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methyloxindole + NADP+ = 3-methyleneoxindole + NADPH + H+." [EC:1.3.1.17, MetaCyc:3-METHYLENEOXINDOLE-REDUCTASE-RXN]
synonym: "3-methyl-1,3-dihydroindol-2-one:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.17]
synonym: "3-methyloxindole:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.17]
xref: EC:1.3.1.17
xref: MetaCyc:3-METHYLENEOXINDOLE-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047568
name: 3-oxo-5-beta-steroid 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor." [EC:1.3.99.6, MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN]
synonym: "3-oxo-5beta-steroid 4-dehydrogenase activity" EXACT [EC:1.3.99.6]
synonym: "3-oxo-5beta-steroid:(acceptor) delta4-oxidoreductase activity" EXACT [EC:1.3.99.6]
synonym: "3-oxo-5beta-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC:1.3.99.6]
synonym: "delta4-3-ketosteroid 5-beta-reductase activity" EXACT [EC:1.3.99.6]
xref: EC:1.3.99.6
xref: MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN
is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047569
name: 3-oxoadipate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA." [EC:2.8.3.6, MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN]
subset: gosubset_prok
synonym: "3-oxoadipate coenzyme A-transferase activity" EXACT [EC:2.8.3.6]
synonym: "3-oxoadipate succinyl-CoA transferase activity" EXACT [EC:2.8.3.6]
synonym: "beta-ketoadipate:succinyl-CoA transferase activity" EXACT [EC:2.8.3.6]
synonym: "succinyl-CoA:3-oxoadipate CoA-transferase activity" EXACT [EC:2.8.3.6]
xref: EC:2.8.3.6
xref: MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN
xref: UM-BBD_enzymeID:e0654
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047570
name: 3-oxoadipate enol-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate." [EC:3.1.1.24, MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN]
subset: gosubset_prok
synonym: "3-ketoadipate enol-lactonase activity" EXACT [EC:3.1.1.24]
synonym: "3-oxoadipic enol-lactone hydrolase activity" EXACT [EC:3.1.1.24]
synonym: "4-carboxymethylbut-3-en-4-olide enol-lactonohydrolase activity" EXACT [EC:3.1.1.24]
synonym: "beta-ketoadipate enol-lactone hydrolase activity" EXACT [EC:3.1.1.24]
synonym: "beta-ketoadipic enol-lactone hydrolase activity" EXACT [EC:3.1.1.24]
synonym: "carboxymethylbutenolide lactonase activity" EXACT [EC:3.1.1.24]
xref: EC:3.1.1.24
xref: MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047571
name: 3-oxosteroid 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor." [EC:1.3.99.4, MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "1-ene-dehydrogenase activity" EXACT [EC:1.3.99.4]
synonym: "3-ketosteroid-1-en-dehydrogenase activity" EXACT [EC:1.3.99.4]
synonym: "3-ketosteroid-delta1-dehydrogenase activity" EXACT [EC:1.3.99.4]
synonym: "3-oxosteroid delta1-dehydrogenase activity" EXACT [EC:1.3.99.4]
synonym: "3-oxosteroid:(2,6-dichlorphenolindophenol) delta1-oxidoreductase activity" EXACT [EC:1.3.99.4]
synonym: "3-oxosteroid:(acceptor) delta1-oxidoreductase activity" EXACT [EC:1.3.99.4]
synonym: "3-oxosteroid:acceptor delta1-oxidoreductase activity" EXACT [EC:1.3.99.4]
synonym: "4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase activity" EXACT [EC:1.3.99.4]
synonym: "delta1-dehydrogenase activity" EXACT [EC:1.3.99.4]
synonym: "delta1-steroid reductase activity" EXACT [EC:1.3.99.4]
xref: EC:1.3.99.4
xref: MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0712
is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047572
name: 3-phosphoglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glycerate 3-phosphate + H2O = D-glycerate + phosphate." [EC:3.1.3.38, MetaCyc:3-PHOSPHOGLYCERATE-PHOSPHATASE-RXN]
synonym: "3-PGA phosphatase activity" EXACT [EC:3.1.3.38]
synonym: "D-3-phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.38]
synonym: "D-glycerate-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.38]
xref: EC:3.1.3.38
xref: MetaCyc:3-PHOSPHOGLYCERATE-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047573
name: 4-acetamidobutyrate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate." [EC:3.5.1.63, MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN]
synonym: "4-acetamidobutanoate amidohydrolase activity" EXACT [EC:3.5.1.63]
xref: EC:3.5.1.63
xref: MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047574
name: 4-acetamidobutyryl-CoA deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-acetamidobutanoyl + H2O = acetate + 4-aminobutanoyl-CoA." [EC:3.5.1.51, MetaCyc:4-ACETAMIDOBUTYRYL-COA-DEACETYLASE-RXN]
synonym: "4-acetamidobutanoyl-CoA amidohydrolase activity" EXACT [EC:3.5.1.51]
synonym: "aminobutyryl-CoA thiolesterase activity" EXACT [EC:3.5.1.51]
synonym: "deacetylase-thiolesterase activity" EXACT [EC:3.5.1.51]
xref: EC:3.5.1.51
xref: MetaCyc:4-ACETAMIDOBUTYRYL-COA-DEACETYLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047575
name: 4-carboxymuconolactone decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 4,5-dihydro-5-oxofuran-2-acetate + CO2." [EC:4.1.1.44, MetaCyc:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN]
subset: gosubset_prok
synonym: "4-carboxymonolactone carboxy-lyase activity" EXACT [EC:4.1.1.44]
synonym: "4-carboxymuconolactone carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming)" EXACT [EC:4.1.1.44]
synonym: "4-carboxymuconolactone carboxy-lyase activity" EXACT [EC:4.1.1.44]
synonym: "gamma-4-carboxymuconolactone decarboxylase activity" EXACT [EC:4.1.1.44]
xref: EC:4.1.1.44
xref: MetaCyc:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047576
name: 4-chlorobenzoate dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride." [EC:3.8.1.6, MetaCyc:4-CHLOROBENZOATE-DEHALOGENASE-RXN]
synonym: "4-chlorobenzoate chlorohydrolase activity" EXACT [EC:3.8.1.6]
synonym: "halobenzoate dehalogenase activity" EXACT [EC:3.8.1.6]
xref: EC:3.8.1.6
xref: MetaCyc:4-CHLOROBENZOATE-DEHALOGENASE-RXN
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0047577
name: 4-hydroxybutyrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxybutanoate + NAD+ = succinate semialdehyde + NADH + H+." [EC:1.1.1.61, MetaCyc:4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "4-hydroxybutanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.61]
synonym: "gamma-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.61]
xref: EC:1.1.1.61
xref: MetaCyc:4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047578
name: 4-hydroxyglutamate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate." [EC:2.6.1.23, MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN]
synonym: "4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.23]
synonym: "4-hydroxyglutamate aminotransferase activity" EXACT []
xref: EC:2.6.1.23
xref: MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047579
name: 4-hydroxymandelate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2 = 4-hydroxybenzaldehyde + CO2 + H2O2." [EC:1.1.3.19, MetaCyc:4-HYDROXYMANDELATE-OXIDASE-RXN]
synonym: "(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.19]
synonym: "L-4-hydroxymandelate oxidase (decarboxylating)" EXACT [EC:1.1.3.19]
xref: EC:1.1.3.19
xref: MetaCyc:4-HYDROXYMANDELATE-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047580
name: 4-hydroxyproline epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline." [EC:5.1.1.8, MetaCyc:4-HYDROXYPROLINE-EPIMERASE-RXN]
synonym: "4-hydroxyproline 2-epimerase activity" EXACT [EC:5.1.1.8]
synonym: "hydroxyproline 2-epimerase activity" EXACT [EC:5.1.1.8]
synonym: "hydroxyproline epimerase activity" EXACT [EC:5.1.1.8]
synonym: "L-hydroxyproline epimerase activity" EXACT [EC:5.1.1.8]
xref: EC:5.1.1.8
xref: MetaCyc:4-HYDROXYPROLINE-EPIMERASE-RXN
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0047581
name: 4-methyleneglutamate-ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 4-methylene-L-glutamate + NH3 = AMP + diphosphate + 4-methylene-L-glutamine." [EC:6.3.1.7, MetaCyc:4-METHYLENEGLUTAMATE--AMMONIA-LIGASE-RXN]
subset: gosubset_prok
synonym: "4-methylene-L-glutamate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.7]
synonym: "4-methyleneglutamine synthetase activity" EXACT [EC:6.3.1.7]
xref: EC:6.3.1.7
xref: MetaCyc:4-METHYLENEGLUTAMATE--AMMONIA-LIGASE-RXN
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0047582
name: 4-methyleneglutaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH3." [EC:3.5.1.67, MetaCyc:4-METHYLENEGLUTAMINASE-RXN]
synonym: "4-methylene-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.67]
synonym: "4-methyleneglutamine amidohydrolase activity" EXACT [EC:3.5.1.67]
synonym: "4-methyleneglutamine deamidase activity" EXACT [EC:3.5.1.67]
xref: EC:3.5.1.67
xref: MetaCyc:4-METHYLENEGLUTAMINASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047583
name: 4-methyloxaloacetate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxaloacetate 4-methyl ester + H2O = oxaloacetate + methanol." [EC:3.1.1.44, MetaCyc:4-METHYLOXALOACETATE-ESTERASE-RXN]
synonym: "oxaloacetate-4-methyl-ester oxaloacetohydrolase activity" EXACT [EC:3.1.1.44]
xref: EC:3.1.1.44
xref: MetaCyc:4-METHYLOXALOACETATE-ESTERASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047584
name: 4-oxalmesaconate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H2O." [EC:4.2.1.83, MetaCyc:4-OXALMESACONATE-HYDRATASE-RXN]
subset: gosubset_prok
synonym: "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase [(E)-4-oxobut-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.83]
synonym: "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity" EXACT [EC:4.2.1.83]
synonym: "4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity" EXACT [EC:4.2.1.83]
synonym: "4-carboxy-2-oxohexenedioate hydratase activity" EXACT [EC:4.2.1.83]
synonym: "gamma-oxalmesaconate hydratase activity" EXACT [EC:4.2.1.83]
synonym: "oxalmesaconate hydratase activity" EXACT [EC:4.2.1.83]
xref: EC:4.2.1.83
xref: MetaCyc:4-OXALMESACONATE-HYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047585
name: 4-pyridoxolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-pyridoxolactone + H2O = 4-pyridoxate." [EC:3.1.1.27, MetaCyc:4-PYRIDOXOLACTONASE-RXN]
synonym: "4-pyridoxolactone lactonohydrolase activity" EXACT [EC:3.1.1.27]
xref: EC:3.1.1.27
xref: MetaCyc:4-PYRIDOXOLACTONASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047586
name: 5'-acylphosphoadenosine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate." [EC:3.6.1.20, MetaCyc:5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN]
synonym: "5'-acylphosphoadenosine acylhydrolase activity" EXACT [EC:3.6.1.20]
synonym: "5-phosphoadenosine hydrolase activity" EXACT [EC:3.6.1.20]
xref: EC:3.6.1.20
xref: MetaCyc:5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0047587
name: 5-alpha-hydroxysteroid dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-alpha-ergosta-7,22-diene-3-beta,5-diol = ergosterol + H2O." [EC:4.2.1.62, MetaCyc:5-ALPHA-HYDROXYSTEROID-DEHYDRATASE-RXN]
synonym: "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase (ergosterol-forming)" EXACT [EC:4.2.1.62]
synonym: "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase activity" EXACT [EC:4.2.1.62]
synonym: "5alpha-hydroxysteroid dehydratase activity" EXACT [EC:4.2.1.62]
xref: EC:4.2.1.62
xref: MetaCyc:5-ALPHA-HYDROXYSTEROID-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047588
name: 5-aminopentanamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3." [EC:3.5.1.30, MetaCyc:5-AMINOPENTANAMIDASE-RXN]
synonym: "5-aminonorvaleramidase activity" EXACT [EC:3.5.1.30]
synonym: "5-aminopentanamide amidohydrolase activity" EXACT [EC:3.5.1.30]
synonym: "5-aminovaleramidase activity" EXACT [EC:3.5.1.30]
xref: EC:3.5.1.30
xref: MetaCyc:5-AMINOPENTANAMIDASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047589
name: 5-aminovalerate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate." [EC:2.6.1.48, MetaCyc:5-AMINOVALERATE-AMINOTRANSFERASE-RXN]
synonym: "5-aminopentanoate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.48]
synonym: "5-aminovalerate aminotransferase activity" EXACT []
synonym: "delta-aminovalerate aminotransferase activity" EXACT [EC:2.6.1.48]
synonym: "delta-aminovalerate transaminase activity" EXACT [EC:2.6.1.48]
xref: EC:2.6.1.48
xref: MetaCyc:VAGL-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047590
name: 5-dehydro-2-deoxygluconokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate." [EC:2.7.1.92, MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN]
subset: gosubset_prok
synonym: "5-keto-2-deoxyglucono kinase (phosphorylating)" EXACT [EC:2.7.1.92]
synonym: "5-keto-2-deoxygluconokinase activity" EXACT [EC:2.7.1.92]
synonym: "ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.92]
synonym: "DKH kinase activity" EXACT [EC:2.7.1.92]
xref: EC:2.7.1.92
xref: MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047591
name: 5-hydroxypentanoate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + 5-hydroxypentanoate = acetate + 5-hydroxy-pentanoyl-CoA." [EC:2.8.3.14, MetaCyc:5-HYDROXYPENTANOATE-COA-TRANSFERASE-RXN]
synonym: "5-hydroxyvalerate CoA-transferase activity" EXACT [EC:2.8.3.14]
synonym: "5-hydroxyvalerate coenzyme A transferase activity" EXACT [EC:2.8.3.14]
synonym: "acetyl-CoA:5-hydroxypentanoate CoA-transferase activity" EXACT [EC:2.8.3.14]
xref: EC:2.8.3.14
xref: MetaCyc:5-HYDROXYPENTANOATE-COA-TRANSFERASE-RXN
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047592
name: 5-pyridoxate dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate + NADPH + H+ + O2 = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate + NADP+." [EC:1.14.12.5, MetaCyc:5-PYRIDOXATE-DIOXYGENASE-RXN]
synonym: "5-pyridoxate oxidase activity" EXACT [EC:1.14.12.5]
synonym: "5-pyridoxate,NADPH:oxygen oxidoreductase (decyclizing)" EXACT [EC:1.14.12.5]
xref: EC:1.14.12.5
xref: MetaCyc:5-PYRIDOXATE-DIOXYGENASE-RXN
is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

[Term]
id: GO:0047593
name: 6-acetylglucose deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-acetyl-D-glucose + H2O = D-glucose + acetate." [EC:3.1.1.33, MetaCyc:6-ACETYLGLUCOSE-DEACETYLASE-RXN]
synonym: "6-acetyl-D-glucose acetylhydrolase activity" EXACT [EC:3.1.1.33]
synonym: "6-O-acetylglucose deacetylase activity" EXACT [EC:3.1.1.33]
xref: EC:3.1.1.33
xref: MetaCyc:6-ACETYLGLUCOSE-DEACETYLASE-RXN
is_a: GO:0004091 ! carboxylesterase activity
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047594
name: 6-beta-hydroxyhyoscyamine epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = scopolamine + succinate + CO2." [EC:1.14.11.14, MetaCyc:6-BETA-HYDROXYHYOSCYAMINE-EPOXIDASE-RXN]
synonym: "(6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming)" EXACT [EC:1.14.11.14]
synonym: "6beta-hydroxyhyoscyamine epoxidase activity" EXACT [EC:1.14.11.14]
synonym: "hydroxyhyoscyamine dioxygenase activity" EXACT [EC:1.14.11.14]
xref: EC:1.14.11.14
xref: MetaCyc:6-BETA-HYDROXYHYOSCYAMINE-EPOXIDASE-RXN
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0047595
name: 6-hydroxynicotinate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin." [EC:1.3.7.1, MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN]
synonym: "1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.1]
synonym: "6-hydroxynicotinic reductase activity" EXACT [EC:1.3.7.1]
synonym: "6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.1]
synonym: "6-oxotetrahydro-nicotinate dehydrogenase activity" EXACT [EC:1.3.7.1]
synonym: "6-oxotetrahydronicotinate dehydrogenase activity" EXACT [EC:1.3.7.1]
synonym: "HNA reductase activity" EXACT [EC:1.3.7.1]
xref: EC:1.3.7.1
xref: MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0047596
name: 6-methylsalicylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-methylsalicylate = 3-cresol + CO2." [EC:4.1.1.52, MetaCyc:6-METHYLSALICYLATE-DECARBOXYLASE-RXN]
synonym: "6-methylsalicylate carboxy-lyase (3-cresol-forming)" EXACT [EC:4.1.1.52]
synonym: "6-methylsalicylate carboxy-lyase activity" EXACT [EC:4.1.1.52]
synonym: "6-methylsalicylic acid (2,6-cresotic acid) decarboxylase activity" EXACT [EC:4.1.1.52]
synonym: "6-MSA decarboxylase activity" EXACT [EC:4.1.1.52]
xref: EC:4.1.1.52
xref: MetaCyc:6-METHYLSALICYLATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047597
name: 6-oxocineole dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6-oxocineole + NADPH + H+ + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo-[3.2.2]nonan-3-one + NADP+ + H2O." [EC:1.14.13.51, MetaCyc:6-OXOCINEOLE-DEHYDROGENASE-RXN]
synonym: "6-oxocineole oxygenase activity" EXACT [EC:1.14.13.51]
synonym: "6-oxocineole,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.51]
xref: EC:1.14.13.51
xref: MetaCyc:6-OXOCINEOLE-DEHYDROGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047598
name: 7-dehydrocholesterol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+." [EC:1.3.1.21, MetaCyc:7-DEHYDROCHOLESTEROL-REDUCTASE-RXN]
synonym: "7-DHC reductase activity" EXACT [EC:1.3.1.21]
synonym: "cholesterol:NADP+ delta7-oxidoreductase activity" EXACT [EC:1.3.1.21]
synonym: "sterol Delta(7)-reductase activity" BROAD [EC:1.3.1.21]
synonym: "sterol delta7-reductase activity" EXACT [EC:1.3.1.21]
xref: EC:1.3.1.21
xref: MetaCyc:7-DEHYDROCHOLESTEROL-REDUCTASE-RXN
xref: Reactome:78791 "7-dehydrocholesterol reductase activity"
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047599
name: 8-oxocoformycin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: coformycin + NADP+ = 8-oxocoformycin + NADPH + H+." [EC:1.1.1.235, MetaCyc:8-OXOCOFORMYCIN-REDUCTASE-RXN]
synonym: "8-ketodeoxycoformycin reductase activity" EXACT [EC:1.1.1.235]
synonym: "coformycin:NADP+ 8-oxidoreductase activity" EXACT [EC:1.1.1.235]
xref: EC:1.1.1.235
xref: MetaCyc:8-OXOCOFORMYCIN-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047600
name: abequosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid." [EC:2.4.1.60, MetaCyc:ABEQUOSYLTRANSFERASE-RXN]
synonym: "CDP-abequose:D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid D-abequosyltransferase activity" EXACT [EC:2.4.1.60]
synonym: "trihexose diphospholipid abequosyltransferase activity" EXACT [EC:2.4.1.60]
xref: EC:2.4.1.60
xref: MetaCyc:ABEQUOSYLTRANSFERASE-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047601
name: acetate kinase (diphosphate) activity
namespace: molecular_function
def: "Catalysis of the reaction: diphosphate + acetate = phosphate + acetyl phosphate." [EC:2.7.2.12, MetaCyc:ACETATE-KINASE-PYROPHOSPHATE-RXN]
synonym: "acetate kinase (pyrophosphate) activity" EXACT [EC:2.7.2.12]
synonym: "diphosphate:acetate phosphotransferase activity" EXACT [EC:2.7.2.12]
synonym: "pyrophosphate-acetate phosphotransferase activity" EXACT [EC:2.7.2.12]
xref: EC:2.7.2.12
xref: MetaCyc:ACETATE-KINASE-PYROPHOSPHATE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0047602
name: acetoacetate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoacetate + H+ = acetone + CO2." [EC:4.1.1.4, MetaCyc:ACETOACETATE-DECARBOXYLASE-RXN]
subset: gosubset_prok
synonym: "acetoacetate carboxy-lyase (acetone-forming)" EXACT [EC:4.1.1.4]
synonym: "acetoacetate carboxy-lyase activity" EXACT [EC:4.1.1.4]
synonym: "acetoacetic acid decarboxylase activity" EXACT [EC:4.1.1.4]
xref: EC:4.1.1.4
xref: MetaCyc:ACETOACETATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047603
name: acetoacetyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetoacetyl-CoA + H2O = CoA + acetoacetate." [EC:3.1.2.11, MetaCyc:ACETOACETYL-COA-HYDROLASE-RXN]
synonym: "acetoacetyl CoA deacylase activity" EXACT [EC:3.1.2.11]
synonym: "acetoacetyl coenzyme A deacylase activity" EXACT [EC:3.1.2.11]
synonym: "acetoacetyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.11]
xref: EC:3.1.2.11
xref: MetaCyc:ACETOACETYL-COA-HYDROLASE-RXN
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0047604
name: acetoin racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-acetoin = (R)-acetoin." [EC:5.1.2.4, MetaCyc:ACETOIN-RACEMASE-RXN]
synonym: "acetylmethylcarbinol racemase activity" EXACT [EC:5.1.2.4]
xref: EC:5.1.2.4
xref: MetaCyc:ACETOIN-RACEMASE-RXN
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0047605
name: acetolactate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2." [EC:4.1.1.5, MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN]
subset: gosubset_prok
synonym: "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(R)-2-acetoin-forming]" RELATED [EC:4.1.1.5]
synonym: "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase activity" EXACT [EC:4.1.1.5]
synonym: "alpha-acetolactate decarboxylase activity" EXACT [EC:4.1.1.5]
xref: EC:4.1.1.5
xref: MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047606
name: hydroxynitrilase activity
namespace: molecular_function
alt_id: GO:0046991
def: "Catalysis of the reaction: a hydroxynitrile = cyanide + an aldehyde or ketone." [EC:4.1.2, GOC:mah, MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN]
synonym: "(S)-acetone-cyanohydrin lyase activity" NARROW [EC:4.1.2.37]
synonym: "2-hydroxyisobutyronitrile acetone-lyase (cyanide-forming)" NARROW [EC:4.1.2.37]
synonym: "2-hydroxyisobutyronitrile acetone-lyase activity" NARROW [EC:4.1.2.37]
synonym: "acetone-cyanhydrin lyase activity" NARROW [EC:4.1.2.37]
synonym: "acetone-cyanohydrin acetone-lyase (cyanide-forming)" NARROW [EC:4.1.2.37]
synonym: "acetone-cyanohydrin acetone-lyase activity" NARROW [EC:4.1.2.37]
synonym: "acetone-cyanohydrin lyase activity" NARROW [EC:4..1.2.37]
synonym: "alpha-hydroxynitrile lyase activity" NARROW [EC:4.1.2.37]
synonym: "hydroxynitrile lyase activity" EXACT [GOC:curators]
synonym: "oxynitrilase activity" RELATED [EC:4.1.2.37]
xref: EC:4.1.2.37
xref: MetaCyc:4.1.2.39-RXN
xref: MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047608
name: acetylindoxyl oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown." [EC:1.7.3.2, MetaCyc:ACETYLINDOXYL-OXIDASE-RXN]
synonym: "N-acetylindoxyl:oxygen oxidoreductase activity" EXACT [EC:1.7.3.2]
xref: EC:1.7.3.2
xref: MetaCyc:ACETYLINDOXYL-OXIDASE-RXN
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

[Term]
id: GO:0047609
name: acetylputrescine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylputrescine + H2O = acetate + putrescine." [EC:3.5.1.62, MetaCyc:ACETYLPUTRESCINE-DEACETYLASE-RXN]
synonym: "N-acetylputrescine acetylhydrolase activity" EXACT [EC:3.5.1.62]
xref: EC:3.5.1.62
xref: MetaCyc:ACETYLPUTRESCINE-DEACETYLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047610
name: acetylsalicylate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetylsalicylate + H2O = salicylate + acetate." [EC:3.1.1.55, MetaCyc:ACETYLSALICYLATE-DEACETYLASE-RXN]
synonym: "acetylsalicylate O-acetylhydrolase activity" EXACT [EC:3.1.1.55]
synonym: "acetylsalicylic acid esterase activity" EXACT [EC:3.1.1.55]
synonym: "aspirin esterase activity" EXACT [EC:3.1.1.55]
synonym: "aspirin hydrolase activity" EXACT [EC:3.1.1.55]
xref: EC:3.1.1.55
xref: MetaCyc:ACETYLSALICYLATE-DEACETYLASE-RXN
is_a: GO:0004091 ! carboxylesterase activity
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047611
name: acetylspermidine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N1-acetylspermidine + H2O = acetate + spermidine." [EC:3.5.1.48, MetaCyc:ACETYLSPERMIDINE-DEACETYLASE-RXN]
subset: gosubset_prok
synonym: "8-N-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48]
synonym: "N(1)-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48]
synonym: "N(8)-acetylspermidine amidohydrolase activity" RELATED [EC:3.5.1.48]
synonym: "N(8)-acetylspermidine deacetylase activity" RELATED [EC:3.5.1.48]
synonym: "N(8)-monoacetylspermidine deacetylase activity" RELATED [EC:3.5.1.48]
synonym: "N-acetylspermidine deacetylase activity" BROAD [EC:3.5.1.48]
synonym: "N1-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48]
synonym: "N8-acetylspermidine amidohydrolase activity" EXACT [EC:3.5.1.48]
synonym: "N8-acetylspermidine deacetylase activity" EXACT [EC:3.5.1.48]
synonym: "N8-monoacetylspermidine deacetylase activity" EXACT [EC:3.5.1.48]
xref: EC:3.5.1.48
xref: MetaCyc:ACETYLSPERMIDINE-DEACETYLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047612
name: acid-CoA ligase (GDP-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + an acid + CoA = GDP + phosphate + acyl-CoA." [EC:6.2.1.10, MetaCyc:ACID--COA-LIGASE-GDP-FORMING-RXN]
synonym: "acid:CoA ligase (GDP-forming)" EXACT [EC:6.2.1.10]
synonym: "acyl coenzyme A synthetase (guanosine diphosphate forming)" EXACT [EC:6.2.1.10]
synonym: "acyl-CoA synthetase (GDP-forming) activity" EXACT [EC:6.2.1.10]
xref: EC:6.2.1.10
xref: MetaCyc:ACID--COA-LIGASE-GDP-FORMING-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047613
name: aconitate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-aconitate = itaconate + CO2." [EC:4.1.1.6, MetaCyc:ACONITATE-DECARBOXYLASE-RXN]
synonym: "CAD activity" BROAD [EC:4.1.1.6]
synonym: "cis-aconitate carboxy-lyase (itaconate-forming)" EXACT [EC:4.1.1.6]
synonym: "cis-aconitate carboxy-lyase activity" EXACT [EC:4.1.1.6]
synonym: "cis-aconitic decarboxylase activity" EXACT [EC:4.1.1.6]
xref: EC:4.1.1.6
xref: MetaCyc:ACONITATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047614
name: aconitate delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-aconitate = cis-aconitate." [EC:5.3.3.7, MetaCyc:ACONITATE-DELTA-ISOMERASE-RXN]
synonym: "aconitate D-isomerase activity" EXACT []
synonym: "aconitate delta2-delta3-isomerase activity" EXACT [EC:5.3.3.7]
synonym: "aconitate isomerase activity" BROAD [EC:5.3.3.7]
xref: EC:5.3.3.7
xref: MetaCyc:ACONITATE-DELTA-ISOMERASE-RXN
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0047615
name: actinomycin lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone." [EC:3.1.1.39, MetaCyc:ACTINOMYCIN-LACTONASE-RXN]
synonym: "actinomycin lactonohydrolase activity" EXACT [EC:3.1.1.39]
xref: EC:3.1.1.39
xref: MetaCyc:ACTINOMYCIN-LACTONASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047616
name: acyl-CoA dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.8, MetaCyc:ACYL-COA-DEHYDROGENASE-NADP+-RXN]
synonym: "2-enoyl-CoA reductase activity" EXACT [EC:1.3.1.8]
synonym: "acyl-CoA:NADP+ 2-oxidoreductase activity" EXACT [EC:1.3.1.8]
synonym: "crotonyl coenzyme A reductase activity" EXACT [EC:1.3.1.8]
synonym: "dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.8]
synonym: "enoyl coenzyme A reductase activity" EXACT [EC:1.3.1.8]
xref: EC:1.3.1.8
xref: MetaCyc:ACYL-COA-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047617
name: acyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate." [EC:3.1.2.20, MetaCyc:ACYL-COA-HYDROLASE-RXN]
subset: gosubset_prok
synonym: "acyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.20]
synonym: "acyl coenzyme A thioesterase activity" EXACT [EC:3.1.2.20]
synonym: "thioesterase B" RELATED [EC:3.1.2.20]
synonym: "thioesterase II" RELATED [EC:3.1.2.20]
xref: EC:3.1.2.20
xref: MetaCyc:ACYL-COA-HYDROLASE-RXN
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0047618
name: acylagmatine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoylagmatine + H2O = benzoate + agmatine." [EC:3.5.1.40, MetaCyc:ACYLAGMATINE-AMIDASE-RXN]
synonym: "acylagmatine amidohydrolase activity" EXACT [EC:3.5.1.40]
synonym: "acylagmatine deacylase activity" EXACT [EC:3.5.1.40]
synonym: "benzoylagmatine amidohydrolase activity" EXACT [EC:3.5.1.40]
xref: EC:3.5.1.40
xref: MetaCyc:ACYLAGMATINE-AMIDASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047619
name: acylcarnitine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine." [EC:3.1.1.28, MetaCyc:ACYLCARNITINE-HYDROLASE-RXN]
synonym: "carnitine ester hydrolase activity" EXACT [EC:3.1.1.28]
synonym: "HACH" RELATED [EC:3.1.1.28]
synonym: "high activity acylcarnitine hydrolase activity" EXACT [EC:3.1.1.28]
synonym: "long-chain acyl-L-carnitine hydrolase activity" EXACT [EC:3.1.1.28]
synonym: "O-acylcarnitine acylhydrolase activity" EXACT [EC:3.1.1.28]
synonym: "palmitoyl carnitine hydrolase activity" EXACT [EC:3.1.1.28]
synonym: "palmitoyl-L-carnitine hydrolase activity" EXACT [EC:3.1.1.28]
synonym: "palmitoylcarnitine hydrolase activity" EXACT [EC:3.1.1.28]
xref: EC:3.1.1.28
xref: MetaCyc:ACYLCARNITINE-HYDROLASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047620
name: acylglycerol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate." [EC:2.7.1.94, MetaCyc:ACYLGLYCEROL-KINASE-RXN]
synonym: "ATP:acylglycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.94]
synonym: "MGK" RELATED [EC:2.7.1.94]
synonym: "monoacylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.94]
synonym: "monoacylglycerol kinase activity" EXACT [EC:2.7.1.94]
synonym: "monoglyceride kinase activity" EXACT [EC:2.7.1.94]
synonym: "monoglyceride phosphokinase activity" EXACT [EC:2.7.1.94]
synonym: "sn-2-monoacylglycerol kinase activity" EXACT [EC:2.7.1.94]
xref: EC:2.7.1.94
xref: MetaCyc:ACYLGLYCEROL-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047621
name: acylpyruvate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate." [EC:3.7.1.5, MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN]
subset: gosubset_prok
synonym: "3-acylpyruvate acylhydrolase activity" EXACT [EC:3.7.1.5]
xref: EC:3.7.1.5
xref: MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN
xref: UM-BBD_enzymeID:e0868
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0047622
name: adenosine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine + H2O = D-ribose + adenine." [EC:3.2.2.7, MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN]
synonym: "adenosinase activity" EXACT [EC:3.2.2.7]
synonym: "adenosine hydrolase activity" EXACT [EC:3.2.2.7]
synonym: "adenosine ribohydrolase activity" EXACT [EC:3.2.2.7]
synonym: "ANase activity" EXACT [EC:3.2.2.7]
synonym: "N-ribosyladenine ribohydrolase activity" EXACT [EC:3.2.2.7]
xref: EC:3.2.2.7
xref: MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047623
name: adenosine-phosphate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-AMP + H2O = 5'-IMP + NH3." [EC:3.5.4.17, MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN]
synonym: "adenine nucleotide deaminase activity" EXACT [EC:3.5.4.17]
synonym: "adenosine (phosphate) deaminase activity" EXACT [EC:3.5.4.17]
synonym: "adenosine-phosphate aminohydrolase activity" EXACT [EC:3.5.4.17]
xref: EC:3.5.4.17
xref: MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047624
name: adenosine-tetraphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate." [EC:3.6.1.14, MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN]
subset: gosubset_prok
synonym: "adenosine-tetraphosphate phosphohydrolase activity" EXACT [EC:3.6.1.14]
xref: EC:3.6.1.14
xref: MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047625
name: adenosylmethionine cyclotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine = 5'-methylthioadenosine + 2-aminobutan-4-olide." [EC:2.5.1.4, MetaCyc:ADENOSYLMETHIONINE-CYCLOTRANSFERASE-RXN]
synonym: "adenosyl methionine cyclotransferase activity" EXACT []
synonym: "adenosylmethioninase activity" EXACT [EC:2.5.1.4]
synonym: "S-adenosyl-L-methionine alkyltransferase (cyclizing)" EXACT [EC:2.5.1.4]
xref: EC:2.5.1.4
xref: MetaCyc:ADENOSYLMETHIONINE-CYCLOTRANSFERASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047626
name: adenosylmethionine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + S-adenosyl-L-methionine = L-homoserine + methylthioadenosine." [EC:3.3.1.2, MetaCyc:ADENOSYLMETHIONINE-HYDROLASE-RXN]
synonym: "adenosyl methionine hydrolase activity" EXACT []
synonym: "adenosylmethionine lyase activity" EXACT [EC:3.3.1.2]
synonym: "methylmethionine-sulfonium-salt hydrolase activity" EXACT [EC:3.3.1.2]
synonym: "S-adenosyl-L-methionine hydrolase activity" EXACT [EC:3.3.1.2]
synonym: "S-adenosylmethionine cleaving enzyme activity" EXACT [EC:3.3.1.2]
xref: EC:3.3.1.2
xref: MetaCyc:ADENOSYLMETHIONINE-HYDROLASE-RXN
is_a: GO:0016802 ! trialkylsulfonium hydrolase activity

[Term]
id: GO:0047627
name: adenylylsulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenylylsulfate + H2O = AMP + SO4(2-) (sulfate)." [EC:3.6.2.1, MetaCyc:ADENYLYLSULFATASE-RXN]
synonym: "adenosine 5-phosphosulfate sulfohydrolase activity" EXACT [EC:3.6.2.1]
synonym: "adenylylsulfate sulfohydrolase activity" EXACT [EC:3.6.2.1]
synonym: "adenylylsulphatase activity" EXACT []
xref: EC:3.6.2.1
xref: MetaCyc:ADENYLYLSULFATASE-RXN
is_a: GO:0016819 ! hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides

[Term]
id: GO:0047628
name: ADP-thymidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + thymidine = AMP + thymidine 5'-phosphate." [EC:2.7.1.118, MetaCyc:ADP--THYMIDINE-KINASE-RXN]
synonym: "adenosine diphosphate-thymidine phosphotransferase activity" EXACT [EC:2.7.1.118]
synonym: "ADP:dThd phosphotransferase activity" EXACT [EC:2.7.1.118]
synonym: "ADP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.118]
xref: EC:2.7.1.118
xref: MetaCyc:ADP--THYMIDINE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047629
name: ADP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP + H2O = IDP + NH3." [EC:3.5.4.7, MetaCyc:ADP-DEAMINASE-RXN]
synonym: "adenosine diphosphate deaminase activity" EXACT [EC:3.5.4.7]
synonym: "adenosinepyrophosphate deaminase activity" EXACT [EC:3.5.4.7]
synonym: "ADP aminohydrolase activity" EXACT [EC:3.5.4.7]
xref: EC:3.5.4.7
xref: MetaCyc:ADP-DEAMINASE-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047630
name: ADP-phosphoglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(ADP)-2-phosphoglycerate + H2O = 3-(ADP)-glycerate + phosphate." [EC:3.1.3.28, MetaCyc:ADP-PHOSPHOGLYCERATE-PHOSPHATASE-RXN]
synonym: "3-(ADP)-2-phosphoglycerate phosphohydrolase activity" EXACT [EC:3.1.3.28]
synonym: "adenosine diphosphate phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.28]
synonym: "ADPphosphoglycerate phosphatase activity" EXACT [EC:3.1.3.28]
xref: EC:3.1.3.28
xref: MetaCyc:ADP-PHOSPHOGLYCERATE-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047631
name: ADP-ribose diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate." [EC:3.6.1.13, MetaCyc:ADP-RIBOSE-PYROPHOSPHATASE-RXN]
subset: gosubset_prok
synonym: "adenosine diphosphoribose pyrophosphatase activity" EXACT []
synonym: "ADP-ribose phosphohydrolase activity" EXACT []
synonym: "ADP-ribose pyrophosphatase activity" EXACT []
synonym: "ADP-ribose ribophosphohydrolase activity" EXACT [EC:3.6.1.13]
synonym: "ADPR-PPase activity" EXACT []
synonym: "ADPribose diphosphatase activity" EXACT [EC:3.6.1.13]
synonym: "ADPribose pyrophosphatase activity" EXACT [EC:3.6.1.13]
xref: EC:3.6.1.13
xref: MetaCyc:RXN0-1441
is_a: GO:0019144 ! ADP-sugar diphosphatase activity

[Term]
id: GO:0047632
name: agmatine deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3." [EC:3.5.3.12, MetaCyc:AGMATINE-DEIMINASE-RXN]
subset: gosubset_prok
synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.12]
synonym: "agmatine iminohydrolase activity" EXACT [EC:3.5.3.12]
xref: EC:3.5.3.12
xref: MetaCyc:AGMATINE-DEIMINASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047633
name: agmatine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + agmatine = ADP + N4-phosphoagmatine." [EC:2.7.3.10, MetaCyc:AGMATINE-KINASE-RXN]
synonym: "ATP:agmatine 4-N-phosphotransferase activity" EXACT [EC:2.7.3.10]
synonym: "ATP:agmatine N4-phosphotransferase activity" EXACT [EC:2.7.3.10]
synonym: "phosphagen phosphokinase activity" RELATED [EC:2.7.3.10]
xref: EC:2.7.3.10
xref: MetaCyc:AGMATINE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0047634
name: agmatine N4-coumaroyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = CoA + N-(4-guanidinobutyl)-N4-hydroxycinnamamide." [EC:2.3.1.64, MetaCyc:AGMATINE-N4-COUMAROYLTRANSFERASE-RXN]
synonym: "4-coumaroyl-CoA:agmatine 4-N-coumaroyltransferase activity" EXACT [EC:2.3.1.64]
synonym: "4-coumaroyl-CoA:agmatine N4-coumaroyltransferase activity" EXACT [EC:2.3.1.64]
synonym: "agmatine coumaroyltransferase activity" EXACT [EC:2.3.1.64]
synonym: "p-coumaroyl-CoA-agmatine N-p-coumaroyltransferase activity" EXACT [EC:2.3.1.64]
xref: EC:2.3.1.64
xref: MetaCyc:AGMATINE-N4-COUMAROYLTRANSFERASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047635
name: alanine-oxo-acid transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid." [EC:2.6.1.12, MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN]
subset: gosubset_prok
synonym: "alanine--oxo-acid aminotransferase activity" EXACT [EC:2.6.1.12]
synonym: "alanine-keto acid aminotransferase activity" EXACT [EC:2.6.1.12]
synonym: "alanine-oxo acid aminotransferase activity" EXACT [EC:2.6.1.12]
synonym: "alanine-oxo-acid aminotransferase activity" EXACT []
synonym: "L-alanine-alpha-keto acid aminotransferase activity" EXACT [EC:2.6.1.12]
synonym: "L-alanine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.12]
synonym: "leucine-alanine transaminase activity" EXACT [EC:2.6.1.12]
xref: EC:2.6.1.12
xref: MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047636
name: alanopine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,2'-iminodipropanoate + NAD+ + H2O = L-alanine + pyruvate + NADH." [EC:1.5.1.17, MetaCyc:ALANOPINE-DEHYDROGENASE-RXN]
synonym: "2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)" EXACT [EC:1.5.1.17]
synonym: "ADH" RELATED [EC:1.5.1.17]
synonym: "alanopine: NAD oxidoreductase activity" EXACT [EC:1.5.1.17]
synonym: "alanopine:NAD oxidoreductase activity" EXACT [EC:1.5.1.17]
synonym: "alanopine[meso-N-(1-carboxyethyl)-alanine]dehydrogenase activity" EXACT [EC:1.5.1.17]
synonym: "ALPDH" RELATED [EC:1.5.1.17]
synonym: "meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.17]
xref: EC:1.5.1.17
xref: MetaCyc:ALANOPINE-DEHYDROGENASE-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047637
name: alanylphosphatidylglycerol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-alanyl-tRNA + phosphatidylglycerol = tRNA + 3-O-L-alanyl-1-O-phosphatidylglycerol." [EC:2.3.2.11, MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN]
synonym: "alanyl phosphatidylglycerol synthetase activity" EXACT [EC:2.3.2.11]
synonym: "L-alanyl-tRNA:phosphatidylglycerol alanyltransferase activity" EXACT [EC:2.3.2.11]
synonym: "O-alanylphosphatidylglycerol synthase activity" EXACT [EC:2.3.2.11]
xref: EC:2.3.2.11
xref: MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0047638
name: albendazole monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: albendazole + NADPH + O2 = albendazole S-oxide + NADP+ + H2O." [EC:1.14.13.32, MetaCyc:ALBENDAZOLE-MONOOXYGENASE-RXN]
synonym: "albendazole oxidase activity" EXACT [EC:1.14.13.32]
synonym: "albendazole sulfoxidase activity" EXACT [EC:1.14.13.32]
synonym: "albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)" EXACT [EC:1.14.13.32]
xref: EC:1.14.13.32
xref: MetaCyc:ALBENDAZOLE-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047639
name: alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2." [EC:1.1.3.13, MetaCyc:ALCOHOL-OXIDASE-RXN]
comment: Note that the enzyme alcohol oxidase also has methanol oxidase activity (GO:0046563).
synonym: "alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.13]
synonym: "AOX activity" EXACT [EC:1.1.3.13]
synonym: "ethanol oxidase activity" EXACT [EC:1.1.3.13]
xref: EC:1.1.3.13
xref: MetaCyc:ALCOHOL-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047640
name: aldose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-aldose + NAD+ = D-aldonolactone + NADH." [EC:1.1.1.121, MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN]
synonym: "aldose dehydrogenase activity" EXACT [EC:1.1.1.121]
synonym: "D-aldose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.121]
synonym: "dehydrogenase, D-aldohexose" EXACT [EC:1.1.1.121]
xref: EC:1.1.1.121
xref: MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047641
name: aldose-6-phosphate reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-sorbitol 6-phosphate + NADP+ = D-glucose 6-phosphate + NADPH." [EC:1.1.1.200, MetaCyc:ALDOSE-6-PHOSPHATE-REDUCTASE-NADPH-RXN]
synonym: "A6PR" RELATED [EC:1.1.1.200]
synonym: "alditol 6-phosphate:NADP 1-oxidoreductase activity" EXACT [EC:1.1.1.200]
synonym: "aldose 6-phosphate reductase activity" EXACT [EC:1.1.1.200]
synonym: "aldose-6-P reductase activity" EXACT [EC:1.1.1.200]
synonym: "aldose-6-phosphate reductase activity" EXACT [EC:1.1.1.200]
synonym: "D-aldose-6-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.200]
synonym: "NADP-dependent aldose 6-phosphate reductase activity" EXACT [EC:1.1.1.200]
synonym: "NADP-dependent D-sorbitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.200]
xref: EC:1.1.1.200
xref: MetaCyc:ALDOSE-6-PHOSPHATE-REDUCTASE-NADPH-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047642
name: aldose beta-D-fructosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside." [EC:2.4.1.162, MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN]
synonym: "aldose b-D-fructosyltransferase activity" EXACT []
synonym: "alpha-D-aldosyl-beta-D-fructoside:aldose 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.162]
xref: EC:2.4.1.162
xref: MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN
is_a: GO:0050738 ! fructosyltransferase activity

[Term]
id: GO:0047643
name: alginate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-D-mannuronate + alginate(n) = GDP + alginate(n+1)." [EC:2.4.1.33, MetaCyc:ALGINATE-SYNTHASE-RXN]
synonym: "GDP-D-mannuronate:alginate D-mannuronyltransferase activity" EXACT [EC:2.4.1.33]
synonym: "mannuronosyl transferase activity" EXACT [EC:2.4.1.33]
xref: EC:2.4.1.33
xref: MetaCyc:ALGINATE-SYNTHASE-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047644
name: alizarin 2-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + alizarin = UDP + 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone." [EC:2.4.1.103, MetaCyc:ALIZARIN-2-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "alizarin 2-b-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.103]
synonym: "UDPglucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyl-transferase activity" EXACT [EC:2.4.1.103]
synonym: "uridine diphosphoglucose-alizarin glucosyltransferase activity" EXACT [EC:2.4.1.103]
xref: EC:2.4.1.103
xref: MetaCyc:ALIZARIN-2-BETA-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047645
name: alkan-1-ol dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor." [EC:1.1.99.20, MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN]
synonym: "alkan-1-ol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.20]
synonym: "alkan-1-ol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.20]
synonym: "polyethylene glycol dehydrogenase activity" NARROW [EC:1.1.99.20]
xref: EC:1.1.99.20
xref: MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047646
name: alkanal monooxygenase (FMN-linked) activity
namespace: molecular_function
def: "Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light." [EC:1.14.14.3, MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN]
subset: gosubset_prok
synonym: "aldehyde monooxygenase activity" BROAD [EC:1.14.14.3]
synonym: "alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing)" EXACT [EC:1.14.14.3]
synonym: "bacterial luciferase activity" EXACT [EC:1.14.14.3]
synonym: "vibrio fischeri luciferase activity" EXACT [EC:1.14.14.3]
xref: EC:1.14.14.3
xref: MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047647
name: alkylacetylglycerophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycero-3-phosphate + H2O = 1-alkyl-2-acetyl-sn-glycerol + phosphate." [EC:3.1.3.59, MetaCyc:ALKYLACETYLGLYCEROPHOSPHATASE-RXN]
synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.59]
synonym: "1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase activity" EXACT [EC:3.1.3.59]
synonym: "alkylacetylglycerophosphate phosphatase activity" EXACT [EC:3.1.3.59]
xref: EC:3.1.3.59
xref: MetaCyc:ALKYLACETYLGLYCEROPHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047648
name: alkylamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methylhexanamide + H2O = hexanoate + methylamine." [EC:3.5.1.39, MetaCyc:ALKYLAMIDASE-RXN]
synonym: "N-methylhexanamide amidohydrolase activity" EXACT [EC:3.5.1.39]
xref: EC:3.5.1.39
xref: MetaCyc:ALKYLAMIDASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047649
name: alkylglycerol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1-O-alkyl-sn-glycerol = ADP + 1-O-alkyl-sn-glycerol 3-phosphate." [EC:2.7.1.93, MetaCyc:ALKYLGLYCEROL-KINASE-RXN]
synonym: "1-alkylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.93]
synonym: "alkylglycerol phosphotransferase activity" EXACT [EC:2.7.1.93]
synonym: "ATP-alkylglycerol phosphotransferase activity" EXACT [EC:2.7.1.93]
synonym: "ATP:1-alkyl-sn-glycerol phosphotransferase activity" EXACT [EC:2.7.1.93]
synonym: "ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.93]
xref: EC:2.7.1.93
xref: MetaCyc:ALKYLGLYCEROL-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047650
name: alkylglycerone kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + O-alkylglycerone = ADP + O-alkylglycerone phosphate." [EC:2.7.1.84, MetaCyc:ALKYLGLYCERONE-KINASE-RXN]
synonym: "alkyldihydroxyacetone kinase (phosphorylating)" EXACT [EC:2.7.1.84]
synonym: "alkyldihydroxyacetone kinase activity" EXACT [EC:2.7.1.84]
synonym: "ATP:O-alkylglycerone phosphotransferase activity" EXACT [EC:2.7.1.84]
xref: EC:2.7.1.84
xref: MetaCyc:ALKYLGLYCERONE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047651
name: alkylhalidase activity
namespace: molecular_function
def: "Catalysis of the reaction: bromochloromethane + H2O = formaldehyde + bromide + chloride." [EC:3.8.1.1, MetaCyc:ALKYLHALIDASE-RXN]
subset: gosubset_prok
synonym: "alkyl-halide halidohydrolase activity" EXACT [EC:3.8.1.1]
synonym: "haloalkane halidohydrolase activity" EXACT [EC:3.8.1.1]
synonym: "halogenase activity" RELATED [EC:3.8.1.1]
xref: EC:3.8.1.1
xref: MetaCyc:ALKYLHALIDASE-RXN
is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds

[Term]
id: GO:0047652
name: allantoate deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: allantoate + H2O + H+ = CO2 + NH3 + ureidoglycine." [EC:3.5.3.9, MetaCyc:ALLANTOATE-DEIMINASE-RXN]
synonym: "allantoate amidinohydrolase (decarboxylating)" EXACT [EC:3.5.3.9]
synonym: "allantoate amidohydrolase activity" EXACT [EC:3.5.3.9]
xref: EC:3.5.3.9
xref: MetaCyc:ALLANTOATE-DEIMINASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047653
name: allantoin racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)(+)-allantoin = (R)(-)-allantoin." [EC:5.1.99.3, MetaCyc:ALLANTOIN-RACEMASE-RXN]
xref: EC:5.1.99.3
xref: MetaCyc:ALLANTOIN-RACEMASE-RXN
is_a: GO:0016854 ! racemase and epimerase activity

[Term]
id: GO:0047654
name: alliin lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate." [EC:4.4.1.4, MetaCyc:ALLIIN-LYASE-RXN]
synonym: "alkylcysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4]
synonym: "alliin alkyl-sulfenate-lyase activity" EXACT [EC:4.4.1.4]
synonym: "alliinase activity" EXACT [EC:4.4.1.4]
synonym: "cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4]
synonym: "cysteine sulphoxide lyase activity" EXACT [EC:4.4.1.4]
synonym: "L-cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4]
synonym: "S-alkyl-L-cysteine S-oxide alkyl-sulfenate-lyase (2-aminoacrylate-forming)" EXACT [EC:4.4.1.4]
synonym: "S-alkylcysteine sulfoxide lyase activity" EXACT [EC:4.4.1.4]
xref: EC:4.4.1.4
xref: MetaCyc:ALLIIN-LYASE-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0047655
name: allyl-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: allyl alcohol + NADP+ = acrolein + NADPH." [EC:1.1.1.54, MetaCyc:ALLYL-ALCOHOL-DEHYDROGENASE-RXN]
synonym: "allyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.54]
xref: EC:1.1.1.54
xref: MetaCyc:ALLYL-ALCOHOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047656
name: alpha,alpha-trehalose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.64, MetaCyc:ALPHAALPHA-TREHALOSE-PHOSPHORYLASE-RXN]
subset: gosubset_prok
synonym: "a,a-trehalose phosphorylase activity" EXACT []
synonym: "alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.64]
synonym: "trehalose phosphorylase" BROAD [EC:2.4.1.64]
xref: EC:2.4.1.64
xref: MetaCyc:ALPHAALPHA-TREHALOSE-PHOSPHORYLASE-RXN
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0047657
name: alpha-1,3-glucan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + [alpha-D-glucosyl-(1,3)]n = UDP + [alpha-D-glucosyl-(1,3)]n+1." [EC:2.4.1.183, MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN]
synonym: "1,3-alpha-D-glucan synthase activity" EXACT [EC:2.4.1.183]
synonym: "1,3-alpha-glucan synthase activity" EXACT []
synonym: "a-1,3-glucan synthase activity" EXACT []
synonym: "UDP-glucose:alpha-D-(1-3)-glucan 3-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.183]
synonym: "UDPglucose:alpha-D-(1-3)-glucan 3-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.183]
synonym: "uridine diphosphoglucose-1,3-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.183]
xref: EC:2.4.1.183
xref: MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047658
name: alpha-amino-acid esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol." [EC:3.1.1.43, MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN]
subset: gosubset_prok
synonym: "a-amino-acid esterase activity" EXACT []
synonym: "alpha-amino acid ester hydrolase activity" EXACT [EC:3.1.1.43]
synonym: "alpha-amino-acid ester hydrolase activity" EXACT [EC:3.1.1.43]
synonym: "alpha-amino-acid-ester aminoacylhydrolase activity" EXACT [EC:3.1.1.43]
xref: EC:3.1.1.43
xref: MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047659
name: alpha-santonin 1,2-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+." [EC:1.3.1.47, MetaCyc:ALPHA-SANTONIN-12-REDUCTASE-RXN]
synonym: "1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase activity" EXACT [EC:1.3.1.47]
synonym: "a-santonin 1,2-reductase activity" EXACT []
xref: EC:1.3.1.47
xref: MetaCyc:ALPHA-SANTONIN-12-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047660
name: amidinoaspartase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-amidino-L-aspartate + H2O = L-aspartate + urea." [EC:3.5.3.14, MetaCyc:AMIDINOASPARTASE-RXN]
synonym: "amidinoaspartic amidinohydrolase activity" EXACT [EC:3.5.3.14]
synonym: "N-amidino-L-aspartate amidinohydrolase activity" EXACT [EC:3.5.3.14]
xref: EC:3.5.3.14
xref: MetaCyc:AMIDINOASPARTASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047661
name: amino-acid racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: an L-amino acid = a D-amino acid." [EC:5.1.1.10, MetaCyc:AMINO-ACID-RACEMASE-RXN]
subset: gosubset_prok
synonym: "L-amino acid racemase activity" EXACT [EC:5.1.1.10]
xref: EC:5.1.1.10
xref: MetaCyc:AMINO-ACID-RACEMASE-RXN
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives

[Term]
id: GO:0047662
name: aminobenzoate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2." [EC:4.1.1.24, MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN]
synonym: "aminobenzoate carboxy-lyase (aniline-forming)" EXACT [EC:4.1.1.24]
synonym: "aminobenzoate carboxy-lyase activity" EXACT [EC:4.1.1.24]
xref: EC:4.1.1.24
xref: MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047663
name: aminoglycoside 6'-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 6'-N-acetylaminoglycoside. This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring." [GOC:cb]
subset: gosubset_prok
synonym: "6'-aminoglycoside-N-acetyltransferase activity" EXACT [EC:2.3.1.82]
synonym: "AAC(6') activity" RELATED [EC:2.3.1.82]
synonym: "acetyl-CoA:kanamycin-B N6'-acetyltransferase activity" NARROW [EC:2.3.1.82]
synonym: "aminoglycoside N6'-acetyltransferase activity" EXACT []
synonym: "aminoglycoside-6'-acetyltransferase activity" EXACT [EC:2.3.1.82]
synonym: "aminoglycoside-6-N-acetyltransferase activity" EXACT [EC:2.3.1.82]
synonym: "kanamycin 6'-N-acetyltransferase activity" NARROW []
xref: EC:2.3.1.82
xref: MetaCyc:AMINOGLYCOSIDE-N6-ACETYLTRANSFERASE-RXN
is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity

[Term]
id: GO:0047664
name: aminoimidazolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminoimidazole + H2O = unidentified product + NH3." [EC:3.5.4.8, MetaCyc:AMINOIMIDAZOLASE-RXN]
synonym: "4-aminoimidazole aminohydrolase activity" EXACT [EC:3.5.4.8]
synonym: "4-aminoimidazole hydrolase activity" EXACT [EC:3.5.4.8]
xref: EC:3.5.4.8
xref: MetaCyc:R13-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

[Term]
id: GO:0047665
name: aminolevulinate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine." [EC:2.6.1.43, MetaCyc:AMINOLEVULINATE-AMINOTRANSFERASE-RXN]
synonym: "4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43]
synonym: "4,5-dioxovaleric acid aminotransferase activity" EXACT [EC:2.6.1.43]
synonym: "4,5-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43]
synonym: "4,5-dioxovaleric transaminase activity" EXACT [EC:2.6.1.43]
synonym: "5-aminolevulinate:pyruvate aminotransferase activity" EXACT [EC:2.6.1.43]
synonym: "5-aminolevulinic acid transaminase activity" EXACT [EC:2.6.1.43]
synonym: "alanine-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43]
synonym: "alanine-gamma,delta-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43]
synonym: "alanine:4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43]
synonym: "aminolevulinate aminotransferase activity" EXACT []
synonym: "aminolevulinic acid transaminase activity" EXACT [EC:2.6.1.43]
synonym: "dioxovalerate transaminase activity" EXACT [EC:2.6.1.43]
synonym: "DOVA transaminase activity" EXACT [EC:2.6.1.43]
synonym: "gamma,delta-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43]
synonym: "gamma,delta-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43]
synonym: "L-alanine-4,5-dioxovalerate aminotransferase activity" EXACT [EC:2.6.1.43]
synonym: "L-alanine:4,5-dioxovaleric acid transaminase activity" EXACT [EC:2.6.1.43]
synonym: "L-alanine:dioxovalerate transaminase activity" EXACT [EC:2.6.1.43]
xref: EC:2.6.1.43
xref: MetaCyc:AMINOLEVULINATE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047666
name: ammonia kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + NH3 = ADP + phosphoramide." [EC:2.7.3.8, MetaCyc:AMMONIA-KINASE-RXN]
synonym: "ATP:ammonia phosphotransferase activity" EXACT [EC:2.7.3.8]
synonym: "phosphoramidate-adenosine diphosphate phosphotransferase activity" EXACT [EC:2.7.3.8]
synonym: "phosphoramidate-ADP-phosphotransferase activity" EXACT [EC:2.7.3.8]
xref: EC:2.7.3.8
xref: MetaCyc:AMMONIA-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0047667
name: AMP-thymidine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate." [EC:2.7.1.114, MetaCyc:AMP--THYMIDINE-KINASE-RXN]
synonym: "adenylate-nucleoside phosphotransferase activity" EXACT [EC:2.7.1.114]
synonym: "adenylic acid:deoxythymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114]
synonym: "AMP:deoxythymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114]
synonym: "AMP:deoxythymidine kinase activity" EXACT [EC:2.7.1.114]
synonym: "AMP:dThd kinase activity" EXACT [EC:2.7.1.114]
synonym: "AMP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.114]
synonym: "thymidine phosphotransferase activity" EXACT [EC:2.7.1.114]
xref: EC:2.7.1.114
xref: MetaCyc:AMP--THYMIDINE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047668
name: amygdalin beta-glucosidase activity
namespace: molecular_function
alt_id: GO:0080080
def: "Catalysis of the reaction: (R)-amygdalin + H2O = (R)-prunasin + D-glucose." [EC:3.2.1.117, MetaCyc:AMYGDALIN-BETA-GLUCOSIDASE-RXN]
synonym: "(R)-amygdalin beta-glucosidase activity" EXACT []
synonym: "amygdalin b-glucosidase activity" EXACT []
synonym: "amygdalin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.117]
synonym: "amygdalin glucosidase activity" EXACT [EC:3.2.1.117]
synonym: "amygdalin hydrolase activity" EXACT [EC:3.2.1.117]
synonym: "amygdalinase" BROAD [EC:3.2.1.117]
xref: EC:3.2.1.117
xref: MetaCyc:AMYGDALIN-BETA-GLUCOSIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047669
name: amylosucrase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + 1,4-alpha-D-glucosyl(n) = D-fructose + 1,4-alpha-D-glucosyl(n+1)." [EC:2.4.1.4, MetaCyc:AMYLOSUCRASE-RXN]
subset: gosubset_prok
synonym: "sucrose-1,4-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.4]
synonym: "sucrose-glucan glucosyltransferase activity" EXACT [EC:2.4.1.4]
synonym: "sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.4]
xref: EC:2.4.1.4
xref: MetaCyc:AMYLOSUCRASE-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047670
name: anhydrotetracycline monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: anhydrotetracycline + NADPH + O2 = 12-dehydrotetracycline + NADP+ + H2O." [EC:1.14.13.38, MetaCyc:ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN]
synonym: "anhydrotetracycline oxygenase activity" EXACT [EC:1.14.13.38]
synonym: "anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.38]
synonym: "ATC oxygenase activity" EXACT [EC:1.14.13.38]
xref: EC:1.14.13.38
xref: MetaCyc:ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047671
name: anthranilate adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + anthranilate = diphosphate + N-adenylylanthranilate." [EC:2.7.7.55, MetaCyc:ANTHRANILATE-ADENYLYLTRANSFERASE-RXN]
synonym: "anthranilic acid adenylyltransferase activity" EXACT [EC:2.7.7.55]
synonym: "ATP:anthranilate adenylyltransferase activity" EXACT []
synonym: "ATP:anthranilate N-adenylyltransferase activity" EXACT [EC:2.7.7.55]
xref: EC:2.7.7.55
xref: MetaCyc:ANTHRANILATE-ADENYLYLTRANSFERASE-RXN
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0047672
name: anthranilate N-benzoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoyl-CoA + anthranilate = CoA + N-benzoylanthranilate." [EC:2.3.1.144, MetaCyc:ANTHRANILATE-N-BENZOYLTRANSFERASE-RXN]
synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.3.1.144]
xref: EC:2.3.1.144
xref: MetaCyc:ANTHRANILATE-N-BENZOYLTRANSFERASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047673
name: anthranilate N-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonyl-CoA + anthranilate = CoA + N-malonylanthranilate." [EC:2.3.1.113, MetaCyc:ANTHRANILATE-N-MALONYLTRANSFERASE-RXN]
synonym: "malonyl-CoA:anthranilate N-malonyltransferase activity" EXACT [EC:2.3.1.113]
xref: EC:2.3.1.113
xref: MetaCyc:ANTHRANILATE-N-MALONYLTRANSFERASE-RXN
is_a: GO:0050735 ! N-malonyltransferase activity

[Term]
id: GO:0047674
name: apiose 1-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-apiitol + NAD+ = D-apiose + NADH." [EC:1.1.1.114, MetaCyc:APIOSE-1-REDUCTASE-RXN]
synonym: "D-apiitol reductase activity" EXACT [EC:1.1.1.114]
synonym: "D-apiitol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.114]
synonym: "D-apiose reductase activity" EXACT [EC:1.1.1.114]
xref: EC:1.1.1.114
xref: MetaCyc:APIOSE-1-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047675
name: arabinonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H2O." [EC:4.2.1.5, MetaCyc:ARABINONATE-DEHYDRATASE-RXN]
synonym: "D-arabinonate hydro-lyase (2-dehydro-3-deoxy-D-arabinonate-forming)" EXACT [EC:4.2.1.5]
synonym: "D-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.5]
xref: EC:4.2.1.5
xref: MetaCyc:ARABINONATE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047676
name: arachidonate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA." [EC:6.2.1.15, MetaCyc:ARACHIDONATE--COA-LIGASE-RXN]
synonym: "arachidonate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.15]
synonym: "arachidonoyl-CoA synthetase activity" EXACT [EC:6.2.1.15]
xref: EC:6.2.1.15
xref: MetaCyc:ARACHIDONATE--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047677
name: arachidonate 8-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + O2 = (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate." [EC:1.13.11.40, MetaCyc:ARACHIDONATE-8-LIPOXYGENASE-RXN]
synonym: "8(R)-lipoxygenase activity" EXACT [EC:1.13.11.40]
synonym: "8-lipoxygenase activity" NARROW [EC:1.13.11.40]
synonym: "arachidonate:oxygen 8-oxidoreductase activity" EXACT [EC:1.13.11.40]
xref: EC:1.13.11.40
xref: MetaCyc:ARACHIDONATE-8-LIPOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047678
name: arginine 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine + O2 = 4-guanidinobutanamide + CO2 + H2O." [EC:1.13.12.1, MetaCyc:ARGININE-2-MONOOXYGENASE-RXN]
synonym: "arginine decarboxy-oxidase activity" EXACT [EC:1.13.12.1]
synonym: "arginine monooxygenase activity" EXACT [EC:1.13.12.1]
synonym: "arginine oxygenase (decarboxylating) activity" EXACT [EC:1.13.12.1]
synonym: "L-arginine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.1]
xref: EC:1.13.12.1
xref: MetaCyc:ARGININE-2-MONOOXYGENASE-RXN
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0047679
name: arginine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arginine = D-arginine." [EC:5.1.1.9, MetaCyc:ARGININE-RACEMASE-RXN]
xref: EC:5.1.1.9
xref: MetaCyc:ARGININE-RACEMASE-RXN
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0047680
name: aryl-acylamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an anilide + H2O = a carboxylate + aniline." [EC:3.5.1.13, MetaCyc:ARYL-ACYLAMIDASE-RXN]
subset: gosubset_prok
synonym: "AAA-1" RELATED [EC:3.5.1.13]
synonym: "AAA-2" RELATED [EC:3.5.1.13]
synonym: "aryl-acylamide amidohydrolase activity" EXACT [EC:3.5.1.13]
synonym: "brain acetylcholinesterase (is associated with AAA-2)" EXACT [EC:3.5.1.13]
synonym: "pseudocholinesterase (associated with arylacylamidase)" EXACT [EC:3.5.1.13]
xref: EC:3.5.1.13
xref: MetaCyc:ARYL-ACYLAMIDASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047681
name: aryl-alcohol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH." [EC:1.1.1.91, MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN]
synonym: "aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.91]
synonym: "aryl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.91]
synonym: "coniferyl alcohol dehydrogenase" BROAD [EC:1.1.1.91]
synonym: "NADPH-linked benzaldehyde reductase activity" EXACT [EC:1.1.1.91]
xref: EC:1.1.1.91
xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047682
name: aryl-alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2." [EC:1.1.3.7, MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN]
synonym: "arom. alcohol oxidase activity" EXACT [EC:1.1.3.7]
synonym: "aryl alcohol oxidase activity" EXACT [EC:1.1.3.7]
synonym: "aryl-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.7]
synonym: "veratryl alcohol oxidase activity" NARROW [EC:1.1.3.7]
xref: EC:1.1.3.7
xref: MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047683
name: aryl-aldehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP." [EC:1.2.1.30, MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-NADP+-RXN]
synonym: "aromatic acid reductase activity" EXACT [EC:1.2.1.30]
synonym: "aryl-aldehyde:NADP+ oxidoreductase (ATP-forming)" EXACT [EC:1.2.1.30]
xref: EC:1.2.1.30
xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047684
name: arylamine glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine." [EC:2.4.1.71, MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN]
synonym: "UDP glucose-arylamine glucosyltransferase activity" EXACT [EC:2.4.1.71]
synonym: "UDP-glucose:arylamine N-D-glucosyltransferase activity" EXACT [EC:2.4.1.71]
synonym: "UDPglucose:arylamine N-D-glucosyltransferase activity" EXACT [EC:2.4.1.71]
synonym: "uridine diphosphoglucose-arylamine glucosyltransferase activity" EXACT [EC:2.4.1.71]
xref: EC:2.4.1.71
xref: MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047685
name: amine sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate." [EC:2.8.2.3, MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN]
synonym: "3'-phosphoadenylyl-sulfate:amine N-sulfotransferase activity" EXACT [EC:2.8.2.3]
synonym: "amine N-sulfotransferase activity" EXACT [EC:2.8.2.3]
synonym: "amine sulphotransferase activity" EXACT []
synonym: "arylamine sulfotransferase activity" EXACT []
xref: EC:2.8.2.3
xref: MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047686
name: arylsulfate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aryl sulfate + a phenol = a phenol + an aryl sulfate." [EC:2.8.2.22, MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN]
subset: gosubset_prok
synonym: "arylsulfate-phenol sulfotransferase activity" EXACT [EC:2.8.2.22]
synonym: "arylsulfate:phenol sulfotransferase activity" EXACT [EC:2.8.2.22]
synonym: "arylsulfotransferase" BROAD [EC:2.8.2.22]
synonym: "arylsulphate sulphotransferase activity" EXACT []
synonym: "ASST" RELATED [EC:2.8.2.22]
xref: EC:2.8.2.22
xref: MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047687
name: ascorbate 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + O2 + ascorbate = L-threonate + oxalate." [EC:1.13.11.13, MetaCyc:ASCORBATE-23-DIOXYGENASE-RXN]
synonym: "AAoxygenase activity" EXACT [EC:1.13.11.13]
synonym: "ascorbate:oxygen 2,3-oxidoreductase (bond-cleaving)" EXACT [EC:1.13.11.13]
xref: EC:1.13.11.13
xref: MetaCyc:ASCORBATE-23-DIOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047688
name: aspartate 4-decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate = L-alanine + CO2." [EC:4.1.1.12, MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN]
subset: gosubset_prok
synonym: "aminomalonic decarboxylase activity" EXACT [EC:4.1.1.12]
synonym: "aspartate beta-decarboxylase activity" EXACT [EC:4.1.1.12]
synonym: "aspartate omega-decarboxylase activity" EXACT [EC:4.1.1.12]
synonym: "aspartic beta-decarboxylase activity" EXACT [EC:4.1.1.12]
synonym: "aspartic omega-decarboxylase activity" EXACT [EC:4.1.1.12]
synonym: "cysteine sulfinic desulfinase activity" EXACT [EC:4.1.1.12]
synonym: "desulfinase activity" EXACT [EC:4.1.1.12]
synonym: "L-aspartate 4-carboxy-lyase (L-alanine-forming)" EXACT [EC:4.1.1.12]
synonym: "L-aspartate 4-carboxy-lyase activity" EXACT [EC:4.1.1.12]
synonym: "L-aspartate beta-decarboxylase activity" EXACT [EC:4.1.1.12]
synonym: "L-cysteine sulfinate acid desulfinase activity" EXACT [EC:4.1.1.12]
xref: EC:4.1.1.12
xref: MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047689
name: aspartate racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-aspartate = D-aspartate." [EC:5.1.1.13, MetaCyc:ASPARTATE-RACEMASE-RXN]
subset: gosubset_prok
synonym: "D-aspartate racemase activity" EXACT [EC:5.1.1.13]
xref: EC:5.1.1.13
xref: MetaCyc:ASPARTATE-RACEMASE-RXN
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0047690
name: aspartyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-asparagine + hydroxylamine = NH3 + L-aspartylhydroxamate." [EC:2.3.2.7, MetaCyc:ASPARTYLTRANSFERASE-RXN]
synonym: "aspartotransferase activity" EXACT [EC:2.3.2.7]
synonym: "beta-aspartyl transferase activity" EXACT [EC:2.3.2.7]
synonym: "L-asparagine:hydroxylamine gamma-aspartyltransferase activity" EXACT [EC:2.3.2.7]
xref: EC:2.3.2.7
xref: MetaCyc:ASPARTYLTRANSFERASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0047691
name: aspulvinone dimethylallyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 dimethylallyl diphosphate + aspulvinone E = 2 diphosphate + aspulvinone H." [EC:2.5.1.35, MetaCyc:ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN]
synonym: "dimethylallyl pyrophosphate:aspulvinone dimethylallyltransferase activity" EXACT [EC:2.5.1.35]
synonym: "dimethylallyl-diphosphate:aspulvinone-E dimethylallyltransferase activity" EXACT [EC:2.5.1.35]
xref: EC:2.5.1.35
xref: MetaCyc:ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047692
name: ATP deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ITP + NH3." [EC:3.5.4.18, MetaCyc:ATP-DEAMINASE-RXN]
synonym: "adenosine triphosphate deaminase activity" EXACT [EC:3.5.4.18]
synonym: "ATP aminohydrolase activity" EXACT [EC:3.5.4.18]
xref: EC:3.5.4.18
xref: MetaCyc:ATP-DEAMINASE-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047693
name: ATP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = AMP + diphosphate." [EC:3.6.1.8, MetaCyc:ATP-PYROPHOSPHATASE-RXN]
subset: gosubset_prok
synonym: "adenosine triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.8]
synonym: "ATP diphosphohydrolase" BROAD [EC:3.6.1.8]
synonym: "ATP diphosphohydrolase (diphosphate-forming)" EXACT [EC:3.6.1.8]
synonym: "ATP pyrophosphatase activity" EXACT []
xref: EC:3.6.1.8
xref: MetaCyc:ATP-PYROPHOSPHATASE-RXN
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity

[Term]
id: GO:0047694
name: barbiturase activity
namespace: molecular_function
def: "Catalysis of the reaction: barbiturate + H2O = malonate + urea." [EC:3.5.2.1, MetaCyc:BARBITURASE-RXN]
synonym: "barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming)" EXACT [EC:3.5.2.1]
xref: EC:3.5.2.1
xref: MetaCyc:BARBITURASE-RXN
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0047695
name: benzoin aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoin = 2 benzaldehyde." [EC:4.1.2.38, MetaCyc:BENZOIN-ALDOLASE-RXN]
subset: gosubset_prok
synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2- activity" EXACT [EC:4.1.2.38]
synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase (benzaldehyde-forming)" EXACT [EC:4.1.2.38]
synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase activity" EXACT [EC:4.1.2.38]
synonym: "benzaldehyde lyase activity" EXACT [EC:4.1.2.38]
synonym: "diphenylethanone benzaldehyde-lyase activity" EXACT [EC:4.1.2.38]
xref: EC:4.1.2.38
xref: MetaCyc:BENZOIN-ALDOLASE-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047696
name: beta-adrenergic receptor kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor." [EC:2.7.11.15, MetaCyc:BETA-ADRENERGIC-RECEPTOR-KINASE-RXN]
synonym: "[b-adrenergic-receptor] kinase activity" EXACT [EC:2.7.11.15]
synonym: "ADRBK1" RELATED [EC:2.7.11.15]
synonym: "adrenergic receptor kinase activity" BROAD [EC:2.7.11.15]
synonym: "ATP:beta-adrenergic-receptor phosphotransferase activity" BROAD [EC:2.7.11.15]
synonym: "BARK1" RELATED [EC:2.7.11.15]
synonym: "beta-adrenergic receptor-specific kinase activity" EXACT [EC:2.7.11.15]
synonym: "beta-adrenergic-receptor kinase (phosphorylating) activity" EXACT [EC:2.7.11.15]
synonym: "beta-adrenergic-receptor kinase activity" EXACT [EC:2.7.11.15]
synonym: "beta-adrenoceptor kinase 1 activity" NARROW [EC:2.7.11.15]
synonym: "beta-adrenoceptor kinase 2 activity" NARROW [EC:2.7.11.15]
synonym: "beta-adrenoceptor kinase activity" EXACT [EC:2.7.11.15]
synonym: "beta-AR kinase activity" EXACT [EC:2.7.11.15]
synonym: "beta-ARK" RELATED [EC:2.7.11.15]
synonym: "beta-ARK 1" RELATED [EC:2.7.11.15]
synonym: "beta-ARK 2" RELATED [EC:2.7.11.15]
synonym: "beta-receptor kinase activity" EXACT [EC:2.7.11.15]
synonym: "beta2ARK" RELATED [EC:2.7.11.15]
synonym: "betaARK1" RELATED [EC:2.7.11.15]
synonym: "GRK2" RELATED [EC:2.7.11.15]
synonym: "GRK3" RELATED [EC:2.7.11.15]
synonym: "STK15" RELATED [EC:2.7.11.15]
xref: EC:2.7.11.15
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0047697
name: beta-alanopine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-alanopine + NAD+ + H2O = beta-alanine + pyruvate + NADH." [EC:1.5.1.26, MetaCyc:BETA-ALANOPINE-DEHYDROGENASE-RXN]
synonym: "b-alanopine dehydrogenase activity" EXACT []
synonym: "N-(D-1-carboxyethyl)-beta-alanine:NAD+ oxidoreductase (beta-alanine-forming)" EXACT [EC:1.5.1.26]
xref: EC:1.5.1.26
xref: MetaCyc:BETA-ALANOPINE-DEHYDROGENASE-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047698
name: beta-alanyl-CoA ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3." [EC:4.3.1.6, MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN]
synonym: "b-alanyl-CoA ammonia-lyase activity" EXACT []
synonym: "beta-alanyl coenzyme A ammonia-lyase activity" EXACT [EC:4.3.1.6]
synonym: "beta-alanyl-CoA ammonia-lyase (acryloyl-CoA-forming)" EXACT [EC:4.3.1.6]
xref: EC:4.3.1.6
xref: MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0047699
name: beta-diketone hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: nonane-4,6-dione + H2O = pentan-2-one + butanoate." [EC:3.7.1.7, MetaCyc:BETA-DIKETONE-HYDROLASE-RXN]
synonym: "b-diketone hydrolase activity" EXACT []
synonym: "nonane-4,6-dione acylhydrolase activity" EXACT [EC:3.7.1.7]
synonym: "oxidized PVA hydrolase activity" EXACT [EC:3.7.1.7]
xref: EC:3.7.1.7
xref: MetaCyc:BETA-DIKETONE-HYDROLASE-RXN
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0047700
name: beta-glucoside kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + cellobiose = ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose." [EC:2.7.1.85, MetaCyc:BETA-GLUCOSIDE-KINASE-RXN]
subset: gosubset_prok
synonym: "ATP:cellobiose 6-phosphotransferase activity" EXACT [EC:2.7.1.85]
synonym: "b-glucoside kinase activity" EXACT []
synonym: "beta-D-glucoside kinase (phosphorylating)" EXACT [EC:2.7.1.85]
xref: EC:2.7.1.85
xref: MetaCyc:BETA-GLUCOSIDE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047701
name: beta-L-arabinosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol." [EC:3.2.1.88, MetaCyc:BETA-L-ARABINOSIDASE-RXN]
synonym: "b-L-arabinosidase activity" EXACT []
synonym: "beta-L-arabinoside arabinohydrolase activity" EXACT [EC:3.2.1.88]
synonym: "vicianosidase activity" EXACT [EC:3.2.1.88]
xref: EC:3.2.1.88
xref: MetaCyc:BETA-L-ARABINOSIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047702
name: beta-lysine 5,6-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate." [EC:5.4.3.3, MetaCyc:BETA-LYSINE-56-AMINOMUTASE-RXN]
subset: gosubset_prok
synonym: "(3S)-3,6-diaminohexanoate 5,6-aminomutase activity" EXACT [EC:5.4.3.3]
synonym: "b-lysine 5,6-aminomutase activity" EXACT []
synonym: "beta-lysine mutase activity" EXACT [EC:5.4.3.3]
synonym: "L-beta-lysine 5,6-aminomutase activity" EXACT [EC:5.4.3.3]
xref: EC:5.4.3.3
xref: MetaCyc:BETA-LYSINE-56-AMINOMUTASE-RXN
is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups

[Term]
id: GO:0047703
name: beta-nitroacrylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-nitropropanoate + NADP+ = 3-nitroacrylate + NADPH." [EC:1.3.1.16, MetaCyc:BETA-NITROACRYLATE-REDUCTASE-RXN]
synonym: "3-nitropropanoate:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.16]
synonym: "b-nitroacrylate reductase activity" EXACT []
xref: EC:1.3.1.16
xref: MetaCyc:BETA-NITROACRYLATE-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047704
name: bile-salt sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate." [EC:2.8.2.14, MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN]
synonym: "3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity" EXACT [EC:2.8.2.14]
synonym: "BAST I activity" NARROW [EC:2.8.2.14]
synonym: "bile acid sulfotransferase I activity" NARROW [EC:2.8.2.14]
synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" EXACT [EC:2.8.2.14]
synonym: "bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase activity" EXACT [EC:2.8.2.14]
synonym: "bile-salt sulphotransferase activity" EXACT []
synonym: "glycolithocholate sulfotransferase activity" NARROW [EC:2.8.2.14]
xref: EC:2.8.2.14
xref: MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047705
name: bilirubin oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 bilirubin + O2 = 2 biliverdin + 2 H2O." [EC:1.3.3.5, MetaCyc:BILIRUBIN-OXIDASE-RXN]
synonym: "bilirubin oxidase M-1" RELATED [EC:1.3.3.5]
synonym: "bilirubin:oxygen oxidoreductase activity" EXACT [EC:1.3.3.5]
xref: EC:1.3.3.5
xref: MetaCyc:BILIRUBIN-OXIDASE-RXN
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0047706
name: biochanin-A reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrobiochanin A + NADP+ = biochanin A + NADPH." [EC:1.3.1.46, MetaCyc:BIOCHANIN-A-REDUCTASE-RXN]
synonym: "dihydrobiochanin-A:NADP+ delta2-oxidoreductase activity" EXACT [EC:1.3.1.46]
xref: EC:1.3.1.46
xref: MetaCyc:BIOCHANIN-A-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047707
name: biotin-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA." [EC:6.2.1.11, MetaCyc:BIOTIN--COA-LIGASE-RXN]
synonym: "biotin CoA synthetase activity" EXACT [EC:6.2.1.11]
synonym: "biotin:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.11]
synonym: "biotinyl coenzyme A synthetase activity" EXACT [EC:6.2.1.11]
synonym: "biotinyl-CoA synthetase activity" EXACT [EC:6.2.1.11]
xref: EC:6.2.1.11
xref: MetaCyc:BIOTIN--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047708
name: biotinidase activity
namespace: molecular_function
def: "Catalysis of the reaction: biotin amide + H2O = biotin + NH3." [EC:3.5.1.12, MetaCyc:BIOTINIDASE-RXN]
synonym: "amidohydrolase biotinidase activity" EXACT [EC:3.5.1.12]
synonym: "biotin-amide amidohydrolase activity" EXACT [EC:3.5.1.12]
xref: EC:3.5.1.12
xref: MetaCyc:BIOTINIDASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047709
name: bis(2-ethylhexyl)phthalate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H2O = 2-ethylhexyl phthalate + 2-ethylhexan-1-ol." [EC:3.1.1.60, MetaCyc:BIS2-ETHYLHEXYLPHTHALATE-ESTERASE-RXN]
synonym: "bis(2-ethylhexyl)phthalate acylhydrolase activity" EXACT [EC:3.1.1.60]
synonym: "DEHP esterase activity" EXACT [EC:3.1.1.60]
xref: EC:3.1.1.60
xref: MetaCyc:BIS2-ETHYLHEXYLPHTHALATE-ESTERASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047710
name: bis(5'-adenosyl)-triphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: P1-P3-bis(5'-adenosyl) triphosphate + H2O = ADP + AMP." [EC:3.6.1.29, MetaCyc:BIS5-ADENOSYL-TRIPHOSPHATASE-RXN]
synonym: "1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase activity" EXACT [EC:3.6.1.29]
synonym: "AP(3)A hydrolase activity" EXACT [EC:3.6.1.29]
synonym: "AP(3)Aase activity" EXACT [EC:3.6.1.29]
synonym: "AP3A hydrolase activity" EXACT [EC:3.6.1.29]
synonym: "AP3Aase activity" EXACT [EC:3.6.1.29]
synonym: "diadenosine 5',5'''-P(1),P(3)-triphosphate hydrolase activity" EXACT [EC:3.6.1.29]
synonym: "diadenosine 5',5'''-P1,P3-triphosphate hydrolase activity" EXACT [EC:3.6.1.29]
synonym: "diadenosine 5,5-P1,P3-triphosphatase activity" EXACT [EC:3.6.1.29]
synonym: "dinucleosidetriphosphatase activity" EXACT [EC:3.6.1.29]
synonym: "P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase activity" EXACT [EC:3.6.1.29]
xref: EC:3.6.1.29
xref: MetaCyc:BIS5-ADENOSYL-TRIPHOSPHATASE-RXN
is_a: GO:0004551 ! nucleotide diphosphatase activity

[Term]
id: GO:0047711
name: blasticidin-S deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3." [EC:3.5.4.23, MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN]
subset: gosubset_prok
synonym: "blasticidin-S aminohydrolase activity" EXACT [EC:3.5.4.23]
xref: EC:3.5.4.23
xref: MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047712
name: Cypridina-luciferin 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light." [EC:1.13.12.6, MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN]
synonym: "Cypridina luciferase activity" EXACT [EC:1.13.12.6]
synonym: "Cypridina-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.6]
synonym: "Cypridina-type luciferase activity" EXACT [EC:1.13.12.6]
synonym: "cypridina-type luciferase activity" EXACT [EC:1.13.12.6]
synonym: "luciferase (Cypridina luciferin)" EXACT [EC:1.13.12.6]
synonym: "luciferase activity" BROAD [EC:1.13.12.6]
xref: EC:1.13.12.6
xref: MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0047713
name: galactitol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactitol + NAD+ = D-tagatose + NADH." [EC:1.1.1.16, MetaCyc:GALACTITOL-2-DEHYDROGENASE-RXN]
xref: EC:1.1.1.16
xref: MetaCyc:GALACTITOL-2-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
is_a: GO:0031320 ! hexitol dehydrogenase activity

[Term]
id: GO:0047714
name: galactolipase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates." [EC:3.1.1.26, MetaCyc:GALACTOLIPASE-RXN]
synonym: "1,2-diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase activity" EXACT [EC:3.1.1.26]
synonym: "galactolipid acylhydrolase activity" EXACT [EC:3.1.1.26]
synonym: "galactolipid lipase activity" EXACT [EC:3.1.1.26]
synonym: "polygalactolipase activity" EXACT [EC:3.1.1.26]
xref: EC:3.1.1.26
xref: MetaCyc:GALACTOLIPASE-RXN
is_a: GO:0004091 ! carboxylesterase activity
is_a: GO:0016298 ! lipase activity

[Term]
id: GO:0047715
name: hypotaurocyamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: hypotaurocyamine + ATP = N(omega)-phosphohypotaurocyamine + ADP." [EC:2.7.3.6, MetaCyc:HYPOTAUROCYAMINE-KINASE-RXN]
synonym: "ATP:hypotaurocyamine N-phosphotransferase activity" EXACT [EC:2.7.3.6]
xref: EC:2.7.3.6
xref: MetaCyc:HYPOTAUROCYAMINE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0047716
name: imidazole N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + imidazole = CoA + N-acetylimidazole." [EC:2.3.1.2, MetaCyc:IMIDAZOLE-N-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA:imidazole N-acetyltransferase activity" EXACT [EC:2.3.1.2]
synonym: "imidazole acetylase activity" EXACT [EC:2.3.1.2]
synonym: "imidazole acetyltransferase activity" EXACT [EC:2.3.1.2]
xref: EC:2.3.1.2
xref: MetaCyc:IMIDAZOLE-N-ACETYLTRANSFERASE-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047717
name: imidazoleacetate 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-imidazoleacetate + NADH + O2 = 5-hydroxy-4-imidazoleacetate + NAD+ + H2O." [EC:1.14.13.5, MetaCyc:IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN]
synonym: "4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.13.5]
synonym: "imidazoleacetate hydroxylase activity" EXACT [EC:1.14.13.5]
synonym: "imidazoleacetic hydroxylase activity" EXACT []
synonym: "imidazoleacetic monooxygenase activity" EXACT [EC:1.14.13.5]
xref: EC:1.14.13.5
xref: MetaCyc:IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047718
name: indanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+." [EC:1.1.1.112, MetaCyc:INDANOL-DEHYDROGENASE-RXN]
synonym: "indan-1-ol:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.112]
xref: EC:1.1.1.112
xref: MetaCyc:INDANOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047719
name: indole 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole + O2 = 2-formylaminobenzaldehyde." [EC:1.13.11.17, MetaCyc:INDOLE-23-DIOXYGENASE-RXN]
synonym: "IDO" RELATED [EC:1.13.11.17]
synonym: "indole oxidase activity" EXACT [EC:1.13.11.17]
synonym: "indole-oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.17]
synonym: "indole:O2 oxidoreductase activity" EXACT [EC:1.13.11.17]
synonym: "indole:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.17]
xref: EC:1.13.11.17
xref: MetaCyc:INDOLE-23-DIOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047720
name: indoleacetaldoxime dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetaldoxime = indole-3-acetonitrile + H2O." [EC:4.2.1.29, MetaCyc:INDOLEACETALDOXIME-DEHYDRATASE-RXN]
synonym: "(indol-3-yl)acetaldehyde-oxime hydro-lyase [(indol-3-yl)acetonitrile-forming]" RELATED [EC:4.99.1.6]
synonym: "(indol-3-yl)acetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.6]
synonym: "3-indoleacetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6]
synonym: "indole-3-acetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.6]
synonym: "indole-3-acetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6]
synonym: "indoleacetaldoxime hydro-lyase activity" EXACT [EC:4.99.1.6]
xref: EC:4.99.1.6
xref: MetaCyc:RXN-1403
is_a: GO:0016829 ! lyase activity

[Term]
id: GO:0047721
name: indoleacetate-lysine synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + indoleacetate + L-lysine = ADP + phosphate + N6-[(indole-3-yl)acetyl]-L-lysine." [EC:6.3.2.20, MetaCyc:INDOLEACETATE--LYSINE-LIGASE-RXN]
subset: gosubset_prok
synonym: "(indol-3-yl)acetate:L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.20]
synonym: "IAA-lysine synthetase activity" EXACT [EC:6.3.2.20]
synonym: "indoleacetate-lysine ligase activity" EXACT []
synonym: "indoleacetate:L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.20]
synonym: "N-(indole-3-acetyl)-L-lysine synthetase activity" EXACT [EC:6.3.2.20]
xref: EC:6.3.2.20
xref: MetaCyc:INDOLEACETATE--LYSINE-LIGASE-RXN
is_a: GO:0010279 ! indole-3-acetic acid amido synthetase activity

[Term]
id: GO:0047722
name: indolelactate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: indolelactate + NAD+ = indolepyruvate + NADH." [EC:1.1.1.110, MetaCyc:INDOLELACTATE-DEHYDROGENASE-RXN]
synonym: "(indol-3-yl)lactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.110]
synonym: "indole-3-lactate dehydrogenase activity" EXACT []
synonym: "indolelactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.110]
xref: EC:1.1.1.110
xref: MetaCyc:INDOLELACTATE-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047723
name: inosinate nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-inosinate + H2O = D-ribose 5-phosphate + hypoxanthine." [EC:3.2.2.12, MetaCyc:INOSINATE-NUCLEOSIDASE-RXN]
synonym: "5'-inosinate phosphoribohydrolase activity" EXACT [EC:3.2.2.12]
xref: EC:3.2.2.12
xref: MetaCyc:INOSINATE-NUCLEOSIDASE-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047724
name: inosine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine." [EC:3.2.2.2, MetaCyc:INOSINE-NUCLEOSIDASE-RXN]
synonym: "inosinase activity" EXACT [EC:3.2.2.2]
synonym: "inosine ribohydrolase activity" EXACT [EC:3.2.2.2]
synonym: "inosine-guanosine nucleosidase activity" EXACT [EC:3.2.2.2]
xref: EC:3.2.2.2
xref: MetaCyc:INOSINE-NUCLEOSIDASE-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0047725
name: inulosucrase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + 2,1-beta-D-fructosyl(n) = glucose + 2,1-beta-D-fructosyl(n+1)." [EC:2.4.1.9, MetaCyc:INULOSUCRASE-RXN]
subset: gosubset_prok
synonym: "sucrose 1-fructosyl transferase activity" EXACT [EC:2.4.1.9]
synonym: "sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.9]
synonym: "sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.9]
xref: EC:2.4.1.9
xref: MetaCyc:INULOSUCRASE-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047726
name: iron-cytochrome-c reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+." [EC:1.9.99.1, MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN]
synonym: "ferrocytochrome-c:Fe3+ oxidoreductase activity" EXACT [EC:1.9.99.1]
synonym: "iron-cytochrome c reductase activity" EXACT [EC:1.9.99.1]
xref: EC:1.9.99.1
xref: MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN
is_a: GO:0016675 ! oxidoreductase activity, acting on heme group of donors

[Term]
id: GO:0047727
name: isobutyryl-CoA mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methylpropanoyl-CoA = butanoyl-CoA." [EC:5.4.99.13, MetaCyc:ISOBUTYRYL-COA-MUTASE-RXN]
subset: gosubset_prok
synonym: "2-methylpropanoyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.13]
synonym: "butyryl-CoA:isobutyryl-CoA mutase activity" EXACT [EC:5.4.99.13]
synonym: "isobutyryl coenzyme A mutase activity" EXACT [EC:5.4.99.13]
xref: EC:5.4.99.13
xref: MetaCyc:ISOBUTYRYL-COA-MUTASE-RXN
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0047728
name: carnitine 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + L-carnitine = NADH + 3-dehydrocarnitine." [EC:1.1.1.108, MetaCyc:CARNITINE-3-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "carnitine:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.108]
xref: EC:1.1.1.108
xref: MetaCyc:CARNITINE-3-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047729
name: carnitine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: carnitine = 2-methylcholine + CO2." [EC:4.1.1.42, MetaCyc:CARNITINE-DECARBOXYLASE-RXN]
synonym: "carnitine carboxy-lyase (2-methylcholine-forming)" EXACT [EC:4.1.1.42]
synonym: "carnitine carboxy-lyase activity" EXACT [EC:4.1.1.42]
xref: EC:4.1.1.42
xref: MetaCyc:CARNITINE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047730
name: carnosine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine." [EC:6.3.2.11, MetaCyc:CARNOSINE-SYNTHASE-RXN]
synonym: "carnosine synthetase activity" EXACT [EC:6.3.2.11]
synonym: "carnosine-anserine synthetase activity" EXACT [EC:6.3.2.11]
synonym: "carnosine-homocarnosine synthetase activity" EXACT [EC:6.3.2.11]
synonym: "homocarnosine-carnosine synthetase activity" EXACT [EC:6.3.2.11]
synonym: "L-histidine:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.11]
xref: EC:6.3.2.11
xref: MetaCyc:CARNOSINE-SYNTHASE-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047731
name: catechol oxidase (dimerizing) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O." [EC:1.1.3.14, MetaCyc:CATECHOL-OXIDASE-DIMERIZING-RXN]
synonym: "catechol:oxygen oxidoreductase (dimerizing)" EXACT [EC:1.1.3.14]
xref: EC:1.1.3.14
xref: MetaCyc:CATECHOL-OXIDASE-DIMERIZING-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047732
name: CDP-abequose epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose." [EC:5.1.3.10, MetaCyc:CDP-ABEQUOSE-EPIMERASE-RXN]
synonym: "CDP-3,6-dideoxy-D-glucose 2-epimerase activity" EXACT [EC:5.1.3.10]
synonym: "CDP-D-abequose 2-epimerase activity" EXACT [EC:5.1.3.10]
synonym: "CDP-paratose 2-epimerase activity" EXACT [EC:5.1.3.10]
synonym: "CDP-paratose epimerase activity" EXACT [EC:5.1.3.10]
synonym: "CDP-tyvelose 2-epimerase activity" EXACT [EC:5.1.3.10]
synonym: "cytidine diphosphate paratose-2-epimerase activity" EXACT [EC:5.1.3.10]
synonym: "cytidine diphosphoabequose epimerase activity" EXACT [EC:5.1.3.10]
synonym: "cytidine diphosphodideoxyglucose epimerase activity" EXACT [EC:5.1.3.10]
synonym: "cytidine diphosphoparatose epimerase activity" EXACT [EC:5.1.3.10]
xref: EC:5.1.3.10
xref: MetaCyc:RXN-9160
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047733
name: CDP-glucose 4,6-dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O." [EC:4.2.1.45, MetaCyc:CDP-GLUCOSE-46-DEHYDRATASE-RXN]
subset: gosubset_prok
synonym: "CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.45]
synonym: "CDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.45]
synonym: "CDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.45]
synonym: "CDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.45]
synonym: "cytidine diphosphoglucose oxidoreductase activity" EXACT [EC:4.2.1.45]
xref: EC:4.2.1.45
xref: MetaCyc:CDP-GLUCOSE-46-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047734
name: CDP-glycerol diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-glycerol + H2O = CMP + sn-glycerol 3-phosphate." [EC:3.6.1.16, MetaCyc:CDP-GLYCEROL-PYROPHOSPHATASE-RXN]
synonym: "CDP-glycerol phosphoglycerohydrolase activity" EXACT [EC:3.6.1.16]
synonym: "CDP-glycerol pyrophosphatase activity" EXACT []
synonym: "CDPglycerol diphosphatase activity" EXACT [EC:3.6.1.16]
synonym: "CDPglycerol phosphoglycerohydrolase activity" EXACT [EC:3.6.1.16]
synonym: "CDPglycerol pyrophosphatase activity" EXACT [EC:3.6.1.16]
synonym: "cytidine diphosphoglycerol pyrophosphatase activity" EXACT [EC:3.6.1.16]
xref: EC:3.6.1.16
xref: MetaCyc:CDP-GLYCEROL-PYROPHOSPHATASE-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047735
name: cellobiose dehydrogenase (acceptor) activity
namespace: molecular_function
alt_id: GO:0047737
def: "Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor." [EC:1.1.99.18, MetaCyc:CELLOBIOSE-DEHYDROGENASE-ACCEPTOR-RXN]
synonym: "CBOR activity" RELATED [EC:1.1.99.18]
synonym: "CDH activity" RELATED [EC:1.1.99.18]
synonym: "cellobiose dehydrogenase (quinone) activity" NARROW [EC:1.1.99.18]
synonym: "cellobiose dehydrogenase activity" EXACT [EC:1.1.99.18]
synonym: "cellobiose oxidase activity" EXACT [EC:1.1.99.18]
synonym: "cellobiose oxidoreductase activity" EXACT [EC:1.1.99.18]
synonym: "cellobiose-quinone oxidoreductase activity" NARROW [EC:1.1.99.18]
synonym: "cellobiose:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.18]
synonym: "cellobiose:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.18]
synonym: "cellobiose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.99.18]
synonym: "phanerochaete chrysosporium cellobiose oxidoreductase activity" EXACT [EC:1.1.99.18]
xref: EC:1.1.99.18
xref: MetaCyc:CELLOBIOSE-DEHYDROGENASE-ACCEPTOR-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047736
name: cellobiose epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose." [EC:5.1.3.11, MetaCyc:CELLOBIOSE-EPIMERASE-RXN]
synonym: "cellobiose 2-epimerase activity" EXACT [EC:5.1.3.11]
xref: EC:5.1.3.11
xref: MetaCyc:CELLOBIOSE-EPIMERASE-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047738
name: cellobiose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose." [EC:2.4.1.20, MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN]
subset: gosubset_prok
synonym: "cellobiose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.20]
xref: EC:2.4.1.20
xref: MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0047739
name: cephalosporin-C deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: cephalosporin C + H2O = deacetylcephalosporin C + acetate." [EC:3.1.1.41, MetaCyc:CEPHALOSPORIN-C-DEACETYLASE-RXN]
subset: gosubset_prok
synonym: "cephalosporin acetylesterase activity" EXACT [EC:3.1.1.41]
synonym: "cephalosporin C acetyl-esterase activity" EXACT [EC:3.1.1.41]
synonym: "cephalosporin C acetyl-hydrolase activity" EXACT [EC:3.1.1.41]
synonym: "cephalosporin C acetylase activity" EXACT [EC:3.1.1.41]
synonym: "cephalosporin C acetylesterase activity" EXACT [EC:3.1.1.41]
synonym: "cephalosporin C deacetylase activity" EXACT [EC:3.1.1.41]
synonym: "cephalosporin-C acetylhydrolase activity" EXACT [EC:3.1.1.41]
xref: EC:3.1.1.41
xref: MetaCyc:CEPHALOSPORIN-C-DEACETYLASE-RXN
is_a: GO:0004091 ! carboxylesterase activity
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0047740
name: cephalosporin-C transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: cephalosporin C + pyruvate = 7-(5-carboxyl-5-oxopentanyl)-aminocephalosporinate + L-alanine." [EC:2.6.1.74, MetaCyc:CEPHALOSPORIN-C-TRANSAMINASE-RXN]
synonym: "cephalosporin C aminotransferase activity" EXACT [EC:2.6.1.74]
synonym: "cephalosporin-C:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.74]
synonym: "L-alanine:cephalosporin-C aminotransferase activity" EXACT [EC:2.6.1.74]
xref: EC:2.6.1.74
xref: MetaCyc:CEPHALOSPORIN-C-TRANSAMINASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047741
name: cetraxate benzylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: cetraxate benzyl ester + H2O = cetraxate + benzyl alcohol." [EC:3.1.1.70, MetaCyc:CETRAXATE-BENZYLESTERASE-RXN]
synonym: "cetraxate-benzyl-ester benzylhydrolase activity" EXACT [EC:3.1.1.70]
xref: EC:3.1.1.70
xref: MetaCyc:CETRAXATE-BENZYLESTERASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047742
name: chenodeoxycholoyltaurine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine." [EC:3.5.1.74, MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN]
synonym: "chenodeoxycholoyltaurine amidohydrolase activity" EXACT [EC:3.5.1.74]
xref: EC:3.5.1.74
xref: MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047743
name: chlordecone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlordecone alcohol + NADP+ = chlordecone + NADPH." [EC:1.1.1.225, MetaCyc:CHLORDECONE-REDUCTASE-RXN]
synonym: "CDR activity" RELATED [EC:1.1.1.225]
synonym: "chlordecone-alcohol:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.225]
xref: EC:1.1.1.225
xref: MetaCyc:CHLORDECONE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047744
name: chloridazon-catechol dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)-3(2H)-pyridazinone." [EC:1.13.11.36, MetaCyc:CHLORIDAZON-CATECHOL-DIOXYGENASE-RXN]
synonym: "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.36]
xref: EC:1.13.11.36
xref: MetaCyc:CHLORIDAZON-CATECHOL-DIOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047745
name: chlorogenate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlorogenate + H2O = caffeate + quinate." [EC:3.1.1.42, MetaCyc:CHLOROGENATE-HYDROLASE-RXN]
synonym: "chlorogenase activity" EXACT [EC:3.1.1.42]
synonym: "chlorogenic acid esterase activity" EXACT [EC:3.1.1.42]
xref: EC:3.1.1.42
xref: MetaCyc:CHLOROGENATE-HYDROLASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047746
name: chlorophyllase activity
namespace: molecular_function
def: "Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide." [EC:3.1.1.14, MetaCyc:CHLOROPHYLLASE-RXN]
synonym: "chlorophyll chlorophyllidohydrolase activity" EXACT [EC:3.1.1.14]
xref: EC:3.1.1.14
xref: MetaCyc:CHLOROPHYLLASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047747
name: cholate-CoA ligase activity
namespace: molecular_function
alt_id: GO:0047477
def: "Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA." [EC:6.2.1.7, MetaCyc:CHOLATE--COA-LIGASE-RXN]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity" EXACT [EC:6.2.1.29]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity" EXACT []
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity" EXACT [EC:6.2.1.29]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity" EXACT [EC:6.2.1.29]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity" EXACT [EC:6.2.1.29]
synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity" EXACT [EC:6.2.1.29]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.29]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity" EXACT [EC:6.2.1.29]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity" EXACT [EC:6.2.1.29]
synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29]
synonym: "BAL activity" RELATED [EC:6.2.1.29]
synonym: "bile acid CoA ligase activity" RELATED [EC:6.2.1.29]
synonym: "bile acid coenzyme A ligase activity" RELATED [EC:6.2.1.29]
synonym: "cholate thiokinase activity" EXACT [EC:6.2.1.29]
synonym: "cholate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.29]
synonym: "cholic acid:CoA ligase activity" EXACT [EC:6.2.1.29]
synonym: "cholic thiokinase activity" EXACT [EC:6.2.1.29]
synonym: "choloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.29]
synonym: "choloyl-CoA synthetase activity" EXACT [EC:6.2.1.29]
synonym: "cholyl-CoA synthetase activity" EXACT [EC:6.2.1.29]
synonym: "THCA-CoA ligase activity" RELATED [EC:6.2.1.29]
synonym: "trihydroxycoprostanoyl-CoA synthetase activity" RELATED [EC:6.2.1.29]
xref: EC:6.2.1.7
xref: MetaCyc:CHOLATE--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047748
name: cholestanetetraol 26-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH." [EC:1.1.1.161, MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN]
synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase activity" EXACT [EC:1.1.1.161]
synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase activity" EXACT [EC:1.1.1.161]
synonym: "cholestanetetrol 26-dehydrogenase activity" EXACT [EC:1.1.1.161]
synonym: "TEHC-NAD oxidoreductase activity" EXACT [EC:1.1.1.161]
xref: EC:1.1.1.161
xref: MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047749
name: cholestanetriol 26-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O." [EC:1.14.13.15, MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN]
synonym: "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase activity" EXACT [EC:1.14.13.15]
synonym: "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase activity" BROAD [EC:1.14.13.15]
synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase activity" EXACT [EC:1.14.13.15]
synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase activity" EXACT [EC:1.14.13.15]
synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating)" EXACT [EC:1.14.13.15]
synonym: "cholestanetriol 26-hydroxylase activity" EXACT []
synonym: "cholesterol 27-hydroxylase activity" RELATED [EC:1.14.13.15]
synonym: "CYP27A" RELATED [EC:1.14.13.15]
synonym: "CYP27A1" RELATED [EC:1.14.13.15]
synonym: "cytochrome P450 27A1' activity" NARROW [EC:1.14.13.15]
synonym: "sterol 26-hydroxylase activity" BROAD [EC:1.14.13.15]
synonym: "sterol 27-hydroxylase activity" RELATED [EC:1.14.13.15]
xref: EC:1.14.13.15
xref: MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047750
name: cholestenol delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol." [EC:5.3.3.5, MetaCyc:CHOLESTENOL-DELTA-ISOMERASE-RXN]
synonym: "cholestenol D-isomerase activity" EXACT []
synonym: "delta7-cholestenol delta7-delta8-isomerase activity" EXACT [EC:5.3.3.5]
xref: EC:5.3.3.5
xref: MetaCyc:RXN66-25
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0047751
name: cholestenone 5-alpha-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-alpha-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH." [EC:1.3.1.22, MetaCyc:CHOLESTENONE-5-ALPHA-REDUCTASE-RXN]
synonym: "3-oxo-5alpha-steroid:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.22]
synonym: "3-oxosteroid 5alpha-reductase activity" EXACT [EC:1.3.1.22]
synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.1.22]
synonym: "4-ene-3-oxosteroid 5alpha-reductase activity" EXACT [EC:1.3.1.22]
synonym: "4-ene-5alpha-reductase activity" EXACT [EC:1.3.1.22]
synonym: "5alpha-reductase" BROAD [EC:1.3.1.22]
synonym: "cholest-4-en-3-one 5alpha-reductase activity" EXACT [EC:1.3.1.22]
synonym: "cholestenone 5a-reductase activity" EXACT []
synonym: "cholestenone 5alpha-reductase activity" EXACT [EC:1.3.1.22]
synonym: "delta4-3-ketosteroid 5alpha-oxidoreductase activity" EXACT [EC:1.3.1.22]
synonym: "reduced nicotinamide adenine dinucleotide phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase activity" EXACT [EC:1.3.1.22]
synonym: "steroid 5alpha-hydrogenase activity" EXACT [EC:1.3.1.22]
synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.1.22]
synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.1.22]
synonym: "testosterone delta4-5alpha-reductase activity" EXACT [EC:1.3.1.22]
synonym: "testosterone delta4-hydrogenase activity" EXACT [EC:1.3.1.22]
xref: EC:1.3.1.22
xref: MetaCyc:CHOLESTENONE-5-ALPHA-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047753
name: choline-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: choline sulfate + H2O = choline + sulfate." [EC:3.1.6.6, MetaCyc:CHOLINE-SULFATASE-RXN]
subset: gosubset_prok
synonym: "choline-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.6]
synonym: "choline-sulphatase activity" EXACT []
xref: EC:3.1.6.6
xref: MetaCyc:CHOLINE-SULFATASE-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0047754
name: choline sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + choline = adenosine 3',5'-bisphosphate + choline sulfate." [EC:2.8.2.6, MetaCyc:CHOLINE-SULFOTRANSFERASE-RXN]
synonym: "3'-phosphoadenylyl-sulfate:choline sulfotransferase activity" EXACT [EC:2.8.2.6]
synonym: "choline sulphokinase activity" EXACT [EC:2.8.2.6]
synonym: "choline sulphotransferase activity" EXACT []
xref: EC:2.8.2.6
xref: MetaCyc:CHOLINE-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047755
name: isocitrate epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate = (1S,2S)-1-hydroxypropane-1,2,3-tricarboxylate." [EC:5.1.2.6, MetaCyc:ISOCITRATE-EPIMERASE-RXN]
synonym: "(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate 1-epimerase activity" EXACT [EC:5.1.2.6]
xref: EC:5.1.2.6
xref: MetaCyc:ISOCITRATE-EPIMERASE-RXN
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0047756
name: chondroitin 4-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate." [EC:2.8.2.5, MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN]
synonym: "3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase activity" EXACT [EC:2.8.2.5]
synonym: "chondroitin 4-sulphotransferase activity" EXACT []
xref: EC:2.8.2.5
xref: MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN
is_a: GO:0034481 ! chondroitin sulfotransferase activity

[Term]
id: GO:0047757
name: chondroitin-glucuronate 5-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate." [EC:5.1.3.19, MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN]
synonym: "chondroitin D-glucuronosyl 5-epimerase activity" EXACT [EC:5.1.3.19]
synonym: "chondroitin-D-glucuronate 5-epimerase activity" EXACT [EC:5.1.3.19]
synonym: "dermatan-sulfate 5-epimerase activity" EXACT [EC:5.1.3.19]
synonym: "polyglucuronate 5-epimerase activity" RELATED [EC:5.1.3.19]
synonym: "urunosyl C-5 epimerase activity" EXACT [EC:5.1.3.19]
xref: EC:5.1.3.19
xref: MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047758
name: branched-chain fatty acid kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2-methylpropanoate = ADP + 2-methylpropanoyl phosphate." [EC:2.7.2.14, MetaCyc:BRANCHED-CHAIN-FATTY-ACID-KINASE-RXN]
synonym: "ATP:branched-chain-fatty-acid 1-phosphotransferase activity" EXACT [EC:2.7.2.14]
synonym: "branched-chain-fatty-acid kinase activity" EXACT []
synonym: "isobutyrate kinase activity" NARROW [EC:2.7.2.14]
xref: EC:2.7.2.14
xref: MetaCyc:BRANCHED-CHAIN-FATTY-ACID-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0047759
name: butanal dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+." [EC:1.2.1.57, MetaCyc:BUTANAL-DEHYDROGENASE-RXN]
synonym: "butanal:NAD(P)+ oxidoreductase (CoA-acylating)" EXACT [EC:1.2.1.57]
xref: EC:1.2.1.57
xref: MetaCyc:BUTANAL-DEHYDROGENASE-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047760
name: butyrate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA." [EC:6.2.1.2, MetaCyc:BUTYRATE--COA-LIGASE-RXN]
synonym: "acyl-activating enzyme activity" RELATED [EC:6.2.1.2]
synonym: "butanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.2]
synonym: "butyryl-CoA synthetase activity" EXACT [EC:6.2.1.2]
synonym: "butyryl-coenzyme A synthetase activity" EXACT [EC:6.2.1.2]
synonym: "fatty acid activating enzyme" RELATED [EC:6.2.1.2]
synonym: "fatty acid thiokinase (medium chain) activity" RELATED [EC:6.2.1.2]
synonym: "fatty acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.2]
synonym: "L-(+)-3-hydroxybutyryl CoA ligase activity" EXACT [EC:6.2.1.2]
synonym: "medium chain acyl-CoA synthetase activity" EXACT [EC:6.2.1.2]
synonym: "short-chain acyl-CoA synthetase activity" EXACT [EC:6.2.1.2]
xref: EC:6.2.1.2
xref: MetaCyc:BUTYRATE--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047761
name: butyrate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate." [EC:2.7.2.7, MetaCyc:BUTYRATE-KINASE-RXN]
subset: gosubset_prok
synonym: "ATP:butanoate 1-phosphotransferase activity" EXACT [EC:2.7.2.7]
xref: EC:2.7.2.7
xref: MetaCyc:BUTYRATE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0047762
name: caffeate 3,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxy-trans-cinnamate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate." [EC:1.13.11.22, MetaCyc:CAFFEATE-34-DIOXYGENASE-RXN]
synonym: "3,4-dihydroxy-trans-cinnamate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.22]
xref: EC:1.13.11.22
xref: MetaCyc:CAFFEATE-34-DIOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047763
name: caffeate O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate." [EC:2.1.1.68, MetaCyc:CAFFEATE-O-METHYLTRANSFERASE-RXN]
synonym: "caffeate 3-O-methyltransferase activity" EXACT [EC:2.1.1.68]
synonym: "caffeate methyltransferase activity" EXACT [EC:2.1.1.68]
synonym: "S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase activity" EXACT [EC:2.1.1.68]
synonym: "S-adenosyl-L-methionine:caffeic acid-O-methyltransferase activity" EXACT [EC:2.1.1.68]
xref: EC:2.1.1.68
xref: MetaCyc:RXN-1104
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0047764
name: caldesmon kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + caldesmon = ADP + caldesmon phosphate." [GOC:curators]
xref: MetaCyc:2.7.11.17-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0047765
name: caldesmon-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate." [EC:3.1.3.55, MetaCyc:CALDESMON-PHOSPHATASE-RXN]
synonym: "caldesmon-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.55]
synonym: "smooth muscle caldesmon phosphatase activity" EXACT [EC:3.1.3.55]
synonym: "SMP-I" RELATED [EC:3.1.3.55]
xref: EC:3.1.3.55
xref: MetaCyc:CALDESMON-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047766
name: carbamoyl-serine ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-carbamoyl-L-serine + H2O = pyruvate + 2 NH3 + CO2." [EC:4.3.1.13, MetaCyc:CARBAMOYL-SERINE-AMMONIA-LYASE-RXN]
synonym: "carbamoylserine deaminase activity" EXACT [EC:4.3.1.13]
synonym: "O-carbamoyl-L-serine ammonia-lyase (decarboxylating; pyruvate-forming)" EXACT [EC:4.3.1.13]
synonym: "O-carbamoyl-L-serine ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.13]
synonym: "O-carbamoyl-L-serine deaminase activity" EXACT [EC:4.3.1.13]
xref: EC:4.3.1.13
xref: MetaCyc:CARBAMOYL-SERINE-AMMONIA-LYASE-RXN
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0047768
name: carboxy-cis,cis-muconate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate." [EC:5.5.1.5, MetaCyc:CARBOXY-CISCIS-MUCONATE-CYCLASE-RXN]
synonym: "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.5]
synonym: "3-carboxy-cis,cis-muconate lactonizing enzyme activity" EXACT [EC:5.5.1.5]
synonym: "3-carboxymuconate cyclase activity" EXACT [EC:5.5.1.5]
xref: EC:5.5.1.5
xref: MetaCyc:CARBOXY-CISCIS-MUCONATE-CYCLASE-RXN
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0047769
name: arogenate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2." [EC:4.2.1.91, MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN]
subset: gosubset_prok
synonym: "carboxycyclohexadienyl dehydratase activity" EXACT []
synonym: "L-arogenate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.91]
synonym: "L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)" EXACT [EC:4.2.1.91]
xref: EC:4.2.1.91
xref: MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047770
name: carboxylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor." [EC:1.2.99.6, MetaCyc:CARBOXYLATE-REDUCTASE-RXN]
synonym: "aldehyde:(acceptor) oxidoreductase activity" EXACT [EC:1.2.99.6]
synonym: "aldehyde:acceptor oxidoreductase activity" EXACT [EC:1.2.99.6]
synonym: "carboxylic acid reductase activity" EXACT [EC:1.2.99.6]
xref: EC:1.2.99.6
xref: MetaCyc:CARBOXYLATE-REDUCTASE-RXN
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0047771
name: carboxymethylhydantoinase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-5-carboxymethylhydantoin + H2O = N-carbamoyl-L-aspartate." [EC:3.5.2.4, MetaCyc:CARBOXYMETHYLHYDANTOINASE-RXN]
synonym: "hydantoin hydrolase activity" EXACT [EC:3.5.2.4]
synonym: "L-5-carboxymethylhydantoin amidohydrolase activity" EXACT [EC:3.5.2.4]
xref: EC:3.5.2.4
xref: MetaCyc:CARBOXYMETHYLHYDANTOINASE-RXN
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0047772
name: carboxymethyloxysuccinate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 2 carboxymethyloxysuccinate = 2 glycolate + 2 fumarate." [EC:4.2.99.12, MetaCyc:CARBOXYMETHYLOXYSUCCINATE-LYASE-RXN]
synonym: "carboxymethyloxysuccinate glycolate-lyase (fumarate-forming)" EXACT [EC:4.2.99.12]
synonym: "carboxymethyloxysuccinate glycolate-lyase activity" EXACT [EC:4.2.99.12]
xref: EC:4.2.99.12
xref: MetaCyc:CARBOXYMETHYLOXYSUCCINATE-LYASE-RXN
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0047773
name: carnitinamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-carnitinamide + H2O = L-carnitine + NH3." [EC:3.5.1.73, MetaCyc:CARNITINAMIDASE-RXN]
synonym: "carnitine amidase activity" EXACT [EC:3.5.1.73]
synonym: "L-carnitinamidase activity" EXACT [EC:3.5.1.73]
synonym: "L-carnitinamide amidohydrolase activity" EXACT [EC:3.5.1.73]
synonym: "L-carnitine amidase activity" EXACT [EC:3.5.1.73]
xref: EC:3.5.1.73
xref: MetaCyc:CARNITINAMIDASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047774
name: cis-2-enoyl-CoA reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH." [EC:1.3.1.37, MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-NADPH-RXN]
synonym: "acyl-CoA:NADP+ cis-2-oxidoreductase activity" EXACT [EC:1.3.1.37]
synonym: "cis-2-enoyl-coenzyme A reductase activity" EXACT [EC:1.3.1.37]
synonym: "NADPH-dependent cis-enoyl-CoA reductase activity" EXACT [EC:1.3.1.37]
synonym: "reductase, cis-2-enoyl coenzyme A" EXACT [EC:1.3.1.37]
xref: EC:1.3.1.37
xref: MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-NADPH-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047775
name: citramalate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA." [EC:2.8.3.11, MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN]
synonym: "acetyl-CoA:citramalate CoA-transferase activity" EXACT [EC:2.8.3.11]
xref: EC:2.8.3.11
xref: MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0047776
name: citramalate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S)-citramalate = acetate + pyruvate." [EC:4.1.3.22, MetaCyc:CITRAMALATE-LYASE-RXN]
synonym: "(+)-citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22]
synonym: "(3S)-citramalate pyruvate-lyase (acetate-forming)" EXACT [EC:4.1.3.22]
synonym: "(3S)-citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22]
synonym: "(S)-citramalate lyase activity" EXACT [EC:4.1.3.22]
synonym: "citramalate pyruvate lyase activity" EXACT [EC:4.1.3.22]
synonym: "citramalate pyruvate-lyase activity" EXACT [EC:4.1.3.22]
synonym: "citramalate synthetase activity" EXACT [EC:4.1.3.22]
synonym: "citramalic synthase activity" EXACT [EC:4.1.3.22]
synonym: "citramalic-condensing enzyme" RELATED [EC:4.1.3.22]
xref: EC:4.1.3.22
xref: MetaCyc:CITRAMALATE-LYASE-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047777
name: (3S)-citramalyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate." [EC:4.1.3.25, MetaCyc:CITRAMALYL-COA-LYASE-RXN]
synonym: "(+)-CMA-CoA lyase activity" EXACT [EC:4.1.3.25]
synonym: "(3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.25]
synonym: "(3S)-citramalyl-CoA pyruvate-lyase activity" EXACT [EC:4.1.3.25]
synonym: "citramalyl coenzyme A lyase activity" EXACT [EC:4.1.3.25]
synonym: "citramalyl-CoA lyase activity" BROAD []
xref: EC:4.1.3.25
xref: MetaCyc:CITRAMALYL-COA-LYASE-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0047778
name: [citrate-(pro-3S)-lyase] thiolesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate." [EC:3.1.2.16, MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN]
synonym: "[citrate-(pro-3S)-lyase] thioesterase activity" EXACT [EC:3.1.2.16]
synonym: "citrate (pro-3S)-lyase thiolesterase activity" EXACT []
synonym: "citrate lyase deacetylase activity" EXACT [EC:3.1.2.16]
synonym: "citrate-(pro-3S)-lyase thioesterase activity" EXACT [EC:3.1.2.16]
synonym: "citrate-(pro-3S)-lyase thiolesterase activity" EXACT [EC:3.1.2.16]
synonym: "citrate-(pro-3S)-lyase(acetyl-form) hydrolase activity" EXACT [EC:3.1.2.16]
xref: EC:3.1.2.16
xref: MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0047779
name: citrate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA." [EC:6.2.1.18, MetaCyc:CITRATE--COA-LIGASE-RXN]
synonym: "citrate thiokinase activity" EXACT [EC:6.2.1.18]
synonym: "citrate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.18]
synonym: "citrate:CoA ligase activity" EXACT [EC:6.2.1.18]
synonym: "citryl-CoA synthetase activity" EXACT [EC:6.2.1.18]
xref: EC:6.2.1.18
xref: MetaCyc:CITRATE--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047780
name: citrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: citrate = cis-aconitate + H2O." [EC:4.2.1.4, MetaCyc:CITRATE-DEHYDRATASE-RXN]
synonym: "citrate hydro-lyase (cis-aconitate-forming)" EXACT [EC:4.2.1.4]
synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.4]
xref: EC:4.2.1.4
xref: MetaCyc:CITRATE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047781
name: citrullinase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine." [EC:3.5.1.20, MetaCyc:CITRULLINASE-RXN]
synonym: "citrulline hydrolase activity" EXACT [EC:3.5.1.20]
synonym: "citrulline ureidase activity" EXACT [EC:3.5.1.20]
synonym: "L-citrulline 5-N-carbamoyldihydrolase activity" EXACT [EC:3.5.1.20]
synonym: "L-citrulline N5-carbamoyldihydrolase activity" EXACT [EC:3.5.1.20]
xref: EC:3.5.1.20
xref: MetaCyc:CITRULLINASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047782
name: coniferin beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol." [EC:3.2.1.126, MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN]
synonym: "coniferin b-glucosidase activity" EXACT []
synonym: "coniferin beta-D-glucosidase activity" EXACT [EC:3.2.1.126]
synonym: "coniferin-hydrolyzing beta-glucosidase activity" EXACT [EC:3.2.1.126]
xref: EC:3.2.1.126
xref: MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047783
name: corticosterone 18-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.5, MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN]
synonym: "corticosterone 18-hydroxylase activity" EXACT []
synonym: "corticosterone methyl oxidase activity" RELATED [EC:1.14.15.5]
synonym: "corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)" EXACT [EC:1.14.15.5]
xref: EC:1.14.15.5
xref: MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047784
name: cortisol O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + cortisol = CoA + cortisol 21-acetate." [EC:2.3.1.27, MetaCyc:CORTISOL-O-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA:cortisol O-acetyltransferase activity" EXACT [EC:2.3.1.27]
synonym: "corticosteroid acetyltransferase activity" EXACT [EC:2.3.1.27]
synonym: "corticosteroid-21-O-acetyltransferase activity" EXACT [EC:2.3.1.27]
synonym: "cortisol acetyltransferase activity" EXACT [EC:2.3.1.27]
xref: EC:2.3.1.27
xref: MetaCyc:CORTISOL-O-ACETYLTRANSFERASE-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0047785
name: cortisol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + cortisol = adenosine 3',5'-bisphosphate + cortisol 21-sulfate." [EC:2.8.2.18, MetaCyc:CORTISOL-SULFOTRANSFERASE-RXN]
synonym: "3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase activity" EXACT [EC:2.8.2.18]
synonym: "cortisol sulphotransferase activity" EXACT []
synonym: "glucocorticoid sulfotransferase activity" EXACT [EC:2.8.2.18]
synonym: "glucocorticosteroid sulfotransferase activity" BROAD [EC:2.8.2.18]
xref: EC:2.8.2.18
xref: MetaCyc:CORTISOL-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047786
name: cortisone alpha-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,5-alpha-dihydrocortisone + NADP+ = cortisone + NADPH." [EC:1.3.1.4, MetaCyc:CORTISONE-ALPHA-REDUCTASE-RXN]
synonym: "4,5alpha-dihydrocortisone:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.4]
synonym: "cortisone a-reductase activity" EXACT []
synonym: "cortisone delta4-5alpha-reductase activity" EXACT [EC:1.3.1.4]
synonym: "delta4-3-ketosteroid reductase (5alpha)" EXACT [EC:1.3.1.4]
synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.1.4]
synonym: "delta4-5alpha-reductase activity" EXACT [EC:1.3.1.4]
synonym: "microsomal steroid reductase (5alpha)" EXACT [EC:1.3.1.4]
synonym: "NADPH:Delta4-3-oxosteroid-5alpha-oxidoreductase activity" EXACT [EC:1.3.1.4]
xref: EC:1.3.1.4
xref: MetaCyc:CORTISONE-ALPHA-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047787
name: delta4-3-oxosteroid 5beta-reductase activity
namespace: molecular_function
alt_id: GO:0047752
def: "Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+." [EC:1.3.1.3, MetaCyc:CORTISONE-BETA-REDUCTASE-RXN]
synonym: "3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.23]
synonym: "3-oxo-Delta(4)-steroid 5-beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "3-oxo-delta4-steroid 5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity" EXACT [EC:1.3.1.23]
synonym: "5-beta-reductase activity" BROAD [EC:1.3.1.23]
synonym: "5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity" EXACT [EC:1.3.1.23]
synonym: "5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "androstenedione 5-beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "androstenedione 5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "cholestenone 5-beta-reductase activity" EXACT []
synonym: "cholestenone 5b-reductase activity" EXACT []
synonym: "cholestenone 5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "cortisone 5-beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "cortisone 5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "cortisone b-reductase activity" EXACT []
synonym: "cortisone beta-reductase activity" EXACT []
synonym: "cortisone delta(4)-5-beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "cortisone delta4-5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "delta(4)-3-ketosteroid 5-beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "delta(4)-5-beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "delta(4)-hydrogenase activity" EXACT [EC:1.3.1.23]
synonym: "delta-4-3-oxosteroid 5-beta-reductase activity" EXACT []
synonym: "delta4-3-ketosteroid 5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "delta4-5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "delta4-hydrogenase activity" EXACT [EC:1.3.1.23]
synonym: "steroid 5-beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "steroid 5beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "testosterone 5-beta-reductase activity" EXACT [EC:1.3.1.23]
synonym: "testosterone 5beta-reductase activity" EXACT [EC:1.3.1.23]
xref: EC:1.3.1.3
xref: MetaCyc:CHOLESTENONE-5-BETA-REDUCTASE-RXN
xref: MetaCyc:CORTISONE-BETA-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047788
name: 2-coumarate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD+ = 2-coumarate + NADH." [EC:1.3.1.11, MetaCyc:COUMARATE-REDUCTASE-RXN]
synonym: "3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.11]
synonym: "coumarate reductase activity" EXACT []
synonym: "melilotate dehydrogenase activity" EXACT [EC:1.3.1.11]
xref: EC:1.3.1.11
xref: MetaCyc:COUMARATE-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047789
name: creatininase activity
namespace: molecular_function
def: "Catalysis of the reaction: creatinine + H2O = creatine." [EC:3.5.2.10, MetaCyc:CREATININASE-RXN]
subset: gosubset_prok
synonym: "creatinine amidohydrolase activity" EXACT [EC:3.5.2.10]
synonym: "creatinine hydrolase" BROAD [EC:3.5.2.10]
xref: EC:3.5.2.10
xref: MetaCyc:CREATININASE-RXN
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0047790
name: creatinine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3." [EC:3.5.4.21, MetaCyc:CREATININE-DEAMINASE-RXN]
subset: gosubset_prok
synonym: "creatinine desiminase activity" EXACT [EC:3.5.4.21]
synonym: "creatinine hydrolase" BROAD [EC:3.5.4.21]
synonym: "creatinine iminohydrolase activity" EXACT [EC:3.5.4.21]
xref: EC:3.5.4.21
xref: MetaCyc:CREATININE-DEAMINASE-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047791
name: cucurbitacin delta23-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+." [EC:1.3.1.5, MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN]
synonym: "23,24-dihydrocucurbitacin:NAD(P)+ delta23-oxidoreductase activity" EXACT [EC:1.3.1.5]
synonym: "cucurbitacin D23-reductase activity" EXACT []
synonym: "cucurbitacin delta(23) reductase activity" EXACT []
synonym: "NAD(P)H: cucurbitacin B delta23-oxidoreductase activity" EXACT [EC:1.3.1.5]
xref: EC:1.3.1.5
xref: MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047792
name: cyanohydrin beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDPglucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxy-mandelonitrile beta-D-glucoside." [EC:2.4.1.85, MetaCyc:CYANOHYDRIN-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "cyanohydrin b-glucosyltransferase activity" EXACT []
synonym: "UDP-D-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.85]
synonym: "UDP-glucose-p-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.85]
synonym: "UDP-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.85]
synonym: "UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase activity" EXACT [EC:2.4.1.85]
synonym: "UGT85B1 activity" NARROW [EC:2.4.1.85]
synonym: "uridine diphosphoglucose-cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.85]
synonym: "uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase activity" EXACT [EC:2.4.1.85]
synonym: "uridine diphosphoglucose:aldehyde cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.85]
xref: EC:2.4.1.85
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047793
name: cycloeucalenol cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: cycloeucalenol = obtusifoliol." [EC:5.5.1.9, MetaCyc:CYCLOEUCALENOL-CYCLOISOMERASE-RXN]
synonym: "cycloeucalenol lyase (cyclopropane-decyclizing)" EXACT [EC:5.5.1.9]
synonym: "cycloeucalenol--obtusifoliol isomerase activity" EXACT [EC:5.5.1.9]
synonym: "cycloeucalenol-obtusifoliol isomerase activity" EXACT []
xref: EC:5.5.1.9
xref: MetaCyc:CYCLOEUCALENOL-CYCLOISOMERASE-RXN
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0047794
name: cyclohexadienyl dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arogenate + NAD+ = L-tyrosine + NADH + CO2." [EC:1.3.1.43, MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "arogenate dehydrogenase activity" EXACT [EC:1.3.1.43]
synonym: "arogenic dehydrogenase activity" EXACT [EC:1.3.1.43]
synonym: "L-arogenate:NAD(+) oxidoreductase activity" EXACT [EC:1.3.1.43]
synonym: "L-arogenate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.43]
synonym: "L-arogenate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.43]
synonym: "pretyrosine dehydrogenase activity" EXACT [EC:1.3.1.43]
xref: EC:1.3.1.43
xref: MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047795
name: cyclohexane-1,2-diol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH." [EC:1.1.1.174, MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN]
synonym: "trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.174]
xref: EC:1.1.1.174
xref: MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047796
name: cyclohexane-1,3-dione hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexane-1,3-dione + H2O = 5-oxohexanoate." [EC:3.7.1.10, MetaCyc:CYCLOHEXANE-13-DIONE-HYDROLASE-RXN]
synonym: "1,3-cyclohexanedione hydrolase activity" EXACT [EC:3.7.1.10]
synonym: "cyclohexane-1,3-dione acylhydrolase (decyclizing)" EXACT [EC:3.7.1.10]
xref: EC:3.7.1.10
xref: MetaCyc:CYCLOHEXANE-13-DIONE-HYDROLASE-RXN
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0047797
name: cyclohexanone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclohexanone + acceptor = cyclohex-2-enone + reduced acceptor." [EC:1.3.99.14, MetaCyc:CYCLOHEXANONE-DEHYDROGENASE-RXN]
synonym: "cyclohexanone:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.3.99.14]
synonym: "cyclohexanone:acceptor 2-oxidoreductase activity" EXACT [EC:1.3.99.14]
xref: EC:1.3.99.14
xref: MetaCyc:CYCLOHEXANONE-DEHYDROGENASE-RXN
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0047798
name: cyclomaltodextrinase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin." [EC:3.2.1.54, MetaCyc:CYCLOMALTODEXTRINASE-RXN]
subset: gosubset_prok
synonym: "cyclodextrinase activity" EXACT [EC:3.2.1.54]
synonym: "cycloheptaglucanase activity" EXACT [EC:3.2.1.54]
synonym: "cyclohexaglucanase activity" EXACT [EC:3.2.1.54]
synonym: "cyclomaltodextrin dextrin-hydrolase (decyclizing)" EXACT [EC:3.2.1.54]
xref: EC:3.2.1.54
xref: MetaCyc:CYCLOMALTODEXTRINASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047799
name: cyclopentanone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclopentanone + NADPH + O2 = 5-valerolactone + NADP+ + H2O." [EC:1.14.13.16, MetaCyc:CYCLOPENTANONE-MONOOXYGENASE-RXN]
synonym: "cyclopentanone 1,2-monooxygenase activity" EXACT [EC:1.14.13.16]
synonym: "cyclopentanone oxygenase activity" EXACT [EC:1.14.13.16]
synonym: "cyclopentanone,NADPH:oxygen oxidoreductase (5-hydroxylating, lactonizing)" EXACT [EC:1.14.13.16]
xref: EC:1.14.13.16
xref: MetaCyc:CYCLOPENTANONE-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047800
name: cysteamine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cysteamine + O2 = hypotaurine." [EC:1.13.11.19, MetaCyc:CYSTEAMINE-DIOXYGENASE-RXN]
synonym: "2-aminoethanethiol:oxygen oxidoreductase activity" EXACT [EC:1.13.11.19]
synonym: "cysteamine oxygenase activity" EXACT [EC:1.13.11.19]
synonym: "cysteamine:oxygen oxidoreductase activity" EXACT [EC:1.13.11.19]
synonym: "persulfurase activity" RELATED [EC:1.13.11.19]
xref: EC:1.13.11.19
xref: MetaCyc:CYSTEAMINE-DIOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047801
name: L-cysteine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate." [EC:2.6.1.3, MetaCyc:CYSTEINE-AMINOTRANSFERASE-RXN]
synonym: "CGT" RELATED [EC:2.6.1.3]
synonym: "cysteine aminotransferase activity" BROAD []
synonym: "cysteine transaminase activity" BROAD [EC:2.6.1.3]
synonym: "L-cysteine aminotransferase activity" BROAD [EC:2.6.1.3]
xref: EC:2.6.1.3
xref: MetaCyc:CYSTEINE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047802
name: cysteine-conjugate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-(4-bromophenyl)-L-cysteine + 2-oxoglutarate = S-(4-bromophenyl)-mercaptopyruvate + L-glutamate." [EC:2.6.1.75, MetaCyc:CYSTEINE-CONJUGATE-TRANSAMINASE-RXN]
synonym: "cysteine conjugate aminotransferase activity" EXACT [EC:2.6.1.75]
synonym: "cysteine-conjugate alpha-ketoglutarate transaminase (CAT-1)" EXACT [EC:2.6.1.75]
synonym: "S-(4-bromophenyl)-L-cysteine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.75]
xref: EC:2.6.1.75
xref: MetaCyc:CYSTEINE-CONJUGATE-TRANSAMINASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047803
name: cysteine lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + SO3(2-) (sulfite) = L-cysteate + sulfide." [EC:4.4.1.10, MetaCyc:CYSTEINE-LYASE-RXN]
synonym: "cysteine (sulfite) lyase activity" EXACT [EC:4.4.1.10]
synonym: "L-cysteine hydrogen-sulfide-lyase (adding sulfite)" EXACT [EC:4.4.1.10]
synonym: "L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)" EXACT [EC:4.4.1.10]
xref: EC:4.4.1.10
xref: MetaCyc:CYSTEINE-LYASE-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0047804
name: cysteine-S-conjugate beta-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate." [EC:4.4.1.13, MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN]
subset: gosubset_prok
synonym: "cysteine conjugate beta-lyase activity" EXACT [EC:4.4.1.13]
synonym: "cysteine-S-conjugate b-lyase activity" EXACT []
synonym: "glutamine transaminase K/cysteine conjugate beta-lyase activity" EXACT [EC:4.4.1.13]
synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating) activity" EXACT [EC:4.4.1.13]
synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.13]
xref: EC:4.4.1.13
xref: MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0047805
name: cytidylate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate." [EC:4.6.1.6, MetaCyc:CYTIDYLATE-CYCLASE-RXN]
synonym: "3',5'-cyclic-CMP synthase activity" EXACT [EC:4.6.1.6]
synonym: "3'5'-cyclic-CMP synthase activity" EXACT [EC:4.6.1.6]
synonym: "CTP diphosphate-lyase (cyclizing)" EXACT [EC:4.6.1.6]
synonym: "CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)" EXACT [EC:4.6.1.6]
synonym: "cytidyl cyclase activity" EXACT [EC:4.6.1.6]
synonym: "cytidylyl cyclase activity" EXACT [EC:4.6.1.6]
xref: EC:4.6.1.6
xref: MetaCyc:CYTIDYLATE-CYCLASE-RXN
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016849 ! phosphorus-oxygen lyase activity

[Term]
id: GO:0047806
name: cytochrome-c3 hydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3." [EC:1.12.2.1, MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN]
subset: gosubset_prok
synonym: "cytochrome c3 reductase activity" EXACT [EC:1.12.2.1]
synonym: "cytochrome hydrogenase activity" BROAD [EC:1.12.2.1]
synonym: "H(2):ferricytochrome c3 oxidoreductase activity" EXACT [EC:1.12.2.1]
synonym: "H2:ferricytochrome c3 oxidoreductase activity" EXACT [EC:1.12.2.1]
synonym: "hydrogen:ferricytochrome-c3 oxidoreductase activity" EXACT [EC:1.12.2.1]
xref: EC:1.12.2.1
xref: MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0481
is_a: GO:0016697 ! oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor

[Term]
id: GO:0047807
name: cytokinin 7-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + N6-alkylaminopurine = UDP + N6-alkylaminopurine-7-beta-D-glucoside." [EC:2.4.1.118, MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "cytokinin 7-b-glucosyltransferase activity" EXACT []
synonym: "cytokinin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118]
synonym: "UDP-glucose-zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118]
synonym: "UDP-glucose:zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118]
synonym: "UDPglucose:zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118]
synonym: "uridine diphosphoglucose-zeatin 7-glucosyltransferase activity" EXACT [EC:2.4.1.118]
xref: EC:2.4.1.118
xref: MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047808
name: D(-)-tartrate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S,S)-tartrate = oxaloacetate + H2O." [EC:4.2.1.81, MetaCyc:D--TARTRATE-DEHYDRATASE-RXN]
synonym: "(S,S)-tartrate hydro-lyase (oxaloacetate-forming)" EXACT [EC:4.2.1.81]
synonym: "(S,S)-tartrate hydro-lyase activity" EXACT [EC:4.2.1.81]
synonym: "D-tartrate dehydratase activity" EXACT [EC:4.2.1.81]
xref: EC:4.2.1.81
xref: MetaCyc:D--TARTRATE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047809
name: D-2-hydroxy-acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-lactate + acceptor = pyruvate + reduced acceptor." [EC:1.1.99.6, MetaCyc:D-2-HYDROXY-ACID-DEHYDROGENASE-RXN]
synonym: "(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.6]
synonym: "2-hydroxy acid dehydrogenase activity" EXACT [EC:1.1.99.6]
xref: EC:1.1.99.6
xref: MetaCyc:D-2-HYDROXY-ACID-DEHYDROGENASE-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047810
name: D-alanine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate." [EC:2.6.1.21, MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN]
subset: gosubset_prok
synonym: "D-alanine aminotransferase activity" EXACT []
synonym: "D-alanine transaminase activity" BROAD [EC:2.6.1.21]
synonym: "D-alanine-D-glutamate transaminase activity" EXACT [EC:2.6.1.21]
synonym: "D-amino acid aminotransferase activity" BROAD [EC:2.6.1.21]
synonym: "D-amino acid transaminase activity" BROAD [EC:2.6.1.21]
synonym: "D-amino-acid transaminase activity" BROAD [EC:2.6.1.21]
synonym: "D-aspartate aminotransferase activity" RELATED [EC:2.6.1.21]
synonym: "D-aspartate transaminase activity" RELATED [EC:2.6.1.21]
synonym: "D-aspartic aminotransferase activity" RELATED [EC:2.6.1.21]
xref: EC:2.6.1.21
xref: MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047811
name: D-alanine gamma-glutamyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + D-alanine = NH3 + g-L-glutamyl-D-alanine." [EC:2.3.2.14, MetaCyc:D-ALANINE-GAMMA-GLUTAMYLTRANSFERASE-RXN]
synonym: "D-alanine g-glutamyltransferase activity" EXACT []
synonym: "L-glutamine:D-alanine gamma-glutamyltransferase activity" EXACT [EC:2.3.2.14]
xref: EC:2.3.2.14
xref: MetaCyc:D-ALANINE-GAMMA-GLUTAMYLTRANSFERASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0047812
name: D-amino-acid N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino-acid." [EC:2.3.1.36, MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA:D-amino-acid N-acetyltransferase activity" EXACT [EC:2.3.1.36]
synonym: "D-amino acid acetyltransferase activity" EXACT [EC:2.3.1.36]
synonym: "D-amino acid-alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.36]
xref: EC:2.3.1.36
xref: MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047813
name: D-arabinitol 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH." [EC:1.1.1.11, MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN]
subset: gosubset_prok
xref: EC:1.1.1.11
xref: MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047814
name: D-arabinokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-arabinose = ADP + D-arabinose 5-phosphate." [EC:2.7.1.54, MetaCyc:D-ARABINOKINASE-RXN]
synonym: "ATP:D-arabinose 5-phosphotransferase activity" EXACT [EC:2.7.1.54]
synonym: "D-arabinokinase (phosphorylating)" EXACT [EC:2.7.1.54]
xref: EC:2.7.1.54
xref: MetaCyc:D-ARABINOKINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047815
name: D-arabinonolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinono-1,4-lactone + H2O = D-arabinonate." [EC:3.1.1.30, MetaCyc:D-ARABINONOLACTONASE-RXN]
synonym: "D-arabinono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.30]
xref: EC:3.1.1.30
xref: MetaCyc:D-ARABINONOLACTONASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047816
name: D-arabinose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH." [EC:1.1.1.116, MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN]
synonym: "arabinose(fucose)dehydrogenase activity" EXACT [EC:1.1.1.116]
synonym: "D-arabinose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.116]
synonym: "NAD-pentose-dehydrogenase activity" EXACT [EC:1.1.1.116]
xref: EC:1.1.1.116
xref: MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047817
name: D-arginase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-arginine + H2O = D-ornithine + urea." [EC:3.5.3.10, MetaCyc:D-ARGINASE-RXN]
synonym: "D-arginine amidinohydrolase activity" EXACT [EC:3.5.3.10]
xref: EC:3.5.3.10
xref: MetaCyc:D-ARGINASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047818
name: D-fuconate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H2O." [EC:4.2.1.67, MetaCyc:D-FUCONATE-HYDRATASE-RXN]
synonym: "D-fuconate hydratase activity" EXACT []
synonym: "D-fuconate hydro-lyase (2-dehydro-3-deoxy-D-fuconate-forming)" EXACT [EC:4.2.1.67]
synonym: "D-fuconate hydro-lyase activity" EXACT [EC:4.2.1.67]
xref: EC:4.2.1.67
xref: MetaCyc:D-FUCONATE-HYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047819
name: D-glutamate(D-aspartate) oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2." [EC:1.4.3.15, MetaCyc:D-GLUTAMATED-ASPARTATE-OXIDASE-RXN]
synonym: "D-glutamate(D-aspartate):oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.15]
synonym: "D-glutamic-aspartic oxidase activity" EXACT [EC:1.4.3.15]
synonym: "D-monoaminodicarboxylic acid oxidase activity" EXACT [EC:1.4.3.15]
xref: EC:1.4.3.15
xref: MetaCyc:D-GLUTAMATED-ASPARTATE-OXIDASE-RXN
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0047820
name: D-glutamate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H2O." [EC:4.2.1.48, MetaCyc:D-GLUTAMATE-CYCLASE-RXN]
synonym: "D-glutamate hydro-lyase (cyclizing)" EXACT [EC:4.2.1.48]
synonym: "D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)" EXACT [EC:4.2.1.48]
xref: EC:4.2.1.48
xref: MetaCyc:D-GLUTAMATE-CYCLASE-RXN
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047821
name: D-glutamate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2; D-aspartate + H2O = oxaloacetate + NH3 + H2O2." [BRENDA:1.4.3.15, EC:1.4.3.7, MetaCyc:D-GLUTAMATE-OXIDASE-RXN]
synonym: "D-glutamate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.7]
synonym: "D-glutamic acid oxidase activity" EXACT [EC:1.4.3.7]
synonym: "D-glutamic oxidase activity" EXACT [EC:1.4.3.7]
xref: EC:1.4.3.7
xref: MetaCyc:D-GLUTAMATE-OXIDASE-RXN
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0047822
name: hypotaurine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hypotaurine + H2O + NAD+ = taurine + NADH." [EC:1.8.1.3, MetaCyc:HYPOTAURINE-DEHYDROGENASE-RXN]
synonym: "hypotaurine:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.3]
xref: EC:1.8.1.3
xref: MetaCyc:HYPOTAURINE-DEHYDROGENASE-RXN
is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047823
name: D-glutamyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L(or D)-glutamine + D-glutamyl-peptide = NH3 + 5-glutamyl-D-glutamyl-peptide." [EC:2.3.2.1, MetaCyc:D-GLUTAMYLTRANSFERASE-RXN]
synonym: "D-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.1]
synonym: "D-glutamyl transpeptidase activity" EXACT [EC:2.3.2.1]
synonym: "glutamine:D-glutamyl-peptide 5-glutamyltransferase activity" EXACT [EC:2.3.2.1]
xref: EC:2.3.2.1
xref: MetaCyc:D-GLUTAMYLTRANSFERASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0047824
name: D-iditol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH." [EC:1.1.1.15, MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN]
xref: EC:1.1.1.15
xref: MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
is_a: GO:0031320 ! hexitol dehydrogenase activity

[Term]
id: GO:0047825
name: D-lactate-2-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-O-sulfolactate + H2O = (S)-lactate + SO4(2-) (sulfate)." [EC:3.1.6.17, MetaCyc:D-LACTATE-2-SULFATASE-RXN]
synonym: "(S)-2-O-sulfolactate 2-sulfohydrolase activity" EXACT [EC:3.1.6.17]
synonym: "D-lactate-2-sulphatase activity" EXACT []
xref: EC:3.1.6.17
xref: MetaCyc:D-LACTATE-2-SULFATASE-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0047826
name: D-lysine 5,6-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-lysine = 2,5-diaminohexanoate." [EC:5.4.3.4, MetaCyc:D-LYSINE-56-AMINOMUTASE-RXN]
synonym: "adenosylcobalamin-dependent D-lysine 5,6-aminomutase activity" EXACT [EC:5.4.3.4]
synonym: "D-2,6-diaminohexanoate 5,6-aminomutase activity" EXACT [EC:5.4.3.4]
synonym: "D-alpha-lysine mutase activity" EXACT [EC:5.4.3.4]
xref: EC:5.4.3.4
xref: MetaCyc:D-LYSINE-56-AMINOMUTASE-RXN
is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups

[Term]
id: GO:0047827
name: D-lysopine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-lysine + NADP+ + H2O = L-lysine + pyruvate + NADPH." [EC:1.5.1.16, MetaCyc:D-LYSOPINE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.16]
synonym: "D(+)-lysopine dehydrogenase activity" EXACT [EC:1.5.1.16]
synonym: "D-lysopine synthase activity" EXACT [EC:1.5.1.16]
synonym: "lysopine dehydrogenase activity" EXACT [EC:1.5.1.16]
synonym: "N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.16]
xref: EC:1.5.1.16
xref: MetaCyc:D-LYSOPINE-DEHYDROGENASE-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047828
name: D-lyxose ketol-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-lyxose = D-xylulose." [EC:5.3.1.15, MetaCyc:D-LYXOSE-KETOL-ISOMERASE-RXN]
synonym: "D-lyxose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.15]
synonym: "D-lyxose isomerase activity" EXACT [EC:5.3.1.15]
xref: EC:5.3.1.15
xref: MetaCyc:D-LYXOSE-KETOL-ISOMERASE-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0047829
name: D-nopaline dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH." [EC:1.5.1.19, MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "2-N-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.19]
synonym: "D-nopaline synthase activity" EXACT [EC:1.5.1.19]
synonym: "N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.19]
synonym: "nopaline dehydrogenase activity" EXACT [EC:1.5.1.19]
synonym: "nopaline synthase activity" EXACT [EC:1.5.1.19]
synonym: "NOS activity" EXACT [EC:1.5.1.19]
xref: EC:1.5.1.19
xref: MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047830
name: D-octopine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH." [EC:1.5.1.11, MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "2-N-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.11]
synonym: "D-octopine synthase activity" EXACT [EC:1.5.1.11]
synonym: "N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)" EXACT [EC:1.5.1.11]
synonym: "octopine dehydrogenase activity" EXACT [EC:1.5.1.11]
synonym: "octopine:NAD oxidoreductase activity" EXACT [EC:1.5.1.11]
synonym: "ODH activity" EXACT [EC:1.5.1.11]
xref: EC:1.5.1.11
xref: MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047831
name: D-ornithine 4,5-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ornithine = (2R,4S)-2,4-diaminopentanoate." [EC:5.4.3.5, MetaCyc:ORNMUTST-RXN]
synonym: "D-alpha-ornithine 5,4-aminomutase activity" EXACT [EC:5.4.3.5]
synonym: "D-ornithine aminomutase activity" EXACT [EC:5.4.3.5]
xref: EC:5.4.3.5
xref: MetaCyc:ORNMUTST-RXN
is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups

[Term]
id: GO:0047832
name: D-pinitol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5D-5-O-methyl-chiro-inositol + NADP+ = 5D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADPH." [EC:1.1.1.142, MetaCyc:D-PINITOL-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "1D-3-O-methyl-chiro-inositol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.142]
synonym: "5D-5-O-methyl-chiro-inositol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.142]
xref: EC:1.1.1.142
xref: MetaCyc:D-PINITOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047833
name: D-sorbitol dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor." [EC:1.1.99.21, MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN]
synonym: "D-sorbitol dehydrogenase activity" EXACT []
synonym: "D-sorbitol:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.21]
synonym: "D-sorbitol:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.21]
xref: EC:1.1.99.21
xref: MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047834
name: D-threo-aldose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH." [EC:1.1.1.122, MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "(2S,3R)-aldose dehydrogenase activity" EXACT [EC:1.1.1.122]
synonym: "D-threo-aldose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.122]
synonym: "dehydrogenase, L-fucose" EXACT [EC:1.1.1.122]
synonym: "L-fucose (D-arabinose) dehydrogenase activity" EXACT [EC:1.1.1.122]
synonym: "L-fucose dehydrogenase activity" EXACT [EC:1.1.1.122]
xref: EC:1.1.1.122
xref: MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047835
name: D-tryptophan N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + D-tryptophan = CoA + N-acetyl-D-tryptophan." [EC:2.3.1.34, MetaCyc:D-TRYPTOPHAN-N-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA-D-tryptophan-alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.34]
synonym: "acetyl-CoA:D-tryptophan N-acetyltransferase activity" EXACT [EC:2.3.1.34]
synonym: "D-tryptophan acetyltransferase activity" EXACT [EC:2.3.1.34]
xref: EC:2.3.1.34
xref: MetaCyc:D-TRYPTOPHAN-N-ACETYLTRANSFERASE-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047836
name: D-tryptophan N-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonyl-CoA + D-tryptophan = CoA + N2-malonyl-D-tryptophan." [EC:2.3.1.112, MetaCyc:D-TRYPTOPHAN-N-MALONYLTRANSFERASE-RXN]
synonym: "malonyl-CoA:D-tryptophan N-malonyltransferase activity" EXACT [EC:2.3.1.112]
xref: EC:2.3.1.112
xref: MetaCyc:D-TRYPTOPHAN-N-MALONYLTRANSFERASE-RXN
is_a: GO:0050735 ! N-malonyltransferase activity

[Term]
id: GO:0047837
name: D-xylose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH." [EC:1.1.1.179, MetaCyc:D-XYLOSE-1-DEHYDROGENASE-NADP+-RXN]
subset: gosubset_prok
synonym: "D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.179]
synonym: "D-xylose-NADP dehydrogenase activity" EXACT [EC:1.1.1.179]
synonym: "D-xylose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.179]
synonym: "D-xylose:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.179]
xref: EC:1.1.1.179
xref: MetaCyc:D-XYLOSE-1-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047838
name: D-xylose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH." [EC:1.1.1.175, MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN]
synonym: "(NAD)-linked D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175]
synonym: "D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175]
synonym: "D-xylose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.175]
synonym: "NAD-D-xylose" RELATED [EC:1.1.1.175]
synonym: "NAD-D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175]
synonym: "NAD-linked D-xylose dehydrogenase activity" EXACT [EC:1.1.1.175]
xref: EC:1.1.1.175
xref: MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047839
name: dATP(dGTP)-DNA purinetransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dATP + depurinated DNA = ribose triphosphate + DNA." [EC:2.6.99.1, MetaCyc:DATPDGTP--DNA-PURINE-TRANSFERASE-RXN]
synonym: "dATP(dGTP)--DNA purine transferase activity" EXACT []
synonym: "dATP(dGTP):depurinated-DNA purine transferase activity" EXACT [EC:2.6.99.1]
xref: EC:2.6.99.1
xref: MetaCyc:DATPDGTP--DNA-PURINE-TRANSFERASE-RXN
is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups

[Term]
id: GO:0047840
name: dCTP diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dCTP + H2O = dCMP + diphosphate." [EC:3.6.1.12, MetaCyc:DCTP-PYROPHOSPHATASE-RXN]
synonym: "dCTP nucleotidohydrolase activity" EXACT [EC:3.6.1.12]
synonym: "dCTP pyrophosphatase activity" EXACT []
synonym: "dCTPase activity" EXACT [EC:3.6.1.12]
synonym: "deoxy-CTPase activity" EXACT [EC:3.6.1.12]
synonym: "deoxycytidine triphosphatase activity" EXACT [EC:3.6.1.12]
synonym: "deoxycytidine-triphosphatase activity" EXACT [EC:3.6.1.12]
xref: EC:3.6.1.12
xref: MetaCyc:DCTP-PYROPHOSPHATASE-RXN
is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity

[Term]
id: GO:0047841
name: dehydrogluconokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 2-dehydro-D-gluconate = ADP + 6-phospho-2-dehydro-D-gluconate." [EC:2.7.1.13, MetaCyc:DEHYDOGLUCONOKINASE-RXN]
synonym: "2-ketogluconate kinase activity" EXACT [EC:2.7.1.13]
synonym: "2-ketogluconokinase activity" EXACT [EC:2.7.1.13]
synonym: "ATP:2-dehydro-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.13]
synonym: "dehydogluconokinase activity" EXACT []
synonym: "ketogluconokinase (phosphorylating)" EXACT [EC:2.7.1.13]
synonym: "ketogluconokinase activity" EXACT [EC:2.7.1.13]
xref: EC:2.7.1.13
xref: MetaCyc:DEHYDOGLUCONOKINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047842
name: dehydro-L-gulonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-dehydro-L-gulonate = L-xylulose + CO2." [EC:4.1.1.34, MetaCyc:DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN]
synonym: "3-dehydro-L-gulonate carboxy-lyase (L-xylulose-forming)" EXACT [EC:4.1.1.34]
synonym: "3-dehydro-L-gulonate carboxy-lyase activity" EXACT [EC:4.1.1.34]
synonym: "3-keto-L-gulonate decarboxylase activity" EXACT [EC:4.1.1.34]
synonym: "keto-L-gulonate decarboxylase activity" EXACT [EC:4.1.1.34]
xref: EC:4.1.1.34
xref: MetaCyc:DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047843
name: dehydrogluconate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-D-gluconate + acceptor = 2,5-didehydro-D-gluconate + reduced acceptor." [EC:1.1.99.4, MetaCyc:DEHYDROGLUCONATE-DEHYDROGENASE-RXN]
synonym: "2-dehydro-D-gluconate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.4]
synonym: "2-keto-D-gluconate dehydrogenase activity" EXACT [EC:1.1.99.4]
synonym: "2-oxogluconate dehydrogenase activity" EXACT [EC:1.1.99.4]
synonym: "alpha-ketogluconate dehydrogenase activity" EXACT [EC:1.1.99.4]
synonym: "ketogluconate dehydrogenase activity" EXACT [EC:1.1.99.4]
xref: EC:1.1.99.4
xref: MetaCyc:DEHYDROGLUCONATE-DEHYDROGENASE-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047844
name: deoxycytidine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3." [EC:3.5.4.14, MetaCyc:DEOXYCYTIDINE-DEAMINASE-RXN]
subset: gosubset_prok
synonym: "deoxycytidine aminohydrolase activity" EXACT [EC:3.5.4.14]
xref: EC:3.5.4.14
xref: MetaCyc:CYTIDEAM-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047845
name: deoxylimonate A-ring-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxylimonate + H2O = deoxylimononic acid D-ring-lactone." [EC:3.1.1.46, MetaCyc:DEOXYLIMONATE-A-RING-LACTONASE-RXN]
synonym: "deoxylimonate A-ring-lactonohydrolase activity" EXACT [EC:3.1.1.46]
xref: EC:3.1.1.46
xref: MetaCyc:DEOXYLIMONATE-A-RING-LACTONASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047846
name: deoxynucleotide 3'-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate." [EC:3.1.3.34, MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN]
synonym: "3'-deoxynucleotidase activity" EXACT [EC:3.1.3.34]
synonym: "3'-deoxyribonucleotidase activity" EXACT [EC:3.1.3.34]
synonym: "deoxyribonucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.34]
xref: EC:3.1.3.34
xref: MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047847
name: deoxyuridine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate." [EC:2.4.2.23, MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN]
synonym: "2'-deoxyuridine:phosphate 2-deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.23]
synonym: "deoxyuridine:phosphate deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.23]
synonym: "deoxyuridine:phosphate deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.23]
xref: EC:2.4.2.23
xref: MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0047848
name: dephospho-[reductase kinase] kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] = ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]." [EC:2.7.11.3, MetaCyc:DEPHOSPHO-REDUCTASE-KINASE-KINASE-RXN]
synonym: "AMP-activated kinase activity" EXACT [EC:2.7.11.3]
synonym: "AMP-activated protein kinase kinase activity" EXACT [EC:2.7.11.3]
synonym: "ATP:dephospho-{hydroxymethylglutaryl-CoA reductase (NADPH)kinase} phosphotransferase activity" EXACT [EC:2.7.11.3]
synonym: "dephospho-reductase kinase kinase activity" EXACT [EC:2.7.11.3]
synonym: "hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating) activity" EXACT [EC:2.7.11.3]
synonym: "hydroxymethylglutaryl coenzyme A reductase kinase kinase activity" EXACT [EC:2.7.11.3]
synonym: "reductase kinase activity" BROAD [EC:2.7.11.3]
synonym: "reductase kinase kinase activity" EXACT [EC:2.7.11.3]
synonym: "STK30" RELATED [EC:2.7.11.3]
xref: EC:2.7.11.3
xref: MetaCyc:DEPHOSPHO-REDUCTASE-KINASE-KINASE-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0047849
name: dextransucrase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = D-fructose + 1,6-alpha-D-glucosyl(n+1)." [EC:2.4.1.5, MetaCyc:DEXTRANSUCRASE-RXN]
subset: gosubset_prok
synonym: "CEP" RELATED [EC:2.4.1.5]
synonym: "SGE" RELATED [EC:2.4.1.5]
synonym: "sucrose 6-glucosyltransferase activity" EXACT [EC:2.4.1.5]
synonym: "sucrose-1,6-alpha-glucan glucosyltransferase activity" EXACT [EC:2.4.1.5]
synonym: "sucrose:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.5]
xref: EC:2.4.1.5
xref: MetaCyc:DEXTRANSUCRASE-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0047850
name: diaminopimelate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: meso-2,6-diaminoheptanedioate + H2O + NADP+ = L-2-amino-6-oxoheptanedioate + NH3 + NADPH." [EC:1.4.1.16, MetaCyc:DIAMINOPIMELATE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.16]
synonym: "meso-alpha,epsilon-diaminopimelate dehydrogenase activity" EXACT [EC:1.4.1.16]
synonym: "meso-diaminopimelate D-dehydrogenase activity" EXACT [EC:1.4.1.16]
synonym: "meso-diaminopimelate dehydrogenase activity" EXACT [EC:1.4.1.16]
xref: EC:1.4.1.16
xref: MetaCyc:DIAMINOPIMELATE-DEHYDROGENASE-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047851
name: dicarboxylate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + an omega-dicarboxylic acid = AMP + diphosphate + an omega-carboxyacyl-CoA." [EC:6.2.1.23, MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN]
synonym: "carboxylyl-CoA synthetase activity" EXACT [EC:6.2.1.23]
synonym: "omega-dicarboxylate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.23]
xref: EC:6.2.1.23
xref: MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047852
name: diferric-transferrin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: transferrin[Fe2+]2 + NAD+ = transferrin[Fe3+]2 + NADH." [EC:1.16.1.2, MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN]
synonym: "diferric transferrin reductase activity" EXACT [EC:1.16.1.2]
synonym: "NADH diferric transferrin reductase activity" EXACT [EC:1.16.1.2]
synonym: "transferrin reductase activity" EXACT [EC:1.16.1.2]
synonym: "transferrin[Fe(II)]2:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.2]
xref: EC:1.16.1.2
xref: MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0047853
name: difructose-anhydride synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose." [EC:3.2.1.134, MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN]
synonym: "bis-D-fructose 2',1:2,1'-dianhydride fructohydrolase activity" EXACT [EC:3.2.1.134]
synonym: "inulobiose hydrolase activity" EXACT [EC:3.2.1.134]
xref: EC:3.2.1.134
xref: MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047854
name: diguanidinobutanase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-diguanidinobutane + H2O = agmatine + urea." [EC:3.5.3.20, MetaCyc:DIGUANIDINOBUTANASE-RXN]
synonym: "1,4-diguanidinobutane amidinohydrolase activity" EXACT [EC:3.5.3.20]
xref: EC:3.5.3.20
xref: MetaCyc:DIGUANIDINOBUTANASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047855
name: dihydrobunolol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol + NADP+ = (+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone + NADPH." [EC:1.1.1.160, MetaCyc:DIHYDROBUNOLOL-DEHYDROGENASE-RXN]
synonym: "(+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.160]
synonym: "bunolol reductase activity" EXACT [EC:1.1.1.160]
xref: EC:1.1.1.160
xref: MetaCyc:DIHYDROBUNOLOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047856
name: dihydrocoumarin hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrocoumarin + H2O = melilotate." [EC:3.1.1.35, MetaCyc:DIHYDROCOUMARIN-LIPASE-RXN]
subset: gosubset_prok
synonym: "dihydrocoumarin lactonohydrolase activity" EXACT [EC:3.1.1.35]
synonym: "dihydrocoumarin lipase activity" EXACT []
xref: EC:3.1.1.35
xref: MetaCyc:DIHYDROCOUMARIN-LIPASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047857
name: dihydrouracil oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,6-dihydrouracil + O2 = uracil + H2O2." [EC:1.3.3.7, MetaCyc:DIHYDROURACIL-OXIDASE-RXN]
synonym: "5,6-dihydrouracil:oxygen oxidoreductase activity" EXACT [EC:1.3.3.7]
xref: EC:1.3.3.7
xref: MetaCyc:DIHYDROURACIL-OXIDASE-RXN
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0047858
name: dihydroxyfumarate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydroxyfumarate = tartronate semialdehyde + CO2." [EC:4.1.1.54, MetaCyc:DIHYDROXYFUMARATE-DECARBOXYLASE-RXN]
synonym: "dihydroxyfumarate carboxy-lyase (tartronate-semialdehyde-forming)" EXACT [EC:4.1.1.54]
synonym: "dihydroxyfumarate carboxy-lyase activity" EXACT [EC:4.1.1.54]
xref: EC:4.1.1.54
xref: MetaCyc:DIHYDROXYFUMARATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047859
name: dihydroxyphenylalanine ammonia-lyase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine = trans-caffeate + NH3." [EC:4.3.1.11, MetaCyc:DIHYDROXYPHENYLALANINE-AMMONIA-LYASE-RXN]
comment: This term was made obsolete because the corresponding EC reaction has been deleted from the EC.
synonym: "3,4-dihydroxy-L-phenylalanine ammonia-lyase (trans-caffeate-forming)" EXACT [EC:4.3.1.11]
synonym: "3,4-dihydroxy-L-phenylalanine ammonia-lyase activity" EXACT [EC:4.3.1.11]
synonym: "beta-(3,4-dihydroxyphenyl)-L-alanine (DOPA) ammonia-lyase activity" EXACT [EC:4.3.1.11]
xref: EC:4.3.1.11
is_obsolete: true

[Term]
id: GO:0047860
name: diiodophenylpyruvate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH." [EC:1.1.1.96, MetaCyc:DIIODOPHENYLPYRUVATE-REDUCTASE-RXN]
synonym: "2-oxo acid reductase activity" EXACT [EC:1.1.1.96]
synonym: "3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.96]
synonym: "aromatic alpha-keto acid" RELATED [EC:1.1.1.96]
synonym: "KAR" RELATED [EC:1.1.1.96]
xref: EC:1.1.1.96
xref: MetaCyc:DIIODOPHENYLPYRUVATE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047861
name: diiodotyrosine transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,5-diiodo-L-tyrosine + 2-oxoglutarate = 3,5-diiodo-4-hydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.24, MetaCyc:DIIODOTYROSINE-AMINOTRANSFERASE-RXN]
synonym: "3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.24]
synonym: "diiodotyrosine aminotransferase activity" EXACT []
synonym: "halogenated tyrosine aminotransferase activity" EXACT [EC:2.6.1.24]
synonym: "halogenated tyrosine transaminase activity" EXACT [EC:2.6.1.24]
xref: EC:2.6.1.24
xref: MetaCyc:DIIODOTYROSINE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047862
name: diisopropyl-fluorophosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride." [EC:3.1.8.2, MetaCyc:DIISOPROPYL-FLUOROPHOSPHATASE-RXN]
synonym: "DFPase activity" EXACT [EC:3.1.8.2]
synonym: "dialkylfluorophosphatase activity" EXACT [EC:3.1.8.2]
synonym: "diisopropyl phosphorofluoridate hydrolase activity" EXACT [EC:3.1.8.2]
synonym: "diisopropyl-fluorophosphate fluorohydrolase activity" EXACT [EC:3.1.8.2]
synonym: "diisopropylfluorophosphonate dehalogenase activity" EXACT [EC:3.1.8.2]
synonym: "diisopropylphosphofluoridase activity" EXACT [EC:3.1.8.2]
synonym: "isopropylphosphorofluoridase activity" EXACT [EC:3.1.8.2]
synonym: "OPA anhydrase activity" EXACT [EC:3.1.8.2]
synonym: "OPAA activity" EXACT [EC:3.1.8.2]
synonym: "organophosphate acid anhydrase activity" EXACT [EC:3.1.8.2]
synonym: "organophosphorus acid anhydrolase activity" EXACT [EC:3.1.8.2]
synonym: "somanase activity" EXACT [EC:3.1.8.2]
synonym: "tabunase activity" EXACT [EC:3.1.8.2]
xref: EC:3.1.8.2
xref: MetaCyc:DIISOPROPYL-FLUOROPHOSPHATASE-RXN
is_a: GO:0016795 ! phosphoric triester hydrolase activity

[Term]
id: GO:0047863
name: dimethylallylcistransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate." [EC:2.5.1.28, MetaCyc:DIMETHYLALLYLCISTRANSFERASE-RXN]
synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallylcistransferase activity" EXACT [EC:2.5.1.28]
synonym: "neryl-diphosphate synthase activity" EXACT [EC:2.5.1.28]
xref: EC:2.5.1.28
xref: MetaCyc:DIMETHYLALLYLCISTRANSFERASE-RXN
is_a: GO:0004659 ! prenyltransferase activity

[Term]
id: GO:0047864
name: dimethylaniline-N-oxide aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde." [EC:4.1.2.24, MetaCyc:DIMETHYLANILINE-N-OXIDE-ALDOLASE-RXN]
subset: gosubset_prok
synonym: "microsomal N-oxide dealkylase activity" EXACT [EC:4.1.2.24]
synonym: "microsomal oxidase II" RELATED [EC:4.1.2.24]
synonym: "N,N-dimethylaniline-N-oxide formaldehyde-lyase (N-methylaniline-forming)" EXACT [EC:4.1.2.24]
synonym: "N,N-dimethylaniline-N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.24]
xref: EC:4.1.2.24
xref: MetaCyc:DIMETHYLANILINE-N-OXIDE-ALDOLASE-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047865
name: dimethylglycine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N-dimethylglycine + acceptor + H2O = sarcosine + formaldehyde + reduced acceptor." [EC:1.5.99.2, MetaCyc:DIMETHYLGLYCINE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "N,N-dimethylglycine oxidase activity" EXACT [EC:1.5.99.2]
synonym: "N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.99.2]
synonym: "N,N-dimethylglycine:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.99.2]
xref: EC:1.5.99.2
xref: MetaCyc:DIMETHYLGLYCINE-DEHYDROGENASE-RXN
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0047866
name: dimethylglycine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N-dimethylglycine + H2O + O2 = sarcosine + formaldehyde + H2O2." [EC:1.5.3.10, MetaCyc:DIMETHYLGLYCINE-OXIDASE-RXN]
synonym: "N,N-dimethylglycine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.10]
xref: EC:1.5.3.10
xref: MetaCyc:DIMETHYLGLYCINE-OXIDASE-RXN
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0047867
name: dimethylmalate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH." [EC:1.1.1.84, MetaCyc:DIMETHYLMALATE-DEHYDROGENASE-RXN]
synonym: "(R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.84]
synonym: "beta,beta-dimethylmalate dehydrogenase activity" EXACT [EC:1.1.1.84]
xref: EC:1.1.1.84
xref: MetaCyc:DIMETHYLMALATE-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047868
name: dimethylmaleate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O." [EC:4.2.1.85, MetaCyc:DIMETHYLMALEATE-HYDRATASE-RXN]
synonym: "(2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming)" EXACT [EC:4.2.1.85]
synonym: "(2R,3S)-2,3-dimethylmalate hydro-lyase activity" EXACT [EC:4.2.1.85]
xref: EC:4.2.1.85
xref: MetaCyc:DIMETHYLMALEATE-HYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047869
name: dimethylpropiothetin dethiomethylase activity
namespace: molecular_function
def: "Catalysis of the reaction: S,S-dimethyl-beta-propiothetin = dimethyl sulfide + acrylate." [EC:4.4.1.3, MetaCyc:DIMETHYLPROPIOTHETIN-DETHIOMETHYLASE-RXN]
synonym: "desulfhydrase activity" EXACT [EC:4.4.1.3]
synonym: "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase (acrylate-forming)" EXACT [EC:4.4.1.3]
synonym: "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase activity" EXACT [EC:4.4.1.3]
xref: EC:4.4.1.3
xref: MetaCyc:DIMETHYLPROPIOTHETIN-DETHIOMETHYLASE-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0047870
name: discadenine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + N6-(D2-isopentenyl)-adenine = 5'-methylthioadenosine + discadenine." [EC:2.5.1.24, MetaCyc:DISCADENINE-SYNTHASE-RXN]
synonym: "discadenine synthetase activity" EXACT [EC:2.5.1.24]
synonym: "S-adenosyl-L-methionine:6-N-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferase activity" EXACT [EC:2.5.1.24]
synonym: "S-adenosyl-L-methionine:N6-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferas" RELATED [EC:2.5.1.24]
xref: EC:2.5.1.24
xref: MetaCyc:DISCADENINE-SYNTHASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0047871
name: disulfoglucosamine-6-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,6-O-disulfo-D-glucosamine + H2O = N-sulfo-D-glucosamine + SO4(2-) (sulfate)." [EC:3.1.6.11, MetaCyc:DISULFOGLUCOSAMINE-6-SULFATASE-RXN]
synonym: "6,N-disulfoglucosamine 6-O-sulfohydrolase activity" EXACT [EC:3.1.6.11]
synonym: "disulphoglucosamine-6-sulphatase activity" EXACT []
synonym: "N,6-O-disulfo-D-glucosamine 6-sulfohydrolase activity" EXACT [EC:3.1.6.11]
synonym: "N-sulfoglucosamine-6-sulfatase activity" EXACT [EC:3.1.6.11]
xref: EC:3.1.6.11
xref: MetaCyc:DISULFOGLUCOSAMINE-6-SULFATASE-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0047872
name: dolichol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + dolichol = CoA + dolichyl palmitate." [EC:2.3.1.123, MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN]
synonym: "acyl-CoA:dolichol acyltransferase activity" EXACT [EC:2.3.1.123]
synonym: "palmitoyl-CoA:dolichol O-palmitoyltransferase activity" EXACT [EC:2.3.1.123]
xref: EC:2.3.1.123
xref: MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047873
name: dolichyl-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate." [EC:3.1.3.51, MetaCyc:DOLICHYL-PHOSPHATASE-RXN]
synonym: "Dol-P phosphatase activity" EXACT [EC:3.1.3.51]
synonym: "Dol-P-P phosphohydrolase activity" EXACT []
synonym: "dolichol monophosphatase activity" EXACT [EC:3.1.3.51]
synonym: "dolichol phosphatase activity" EXACT [EC:3.1.3.51]
synonym: "dolichol phosphate phosphatase activity" EXACT [EC:3.1.3.51]
synonym: "dolichyl monophosphate phosphatase activity" EXACT [EC:3.1.3.51]
synonym: "dolichyl phosphate phosphatase activity" EXACT [EC:3.1.3.51]
synonym: "dolichyl pyrophosphate phosphatase activity" EXACT []
synonym: "dolichyl-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.51]
synonym: "polyisoprenyl phosphate phosphatase activity" EXACT [EC:3.1.3.51]
synonym: "polyprenylphosphate phosphatase activity" EXACT [EC:3.1.3.51]
xref: EC:3.1.3.51
xref: MetaCyc:DOLICHYL-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047874
name: dolichyldiphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate." [EC:3.6.1.43, MetaCyc:DOLICHYLDIPHOSPHATASE-RXN]
synonym: "dolichol diphosphatase activity" EXACT [EC:3.6.1.43]
synonym: "dolichyl diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.43]
synonym: "dolichyl pyrophosphatase activity" EXACT [EC:3.6.1.43]
synonym: "dolichyl-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.43]
xref: EC:3.6.1.43
xref: MetaCyc:DOLICHYLDIPHOSPHATASE-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0047875
name: ecdysone oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: ecdysone + O2 = 3-dehydroecdysone + H2O2." [EC:1.1.3.16, MetaCyc:ECDYSONE-OXIDASE-RXN]
synonym: "beta-ecdysone oxidase activity" EXACT [EC:1.1.3.16]
synonym: "ecdysone:oxygen 3-oxidoreductase activity" EXACT [EC:1.1.3.16]
xref: EC:1.1.3.16
xref: MetaCyc:ECDYSONE-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047876
name: endoglycosylceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose." [EC:3.2.1.123, MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN]
subset: gosubset_prok
synonym: "EGCase activity" EXACT [EC:3.2.1.123]
synonym: "endo-glucosylceramidase activity" EXACT [EC:3.2.1.123]
synonym: "endoglycoceramidase activity" EXACT [EC:3.2.1.123]
synonym: "glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase activity" EXACT [EC:3.2.1.123]
synonym: "oligoglycosylglucosylceramide glycohydrolase activity" EXACT [EC:3.2.1.123]
xref: EC:3.2.1.123
xref: MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047877
name: ephedrine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-ephedrine + NAD+ = (R)-2-methylimino-1-phenylpropan-1-ol + NADH." [EC:1.5.1.18, MetaCyc:EPHEDRINE-DEHYDROGENASE-RXN]
synonym: "(-)-ephedrine:NAD+ 2-oxidoreductase activity" EXACT [EC:1.5.1.18]
xref: EC:1.5.1.18
xref: MetaCyc:EPHEDRINE-DEHYDROGENASE-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047878
name: erythritol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + erythritol = ADP + D-erythritol 4-phosphate." [EC:2.7.1.27, MetaCyc:ERYTHRITOL-KINASE-RXN]
subset: gosubset_prok
synonym: "ATP:erythritol 4-phosphotransferase activity" EXACT [EC:2.7.1.27]
synonym: "erythritol kinase (phosphorylating)" EXACT [EC:2.7.1.27]
xref: EC:2.7.1.27
xref: MetaCyc:ERYTHRITOL-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047879
name: erythronolide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 6 malonyl-CoA + propionyl-CoA = 7 CoA + 6-deoxyerythronolide B." [EC:2.3.1.94, MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN]
subset: gosubset_prok
synonym: "erythronolide condensing enzyme activity" EXACT [EC:2.3.1.94]
synonym: "malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.94]
xref: EC:2.3.1.94
xref: MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047880
name: erythrulose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: erythritol + NADP+ = D-erythrulose + NADPH." [EC:1.1.1.162, MetaCyc:ERYTHRULOSE-REDUCTASE-RXN]
synonym: "D-erythrulose reductase activity" EXACT [EC:1.1.1.162]
synonym: "erythritol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.162]
xref: EC:1.1.1.162
xref: MetaCyc:ERYTHRULOSE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047881
name: estradiol 17-alpha-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+." [EC:1.1.1.148, MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN]
synonym: "17alpha-estradiol dehydrogenase activity" EXACT [EC:1.1.1.148]
synonym: "17alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.148]
synonym: "17alpha-hydroxy steroid oxidoreductase activity" EXACT [EC:1.1.1.148]
synonym: "17alpha-hydroxysteroid oxidoreductase activity" EXACT [EC:1.1.1.148]
synonym: "17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase activity" EXACT [EC:1.1.1.148]
synonym: "estradiol 17a-dehydrogenase activity" EXACT []
synonym: "estradiol 17alpha-dehydrogenase activity" EXACT [EC:1.1.1.148]
synonym: "estradiol 17alpha-oxidoreductase activity" EXACT [EC:1.1.1.148]
xref: EC:1.1.1.148
xref: MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047882
name: estradiol 6-beta-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: estradiol-17-beta + donor-H2 + O2 = 6-beta-hydroxyestradiol-17-beta + acceptor + H2O." [EC:1.14.99.11, MetaCyc:ESTRADIOL-6-BETA-MONOOXYGENASE-RXN]
synonym: "estradiol 6-beta-hydroxylase activity" EXACT [EC:1.14.99.11]
synonym: "estradiol 6b-hydroxylase activity" EXACT []
synonym: "estradiol 6b-monooxygenase activity" EXACT []
synonym: "estradiol 6beta-hydroxylase activity" EXACT [EC:1.14.99.11]
synonym: "estradiol 6beta-monooxygenase activity" EXACT [EC:1.14.99.11]
synonym: "estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating)" EXACT [EC:1.14.99.11]
xref: EC:1.14.99.11
xref: MetaCyc:ESTRADIOL-6-BETA-MONOOXYGENASE-RXN
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0047883
name: ethanolamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2." [EC:1.4.3.8, MetaCyc:ETHANOLAMINE-OXIDASE-RXN]
synonym: "ethanolamine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.8]
xref: EC:1.4.3.8
xref: MetaCyc:ETHANOLAMINE-OXIDASE-RXN
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0047884
name: FAD diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: FAD + H2O = AMP + FMN." [EC:3.6.1.18, MetaCyc:FAD-PYROPHOSPHATASE-RXN]
synonym: "FAD nucleotidohydrolase activity" EXACT [EC:3.6.1.18]
synonym: "FAD pyrophosphatase activity" EXACT []
synonym: "FAD pyrophosphohydrolase activity" EXACT [GOC:tb]
synonym: "flavin adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18]
synonym: "flavine adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18]
synonym: "riboflavin adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18]
synonym: "riboflavine adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.18]
xref: EC:3.6.1.18
xref: MetaCyc:FAD-PYROPHOSPHATASE-RXN
is_a: GO:0004551 ! nucleotide diphosphatase activity

[Term]
id: GO:0047885
name: farnesol 2-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol." [EC:5.2.1.9, MetaCyc:FARNESOL-2-ISOMERASE-RXN]
subset: gosubset_prok
synonym: "2-trans,6-trans-farnesol 2-cis-trans-isomerase activity" EXACT [EC:5.2.1.9]
synonym: "farnesol isomerase activity" EXACT [EC:5.2.1.9]
xref: EC:5.2.1.9
xref: MetaCyc:FARNESOL-2-ISOMERASE-RXN
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0047886
name: farnesol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP+ = 2-trans,6-trans-farnesal + NADPH." [EC:1.1.1.216, MetaCyc:FARNESOL-DEHYDROGENASE-RXN]
synonym: "2-trans,6-trans-farnesol:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.216]
synonym: "farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.216]
synonym: "NADP-farnesol dehydrogenase activity" EXACT [EC:1.1.1.216]
xref: EC:1.1.1.216
xref: MetaCyc:FARNESOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047887
name: farnesyl diphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + farnesyl diphosphate = ADP + farnesyl triphosphate." [EC:2.7.4.18, MetaCyc:FARNESYL-DIPHOSPHATE-KINASE-RXN]
synonym: "ATP:farnesyl-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.18]
synonym: "farnesyl pyrophosphate kinase activity" EXACT [EC:2.7.4.18]
synonym: "farnesyl-diphosphate kinase activity" EXACT []
xref: EC:2.7.4.18
xref: MetaCyc:FARNESYL-DIPHOSPHATE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0047888
name: fatty-acid peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitate + 2 H2O2 = pentadecanal + CO2 + 3 H2O." [EC:1.11.1.3, MetaCyc:FATTY-ACID-PEROXIDASE-RXN]
synonym: "fatty acid peroxidase activity" EXACT []
synonym: "hexadecanoate:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.3]
synonym: "long chain fatty acid peroxidase activity" EXACT [EC:1.11.1.3]
xref: EC:1.11.1.3
xref: MetaCyc:FATTY-ACID-PEROXIDASE-RXN
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0047889
name: ferredoxin-nitrate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NO2- (nitrite) + H2O + 2 oxidized ferredoxin = NO3- (nitrate) + 2 reduced ferredoxin." [EC:1.7.7.2, MetaCyc:FERREDOXIN--NITRATE-REDUCTASE-RXN]
synonym: "assimilatory ferredoxin-nitrate reductase activity" EXACT [EC:1.7.7.2]
synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.7.2]
synonym: "nitrate (ferredoxin) reductase activity" EXACT [EC:1.7.7.2]
synonym: "nitrite:ferredoxin oxidoreductase activity" EXACT [EC:1.7.7.2]
xref: EC:1.7.7.2
xref: MetaCyc:1.7.7.2-RXN
is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor

[Term]
id: GO:0047890
name: flavanone 4-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH." [EC:1.1.1.234, MetaCyc:FLAVANONE-4-REDUCTASE-RXN]
synonym: "(2S)-flavan-4-ol:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.234]
synonym: "flavonone 4-reductase activity" EXACT []
xref: EC:1.1.1.234
xref: MetaCyc:FLAVANONE-4-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047891
name: flavone 7-O-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone." [EC:2.4.1.81, MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "flavone 7-O-b-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-apigenin beta-glucosyltransferase activity" EXACT [EC:2.4.1.81]
synonym: "UDP-glucose-luteolin beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81]
synonym: "UDP-glucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81]
synonym: "UDPglucose-apigenin beta-glucosyltransferase activity" EXACT [EC:2.4.1.81]
synonym: "UDPglucose-luteolin beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81]
synonym: "UDPglucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.81]
synonym: "uridine diphosphoglucose-apigenin 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.81]
synonym: "uridine diphosphoglucose-luteolin glucosyltransferase activity" EXACT [EC:2.4.1.81]
xref: EC:2.4.1.81
xref: MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047892
name: flavone apiosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone." [EC:2.4.2.25, MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN]
synonym: "UDP-apiose:5,4'-dihydroxyflavone 7-O-beta-D-glucoside 2''-O-beta-D-apiofuranosyltransferase activity" EXACT [EC:2.4.2.25]
synonym: "UDP-apiose:7-O-(beta-D-glucosyl)-flavone apiosyltransferase activity" EXACT [EC:2.4.2.25]
synonym: "uridine diphosphoapiose-flavone apiosyltransferase activity" EXACT [EC:2.4.2.25]
xref: EC:2.4.2.25
xref: MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0047893
name: flavonol 3-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside." [EC:2.4.1.91, MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN]
synonym: "GTI" RELATED [EC:2.4.1.91]
synonym: "UDP-glucose flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91]
synonym: "UDP-glucose:flavonol 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.91]
synonym: "UDP-glucose:flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91]
synonym: "UDPG:flavonoid-3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91]
synonym: "UDPglucose:flavonol 3-O-D-glucosyltransferase activity" EXACT [EC:2.4.1.91]
synonym: "uridine diphosphoglucose-flavonol 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.91]
xref: EC:2.4.1.91
xref: MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047894
name: flavonol 3-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + quercetin = adenosine 3',5'-bisphosphate + quercetin 3-sulfate." [EC:2.8.2.25, MetaCyc:FLAVONOL-3-SULFOTRANSFERASE-RXN]
synonym: "3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase activity" EXACT [EC:2.8.2.25]
synonym: "flavonol 3-sulphotransferase activity" EXACT []
xref: EC:2.8.2.25
xref: MetaCyc:FLAVONOL-3-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0047895
name: formaldehyde dismutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate." [EC:1.2.99.4, MetaCyc:FORMALDEHYDE-DISMUTASE-RXN]
synonym: "aldehyde dismutase activity" EXACT [EC:1.2.99.4]
synonym: "cannizzanase activity" EXACT [EC:1.2.99.4]
synonym: "formaldehyde:formaldehyde oxidoreductase activity" EXACT [EC:1.2.99.4]
xref: EC:1.2.99.4
xref: MetaCyc:FORMALDEHYDE-DISMUTASE-RXN
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0047896
name: formaldehyde transketolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + glycerone." [EC:2.2.1.3, MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN]
synonym: "D-xylulose-5-phosphate:formaldehyde glycolaldehydetransferase activity" EXACT [EC:2.2.1.3]
synonym: "DHAS activity" EXACT [EC:2.2.1.3]
synonym: "dihydroxyacetone synthase activity" EXACT [EC:2.2.1.3]
synonym: "glycerone synthase activity" EXACT [EC:2.2.1.3]
xref: EC:2.2.1.3
xref: MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0047897
name: formate-dihydrofolate ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + formate + dihydrofolate = ADP + phosphate + 10-formyldihydrofolate." [EC:6.3.4.17, MetaCyc:FORMATE--DIHYDROFOLATE-LIGASE-RXN]
synonym: "dihydrofolate formyltransferase activity" EXACT [EC:6.3.4.17]
synonym: "formate:dihydrofolate ligase (ADP-forming)" EXACT [EC:6.3.4.17]
synonym: "formyl dihydrofolate synthase activity" EXACT [EC:6.3.4.17]
xref: EC:6.3.4.17
xref: MetaCyc:FORMATE--DIHYDROFOLATE-LIGASE-RXN
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0047898
name: formate dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: formate + ferricytochrome b1 = CO2 + ferrocytochrome b1." [EC:1.2.2.1, MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN]
synonym: "formate:cytochrome b1 oxidoreductase activity" EXACT [EC:1.2.2.1]
synonym: "formate:ferricytochrome-b1 oxidoreductase activity" EXACT [EC:1.2.2.1]
xref: EC:1.2.2.1
xref: MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN
is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor

[Term]
id: GO:0047899
name: formate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: formate + NADP+ = CO2 + NADPH." [EC:1.2.1.43, MetaCyc:FORMATE-DEHYDROGENASE-NADP+-RXN]
subset: gosubset_prok
synonym: "formate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.43]
synonym: "NADP-dependent formate dehydrogenase activity" EXACT [EC:1.2.1.43]
xref: EC:1.2.1.43
xref: MetaCyc:FORMATE-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047900
name: formate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + formate = ADP + formyl phosphate." [EC:2.7.2.6, MetaCyc:FORMATE-KINASE-RXN]
synonym: "ATP:formate phosphotransferase activity" EXACT [EC:2.7.2.6]
xref: EC:2.7.2.6
xref: MetaCyc:FORMATE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0047901
name: formyl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: formyl-CoA + H2O = CoA + formate." [EC:3.1.2.10, MetaCyc:FORMYL-COA-HYDROLASE-RXN]
synonym: "formyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.10]
xref: EC:3.1.2.10
xref: MetaCyc:FORMYL-COA-HYDROLASE-RXN
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0047902
name: formylaspartate deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate." [EC:3.5.1.8, MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN]
synonym: "formylaspartic formylase (formylase I, formylase II)" EXACT [EC:3.5.1.8]
synonym: "N-formyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.8]
xref: EC:3.5.1.8
xref: MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047903
name: fructose 5-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH." [EC:1.1.1.124, MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN]
subset: gosubset_prok
synonym: "5-keto-D-fructose reductase (NADP+)" EXACT [EC:1.1.1.124]
synonym: "5-ketofructose reductase (NADP(+)) activity" EXACT [EC:1.1.1.124]
synonym: "5-ketofructose reductase (NADP)" EXACT [EC:1.1.1.124]
synonym: "5-ketofructose reductase (NADP+) activity" EXACT [EC:1.1.1.124]
synonym: "D-(-)fructose:(NADP+) 5-oxidoreductase activity" EXACT [EC:1.1.1.124]
synonym: "D-fructose:NADP+ 5-oxidoreductase activity" EXACT [EC:1.1.1.124]
synonym: "fructose 5-(nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.124]
xref: EC:1.1.1.124
xref: MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047904
name: fructose 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose + acceptor = 5-dehydro-D-fructose + reduced acceptor." [EC:1.1.99.11, MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN]
synonym: "D-fructose dehydrogenase activity" EXACT [EC:1.1.99.11]
synonym: "D-fructose:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.11]
synonym: "D-fructose:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.11]
synonym: "fructose 5-dehydrogenase (acceptor)" EXACT [EC:1.1.99.11]
xref: EC:1.1.99.11
xref: MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047905
name: fructose-6-phosphate phosphoketolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O." [EC:4.1.2.22, MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN]
subset: gosubset_prok
synonym: "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)" EXACT [EC:4.1.2.22]
synonym: "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (phosphate-acetylating) activity" EXACT [EC:4.1.2.22]
xref: EC:4.1.2.22
xref: MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047906
name: fucosterol-epoxide lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = desmosterol + acetaldehyde." [EC:4.1.2.33, MetaCyc:FUCOSTEROL-EPOXIDE-LYASE-RXN]
synonym: "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming)" EXACT [EC:4.1.2.33]
synonym: "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase activity" EXACT [EC:4.1.2.33]
xref: EC:4.1.2.33
xref: MetaCyc:FUCOSTEROL-EPOXIDE-LYASE-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0047907
name: furylfuramide isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide." [EC:5.2.1.6, MetaCyc:FURYLFURAMIDE-ISOMERASE-RXN]
synonym: "2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase activity" EXACT [EC:5.2.1.6]
xref: EC:5.2.1.6
xref: MetaCyc:FURYLFURAMIDE-ISOMERASE-RXN
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0047908
name: fusarinine-C ornithinesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol." [EC:3.1.1.48, MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN]
synonym: "5-N-acyl-L-ornithine-ester hydrolase activity" EXACT [EC:3.1.1.48]
synonym: "N5-acyl-L-ornithine-ester hydrolase activity" EXACT [EC:3.1.1.48]
synonym: "ornithine esterase activity" EXACT [EC:3.1.1.48]
xref: EC:3.1.1.48
xref: MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047909
name: galactolipid O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyl-diacylglycerol + mono-beta-D-galactosylacylglycerol." [EC:2.3.1.134, MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN]
synonym: "galactolipid:galactolipid acyltransferase activity" EXACT [EC:2.3.1.134]
synonym: "mono-beta-D-galactosyldiacylglycerol:mono-beta-D-galactosyldiacylglycerol acyltransferase activity" EXACT [EC:2.3.1.134]
xref: EC:2.3.1.134
xref: MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0047910
name: galactose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose + NADP+ = D-galactonolactone + NADPH." [EC:1.1.1.120, MetaCyc:GALACTOSE-1-DEHYDROGENASE-NADP+-RXN]
synonym: "D-galactose dehydrogenase (NADP+)" EXACT [EC:1.1.1.120]
synonym: "D-galactose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.120]
xref: EC:1.1.1.120
xref: MetaCyc:GALACTOSE-1-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047911
name: galacturan 1,4-alpha-galacturonidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-alpha-D-galacturonide(n) + H2O = 1,4-alpha-D-galacturonide(n-1) + D-galacturonate." [EC:3.2.1.67, MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN]
synonym: "exo-D-galacturonanase activity" EXACT [EC:3.2.1.67]
synonym: "exo-D-galacturonase activity" EXACT []
synonym: "exo-polygalacturonase activity" EXACT []
synonym: "exopoly-D-galacturonase activity" EXACT []
synonym: "exopolygalacturonase activity" EXACT [EC:3.2.1.67]
synonym: "galacturan 1,4-a-galacturonidase activity" EXACT []
synonym: "poly(1,4-alpha-D-galacturonide) galacturonohydrolase activity" EXACT [EC:3.2.1.67]
synonym: "poly(galacturonate) hydrolase activity" EXACT [EC:3.2.1.67]
xref: EC:3.2.1.67
xref: MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047912
name: galacturonokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-galacturonate = ADP + 1-phospho-alpha-D-galacturonate." [EC:2.7.1.44, MetaCyc:GALACTURONOKINASE-RXN]
synonym: "ATP:D-galacturonate 1-phosphotransferase activity" EXACT [EC:2.7.1.44]
synonym: "galacturonokinase (phosphorylating) D-galacturonic acid kinase activity" EXACT [EC:2.7.1.44]
xref: EC:2.7.1.44
xref: MetaCyc:GALACTURONOKINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047913
name: gallate 1-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + gallate = UDP + 1-galloyl-beta-D-glucose." [EC:2.4.1.136, MetaCyc:GALLATE-1-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "gallate 1-b-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose-vanillate 1-glucosyltransferase activity" EXACT [EC:2.4.1.136]
synonym: "UDP-glucose:gallate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.136]
synonym: "UDPglucose-vanillate 1-glucosyltransferase activity" EXACT [EC:2.4.1.136]
synonym: "UDPglucose:gallate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.136]
synonym: "UDPglucose:gallate glucosyltransferase activity" EXACT [EC:2.4.1.136]
synonym: "UDPglucose:vanillate 1-O-glucosyltransferase activity" EXACT [EC:2.4.1.136]
xref: EC:2.4.1.136
xref: MetaCyc:GALLATE-1-BETA-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047914
name: gamma-glutamylhistamine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown." [EC:6.3.2.18, MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN]
synonym: "g-glutamylhistamine synthase activity" EXACT []
synonym: "gamma-GHA synthetase activity" EXACT [EC:6.3.2.18]
synonym: "gamma-glutaminylhistamine synthetase activity" EXACT [EC:6.3.2.18]
synonym: "L-glutamate:histamine ligase activity" EXACT [EC:6.3.2.18]
xref: EC:6.3.2.18
xref: MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047915
name: ganglioside galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine." [EC:2.4.1.62, MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN]
synonym: "GM1-synthase activity" EXACT [EC:2.4.1.62]
synonym: "UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "UDP-galactose-GM2 galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "UDP-galactose-GM2 ganglioside galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "UDPgalactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "UDPgalactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "uridine diphosphate D-galactose:glycolipid galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "uridine diphosphogalactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.62]
synonym: "uridine diphosphogalactose-GM2 galactosyltransferase activity" EXACT [EC:2.4.1.62]
xref: EC:2.4.1.62
xref: MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0047916
name: GDP-6-deoxy-D-talose 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-6-deoxy-D-talose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H + H+." [EC:1.1.1.135, MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN]
synonym: "GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase activity" EXACT [EC:1.1.1.135]
synonym: "guanosine diphospho-6-deoxy-D-talose dehydrogenase activity" EXACT [EC:1.1.1.135]
xref: EC:1.1.1.135
xref: MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047917
name: GDP-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-glucose + H2O = D-glucose + GDP." [EC:3.2.1.42, MetaCyc:GDP-GLUCOSIDASE-RXN]
synonym: "GDP-glucose glucohydrolase activity" EXACT [EC:3.2.1.42]
synonym: "GDPglucose glucohydrolase activity" EXACT [EC:3.2.1.42]
synonym: "GDPglucosidase activity" EXACT [EC:3.2.1.42]
synonym: "guanosine diphosphate D-glucose glucohydrolase activity" EXACT [EC:3.2.1.42]
synonym: "guanosine diphosphoglucosidase activity" EXACT [EC:3.2.1.42]
xref: EC:3.2.1.42
xref: MetaCyc:GDP-GLUCOSIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047918
name: GDP-mannose 3,5-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose = GDP-L-galactose." [EC:5.1.3.18]
synonym: "GDP-D-mannose:GDP-L-galactose epimerase activity" EXACT [EC:5.1.3.18]
synonym: "GDPmannose 3,5-epimerase activity" EXACT [EC:5.1.3.18]
synonym: "guanosine 5'-diphosphate D-mannose:guanosine 5'-diphosphate L-galactose epimerase activity" EXACT [EC:5.1.3.18]
xref: EC:5.1.3.18
xref: MetaCyc:RXN-1882
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047919
name: GDP-mannose 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH." [EC:1.1.1.132, MetaCyc:GDP-MANNOSE-6-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "GDP mannose dehydrogenase activity" EXACT [EC:1.1.1.132]
synonym: "GDP-D-mannose:NAD+ 6-oxidoreductase activity" EXACT [EC:1.1.1.132]
synonym: "GDPmannose 6-dehydrogenase activity" EXACT [EC:1.1.1.132]
synonym: "guanosine diphospho-D-mannose dehydrogenase activity" EXACT [EC:1.1.1.132]
synonym: "guanosine diphosphomannose dehydrogenase activity" EXACT [EC:1.1.1.132]
xref: EC:1.1.1.132
xref: MetaCyc:GDP-MANNOSE-6-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047920
name: geissoschizine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: geissoschizine + NADP+ = 4,21-dehydrogeissoschizine + NADPH." [EC:1.3.1.36, MetaCyc:GEISSOSCHIZINE-DEHYDROGENASE-RXN]
synonym: "geissoschizine:NADP+ 4,21-oxidoreductase activity" EXACT [EC:1.3.1.36]
xref: EC:1.3.1.36
xref: MetaCyc:GEISSOSCHIZINE-DEHYDROGENASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047921
name: aminoglycoside 2'-N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 2'-N-acetylaminoglycoside. This is acetylation of the 2'-amino group of the 6-deoxy-6-aminoglucose ring." [GOC:cb]
synonym: "acetyl-CoA:gentamicin-C1a N2'-acetyltransferase activity" NARROW [EC:2.3.1.59]
synonym: "acetyl-CoA:gentamycin-C1a N2'-acetyltransferase activity" NARROW [EC:2.3.1.59]
synonym: "gentamicin 2'-N-acetyltransferase activity" NARROW []
synonym: "gentamicin acetyltransferase II activity" NARROW [EC:2.3.1.59]
synonym: "gentamycin 2'-N-acetyltransferase activity" NARROW []
synonym: "gentamycin acetyltransferase II" RELATED [EC:2.3.1.59]
xref: EC:2.3.1.59
xref: MetaCyc:GENTAMICIN-2-N-ACETYLTRANSFERASE-RXN
is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity

[Term]
id: GO:0047922
name: gentisate 1,2-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dihydroxybenzoate + O2 = maleylpyruvate." [EC:1.13.11.4, MetaCyc:GENTISATE-12-DIOXYGENASE-RXN]
subset: gosubset_prok
synonym: "2,5-dihydroxybenzoate dioxygenase activity" EXACT [EC:1.13.11.4]
synonym: "gentisate dioxygenase activity" EXACT [EC:1.13.11.4]
synonym: "gentisate oxygenase activity" EXACT [EC:1.13.11.4]
synonym: "gentisate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.4]
synonym: "gentisic acid oxidase activity" EXACT [EC:1.13.11.4]
xref: EC:1.13.11.4
xref: MetaCyc:GENTISATE-12-DIOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0047923
name: gentisate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,5-dihydroxybenzoate = hydroquinone + CO2." [EC:4.1.1.62, MetaCyc:GENTISATE-DECARBOXYLASE-RXN]
synonym: "2,5-dihydroxybenzoate carboxy-lyase (hydroquinone-forming)" EXACT [EC:4.1.1.62]
synonym: "2,5-dihydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.62]
synonym: "gentisate carboxy-lyase activity" EXACT [EC:4.1.1.62]
xref: EC:4.1.1.62
xref: MetaCyc:GENTISATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047924
name: geraniol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: geraniol + NADP+ = geranial + NADPH." [EC:1.1.1.183, MetaCyc:GERANIOL-DEHYDROGENASE-RXN]
synonym: "geraniol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.183]
xref: EC:1.1.1.183
xref: MetaCyc:GERANIOL-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0734
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047925
name: geranoyl-CoA carboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + geranoyl-CoA + HCO3- = ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA." [EC:6.4.1.5, MetaCyc:GERANOYL-COA-CARBOXYLASE-RXN]
synonym: "geranoyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.5]
synonym: "geranoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.5]
synonym: "geranyl-CoA carboxylase activity" EXACT [EC:6.4.1.5]
xref: EC:6.4.1.5
xref: MetaCyc:GERANOYL-COA-CARBOXYLASE-RXN
xref: UM-BBD_enzymeID:e0721
is_a: GO:0016421 ! CoA carboxylase activity

[Term]
id: GO:0047926
name: geranyl-diphosphate cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = (+)-bornyl diphosphate." [EC:5.5.1.8, MetaCyc:GERANYL-DIPHOSPHATE-CYCLASE-RXN]
synonym: "(+)-bornyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.8]
synonym: "(+)-bornylpyrophosphate cyclase activity" EXACT [EC:5.5.1.8]
synonym: "bornyl diphosphate synthase activity" EXACT [EC:5.5.1.8]
synonym: "bornyl pyrophosphate synthase activity" EXACT [EC:5.5.1.8]
synonym: "bornyl pyrophosphate synthetase activity" EXACT [EC:5.5.1.8]
xref: EC:5.5.1.8
xref: MetaCyc:GERANYL-DIPHOSPHATE-CYCLASE-RXN
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0047927
name: gibberellin-44 dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2." [EC:1.14.11.12, MetaCyc:GIBBERELLIN-44-DIOXYGENASE-RXN]
synonym: "(gibberellin-44), 2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.12]
synonym: "(gibberellin-44),2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.12]
synonym: "gibberellin A44 oxidase activity" EXACT [EC:1.14.11.12]
synonym: "oxygenase, gibberellin A44 oxidase activity" EXACT [EC:1.14.11.12]
xref: EC:1.14.11.12
xref: MetaCyc:RXN1F-168
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0047928
name: gibberellin beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside." [EC:2.4.1.176, MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "gibberellin b-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:gibberellin 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.176]
synonym: "UDPglucose:gibberellin 2-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.176]
synonym: "uridine diphosphoglucose-gibberellate 3-O-glucosyltransferase activity" EXACT [EC:2.4.1.176]
synonym: "uridine diphosphoglucose-gibberellate 7-glucosyltransferase activity" EXACT [EC:2.4.1.176]
xref: EC:2.4.1.176
xref: MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0047929
name: gluconate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O." [EC:4.2.1.39, MetaCyc:GLUCONATE-DEHYDRATASE-RXN]
subset: gosubset_prok
synonym: "D-gluconate dehydratase activity" EXACT [EC:4.2.1.39]
synonym: "D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.2.1.39]
synonym: "D-gluconate hydro-lyase activity" EXACT [EC:4.2.1.39]
xref: EC:4.2.1.39
xref: MetaCyc:GLUCONATE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047930
name: glucosaminate ammonia-lyase activity
namespace: molecular_function
alt_id: GO:0050443
def: "Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3." [EC:4.3.1.9, MetaCyc:GLUCOSAMINATE-AMMONIA-LYASE-RXN]
comment: Note that this function was EC:4.3.1.21.
synonym: "2-amino-2-deoxy-D-gluconate ammonia-lyase activity" EXACT [EC:4.3.1.9]
synonym: "2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.9]
synonym: "acetylenemonocarboxylic acid hydrase activity" EXACT [EC:4.3.1.9]
synonym: "aminodeoxygluconate ammonia-lyase activity" EXACT []
synonym: "aminodeoxygluconate dehydratase activity" EXACT []
synonym: "D-glucosaminate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.3.1.9]
synonym: "D-glucosaminate ammonia-lyase activity" EXACT [EC:4.3.1.9]
synonym: "D-glucosaminate dehydratase activity" EXACT [EC:4.3.1.9]
synonym: "D-glucosaminic acid dehydrase activity" EXACT [EC:4.3.1.9]
synonym: "glucosaminic dehydrase activity" EXACT [EC:4.3.1.9]
xref: EC:4.3.1.9
xref: MetaCyc:4.3.1.21-RXN
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0047931
name: glucosamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine phosphate." [EC:2.7.1.8, MetaCyc:GLUCOSAMINE-KINASE-RXN]
synonym: "aminodeoxyglucose kinase activity" EXACT [EC:2.7.1.8]
synonym: "ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase activity" EXACT [EC:2.7.1.8]
synonym: "ATP:D-glucosamine phosphotransferase activity" EXACT [EC:2.7.1.8]
synonym: "glucosamine kinase (phosphorylating)" EXACT [EC:2.7.1.8]
xref: EC:2.7.1.8
xref: MetaCyc:GLUCOSAMINE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047932
name: glucosamine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + D-glucosamine = CoA + N-acetyl-D-glucosamine." [EC:2.3.1.3, MetaCyc:GLUCOSAMINE-N-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA:D-glucosamine N-acetyltransferase activity" EXACT [EC:2.3.1.3]
synonym: "glucosamine acetylase activity" EXACT [EC:2.3.1.3]
synonym: "glucosamine acetyltransferase activity" EXACT [EC:2.3.1.3]
xref: EC:2.3.1.3
xref: MetaCyc:GLUCOSAMINE-N-ACETYLTRANSFERASE-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047933
name: glucose-1,6-bisphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate = 3-phospho-D-glycerate + D-glucose 1,6-bisphosphate." [EC:2.7.1.106, MetaCyc:GLUCOSE-16-BISPHOSPHATE-SYNTHASE-RXN]
synonym: "3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.106]
synonym: "3-phospho-D-glyceroyl-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.106]
synonym: "glucose 1,6-diphosphate synthase activity" EXACT [EC:2.7.1.106]
synonym: "glucose-1,6-bisphosphate synthetase activity" EXACT [EC:2.7.1.106]
xref: EC:2.7.1.106
xref: MetaCyc:GLUCOSE-16-BISPHOSPHATE-SYNTHASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047934
name: glucose 1-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH." [EC:1.1.1.118, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN]
synonym: "D-aldohexose dehydrogenase activity" EXACT [EC:1.1.1.118]
synonym: "D-glucose:NAD oxidoreductase activity" EXACT [EC:1.1.1.118]
synonym: "D-glucose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.118]
xref: EC:1.1.1.118
xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN
is_a: GO:0047936 ! glucose 1-dehydrogenase activity

[Term]
id: GO:0047935
name: glucose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,4-lactone + NADPH." [EC:1.1.1.119, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN]
synonym: "D-glucose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.119]
synonym: "NADP-dependent glucose dehydrogenase activity" EXACT [EC:1.1.1.119]
synonym: "NADP-linked aldohexose dehydrogenase activity" EXACT [EC:1.1.1.119]
synonym: "nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogenase activity" EXACT [EC:1.1.1.119]
xref: EC:1.1.1.119
xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN
is_a: GO:0047936 ! glucose 1-dehydrogenase activity

[Term]
id: GO:0047936
name: glucose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H." [EC:1.1.1.47, MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "beta-D-glucose:NAD(P)+ 1-oxidoreductase activity" EXACT [EC:1.1.1.47]
synonym: "D-glucose dehydrogenase (NAD(P))" EXACT [EC:1.1.1.47]
synonym: "hexose phosphate dehydrogenase activity" EXACT [EC:1.1.1.47]
xref: EC:1.1.1.47
xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047937
name: glucose-1-phosphate phosphodismutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate." [EC:2.7.1.41, MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN]
subset: gosubset_prok
synonym: "D-glucose-1-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.41]
synonym: "glucose 1-phosphate transphosphorylase activity" EXACT [EC:2.7.1.41]
synonym: "phosphodismutase activity" EXACT [EC:2.7.1.41]
xref: EC:2.7.1.41
xref: MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047938
name: glucose-6-phosphate 1-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate." [EC:5.1.3.15, MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN]
synonym: "D-glucose-6-phosphate 1-epimerase activity" EXACT [EC:5.1.3.15]
synonym: "glucose-6 phosphate 1-epimerase activity" EXACT []
xref: EC:5.1.3.15
xref: MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0047939
name: L-glucuronate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gulonate + NADP+ = D-glucuronate + NADPH." [EC:1.1.1.19, MetaCyc:GLUCURONATE-REDUCTASE-RXN]
synonym: "aldehyde reductase II activity" RELATED [EC:1.1.1.19]
synonym: "D-glucuronate dehydrogenase activity" EXACT [EC:1.1.1.19]
synonym: "D-glucuronate reductase activity" NARROW [EC:1.1.1.19]
synonym: "glucuronate dehydrogenase activity" EXACT [EC:1.1.1.19]
synonym: "glucuronate reductase activity" EXACT []
synonym: "NADP-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.19]
synonym: "TPN-L-gulonate dehydrogenase activity" EXACT [EC:1.1.1.19]
xref: EC:1.1.1.19
xref: MetaCyc:GLUCURONATE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047940
name: glucuronokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-glucuronate = ADP + 1-phospho-alpha-D-glucuronate." [EC:2.7.1.43, MetaCyc:GLUCURONOKINASE-RXN]
synonym: "ATP:D-glucuronate 1-phosphotransferase activity" EXACT [EC:2.7.1.43]
synonym: "glucurono-glucuronokinase activity" EXACT [EC:2.7.1.43]
synonym: "glucuronokinase (phosphorylating)" EXACT [EC:2.7.1.43]
xref: EC:2.7.1.43
xref: MetaCyc:GLUCURONOKINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047941
name: glucuronolactone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + NADPH." [EC:1.1.1.20, MetaCyc:GLUCURONOLACTONE-REDUCTASE-RXN]
subset: gosubset_prok
xref: EC:1.1.1.20
xref: MetaCyc:GLUCURONOLACTONE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047942
name: glutamate-ethylamine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-glutamate + ethylamine = ADP + phosphate + N5-ethyl-L-glutamine." [EC:6.3.1.6, MetaCyc:GLUTAMATE--ETHYLAMINE-LIGASE-RXN]
synonym: "L-glutamate:ethylamine ligase (ADP-forming)" EXACT [EC:6.3.1.6]
synonym: "N(5)-ethyl-L-glutamine synthetase activity" EXACT [EC:6.3.1.6]
synonym: "N5-ethyl-L-glutamine synthetase activity" EXACT [EC:6.3.1.6]
synonym: "N5-ethylglutamine synthetase activity" EXACT [EC:6.3.1.6]
synonym: "theanine synthetase activity" EXACT [EC:6.3.1.6]
xref: EC:6.3.1.6
xref: MetaCyc:GLUTAMATE--ETHYLAMINE-LIGASE-RXN
is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity

[Term]
id: GO:0047943
name: glutamate-methylamine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-glutamate + methylamine = ADP + phosphate + N5-methyl-L-glutamine." [EC:6.3.4.12, MetaCyc:GLUTAMATE--METHYLAMINE-LIGASE-RXN]
synonym: "gamma-glutamylmethylamide synthetase activity" EXACT [EC:6.3.4.12]
synonym: "L-glutamate:methylamine ligase (ADP-forming)" EXACT [EC:6.3.4.12]
xref: EC:6.3.4.12
xref: MetaCyc:GLUTAMATE--METHYLAMINE-LIGASE-RXN
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0047944
name: glutamate 1-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-glutamate = ADP + alpha-L-glutamyl phosphate." [EC:2.7.2.13, MetaCyc:GLUTAMATE-1-KINASE-RXN]
synonym: "ATP:L-glutamate 1-phosphotransferase activity" EXACT [EC:2.7.2.13]
xref: EC:2.7.2.13
xref: MetaCyc:GLUTAMATE-1-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0047945
name: L-glutamine:pyruvate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine." [EC:2.6.1.15, MetaCyc:GLUTAMINE--PYRUVATE-AMINOTRANSFERASE-RXN]
subset: gosubset_prok
synonym: "gamma-glutaminyltransferase activity" RELATED [EC:2.6.1.15]
synonym: "glutaminase II activity" RELATED [EC:2.6.1.15]
synonym: "glutamine transaminase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine transaminase L activity" BROAD [EC:2.6.1.15]
synonym: "glutamine--oxo-acid transaminase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine--pyruvate aminotransferase activity" BROAD []
synonym: "glutamine-alpha-keto acid transamidase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine-alpha-keto acid transaminase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine-keto acid aminotransferase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine-oxo acid aminotransferase activity" BROAD [EC:2.6.1.15]
synonym: "glutamine-pyruvate transaminase activity" BROAD [EC:2.6.1.15]
synonym: "L-glutamine transaminase L" RELATED [EC:2.6.1.15]
xref: EC:2.6.1.15
xref: MetaCyc:GLUTAMINE--PYRUVATE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047946
name: glutamine N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine." [EC:2.3.1.68, MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN]
synonym: "acyl-CoA:L-glutamine N-acyltransferase activity" EXACT [EC:2.3.1.68]
xref: EC:2.3.1.68
xref: MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0047947
name: glutamine N-phenylacetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine." [EC:2.3.1.14, MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN]
synonym: "glutamine phenylacetyltransferase activity" EXACT [EC:2.3.1.14]
synonym: "phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase activity" EXACT [EC:2.3.1.14]
synonym: "phenylacetyl-CoA:L-glutamine N-acetyltransferase activity" EXACT [EC:2.3.1.14]
xref: EC:2.3.1.14
xref: MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047948
name: glutarate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + glutarate + CoA = ADP + phosphate + glutaryl-CoA." [EC:6.2.1.6, MetaCyc:GLUTARATE--COA-LIGASE-RXN]
synonym: "glutarate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.6]
synonym: "glutaryl coenzyme A synthetase activity" EXACT [EC:6.2.1.6]
synonym: "glutaryl-CoA synthetase activity" EXACT [EC:6.2.1.6]
xref: EC:6.2.1.6
xref: MetaCyc:GLUTARATE--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0047949
name: glutarate-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: glutarate semialdehyde + NAD+ + H2O = glutarate + NADH." [EC:1.2.1.20, MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN]
synonym: "glutarate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.20]
synonym: "glutarate-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.20]
xref: EC:1.2.1.20
xref: MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047950
name: glutathione oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 glutathione + O2 = oxidized glutathione + H2O2." [EC:1.8.3.3, MetaCyc:GLUTATHIONE-OXIDASE-RXN]
synonym: "glutathione:oxygen oxidoreductase activity" EXACT [EC:1.8.3.3]
xref: EC:1.8.3.3
xref: MetaCyc:GLUTATHIONE-OXIDASE-RXN
is_a: GO:0016670 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor

[Term]
id: GO:0047951
name: glutathione thiolesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-acylglutathione + H2O = glutathione + a carboxylate." [EC:3.1.2.7, MetaCyc:GLUTATHIONE-THIOESTERASE-RXN]
synonym: "citryl-glutathione thioesterhydrolase activity" EXACT [EC:3.1.2.7]
synonym: "glutathione thioesterase activity" EXACT []
synonym: "S-acylglutathione hydrolase activity" EXACT [EC:3.1.2.7]
xref: EC:3.1.2.7
xref: MetaCyc:GLUTATHIONE-THIOESTERASE-RXN
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0047952
name: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [EC:1.1.1.94, MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN]
subset: gosubset_prok
synonym: "glycerol 3-phosphate dehydrogenase (NAD(P)) activity" EXACT [EC:1.1.1.94]
synonym: "glycerol 3-phosphate dehydrogenase (NADP) activity" EXACT [EC:1.1.1.94]
synonym: "glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.1.1.94]
synonym: "glycerol-3-phosphate dehydrogenase (NAD(P)+) activity" EXACT []
synonym: "L-glycerol-3-phosphate:NAD(P) oxidoreductase activity" EXACT [EC:1.1.1.94]
synonym: "sn-glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.94]
xref: EC:1.1.1.94
xref: MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047953
name: glycerol 2-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol + NADP+ = glycerone + NADPH." [EC:1.1.1.156, MetaCyc:GLYCEROL-2-DEHYDROGENASE-NADP+-RXN]
synonym: "DHA oxidoreductase activity" EXACT [EC:1.1.1.156]
synonym: "dihydroxyacetone (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.156]
synonym: "dihydroxyacetone reductase (NADPH)" EXACT [EC:1.1.1.156]
synonym: "dihydroxyacetone reductase activity" EXACT [EC:1.1.1.156]
synonym: "glycerol:NADP+ 2-oxidoreductase (glycerone-forming)" EXACT [EC:1.1.1.156]
xref: EC:1.1.1.156
xref: MetaCyc:GLYCEROL-2-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047954
name: glycerol-2-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol 2-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.19, MetaCyc:GLYCEROL-2-PHOSPHATASE-RXN]
synonym: "2-glycerophosphatase activity" EXACT [EC:3.1.3.19]
synonym: "beta-glycerophosphatase activity" EXACT [EC:3.1.3.19]
synonym: "beta-glycerophosphate phosphatase activity" EXACT [EC:3.1.3.19]
synonym: "glycerol-2-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.19]
xref: EC:3.1.3.19
xref: MetaCyc:GLYCEROL-2-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0047955
name: glycerol dehydrogenase (acceptor) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol + acceptor = glycerone + reduced acceptor." [EC:1.1.99.22, MetaCyc:GLYCEROL-DEHYDROGENASE-ACCEPTOR-RXN]
synonym: "glycerol:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.22]
synonym: "glycerol:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.22]
xref: EC:1.1.99.22
xref: MetaCyc:GLYCEROL-DEHYDROGENASE-ACCEPTOR-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047956
name: glycerol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH." [EC:1.1.1.72, MetaCyc:GLYCEROL-DEHYDROGENASE-NADP+-RXN]
synonym: "glycerol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.72]
xref: EC:1.1.1.72
xref: MetaCyc:GLYCEROL-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047957
name: 4'-methoxyisoflavone 2'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: formononetin + NADPH + O2 = 2'-hydroxyformononetin + NADP+ + H2O." [EC:1.14.13.53, MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN]
synonym: "formononetin,NADPH:oxygen oxidoreductase (2'-hydroxylating)" EXACT [EC:1.14.13.53]
synonym: "isoflavone 2'-monooxygenase activity" BROAD [EC:1.14.13.53]
xref: EC:1.14.13.53
xref: MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0047958
name: glycine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate." [EC:2.6.1.4, MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN]
synonym: "glutamate-glyoxylate transaminase activity" EXACT []
synonym: "glutamic-glyoxylic transaminase activity" EXACT [EC:2.6.1.4]
synonym: "glycine aminotransferase activity" BROAD []
synonym: "glycine transaminase activity" BROAD [EC:2.6.1.4]
synonym: "glyoxylate-glutamate aminotransferase activity" EXACT [EC:2.6.1.4]
synonym: "glyoxylate-glutamic transaminase activity" EXACT [EC:2.6.1.4]
synonym: "L-glutamate:glyoxylate aminotransferase activity" EXACT []
xref: EC:2.6.1.4
xref: MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0047959
name: glycine dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c." [EC:1.4.2.1, MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN]
synonym: "glycine-cytochrome c reductase activity" EXACT [EC:1.4.2.1]
synonym: "glycine:ferricytochrome-c oxidoreductase (deaminating)" EXACT [EC:1.4.2.1]
synonym: "reductase, glycine-cytochrome c" EXACT [EC:1.4.2.1]
xref: EC:1.4.2.1
xref: MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN
is_a: GO:0016640 ! oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor

[Term]
id: GO:0047960
name: glycine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + H2O + NAD+ = glyoxylate + NH3 + NADH." [EC:1.4.1.10, MetaCyc:GLYCINE-DEHYDROGENASE-RXN]
synonym: "glycine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.10]
xref: EC:1.4.1.10
xref: MetaCyc:GLYCINE-DEHYDROGENASE-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047961
name: glycine N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine." [EC:2.3.1.13, MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN]
synonym: "acyl-CoA:glycine N-acyltransferase activity" EXACT [EC:2.3.1.13]
synonym: "glycine acyltransferase activity" EXACT [EC:2.3.1.13]
synonym: "glycine-N-acylase activity" EXACT [EC:2.3.1.13]
xref: EC:2.3.1.13
xref: MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0047962
name: glycine N-benzoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoyl-CoA + glycine = CoA + N-benzoylglycine." [EC:2.3.1.71, MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN]
synonym: "benzoyl CoA-amino acid N-acyltransferase activity" EXACT [EC:2.3.1.71]
synonym: "benzoyl-CoA:glycine N-acyltransferase activity" EXACT [EC:2.3.1.71]
synonym: "benzoyl-CoA:glycine N-benzoyltransferase activity" EXACT [EC:2.3.1.71]
xref: EC:2.3.1.71
xref: MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047963
name: glycine N-choloyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate." [EC:2.3.1.65, MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN]
synonym: "amino acid N-choloyltransferase activity" EXACT [EC:2.3.1.65]
synonym: "BACAT activity" EXACT [EC:2.3.1.65]
synonym: "BAT activity" EXACT [EC:2.3.1.65]
synonym: "bile acid-CoA:amino acid N-acyltransferase activity" EXACT [EC:2.3.1.65]
synonym: "choloyl-CoA:glycine N-choloyltransferase activity" EXACT [EC:2.3.1.65]
synonym: "cholyl-CoA glycine-taurine N-acyltransferase activity" EXACT [EC:2.3.1.65]
synonym: "cholyl-CoA:taurine N-acyltransferase activity" EXACT [EC:2.3.1.65]
synonym: "glycine--taurine N-acyltransferase activity" EXACT [EC:2.3.1.65]
xref: EC:2.3.1.65
xref: MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0047964
name: glyoxylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH." [EC:1.1.1.26, MetaCyc:GLYCOLATE-REDUCTASE-RXN]
subset: gosubset_prok
synonym: "glycolate reductase activity" EXACT []
synonym: "glyoxylic acid reductase activity" EXACT [EC:1.1.1.26]
synonym: "NADH-dependent glyoxylate reductase activity" EXACT [EC:1.1.1.26]
xref: EC:1.1.1.26
xref: MetaCyc:GLYCOLATE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047965
name: glycoprotein O-fatty-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein." [EC:2.3.1.142, MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN]
synonym: "fatty-acyl-CoA:mucus-glycoprotein fatty-acyltransferase activity" EXACT [EC:2.3.1.142]
synonym: "protein acyltransferase activity" EXACT [EC:2.3.1.142]
xref: EC:2.3.1.142
xref: MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN
is_a: GO:0016416 ! O-palmitoyltransferase activity

[Term]
id: GO:0047966
name: glycosulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose 6-sulfate + H2O = D-glucose + SO4(2-) (sulfate)." [EC:3.1.6.3, MetaCyc:GLYCOSULFATASE-RXN]
synonym: "glucosulfatase activity" EXACT [EC:3.1.6.3]
synonym: "glycosulphatase activity" EXACT []
synonym: "sugar-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.3]
xref: EC:3.1.6.3
xref: MetaCyc:GLYCOSULFATASE-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0047967
name: glycyrrhizinate beta-glucuronidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + glycyrrhizinate = 1,2-beta-D-glucuronosyl-D-glucuronate + glycyrrhetinate." [EC:3.2.1.128, MetaCyc:GLYCYRRHIZINATE-BETA-GLUCURONIDASE-RXN]
synonym: "glycyrrhizin beta-hydrolase activity" EXACT [EC:3.2.1.128]
synonym: "glycyrrhizin hydrolase activity" EXACT [EC:3.2.1.128]
synonym: "glycyrrhizinate b-glucuronidase activity" EXACT []
synonym: "glycyrrhizinate glucuronosylhydrolase activity" EXACT [EC:3.2.1.128]
synonym: "glycyrrhizinic acid hydrolase activity" EXACT [EC:3.2.1.128]
xref: EC:3.2.1.128
xref: MetaCyc:GLYCYRRHIZINATE-BETA-GLUCURONIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0047968
name: glyoxylate dehydrogenase (acylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxylate + CoA + NADP+ = oxalyl-CoA + NADPH." [EC:1.2.1.17, MetaCyc:GLYOXYLATE-DEHYDROGENASE-ACYLATING-RXN]
synonym: "glyoxylate:NADP+ oxidoreductase (CoA-oxalylating)" EXACT [EC:1.2.1.17]
xref: EC:1.2.1.17
xref: MetaCyc:GLYOXYLATE-DEHYDROGENASE-ACYLATING-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047969
name: glyoxylate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: glyoxylate + H2O + O2 = oxalate + H2O2." [EC:1.2.3.5, MetaCyc:GLYOXYLATE-OXIDASE-RXN]
synonym: "glyoxylate:oxygen oxidoreductase activity" EXACT [EC:1.2.3.5]
xref: EC:1.2.3.5
xref: MetaCyc:GLYOXYLATE-OXIDASE-RXN
xref: Reactome:79800 "glyoxylate oxidase activity"
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0047970
name: guanidinoacetase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanidinoacetate + H2O = glycine + urea." [EC:3.5.3.2, MetaCyc:GUANIDINOACETASE-RXN]
synonym: "glycocyaminase activity" EXACT [EC:3.5.3.2]
synonym: "guanidinoacetate amidinohydrolase activity" EXACT [EC:3.5.3.2]
xref: EC:3.5.3.2
xref: MetaCyc:GUANIDINOACETASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047971
name: guanidinobutyrase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-guanidinobutanoate + H2O = 4-aminobutanoate + urea." [EC:3.5.3.7, MetaCyc:GUANIDINOBUTYRASE-RXN]
subset: gosubset_prok
synonym: "4-guanidinobutanoate amidinohydrolase activity" EXACT [EC:3.5.3.7]
synonym: "4-guanidinobutyrate amidinobutyrase activity" EXACT [EC:3.5.3.7]
synonym: "G-base activity" EXACT [EC:3.5.3.7]
synonym: "gamma-guanidinobutyrate amidinohydrolase activity" EXACT [EC:3.5.3.7]
synonym: "gamma-guanidobutyrase activity" EXACT [EC:3.5.3.7]
synonym: "GBH" RELATED [EC:3.5.3.7]
synonym: "guanidinobutyrate ureahydrolase activity" EXACT [EC:3.5.3.7]
xref: EC:3.5.3.7
xref: MetaCyc:GUANIDINOBUTYRASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047972
name: guanidinopropionase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-guanidinopropanoate + H2O = beta-alanine + urea." [EC:3.5.3.17, MetaCyc:GUANIDINOPROPIONASE-RXN]
synonym: "3-guanidinopropanoate amidinopropionase activity" EXACT [EC:3.5.3.17]
synonym: "GPase activity" EXACT [EC:3.5.3.17]
synonym: "GPH" RELATED [EC:3.5.3.17]
xref: EC:3.5.3.17
xref: MetaCyc:GUANIDINOPROPIONASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0047973
name: guanidinoacetate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + guanidinoacetate = ADP + phosphoguanidinoacetate." [EC:2.7.3.1, MetaCyc:GUANIDOACETATE-KINASE-RXN]
synonym: "ATP:guanidinoacetate N-phosphotransferase activity" EXACT [EC:2.7.3.1]
synonym: "glycocyamine kinase activity" EXACT [EC:2.7.3.1]
synonym: "guanidoacetate kinase activity" EXACT []
xref: EC:2.7.3.1
xref: MetaCyc:GUANIDOACETATE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0047974
name: guanosine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine + H2O = xanthosine + NH3." [EC:3.5.4.15, MetaCyc:GUANOSINE-DEAMINASE-RXN]
synonym: "guanosine aminase activity" EXACT [EC:3.5.4.15]
synonym: "guanosine aminohydrolase activity" EXACT [EC:3.5.4.15]
xref: EC:3.5.4.15
xref: MetaCyc:GUANOSINE-DEAMINASE-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0047975
name: guanosine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate." [EC:2.4.2.15, MetaCyc:GUANPHOSPHOR-RXN]
synonym: "guanosine:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.15]
synonym: "guanosine:phosphate D-ribosyltransferase activity" EXACT [EC:2.4.2.15]
xref: EC:2.4.2.15
xref: MetaCyc:GUANPHOSPHOR-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0047976
name: hamamelose kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-hamamelose = ADP + D-hamamelose 2'-phosphate." [EC:2.7.1.102, MetaCyc:HAMAMELOSE-KINASE-RXN]
synonym: "ATP/hamamelose 2'-phosphotransferase activity" EXACT [EC:2.7.1.102]
synonym: "ATP:D-hamamelose 2'-phosphotransferase activity" EXACT [EC:2.7.1.102]
synonym: "hamamelose kinase (phosphorylating)" EXACT [EC:2.7.1.102]
synonym: "hamamelosekinase (ATP: hamamelose 2'-phosphotransferase)" EXACT [EC:2.7.1.102]
xref: EC:2.7.1.102
xref: MetaCyc:HAMAMELOSE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047977
name: hepoxilin-epoxide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate." [EC:3.3.2.7, MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN]
synonym: "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase activity" EXACT [EC:3.3.2.7]
synonym: "hepoxilin A(3) hydrolase activity" RELATED [EC:3.3.2.7]
synonym: "hepoxilin A3 hydrolase activity" EXACT [EC:3.3.2.7]
synonym: "hepoxilin epoxide hydrolase activity" EXACT [EC:3.3.2.7]
synonym: "hepoxylin hydrolase activity" RELATED [EC:3.3.2.7]
xref: EC:3.3.2.7
xref: MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0047978
name: hexadecanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hexadecanol + NAD+ = hexadecanal + NADH." [EC:1.1.1.164, MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN]
synonym: "hexadecanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.164]
xref: EC:1.1.1.164
xref: MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047979
name: hexose oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2." [EC:1.1.3.5, MetaCyc:HEXOSE-OXIDASE-RXN]
synonym: "D-hexose:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.5]
xref: EC:1.1.3.5
xref: MetaCyc:HEXOSE-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047980
name: hippurate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: hippurate + H2O = benzoate + glycine." [EC:3.5.1.32, MetaCyc:HIPPURATE-HYDROLASE-RXN]
subset: gosubset_prok
synonym: "benzoylglycine amidohydrolase activity" EXACT [EC:3.5.1.32]
synonym: "hippuricase activity" EXACT [EC:3.5.1.32]
synonym: "N-benzoylamino-acid amidohydrolase activity" EXACT [EC:3.5.1.32]
xref: EC:3.5.1.32
xref: MetaCyc:HIPPURATE-HYDROLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0047981
name: histidine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + L-histidine = CoA + N-acetyl-L-histidine." [EC:2.3.1.33, MetaCyc:HISTIDINE-N-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA:L-histidine N-acetyltransferase activity" EXACT [EC:2.3.1.33]
synonym: "acetylhistidine synthetase activity" EXACT [EC:2.3.1.33]
synonym: "histidine acetyltransferase activity" EXACT [EC:2.3.1.33]
xref: EC:2.3.1.33
xref: MetaCyc:HISTIDINE-N-ACETYLTRANSFERASE-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0047982
name: homocysteine desulfhydrase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate." [EC:4.4.1.2, MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN]
synonym: "homocysteine desulfurase activity" EXACT [EC:4.4.1.2]
synonym: "L-homocysteine hydrogen-sulfide-lyase (deaminating)" EXACT [EC:4.4.1.2]
synonym: "L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.2]
xref: EC:4.4.1.2
xref: MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0047983
name: homoglutathione synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + gamma-L-glutamyl-L-cysteine + beta-alanine = ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine." [EC:6.3.2.23, MetaCyc:HOMOGLUTATHIONE-SYNTHASE-RXN]
synonym: "beta-alanine specific hGSH synthetase activity" EXACT [EC:6.3.2.23]
synonym: "gamma-L-glutamyl-L-cysteine:beta-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.23]
synonym: "homoglutathione synthetase activity" EXACT [EC:6.3.2.23]
xref: EC:6.3.2.23
xref: MetaCyc:HOMOGLUTATHIONE-SYNTHASE-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0047985
name: hydrogen dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2 + NAD+ = H+ + NADH." [EC:1.12.1.2, MetaCyc:HYDROGEN-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.1.2]
synonym: "H(2):NAD(+) oxidoreductase activity" EXACT [EC:1.12.1.2]
synonym: "H2:NAD+ oxidoreductase activity" EXACT [EC:1.12.1.2]
synonym: "hydrogen:NAD+ oxidoreductase activity" EXACT [EC:1.12.1.2]
synonym: "hydrogenase activity" BROAD [EC:1.12.1.2]
synonym: "NAD-linked hydrogenase activity" EXACT [EC:1.12.1.2]
xref: EC:1.12.1.2
xref: MetaCyc:HYDROGEN-DEHYDROGENASE-RXN
is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor

[Term]
id: GO:0047986
name: hydrogen-sulfide S-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + hydrogen sulfide = CoA + thioacetate." [EC:2.3.1.10, MetaCyc:HYDROGEN-SULFIDE-S-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA:hydrogen-sulfide S-acetyltransferase activity" EXACT [EC:2.3.1.10]
synonym: "hydrogen-sulfide acetyltransferase activity" EXACT [EC:2.3.1.10]
synonym: "hydrogen-sulphide S-acetyltransferase activity" EXACT []
xref: EC:2.3.1.10
xref: MetaCyc:HYDROGEN-SULFIDE-S-ACETYLTRANSFERASE-RXN
is_a: GO:0016418 ! S-acetyltransferase activity

[Term]
id: GO:0047987
name: hydroperoxide dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate = (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H2O." [EC:4.2.1.92, MetaCyc:HYDROPEROXIDE-DEHYDRATASE-RXN]
synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]" RELATED [EC:4.2.1.92]
synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase activity" EXACT [EC:4.2.1.92]
synonym: "HPI" RELATED [EC:4.2.1.92]
synonym: "hydroperoxide isomerase activity" EXACT [EC:4.2.1.92]
synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92]
synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92]
xref: EC:4.2.1.92
xref: MetaCyc:HYDROPEROXIDE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0047988
name: hydroxyacid-oxoacid transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate." [EC:1.1.99.24, MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN]
synonym: "(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity" EXACT [EC:1.1.99.24]
synonym: "transhydrogenase, hydroxy acid-oxo acid" EXACT [EC:1.1.99.24]
xref: EC:1.1.99.24
xref: MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0047989
name: hydroxybutyrate-dimer hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O = 2 (R)-3-hydroxybutanoate." [EC:3.1.1.22, MetaCyc:HYDROXYBUTYRATE-DIMER-HYDROLASE-RXN]
subset: gosubset_prok
synonym: "(R)-3-((R)-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase activity" EXACT [EC:3.1.1.22]
synonym: "D-(-)-3-hydroxybutyrate-dimer hydrolase activity" EXACT [EC:3.1.1.22]
xref: EC:3.1.1.22
xref: MetaCyc:HYDROXYBUTYRATE-DIMER-HYDROLASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0047990
name: hydroxyglutamate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-L-glutamate = 4-amino-3-hydroxybutanoate + CO2." [EC:4.1.1.16, MetaCyc:HYDROXYGLUTAMATE-DECARBOXYLASE-RXN]
synonym: "3-hydroxy-L-glutamate 1-carboxy-lyase (4-amino-3-hydroxybutanoate-forming)" EXACT [EC:4.1.1.16]
synonym: "3-hydroxy-L-glutamate 1-carboxy-lyase activity" EXACT [EC:4.1.1.16]
xref: EC:4.1.1.16
xref: MetaCyc:HYDROXYGLUTAMATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047991
name: hydroxylamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxylamine + O2 = NO2(-) (nitrite) + H2O." [EC:1.7.3.4, MetaCyc:HYDROXYLAMINE-OXIDASE-RXN]
subset: gosubset_prok
synonym: "HAO" RELATED [EC:1.7.3.4]
synonym: "hydroxylamine oxidoreductase" BROAD [EC:1.7.3.4]
synonym: "hydroxylamine:oxygen oxidoreductase activity" EXACT [EC:1.7.3.4]
xref: EC:1.7.3.4
xref: MetaCyc:HYDROXYLAMINE-OXIDASE-RXN
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

[Term]
id: GO:0047992
name: hydroxylysine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 5-hydroxy-L-lysine = GDP + 5-phosphonooxy-L-lysine." [EC:2.7.1.81, MetaCyc:HYDROXYLYSINE-KINASE-RXN]
synonym: "GTP:5-hydroxy-L-lysine O-phosphotransferase activity" EXACT [EC:2.7.1.81]
synonym: "guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase activity" EXACT [EC:2.7.1.81]
synonym: "hydroxylysine kinase (phosphorylating)" EXACT [EC:2.7.1.81]
xref: EC:2.7.1.81
xref: MetaCyc:HYDROXYLYSINE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0047993
name: hydroxymalonate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxymalonate + NAD+ = oxomalonate + NADH." [EC:1.1.1.167, MetaCyc:HYDROXYMALONATE-DEHYDROGENASE-RXN]
synonym: "hydroxymalonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.167]
xref: EC:1.1.1.167
xref: MetaCyc:HYDROXYMALONATE-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047994
name: hydroxymethylglutaryl-CoA hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H2O = CoA + 3-hydroxy-3-methylglutarate." [EC:3.1.2.5, MetaCyc:HYDROXYMETHYLGLUTARYL-COA-HYDROLASE-RXN]
synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydrolase activity" EXACT [EC:3.1.2.5]
synonym: "3-hydroxy-3-methylglutaryl-CoA hydrolase activity" EXACT [EC:3.1.2.5]
synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A deacylase activity" EXACT [EC:3.1.2.5]
synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase activity" EXACT [EC:3.1.2.5]
synonym: "hydroxymethylglutaryl coenzyme A deacylase activity" EXACT [EC:3.1.2.5]
synonym: "hydroxymethylglutaryl coenzyme A hydrolase activity" EXACT [EC:3.1.2.5]
xref: EC:3.1.2.5
xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-HYDROLASE-RXN
is_a: GO:0016289 ! CoA hydrolase activity

[Term]
id: GO:0047995
name: hydroxyphenylpyruvate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH." [EC:1.1.1.237, MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN]
synonym: "4-hydroxyphenyllactate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.237]
synonym: "HPRP" RELATED [EC:1.1.1.237]
xref: EC:1.1.1.237
xref: MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0047996
name: hydroxyphytanate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-hydroxyphytanate + O2 = 2-oxophytanate + H2O2." [EC:1.1.3.27, MetaCyc:HYDROXYPHYTANATE-OXIDASE-RXN]
synonym: "L-2-hydroxyphytanate:oxygen 2-oxidoreductase" BROAD [EC:1.1.3.27]
xref: EC:1.1.3.27
xref: MetaCyc:HYDROXYPHYTANATE-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0047997
name: hydroxypyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroxypyruvate = glycolaldehyde + CO2." [EC:4.1.1.40, MetaCyc:HYDROXYPYRUVATE-DECARBOXYLASE-RXN]
synonym: "hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)" EXACT [EC:4.1.1.40]
synonym: "hydroxypyruvate carboxy-lyase activity" EXACT [EC:4.1.1.40]
xref: EC:4.1.1.40
xref: MetaCyc:HYDROXYPYRUVATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0047998
name: hyoscyamine (6S)-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-hyoscyamine + 2-oxoglutarate + O2 = (6S)-hydroxyhyoscyamine + succinate + CO2." [EC:1.14.11.11, MetaCyc:HYOSCYAMINE-6-DIOXYGENASE-RXN]
synonym: "hyoscyamine (6S)-hydroxylase activity" EXACT [EC:1.14.11.11]
synonym: "hyoscyamine 6-beta-hydroxylase activity" EXACT [EC:1.14.11.11]
synonym: "hyoscyamine 6-hydroxylase activity" EXACT [EC:1.14.11.11]
synonym: "hyoscyamine 6beta-dioxygenase activity" EXACT [EC:1.14.11.11]
synonym: "hyoscyamine 6beta-hydroxylase activity" EXACT [EC:1.14.11.11]
synonym: "L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase ((6S)-hydroxylating)" EXACT [EC:1.14.11.11]
xref: EC:1.14.11.11
xref: MetaCyc:HYOSCYAMINE-6-DIOXYGENASE-RXN
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0047999
name: hyponitrite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 hydroxylamine + 2 NAD+ = hyponitrous acid + 2 NADH + 2 H+." [EC:1.7.1.5, MetaCyc:HYPONITRITE-REDUCTASE-RXN]
synonym: "hydroxylamine:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.5]
synonym: "NADH2:hyponitrite oxidoreductase activity" EXACT [EC:1.7.1.5]
synonym: "NADH:hyponitrite oxidoreductase activity" EXACT [EC:1.7.1.5]
xref: EC:1.7.1.5
xref: MetaCyc:HYPONITRITE-REDUCTASE-RXN
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0048000
name: isoflavone 3'-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O." [EC:1.14.13.52, MetaCyc:ISOFLAVONE-3'-HYDROXYLASE-RXN]
synonym: "formononetin,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.52]
synonym: "isoflavone 3'-monooxygenase activity" EXACT [EC:1.14.13.52]
xref: EC:1.14.13.52
xref: MetaCyc:RXN-3762
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0048001
name: erythrose-4-phosphate dehydrogenase activity
namespace: molecular_function
alt_id: GO:0033724
def: "Catalysis of the reaction: D-erythrose 4-phosphate + NAD+ + H2O = 4-phosphoerythronate + NADH + 2 H+." [EC:1.2.1.72, MetaCyc:ERYTH4PDEHYDROG-RXN]
synonym: "D-erythrose 4-phosphate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.72]
synonym: "E4P dehydrogenase activity" EXACT [EC:1.2.1.72]
synonym: "E4PDH" EXACT [EC:1.2.1.72]
synonym: "Epd dehydrogenase activity" EXACT [EC:1.2.1.72]
synonym: "erythrose 4-phosphate dehydrogenase activity" EXACT [EC:1.2.1.72]
synonym: "GapB" RELATED [EC:1.2.1.72]
xref: EC:1.2.1.72
xref: MetaCyc:ERYTH4PDEHYDROG-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0048002
name: antigen processing and presentation of peptide antigen
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591]
synonym: "antigen presentation, peptide antigen" EXACT []
synonym: "peptide antigen processing and presentation" EXACT []
is_a: GO:0019882 ! antigen processing and presentation

[Term]
id: GO:0048003
name: antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680]
synonym: "antigen presentation, lipid antigen" EXACT []
synonym: "lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib

[Term]
id: GO:0048006
name: antigen processing and presentation, endogenous lipid antigen via MHC class Ib
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680]
synonym: "antigen presentation, endogenous lipid antigen" EXACT []
synonym: "endogenous lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen
is_a: GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0048007
name: antigen processing and presentation, exogenous lipid antigen via MHC class Ib
namespace: biological_process
def: "The process by which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680]
synonym: "antigen presentation, exogenous peptide antigen" EXACT []
synonym: "exogenous lipid antigen processing and presentation via MHC class Ib" EXACT []
is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen
is_a: GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib

[Term]
id: GO:0048008
name: platelet-derived growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands." [GOC:ceb]
synonym: "PDGF receptor signaling pathway" EXACT []
synonym: "PDGF receptor signalling pathway" EXACT []
synonym: "PDGFR signaling pathway" EXACT []
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048009
name: insulin-like growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands." [GOC:ceb]
synonym: "IGF receptor signaling pathway" EXACT []
synonym: "IGF receptor signalling pathway" EXACT []
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048010
name: vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands." [GOC:ceb]
synonym: "VEGF receptor signaling pathway" EXACT []
synonym: "VEGF receptor signalling pathway" EXACT []
xref: Reactome:194138 "Signaling by VEGF"
xref: Reactome:194313 "VEGF ligand-receptor interactions"
xref: Reactome:449143 "VEGF ligand-receptor interactions"
xref: Reactome:449144 "Signaling by VEGF"
xref: Reactome:470257 "VEGF ligand-receptor interactions"
xref: Reactome:470258 "Signaling by VEGF"
xref: Reactome:487936 "VEGF ligand-receptor interactions"
xref: Reactome:487937 "Signaling by VEGF"
xref: Reactome:507907 "VEGF ligand-receptor interactions"
xref: Reactome:507908 "Signaling by VEGF"
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048011
name: nerve growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the nerve growth factor receptor binding to one of its physiological ligands." [GOC:ceb]
synonym: "nerve growth factor receptor signalling pathway" EXACT []
synonym: "NGF receptor signaling pathway" EXACT []
synonym: "NGF receptor signalling pathway" EXACT []
xref: Reactome:166520 "Signalling by NGF"
xref: Reactome:187042 "TRKA activation by NGF"
xref: Reactome:193704 "p75 NTR receptor-mediated signalling"
xref: Reactome:205017 "NFG and proNGF binds to p75NTR"
xref: Reactome:448465 "Signalling by NGF"
xref: Reactome:448510 "p75 NTR receptor-mediated signalling"
xref: Reactome:448665 "TRKA activation by NGF"
xref: Reactome:448923 "NFG and proNGF binds to p75NTR"
xref: Reactome:469595 "Signalling by NGF"
xref: Reactome:469640 "p75 NTR receptor-mediated signalling"
xref: Reactome:469793 "TRKA activation by NGF"
xref: Reactome:470040 "NFG and proNGF binds to p75NTR"
xref: Reactome:487314 "Signalling by NGF"
xref: Reactome:487487 "TRKA activation by NGF"
xref: Reactome:487552 "p75 NTR receptor-mediated signalling"
xref: Reactome:487740 "NFG and proNGF binds to p75NTR"
xref: Reactome:507265 "Signalling by NGF"
xref: Reactome:507447 "TRKA activation by NGF"
xref: Reactome:507508 "p75 NTR receptor-mediated signalling"
xref: Reactome:507695 "NFG and proNGF binds to p75NTR"
xref: Reactome:517291 "Signalling by NGF"
xref: Reactome:517493 "p75 NTR receptor-mediated signalling"
xref: Reactome:526169 "Signalling by NGF"
xref: Reactome:526362 "p75 NTR receptor-mediated signalling"
xref: Reactome:531217 "Signalling by NGF"
xref: Reactome:531480 "p75 NTR receptor-mediated signalling"
xref: Reactome:536587 "Signalling by NGF"
xref: Reactome:536865 "p75 NTR receptor-mediated signalling"
xref: Reactome:542313 "Signalling by NGF"
xref: Reactome:542619 "p75 NTR receptor-mediated signalling"
xref: Reactome:547653 "Signalling by NGF"
xref: Reactome:547935 "p75 NTR receptor-mediated signalling"
xref: Reactome:552324 "Signalling by NGF"
xref: Reactome:557823 "Signalling by NGF"
xref: Reactome:568455 "Signalling by NGF"
xref: Reactome:581653 "Signalling by NGF"
xref: Reactome:585819 "Signalling by NGF"
xref: Reactome:592565 "Signalling by NGF"
xref: Reactome:595385 "Signalling by NGF"
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048012
name: hepatocyte growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands." [GOC:ceb]
synonym: "HGF receptor signaling pathway" EXACT []
synonym: "HGF receptor signalling pathway" EXACT []
synonym: "Met signaling pathway" NARROW []
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048013
name: ephrin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin." [GOC:ceb]
synonym: "Eph receptor signaling pathway" EXACT []
synonym: "Eph receptor signalling pathway" EXACT []
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048014
name: Tie receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a Tie receptor binding to one of its physiological ligands (angiopoietins)." [GOC:ceb]
synonym: "Tek receptor signaling" EXACT []
synonym: "Tie receptor signalling pathway" EXACT []
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway

[Term]
id: GO:0048015
name: phosphoinositide-mediated signaling
namespace: biological_process
def: "A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response." [GOC:ceb, PMID:11331907]
subset: gosubset_prok
synonym: "inositol phospholipid-mediated signaling" BROAD []
synonym: "phosphoinositide-mediated signalling" EXACT []
xref: Reactome:198203 "PI3K/AKT signalling"
xref: Reactome:448733 "PI3K/AKT signalling"
xref: Reactome:469855 "PI3K/AKT signalling"
xref: Reactome:487549 "PI3K/AKT signalling"
xref: Reactome:507505 "PI3K/AKT signalling"
xref: Reactome:517533 "PI3K/AKT signalling"
xref: Reactome:526399 "PI3K/AKT signalling"
xref: Reactome:531215 "PI3K/AKT signalling"
xref: Reactome:536585 "PI3K/AKT signalling"
xref: Reactome:542311 "PI3K/AKT signalling"
xref: Reactome:547651 "PI3K/AKT signalling"
xref: Reactome:557860 "PI3K/AKT signalling"
xref: Reactome:568453 "PI3K/AKT signalling"
xref: Reactome:581666 "PI3K/AKT signalling"
xref: Reactome:585817 "PI3K/AKT signalling"
xref: Reactome:592575 "PI3K/AKT signalling"
xref: Reactome:595390 "PI3K/AKT signalling"
is_a: GO:0019932 ! second-messenger-mediated signaling

[Term]
id: GO:0048016
name: inositol phosphate-mediated signaling
namespace: biological_process
def: "A series of molecular signals in which a cell uses a water-soluble inositol phosphate to convert an extracellular signal into a response." [GOC:ceb]
synonym: "inositol phosphate-mediated signalling" EXACT []
synonym: "inositol phospholipid-mediated signaling" BROAD []
is_a: GO:0048015 ! phosphoinositide-mediated signaling

[Term]
id: GO:0048017
name: inositol lipid-mediated signaling
namespace: biological_process
def: "A series of molecular signals in which a cell uses an inositol lipid to convert an extracellular signal into a response." [GOC:ceb, PMID:11331907]
synonym: "inositol lipid-mediated signalling" EXACT []
synonym: "inositol phospholipid-mediated signaling" BROAD []
is_a: GO:0048015 ! phosphoinositide-mediated signaling

[Term]
id: GO:0048018
name: receptor agonist activity
namespace: molecular_function
def: "Interacts with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0005102 ! receptor binding
is_a: GO:0030546 ! receptor activator activity

[Term]
id: GO:0048019
name: receptor antagonist activity
namespace: molecular_function
def: "Interacts with receptors to reduce the action of another ligand, the agonist." [GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0005102 ! receptor binding
is_a: GO:0030547 ! receptor inhibitor activity

[Term]
id: GO:0048020
name: CCR chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CCR chemokine receptor." [GOC:ai]
synonym: "beta chemokine receptor binding" EXACT []
synonym: "beta chemokine receptor ligand" NARROW []
synonym: "CCR chemokine receptor ligand" NARROW []
is_a: GO:0042379 ! chemokine receptor binding

[Term]
id: GO:0048021
name: regulation of melanin biosynthetic process
namespace: biological_process
def: "Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jic]
subset: gosubset_prok
synonym: "regulation of melanin anabolism" EXACT []
synonym: "regulation of melanin biosynthesis" EXACT []
synonym: "regulation of melanin formation" EXACT []
synonym: "regulation of melanin synthesis" EXACT []
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0043455 ! regulation of secondary metabolic process
relationship: regulates GO:0042438 ! melanin biosynthetic process

[Term]
id: GO:0048022
name: negative regulation of melanin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jic]
subset: gosubset_prok
synonym: "down regulation of melanin biosynthetic process" EXACT []
synonym: "down-regulation of melanin biosynthetic process" EXACT []
synonym: "downregulation of melanin biosynthetic process" EXACT []
synonym: "inhibition of melanin biosynthetic process" NARROW []
synonym: "negative regulation of melanin anabolism" EXACT []
synonym: "negative regulation of melanin biosynthesis" EXACT []
synonym: "negative regulation of melanin formation" EXACT []
synonym: "negative regulation of melanin synthesis" EXACT []
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0048021 ! regulation of melanin biosynthetic process
relationship: negatively_regulates GO:0042438 ! melanin biosynthetic process

[Term]
id: GO:0048023
name: positive regulation of melanin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jic]
subset: gosubset_prok
synonym: "activation of melanin biosynthetic process" NARROW []
synonym: "positive regulation of melanin anabolism" EXACT []
synonym: "positive regulation of melanin biosynthesis" EXACT []
synonym: "positive regulation of melanin formation" EXACT []
synonym: "positive regulation of melanin synthesis" EXACT []
synonym: "stimulation of melanin biosynthetic process" NARROW []
synonym: "up regulation of melanin biosynthetic process" EXACT []
synonym: "up-regulation of melanin biosynthetic process" EXACT []
synonym: "upregulation of melanin biosynthetic process" EXACT []
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0048021 ! regulation of melanin biosynthetic process
relationship: positively_regulates GO:0042438 ! melanin biosynthetic process

[Term]
id: GO:0048024
name: regulation of nuclear mRNA splicing, via spliceosome
namespace: biological_process
alt_id: GO:0035055
def: "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jic]
synonym: "regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "regulation of pre-mRNA splicing" BROAD []
is_a: GO:0043484 ! regulation of RNA splicing
is_a: GO:0050684 ! regulation of mRNA processing
relationship: regulates GO:0000398 ! nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0048025
name: negative regulation of nuclear mRNA splicing, via spliceosome
namespace: biological_process
alt_id: GO:0035056
def: "Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jic]
synonym: "down regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "down regulation of nuclear mRNA splicing, via spliceosome" EXACT []
synonym: "down-regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "down-regulation of nuclear mRNA splicing, via spliceosome" EXACT []
synonym: "downregulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "downregulation of nuclear mRNA splicing, via spliceosome" EXACT []
synonym: "inhibition of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "inhibition of nuclear mRNA splicing, via spliceosome" NARROW []
synonym: "negative regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "negative regulation of pre-mRNA splicing" BROAD []
is_a: GO:0033119 ! negative regulation of RNA splicing
is_a: GO:0048024 ! regulation of nuclear mRNA splicing, via spliceosome
is_a: GO:0050686 ! negative regulation of mRNA processing
relationship: negatively_regulates GO:0000398 ! nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0048026
name: positive regulation of nuclear mRNA splicing, via spliceosome
namespace: biological_process
alt_id: GO:0035057
def: "Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jic]
synonym: "activation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "activation of nuclear mRNA splicing, via spliceosome" NARROW []
synonym: "positive regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "positive regulation of pre-mRNA splicing" BROAD []
synonym: "stimulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "stimulation of nuclear mRNA splicing, via spliceosome" NARROW []
synonym: "up regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "up regulation of nuclear mRNA splicing, via spliceosome" EXACT []
synonym: "up-regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "up-regulation of nuclear mRNA splicing, via spliceosome" EXACT []
synonym: "upregulation of nuclear mRNA splicing via U2-type spliceosome" NARROW []
synonym: "upregulation of nuclear mRNA splicing, via spliceosome" EXACT []
is_a: GO:0033120 ! positive regulation of RNA splicing
is_a: GO:0048024 ! regulation of nuclear mRNA splicing, via spliceosome
is_a: GO:0050685 ! positive regulation of mRNA processing
relationship: positively_regulates GO:0000398 ! nuclear mRNA splicing, via spliceosome

[Term]
id: GO:0048027
name: mRNA 5'-UTR binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule." [GOC:jic]
subset: gosubset_prok
synonym: "mRNA 5' UTR binding" EXACT []
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:0048028
name: galacturonan binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any simple or complex galacturonan. Galacturonan is any glycan composed solely of galacturonic acid residues, a specific type of glycuronan, and a constituent of some pectins." [GOC:jic]
subset: gosubset_prok
synonym: "polygalacturonide binding" RELATED []
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0048029
name: monosaccharide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ChEBI:35381, GOC:jic]
subset: gosubset_prok
is_a: GO:0005529 ! sugar binding

[Term]
id: GO:0048030
name: disaccharide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any disaccharide. Disaccharides are sugars composed of two monosaccharide units." [GOC:jic]
is_a: GO:0005529 ! sugar binding

[Term]
id: GO:0048031
name: trisaccharide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any trisaccharide. Trisaccharides are sugars composed of three monosaccharide units." [GOC:jic]
is_a: GO:0005529 ! sugar binding

[Term]
id: GO:0048032
name: galacturonate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [ChEBI:33812, GOC:jic]
synonym: "galacturonic acid binding" EXACT []
is_a: GO:0043168 ! anion binding
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0048033
name: heme o metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jic]
subset: gosubset_prok
synonym: "haem o metabolic process" EXACT []
synonym: "haem o metabolism" EXACT []
synonym: "heme o metabolism" EXACT []
is_a: GO:0042168 ! heme metabolic process

[Term]
id: GO:0048034
name: heme O biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jic]
subset: gosubset_prok
synonym: "haem O biosynthesis" EXACT []
synonym: "haem O biosynthetic process" EXACT []
synonym: "heme O anabolism" EXACT []
synonym: "heme O biosynthesis" EXACT []
synonym: "heme O formation" EXACT []
synonym: "heme O synthesis" EXACT []
is_a: GO:0006783 ! heme biosynthetic process
is_a: GO:0048033 ! heme o metabolic process

[Term]
id: GO:0048035
name: heme o catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jic]
subset: gosubset_prok
synonym: "haem o catabolic process" EXACT []
synonym: "haem o catabolism" EXACT []
synonym: "heme o breakdown" EXACT []
synonym: "heme o catabolism" EXACT []
synonym: "heme o degradation" EXACT []
is_a: GO:0042167 ! heme catabolic process
is_a: GO:0048033 ! heme o metabolic process

[Term]
id: GO:0048036
name: central complex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252]
synonym: "central body development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0048037
name: cofactor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0048038
name: quinone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0048037 ! cofactor binding

[Term]
id: GO:0048039
name: ubiquinone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ubiquinone, a quinone derivative with a tail of isoprene units." [GOC:jic, ISBN:0582227089]
subset: gosubset_prok
synonym: "coenzyme Q binding" EXACT []
synonym: "coenzyme Q6 binding" NARROW []
is_a: GO:0048038 ! quinone binding

[Term]
id: GO:0048040
name: UDP-glucuronate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-glucuronic acid = UDP-D-xylose + CO2." [EC:4.1.1.35, PMID:11593010]
synonym: "UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)" EXACT [EC:4.1.1.35]
synonym: "UDP-D-glucuronate carboxy-lyase activity" EXACT [EC:4.1.1.35]
synonym: "UDP-glucuronic acid decarboxylase activity" EXACT []
synonym: "UDPglucuronate decarboxylase activity" EXACT [EC:4.1.1.35]
synonym: "uridine-diphosphoglucuronate decarboxylase activity" EXACT [EC:4.1.1.35]
xref: EC:4.1.1.35
xref: MetaCyc:UDP-GLUCURONATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0048041
name: focal adhesion assembly
namespace: biological_process
def: "The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity." [GOC:jic, GOC:mah]
synonym: "focal adhesion formation" RELATED [GOC:mah]
is_a: GO:0007044 ! cell-substrate junction assembly
relationship: part_of GO:0007160 ! cell-matrix adhesion

[Term]
id: GO:0048042
name: regulation of post-mating oviposition
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb, PMID:11932766]
synonym: "regulation of oviposition, post-mating" EXACT [GOC:dph, GOC:tb]
is_a: GO:0046662 ! regulation of oviposition
relationship: regulates GO:0060403 ! post-mating oviposition

[Term]
id: GO:0048045
name: trans-pentaprenyltranstransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-pentaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-hexaprenyl diphosphate." [EC:2.5.1.33]
subset: gosubset_prok
synonym: "all-trans-hexaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.33]
synonym: "all-trans-pentaprenyl-diphosphate:isopentenyl-diphosphate pentaprenyltranstransferase activity" EXACT [EC:2.5.1.33]
synonym: "hexaprenyl diphosphate synthase activity" EXACT [EC:2.5.1.33]
synonym: "hexaprenyl pyrophosphate synthetase activity" EXACT []
xref: EC:2.5.1.33
xref: MetaCyc:TRANS-PENTAPRENYLTRANSFERASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0048046
name: apoplast
namespace: cellular_component
def: "The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it." [GOC:jic]
xref: Wikipedia:Apoplast
is_a: GO:0005576 ! extracellular region

[Term]
id: GO:0048047
name: mating behavior, sex discrimination
namespace: biological_process
def: "The actions or reactions of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jic, PMID:12486700]
synonym: "mating behaviour, sex discrimination" EXACT []
is_a: GO:0007617 ! mating behavior

[Term]
id: GO:0048048
name: embryonic eye morphogenesis
namespace: biological_process
def: "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic]
is_a: GO:0048562 ! embryonic organ morphogenesis
is_a: GO:0048592 ! eye morphogenesis

[Term]
id: GO:0048050
name: post-embryonic eye morphogenesis
namespace: biological_process
alt_id: GO:0048051
def: "The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. Morphogenesis pertains to the creation of form. The eye is the organ of sight." [GOC:jic, GOC:sensu]
is_a: GO:0048563 ! post-embryonic organ morphogenesis
is_a: GO:0048592 ! eye morphogenesis

[Term]
id: GO:0048052
name: R1/R6 cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jic]
is_a: GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0048053
name: R1/R6 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the R1 and R6 pair of photoreceptors in the eye over time, from their formation to the mature structures. R1 and R6 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jic]
is_a: GO:0042051 ! compound eye photoreceptor development
relationship: part_of GO:0048052 ! R1/R6 cell differentiation

[Term]
id: GO:0048054
name: R2/R5 cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire the specialized features of R2 and R5 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jic]
is_a: GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0048055
name: R2/R5 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the R2 and R5 pair of photoreceptors in the eye over time, from their formation to the mature structures. R2 and R5 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jic]
is_a: GO:0042051 ! compound eye photoreceptor development
relationship: part_of GO:0048054 ! R2/R5 cell differentiation

[Term]
id: GO:0048056
name: R3/R4 cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire the specialized features of R3 and R4 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jic]
is_a: GO:0001751 ! compound eye photoreceptor cell differentiation

[Term]
id: GO:0048057
name: R3/R4 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the R3 and R4 pair of photoreceptors in the eye over time, from their formation to the mature structures. R3 and R4 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jic]
is_a: GO:0042051 ! compound eye photoreceptor development
relationship: part_of GO:0048056 ! R3/R4 cell differentiation

[Term]
id: GO:0048058
name: compound eye corneal lens development
namespace: biological_process
def: "The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells." [GOC:jic]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048749 ! compound eye development

[Term]
id: GO:0048060
name: negative gravitaxis
namespace: biological_process
alt_id: GO:0048063
def: "The directed movement of a motile cell or organism away from the source of gravity." [GOC:jic]
synonym: "negative geotactic behavior" EXACT []
synonym: "negative geotactic behaviour" EXACT []
synonym: "negative gravitactic behavior" EXACT []
synonym: "negative gravitactic behaviour" EXACT []
synonym: "negative taxis in response to gravity" EXACT []
synonym: "negative taxis in response to gravitytaxis in response to gravitational stimulus" EXACT []
is_a: GO:0042332 ! gravitaxis

[Term]
id: GO:0048061
name: positive gravitaxis
namespace: biological_process
alt_id: GO:0048064
def: "The directed movement of a motile cell or organism towards the source of gravity." [GOC:jic]
synonym: "positive geotactic behavior" EXACT []
synonym: "positive geotactic behaviour" EXACT []
synonym: "positive gravitactic behavior" EXACT []
synonym: "positive gravitactic behaviour" EXACT []
synonym: "positive taxis in response to gravity" EXACT []
synonym: "positive taxis in response to gravitytaxis in response to gravitational stimulus" EXACT []
is_a: GO:0042332 ! gravitaxis

[Term]
id: GO:0048065
name: male courtship behavior, veined wing extension
namespace: biological_process
def: "The process during courtship where the male insect extends his wings. An example of this process is found in Drosophila melanogaster." [GOC:jic, GOC:mtg_sensu]
synonym: "male courtship behavior, wing extension" BROAD []
synonym: "male courtship behaviour, veined wing extension" EXACT []
synonym: "male courtship behaviour, wing extension" BROAD []
is_a: GO:0008049 ! male courtship behavior

[Term]
id: GO:0048066
name: pigmentation during development
namespace: biological_process
def: "The deposition of coloring matter in an organism, tissue or cell, occurring during development." [ISBN:0582227089]
subset: gosubset_prok
synonym: "developmental pigmentation" EXACT []
is_a: GO:0032502 ! developmental process
is_a: GO:0043473 ! pigmentation

[Term]
id: GO:0048067
name: cuticle pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jic]
is_a: GO:0048066 ! pigmentation during development
relationship: part_of GO:0042335 ! cuticle development

[Term]
id: GO:0048069
name: eye pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in the eye of an organism." [GOC:jic]
xref: Wikipedia:Eye_color
is_a: GO:0048066 ! pigmentation during development

[Term]
id: GO:0048070
name: regulation of pigmentation during development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the deposition of coloring matter occurring during development." [GOC:jic, GOC:tb]
synonym: "regulation of developmental pigmentation" EXACT [GOC:tb]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0048066 ! pigmentation during development

[Term]
id: GO:0048071
name: sex-specific pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in one sex that is not observed in the other sex." [GOC:jic]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048066 ! pigmentation during development
relationship: part_of GO:0007548 ! sex differentiation

[Term]
id: GO:0048072
name: compound eye pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in the compound eye." [GOC:jic]
is_a: GO:0048069 ! eye pigmentation

[Term]
id: GO:0048073
name: regulation of eye pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jic]
is_a: GO:0048070 ! regulation of pigmentation during development
relationship: regulates GO:0048069 ! eye pigmentation

[Term]
id: GO:0048074
name: negative regulation of eye pigmentation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jic]
synonym: "down regulation of eye pigmentation" EXACT []
synonym: "down-regulation of eye pigmentation" EXACT []
synonym: "downregulation of eye pigmentation" EXACT []
synonym: "inhibition of eye pigmentation" NARROW []
is_a: GO:0048073 ! regulation of eye pigmentation
is_a: GO:0048086 ! negative regulation of pigmentation during development
relationship: negatively_regulates GO:0048069 ! eye pigmentation

[Term]
id: GO:0048075
name: positive regulation of eye pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jic]
synonym: "activation of eye pigmentation" NARROW []
synonym: "stimulation of eye pigmentation" NARROW []
synonym: "up regulation of eye pigmentation" EXACT []
synonym: "up-regulation of eye pigmentation" EXACT []
synonym: "upregulation of eye pigmentation" EXACT []
is_a: GO:0048073 ! regulation of eye pigmentation
is_a: GO:0048087 ! positive regulation of pigmentation during development
relationship: positively_regulates GO:0048069 ! eye pigmentation

[Term]
id: GO:0048076
name: regulation of compound eye pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jic]
is_a: GO:0048073 ! regulation of eye pigmentation
relationship: regulates GO:0048072 ! compound eye pigmentation

[Term]
id: GO:0048077
name: negative regulation of compound eye pigmentation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jic]
synonym: "down regulation of eye pigmentation" BROAD []
synonym: "down-regulation of eye pigmentation" BROAD []
synonym: "downregulation of eye pigmentation" BROAD []
synonym: "inhibition of eye pigmentation" BROAD []
synonym: "negative regulation of eye pigmentation" BROAD []
is_a: GO:0048074 ! negative regulation of eye pigmentation
is_a: GO:0048076 ! regulation of compound eye pigmentation
relationship: negatively_regulates GO:0048072 ! compound eye pigmentation

[Term]
id: GO:0048078
name: positive regulation of compound eye pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jic]
synonym: "activation of eye pigmentation" BROAD []
synonym: "positive regulation of eye pigmentation" BROAD []
synonym: "stimulation of eye pigmentation" BROAD []
synonym: "up regulation of eye pigmentation" BROAD []
synonym: "up-regulation of eye pigmentation" BROAD []
synonym: "upregulation of eye pigmentation" BROAD []
is_a: GO:0048075 ! positive regulation of eye pigmentation
is_a: GO:0048076 ! regulation of compound eye pigmentation
relationship: positively_regulates GO:0048072 ! compound eye pigmentation

[Term]
id: GO:0048079
name: regulation of cuticle pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jic]
is_a: GO:0048070 ! regulation of pigmentation during development
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0048067 ! cuticle pigmentation

[Term]
id: GO:0048080
name: negative regulation of cuticle pigmentation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jic]
synonym: "down regulation of cuticle pigmentation" EXACT []
synonym: "down-regulation of cuticle pigmentation" EXACT []
synonym: "downregulation of cuticle pigmentation" EXACT []
synonym: "inhibition of cuticle pigmentation" NARROW []
is_a: GO:0048079 ! regulation of cuticle pigmentation
is_a: GO:0048086 ! negative regulation of pigmentation during development
relationship: negatively_regulates GO:0048067 ! cuticle pigmentation

[Term]
id: GO:0048081
name: positive regulation of cuticle pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jic]
synonym: "activation of cuticle pigmentation" NARROW []
synonym: "stimulation of cuticle pigmentation" NARROW []
synonym: "up regulation of cuticle pigmentation" EXACT []
synonym: "up-regulation of cuticle pigmentation" EXACT []
synonym: "upregulation of cuticle pigmentation" EXACT []
is_a: GO:0048079 ! regulation of cuticle pigmentation
is_a: GO:0048087 ! positive regulation of pigmentation during development
relationship: positively_regulates GO:0048067 ! cuticle pigmentation

[Term]
id: GO:0048082
name: regulation of adult chitin-containing cuticle pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jic, GOC:mtg_sensu]
is_a: GO:0007564 ! regulation of chitin-based cuticle tanning
is_a: GO:0048079 ! regulation of cuticle pigmentation
relationship: regulates GO:0048085 ! adult chitin-containing cuticle pigmentation

[Term]
id: GO:0048083
name: negative regulation of adult chitin-containing cuticle pigmentation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jic, GOC:mtg_sensu]
synonym: "down regulation of adult chitin-containing cuticle pigmentation" EXACT []
synonym: "down-regulation of adult chitin-containing cuticle pigmentation" EXACT []
synonym: "downregulation of adult chitin-containing cuticle pigmentation" EXACT []
synonym: "inhibition of adult chitin-containing cuticle pigmentation" NARROW []
is_a: GO:0048080 ! negative regulation of cuticle pigmentation
is_a: GO:0048082 ! regulation of adult chitin-containing cuticle pigmentation
relationship: negatively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation

[Term]
id: GO:0048084
name: positive regulation of adult chitin-containing cuticle pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jic, GOC:mtg_sensu]
synonym: "activation of adult chitin-containing cuticle pigmentation" NARROW []
synonym: "stimulation of adult chitin-containing cuticle pigmentation" NARROW []
synonym: "up regulation of adult chitin-containing cuticle pigmentation" EXACT []
synonym: "up-regulation of adult chitin-containing cuticle pigmentation" EXACT []
synonym: "upregulation of adult chitin-containing cuticle pigmentation" EXACT []
is_a: GO:0048081 ! positive regulation of cuticle pigmentation
is_a: GO:0048082 ! regulation of adult chitin-containing cuticle pigmentation
relationship: positively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation

[Term]
id: GO:0048085
name: adult chitin-containing cuticle pigmentation
namespace: biological_process
alt_id: GO:0048068
def: "Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster." [GOC:jic, GOC:mtg_sensu]
synonym: "adult cuticle pigmentation" BROAD []
is_a: GO:0048067 ! cuticle pigmentation
relationship: part_of GO:0007593 ! chitin-based cuticle tanning

[Term]
id: GO:0048086
name: negative regulation of pigmentation during development
namespace: biological_process
def: "Any process that stops, prevents or reduces the deposition of coloring matter occurring during development." [GOC:dph, GOC:jic, GOC:tb]
synonym: "down regulation of pigmentation" EXACT []
synonym: "down-regulation of pigmentation" EXACT []
synonym: "downregulation of pigmentation" EXACT []
synonym: "inhibition of pigmentation" NARROW []
is_a: GO:0048070 ! regulation of pigmentation during development
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0048066 ! pigmentation during development

[Term]
id: GO:0048087
name: positive regulation of pigmentation during development
namespace: biological_process
def: "Any process that activates or increases the deposition of coloring matter occurring during development." [GOC:dph, GOC:jic, GOC:tb]
synonym: "activation of pigmentation" NARROW []
synonym: "stimulation of pigmentation" NARROW []
synonym: "up regulation of pigmentation" EXACT []
synonym: "up-regulation of pigmentation" EXACT []
synonym: "upregulation of pigmentation" EXACT []
is_a: GO:0048070 ! regulation of pigmentation during development
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0048066 ! pigmentation during development

[Term]
id: GO:0048088
name: regulation of male pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jic]
is_a: GO:0048070 ! regulation of pigmentation during development
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0048094 ! male pigmentation

[Term]
id: GO:0048089
name: regulation of female pigmentation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jic]
is_a: GO:0048070 ! regulation of pigmentation during development
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0048095 ! female pigmentation

[Term]
id: GO:0048090
name: negative regulation of female pigmentation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jic]
synonym: "down regulation of female pigmentation" EXACT []
synonym: "down-regulation of female pigmentation" EXACT []
synonym: "downregulation of female pigmentation" EXACT []
synonym: "inhibition of female pigmentation" NARROW []
is_a: GO:0048086 ! negative regulation of pigmentation during development
is_a: GO:0048089 ! regulation of female pigmentation
relationship: negatively_regulates GO:0048095 ! female pigmentation

[Term]
id: GO:0048091
name: positive regulation of female pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jic]
synonym: "activation of female pigmentation" NARROW []
synonym: "stimulation of female pigmentation" NARROW []
synonym: "up regulation of female pigmentation" EXACT []
synonym: "up-regulation of female pigmentation" EXACT []
synonym: "upregulation of female pigmentation" EXACT []
is_a: GO:0048087 ! positive regulation of pigmentation during development
is_a: GO:0048089 ! regulation of female pigmentation
relationship: positively_regulates GO:0048095 ! female pigmentation

[Term]
id: GO:0048092
name: negative regulation of male pigmentation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jic]
synonym: "down regulation of male pigmentation" EXACT []
synonym: "down-regulation of male pigmentation" EXACT []
synonym: "downregulation of male pigmentation" EXACT []
synonym: "inhibition of male pigmentation" NARROW []
is_a: GO:0048086 ! negative regulation of pigmentation during development
is_a: GO:0048088 ! regulation of male pigmentation
relationship: negatively_regulates GO:0048094 ! male pigmentation

[Term]
id: GO:0048093
name: positive regulation of male pigmentation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jic]
synonym: "activation of male pigmentation" NARROW []
synonym: "stimulation of male pigmentation" NARROW []
synonym: "up regulation of male pigmentation" EXACT []
synonym: "up-regulation of male pigmentation" EXACT []
synonym: "upregulation of male pigmentation" EXACT []
is_a: GO:0048087 ! positive regulation of pigmentation during development
is_a: GO:0048088 ! regulation of male pigmentation
relationship: positively_regulates GO:0048094 ! male pigmentation

[Term]
id: GO:0048094
name: male pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in males." [GOC:jic]
is_a: GO:0048071 ! sex-specific pigmentation
relationship: part_of GO:0046661 ! male sex differentiation

[Term]
id: GO:0048095
name: female pigmentation
namespace: biological_process
def: "Establishment of a pattern of pigment in females." [GOC:jic]
is_a: GO:0048071 ! sex-specific pigmentation
relationship: part_of GO:0046660 ! female sex differentiation

[Term]
id: GO:0048096
name: chromatin-mediated maintenance of transcription
namespace: biological_process
def: "Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable." [GOC:jic]
comment: Note that this process is the opposite of chromatin silencing. This regulation is exemplified by members of the trithorax group, which maintain the active state of homeotic gene transcription.
is_a: GO:0006338 ! chromatin remodeling
is_a: GO:0045815 ! positive regulation of gene expression, epigenetic
is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent

[Term]
id: GO:0048097
name: long-term maintenance of gene activation
namespace: biological_process
def: "Any mechanism, at the level of transcription or post-transcription, maintaining gene activation in the long-term." [GOC:jic]
comment: Note that this process is the opposite of gene silencing.
is_a: GO:0045815 ! positive regulation of gene expression, epigenetic

[Term]
id: GO:0048098
name: antennal joint development
namespace: biological_process
def: "The process whose specific outcome is the progression of the antennal joint over time, from its formation to the mature structure. The antennal joint is the joint between antennal segments." [GOC:jic]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007469 ! antennal development

[Term]
id: GO:0048099
name: anterior/posterior lineage restriction, imaginal disc
namespace: biological_process
def: "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:jic, PMID:10625531, PMID:9374402]
is_a: GO:0035161 ! imaginal disc lineage restriction
relationship: part_of GO:0007448 ! anterior/posterior pattern formation, imaginal disc

[Term]
id: GO:0048100
name: wing disc anterior/posterior pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing." [GOC:jic, PMID:10625531]
is_a: GO:0007448 ! anterior/posterior pattern formation, imaginal disc
is_a: GO:0035222 ! wing disc pattern formation

[Term]
id: GO:0048101
name: calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. The reaction is calmodulin and calcium-sensitive." [GOC:jic]
synonym: "calcium- and calmodulin-regulated cGMP phosphodiesterase activity" RELATED []
synonym: "calcium- and calmodulin-regulated cGMP-specific phosphodiesterase activity" EXACT []
synonym: "calcium- and calmodulin-regulated cyclic-GMP phosphodiesterase activity" EXACT []
synonym: "calcium/calmodulin-regulated cGMP-specific phosphodiesterase activity" EXACT []
is_a: GO:0047555 ! 3',5'-cyclic-GMP phosphodiesterase activity

[Term]
id: GO:0048102
name: autophagic cell death
namespace: biological_process
def: "A form of programmed cell death that is accompanied by macroautophagy, which is characterized by the sequestration of cytoplasmic material within autophagosomes for bulk degradation by lysosomes. Autophagic cell death is characterized by lack of chromatin condensation, massive vacuolization of the cytoplasm, and accumulation of (double-membraned) autophagic vacuoles, with little or no uptake by phagocytic cells." [GOC:mah, PMID:18846107]
synonym: "autophagic death" BROAD []
synonym: "programmed cell death by autophagy" EXACT []
synonym: "type II programmed cell death" RELATED [GOC:sl]
is_a: GO:0012501 ! programmed cell death

[Term]
id: GO:0048103
name: somatic stem cell division
namespace: biological_process
def: "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jic, ISBN:0582227089]
synonym: "somatic stem cell renewal" EXACT []
is_a: GO:0017145 ! stem cell division

[Term]
id: GO:0048104
name: establishment of body hair or bristle planar orientation
namespace: biological_process
def: "Orientation of hairs or sensory bristles that cover the body surface of an adult, such that they all point in a uniform direction along the plane of the epithelium from which they project." [GOC:ascb_2009, GOC:dph, GOC:jic, GOC:tb]
is_a: GO:0001736 ! establishment of planar polarity

[Term]
id: GO:0048105
name: establishment of body hair planar orientation
namespace: biological_process
def: "Orientation of body hairs, projections from the surface of an organism, such that the hairs all point in a uniform direction along the surface." [GOC:ascb_2009, GOC:dph, GOC:jic, GOC:tb]
is_a: GO:0048104 ! establishment of body hair or bristle planar orientation

[Term]
id: GO:0048106
name: establishment of body bristle planar orientation
namespace: biological_process
def: "Orientation along the body surface of bristles, sensory organs originating from a sensory organ precursor cell, such that they all point in a uniform direction." [GOC:ascb_2009, GOC:dph, GOC:jic, GOC:tb]
is_a: GO:0048104 ! establishment of body hair or bristle planar orientation
relationship: part_of GO:0008407 ! bristle morphogenesis

[Term]
id: GO:0048107
name: 4-amino-3-isothiazolidinone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 4-amino-3-isothiazolinone, five-membered saturated heterocyclic ring structures containing a sulfur and a nitrogen in the 1-position and 2-positions respectively." [GOC:jic]
subset: gosubset_prok
synonym: "4-amino-3-isothiazolidinone anabolism" EXACT []
synonym: "4-amino-3-isothiazolidinone biosynthesis" EXACT []
synonym: "4-amino-3-isothiazolidinone formation" EXACT []
synonym: "4-amino-3-isothiazolidinone synthesis" EXACT []
is_a: GO:0018130 ! heterocycle biosynthetic process

[Term]
id: GO:0048108
name: peptide cross-linking via 4-amino-3-isothiazolidinone
namespace: biological_process
def: "The formation of 4-amino-3-isothiazolinone cross-links by the formation of a sulfenylamide bond between cysteine or cysteine sulfenic acid, and the alpha-amido of the following residue." [GOC:jic, GOC:jsg]
comment: Note that this is a generic parent because the identity of the second amino acid is not critical for formation of the cross-link.
subset: gosubset_prok
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification

[Term]
id: GO:0048109
name: peptide cross-linking via 2-amino-3-isothiazolidinone-L-serine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link through a process of forming first an intermediate cysteine sulfenic acid by peroxide oxidation, followed by condensation with the alpha-amido of the following serine residue and the release of water." [GOC:jic, PMID:12802338, PMID:12802339, RESID:AA0344]
subset: gosubset_prok
xref: RESID:AA0344
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0048108 ! peptide cross-linking via 4-amino-3-isothiazolidinone

[Term]
id: GO:0048132
name: female germ-line stem cell division
namespace: biological_process
alt_id: GO:0048141
def: "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jic, GOC:mtg_sensu]
synonym: "female germ-line stem cell renewal" EXACT []
is_a: GO:0042078 ! germ-line stem cell division
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0048133
name: male germ-line stem cell division
namespace: biological_process
def: "The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes." [GOC:jic]
synonym: "male germ-line stem cell renewal" EXACT []
is_a: GO:0042078 ! germ-line stem cell division
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0048134
name: germ-line cyst formation
namespace: biological_process
def: "Formation of a cluster of germ-line cells derived from a single founder cell." [GOC:jic, PMID:10370240]
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0007281 ! germ cell development

[Term]
id: GO:0048135
name: female germ-line cyst formation
namespace: biological_process
def: "Formation of a cluster of germ-line cells, in the female gonad, derived from a single founder cell. An example of this process is found in Drosophila melanogaster." [GOC:jic]
is_a: GO:0048134 ! germ-line cyst formation
relationship: part_of GO:0048477 ! oogenesis

[Term]
id: GO:0048136
name: male germ-line cyst formation
namespace: biological_process
def: "Formation of a cluster of germ-line cells, in the male gonad of an insect, derived from a single founder cell (cystoblast)." [GOC:jic]
is_a: GO:0048134 ! germ-line cyst formation
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0048137
name: spermatocyte division
namespace: biological_process
def: "The meiotic divisions undergone by the primary and secondary spermatocytes to produce a cyst of haploid spermatids." [GOC:jic, ISBN:0879694238]
synonym: "spermatocyte cell division" EXACT []
is_a: GO:0051301 ! cell division
relationship: part_of GO:0048136 ! male germ-line cyst formation

[Term]
id: GO:0048138
name: germ-line cyst encapsulation
namespace: biological_process
def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst." [GOC:jic, PMID:11591336]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007276 ! gamete generation
relationship: part_of GO:0016333 ! morphogenesis of follicular epithelium

[Term]
id: GO:0048139
name: female germ-line cyst encapsulation
namespace: biological_process
def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the female gonad." [GOC:jic, PMID:11591336]
is_a: GO:0048138 ! germ-line cyst encapsulation
relationship: part_of GO:0007292 ! female gamete generation

[Term]
id: GO:0048140
name: male germ-line cyst encapsulation
namespace: biological_process
def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the male gonad." [GOC:jic, PMID:11591336]
is_a: GO:0048138 ! germ-line cyst encapsulation
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0048142
name: germarium-derived cystoblast division
namespace: biological_process
def: "The four rounds of incomplete mitosis undergone by a cystoblast derived from the germarium to form a 16-cell cyst. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster." [GOC:jic, GOC:mtg_sensu, PMID:11131529]
synonym: "cystoblast cell division" BROAD []
is_a: GO:0007282 ! cystoblast division
relationship: part_of GO:0030727 ! germarium-derived female germ-line cyst formation

[Term]
id: GO:0048143
name: astrocyte activation
namespace: biological_process
def: "A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10526094, PMID:10695728, PMID:12529254, PMID:12580336, PMID:9585813]
is_a: GO:0001775 ! cell activation
relationship: part_of GO:0014002 ! astrocyte development

[Term]
id: GO:0048144
name: fibroblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jic]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0048145
name: regulation of fibroblast proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jic]
is_a: GO:0042127 ! regulation of cell proliferation
relationship: regulates GO:0048144 ! fibroblast proliferation

[Term]
id: GO:0048146
name: positive regulation of fibroblast proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jic]
synonym: "activation of fibroblast proliferation" NARROW []
synonym: "stimulation of fibroblast proliferation" NARROW []
synonym: "up regulation of fibroblast proliferation" EXACT []
synonym: "up-regulation of fibroblast proliferation" EXACT []
synonym: "upregulation of fibroblast proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0048145 ! regulation of fibroblast proliferation
relationship: positively_regulates GO:0048144 ! fibroblast proliferation

[Term]
id: GO:0048147
name: negative regulation of fibroblast proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jic]
synonym: "down regulation of fibroblast proliferation" EXACT []
synonym: "down-regulation of fibroblast proliferation" EXACT []
synonym: "downregulation of fibroblast proliferation" EXACT []
synonym: "inhibition of fibroblast proliferation" NARROW []
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0048145 ! regulation of fibroblast proliferation
relationship: negatively_regulates GO:0048144 ! fibroblast proliferation

[Term]
id: GO:0048148
name: behavioral response to cocaine
namespace: biological_process
def: "A change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jic]
synonym: "behavioural response to cocaine" EXACT []
is_a: GO:0030534 ! adult behavior
is_a: GO:0042220 ! response to cocaine

[Term]
id: GO:0048149
name: behavioral response to ethanol
namespace: biological_process
def: "A change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jic]
synonym: "behavioural response to ethanol" EXACT []
is_a: GO:0030534 ! adult behavior
is_a: GO:0045471 ! response to ethanol

[Term]
id: GO:0048150
name: behavioral response to ether
namespace: biological_process
def: "A change in the behavior of an organism as a result of an ether stimulus." [GOC:jic]
synonym: "behavioural response to ether" EXACT []
is_a: GO:0030534 ! adult behavior
is_a: GO:0045472 ! response to ether

[Term]
id: GO:0048151
name: hyperphosphorylation
namespace: biological_process
def: "OBSOLETE. The excessive phosphorylation of a protein, as a result of activation of kinases, deactivation of phosphatases, or both." [GOC:jic, ISBN:039751820X, PMID:12859672]
comment: This term was made obsolete because it is an unnecessary grouping term and was poorly defined.
is_obsolete: true
replaced_by: GO:0016310

[Term]
id: GO:0048152
name: S100 beta biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of S100 beta protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jic]
synonym: "S100 beta anabolism" EXACT []
synonym: "S100 beta biosynthesis" EXACT []
synonym: "S100 beta formation" EXACT []
synonym: "S100 beta synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0048153
name: S100 alpha biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of S100 alpha protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jic]
synonym: "S100 alpha anabolism" EXACT []
synonym: "S100 alpha biosynthesis" EXACT []
synonym: "S100 alpha formation" EXACT []
synonym: "S100 alpha synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0048154
name: S100 beta binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with S100 beta protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jic]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0048155
name: S100 alpha binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with S100 alpha protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jic]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0048156
name: tau protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jic]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0048158
name: oogonium stage, oogenesis
namespace: biological_process
def: "The stage in mammalian oogenesis when the primordial germ cell is hardly distinguishable from other cortical cells of the ovary." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 1" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048159
name: primary oocyte stage, oogenesis
namespace: biological_process
def: "The stage in oogenesis when the oocyte has a nucleus slightly larger than those of the adjacent cells and is surrounded by a layer of loose squamous epithelial cells." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 2" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048160
name: primary follicle stage, oogenesis
namespace: biological_process
def: "The stage in oogenesis when a single layer of cuboidal follicle cells surrounds the oocyte. The oocyte nucleus is large." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 3" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048161
name: double layer follicle stage, oogenesis
namespace: biological_process
def: "The stage in oogenesis when a double layer of distinct follicle cells surrounds the oocyte. An example of this process is found in Mus musculus." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 4" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048162
name: multi-layer follicle stage, oogenesis
namespace: biological_process
def: "The stage in oogenesis when many layers of follicle cells surround the oocyte. There is a yolk nucleus (Balbiani's Body) near the germinal vesicle." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 5" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048163
name: scattered antral spaces stage, oogenesis
namespace: biological_process
def: "The stage in oogenesis when antral spaces begin to form in the follicle cells. Mitochondria form centers for yolk concentration." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 6" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048164
name: distinct antral spaces stage, oogenesis
namespace: biological_process
def: "The stage in oogenesis when the antral spaces become distinct and the first polar body forms." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 7" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048165
name: fused antrum stage, oogenesis
namespace: biological_process
def: "The stage in oogenesis when the antral spaces fuse to form a single antral space. The oocyte is suspended in the cumulus oophorous and the first polar body in the perivitelline space." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 8" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048166
name: mature follicle stage, oogenesis
namespace: biological_process
def: "The stage in oogenesis when the antrum is swollen with follicular fluid. The ovum is ready to erupt from the ovary and is arrested at metaphase of the second meiotic division." [GOC:jic, GOC:mtg_sensu, ISBN:0198542771]
synonym: "mammalian oogenesis stage 9" EXACT []
is_a: GO:0022605 ! oogenesis stage

[Term]
id: GO:0048167
name: regulation of synaptic plasticity
namespace: biological_process
def: "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jic, GOC:tb, http://www.mercksource.com, PMID:11891290]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0050804 ! regulation of synaptic transmission
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0048168
name: regulation of neuronal synaptic plasticity
namespace: biological_process
def: "A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:jic, http://www.mercksource.com, PMID:11891290]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0048167 ! regulation of synaptic plasticity

[Term]
id: GO:0048169
name: regulation of long-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jic, http://www.mercksource.com, PMID:11891290]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0048168 ! regulation of neuronal synaptic plasticity

[Term]
id: GO:0048170
name: positive regulation of long-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jic, http://www.mercksource.com, PMID:11891290]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
synonym: "activation of long-term neuronal synaptic plasticity" NARROW []
synonym: "stimulation of long-term neuronal synaptic plasticity" NARROW []
synonym: "up regulation of long-term neuronal synaptic plasticity" EXACT []
synonym: "up-regulation of long-term neuronal synaptic plasticity" EXACT []
synonym: "upregulation of long-term neuronal synaptic plasticity" EXACT []
is_a: GO:0048169 ! regulation of long-term neuronal synaptic plasticity
is_a: GO:0050769 ! positive regulation of neurogenesis

[Term]
id: GO:0048171
name: negative regulation of long-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that decreases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jic, http://www.mercksource.com, PMID:11891290]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
synonym: "down regulation of long-term neuronal synaptic plasticity" EXACT []
synonym: "down-regulation of long-term neuronal synaptic plasticity" EXACT []
synonym: "downregulation of long-term neuronal synaptic plasticity" EXACT []
synonym: "inhibition of long-term neuronal synaptic plasticity" NARROW []
is_a: GO:0048169 ! regulation of long-term neuronal synaptic plasticity
is_a: GO:0050768 ! negative regulation of neurogenesis

[Term]
id: GO:0048172
name: regulation of short-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jic, http://www.mercksource.com, PMID:11891290]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
is_a: GO:0048168 ! regulation of neuronal synaptic plasticity

[Term]
id: GO:0048173
name: positive regulation of short-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jic, http://www.mercksource.com, PMID:11891290]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
synonym: "activation of short-term neuronal synaptic plasticity" NARROW []
synonym: "stimulation of short-term neuronal synaptic plasticity" NARROW []
synonym: "up regulation of short-term neuronal synaptic plasticity" EXACT []
synonym: "up-regulation of short-term neuronal synaptic plasticity" EXACT []
synonym: "upregulation of short-term neuronal synaptic plasticity" EXACT []
is_a: GO:0048172 ! regulation of short-term neuronal synaptic plasticity
is_a: GO:0050769 ! positive regulation of neurogenesis

[Term]
id: GO:0048174
name: negative regulation of short-term neuronal synaptic plasticity
namespace: biological_process
def: "A process that decreases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jic, http://www.mercksource.com, PMID:11891290]
comment: Note that the syntax of the definition of the this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process.
synonym: "down regulation of short-term neuronal synaptic plasticity" EXACT []
synonym: "down-regulation of short-term neuronal synaptic plasticity" EXACT []
synonym: "downregulation of short-term neuronal synaptic plasticity" EXACT []
synonym: "inhibition of short-term neuronal synaptic plasticity" NARROW []
is_a: GO:0048172 ! regulation of short-term neuronal synaptic plasticity
is_a: GO:0050768 ! negative regulation of neurogenesis

[Term]
id: GO:0048175
name: hepatocyte growth factor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hepacyte growth factor. Hepatocyte growth factor is a mitogen for a number of cell types and it is found in liver cells and in many other cell types, including platelets." [GOC:jic, http://cancerweb.ncl.ac.uk]
synonym: "hepatocyte growth factor anabolism" EXACT []
synonym: "hepatocyte growth factor biosynthesis" EXACT []
synonym: "hepatocyte growth factor formation" EXACT []
synonym: "hepatocyte growth factor synthesis" EXACT []
synonym: "HGF biosynthesis" EXACT []
synonym: "HGF biosynthetic process" EXACT []
synonym: "scatter factor biosynthesis" EXACT []
synonym: "scatter factor biosynthetic process" EXACT []
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0032605 ! hepatocyte growth factor production

[Term]
id: GO:0048176
name: regulation of hepatocyte growth factor biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor." [GOC:jic, http://cancerweb.ncl.ac.uk]
synonym: "regulation of hepatocyte growth factor anabolism" EXACT []
synonym: "regulation of hepatocyte growth factor biosynthesis" EXACT []
synonym: "regulation of hepatocyte growth factor formation" EXACT []
synonym: "regulation of hepatocyte growth factor synthesis" EXACT []
synonym: "regulation of HGF biosynthesis" EXACT []
synonym: "regulation of HGF biosynthetic process" EXACT []
synonym: "regulation of scatter factor biosynthesis" EXACT []
synonym: "regulation of scatter factor biosynthetic process" EXACT []
is_a: GO:0032646 ! regulation of hepatocyte growth factor production
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
relationship: regulates GO:0048175 ! hepatocyte growth factor biosynthetic process

[Term]
id: GO:0048177
name: positive regulation of hepatocyte growth factor biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor." [GOC:jic, http://cancerweb.ncl.ac.uk]
synonym: "activation of hepatocyte growth factor biosynthetic process" NARROW []
synonym: "positive regulation of hepatocyte growth factor anabolism" EXACT []
synonym: "positive regulation of hepatocyte growth factor biosynthesis" EXACT []
synonym: "positive regulation of hepatocyte growth factor formation" EXACT []
synonym: "positive regulation of hepatocyte growth factor synthesis" EXACT []
synonym: "positive regulation of HGF biosynthesis" EXACT []
synonym: "positive regulation of HGF biosynthetic process" EXACT []
synonym: "positive regulation of scatter factor biosynthesis" EXACT []
synonym: "positive regulation of scatter factor biosynthetic process" EXACT []
synonym: "stimulation of hepatocyte growth factor biosynthetic process" NARROW []
synonym: "up regulation of hepatocyte growth factor biosynthetic process" EXACT []
synonym: "up-regulation of hepatocyte growth factor biosynthetic process" EXACT []
synonym: "upregulation of hepatocyte growth factor biosynthetic process" EXACT []
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0048176 ! regulation of hepatocyte growth factor biosynthetic process
relationship: positively_regulates GO:0048175 ! hepatocyte growth factor biosynthetic process

[Term]
id: GO:0048178
name: negative regulation of hepatocyte growth factor biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor." [GOC:jic, http://cancerweb.ncl.ac.uk]
synonym: "down regulation of hepatocyte growth factor biosynthetic process" EXACT []
synonym: "down-regulation of hepatocyte growth factor biosynthetic process" EXACT []
synonym: "downregulation of hepatocyte growth factor biosynthetic process" EXACT []
synonym: "inhibition of hepatocyte growth factor biosynthetic process" NARROW []
synonym: "negative regulation of hepatocyte growth factor anabolism" EXACT []
synonym: "negative regulation of hepatocyte growth factor biosynthesis" EXACT []
synonym: "negative regulation of hepatocyte growth factor formation" EXACT []
synonym: "negative regulation of hepatocyte growth factor synthesis" EXACT []
synonym: "negative regulation of HGF biosynthesis" EXACT []
synonym: "negative regulation of HGF biosynthetic process" EXACT []
synonym: "negative regulation of scatter factor biosynthesis" EXACT []
synonym: "negative regulation of scatter factor biosynthetic process" EXACT []
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0048176 ! regulation of hepatocyte growth factor biosynthetic process
relationship: negatively_regulates GO:0048175 ! hepatocyte growth factor biosynthetic process

[Term]
id: GO:0048179
name: activin receptor complex
namespace: cellular_component
def: "A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed." [PMID:8307945, PMID:8622651]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0048180
name: activin complex
namespace: cellular_component
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
subset: goslim_pir
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0048183
name: activin AB complex
namespace: cellular_component
def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B." [GOC:go_curators, http://www.mercksource.com, http://www.stedmans.com/]
comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'.
synonym: "inhibin beta-A" NARROW []
synonym: "inhibin beta-B" NARROW []
is_a: GO:0048180 ! activin complex

[Term]
id: GO:0048184
name: follistatin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the peptide hormone follistatin." [GOC:jic, GOC:mah]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0048185
name: activin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with activin, a dimer of inhibin-beta subunits." [GOC:jic, GOC:mah]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0048186
name: inhibin beta-A binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with inhibin beta-A." [GOC:jic]
is_a: GO:0034711 ! inhibin binding

[Term]
id: GO:0048187
name: inhibin beta-B binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with inhibin beta-B." [GOC:jic]
is_a: GO:0034711 ! inhibin binding

[Term]
id: GO:0048188
name: Set1C/COMPASS complex
namespace: cellular_component
def: "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447]
synonym: "COMPASS complex" EXACT [GOC:vw]
synonym: "Set1C" EXACT [GOC:vw]
is_a: GO:0016585 ! chromatin remodeling complex
is_a: GO:0035097 ! histone methyltransferase complex

[Term]
id: GO:0048189
name: Lid2 complex
namespace: cellular_component
def: "A protein complex that is thought to be involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid1p, Ash2p, Ecm5p, Snt2p, and Sdc1p." [PMID:12488447]
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0048190
name: wing disc dorsal/ventral pattern formation
namespace: biological_process
def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jic]
synonym: "wing disc dorsal-ventral pattern formation" EXACT [GOC:mah]
synonym: "wing disc dorsoventral pattern formation" EXACT [GOC:mah]
is_a: GO:0007450 ! dorsal/ventral pattern formation, imaginal disc
is_a: GO:0035222 ! wing disc pattern formation

[Term]
id: GO:0048191
name: peptide stabilization activity
namespace: molecular_function
def: "OBSOLETE. Strengthening of a bond between peptides. Peptides are compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jic]
comment: This term was made obsolete because it represents a biological process.
is_obsolete: true
replaced_by: GO:0050822

[Term]
id: GO:0048192
name: peptide antigen stabilization activity
namespace: molecular_function
def: "OBSOLETE. Strengthening of a bond with a peptide antigen; a fragment of a foreign protein derived by proteolysis within the cell." [GOC:jic]
comment: This term was made obsolete because it represents a biological process.
is_obsolete: true
replaced_by: GO:0050823

[Term]
id: GO:0048193
name: Golgi vesicle transport
namespace: biological_process
def: "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jic, ISBN:0716731363, PMID:10219233]
synonym: "Golgi-derived vesicle transport " RELATED []
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0048194
name: Golgi vesicle budding
namespace: biological_process
def: "The evagination of the Golgi membrane, resulting in formation of a vesicle." [GOC:jic, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle budding" NARROW []
synonym: "Golgi-derived vesicle budding" EXACT []
is_a: GO:0006900 ! membrane budding
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048195
name: Golgi membrane priming complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a membrane priming complex. An incoming coat component recognizes both GTPase and a membrane protein to form the priming complex." [GOC:jic, ISBN:0716731363, PMID:10219233]
synonym: "formation of dictyosome membrane priming complex" NARROW []
synonym: "formation of Golgi membrane priming complex" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0048200 ! Golgi transport vesicle coating

[Term]
id: GO:0048196
name: middle lamella-containing extracellular matrix
namespace: cellular_component
def: "The matrix external to the cell, composed of the cell wall and middle lamella." [GOC:jic, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk]
comment: Note that this term does not have 'extracellular region ; GO:0005576' as a parent because in plants the extracellular matrix is considered part of the cell.
subset: goslim_pir
is_a: GO:0030312 ! external encapsulating structure
is_a: GO:0031012 ! extracellular matrix

[Term]
id: GO:0048197
name: Golgi membrane coat protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of priming complexes to form a coat on a Golgi membrane. Priming complexes associate laterally and additional coat proteins are recruited from the cytosol to the forming coat. Cargo proteins diffuse into the budding site and become trapped by their interactions with the coat." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome membrane binding by cytosolic coat proteins" NARROW []
synonym: "dictyosome membrane bud coat oligomerisation" NARROW []
synonym: "Golgi membrane bud coat oligomerisation" NARROW []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0048200 ! Golgi transport vesicle coating

[Term]
id: GO:0048198
name: Golgi vesicle bud deformation and release
namespace: biological_process
def: "The process by which cytosolic coat proteins fit together in a basketlike convex framework to form a coated deformed region on the cytoplasmic surface of the membrane. The deformed region forms into a complete vesicle and is released." [GOC:jic, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle bud deformation" NARROW []
synonym: "Golgi-derived vesicle bud deformation and release" EXACT []
is_a: GO:0016044 ! cellular membrane organization
relationship: part_of GO:0048194 ! Golgi vesicle budding

[Term]
id: GO:0048199
name: vesicle targeting, to, from or within Golgi
namespace: biological_process
def: "The process by which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle targeting" NARROW []
synonym: "Golgi vesicle targeting" EXACT []
synonym: "vesicle targeting, to, from or within dictyosome" NARROW []
is_a: GO:0006903 ! vesicle targeting
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048200
name: Golgi transport vesicle coating
namespace: biological_process
def: "The addition of specific coat proteins to Golgi membranes during the formation of transport vesicles." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome transport vesicle coating" NARROW []
is_a: GO:0006901 ! vesicle coating
relationship: part_of GO:0048194 ! Golgi vesicle budding
relationship: part_of GO:0048199 ! vesicle targeting, to, from or within Golgi

[Term]
id: GO:0048201
name: vesicle targeting, plasma membrane to endosome
namespace: biological_process
def: "The process by which vesicles formed at the plasma membrane are directed to specific destinations in endosome membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "plasma membrane to endosome targeting" EXACT []
is_a: GO:0006903 ! vesicle targeting

[Term]
id: GO:0048202
name: clathrin coating of Golgi vesicle
namespace: biological_process
def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "clathrin coating of Golgi-derived vesicle" EXACT []
is_a: GO:0048200 ! Golgi transport vesicle coating
is_a: GO:0048268 ! clathrin coat assembly

[Term]
id: GO:0048203
name: vesicle targeting, trans-Golgi to endosome
namespace: biological_process
def: "The process by which vesicles are directed to specific destination membranes during transport from the trans-Golgi to the endosome." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "trans-Golgi to endosome targeting" EXACT []
is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi
relationship: part_of GO:0006895 ! Golgi to endosome transport

[Term]
id: GO:0048204
name: vesicle targeting, inter-Golgi cisterna
namespace: biological_process
def: "The process by which vesicles are directed to specific destination membranes during transport from one Golgi cisterna to another." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "inter-Golgi cisterna targeting" EXACT []
is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi
relationship: part_of GO:0048219 ! inter-Golgi cisterna vesicle-mediated transport

[Term]
id: GO:0048205
name: COPI coating of Golgi vesicle
namespace: biological_process
def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "COPI coating of Golgi-derived vesicle" EXACT []
xref: Reactome:199997 "COPI Mediated Transport"
xref: Reactome:448813 "COPI Mediated Transport"
xref: Reactome:469929 "COPI Mediated Transport"
xref: Reactome:487632 "COPI Mediated Transport"
xref: Reactome:507591 "COPI Mediated Transport"
xref: Reactome:517559 "COPI Mediated Transport"
xref: Reactome:526425 "COPI Mediated Transport"
xref: Reactome:531242 "COPI Mediated Transport"
xref: Reactome:536613 "COPI Mediated Transport"
xref: Reactome:542337 "COPI Mediated Transport"
xref: Reactome:547678 "COPI Mediated Transport"
xref: Reactome:552340 "COPI Mediated Transport"
xref: Reactome:557887 "COPI Mediated Transport"
xref: Reactome:568485 "COPI Mediated Transport"
xref: Reactome:581696 "COPI Mediated Transport"
xref: Reactome:585896 "COPI Mediated Transport"
xref: Reactome:592603 "COPI Mediated Transport"
xref: Reactome:595452 "COPI Mediated Transport"
is_a: GO:0048200 ! Golgi transport vesicle coating

[Term]
id: GO:0048206
name: vesicle targeting, cis-Golgi to rough ER
namespace: biological_process
def: "The process by which vesicles are directed to specific destination membranes during transport from the cis-Golgi to the rough ER." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "cis-Golgi to rough endoplasmic reticulum targeting" EXACT []
synonym: "cis-Golgi to rough ER targeting" EXACT []
synonym: "vesicle targeting, cis-Golgi to rough endoplasmic reticulum" EXACT []
is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi
is_a: GO:0048220 ! cis-Golgi to rough ER vesicle-mediated transport

[Term]
id: GO:0048207
name: vesicle targeting, rough ER to cis-Golgi
namespace: biological_process
def: "The process by which vesicles are directed to specific destination membranes during transport from the rough endoplasmic reticulum to the cis-Golgi." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "rough endoplasmic reticulum to cis-Golgi targeting" EXACT []
synonym: "rough ER to cis-Golgi targeting" EXACT []
synonym: "vesicle targeting, rough endoplasmic reticulum to cis-Golgi" EXACT []
is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi
relationship: part_of GO:0006888 ! ER to Golgi vesicle-mediated transport

[Term]
id: GO:0048208
name: COPII vesicle coating
namespace: biological_process
def: "The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jic, GOC:mah, GOC:tb, ISBN:0716731363, PMID:10219233]
synonym: "COPII coating of ER-derived vesicle" EXACT [GOC:tb]
synonym: "COPII vesicle coat assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "COPII vesicle coat formation" EXACT [GOC:ascb_2009, GOC:dph, GOC:jpark, GOC:tb]
xref: Reactome:204005 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:448949 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:470068 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:487761 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:507725 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:517657 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:526490 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:531305 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:536679 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:542412 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:547761 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:552332 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:557937 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:568564 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:581768 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:585886 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:592687 "COPII (Coat Protein 2) Mediated Vesicle Transport"
xref: Reactome:595444 "COPII (Coat Protein 2) Mediated Vesicle Transport"
is_a: GO:0006901 ! vesicle coating
relationship: part_of GO:0048207 ! vesicle targeting, rough ER to cis-Golgi
relationship: part_of GO:0090114 ! COPII-coated vesicle budding

[Term]
id: GO:0048209
name: regulation of vesicle targeting, to, from or within Golgi
namespace: biological_process
def: "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "regulation of Golgi vesicle targeting" EXACT []
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060627 ! regulation of vesicle-mediated transport
relationship: regulates GO:0048199 ! vesicle targeting, to, from or within Golgi

[Term]
id: GO:0048210
name: Golgi vesicle fusion to target membrane
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane." [GOC:jic, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle fusion to target membrane" NARROW []
synonym: "Golgi-derived vesicle fusion to target membrane" EXACT []
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048211
name: Golgi vesicle docking
namespace: biological_process
def: "The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane." [GOC:jic, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle docking to target membrane" NARROW []
synonym: "Golgi vesicle docking with target membrane" EXACT []
synonym: "Golgi vesicle to membrane docking" EXACT []
synonym: "Golgi-derived vesicle docking" EXACT []
is_a: GO:0048278 ! vesicle docking
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048212
name: Golgi vesicle uncoating
namespace: biological_process
def: "The process by which Golgi vesicle coat proteins are depolymerized, and released for reuse." [GOC:jic, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle coat depolymerization" NARROW []
synonym: "Golgi vesicle coat depolymerization" EXACT []
synonym: "Golgi vesicle coat protein depolymerization" EXACT []
synonym: "Golgi-derived vesicle uncoating" EXACT []
is_a: GO:0051261 ! protein depolymerization
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048213
name: Golgi vesicle prefusion complex stabilization
namespace: biological_process
def: "The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized." [GOC:jic, ISBN:0716731363, PMID:10219233]
synonym: "dictyosome vesicle prefusion complex stabilisation" NARROW []
synonym: "Golgi vesicle prefusion complex assembly" EXACT []
synonym: "Golgi-derived vesicle prefusion complex stabilization" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048214
name: regulation of Golgi vesicle fusion to target membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jic, ISBN:0716731363, PMID:10219233]
comment: Note that GTP-binding Rab proteins serve as regulators of vesicle targeting and fusion.
is_a: GO:0031338 ! regulation of vesicle fusion
is_a: GO:0032386 ! regulation of intracellular transport
relationship: regulates GO:0048210 ! Golgi vesicle fusion to target membrane

[Term]
id: GO:0048215
name: positive regulation of Golgi vesicle fusion to target membrane
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jic, ISBN:0716731363, PMID:10219233]
synonym: "activation of Golgi vesicle fusion to target membrane" NARROW []
synonym: "stimulation of Golgi vesicle fusion to target membrane" NARROW []
synonym: "up regulation of Golgi vesicle fusion to target membrane" EXACT []
synonym: "up-regulation of Golgi vesicle fusion to target membrane" EXACT []
synonym: "upregulation of Golgi vesicle fusion to target membrane" EXACT []
is_a: GO:0031340 ! positive regulation of vesicle fusion
is_a: GO:0048214 ! regulation of Golgi vesicle fusion to target membrane
relationship: positively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane

[Term]
id: GO:0048216
name: negative regulation of Golgi vesicle fusion to target membrane
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jic, ISBN:0716731363, PMID:10219233]
synonym: "down regulation of Golgi vesicle fusion to target membrane" EXACT []
synonym: "down-regulation of Golgi vesicle fusion to target membrane" EXACT []
synonym: "downregulation of Golgi vesicle fusion to target membrane" EXACT []
synonym: "inhibition of Golgi vesicle fusion to target membrane" NARROW []
is_a: GO:0031339 ! negative regulation of vesicle fusion
is_a: GO:0048214 ! regulation of Golgi vesicle fusion to target membrane
relationship: negatively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane

[Term]
id: GO:0048217
name: pectic matrix
namespace: cellular_component
def: "The gel-like pectin matrix consists of the interlinked acidic and neutral pectin networks that are further cross-linked by calcium bridges. Pectins consist largely of long chains of mostly galacturonic acid units (typically 1,4 linkages and sometimes methyl esters). Three major pectic polysaccharides (homogalacturonan, rhamnogalacturonan I and rhamnogalacturonan II) are thought to occur in all primary cell walls." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009530 ! primary cell wall
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048219
name: inter-Golgi cisterna vesicle-mediated transport
namespace: biological_process
def: "The directed movement of substances from one Golgi cisterna to another, mediated by small transport vesicles." [GOC:jic, GOC:mah, ISBN:0716731363, PMID:10219233]
synonym: "inter-Golgi cisterna transport" EXACT []
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048220
name: cis-Golgi to rough ER vesicle-mediated transport
namespace: biological_process
def: "The directed movement of substances from the Golgi apparatus to the rough endoplasmic reticulum, mediated by vesicles." [GOC:jic, ISBN:0716731363, PMID:10219233]
synonym: "cis-Golgi to rough endoplasmic reticulum transport" EXACT []
synonym: "cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport" EXACT []
synonym: "cis-Golgi to rough ER transport" EXACT []
is_a: GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0048222
name: glycoprotein network
namespace: cellular_component
def: "A network of glycoproteins; proteins with covalently attached sugar units, either bonded via the hydroxyl group of serine or threonine (O glycosylated) or through the amino terminal of asparagine (N glycosylated)." [GOC:jic, http://cancerweb.ncl.ac.uk]
synonym: "extensin" EXACT []
xref: Wikipedia:Extensin
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009530 ! primary cell wall

[Term]
id: GO:0048223
name: hemicellulose network
namespace: cellular_component
def: "Network composed of hemicelluloses; members of a class of plant cell wall polysaccharide that cannot be extracted from the wall by hot water or chelating agents, but can be extracted by aqueous alkali. Includes xylan, glucuronoxylan, arabinoxylan, arabinogalactan II, glucomannan, xyloglucan and galactomannan." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009530 ! primary cell wall
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048224
name: lignin network
namespace: cellular_component
def: "A network composed of lignin; a complex polymer of phenylpropanoid subunits, laid down in the walls of plant cells such as xylem vessels and sclerenchyma. It imparts considerable strength to the wall and also protects it against degradation by microorganisms. It is also laid down as a defence reaction against pathogenic attack, as part of the hypersensitive response of plants." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048225
name: suberin network
namespace: cellular_component
def: "Fatty substance, containing long chain fatty acids and fatty esters, found in the cell walls of cork cells (phellem) in higher plants. Renders the cell wall impervious to water." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048226
name: Casparian strip
namespace: cellular_component
def: "Region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material (analogous to tight junction between epithelial cells). Found particularly where root parenchymal cells secrete solutes into xylem vessels. The barrier is composed of suberin; a fatty substance, containing long chain fatty acids and fatty esters, also found in the cell walls of cork cells (phellem) in higher plants." [GOC:jic, http://cancerweb.ncl.ac.uk]
xref: Wikipedia:Casparian_strip
is_a: GO:0044420 ! extracellular matrix part
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009531 ! secondary cell wall

[Term]
id: GO:0048227
name: plasma membrane to endosome transport
namespace: biological_process
def: "Transport of a vesicle from the plasma membrane to the endosome." [GOC:jic]
is_a: GO:0006886 ! intracellular protein transport

[Term]
id: GO:0048228
name: actin cortical patch distribution
namespace: biological_process
def: "OBSOLETE. Any process that establishes the spatial arrangement of actin cortical patches. An actin cortical patch is a discrete actin-containing structure found at the plasma membrane in fungal cells." [GOC:jic]
comment: This term was made obsolete because its definition is very similar to that of its parent term, actin cortical patch localization (GO:0051666), but somewhat unclear, and not similar enough to merge the terms.
is_obsolete: true

[Term]
id: GO:0048229
name: gametophyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gametophyte over time, from its formation to the mature structure. The gametophyte is the gamete-producing individual or phase in the life cycle having alternation of generations. An example of this process is found in Arabidopsis thaliana." [GOC:jic, http://cancerweb.ncl.ac.uk]
synonym: "gametogenesis" BROAD []
is_a: GO:0007275 ! multicellular organismal development

[Term]
id: GO:0048232
name: male gamete generation
namespace: biological_process
def: "Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction." [GOC:dph, GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0007276 ! gamete generation

[Term]
id: GO:0048235
name: pollen sperm cell differentiation
namespace: biological_process
alt_id: GO:0048234
def: "The process whereby a relatively unspecialized cell acquires specialized features of a haploid sperm cell within the plant gametophyte." [GOC:jic, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk]
synonym: "male gamete generation" BROAD []
synonym: "male gametophyte sperm cell differentiation" EXACT []
synonym: "sperm cell differentiation" BROAD []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048232 ! male gamete generation
relationship: part_of GO:0055046 ! microgametogenesis

[Term]
id: GO:0048236
name: plant-type spore development
namespace: biological_process
def: "The process whose specific outcome is the progression of the spore over time, from its formation to the mature structure. The spore gives rise to gametophytes." [GOC:jic, http://www.m-w.com]
synonym: "plant spore development" EXACT []
is_a: GO:0048869 ! cellular developmental process
is_a: GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0048237
name: rough endoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the rough endoplasmic reticulum." [GOC:jic]
synonym: "RER lumen" EXACT []
synonym: "rough ER lumen" EXACT []
xref: NIF_Subcellular:sao1819509473
is_a: GO:0005788 ! endoplasmic reticulum lumen
relationship: part_of GO:0005791 ! rough endoplasmic reticulum

[Term]
id: GO:0048238
name: smooth endoplasmic reticulum lumen
namespace: cellular_component
def: "The volume enclosed by the membranes of the smooth endoplasmic reticulum." [GOC:jic]
synonym: "SER lumen" EXACT []
synonym: "smooth ER lumen" EXACT []
xref: NIF_Subcellular:sao927884761
is_a: GO:0005788 ! endoplasmic reticulum lumen
relationship: part_of GO:0005790 ! smooth endoplasmic reticulum

[Term]
id: GO:0048239
name: negative regulation of DNA recombination at telomere
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of genetic recombination within the telomere." [GOC:jic, PMID:9635193]
synonym: "down regulation of telomeric recombination at telomere" EXACT []
synonym: "down-regulation of telomeric recombination at telomere" EXACT []
synonym: "downregulation of telomeric recombination at telomere" EXACT []
synonym: "inhibition of telomeric recombination at telomere" NARROW []
synonym: "negative regulation of telomeric recombination at telomere" EXACT [GOC:tb]
synonym: "suppression of telomeric recombination at telomere" EXACT []
is_a: GO:0000722 ! telomere maintenance via recombination
is_a: GO:0045910 ! negative regulation of DNA recombination

[Term]
id: GO:0048240
name: sperm capacitation
namespace: biological_process
def: "A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jic, PMID:11820818]
is_a: GO:0048469 ! cell maturation
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0007286 ! spermatid development

[Term]
id: GO:0048241
name: epinephrine transport
namespace: biological_process
def: "The directed movement of epinephrine into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jic]
synonym: "adrenaline transport" EXACT []
is_a: GO:0009914 ! hormone transport
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0048242
name: epinephrine secretion
namespace: biological_process
def: "The regulated release of epinephrine by a cell or group of cells. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system." [GOC:ef, GOC:jic]
synonym: "adrenaline secretion" EXACT []
is_a: GO:0048241 ! epinephrine transport
is_a: GO:0050432 ! catecholamine secretion

[Term]
id: GO:0048243
name: norepinephrine secretion
namespace: biological_process
def: "The regulated release of norepinephrine by a cell or group of cells. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system." [GOC:ef, GOC:jic]
synonym: "noradrenaline secretion" EXACT []
is_a: GO:0015874 ! norepinephrine transport
is_a: GO:0050432 ! catecholamine secretion

[Term]
id: GO:0048244
name: phytanoyl-CoA dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phytanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyphytanoyl-CoA + succinate + CO2." [EC:1.14.11.18, GOC:jic]
synonym: "phytanoyl-CoA 2 oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.18]
synonym: "phytanoyl-CoA 2-hydroxylase activity" EXACT [EC:1.14.11.18]
synonym: "phytanoyl-CoA alpha-hydroxylase activity" EXACT [EC:1.14.11.18]
synonym: "phytanoyl-CoA hydroxylase activity" EXACT [EC:1.14.11.18]
synonym: "phytanoyl-CoA, 2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.11.18]
xref: EC:1.14.11.18
xref: MetaCyc:1.14.11.18-RXN
xref: Reactome:78983 "phytanoyl-CoA dioxygenase activity"
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0048245
name: eosinophil chemotaxis
namespace: biological_process
def: "The movement of an eosinophil in response to an external stimulus." [GOC:jic, PMID:11292027, PMID:12391252]
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0048246
name: macrophage chemotaxis
namespace: biological_process
def: "The movement of a macrophage in response to an external stimulus." [GOC:jic]
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0048247
name: lymphocyte chemotaxis
namespace: biological_process
def: "The directed movement of a lymphocyte in response to an external stimulus." [GOC:hjd, GOC:jic, PMID:12391252]
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0048248
name: CXCR3 chemokine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a the CXCR3 chemokine receptor." [GOC:jic, PMID:10556837]
is_a: GO:0045236 ! CXCR chemokine receptor binding

[Term]
id: GO:0048249
name: high affinity phosphate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of phosphate from one side of the membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jic, PMID:8709965]
is_a: GO:0015114 ! phosphate transmembrane transporter activity

[Term]
id: GO:0048250
name: mitochondrial iron ion transport
namespace: biological_process
def: "The directed movement of iron ions into, out of or within a mitochondrion." [GOC:jic, PMID:12006577]
synonym: "mitochondrial iron transport" EXACT []
is_a: GO:0006826 ! iron ion transport
is_a: GO:0006839 ! mitochondrial transport

[Term]
id: GO:0048251
name: elastic fiber assembly
namespace: biological_process
def: "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching." [GOC:jic, PMID:10841810, PMID:12615674]
synonym: "elastic fibre assembly" EXACT []
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0030198 ! extracellular matrix organization

[Term]
id: GO:0048252
name: lauric acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources." [GOC:jic, http://cancerweb.ncl.ac.uk]
subset: gosubset_prok
synonym: "lauric acid metabolism" EXACT []
synonym: "n-dodecanoic acid metabolic process" EXACT []
synonym: "n-dodecanoic acid metabolism" EXACT []
is_a: GO:0001676 ! long-chain fatty acid metabolic process

[Term]
id: GO:0048254
name: snoRNA localization
namespace: biological_process
def: "Any process by which small nucleolar RNA is transported to, or maintained in, a specific location." [ISBN:0716731363]
synonym: "establishment and maintenance of snoRNA localization" EXACT []
synonym: "small nucleolar RNA localization" EXACT []
is_a: GO:0006403 ! RNA localization

[Term]
id: GO:0048255
name: mRNA stabilization
namespace: biological_process
def: "Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jic]
subset: gosubset_prok
is_a: GO:0043488 ! regulation of mRNA stability
is_a: GO:0043489 ! RNA stabilization

[Term]
id: GO:0048256
name: flap endonuclease activity
namespace: molecular_function
def: "Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jic]
subset: gosubset_prok
xref: EC:3.1.-.-.
is_a: GO:0004520 ! endodeoxyribonuclease activity

[Term]
id: GO:0048257
name: 3'-flap endonuclease activity
namespace: molecular_function
def: "Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jic, PMID:10635319]
synonym: "3' flap endonuclease activity" EXACT []
is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters
is_a: GO:0048256 ! flap endonuclease activity

[Term]
id: GO:0048258
name: 3-ketoglucose-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose." [MetaCyc:KETOGLUCOSE-REDUCTASE-RXN]
xref: EC:1.1.1.-
xref: MetaCyc:KETOGLUCOSE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0048259
name: regulation of receptor-mediated endocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb]
synonym: "regulation of receptor mediated endocytosis" EXACT [GOC:tb]
is_a: GO:0030100 ! regulation of endocytosis
relationship: regulates GO:0006898 ! receptor-mediated endocytosis

[Term]
id: GO:0048260
name: positive regulation of receptor-mediated endocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb]
synonym: "activation of receptor mediated endocytosis" NARROW []
synonym: "positive regulation of receptor mediated endocytosis" EXACT [GOC:tb]
synonym: "stimulation of receptor mediated endocytosis" NARROW []
synonym: "up regulation of receptor mediated endocytosis" EXACT []
synonym: "up-regulation of receptor mediated endocytosis" EXACT []
synonym: "upregulation of receptor mediated endocytosis" EXACT []
is_a: GO:0045807 ! positive regulation of endocytosis
is_a: GO:0048259 ! regulation of receptor-mediated endocytosis
relationship: positively_regulates GO:0006898 ! receptor-mediated endocytosis

[Term]
id: GO:0048261
name: negative regulation of receptor-mediated endocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators]
synonym: "down regulation of receptor mediated endocytosis" EXACT []
synonym: "down-regulation of receptor mediated endocytosis" EXACT []
synonym: "downregulation of receptor mediated endocytosis" EXACT []
synonym: "inhibition of receptor mediated endocytosis" NARROW []
synonym: "negative regulation of receptor mediated endocytosis" EXACT []
is_a: GO:0045806 ! negative regulation of endocytosis
is_a: GO:0048259 ! regulation of receptor-mediated endocytosis
relationship: negatively_regulates GO:0006898 ! receptor-mediated endocytosis

[Term]
id: GO:0048262
name: determination of dorsal/ventral asymmetry
namespace: biological_process
def: "Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis." [GOC:jic, http://cancerweb.ncl.ac.uk]
synonym: "determination of adaxial/abaxial asymmetry" RELATED [GOC:dph, GOC:tb]
synonym: "determination of dorsal-ventral asymmetry" EXACT [GOC:mah]
synonym: "determination of dorsoventral asymmetry" EXACT [GOC:mah]
is_a: GO:0009855 ! determination of bilateral symmetry
relationship: part_of GO:0009953 ! dorsal/ventral pattern formation

[Term]
id: GO:0048263
name: determination of dorsal identity
namespace: biological_process
def: "Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:jic]
synonym: "determination of adaxial identity" RELATED [GOC:dph, GOC:tb]
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0048262 ! determination of dorsal/ventral asymmetry

[Term]
id: GO:0048264
name: determination of ventral identity
namespace: biological_process
def: "The regionalization process by which the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:dph, GOC:isa_complete, GOC:jic]
synonym: "determination of abaxial identity" EXACT []
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0048262 ! determination of dorsal/ventral asymmetry

[Term]
id: GO:0048265
name: response to pain
namespace: biological_process
alt_id: GO:0048267
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jic, http://www.wikipedia.org/Pain, PMID:10203867, PMID:12723742, PMID:12843304]
synonym: "physiological response to pain" EXACT []
is_a: GO:0033555 ! multicellular organismal response to stress

[Term]
id: GO:0048266
name: behavioral response to pain
namespace: biological_process
def: "A change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jic, http://cancerweb.ncl.ac.uk]
synonym: "behavioural response to pain" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0048265 ! response to pain

[Term]
id: GO:0048268
name: clathrin coat assembly
namespace: biological_process
def: "The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage." [GOC:jic, PMID:11460887, PMID:11977118, PMID:9531549]
synonym: "clathrin cage assembly" EXACT []
is_a: GO:0006901 ! vesicle coating
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0048269
name: methionine adenosyltransferase complex
namespace: cellular_component
def: "A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules." [EC:2.5.1.6, GOC:jic, PMID:10644686]
synonym: "MAT complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0048270
name: methionine adenosyltransferase regulator activity
namespace: molecular_function
def: "Modulates the activity of methionine adenosyltransferase." [EC:2.5.1.6, GOC:jic, PMID:10644686]
comment: See also the molecular function term 'methionine adenosyltransferase activity ; GO:0004478'.
synonym: "MAT regulator activity" EXACT []
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0048273
name: mitogen-activated protein kinase p38 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation." [http://cancerweb.ncl.ac.uk]
synonym: "MAPK p38 binding" EXACT []
is_a: GO:0051019 ! mitogen-activated protein kinase binding

[Term]
id: GO:0048275
name: N-terminal peptidyl-arginine acetylation
namespace: biological_process
def: "The acetylation of the N-terminal arginine of proteins; catalyzed by an uncharacterized arginyl-peptide alpha-N-acetyltransferase." [GOC:jsg, PMID:12883043, RESID:AA0354]
subset: gosubset_prok
xref: RESID:AA0354
is_a: GO:0006474 ! N-terminal protein amino acid acetylation
is_a: GO:0018195 ! peptidyl-arginine modification

[Term]
id: GO:0048277
name: nonexocytotic vesicle docking
namespace: biological_process
def: "OBSOLETE. The initial attachment of a transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, during a non-exocytotic process." [GOC:jic]
comment: This term was made obsolete because it violates the principle of positivity.
synonym: "non-exocytotic vesicle docking" EXACT []
is_obsolete: true
replaced_by: GO:0048278

[Term]
id: GO:0048278
name: vesicle docking
namespace: biological_process
def: "The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jic]
subset: gosubset_prok
synonym: "vesicle to membrane docking" EXACT []
is_a: GO:0022406 ! membrane docking
relationship: part_of GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0048279
name: vesicle fusion with endoplasmic reticulum
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the endoplasmic reticulum." [GOC:jic]
synonym: "vesicle fusion with ER" EXACT []
is_a: GO:0006906 ! vesicle fusion

[Term]
id: GO:0048280
name: vesicle fusion with Golgi apparatus
namespace: biological_process
def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jic]
is_a: GO:0006906 ! vesicle fusion

[Term]
id: GO:0048281
name: inflorescence morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of inflorescences are generated and organized. Morphogenesis pertains to the creation of form. An inflorescence is the part of a seed plant body that is usually above ground and that can bear flowers." [GOC:jic]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0010229 ! inflorescence development

[Term]
id: GO:0048282
name: determinate inflorescence morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of determinate inflorescences are generated and organized. Morphogenesis pertains to the creation of form. A determinate inflorescence is one that can only produce a predetermined number of floral meristems." [GOC:jic, PMID:9553044]
is_a: GO:0048281 ! inflorescence morphogenesis

[Term]
id: GO:0048283
name: indeterminate inflorescence morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of determinate inflorescences are generated and organized. Morphogenesis pertains to the creation of form. A determinate inflorescence is one that can produce an undefined number of floral meristems." [GOC:jic]
is_a: GO:0048281 ! inflorescence morphogenesis

[Term]
id: GO:0048284
name: organelle fusion
namespace: biological_process
def: "The creation of a single organelle from two or more organelles." [GOC:jic]
subset: goslim_pir
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0048285
name: organelle fission
namespace: biological_process
def: "The creation of two or more organelles by division of one organelle." [GOC:jic]
subset: goslim_pir
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0048286
name: lung alveolus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways." [GOC:mtg_lung, PMID:9751757]
synonym: "alveolarization" EXACT [PMID:17911382]
synonym: "alveologenesis" EXACT [GOC:17911382]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0048288
name: nuclear membrane fusion during karyogamy
namespace: biological_process
def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei." [GOC:jic]
is_a: GO:0000740 ! nuclear membrane fusion
relationship: part_of GO:0000741 ! karyogamy

[Term]
id: GO:0048289
name: isotype switching to IgE isotypes
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149 "Fundamental Immunology", PMID:12370374, PMID:2113175, PMID:9186655]
synonym: "class switch recombination to IgE isotypes" EXACT []
synonym: "class switching to IgE isotypes" EXACT []
synonym: "isotype switch recombination to IgE isotypes" EXACT []
is_a: GO:0045190 ! isotype switching

[Term]
id: GO:0048290
name: isotype switching to IgA isotypes
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149 "Fundamental Immunology", PMID:12370374, PMID:2113175, PMID:9186655]
synonym: "class switching to IgA isotypes" EXACT []
synonym: "isotype switch recombination to IgA isotypes" EXACT []
is_a: GO:0045190 ! isotype switching

[Term]
id: GO:0048291
name: isotype switching to IgG isotypes
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149 "Fundamental Immunology", PMID:12370374, PMID:2113175, PMID:9186655]
synonym: "class switching to IgG isotypes" EXACT []
synonym: "isotype switch recombination to IgG isotypes" EXACT []
is_a: GO:0045190 ! isotype switching

[Term]
id: GO:0048292
name: isotype switching to IgD isotypes
namespace: biological_process
def: "The switching of activated B cells from IgM biosynthesis to IgD biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgD constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149 "Fundamental Immunology", PMID:12370374, PMID:2113175, PMID:9186655]
comment: Note that this term is to be used only for gene products involved in the expression of IgD through recombinational switching into the vestigial switch region at the 5' end of the IgD gene segment, rather than gene products involved in the expression of IgD through alternative splicing mechanisms.
synonym: "class switching to IgD isotypes" EXACT []
synonym: "isotype switch recombination to IgD isotypes" EXACT []
is_a: GO:0045190 ! isotype switching

[Term]
id: GO:0048293
name: regulation of isotype switching to IgE isotypes
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jic]
synonym: "regulation of class switch recombination to IgE isotypes" EXACT []
synonym: "regulation of class switching to IgE isotypes" EXACT []
synonym: "regulation of isotype switch recombination to IgE isotypes" EXACT []
is_a: GO:0045191 ! regulation of isotype switching
relationship: regulates GO:0048289 ! isotype switching to IgE isotypes

[Term]
id: GO:0048294
name: negative regulation of isotype switching to IgE isotypes
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jic]
synonym: "down regulation of isotype switching to IgE isotypes" EXACT []
synonym: "down-regulation of isotype switching to IgE isotypes" EXACT []
synonym: "downregulation of isotype switching to IgE isotypes" EXACT []
synonym: "inhibition of isotype switching to IgE isotypes" NARROW []
synonym: "negative regulation of class switch recombination to IgE isotypes" EXACT []
synonym: "negative regulation of class switching to IgE isotypes" EXACT []
synonym: "negative regulation of isotype switch recombination to IgE isotypes" EXACT []
is_a: GO:0045829 ! negative regulation of isotype switching
is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes
relationship: negatively_regulates GO:0048289 ! isotype switching to IgE isotypes

[Term]
id: GO:0048295
name: positive regulation of isotype switching to IgE isotypes
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jic]
synonym: "activation of isotype switching to IgE isotypes" NARROW []
synonym: "positive regulation of class switch recombination to IgE isotypes" EXACT []
synonym: "positive regulation of class switching to IgE isotypes" EXACT []
synonym: "positive regulation of isotype switch recombination to IgE isotypes" EXACT []
synonym: "stimulation of isotype switching to IgE isotypes" NARROW []
synonym: "up regulation of isotype switching to IgE isotypes" EXACT []
synonym: "up-regulation of isotype switching to IgE isotypes" EXACT []
synonym: "upregulation of isotype switching to IgE isotypes" EXACT []
is_a: GO:0045830 ! positive regulation of isotype switching
is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes
relationship: positively_regulates GO:0048289 ! isotype switching to IgE isotypes

[Term]
id: GO:0048296
name: regulation of isotype switching to IgA isotypes
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jic]
synonym: "regulation of class switch recombination to IgA isotypes" EXACT []
synonym: "regulation of class switching to IgA isotypes" EXACT []
synonym: "regulation of isotype switch recombination to IgA isotypes" EXACT []
is_a: GO:0045191 ! regulation of isotype switching
relationship: regulates GO:0048290 ! isotype switching to IgA isotypes

[Term]
id: GO:0048297
name: negative regulation of isotype switching to IgA isotypes
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jic]
synonym: "down regulation of isotype switching to IgA isotypes" EXACT []
synonym: "down-regulation of isotype switching to IgA isotypes" EXACT []
synonym: "downregulation of isotype switching to IgA isotypes" EXACT []
synonym: "inhibition of isotype switching to IgA isotypes" NARROW []
synonym: "negative regulation of class switch recombination to IgA isotypes" EXACT []
synonym: "negative regulation of class switching to IgA isotypes" EXACT []
synonym: "negative regulation of isotype switch recombination to IgA isotypes" EXACT []
is_a: GO:0045829 ! negative regulation of isotype switching
is_a: GO:0048296 ! regulation of isotype switching to IgA isotypes
relationship: negatively_regulates GO:0048290 ! isotype switching to IgA isotypes

[Term]
id: GO:0048298
name: positive regulation of isotype switching to IgA isotypes
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jic]
synonym: "activation of isotype switching to IgA isotypes" NARROW []
synonym: "positive regulation of class switch recombination to IgA isotypes" EXACT []
synonym: "positive regulation of class switching to IgA isotypes" EXACT []
synonym: "positive regulation of isotype switch recombination to IgA isotypes" EXACT []
synonym: "stimulation of isotype switching to IgA isotypes" NARROW []
synonym: "up regulation of isotype switching to IgA isotypes" EXACT []
synonym: "up-regulation of isotype switching to IgA isotypes" EXACT []
synonym: "upregulation of isotype switching to IgA isotypes" EXACT []
is_a: GO:0045830 ! positive regulation of isotype switching
is_a: GO:0048296 ! regulation of isotype switching to IgA isotypes
relationship: positively_regulates GO:0048290 ! isotype switching to IgA isotypes

[Term]
id: GO:0048299
name: regulation of isotype switching to IgD isotypes
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jic]
synonym: "regulation of class switch recombination to IgD isotypes" EXACT []
synonym: "regulation of class switching to IgD isotypes" EXACT []
synonym: "regulation of isotype switch recombination to IgD isotypes" EXACT []
is_a: GO:0045191 ! regulation of isotype switching
relationship: regulates GO:0048292 ! isotype switching to IgD isotypes

[Term]
id: GO:0048300
name: negative regulation of isotype switching to IgD isotypes
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jic]
synonym: "down regulation of isotype switching to IgD isotypes" EXACT []
synonym: "down-regulation of isotype switching to IgD isotypes" EXACT []
synonym: "downregulation of isotype switching to IgD isotypes" EXACT []
synonym: "inhibition of isotype switching to IgD isotypes" NARROW []
synonym: "negative regulation of class switch recombination to IgD isotypes" EXACT []
synonym: "negative regulation of class switching to IgD isotypes" EXACT []
synonym: "negative regulation of isotype switch recombination to IgD isotypes" EXACT []
is_a: GO:0045829 ! negative regulation of isotype switching
is_a: GO:0048299 ! regulation of isotype switching to IgD isotypes
relationship: negatively_regulates GO:0048292 ! isotype switching to IgD isotypes

[Term]
id: GO:0048301
name: positive regulation of isotype switching to IgD isotypes
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jic]
synonym: "activation of isotype switching to IgD isotypes" NARROW []
synonym: "positive regulation of class switch recombination to IgD isotypes" EXACT []
synonym: "positive regulation of class switching to IgD isotypes" EXACT []
synonym: "positive regulation of isotype switch recombination to IgD isotypes" EXACT []
synonym: "stimulation of isotype switching to IgD isotypes" NARROW []
synonym: "up regulation of isotype switching to IgD isotypes" EXACT []
synonym: "up-regulation of isotype switching to IgD isotypes" EXACT []
synonym: "upregulation of isotype switching to IgD isotypes" EXACT []
is_a: GO:0045830 ! positive regulation of isotype switching
is_a: GO:0048299 ! regulation of isotype switching to IgD isotypes
relationship: positively_regulates GO:0048292 ! isotype switching to IgD isotypes

[Term]
id: GO:0048302
name: regulation of isotype switching to IgG isotypes
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jic]
synonym: "regulation of class switch recombination to IgG isotypes" EXACT []
synonym: "regulation of class switching to IgG isotypes" EXACT []
synonym: "regulation of isotype switch recombination to IgG isotypes" EXACT []
is_a: GO:0045191 ! regulation of isotype switching
relationship: regulates GO:0048291 ! isotype switching to IgG isotypes

[Term]
id: GO:0048303
name: negative regulation of isotype switching to IgG isotypes
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jic]
synonym: "down regulation of isotype switching to IgG isotypes" EXACT []
synonym: "down-regulation of isotype switching to IgG isotypes" EXACT []
synonym: "downregulation of isotype switching to IgG isotypes" EXACT []
synonym: "inhibition of isotype switching to IgG isotypes" NARROW []
synonym: "negative regulation of class switch recombination to IgG isotypes" EXACT []
synonym: "negative regulation of class switching to IgG isotypes" EXACT []
synonym: "negative regulation of isotype switch recombination to IgG isotypes" EXACT []
is_a: GO:0045829 ! negative regulation of isotype switching
is_a: GO:0048302 ! regulation of isotype switching to IgG isotypes
relationship: negatively_regulates GO:0048291 ! isotype switching to IgG isotypes

[Term]
id: GO:0048304
name: positive regulation of isotype switching to IgG isotypes
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jic]
synonym: "activation of isotype switching to IgG isotypes" NARROW []
synonym: "positive regulation of class switch recombination to IgG isotypes" EXACT []
synonym: "positive regulation of class switching to IgG isotypes" EXACT []
synonym: "positive regulation of isotype switch recombination to IgG isotypes" EXACT []
synonym: "stimulation of isotype switching to IgG isotypes" NARROW []
synonym: "up regulation of isotype switching to IgG isotypes" EXACT []
synonym: "up-regulation of isotype switching to IgG isotypes" EXACT []
synonym: "upregulation of isotype switching to IgG isotypes" EXACT []
is_a: GO:0045830 ! positive regulation of isotype switching
is_a: GO:0048302 ! regulation of isotype switching to IgG isotypes
relationship: positively_regulates GO:0048291 ! isotype switching to IgG isotypes

[Term]
id: GO:0048305
name: immunoglobulin secretion
namespace: biological_process
def: "The regulated release of immunoglobulins from a B cell or plasma cell, whose mechanism includes the use of alternate polyadenylylation signals to favor the biosynthesis of secreted forms of immunoglobulin over membrane-bound immunoglobulin." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:9185563]
synonym: "antibody secretion" EXACT []
is_a: GO:0009306 ! protein secretion
relationship: part_of GO:0002377 ! immunoglobulin production

[Term]
id: GO:0048306
name: calcium-dependent protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium." [GOC:jic, PMID:10485905]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0048307
name: ferredoxin-nitrite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = NO2(-) (nitrite) + 6 reduced ferredoxin + 7 H+." [EC:1.7.7.1, GOC:jic]
subset: gosubset_prok
synonym: "ammonia:ferredoxin oxidoreductase activity" EXACT [EC:1.7.7.1]
xref: EC:1.7.7.1
xref: MetaCyc:FERREDOXIN--NITRITE-REDUCTASE-RXN
is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor

[Term]
id: GO:0048308
name: organelle inheritance
namespace: biological_process
def: "The partitioning of organelles between daughter cells at cell division." [GOC:jic]
subset: goslim_pir
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0048309
name: endoplasmic reticulum inheritance
namespace: biological_process
def: "The partitioning of endoplasmic reticulum between daughter cells at cell division." [GOC:jic]
synonym: "ER inheritance" EXACT []
is_a: GO:0007029 ! endoplasmic reticulum organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0048310
name: nucleus inheritance
namespace: biological_process
def: "The partitioning of nuclei between daughter cells at cell division." [GOC:jic]
synonym: "cell nucleus inheritance" EXACT []
is_a: GO:0006997 ! nucleus organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0048311
name: mitochondrion distribution
namespace: biological_process
def: "Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jic]
synonym: "distribution of mitochondria" EXACT []
synonym: "mitochondrial distribution" EXACT []
synonym: "positioning of mitochondria" RELATED []
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0051646 ! mitochondrion localization

[Term]
id: GO:0048312
name: intracellular distribution of mitochondria
namespace: biological_process
def: "Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jic]
synonym: "mitochondria positioning within cell" EXACT []
synonym: "mitochondrion positioning within cell" EXACT []
is_a: GO:0048311 ! mitochondrion distribution

[Term]
id: GO:0048313
name: Golgi inheritance
namespace: biological_process
def: "The partitioning of Golgi apparatus between daughter cells at cell division." [GOC:jic, PMID:12851069]
synonym: "Golgi division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "Golgi partitioning" EXACT []
is_a: GO:0007030 ! Golgi organization
is_a: GO:0048308 ! organelle inheritance

[Term]
id: GO:0048314
name: embryo sac morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the embryo sac are generated and organized. Morphogenesis pertains to the creation of form. The embryo sac develops from the megaspore in heterosporous plants." [GOC:jic, GOC:mtg_plant, http://www.bio.uu.nl]
synonym: "female gametophyte morphogenesis" EXACT []
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0048315
name: conidium formation
namespace: biological_process
def: "Formation of asexual, nonmotile spores in fungi, by conversion of hyphal elements or arising from specialized sporogenous cells." [ISBN:0963117211, PMID:2524423, PMID:9529886]
synonym: "conidia biosynthesis" EXACT []
synonym: "conidia formation" EXACT []
is_a: GO:0030436 ! asexual sporulation
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0048316
name: seed development
namespace: biological_process
def: "The process whose specific outcome is the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0010154 ! fruit development

[Term]
id: GO:0048317
name: seed morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the seed are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0048318
name: axial mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [GOC:dgh]
is_a: GO:0007498 ! mesoderm development

[Term]
id: GO:0048319
name: axial mesoderm morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the axial mesoderm are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0048332 ! mesoderm morphogenesis
relationship: part_of GO:0048318 ! axial mesoderm development

[Term]
id: GO:0048320
name: axial mesoderm formation
namespace: biological_process
def: "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh]
is_a: GO:0001707 ! mesoderm formation
relationship: part_of GO:0048319 ! axial mesoderm morphogenesis

[Term]
id: GO:0048321
name: axial mesodermal cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of an axial mesoderm cell." [GOC:dgh]
synonym: "axial mesoderm cell differentiation" EXACT []
is_a: GO:0048333 ! mesodermal cell differentiation
relationship: part_of GO:0048320 ! axial mesoderm formation

[Term]
id: GO:0048322
name: axial mesodermal cell fate commitment
namespace: biological_process
def: "The process by which a cell becomes committed to become an axial mesoderm cell." [GOC:dgh]
synonym: "axial mesoderm cell fate commitment" EXACT []
is_a: GO:0001710 ! mesodermal cell fate commitment
relationship: part_of GO:0048321 ! axial mesodermal cell differentiation

[Term]
id: GO:0048323
name: axial mesodermal cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into an axial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh]
synonym: "axial mesoderm cell fate determination" EXACT []
is_a: GO:0007500 ! mesodermal cell fate determination
relationship: part_of GO:0048322 ! axial mesodermal cell fate commitment

[Term]
id: GO:0048324
name: regulation of axial mesodermal cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh]
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
relationship: regulates GO:0048323 ! axial mesodermal cell fate determination

[Term]
id: GO:0048325
name: negative regulation of axial mesodermal cell fate determination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh]
synonym: "down regulation of axial mesodermal cell fate determination" EXACT []
synonym: "down-regulation of axial mesodermal cell fate determination" EXACT []
synonym: "downregulation of axial mesodermal cell fate determination" EXACT []
synonym: "inhibition of axial mesodermal cell fate determination" NARROW []
is_a: GO:0048324 ! regulation of axial mesodermal cell fate determination
is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination
relationship: negatively_regulates GO:0048323 ! axial mesodermal cell fate determination

[Term]
id: GO:0048326
name: positive regulation of axial mesodermal cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh]
synonym: "activation of axial mesodermal cell fate determination" NARROW []
synonym: "stimulation of axial mesodermal cell fate determination" NARROW []
synonym: "up regulation of axial mesodermal cell fate determination" EXACT []
synonym: "up-regulation of axial mesodermal cell fate determination" EXACT []
synonym: "upregulation of axial mesodermal cell fate determination" EXACT []
is_a: GO:0048324 ! regulation of axial mesodermal cell fate determination
is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination
relationship: positively_regulates GO:0048323 ! axial mesodermal cell fate determination

[Term]
id: GO:0048327
name: axial mesodermal cell fate specification
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into an axial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh]
synonym: "axial mesoderm cell fate specification" EXACT []
is_a: GO:0007501 ! mesodermal cell fate specification
relationship: part_of GO:0048322 ! axial mesodermal cell fate commitment

[Term]
id: GO:0048328
name: regulation of axial mesodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh]
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
relationship: regulates GO:0048327 ! axial mesodermal cell fate specification

[Term]
id: GO:0048329
name: negative regulation of axial mesodermal cell fate specification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh]
synonym: "down regulation of axial mesodermal cell fate specification" EXACT []
synonym: "down-regulation of axial mesodermal cell fate specification" EXACT []
synonym: "downregulation of axial mesodermal cell fate specification" EXACT []
synonym: "inhibition of axial mesodermal cell fate specification" NARROW []
is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification
is_a: GO:0048328 ! regulation of axial mesodermal cell fate specification
relationship: negatively_regulates GO:0048327 ! axial mesodermal cell fate specification

[Term]
id: GO:0048330
name: positive regulation of axial mesodermal cell fate specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh]
synonym: "activation of axial mesodermal cell fate specification" NARROW []
synonym: "stimulation of axial mesodermal cell fate specification" NARROW []
synonym: "up regulation of axial mesodermal cell fate specification" EXACT []
synonym: "up-regulation of axial mesodermal cell fate specification" EXACT []
synonym: "upregulation of axial mesodermal cell fate specification" EXACT []
is_a: GO:0048328 ! regulation of axial mesodermal cell fate specification
is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification
relationship: positively_regulates GO:0048327 ! axial mesodermal cell fate specification

[Term]
id: GO:0048331
name: axial mesoderm structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the axial mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh]
synonym: "axial mesoderm structural organisation" EXACT [GOC:curators]
is_a: GO:0048338 ! mesoderm structural organization
relationship: part_of GO:0048319 ! axial mesoderm morphogenesis

[Term]
id: GO:0048332
name: mesoderm morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the mesoderm are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0007498 ! mesoderm development

[Term]
id: GO:0048333
name: mesodermal cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a mesoderm cell." [GOC:dgh]
synonym: "mesoderm cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001707 ! mesoderm formation

[Term]
id: GO:0048334
name: regulation of mesodermal cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0010470 ! regulation of gastrulation
relationship: regulates GO:0007500 ! mesodermal cell fate determination

[Term]
id: GO:0048335
name: negative regulation of mesodermal cell fate determination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh]
synonym: "down regulation of mesodermal cell fate determination" EXACT []
synonym: "down-regulation of mesodermal cell fate determination" EXACT []
synonym: "downregulation of mesodermal cell fate determination" EXACT []
synonym: "inhibition of mesodermal cell fate determination" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
relationship: negatively_regulates GO:0007500 ! mesodermal cell fate determination

[Term]
id: GO:0048336
name: positive regulation of mesodermal cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh]
synonym: "activation of mesodermal cell fate determination" NARROW []
synonym: "stimulation of mesodermal cell fate determination" NARROW []
synonym: "up regulation of mesodermal cell fate determination" EXACT []
synonym: "up-regulation of mesodermal cell fate determination" EXACT []
synonym: "upregulation of mesodermal cell fate determination" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
relationship: positively_regulates GO:0007500 ! mesodermal cell fate determination

[Term]
id: GO:0048337
name: positive regulation of mesodermal cell fate specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification." [GOC:dgh]
synonym: "activation of mesodermal cell fate specification" NARROW []
synonym: "stimulation of mesodermal cell fate specification" NARROW []
synonym: "up regulation of mesodermal cell fate specification" EXACT []
synonym: "up-regulation of mesodermal cell fate specification" EXACT []
synonym: "upregulation of mesodermal cell fate specification" EXACT []
is_a: GO:0042660 ! positive regulation of cell fate specification
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
relationship: positively_regulates GO:0007501 ! mesodermal cell fate specification

[Term]
id: GO:0048338
name: mesoderm structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh]
synonym: "mesoderm structural organisation" EXACT [GOC:curators]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0048332 ! mesoderm morphogenesis

[Term]
id: GO:0048339
name: paraxial mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube." [GOC:dgh]
is_a: GO:0007498 ! mesoderm development

[Term]
id: GO:0048340
name: paraxial mesoderm morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the paraxial mesoderm are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0048332 ! mesoderm morphogenesis
relationship: part_of GO:0048339 ! paraxial mesoderm development

[Term]
id: GO:0048341
name: paraxial mesoderm formation
namespace: biological_process
def: "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh]
is_a: GO:0001707 ! mesoderm formation
relationship: part_of GO:0048340 ! paraxial mesoderm morphogenesis

[Term]
id: GO:0048342
name: paraxial mesodermal cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a paraxial mesoderm cell." [GOC:dgh]
is_a: GO:0048333 ! mesodermal cell differentiation
relationship: part_of GO:0048341 ! paraxial mesoderm formation

[Term]
id: GO:0048343
name: paraxial mesodermal cell fate commitment
namespace: biological_process
def: "The process by which a cell becomes committed to become a paraxial mesoderm cell." [GOC:dgh]
is_a: GO:0001710 ! mesodermal cell fate commitment
relationship: part_of GO:0048342 ! paraxial mesodermal cell differentiation

[Term]
id: GO:0048344
name: paraxial mesodermal cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh]
is_a: GO:0007500 ! mesodermal cell fate determination
relationship: part_of GO:0048343 ! paraxial mesodermal cell fate commitment

[Term]
id: GO:0048345
name: regulation of paraxial mesodermal cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh]
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
relationship: regulates GO:0048344 ! paraxial mesodermal cell fate determination

[Term]
id: GO:0048346
name: positive regulation of paraxial mesodermal cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh]
synonym: "activation of paraxial mesodermal cell fate determination" NARROW []
synonym: "stimulation of paraxial mesodermal cell fate determination" NARROW []
synonym: "up regulation of paraxial mesodermal cell fate determination" EXACT []
synonym: "up-regulation of paraxial mesodermal cell fate determination" EXACT []
synonym: "upregulation of paraxial mesodermal cell fate determination" EXACT []
is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination
is_a: GO:0048345 ! regulation of paraxial mesodermal cell fate determination
relationship: positively_regulates GO:0048344 ! paraxial mesodermal cell fate determination

[Term]
id: GO:0048347
name: negative regulation of paraxial mesodermal cell fate determination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh]
synonym: "down regulation of paraxial mesodermal cell fate determination" EXACT []
synonym: "down-regulation of paraxial mesodermal cell fate determination" EXACT []
synonym: "downregulation of paraxial mesodermal cell fate determination" EXACT []
synonym: "inhibition of paraxial mesodermal cell fate determination" NARROW []
is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination
is_a: GO:0048345 ! regulation of paraxial mesodermal cell fate determination
relationship: negatively_regulates GO:0048344 ! paraxial mesodermal cell fate determination

[Term]
id: GO:0048348
name: paraxial mesodermal cell fate specification
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh]
is_a: GO:0007501 ! mesodermal cell fate specification
relationship: part_of GO:0048343 ! paraxial mesodermal cell fate commitment

[Term]
id: GO:0048349
name: regulation of paraxial mesodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh]
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
relationship: regulates GO:0048348 ! paraxial mesodermal cell fate specification

[Term]
id: GO:0048350
name: positive regulation of paraxial mesodermal cell fate specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh]
synonym: "activation of paraxial mesodermal cell fate specification" NARROW []
synonym: "stimulation of paraxial mesodermal cell fate specification" NARROW []
synonym: "up regulation of paraxial mesodermal cell fate specification" EXACT []
synonym: "up-regulation of paraxial mesodermal cell fate specification" EXACT []
synonym: "upregulation of paraxial mesodermal cell fate specification" EXACT []
is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification
is_a: GO:0048349 ! regulation of paraxial mesodermal cell fate specification
relationship: positively_regulates GO:0048348 ! paraxial mesodermal cell fate specification

[Term]
id: GO:0048351
name: negative regulation of paraxial mesodermal cell fate specification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh]
synonym: "down regulation of paraxial mesodermal cell fate specification" EXACT []
synonym: "down-regulation of paraxial mesodermal cell fate specification" EXACT []
synonym: "downregulation of paraxial mesodermal cell fate specification" EXACT []
synonym: "inhibition of paraxial mesodermal cell fate specification" NARROW []
is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification
is_a: GO:0048349 ! regulation of paraxial mesodermal cell fate specification
relationship: negatively_regulates GO:0048348 ! paraxial mesodermal cell fate specification

[Term]
id: GO:0048352
name: paraxial mesoderm structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the paraxial mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh]
synonym: "paraxial mesoderm structural organisation" EXACT [GOC:curators]
is_a: GO:0048338 ! mesoderm structural organization
relationship: part_of GO:0048340 ! paraxial mesoderm morphogenesis

[Term]
id: GO:0048353
name: primary endosperm nucleus
namespace: cellular_component
def: "Nucleus resulting from the fusion of the male gamete and two polar nuclei in the central cell of the embryo sac." [ISBN:0471245208]
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0048354
name: mucilage biosynthetic process during seed coat development
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mucilage that occur during seed coat development; mucilage is normally synthesized during seed coat development." [GOC:jic]
synonym: "mucilage anabolism during seed coat development" EXACT []
synonym: "mucilage formation during seed coat development" EXACT []
synonym: "mucilage synthesis during seed coat development" EXACT []
is_a: GO:0010192 ! mucilage biosynthetic process
is_a: GO:0048359 ! mucilage metabolic process during seed coat development

[Term]
id: GO:0048355
name: root cap mucilage biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the root cap; mucilage is normally synthesized during root growth." [GOC:jic]
synonym: "root cap mucilage anabolism" EXACT []
synonym: "root cap mucilage biosynthesis" EXACT []
synonym: "root cap mucilage formation" EXACT []
synonym: "root cap mucilage synthesis" EXACT []
is_a: GO:0010192 ! mucilage biosynthetic process
relationship: part_of GO:0048360 ! root cap mucilage metabolic process

[Term]
id: GO:0048356
name: root epithelial mucilage biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth." [GOC:jic]
synonym: "root epithelial mucilage anabolism" EXACT []
synonym: "root epithelial mucilage biosynthesis" EXACT []
synonym: "root epithelial mucilage formation" EXACT []
synonym: "root epithelial mucilage synthesis" EXACT []
is_a: GO:0010192 ! mucilage biosynthetic process
relationship: part_of GO:0048361 ! root epithelial mucilage metabolic process

[Term]
id: GO:0048357
name: pedicel mucilage biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the flower stem." [GOC:jic]
synonym: "pedicel mucilage anabolism" EXACT []
synonym: "pedicel mucilage biosynthesis" EXACT []
synonym: "pedicel mucilage formation" EXACT []
synonym: "pedicel mucilage synthesis" EXACT []
is_a: GO:0010192 ! mucilage biosynthetic process
relationship: part_of GO:0048362 ! pedicel mucilage metabolic process

[Term]
id: GO:0048358
name: mucilage pectin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the pectin component of mucilage." [GOC:jic]
synonym: "mucilage pectin anabolism" EXACT []
synonym: "mucilage pectin biosynthesis" EXACT []
synonym: "mucilage pectin formation" EXACT []
synonym: "mucilage pectin synthesis" EXACT []
is_a: GO:0045489 ! pectin biosynthetic process
is_a: GO:0048363 ! mucilage pectin metabolic process
relationship: part_of GO:0010192 ! mucilage biosynthetic process

[Term]
id: GO:0048359
name: mucilage metabolic process during seed coat development
namespace: biological_process
def: "The chemical reactions and pathways involving mucilage that occur during seed coat development; mucilage is normally synthesized during seed coat development." [GOC:jic]
synonym: "mucilage metabolism during seed coat development" EXACT []
is_a: GO:0010191 ! mucilage metabolic process
relationship: part_of GO:0010214 ! seed coat development

[Term]
id: GO:0048360
name: root cap mucilage metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mucilage that occur in the root cap; mucilage is normally synthesized during root growth." [GOC:jic]
synonym: "root cap mucilage metabolism" EXACT []
is_a: GO:0010191 ! mucilage metabolic process

[Term]
id: GO:0048361
name: root epithelial mucilage metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth." [GOC:jic]
synonym: "root epithelial mucilage metabolism" EXACT []
is_a: GO:0010191 ! mucilage metabolic process

[Term]
id: GO:0048362
name: pedicel mucilage metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mucilage that occur in the flower stem." [GOC:jic]
synonym: "pedicel mucilage metabolism" EXACT []
is_a: GO:0010191 ! mucilage metabolic process

[Term]
id: GO:0048363
name: mucilage pectin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the pectin component of mucilage." [GOC:jic]
synonym: "mucilage pectin metabolism" EXACT []
is_a: GO:0045488 ! pectin metabolic process
relationship: part_of GO:0010191 ! mucilage metabolic process

[Term]
id: GO:0048364
name: root development
namespace: biological_process
def: "The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0048513 ! organ development
relationship: part_of GO:0022622 ! root system development

[Term]
id: GO:0048365
name: Rac GTPase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases." [GOC:ebc, PMID:11702775]
is_a: GO:0017048 ! Rho GTPase binding

[Term]
id: GO:0048366
name: leaf development
namespace: biological_process
def: "The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048827 ! phyllome development

[Term]
id: GO:0048367
name: shoot development
namespace: biological_process
def: "The process whose specific outcome is the progression of the shoot over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048513 ! organ development
relationship: part_of GO:0022621 ! shoot system development

[Term]
id: GO:0048368
name: lateral mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure." [GOC:go_curators]
synonym: "lateral plate mesoderm development" EXACT []
is_a: GO:0007498 ! mesoderm development

[Term]
id: GO:0048369
name: lateral mesoderm morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the lateral mesoderm are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
synonym: "lateral plate mesoderm morphogenesis" EXACT []
is_a: GO:0048332 ! mesoderm morphogenesis
relationship: part_of GO:0048368 ! lateral mesoderm development

[Term]
id: GO:0048370
name: lateral mesoderm formation
namespace: biological_process
def: "The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:jic]
synonym: "lateral plate mesoderm biosynthesis" EXACT []
synonym: "lateral plate mesoderm formation" EXACT []
is_a: GO:0001707 ! mesoderm formation
relationship: part_of GO:0048369 ! lateral mesoderm morphogenesis

[Term]
id: GO:0048371
name: lateral mesodermal cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a lateral mesoderm cell." [GOC:jic]
synonym: "lateral mesoderm cell differentiation" EXACT []
synonym: "lateral plate mesoderm cell differentiation" EXACT []
synonym: "lateral plate mesodermal cell differentiation" EXACT []
is_a: GO:0048333 ! mesodermal cell differentiation
relationship: part_of GO:0048370 ! lateral mesoderm formation

[Term]
id: GO:0048372
name: lateral mesodermal cell fate commitment
namespace: biological_process
def: "The process by which a cell becomes committed to become a lateral mesoderm cell." [GOC:jic]
synonym: "lateral mesoderm cell fate commitment" EXACT []
synonym: "lateral plate mesoderm cell fate commitment" EXACT []
synonym: "lateral plate mesodermal cell fate commitment" EXACT []
is_a: GO:0001710 ! mesodermal cell fate commitment
relationship: part_of GO:0048371 ! lateral mesodermal cell differentiation

[Term]
id: GO:0048373
name: lateral mesodermal cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:jic]
synonym: "lateral mesoderm cell fate determination" EXACT []
synonym: "lateral plate mesoderm cell fate determination" EXACT []
synonym: "lateral plate mesodermal cell fate determination" EXACT []
is_a: GO:0007500 ! mesodermal cell fate determination
relationship: part_of GO:0048372 ! lateral mesodermal cell fate commitment

[Term]
id: GO:0048374
name: regulation of lateral mesodermal cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jic]
synonym: "regulation of lateral mesoderm cell fate determination" EXACT []
synonym: "regulation of lateral plate mesoderm cell fate determination" EXACT []
synonym: "regulation of lateral plate mesodermal cell fate determination" EXACT []
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
relationship: regulates GO:0048373 ! lateral mesodermal cell fate determination

[Term]
id: GO:0048375
name: negative regulation of lateral mesodermal cell fate determination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jic]
synonym: "down regulation of lateral mesodermal cell fate determination" EXACT []
synonym: "down-regulation of lateral mesodermal cell fate determination" EXACT []
synonym: "downregulation of lateral mesodermal cell fate determination" EXACT []
synonym: "inhibition of lateral mesodermal cell fate determination" NARROW []
synonym: "negative regulation of lateral plate mesodermal cell fate determination" EXACT []
is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination
is_a: GO:0048374 ! regulation of lateral mesodermal cell fate determination
relationship: negatively_regulates GO:0048373 ! lateral mesodermal cell fate determination

[Term]
id: GO:0048376
name: positive regulation of lateral mesodermal cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jic]
synonym: "activation of lateral mesodermal cell fate determination" NARROW []
synonym: "positive regulation of lateral plate mesodermal cell fate determination" EXACT []
synonym: "stimulation of lateral mesodermal cell fate determination" NARROW []
synonym: "up regulation of lateral mesodermal cell fate determination" EXACT []
synonym: "up-regulation of lateral mesodermal cell fate determination" EXACT []
synonym: "upregulation of lateral mesodermal cell fate determination" EXACT []
is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination
is_a: GO:0048374 ! regulation of lateral mesodermal cell fate determination
relationship: positively_regulates GO:0048373 ! lateral mesodermal cell fate determination

[Term]
id: GO:0048377
name: lateral mesodermal cell fate specification
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:jic]
synonym: "lateral mesoderm cell fate specification" EXACT []
synonym: "lateral plate mesoderm cell fate specification" EXACT []
synonym: "lateral plate mesodermal cell fate specification" EXACT []
is_a: GO:0007501 ! mesodermal cell fate specification
relationship: part_of GO:0048372 ! lateral mesodermal cell fate commitment

[Term]
id: GO:0048378
name: regulation of lateral mesodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jic]
synonym: "regulation of lateral plate mesodermal cell fate specification" EXACT []
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
relationship: regulates GO:0048377 ! lateral mesodermal cell fate specification

[Term]
id: GO:0048379
name: positive regulation of lateral mesodermal cell fate specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jic]
synonym: "activation of lateral mesodermal cell fate specification" NARROW []
synonym: "positive regulation of lateral plate mesodermal cell fate specification" EXACT []
synonym: "stimulation of lateral mesodermal cell fate specification" NARROW []
synonym: "up regulation of lateral mesodermal cell fate specification" EXACT []
synonym: "up-regulation of lateral mesodermal cell fate specification" EXACT []
synonym: "upregulation of lateral mesodermal cell fate specification" EXACT []
is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification
is_a: GO:0048378 ! regulation of lateral mesodermal cell fate specification
relationship: positively_regulates GO:0048377 ! lateral mesodermal cell fate specification

[Term]
id: GO:0048380
name: negative regulation of lateral mesodermal cell fate specification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jic]
synonym: "down regulation of lateral mesodermal cell fate specification" EXACT []
synonym: "down-regulation of lateral mesodermal cell fate specification" EXACT []
synonym: "downregulation of lateral mesodermal cell fate specification" EXACT []
synonym: "inhibition of lateral mesodermal cell fate specification" NARROW []
synonym: "negative regulation of lateral plate mesodermal cell fate specification" EXACT []
is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification
is_a: GO:0048378 ! regulation of lateral mesodermal cell fate specification
relationship: negatively_regulates GO:0048377 ! lateral mesodermal cell fate specification

[Term]
id: GO:0048381
name: lateral mesoderm structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the lateral mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:jic]
synonym: "lateral mesoderm structural organisation" EXACT [GOC:curators]
synonym: "lateral plate mesoderm structural organization" EXACT []
is_a: GO:0048338 ! mesoderm structural organization
relationship: part_of GO:0048369 ! lateral mesoderm morphogenesis

[Term]
id: GO:0048382
name: mesendoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues." [GOC:jic]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007492 ! endoderm development
relationship: part_of GO:0007498 ! mesoderm development

[Term]
id: GO:0048383
name: mesectoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mesectoderm over time, from its formation to the mature structure. In animal embryos, mesectoderm development processes give rise to both mesoderm and ectoderm tissues." [GOC:jic]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007398 ! ectoderm development
relationship: part_of GO:0007498 ! mesoderm development

[Term]
id: GO:0048384
name: retinoic acid receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands." [GOC:dgh]
synonym: "RAR signaling pathway" EXACT []
synonym: "retinoic acid receptor signalling pathway" EXACT []
is_a: GO:0030522 ! intracellular receptor-mediated signaling pathway

[Term]
id: GO:0048385
name: regulation of retinoic acid receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh]
synonym: "regulation of RAR signaling pathway" EXACT []
synonym: "regulation of retinoic acid receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0048384 ! retinoic acid receptor signaling pathway

[Term]
id: GO:0048386
name: positive regulation of retinoic acid receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh]
synonym: "activation of retinoic acid receptor signaling pathway" NARROW []
synonym: "positive regulation of RAR signaling pathway" EXACT []
synonym: "positive regulation of retinoic acid receptor signalling pathway" EXACT []
synonym: "stimulation of retinoic acid receptor signaling pathway" NARROW []
synonym: "up regulation of retinoic acid receptor signaling pathway" EXACT []
synonym: "up-regulation of retinoic acid receptor signaling pathway" EXACT []
synonym: "upregulation of retinoic acid receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0048385 ! regulation of retinoic acid receptor signaling pathway
relationship: positively_regulates GO:0048384 ! retinoic acid receptor signaling pathway

[Term]
id: GO:0048387
name: negative regulation of retinoic acid receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh]
synonym: "down regulation of retinoic acid receptor signaling pathway" EXACT []
synonym: "down-regulation of retinoic acid receptor signaling pathway" EXACT []
synonym: "downregulation of retinoic acid receptor signaling pathway" EXACT []
synonym: "inhibition of retinoic acid receptor signaling pathway" NARROW []
synonym: "negative regulation of RAR signaling pathway" EXACT []
synonym: "negative regulation of RAR signalling pathway" EXACT []
synonym: "negative regulation of retinoic acid receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0048385 ! regulation of retinoic acid receptor signaling pathway
relationship: negatively_regulates GO:0048384 ! retinoic acid receptor signaling pathway

[Term]
id: GO:0048388
name: endosomal lumen acidification
namespace: biological_process
def: "Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jic]
is_a: GO:0051452 ! intracellular pH reduction
relationship: part_of GO:0007032 ! endosome organization

[Term]
id: GO:0048389
name: intermediate mesoderm development
namespace: biological_process
def: "The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [GOC:dgh]
is_a: GO:0007498 ! mesoderm development

[Term]
id: GO:0048390
name: intermediate mesoderm morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the intermediate mesoderm are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0048332 ! mesoderm morphogenesis
relationship: part_of GO:0048389 ! intermediate mesoderm development

[Term]
id: GO:0048391
name: intermediate mesoderm formation
namespace: biological_process
def: "The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh]
is_a: GO:0001707 ! mesoderm formation
relationship: part_of GO:0048390 ! intermediate mesoderm morphogenesis

[Term]
id: GO:0048392
name: intermediate mesodermal cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of an intermediate mesoderm cell." [GOC:dgh]
synonym: "intermediate mesoderm cell differentiation" EXACT []
is_a: GO:0048333 ! mesodermal cell differentiation
relationship: part_of GO:0048391 ! intermediate mesoderm formation

[Term]
id: GO:0048393
name: intermediate mesodermal cell fate commitment
namespace: biological_process
def: "The process by which the developmental fate of a cell becomes restricted such that it will develop into an intermediate mesoderm cell." [GOC:dgh]
synonym: "intermediate mesoderm cell fate commitment" EXACT []
is_a: GO:0001710 ! mesodermal cell fate commitment
relationship: part_of GO:0048392 ! intermediate mesodermal cell differentiation

[Term]
id: GO:0048394
name: intermediate mesodermal cell fate determination
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into a intermediate mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh]
synonym: "intermediate mesoderm cell fate determination" EXACT []
is_a: GO:0007500 ! mesodermal cell fate determination
relationship: part_of GO:0048393 ! intermediate mesodermal cell fate commitment

[Term]
id: GO:0048395
name: regulation of intermediate mesodermal cell fate determination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh]
is_a: GO:0048334 ! regulation of mesodermal cell fate determination
relationship: regulates GO:0048394 ! intermediate mesodermal cell fate determination

[Term]
id: GO:0048396
name: negative regulation of intermediate mesodermal cell fate determination
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh]
synonym: "down regulation of intermediate mesodermal cell fate determination" EXACT []
synonym: "down-regulation of intermediate mesodermal cell fate determination" EXACT []
synonym: "downregulation of intermediate mesodermal cell fate determination" EXACT []
synonym: "inhibition of intermediate mesodermal cell fate determination" NARROW []
is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination
is_a: GO:0048395 ! regulation of intermediate mesodermal cell fate determination
relationship: negatively_regulates GO:0048394 ! intermediate mesodermal cell fate determination

[Term]
id: GO:0048397
name: positive regulation of intermediate mesodermal cell fate determination
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh]
synonym: "activation of intermediate mesodermal cell fate determination" NARROW []
synonym: "stimulation of intermediate mesodermal cell fate determination" NARROW []
synonym: "up regulation of intermediate mesodermal cell fate determination" EXACT []
synonym: "up-regulation of intermediate mesodermal cell fate determination" EXACT []
synonym: "upregulation of intermediate mesodermal cell fate determination" EXACT []
is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination
is_a: GO:0048395 ! regulation of intermediate mesodermal cell fate determination
relationship: positively_regulates GO:0048394 ! intermediate mesodermal cell fate determination

[Term]
id: GO:0048398
name: intermediate mesodermal cell fate specification
namespace: biological_process
def: "Process by which a cell becomes capable of differentiating autonomously into an intermediate mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh]
synonym: "intermediate mesoderm cell fate specification" EXACT []
is_a: GO:0007501 ! mesodermal cell fate specification
relationship: part_of GO:0048393 ! intermediate mesodermal cell fate commitment

[Term]
id: GO:0048399
name: regulation of intermediate mesodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh]
is_a: GO:0042661 ! regulation of mesodermal cell fate specification
relationship: regulates GO:0048398 ! intermediate mesodermal cell fate specification

[Term]
id: GO:0048400
name: positive regulation of intermediate mesodermal cell fate specification
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh]
synonym: "activation of intermediate mesodermal cell fate specification" NARROW []
synonym: "stimulation of intermediate mesodermal cell fate specification" NARROW []
synonym: "up regulation of intermediate mesodermal cell fate specification" EXACT []
synonym: "up-regulation of intermediate mesodermal cell fate specification" EXACT []
synonym: "upregulation of intermediate mesodermal cell fate specification" EXACT []
is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification
is_a: GO:0048399 ! regulation of intermediate mesodermal cell fate specification
relationship: positively_regulates GO:0048398 ! intermediate mesodermal cell fate specification

[Term]
id: GO:0048401
name: negative regulation of intermediate mesodermal cell fate specification
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh]
synonym: "down regulation of intermediate mesodermal cell fate specification" EXACT []
synonym: "down-regulation of intermediate mesodermal cell fate specification" EXACT []
synonym: "downregulation of intermediate mesodermal cell fate specification" EXACT []
synonym: "inhibition of intermediate mesodermal cell fate specification" NARROW []
is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification
is_a: GO:0048399 ! regulation of intermediate mesodermal cell fate specification
relationship: negatively_regulates GO:0048398 ! intermediate mesodermal cell fate specification

[Term]
id: GO:0048402
name: intermediate mesoderm structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the intermediate mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh]
synonym: "intermediate mesoderm structural organisation" EXACT [GOC:curators]
is_a: GO:0048338 ! mesoderm structural organization
relationship: part_of GO:0048390 ! intermediate mesoderm morphogenesis

[Term]
id: GO:0048403
name: brain-derived neurotrophic factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with brain-derived neurotrophic factor." [GOC:dgh]
synonym: "BDNF binding" EXACT []
synonym: "neurotrophin TRKB receptor activity" RELATED []
is_a: GO:0043121 ! neurotrophin binding

[Term]
id: GO:0048404
name: neurotrophin-3 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with neurotrophin-3." [GOC:dgh]
synonym: "neurotrophin 3 binding" EXACT []
synonym: "neurotrophin TRKA receptor activity" RELATED []
synonym: "neurotrophin TRKB receptor activity" RELATED []
synonym: "neurotrophin TRKC receptor activity" RELATED []
synonym: "NT-3 binding" EXACT []
synonym: "NT3 binding" EXACT []
is_a: GO:0043121 ! neurotrophin binding

[Term]
id: GO:0048405
name: neurotrophin-4/5 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with neurotrophin-4/5." [GOC:dgh]
comment: Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858].
synonym: "neurotrophin 4/5 binding" EXACT []
synonym: "neurotrophin TRKB receptor activity" RELATED []
synonym: "NT 4/5 binding" EXACT []
synonym: "NT-4 binding" NARROW []
synonym: "NT-4/5 binding" EXACT []
synonym: "NT-5 binding" NARROW []
synonym: "NT4 binding" NARROW []
synonym: "NT5 binding" NARROW []
is_a: GO:0043121 ! neurotrophin binding

[Term]
id: GO:0048406
name: nerve growth factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with nerve growth factor." [GOC:dgh]
synonym: "neurotrophin TRKA receptor activity" RELATED []
synonym: "NGF binding" EXACT []
is_a: GO:0043121 ! neurotrophin binding

[Term]
id: GO:0048407
name: platelet-derived growth factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with platelet-derived growth factor." [GOC:dgh]
synonym: "PDGF binding" EXACT []
is_a: GO:0019838 ! growth factor binding

[Term]
id: GO:0048408
name: epidermal growth factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with epidermal growth factor." [GOC:dgh]
synonym: "EGF binding" EXACT []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0048437
name: floral organ development
namespace: biological_process
alt_id: GO:0048433
def: "The process whose specific outcome is the progression of the floral organ over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048569 ! post-embryonic organ development
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0048438
name: floral whorl development
namespace: biological_process
alt_id: GO:0048413
def: "The process whose specific outcome is the progression of a floral whorl over time, from its formation to the mature structure. A floral whorl is a circular arrangement of parts of a flower arising from a stem of a plant." [GOC:dph, GOC:go_curators, GOC:tb]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0048439
name: flower morphogenesis
namespace: biological_process
alt_id: GO:0048411
def: "The process by which the anatomical structures of the flower are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0048440
name: carpel development
namespace: biological_process
alt_id: GO:0048429
def: "The process whose specific outcome is the progression of the carpel over time, from its formation to the mature structure. A carpel is an organ (generally believed to be a modified foliar unit) at the centre of a flower, bearing one or more ovules and having its margins fused together or with other carpels to enclose the ovule in an ovary, and consisting also of a stigma and usually a style." [GOC:go_curators, http://cancerweb.ncl.ac.uk]
is_a: GO:0048437 ! floral organ development
relationship: part_of GO:0048467 ! gynoecium development

[Term]
id: GO:0048441
name: petal development
namespace: biological_process
alt_id: GO:0048417
def: "The process whose specific outcome is the progression of the petal over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048437 ! floral organ development
relationship: part_of GO:0048465 ! corolla development

[Term]
id: GO:0048442
name: sepal development
namespace: biological_process
alt_id: GO:0048421
def: "The process whose specific outcome is the progression of the sepal over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048437 ! floral organ development
relationship: part_of GO:0048464 ! flower calyx development

[Term]
id: GO:0048443
name: stamen development
namespace: biological_process
alt_id: GO:0048425
def: "The process whose specific outcome is the progression of the stamen over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048437 ! floral organ development
relationship: part_of GO:0048466 ! androecium development

[Term]
id: GO:0048444
name: floral organ morphogenesis
namespace: biological_process
alt_id: GO:0048434
def: "The process by which the anatomical structures of the floral organ are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0048563 ! post-embryonic organ morphogenesis
relationship: part_of GO:0048437 ! floral organ development

[Term]
id: GO:0048445
name: carpel morphogenesis
namespace: biological_process
alt_id: GO:0048430
def: "The process by which the anatomical structures of the carpel are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0048444 ! floral organ morphogenesis
relationship: part_of GO:0048440 ! carpel development

[Term]
id: GO:0048446
name: petal morphogenesis
namespace: biological_process
alt_id: GO:0048418
def: "The process by which the anatomical structures of the petal are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0048444 ! floral organ morphogenesis
relationship: part_of GO:0048441 ! petal development

[Term]
id: GO:0048447
name: sepal morphogenesis
namespace: biological_process
alt_id: GO:0048422
def: "The process by which the anatomical structures of the sepal are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0048444 ! floral organ morphogenesis
relationship: part_of GO:0048442 ! sepal development

[Term]
id: GO:0048448
name: stamen morphogenesis
namespace: biological_process
alt_id: GO:0048426
def: "The process by which the anatomical structures of the stamen are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0048444 ! floral organ morphogenesis
relationship: part_of GO:0048443 ! stamen development

[Term]
id: GO:0048449
name: floral organ formation
namespace: biological_process
alt_id: GO:0048436
def: "The process that gives rise to floral organs. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jic]
is_a: GO:0048645 ! organ formation
relationship: part_of GO:0048444 ! floral organ morphogenesis

[Term]
id: GO:0048450
name: floral organ structural organization
namespace: biological_process
alt_id: GO:0048435
def: "The process that contributes to the act of creating the structural organization of floral organs. This process pertains to the physical shaping of a rudimentary structure." [GOC:jic]
synonym: "floral organ structural organisation" EXACT [GOC:curators]
is_a: GO:0048444 ! floral organ morphogenesis
relationship: part_of GO:0048461 ! flower structural organization

[Term]
id: GO:0048451
name: petal formation
namespace: biological_process
alt_id: GO:0048419
def: "The process that gives rise to the petal. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jic]
is_a: GO:0048449 ! floral organ formation
relationship: part_of GO:0048446 ! petal morphogenesis

[Term]
id: GO:0048452
name: petal structural organization
namespace: biological_process
alt_id: GO:0048420
def: "The process that contributes to the act of creating the structural organization of the petal. This process pertains to the physical shaping of a rudimentary structure." [GOC:jic]
synonym: "petal structural organisation" EXACT [GOC:curators]
is_a: GO:0048450 ! floral organ structural organization
relationship: part_of GO:0048446 ! petal morphogenesis

[Term]
id: GO:0048453
name: sepal formation
namespace: biological_process
alt_id: GO:0048423
def: "The process that gives rise to the sepal. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jic]
is_a: GO:0048449 ! floral organ formation
relationship: part_of GO:0048447 ! sepal morphogenesis

[Term]
id: GO:0048454
name: sepal structural organization
namespace: biological_process
alt_id: GO:0048424
def: "The process that contributes to the act of creating the structural organization of the sepal. This process pertains to the physical shaping of a rudimentary structure." [GOC:jic]
synonym: "sepal structural organisation" EXACT [GOC:curators]
is_a: GO:0048450 ! floral organ structural organization
relationship: part_of GO:0048447 ! sepal morphogenesis

[Term]
id: GO:0048455
name: stamen formation
namespace: biological_process
alt_id: GO:0048427
def: "The process that contributes to the act of giving rise to the stamen. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jic]
is_a: GO:0048449 ! floral organ formation
relationship: part_of GO:0048448 ! stamen morphogenesis

[Term]
id: GO:0048456
name: stamen structural organization
namespace: biological_process
alt_id: GO:0048428
def: "The process that contributes to the act of creating the structural organization of the stamen. This process pertains to the physical shaping of a rudimentary structure." [GOC:jic]
synonym: "stamen structural organisation" EXACT [GOC:curators]
is_a: GO:0048450 ! floral organ structural organization
relationship: part_of GO:0048448 ! stamen morphogenesis

[Term]
id: GO:0048457
name: floral whorl morphogenesis
namespace: biological_process
alt_id: GO:0048414
def: "The process by which the anatomical structures of the floral whorl are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0048438 ! floral whorl development
relationship: part_of GO:0048439 ! flower morphogenesis

[Term]
id: GO:0048458
name: floral whorl formation
namespace: biological_process
alt_id: GO:0048415
def: "The process that gives rise to the floral whorl. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jic]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048457 ! floral whorl morphogenesis

[Term]
id: GO:0048459
name: floral whorl structural organization
namespace: biological_process
alt_id: GO:0048416
def: "The process that contributes to the act of creating the structural organization of the floral whorl. This process pertains to the physical shaping of a rudimentary structure." [GOC:jic]
synonym: "floral whorl structural organisation" EXACT [GOC:curators]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0048457 ! floral whorl morphogenesis
relationship: part_of GO:0048461 ! flower structural organization

[Term]
id: GO:0048460
name: flower formation
namespace: biological_process
alt_id: GO:0048410
def: "The process that gives rise to the flower. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jic]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048439 ! flower morphogenesis

[Term]
id: GO:0048461
name: flower structural organization
namespace: biological_process
alt_id: GO:0048412
def: "The process that contributes to the act of creating the structural organization of the flower. This process pertains to the physical shaping of a rudimentary structure." [GOC:jic]
synonym: "flower structural organisation" EXACT [GOC:curators]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0048439 ! flower morphogenesis

[Term]
id: GO:0048462
name: carpel formation
namespace: biological_process
alt_id: GO:0048431
def: "The process that gives rise to the carpel. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jic]
is_a: GO:0048449 ! floral organ formation
relationship: part_of GO:0048445 ! carpel morphogenesis

[Term]
id: GO:0048463
name: carpel structural organization
namespace: biological_process
alt_id: GO:0048432
def: "The process that contributes to the act of creating the structural organization of the carpel. This process pertains to the physical shaping of a rudimentary structure." [GOC:jic]
synonym: "carpel structural organisation" EXACT [GOC:curators]
is_a: GO:0048450 ! floral organ structural organization
relationship: part_of GO:0048445 ! carpel morphogenesis

[Term]
id: GO:0048464
name: flower calyx development
namespace: biological_process
def: "The process whose specific outcome is the progression of the flower calyx over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048438 ! floral whorl development

[Term]
id: GO:0048465
name: corolla development
namespace: biological_process
def: "The process whose specific outcome is the progression of the corolla over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048438 ! floral whorl development

[Term]
id: GO:0048466
name: androecium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the androecium over time, from its formation to the mature structure." [GOC:go_curators]
is_a: GO:0048438 ! floral whorl development

[Term]
id: GO:0048467
name: gynoecium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gynoecium over time, from its formation to the mature structure. The gynoecium is the collective name for the carpels of a flower." [GOC:go_curators, http://cancerweb.ncl.ac.uk]
synonym: "pistil development" EXACT []
is_a: GO:0048438 ! floral whorl development

[Term]
id: GO:0048468
name: cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:go_curators]
subset: goslim_candida
subset: gosubset_prok
synonym: "terminal differentiation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0030154 ! cell differentiation

[Term]
id: GO:0048469
name: cell maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "functional differentiation" RELATED [GOC:dph]
is_a: GO:0021700 ! developmental maturation
is_a: GO:0048869 ! cellular developmental process
relationship: part_of GO:0048468 ! cell development

[Term]
id: GO:0048471
name: perinuclear region of cytoplasm
namespace: cellular_component
def: "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jic]
comment: Note that this term should not be confused with the cellular component term 'nuclear membrane lumen ; GO:0005641', which has the synonym 'perinuclear space'.
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0048472
name: threonine-phosphate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonine O-3-phosphate = (R)-1-aminopropan-2-yl phosphate + CO2." [EC:4.1.1.81, GOC:mlg]
subset: gosubset_prok
synonym: "CobD" RELATED [EC:4.1.1.81]
synonym: "L-threonine O-3-phosphate carboxy-lyase [(R)-1-aminopropan-2-yl-phosphate-forming]" RELATED [EC:4.1.1.81]
synonym: "L-threonine O-3-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.81]
synonym: "L-threonine-O-3-phosphate decarboxylase activity" EXACT []
xref: EC:4.1.1.81
xref: MetaCyc:4.1.1.81-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0048473
name: D-methionine transport
namespace: biological_process
def: "The directed movement of D-methionine into, out of, within, or between cells." [GOC:mlg, PMID:12169620]
subset: gosubset_prok
is_a: GO:0015821 ! methionine transport

[Term]
id: GO:0048474
name: D-methionine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of D-methionine from one side of a membrane to the other." [GOC:mlg, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "D-methionine transporter activity" BROAD []
is_a: GO:0043865 ! methionine transmembrane transporter activity

[Term]
id: GO:0048475
name: coated membrane
namespace: cellular_component
def: "A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes." [GOC:jic]
is_a: GO:0016020 ! membrane

[Term]
id: GO:0048476
name: Holliday junction resolvase complex
namespace: cellular_component
def: "A protein complex that mediates the conversion of a Holliday junction into two separate duplex DNA molecules; the complex includes a single- or multisubunit helicase that catalyzes the extension of heteroduplex DNA by branch migration and a nuclease that resolves the junction by nucleolytic cleavage." [PMID:11207366, PMID:12374758]
subset: goslim_pir
synonym: "Mus81-Eme1 complex" NARROW []
synonym: "resolvasome" EXACT [PMID:11207366]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0048477
name: oogenesis
namespace: biological_process
alt_id: GO:0009993
alt_id: GO:0048157
def: "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu]
synonym: "ovum development" EXACT systematic_synonym []
xref: Wikipedia:Oogenesis
is_a: GO:0007292 ! female gamete generation

[Term]
id: GO:0048478
name: replication fork protection
namespace: biological_process
def: "Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029]
synonym: "replication fork maintenance" BROAD []
synonym: "replication fork stabilization" BROAD []
is_a: GO:0008156 ! negative regulation of DNA replication
is_a: GO:0045005 ! maintenance of fidelity during DNA-dependent DNA replication

[Term]
id: GO:0048479
name: style development
namespace: biological_process
def: "The process whose specific outcome is the progression of the style over time, from its formation to the mature structure. The style is an elongated part of a carpel, or group of fused carpels, and it lies between the ovary and the stigma." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048440 ! carpel development

[Term]
id: GO:0048480
name: stigma development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stigma over time, from its formation to the mature structure. The stigma is the pollen-receptive surface of a carpel or group of fused carpels, usually sticky." [GOC:jic, http://cancerweb.ncl.ac.uk]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048440 ! carpel development

[Term]
id: GO:0048481
name: ovule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed." [GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048440 ! carpel development

[Term]
id: GO:0048482
name: ovule morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the ovule are generated and organized. Morphogenesis pertains to the creation of form. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed." [GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048445 ! carpel morphogenesis
relationship: part_of GO:0048481 ! ovule development

[Term]
id: GO:0048483
name: autonomic nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands." [GOC:jic, GOC:sr, http://cancerweb.ncl.ac.uk]
is_a: GO:0048731 ! system development
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0048484
name: enteric nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation." [GOC:jic, GOC:sr, http://cancerweb.ncl.ac.uk]
is_a: GO:0048731 ! system development
relationship: part_of GO:0048483 ! autonomic nervous system development

[Term]
id: GO:0048485
name: sympathetic nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter." [GOC:jic, GOC:sr, http://cancerweb.ncl.ac.uk]
is_a: GO:0048731 ! system development
relationship: part_of GO:0048483 ! autonomic nervous system development

[Term]
id: GO:0048486
name: parasympathetic nervous system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [GOC:jic, GOC:sr, http://cancerweb.ncl.ac.uk]
is_a: GO:0048731 ! system development
relationship: part_of GO:0048483 ! autonomic nervous system development

[Term]
id: GO:0048487
name: beta-tubulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin." [GOC:krc]
synonym: "beta tubulin binding" EXACT []
is_a: GO:0015631 ! tubulin binding

[Term]
id: GO:0048488
name: synaptic vesicle endocytosis
namespace: biological_process
alt_id: GO:0008099
def: "Invagination of the axonal plasma membrane creating a membrane-bounded vesicle. Without this process the presynaptic terminal would swell up due to fusion of vesicle membranes during neurotransmitter release. The vesicles created may subsequently be used for neurotransmitter storage/release." [GOC:jic, GOC:lmg]
subset: gosubset_prok
synonym: "synaptic vesicle retrieval" RELATED []
is_a: GO:0006897 ! endocytosis
is_a: GO:0048489 ! synaptic vesicle transport

[Term]
id: GO:0048489
name: synaptic vesicle transport
namespace: biological_process
alt_id: GO:0016181
def: "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron along the cytoskeleton either toward or away from the neuronal cell body." [GOC:jic, GOC:lmg]
subset: gosubset_prok
synonym: "synaptic vesicle fission" RELATED []
synonym: "synaptic vesicle fusion" RELATED []
is_a: GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0048490
name: anterograde synaptic vesicle transport
namespace: biological_process
def: "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron, along the cytoskeleton, away from the neuronal cell body." [GOC:jic, GOC:lmg]
is_a: GO:0048489 ! synaptic vesicle transport

[Term]
id: GO:0048491
name: retrograde synaptic vesicle transport
namespace: biological_process
def: "The directed movement of substances in synaptic membrane-bounded vesicles within the neuron, along the cytoskeleton, toward the neuronal cell body." [GOC:jic, GOC:lmg]
is_a: GO:0048489 ! synaptic vesicle transport

[Term]
id: GO:0048492
name: ribulose bisphosphate carboxylase complex
namespace: cellular_component
def: "A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg]
subset: goslim_pir
subset: gosubset_prok
synonym: "RubisCO complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0048493
name: plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex
namespace: cellular_component
def: "A complex, located in the plasma membrane-derived thylakoid, containing either both large and small subunits or just small subunits. It carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "plasma membrane ribulose bisphosphate carboxylase complex" EXACT []
synonym: "ribulose bisphosphate carboxylase complex" BROAD []
synonym: "RubisCO complex" BROAD []
is_a: GO:0044436 ! thylakoid part
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0048494 ! chromatophore ribulose bisphosphate carboxylase complex
relationship: part_of GO:0030075 ! plasma membrane-derived thylakoid

[Term]
id: GO:0048494
name: chromatophore ribulose bisphosphate carboxylase complex
namespace: cellular_component
def: "A complex, located in the chromatophore, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu]
subset: gosubset_prok
synonym: "RubisCO complex" BROAD []
is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex
relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore

[Term]
id: GO:0048495
name: Roundabout binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the Roundabout (ROBO) receptor, a transmembrane receptor." [GOC:ecd, PMID:10102268, PMID:10197527]
synonym: "Roundabout receptor binding" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0048496
name: maintenance of organ identity
namespace: biological_process
def: "The process by which the identity of an organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators, PMID:9090883]
is_a: GO:0045596 ! negative regulation of cell differentiation
relationship: part_of GO:0048513 ! organ development

[Term]
id: GO:0048497
name: maintenance of floral organ identity
namespace: biological_process
def: "The process by which the identity of a floral organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators, PMID:9090883]
is_a: GO:0048496 ! maintenance of organ identity
relationship: part_of GO:0048437 ! floral organ development

[Term]
id: GO:0048498
name: establishment of petal orientation
namespace: biological_process
def: "The process that determines the orientation of petals with reference to the central axis." [GOC:tb, PMID:10572040]
is_a: GO:0048559 ! establishment of floral organ orientation
relationship: part_of GO:0048446 ! petal morphogenesis

[Term]
id: GO:0048499
name: synaptic vesicle membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle." [GOC:dph, GOC:jl, GOC:mah, PMID:10620806]
synonym: "SLMV biogenesis" NARROW []
synonym: "synaptic vesicle membrane organisation" EXACT [GOC:curators]
synonym: "synaptic vesicle membrane organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016044 ! cellular membrane organization

[Term]
id: GO:0048500
name: signal recognition particle
namespace: cellular_component
def: "A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Signal_recognition_particle
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0048501
name: signal recognition particle, plasma membrane targeting
namespace: cellular_component
def: "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to or across the plasma membrane." [GOC:mlg, GOC:mtg_sensu]
subset: gosubset_prok
is_a: GO:0048500 ! signal recognition particle

[Term]
id: GO:0048502
name: thiamin-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O + thiamin(out) = ADP + phosphate + thiamin(in)." [GOC:mlg, PMID:9535878]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "thiamin ABC transporter" NARROW []
synonym: "thiamine-transporting ATPase activity" EXACT []
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0048503
name: GPI anchor binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw]
comment: This term was made obsolete because it has been widely, and incorrectly, used to annotate proteins that have GPI anchors covalently attached. A new term has been created that can be used to annotate gene products that interact non-covalently with GPI anchors.
synonym: "glycosylphosphatidylinositol binding" EXACT []
is_obsolete: true

[Term]
id: GO:0048504
name: regulation of timing of organ formation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of organ formation at a consistent predetermined time point during development." [GOC:bf, GOC:dph, GOC:jic, GOC:tb]
synonym: "timing of organ biosynthesis" RELATED []
synonym: "timing of organ formation" RELATED []
is_a: GO:0003156 ! regulation of organ formation
is_a: GO:0040034 ! regulation of development, heterochronic

[Term]
id: GO:0048505
name: regulation of timing of cell differentiation
namespace: biological_process
def: "The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development." [GOC:bf, GOC:dph, GOC:jic, GOC:tb]
synonym: "timing of cell differentiation" RELATED []
is_a: GO:0040034 ! regulation of development, heterochronic
is_a: GO:0045595 ! regulation of cell differentiation

[Term]
id: GO:0048506
name: regulation of timing of meristematic phase transition
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a change in identity of a meristem at a characteristic predetermined time point." [GOC:dph, GOC:jic, GOC:tb]
is_a: GO:0040034 ! regulation of development, heterochronic
is_a: GO:0048509 ! regulation of meristem development

[Term]
id: GO:0048507
name: meristem development
namespace: biological_process
def: "The process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure." [GOC:jic]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0048508
name: embryonic meristem development
namespace: biological_process
def: "The process whose specific outcome is the progression of the embryonic meristem over time, from its formation to the mature structure." [GOC:jic]
is_a: GO:0048507 ! meristem development
relationship: part_of GO:0009793 ! embryonic development ending in seed dormancy

[Term]
id: GO:0048509
name: regulation of meristem development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of meristem development, the biological process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure." [GOC:jic]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0048507 ! meristem development

[Term]
id: GO:0048510
name: regulation of timing of transition from vegetative to reproductive phase
namespace: biological_process
def: "The process controlling the point in time during development when a vegetative meristem will change its identity to become an inflorescence or floral meristem, and/or the rate at which the change occurs." [GOC:jic, PMID:8974397]
is_a: GO:0048506 ! regulation of timing of meristematic phase transition

[Term]
id: GO:0048511
name: rhythmic process
namespace: biological_process
def: "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jic]
subset: goslim_pir
subset: gosubset_prok
synonym: "rhythm" RELATED []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0048512
name: circadian behavior
namespace: biological_process
def: "The specific actions or reactions of an organism that recur with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators]
synonym: "circadian rhythm behavior" EXACT []
is_a: GO:0007622 ! rhythmic behavior
is_a: GO:0007623 ! circadian rhythm

[Term]
id: GO:0048513
name: organ development
namespace: biological_process
def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jic]
synonym: "development of an organ" EXACT []
synonym: "organogenesis" EXACT []
xref: Wikipedia:Organogenesis
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048731 ! system development

[Term]
id: GO:0048514
name: blood vessel morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood." [GOC:jic]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0001568 ! blood vessel development

[Term]
id: GO:0048515
name: spermatid differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a spermatid cell." [GOC:jic]
synonym: "spermatid cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007283 ! spermatogenesis

[Term]
id: GO:0048516
name: trichome initiation (sensu Magnoliophyta)
namespace: biological_process
def: "OBSOLETE. Processes causing the differentiation of an epidermal cell into a trichome cell; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:lr]
comment: This term was made obsolete because more appropriate terms were created.
is_obsolete: true
consider: GO:0048629

[Term]
id: GO:0048517
name: positive regulation of trichome initiation (sensu Magnoliophyta)
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of trichome initiation; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:lr]
comment: This term was made obsolete because more appropriate terms were created.
is_obsolete: true
consider: GO:0048629

[Term]
id: GO:0048518
name: positive regulation of biological process
namespace: biological_process
alt_id: GO:0043119
def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jic]
subset: gosubset_prok
synonym: "activation of biological process" NARROW []
synonym: "positive regulation of physiological process" EXACT []
synonym: "stimulation of biological process" NARROW []
synonym: "up regulation of biological process" EXACT []
synonym: "up-regulation of biological process" EXACT []
synonym: "upregulation of biological process" EXACT []
is_a: GO:0050789 ! regulation of biological process
relationship: positively_regulates GO:0008150 ! biological_process

[Term]
id: GO:0048519
name: negative regulation of biological process
namespace: biological_process
alt_id: GO:0043118
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jic]
subset: gosubset_prok
synonym: "down regulation of biological process" EXACT []
synonym: "down-regulation of biological process" EXACT []
synonym: "downregulation of biological process" EXACT []
synonym: "inhibition of biological process" NARROW []
synonym: "negative regulation of physiological process" EXACT []
is_a: GO:0050789 ! regulation of biological process
relationship: negatively_regulates GO:0008150 ! biological_process

[Term]
id: GO:0048520
name: positive regulation of behavior
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli." [GOC:jic]
synonym: "activation of behavior" NARROW []
synonym: "stimulation of behavior" NARROW []
synonym: "up regulation of behavior" EXACT []
synonym: "up-regulation of behavior" EXACT []
synonym: "upregulation of behavior" EXACT []
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0050795 ! regulation of behavior
relationship: positively_regulates GO:0007610 ! behavior

[Term]
id: GO:0048521
name: negative regulation of behavior
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli." [GOC:jic]
synonym: "down regulation of behavior" EXACT []
synonym: "down-regulation of behavior" EXACT []
synonym: "downregulation of behavior" EXACT []
synonym: "inhibition of behavior" NARROW []
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0050795 ! regulation of behavior
relationship: negatively_regulates GO:0007610 ! behavior

[Term]
id: GO:0048522
name: positive regulation of cellular process
namespace: biological_process
alt_id: GO:0051242
def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jic]
subset: gosubset_prok
synonym: "activation of cellular process" NARROW []
synonym: "positive regulation of cellular physiological process" EXACT []
synonym: "stimulation of cellular process" NARROW []
synonym: "up regulation of cellular process" EXACT []
synonym: "up-regulation of cellular process" EXACT []
synonym: "upregulation of cellular process" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0050794 ! regulation of cellular process
relationship: positively_regulates GO:0009987 ! cellular process

[Term]
id: GO:0048523
name: negative regulation of cellular process
namespace: biological_process
alt_id: GO:0051243
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jic]
subset: gosubset_prok
synonym: "down regulation of cellular process" EXACT []
synonym: "down-regulation of cellular process" EXACT []
synonym: "downregulation of cellular process" EXACT []
synonym: "inhibition of cellular process" NARROW []
synonym: "negative regulation of cellular physiological process" EXACT []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050794 ! regulation of cellular process
relationship: negatively_regulates GO:0009987 ! cellular process

[Term]
id: GO:0048524
name: positive regulation of viral reproduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:jic, GOC:tb]
synonym: "activation of viral life cycle" NARROW []
synonym: "positive regulation of viral life cycle" EXACT [GOC:tb]
synonym: "stimulation of viral life cycle" NARROW []
synonym: "up regulation of viral life cycle" EXACT []
synonym: "up-regulation of viral life cycle" EXACT []
synonym: "upregulation of viral life cycle" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0050792 ! regulation of viral reproduction
relationship: positively_regulates GO:0016032 ! viral reproduction

[Term]
id: GO:0048525
name: negative regulation of viral reproduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:jic, GOC:tb]
synonym: "down regulation of viral life cycle" EXACT []
synonym: "down-regulation of viral life cycle" EXACT []
synonym: "downregulation of viral life cycle" EXACT []
synonym: "inhibition of viral life cycle" NARROW []
synonym: "negative regulation of viral life cycle" EXACT [GOC:tb]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050792 ! regulation of viral reproduction
relationship: negatively_regulates GO:0016032 ! viral reproduction

[Term]
id: GO:0048526
name: imaginal disc-derived wing expansion
namespace: biological_process
def: "The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing." [GOC:mtg_sensu, GOC:rc]
synonym: "wing expansion" EXACT []
synonym: "wing inflation" EXACT []
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0048527
name: lateral root development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral root over time, from its formation to the mature structure. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper." [GOC:tb]
is_a: GO:0048364 ! root development
is_a: GO:0048528 ! post-embryonic root development

[Term]
id: GO:0048528
name: post-embryonic root development
namespace: biological_process
def: "The process whose specific outcome is the progression of the post-embryonic root over time, from its formation to the mature structure." [GOC:tb]
is_a: GO:0009791 ! post-embryonic development

[Term]
id: GO:0048529
name: magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O." [EC:1.14.13.81]
synonym: "magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.81]
synonym: "Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase activity" EXACT [EC:1.14.13.81]
synonym: "Mg-protoporphyrin IX monomethyl ester oxidative cyclase activity" EXACT [EC:1.14.13.81]
xref: EC:1.14.13.81
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0048530
name: fruit morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a fruit are generated and organized. Morphogenesis pertains to the creation of form. A fruit is a reproductive body of a seed plant." [GOC:sm]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0010154 ! fruit development

[Term]
id: GO:0048531
name: beta-1,3-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage." [PMID:11551958]
is_a: GO:0008378 ! galactosyltransferase activity

[Term]
id: GO:0048532
name: anatomical structure arrangement
namespace: biological_process
def: "The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:go_curators]
synonym: "anatomical structure organization" BROAD []
synonym: "anatomical structure structural organization" EXACT []
synonym: "organization of an anatomical structure" EXACT []
synonym: "structural organization" EXACT []
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0048533
name: sporocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized floral cell acquires the specialized features of a sporocyte. Sporocytes are the haploid spores of angiosperms. Once formed, they undergo meiotic divisions to form microspores and megaspores." [GOC:tair_curators]
synonym: "sporocyte development" NARROW []
synonym: "sporocyte morphogenesis" RELATED []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0048534
name: hemopoietic or lymphoid organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of any organ involved in hemopoiesis or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "haematopoietic or lymphoid organ development" EXACT []
synonym: "haemopoietic or lymphoid organ development" EXACT []
synonym: "hematopoietic or lymphoid organ development" EXACT []
is_a: GO:0048513 ! organ development
relationship: part_of GO:0002520 ! immune system development

[Term]
id: GO:0048535
name: lymph node development
namespace: biological_process
def: "The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary", ISBN:0781735149 "Fundamental Immunology"]
synonym: "lymph gland development" BROAD []
is_a: GO:0048534 ! hemopoietic or lymphoid organ development

[Term]
id: GO:0048536
name: spleen development
namespace: biological_process
def: "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0048534 ! hemopoietic or lymphoid organ development

[Term]
id: GO:0048537
name: mucosal-associated lymphoid tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of mucosal- associated lymphoid tissue over time, from its formation to the mature structure. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "BALT development" NARROW []
synonym: "bronchial-associated lymphoid tissue development" NARROW []
synonym: "GALT development" NARROW []
synonym: "gut-associated lymphoid tissue development" NARROW []
synonym: "NALT development" NARROW []
synonym: "nasopharyngeal-associated lymphoid tissue development" NARROW []
is_a: GO:0048534 ! hemopoietic or lymphoid organ development

[Term]
id: GO:0048538
name: thymus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
comment: Note that this term is reserved for annotation of gene products involved in the formation of the thymus itself, not for gene products involved in T cell differentiation in the thymus or elsewhere.
is_a: GO:0048534 ! hemopoietic or lymphoid organ development

[Term]
id: GO:0048539
name: bone marrow development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0048534 ! hemopoietic or lymphoid organ development
relationship: part_of GO:0060348 ! bone development

[Term]
id: GO:0048540
name: bursa of Fabricius development
namespace: biological_process
def: "The process whose specific outcome is the progression of the bursa of Fabricius over time, from its formation to the mature structure. The bursa of Fabricius is an organ found in birds involved in B cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
is_a: GO:0048534 ! hemopoietic or lymphoid organ development

[Term]
id: GO:0048541
name: Peyer's patch development
namespace: biological_process
def: "The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"]
synonym: "GALT development" RELATED []
synonym: "gut-associated lymphoid tissue development" RELATED []
is_a: GO:0048537 ! mucosal-associated lymphoid tissue development

[Term]
id: GO:0048542
name: lymph gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc]
synonym: "haematopoietic organ development" BROAD []
synonym: "haemopoietic organ development" BROAD []
synonym: "hematopoietic organ development" BROAD []
synonym: "hemopoietic organ development" BROAD []
is_a: GO:0048534 ! hemopoietic or lymphoid organ development
is_a: GO:0048732 ! gland development

[Term]
id: GO:0048543
name: phytochrome chromophore biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the phytochrome chromophore. The phytochrome chromophore is a linear tetrapyrrolic prosthetic group covalently attached to the large soluble protein phytochrome. Light absorption by the phytochrome chromophore triggers photoconversion between two spectrally distinct forms of the photoreceptor: Pr, the red light absorbing form, and Pfr, the far red light absorbing form." [GOC:pj, PMID:2909515]
synonym: "phytochrome chromophore anabolism" EXACT []
synonym: "phytochrome chromophore biosynthesis" EXACT []
synonym: "phytochrome chromophore formation" EXACT []
synonym: "phytochrome chromophore synthesis" EXACT []
is_a: GO:0046148 ! pigment biosynthetic process

[Term]
id: GO:0048544
name: recognition of pollen
namespace: biological_process
alt_id: GO:0009857
def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species." [GOC:dph, GOC:pj, GOC:tb]
synonym: "pollen recognition" EXACT []
synonym: "recognition or rejection of self pollen" RELATED [GOC:dph, GOC:tb]
synonym: "self incompatibility" RELATED []
is_a: GO:0008037 ! cell recognition
relationship: part_of GO:0009875 ! pollen-pistil interaction

[Term]
id: GO:0048545
name: response to steroid hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators]
is_a: GO:0009725 ! response to hormone stimulus

[Term]
id: GO:0048546
name: digestive tract morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the tube extending from the mouth to the anus, including the pharynx, esophagus, stomach, and intestines." [GOC:go_curators, PMID:12618131]
synonym: "alimentary canal morphogenesis" EXACT []
synonym: "digestive tube morphogenesis" EXACT []
synonym: "gastrointestinal tract morphogenesis" EXACT []
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0055123 ! digestive system development

[Term]
id: GO:0048547
name: gut morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the gut are generated and organized. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus." [GOC:go_curators, PMID:12618131]
synonym: "intestinal morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048546 ! digestive tract morphogenesis
relationship: part_of GO:0048565 ! gut development

[Term]
id: GO:0048548
name: regulation of pinocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pinocytosis. Pinocytosis is the process whereby cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators]
is_a: GO:0030100 ! regulation of endocytosis
relationship: regulates GO:0006907 ! pinocytosis

[Term]
id: GO:0048549
name: positive regulation of pinocytosis
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process whereby cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators]
synonym: "activation of pinocytosis" NARROW []
synonym: "stimulation of pinocytosis" NARROW []
synonym: "up regulation of pinocytosis" EXACT []
synonym: "up-regulation of pinocytosis" EXACT []
synonym: "upregulation of pinocytosis" EXACT []
is_a: GO:0045807 ! positive regulation of endocytosis
is_a: GO:0048548 ! regulation of pinocytosis
relationship: positively_regulates GO:0006907 ! pinocytosis

[Term]
id: GO:0048550
name: negative regulation of pinocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process whereby cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators]
synonym: "down regulation of pinocytosis" EXACT []
synonym: "down-regulation of pinocytosis" EXACT []
synonym: "downregulation of pinocytosis" EXACT []
synonym: "inhibition of pinocytosis" NARROW []
is_a: GO:0045806 ! negative regulation of endocytosis
is_a: GO:0048548 ! regulation of pinocytosis
relationship: negatively_regulates GO:0006907 ! pinocytosis

[Term]
id: GO:0048551
name: metalloenzyme inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:ebc]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0010576 ! metalloenzyme regulator activity

[Term]
id: GO:0048552
name: regulation of metalloenzyme activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:ebc]
subset: gosubset_prok
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0048553
name: negative regulation of metalloenzyme activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:ebc]
synonym: "down regulation of metalloenzyme activity" EXACT []
synonym: "down-regulation of metalloenzyme activity" EXACT []
synonym: "downregulation of metalloenzyme activity" EXACT []
synonym: "inhibition of metalloenzyme activity" NARROW []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0048552 ! regulation of metalloenzyme activity

[Term]
id: GO:0048554
name: positive regulation of metalloenzyme activity
namespace: biological_process
def: "Any process that activates, maintains or increases the rate activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal." [GOC:ebc]
synonym: "activation of metalloenzyme activity" NARROW []
synonym: "stimulation of metalloenzyme activity" NARROW []
synonym: "up regulation of metalloenzyme activity" EXACT []
synonym: "up-regulation of metalloenzyme activity" EXACT []
synonym: "upregulation of metalloenzyme activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0048552 ! regulation of metalloenzyme activity

[Term]
id: GO:0048555
name: generative cell nucleus
namespace: cellular_component
def: "The nucleus of the generative cell, a cell contained within the pollen grain that will divide to produce two haploid sperm cells." [GOC:tair_curators]
synonym: "male germ cell nucleus" BROAD []
synonym: "sperm cell nucleus" BROAD []
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0048556
name: microsporocyte nucleus
namespace: cellular_component
alt_id: GO:0043074
def: "The nucleus of the microsporocyte. The microsporocyte is a diploid cell in which meiosis will occur, resulting in four microspores. A microspore is a spore that, in vascular plants, gives rise to a male gametophyte." [GOC:tair_curators, ISBN:047186840X]
synonym: "microspore mother cell nucleus" EXACT []
synonym: "pollen mother cell nucleus" EXACT []
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0048557
name: embryonic digestive tract morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the tube extending from the mouth to the anus, including the pharynx, esophagus, stomach, and intestines." [GOC:go_curators]
is_a: GO:0048546 ! digestive tract morphogenesis
is_a: GO:0048562 ! embryonic organ morphogenesis

[Term]
id: GO:0048558
name: embryonic gut morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the gut are generated and organized during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus." [GOC:go_curators]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048547 ! gut morphogenesis
relationship: part_of GO:0048557 ! embryonic digestive tract morphogenesis
relationship: part_of GO:0048566 ! embryonic gut development

[Term]
id: GO:0048559
name: establishment of floral organ orientation
namespace: biological_process
def: "The process that determines the orientation of the floral organs with reference to the central axis of the flower." [GOC:jic]
is_a: GO:0048561 ! establishment of organ orientation
relationship: part_of GO:0048439 ! flower morphogenesis

[Term]
id: GO:0048560
name: establishment of anatomical structure orientation
namespace: biological_process
def: "The process that determines the orientation of an anatomical structure with reference to an axis." [GOC:jic]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0048561
name: establishment of organ orientation
namespace: biological_process
def: "The process that determines the orientation of an organ or tissue with reference to an axis." [GOC:jic]
is_a: GO:0048560 ! establishment of anatomical structure orientation
relationship: part_of GO:0009887 ! organ morphogenesis

[Term]
id: GO:0048562
name: embryonic organ morphogenesis
namespace: biological_process
def: "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jic]
is_a: GO:0009887 ! organ morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048568 ! embryonic organ development

[Term]
id: GO:0048563
name: post-embryonic organ morphogenesis
namespace: biological_process
def: "Morphogenesis, during the post-embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jic]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0048569 ! post-embryonic organ development

[Term]
id: GO:0048564
name: photosystem I assembly
namespace: biological_process
alt_id: GO:0010251
def: "The aggregation, arrangement and bonding together of a set of components to form a photosystem I complex on the thylakoid membrane." [GOC:go_curators]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0019684 ! photosynthesis, light reaction

[Term]
id: GO:0048565
name: gut development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus." [GOC:go_curators]
synonym: "intestinal development" EXACT []
synonym: "intestine development" EXACT []
is_a: GO:0048513 ! organ development

[Term]
id: GO:0048566
name: embryonic gut development
namespace: biological_process
def: "The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus." [GOC:go_curators]
is_a: GO:0048565 ! gut development
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:0048567
name: ectodermal gut morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the ectodermal gut are generated and organized. Morphogenesis pertains to the creation of form. The ectodermal gut includes those portions of the gut that are derived from ectoderm." [GOC:jic]
is_a: GO:0007439 ! ectodermal gut development
is_a: GO:0048547 ! gut morphogenesis

[Term]
id: GO:0048568
name: embryonic organ development
namespace: biological_process
def: "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jic]
synonym: "embryonic organogenesis" EXACT []
is_a: GO:0048513 ! organ development
relationship: part_of GO:0009790 ! embryonic development

[Term]
id: GO:0048569
name: post-embryonic organ development
namespace: biological_process
def: "Development, taking place during the post-embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jic]
synonym: "post-embryonic organogenesis" EXACT []
is_a: GO:0048513 ! organ development

[Term]
id: GO:0048570
name: notochord morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the notochord are generated and organized. Morphogenesis pertains to the creation of form. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:jic]
is_a: GO:0048562 ! embryonic organ morphogenesis
relationship: part_of GO:0030903 ! notochord development

[Term]
id: GO:0048571
name: long-day photoperiodism
namespace: biological_process
def: "A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that exceeds a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 hours minus the critical day length." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "response to long-day" EXACT []
synonym: "response to long-day photoperiod" RELATED []
synonym: "response to short-night" EXACT []
synonym: "short-night photoperiodism" EXACT []
is_a: GO:0009648 ! photoperiodism

[Term]
id: GO:0048572
name: short-day photoperiodism
namespace: biological_process
def: "A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that falls short of a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 hours minus the critical day length." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "long-night photoperiodism" EXACT []
synonym: "response to long-night" EXACT []
synonym: "response to short-day" EXACT []
synonym: "response to short-day photoperiod" RELATED []
is_a: GO:0009648 ! photoperiodism

[Term]
id: GO:0048573
name: photoperiodism, flowering
namespace: biological_process
def: "A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light or dark of a given length. The length of the period of light or dark required to initiate the change is set relative to a particular duration known as the 'critical day length'. The critical day length varies between species." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "photoperiodic control of flowering time" EXACT []
synonym: "photoperiodic control of inflorescence development" EXACT []
synonym: "response to day length, flowering" EXACT []
synonym: "response to night length, flowering" EXACT []
synonym: "response to photoperiod, flowering" EXACT []
is_a: GO:0009648 ! photoperiodism
relationship: part_of GO:0010228 ! vegetative to reproductive phase transition of meristem

[Term]
id: GO:0048574
name: long-day photoperiodism, flowering
namespace: biological_process
def: "A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light that exceeds the critical day length. The critical day length varies between species. Although the term is long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 minus the critical day length." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "long-day photoperiodic control of flowering" EXACT []
synonym: "long-day photoperiodic control of flowering time" EXACT []
synonym: "long-day photoperiodic control of inflorescence development" EXACT []
synonym: "response to long-day, flowering" EXACT []
synonym: "response to short-night, flowering" EXACT []
synonym: "short-night photoperiodism, flowering" EXACT []
is_a: GO:0048571 ! long-day photoperiodism
is_a: GO:0048573 ! photoperiodism, flowering

[Term]
id: GO:0048575
name: short-day photoperiodism, flowering
namespace: biological_process
def: "A change from vegetative to reproductive phase as a result of detection of, or exposure to, a period of light that falls short of the critical day length. The critical day length varies between species. Although the term is short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 minus the critical day length." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "long-night photoperiodism, flowering" EXACT []
synonym: "response to long-night, flowering" EXACT []
synonym: "response to short-day, flowering" EXACT []
synonym: "short-day photoperiodic control of flowering" EXACT []
synonym: "short-day photoperiodic control of flowering time" EXACT []
synonym: "short-day photoperiodic control of inflorescence development" EXACT []
is_a: GO:0048572 ! short-day photoperiodism
is_a: GO:0048573 ! photoperiodism, flowering

[Term]
id: GO:0048576
name: positive regulation of short-day photoperiodism, flowering
namespace: biological_process
def: "Any process that activates, maintains or increases short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "activation of short-day photoperiodism, flowering" NARROW []
synonym: "stimulation of short-day photoperiodism, flowering" NARROW []
synonym: "up regulation of short-day photoperiodism, flowering" EXACT []
synonym: "up-regulation of short-day photoperiodism, flowering" EXACT []
synonym: "upregulation of short-day photoperiodism, flowering" EXACT []
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0048587 ! regulation of short-day photoperiodism, flowering
relationship: positively_regulates GO:0048575 ! short-day photoperiodism, flowering

[Term]
id: GO:0048577
name: negative regulation of short-day photoperiodism, flowering
namespace: biological_process
def: "Any process that stops, prevents or reduces short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "down regulation of short-day photoperiodism, flowering" EXACT []
synonym: "down-regulation of short-day photoperiodism, flowering" EXACT []
synonym: "downregulation of short-day photoperiodism, flowering" EXACT []
synonym: "inhibition of short-day photoperiodism, flowering" NARROW []
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0048587 ! regulation of short-day photoperiodism, flowering
relationship: negatively_regulates GO:0048575 ! short-day photoperiodism, flowering

[Term]
id: GO:0048578
name: positive regulation of long-day photoperiodism, flowering
namespace: biological_process
def: "Any process that activates, maintains or increases long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "activation of long-day photoperiodism, flowering" NARROW []
synonym: "stimulation of long-day photoperiodism, flowering" NARROW []
synonym: "up regulation of long-day photoperiodism, flowering" EXACT []
synonym: "up-regulation of long-day photoperiodism, flowering" EXACT []
synonym: "upregulation of long-day photoperiodism, flowering" EXACT []
is_a: GO:0048582 ! positive regulation of post-embryonic development
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0048586 ! regulation of long-day photoperiodism, flowering
relationship: positively_regulates GO:0048574 ! long-day photoperiodism, flowering

[Term]
id: GO:0048579
name: negative regulation of long-day photoperiodism, flowering
namespace: biological_process
def: "Any process that stops, prevents or reduces long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
synonym: "down regulation of long-day photoperiodism, flowering" EXACT []
synonym: "down-regulation of long-day photoperiodism, flowering" EXACT []
synonym: "downregulation of long-day photoperiodism, flowering" EXACT []
synonym: "inhibition of long-day photoperiodism, flowering" NARROW []
is_a: GO:0048581 ! negative regulation of post-embryonic development
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0048586 ! regulation of long-day photoperiodism, flowering
relationship: negatively_regulates GO:0048574 ! long-day photoperiodism, flowering

[Term]
id: GO:0048580
name: regulation of post-embryonic development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jic]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0009791 ! post-embryonic development

[Term]
id: GO:0048581
name: negative regulation of post-embryonic development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jic]
synonym: "down regulation of post-embryonic development" EXACT []
synonym: "down-regulation of post-embryonic development" EXACT []
synonym: "downregulation of post-embryonic development" EXACT []
synonym: "inhibition of post-embryonic development" NARROW []
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0009791 ! post-embryonic development

[Term]
id: GO:0048582
name: positive regulation of post-embryonic development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jic]
synonym: "activation of post-embryonic development" NARROW []
synonym: "stimulation of post-embryonic development" NARROW []
synonym: "up regulation of post-embryonic development" EXACT []
synonym: "up-regulation of post-embryonic development" EXACT []
synonym: "upregulation of post-embryonic development" EXACT []
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0009791 ! post-embryonic development

[Term]
id: GO:0048583
name: regulation of response to stimulus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jic]
subset: gosubset_prok
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0050896 ! response to stimulus

[Term]
id: GO:0048584
name: positive regulation of response to stimulus
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jic]
synonym: "activation of response to stimulus" NARROW []
synonym: "stimulation of response to stimulus" NARROW []
synonym: "up regulation of response to stimulus" EXACT []
synonym: "up-regulation of response to stimulus" EXACT []
synonym: "upregulation of response to stimulus" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0048583 ! regulation of response to stimulus
relationship: positively_regulates GO:0050896 ! response to stimulus

[Term]
id: GO:0048585
name: negative regulation of response to stimulus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jic]
synonym: "down regulation of response to stimulus" EXACT []
synonym: "down-regulation of response to stimulus" EXACT []
synonym: "downregulation of response to stimulus" EXACT []
synonym: "inhibition of response to stimulus" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0048583 ! regulation of response to stimulus
relationship: negatively_regulates GO:0050896 ! response to stimulus

[Term]
id: GO:0048586
name: regulation of long-day photoperiodism, flowering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0048574 ! long-day photoperiodism, flowering

[Term]
id: GO:0048587
name: regulation of short-day photoperiodism, flowering
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jic, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862]
is_a: GO:0048580 ! regulation of post-embryonic development
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0048575 ! short-day photoperiodism, flowering

[Term]
id: GO:0048588
name: developmental cell growth
namespace: biological_process
def: "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete]
synonym: "developmental growth of a unicellular organism" EXACT []
is_a: GO:0016049 ! cell growth
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0048468 ! cell development

[Term]
id: GO:0048589
name: developmental growth
namespace: biological_process
def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators]
is_a: GO:0032502 ! developmental process
is_a: GO:0040007 ! growth

[Term]
id: GO:0048590
name: non-developmental growth
namespace: biological_process
def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass is does not have the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators]
is_a: GO:0040007 ! growth

[Term]
id: GO:0048591
name: non-developmental cell growth
namespace: biological_process
def: "The growth of a cell prior to division, where the growth does not change the cell from one condition to another condition over time." [GOC:go_curators, GOC:isa_complete]
synonym: "non-developmental growth of a unicellular organism" EXACT []
is_a: GO:0016049 ! cell growth
is_a: GO:0048590 ! non-developmental growth

[Term]
id: GO:0048592
name: eye morphogenesis
namespace: biological_process
alt_id: GO:0048748
def: "The process by which the anatomical structures of the eye are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:mtg_sensu]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0001654 ! eye development

[Term]
id: GO:0048593
name: camera-type eye morphogenesis
namespace: biological_process
alt_id: GO:0048594
alt_id: GO:0048595
def: "The process by which the anatomical structures of the eye are generated and organized. Morphogenesis pertains to the creation of form. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:jic, GOC:mtg_sensu]
synonym: "camera-style eye morphogenesis" EXACT [GOC:dph]
is_a: GO:0048592 ! eye morphogenesis
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0048596
name: embryonic camera-type eye morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the eye are generated and organized during embryonic development. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:mtg_sensu]
synonym: "embryonic eye morphogenesis" BROAD []
is_a: GO:0048048 ! embryonic eye morphogenesis
relationship: part_of GO:0031076 ! embryonic camera-type eye development
relationship: part_of GO:0048593 ! camera-type eye morphogenesis

[Term]
id: GO:0048597
name: post-embryonic camera-type eye morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the eye are generated and organized during post-embryonic development. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:mtg_transport, ISBN:0815340729]
synonym: "post-embryonic camera-style eye morphogenesis" EXACT []
synonym: "post-embryonic eye morphogenesis" BROAD []
is_a: GO:0048050 ! post-embryonic eye morphogenesis
relationship: part_of GO:0031077 ! post-embryonic camera-type eye development
relationship: part_of GO:0048593 ! camera-type eye morphogenesis

[Term]
id: GO:0048598
name: embryonic morphogenesis
namespace: biological_process
alt_id: GO:0048828
def: "The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jic, GOC:mtg_sensu]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0009790 ! embryonic development

[Term]
id: GO:0048599
name: oocyte development
namespace: biological_process
def: "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators]
is_a: GO:0007281 ! germ cell development
relationship: part_of GO:0009994 ! oocyte differentiation

[Term]
id: GO:0048600
name: oocyte fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into an oocyte." [GOC:go_curators]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0009994 ! oocyte differentiation

[Term]
id: GO:0048601
name: oocyte morphogenesis
namespace: biological_process
def: "The process by which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators]
synonym: "oocyte morphogenesis during differentiation" EXACT []
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0048599 ! oocyte development

[Term]
id: GO:0048602
name: fibroblast growth factor 1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with fibroblast growth factor 1." [GOC:ebc]
synonym: "FGF 1 binding" EXACT []
is_a: GO:0017134 ! fibroblast growth factor binding

[Term]
id: GO:0048603
name: fibroblast growth factor 2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with fibroblast growth factor 2." [GOC:ebc]
synonym: "FGF 2 binding" EXACT []
is_a: GO:0017134 ! fibroblast growth factor binding

[Term]
id: GO:0048604
name: fibroblast growth factor 3 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with fibroblast growth factor 3." [GOC:ebc]
synonym: "FGF 3 binding" EXACT []
is_a: GO:0017134 ! fibroblast growth factor binding

[Term]
id: GO:0048605
name: fibroblast growth factor 4 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with fibroblast growth factor 4." [GOC:ebc]
synonym: "FGF 4 binding" EXACT []
is_a: GO:0017134 ! fibroblast growth factor binding

[Term]
id: GO:0048606
name: fibroblast growth factor 5 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with fibroblast growth factor 5." [GOC:ebc]
synonym: "FGF 5 binding" EXACT []
is_a: GO:0017134 ! fibroblast growth factor binding

[Term]
id: GO:0048607
name: fibroblast growth factor 6 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with fibroblast growth factor 6." [GOC:ebc]
synonym: "FGF 6 binding" EXACT []
is_a: GO:0017134 ! fibroblast growth factor binding

[Term]
id: GO:0048608
name: reproductive structure development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures." [GOC:dph, GOC:isa_complete, GOC:jic]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0048609
name: reproductive process in a multicellular organism
namespace: biological_process
def: "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jic, GOC:tb]
synonym: "organismal reproductive process" EXACT []
is_a: GO:0022414 ! reproductive process
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0032504 ! multicellular organism reproduction

[Term]
id: GO:0048610
name: reproductive cellular process
namespace: biological_process
def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular or single-celled organism." [GOC:dph, GOC:jic]
subset: gosubset_prok
is_a: GO:0009987 ! cellular process
is_a: GO:0022414 ! reproductive process

[Term]
id: GO:0048611
name: embryonic ectodermal gut development
namespace: biological_process
def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure." [GOC:jic, GOC:rc]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007439 ! ectodermal gut development

[Term]
id: GO:0048612
name: post-embryonic ectodermal gut development
namespace: biological_process
def: "The process, occurring during the post-embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure." [GOC:jic, GOC:rc]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007439 ! ectodermal gut development

[Term]
id: GO:0048613
name: embryonic ectodermal gut morphogenesis
namespace: biological_process
def: "The process, occurring during the embryonic phase, by which the anatomical structures of the ectodermal gut are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048558 ! embryonic gut morphogenesis
relationship: part_of GO:0048567 ! ectodermal gut morphogenesis
relationship: part_of GO:0048611 ! embryonic ectodermal gut development

[Term]
id: GO:0048614
name: post-embryonic ectodermal gut morphogenesis
namespace: biological_process
def: "The process, occurring during the post-embryonic phase, by which the anatomical structures of the ectodermal gut are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0048567 ! ectodermal gut morphogenesis
relationship: part_of GO:0048612 ! post-embryonic ectodermal gut development
relationship: part_of GO:0048621 ! post-embryonic gut morphogenesis

[Term]
id: GO:0048615
name: embryonic anterior midgut (ectodermal) morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0007441 ! anterior midgut (ectodermal) morphogenesis
relationship: part_of GO:0048613 ! embryonic ectodermal gut morphogenesis

[Term]
id: GO:0048616
name: post-embryonic anterior midgut (ectodermal) morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the post-embryonic phase. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0007441 ! anterior midgut (ectodermal) morphogenesis
relationship: part_of GO:0048614 ! post-embryonic ectodermal gut morphogenesis

[Term]
id: GO:0048617
name: embryonic foregut morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the foregut are generated and organized, during the embryonic phase. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007440 ! foregut morphogenesis

[Term]
id: GO:0048618
name: post-embryonic foregut morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the foregut are generated and organized, during the post-embryonic phase. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0007440 ! foregut morphogenesis

[Term]
id: GO:0048619
name: embryonic hindgut morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the hindgut are generated and organized, during the embryonic phase. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0007442 ! hindgut morphogenesis

[Term]
id: GO:0048620
name: post-embryonic hindgut morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the hindgut are generated and organized, during the post-embryonic phase. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0007442 ! hindgut morphogenesis

[Term]
id: GO:0048621
name: post-embryonic gut morphogenesis
namespace: biological_process
def: "The process, occurring during the post-embryonic phase, by which the anatomical structures of the gut are generated and organized. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus." [GOC:jic, GOC:rc]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0048547 ! gut morphogenesis

[Term]
id: GO:0048622
name: reproductive sporulation
namespace: biological_process
def: "OBSOLETE. The formation of reproductive spores." [GOC:jic]
comment: This term was made obsolete because it was ambiguously defined and incorrectly placed in the ontology.
is_obsolete: true

[Term]
id: GO:0048623
name: seed germination on parent plant
namespace: biological_process
def: "The process by which a seed germinates before being shed from the parent plant." [GOC:go_curators]
synonym: "non-vegetative vivipary" BROAD []
synonym: "pre-harvest sprouting" EXACT []
synonym: "vivipary" BROAD []
is_a: GO:0009845 ! seed germination

[Term]
id: GO:0048624
name: plantlet formation on parent plant
namespace: biological_process
def: "The process whereby a new plantlet develops from a meristem on the plant body. As part of this process, when the plantlet is large enough to live independently, the physical connection between the new plantlet and the main plant is severed." [GOC:go_curators]
synonym: "vegetative vivipary" BROAD []
synonym: "vivipary" BROAD []
is_a: GO:0019954 ! asexual reproduction
is_a: GO:0032504 ! multicellular organism reproduction
is_a: GO:0048507 ! meristem development

[Term]
id: GO:0048625
name: myoblast cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast cell. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0045445 ! myoblast differentiation

[Term]
id: GO:0048626
name: myoblast cell fate specification
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into a myoblast cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0048625 ! myoblast cell fate commitment

[Term]
id: GO:0048627
name: myoblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0045445 ! myoblast differentiation

[Term]
id: GO:0048628
name: myoblast maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0048627 ! myoblast development

[Term]
id: GO:0048629
name: trichome patterning
namespace: biological_process
def: "The regionalization process of establishing the non-random spatial arrangement of trichomes on the surface and margin of a leaf. Process involves signaling between adjacent epidermal cells that results in differentiation of some epidermal cells into trichomes." [GOC:jic, GOC:mtg_sensu, GOC:sm, GOC:tb, ISBN:0865427429, PMID:10368181]
synonym: "trichome distribution" BROAD []
synonym: "trichome pattern biosynthesis" EXACT []
synonym: "trichome pattern formation" EXACT []
synonym: "trichome pattern specification" RELATED []
synonym: "trichome spacing" EXACT []
is_a: GO:0003002 ! regionalization
is_a: GO:0045168 ! cell-cell signaling involved in cell fate specification
relationship: part_of GO:0010026 ! trichome differentiation

[Term]
id: GO:0048630
name: skeletal muscle tissue growth
namespace: biological_process
def: "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size." [GOC:lm, PMID:15726494, PMID:15907921]
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048631
name: regulation of skeletal muscle tissue growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
relationship: regulates GO:0048630 ! skeletal muscle tissue growth

[Term]
id: GO:0048632
name: negative regulation of skeletal muscle tissue growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921]
synonym: "down regulation of skeletal muscle growth" EXACT []
synonym: "down-regulation of skeletal muscle growth" EXACT []
synonym: "downregulation of skeletal muscle growth" EXACT []
synonym: "inhibition of skeletal muscle growth" NARROW []
is_a: GO:0048631 ! regulation of skeletal muscle tissue growth
is_a: GO:0048640 ! negative regulation of developmental growth
relationship: negatively_regulates GO:0048630 ! skeletal muscle tissue growth
relationship: part_of GO:0048642 ! negative regulation of skeletal muscle tissue development

[Term]
id: GO:0048633
name: positive regulation of skeletal muscle tissue growth
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921]
synonym: "activation of skeletal muscle growth" NARROW []
synonym: "stimulation of skeletal muscle growth" NARROW []
synonym: "up regulation of skeletal muscle growth" EXACT []
synonym: "up-regulation of skeletal muscle growth" EXACT []
synonym: "upregulation of skeletal muscle growth" EXACT []
is_a: GO:0048631 ! regulation of skeletal muscle tissue growth
is_a: GO:0048639 ! positive regulation of developmental growth
relationship: part_of GO:0048643 ! positive regulation of skeletal muscle tissue development
relationship: positively_regulates GO:0048630 ! skeletal muscle tissue growth

[Term]
id: GO:0048634
name: regulation of muscle organ development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle development." [GOC:go_curators]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0007517 ! muscle organ development

[Term]
id: GO:0048635
name: negative regulation of muscle organ development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle development." [GOC:go_curators]
synonym: "down regulation of muscle development" EXACT []
synonym: "down-regulation of muscle development" EXACT []
synonym: "downregulation of muscle development" EXACT []
synonym: "inhibition of muscle development" NARROW []
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0007517 ! muscle organ development

[Term]
id: GO:0048636
name: positive regulation of muscle organ development
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators]
synonym: "activation of muscle development" NARROW []
synonym: "stimulation of muscle development" NARROW []
synonym: "up regulation of muscle development" EXACT []
synonym: "up-regulation of muscle development" EXACT []
synonym: "upregulation of muscle development" EXACT []
is_a: GO:0048634 ! regulation of muscle organ development
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0007517 ! muscle organ development

[Term]
id: GO:0048638
name: regulation of developmental growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators]
is_a: GO:0040008 ! regulation of growth
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0048589 ! developmental growth

[Term]
id: GO:0048639
name: positive regulation of developmental growth
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of developmental growth." [GOC:go_curators]
synonym: "activation of developmental growth" NARROW []
synonym: "stimulation of developmental growth" NARROW []
synonym: "up regulation of developmental growth" EXACT []
synonym: "up-regulation of developmental growth" EXACT []
synonym: "upregulation of developmental growth" EXACT []
is_a: GO:0045927 ! positive regulation of growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0048589 ! developmental growth

[Term]
id: GO:0048640
name: negative regulation of developmental growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators]
synonym: "down regulation of developmental growth" EXACT []
synonym: "down-regulation of developmental growth" EXACT []
synonym: "downregulation of developmental growth" EXACT []
synonym: "inhibition of developmental growth" NARROW []
is_a: GO:0045926 ! negative regulation of growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051093 ! negative regulation of developmental process
relationship: negatively_regulates GO:0048589 ! developmental growth

[Term]
id: GO:0048641
name: regulation of skeletal muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators]
is_a: GO:0016202 ! regulation of striated muscle tissue development
relationship: regulates GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048642
name: negative regulation of skeletal muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators]
synonym: "down regulation of skeletal muscle development" EXACT []
synonym: "down-regulation of skeletal muscle development" EXACT []
synonym: "downregulation of skeletal muscle development" EXACT []
synonym: "inhibition of skeletal muscle development" NARROW []
is_a: GO:0045843 ! negative regulation of striated muscle tissue development
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
relationship: negatively_regulates GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048643
name: positive regulation of skeletal muscle tissue development
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of skeletal muscle tissue development." [GOC:go_curators]
synonym: "activation of skeletal muscle development" NARROW []
synonym: "stimulation of skeletal muscle development" NARROW []
synonym: "up regulation of skeletal muscle development" EXACT []
synonym: "up-regulation of skeletal muscle development" EXACT []
synonym: "upregulation of skeletal muscle development" EXACT []
is_a: GO:0045844 ! positive regulation of striated muscle tissue development
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
relationship: positively_regulates GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048644
name: muscle organ morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of muscle are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0007517 ! muscle organ development

[Term]
id: GO:0048645
name: organ formation
namespace: biological_process
def: "The process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ." [GOC:dph, GOC:jic]
synonym: "initiation of an organ primordium" NARROW []
synonym: "organ primordium initiation" NARROW []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0009887 ! organ morphogenesis

[Term]
id: GO:0048646
name: anatomical structure formation involved in morphogenesis
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jic, GOC:tb]
comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense.
synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0048647
name: polyphenic determination
namespace: biological_process
def: "The process by which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental and/or genetic cues." [GOC:jic]
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0048648
name: caste determination
namespace: biological_process
def: "The process by which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental and/or genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jic]
is_a: GO:0048647 ! polyphenic determination

[Term]
id: GO:0048649
name: caste determination, influence by genetic factors
namespace: biological_process
def: "The process by which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jic]
is_a: GO:0048648 ! caste determination
is_a: GO:0048652 ! polyphenic determination, influence by genetic factors

[Term]
id: GO:0048650
name: caste determination, influence by environmental factors
namespace: biological_process
def: "The process by which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jic]
is_a: GO:0048648 ! caste determination
is_a: GO:0048651 ! polyphenic determination, influence by environmental factors

[Term]
id: GO:0048651
name: polyphenic determination, influence by environmental factors
namespace: biological_process
def: "The process by which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental cues." [GOC:jic]
is_a: GO:0009605 ! response to external stimulus
is_a: GO:0048647 ! polyphenic determination

[Term]
id: GO:0048652
name: polyphenic determination, influence by genetic factors
namespace: biological_process
def: "The process by which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to genetic cues." [GOC:jic]
is_a: GO:0048647 ! polyphenic determination

[Term]
id: GO:0048653
name: anther development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure." [GOC:jic, GOC:sm]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048443 ! stamen development

[Term]
id: GO:0048654
name: anther morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the anther are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:sm]
is_a: GO:0048444 ! floral organ morphogenesis
relationship: part_of GO:0048448 ! stamen morphogenesis
relationship: part_of GO:0048653 ! anther development

[Term]
id: GO:0048655
name: tapetal layer morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the tapetal layer are generated and organized. Morphogenesis pertains to the creation of form. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jic, GOC:sm]
synonym: "differentiation of tapetal layer" NARROW []
synonym: "tapetum morphogenesis" EXACT [GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048654 ! anther morphogenesis
relationship: part_of GO:0048658 ! tapetal layer development

[Term]
id: GO:0048656
name: tapetal layer formation
namespace: biological_process
def: "The process that gives rise to the tapetal layer. This process pertains to the initial formation of a structure from unspecified parts. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jic, GOC:sm]
synonym: "tapetum formation" EXACT [GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048455 ! stamen formation
relationship: part_of GO:0048655 ! tapetal layer morphogenesis

[Term]
id: GO:0048657
name: tapetal cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a tapetal cell. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jic, GOC:sm]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048656 ! tapetal layer formation

[Term]
id: GO:0048658
name: tapetal layer development
namespace: biological_process
def: "The process whose specific outcome is the progression of the tapetal layer over time, from its formation to the mature structure." [GOC:jic, GOC:sm]
synonym: "tapetum development" EXACT [GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048653 ! anther development

[Term]
id: GO:0048659
name: smooth muscle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population." [CL:0000192, GOC:ebc, PMID:1840698]
synonym: "SMC proliferation" EXACT []
is_a: GO:0033002 ! muscle cell proliferation

[Term]
id: GO:0048660
name: regulation of smooth muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc]
synonym: "regulation of SMC proliferation" EXACT []
is_a: GO:0042127 ! regulation of cell proliferation
relationship: regulates GO:0048659 ! smooth muscle cell proliferation

[Term]
id: GO:0048661
name: positive regulation of smooth muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc]
synonym: "activation of smooth muscle cell proliferation" NARROW []
synonym: "positive regulation of SMC proliferation" EXACT []
synonym: "stimulation of smooth muscle cell proliferation" NARROW []
synonym: "up regulation of smooth muscle cell proliferation" EXACT []
synonym: "up-regulation of smooth muscle cell proliferation" EXACT []
synonym: "upregulation of smooth muscle cell proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0048660 ! regulation of smooth muscle cell proliferation
relationship: positively_regulates GO:0048659 ! smooth muscle cell proliferation

[Term]
id: GO:0048662
name: negative regulation of smooth muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc]
synonym: "down regulation of smooth muscle cell proliferation" EXACT []
synonym: "down-regulation of smooth muscle cell proliferation" EXACT []
synonym: "downregulation of smooth muscle cell proliferation" EXACT []
synonym: "inhibition of smooth muscle cell proliferation" NARROW []
synonym: "negative regulation of SMC proliferation" EXACT []
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0048660 ! regulation of smooth muscle cell proliferation
relationship: negatively_regulates GO:0048659 ! smooth muscle cell proliferation

[Term]
id: GO:0048663
name: neuron fate commitment
namespace: biological_process
alt_id: GO:0042055
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph]
synonym: "neuron lineage restriction" EXACT []
synonym: "neuronal lineage restriction" EXACT []
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0030182 ! neuron differentiation

[Term]
id: GO:0048664
name: neuron fate determination
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dph]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0048663 ! neuron fate commitment

[Term]
id: GO:0048665
name: neuron fate specification
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0048663 ! neuron fate commitment

[Term]
id: GO:0048666
name: neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0030182 ! neuron differentiation

[Term]
id: GO:0048667
name: cell morphogenesis involved in neuron differentiation
namespace: biological_process
def: "The process by which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb]
synonym: "neuron morphogenesis involved in differentiation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0048666 ! neuron development

[Term]
id: GO:0048668
name: collateral sprouting
namespace: biological_process
def: "The process by which outgrowths develop from the shafts of existing axons." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0007409 ! axonogenesis

[Term]
id: GO:0048669
name: collateral sprouting in the absence of injury
namespace: biological_process
def: "The process by which outgrowths develop from the axons of intact undamaged neurons." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
is_a: GO:0048668 ! collateral sprouting

[Term]
id: GO:0048670
name: regulation of collateral sprouting
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0050770 ! regulation of axonogenesis
relationship: regulates GO:0048668 ! collateral sprouting

[Term]
id: GO:0048671
name: negative regulation of collateral sprouting
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
synonym: "down regulation of collateral sprouting" EXACT []
synonym: "down-regulation of collateral sprouting" EXACT []
synonym: "downregulation of collateral sprouting" EXACT []
synonym: "inhibition of collateral sprouting" NARROW []
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0048670 ! regulation of collateral sprouting
is_a: GO:0050771 ! negative regulation of axonogenesis
relationship: negatively_regulates GO:0048668 ! collateral sprouting

[Term]
id: GO:0048672
name: positive regulation of collateral sprouting
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
synonym: "activation of collateral sprouting" NARROW []
synonym: "stimulation of collateral sprouting" NARROW []
synonym: "up regulation of collateral sprouting" EXACT []
synonym: "up-regulation of collateral sprouting" EXACT []
synonym: "upregulation of collateral sprouting" EXACT []
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0048670 ! regulation of collateral sprouting
is_a: GO:0050772 ! positive regulation of axonogenesis
relationship: positively_regulates GO:0048668 ! collateral sprouting

[Term]
id: GO:0048673
name: collateral sprouting of intact axon in response to injury
namespace: biological_process
def: "The process by which outgrowths develop from the axons of intact undamaged neurons as a result of injury to an axon. The collateral sprouts typically appear from undamaged axons in a tissue which has had part of its nerve supply removed, and they can often innervate successfully any cells that have lost some or all of their original synaptic input." [GOC:dgh, GOC:dph, GOC:jic]
is_a: GO:0031103 ! axon regeneration
is_a: GO:0048668 ! collateral sprouting

[Term]
id: GO:0048674
name: collateral sprouting of injured axon
namespace: biological_process
def: "The process resulting in reformation of a growth cone by the tip of an injured axon, or in collateral sprouting of the axon. Collateral sprouting is the process by which outgrowths develop from the shafts of existing axons." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
is_a: GO:0048668 ! collateral sprouting
is_a: GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048675
name: axon extension
namespace: biological_process
def: "Long distance growth of a single process." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0007409 ! axonogenesis

[Term]
id: GO:0048676
name: axon extension involved in development
namespace: biological_process
def: "Long distance growth of a single axon process involved in cellular development." [GOC:jic]
is_a: GO:0048675 ! axon extension

[Term]
id: GO:0048677
name: axon extension involved in regeneration
namespace: biological_process
def: "Long distance growth of a single axon process involved in regeneration of the neuron." [GOC:jic]
is_a: GO:0048676 ! axon extension involved in development
is_a: GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048678
name: response to axon injury
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
is_a: GO:0009611 ! response to wounding

[Term]
id: GO:0048679
name: regulation of axon regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0050770 ! regulation of axonogenesis
is_a: GO:0070570 ! regulation of neuron projection regeneration
relationship: regulates GO:0031103 ! axon regeneration

[Term]
id: GO:0048680
name: positive regulation of axon regeneration
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of axon regeneration." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
synonym: "activation of axon regeneration" NARROW []
synonym: "stimulation of axon regeneration" NARROW []
synonym: "up regulation of axon regeneration" EXACT []
synonym: "up-regulation of axon regeneration" EXACT []
synonym: "upregulation of axon regeneration" EXACT []
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0048679 ! regulation of axon regeneration
is_a: GO:0050772 ! positive regulation of axonogenesis
is_a: GO:0070572 ! positive regulation of neuron projection regeneration
relationship: positively_regulates GO:0031103 ! axon regeneration

[Term]
id: GO:0048681
name: negative regulation of axon regeneration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
synonym: "down regulation of axon regeneration" EXACT []
synonym: "down-regulation of axon regeneration" EXACT []
synonym: "downregulation of axon regeneration" EXACT []
synonym: "inhibition of axon regeneration" NARROW []
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0048679 ! regulation of axon regeneration
is_a: GO:0050771 ! negative regulation of axonogenesis
is_a: GO:0070571 ! negative regulation of neuron projection regeneration
relationship: negatively_regulates GO:0031103 ! axon regeneration

[Term]
id: GO:0048682
name: sprouting of injured axon
namespace: biological_process
def: "The process involved in sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0031103 ! axon regeneration

[Term]
id: GO:0048683
name: regulation of collateral sprouting of intact axon in response to injury
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
is_a: GO:0048670 ! regulation of collateral sprouting
is_a: GO:0048679 ! regulation of axon regeneration
relationship: regulates GO:0048673 ! collateral sprouting of intact axon in response to injury

[Term]
id: GO:0048684
name: positive regulation of collateral sprouting of intact axon in response to injury
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
synonym: "activation of collateral sprouting of intact axon in response to injury" NARROW []
synonym: "stimulation of collateral sprouting of intact axon in response to injury" NARROW []
synonym: "up regulation of collateral sprouting of intact axon in response to injury" EXACT []
synonym: "up-regulation of collateral sprouting of intact axon in response to injury" EXACT []
synonym: "upregulation of collateral sprouting of intact axon in response to injury" EXACT []
is_a: GO:0048672 ! positive regulation of collateral sprouting
is_a: GO:0048680 ! positive regulation of axon regeneration
is_a: GO:0048683 ! regulation of collateral sprouting of intact axon in response to injury
relationship: positively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury

[Term]
id: GO:0048685
name: negative regulation of collateral sprouting of intact axon in response to injury
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
synonym: "down regulation of collateral sprouting of intact axon in response to injury" EXACT []
synonym: "down-regulation of collateral sprouting of intact axon in response to injury" EXACT []
synonym: "downregulation of collateral sprouting of intact axon in response to injury" EXACT []
synonym: "inhibition of collateral sprouting of intact axon in response to injury" NARROW []
is_a: GO:0048671 ! negative regulation of collateral sprouting
is_a: GO:0048681 ! negative regulation of axon regeneration
is_a: GO:0048683 ! regulation of collateral sprouting of intact axon in response to injury
relationship: negatively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury

[Term]
id: GO:0048686
name: regulation of sprouting of injured axon
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0048679 ! regulation of axon regeneration
relationship: regulates GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048687
name: positive regulation of sprouting of injured axon
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
synonym: "activation of sprouting of injured axon" NARROW []
synonym: "stimulation of sprouting of injured axon" NARROW []
synonym: "up regulation of sprouting of injured axon" EXACT []
synonym: "up-regulation of sprouting of injured axon" EXACT []
synonym: "upregulation of sprouting of injured axon" EXACT []
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0048680 ! positive regulation of axon regeneration
is_a: GO:0048686 ! regulation of sprouting of injured axon
relationship: positively_regulates GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048688
name: negative regulation of sprouting of injured axon
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
synonym: "down regulation of sprouting of injured axon" EXACT []
synonym: "down-regulation of sprouting of injured axon" EXACT []
synonym: "downregulation of sprouting of injured axon" EXACT []
synonym: "inhibition of sprouting of injured axon" NARROW []
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0048681 ! negative regulation of axon regeneration
is_a: GO:0048686 ! regulation of sprouting of injured axon
relationship: negatively_regulates GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048689
name: formation of growth cone in injured axon
namespace: biological_process
def: "The formation of a growth cone in an injured axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
is_a: GO:0048682 ! sprouting of injured axon

[Term]
id: GO:0048690
name: regulation of axon extension involved in regeneration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
is_a: GO:0030516 ! regulation of axon extension
is_a: GO:0048686 ! regulation of sprouting of injured axon
relationship: regulates GO:0048677 ! axon extension involved in regeneration

[Term]
id: GO:0048691
name: positive regulation of axon extension involved in regeneration
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
synonym: "activation of axon extension involved in regeneration" NARROW []
synonym: "stimulation of axon extension involved in regeneration" NARROW []
synonym: "up regulation of axon extension involved in regeneration" EXACT []
synonym: "up-regulation of axon extension involved in regeneration" EXACT []
synonym: "upregulation of axon extension involved in regeneration" EXACT []
is_a: GO:0045773 ! positive regulation of axon extension
is_a: GO:0048687 ! positive regulation of sprouting of injured axon
is_a: GO:0048690 ! regulation of axon extension involved in regeneration
relationship: positively_regulates GO:0048677 ! axon extension involved in regeneration

[Term]
id: GO:0048692
name: negative regulation of axon extension involved in regeneration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
synonym: "down regulation of axon extension involved in regeneration" EXACT []
synonym: "down-regulation of axon extension involved in regeneration" EXACT []
synonym: "downregulation of axon extension involved in regeneration" EXACT []
synonym: "inhibition of axon extension involved in regeneration" NARROW []
is_a: GO:0030517 ! negative regulation of axon extension
is_a: GO:0048688 ! negative regulation of sprouting of injured axon
is_a: GO:0048690 ! regulation of axon extension involved in regeneration
relationship: negatively_regulates GO:0048677 ! axon extension involved in regeneration

[Term]
id: GO:0048693
name: regulation of collateral sprouting of injured axon
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
is_a: GO:0048670 ! regulation of collateral sprouting
is_a: GO:0048686 ! regulation of sprouting of injured axon
relationship: regulates GO:0048674 ! collateral sprouting of injured axon

[Term]
id: GO:0048694
name: positive regulation of collateral sprouting of injured axon
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
synonym: "activation of collateral sprouting of injured axon" NARROW []
synonym: "stimulation of collateral sprouting of injured axon" NARROW []
synonym: "up regulation of collateral sprouting of injured axon" EXACT []
synonym: "up-regulation of collateral sprouting of injured axon" EXACT []
synonym: "upregulation of collateral sprouting of injured axon" EXACT []
is_a: GO:0048672 ! positive regulation of collateral sprouting
is_a: GO:0048687 ! positive regulation of sprouting of injured axon
is_a: GO:0048693 ! regulation of collateral sprouting of injured axon
relationship: positively_regulates GO:0048674 ! collateral sprouting of injured axon

[Term]
id: GO:0048695
name: negative regulation of collateral sprouting of injured axon
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
synonym: "down regulation of collateral sprouting of injured axon" EXACT []
synonym: "down-regulation of collateral sprouting of injured axon" EXACT []
synonym: "downregulation of collateral sprouting of injured axon" EXACT []
synonym: "inhibition of collateral sprouting of injured axon" NARROW []
is_a: GO:0048671 ! negative regulation of collateral sprouting
is_a: GO:0048688 ! negative regulation of sprouting of injured axon
is_a: GO:0048693 ! regulation of collateral sprouting of injured axon
relationship: negatively_regulates GO:0048674 ! collateral sprouting of injured axon

[Term]
id: GO:0048696
name: regulation of collateral sprouting in the absence of injury
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
is_a: GO:0048670 ! regulation of collateral sprouting
relationship: regulates GO:0048669 ! collateral sprouting in the absence of injury

[Term]
id: GO:0048697
name: positive regulation of collateral sprouting in the absence of injury
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
synonym: "activation of collateral sprouting in the absence of injury" NARROW []
synonym: "stimulation of collateral sprouting in the absence of injury" NARROW []
synonym: "up regulation of collateral sprouting in the absence of injury" EXACT []
synonym: "up-regulation of collateral sprouting in the absence of injury" EXACT []
synonym: "upregulation of collateral sprouting in the absence of injury" EXACT []
is_a: GO:0048672 ! positive regulation of collateral sprouting
is_a: GO:0048696 ! regulation of collateral sprouting in the absence of injury
relationship: positively_regulates GO:0048669 ! collateral sprouting in the absence of injury

[Term]
id: GO:0048698
name: negative regulation of collateral sprouting in the absence of injury
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jic, GOC:lm]
synonym: "down regulation of collateral sprouting in the absence of injury" EXACT []
synonym: "down-regulation of collateral sprouting in the absence of injury" EXACT []
synonym: "downregulation of collateral sprouting in the absence of injury" EXACT []
synonym: "inhibition of collateral sprouting in the absence of injury" NARROW []
is_a: GO:0048671 ! negative regulation of collateral sprouting
is_a: GO:0048696 ! regulation of collateral sprouting in the absence of injury
relationship: negatively_regulates GO:0048669 ! collateral sprouting in the absence of injury

[Term]
id: GO:0048699
name: generation of neurons
namespace: biological_process
def: "The process by which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln]
is_a: GO:0022008 ! neurogenesis

[Term]
id: GO:0048700
name: acquisition of desiccation tolerance
namespace: biological_process
def: "The process by which a seed acquires tolerance to severe drying, before entering into a dry, either dormant or quiescent state." [GOC:jic, GOC:ki]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0022611 ! dormancy process
relationship: part_of GO:0010162 ! seed dormancy

[Term]
id: GO:0048701
name: embryonic cranial skeleton morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of cranial skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form." [GOC:dsf, GOC:jic, PMID:16049113]
synonym: "embryonic cranium morphogenesis" EXACT []
is_a: GO:0048704 ! embryonic skeletal system morphogenesis

[Term]
id: GO:0048702
name: embryonic neurocranium morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of neurocranium are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The neurocranium is the portion of the vertebrate skull surrounding the brain." [GOC:dsf, GOC:jic, PMID:16049113]
synonym: "embryonic braincase morphogenesis" EXACT []
synonym: "embryonic chondrocranium morphogenesis" EXACT [GOC:dph]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048701 ! embryonic cranial skeleton morphogenesis

[Term]
id: GO:0048703
name: embryonic viscerocranium morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of viscerocranium are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The viscerocranium is the part of the skull comprising the facial bones." [GOC:dsf, GOC:jic, PMID:16049113]
synonym: "embryonic pharyngeal skeleton morphogenesis" EXACT []
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048701 ! embryonic cranial skeleton morphogenesis

[Term]
id: GO:0048704
name: embryonic skeletal system morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:dsf, GOC:jic, GOC:tb, PMID:16049113]
synonym: "embryonic skeletal morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0048562 ! embryonic organ morphogenesis
is_a: GO:0048705 ! skeletal system morphogenesis
relationship: part_of GO:0048706 ! embryonic skeletal system development

[Term]
id: GO:0048705
name: skeletal system morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the skeleton are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:dsf, GOC:jic, GOC:tb]
synonym: "skeletal morphogenesis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0001501 ! skeletal system development

[Term]
id: GO:0048706
name: embryonic skeletal system development
namespace: biological_process
def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure." [GOC:dph, GOC:dsf, GOC:jic, GOC:tb, PMID:16049113]
synonym: "embryonic skeletal development" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001501 ! skeletal system development
relationship: part_of GO:0043009 ! chordate embryonic development

[Term]
id: GO:0048707
name: instar larval or pupal morphogenesis
namespace: biological_process
def: "The process, occurring during instar larval or pupal development, by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_sensu, GOC:rc]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0002165 ! instar larval or pupal development

[Term]
id: GO:0048708
name: astrocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:vp, PMID:15139015]
is_a: GO:0010001 ! glial cell differentiation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0048709
name: oligodendrocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system." [GOC:vp, PMID:15139015]
is_a: GO:0010001 ! glial cell differentiation
relationship: part_of GO:0007417 ! central nervous system development

[Term]
id: GO:0048710
name: regulation of astrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015]
is_a: GO:0045685 ! regulation of glial cell differentiation
relationship: regulates GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0048711
name: positive regulation of astrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015]
synonym: "activation of astrocyte differentiation" NARROW []
synonym: "stimulation of astrocyte differentiation" NARROW []
synonym: "up regulation of astrocyte differentiation" EXACT []
synonym: "up-regulation of astrocyte differentiation" EXACT []
synonym: "upregulation of astrocyte differentiation" EXACT []
is_a: GO:0045687 ! positive regulation of glial cell differentiation
is_a: GO:0048710 ! regulation of astrocyte differentiation
relationship: positively_regulates GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0048712
name: negative regulation of astrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015]
synonym: "down regulation of astrocyte differentiation" EXACT []
synonym: "down-regulation of astrocyte differentiation" EXACT []
synonym: "downregulation of astrocyte differentiation" EXACT []
synonym: "inhibition of astrocyte differentiation" NARROW []
is_a: GO:0045686 ! negative regulation of glial cell differentiation
is_a: GO:0048710 ! regulation of astrocyte differentiation
relationship: negatively_regulates GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0048713
name: regulation of oligodendrocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015]
is_a: GO:0045685 ! regulation of glial cell differentiation
relationship: regulates GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0048714
name: positive regulation of oligodendrocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015]
synonym: "activation of oligodendrocyte differentiation" NARROW []
synonym: "stimulation of oligodendrocyte differentiation" NARROW []
synonym: "up regulation of oligodendrocyte differentiation" EXACT []
synonym: "up-regulation of oligodendrocyte differentiation" EXACT []
synonym: "upregulation of oligodendrocyte differentiation" EXACT []
is_a: GO:0045687 ! positive regulation of glial cell differentiation
is_a: GO:0048713 ! regulation of oligodendrocyte differentiation
relationship: positively_regulates GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0048715
name: negative regulation of oligodendrocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015]
synonym: "down regulation of oligodendrocyte differentiation" EXACT []
synonym: "down-regulation of oligodendrocyte differentiation" EXACT []
synonym: "downregulation of oligodendrocyte differentiation" EXACT []
synonym: "inhibition of oligodendrocyte differentiation" NARROW []
is_a: GO:0045686 ! negative regulation of glial cell differentiation
is_a: GO:0048713 ! regulation of oligodendrocyte differentiation
relationship: negatively_regulates GO:0048709 ! oligodendrocyte differentiation

[Term]
id: GO:0048716
name: labrum morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of labrum are generated and organized. Morphogenesis pertains to the creation of form." [GOC:rc]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048726 ! labrum development

[Term]
id: GO:0048717
name: anterior cibarial plate morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of anterior cibarial plate are generated and organized. Morphogenesis pertains to the creation of form." [GOC:rc]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048722 ! anterior cibarial plate development

[Term]
id: GO:0048718
name: fish trap bristle morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of fish trap bristle are generated and organized. Morphogenesis pertains to the creation of form." [GOC:rc]
is_a: GO:0008407 ! bristle morphogenesis
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048725 ! fish trap bristle development

[Term]
id: GO:0048719
name: epistomal sclerite morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of epistomal sclerite are generated and organized. Morphogenesis pertains to the creation of form." [GOC:rc]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048724 ! epistomal sclerite development

[Term]
id: GO:0048720
name: posterior cibarial plate morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of posterior cibarial plate are generated and organized. Morphogenesis pertains to the creation of form." [GOC:rc]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048727 ! posterior cibarial plate development

[Term]
id: GO:0048721
name: clypeus morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of clypeus are generated and organized. Morphogenesis pertains to the creation of form." [GOC:rc]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis
relationship: part_of GO:0048723 ! clypeus development

[Term]
id: GO:0048722
name: anterior cibarial plate development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior cibarial plate over time, from their formation to the mature structure." [GOC:rc]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048723
name: clypeus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the clypeus over time, from its formation to the mature structure. The clypeus is the shield-shaped plate on an insect's head." [GOC:rc]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048724
name: epistomal sclerite development
namespace: biological_process
def: "The process whose specific outcome is the progression of the epistomal sclerite over time, from its formation to the mature structure." [GOC:rc]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048725
name: fish trap bristle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fish trap bristle over time, from its formation to the mature structure." [GOC:rc]
is_a: GO:0022416 ! bristle development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048726
name: labrum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the labrum over time, from its formation to the mature structure." [GOC:rc]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048727
name: posterior cibarial plate development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior cibarial plate over time, from its formation to the mature structure." [GOC:rc]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048728
name: proboscis development
namespace: biological_process
alt_id: GO:0016349
def: "The process whose specific outcome is the progression of the proboscis over time, from its formation to the mature structure." [GOC:rc]
is_a: GO:0048513 ! organ development
relationship: part_of GO:0035213 ! clypeo-labral disc development

[Term]
id: GO:0048729
name: tissue morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:jic]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0009887 ! organ morphogenesis
relationship: part_of GO:0009888 ! tissue development

[Term]
id: GO:0048730
name: epidermis morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the epidermis are generated and organized. Morphogenesis pertains to the creation of form. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:jic, http://cancerweb.ncl.ac.uk/]
synonym: "hypodermis morphogenesis" RELATED [GOC:kmv, GOC:rk]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0008544 ! epidermis development

[Term]
id: GO:0048731
name: system development
namespace: biological_process
def: "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jic]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0048732
name: gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jic]
is_a: GO:0048513 ! organ development

[Term]
id: GO:0048733
name: sebaceous gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure." [GOC:jic]
is_a: GO:0048732 ! gland development

[Term]
id: GO:0048734
name: proboscis morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the proboscis are generated and organized. Morphogenesis pertains to the creation of form. The proboscis is the trunk-like extension of the mouthparts on the adult head." [GOC:jic, GOC:rc]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0048728 ! proboscis development

[Term]
id: GO:0048735
name: haltere morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a haltere are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic, GOC:rc]
is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis
relationship: part_of GO:0007481 ! haltere disc morphogenesis
relationship: part_of GO:0007482 ! haltere development

[Term]
id: GO:0048736
name: appendage development
namespace: biological_process
def: "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism. For example a limb or a branch." [GOC:jic, GOC:rc]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0007275 ! multicellular organismal development

[Term]
id: GO:0048737
name: imaginal disc-derived appendage development
namespace: biological_process
def: "The process whose specific outcome is the progression of an appendage over time, from its formation in the imaginal disc to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism." [GOC:jic, GOC:mtg_sensu, GOC:rc]
is_a: GO:0048736 ! appendage development

[Term]
id: GO:0048738
name: cardiac muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jic, GOC:lm]
synonym: "heart muscle development" EXACT []
is_a: GO:0014706 ! striated muscle tissue development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0048739
name: cardiac muscle fiber development
namespace: biological_process
def: "The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure." [GOC:dph, GOC:jic, GOC:lm]
synonym: "cardiac muscle fibre development" EXACT []
synonym: "heart muscle fiber development" RELATED []
is_a: GO:0048747 ! muscle fiber development
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0048740
name: striated muscle fiber development
namespace: biological_process
def: "OBSOLETE. The process whose specific outcome is the amplification and progression of myoblasts (muscle precursor cells) into terminally differentiated multinucleated muscle fibers." [GOC:dph, GOC:jic, GOC:lm, GOC:mtg_muscle]
comment: This term was made obsolete because it was an unnecessary grouping term. Striated muscle comprises skeletal and cardiac muscle, but GO has opted not to group the muscle fiber development terms.
synonym: "myogenesis" EXACT []
synonym: "striated muscle fibre development" EXACT []
is_obsolete: true

[Term]
id: GO:0048741
name: skeletal muscle fiber development
namespace: biological_process
def: "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:ef, GOC:jic, GOC:lm, GOC:mtg_muscle]
synonym: "skeletal muscle fibre development" EXACT []
synonym: "skeletal myofiber development" EXACT []
synonym: "skeletal myofibre development" EXACT []
is_a: GO:0048747 ! muscle fiber development
relationship: part_of GO:0007519 ! skeletal muscle tissue development

[Term]
id: GO:0048742
name: regulation of skeletal muscle fiber development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jic, GOC:mtg_muscle, GOC:sm]
synonym: "regulation of skeletal muscle fibre development" EXACT []
synonym: "regulation of skeletal myofiber development" EXACT []
synonym: "regulation of skeletal myofibre development" EXACT []
is_a: GO:0048641 ! regulation of skeletal muscle tissue development
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0048743
name: positive regulation of skeletal muscle fiber development
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jic, GOC:lm, GOC:mtg_muscle]
synonym: "activation of skeletal muscle fiber development" NARROW []
synonym: "positive regulation of skeletal muscle fibre development" EXACT []
synonym: "positive regulation of skeletal myofiber development" EXACT []
synonym: "positive regulation of skeletal myofibre development" EXACT []
synonym: "stimulation of skeletal muscle fiber development" NARROW []
synonym: "up regulation of skeletal muscle fiber development" EXACT []
synonym: "up-regulation of skeletal muscle fiber development" EXACT []
synonym: "upregulation of skeletal muscle fiber development" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development
is_a: GO:0048742 ! regulation of skeletal muscle fiber development
relationship: positively_regulates GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0048744
name: negative regulation of skeletal muscle fiber development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jic, GOC:lm, GOC:mtg_muscle]
synonym: "down regulation of skeletal muscle fiber development" EXACT []
synonym: "down-regulation of skeletal muscle fiber development" EXACT []
synonym: "downregulation of skeletal muscle fiber development" EXACT []
synonym: "inhibition of skeletal muscle fiber development" NARROW []
synonym: "negative regulation of skeletal muscle fibre development" EXACT []
synonym: "negative regulation of skeletal myofiber development" EXACT []
synonym: "negative regulation of skeletal myofibre development" EXACT []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0048742 ! regulation of skeletal muscle fiber development
relationship: negatively_regulates GO:0048741 ! skeletal muscle fiber development
relationship: part_of GO:0048642 ! negative regulation of skeletal muscle tissue development

[Term]
id: GO:0048745
name: smooth muscle tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jic, GOC:lm]
is_a: GO:0060537 ! muscle tissue development

[Term]
id: GO:0048746
name: smooth muscle fiber development
namespace: biological_process
def: "OBSOLETE. The process whose specific outcome is the progression of smooth muscle fiber over time, from its formation to the mature structure." [GOC:dph, GOC:jic, GOC:lm, GOC:mtg_muscle]
comment: This term was made obsolete because smooth muscle does not have fibers.
synonym: "smooth muscle fibre development" EXACT []
is_obsolete: true

[Term]
id: GO:0048747
name: muscle fiber development
namespace: biological_process
def: "The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jic, GOC:lm, GOC:mtg_muscle]
synonym: "muscle fibre development" EXACT []
synonym: "myofiber development" EXACT []
synonym: "myofibre development" EXACT []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0007517 ! muscle organ development

[Term]
id: GO:0048749
name: compound eye development
namespace: biological_process
alt_id: GO:0007456
def: "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure." [GOC:jic, GOC:mtg_sensu]
synonym: "insect-type retina development" EXACT [PMID:11735386]
is_a: GO:0001654 ! eye development

[Term]
id: GO:0048750
name: compound eye corneal lens morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the compound eye corneal lens are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0001745 ! compound eye morphogenesis
relationship: part_of GO:0048058 ! compound eye corneal lens development

[Term]
id: GO:0048752
name: semicircular canal morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the semicircular canals are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dgh, GOC:dph, GOC:jic]
synonym: "embryonic semicircular canal morphogenesis" EXACT []
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0060872 ! semicircular canal development

[Term]
id: GO:0048753
name: pigment granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc]
subset: goslim_pir
synonym: "pigment granule organisation" EXACT [GOC:curators]
synonym: "pigment granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0016050 ! vesicle organization
relationship: part_of GO:0033059 ! cellular pigmentation

[Term]
id: GO:0048754
name: branching morphogenesis of a tube
namespace: biological_process
def: "The process by which the anatomical structures of branches in a tube are generated and organized. Morphogenesis pertains to the creation of form. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jic]
synonym: "tubulogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0001763 ! morphogenesis of a branching structure
is_a: GO:0035239 ! tube morphogenesis

[Term]
id: GO:0048755
name: branching morphogenesis of a nerve
namespace: biological_process
def: "The process by which the anatomical structures of branches in a nerve are generated and organized. Morphogenesis pertains to the creation of form. This term refers to an anatomical structure (nerve) not a cell (neuron)." [GOC:dgh, GOC:dph, GOC:jic]
is_a: GO:0001763 ! morphogenesis of a branching structure
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0048756
name: sieve cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a sieve cell. A sieve cell is a type of sieve element that has relatively undifferentiated sieve areas (with narrow pores). The sieve areas are rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants. The sieve element is the cell in the phloem tissue concerned with mainly longitudinal conduction of food materials." [CL:0000294, GOC:jic]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0010088 ! phloem development

[Term]
id: GO:0048757
name: pigment granule maturation
namespace: biological_process
def: "Steps required to form a membrane-bounded organelle into a pigment granule containing pigment. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state." [GOC:dgh, GOC:jic, GOC:mh]
is_a: GO:0021700 ! developmental maturation
is_a: GO:0043482 ! cellular pigment accumulation
relationship: part_of GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0048758
name: companion cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a companion cell. The companion cell is the specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [CL:0000284, GOC:jic]
is_a: GO:0048760 ! parenchymal cell differentiation
relationship: part_of GO:0010088 ! phloem development

[Term]
id: GO:0048759
name: vessel member cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a vessel member cell. A vessel member cell is one of the components of a vessel in the xylem. It is a dead cell with the wall between adjacent members being variously perforated and the walls that persist variously thickened." [GOC:jic, PO:0002003]
synonym: "vessel element cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0010089 ! xylem development

[Term]
id: GO:0048760
name: parenchymal cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a parenchymal cell. Parenchymal cells are the most abundant and versatile cells in plants. They have very few distinguishing characteristics and botanists classify them as any cell type that cannot be assigned to any other structural or functional class. They can redifferentiate and dedifferentiate and are involved in storage, basic metabolism and other processes. The cells are polyhedral, typically with thin, non-lignified cellulose cell walls and nucleate living protoplasm. They vary in size, form, and wall structure." [CL:0000668, GOC:jic, ISBN:069716957X, PO:0005421]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0048761
name: collenchyma cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a collenchyma cell. This is a plant cell in which the primary cell walls are unevenly thickened, with most thickening occurring at the cell corners. Cells are living and able to grow, they are elongated, and lignin and secondary walls absent. Collenchyma cells make up collenchyma tissue which acts as a supporting tissue in growing shoots, leaves and petioles. This tissue is often arranged in cortical ribs, as seen prominently in celery and rhubarb petioles." [CL:0000330, GOC:jic, http://cancerweb.ncl.ac.uk, PO:0000075]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0048762
name: mesenchymal cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph, GOC:jic]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0060485 ! mesenchyme development

[Term]
id: GO:0048763
name: calcium-induced calcium release activity
namespace: molecular_function
def: "Release of calcium ions from an intracellular vesicle on induction by increased calcium concentration." [GOC:jic, GOC:nln, PMID:2990997, PMID:8381210, PMID:8653752]
is_a: GO:0005218 ! intracellular ligand-gated calcium channel activity

[Term]
id: GO:0048764
name: trichoblast maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trichoblast cell to attain its fully functional state." [GOC:jic]
is_a: GO:0048469 ! cell maturation
relationship: part_of GO:0010054 ! trichoblast differentiation

[Term]
id: GO:0048765
name: root hair cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a root hair cell." [GOC:jic]
is_a: GO:0048764 ! trichoblast maturation

[Term]
id: GO:0048766
name: root hair initiation
namespace: biological_process
def: "The process by which a protrusion or bulge is formed at the site of plant root hair outgrowth." [GOC:jic, PMID:12468740]
is_a: GO:0000902 ! cell morphogenesis
relationship: part_of GO:0048765 ! root hair cell differentiation

[Term]
id: GO:0048767
name: root hair elongation
namespace: biological_process
def: "The process by which the root hair grows longer." [GOC:jic, PMID:12468740]
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0048765 ! root hair cell differentiation

[Term]
id: GO:0048768
name: root hair cell tip growth
namespace: biological_process
def: "Localized growth of a plant root hair tip by extension of the cell wall." [GOC:jic, GOC:ki, PMID:12468740]
synonym: "root hair tip growth" EXACT []
is_a: GO:0009932 ! cell tip growth
relationship: part_of GO:0048767 ! root hair elongation

[Term]
id: GO:0048769
name: sarcomerogenesis
namespace: biological_process
def: "The process by which sarcomeres are added in series within a fiber." [GOC:jic, GOC:lm, PMID:15947030]
synonym: "myofibril production" EXACT systematic_synonym []
is_a: GO:0031032 ! actomyosin structure organization
relationship: part_of GO:0030239 ! myofibril assembly

[Term]
id: GO:0048770
name: pigment granule
namespace: cellular_component
def: "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jic, GOC:mh]
is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0048771
name: tissue remodeling
namespace: biological_process
def: "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc]
subset: goslim_pir
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0048772
name: leucophore differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a leucophore cell. Leucophores are pigment cells derived from the neural crest. They contain uric acid or other purine crystals, deposited in stacks called leucosomes. This gives them a white appearance." [GOC:jic, GOC:mh]
synonym: "leucophore cell differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0048773
name: erythrophore differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of an erythrophore cell. Erythrophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives them an orange to red appearance." [GOC:jic, GOC:mh]
synonym: "erythrophore cell differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0048774
name: cyanophore differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a cyanophore cell. Cyanophores are pigment cells derived from the neural crest. They contain a blue pigment of unknown chemical composition. The pigment is stored in fibrous organelles termed cyanosomes." [GOC:jic, GOC:mh]
synonym: "cyanophore cell differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0048775
name: regulation of leucophore differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leucophore differentiation." [GOC:mh]
is_a: GO:0050932 ! regulation of pigment cell differentiation
relationship: regulates GO:0048772 ! leucophore differentiation

[Term]
id: GO:0048776
name: negative regulation of leucophore differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leucophore differentiation." [GOC:mh]
synonym: "down regulation of leucophore differentiation" EXACT []
synonym: "down-regulation of leucophore differentiation" EXACT []
synonym: "downregulation of leucophore differentiation" EXACT []
synonym: "inhibition of leucophore differentiation" NARROW []
is_a: GO:0048775 ! regulation of leucophore differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
relationship: negatively_regulates GO:0048772 ! leucophore differentiation

[Term]
id: GO:0048777
name: positive regulation of leucophore differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leucophore differentiation." [GOC:mh]
synonym: "activation of leucophore differentiation" NARROW []
synonym: "stimulation of leucophore differentiation" NARROW []
synonym: "up regulation of leucophore differentiation" EXACT []
synonym: "up-regulation of leucophore differentiation" EXACT []
synonym: "upregulation of leucophore differentiation" EXACT []
is_a: GO:0048775 ! regulation of leucophore differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
relationship: positively_regulates GO:0048772 ! leucophore differentiation

[Term]
id: GO:0048778
name: regulation of erythrophore differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of erythrophore differentiation." [GOC:mh]
is_a: GO:0050932 ! regulation of pigment cell differentiation
relationship: regulates GO:0048773 ! erythrophore differentiation

[Term]
id: GO:0048779
name: negative regulation of erythrophore differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of erythrophore differentiation." [GOC:mh]
synonym: "down regulation of erythrophore differentiation" EXACT []
synonym: "down-regulation of erythrophore differentiation" EXACT []
synonym: "downregulation of erythrophore differentiation" EXACT []
synonym: "inhibition of erythrophore differentiation" NARROW []
is_a: GO:0048778 ! regulation of erythrophore differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
relationship: negatively_regulates GO:0048773 ! erythrophore differentiation

[Term]
id: GO:0048780
name: positive regulation of erythrophore differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of erythrophore differentiation." [GOC:mh]
synonym: "activation of erythrophore differentiation" NARROW []
synonym: "stimulation of erythrophore differentiation" NARROW []
synonym: "up regulation of erythrophore differentiation" EXACT []
synonym: "up-regulation of erythrophore differentiation" EXACT []
synonym: "upregulation of erythrophore differentiation" EXACT []
is_a: GO:0048778 ! regulation of erythrophore differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
relationship: positively_regulates GO:0048773 ! erythrophore differentiation

[Term]
id: GO:0048781
name: regulation of cyanophore differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyanophore differentiation." [GOC:mh]
is_a: GO:0050932 ! regulation of pigment cell differentiation
relationship: regulates GO:0048774 ! cyanophore differentiation

[Term]
id: GO:0048782
name: negative regulation of cyanophore differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyanophore differentiation." [GOC:mh]
synonym: "down regulation of cyanophore differentiation" EXACT []
synonym: "down-regulation of cyanophore differentiation" EXACT []
synonym: "downregulation of cyanophore differentiation" EXACT []
synonym: "inhibition of cyanophore differentiation" NARROW []
is_a: GO:0048781 ! regulation of cyanophore differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
relationship: negatively_regulates GO:0048774 ! cyanophore differentiation

[Term]
id: GO:0048783
name: positive regulation of cyanophore differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyanophore differentiation." [GOC:mh]
synonym: "activation of cyanophore differentiation" NARROW []
synonym: "stimulation of cyanophore differentiation" NARROW []
synonym: "up regulation of cyanophore differentiation" EXACT []
synonym: "up-regulation of cyanophore differentiation" EXACT []
synonym: "upregulation of cyanophore differentiation" EXACT []
is_a: GO:0048781 ! regulation of cyanophore differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
relationship: positively_regulates GO:0048774 ! cyanophore differentiation

[Term]
id: GO:0048784
name: pigment biosynthetic process during pigment granule maturation
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a pigment, during the process by which a membrane-bounded organelle develops into a pigment granule. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state." [GOC:jic]
is_a: GO:0043477 ! pigment biosynthetic process during pigment accumulation
relationship: part_of GO:0048757 ! pigment granule maturation

[Term]
id: GO:0048785
name: hatching gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hatching gland over time, from its formation to the mature structure. The cells of the hatching gland contain enzymes responsible for solubilization of the egg chorion, facilitating the hatching process." [GOC:bf, GOC:dh, GOC:jic]
is_a: GO:0048732 ! gland development

[Term]
id: GO:0048786
name: presynaptic active zone
namespace: cellular_component
def: "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, synaptic vesicles, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jic, PMID:3152289]
synonym: "pre-synaptic active zone" EXACT []
xref: NIF_Subcellular:sao792027222
is_a: GO:0044456 ! synapse part

[Term]
id: GO:0048787
name: presynaptic active zone membrane
namespace: cellular_component
def: "The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters." [PMID:12812759, PMID:12923177, PMID:3152289]
synonym: "active zone plasma membrane" EXACT []
synonym: "active zone pre-synaptic plasma membrane" EXACT []
synonym: "active zone presynaptic plasma membrane" EXACT []
synonym: "pre-synaptic active zone membrane" EXACT []
is_a: GO:0042734 ! presynaptic membrane
relationship: part_of GO:0048786 ! presynaptic active zone

[Term]
id: GO:0048788
name: presynaptic cytoskeletal matrix assembled at active zones
namespace: cellular_component
def: "The specialized cytoskeletal matrix assembled at the active zones of the presynaptic nerve terminal. The cytoskeletal matrix is a proteinaceous structure involved in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. The cytomatrix protein exclusively assembled at active zones, is thought to form a molecular scaffold that organizes neurotransmitter release sites." [GOC:dh, GOC:dl, GOC:ef, GOC:jic, PMID:10944438]
synonym: "CAZ" NARROW []
synonym: "pre-synaptic cytoskeletal matrix assembled at active zones" RELATED []
synonym: "presynaptic cytomatrix assembled at active zones" EXACT []
is_a: GO:0030863 ! cortical cytoskeleton
is_a: GO:0044456 ! synapse part
relationship: part_of GO:0048786 ! presynaptic active zone

[Term]
id: GO:0048789
name: cytoskeletal matrix organization at active zone
namespace: biological_process
def: "The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane." [GOC:dh, GOC:ef, GOC:jic, PMID:12812759]
is_a: GO:0030865 ! cortical cytoskeleton organization

[Term]
id: GO:0048790
name: maintenance of presynaptic active zone structure
namespace: biological_process
def: "The process by which a neuronal cell maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and dock of vesicles and the release of neurotransmitters." [GOC:curators]
is_a: GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0048791
name: calcium ion-dependent exocytosis of neurotransmitter
namespace: biological_process
def: "The release of a neurotransmitter into the synaptic cleft, where the release step is dependent on the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell." [GOC:curators]
is_a: GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0048792
name: calcium ion-independent exocytosis of neurotransmitter
namespace: biological_process
def: "The release of a neurotransmitter into the synaptic cleft, where the release step is independent of the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell." [GOC:curators]
is_a: GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0048793
name: pronephros development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:bf, PMID:10535314, PMID:15968585]
is_a: GO:0001822 ! kidney development

[Term]
id: GO:0048794
name: swim bladder development
namespace: biological_process
def: "The process whose specific outcome is the progression of the swim bladder over time, from its formation to the mature structure. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh]
synonym: "gas bladder development" EXACT []
is_a: GO:0048513 ! organ development

[Term]
id: GO:0048795
name: swim bladder morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the swim bladder is generated and organized. Morphogenesis pertains to the creation of form. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh]
synonym: "gas bladder morphogenesis" EXACT []
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0048794 ! swim bladder development

[Term]
id: GO:0048796
name: swim bladder maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a swim bladder to attain its fully functional state. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:devbiol]
synonym: "gas bladder maturation" EXACT []
is_a: GO:0048799 ! organ maturation
relationship: part_of GO:0048794 ! swim bladder development

[Term]
id: GO:0048797
name: swim bladder formation
namespace: biological_process
def: "The process that gives rise to the swim bladder. This process pertains to the initial formation of a structure from unspecified parts. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh]
synonym: "gas bladder biosynthesis" EXACT []
synonym: "gas bladder formation" EXACT []
is_a: GO:0048645 ! organ formation
relationship: part_of GO:0048795 ! swim bladder morphogenesis

[Term]
id: GO:0048798
name: swim bladder inflation
namespace: biological_process
def: "The expansion of the swim bladder by trapped gases. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh]
synonym: "gas bladder inflation" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048796 ! swim bladder maturation

[Term]
id: GO:0048799
name: organ maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for an organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions." [GOC:curators]
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0048513 ! organ development

[Term]
id: GO:0048800
name: antennal morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of antenna are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis
relationship: part_of GO:0007469 ! antennal development

[Term]
id: GO:0048801
name: antennal joint morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the antennal joint are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048098 ! antennal joint development
relationship: part_of GO:0048800 ! antennal morphogenesis

[Term]
id: GO:0048802
name: notum morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of dorsal part of the body are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jic]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007472 ! wing disc morphogenesis
relationship: part_of GO:0007477 ! notum development

[Term]
id: GO:0048803
name: imaginal disc-derived male genitalia morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc. Morphogenesis pertains to the creation of form." [GOC:ai, GOC:sensu]
synonym: "male genital morphogenesis" BROAD []
is_a: GO:0048805 ! imaginal disc-derived genitalia morphogenesis
is_a: GO:0048808 ! male genitalia morphogenesis
relationship: part_of GO:0007485 ! imaginal disc-derived male genitalia development

[Term]
id: GO:0048804
name: imaginal disc-derived female genitalia morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of female genitalia are generated and organized from the genital disc. Morphogenesis pertains to the creation of form." [GOC:ai, GOC:sensu]
synonym: "female genital morphogenesis" BROAD []
is_a: GO:0048805 ! imaginal disc-derived genitalia morphogenesis
is_a: GO:0048807 ! female genitalia morphogenesis
relationship: part_of GO:0007486 ! imaginal disc-derived female genitalia development

[Term]
id: GO:0048805
name: imaginal disc-derived genitalia morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of genitalia are generated and organized from the genital imaginal disc. Morphogenesis pertains to the creation of form." [GOC:ai, GOC:sensu]
synonym: "genital morphogenesis" BROAD []
is_a: GO:0035112 ! genitalia morphogenesis
relationship: part_of GO:0007483 ! genital disc morphogenesis
relationship: part_of GO:0007484 ! imaginal disc-derived genitalia development

[Term]
id: GO:0048806
name: genitalia development
namespace: biological_process
def: "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jic]
synonym: "genital development" EXACT []
is_a: GO:0048513 ! organ development
relationship: part_of GO:0007548 ! sex differentiation

[Term]
id: GO:0048807
name: female genitalia morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of female genitalia are generated and organized. Morphogenesis pertains to the creation of form." [GOC:mah]
synonym: "female genital morphogenesis" RELATED []
is_a: GO:0035112 ! genitalia morphogenesis
relationship: part_of GO:0030540 ! female genitalia development

[Term]
id: GO:0048808
name: male genitalia morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of male genitalia are generated and organized. Morphogenesis pertains to the creation of form." [GOC:ems, ISBN:0140512888]
synonym: "male genital morphogenesis" RELATED []
is_a: GO:0035112 ! genitalia morphogenesis
relationship: part_of GO:0030539 ! male genitalia development

[Term]
id: GO:0048809
name: analia morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of analia are generated and organized. Morphogenesis pertains to the creation of form. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia morphogenesis in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007483 ! genital disc morphogenesis
relationship: part_of GO:0007487 ! analia development

[Term]
id: GO:0048810
name: female analia morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the analia of the female are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. Morphogenesis pertains to the creation of form. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318]
is_a: GO:0048809 ! analia morphogenesis
relationship: part_of GO:0045497 ! female analia development

[Term]
id: GO:0048811
name: male analia morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the analia of the male are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. Morphogenesis pertains to the creation of form." [GOC:mtg_sensu, PMID:11494318]
is_a: GO:0048809 ! analia morphogenesis
relationship: part_of GO:0045496 ! male analia development

[Term]
id: GO:0048812
name: neuron projection morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a neuron projection are generated and organized. Morphogenesis pertains to the creation of form. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]
synonym: "neurite biosynthesis" NARROW []
synonym: "neurite formation" NARROW []
synonym: "neurite growth" NARROW []
synonym: "neurite morphogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0048858 ! cell projection morphogenesis
relationship: part_of GO:0031175 ! neuron projection development

[Term]
id: GO:0048813
name: dendrite morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of dendrite are generated and organized. Morphogenesis pertains to the creation of form. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0048812 ! neuron projection morphogenesis
relationship: part_of GO:0016358 ! dendrite development
relationship: part_of GO:0048667 ! cell morphogenesis involved in neuron differentiation

[Term]
id: GO:0048814
name: regulation of dendrite morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:0050773 ! regulation of dendrite development
relationship: regulates GO:0048813 ! dendrite morphogenesis

[Term]
id: GO:0048815
name: hermaphrodite genitalia morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of hermaphrodite genitalia are generated and organized. Morphogenesis pertains to the creation of form." [GOC:ems, ISBN:0140512888]
is_a: GO:0035112 ! genitalia morphogenesis
relationship: part_of GO:0040035 ! hermaphrodite genitalia development

[Term]
id: GO:0048816
name: ocellus morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the ocellus are generated and organized. Morphogenesis pertains to the creation of form. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis
relationship: part_of GO:0008056 ! ocellus development

[Term]
id: GO:0048817
name: negative regulation of hair follicle maturation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hair follicle maturation." [GOC:devbiol]
synonym: "down regulation of hair follicle maturation" EXACT []
synonym: "down-regulation of hair follicle maturation" EXACT []
synonym: "downregulation of hair follicle maturation" EXACT []
synonym: "inhibition of hair follicle maturation" NARROW []
is_a: GO:0048819 ! regulation of hair follicle maturation
is_a: GO:0051799 ! negative regulation of hair follicle development
relationship: negatively_regulates GO:0048820 ! hair follicle maturation

[Term]
id: GO:0048818
name: positive regulation of hair follicle maturation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hair follicle maturation." [GOC:devbiol]
synonym: "activation of hair follicle maturation" NARROW []
synonym: "stimulation of hair follicle maturation" NARROW []
synonym: "up regulation of hair follicle maturation" EXACT []
synonym: "up-regulation of hair follicle maturation" EXACT []
synonym: "upregulation of hair follicle maturation" EXACT []
is_a: GO:0048819 ! regulation of hair follicle maturation
is_a: GO:0051798 ! positive regulation of hair follicle development
relationship: positively_regulates GO:0048820 ! hair follicle maturation

[Term]
id: GO:0048819
name: regulation of hair follicle maturation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hair follicle maturation." [GOC:devbiol]
is_a: GO:0051797 ! regulation of hair follicle development
relationship: regulates GO:0048820 ! hair follicle maturation

[Term]
id: GO:0048820
name: hair follicle maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state." [GOC:devbiol]
is_a: GO:0021700 ! developmental maturation
is_a: GO:0022405 ! hair cycle process
relationship: part_of GO:0001942 ! hair follicle development

[Term]
id: GO:0048821
name: erythrocyte development
namespace: biological_process
def: "The process aimed at the progression of an erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol]
synonym: "RBC development" EXACT [CL:0000232]
synonym: "red blood cell development" EXACT [CL:0000232]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0030218 ! erythrocyte differentiation

[Term]
id: GO:0048822
name: enucleate erythrocyte development
namespace: biological_process
def: "The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol]
synonym: "enucleate RBC development" EXACT [CL:0000232]
synonym: "enucleate red blood cell development" EXACT [CL:0000232]
is_a: GO:0048821 ! erythrocyte development
relationship: part_of GO:0043353 ! enucleate erythrocyte differentiation

[Term]
id: GO:0048823
name: nucleate erythrocyte development
namespace: biological_process
def: "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol]
synonym: "nucleate RBC development" EXACT [CL:0000232]
synonym: "nucleate red blood cell development" EXACT [CL:0000232]
is_a: GO:0048821 ! erythrocyte development
relationship: part_of GO:0043363 ! nucleate erythrocyte differentiation

[Term]
id: GO:0048824
name: pigment cell precursor differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a pigment cell precursor." [GOC:dgh, PMID:16499899]
synonym: "chromatophore precursor differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0048825
name: cotyledon development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cotyledon over time, from its formation to the mature structure. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling." [GOC:devbiol, GOC:tb, http://cancerweb.ncl.ac.uk]
is_a: GO:0009793 ! embryonic development ending in seed dormancy
is_a: GO:0048827 ! phyllome development

[Term]
id: GO:0048826
name: cotyledon morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the cotyledon are generated and organized. Morphogenesis pertains to the creation of form. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling." [GOC:devbiol, GOC:tb, http://cancerweb.ncl.ac.uk]
is_a: GO:0009886 ! post-embryonic morphogenesis
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0048825 ! cotyledon development

[Term]
id: GO:0048827
name: phyllome development
namespace: biological_process
def: "The process whose specific outcome is the progression of a phyllome over time, from its formation to the mature structure. A phyllome is a collective term for all the different types of leaves appearing on plants." [GOC:devbiol, GOC:tb, PO:0006001]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048367 ! shoot development

[Term]
id: GO:0048829
name: root cap development
namespace: biological_process
def: "The process whose specific outcome is the progression of the root cap over time, from its formation to the mature structure. The root cap protects the root meristem from friction as the root grows through the soil. The cap is made up of a group of parenchyma cells which secrete a glycoprotein mucilage as a lubricant." [GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048364 ! root development

[Term]
id: GO:0048830
name: adventitious root development
namespace: biological_process
def: "The process whose specific outcome is the progression of adventitious root over time, from its formation to the mature structure. Adventitious roots are post-embryonic roots that develop from the plant shoot." [GOC:tb]
is_a: GO:0048364 ! root development

[Term]
id: GO:0048831
name: regulation of shoot development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of shoot development." [GOC:tb, PMID:16361392]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0048367 ! shoot development

[Term]
id: GO:0048832
name: specification of organ number
namespace: biological_process
def: "The regionalization process that modulates the quantity of a particular type of organ." [GOC:dph, GOC:isa_complete, GOC:tb]
is_a: GO:0003002 ! regionalization
is_a: GO:0050793 ! regulation of developmental process

[Term]
id: GO:0048833
name: specification of floral organ number
namespace: biological_process
def: "Any process that modulates the number of floral organs formed in a floral whorl." [GOC:tb]
is_a: GO:0048832 ! specification of organ number
relationship: part_of GO:0009908 ! flower development

[Term]
id: GO:0048834
name: specification of petal number
namespace: biological_process
def: "Any process that modulates the number of petals formed in a flower." [GOC:tb]
is_a: GO:0048833 ! specification of floral organ number
relationship: part_of GO:0048465 ! corolla development

[Term]
id: GO:0048835
name: specification of decreased petal number
namespace: biological_process
def: "Any process that reduces the number of petals produced in a developing flower." [GOC:tb]
is_a: GO:0048834 ! specification of petal number

[Term]
id: GO:0048836
name: specification of increased petal number
namespace: biological_process
def: "Any process that increases the number of petals produced in a developing flower." [GOC:tb]
is_a: GO:0048834 ! specification of petal number

[Term]
id: GO:0048837
name: sorus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the sorus over time, from its formation to the mature structure. A sorus is a mass of spores." [DDB_REF:2530 "DictyBase paper repository", GOC:devbiol, GOC:mtg_sensu]
synonym: "sorus biosynthesis" EXACT []
synonym: "sorus formation" EXACT []
synonym: "spore head biosynthesis" EXACT []
synonym: "spore head formation" EXACT []
synonym: "spore head morphogenesis" EXACT []
is_a: GO:0048608 ! reproductive structure development
relationship: part_of GO:0031154 ! culmination during sorocarp development

[Term]
id: GO:0048838
name: release of seed from dormancy
namespace: biological_process
def: "The process by which the dormant state is broken in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated upon release." [GOC:dph, GOC:jic, GOC:tb]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0022611 ! dormancy process
relationship: part_of GO:0010162 ! seed dormancy

[Term]
id: GO:0048839
name: inner ear development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure." [GOC:sr]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043583 ! ear development

[Term]
id: GO:0048840
name: otolith development
namespace: biological_process
def: "The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure." [GOC:sr]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048839 ! inner ear development

[Term]
id: GO:0048841
name: regulation of axon extension involved in axon guidance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]
is_a: GO:0030516 ! regulation of axon extension
is_a: GO:0051270 ! regulation of cellular component movement
relationship: regulates GO:0048846 ! axon extension involved in axon guidance

[Term]
id: GO:0048842
name: positive regulation of axon extension involved in axon guidance
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]
synonym: "activation of axon extension involved in axon guidance" NARROW []
synonym: "stimulation of axon extension involved in axon guidance" NARROW []
synonym: "up regulation of axon extension involved in axon guidance" EXACT []
synonym: "up-regulation of axon extension involved in axon guidance" EXACT []
synonym: "upregulation of axon extension involved in axon guidance" EXACT []
is_a: GO:0045773 ! positive regulation of axon extension
is_a: GO:0048841 ! regulation of axon extension involved in axon guidance
relationship: positively_regulates GO:0048846 ! axon extension involved in axon guidance

[Term]
id: GO:0048843
name: negative regulation of axon extension involved in axon guidance
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]
synonym: "down regulation of axon extension involved in axon guidance" EXACT []
synonym: "down-regulation of axon extension involved in axon guidance" EXACT []
synonym: "downregulation of axon extension involved in axon guidance" EXACT []
synonym: "inhibition of axon extension involved in axon guidance" NARROW []
is_a: GO:0030517 ! negative regulation of axon extension
is_a: GO:0048841 ! regulation of axon extension involved in axon guidance
relationship: negatively_regulates GO:0048846 ! axon extension involved in axon guidance

[Term]
id: GO:0048844
name: artery morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of arterial blood vessels are generated and organized. Morphogenesis pertains to the creation of form. Arteries are blood vessels that transport blood from the heart to the body and its organs." [GOC:dsf, PMID:16740480]
synonym: "arterial morphogenesis" EXACT []
synonym: "arteriogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0048514 ! blood vessel morphogenesis
relationship: part_of GO:0060840 ! artery development

[Term]
id: GO:0048845
name: venous blood vessel morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of venous blood vessels are generated and organized. Morphogenesis pertains to the creation of form. Veins are blood vessels that transport blood from the body and its organs to the heart." [GOC:dsf, PMID:16740480]
synonym: "vein morphogenesis" BROAD []
synonym: "venous morphogenesis" EXACT []
is_a: GO:0048514 ! blood vessel morphogenesis
relationship: part_of GO:0060841 ! venous blood vessel development

[Term]
id: GO:0048846
name: axon extension involved in axon guidance
namespace: biological_process
def: "The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues." [GOC:ef, GOC:jic]
is_a: GO:0048675 ! axon extension
relationship: part_of GO:0007411 ! axon guidance

[Term]
id: GO:0048847
name: adenohypophysis formation
namespace: biological_process
def: "The process that gives rise to adenohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jic]
synonym: "adenophysis biosynthesis" EXACT []
synonym: "adenophysis formation" EXACT []
synonym: "anterior pituitary biosynthesis" EXACT []
synonym: "anterior pituitary formation" EXACT []
synonym: "anterior pituitary gland biosynthesis" EXACT []
synonym: "anterior pituitary gland formation" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048855 ! adenohypophysis morphogenesis

[Term]
id: GO:0048848
name: neurohypophysis morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of neurohypophysis are generated and organized. Morphogenesis pertains to the creation of form. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic]
synonym: "neurophysis morphogenesis" EXACT []
synonym: "posterior pituitary gland morphogenesis" EXACT []
synonym: "posterior pituitary morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021985 ! neurohypophysis development
relationship: part_of GO:0048850 ! hypophysis morphogenesis

[Term]
id: GO:0048849
name: neurohypophysis formation
namespace: biological_process
def: "The process that gives rise to neurohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic]
synonym: "neurophysis biosynthesis" EXACT []
synonym: "neurophysis formation" EXACT []
synonym: "posterior pituitary biosynthesis" EXACT []
synonym: "posterior pituitary formation" EXACT []
synonym: "posterior pituitary gland biosynthesis" EXACT []
synonym: "posterior pituitary gland formation" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048848 ! neurohypophysis morphogenesis

[Term]
id: GO:0048850
name: hypophysis morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the hypophysis are generated and organized. Morphogenesis pertains to the creation of form. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic]
synonym: "pituitary gland morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021983 ! pituitary gland development
relationship: part_of GO:0022612 ! gland morphogenesis
relationship: part_of GO:0048852 ! diencephalon morphogenesis

[Term]
id: GO:0048851
name: hypophysis formation
namespace: biological_process
def: "The process by which the anatomical structures of the hypophysis are generated and organized. Morphogenesis pertains to the creation of form. The hypophysis is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic]
synonym: "hypophysis biosynthesis" EXACT []
synonym: "pituitary gland biosynthesis" EXACT []
synonym: "pituitary gland formation" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048850 ! hypophysis morphogenesis

[Term]
id: GO:0048852
name: diencephalon morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of diencephalon are generated and organized. Morphogenesis pertains to the creation of form. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jic, ISBN:0838580343]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021536 ! diencephalon development
relationship: part_of GO:0048853 ! forebrain morphogenesis

[Term]
id: GO:0048853
name: forebrain morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the forebrain are generated and organized. Morphogenesis pertains to the creation of form. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jic]
synonym: "prosencephalon morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0030900 ! forebrain development
relationship: part_of GO:0048854 ! brain morphogenesis

[Term]
id: GO:0048854
name: brain morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of brain are generated and organized. Morphogenesis pertains to the creation of form. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jic]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0007420 ! brain development

[Term]
id: GO:0048855
name: adenohypophysis morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the adenohypophysis are generated and organized. Morphogenesis pertains to the creation of form. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jic]
synonym: "adenophysis morphogenesis" EXACT []
synonym: "anterior pituitary gland morphogenesis" EXACT []
synonym: "anterior pituitary morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0021984 ! adenohypophysis development
relationship: part_of GO:0048850 ! hypophysis morphogenesis

[Term]
id: GO:0048856
name: anatomical structure development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
synonym: "development of an anatomical structure" EXACT []
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0048857
name: neural nucleus development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0048858
name: cell projection morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a cell projection are generated and organized. Morphogenesis pertains to the creation of form." [GO_REF:0000021, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0030030 ! cell projection organization
is_a: GO:0032990 ! cell part morphogenesis
relationship: part_of GO:0000902 ! cell morphogenesis

[Term]
id: GO:0048859
name: formation of anatomical boundary
namespace: biological_process
def: "The process by which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021, GOC:mtg_15jun06]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0048860
name: glioblast cell division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a glioblast into daughter cells." [GOC:devbiol]
is_a: GO:0051301 ! cell division

[Term]
id: GO:0048861
name: leukemia inhibitory factor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands." [GOC:devbiol]
synonym: "leukemia inhibitory factor signalling pathway" EXACT []
is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway

[Term]
id: GO:0048863
name: stem cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete]
xref: Wikipedia:Stem_cell_differentiation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0048864
name: stem cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate." [CL:0000034, GOC:isa_complete]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0048863 ! stem cell differentiation

[Term]
id: GO:0048865
name: stem cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a stem cell." [CL:0000034, GOC:isa_complete]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0048863 ! stem cell differentiation

[Term]
id: GO:0048866
name: stem cell fate specification
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [CL:0000034, GOC:isa_complete]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0048865 ! stem cell fate commitment

[Term]
id: GO:0048867
name: stem cell fate determination
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into a stem cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000034, GOC:isa_complete]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0048865 ! stem cell fate commitment

[Term]
id: GO:0048868
name: pollen tube development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pollen tube over time, from its initial formation to a mature structure." [GOC:isa_complete]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0009856 ! pollination

[Term]
id: GO:0048869
name: cellular developmental process
namespace: biological_process
def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete]
subset: gosubset_prok
is_a: GO:0009987 ! cellular process
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0048870
name: cell motility
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]
subset: gosubset_prok
synonym: "cell locomotion" EXACT []
synonym: "cell movement" EXACT []
synonym: "movement of a cell" EXACT []
is_a: GO:0006928 ! cellular component movement
is_a: GO:0040011 ! locomotion
relationship: part_of GO:0051674 ! localization of cell

[Term]
id: GO:0048871
name: multicellular organismal homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium at the level of the multicellular organism." [GOC:isa_complete]
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0048872
name: homeostasis of number of cells
namespace: biological_process
def: "Any biological process involved in the maintenance of the equilibrium of cell number within a population of cells." [GOC:isa_complete]
synonym: "cell population homeostasis" EXACT []
synonym: "homeostasis of cell number" EXACT [GOC:dph]
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0048873
name: homeostasis of number of cells within a tissue
namespace: biological_process
def: "Any biological process involved in the maintenance of the equilibrium of cell number within a population of cells in a tissue." [GOC:isa_complete]
is_a: GO:0001894 ! tissue homeostasis
is_a: GO:0048872 ! homeostasis of number of cells

[Term]
id: GO:0048874
name: homeostasis of number of cells in a free-living population
namespace: biological_process
def: "The biological process involved in maintaining the equilibrium of cell number within a population of free-living cells such as the bacteria in the gut." [GOC:isa_complete]
subset: gosubset_prok
is_a: GO:0048872 ! homeostasis of number of cells
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0048875
name: chemical homeostasis within a tissue
namespace: biological_process
def: "Any process involved in the maintenance of the internal equilibrium of the amount of a chemical at the level of the tissue." [GOC:isa_complete]
is_a: GO:0001894 ! tissue homeostasis
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0048876
name: chemical homeostasis within retina
namespace: biological_process
def: "Any process involved in the maintenance of the internal equilibrium of the amount of a chemical at the level of the retina." [GOC:isa_complete]
is_a: GO:0001895 ! retina homeostasis
is_a: GO:0048875 ! chemical homeostasis within a tissue

[Term]
id: GO:0048877
name: homeostasis of number of retina cells
namespace: biological_process
def: "Any biological process involved in the maintenance of the equilibrium of cell number within a population of cells in the retina." [GOC:dph, GOC:isa_complete, GOC:tb]
is_a: GO:0001895 ! retina homeostasis
is_a: GO:0048873 ! homeostasis of number of cells within a tissue

[Term]
id: GO:0048878
name: chemical homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal equilibrium of a chemical." [GOC:isa_complete]
subset: gosubset_prok
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0048880
name: sensory system development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure." [GOC:dgh]
is_a: GO:0048731 ! system development

[Term]
id: GO:0048881
name: mechanosensory lateral line system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the mechanosensory lateral line system over time, from its formation to the mature structure. The mechanosensory lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509]
synonym: "LL system development" EXACT [ISBN:0125296509]
is_a: GO:0048925 ! lateral line system development

[Term]
id: GO:0048882
name: lateral line development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral line over time, from its formation to the mature structure. The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear." [ISBN:0125296509]
synonym: "LL development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048925 ! lateral line system development

[Term]
id: GO:0048883
name: neuromast primordium migration
namespace: biological_process
def: "The migration of a cluster of a relatively undifferentiated cell originating at specific cephalic placodes and depositing proneuromasts along a developing lateral line, from which the neuromasts will develop." [PMID:15018940, PMID:15832385]
synonym: "lateral line primordium migration" EXACT []
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0048882 ! lateral line development

[Term]
id: GO:0048884
name: neuromast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the neuromast over time, from its formation to the mature structure. The neuromast is the sensory organ of the lateral line and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromasts are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509]
is_a: GO:0007423 ! sensory organ development
relationship: part_of GO:0048882 ! lateral line development

[Term]
id: GO:0048885
name: neuromast deposition
namespace: biological_process
def: "The process by which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in a developing lateral line." [PMID:15018940]
is_a: GO:0030336 ! negative regulation of cell migration
relationship: part_of GO:0048884 ! neuromast development

[Term]
id: GO:0048886
name: neuromast hair cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509]
is_a: GO:0042490 ! mechanoreceptor differentiation
relationship: part_of GO:0048884 ! neuromast development

[Term]
id: GO:0048887
name: cupula development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048884 ! neuromast development

[Term]
id: GO:0048888
name: neuromast mantle cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048884 ! neuromast development

[Term]
id: GO:0048889
name: neuromast support cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0125296509]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048884 ! neuromast development

[Term]
id: GO:0048890
name: lateral line ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral line ganglion over time, from its formation to the mature structure. The lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear and behind the ear." [ISBN:0125296509, ISBN:0387968377]
synonym: "gLL ganglion development" EXACT []
is_a: GO:0048857 ! neural nucleus development
relationship: part_of GO:0007422 ! peripheral nervous system development
relationship: part_of GO:0048925 ! lateral line system development

[Term]
id: GO:0048891
name: lateral line ganglion neuron differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a lateral line ganglion neuron." [PMID:15018940]
synonym: "gLL neuron differentiation" EXACT []
is_a: GO:0048934 ! peripheral nervous system neuron differentiation
relationship: part_of GO:0048890 ! lateral line ganglion development

[Term]
id: GO:0048892
name: lateral line nerve development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [ISBN:0125296509]
synonym: "nLL development" EXACT []
is_a: GO:0021545 ! cranial nerve development
relationship: part_of GO:0048925 ! lateral line system development

[Term]
id: GO:0048893
name: afferent axon development in a lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an afferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in any lateral line nerve." [PMID:15832385]
is_a: GO:0048936 ! peripheral nervous system neuron axonogenesis
relationship: part_of GO:0048892 ! lateral line nerve development

[Term]
id: GO:0048894
name: efferent axon development in a lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an efferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in any lateral line nerve." [PMID:15832385]
is_a: GO:0021955 ! central nervous system neuron axonogenesis
relationship: part_of GO:0048892 ! lateral line nerve development

[Term]
id: GO:0048895
name: lateral line nerve glial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a glial cell in a lateral line nerve." [PMID:12062041]
is_a: GO:0010001 ! glial cell differentiation
relationship: part_of GO:0048892 ! lateral line nerve development

[Term]
id: GO:0048896
name: glial cell migration in a lateral line nerve
namespace: biological_process
def: "The movement of a glial cell along the axons in a lateral line nerve." [PMID:12062041]
is_a: GO:0008347 ! glial cell migration
relationship: part_of GO:0048892 ! lateral line nerve development

[Term]
id: GO:0048897
name: myelination of lateral line nerve axons
namespace: biological_process
def: "The formation of compact myelin sheaths around the axons of a lateral line nerve." [PMID:12112375]
is_a: GO:0042552 ! myelination
relationship: part_of GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation

[Term]
id: GO:0048898
name: anterior lateral line system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior lateral line system over time, from its formation to the mature structure. The anterior lateral line system develops from cranial ectodermal placodes, situated between the eye and the ear, that give rise to both the neuromasts and the anterior lateral line sensory nerves that innervate the neuromasts. The anterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians and are innervated by several lateral line nerves, which project to the hindbrain. The anterior lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940]
synonym: "ALL system development" RELATED []
is_a: GO:0048925 ! lateral line system development
relationship: part_of GO:0048881 ! mechanosensory lateral line system development

[Term]
id: GO:0048899
name: anterior lateral line development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior lateral line over time, from its formation to the mature structure. The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509]
synonym: "anterior LL development" EXACT []
is_a: GO:0048882 ! lateral line development
relationship: part_of GO:0048898 ! anterior lateral line system development

[Term]
id: GO:0048900
name: anterior lateral line neuromast primordium migration
namespace: biological_process
def: "The migration of a cluster of a relatively undifferentiated cell along the developing anterior lateral line, originating from cranial ectodermal placodes situated between the eye and the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop." [GOC:dgh, PMID:15832385]
synonym: "ALL neuromast primordium migration" EXACT []
is_a: GO:0048883 ! neuromast primordium migration
relationship: part_of GO:0048899 ! anterior lateral line development

[Term]
id: GO:0048901
name: anterior lateral line neuromast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509]
is_a: GO:0048884 ! neuromast development
relationship: part_of GO:0048899 ! anterior lateral line development

[Term]
id: GO:0048902
name: anterior lateral line neuromast deposition
namespace: biological_process
def: "The process by which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing anterior lateral line." [PMID:15832385]
is_a: GO:0048885 ! neuromast deposition
relationship: part_of GO:0048901 ! anterior lateral line neuromast development

[Term]
id: GO:0048903
name: anterior lateral line neuromast hair cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Neuromast hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509, ISBN:0387968377]
is_a: GO:0048886 ! neuromast hair cell differentiation
relationship: part_of GO:0048901 ! anterior lateral line neuromast development

[Term]
id: GO:0048904
name: anterior lateral line neuromast cupula development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509]
is_a: GO:0048887 ! cupula development
relationship: part_of GO:0048901 ! anterior lateral line neuromast development

[Term]
id: GO:0048905
name: anterior lateral line neuromast mantle cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509]
is_a: GO:0048888 ! neuromast mantle cell differentiation
relationship: part_of GO:0048901 ! anterior lateral line neuromast development

[Term]
id: GO:0048906
name: anterior lateral line neuromast support cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377]
is_a: GO:0048889 ! neuromast support cell differentiation
relationship: part_of GO:0048901 ! anterior lateral line neuromast development

[Term]
id: GO:0048907
name: anterior lateral line ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anterior lateral line ganglion over time, from its formation to the mature structure. The anterior lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509]
synonym: "gALL development" EXACT []
is_a: GO:0048890 ! lateral line ganglion development
relationship: part_of GO:0048898 ! anterior lateral line system development

[Term]
id: GO:0048908
name: anterior lateral line ganglion neuron differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron of the anterior lateral line ganglion." [PMID:15018940]
is_a: GO:0048891 ! lateral line ganglion neuron differentiation
relationship: part_of GO:0048907 ! anterior lateral line ganglion development

[Term]
id: GO:0048909
name: anterior lateral line nerve development
namespace: biological_process
alt_id: GO:0021734
def: "The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0125296509]
comment: This term was added by GO_REF:0000021.
synonym: "ALLN development" EXACT []
synonym: "nALL development" EXACT []
synonym: "rostral lateral line nerve development" EXACT []
is_a: GO:0048892 ! lateral line nerve development
relationship: part_of GO:0048898 ! anterior lateral line system development

[Term]
id: GO:0048910
name: afferent axon development in the anterior lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an afferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the anterior lateral line nerve." [PMID:15018940]
is_a: GO:0048893 ! afferent axon development in a lateral line nerve
relationship: part_of GO:0048909 ! anterior lateral line nerve development

[Term]
id: GO:0048911
name: efferent axon development in the anterior lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an efferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the anterior lateral line nerve." [PMID:15018940]
is_a: GO:0048894 ! efferent axon development in a lateral line nerve
relationship: part_of GO:0048909 ! anterior lateral line nerve development

[Term]
id: GO:0048912
name: glial cell migration in the anterior lateral line nerve
namespace: biological_process
def: "The movement of a glial cell along the axons in the anterior lateral line nerve." [PMID:12062041]
is_a: GO:0048896 ! glial cell migration in a lateral line nerve
relationship: part_of GO:0048909 ! anterior lateral line nerve development

[Term]
id: GO:0048913
name: anterior lateral line nerve glial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a glial cell in the anterior lateral line nerve." [PMID:15832385]
is_a: GO:0048895 ! lateral line nerve glial cell differentiation
relationship: part_of GO:0048909 ! anterior lateral line nerve development

[Term]
id: GO:0048914
name: myelination of anterior lateral line nerve axons
namespace: biological_process
def: "The formation of compact myelin sheaths around the axons of the anterior lateral line nerve." [PMID:12112375]
is_a: GO:0048897 ! myelination of lateral line nerve axons
relationship: part_of GO:0048940 ! anterior lateral line nerve glial cell morphogenesis involved in differentiation

[Term]
id: GO:0048915
name: posterior lateral line system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior lateral line system over time, from its formation to the mature structure. The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940]
synonym: "PLL" RELATED []
is_a: GO:0048925 ! lateral line system development
relationship: part_of GO:0048881 ! mechanosensory lateral line system development

[Term]
id: GO:0048916
name: posterior lateral line development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior lateral line over time, from its formation to the mature structure. The posterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the body and trunk of all fishes and most amphibians. The posterior lateral line develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509]
synonym: "PLL development" EXACT []
is_a: GO:0048882 ! lateral line development
relationship: part_of GO:0048915 ! posterior lateral line system development

[Term]
id: GO:0048917
name: posterior lateral line ganglion development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior lateral line ganglion over time, from its formation to the mature structure. The posterior lateral line ganglion develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509, ISBN:0387968377]
synonym: "gPLL development" EXACT []
is_a: GO:0048890 ! lateral line ganglion development
relationship: part_of GO:0048915 ! posterior lateral line system development

[Term]
id: GO:0048918
name: posterior lateral line nerve development
namespace: biological_process
alt_id: GO:0021733
def: "The process whose specific outcome is the progression of the posterior lateral line nerve over time, form its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jic, GOC:mtg_15jun06, ISBN:0125296509]
comment: This term was added by GO_REF:0000021.
synonym: "caudal lateral line nerve development" EXACT []
synonym: "PLLN development" EXACT []
is_a: GO:0048892 ! lateral line nerve development
relationship: part_of GO:0048915 ! posterior lateral line system development

[Term]
id: GO:0048919
name: posterior lateral line neuromast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509]
is_a: GO:0048884 ! neuromast development
relationship: part_of GO:0048916 ! posterior lateral line development

[Term]
id: GO:0048920
name: posterior lateral line neuromast primordium migration
namespace: biological_process
def: "The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop." [GOC:dgh, PMID:15832385]
synonym: "PLL neuromast primordium migration" EXACT []
is_a: GO:0048883 ! neuromast primordium migration
relationship: part_of GO:0048916 ! posterior lateral line development

[Term]
id: GO:0048921
name: posterior lateral line neuromast cupula development
namespace: biological_process
def: "The process whose specific outcome is the progression of the posterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509]
is_a: GO:0048887 ! cupula development
relationship: part_of GO:0048919 ! posterior lateral line neuromast development

[Term]
id: GO:0048922
name: posterior lateral line neuromast deposition
namespace: biological_process
def: "The process by which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing posterior lateral line." [PMID:15832385]
is_a: GO:0048885 ! neuromast deposition
relationship: part_of GO:0048919 ! posterior lateral line neuromast development

[Term]
id: GO:0048923
name: posterior lateral line neuromast hair cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509]
is_a: GO:0048886 ! neuromast hair cell differentiation
relationship: part_of GO:0048919 ! posterior lateral line neuromast development

[Term]
id: GO:0048924
name: posterior lateral line neuromast mantle cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast mantle cell. (N.B. This may be development of neuromast mantle cell type or a set of cells of neuromast mantle cell type. This will involve the change of a cell or set of cells from one cell identity to another). Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509]
is_a: GO:0048888 ! neuromast mantle cell differentiation
relationship: part_of GO:0048919 ! posterior lateral line neuromast development

[Term]
id: GO:0048925
name: lateral line system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the lateral line system over time, from its formation to the mature structure. The lateral line system is a network of sensory organs (neuromasts) and lateral line nerves located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line system develops from cranial ectodermal placodes situated between the eye and ear." [GOC:dgh, ISBN:0125296509]
is_a: GO:0048880 ! sensory system development

[Term]
id: GO:0048926
name: electrosensory lateral line system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the electrosensory lateral line system over time, from its formation to the mature structure." [GOC:dgh]
is_a: GO:0048925 ! lateral line system development

[Term]
id: GO:0048927
name: posterior lateral line neuromast support cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377]
is_a: GO:0048889 ! neuromast support cell differentiation
relationship: part_of GO:0048919 ! posterior lateral line neuromast development

[Term]
id: GO:0048928
name: posterior lateral line ganglion neuron differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron of the posterior lateral line ganglion." [PMID:15018940]
is_a: GO:0048891 ! lateral line ganglion neuron differentiation
relationship: part_of GO:0048917 ! posterior lateral line ganglion development

[Term]
id: GO:0048929
name: efferent axon development in the posterior lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an efferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the posterior lateral line nerve." [PMID:15018940]
is_a: GO:0048894 ! efferent axon development in a lateral line nerve
relationship: part_of GO:0048918 ! posterior lateral line nerve development

[Term]
id: GO:0048930
name: glial cell migration in the posterior lateral line nerve
namespace: biological_process
def: "The movement of a glial cell along the axons in the posterior lateral line nerve." [PMID:12062041]
is_a: GO:0048896 ! glial cell migration in a lateral line nerve
relationship: part_of GO:0048918 ! posterior lateral line nerve development

[Term]
id: GO:0048931
name: posterior lateral line nerve glial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a glial cell in the posterior lateral line nerve." [PMID:15832385]
is_a: GO:0048895 ! lateral line nerve glial cell differentiation
relationship: part_of GO:0048918 ! posterior lateral line nerve development

[Term]
id: GO:0048932
name: myelination of posterior lateral line nerve axons
namespace: biological_process
def: "The formation of compact myelin sheaths around the axons of the posterior lateral line nerve." [PMID:12112375]
is_a: GO:0048897 ! myelination of lateral line nerve axons
relationship: part_of GO:0048942 ! posterior lateral line nerve glial cell morphogenesis involved in differentiation

[Term]
id: GO:0048933
name: afferent axon development in the posterior lateral line nerve
namespace: biological_process
def: "The process whose specific outcome is the progression of an afferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the posterior lateral line nerve." [PMID:15018940]
is_a: GO:0048893 ! afferent axon development in a lateral line nerve
relationship: part_of GO:0048918 ! posterior lateral line nerve development

[Term]
id: GO:0048934
name: peripheral nervous system neuron differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system." [GOC:dgh]
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0007422 ! peripheral nervous system development

[Term]
id: GO:0048935
name: peripheral nervous system neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh]
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0048934 ! peripheral nervous system neuron differentiation

[Term]
id: GO:0048936
name: peripheral nervous system neuron axonogenesis
namespace: biological_process
def: "Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells." [GOC:dgh]
is_a: GO:0007409 ! axonogenesis
relationship: part_of GO:0048935 ! peripheral nervous system neuron development

[Term]
id: GO:0048937
name: lateral line nerve glial cell development
namespace: biological_process
def: "The process aimed at the progression of a lateral line glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh]
is_a: GO:0021782 ! glial cell development
relationship: part_of GO:0048895 ! lateral line nerve glial cell differentiation

[Term]
id: GO:0048938
name: lateral line nerve glial cell morphogenesis involved in differentiation
namespace: biological_process
def: "The process by which the structure of a glial cell in a lateral line nerve is generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in a lateral line nerve." [GOC:dgh]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0048937 ! lateral line nerve glial cell development

[Term]
id: GO:0048939
name: anterior lateral line nerve glial cell development
namespace: biological_process
def: "The process aimed at the progression of a glial cell in the anterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh]
is_a: GO:0048937 ! lateral line nerve glial cell development
relationship: part_of GO:0048913 ! anterior lateral line nerve glial cell differentiation

[Term]
id: GO:0048940
name: anterior lateral line nerve glial cell morphogenesis involved in differentiation
namespace: biological_process
def: "The process by which the structures of a glial cell in the anterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the anterior lateral line nerve." [GOC:dgh]
is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation
relationship: part_of GO:0048939 ! anterior lateral line nerve glial cell development

[Term]
id: GO:0048941
name: posterior lateral line nerve glial cell development
namespace: biological_process
def: "The process aimed at the progression of a glial cell in the posterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh]
is_a: GO:0048937 ! lateral line nerve glial cell development
relationship: part_of GO:0048931 ! posterior lateral line nerve glial cell differentiation

[Term]
id: GO:0048942
name: posterior lateral line nerve glial cell morphogenesis involved in differentiation
namespace: biological_process
def: "The process by which the structures of a glial cell in the posterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the posterior lateral line nerve." [GOC:dgh]
is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation
relationship: part_of GO:0048941 ! posterior lateral line nerve glial cell development

[Term]
id: GO:0050000
name: chromosome localization
namespace: biological_process
def: "Any process by which a chromosome is transported to, or maintained in, a specific location." [GOC:ai]
synonym: "establishment and maintenance of chromosome localization" EXACT []
synonym: "establishment and maintenance of chromosome position" EXACT []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0050001
name: D-glutaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate." [EC:3.5.1.35, MetaCyc:D-GLUTAMINASE-RXN]
synonym: "D-glutamine amidohydrolase activity" EXACT [EC:3.5.1.35]
xref: EC:3.5.1.35
xref: MetaCyc:D-GLUTAMINASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050002
name: D-proline reductase (dithiol) activity
namespace: molecular_function
def: "Catalysis of the reaction: lipoate + 5-aminopentanoate = dihydrolipoate + D-proline." [EC:1.21.4.1, MetaCyc:D-PROLINE-REDUCTASE-(DITHIOL)-RXN]
comment: Note that this function was formerly EC:1.4.4.1.
synonym: "5-aminopentanoate:lipoate oxidoreductase (cyclizing)" EXACT [EC:1.21.4.1]
xref: EC:1.21.4.1
xref: MetaCyc:1.21.4.1-RXN
is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor

[Term]
id: GO:0050003
name: deoxycytidylate C-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = deoxy-5-methylcytidylate + 7,8-dihydrofolate." [EC:2.1.1.54, MetaCyc:DEOXYCYTIDYLATE-C-METHYLTRANSFERASE-RXN]
synonym: "5,10-methylenetetrahydrofolate:dCMP C-methyltransferase activity" EXACT [EC:2.1.1.54]
synonym: "dCMP methyltransferase activity" EXACT [EC:2.1.1.54]
synonym: "deoxycytidylate methyltransferase activity" EXACT [EC:2.1.1.54]
xref: EC:2.1.1.54
xref: MetaCyc:DEOXYCYTIDYLATE-C-METHYLTRANSFERASE-RXN
is_a: GO:0008169 ! C-methyltransferase activity

[Term]
id: GO:0050004
name: isoflavone 7-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside." [EC:2.4.1.170, MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN]
synonym: "UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.170]
synonym: "UDPglucose-flavonoid 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170]
synonym: "UDPglucose:isoflavone 7-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.170]
synonym: "UDPglucose:isoflavone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170]
synonym: "uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase activity" EXACT [EC:2.4.1.170]
xref: EC:2.4.1.170
xref: MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050005
name: isohexenylglutaconyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)-pent-2-enedioyl-CoA + H2O." [EC:4.2.1.57, MetaCyc:ISOHEXENYLGLUTACONYL-COA-HYDRATASE-RXN]
synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]" RELATED [EC:4.2.1.57]
synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase activity" EXACT [EC:4.2.1.57]
synonym: "3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase activity" EXACT [EC:4.2.1.57]
synonym: "beta-isohexenylglutaconyl-CoA-hydratase activity" EXACT [EC:4.2.1.57]
synonym: "isohexenylglutaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.57]
xref: EC:4.2.1.57
xref: MetaCyc:ISOHEXENYLGLUTACONYL-COA-HYDRATASE-RXN
xref: UM-BBD_enzymeID:e0722
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050006
name: isomaltulose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose." [EC:5.4.99.11, MetaCyc:ISOMALTULOSE-SYNTHASE-RXN]
synonym: "isomaltulose synthetase activity" EXACT [EC:5.4.99.11]
synonym: "sucrose alpha-glucosyltransferase activity" EXACT [EC:5.4.99.11]
synonym: "sucrose glucosylmutase activity" EXACT [EC:5.4.99.11]
synonym: "trehalulose synthase activity" EXACT [EC:5.4.99.11]
xref: EC:5.4.99.11
xref: MetaCyc:ISOMALTULOSE-SYNTHASE-RXN
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0050007
name: isonocardicin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + nocardicin E = 5'-methylthioadenosine + isonocardicin A." [EC:2.5.1.38, MetaCyc:ISONOCARDICIN-SYNTHASE-RXN]
synonym: "nocardicin aminocarboxypropyltransferase activity" EXACT [EC:2.5.1.38]
synonym: "S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.38]
xref: EC:2.5.1.38
xref: MetaCyc:ISONOCARDICIN-SYNTHASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050008
name: isopiperitenone delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: isopiperitenone = piperitenone." [EC:5.3.3.11, MetaCyc:ISOPIPERITENONE-DELTA-ISOMERASE-RXN]
synonym: "isopiperitenone D-isomerase activity" EXACT []
synonym: "isopiperitenone delta8-delta4-isomerase activity" EXACT [EC:5.3.3.11]
xref: EC:5.3.3.11
xref: MetaCyc:ISOPIPERITENONE-DELTA-ISOMERASE-RXN
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0050009
name: isopropanol dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: propan-2-ol + NADP+ = acetone + NADPH." [EC:1.1.1.80, MetaCyc:ISOPROPANOL-DEHYDROGENASE-NADP+-RXN]
synonym: "propan-2-ol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.80]
xref: EC:1.1.1.80
xref: MetaCyc:ISOPROPANOL-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050010
name: isovitexin beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + isovitexin = isovitexin 2''-O-beta-D-glucoside + UDP." [EC:2.4.1.106, MetaCyc:ISOVITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "isovitexin b-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:isovitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.106]
synonym: "UDPglucose:isovitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.106]
synonym: "uridine diphosphoglucose-isovitexin 2''-glucosyltransferase activity" EXACT [EC:2.4.1.106]
xref: EC:2.4.1.106
xref: MetaCyc:ISOVITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050011
name: itaconyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O." [EC:4.2.1.56, MetaCyc:ITACONYL-COA-HYDRATASE-RXN]
synonym: "citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)" EXACT [EC:4.2.1.56]
synonym: "citramalyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.56]
synonym: "itaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.56]
xref: EC:4.2.1.56
xref: MetaCyc:ITACONYL-COA-HYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050012
name: juglone 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-hydroxy-1,4-naphthoquinone + donor-H2 + O2 = 3,5-dihydroxy-1,4-naphthoquinone + acceptor + H2O." [EC:1.14.99.27, MetaCyc:JUGLONE-3-MONOOXYGENASE-RXN]
synonym: "5-hydroxy-1,4-naphthoquinone,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.99.27]
synonym: "juglone hydroxylase activity" EXACT []
synonym: "naphthoquinone hydroxylase activity" EXACT [EC:1.14.99.27]
synonym: "naphthoquinone-hydroxylase activity" EXACT [EC:1.14.99.27]
xref: EC:1.14.99.27
xref: MetaCyc:JUGLONE-3-MONOOXYGENASE-RXN
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050013
name: 2-dehydropantoate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde." [EC:4.1.2.12, MetaCyc:KETOPANTOALDOLASE-RXN]
synonym: "2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming)" EXACT [EC:4.1.2.12]
synonym: "2-dehydropantoate formaldehyde-lyase activity" EXACT [EC:4.1.2.12]
synonym: "ketopantoaldolase activity" EXACT []
xref: EC:4.1.2.12
xref: MetaCyc:KETOPANTOALDOLASE-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050014
name: ketotetrose-phosphate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: erythrulose 1-phosphate = glycerone phosphate + formaldehyde." [EC:4.1.2.2, MetaCyc:KETOTETROSE-PHOSPHATE-ALDOLASE-RXN]
synonym: "erythrose-1-phosphate synthase activity" EXACT [EC:4.1.2.2]
synonym: "erythrulose-1-phosphate formaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.2]
synonym: "erythrulose-1-phosphate formaldehyde-lyase activity" EXACT [EC:4.1.2.2]
synonym: "erythrulose-1-phosphate synthetase activity" EXACT [EC:4.1.2.2]
synonym: "phosphoketotetrose aldolase activity" EXACT [EC:4.1.2.2]
xref: EC:4.1.2.2
xref: MetaCyc:KETOTETROSE-PHOSPHATE-ALDOLASE-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050015
name: kievitone hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: kievitone hydrate = kievitone + H2O." [EC:4.2.1.95, MetaCyc:KIEVITONE-HYDRATASE-RXN]
synonym: "KHase activity" EXACT [EC:4.2.1.95]
synonym: "kievitone-hydrate hydro-lyase (kievitone-forming)" EXACT [EC:4.2.1.95]
synonym: "kievitone-hydrate hydro-lyase activity" EXACT [EC:4.2.1.95]
xref: EC:4.2.1.95
xref: MetaCyc:KIEVITONE-HYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050016
name: kynurenine 7,8-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor." [EC:1.14.99.2, MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN]
synonym: "kynurenate 7,8-hydroxylase activity" EXACT [EC:1.14.99.2]
synonym: "kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.99.2]
synonym: "kynurenic acid hydroxylase activity" EXACT [EC:1.14.99.2]
synonym: "kynurenic hydroxylase activity" EXACT [EC:1.14.99.2]
xref: EC:1.14.99.2
xref: MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050017
name: L-3-cyanoalanine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine." [EC:4.4.1.9, MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN]
synonym: "beta-cyano-L-alanine synthase activity" EXACT [EC:4.4.1.9]
synonym: "beta-cyanoalanine synthase activity" EXACT [EC:4.4.1.9]
synonym: "beta-cyanoalanine synthetase activity" EXACT [EC:4.4.1.9]
synonym: "L-cysteine hydrogen-sulfide-lyase (adding HCN)" EXACT [EC:4.4.1.9]
synonym: "L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)" EXACT [EC:4.4.1.9]
xref: EC:4.4.1.9
xref: MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0050018
name: L-amino-acid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH." [EC:1.4.1.5, MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN]
synonym: "L-amino-acid:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.5]
xref: EC:1.4.1.5
xref: MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050019
name: L-arabinitol 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinitol + NAD+ = L-xylulose + NADH." [EC:1.1.1.12, MetaCyc:L-ARABINITOL-4-DEHYDROGENASE-RXN]
xref: EC:1.1.1.12
xref: MetaCyc:L-ARABINITOL-4-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050020
name: L-arabinonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H2O." [EC:4.2.1.25, MetaCyc:L-ARABINONATE-DEHYDRATASE-RXN]
synonym: "L-arabinonate hydro-lyase (2-dehydro-3-deoxy-L-arabinonate-forming)" EXACT [EC:4.2.1.25]
synonym: "L-arabinonate hydro-lyase activity" EXACT [EC:4.2.1.25]
synonym: "L-arabonate dehydrase activity" EXACT [EC:4.2.1.25]
synonym: "L-arabonate dehydratase activity" EXACT [EC:4.2.1.25]
xref: EC:4.2.1.25
xref: MetaCyc:L-ARABINONATE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050021
name: L-arabinonolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinono-1,4-lactone + H2O = L-arabinonate." [EC:3.1.1.15, MetaCyc:L-ARABINONOLACTONASE-RXN]
synonym: "L-arabinono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.15]
xref: EC:3.1.1.15
xref: MetaCyc:L-ARABINONOLACTONASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050022
name: L-arabinose 1-dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH." [EC:1.1.1.46, MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN]
synonym: "L-arabinose 1-dehydrogenase activity" BROAD []
synonym: "L-arabinose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.46]
xref: EC:1.1.1.46
xref: MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050023
name: L-fuconate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O." [EC:4.2.1.68, MetaCyc:L-FUCONATE-HYDRATASE-RXN]
synonym: "L-fuconate hydratase activity" EXACT []
synonym: "L-fuconate hydro-lyase (2-dehydro-3-deoxy-L-fuconate-forming)" EXACT [EC:4.2.1.68]
synonym: "L-fuconate hydro-lyase activity" EXACT [EC:4.2.1.68]
xref: EC:4.2.1.68
xref: MetaCyc:L-FUCONATE-HYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050024
name: L-galactonolactone oxidase activity
namespace: molecular_function
alt_id: GO:0033733
def: "Catalysis of the reaction: L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2." [EC:1.3.3.12, MetaCyc:L-GALACTONOLACTONE-OXIDASE-RXN]
synonym: "L-galactono-1,4-lactone oxidase activity" EXACT [EC:1.3.3.12]
synonym: "L-galactono-1,4-lactone:oxygen 3-oxidoreductase activity" EXACT [EC:1.3.3.12]
synonym: "L-xylono-1,4-lactone oxidase activity" EXACT [EC:1.3.3.12]
xref: EC:1.3.3.12
xref: MetaCyc:1.3.3.12-RXN
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050025
name: L-glutamate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2." [EC:1.4.3.11, MetaCyc:L-GLUTAMATE-OXIDASE-RXN]
subset: gosubset_prok
synonym: "glutamate (acceptor) dehydrogenase activity" EXACT [EC:1.4.3.11]
synonym: "glutamate oxidase activity" EXACT [EC:1.4.3.11]
synonym: "glutamic acid oxidase activity" EXACT [EC:1.4.3.11]
synonym: "glutamic dehydrogenase (acceptor)" EXACT [EC:1.4.3.11]
synonym: "L-glutamate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.11]
synonym: "L-glutamic acid oxidase activity" EXACT [EC:1.4.3.11]
xref: EC:1.4.3.11
xref: MetaCyc:L-GLUTAMATE-OXIDASE-RXN
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0050026
name: L-glycol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+." [EC:1.1.1.185, MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN]
synonym: "glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity" EXACT [EC:1.1.1.185]
synonym: "L-(+)-glycol:NAD(P) oxidoreductase activity" EXACT [EC:1.1.1.185]
synonym: "L-glycol:NAD(P) dehydrogenase activity" EXACT [EC:1.1.1.185]
synonym: "L-glycol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.185]
xref: EC:1.1.1.185
xref: MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050027
name: L-idonate 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-idonate + NADP+ = 5-dehydro-D-gluconate + NADPH." [EC:1.1.1.128, MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN]
synonym: "5-keto-D-gluconate 2-reductase activity" EXACT [EC:1.1.1.128]
synonym: "5-ketogluconate 2-reductase activity" EXACT [EC:1.1.1.128]
synonym: "5-ketoglucono-idono-reductase activity" EXACT [EC:1.1.1.128]
synonym: "5KGR" RELATED [EC:1.1.1.128]
synonym: "L-idonate dehydrogenase activity" EXACT [EC:1.1.1.128]
synonym: "L-idonate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.128]
synonym: "reductase, 5-ketogluconate 5- (L-idonate-forming)" EXACT [EC:1.1.1.128]
xref: EC:1.1.1.128
xref: MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050028
name: L-lysine-lactamase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine 1,6-lactam + H2O = L-lysine." [EC:3.5.2.11, MetaCyc:L-LYSINE-LACTAMASE-RXN]
synonym: "L-alpha-aminocaprolactam hydrolase activity" EXACT [EC:3.5.2.11]
synonym: "L-lysinamidase activity" EXACT [EC:3.5.2.11]
synonym: "L-lysine-1,6-lactam lactamhydrolase activity" EXACT [EC:3.5.2.11]
xref: EC:3.5.2.11
xref: MetaCyc:L-LYSINE-LACTAMASE-RXN
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0050029
name: L-lysine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + H2O2." [EC:1.4.3.14, MetaCyc:L-LYSINE-OXIDASE-RXN]
synonym: "L-lysine alpha-oxidase activity" EXACT [EC:1.4.3.14]
synonym: "L-lysine:oxygen 2-oxidoreductase (deaminating)" EXACT [EC:1.4.3.14]
synonym: "L-lysyl-alpha-oxidase activity" EXACT [EC:1.4.3.14]
xref: EC:1.4.3.14
xref: MetaCyc:L-LYSINE-OXIDASE-RXN
xref: MetaCyc:PWY-5311
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0050030
name: L-pipecolate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-pipecolate + acceptor = 2,3,4,5-tetrahydropyridine-2-carboxylate + reduced acceptor." [EC:1.5.99.3, MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN]
synonym: "L-pipecolate:(acceptor) 1,6-oxidoreductase activity" EXACT [EC:1.5.99.3]
synonym: "L-pipecolate:acceptor 1,6-oxidoreductase activity" EXACT [EC:1.5.99.3]
xref: EC:1.5.99.3
xref: MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0050031
name: L-pipecolate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2." [EC:1.5.3.7, MetaCyc:L-PIPECOLATE-OXIDASE-RXN]
synonym: "L-pipecolate:oxygen 1,6-oxidoreductase activity" EXACT [EC:1.5.3.7]
synonym: "L-pipecolic acid oxidase activity" EXACT [EC:1.5.3.7]
xref: EC:1.5.3.7
xref: MetaCyc:L-PIPECOLATE-OXIDASE-RXN
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0050032
name: L-rhamnonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O." [EC:4.2.1.90, MetaCyc:L-RHAMNONATE-DEHYDRATASE-RXN]
synonym: "L-rhamnonate hydro-lyase (2-dehydro-3-deoxy-L-rhamnonate-forming)" EXACT [EC:4.2.1.90]
synonym: "L-rhamnonate hydro-lyase activity" EXACT [EC:4.2.1.90]
xref: EC:4.2.1.90
xref: MetaCyc:L-RHAMNONATE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050033
name: L-rhamnono-1,4-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-rhamnono-1,4-lactone + H2O = L-rhamnonate." [EC:3.1.1.65, MetaCyc:L-RHAMNONO-14-LACTONASE-RXN]
synonym: "L-rhamno-gamma-lactonase activity" EXACT [EC:3.1.1.65]
synonym: "L-rhamnono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.65]
synonym: "L-rhamnono-gamma-lactonase activity" EXACT [EC:3.1.1.65]
xref: EC:3.1.1.65
xref: MetaCyc:L-RHAMNONO-14-LACTONASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050034
name: L-rhamnose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-rhamnofuranose + NAD+ = L-rhamno-1,4-lactone + NADH." [EC:1.1.1.173, MetaCyc:L-RHAMNOSE-1-DEHYDROGENASE-RXN]
synonym: "L-rhamnofuranose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.173]
xref: EC:1.1.1.173
xref: MetaCyc:L-RHAMNOSE-1-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050035
name: L-sorbose oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-sorbose + O2 = 5-dehydro-D-fructose + H2O2." [EC:1.1.3.11, MetaCyc:L-SORBOSE-OXIDASE-RXN]
synonym: "L-sorbose:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.11]
xref: EC:1.1.3.11
xref: MetaCyc:L-SORBOSE-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050036
name: L-threonate 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threonate + NAD+ = 3-dehydro-L-threonate + NADH." [EC:1.1.1.129, MetaCyc:L-THREONATE-3-DEHYDROGENASE-RXN]
synonym: "L-threonate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.129]
synonym: "L-threonic acid dehydrogenase activity" EXACT [EC:1.1.1.129]
synonym: "threonate dehydrogenase activity" EXACT [EC:1.1.1.129]
xref: EC:1.1.1.129
xref: MetaCyc:L-THREONATE-3-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050037
name: L-xylose 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-xylose + NADP+ = L-xylono-1,4-lactone + NADPH." [EC:1.1.1.113, MetaCyc:L-XYLOSE-1-DEHYDROGENASE-RXN]
synonym: "L-xylose dehydrogenase activity" EXACT [EC:1.1.1.113]
synonym: "L-xylose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.113]
synonym: "NADPH-xylose reductase activity" EXACT [EC:1.1.1.113]
xref: EC:1.1.1.113
xref: MetaCyc:L-XYLOSE-1-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050038
name: L-xylulose reductase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: xylitol + NADP+ = L-xylulose + NADPH." [EC:1.1.1.10, MetaCyc:L-XYLULOSE-REDUCTASE-RXN]
synonym: "L-xylulose reductase activity" BROAD []
xref: EC:1.1.1.10
xref: MetaCyc:L-XYLULOSE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050039
name: lactaldehyde reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: propane-1,2-diol + NADP+ = L-lactaldehyde + NADPH." [EC:1.1.1.55, MetaCyc:LACTALDEHYDE-REDUCTASE-NADPH-RXN]
synonym: "1,2-propanediol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.55]
synonym: "lactaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.1.1.55]
synonym: "NADP-1,2-propanediol dehydrogenase activity" EXACT [EC:1.1.1.55]
synonym: "propane-1,2-diol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.55]
synonym: "propanediol dehydrogenase activity" EXACT [EC:1.1.1.55]
xref: EC:1.1.1.55
xref: MetaCyc:LACTALDEHYDE-REDUCTASE-NADPH-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050040
name: lactate 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate + O2 = acetate + CO2 + H2O." [EC:1.13.12.4, MetaCyc:LACTATE-2-MONOOXYGENASE-RXN]
subset: gosubset_prok
synonym: "(S)-lactate:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.4]
synonym: "L-lactate monooxygenase activity" EXACT [EC:1.13.12.4]
synonym: "L-lactate-2-monooxygenase activity" EXACT [EC:1.13.12.4]
synonym: "lactate monooxygenase activity" EXACT [EC:1.13.12.4]
synonym: "lactate oxidase activity" EXACT [EC:1.13.12.4]
synonym: "lactate oxidative decarboxylase activity" EXACT [EC:1.13.12.4]
synonym: "lactate oxygenase activity" EXACT [EC:1.13.12.4]
synonym: "lactic oxidase activity" EXACT [EC:1.13.12.4]
synonym: "lactic oxygenase activity" EXACT [EC:1.13.12.4]
xref: EC:1.13.12.4
xref: MetaCyc:LACTATE-2-MONOOXYGENASE-RXN
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0050041
name: lactate aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate = formate + acetaldehyde." [EC:4.1.2.36, MetaCyc:LACTATE-ALDOLASE-RXN]
synonym: "(S)-lactate acetaldehyde-lyase (formate-forming)" EXACT [EC:4.1.2.36]
synonym: "(S)-lactate acetaldehyde-lyase activity" EXACT [EC:4.1.2.36]
synonym: "lactate synthase activity" EXACT [EC:4.1.2.36]
xref: EC:4.1.2.36
xref: MetaCyc:LACTATE-ALDOLASE-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050042
name: lactate-malate transhydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate + oxaloacetate = pyruvate + malate." [EC:1.1.99.7, MetaCyc:LACTATE-MALATE-TRANSHYDROGENASE-RXN]
synonym: "(S)-lactate:oxaloacetate oxidoreductase activity" EXACT [EC:1.1.99.7]
synonym: "malate-lactate transhydrogenase activity" EXACT [EC:1.1.99.7]
xref: EC:1.1.99.7
xref: MetaCyc:LACTATE-MALATE-TRANSHYDROGENASE-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0050043
name: lactate racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-lactate = (R)-lactate." [EC:5.1.2.1, MetaCyc:LACTATE-RACEMASE-RXN]
synonym: "hydroxyacid racemase activity" EXACT [EC:5.1.2.1]
synonym: "lactic acid racemase activity" EXACT [EC:5.1.2.1]
synonym: "lacticoracemase activity" EXACT [EC:5.1.2.1]
xref: EC:5.1.2.1
xref: MetaCyc:LACTATE-RACEMASE-RXN
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0050044
name: galactose-6-phosphate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate." [EC:5.3.1.26, MetaCyc:LACTOSE-6-PHOSPHATE-ISOMERASE-RXN]
subset: gosubset_prok
synonym: "D-galactose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.26]
synonym: "D-galactose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.26]
xref: EC:5.3.1.26
xref: MetaCyc:LACTOSE-6-PHOSPHATE-ISOMERASE-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0050045
name: laminaribiose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate." [EC:2.4.1.31, MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN]
synonym: "3-beta-D-glucosyl-D-glucose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.31]
xref: EC:2.4.1.31
xref: MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0050046
name: lathosterol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol + O2 = cholesta-5,7-dien-3-beta-ol + H2O2." [EC:1.14.21.6, MetaCyc:LATHOSTEROL-OXIDASE-RXN]
synonym: "5-DES" RELATED [EC:1.14.21.6]
synonym: "5alpha-cholest-7-en-3beta-ol, NAD(P)H:oxygen 5-oxidoreductase activity" EXACT [EC:1.14.21.6]
synonym: "delta7-sterol 5-desaturase activity" EXACT [EC:1.14.21.6]
synonym: "delta7-sterol delta5-dehydrogenase activity" EXACT [EC:1.14.21.6]
synonym: "delta7-sterol-C5(6)-desaturase activity" EXACT [EC:1.14.21.6]
synonym: "lathosterol 5-desaturase activity" EXACT [EC:1.14.21.6]
xref: EC:1.14.21.6
xref: MetaCyc:1.14.21.6-RXN
is_a: GO:0046996 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated
is_a: GO:0070704 ! sterol desaturase activity

[Term]
id: GO:0050047
name: leucine 2,3-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: (2S)-alpha-leucine = (3R)-beta-leucine." [EC:5.4.3.7, MetaCyc:LEUCINE-23-AMINOMUTASE-RXN]
synonym: "(2S)-alpha-leucine 2,3-aminomutase activity" EXACT [EC:5.4.3.7]
xref: EC:5.4.3.7
xref: MetaCyc:LEUCINE-23-AMINOMUTASE-RXN
is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups

[Term]
id: GO:0050048
name: L-leucine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate." [EC:2.6.1.6, MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN]
synonym: "L-leucine aminotransferase activity" BROAD [EC:2.6.1.6]
synonym: "leucine 2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.6]
synonym: "leucine aminotransferase activity" BROAD []
synonym: "leucine transaminase activity" BROAD [EC:2.6.1.6]
synonym: "leucine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.6]
xref: EC:2.6.1.6
xref: MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0050049
name: leucine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH." [EC:1.4.1.9, MetaCyc:LEUCINE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "L-leucine dehydrogenase activity" EXACT [EC:1.4.1.9]
synonym: "L-leucine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.9]
synonym: "L-leucine:NAD+ oxidoreductase, deaminating" EXACT [EC:1.4.1.9]
synonym: "LeuDH activity" EXACT [EC:1.4.1.9]
xref: EC:1.4.1.9
xref: MetaCyc:LEUCINE-DEHYDROGENASE-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050050
name: leucine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + L-leucine = CoA + N-acetyl-L-leucine." [EC:2.3.1.66, MetaCyc:LEUCINE-N-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA:L-leucine N-acetyltransferase activity" EXACT [EC:2.3.1.66]
synonym: "leucine acetyltransferase activity" EXACT [EC:2.3.1.66]
xref: EC:2.3.1.66
xref: MetaCyc:LEUCINE-N-ACETYLTRANSFERASE-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0050051
name: leukotriene-B4 20-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O." [EC:1.14.13.30, MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN]
synonym: "(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.13.30]
synonym: "leucotriene-B4 omega-hydroxylase activity" EXACT [EC:1.14.13.30]
synonym: "leukotriene-B(4) 20-hydroxylase activity" EXACT [EC:1.14.13.30]
synonym: "leukotriene-B(4) omega-hydroxylase activity" EXACT [EC:1.14.13.30]
synonym: "leukotriene-B4 20-hydroxylase activity" EXACT []
synonym: "leukotriene-B4 omega-hydroxylase activity" EXACT [EC:1.14.13.30]
synonym: "LTB(4) 20-hydroxylase activity" EXACT [EC:1.14.13.30]
synonym: "LTB(4) omega-hydroxylase activity" EXACT [EC:1.14.13.30]
synonym: "LTB4 20-hydroxylase activity" EXACT [EC:1.14.13.30]
synonym: "LTB4 omega-hydroxylase activity" EXACT [EC:1.14.13.30]
xref: EC:1.14.13.30
xref: MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050052
name: leukotriene-E4 20-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2 = 20-hydroxy-leucotriene E4 + NADP+ + H2O." [EC:1.14.13.34, MetaCyc:LEUKOTRIENE-E4-20-MONOOXYGENASE-RXN]
synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.13.34]
synonym: "leukotriene-E(4) omega-hydroxylase activity" EXACT [EC:1.14.13.34]
synonym: "leukotriene-E4 omega-hydroxylase activity" EXACT [EC:1.14.13.34]
synonym: "leukotriene-E4 w-hydroxylase activity" EXACT []
xref: EC:1.14.13.34
xref: MetaCyc:LEUKOTRIENE-E4-20-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050053
name: levansucrase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1)." [EC:2.4.1.10, MetaCyc:LEVANSUCRASE-RXN]
subset: gosubset_prok
synonym: "beta-2,6-fructan:D-glucose 1-fructosyltransferase activity" EXACT [EC:2.4.1.10]
synonym: "beta-2,6-fructosyltransferase activity" EXACT [EC:2.4.1.10]
synonym: "sucrose 6-fructosyl transferase activity" EXACT [EC:2.4.1.10]
synonym: "sucrose 6-fructosyltransferase activity" EXACT [EC:2.4.1.10]
synonym: "sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.10]
xref: EC:2.4.1.10
xref: MetaCyc:LEVANSUCRASE-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0050054
name: lignostilbene alpha beta-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethene + O2 = 2 vanillin." [EC:1.13.11.43, MetaCyc:LIGNOSTILBENE-ALPHA-BETA-DIOXYGENASE-RXN]
synonym: "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene:oxygen oxidoreductase (alphabeta-bond-cleaving)" EXACT [EC:1.13.11.43]
synonym: "lignostilbene ab-dioxygenase activity" EXACT []
synonym: "lignostilbene alphabeta-dioxygenase activity" EXACT [EC:1.13.11.43]
xref: EC:1.13.11.43
xref: MetaCyc:LIGNOSTILBENE-ALPHA-BETA-DIOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050055
name: limonin-D-ring-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate." [EC:3.1.1.36, MetaCyc:LIMONIN-D-RING-LACTONASE-RXN]
synonym: "limonin lactone hydrolase activity" EXACT [EC:3.1.1.36]
synonym: "limonin-D-ring-lactone hydrolase activity" EXACT [EC:3.1.1.36]
synonym: "limonoate-D-ring-lactone lactonohydrolase activity" EXACT [EC:3.1.1.36]
xref: EC:3.1.1.36
xref: MetaCyc:LIMONIN-D-RING-LACTONASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050056
name: linalool 8-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,7-dimethylocta-1,6-dien-3-ol + donor-H2 + O2 = (E)-3,7-dimethylocta-1,6-dien-3,8-diol + acceptor + H2O." [EC:1.14.99.28, MetaCyc:LINALOOL-8-MONOOXYGENASE-RXN]
subset: gosubset_prok
synonym: "3,7-dimethylocta-1,6-dien-3-ol,hydrogen-donor:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.99.28]
xref: EC:1.14.99.28
xref: MetaCyc:LINALOOL-8-MONOOXYGENASE-RXN
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050057
name: linamarin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin." [EC:2.4.1.63, MetaCyc:LINAMARIN-SYNTHASE-RXN]
synonym: "UDP glucose ketone cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.63]
synonym: "UDP-glucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.63]
synonym: "UDPglucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.63]
synonym: "UDPglucose:ketone cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.63]
synonym: "uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase activity" EXACT [EC:2.4.1.63]
synonym: "uridine diphosphoglucose-ketone cyanohydrin glucosyltransferase activity" EXACT [EC:2.4.1.63]
synonym: "uridine diphosphoglucose-ketone glucosyltransferase activity" EXACT [EC:2.4.1.63]
xref: EC:2.4.1.63
xref: MetaCyc:LINAMARIN-SYNTHASE-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0050058
name: linoleate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 9-cis,12-cis-octadecadienoate = 9-cis,11-trans-octadecadienoate." [EC:5.2.1.5, MetaCyc:LINOLEATE-ISOMERASE-RXN]
synonym: "linoleate delta12-cis-delta11-trans-isomerase activity" EXACT [EC:5.2.1.5]
synonym: "linoleic acid isomerase activity" EXACT [EC:5.2.1.5]
xref: EC:5.2.1.5
xref: MetaCyc:LINOLEATE-ISOMERASE-RXN
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0050059
name: lombricine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + lombricine = ADP + N-phospholombricine." [EC:2.7.3.5, MetaCyc:LOMBRICINE-KINASE-RXN]
synonym: "ATP:lombricine N-phosphotransferase activity" EXACT [EC:2.7.3.5]
xref: EC:2.7.3.5
xref: MetaCyc:LOMBRICINE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0050060
name: long-chain-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH." [EC:1.1.1.192, MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN]
synonym: "fatty alcohol oxidoreductase activity" EXACT [EC:1.1.1.192]
synonym: "long-chain alcohol dehydrogenase activity" EXACT [EC:1.1.1.192]
synonym: "long-chain-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.192]
xref: EC:1.1.1.192
xref: MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050061
name: long-chain-aldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+." [EC:1.2.1.48, MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN]
synonym: "fatty aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.48]
synonym: "long-chain aliphatic aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48]
synonym: "long-chain fatty aldehyde dehydrogenase activity" EXACT [EC:1.2.1.48]
synonym: "long-chain-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.48]
xref: EC:1.2.1.48
xref: MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN
xref: UM-BBD_enzymeID:e0874
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050062
name: long-chain-fatty-acyl-CoA reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH." [EC:1.2.1.50, MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN]
subset: gosubset_prok
synonym: "acyl coenzyme A reductase activity" EXACT [EC:1.2.1.50]
synonym: "long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming)" EXACT [EC:1.2.1.50]
xref: EC:1.2.1.50
xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050063
name: low-density-lipoprotein-receptor kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + low-density lipoprotein L-serine = ADP + low-density lipoprotein O-phospho-L-serine." [EC:2.7.11.29, MetaCyc:LOW-DENSITY-LIPOPROTEIN-KINASE-RXN]
synonym: "[low-density lipoprotein receptor] kinase activity" EXACT []
synonym: "ATP:low-density-lipoprotein receptor-L-serine O-phosphotransferase activity" EXACT [EC:2.7.11.29]
synonym: "ATP:low-density-lipoprotein-L-serine O-phosphotransferase activity" EXACT [EC:2.7.11.29]
synonym: "LDL receptor kinase activity" EXACT [EC:2.7.11.29]
synonym: "low-density lipoprotein receptor kinase activity" EXACT [EC:2.7.11.29]
synonym: "low-density-lipoprotein kinase activity" BROAD [EC:2.7.11.29]
synonym: "low-density-lipoprotein receptor kinase (phosphorylating) activity" EXACT [EC:2.7.11.29]
synonym: "STK7" RELATED [EC:2.7.11.29]
xref: EC:2.7.11.29
xref: MetaCyc:2.7.11.29-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0050064
name: luteolin 7-O-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucuronate + luteolin = UDP + luteolin 7-O-beta-D-glucuronide." [EC:2.4.1.189, MetaCyc:LUTEOLIN-7-O-GLUCORONOSYLTRANSFERASE-RXN]
synonym: "LGT" RELATED [EC:2.4.1.189]
synonym: "luteolin 7-O-glucoronosyltransferase activity" EXACT []
synonym: "UDP-glucuronate:luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189]
synonym: "UDPglucuronate:luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189]
synonym: "uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase activity" EXACT [EC:2.4.1.189]
xref: EC:2.4.1.189
xref: MetaCyc:LUTEOLIN-7-O-GLUCORONOSYLTRANSFERASE-RXN
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0050065
name: lysine-pyruvate 6-transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + pyruvate = 2-aminoadipate 6-semialdehyde + L-alanine." [EC:2.6.1.71, MetaCyc:LYSINE--PYRUVATE-6-AMINOTRANSFERASE-RXN]
synonym: "L-lysine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.71]
synonym: "Lys-AT" RELATED [EC:2.6.1.71]
synonym: "lysine--pyruvate 6-aminotransferase activity" EXACT []
synonym: "lysine-pyruvate aminotransferase activity" EXACT [EC:2.6.1.71]
xref: EC:2.6.1.71
xref: MetaCyc:LYSINE--PYRUVATE-6-AMINOTRANSFERASE-RXN
xref: MetaCyc:PWY-5324
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0050066
name: lysine 2,3-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate." [EC:5.4.3.2, MetaCyc:LYSINE-23-AMINOMUTASE-RXN, PMID:18307109]
subset: gosubset_prok
synonym: "L-lysine 2,3-aminomutase activity" EXACT [EC:5.4.3.2]
xref: EC:5.4.3.2
xref: MetaCyc:LYSINE-23-AMINOMUTASE-RXN
is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups
is_a: GO:0070283 ! radical SAM enzyme activity

[Term]
id: GO:0050067
name: lysine 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + O2 = 5-aminopentanamide + CO2 + H2O." [EC:1.13.12.2, MetaCyc:LYSINE-2-MONOOXYGENASE-RXN]
synonym: "L-lysine-2-monooxygenase activity" EXACT [EC:1.13.12.2]
synonym: "L-lysine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.2]
synonym: "lysine monooxygenase activity" EXACT [EC:1.13.12.2]
synonym: "lysine oxygenase activity" EXACT [EC:1.13.12.2]
xref: EC:1.13.12.2
xref: MetaCyc:LYSINE-2-MONOOXYGENASE-RXN
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0050068
name: lysine carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbamoyl phosphate + L-lysine = phosphate + L-homocitrulline." [EC:2.1.3.8, MetaCyc:LYSINE-CARBAMOYLTRANSFERASE-RXN]
synonym: "carbamoyl-phosphate:L-lysine carbamoyltransferase activity" EXACT [EC:2.1.3.8]
synonym: "lysine transcarbamylase activity" EXACT [EC:2.1.3.8]
xref: EC:2.1.3.8
xref: MetaCyc:LYSINE-CARBAMOYLTRANSFERASE-RXN
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0050069
name: lysine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH." [EC:1.4.1.15, MetaCyc:LYSINE-DEHYDROGENASE-RXN]
synonym: "L-lysine:NAD+ oxidoreductase (deaminating, cyclizing)" EXACT [EC:1.4.1.15]
xref: EC:1.4.1.15
xref: MetaCyc:LYSINE-DEHYDROGENASE-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050070
name: lysolecithin acylmutase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-lysolecithin = 3-lysolecithin." [EC:5.4.1.1, MetaCyc:LYSOLECITHIN-ACYLMUTASE-RXN]
synonym: "lysolecithin 2,3-acylmutase activity" EXACT [EC:5.4.1.1]
synonym: "lysolecithin migratase activity" RELATED [EC:5.4.1.1]
xref: EC:5.4.1.1
xref: MetaCyc:LYSOLECITHIN-ACYLMUTASE-RXN
is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups

[Term]
id: GO:0050071
name: lysyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-lysyl-tRNA + phosphatidylglycerol = tRNA + 3-phosphatidyl-1'-(3'-O-L-lysyl)glycerol." [EC:2.3.2.3, MetaCyc:LYSYLTRANSFERASE-RXN]
subset: gosubset_prok
synonym: "L-lysyl-tRNA:phosphatidylglycerol 3-O-lysyltransferase activity" EXACT [EC:2.3.2.3]
synonym: "L-lysyl-tRNA:phosphatidylglycerol O3-lysyltransferase activity" EXACT [EC:2.3.2.3]
xref: EC:2.3.2.3
xref: MetaCyc:LYSYLTRANSFERASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0050072
name: m7G(5')pppN diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [EC:3.6.1.30, MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN]
synonym: "7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [EC:3.6.1.30]
synonym: "decapase activity" RELATED [EC:3.6.1.30]
synonym: "M(7)G(5')pppN pyrophosphatase activity" EXACT []
synonym: "m7G(5')pppN pyrophosphatase activity" EXACT [EC:3.6.1.30]
xref: EC:3.6.1.30
xref: MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0050073
name: macrolide 2'-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + oleandomycin = ADP + oleandomycin 2'-O-phosphate." [EC:2.7.1.136, MetaCyc:MACROLIDE-2-KINASE-RXN]
synonym: "ATP:macrolide 2'-O-phosphotransferase activity" EXACT [EC:2.7.1.136]
xref: EC:2.7.1.136
xref: MetaCyc:MACROLIDE-2-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050074
name: malate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA." [EC:6.2.1.9, MetaCyc:MALATE--COA-LIGASE-RXN]
subset: gosubset_prok
synonym: "malate thiokinase activity" RELATED [EC:6.2.1.9]
synonym: "malate:CoA ligase (ADP-forming)" EXACT [EC:6.2.1.9]
synonym: "malyl coenzyme A synthetase activity" EXACT [EC:6.2.1.9]
synonym: "malyl-CoA synthetase activity" EXACT [EC:6.2.1.9]
xref: EC:6.2.1.9
xref: MetaCyc:MALATE--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0050075
name: maleate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-malate = maleate + H2O." [EC:4.2.1.31, MetaCyc:MALEATE-HYDRATASE-RXN]
synonym: "(R)-malate hydro-lyase (maleate-forming)" EXACT [EC:4.2.1.31]
synonym: "(R)-malate hydro-lyase activity" EXACT [EC:4.2.1.31]
synonym: "D-malate hydro-lyase activity" EXACT [EC:4.2.1.31]
synonym: "malease activity" EXACT [EC:4.2.1.31]
xref: EC:4.2.1.31
xref: MetaCyc:MALEATE-HYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050076
name: maleate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: maleate = fumarate." [EC:5.2.1.1, MetaCyc:MALEATE-ISOMERASE-RXN]
subset: gosubset_prok
synonym: "maleate cis-trans-isomerase activity" EXACT [EC:5.2.1.1]
xref: EC:5.2.1.1
xref: MetaCyc:MALEATE-ISOMERASE-RXN
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0050077
name: maleylpyruvate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate." [EC:5.2.1.4, MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN]
subset: gosubset_prok
synonym: "3-maleylpyruvate cis-trans-isomerase activity" EXACT [EC:5.2.1.4]
xref: EC:5.2.1.4
xref: MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0050078
name: malonate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA." [EC:2.8.3.3, MetaCyc:MALONATE-COA-TRANSFERASE-RXN]
synonym: "acetyl-CoA:malonate CoA-transferase activity" EXACT [EC:2.8.3.3]
synonym: "malonate coenzyme A-transferase activity" EXACT [EC:2.8.3.3]
xref: EC:2.8.3.3
xref: MetaCyc:MALONATE-COA-TRANSFERASE-RXN
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0050079
name: acetylenecarboxylate hydratase activity, producing 3-oxopropanoate
namespace: molecular_function
alt_id: GO:0047607
def: "Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O." [EC:4.2.1.27, MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN]
comment: Note that this function was formerly EC:4.2.1.71.
synonym: "3-oxopropanoate hydro-lyase (propynoate-forming)" EXACT [EC:4.2.1.27]
synonym: "3-oxopropanoate hydro-lyase activity" EXACT [EC:4.2.1.27]
synonym: "acetylenecarboxylate hydratase activity" BROAD []
synonym: "acetylenecarboxylate hydratase activity, producing malonate-semialdehyde" EXACT []
synonym: "acetylenemonocarboxylate hydrase activity" EXACT [EC:4.2.1.27]
synonym: "acetylenemonocarboxylate hydratase activity" BROAD []
synonym: "acetylmonocarboxylic acid hydrase activity" EXACT [EC:4.2.1.27]
synonym: "alkynoate hydratase activity" BROAD []
synonym: "malonate-semialdehyde dehydratase activity" EXACT []
xref: EC:4.2.1.27
xref: MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050080
name: malonyl-CoA decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2." [EC:4.1.1.9, MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN]
subset: gosubset_prok
synonym: "malonyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.9]
synonym: "malonyl-CoA carboxy-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.1.9]
synonym: "malonyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.9]
xref: EC:4.1.1.9
xref: MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050081
name: maltose-6'-phosphate glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.122, MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN]
subset: gosubset_prok
synonym: "maltose-6'-phosphate 6-phosphoglucohydrolase activity" EXACT [EC:3.2.1.122]
synonym: "phospho-alpha-glucosidase activity" EXACT [EC:3.2.1.122]
xref: EC:3.2.1.122
xref: MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0050082
name: maltose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.8, MetaCyc:MALTOSE-PHOSPHORYLASE-RXN]
subset: gosubset_prok
synonym: "maltose:phosphate 1-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.8]
xref: EC:2.4.1.8
xref: MetaCyc:MALTOSE-PHOSPHORYLASE-RXN
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0050083
name: malyl-CoA lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate." [EC:4.1.3.24, MetaCyc:MALYL-COA-LYASE-RXN]
synonym: "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.24]
synonym: "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase activity" EXACT [EC:4.1.3.24]
synonym: "malyl-coenzyme A lyase activity" EXACT [EC:4.1.3.24]
xref: EC:4.1.3.24
xref: MetaCyc:MALYL-COA-LYASE-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0050084
name: mannitol-1-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol 1-phosphate + H2O = D-mannitol + phosphate." [EC:3.1.3.22, MetaCyc:MANNITOL-1-PHOSPHATASE-RXN]
synonym: "D-mannitol-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.22]
synonym: "mannitol-1-phosphate phosphatase activity" EXACT [EC:3.1.3.22]
xref: EC:3.1.3.22
xref: MetaCyc:MANNITOL-1-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050085
name: mannitol 2-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol + NADP+ = D-fructose + NADPH." [EC:1.1.1.138, MetaCyc:MANNITOL-2-DEHYDROGENASE-NADP+-RXN]
synonym: "D-mannitol:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.138]
synonym: "NADP-dependent mannitol dehydrogenase activity" EXACT [EC:1.1.1.138]
xref: EC:1.1.1.138
xref: MetaCyc:MANNITOL-2-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050086
name: mannitol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH." [EC:1.1.1.67, MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "D-mannitol dehydrogenase activity" EXACT [EC:1.1.1.67]
synonym: "D-mannitol:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.67]
xref: EC:1.1.1.67
xref: MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050087
name: mannitol dehydrogenase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol + ferricytochrome c = D-fructose + ferrocytochrome c." [EC:1.1.2.2, MetaCyc:MANNITOL-DEHYDROGENASE-CYTOCHROME-RXN]
synonym: "D-mannitol:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.2]
synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.2.2]
xref: EC:1.1.2.2
xref: MetaCyc:MANNITOL-DEHYDROGENASE-CYTOCHROME-RXN
is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor

[Term]
id: GO:0050088
name: mannose-6-phosphate 6-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannitol 1-phosphate + NADP+ = D-mannose 6-phosphate + NADPH." [EC:1.1.1.224, MetaCyc:MANNOSE-6-PHOSPHATE-6-REDUCTASE-RXN]
synonym: "6-phosphomannose reductase activity" EXACT [EC:1.1.1.224]
synonym: "D-mannitol-1-phosphate:NADP+ 6-oxidoreductase activity" EXACT [EC:1.1.1.224]
synonym: "mannose-6-phosphate reductase activity" EXACT [EC:1.1.1.224]
synonym: "NADP-dependent mannose-6-P:mannitol-1-P oxidoreductase activity" EXACT [EC:1.1.1.224]
synonym: "NADPH-dependent M6P reductase activity" EXACT [EC:1.1.1.224]
synonym: "NADPH-dependent mannose 6-phosphate reductase activity" EXACT [EC:1.1.1.224]
synonym: "NADPH-mannose-6-P reductase activity" EXACT [EC:1.1.1.224]
xref: EC:1.1.1.224
xref: MetaCyc:MANNOSE-6-PHOSPHATE-6-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050089
name: mannose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannose = D-fructose." [EC:5.3.1.7, MetaCyc:MANNOSE-ISOMERASE-RXN]
synonym: "D-mannose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.7]
synonym: "D-mannose isomerase activity" EXACT [EC:5.3.1.7]
synonym: "D-mannose ketol-isomerase activity" EXACT [EC:5.3.1.7]
xref: EC:5.3.1.7
xref: MetaCyc:MANNOSE-ISOMERASE-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0050090
name: mannuronate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+." [EC:1.1.1.131, MetaCyc:MANNURONATE-REDUCTASE-RXN]
synonym: "D-mannonate:NAD(P)+ 6-oxidoreductase activity" EXACT [EC:1.1.1.131]
synonym: "D-mannonate:nicotinamide adenine dinucleotide (phosphate oxidoreductase (D-mannuronate-forming))" EXACT [EC:1.1.1.131]
synonym: "mannonate (nicotinamide adenine dinucleotide (phosphate))dehydrogenase activity" EXACT [EC:1.1.1.131]
synonym: "mannonate dehydrogenase (NAD(P)+)" EXACT [EC:1.1.1.131]
synonym: "mannonate dehydrogenase activity" EXACT [EC:1.1.1.131]
xref: EC:1.1.1.131
xref: MetaCyc:MANNURONATE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050091
name: melilotate 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NADH + O2 = 3-(2,3-dihydroxyphenyl)propanoate + NAD+ + H2O." [EC:1.14.13.4, MetaCyc:MELILOTATE-3-MONOOXYGENASE-RXN]
synonym: "2-hydroxyphenylpropionate hydroxylase activity" EXACT [EC:1.14.13.4]
synonym: "2-hydroxyphenylpropionic hydroxylase activity" EXACT [EC:1.14.13.4]
synonym: "3-(2-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.4]
synonym: "melilotate hydroxylase activity" EXACT []
synonym: "melilotic hydroxylase activity" EXACT [EC:1.14.13.4]
xref: EC:1.14.13.4
xref: MetaCyc:MELILOTATE-3-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050092
name: meso-tartrate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: meso-tartrate + NAD+ = dihydroxyfumarate + NADH." [EC:1.3.1.7, MetaCyc:MESO-TARTRATE-DEHYDROGENASE-RXN]
synonym: "meso-tartrate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.7]
xref: EC:1.3.1.7
xref: MetaCyc:MESO-TARTRATE-DEHYDROGENASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050093
name: methanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methanol + NAD+ = formaldehyde + NADH." [EC:1.1.1.244, MetaCyc:METHANOL-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "methanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.244]
xref: EC:1.1.1.244
xref: MetaCyc:METHANOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050094
name: methionine-glyoxylate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine." [EC:2.6.1.73, MetaCyc:METHIONINE--GLYOXYLATE-TRANSAMINASE-RXN]
synonym: "L-methionine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.73]
synonym: "methionine-glyoxylate aminotransferase activity" EXACT [EC:2.6.1.73]
synonym: "MGAT activity" EXACT [EC:2.6.1.73]
xref: EC:2.6.1.73
xref: MetaCyc:METHIONINE--GLYOXYLATE-TRANSAMINASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0050095
name: methionine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine = 3-methylthiopropanamine + CO2." [EC:4.1.1.57, MetaCyc:METHIONINE-DECARBOXYLASE-RXN]
synonym: "L-methionine carboxy-lyase (3-methylthiopropanamine-forming)" EXACT [EC:4.1.1.57]
synonym: "L-methionine carboxy-lyase activity" EXACT [EC:4.1.1.57]
synonym: "L-methionine decarboxylase activity" EXACT [EC:4.1.1.57]
xref: EC:4.1.1.57
xref: MetaCyc:METHIONINE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050096
name: methylaspartate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threo-3-methylaspartate = mesaconate + NH3." [EC:4.3.1.2, MetaCyc:METHYLASPARTATE-AMMONIA-LYASE-RXN]
subset: gosubset_prok
synonym: "3-methylaspartase activity" EXACT [EC:4.3.1.2]
synonym: "beta-methylaspartase activity" EXACT [EC:4.3.1.2]
synonym: "L-threo-3-methylaspartate ammonia-lyase (mesaconate-forming)" EXACT [EC:4.3.1.2]
synonym: "L-threo-3-methylaspartate ammonia-lyase activity" EXACT [EC:4.3.1.2]
xref: EC:4.3.1.2
xref: MetaCyc:METHYLASPARTATE-AMMONIA-LYASE-RXN
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0050097
name: methylaspartate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threo-3-methylaspartate = L-glutamate." [EC:5.4.99.1, MetaCyc:METHYLASPARTATE-MUTASE-RXN]
subset: gosubset_prok
synonym: "b-methylaspartate-glutamate mutase activity" EXACT [EC:5.4.99.1]
synonym: "beta-methylaspartate-glutamate mutase activity" EXACT [EC:5.4.99.1]
synonym: "glutamate isomerase activity" EXACT [EC:5.4.99.1]
synonym: "glutamate mutase activity" EXACT [EC:5.4.99.1]
synonym: "glutamic acid isomerase activity" EXACT [EC:5.4.99.1]
synonym: "glutamic acid mutase activity" EXACT [EC:5.4.99.1]
synonym: "glutamic isomerase activity" EXACT [EC:5.4.99.1]
synonym: "glutamic mutase activity" EXACT [EC:5.4.99.1]
synonym: "L-threo-3-methylaspartate carboxy-aminomethylmutase activity" EXACT [EC:5.4.99.1]
synonym: "methylaspartic acid mutase activity" EXACT [EC:5.4.99.1]
xref: EC:5.4.99.1
xref: MetaCyc:METHYLASPARTATE-MUTASE-RXN
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0050098
name: methylguanidinase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylguanidine + H2O = methylamine + urea." [EC:3.5.3.16, MetaCyc:METHYLGUANIDINASE-RXN]
synonym: "methylguanidine amidinohydrolase activity" EXACT [EC:3.5.3.16]
synonym: "methylguanidine hydrolase activity" EXACT [EC:3.5.3.16]
xref: EC:3.5.3.16
xref: MetaCyc:METHYLGUANIDINASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0050099
name: methylglutamate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methyl-L-glutamate + acceptor + H2O = L-glutamate + formaldehyde + reduced acceptor." [EC:1.5.99.5, MetaCyc:METHYLGUTAMATE-DEHYDROGENASE-RXN]
synonym: "N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.99.5]
synonym: "N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.99.5]
synonym: "N-methylglutamate dehydrogenase activity" EXACT [EC:1.5.99.5]
xref: EC:1.5.99.5
xref: MetaCyc:METHYLGUTAMATE-DEHYDROGENASE-RXN
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0050100
name: methylitaconate delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylitaconate = dimethylmaleate." [EC:5.3.3.6, MetaCyc:METHYLITACONATE-DELTA-ISOMERASE-RXN]
synonym: "methylitaconate D-isomerase activity" EXACT []
synonym: "methylitaconate delta2-delta3-isomerase activity" EXACT [EC:5.3.3.6]
synonym: "methylitaconate isomerase activity" EXACT [EC:5.3.3.6]
xref: EC:5.3.3.6
xref: MetaCyc:METHYLITACONATE-DELTA-ISOMERASE-RXN
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0050101
name: mimosinase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate + H2O = 3-hydroxy-4H-pyrid-4-one + L-serine." [EC:3.5.1.61, MetaCyc:MIMOSINASE-RXN]
synonym: "mimosine amidohydrolase activity" EXACT [EC:3.5.1.61]
xref: EC:3.5.1.61
xref: MetaCyc:MIMOSINASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050102
name: cellodextrin phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.49, MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN]
subset: gosubset_prok
synonym: "1,4-beta-D-oligo-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.49]
synonym: "beta-1,4-oligoglucan:orthophosphate glucosyltransferase activity" EXACT [EC:2.4.1.49]
xref: EC:2.4.1.49
xref: MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0050103
name: dextrin dextranase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1)." [EC:2.4.1.2, MetaCyc:DEXTRIN-DEXTRANASE-RXN]
synonym: "1,4-alpha-D-glucan:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.2]
synonym: "dextran dextrinase activity" EXACT [EC:2.4.1.2]
synonym: "dextrin 6-glucosyltransferase activity" EXACT [EC:2.4.1.2]
xref: EC:2.4.1.2
xref: MetaCyc:DEXTRIN-DEXTRANASE-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0050104
name: L-gulonate 3-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH." [EC:1.1.1.45, MetaCyc:L-GULONATE-3-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "L-3-aldonate dehydrogenase activity" EXACT [EC:1.1.1.45]
synonym: "L-3-aldonic dehydrogenase activity" EXACT [EC:1.1.1.45]
synonym: "L-3-hydroxyacid dehydrogenase activity" EXACT [EC:1.1.1.45]
synonym: "L-beta-hydroxy-acid-NAD-oxidoreductase activity" EXACT [EC:1.1.1.45]
synonym: "L-beta-hydroxyacid dehydrogenase activity" EXACT [EC:1.1.1.45]
synonym: "L-gulonate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.45]
synonym: "L-gulonic acid dehydrogenase activity" EXACT [EC:1.1.1.45]
xref: EC:1.1.1.45
xref: MetaCyc:L-GULONATE-3-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050105
name: L-gulonolactone oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2." [EC:1.1.3.8, MetaCyc:L-GULONOLACTONE-OXIDASE-RXN]
subset: gosubset_prok
synonym: "GLO activity" EXACT [EC:1.1.3.8]
synonym: "L-gulono-1,4-lactone:oxygen 3-oxidoreductase activity" EXACT [EC:1.1.3.8]
synonym: "L-gulono-gamma-lactone oxidase activity" EXACT [EC:1.1.3.8]
synonym: "L-gulono-gamma-lactone:O2 oxidoreductase activity" EXACT [EC:1.1.3.8]
synonym: "L-gulono-gamma-lactone:oxidoreductase activity" EXACT [EC:1.1.3.8]
xref: EC:1.1.3.8
xref: MetaCyc:L-GULONOLACTONE-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050106
name: monomethyl-sulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: monomethyl sulfate + H2O = methanol + SO4(2-) (sulfate)." [EC:3.1.6.16, MetaCyc:MONOMETHYL-SULFATASE-RXN]
synonym: "monomethyl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.16]
synonym: "monomethyl-sulphatase activity" EXACT []
xref: EC:3.1.6.16
xref: MetaCyc:MONOMETHYL-SULFATASE-RXN
is_a: GO:0008484 ! sulfuric ester hydrolase activity

[Term]
id: GO:0050107
name: monoterpenol O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester." [EC:2.3.1.69, MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA:monoterpenol O-acetyltransferase activity" EXACT [EC:2.3.1.69]
synonym: "menthol transacetylase activity" NARROW [EC:2.3.1.69]
xref: EC:2.3.1.69
xref: MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050108
name: monoterpenyl-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: monoterpenyl diphosphate + H2O = monoterpenol + diphosphate." [EC:3.1.7.3, MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN]
synonym: "bornyl diphosphate hydrolase activity" EXACT [EC:3.1.7.3]
synonym: "bornyl pyrophosphate hydrolase activity" EXACT [EC:3.1.7.3]
synonym: "monoterpenyl-diphosphate diphosphohydrolase activity" EXACT [EC:3.1.7.3]
synonym: "monoterpenyl-pyrophosphatase activity" EXACT []
xref: EC:3.1.7.3
xref: MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN
is_a: GO:0016794 ! diphosphoric monoester hydrolase activity

[Term]
id: GO:0050109
name: morphine 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+." [EC:1.1.1.218, MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "morphine:NAD(P)+ 6-oxidoreductase activity" EXACT [EC:1.1.1.218]
synonym: "naloxone reductase activity" EXACT [EC:1.1.1.218]
synonym: "reductase, naloxone" EXACT [EC:1.1.1.218]
xref: EC:1.1.1.218
xref: MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050110
name: mucinaminylserine mucinaminidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine." [EC:3.2.1.110, MetaCyc:MUCINAMINYLSERINE-MUCINAMINIDASE-RXN]
synonym: "D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine mucinaminohydrolase activity" EXACT [EC:3.2.1.110]
synonym: "endo-alpha-N-acetyl-D-galactosaminidase activity" EXACT [EC:3.2.1.110]
synonym: "endo-alpha-N-acetylgalactosaminidase" BROAD [EC:3.2.1.110]
xref: EC:3.2.1.110
xref: MetaCyc:3.2.1.110-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0050111
name: mycocerosate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + n methylmalonyl-CoA + 2n NADPH + 2n H+ = multi-methyl-branched acyl-CoA + n CoA + n CO2 + 2n NADP+." [EC:2.3.1.111, MetaCyc:MYCOCEROSATE-SYNTHASE-RXN]
synonym: "acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)" EXACT [EC:2.3.1.111]
synonym: "mycocerosic acid synthase activity" EXACT [EC:2.3.1.111]
xref: EC:2.3.1.111
xref: MetaCyc:MYCOCEROSATE-SYNTHASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050112
name: inositol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH." [EC:1.1.1.18, MetaCyc:MYO-INOSITOL-2-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "myo-inositol 2-dehydrogenase activity" EXACT []
xref: EC:1.1.1.18
xref: MetaCyc:MYO-INOSITOL-2-DEHYDROGENASE-RXN
is_a: GO:0004033 ! aldo-keto reductase activity

[Term]
id: GO:0050113
name: inositol oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O." [EC:1.13.99.1, MetaCyc:MYO-INOSITOL-OXYGENASE-RXN]
synonym: "meso-inositol oxygenase activity" EXACT [EC:1.13.99.1]
synonym: "MOO activity" EXACT [EC:1.13.99.1]
synonym: "myo-inositol oxygenase activity" EXACT []
synonym: "myo-inositol:oxygen oxidoreductase activity" EXACT [EC:1.13.99.1]
xref: EC:1.13.99.1
xref: MetaCyc:MYO-INOSITOL-OXYGENASE-RXN
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0050114
name: myo-inosose-2 dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3,5/4-trihydroxycyclohexa-1,2-dione + H2O." [EC:4.2.1.44, MetaCyc:MYO-INOSOSE-2-DEHYDRATASE-RXN]
synonym: "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming)" EXACT [EC:4.2.1.44]
synonym: "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase activity" EXACT [EC:4.2.1.44]
synonym: "inosose 2,3-dehydratase activity" EXACT [EC:4.2.1.44]
synonym: "ketoinositol dehydratase activity" EXACT [EC:4.2.1.44]
xref: EC:4.2.1.44
xref: MetaCyc:MYO-INOSOSE-2-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050115
name: myosin-light-chain-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate." [EC:3.1.3.53, MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN]
synonym: "[Myosin light-chain]-phosphatase activity" EXACT []
synonym: "myosin light chain kinase phosphatase activity" EXACT [EC:3.1.3.53]
synonym: "myosin light-chain kinase phosphatase activity" RELATED [EC:3.1.3.53]
synonym: "myosin-light-chain phosphatase activity" EXACT [EC:3.1.3.53]
synonym: "myosin-light-chain-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.53]
synonym: "protein phosphatase 2A" RELATED [EC:3.1.3.53]
xref: EC:3.1.3.53
xref: MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050116
name: N,N-dimethylformamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N-dimethylformamide + H2O = dimethylamine + formate." [EC:3.5.1.56, MetaCyc:NN-DIMETHYLFORMAMIDASE-RXN]
synonym: "dimethylformamidase activity" EXACT [EC:3.5.1.56]
synonym: "DMFase activity" EXACT [EC:3.5.1.56]
synonym: "N,N-dimethylformamide amidohydrolase activity" EXACT [EC:3.5.1.56]
xref: EC:3.5.1.56
xref: MetaCyc:NN-DIMETHYLFORMAMIDASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050117
name: N-acetyl-beta-alanine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-beta-alanine + H2O = acetate + beta-alanine." [EC:3.5.1.21, MetaCyc:N-ACETYL-BETA-ALANINE-DEACETYLASE-RXN]
synonym: "N-acetyl-beta-alanine amidohydrolase activity" EXACT [EC:3.5.1.21]
xref: EC:3.5.1.21
xref: MetaCyc:N-ACETYL-BETA-ALANINE-DEACETYLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0050118
name: N-acetyldiaminopimelate deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-LL2,6-diaminoheptanedioate + H2O = acetate + LL2,6-diaminoheptanedioate." [EC:3.5.1.47, MetaCyc:N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN]
subset: gosubset_prok
synonym: "6-N-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.47]
synonym: "N-acetyl-L-diaminopimelic acid deacylase activity" EXACT [EC:3.5.1.47]
synonym: "N-acetyl-LL-diaminopimelate deacylase activity" EXACT [EC:3.5.1.47]
synonym: "N6-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.47]
xref: EC:3.5.1.47
xref: MetaCyc:N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0050119
name: N-acetylglucosamine deacetylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H2O = D-glucosamine + acetate." [EC:3.5.1.33, MetaCyc:N-ACETYLGLUCOSAMINE-DEACETYLASE-RXN]
synonym: "acetylaminodeoxyglucose acetylhydrolase activity" EXACT [EC:3.5.1.33]
synonym: "N-acetyl-D-glucosamine amidohydrolase activity" EXACT [EC:3.5.1.33]
synonym: "N-acetyl-D-glucosaminyl N-deacetylase activity" EXACT [EC:3.5.1.33]
xref: EC:3.5.1.33
xref: MetaCyc:N-ACETYLGLUCOSAMINE-DEACETYLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
is_a: GO:0019213 ! deacetylase activity

[Term]
id: GO:0050120
name: N-acetylhexosamine 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD+ + N-acetyl-D-glucosamine = NADH + N-acetyl-D-glucosaminate." [EC:1.1.1.240, MetaCyc:N-ACETYLHEXOSAMINE-1-DEHYDROGENASE-RXN]
synonym: "N-acetyl-D-hexosamine dehydrogenase activity" EXACT [EC:1.1.1.240]
synonym: "N-acetyl-D-hexosamine:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.240]
synonym: "N-acetylhexosamine dehydrogenase activity" EXACT [EC:1.1.1.240]
xref: EC:1.1.1.240
xref: MetaCyc:N-ACETYLHEXOSAMINE-1-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050121
name: N-acylglucosamine 2-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine." [EC:5.1.3.8, MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN]
subset: gosubset_prok
synonym: "acylglucosamine 2-epimerase activity" EXACT [EC:5.1.3.8]
synonym: "GlcNAc 2-epimerase activity" EXACT [EC:5.1.3.8]
synonym: "N-acetyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.8]
synonym: "N-acetylglucosamine 2-epimerase activity" EXACT [EC:5.1.3.8]
synonym: "N-acyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.8]
xref: EC:5.1.3.8
xref: MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050122
name: N-acylhexosamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + O2 + N-acetyl-D-glucosamine = H2O2 + N-acetyl-D-glucosaminate." [EC:1.1.3.29, MetaCyc:N-ACYLHEXOSAMINE-OXIDASE-RXN]
synonym: "N-acyl-beta-D-hexosamine:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.29]
synonym: "N-acyl-D-hexosamine oxidase activity" EXACT [EC:1.1.3.29]
synonym: "N-acyl-D-hexosamine:oxygen 1-oxidoreductase activity" EXACT [EC:1.1.3.29]
xref: EC:1.1.3.29
xref: MetaCyc:N-ACYLHEXOSAMINE-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050123
name: N-acylmannosamine 1-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acyl-D-mannosamine + NAD+ = N-acyl-D-mannosaminolactone + NADH." [EC:1.1.1.233, MetaCyc:N-ACYLMANNOSAMINE-1-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "N-acetyl-D-mannosamine dehydrogenase activity" EXACT [EC:1.1.1.233]
synonym: "N-acyl-D-mannosamine dehydrogenase activity" EXACT [EC:1.1.1.233]
synonym: "N-acyl-D-mannosamine:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.233]
synonym: "N-acylmannosamine dehydrogenase activity" EXACT [EC:1.1.1.233]
xref: EC:1.1.1.233
xref: MetaCyc:N-ACYLMANNOSAMINE-1-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050124
name: N-acylneuraminate-9-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate." [EC:3.1.3.29, MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN]
subset: gosubset_prok
synonym: "acylneuraminate 9-phosphatase activity" EXACT [EC:3.1.3.29]
synonym: "N-acylneuraminate-9-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.29]
synonym: "N-acylneuraminic (sialic) acid 9-phosphatase activity" EXACT [EC:3.1.3.29]
synonym: "N-acylneuraminic acid 9-phosphate phosphatase activity" EXACT [EC:3.1.3.29]
xref: EC:3.1.3.29
xref: MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050125
name: N-benzyloxycarbonylglycine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-benzyloxycarbonylglycine + H2O = benzyl alcohol + CO2 + glycine." [EC:3.5.1.58, MetaCyc:N-BENZYLOXYCARBONYLGLYCINE-HYDROLASE-RXN]
synonym: "benzyloxycarbonylglycine hydrolase activity" EXACT [EC:3.5.1.58]
synonym: "N-benzyloxycarbonylglycine urethanehydrolase activity" EXACT [EC:3.5.1.58]
synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase activity" EXACT [EC:3.5.1.58]
synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase I" RELATED [EC:3.5.1.58]
synonym: "nalpha-carbobenzoxyamino acid amidohydrolase activity" EXACT [EC:3.5.1.58]
xref: EC:3.5.1.58
xref: MetaCyc:N-BENZYLOXYCARBONYLGLYCINE-HYDROLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050126
name: N-carbamoylputrescine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N-carbamoylputrescine = NH3 + CO2 + putrescine." [EC:3.5.1.53, MetaCyc:N-CARBAMOYLPUTRESCINE-AMIDASE-RXN]
synonym: "carbamoylputrescine hydrolase activity" EXACT [EC:3.5.1.53]
synonym: "N-carbamoylputrescine amidohydrolase activity" EXACT [EC:3.5.1.53]
synonym: "NCP" RELATED [EC:3.5.1.53]
xref: EC:3.5.1.53
xref: MetaCyc:N-CARBAMOYLPUTRESCINE-AMIDASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050127
name: N-carbamoylsarcosine amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-carbamoylsarcosine + H2O = sarcosine + CO2 + NH3." [EC:3.5.1.59, MetaCyc:N-CARBAMOYLSARCOSINE-AMIDASE-RXN]
subset: gosubset_prok
synonym: "carbamoylsarcosine amidase activity" EXACT [EC:3.5.1.59]
synonym: "CSHase activity" EXACT [EC:3.5.1.59]
synonym: "N-carbamoylsarcosine amidohydrolase activity" EXACT [EC:3.5.1.59]
xref: EC:3.5.1.59
xref: MetaCyc:N-CARBAMOYLSARCOSINE-AMIDASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050128
name: N-feruloylglycine deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-feruloylglycine + H2O = ferulate + glycine." [EC:3.5.1.71, MetaCyc:N-FERULOYLGLYCINE-DEACYLASE-RXN]
synonym: "N-feruloylglycine amidohydrolase activity" EXACT [EC:3.5.1.71]
synonym: "N-feruloylglycine hydrolase activity" EXACT [EC:3.5.1.71]
xref: EC:3.5.1.71
xref: MetaCyc:N-FERULOYLGLYCINE-DEACYLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050129
name: N-formylglutamate deformylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formyl-L-glutamate + H2O = formate + L-glutamate." [EC:3.5.1.68, MetaCyc:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN]
subset: gosubset_prok
synonym: "beta-citryl-L-glutamate amidase activity" EXACT [EC:3.5.1.68]
synonym: "beta-citryl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.68]
synonym: "beta-citryl-L-glutamate hydrolase activity" EXACT [EC:3.5.1.68]
synonym: "beta-citryl-L-glutamate-hydrolyzing enzyme" RELATED [EC:3.5.1.68]
synonym: "beta-citrylglutamate amidase activity" EXACT [EC:3.5.1.68]
synonym: "formylglutamate deformylase activity" EXACT [EC:3.5.1.68]
synonym: "N-formyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.68]
synonym: "N-formylglutamate hydrolase activity" EXACT [EC:3.5.1.68]
xref: EC:3.5.1.68
xref: MetaCyc:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050130
name: N-methyl-2-oxoglutaramate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylamine." [EC:3.5.1.36, MetaCyc:N-METHYL-2-OXOGLUTARAMATE-HYDROLASE-RXN]
synonym: "5-hydroxy-N-methylpyroglutamate synthase activity" EXACT [EC:3.5.1.36]
synonym: "N-methyl-2-oxoglutaramate methylamidohydrolase activity" EXACT [EC:3.5.1.36]
xref: EC:3.5.1.36
xref: MetaCyc:N-METHYL-2-OXOGLUTARAMATE-HYDROLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050131
name: N-methyl-L-amino-acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2." [EC:1.5.3.2, MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN]
synonym: "N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.2]
synonym: "N-methylamino acid oxidase activity" EXACT [EC:1.5.3.2]
xref: EC:1.5.3.2
xref: MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0050132
name: N-methylalanine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-methyl-L-alanine + H2O + NADP+ = pyruvate + methylamine + NADPH." [EC:1.4.1.17, MetaCyc:N-METHYLALANINE-DEHYDROGENASE-RXN]
synonym: "N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating)" EXACT [EC:1.4.1.17]
xref: EC:1.4.1.17
xref: MetaCyc:N-METHYLALANINE-DEHYDROGENASE-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050133
name: N6-hydroxylysine O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + N6-hydroxy-L-lysine = CoA + N6-acetyl-N6-hydroxy-L-lysine." [EC:2.3.1.102, MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA:6-N-hydroxy-L-lysine 6-acetyltransferase activity" EXACT [EC:2.3.1.102]
synonym: "acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase activity" EXACT [EC:2.3.1.102]
synonym: "N(6)-hydroxylysine acetylase activity" EXACT [EC:2.3.1.102]
synonym: "N6-hydroxylysine acetylase activity" EXACT [EC:2.3.1.102]
synonym: "N6-hydroxylysine:acetyl CoA N6-transacetylase activity" EXACT [EC:2.3.1.102]
xref: EC:2.3.1.102
xref: MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050134
name: N6-methyl-lysine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N6-methyl-L-lysine + H2O + O2 = L-lysine + formaldehyde + H2O2." [EC:1.5.3.4, MetaCyc:N6-METHYL-LYSINE-OXIDASE-RXN]
synonym: "6-N-methyl-L-lysine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.4]
synonym: "epsilon-alkyl-L-lysine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.4]
synonym: "epsilon-alkyllysinase activity" EXACT [EC:1.5.3.4]
synonym: "epsilon-N-methyllysine demethylase activity" EXACT [EC:1.5.3.4]
synonym: "N(6)-methyllysine oxidase activity" EXACT [EC:1.5.3.4]
synonym: "N6-methyl-L-lysine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.4]
synonym: "N6-methyllysine oxidase activity" EXACT [EC:1.5.3.4]
xref: EC:1.5.3.4
xref: MetaCyc:N6-METHYL-LYSINE-OXIDASE-RXN
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0050135
name: NAD(P)+ nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + H2O = ADPribose(P) + nicotinamide." [EC:3.2.2.6, MetaCyc:NADP+-NUCLEOSIDASE-RXN]
synonym: "NAD(P) nucleosidase activity" EXACT []
synonym: "NAD(P)(+) nucleosidase activity" EXACT []
synonym: "NAD(P)+ glycohydrolase activity" EXACT [EC:3.2.2.6]
synonym: "NAD(P)ase activity" EXACT [EC:3.2.2.6]
synonym: "nicotinamide adenine dinucleotide (phosphate) glycohydrolase activity" EXACT [EC:3.2.2.6]
synonym: "nicotinamide adenine dinucleotide (phosphate) nucleosidase activity" EXACT [EC:3.2.2.6]
synonym: "triphosphopyridine nucleotidase activity" EXACT [EC:3.2.2.6]
xref: EC:3.2.2.6
xref: MetaCyc:NADP+-NUCLEOSIDASE-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0050136
name: NADH dehydrogenase (quinone) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol." [EC:1.6.99.5, GOC:mah, MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN]
subset: gosubset_prok
synonym: "D-diaphorase activity" EXACT [EC:1.6.99.5]
synonym: "DPNH-menadione reductase activity" EXACT [EC:1.6.99.5]
synonym: "NADH-quinone oxidoreductase activity" EXACT [EC:1.6.99.5]
synonym: "NADH:(quinone-acceptor) oxidoreductase activity" EXACT [EC:1.6.99.5]
synonym: "reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase activity" EXACT [EC:1.6.99.5]
xref: EC:1.6.99.5
xref: MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN
is_a: GO:0003954 ! NADH dehydrogenase activity
is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor

[Term]
id: GO:0050137
name: NADPH peroxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADPH + H2O2 = NADP+ + 2 H2O." [EC:1.11.1.2, MetaCyc:NADPH-PEROXIDASE-RXN]
synonym: "NADP peroxidase activity" EXACT [EC:1.11.1.2]
synonym: "NADPH:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.2]
synonym: "nicotinamide adenine dinucleotide phosphate peroxidase activity" EXACT [EC:1.11.1.2]
synonym: "TPN peroxidase activity" EXACT [EC:1.11.1.2]
synonym: "TPNH peroxidase activity" EXACT [EC:1.11.1.2]
synonym: "triphosphopyridine nucleotide peroxidase activity" EXACT [EC:1.11.1.2]
xref: EC:1.11.1.2
xref: MetaCyc:NADPH-PEROXIDASE-RXN
is_a: GO:0004601 ! peroxidase activity

[Term]
id: GO:0050138
name: nicotinate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotinate + H2O + NADP+ = 6-hydroxynicotinate + NADPH." [EC:1.17.1.5, MetaCyc:NICOTINATE-DEHYDROGENASE-RXN]
synonym: "nicotinate hydroxylase activity" EXACT [EC:1.17.1.5]
synonym: "nicotinate:NADP+ 6-oxidoreductase (hydroxylating)" EXACT [EC:1.17.1.5]
synonym: "nicotinic acid hydroxylase activity" EXACT [EC:1.17.1.5]
xref: EC:1.17.1.5
xref: MetaCyc:NICOTINATE-DEHYDROGENASE-RXN
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0050139
name: nicotinate glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + nicotinate = UDP + N-glucosylnicotinate." [EC:2.4.1.196, MetaCyc:NICOTINATE-GLUCOSYLTRANSFERASE-RXN]
synonym: "UDP-glucose:nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196]
synonym: "UDP-glucose:nicotinic acid-N-glucosyltransferase activity" EXACT [EC:2.4.1.196]
synonym: "UDPglucose:nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196]
synonym: "uridine diphosphoglucose-nicotinate N-glucosyltransferase activity" EXACT [EC:2.4.1.196]
xref: EC:2.4.1.196
xref: MetaCyc:NICOTINATE-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050140
name: nitrate reductase (cytochrome) activity
namespace: molecular_function
def: "Catalysis of the reaction: ferrocytochrome + NO3- (nitrate) = ferricytochrome + NO2- (nitrite)." [EC:1.9.6.1, MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN]
synonym: "benzyl viologen-nitrate reductase activity" EXACT [EC:1.9.6.1]
synonym: "ferrocytochrome:nitrate oxidoreductase activity" EXACT [EC:1.9.6.1]
xref: EC:1.9.6.1
xref: MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN
is_a: GO:0016677 ! oxidoreductase activity, acting on heme group of donors, nitrogenous group as acceptor

[Term]
id: GO:0050141
name: nitroethane oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + NO2(-) (nitrite) + H2O2." [EC:1.7.3.1, MetaCyc:NITROETHANE-OXIDASE-RXN]
synonym: "NAO activity" EXACT [EC:1.7.3.1]
synonym: "nitroalkane:oxygen oxidoreductase activity" EXACT [EC:1.7.3.1]
synonym: "Nitroethane oxidase activity" EXACT [EC:1.7.3.1]
synonym: "nitroethane reductase activity" EXACT [EC:1.7.3.1]
synonym: "nitroethane:oxygen oxidoreductase activity" EXACT [EC:1.7.3.1]
xref: EC:1.7.3.1
xref: MetaCyc:NITROETHANE-OXIDASE-RXN
is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor

[Term]
id: GO:0050142
name: nitrogenase (flavodoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate." [EC:1.19.6.1, MetaCyc:NITROGENASE-FLAVODOXIN-RXN]
subset: gosubset_prok
synonym: "reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing)" EXACT [EC:1.19.6.1]
xref: EC:1.19.6.1
xref: MetaCyc:NITROGENASE-FLAVODOXIN-RXN
is_a: GO:0016738 ! oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor

[Term]
id: GO:0050143
name: nocardicin-A epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: isonocardicin A = nocardicin A." [EC:5.1.1.14, MetaCyc:NOCARDICIN-A-EPIMERASE-RXN]
synonym: "isonocardicin A epimerase activity" EXACT [EC:5.1.1.14]
xref: EC:5.1.1.14
xref: MetaCyc:NOCARDICIN-A-EPIMERASE-RXN
is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives

[Term]
id: GO:0050144
name: nucleoside deoxyribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1." [EC:2.4.2.6, MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN]
subset: gosubset_prok
synonym: "deoxyribose transferase activity" EXACT [EC:2.4.2.6]
synonym: "nucleoside deoxyribosyltransferase I (purine nucleoside:purine deoxyribosyltransferase: strictly specific for transfer between purine bases)" RELATED [EC:2.4.2.6]
synonym: "nucleoside deoxyribosyltransferase II [purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase]" RELATED [EC:2.4.2.6]
synonym: "nucleoside trans-N-deoxyribosylase activity" EXACT [EC:2.4.2.6]
synonym: "nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.6]
synonym: "purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase activity" EXACT [EC:2.4.2.6]
synonym: "trans-deoxyribosylase activity" EXACT [EC:2.4.2.6]
synonym: "trans-N-deoxyribosylase activity" EXACT [EC:2.4.2.6]
synonym: "trans-N-glycosidase activity" EXACT [EC:2.4.2.6]
xref: EC:2.4.2.6
xref: MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0050145
name: nucleoside phosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nucleoside phosphate = ADP + nucleoside diphosphate." [EC:2.7.4.4, MetaCyc:NUCLEOSIDE-PHOSPHATE-KINASE-RXN]
synonym: "ATP:nucleoside-phosphate phosphotransferase activity" EXACT [EC:2.7.4.4]
synonym: "NMP-kinase activity" EXACT [EC:2.7.4.4]
synonym: "nucleoside monophosphate kinase activity" EXACT [GOC:dph, GOC:tb]
synonym: "nucleoside-phosphate kinase activity" EXACT []
xref: EC:2.7.4.4
xref: MetaCyc:NUCLEOSIDE-PHOSPHATE-KINASE-RXN
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor
is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity

[Term]
id: GO:0050146
name: nucleoside phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate." [EC:2.7.1.77, MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN]
synonym: "nonspecific nucleoside phosphotransferase activity" EXACT [EC:2.7.1.77]
synonym: "nucleotide:2'-nucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77]
synonym: "nucleotide:3'-deoxynucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77]
synonym: "nucleotide:nucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.77]
xref: EC:2.7.1.77
xref: MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity

[Term]
id: GO:0050147
name: nucleoside ribosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1." [EC:2.4.2.5, MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN]
synonym: "nucleoside N-ribosyltransferase activity" EXACT [EC:2.4.2.5]
synonym: "nucleoside:purine(pyrimidine) D-ribosyltransferase activity" EXACT [EC:2.4.2.5]
xref: EC:2.4.2.5
xref: MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0050148
name: nucleotide diphosphokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate." [EC:2.7.6.4, MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN]
synonym: "ATP nucleotide 3'-pyrophosphokinase activity" EXACT [EC:2.7.6.4]
synonym: "ATP:nucleoside-5'-phosphate diphosphotransferase activity" EXACT [EC:2.7.6.4]
synonym: "ATP:nucleotide pyrophosphotransferase activity" EXACT [EC:2.7.6.4]
synonym: "nucleotide 3'-pyrophosphokinase activity" EXACT [EC:2.7.6.4]
synonym: "nucleotide pyrophosphokinase activity" EXACT []
xref: EC:2.7.6.4
xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN
is_a: GO:0016778 ! diphosphotransferase activity

[Term]
id: GO:0050149
name: o-aminophenol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O." [EC:1.10.3.4, MetaCyc:O-AMINOPHENOL-OXIDASE-RXN]
synonym: "2-aminophenol:O2 oxidoreductase activity" EXACT [EC:1.10.3.4]
synonym: "2-aminophenol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.4]
synonym: "GriF" RELATED [EC:1.10.3.4]
synonym: "isophenoxazine synthase activity" EXACT [EC:1.10.3.4]
synonym: "o-aminophenol:O2 oxidoreductase activity" EXACT [EC:1.10.3.4]
xref: EC:1.10.3.4
xref: MetaCyc:O-AMINOPHENOL-OXIDASE-RXN
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0050150
name: o-pyrocatechuate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,3-dihydroxybenzoate = catechol + CO2." [EC:4.1.1.46, MetaCyc:O-PYROCATECHUATE-DECARBOXYLASE-RXN]
synonym: "2,3-DHBA decarboxylase activity" EXACT [EC:4.1.1.46]
synonym: "2,3-dihydroxybenzoate carboxy-lyase (catechol-forming)" EXACT [EC:4.1.1.46]
synonym: "2,3-dihydroxybenzoate carboxy-lyase activity" EXACT [EC:4.1.1.46]
synonym: "2,3-dihydroxybenzoic acid decarboxylase activity" EXACT [EC:4.1.1.46]
xref: EC:4.1.1.46
xref: MetaCyc:O-PYROCATECHUATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050151
name: oleate hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-10-hydroxystearate = oleate + H2O." [EC:4.2.1.53, MetaCyc:OLEATE-HYDRATASE-RXN]
synonym: "(R)-10-hydroxystearate 10-hydro-lyase (oleate-forming)" EXACT [EC:4.2.1.53]
synonym: "(R)-10-hydroxystearate 10-hydro-lyase activity" EXACT [EC:4.2.1.53]
xref: EC:4.2.1.53
xref: MetaCyc:OLEATE-HYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050152
name: omega-amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3." [EC:3.5.1.3, MetaCyc:OMEGA-AMIDASE-RXN]
synonym: "alpha-keto acid-omega-amidase activity" EXACT [EC:3.5.1.3]
synonym: "omega-amidodicarboxylate amidohydrolase activity" EXACT [EC:3.5.1.3]
synonym: "w-amidase activity" EXACT []
xref: EC:3.5.1.3
xref: MetaCyc:OMEGA-AMIDASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050153
name: omega-hydroxydecanoate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-hydroxydecanoate + NAD+ = 10-oxodecanoate + NADH." [EC:1.1.1.66, MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN]
synonym: "10-hydroxydecanoate:NAD+ 10-oxidoreductase activity" EXACT [EC:1.1.1.66]
synonym: "w-hydroxydecanoate dehydrogenase activity" EXACT []
xref: EC:1.1.1.66
xref: MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050154
name: opheline kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = ADP + N'-phosphoguanidinoethyl methylphosphate." [EC:2.7.3.7, MetaCyc:OPHELINE-KINASE-RXN]
synonym: "ATP:guanidinoethyl-methyl-phosphate phosphotransferase activity" EXACT [EC:2.7.3.7]
xref: EC:2.7.3.7
xref: MetaCyc:OPHELINE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0050155
name: ornithine(lysine) transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate." [EC:2.6.1.68, MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN]
synonym: "L-ornithine(L-lysine):2-oxoglutarate-aminotransferase activity" EXACT [EC:2.6.1.68]
synonym: "L-ornithine:2-oxoglutarate-aminotransferase activity" EXACT [EC:2.6.1.68]
synonym: "lysine/ornithine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.68]
synonym: "ornithine(lysine) aminotransferase activity" EXACT []
xref: EC:2.6.1.68
xref: MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0050156
name: ornithine N-benzoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 benzoyl-CoA + L-ornithine = 2 CoA + N2,N5-dibenzoyl-L-ornithine." [EC:2.3.1.127, MetaCyc:ORNITHINE-N-BENZOYLTRANSFERASE-RXN]
synonym: "benzoyl-CoA:L-ornithine N-benzoyltransferase activity" EXACT [EC:2.3.1.127]
synonym: "ornithine N-acyltransferase activity" EXACT [EC:2.3.1.127]
xref: EC:2.3.1.127
xref: MetaCyc:ORNITHINE-N-BENZOYLTRANSFERASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050157
name: ornithine racemase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-ornithine = D-ornithine." [EC:5.1.1.12, MetaCyc:ORNITHINE-RACEMASE-RXN]
subset: gosubset_prok
xref: EC:5.1.1.12
xref: MetaCyc:ORNITHINE-RACEMASE-RXN
is_a: GO:0047661 ! amino-acid racemase activity

[Term]
id: GO:0050158
name: orotate reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-dihydroorotate + NADP+ = orotate + NADPH." [EC:1.3.1.15, MetaCyc:OROTATE-REDUCTASE-NADPH-RXN]
synonym: "(S)-dihydroorotate:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.15]
synonym: "dihydro-orotic dehydrogenase activity" EXACT [EC:1.3.1.15]
synonym: "L-5,6-dihydro-orotate:NAD oxidoreductase activity" EXACT [EC:1.3.1.15]
synonym: "orotate reductase activity" EXACT [EC:1.3.1.15]
xref: EC:1.3.1.15
xref: MetaCyc:OROTATE-REDUCTASE-NADPH-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050159
name: orsellinate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4-dihydroxy-6-methylbenzoate = orcinol + CO2." [EC:4.1.1.58, MetaCyc:ORSELLINATE-DECARBOXYLASE-RXN]
synonym: "orsellinate carboxy-lyase (orcinol-forming)" EXACT [EC:4.1.1.58]
synonym: "orsellinate carboxy-lyase activity" EXACT [EC:4.1.1.58]
xref: EC:4.1.1.58
xref: MetaCyc:ORSELLINATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050160
name: orsellinate-depside hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: orsellinate depside + H2O = 2 orsellinate." [EC:3.1.1.40, MetaCyc:ORSELLINATE-DEPSIDE-HYDROLASE-RXN]
synonym: "lecanorate hydrolase activity" EXACT [EC:3.1.1.40]
xref: EC:3.1.1.40
xref: MetaCyc:ORSELLINATE-DEPSIDE-HYDROLASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050161
name: oxalate CoA-transferase activity
namespace: molecular_function
def: "Catalysis of the reaction: succinyl-CoA + oxalate = succinate + oxalyl-CoA." [EC:2.8.3.2, MetaCyc:OXALATE-COA-TRANSFERASE-RXN]
synonym: "oxalate coenzyme A-transferase activity" EXACT [EC:2.8.3.2]
synonym: "succinyl-beta-ketoacyl-CoA transferase activity" EXACT [EC:2.8.3.2]
synonym: "succinyl-CoA:oxalate CoA-transferase activity" EXACT [EC:2.8.3.2]
xref: EC:2.8.3.2
xref: MetaCyc:OXALATE-COA-TRANSFERASE-RXN
is_a: GO:0008410 ! CoA-transferase activity

[Term]
id: GO:0050162
name: oxalate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: oxalate + O2 = 2 CO2 + H2O2." [EC:1.2.3.4, MetaCyc:OXALATE-OXIDASE-RXN]
synonym: "aero-oxalo dehydrogenase activity" EXACT [EC:1.2.3.4]
synonym: "oxalate:oxygen oxidoreductase activity" EXACT [EC:1.2.3.4]
synonym: "oxalic acid oxidase activity" EXACT [EC:1.2.3.4]
xref: EC:1.2.3.4
xref: MetaCyc:OXALATE-OXIDASE-RXN
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0050163
name: oxaloacetate tautomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: keto-oxaloacetate = enol-oxaloacetate." [EC:5.3.2.2, MetaCyc:OXALOACETATE-TAUTOMERASE-RXN]
synonym: "oxalacetic keto-enol isomerase activity" EXACT [EC:5.3.2.2]
synonym: "oxaloacetate keto-enol tautomerase activity" EXACT [EC:5.3.2.2]
synonym: "oxaloacetate keto-enol-isomerase activity" EXACT [EC:5.3.2.2]
xref: EC:5.3.2.2
xref: MetaCyc:OXALOACETATE-TAUTOMERASE-RXN
is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups

[Term]
id: GO:0050164
name: oxoglutarate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NADP+ = succinyl-CoA + CO2 + NADPH." [EC:1.2.1.52, MetaCyc:OXOGLUTARATE-DEHYDROGENASE-NADP+-RXN]
synonym: "2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating)" EXACT [EC:1.2.1.52]
xref: EC:1.2.1.52
xref: MetaCyc:OXOGLUTARATE-DEHYDROGENASE-NADP+-RXN
is_a: GO:0034601 ! oxoglutarate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0050165
name: pantetheine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate." [EC:2.7.1.34, MetaCyc:PANTETHEINE-KINASE-RXN]
synonym: "ATP:pantetheine 4'-phosphotransferase activity" EXACT [EC:2.7.1.34]
synonym: "pantetheine kinase (phosphorylating)" EXACT [EC:2.7.1.34]
xref: EC:2.7.1.34
xref: MetaCyc:PANTETHEINE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050166
name: pantoate 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-pantoate + NAD+ = (R)-4-dehydropantoate + NADH." [EC:1.1.1.106, MetaCyc:PANTOATE-4-DEHYDROGENASE-RXN]
synonym: "(R)-pantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.106]
synonym: "D-pantoate:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.106]
synonym: "panthothenase activity" EXACT [EC:1.1.1.106]
synonym: "pantoate dehydrogenase activity" EXACT [EC:1.1.1.106]
xref: EC:1.1.1.106
xref: MetaCyc:PANTOATE-4-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050167
name: pantothenoylcysteine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine = pantetheine + CO2." [EC:4.1.1.30, MetaCyc:PANTOTHENOYLCYSTEINE-DECARBOXYLASE-RXN]
synonym: "N-((R)-pantothenoyl)-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.30]
synonym: "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase (pantetheine-forming)" EXACT [EC:4.1.1.30]
synonym: "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.30]
synonym: "pantothenylcysteine decarboxylase activity" EXACT [EC:4.1.1.30]
xref: EC:4.1.1.30
xref: MetaCyc:PANTOTHENOYLCYSTEINE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050168
name: pentanamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: pentanamide + H2O = pentanoate + NH3." [EC:3.5.1.50, MetaCyc:PENTANAMIDASE-RXN]
synonym: "pentanamide amidohydrolase activity" EXACT [EC:3.5.1.50]
synonym: "valeramidase activity" EXACT [EC:3.5.1.50]
xref: EC:3.5.1.50
xref: MetaCyc:PENTANAMIDASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050169
name: peptide-tryptophan 2,3-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: peptide tryptophan + O2 = peptide formylkynurenine." [EC:1.13.11.26, MetaCyc:PEPTIDE-TRYPTOPHAN-23-DIOXYGENASE-RXN]
synonym: "peptide-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.26]
synonym: "peptidyltryptophan 2,3-dioxygenase activity" EXACT [EC:1.13.11.26]
synonym: "pyrrolooxygenase activity" EXACT [EC:1.13.11.26]
synonym: "tryptophan pyrrolooxygenase activity" EXACT [EC:1.13.11.26]
xref: EC:1.13.11.26
xref: MetaCyc:PEPTIDE-TRYPTOPHAN-23-DIOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050170
name: peptidyl-glutaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3." [EC:3.5.1.43, MetaCyc:PEPTIDYL-GLUTAMINASE-RXN]
synonym: "peptideglutaminase activity" EXACT [EC:3.5.1.43]
synonym: "peptidoglutaminase activity" EXACT [EC:3.5.1.43]
synonym: "peptidoglutaminase I activity" NARROW [EC:3.5.1.43]
synonym: "peptidyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.43]
xref: EC:3.5.1.43
xref: MetaCyc:PEPTIDYL-GLUTAMINASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050171
name: phenol beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside." [EC:2.4.1.35, MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "phenol b-glucosyltransferase activity" EXACT []
synonym: "phenol-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35]
synonym: "UDP glucosyltransferase activity" EXACT [EC:2.4.1.35]
synonym: "UDP-glucose glucosyltransferase activity" EXACT [EC:2.4.1.35]
synonym: "UDP-glucose:phenol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35]
synonym: "UDPglucose:phenol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.35]
synonym: "UDPglucosyltransferase activity" EXACT [EC:2.4.1.35]
synonym: "uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.35]
xref: EC:2.4.1.35
xref: MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050172
name: phenylalanine 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + O2 = 2-phenylacetamide + CO2 + H2O." [EC:1.13.12.9, MetaCyc:PHENYLALANINE-2-MONOOXYGENASE-RXN]
subset: gosubset_prok
synonym: "L-phenylalanine oxidase (deaminating and decarboxylating)" EXACT [EC:1.13.12.9]
synonym: "l-phenylalanine oxidase (deaminating and decarboxylating) activity" EXACT [EC:1.13.12.9]
synonym: "L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.9]
synonym: "phenylalanine (deaminating, decarboxylating) oxidase activity" EXACT [EC:1.13.12.9]
synonym: "phenylalanine (deaminating, decarboxylating)oxidase activity" EXACT [EC:1.13.12.9]
xref: EC:1.13.12.9
xref: MetaCyc:PHENYLALANINE-2-MONOOXYGENASE-RXN
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0050173
name: phenylalanine adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-phenylalanine = diphosphate + N-adenylyl-L-phenylalanine." [EC:2.7.7.54, MetaCyc:PHENYLALANINE-ADENYLYLTRANSFERASE-RXN]
synonym: "ATP:L-phenylalanine adenylyltransferase activity" EXACT [EC:2.7.7.54]
synonym: "ATP:phenylalanine adenylyltransferase activity" EXACT []
synonym: "L-phenylalanine adenylyltransferase activity" EXACT [EC:2.7.7.54]
xref: EC:2.7.7.54
xref: MetaCyc:PHENYLALANINE-ADENYLYLTRANSFERASE-RXN
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0050174
name: phenylalanine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2." [EC:4.1.1.53, MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN]
synonym: "aromatic L-amino acid decarboxylase activity" EXACT [EC:4.1.1.53]
synonym: "L-phenylalanine carboxy-lyase (phenylethylamine-forming)" EXACT [EC:4.1.1.53]
synonym: "L-phenylalanine carboxy-lyase activity" EXACT [EC:4.1.1.53]
synonym: "L-phenylalanine decarboxylase activity" EXACT [EC:4.1.1.53]
xref: EC:4.1.1.53
xref: MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050175
name: phenylalanine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH." [EC:1.4.1.20, MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "L-phenylalanine dehydrogenase activity" EXACT [EC:1.4.1.20]
synonym: "L-phenylalanine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.20]
synonym: "PHD" RELATED [EC:1.4.1.20]
synonym: "PheDH activity" EXACT [EC:1.4.1.20]
xref: EC:1.4.1.20
xref: MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050176
name: phenylalanine N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + L-phenylalanine = CoA + N-acetyl-L-phenylalanine." [EC:2.3.1.53, MetaCyc:PHENYLALANINE-N-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA-L-phenylalanine alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.53]
synonym: "acetyl-CoA:L-phenylalanine N-acetyltransferase activity" EXACT [EC:2.3.1.53]
xref: EC:2.3.1.53
xref: MetaCyc:PHENYLALANINE-N-ACETYLTRANSFERASE-RXN
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0050177
name: phenylpyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2." [EC:4.1.1.43, MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN]
synonym: "phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)" EXACT [EC:4.1.1.43]
synonym: "phenylpyruvate carboxy-lyase activity" EXACT [EC:4.1.1.43]
xref: EC:4.1.1.43
xref: MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050178
name: phenylpyruvate tautomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate." [EC:5.3.2.1, MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN]
subset: gosubset_prok
synonym: "phenylpyruvate keto--enol tautomerase activity" EXACT [EC:5.3.2.1]
synonym: "phenylpyruvate keto-enol-isomerase activity" EXACT [EC:5.3.2.1]
synonym: "phenylpyruvic keto--enol isomerase activity" EXACT [EC:5.3.2.1]
xref: EC:5.3.2.1
xref: MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN
is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups

[Term]
id: GO:0050179
name: phenylserine aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-threo-3-phenylserine = glycine + benzaldehyde." [EC:4.1.2.26, MetaCyc:PHENYLSERINE-ALDOLASE-RXN]
synonym: "L-threo-3-phenylserine benzaldehyde-lyase (glycine-forming)" EXACT [EC:4.1.2.26]
synonym: "L-threo-3-phenylserine benzaldehyde-lyase activity" EXACT [EC:4.1.2.26]
xref: EC:4.1.2.26
xref: MetaCyc:PHENYLSERINE-ALDOLASE-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050180
name: phloretin hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: phloretin + H2O = phloretate + phloroglucinol." [EC:3.7.1.4, MetaCyc:PHLORETIN-HYDROLASE-RXN]
synonym: "2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase activity" EXACT [EC:3.7.1.4]
synonym: "lactase-phlorizin hydrolase" BROAD [EC:3.7.1.4]
xref: EC:3.7.1.4
xref: MetaCyc:PHLORETIN-HYDROLASE-RXN
is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

[Term]
id: GO:0050181
name: phorbol-diester hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: phorbol 12,13-dibutanoate + H2O = phorbol 13-butanoate + butanoate." [EC:3.1.1.51, MetaCyc:PHORBOL-DIESTER-HYDROLASE-RXN]
synonym: "12,13-diacylphorbate 12-acylhydrolase activity" EXACT [EC:3.1.1.51]
synonym: "diacylphorbate 12-hydrolase activity" EXACT [EC:3.1.1.51]
synonym: "PDEH" RELATED [EC:3.1.1.51]
synonym: "phorbol-12,13-diester 12-ester hydrolase activity" EXACT [EC:3.1.1.51]
xref: EC:3.1.1.51
xref: MetaCyc:PHORBOL-DIESTER-HYDROLASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050182
name: phosphate butyryltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanoyl-CoA + phosphate = CoA + butanoylphosphate." [EC:2.3.1.19, MetaCyc:PHOSPHATE-BUTYRYLTRANSFERASE-RXN]
subset: gosubset_prok
synonym: "butanoyl-CoA:phosphate butanoyltransferase activity" EXACT [EC:2.3.1.19]
synonym: "phosphotransbutyrylase activity" EXACT [EC:2.3.1.19]
xref: EC:2.3.1.19
xref: MetaCyc:PHOSPHATE-BUTYRYLTRANSFERASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050183
name: phosphatidylcholine 12-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NADH + O2 = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + NAD+ + H2O." [EC:1.14.13.26, MetaCyc:PHOSPHATIDYLCHOLINE-12-MONOOXYGENASE-RXN]
synonym: "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,NADH:oxygen oxidoreductase (12-hydroxylating)" EXACT [EC:1.14.13.26]
synonym: "oleate D12-hydroxylase activity" EXACT []
synonym: "oleate Delta(12)-hydroxylase activity" EXACT [EC:1.14.13.26]
synonym: "oleate delta12-hydroxylase activity" EXACT [EC:1.14.13.26]
synonym: "oleate delta12-monooxygenase activity" EXACT [EC:1.14.13.26]
synonym: "ricinoleic acid synthase activity" EXACT [EC:1.14.13.26]
xref: EC:1.14.13.26
xref: MetaCyc:PHOSPHATIDYLCHOLINE-12-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050184
name: phosphatidylcholine desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD+ = 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + NADH." [EC:1.3.1.35, MetaCyc:PHOSPHATIDYLCHOLINE-DESATURASE-RXN]
synonym: "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+ delta12-oxidoreductase activity" EXACT [EC:1.3.1.35]
synonym: "linoleate synthase activity" EXACT [EC:1.3.1.35]
synonym: "oleate desaturase activity" EXACT [EC:1.3.1.35]
synonym: "oleoyl-CoA desaturase activity" EXACT [EC:1.3.1.35]
synonym: "oleoylphosphatidylcholine desaturase activity" EXACT [EC:1.3.1.35]
xref: EC:1.3.1.35
xref: MetaCyc:PHOSPHATIDYLCHOLINE-DESATURASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050185
name: phosphatidylinositol deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-phosphatidyl-D-myo-inositol + H2O = 1-acylglycerophosphoinositol + a carboxylate." [EC:3.1.1.52, MetaCyc:PHOSPHATIDYLINOSITOL-DEACYLASE-RXN]
synonym: "1-phosphatidyl-D-myo-inositol 2-acylhydrolase activity" EXACT [EC:3.1.1.52]
synonym: "phosphatidylinositol phospholipase A2 activity" EXACT [EC:3.1.1.52]
xref: EC:3.1.1.52
xref: MetaCyc:PHOSPHATIDYLINOSITOL-DEACYLASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050186
name: phosphoadenylylsulfatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + SO4(2-) (sulfate)." [EC:3.6.2.2, MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN]
synonym: "3'-phosphoadenylylsulfate sulfohydrolase activity" EXACT [EC:3.6.2.2]
synonym: "3-phosphoadenosine 5-phosphosulfate sulfatase activity" EXACT [EC:3.6.2.2]
synonym: "3-phosphoadenylyl sulfatase activity" EXACT [EC:3.6.2.2]
synonym: "PAPS sulfatase activity" EXACT [EC:3.6.2.2]
synonym: "phosphoadenylylsulphatase activity" EXACT []
xref: EC:3.6.2.2
xref: MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN
is_a: GO:0016819 ! hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides

[Term]
id: GO:0050187
name: phosphoamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-phosphocreatine + H2O = creatine + phosphate." [EC:3.9.1.1, MetaCyc:PHOSPHOAMIDASE-RXN]
synonym: "creatine phosphatase activity" EXACT [EC:3.9.1.1]
synonym: "phosphamide hydrolase activity" EXACT [EC:3.9.1.1]
xref: EC:3.9.1.1
xref: MetaCyc:PHOSPHOAMIDASE-RXN
is_a: GO:0016825 ! hydrolase activity, acting on acid phosphorus-nitrogen bonds

[Term]
id: GO:0050188
name: phosphoenolpyruvate mutase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate." [EC:5.4.2.9, MetaCyc:PHOSPHOENOLPYRUVATE-MUTASE-RXN]
subset: gosubset_prok
synonym: "PEP mutase activity" EXACT [EC:5.4.2.9]
synonym: "PEP phosphomutase activity" EXACT [EC:5.4.2.9]
synonym: "PEPPM" RELATED [EC:5.4.2.9]
synonym: "phosphoenolpyruvate 2,3-phosphonomutase activity" EXACT [EC:5.4.2.9]
synonym: "phosphoenolpyruvate phosphomutase activity" EXACT [EC:5.4.2.9]
synonym: "phosphoenolpyruvate-phosphonopyruvate phosphomutase activity" EXACT [EC:5.4.2.9]
xref: EC:5.4.2.9
xref: MetaCyc:PHOSPHOENOLPYRUVATE-MUTASE-RXN
is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases

[Term]
id: GO:0050189
name: phosphoenolpyruvate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoenolpyruvate + H2O = pyruvate + phosphate." [EC:3.1.3.60, MetaCyc:PHOSPHOENOLPYRUVATE-PHOSPHATASE-RXN]
synonym: "PEP phosphatase activity" EXACT [EC:3.1.3.60]
synonym: "phosphoenolpyruvate phosphohydrolase activity" EXACT [EC:3.1.3.60]
xref: EC:3.1.3.60
xref: MetaCyc:PHOSPHOENOLPYRUVATE-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050190
name: phosphoglucokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-glucose 1-phosphate = ADP + D-glucose 1,6-bisphosphate." [EC:2.7.1.10, MetaCyc:PHOSPHOGLUCOKINASE-RXN]
synonym: "ATP:alpha-D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.10]
synonym: "ATP:D-glucose-1-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.10]
synonym: "glucose-phosphate kinase activity" EXACT [EC:2.7.1.10]
synonym: "phosphoglucokinase (phosphorylating)" EXACT [EC:2.7.1.10]
xref: EC:2.7.1.10
xref: MetaCyc:PHOSPHOGLUCOKINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050191
name: phosphoglycerate kinase (GTP) activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 3-phospho-D-glycerate = GDP + 3-phospho-D-glyceroyl phosphate." [EC:2.7.2.10, MetaCyc:PHOSPHOGLYCERATE-KINASE-GTP-RXN]
synonym: "GTP:3-phospho-D-glycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.10]
xref: EC:2.7.2.10
xref: MetaCyc:PHOSPHOGLYCERATE-KINASE-GTP-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor

[Term]
id: GO:0050192
name: phosphoglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glycerate 2-phosphate + H2O = D-glycerate + phosphate." [EC:3.1.3.20, MetaCyc:PHOSPHOGLYCERATE-PHOSPHATASE-RXN]
synonym: "D-2-phosphoglycerate phosphatase activity" EXACT [EC:3.1.3.20]
synonym: "D-glycerate-2-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.20]
synonym: "glycerophosphate phosphatase activity" EXACT [EC:3.1.3.20]
xref: EC:3.1.3.20
xref: MetaCyc:PHOSPHOGLYCERATE-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050193
name: phosphoketolase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O." [EC:4.1.2.9, MetaCyc:PHOSPHOKETOLASE-RXN]
subset: gosubset_prok
synonym: "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)" EXACT [EC:4.1.2.9]
synonym: "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (phosphate-acetylating) activity" EXACT [EC:4.1.2.9]
synonym: "xylulose-5-phosphate phosphoketolase activity" EXACT [EC:4.1.2.9]
xref: EC:4.1.2.9
xref: MetaCyc:PHOSPHOKETOLASE-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050194
name: phosphonoacetaldehyde hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphonoacetaldehyde + H2O = acetaldehyde + phosphate." [EC:3.11.1.1, MetaCyc:PHOSPHONOACETALDEHYDE-HYDROLASE-RXN]
subset: gosubset_prok
synonym: "2-oxoethylphosphonate phosphonohydrolase activity" EXACT [EC:3.11.1.1]
synonym: "2-phosphonoacetylaldehyde phosphonohydrolase activity" EXACT [EC:3.11.1.1]
synonym: "phosphonatase activity" EXACT [EC:3.11.1.1]
synonym: "phosphonoacetylaldehyde phosphonohydrolase activity" EXACT [EC:3.11.1.1]
xref: EC:3.11.1.1
xref: MetaCyc:PHOSPHONOACETALDEHYDE-HYDROLASE-RXN
is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds

[Term]
id: GO:0050195
name: phosphoribokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-ribose 5-phosphate = ADP + D-ribose 1,5-bisphosphate." [EC:2.7.1.18, MetaCyc:PHOSPHORIBOKINASE-RXN]
synonym: "ATP:D-ribose-5-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.18]
synonym: "phosphoribokinase (phosphorylating)" EXACT [EC:2.7.1.18]
xref: EC:2.7.1.18
xref: MetaCyc:PHOSPHORIBOKINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050196
name: [phosphorylase] phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate." [EC:3.1.3.17, MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN]
synonym: "glycogen phosphorylase phosphatase activity" EXACT [EC:3.1.3.17]
synonym: "phosphorylase a phosphatase activity" EXACT [EC:3.1.3.17]
synonym: "phosphorylase a phosphohydrolase activity" EXACT [EC:3.1.3.17]
synonym: "phosphorylase phosphatase activity" EXACT []
synonym: "PR-enzyme" RELATED [EC:3.1.3.17]
synonym: "protein phosphatase C" RELATED [EC:3.1.3.17]
synonym: "type 1 protein phosphatase activity" EXACT [EC:3.1.3.17]
xref: EC:3.1.3.17
xref: MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050197
name: phytanate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + phytanate + CoA = AMP + diphosphate + phytanoyl-CoA." [EC:6.2.1.24, MetaCyc:PHYTANATE--COA-LIGASE-RXN]
subset: gosubset_prok
synonym: "phytanate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.24]
synonym: "phytanoyl-CoA ligase activity" EXACT [EC:6.2.1.24]
xref: EC:6.2.1.24
xref: MetaCyc:PHYTANATE--COA-LIGASE-RXN
xref: Reactome:80313 "phytanate-CoA ligase activity"
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0050198
name: pinosylvin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 malonyl-CoA + cinnamoyl-CoA = 4 CoA + pinosylvin + 4 CO2." [EC:2.3.1.146, MetaCyc:PINOSYLVIN-SYNTHASE-RXN]
synonym: "malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.146]
synonym: "pine stilbene synthase activity" EXACT [EC:2.3.1.146]
synonym: "stilbene synthase activity" BROAD [EC:2.3.1.146]
xref: EC:2.3.1.146
xref: MetaCyc:PINOSYLVIN-SYNTHASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050199
name: piperidine N-piperoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = CoA + N-[(E,E)-piperoyl]-piperidine." [EC:2.3.1.145, MetaCyc:PIPERIDINE-N-PIPEROYLTRANSFERASE-RXN]
synonym: "(E,E)-piperoyl-CoA:piperidine N-piperoyltransferase activity" EXACT [EC:2.3.1.145]
synonym: "piperidine piperoyltransferase activity" EXACT [EC:2.3.1.145]
synonym: "piperoyl-CoA:piperidine N-piperoyltransferase activity" EXACT [EC:2.3.1.145]
xref: EC:2.3.1.145
xref: MetaCyc:PIPERIDINE-N-PIPEROYLTRANSFERASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050200
name: plasmalogen synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine." [EC:2.3.1.25, MetaCyc:PLASMALOGEN-SYNTHASE-RXN]
synonym: "1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase activity" EXACT [EC:2.3.1.25]
synonym: "acyl-CoA:1-O-alk-1-enyl-glycero-3-phosphocholine 2-O-acyltransferase activity" EXACT [EC:2.3.1.25]
synonym: "lysoplasmenylcholine acyltransferase activity" EXACT [EC:2.3.1.25]
synonym: "O-1-alkenylglycero-3-phosphorylcholine acyltransferase activity" EXACT [EC:2.3.1.25]
xref: EC:2.3.1.25
xref: MetaCyc:PLASMALOGEN-SYNTHASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050201
name: fucokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 6-deoxy-L-galactose = ADP + 6-deoxy-L-galactose 1-phosphate." [EC:2.7.1.52, MetaCyc:FUCOKINASE-RXN]
synonym: "ATP:6-deoxy-L-galactose 1-phosphotransferase activity" EXACT [EC:2.7.1.52]
synonym: "ATP:beta-L-fucose 1-phosphotransferase activity" EXACT [EC:2.7.1.52]
synonym: "fucokinase (phosphorylating) activity" EXACT [EC:2.7.1.52]
synonym: "fucose kinase activity" EXACT [EC:2.7.1.52]
synonym: "L-fucokinase activity" EXACT [EC:2.7.1.52]
synonym: "L-fucose kinase activity" EXACT [EC:2.7.1.52]
xref: EC:2.7.1.52
xref: MetaCyc:FUCOKINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050202
name: octopamine dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH3." [EC:4.2.1.87, MetaCyc:OCTOPAMINE-DEHYDRATASE-RXN]
synonym: "octopamine hydro-lyase (deaminating)" EXACT [EC:4.2.1.87]
synonym: "octopamine hydro-lyase [deaminating; (4-hydroxyphenyl)acetaldehyde-forming]" RELATED [EC:4.2.1.87]
synonym: "octopamine hydrolyase activity" EXACT [EC:4.2.1.87]
xref: EC:4.2.1.87
xref: MetaCyc:OCTOPAMINE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050203
name: oxalate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + oxalate + CoA = AMP + diphosphate + oxalyl-CoA." [EC:6.2.1.8, MetaCyc:OXALATE--COA-LIGASE-RXN]
synonym: "oxalate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.8]
synonym: "oxalyl coenzyme A synthetase activity" EXACT [EC:6.2.1.8]
synonym: "oxalyl-CoA synthetase activity" EXACT [EC:6.2.1.8]
xref: EC:6.2.1.8
xref: MetaCyc:OXALATE--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0050204
name: oxalomalate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxalomalate = oxaloacetate + glyoxylate." [EC:4.1.3.13, MetaCyc:OXALOMALATE-LYASE-RXN]
synonym: "3-oxalomalate glyoxylate-lyase (oxaloacetate-forming)" EXACT [EC:4.1.3.13]
synonym: "3-oxalomalate glyoxylate-lyase activity" EXACT [EC:4.1.3.13]
xref: EC:4.1.3.13
xref: MetaCyc:OXALOMALATE-LYASE-RXN
is_a: GO:0016833 ! oxo-acid-lyase activity

[Term]
id: GO:0050205
name: oxamate carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbamoyl phosphate + oxamate = phosphate + oxalureate." [EC:2.1.3.5, MetaCyc:OXAMATE-CARBAMOYLTRANSFERASE-RXN]
synonym: "carbamoyl-phosphate:oxamate carbamoyltransferase activity" EXACT [EC:2.1.3.5]
synonym: "oxamic transcarbamylase activity" EXACT [EC:2.1.3.5]
xref: EC:2.1.3.5
xref: MetaCyc:OXAMATE-CARBAMOYLTRANSFERASE-RXN
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0050206
name: oximinotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate oxime + acetone = pyruvate + acetone oxime." [EC:2.6.3.1, MetaCyc:OXIMINOTRANSFERASE-RXN]
synonym: "oximase activity" EXACT [EC:2.6.3.1]
synonym: "pyruvate-acetone oximinotransferase activity" EXACT [EC:2.6.3.1]
synonym: "pyruvate-oxime:acetone oximinotransferase activity" EXACT [EC:2.6.3.1]
synonym: "transoximase activity" EXACT [EC:2.6.3.1]
synonym: "transoximinase activity" EXACT [EC:2.6.3.1]
xref: EC:2.6.3.1
xref: MetaCyc:OXIMINOTRANSFERASE-RXN
is_a: GO:0016770 ! oximinotransaminase activity

[Term]
id: GO:0050207
name: plasmanylethanolamine desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + donor-H2 + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + acceptor + 2 H2O." [EC:1.14.99.19, MetaCyc:PLASMANYLETHANOLAMINE-DESATURASE-RXN]
synonym: "1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity" EXACT [EC:1.14.99.19]
synonym: "1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity" EXACT [EC:1.14.99.19]
synonym: "alkylacylglycero-phosphorylethanolamine dehydrogenase activity" EXACT [EC:1.14.99.19]
synonym: "alkylacylglycerophosphoethanolamine desaturase activity" EXACT [EC:1.14.99.19]
synonym: "dehydrogenase, alkyl-acylglycerophosphorylethanolamine" EXACT [EC:1.14.99.19]
synonym: "O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.19]
synonym: "plasmenylethanolamine desaturase activity" EXACT []
xref: EC:1.14.99.19
xref: MetaCyc:PLASMANYLETHANOLAMINE-DESATURASE-RXN
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050208
name: polysialic-acid O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9." [EC:2.3.1.136, MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA:polysialic-acid O-acetyltransferase activity" EXACT [EC:2.3.1.136]
synonym: "lecithin retinol acyl transferase activity" EXACT [EC:2.3.1.136]
synonym: "lecithin:retinol acyltransferase activity" EXACT [EC:2.3.1.136]
synonym: "LRAT" RELATED [EC:2.3.1.136]
synonym: "retinyl ester synthase activity" EXACT [EC:2.3.1.136]
xref: EC:2.3.1.136
xref: MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050209
name: polyvinyl-alcohol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2." [EC:1.1.3.30, MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN]
synonym: "dehydrogenase, polyvinyl alcohol" EXACT [EC:1.1.3.30]
synonym: "polyvinyl-alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.30]
synonym: "PVA oxidase activity" EXACT [EC:1.1.3.30]
xref: EC:1.1.3.30
xref: MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050210
name: prenyl-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate." [EC:3.1.7.1, MetaCyc:PRENYL-PYROPHOSPHATASE-RXN]
synonym: "prenol pyrophosphatase activity" EXACT [EC:3.1.7.1]
synonym: "prenyl-diphosphate diphosphohydrolase activity" EXACT [EC:3.1.7.1]
synonym: "prenyl-pyrophosphatase activity" EXACT []
synonym: "prenylphosphatase activity" EXACT [EC:3.1.7.1]
xref: EC:3.1.7.1
xref: MetaCyc:PRENYL-PYROPHOSPHATASE-RXN
is_a: GO:0016794 ! diphosphoric monoester hydrolase activity

[Term]
id: GO:0050211
name: procollagen galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine." [EC:2.4.1.50, MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN]
synonym: "collagen galactosyltransferase activity" EXACT [EC:2.4.1.50]
synonym: "collagen hydroxylysyl galactosyltransferase activity" EXACT [EC:2.4.1.50]
synonym: "hydroxylysine galactosyltransferase activity" EXACT [EC:2.4.1.50]
synonym: "UDP galactose-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50]
synonym: "UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity" EXACT [EC:2.4.1.50]
synonym: "UDPgalactose:5-hydroxylysine-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50]
synonym: "UDPgalactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity" EXACT [EC:2.4.1.50]
synonym: "uridine diphosphogalactose-collagen galactosyltransferase activity" EXACT [EC:2.4.1.50]
xref: EC:2.4.1.50
xref: MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0050212
name: progesterone 11-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: progesterone + donor-H2 + O2 = 11-alpha-hydroxyprogesterone + acceptor + H2O." [EC:1.14.99.14, MetaCyc:PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN]
synonym: "progesterone 11-alpha-hydroxylase activity" EXACT [EC:1.14.99.14]
synonym: "progesterone 11a-monooxygenase activity" EXACT []
synonym: "progesterone 11alpha-hydroxylase activity" EXACT [EC:1.14.99.14]
synonym: "progesterone 11alpha-monooxygenase activity" EXACT [EC:1.14.99.14]
synonym: "progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating)" EXACT [EC:1.14.99.14]
xref: EC:1.14.99.14
xref: MetaCyc:PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050213
name: progesterone 5-alpha-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH." [EC:1.3.1.30, MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN]
synonym: "5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase activity" EXACT [EC:1.3.1.30]
synonym: "delta4-steroid 5alpha-reductase (progesterone)" EXACT [EC:1.3.1.30]
synonym: "progesterone 5a-reductase activity" EXACT []
synonym: "progesterone 5alpha-reductase activity" EXACT [EC:1.3.1.30]
synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.1.30]
xref: EC:1.3.1.30
xref: MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050214
name: progesterone monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: progesterone + donor-H2 + O2 = testosterone acetate + acceptor + H2O." [EC:1.14.99.4, MetaCyc:PROGESTERONE-MONOOXYGENASE-RXN]
synonym: "progesterone hydroxylase activity" EXACT [EC:1.14.99.4]
synonym: "progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.99.4]
xref: EC:1.14.99.4
xref: MetaCyc:PROGESTERONE-MONOOXYGENASE-RXN
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050215
name: propanediol dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: propane-1,2-diol = propanal + H2O." [EC:4.2.1.28, MetaCyc:PROPANEDIOL-DEHYDRATASE-RXN]
subset: gosubset_prok
synonym: "1,2-propanediol dehydratase activity" EXACT [EC:4.2.1.28]
synonym: "adenosylcobalamin-dependent diol dehydratase activity" EXACT [EC:4.2.1.28]
synonym: "coenzyme B12-dependent diol dehydrase activity" EXACT [EC:4.2.1.28]
synonym: "diol dehydrase activity" EXACT [EC:4.2.1.28]
synonym: "diol dehydratase activity" EXACT [EC:4.2.1.28]
synonym: "dioldehydratase activity" EXACT [EC:4.2.1.28]
synonym: "DL-1,2-propanediol hydro-lyase activity" EXACT [EC:4.2.1.28]
synonym: "meso-2,3-butanediol dehydrase activity" EXACT [EC:4.2.1.28]
synonym: "propane-1,2-diol hydro-lyase (propanal-forming)" EXACT [EC:4.2.1.28]
synonym: "propane-1,2-diol hydro-lyase activity" EXACT [EC:4.2.1.28]
synonym: "propanediol dehydrase activity" EXACT [EC:4.2.1.28]
xref: EC:4.2.1.28
xref: MetaCyc:PROPANEDIOL-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050216
name: propanediol-phosphate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: propane-1,2-diol 1-phosphate + NAD+ = hydroxyacetone phosphate + NADH." [EC:1.1.1.7, MetaCyc:PROPANEDIOL-PHOSPHATE-DEHYDROGENASE-RXN]
xref: EC:1.1.1.7
xref: MetaCyc:PROPANEDIOL-PHOSPHATE-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050217
name: propioin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 propanal = 4-hydroxy-3-hexanone." [EC:4.1.2.35, MetaCyc:PROPIOIN-SYNTHASE-RXN]
synonym: "4-hydroxy-3-hexanone aldolase activity" EXACT [EC:4.1.2.35]
synonym: "4-hydroxy-3-hexanone propanal-lyase (propanal-forming)" EXACT [EC:4.1.2.35]
synonym: "4-hydroxy-3-hexanone propanal-lyase activity" EXACT [EC:4.1.2.35]
xref: EC:4.1.2.35
xref: MetaCyc:PROPIOIN-SYNTHASE-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050218
name: propionate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA." [EC:6.2.1.17, MetaCyc:PROPIONATE--COA-LIGASE-RXN]
subset: gosubset_prok
synonym: "propanoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.17]
synonym: "propionyl-CoA synthetase activity" EXACT [EC:6.2.1.17]
xref: EC:6.2.1.17
xref: MetaCyc:PROPIONATE--COA-LIGASE-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0050219
name: prostaglandin-A1 delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate = (13E)-(15S)-15-hydroxy-9-oxoprosta-11,13-dienoate." [EC:5.3.3.9, MetaCyc:PROSTAGLANDIN-A1-DELTA-ISOMERASE-RXN]
synonym: "(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate delta10-delta11-isomerase activity" EXACT [EC:5.3.3.9]
synonym: "prostaglandin A isomerase activity" EXACT [EC:5.3.3.9]
synonym: "prostaglandin-A1 D-isomerase activity" EXACT []
xref: EC:5.3.3.9
xref: MetaCyc:PROSTAGLANDIN-A1-DELTA-ISOMERASE-RXN
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0050220
name: prostaglandin-E synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate." [EC:5.3.99.3, MetaCyc:PROSTAGLANDIN-E-SYNTHASE-RXN]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [EC:5.3.99.3]
synonym: "endoperoxide isomerase activity" EXACT [EC:5.3.99.3]
synonym: "PGE isomerase activity" EXACT [EC:5.3.99.3]
synonym: "PGE2 isomerase activity" EXACT [EC:5.3.99.3]
synonym: "PGH-PGE isomerase activity" EXACT [EC:5.3.99.3]
synonym: "prostaglandin endoperoxide E isomerase activity" EXACT [EC:5.3.99.3]
synonym: "prostaglandin endoperoxide E2 isomerase activity" EXACT [EC:5.3.99.3]
synonym: "prostaglandin H-E isomerase activity" EXACT [EC:5.3.99.3]
synonym: "prostaglandin R-prostaglandin E isomerase activity" EXACT [EC:5.3.99.3]
synonym: "Prostaglandin-H(2) E-isomerase activity" EXACT [EC:5.3.99.3]
synonym: "prostaglandin-H2 E-isomerase activity" EXACT [EC:5.3.99.3]
xref: EC:5.3.99.3
xref: MetaCyc:PROSTAGLANDIN-E-SYNTHASE-RXN
xref: Reactome:80371 "prostaglandin-E synthase activity"
is_a: GO:0016860 ! intramolecular oxidoreductase activity

[Term]
id: GO:0050221
name: prostaglandin-E2 9-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH." [EC:1.1.1.189, MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN]
synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase activity" EXACT [EC:1.1.1.189]
synonym: "9-keto-prostaglandin E(2) reductase activity" EXACT [EC:1.1.1.189]
synonym: "9-keto-prostaglandin E2 reductase activity" EXACT [EC:1.1.1.189]
synonym: "9-ketoprostaglandin reductase activity" EXACT [EC:1.1.1.189]
synonym: "PGE(2) 9-ketoreductase activity" EXACT [EC:1.1.1.189]
synonym: "PGE(2) 9-oxoreductase activity" EXACT [EC:1.1.1.189]
synonym: "PGE-9-ketoreductase activity" EXACT [EC:1.1.1.189]
synonym: "PGE2 9-ketoreductase activity" EXACT [EC:1.1.1.189]
synonym: "PGE2 9-oxoreductase activity" EXACT [EC:1.1.1.189]
synonym: "PGE2-9-ketoreductase activity" EXACT [EC:1.1.1.189]
synonym: "PGE2-9-OR" RELATED [EC:1.1.1.189]
synonym: "prostaglandin E 9-ketoreductase activity" EXACT [EC:1.1.1.189]
synonym: "prostaglandin E2-9-oxoreductase activity" EXACT [EC:1.1.1.189]
synonym: "prostaglandin-E(2) 9-oxoreductase activity" EXACT [EC:1.1.1.189]
synonym: "prostaglandin-E2 9-oxoreductase activity" EXACT [EC:1.1.1.189]
synonym: "reductase, 15-hydroxy-9-oxoprostaglandin" EXACT [EC:1.1.1.189]
xref: EC:1.1.1.189
xref: MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050223
name: protocatechuate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxybenzoate = catechol + CO2." [EC:4.1.1.63, MetaCyc:PROTOCATECHUATE-DECARBOXYLASE-RXN]
synonym: "3,4-dihydrobenzoate decarboxylase activity" EXACT [EC:4.1.1.63]
synonym: "3,4-dihydroxybenzoate carboxy-lyase (catechol-forming)" EXACT [EC:4.1.1.63]
synonym: "3,4-dihydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.63]
synonym: "protocatechuate carboxy-lyase activity" EXACT [EC:4.1.1.63]
xref: EC:4.1.1.63
xref: MetaCyc:PROTOCATECHUATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050224
name: prunasin beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-prunasin + H2O = D-glucose + mandelonitrile." [EC:3.2.1.118, MetaCyc:PRUNASIN-BETA-GLUCOSIDASE-RXN]
synonym: "prunasin b-glucosidase activity" EXACT []
synonym: "prunasin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.118]
synonym: "prunasin hydrolase activity" EXACT [EC:3.2.1.118]
xref: EC:3.2.1.118
xref: MetaCyc:PRUNASIN-BETA-GLUCOSIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0050225
name: pseudouridine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pseudouridine = ADP + pseudouridine 5'-phosphate." [EC:2.7.1.83, MetaCyc:PSEUDOURIDINE-KINASE-RXN]
synonym: "ATP:pseudouridine 5'-phosphotransferase activity" EXACT [EC:2.7.1.83]
synonym: "pseudouridine kinase (phosphorylating)" EXACT [EC:2.7.1.83]
xref: EC:2.7.1.83
xref: MetaCyc:PSEUDOURIDINE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050226
name: psychosine sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate." [EC:2.8.2.13, MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN]
synonym: "3'-phosphoadenosine 5'-phosphosulfate-psychosine sulphotransferase activity" EXACT [EC:2.8.2.13]
synonym: "3'-phosphoadenylyl-sulfate:galactosylsphingosine sulfotransferase activity" EXACT [EC:2.8.2.13]
synonym: "PAPS:psychosine sulphotransferase activity" EXACT [EC:2.8.2.13]
synonym: "psychosine sulphotransferase activity" EXACT []
xref: EC:2.8.2.13
xref: MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050227
name: pteridine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown." [EC:1.17.3.1, MetaCyc:PTERIDINE-OXIDASE-RXN]
synonym: "2-amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.17.3.1]
xref: EC:1.17.3.1
xref: MetaCyc:PTERIDINE-OXIDASE-RXN
is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor

[Term]
id: GO:0050228
name: pterin deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3." [EC:3.5.4.11, MetaCyc:PTERIN-DEAMINASE-RXN]
synonym: "2-amino-4-hydroxypteridine aminohydrolase activity" EXACT [EC:3.5.4.11]
synonym: "acrasinase activity" EXACT [EC:3.5.4.11]
xref: EC:3.5.4.11
xref: MetaCyc:PTERIN-DEAMINASE-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0050229
name: pterocarpin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: medicarpin + NADP+ = vestitone + NADPH." [EC:1.1.1.246, MetaCyc:PTEROCARPIN-SYNTHASE-RXN]
synonym: "medicarpin:NADP+ 2'-oxidoreductase activity" EXACT [EC:1.1.1.246]
synonym: "pterocarpan synthase activity" EXACT [EC:1.1.1.246]
xref: EC:1.1.1.246
xref: MetaCyc:PTEROCARPIN-SYNTHASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050230
name: purine imidazole-ring cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O." [EC:4.3.2.4, MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN]
synonym: "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing)" EXACT [EC:4.3.2.4]
synonym: "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing; DNA-adenine-forming)" EXACT [EC:4.3.2.4]
synonym: "DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming)" EXACT [EC:4.3.2.4]
xref: EC:4.3.2.4
xref: MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0050231
name: putrescine carbamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: carbamoyl phosphate + putrescine = phosphate + N-carbamoylputrescine." [EC:2.1.3.6, MetaCyc:PUTRESCINE-CARBAMOYLTRANSFERASE-RXN]
subset: gosubset_prok
synonym: "carbamoyl-phosphate:putrescine carbamoyltransferase activity" EXACT [EC:2.1.3.6]
synonym: "PTCase activity" EXACT [EC:2.1.3.6]
synonym: "putrescine synthase activity" EXACT [EC:2.1.3.6]
synonym: "putrescine transcarbamylase activity" EXACT [EC:2.1.3.6]
xref: EC:2.1.3.6
xref: MetaCyc:PUTRESCINE-CARBAMOYLTRANSFERASE-RXN
is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity

[Term]
id: GO:0050232
name: putrescine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2." [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN]
subset: gosubset_prok
synonym: "putrescine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.10]
xref: EC:1.4.3.10
xref: MetaCyc:PUTRESCINE-OXIDASE-RXN
is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

[Term]
id: GO:0050233
name: pyranose oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose + O2 = 2-dehydro-D-glucose + H2O2." [EC:1.1.3.10, MetaCyc:PYRANOSE-OXIDASE-RXN]
synonym: "glucose 2-oxidase activity" EXACT [EC:1.1.3.10]
synonym: "pyranose-2-oxidase activity" EXACT [EC:1.1.3.10]
synonym: "pyranose:oxygen 2-oxidoreductase activity" EXACT [EC:1.1.3.10]
xref: EC:1.1.3.10
xref: MetaCyc:PYRANOSE-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050234
name: pyrazolylalanine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O." [EC:4.2.1.50, MetaCyc:PYRAZOLYLALANINE-SYNTHASE-RXN]
synonym: "beta-pyrazolylalaninase activity" EXACT [EC:4.2.1.50]
synonym: "L-serine hydro-lyase (adding pyrazole)" EXACT [EC:4.2.1.50]
synonym: "L-serine hydro-lyase [adding pyrazole; 3-(pyrazol-1-yl)-L-alanine-forming]" RELATED [EC:4.2.1.50]
xref: EC:4.2.1.50
xref: MetaCyc:PYRAZOLYLALANINE-SYNTHASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050235
name: pyridoxal 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxal + NAD+ = 4-pyridoxolactone + NADH." [EC:1.1.1.107, MetaCyc:PYRIDOXAL-4-DEHYDROGENASE-RXN]
synonym: "pyridoxal dehydrogenase activity" EXACT [EC:1.1.1.107]
synonym: "pyridoxal:NAD+ 4-oxidoreductase activity" EXACT [EC:1.1.1.107]
xref: EC:1.1.1.107
xref: MetaCyc:PYRIDOXAL-4-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050236
name: pyridoxine 4-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxine + NADP+ = pyridoxal + NADPH." [EC:1.1.1.65, MetaCyc:PYRIDOXINE-4-DEHYDROGENASE-RXN]
synonym: "PL reductase activity" EXACT [EC:1.1.1.65]
synonym: "pyridoxal reductase activity" EXACT [EC:1.1.1.65]
synonym: "pyridoxin dehydrogenase activity" EXACT [EC:1.1.1.65]
synonym: "pyridoxine dehydrogenase activity" EXACT [EC:1.1.1.65]
synonym: "pyridoxine:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.65]
synonym: "pyridoxol dehydrogenase activity" EXACT [EC:1.1.1.65]
xref: EC:1.1.1.65
xref: MetaCyc:PYRIDOXINE-4-DEHYDROGENASE-RXN
is_a: GO:0004033 ! aldo-keto reductase activity

[Term]
id: GO:0050237
name: pyridoxine 4-oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2." [EC:1.1.3.12, MetaCyc:PYRIDOXINE-4-OXIDASE-RXN]
synonym: "pyridoxin 4-oxidase activity" EXACT [EC:1.1.3.12]
synonym: "pyridoxine:oxygen 4-oxidoreductase activity" EXACT [EC:1.1.3.12]
synonym: "pyridoxol 4-oxidase activity" EXACT [EC:1.1.3.12]
xref: EC:1.1.3.12
xref: MetaCyc:PYRIDOXINE-4-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050238
name: pyridoxine 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor." [EC:1.1.99.9, MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN]
synonym: "pyridoxal-5-dehydrogenase activity" EXACT [EC:1.1.99.9]
synonym: "pyridoxin 5-dehydrogenase activity" EXACT [EC:1.1.99.9]
synonym: "pyridoxine 5'-dehydrogenase activity" EXACT [EC:1.1.99.9]
synonym: "pyridoxine:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.9]
synonym: "pyridoxine:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.9]
synonym: "pyridoxol 5-dehydrogenase activity" EXACT [EC:1.1.99.9]
xref: EC:1.1.99.9
xref: MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0050239
name: pyrithiamine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3." [EC:3.5.4.20, MetaCyc:PYRITHIAMIN-DEAMINASE-RXN]
synonym: "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium-bromide aminohydrolase activity" EXACT [EC:3.5.4.20]
xref: EC:3.5.4.20
xref: MetaCyc:PYRITHIAMIN-DEAMINASE-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0050240
name: pyrogallol 1,2-oxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2,3-trihydroxybenzene + O2 = (Z)-5-oxohex-2-enedioate." [EC:1.13.11.35, MetaCyc:PYROGALLOL-12-OXYGENASE-RXN]
synonym: "1,2,3-trihydroxybenzene:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.35]
synonym: "pyrogallol 1,2-dioxygenase activity" EXACT [EC:1.13.11.35]
xref: EC:1.13.11.35
xref: MetaCyc:PYROGALLOL-12-OXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050241
name: pyrroline-2-carboxylate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+." [EC:1.5.1.1, MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN]
synonym: "delta1-pyrroline-2-carboxylate reductase activity" EXACT [EC:1.5.1.1]
synonym: "L-proline:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.5.1.1]
xref: EC:1.5.1.1
xref: MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050242
name: pyruvate, phosphate dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pyruvate + phosphate = AMP + phosphoenolpyruvate + diphosphate." [EC:2.7.9.1, MetaCyc:PYRUVATEORTHOPHOSPHATE-DIKINASE-RXN]
subset: gosubset_prok
synonym: "ATP:pyruvate, phosphate phosphotransferase activity" EXACT [EC:2.7.9.1]
synonym: "orthophosphate dikinase pyruvate" RELATED [EC:2.7.9.1]
synonym: "PPDK" RELATED [EC:2.7.9.1]
synonym: "pyruvate, Pi dikinase activity" EXACT [EC:2.7.9.1]
synonym: "pyruvate,orthophosphate dikinase activity" EXACT [EC:2.7.9.1]
synonym: "pyruvate,phosphate dikinase activity" EXACT [EC:2.7.9.1]
synonym: "pyruvate-inorganic phosphate dikinase activity" EXACT [EC:2.7.9.1]
synonym: "pyruvate-phosphate dikinase (phosphorylating)" EXACT [EC:2.7.9.1]
synonym: "pyruvate-phosphate dikinase activity" EXACT [EC:2.7.9.1]
synonym: "pyruvate-phosphate ligase activity" EXACT [EC:2.7.9.1]
synonym: "pyruvic-phosphate dikinase activity" EXACT [EC:2.7.9.1]
synonym: "pyruvic-phosphate ligase activity" EXACT [EC:2.7.9.1]
xref: EC:2.7.9.1
xref: MetaCyc:PYRUVATEORTHOPHOSPHATE-DIKINASE-RXN
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0050243
name: pyruvate dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH." [EC:1.2.1.51, MetaCyc:PYRUVATE-DEHYDROGENASE-NADP+-RXN]
synonym: "pyruvate:NADP(+) oxidoreductase activity" EXACT [EC:1.2.1.51]
synonym: "pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.1.51]
synonym: "pyruvate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.51]
xref: EC:1.2.1.51
xref: MetaCyc:PYRUVATE-DEHYDROGENASE-NADP+-RXN
is_a: GO:0034603 ! pyruvate dehydrogenase [NAD(P)+] activity

[Term]
id: GO:0050244
name: pyruvate oxidase (CoA-acetylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: pyruvate + CoA + O2 = acetyl-CoA + CO2 + H2O2." [EC:1.2.3.6, MetaCyc:PYRUVATE-OXIDASE-COA-ACETYLATING-RXN]
synonym: "pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.3.6]
xref: EC:1.2.3.6
xref: MetaCyc:PYRUVATE-OXIDASE-COA-ACETYLATING-RXN
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0050245
name: quercitrinase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + quercitrin = L-rhamnose + quercetin." [EC:3.2.1.66, MetaCyc:QUERCITRINASE-RXN]
synonym: "quercitrin 3-L-rhamnohydrolase activity" EXACT [EC:3.2.1.66]
xref: EC:3.2.1.66
xref: MetaCyc:QUERCITRINASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0050246
name: questin monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: questin + NADPH + O2 = sulochrin + NADP+ + H2O." [EC:1.14.13.43, MetaCyc:QUESTIN-MONOOXYGENASE-RXN]
synonym: "questin oxygenase activity" EXACT [EC:1.14.13.43]
synonym: "questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening)" EXACT [EC:1.14.13.43]
xref: EC:1.14.13.43
xref: MetaCyc:QUESTIN-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050247
name: raucaffricine beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + raucaffricine = D-glucose + vomilenine." [EC:3.2.1.125, MetaCyc:RAUCAFFRICINE-BETA-GLUCOSIDASE-RXN]
synonym: "raucaffricine b-glucosidase activity" EXACT []
synonym: "raucaffricine beta-D-glucohydrolase activity" EXACT [EC:3.2.1.125]
synonym: "raucaffricine beta-D-glucosidase activity" EXACT [EC:3.2.1.125]
synonym: "raucaffricine glucosidase activity" EXACT [EC:3.2.1.125]
xref: EC:3.2.1.125
xref: MetaCyc:RAUCAFFRICINE-BETA-GLUCOSIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0050248
name: Renilla-luciferin 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light." [EC:1.13.12.5, MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN]
synonym: "aequorin activity" NARROW [EC:1.13.12.5]
synonym: "luciferase (Renilla luciferin)" EXACT [EC:1.13.12.5]
synonym: "luciferase activity" BROAD [EC:1.13.12.5]
synonym: "Renilla-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.5]
synonym: "Renilla-type luciferase activity" EXACT [EC:1.13.12.5]
synonym: "renilla-type luciferase activity" EXACT [EC:1.13.12.5]
xref: EC:1.13.12.5
xref: MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0050249
name: Renilla-luciferin sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + Renilla luciferin = adenosine 3',5'-bisphosphate + luciferyl sulfate." [EC:2.8.2.10, MetaCyc:RENILLA-LUCIFERIN-SULFOTRANSFERASE-RXN]
synonym: "3'-phosphoadenylyl-sulfate:Renilla luciferin sulfotransferase activity" EXACT [EC:2.8.2.10]
synonym: "luciferin sulfokinase (3'-phosphoadenylyl sulfate:luciferin sulfotransferase)" EXACT [EC:2.8.2.10]
synonym: "luciferin sulfokinase activity" EXACT [EC:2.8.2.10]
synonym: "luciferin sulfotransferase activity" BROAD [EC:2.8.2.10]
synonym: "Renilla-luciferin sulphotransferase activity" EXACT []
xref: EC:2.8.2.10
xref: MetaCyc:RENILLA-LUCIFERIN-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050250
name: retinal oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: retinal + O2 + H2O = retinoate + H2O2." [EC:1.2.3.11, MetaCyc:RETINAL-OXIDASE-RXN]
synonym: "retinal:oxygen oxidoreductase activity" EXACT [EC:1.2.3.11]
synonym: "retinene oxidase activity" RELATED [EC:1.2.3.11]
xref: EC:1.2.3.11
xref: MetaCyc:RETINAL-OXIDASE-RXN
is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor

[Term]
id: GO:0050251
name: retinol isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-retinol = 11-cis-retinol." [EC:5.2.1.7, MetaCyc:RETINOL-ISOMERASE-RXN]
synonym: "all-trans-retinol 11-cis-trans-isomerase activity" EXACT [EC:5.2.1.7]
synonym: "all-trans-retinol isomerase activity" EXACT [EC:5.2.1.7]
xref: EC:5.2.1.7
xref: MetaCyc:RETINOL-ISOMERASE-RXN
is_a: GO:0016859 ! cis-trans isomerase activity

[Term]
id: GO:0050252
name: retinol O-fatty-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester." [EC:2.3.1.76, MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN]
synonym: "acyl-CoA:retinol O-acyltransferase activity" EXACT [EC:2.3.1.76]
synonym: "retinol acyltransferase activity" EXACT [EC:2.3.1.76]
synonym: "retinol fatty-acyltransferase activity" EXACT [EC:2.3.1.76]
xref: EC:2.3.1.76
xref: MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0050253
name: retinyl-palmitate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate." [EC:3.1.1.21, MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN]
synonym: "retinyl ester hydrolase activity" EXACT [EC:3.1.1.21]
synonym: "retinyl palmitate hydrolase activity" EXACT [EC:3.1.1.21]
synonym: "retinyl palmitate hydrolyase activity" EXACT [EC:3.1.1.21]
synonym: "retinyl-palmitate palmitohydrolase activity" EXACT [EC:3.1.1.21]
xref: EC:3.1.1.21
xref: MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050254
name: rhodopsin kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]
synonym: "ATP:rhodopsin phosphotransferase activity" EXACT [EC:2.7.11.14]
synonym: "cone opsin kinase activity" NARROW [EC:2.7.11.14]
synonym: "G-protein-coupled receptor kinase 1 activity" NARROW [EC:2.7.11.14]
synonym: "GPCR kinase 1 activity" NARROW [EC:2.7.11.14]
synonym: "GRK1" RELATED [EC:2.7.11.14]
synonym: "GRK7" RELATED [EC:2.7.11.14]
synonym: "opsin kinase (phosphorylating) activity" EXACT [EC:2.7.11.14]
synonym: "opsin kinase activity" EXACT [EC:2.7.11.14]
synonym: "rhodopsin kinase (phosphorylating) activity" EXACT [EC:2.7.11.14]
synonym: "RK" RELATED [EC:2.7.11.14]
synonym: "STK14" RELATED [EC:2.7.11.14]
xref: EC:2.7.11.14
xref: MetaCyc:2.7.11.14-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0050255
name: ribitol 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: ribitol + NAD+ = D-ribulose + NADH." [EC:1.1.1.56, MetaCyc:RIBITOL-2-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "adonitol dehydrogenase activity" EXACT [EC:1.1.1.56]
synonym: "ribitol dehydrogenase A (wild type)" RELATED [EC:1.1.1.56]
synonym: "ribitol dehydrogenase B (mutant enzyme with different properties)" RELATED [EC:1.1.1.56]
synonym: "ribitol dehydrogenase D (mutant enzyme with different properties)" RELATED [EC:1.1.1.56]
synonym: "ribitol:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.56]
xref: EC:1.1.1.56
xref: MetaCyc:RIBITOL-2-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050256
name: ribitol-5-phosphate 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+." [EC:1.1.1.137, MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "D-ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.137]
synonym: "dehydrogenase, ribitol 5-phosphate" EXACT [EC:1.1.1.137]
xref: EC:1.1.1.137
xref: MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050257
name: riboflavin phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucose 1-phosphate + riboflavin = D-glucose + FMN." [EC:2.7.1.42, MetaCyc:RIBOFLAVIN-PHOSPHOTRANSFERASE-RXN]
synonym: "alpha-D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.42]
synonym: "D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.42]
synonym: "G-1-P phosphotransferase activity" EXACT [EC:2.7.1.42]
synonym: "riboflavine phosphotransferase activity" EXACT [EC:2.7.1.42]
xref: EC:2.7.1.42
xref: MetaCyc:RIBOFLAVIN-PHOSPHOTRANSFERASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050258
name: riboflavinase activity
namespace: molecular_function
def: "Catalysis of the reaction: riboflavin + H2O = ribitol + lumichrome." [EC:3.5.99.1, MetaCyc:RIBOFLAVINASE-RXN]
synonym: "riboflavin hydrolase activity" EXACT [EC:3.5.99.1]
xref: EC:3.5.99.1
xref: MetaCyc:RIBOFLAVINASE-RXN
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0050259
name: ribose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose + NADP+ + H2O = D-ribonate + NADPH." [EC:1.1.1.115, MetaCyc:RIBOSE-1-DEHYDROGENASE-NADP+-RXN]
synonym: "D-ribose dehydrogenase (NADP+)" EXACT [EC:1.1.1.115]
synonym: "D-ribose:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.115]
synonym: "NADP-pentose-dehydrogenase activity" EXACT [EC:1.1.1.115]
xref: EC:1.1.1.115
xref: MetaCyc:RIBOSE-1-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050260
name: ribose-5-phosphate-ammonia ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + ribose 5-phosphate + NH3 = ADP + phosphate + 5-phosphoribosylamine." [EC:6.3.4.7, MetaCyc:RIBOSE-5-PHOSPHATE--AMMONIA-LIGASE-RXN]
synonym: "5-phosphoribosylamine synthetase activity" EXACT [EC:6.3.4.7]
synonym: "ammonia-ribose 5-phosphate aminotransferase activity" EXACT [EC:6.3.4.7]
synonym: "ribose 5-phosphate aminotransferase activity" EXACT [EC:6.3.4.7]
synonym: "ribose-5-phosphate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.4.7]
xref: EC:6.3.4.7
xref: MetaCyc:RIBOSE-5-PHOSPHATE--AMMONIA-LIGASE-RXN
is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds

[Term]
id: GO:0050261
name: ribose isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-ribose = D-ribulose." [EC:5.3.1.20, MetaCyc:RIBOSE-ISOMERASE-RXN]
synonym: "D-ribose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.20]
synonym: "D-ribose isomerase activity" EXACT [EC:5.3.1.20]
synonym: "D-ribose ketol-isomerase activity" EXACT [EC:5.3.1.20]
xref: EC:5.3.1.20
xref: MetaCyc:RIBOSE-ISOMERASE-RXN
is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses

[Term]
id: GO:0050262
name: ribosylnicotinamide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + N-ribosylnicotinamide = ADP + nicotinamide ribonucleotide." [EC:2.7.1.22, MetaCyc:RIBOSYLNICOTINAMIDE-KINASE-RXN]
synonym: "ATP:N-ribosylnicotinamide 5'-phosphotransferase activity" EXACT [EC:2.7.1.22]
synonym: "ribosylnicotinamide kinase (phosphorylating)" EXACT [EC:2.7.1.22]
xref: EC:2.7.1.22
xref: MetaCyc:RIBOSYLNICOTINAMIDE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050263
name: ribosylpyrimidine nucleosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine." [EC:3.2.2.8, MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN]
synonym: "N-ribosylpyrimidine nucleosidase activity" EXACT [EC:3.2.2.8]
synonym: "N-ribosylpyrimidine ribohydrolase activity" EXACT [EC:3.2.2.8]
synonym: "nucleoside ribohydrolase activity" BROAD [EC:3.2.2.8]
synonym: "pyrimidine nucleosidase activity" EXACT [EC:3.2.2.8]
synonym: "pyrimidine-nucleoside ribohydrolase activity" EXACT [EC:3.2.2.8]
synonym: "RihB" RELATED [EC:3.2.2.8]
synonym: "YeiK" RELATED [EC:3.2.2.8]
xref: EC:3.2.2.8
xref: MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0050264
name: rifamycin-B oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: rifamycin B + O2 = rifamycin O + H2O2." [EC:1.10.3.6, MetaCyc:RIFAMYCIN-B-OXIDASE-RXN]
synonym: "rifamycin B oxidase activity" EXACT [EC:1.10.3.6]
synonym: "rifamycin-B-oxidase activity" EXACT []
synonym: "rifamycin-B:oxygen oxidoreductase activity" EXACT [EC:1.10.3.6]
xref: EC:1.10.3.6
xref: MetaCyc:RIFAMYCIN-B-OXIDASE-RXN
is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor

[Term]
id: GO:0050265
name: RNA uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.52, MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN]
synonym: "terminal uridylyltransferase activity" EXACT [EC:2.7.7.52]
synonym: "TUT activity" EXACT [EC:2.7.7.52]
synonym: "UTP:RNA uridylyltransferase activity" EXACT []
xref: EC:2.7.7.52
xref: MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0050266
name: rosmarinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate." [EC:2.3.1.140, MetaCyc:ROSMARINATE-SYNTHASE-RXN]
synonym: "4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase activity" EXACT [EC:2.3.1.140]
synonym: "caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase activity" EXACT [EC:2.3.1.140]
synonym: "caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase activity" EXACT [EC:2.3.1.140]
synonym: "rosmarinic acid synthase activity" EXACT [EC:2.3.1.140]
xref: EC:2.3.1.140
xref: MetaCyc:ROSMARINATE-SYNTHASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050267
name: rubber cis-polyprenylcistransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit." [EC:2.5.1.20, MetaCyc:RUBBER-CIS-POLYPRENYLCISTRANSFERASE-RXN]
synonym: "cis-prenyl transferase activity" EXACT [EC:2.5.1.20]
synonym: "isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase activity" EXACT [EC:2.5.1.20]
synonym: "poly-cis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase activity" EXACT [EC:2.5.1.20]
synonym: "rubber allyltransferase activity" EXACT [EC:2.5.1.20]
synonym: "rubber polymerase activity" EXACT [EC:2.5.1.20]
synonym: "rubber prenyltransferase activity" EXACT [EC:2.5.1.20]
synonym: "rubber transferase activity" BROAD [EC:2.5.1.20]
xref: EC:2.5.1.20
xref: MetaCyc:2.5.1.20-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050268
name: coniferyl-alcohol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH." [EC:1.1.1.194, MetaCyc:RXN-1107]
synonym: "coniferyl-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.194]
xref: EC:1.1.1.194
xref: MetaCyc:RXN-2602
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050269
name: coniferyl-aldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+." [EC:1.2.1.68, MetaCyc:RXN-1241]
subset: gosubset_prok
synonym: "coniferyl aldehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.68]
xref: EC:1.2.1.68
xref: MetaCyc:RXN-1241
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050270
name: S-adenosylhomocysteine deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = S-inosyl-L-homocysteine + NH3." [EC:3.5.4.28, MetaCyc:S-ADENOSYLHOMOCYSTEINE-DEAMINASE-RXN]
synonym: "adenosylhomocysteine deaminase activity" EXACT [EC:3.5.4.28]
synonym: "S-adenosyl-L-homocysteine aminohydrolase activity" EXACT [EC:3.5.4.28]
xref: EC:3.5.4.28
xref: MetaCyc:S-ADENOSYLHOMOCYSTEINE-DEAMINASE-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0050271
name: S-alkylcysteine lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate." [EC:4.4.1.6, MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN]
synonym: "alkyl cysteine lyase activity" EXACT [EC:4.4.1.6]
synonym: "alkylcysteine lyase activity" EXACT [EC:4.4.1.6]
synonym: "S-alkyl-L-cysteinase activity" EXACT [EC:4.4.1.6]
synonym: "S-alkyl-L-cysteine alkylthiol-lyase (deaminating) activity" EXACT [EC:4.4.1.6]
synonym: "S-alkyl-L-cysteine alkylthiol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.6]
synonym: "S-alkyl-L-cysteine lyase activity" EXACT [EC:4.4.1.6]
synonym: "S-alkyl-L-cysteine sulfoxide lyase activity" EXACT [EC:4.4.1.6]
synonym: "S-alkylcysteinase activity" EXACT [EC:4.4.1.6]
xref: EC:4.4.1.6
xref: MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0050272
name: S-carboxymethylcysteine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride." [EC:4.5.1.5, MetaCyc:S-CARBOXYMETHYLCYSTEINE-SYNTHASE-RXN]
synonym: "3-chloro-L-alanine chloride-lyase (adding thioglycolate)" EXACT [EC:4.5.1.5]
synonym: "3-chloro-L-alanine chloride-lyase (adding thioglycolate; S-carboxymethyl-L-cysteine-forming)" EXACT [EC:4.5.1.5]
synonym: "S-carboxymethyl-L-cysteine synthase activity" EXACT [EC:4.5.1.5]
xref: EC:4.5.1.5
xref: MetaCyc:S-CARBOXYMETHYLCYSTEINE-SYNTHASE-RXN
is_a: GO:0016848 ! carbon-halide lyase activity

[Term]
id: GO:0050273
name: S-succinylglutathione hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-succinylglutathione + H2O = glutathione + succinate." [EC:3.1.2.13, MetaCyc:S-SUCCINYLGLUTATHIONE-HYDROLASE-RXN]
xref: EC:3.1.2.13
xref: MetaCyc:S-SUCCINYLGLUTATHIONE-HYDROLASE-RXN
is_a: GO:0016790 ! thiolester hydrolase activity

[Term]
id: GO:0050274
name: salicyl-alcohol beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + salicyl alcohol = UDP + salicin." [EC:2.4.1.172, MetaCyc:SALICYL-ALCOHOL-GLUCOSYLTRANSFERASE-RXN]
synonym: "salicyl-alcohol b-D-glucosyltransferase activity" EXACT []
synonym: "salicyl-alcohol glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:salicyl-alcohol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.172]
synonym: "UDPglucose:salicyl alcohol phenyl-glucosyltransferase activity" EXACT [EC:2.4.1.172]
synonym: "UDPglucose:salicyl-alcohol beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.172]
synonym: "uridine diphosphoglucose-salicyl alcohol 2-glucosyltransferase activity" EXACT [EC:2.4.1.172]
xref: EC:2.4.1.172
xref: MetaCyc:SALICYL-ALCOHOL-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050275
name: scopoletin glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + scopoletin = UDP + scopolin." [EC:2.4.1.128, MetaCyc:SCOPOLETIN-GLUCOSYLTRANSFERASE-RXN]
synonym: "SGTase activity" EXACT [EC:2.4.1.128]
synonym: "UDP-glucose:scopoletin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.128]
synonym: "UDPglucose:scopoletin glucosyltransferase activity" EXACT [EC:2.4.1.128]
synonym: "UDPglucose:scopoletin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.128]
synonym: "uridine diphosphoglucose-scopoletin glucosyltransferase activity" EXACT [EC:2.4.1.128]
xref: EC:2.4.1.128
xref: MetaCyc:SCOPOLETIN-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050276
name: scyllo-inosamine 4-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 1-amino-1-deoxy-scyllo-inositol = ADP + 1-amino-1-deoxy-scyllo-inositol 4-phosphate." [EC:2.7.1.65, MetaCyc:SCYLLO-INOSAMINE-KINASE-RXN]
synonym: "ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase activity" EXACT [EC:2.7.1.65]
synonym: "ATP:inosamine phosphotransferase activity" EXACT [EC:2.7.1.65]
synonym: "scyllo-inosamine kinase (phosphorylating)" EXACT [EC:2.7.1.65]
synonym: "scyllo-inosamine kinase activity" EXACT []
xref: EC:2.7.1.65
xref: MetaCyc:SCYLLO-INOSAMINE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050277
name: sedoheptulokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + sedoheptulose = ADP + sedoheptulose 7-phosphate." [EC:2.7.1.14, MetaCyc:SEDOHEPTULOKINASE-RXN]
synonym: "ATP:sedoheptulose 7-phosphotransferase activity" EXACT [EC:2.7.1.14]
synonym: "heptulokinase activity" EXACT [EC:2.7.1.14]
synonym: "sedoheptulokinase (phosphorylating)" EXACT [EC:2.7.1.14]
xref: EC:2.7.1.14
xref: MetaCyc:SEDOHEPTULOKINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050278
name: sedoheptulose-bisphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate." [EC:3.1.3.37, MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN]
subset: gosubset_prok
synonym: "SBPase activity" EXACT [EC:3.1.3.37]
synonym: "sedoheptulose 1,7-bisphosphatase activity" EXACT [EC:3.1.3.37]
synonym: "sedoheptulose 1,7-diphosphatase activity" EXACT [EC:3.1.3.37]
synonym: "sedoheptulose 1,7-diphosphate phosphatase activity" EXACT [EC:3.1.3.37]
synonym: "sedoheptulose bisphosphatase activity" EXACT [EC:3.1.3.37]
synonym: "sedoheptulose diphosphatase activity" EXACT [EC:3.1.3.37]
synonym: "sedoheptulose-1,7-bisphosphatase activity" EXACT [EC:3.1.3.37]
synonym: "sedoheptulose-1,7-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.37]
xref: EC:3.1.3.37
xref: MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050279
name: sepiapterin deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3." [EC:3.5.4.24, MetaCyc:SEPIAPTERIN-DEAMINASE-RXN]
synonym: "sepiapterin aminohydrolase activity" EXACT [EC:3.5.4.24]
xref: EC:3.5.4.24
xref: MetaCyc:SEPIAPTERIN-DEAMINASE-RXN
is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0050280
name: sequoyitol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-O-methyl-myo-inositol + NAD+ = 5D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADH." [EC:1.1.1.143, MetaCyc:SEQUOYITOL-DEHYDROGENASE-RXN]
synonym: "5-O-methyl-myo-inositol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.143]
xref: EC:1.1.1.143
xref: MetaCyc:SEQUOYITOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050281
name: serine-glyoxylate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine." [EC:2.6.1.45, MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN]
subset: gosubset_prok
synonym: "L-serine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.45]
synonym: "serine--glyoxylate aminotransferase activity" EXACT []
synonym: "SGAT activity" EXACT [EC:2.6.1.45]
xref: EC:2.6.1.45
xref: MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0050282
name: serine 2-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH." [EC:1.4.1.7, MetaCyc:SERINE-DEHYDROGENASE-RXN]
synonym: "L-serine:NAD oxidoreductase (deaminating) activity" EXACT [EC:1.4.1.7]
synonym: "L-serine:NAD+ 2-oxidoreductase (deaminating)" EXACT [EC:1.4.1.7]
synonym: "serine dehydrogenase activity" EXACT []
xref: EC:1.4.1.7
xref: MetaCyc:SERINE-DEHYDROGENASE-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050283
name: serine-sulfate ammonia-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + SO4(2-) (sulfate)." [EC:4.3.1.10, MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN]
synonym: "(L-SOS)lyase activity" EXACT [EC:4.3.1.10]
synonym: "L-serine-O-sulfate ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.10]
synonym: "serine-sulphate ammonia-lyase activity" EXACT []
xref: EC:4.3.1.10
xref: MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN
is_a: GO:0016841 ! ammonia-lyase activity

[Term]
id: GO:0050284
name: sinapate 1-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose." [EC:2.4.1.120, MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN]
synonym: "UDP-glucose:sinapate D-glucosyltransferase activity" EXACT [EC:2.4.1.120]
synonym: "UDPglucose:sinapate D-glucosyltransferase activity" EXACT [EC:2.4.1.120]
synonym: "UDPglucose:sinapic acid glucosyltransferase activity" EXACT [EC:2.4.1.120]
synonym: "uridine 5'-diphosphoglucose-hydroxycinnamic acid acylglucosyltransferase activity" EXACT [EC:2.4.1.120]
synonym: "uridine diphosphoglucose-sinapate glucosyltransferase activity" EXACT [EC:2.4.1.120]
xref: EC:2.4.1.120
xref: MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050285
name: sinapine esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: sinapoylcholine + H2O = sinapate + choline." [EC:3.1.1.49, MetaCyc:SINAPINE-ESTERASE-RXN]
synonym: "aromatic choline esterase activity" EXACT [EC:3.1.1.49]
synonym: "sinapoylcholine sinapohydrolase activity" EXACT [EC:3.1.1.49]
xref: EC:3.1.1.49
xref: MetaCyc:SINAPINE-ESTERASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050286
name: sorbitol-6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sorbitol 6-phosphate + H2O = sorbitol + phosphate." [EC:3.1.3.50, MetaCyc:SORBITOL-6-PHOSPHATASE-RXN]
synonym: "sorbitol-6-phosphate phosphatase activity" EXACT [EC:3.1.3.50]
synonym: "sorbitol-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.50]
xref: EC:3.1.3.50
xref: MetaCyc:SORBITOL-6-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050287
name: sorbose 5-dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-sorbose + NADP+ = 5-dehydro-D-fructose + NADPH." [EC:1.1.1.123, MetaCyc:SORBOSE-5-DEHYDROGENASE-NADP+-RXN]
synonym: "5-keto-D-fructose reductase activity" EXACT [EC:1.1.1.123]
synonym: "5-ketofructose reductase activity" EXACT [EC:1.1.1.123]
synonym: "L-sorbose:NADP+ 5-oxidoreductase activity" EXACT [EC:1.1.1.123]
synonym: "reduced nicotinamide adenine dinucleotide phosphate-linked reductase activity" EXACT [EC:1.1.1.123]
synonym: "sorbose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.123]
xref: EC:1.1.1.123
xref: MetaCyc:SORBOSE-5-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050288
name: sorbose dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-sorbose + acceptor = 5-dehydro-D-fructose + reduced acceptor." [EC:1.1.99.12, MetaCyc:SORBOSE-DEHYDROGENASE-RXN]
synonym: "L-sorbose:(acceptor) 5-oxidoreductase activity" EXACT [EC:1.1.99.12]
synonym: "L-sorbose:acceptor 5-oxidoreductase activity" EXACT [EC:1.1.99.12]
xref: EC:1.1.99.12
xref: MetaCyc:SORBOSE-DEHYDROGENASE-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0050289
name: spermidine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor." [EC:1.5.99.6, MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN]
synonym: "spermidine:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.6]
synonym: "spermidine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.6]
xref: EC:1.5.99.6
xref: MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN
is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors

[Term]
id: GO:0050290
name: sphingomyelin phosphodiesterase D activity
namespace: molecular_function
def: "Catalysis of the reaction: sphingomyelin + H2O = ceramide phosphate + choline." [EC:3.1.4.41, MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-D-RXN]
synonym: "sphingomyelin ceramide-phosphohydrolase activity" EXACT [EC:3.1.4.41]
synonym: "sphingomyelinase D" RELATED [EC:3.1.4.41]
xref: EC:3.1.4.41
xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-D-RXN
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0050291
name: sphingosine N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine. In S. cerevisiae, either dihydrosphingosine (DHS) or phytosphingosine (PHS) can react with C26-fattyacyl-CoA to produce ceramide-I or ceramide-II (also called phytoceramide) respectively. In mammals, DHS is usually acylated with a C18 fatty acid group." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845]
synonym: "acyl-CoA:sphingosine N-acyltransferase activity" EXACT [EC:2.3.1.24]
synonym: "ceramide synthase activity" EXACT []
synonym: "ceramide synthetase activity" EXACT [EC:2.3.1.24]
synonym: "dihydroceramide synthase activity" EXACT []
synonym: "sphingosine acyltransferase activity" EXACT [EC:2.3.1.24]
xref: EC:2.3.1.24
xref: MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0050292
name: steroid 9-alpha-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: pregna-4,9(11)-diene-3,20-dione + donor-H2 + O2 = 9,11-alpha-epoxypregn-4-ene-3,20-dione + acceptor + H2O." [EC:1.14.99.24, MetaCyc:STEROID-9-ALPHA-MONOOXYGENASE-RXN]
synonym: "steroid 9-alpha-hydroxylase activity" EXACT [EC:1.14.99.24]
synonym: "steroid 9a-monooxygenase activity" EXACT []
synonym: "steroid 9alpha-hydroxylase activity" EXACT [EC:1.14.99.24]
synonym: "steroid 9alpha-monooxygenase activity" EXACT [EC:1.14.99.24]
synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (9-epoxidizing)" EXACT [EC:1.14.99.24]
xref: EC:1.14.99.24
xref: MetaCyc:STEROID-9-ALPHA-MONOOXYGENASE-RXN
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050293
name: steroid-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: testololactone + H2O = testolate." [EC:3.1.1.37, MetaCyc:STEROID-LACTONASE-RXN]
synonym: "testololactone lactonohydrolase activity" EXACT [EC:3.1.1.37]
xref: EC:3.1.1.37
xref: MetaCyc:STEROID-LACTONASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050294
name: steroid sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate." [EC:2.8.2.15, MetaCyc:STEROID-SULFOTRANSFERASE-RXN]
synonym: "3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity" EXACT [EC:2.8.2.15]
synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.15]
synonym: "steroid sulphotransferase activity" EXACT []
xref: EC:2.8.2.15
xref: MetaCyc:STEROID-SULFOTRANSFERASE-RXN
xref: Reactome:80520 "steroid sulfotransferase activity"
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050295
name: steryl-beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + cholesteryl-beta-D-glucoside = D-glucose + cholesterol." [EC:3.2.1.104, MetaCyc:STERYL-BETA-GLUCOSIDASE-RXN]
synonym: "cholesteryl-beta-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.104]
synonym: "steryl-b-glucosidase activity" EXACT []
xref: EC:3.2.1.104
xref: MetaCyc:STERYL-BETA-GLUCOSIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0050296
name: stipitatonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: stipitatonate = stipitatate + CO2." [EC:4.1.1.60, MetaCyc:STIPITATONATE-DECARBOXYLASE-RXN]
synonym: "stipitatonate carboxy-lyase (decyclizing)" EXACT [EC:4.1.1.60]
synonym: "stipitatonate carboxy-lyase (decyclizing, stipitatate-forming)" EXACT [EC:4.1.1.60]
xref: EC:4.1.1.60
xref: MetaCyc:STIPITATONATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050297
name: stizolobate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.29, MetaCyc:STIZOLOBATE-SYNTHASE-RXN]
synonym: "3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing)" EXACT [EC:1.13.11.29]
xref: EC:1.13.11.29
xref: MetaCyc:STIZOLOBATE-SYNTHASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050298
name: stizolobinate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.30, MetaCyc:STIZOLOBINATE-SYNTHASE-RXN]
synonym: "3,4-dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing)" EXACT [EC:1.13.11.30]
xref: EC:1.13.11.30
xref: MetaCyc:STIZOLOBINATE-SYNTHASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050299
name: streptomycin 3''-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + streptomycin = ADP + streptomycin 3''-phosphate." [EC:2.7.1.87, MetaCyc:STREPTOMYCIN-3-KINASE-RXN]
subset: gosubset_prok
synonym: "ATP:streptomycin 3''-phosphotransferase activity" EXACT [EC:2.7.1.87]
synonym: "streptomycin 3''-kinase (phosphorylating)" EXACT [EC:2.7.1.87]
synonym: "streptomycin 3''-phosphotransferase activity" EXACT [EC:2.7.1.87]
xref: EC:2.7.1.87
xref: MetaCyc:STREPTOMYCIN-3-KINASE-RXN
is_a: GO:0034071 ! aminoglycoside phosphotransferase activity

[Term]
id: GO:0050300
name: aminoglycoside 6-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + streptomycin = ADP + streptomycin 6-phosphate." [EC:2.7.1.72, MetaCyc:STREPTOMYCIN-6-KINASE-RXN]
subset: gosubset_prok
synonym: "APH(6) activity" EXACT [EC:2.7.1.72]
synonym: "ATP:streptomycin 6-phosphotransferase activity" NARROW [EC:2.7.1.72]
synonym: "SM 6-kinase activity" NARROW [EC:2.7.1.72]
synonym: "streptidine kinase (phosphorylating)" NARROW [EC:2.7.1.72]
synonym: "streptidine kinase activity" NARROW [EC:2.7.1.72]
synonym: "streptomycin 6-kinase (phosphorylating)" NARROW [EC:2.7.1.72]
synonym: "streptomycin 6-kinase activity" NARROW []
synonym: "streptomycin 6-O-phosphotransferase activity" NARROW [EC:2.7.1.72]
synonym: "streptomycin 6-phosphotransferase activity" NARROW [EC:2.7.1.72]
xref: EC:2.7.1.72
xref: MetaCyc:STREPTOMYCIN-6-KINASE-RXN
is_a: GO:0034071 ! aminoglycoside phosphotransferase activity

[Term]
id: GO:0050301
name: streptomycin-6-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: streptomycin 6-phosphate + H2O = streptomycin + phosphate." [EC:3.1.3.39, MetaCyc:STREPTOMYCIN-6-PHOSPHATASE-RXN]
subset: gosubset_prok
synonym: "streptomycin 6-phosphate phosphatase activity" EXACT [EC:3.1.3.39]
synonym: "streptomycin 6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.39]
synonym: "streptomycin-6-P phosphohydrolase activity" EXACT [EC:3.1.3.39]
synonym: "streptomycin-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.39]
xref: EC:3.1.3.39
xref: MetaCyc:STREPTOMYCIN-6-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050302
name: indole-3-acetaldehyde oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + 2 indole acetaldehyde = 2 indole-3-acetic acid (IAA)." [EC:1.2.3.7, MetaCyc:INDOLE-3-ACETALDEHYDE-OXIDASE-RXN]
synonym: "(indol-3-yl)acetaldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.7]
synonym: "AO1" RELATED [EC:1.2.3.7]
synonym: "IAA oxidase activity" EXACT [EC:1.2.3.7]
synonym: "IAAld oxidase activity" EXACT [EC:1.2.3.7]
synonym: "indole-3-acetaldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.7]
synonym: "indoleacetaldehyde oxidase activity" EXACT [EC:1.2.3.7]
xref: EC:1.2.3.7
xref: MetaCyc:INDOLE-3-ACETALDEHYDE-OXIDASE-RXN
is_a: GO:0018488 ! aryl-aldehyde oxidase activity

[Term]
id: GO:0050303
name: lysine 6-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine." [EC:1.4.1.18, MetaCyc:LYSINE-6-DEHYDROGENASE-RXN]
synonym: "L-lysine 6-dehydrogenase activity" EXACT [EC:1.4.1.18]
synonym: "L-lysine epsilon-dehydrogenase activity" EXACT [EC:1.4.1.18]
synonym: "L-lysine:NAD+ 6-oxidoreductase (deaminating)" EXACT [EC:1.4.1.18]
synonym: "LysDH activity" EXACT [EC:1.4.1.18]
xref: EC:1.4.1.18
xref: MetaCyc:LYSINE-6-DEHYDROGENASE-RXN
xref: MetaCyc:PWY-5314
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050304
name: nitrous-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: nitrogen + H2O + acceptor = nitrous oxide + reduced acceptor." [EC:1.7.99.6, MetaCyc:NITROUS-OXIDE-REDUCTASE-RXN]
subset: gosubset_prok
synonym: "N2O reductase activity" EXACT [EC:1.7.99.6]
synonym: "nitrogen:(acceptor) oxidoreductase (N2O-forming)" EXACT [EC:1.7.99.6]
synonym: "nitrogen:acceptor oxidoreductase (N2O-forming)" EXACT [EC:1.7.99.6]
synonym: "nitrous oxide reductase activity" EXACT [EC:1.7.99.6]
xref: EC:1.7.99.6
xref: MetaCyc:NITROUS-OXIDE-REDUCTASE-RXN
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0050305
name: strombine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-(carboxymethyl)-D-alanine + NAD+ + H2O = glycine + pyruvate + NADH." [EC:1.5.1.22, MetaCyc:STROMBINE-DEHYDROGENASE-RXN]
synonym: "N-(carboxymethyl)-D-alanine: NAD+ oxidoreductase activity" EXACT [EC:1.5.1.22]
synonym: "N-(carboxymethyl)-D-alanine:NAD+ oxidoreductase (glycine-forming)" EXACT [EC:1.5.1.22]
synonym: "strombine[N-(carboxymethyl)-D-alanine]dehydrogenase activity" EXACT [EC:1.5.1.22]
xref: EC:1.5.1.22
xref: MetaCyc:STROMBINE-DEHYDROGENASE-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050306
name: sucrose 1F-fructosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose." [EC:2.4.1.99, MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN]
synonym: "SST activity" EXACT [EC:2.4.1.99]
synonym: "sucrose 1(F)-fructosyltransferase activity" EXACT [EC:2.4.1.99]
synonym: "sucrose-sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.99]
synonym: "sucrose:sucrose 1'-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99]
synonym: "sucrose:sucrose 1(F)-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99]
synonym: "sucrose:sucrose 1-fructosyltransferase activity" EXACT [EC:2.4.1.99]
synonym: "sucrose:sucrose 1F-beta-D-fructosyltransferase activity" EXACT [EC:2.4.1.99]
synonym: "sucrose:sucrose fructosyltransferase activity" EXACT [EC:2.4.1.99]
xref: EC:2.4.1.99
xref: MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN
is_a: GO:0050738 ! fructosyltransferase activity

[Term]
id: GO:0050307
name: sucrose-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate." [EC:3.1.3.24, MetaCyc:SUCROSE-PHOSPHATASE-RXN]
subset: gosubset_prok
synonym: "sucrose 6-phosphate hydrolase activity" EXACT [EC:3.1.3.24]
synonym: "sucrose-6-phosphatase activity" EXACT [EC:3.1.3.24]
synonym: "sucrose-6F-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.24]
synonym: "sucrose-phosphate hydrolase activity" EXACT [EC:3.1.3.24]
synonym: "sucrose-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.24]
xref: EC:3.1.3.24
xref: MetaCyc:SUCROSE-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050308
name: sugar-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate." [EC:3.1.3.23, MetaCyc:SUGAR-PHOSPHATASE-RXN]
synonym: "sugar-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.23]
xref: EC:3.1.3.23
xref: MetaCyc:SUGAR-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050309
name: sugar-terminal-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a sugar phosphate = a sugar + phosphate; an example is D-glucose 6-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.58, MetaCyc:SUGAR-TERMINAL-PHOSPHATASE-RXN]
synonym: "sugar-omega-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.58]
synonym: "xylitol-5-phosphatase activity" EXACT [EC:3.1.3.58]
xref: EC:3.1.3.58
xref: MetaCyc:SUGAR-TERMINAL-PHOSPHATASE-RXN
is_a: GO:0019203 ! carbohydrate phosphatase activity

[Term]
id: GO:0050310
name: sulfite dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: SO3(2-) (sulfite) + 2 ferricytochrome c + H2O = SO4(2-) (sulfate) + 2 ferrocytochrome c." [EC:1.8.2.1, MetaCyc:SULFITE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "sulfite cytochrome c reductase activity" EXACT [EC:1.8.2.1]
synonym: "sulfite-cytochrome c oxidoreductase activity" EXACT [EC:1.8.2.1]
synonym: "sulfite:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.8.2.1]
synonym: "sulphite dehydrogenase activity" EXACT []
xref: EC:1.8.2.1
xref: MetaCyc:SULFITE-DEHYDROGENASE-RXN
is_a: GO:0016669 ! oxidoreductase activity, acting on sulfur group of donors, cytochrome as acceptor

[Term]
id: GO:0050311
name: sulfite reductase (ferredoxin) activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = SO3(2-) (sulfite) + 3 reduced ferredoxin." [EC:1.8.7.1, MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN]
subset: gosubset_prok
synonym: "ferredoxin-sulfite reductase activity" EXACT [EC:1.8.7.1]
synonym: "hydrogen-sulfide:ferredoxin oxidoreductase activity" EXACT [EC:1.8.7.1]
synonym: "sulphite reductase (ferredoxin) activity" EXACT []
xref: EC:1.8.7.1
xref: MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN
is_a: GO:0016673 ! oxidoreductase activity, acting on sulfur group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0050312
name: sulfoacetaldehyde lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + SO3(2-) (sulfite)." [EC:4.4.1.12, MetaCyc:SULFOACETALDEHYDE-LYASE-RXN]
comment: Note that EC:4.4.1.12 was deleted from EC as the reaction is performed by sulfoacetaldehyde acetyltransferase (EC:2.3.3.15).
synonym: "sulphoacetaldehyde lyase activity" EXACT []
xref: EC:4.4.1.-
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0050313
name: sulfur dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: sulfur + O2 + H2O = SO3(2-) (sulfite)." [EC:1.13.11.18, MetaCyc:SULFUR-DIOXYGENASE-RXN]
synonym: "S-sulfanylglutathione:oxygen oxidoreductase activity" EXACT [EC:1.13.11.18]
synonym: "sulfur oxygenase activity" EXACT [EC:1.13.11.18]
synonym: "sulfur:oxygen oxidoreductase activity" EXACT [EC:1.13.11.18]
synonym: "sulphur dioxygenase activity" EXACT []
xref: EC:1.13.11.18
xref: MetaCyc:SULFUR-DIOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050314
name: sym-norspermidine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosylmethioninamine + propane-1,3-diamine = 5'-methylthioadenosine + bis(3-aminopropyl)amine." [EC:2.5.1.23, MetaCyc:SYM-NORSPERMIDINE-SYNTHASE-RXN]
synonym: "S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.23]
xref: EC:2.5.1.23
xref: MetaCyc:SYM-NORSPERMIDINE-SYNTHASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050315
name: synephrine dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-(methylamino)ethanol = (4-hydroxyphenyl)acetaldehyde + methylamine." [EC:4.2.1.88, MetaCyc:SYNEPHRINE-DEHYDRATASE-RXN]
synonym: "1-(4-hydroxyphenyl)-2-(methylamino)ethanol hydro-lyase (methylamine-forming)" EXACT [EC:4.2.1.88]
xref: EC:4.2.1.88
xref: MetaCyc:SYNEPHRINE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050316
name: T2-induced deoxynucleotide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + dGMP (or dTMP) = ADP + dGDP (or dTDP)." [EC:2.7.4.12, MetaCyc:T2-INDUCED-DEOXYNUCLEOTIDE-KINASE-RXN]
synonym: "ATP:(d)NMP phosphotransferase activity" EXACT [EC:2.7.4.12]
xref: EC:2.7.4.12
xref: MetaCyc:GMKALT-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0050317
name: tagatose kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-tagatose = ADP + D-tagatose 6-phosphate." [EC:2.7.1.101, MetaCyc:TAGATOSE-KINASE-RXN]
synonym: "ATP:D-tagatose 6-phosphotransferase activity" EXACT [EC:2.7.1.101]
synonym: "D-tagatose 6-phosphate kinase activity" EXACT [EC:2.7.1.101]
synonym: "tagatose 6-phosphate kinase (phosphorylating)" EXACT [EC:2.7.1.101]
xref: EC:2.7.1.101
xref: MetaCyc:TAGATOSE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050318
name: tannase activity
namespace: molecular_function
def: "Catalysis of the reaction: digallate + H2O = 2 gallate." [EC:3.1.1.20, MetaCyc:TANNASE-RXN]
synonym: "tannase S" RELATED [EC:3.1.1.20]
synonym: "tannin acetylhydrolase activity" EXACT [EC:3.1.1.20]
synonym: "tannin acylhydrolase activity" EXACT [EC:3.1.1.20]
xref: EC:3.1.1.20
xref: MetaCyc:TANNASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050319
name: tartrate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R,R)-tartrate = D-glycerate + CO2." [EC:4.1.1.73, MetaCyc:TARTRATE-DECARBOXYLASE-RXN]
synonym: "(R,R)-tartrate carboxy-lyase (D-glycerate-forming)" EXACT [EC:4.1.1.73]
synonym: "(R,R)-tartrate carboxy-lyase activity" EXACT [EC:4.1.1.73]
xref: EC:4.1.1.73
xref: MetaCyc:TARTRATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050320
name: tartrate epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R,R)-tartrate = meso-tartrate." [EC:5.1.2.5, MetaCyc:TARTRATE-EPIMERASE-RXN]
synonym: "tartaric racemase activity" EXACT [EC:5.1.2.5]
xref: EC:5.1.2.5
xref: MetaCyc:TARTRATE-EPIMERASE-RXN
is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives

[Term]
id: GO:0050321
name: tau-protein kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]
synonym: "[Tau protein] kinase activity" EXACT []
synonym: "ATP:tau-protein O-phosphotransferase activity" BROAD [EC:2.7.11.26]
synonym: "brain protein kinase PK40erk activity" NARROW [EC:2.7.11.26]
synonym: "cdk5/p20" RELATED [EC:2.7.11.26]
synonym: "CDK5/p23" RELATED [EC:2.7.11.26]
synonym: "glycogen synthase kinase-3beta activity" EXACT [EC:2.7.11.26]
synonym: "GSK" RELATED [EC:2.7.11.26]
synonym: "protein tau kinase activity" EXACT [EC:2.7.11.26]
synonym: "STK31" RELATED [EC:2.7.11.26]
synonym: "tau kinase activity" EXACT [EC:2.7.11.26]
synonym: "tau protein kinase activity" EXACT [EC:2.7.11.26]
synonym: "tau-protein kinase I activity" NARROW [EC:2.7.11.26]
synonym: "tau-protein kinase II activity" NARROW [EC:2.7.11.26]
synonym: "tau-tubulin kinase activity" NARROW [EC:2.7.11.26]
synonym: "TPK" RELATED [EC:2.7.11.26]
synonym: "TPK I" RELATED [EC:2.7.11.26]
synonym: "TPK II" RELATED [EC:2.7.11.26]
synonym: "TTK" RELATED [EC:2.7.11.26]
xref: EC:2.7.11.26
xref: MetaCyc:TAU-PROTEIN-KINASE-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0050322
name: taurine-2-oxoglutarate transaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate." [EC:2.6.1.55, MetaCyc:TAURINE-AMINOTRANSFERASE-RXN]
synonym: "taurine aminotransferase activity" EXACT []
synonym: "taurine transaminase activity" EXACT []
synonym: "taurine--alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.55]
synonym: "taurine--glutamate transaminase activity" EXACT [EC:2.6.1.55]
synonym: "taurine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.55]
xref: EC:2.6.1.55
xref: MetaCyc:TAURINE-AMINOTRANSFERASE-RXN
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0050323
name: taurine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: taurine + H2O + acceptor = sulfoacetaldehyde + NH3 + reduced acceptor." [EC:1.4.99.2, MetaCyc:TAURINE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "taurine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.2]
synonym: "taurine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.2]
xref: EC:1.4.99.2
xref: MetaCyc:TAURINE-DEHYDROGENASE-RXN
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0050324
name: taurocyamine kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + taurocyamine = ADP + N-phosphotaurocyamine." [EC:2.7.3.4, MetaCyc:TAUROCYAMINE-KINASE-RXN]
synonym: "ATP:taurocyamine N-phosphotransferase activity" EXACT [EC:2.7.3.4]
synonym: "ATP:taurocyamine phosphotransferase activity" EXACT [EC:2.7.3.4]
synonym: "taurocyamine phosphotransferase activity" EXACT [EC:2.7.3.4]
xref: EC:2.7.3.4
xref: MetaCyc:TAUROCYAMINE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor

[Term]
id: GO:0050325
name: tauropine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tauropine + NAD+ + H2O = taurine + pyruvate + NADH." [EC:1.5.1.23, MetaCyc:TAUROPINE-DEHYDROGENASE-RXN]
synonym: "2-N-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)" EXACT [EC:1.5.1.23]
synonym: "N2-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)" EXACT [EC:1.5.1.23]
xref: EC:1.5.1.23
xref: MetaCyc:TAUROPINE-DEHYDROGENASE-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050326
name: taxifolin 8-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O." [EC:1.14.13.19, MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN]
synonym: "taxifolin hydroxylase activity" EXACT []
synonym: "taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating)" EXACT [EC:1.14.13.19]
xref: EC:1.14.13.19
xref: MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050327
name: testosterone 17-beta-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH." [EC:1.1.1.63, MetaCyc:TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN]
synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.63]
synonym: "17-ketoreductase activity" BROAD [EC:1.1.1.63]
synonym: "17beta-HSD" RELATED [EC:1.1.1.63]
synonym: "17beta-hydroxysteroid:NAD+ 17-oxidoreductase activity" EXACT [EC:1.1.1.63]
synonym: "testosterone 17b-dehydrogenase activity" EXACT []
synonym: "testosterone 17beta-dehydrogenase activity" EXACT [EC:1.1.1.63]
xref: EC:1.1.1.63
xref: MetaCyc:TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN
xref: Reactome:80588 "testosterone 17-beta-dehydrogenase activity"
is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050328
name: tetrahydroberberine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2." [EC:1.3.3.8, MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN]
synonym: "(S)-tetrahydroberberine:oxygen oxidoreductase activity" EXACT [EC:1.3.3.8]
synonym: "(S)-THB oxidase activity" EXACT [EC:1.3.3.8]
synonym: "THB oxidase activity" EXACT [EC:1.3.3.8]
xref: EC:1.3.3.8
xref: MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0050329
name: tetrahydroxypteridine cycloisomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: tetrahydroxypteridine = xanthine-8-carboxylate." [EC:5.5.1.3, MetaCyc:TETRAHYDROXYPTERIDINE-CYCLOISOMERASE-RXN]
synonym: "tetrahydroxypteridine lyase (isomerizing)" EXACT [EC:5.5.1.3]
xref: EC:5.5.1.3
xref: MetaCyc:TETRAHYDROXYPTERIDINE-CYCLOISOMERASE-RXN
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0050330
name: theanine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N5-ethyl-L-glutamine + H2O = L-glutamate + ethylamine." [EC:3.5.1.65, MetaCyc:THEANINE-HYDROLASE-RXN]
synonym: "5-N-ethyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.65]
synonym: "L-theanine amidohydrolase activity" EXACT [EC:3.5.1.65]
synonym: "N5-ethyl-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.65]
xref: EC:3.5.1.65
xref: MetaCyc:THEANINE-HYDROLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050331
name: thiamin diphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate." [EC:2.7.4.15, MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN]
synonym: "ATP:thiamin-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15]
synonym: "ATP:thiamine-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15]
synonym: "protein bound thiamin diphosphate:ATP phosphoryltransferase activity" EXACT [EC:2.7.4.15]
synonym: "TDP kinase activity" EXACT [EC:2.7.4.15]
synonym: "thiamin diphosphate phosphotransferase activity" EXACT [EC:2.7.4.15]
synonym: "thiamin pyrophosphate kinase activity" EXACT [EC:2.7.4.15]
synonym: "thiamin-diphosphate kinase activity" EXACT []
synonym: "thiamine diphosphate kinase activity" EXACT [EC:2.7.4.15]
synonym: "thiamine-diphosphate kinase activity" EXACT []
xref: EC:2.7.4.15
xref: MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor

[Term]
id: GO:0050332
name: thiamin pyridinylase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiamin + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole." [EC:2.5.1.2, MetaCyc:THIAMIN-PYRIDINYLASE-RXN]
subset: gosubset_prok
synonym: "pyrimidine transferase activity" EXACT [EC:2.5.1.2]
synonym: "thiamin hydrolase activity" EXACT [EC:2.5.1.2]
synonym: "thiamin pyridinolase activity" EXACT [EC:2.5.1.2]
synonym: "thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.2]
synonym: "thiaminase I activity" NARROW [EC:2.5.1.2]
synonym: "thiamine hydrolase activity" EXACT [EC:2.5.1.2]
synonym: "thiamine pyridinolase activity" EXACT [EC:2.5.1.2]
synonym: "thiamine pyridinylase activity" EXACT []
synonym: "thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.2]
xref: EC:2.5.1.2
xref: MetaCyc:THIAMIN-PYRIDINYLASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050333
name: thiamin-triphosphatase activity
namespace: molecular_function
alt_id: GO:0048253
def: "Catalysis of the reaction: thiamin triphosphate + H2O = thiamin diphosphate + phosphate." [EC:3.6.1.28, MetaCyc:THIAMIN-TRIPHOSPHATASE-RXN]
synonym: "thiamine-triphosphatase activity" EXACT []
synonym: "thiamine-triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.28]
synonym: "ThTPase activity" EXACT [EC:3.6.1.28]
xref: EC:3.6.1.28
xref: MetaCyc:THIAMIN-TRIPHOSPHATASE-RXN
is_a: GO:0017111 ! nucleoside-triphosphatase activity

[Term]
id: GO:0050334
name: thiaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiamin + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole." [EC:3.5.99.2, MetaCyc:THIAMINASE-RXN]
synonym: "thiaminase II activity" NARROW [EC:3.5.99.2]
xref: EC:3.5.99.2
xref: MetaCyc:THIAMINASE-RXN
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

[Term]
id: GO:0050335
name: thiocyanate isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate." [EC:5.99.1.1, MetaCyc:THIOCYANATE-ISOMERASE-RXN]
synonym: "benzyl-thiocyanate isomerase activity" EXACT [EC:5.99.1.1]
synonym: "isothiocyanate isomerase activity" EXACT [EC:5.99.1.1]
xref: EC:5.99.1.1
xref: MetaCyc:THIOCYANATE-ISOMERASE-RXN
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0050336
name: thioethanolamine S-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + thioethanolamine = CoA + S-acetylthioethanolamine." [EC:2.3.1.11, MetaCyc:THIOETHANOLAMINE-S-ACETYLTRANSFERASE-RXN]
synonym: "acetyl-CoA:2-aminoethanethiol S-acetyltransferase activity" EXACT [EC:2.3.1.11]
synonym: "acetyl-CoA:thioethanolamine S-acetyltransferase activity" EXACT [EC:2.3.1.11]
synonym: "thioethanolamine acetyltransferase activity" EXACT [EC:2.3.1.11]
synonym: "thioltransacetylase B activity" EXACT [EC:2.3.1.11]
xref: EC:2.3.1.11
xref: MetaCyc:THIOETHANOLAMINE-S-ACETYLTRANSFERASE-RXN
is_a: GO:0016418 ! S-acetyltransferase activity

[Term]
id: GO:0050337
name: thiosulfate-thiol sulfurtransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiosulfate + 2 glutathione = SO3(2-) (sulfite) + glutathione disulfide + sulfide." [EC:2.8.1.3, MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN]
synonym: "glutathione-dependent thiosulfate reductase activity" EXACT [EC:2.8.1.3]
synonym: "sulfane reductase activity" EXACT [EC:2.8.1.3]
synonym: "sulfane sulfurtransferase activity" EXACT [EC:2.8.1.3]
synonym: "thiosulfate:thiol sulfurtransferase activity" EXACT [EC:2.8.1.3]
synonym: "thiosulphate-thiol sulphurtransferase activity" EXACT []
xref: EC:2.8.1.3
xref: MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN
is_a: GO:0016783 ! sulfurtransferase activity

[Term]
id: GO:0050338
name: thiosulfate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c." [EC:1.8.2.2, MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN]
synonym: "tetrathionate synthase activity" EXACT [EC:1.8.2.2]
synonym: "thiosulfate oxidase activity" EXACT [EC:1.8.2.2]
synonym: "thiosulfate-acceptor oxidoreductase activity" EXACT [EC:1.8.2.2]
synonym: "thiosulfate-oxidizing enzyme" RELATED [EC:1.8.2.2]
synonym: "thiosulfate:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.8.2.2]
synonym: "thiosulphate dehydrogenase activity" EXACT []
xref: EC:1.8.2.2
xref: MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN
is_a: GO:0016669 ! oxidoreductase activity, acting on sulfur group of donors, cytochrome as acceptor

[Term]
id: GO:0050339
name: thymidine-triphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTTP + H2O = dTDP + phosphate." [EC:3.6.1.39, MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN]
synonym: "deoxythymidine-5'-triphosphatase activity" EXACT [EC:3.6.1.39]
synonym: "dTTP nucleotidohydrolase activity" EXACT [EC:3.6.1.39]
synonym: "dTTPase activity" EXACT [EC:3.6.1.39]
synonym: "thymidine triphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.39]
xref: EC:3.6.1.39
xref: MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN
is_a: GO:0017111 ! nucleoside-triphosphatase activity

[Term]
id: GO:0050340
name: thymidylate 5'-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate." [EC:3.1.3.35, MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN]
synonym: "deoxythymidylate 5'-nucleotidase activity" EXACT [EC:3.1.3.35]
synonym: "deoxythymidylate phosphohydrolase activity" EXACT [EC:3.1.3.35]
synonym: "deoxythymidylic 5'-nucleotidase activity" EXACT [EC:3.1.3.35]
synonym: "dTMPase activity" EXACT [EC:3.1.3.35]
synonym: "thymidylate 5' phosphatase activity" EXACT []
synonym: "thymidylate 5'-nucleotidase activity" EXACT [EC:3.1.3.35]
synonym: "thymidylate 5'-phosphohydrolase activity" EXACT [EC:3.1.3.35]
synonym: "thymidylate nucleotidase activity" EXACT [EC:3.1.3.35]
xref: EC:3.1.3.35
xref: MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050341
name: thymine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2." [EC:1.14.11.6, MetaCyc:THYMINE-DIOXYGENASE-RXN]
synonym: "5-hydroxy-methyluracil dioxygenase activity" EXACT [EC:1.14.11.6]
synonym: "5-hydroxymethyluracil oxygenase activity" EXACT [EC:1.14.11.6]
synonym: "thymine 7-hydroxylase activity" EXACT [EC:1.14.11.6]
synonym: "thymine,2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.6]
synonym: "thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating)" EXACT [EC:1.14.11.6]
xref: EC:1.14.11.6
xref: MetaCyc:THYMINE-DIOXYGENASE-RXN
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0050342
name: tocopherol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol." [EC:2.1.1.95, MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN]
synonym: "gamma-tocopherol methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase activity" EXACT [EC:2.1.1.95]
xref: EC:2.1.1.95
xref: MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0050343
name: trans-2-enoyl-CoA reductase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH." [EC:1.3.1.44, MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN]
synonym: "acyl-CoA:NAD+ trans-2-oxidoreductase activity" EXACT [EC:1.3.1.44]
xref: EC:1.3.1.44
xref: MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050344
name: trans-cinnamate 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-cinnamate + NADPH + O2 = 2-hydroxycinnamate + NADP+ + H2O." [EC:1.14.13.14, MetaCyc:TRANS-CINNAMATE-2-MONOOXYGENASE-RXN]
synonym: "cinnamate 2-hydroxylase activity" EXACT [EC:1.14.13.14]
synonym: "cinnamate 2-monooxygenase activity" EXACT [EC:1.14.13.14]
synonym: "cinnamic 2-hydroxylase activity" EXACT [EC:1.14.13.14]
synonym: "cinnamic acid 2-hydroxylase activity" EXACT [EC:1.14.13.14]
synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.14]
synonym: "trans-cinnamic acid 2-hydroxylase activity" EXACT []
xref: EC:1.14.13.14
xref: MetaCyc:TRANS-CINNAMATE-2-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050345
name: trans-epoxysuccinate hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + trans-2,3-epoxysuccinate = meso-tartrate." [EC:3.3.2.4, MetaCyc:TRANS-EPOXYSUCCINATE-HYDROLASE-RXN]
synonym: "tartrate epoxydase activity" EXACT [EC:3.3.2.4]
synonym: "trans-2,3-epoxysuccinate hydrolase activity" EXACT [EC:3.3.2.4]
synonym: "trans-epoxysuccinate hydratase activity" EXACT [EC:3.3.2.4]
xref: EC:3.3.2.4
xref: MetaCyc:TRANS-EPOXYSUCCINATE-HYDROLASE-RXN
is_a: GO:0016803 ! ether hydrolase activity

[Term]
id: GO:0050346
name: trans-L-3-hydroxyproline dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-L-3-hydroxyproline = H2O + delta(1)-pyrroline_2-carboxylate." [EC:4.2.1.77, MetaCyc:TRANS-L-3-HYDROXYPROLINE-DEHYDRATASE-RXN]
synonym: "trans-L-3-hydroxyproline hydro-lyase (Delta1-pyrroline 2-carboxylate-forming)" EXACT [EC:4.2.1.77]
synonym: "trans-L-3-hydroxyproline hydro-lyase activity" EXACT [EC:4.2.1.77]
xref: EC:4.2.1.77
xref: MetaCyc:TRANS-L-3-HYDROXYPROLINE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050347
name: trans-octaprenyltranstransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-nonaprenyl diphosphate." [EC:2.5.1.11, MetaCyc:TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN]
synonym: "(E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase activity" EXACT [EC:2.5.1.11]
synonym: "all-trans-nonaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.11]
synonym: "nonaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11]
synonym: "polyprenylpyrophosphate synthetase activity" EXACT [EC:2.5.1.11]
synonym: "solanesyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11]
synonym: "solanesyl-diphosphate synthase activity" EXACT [EC:2.5.1.11]
synonym: "SPP synthase activity" EXACT [EC:2.5.1.11]
synonym: "terpenoidallyltransferase activity" EXACT [EC:2.5.1.11]
synonym: "terpenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.11]
synonym: "trans-prenyltransferase activity" EXACT [EC:2.5.1.11]
xref: EC:2.5.1.11
xref: MetaCyc:TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050348
name: trehalose O-mycolyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose + alpha,alpha'-trehalose 6,6'-bismycolate." [EC:2.3.1.122, MetaCyc:TREHALOSE-O-MYCOLYLTRANSFERASE-RXN]
subset: gosubset_prok
synonym: "alpha,alpha'-trehalose 6-monomycolate:alpha,alpha'-trehalose mycolyltransferase activity" EXACT [EC:2.3.1.122]
synonym: "alpha,alpha'-trehalose-6-mycolate:alpha,alpha'-trehalose-6-mycolate 6'-mycolyltransferase activity" EXACT [EC:2.3.1.122]
xref: EC:2.3.1.122
xref: MetaCyc:RXN1G-874
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050349
name: triacetate-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: triacetate lactone + H2O = triacetate." [EC:3.1.1.38, MetaCyc:TRIACETATE-LACTONASE-RXN]
synonym: "TAL hydrolase activity" EXACT [EC:3.1.1.38]
synonym: "triacetate lactone hydrolase activity" EXACT [EC:3.1.1.38]
synonym: "triacetic acid lactone hydrolase activity" EXACT [EC:3.1.1.38]
synonym: "triacetic lactone hydrolase activity" EXACT [EC:3.1.1.38]
synonym: "triacetolactone lactonohydrolase activity" EXACT [EC:3.1.1.38]
xref: EC:3.1.1.38
xref: MetaCyc:TRIACETATE-LACTONASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050350
name: trihydroxystilbene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2." [EC:2.3.1.95, MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN]
synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.95]
synonym: "resveratrol synthase activity" EXACT [EC:2.3.1.95]
synonym: "stilbene synthase activity" BROAD [EC:2.3.1.95]
xref: EC:2.3.1.95
xref: MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050351
name: trimetaphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: trimetaphosphate + H2O = triphosphate." [EC:3.6.1.2, MetaCyc:TRIMETAPHOSPHATASE-RXN]
subset: gosubset_prok
synonym: "inorganic trimetaphosphatase activity" EXACT [EC:3.6.1.2]
synonym: "trimetaphosphate hydrolase activity" EXACT [EC:3.6.1.2]
xref: EC:3.6.1.2
xref: MetaCyc:TRIMETAPHOSPHATASE-RXN
is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

[Term]
id: GO:0050352
name: trimethylamine-oxide aldolase activity
namespace: molecular_function
def: "Catalysis of the reaction: (CH3)3NO = (CH3)2NH + formaldehyde." [EC:4.1.2.32, MetaCyc:TRIMETHYLAMINE-OXIDE-ALDOLASE-RXN]
synonym: "trimethylamine N-oxide aldolase activity" EXACT [EC:4.1.2.32]
synonym: "trimethylamine N-oxide demethylase activity" EXACT [EC:4.1.2.32]
synonym: "trimethylamine N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.32]
synonym: "trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming)" EXACT [EC:4.1.2.32]
synonym: "trimethylamine-N-oxide formaldehyde-lyase activity" EXACT [EC:4.1.2.32]
xref: EC:4.1.2.32
xref: MetaCyc:TRIMETHYLAMINE-OXIDE-ALDOLASE-RXN
xref: UM-BBD_enzymeID:e0875
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050353
name: trimethyllysine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 = 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2." [EC:1.14.11.8, MetaCyc:TRIMETHYLLYSINE-DIOXYGENASE-RXN]
synonym: "6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.8]
synonym: "epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.8]
synonym: "N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.8]
synonym: "TML dioxygenase activity" EXACT [EC:1.14.11.8]
synonym: "TML hydroxylase activity" EXACT [EC:1.14.11.8]
synonym: "TML-alpha-ketoglutarate dioxygenase activity" EXACT [EC:1.14.11.8]
synonym: "TMLD activity" EXACT [EC:1.14.11.8]
synonym: "trimethyllysine alpha-ketoglutarate dioxygenase activity" EXACT [EC:1.14.11.8]
synonym: "trimethyllysine,2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.8]
xref: EC:1.14.11.8
xref: MetaCyc:TRIMETHYLLYSINE-DIOXYGENASE-RXN
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0050354
name: triokinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate." [EC:2.7.1.28, MetaCyc:TRIOKINASE-RXN]
synonym: "ATP:D-glyceraldehyde 3-phosphotransferase activity" EXACT [EC:2.7.1.28]
synonym: "D-triokinase activity" EXACT [EC:2.7.1.28]
synonym: "trio triose kinase (phosphorylating)" EXACT [EC:2.7.1.28]
synonym: "triose kinase activity" EXACT [EC:2.7.1.28]
xref: EC:2.7.1.28
xref: MetaCyc:TRIOKINASE-RXN
xref: Reactome:70343 "triokinase activity"
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050355
name: triphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: triphosphate + H2O = diphosphate + phosphate." [EC:3.6.1.25, MetaCyc:TRIPHOSPHATASE-RXN]
subset: gosubset_prok
synonym: "inorganic triphosphatase activity" EXACT [EC:3.6.1.25]
synonym: "triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.25]
xref: EC:3.6.1.25
xref: MetaCyc:TRIPHOSPHATASE-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0050356
name: tropine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tropine + NADP+ = tropinone + NADPH." [EC:1.1.1.206, MetaCyc:TROPINE-DEHYDROGENASE-RXN]
synonym: "tropine:NADP+ 3alpha-oxidoreductase activity" EXACT [EC:1.1.1.206]
xref: EC:1.1.1.206
xref: MetaCyc:TROPINE-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050357
name: tropinesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: atropine + H2O = tropine + tropate." [EC:3.1.1.10, MetaCyc:TROPINESTERASE-RXN]
subset: gosubset_prok
synonym: "atropinase activity" EXACT [EC:3.1.1.10]
synonym: "atropine acylhydrolase activity" EXACT [EC:3.1.1.10]
synonym: "atropine esterase activity" EXACT [EC:3.1.1.10]
synonym: "atropinesterase activity" EXACT [EC:3.1.1.10]
synonym: "tropine esterase activity" EXACT [EC:3.1.1.10]
xref: EC:3.1.1.10
xref: MetaCyc:TROPINESTERASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050358
name: tropinone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: pseudotropine + NADP+ = tropinone + NADPH." [EC:1.1.1.236, MetaCyc:TROPINONE-REDUCTASE-RXN]
synonym: "pseudotropine forming tropinone reductase activity" EXACT [EC:1.1.1.236]
synonym: "pseudotropine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.236]
synonym: "tropinone (psi-tropine-forming) reductase activity" EXACT [EC:1.1.1.236]
synonym: "tropinone reductase II activity" RELATED [EC:1.1.1.236]
xref: EC:1.1.1.236
xref: MetaCyc:TROPINONE-REDUCTASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050359
name: tropomyosin kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin." [EC:2.7.11.28, MetaCyc:TROPOMYOSIN-KINASE-RXN]
synonym: "ATP:tropomyosin O-phosphotransferase activity" EXACT [EC:2.7.11.28]
synonym: "STK" RELATED [EC:2.7.11.28]
synonym: "tropomyosin kinase (phosphorylating) activity" EXACT [EC:2.7.11.28]
xref: EC:2.7.11.28
xref: MetaCyc:TROPOMYOSIN-KINASE-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0050360
name: tryptophan 2'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3." [EC:1.13.99.3, MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN]
synonym: "indole-3-alkane alpha-hydroxylase activity" EXACT [EC:1.13.99.3]
synonym: "indolyl-3-alkan alpha-hydroxylase activity" EXACT [EC:1.13.99.3]
synonym: "L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)" EXACT [EC:1.13.99.3]
synonym: "tryptophan side chain oxidase activity" EXACT [EC:1.13.99.3]
synonym: "tryptophan side chain oxidase II" RELATED [EC:1.13.99.3]
synonym: "tryptophan side chain oxidase type I" RELATED [EC:1.13.99.3]
synonym: "tryptophan side-chain alpha,beta-oxidase activity" RELATED [EC:1.13.99.3]
synonym: "tryptophan side-chain oxidase activity" RELATED [EC:1.13.99.3]
synonym: "TSO activity" RELATED [EC:1.13.99.3]
synonym: "TSO I" RELATED [EC:1.13.99.3]
synonym: "TSO II" RELATED [EC:1.13.99.3]
xref: EC:1.13.99.3
xref: MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN
is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen

[Term]
id: GO:0050361
name: tryptophan 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + O2 = indole-3-acetamide + CO2 + H2O." [EC:1.13.12.3, MetaCyc:TRYPTOPHAN-2-MONOOXYGENASE-RXN]
subset: gosubset_prok
synonym: "L-tryptophan:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.3]
xref: EC:1.13.12.3
xref: MetaCyc:TRYPTOPHAN-2-MONOOXYGENASE-RXN
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0050362
name: L-tryptophan:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate." [EC:2.6.1.27, MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN]
synonym: "5-hydroxytryptophan-ketoglutaric transaminase activity" RELATED [EC:2.6.1.27]
synonym: "hydroxytryptophan aminotransferase activity" RELATED [EC:2.6.1.27]
synonym: "L-phenylalanine-2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.27]
synonym: "L-tryptophan aminotransferase activity" BROAD [EC:2.6.1.27]
synonym: "L-tryptophan transaminase activity" BROAD [EC:2.6.1.27]
synonym: "tryptophan aminotransferase activity" EXACT []
synonym: "tryptophan transaminase activity" BROAD [EC:2.6.1.27]
xref: EC:2.6.1.27
xref: MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN
is_a: GO:0070529 ! L-tryptophan aminotransferase activity

[Term]
id: GO:0050363
name: tryptophan dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+." [EC:1.4.1.19, MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN]
synonym: "L-Trp-dehydrogenase activity" EXACT [EC:1.4.1.19]
synonym: "L-tryptophan dehydrogenase activity" EXACT [EC:1.4.1.19]
synonym: "L-tryptophan:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.19]
synonym: "NAD(P)+-L-tryptophan dehydrogenase activity" EXACT [EC:1.4.1.19]
synonym: "TDH" RELATED [EC:1.4.1.19]
synonym: "TrpDH activity" EXACT [EC:1.4.1.19]
xref: EC:1.4.1.19
xref: MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050364
name: tryptophan dimethylallyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan." [EC:2.5.1.34, MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN]
synonym: "4-(gamma,gamma-dimethylallyl)tryptophan synthase activity" EXACT [EC:2.5.1.34]
synonym: "dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase activity" EXACT [EC:2.5.1.34]
synonym: "dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase activity" EXACT [EC:2.5.1.34]
synonym: "dimethylallylpyrophosphate:tryptophan dimethylallyl transferase activity" EXACT [EC:2.5.1.34]
synonym: "dimethylallyltryptophan synthetase activity" EXACT [EC:2.5.1.34]
synonym: "DMAT synthetase activity" EXACT [EC:2.5.1.34]
xref: EC:2.5.1.34
xref: MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050365
name: tryptophanamidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophanamide + H2O = L-tryptophan + NH3." [EC:3.5.1.57, MetaCyc:TRYPTOPHANAMIDASE-RXN]
synonym: "L-tryptophan aminopeptidase" BROAD [EC:3.5.1.57]
synonym: "L-tryptophanamide amidohydrolase activity" EXACT [EC:3.5.1.57]
synonym: "tryptophan aminopeptidase" BROAD [EC:3.5.1.57]
xref: EC:3.5.1.57
xref: MetaCyc:TRYPTOPHANAMIDASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050366
name: tyramine N-feruloyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine." [EC:2.3.1.110, MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN]
synonym: "feruloyl-CoA tyramine N-feruloyl-CoA transferase activity" EXACT [EC:2.3.1.110]
synonym: "feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase activity" EXACT [EC:2.3.1.110]
synonym: "feruloyltyramine synthase activity" EXACT [EC:2.3.1.110]
synonym: "tyramine feruloyltransferase activity" EXACT [EC:2.3.1.110]
synonym: "tyramine N-feruloyl-CoA transferase activity" EXACT [EC:2.3.1.110]
xref: EC:2.3.1.110
xref: MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050367
name: tyrosine-arginine ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + L-tyrosine + L-arginine = AMP + diphosphate + L-tyrosyl-L-arginine." [EC:6.3.2.24, MetaCyc:TYROSINE--ARGININE-LIGASE-RXN]
synonym: "kyotorphin synthase activity" EXACT [EC:6.3.2.24]
synonym: "kyotorphin synthetase activity" EXACT [EC:6.3.2.24]
synonym: "kyotorphin-synthesizing enzyme activity" EXACT [EC:6.3.2.24]
synonym: "L-tyrosine:L-arginine ligase (AMP-forming)" EXACT [EC:6.3.2.24]
synonym: "tyrosyl-arginine synthase activity" EXACT [EC:6.3.2.24]
xref: EC:6.3.2.24
xref: MetaCyc:TYROSINE--ARGININE-LIGASE-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0050368
name: tyrosine 2,3-aminomutase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate." [EC:5.4.3.6, MetaCyc:TYROSINE-23-AMINOMUTASE-RXN]
synonym: "L-tyrosine 2,3-aminomutase activity" EXACT [EC:5.4.3.6]
synonym: "tyrosine alpha,beta-mutase activity" EXACT [EC:5.4.3.6]
xref: EC:5.4.3.6
xref: MetaCyc:TYROSINE-23-AMINOMUTASE-RXN
is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups

[Term]
id: GO:0050369
name: [tyrosine 3-monooxygenase] kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]." [EC:2.7.11.6, MetaCyc:TYROSINE-3-MONOOXYGENASE-KINASE-RXN]
synonym: "ATP:tyrosine-3-monoxygenase phosphotransferase activity" EXACT [EC:2.7.11.6]
synonym: "pheochromocytoma tyrosine hydroxylase-associated kinase activity" EXACT [EC:2.7.11.6]
synonym: "STK4" RELATED [EC:2.7.11.6]
synonym: "tyrosine 3-monooxygenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.6]
synonym: "tyrosine 3-monooxygenase kinase activity" EXACT []
xref: EC:2.7.11.6
xref: MetaCyc:2.7.11.6-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0050370
name: tyrosine N-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O." [EC:1.14.13.41, MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN]
synonym: "CYP79A1 activity" NARROW [EC:1.14.13.41]
synonym: "L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)" EXACT [EC:1.14.13.41]
synonym: "tyrosine N-hydroxylase activity" EXACT []
xref: EC:1.14.13.41
xref: MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050371
name: tyrosine phenol-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + H2O = phenol + pyruvate + NH3." [EC:4.1.99.2, MetaCyc:TYROSINE-PHENOL-LYASE-RXN]
subset: gosubset_prok
synonym: "beta-tyrosinase activity" EXACT [EC:4.1.99.2]
synonym: "L-tyrosine phenol-lyase (deaminating)" EXACT [EC:4.1.99.2]
synonym: "L-tyrosine phenol-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.1.99.2]
xref: EC:4.1.99.2
xref: MetaCyc:TYROSINE-PHENOL-LYASE-RXN
is_a: GO:0016830 ! carbon-carbon lyase activity

[Term]
id: GO:0050372
name: ubiquitin-calmodulin ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: n ATP + calmodulin + n ubiquitin = n AMP + n diphosphate + ubiquitin(n)-calmodulin." [EC:6.3.2.21, MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN]
synonym: "calmodulin:ubiquitin ligase (AMP-forming)" EXACT [EC:6.3.2.21]
synonym: "ubiquitin-calmodulin synthetase activity" EXACT [EC:6.3.2.21]
synonym: "ubiquityl-calmodulin synthase activity" EXACT [EC:6.3.2.21]
synonym: "ubiquityl-calmodulin synthetase activity" EXACT [EC:6.3.2.21]
synonym: "uCaM-synthetase activity" EXACT [EC:6.3.2.21]
xref: EC:6.3.2.21
xref: MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN
is_a: GO:0004842 ! ubiquitin-protein ligase activity

[Term]
id: GO:0050373
name: UDP-arabinose 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-L-arabinose = UDP-D-xylose." [EC:5.1.3.5, MetaCyc:UDP-ARABINOSE-4-EPIMERASE-RXN]
synonym: "UDP arabinose epimerase activity" EXACT [EC:5.1.3.5]
synonym: "UDP-D-xylose 4-epimerase activity" EXACT [EC:5.1.3.5]
synonym: "UDP-D-xylose-4-epimerase activity" EXACT []
synonym: "UDP-L-arabinose 4-epimerase activity" EXACT [EC:5.1.3.5]
synonym: "UDParabinose 4-epimerase activity" EXACT [EC:5.1.3.5]
synonym: "uridine 5'-diphosphate-D-xylose 4-epimerase activity" EXACT [EC:5.1.3.5]
synonym: "uridine diphosphoarabinose epimerase activity" EXACT [EC:5.1.3.5]
xref: EC:5.1.3.5
xref: MetaCyc:UDP-ARABINOSE-4-EPIMERASE-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050374
name: UDP-galacturonate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-galacturonate = UDP-L-arabinose + CO2." [EC:4.1.1.67, MetaCyc:UDP-GALACTURONATE-DECARBOXYLASE-RXN]
synonym: "UDP-D-galacturonate carboxy-lyase (UDP-L-arabinose-forming)" EXACT [EC:4.1.1.67]
synonym: "UDP-D-galacturonate carboxy-lyase activity" EXACT [EC:4.1.1.67]
synonym: "UDP-galacturonic acid decarboxylase activity" EXACT [EC:4.1.1.67]
synonym: "UDPgalacturonate decarboxylase activity" EXACT [EC:4.1.1.67]
synonym: "UDPGalUA carboxy lyase activity" EXACT [EC:4.1.1.67]
xref: EC:4.1.1.67
xref: MetaCyc:UDP-GALACTURONATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050376
name: UDP-glucosamine 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucosamine = UDPgalactosamine." [EC:5.1.3.16, MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN]
synonym: "UDP-glucosamine epimerase activity" EXACT []
synonym: "UDPglucosamine 4-epimerase activity" EXACT [EC:5.1.3.16]
xref: EC:5.1.3.16
xref: MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050377
name: UDP-glucose 4,6-dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose = UDP-4-dehydro-6-deoxy-D-glucose + H2O." [EC:4.2.1.76, MetaCyc:UDP-GLUCOSE-46-DEHYDRATASE-RXN]
synonym: "UDP-D-glucose oxidoreductase activity" EXACT [EC:4.2.1.76]
synonym: "UDP-D-glucose-4,6-hydrolyase activity" EXACT [EC:4.2.1.76]
synonym: "UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.76]
synonym: "UDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.76]
synonym: "UDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.76]
synonym: "UDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.76]
xref: EC:4.2.1.76
xref: MetaCyc:UDP-GLUCOSE-46-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050378
name: UDP-glucuronate 4-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucuronate = UDP-D-galacturonate." [EC:5.1.3.6, MetaCyc:UDP-GLUCURONATE-4-EPIMERASE-RXN]
synonym: "UDP glucuronic epimerase activity" EXACT [EC:5.1.3.6]
synonym: "UDP-D-galacturonic acid 4-epimerase activity" EXACT [EC:5.1.3.6]
synonym: "UDP-galacturonate 4-epimerase activity" EXACT [EC:5.1.3.6]
synonym: "UDPglucuronate 4-epimerase activity" EXACT [EC:5.1.3.6]
synonym: "uridine diphospho-D-galacturonic acid" RELATED [EC:5.1.3.6]
synonym: "uridine diphosphoglucuronate epimerase activity" EXACT [EC:5.1.3.6]
synonym: "uridine diphosphoglucuronic epimerase activity" EXACT [EC:5.1.3.6]
xref: EC:5.1.3.6
xref: MetaCyc:PWY-4861
xref: MetaCyc:UDP-GLUCURONATE-4-EPIMERASE-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050379
name: UDP-glucuronate 5'-epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucuronate = UDP-L-iduronate." [EC:5.1.3.12, MetaCyc:UDP-GLUCURONATE-5-EPIMERASE-RXN]
subset: gosubset_prok
synonym: "C-5-uronosyl epimerase activity" EXACT [EC:5.1.3.12]
synonym: "UDP-glucuronate 5' epimerase activity" EXACT []
synonym: "UDP-glucuronic acid 5'-epimerase activity" EXACT [EC:5.1.3.12]
synonym: "UDP-glucuronic acid epimerase activity" EXACT [EC:5.1.3.12]
synonym: "UDPglucuronate 5'-epimerase activity" EXACT [EC:5.1.3.12]
synonym: "uridine diphosphoglucuronate 5'-epimerase activity" EXACT [EC:5.1.3.12]
xref: EC:5.1.3.12
xref: MetaCyc:UDP-GLUCURONATE-5-EPIMERASE-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050380
name: undecaprenyl-diphosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate." [EC:3.6.1.27, MetaCyc:UNDECAPRENYL-DIPHOSPHATASE-RXN]
subset: gosubset_prok
synonym: "C(55)-isoprenyl diphosphatase activity" EXACT [EC:3.6.1.27]
synonym: "C(55)-isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27]
synonym: "C55-isoprenyl diphosphatase activity" EXACT [EC:3.6.1.27]
synonym: "C55-isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27]
synonym: "isoprenyl pyrophosphatase activity" EXACT [EC:3.6.1.27]
synonym: "undecaprenyl-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.27]
xref: EC:3.6.1.27
xref: MetaCyc:UNDECAPRENYL-DIPHOSPHATASE-RXN
is_a: GO:0016462 ! pyrophosphatase activity

[Term]
id: GO:0050382
name: uracil-5-carboxylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: uracil 5-carboxylate = uracil + CO2." [EC:4.1.1.66, MetaCyc:URACIL-5-CARBOXYLATE-DECARBOXYLASE-RXN]
synonym: "uracil-5-carboxylate carboxy-lyase (uracil-forming)" EXACT [EC:4.1.1.66]
synonym: "uracil-5-carboxylate carboxy-lyase activity" EXACT [EC:4.1.1.66]
synonym: "uracil-5-carboxylic acid decarboxylase activity" EXACT [EC:4.1.1.66]
xref: EC:4.1.1.66
xref: MetaCyc:URACIL-5-CARBOXYLATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050383
name: uracil dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor." [EC:1.1.99.19, MetaCyc:URACIL-DEHYDROGENASE-RXN]
xref: EC:1.1.99.19
xref: MetaCyc:URACIL-DEHYDROGENASE-RXN
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0050384
name: urate-ribonucleotide phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: urate D-ribonucleotide + phosphate = urate + D-ribose 1-phosphate." [EC:2.4.2.16, MetaCyc:URATE-RIBONUCLEOTIDE-PHOSPHORYLASE-RXN]
synonym: "UAR phosphorylase activity" EXACT [EC:2.4.2.16]
synonym: "urate-ribonucleotide:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.16]
synonym: "urate-ribonucleotide:phosphate D-ribosyltransferase activity" EXACT [EC:2.4.2.16]
xref: EC:2.4.2.16
xref: MetaCyc:URATE-RIBONUCLEOTIDE-PHOSPHORYLASE-RXN
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0050385
name: ureidoglycolate lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (-)-ureidoglycolate = glyoxylate + urea." [EC:4.3.2.3, MetaCyc:UREIDOGLYCOLATE-LYASE-RXN]
synonym: "(S)-ureidoglycolate urea-lyase (glyoxylate-forming)" EXACT [EC:4.3.2.3]
synonym: "(S)-ureidoglycolate urea-lyase activity" EXACT [EC:4.3.2.3]
synonym: "ureidoglycolase activity" RELATED [EC:4.3.2.3]
synonym: "ureidoglycolatase activity" RELATED [EC:4.3.2.3]
xref: EC:4.3.2.3
xref: MetaCyc:UREIDOGLYCOLATE-LYASE-RXN
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0050386
name: ureidosuccinase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-carbamoyl-L-aspartate + H2O = L-aspartate + CO2 + NH3." [EC:3.5.1.7, MetaCyc:UREIDOSUCCINASE-RXN]
synonym: "N-carbamoyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.7]
xref: EC:3.5.1.7
xref: MetaCyc:UREIDOSUCCINASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050387
name: urethanase activity
namespace: molecular_function
def: "Catalysis of the reaction: urethane + H2O = ethanol + CO2 + NH3." [EC:3.5.1.75, MetaCyc:URETHANASE-RXN]
synonym: "urethane amidohydrolase (decarboxylating)" EXACT [EC:3.5.1.75]
synonym: "urethane hydrolase activity" EXACT [EC:3.5.1.75]
xref: EC:3.5.1.75
xref: MetaCyc:URETHANASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050388
name: uronate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galacturonate + NAD+ + H2O = D-galactarate + NADH." [EC:1.1.1.203, MetaCyc:URONATE-DEHYDROGENASE-RXN]
synonym: "uronate: NAD-oxidoreductase activity" EXACT [EC:1.1.1.203]
synonym: "uronate:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.203]
synonym: "uronic acid dehydrogenase activity" EXACT [EC:1.1.1.203]
xref: EC:1.1.1.203
xref: MetaCyc:URONATE-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050389
name: uronolactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate." [EC:3.1.1.19, MetaCyc:URONOLACTONASE-RXN]
synonym: "D-glucurono-6,2-lactone lactonohydrolase activity" EXACT [EC:3.1.1.19]
synonym: "glucuronolactonase activity" EXACT [EC:3.1.1.19]
xref: EC:3.1.1.19
xref: MetaCyc:URONOLACTONASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050390
name: valine decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-valine = 2-methylpropanamine + CO2." [EC:4.1.1.14, MetaCyc:VALINE-DECARBOXYLASE-RXN]
synonym: "L-valine carboxy-lyase (2-methylpropanamine-forming)" EXACT [EC:4.1.1.14]
synonym: "L-valine carboxy-lyase activity" EXACT [EC:4.1.1.14]
synonym: "l-valine carboxy-lyase activity" EXACT [EC:4.1.1.14]
synonym: "leucine decarboxylase activity" EXACT [EC:4.1.1.14]
xref: EC:4.1.1.14
xref: MetaCyc:VALINE-DECARBOXYLASE-RXN
xref: UM-BBD_enzymeID:e0655
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050391
name: valine dehydrogenase (NADP) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH." [EC:1.4.1.8, MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN]
synonym: "L-valine:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.8]
synonym: "valine dehydrogenase (NADP+) activity" EXACT []
synonym: "valine dehydrogenase (nicotinanide adenine dinucleotide phosphate)" EXACT [EC:1.4.1.8]
xref: EC:1.4.1.8
xref: MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN
is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050392
name: vicianin beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-vicianin + H2O = mandelonitrile + vicianose." [EC:3.2.1.119, MetaCyc:VICIANIN-BETA-GLUCOSIDASE-RXN]
synonym: "(R)-vicianin beta-D-glucohydrolase activity" EXACT [EC:3.2.1.119]
synonym: "vicianin b-glucosidase activity" EXACT []
synonym: "vicianin hydrolase activity" EXACT [EC:3.2.1.119]
xref: EC:3.2.1.119
xref: MetaCyc:VICIANIN-BETA-GLUCOSIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0050393
name: vinylacetyl-CoA delta-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: vinylacetyl-CoA = crotonyl-CoA." [EC:5.3.3.3, MetaCyc:VINYLACETYL-COA-DELTA-ISOMERASE-RXN]
subset: gosubset_prok
synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.3]
synonym: "vinylacetyl coenzyme A delta-isomerase activity" EXACT [EC:5.3.3.3]
synonym: "vinylacetyl coenzyme A isomerase activity" EXACT [EC:5.3.3.3]
synonym: "vinylacetyl-CoA D-isomerase activity" EXACT []
synonym: "vinylacetyl-CoA delta3-delta2-isomerase activity" EXACT [EC:5.3.3.3]
xref: EC:5.3.3.3
xref: MetaCyc:VINYLACETYL-COA-DELTA-ISOMERASE-RXN
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0050394
name: viomycin kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + viomycin = ADP + O-phosphoviomycin." [EC:2.7.1.103, MetaCyc:VIOMYCIN-KINASE-RXN]
subset: gosubset_prok
synonym: "ATP:viomycin O-phosphotransferase activity" EXACT [EC:2.7.1.103]
synonym: "capreomycin phosphotransferase activity" EXACT [EC:2.7.1.103]
synonym: "viomycin phosphotransferase activity" EXACT [EC:2.7.1.103]
xref: EC:2.7.1.103
xref: MetaCyc:VIOMYCIN-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050395
name: vitexin beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: vitexin + UDP-D-glucose = vitexin 2'-O-beta-D-glucoside + UDP." [EC:2.4.1.105, MetaCyc:VITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN]
synonym: "UDP-glucose:vitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.105]
synonym: "UDPglucose:vitexin 2''-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.105]
synonym: "uridine diphosphoglucose-vitexin 2''-glucosyltransferase activity" EXACT [EC:2.4.1.105]
synonym: "vitexin b-glucosyltransferase activity" EXACT []
xref: EC:2.4.1.105
xref: MetaCyc:VITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050396
name: vomifoliol 4'-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + (+-)-6-hydroxy-3-oxo-alpha-ionol = NADH + (+-)-6-hydroxy-3-oxo-alpha-ionone." [EC:1.1.1.221, MetaCyc:VOMIFOLIOL-4-DEHYDROGENASE-RXN]
synonym: "vomifoliol:NAD+ 4'-oxidoreductase activity" EXACT [EC:1.1.1.221]
xref: EC:1.1.1.221
xref: MetaCyc:VOMIFOLIOL-4-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050397
name: Watasenia-luciferin 2-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light." [EC:1.13.12.8, MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN]
synonym: "luciferase activity" BROAD [EC:1.13.12.8]
synonym: "Watasenia-luciferin:oxygen 2-oxidoreductase (decarboxylating)" EXACT [EC:1.13.12.8]
synonym: "Watasenia-type luciferase activity" EXACT [EC:1.13.12.8]
synonym: "watasenia-type luciferase activity" EXACT [EC:1.13.12.8]
xref: EC:1.13.12.8
xref: MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
is_a: GO:0045289 ! luciferin monooxygenase activity

[Term]
id: GO:0050398
name: wax-ester hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate." [EC:3.1.1.50, MetaCyc:WAX-ESTER-HYDROLASE-RXN]
synonym: "jojoba wax esterase" NARROW [EC:3.1.1.50]
synonym: "wax-ester acylhydrolase activity" EXACT [EC:3.1.1.50]
synonym: "WEH" RELATED [EC:3.1.1.50]
xref: EC:3.1.1.50
xref: MetaCyc:WAX-ESTER-HYDROLASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050399
name: xanthommatin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD+ = xanthommatin + NADH." [EC:1.3.1.41, MetaCyc:XANTHOMMATIN-REDUCTASE-RXN]
synonym: "5,12-dihydroxanthommatin:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.41]
xref: EC:1.3.1.41
xref: MetaCyc:XANTHOMMATIN-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050400
name: xylitol kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + xylitol = ADP + xylitol 5-phosphate." [EC:2.7.1.122, MetaCyc:XYLITOL-KINASE-RXN]
synonym: "ATP:xylitol 5-phosphotransferase activity" EXACT [EC:2.7.1.122]
synonym: "xylitol phosphotransferase activity" EXACT [EC:2.7.1.122]
xref: EC:2.7.1.122
xref: MetaCyc:XYLITOL-KINASE-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050401
name: xylonate dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-xylonate + H2O." [EC:4.2.1.82, MetaCyc:XYLONATE-DEHYDRATASE-RXN]
synonym: "D-xylo-aldonate dehydratase activity" EXACT [EC:4.2.1.82]
synonym: "D-xylonate dehydratase activity" EXACT [EC:4.2.1.82]
synonym: "D-xylonate hydro-lyase (2-dehydro-3-deoxy-D-xylonate-forming)" EXACT [EC:4.2.1.82]
synonym: "D-xylonate hydro-lyase activity" EXACT [EC:4.2.1.82]
xref: EC:4.2.1.82
xref: MetaCyc:XYLONATE-DEHYDRATASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050402
name: xylono-1,4-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate." [EC:3.1.1.68, MetaCyc:XYLONO-14-LACTONASE-RXN]
synonym: "D-xylono-1,4-lactone lactonohydrolase activity" EXACT [EC:3.1.1.68]
synonym: "xylono-g-lactonase activity" EXACT [EC:3.1.1.68]
synonym: "xylonolactonase activity" EXACT [EC:3.1.1.68]
xref: EC:3.1.1.68
xref: MetaCyc:XYLONO-14-LACTONASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050403
name: trans-zeatin O-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + trans-zeatin = UDP + O-beta-D-glucosyl-trans-zeatin." [EC:2.4.1.203, MetaCyc:ZEATIN-O-BETA-D-GLUCOSYLTRANSFERASE-RXN]
synonym: "UDP-glucose:trans-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203]
synonym: "UDPglucose:trans-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203]
synonym: "uridine diphosphoglucose-zeatin O-glucosyltransferase activity" EXACT [EC:2.4.1.203]
synonym: "zeatin O-b-D-glucosyltransferase activity" EXACT []
synonym: "zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.203]
synonym: "zeatin O-glucosyltransferase activity" EXACT [EC:2.4.1.203]
xref: EC:2.4.1.203
xref: MetaCyc:RXN-4723
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050404
name: zeatin O-beta-D-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-xylose + zeatin = UDP + O-beta-D-xylosylzeatin." [EC:2.4.1.204, MetaCyc:ZEATIN-O-BETA-D-XYLOSYLTRANSFERASE-RXN]
comment: Note that this function was formerly EC:2.4.1.204.
synonym: "UDP-D-xylose:zeatin O-beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.40]
synonym: "uridine diphosphoxylose-zeatin xylosyltransferase activity" EXACT [EC:2.4.2.40]
synonym: "zeatin O-b-D-xylosyltransferase activity" EXACT []
synonym: "zeatin O-xylosyltransferase activity" EXACT [EC:2.4.2.40]
xref: EC:2.4.2.40
xref: MetaCyc:ZEATIN-O-BETA-D-XYLOSYLTRANSFERASE-RXN
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0050405
name: [acetyl-CoA carboxylase] kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate." [EC:2.7.11.27, MetaCyc:[ACETYL-COA-CARBOXYLASE\]-KINASE-RXN]
synonym: "acetyl coenzyme A carboxylase kinase (phosphorylating) activity" EXACT [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase bound kinase activity" NARROW [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase (AMP-activated) activity" EXACT [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase (cAMP-independent) activity" EXACT [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase 2 activity" NARROW [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase activity" EXACT [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase-2 activity" NARROW [EC:2.7.11.27]
synonym: "acetyl-CoA carboxylase kinase-3 (AMP-activated) activity" NARROW [EC:2.7.11.27]
synonym: "acetyl-coenzyme A carboxylase kinase activity" EXACT [EC:2.7.11.27]
synonym: "ACK2" RELATED [EC:2.7.11.27]
synonym: "ACK3" RELATED [EC:2.7.11.27]
synonym: "AMPK" RELATED [EC:2.7.11.27]
synonym: "ATP:acetyl-CoA carboxylase phosphotransferase activity" EXACT [EC:2.7.11.27]
synonym: "I-peptide kinase activity" NARROW [EC:2.7.11.27]
synonym: "STK5" RELATED [EC:2.7.11.27]
xref: EC:2.7.11.27
xref: MetaCyc:2.7.11.27-RXN
is_a: GO:0004672 ! protein kinase activity

[Term]
id: GO:0050406
name: [acetyl-CoA carboxylase]-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate." [EC:3.1.3.44, MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN]
synonym: "acetyl-CoA carboxylase-phosphatase activity" EXACT [EC:3.1.3.44]
synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.44]
xref: EC:3.1.3.44
xref: MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050407
name: [glycogen-synthase-D] phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate." [EC:3.1.3.42, MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN]
synonym: "glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42]
synonym: "glycogen synthase D phosphatase activity" EXACT [EC:3.1.3.42]
synonym: "glycogen synthase phosphatase activity" EXACT [EC:3.1.3.42]
synonym: "glycogen synthetase phosphatase activity" EXACT [EC:3.1.3.42]
synonym: "glycogen-synthase-D phosphatase activity" EXACT [EC:3.1.3.42]
synonym: "Mg2+ dependent glycogen synthase phosphatase activity" EXACT [EC:3.1.3.42]
synonym: "phosphatase type 2oC" RELATED [EC:3.1.3.42]
synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity" EXACT [EC:3.1.3.42]
synonym: "UDP-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42]
synonym: "UDPglucose-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42]
synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity" EXACT [EC:3.1.3.42]
synonym: "uridine diphosphoglucose-glycogen glucosyltransferase phosphatase activity" EXACT [EC:3.1.3.42]
xref: EC:3.1.3.42
xref: MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050408
name: [pyruvate kinase]-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate." [EC:3.1.3.49, MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN]
synonym: "ATP:pyruvate 2-O-phosphotransferase-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.49]
synonym: "pyruvate kinase phosphatase activity" EXACT [EC:3.1.3.49]
synonym: "pyruvate kinase-phosphatase activity" EXACT [EC:3.1.3.49]
xref: EC:3.1.3.49
xref: MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050409
name: indolylacetylinositol arabinosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-L-arabinose + indol-3-ylacetyl-myo-inositol = UDP + indol-3-ylacetyl-myo-inositol L-arabinoside." [EC:2.4.2.34, MetaCyc:2.4.2.34-RXN]
subset: gosubset_prok
synonym: "arabinosylindolylacetylinositol synthase activity" EXACT [EC:2.4.2.34]
synonym: "UDP-L-arabinose:(indol-3-yl)acetyl-myo-inositol L-arabinosyltransferase activity" EXACT [EC:2.4.2.34]
synonym: "UDP-L-arabinose:indol-3-ylacetyl-myo-inositol L-arabinosyltransferase activity" EXACT [EC:2.4.2.34]
xref: EC:2.4.2.34
xref: MetaCyc:2.4.2.34-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0050410
name: 3-oxolaurate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-oxododecanoate = 2-undecanone + CO2." [EC:4.1.1.56, MetaCyc:3-OXOLAURATE-DECARBOXYLASE-RXN]
synonym: "3-oxododecanoate carboxy-lyase (2-undecanone-forming)" EXACT [EC:4.1.1.56]
synonym: "3-oxododecanoate carboxy-lyase activity" EXACT [EC:4.1.1.56]
synonym: "beta-ketoacyl decarboxylase activity" EXACT [EC:4.1.1.56]
synonym: "beta-ketolaurate decarboxylase activity" EXACT [EC:4.1.1.56]
xref: EC:4.1.1.56
xref: MetaCyc:3-OXOLAURATE-DECARBOXYLASE-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050411
name: agaritine gamma-glutamyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: agaritine + acceptor-NH2 = 4-hydroxymethylphenylhydrazine + gamma-L-glutamyl-acceptor." [EC:2.3.2.9, MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN]
synonym: "(gamma-L-glutamyl)-1-N-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity" EXACT [EC:2.3.2.9]
synonym: "(gamma-L-glutamyl)-N1-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity" EXACT [EC:2.3.2.9]
synonym: "agaritine g-glutamyltransferase activity" EXACT []
xref: EC:2.3.2.9
xref: MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN
is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups

[Term]
id: GO:0050412
name: cinnamate beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + trans-cinnamate = UDP + trans-cinnamoyl beta-D-glucoside." [EC:2.4.1.177, MetaCyc:CINNAMATE-GLUCOSYLTRANSFERASE-RXN]
synonym: "cinnamate b-D-glucosyltransferase activity" EXACT []
synonym: "cinnamate glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:trans-cinnamate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.177]
synonym: "UDPG:t-cinnamate glucosyltransferase activity" EXACT [EC:2.4.1.177]
synonym: "UDPglucose:trans-cinnamate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.177]
synonym: "uridine diphosphoglucose-cinnamate glucosyltransferase activity" EXACT [EC:2.4.1.177]
xref: EC:2.4.1.177
xref: MetaCyc:CINNAMATE-GLUCOSYLTRANSFERASE-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050413
name: D-alanine 2-hydroxymethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H2O = tetrahydrofolate + 2-methylserine." [EC:2.1.2.7, MetaCyc:D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN]
synonym: "2-methylserine hydroxymethyltransferase activity" EXACT [EC:2.1.2.7]
synonym: "5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase activity" EXACT [EC:2.1.2.7]
synonym: "D-alanine hydroxymethyltransferase activity" EXACT []
xref: EC:2.1.2.7
xref: MetaCyc:D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN
is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity

[Term]
id: GO:0050414
name: formimidoylaspartate deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3." [EC:3.5.3.5, MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN]
synonym: "formiminoaspartate deiminase activity" EXACT []
synonym: "N-formimidoyl-L-aspartate iminohydrolase activity" EXACT [EC:3.5.3.5]
xref: EC:3.5.3.5
xref: MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0050415
name: formimidoylglutamase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide." [EC:3.5.3.8, MetaCyc:FORMIMINOGLUTAMASE-RXN]
subset: gosubset_prok
synonym: "formiminoglutamase activity" EXACT []
synonym: "formiminoglutamate hydrolase activity" EXACT [EC:3.5.3.8]
synonym: "N-formimidoyl-L-glutamate formimidoylhydrolase activity" EXACT [EC:3.5.3.8]
synonym: "N-formimino-L-glutamate formiminohydrolase activity" EXACT [EC:3.5.3.8]
synonym: "N-formiminoglutamate hydrolase activity" EXACT [EC:3.5.3.8]
xref: EC:3.5.3.8
xref: MetaCyc:FORMIMINOGLUTAMASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0050416
name: formimidoylglutamate deiminase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3." [EC:3.5.3.13, MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN]
subset: gosubset_prok
synonym: "formiminoglutamate deiminase activity" EXACT []
synonym: "formiminoglutamic iminohydrolase activity" EXACT [EC:3.5.3.13]
synonym: "N-formimidoyl-L-glutamate iminohydrolase activity" EXACT [EC:3.5.3.13]
xref: EC:3.5.3.13
xref: MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0050417
name: glutamin-(asparagin-)ase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + L-glutamine (or L-asparagine) = NH3 + L-glutamate (or L-aspartate)." [EC:3.5.1.38, MetaCyc:GLUTAMINASE-ASPARAGIN-ASE-RXN]
subset: gosubset_prok
synonym: "glutaminase-(asparagin-)ase activity" EXACT []
synonym: "glutaminase-asparaginase activity" EXACT [EC:3.5.1.38]
synonym: "L-ASNase/L-GLNase activity" EXACT [EC:3.5.1.38]
synonym: "L-asparagine/L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.38]
synonym: "L-glutamine(L-asparagine) amidohydrolase activity" EXACT [EC:3.5.1.38]
xref: EC:3.5.1.38
xref: MetaCyc:GLUTAMINASE-ASPARAGIN-ASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050418
name: hydroxylamine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor." [EC:1.7.99.1, MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN]
subset: gosubset_prok
synonym: "ammonia:(acceptor) oxidoreductase activity" EXACT [EC:1.7.99.1]
synonym: "ammonia:acceptor oxidoreductase activity" EXACT [EC:1.7.99.1]
synonym: "hydroxylamine (acceptor) reductase activity" EXACT [EC:1.7.99.1]
xref: EC:1.7.99.1
xref: MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN
is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors

[Term]
id: GO:0050419
name: hydroxymandelonitrile lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate." [EC:4.1.2.11, MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN]
synonym: "(S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming)" EXACT [EC:4.1.2.11]
synonym: "(S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase activity" EXACT [EC:4.1.2.11]
synonym: "hydroxynitrile lyase activity" BROAD [EC:4.1.2.11]
synonym: "sorghum hydroxynitrile lyase activity" EXACT [EC:4.1.2.11]
xref: EC:4.1.2.11
xref: MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN
is_a: GO:0047606 ! hydroxynitrilase activity

[Term]
id: GO:0050420
name: maltose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate." [EC:2.4.1.139, MetaCyc:MALTOSE-SYNTHASE-RXN]
synonym: "alpha-D-glucose-1-phosphate:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (dephosphorylating)" EXACT [EC:2.4.1.139]
xref: EC:2.4.1.139
xref: MetaCyc:MALTOSE-SYNTHASE-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0050421
name: nitrite reductase (NO-forming) activity
namespace: molecular_function
alt_id: GO:0016666
def: "Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = NO2(-) (nitrite) + ferrocytochrome c + 2 H+." [EC:1.7.2.1, MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN]
comment: Note that EC:1.7.99.3 was merged into this term.
subset: gosubset_prok
synonym: "[nitrite reductase (cytochrome)]" RELATED [EC:1.7.2.1]
synonym: "cd-cytochrome nitrite reductase activity" NARROW [EC:1.7.2.1]
synonym: "cytochrome c-551:O(2), NO(2)(+) oxidoreductase activity" NARROW [EC:1.7.2.1]
synonym: "cytochrome c-551:O2, NO2+ oxidoreductase activity" EXACT [EC:1.7.2.1]
synonym: "cytochrome cd activity" NARROW [EC:1.7.2.1]
synonym: "cytochrome cd1 activity" NARROW [EC:1.7.2.1]
synonym: "methyl viologen-nitrite reductase activity" NARROW [EC:1.7.2.1]
synonym: "nitric-oxide:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.7.2.1]
synonym: "nitrite reductase (cytochrome) activity" EXACT []
synonym: "nitrite reductase (cytochrome; NO-forming) activity" EXACT [EC:1.7.2.1]
synonym: "nitrite reductase activity" EXACT []
synonym: "Pseudomonas cytochrome oxidase activity" NARROW [EC:1.7.2.1]
xref: EC:1.7.2.1
xref: MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor

[Term]
id: GO:0050422
name: strictosidine beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + strictosidine = D-glucose + strictosidine aglycone." [EC:3.2.1.105, MetaCyc:STRICTOSIDINE-BETA-GLUCOSIDASE-RXN]
synonym: "strictosidine b-glucosidase activity" EXACT []
synonym: "strictosidine beta-D-glucohydrolase activity" EXACT [EC:3.2.1.105]
xref: EC:3.2.1.105
xref: MetaCyc:STRICTOSIDINE-BETA-GLUCOSIDASE-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0050423
name: thiamin oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiamin + 2 O2 = thiamin acetic acid + 2 H2O2." [EC:1.1.3.23, MetaCyc:THIAMIN-OXIDASE-RXN]
synonym: "thiamin dehydrogenase activity" EXACT [EC:1.1.3.23]
synonym: "thiamin:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.23]
synonym: "thiamine dehydrogenase activity" EXACT [EC:1.1.3.23]
synonym: "thiamine oxidase activity" EXACT []
synonym: "thiamine:oxygen 5-oxidoreductase activity" EXACT [EC:1.1.3.23]
xref: EC:1.1.3.23
xref: MetaCyc:THIAMIN-OXIDASE-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050424
name: alanine carboxypeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups." [EC:3.4.17.6, MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "N-benzoyl-L-alanine-amidohydrolase activity" EXACT [EC:3.4.17.6]
xref: EC:3.4.17.6
xref: MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0050425
name: carboxypeptidase B activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid." [EC:3.4.17.2, MetaCyc:CARBOXYPEPTIDASE-B-RXN]
comment: This term was made obsolete because it represents a gene product.
subset: gosubset_prok
synonym: "pancreatic carboxypeptidase B" RELATED [EC:3.4.17.2]
synonym: "peptidyl-L-lysine [L-arginine]hydrolase activity" EXACT [EC:3.4.17.2]
synonym: "protaminase activity" RELATED [EC:3.4.17.2]
synonym: "tissue carboxypeptidase B" RELATED [EC:3.4.17.2]
xref: EC:3.4.17.2
xref: MetaCyc:CARBOXYPEPTIDASE-B-RXN
is_obsolete: true
replaced_by: GO:0004181

[Term]
id: GO:0050426
name: peptidyl-glycinamidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide." [EC:3.4.19.2, MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN]
comment: This term was made obsolete because it represents a gene product.
synonym: "carboxamidopeptidase activity" EXACT [EC:3.4.19.2]
synonym: "carboxyamidase activity" EXACT [EC:3.4.19.2]
synonym: "peptidyl amino acid amide hydrolase activity" EXACT [EC:3.4.19.2]
synonym: "peptidyl carboxy-amidase activity" EXACT [EC:3.4.19.2]
synonym: "peptidyl carboxyamidase activity" EXACT [EC:3.4.19.2]
xref: EC:3.4.19.2
xref: MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN
is_obsolete: true
replaced_by: GO:0008242

[Term]
id: GO:0050427
name: 3'-phosphoadenosine 5'-phosphosulfate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "3'-phosphoadenosine 5'-phosphosulfate metabolism" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulphate metabolic process" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulphate metabolism" EXACT []
synonym: "3'-phosphoadenylyl-sulfate metabolic process" EXACT []
synonym: "3'-phosphoadenylyl-sulfate metabolism" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate metabolic process" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate metabolism" EXACT []
synonym: "PAPS metabolic process" EXACT []
synonym: "PAPS metabolism" EXACT []
synonym: "phosphoadenosine phosphosulfate metabolic process" EXACT []
synonym: "phosphoadenosine phosphosulfate metabolism" EXACT []
xref: MetaCyc:PWY-5340
xref: Reactome:156584 "Cytosolic sulfonation of small molecules"
xref: Reactome:176606 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate"
xref: Reactome:430099 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate"
xref: Reactome:448573 "Cytosolic sulfonation of small molecules"
xref: Reactome:452303 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate"
xref: Reactome:469702 "Cytosolic sulfonation of small molecules"
xref: Reactome:472886 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate"
xref: Reactome:487414 "Cytosolic sulfonation of small molecules"
xref: Reactome:491206 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate"
xref: Reactome:507369 "Cytosolic sulfonation of small molecules"
xref: Reactome:509636 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate"
xref: Reactome:517377 "Cytosolic sulfonation of small molecules"
xref: Reactome:519394 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate"
xref: Reactome:526253 "Cytosolic sulfonation of small molecules"
xref: Reactome:553486 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate"
xref: Reactome:557760 "Cytosolic sulfonation of small molecules"
xref: Reactome:568373 "Cytosolic sulfonation of small molecules"
xref: Reactome:581575 "Cytosolic sulfonation of small molecules"
xref: Reactome:582316 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate"
xref: Reactome:587353 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate"
xref: Reactome:602453 "Cytosolic sulfonation of small molecules"
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process

[Term]
id: GO:0050428
name: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "3'-phosphoadenosine 5'-phosphosulfate anabolism" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulfate biosynthesis" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulfate formation" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulfate synthesis" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulphate biosynthesis" EXACT []
synonym: "3'-phosphoadenosine 5'-phosphosulphate biosynthetic process" EXACT []
synonym: "3'-phosphoadenylyl-sulfate biosynthesis" EXACT []
synonym: "3'-phosphoadenylyl-sulfate biosynthetic process" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate biosynthesis" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate biosynthetic process" EXACT []
synonym: "PAPS biosynthesis" EXACT []
synonym: "PAPS biosynthetic process" EXACT []
synonym: "phosphoadenosine phosphosulfate biosynthesis" EXACT []
synonym: "phosphoadenosine phosphosulfate biosynthetic process" EXACT []
xref: Reactome:174362 "Formation of PAPS"
xref: Reactome:448764 "Formation of PAPS"
xref: Reactome:469879 "Formation of PAPS"
xref: Reactome:487581 "Formation of PAPS"
xref: Reactome:507539 "Formation of PAPS"
xref: Reactome:517522 "Formation of PAPS"
xref: Reactome:526391 "Formation of PAPS"
xref: Reactome:531202 "Formation of PAPS"
xref: Reactome:536577 "Formation of PAPS"
xref: Reactome:542303 "Formation of PAPS"
xref: Reactome:547644 "Formation of PAPS"
xref: Reactome:552236 "Formation of PAPS"
xref: Reactome:557849 "Formation of PAPS"
xref: Reactome:568443 "Formation of PAPS"
xref: Reactome:581656 "Formation of PAPS"
xref: Reactome:585809 "Formation of PAPS"
xref: Reactome:599692 "Formation of PAPS"
xref: Reactome:600599 "Formation of PAPS"
xref: Reactome:602500 "Formation of PAPS"
is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process
is_a: GO:0050427 ! 3'-phosphoadenosine 5'-phosphosulfate metabolic process

[Term]
id: GO:0050429
name: calcium-dependent phospholipase C activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate; requires Ca2+." [EC:3.1.4.3]
is_a: GO:0004629 ! phospholipase C activity

[Term]
id: GO:0050430
name: syntaxin-6 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-6." [GOC:ai]
is_a: GO:0019905 ! syntaxin binding

[Term]
id: GO:0050431
name: transforming growth factor beta binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "TGF-beta binding" EXACT []
synonym: "TGFbeta binding" EXACT []
synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED []
synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED []
is_a: GO:0019838 ! growth factor binding
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0050432
name: catecholamine secretion
namespace: biological_process
def: "The regulated release of catecholamines by a cell or group of cells. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, GOC:ef]
is_a: GO:0032940 ! secretion by cell
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0050433
name: regulation of catecholamine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines." [GOC:ai]
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051952 ! regulation of amine transport
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0050432 ! catecholamine secretion

[Term]
id: GO:0050434
name: positive regulation of viral transcription
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of viral transcription." [GOC:ai]
synonym: "activation of viral transcription" NARROW []
synonym: "stimulation of viral transcription" NARROW []
synonym: "up regulation of viral transcription" EXACT []
synonym: "up-regulation of viral transcription" EXACT []
synonym: "upregulation of viral transcription" EXACT []
xref: Reactome:167246 "Tat-mediated elongation of the HIV-1 transcript"
is_a: GO:0045941 ! positive regulation of transcription
is_a: GO:0046782 ! regulation of viral transcription
is_a: GO:0048524 ! positive regulation of viral reproduction
relationship: positively_regulates GO:0019083 ! viral transcription

[Term]
id: GO:0050435
name: beta-amyloid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-amyloid, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP)." [GOC:ai]
subset: gosubset_prok
synonym: "beta-amyloid metabolism" EXACT []
is_a: GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:0050436
name: microfibril binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a microfibril, any small fibril occurring in biological material." [GOC:ai]
comment: See also the cellular component term 'microfibril ; GO:0001527'.
is_a: GO:0005488 ! binding

[Term]
id: GO:0050437
name: (-)-endo-fenchol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + geranyl-PP = pyrophosphate + (-)-endo-fenchol." [EC:4.2.3.10, MetaCyc:4.2.3.10-RXN]
synonym: "(-)-endo-fenchol cyclase activity" EXACT [EC:4.2.3.10]
synonym: "geranyl pyrophosphate:(-)-endo-fenchol cyclase activity" EXACT [EC:4.2.3.10]
synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]" RELATED [EC:4.2.3.10]
xref: EC:4.2.3.10
xref: MetaCyc:4.2.3.10-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050438
name: 2-ethylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + H2O + 2-oxobutanoate = (R)-2-ethylmalate + CoA ." [EC:2.3.3.6, MetaCyc:2-ETHYLMALATE-SYNTHASE-RXN]
synonym: "(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.6]
synonym: "2-ethylmalate-3-hydroxybutanedioate synthase activity" EXACT [EC:2.3.3.6]
synonym: "acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.6]
synonym: "propylmalate synthase activity" EXACT [EC:2.3.3.6]
synonym: "propylmalic synthase activity" EXACT [EC:2.3.3.6]
xref: EC:2.3.3.6
xref: MetaCyc:2-ETHYLMALATE-SYNTHASE-RXN
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050439
name: 2-hydroxy-3-oxoadipate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 ." [EC:2.2.1.5, MetaCyc:2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN]
synonym: "2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity" EXACT [EC:2.2.1.5]
synonym: "2-hydroxy-3-oxoadipate synthetase activity" EXACT [EC:2.2.1.5]
synonym: "2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.5]
synonym: "alpha-ketoglutaric-glyoxylic carboligase activity" EXACT [EC:2.2.1.5]
synonym: "oxoglutarate: glyoxylate carboligase activity" EXACT [EC:2.2.1.5]
synonym: "oxoglutarate:glyoxylate carboligase activity" EXACT [EC:2.2.1.5]
xref: EC:2.2.1.5
xref: MetaCyc:2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0050440
name: 2-methylcitrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: propanoyl-CoA + H2O + oxaloacetate = (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA." [EC:2.3.3.5, MetaCyc:2-METHYLCITRATE-SYNTHASE-RXN]
subset: gosubset_prok
synonym: "2-methylcitrate oxaloacetate-lyase activity" EXACT [EC:2.3.3.5]
synonym: "MCS activity" EXACT [EC:2.3.3.5]
synonym: "methylcitrate synthase activity" EXACT [EC:2.3.3.5]
synonym: "methylcitrate synthetase activity" EXACT [EC:2.3.3.5]
synonym: "propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming)" EXACT [EC:2.3.3.5]
xref: EC:2.3.3.5
xref: MetaCyc:2-METHYLCITRATE-SYNTHASE-RXN
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050441
name: 3-ethylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: butanoyl-CoA + H2O + glyoxylate = 3-ethylmalate + CoA ." [EC:2.3.3.7, MetaCyc:3-ETHYLMALATE-SYNTHASE-RXN]
synonym: "2-ethyl-3-hydroxybutanedioate synthase activity" EXACT [EC:2.3.3.7]
synonym: "3-ethylmalate glyoxylate-lyase (CoA-butanoylating) activity" EXACT [EC:2.3.3.7]
synonym: "butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming)" EXACT [EC:2.3.3.7]
xref: EC:2.3.3.7
xref: MetaCyc:3-ETHYLMALATE-SYNTHASE-RXN
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050442
name: 3-propylmalate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: pentanoyl-CoA + H2O + glyoxylate = 3-propylmalate + CoA ." [EC:2.3.3.12, MetaCyc:3-PROPYLMALATE-SYNTHASE-RXN]
synonym: "3-(n-propyl)-malate synthase activity" EXACT [EC:2.3.3.12]
synonym: "3-propylmalate glyoxylate-lyase (CoA-pentanoylating) activity" EXACT [EC:2.3.3.12]
synonym: "beta-n-propylmalate synthase activity" EXACT [EC:2.3.3.12]
synonym: "n-propylmalate synthase activity" EXACT [EC:2.3.3.12]
synonym: "N-propylmalate synthase activity" EXACT [EC:2.3.3.12]
synonym: "pentanoyl-CoA:glyoxylate C-pentanoyltransferase (thioester-hydrolysing, 1-carboxybutyl-forming)" EXACT [EC:2.3.3.12]
xref: EC:2.3.3.12
xref: MetaCyc:3-PROPYLMALATE-SYNTHASE-RXN
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050444
name: aquacobalamin reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 cob(II)alamin + NADP+ = 2 aquacob(III)alamin + NADPH + H+." [EC:1.16.1.5, MetaCyc:AQUACOBALAMIN-REDUCTASE-NADPH-RXN]
synonym: "aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) activity" EXACT [EC:1.16.1.5]
synonym: "aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.16.1.5]
synonym: "cob(II)alamin:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.5]
synonym: "NADPH-linked aquacobalamin reductase activity" EXACT [EC:1.16.1.5]
synonym: "NADPH2:aquacob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.5]
synonym: "NADPH:aquacob(III)alamin oxidoreductase activity" EXACT [EC:1.16.1.5]
xref: EC:1.16.1.5
xref: MetaCyc:AQUACOBALAMIN-REDUCTASE-NADPH-RXN
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0050445
name: asparagusate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD+ = asparagusate + NADH + H+." [EC:1.8.1.11, MetaCyc:ASPARAGUSATE-REDUCTASE-NADH-RXN]
synonym: "3-mercapto-2-mercaptomethylpropanoate:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.11]
synonym: "asparagusate dehydrogenase activity" EXACT [EC:1.8.1.11]
synonym: "asparagusate reductase (NADH) activity" EXACT []
synonym: "asparagusate reductase (NADH2)" EXACT [EC:1.8.1.11]
synonym: "asparagusic dehydrogenase activity" EXACT [EC:1.8.1.11]
synonym: "NADH2:asparagusate oxidoreductase activity" EXACT [EC:1.8.1.11]
synonym: "NADH:asparagusate oxidoreductase activity" EXACT [EC:1.8.1.11]
xref: EC:1.8.1.11
xref: MetaCyc:ASPARAGUSATE-REDUCTASE-NADH-RXN
is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050446
name: azobenzene reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+." [EC:1.7.1.6, MetaCyc:AZOBENZENE-REDUCTASE-RXN]
synonym: "azo reductase activity" BROAD [EC:1.7.1.6]
synonym: "azo-dye reductase activity" BROAD [EC:1.7.1.6]
synonym: "azoreductase activity" BROAD [EC:1.7.1.6]
synonym: "dibromopropylaminophenylazobenzoic azoreductase activity" EXACT [EC:1.7.1.6]
synonym: "dimethylaminobenzene reductase activity" EXACT [EC:1.7.1.6]
synonym: "methyl red azoreductase activity" NARROW [EC:1.7.1.6]
synonym: "N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.6]
synonym: "N,N-dimethyl-4-phenylazoaniline azoreductase activity" EXACT [EC:1.7.1.6]
synonym: "NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase activity" EXACT [EC:1.7.1.6]
synonym: "NADPH-dependent azoreductase activity" BROAD [EC:1.7.1.6]
synonym: "NADPH2-dependent azoreductase activity" EXACT [EC:1.7.1.6]
synonym: "NADPH2:4-(dimethylamino)azobenzene oxidoreductase activity" EXACT [EC:1.7.1.6]
synonym: "NADPH:4-(dimethylamino)azobenzene oxidoreductase activity" EXACT [EC:1.7.1.6]
synonym: "NC-reductase activity" NARROW [EC:1.7.1.6]
synonym: "new coccine (NC)-reductase" RELATED [EC:1.7.1.6]
synonym: "New coccine (NC)-reductase activity" NARROW [EC:1.7.1.6]
synonym: "nicotinamide adenine dinucleotide (phosphate) azoreductase activity" EXACT [EC:1.7.1.6]
synonym: "orange I azoreductase activity" NARROW [EC:1.7.1.6]
synonym: "orange II azoreductase activity" NARROW [EC:1.7.1.6]
synonym: "p-aminoazobenzene reductase activity" EXACT [EC:1.7.1.6]
synonym: "p-dimethylaminoazobenzene azoreductase activity" EXACT [EC:1.7.1.6]
xref: EC:1.7.1.6
xref: MetaCyc:AZOBENZENE-REDUCTASE-RXN
xref: UM-BBD_enzymeID:e0514
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0050447
name: zeatin 9-aminocarboxyethyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-acetyl-L-serine + zeatin = lupinate + acetate." [EC:2.5.1.50, MetaCyc:BETA-9-CYTOKININ-ALANINE-SYNTHASE-RXN]
synonym: "3-O-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.50]
synonym: "beta-(9-cytokinin)-alanine synthase activity" EXACT []
synonym: "beta-(9-cytokinin)alanine synthase activity" EXACT [EC:2.5.1.50]
synonym: "lupinate synthetase activity" EXACT [EC:2.5.1.50]
synonym: "lupinic acid synthase activity" EXACT [EC:2.5.1.50]
synonym: "lupinic acid synthetase activity" EXACT [EC:2.5.1.50]
synonym: "O-acetyl-L-serine acetate-lyase (adding N(6)-substituted adenine) activity" EXACT [EC:2.5.1.50]
synonym: "O-acetyl-L-serine acetate-lyase (adding N6-substituted adenine)" EXACT [EC:2.5.1.50]
synonym: "O3-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.50]
xref: EC:2.5.1.50
xref: MetaCyc:BETA-9-CYTOKININ-ALANINE-SYNTHASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050448
name: beta-cyclopiazonate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-cyclopiazonate + acceptor = alpha-cyclopiazonate + reduced acceptor." [EC:1.21.99.1, MetaCyc:BETA-CYCLOPIAZONATE-DEHYDROGENASE-RXN]
synonym: "b-cyclopiazonate dehydrogenase activity" EXACT []
synonym: "beta-cyclopiazonate oxidocyclase activity" EXACT [EC:1.21.99.1]
synonym: "beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing)" EXACT [EC:1.21.99.1]
synonym: "beta-cyclopiazonate:acceptor oxidoreductase (cyclizing)" EXACT [EC:1.21.99.1]
synonym: "beta-cyclopiazonic oxidocyclase activity" EXACT [EC:1.21.99.1]
xref: EC:1.21.99.1
xref: MetaCyc:BETA-CYCLOPIAZONATE-DEHYDROGENASE-RXN
is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond

[Term]
id: GO:0050449
name: casbene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate = casbene + diphosphate." [EC:4.2.3.8, MetaCyc:CASBENE-SYNTHASE-RXN]
synonym: "casbene synthetase activity" EXACT [EC:4.2.3.8]
synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.8]
synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming)" EXACT [EC:4.2.3.8]
xref: EC:4.2.3.8
xref: MetaCyc:CASBENE-SYNTHASE-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050450
name: citrate (Re)-synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the re-face of oxaloacetate; acetyl-CoA provides the two carbon atoms of the pro-R carboxymethyl group." [EC:2.3.3.3, ISBN:0121227073, MetaCyc:CITRATE-RE-SYNTHASE-RXN]
synonym: "(R)-citrate synthase activity" EXACT [EC:2.3.3.3]
synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]" RELATED [EC:2.3.3.3]
synonym: "citrate oxaloacetate-lyase ((pro-3R)-CH(2)COO(-)->acetyl-CoA) activity" EXACT [EC:2.3.3.3]
synonym: "citrate oxaloacetate-lyase [(pro-3R)-CH2COO-rightacetyl-CoA]" RELATED [EC:2.3.3.3]
synonym: "Re-citrate-synthase activity" EXACT [EC:2.3.3.3]
xref: EC:2.3.3.3
xref: MetaCyc:CITRATE-RE-SYNTHASE-RXN
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050451
name: CoA-disulfide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 CoA + NAD+ = CoA-disulfide + NADH + H+." [EC:1.8.1.14, MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN]
synonym: "CoA-disulfide reductase (NAD(P)H) activity" RELATED [EC:1.8.1.14]
synonym: "CoA-disulfide reductase (NADH) activity" EXACT []
synonym: "CoA-disulfide reductase (NADH2)" EXACT [EC:1.8.1.14]
synonym: "CoA-disulfide reductase [NAD(P)H]" RELATED [EC:1.8.1.14]
synonym: "CoA-disulphide reductase activity" EXACT []
synonym: "CoA:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.14]
synonym: "CoA:NAD+ oxidoreductase activity" EXACT [EC:1.8.1.14]
synonym: "CoADR activity" EXACT [EC:1.8.1.14]
synonym: "coenzyme A disulfide reductase activity" EXACT [EC:1.8.1.14]
synonym: "NADH2:CoA-disulfide oxidoreductase activity" EXACT [EC:1.8.1.14]
synonym: "NADH:CoA-disulfide oxidoreductase activity" EXACT [EC:1.8.1.14]
xref: EC:1.8.1.14
xref: MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN
is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050452
name: CoA-glutathione reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+." [EC:1.8.1.10, MetaCyc:COA-GLUTATHIONE-REDUCTASE-NADPH-RXN]
synonym: "CoA-glutathione reductase (NADPH) activity" EXACT []
synonym: "coenzyme A disulfide-glutathione reductase activity" EXACT [EC:1.8.1.10]
synonym: "coenzyme A glutathione disulfide reductase activity" EXACT [EC:1.8.1.10]
synonym: "glutathione:NADP+ oxidoreductase (CoA-acylating)" EXACT [EC:1.8.1.10]
synonym: "NADPH-dependent coenzyme A-SS-glutathione reductase activity" EXACT [EC:1.8.1.10]
synonym: "NADPH2:CoA-glutathione oxidoreductase activity" EXACT [EC:1.8.1.10]
synonym: "NADPH:CoA-glutathione oxidoreductase activity" EXACT [EC:1.8.1.10]
xref: EC:1.8.1.10
xref: MetaCyc:COA-GLUTATHIONE-REDUCTASE-NADPH-RXN
is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050453
name: cob(II)alamin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 cob(I)alamin + NAD+ = 2 cob(II)alamin + NADH + H+." [EC:1.16.1.4, MetaCyc:COBIIALAMIN-REDUCTASE-RXN]
synonym: "B(12r) reductase activity" EXACT [EC:1.16.1.4]
synonym: "B12r reductase activity" EXACT [EC:1.16.1.4]
synonym: "cob(I)alamin:NAD+ oxidoreductase activity" EXACT [EC:1.16.1.4]
synonym: "NADH2:cob(II)alamin oxidoreductase activity" EXACT [EC:1.16.1.4]
synonym: "NADH:cob(II)alamin oxidoreductase activity" EXACT [EC:1.16.1.4]
synonym: "vitamin B(12r) reductase activity" EXACT [EC:1.16.1.4]
synonym: "vitamin B12 reductase activity" EXACT []
synonym: "vitamin B12 reduction" RELATED []
synonym: "vitamin B12r reductase activity" EXACT [EC:1.16.1.4]
xref: EC:1.16.1.4
xref: MetaCyc:COBIIALAMIN-REDUCTASE-RXN
is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor

[Term]
id: GO:0050454
name: coenzyme F420 hydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2 + coenzyme F420 = reduced coenzyme F420." [EC:1.12.98.1, MetaCyc:COENZYME-F420-HYDROGENASE-RXN]
subset: gosubset_prok
synonym: "8-hydroxy-5-deazaflavin-reducing hydrogenase activity" EXACT [EC:1.12.98.1]
synonym: "coenzyme F420-dependent hydrogenase activity" EXACT [EC:1.12.98.1]
synonym: "F420-reducing hydrogenase activity" EXACT [EC:1.12.98.1]
synonym: "hydrogen:coenzyme F420 oxidoreductase activity" EXACT [EC:1.12.98.1]
xref: EC:1.12.98.1
xref: MetaCyc:COENZYME-F420-HYDROGENASE-RXN
is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors

[Term]
id: GO:0050455
name: columbamine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 columbamine + O2 = 2 berberine + 2 H2O." [EC:1.21.3.2, MetaCyc:COLUMBAMINE-OXIDASE-RXN]
synonym: "berberine synthase activity" EXACT [EC:1.21.3.2]
synonym: "columbamine:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.21.3.2]
xref: EC:1.21.3.2
xref: MetaCyc:COLUMBAMINE-OXIDASE-RXN
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0050456
name: cystine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 L-cysteine + NAD+ = L-cystine + NADH + H+." [EC:1.8.1.6, MetaCyc:CYSTINE-REDUCTASE-NADH-RXN]
subset: gosubset_prok
synonym: "cystine reductase (NADH) activity" EXACT [EC:1.8.1.6]
synonym: "cystine reductase (NADH2)" EXACT [EC:1.8.1.6]
synonym: "L-cysteine:NAD+ oxidoreductase" EXACT [EC:1.8.1.6]
synonym: "NADH-dependent cystine reductase activity" EXACT [EC:1.8.1.6]
synonym: "NADH2:L-cystine oxidoreductase" EXACT [EC:1.8.1.6]
synonym: "NADH:L-cystine oxidoreductase activity" EXACT [EC:1.8.1.6]
xref: EC:1.8.1.6
xref: MetaCyc:CYSTINE-REDUCTASE-NADH-RXN
is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050457
name: decylcitrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: lauroyl-CoA + H2O + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA ." [EC:2.3.3.2, MetaCyc:DECYLCITRATE-SYNTHASE-RXN]
synonym: "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA- acylating) activity" EXACT [EC:2.3.3.2]
synonym: "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA-acylating)" EXACT [EC:2.3.3.2]
synonym: "2-decylcitrate synthase activity" EXACT [EC:2.3.3.2]
synonym: "dodecanoyl-CoA:oxaloacetate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)" EXACT [EC:2.3.3.2]
xref: EC:2.3.3.2
xref: MetaCyc:DECYLCITRATE-SYNTHASE-RXN
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050458
name: decylhomocitrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: dodecanoyl-CoA + H2O + 2-oxoglutarate = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA ." [EC:2.3.3.4, MetaCyc:DECYLHOMOCITRATE-SYNTHASE-RXN]
synonym: "2-decylhomocitrate synthase activity" EXACT [EC:2.3.3.4]
synonym: "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acylating) activity" EXACT [EC:2.3.3.4]
synonym: "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acylating)" EXACT [EC:2.3.3.4]
synonym: "dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)" EXACT [EC:2.3.3.4]
xref: EC:2.3.3.4
xref: MetaCyc:DECYLHOMOCITRATE-SYNTHASE-RXN
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050459
name: ethanolamine-phosphate phospho-lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethanolamine phosphate + H2O = acetaldehyde + NH3 + phosphate." [EC:4.2.3.2, MetaCyc:ETHANOLAMINE-PHOSPHATE-PHOSPHO-LYASE-RXN]
synonym: "amino alcohol O-phosphate phospholyase activity" BROAD [EC:4.2.3.2]
synonym: "ethanolamine-phosphate phospho-lyase (deaminating)" EXACT [EC:4.2.3.2]
synonym: "ethanolamine-phosphate phospho-lyase (deaminating; acetaldehyde-forming)" EXACT [EC:4.2.3.2]
synonym: "O-phosphoethanolamine-phospholyase activity" EXACT [EC:4.2.3.2]
synonym: "O-phosphorylethanol-amine phospho-lyase activity" EXACT [EC:4.2.3.2]
xref: EC:4.2.3.2
xref: MetaCyc:ETHANOLAMINE-PHOSPHATE-PHOSPHO-LYASE-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050460
name: hydroxylamine reductase (NADH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+." [EC:1.7.1.10, MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN]
synonym: "ammonium dehydrogenase activity" EXACT [EC:1.7.1.10]
synonym: "ammonium:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.10]
synonym: "hydroxylamine reductase (NADH2)" EXACT [EC:1.7.1.10]
synonym: "N-hydroxy amine reductase activity" EXACT [EC:1.7.1.10]
synonym: "NADH-hydroxylamine reductase activity" EXACT [EC:1.7.1.10]
synonym: "NADH2:hydroxylamine oxidoreductase activity" EXACT [EC:1.7.1.10]
synonym: "NADH:hydroxylamine oxidoreductase activity" EXACT [EC:1.7.1.10]
xref: EC:1.7.1.10
xref: MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0050461
name: L-mimosine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O3-acetyl-L-serine + 3,4-dihydroxypyridine = 3-(3,4-dihydroxypyridin-1-yl)-L-alanine + acetate." [EC:2.5.1.52, MetaCyc:L-MIMOSINE-SYNTHASE-RXN]
synonym: "3-O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.52]
synonym: "O(3)-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl) activity" EXACT [EC:2.5.1.52]
synonym: "O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl)" EXACT [EC:2.5.1.52]
synonym: "O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.52]
xref: EC:2.5.1.52
xref: MetaCyc:L-MIMOSINE-SYNTHASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050462
name: N-acetylneuraminate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate ." [EC:2.5.1.56, MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN]
synonym: "(NANA)condensing enzyme activity" EXACT [EC:2.5.1.56]
synonym: "N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.56]
synonym: "N-acetylneuraminic acid synthase activity" EXACT [EC:2.5.1.56]
synonym: "NeuAc synthase activity" EXACT [EC:2.5.1.56]
synonym: "phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.56]
xref: EC:2.5.1.56
xref: MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050463
name: nitrate reductase [NAD(P)H] activity
namespace: molecular_function
def: "Catalysis of the reaction: NO2- (nitrite) + NAD(P)+ + H2O = NO3- (nitrate) + NAD(P)H + H+." [EC:1.7.1.2, MetaCyc:NITRATE-REDUCTASE-NADPH-RXN]
synonym: "assimilatory NAD(P)H-nitrate reductase activity" RELATED [EC:1.7.1.2]
synonym: "assimilatory nitrate reductase activity" RELATED [EC:1.7.1.2]
synonym: "NAD(P)H bispecific nitrate reductase activity" EXACT [EC:1.7.1.2]
synonym: "NAD(P)H-nitrate reductase activity" EXACT [EC:1.7.1.2]
synonym: "NAD(P)H2:nitrate oxidoreductase activity" EXACT [EC:1.7.1.2]
synonym: "NAD(P)H:nitrate oxidoreductase activity" EXACT [EC:1.7.1.2]
synonym: "nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.7.1.2]
synonym: "nitrate reductase [NAD(P)H2]" RELATED [EC:1.7.1.2]
synonym: "nitrate reductase NAD(P)H activity" EXACT [EC:1.7.1.2]
synonym: "nitrite:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.2]
xref: EC:1.7.1.2
xref: MetaCyc:NITRATE-REDUCTASE-NADPH-RXN
is_a: GO:0008940 ! nitrate reductase activity
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0050464
name: nitrate reductase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: NO2- (nitrite) + NADP+ + H2O = NO3- (nitrate) + NADPH + H+." [EC:1.7.1.3, MetaCyc:NITRATE-REDUCTASE-NADPH-RXN]
synonym: "assimilatory NADPH-nitrate reductase activity" EXACT [EC:1.7.1.3]
synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.3]
synonym: "assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity" EXACT [EC:1.7.1.3]
synonym: "NADPH-nitrate reductase activity" EXACT [EC:1.7.1.3]
synonym: "NADPH:nitrate oxidoreductase activity" EXACT [EC:1.7.1.3]
synonym: "NADPH:nitrate reductase activity" EXACT [EC:1.7.1.3]
synonym: "nitrate reductase (NADPH(2)) activity" EXACT [EC:1.7.1.3]
synonym: "nitrate reductase (NADPH2)" EXACT [EC:1.7.1.3]
synonym: "nitrite:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.3]
synonym: "triphosphopyridine nucleotide-nitrate reductase activity" EXACT [EC:1.7.1.3]
xref: EC:1.7.1.3
xref: MetaCyc:NITRATE-REDUCTASE-NADPH-RXN
is_a: GO:0008940 ! nitrate reductase activity
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0050465
name: nitroquinoline-N-oxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+." [EC:1.7.1.9, MetaCyc:1.7.1.9-RXN]
synonym: "4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase activity" EXACT [EC:1.7.1.9]
synonym: "4-nitroquinoline 1-oxide reductase activity" EXACT [EC:1.7.1.9]
synonym: "4NQO reductase activity" EXACT [EC:1.7.1.9]
synonym: "NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase activity" EXACT [EC:1.7.1.9]
synonym: "NAD(P)H:4-nitroquinoline-N-oxide oxidoreductase activity" EXACT [EC:1.7.1.9]
xref: EC:1.7.1.9
xref: MetaCyc:1.7.1.9-RXN
is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

[Term]
id: GO:0050466
name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is not disulfide or oxygen." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0046992

[Term]
id: GO:0050467
name: pentalenene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = pentalenene + diphosphate." [EC:4.2.3.7, MetaCyc:PENTALENENE-SYNTHASE-RXN]
subset: gosubset_prok
synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming)" EXACT [EC:4.2.3.7]
synonym: "2-trans,6-trans-farnesyldiphosphate diphosphate-lyase (cyclizing, pentalenene-forming)" EXACT [EC:4.2.3.7]
synonym: "pentalenene synthetase activity" EXACT [EC:4.2.3.7]
xref: EC:4.2.3.7
xref: MetaCyc:PENTALENENE-SYNTHASE-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050468
name: reticuline oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-reticuline + O2 = (S)-scoulerine + H2O2." [EC:1.21.3.3, MetaCyc:RETICULINE-OXIDASE-RXN]
synonym: "(S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming)" EXACT [EC:1.21.3.3]
synonym: "BBE" RELATED [EC:1.21.3.3]
synonym: "berberine bridge enzyme activity" EXACT [EC:1.21.3.3]
synonym: "berberine-bridge-forming enzyme activity" EXACT [EC:1.21.3.3]
synonym: "tetrahydroprotoberberine synthase activity" EXACT [EC:1.21.3.3]
xref: EC:1.21.3.3
xref: MetaCyc:RETICULINE-OXIDASE-RXN
is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor

[Term]
id: GO:0050469
name: sabinene-hydrate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + geranyl-PP = pyrophosphate + sabinene hydrate." [EC:4.2.3.11, MetaCyc:4.2.3.11-RXN]
synonym: "geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)" EXACT [EC:4.2.3.11]
synonym: "sabinene hydrate cyclase activity" EXACT [EC:4.2.3.11]
xref: EC:4.2.3.11
xref: MetaCyc:4.2.3.11-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050470
name: trimethylamine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein." [EC:1.5.8.2, MetaCyc:1.5.8.2-RXN]
subset: gosubset_prok
synonym: "TMADh activity" EXACT [EC:1.5.8.2]
synonym: "trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating)" EXACT [EC:1.5.8.2]
xref: EC:1.5.8.2
xref: MetaCyc:1.5.8.2-RXN
xref: UM-BBD_enzymeID:e0854
is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, with a flavin as acceptor

[Term]
id: GO:0050471
name: uracilylalanine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate." [EC:2.5.1.53, MetaCyc:URACILYLALANINE-SYNTHASE-RXN]
synonym: "3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.53]
synonym: "isowillardiine synthase activity" EXACT [EC:2.5.1.53]
synonym: "O(3)-acetyl-L-serine acetate-lyase (adding uracil) activity" EXACT [EC:2.5.1.53]
synonym: "O3-acetyl-L-serine acetate-lyase (adding uracil)" EXACT [EC:2.5.1.53]
synonym: "O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity" EXACT [EC:2.5.1.53]
synonym: "willardiine synthase activity" EXACT [EC:2.5.1.53]
synonym: "Willardiine synthase activity" EXACT [EC:2.5.1.53]
xref: EC:2.5.1.53
xref: MetaCyc:URACILYLALANINE-SYNTHASE-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050472
name: zeatin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrozeatin + NADP+ = zeatin + NADPH." [EC:1.3.1.69, MetaCyc:ZEATIN-REDUCTASE-RXN]
synonym: "dihydrozeatin:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.69]
xref: EC:1.3.1.69
xref: MetaCyc:ZEATIN-REDUCTASE-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050473
name: arachidonate 15-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate." [EC:1.13.11.33]
subset: gosubset_prok
synonym: "15-lipoxygenase activity" EXACT [EC:1.13.11.33]
synonym: "arachidonate omega(6) lipoxygenase activity" EXACT [EC:1.13.11.33]
synonym: "arachidonate omega6 lipoxygenase activity" EXACT [EC:1.13.11.33]
synonym: "arachidonate:oxygen 15-oxidoreductase activity" EXACT [EC:1.13.11.33]
synonym: "linoleic acid omega6-lipoxygenase activity" EXACT [EC:1.13.11.33]
synonym: "omega6 lipoxygenase activity" EXACT [EC:1.13.11.33]
xref: EC:1.13.11.33
xref: MetaCyc:ARACHIDONATE-15-LIPOXYGENASE-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050474
name: (S)-norcoclaurine synthase activity
namespace: molecular_function
alt_id: GO:0050475
def: "Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O." [EC:4.2.1.78]
synonym: "(S)-norlaudanosoline synthase activity" EXACT [EC:4.2.1.78]
synonym: "4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine)" EXACT [EC:4.2.1.78]
synonym: "4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine; (S)-norcoclaurine-forming]" RELATED [EC:4.2.1.78]
xref: EC:4.2.1.78
xref: MetaCyc:S-NORLAUDANOSOLINE-SYNTHASE-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050476
name: acetylenedicarboxylate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate." [EC:4.1.1.78]
synonym: "acetylenedicarboxylate carboxy-lyase (pyruvate-forming)" EXACT [EC:4.1.1.78]
synonym: "acetylenedicarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.78]
synonym: "acetylenedicarboxylate hydrase activity" EXACT [EC:4.1.1.78]
synonym: "acetylenedicarboxylate hydratase activity" EXACT [EC:4.1.1.78]
xref: EC:4.1.1.78
xref: MetaCyc:4.1.1.78-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050477
name: acyl-lysine deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate." [EC:3.5.1.17]
synonym: "6-N-acyl-L-lysine amidohydrolase activity" EXACT [EC:3.5.1.17]
synonym: "epsilon-lysine acylase activity" EXACT [EC:3.5.1.17]
synonym: "N6-acyl-L-lysine amidohydrolase activity" EXACT [EC:3.5.1.17]
xref: EC:3.5.1.17
xref: MetaCyc:ACYL-LYSINE-DEACYLASE-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050478
name: anthranilate 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + anthranilate + (tetrahydrobiopterin/tetrahydropteridine) = 3-hydroxanthranilate + H2O + (dihydrobiopterin/dihydropteridine)." [EC:1.14.16.3, MetaCyc:ANTHRANILATE-3-MONOOXYGENASE-RXN]
synonym: "anthranilate 3-hydroxylase activity" EXACT []
synonym: "anthranilate,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.16.3]
synonym: "anthranilic acid hydroxylase activity" BROAD [EC:1.14.16.3]
synonym: "anthranilic hydroxylase activity" BROAD [EC:1.14.16.3]
xref: EC:1.14.16.3
xref: MetaCyc:1.14.16.3-RXN
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050479
name: glyceryl-ether monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine)." [EC:1.14.16.5, MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN]
synonym: "1-alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase activity" EXACT [EC:1.14.16.5]
synonym: "alkylglycerol monooxygenase activity" EXACT [EC:1.14.16.5]
synonym: "glyceryl ether oxygenase activity" EXACT [EC:1.14.16.5]
synonym: "glyceryl etherase activity" EXACT [EC:1.14.16.5]
synonym: "glyceryl-ether cleaving enzyme activity" EXACT [EC:1.14.16.5]
synonym: "O-alkylglycerol monooxygenase activity" EXACT [EC:1.14.16.5]
xref: EC:1.14.16.5
xref: MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050480
name: imidazolonepropionase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = H+ + N-formimidoyl-L-glutamate." [EC:3.5.2.7, MetaCyc:IMIDAZOLONEPROPIONASE-RXN]
subset: gosubset_prok
synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase activity" EXACT [EC:3.5.2.7]
synonym: "4(5)-imidazolone-5(4)-propionic acid hydrolase activity" EXACT [EC:3.5.2.7]
synonym: "imidazolone propionic acid hydrolase activity" EXACT [EC:3.5.2.7]
synonym: "imidazolone-5-propionate hydrolase activity" EXACT [EC:3.5.2.7]
xref: EC:3.5.2.7
xref: MetaCyc:IMIDAZOLONEPROPIONASE-RXN
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0050481
name: mandelate 4-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + O2 + (tetrahydrobiopterin/tetrahydropteridine) = (S)-4-hydroxymandelate + H2O + (dihydrobiopterin/dihydropteridine). (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate." [EC:1.14.16.6, MetaCyc:MANDELATE-4-MONOOXYGENASE-RXN]
synonym: "(S)-2-hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.16.6]
synonym: "L-mandelate 4-hydroxylase activity" EXACT []
synonym: "mandelic acid 4-hydroxylase activity" EXACT [EC:1.14.16.6]
xref: EC:1.14.16.6
xref: MetaCyc:MANDELATE-4-MONOOXYGENASE-RXN
is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050482
name: arachidonic acid secretion
namespace: biological_process
def: "The controlled release of arachidonic acid from a cell or group of cells." [GOC:ai]
is_a: GO:0015909 ! long-chain fatty acid transport
is_a: GO:0032309 ! icosanoid secretion
is_a: GO:0046717 ! acid secretion

[Term]
id: GO:0050483
name: IMP 5'-nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate." [GOC:ai]
synonym: "IMP 5' nucleotidase activity" EXACT []
synonym: "IMP-GMP specific 5'-nucleotidase activity" NARROW []
xref: MetaCyc:RXN-7607
is_a: GO:0008253 ! 5'-nucleotidase activity

[Term]
id: GO:0050484
name: GMP 5'-nucleotidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate." [GOC:ai]
synonym: "GMP 5' nucleotidase activity" EXACT []
synonym: "IMP-GMP specific 5'-nucleotidase activity" NARROW []
xref: MetaCyc:RXN-7609
is_a: GO:0008253 ! 5'-nucleotidase activity

[Term]
id: GO:0050485
name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide." [GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulphide as acceptor" EXACT []
xref: EC:1.21.4
is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond

[Term]
id: GO:0050486
name: intramolecular transferase activity, transferring hydroxy groups
namespace: molecular_function
def: "Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule." [GOC:mah]
subset: gosubset_prok
xref: EC:5.4.4
is_a: GO:0016866 ! intramolecular transferase activity

[Term]
id: GO:0050487
name: sulfoacetaldehyde acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: SO3(2-) (sulfite) + acetyl phosphate = 2-sulfoacetaldehyde + phosphate." [EC:2.3.3.15]
comment: Note that the enzyme sulfoacetaldehyde acetyltransferase also has sulfoacetaldehyde lyase activity (GO:0050312).
subset: gosubset_prok
synonym: "acetyl-phosphate:sulfite S-acetyltransferase (acyl-phosphate hydrolysing, 2-oxoethyl-forming)" EXACT [EC:2.3.3.15]
synonym: "sulphoacetaldehyde acetyltransferase activity" EXACT []
xref: EC:2.3.3.15
is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

[Term]
id: GO:0050488
name: ecdysteroid UDP-glucosyltransferase activity
namespace: molecular_function
alt_id: GO:0050489
def: "Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid." [GOC:ai, PMID:10073711]
synonym: "ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity" RELATED []
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050490
name: 1,4-lactonase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid." [EC:3.1.1.25, MetaCyc:14-LACTONASE-RXN]
synonym: "1,4-lactone hydroxyacylhydrolase activity" EXACT [EC:3.1.1.25]
synonym: "gamma-lactonase activity" EXACT [EC:3.1.1.25]
xref: EC:3.1.1.25
xref: MetaCyc:14-LACTONASE-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050491
name: sulcatone reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD+ + sulcatol = NADH + H+ + sulcatone." [EC:1.1.1.260, MetaCyc:1.1.1.260-RXN]
synonym: "sulcatol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.260]
xref: EC:1.1.1.260
xref: MetaCyc:1.1.1.260-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050492
name: glycerol-1-phosphate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate." [EC:1.1.1.261, MetaCyc:1.1.1.261-RXN]
subset: gosubset_prok
synonym: "sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.261]
xref: EC:1.1.1.261
xref: MetaCyc:1.1.1.261-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050493
name: GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-threonyl ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a threonyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0164]
subset: gosubset_prok
synonym: "GPI anchor anabolism via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor formation via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT []
synonym: "GPI anchor synthesis via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT []
xref: RESID:AA0164
is_a: GO:0006506 ! GPI anchor biosynthetic process
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0050494
name: GSI anchor biosynthetic process via N-glycyl-glycosylsphingolipidinositolethanolamine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0165]
subset: gosubset_prok
synonym: "GSI anchor anabolism via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT []
synonym: "GSI anchor formation via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT []
synonym: "GSI anchor synthesis via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT []
xref: RESID:AA0165
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0042082 ! GSI anchor biosynthetic process

[Term]
id: GO:0050495
name: peptidyl-glycyl-phosphatidylethanolamine biosynthetic process from peptidyl-glycine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked phosphatide following hydrolysis of a glycyl-peptide bond, as in the cleavage of arginine from the carboxy-terminal of Apg8 followed by its amidation with phosphatidylethanolamine." [RESID:AA0346]
subset: gosubset_prok
synonym: "peptidyl-glycyl-phosphatidylethanolamine anabolism from peptidyl-glycine" EXACT []
synonym: "peptidyl-glycyl-phosphatidylethanolamine formation from peptidyl-glycine" EXACT []
synonym: "peptidyl-glycyl-phosphatidylethanolamine synthesis from peptidyl-glycine" EXACT []
xref: RESID:AA0346
is_a: GO:0018201 ! peptidyl-glycine modification

[Term]
id: GO:0050496
name: peptidyl-L-glutamyl 5-omega-hydroxyceramide ester biosynthetic process from peptidyl-glutamine
namespace: biological_process
def: "The posttranslational modification of peptidyl-glutamine residues by deamidation and esterification with omega-hydroxyceramide." [PMID:10411887, RESID:AA0347]
subset: gosubset_prok
synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester anabolism from peptidyl-glutamine" EXACT []
synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester formation from peptidyl-glutamine" EXACT []
synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester synthesis from peptidyl-glutamine" EXACT []
xref: RESID:AA0340
is_a: GO:0018199 ! peptidyl-glutamine modification

[Term]
id: GO:0050497
name: transferase activity, transferring alkylthio groups
namespace: molecular_function
def: "Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor)." [GOC:ai]
subset: gosubset_prok
xref: EC:2.8.4
is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups

[Term]
id: GO:0050498
name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated." [GOC:mah]
subset: gosubset_prok
xref: EC:1.14.20
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050499
name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H." [GOC:mah]
subset: gosubset_prok
xref: EC:1.20.1
is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors

[Term]
id: GO:0050500
name: 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1,3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate." [EC:2.4.1.211, MetaCyc:2.4.1.211-RXN]
synonym: "1,3-b-galactosyl-N-acetylhexosamine phosphorylase activity" EXACT []
synonym: "beta-D-galactopyranosyl-(1->3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity" EXACT [EC:2.4.1.211]
xref: EC:2.4.1.211
xref: MetaCyc:2.4.1.211-RXN
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0050501
name: hyaluronan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl(1,4)beta-D-glucuronosyl(1,3)](n) + 2n UDP." [EC:2.4.1.212, MetaCyc:2.4.1.212-RXN]
subset: gosubset_prok
synonym: "alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity" EXACT [EC:2.4.1.212]
synonym: "HAS activity" EXACT [EC:2.4.1.212]
synonym: "seHAS" RELATED [EC:2.4.1.212]
synonym: "spHAS" RELATED [EC:2.4.1.212]
xref: EC:2.4.1.212
xref: MetaCyc:2.4.1.212-RXN
is_a: GO:0008194 ! UDP-glycosyltransferase activity
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0050502
name: cis-zeatin O-beta-D-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + UDP." [EC:2.4.1.215, MetaCyc:2.4.1.215-RXN]
synonym: "cis-zeatin O-b-D-glucosyltransferase activity" EXACT []
synonym: "UDP-glucose:cis-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.215]
synonym: "UDPglucose:cis-zeatin O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.215]
xref: EC:2.4.1.215
xref: MetaCyc:RXN-4735
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050503
name: trehalose 6-phosphate phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate." [EC:2.4.1.216, MetaCyc:2.4.1.216-RXN]
subset: gosubset_prok
synonym: "trehalose 6-phosphate:phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.216]
xref: EC:2.4.1.216
xref: MetaCyc:2.4.1.216-RXN
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0050504
name: mannosyl-3-phosphoglycerate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate." [EC:2.4.1.217, MetaCyc:2.4.1.217-RXN]
subset: gosubset_prok
synonym: "GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.217]
synonym: "MPG synthase activity" EXACT [EC:2.4.1.217]
xref: EC:2.4.1.217
xref: MetaCyc:2.4.1.217-RXN
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0050505
name: hydroquinone glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydroquinone + UDP-D-glucose = hydroquinone-O-beta-D-glucopyranoside + UDP." [EC:2.4.1.218, MetaCyc:2.4.1.218-RXN]
synonym: "arbutin synthase activity" EXACT [EC:2.4.1.218]
synonym: "hydroquinone:O-glucosyltransferase activity" EXACT [EC:2.4.1.218]
synonym: "UDP-glucose:hydroquinone-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.218]
synonym: "UDPglucose:hydroquinone-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.218]
xref: EC:2.4.1.218
xref: MetaCyc:2.4.1.218-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050506
name: vomilenine glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: vomilenine + UDP-D-glucose = raucaffricine + UDP." [EC:2.4.1.219, MetaCyc:2.4.1.219-RXN]
synonym: "UDP-glucose:vomilenine 21-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219]
synonym: "UDPG:vomilenine 21-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219]
synonym: "UDPG:vomilenine 21beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.219]
synonym: "vomilenine-glucosyltransferase activity" EXACT [EC:2.4.1.219]
xref: EC:2.4.1.219
xref: MetaCyc:2.4.1.219-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050507
name: indoxyl-UDPG glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: indoxyl + UDP-D-glucose = indican + UDP." [EC:2.4.1.220, MetaCyc:2.4.1.220-RXN]
synonym: "indoxyl-UDPG-glucosyltransferase activity" EXACT [EC:2.4.1.220]
synonym: "UDP-glucose:indoxyl 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.220]
xref: EC:2.4.1.220
xref: MetaCyc:2.4.1.220-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050508
name: glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP." [EC:2.4.1.224, MetaCyc:2.4.1.224-RXN]
synonym: "alpha-N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.224]
synonym: "glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-a-N-acetylglucosaminyltransferase activity" EXACT []
synonym: "glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.224]
synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.224]
xref: EC:2.4.1.224
xref: MetaCyc:2.4.1.224-RXN
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0050509
name: N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.225, MetaCyc:2.4.1.225-RXN]
synonym: "heparan glucuronyltransferase II activity" EXACT [EC:2.4.1.225]
synonym: "N-acetylglucosaminyl-proteoglycan 4-b-glucuronosyltransferase activity" EXACT []
synonym: "N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase activity" EXACT [EC:2.4.1.225]
synonym: "UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase activity" EXACT [EC:2.4.1.225]
xref: EC:2.4.1.225
xref: MetaCyc:2.4.1.225-RXN
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0050510
name: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.226, MetaCyc:2.4.1.226-RXN]
synonym: "alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase activity" EXACT [EC:2.4.1.226]
synonym: "chondroitin glucuronyltransferase II activity" EXACT [EC:2.4.1.226]
synonym: "N-acetylgalactosaminyl-proteoglycan 3-b-glucuronosyltransferase activity" EXACT []
xref: EC:2.4.1.226
xref: MetaCyc:2.4.1.226-RXN
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0050511
name: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP." [EC:2.4.1.227, MetaCyc:2.4.1.227-RXN]
subset: gosubset_prok
synonym: "MurG transferase activity" RELATED [EC:2.4.1.227]
synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminlytransferase activity" EXACT [EC:2.4.1.227]
synonym: "UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase activity" EXACT [EC:2.4.1.227]
synonym: "undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase activity" EXACT [EC:2.4.1.227]
synonym: "undecaprenyldiphospho-muramoylpentapeptide b-N-acetylglucosaminyltransferase activity" EXACT []
xref: EC:2.4.1.227
xref: MetaCyc:NACGLCTRANS-RXN
xref: MetaCyc:RXN-8976
xref: MetaCyc:RXN-9672
is_a: GO:0008375 ! acetylglucosaminyltransferase activity

[Term]
id: GO:0050512
name: lactosylceramide 4-alpha-galactosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.228, MetaCyc:2.4.1.228-RXN]
synonym: "Gal-beta-1-4Glc-beta-1-Cer alpha-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.228]
synonym: "galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase activity" EXACT [EC:2.4.1.228]
synonym: "globotriaosylceramide/CD77 synthase activity" NARROW [EC:2.4.1.228]
synonym: "histo-blood group P(k) UDP-galactose activity" NARROW [EC:2.4.1.228]
synonym: "histo-blood group Pk UDP-galactose" RELATED [EC:2.4.1.228]
synonym: "lactosylceramide 4-a-galactosyltransferase activity" EXACT []
synonym: "UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.228]
xref: EC:2.4.1.228
xref: MetaCyc:2.4.1.228-RXN
is_a: GO:0035250 ! UDP-galactosyltransferase activity

[Term]
id: GO:0050513
name: glycoprotein 2-beta-D-xylosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine + UDP-L-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-[beta-D-xylosyl-(1,2)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine + UDP." [EC:2.4.2.38, MetaCyc:2.4.2.38-RXN]
synonym: "beta-1,2-xylosyltransferase activity" EXACT [EC:2.4.2.38]
synonym: "beta1,2-xylosyltransferase activity" EXACT [EC:2.4.2.38]
synonym: "glycoprotein 2-b-D-xylosyltransferase activity" EXACT []
xref: EC:2.4.2.38
xref: MetaCyc:2.4.2.38-RXN
is_a: GO:0035252 ! UDP-xylosyltransferase activity

[Term]
id: GO:0050514
name: homospermidine synthase (spermidine-specific) activity
namespace: molecular_function
def: "Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine." [EC:2.5.1.45, MetaCyc:2.5.1.45-RXN]
synonym: "spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming)" EXACT [EC:2.5.1.45]
xref: EC:2.5.1.45
xref: MetaCyc:2.5.1.45-RXN
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups

[Term]
id: GO:0050515
name: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
namespace: molecular_function
alt_id: GO:0008698
def: "Catalysis of the reaction: ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol." [EC:2.7.1.148, MetaCyc:2.7.1.148-RXN]
subset: gosubset_prok
synonym: "4-diphosphocytidyl-2-C-methyl-D-erythritol kinase activity" EXACT [EC:2.7.1.148]
synonym: "4-diphosphocytidyl-2C-methyl-D-erythritol kinase activity" EXACT []
synonym: "ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase activity" EXACT [EC:2.7.1.148]
synonym: "CDP-ME kinase activity" EXACT [EC:2.7.1.148]
synonym: "CMK activity" RELATED [EC:2.7.1.148]
xref: EC:2.7.1.148
xref: MetaCyc:2.7.1.148-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0050516
name: inositol polyphosphate multikinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate, and ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [EC:2.7.1.151, MetaCyc:2.7.1.151-RXN]
comment: This term was made obsolete because this activity is currently defined as catalyzing two sequential reactions based on a gene product. However, "inositol polyphosphate multikinase activity" in some organisms can catalyze additional reactions. In addition, the reactions listed in the definition can be catalyzed independently by other gene products.
synonym: "ArgRIII" RELATED [EC:2.7.1.151]
synonym: "AtIpk2-alpha activity" NARROW [EC:2.7.1.151]
synonym: "AtIpk2-beta activity" NARROW [EC:2.7.1.151]
synonym: "AtIpk2alpha" RELATED [EC:2.7.1.151]
synonym: "AtIpk2beta" RELATED [EC:2.7.1.151]
synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.151]
synonym: "inositol polyphosphate 6-/3-/5-kinase activity" EXACT [EC:2.7.1.151]
synonym: "inositol-polyphosphate multikinase activity" EXACT []
synonym: "IP3/IP4 6-/3-kinase activity" EXACT [EC:2.7.1.151]
synonym: "IP3/IP4 dual-specificity 6-/3-kinase activity" EXACT [EC:2.7.1.151]
synonym: "IpK2 activity" RELATED [EC:2.7.1.151]
synonym: "IpmK" RELATED [EC:2.7.1.151]
xref: EC:2.7.1.151
xref: MetaCyc:2.7.1.151-RXN
is_obsolete: true

[Term]
id: GO:0050517
name: inositol hexakisphosphate kinase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate, and ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)." [EC:2.7.4.21, MetaCyc:2.7.4.21-RXN]
comment: Note that this was EC:2.7.1.152. This term was made obsolete because this activity is currently defined as catalyzing two reactions based on a gene product. The reactions listed in the definition can be catalyzed independently by other gene products.
synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT [EC:2.7.4.21]
synonym: "ATP:1D-myo-inositol-hexakisphosphate phosphotransferase activity" EXACT [EC:2.7.4.21]
synonym: "inositol-hexakisphosphate kinase activity" EXACT []
xref: EC:2.7.4.21
xref: MetaCyc:2.7.1.152-RXN
is_obsolete: true

[Term]
id: GO:0050518
name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
namespace: molecular_function
alt_id: GO:0008699
def: "Catalysis of the reaction: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol." [EC:2.7.7.60, MetaCyc:2.7.7.60-RXN]
subset: gosubset_prok
synonym: "4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity" EXACT [EC:2.7.7.60]
synonym: "4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity" EXACT []
synonym: "CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity" EXACT []
synonym: "MCT activity" RELATED [EC:2.7.7.60]
synonym: "MEP cytidylyltransferase activity" EXACT []
xref: EC:2.7.7.60
xref: MetaCyc:2.7.7.60-RXN
is_a: GO:0070567 ! cytidylyltransferase activity

[Term]
id: GO:0050519
name: holo-citrate lyase synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = pyrophosphate + holo-citrate lyase." [EC:2.7.7.61, MetaCyc:2.7.7.61-RXN]
subset: gosubset_prok
synonym: "2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase activity" EXACT [EC:2.7.7.61]
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase activity" EXACT [EC:2.7.7.61]
synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase activity" EXACT [EC:2.7.7.61]
synonym: "CitX" RELATED [EC:2.7.7.61]
synonym: "holo-ACP synthase activity" RELATED [EC:2.7.7.61]
xref: EC:2.7.7.61
xref: MetaCyc:2.7.7.61-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0050520
name: phosphatidylcholine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: CDP-diacylglycerol + choline = CMP + phosphatidylcholine." [EC:2.7.8.24, MetaCyc:2.7.8.24-RXN]
subset: gosubset_prok
synonym: "CDP-diacylglycerol:choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24]
synonym: "CDP-diglyceride-choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24]
synonym: "CDPdiglyceride-choline O-phosphatidyltransferase activity" EXACT [EC:2.7.8.24]
synonym: "PC synthase activity" EXACT [EC:2.7.8.24]
xref: EC:2.7.8.24
xref: MetaCyc:2.7.8.24-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0050521
name: alpha-glucan, water dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate." [EC:2.7.9.4, MetaCyc:2.7.9.4-RXN]
synonym: "a-glucan, water dikinase activity" EXACT []
synonym: "alpha-glucan,water dikinase activity" EXACT [EC:2.7.9.4]
synonym: "ATP:alpha-glucan, water phosphotransferase activity" EXACT [EC:2.7.9.4]
synonym: "GWD" RELATED [EC:2.7.9.4]
synonym: "starch-related R1 protein activity" EXACT [EC:2.7.9.4]
xref: EC:2.7.9.4
xref: MetaCyc:2.7.9.4-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0050522
name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP." [GOC:ai]
subset: gosubset_prok
xref: EC:1.20.98
is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors

[Term]
id: GO:0050523
name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors
namespace: molecular_function
def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD or NADP." [GOC:ai]
comment: This term was made obsolete because it was an unnecessary grouping term.
is_obsolete: true
consider: GO:0030613

[Term]
id: GO:0050524
name: coenzyme-B sulfoethylthiotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(methylthio)ethanesulfonate + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate = CoM-S-S-CoB + methane. 2-(methylthio)ethanesulfonate is also known as methyl-CoM; N-(7-mercaptoheptanoyl)threonine 3-O-phosphate is also known as coenzyme B." [EC:2.8.4.1, MetaCyc:2.8.4.1-RXN]
subset: gosubset_prok
synonym: "2-(methylthio)ethanesulfonate:N-(7-thioheptanoyl)-3-O-phosphothreonine S-(2-sulfoethyl)thiotransferase activity" EXACT [EC:2.8.4.1]
synonym: "coenzyme-B sulphoethylthiotransferase activity" EXACT []
synonym: "methyl coenzyme M reductase activity" EXACT [EC:2.8.4.1]
synonym: "methyl-CoM reductase activity" EXACT [EC:2.8.4.1]
xref: EC:2.8.4.1
xref: MetaCyc:METHYL-COM-HTP-RXN
is_a: GO:0050497 ! transferase activity, transferring alkylthio groups

[Term]
id: GO:0050525
name: cutinase activity
namespace: molecular_function
def: "Catalysis of the reaction: cutin + H2O = cutin monomers." [EC:3.1.1.74, MetaCyc:3.1.1.74-RXN]
subset: gosubset_prok
synonym: "cutin hydrolase activity" EXACT [EC:3.1.1.74]
xref: EC:3.1.1.74
xref: MetaCyc:3.1.1.74-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050526
name: poly(3-hydroxybutyrate) depolymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x = 1-5." [EC:3.1.1.75, MetaCyc:3.1.1.75-RXN]
subset: gosubset_prok
synonym: "PHB depolymerase activity" EXACT [EC:3.1.1.75]
synonym: "poly((R)-hydroxyalkanoic acid) depolymerase activity" BROAD [EC:3.1.1.75]
synonym: "poly(3HB) depolymerase activity" EXACT [EC:3.1.1.75]
synonym: "poly(HA(SCL)) depolymerase activity" EXACT [EC:3.1.1.75]
synonym: "poly(HA) depolymerase activity" RELATED [EC:3.1.1.75]
synonym: "poly(HASCL) depolymerase activity" EXACT [EC:3.1.1.75]
synonym: "poly[(R)-3-hydroxybutyrate] hydrolase activity" EXACT [EC:3.1.1.75]
synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.75]
xref: EC:3.1.1.75
xref: MetaCyc:3.1.1.75-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050527
name: poly(3-hydroxyoctanoate) depolymerase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x = 1-5." [EC:3.1.1.76, MetaCyc:3.1.1.76-RXN]
subset: gosubset_prok
synonym: "PHA depolymerase activity" BROAD [EC:3.1.1.76]
synonym: "PHO depolymerase activity" EXACT [EC:3.1.1.76]
synonym: "poly((R)-3-hydroxyoctanoate) hydrolase activity" EXACT [EC:3.1.1.76]
synonym: "poly((R)-hydroxyalkanoic acid) depolymerase activity" BROAD [EC:3.1.1.76]
synonym: "poly(3HO) depolymerase activity" EXACT [EC:3.1.1.76]
synonym: "poly(HA(MCL)) depolymerase activity" EXACT [EC:3.1.1.76]
synonym: "poly(HA) depolymerase activity" BROAD [EC:3.1.1.76]
synonym: "poly(HAMCL) depolymerase activity" EXACT [EC:3.1.1.76]
synonym: "poly[(R)-3-hydroxyoctanoate] hydrolase activity" EXACT [EC:3.1.1.76]
synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.76]
synonym: "poly{oxycarbonyl[(R)-2-pentylethylene]} hydrolase activity" EXACT [EC:3.1.1.76]
xref: EC:3.1.1.76
xref: MetaCyc:3.1.1.76-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050528
name: acyloxyacyl hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid." [EC:3.1.1.77, MetaCyc:3.1.1.77-RXN]
xref: EC:3.1.1.77
xref: MetaCyc:3.1.1.77-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050529
name: polyneuridine-aldehyde esterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + polyneuridine aldehyde = methanol + CO2 + 16-epivellosimine." [EC:3.1.1.78, MetaCyc:3.1.1.78-RXN]
synonym: "PNAE activity" EXACT [EC:3.1.1.78]
synonym: "polyneuridine aldehyde esterase activity" EXACT [EC:3.1.1.78]
synonym: "polyneuridine aldehyde hydrolase (decarboxylating)" EXACT [EC:3.1.1.78]
xref: EC:3.1.1.78
xref: MetaCyc:3.1.1.78-RXN
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0050530
name: glucosylglycerol 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(beta-D-glucosyl)-sn-glycerol-3-phosphate + H2O = 2-(beta-D-glucosyl)-sn-glycerol + phosphate." [EC:3.1.3.69, MetaCyc:3.1.3.69-RXN]
subset: gosubset_prok
synonym: "2-(beta-D-glucosyl)-sn-glycerol-3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.69]
synonym: "salt tolerance protein A" RELATED [EC:3.1.3.69]
synonym: "StpA" RELATED [EC:3.1.3.69]
xref: EC:3.1.3.69
xref: MetaCyc:3.1.3.69-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050531
name: mannosyl-3-phosphoglycerate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2(alpha-D-mannosyl)-3-phosphoglycerate + H2O = 2(alpha-D-mannosyl)-D-glycerate + phosphate." [EC:3.1.3.70, MetaCyc:3.1.3.70-RXN]
subset: gosubset_prok
synonym: "alpha-D-mannosyl-3-phosphoglycerate phosphohydrolase activity" EXACT [EC:3.1.3.70]
xref: EC:3.1.3.70
xref: MetaCyc:3.1.3.70-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050532
name: 2-phosphosulfolactate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-phospho-3-sulfolactate + H2O = 3-sulfolactate + phosphate." [EC:3.1.3.71, MetaCyc:3.1.3.71-RXN]
subset: gosubset_prok
synonym: "(2R)-phosphosulfolactate phosphohydrolase activity" EXACT [EC:3.1.3.71]
synonym: "(R)-2-phospho-3-sulfolactate phosphohydrolase activity" EXACT [EC:3.1.3.71]
synonym: "2-phosphosulpholactate phosphatase activity" EXACT []
synonym: "ComB phosphatase activity" RELATED [EC:3.1.3.71]
xref: EC:3.1.3.71
xref: MetaCyc:R229-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050533
name: 5-phytase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate." [EC:3.1.3.72, MetaCyc:3.1.3.72-RXN]
synonym: "myo-inositol-hexakisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.72]
xref: EC:3.1.3.72
xref: MetaCyc:3.1.3.72-RXN
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0050534
name: 3-deoxyoctulosonase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide." [EC:3.2.1.144, MetaCyc:3.2.1.144-RXN]
synonym: "3-deoxyoctulosonyl-lipopolysaccharide hydrolase activity" EXACT [EC:3.2.1.144]
synonym: "alpha-Kdo-ase activity" EXACT [EC:3.2.1.144]
xref: EC:3.2.1.144
xref: MetaCyc:3.2.1.144-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0050535
name: beta-primeverosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol." [EC:3.2.1.149, MetaCyc:3.2.1.149-RXN]
synonym: "6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside 6-O-(beta-D-xylosyl)-beta-D-glucohydrolase activity" EXACT [EC:3.2.1.149]
synonym: "b-primeverosidase activity" EXACT []
xref: EC:3.2.1.149
xref: MetaCyc:3.2.1.149-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0050536
name: (S)-N-acetyl-1-phenylethylamine hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetylphenylethylamine + H2O = phenylethylamine + acetate." [EC:3.5.1.85, MetaCyc:3.5.1.85-RXN]
synonym: "(S)-N-acetyl-1-phenylethylamine amidohydrolase activity" EXACT [EC:3.5.1.85]
synonym: "(S)-N-acetylphenylethylamine:H2O hydrolase activity" EXACT [EC:3.5.1.85]
xref: EC:3.5.1.85
xref: MetaCyc:3.5.1.85-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050537
name: mandelamide amidase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-mandelamide + H2O = (R)-mandelate + NH3." [EC:3.5.1.86, MetaCyc:3.5.1.86-RXN]
synonym: "mandelamide hydrolase activity" EXACT [EC:3.5.1.86]
synonym: "Pseudomonas mandelamide hydrolase activity" EXACT [EC:3.5.1.86]
xref: EC:3.5.1.86
xref: MetaCyc:3.5.1.86-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050538
name: N-carbamoyl-L-amino-acid hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-carbamoyl-L-2-amino acid (a 2-ureido carboxylate) + H2O = L-2-amino acid + NH3 + CO2." [EC:3.5.1.87, MetaCyc:3.5.1.87-RXN]
subset: gosubset_prok
synonym: "L-carbamoylase activity" EXACT [EC:3.5.1.87]
synonym: "N-carbamoyl-L-amino acid amidohydrolase activity" EXACT [EC:3.5.1.87]
xref: EC:3.5.1.87
xref: MetaCyc:3.5.1.87-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050539
name: maleimide hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: maleimide + H2O = maleamic acid." [EC:3.5.2.16, MetaCyc:3.5.2.16-RXN]
synonym: "cyclic imide hydrolase activity" EXACT [EC:3.5.2.16]
synonym: "cyclic-imide amidohydrolase (decyclicizing)" EXACT [EC:3.5.2.16]
synonym: "cyclic-imide amidohydrolase (decyclizing)" EXACT [EC:3.5.2.16]
synonym: "imidase activity" BROAD [EC:3.5.2.16]
xref: EC:3.5.2.16
xref: MetaCyc:3.5.2.16-RXN
is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

[Term]
id: GO:0050540
name: 2-aminomuconate deaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-aminomuconate + H2O = 4-oxalocrotonate + NH3." [EC:3.5.99.5, MetaCyc:3.5.99.5-RXN]
subset: gosubset_prok
synonym: "2-aminomuconate aminohydrolase activity" EXACT [EC:3.5.99.5]
xref: EC:3.5.99.5
xref: MetaCyc:3.5.99.5-RXN
is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
is_a: GO:0019239 ! deaminase activity

[Term]
id: GO:0050541
name: beta,beta-carotene-9',10'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone." [PMID:11278918]
synonym: "b,b-carotene-9',10'-dioxygenase activity" EXACT []
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0050542
name: icosanoid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "eicosanoid binding" EXACT []
is_a: GO:0005504 ! fatty acid binding

[Term]
id: GO:0050543
name: icosatetraenoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "eicosatetraenoic acid binding" EXACT []
is_a: GO:0050542 ! icosanoid binding

[Term]
id: GO:0050544
name: arachidonic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [GOC:ai]
synonym: "arachidonate binding" EXACT []
is_a: GO:0050543 ! icosatetraenoic acid binding

[Term]
id: GO:0050545
name: sulfopyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-sulfopyruvate = 2-sulfoacetaldehyde + CO2." [EC:4.1.1.79, MetaCyc:4.1.1.79-RXN]
subset: gosubset_prok
synonym: "sulfopyruvate carboxy-lyase (2-sulfoacetaldehyde-forming)" EXACT [EC:4.1.1.79]
synonym: "sulfopyruvate carboxy-lyase activity" EXACT [EC:4.1.1.79]
synonym: "sulphopyruvate decarboxylase activity" EXACT []
xref: EC:4.1.1.79
xref: MetaCyc:R231-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050546
name: 4-hydroxyphenylpyruvate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate = 4-hydroxyphenylacetaldehyde + CO2." [EC:4.1.1.80, MetaCyc:4.1.1.80-RXN]
synonym: "4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)" EXACT [EC:4.1.1.80]
synonym: "4-hydroxyphenylpyruvate carboxy-lyase activity" EXACT [EC:4.1.1.80]
xref: EC:4.1.1.80
xref: MetaCyc:4.1.1.80-RXN
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050547
name: vanillin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA = vanillin + acetyl-CoA." [EC:4.1.2.41, MetaCyc:4.1.2.41-RXN]
synonym: "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA vanillin-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.2.41]
synonym: "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA:vanillin lyase (acetyl-CoA-forming)" EXACT [EC:4.1.2.41]
xref: EC:4.1.2.41
xref: MetaCyc:4.1.2.41-RXN
is_a: GO:0016832 ! aldehyde-lyase activity

[Term]
id: GO:0050548
name: trans-feruloyl-CoA hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA." [EC:4.2.1.101, MetaCyc:4.2.1.101-RXN]
synonym: "4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA hydro-lyase (trans-feruloyl-CoA-forming)" EXACT [EC:4.2.1.101]
synonym: "trans-feruloyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.101]
xref: EC:4.2.1.101
xref: MetaCyc:4.2.1.101-RXN
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050549
name: cyclohexyl-isocyanide hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-cyclohexylformamide = cyclohexyl isocyanide + H2O." [EC:4.2.1.103, MetaCyc:4.2.1.103-RXN]
subset: gosubset_prok
synonym: "isonitrile hydratase activity" EXACT [EC:4.2.1.103]
synonym: "N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming)" EXACT [EC:4.2.1.103]
synonym: "N-cyclohexylformamide hydro-lyase activity" EXACT [EC:4.2.1.103]
xref: EC:4.2.1.103
xref: MetaCyc:4.2.1.103-RXN
xref: UM-BBD_enzymeID:e0638
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0050550
name: pinene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate." [EC:4.2.3.14, MetaCyc:4.2.3.14-RXN]
synonym: "(-)-(1S,5S)-pinene synthase activity" EXACT [EC:4.2.3.14]
synonym: "beta-geraniolene synthase activity" EXACT [EC:4.2.3.14]
synonym: "geranyl-diphosphate diphosphate-lyase (cyclizing, pinene-forming)" EXACT [EC:4.2.3.14]
synonym: "geranyldiphosphate diphosphate lyase (pinene forming)" EXACT [EC:4.2.3.14]
xref: EC:4.2.3.14
xref: MetaCyc:4.2.3.14-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050551
name: myrcene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = myrcene + diphosphate." [EC:4.2.3.15, MetaCyc:4.2.3.15-RXN]
synonym: "geranyl-diphosphate diphosphate-lyase (myrcene-forming) activity" EXACT []
xref: EC:4.2.3.15
xref: MetaCyc:RXN-5110
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050552
name: (4S)-limonene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranyl diphosphate = limonene + diphosphate." [EC:4.2.3.16, MetaCyc:4.2.3.16-RXN]
synonym: "(-)-(4S)-limonene synthase activity" EXACT []
synonym: "4S-(-)-limonene synthase activity" EXACT [EC:4.2.3.16]
synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-(4S)-limonene-forming]" RELATED [EC:4.2.3.16]
synonym: "geranyldiphosphate diphosphate lyase (limonene forming)" EXACT [EC:4.2.3.16]
synonym: "geranyldiphosphate diphosphate lyase [cyclizing, (4S)-limonene-forming]" RELATED [EC:4.2.3.16]
xref: EC:4.2.3.16
xref: MetaCyc:4.2.3.16-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050553
name: taxadiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate = taxa-4,11-diene + diphosphate." [EC:4.2.3.17, MetaCyc:4.2.3.17-RXN]
synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxa-4,11-diene-forming)" EXACT [EC:4.2.3.17]
synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxadiene-forming)" EXACT [EC:4.2.3.17]
synonym: "taxa-4(5),11(12)-diene synthase activity" EXACT [EC:4.2.3.17]
xref: EC:4.2.3.17
xref: MetaCyc:4.2.3.17-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050554
name: abietadiene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate." [EC:4.2.3.18, MetaCyc:4.2.3.18-RXN]
synonym: "(+)-copalyl-diphosphate diphosphate-lyase (cyclizing, (-)-abietadiene-forming)" EXACT [EC:4.2.3.18]
synonym: "abietadiene cyclase activity" EXACT [EC:4.2.3.18]
synonym: "copalyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.18]
xref: EC:4.2.3.18
xref: MetaCyc:4.2.3.18-RXN
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0050555
name: 2-hydroxypropyl-CoM lyase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-[or (S)-]2-hydroxypropyl-CoM = H-S-CoM + (R)-[or (S)-]1,2-epoxypropane." [EC:4.2.99.19, MetaCyc:4.2.99.19-RXN]
subset: gosubset_prok
synonym: "(R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing; epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23]
synonym: "(R)-[or (S)-]2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23]
synonym: "2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)" EXACT [EC:4.4.1.23]
synonym: "coenzyme M-epoxyalkane ligase activity" EXACT [EC:4.4.1.23]
synonym: "EaCoMT activity" EXACT [EC:4.4.1.23]
synonym: "epoxyalkane:2-mercaptoethanesulfonate transferase activity" EXACT [EC:4.4.1.23]
synonym: "epoxyalkane:coenzyme M transferase activity" EXACT [EC:4.4.1.23]
synonym: "epoxyalkane:CoM transferase activity" EXACT [EC:4.4.1.23]
synonym: "epoxyalkyl:CoM transferase activity" EXACT [EC:4.4.1.23]
synonym: "epoxypropane:coenzyme M transferase activity" EXACT [EC:4.4.1.23]
synonym: "epoxypropyl:CoM transferase activity" EXACT [EC:4.4.1.23]
xref: EC:4.4.1.23
xref: MetaCyc:4.2.99.19-RXN
xref: UM-BBD_enzymeID:e0538
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0050556
name: deacetylisoipecoside synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: dopamine + secologanin = deacetylisoipecoside + H2O." [EC:4.3.3.3, MetaCyc:4.3.3.3-RXN]
synonym: "deacetylisoipecoside dopamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.3]
synonym: "deacetylisoipecoside dopamine-lyase activity" EXACT [EC:4.3.3.3]
xref: EC:4.3.3.3
xref: MetaCyc:4.3.3.3-RXN
is_a: GO:0016843 ! amine-lyase activity

[Term]
id: GO:0050557
name: deacetylipecoside synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: dopamine + secologanin = deacetylipecoside + H2O." [EC:4.3.3.4, MetaCyc:4.3.3.4-RXN]
synonym: "deacetylipecoside dopamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.4]
synonym: "deacetylipecoside dopamine-lyase activity" EXACT [EC:4.3.3.4]
xref: EC:4.3.3.4
xref: MetaCyc:4.3.3.4-RXN
is_a: GO:0016843 ! amine-lyase activity

[Term]
id: GO:0050558
name: maltose epimerase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-maltose = beta-maltose." [EC:5.1.3.21, MetaCyc:5.1.3.21-RXN]
synonym: "maltose 1-epimerase activity" EXACT [EC:5.1.3.21]
xref: EC:5.1.3.21
xref: MetaCyc:5.1.3.21-RXN
is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives

[Term]
id: GO:0050559
name: copalyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate = (+)-copalyl diphosphate." [EC:5.5.1.12, MetaCyc:5.5.1.12-RXN]
synonym: "(+)-copalyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.12]
synonym: "diterpene cyclase activity" BROAD []
xref: EC:5.5.1.12
xref: MetaCyc:RXN-4861
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0050560
name: aspartate-tRNA(Asn) ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + pyrophosphate + AMP." [EC:6.1.1.23, MetaCyc:6.1.1.23-RXN]
synonym: "aspartate-tRNAAsn ligase activity" EXACT []
synonym: "L-aspartate:tRNAAsx ligase (AMP-forming)" EXACT [EC:6.1.1.23]
synonym: "nondiscriminating aspartyl-tRNA synthetase activity" RELATED [EC:6.1.1.23]
xref: EC:6.1.1.23
xref: MetaCyc:6.1.1.23-RXN
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0050561
name: glutamate-tRNA(Gln) ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + pyrophosphate + AMP." [EC:6.1.1.24, MetaCyc:6.1.1.24-RXN]
synonym: "glutamate-tRNAGln ligase activity" EXACT []
synonym: "L-glutamate:tRNAGlx ligase (AMP-forming)" EXACT [EC:6.1.1.24]
synonym: "nondiscriminating glutamyl-tRNA synthetase activity" RELATED [EC:6.1.1.24]
xref: EC:6.1.1.24
xref: MetaCyc:6.1.1.24-RXN
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0050562
name: lysine-tRNA(Pyl) ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: tRNA(Pyl) + L-lysine + ATP = L-lysyl-tRNA(Pyl) + pyrophosphate + AMP." [EC:6.1.1.25, MetaCyc:6.1.1.25-RXN]
synonym: "L-lysine:tRNAPyl ligase (AMP-forming)" EXACT [EC:6.1.1.25]
synonym: "lysine-tRNAPyl ligase activity" EXACT []
xref: EC:6.1.1.25
xref: MetaCyc:6.1.1.25-RXN
is_a: GO:0004812 ! aminoacyl-tRNA ligase activity

[Term]
id: GO:0050563
name: trans-feruloyl-CoA synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: ferulic acid + CoASH + ATP = trans-feruloyl-CoA + products of ATP breakdown." [EC:6.2.1.34, MetaCyc:6.2.1.34-RXN]
synonym: "trans-ferulate:CoASH ligase (ATP-hydrolysing)" EXACT [EC:6.2.1.34]
synonym: "trans-feruloyl-CoA synthetase activity" EXACT [EC:6.2.1.34]
xref: EC:6.2.1.34
xref: MetaCyc:6.2.1.34-RXN
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0050564
name: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-2-aminohexanedioate + L-cysteine + L-valine + 3 ATP + H2O = N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate." [EC:6.3.2.26, MetaCyc:6.3.2.26-RXN]
subset: gosubset_prok
synonym: "ACV synthetase activity" BROAD [EC:6.3.2.26]
synonym: "L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting)" EXACT [EC:6.3.2.26]
synonym: "L-alpha-aminoadipyl-cysteinyl-valine synthetase activity" EXACT [EC:6.3.2.26]
synonym: "L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase activity" EXACT [EC:6.3.2.26]
xref: EC:6.3.2.26
xref: MetaCyc:6.3.2.26-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0050565
name: aerobactin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 ATP + citrate + N6-acetyl-N6-hydroxylysine = 4 ADP + 4 phosphate + aerobactin." [EC:6.3.2.27, MetaCyc:6.3.2.27-RXN]
synonym: "citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.27]
synonym: "citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming)" EXACT [EC:6.3.2.27]
xref: EC:6.3.2.27
xref: MetaCyc:6.3.2.27-RXN
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0050566
name: asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP." [EC:6.3.5.6, MetaCyc:6.3.5.6-RXN]
synonym: "Asp-AdT activity" EXACT [EC:6.3.5.6]
synonym: "Asp-tRNA(Asn) amidotransferase activity" EXACT [EC:6.3.5.6]
synonym: "Asp-tRNAAsn amidotransferase activity" EXACT [EC:6.3.5.6]
synonym: "Asp-tRNAAsn:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.6]
synonym: "asparaginyl-tRNA synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.6]
synonym: "aspartyl-tRNA(Asn) amidotransferase activity" EXACT [EC:6.3.5.6]
synonym: "aspartyl-tRNAAsn amidotransferase activity" EXACT [EC:6.3.5.6]
synonym: "aspartyl-tRNAAsn:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.6]
xref: EC:6.3.5.6
xref: MetaCyc:6.3.5.6-RXN
xref: Wikipedia:Asparaginyl-tRNA_synthase_(glutamine-hydrolysing)
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0050567
name: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
alt_id: GO:0008264
alt_id: GO:0017068
def: "Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN]
subset: gosubset_prok
synonym: "Glu-AdT activity" EXACT [EC:6.3.5.-]
synonym: "glu-tRNA(gln) amidotransferase activity" EXACT [EC:6.3.5.-]
synonym: "Glu-tRNA(Gln) amidotransferase activity" EXACT [EC:6.3.5.-]
synonym: "Glu-tRNAGln amidotransferase activity" EXACT [EC:6.3.5.7]
synonym: "Glu-tRNAGln:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.7]
synonym: "glutaminyl-tRNA synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.7]
synonym: "glutamyl-tRNA(Gln) amidotransferase activity" EXACT [EC:6.3.5.-]
synonym: "glutamyl-tRNAGln amidotransferase activity" EXACT [EC:6.3.5.7]
synonym: "glutamyl-tRNAGln:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.7]
xref: EC:6.3.5.-
xref: EC:6.3.5.7
xref: MetaCyc:6.3.5.7-RXN
xref: Wikipedia:Glutaminyl-tRNA_synthase_(glutamine-hydrolysing)
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0050568
name: protein-glutamine glutaminase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3." [EC:3.5.1.44, MetaCyc:CHEBDEAMID-RXN]
synonym: "destabilase activity" EXACT [EC:3.5.1.44]
synonym: "glutaminyl-peptide glutaminase activity" EXACT [EC:3.5.1.44]
synonym: "glutaminylpeptide glutaminase activity" EXACT [EC:3.5.1.44]
synonym: "peptidoglutaminase II activity" RELATED [EC:3.5.1.44]
synonym: "peptidylglutaminase II" RELATED [EC:3.5.1.44]
synonym: "protein-L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.44]
xref: EC:3.5.1.44
xref: MetaCyc:CHEBDEAMID-RXN
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0050569
name: glycolaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: glycolaldehyde + NAD+ + H2O = glycolate + NADH + H+." [EC:1.1.1.262, EC:1.2.1.21, MetaCyc:1.1.1.262-RXN, MetaCyc:GLYCOLALD-DEHYDROG-RXN]
subset: gosubset_prok
synonym: "glycol aldehyde dehydrogenase activity" EXACT [EC:1.2.1.21]
synonym: "glycolaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.21]
xref: EC:1.2.1.21
xref: MetaCyc:GLYCOLALD-DEHYDROG-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050570
name: 4-hydroxythreonine-4-phosphate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-(phosphonooxy)-threonine + NAD+ = 2-amino-3-oxo-4-phosphonooxybutyrate + NADH + H+." [EC:1.1.1.262, MetaCyc:1.1.1.262-RXN]
subset: gosubset_prok
synonym: "4-(phosphohydroxy)-L-threonine dehydrogenase activity" EXACT [EC:1.1.1.262]
synonym: "4-(phosphonooxy)-L-threonine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.262]
synonym: "L-threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262]
synonym: "NAD(+)-dependent threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262]
synonym: "NAD+-dependent threonine 4-phosphate dehydrogenase activity" EXACT [EC:1.1.1.262]
synonym: "PdxA" RELATED [EC:1.1.1.262]
xref: EC:1.1.1.262
xref: MetaCyc:1.1.1.262-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050571
name: 1,5-anhydro-D-fructose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + NADPH + H+." [EC:1.1.1.263, MetaCyc:1.1.1.263-RXN]
synonym: "1,5-anhydro-D-glucitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.263]
synonym: "AF reductase activity" EXACT [EC:1.1.1.263]
xref: EC:1.1.1.263
xref: MetaCyc:1.1.1.263-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050572
name: L-idonate 5-dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+." [EC:1.1.1.264, MetaCyc:1.1.1.264-RXN]
subset: gosubset_prok
synonym: "L-idonate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.264]
xref: EC:1.1.1.264
xref: MetaCyc:1.1.1.264-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050573
name: dTDP-4-dehydro-6-deoxyglucose reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTDP-D-fucose + NADP+ = dTDP-4-dehydro-6-deoxy-D-glucose + NADPH + H+." [EC:1.1.1.266, MetaCyc:1.1.1.266-RXN]
synonym: "dTDP-4-keto-6-deoxyglucose reductase activity" EXACT [EC:1.1.1.266]
synonym: "dTDP-D-fucose:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.266]
xref: EC:1.1.1.266
xref: MetaCyc:1.1.1.266-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050574
name: 2-(R)-hydroxypropyl-CoM dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(R)-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+." [EC:1.1.1.268, MetaCyc:1.1.1.268-RXN]
subset: gosubset_prok
synonym: "2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase activity" EXACT [EC:1.1.1.268]
synonym: "2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.268]
xref: EC:1.1.1.268
xref: MetaCyc:1.1.1.268-RXN
xref: UM-BBD_enzymeID:e0539
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050575
name: 2-(S)-hydroxypropyl-CoM dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-(S)-hydroxypropyl-CoM + NAD+ = 2-oxopropyl-CoM + NADH + H+." [EC:1.1.1.269, MetaCyc:1.1.1.269-RXN]
subset: gosubset_prok
synonym: "2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase activity" EXACT [EC:1.1.1.269]
synonym: "2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.269]
xref: EC:1.1.1.269
xref: MetaCyc:1.1.1.269-RXN
xref: UM-BBD_enzymeID:e0540
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050577
name: GDP-L-fucose synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+." [EC:1.1.1.271, MetaCyc:1.1.1.271-RXN]
subset: gosubset_prok
synonym: "GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase activity" EXACT [EC:1.1.1.271]
synonym: "GDP-fucose synthetase activity" EXACT [EC:1.1.1.271]
synonym: "GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)" EXACT [EC:1.1.1.271]
xref: EC:1.1.1.271
xref: MetaCyc:1.1.1.271-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050578
name: (R)-2-hydroxyacid dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+." [EC:1.1.1.272, MetaCyc:1.1.1.272-RXN]
subset: gosubset_prok
synonym: "(R)-2-hydroxyacid:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.272]
synonym: "(R)-sulfolactate:NAD(P)(+) oxidoreductase activity" EXACT [EC:1.1.1.272]
synonym: "(R)-sulfolactate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.272]
synonym: "L-sulfolactate dehydrogenase activity" EXACT [EC:1.1.1.272]
xref: EC:1.1.1.272
xref: MetaCyc:1.1.1.272-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050579
name: vellosimine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 10-deoxysarpagine + NADP+ = vellosimine + NADPH + H+." [EC:1.1.1.273, MetaCyc:1.1.1.273-RXN]
synonym: "10-deoxysarpagine:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.273]
xref: EC:1.1.1.273
xref: MetaCyc:1.1.1.273-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050580
name: 2,5-didehydrogluconate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+." [EC:1.1.1.274, MetaCyc:1.1.1.274-RXN]
subset: gosubset_prok
synonym: "2,5-diketo-D-gluconate reductase activity" EXACT [EC:1.1.1.274]
synonym: "2-dehydro-D-gluconate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.274]
synonym: "YqhE reductase" RELATED [EC:1.1.1.274]
xref: EC:1.1.1.274
xref: MetaCyc:1.1.1.274-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050581
name: D-mannitol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: mannitol + O2 = mannose + H2O2." [EC:1.1.3.40, MetaCyc:1.1.3.40-RXN]
synonym: "D-arabinitol oxidase activity" RELATED [EC:1.1.3.40]
synonym: "D-arabitol oxidase activity" EXACT [EC:1.1.3.40]
synonym: "mannitol oxidase activity" EXACT [EC:1.1.3.40]
synonym: "mannitol:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.1.3.40]
xref: EC:1.1.3.40
xref: MetaCyc:1.1.3.40-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050582
name: xylitol oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: xylitol + O2 = xylose + H2O2." [EC:1.1.3.41, MetaCyc:1.1.3.41-RXN]
subset: gosubset_prok
synonym: "xylitol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.41]
xref: EC:1.1.3.41
xref: MetaCyc:1.1.3.41-RXN
is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor

[Term]
id: GO:0050583
name: hydrogen dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + H2 = NADPH + H+." [EC:1.12.1.3, MetaCyc:1.12.1.3-RXN]
synonym: "hydrogen:NADP+ oxidoreductase activity" EXACT [EC:1.12.1.3]
synonym: "NADP-linked hydrogenase activity" RELATED [EC:1.12.1.3]
synonym: "NADP-reducing hydrogenase activity" RELATED [EC:1.12.1.3]
xref: EC:1.12.1.3
xref: MetaCyc:1.12.1.3-RXN
is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor

[Term]
id: GO:0050584
name: linoleate 11-lipoxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: linoleate + O2 = (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate." [EC:1.13.11.45, MetaCyc:1.13.11.45-RXN]
synonym: "linoleate dioxygenase activity" EXACT [EC:1.13.11.45]
synonym: "linoleate:oxygen 11S-oxidoreductase activity" EXACT [EC:1.13.11.45]
synonym: "manganese lipoxygenase activity" EXACT [EC:1.13.11.45]
xref: EC:1.13.11.45
xref: MetaCyc:1.13.11.45-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050585
name: 4-hydroxymandelate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2." [EC:1.13.11.46, MetaCyc:1.13.11.46-RXN]
synonym: "4-hydroxyphenylpyruvate dioxygenase II activity" NARROW [EC:1.13.11.46]
synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.13.11.46]
xref: EC:1.13.11.46
xref: MetaCyc:1.13.11.46-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050586
name: 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxy-2-methyl-1H-quinolin-4-one + O2 = N-acetylanthranilate + CO." [EC:1.13.11.48, MetaCyc:1.13.11.48-RXN]
subset: gosubset_prok
synonym: "(1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity" EXACT [EC:1.13.11.48]
synonym: "1H-3-hydroxy-4-oxo quinaldine 2,4-dioxygenase activity" EXACT []
synonym: "1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity" EXACT []
synonym: "3-hydroxy-2-methyl-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)" EXACT [EC:1.13.11.48]
synonym: "3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase activity" EXACT []
xref: EC:1.13.11.48
xref: MetaCyc:1.13.11.48-RXN
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050587
name: chlorite O2-lyase activity
namespace: molecular_function
alt_id: GO:0030065
def: "Catalysis of the reaction: O2 + Cl- = chlorite." [EC:1.13.11.49, MetaCyc:1.13.11.49-RXN]
synonym: "chloride:oxygen oxidoreductase activity" EXACT [EC:1.13.11.49]
synonym: "chlorite dismutase activity" EXACT [EC:1.13.11.49]
xref: EC:1.13.11.49
xref: MetaCyc:1.13.11.49-RXN
xref: UM-BBD_enzymeID:e0610
is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

[Term]
id: GO:0050588
name: apo-beta-carotenoid-14',13'-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8'-apo-beta-carotenol + O2 = 14'-apo-beta-carotenal + H2O." [EC:1.13.12.12, MetaCyc:1.13.12.12-RXN]
synonym: "8'-apo-beta-carotenol:O2 oxidoreductase activity" EXACT [EC:1.13.12.12]
synonym: "apo-b-carotenoid-14',13'-dioxygenase activity" EXACT []
xref: EC:1.13.12.12
xref: MetaCyc:1.13.12.12-RXN
is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

[Term]
id: GO:0050589
name: leucocyanidin oxygenase activity
namespace: molecular_function
alt_id: GO:0045432
def: "Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O." [EC:1.14.11.19, MetaCyc:1.14.11.19-RXN]
synonym: "anthocyanidin synthase activity" RELATED [EC:1.14.11.19]
synonym: "leucoanthocyanidin dioxygenase activity" EXACT [EC:1.14.11.19]
synonym: "leucoanthocyanidin hydroxylase" RELATED [EC:1.14.11.19]
synonym: "leucocyanidin,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.19]
xref: EC:1.14.11.19
xref: MetaCyc:RXN-602
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0050590
name: desacetoxyvindoline 4-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2." [EC:1.14.11.20, MetaCyc:1.14.11.20-RXN]
synonym: "D17H activity" RELATED [EC:1.14.11.20]
synonym: "deacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)" EXACT [EC:1.14.11.20]
synonym: "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4-beta-hydroxylating) activity" EXACT [EC:1.14.11.20]
synonym: "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)" EXACT [EC:1.14.11.20]
synonym: "desacetoxyvindoline-4-hydroxylase activity" EXACT [EC:1.14.11.20]
synonym: "desacetyoxyvindoline-17-hydroxylase activity" EXACT [EC:1.14.11.20]
xref: EC:1.14.11.20
xref: MetaCyc:1.14.11.20-RXN
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0050591
name: quinine 3-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: quinine + NADPH + H+ + O2 = 3-hydroxyquinine + NADP+ + H2O." [EC:1.14.13.67, MetaCyc:1.14.13.67-RXN]
synonym: "nifedipine oxidase activity" EXACT [EC:1.14.13.67]
synonym: "quinine 3-hydroxylase activity" EXACT []
synonym: "quinine,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.67]
xref: EC:1.14.13.67
xref: MetaCyc:1.14.13.67-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050592
name: 4-hydroxyphenylacetaldehyde oxime monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-hydroxyphenylacetaldehyde oxime + NADPH + H+ + O2 = 4-hydroxymandelonitrile + NADP+ + 2 H2O." [EC:1.14.13.68, MetaCyc:1.14.13.68-RXN]
synonym: "(Z)-4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.68]
synonym: "4-hydroxybenzeneacetaldehyde oxime monooxygenase activity" EXACT [EC:1.14.13.68]
synonym: "4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.68]
synonym: "CYP71E1 activity" NARROW [EC:1.14.13.68]
synonym: "cytochrome P450-II-dependent monooxygenase activity" NARROW [EC:1.14.13.68]
synonym: "cytochrome P450II-dependent monooxygenase activity" EXACT [EC:1.14.13.68]
synonym: "NADPH-cytochrome P450 reductase (CYP71E1)" EXACT [EC:1.14.13.68]
xref: EC:1.14.13.68
xref: MetaCyc:1.14.13.68-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050593
name: N-methylcoclaurine 3'-monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-N-methylcoclaurine + NADPH + H+ + O2 = (S)-3'-hydroxy-N-methylcoclaurine + NADP+ + H2O." [EC:1.14.13.71, MetaCyc:1.14.13.71-RXN]
synonym: "(S)-N-methylcoclaurine 3'-hydroxylase activity" EXACT [EC:1.14.13.71]
synonym: "(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.71]
synonym: "cytochrome P450 80B1 activity" EXACT [EC:1.14.13.71]
synonym: "N-methylcoclaurine 3'-hydroxylase activity" EXACT []
xref: EC:1.14.13.71
xref: MetaCyc:1.14.13.71-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050594
name: tabersonine 16-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: tabersonine + NADPH + H+ + O2 = 16-hydroxytabersonine + NADP+ + H2O." [EC:1.14.13.73, MetaCyc:1.14.13.73-RXN]
synonym: "tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating)" EXACT [EC:1.14.13.73]
xref: EC:1.14.13.73
xref: MetaCyc:1.14.13.73-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050595
name: 7-deoxyloganin 7-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-deoxyloganin + NADPH + H+ + O2 = loganin + NADP+ + H2O." [EC:1.14.13.74, MetaCyc:1.14.13.74-RXN]
synonym: "7-deoxyloganin,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.74]
xref: EC:1.14.13.74
xref: MetaCyc:1.14.13.74-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050596
name: vinorine hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: vinorine + NADPH + H+ + O2 = vomilenine + NADP+ + H2O." [EC:1.14.13.75, MetaCyc:1.14.13.75-RXN]
synonym: "vinorine,NADPH:oxygen oxidoreductase (21alpha-hydroxylating)" EXACT [EC:1.14.13.75]
xref: EC:1.14.13.75
xref: MetaCyc:1.14.13.75-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050597
name: taxane 10-beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + taxa-4(20),11-dien-5-alpha-yl acetate = H2O + NADP+ + 10-beta-hydroxytaxa-4(20),11-dien-5-alpha-yl acetate." [EC:1.14.13.76, MetaCyc:1.14.13.76-RXN]
synonym: "5-alpha-taxadienol-10-beta-hydroxylase activity" EXACT [EC:1.14.13.76]
synonym: "taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating)" EXACT [EC:1.14.13.76]
synonym: "taxane 10b-hydroxylase activity" EXACT []
synonym: "taxane 10beta-hydroxylase activity" EXACT [EC:1.14.13.76]
xref: EC:1.14.13.76
xref: MetaCyc:1.14.13.76-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050598
name: taxane 13-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + taxa-4(20),11-dien-5-alpha-ol = H2O + NADP+ + taxa-4(20),11-dien-5-alpha,13-alpha-diol." [EC:1.14.13.77, MetaCyc:1.14.13.77-RXN]
synonym: "taxa-4(20),11-dien-5alpha-ol,NADPH:oxygen oxidoreductase (13alpha-hydroxylating)" EXACT [EC:1.14.13.77]
synonym: "taxane 13a-hydroxylase activity" EXACT []
synonym: "taxane 13alpha-hydroxylase activity" EXACT [EC:1.14.13.77]
xref: EC:1.14.13.77
xref: MetaCyc:1.14.13.77-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0050599
name: deacetoxycephalosporin-C synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: penicillin-N + 2-oxoglutarate + O2 = deacetoxycephalosporin C + succinate + CO2 + H2O." [EC:1.14.20.1, MetaCyc:1.14.20.1-RXN]
subset: gosubset_prok
synonym: "DAOC synthase activity" EXACT [EC:1.14.20.1]
synonym: "DAOCS activity" EXACT [EC:1.14.20.1]
synonym: "penicillin N expandase activity" RELATED [EC:1.14.20.1]
synonym: "penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding)" EXACT [EC:1.14.20.1]
xref: EC:1.14.20.1
xref: MetaCyc:1.14.20.1-RXN
is_a: GO:0050498 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated

[Term]
id: GO:0050600
name: myristoyl-CoA 11-(E) desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (E)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O." [EC:1.14.99.31, MetaCyc:1.14.99.31-RXN]
synonym: "n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(E) desaturating]" RELATED [EC:1.14.99.31]
synonym: "n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(E) desaturating]" RELATED [EC:1.14.99.31]
xref: EC:1.14.99.31
xref: MetaCyc:1.14.99.31-RXN
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050601
name: myristoyl-CoA 11-(Z) desaturase activity
namespace: molecular_function
def: "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (Z)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O." [EC:1.14.99.32, MetaCyc:1.14.99.32-RXN]
synonym: "n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(Z) desaturating]" RELATED [EC:1.14.99.32]
synonym: "n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(Z) desaturating]" RELATED [EC:1.14.99.32]
xref: EC:1.14.99.32
xref: MetaCyc:1.14.99.32-RXN
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050602
name: monoprenyl isoflavone epoxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + NADPH + H+ + 7-O-methylluteone = H2O + NADP+ + dihydrofurano derivatives." [EC:1.14.99.34, MetaCyc:1.14.99.34-RXN]
synonym: "7-O-methylluteone,NADPH:O2 oxidoreductase activity" EXACT [EC:1.14.99.34]
synonym: "7-O-methylluteone:O2 oxidoreductase activity" EXACT [EC:1.14.99.34]
synonym: "monoprenyl isoflavone monooxygenase activity" EXACT [EC:1.14.99.34]
xref: EC:1.14.99.34
xref: MetaCyc:1.14.99.34-RXN
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050603
name: thiophene-2-carbonyl-CoA monooxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: thiophene-2-carbonyl-CoA + AH2 + O2 = 5-hydroxythiophene-2-carbonyl-CoA + A + H2O." [EC:1.14.99.35, MetaCyc:1.14.99.35-RXN]
synonym: "thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.35]
synonym: "thiophene-2-carboxyl-CoA dehydrogenase activity" EXACT [EC:1.14.99.35]
synonym: "thiophene-2-carboxyl-CoA hydroxylase activity" EXACT [EC:1.14.99.35]
synonym: "thiophene-2-carboxyl-CoA monooxygenase activity" EXACT [EC:1.14.99.35]
xref: EC:1.14.99.35
xref: MetaCyc:1.14.99.35-RXN
xref: UM-BBD_enzymeID:e0775
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050604
name: taxadiene 5-alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O2 + donor-H2 + taxa-4,11-diene = H2O + acceptor + taxa-4(20),11-dien-5-alpha-ol." [EC:1.14.99.37, MetaCyc:1.14.99.37-RXN]
synonym: "taxa-4,11-diene,hydrogen-donor:oxygen oxidoreductase (5alpha-hydroxylating)" EXACT [EC:1.14.99.37]
synonym: "taxadiene 5a-hydroxylase activity" EXACT []
synonym: "taxadiene 5alpha-hydroxylase activity" EXACT [EC:1.14.99.37]
xref: EC:1.14.99.37
xref: MetaCyc:1.14.99.37-RXN
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0050605
name: superoxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin." [EC:1.15.1.2, MetaCyc:1.15.1.2-RXN]
subset: gosubset_prok
synonym: "desulfoferrodoxin activity" RELATED [EC:1.15.1.2]
synonym: "neelaredoxin activity" RELATED [EC:1.15.1.2]
synonym: "rubredoxin:superoxide oxidoreductase activity" EXACT [EC:1.15.1.2]
xref: EC:1.15.1.2
xref: MetaCyc:1.15.1.2-RXN
is_a: GO:0016209 ! antioxidant activity
is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor

[Term]
id: GO:0050606
name: 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + NADP+ = 4-carboxy-2-hydroxy-cis,cis-muconate + NADPH + H+." [EC:1.2.1.45, MetaCyc:1.2.1.45-RXN]
synonym: "2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.45]
synonym: "4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ 6-oxidoreductase activity" EXACT [EC:1.2.1.45]
synonym: "4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.45]
synonym: "alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.45]
xref: EC:1.2.1.45
xref: MetaCyc:1.2.1.45-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050607
name: mycothiol-dependent formaldehyde dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+." [EC:1.2.1.66, MetaCyc:1.2.1.66-RXN]
subset: gosubset_prok
synonym: "formaldehyde:NAD+ oxidoreductase (mycothiol-formylating)" EXACT [EC:1.2.1.66]
synonym: "NAD/factor-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.2.1.66]
xref: EC:1.2.1.66
xref: MetaCyc:1.2.1.66-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050608
name: vanillin dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: vanillin + NAD+ + H2O = vanillate + NADH + H+." [EC:1.2.1.67, MetaCyc:1.2.1.67-RXN]
synonym: "vanillin:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.67]
xref: EC:1.2.1.67
xref: MetaCyc:1.2.1.67-RXN
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050609
name: phosphonate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphonate + NAD+ + H2O = phosphate + NADH + H+." [EC:1.20.1.1, MetaCyc:1.20.1.1-RXN]
subset: gosubset_prok
synonym: "NAD-dependent phosphite dehydrogenas activity" EXACT [EC:1.20.1.1]
synonym: "NAD:phosphite oxidoreductase activity" EXACT [EC:1.20.1.1]
synonym: "phosphite dehydrogenase activity" EXACT [EC:1.20.1.1]
synonym: "phosphonate:NAD+ oxidoreductase activity" EXACT [EC:1.20.1.1]
xref: EC:1.20.1.1
xref: MetaCyc:1.20.1.1-RXN
xref: UM-BBD_enzymeID:e0658
is_a: GO:0050499 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor

[Term]
id: GO:0050610
name: methylarsonate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: reduced glutathione + methylarsonate = oxidized glutathione + methylarsonite." [EC:1.20.4.2, MetaCyc:1.20.4.2-RXN]
synonym: "gluthathione:methylarsonate oxidoreductase activity" EXACT [EC:1.20.4.2]
synonym: "MMA(V) reductase activity" EXACT [EC:1.20.4.2]
xref: EC:1.20.4.2
xref: MetaCyc:1.20.4.2-RXN
xref: UM-BBD_enzymeID:e0528
is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulfide as acceptor

[Term]
id: GO:0050611
name: arsenate reductase (azurin) activity
namespace: molecular_function
def: "Catalysis of the reaction: azurin(ox) + H2O + arsenite = azurin(red) + arsenate." [EC:1.20.98.1, MetaCyc:1.20.98.1-RXN]
subset: gosubset_prok
synonym: "arsenite:azurin oxidoreductase activity" EXACT [EC:1.20.98.1]
xref: EC:1.20.98.1
xref: MetaCyc:1.20.98.1-RXN
is_a: GO:0050522 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors

[Term]
id: GO:0050612
name: arsenate reductase (donor) activity
namespace: molecular_function
def: "Catalysis of the reaction: acceptor + arsenite = donor-H2 + arsenate." [EC:1.20.99.1, MetaCyc:1.20.99.1-RXN]
synonym: "arsenate:(acceptor) oxidoreductase activity" EXACT [EC:1.20.99.1]
synonym: "arsenate:acceptor oxidoreductase activity" EXACT [EC:1.20.99.1]
xref: EC:1.20.99.1
xref: MetaCyc:1.20.99.1-RXN
is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors

[Term]
id: GO:0050613
name: delta14-sterol reductase activity
namespace: molecular_function
alt_id: GO:0000251
def: "Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol." [EC:1.3.1.70, MetaCyc:1.3.1.70-RXN]
comment: Note that zymosterol is cholesta-8,24-dien-3-ol.
synonym: "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity" EXACT [EC:1.3.1.70]
synonym: "C-14 sterol reductase activity" EXACT []
synonym: "D14-sterol reductase activity" EXACT []
synonym: "sterol C-14 reductase activity" EXACT []
synonym: "sterol C14-reductase activity" EXACT [EC:1.3.1.70]
xref: EC:1.3.1.70
xref: MetaCyc:1.3.1.70-RXN
xref: Reactome:81517 "delta14-sterol reductase activity"
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050614
name: delta24-sterol reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol." [EC:1.3.1.72, MetaCyc:1.3.1.72-RXN]
synonym: "D24-sterol reductase activity" EXACT []
synonym: "lanosterol Delta(24)-reductase activity" NARROW [EC:1.3.1.72]
synonym: "lanosterol delta24-reductase activity" EXACT [EC:1.3.1.72]
synonym: "sterol:NADP+ delta24-oxidoreductase activity" EXACT [EC:1.3.1.72]
xref: EC:1.3.1.72
xref: MetaCyc:1.3.1.72-RXN
xref: Reactome:81519 "delta24-sterol reductase activity"
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050615
name: 1,2-dihydrovomilenine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 17-O-acetylnorajmaline + NADP+ = 1,2-dihydrovomilenine + NADPH + H+." [EC:1.3.1.73, MetaCyc:1.3.1.73-RXN]
synonym: "17-O-acetylnorajmaline:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.73]
xref: EC:1.3.1.73
xref: MetaCyc:1.3.1.73-RXN
is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050616
name: secologanin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O." [EC:1.3.3.9, MetaCyc:1.3.3.9-RXN]
synonym: "loganin:oxygen oxidoreductase (ring-cleaving)" EXACT [EC:1.3.3.9]
xref: EC:1.3.3.9
xref: MetaCyc:1.3.3.9-RXN
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0050617
name: 15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.2, MetaCyc:1.3.7.2-RXN]
subset: gosubset_prok
synonym: "PebA" RELATED [EC:1.3.7.2]
xref: EC:1.3.7.2
xref: MetaCyc:1.3.7.2-RXN
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0050618
name: phycoerythrobilin:ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin." [EC:1.3.7.3, MetaCyc:1.3.7.3-RXN]
subset: gosubset_prok
synonym: "(3Z)-phycoerythrobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.3]
synonym: "PebB" RELATED [EC:1.3.7.3]
xref: EC:1.3.7.3
xref: MetaCyc:1.3.7.3-RXN
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0050619
name: phytochromobilin:ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.4, MetaCyc:1.3.7.4-RXN]
synonym: "(3Z)-phytochromobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.4]
synonym: "HY2" RELATED [EC:1.3.7.4]
synonym: "P-Phi-B synthase activity" RELATED [EC:1.3.7.4]
synonym: "PFB synthase activity" EXACT [EC:1.3.7.4]
synonym: "phytochromobilin synthase activity" EXACT [EC:1.3.7.4]
synonym: "PPhiB synthase activity" EXACT [EC:1.3.7.4]
xref: EC:1.3.7.4
xref: MetaCyc:1.3.7.4-RXN
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0050620
name: phycocyanobilin:ferredoxin oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.5, MetaCyc:1.3.7.5-RXN]
subset: gosubset_prok
synonym: "(3Z)-phycocyanobilin:ferredoxin oxidoreductase activity" EXACT [EC:1.3.7.5]
xref: EC:1.3.7.5
xref: MetaCyc:1.3.7.5-RXN
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0050621
name: tryptophan alpha,beta-oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + O2 = alpha,beta-didehydrotryptophan + H2O2." [EC:1.3.3.10, MetaCyc:1.4.3.17-RXN]
comment: Note that this was EC:1.4.3.17.
synonym: "L-tryptophan 2',3'-oxidase activity" EXACT [EC:1.3.3.10]
synonym: "L-tryptophan alpha,beta-dehydrogenase activity" EXACT [EC:1.3.3.10]
synonym: "L-tryptophan:oxygen alpha,beta-oxidoreductase activity" EXACT [EC:1.3.3.10]
synonym: "tryptophan a,b-oxidase activity" EXACT []
xref: EC:1.3.3.10
xref: MetaCyc:1.4.3.17-RXN
is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor

[Term]
id: GO:0050622
name: glycine dehydrogenase (cyanide-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2." [EC:1.4.99.5, MetaCyc:1.4.99.5-RXN]
synonym: "glycine:acceptor oxidoreductase (hydrogen-cyanide-forming)" EXACT [EC:1.4.99.5]
synonym: "HCN synthase activity" EXACT [EC:1.4.99.5]
synonym: "hydrogen cyanide synthase activity" EXACT [EC:1.4.99.5]
xref: EC:1.4.99.5
xref: MetaCyc:1.4.99.5-RXN
is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors

[Term]
id: GO:0050623
name: berberine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-canadine + 2 NADP+ = berberine + 2 NADPH + H+." [EC:1.5.1.31, MetaCyc:1.5.1.31-RXN]
synonym: "(R)-canadine synthase activity" EXACT [EC:1.5.1.31]
synonym: "(R)-tetrahydroberberine:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.31]
xref: EC:1.5.1.31
xref: MetaCyc:1.5.1.31-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050624
name: vomilenine reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 1,2-dihydrovomilenine + NADP+ = vomilenine + NADPH + H+." [EC:1.5.1.32, MetaCyc:1.5.1.32-RXN]
synonym: "1,2-dihydrovomilenine:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.32]
xref: EC:1.5.1.32
xref: MetaCyc:1.5.1.32-RXN
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050625
name: 2-hydroxy-1,4-benzoquinone reductase activity
namespace: molecular_function
alt_id: GO:0018540
def: "Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + NADH + H+ = NAD+ + 1,2,4-benzenetriol." [EC:1.6.5.7, MetaCyc:1.6.5.7-RXN]
synonym: "1,2,4-trihydroxybenzene:NAD oxidoreductase activity" EXACT [EC:1.6.5.7]
synonym: "1,2,4-trihydroxybenzene:NAD+ oxidoreductase activity" EXACT [EC:1.6.5.7]
synonym: "2-hydroxy-1,4-benzoquinone:NADH oxidoreductase activity" EXACT [EC:1.6.5.7]
synonym: "hydroxybenzoquinone reductase activity" EXACT [EC:1.6.5.-]
synonym: "NADH:2-hydroxy-1,4-benzoquinone oxidoreductase activity" EXACT [EC:1.6.5.7]
xref: EC:1.6.5.-
xref: EC:1.6.5.7
xref: MetaCyc:1.6.5.7-RXN
xref: UM-BBD_enzymeID:e0424
is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor

[Term]
id: GO:0050626
name: trimethylamine-N-oxide reductase (cytochrome c) activity
namespace: molecular_function
def: "Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+ ." [EC:1.7.2.3, MetaCyc:1.7.2.3-RXN]
subset: gosubset_prok
synonym: "TMAO reductase activity" EXACT [EC:1.7.2.3]
synonym: "TOR activity" EXACT [EC:1.7.2.3]
synonym: "trimethylamine:cytochrome c oxidoreductase activity" EXACT [EC:1.7.2.3]
xref: EC:1.7.2.3
xref: MetaCyc:1.7.2.3-RXN
xref: Wikipedia:Trimethylamine_N-oxide_reductase
is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor

[Term]
id: GO:0050627
name: mycothione reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione." [EC:1.8.1.15, MetaCyc:1.8.1.15-RXN]
synonym: "mycothiol-disulfide reductase activity" EXACT [EC:1.8.1.15]
synonym: "mycothiol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.8.1.15]
xref: EC:1.8.1.15
xref: MetaCyc:1.8.1.15-RXN
is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050628
name: 2-oxopropyl-CoM reductase (carboxylating) activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-mercaptoethanesulfonate + acetoacetate + NADP+ = 2-(2-oxopropylthio)ethanesulfonate + CO2 + NADPH + H+." [EC:1.8.1.5, MetaCyc:1.8.1.5-RXN]
subset: gosubset_prok
synonym: "2-KPCC activity" EXACT [EC:1.8.1.5]
synonym: "2-mercaptoethanesulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.8.1.5]
synonym: "NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase activity" EXACT [EC:1.8.1.5]
synonym: "NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase activity" EXACT [EC:1.8.1.5]
xref: EC:1.8.1.5
xref: MetaCyc:1.8.1.5-RXN
xref: UM-BBD_enzymeID:e0541
is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor

[Term]
id: GO:0050629
name: tetrachloroethene reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor." [EC:1.97.1.8, MetaCyc:1.97.1.8-RXN]
subset: gosubset_prok
synonym: "acceptor:trichloroethene oxidoreductase (chlorinating)" EXACT [EC:1.97.1.8]
synonym: "tetrachloroethene reductase activity" EXACT [EC:1.97.1.8]
xref: EC:1.97.1.8
xref: MetaCyc:1.97.1.8-RXN
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0050630
name: (iso)eugenol O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol." [EC:2.1.1.146, MetaCyc:2.1.1.146-RXN]
synonym: "isoeugenol O-methyltransferase activity" EXACT []
synonym: "S-adenosyl-L-methionine:isoeugenol O-methyltransferase activity" EXACT [EC:2.1.1.146]
xref: EC:2.1.1.146
xref: MetaCyc:2.1.1.146-RXN
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0050631
name: corydaline synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + palmatine + 2 NADPH + H+ = S-adenosyl-L-homocysteine + corydaline + 2 NADP+." [EC:2.1.1.147, MetaCyc:2.1.1.147-RXN]
synonym: "S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase activity" EXACT [EC:2.1.1.147]
xref: EC:2.1.1.147
xref: MetaCyc:2.1.1.147-RXN
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0050632
name: propionyl-CoA C2-trimethyltridecanoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA." [EC:2.3.1.154, MetaCyc:2.3.1.154-RXN]
synonym: "3-oxopristanoyl-CoA hydrolase activity" EXACT [EC:2.3.1.154]
synonym: "3-oxopristanoyl-CoA thiolase activity" EXACT [EC:2.3.1.154]
synonym: "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase activity" EXACT [EC:2.3.1.154]
synonym: "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA C2-4,8,12-trimethyltridecanoyltransferase activity" EXACT [EC:2.3.1.154]
synonym: "oxopristanoyl-CoA thiolase activity" EXACT [EC:2.3.1.154]
synonym: "peroxisomal 3-oxoacyl coenzyme A thiolase" NARROW [EC:2.3.1.154]
synonym: "peroxisome sterol carrier protein thiolase" NARROW [EC:2.3.1.154]
synonym: "propionyl-CoA C(2)-trimethyltridecanoyltransferase activity" EXACT []
synonym: "SCPx" RELATED [EC:2.3.1.154]
synonym: "sterol carrier protein" RELATED [EC:2.3.1.154]
xref: EC:2.3.1.154
xref: MetaCyc:2.3.1.154-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050633
name: acetyl-CoA C-myristoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA." [EC:2.3.1.155, MetaCyc:2.3.1.155-RXN]
synonym: "3-oxopalmitoyl-CoA hydrolase activity" EXACT [EC:2.3.1.155]
synonym: "3-oxopalmitoyl-CoA-CoA acetyltransferase activity" EXACT [EC:2.3.1.155]
synonym: "myristoyl-CoA C-acetyltransferase activity" EXACT [EC:2.3.1.155]
synonym: "myristoyl-CoA:acetyl-CoA C-myristoyltransferase activity" EXACT [EC:2.3.1.155]
xref: EC:2.3.1.155
xref: MetaCyc:2.3.1.155-RXN
is_a: GO:0016408 ! C-acyltransferase activity
is_a: GO:0019107 ! myristoyltransferase activity

[Term]
id: GO:0050634
name: phloroisovalerophenone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one." [EC:2.3.1.156, MetaCyc:2.3.1.156-RXN]
synonym: "3-methyl-1-(trihydroxyphenyl)butan-1-one synthase activity" EXACT [EC:2.3.1.156]
synonym: "isovaleryl-CoA:malonyl-CoA acyltransferase activity" EXACT [EC:2.3.1.156]
synonym: "valerophenone synthase activity" EXACT [EC:2.3.1.156]
xref: EC:2.3.1.156
xref: MetaCyc:2.3.1.156-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050635
name: acridone synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3 malonyl-CoA + N-methylanthraniloyl-CoA = 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2." [EC:2.3.1.159, MetaCyc:2.3.1.159-RXN]
synonym: "malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)" EXACT [EC:2.3.1.159]
xref: EC:2.3.1.159
xref: MetaCyc:2.3.1.159-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050636
name: vinorine synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + 16-epivellosimine = CoA + vinorine." [EC:2.3.1.160, MetaCyc:2.3.1.160-RXN]
synonym: "acyl-CoA:16-epivellosimine O-acetyltransferase (cyclizing)" EXACT [EC:2.3.1.160]
xref: EC:2.3.1.160
xref: MetaCyc:2.3.1.160-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050637
name: lovastatin nonaketide synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 11 H+ + S-adenosyl-L-methionine = dihydromonacolin L + 9 CoA + 8 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O." [EC:2.3.1.161, MetaCyc:2.3.1.161-RXN]
synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)" EXACT [EC:2.3.1.161]
xref: EC:2.3.1.161
xref: MetaCyc:2.3.1.161-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050638
name: taxadien-5-alpha-ol O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5-alpha-ol = CoA + taxa-4(20),11-dien-5-alpha-yl acetate." [EC:2.3.1.162, MetaCyc:2.3.1.162-RXN]
synonym: "acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase activity" EXACT [EC:2.3.1.162]
synonym: "acetyl coenzyme A:taxa-4(20),11(12)-dien-5-alpha-ol O-acetyl transferase activity" EXACT [EC:2.3.1.162]
synonym: "acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase activity" EXACT [EC:2.3.1.162]
synonym: "taxa-4(20),11(12)-dien-5alpha-ol-O-acetyltransferase activity" EXACT [EC:2.3.1.162]
synonym: "taxadien-5a-ol O-acetyltransferase activity" EXACT []
synonym: "taxadien-5alpha-ol O-acetyltransferase activity" EXACT [EC:2.3.1.162]
synonym: "taxadienol acetyltransferase activity" EXACT [EC:2.3.1.162]
xref: EC:2.3.1.162
xref: MetaCyc:2.3.1.162-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050639
name: 10-hydroxytaxane O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + 10-desacetyltaxuyunnanin C = CoA + taxuyunnanin C." [EC:2.3.1.163, MetaCyc:2.3.1.163-RXN]
synonym: "acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase activity" EXACT [EC:2.3.1.163]
synonym: "acetyl coenzyme A:10-hydroxytaxane O-acetyltransferase activity" EXACT [EC:2.3.1.163]
synonym: "acetyl-CoA:taxan-10beta-ol O-acetyltransferase" BROAD [EC:2.3.1.163]
xref: EC:2.3.1.163
xref: MetaCyc:2.3.1.163-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050640
name: isopenicillin-N N-acyltransferase activity
namespace: molecular_function
alt_id: GO:0042319
alt_id: GO:0045440
def: "Catalysis of the reaction: phenylacetyl-CoA + isopenicillin-N + H2O = CoA + penicillin-G + L-2-aminohexanedioate." [EC:2.3.1.164, MetaCyc:2.3.1.164-RXN]
synonym: "acyl-CoA:isopenicillin N N-acyltransferase activity" EXACT [EC:2.3.1.164]
synonym: "acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase activity" EXACT [EC:2.3.1.164]
synonym: "acyl-coenzyme A:isopenicillin N acyltransferase activity" EXACT [EC:2.3.1.164]
synonym: "isopenicillin N:acyl-CoA acyltransferase activity" EXACT [EC:2.3.1.164]
synonym: "isopenicillin-N acyltransferase activity" EXACT []
xref: EC:2.3.1.164
xref: MetaCyc:2.3.1.164-RXN
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0050641
name: 6-methylsalicylic acid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + 3 malonyl-CoA + NADPH + H+ = 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+." [EC:2.3.1.165, MetaCyc:2.3.1.165-RXN]
synonym: "6-MSAS activity" EXACT [EC:2.3.1.165]
synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)" EXACT [EC:2.3.1.165]
synonym: "MSAS activity" EXACT [EC:2.3.1.165]
xref: EC:2.3.1.165
xref: MetaCyc:2.3.1.165-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050642
name: 2-alpha-hydroxytaxane 2-O-benzoyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III = CoA + 10-deacetylbaccatin III." [EC:2.3.1.166, MetaCyc:2.3.1.166-RXN]
synonym: "2-debenzoyl-7,13-diacetylbaccatin III-2-O-benzoyl transferase activity" EXACT [EC:2.3.1.166]
synonym: "2a-hydroxytaxane 2-O-benzoyltransferase activity" EXACT []
synonym: "2alpha-hydroxytaxane 2-O-benzoyltransferase activity" EXACT [EC:2.3.1.166]
synonym: "benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase activity" EXACT [EC:2.3.1.166]
synonym: "benzoyl-CoA:taxane 2-alpha-O-benzoyltransferase activity" EXACT [EC:2.3.1.166]
synonym: "benzoyl-CoA:taxane 2alpha-O-benzoyltransferase activity" EXACT [EC:2.3.1.166]
xref: EC:2.3.1.166
xref: MetaCyc:2.3.1.166-RXN
is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups

[Term]
id: GO:0050643
name: 10-deacetylbaccatin III 10-O-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + 10-deacetylbaccatin III = CoA + baccatin III." [EC:2.3.1.167, MetaCyc:2.3.1.167-RXN]
synonym: "acetyl-CoA:taxan-10beta-ol O-acetyltransferase" BROAD [EC:2.3.1.167]
xref: EC:2.3.1.167
xref: MetaCyc:2.3.1.167-RXN
is_a: GO:0016413 ! O-acetyltransferase activity

[Term]
id: GO:0050644
name: cis-p-coumarate glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: cis-p-coumarate + UDP-D-glucose = UDP + 4'-O-beta-D-glucosyl-cis-p-coumarate." [EC:2.4.1.209, MetaCyc:2.4.1.209-RXN]
synonym: "UDP-glucose:cis-p-coumarate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.209]
xref: EC:2.4.1.209
xref: MetaCyc:2.4.1.209-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050645
name: limonoid glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP." [EC:2.4.1.210]
synonym: "LGTase activity" EXACT [EC:2.4.1.210]
synonym: "limonoid UDP-glucosyltransferase activity" EXACT [EC:2.4.1.210]
synonym: "uridine diphosphoglucose-limonoid glucosyltransferase activity" EXACT [EC:2.4.1.210]
xref: EC:2.4.1.210
xref: MetaCyc:2.4.1.210-RXN
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0050646
name: 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai]
synonym: "5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT []
is_a: GO:0050543 ! icosatetraenoic acid binding

[Term]
id: GO:0050647
name: 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai]
synonym: "5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT []
is_a: GO:0050543 ! icosatetraenoic acid binding

[Term]
id: GO:0050648
name: 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai]
synonym: "5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT []
is_a: GO:0050543 ! icosatetraenoic acid binding

[Term]
id: GO:0050649
name: testosterone 6-beta-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O." [GOC:ai, PMID:11726664]
synonym: "testosterone 6b-hydroxylase activity" EXACT []
is_a: GO:0008395 ! steroid hydroxylase activity

[Term]
id: GO:0050650
name: chondroitin sulfate proteoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]
subset: gosubset_prok
synonym: "chondroitin sulfate proteoglycan anabolism" EXACT []
synonym: "chondroitin sulfate proteoglycan biosynthesis" EXACT []
synonym: "chondroitin sulfate proteoglycan formation" EXACT []
synonym: "chondroitin sulfate proteoglycan synthesis" EXACT []
synonym: "chondroitin sulphate proteoglycan biosynthesis" EXACT []
synonym: "chondroitin sulphate proteoglycan biosynthetic process" EXACT []
is_a: GO:0030166 ! proteoglycan biosynthetic process
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0050654 ! chondroitin sulfate proteoglycan metabolic process

[Term]
id: GO:0050651
name: dermatan sulfate proteoglycan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:ai]
subset: gosubset_prok
synonym: "chondroitin sulfate B proteoglycan biosynthesis" EXACT []
synonym: "chondroitin sulfate B proteoglycan biosynthetic process" EXACT []
synonym: "dermatan sulfate proteoglycan anabolism" EXACT []
synonym: "dermatan sulfate proteoglycan biosynthesis" EXACT []
synonym: "dermatan sulfate proteoglycan formation" EXACT []
synonym: "dermatan sulfate proteoglycan synthesis" EXACT []
synonym: "dermatan sulphate proteoglycan biosynthesis" EXACT []
synonym: "dermatan sulphate proteoglycan biosynthetic process" EXACT []
is_a: GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process
is_a: GO:0050655 ! dermatan sulfate proteoglycan metabolic process

[Term]
id: GO:0050652
name: dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
namespace: biological_process
def: "The elongation of dermatan sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of dermatan sulfate." [GOC:ai, PMID:11788602]
subset: gosubset_prok
synonym: "chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT []
synonym: "chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT []
synonym: "chondroitin sulfate B proteoglycan chain elongation" EXACT []
synonym: "dermatan sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT []
synonym: "dermatan sulfate proteoglycan chain elongation" EXACT []
synonym: "dermatan sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT []
synonym: "dermatan sulfate proteoglycan formation, polysaccharide chain formation" EXACT []
synonym: "dermatan sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT []
synonym: "dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT []
synonym: "dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
relationship: part_of GO:0050651 ! dermatan sulfate proteoglycan biosynthetic process

[Term]
id: GO:0050653
name: chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
namespace: biological_process
def: "The elongation of chondroitin sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of chondroitin sulfate." [GOC:ai, PMID:11788602]
subset: gosubset_prok
synonym: "chondroitin sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT []
synonym: "chondroitin sulfate proteoglycan chain elongation" EXACT []
synonym: "chondroitin sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT []
synonym: "chondroitin sulfate proteoglycan formation, polysaccharide chain formation" EXACT []
synonym: "chondroitin sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT []
synonym: "chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT []
synonym: "chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
relationship: part_of GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process

[Term]
id: GO:0050654
name: chondroitin sulfate proteoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]
subset: gosubset_prok
synonym: "chondroitin sulfate proteoglycan metabolism" EXACT []
synonym: "chondroitin sulphate proteoglycan metabolic process" EXACT []
synonym: "chondroitin sulphate proteoglycan metabolism" EXACT []
is_a: GO:0006029 ! proteoglycan metabolic process
is_a: GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0050655
name: dermatan sulfate proteoglycan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:ai]
subset: gosubset_prok
synonym: "chondroitin sulfate B proteoglycan metabolic process" EXACT []
synonym: "chondroitin sulfate B proteoglycan metabolism" EXACT []
synonym: "dermatan sulfate proteoglycan metabolism" EXACT []
synonym: "dermatan sulphate proteoglycan metabolic process" EXACT []
synonym: "dermatan sulphate proteoglycan metabolism" EXACT []
is_a: GO:0050654 ! chondroitin sulfate proteoglycan metabolic process

[Term]
id: GO:0050656
name: 3'-phosphoadenosine 5'-phosphosulfate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [GOC:ai]
synonym: "3'-phosphoadenosine 5'-phosphosulphate binding" EXACT []
synonym: "3'-phosphoadenylyl-sulfate binding" EXACT []
synonym: "adenosine 3'-phosphate 5'-phosphosulfate binding" EXACT []
synonym: "PAPS binding" EXACT []
synonym: "phosphoadenosine phosphosulfate binding" EXACT []
is_a: GO:0030554 ! adenyl nucleotide binding

[Term]
id: GO:0050657
name: nucleic acid transport
namespace: biological_process
def: "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport

[Term]
id: GO:0050658
name: RNA transport
namespace: biological_process
def: "The directed movement of RNA, ribonucleic acids, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050657 ! nucleic acid transport
is_a: GO:0051236 ! establishment of RNA localization

[Term]
id: GO:0050659
name: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.33]
synonym: "3'-phosphoadenylyl-sulfate:dermatan 6'-sulfotransferase activity" EXACT [EC:2.8.2.33]
synonym: "GalNAc4S-6ST" RELATED [EC:2.8.2.33]
synonym: "N-acetylgalactosamine 4-sulfate 6-O-sulphotransferase activity" EXACT [EC:2.8.2.33]
xref: EC:2.8.2.33
xref: MetaCyc:RXN-7953
xref: MetaCyc:RXN-7954
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050660
name: FAD binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "flavin adenine dinucleotide binding" EXACT []
synonym: "flavine-adenine dinucleotide binding" EXACT []
is_a: GO:0030554 ! adenyl nucleotide binding
is_a: GO:0050662 ! coenzyme binding

[Term]
id: GO:0050661
name: NADP or NADPH binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH." [GOC:ai]
synonym: "nicotinamide adenine dinucleotide phosphate binding" EXACT []
is_a: GO:0000166 ! nucleotide binding
is_a: GO:0050662 ! coenzyme binding

[Term]
id: GO:0050662
name: coenzyme binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0048037 ! cofactor binding

[Term]
id: GO:0050663
name: cytokine secretion
namespace: biological_process
def: "The regulated release of cytokines from a cell or group of cells. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471]
is_a: GO:0009306 ! protein secretion
relationship: part_of GO:0001816 ! cytokine production

[Term]
id: GO:0050664
name: oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor
namespace: molecular_function
def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule." [EC:1.6.3.-]
xref: EC:1.6.3
is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH

[Term]
id: GO:0050665
name: hydrogen peroxide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:ai]
subset: gosubset_prok
synonym: "H2O2 biosynthetic process" EXACT [GOc:mah]
synonym: "hydrogen peroxide anabolism" EXACT []
synonym: "hydrogen peroxide biosynthesis" EXACT []
synonym: "hydrogen peroxide formation" EXACT []
synonym: "hydrogen peroxide generation" EXACT []
synonym: "hydrogen peroxide synthesis" EXACT []
is_a: GO:0042743 ! hydrogen peroxide metabolic process
is_a: GO:0044249 ! cellular biosynthetic process

[Term]
id: GO:0050666
name: regulation of homocysteine metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of Hcy metabolic process" EXACT []
synonym: "regulation of Hcy metabolism" EXACT []
synonym: "regulation of homocysteine metabolism" EXACT []
is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process
relationship: regulates GO:0050667 ! homocysteine metabolic process

[Term]
id: GO:0050667
name: homocysteine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "Hcy metabolic process" EXACT []
synonym: "Hcy metabolism" EXACT []
synonym: "homocysteine metabolism" EXACT []
is_a: GO:0000096 ! sulfur amino acid metabolic process

[Term]
id: GO:0050668
name: positive regulation of homocysteine metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." [GOC:ai]
subset: gosubset_prok
synonym: "activation of homocysteine metabolic process" NARROW []
synonym: "positive regulation of Hcy metabolic process" EXACT []
synonym: "positive regulation of Hcy metabolism" EXACT []
synonym: "positive regulation of homocysteine metabolism" EXACT []
synonym: "stimulation of homocysteine metabolic process" NARROW []
synonym: "up regulation of homocysteine metabolic process" EXACT []
synonym: "up-regulation of homocysteine metabolic process" EXACT []
synonym: "upregulation of homocysteine metabolic process" EXACT []
is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process
is_a: GO:0050666 ! regulation of homocysteine metabolic process
relationship: positively_regulates GO:0050667 ! homocysteine metabolic process

[Term]
id: GO:0050669
name: negative regulation of homocysteine metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of homocysteine metabolic process" EXACT []
synonym: "down-regulation of homocysteine metabolic process" EXACT []
synonym: "downregulation of homocysteine metabolic process" EXACT []
synonym: "inhibition of homocysteine metabolic process" NARROW []
synonym: "negative regulation of Hcy metabolic process" EXACT []
synonym: "negative regulation of Hcy metabolism" EXACT []
synonym: "negative regulation of homocysteine metabolism" EXACT []
is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process
is_a: GO:0050666 ! regulation of homocysteine metabolic process
relationship: negatively_regulates GO:0050667 ! homocysteine metabolic process

[Term]
id: GO:0050670
name: regulation of lymphocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte proliferation." [GOC:ai]
is_a: GO:0032944 ! regulation of mononuclear cell proliferation
is_a: GO:0051249 ! regulation of lymphocyte activation
relationship: regulates GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0050671
name: positive regulation of lymphocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of lymphocyte proliferation." [GOC:ai]
synonym: "activation of lymphocyte proliferation" NARROW []
synonym: "stimulation of lymphocyte proliferation" NARROW []
synonym: "up regulation of lymphocyte proliferation" EXACT []
synonym: "up-regulation of lymphocyte proliferation" EXACT []
synonym: "upregulation of lymphocyte proliferation" EXACT []
is_a: GO:0032946 ! positive regulation of mononuclear cell proliferation
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
relationship: positively_regulates GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0050672
name: negative regulation of lymphocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation." [GOC:ai]
synonym: "down regulation of lymphocyte proliferation" EXACT []
synonym: "down-regulation of lymphocyte proliferation" EXACT []
synonym: "downregulation of lymphocyte proliferation" EXACT []
synonym: "inhibition of lymphocyte proliferation" NARROW []
is_a: GO:0032945 ! negative regulation of mononuclear cell proliferation
is_a: GO:0050670 ! regulation of lymphocyte proliferation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
relationship: negatively_regulates GO:0046651 ! lymphocyte proliferation

[Term]
id: GO:0050673
name: epithelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0050674
name: urothelial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of urothelial cells, resulting in the expansion of a cell population. Urothelial cells make up a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0050675
name: regulation of urothelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of urothelial cell proliferation." [GOC:ai]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: regulates GO:0050674 ! urothelial cell proliferation

[Term]
id: GO:0050676
name: negative regulation of urothelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of urothelial cell proliferation." [GOC:ai]
synonym: "down regulation of urothelial cell proliferation" EXACT []
synonym: "down-regulation of urothelial cell proliferation" EXACT []
synonym: "downregulation of urothelial cell proliferation" EXACT []
synonym: "inhibition of urothelial cell proliferation" NARROW []
is_a: GO:0050675 ! regulation of urothelial cell proliferation
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
relationship: negatively_regulates GO:0050674 ! urothelial cell proliferation

[Term]
id: GO:0050677
name: positive regulation of urothelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of urothelial cell proliferation." [GOC:ai]
synonym: "activation of urothelial cell proliferation" NARROW []
synonym: "stimulation of urothelial cell proliferation" NARROW []
synonym: "up regulation of urothelial cell proliferation" EXACT []
synonym: "up-regulation of urothelial cell proliferation" EXACT []
synonym: "upregulation of urothelial cell proliferation" EXACT []
is_a: GO:0050675 ! regulation of urothelial cell proliferation
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
relationship: positively_regulates GO:0050674 ! urothelial cell proliferation

[Term]
id: GO:0050678
name: regulation of epithelial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai]
is_a: GO:0042127 ! regulation of cell proliferation
relationship: regulates GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0050679
name: positive regulation of epithelial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai]
synonym: "activation of epithelial cell proliferation" NARROW []
synonym: "stimulation of epithelial cell proliferation" NARROW []
synonym: "up regulation of epithelial cell proliferation" EXACT []
synonym: "up-regulation of epithelial cell proliferation" EXACT []
synonym: "upregulation of epithelial cell proliferation" EXACT []
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: positively_regulates GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0050680
name: negative regulation of epithelial cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai]
synonym: "down regulation of epithelial cell proliferation" EXACT []
synonym: "down-regulation of epithelial cell proliferation" EXACT []
synonym: "downregulation of epithelial cell proliferation" EXACT []
synonym: "inhibition of epithelial cell proliferation" NARROW []
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0050678 ! regulation of epithelial cell proliferation
relationship: negatively_regulates GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0050681
name: androgen receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an androgen receptor." [GOC:ai]
synonym: "AR binding" EXACT []
is_a: GO:0035258 ! steroid hormone receptor binding

[Term]
id: GO:0050682
name: AF-2 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the AF-2 domain of a protein, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation." [PMID:9682036]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050683
name: AF-1 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the AF-1 domain of a protein, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor." [PMID:9682036]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050684
name: regulation of mRNA processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai]
subset: gosubset_prok
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: regulates GO:0006397 ! mRNA processing

[Term]
id: GO:0050685
name: positive regulation of mRNA processing
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of mRNA processing." [GOC:ai]
subset: gosubset_prok
synonym: "activation of mRNA processing" NARROW []
synonym: "stimulation of mRNA processing" NARROW []
synonym: "up regulation of mRNA processing" EXACT []
synonym: "up-regulation of mRNA processing" EXACT []
synonym: "upregulation of mRNA processing" EXACT []
is_a: GO:0050684 ! regulation of mRNA processing
is_a: GO:0051254 ! positive regulation of RNA metabolic process
relationship: positively_regulates GO:0006397 ! mRNA processing

[Term]
id: GO:0050686
name: negative regulation of mRNA processing
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA processing." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of mRNA processing" EXACT []
synonym: "down-regulation of mRNA processing" EXACT []
synonym: "downregulation of mRNA processing" EXACT []
synonym: "inhibition of mRNA processing" NARROW []
is_a: GO:0050684 ! regulation of mRNA processing
is_a: GO:0051253 ! negative regulation of RNA metabolic process
relationship: negatively_regulates GO:0006397 ! mRNA processing

[Term]
id: GO:0050687
name: negative regulation of defense response to virus
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication." [GOC:ai]
synonym: "down regulation of antiviral response" EXACT []
synonym: "down-regulation of antiviral response" EXACT []
synonym: "downregulation of antiviral response" EXACT []
synonym: "inhibition of antiviral response" NARROW []
synonym: "negative regulation of antiviral response" EXACT [GOC:dph]
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0002832 ! negative regulation of response to biotic stimulus
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0050688 ! regulation of defense response to virus
relationship: negatively_regulates GO:0051607 ! defense response to virus

[Term]
id: GO:0050688
name: regulation of defense response to virus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." [GOC:ai]
synonym: "regulation of antiviral response" EXACT []
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0043900 ! regulation of multi-organism process
relationship: regulates GO:0051607 ! defense response to virus

[Term]
id: GO:0050689
name: negative regulation of defense response to virus by host
namespace: biological_process
def: "Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ai, GOC:dph, GOC:tb]
synonym: "down regulation of antiviral response by host" EXACT []
synonym: "down-regulation of antiviral response by host" EXACT []
synonym: "downregulation of antiviral response by host" EXACT []
synonym: "inhibition of antiviral response by host" NARROW []
synonym: "negative regulation by host of antiviral response" EXACT []
synonym: "negative regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb]
is_a: GO:0050687 ! negative regulation of defense response to virus
is_a: GO:0050691 ! regulation of defense response to virus by host

[Term]
id: GO:0050690
name: regulation of defense response to virus by virus
namespace: biological_process
def: "Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism." [GOC:ai, GOC:dph]
synonym: "regulation by virus of antiviral response" EXACT []
synonym: "regulation of antiviral response by virus" EXACT [GOC:dph]
synonym: "viral regulation of antiviral response" EXACT []
xref: Reactome:164938 "Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters"
xref: Reactome:164939 "Nef mediated downregulation of CD28 cell surface expression"
xref: Reactome:164940 "Nef mediated downregulation of MHC class I complex cell surface expression"
xref: Reactome:164943 "Nef mediated activation of the T-cell receptor"
xref: Reactome:164944 "Nef and signal transduction"
xref: Reactome:167590 "Nef Mediated CD4 Down-regulation"
xref: Reactome:182218 "Nef Mediated CD8 Down-regulation"
is_a: GO:0050688 ! regulation of defense response to virus

[Term]
id: GO:0050691
name: regulation of defense response to virus by host
namespace: biological_process
def: "Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism." [GOC:ai, GOC:dph]
synonym: "host regulation of antiviral response" EXACT []
synonym: "regulation by host of antiviral response" EXACT []
synonym: "regulation of antiviral response by host" RELATED [GOC:dph]
is_a: GO:0050688 ! regulation of defense response to virus

[Term]
id: GO:0050692
name: DBD domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the DBD, DNA binding domain, of a protein. The DNA binding domain of the vitamin D receptor, one of a family of receptors with the DBD, is split into three regions, the P, D and T boxes. Residues that are critical for target sequence selectivity form the P-box. The D-box contains residues that are important for homodimerization of class I nuclear receptors. The T-box is essential for both DNA-binding and transactivation of the VDR; this region may also be important for dimerization with RXR for class II nuclear receptors." [PMID:9682036]
synonym: "DNA binding domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050693
name: LBD domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the LBD, the ligand binding domain found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket." [PMID:9682036]
synonym: "ligand binding domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050694
name: galactose 3-O-sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc." [GOC:ai, PMID:11323440, PMID:11356829]
synonym: "Gal-3-O-sulfotransferase activity" EXACT []
synonym: "galactose 3-O-sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050695
name: benzoylformate decarboxylase activity
namespace: molecular_function
def: "Catalysis of the reaction: benzoylformate = benzaldehyde + CO2." [EC:4.1.1.7, MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN]
subset: gosubset_prok
synonym: "benzoylformate carboxy-lyase (benzaldehyde-forming)" EXACT [EC:4.1.1.7]
synonym: "benzoylformate carboxy-lyase activity" EXACT [EC:4.1.1.7]
synonym: "phenylglyoxylate decarboxylase activity" EXACT []
xref: EC:4.1.1.7
xref: MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN
xref: UM-BBD_enzymeID:e0652
is_a: GO:0016831 ! carboxy-lyase activity

[Term]
id: GO:0050696
name: trichloroethylene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent." [GOC:ai]
subset: gosubset_prok
synonym: "trichloroethene catabolic process" EXACT []
synonym: "trichloroethene catabolism" EXACT []
synonym: "trichloroethylene breakdown" EXACT []
synonym: "trichloroethylene catabolism" EXACT []
synonym: "trichloroethylene degradation" EXACT []
is_a: GO:0018979 ! trichloroethylene metabolic process
is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process

[Term]
id: GO:0050697
name: 1,1,2-trichloroethene reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene." [MetaCyc:TCEREDCHLOR-RXN, UM-BBD_enzymeID:e0271]
synonym: "1,1,2-trichloroethylene reductive dehalogenase activity" EXACT []
synonym: "TCE-reductive dehalogenase activity" EXACT []
xref: MetaCyc:TCEREDCHLOR-RXN
xref: UM-BBD_enzymeID:e0271
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0050698
name: proteoglycan sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans." [EC:2.8.2.-, GOC:ai]
synonym: "proteoglycan sulfate transfer" RELATED []
synonym: "proteoglycan sulphotransferase activity" EXACT []
xref: EC:2.8.2.-
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0050699
name: WW domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions." [PMID:14531730]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050700
name: CARD domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family." [PMID:12054670]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050701
name: interleukin-1 secretion
namespace: biological_process
def: "The regulated release of interleukin-1 from a cell or group of cells. Interleukin 1 is produced mainly by activated macrophages; it stimulates thymocyte proliferation by inducing interleukin 2 release and it is involved in the inflammatory response." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "IL-1 secretion" EXACT []
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032612 ! interleukin-1 production

[Term]
id: GO:0050702
name: interleukin-1 beta secretion
namespace: biological_process
def: "The regulated release of interleukin 1 beta from a cell or group of cells." [GOC:ai]
synonym: "IL-1b secretion" EXACT []
is_a: GO:0050701 ! interleukin-1 secretion
relationship: part_of GO:0032611 ! interleukin-1 beta production

[Term]
id: GO:0050703
name: interleukin-1 alpha secretion
namespace: biological_process
def: "The regulated release of interleukin-1 alpha from a cell or group of cells." [GOC:ai]
synonym: "IL-1a secretion" EXACT []
is_a: GO:0050701 ! interleukin-1 secretion
relationship: part_of GO:0032610 ! interleukin-1 alpha production

[Term]
id: GO:0050704
name: regulation of interleukin-1 secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells." [GOC:ai]
is_a: GO:0032652 ! regulation of interleukin-1 production
is_a: GO:0050707 ! regulation of cytokine secretion
relationship: regulates GO:0050701 ! interleukin-1 secretion

[Term]
id: GO:0050705
name: regulation of interleukin-1 alpha secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell or group of cells." [GOC:ai]
is_a: GO:0032650 ! regulation of interleukin-1 alpha production
is_a: GO:0050704 ! regulation of interleukin-1 secretion
relationship: regulates GO:0050703 ! interleukin-1 alpha secretion

[Term]
id: GO:0050706
name: regulation of interleukin-1 beta secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell or group of cells." [GOC:ai]
is_a: GO:0032651 ! regulation of interleukin-1 beta production
is_a: GO:0050704 ! regulation of interleukin-1 secretion
relationship: regulates GO:0050702 ! interleukin-1 beta secretion

[Term]
id: GO:0050707
name: regulation of cytokine secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells." [GOC:ai]
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0050708 ! regulation of protein secretion
relationship: regulates GO:0050663 ! cytokine secretion

[Term]
id: GO:0050708
name: regulation of protein secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell or group of cells." [GOC:ai]
subset: gosubset_prok
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051223 ! regulation of protein transport
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0009306 ! protein secretion

[Term]
id: GO:0050709
name: negative regulation of protein secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of a protein from a cell or group of cells." [GOC:ai]
synonym: "down regulation of protein secretion" EXACT []
synonym: "down-regulation of protein secretion" EXACT []
synonym: "downregulation of protein secretion" EXACT []
synonym: "inhibition of protein secretion" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051224 ! negative regulation of protein transport
relationship: negatively_regulates GO:0009306 ! protein secretion

[Term]
id: GO:0050710
name: negative regulation of cytokine secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells." [GOC:ai]
synonym: "down regulation of cytokine secretion" EXACT []
synonym: "down-regulation of cytokine secretion" EXACT []
synonym: "downregulation of cytokine secretion" EXACT []
synonym: "inhibition of cytokine secretion" NARROW []
is_a: GO:0050707 ! regulation of cytokine secretion
is_a: GO:0050709 ! negative regulation of protein secretion
relationship: negatively_regulates GO:0050663 ! cytokine secretion

[Term]
id: GO:0050711
name: negative regulation of interleukin-1 secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells." [GOC:ai]
synonym: "down regulation of interleukin-1 secretion" EXACT []
synonym: "down-regulation of interleukin-1 secretion" EXACT []
synonym: "downregulation of interleukin-1 secretion" EXACT []
synonym: "inhibition of interleukin-1 secretion" NARROW []
is_a: GO:0032692 ! negative regulation of interleukin-1 production
is_a: GO:0050704 ! regulation of interleukin-1 secretion
is_a: GO:0050710 ! negative regulation of cytokine secretion
relationship: negatively_regulates GO:0050701 ! interleukin-1 secretion

[Term]
id: GO:0050712
name: negative regulation of interleukin-1 alpha secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell or group of cells." [GOC:ai]
synonym: "down regulation of interleukin-1 alpha secretion" EXACT []
synonym: "down-regulation of interleukin-1 alpha secretion" EXACT []
synonym: "downregulation of interleukin-1 alpha secretion" EXACT []
synonym: "inhibition of interleukin-1 alpha secretion" NARROW []
is_a: GO:0032690 ! negative regulation of interleukin-1 alpha production
is_a: GO:0050705 ! regulation of interleukin-1 alpha secretion
is_a: GO:0050711 ! negative regulation of interleukin-1 secretion
relationship: negatively_regulates GO:0050703 ! interleukin-1 alpha secretion

[Term]
id: GO:0050713
name: negative regulation of interleukin-1 beta secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell or group of cells." [GOC:ai]
synonym: "down regulation of interleukin-1 beta secretion" EXACT []
synonym: "down-regulation of interleukin-1 beta secretion" EXACT []
synonym: "downregulation of interleukin-1 beta secretion" EXACT []
synonym: "inhibition of interleukin-1 beta secretion" NARROW []
is_a: GO:0032691 ! negative regulation of interleukin-1 beta production
is_a: GO:0050706 ! regulation of interleukin-1 beta secretion
is_a: GO:0050711 ! negative regulation of interleukin-1 secretion
relationship: negatively_regulates GO:0050702 ! interleukin-1 beta secretion

[Term]
id: GO:0050714
name: positive regulation of protein secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell or group of cells." [GOC:ai]
synonym: "activation of protein secretion" NARROW []
synonym: "stimulation of protein secretion" NARROW []
synonym: "up regulation of protein secretion" EXACT []
synonym: "up-regulation of protein secretion" EXACT []
synonym: "upregulation of protein secretion" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0050708 ! regulation of protein secretion
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051222 ! positive regulation of protein transport
relationship: positively_regulates GO:0009306 ! protein secretion

[Term]
id: GO:0050715
name: positive regulation of cytokine secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell or group of cells." [GOC:ai]
synonym: "activation of cytokine secretion" NARROW []
synonym: "stimulation of cytokine secretion" NARROW []
synonym: "up regulation of cytokine secretion" EXACT []
synonym: "up-regulation of cytokine secretion" EXACT []
synonym: "upregulation of cytokine secretion" EXACT []
is_a: GO:0050707 ! regulation of cytokine secretion
is_a: GO:0050714 ! positive regulation of protein secretion
relationship: positively_regulates GO:0050663 ! cytokine secretion

[Term]
id: GO:0050716
name: positive regulation of interleukin-1 secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell or group of cells." [GOC:ai]
synonym: "activation of interleukin-1 secretion" NARROW []
synonym: "stimulation of interleukin-1 secretion" NARROW []
synonym: "up regulation of interleukin-1 secretion" EXACT []
synonym: "up-regulation of interleukin-1 secretion" EXACT []
synonym: "upregulation of interleukin-1 secretion" EXACT []
is_a: GO:0032732 ! positive regulation of interleukin-1 production
is_a: GO:0050704 ! regulation of interleukin-1 secretion
is_a: GO:0050715 ! positive regulation of cytokine secretion
relationship: positively_regulates GO:0050701 ! interleukin-1 secretion

[Term]
id: GO:0050717
name: positive regulation of interleukin-1 alpha secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell or group of cells." [GOC:ai]
synonym: "activation of interleukin-1 alpha secretion" NARROW []
synonym: "stimulation of interleukin-1 alpha secretion" NARROW []
synonym: "up regulation of interleukin-1 alpha secretion" EXACT []
synonym: "up-regulation of interleukin-1 alpha secretion" EXACT []
synonym: "upregulation of interleukin-1 alpha secretion" EXACT []
is_a: GO:0032730 ! positive regulation of interleukin-1 alpha production
is_a: GO:0050705 ! regulation of interleukin-1 alpha secretion
is_a: GO:0050716 ! positive regulation of interleukin-1 secretion
relationship: positively_regulates GO:0050703 ! interleukin-1 alpha secretion

[Term]
id: GO:0050718
name: positive regulation of interleukin-1 beta secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell or group of cells." [GOC:ai]
synonym: "activation of interleukin-1 beta secretion" NARROW []
synonym: "stimulation of interleukin-1 beta secretion" NARROW []
synonym: "up regulation of interleukin-1 beta secretion" EXACT []
synonym: "up-regulation of interleukin-1 beta secretion" EXACT []
synonym: "upregulation of interleukin-1 beta secretion" EXACT []
is_a: GO:0032731 ! positive regulation of interleukin-1 beta production
is_a: GO:0050706 ! regulation of interleukin-1 beta secretion
is_a: GO:0050716 ! positive regulation of interleukin-1 secretion
relationship: positively_regulates GO:0050702 ! interleukin-1 beta secretion

[Term]
id: GO:0050719
name: interleukin-1 alpha biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai]
synonym: "interleukin-1 alpha anabolism" EXACT []
synonym: "interleukin-1 alpha biosynthesis" EXACT []
synonym: "interleukin-1 alpha formation" EXACT []
synonym: "interleukin-1 alpha synthesis" EXACT []
is_a: GO:0042222 ! interleukin-1 biosynthetic process
relationship: part_of GO:0032610 ! interleukin-1 alpha production

[Term]
id: GO:0050720
name: interleukin-1 beta biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai]
synonym: "interleukin-1 beta anabolism" EXACT []
synonym: "interleukin-1 beta biosynthesis" EXACT []
synonym: "interleukin-1 beta formation" EXACT []
synonym: "interleukin-1 beta synthesis" EXACT []
is_a: GO:0042222 ! interleukin-1 biosynthetic process
relationship: part_of GO:0032611 ! interleukin-1 beta production

[Term]
id: GO:0050721
name: regulation of interleukin-1 alpha biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai]
synonym: "regulation of interleukin-1 alpha anabolism" EXACT []
synonym: "regulation of interleukin-1 alpha biosynthesis" EXACT []
synonym: "regulation of interleukin-1 alpha formation" EXACT []
synonym: "regulation of interleukin-1 alpha synthesis" EXACT []
is_a: GO:0032650 ! regulation of interleukin-1 alpha production
is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process
relationship: regulates GO:0050719 ! interleukin-1 alpha biosynthetic process

[Term]
id: GO:0050722
name: regulation of interleukin-1 beta biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai]
synonym: "regulation of interleukin-1 beta anabolism" EXACT []
synonym: "regulation of interleukin-1 beta biosynthesis" EXACT []
synonym: "regulation of interleukin-1 beta formation" EXACT []
synonym: "regulation of interleukin-1 beta synthesis" EXACT []
is_a: GO:0032651 ! regulation of interleukin-1 beta production
is_a: GO:0045360 ! regulation of interleukin-1 biosynthetic process
relationship: regulates GO:0050720 ! interleukin-1 beta biosynthetic process

[Term]
id: GO:0050723
name: negative regulation of interleukin-1 alpha biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai]
synonym: "down regulation of interleukin-1 alpha biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-1 alpha biosynthetic process" EXACT []
synonym: "downregulation of interleukin-1 alpha biosynthetic process" EXACT []
synonym: "inhibition of interleukin-1 alpha biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-1 alpha anabolism" EXACT []
synonym: "negative regulation of interleukin-1 alpha biosynthesis" EXACT []
synonym: "negative regulation of interleukin-1 alpha formation" EXACT []
synonym: "negative regulation of interleukin-1 alpha synthesis" EXACT []
is_a: GO:0045361 ! negative regulation of interleukin-1 biosynthetic process
is_a: GO:0050721 ! regulation of interleukin-1 alpha biosynthetic process
relationship: negatively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process

[Term]
id: GO:0050724
name: negative regulation of interleukin-1 beta biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai]
synonym: "down regulation of interleukin-1 beta biosynthetic process" EXACT []
synonym: "down-regulation of interleukin-1 beta biosynthetic process" EXACT []
synonym: "downregulation of interleukin-1 beta biosynthetic process" EXACT []
synonym: "inhibition of interleukin-1 beta biosynthetic process" NARROW []
synonym: "negative regulation of interleukin-1 beta anabolism" EXACT []
synonym: "negative regulation of interleukin-1 beta biosynthesis" EXACT []
synonym: "negative regulation of interleukin-1 beta formation" EXACT []
synonym: "negative regulation of interleukin-1 beta synthesis" EXACT []
is_a: GO:0045361 ! negative regulation of interleukin-1 biosynthetic process
is_a: GO:0050722 ! regulation of interleukin-1 beta biosynthetic process
relationship: negatively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process

[Term]
id: GO:0050725
name: positive regulation of interleukin-1 beta biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai]
synonym: "activation of interleukin-1 beta biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-1 beta anabolism" EXACT []
synonym: "positive regulation of interleukin-1 beta biosynthesis" EXACT []
synonym: "positive regulation of interleukin-1 beta formation" EXACT []
synonym: "positive regulation of interleukin-1 beta synthesis" EXACT []
synonym: "stimulation of interleukin-1 beta biosynthetic process" NARROW []
synonym: "up regulation of interleukin-1 beta biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-1 beta biosynthetic process" EXACT []
synonym: "upregulation of interleukin-1 beta biosynthetic process" EXACT []
is_a: GO:0045362 ! positive regulation of interleukin-1 biosynthetic process
is_a: GO:0050722 ! regulation of interleukin-1 beta biosynthetic process
relationship: positively_regulates GO:0050720 ! interleukin-1 beta biosynthetic process

[Term]
id: GO:0050726
name: positive regulation of interleukin-1 alpha biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai]
synonym: "activation of interleukin-1 alpha biosynthetic process" NARROW []
synonym: "positive regulation of interleukin-1 alpha anabolism" EXACT []
synonym: "positive regulation of interleukin-1 alpha biosynthesis" EXACT []
synonym: "positive regulation of interleukin-1 alpha formation" EXACT []
synonym: "positive regulation of interleukin-1 alpha synthesis" EXACT []
synonym: "stimulation of interleukin-1 alpha biosynthetic process" NARROW []
synonym: "up regulation of interleukin-1 alpha biosynthetic process" EXACT []
synonym: "up-regulation of interleukin-1 alpha biosynthetic process" EXACT []
synonym: "upregulation of interleukin-1 alpha biosynthetic process" EXACT []
is_a: GO:0045362 ! positive regulation of interleukin-1 biosynthetic process
is_a: GO:0050721 ! regulation of interleukin-1 alpha biosynthetic process
relationship: positively_regulates GO:0050719 ! interleukin-1 alpha biosynthetic process

[Term]
id: GO:0050727
name: regulation of inflammatory response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai]
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0032101 ! regulation of response to external stimulus
relationship: regulates GO:0006954 ! inflammatory response

[Term]
id: GO:0050728
name: negative regulation of inflammatory response
namespace: biological_process
alt_id: GO:0030236
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai]
synonym: "anti-inflammatory response" EXACT []
synonym: "down regulation of inflammatory response" EXACT []
synonym: "down-regulation of inflammatory response" EXACT []
synonym: "downregulation of inflammatory response" EXACT []
synonym: "inhibition of inflammatory response" NARROW []
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0050727 ! regulation of inflammatory response
relationship: negatively_regulates GO:0006954 ! inflammatory response

[Term]
id: GO:0050729
name: positive regulation of inflammatory response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response." [GOC:ai]
synonym: "activation of inflammatory response" NARROW []
synonym: "stimulation of inflammatory response" NARROW []
synonym: "up regulation of inflammatory response" EXACT []
synonym: "up-regulation of inflammatory response" EXACT []
synonym: "upregulation of inflammatory response" EXACT []
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0050727 ! regulation of inflammatory response
relationship: positively_regulates GO:0006954 ! inflammatory response

[Term]
id: GO:0050730
name: regulation of peptidyl-tyrosine phosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai]
subset: gosubset_prok
is_a: GO:0001932 ! regulation of protein amino acid phosphorylation
relationship: regulates GO:0018108 ! peptidyl-tyrosine phosphorylation

[Term]
id: GO:0050731
name: positive regulation of peptidyl-tyrosine phosphorylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai]
subset: gosubset_prok
synonym: "activation of peptidyl-tyrosine phosphorylation" NARROW []
synonym: "stimulation of peptidyl-tyrosine phosphorylation" NARROW []
synonym: "up regulation of peptidyl-tyrosine phosphorylation" EXACT []
synonym: "up-regulation of peptidyl-tyrosine phosphorylation" EXACT []
synonym: "upregulation of peptidyl-tyrosine phosphorylation" EXACT []
is_a: GO:0001934 ! positive regulation of protein amino acid phosphorylation
is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation
relationship: positively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation

[Term]
id: GO:0050732
name: negative regulation of peptidyl-tyrosine phosphorylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of peptidyl-tyrosine phosphorylation" EXACT []
synonym: "down-regulation of peptidyl-tyrosine phosphorylation" EXACT []
synonym: "downregulation of peptidyl-tyrosine phosphorylation" EXACT []
synonym: "inhibition of peptidyl-tyrosine phosphorylation" NARROW []
is_a: GO:0001933 ! negative regulation of protein amino acid phosphorylation
is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation
relationship: negatively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation

[Term]
id: GO:0050733
name: RS domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing." [PMID:11684676, PMID:12215544]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0050734
name: hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hydroxycinnamoyl group to an acceptor molecule." [GOC:ai]
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0050735
name: N-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]
is_a: GO:0016410 ! N-acyltransferase activity
is_a: GO:0016420 ! malonyltransferase activity

[Term]
id: GO:0050736
name: O-malonyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a malonyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0016420 ! malonyltransferase activity

[Term]
id: GO:0050737
name: O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule." [GOC:ai]
is_a: GO:0008374 ! O-acyltransferase activity
is_a: GO:0050734 ! hydroxycinnamoyltransferase activity

[Term]
id: GO:0050738
name: fructosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0050739
name: peptide cross-linking via S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium
namespace: biological_process
def: "The posttranslational cross-linking of a tyrosine residue to a tryptophan residue and a methionine residue to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium." [RESID:AA0348]
subset: gosubset_prok
xref: RESID:AA0348
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018206 ! peptidyl-methionine modification
is_a: GO:0018211 ! peptidyl-tryptophan modification
is_a: GO:0018212 ! peptidyl-tyrosine modification

[Term]
id: GO:0050740
name: protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine
namespace: biological_process
def: "The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine." [RESID:AA0349]
subset: gosubset_prok
xref: RESID:AA0349
is_a: GO:0018309 ! protein-FMN linkage

[Term]
id: GO:0050741
name: protein-FMN linkage via O3-riboflavin phosphoryl-L-serine
namespace: biological_process
def: "The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-serine." [RESID:AA0350]
subset: gosubset_prok
xref: RESID:AA0350
is_a: GO:0018309 ! protein-FMN linkage

[Term]
id: GO:0050742
name: protein-FMN linkage via S-(4a-FMN)-L-cysteine
namespace: biological_process
def: "The formation of a protein-FMN linkage via S-(4a-FMN)-L-cysteine." [RESID:AA0351]
subset: gosubset_prok
xref: RESID:AA0351
is_a: GO:0018309 ! protein-FMN linkage

[Term]
id: GO:0050743
name: protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine
namespace: biological_process
def: "The formation of a protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine." [PMID:8611516, RESID:AA0352]
subset: gosubset_prok
xref: RESID:AA0352
is_a: GO:0018309 ! protein-FMN linkage

[Term]
id: GO:0050744
name: protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine
namespace: biological_process
def: "The formation of a protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine." [RESID:AA0353]
subset: gosubset_prok
xref: RESID:AA0353
is_a: GO:0018309 ! protein-FMN linkage

[Term]
id: GO:0050745
name: peptide cross-linking via L-cysteinyl-5-imidazolinone glycine
namespace: biological_process
def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, a cysteine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0188]
subset: gosubset_prok
xref: RESID:AA0188
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine

[Term]
id: GO:0050746
name: regulation of lipoprotein metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of lipoprotein metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0050747
name: positive regulation of lipoprotein metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [GOC:ai]
subset: gosubset_prok
synonym: "activation of lipoprotein metabolic process" NARROW []
synonym: "positive regulation of lipoprotein metabolism" EXACT []
synonym: "stimulation of lipoprotein metabolic process" NARROW []
synonym: "up regulation of lipoprotein metabolic process" EXACT []
synonym: "up-regulation of lipoprotein metabolic process" EXACT []
synonym: "upregulation of lipoprotein metabolic process" EXACT []
is_a: GO:0032270 ! positive regulation of cellular protein metabolic process
is_a: GO:0050746 ! regulation of lipoprotein metabolic process
relationship: positively_regulates GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0050748
name: negative regulation of lipoprotein metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of lipoprotein metabolic process" EXACT []
synonym: "down-regulation of lipoprotein metabolic process" EXACT []
synonym: "downregulation of lipoprotein metabolic process" EXACT []
synonym: "inhibition of lipoprotein metabolic process" NARROW []
synonym: "negative regulation of lipoprotein metabolism" EXACT []
is_a: GO:0032269 ! negative regulation of cellular protein metabolic process
is_a: GO:0050746 ! regulation of lipoprotein metabolic process
relationship: negatively_regulates GO:0042157 ! lipoprotein metabolic process

[Term]
id: GO:0050749
name: apolipoprotein E receptor binding
namespace: molecular_function
def: "OBSOLETE. Interacting selectively with an apolipoprotein E receptor." [GOC:ai]
comment: This term was made obsolete because no known receptor binds apolipoprotein E; instead, receptors bind holo-lipoprotein E (apolipoprotein E + bound lipid).
is_obsolete: true
replaced_by: GO:0070326

[Term]
id: GO:0050750
name: low-density lipoprotein receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a low-density lipoprotein receptor." [GOC:ai]
synonym: "LDL receptor binding" EXACT []
is_a: GO:0070325 ! lipoprotein receptor binding

[Term]
id: GO:0050751
name: fractalkine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1." [http://www.copewithcytokines.de]
synonym: "ABCD-3 biosynthesis" EXACT []
synonym: "ABCD-3 biosynthetic process" EXACT []
synonym: "CX3C membrane-anchored chemokine biosynthesis" EXACT []
synonym: "CX3C membrane-anchored chemokine biosynthetic process" EXACT []
synonym: "CX3CL1 biosynthesis" EXACT []
synonym: "CX3CL1 biosynthetic process" EXACT []
synonym: "fractalkine anabolism" EXACT []
synonym: "fractalkine biosynthesis" EXACT []
synonym: "fractalkine formation" EXACT []
synonym: "fractalkine synthesis" EXACT []
synonym: "neurotactin biosynthesis" EXACT []
synonym: "neurotactin biosynthetic process" EXACT []
is_a: GO:0042033 ! chemokine biosynthetic process
is_a: GO:0050756 ! fractalkine metabolic process
relationship: part_of GO:0032603 ! fractalkine production

[Term]
id: GO:0050752
name: regulation of fractalkine biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de]
synonym: "regulation of CX3CL1 biosynthesis" EXACT []
synonym: "regulation of CX3CL1 biosynthetic process" EXACT []
synonym: "regulation of fractalkine anabolism" EXACT []
synonym: "regulation of fractalkine biosynthesis" EXACT []
synonym: "regulation of fractalkine formation" EXACT []
synonym: "regulation of fractalkine synthesis" EXACT []
synonym: "regulation of neurotactin biosynthesis" EXACT []
synonym: "regulation of neurotactin biosynthetic process" EXACT []
is_a: GO:0032644 ! regulation of fractalkine production
is_a: GO:0045073 ! regulation of chemokine biosynthetic process
relationship: regulates GO:0050751 ! fractalkine biosynthetic process

[Term]
id: GO:0050753
name: negative regulation of fractalkine biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de]
synonym: "down regulation of fractalkine biosynthetic process" EXACT []
synonym: "down-regulation of fractalkine biosynthetic process" EXACT []
synonym: "downregulation of fractalkine biosynthetic process" EXACT []
synonym: "inhibition of fractalkine biosynthetic process" NARROW []
synonym: "negative regulation of CX3CL1 biosynthesis" EXACT []
synonym: "negative regulation of CX3CL1 biosynthetic process" EXACT []
synonym: "negative regulation of fractalkine anabolism" EXACT []
synonym: "negative regulation of fractalkine biosynthesis" EXACT []
synonym: "negative regulation of fractalkine formation" EXACT []
synonym: "negative regulation of fractalkine synthesis" EXACT []
synonym: "negative regulation of neurotactin biosynthesis" EXACT []
synonym: "negative regulation of neurotactin biosynthetic process" EXACT []
is_a: GO:0045079 ! negative regulation of chemokine biosynthetic process
is_a: GO:0050752 ! regulation of fractalkine biosynthetic process
relationship: negatively_regulates GO:0050751 ! fractalkine biosynthetic process

[Term]
id: GO:0050754
name: positive regulation of fractalkine biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de]
synonym: "activation of fractalkine biosynthetic process" NARROW []
synonym: "positive regulation of CX3CL1 biosynthesis" EXACT []
synonym: "positive regulation of CX3CL1 biosynthetic process" EXACT []
synonym: "positive regulation of fractalkine anabolism" EXACT []
synonym: "positive regulation of fractalkine biosynthesis" EXACT []
synonym: "positive regulation of fractalkine formation" EXACT []
synonym: "positive regulation of fractalkine synthesis" EXACT []
synonym: "positive regulation of neurotactin biosynthesis" EXACT []
synonym: "positive regulation of neurotactin biosynthetic process" EXACT []
synonym: "stimulation of fractalkine biosynthetic process" NARROW []
synonym: "up regulation of fractalkine biosynthetic process" EXACT []
synonym: "up-regulation of fractalkine biosynthetic process" EXACT []
synonym: "upregulation of fractalkine biosynthetic process" EXACT []
is_a: GO:0045080 ! positive regulation of chemokine biosynthetic process
is_a: GO:0050752 ! regulation of fractalkine biosynthetic process
relationship: positively_regulates GO:0050751 ! fractalkine biosynthetic process

[Term]
id: GO:0050755
name: chemokine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "chemokine metabolism" EXACT []
is_a: GO:0042107 ! cytokine metabolic process

[Term]
id: GO:0050756
name: fractalkine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1." [http://www.copewithcytokines.de]
synonym: "ABCD-3 metabolic process" EXACT []
synonym: "ABCD-3 metabolism" EXACT []
synonym: "CX3C membrane-anchored chemokine metabolic process" EXACT []
synonym: "CX3C membrane-anchored chemokine metabolism" EXACT []
synonym: "CX3CL1 metabolic process" EXACT []
synonym: "CX3CL1 metabolism" EXACT []
synonym: "fractalkine metabolism" EXACT []
synonym: "neurotactin metabolic process" EXACT []
synonym: "neurotactin metabolism" EXACT []
is_a: GO:0050755 ! chemokine metabolic process

[Term]
id: GO:0050757
name: thymidylate synthase biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP." [EC:2.1.1.45]
subset: gosubset_prok
synonym: "thymidylate synthase anabolism" EXACT []
synonym: "thymidylate synthase biosynthesis" EXACT []
synonym: "thymidylate synthase formation" EXACT []
synonym: "thymidylate synthase synthesis" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0050758
name: regulation of thymidylate synthase biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of thymidylate synthase anabolism" EXACT []
synonym: "regulation of thymidylate synthase biosynthesis" EXACT []
synonym: "regulation of thymidylate synthase formation" EXACT []
synonym: "regulation of thymidylate synthase synthesis" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
relationship: regulates GO:0050757 ! thymidylate synthase biosynthetic process

[Term]
id: GO:0050759
name: positive regulation of thymidylate synthase biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai]
subset: gosubset_prok
synonym: "activation of thymidylate synthase biosynthetic process" NARROW []
synonym: "positive regulation of thymidylate synthase anabolism" EXACT []
synonym: "positive regulation of thymidylate synthase biosynthesis" EXACT []
synonym: "positive regulation of thymidylate synthase formation" EXACT []
synonym: "positive regulation of thymidylate synthase synthesis" EXACT []
synonym: "stimulation of thymidylate synthase biosynthetic process" NARROW []
synonym: "up regulation of thymidylate synthase biosynthetic process" EXACT []
synonym: "up-regulation of thymidylate synthase biosynthetic process" EXACT []
synonym: "upregulation of thymidylate synthase biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0050758 ! regulation of thymidylate synthase biosynthetic process
relationship: positively_regulates GO:0050757 ! thymidylate synthase biosynthetic process

[Term]
id: GO:0050760
name: negative regulation of thymidylate synthase biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of thymidylate synthase biosynthetic process" EXACT []
synonym: "down-regulation of thymidylate synthase biosynthetic process" EXACT []
synonym: "downregulation of thymidylate synthase biosynthetic process" EXACT []
synonym: "inhibition of thymidylate synthase biosynthetic process" NARROW []
synonym: "negative regulation of thymidylate synthase anabolism" EXACT []
synonym: "negative regulation of thymidylate synthase biosynthesis" EXACT []
synonym: "negative regulation of thymidylate synthase formation" EXACT []
synonym: "negative regulation of thymidylate synthase synthesis" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0050758 ! regulation of thymidylate synthase biosynthetic process
relationship: negatively_regulates GO:0050757 ! thymidylate synthase biosynthetic process

[Term]
id: GO:0050761
name: depsipeptide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
synonym: "depsipeptide metabolism" EXACT []
is_a: GO:0006518 ! peptide metabolic process

[Term]
id: GO:0050762
name: depsipeptide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators]
subset: gosubset_prok
synonym: "depsipeptide breakdown" EXACT []
synonym: "depsipeptide catabolism" EXACT []
synonym: "depsipeptide degradation" EXACT []
is_a: GO:0043171 ! peptide catabolic process
is_a: GO:0050761 ! depsipeptide metabolic process

[Term]
id: GO:0050763
name: depsipeptide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators]
subset: gosubset_prok
synonym: "depsipeptide anabolism" EXACT []
synonym: "depsipeptide biosynthesis" EXACT []
synonym: "depsipeptide formation" EXACT []
synonym: "depsipeptide synthesis" EXACT []
is_a: GO:0043043 ! peptide biosynthetic process
is_a: GO:0050761 ! depsipeptide metabolic process

[Term]
id: GO:0050764
name: regulation of phagocytosis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phagocytosis, the process whereby phagocytes engulf external particulate material." [GOC:ai]
is_a: GO:0030100 ! regulation of endocytosis
relationship: regulates GO:0006909 ! phagocytosis

[Term]
id: GO:0050765
name: negative regulation of phagocytosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phagocytosis." [GOC:ai]
synonym: "down regulation of phagocytosis" EXACT []
synonym: "down-regulation of phagocytosis" EXACT []
synonym: "downregulation of phagocytosis" EXACT []
synonym: "inhibition of phagocytosis" NARROW []
is_a: GO:0045806 ! negative regulation of endocytosis
is_a: GO:0050764 ! regulation of phagocytosis
relationship: negatively_regulates GO:0006909 ! phagocytosis

[Term]
id: GO:0050766
name: positive regulation of phagocytosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phagocytosis." [GOC:ai]
synonym: "activation of phagocytosis" NARROW []
synonym: "stimulation of phagocytosis" NARROW []
synonym: "up regulation of phagocytosis" EXACT []
synonym: "up-regulation of phagocytosis" EXACT []
synonym: "upregulation of phagocytosis" EXACT []
is_a: GO:0045807 ! positive regulation of endocytosis
is_a: GO:0050764 ! regulation of phagocytosis
relationship: positively_regulates GO:0006909 ! phagocytosis

[Term]
id: GO:0050767
name: regulation of neurogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai]
is_a: GO:0051960 ! regulation of nervous system development
is_a: GO:0060284 ! regulation of cell development
relationship: part_of GO:0048699 ! generation of neurons
relationship: regulates GO:0022008 ! neurogenesis

[Term]
id: GO:0050768
name: negative regulation of neurogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai]
synonym: "down regulation of neurogenesis" EXACT []
synonym: "down-regulation of neurogenesis" EXACT []
synonym: "downregulation of neurogenesis" EXACT []
synonym: "inhibition of neurogenesis" NARROW []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0050767 ! regulation of neurogenesis
relationship: negatively_regulates GO:0022008 ! neurogenesis

[Term]
id: GO:0050769
name: positive regulation of neurogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai]
synonym: "activation of neurogenesis" NARROW []
synonym: "stimulation of neurogenesis" NARROW []
synonym: "up regulation of neurogenesis" EXACT []
synonym: "up-regulation of neurogenesis" EXACT []
synonym: "upregulation of neurogenesis" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0050767 ! regulation of neurogenesis
relationship: positively_regulates GO:0022008 ! neurogenesis

[Term]
id: GO:0050770
name: regulation of axonogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai]
xref: Reactome:193697 "p75NTR regulates axonogenesis"
xref: Reactome:449197 "p75NTR regulates axonogenesis"
xref: Reactome:470318 "p75NTR regulates axonogenesis"
xref: Reactome:487995 "p75NTR regulates axonogenesis"
xref: Reactome:507970 "p75NTR regulates axonogenesis"
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:0010975 ! regulation of neuron projection development
relationship: regulates GO:0007409 ! axonogenesis

[Term]
id: GO:0050771
name: negative regulation of axonogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of axonogenesis." [GOC:ai]
synonym: "down regulation of axonogenesis" EXACT []
synonym: "down-regulation of axonogenesis" EXACT []
synonym: "downregulation of axonogenesis" EXACT []
synonym: "inhibition of axonogenesis" NARROW []
xref: Reactome:193634 "Axonal growth inhibition (RHOA activation)"
xref: Reactome:449196 "Axonal growth inhibition (RHOA activation)"
xref: Reactome:470317 "Axonal growth inhibition (RHOA activation)"
xref: Reactome:487994 "Axonal growth inhibition (RHOA activation)"
xref: Reactome:508042 "Axonal growth inhibition (RHOA activation)"
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0050768 ! negative regulation of neurogenesis
is_a: GO:0050770 ! regulation of axonogenesis
relationship: negatively_regulates GO:0007409 ! axonogenesis

[Term]
id: GO:0050772
name: positive regulation of axonogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of axonogenesis." [GOC:ai]
synonym: "activation of axonogenesis" NARROW []
synonym: "stimulation of axonogenesis" NARROW []
synonym: "up regulation of axonogenesis" EXACT []
synonym: "up-regulation of axonogenesis" EXACT []
synonym: "upregulation of axonogenesis" EXACT []
xref: Reactome:209563 "Axonal growth stimulation"
xref: Reactome:449208 "Axonal growth stimulation"
xref: Reactome:470329 "Axonal growth stimulation"
xref: Reactome:488006 "Axonal growth stimulation"
xref: Reactome:507969 "Axonal growth stimulation"
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0050769 ! positive regulation of neurogenesis
is_a: GO:0050770 ! regulation of axonogenesis
relationship: positively_regulates GO:0007409 ! axonogenesis

[Term]
id: GO:0050773
name: regulation of dendrite development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai]
is_a: GO:0010975 ! regulation of neuron projection development
relationship: regulates GO:0016358 ! dendrite development

[Term]
id: GO:0050774
name: negative regulation of dendrite morphogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
synonym: "down regulation of dendrite morphogenesis" EXACT []
synonym: "down-regulation of dendrite morphogenesis" EXACT []
synonym: "downregulation of dendrite morphogenesis" EXACT []
synonym: "inhibition of dendrite morphogenesis" NARROW []
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0048814 ! regulation of dendrite morphogenesis
is_a: GO:0050768 ! negative regulation of neurogenesis
relationship: negatively_regulates GO:0048813 ! dendrite morphogenesis

[Term]
id: GO:0050775
name: positive regulation of dendrite morphogenesis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]
synonym: "activation of dendrite morphogenesis" NARROW []
synonym: "stimulation of dendrite morphogenesis" NARROW []
synonym: "up regulation of dendrite morphogenesis" EXACT []
synonym: "up-regulation of dendrite morphogenesis" EXACT []
synonym: "upregulation of dendrite morphogenesis" EXACT []
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0048814 ! regulation of dendrite morphogenesis
is_a: GO:0050769 ! positive regulation of neurogenesis
relationship: positively_regulates GO:0048813 ! dendrite morphogenesis

[Term]
id: GO:0050776
name: regulation of immune response
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
xref: Reactome:198933 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
xref: Reactome:448956 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
xref: Reactome:470075 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
xref: Reactome:487769 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
xref: Reactome:508076 "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0006955 ! immune response

[Term]
id: GO:0050777
name: negative regulation of immune response
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
synonym: "down regulation of immune response" EXACT []
synonym: "down-regulation of immune response" EXACT []
synonym: "downregulation of immune response" EXACT []
synonym: "inhibition of immune response" NARROW []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0050776 ! regulation of immune response
relationship: negatively_regulates GO:0006955 ! immune response

[Term]
id: GO:0050778
name: positive regulation of immune response
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]
synonym: "stimulation of immune response" NARROW []
synonym: "up regulation of immune response" EXACT []
synonym: "up-regulation of immune response" EXACT []
synonym: "upregulation of immune response" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0050776 ! regulation of immune response
relationship: positively_regulates GO:0006955 ! immune response

[Term]
id: GO:0050779
name: RNA destabilization
namespace: biological_process
def: "Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes." [GOC:ai]
subset: gosubset_prok
is_a: GO:0043487 ! regulation of RNA stability

[Term]
id: GO:0050780
name: dopamine receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a dopamine receptor." [GOC:ai]
is_a: GO:0001664 ! G-protein-coupled receptor binding

[Term]
id: GO:0050781
name: ortho-trichlorophenol reductive dehalogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2,4,6-trichlorophenol +2 H+ + 2 e- = 2,4-dichlorophenol + HCl." [GOC:ai, PMID:12697029]
subset: gosubset_prok
synonym: "2,4,6-TCP reductive dehalogenase activity" EXACT []
synonym: "2,4,6-trichlorophenol reductive dehalogenase activity" EXACT []
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0050782
name: galactose uniporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in)." [GOC:ai, TC:2.A.1.1.6]
synonym: "galactose, glucose uniporter activity" BROAD []
is_a: GO:0005354 ! galactose transmembrane transporter activity
is_a: GO:0008516 ! hexose uniporter activity

[Term]
id: GO:0050783
name: cocaine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cocaine metabolism" EXACT []
is_a: GO:0017144 ! drug metabolic process
is_a: GO:0046448 ! tropane alkaloid metabolic process

[Term]
id: GO:0050784
name: cocaine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "cocaine breakdown" EXACT []
synonym: "cocaine catabolism" EXACT []
synonym: "cocaine degradation" EXACT []
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0042737 ! drug catabolic process
is_a: GO:0046700 ! heterocycle catabolic process
is_a: GO:0050783 ! cocaine metabolic process

[Term]
id: GO:0050785
name: advanced glycation end-product receptor activity
namespace: molecular_function
def: "Combining with advanced glycation end-products to initiate a change in cell activity." [PMID:12453678, PMID:12707408, PMID:7592757, PMID:9224812]
synonym: "RAGE receptor activity" EXACT []
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0050786
name: RAGE receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products." [GOC:ai]
synonym: "advanced glycation end-product receptor binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0050787
name: detoxification of mercury ion
namespace: biological_process
def: "Any process that reduce or remove the toxicity of mercuric ion. These include transport of mercury away from sensitive areas and to compartments or complexes whose purpose is sequestration of mercury ion and/or reduction of mercury ion (Hg[II]) to metallic mercury (Hg[0])." [PMID:10774920]
subset: gosubset_prok
is_a: GO:0009636 ! response to toxin
is_a: GO:0046689 ! response to mercury ion

[Term]
id: GO:0050788
name: sequestering of mercury
namespace: biological_process
def: "The process of binding or confining toxic mercury ions or atoms such that they are separated from sensitive components of a biological system." [PMID:10774920]
synonym: "mercuric ion (Hg2+) sequestering" EXACT []
synonym: "mercuric ion (Hg2+) sequestration" EXACT []
synonym: "mercury (Hg) ion sequestering" EXACT []
synonym: "mercury (Hg) ion sequestration" EXACT []
synonym: "mercury (Hg2+) ion retention" EXACT []
synonym: "mercury (Hg2+) ion storage" EXACT []
synonym: "retention of mercury (Hg2+) ion" EXACT []
synonym: "sequestering of mercuric ion (Hg2+)" EXACT []
synonym: "sequestering of mercury (Hg) ion" EXACT []
synonym: "sequestration of mercuric ion (Hg2+)" EXACT []
synonym: "sequestration of mercury (Hg) ion" EXACT []
synonym: "storage of mercury (Hg2+) ion" EXACT []
is_a: GO:0051238 ! sequestering of metal ion
relationship: part_of GO:0050787 ! detoxification of mercury ion

[Term]
id: GO:0050789
name: regulation of biological process
namespace: biological_process
alt_id: GO:0050791
def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]
subset: goslim_generic
subset: goslim_goa
subset: gosubset_prok
synonym: "regulation of physiological process" EXACT []
is_a: GO:0065007 ! biological regulation
relationship: regulates GO:0008150 ! biological_process

[Term]
id: GO:0050790
name: regulation of catalytic activity
namespace: biological_process
def: "Any process that modulates the activity of an enzyme." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of enzyme activity" EXACT []
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0050792
name: regulation of viral reproduction
namespace: biological_process
def: "Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:go_curators, GOC:tb]
synonym: "regulation of viral life cycle" EXACT [GOC:tb]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0016032 ! viral reproduction

[Term]
id: GO:0050793
name: regulation of developmental process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0032502 ! developmental process

[Term]
id: GO:0050794
name: regulation of cellular process
namespace: biological_process
alt_id: GO:0051244
def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of cellular physiological process" EXACT []
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0009987 ! cellular process

[Term]
id: GO:0050795
name: regulation of behavior
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli." [GOC:go_curators]
subset: gosubset_prok
synonym: "regulation of behaviour" EXACT []
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0007610 ! behavior

[Term]
id: GO:0050796
name: regulation of insulin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin." [GOC:ai]
xref: Reactome:265764 "Glucose Regulation of Insulin Secretion"
xref: Reactome:448490 "Glucose Regulation of Insulin Secretion"
xref: Reactome:469620 "Glucose Regulation of Insulin Secretion"
xref: Reactome:487339 "Glucose Regulation of Insulin Secretion"
xref: Reactome:507290 "Glucose Regulation of Insulin Secretion"
xref: Reactome:517304 "Glucose Regulation of Insulin Secretion"
xref: Reactome:526189 "Glucose Regulation of Insulin Secretion"
xref: Reactome:531079 "Glucose Regulation of Insulin Secretion"
xref: Reactome:536452 "Glucose Regulation of Insulin Secretion"
xref: Reactome:542156 "Glucose Regulation of Insulin Secretion"
xref: Reactome:547514 "Glucose Regulation of Insulin Secretion"
xref: Reactome:552151 "Glucose Regulation of Insulin Secretion"
xref: Reactome:557693 "Glucose Regulation of Insulin Secretion"
xref: Reactome:568314 "Glucose Regulation of Insulin Secretion"
xref: Reactome:581516 "Glucose Regulation of Insulin Secretion"
xref: Reactome:585776 "Glucose Regulation of Insulin Secretion"
xref: Reactome:592452 "Glucose Regulation of Insulin Secretion"
xref: Reactome:595322 "Glucose Regulation of Insulin Secretion"
xref: Reactome:597292 "Glucose Regulation of Insulin Secretion"
xref: Reactome:598101 "Glucose Regulation of Insulin Secretion"
xref: Reactome:599598 "Glucose Regulation of Insulin Secretion"
xref: Reactome:600581 "Glucose Regulation of Insulin Secretion"
xref: Reactome:602449 "Glucose Regulation of Insulin Secretion"
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: regulates GO:0030073 ! insulin secretion

[Term]
id: GO:0050797
name: thymidylate synthase (FAD) activity
namespace: molecular_function
def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + FADH2 = dTMP + tetrahydrofolate + FAD." [EC:2.1.1.148]
subset: gosubset_prok
synonym: "5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.148]
synonym: "FDTS activity" EXACT [EC:2.1.1.148]
synonym: "flavin dependent thymidylate synthase activity" EXACT [EC:2.1.1.148]
synonym: "Thy1 activity" EXACT []
synonym: "ThyX activity" EXACT []
xref: EC:2.1.1.148
is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity

[Term]
id: GO:0050798
name: activated T cell proliferation
namespace: biological_process
def: "The expansion of a T cell population following activation by an antigenic stimulus." [GOC:add, GOC:dph]
comment: Note that this term is to be used for gene products involved in T cell proliferation following an antigenic stimulus, including both proteins internal to the T cell and external factors, such as IL-2, which specifically promote proliferation of activated T cells.
synonym: "activated T lymphocyte proliferation" EXACT []
synonym: "activated T-cell proliferation" EXACT []
synonym: "activated T-lymphocyte proliferation" EXACT []
is_a: GO:0042098 ! T cell proliferation

[Term]
id: GO:0050799
name: cocaine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [GOC:ai]
subset: gosubset_prok
synonym: "cocaine anabolism" EXACT []
synonym: "cocaine biosynthesis" EXACT []
synonym: "cocaine formation" EXACT []
synonym: "cocaine synthesis" EXACT []
is_a: GO:0009710 ! tropane alkaloid biosynthetic process
is_a: GO:0050783 ! cocaine metabolic process

[Term]
id: GO:0050800
name: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of GTP to directly drive the cellular or subcellular transport of a substance." [EC:3.6.5.-, GOC:ai]
comment: This term was made obsolete because it represents both process and function information.
is_obsolete: true
replaced_by: GO:0003924
replaced_by: GO:0006810

[Term]
id: GO:0050801
name: ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of ions within an organism or cell." [GOC:ai]
subset: gosubset_prok
synonym: "electrolyte homeostasis" RELATED []
synonym: "negative regulation of crystal biosynthesis" RELATED []
synonym: "negative regulation of crystal formation" RELATED []
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0050802
name: circadian sleep/wake cycle, sleep
namespace: biological_process
def: "The part of the circadian sleep/wake cycle where the organism is asleep." [GOC:ai]
is_a: GO:0022410 ! circadian sleep/wake cycle process

[Term]
id: GO:0050803
name: regulation of synapse structure and activity
namespace: biological_process
def: "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0007268 ! synaptic transmission

[Term]
id: GO:0050804
name: regulation of synaptic transmission
namespace: biological_process
def: "Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
is_a: GO:0051969 ! regulation of transmission of nerve impulse
relationship: regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0050805
name: negative regulation of synaptic transmission
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
synonym: "down regulation of synaptic transmission" EXACT []
synonym: "down-regulation of synaptic transmission" EXACT []
synonym: "downregulation of synaptic transmission" EXACT []
synonym: "inhibition of synaptic transmission" NARROW []
is_a: GO:0050804 ! regulation of synaptic transmission
is_a: GO:0051970 ! negative regulation of transmission of nerve impulse
relationship: negatively_regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0050806
name: positive regulation of synaptic transmission
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]
synonym: "activation of synaptic transmission" NARROW []
synonym: "stimulation of synaptic transmission" NARROW []
synonym: "up regulation of synaptic transmission" EXACT []
synonym: "up-regulation of synaptic transmission" EXACT []
synonym: "upregulation of synaptic transmission" EXACT []
is_a: GO:0050804 ! regulation of synaptic transmission
is_a: GO:0051971 ! positive regulation of transmission of nerve impulse
relationship: positively_regulates GO:0007268 ! synaptic transmission

[Term]
id: GO:0050807
name: regulation of synapse organization
namespace: biological_process
def: "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]
synonym: "regulation of synapse organization and biogenesis" RELATED [GOC:mah]
synonym: "regulation of synapse structure" EXACT []
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: part_of GO:0050803 ! regulation of synapse structure and activity
relationship: regulates GO:0050808 ! synapse organization

[Term]
id: GO:0050808
name: synapse organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]
synonym: "synapse development" EXACT []
synonym: "synapse organisation" EXACT [GOC:curators]
synonym: "synapse organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0043062 ! extracellular structure organization

[Term]
id: GO:0050809
name: diazepam binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "diazepam binding inhibitor activity" RELATED []
synonym: "Valium binding" EXACT []
is_a: GO:0008144 ! drug binding

[Term]
id: GO:0050810
name: regulation of steroid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of steroid anabolism" EXACT []
synonym: "regulation of steroid biosynthesis" EXACT []
synonym: "regulation of steroid formation" EXACT []
synonym: "regulation of steroid synthesis" EXACT []
synonym: "regulation of steroidogenesis" EXACT []
is_a: GO:0019218 ! regulation of steroid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: regulates GO:0006694 ! steroid biosynthetic process

[Term]
id: GO:0050811
name: GABA receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor." [GOC:ai]
synonym: "4-aminobutanoate receptor binding" EXACT []
synonym: "4-aminobutyrate receptor binding" EXACT []
synonym: "diazepam binding inhibitor activity" RELATED []
synonym: "gamma-aminobutyric acid receptor binding" EXACT []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0050812
name: regulation of acyl-CoA biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of acyl-CoA anabolism" EXACT []
synonym: "regulation of acyl-CoA biosynthesis" EXACT []
synonym: "regulation of acyl-CoA formation" EXACT []
synonym: "regulation of acyl-CoA synthesis" EXACT []
is_a: GO:0019217 ! regulation of fatty acid metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
relationship: regulates GO:0071616 ! acyl-CoA biosynthetic process

[Term]
id: GO:0050813
name: epothilone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer." [http://www.onelook.com/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "epothilone metabolism" EXACT []
is_a: GO:0009820 ! alkaloid metabolic process

[Term]
id: GO:0050814
name: epothilone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer." [GOC:ai]
subset: gosubset_prok
synonym: "epothilone anabolism" EXACT []
synonym: "epothilone biosynthesis" EXACT []
synonym: "epothilone formation" EXACT []
synonym: "epothilone synthesis" EXACT []
is_a: GO:0009821 ! alkaloid biosynthetic process
is_a: GO:0050813 ! epothilone metabolic process

[Term]
id: GO:0050815
name: phosphoserine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phosphorylated serine residue within a protein." [GOC:ai]
synonym: "phosphoserine/phosphothreonine binding" BROAD []
is_a: GO:0016597 ! amino acid binding
is_a: GO:0045309 ! protein phosphorylated amino acid binding

[Term]
id: GO:0050816
name: phosphothreonine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phosphorylated threonine residue within a protein." [GOC:ai]
synonym: "phosphoserine/phosphothreonine binding" BROAD []
is_a: GO:0045309 ! protein phosphorylated amino acid binding

[Term]
id: GO:0050817
name: coagulation
namespace: biological_process
def: "The process by which a fluid solution, or part of it, changes into a solid or semisolid mass." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: goslim_pir
synonym: "clotting" EXACT []
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0050818
name: regulation of coagulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass." [GOC:ai]
synonym: "regulation of clotting" EXACT []
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0050817 ! coagulation

[Term]
id: GO:0050819
name: negative regulation of coagulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of coagulation." [GOC:ai]
synonym: "anticoagulant activity" RELATED []
synonym: "down regulation of coagulation" EXACT []
synonym: "down-regulation of coagulation" EXACT []
synonym: "downregulation of coagulation" EXACT []
synonym: "inhibition of coagulation" NARROW []
synonym: "negative regulation of clotting." EXACT []
is_a: GO:0050818 ! regulation of coagulation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0050817 ! coagulation

[Term]
id: GO:0050820
name: positive regulation of coagulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of coagulation." [GOC:ai]
synonym: "activation of coagulation" NARROW []
synonym: "positive regulation of clotting" EXACT []
synonym: "stimulation of coagulation" NARROW []
synonym: "up regulation of coagulation" EXACT []
synonym: "up-regulation of coagulation" EXACT []
synonym: "upregulation of coagulation" EXACT []
is_a: GO:0050818 ! regulation of coagulation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0050817 ! coagulation

[Term]
id: GO:0050821
name: protein stabilization
namespace: biological_process
def: "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]
subset: gosubset_prok
synonym: "lysosomal protein stabilization" NARROW []
synonym: "positive regulation of protein stability" EXACT []
synonym: "protein sequestering" RELATED []
synonym: "protein stabilization activity" RELATED []
is_a: GO:0031647 ! regulation of protein stability

[Term]
id: GO:0050822
name: peptide stabilization
namespace: biological_process
def: "Any process involved in maintaining the structure and integrity of a peptide and preventing it from being degraded." [GOC:ai]
subset: gosubset_prok
synonym: "peptide stabilization activity" RELATED []
is_a: GO:0006518 ! peptide metabolic process

[Term]
id: GO:0050823
name: peptide antigen stabilization
namespace: biological_process
def: "Any process involved in maintaining the structure and integrity of a peptide antigen and preventing it from being degraded." [GOC:ai]
subset: gosubset_prok
synonym: "peptide antigen stabilization activity" RELATED []
is_a: GO:0050822 ! peptide stabilization
relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen

[Term]
id: GO:0050824
name: water binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with water (H2O)." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0050825
name: ice binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal." [http://cancerweb.ncl.ac.uk/]
subset: gosubset_prok
synonym: "antifreeze activity" RELATED []
synonym: "ice crystal binding" EXACT []
synonym: "ice nucleation activity" RELATED []
synonym: "ice nucleation inhibitor activity" RELATED []
is_a: GO:0050824 ! water binding

[Term]
id: GO:0050826
name: response to freezing
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:jl]
subset: gosubset_prok
synonym: "antifreeze activity" RELATED []
synonym: "ice nucleation inhibitor activity" RELATED []
is_a: GO:0009409 ! response to cold

[Term]
id: GO:0050827
name: toxin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a toxin receptor, a receptor for substances that cause injury to living organisms." [GOC:ai]
synonym: "channel-forming toxin activity" RELATED []
synonym: "cytotoxin activity" RELATED []
synonym: "endotoxin activity" RELATED []
synonym: "enterotoxin activity" RELATED []
synonym: "exotoxin activity" RELATED []
synonym: "lipoprotein toxin" RELATED []
synonym: "neurotoxin activity" RELATED []
synonym: "pore-forming toxin activity" RELATED []
synonym: "toxin activity" RELATED []
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0050828
name: regulation of liquid surface tension
namespace: biological_process
def: "Any process that modulates the surface tension of a liquid. Surface tension is the property that makes a liquid behave as if it had an elastic skin on its surface at the interface with a gas or an immiscible liquid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "regulation of surface tension of a liquid" EXACT []
synonym: "surfactant activity" RELATED []
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0050829
name: defense response to Gram-negative bacterium
namespace: biological_process
def: "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]
synonym: "defence response to Gram-negative bacteria" EXACT []
synonym: "defence response to Gram-negative bacterium" EXACT []
synonym: "defense response to Gram-negative bacteria" EXACT []
synonym: "Gram-negative antibacterial peptide activity" RELATED []
is_a: GO:0042742 ! defense response to bacterium

[Term]
id: GO:0050830
name: defense response to Gram-positive bacterium
namespace: biological_process
def: "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]
subset: gosubset_prok
synonym: "defence response to Gram-positive bacteria" EXACT []
synonym: "defence response to Gram-positive bacterium" EXACT []
synonym: "defense response to Gram-positive bacteria" EXACT []
synonym: "Gram-positive antibacterial peptide activity" RELATED []
is_a: GO:0042742 ! defense response to bacterium

[Term]
id: GO:0050831
name: male-specific defense response to bacterium
namespace: biological_process
def: "A set of reactions, specific to males, that are triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:ai]
synonym: "male-specific antibacterial peptide activity" RELATED []
synonym: "male-specific defence response to bacteria" EXACT []
synonym: "male-specific defence response to bacterium" EXACT []
synonym: "male-specific defense response to bacteria" EXACT []
is_a: GO:0042742 ! defense response to bacterium

[Term]
id: GO:0050832
name: defense response to fungus
namespace: biological_process
alt_id: GO:0042831
def: "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]
synonym: "defence response to fungi" EXACT []
synonym: "defence response to fungus" EXACT []
synonym: "defense response to fungi" EXACT []
is_a: GO:0006952 ! defense response
is_a: GO:0009620 ! response to fungus

[Term]
id: GO:0050833
name: pyruvate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other." [GOC:ai]
synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" NARROW []
xref: Reactome:162197 "pyruvate transmembrane transporter activity"
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0050834
name: molybdenum incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide
namespace: biological_process
def: "The incorporation of molybdenum into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide." [RESID:AA0355]
subset: gosubset_prok
xref: RESID:AA0355
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex

[Term]
id: GO:0050835
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide
namespace: biological_process
def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide." [RESID:AA0356]
subset: gosubset_prok
xref: RESID:AA0356
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster
is_a: GO:0050843 ! S-adenosylmethionine catabolic process

[Term]
id: GO:0050836
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide
namespace: biological_process
def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide." [RESID:AA0357]
subset: gosubset_prok
xref: RESID:AA0357
is_a: GO:0018195 ! peptidyl-arginine modification
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster

[Term]
id: GO:0050837
name: peptide cross-linking via L-cysteinyl-L-selenocysteine
namespace: biological_process
def: "The formation of a selenide-sulfide bond to form the cystine-like L-cysteinyl-L-selenocysteine, as in vertebrate selenopeptide P." [RESID:AA0358]
subset: gosubset_prok
xref: RESID:AA0358
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0050844 ! peptidyl-selenocysteine modification

[Term]
id: GO:0050838
name: peptidyl-5-hydroxy-L-lysine trimethylation
namespace: biological_process
def: "The methylation of 5-hydroxy-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine." [RESID:AA0359]
subset: gosubset_prok
xref: RESID:AA0359
is_a: GO:0018022 ! peptidyl-lysine methylation

[Term]
id: GO:0050839
name: cell adhesion molecule binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cell adhesion molecule." [GOC:ai]
synonym: "adhesive extracellular matrix constituent" RELATED []
synonym: "CAM binding" EXACT []
synonym: "cell adhesion molecule activity" RELATED []
synonym: "cell adhesion receptor activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0050840
name: extracellular matrix binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a component of the extracellular matrix." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "adhesive extracellular matrix constituent" RELATED []
synonym: "extracellular matrix constituent binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0050841
name: peptidyl-N6,N6,N6-trimethyl-lysine hydroxylation to peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine
namespace: biological_process
def: "The hydroxylation of peptidyl-N6,N6,N6-trimethyl-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine." [RESID:AA0359]
subset: gosubset_prok
synonym: "peptidyl trimethyl lysine hydroxylase activity" EXACT []
synonym: "peptidyl-trimethyl-lysine hydroxylase activity" EXACT []
xref: RESID:AA0359
is_a: GO:0017185 ! peptidyl-lysine hydroxylation

[Term]
id: GO:0050842
name: copper incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide
namespace: biological_process
def: "The incorporation of copper into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide." [RESID:AA0355]
subset: gosubset_prok
xref: RESID:AA0355
is_a: GO:0018198 ! peptidyl-cysteine modification
is_a: GO:0018427 ! copper incorporation into metallo-sulfur cluster

[Term]
id: GO:0050843
name: S-adenosylmethionine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai]
subset: gosubset_prok
synonym: "S-adenosyl methionine catabolic process" EXACT []
synonym: "S-adenosyl methionine catabolism" EXACT []
synonym: "S-adenosylmethionine breakdown" EXACT []
synonym: "S-adenosylmethionine catabolism" EXACT []
synonym: "S-adenosylmethionine degradation" EXACT []
synonym: "SAM catabolic process" EXACT []
is_a: GO:0042219 ! cellular amino acid derivative catabolic process
is_a: GO:0044273 ! sulfur compound catabolic process
is_a: GO:0046130 ! purine ribonucleoside catabolic process
is_a: GO:0046500 ! S-adenosylmethionine metabolic process

[Term]
id: GO:0050844
name: peptidyl-selenocysteine modification
namespace: biological_process
def: "The modification of peptidyl-selenocysteine." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018193 ! peptidyl-amino acid modification

[Term]
id: GO:0050845
name: teichuronic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria." [ISBN:0815108893]
subset: gosubset_prok
synonym: "teichuronic acid anabolism" EXACT []
synonym: "teichuronic acid biosynthesis" EXACT []
synonym: "teichuronic acid formation" EXACT []
synonym: "teichuronic acid synthesis" EXACT []
is_a: GO:0016053 ! organic acid biosynthetic process
is_a: GO:0044038 ! cell wall macromolecule biosynthetic process
is_a: GO:0050846 ! teichuronic acid metabolic process
relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis

[Term]
id: GO:0050846
name: teichuronic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria." [ISBN:0815108893]
subset: gosubset_prok
synonym: "teichuronic acid metabolism" EXACT []
is_a: GO:0006082 ! organic acid metabolic process

[Term]
id: GO:0050847
name: progesterone receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of a progesterone binding to its receptor." [GOC:ai, GOC:mah, PMID:14744870]
synonym: "progesterone receptor signalling pathway" EXACT []
is_a: GO:0030518 ! steroid hormone receptor signaling pathway

[Term]
id: GO:0050848
name: regulation of calcium-mediated signaling
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process by which a cell uses calcium ions to convert an extracellular signal into a response." [GOC:ai]
synonym: "regulation of calcium-mediated signalling" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0019722 ! calcium-mediated signaling

[Term]
id: GO:0050849
name: negative regulation of calcium-mediated signaling
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium-mediated signaling." [GOC:ai, PMID:11696592]
synonym: "down regulation of calcium-mediated signaling" EXACT []
synonym: "down-regulation of calcium-mediated signaling" EXACT []
synonym: "downregulation of calcium-mediated signaling" EXACT []
synonym: "inhibition of calcium-mediated signaling" NARROW []
synonym: "negative regulation of calcium-mediated signalling" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0050848 ! regulation of calcium-mediated signaling
relationship: negatively_regulates GO:0019722 ! calcium-mediated signaling

[Term]
id: GO:0050850
name: positive regulation of calcium-mediated signaling
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling." [GOC:ai]
synonym: "activation of calcium-mediated signaling" NARROW []
synonym: "positive regulation of calcium-mediated signalling" EXACT []
synonym: "stimulation of calcium-mediated signaling" NARROW []
synonym: "up regulation of calcium-mediated signaling" EXACT []
synonym: "up-regulation of calcium-mediated signaling" EXACT []
synonym: "upregulation of calcium-mediated signaling" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0050848 ! regulation of calcium-mediated signaling
relationship: positively_regulates GO:0019722 ! calcium-mediated signaling

[Term]
id: GO:0050851
name: antigen receptor-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell." [GOC:add]
synonym: "antigen receptor-mediated signalling pathway" EXACT []
is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway

[Term]
id: GO:0050852
name: T cell receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell." [GOC:add]
synonym: "T lymphocyte receptor signaling pathway" EXACT []
synonym: "T lymphocyte receptor signalling pathway" EXACT []
synonym: "T-cell receptor signaling pathway" EXACT []
synonym: "T-cell receptor signalling pathway" EXACT []
synonym: "T-lymphocyte receptor signaling pathway" EXACT []
synonym: "T-lymphocyte receptor signalling pathway" EXACT []
synonym: "TCR signaling pathway" EXACT []
xref: Reactome:202403 "TCR signaling"
xref: Reactome:448707 "TCR signaling"
xref: Reactome:469829 "TCR signaling"
xref: Reactome:487523 "TCR signaling"
xref: Reactome:507484 "TCR signaling"
xref: Reactome:517468 "TCR signaling"
xref: Reactome:526568 "TCR signaling"
xref: Reactome:531427 "TCR signaling"
xref: Reactome:536797 "TCR signaling"
xref: Reactome:542557 "TCR signaling"
xref: Reactome:547880 "TCR signaling"
xref: Reactome:552536 "TCR signaling"
xref: Reactome:557999 "TCR signaling"
xref: Reactome:568713 "TCR signaling"
xref: Reactome:581916 "TCR signaling"
xref: Reactome:585953 "TCR signaling"
xref: Reactome:592810 "TCR signaling"
is_a: GO:0050851 ! antigen receptor-mediated signaling pathway

[Term]
id: GO:0050853
name: B cell receptor signaling pathway
namespace: biological_process
def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell." [GOC:add]
synonym: "B cell receptor signalling pathway" EXACT []
synonym: "B lymphocyte receptor signaling pathway" EXACT []
synonym: "B lymphocyte receptor signalling pathway" EXACT []
synonym: "B-cell receptor signaling pathway" EXACT []
synonym: "B-cell receptor signalling pathway" EXACT []
synonym: "B-lymphocyte receptor signaling pathway" EXACT []
synonym: "B-lymphocyte receptor signalling pathway" EXACT []
is_a: GO:0050851 ! antigen receptor-mediated signaling pathway

[Term]
id: GO:0050854
name: regulation of antigen receptor-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai]
synonym: "regulation of antigen receptor mediated signalling pathway" EXACT []
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0050851 ! antigen receptor-mediated signaling pathway

[Term]
id: GO:0050855
name: regulation of B cell receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai]
synonym: "regulation of B cell receptor signalling pathway" EXACT []
synonym: "regulation of B lymphocyte receptor signaling pathway" EXACT []
synonym: "regulation of B lymphocyte receptor signalling pathway" EXACT []
synonym: "regulation of B-cell receptor signaling pathway" EXACT []
synonym: "regulation of B-cell receptor signalling pathway" EXACT []
synonym: "regulation of B-lymphocyte receptor signaling pathway" EXACT []
synonym: "regulation of B-lymphocyte receptor signalling pathway" EXACT []
is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway
relationship: regulates GO:0050853 ! B cell receptor signaling pathway

[Term]
id: GO:0050856
name: regulation of T cell receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai]
synonym: "regulation of T lymphocyte receptor signaling pathway" EXACT []
synonym: "regulation of T lymphocyte receptor signalling pathway" EXACT []
synonym: "regulation of T-cell receptor signaling pathway" EXACT []
synonym: "regulation of T-cell receptor signalling pathway" EXACT []
synonym: "regulation of T-lymphocyte receptor signaling pathway" EXACT []
synonym: "regulation of T-lymphocyte receptor signalling pathway" EXACT []
synonym: "regulation of TCR signaling pathway" EXACT []
is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway
relationship: regulates GO:0050852 ! T cell receptor signaling pathway

[Term]
id: GO:0050857
name: positive regulation of antigen receptor-mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai]
synonym: "activation of antigen receptor-mediated signaling pathway" NARROW []
synonym: "positive regulation of antigen receptor mediated signalling pathway" EXACT []
synonym: "stimulation of antigen receptor-mediated signaling pathway" NARROW []
synonym: "up regulation of antigen receptor-mediated signaling pathway" EXACT []
synonym: "up-regulation of antigen receptor-mediated signaling pathway" EXACT []
synonym: "upregulation of antigen receptor-mediated signaling pathway" EXACT []
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway
relationship: positively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway

[Term]
id: GO:0050858
name: negative regulation of antigen receptor-mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai]
synonym: "down regulation of antigen receptor-mediated signaling pathway" EXACT []
synonym: "down-regulation of antigen receptor-mediated signaling pathway" EXACT []
synonym: "downregulation of antigen receptor-mediated signaling pathway" EXACT []
synonym: "inhibition of antigen receptor-mediated signaling pathway" NARROW []
synonym: "negative regulation of antigen receptor mediated signalling pathway" EXACT []
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway
relationship: negatively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway

[Term]
id: GO:0050859
name: negative regulation of B cell receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai]
synonym: "down regulation of B cell receptor signaling pathway" EXACT []
synonym: "down-regulation of B cell receptor signaling pathway" EXACT []
synonym: "downregulation of B cell receptor signaling pathway" EXACT []
synonym: "inhibition of B cell receptor signaling pathway" NARROW []
synonym: "negative regulation of B cell receptor signalling pathway" EXACT []
synonym: "negative regulation of B lymphocyte receptor signaling pathway" EXACT []
synonym: "negative regulation of B lymphocyte receptor signalling pathway" EXACT []
synonym: "negative regulation of B-cell receptor signaling pathway" EXACT []
synonym: "negative regulation of B-cell receptor signalling pathway" EXACT []
synonym: "negative regulation of B-lymphocyte receptor signaling pathway" EXACT []
synonym: "negative regulation of B-lymphocyte receptor signalling pathway" EXACT []
is_a: GO:0050855 ! regulation of B cell receptor signaling pathway
is_a: GO:0050858 ! negative regulation of antigen receptor-mediated signaling pathway
relationship: negatively_regulates GO:0050853 ! B cell receptor signaling pathway

[Term]
id: GO:0050860
name: negative regulation of T cell receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai]
synonym: "down regulation of T cell receptor signaling pathway" EXACT []
synonym: "down-regulation of T cell receptor signaling pathway" EXACT []
synonym: "downregulation of T cell receptor signaling pathway" EXACT []
synonym: "inhibition of T cell receptor signaling pathway" NARROW []
synonym: "negative regulation of T cell receptor signalling pathway" EXACT []
synonym: "negative regulation of T lymphocyte receptor signaling pathway" EXACT []
synonym: "negative regulation of T lymphocyte receptor signalling pathway" EXACT []
synonym: "negative regulation of T-cell receptor signaling pathway" EXACT []
synonym: "negative regulation of T-lymphocyte receptor signaling pathway" EXACT []
synonym: "negative regulation of T-lymphocyte receptor signalling pathway" EXACT []
synonym: "negative regulation of TCR signaling pathway" EXACT []
is_a: GO:0050856 ! regulation of T cell receptor signaling pathway
is_a: GO:0050858 ! negative regulation of antigen receptor-mediated signaling pathway
relationship: negatively_regulates GO:0050852 ! T cell receptor signaling pathway

[Term]
id: GO:0050861
name: positive regulation of B cell receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai]
synonym: "activation of B cell receptor signaling pathway" NARROW []
synonym: "positive regulation of B cell receptor signalling pathway" EXACT []
synonym: "positive regulation of B lymphocyte receptor signaling pathway" EXACT []
synonym: "positive regulation of B lymphocyte receptor signalling pathway" EXACT []
synonym: "positive regulation of B-cell receptor signaling pathway" EXACT []
synonym: "positive regulation of B-cell receptor signalling pathway" EXACT []
synonym: "positive regulation of B-lymphocyte receptor signaling pathway" EXACT []
synonym: "positive regulation of B-lymphocyte receptor signalling pathway" EXACT []
synonym: "stimulation of B cell receptor signaling pathway" NARROW []
synonym: "up regulation of B cell receptor signaling pathway" EXACT []
synonym: "up-regulation of B cell receptor signaling pathway" EXACT []
synonym: "upregulation of B cell receptor signaling pathway" EXACT []
is_a: GO:0050855 ! regulation of B cell receptor signaling pathway
is_a: GO:0050857 ! positive regulation of antigen receptor-mediated signaling pathway
relationship: positively_regulates GO:0050853 ! B cell receptor signaling pathway

[Term]
id: GO:0050862
name: positive regulation of T cell receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai]
synonym: "activation of T cell receptor signaling pathway" NARROW []
synonym: "positive regulation of T cell receptor signalling pathway" EXACT []
synonym: "positive regulation of T lymphocyte receptor signaling pathway" EXACT []
synonym: "positive regulation of T lymphocyte receptor signalling pathway" EXACT []
synonym: "positive regulation of T-cell receptor signaling pathway" EXACT []
synonym: "positive regulation of T-lymphocyte receptor signaling pathway" EXACT []
synonym: "positive regulation of T-lymphocyte receptor signalling pathway" EXACT []
synonym: "positive regulation of TCR signaling pathway" EXACT []
synonym: "stimulation of T cell receptor signaling pathway" NARROW []
synonym: "up regulation of T cell receptor signaling pathway" EXACT []
synonym: "up-regulation of T cell receptor signaling pathway" EXACT []
synonym: "upregulation of T cell receptor signaling pathway" EXACT []
is_a: GO:0050856 ! regulation of T cell receptor signaling pathway
is_a: GO:0050857 ! positive regulation of antigen receptor-mediated signaling pathway
relationship: positively_regulates GO:0050852 ! T cell receptor signaling pathway

[Term]
id: GO:0050863
name: regulation of T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of T cell activation." [GOC:ai]
synonym: "regulation of T lymphocyte activation" EXACT []
synonym: "regulation of T-cell activation" EXACT []
synonym: "regulation of T-lymphocyte activation" EXACT []
is_a: GO:0051249 ! regulation of lymphocyte activation
relationship: regulates GO:0042110 ! T cell activation

[Term]
id: GO:0050864
name: regulation of B cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of B cell activation." [GOC:ai]
synonym: "regulation of B lymphocyte activation" EXACT []
synonym: "regulation of B-cell activation" EXACT []
synonym: "regulation of B-lymphocyte activation" EXACT []
is_a: GO:0051249 ! regulation of lymphocyte activation
relationship: regulates GO:0042113 ! B cell activation

[Term]
id: GO:0050865
name: regulation of cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:ai]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0001775 ! cell activation

[Term]
id: GO:0050866
name: negative regulation of cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell activation." [GOC:ai]
synonym: "down regulation of cell activation" EXACT []
synonym: "down-regulation of cell activation" EXACT []
synonym: "downregulation of cell activation" EXACT []
synonym: "inhibition of cell activation" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0050865 ! regulation of cell activation
relationship: negatively_regulates GO:0001775 ! cell activation

[Term]
id: GO:0050867
name: positive regulation of cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activation." [GOC:ai]
synonym: "activation of cell activation" NARROW []
synonym: "stimulation of cell activation" NARROW []
synonym: "up regulation of cell activation" EXACT []
synonym: "up-regulation of cell activation" EXACT []
synonym: "upregulation of cell activation" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0050865 ! regulation of cell activation
relationship: positively_regulates GO:0001775 ! cell activation

[Term]
id: GO:0050868
name: negative regulation of T cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation." [GOC:ai]
synonym: "down regulation of T cell activation" EXACT []
synonym: "down-regulation of T cell activation" EXACT []
synonym: "downregulation of T cell activation" EXACT []
synonym: "inhibition of T cell activation" NARROW []
synonym: "negative regulation of T lymphocyte activation" EXACT []
synonym: "negative regulation of T-cell activation" EXACT []
synonym: "negative regulation of T-lymphocyte activation" EXACT []
is_a: GO:0050863 ! regulation of T cell activation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
relationship: negatively_regulates GO:0042110 ! T cell activation

[Term]
id: GO:0050869
name: negative regulation of B cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of B cell activation." [GOC:ai]
synonym: "down regulation of B cell activation" EXACT []
synonym: "down-regulation of B cell activation" EXACT []
synonym: "downregulation of B cell activation" EXACT []
synonym: "inhibition of B cell activation" NARROW []
synonym: "negative regulation of B lymphocyte activation" EXACT []
synonym: "negative regulation of B-cell activation" EXACT []
synonym: "negative regulation of B-lymphocyte activation" EXACT []
is_a: GO:0050864 ! regulation of B cell activation
is_a: GO:0051250 ! negative regulation of lymphocyte activation
relationship: negatively_regulates GO:0042113 ! B cell activation

[Term]
id: GO:0050870
name: positive regulation of T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell activation." [GOC:ai]
synonym: "activation of T cell activation" NARROW []
synonym: "positive regulation of T lymphocyte activation" EXACT []
synonym: "positive regulation of T-cell activation" EXACT []
synonym: "positive regulation of T-lymphocyte activation" EXACT []
synonym: "stimulation of T cell activation" NARROW []
synonym: "up regulation of T cell activation" EXACT []
synonym: "up-regulation of T cell activation" EXACT []
synonym: "upregulation of T cell activation" EXACT []
is_a: GO:0050863 ! regulation of T cell activation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
relationship: positively_regulates GO:0042110 ! T cell activation

[Term]
id: GO:0050871
name: positive regulation of B cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of B cell activation." [GOC:ai]
synonym: "activation of B cell activation" NARROW []
synonym: "positive regulation of B lymphocyte activation" EXACT []
synonym: "positive regulation of B-cell activation" EXACT []
synonym: "positive regulation of B-lymphocyte activation" EXACT []
synonym: "stimulation of B cell activation" NARROW []
synonym: "up regulation of B cell activation" EXACT []
synonym: "up-regulation of B cell activation" EXACT []
synonym: "upregulation of B cell activation" EXACT []
is_a: GO:0050864 ! regulation of B cell activation
is_a: GO:0051251 ! positive regulation of lymphocyte activation
relationship: positively_regulates GO:0042113 ! B cell activation

[Term]
id: GO:0050872
name: white fat cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole." [PMID:12508945]
synonym: "white adipocyte cell differentiation" EXACT []
synonym: "white adipocyte differentiation" EXACT []
is_a: GO:0045444 ! fat cell differentiation

[Term]
id: GO:0050873
name: brown fat cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [PMID:12588810]
synonym: "brown adipocyte cell differentiation" EXACT []
synonym: "brown adipocyte differentiation" EXACT []
is_a: GO:0045444 ! fat cell differentiation

[Term]
id: GO:0050877
name: neurological system process
namespace: biological_process
def: "A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]
subset: goslim_pir
synonym: "neurophysiological process" EXACT []
synonym: "pan-neural process" RELATED []
is_a: GO:0003008 ! system process

[Term]
id: GO:0050878
name: regulation of body fluid levels
namespace: biological_process
def: "Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb]
subset: goslim_pir
is_a: GO:0032501 ! multicellular organismal process
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0050879
name: multicellular organismal movement
namespace: biological_process
def: "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism." [GOC:dph, GOC:mtg_muscle, GOC:tb]
subset: goslim_pir
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0050880
name: regulation of blood vessel size
namespace: biological_process
def: "Any process that modulates the size of blood vessels." [GOC:ai]
is_a: GO:0003018 ! vascular process in circulatory system
is_a: GO:0035150 ! regulation of tube size
relationship: part_of GO:0008015 ! blood circulation

[Term]
id: GO:0050881
name: musculoskeletal movement
namespace: biological_process
def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system." [GOC:dph]
is_a: GO:0050879 ! multicellular organismal movement

[Term]
id: GO:0050882
name: voluntary musculoskeletal movement
namespace: biological_process
def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will." [GOC:dph]
is_a: GO:0050881 ! musculoskeletal movement

[Term]
id: GO:0050883
name: musculoskeletal movement, spinal reflex action
namespace: biological_process
def: "Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord." [GOC:dph]
is_a: GO:0050881 ! musculoskeletal movement
is_a: GO:0060004 ! reflex

[Term]
id: GO:0050884
name: neuromuscular process controlling posture
namespace: biological_process
def: "Any process by which an organism voluntarily modulates its posture, the alignment of its anatomical parts." [GOC:dph, GOC:tb]
synonym: "regulation of posture" EXACT []
is_a: GO:0050905 ! neuromuscular process

[Term]
id: GO:0050885
name: neuromuscular process controlling balance
namespace: biological_process
def: "Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors." [GOC:ai, GOC:dph, http://www.onelook.com/]
synonym: "regulation of balance" RELATED []
is_a: GO:0050905 ! neuromuscular process

[Term]
id: GO:0050886
name: endocrine process
namespace: biological_process
def: "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: goslim_pir
synonym: "endocrine physiological process" EXACT []
synonym: "endocrine physiology" EXACT []
is_a: GO:0003008 ! system process

[Term]
id: GO:0050887
name: determination of sensory modality
namespace: biological_process
def: "The determination of the type or quality of a sensation. Sensory modalities include touch, thermal sensation, visual sensation, auditory sensation and pain." [ISBN:0721619908]
is_a: GO:0050893 ! sensory processing

[Term]
id: GO:0050888
name: determination of stimulus location
namespace: biological_process
def: "The determination of where on the body surface, within the body or in the environment a stimulus originates." [ISBN:0721619908]
is_a: GO:0050893 ! sensory processing

[Term]
id: GO:0050889
name: determination of stimulus intensity
namespace: biological_process
def: "The determination of the perceived strength of a sensory stimulus." [ISBN:0721619908]
is_a: GO:0050893 ! sensory processing

[Term]
id: GO:0050890
name: cognition
namespace: biological_process
def: "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [http://www.onelook.com/, ISBN:0721619908]
xref: Wikipedia:Cognition
is_a: GO:0050877 ! neurological system process

[Term]
id: GO:0050891
name: multicellular organismal water homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of water within a tissue, organ, or a multicellular organism." [GOC:dph, GOC:tb]
synonym: "body fluid osmoregulation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0030104 ! water homeostasis
is_a: GO:0050878 ! regulation of body fluid levels

[Term]
id: GO:0050892
name: intestinal absorption
namespace: biological_process
def: "Any process by which nutrients are taken up from the contents of the intestine." [GOC:ai, GOC:dph]
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0050893
name: sensory processing
namespace: biological_process
def: "Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0050877 ! neurological system process
relationship: part_of GO:0007600 ! sensory perception

[Term]
id: GO:0050894
name: determination of affect
namespace: biological_process
def: "Any process by which an emotional response is associated with a particular sensory stimulation." [GOC:ai, GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0050893 ! sensory processing

[Term]
id: GO:0050896
name: response to stimulus
namespace: biological_process
alt_id: GO:0051869
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:ai]
subset: goslim_goa
subset: goslim_pir
subset: gosubset_prok
synonym: "physiological response to stimulus" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0050897
name: cobalt ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cobalt (Co) ion." [GOC:ai]
subset: gosubset_prok
synonym: "cobalt binding" EXACT []
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0050898
name: nitrile metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nitriles, an organic compound containing trivalent nitrogen attached to one carbon atom. The nitriles are named with reference to the acids produced by their decomposition; for example, hydrocyanic acid is formic nitrile, and methyl cyanide is acetic nitrile." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "nitrile metabolism" EXACT []
is_a: GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0050899
name: nitrile catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "nitrile breakdown" EXACT []
synonym: "nitrile catabolism" EXACT []
synonym: "nitrile degradation" EXACT []
is_a: GO:0044270 ! cellular nitrogen compound catabolic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0050900
name: leukocyte migration
namespace: biological_process
def: "The movement of a leukocyte within or between different tissues and organs of the body." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "immune cell migration" EXACT []
synonym: "immune cell trafficking" EXACT []
synonym: "leucocyte migration" EXACT []
synonym: "leucocyte trafficking" EXACT []
synonym: "leukocyte trafficking" EXACT []
xref: Reactome:202733 "Cell surface interactions at the vascular wall"
xref: Reactome:448892 "Cell surface interactions at the vascular wall"
xref: Reactome:470009 "Cell surface interactions at the vascular wall"
xref: Reactome:487770 "Cell surface interactions at the vascular wall"
xref: Reactome:507666 "Cell surface interactions at the vascular wall"
is_a: GO:0002376 ! immune system process
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0050901
name: leukocyte tethering or rolling
namespace: biological_process
def: "Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation." [ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
is_a: GO:0007159 ! leukocyte adhesion
relationship: part_of GO:0045123 ! cellular extravasation

[Term]
id: GO:0050902
name: leukocyte adhesive activation
namespace: biological_process
def: "The activation of loosely bound or rolling leukocytes by signals displayed on blood vessel endothelial cells, which is typically the second step in cellular extravasation." [ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
synonym: "leukocyte adhesive triggering" EXACT []
is_a: GO:0045321 ! leukocyte activation
relationship: part_of GO:0045123 ! cellular extravasation

[Term]
id: GO:0050903
name: leukocyte activation-dependent arrest
namespace: biological_process
def: "The formation of an integrin-dependent strong adhesive bond between leukocytes and blood vessel endothelial cells which is dependent on prior activation of the leukocyte and leads to the firm attachment of the leukocyte to the endothelial surface, typically the third step in cellular extravasation." [ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
is_a: GO:0007159 ! leukocyte adhesion
relationship: part_of GO:0045123 ! cellular extravasation

[Term]
id: GO:0050904
name: diapedesis
namespace: biological_process
def: "The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation." [ISBN:078173514, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
comment: Note that the term diapedesis, although sometimes used as a direct synonym for cellular extravasation, is used here for the specific final step of the process, in concordance with recent reviews of the topic.
is_a: GO:0050900 ! leukocyte migration
relationship: part_of GO:0045123 ! cellular extravasation

[Term]
id: GO:0050905
name: neuromuscular process
namespace: biological_process
def: "Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai]
synonym: "neuromotor process" EXACT []
synonym: "neuromuscular physiological process" EXACT []
is_a: GO:0050877 ! neurological system process

[Term]
id: GO:0050906
name: detection of stimulus involved in sensory perception
namespace: biological_process
def: "The series of events involved in sensory perception in which a sensory stimulus is received by a cell and converted into a molecular signal." [GOC:ai, GOC:dph]
synonym: "sensory detection of stimulus" EXACT []
synonym: "sensory perception, sensory transduction of stimulus" EXACT []
synonym: "sensory perception, stimulus detection" EXACT []
synonym: "sensory transduction" EXACT []
xref: Wikipedia:Transduction_(physiology)
is_a: GO:0051606 ! detection of stimulus
relationship: part_of GO:0007600 ! sensory perception

[Term]
id: GO:0050907
name: detection of chemical stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a sensory chemical stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "sensory detection of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of chemical stimulus" EXACT []
synonym: "sensory perception, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory transduction of chemical stimulus" EXACT []
synonym: "sensory transduction of chemical stimulus during sensory perception" EXACT []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
relationship: part_of GO:0007606 ! sensory perception of chemical stimulus

[Term]
id: GO:0050908
name: detection of light stimulus involved in visual perception
namespace: biological_process
def: "The series of events involved in visual perception in which a sensory light stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "sensory detection of light during visual perception" EXACT []
synonym: "sensory detection of light stimulus during visual perception" EXACT []
synonym: "sensory transduction of light during visual perception" EXACT []
synonym: "sensory transduction of light stimulus during visual perception" EXACT []
synonym: "visual perception, detection of light stimulus" EXACT []
synonym: "visual perception, sensory transduction during perception of light" EXACT []
synonym: "visual perception, sensory transduction of light stimulus" EXACT []
is_a: GO:0009584 ! detection of visible light
is_a: GO:0050962 ! detection of light stimulus involved in sensory perception
relationship: part_of GO:0007601 ! visual perception

[Term]
id: GO:0050909
name: sensory perception of taste
namespace: biological_process
def: "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]
synonym: "gustation" EXACT []
synonym: "sense of taste" EXACT []
synonym: "taste" EXACT []
synonym: "taste perception" EXACT []
xref: Wikipedia:Taste
is_a: GO:0007606 ! sensory perception of chemical stimulus

[Term]
id: GO:0050910
name: detection of mechanical stimulus involved in sensory perception of sound
namespace: biological_process
alt_id: GO:0009592
alt_id: GO:0055128
def: "The series of events involved in the perception of sound vibration. The vibration is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "detection of sound" EXACT []
synonym: "hearing, sensory transduction of sound" EXACT []
synonym: "perception of sound, detection of mechanical stimulus" EXACT []
synonym: "perception of sound, sensory detection of mechanical stimulus" EXACT []
synonym: "perception of sound, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during perception of sound" EXACT []
synonym: "sensory transduction of mechanical stimulus during perception of sound" EXACT []
synonym: "sensory transduction of sound" EXACT []
is_a: GO:0050877 ! neurological system process
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: part_of GO:0007605 ! sensory perception of sound

[Term]
id: GO:0050911
name: detection of chemical stimulus involved in sensory perception of smell
namespace: biological_process
def: "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "perception of smell, detection of chemical stimulus" EXACT []
synonym: "perception of smell, sensory detection of chemical stimulus" EXACT []
synonym: "perception of smell, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of smell" EXACT []
synonym: "sensory detection of scent" EXACT []
synonym: "sensory detection of smell" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of smell" EXACT []
synonym: "sensory transduction of scent" EXACT []
synonym: "sensory transduction of smell" EXACT []
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
relationship: part_of GO:0007608 ! sensory perception of smell

[Term]
id: GO:0050912
name: detection of chemical stimulus involved in sensory perception of taste
namespace: biological_process
def: "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "perception of taste, detection of chemical stimulus" EXACT []
synonym: "perception of taste, sensory detection of chemical stimulus" EXACT []
synonym: "perception of taste, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of taste" EXACT []
synonym: "sensory detection of taste" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of taste" EXACT []
synonym: "sensory transduction of taste" EXACT []
synonym: "taste perception" BROAD []
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
relationship: part_of GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050913
name: sensory perception of bitter taste
namespace: biological_process
def: "The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "bitter taste perception" EXACT []
is_a: GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050914
name: sensory perception of salty taste
namespace: biological_process
def: "The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "salty taste perception" EXACT []
is_a: GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050915
name: sensory perception of sour taste
namespace: biological_process
def: "The series of events required to receive a sour taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "sour taste perception" EXACT []
is_a: GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050916
name: sensory perception of sweet taste
namespace: biological_process
def: "The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "sweet taste perception" EXACT []
is_a: GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050917
name: sensory perception of umami taste
namespace: biological_process
def: "The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process." [GOC:ai]
synonym: "umami taste perception" EXACT []
is_a: GO:0050909 ! sensory perception of taste

[Term]
id: GO:0050918
name: positive chemotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a higher concentration, in a concentration gradient of a specific chemical." [GOC:ai, GOC:isa_complete]
subset: gosubset_prok
synonym: "chemoattraction" EXACT []
is_a: GO:0006935 ! chemotaxis

[Term]
id: GO:0050919
name: negative chemotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a lower concentration, in a concentration gradient of a specific chemical." [GOC:ai, GOC:isa_complete]
synonym: "chemoaversion" EXACT []
synonym: "chemorepulsion" EXACT []
is_a: GO:0006935 ! chemotaxis

[Term]
id: GO:0050920
name: regulation of chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]
subset: gosubset_prok
is_a: GO:0032101 ! regulation of response to external stimulus
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0050795 ! regulation of behavior
relationship: regulates GO:0006935 ! chemotaxis

[Term]
id: GO:0050921
name: positive regulation of chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]
subset: gosubset_prok
synonym: "activation of chemotaxis" NARROW []
synonym: "stimulation of chemotaxis" NARROW []
synonym: "up regulation of chemotaxis" EXACT []
synonym: "up-regulation of chemotaxis" EXACT []
synonym: "upregulation of chemotaxis" EXACT []
is_a: GO:0032103 ! positive regulation of response to external stimulus
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0048520 ! positive regulation of behavior
is_a: GO:0050920 ! regulation of chemotaxis
relationship: positively_regulates GO:0006935 ! chemotaxis

[Term]
id: GO:0050922
name: negative regulation of chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]
synonym: "down regulation of chemotaxis" EXACT []
synonym: "down-regulation of chemotaxis" EXACT []
synonym: "downregulation of chemotaxis" EXACT []
synonym: "inhibition of chemotaxis" NARROW []
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0048521 ! negative regulation of behavior
is_a: GO:0050920 ! regulation of chemotaxis
relationship: negatively_regulates GO:0006935 ! chemotaxis

[Term]
id: GO:0050923
name: regulation of negative chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai]
is_a: GO:0050920 ! regulation of chemotaxis
relationship: regulates GO:0050919 ! negative chemotaxis

[Term]
id: GO:0050924
name: positive regulation of negative chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai]
synonym: "activation of negative chemotaxis" NARROW []
synonym: "stimulation of negative chemotaxis" NARROW []
synonym: "up regulation of negative chemotaxis" EXACT []
synonym: "up-regulation of negative chemotaxis" EXACT []
synonym: "upregulation of negative chemotaxis" EXACT []
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:0050923 ! regulation of negative chemotaxis
relationship: positively_regulates GO:0050919 ! negative chemotaxis

[Term]
id: GO:0050925
name: negative regulation of negative chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai]
synonym: "down regulation of negative chemotaxis" EXACT []
synonym: "down-regulation of negative chemotaxis" EXACT []
synonym: "downregulation of negative chemotaxis" EXACT []
synonym: "inhibition of negative chemotaxis" NARROW []
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:0050923 ! regulation of negative chemotaxis
relationship: negatively_regulates GO:0050919 ! negative chemotaxis

[Term]
id: GO:0050926
name: regulation of positive chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai]
subset: gosubset_prok
is_a: GO:0050920 ! regulation of chemotaxis
relationship: regulates GO:0050918 ! positive chemotaxis

[Term]
id: GO:0050927
name: positive regulation of positive chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai]
subset: gosubset_prok
synonym: "activation of positive chemotaxis" NARROW []
synonym: "stimulation of positive chemotaxis" NARROW []
synonym: "up regulation of positive chemotaxis" EXACT []
synonym: "up-regulation of positive chemotaxis" EXACT []
synonym: "upregulation of positive chemotaxis" EXACT []
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:0050926 ! regulation of positive chemotaxis
relationship: positively_regulates GO:0050918 ! positive chemotaxis

[Term]
id: GO:0050928
name: negative regulation of positive chemotaxis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai]
synonym: "down regulation of positive chemotaxis" EXACT []
synonym: "down-regulation of positive chemotaxis" EXACT []
synonym: "downregulation of positive chemotaxis" EXACT []
synonym: "inhibition of positive chemotaxis" NARROW []
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:0050926 ! regulation of positive chemotaxis
relationship: negatively_regulates GO:0050918 ! positive chemotaxis

[Term]
id: GO:0050929
name: induction of negative chemotaxis
namespace: biological_process
def: "Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai]
is_a: GO:0050924 ! positive regulation of negative chemotaxis

[Term]
id: GO:0050930
name: induction of positive chemotaxis
namespace: biological_process
def: "Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai]
subset: gosubset_prok
is_a: GO:0050927 ! positive regulation of positive chemotaxis

[Term]
id: GO:0050931
name: pigment cell differentiation
namespace: biological_process
alt_id: GO:0043357
alt_id: GO:0043358
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte." [GOC:dgh]
comment: Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore.
synonym: "chromatophore differentiation" EXACT []
synonym: "pigmented cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0048066 ! pigmentation during development

[Term]
id: GO:0050932
name: regulation of pigment cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pigmented cell differentiation." [GOC:ai]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0048070 ! regulation of pigmentation during development
relationship: regulates GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050933
name: early stripe melanocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of an early stripe melanocyte (ESM). In zebrafish, ESMs develop during the first phase (2-3 weeks of development) of the larva to adult transition (2-4 weeks of development)." [PMID:11858836]
synonym: "early stripe melanocyte cell differentiation" EXACT []
synonym: "early stripe melanophore differentiation" EXACT []
is_a: GO:0030318 ! melanocyte differentiation

[Term]
id: GO:0050934
name: late stripe melanocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a late stripe melanocyte (LSM). In zebrafish, LSMs develop during the second phase (3-4 weeks of development) of the larva-to-adult transition (2-4 weeks of development)." [PMID:11858836]
synonym: "late stripe melanocyte cell differentiation" EXACT []
synonym: "late stripe melanophore differentiation" EXACT []
is_a: GO:0030318 ! melanocyte differentiation

[Term]
id: GO:0050935
name: iridophore differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of an iridophore. Iridophores are pigment cells derived from the neural crest. They contain guanidine or other purine crystals deposited in stacks called reflecting platets or iridisomes. This gives them a silver, gold, or iridescent appearance." [GOC:jic, GOC:mh, PMID:11858836]
synonym: "iridophore cell differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050936
name: xanthophore differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a xanthophore cell. Xanthophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or xanthosomes. This makes them yellow to orange in appearance." [GOC:jic, GOC:mh, PMID:11858836]
comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure.
synonym: "xanthophore cell differentiation" EXACT []
is_a: GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050937
name: regulation of iridophore differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of iridophore differentiation." [GOC:ai]
is_a: GO:0050932 ! regulation of pigment cell differentiation
relationship: regulates GO:0050935 ! iridophore differentiation

[Term]
id: GO:0050938
name: regulation of xanthophore differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of xanthophore differentiation." [GOC:ai]
comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure.
is_a: GO:0050932 ! regulation of pigment cell differentiation
relationship: regulates GO:0050936 ! xanthophore differentiation

[Term]
id: GO:0050939
name: regulation of early stripe melanocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai]
synonym: "regulation of early stripe melanophore differentiation" EXACT []
is_a: GO:0045634 ! regulation of melanocyte differentiation
relationship: regulates GO:0050933 ! early stripe melanocyte differentiation

[Term]
id: GO:0050940
name: regulation of late stripe melanocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai]
synonym: "regulation of late stripe melanophore differentiation" EXACT []
is_a: GO:0045634 ! regulation of melanocyte differentiation
relationship: regulates GO:0050934 ! late stripe melanocyte differentiation

[Term]
id: GO:0050941
name: negative regulation of pigment cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of pigment cell differentiation." [GOC:ai]
synonym: "down regulation of pigment cell differentiation" EXACT []
synonym: "down-regulation of pigment cell differentiation" EXACT []
synonym: "downregulation of pigment cell differentiation" EXACT []
synonym: "inhibition of pigment cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0048086 ! negative regulation of pigmentation during development
is_a: GO:0050932 ! regulation of pigment cell differentiation
relationship: negatively_regulates GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050942
name: positive regulation of pigment cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation." [GOC:ai]
synonym: "activation of pigment cell differentiation" NARROW []
synonym: "stimulation of pigment cell differentiation" NARROW []
synonym: "up regulation of pigment cell differentiation" EXACT []
synonym: "up-regulation of pigment cell differentiation" EXACT []
synonym: "upregulation of pigment cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0048087 ! positive regulation of pigmentation during development
is_a: GO:0050932 ! regulation of pigment cell differentiation
relationship: positively_regulates GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0050943
name: negative regulation of iridophore differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of iridophore differentiation." [GOC:ai]
synonym: "down regulation of iridophore differentiation" EXACT []
synonym: "down-regulation of iridophore differentiation" EXACT []
synonym: "downregulation of iridophore differentiation" EXACT []
synonym: "inhibition of iridophore differentiation" NARROW []
is_a: GO:0050937 ! regulation of iridophore differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
relationship: negatively_regulates GO:0050935 ! iridophore differentiation

[Term]
id: GO:0050944
name: negative regulation of xanthophore differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of xanthophore differentiation." [GOC:ai]
comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure.
synonym: "down regulation of xanthophore differentiation" EXACT []
synonym: "down-regulation of xanthophore differentiation" EXACT []
synonym: "downregulation of xanthophore differentiation" EXACT []
synonym: "inhibition of xanthophore differentiation" NARROW []
is_a: GO:0050938 ! regulation of xanthophore differentiation
is_a: GO:0050941 ! negative regulation of pigment cell differentiation
relationship: negatively_regulates GO:0050936 ! xanthophore differentiation

[Term]
id: GO:0050945
name: positive regulation of iridophore differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of iridophore differentiation." [GOC:ai]
synonym: "activation of iridophore differentiation" NARROW []
synonym: "stimulation of iridophore differentiation" NARROW []
synonym: "up regulation of iridophore differentiation" EXACT []
synonym: "up-regulation of iridophore differentiation" EXACT []
synonym: "upregulation of iridophore differentiation" EXACT []
is_a: GO:0050937 ! regulation of iridophore differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
relationship: positively_regulates GO:0050935 ! iridophore differentiation

[Term]
id: GO:0050946
name: positive regulation of xanthophore differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of xanthophore differentiation." [GOC:ai]
comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure.
synonym: "activation of xanthophore differentiation" NARROW []
synonym: "stimulation of xanthophore differentiation" NARROW []
synonym: "up regulation of xanthophore differentiation" EXACT []
synonym: "up-regulation of xanthophore differentiation" EXACT []
synonym: "upregulation of xanthophore differentiation" EXACT []
is_a: GO:0050938 ! regulation of xanthophore differentiation
is_a: GO:0050942 ! positive regulation of pigment cell differentiation
relationship: positively_regulates GO:0050936 ! xanthophore differentiation

[Term]
id: GO:0050947
name: negative regulation of early stripe melanocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai]
synonym: "down regulation of early stripe melanocyte differentiation" EXACT []
synonym: "down-regulation of early stripe melanocyte differentiation" EXACT []
synonym: "downregulation of early stripe melanocyte differentiation" EXACT []
synonym: "inhibition of early stripe melanocyte differentiation" NARROW []
synonym: "negative regulation of early stripe melanophore differentiation" EXACT []
is_a: GO:0045635 ! negative regulation of melanocyte differentiation
is_a: GO:0050939 ! regulation of early stripe melanocyte differentiation
relationship: negatively_regulates GO:0050933 ! early stripe melanocyte differentiation

[Term]
id: GO:0050948
name: positive regulation of early stripe melanocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai]
synonym: "activation of early stripe melanocyte differentiation" NARROW []
synonym: "positive regulation of early stripe melanophore differentiation" EXACT []
synonym: "stimulation of early stripe melanocyte differentiation" NARROW []
synonym: "up regulation of early stripe melanocyte differentiation" EXACT []
synonym: "up-regulation of early stripe melanocyte differentiation" EXACT []
synonym: "upregulation of early stripe melanocyte differentiation" EXACT []
is_a: GO:0045636 ! positive regulation of melanocyte differentiation
is_a: GO:0050939 ! regulation of early stripe melanocyte differentiation
relationship: positively_regulates GO:0050933 ! early stripe melanocyte differentiation

[Term]
id: GO:0050949
name: negative regulation of late stripe melanocyte differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai]
synonym: "down regulation of late stripe melanocyte differentiation" EXACT []
synonym: "down-regulation of late stripe melanocyte differentiation" EXACT []
synonym: "downregulation of late stripe melanocyte differentiation" EXACT []
synonym: "inhibition of late stripe melanocyte differentiation" NARROW []
synonym: "negative regulation of late stripe melanophore differentiation" EXACT []
is_a: GO:0045635 ! negative regulation of melanocyte differentiation
is_a: GO:0050940 ! regulation of late stripe melanocyte differentiation
relationship: negatively_regulates GO:0050934 ! late stripe melanocyte differentiation

[Term]
id: GO:0050950
name: positive regulation of late stripe melanocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai]
synonym: "activation of late stripe melanocyte differentiation" NARROW []
synonym: "positive regulation of late stripe melanophore differentiation" EXACT []
synonym: "stimulation of late stripe melanocyte differentiation" NARROW []
synonym: "up regulation of late stripe melanocyte differentiation" EXACT []
synonym: "up-regulation of late stripe melanocyte differentiation" EXACT []
synonym: "upregulation of late stripe melanocyte differentiation" EXACT []
is_a: GO:0045636 ! positive regulation of melanocyte differentiation
is_a: GO:0050940 ! regulation of late stripe melanocyte differentiation
relationship: positively_regulates GO:0050934 ! late stripe melanocyte differentiation

[Term]
id: GO:0050951
name: sensory perception of temperature stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "sensory perception of thermal stimulus" EXACT []
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050952
name: sensory perception of electrical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050953
name: sensory perception of light stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050954
name: sensory perception of mechanical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]
synonym: "chemi-mechanical coupling" RELATED []
synonym: "mechanosensory perception" EXACT []
synonym: "perception of mechanical stimulus" EXACT []
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050955
name: thermoception
namespace: biological_process
def: "The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature)." [GOC:ai, http://www.wikipedia.org/Thermoception]
synonym: "thermoreception" EXACT []
xref: Wikipedia:Thermoception
is_a: GO:0050951 ! sensory perception of temperature stimulus

[Term]
id: GO:0050956
name: electroception
namespace: biological_process
def: "The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location." [GOC:ai, http://www.wikipedia.org/Electroreception]
synonym: "electroception sense" EXACT []
synonym: "electroceptive sense" EXACT []
xref: Wikipedia:Electroreception
is_a: GO:0050952 ! sensory perception of electrical stimulus

[Term]
id: GO:0050957
name: equilibrioception
namespace: biological_process
def: "The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion." [http://www.medterms.com, http://www.onelook.com/]
synonym: "sensory perception of orientation with respect to gravity" EXACT []
xref: Wikipedia:Equilibrioception
is_a: GO:0007600 ! sensory perception
relationship: part_of GO:0050885 ! neuromuscular process controlling balance

[Term]
id: GO:0050958
name: magnetoreception
namespace: biological_process
def: "The series of events required for an organism to receive a stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Stimuli may be chemical, mechanical or electrical and interpreting these stimuli allows an organism to determine the orientation of a magnetic field. Magnetoreception also involves the perception of light; birds cannot orient without the presence of short wavelength (blue/green) light." [GOC:ai, http://www.wikipedia.org/Magnetoception]
synonym: "magnetoception" EXACT []
synonym: "sensory perception of magnetic field" EXACT []
xref: Wikipedia:Magnetoception
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0050959
name: echolocation
namespace: biological_process
def: "Echolocation is the method used by some animals (e.g. bats, dolphins and some whales) to determine the location of something by measuring the time it takes for an echo to return from it. These animals emit sound waves and listen for the echo, calculating the distance to the object from the time lapse between sound emission and the echo returning." [http://www.onelook.com/, http://www.wikipedia.org/Animal_echolocation]
synonym: "perception of environment using reflected sound waves" EXACT []
xref: Wikipedia:Echolocation
is_a: GO:0050877 ! neurological system process

[Term]
id: GO:0050960
name: detection of temperature stimulus involved in thermoception
namespace: biological_process
def: "The series of events v thermoception in which a sensory temperature stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "sensory detection of heat stimulus during thermoception" NARROW []
synonym: "sensory detection of temperature stimulus during thermoception" EXACT []
synonym: "sensory detection of thermal stimulus during thermoception" EXACT []
synonym: "sensory transduction of heat stimulus during thermoception" NARROW []
synonym: "sensory transduction of temperature stimulus during thermoception" EXACT []
synonym: "sensory transduction of thermal stimulus during thermoception" EXACT []
synonym: "thermoception, sensory detection of heat stimulus" NARROW []
synonym: "thermoception, sensory detection of temperature stimulus" EXACT []
synonym: "thermoception, sensory detection of thermal stimulus" EXACT []
synonym: "thermoception, sensory transduction of heat stimulus" NARROW []
synonym: "thermoception, sensory transduction of temperature stimulus" EXACT []
synonym: "thermoception, sensory transduction of thermal stimulus" EXACT []
is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception
relationship: part_of GO:0050955 ! thermoception

[Term]
id: GO:0050961
name: detection of temperature stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a sensory temperature stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "sensory detection of heat stimulus during sensory perception" NARROW []
synonym: "sensory detection of temperature stimulus" EXACT []
synonym: "sensory detection of temperature stimulus during sensory perception" EXACT []
synonym: "sensory detection of thermal stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of heat stimulus" NARROW []
synonym: "sensory perception, sensory detection of temperature stimulus" EXACT []
synonym: "sensory perception, sensory detection of thermal stimulus" EXACT []
synonym: "sensory perception, sensory transduction of heat stimulus" NARROW []
synonym: "sensory perception, sensory transduction of temperature stimulus" EXACT []
synonym: "sensory perception, sensory transduction of thermal stimulus" EXACT []
synonym: "sensory transduction of heat stimulus during sensory perception" NARROW []
synonym: "sensory transduction of temperature stimulus" EXACT []
synonym: "sensory transduction of temperature stimulus during sensory perception" EXACT []
synonym: "sensory transduction of thermal stimulus during sensory perception" EXACT []
is_a: GO:0016048 ! detection of temperature stimulus
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
relationship: part_of GO:0050951 ! sensory perception of temperature stimulus

[Term]
id: GO:0050962
name: detection of light stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a sensory light stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "sensory detection of light stimulus" EXACT []
synonym: "sensory detection of light stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of light stimulus" EXACT []
synonym: "sensory perception, sensory transduction of light stimulus" EXACT []
synonym: "sensory transduction of light stimulus" EXACT []
synonym: "sensory transduction of light stimulus during sensory perception" EXACT []
is_a: GO:0009583 ! detection of light stimulus
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
relationship: part_of GO:0050953 ! sensory perception of light stimulus

[Term]
id: GO:0050963
name: detection of electrical stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a sensory electrical stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "sensory detection of electrical stimulus" EXACT []
synonym: "sensory detection of electrical stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of electrical stimulus" EXACT []
synonym: "sensory perception, sensory transduction of electrical stimulus" EXACT []
synonym: "sensory transduction of electrical stimulus" EXACT []
synonym: "sensory transduction of electrical stimulus during sensory perception" EXACT []
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
is_a: GO:0050981 ! detection of electrical stimulus
relationship: part_of GO:0050952 ! sensory perception of electrical stimulus

[Term]
id: GO:0050964
name: detection of electrical stimulus during electroception
namespace: biological_process
def: "The series of events during electroception in which a sensory electrical stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "electroception, detection of electrical stimulus" EXACT []
synonym: "electroception, sensory detection of electrical stimulus" EXACT []
synonym: "electroception, sensory transduction" EXACT []
synonym: "electroception, sensory transduction of electrical stimulus" EXACT []
synonym: "sensory detection of electrical stimulus during electroception" EXACT []
synonym: "sensory transduction of electrical stimulus during electroception" EXACT []
is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception
relationship: part_of GO:0050956 ! electroception

[Term]
id: GO:0050965
name: detection of temperature stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events involved in the perception of pain in which a sensory temperature stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "perception of pain, detection of temperature stimulus" EXACT []
synonym: "perception of pain, sensory detection of temperature stimulus" EXACT []
synonym: "perception of pain, sensory transduction of temperature stimulus" EXACT []
synonym: "sensory detection of temperature stimulus during perception of pain" EXACT []
synonym: "sensory detection of thermal stimulus during sensory perception of pain" EXACT []
synonym: "sensory perception of pain, sensory detection of thermal stimulus" EXACT []
synonym: "sensory perception of pain, sensory transduction of thermal stimulus" EXACT []
synonym: "sensory transduction of temperature stimulus during perception of pain" EXACT []
synonym: "sensory transduction of thermal stimulus during sensory perception of pain" EXACT []
is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception
relationship: part_of GO:0019233 ! sensory perception of pain

[Term]
id: GO:0050966
name: detection of mechanical stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events involved in the perception of pain in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "perception of pain, detection of mechanical stimulus" EXACT []
synonym: "perception of pain, sensory detection of mechanical stimulus" EXACT []
synonym: "perception of pain, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during perception of pain" EXACT []
synonym: "sensory transduction of mechanical stimulus during perception of pain" EXACT []
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: part_of GO:0019233 ! sensory perception of pain

[Term]
id: GO:0050967
name: detection of electrical stimulus during sensory perception of pain
namespace: biological_process
def: "The series of events during the perception of pain in which a sensory electrical stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "perception of pain, detection of electrical stimulus" EXACT []
synonym: "perception of pain, sensory detection of electrical stimulus" EXACT []
synonym: "perception of pain, sensory transduction of electrical stimulus" EXACT []
synonym: "sensory detection of electrical stimulus during perception of pain" EXACT []
synonym: "sensory transduction of electrical stimulus during perception of pain" EXACT []
is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception
relationship: part_of GO:0019233 ! sensory perception of pain

[Term]
id: GO:0050968
name: detection of chemical stimulus involved in sensory perception of pain
namespace: biological_process
def: "The series of events involved in the perception of pain in which a sensory chemical stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "perception of pain, detection of chemical stimulus" EXACT []
synonym: "perception of pain, sensory detection of chemical stimulus" EXACT []
synonym: "perception of pain, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during perception of pain" EXACT []
synonym: "sensory transduction of chemical stimulus during perception of pain" EXACT []
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
relationship: part_of GO:0019233 ! sensory perception of pain

[Term]
id: GO:0050969
name: detection of chemical stimulus involved in magnetoreception
namespace: biological_process
def: "The series of events involved in magnetoception in which a sensory chemical stimulus is received by a cell and converted into a molecular signal. It is believed that organisms such as birds and salamanders interpret product ratios in chemical reactions which involve transitions between different spin states." [GOC:ai]
synonym: "magnetoception, sensory transduction of chemical stimulus" EXACT []
synonym: "magnetoreception, detection of chemical stimulus" EXACT []
synonym: "magnetoreception, sensory detection of chemical stimulus" EXACT []
synonym: "magnetoreception, sensory transduction of chemical stimulus" EXACT []
synonym: "sensory detection of chemical stimulus during magnetoreception" EXACT []
synonym: "sensory transduction of chemical stimulus during magnetoreception" EXACT []
is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception
relationship: part_of GO:0050977 ! magnetoreception, using chemical stimulus

[Term]
id: GO:0050970
name: detection of electrical stimulus during magnetoreception
namespace: biological_process
def: "The series of events during magnetoception in which a sensory electrical stimulus is received by a cell and converted into a molecular signal. The stimulus is in the form of an induced electric field resulting from movement in a magnetic field." [GOC:ai, http://www.wikipedia.org/Magnetoception]
synonym: "magnetoception, sensory transduction of electrical stimulus" EXACT []
synonym: "magnetoreception, detection of electrical stimulus" EXACT []
synonym: "magnetoreception, sensory detection of electrical stimulus" EXACT []
synonym: "magnetoreception, sensory transduction of electrical stimulus" EXACT []
synonym: "sensory detection of electrical stimulus during magnetoreception" EXACT []
synonym: "sensory transduction of electrical stimulus during magnetoreception" EXACT []
is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception
relationship: part_of GO:0050978 ! magnetoreception, using electrical stimulus

[Term]
id: GO:0050971
name: detection of mechanical stimulus involved in magnetoreception
namespace: biological_process
def: "The series of events involved in magnetoception in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. The stimulus is in the form of torque on particles such as magnetite which respond to a magnetic field." [GOC:ai]
synonym: "magnetoception, sensory transduction of mechanical stimulus" EXACT []
synonym: "magnetoreception, detection of mechanical stimulus" EXACT []
synonym: "magnetoreception, sensory detection of mechanical stimulus" EXACT []
synonym: "magnetoreception, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during magnetoreception" EXACT []
synonym: "sensory transduction of mechanical stimulus during magnetoreception" EXACT []
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: part_of GO:0050979 ! magnetoreception, using mechanical stimulus

[Term]
id: GO:0050972
name: detection of mechanical stimulus involved in echolocation
namespace: biological_process
def: "The series of events involved in echolocation in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. The stimulus is in the form of a reflected sound wave (an echo), which the organism uses to determine the distance to the object that reflected the sound wave." [GOC:ai]
synonym: "echolocation, detection of mechanical stimulus" EXACT []
synonym: "echolocation, sensory detection of mechanical stimulus" EXACT []
synonym: "echolocation, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during echolocation" EXACT []
synonym: "sensory transduction of mechanical stimulus during echolocation" EXACT []
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: part_of GO:0050959 ! echolocation

[Term]
id: GO:0050973
name: detection of mechanical stimulus involved in equilibrioception
namespace: biological_process
def: "The series of events involved in equilibrioception in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears." [GOC:ai]
synonym: "equilibrioception, detection of mechanical stimulus" EXACT []
synonym: "equilibrioception, sensory detection of mechanical stimulus" EXACT []
synonym: "equilibrioception, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during equilibrioception" EXACT []
synonym: "sensory transduction of mechanical stimulus during equilibrioception" EXACT []
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: part_of GO:0050957 ! equilibrioception

[Term]
id: GO:0050974
name: detection of mechanical stimulus involved in sensory perception
namespace: biological_process
def: "The series of events in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "sensory detection of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during sensory perception" EXACT []
synonym: "sensory perception, sensory detection of mechanical stimulus" EXACT []
synonym: "sensory perception, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory transduction of mechanical stimulus during sensory perception" EXACT []
is_a: GO:0050906 ! detection of stimulus involved in sensory perception
is_a: GO:0050982 ! detection of mechanical stimulus
relationship: part_of GO:0050954 ! sensory perception of mechanical stimulus

[Term]
id: GO:0050975
name: sensory perception of touch
namespace: biological_process
def: "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai]
synonym: "perception of touch" EXACT []
synonym: "tactile sense" EXACT []
synonym: "taction" EXACT []
synonym: "tactition" EXACT []
xref: Wikipedia:Touch
is_a: GO:0050954 ! sensory perception of mechanical stimulus

[Term]
id: GO:0050976
name: detection of mechanical stimulus involved in sensory perception of touch
namespace: biological_process
def: "The series of events involved in the perception of touch in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "perception of touch, detection of mechanical stimulus" EXACT []
synonym: "perception of touch, sensory detection of mechanical stimulus" EXACT []
synonym: "perception of touch, sensory transduction of mechanical stimulus" EXACT []
synonym: "sensory detection of mechanical stimulus during perception of touch" EXACT []
synonym: "sensory transduction of mechanical stimulus during perception of touch" EXACT []
synonym: "tactition, sensory detection of mechanical stimulus" EXACT []
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: part_of GO:0050975 ! sensory perception of touch

[Term]
id: GO:0050977
name: magnetoreception, using chemical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a chemical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. It is believed that organisms such as birds and salamanders use a 'chemical compass': chemical reactions that involve transitions between different spin states can be influenced by magnetic fields and by detecting the different product ratios, these organisms can perceive the direction of the magnetic field. The mechanism by which this is detected is not certain but it may also involve light stimuli." [GOC:ai, http://www.wikipedia.org/Magnetoception]
synonym: "magnetoreception by chemical stimulus" EXACT []
synonym: "magnetoreception through chemical stimulus" EXACT []
synonym: "magnetoreception, sensory perception of chemical stimulus" EXACT []
is_a: GO:0007606 ! sensory perception of chemical stimulus
is_a: GO:0050958 ! magnetoreception

[Term]
id: GO:0050978
name: magnetoreception, using electrical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive an electrical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Movement in a magnetic field results in an induced electric field, which can be perceived by organisms such as elasmobranch fish." [GOC:ai, http://www.wikipedia.org/Magnetoception]
synonym: "magnetoreception by electrical stimulus" EXACT []
synonym: "magnetoreception through electrical stimulus" EXACT []
synonym: "magnetoreception, sensory perception of electrical stimulus" EXACT []
is_a: GO:0050952 ! sensory perception of electrical stimulus
is_a: GO:0050958 ! magnetoreception

[Term]
id: GO:0050979
name: magnetoreception, using mechanical stimulus
namespace: biological_process
def: "The series of events required for an organism to receive a mechanical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. A magnetic field exerts a torque on a ferromagnetic material (e.g. magnetite) or on a material with diamagnetic anisotropy; organisms that can detect this torque can use it to determine the orientation of the magnetic field." [GOC:ai, http://www.wikipedia.org/Magnetoception]
synonym: "magnetoreception by sensory perception of mechanical stimulus" EXACT []
synonym: "magnetoreception through mechanical stimulus" EXACT []
synonym: "magnetoreception, sensory perception of mechanical stimulus" EXACT []
is_a: GO:0050954 ! sensory perception of mechanical stimulus
is_a: GO:0050958 ! magnetoreception

[Term]
id: GO:0050980
name: detection of light stimulus involved in magnetoreception
namespace: biological_process
def: "The series of events involved in magnetoception in which a light stimulus is received by a cell and converted into a molecular signal. Downstream processing of the light information in addition to other sensory data allows organisms to perceive the orientation of a magnetic field." [GOC:ai, http://www.wikipedia.org/Magnetoception]
synonym: "magnetoreception, detection of light stimulus" EXACT []
synonym: "magnetoreception, sensory detection of light stimulus" EXACT []
synonym: "magnetoreception, sensory transduction of light stimulus" EXACT []
synonym: "sensory detection of light stimulus during magnetoreception" EXACT []
synonym: "sensory transduction of light stimulus during magnetoreception" EXACT []
is_a: GO:0050962 ! detection of light stimulus involved in sensory perception
relationship: part_of GO:0050958 ! magnetoreception

[Term]
id: GO:0050981
name: detection of electrical stimulus
namespace: biological_process
def: "The series of events by which an electrical stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
is_a: GO:0009582 ! detection of abiotic stimulus
is_a: GO:0051602 ! response to electrical stimulus

[Term]
id: GO:0050982
name: detection of mechanical stimulus
namespace: biological_process
def: "The series of events by which a mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
is_a: GO:0009581 ! detection of external stimulus
is_a: GO:0009582 ! detection of abiotic stimulus
is_a: GO:0009612 ! response to mechanical stimulus

[Term]
id: GO:0050983
name: spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase
namespace: biological_process
def: "The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+." [MetaCyc:1.1.1.249-RXN]
comment: Note that this reaction is catalyzed by a single enzyme but since it has multiple steps, it appears in the process ontology.
subset: gosubset_prok
synonym: "(4-aminobutyl)lysine synthase activity" RELATED [EC:2.5.1.46]
synonym: "[eIF-5A]-deoxyhypusine synthase activity" RELATED [EC:2.5.1.46]
synonym: "spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase" EXACT []
synonym: "spermidine degradation to deoxyhypusine, using deoxyhypusine synthase" EXACT []
xref: EC:2.5.1.46
xref: MetaCyc:2.5.1.46-RXN
is_a: GO:0046203 ! spermidine catabolic process

[Term]
id: GO:0050984
name: peptidyl-serine sulfation
namespace: biological_process
def: "The posttranslational sulfation of peptidyl-serine to form peptidyl-O-sulfo-L-serine." [RESID:AA0361]
subset: gosubset_prok
xref: RESID:AA0361
is_a: GO:0006477 ! protein amino acid sulfation
is_a: GO:0018209 ! peptidyl-serine modification

[Term]
id: GO:0050985
name: peptidyl-threonine sulfation
namespace: biological_process
def: "The posttranslational sulfation of peptidyl-threonine to form peptidyl-O-sulfo-L-threonine." [RESID:AA0362]
subset: gosubset_prok
xref: RESID:AA0362
is_a: GO:0006477 ! protein amino acid sulfation
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0050986
name: isopeptide cross-linking via N-(L-isoglutamyl)-glycine
namespace: biological_process
def: "The formation of an isopeptide cross-link between peptidyl-glutamate and peptidyl-glycine to produce N-(L-isoglutamyl)-glycine, as found in the antibiotic microcin J25." [PMID:14531691, RESID:AA0360]
subset: gosubset_prok
xref: RESID:AA0360
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0018262 ! isopeptide cross-linking

[Term]
id: GO:0050987
name: enzyme active site formation via O-sulfo-L-serine
namespace: biological_process
def: "The transient sulfation of peptidyl-serine to form O-sulfo-L-serine." [RESID:AA0361]
subset: gosubset_prok
xref: RESID:AA0361
is_a: GO:0018307 ! enzyme active site formation
is_a: GO:0050984 ! peptidyl-serine sulfation

[Term]
id: GO:0050988
name: N-terminal peptidyl-methionine carboxylation
namespace: biological_process
def: "The carboxylation of the N-terminal methionine of proteins to form the derivative N-carboxy-L-methionine." [RESID:AA0363]
subset: gosubset_prok
xref: RESID:AA0363
is_a: GO:0018206 ! peptidyl-methionine modification
is_a: GO:0050989 ! N-terminal protein amino acid carboxylation

[Term]
id: GO:0050989
name: N-terminal protein amino acid carboxylation
namespace: biological_process
def: "The carboxylation of the N-terminal amino acid of proteins." [GOC:ai]
subset: gosubset_prok
is_a: GO:0018409 ! peptide or protein amino-terminal blocking

[Term]
id: GO:0050990
name: N-terminal protein amino acid carbamoylation
namespace: biological_process
def: "The carbamoylation of the N-terminal amino acid of proteins." [GOC:ai]
subset: gosubset_prok
synonym: "N-terminal protein amino acid carbamylation" EXACT []
is_a: GO:0018409 ! peptide or protein amino-terminal blocking

[Term]
id: GO:0050991
name: enzyme active site formation via O-sulfo-L-threonine
namespace: biological_process
def: "The transient sulfation of peptidyl-threonine to form O-sulfo-L-threonine." [RESID:AA0362]
subset: gosubset_prok
xref: RESID:AA0362
is_a: GO:0018307 ! enzyme active site formation
is_a: GO:0050985 ! peptidyl-threonine sulfation

[Term]
id: GO:0050992
name: dimethylallyl diphosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dimethylallyl diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "dimethylallyl diphosphate anabolism" EXACT []
synonym: "dimethylallyl diphosphate biosynthesis" EXACT []
synonym: "dimethylallyl diphosphate formation" EXACT []
synonym: "dimethylallyl diphosphate synthesis" EXACT []
synonym: "dimethylallyl pyrophosphate biosynthesis" EXACT []
synonym: "dimethylallyl pyrophosphate biosynthetic process" EXACT []
synonym: "DPP biosynthesis" EXACT []
synonym: "DPP biosynthetic process" EXACT []
is_a: GO:0008654 ! phospholipid biosynthetic process
is_a: GO:0016091 ! prenol biosynthetic process
is_a: GO:0050993 ! dimethylallyl diphosphate metabolic process

[Term]
id: GO:0050993
name: dimethylallyl diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dimethylallyl diphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "dimethylallyl diphosphate metabolism" EXACT []
synonym: "dimethylallyl pyrophosphate metabolic process" EXACT []
synonym: "dimethylallyl pyrophosphate metabolism" EXACT []
synonym: "DPP metabolic process" EXACT []
synonym: "DPP metabolism" EXACT []
is_a: GO:0006644 ! phospholipid metabolic process
is_a: GO:0016090 ! prenol metabolic process

[Term]
id: GO:0050994
name: regulation of lipid catabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
synonym: "regulation of lipid breakdown" EXACT []
synonym: "regulation of lipid catabolism" EXACT []
synonym: "regulation of lipid degradation" EXACT []
is_a: GO:0009894 ! regulation of catabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
relationship: regulates GO:0016042 ! lipid catabolic process

[Term]
id: GO:0050995
name: negative regulation of lipid catabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
synonym: "down regulation of lipid catabolic process" EXACT []
synonym: "down-regulation of lipid catabolic process" EXACT []
synonym: "downregulation of lipid catabolic process" EXACT []
synonym: "inhibition of lipid catabolic process" NARROW []
synonym: "negative regulation of lipid breakdown" EXACT []
synonym: "negative regulation of lipid catabolism" EXACT []
synonym: "negative regulation of lipid degradation" EXACT []
is_a: GO:0009895 ! negative regulation of catabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
relationship: negatively_regulates GO:0016042 ! lipid catabolic process

[Term]
id: GO:0050996
name: positive regulation of lipid catabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]
synonym: "activation of lipid catabolic process" NARROW []
synonym: "positive regulation of lipid breakdown" EXACT []
synonym: "positive regulation of lipid catabolism" EXACT []
synonym: "positive regulation of lipid degradation" EXACT []
synonym: "stimulation of lipid catabolic process" NARROW []
synonym: "up regulation of lipid catabolic process" EXACT []
synonym: "up-regulation of lipid catabolic process" EXACT []
synonym: "upregulation of lipid catabolic process" EXACT []
is_a: GO:0009896 ! positive regulation of catabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
relationship: positively_regulates GO:0016042 ! lipid catabolic process

[Term]
id: GO:0050997
name: quaternary ammonium group binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai]
subset: gosubset_prok
synonym: "quaternary amine binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0050998
name: nitric-oxide synthase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme nitric-oxide synthase." [GOC:ai]
synonym: "NOS binding" EXACT []
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0050999
name: regulation of nitric-oxide synthase activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme nitric-oxide synthase." [GOC:ai]
subset: gosubset_prok
synonym: "nitric-oxide synthase regulator" EXACT []
synonym: "NOS regulator" EXACT []
synonym: "regulation of NOS activity" EXACT []
is_a: GO:0032768 ! regulation of monooxygenase activity

[Term]
id: GO:0051000
name: positive regulation of nitric-oxide synthase activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme nitric-oxide synthase." [GOC:ai]
subset: gosubset_prok
synonym: "activation of nitric-oxide synthase activity" NARROW []
synonym: "nitric-oxide synthase activator" EXACT []
synonym: "NOS activator" EXACT []
synonym: "positive regulation of NOS activity" EXACT []
synonym: "stimulation of nitric-oxide synthase activity" NARROW []
synonym: "up regulation of nitric-oxide synthase activity" EXACT []
synonym: "up-regulation of nitric-oxide synthase activity" EXACT []
synonym: "upregulation of nitric-oxide synthase activity" EXACT []
is_a: GO:0032770 ! positive regulation of monooxygenase activity
is_a: GO:0050999 ! regulation of nitric-oxide synthase activity

[Term]
id: GO:0051001
name: negative regulation of nitric-oxide synthase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme nitric-oxide synthase." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of nitric-oxide synthase activity" EXACT []
synonym: "down-regulation of nitric-oxide synthase activity" EXACT []
synonym: "downregulation of nitric-oxide synthase activity" EXACT []
synonym: "inhibition of nitric-oxide synthase activity" NARROW []
synonym: "negative regulation of NOS activity" EXACT []
synonym: "nitric-oxide synthase inhibitor" NARROW []
synonym: "NOS inhibitor" NARROW []
is_a: GO:0032769 ! negative regulation of monooxygenase activity
is_a: GO:0050999 ! regulation of nitric-oxide synthase activity

[Term]
id: GO:0051002
name: ligase activity, forming nitrogen-metal bonds
namespace: molecular_function
def: "Catalysis of the ligation of two substances via a nitrogen-metal bond." [EC:6.6.-.-]
subset: gosubset_prok
xref: EC:6.6
is_a: GO:0016874 ! ligase activity

[Term]
id: GO:0051003
name: ligase activity, forming nitrogen-metal bonds, forming coordination complexes
namespace: molecular_function
def: "Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex." [EC:6.6.1.-]
subset: gosubset_prok
xref: EC:6.6.1
is_a: GO:0051002 ! ligase activity, forming nitrogen-metal bonds

[Term]
id: GO:0051004
name: regulation of lipoprotein lipase activity
namespace: biological_process
def: "Any process that modulates the activity of the enzyme lipoprotein lipase." [GOC:ai]
subset: gosubset_prok
is_a: GO:0060191 ! regulation of lipase activity

[Term]
id: GO:0051005
name: negative regulation of lipoprotein lipase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme lipoprotein lipase." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of lipoprotein lipase activity" EXACT []
synonym: "down-regulation of lipoprotein lipase activity" EXACT []
synonym: "downregulation of lipoprotein lipase activity" EXACT []
synonym: "inhibition of lipoprotein lipase activity" NARROW []
is_a: GO:0051004 ! regulation of lipoprotein lipase activity
is_a: GO:0060192 ! negative regulation of lipase activity

[Term]
id: GO:0051006
name: positive regulation of lipoprotein lipase activity
namespace: biological_process
def: "Any process that activates or increases the activity of the enzyme lipoprotein lipase." [GOC:ai]
subset: gosubset_prok
synonym: "activation of lipoprotein lipase activity" NARROW []
synonym: "stimulation of lipoprotein lipase activity" NARROW []
synonym: "up regulation of lipoprotein lipase activity" EXACT []
synonym: "up-regulation of lipoprotein lipase activity" EXACT []
synonym: "upregulation of lipoprotein lipase activity" EXACT []
is_a: GO:0051004 ! regulation of lipoprotein lipase activity
is_a: GO:0060193 ! positive regulation of lipase activity

[Term]
id: GO:0051007
name: squalene-hopene cyclase activity
namespace: molecular_function
def: "Catalysis of the reaction: squalene = hop-22(29)-ene." [EC:5.4.99.17]
subset: gosubset_prok
synonym: "squalene mutase (cyclizing)" EXACT [EC:5.4.99.17]
synonym: "squalene:hopene cyclase activity" EXACT [PMID:18033581]
xref: EC:5.4.99.17
xref: MetaCyc:5.4.99.17-RXN
is_a: GO:0016866 ! intramolecular transferase activity
is_a: GO:0034072 ! squalene cyclase activity

[Term]
id: GO:0051008
name: Hsp27 protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Hsp27 proteins, a lightweight heat shock protein." [GOC:ai]
is_a: GO:0031072 ! heat shock protein binding

[Term]
id: GO:0051009
name: O-acetylhomoserine sulfhydrylase activity
namespace: molecular_function
def: "Catalysis of the reaction: O-acetyl-L-homoserine + H2S = homocysteine + acetate." [MetaCyc:ACETYLHOMOSER-CYS-RXN]
xref: MetaCyc:ACETYLHOMOSER-CYS-RXN
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0051010
name: microtubule plus-end binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]
is_a: GO:0008017 ! microtubule binding

[Term]
id: GO:0051011
name: microtubule minus-end binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]
is_a: GO:0008017 ! microtubule binding

[Term]
id: GO:0051012
name: microtubule sliding
namespace: biological_process
def: "The movement of one microtubule along another microtubule." [PMID:14557818, PMID:14614826]
synonym: "microtubule translocation" EXACT []
is_a: GO:0007018 ! microtubule-based movement

[Term]
id: GO:0051013
name: microtubule severing
namespace: biological_process
def: "The process by which a microtubule is broken down into smaller segments." [GOC:ai, PMID:14657234]
synonym: "microtubule severing activity" RELATED []
is_a: GO:0007017 ! microtubule-based process

[Term]
id: GO:0051014
name: actin filament severing
namespace: biological_process
def: "The process by which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234]
synonym: "actin filament severing activity" RELATED []
synonym: "barbed-end actin capping/severing activity" RELATED []
synonym: "F-actin severing" EXACT []
is_a: GO:0030029 ! actin filament-based process

[Term]
id: GO:0051015
name: actin filament binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "actin cross-linking activity" RELATED []
synonym: "F-actin binding" EXACT []
is_a: GO:0003779 ! actin binding

[Term]
id: GO:0051016
name: barbed-end actin filament capping
namespace: biological_process
def: "The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]
synonym: "barbed-end actin capping activity" EXACT []
synonym: "barbed-end F-actin capping activity" EXACT []
synonym: "plus-end actin filament capping activity" EXACT []
synonym: "plus-end F-actin capping activity" EXACT []
is_a: GO:0051693 ! actin filament capping

[Term]
id: GO:0051017
name: actin filament bundle assembly
namespace: biological_process
alt_id: GO:0045011
def: "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]
synonym: "actin bundling activity" RELATED []
synonym: "actin cable assembly" RELATED [GOC:mah]
synonym: "actin cable formation" RELATED [GOC:mah]
is_a: GO:0007015 ! actin filament organization
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0051018
name: protein kinase A binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any subunit of protein kinase A." [GOC:ai]
comment: Note that this term is a direct child of 'protein binding ; GO:0005515' because it encompasses binding to either the catalytic or regulatory subunit of protein kinase A, and the latter does not have kinase activity.
synonym: "PKA binding" EXACT []
synonym: "protein kinase A anchoring activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051019
name: mitogen-activated protein kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase." [GOC:ai]
synonym: "MAP kinase binding" EXACT []
synonym: "MAP-kinase anchoring activity" RELATED []
synonym: "MAPK binding" EXACT []
is_a: GO:0019901 ! protein kinase binding

[Term]
id: GO:0051020
name: GTPase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0051021
name: GDP-dissociation inhibitor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a GDP-dissociation inhibitor protein." [GOC:ai]
synonym: "GDI binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051022
name: Rho GDP-dissociation inhibitor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Rho GDP-dissociation inhibitor protein." [GOC:ai]
synonym: "Rho GDI binding" EXACT []
is_a: GO:0051021 ! GDP-dissociation inhibitor binding

[Term]
id: GO:0051023
name: regulation of immunoglobulin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell or group of cells." [GOC:ai]
synonym: "regulation of antibody secretion" EXACT []
is_a: GO:0002637 ! regulation of immunoglobulin production
is_a: GO:0050708 ! regulation of protein secretion
relationship: regulates GO:0048305 ! immunoglobulin secretion

[Term]
id: GO:0051024
name: positive regulation of immunoglobulin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell or group of cells." [GOC:ai]
synonym: "activation of immunoglobulin secretion" NARROW []
synonym: "positive regulation of antibody secretion" EXACT []
synonym: "stimulation of immunoglobulin secretion" NARROW []
synonym: "up regulation of immunoglobulin secretion" EXACT []
synonym: "up-regulation of immunoglobulin secretion" EXACT []
synonym: "upregulation of immunoglobulin secretion" EXACT []
is_a: GO:0050714 ! positive regulation of protein secretion
is_a: GO:0051023 ! regulation of immunoglobulin secretion
relationship: positively_regulates GO:0048305 ! immunoglobulin secretion

[Term]
id: GO:0051025
name: negative regulation of immunoglobulin secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of immunoglobulins from a cell or group of cells." [GOC:ai]
synonym: "down regulation of immunoglobulin secretion" EXACT []
synonym: "down-regulation of immunoglobulin secretion" EXACT []
synonym: "downregulation of immunoglobulin secretion" EXACT []
synonym: "inhibition of immunoglobulin secretion" NARROW []
synonym: "negative regulation of antibody secretion" EXACT []
is_a: GO:0050709 ! negative regulation of protein secretion
is_a: GO:0051023 ! regulation of immunoglobulin secretion
relationship: negatively_regulates GO:0048305 ! immunoglobulin secretion

[Term]
id: GO:0051026
name: chiasma assembly
namespace: biological_process
def: "The cell cycle process whereby a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids." [http://www.onelook.com]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0007129 ! synapsis

[Term]
id: GO:0051027
name: DNA transport
namespace: biological_process
def: "The directed movement of RNA, deoxyribonucleic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0050657 ! nucleic acid transport

[Term]
id: GO:0051028
name: mRNA transport
namespace: biological_process
def: "The directed movement of mRNA, messenger ribonucleic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:0051029
name: rRNA transport
namespace: biological_process
def: "The directed movement of rRNA, ribosomal ribonucleic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:0051030
name: snRNA transport
namespace: biological_process
def: "The directed movement of snRNA, small nuclear ribonucleic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:0051031
name: tRNA transport
namespace: biological_process
def: "The directed movement of tRNA, transfer ribonucleic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0050658 ! RNA transport

[Term]
id: GO:0051032
name: nucleic acid transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information." [GOC:ai]
is_a: GO:0015932 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity

[Term]
id: GO:0051033
name: RNA transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0051032 ! nucleic acid transmembrane transporter activity

[Term]
id: GO:0051034
name: tRNA transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0051033 ! RNA transmembrane transporter activity

[Term]
id: GO:0051035
name: DNA transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other." [GOC:ai]
is_a: GO:0051032 ! nucleic acid transmembrane transporter activity

[Term]
id: GO:0051036
name: regulation of endosome size
namespace: biological_process
def: "Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis." [GOC:ai]
synonym: "endosome enlargement" RELATED []
is_a: GO:0032535 ! regulation of cellular component size

[Term]
id: GO:0051037
name: regulation of transcription, meiotic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription during meiosis." [GOC:go_curators]
synonym: "meiotic regulation of transcription" EXACT []
synonym: "regulation of transcription during meiosis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0006355 ! regulation of transcription, DNA-dependent

[Term]
id: GO:0051038
name: negative regulation of transcription, meiotic
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription during meiosis." [GOC:ai]
synonym: "down regulation of transcription, meiotic" EXACT []
synonym: "down-regulation of transcription, meiotic" EXACT []
synonym: "downregulation of transcription, meiotic" EXACT []
synonym: "inhibition of transcription, meiotic" NARROW []
synonym: "meiotic repression of transcription" EXACT []
synonym: "negative regulation of meiotic transcription" EXACT []
synonym: "negative regulation of transcription during meiosis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent
is_a: GO:0051037 ! regulation of transcription, meiotic

[Term]
id: GO:0051039
name: positive regulation of transcription, meiotic
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription during meiosis." [GOC:ai]
synonym: "activation of transcription, meiotic" NARROW []
synonym: "positive regulation of meiotic transcription" EXACT []
synonym: "positive regulation of transcription during meiosis" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of transcription, meiotic" NARROW []
synonym: "up regulation of transcription, meiotic" EXACT []
synonym: "up-regulation of transcription, meiotic" EXACT []
synonym: "upregulation of transcription, meiotic" EXACT []
is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent
is_a: GO:0051037 ! regulation of transcription, meiotic

[Term]
id: GO:0051040
name: regulation of calcium-independent cell-cell adhesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:ai]
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: regulates GO:0016338 ! calcium-independent cell-cell adhesion

[Term]
id: GO:0051041
name: positive regulation of calcium-independent cell-cell adhesion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of calcium-independent cell-cell adhesion." [GOC:ai]
synonym: "activation of calcium-independent cell-cell adhesion" NARROW []
synonym: "stimulation of calcium-independent cell-cell adhesion" NARROW []
synonym: "up regulation of calcium-independent cell-cell adhesion" EXACT []
synonym: "up-regulation of calcium-independent cell-cell adhesion" EXACT []
synonym: "upregulation of calcium-independent cell-cell adhesion" EXACT []
is_a: GO:0022409 ! positive regulation of cell-cell adhesion
is_a: GO:0051040 ! regulation of calcium-independent cell-cell adhesion
relationship: positively_regulates GO:0016338 ! calcium-independent cell-cell adhesion

[Term]
id: GO:0051042
name: negative regulation of calcium-independent cell-cell adhesion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium-independent cell-cell adhesion." [GOC:ai]
synonym: "down regulation of calcium-independent cell-cell adhesion" EXACT []
synonym: "down-regulation of calcium-independent cell-cell adhesion" EXACT []
synonym: "downregulation of calcium-independent cell-cell adhesion" EXACT []
synonym: "inhibition of calcium-independent cell-cell adhesion" NARROW []
is_a: GO:0022408 ! negative regulation of cell-cell adhesion
is_a: GO:0051040 ! regulation of calcium-independent cell-cell adhesion
relationship: negatively_regulates GO:0016338 ! calcium-independent cell-cell adhesion

[Term]
id: GO:0051043
name: regulation of membrane protein ectodomain proteolysis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:ai]
subset: gosubset_prok
is_a: GO:0030162 ! regulation of proteolysis
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0042176 ! regulation of protein catabolic process
relationship: regulates GO:0006509 ! membrane protein ectodomain proteolysis

[Term]
id: GO:0051044
name: positive regulation of membrane protein ectodomain proteolysis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis." [GOC:ai]
subset: gosubset_prok
synonym: "activation of membrane protein ectodomain proteolysis" NARROW []
synonym: "stimulation of membrane protein ectodomain proteolysis" NARROW []
synonym: "up regulation of membrane protein ectodomain proteolysis" EXACT []
synonym: "up-regulation of membrane protein ectodomain proteolysis" EXACT []
synonym: "upregulation of membrane protein ectodomain proteolysis" EXACT []
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0045732 ! positive regulation of protein catabolic process
is_a: GO:0045862 ! positive regulation of proteolysis
is_a: GO:0051043 ! regulation of membrane protein ectodomain proteolysis
relationship: positively_regulates GO:0006509 ! membrane protein ectodomain proteolysis

[Term]
id: GO:0051045
name: negative regulation of membrane protein ectodomain proteolysis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of membrane protein ectodomain proteolysis" EXACT []
synonym: "down-regulation of membrane protein ectodomain proteolysis" EXACT []
synonym: "downregulation of membrane protein ectodomain proteolysis" EXACT []
synonym: "inhibition of membrane protein ectodomain proteolysis" NARROW []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0042177 ! negative regulation of protein catabolic process
is_a: GO:0045861 ! negative regulation of proteolysis
is_a: GO:0051043 ! regulation of membrane protein ectodomain proteolysis
relationship: negatively_regulates GO:0006509 ! membrane protein ectodomain proteolysis

[Term]
id: GO:0051046
name: regulation of secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or group of cells." [GOC:ai]
subset: gosubset_prok
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0046903 ! secretion

[Term]
id: GO:0051047
name: positive regulation of secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or group of cells." [GOC:ai]
synonym: "activation of secretion" NARROW []
synonym: "stimulation of secretion" NARROW []
synonym: "up regulation of secretion" EXACT []
synonym: "up-regulation of secretion" EXACT []
synonym: "upregulation of secretion" EXACT []
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051050 ! positive regulation of transport
relationship: positively_regulates GO:0046903 ! secretion

[Term]
id: GO:0051048
name: negative regulation of secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of a substance from a cell or group of cells." [GOC:ai]
synonym: "down regulation of secretion" EXACT []
synonym: "down-regulation of secretion" EXACT []
synonym: "downregulation of secretion" EXACT []
synonym: "inhibition of secretion" NARROW []
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051051 ! negative regulation of transport
relationship: negatively_regulates GO:0046903 ! secretion

[Term]
id: GO:0051049
name: regulation of transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
is_a: GO:0032879 ! regulation of localization
relationship: regulates GO:0006810 ! transport

[Term]
id: GO:0051050
name: positive regulation of transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "activation of transport" NARROW []
synonym: "stimulation of transport" NARROW []
synonym: "up regulation of transport" EXACT []
synonym: "up-regulation of transport" EXACT []
synonym: "upregulation of transport" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051049 ! regulation of transport
relationship: positively_regulates GO:0006810 ! transport

[Term]
id: GO:0051051
name: negative regulation of transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of transport" EXACT []
synonym: "down-regulation of transport" EXACT []
synonym: "downregulation of transport" EXACT []
synonym: "inhibition of transport" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051049 ! regulation of transport
relationship: negatively_regulates GO:0006810 ! transport

[Term]
id: GO:0051052
name: regulation of DNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of DNA metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0006259 ! DNA metabolic process

[Term]
id: GO:0051053
name: negative regulation of DNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of DNA metabolic process" EXACT []
synonym: "down-regulation of DNA metabolic process" EXACT []
synonym: "downregulation of DNA metabolic process" EXACT []
synonym: "inhibition of DNA metabolic process" NARROW []
synonym: "negative regulation of DNA metabolism" EXACT []
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: negatively_regulates GO:0006259 ! DNA metabolic process

[Term]
id: GO:0051054
name: positive regulation of DNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]
subset: gosubset_prok
synonym: "activation of DNA metabolic process" NARROW []
synonym: "positive regulation of DNA metabolism" EXACT []
synonym: "stimulation of DNA metabolic process" NARROW []
synonym: "up regulation of DNA metabolic process" EXACT []
synonym: "up-regulation of DNA metabolic process" EXACT []
synonym: "upregulation of DNA metabolic process" EXACT []
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: positively_regulates GO:0006259 ! DNA metabolic process

[Term]
id: GO:0051055
name: negative regulation of lipid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of lipid biosynthetic process" EXACT []
synonym: "down-regulation of lipid biosynthetic process" EXACT []
synonym: "downregulation of lipid biosynthetic process" EXACT []
synonym: "inhibition of lipid biosynthetic process" NARROW []
synonym: "negative regulation of lipid anabolism" EXACT []
synonym: "negative regulation of lipid biosynthesis" EXACT []
synonym: "negative regulation of lipid formation" EXACT []
synonym: "negative regulation of lipid synthesis" EXACT []
synonym: "negative regulation of lipogenesis" EXACT [GOC:sl]
is_a: GO:0009890 ! negative regulation of biosynthetic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: negatively_regulates GO:0008610 ! lipid biosynthetic process

[Term]
id: GO:0051056
name: regulation of small GTPase mediated signal transduction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]
synonym: "regulation of small GTPase-mediated signal transduction" EXACT []
xref: Reactome:194840 "Rho GTPase cycle"
xref: Reactome:449053 "Rho GTPase cycle"
xref: Reactome:470167 "Rho GTPase cycle"
xref: Reactome:487857 "Rho GTPase cycle"
xref: Reactome:507828 "Rho GTPase cycle"
xref: Reactome:517734 "Rho GTPase cycle"
xref: Reactome:526572 "Rho GTPase cycle"
xref: Reactome:531375 "Rho GTPase cycle"
xref: Reactome:536750 "Rho GTPase cycle"
xref: Reactome:542500 "Rho GTPase cycle"
xref: Reactome:547827 "Rho GTPase cycle"
xref: Reactome:552395 "Rho GTPase cycle"
xref: Reactome:558003 "Rho GTPase cycle"
xref: Reactome:568652 "Rho GTPase cycle"
xref: Reactome:581856 "Rho GTPase cycle"
xref: Reactome:585922 "Rho GTPase cycle"
xref: Reactome:592762 "Rho GTPase cycle"
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0007264 ! small GTPase mediated signal transduction

[Term]
id: GO:0051057
name: positive regulation of small GTPase mediated signal transduction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:ai]
synonym: "activation of small GTPase mediated signal transduction" NARROW []
synonym: "positive regulation of small GTPase-mediated signal transduction" EXACT []
synonym: "stimulation of small GTPase mediated signal transduction" NARROW []
synonym: "up regulation of small GTPase mediated signal transduction" EXACT []
synonym: "up-regulation of small GTPase mediated signal transduction" EXACT []
synonym: "upregulation of small GTPase mediated signal transduction" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
relationship: positively_regulates GO:0007264 ! small GTPase mediated signal transduction

[Term]
id: GO:0051058
name: negative regulation of small GTPase mediated signal transduction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:ai]
synonym: "down regulation of small GTPase mediated signal transduction" EXACT []
synonym: "down-regulation of small GTPase mediated signal transduction" EXACT []
synonym: "downregulation of small GTPase mediated signal transduction" EXACT []
synonym: "inhibition of small GTPase mediated signal transduction" NARROW []
synonym: "negative regulation of small GTPase-mediated signal transduction" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction
relationship: negatively_regulates GO:0007264 ! small GTPase mediated signal transduction

[Term]
id: GO:0051059
name: NF-kappaB binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai]
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0051060
name: pullulanase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of (1,6)-a-D-glucosidic linkages in pullulan [a linear polymer of a-(1,6)-linked maltotriose units] and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen." [EC:3.2.1.41]
subset: gosubset_prok
synonym: "alpha-dextrin endo-1,6-alpha-glucosidase activity" EXACT []
synonym: "amylopectin 6-glucanohydrolase activity" EXACT []
synonym: "bacterial debranching enzyme" RELATED [EC:3.2.1.41]
synonym: "debranching enzyme activity" BROAD [EC:3.2.1.41]
synonym: "limit dextrinase (erroneous)" BROAD [EC:3.2.1.41]
synonym: "pullulan 6-glucanohydrolase activity" EXACT []
synonym: "pullulan alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.41]
synonym: "R-enzyme" RELATED [EC:3.2.1.41]
xref: EC:3.2.1.41
xref: MetaCyc:RXN-1824
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0051061
name: ADP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin." [MetaCyc:ADPREDUCT-RXN]
synonym: "ADP reduction" RELATED []
xref: MetaCyc:ADPREDUCT-RXN
is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity

[Term]
id: GO:0051062
name: UDP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin." [MetaCyc:UDPREDUCT-RXN]
synonym: "UDP reduction" RELATED []
xref: MetaCyc:UDPREDUCT-RXN
is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity

[Term]
id: GO:0051063
name: CDP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin." [MetaCyc:CDPREDUCT-RXN]
synonym: "CDP reduction" RELATED []
xref: MetaCyc:CDPREDUCT-RXN
is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity

[Term]
id: GO:0051064
name: TTP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN]
synonym: "TTP reduction" RELATED []
xref: EC:1.17.4.-
is_a: GO:0008998 ! ribonucleoside-triphosphate reductase activity

[Term]
id: GO:0051065
name: CTP reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN]
synonym: "CTP reduction" RELATED []
xref: EC:1.17.4.-
is_a: GO:0008998 ! ribonucleoside-triphosphate reductase activity

[Term]
id: GO:0051066
name: dihydrobiopterin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dihydrobiopterin, a reduced pteridine derivative related to folic acid; it acts as an electron carrier in tyrosine biosynthesis and its quinoid form is produced by oxidation of tetrahydrobiopterin in several biological hydroxylation reactions." [http://www.onelook.com]
subset: gosubset_prok
synonym: "dihydrobiopterin metabolism" EXACT []
synonym: "dihydrobiopterin reduction" NARROW []
is_a: GO:0042558 ! pteridine and derivative metabolic process

[Term]
id: GO:0051067
name: dihydropteridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dihydropteridine, a bicyclic compound with the formula C6H6N4." [GOC:ai]
subset: gosubset_prok
synonym: "dihydropteridine metabolism" EXACT []
synonym: "dihydropteridine reduction" NARROW []
is_a: GO:0042558 ! pteridine and derivative metabolic process

[Term]
id: GO:0051068
name: dihydrolipoamide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dihydrolipoamide, the reduced form of lipoamide, produced as an intermediate in the reactions in which lipoamide acts as a cofactor." [ISBN:0721601464]
subset: gosubset_prok
synonym: "dihydrolipoamide metabolism" EXACT []
synonym: "dihydrolipoamide reduction" NARROW []
synonym: "dihydrothioctamide metabolic process" EXACT []
synonym: "dihydrothioctamide metabolism" EXACT []
is_a: GO:0043603 ! cellular amide metabolic process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0051069
name: galactomannan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving galactomannan, a polysaccharide composed of D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-galactose as single side units." [http://www.els.net/els/public/glossary/]
subset: gosubset_prok
synonym: "galactomannan metabolism" EXACT []
is_a: GO:0006080 ! substituted mannan metabolic process

[Term]
id: GO:0051070
name: galactomannan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units." [GOC:ai]
subset: gosubset_prok
synonym: "galactomannan anabolism" EXACT []
synonym: "galactomannan biosynthesis" EXACT []
synonym: "galactomannan formation" EXACT []
synonym: "galactomannan synthesis" EXACT []
is_a: GO:0046354 ! mannan biosynthetic process
is_a: GO:0051069 ! galactomannan metabolic process

[Term]
id: GO:0051071
name: 4,6-pyruvylated galactose residue metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:ai, PMID:15173185]
subset: gosubset_prok
synonym: "4,6-pyruvylated galactose residue metabolism" EXACT []
synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolic process" EXACT []
synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolism" EXACT []
synonym: "PvGal metabolic process" EXACT []
synonym: "PvGal metabolism" EXACT []
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0051072
name: 4,6-pyruvylated galactose residue biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:ai, PMID:15173185]
subset: gosubset_prok
synonym: "4,6-pyruvylated galactose residue anabolism" EXACT []
synonym: "4,6-pyruvylated galactose residue biosynthesis" EXACT []
synonym: "4,6-pyruvylated galactose residue formation" EXACT []
synonym: "4,6-pyruvylated galactose residue synthesis" EXACT []
synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthesis" EXACT []
synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthetic process" EXACT []
synonym: "PvGal biosynthesis" EXACT []
synonym: "PvGal biosynthetic process" EXACT []
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0051071 ! 4,6-pyruvylated galactose residue metabolic process

[Term]
id: GO:0051073
name: adenosylcobinamide-GDP ribazoletransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin." [EC:2.7.8.26, MetaCyc:COBALAMINSYN-RXN]
synonym: "adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase activity" EXACT [EC:2.7.8.26]
synonym: "cobalamin (5'-phosphate) synthase activity" EXACT [EC:2.7.8.26]
synonym: "cobalamin synthase activity" EXACT []
synonym: "cobalamin-5'-phosphate synthase activity" EXACT [EC:2.7.8.26]
synonym: "CobS" RELATED [EC:2.7.8.26]
xref: EC:2.7.8.26
xref: MetaCyc:COBALAMINSYN-RXN
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0051074
name: protein tetramerization activity
namespace: molecular_function
def: "OBSOLETE. The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]
comment: This term was made obsolete because it represents a process.
is_obsolete: true
replaced_by: GO:0051262

[Term]
id: GO:0051075
name: S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA [preQ1-tRNA] = adenine + methionine + epoxyqueuosine-tRNA [oQ-tRNA]." [PMID:12731872]
subset: gosubset_prok
synonym: "S-adenosyl methionine:tRNA ribosyltransferase-isomerase activity" EXACT []
is_a: GO:0016740 ! transferase activity
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0051076
name: Gram-positive bacterial binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of a Gram-positive bacterial cell." [GOC:ai]
subset: gosubset_prok
synonym: "binding to Gram-positive bacterium" EXACT []
synonym: "Gram-positive bacterium binding" EXACT []
is_a: GO:0008367 ! bacterial binding

[Term]
id: GO:0051077
name: secondary cell septum
namespace: cellular_component
def: "Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum." [GOC:mtg_sensu, PMID:15194814]
synonym: "secondary septum" BROAD []
is_a: GO:0030428 ! cell septum

[Term]
id: GO:0051078
name: meiotic nuclear envelope disassembly
namespace: biological_process
def: "The cell cycle process whereby the controlled breakdown of the nuclear envelope during meiotic cell division occurs." [GOC:bf]
synonym: "meiotic nuclear envelope breakdown" EXACT []
synonym: "meiotic nuclear envelope catabolism" EXACT []
synonym: "meiotic nuclear envelope degradation" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051081 ! nuclear envelope disassembly
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051079
name: meiosis I nuclear envelope disassembly
namespace: biological_process
def: "The controlled breakdown of the nuclear envelope during the first division of meiosis." [GOC:bf]
synonym: "meiosis I nuclear envelope breakdown" EXACT []
synonym: "meiosis I nuclear envelope catabolism" EXACT []
synonym: "meiosis I nuclear envelope degradation" EXACT []
is_a: GO:0051078 ! meiotic nuclear envelope disassembly
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0051080
name: meiosis II nuclear envelope disassembly
namespace: biological_process
def: "The controlled breakdown of the nuclear envelope during the second division of meiosis." [GOC:bf]
synonym: "meiosis II nuclear envelope breakdown" EXACT []
synonym: "meiosis II nuclear envelope catabolism" EXACT []
synonym: "meiosis II nuclear envelope degradation" EXACT []
is_a: GO:0051078 ! meiotic nuclear envelope disassembly
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0051081
name: nuclear envelope disassembly
namespace: biological_process
def: "The controlled breakdown of the nuclear envelope in the context of a normal process." [GOC:ai]
synonym: "nuclear envelope breakdown" EXACT []
synonym: "nuclear envelope catabolism" EXACT []
synonym: "nuclear envelope degradation" EXACT []
is_a: GO:0006998 ! nuclear envelope organization
is_a: GO:0030397 ! membrane disassembly

[Term]
id: GO:0051082
name: unfolded protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an unfolded protein." [GOC:ai]
subset: gosubset_prok
synonym: "binding unfolded ER proteins" NARROW []
synonym: "chaperone activity" RELATED []
synonym: "fimbrium-specific chaperone activity" RELATED []
synonym: "glycoprotein-specific chaperone activity" RELATED []
synonym: "histone-specific chaperone activity" RELATED []
synonym: "ribosomal chaperone activity" RELATED []
synonym: "tubulin-specific chaperone activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051083
name: 'de novo' cotranslational protein folding
namespace: biological_process
alt_id: GO:0006444
def: "The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated." [GOC:rb]
subset: gosubset_prok
synonym: "'de novo' co-translational protein folding" EXACT []
synonym: "multidomain protein assembly" EXACT []
synonym: "nascent polypeptide association" EXACT []
is_a: GO:0006458 ! 'de novo' protein folding

[Term]
id: GO:0051084
name: 'de novo' posttranslational protein folding
namespace: biological_process
def: "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb]
subset: gosubset_prok
synonym: "'de novo' post-translational protein folding" EXACT []
xref: Reactome:391251 "Protein folding"
xref: Reactome:448641 "Protein folding"
xref: Reactome:469769 "Protein folding"
xref: Reactome:487590 "Protein folding"
xref: Reactome:507423 "Protein folding"
xref: Reactome:517426 "Protein folding"
xref: Reactome:526300 "Protein folding"
xref: Reactome:531208 "Protein folding"
xref: Reactome:536536 "Protein folding"
xref: Reactome:542257 "Protein folding"
xref: Reactome:547601 "Protein folding"
xref: Reactome:552208 "Protein folding"
xref: Reactome:557799 "Protein folding"
xref: Reactome:568412 "Protein folding"
xref: Reactome:581614 "Protein folding"
xref: Reactome:585815 "Protein folding"
xref: Reactome:592511 "Protein folding"
xref: Reactome:595350 "Protein folding"
is_a: GO:0006458 ! 'de novo' protein folding

[Term]
id: GO:0051085
name: chaperone mediated protein folding requiring cofactor
namespace: biological_process
def: "The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb]
subset: gosubset_prok
synonym: "chaperone co-factor-dependent protein folding" EXACT []
synonym: "chaperone cofactor-dependent 'de novo' protein folding" EXACT [GOC:mah]
synonym: "chaperone cofactor-dependent protein folding" EXACT [GOC:rb]
is_a: GO:0051084 ! 'de novo' posttranslational protein folding

[Term]
id: GO:0051086
name: chaperone mediated protein folding independent of cofactor
namespace: biological_process
def: "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb]
subset: gosubset_prok
synonym: "chaperone cofactor-independent protein folding" EXACT [GOC:rb]
xref: Reactome:390450 "Folding of actin by CCT/TriC"
xref: Reactome:392030 "Folding of actin by CCT/TriC"
xref: Reactome:449084 "Folding of actin by CCT/TriC"
xref: Reactome:470196 "Folding of actin by CCT/TriC"
xref: Reactome:487881 "Folding of actin by CCT/TriC"
xref: Reactome:507854 "Folding of actin by CCT/TriC"
xref: Reactome:517758 "Folding of actin by CCT/TriC"
xref: Reactome:526593 "Folding of actin by CCT/TriC"
xref: Reactome:531389 "Folding of actin by CCT/TriC"
xref: Reactome:536763 "Folding of actin by CCT/TriC"
xref: Reactome:542518 "Folding of actin by CCT/TriC"
xref: Reactome:547841 "Folding of actin by CCT/TriC"
xref: Reactome:552413 "Folding of actin by CCT/TriC"
xref: Reactome:558022 "Folding of actin by CCT/TriC"
xref: Reactome:568672 "Folding of actin by CCT/TriC"
xref: Reactome:581875 "Folding of actin by CCT/TriC"
xref: Reactome:585928 "Folding of actin by CCT/TriC"
xref: Reactome:592779 "Folding of actin by CCT/TriC"
xref: Reactome:595504 "Folding of actin by CCT/TriC"
is_a: GO:0051084 ! 'de novo' posttranslational protein folding

[Term]
id: GO:0051087
name: chaperone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [http://www.onelook.com]
subset: gosubset_prok
synonym: "chaperone protein binding" EXACT []
synonym: "co-chaperone activity" RELATED []
synonym: "co-chaperonin activity" RELATED []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051088
name: PMA-inducible membrane protein ectodomain proteolysis
namespace: biological_process
def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist." [PMID:12714508]
is_a: GO:0006509 ! membrane protein ectodomain proteolysis

[Term]
id: GO:0051089
name: constitutive protein ectodomain proteolysis
namespace: biological_process
def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands." [PMID:12714508]
subset: gosubset_prok
is_a: GO:0006509 ! membrane protein ectodomain proteolysis

[Term]
id: GO:0051090
name: regulation of transcription factor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]
subset: gosubset_prok
is_a: GO:0045449 ! regulation of transcription
is_a: GO:0051101 ! regulation of DNA binding
is_a: GO:0090046 ! regulation of transcription regulator activity

[Term]
id: GO:0051091
name: positive regulation of transcription factor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]
subset: gosubset_prok
synonym: "activation of transcription factor activity" NARROW []
synonym: "stimulation of transcription factor activity" NARROW []
synonym: "up regulation of transcription factor activity" EXACT []
synonym: "up-regulation of transcription factor activity" EXACT []
synonym: "upregulation of transcription factor activity" EXACT []
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:0051090 ! regulation of transcription factor activity
is_a: GO:0090047 ! positive regulation of transcription regulator activity

[Term]
id: GO:0051092
name: positive regulation of NF-kappaB transcription factor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]
synonym: "activation of NF-kappaB" EXACT []
synonym: "activation of NF-kappaB transcription factor" EXACT [GOC:dph, GOC:tb]
synonym: "NF-kappaB activation" EXACT []
is_a: GO:0051091 ! positive regulation of transcription factor activity

[Term]
id: GO:0051093
name: negative regulation of developmental process
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of developmental process" EXACT []
synonym: "down-regulation of developmental process" EXACT []
synonym: "downregulation of developmental process" EXACT []
synonym: "inhibition of developmental process" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0050793 ! regulation of developmental process
relationship: negatively_regulates GO:0032502 ! developmental process

[Term]
id: GO:0051094
name: positive regulation of developmental process
namespace: biological_process
def: "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]
subset: gosubset_prok
synonym: "activation of developmental process" NARROW []
synonym: "stimulation of developmental process" NARROW []
synonym: "up regulation of developmental process" EXACT []
synonym: "up-regulation of developmental process" EXACT []
synonym: "upregulation of developmental process" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0050793 ! regulation of developmental process
relationship: positively_regulates GO:0032502 ! developmental process

[Term]
id: GO:0051095
name: regulation of helicase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of helicase activity." [GOC:ai]
subset: gosubset_prok
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0051096
name: positive regulation of helicase activity
namespace: biological_process
def: "Any process that activates or increases the activity of a helicase." [GOC:ai]
subset: gosubset_prok
synonym: "activation of helicase activity" NARROW []
synonym: "stimulation of helicase activity" NARROW []
synonym: "up regulation of helicase activity" EXACT []
synonym: "up-regulation of helicase activity" EXACT []
synonym: "upregulation of helicase activity" EXACT []
is_a: GO:0051095 ! regulation of helicase activity
is_a: GO:0051345 ! positive regulation of hydrolase activity

[Term]
id: GO:0051097
name: negative regulation of helicase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of a helicase." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of helicase activity" EXACT []
synonym: "down-regulation of helicase activity" EXACT []
synonym: "downregulation of helicase activity" EXACT []
synonym: "inhibition of helicase activity" NARROW []
is_a: GO:0051095 ! regulation of helicase activity
is_a: GO:0051346 ! negative regulation of hydrolase activity

[Term]
id: GO:0051098
name: regulation of binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]
subset: gosubset_prok
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0051099
name: positive regulation of binding
namespace: biological_process
def: "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]
subset: gosubset_prok
synonym: "activation of binding" NARROW []
synonym: "stimulation of binding" NARROW []
synonym: "up regulation of binding" EXACT []
synonym: "up-regulation of binding" EXACT []
synonym: "upregulation of binding" EXACT []
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:0051100
name: negative regulation of binding
namespace: biological_process
def: "Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of binding" EXACT []
synonym: "down-regulation of binding" EXACT []
synonym: "downregulation of binding" EXACT []
synonym: "inhibition of binding" NARROW []
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:0051101
name: regulation of DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
is_a: GO:0051098 ! regulation of binding

[Term]
id: GO:0051102
name: DNA ligation during DNA recombination
namespace: biological_process
def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, as occurs during DNA recombination." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006266 ! DNA ligation
relationship: part_of GO:0006310 ! DNA recombination

[Term]
id: GO:0051103
name: DNA ligation during DNA repair
namespace: biological_process
def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, as occurs during DNA repair." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006266 ! DNA ligation
relationship: part_of GO:0006281 ! DNA repair

[Term]
id: GO:0051104
name: DNA ligation during DNA-dependent DNA replication
namespace: biological_process
def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, as occurs during DNA-dependent DNA replication." [GOC:ai]
subset: gosubset_prok
is_a: GO:0006266 ! DNA ligation
relationship: part_of GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0051105
name: regulation of DNA ligation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai]
subset: gosubset_prok
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0006266 ! DNA ligation

[Term]
id: GO:0051106
name: positive regulation of DNA ligation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai]
subset: gosubset_prok
synonym: "activation of DNA ligation" NARROW []
synonym: "stimulation of DNA ligation" NARROW []
synonym: "up regulation of DNA ligation" EXACT []
synonym: "up-regulation of DNA ligation" EXACT []
synonym: "upregulation of DNA ligation" EXACT []
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:0051105 ! regulation of DNA ligation
relationship: positively_regulates GO:0006266 ! DNA ligation

[Term]
id: GO:0051107
name: negative regulation of DNA ligation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of DNA ligation" EXACT []
synonym: "down-regulation of DNA ligation" EXACT []
synonym: "downregulation of DNA ligation" EXACT []
synonym: "inhibition of DNA ligation" NARROW []
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:0051105 ! regulation of DNA ligation
relationship: negatively_regulates GO:0006266 ! DNA ligation

[Term]
id: GO:0051108
name: carnitine-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA." [MetaCyc:DCARNCOALIG-RXN]
synonym: "carnitine synthetase activity" EXACT []
synonym: "crotonobetaine/carnitine-CoA ligase activity" BROAD []
xref: MetaCyc:DCARNCOALIG-RXN
is_a: GO:0016405 ! CoA-ligase activity
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0051109
name: crotonobetaine-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA." [MetaCyc:CROTCOALIG-RXN]
synonym: "crotonobetaine-CoA synthase activity" EXACT []
synonym: "crotonobetaine/carnitine-CoA ligase activity" BROAD []
xref: MetaCyc:CROTCOALIG-RXN
is_a: GO:0016405 ! CoA-ligase activity

[Term]
id: GO:0051110
name: peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine
namespace: biological_process
def: "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine)." [RESID:AA0372]
subset: gosubset_prok
xref: RESID:AA0372
is_a: GO:0051114 ! peptidyl-histidine uridylylation

[Term]
id: GO:0051111
name: peptidyl-histidine adenylylation
namespace: biological_process
def: "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine) or peptidyl-3'-(phospho-5'-adenosine)-L-histidine (otherwise known as pi-AMP-histidine, pros-AMP-histidine)." [RESID:AA0371]
subset: gosubset_prok
xref: RESID:AA0371
is_a: GO:0018117 ! protein amino acid adenylylation
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0051112
name: peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine
namespace: biological_process
def: "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine)." [RESID:AA0371]
subset: gosubset_prok
xref: RESID:AA0371
is_a: GO:0051111 ! peptidyl-histidine adenylylation

[Term]
id: GO:0051113
name: enzyme active site formation via 1'-(phospho-5'-adenosine)-L-histidine
namespace: biological_process
def: "The transient adenylylation of peptidyl-histidine to form 1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine)." [RESID:AA0371]
subset: gosubset_prok
xref: RESID:AA0371
is_a: GO:0018307 ! enzyme active site formation
is_a: GO:0051112 ! peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine

[Term]
id: GO:0051114
name: peptidyl-histidine uridylylation
namespace: biological_process
def: "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine) or peptidyl-3'-(phospho-5'-uridine)-L-histidine (otherwise known as pi-UMP-histidine, pros-UMP-histidine)." [RESID:AA0372]
subset: gosubset_prok
xref: RESID:AA0372
is_a: GO:0018177 ! protein amino acid uridylylation
is_a: GO:0018202 ! peptidyl-histidine modification

[Term]
id: GO:0051115
name: enzyme active site formation via 1'-(phospho-5'-uridine)-L-histidine
namespace: biological_process
def: "The transient uridylylation of peptidyl-histidine to form 1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine)." [RESID:AA0372]
subset: gosubset_prok
xref: RESID:AA0372
is_a: GO:0018307 ! enzyme active site formation
is_a: GO:0051110 ! peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine

[Term]
id: GO:0051116
name: cobaltochelatase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + hydrogenobyrinic acid a,c-diamide + Co2+ = ADP + phosphate + cob(II)yrinic acid a,c-diamide + H+." [EC:6.6.1.2]
subset: gosubset_prok
synonym: "CobN-CobST" RELATED [EC:6.6.1.2]
synonym: "CobNST" NARROW []
synonym: "hydrogenobyrinic acid a,c-diamide cobaltochelatase activity" EXACT []
synonym: "hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming)" EXACT [EC:6.6.1.2]
xref: EC:6.6.1.2
xref: MetaCyc:R342-RXN
is_a: GO:0051003 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes

[Term]
id: GO:0051117
name: ATPase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP." [GOC:ai]
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0051118
name: glucan endo-1,3-alpha-glucosidase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 1,3-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran." [EC:3.2.1.59]
synonym: "1,3(1,3;1,4)-alpha-D-glucan 3-glucanohydrolase activity" EXACT [EC:3.2.1.59]
synonym: "cariogenanase activity" EXACT [EC:3.2.1.59]
synonym: "cariogenase activity" EXACT [EC:3.2.1.59]
synonym: "endo-(1->3)-alpha-glucanase activity" EXACT [EC:3.2.1.59]
synonym: "endo-1,3-alpha-D-glucanase activity" EXACT [EC:3.2.1.59]
synonym: "endo-1,3-alpha-glucanase activity" EXACT [EC:3.2.1.59]
synonym: "mutanase activity" EXACT [EC:3.2.1.59]
xref: EC:3.2.1.59
xref: MetaCyc:3.2.1.59-RXN
is_a: GO:0015926 ! glucosidase activity

[Term]
id: GO:0051119
name: sugar transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a sugar from one side of the membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
subset: gosubset_prok
synonym: "sugar/polyol channel activity" NARROW []
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity

[Term]
id: GO:0051120
name: hepoxilin A3 synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid [12S-HpETE] = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate [hepoxilin A3]." [PMID:15123652]
is_a: GO:0016853 ! isomerase activity

[Term]
id: GO:0051121
name: hepoxilin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." [PMID:15123652]
subset: gosubset_prok
synonym: "hepoxilin metabolism" EXACT []
is_a: GO:0006690 ! icosanoid metabolic process

[Term]
id: GO:0051122
name: hepoxilin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." [GOC:ai]
subset: gosubset_prok
synonym: "hepoxilin anabolism" EXACT []
synonym: "hepoxilin biosynthesis" EXACT []
synonym: "hepoxilin formation" EXACT []
synonym: "hepoxilin synthesis" EXACT []
is_a: GO:0046456 ! icosanoid biosynthetic process
is_a: GO:0051121 ! hepoxilin metabolic process

[Term]
id: GO:0051123
name: RNA polymerase II transcriptional preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from the RNA polymerase II promoter." [PMID:10882737]
synonym: "RNA polymerase II transcription PIC biosynthesis" EXACT []
synonym: "RNA polymerase II transcription PIC formation" EXACT []
synonym: "RNA polymerase II transcriptional preinitiation complex formation" EXACT []
is_a: GO:0070897 ! transcriptional preinitiation complex assembly
relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter

[Term]
id: GO:0051124
name: synaptic growth at neuromuscular junction
namespace: biological_process
def: "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "cholinergic synaptogenesis" RELATED []
is_a: GO:0007416 ! synapse assembly
is_a: GO:0007528 ! neuromuscular junction development
is_a: GO:0048589 ! developmental growth

[Term]
id: GO:0051125
name: regulation of actin nucleation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai]
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
relationship: regulates GO:0045010 ! actin nucleation

[Term]
id: GO:0051126
name: negative regulation of actin nucleation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai]
synonym: "down regulation of actin nucleation" EXACT []
synonym: "down-regulation of actin nucleation" EXACT []
synonym: "downregulation of actin nucleation" EXACT []
synonym: "inhibition of actin nucleation" NARROW []
is_a: GO:0051125 ! regulation of actin nucleation
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
relationship: negatively_regulates GO:0045010 ! actin nucleation

[Term]
id: GO:0051127
name: positive regulation of actin nucleation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai]
synonym: "activation of actin nucleation" NARROW []
synonym: "stimulation of actin nucleation" NARROW []
synonym: "up regulation of actin nucleation" EXACT []
synonym: "up-regulation of actin nucleation" EXACT []
synonym: "upregulation of actin nucleation" EXACT []
is_a: GO:0051125 ! regulation of actin nucleation
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
relationship: positively_regulates GO:0045010 ! actin nucleation

[Term]
id: GO:0051128
name: regulation of cellular component organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of cell organisation" RELATED [GOC:mah]
synonym: "regulation of cell organization" RELATED [GOC:mah]
synonym: "regulation of cellular component organisation" EXACT [GOC:curators]
synonym: "regulation of cellular component organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0016043 ! cellular component organization

[Term]
id: GO:0051129
name: negative regulation of cellular component organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of cell organization" EXACT []
synonym: "down-regulation of cell organization" EXACT []
synonym: "downregulation of cell organization" EXACT []
synonym: "inhibition of cell organization" NARROW []
synonym: "negative regulation of cell organisation" RELATED [GOC:mah]
synonym: "negative regulation of cellular component organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: negatively_regulates GO:0016043 ! cellular component organization

[Term]
id: GO:0051130
name: positive regulation of cellular component organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]
synonym: "activation of cell organization" NARROW []
synonym: "positive regulation of cell organisation" EXACT []
synonym: "positive regulation of cellular component organization and biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cell organization" NARROW []
synonym: "up regulation of cell organization" EXACT []
synonym: "up-regulation of cell organization" EXACT []
synonym: "upregulation of cell organization" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: positively_regulates GO:0016043 ! cellular component organization

[Term]
id: GO:0051131
name: chaperone-mediated protein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai]
subset: gosubset_prok
synonym: "chaperone activity" RELATED []
synonym: "protein complex assembly, multichaperone pathway" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0051132
name: NK T cell activation
namespace: biological_process
def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426]
comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repetoire of variable region gene segments.
synonym: "natural killer T cell activation" EXACT []
synonym: "natural T cell activation" EXACT []
synonym: "NK T lymphocyte activation" EXACT []
synonym: "NK T-cell activation" EXACT []
synonym: "NK T-lymphocyte activation" EXACT []
synonym: "NKT cell activation" EXACT []
synonym: "NT cell activation" EXACT []
is_a: GO:0046631 ! alpha-beta T cell activation

[Term]
id: GO:0051133
name: regulation of NK T cell activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426]
synonym: "regulation of natural killer T cell activation" EXACT []
synonym: "regulation of natural T cell activation" EXACT []
synonym: "regulation of NK T lymphocyte activation" EXACT []
synonym: "regulation of NK T-cell activation" EXACT []
synonym: "regulation of NK T-lymphocyte activation" EXACT []
synonym: "regulation of NKT cell activation" EXACT []
synonym: "regulation of NT cell activation" EXACT []
is_a: GO:0046634 ! regulation of alpha-beta T cell activation
relationship: regulates GO:0051132 ! NK T cell activation

[Term]
id: GO:0051134
name: negative regulation of NK T cell activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426]
synonym: "down regulation of NK T cell activation" EXACT []
synonym: "down-regulation of NK T cell activation" EXACT []
synonym: "downregulation of NK T cell activation" EXACT []
synonym: "inhibition of NK T cell activation" NARROW []
synonym: "negative regulation of natural killer T cell activation" EXACT []
synonym: "negative regulation of natural T cell activation" EXACT []
synonym: "negative regulation of NK T lymphocyte activation" EXACT []
synonym: "negative regulation of NK T-cell activation" EXACT []
synonym: "negative regulation of NK T-lymphocyte activation" EXACT []
synonym: "negative regulation of NKT cell activation" EXACT []
synonym: "negative regulation of NT cell activation" EXACT []
is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation
is_a: GO:0051133 ! regulation of NK T cell activation
relationship: negatively_regulates GO:0051132 ! NK T cell activation

[Term]
id: GO:0051135
name: positive regulation of NK T cell activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426]
synonym: "activation of NK T cell activation" NARROW []
synonym: "positive regulation of natural killer T cell activation" EXACT []
synonym: "positive regulation of natural T cell activation" EXACT []
synonym: "positive regulation of NK T lymphocyte activation" EXACT []
synonym: "positive regulation of NK T-cell activation" EXACT []
synonym: "positive regulation of NK T-lymphocyte activation" EXACT []
synonym: "positive regulation of NKT cell activation" EXACT []
synonym: "positive regulation of NT cell activation" EXACT []
synonym: "stimulation of NK T cell activation" NARROW []
synonym: "up regulation of NK T cell activation" EXACT []
synonym: "up-regulation of NK T cell activation" EXACT []
synonym: "upregulation of NK T cell activation" EXACT []
is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation
is_a: GO:0051133 ! regulation of NK T cell activation
relationship: positively_regulates GO:0051132 ! NK T cell activation

[Term]
id: GO:0051136
name: regulation of NK T cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426]
synonym: "regulation of natural killer T cell differentiation" EXACT []
synonym: "regulation of natural T cell differentiation" EXACT []
synonym: "regulation of NK T lymphocyte differentiation" EXACT []
synonym: "regulation of NK T-cell differentiation" EXACT []
synonym: "regulation of NK T-lymphocyte differentiation" EXACT []
synonym: "regulation of NKT cell differentiation" EXACT []
synonym: "regulation of NT cell differentiation" EXACT []
is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation
relationship: regulates GO:0001865 ! NK T cell differentiation

[Term]
id: GO:0051137
name: negative regulation of NK T cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426]
synonym: "down regulation of NK T cell differentiation" EXACT []
synonym: "down-regulation of NK T cell differentiation" EXACT []
synonym: "downregulation of NK T cell differentiation" EXACT []
synonym: "inhibition of NK T cell differentiation" NARROW []
synonym: "negative regulation of natural killer T cell differentiation" EXACT []
synonym: "negative regulation of natural T cell differentiation" EXACT []
synonym: "negative regulation of NK T lymphocyte differentiation" EXACT []
synonym: "negative regulation of NK T-cell differentiation" EXACT []
synonym: "negative regulation of NK T-lymphocyte differentiation" EXACT []
synonym: "negative regulation of NKT cell differentiation" EXACT []
synonym: "negative regulation of NT cell differentiation" EXACT []
is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation
is_a: GO:0051136 ! regulation of NK T cell differentiation
relationship: negatively_regulates GO:0001865 ! NK T cell differentiation

[Term]
id: GO:0051138
name: positive regulation of NK T cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426]
synonym: "activation of NK T cell differentiation" NARROW []
synonym: "positive regulation of natural killer T cell differentiation" EXACT []
synonym: "positive regulation of natural T cell differentiation" EXACT []
synonym: "positive regulation of NK T lymphocyte differentiation" EXACT []
synonym: "positive regulation of NK T-cell differentiation" EXACT []
synonym: "positive regulation of NK T-lymphocyte differentiation" EXACT []
synonym: "positive regulation of NKT cell differentiation" EXACT []
synonym: "positive regulation of NT cell differentiation" EXACT []
synonym: "stimulation of NK T cell differentiation" NARROW []
synonym: "up regulation of NK T cell differentiation" EXACT []
synonym: "up-regulation of NK T cell differentiation" EXACT []
synonym: "upregulation of NK T cell differentiation" EXACT []
is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation
is_a: GO:0051136 ! regulation of NK T cell differentiation
relationship: positively_regulates GO:0001865 ! NK T cell differentiation

[Term]
id: GO:0051139
name: metal ion:hydrogen antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in)." [GOC:mlg]
subset: gosubset_prok
synonym: "metal ion:proton antiporter activity" EXACT []
is_a: GO:0015299 ! solute:hydrogen antiporter activity
is_a: GO:0015491 ! cation:cation antiporter activity

[Term]
id: GO:0051140
name: regulation of NK T cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426]
synonym: "regulation of natural killer T cell proliferation" EXACT []
synonym: "regulation of natural T cell proliferation" EXACT []
synonym: "regulation of NK T lymphocyte proliferation" EXACT []
synonym: "regulation of NK T-cell proliferation" EXACT []
synonym: "regulation of NK T-lymphocyte proliferation" EXACT []
synonym: "regulation of NKT cell proliferation" EXACT []
synonym: "regulation of NT cell proliferation" EXACT []
is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation
relationship: regulates GO:0001866 ! NK T cell proliferation

[Term]
id: GO:0051141
name: negative regulation of NK T cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426]
synonym: "down regulation of NK T cell proliferation" EXACT []
synonym: "down-regulation of NK T cell proliferation" EXACT []
synonym: "downregulation of NK T cell proliferation" EXACT []
synonym: "inhibition of NK T cell proliferation" NARROW []
synonym: "negative regulation of natural killer T cell proliferation" EXACT []
synonym: "negative regulation of natural T cell proliferation" EXACT []
synonym: "negative regulation of NK T lymphocyte proliferation" EXACT []
synonym: "negative regulation of NK T-cell proliferation" EXACT []
synonym: "negative regulation of NK T-lymphocyte proliferation" EXACT []
synonym: "negative regulation of NKT cell proliferation" EXACT []
synonym: "negative regulation of NT cell proliferation" EXACT []
is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation
is_a: GO:0051140 ! regulation of NK T cell proliferation
relationship: negatively_regulates GO:0001866 ! NK T cell proliferation

[Term]
id: GO:0051142
name: positive regulation of NK T cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149 "Fundamental Immunology", PMID:12154375, PMID:9133426]
synonym: "activation of NK T cell proliferation" NARROW []
synonym: "positive regulation of natural killer T cell proliferation" EXACT []
synonym: "positive regulation of natural T cell proliferation" EXACT []
synonym: "positive regulation of NK T lymphocyte proliferation" EXACT []
synonym: "positive regulation of NK T-cell proliferation" EXACT []
synonym: "positive regulation of NK T-lymphocyte proliferation" EXACT []
synonym: "positive regulation of NKT cell proliferation" EXACT []
synonym: "positive regulation of NT cell proliferation" EXACT []
synonym: "stimulation of NK T cell proliferation" NARROW []
synonym: "up regulation of NK T cell proliferation" EXACT []
synonym: "up-regulation of NK T cell proliferation" EXACT []
synonym: "upregulation of NK T cell proliferation" EXACT []
is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation
is_a: GO:0051140 ! regulation of NK T cell proliferation
relationship: positively_regulates GO:0001866 ! NK T cell proliferation

[Term]
id: GO:0051143
name: propanediol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving propanediol, CH3-CHOH-CH2OH, a sweet, colorless, viscous, hygroscopic liquid used as an antifreeze, in brake fluid and as a humectant in cosmetics and personal care items." [http://www.onelook.com]
subset: gosubset_prok
synonym: "1,2-dihydroxypropane metabolic process" EXACT []
synonym: "1,2-dihydroxypropane metabolism" EXACT []
synonym: "propanediol metabolism" EXACT []
synonym: "propylene glycol metabolic process" EXACT []
synonym: "propylene glycol metabolism" EXACT []
is_a: GO:0034311 ! diol metabolic process

[Term]
id: GO:0051144
name: propanediol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH." [GOC:ai]
subset: gosubset_prok
synonym: "1,2-dihydroxypropane catabolic process" EXACT []
synonym: "1,2-dihydroxypropane catabolism" EXACT []
synonym: "propanediol breakdown" EXACT []
synonym: "propanediol catabolism" EXACT []
synonym: "propanediol degradation" EXACT []
synonym: "propylene glycol catabolic process" EXACT []
synonym: "propylene glycol catabolism" EXACT []
is_a: GO:0034313 ! diol catabolic process
is_a: GO:0051143 ! propanediol metabolic process

[Term]
id: GO:0051145
name: smooth muscle cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai]
synonym: "nonstriated muscle cell differentiation" EXACT []
is_a: GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051146
name: striated muscle cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle." [CL:0000737, GOC:ai]
synonym: "voluntary muscle cell differentiation" NARROW []
is_a: GO:0042692 ! muscle cell differentiation
relationship: part_of GO:0014706 ! striated muscle tissue development

[Term]
id: GO:0051147
name: regulation of muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051148
name: negative regulation of muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]
synonym: "down regulation of muscle cell differentiation" EXACT []
synonym: "down-regulation of muscle cell differentiation" EXACT []
synonym: "downregulation of muscle cell differentiation" EXACT []
synonym: "inhibition of muscle cell differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0051147 ! regulation of muscle cell differentiation
relationship: negatively_regulates GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051149
name: positive regulation of muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]
synonym: "activation of muscle cell differentiation" NARROW []
synonym: "stimulation of muscle cell differentiation" NARROW []
synonym: "up regulation of muscle cell differentiation" EXACT []
synonym: "up-regulation of muscle cell differentiation" EXACT []
synonym: "upregulation of muscle cell differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0051147 ! regulation of muscle cell differentiation
relationship: positively_regulates GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0051150
name: regulation of smooth muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]
is_a: GO:0051147 ! regulation of muscle cell differentiation
relationship: regulates GO:0051145 ! smooth muscle cell differentiation

[Term]
id: GO:0051151
name: negative regulation of smooth muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]
synonym: "down regulation of smooth muscle cell differentiation" EXACT []
synonym: "down-regulation of smooth muscle cell differentiation" EXACT []
synonym: "downregulation of smooth muscle cell differentiation" EXACT []
synonym: "inhibition of smooth muscle cell differentiation" NARROW []
is_a: GO:0051148 ! negative regulation of muscle cell differentiation
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
relationship: negatively_regulates GO:0051145 ! smooth muscle cell differentiation

[Term]
id: GO:0051152
name: positive regulation of smooth muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]
synonym: "activation of smooth muscle cell differentiation" NARROW []
synonym: "stimulation of smooth muscle cell differentiation" NARROW []
synonym: "up regulation of smooth muscle cell differentiation" EXACT []
synonym: "up-regulation of smooth muscle cell differentiation" EXACT []
synonym: "upregulation of smooth muscle cell differentiation" EXACT []
is_a: GO:0051149 ! positive regulation of muscle cell differentiation
is_a: GO:0051150 ! regulation of smooth muscle cell differentiation
relationship: positively_regulates GO:0051145 ! smooth muscle cell differentiation

[Term]
id: GO:0051153
name: regulation of striated muscle cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]
is_a: GO:0016202 ! regulation of striated muscle tissue development
is_a: GO:0051147 ! regulation of muscle cell differentiation
relationship: regulates GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0051154
name: negative regulation of striated muscle cell differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]
synonym: "down regulation of striated muscle cell differentiation" EXACT []
synonym: "down-regulation of striated muscle cell differentiation" EXACT []
synonym: "downregulation of striated muscle cell differentiation" EXACT []
synonym: "inhibition of striated muscle cell differentiation" NARROW []
is_a: GO:0051148 ! negative regulation of muscle cell differentiation
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
relationship: negatively_regulates GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0051155
name: positive regulation of striated muscle cell differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]
synonym: "activation of striated muscle cell differentiation" NARROW []
synonym: "stimulation of striated muscle cell differentiation" NARROW []
synonym: "up regulation of striated muscle cell differentiation" EXACT []
synonym: "up-regulation of striated muscle cell differentiation" EXACT []
synonym: "upregulation of striated muscle cell differentiation" EXACT []
is_a: GO:0051149 ! positive regulation of muscle cell differentiation
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
relationship: positively_regulates GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0051156
name: glucose 6-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]
subset: gosubset_prok
synonym: "glucose 6-phosphate metabolism" EXACT []
xref: Reactome:170810 "nucleoplasmic GK:GKRP complex => glucokinase (GK) + glucokinase regulatory protein (GKRP)"
xref: Reactome:170822 "Negative Regulation of Glucokinase by Glucokinase Regulatory Protein"
xref: Reactome:170824 "glucokinase (GK) + glucokinase regulatory protein (GKRP) <=> GK:GKRP complex"
xref: Reactome:439879 "glucokinase (GK) + glucokinase regulatory protein (GKRP) <=> GK:GKRP complex"
xref: Reactome:443342 "nucleoplasmic GK:GKRP complex => glucokinase (GK) + glucokinase regulatory protein (GKRP)"
xref: Reactome:449004 "Negative Regulation of Glucokinase by Glucokinase Regulatory Protein"
xref: Reactome:470238 "Negative Regulation of Glucokinase by Glucokinase Regulatory Protein"
xref: Reactome:487921 "Negative Regulation of Glucokinase by Glucokinase Regulatory Protein"
xref: Reactome:500489 "glucokinase (GK) + glucokinase regulatory protein (GKRP) <=> GK:GKRP complex"
xref: Reactome:503585 "nucleoplasmic GK:GKRP complex => glucokinase (GK) + glucokinase regulatory protein (GKRP)"
xref: Reactome:507779 "Negative Regulation of Glucokinase by Glucokinase Regulatory Protein"
xref: Reactome:517784 "Negative Regulation of Glucokinase by Glucokinase Regulatory Protein"
xref: Reactome:529457 "glucokinase (GK) + glucokinase regulatory protein (GKRP) <=> GK:GKRP complex"
xref: Reactome:530074 "nucleoplasmic GK:GKRP complex => glucokinase (GK) + glucokinase regulatory protein (GKRP)"
xref: Reactome:531330 "Negative Regulation of Glucokinase by Glucokinase Regulatory Protein"
is_a: GO:0006006 ! glucose metabolic process

[Term]
id: GO:0051157
name: arabitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "arabitol breakdown" EXACT []
synonym: "arabitol catabolism" EXACT []
synonym: "arabitol degradation" EXACT []
is_a: GO:0019527 ! pentitol catabolic process
is_a: GO:0051161 ! arabitol metabolic process

[Term]
id: GO:0051158
name: L-arabitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "L-arabitol breakdown" EXACT []
synonym: "L-arabitol catabolism" EXACT []
synonym: "L-arabitol degradation" EXACT []
is_a: GO:0051157 ! arabitol catabolic process
is_a: GO:0051162 ! L-arabitol metabolic process

[Term]
id: GO:0051159
name: D-arabitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-arabitol breakdown" EXACT []
synonym: "D-arabitol catabolism" EXACT []
synonym: "D-arabitol degradation" EXACT []
is_a: GO:0051157 ! arabitol catabolic process
is_a: GO:0051163 ! D-arabitol metabolic process

[Term]
id: GO:0051160
name: L-xylitol catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group." [GOC:ai]
subset: gosubset_prok
synonym: "L-xylitol breakdown" EXACT []
synonym: "L-xylitol catabolism" EXACT []
synonym: "L-xylitol degradation" EXACT []
is_a: GO:0019527 ! pentitol catabolic process
is_a: GO:0051164 ! L-xylitol metabolic process

[Term]
id: GO:0051161
name: arabitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "arabitol metabolism" EXACT []
is_a: GO:0019519 ! pentitol metabolic process

[Term]
id: GO:0051162
name: L-arabitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "L-arabitol metabolism" EXACT []
is_a: GO:0051161 ! arabitol metabolic process

[Term]
id: GO:0051163
name: D-arabitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
synonym: "D-arabitol metabolism" EXACT []
is_a: GO:0051161 ! arabitol metabolic process

[Term]
id: GO:0051164
name: L-xylitol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets." [GOC:ai, http://www.onelook.com]
subset: gosubset_prok
synonym: "L-xylitol metabolism" EXACT []
is_a: GO:0019519 ! pentitol metabolic process

[Term]
id: GO:0051165
name: 2,5-dihydroxypyridine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 2,5-dihydroxypyridine." [GOC:ai]
subset: gosubset_prok
synonym: "2,5-dihydroxypyridine metabolism" EXACT []
is_a: GO:0019507 ! pyridine metabolic process

[Term]
id: GO:0051166
name: 2,5-dihydroxypyridine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine." [GOC:ai]
subset: gosubset_prok
synonym: "2,5-dihydroxypyridine breakdown" EXACT []
synonym: "2,5-dihydroxypyridine catabolism" EXACT []
synonym: "2,5-dihydroxypyridine degradation" EXACT []
is_a: GO:0046221 ! pyridine catabolic process
is_a: GO:0051165 ! 2,5-dihydroxypyridine metabolic process

[Term]
id: GO:0051167
name: xylulose 5-phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving xylulose 5-phosphate, a derivative of the ketopentose xylulose phosphorylated at the 5 carbon; it is an intermediate in the pentose phosphate pathway." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
subset: gosubset_prok
synonym: "D-xylulose 5-phosphate metabolic process" EXACT []
synonym: "D-xylulose 5-phosphate metabolism" EXACT []
synonym: "D-xylulose-5-phosphate metabolic process" EXACT []
synonym: "D-xylulose-5-phosphate metabolism" EXACT []
synonym: "xylulose 5-phosphate metabolism" EXACT []
synonym: "xylulose-5-phosphate metabolic process" EXACT []
synonym: "xylulose-5-phosphate metabolism" EXACT []
is_a: GO:0019321 ! pentose metabolic process
is_a: GO:0019637 ! organophosphate metabolic process

[Term]
id: GO:0051168
name: nuclear export
namespace: biological_process
def: "The directed movement of substances out of the nucleus." [GOC:ai]
synonym: "export from nucleus" EXACT []
synonym: "nucleus export" EXACT []
synonym: "substance nuclear export" EXACT []
xref: Reactome:191825 "Nuclear export of snRNA transcripts"
xref: Reactome:443331 "Nuclear export of snRNA transcripts"
xref: Reactome:464986 "Nuclear export of snRNA transcripts"
xref: Reactome:483345 "Nuclear export of snRNA transcripts"
xref: Reactome:515392 "Nuclear export of snRNA transcripts"
is_a: GO:0006913 ! nucleocytoplasmic transport

[Term]
id: GO:0051169
name: nuclear transport
namespace: biological_process
def: "The directed movement of substances into, out of, or within the nucleus." [GOC:ai]
synonym: "nucleus transport" EXACT []
xref: Reactome:162590 "Import of PIC to the Host Nucleus"
xref: Wikipedia:Nuclear_transport
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0051170
name: nuclear import
namespace: biological_process
def: "The directed movement of substances into the nucleus." [GOC:ai]
synonym: "import into nucleus" EXACT []
synonym: "nucleus import" EXACT []
synonym: "substance nuclear import" EXACT []
xref: Reactome:191830 "snRNP nuclear import and release"
xref: Reactome:446966 "snRNP nuclear import and release"
xref: Reactome:468240 "snRNP nuclear import and release"
is_a: GO:0006913 ! nucleocytoplasmic transport

[Term]
id: GO:0051171
name: regulation of nitrogen compound metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]
subset: gosubset_prok
synonym: "regulation of nitrogen metabolic process" EXACT [GOC:tb]
synonym: "regulation of nitrogen metabolism" EXACT []
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0051172
name: negative regulation of nitrogen compound metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]
synonym: "down regulation of nitrogen metabolic process" EXACT []
synonym: "down-regulation of nitrogen metabolic process" EXACT []
synonym: "downregulation of nitrogen metabolic process" EXACT []
synonym: "inhibition of nitrogen metabolic process" NARROW []
synonym: "negative regulation of nitrogen metabolic process" EXACT [GOC:tb]
synonym: "negative regulation of nitrogen metabolism" EXACT []
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
relationship: negatively_regulates GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0051173
name: positive regulation of nitrogen compound metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]
synonym: "activation of nitrogen metabolic process" NARROW []
synonym: "positive regulation of nitrogen metabolic process" EXACT [GOC:tb]
synonym: "positive regulation of nitrogen metabolism" EXACT []
synonym: "stimulation of nitrogen metabolic process" NARROW []
synonym: "up regulation of nitrogen metabolic process" EXACT []
synonym: "up-regulation of nitrogen metabolic process" EXACT []
synonym: "upregulation of nitrogen metabolic process" EXACT []
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
relationship: positively_regulates GO:0006807 ! nitrogen compound metabolic process

[Term]
id: GO:0051174
name: regulation of phosphorus metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of phosphorus metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
relationship: regulates GO:0006793 ! phosphorus metabolic process

[Term]
id: GO:0051175
name: negative regulation of sulfur metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of sulfur metabolic process" EXACT []
synonym: "down-regulation of sulfur metabolic process" EXACT []
synonym: "downregulation of sulfur metabolic process" EXACT []
synonym: "inhibition of sulfur metabolic process" NARROW []
synonym: "negative regulation of sulfur metabolism" EXACT []
synonym: "negative regulation of sulphur metabolic process" EXACT []
synonym: "negative regulation of sulphur metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
relationship: negatively_regulates GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0051176
name: positive regulation of sulfur metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai]
subset: gosubset_prok
synonym: "activation of sulfur metabolic process" NARROW []
synonym: "positive regulation of sulfur metabolism" EXACT []
synonym: "positive regulation of sulphur metabolic process" EXACT []
synonym: "positive regulation of sulphur metabolism" EXACT []
synonym: "stimulation of sulfur metabolic process" NARROW []
synonym: "up regulation of sulfur metabolic process" EXACT []
synonym: "up-regulation of sulfur metabolic process" EXACT []
synonym: "upregulation of sulfur metabolic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
relationship: positively_regulates GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0051177
name: meiotic sister chromatid cohesion
namespace: biological_process
def: "The cell cycle process whereby sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis." [GOC:ai]
is_a: GO:0007062 ! sister chromatid cohesion
relationship: part_of GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0051178
name: meiotic chromosome decondensation
namespace: biological_process
def: "The cell cycle process whereby chromosome structure is altered from the condensed form held during meiosis to the relaxed dispersed form held in resting cells." [GOC:ai]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051312 ! chromosome decondensation
relationship: part_of GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0051179
name: localization
namespace: biological_process
def: "Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "establishment and maintenance of cellular component location" NARROW []
synonym: "establishment and maintenance of localization" EXACT []
synonym: "establishment and maintenance of position" EXACT []
synonym: "establishment and maintenance of substance location" NARROW []
synonym: "establishment and maintenance of substrate location" NARROW []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0051180
name: vitamin transport
namespace: biological_process
def: "The directed movement of vitamins into, out of, within or between cells by means of some external agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "vitamin or cofactor transport" BROAD []
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0051181
name: cofactor transport
namespace: biological_process
def: "The directed movement of a cofactor into, out of, within or between cells by means of some external agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "vitamin or cofactor transport" BROAD []
is_a: GO:0006810 ! transport

[Term]
id: GO:0051182
name: coenzyme transport
namespace: biological_process
def: "The directed movement of a coenzyme into, out of, within or between cells by means of some external agent such as a transporter or pore. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
is_a: GO:0051181 ! cofactor transport

[Term]
id: GO:0051183
name: vitamin transporter activity
namespace: molecular_function
def: "Enables the directed movement of vitamins into, out of, within or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin or cofactor transporter activity" BROAD []
synonym: "vitamin transmembrane transporter activity" EXACT [GOC:mah]
is_a: GO:0022857 ! transmembrane transporter activity

[Term]
id: GO:0051184
name: cofactor transporter activity
namespace: molecular_function
def: "Enables the directed movement of a cofactor into, out of, within or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
subset: gosubset_prok
synonym: "vitamin or cofactor transporter activity" BROAD []
is_a: GO:0005215 ! transporter activity

[Term]
id: GO:0051185
name: coenzyme transporter activity
namespace: molecular_function
def: "Enables the directed movement of a coenzyme into, out of, within or between cells. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]
is_a: GO:0051184 ! cofactor transporter activity

[Term]
id: GO:0051186
name: cofactor metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai]
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "cofactor metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0051187
name: cofactor catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
subset: gosubset_prok
synonym: "cofactor breakdown" EXACT []
synonym: "cofactor catabolism" EXACT []
synonym: "cofactor degradation" EXACT []
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0051188
name: cofactor biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai]
subset: gosubset_prok
synonym: "cofactor anabolism" EXACT []
synonym: "cofactor biosynthesis" EXACT []
synonym: "cofactor formation" EXACT []
synonym: "cofactor synthesis" EXACT []
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0051189
name: prosthetic group metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "coenzyme and prosthetic group metabolic process" BROAD []
synonym: "coenzyme and prosthetic group metabolism" BROAD []
synonym: "prosthetic group metabolism" EXACT []
is_a: GO:0051186 ! cofactor metabolic process
relationship: part_of GO:0044267 ! cellular protein metabolic process

[Term]
id: GO:0051190
name: prosthetic group catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai]
subset: gosubset_prok
synonym: "coenzyme and prosthetic group catabolic process" BROAD []
synonym: "coenzyme and prosthetic group catabolism" BROAD []
synonym: "prosthetic group breakdown" EXACT []
synonym: "prosthetic group catabolism" EXACT []
synonym: "prosthetic group degradation" EXACT []
is_a: GO:0051187 ! cofactor catabolic process
is_a: GO:0051189 ! prosthetic group metabolic process
relationship: part_of GO:0044257 ! cellular protein catabolic process

[Term]
id: GO:0051191
name: prosthetic group biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai]
subset: gosubset_prok
synonym: "coenzyme and prosthetic group biosynthesis" BROAD []
synonym: "coenzyme and prosthetic group biosynthetic process" BROAD []
synonym: "prosthetic group anabolism" EXACT []
synonym: "prosthetic group biosynthesis" EXACT []
synonym: "prosthetic group formation" EXACT []
synonym: "prosthetic group synthesis" EXACT []
is_a: GO:0051188 ! cofactor biosynthetic process
is_a: GO:0051189 ! prosthetic group metabolic process
relationship: part_of GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0051192
name: prosthetic group binding
namespace: molecular_function
def: "The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules." [GOC:ai]
subset: gosubset_prok
is_a: GO:0048037 ! cofactor binding

[Term]
id: GO:0051193
name: regulation of cofactor metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of cofactor metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
relationship: regulates GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0051194
name: positive regulation of cofactor metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]
subset: gosubset_prok
synonym: "activation of cofactor metabolic process" NARROW []
synonym: "positive regulation of cofactor metabolism" EXACT []
synonym: "stimulation of cofactor metabolic process" NARROW []
synonym: "up regulation of cofactor metabolic process" EXACT []
synonym: "up-regulation of cofactor metabolic process" EXACT []
synonym: "upregulation of cofactor metabolic process" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0051193 ! regulation of cofactor metabolic process
relationship: positively_regulates GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0051195
name: negative regulation of cofactor metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of cofactor metabolic process" EXACT []
synonym: "down-regulation of cofactor metabolic process" EXACT []
synonym: "downregulation of cofactor metabolic process" EXACT []
synonym: "inhibition of cofactor metabolic process" NARROW []
synonym: "negative regulation of cofactor metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0051193 ! regulation of cofactor metabolic process
relationship: negatively_regulates GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0051196
name: regulation of coenzyme metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "regulation of coenzyme metabolism" EXACT []
is_a: GO:0051193 ! regulation of cofactor metabolic process
relationship: regulates GO:0006732 ! coenzyme metabolic process

[Term]
id: GO:0051197
name: positive regulation of coenzyme metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]
subset: gosubset_prok
synonym: "activation of coenzyme metabolic process" NARROW []
synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "positive regulation of coenzyme metabolism" EXACT []
synonym: "stimulation of coenzyme metabolic process" NARROW []
synonym: "up regulation of coenzyme metabolic process" EXACT []
synonym: "up-regulation of coenzyme metabolic process" EXACT []
synonym: "upregulation of coenzyme metabolic process" EXACT []
is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
relationship: positively_regulates GO:0006732 ! coenzyme metabolic process

[Term]
id: GO:0051198
name: negative regulation of coenzyme metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of coenzyme metabolic process" EXACT []
synonym: "down-regulation of coenzyme metabolic process" EXACT []
synonym: "downregulation of coenzyme metabolic process" EXACT []
synonym: "inhibition of coenzyme metabolic process" NARROW []
synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "negative regulation of coenzyme metabolism" EXACT []
is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
relationship: negatively_regulates GO:0006732 ! coenzyme metabolic process

[Term]
id: GO:0051199
name: regulation of prosthetic group metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "regulation of prosthetic group metabolism" EXACT []
is_a: GO:0032268 ! regulation of cellular protein metabolic process
is_a: GO:0051193 ! regulation of cofactor metabolic process
relationship: regulates GO:0051189 ! prosthetic group metabolic process

[Term]
id: GO:0051200
name: positive regulation of prosthetic group metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai]
subset: gosubset_prok
synonym: "activation of prosthetic group metabolic process" NARROW []
synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "positive regulation of prosthetic group metabolism" EXACT []
synonym: "stimulation of prosthetic group metabolic process" NARROW []
synonym: "up regulation of prosthetic group metabolic process" EXACT []
synonym: "up-regulation of prosthetic group metabolic process" EXACT []
synonym: "upregulation of prosthetic group metabolic process" EXACT []
is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:0051199 ! regulation of prosthetic group metabolic process
relationship: positively_regulates GO:0051189 ! prosthetic group metabolic process

[Term]
id: GO:0051201
name: negative regulation of prosthetic group metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of prosthetic group metabolic process" EXACT []
synonym: "down-regulation of prosthetic group metabolic process" EXACT []
synonym: "downregulation of prosthetic group metabolic process" EXACT []
synonym: "inhibition of prosthetic group metabolic process" NARROW []
synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD []
synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD []
synonym: "negative regulation of prosthetic group metabolism" EXACT []
is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:0051199 ! regulation of prosthetic group metabolic process
relationship: negatively_regulates GO:0051189 ! prosthetic group metabolic process

[Term]
id: GO:0051202
name: phytochromobilin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytochromobilin, the linear tetrapyrrole chromophore required for plant phytochrome photoactivity." [PMID:11500553]
subset: gosubset_prok
synonym: "phytochromobilin metabolism" EXACT []
is_a: GO:0033013 ! tetrapyrrole metabolic process
is_a: GO:0051186 ! cofactor metabolic process

[Term]
id: GO:0051203
name: peptidyl-aspartic acid reduction to form L-aspartyl aldehyde
namespace: biological_process
def: "The posttranslational reduction of peptidyl-aspartic acid to form peptidyl-L-aspartyl aldehyde, as found photosystem II P680 chlorophyll A apoprotein." [PMID:15237995, RESID:AA0373]
comment: See also UniProtKB:P04160.
subset: gosubset_prok
synonym: "peptidyl-aspartic acid reduction to form L-aspartate-beta-semialdehyde" EXACT []
synonym: "peptidyl-aspartic acid reduction to form L-beta-formylalanine" EXACT []
xref: RESID:AA0373
is_a: GO:0018197 ! peptidyl-aspartic acid modification

[Term]
id: GO:0051204
name: protein insertion into mitochondrial membrane
namespace: biological_process
def: "The process by which a protein is incorporated into a mitochondrial membrane." [GOC:ai]
synonym: "integral mitochondrial membrane protein localization" EXACT []
synonym: "integral mitochondrial membrane protein positioning" EXACT []
synonym: "localization of protein in mitochondrial membrane" EXACT []
synonym: "positioning of protein in mitochondrial membrane" EXACT []
synonym: "protein insertion into mitochondrion membrane" EXACT []
synonym: "protein-mitochondrial membrane insertion" EXACT []
synonym: "protein-mitochondrion membrane insertion" EXACT []
is_a: GO:0007006 ! mitochondrial membrane organization
is_a: GO:0051205 ! protein insertion into membrane

[Term]
id: GO:0051205
name: protein insertion into membrane
namespace: biological_process
def: "The process by which a protein is incorporated into a biological membrane." [GOC:ai]
subset: gosubset_prok
synonym: "integral membrane protein localization" EXACT []
synonym: "integral membrane protein positioning" EXACT []
synonym: "membrane protein localization" EXACT []
synonym: "membrane protein positioning" EXACT []
synonym: "protein-membrane insertion" EXACT []
is_a: GO:0034613 ! cellular protein localization
is_a: GO:0051668 ! localization within membrane
relationship: part_of GO:0016044 ! cellular membrane organization

[Term]
id: GO:0051206
name: silicate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving silicates, the salts of silicic acids. Silicates are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai]
subset: gosubset_prok
synonym: "silicate metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0051207
name: silicic acid transport
namespace: biological_process
def: "The directed movement of silicic acid into, out of, within or between cells by means of some external agent such as a transporter or pore. Silicic acid, Si(OH)4, is a hydrated form of silicon dioxide that occurs in nature; it is insoluble in water or acids except hydrofluoric acid." [GOC:ai, http://www.onelook.com]
is_a: GO:0006810 ! transport

[Term]
id: GO:0051208
name: sequestering of calcium ion
namespace: biological_process
def: "The process of binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]
synonym: "calcium ion (Ca2+) retention" EXACT []
synonym: "calcium ion (Ca2+) sequestering" EXACT []
synonym: "calcium ion (Ca2+) sequestration" EXACT []
synonym: "calcium ion (Ca2+) storage" EXACT []
synonym: "calcium ion storage activity" RELATED []
synonym: "negative regulation of calcium ion (Ca2+) transport" RELATED []
synonym: "retention of calcium ion (Ca2+)" EXACT []
synonym: "sequestering of calcium ion (Ca2+)" EXACT []
synonym: "sequestration of calcium ion (Ca2+)" EXACT []
synonym: "storage of calcium ion (Ca2+)" EXACT []
is_a: GO:0051238 ! sequestering of metal ion
relationship: part_of GO:0006874 ! cellular calcium ion homeostasis

[Term]
id: GO:0051209
name: release of sequestered calcium ion into cytosol
namespace: biological_process
def: "The process by which calcium ions sequestered in the endoplasmic reticulum or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung]
synonym: "calcium ion (Ca2+) mobilization" BROAD []
synonym: "calcium mobilization" BROAD []
synonym: "cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "cytoplasmic release of stored calcium ion (Ca2+)" BROAD []
synonym: "cytosolic release of sequestered calcium ion (Ca2+)" EXACT []
synonym: "cytosolic release of stored calcium ion (Ca2+)" EXACT []
synonym: "release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "release of sequestered calcium ion into cytoplasm" BROAD []
synonym: "release of stored calcium ion (Ca2+)" BROAD []
synonym: "release of stored calcium ion (Ca2+) into cytoplasm" BROAD []
synonym: "release of stored calcium ion (Ca2+) into cytosol" EXACT []
is_a: GO:0051283 ! negative regulation of sequestering of calcium ion
is_a: GO:0060402 ! calcium ion transport into cytosol

[Term]
id: GO:0051210
name: isotropic cell growth
namespace: biological_process
def: "The process by which a cell irreversibly increases in size uniformly in all directions. In general, a rounded cell morphology reflects isotropic cell growth." [GOC:ai, GOC:jic]
synonym: "uniform cell growth" RELATED []
is_a: GO:0016049 ! cell growth

[Term]
id: GO:0051211
name: anisotropic cell growth
namespace: biological_process
def: "The process by which a cell irreversibly increases in size in one or more axes, where the growth rate varies according to the direction of growth. Growth may be limited to a particular axis, axes, or to particular locations on the surface of the cell." [GOC:ai]
synonym: "non-isotropic cell growth" EXACT []
is_a: GO:0016049 ! cell growth

[Term]
id: GO:0051212
name: vanadium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with vanadium (V) ions." [GOC:ai]
subset: gosubset_prok
is_a: GO:0046914 ! transition metal ion binding

[Term]
id: GO:0051213
name: dioxygenase activity
namespace: molecular_function
def: "Catalysis of the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) substrate." [http://www.onelook.com/]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0051214
name: RNA virus induced gene silencing
namespace: biological_process
def: "Gene silencing induced by RNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing." [PMID:15165191]
synonym: "RNA VIGS" EXACT []
synonym: "RNA virus-induced gene silencing" EXACT []
is_a: GO:0009616 ! virus induced gene silencing

[Term]
id: GO:0051215
name: DNA virus induced gene silencing
namespace: biological_process
def: "Gene silencing induced by DNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing." [PMID:15165191]
synonym: "DNA VIGS" EXACT []
synonym: "DNA virus-induced gene silencing" EXACT []
is_a: GO:0009616 ! virus induced gene silencing

[Term]
id: GO:0051216
name: cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [http://www.onelook.com]
synonym: "cartilage biogenesis" EXACT []
synonym: "cartilage biosynthesis" EXACT []
synonym: "cartilage formation" EXACT []
synonym: "chondrogenesis" EXACT []
xref: Wikipedia:Chondrogenesis
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0001501 ! skeletal system development

[Term]
id: GO:0051217
name: molybdenum incorporation via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)
namespace: biological_process
def: "The incorporation of molybdenum into a protein via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)." [PDB:1Q16, PMID:12910261, RESID:AA0375]
subset: gosubset_prok
xref: RESID:AA0375
is_a: GO:0018197 ! peptidyl-aspartic acid modification
is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex

[Term]
id: GO:0051218
name: tungsten incorporation via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide)
namespace: biological_process
def: "The incorporation of tungsten into a protein via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide)." [PDB:1HOH, PMID:12220497, RESID:AA0376]
subset: gosubset_prok
xref: RESID:AA02376
is_a: GO:0042042 ! tungsten incorporation into tungsten-molybdopterin complex
is_a: GO:0050844 ! peptidyl-selenocysteine modification

[Term]
id: GO:0051219
name: phosphoprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phosphorylated protein." [GOC:ai]
synonym: "phosphorylated protein binding" EXACT []
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051220
name: cytoplasmic sequestering of protein
namespace: biological_process
def: "The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell." [GOC:ai]
synonym: "cytoplasmic retention of protein" EXACT []
synonym: "cytoplasmic sequestration of protein" EXACT []
synonym: "cytoplasmic storage of protein" EXACT []
synonym: "maintenance of protein location in cytoplasm" EXACT [GOC:dph, GOC:tb]
synonym: "retention of protein in cytoplasm" EXACT []
synonym: "sequestering of protein in cytoplasm" EXACT []
synonym: "sequestration of protein in cytoplasm" EXACT []
synonym: "storage of protein in cytoplasm" EXACT []
is_a: GO:0032507 ! maintenance of protein location in cell
is_a: GO:0051224 ! negative regulation of protein transport

[Term]
id: GO:0051221
name: tungsten incorporation into metallo-sulfur cluster
namespace: biological_process
def: "The incorporation of tungsten into a metallo-sulfur cluster." [GOC:ai]
subset: gosubset_prok
synonym: "tungsten incorporation into metallo-sulphur cluster" EXACT []
is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster

[Term]
id: GO:0051222
name: positive regulation of protein transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
synonym: "activation of protein transport" NARROW []
synonym: "stimulation of protein transport" NARROW []
synonym: "up regulation of protein transport" EXACT []
synonym: "up-regulation of protein transport" EXACT []
synonym: "upregulation of protein transport" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051223 ! regulation of protein transport
relationship: positively_regulates GO:0015031 ! protein transport

[Term]
id: GO:0051223
name: regulation of protein transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
is_a: GO:0070201 ! regulation of establishment of protein localization
relationship: regulates GO:0015031 ! protein transport

[Term]
id: GO:0051224
name: negative regulation of protein transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of protein transport" EXACT []
synonym: "down-regulation of protein transport" EXACT []
synonym: "downregulation of protein transport" EXACT []
synonym: "inhibition of protein transport" NARROW []
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051223 ! regulation of protein transport
relationship: negatively_regulates GO:0015031 ! protein transport

[Term]
id: GO:0051225
name: spindle assembly
namespace: biological_process
alt_id: GO:0051226
alt_id: GO:0051227
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:mtg_sensu, GOC:rg, GOC:tb]
synonym: "bipolar spindle biosynthesis" EXACT []
synonym: "bipolar spindle formation" EXACT []
synonym: "meiotic spindle assembly" NARROW []
synonym: "meiotic spindle biogenesis" NARROW []
synonym: "meiotic spindle biosynthesis" NARROW []
synonym: "meiotic spindle formation" NARROW []
synonym: "mitotic spindle assembly" NARROW []
synonym: "mitotic spindle biogenesis" NARROW []
synonym: "mitotic spindle biosynthesis" NARROW []
synonym: "mitotic spindle formation" NARROW []
synonym: "spindle assembly involved in meiosis" NARROW []
synonym: "spindle assembly involved in mitosis" NARROW []
synonym: "spindle biogenesis" EXACT []
synonym: "spindle biogenesis involved in meiosis" NARROW []
synonym: "spindle biogenesis involved in mitosis" NARROW []
synonym: "spindle biosynthesis" EXACT []
synonym: "spindle formation" EXACT []
synonym: "spindle formation involved in meiosis" NARROW []
synonym: "spindle formation involved in mitosis" NARROW []
is_a: GO:0007051 ! spindle organization
is_a: GO:0070925 ! organelle assembly

[Term]
id: GO:0051228
name: mitotic spindle disassembly
namespace: biological_process
def: "The controlled breakdown of the spindle during a mitotic cell cycle." [GOC:ai]
synonym: "mitotic spindle breakdown" EXACT []
synonym: "mitotic spindle catabolism" EXACT []
synonym: "mitotic spindle degradation" EXACT []
synonym: "spindle breakdown during mitosis" EXACT []
synonym: "spindle degradation during mitosis" EXACT []
synonym: "spindle disassembly during mitosis" EXACT []
is_a: GO:0007052 ! mitotic spindle organization
is_a: GO:0051230 ! spindle disassembly

[Term]
id: GO:0051229
name: meiotic spindle disassembly
namespace: biological_process
def: "The controlled breakdown of the spindle during a meiotic cell cycle." [GOC:ai]
synonym: "meiotic spindle breakdown" EXACT []
synonym: "meiotic spindle catabolism" EXACT []
synonym: "meiotic spindle degradation" EXACT []
synonym: "spindle breakdown during meiosis" EXACT []
synonym: "spindle degradation during meiosis" EXACT []
synonym: "spindle disassembly during meiosis" EXACT []
is_a: GO:0000212 ! meiotic spindle organization
is_a: GO:0051230 ! spindle disassembly

[Term]
id: GO:0051230
name: spindle disassembly
namespace: biological_process
def: "The controlled breakdown of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai]
synonym: "spindle breakdown" EXACT []
synonym: "spindle catabolism" EXACT []
synonym: "spindle degradation" EXACT []
is_a: GO:0007051 ! spindle organization
is_a: GO:0022411 ! cellular component disassembly

[Term]
id: GO:0051231
name: spindle elongation
namespace: biological_process
def: "The cell cycle process whereby the distance is lengthened between poles of the spindle." [GOC:ai]
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007051 ! spindle organization

[Term]
id: GO:0051232
name: meiotic spindle elongation
namespace: biological_process
def: "The lengthening of the distance between poles of the spindle during a meiotic cell cycle." [GOC:ai]
synonym: "spindle elongation during meiosis" EXACT []
is_a: GO:0051231 ! spindle elongation
relationship: part_of GO:0000212 ! meiotic spindle organization

[Term]
id: GO:0051233
name: spindle midzone
namespace: cellular_component
def: "The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]
synonym: "spindle equator" EXACT []
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0005819 ! spindle

[Term]
id: GO:0051234
name: establishment of localization
namespace: biological_process
def: "The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0008150 ! biological_process
relationship: part_of GO:0051179 ! localization

[Term]
id: GO:0051235
name: maintenance of location
namespace: biological_process
def: "Any process by which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "retention" NARROW []
synonym: "sequestering" NARROW []
synonym: "storage" NARROW []
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0051179 ! localization

[Term]
id: GO:0051236
name: establishment of RNA localization
namespace: biological_process
def: "The directed movement of RNA to a specific location." [GOC:ai]
synonym: "RNA positioning" EXACT []
synonym: "RNA recruitment" EXACT []
is_a: GO:0051234 ! establishment of localization
relationship: part_of GO:0006403 ! RNA localization

[Term]
id: GO:0051237
name: maintenance of RNA location
namespace: biological_process
def: "Any process by which RNA is maintained in a location and prevented from moving elsewhere." [GOC:ai]
synonym: "maintenance of RNA localization" RELATED [GOC:dph, GOC:tb]
synonym: "RNA retention" EXACT []
is_a: GO:0051235 ! maintenance of location
relationship: part_of GO:0006403 ! RNA localization

[Term]
id: GO:0051238
name: sequestering of metal ion
namespace: biological_process
def: "The process of binding or confining metal ions such that they are separated from other components of a biological system." [GOC:ai]
subset: gosubset_prok
synonym: "metal ion retention" EXACT []
synonym: "metal ion sequestering" EXACT []
synonym: "metal ion sequestration" EXACT []
synonym: "metal ion storage" EXACT []
synonym: "retention of metal ion" EXACT []
synonym: "sequestration of metal ion" EXACT []
synonym: "storage of metal ion" EXACT []
is_a: GO:0051235 ! maintenance of location

[Term]
id: GO:0051239
name: regulation of multicellular organismal process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0032501 ! multicellular organismal process

[Term]
id: GO:0051240
name: positive regulation of multicellular organismal process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]
synonym: "activation of multicellular organismal process" NARROW []
synonym: "stimulation of multicellular organismal process" NARROW []
synonym: "up regulation of multicellular organismal process" EXACT []
synonym: "up-regulation of multicellular organismal process" EXACT []
synonym: "upregulation of multicellular organismal process" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: positively_regulates GO:0032501 ! multicellular organismal process

[Term]
id: GO:0051241
name: negative regulation of multicellular organismal process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]
synonym: "down regulation of multicellular organismal process" EXACT []
synonym: "down-regulation of multicellular organismal process" EXACT []
synonym: "downregulation of multicellular organismal process" EXACT []
synonym: "inhibition of multicellular organismal process" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: negatively_regulates GO:0032501 ! multicellular organismal process

[Term]
id: GO:0051245
name: negative regulation of cellular defense response
namespace: biological_process
def: "Any process that stops, prevents, or reduces the rate of the cellular defense response." [GOC:ai]
synonym: "down regulation of cellular defense response" EXACT []
synonym: "down-regulation of cellular defense response" EXACT []
synonym: "downregulation of cellular defense response" EXACT []
synonym: "inhibition of cellular defense response" NARROW []
synonym: "negative regulation of cellular defence response" EXACT []
is_a: GO:0010185 ! regulation of cellular defense response
is_a: GO:0031348 ! negative regulation of defense response
relationship: negatively_regulates GO:0006968 ! cellular defense response

[Term]
id: GO:0051246
name: regulation of protein metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of protein metabolism" EXACT []
is_a: GO:0060255 ! regulation of macromolecule metabolic process
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0019538 ! protein metabolic process

[Term]
id: GO:0051247
name: positive regulation of protein metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]
subset: gosubset_prok
synonym: "activation of protein metabolic process" NARROW []
synonym: "positive regulation of protein metabolism" EXACT []
synonym: "stimulation of protein metabolic process" NARROW []
synonym: "up regulation of protein metabolic process" EXACT []
synonym: "up-regulation of protein metabolic process" EXACT []
synonym: "upregulation of protein metabolic process" EXACT []
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: positively_regulates GO:0019538 ! protein metabolic process

[Term]
id: GO:0051248
name: negative regulation of protein metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of protein metabolic process" EXACT []
synonym: "down-regulation of protein metabolic process" EXACT []
synonym: "downregulation of protein metabolic process" EXACT []
synonym: "inhibition of protein metabolic process" NARROW []
synonym: "negative regulation of protein metabolism" EXACT []
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: negatively_regulates GO:0019538 ! protein metabolic process

[Term]
id: GO:0051249
name: regulation of lymphocyte activation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lymphocyte activation." [GOC:ai]
is_a: GO:0002694 ! regulation of leukocyte activation
relationship: regulates GO:0046649 ! lymphocyte activation

[Term]
id: GO:0051250
name: negative regulation of lymphocyte activation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte activation." [GOC:ai]
synonym: "down regulation of lymphocyte activation" EXACT []
synonym: "down-regulation of lymphocyte activation" EXACT []
synonym: "downregulation of lymphocyte activation" EXACT []
synonym: "inhibition of lymphocyte activation" NARROW []
is_a: GO:0002695 ! negative regulation of leukocyte activation
is_a: GO:0051249 ! regulation of lymphocyte activation
relationship: negatively_regulates GO:0046649 ! lymphocyte activation

[Term]
id: GO:0051251
name: positive regulation of lymphocyte activation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte activation." [GOC:ai]
synonym: "activation of lymphocyte activation" NARROW []
synonym: "stimulation of lymphocyte activation" NARROW []
synonym: "up regulation of lymphocyte activation" EXACT []
synonym: "up-regulation of lymphocyte activation" EXACT []
synonym: "upregulation of lymphocyte activation" EXACT []
is_a: GO:0002696 ! positive regulation of leukocyte activation
is_a: GO:0051249 ! regulation of lymphocyte activation
relationship: positively_regulates GO:0046649 ! lymphocyte activation

[Term]
id: GO:0051252
name: regulation of RNA metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of RNA metabolism" EXACT []
is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0016070 ! RNA metabolic process

[Term]
id: GO:0051253
name: negative regulation of RNA metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of RNA metabolic process" EXACT []
synonym: "down-regulation of RNA metabolic process" EXACT []
synonym: "downregulation of RNA metabolic process" EXACT []
synonym: "inhibition of RNA metabolic process" NARROW []
synonym: "negative regulation of RNA metabolism" EXACT []
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: negatively_regulates GO:0016070 ! RNA metabolic process

[Term]
id: GO:0051254
name: positive regulation of RNA metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]
subset: gosubset_prok
synonym: "activation of RNA metabolic process" NARROW []
synonym: "positive regulation of RNA metabolism" EXACT []
synonym: "stimulation of RNA metabolic process" NARROW []
synonym: "up regulation of RNA metabolic process" EXACT []
synonym: "up-regulation of RNA metabolic process" EXACT []
synonym: "upregulation of RNA metabolic process" EXACT []
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: positively_regulates GO:0016070 ! RNA metabolic process

[Term]
id: GO:0051255
name: spindle midzone assembly
namespace: biological_process
def: "The cell cycle process whereby aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]
synonym: "spindle midzone biogenesis" EXACT []
synonym: "spindle midzone biosynthesis" EXACT []
synonym: "spindle midzone formation" EXACT []
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0022402 ! cell cycle process
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0051225 ! spindle assembly

[Term]
id: GO:0051256
name: spindle midzone assembly involved in mitosis
namespace: biological_process
def: "The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, during the process of mitosis." [GOC:ai, GOC:rg, GOC:tb]
synonym: "mitotic spindle midzone assembly" RELATED []
synonym: "mitotic spindle midzone biogenesis" EXACT []
synonym: "mitotic spindle midzone biosynthesis" EXACT []
synonym: "mitotic spindle midzone formation" EXACT []
synonym: "spindle midzone biogenesis involved in mitosis" EXACT []
synonym: "spindle midzone formation involved in mitosis" EXACT []
is_a: GO:0051255 ! spindle midzone assembly

[Term]
id: GO:0051257
name: spindle midzone assembly involved in meiosis
namespace: biological_process
def: "The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, during the process of meiosis." [GOC:ai, GOC:rg, GOC:tb]
synonym: "meiotic spindle midzone assembly" RELATED []
synonym: "meiotic spindle midzone biogenesis" EXACT []
synonym: "meiotic spindle midzone biosynthesis" EXACT []
synonym: "meiotic spindle midzone formation" EXACT []
synonym: "spindle midzone biogenesis involved in meiosis" EXACT []
synonym: "spindle midzone biosynthesis involved in meiosis" EXACT []
synonym: "spindle midzone formation involved in meiosis" EXACT []
is_a: GO:0051255 ! spindle midzone assembly

[Term]
id: GO:0051258
name: protein polymerization
namespace: biological_process
def: "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "protein polymer biosynthesis" EXACT []
synonym: "protein polymer biosynthetic process" EXACT []
synonym: "protein polymer formation" EXACT []
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0051259
name: protein oligomerization
namespace: biological_process
def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
subset: gosubset_prok
synonym: "protein oligomer assembly" EXACT []
synonym: "protein oligomer biosynthesis" EXACT []
synonym: "protein oligomer biosynthetic process" EXACT []
synonym: "protein oligomer formation" EXACT []
is_a: GO:0006461 ! protein complex assembly

[Term]
id: GO:0051260
name: protein homooligomerization
namespace: biological_process
def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
subset: gosubset_prok
synonym: "protein homooligomer assembly" EXACT []
synonym: "protein homooligomer biosynthesis" EXACT []
synonym: "protein homooligomer biosynthetic process" EXACT []
synonym: "protein homooligomer formation" EXACT []
synonym: "protein homooligomerization activity" RELATED []
is_a: GO:0051259 ! protein oligomerization

[Term]
id: GO:0051261
name: protein depolymerization
namespace: biological_process
def: "The process by which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "protein polymer breakdown" EXACT []
synonym: "protein polymer catabolic process" EXACT []
synonym: "protein polymer catabolism" EXACT []
synonym: "protein polymer degradation" EXACT []
is_a: GO:0043624 ! cellular protein complex disassembly

[Term]
id: GO:0051262
name: protein tetramerization
namespace: biological_process
def: "The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]
subset: gosubset_prok
synonym: "protein tetramer assembly" EXACT []
synonym: "protein tetramer biosynthesis" EXACT []
synonym: "protein tetramer biosynthetic process" EXACT []
synonym: "protein tetramer formation" EXACT []
is_a: GO:0051259 ! protein oligomerization

[Term]
id: GO:0051263
name: microcin E492 biosynthetic process by siderophore ester modification of peptidyl-serine
namespace: biological_process
def: "The modification of serine to N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine as found in microcin E492 produced from the mceA gene in plasmid pJAM229 of the E. coli VCS257 strain and the K. pneumoniae RYC492 strain." [RESID:AA0374]
subset: gosubset_prok
synonym: "microcin E492 anabolism by siderophore ester modification of peptidyl-serine" EXACT []
synonym: "microcin E492 formation by siderophore ester modification of peptidyl-serine" EXACT []
synonym: "microcin E492 synthesis by siderophore ester modification of peptidyl-serine" EXACT []
xref: RESID:AA0374
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0018350 ! protein amino acid esterification

[Term]
id: GO:0051264
name: mono-olein transacylation activity
namespace: molecular_function
def: "Catalysis of the reaction: mono-olein (mono-oleoylglycerol) + mono-olein = diolein (dioleoylglycerol) + glycerol. Mono-olein is the monoglyceride formed from oleic acid, 9-octodecenoic acid." [GOC:ai, PMID:15364929]
synonym: "acyl-CoA-independent mono-olein transacylation" EXACT []
synonym: "MOG transacylation" EXACT []
synonym: "mono-oleoylglycerol O-acyltransferase activity" EXACT []
synonym: "mono-oleoylglycerol transacylase activity" EXACT []
synonym: "monoolein transacylation" EXACT []
synonym: "monooleoylglycerol O-acyltransferase activity" EXACT []
synonym: "monooleoylglycerol transacylase activity" EXACT []
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity

[Term]
id: GO:0051265
name: diolein transacylation activity
namespace: molecular_function
def: "Catalysis of the reaction: diolein (dioleoylglycerol) + mono-olein (mono-oleoylglycerol) = triolein (trioleoylglycerol) + glycerol. Mono-olein is the monoglyceride formed from oleic acid, 9-octodecenoic acid; triolein or trioleoylglycerol is also known as olein." [GOC:ai, PMID:15364929]
synonym: "acyl-CoA-independent diolein transacylation" EXACT []
synonym: "dioleoylglycerol O-acyltransferase activity" EXACT []
synonym: "dioleoylglycerol transacylase activity" EXACT []
synonym: "DOG transacylation" EXACT []
is_a: GO:0016411 ! acylglycerol O-acyltransferase activity

[Term]
id: GO:0051266
name: sirohydrochlorin ferrochelatase activity
namespace: molecular_function
def: "Catalysis of the reaction: sirohydrochlorin + Fe2+ = siroheme + 2 H+." [EC:4.99.1.4, MetaCyc:SIROHEME-FERROCHELAT-RXN]
subset: gosubset_prok
synonym: "CysG" RELATED [EC:4.99.1.4]
synonym: "Met8P" RELATED [EC:4.99.1.4]
synonym: "SirB" RELATED [EC:4.99.1.4]
synonym: "siroheme ferro-lyase (sirohydrochlorin-forming)" EXACT [EC:4.99.1.4]
synonym: "siroheme synthase activity" BROAD []
synonym: "sirohydrochlorin ferro-lyase activity" EXACT []
xref: EC:4.99.1.4
xref: MetaCyc:SIROHEME-FERROCHELAT-RXN
is_a: GO:0004325 ! ferrochelatase activity

[Term]
id: GO:0051267
name: CP2 mannose-ethanolamine phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ethanolamine phosphate (EtN-P) + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2." [PMID:14985347, PMID:15452134]
synonym: "addition of ethanolamine phosphate to mannose of GPI precursor CP2" EXACT []
synonym: "CP2 ethanolamine phosphate transferase activity" EXACT []
synonym: "CP2 EtN-P transferase activity" EXACT []
synonym: "CP2 phosphoethanolamine transferase activity" EXACT []
synonym: "gpi7 activity" RELATED []
is_a: GO:0051377 ! mannose-ethanolamine phosphotransferase activity

[Term]
id: GO:0051268
name: alpha-keto amide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic." [GOC:ai, PMID:15564669]
xref: EC:1.2.-.-
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0051269
name: alpha-keto ester reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic." [GOC:ai, PMID:15564669]
xref: EC:1.2.-.-
is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors

[Term]
id: GO:0051270
name: regulation of cellular component movement
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl]
subset: gosubset_prok
synonym: "regulation of cell movement" EXACT []
is_a: GO:0032879 ! regulation of localization
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0006928 ! cellular component movement

[Term]
id: GO:0051271
name: negative regulation of cellular component movement
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl]
subset: gosubset_prok
synonym: "down regulation of cell motility" EXACT []
synonym: "down-regulation of cell motility" EXACT []
synonym: "downregulation of cell motility" EXACT []
synonym: "inhibition of cell motility" NARROW []
synonym: "negative regulation of cell movement" EXACT []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051270 ! regulation of cellular component movement
relationship: negatively_regulates GO:0006928 ! cellular component movement

[Term]
id: GO:0051272
name: positive regulation of cellular component movement
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl]
subset: gosubset_prok
synonym: "activation of cell motility" NARROW []
synonym: "positive regulation of cell movement" EXACT []
synonym: "stimulation of cell motility" NARROW []
synonym: "up regulation of cell motility" EXACT []
synonym: "up-regulation of cell motility" EXACT []
synonym: "upregulation of cell motility" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051270 ! regulation of cellular component movement
relationship: positively_regulates GO:0006928 ! cellular component movement

[Term]
id: GO:0051273
name: beta-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds." [GOC:ai]
subset: gosubset_prok
synonym: "beta-glucan metabolism" EXACT []
is_a: GO:0006073 ! cellular glucan metabolic process

[Term]
id: GO:0051274
name: beta-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-glucans." [GOC:ai]
subset: gosubset_prok
synonym: "beta-glucan anabolism" EXACT []
synonym: "beta-glucan biosynthesis" EXACT []
synonym: "beta-glucan formation" EXACT []
synonym: "beta-glucan synthesis" EXACT []
is_a: GO:0009250 ! glucan biosynthetic process
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0051275
name: beta-glucan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of beta-glucans." [GOC:ai]
subset: gosubset_prok
synonym: "beta-glucan breakdown" EXACT []
synonym: "beta-glucan catabolism" EXACT []
synonym: "beta-glucan degradation" EXACT []
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process
is_a: GO:0051273 ! beta-glucan metabolic process

[Term]
id: GO:0051276
name: chromosome organization
namespace: biological_process
alt_id: GO:0007001
alt_id: GO:0051277
def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
subset: goslim_pir
subset: goslim_pombe
subset: goslim_yeast
subset: gosubset_prok
synonym: "chromosome organisation" EXACT []
synonym: "chromosome organization and biogenesis" RELATED [GOC:mah]
synonym: "maintenance of genome integrity" RELATED []
synonym: "nuclear genome maintenance" RELATED []
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0051278
name: fungal-type cell wall polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of the polysaccharides which make up the fungal-type cell wall." [GOC:ai, GOC:mtg_sensu]
synonym: "cell wall polysaccharide anabolism" BROAD []
synonym: "cell wall polysaccharide formation" BROAD []
synonym: "cell wall polysaccharide synthesis" BROAD []
synonym: "chitin- and beta-glucan-containing cell wall polysaccharide biosynthetic process" NARROW []
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process
relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis

[Term]
id: GO:0051279
name: regulation of release of sequestered calcium ion into cytosol
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai, GOC:tb]
synonym: "regulation of calcium ion (Ca2+) mobilization" EXACT []
synonym: "regulation of calcium mobilization" EXACT []
synonym: "regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" EXACT []
synonym: "regulation of cytoplasmic release of stored calcium ion (Ca2+)" EXACT []
synonym: "regulation of release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "regulation of release of stored calcium ion (Ca2+)" BROAD []
synonym: "regulation of release of stored calcium ion (Ca2+) into cytoplasm" EXACT []
synonym: "regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT []
is_a: GO:0010522 ! regulation of calcium ion transport into cytosol
relationship: regulates GO:0051209 ! release of sequestered calcium ion into cytosol

[Term]
id: GO:0051280
name: negative regulation of release of sequestered calcium ion into cytosol
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai]
synonym: "down regulation of release of sequestered calcium ion into cytosol" EXACT []
synonym: "down-regulation of release of sequestered calcium ion into cytosol" EXACT []
synonym: "downregulation of release of sequestered calcium ion into cytosol" EXACT []
synonym: "inhibition of release of sequestered calcium ion into cytosol" NARROW []
synonym: "negative regulation of calcium ion (Ca2+) mobilization" BROAD []
synonym: "negative regulation of calcium mobilization" BROAD []
synonym: "negative regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "negative regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD []
synonym: "negative regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT []
synonym: "negative regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT []
synonym: "negative regulation of release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "negative regulation of release of sequestered calcium ion into cytoplasm" BROAD []
synonym: "negative regulation of release of stored calcium ion (Ca2+)" BROAD []
synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD []
synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT []
is_a: GO:0010523 ! negative regulation of calcium ion transport into cytosol
is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol
relationship: negatively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol

[Term]
id: GO:0051281
name: positive regulation of release of sequestered calcium ion into cytosol
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai]
synonym: "activation of release of sequestered calcium ion into cytosol" NARROW []
synonym: "positive regulation of calcium ion (Ca2+) mobilization" BROAD []
synonym: "positive regulation of calcium mobilization" BROAD []
synonym: "positive regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "positive regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD []
synonym: "positive regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT []
synonym: "positive regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT []
synonym: "positive regulation of release of sequestered calcium ion (Ca2+)" BROAD []
synonym: "positive regulation of release of sequestered calcium ion into cytoplasm" BROAD []
synonym: "positive regulation of release of stored calcium ion (Ca2+)" BROAD []
synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD []
synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT []
synonym: "stimulation of release of sequestered calcium ion into cytosol" NARROW []
synonym: "up regulation of release of sequestered calcium ion into cytosol" EXACT []
synonym: "up-regulation of release of sequestered calcium ion into cytosol" EXACT []
synonym: "upregulation of release of sequestered calcium ion into cytosol" EXACT []
is_a: GO:0010524 ! positive regulation of calcium ion transport into cytosol
is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol
relationship: positively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol

[Term]
id: GO:0051282
name: regulation of sequestering of calcium ion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]
synonym: "regulation of calcium ion (Ca2+) retention" EXACT []
synonym: "regulation of calcium ion (Ca2+) sequestering" EXACT []
synonym: "regulation of calcium ion (Ca2+) sequestration" EXACT []
synonym: "regulation of calcium ion (Ca2+) storage" EXACT []
synonym: "regulation of retention of calcium ion (Ca2+)" EXACT []
synonym: "regulation of sequestering of calcium ion (Ca2+)" EXACT []
synonym: "regulation of sequestration of calcium ion (Ca2+)" EXACT []
synonym: "regulation of storage of calcium ion (Ca2+)" EXACT []
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0032879 ! regulation of localization
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0051208 ! sequestering of calcium ion

[Term]
id: GO:0051283
name: negative regulation of sequestering of calcium ion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]
synonym: "down regulation of sequestering of calcium ion" EXACT []
synonym: "down-regulation of sequestering of calcium ion" EXACT []
synonym: "downregulation of sequestering of calcium ion" EXACT []
synonym: "inhibition of sequestering of calcium ion" NARROW []
synonym: "negative regulation of calcium ion (Ca2+) retention" EXACT []
synonym: "negative regulation of calcium ion (Ca2+) sequestering" EXACT []
synonym: "negative regulation of calcium ion (Ca2+) sequestration" EXACT []
synonym: "negative regulation of calcium ion (Ca2+) storage" EXACT []
synonym: "negative regulation of retention of calcium ion (Ca2+)" EXACT []
synonym: "negative regulation of sequestering of calcium ion (Ca2+)" EXACT []
synonym: "negative regulation of sequestration of calcium ion (Ca2+)" EXACT []
synonym: "negative regulation of storage of calcium ion (Ca2+)" EXACT []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051282 ! regulation of sequestering of calcium ion
relationship: negatively_regulates GO:0051208 ! sequestering of calcium ion

[Term]
id: GO:0051284
name: positive regulation of sequestering of calcium ion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]
synonym: "activation of sequestering of calcium ion" NARROW []
synonym: "positive regulation of calcium ion (Ca2+) retention" EXACT []
synonym: "positive regulation of calcium ion (Ca2+) sequestering" EXACT []
synonym: "positive regulation of calcium ion (Ca2+) sequestration" EXACT []
synonym: "positive regulation of calcium ion (Ca2+) storage" EXACT []
synonym: "positive regulation of retention of calcium ion (Ca2+)" EXACT []
synonym: "positive regulation of sequestering of calcium ion (Ca2+)" EXACT []
synonym: "positive regulation of sequestration of calcium ion (Ca2+)" EXACT []
synonym: "positive regulation of storage of calcium ion (Ca2+)" EXACT []
synonym: "stimulation of sequestering of calcium ion" NARROW []
synonym: "up regulation of sequestering of calcium ion" EXACT []
synonym: "up-regulation of sequestering of calcium ion" EXACT []
synonym: "upregulation of sequestering of calcium ion" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051282 ! regulation of sequestering of calcium ion
relationship: positively_regulates GO:0051208 ! sequestering of calcium ion

[Term]
id: GO:0051285
name: cell cortex of cell tip
namespace: cellular_component
def: "The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell." [GOC:ai]
synonym: "cell cortex of cell end" EXACT []
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0051286 ! cell tip

[Term]
id: GO:0051286
name: cell tip
namespace: cellular_component
def: "The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth may occur." [GOC:ai, GOC:vw]
synonym: "cell end" EXACT []
is_a: GO:0030427 ! site of polarized growth

[Term]
id: GO:0051287
name: NAD or NADH binding
namespace: molecular_function
alt_id: GO:0051288
def: "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH." [GOC:ai]
synonym: "nicotinamide adenine dinucleotide binding" EXACT []
is_a: GO:0000166 ! nucleotide binding
is_a: GO:0050662 ! coenzyme binding

[Term]
id: GO:0051289
name: protein homotetramerization
namespace: biological_process
def: "The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]
subset: gosubset_prok
synonym: "protein homotetramer assembly" EXACT []
synonym: "protein homotetramer biosynthesis" EXACT []
synonym: "protein homotetramer biosynthetic process" EXACT []
synonym: "protein homotetramer formation" EXACT []
is_a: GO:0051260 ! protein homooligomerization
is_a: GO:0051262 ! protein tetramerization

[Term]
id: GO:0051290
name: protein heterotetramerization
namespace: biological_process
def: "The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical." [GOC:go_curators]
subset: gosubset_prok
synonym: "protein heterotetramer assembly" EXACT []
synonym: "protein heterotetramer biosynthesis" EXACT []
synonym: "protein heterotetramer biosynthetic process" EXACT []
synonym: "protein heterotetramer formation" EXACT []
is_a: GO:0051262 ! protein tetramerization
is_a: GO:0051291 ! protein heterooligomerization

[Term]
id: GO:0051291
name: protein heterooligomerization
namespace: biological_process
def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]
subset: gosubset_prok
synonym: "protein heterooligomer assembly" EXACT []
synonym: "protein heterooligomer biosynthesis" EXACT []
synonym: "protein heterooligomer biosynthetic process" EXACT []
synonym: "protein heterooligomer formation" EXACT []
is_a: GO:0051259 ! protein oligomerization

[Term]
id: GO:0051292
name: nuclear pore complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex." [GOC:ai, GOC:mah]
synonym: "NPC assembly" EXACT []
synonym: "nuclear pore assembly" EXACT []
synonym: "nuclear pore biogenesis" EXACT []
synonym: "nuclear pore biosynthesis" EXACT []
synonym: "nuclear pore complex biogenesis" EXACT []
synonym: "nuclear pore complex biosynthesis" EXACT []
synonym: "nuclear pore complex formation" EXACT []
synonym: "nuclear pore formation" EXACT []
is_a: GO:0006999 ! nuclear pore organization
is_a: GO:0043623 ! cellular protein complex assembly
is_a: GO:0046931 ! pore complex assembly

[Term]
id: GO:0051293
name: establishment of spindle localization
namespace: biological_process
def: "The directed movement of the spindle to a specific location in the cell." [GOC:ai]
synonym: "spindle positioning" EXACT []
is_a: GO:0000226 ! microtubule cytoskeleton organization
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization
relationship: part_of GO:0051653 ! spindle localization

[Term]
id: GO:0051294
name: establishment of spindle orientation
namespace: biological_process
def: "Any process that set the alignment of spindle relative to other cellular structures." [GOC:ai]
synonym: "orienting of spindle" EXACT []
synonym: "spindle orientation" EXACT []
is_a: GO:0051293 ! establishment of spindle localization
relationship: part_of GO:0030010 ! establishment of cell polarity

[Term]
id: GO:0051295
name: establishment of meiotic spindle localization
namespace: biological_process
def: "The cell cycle process whereby the directed movement of the meiotic spindle to a specific location in the cell occurs." [GOC:ai]
synonym: "meiotic spindle positioning" EXACT []
synonym: "spindle positioning during meiosis" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051293 ! establishment of spindle localization
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051296
name: establishment of meiotic spindle orientation
namespace: biological_process
def: "Any process that set the alignment of meiotic spindle relative to other cellular structures." [GOC:ai]
synonym: "establishment of spindle orientation during meiosis" EXACT []
synonym: "meiotic spindle orientation" EXACT []
synonym: "orienting of meiotic spindle" EXACT []
is_a: GO:0051294 ! establishment of spindle orientation
is_a: GO:0051295 ! establishment of meiotic spindle localization

[Term]
id: GO:0051297
name: centrosome organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "centrosome organisation" EXACT [GOC:curators]
synonym: "centrosome organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0031023 ! microtubule organizing center organization

[Term]
id: GO:0051298
name: centrosome duplication
namespace: biological_process
def: "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]
synonym: "centrosome replication" EXACT []
is_a: GO:0051297 ! centrosome organization
relationship: part_of GO:0007098 ! centrosome cycle

[Term]
id: GO:0051299
name: centrosome separation
namespace: biological_process
def: "The process by which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai]
is_a: GO:0051297 ! centrosome organization
relationship: part_of GO:0007098 ! centrosome cycle

[Term]
id: GO:0051300
name: spindle pole body organization
namespace: biological_process
alt_id: GO:0051426
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "SPB maturation" RELATED [GOC:vw]
synonym: "SPB organization" EXACT []
synonym: "spindle pole body maturation" RELATED [GOC:vw]
synonym: "spindle pole body organisation" EXACT [GOC:curators]
synonym: "spindle pole body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0031023 ! microtubule organizing center organization

[Term]
id: GO:0051301
name: cell division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators]
subset: goslim_pir
subset: gosubset_prok
xref: Wikipedia:Cell_division
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0051302
name: regulation of cell division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0051301 ! cell division

[Term]
id: GO:0051303
name: establishment of chromosome localization
namespace: biological_process
def: "The directed movement of a chromosome to a specific location." [GOC:ai]
synonym: "chromosome positioning" EXACT []
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization
relationship: part_of GO:0050000 ! chromosome localization

[Term]
id: GO:0051304
name: chromosome separation
namespace: biological_process
def: "The cell cycle process whereby paired chromosomes are detached from each other. In budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions." [GOC:ai]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007059 ! chromosome segregation

[Term]
id: GO:0051305
name: chromosome movement towards spindle pole
namespace: biological_process
def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes." [GOC:ai]
synonym: "chromosome migration to spindle pole" EXACT []
synonym: "chromosome movement" BROAD []
synonym: "chromosome movement to spindle pole" EXACT []
is_a: GO:0051303 ! establishment of chromosome localization
relationship: part_of GO:0007059 ! chromosome segregation

[Term]
id: GO:0051306
name: mitotic sister chromatid separation
namespace: biological_process
def: "The process by which sister chromatids are physically detached from each other during mitosis." [GOC:ai]
synonym: "chromosome separation during mitosis" RELATED []
synonym: "mitotic chromosome separation" RELATED []
synonym: "sister chromatid separation during mitosis" EXACT []
is_a: GO:0051304 ! chromosome separation
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0051307
name: meiotic chromosome separation
namespace: biological_process
def: "The process by which chromosomes are physically detached from each other during meiosis." [GOC:ai]
synonym: "chromosome separation during meiosis" EXACT []
is_a: GO:0051304 ! chromosome separation
relationship: part_of GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0051308
name: male meiosis chromosome separation
namespace: biological_process
def: "The process by which paired chromosomes are physically detached from each other during male meiosis." [GOC:ai]
synonym: "chromosome separation during male meiosis" EXACT []
is_a: GO:0007060 ! male meiosis chromosome segregation
is_a: GO:0051307 ! meiotic chromosome separation

[Term]
id: GO:0051309
name: female meiosis chromosome separation
namespace: biological_process
def: "The process by which paired chromosomes are physically detached from each other during female meiosis." [GOC:ai]
synonym: "chromosome separation during female meiosis" EXACT []
is_a: GO:0016321 ! female meiosis chromosome segregation
is_a: GO:0051307 ! meiotic chromosome separation

[Term]
id: GO:0051310
name: metaphase plate congression
namespace: biological_process
def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ai]
synonym: "chromosome congression" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051303 ! establishment of chromosome localization
relationship: part_of GO:0007059 ! chromosome segregation

[Term]
id: GO:0051311
name: meiotic metaphase plate congression
namespace: biological_process
def: "The cell cycle process whereby chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis." [GOC:ai]
synonym: "metaphase plate congression during meiosis" EXACT []
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051310 ! metaphase plate congression
relationship: part_of GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0051312
name: chromosome decondensation
namespace: biological_process
def: "The alteration of chromosome structure from the condensed form to a relaxed disperse form." [GOC:ai]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0051313
name: attachment of spindle microtubules to chromosome
namespace: biological_process
def: "The process by which spindle microtubules become physically associated with a chromosome." [GOC:ai]
synonym: "microtubule and chromosome interaction" BROAD []
synonym: "spindle chromosome attachment" EXACT []
synonym: "spindle-chromosome interaction" BROAD []
is_a: GO:0034453 ! microtubule anchoring
relationship: part_of GO:0007059 ! chromosome segregation

[Term]
id: GO:0051314
name: attachment of spindle microtubules to mitotic chromosome
namespace: biological_process
def: "The cell cycle process whereby spindle microtubules become physically associated with a chromosome during mitosis." [GOC:ai]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051313 ! attachment of spindle microtubules to chromosome
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0051315
name: attachment of spindle microtubules to kinetochore during mitosis
namespace: biological_process
def: "The cell cycle process whereby spindle microtubules become physically associated with the proteins making up the kinetochore complex during mitosis. During mitosis, the kinetochores of sister chromosomes are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt]
is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0000070 ! mitotic sister chromatid segregation

[Term]
id: GO:0051316
name: attachment of spindle microtubules to kinetochore during meiotic chromosome segregation
namespace: biological_process
def: "The cell cycle process whereby spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiotic chromosome segregation." [GOC:ai]
synonym: "attachment of spindle microtubules to kinetochore during meiosis" RELATED []
is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0051317
name: attachment of spindle microtubules to meiotic chromosome
namespace: biological_process
def: "The cell cycle process whereby spindle microtubules become physically associated with a chromosome during meiosis." [GOC:ai]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051313 ! attachment of spindle microtubules to chromosome
relationship: part_of GO:0045132 ! meiotic chromosome segregation

[Term]
id: GO:0051318
name: G1 phase
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through G1 phase, one of two 'gap' phases in the cell cycle; G1 is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis." [GOC:ai, GOC:dph, GOC:mah]
xref: Wikipedia:G1_phase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0051325 ! interphase

[Term]
id: GO:0051319
name: G2 phase
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through G2 phase, one of two 'gap' phases in the cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." [GOC:ai, GOC:dph, GOC:mah]
xref: Wikipedia:G2_phase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0051325 ! interphase

[Term]
id: GO:0051320
name: S phase
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place." [GOC:ai, GOC:dph, GOC:mah]
xref: Wikipedia:S_phase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0051325 ! interphase

[Term]
id: GO:0051321
name: meiotic cell cycle
namespace: biological_process
def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell." [GOC:ai]
is_a: GO:0007049 ! cell cycle

[Term]
id: GO:0051322
name: anaphase
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through anaphase, the third stage of chromosome segregation in the cell cycle. Canonically, sister chromatids (or homologous chromosomes) separate and migrate towards the poles of the spindle." [GOC:dph, GOC:mah, http://www.onelook.com]
xref: NIF_Subcellular:sao21946128
xref: Wikipedia:Anaphase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0051323
name: metaphase
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through metaphase, the second stage of chromosome segregation in the cell cycle. Canonically, chromosomes become aligned on the equatorial plate of the cell." [GOC:dph, GOC:mah, http://www.onelook.com]
xref: NIF_Subcellular:sao888950834
xref: Wikipedia:Metaphase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0051324
name: prophase
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through prophase, the first stage of chromosome segregation in the cell cycle. Canonically, chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:ai, GOC:dph, GOC:mah]
xref: NIF_Subcellular:sao1856556831
xref: Wikipedia:Prophase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0051325
name: interphase
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs." [GOC:dph, GOC:mah, http://www.onelook.com]
synonym: "karyostasis" EXACT []
synonym: "resting phase" BROAD []
xref: NIF_Subcellular:sao727427771
xref: Wikipedia:Interphase
is_a: GO:0022403 ! cell cycle phase

[Term]
id: GO:0051326
name: telophase
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through telophase, the last stage of chromosome segregation in the cell cycle. Canonically, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:dph, GOC:mah, http://www.onelook.com]
xref: Wikipedia:Telophase
is_a: GO:0022403 ! cell cycle phase
relationship: part_of GO:0000279 ! M phase

[Term]
id: GO:0051327
name: M phase of meiotic cell cycle
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the meiotic cell cycle during which meiosis takes place." [GOC:ai, GOC:dph, GOC:mah]
is_a: GO:0000279 ! M phase
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051328
name: interphase of meiotic cell cycle
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of meiosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs." [GOC:ai, GOC:dph, GOC:mah]
is_a: GO:0051325 ! interphase
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051329
name: interphase of mitotic cell cycle
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs." [GOC:ai, GOC:dph, GOC:mah]
is_a: GO:0051325 ! interphase
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0051330
name: G1 phase of meiotic cell cycle
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through G1 phase, one of two 'gap' phases in the meiotic cell cycle; G1 is the interval between the completion of meiosis and the beginning of DNA synthesis." [GOC:ai, GOC:dph, GOC:mah]
is_a: GO:0051318 ! G1 phase
relationship: part_of GO:0051328 ! interphase of meiotic cell cycle

[Term]
id: GO:0051331
name: G2 phase of meiotic cell cycle
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through G2 phase, one of two 'gap' phases in the meiotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of meiosis." [GOC:ai, GOC:dph, GOC:mah]
is_a: GO:0051319 ! G2 phase
relationship: part_of GO:0051328 ! interphase of meiotic cell cycle

[Term]
id: GO:0051332
name: S phase of meiotic cell cycle
namespace: biological_process
def: "A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the meiotic cell cycle during which DNA synthesis takes place." [GOC:ai, GOC:dph, GOC:mah]
is_a: GO:0051320 ! S phase
relationship: part_of GO:0051328 ! interphase of meiotic cell cycle

[Term]
id: GO:0051333
name: meiotic nuclear envelope reassembly
namespace: biological_process
def: "The cell cycle process whereby the reformation of the nuclear envelope during meiosis occurs." [GOC:ai]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0031468 ! nuclear envelope reassembly
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051334
name: meiosis I nuclear envelope reassembly
namespace: biological_process
def: "The reformation of the nuclear envelope during meiosis I." [GOC:ai]
is_a: GO:0051333 ! meiotic nuclear envelope reassembly
relationship: part_of GO:0007127 ! meiosis I

[Term]
id: GO:0051335
name: meiosis II nuclear envelope reassembly
namespace: biological_process
def: "The reformation of the nuclear envelope during meiosis II." [GOC:ai]
is_a: GO:0051333 ! meiotic nuclear envelope reassembly
relationship: part_of GO:0007135 ! meiosis II

[Term]
id: GO:0051336
name: regulation of hydrolase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [EC:3.-.-.-, GOC:ai]
subset: gosubset_prok
synonym: "hydrolase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0051337
name: amitosis
namespace: biological_process
def: "Nuclear division that occurs by simple constriction of the nucleus without chromosome condensation or spindle formation." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "direct nuclear division" EXACT []
synonym: "Remak nuclear division" EXACT []
is_a: GO:0000280 ! nuclear division

[Term]
id: GO:0051338
name: regulation of transferase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-, GOC:ai]
subset: gosubset_prok
synonym: "transferase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0051339
name: regulation of lyase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, GOC:ai]
subset: gosubset_prok
synonym: "lyase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0051340
name: regulation of ligase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." [EC:6.-.-.-, GOC:ai]
subset: gosubset_prok
synonym: "ligase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0051341
name: regulation of oxidoreductase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-, GOC:ai]
subset: gosubset_prok
synonym: "oxidoreductase regulator" EXACT []
is_a: GO:0050790 ! regulation of catalytic activity

[Term]
id: GO:0051342
name: regulation of cyclic-nucleotide phosphodiesterase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [EC:3.1.4.17, GOC:ai, GOC:tb]
synonym: "3',5' cyclic nucleotide phosphodiesterase regulator" EXACT []
synonym: "3',5'-cyclic-AMP phosphodiesterase regulator" NARROW []
synonym: "cAMP phosphodiesterase regulator" NARROW []
synonym: "phosphodiesterase regulator" RELATED []
synonym: "regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW []
synonym: "regulation of cAMP phosphodiesterase activity" NARROW []
synonym: "regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb]
synonym: "regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb]
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0051343
name: positive regulation of cyclic-nucleotide phosphodiesterase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb]
synonym: "3',5' cyclic nucleotide phosphodiesterase activator" EXACT []
synonym: "3',5'-cyclic-AMP phosphodiesterase activator" NARROW []
synonym: "activation of cyclic nucleotide phosphodiesterase activity" NARROW []
synonym: "cAMP phosphodiesterase activator" NARROW []
synonym: "phosphodiesterase activator" RELATED []
synonym: "positive regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "positive regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW []
synonym: "positive regulation of cAMP phosphodiesterase activity" NARROW []
synonym: "positive regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb]
synonym: "positive regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb]
synonym: "stimulation of cyclic nucleotide phosphodiesterase activity" NARROW []
synonym: "up regulation of cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "up-regulation of cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "upregulation of cyclic nucleotide phosphodiesterase activity" EXACT []
is_a: GO:0051342 ! regulation of cyclic-nucleotide phosphodiesterase activity
is_a: GO:0051345 ! positive regulation of hydrolase activity

[Term]
id: GO:0051344
name: negative regulation of cyclic-nucleotide phosphodiesterase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb]
synonym: "3',5' cyclic nucleotide phosphodiesterase inhibitor" EXACT []
synonym: "3',5'-cyclic-AMP phosphodiesterase inhibitor" NARROW []
synonym: "cAMP phosphodiesterase inhibitor" NARROW []
synonym: "down regulation of cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "down-regulation of cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "downregulation of cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "inhibition of cyclic nucleotide phosphodiesterase activity" NARROW []
synonym: "negative regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT []
synonym: "negative regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW []
synonym: "negative regulation of cAMP phosphodiesterase activity" NARROW []
synonym: "negative regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb]
synonym: "negative regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb]
synonym: "phosphodiesterase inhibitor" RELATED []
is_a: GO:0051342 ! regulation of cyclic-nucleotide phosphodiesterase activity
is_a: GO:0051346 ! negative regulation of hydrolase activity

[Term]
id: GO:0051345
name: positive regulation of hydrolase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai]
subset: gosubset_prok
synonym: "activation of hydrolase activity" NARROW []
synonym: "hydrolase activator" EXACT []
synonym: "stimulation of hydrolase activity" NARROW []
synonym: "up regulation of hydrolase activity" EXACT []
synonym: "up-regulation of hydrolase activity" EXACT []
synonym: "upregulation of hydrolase activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0051346
name: negative regulation of hydrolase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of hydrolase activity" EXACT []
synonym: "down-regulation of hydrolase activity" EXACT []
synonym: "downregulation of hydrolase activity" EXACT []
synonym: "hydrolase inhibitor" EXACT []
synonym: "inhibition of hydrolase activity" NARROW []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0051347
name: positive regulation of transferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]
subset: gosubset_prok
synonym: "activation of transferase activity" NARROW []
synonym: "stimulation of transferase activity" NARROW []
synonym: "transferase activator" EXACT []
synonym: "up regulation of transferase activity" EXACT []
synonym: "up-regulation of transferase activity" EXACT []
synonym: "upregulation of transferase activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:0051348
name: negative regulation of transferase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of transferase activity" EXACT []
synonym: "down-regulation of transferase activity" EXACT []
synonym: "downregulation of transferase activity" EXACT []
synonym: "inhibition of transferase activity" NARROW []
synonym: "transferase inhibitor" EXACT []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:0051349
name: positive regulation of lyase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai]
synonym: "activation of lyase activity" NARROW []
synonym: "lyase activator" EXACT []
synonym: "stimulation of lyase activity" NARROW []
synonym: "up regulation of lyase activity" EXACT []
synonym: "up-regulation of lyase activity" EXACT []
synonym: "upregulation of lyase activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051339 ! regulation of lyase activity

[Term]
id: GO:0051350
name: negative regulation of lyase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai]
synonym: "down regulation of lyase activity" EXACT []
synonym: "down-regulation of lyase activity" EXACT []
synonym: "downregulation of lyase activity" EXACT []
synonym: "inhibition of lyase activity" NARROW []
synonym: "lyase inhibitor" EXACT []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051339 ! regulation of lyase activity

[Term]
id: GO:0051351
name: positive regulation of ligase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "activation of ligase activity" NARROW []
synonym: "ligase activator" EXACT []
synonym: "stimulation of ligase activity" NARROW []
synonym: "up regulation of ligase activity" EXACT []
synonym: "up-regulation of ligase activity" EXACT []
synonym: "upregulation of ligase activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051340 ! regulation of ligase activity

[Term]
id: GO:0051352
name: negative regulation of ligase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of ligase activity" EXACT []
synonym: "down-regulation of ligase activity" EXACT []
synonym: "downregulation of ligase activity" EXACT []
synonym: "inhibition of ligase activity" NARROW []
synonym: "ligase inhibitor" EXACT []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051340 ! regulation of ligase activity

[Term]
id: GO:0051353
name: positive regulation of oxidoreductase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai]
subset: gosubset_prok
synonym: "activation of oxidoreductase activity" NARROW []
synonym: "oxidoreductase activator" EXACT []
synonym: "stimulation of oxidoreductase activity" NARROW []
synonym: "up regulation of oxidoreductase activity" EXACT []
synonym: "up-regulation of oxidoreductase activity" EXACT []
synonym: "upregulation of oxidoreductase activity" EXACT []
is_a: GO:0043085 ! positive regulation of catalytic activity
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:0051354
name: negative regulation of oxidoreductase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of oxidoreductase activity" EXACT []
synonym: "down-regulation of oxidoreductase activity" EXACT []
synonym: "downregulation of oxidoreductase activity" EXACT []
synonym: "inhibition of oxidoreductase activity" NARROW []
synonym: "oxidoreductase inhibitor" EXACT []
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:0051355
name: proprioception during equilibrioception
namespace: biological_process
def: "The series of events during equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai]
synonym: "equilibrioception by proprioception" EXACT []
synonym: "perception of orientation with respect to gravity by proprioception" EXACT []
is_a: GO:0019230 ! proprioception
relationship: part_of GO:0050957 ! equilibrioception

[Term]
id: GO:0051356
name: visual perception during equilibrioception
namespace: biological_process
def: "The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai]
synonym: "equilibrioception by visual perception" NARROW []
synonym: "perception of orientation with respect to gravity by visual perception" EXACT []
is_a: GO:0007601 ! visual perception
relationship: part_of GO:0050957 ! equilibrioception

[Term]
id: GO:0051357
name: peptide cross-linking via 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one
namespace: biological_process
def: "The formation of a 2-keto-5-iminopiperazine protein chromophore cross-link from the alpha-amino nitrogen of residue n, a methionine, to the alpha-carboxyl carbon of residue n+1, a tyrosine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+2. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10852900, PMID:11259412, PMID:15491166, RESID:AA0377]
comment: Note that this predicted modification is now thought not to exist. See the biological process term 'peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine ; GO:0051359'.
synonym: "biosynthesis of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT []
xref: RESID:AA0377
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018206 ! peptidyl-methionine modification
is_a: GO:0018212 ! peptidyl-tyrosine modification
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0051358
name: peptide cross-linking via 2-imino-glutamic acid 5-imidazolinone glycine
namespace: biological_process
def: "The formation of the non-fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamic acid, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like non-fluorescent red chromoprotein from the sea anemone Radianthus macrodactylus." [PMID:11682051, RESID:AA0378]
comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'.
synonym: "biosynthesis of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine" EXACT []
xref: RESID:AA0378
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018200 ! peptidyl-glutamic acid modification
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0051359
name: peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine
namespace: biological_process
def: "The formation of the fluorescent protein FP611 chromophore cross-link from the alpha-carboxyl carbon of residue n, a methionine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like fluorescent chromoprotein from the sea anemone Entacmaea quadricolor." [PDB:1UIS, PDB:1XQM, PMID:10852900, PMID:12185250, PMID:12909624, PMID:15542608, RESID:AA0379]
comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'.
synonym: "biosynthesis of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine" EXACT []
xref: RESID:AA0379
is_a: GO:0018149 ! peptide cross-linking
is_a: GO:0018201 ! peptidyl-glycine modification
is_a: GO:0018206 ! peptidyl-methionine modification
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0051360
name: peptide cross-linking via L-asparagine 5-imidazolinone glycine
namespace: biological_process
def: "The formation of the fluorescent protein FP506 chromophore cross-link from the alpha-carboxyl carbon of residue n, an asparagine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10504696, RESID:AA0380]
comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'.
synonym: "biosynthesis of protein-protein cross-link via L-asparagine 5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via L-asparagine 5-imidazolinone glycine" EXACT []
xref: RESID:AA0380
is_a: GO:0018196 ! peptidyl-asparagine modification
is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0051361
name: peptide cross-linking via L-lysine 5-imidazolinone glycine
namespace: biological_process
def: "The formation of a fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10504696, RESID:AA0381]
comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'.
synonym: "biosynthesis of protein-protein cross-link via L-lysine 5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via L-lysine 5-imidazolinone glycine" EXACT []
xref: RESID:AA0381
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0051362
name: peptide cross-linking via 2-tetrahydropyridinyl-5-imidazolinone glycine
namespace: biological_process
def: "The formation of a 2-tetrahydropyridinyl-5-imidazolinone protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. In addition, the residue N lysine undergoes cyclization. The alpha-amino nitrogen is replaced by the epsilon-amino nitrogen, the peptide chain is broken, residue N-1 is released as an amide, and a double bond is formed between the alpha-carbon and the nitrogen so that a tetrahydropyridine ring results. This modification is found in the GFP-like fluorescent chromoprotein FP538 from the sea anemone Zoanthus species." [PDB:1XAE, PMID:10504696, PMID:15628861, RESID:AA0382]
comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'.
synonym: "biosynthesis of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT []
synonym: "biosynthetic process of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT []
xref: RESID:AA0382
is_a: GO:0018205 ! peptidyl-lysine modification
is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine
is_a: GO:0018298 ! protein-chromophore linkage

[Term]
id: GO:0051363
name: peptidoglycan-protein cross-linking via L-alanyl-pentaglycyl-murein
namespace: biological_process
def: "The process of linking a protein to peptidoglycan via a carboxy terminal alanine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan." [PMID:8163519, PMID:9086265, RESID:AA0383]
comment: Note that this modification may be unique to the species Finegoldia (Peptostreptococcus) magnus.
subset: gosubset_prok
xref: RESID:AA0383
is_a: GO:0018104 ! peptidoglycan-protein cross-linking
is_a: GO:0018194 ! peptidyl-alanine modification

[Term]
id: GO:0051364
name: N-terminal peptidyl-proline N-formylation
namespace: biological_process
def: "The formylation of the N-terminal proline of proteins to form the derivative N-formylproline." [PMID:12051774, PMID:5464655, RESID:AA0384]
xref: RESID:AA0384
is_a: GO:0018004 ! N-terminal protein formylation
is_a: GO:0018208 ! peptidyl-proline modification

[Term]
id: GO:0051365
name: cellular response to potassium ion starvation
namespace: biological_process
def: "A change in the state or activity of a cell (in terms of enzyme production, gene expression, etc.) as a result of deprivation of potassium ions." [GOC:sm]
synonym: "cellular response to K+ ion deprivation" EXACT []
synonym: "cellular response to K+ ion starvation" EXACT []
synonym: "cellular response to potassium ion deprivation" EXACT []
synonym: "cellular response to potassium starvation" EXACT []
is_a: GO:0009267 ! cellular response to starvation

[Term]
id: GO:0051366
name: protein amino acid decanoylation
namespace: biological_process
def: "The modification of a protein amino acid by formation of an ester or amide with decanoic acid." [GOC:jsg]
is_a: GO:0006497 ! protein amino acid lipidation
is_a: GO:0043543 ! protein amino acid acylation

[Term]
id: GO:0051367
name: peptidyl-serine decanoylation
namespace: biological_process
def: "The posttranslational decanoylation of peptidyl-serine to form peptidyl-O3-decanoyl-L-serine, typical of the protein ghrelin." [GOC:jsg, PMID:12630926, RESID:AA0385]
xref: RESID:AA0385
is_a: GO:0018209 ! peptidyl-serine modification
is_a: GO:0051366 ! protein amino acid decanoylation

[Term]
id: GO:0051368
name: peptidyl-threonine octanoylation
namespace: biological_process
def: "The posttranslational octanoylation of peptidyl-threonine to form peptidyl-O3-octanoyl-L-threonine, typical of the protein ghrelin." [GOC:jsg, PMID:11546772, RESID:AA0387]
xref: RESID:AA0386
is_a: GO:0018190 ! protein amino acid octanoylation
is_a: GO:0018210 ! peptidyl-threonine modification

[Term]
id: GO:0051369
name: peptidyl-threonine decanoylation
namespace: biological_process
def: "The posttranslational decanoylation of peptidyl-threonine to form peptidyl-O3-decanoyl-L-threonine, typical of the protein ghrelin." [GOC:jsg, PMID:11546772, RESID:AA0387]
xref: RESID:AA0387
is_a: GO:0018210 ! peptidyl-threonine modification
is_a: GO:0051366 ! protein amino acid decanoylation

[Term]
id: GO:0051370
name: ZASP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Z-band alternatively spliced PDZ motif protein (ZASP). ZASP is a Z-band protein specifically expressed in heart and skeletal muscle. This protein contains N-terminal PDZ domain and C-terminal LIM domain." [PMID:10427098, PMID:11699871]
synonym: "Z-band alternatively spliced PDZ-motif protein binding" EXACT []
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0051371
name: muscle alpha-actinin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc." [PMID:10984498, PMID:11699871, PMID:15014165]
synonym: "alpha-actinin 2 binding" NARROW []
synonym: "alpha-actinin 3 binding" NARROW []
is_a: GO:0051393 ! alpha-actinin binding

[Term]
id: GO:0051372
name: nonmuscle alpha-actinin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with nonmuscle isoforms of actinin. Nonmuscle alpha-actinin is found at the leading edge of motile cells, cell adhesion sites, focal contacts and along actin stress fibers in migrating cells." [PMID:15014165]
synonym: "alpha-actinin 1 binding" NARROW []
synonym: "alpha-actinin 4 binding" EXACT []
is_a: GO:0051393 ! alpha-actinin binding

[Term]
id: GO:0051373
name: FATZ binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a family of FATZ proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components." [PMID:10984498, PMID:11699871]
synonym: "calsarcin binding" EXACT []
synonym: "filamin-, actinin- and telethonin-binding protein of the Z-disc of striated muscle" EXACT []
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0051374
name: FATZ 1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with FATZ 1, a protein of FATZ family that is highly expressed in skeletal muscle fast fiber." [PMID:10984498, PMID:11699871]
synonym: "calsarcin 2 binding" EXACT []
is_a: GO:0051373 ! FATZ binding

[Term]
id: GO:0051375
name: FATZ 2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with FATZ 2, a protein of the FATZ family that is highly expressed in skeletal muscle fiber fast IIa and slow I and in cardiac muscle." [PMID:10984498, PMID:11699871]
synonym: "calsarcin 1 binding" EXACT []
is_a: GO:0051373 ! FATZ binding

[Term]
id: GO:0051376
name: FATZ 3 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with FATZ 3, a protein of the FATZ family that is highly expressed in skeletal muscle fast fiber." [PMID:10984498, PMID:11699871]
synonym: "calsarcin 3 binding" EXACT []
is_a: GO:0051373 ! FATZ binding

[Term]
id: GO:0051377
name: mannose-ethanolamine phosphotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136]
synonym: "addition of ethanolamine phosphate to mannose of GPI precursor" EXACT []
synonym: "ethanolamine phosphate transferase activity" BROAD []
synonym: "EtN-P transferase activity" EXACT []
synonym: "phosphoethanolamine transferase activity" BROAD []
is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups

[Term]
id: GO:0051378
name: serotonin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:ai]
synonym: "5-hydroxytryptamine binding" EXACT []
is_a: GO:0043176 ! amine binding

[Term]
id: GO:0051379
name: epinephrine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:ai]
synonym: "adrenaline binding" EXACT []
is_a: GO:0043176 ! amine binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0051380
name: norepinephrine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai]
synonym: "noradrenaline binding" EXACT []
is_a: GO:0043176 ! amine binding
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0051381
name: histamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai]
is_a: GO:0043176 ! amine binding

[Term]
id: GO:0051382
name: kinetochore assembly
namespace: biological_process
alt_id: GO:0000069
def: "The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai]
synonym: "centromere and kinetochore complex maturation" NARROW []
synonym: "centromere/kinetochore complex maturation" NARROW []
synonym: "chromosome-kinetochore attachment" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "kinetochore biogenesis" EXACT []
synonym: "kinetochore biosynthesis" EXACT []
synonym: "kinetochore formation" RELATED []
is_a: GO:0043623 ! cellular protein complex assembly
is_a: GO:0051383 ! kinetochore organization
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0034508 ! centromere complex assembly

[Term]
id: GO:0051383
name: kinetochore organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]
synonym: "kinetochore organisation" EXACT [GOC:curators]
synonym: "kinetochore organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0034621 ! cellular macromolecular complex subunit organization
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0051384
name: response to glucocorticoid stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:ai, PMID:9884123]
is_a: GO:0031960 ! response to corticosteroid stimulus

[Term]
id: GO:0051385
name: response to mineralocorticoid stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance." [GOC:ai, PMID:9884123]
is_a: GO:0031960 ! response to corticosteroid stimulus

[Term]
id: GO:0051386
name: regulation of nerve growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor receptor signaling pathway." [GOC:ai]
synonym: "regulation of nerve growth factor receptor signalling pathway" EXACT []
synonym: "regulation of NGF receptor signaling pathway" EXACT []
synonym: "regulation of NGF receptor signalling pathway" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0048011 ! nerve growth factor receptor signaling pathway

[Term]
id: GO:0051387
name: negative regulation of nerve growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the nerve growth factor receptor signaling pathway." [GOC:ai]
synonym: "down regulation of nerve growth factor receptor signaling pathway" EXACT []
synonym: "down-regulation of nerve growth factor receptor signaling pathway" EXACT []
synonym: "downregulation of nerve growth factor receptor signaling pathway" EXACT []
synonym: "inhibition of nerve growth factor receptor signaling pathway" NARROW []
synonym: "negative regulation of nerve growth factor receptor signalling pathway" EXACT []
synonym: "negative regulation of NGF receptor signaling pathway" EXACT []
synonym: "negative regulation of NGF receptor signalling pathway" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0051386 ! regulation of nerve growth factor receptor signaling pathway
relationship: negatively_regulates GO:0048011 ! nerve growth factor receptor signaling pathway

[Term]
id: GO:0051388
name: positive regulation of nerve growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of the nerve growth factor receptor signaling pathway." [GOC:ai]
synonym: "activation of nerve growth factor receptor signaling pathway" NARROW []
synonym: "positive regulation of nerve growth factor receptor signalling pathway" EXACT []
synonym: "positive regulation of NGF receptor signaling pathway" EXACT []
synonym: "positive regulation of NGF receptor signalling pathway" EXACT []
synonym: "stimulation of nerve growth factor receptor signaling pathway" NARROW []
synonym: "up regulation of nerve growth factor receptor signaling pathway" EXACT []
synonym: "up-regulation of nerve growth factor receptor signaling pathway" EXACT []
synonym: "upregulation of nerve growth factor receptor signaling pathway" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0051386 ! regulation of nerve growth factor receptor signaling pathway
relationship: positively_regulates GO:0048011 ! nerve growth factor receptor signaling pathway

[Term]
id: GO:0051389
name: inactivation of MAPKK activity
namespace: biological_process
def: "Any process that terminates the activity of the active enzyme MAP kinase kinase." [GOC:ai]
synonym: "inactivation of MAP kinase kinase activity" EXACT []
synonym: "termination of MAP kinase kinase activity" EXACT []
synonym: "termination of MAPKK activity" EXACT []
is_a: GO:0006469 ! negative regulation of protein kinase activity
relationship: part_of GO:0000165 ! MAPKKK cascade

[Term]
id: GO:0051390
name: inactivation of MAPKKK activity
namespace: biological_process
def: "Any process that terminates the activity of the active enzyme MAP kinase kinase kinase." [GOC:ai]
synonym: "inactivation of MAP kinase kinase kinase activity" EXACT []
synonym: "termination of MAP kinase kinase kinase activity" EXACT []
synonym: "termination of MAPKKK activity" EXACT []
is_a: GO:0006469 ! negative regulation of protein kinase activity
relationship: part_of GO:0000165 ! MAPKKK cascade

[Term]
id: GO:0051391
name: tRNA acetylation
namespace: biological_process
def: "The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai]
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0051392
name: tRNA N-acetyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of a tRNA." [PMID:15037780]
synonym: "tRNA cytidine N-acetyltransferase activity" EXACT []
is_a: GO:0008080 ! N-acetyltransferase activity

[Term]
id: GO:0051393
name: alpha-actinin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats." [PMID:10984498, PMID:11699871, PMID:15014165]
is_a: GO:0042805 ! actinin binding

[Term]
id: GO:0051394
name: regulation of nerve growth factor receptor activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor receptor." [GOC:ai]
synonym: "regulation of NGF receptor activity" EXACT []
is_a: GO:0010469 ! regulation of receptor activity
is_a: GO:0043393 ! regulation of protein binding
is_a: GO:0051386 ! regulation of nerve growth factor receptor signaling pathway

[Term]
id: GO:0051395
name: negative regulation of nerve growth factor receptor activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the nerve growth factor receptor." [GOC:ai]
synonym: "down regulation of nerve growth factor receptor activity" EXACT []
synonym: "down-regulation of nerve growth factor receptor activity" EXACT []
synonym: "downregulation of nerve growth factor receptor activity" EXACT []
synonym: "inhibition of nerve growth factor receptor activity" NARROW []
synonym: "negative regulation of NGF receptor activity" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:0051394 ! regulation of nerve growth factor receptor activity

[Term]
id: GO:0051396
name: positive regulation of nerve growth factor receptor activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the activity of the nerve growth factor receptor." [GOC:ai]
synonym: "activation of nerve growth factor receptor activity" NARROW []
synonym: "positive regulation of NGF receptor activity" EXACT []
synonym: "stimulation of nerve growth factor receptor activity" NARROW []
synonym: "up regulation of nerve growth factor receptor activity" EXACT []
synonym: "up-regulation of nerve growth factor receptor activity" EXACT []
synonym: "upregulation of nerve growth factor receptor activity" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:0051394 ! regulation of nerve growth factor receptor activity

[Term]
id: GO:0051397
name: N-terminal basic amino acid aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai]
comment: This term was made obsolete because it represents a gene product.
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0051398
name: N-terminal lysine aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365]
comment: This term was made obsolete because it represents a gene product.
synonym: "lysine aminopeptidase activity" BROAD []
synonym: "lysyl aminopeptidase activity" BROAD []
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0051399
name: N-terminal arginine aminopeptidase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365]
comment: This term was made obsolete because it represents a gene product.
synonym: "arginine aminopeptidase activity" BROAD []
synonym: "argininyl aminopeptidase activity" BROAD []
is_obsolete: true
replaced_by: GO:0004177

[Term]
id: GO:0051400
name: BH domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the Bcl-2 homology (BH) domain of a protein. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409]
synonym: "Bcl-2 homology domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0051401
name: CH domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the calponin homology domain of a protein, a domain of 100 residues that occurs in signaling and cytoskeletal proteins." [PMID:11911887, Prosite:PDOC50021]
synonym: "calponin homology domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0051402
name: neuron apoptosis
namespace: biological_process
def: "The process of apoptosis in neurons, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [MeSH:A.08.663]
synonym: "apoptosis of neuronal cells" EXACT []
synonym: "apoptosis of neurons" EXACT []
synonym: "neuron programmed cell death by apoptosis" EXACT []
synonym: "neuronal cell apoptosis" EXACT []
synonym: "neuronal cell programmed cell death by apoptosis" EXACT []
synonym: "programmed cell death of neuronal cells by apoptosis" EXACT []
synonym: "programmed cell death of neurons by apoptosis" EXACT []
synonym: "programmed cell death, neuronal cells" EXACT []
synonym: "programmed cell death, neurons" EXACT []
is_a: GO:0006915 ! apoptosis
is_a: GO:0070997 ! neuron death

[Term]
id: GO:0051403
name: stress-activated MAPK cascade
namespace: biological_process
def: "A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase." [GOC:ai, PMID:15936270]
synonym: "MAPK11 cascade" NARROW [GOC:add]
synonym: "MAPK12 cascade" NARROW [GOC:add]
synonym: "MAPK13 cascade" NARROW [GOC:add]
synonym: "MAPK14 cascade" NARROW [GOC:add]
synonym: "p38 cascade" NARROW [GOC:add]
synonym: "p38 MAPK signaling" EXACT []
synonym: "p38 MAPK signalling" EXACT []
synonym: "SAPK cascade" BROAD [GOC:add]
synonym: "stress-activated MAPK signaling pathway" EXACT []
synonym: "stress-activated MAPK signalling pathway" EXACT []
synonym: "stress-activated MAPKKK cascade" EXACT []
synonym: "stress-activated MAPKKK signaling pathway" EXACT []
synonym: "stress-activated MAPKKK signalling pathway" EXACT []
is_a: GO:0000165 ! MAPKKK cascade
is_a: GO:0031098 ! stress-activated protein kinase signaling pathway

[Term]
id: GO:0051404
name: clostripain activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the cleavage of Arg-Xaa bonds." [EC:3.4.22.8]
comment: This term was made obsolete because it represents a gene product.
synonym: "alpha-clostridipain" RELATED [EC:3.4.22.8]
synonym: "clostridiopeptidase B activity" EXACT []
synonym: "Clostridium histolyticum proteinase B" RELATED [EC:3.4.22.8]
xref: EC:3.4.22.8
is_obsolete: true
replaced_by: GO:0004197

[Term]
id: GO:0051405
name: microbial collagenase activity
namespace: molecular_function
def: "OBSOLETE. Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds." [EC:3.4.24.3]
comment: This term was made obsolete because it represents a gene product.
synonym: "Achromobacter iophagus collagenase" RELATED [EC:3.4.24.3]
synonym: "aspergillopeptidase C" RELATED [EC:3.4.24.3]
synonym: "azocollase activity" EXACT [EC:3.4.24.3]
synonym: "clostridiopeptidase A activity" EXACT []
synonym: "clostridiopeptidase I" RELATED [EC:3.4.24.3]
synonym: "clostridiopeptidase II" RELATED [EC:3.4.24.3]
synonym: "Clostridium histolyticum collagenase activity" NARROW [EC:3.4.24.3]
synonym: "Clostridium histolyticum proteinase A" RELATED [EC:3.4.24.3]
synonym: "collagen peptidase activity" EXACT [EC:3.4.24.3]
synonym: "collagen protease activity" EXACT [EC:3.4.24.3]
synonym: "collagenase 1 activity" EXACT []
synonym: "collagenase A activity" EXACT []
synonym: "collagenase I activity" EXACT [EC:3.4.24.3]
synonym: "collagenase MMP-1" RELATED [EC:3.4.24.3]
synonym: "kollaza" RELATED [EC:3.4.24.3]
synonym: "matirx metalloproteinase-18" RELATED [EC:3.4.24.3]
synonym: "matrix metalloproteinase-1" RELATED [EC:3.4.24.3]
synonym: "matrix metalloproteinase-8" RELATED [EC:3.4.24.3]
synonym: "metallocollagenase activity" EXACT [EC:3.4.24.3]
synonym: "metalloproteinase-1" RELATED [EC:3.4.24.3]
synonym: "nucleolysin" RELATED [EC:3.4.24.3]
synonym: "soycollagestin" RELATED [EC:3.4.24.3]
xref: EC:3.4.24.3
is_obsolete: true
replaced_by: GO:0004252

[Term]
id: GO:0051406
name: beta-actinin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with beta-actinin, a heterodimeric actin-binding protein which caps the barbed end of actin filaments and nucleates actin polymerization in a calcium-independent manner. In myofibrils it is localized in the Z-lines." [PMID:11699871, PMID:2341404, PMID:9742448]
synonym: "capZ binding" EXACT []
is_a: GO:0042805 ! actinin binding

[Term]
id: GO:0051407
name: glycerone phosphate:inorganic phosphate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out)." [GOC:ai]
synonym: "dihydroxyacetone-phosphate:inorganic phosphate antiporter activity" EXACT []
is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity

[Term]
id: GO:0051408
name: glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out)." [GOC:ai]
is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity

[Term]
id: GO:0051409
name: response to nitrosative stress
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [PMID:15925705]
is_a: GO:0006950 ! response to stress

[Term]
id: GO:0051410
name: detoxification of nitrogen compound
namespace: biological_process
def: "Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:ai]
synonym: "detoxification of nitrogenous compound" EXACT []
synonym: "nitric oxide (NO) detoxification" NARROW []
is_a: GO:0006807 ! nitrogen compound metabolic process
is_a: GO:0009636 ! response to toxin
is_a: GO:0051409 ! response to nitrosative stress

[Term]
id: GO:0051411
name: ALP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently wih ALP, actinin-associated LIM protein of the Z band. ALP is a PDZ/LIM domain protein found in the Z band." [PMID:11699871]
synonym: "actinin-associated LIM protein binding" EXACT []
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0051412
name: response to corticosterone stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses." [PMID:15240347]
is_a: GO:0051384 ! response to glucocorticoid stimulus
is_a: GO:0051385 ! response to mineralocorticoid stimulus

[Term]
id: GO:0051413
name: response to cortisone stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:11276391]
is_a: GO:0051384 ! response to glucocorticoid stimulus

[Term]
id: GO:0051414
name: response to cortisol stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:11276391]
synonym: "response to hydrocortisone stimulus" EXACT []
is_a: GO:0051384 ! response to glucocorticoid stimulus

[Term]
id: GO:0051415
name: interphase microtubule nucleation by interphase microtubule organizing center
namespace: biological_process
def: "The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation." [GOC:ai]
synonym: "IMTOC-mediated microtubule nucleation during interphase" EXACT []
synonym: "interphase microtubule nucleation by interphase microtubule organising centre" EXACT []
synonym: "interphase microtubule organizing center-mediated microtubule nucleation during interphase" EXACT []
synonym: "microtubule nucleation during interphase by IMTOC" EXACT []
synonym: "microtubule nucleation during interphase by interphase microtubule organizing center" EXACT []
is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center
relationship: part_of GO:0051325 ! interphase

[Term]
id: GO:0051416
name: myotilin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with myotilin, a structural component of the Z-discs in human skeletal and cardiac muscle. Its C-terminus contains two immunoglobulin-like domains and the unique N-terminal half has a serine-rich region, with numerous potential phosphorylation sites, and a stretch of hydrophobic amino acids. Myotilin forms homodimers and binds to alpha-actinin, F-actin, and filamin C." [PMID:11699871, PMID:15752755]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0051417
name: microtubule nucleation by spindle pole body
namespace: biological_process
def: "The 'de novo' formation of a microtubule, mediated by the spindle pole body." [GOC:ai]
synonym: "microtubule nucleation by SPB" EXACT []
synonym: "SPB-mediated microtubule nucleation" EXACT []
synonym: "spindle pole body-mediated microtubule nucleation" EXACT []
is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center

[Term]
id: GO:0051418
name: microtubule nucleation by microtubule organizing center
namespace: biological_process
def: "The 'de novo' formation of a microtubule, mediated by the microtubule organizing center." [GOC:ai]
synonym: "microtubule nucleation by microtubule organising centre" EXACT []
synonym: "microtubule nucleation by MTOC" EXACT []
synonym: "microtubule organizing center-mediated microtubule nucleation" EXACT []
synonym: "MTOC-mediated microtubule nucleation" EXACT []
is_a: GO:0007020 ! microtubule nucleation

[Term]
id: GO:0051419
name: nebulin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with nebulin, a large protein (approximately 800kD) that is anchored at the Z-disc by its C-terminal region and spans the length of the thin filament, ending at the edge of the H-zone." [PMID:11699871]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0051420
name: nebulette binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with nebulette, a 107 kDa protein associated with the I-Z-I complex of cardiac myofibrils. It shows a high degree of homology with skeletal muscle nebulin." [PMID:11699871]
is_a: GO:0008092 ! cytoskeletal protein binding

[Term]
id: GO:0051421
name: regulation of endo-1,4-beta-xylanase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endo-1,4-beta-xylanase activity, the catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai]
synonym: "endo-1,4-beta-xylanase regulator" RELATED []
synonym: "xylanase regulator" RELATED []
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0051422
name: negative regulation of endo-1,4-beta-xylanase activity
namespace: biological_process
def: "Any process that stops or reduces the rate of endo-1,4-beta-xylanase activity, the catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai]
synonym: "down regulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "down-regulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "downregulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "endo-1,4-beta-xylanase inhibitor" RELATED []
synonym: "inhibition of endo-1,4-beta-xylanase activity" NARROW []
synonym: "xylanase inhibitor" RELATED []
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:0051421 ! regulation of endo-1,4-beta-xylanase activity

[Term]
id: GO:0051423
name: positive regulation of endo-1,4-beta-xylanase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of endo-1,4-beta-xylanase activity, the catalysis of the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai]
synonym: "activation of endo-1,4-beta-xylanase activity" NARROW []
synonym: "endo-1,4-beta-xylanase activator" RELATED []
synonym: "stimulation of endo-1,4-beta-xylanase activity" NARROW []
synonym: "up regulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "up-regulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "upregulation of endo-1,4-beta-xylanase activity" EXACT []
synonym: "xylanase activator" RELATED []
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:0051421 ! regulation of endo-1,4-beta-xylanase activity

[Term]
id: GO:0051424
name: corticotropin-releasing hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland." [http://www.onelook.com]
synonym: "corticoliberin binding" EXACT []
synonym: "corticotropin-releasing factor binding" EXACT []
synonym: "CRH binding" EXACT []
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0051425
name: PTB domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a phosphotyrosine-binding (PTB) domain of a protein." [Pfam:PF02174.5, PMID:15924411]
synonym: "phosphotyrosine-interacting domain binding" EXACT []
synonym: "PID binding" BROAD []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0051427
name: hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor for hormones." [GOC:ai]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0051428
name: peptide hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor for peptide hormones." [GOC:ai]
synonym: "polypeptide hormone receptor binding" EXACT []
is_a: GO:0051427 ! hormone receptor binding

[Term]
id: GO:0051429
name: corticotropin-releasing hormone receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor for corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland." [GOC:ai]
is_a: GO:0051428 ! peptide hormone receptor binding

[Term]
id: GO:0051430
name: corticotropin-releasing hormone receptor 1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the protein corticotropin-releasing hormone receptor 1 (CRHR1). The CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on adrenocorticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system." [PMID:15134857]
synonym: "CRHR1 binding" EXACT []
is_a: GO:0051429 ! corticotropin-releasing hormone receptor binding

[Term]
id: GO:0051431
name: corticotropin-releasing hormone receptor 2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the protein corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery." [PMID:15134857]
synonym: "CRHR2 binding" EXACT []
is_a: GO:0051429 ! corticotropin-releasing hormone receptor binding

[Term]
id: GO:0051432
name: BH1 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the BH1 domain of a protein of the Bcl-2 family. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01080]
is_a: GO:0051400 ! BH domain binding

[Term]
id: GO:0051433
name: BH2 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the BH2 domain of a protein of the Bcl-2 family. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01258]
is_a: GO:0051400 ! BH domain binding

[Term]
id: GO:0051434
name: BH3 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the BH3 domain of a protein of the Bcl-2 family. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259]
is_a: GO:0051400 ! BH domain binding
is_a: GO:0070513 ! death domain binding

[Term]
id: GO:0051435
name: BH4 domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the BH4 domain of a protein of the Bcl-2 family. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein." [InterPro:IPR003093, PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01260, Prosite:PS50063]
is_a: GO:0051400 ! BH domain binding

[Term]
id: GO:0051436
name: negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity during the mitotic cell cycle." [GOC:ai, GOC:tb]
synonym: "anaphase promoting complex inhibition during mitotic cell cycle" NARROW []
synonym: "anaphase-promoting complex inhibition during mitotic cell cycle" NARROW []
synonym: "APC inhibition during mitotic cell cycle" NARROW []
synonym: "down regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
synonym: "down-regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
synonym: "downregulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
synonym: "inhibition of ubiquitin ligase activity during mitotic cell cycle" NARROW []
synonym: "mitotic anaphase promoting complex inhibition" NARROW []
synonym: "mitotic anaphase promoting complex inhibitor" NARROW []
synonym: "mitotic anaphase-promoting complex inhibition" NARROW []
synonym: "mitotic anaphase-promoting complex inhibitor" NARROW []
synonym: "mitotic APC inhibition" NARROW []
synonym: "mitotic APC inhibitor" NARROW []
synonym: "mitotic SCF complex inhibitor" NARROW []
synonym: "mitotic ubiquitin ligase inhibitor" NARROW []
synonym: "negative regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [GOC:tb]
xref: Reactome:141405 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"
xref: Reactome:174079 "Phosphorylation of Cdh1 by Cyclin A:Cdk2"
xref: Reactome:174084 "Autodegradation of Cdh1 by Cdh1:APC/C"
xref: Reactome:174097 "Association of Emi1 with Cdh1"
xref: Reactome:174139 "Dissociation of phospho-Cdh1 from the APC/C complex"
xref: Reactome:174235 "Association of Emi1 with Cdc20"
xref: Reactome:174251 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:431778 "Association of Emi1 with Cdc20"
xref: Reactome:431783 "Association of Emi1 with Cdh1"
xref: Reactome:436737 "Dissociation of phospho-Cdh1 from the APC/C complex"
xref: Reactome:445191 "Phosphorylation of Cdh1 by Cyclin A:Cdk2"
xref: Reactome:445192 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:448932 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"
xref: Reactome:449021 "Autodegradation of Cdh1 by Cdh1:APC/C"
xref: Reactome:454348 "Association of Emi1 with Cdc20"
xref: Reactome:454353 "Association of Emi1 with Cdh1"
xref: Reactome:459047 "Dissociation of phospho-Cdh1 from the APC/C complex"
xref: Reactome:466523 "Phosphorylation of Cdh1 by Cyclin A:Cdk2"
xref: Reactome:466524 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:470049 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"
xref: Reactome:470133 "Autodegradation of Cdh1 by Cdh1:APC/C"
xref: Reactome:474438 "Association of Emi1 with Cdc20"
xref: Reactome:474443 "Association of Emi1 with Cdh1"
xref: Reactome:478330 "Dissociation of phospho-Cdh1 from the APC/C complex"
xref: Reactome:484719 "Phosphorylation of Cdh1 by Cyclin A:Cdk2"
xref: Reactome:484720 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:487749 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"
xref: Reactome:487993 "Autodegradation of Cdh1 by Cdh1:APC/C"
xref: Reactome:493083 "Association of Emi1 with Cdc20"
xref: Reactome:493091 "Association of Emi1 with Cdh1"
xref: Reactome:498061 "Dissociation of phospho-Cdh1 from the APC/C complex"
xref: Reactome:504485 "Phosphorylation of Cdh1 by Cyclin A:Cdk2"
xref: Reactome:504486 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:507705 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"
xref: Reactome:507795 "Autodegradation of Cdh1 by Cdh1:APC/C"
xref: Reactome:513062 "Dissociation of phospho-Cdh1 from the APC/C complex"
xref: Reactome:515755 "Phosphorylation of Cdh1 by Cyclin A:Cdk2"
xref: Reactome:515756 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:517641 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"
xref: Reactome:517713 "Autodegradation of Cdh1 by Cdh1:APC/C"
xref: Reactome:524789 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:530277 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:531429 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"
xref: Reactome:535628 "Phosphorylation of Cdh1 by Cyclin A:Cdk2"
xref: Reactome:535630 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:536801 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"
xref: Reactome:541310 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:542560 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"
xref: Reactome:545507 "Dissociation of phospho-Cdh1 from the APC/C complex"
xref: Reactome:546767 "Phosphorylation of Cdh1 by Cyclin A:Cdk2"
xref: Reactome:546768 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:547736 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"
xref: Reactome:547799 "Autodegradation of Cdh1 by Cdh1:APC/C"
xref: Reactome:550257 "Dissociation of phospho-Cdh1 from the APC/C complex"
xref: Reactome:551448 "Phosphorylation of Cdh1 by Cyclin A:Cdk2"
xref: Reactome:551449 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:552306 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"
xref: Reactome:552362 "Autodegradation of Cdh1 by Cdh1:APC/C"
xref: Reactome:556844 "Phosphorylation of Cdh1 by Cyclin A:Cdk2"
xref: Reactome:556846 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:558047 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"
xref: Reactome:564441 "Dissociation of phospho-Cdh1 from the APC/C complex"
xref: Reactome:566801 "Phosphorylation of Cdh1 by Cyclin A:Cdk2"
xref: Reactome:566802 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:568544 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"
xref: Reactome:568616 "Autodegradation of Cdh1 by Cdh1:APC/C"
xref: Reactome:576768 "Dissociation of phospho-Cdh1 from the APC/C complex"
xref: Reactome:579749 "Phosphorylation of Cdh1 by Cyclin A:Cdk2"
xref: Reactome:579750 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:581755 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"
xref: Reactome:581820 "Autodegradation of Cdh1 by Cdh1:APC/C"
xref: Reactome:585097 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:589600 "Dissociation of phospho-Cdh1 from the APC/C complex"
xref: Reactome:591483 "Phosphorylation of Cdh1 by Cyclin A:Cdk2"
xref: Reactome:591484 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2"
xref: Reactome:592668 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"
xref: Reactome:592727 "Autodegradation of Cdh1 by Cdh1:APC/C"
is_a: GO:0051439 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle
is_a: GO:0051444 ! negative regulation of ubiquitin-protein ligase activity

[Term]
id: GO:0051437
name: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the mitotic cell cycle." [GOC:ai, GOC:tb]
synonym: "activation of ubiquitin ligase activity during mitotic cell cycle" NARROW []
synonym: "mitotic SCF complex activator" NARROW []
synonym: "mitotic ubiquitin ligase activator" NARROW []
synonym: "positive regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [GOC:tb]
synonym: "stimulation of ubiquitin ligase activity during mitotic cell cycle" NARROW []
synonym: "up regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
synonym: "up-regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
synonym: "upregulation of ubiquitin ligase activity during mitotic cell cycle" EXACT []
xref: Reactome:174113 "SCF-beta-TrCP mediated degradation of Emi1"
xref: Reactome:174238 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1"
xref: Reactome:176412 "Phosphorylation of the APC/C"
xref: Reactome:428868 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1"
xref: Reactome:449118 "Phosphorylation of the APC/C"
xref: Reactome:449235 "SCF-beta-TrCP mediated degradation of Emi1"
xref: Reactome:451205 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1"
xref: Reactome:470228 "Phosphorylation of the APC/C"
xref: Reactome:470354 "SCF-beta-TrCP mediated degradation of Emi1"
xref: Reactome:471996 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1"
xref: Reactome:487913 "Phosphorylation of the APC/C"
xref: Reactome:488034 "SCF-beta-TrCP mediated degradation of Emi1"
xref: Reactome:490134 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1"
xref: Reactome:507883 "Phosphorylation of the APC/C"
xref: Reactome:507995 "SCF-beta-TrCP mediated degradation of Emi1"
xref: Reactome:517775 "Phosphorylation of the APC/C"
xref: Reactome:517898 "SCF-beta-TrCP mediated degradation of Emi1"
xref: Reactome:526724 "SCF-beta-TrCP mediated degradation of Emi1"
xref: Reactome:531497 "SCF-beta-TrCP mediated degradation of Emi1"
xref: Reactome:542636 "SCF-beta-TrCP mediated degradation of Emi1"
xref: Reactome:543256 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1"
xref: Reactome:547864 "Phosphorylation of the APC/C"
xref: Reactome:547952 "SCF-beta-TrCP mediated degradation of Emi1"
xref: Reactome:552440 "Phosphorylation of the APC/C"
xref: Reactome:559617 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1"
xref: Reactome:568696 "Phosphorylation of the APC/C"
xref: Reactome:570690 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1"
xref: Reactome:581899 "Phosphorylation of the APC/C"
xref: Reactome:587111 "Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1"
xref: Reactome:592797 "Phosphorylation of the APC/C"
is_a: GO:0051439 ! regulation of ubiquitin-protein ligase activity during mitotic cell cycle
is_a: GO:0051443 ! positive regulation of ubiquitin-protein ligase activity

[Term]
id: GO:0051438
name: regulation of ubiquitin-protein ligase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, GOC:ai, GOC:tb]
synonym: "anaphase-promoting complex regulator" NARROW []
synonym: "APC regulator" NARROW []
synonym: "regulation of ubiquitin ligase activity" EXACT [GOC:tb]
synonym: "SCF complex regulator" NARROW []
synonym: "ubiquitin ligase regulator" RELATED []
synonym: "ubiquitin-protein ligase regulator" RELATED []
is_a: GO:0031396 ! regulation of protein ubiquitination
is_a: GO:0051340 ! regulation of ligase activity

[Term]
id: GO:0051439
name: regulation of ubiquitin-protein ligase activity during mitotic cell cycle
namespace: biological_process
def: "A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the mitotic cell cycle." [GOC:ai]
synonym: "mitotic anaphase-promoting complex regulator" NARROW []
synonym: "mitotic APC regulator" NARROW []
synonym: "mitotic SCF complex regulator" NARROW []
synonym: "mitotic ubiquitin ligase regulator" RELATED []
synonym: "mitotic ubiquitin-protein ligase regulator" RELATED []
synonym: "regulation of ubiquitin ligase activity during mitotic cell cycle" EXACT [GOC:tb]
xref: Reactome:176407 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
xref: Reactome:176408 "Regulation of APC/C activators between G1/S and early anaphase"
xref: Reactome:448828 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
xref: Reactome:448837 "Regulation of APC/C activators between G1/S and early anaphase"
xref: Reactome:469944 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
xref: Reactome:469953 "Regulation of APC/C activators between G1/S and early anaphase"
xref: Reactome:487652 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
xref: Reactome:487661 "Regulation of APC/C activators between G1/S and early anaphase"
xref: Reactome:507609 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
xref: Reactome:507614 "Regulation of APC/C activators between G1/S and early anaphase"
xref: Reactome:517569 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
xref: Reactome:517577 "Regulation of APC/C activators between G1/S and early anaphase"
xref: Reactome:526557 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
xref: Reactome:526696 "Regulation of APC/C activators between G1/S and early anaphase"
xref: Reactome:531349 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
xref: Reactome:531432 "Regulation of APC/C activators between G1/S and early anaphase"
xref: Reactome:536725 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
xref: Reactome:536804 "Regulation of APC/C activators between G1/S and early anaphase"
xref: Reactome:542465 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
xref: Reactome:542563 "Regulation of APC/C activators between G1/S and early anaphase"
xref: Reactome:547689 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
xref: Reactome:547692 "Regulation of APC/C activators between G1/S and early anaphase"
xref: Reactome:552274 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
xref: Reactome:552278 "Regulation of APC/C activators between G1/S and early anaphase"
xref: Reactome:557974 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
xref: Reactome:558050 "Regulation of APC/C activators between G1/S and early anaphase"
xref: Reactome:568496 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
xref: Reactome:568499 "Regulation of APC/C activators between G1/S and early anaphase"
xref: Reactome:581707 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
xref: Reactome:581710 "Regulation of APC/C activators between G1/S and early anaphase"
xref: Reactome:586009 "Regulation of APC/C activators between G1/S and early anaphase"
xref: Reactome:592615 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
xref: Reactome:592618 "Regulation of APC/C activators between G1/S and early anaphase"
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051438 ! regulation of ubiquitin-protein ligase activity
relationship: part_of GO:0000278 ! mitotic cell cycle

[Term]
id: GO:0051440
name: regulation of ubiquitin-protein ligase activity during meiotic cell cycle
namespace: biological_process
def: "A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [EC:6.3.2.19, GOC:ai, GOC:tb]
synonym: "meiotic anaphase-promoting complex regulator" NARROW []
synonym: "meiotic APC regulator" NARROW []
synonym: "meiotic SCF complex regulator" NARROW []
synonym: "meiotic ubiquitin ligase regulator" RELATED []
synonym: "meiotic ubiquitin-protein ligase regulator" RELATED []
synonym: "regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [GOC:tb]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051438 ! regulation of ubiquitin-protein ligase activity
relationship: part_of GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051441
name: positive regulation of ubiquitin-protein ligase activity during meiotic cell cycle
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb]
synonym: "activation of ubiquitin ligase activity during meiotic cell cycle" NARROW []
synonym: "meiotic SCF complex activator" NARROW []
synonym: "meiotic ubiquitin ligase activator" NARROW []
synonym: "positive regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [GOC:tb]
synonym: "stimulation of ubiquitin ligase activity during meiotic cell cycle" NARROW []
synonym: "up regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
synonym: "up-regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
synonym: "upregulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
is_a: GO:0051440 ! regulation of ubiquitin-protein ligase activity during meiotic cell cycle
is_a: GO:0051443 ! positive regulation of ubiquitin-protein ligase activity

[Term]
id: GO:0051442
name: negative regulation of ubiquitin-protein ligase activity during meiotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb]
synonym: "anaphase promoting complex inhibition during meiotic cell cycle" NARROW []
synonym: "anaphase-promoting complex inhibition during meiotic cell cycle" NARROW []
synonym: "APC inhibition during meiotic cell cycle" NARROW []
synonym: "down regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
synonym: "down-regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
synonym: "downregulation of ubiquitin ligase activity during meiotic cell cycle" EXACT []
synonym: "inhibition of ubiquitin ligase activity during meiotic cell cycle" NARROW []
synonym: "meiotic anaphase promoting complex inhibition" NARROW []
synonym: "meiotic anaphase promoting complex inhibitor" NARROW []
synonym: "meiotic anaphase-promoting complex inhibition" NARROW []
synonym: "meiotic anaphase-promoting complex inhibitor" NARROW []
synonym: "meiotic APC inhibition" NARROW []
synonym: "meiotic APC inhibitor" NARROW []
synonym: "meiotic SCF complex inhibitor" NARROW []
synonym: "meiotic ubiquitin ligase inhibitor" NARROW []
synonym: "negative regulation of ubiquitin ligase activity during meiotic cell cycle" EXACT [GOC:tb]
is_a: GO:0051440 ! regulation of ubiquitin-protein ligase activity during meiotic cell cycle
is_a: GO:0051444 ! negative regulation of ubiquitin-protein ligase activity

[Term]
id: GO:0051443
name: positive regulation of ubiquitin-protein ligase activity
namespace: biological_process
def: "Any process that activates, maintains or increases the rate of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, GOC:ai, GOC:tb]
synonym: "activation of ubiquitin ligase activity" NARROW []
synonym: "anaphase promoting complex activator" NARROW []
synonym: "anaphase-promoting complex activator" NARROW []
synonym: "APC activation" NARROW []
synonym: "APC activator" NARROW []
synonym: "positive regulation of ubiquitin ligase activity" EXACT [GOC:tb]
synonym: "SCF complex activator" NARROW []
synonym: "stimulation of ubiquitin ligase activity" NARROW []
synonym: "ubiquitin ligase activator" NARROW []
synonym: "up regulation of ubiquitin ligase activity" EXACT []
synonym: "up-regulation of ubiquitin ligase activity" EXACT []
synonym: "upregulation of ubiquitin ligase activity" EXACT []
is_a: GO:0031398 ! positive regulation of protein ubiquitination
is_a: GO:0051351 ! positive regulation of ligase activity
is_a: GO:0051438 ! regulation of ubiquitin-protein ligase activity

[Term]
id: GO:0051444
name: negative regulation of ubiquitin-protein ligase activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, GOC:ai, GOC:tb]
synonym: "anaphase promoting complex inhibition" NARROW []
synonym: "anaphase promoting complex inhibitor" NARROW []
synonym: "anaphase-promoting complex inhibition" NARROW []
synonym: "anaphase-promoting complex inhibitor" NARROW []
synonym: "APC inhibition" NARROW []
synonym: "APC inhibitor" NARROW []
synonym: "down regulation of ubiquitin ligase activity" EXACT []
synonym: "down-regulation of ubiquitin ligase activity" EXACT []
synonym: "downregulation of ubiquitin ligase activity" EXACT []
synonym: "inhibition of ubiquitin ligase activity" NARROW []
synonym: "negative regulation of ubiquitin ligase activity" EXACT [GOC:tb]
synonym: "SCF complex inhibitor" NARROW []
synonym: "ubiquitin ligase inhibitor" NARROW []
is_a: GO:0031397 ! negative regulation of protein ubiquitination
is_a: GO:0051352 ! negative regulation of ligase activity
is_a: GO:0051438 ! regulation of ubiquitin-protein ligase activity

[Term]
id: GO:0051445
name: regulation of meiotic cell cycle
namespace: biological_process
def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]
synonym: "control of meiotic cell cycle progression" EXACT []
synonym: "meiotic cell cycle control" EXACT []
synonym: "meiotic cell cycle modulation" EXACT []
synonym: "meiotic cell cycle regulation" EXACT []
synonym: "meiotic cell cycle regulator" RELATED []
synonym: "modulation of meiotic cell cycle progression" EXACT []
synonym: "regulation of meiotic cell cycle progression" EXACT []
synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051726 ! regulation of cell cycle
relationship: regulates GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051446
name: positive regulation of meiotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]
synonym: "activation of progression through meiotic cell cycle" NARROW []
synonym: "positive regulation of meiotic cell cycle progression" EXACT []
synonym: "positive regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of progression through meiotic cell cycle" NARROW []
synonym: "up regulation of progression through meiotic cell cycle" EXACT []
synonym: "up-regulation of progression through meiotic cell cycle" EXACT []
synonym: "upregulation of progression through meiotic cell cycle" EXACT []
is_a: GO:0045787 ! positive regulation of cell cycle
is_a: GO:0051445 ! regulation of meiotic cell cycle
relationship: positively_regulates GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051447
name: negative regulation of meiotic cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb]
synonym: "down regulation of progression through meiotic cell cycle" EXACT []
synonym: "down-regulation of progression through meiotic cell cycle" EXACT []
synonym: "downregulation of progression through meiotic cell cycle" EXACT []
synonym: "inhibition of progression through meiotic cell cycle" NARROW []
synonym: "negative regulation of meiotic cell cycle progression" EXACT []
synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0045786 ! negative regulation of cell cycle
is_a: GO:0051445 ! regulation of meiotic cell cycle
relationship: negatively_regulates GO:0051321 ! meiotic cell cycle

[Term]
id: GO:0051448
name: gonadotropin-releasing hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with gonadotropin-releasing hormone, a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary and it is synthesized and released by the hypothalamus." [PMID:1984190]
synonym: "gonadotrophin-releasing hormone binding" EXACT []
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0051449
name: thyrotropin-releasing hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system." [GOC:ai]
is_a: GO:0017046 ! peptide hormone binding

[Term]
id: GO:0051450
name: myoblast proliferation
namespace: biological_process
def: "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0051451
name: myoblast migration
namespace: biological_process
def: "The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle]
is_a: GO:0014812 ! muscle cell migration
relationship: part_of GO:0048741 ! skeletal muscle fiber development

[Term]
id: GO:0051452
name: intracellular pH reduction
namespace: biological_process
def: "Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai]
synonym: "cell pH reduction" EXACT []
synonym: "cellular acidification" EXACT []
synonym: "intracellular acidification" RELATED []
synonym: "reduction of cellular pH" EXACT []
synonym: "reduction of pH in cell" EXACT []
is_a: GO:0045851 ! pH reduction
is_a: GO:0051453 ! regulation of intracellular pH

[Term]
id: GO:0051453
name: regulation of intracellular pH
namespace: biological_process
def: "Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb]
synonym: "cell pH regulation" EXACT []
synonym: "cellular pH regulation" EXACT []
synonym: "pH regulation in cell" EXACT []
synonym: "regulation of cell pH" EXACT []
is_a: GO:0030641 ! regulation of cellular pH

[Term]
id: GO:0051454
name: intracellular pH elevation
namespace: biological_process
def: "Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai]
synonym: "cell pH elevation" EXACT []
synonym: "cellular alkalinization" EXACT []
synonym: "elevation of cellular pH" EXACT []
synonym: "intracellular alkalinization" EXACT []
synonym: "pH elevation in cell" EXACT []
is_a: GO:0045852 ! pH elevation
is_a: GO:0051453 ! regulation of intracellular pH

[Term]
id: GO:0051455
name: attachment of spindle microtubules to kinetochore during meiosis I
namespace: biological_process
def: "The process by which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs." [GOC:ai, GOC:clt]
comment: Note that the synonym 'monopolar attachment' refers to the normal attachment of sister chromosomes to the spindle in meiosis I, and not to the aberrant attachment of sister kinetochores to a single pole in mitosis.
synonym: "monopolar attachment" EXACT []
synonym: "sister kinetochore monoorientation" EXACT []
is_a: GO:0051316 ! attachment of spindle microtubules to kinetochore during meiotic chromosome segregation
relationship: part_of GO:0045143 ! homologous chromosome segregation

[Term]
id: GO:0051456
name: attachment of spindle microtubules to kinetochore during meiosis II
namespace: biological_process
def: "The process by which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis II. During meiosis II sister kinetochores are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt]
is_a: GO:0051316 ! attachment of spindle microtubules to kinetochore during meiotic chromosome segregation
relationship: part_of GO:0045144 ! meiotic sister chromatid segregation

[Term]
id: GO:0051457
name: maintenance of protein location in nucleus
namespace: biological_process
def: "Any process by which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai]
synonym: "maintenance of nuclear protein localization" EXACT []
synonym: "maintenance of protein localization in nucleus" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of protein location in cell nucleus" EXACT []
synonym: "nuclear protein retention" NARROW []
synonym: "nuclear protein sequestering" NARROW []
synonym: "nuclear protein sequestration" NARROW []
synonym: "protein retention in nucleus" NARROW []
synonym: "protein sequestration in nucleus" NARROW []
synonym: "protein storage in nucleus" NARROW []
synonym: "protein-nuclear retention" NARROW []
synonym: "sequestration of protein in nucleus" NARROW []
synonym: "storage of protein in nucleus" NARROW []
is_a: GO:0032507 ! maintenance of protein location in cell
relationship: part_of GO:0034504 ! protein localization in nucleus

[Term]
id: GO:0051458
name: adrenocorticotropin secretion
namespace: biological_process
def: "The regulated release of adrenocorticotropin hormone, also known as corticotropin, by a cell or group of cells. Adrenocorticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus." [PMID:11027914]
synonym: "adrenocorticotropic hormone secretion" EXACT []
synonym: "adrenotropic hormone secretion" EXACT []
synonym: "adrenotropin secretion" EXACT []
synonym: "ATCH secretion" EXACT []
synonym: "corticotropic hormone secretion" EXACT []
synonym: "corticotropin secretion" EXACT []
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0051459
name: regulation of adrenocorticotropin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of adrenocorticotropic hormone from a cell or group of cells." [GOC:ai, GOC:dph]
synonym: "regulation of adrenocorticotropic hormone secreteion" EXACT [GOC:dph]
synonym: "regulation of adrenotropin hormone secretion" EXACT []
synonym: "regulation of adrenotropin secretion" EXACT []
synonym: "regulation of ATCH secretion" EXACT []
synonym: "regulation of corticotropic hormone secretion" EXACT []
synonym: "regulation of corticotropin secretion" EXACT []
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0051458 ! adrenocorticotropin secretion

[Term]
id: GO:0051460
name: negative regulation of adrenocorticotropin secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of adrenocorticotropic hormone from a cell or group of cells." [GOC:ai]
synonym: "down regulation of adrenocorticotropin secretion" EXACT []
synonym: "down-regulation of adrenocorticotropin secretion" EXACT []
synonym: "downregulation of adrenocorticotropin secretion" EXACT []
synonym: "inhibition of adrenocorticotropin secretion" NARROW []
synonym: "negative regulation of adrenocorticotropic hormone secretion" EXACT []
synonym: "negative regulation of adrenotropic hormone secretion" EXACT []
synonym: "negative regulation of adrenotropin secretion" EXACT []
synonym: "negative regulation of ATCH secretion" EXACT []
synonym: "negative regulation of corticotropic hormone secretion" EXACT []
synonym: "negative regulation of corticotropin secretion" EXACT []
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0051459 ! regulation of adrenocorticotropin secretion
relationship: negatively_regulates GO:0051458 ! adrenocorticotropin secretion

[Term]
id: GO:0051461
name: positive regulation of adrenocorticotropin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of adrenocorticotropin hormone from a cell or group of cells." [GOC:ai]
synonym: "activation of adrenocorticotropin secretion" NARROW []
synonym: "positive regulation of adrenocorticotropic hormone secretion" EXACT []
synonym: "positive regulation of adrenotropic hormone secretion" EXACT []
synonym: "positive regulation of adrenotropin secretion" EXACT []
synonym: "positive regulation of ATCH secretion" EXACT []
synonym: "positive regulation of corticotropic hormone secretion" EXACT []
synonym: "positive regulation of corticotropin secretion" EXACT []
synonym: "stimulation of adrenocorticotropin secretion" NARROW []
synonym: "up regulation of adrenocorticotropin secretion" EXACT []
synonym: "up-regulation of adrenocorticotropin secretion" EXACT []
synonym: "upregulation of adrenocorticotropin secretion" EXACT []
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0051459 ! regulation of adrenocorticotropin secretion
relationship: positively_regulates GO:0051458 ! adrenocorticotropin secretion

[Term]
id: GO:0051462
name: regulation of cortisol secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of cortisol from a cell or group of cells." [GOC:ai]
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0043400 ! cortisol secretion

[Term]
id: GO:0051463
name: negative regulation of cortisol secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of cortisol from a cell or group of cells." [GOC:ai]
synonym: "down regulation of cortisol secretion" EXACT []
synonym: "down-regulation of cortisol secretion" EXACT []
synonym: "downregulation of cortisol secretion" EXACT []
synonym: "inhibition of cortisol secretion" NARROW []
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0051462 ! regulation of cortisol secretion
relationship: negatively_regulates GO:0043400 ! cortisol secretion

[Term]
id: GO:0051464
name: positive regulation of cortisol secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of cortisol from a cell or group of cells." [GOC:ai]
synonym: "activation of cortisol secretion" NARROW []
synonym: "stimulation of cortisol secretion" NARROW []
synonym: "up regulation of cortisol secretion" EXACT []
synonym: "up-regulation of cortisol secretion" EXACT []
synonym: "upregulation of cortisol secretion" EXACT []
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0051462 ! regulation of cortisol secretion
relationship: positively_regulates GO:0043400 ! cortisol secretion

[Term]
id: GO:0051465
name: negative regulation of corticotropin-releasing hormone secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell or group of cells." [GOC:ai]
synonym: "down regulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "down-regulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "downregulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "inhibition of corticotropin-releasing hormone secretion" NARROW []
synonym: "negative regulation of corticotropin-releasing factor secretion" EXACT []
synonym: "negative regulation of CRF secretion" EXACT []
synonym: "negative regulation of CRH secretion" EXACT []
is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
relationship: negatively_regulates GO:0043396 ! corticotropin-releasing hormone secretion

[Term]
id: GO:0051466
name: positive regulation of corticotropin-releasing hormone secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell or group of cells." [GOC:ai]
synonym: "activation of corticotropin-releasing hormone secretion" NARROW []
synonym: "positive regulation of corticotropin-releasing factor secretion" EXACT []
synonym: "positive regulation of CRF secretion" EXACT []
synonym: "positive regulation of CRH secretion" EXACT []
synonym: "stimulation of corticotropin-releasing hormone secretion" NARROW []
synonym: "up regulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "up-regulation of corticotropin-releasing hormone secretion" EXACT []
synonym: "upregulation of corticotropin-releasing hormone secretion" EXACT []
is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
relationship: positively_regulates GO:0043396 ! corticotropin-releasing hormone secretion

[Term]
id: GO:0051467
name: detection of steroid hormone stimulus
namespace: biological_process
def: "The series of events by which a steroid hormone stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
is_a: GO:0009720 ! detection of hormone stimulus
is_a: GO:0048545 ! response to steroid hormone stimulus

[Term]
id: GO:0051468
name: detection of glucocorticoid hormone stimulus
namespace: biological_process
def: "The series of events by which a glucocorticoid hormone stimulus is received by a cell and converted into a molecular signal. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:ai]
is_a: GO:0051384 ! response to glucocorticoid stimulus
is_a: GO:0051467 ! detection of steroid hormone stimulus

[Term]
id: GO:0051469
name: vesicle fusion with vacuole
namespace: biological_process
alt_id: GO:0042146
def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole." [GOC:ai]
synonym: "heterotypic vacuole fusion (non-autophagic)" RELATED []
synonym: "heterotypic vacuole fusion, non-autophagic" RELATED []
is_a: GO:0006906 ! vesicle fusion
relationship: part_of GO:0007033 ! vacuole organization

[Term]
id: GO:0051470
name: ectoine transport
namespace: biological_process
def: "The directed movement of ectoine into, out of, within or between cells by means of some external agent such as a transporter or pore. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:ai]
subset: gosubset_prok
is_a: GO:0015718 ! monocarboxylic acid transport

[Term]
id: GO:0051471
name: ectoine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of ectoine from one side of the membrane to the other. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:ai]
subset: gosubset_prok
is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity

[Term]
id: GO:0051472
name: glucosylglycerol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai]
synonym: "glucosylglycerol metabolism" EXACT []
is_a: GO:0006073 ! cellular glucan metabolic process
is_a: GO:0019400 ! alditol metabolic process

[Term]
id: GO:0051473
name: glucosylglycerol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai]
synonym: "glucosylglycerol anabolism" EXACT []
synonym: "glucosylglycerol biosynthesis" EXACT []
synonym: "glucosylglycerol formation" EXACT []
synonym: "glucosylglycerol synthesis" EXACT []
is_a: GO:0009250 ! glucan biosynthetic process
is_a: GO:0019401 ! alditol biosynthetic process
is_a: GO:0051472 ! glucosylglycerol metabolic process

[Term]
id: GO:0051474
name: glucosylglycerol transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosylglycerol from one side of the membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity

[Term]
id: GO:0051475
name: glucosylglycerol transport
namespace: biological_process
def: "The directed movement of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0008643 ! carbohydrate transport
is_a: GO:0015850 ! organic alcohol transport

[Term]
id: GO:0051476
name: mannosylglycerate transport
namespace: biological_process
def: "The directed movement of mannosylglycerate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0008643 ! carbohydrate transport

[Term]
id: GO:0051477
name: mannosylglycerate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannosylglycerate from one side of the membrane to the other." [GOC:ai, PMID:15034926]
is_a: GO:0015144 ! carbohydrate transmembrane transporter activity

[Term]
id: GO:0051478
name: mannosylglycerate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms." [GOC:ai, PMID:11562374]
synonym: "mannosylglycerate metabolism" EXACT []
is_a: GO:0044262 ! cellular carbohydrate metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0051479
name: mannosylglycerate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms." [GOC:ai]
synonym: "mannosylglycerate anabolism" EXACT []
synonym: "mannosylglycerate biosynthesis" EXACT []
synonym: "mannosylglycerate formation" EXACT []
synonym: "mannosylglycerate synthesis" EXACT []
is_a: GO:0034637 ! cellular carbohydrate biosynthetic process
is_a: GO:0051478 ! mannosylglycerate metabolic process

[Term]
id: GO:0051480
name: cytosolic calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah]
synonym: "calcium ion homeostasis in cytoplasm" BROAD []
synonym: "calcium ion homeostasis in cytosol" EXACT []
synonym: "cytoplasmic calcium ion concentration regulation" BROAD []
synonym: "cytoplasmic calcium ion homeostasis" BROAD []
synonym: "cytosolic calcium ion concentration regulation" EXACT []
synonym: "regulation of calcium ion concentration in cytoplasm" BROAD []
synonym: "regulation of calcium ion concentration in cytosol" EXACT []
synonym: "regulation of cytoplasmic calcium ion concentration" BROAD []
synonym: "regulation of cytosolic calcium ion concentration" EXACT []
is_a: GO:0006874 ! cellular calcium ion homeostasis

[Term]
id: GO:0051481
name: reduction of cytosolic calcium ion concentration
namespace: biological_process
def: "Any process that decreases the concentration of calcium ions in the cytodol." [GOC:ai]
synonym: "cytoplasmic calcium ion concentration reduction" BROAD []
synonym: "cytosolic calcium ion concentration reduction" EXACT []
synonym: "reduction of calcium ion concentration in cytoplasm" BROAD []
synonym: "reduction of calcium ion concentration in cytosol" EXACT []
synonym: "reduction of cytoplasmic calcium ion concentration" BROAD []
is_a: GO:0051480 ! cytosolic calcium ion homeostasis

[Term]
id: GO:0051482
name: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the cytosol during the process of G-protein signaling coupled to IP3 second messenger." [GOC:ai]
synonym: "elevation of calcium ion concentration in cytoplasm during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" BROAD []
synonym: "elevation of calcium ion concentration in cytosol during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT []
synonym: "elevation of cytoplasmic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" BROAD []
synonym: "elevation of cytoplasmic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" BROAD []
synonym: "elevation of cytosolic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT []
is_a: GO:0007204 ! elevation of cytosolic calcium ion concentration
relationship: part_of GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

[Term]
id: GO:0051483
name: terpenoid biosynthetic process, mevalonate-independent
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terpenoids, independent of mevalonate. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-independent biosynthesis, it is produced from pyruvate and glyceraldehyde 3-phosphate via intermediates including 1-deoxy-D-xylulose 5-phosphate." [GOC:ai]
synonym: "mevalonate-independent terpene biosynthesis" NARROW []
synonym: "mevalonate-independent terpene biosynthetic process" NARROW []
synonym: "mevalonate-independent terpenoid biosynthesis" EXACT []
synonym: "mevalonate-independent terpenoid biosynthetic process" EXACT []
synonym: "terpene biosynthesis, mevalonate-independent" NARROW []
synonym: "terpene biosynthetic process, mevalonate-independent" NARROW []
synonym: "terpenoid anabolism, mevalonate-independent" EXACT []
synonym: "terpenoid formation, mevalonate-independent" EXACT []
synonym: "terpenoid synthesis, mevalonate-independent" EXACT []
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0051484
name: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway, during terpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway during terpenoid biosynthesis. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate." [GOC:ai]
synonym: "isopentenyl diphosphate anabolism, mevalonate-independent pathway, during terpenoid anabolism" EXACT []
synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid biosynthesis" EXACT []
synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid formation" EXACT []
synonym: "isopentenyl diphosphate synthesis, mevalonate-independent pathway, during terpenoid synthesis" EXACT []
xref: MetaCyc:NONMEVIPP-PWY
is_a: GO:0019288 ! isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway
relationship: part_of GO:0051483 ! terpenoid biosynthetic process, mevalonate-independent

[Term]
id: GO:0051485
name: terpenoid biosynthetic process, mevalonate-dependent
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of terpenoids via isopentenyl diphosphate, synthesized by the mevalonate pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-dependent terpenoid biosynthesis, acetate, in the form of acetyl-CoA, is converted to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates." [GOC:ai]
synonym: "terpene biosynthesis, mevalonate-dependent" NARROW []
synonym: "terpene biosynthetic process, mevalonate-dependent" NARROW []
synonym: "terpenoid anabolism, mevalonate-dependent" EXACT []
synonym: "terpenoid formation, mevalonate-dependent" EXACT []
synonym: "terpenoid synthesis, mevalonate-dependent" EXACT []
is_a: GO:0016114 ! terpenoid biosynthetic process

[Term]
id: GO:0051486
name: isopentenyl diphosphate biosynthetic process, mevalonate pathway, during terpenoid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate pathway during terpenoid biosynthesis. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates." [GOC:ai]
synonym: "isopentenyl diphosphate anabolism, mevalonate pathway, during terpenoid anabolism" EXACT []
synonym: "isopentenyl diphosphate formation, mevalonate pathway, during terpenoid biosynthesis" EXACT []
synonym: "isopentenyl diphosphate formation, mevalonate pathway, during terpenoid formation" EXACT []
synonym: "isopentenyl diphosphate synthesis, mevalonate pathway, during terpenoid synthesis" EXACT []
is_a: GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway
relationship: part_of GO:0051485 ! terpenoid biosynthetic process, mevalonate-dependent

[Term]
id: GO:0051487
name: activation of anaphase-promoting complex activity during meiotic cell cycle
namespace: biological_process
def: "Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex during the meiotic cell cycle." [GOC:dph, GOC:mah, GOC:tb, PMID:10871297]
synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during meiotic cell cycle" EXACT []
synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during meiotic cell cycle" EXACT []
synonym: "activation of ubiquitin ligase activity of APC during meiotic cell cycle" EXACT []
synonym: "anaphase promoting complex activation during meiotic cell cycle" EXACT []
synonym: "anaphase-promoting complex activation during meiotic cell cycle" EXACT []
synonym: "APC activation during meiotic cell cycle" EXACT []
synonym: "meiotic anaphase promoting complex activation" EXACT []
synonym: "meiotic anaphase promoting complex activator" NARROW []
synonym: "meiotic anaphase-promoting complex activator" NARROW []
synonym: "meiotic APC activation" EXACT []
synonym: "meiotic APC activator" NARROW []
is_a: GO:0051441 ! positive regulation of ubiquitin-protein ligase activity during meiotic cell cycle
is_a: GO:0051488 ! activation of anaphase-promoting complex activity

[Term]
id: GO:0051488
name: activation of anaphase-promoting complex activity
namespace: biological_process
def: "Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex." [GOC:dph, GOC:mah, GOC:tb, PMID:10871297]
synonym: "activation of ubiquitin ligase activity of anaphase promoting complex" EXACT []
synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex" EXACT []
synonym: "activation of ubiquitin ligase activity of APC" EXACT []
synonym: "anaphase promoting complex activation" EXACT []
synonym: "anaphase promoting complex activator" NARROW []
synonym: "anaphase-promoting complex activation" EXACT []
synonym: "anaphase-promoting complex activator" NARROW []
synonym: "APC activation" EXACT []
synonym: "APC activator" NARROW []
is_a: GO:0051443 ! positive regulation of ubiquitin-protein ligase activity

[Term]
id: GO:0051489
name: regulation of filopodium assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
synonym: "regulation of filopodia biosynthesis" EXACT []
synonym: "regulation of filopodia formation" EXACT []
synonym: "regulation of filopodium formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0060491 ! regulation of cell projection assembly
relationship: regulates GO:0046847 ! filopodium assembly

[Term]
id: GO:0051490
name: negative regulation of filopodium assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai]
synonym: "down regulation of filopodium formation" EXACT []
synonym: "down-regulation of filopodium formation" EXACT []
synonym: "downregulation of filopodium formation" EXACT []
synonym: "inhibition of filopodium formation" NARROW []
synonym: "negative regulation of filopodia biosynthesis" EXACT []
synonym: "negative regulation of filopodia formation" EXACT []
synonym: "negative regulation of filopodium formation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031345 ! negative regulation of cell projection organization
is_a: GO:0051489 ! regulation of filopodium assembly
relationship: negatively_regulates GO:0046847 ! filopodium assembly

[Term]
id: GO:0051491
name: positive regulation of filopodium assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb]
synonym: "activation of filopodium formation" NARROW []
synonym: "positive regulation of filopodia biosynthesis" EXACT []
synonym: "positive regulation of filopodia formation" EXACT []
synonym: "positive regulation of filopodium formation" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of filopodium formation" NARROW []
synonym: "up regulation of filopodium formation" EXACT []
synonym: "up-regulation of filopodium formation" EXACT []
synonym: "upregulation of filopodium formation" EXACT []
is_a: GO:0031346 ! positive regulation of cell projection organization
is_a: GO:0051489 ! regulation of filopodium assembly
relationship: positively_regulates GO:0046847 ! filopodium assembly

[Term]
id: GO:0051492
name: regulation of stress fiber assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]
synonym: "regulation of stress fibre biosynthesis" RELATED []
synonym: "regulation of stress fibre formation" EXACT []
is_a: GO:0032231 ! regulation of actin filament bundle assembly
relationship: regulates GO:0043149 ! stress fiber assembly

[Term]
id: GO:0051493
name: regulation of cytoskeleton organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
synonym: "regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0051494
name: negative regulation of cytoskeleton organization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
synonym: "down regulation of cytoskeleton organization" EXACT []
synonym: "down-regulation of cytoskeleton organization" EXACT []
synonym: "downregulation of cytoskeleton organization" EXACT []
synonym: "inhibition of cytoskeleton organization" NARROW []
synonym: "negative regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0051493 ! regulation of cytoskeleton organization
relationship: negatively_regulates GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0051495
name: positive regulation of cytoskeleton organization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai]
synonym: "activation of cytoskeleton organization" NARROW []
synonym: "positive regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah]
synonym: "stimulation of cytoskeleton organization" NARROW []
synonym: "up regulation of cytoskeleton organization" EXACT []
synonym: "up-regulation of cytoskeleton organization" EXACT []
synonym: "upregulation of cytoskeleton organization" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0051493 ! regulation of cytoskeleton organization
relationship: positively_regulates GO:0007010 ! cytoskeleton organization

[Term]
id: GO:0051496
name: positive regulation of stress fiber assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]
synonym: "activation of stress fiber formation" NARROW []
synonym: "positive regulation of stress fibre biosynthesis" RELATED []
synonym: "positive regulation of stress fibre formation" RELATED []
synonym: "stimulation of stress fiber formation" NARROW []
synonym: "up regulation of stress fiber formation" RELATED []
synonym: "up-regulation of stress fiber formation" EXACT []
synonym: "upregulation of stress fiber formation" RELATED []
is_a: GO:0032233 ! positive regulation of actin filament bundle assembly
is_a: GO:0051492 ! regulation of stress fiber assembly
relationship: positively_regulates GO:0043149 ! stress fiber assembly

[Term]
id: GO:0051497
name: negative regulation of stress fiber assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai]
synonym: "down regulation of stress fiber formation" RELATED []
synonym: "down-regulation of stress fiber formation" EXACT []
synonym: "downregulation of stress fiber formation" RELATED []
synonym: "inhibition of stress fiber formation" NARROW []
synonym: "negative regulation of stress fibre biosynthesis" RELATED []
synonym: "negative regulation of stress fibre formation" RELATED []
is_a: GO:0032232 ! negative regulation of actin filament bundle assembly
is_a: GO:0051492 ! regulation of stress fiber assembly
relationship: negatively_regulates GO:0043149 ! stress fiber assembly

[Term]
id: GO:0051498
name: syn-copalyl diphosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: geranylgeranyl diphosphate = syn-copalyl diphosphate." [MetaCyc:RXN-8528]
synonym: "diterpene cyclase activity" BROAD []
xref: EC:5.5.1.14
xref: MetaCyc:RXN-8528
is_a: GO:0016872 ! intramolecular lyase activity

[Term]
id: GO:0051499
name: D-aminoacyl-tRNA deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA." [PMID:14527667]
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0051500
name: D-tyrosyl-tRNA(Tyr) deacylase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine resides in charged tRNA." [PMID:14527667]
is_a: GO:0051499 ! D-aminoacyl-tRNA deacylase activity

[Term]
id: GO:0051501
name: diterpene phytoalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diterpene phytoalexins, a class of diterpene formed in plants in response to fungal infection, physical damage, chemical injury, or a pathogenic process; they are sometimes referred to as plant antibiotics. Diterpenes are unsaturated hydrocarbons containing 20 carbon atoms and 4 branched methyl groups and are made up of isoprenoid units." [GOC:ai, http://www.onelook.com, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "diterpene phytoalexin metabolism" EXACT []
is_a: GO:0016101 ! diterpenoid metabolic process
is_a: GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0051502
name: diterpene phytoalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of diterpene phytoalexins, terpenoids with 20 carbons produced by plants in response to environmental stresses." [GOC:ai]
synonym: "diterpene phytoalexin anabolism" EXACT []
synonym: "diterpene phytoalexin biosynthesis" EXACT []
synonym: "diterpene phytoalexin formation" EXACT []
synonym: "diterpene phytoalexin synthesis" EXACT []
is_a: GO:0051501 ! diterpene phytoalexin metabolic process
is_a: GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0051503
name: adenine nucleotide transport
namespace: biological_process
def: "The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0015865 ! purine nucleotide transport

[Term]
id: GO:0051504
name: diterpene phytoalexin precursor biosynthetic process pathway
namespace: biological_process
def: "A branched pathway that produces the precursors to four structurally distinct types of polycyclic diterpenes. The pathway starts with the cyclization of geranylgeranyl diphosphate into ent-copalyl diphosphate and syn-copalyl diphosphate. The catalytic conversion by diterpene cyclases of these two compounds produces the four diterpene hydrocarbons which are precursors to the four structurally distinct classes of diterpene phytoalexins." [MetaCyc:PWY-2981]
synonym: "diterpene phytoalexin precursor anabolism pathway" EXACT []
synonym: "diterpene phytoalexin precursor formation pathway" EXACT []
synonym: "diterpene phytoalexin precursor synthesis pathway" EXACT []
xref: MetaCyc:PWY-2981
is_a: GO:0046246 ! terpene biosynthetic process
relationship: part_of GO:0051502 ! diterpene phytoalexin biosynthetic process

[Term]
id: GO:0051505
name: cholesterol UDP-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-cholesterol." [GOC:ai]
is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity

[Term]
id: GO:0051506
name: ergosterol UDP-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-ergosterol." [GOC:ai]
is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity

[Term]
id: GO:0051507
name: beta-sitosterol UDP-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-beta-sitosterol." [GOC:ai]
is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity

[Term]
id: GO:0051508
name: stigmasterol UDP-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-stigmasterol." [GOC:ai]
is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity

[Term]
id: GO:0051509
name: tomatidine UDP-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-tomatidine." [GOC:ai]
is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity

[Term]
id: GO:0051510
name: regulation of unidimensional cell growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of unidimensional cell growth, the process by which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0048638 ! regulation of developmental growth
relationship: regulates GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0051511
name: negative regulation of unidimensional cell growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of unidimensional cell growth, the process by which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai]
synonym: "down regulation of unidimensional cell growth" EXACT []
synonym: "down-regulation of unidimensional cell growth" EXACT []
synonym: "downregulation of unidimensional cell growth" EXACT []
synonym: "inhibition of unidimensional cell growth" NARROW []
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051510 ! regulation of unidimensional cell growth
relationship: negatively_regulates GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0051512
name: positive regulation of unidimensional cell growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of unidimensional cell growth, the process by which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai]
synonym: "activation of unidimensional cell growth" NARROW []
synonym: "stimulation of unidimensional cell growth" NARROW []
synonym: "up regulation of unidimensional cell growth" EXACT []
synonym: "up-regulation of unidimensional cell growth" EXACT []
synonym: "upregulation of unidimensional cell growth" EXACT []
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051510 ! regulation of unidimensional cell growth
relationship: positively_regulates GO:0009826 ! unidimensional cell growth

[Term]
id: GO:0051513
name: regulation of monopolar cell growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai]
is_a: GO:0051510 ! regulation of unidimensional cell growth
relationship: regulates GO:0042814 ! monopolar cell growth

[Term]
id: GO:0051514
name: negative regulation of monopolar cell growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai]
synonym: "down regulation of monopolar cell growth" EXACT []
synonym: "down-regulation of monopolar cell growth" EXACT []
synonym: "downregulation of monopolar cell growth" EXACT []
synonym: "inhibition of monopolar cell growth" NARROW []
is_a: GO:0051511 ! negative regulation of unidimensional cell growth
is_a: GO:0051513 ! regulation of monopolar cell growth
relationship: negatively_regulates GO:0042814 ! monopolar cell growth

[Term]
id: GO:0051515
name: positive regulation of monopolar cell growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai]
synonym: "stimulation of monopolar cell growth" NARROW []
synonym: "up regulation of monopolar cell growth" EXACT []
synonym: "up-regulation of monopolar cell growth" EXACT []
synonym: "upregulation of monopolar cell growth" EXACT []
is_a: GO:0051512 ! positive regulation of unidimensional cell growth
is_a: GO:0051513 ! regulation of monopolar cell growth
relationship: positively_regulates GO:0042814 ! monopolar cell growth

[Term]
id: GO:0051516
name: regulation of bipolar cell growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai]
is_a: GO:0051510 ! regulation of unidimensional cell growth
relationship: regulates GO:0042815 ! bipolar cell growth

[Term]
id: GO:0051517
name: negative regulation of bipolar cell growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai]
synonym: "down regulation of bipolar cell growth" EXACT []
synonym: "down-regulation of bipolar cell growth" EXACT []
synonym: "downregulation of bipolar cell growth" EXACT []
synonym: "inhibition of bipolar cell growth" NARROW []
is_a: GO:0051511 ! negative regulation of unidimensional cell growth
is_a: GO:0051516 ! regulation of bipolar cell growth
relationship: negatively_regulates GO:0042815 ! bipolar cell growth

[Term]
id: GO:0051518
name: positive regulation of bipolar cell growth
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai]
synonym: "stimulation of bipolar cell growth" NARROW []
synonym: "up regulation of bipolar cell growth" EXACT []
synonym: "up-regulation of bipolar cell growth" EXACT []
synonym: "upregulation of bipolar cell growth" EXACT []
is_a: GO:0051512 ! positive regulation of unidimensional cell growth
is_a: GO:0051516 ! regulation of bipolar cell growth
relationship: positively_regulates GO:0042815 ! bipolar cell growth

[Term]
id: GO:0051519
name: activation of bipolar cell growth
namespace: biological_process
def: "Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai]
synonym: "NETO" NARROW []
synonym: "new end take off" NARROW []
synonym: "new end take-off" NARROW []
is_a: GO:0051518 ! positive regulation of bipolar cell growth

[Term]
id: GO:0051520
name: termination of bipolar cell growth
namespace: biological_process
def: "Any process that stops the active process of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai]
is_a: GO:0051517 ! negative regulation of bipolar cell growth

[Term]
id: GO:0051521
name: termination of monopolar cell growth
namespace: biological_process
def: "Any process that stops the active process of bipolar cell growth, polarized growth from one end of a cell." [GOC:ai]
is_a: GO:0051514 ! negative regulation of monopolar cell growth

[Term]
id: GO:0051522
name: activation of monopolar cell growth
namespace: biological_process
def: "Any process that initiates the inactive process of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai]
is_a: GO:0051515 ! positive regulation of monopolar cell growth

[Term]
id: GO:0051523
name: cell growth mode switching, monopolar to bipolar
namespace: biological_process
def: "The process by which a cell switches from monopolar cell growth to bipolar cell growth." [GOC:ai]
is_a: GO:0051510 ! regulation of unidimensional cell growth

[Term]
id: GO:0051524
name: cell growth mode switch, bipolar to monopolar
namespace: biological_process
def: "The process by which a cell switches from bipolar cell growth to monopolar cell growth." [GOC:ai]
is_a: GO:0051510 ! regulation of unidimensional cell growth

[Term]
id: GO:0051525
name: NFAT protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system." [PMID:15928679]
synonym: "NFAT binding" EXACT []
synonym: "nuclear factor of activated T cell protein binding" EXACT []
is_a: GO:0008134 ! transcription factor binding

[Term]
id: GO:0051526
name: NFAT1 protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with NFAT1 (nuclear factor of activated T cells 1 protein), a calcium-regulated protein which acts as a transcription factor." [GOC:ai]
synonym: "NFATc2 binding" EXACT []
synonym: "NFATp binding" EXACT []
is_a: GO:0051525 ! NFAT protein binding

[Term]
id: GO:0051527
name: NFAT2 protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with NFAT2 (nuclear factor of activated T cells 2 protein), a calcium-regulated protein which acts as a transcription factor." [GOC:ai]
synonym: "NFATc binding" EXACT []
synonym: "NFATc1 binding" EXACT []
is_a: GO:0051525 ! NFAT protein binding

[Term]
id: GO:0051528
name: NFAT3 protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with NFAT3 (nuclear factor of activated T cells 3 protein), a calcium-regulated protein which acts as a transcription factor." [GOC:ai]
synonym: "NFATc4 binding" EXACT []
is_a: GO:0051525 ! NFAT protein binding

[Term]
id: GO:0051529
name: NFAT4 protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with NFAT4 (nuclear factor of activated T cells 4 protein), a calcium-regulated protein which acts as a transcription factor." [GOC:ai]
synonym: "NFATc3 binding" RELATED []
synonym: "NFATx binding" EXACT []
is_a: GO:0051525 ! NFAT protein binding

[Term]
id: GO:0051530
name: NFAT5 protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with NFAT1 (nuclear factor of activated T cells 1 protein), a member of the NFAT transcription factor family which is not calcium regulated." [GOC:ai]
synonym: "non-calcium-regulated NFAT protein binding" EXACT []
is_a: GO:0051525 ! NFAT protein binding

[Term]
id: GO:0051531
name: NFAT protein import into nucleus
namespace: biological_process
def: "The directed movement of NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors, from the cytoplasm into the nucleus. NFAT proteins are dephosphorylated in the cytoplasm by activated calcineurin, which leads to their translocation across the nuclear membrane." [PMID:11983154, PMID:15870113, PMID:15928679]
synonym: "NFAT protein import into cell nucleus" EXACT []
synonym: "NFAT protein nuclear translocation" EXACT []
synonym: "NFAT protein nucleus import" EXACT []
synonym: "NFAT protein transport from cytoplasm to nucleus" EXACT []
synonym: "NFAT protein-nucleus import" EXACT []
is_a: GO:0042991 ! transcription factor import into nucleus

[Term]
id: GO:0051532
name: regulation of NFAT protein import into nucleus
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai]
synonym: "regulation of NFAT protein import into cell nucleus" EXACT []
synonym: "regulation of NFAT protein transport from cytoplasm to nucleus" EXACT []
synonym: "regulation of NFAT protein-nucleus import" EXACT []
is_a: GO:0042990 ! regulation of transcription factor import into nucleus
relationship: regulates GO:0051531 ! NFAT protein import into nucleus

[Term]
id: GO:0051533
name: positive regulation of NFAT protein import into nucleus
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai]
synonym: "activation of NFAT protein import into nucleus" NARROW []
synonym: "positive regulation of NFAT protein import into cell nucleus" EXACT []
synonym: "positive regulation of NFAT protein transport from cytoplasm to nucleus" EXACT []
synonym: "positive regulation of NFAT protein-nucleus import" EXACT []
synonym: "stimulation of NFAT protein import into nucleus" NARROW []
synonym: "up regulation of NFAT protein import into nucleus" EXACT []
synonym: "up-regulation of NFAT protein import into nucleus" EXACT []
synonym: "upregulation of NFAT protein import into nucleus" EXACT []
is_a: GO:0042993 ! positive regulation of transcription factor import into nucleus
is_a: GO:0051532 ! regulation of NFAT protein import into nucleus
relationship: positively_regulates GO:0051531 ! NFAT protein import into nucleus

[Term]
id: GO:0051534
name: negative regulation of NFAT protein import into nucleus
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus." [GOC:ai]
synonym: "down regulation of NFAT protein import into nucleus" EXACT []
synonym: "down-regulation of NFAT protein import into nucleus" EXACT []
synonym: "downregulation of NFAT protein import into nucleus" EXACT []
synonym: "inhibition of NFAT protein import into nucleus" NARROW []
synonym: "negative regulation of NFAT protein import into cell nucleus" EXACT []
synonym: "negative regulation of NFAT protein transport from cytoplasm to nucleus" EXACT []
synonym: "negative regulation of NFAT protein-nucleus import" EXACT []
is_a: GO:0042992 ! negative regulation of transcription factor import into nucleus
is_a: GO:0051532 ! regulation of NFAT protein import into nucleus
relationship: negatively_regulates GO:0051531 ! NFAT protein import into nucleus

[Term]
id: GO:0051535
name: syntaxin-5 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-5." [GOC:ai, PMID:12388752]
is_a: GO:0019905 ! syntaxin binding

[Term]
id: GO:0051536
name: iron-sulfur cluster binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai]
synonym: "Fe/S binding" EXACT []
synonym: "iron sulfur cluster binding" EXACT []
synonym: "iron sulphur cluster binding" EXACT []
synonym: "iron-sulphur cluster binding" EXACT []
is_a: GO:0051540 ! metal cluster binding

[Term]
id: GO:0051537
name: 2 iron, 2 sulfur cluster binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, Wikipedia:Iron-sulfur_cluster]
synonym: "2 Fe 2 S cluster binding" EXACT []
synonym: "2 iron, 2 sulphur cluster binding" EXACT []
synonym: "2Fe-2S cluster binding" EXACT []
synonym: "diiron disulfide cluster binding" EXACT []
synonym: "diiron disulphide cluster binding" EXACT []
synonym: "iron-sulfur cluster 2Fe-2S binding" EXACT []
synonym: "iron-sulphur cluster 2Fe-2S binding" EXACT []
is_a: GO:0051536 ! iron-sulfur cluster binding

[Term]
id: GO:0051538
name: 3 iron, 4 sulfur cluster binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing." [GOC:ai, Wikipedia:Iron-sulfur_cluster]
synonym: "3 Fe 4 S cluster binding" EXACT []
synonym: "3 iron, 4 sulphur cluster binding" EXACT []
synonym: "3Fe-4S cluster binding" EXACT []
synonym: "iron-sulfur cluster 3Fe-4S binding" EXACT []
synonym: "iron-sulphur cluster 3Fe-4S binding" EXACT []
synonym: "triiron tetrasulfide cluster binding" EXACT []
synonym: "triiron tetrasulphide cluster binding" EXACT []
is_a: GO:0051536 ! iron-sulfur cluster binding

[Term]
id: GO:0051539
name: 4 iron, 4 sulfur cluster binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, Wikipedia:Iron-sulfur_cluster]
synonym: "4 Fe 4 S cluster binding" EXACT []
synonym: "4 iron, 4 sulphur cluster binding" EXACT []
synonym: "4Fe-4S cluster binding" EXACT []
synonym: "iron-sulfur cluster 4Fe-4S binding" EXACT []
synonym: "iron-sulphur cluster 4Fe-4S binding" EXACT []
synonym: "tetrairon tetrasulfide cluster binding" EXACT []
synonym: "tetrairon tetrasulphide cluster binding" EXACT []
is_a: GO:0051536 ! iron-sulfur cluster binding

[Term]
id: GO:0051540
name: metal cluster binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters." [GOC:jsg]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0051541
name: elastin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving elastin, a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue." [http://www.onelook.com]
synonym: "elastin metabolism" EXACT []
is_a: GO:0009100 ! glycoprotein metabolic process

[Term]
id: GO:0051542
name: elastin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of elastin, a fibrous glycoprotein found in elastic tissues such as the walls of arteries." [GOC:ai]
is_a: GO:0009101 ! glycoprotein biosynthetic process
is_a: GO:0051541 ! elastin metabolic process

[Term]
id: GO:0051543
name: regulation of elastin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai]
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
relationship: regulates GO:0051542 ! elastin biosynthetic process

[Term]
id: GO:0051544
name: positive regulation of elastin biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai]
synonym: "activation of elastin biosynthetic process" NARROW []
synonym: "stimulation of elastin biosynthetic process" NARROW []
synonym: "up regulation of elastin biosynthetic process" EXACT []
synonym: "up-regulation of elastin biosynthetic process" EXACT []
synonym: "upregulation of elastin biosynthetic process" EXACT []
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0051543 ! regulation of elastin biosynthetic process
relationship: positively_regulates GO:0051542 ! elastin biosynthetic process

[Term]
id: GO:0051545
name: negative regulation of elastin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai]
synonym: "down regulation of elastin biosynthetic process" EXACT []
synonym: "down-regulation of elastin biosynthetic process" EXACT []
synonym: "downregulation of elastin biosynthetic process" EXACT []
synonym: "inhibition of elastin biosynthetic process" NARROW []
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0051543 ! regulation of elastin biosynthetic process
relationship: negatively_regulates GO:0051542 ! elastin biosynthetic process

[Term]
id: GO:0051546
name: keratinocyte migration
namespace: biological_process
def: "The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0051547
name: regulation of keratinocyte migration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of keratinocyte migration." [GOC:ai]
is_a: GO:0030334 ! regulation of cell migration
relationship: regulates GO:0051546 ! keratinocyte migration

[Term]
id: GO:0051548
name: negative regulation of keratinocyte migration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of keratinocyte migration." [GOC:ai]
synonym: "down regulation of keratinocyte migration" EXACT []
synonym: "down-regulation of keratinocyte migration" EXACT []
synonym: "downregulation of keratinocyte migration" EXACT []
synonym: "inhibition of keratinocyte migration" NARROW []
is_a: GO:0030336 ! negative regulation of cell migration
is_a: GO:0051547 ! regulation of keratinocyte migration
relationship: negatively_regulates GO:0051546 ! keratinocyte migration

[Term]
id: GO:0051549
name: positive regulation of keratinocyte migration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of keratinocyte migration." [GOC:ai]
synonym: "activation of keratinocyte migration" NARROW []
synonym: "stimulation of keratinocyte migration" NARROW []
synonym: "up regulation of keratinocyte migration" EXACT []
synonym: "up-regulation of keratinocyte migration" EXACT []
synonym: "upregulation of keratinocyte migration" EXACT []
is_a: GO:0030335 ! positive regulation of cell migration
is_a: GO:0051547 ! regulation of keratinocyte migration
relationship: positively_regulates GO:0051546 ! keratinocyte migration

[Term]
id: GO:0051550
name: aurone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving aurones, a series of plant flavonoids that provide a yellow colour to flowers. They have the basic skeletal structure of two benzene rings joined by a linear C3 chain (C6-C3-C6). Aurones exist mostly as 6-O-glucosides." [http://cancerweb.ncl.ac.uk/]
synonym: "aurone metabolism" EXACT []
synonym: "benzalcoumaran-3-one metabolic process" EXACT []
synonym: "benzalcoumaran-3-one metabolism" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:0042440 ! pigment metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0051551
name: aurone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of aurones, a series of yellow plant pigments." [GOC:ai]
synonym: "benzalcoumaran-3-one biosynthesis" EXACT []
synonym: "benzalcoumaran-3-one biosynthetic process" EXACT []
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0051550 ! aurone metabolic process

[Term]
id: GO:0051552
name: flavone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone)." [http://www.onelook.com]
synonym: "2-phenyl-4H-1-benzopyran-4-one metabolic process" NARROW []
synonym: "2-phenyl-4H-1-benzopyran-4-one metabolism" NARROW []
synonym: "2-phenylchromone metabolic process" NARROW []
synonym: "2-phenylchromone metabolism" NARROW []
synonym: "flavone metabolism" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:0042440 ! pigment metabolic process
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0051553
name: flavone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone)." [GOC:ai]
synonym: "2-phenyl-4H-1-benzopyran-4-one biosynthesis" NARROW []
synonym: "2-phenyl-4H-1-benzopyran-4-one biosynthetic process" NARROW []
synonym: "2-phenylchromone biosynthesis" NARROW []
synonym: "2-phenylchromone biosynthetic process" NARROW []
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0051552 ! flavone metabolic process

[Term]
id: GO:0051554
name: flavonol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities." [PMID:11402179]
synonym: "flavonol metabolism" EXACT []
is_a: GO:0051552 ! flavone metabolic process

[Term]
id: GO:0051555
name: flavonol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities." [GOC:ai]
xref: MetaCyc:PWY-3101
is_a: GO:0051553 ! flavone biosynthetic process
is_a: GO:0051554 ! flavonol metabolic process

[Term]
id: GO:0051556
name: leucoanthocyanidin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids." [GOC:ai]
synonym: "leucoanthocyanidin metabolism" EXACT []
xref: MetaCyc:PWY1F-823
is_a: GO:0009812 ! flavonoid metabolic process

[Term]
id: GO:0051557
name: leucoanthocyanidin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids." [GOC:ai]
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0051556 ! leucoanthocyanidin metabolic process

[Term]
id: GO:0051558
name: phlobaphene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols." [PMID:11402179]
synonym: "phlobaphene metabolism" EXACT []
is_a: GO:0009812 ! flavonoid metabolic process
is_a: GO:0042440 ! pigment metabolic process

[Term]
id: GO:0051559
name: phlobaphene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols." [PMID:11402179]
is_a: GO:0009813 ! flavonoid biosynthetic process
is_a: GO:0046148 ! pigment biosynthetic process
is_a: GO:0051558 ! phlobaphene metabolic process

[Term]
id: GO:0051560
name: mitochondrial calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai, GOC:mah]
synonym: "calcium ion homeostasis in mitochondria" EXACT []
synonym: "calcium ion homeostasis in mitochondrion" EXACT []
synonym: "mitochondrial calcium ion concentration regulation" EXACT []
synonym: "regulation of calcium ion concentration in mitochondria" EXACT []
synonym: "regulation of calcium ion concentration in mitochondrion" EXACT []
synonym: "regulation of mitochondrial calcium ion concentration" EXACT []
is_a: GO:0006874 ! cellular calcium ion homeostasis

[Term]
id: GO:0051561
name: elevation of mitochondrial calcium ion concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in mitochondria." [GOC:ai]
synonym: "elevation of calcium ion concentration in mitochondria" EXACT []
synonym: "elevation of calcium ion concentration in mitochondrion" EXACT []
synonym: "mitochondrial calcium ion concentration elevation" EXACT []
is_a: GO:0051560 ! mitochondrial calcium ion homeostasis

[Term]
id: GO:0051562
name: reduction of mitochondrial calcium ion concentration
namespace: biological_process
def: "Any process that decreases the concentration of calcium ions in mitochondria." [GOC:ai]
synonym: "mitochondrial calcium ion concentration reduction" EXACT []
synonym: "reduction of calcium ion concentration in mitochondria" EXACT []
synonym: "reduction of calcium ion concentration in mitochondrion" EXACT []
is_a: GO:0051560 ! mitochondrial calcium ion homeostasis

[Term]
id: GO:0051563
name: smooth endoplasmic reticulum calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of calcium ions within the smooth endoplasmic reticulum of a cell or between the smooth endoplasmic reticulum and its surroundings." [GOC:ai, GOC:mah]
synonym: "calcium ion homeostasis in smooth endoplasmic reticulum" EXACT []
synonym: "calcium ion homeostasis in smooth ER" EXACT []
synonym: "regulation of calcium ion concentration in smooth endoplasmic reticulum" EXACT []
synonym: "regulation of calcium ion concentration in smooth ER" EXACT []
synonym: "regulation of smooth endoplasmic reticulum calcium ion concentration" EXACT []
synonym: "regulation of smooth ER calcium ion concentration" EXACT []
synonym: "smooth endoplasmic reticulum calcium ion concentration regulation" EXACT []
synonym: "smooth ER calcium ion concentration regulation" EXACT []
synonym: "smooth ER calcium ion homeostasis" EXACT []
is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis

[Term]
id: GO:0051564
name: elevation of smooth endoplasmic reticulum calcium ion concentration
namespace: biological_process
def: "Any process that increases the concentration of calcium ions in the smooth endoplasmic reticulum." [GOC:ai]
synonym: "elevation of calcium ion concentration in smooth endoplasmic reticulum" EXACT []
synonym: "elevation of smooth ER calcium ion concentration" EXACT []
synonym: "smooth endoplasmic reticulum calcium ion concentration elevation" EXACT []
is_a: GO:0032470 ! elevation of endoplasmic reticulum calcium ion concentration
is_a: GO:0051563 ! smooth endoplasmic reticulum calcium ion homeostasis

[Term]
id: GO:0051565
name: reduction of smooth endoplasmic reticulum calcium ion concentration
namespace: biological_process
def: "Any process that decreases the concentration of calcium ions in the smooth endoplasmic reticulum." [GOC:ai]
synonym: "reduction of calcium ion concentration in smooth endoplasmic reticulum" EXACT []
synonym: "reduction of calcium ion concentration in smooth ER" EXACT []
synonym: "reduction of smooth ER calcium ion concentration" EXACT []
synonym: "smooth endoplasmic reticulum calcium ion concentration reduction" EXACT []
synonym: "smooth ER calcium ion concentration reduction" EXACT []
is_a: GO:0032471 ! reduction of endoplasmic reticulum calcium ion concentration
is_a: GO:0051563 ! smooth endoplasmic reticulum calcium ion homeostasis

[Term]
id: GO:0051566
name: anthocyanidin-3-glucoside rhamnosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: anthocyanidin 3-glucoside + UDP-rhamnose = anthocyanidin 3-rutinoside + UDP." [PMID:8130800]
synonym: "3RT activity" BROAD []
synonym: "anthocyanidin 3-glucoside-rhamnosyltransferase activity" EXACT []
is_a: GO:0016758 ! transferase activity, transferring hexosyl groups

[Term]
id: GO:0051567
name: histone H3-K9 methylation
namespace: biological_process
def: "The modification of histone H3 by addition of a methyl group to lysine at position 9 of the histone." [GOC:ai]
synonym: "histone H3 K9 methylation" EXACT []
synonym: "histone H3K9me" EXACT []
synonym: "histone lysine H3 K9 methylation" EXACT []
is_a: GO:0034968 ! histone lysine methylation

[Term]
id: GO:0051568
name: histone H3-K4 methylation
namespace: biological_process
def: "The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai]
synonym: "histone H3 K4 methylation" EXACT []
synonym: "histone H3K4me" EXACT []
synonym: "histone lysine H3 K4 methylation" EXACT []
is_a: GO:0034968 ! histone lysine methylation

[Term]
id: GO:0051569
name: regulation of histone H3-K4 methylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:ai]
is_a: GO:0031060 ! regulation of histone methylation
relationship: regulates GO:0051568 ! histone H3-K4 methylation

[Term]
id: GO:0051570
name: regulation of histone H3-K9 methylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai]
is_a: GO:0031060 ! regulation of histone methylation
relationship: regulates GO:0051567 ! histone H3-K9 methylation

[Term]
id: GO:0051571
name: positive regulation of histone H3-K4 methylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah]
synonym: "activation of histone H3-K4 methylation" NARROW []
synonym: "stimulation of histone H3-K4 methylation" NARROW []
synonym: "up regulation of histone H3-K4 methylation" EXACT []
synonym: "up-regulation of histone H3-K4 methylation" EXACT []
synonym: "upregulation of histone H3-K4 methylation" EXACT []
is_a: GO:0031062 ! positive regulation of histone methylation
is_a: GO:0051569 ! regulation of histone H3-K4 methylation
relationship: positively_regulates GO:0051568 ! histone H3-K4 methylation

[Term]
id: GO:0051572
name: negative regulation of histone H3-K4 methylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah]
synonym: "down regulation of histone H3-K4 methylation" EXACT []
synonym: "down-regulation of histone H3-K4 methylation" EXACT []
synonym: "downregulation of histone H3-K4 methylation" EXACT []
synonym: "inhibition of histone H3-K4 methylation" NARROW []
is_a: GO:0031061 ! negative regulation of histone methylation
is_a: GO:0051569 ! regulation of histone H3-K4 methylation
relationship: negatively_regulates GO:0051568 ! histone H3-K4 methylation

[Term]
id: GO:0051573
name: negative regulation of histone H3-K9 methylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai]
synonym: "down regulation of histone H3-K9 methylation" EXACT []
synonym: "down-regulation of histone H3-K9 methylation" EXACT []
synonym: "downregulation of histone H3-K9 methylation" EXACT []
synonym: "inhibition of histone H3-K9 methylation" NARROW []
is_a: GO:0031061 ! negative regulation of histone methylation
is_a: GO:0051570 ! regulation of histone H3-K9 methylation
relationship: negatively_regulates GO:0051567 ! histone H3-K9 methylation

[Term]
id: GO:0051574
name: positive regulation of histone H3-K9 methylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai]
synonym: "activation of histone H3-K9 methylation" NARROW []
synonym: "stimulation of histone H3-K9 methylation" NARROW []
synonym: "up regulation of histone H3-K9 methylation" EXACT []
synonym: "up-regulation of histone H3-K9 methylation" EXACT []
synonym: "upregulation of histone H3-K9 methylation" EXACT []
is_a: GO:0031062 ! positive regulation of histone methylation
is_a: GO:0051570 ! regulation of histone H3-K9 methylation
relationship: positively_regulates GO:0051567 ! histone H3-K9 methylation

[Term]
id: GO:0051575
name: 5'-deoxyribose-5-phosphate lyase activity
namespace: molecular_function
def: "Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site." [PMID:11251121, PMID:16120966]
synonym: "5'-deoxyribose phosphate activity" EXACT []
synonym: "dRP lyase activity" BROAD []
synonym: "dRPase activity" BROAD []
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0051576
name: Myf5 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the muscle regulatory factor Myf5." [GOC:ai]
is_a: GO:0043426 ! MRF binding

[Term]
id: GO:0051577
name: MyoD binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the muscle regulatory factor MyoD." [GOC:ai]
is_a: GO:0043426 ! MRF binding

[Term]
id: GO:0051578
name: Mrf4 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the muscle regulatory factor Mrf4." [GOC:ai]
is_a: GO:0043426 ! MRF binding

[Term]
id: GO:0051579
name: myogenin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the muscle regulatory factor myogenin." [GOC:ai]
is_a: GO:0043426 ! MRF binding

[Term]
id: GO:0051580
name: regulation of neurotransmitter uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai]
synonym: "regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of neurotransmitter reuptake" EXACT []
is_a: GO:0050804 ! regulation of synaptic transmission
is_a: GO:0051588 ! regulation of neurotransmitter transport
relationship: regulates GO:0001504 ! neurotransmitter uptake

[Term]
id: GO:0051581
name: negative regulation of neurotransmitter uptake
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai]
synonym: "down regulation of neurotransmitter uptake" EXACT []
synonym: "down-regulation of neurotransmitter uptake" EXACT []
synonym: "downregulation of neurotransmitter uptake" EXACT []
synonym: "negative regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:0051589 ! negative regulation of neurotransmitter transport
relationship: negatively_regulates GO:0001504 ! neurotransmitter uptake

[Term]
id: GO:0051582
name: positive regulation of neurotransmitter uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai]
synonym: "activation of neurotransmitter uptake" NARROW []
synonym: "positive regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of neurotransmitter uptake" NARROW []
synonym: "up regulation of neurotransmitter uptake" EXACT []
synonym: "up-regulation of neurotransmitter uptake" EXACT []
synonym: "upregulation of neurotransmitter uptake" EXACT []
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:0051590 ! positive regulation of neurotransmitter transport
relationship: positively_regulates GO:0001504 ! neurotransmitter uptake

[Term]
id: GO:0051583
name: dopamine uptake
namespace: biological_process
def: "The directed movement of dopamine into a cell, typically presynaptic neurons or glial cells. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]
synonym: "dopamine import" EXACT [GOC:dph, GOC:tb]
synonym: "dopamine reuptake" EXACT []
is_a: GO:0015872 ! dopamine transport
is_a: GO:0051934 ! catecholamine uptake during transmission of nerve impulse
relationship: part_of GO:0001963 ! synaptic transmission, dopaminergic

[Term]
id: GO:0051584
name: regulation of dopamine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the catecholamine neurotransmitter dopamine into a cell." [GOC:ai]
synonym: "regulation of dopamine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic
is_a: GO:0051940 ! regulation of catecholamine uptake during transmission of nerve impulse
relationship: regulates GO:0051583 ! dopamine uptake

[Term]
id: GO:0051585
name: negative regulation of dopamine uptake
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of dopamine into a cell." [GOC:ai]
synonym: "down regulation of dopamine uptake" EXACT []
synonym: "down-regulation of dopamine uptake" EXACT []
synonym: "downregulation of dopamine uptake" EXACT []
synonym: "negative regulation of dopamine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051584 ! regulation of dopamine uptake
is_a: GO:0051945 ! negative regulation of catecholamine uptake during transmission of nerve impulse
relationship: negatively_regulates GO:0051583 ! dopamine uptake

[Term]
id: GO:0051586
name: positive regulation of dopamine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of dopamine into a cell." [GOC:ai]
synonym: "activation of dopamine uptake" NARROW []
synonym: "positive regulation of dopamine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of dopamine uptake" NARROW []
synonym: "up regulation of dopamine uptake" EXACT []
synonym: "up-regulation of dopamine uptake" EXACT []
synonym: "upregulation of dopamine uptake" EXACT []
is_a: GO:0051584 ! regulation of dopamine uptake
is_a: GO:0051944 ! positive regulation of catecholamine uptake during transmission of nerve impulse
relationship: positively_regulates GO:0051583 ! dopamine uptake

[Term]
id: GO:0051587
name: inhibition of dopamine uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of dopamine into a cell." [GOC:ai]
synonym: "inhibition of dopamine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051585 ! negative regulation of dopamine uptake
is_a: GO:0051609 ! inhibition of neurotransmitter uptake

[Term]
id: GO:0051588
name: regulation of neurotransmitter transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0006836 ! neurotransmitter transport

[Term]
id: GO:0051589
name: negative regulation of neurotransmitter transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of neurotransmitter transport" EXACT []
synonym: "down-regulation of neurotransmitter transport" EXACT []
synonym: "downregulation of neurotransmitter transport" EXACT []
synonym: "inhibition of neurotransmitter transport" NARROW []
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051588 ! regulation of neurotransmitter transport
relationship: negatively_regulates GO:0006836 ! neurotransmitter transport

[Term]
id: GO:0051590
name: positive regulation of neurotransmitter transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
synonym: "activation of neurotransmitter transport" NARROW []
synonym: "stimulation of neurotransmitter transport" NARROW []
synonym: "up regulation of neurotransmitter transport" EXACT []
synonym: "up-regulation of neurotransmitter transport" EXACT []
synonym: "upregulation of neurotransmitter transport" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051588 ! regulation of neurotransmitter transport
relationship: positively_regulates GO:0006836 ! neurotransmitter transport

[Term]
id: GO:0051591
name: response to cAMP
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:ai]
synonym: "response to 3',5' cAMP" EXACT []
synonym: "response to 3',5'-cAMP" EXACT []
synonym: "response to adenosine 3',5'-cyclophosphate" EXACT []
synonym: "response to cyclic AMP" EXACT []
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0051592
name: response to calcium ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai]
synonym: "response to Ca2+ ion" EXACT []
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0051593
name: response to folic acid
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:ai]
synonym: "cellular response to folate" EXACT [GOC:mah]
synonym: "cellular response to vitamin B9" EXACT [GOC:mah]
is_a: GO:0001101 ! response to acid
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0051594
name: detection of glucose
namespace: biological_process
def: "The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal." [GOC:ai]
synonym: "glucose detection" EXACT []
synonym: "glucose perception" RELATED []
synonym: "glucose sensing" RELATED []
is_a: GO:0009732 ! detection of hexose stimulus
is_a: GO:0009749 ! response to glucose stimulus

[Term]
id: GO:0051595
name: response to methylglyoxal
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus." [GOC:ai]
subset: gosubset_prok
synonym: "response to pyruvaldehyde" EXACT []
is_a: GO:0009636 ! response to toxin

[Term]
id: GO:0051596
name: methylglyoxal catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai]
subset: gosubset_prok
synonym: "methylglyoxal breakdown" EXACT []
synonym: "methylglyoxal catabolism" EXACT []
synonym: "methylglyoxal degradation" EXACT []
is_a: GO:0009438 ! methylglyoxal metabolic process
is_a: GO:0046185 ! aldehyde catabolic process

[Term]
id: GO:0051597
name: response to methylmercury
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus." [GOC:ai]
synonym: "response to CH3-Hg+" EXACT []
synonym: "response to MeHg+" EXACT []
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0051598
name: meiotic recombination checkpoint
namespace: biological_process
def: "A checkpoint during late prophase I (pachytene) which prevents segregation of homologous chromosomes until recombination is completed and ensures proper distribution of the genetic material to the gametes." [PMID:14718568]
synonym: "pachytene checkpoint" EXACT []
is_a: GO:0033313 ! meiotic cell cycle checkpoint
is_a: GO:0045835 ! negative regulation of meiosis
relationship: part_of GO:0007128 ! meiotic prophase I

[Term]
id: GO:0051599
name: response to hydrostatic pressure
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [Wikipedia:Hydrostatic_pressure]
synonym: "response to biomechanical stress" BROAD []
synonym: "response to static fluid pressure" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0009415 ! response to water

[Term]
id: GO:0051600
name: regulation of exocyst localization during endocytosis
namespace: biological_process
def: "Any process that modulates the localization of exocysts during endocytosis. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where secretory vesicles dock and fuse." [GOC:ai]
synonym: "regulation of site selection of endocytosis" RELATED []
synonym: "relocation of endocytosis" RELATED []
synonym: "spatial regulation of endocytosis" RELATED []
is_a: GO:0030100 ! regulation of endocytosis
is_a: GO:0060178 ! regulation of exocyst localization

[Term]
id: GO:0051601
name: exocyst localization
namespace: biological_process
def: "Any process by which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where secretory vesicles dock and fuse." [GOC:ai]
synonym: "establishment and maintenance of exocyst localization" EXACT []
is_a: GO:0034629 ! cellular protein complex localization

[Term]
id: GO:0051602
name: response to electrical stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus." [GOC:ai]
synonym: "response to electricity" RELATED []
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0051603
name: proteolysis involved in cellular protein catabolic process
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein during the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai]
subset: gosubset_prok
synonym: "peptidolysis during cellular protein catabolic process" EXACT []
synonym: "peptidolysis during cellular protein catabolism" EXACT []
synonym: "peptidolysis involved in cellular protein catabolic process" EXACT []
synonym: "peptidolysis involved in cellular protein catabolism" EXACT []
synonym: "proteolysis during cellular protein catabolic process" EXACT []
synonym: "proteolysis during cellular protein catabolism" EXACT []
is_a: GO:0006508 ! proteolysis
is_a: GO:0044257 ! cellular protein catabolic process

[Term]
id: GO:0051604
name: protein maturation
namespace: biological_process
def: "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0019538 ! protein metabolic process
relationship: part_of GO:0010467 ! gene expression

[Term]
id: GO:0051605
name: protein maturation by peptide bond cleavage
namespace: biological_process
def: "The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein." [GOC:ai, GOC:mah]
synonym: "peptidolysis during protein maturation" RELATED [GOC:mah]
synonym: "protein maturation by peptide bond hydrolysis" EXACT [GOC:mah]
synonym: "protein maturation by proteolysis" RELATED [GOC:mah]
is_a: GO:0006508 ! proteolysis
is_a: GO:0016485 ! protein processing

[Term]
id: GO:0051606
name: detection of stimulus
namespace: biological_process
def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah]
subset: goslim_pir
subset: gosubset_prok
synonym: "perception of stimulus" RELATED []
synonym: "stimulus detection" EXACT []
synonym: "stimulus sensing" RELATED []
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0051607
name: defense response to virus
namespace: biological_process
def: "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai]
synonym: "antiviral response" EXACT []
synonym: "defence response to virus" EXACT []
synonym: "defense response to viruses" EXACT []
is_a: GO:0002252 ! immune effector process
is_a: GO:0006952 ! defense response
is_a: GO:0009615 ! response to virus

[Term]
id: GO:0051608
name: histamine transport
namespace: biological_process
def: "The directed movement of histamine into, out of, within or between cells by means of some external agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai]
is_a: GO:0015837 ! amine transport

[Term]
id: GO:0051609
name: inhibition of neurotransmitter uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of a neurotransmitter into a cell." [GOC:ai]
synonym: "inhibition of neurotransmitter import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake

[Term]
id: GO:0051610
name: serotonin uptake
namespace: biological_process
def: "The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai]
synonym: "5-HT uptake" EXACT []
synonym: "5-hydroxytryptamine uptake" EXACT []
synonym: "5HT uptake" EXACT []
synonym: "serotonin import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001504 ! neurotransmitter uptake
is_a: GO:0006837 ! serotonin transport

[Term]
id: GO:0051611
name: regulation of serotonin uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the monoamine neurotransmitter serotonin into a cell." [GOC:ai]
synonym: "regulation of 5-HT uptake" EXACT []
synonym: "regulation of 5-hydroxytryptamine uptake" EXACT []
synonym: "regulation of 5HT uptake" EXACT []
synonym: "regulation of serotonin import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:0051952 ! regulation of amine transport
relationship: regulates GO:0051610 ! serotonin uptake

[Term]
id: GO:0051612
name: negative regulation of serotonin uptake
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of serotonin into a cell." [GOC:ai]
synonym: "down regulation of serotonin uptake" EXACT []
synonym: "down-regulation of serotonin uptake" EXACT []
synonym: "downregulation of serotonin uptake" EXACT []
synonym: "negative regulation of 5-HT uptake" EXACT []
synonym: "negative regulation of 5-hydroxytryptamine uptake" EXACT []
synonym: "negative regulation of 5HT uptake" EXACT []
synonym: "negative regulation of serotonin import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake
is_a: GO:0051611 ! regulation of serotonin uptake
is_a: GO:0051953 ! negative regulation of amine transport
relationship: negatively_regulates GO:0051610 ! serotonin uptake

[Term]
id: GO:0051613
name: positive regulation of serotonin uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of serotonin into a cell." [GOC:ai]
synonym: "activation of serotonin uptake" NARROW []
synonym: "positive regulation of 5-HT uptake" EXACT []
synonym: "positive regulation of 5-hydroxytryptamine uptake" EXACT []
synonym: "positive regulation of 5HT uptake" EXACT []
synonym: "positive regulation of serotonin import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of serotonin uptake" NARROW []
synonym: "up regulation of serotonin uptake" EXACT []
synonym: "up-regulation of serotonin uptake" EXACT []
synonym: "upregulation of serotonin uptake" EXACT []
is_a: GO:0051582 ! positive regulation of neurotransmitter uptake
is_a: GO:0051611 ! regulation of serotonin uptake
is_a: GO:0051954 ! positive regulation of amine transport
relationship: positively_regulates GO:0051610 ! serotonin uptake

[Term]
id: GO:0051614
name: inhibition of serotonin uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of serotonin into a cell." [GOC:ai]
synonym: "inhibition of 5-HT uptake" EXACT []
synonym: "inhibition of 5-hydroxytryptamine uptake" EXACT []
synonym: "inhibition of 5HT uptake" EXACT []
synonym: "inhibition of serotonin import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051609 ! inhibition of neurotransmitter uptake
is_a: GO:0051612 ! negative regulation of serotonin uptake

[Term]
id: GO:0051615
name: histamine uptake
namespace: biological_process
def: "The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai]
synonym: "histamine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001504 ! neurotransmitter uptake
is_a: GO:0051608 ! histamine transport

[Term]
id: GO:0051616
name: regulation of histamine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter histamine into a cell." [GOC:ai]
synonym: "regulation of histamine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:0051952 ! regulation of amine transport
relationship: regulates GO:0051615 ! histamine uptake

[Term]
id: GO:0051617
name: negative regulation of histamine uptake
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai]
synonym: "down regulation of histamine uptake" EXACT []
synonym: "down-regulation of histamine uptake" EXACT []
synonym: "downregulation of histamine uptake" EXACT []
synonym: "negative regulation of histamine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake
is_a: GO:0051616 ! regulation of histamine uptake
is_a: GO:0051953 ! negative regulation of amine transport
relationship: negatively_regulates GO:0051615 ! histamine uptake

[Term]
id: GO:0051618
name: positive regulation of histamine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai]
synonym: "activation of histamine uptake" NARROW []
synonym: "positive regulation of histamine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of histamine uptake" NARROW []
synonym: "up regulation of histamine uptake" EXACT []
synonym: "up-regulation of histamine uptake" EXACT []
synonym: "upregulation of histamine uptake" EXACT []
is_a: GO:0051582 ! positive regulation of neurotransmitter uptake
is_a: GO:0051616 ! regulation of histamine uptake
is_a: GO:0051954 ! positive regulation of amine transport
relationship: positively_regulates GO:0051615 ! histamine uptake

[Term]
id: GO:0051619
name: inhibition of histamine uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of histamine into a cell." [GOC:ai]
synonym: "inhibition of histamine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051609 ! inhibition of neurotransmitter uptake
is_a: GO:0051617 ! negative regulation of histamine uptake

[Term]
id: GO:0051620
name: norepinephrine uptake
namespace: biological_process
def: "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai]
synonym: "levarterenol reuptake" EXACT []
synonym: "levarterenol uptake" EXACT []
synonym: "noradrenaline reuptake" EXACT []
synonym: "noradrenaline uptake" EXACT []
synonym: "norepinephrine import" EXACT [GOC:dph, GOC:tb]
synonym: "norepinephrine reuptake" EXACT []
is_a: GO:0015874 ! norepinephrine transport
is_a: GO:0051934 ! catecholamine uptake during transmission of nerve impulse

[Term]
id: GO:0051621
name: regulation of norepinephrine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell." [GOC:ai]
synonym: "regulation of levarterenol uptake" EXACT []
synonym: "regulation of noradrenaline uptake" EXACT []
synonym: "regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051940 ! regulation of catecholamine uptake during transmission of nerve impulse
relationship: regulates GO:0051620 ! norepinephrine uptake

[Term]
id: GO:0051622
name: negative regulation of norepinephrine uptake
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai]
synonym: "down regulation of norepinephrine uptake" EXACT []
synonym: "down-regulation of norepinephrine uptake" EXACT []
synonym: "downregulation of norepinephrine uptake" EXACT []
synonym: "negative regulation of levarterenol uptake" EXACT []
synonym: "negative regulation of noradrenaline uptake" EXACT []
synonym: "negative regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051621 ! regulation of norepinephrine uptake
is_a: GO:0051945 ! negative regulation of catecholamine uptake during transmission of nerve impulse
relationship: negatively_regulates GO:0051620 ! norepinephrine uptake

[Term]
id: GO:0051623
name: positive regulation of norepinephrine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai]
synonym: "activation of norepinephrine uptake" NARROW []
synonym: "positive regulation of levarterenol uptake" EXACT []
synonym: "positive regulation of noradrenaline uptake" EXACT []
synonym: "positive regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of norepinephrine uptake" NARROW []
synonym: "up regulation of norepinephrine uptake" EXACT []
synonym: "up-regulation of norepinephrine uptake" EXACT []
synonym: "upregulation of norepinephrine uptake" EXACT []
is_a: GO:0051621 ! regulation of norepinephrine uptake
is_a: GO:0051944 ! positive regulation of catecholamine uptake during transmission of nerve impulse
relationship: positively_regulates GO:0051620 ! norepinephrine uptake

[Term]
id: GO:0051624
name: inhibition of norepinephrine uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of norepinephrine into a cell." [GOC:ai]
synonym: "inhibition of levarterenol uptake" EXACT []
synonym: "inhibition of noradrenaline uptake" EXACT []
synonym: "inhibition of norepinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051609 ! inhibition of neurotransmitter uptake
is_a: GO:0051622 ! negative regulation of norepinephrine uptake

[Term]
id: GO:0051625
name: epinephrine uptake
namespace: biological_process
def: "The directed movement of epinephrine into a cell, typically presynaptic neurons or glial cells. Epinephrine is a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:ai]
synonym: "adrenaline reuptake" EXACT []
synonym: "adrenaline uptake" EXACT []
synonym: "epinephrine import" EXACT [GOC:dph, GOC:tb]
synonym: "epinephrine reuptake" EXACT []
is_a: GO:0048241 ! epinephrine transport
is_a: GO:0051934 ! catecholamine uptake during transmission of nerve impulse

[Term]
id: GO:0051626
name: regulation of epinephrine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter epinephrine into a cell." [GOC:ai]
synonym: "regulation of adrenaline uptake" EXACT []
synonym: "regulation of epinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051940 ! regulation of catecholamine uptake during transmission of nerve impulse
relationship: regulates GO:0051625 ! epinephrine uptake

[Term]
id: GO:0051627
name: negative regulation of epinephrine uptake
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of epinephrine into a cell." [GOC:ai]
synonym: "down regulation of epinephrine uptake" EXACT []
synonym: "down-regulation of epinephrine uptake" EXACT []
synonym: "downregulation of epinephrine uptake" EXACT []
synonym: "negative regulation of adrenaline uptake" EXACT []
synonym: "negative regulation of epinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051626 ! regulation of epinephrine uptake
is_a: GO:0051945 ! negative regulation of catecholamine uptake during transmission of nerve impulse
relationship: negatively_regulates GO:0051625 ! epinephrine uptake

[Term]
id: GO:0051628
name: positive regulation of epinephrine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of epinephrine into a cell." [GOC:ai]
synonym: "activation of epinephrine uptake" NARROW []
synonym: "positive regulation of adrenaline uptake" EXACT []
synonym: "positive regulation of epinephrine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of epinephrine uptake" NARROW []
synonym: "up regulation of epinephrine uptake" EXACT []
synonym: "up-regulation of epinephrine uptake" EXACT []
synonym: "upregulation of epinephrine uptake" EXACT []
is_a: GO:0051626 ! regulation of epinephrine uptake
is_a: GO:0051944 ! positive regulation of catecholamine uptake during transmission of nerve impulse
relationship: positively_regulates GO:0051625 ! epinephrine uptake

[Term]
id: GO:0051629
name: inhibition of epinephrine uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of epinephrine into a cell." [GOC:ai]
synonym: "inhibition of adrenaline uptake" EXACT []
synonym: "inhibition of epinephrine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051609 ! inhibition of neurotransmitter uptake
is_a: GO:0051627 ! negative regulation of epinephrine uptake

[Term]
id: GO:0051630
name: acetylcholine uptake
namespace: biological_process
def: "The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:ai]
synonym: "acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001504 ! neurotransmitter uptake
is_a: GO:0015870 ! acetylcholine transport

[Term]
id: GO:0051631
name: regulation of acetylcholine uptake
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell." [GOC:ai]
synonym: "regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:0051952 ! regulation of amine transport
relationship: regulates GO:0051630 ! acetylcholine uptake

[Term]
id: GO:0051632
name: negative regulation of acetylcholine uptake
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai]
synonym: "down regulation of acetylcholine uptake" EXACT []
synonym: "down-regulation of acetylcholine uptake" EXACT []
synonym: "downregulation of acetylcholine uptake" EXACT []
synonym: "negative regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake
is_a: GO:0051631 ! regulation of acetylcholine uptake
is_a: GO:0051953 ! negative regulation of amine transport
relationship: negatively_regulates GO:0051630 ! acetylcholine uptake

[Term]
id: GO:0051633
name: positive regulation of acetylcholine uptake
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai]
synonym: "activation of acetylcholine uptake" NARROW []
synonym: "positive regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb]
synonym: "stimulation of acetylcholine uptake" NARROW []
synonym: "up regulation of acetylcholine uptake" EXACT []
synonym: "up-regulation of acetylcholine uptake" EXACT []
synonym: "upregulation of acetylcholine uptake" EXACT []
is_a: GO:0051582 ! positive regulation of neurotransmitter uptake
is_a: GO:0051631 ! regulation of acetylcholine uptake
is_a: GO:0051954 ! positive regulation of amine transport
relationship: positively_regulates GO:0051630 ! acetylcholine uptake

[Term]
id: GO:0051634
name: inhibition of acetylcholine uptake
namespace: biological_process
def: "Any process that prevents the activation of the directed movement of acetylcholine into a cell." [GOC:ai]
synonym: "inhibition of acetylcholine import" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051609 ! inhibition of neurotransmitter uptake
is_a: GO:0051632 ! negative regulation of acetylcholine uptake

[Term]
id: GO:0051635
name: bacterial cell surface binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any component on the surface of a bacterial cell." [GOC:ai]
subset: gosubset_prok
synonym: "bacterium cell surface binding" EXACT []
is_a: GO:0008367 ! bacterial binding
is_a: GO:0043498 ! cell surface binding

[Term]
id: GO:0051636
name: Gram-negative bacterial cell surface binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any component on the surface of a Gram-negative bacterial cell." [GOC:ai]
subset: gosubset_prok
synonym: "Gram-negative bacterium cell surface binding" EXACT []
is_a: GO:0008368 ! Gram-negative bacterial binding
is_a: GO:0051635 ! bacterial cell surface binding

[Term]
id: GO:0051637
name: Gram-positive bacterial cell surface binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any component on the surface of a Gram-positive bacterium." [GOC:ai]
subset: gosubset_prok
synonym: "Gram-positive bacterium cell surface binding" EXACT []
is_a: GO:0051076 ! Gram-positive bacterial binding
is_a: GO:0051635 ! bacterial cell surface binding

[Term]
id: GO:0051638
name: barbed-end actin filament uncapping
namespace: biological_process
def: "The removal of capping protein from the barbed (or plus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf]
synonym: "barbed end actin filament uncapping" EXACT []
synonym: "barbed end F-actin uncapping" EXACT []
synonym: "barbed-end F-actin uncapping" EXACT []
synonym: "plus end actin filament uncapping" EXACT []
synonym: "plus end F-actin uncapping" EXACT []
synonym: "plus-end actin filament uncapping" EXACT []
synonym: "plus-end F-actin uncapping" EXACT []
is_a: GO:0051695 ! actin filament uncapping

[Term]
id: GO:0051639
name: actin filament network formation
namespace: biological_process
def: "The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai]
synonym: "actin gel biosynthesis" EXACT []
synonym: "actin gel formation" EXACT []
is_a: GO:0007015 ! actin filament organization

[Term]
id: GO:0051640
name: organelle localization
namespace: biological_process
def: "Any process by which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai]
subset: goslim_pir
synonym: "establishment and maintenance of organelle localization" EXACT []
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0051641
name: cellular localization
namespace: biological_process
def: "Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "establishment and maintenance of cellular localization" EXACT []
synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT []
synonym: "intracellular localization" NARROW []
synonym: "localization within cell" NARROW []
is_a: GO:0009987 ! cellular process
is_a: GO:0051179 ! localization

[Term]
id: GO:0051642
name: centrosome localization
namespace: biological_process
def: "Any process by which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of centrosome localization" EXACT []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051643
name: ER localization
namespace: biological_process
def: "Any process by which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of ER localization" EXACT []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051644
name: plastid localization
namespace: biological_process
def: "Any process by which a plastid is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of plastid localization" EXACT []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051645
name: Golgi localization
namespace: biological_process
def: "Any process by which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of Golgi localization" EXACT []
synonym: "Golgi apparatus localization" EXACT []
synonym: "Golgi body localization" EXACT []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051646
name: mitochondrion localization
namespace: biological_process
def: "Any process by which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "establishment and maintenance of mitochondria localization" EXACT []
synonym: "establishment and maintenance of mitochondrion localization" EXACT []
synonym: "localization of mitochondria" EXACT []
synonym: "localization of mitochondrion" EXACT []
synonym: "mitochondria localization" EXACT []
synonym: "mitochondrial localization" EXACT []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051647
name: nucleus localization
namespace: biological_process
def: "Any process by which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
synonym: "cell nucleus localization" EXACT []
synonym: "establishment and maintenance of nucleus localization" EXACT []
synonym: "localization of nucleus" EXACT []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051648
name: vesicle localization
namespace: biological_process
def: "Any process by which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai]
synonym: "cytoplasmic vesicle localization" EXACT []
synonym: "establishment and maintenance of vesicle localization" EXACT []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051649
name: establishment of localization in cell
namespace: biological_process
def: "The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "establishment of cellular localization" RELATED [GOC:dph, GOC:tb]
synonym: "establishment of intracellular localization" NARROW []
synonym: "establishment of localization within cell" NARROW []
synonym: "positioning within cell" NARROW []
is_a: GO:0051234 ! establishment of localization
relationship: part_of GO:0051641 ! cellular localization

[Term]
id: GO:0051650
name: establishment of vesicle localization
namespace: biological_process
def: "The directed movement of a vesicle to a specific location." [GOC:ai]
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization
relationship: part_of GO:0051648 ! vesicle localization

[Term]
id: GO:0051651
name: maintenance of location in cell
namespace: biological_process
def: "Any process by which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai]
subset: gosubset_prok
synonym: "cellular retention" NARROW []
synonym: "cellular sequestering" NARROW []
synonym: "cellular storage" NARROW []
synonym: "intracellular retention" NARROW []
synonym: "intracellular sequestering" NARROW []
synonym: "intracellular storage" NARROW []
synonym: "maintenance of cellular localization" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of intracellular localization" NARROW []
synonym: "maintenance of localization in cell" RELATED [GOC:dph, GOC:tb]
synonym: "maintenance of localization within cell" NARROW []
synonym: "retention within cell" NARROW []
synonym: "sequestering within cell" NARROW []
synonym: "storage within cell" NARROW []
is_a: GO:0009987 ! cellular process
is_a: GO:0051235 ! maintenance of location
relationship: part_of GO:0051641 ! cellular localization

[Term]
id: GO:0051652
name: maintenance of chromosome location
namespace: biological_process
def: "Any process by which a chromosome is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of chromosome localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051657 ! maintenance of organelle location
relationship: part_of GO:0050000 ! chromosome localization

[Term]
id: GO:0051653
name: spindle localization
namespace: biological_process
def: "Any process by which is the spindle is transported to, and/or maintained in, a specific location." [GOC:ai]
synonym: "establishment and maintenance of spindle localization" EXACT []
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0051654
name: establishment of mitochondrion localization
namespace: biological_process
def: "The directed movement of the mitochondrion to a specific location." [GOC:ai]
synonym: "establishment of mitochondria localization" EXACT []
synonym: "mitochondria positioning" EXACT []
synonym: "mitochondrial migration" EXACT []
synonym: "mitochondrion positioning" EXACT []
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization
relationship: part_of GO:0051646 ! mitochondrion localization

[Term]
id: GO:0051655
name: maintenance of vesicle location
namespace: biological_process
def: "Any process by which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of vesicle localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051657 ! maintenance of organelle location
relationship: part_of GO:0051648 ! vesicle localization

[Term]
id: GO:0051656
name: establishment of organelle localization
namespace: biological_process
def: "The directed movement of an organelle to a specific location." [GOC:ai]
is_a: GO:0051234 ! establishment of localization
relationship: part_of GO:0051640 ! organelle localization

[Term]
id: GO:0051657
name: maintenance of organelle location
namespace: biological_process
def: "Any process by which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of organelle localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051651 ! maintenance of location in cell
relationship: part_of GO:0051640 ! organelle localization

[Term]
id: GO:0051658
name: maintenance of nucleus location
namespace: biological_process
def: "Any process by which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of cell nucleus location" EXACT []
synonym: "maintenance of nucleus localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051657 ! maintenance of organelle location
relationship: part_of GO:0051647 ! nucleus localization

[Term]
id: GO:0051659
name: maintenance of mitochondrion location
namespace: biological_process
def: "Any process by which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of mitochondria localization" EXACT []
synonym: "maintenance of mitochondrion localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051657 ! maintenance of organelle location
relationship: part_of GO:0051646 ! mitochondrion localization

[Term]
id: GO:0051660
name: establishment of centrosome localization
namespace: biological_process
def: "The directed movement of the centrosome to a specific location." [GOC:ai]
synonym: "centrosome positioning" EXACT []
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization
relationship: part_of GO:0051642 ! centrosome localization

[Term]
id: GO:0051661
name: maintenance of centrosome location
namespace: biological_process
def: "Any process by which a centrosome is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of centrosome localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051657 ! maintenance of organelle location
relationship: part_of GO:0051642 ! centrosome localization

[Term]
id: GO:0051663
name: oocyte nucleus localization involved in oocyte dorsal/ventral axis specification
namespace: biological_process
alt_id: GO:0051662
def: "The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte." [GOC:ai, GOC:dph, GOC:mtg_sensu, GOC:tb]
synonym: "establishment and maintenance of oocyte nucleus localization during oocyte axis determination" EXACT []
synonym: "oocyte axis determination, oocyte nucleus localization" EXACT []
synonym: "oocyte nucleus localization during oocyte axis determination" RELATED [GOC:dph, GOC:tb]
synonym: "oocyte nucleus localization involved in oocyte dorsal-ventral axis specification" EXACT [GOC:mah]
synonym: "oocyte nucleus localization involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb]
synonym: "oocyte nucleus localization involved in oocyte dorsoventral axis specification" EXACT [GOC:mah]
is_a: GO:0051647 ! nucleus localization
relationship: part_of GO:0007310 ! oocyte dorsal/ventral axis specification

[Term]
id: GO:0051664
name: nuclear pore localization
namespace: biological_process
def: "Any process by which nuclear pores are transported to, or maintained in, a specific location." [GOC:ai]
synonym: "establishment and maintenance of nuclear pore localization" EXACT []
is_a: GO:0034629 ! cellular protein complex localization
is_a: GO:0051668 ! localization within membrane

[Term]
id: GO:0051665
name: membrane raft localization
namespace: biological_process
def: "Any process by which membrane rafts are transported to, or maintained in, a specific location. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:ai, PMID:16645198]
synonym: "establishment and maintenance of membrane raft localization" EXACT []
synonym: "lipid raft localization" EXACT []
is_a: GO:0051668 ! localization within membrane

[Term]
id: GO:0051666
name: actin cortical patch localization
namespace: biological_process
def: "Any process by which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells." [GOC:mah]
synonym: "establishment and maintenance of actin cortical patch localization" EXACT []
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0051667
name: establishment of plastid localization
namespace: biological_process
def: "The directed movement of a plastid to a specific location in the cell." [GOC:ai]
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization
relationship: part_of GO:0051644 ! plastid localization

[Term]
id: GO:0051668
name: localization within membrane
namespace: biological_process
def: "Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai]
subset: gosubset_prok
synonym: "establishment and maintenance of localization in membrane" EXACT []
synonym: "establishment and maintenance of position in membrane" EXACT []
synonym: "localization to membrane" EXACT []
synonym: "positioning within membrane" NARROW []
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0051669
name: fructan beta-fructosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.80]
synonym: "beta-D-fructan fructohydrolase activity" EXACT [EC:3.2.1.80]
synonym: "exo-beta-D-fructosidase activity" EXACT []
synonym: "exo-beta-fructosidase activity" EXACT []
synonym: "fructan b-fructosidase activity" EXACT []
synonym: "fructan exohydrolase activity" EXACT []
synonym: "fructanase activity" EXACT [EC:3.2.1.80]
synonym: "polysaccharide beta-fructofuranosidase activity" EXACT []
xref: EC:3.2.1.80
xref: MetaCyc:3.2.1.80-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0051670
name: inulinase activity
namespace: molecular_function
def: "Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin." [EC:3.2.1.7]
synonym: "2,1-beta-D-fructan fructanohydrolase activity" EXACT []
synonym: "endo-inulinase activity" EXACT []
synonym: "exoinulinase activity" EXACT []
synonym: "indoinulinase activity" EXACT []
synonym: "inulase activity" EXACT []
xref: EC:3.2.1.7
xref: MetaCyc:3.2.1.7-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0051671
name: induction of autolysin activity in another organism
namespace: biological_process
def: "Any process by which an organism initiates the activity of the inactive enzyme autolysin in another organism. The autolysin enzyme belongs to, and is active in, the other organism." [GOC:ai]
subset: gosubset_prok
synonym: "activation of autolysin activity in another organism" EXACT []
synonym: "activation of autolysis in other organism" NARROW []
synonym: "activation of autolytic activity in other organism" NARROW []
synonym: "induction of autolysis in other organism" NARROW []
synonym: "induction of autolytic activity in other organism" NARROW []
synonym: "positive regulation of autolysin activity in another organism" BROAD []
is_a: GO:0043946 ! positive regulation of catalytic activity in other organism during symbiotic interaction

[Term]
id: GO:0051672
name: catabolism by organism of cell wall peptidoglycan in other organism
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the cell wall peptidoglycans of another organism." [GOC:ai]
subset: gosubset_prok
synonym: "catabolic process of cell wall peptidoglycans of other organism" EXACT []
synonym: "catabolism of cell wall peptidoglycans of other organism" EXACT []
synonym: "cell wall catabolic process in other organism" NARROW []
synonym: "cell wall catabolism in other organism" NARROW []
synonym: "cell wall peptidoglycan catabolic process in another organism" EXACT []
is_a: GO:0009253 ! peptidoglycan catabolic process
is_a: GO:0016998 ! cell wall macromolecule catabolic process
relationship: part_of GO:0009617 ! response to bacterium
relationship: part_of GO:0044278 ! cell wall disassembly in other organism

[Term]
id: GO:0051673
name: membrane disruption in another organism
namespace: biological_process
def: "The disruption of the membranes of another organism, leading to damage to its cells and possibly death of that organism." [GOC:ai]
subset: gosubset_prok
synonym: "cytolysis, by membrane disruption, in other organism" NARROW []
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0051674
name: localization of cell
namespace: biological_process
def: "Any process by which a cell is transported to, and/or maintained in, a specific location." [GOC:ai]
subset: gosubset_prok
synonym: "cell localization" EXACT []
synonym: "establishment and maintenance of cell localization" EXACT []
synonym: "establishment and maintenance of localization of cell" EXACT []
is_a: GO:0051179 ! localization

[Term]
id: GO:0051675
name: isopullulanase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose)." [EC:3.2.1.57]
synonym: "pullulan 4-glucanohydrolase (isopanose-forming) activity" EXACT []
xref: EC:3.2.1.57
xref: MetaCyc:3.2.1.57-RXN
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds

[Term]
id: GO:0051676
name: pullulan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [PMID:15013381]
synonym: "pullulan metabolism" EXACT []
is_a: GO:0006073 ! cellular glucan metabolic process

[Term]
id: GO:0051677
name: pullulan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [GOC:ai]
is_a: GO:0009250 ! glucan biosynthetic process
is_a: GO:0051676 ! pullulan metabolic process

[Term]
id: GO:0051678
name: pullulan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [GOC:ai]
is_a: GO:0009251 ! glucan catabolic process
is_a: GO:0044247 ! cellular polysaccharide catabolic process
is_a: GO:0051676 ! pullulan metabolic process

[Term]
id: GO:0051679
name: 6-alpha-maltosylglucose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai, LIGAND:C03367, PubChem:439991]
synonym: "6-alpha-maltosylglucose metabolism" EXACT []
synonym: "isopanose metabolic process" EXACT []
synonym: "isopanose metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0051680
name: 6-alpha-maltosylglucose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai]
synonym: "isopanose biosynthesis" EXACT []
synonym: "isopanose biosynthetic process" EXACT []
is_a: GO:0009312 ! oligosaccharide biosynthetic process
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0051679 ! 6-alpha-maltosylglucose metabolic process

[Term]
id: GO:0051681
name: 6-alpha-maltosylglucose catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai]
synonym: "isopanose catabolic process" EXACT []
synonym: "isopanose catabolism" EXACT []
is_a: GO:0044247 ! cellular polysaccharide catabolic process
is_a: GO:0051679 ! 6-alpha-maltosylglucose metabolic process

[Term]
id: GO:0051682
name: galactomannan catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units." [GOC:ai]
is_a: GO:0046355 ! mannan catabolic process
is_a: GO:0051069 ! galactomannan metabolic process

[Term]
id: GO:0051683
name: establishment of Golgi localization
namespace: biological_process
def: "The directed movement of the Golgi to a specific location." [GOC:ai]
synonym: "establishment of Golgi apparatus localization" EXACT []
synonym: "establishment of Golgi body localization" EXACT []
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization
relationship: part_of GO:0051645 ! Golgi localization

[Term]
id: GO:0051684
name: maintenance of Golgi location
namespace: biological_process
def: "Any process by which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of Golgi apparatus localization" EXACT []
synonym: "maintenance of Golgi body localization" EXACT []
synonym: "maintenance of Golgi localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051657 ! maintenance of organelle location
relationship: part_of GO:0051645 ! Golgi localization

[Term]
id: GO:0051685
name: maintenance of ER location
namespace: biological_process
def: "Any process by which the endoplasmic reticulum is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of endoplasmic reticulum localization" EXACT []
synonym: "maintenance of ER localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051657 ! maintenance of organelle location
relationship: part_of GO:0051643 ! ER localization

[Term]
id: GO:0051686
name: establishment of ER localization
namespace: biological_process
def: "The directed movement of the endoplasmic reticulum to a specific location." [GOC:ai]
synonym: "establishment of endoplasmic reticulum localization" EXACT []
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0051656 ! establishment of organelle localization
relationship: part_of GO:0051643 ! ER localization

[Term]
id: GO:0051687
name: maintenance of spindle location
namespace: biological_process
def: "Any process by which the spindle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of spindle localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051657 ! maintenance of organelle location
relationship: part_of GO:0051653 ! spindle localization

[Term]
id: GO:0051688
name: maintenance of plastid location
namespace: biological_process
def: "Any process by which a plastid is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of plastid localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051657 ! maintenance of organelle location
relationship: part_of GO:0051644 ! plastid localization

[Term]
id: GO:0051689
name: multicellular organismal oligosaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, in multicellular organisms, occurring at the tissue, organ, or organismal level." [GOC:ai]
synonym: "organismal oligosaccharide breakdown" EXACT []
synonym: "organismal oligosaccharide catabolism" EXACT []
synonym: "organismal oligosaccharide degradation" EXACT []
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:0044276 ! multicellular organismal carbohydrate catabolic process
is_a: GO:0051690 ! multicellular organismal oligosaccharide metabolic process

[Term]
id: GO:0051690
name: multicellular organismal oligosaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, in multicellular organisms, occurring at the tissue, organ, or organismal level." [GOC:ai]
synonym: "organismal oligosaccharide metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0044261 ! multicellular organismal carbohydrate metabolic process

[Term]
id: GO:0051691
name: cellular oligosaccharide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells." [GOC:ai]
synonym: "cellular oligosaccharide metabolism" EXACT []
is_a: GO:0009311 ! oligosaccharide metabolic process
is_a: GO:0044262 ! cellular carbohydrate metabolic process

[Term]
id: GO:0051692
name: cellular oligosaccharide catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells." [GOC:ai]
synonym: "cellular oligosaccharide breakdown" EXACT []
synonym: "cellular oligosaccharide catabolism" EXACT []
synonym: "cellular oligosaccharide degradation" EXACT []
is_a: GO:0009313 ! oligosaccharide catabolic process
is_a: GO:0044275 ! cellular carbohydrate catabolic process
is_a: GO:0051691 ! cellular oligosaccharide metabolic process

[Term]
id: GO:0051693
name: actin filament capping
namespace: biological_process
def: "The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]
synonym: "actin capping activity" RELATED []
synonym: "F-actin capping activity" RELATED []
is_a: GO:0030835 ! negative regulation of actin filament depolymerization
is_a: GO:0030837 ! negative regulation of actin filament polymerization

[Term]
id: GO:0051694
name: pointed-end actin filament capping
namespace: biological_process
def: "The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]
synonym: "minus-end actin filament capping activity" EXACT []
synonym: "minus-end F-actin capping activity" EXACT []
synonym: "pointed-end actin capping activity" EXACT []
synonym: "pointed-end F-actin capping activity" EXACT []
is_a: GO:0051693 ! actin filament capping

[Term]
id: GO:0051695
name: actin filament uncapping
namespace: biological_process
def: "The removal of capping protein from the end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf]
synonym: "F-actin uncapping" EXACT []
is_a: GO:0030836 ! positive regulation of actin filament depolymerization

[Term]
id: GO:0051696
name: pointed-end actin filament uncapping
namespace: biological_process
def: "The removal of capping protein from the pointed (or minus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf]
synonym: "minus end actin filament uncapping" EXACT []
synonym: "minus end F-actin uncapping" EXACT []
synonym: "minus-end actin filament uncapping" EXACT []
synonym: "minus-end F-actin uncapping" EXACT []
synonym: "pointed end actin filament uncapping" EXACT []
synonym: "pointed end F-actin uncapping" EXACT []
synonym: "pointed-end F-actin uncapping" EXACT []
is_a: GO:0051695 ! actin filament uncapping

[Term]
id: GO:0051697
name: protein delipidation
namespace: biological_process
def: "The breakage of covalent or non-covalent bonds to detach lipid moieties from a protein." [GOC:ai]
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0051698
name: saccharopine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-saccharopine + O2 = L-2-aminoadipic 6-semialdehyde + L-glutamate + H2O2." [PMID:16233628]
synonym: "SAX activity" BROAD []
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0051699
name: proline oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2." [MetaCyc:RXN-821]
xref: EC:1.5.3.-
xref: MetaCyc:RXN-821
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0051700
name: fructosyl-amino acid oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: fructosyl-amino acid + O2 = corresponding amino acid + glucosone + H2O2." [PMID:16233628]
synonym: "FAOD activity" EXACT []
xref: EC:1.5.3.-
is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

[Term]
id: GO:0051701
name: interaction with host
namespace: biological_process
def: "An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044419 ! interspecies interaction between organisms
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051702
name: interaction with symbiont
namespace: biological_process
def: "An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc]
subset: gosubset_prok
is_a: GO:0044419 ! interspecies interaction between organisms
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051703
name: intraspecies interaction between organisms
namespace: biological_process
def: "Any process by which an organism has an effect on an organism of the same species." [GOC:ai]
subset: goslim_pir
subset: gosubset_prok
synonym: "intraspecies interaction with other organisms" EXACT []
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0051704
name: multi-organism process
namespace: biological_process
alt_id: GO:0051706
def: "Any process by which an organism has an effect on another organism of the same or different species." [GOC:ai]
subset: goslim_goa
subset: goslim_pir
subset: gosubset_prok
synonym: "interaction between organisms" EXACT []
synonym: "physiological interaction between organisms" EXACT []
synonym: "physiological interaction with other organism" EXACT []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0051705
name: behavioral interaction between organisms
namespace: biological_process
def: "Any process by which an organism has a behavioral effect on another organism of the same or different species." [GOC:ai]
subset: goslim_pir
synonym: "behavioral interaction with other organism" EXACT []
synonym: "behavioural interaction between organisms" EXACT []
synonym: "behavioural interaction with other organism" EXACT []
is_a: GO:0007610 ! behavior
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0051707
name: response to other organism
namespace: biological_process
alt_id: GO:0009613
alt_id: GO:0042828
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai]
subset: gosubset_prok
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0051704 ! multi-organism process

[Term]
id: GO:0051708
name: intracellular protein transport in other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of an organism's proteins within a cell of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0006886 ! intracellular protein transport
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051709
name: regulation of killing of cells of another organism
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai]
subset: gosubset_prok
is_a: GO:0031341 ! regulation of cell killing
is_a: GO:0043900 ! regulation of multi-organism process
relationship: regulates GO:0031640 ! killing of cells of another organism

[Term]
id: GO:0051710
name: regulation of cytolysis of cells of another organism
namespace: biological_process
alt_id: GO:0001902
def: "Any process that modulates the frequency, rate or extent of the cytolysis by an organism of cells in another organism." [GOC:ai]
subset: gosubset_prok
synonym: "regulation of cytolysis of cells of another, non-host, organism" NARROW []
is_a: GO:0051709 ! regulation of killing of cells of another organism
relationship: regulates GO:0051715 ! cytolysis of cells of another organism

[Term]
id: GO:0051711
name: negative regulation of killing of cells of another organism
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of killing of cells of another organism" EXACT []
synonym: "down-regulation of killing of cells of another organism" EXACT []
synonym: "downregulation of killing of cells of another organism" EXACT []
synonym: "inhibition of killing of cells of another organism" NARROW []
is_a: GO:0031342 ! negative regulation of cell killing
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0051709 ! regulation of killing of cells of another organism
relationship: negatively_regulates GO:0031640 ! killing of cells of another organism

[Term]
id: GO:0051712
name: positive regulation of killing of cells of another organism
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai]
subset: gosubset_prok
synonym: "activation of killing of cells of another organism" NARROW []
synonym: "stimulation of killing of cells of another organism" NARROW []
synonym: "up regulation of killing of cells of another organism" EXACT []
synonym: "up-regulation of killing of cells of another organism" EXACT []
synonym: "upregulation of killing of cells of another organism" EXACT []
is_a: GO:0031343 ! positive regulation of cell killing
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0051709 ! regulation of killing of cells of another organism
relationship: positively_regulates GO:0031640 ! killing of cells of another organism

[Term]
id: GO:0051713
name: negative regulation of cytolysis of cells of another organism
namespace: biological_process
alt_id: GO:0001903
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the cytolysis of cells in another organism." [GOC:ai]
subset: gosubset_prok
synonym: "down regulation of cytolysis of cells of another organism" EXACT []
synonym: "down-regulation of cytolysis of cells of another organism" EXACT []
synonym: "downregulation of cytolysis of cells of another organism" EXACT []
synonym: "inhibition of cytolysis of cells of another organism" NARROW []
synonym: "negative regulation of cytolysis of cells of another, non-host, organism" NARROW []
is_a: GO:0051710 ! regulation of cytolysis of cells of another organism
is_a: GO:0051711 ! negative regulation of killing of cells of another organism
relationship: negatively_regulates GO:0051715 ! cytolysis of cells of another organism

[Term]
id: GO:0051714
name: positive regulation of cytolysis of cells of another organism
namespace: biological_process
alt_id: GO:0001904
def: "Any process that activates or increases the frequency, rate or extent of the cytolysis by an organism of cells in another organism." [GOC:ai]
subset: gosubset_prok
synonym: "activation of cytolysis of cells of another organism" NARROW []
synonym: "positive regulation of cytolysis of cells of another, non-host, organism" NARROW []
synonym: "stimulation of cytolysis of cells of another organism" NARROW []
synonym: "up regulation of cytolysis of cells of another organism" EXACT []
synonym: "up-regulation of cytolysis of cells of another organism" EXACT []
synonym: "upregulation of cytolysis of cells of another organism" EXACT []
is_a: GO:0051710 ! regulation of cytolysis of cells of another organism
is_a: GO:0051712 ! positive regulation of killing of cells of another organism
relationship: positively_regulates GO:0051715 ! cytolysis of cells of another organism

[Term]
id: GO:0051715
name: cytolysis of cells of another organism
namespace: biological_process
alt_id: GO:0001901
def: "The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm." [GOC:ai]
subset: gosubset_prok
synonym: "cytolysis of cells of another, non-host, organism" NARROW []
synonym: "cytolysis of cells of competing organism" NARROW []
is_a: GO:0031640 ! killing of cells of another organism

[Term]
id: GO:0051716
name: cellular response to stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jl]
subset: gosubset_prok
is_a: GO:0009987 ! cellular process
is_a: GO:0050896 ! response to stimulus

[Term]
id: GO:0051717
name: inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:bf, MetaCyc:3.1.3.62-RXN]
synonym: "inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity" EXACT [EC:2.7.1.-]
synonym: "inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity" EXACT [EC:2.7.1.-]
synonym: "inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity" EXACT [EC:2.7.1.-]
xref: MetaCyc:3.1.3.62-RXN
is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity

[Term]
id: GO:0051718
name: DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpG." [EC:2.1.1.37, PMID:15689527]
synonym: "HpaII methylase" NARROW [EC:2.1.1.37]
synonym: "HpaII' methylase" NARROW [EC:2.1.1.37]
synonym: "M.BsuRIa" NARROW [EC:2.1.1.37]
synonym: "M.BsuRIb" NARROW [EC:2.1.1.37]
is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity

[Term]
id: GO:0051719
name: DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN." [EC:2.1.1.37, PMID:15689527]
is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity

[Term]
id: GO:0051720
name: DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG." [EC:2.1.1.37, PMID:15689527]
is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity

[Term]
id: GO:0051721
name: protein phosphatase 2A binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 2A." [GOC:ai]
is_a: GO:0019903 ! protein phosphatase binding

[Term]
id: GO:0051722
name: protein C-terminal methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol." [PMID:10318862, PMID:8650216]
synonym: "protein phosphatase methylesterase activity" NARROW []
is_a: GO:0051723 ! protein methylesterase activity

[Term]
id: GO:0051723
name: protein methylesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol." [GOC:ai]
subset: gosubset_prok
synonym: "PME activity" EXACT [EC:2.7.1.-]
synonym: "protein carboxyl methylesterase activity" EXACT [EC:2.7.1.-]
synonym: "protein carboxylic ester hydrolase activity" EXACT []
synonym: "protein methyl-esterase activity" EXACT [EC:2.7.1.-]
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0051724
name: NAD transporter activity
namespace: molecular_function
def: "Enables the directed movement of nicotinamide adenine dinucleotide into, out of, within or between cells; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:ai]
synonym: "NAD (oxidized) transporter activity" EXACT []
synonym: "NAD (reduced) transporter activity" EXACT []
synonym: "NAD+ transporter activity" EXACT []
synonym: "NADH transporter activity" EXACT []
synonym: "nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT []
synonym: "oxidized NAD transporter activity" EXACT []
synonym: "oxidized nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT []
synonym: "reduced NAD transporter activity" EXACT []
synonym: "reduced nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT []
is_a: GO:0051184 ! cofactor transporter activity

[Term]
id: GO:0051725
name: protein amino acid de-ADP-ribosylation
namespace: biological_process
def: "The process of removing one or more ADP-ribose residues from a protein." [GOC:ai]
synonym: "poly(ADP-ribose) removal from protein" EXACT []
synonym: "protein poly(ADP-ribose) catabolic process" EXACT []
synonym: "protein poly(ADP-ribose) catabolism" EXACT []
synonym: "protein poly(ADP-ribose) degradation" EXACT []
synonym: "protein poly(ADP-ribose) hydrolysis" EXACT []
synonym: "removal of ADP-ribose from protein" EXACT []
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0051726
name: regulation of cell cycle
namespace: biological_process
alt_id: GO:0000074
def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb]
subset: gosubset_prok
synonym: "cell cycle control" EXACT []
synonym: "cell cycle modulation" EXACT []
synonym: "cell cycle regulation" EXACT []
synonym: "cell cycle regulator" RELATED []
synonym: "control of cell cycle progression" EXACT []
synonym: "modulation of cell cycle progression" EXACT []
synonym: "regulation of cell cycle progression" EXACT []
synonym: "regulation of progression through cell cycle" EXACT []
synonym: "tumor suppressor" RELATED []
xref: Reactome:156678 "Activation of Cdc25C"
xref: Reactome:156699 "Inactivation of Wee1 kinase"
xref: Reactome:156711 "Polo-like kinase mediated events"
xref: Reactome:162657 "Inactivation of Myt1 kinase"
xref: Reactome:429000 "Activation of Cdc25C"
xref: Reactome:440597 "Inactivation of Myt1 kinase"
xref: Reactome:440632 "Inactivation of Wee1 kinase"
xref: Reactome:448691 "Polo-like kinase mediated events"
xref: Reactome:451327 "Activation of Cdc25C"
xref: Reactome:462379 "Inactivation of Myt1 kinase"
xref: Reactome:462418 "Inactivation of Wee1 kinase"
xref: Reactome:469816 "Polo-like kinase mediated events"
xref: Reactome:481114 "Inactivation of Myt1 kinase"
xref: Reactome:481147 "Inactivation of Wee1 kinase"
xref: Reactome:487948 "Polo-like kinase mediated events"
xref: Reactome:501179 "Inactivation of Myt1 kinase"
xref: Reactome:501212 "Inactivation of Wee1 kinase"
xref: Reactome:507919 "Polo-like kinase mediated events"
xref: Reactome:514352 "Inactivation of Myt1 kinase"
xref: Reactome:514372 "Inactivation of Wee1 kinase"
xref: Reactome:517799 "Polo-like kinase mediated events"
xref: Reactome:523399 "Inactivation of Myt1 kinase"
xref: Reactome:523416 "Inactivation of Wee1 kinase"
xref: Reactome:526632 "Polo-like kinase mediated events"
xref: Reactome:529710 "Inactivation of Myt1 kinase"
xref: Reactome:529716 "Inactivation of Wee1 kinase"
xref: Reactome:531433 "Polo-like kinase mediated events"
xref: Reactome:534968 "Inactivation of Myt1 kinase"
xref: Reactome:534973 "Inactivation of Wee1 kinase"
xref: Reactome:536805 "Polo-like kinase mediated events"
xref: Reactome:540566 "Inactivation of Myt1 kinase"
xref: Reactome:540581 "Inactivation of Wee1 kinase"
xref: Reactome:542564 "Polo-like kinase mediated events"
xref: Reactome:546191 "Inactivation of Myt1 kinase"
xref: Reactome:546209 "Inactivation of Wee1 kinase"
xref: Reactome:547884 "Polo-like kinase mediated events"
xref: Reactome:550927 "Inactivation of Myt1 kinase"
xref: Reactome:550949 "Inactivation of Wee1 kinase"
xref: Reactome:552461 "Polo-like kinase mediated events"
xref: Reactome:556130 "Inactivation of Myt1 kinase"
xref: Reactome:556150 "Inactivation of Wee1 kinase"
xref: Reactome:558068 "Polo-like kinase mediated events"
xref: Reactome:590491 "Inactivation of Myt1 kinase"
xref: Reactome:590501 "Inactivation of Wee1 kinase"
xref: Reactome:592813 "Polo-like kinase mediated events"
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0007049 ! cell cycle

[Term]
id: GO:0051727
name: cell cycle switching, meiotic to mitotic cell cycle
namespace: biological_process
def: "The process by which a cell switches cell cycle mode from meiotic to mitotic division." [GOC:ai]
synonym: "cell cycle switching, meiosis to mitosis" NARROW []
synonym: "conversion to mitosis" NARROW []
synonym: "conversion to mitotic cell cycle" EXACT []
synonym: "entry into mitosis" NARROW []
synonym: "entry into mitotic cell cycle" EXACT []
synonym: "initiation of mitosis" NARROW []
synonym: "initiation of mitotic cell cycle" EXACT []
synonym: "mitotic entry" NARROW []
is_a: GO:0060184 ! cell cycle switching

[Term]
id: GO:0051728
name: cell cycle switching, mitotic to meiotic cell cycle
namespace: biological_process
alt_id: GO:0042061
def: "The process by which a cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai]
synonym: "cell cycle switching, mitotis to meiosis" NARROW []
synonym: "conversion to meiosis" NARROW []
synonym: "conversion to meiotic cell cycle" EXACT []
synonym: "entry into meiosis" NARROW []
synonym: "entry into meiotic cell cycle" EXACT []
synonym: "initiation of meiosis" NARROW []
synonym: "initiation of meiotic cell cycle" EXACT []
synonym: "meiotic entry" NARROW []
is_a: GO:0060184 ! cell cycle switching

[Term]
id: GO:0051729
name: germline cell cycle switching, mitotic to meiotic cell cycle
namespace: biological_process
def: "The process by which a germline cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai]
synonym: "germline cell cycle switching, mitotis to meiosis" NARROW []
synonym: "germline conversion to meiosis" NARROW []
synonym: "germline conversion to meiotic cell cycle" EXACT []
synonym: "germline entry into meiosis" NARROW []
synonym: "germline entry into meiotic cell cycle" EXACT []
synonym: "germline initiation of meiosis" NARROW []
synonym: "germline initiation of meiotic cell cycle" EXACT []
synonym: "germline meiotic entry" NARROW []
is_a: GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle

[Term]
id: GO:0051730
name: GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA." [EC:2.7.1.78, PMID:8428918]
synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD []
synonym: "GTP-dependent polyribonucleotide kinase activity" EXACT []
synonym: "GTP-dependent RNA 5'-hydroxyl-kinase activity" EXACT []
synonym: "GTP-dependent RNA kinase activity" EXACT []
synonym: "GTP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity" EXACT []
is_a: GO:0051732 ! polyribonucleotide kinase activity
is_a: GO:0051735 ! GTP-dependent polynucleotide kinase activity

[Term]
id: GO:0051731
name: polynucleotide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78]
synonym: "5'-dephosphopolynucleotide kinase activity" EXACT []
synonym: "5'-hydroxyl polynucleotide kinase activity" EXACT [EC:2.7.1.78]
synonym: "PNK" RELATED [EC:2.7.1.78]
synonym: "polynucleotide 5'-hydroxy-kinase activity" EXACT [EC:2.7.1.78]
synonym: "polynucleotide 5'-hydroxyl kinase (phosphorylating) activity" EXACT [EC:2.7.1.78]
synonym: "polynucleotide 5'-hydroxyl-kinase activity" EXACT [EC:2.7.1.78]
xref: EC:2.7.1.-
xref: MetaCyc:POLYNUCLEOTIDE-5-HYDROXYL-KINASE-RXN
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor
is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity

[Term]
id: GO:0051732
name: polyribonucleotide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + 5'-dephospho-RNA = NDP + 5'-phospho-RNA." [EC:2.7.1.78]
synonym: "5'-hydroxyl polyribonucleotide kinase activity" EXACT [EC:2.7.1.78]
synonym: "5'-hydroxyl RNA kinase activity" EXACT [EC:2.7.1.78]
synonym: "RNA 5'-hydroxyl kinase activity" EXACT []
synonym: "RNA kinase activity" EXACT []
is_a: GO:0051731 ! polynucleotide kinase activity

[Term]
id: GO:0051733
name: polydeoxyribonucleotide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA." [EC:2.7.1.78]
synonym: "DNA 5'-hydroxyl kinase activity" EXACT []
synonym: "DNA kinase activity" EXACT []
is_a: GO:0051731 ! polynucleotide kinase activity

[Term]
id: GO:0051734
name: ATP-dependent polynucleotide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78]
synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" EXACT []
synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphatase activity" EXACT [EC:2.7.1.78]
synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphotransferase activity" EXACT []
xref: EC:2.7.1.-
is_a: GO:0051731 ! polynucleotide kinase activity

[Term]
id: GO:0051735
name: GTP-dependent polynucleotide kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 5'-dephosphopolynucleotide = GDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [EC:2.7.1.78]
synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" EXACT []
synonym: "GTP:5'-dephosphopolynucleotide 5'-phosphotransferase activity" EXACT []
xref: EC:2.7.1.-
is_a: GO:0051731 ! polynucleotide kinase activity

[Term]
id: GO:0051736
name: ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA." [EC:2.7.1.78]
synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD []
synonym: "ATP-dependent polyribonucleotide kinase activity" EXACT []
synonym: "ATP-dependent RNA 5'-hydroxyl-kinase activity" EXACT []
synonym: "ATP-dependent RNA kinase activity" EXACT []
synonym: "ATP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity" EXACT []
is_a: GO:0051732 ! polyribonucleotide kinase activity
is_a: GO:0051734 ! ATP-dependent polynucleotide kinase activity

[Term]
id: GO:0051737
name: GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + 5'-dephospho-DNA = GDP + 5'-phospho-DNA." [EC:2.7.1.78, PMID:8428918]
synonym: "GTP-dependent DNA 5'-hydroxyl-kinase activity" EXACT []
synonym: "GTP-dependent DNA kinase activity" EXACT []
synonym: "GTP-dependent polydeoxyribonucleotide kinase activity" EXACT []
synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD []
synonym: "GTP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity" EXACT []
is_a: GO:0051733 ! polydeoxyribonucleotide kinase activity
is_a: GO:0051735 ! GTP-dependent polynucleotide kinase activity

[Term]
id: GO:0051738
name: xanthophyll binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen." [ISBN:0122146743]
is_a: GO:0019840 ! isoprenoid binding
is_a: GO:0031409 ! pigment binding

[Term]
id: GO:0051739
name: ammonia transmembrane transporter activity
namespace: molecular_function
def: "Enables the directed movement of ammonia from one side of the membrane to the other." [GOC:go_curators]
subset: gosubset_prok
is_a: GO:0022891 ! substrate-specific transmembrane transporter activity

[Term]
id: GO:0051740
name: ethylene binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:ai]
synonym: "ethene binding" EXACT []
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0051741
name: 2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2542]
synonym: "MPBQ methyltransferase activity" EXACT []
xref: MetaCyc:RXN-2542
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0051742
name: 2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2762]
synonym: "MSBQ methyltransferase activity" EXACT []
xref: MetaCyc:RXN-2762
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0051743
name: red chlorophyll catabolite reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: red chlorophyll catabolite (RCC) + reduced ferredoxin + 2 H+ = primary fluorescent catabolite (pFCC) + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite to a colorless tetrapyrrole with a strong blue fluorescence." [PMID:10743659]
synonym: "RCC reductase activity" EXACT []
xref: EC:1.3.7.-
xref: MetaCyc:RXN-7741
is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor

[Term]
id: GO:0051744
name: 3,8-divinyl protochlorophyllide a 8-vinyl reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+." [MetaCyc:RXN1F-72]
xref: MetaCyc:RXN1F-72
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0051745
name: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+ = isopentenyl diphosphate + NAD(P)+ + H2O. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate." [EC:1.17.1.2]
synonym: "4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity" EXACT [EC:1.17.1.2]
synonym: "isopentenyl-diphosphate:NAD(P)+ oxidoreductase activity" EXACT []
xref: EC:1.17.1.2
xref: MetaCyc:ISPH2-RXN
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0051746
name: thalianol synthase activity
namespace: molecular_function
def: "Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol)." [PMID:15125655]
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0051747
name: DNA demethylase activity
namespace: molecular_function
def: "Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA." [PMID:10050851]
is_a: GO:0016787 ! hydrolase activity
is_a: GO:0032451 ! demethylase activity

[Term]
id: GO:0051748
name: UTP-monosaccharide-1-phosphate uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide." [EC:2.7.7.64, PMID:15326166]
subset: gosubset_prok
synonym: "PsUSP" RELATED [EC:2.7.7.64]
synonym: "UDP-monosaccharide diphosphorylase activity" EXACT []
synonym: "UDP-monosaccharide pyrophosphorylase activity" EXACT []
synonym: "UDP-sugar pyrophosphorylase activity" EXACT [EC:2.7.7.64]
synonym: "USP" RELATED [EC:2.7.7.64]
xref: EC:2.7.7.64
xref: MetaCyc:2.7.7.64-RXN
is_a: GO:0070569 ! uridylyltransferase activity

[Term]
id: GO:0051749
name: indole acetic acid carboxyl methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine." [PMID:16169896]
synonym: "IAA carboxyl methyltransferase activity" EXACT []
is_a: GO:0008168 ! methyltransferase activity

[Term]
id: GO:0051750
name: delta3,5-delta2,4-dienoyl-CoA isomerase activity
namespace: molecular_function
def: "Catalysis of the isomerization of 3,5-dienoyl-CoA to 2,4-dienoyl-CoA." [PMID:16040662]
is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds

[Term]
id: GO:0051751
name: alpha-1,4-mannosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,4-linkage." [PMID:15772281]
is_a: GO:0000030 ! mannosyltransferase activity

[Term]
id: GO:0051752
name: phosphoglucan, water dikinase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [phospho-alpha-glucan] + H2O = AMP + O-phospho-[phospho-alpha-glucan] + phosphate." [EC:2.7.9.5, PMID:15618411]
synonym: "ATP:phospho-alpha-glucan, water phosphotransferase activity" EXACT [EC:2.7.9.5]
synonym: "OK1" RELATED [EC:2.7.9.5]
synonym: "PWD" RELATED [EC:2.7.9.5]
xref: EC:2.7.9.5
xref: MetaCyc:2.7.9.5-RXN
is_a: GO:0016301 ! kinase activity
is_a: GO:0016781 ! phosphotransferase activity, paired acceptors

[Term]
id: GO:0051753
name: mannan synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: mannan(n) + GDP-mannose = mannan(n+1) + GDP. This reaction is the formation of the beta-1,4-linked mannan backbone in substrates such as galactomannan." [PMID:14726589]
synonym: "galactomannan beta-1,4-mannosyltransferase activity" NARROW []
synonym: "mannan beta-1,4-mannosyltransferase activity" EXACT []
is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity

[Term]
id: GO:0051754
name: meiotic sister chromatid cohesion, centromeric
namespace: biological_process
def: "The cell cycle process whereby centromeres of sister chromatids are joined during meiosis." [PMID:14730319, PMID:16325576]
synonym: "meiotic sister chromatid cohesion at centromere" EXACT []
synonym: "sister chromatid cohesion at centromere at meiosis I" EXACT []
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion

[Term]
id: GO:0051755
name: meiotic sister chromatid arm separation
namespace: biological_process
def: "The cell cycle process whereby sister chromatid arms are physically detached from each other during meiosis." [GOC:ai]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0007127 ! meiosis I
relationship: part_of GO:0051757 ! meiotic sister chromatid separation

[Term]
id: GO:0051756
name: meiotic sister chromatid centromere separation
namespace: biological_process
def: "The cell cycle process whereby the centromeres of sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576]
is_a: GO:0034510 ! centromere separation
relationship: part_of GO:0045144 ! meiotic sister chromatid segregation
relationship: part_of GO:0051757 ! meiotic sister chromatid separation

[Term]
id: GO:0051757
name: meiotic sister chromatid separation
namespace: biological_process
def: "The process by which sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576]
is_a: GO:0051307 ! meiotic chromosome separation

[Term]
id: GO:0051758
name: homologous chromosome movement towards spindle pole during meiosis I
namespace: biological_process
def: "The directed movement of homologous chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis I." [GOC:ai]
synonym: "meiosis I, homologous chromosome movement towards spindle pole" EXACT []
is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole
relationship: part_of GO:0045143 ! homologous chromosome segregation

[Term]
id: GO:0051759
name: sister chromosome movement towards spindle pole during meiosis II
namespace: biological_process
def: "The directed movement of sister chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis II." [GOC:ai]
synonym: "meiosis II, sister chromosome movement towards spindle pole" EXACT []
is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole
relationship: part_of GO:0045144 ! meiotic sister chromatid segregation

[Term]
id: GO:0051760
name: meiotic sister chromatid cohesion, arms
namespace: biological_process
def: "The cell cycle process whereby the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during meiosis." [PMID:14730319, PMID:16325576]
synonym: "meiotic sister chromatid cohesion along arms" EXACT []
synonym: "sister chromatid cohesion along arms at meiosis I" EXACT []
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion

[Term]
id: GO:0051761
name: sesquiterpene metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai]
subset: gosubset_prok
synonym: "sesquiterpene metabolism" EXACT []
is_a: GO:0042214 ! terpene metabolic process

[Term]
id: GO:0051762
name: sesquiterpene biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai]
subset: gosubset_prok
is_a: GO:0046246 ! terpene biosynthetic process
is_a: GO:0051761 ! sesquiterpene metabolic process

[Term]
id: GO:0051763
name: sesquiterpene catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai]
subset: gosubset_prok
is_a: GO:0046247 ! terpene catabolic process
is_a: GO:0051761 ! sesquiterpene metabolic process

[Term]
id: GO:0051764
name: actin crosslink formation
namespace: biological_process
def: "The process by which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes." [GOC:ai]
comment: See also the molecular function term 'protein binding, bridging ; GO:0030674'.
synonym: "actin bundling" RELATED []
synonym: "actin crosslinking" EXACT []
synonym: "bridging actin filaments" NARROW []
synonym: "formation of actin crosslink" EXACT []
is_a: GO:0007015 ! actin filament organization

[Term]
id: GO:0051765
name: inositol tetrakisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP." [GOC:ai]
is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0051766
name: inositol trisphosphate kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP." [GOC:ai]
is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity
is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor

[Term]
id: GO:0051767
name: nitric-oxide synthase biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39, GOC:ai]
synonym: "NO synthase biosynthesis" EXACT []
synonym: "NO synthase biosynthetic process" EXACT []
synonym: "NOS biosynthesis" EXACT []
synonym: "NOS biosynthetic process" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0051768
name: nitric-oxide synthase 2 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nitric-oxide synthase 2, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [GOC:ai]
synonym: "nitric-oxide synthase (type 2) biosynthesis" EXACT []
synonym: "nitric-oxide synthase (type 2) biosynthetic process" EXACT []
synonym: "nitric-oxide synthase (type II) biosynthesis" EXACT []
synonym: "nitric-oxide synthase (type II) biosynthetic process" EXACT []
synonym: "NOS2 synthase biosynthesis" EXACT []
synonym: "NOS2 synthase biosynthetic process" EXACT []
is_a: GO:0009059 ! macromolecule biosynthetic process

[Term]
id: GO:0051769
name: regulation of nitric-oxide synthase biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase." [GOC:ai]
synonym: "regulation of NO synthase biosynthesis" EXACT []
synonym: "regulation of NO synthase biosynthetic process" EXACT []
synonym: "regulation of NOS biosynthesis" EXACT []
synonym: "regulation of NOS biosynthetic process" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
relationship: regulates GO:0051767 ! nitric-oxide synthase biosynthetic process

[Term]
id: GO:0051770
name: positive regulation of nitric-oxide synthase biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric oxide synthase." [GOC:ai]
synonym: "activation of nitric-oxide synthase biosynthetic process" NARROW []
synonym: "positive regulation of NO synthase biosynthesis" EXACT []
synonym: "positive regulation of NO synthase biosynthetic process" EXACT []
synonym: "positive regulation of NOS biosynthesis" EXACT []
synonym: "positive regulation of NOS biosynthetic process" EXACT []
synonym: "stimulation of nitric-oxide synthase biosynthetic process" NARROW []
synonym: "up regulation of nitric-oxide synthase biosynthetic process" EXACT []
synonym: "up-regulation of nitric-oxide synthase biosynthetic process" EXACT []
synonym: "upregulation of nitric-oxide synthase biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0051769 ! regulation of nitric-oxide synthase biosynthetic process
relationship: positively_regulates GO:0051767 ! nitric-oxide synthase biosynthetic process

[Term]
id: GO:0051771
name: negative regulation of nitric-oxide synthase biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase." [GOC:ai]
synonym: "down regulation of nitric-oxide synthase biosynthetic process" EXACT []
synonym: "down-regulation of nitric-oxide synthase biosynthetic process" EXACT []
synonym: "downregulation of nitric-oxide synthase biosynthetic process" EXACT []
synonym: "inhibition of nitric-oxide synthase biosynthetic process" NARROW []
synonym: "negative regulation of NO synthase biosynthesis" EXACT []
synonym: "negative regulation of NO synthase biosynthetic process" EXACT []
synonym: "negative regulation of NOS biosynthesis" EXACT []
synonym: "negative regulation of NOS biosynthetic process" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0051769 ! regulation of nitric-oxide synthase biosynthetic process
relationship: negatively_regulates GO:0051767 ! nitric-oxide synthase biosynthetic process

[Term]
id: GO:0051772
name: regulation of nitric-oxide synthase 2 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase 2." [GOC:ai]
synonym: "regulation of nitric-oxide synthase (type 2) biosynthesis" EXACT []
synonym: "regulation of nitric-oxide synthase (type 2) biosynthetic process" EXACT []
synonym: "regulation of nitric-oxide synthase (type II) biosynthesis" EXACT []
synonym: "regulation of nitric-oxide synthase (type II) biosynthetic process" EXACT []
synonym: "regulation of NOS2 synthase biosynthesis" EXACT []
synonym: "regulation of NOS2 synthase biosynthetic process" EXACT []
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
relationship: regulates GO:0051768 ! nitric-oxide synthase 2 biosynthetic process

[Term]
id: GO:0051773
name: positive regulation of nitric-oxide synthase 2 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric oxide synthase 2." [GOC:ai]
synonym: "activation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "positive regulation of nitric-oxide synthase (type 2) biosynthesis" EXACT []
synonym: "positive regulation of nitric-oxide synthase (type 2) biosynthetic process" EXACT []
synonym: "positive regulation of nitric-oxide synthase (type II) biosynthesis" EXACT []
synonym: "positive regulation of nitric-oxide synthase (type II) biosynthetic process" EXACT []
synonym: "positive regulation of NOS2 synthase biosynthesis" EXACT []
synonym: "positive regulation of NOS2 synthase biosynthetic process" EXACT []
synonym: "stimulation of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "up regulation of nitric-oxide synthase 2 biosynthetic process" EXACT []
synonym: "up-regulation of nitric-oxide synthase 2 biosynthetic process" EXACT []
synonym: "upregulation of nitric-oxide synthase 2 biosynthetic process" EXACT []
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0051772 ! regulation of nitric-oxide synthase 2 biosynthetic process
relationship: positively_regulates GO:0051768 ! nitric-oxide synthase 2 biosynthetic process

[Term]
id: GO:0051774
name: negative regulation of nitric-oxide synthase 2 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme nitric-oxide synthase 2." [GOC:ai]
synonym: "down regulation of nitric-oxide synthase 2 biosynthetic process" EXACT []
synonym: "down-regulation of nitric-oxide synthase 2 biosynthetic process" EXACT []
synonym: "downregulation of nitric-oxide synthase 2 biosynthetic process" EXACT []
synonym: "inhibition of nitric-oxide synthase 2 biosynthetic process" NARROW []
synonym: "negative regulation of nitric-oxide synthase (type 2) biosynthesis" EXACT []
synonym: "negative regulation of nitric-oxide synthase (type 2) biosynthetic process" EXACT []
synonym: "negative regulation of nitric-oxide synthase (type II) biosynthesis" EXACT []
synonym: "negative regulation of nitric-oxide synthase (type II) biosynthetic process" EXACT []
synonym: "negative regulation of NOS2 synthase biosynthesis" EXACT []
synonym: "negative regulation of NOS2 synthase biosynthetic process" EXACT []
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0051772 ! regulation of nitric-oxide synthase 2 biosynthetic process
relationship: negatively_regulates GO:0051768 ! nitric-oxide synthase 2 biosynthetic process

[Term]
id: GO:0051775
name: response to redox state
namespace: biological_process
alt_id: GO:0006980
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah, PMID:15131240, PMID:16987039]
subset: gosubset_prok
synonym: "redox signal response" EXACT []
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0051776
name: detection of redox state
namespace: biological_process
def: "The series of events in which a chemical stimulus indicating redox state is received and converted into a molecular signal. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah, PMID:15131240, PMID:16987039]
synonym: "redox sensing" EXACT []
is_a: GO:0009593 ! detection of chemical stimulus
is_a: GO:0051775 ! response to redox state

[Term]
id: GO:0051777
name: ent-kaurenoate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-kaurenoate + NADPH + O2 = ent-7-alpha-hydroxykaurenoate + NADP+ + H2O. This is the first of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-159]
comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'.
synonym: "ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating) activity" EXACT [EC:1.14.13.79]
synonym: "ent-kaurenoic acid oxidase activity" EXACT []
xref: MetaCyc:1.14.13.79-RXN
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0051778
name: ent-7-alpha-hydroxykaurenoate oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-160]
comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'.
xref: MetaCyc:RXN1F-160
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0051779
name: gibberellin 12-aldehyde oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: gibberellin 12-aldehyde + NADPH + O2 = gibberellin 12 (GA12) + NADP+ + H2O. This is the third of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-161]
comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778'.
synonym: "GA12-aldehyde oxidase activity" EXACT []
xref: MetaCyc:RXN1F-161
is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0051780
name: behavioral response to nutrient
namespace: biological_process
def: "A change in the behavior of an organism as a result of a nutrient stimulus." [GOC:ai]
synonym: "behavioural response to nutrient" EXACT []
is_a: GO:0007584 ! response to nutrient

[Term]
id: GO:0051781
name: positive regulation of cell division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai]
synonym: "activation of cell division" NARROW []
synonym: "stimulation of cell division" NARROW []
synonym: "up regulation of cell division" EXACT []
synonym: "up-regulation of cell division" EXACT []
synonym: "upregulation of cell division" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051302 ! regulation of cell division
relationship: positively_regulates GO:0051301 ! cell division

[Term]
id: GO:0051782
name: negative regulation of cell division
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell division." [GOC:ai]
synonym: "down regulation of cell division" EXACT []
synonym: "down-regulation of cell division" EXACT []
synonym: "downregulation of cell division" EXACT []
synonym: "inhibition of cell division" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051302 ! regulation of cell division
relationship: negatively_regulates GO:0051301 ! cell division

[Term]
id: GO:0051783
name: regulation of nuclear division
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0000280 ! nuclear division

[Term]
id: GO:0051784
name: negative regulation of nuclear division
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai]
synonym: "down regulation of nuclear division" EXACT []
synonym: "down-regulation of nuclear division" EXACT []
synonym: "downregulation of nuclear division" EXACT []
synonym: "inhibition of nuclear division" NARROW []
is_a: GO:0010639 ! negative regulation of organelle organization
is_a: GO:0051783 ! regulation of nuclear division
relationship: negatively_regulates GO:0000280 ! nuclear division

[Term]
id: GO:0051785
name: positive regulation of nuclear division
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai]
synonym: "activation of nuclear division" NARROW []
synonym: "stimulation of nuclear division" NARROW []
synonym: "up regulation of nuclear division" EXACT []
synonym: "up-regulation of nuclear division" EXACT []
synonym: "upregulation of nuclear division" EXACT []
is_a: GO:0010638 ! positive regulation of organelle organization
is_a: GO:0051783 ! regulation of nuclear division
relationship: positively_regulates GO:0000280 ! nuclear division

[Term]
id: GO:0051786
name: all-trans-retinol 13,14-reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: all-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor. Note that this reaction has only been observed to occur in the opposite direction." [EC:1.3.99.23]
synonym: "(13,14)-all-trans-retinol saturase activity" EXACT []
synonym: "all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase activity" EXACT []
synonym: "all-trans-retinol:all-trans-13,14-dihydroretinol saturase activity" EXACT []
synonym: "retinol saturase activity" EXACT [EC:1.3.99.23]
synonym: "RetSat activity" EXACT [EC:1.3.99.23]
xref: EC:1.3.99.23
xref: MetaCyc:1.3.99.23-RXN
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0051787
name: misfolded protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a misfolded protein." [GOC:ai]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0051788
name: response to misfolded protein
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:go_curators]
is_a: GO:0006950 ! response to stress
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0051789 ! response to protein stimulus

[Term]
id: GO:0051789
name: response to protein stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus." [GOC:ai]
subset: gosubset_prok
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0051790
name: short-chain fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of less than 8 carbons." [GOC:go_curators]
synonym: "short chain fatty acid biosynthesis" EXACT []
synonym: "short chain fatty acid biosynthetic process" EXACT []
synonym: "short-chain fatty acid anabolism" EXACT []
synonym: "short-chain fatty acid biosynthesis" EXACT []
synonym: "short-chain fatty acid formation" EXACT []
synonym: "short-chain fatty acid synthesis" EXACT []
is_a: GO:0006633 ! fatty acid biosynthetic process
is_a: GO:0046459 ! short-chain fatty acid metabolic process

[Term]
id: GO:0051791
name: medium-chain fatty acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving medium-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C8-12." [GOC:go_curators]
synonym: "medium chain fatty acid metabolic process" EXACT []
synonym: "medium chain fatty acid metabolism" EXACT []
synonym: "medium-chain fatty acid metabolism" EXACT []
is_a: GO:0006631 ! fatty acid metabolic process

[Term]
id: GO:0051792
name: medium-chain fatty acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of between 8 and 12 carbons." [GOC:ai]
synonym: "medium chain fatty acid biosynthesis" EXACT []
synonym: "medium chain fatty acid biosynthetic process" EXACT []
synonym: "medium-chain fatty acid anabolism" EXACT []
synonym: "medium-chain fatty acid biosynthesis" EXACT []
synonym: "medium-chain fatty acid formation" EXACT []
synonym: "medium-chain fatty acid synthesis" EXACT []
is_a: GO:0051791 ! medium-chain fatty acid metabolic process

[Term]
id: GO:0051793
name: medium-chain fatty acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of between 8 and 12 carbons." [GOC:ai]
synonym: "medium chain fatty acid catabolic process" EXACT []
synonym: "medium chain fatty acid catabolism" EXACT []
synonym: "medium-chain fatty acid breakdown" EXACT []
synonym: "medium-chain fatty acid catabolism" EXACT []
synonym: "medium-chain fatty acid degradation" EXACT []
is_a: GO:0051791 ! medium-chain fatty acid metabolic process

[Term]
id: GO:0051794
name: regulation of catagen
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of catagen, the regression phase of the hair cycle." [GOC:ai]
is_a: GO:0048819 ! regulation of hair follicle maturation
relationship: regulates GO:0042637 ! catagen

[Term]
id: GO:0051795
name: positive regulation of catagen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of catagen, the regression phase of the hair cycle." [GOC:ai]
synonym: "activation of catagen" NARROW []
synonym: "stimulation of catagen" NARROW []
synonym: "up regulation of catagen" EXACT []
synonym: "up-regulation of catagen" EXACT []
synonym: "upregulation of catagen" EXACT []
is_a: GO:0048818 ! positive regulation of hair follicle maturation
is_a: GO:0051794 ! regulation of catagen
relationship: positively_regulates GO:0042637 ! catagen

[Term]
id: GO:0051796
name: negative regulation of catagen
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of catagen, the regression phase of the hair cycle." [GOC:ai]
synonym: "down regulation of catagen" EXACT []
synonym: "down-regulation of catagen" EXACT []
synonym: "downregulation of catagen" EXACT []
synonym: "inhibition of catagen" NARROW []
is_a: GO:0048817 ! negative regulation of hair follicle maturation
is_a: GO:0051794 ! regulation of catagen
relationship: negatively_regulates GO:0042637 ! catagen

[Term]
id: GO:0051797
name: regulation of hair follicle development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hair follicle development." [GOC:ai]
is_a: GO:0042634 ! regulation of hair cycle
is_a: GO:0045682 ! regulation of epidermis development
relationship: regulates GO:0001942 ! hair follicle development

[Term]
id: GO:0051798
name: positive regulation of hair follicle development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of hair follicle development." [GOC:ai]
synonym: "activation of hair follicle development" NARROW []
synonym: "stimulation of hair follicle development" NARROW []
synonym: "up regulation of hair follicle development" EXACT []
synonym: "up-regulation of hair follicle development" EXACT []
synonym: "upregulation of hair follicle development" EXACT []
is_a: GO:0045684 ! positive regulation of epidermis development
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0051797 ! regulation of hair follicle development
relationship: positively_regulates GO:0001942 ! hair follicle development

[Term]
id: GO:0051799
name: negative regulation of hair follicle development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of hair follicle development." [GOC:ai]
synonym: "down regulation of hair follicle development" EXACT []
synonym: "down-regulation of hair follicle development" EXACT []
synonym: "downregulation of hair follicle development" EXACT []
synonym: "inhibition of hair follicle development" NARROW []
is_a: GO:0045683 ! negative regulation of epidermis development
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0051797 ! regulation of hair follicle development
relationship: negatively_regulates GO:0001942 ! hair follicle development

[Term]
id: GO:0051800
name: phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidyl inositol-4-phosphate + phosphate." [GOC:bf, PMID:9811831]
synonym: "PTEN activity" BROAD []
is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity
is_a: GO:0042577 ! lipid phosphatase activity

[Term]
id: GO:0051801
name: cytolysis of cells in other organism during symbiotic interaction
namespace: biological_process
def: "The killing by an organism of a cell in a second organism by means of the rupture of cell membranes and the loss of cytoplasm, where the two organisms are in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
is_a: GO:0051715 ! cytolysis of cells of another organism
is_a: GO:0051883 ! killing of cells in other organism during symbiotic interaction

[Term]
id: GO:0051802
name: regulation of cytolysis of cells in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
is_a: GO:0051710 ! regulation of cytolysis of cells of another organism
relationship: regulates GO:0051801 ! cytolysis of cells in other organism during symbiotic interaction

[Term]
id: GO:0051803
name: negative regulation of cytolysis of cells in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
synonym: "down regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT []
synonym: "down-regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT []
synonym: "downregulation of cytolysis of cells in other organism during symbiotic interaction" EXACT []
synonym: "inhibition of cytolysis of cells in other organism during symbiotic interaction" NARROW []
is_a: GO:0051713 ! negative regulation of cytolysis of cells of another organism
is_a: GO:0051802 ! regulation of cytolysis of cells in other organism during symbiotic interaction
relationship: negatively_regulates GO:0051801 ! cytolysis of cells in other organism during symbiotic interaction

[Term]
id: GO:0051804
name: positive regulation of cytolysis of cells in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
synonym: "activation of cytolysis of cells in other organism during symbiotic interaction" NARROW []
synonym: "stimulation of cytolysis of cells in other organism during symbiotic interaction" NARROW []
synonym: "up regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT []
synonym: "upregulation of cytolysis of cells in other organism during symbiotic interaction" EXACT []
is_a: GO:0051714 ! positive regulation of cytolysis of cells of another organism
is_a: GO:0051802 ! regulation of cytolysis of cells in other organism during symbiotic interaction
relationship: positively_regulates GO:0051801 ! cytolysis of cells in other organism during symbiotic interaction

[Term]
id: GO:0051805
name: evasion or tolerance of immune response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism avoids the immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mb]
subset: gosubset_prok
synonym: "immune evasion" EXACT []
is_a: GO:0051807 ! evasion or tolerance of defense response of other organism during symbiotic interaction
is_a: GO:0052564 ! response to immune response of other organism during symbiotic interaction

[Term]
id: GO:0051806
name: entry into cell of other organism during symbiotic interaction
namespace: biological_process
def: "The invasion by an organism of a cell of a second organism, where the two organisms are in a symbiotic interaction." [GOC:njm]
subset: gosubset_prok
synonym: "other organism cell invasion" EXACT []
is_a: GO:0051828 ! entry into other organism during symbiotic interaction

[Term]
id: GO:0051807
name: evasion or tolerance of defense response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of a second organism's defense response; the defense response is mounted by the second organism in response to the presence of the first organism, where the two organisms are in a symbiotic interaction." [GOC:mah]
subset: gosubset_prok
synonym: "evasion of other organism defence response" EXACT []
is_a: GO:0006952 ! defense response
is_a: GO:0051834 ! evasion or tolerance of defenses of other organism during symbiotic interaction

[Term]
id: GO:0051808
name: translocation of peptides or proteins into other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of peptides or proteins produced by an organism to a location inside a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "transport of peptides or proteins into other organism during symbiotic interaction" EXACT []
is_a: GO:0015031 ! protein transport
is_a: GO:0051836 ! translocation of molecules into other organism during symbiotic interaction

[Term]
id: GO:0051809
name: passive evasion of immune response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism avoids the immune response of a second organism without directly interfering with the second organism's immune system, where the two organisms are in a symbiotic interaction." [PMID:12439615]
subset: gosubset_prok
synonym: "passive immune evasion" EXACT []
is_a: GO:0051805 ! evasion or tolerance of immune response of other organism during symbiotic interaction

[Term]
id: GO:0051810
name: active evasion of immune response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism avoids the immune response of a second organism which directly affects the second organism's immune system, where the two organisms are in a symbiotic interaction." [PMID:12439615]
subset: gosubset_prok
synonym: "active immune evasion" EXACT []
is_a: GO:0051805 ! evasion or tolerance of immune response of other organism during symbiotic interaction

[Term]
id: GO:0051811
name: active evasion of immune response of other organism via regulation of complement system of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism avoids the immune response of a second organism by regulating the second organism's complement system, where the two organisms are in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html]
synonym: "active immune evasion via modulation of complement system of other organism" EXACT []
synonym: "active immune evasion via regulation of complement system of other organism" EXACT []
is_a: GO:0051810 ! active evasion of immune response of other organism during symbiotic interaction

[Term]
id: GO:0051812
name: active evasion of immune response of other organism via regulation of cytokine network of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism avoids the immune response of a second organism by regulating the second organism's cytokine networks, where the two organisms are in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation]
synonym: "active immune evasion via modulation of cytokine network of other organism" EXACT []
synonym: "active immune evasion via regulation of cytokine network of other organism" EXACT []
is_a: GO:0051810 ! active evasion of immune response of other organism during symbiotic interaction

[Term]
id: GO:0051813
name: active evasion of immune response of other organism via regulation of antigen processing and presentation in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism avoids the immune response of a second organism by regulating the second organism's antigen processing or presentation pathways, where the two organisms are in a symbiotic interaction." [PMID:12439615]
synonym: "active evasion of immune response of other organism via regulation of antigen processing and presentation pathway in other organism during symbiotic interaction" EXACT []
synonym: "active immune evasion via modulation of antigen processing and presentation in other organism" EXACT []
synonym: "active immune evasion via modulation of antigen processing/presentation in other organism" EXACT []
synonym: "active immune evasion via regulation of antigen processing and presentation in other organism" EXACT []
is_a: GO:0042786 ! active evasion of host immune response via regulation of host antigen processing and presentation

[Term]
id: GO:0051814
name: movement in other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism or its progeny spreads from one location to another within a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "movement within other organism during symbiotic interaction" EXACT []
is_a: GO:0052192 ! movement in environment of other organism during symbiotic interaction

[Term]
id: GO:0051815
name: migration in other organism during symbiotic interaction
namespace: biological_process
def: "The directional movement of an organism from one place to another within a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "migration within other organism during symbiotic interaction" EXACT []
is_a: GO:0051814 ! movement in other organism during symbiotic interaction

[Term]
id: GO:0051816
name: acquisition of nutrients from other organism during symbiotic interaction
namespace: biological_process
def: "The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0007631 ! feeding behavior
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051817
name: modification of morphology or physiology of other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism effects a change in the structure or processes of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "modulation of morphology or physiology of other organism during symbiotic interaction" EXACT []
synonym: "regulation of morphology of other organism" NARROW []
synonym: "regulation of morphology or physiology of other organism during symbiotic interaction" EXACT []
synonym: "regulation of physiological process in other organism" NARROW []
synonym: "regulation of physiology of other organism" NARROW []
is_a: GO:0065008 ! regulation of biological quality
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051818
name: disruption of cells of other organism during symbiotic interaction
namespace: biological_process
def: "A process by which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction

[Term]
id: GO:0051819
name: induction of tumor, nodule, or growth in other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism causes the formation of an abnormal mass of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction

[Term]
id: GO:0051820
name: induction of tumor, nodule, or growth containing transformed cells in other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism causes the formation in a second organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
is_a: GO:0051819 ! induction of tumor, nodule, or growth in other organism during symbiotic interaction

[Term]
id: GO:0051821
name: dissemination or transmission of organism from other organism during symbiotic interaction
namespace: biological_process
def: "The movement of an organism from a second organism to another place in the environment, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism." [GOC:cc]
subset: gosubset_prok
is_a: GO:0040011 ! locomotion
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051822
name: dissemination or transmission of organism from other organism by vector during symbiotic interaction
namespace: biological_process
def: "The movement of an organism from a second organism to another place in the environment by means of a vector, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism, and the vector organism is often an insect or an animal." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051821 ! dissemination or transmission of organism from other organism during symbiotic interaction

[Term]
id: GO:0051823
name: regulation of synapse structural plasticity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane." [PMID:11063967, PMID:14976517, PMID:9884123]
synonym: "regulation of synaptic structural plasticity" EXACT []
is_a: GO:0050807 ! regulation of synapse organization

[Term]
id: GO:0051824
name: recognition of other organism during symbiotic interaction
namespace: biological_process
def: "The set of specific processes that allow an organism to detect the presence of a second organism via physical or chemical signals, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0009595 ! detection of biotic stimulus
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051825
name: adhesion to other organism during symbiotic interaction
namespace: biological_process
def: "The attachment of an organism to a second organism, where the two organisms are in a symbiotic interaction. Adhesion may be via adhesion molecules, general stickiness etc., and may be either direct or indirect." [GOC:cc]
subset: gosubset_prok
is_a: GO:0022610 ! biological adhesion
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051826
name: negative regulation of synapse structural plasticity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse structural plasticity." [GOC:ai]
synonym: "down regulation of synapse structural plasticity" EXACT []
synonym: "down-regulation of synapse structural plasticity" EXACT []
synonym: "downregulation of synapse structural plasticity" EXACT []
synonym: "inhibition of synapse structural plasticity" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051823 ! regulation of synapse structural plasticity

[Term]
id: GO:0051827
name: growth or development on or near surface of other organism during symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth on or near surface of other organism during symbiotic interaction ; GO:0044153' and 'development on or near surface of other organism during symbiotic interaction ; GO:0044152'.
subset: gosubset_prok
is_obsolete: true
replaced_by: GO:0044152
replaced_by: GO:0044153

[Term]
id: GO:0051828
name: entry into other organism during symbiotic interaction
namespace: biological_process
def: "Penetration by an organism into the body, tissues, or cells of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "invasion into other organism" EXACT []
synonym: "invasion of other organism" EXACT []
synonym: "invasive growth" RELATED []
synonym: "other organism invasion" EXACT []
is_a: GO:0052192 ! movement in environment of other organism during symbiotic interaction

[Term]
id: GO:0051829
name: entry into other organism through natural portals during symbiotic interaction
namespace: biological_process
def: "Penetration by an organism into a second organism via naturally occurring openings in the second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051828 ! entry into other organism during symbiotic interaction

[Term]
id: GO:0051830
name: entry into other organism through barriers of other organism during symbiotic interaction
namespace: biological_process
def: "Penetration by an organism into a second organism via active breaching of physical barriers, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051828 ! entry into other organism during symbiotic interaction

[Term]
id: GO:0051831
name: growth or development in other organism during symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GOC:cc]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth in other organism during symbiotic interaction ; GO:0044112' and 'development in other organism during symbiotic interaction ; GO:0044113'.
subset: gosubset_prok
synonym: "growth or development within other organism during symbiotic interaction" EXACT []
synonym: "invasive growth" BROAD []
is_obsolete: true
replaced_by: GO:0044112
replaced_by: GO:0044113

[Term]
id: GO:0051832
name: avoidance of defenses of other organism during symbiotic interaction
namespace: biological_process
def: "Any process, either constitutive or induced, by which an organism evades, minimizes, or suppresses the effects of a second organism's defense(s), where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0052173 ! response to defenses of other organism during symbiotic interaction

[Term]
id: GO:0051833
name: suppression of defenses of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the defense(s) of a second organism, where the two organisms are in a symbiotic interaction. Suppression occurs by active mechanisms that normally result in the shutting down of pathways in the second organism." [GOC:cc]
subset: gosubset_prok
synonym: "negative regulation of defenses of other organism during symbiotic interaction" EXACT []
is_a: GO:0051832 ! avoidance of defenses of other organism during symbiotic interaction

[Term]
id: GO:0051834
name: evasion or tolerance of defenses of other organism during symbiotic interaction
namespace: biological_process
def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of a second organism's defense(s), where the two organisms are in a symbiotic interaction. Defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers)." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051832 ! avoidance of defenses of other organism during symbiotic interaction

[Term]
id: GO:0051835
name: positive regulation of synapse structural plasticity
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity." [GOC:ai]
synonym: "activation of synapse structural plasticity" NARROW []
synonym: "stimulation of synapse structural plasticity" NARROW []
synonym: "up regulation of synapse structural plasticity" EXACT []
synonym: "up-regulation of synapse structural plasticity" EXACT []
synonym: "upregulation of synapse structural plasticity" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051823 ! regulation of synapse structural plasticity

[Term]
id: GO:0051836
name: translocation of molecules into other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a molecule(s) produced by an organism to a location inside a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "transport of molecules into other organism during symbiotic interaction" EXACT []
is_a: GO:0006810 ! transport
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0051837
name: translocation of DNA into other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of DNA from an organism to a location inside a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
synonym: "transport of DNA into other organism during symbiotic interaction" EXACT []
is_a: GO:0051027 ! DNA transport
is_a: GO:0051836 ! translocation of molecules into other organism during symbiotic interaction

[Term]
id: GO:0051838
name: cytolysis by host of symbiont cells
namespace: biological_process
def: "The killing by an organism of a cell in its symbiont organism by means of the rupture of cell membranes and the loss of cytoplasm. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
is_a: GO:0051801 ! cytolysis of cells in other organism during symbiotic interaction
is_a: GO:0051873 ! killing by host of symbiont cells
is_a: GO:0052337 ! modification by host of symbiont cell membrane

[Term]
id: GO:0051839
name: regulation by host of cytolysis of symbiont cells
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
is_a: GO:0051802 ! regulation of cytolysis of cells in other organism during symbiotic interaction
relationship: regulates GO:0051838 ! cytolysis by host of symbiont cells

[Term]
id: GO:0051840
name: negative regulation by host of cytolysis of symbiont cells
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
synonym: "down regulation by host of cytolysis of symbiont cells" EXACT []
synonym: "down-regulation by host of cytolysis of symbiont cells" EXACT []
synonym: "downregulation by host of cytolysis of symbiont cells" EXACT []
synonym: "inhibition by host of cytolysis of symbiont cells" NARROW []
is_a: GO:0051803 ! negative regulation of cytolysis of cells in other organism during symbiotic interaction
is_a: GO:0051839 ! regulation by host of cytolysis of symbiont cells

[Term]
id: GO:0051841
name: positive regulation by host of cytolysis of symbiont cells
namespace: biological_process
def: "Any process by which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
synonym: "activation by host of cytolysis of symbiont cells" NARROW []
synonym: "stimulation by host of cytolysis of symbiont cells" NARROW []
synonym: "up regulation by host of cytolysis of symbiont cells" EXACT []
synonym: "up-regulation by host of cytolysis of symbiont cells" EXACT []
synonym: "upregulation by host of cytolysis of symbiont cells" EXACT []
is_a: GO:0051804 ! positive regulation of cytolysis of cells in other organism during symbiotic interaction
is_a: GO:0051839 ! regulation by host of cytolysis of symbiont cells

[Term]
id: GO:0051842
name: evasion or tolerance of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any process, either active or passive, by which an organism avoids the effects of the symbiont organism's immune response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mb]
comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature.
synonym: "immune evasion" BROAD []
is_obsolete: true

[Term]
id: GO:0051843
name: evasion or tolerance of symbiont defense response
namespace: biological_process
def: "OBSOLETE. Any process, either active or passive, by which an organism avoids or tolerates the effects of a symbiont organism's defense response. The symbiont defense response is mounted by the symbiont in response to the presence of the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mah]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "evasion of symbiont defence response" EXACT []
is_obsolete: true

[Term]
id: GO:0051844
name: translocation of peptides or proteins into symbiont
namespace: biological_process
def: "The directed movement of peptides or proteins produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "transport of peptides or proteins into symbiont" EXACT []
is_a: GO:0051808 ! translocation of peptides or proteins into other organism during symbiotic interaction
is_a: GO:0051862 ! translocation of molecules into symbiont

[Term]
id: GO:0051845
name: passive evasion of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any mechanism of immune avoidance that does not directly interfere with the symbiont immune system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "passive immune evasion" BROAD []
is_obsolete: true

[Term]
id: GO:0051846
name: active evasion of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any mechanism of immune avoidance that directly affects the symbiont immune system, e.g. blocking any stage in symbiont MHC class I and II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "active immune evasion" BROAD []
is_obsolete: true

[Term]
id: GO:0051847
name: active evasion of symbiont immune response via regulation of symbiont complement system
namespace: biological_process
def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating the symbiont complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, symbiont macrophages, which are eventually destroyed. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "active immune evasion via modulation of symbiont complement system" EXACT []
synonym: "active immune evasion via regulation of symbiont complement system" EXACT []
is_obsolete: true

[Term]
id: GO:0051848
name: active evasion of symbiont immune response via regulation of symbiont cytokine network
namespace: biological_process
def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating symbiont cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester symbiont cytokines and inhibit action. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "active immune evasion via modulation of symbiont cytokine network" EXACT []
synonym: "active immune evasion via regulation of symbiont cytokine network" EXACT []
is_obsolete: true

[Term]
id: GO:0051849
name: active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation
namespace: biological_process
def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating the symbiont's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
synonym: "active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation pathway" EXACT []
synonym: "active immune evasion via modulation of symbiont antigen processing and presentation" EXACT []
synonym: "active immune evasion via modulation of symbiont antigen processing/presentation" EXACT []
synonym: "active immune evasion via regulation of symbiont antigen processing or presentation" EXACT []
is_obsolete: true

[Term]
id: GO:0051850
name: acquisition of nutrients from symbiont
namespace: biological_process
def: "The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051702 ! interaction with symbiont
is_a: GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction

[Term]
id: GO:0051851
name: modification by host of symbiont morphology or physiology
namespace: biological_process
def: "The process by which an organism effects a change in the structure or processes of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051702 ! interaction with symbiont
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction

[Term]
id: GO:0051852
name: disruption by host of symbiont cells
namespace: biological_process
def: "Any process by which an organism has a negative effect on the functioning of the symbiont's cells. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051818 ! disruption of cells of other organism during symbiotic interaction
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology

[Term]
id: GO:0051853
name: induction in symbiont of tumor, nodule, or growth
namespace: biological_process
def: "OBSOLETE. The process by which an associated organism causes the formation of an abnormal mass of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
is_obsolete: true

[Term]
id: GO:0051854
name: induction in symbiont of tumor, nodule, or growth containing transformed cells
namespace: biological_process
def: "OBSOLETE. The process by which an organism causes the formation in its symbiont organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
is_obsolete: true

[Term]
id: GO:0051855
name: recognition of symbiont
namespace: biological_process
def: "The set of specific processes that allow an organism to detect the presence of its symbiont via physical or chemical signals. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0009602 ! detection of symbiont
is_a: GO:0051702 ! interaction with symbiont
is_a: GO:0051824 ! recognition of other organism during symbiotic interaction

[Term]
id: GO:0051856
name: adhesion to symbiont
namespace: biological_process
def: "The attachment of an organism to its symbiont via adhesion molecules, general stickiness etc., either directly or indirectly. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051702 ! interaction with symbiont
is_a: GO:0051825 ! adhesion to other organism during symbiotic interaction

[Term]
id: GO:0051857
name: growth or development of organism on or near symbiont surface
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of organism on or near symbiont surface ; GO:0044151' and 'development of organism on or near symbiont surface ; GO:0044150'.
subset: gosubset_prok
synonym: "growth or development of organism during interaction with symbiont" EXACT []
is_obsolete: true
replaced_by: GO:0044150
replaced_by: GO:0044151

[Term]
id: GO:0051858
name: avoidance of symbiont defenses
namespace: biological_process
def: "Any process, either constitutive or induced, by which an organism evades, minimizes, or suppresses the effects of its symbiont organism's defense(s). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051702 ! interaction with symbiont
is_a: GO:0051832 ! avoidance of defenses of other organism during symbiotic interaction
is_a: GO:0052201 ! response to symbiont defenses

[Term]
id: GO:0051859
name: suppression of symbiont defenses
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont defense(s) by active mechanisms that normally result in the shutting down of a symbiont pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051833 ! suppression of defenses of other organism during symbiotic interaction
is_a: GO:0051858 ! avoidance of symbiont defenses

[Term]
id: GO:0051860
name: evasion or tolerance of symbiont defenses
namespace: biological_process
def: "The process, either active or passive, by which an organism evades or tolerates the effects of the defense(s) or defense molecules of a symbiont organism. Symbiont defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
is_a: GO:0051834 ! evasion or tolerance of defenses of other organism during symbiotic interaction
is_a: GO:0051858 ! avoidance of symbiont defenses

[Term]
id: GO:0051861
name: glycolipid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate." [http://www.chem.qmul.ac.uk/iupac/misc/glylp.html#2.1]
is_a: GO:0008289 ! lipid binding

[Term]
id: GO:0051862
name: translocation of molecules into symbiont
namespace: biological_process
def: "The directed movement of molecule(s) produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "transport of molecules into symbiont" EXACT []
is_a: GO:0051702 ! interaction with symbiont
is_a: GO:0051836 ! translocation of molecules into other organism during symbiotic interaction

[Term]
id: GO:0051863
name: translocation of DNA into symbiont
namespace: biological_process
def: "OBSOLETE. The directed movement of DNA from an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
comment: This term was made obsolete because it does not represent a real process that exists in nature.
is_obsolete: true

[Term]
id: GO:0051864
name: histone demethylase activity (H3-K36 specific)
namespace: molecular_function
def: "Catalysis of the reaction: methyl-lysine + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. The methyl-lysine residue is at position 36 of histone 3." [PMID:16362057]
synonym: "[histone-H3]-lysine-36 demethylase activity" EXACT []
synonym: "H3-K36-specific demethylase activity" EXACT [EC:1.14.11.27]
synonym: "histone H3-lysine-36 demethylase activity" EXACT [EC:1.14.11.27]
synonym: "histone-lysine (H3-K36) demethylase activity" EXACT [EC:1.14.11.27]
synonym: "histone-lysine demethylase activity (H3-K36 specific)" EXACT []
synonym: "histone-lysine(H3-K36) demethylase activity" EXACT []
synonym: "JHDM1A activity" NARROW [EC:1.14.11.27]
synonym: "JmjC domain-containing histone demethylase 1A activity" NARROW [EC:1.14.11.27]
synonym: "protein-6-N,6-N-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.27]
synonym: "protein-N6,N6-dimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase activity" EXACT [EC:1.14.11.27]
xref: EC:1.14.11.27
xref: MetaCyc:RXN-8660
xref: MetaCyc:RXN-8661
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
is_a: GO:0032452 ! histone demethylase activity

[Term]
id: GO:0051865
name: protein autoubiquitination
namespace: biological_process
def: "The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai]
synonym: "protein auto-ubiquitination" EXACT []
synonym: "protein auto-ubiquitinylation" EXACT []
synonym: "protein autoubiquitinylation" EXACT []
synonym: "protein self-ubiquitination" EXACT []
synonym: "protein self-ubiquitinylation" EXACT []
is_a: GO:0016567 ! protein ubiquitination

[Term]
id: GO:0051866
name: general adaptation syndrome
namespace: biological_process
alt_id: GO:0051868
def: "General adaptation syndrome is the set of changes in various organ systems of the body, especially the pituitary-endocrine system, in response to a wide range of strong external stimuli, both physiological and psychological. It is described as having three stages: alarm reaction, where the body detects the external stimulus; adaptation, where the body engages defensive countermeasures against the stressor; and exhaustion, where the body begins to run out of defenses." [http://www.onelook.com, Wikipedia:General_adaptation_syndrome]
synonym: "general adaptation syndrome, physiological process" EXACT []
synonym: "general adaptation syndrome, physiological response" EXACT []
synonym: "physiological process during general adaptation syndrome" EXACT []
synonym: "physiological response during general adaptation syndrome" EXACT []
is_a: GO:0033555 ! multicellular organismal response to stress

[Term]
id: GO:0051867
name: general adaptation syndrome, behavioral process
namespace: biological_process
def: "The set of behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus." [GOC:ai]
synonym: "behavioral process during general adaptation syndrome" EXACT []
synonym: "behavioral response during general adaptation syndrome" EXACT []
synonym: "behavioural process during general adaptation syndrome" EXACT []
synonym: "behavioural response during general adaptation syndrome" EXACT []
synonym: "general adaptation syndrome, behavioral response" EXACT []
synonym: "general adaptation syndrome, behavioural process" EXACT []
synonym: "general adaptation syndrome, behavioural response" EXACT []
is_a: GO:0007610 ! behavior
relationship: part_of GO:0051866 ! general adaptation syndrome

[Term]
id: GO:0051870
name: methotrexate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA." [GOC:nln]
subset: gosubset_prok
is_a: GO:0031406 ! carboxylic acid binding

[Term]
id: GO:0051871
name: dihydrofolic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "DHF binding" RELATED []
synonym: "dihydrofolate binding" RELATED []
is_a: GO:0005488 ! binding

[Term]
id: GO:0051872
name: sphingosine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ai]
synonym: "(4E)-sphing-4-enine catabolic process" EXACT []
synonym: "(4E)-sphing-4-enine catabolism" EXACT []
synonym: "sphing-4-enine catabolic process" EXACT []
synonym: "sphing-4-enine catabolism" EXACT []
is_a: GO:0006670 ! sphingosine metabolic process
is_a: GO:0009310 ! amine catabolic process
is_a: GO:0046164 ! alcohol catabolic process
is_a: GO:0046521 ! sphingoid catabolic process

[Term]
id: GO:0051873
name: killing by host of symbiont cells
namespace: biological_process
def: "Any process mediated by an organism that results in the death of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
is_a: GO:0051852 ! disruption by host of symbiont cells
is_a: GO:0051883 ! killing of cells in other organism during symbiotic interaction

[Term]
id: GO:0051874
name: sphinganine-1-phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai]
synonym: "dihydrosphingosine-1-phosphate catabolic process" EXACT []
synonym: "dihydrosphingosine-1-phosphate catabolism" EXACT []
is_a: GO:0006668 ! sphinganine-1-phosphate metabolic process
is_a: GO:0009395 ! phospholipid catabolic process
is_a: GO:0030149 ! sphingolipid catabolic process

[Term]
id: GO:0051875
name: pigment granule localization
namespace: biological_process
def: "Any process by which a pigment granule is transported to, and/or maintained in, a specific location within the cell." [GOC:ai]
is_a: GO:0051648 ! vesicle localization
relationship: part_of GO:0033059 ! cellular pigmentation

[Term]
id: GO:0051876
name: pigment granule dispersal
namespace: biological_process
def: "The directed movement of pigment granules within a cell towards the cell periphery." [GOC:mh]
is_a: GO:0051905 ! establishment of pigment granule localization

[Term]
id: GO:0051877
name: pigment granule aggregation in cell center
namespace: biological_process
def: "The directed movement of dispersed pigment granules towards the center of the cell." [GOC:mh]
is_a: GO:0051905 ! establishment of pigment granule localization

[Term]
id: GO:0051878
name: lateral element assembly
namespace: biological_process
def: "The cell cycle process whereby lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements." [PMID:11463847]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0007130 ! synaptonemal complex assembly

[Term]
id: GO:0051879
name: Hsp90 protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai]
synonym: "Hsp90 binding" EXACT []
synonym: "Hsp90 class protein binding" EXACT []
is_a: GO:0031072 ! heat shock protein binding

[Term]
id: GO:0051880
name: G-quadruplex DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome." [PMID:16142245, PMID:9512530]
synonym: "G quadruplex DNA binding" EXACT [GOC:mah]
synonym: "G quartet binding" BROAD [GOC:mah]
synonym: "G quartet DNA binding" EXACT [GOC:mah]
synonym: "G-DNA binding" EXACT []
synonym: "G-quartet binding" BROAD [GOC:mah]
synonym: "G-quartet DNA binding" EXACT [GOC:mah]
synonym: "quadruplex DNA binding" EXACT []
synonym: "tetraplex DNA binding" EXACT []
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0051881
name: regulation of mitochondrial membrane potential
namespace: biological_process
def: "Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0051882
name: mitochondrial depolarization
namespace: biological_process
def: "The process in which the membrane potential of the mitochondria changes in the depolarizing direction from the resting potential, from negative to positive." [Wikipedia:Depolarization, Wikipedia:Mitochondrion]
synonym: "mitochondria depolarization" EXACT []
synonym: "mitochondrial depolarisation" EXACT []
synonym: "mitochondrial membrane depolarization" EXACT []
synonym: "mitochondrion depolarization" EXACT []
is_a: GO:0051881 ! regulation of mitochondrial membrane potential
is_a: GO:0051899 ! membrane depolarization

[Term]
id: GO:0051883
name: killing of cells in other organism during symbiotic interaction
namespace: biological_process
def: "Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add]
subset: gosubset_prok
is_a: GO:0031640 ! killing of cells of another organism
is_a: GO:0051818 ! disruption of cells of other organism during symbiotic interaction

[Term]
id: GO:0051884
name: regulation of anagen
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of anagen, the growth phase of the hair cycle." [GOC:ai]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0048819 ! regulation of hair follicle maturation
relationship: regulates GO:0042640 ! anagen

[Term]
id: GO:0051885
name: positive regulation of anagen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of anagen, the growth phase of the hair cycle." [GOC:ai]
synonym: "activation of anagen" NARROW []
synonym: "stimulation of anagen" NARROW []
synonym: "up regulation of anagen" EXACT []
synonym: "up-regulation of anagen" EXACT []
synonym: "upregulation of anagen" EXACT []
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0048818 ! positive regulation of hair follicle maturation
is_a: GO:0051884 ! regulation of anagen
relationship: positively_regulates GO:0042640 ! anagen

[Term]
id: GO:0051886
name: negative regulation of anagen
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of anagen, the growth phase of the hair cycle." [GOC:ai]
synonym: "down regulation of anagen" EXACT []
synonym: "down-regulation of anagen" EXACT []
synonym: "downregulation of anagen" EXACT []
synonym: "inhibition of anagen" NARROW []
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0048817 ! negative regulation of hair follicle maturation
is_a: GO:0051884 ! regulation of anagen
relationship: negatively_regulates GO:0042640 ! anagen

[Term]
id: GO:0051887
name: regulation of exogen
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of exogen, the shedding phase of the hair cycle." [GOC:ai]
is_a: GO:0048819 ! regulation of hair follicle maturation
relationship: regulates GO:0042638 ! exogen

[Term]
id: GO:0051888
name: positive regulation of exogen
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of exogen, the shedding phase of the hair cycle." [GOC:ai]
synonym: "activation of exogen" NARROW []
synonym: "stimulation of exogen" NARROW []
synonym: "up regulation of exogen" EXACT []
synonym: "up-regulation of exogen" EXACT []
synonym: "upregulation of exogen" EXACT []
is_a: GO:0048818 ! positive regulation of hair follicle maturation
is_a: GO:0051887 ! regulation of exogen
relationship: positively_regulates GO:0042638 ! exogen

[Term]
id: GO:0051889
name: negative regulation of exogen
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of exogen, the shedding phase of the hair cycle." [GOC:ai]
synonym: "down regulation of exogen" EXACT []
synonym: "down-regulation of exogen" EXACT []
synonym: "downregulation of exogen" EXACT []
synonym: "inhibition of exogen" NARROW []
is_a: GO:0048817 ! negative regulation of hair follicle maturation
is_a: GO:0051887 ! regulation of exogen
relationship: negatively_regulates GO:0042638 ! exogen

[Term]
id: GO:0051890
name: regulation of cardioblast differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0051891
name: positive regulation of cardioblast differentiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai]
synonym: "activation of cardioblast differentiation" NARROW []
synonym: "stimulation of cardioblast differentiation" NARROW []
synonym: "up regulation of cardioblast differentiation" EXACT []
synonym: "up-regulation of cardioblast differentiation" EXACT []
synonym: "upregulation of cardioblast differentiation" EXACT []
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0051890 ! regulation of cardioblast differentiation
relationship: positively_regulates GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0051892
name: negative regulation of cardioblast differentiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardioblast differentiation, the process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai]
synonym: "down regulation of cardioblast differentiation" EXACT []
synonym: "down-regulation of cardioblast differentiation" EXACT []
synonym: "downregulation of cardioblast differentiation" EXACT []
synonym: "inhibition of cardioblast differentiation" NARROW []
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0051890 ! regulation of cardioblast differentiation
relationship: negatively_regulates GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0051893
name: regulation of focal adhesion assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions." [GOC:ai]
is_a: GO:0001952 ! regulation of cell-matrix adhesion
is_a: GO:0090109 ! regulation of cell-substrate junction assembly
relationship: regulates GO:0048041 ! focal adhesion assembly

[Term]
id: GO:0051894
name: positive regulation of focal adhesion assembly
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions." [GOC:ai]
synonym: "activation of focal adhesion formation" NARROW []
synonym: "stimulation of focal adhesion formation" NARROW []
synonym: "up regulation of focal adhesion formation" EXACT []
synonym: "up-regulation of focal adhesion formation" EXACT []
synonym: "upregulation of focal adhesion formation" EXACT []
is_a: GO:0001954 ! positive regulation of cell-matrix adhesion
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051893 ! regulation of focal adhesion assembly
relationship: positively_regulates GO:0048041 ! focal adhesion assembly

[Term]
id: GO:0051895
name: negative regulation of focal adhesion assembly
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions." [GOC:ai]
synonym: "down regulation of focal adhesion formation" EXACT []
synonym: "down-regulation of focal adhesion formation" EXACT []
synonym: "downregulation of focal adhesion formation" EXACT []
synonym: "inhibition of focal adhesion formation" NARROW []
is_a: GO:0001953 ! negative regulation of cell-matrix adhesion
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051893 ! regulation of focal adhesion assembly
relationship: negatively_regulates GO:0048041 ! focal adhesion assembly

[Term]
id: GO:0051896
name: regulation of protein kinase B signaling cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the protein kinase B signaling cascade, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai]
synonym: "regulation of AKT signaling cascade" EXACT []
synonym: "regulation of AKT signalling cascade" EXACT []
synonym: "regulation of PKB signaling cascade" EXACT []
synonym: "regulation of PKB signalling cascade" EXACT []
synonym: "regulation of protein kinase B signalling cascade" EXACT []
is_a: GO:0010627 ! regulation of protein kinase cascade
relationship: regulates GO:0043491 ! protein kinase B signaling cascade

[Term]
id: GO:0051897
name: positive regulation of protein kinase B signaling cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the protein kinase B signaling cascade, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai]
synonym: "activation of protein kinase B signaling cascade" NARROW []
synonym: "positive regulation of AKT signaling cascade" EXACT []
synonym: "positive regulation of AKT signalling cascade" EXACT []
synonym: "positive regulation of PKB signaling cascade" EXACT []
synonym: "positive regulation of PKB signalling cascade" EXACT []
synonym: "positive regulation of protein kinase B signalling cascade" EXACT []
synonym: "stimulation of protein kinase B signaling cascade" NARROW []
synonym: "up regulation of protein kinase B signaling cascade" EXACT []
synonym: "up-regulation of protein kinase B signaling cascade" EXACT []
synonym: "upregulation of protein kinase B signaling cascade" EXACT []
is_a: GO:0010740 ! positive regulation of protein kinase cascade
is_a: GO:0051896 ! regulation of protein kinase B signaling cascade
relationship: positively_regulates GO:0043491 ! protein kinase B signaling cascade

[Term]
id: GO:0051898
name: negative regulation of protein kinase B signaling cascade
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the protein kinase B signaling cascade, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai]
synonym: "down regulation of protein kinase B signaling cascade" EXACT []
synonym: "down-regulation of protein kinase B signaling cascade" EXACT []
synonym: "downregulation of protein kinase B signaling cascade" EXACT []
synonym: "inhibition of protein kinase B signaling cascade" NARROW []
synonym: "negative regulation of AKT signaling cascade" EXACT []
synonym: "negative regulation of AKT signalling cascade" EXACT []
synonym: "negative regulation of PKB signaling cascade" EXACT []
synonym: "negative regulation of PKB signalling cascade" EXACT []
synonym: "negative regulation of protein kinase B signalling cascade" EXACT []
is_a: GO:0010741 ! negative regulation of protein kinase cascade
is_a: GO:0051896 ! regulation of protein kinase B signaling cascade
relationship: negatively_regulates GO:0043491 ! protein kinase B signaling cascade

[Term]
id: GO:0051899
name: membrane depolarization
namespace: biological_process
def: "The process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [Wikipedia:Depolarization]
xref: Reactome:112308 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels"
xref: Reactome:448939 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels"
xref: Reactome:470058 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels"
xref: Reactome:487754 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels"
xref: Reactome:507714 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels"
xref: Reactome:526483 "Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels"
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0051900
name: regulation of mitochondrial depolarization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai]
is_a: GO:0003254 ! regulation of membrane depolarization
relationship: regulates GO:0051882 ! mitochondrial depolarization

[Term]
id: GO:0051901
name: positive regulation of mitochondrial depolarization
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai]
synonym: "activation of mitochondrial depolarization" NARROW []
synonym: "stimulation of mitochondrial depolarization" NARROW []
synonym: "up regulation of mitochondrial depolarization" EXACT []
synonym: "up-regulation of mitochondrial depolarization" EXACT []
synonym: "upregulation of mitochondrial depolarization" EXACT []
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051900 ! regulation of mitochondrial depolarization
relationship: positively_regulates GO:0051882 ! mitochondrial depolarization

[Term]
id: GO:0051902
name: negative regulation of mitochondrial depolarization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai]
synonym: "down regulation of mitochondrial depolarization" EXACT []
synonym: "down-regulation of mitochondrial depolarization" EXACT []
synonym: "downregulation of mitochondrial depolarization" EXACT []
synonym: "inhibition of mitochondrial depolarization" NARROW []
is_a: GO:0032845 ! negative regulation of homeostatic process
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051900 ! regulation of mitochondrial depolarization
relationship: negatively_regulates GO:0051882 ! mitochondrial depolarization

[Term]
id: GO:0051903
name: S-(hydroxymethyl)glutathione dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+." [EC:1.1.1.284]
synonym: "ADH3 activity" NARROW [EC:1.1.1.284]
synonym: "chi-ADH activity" NARROW [EC:1.1.1.284]
synonym: "class III alcohol dehydrogenase activity" RELATED [EC:1.1.1.284]
synonym: "FDH activity" RELATED [EC:1.1.1.284]
synonym: "formic dehydrogenase activity" RELATED [EC:1.1.1.284]
synonym: "GD-FALDH activity" EXACT [EC:1.1.1.284]
synonym: "glutathione-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284]
synonym: "GS-FDH activity" EXACT [EC:1.1.1.284]
synonym: "NAD- and glutathione-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284]
synonym: "NAD-dependent formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284]
synonym: "NAD-linked formaldehyde dehydrogenase activity" EXACT [EC:1.1.1.284]
synonym: "S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.284]
xref: EC:1.1.1.284
xref: MetaCyc:RXN-2962
xref: UM-BBD_enzymeID:e0709
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0051904
name: pigment granule transport
namespace: biological_process
def: "The directed movement of pigment granules into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
synonym: "pigment granule translocation" EXACT []
is_a: GO:0006810 ! transport
is_a: GO:0051905 ! establishment of pigment granule localization

[Term]
id: GO:0051905
name: establishment of pigment granule localization
namespace: biological_process
def: "The directed movement of a pigment granule to a specific location." [GOC:ai]
is_a: GO:0051650 ! establishment of vesicle localization
relationship: part_of GO:0051875 ! pigment granule localization

[Term]
id: GO:0051906
name: maintenance of pigment granule location
namespace: biological_process
def: "Any process by which a pigment granule is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]
synonym: "maintenance of pigment granule localization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051655 ! maintenance of vesicle location
relationship: part_of GO:0051875 ! pigment granule localization

[Term]
id: GO:0051907
name: S-(hydroxymethyl)glutathione synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione = glutathione + formaldehyde." [EC:4.4.1.22]
synonym: "Gfa" RELATED [EC:4.4.1.22]
synonym: "glutathione-dependent formaldehyde-activating enzyme activity" EXACT []
synonym: "S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)" EXACT [EC:4.4.1.22]
synonym: "S-(hydroxymethyl)glutathione formaldehyde-lyase activity" EXACT [EC:4.4.1.22]
xref: EC:4.4.1.22
xref: MetaCyc:RXN-2961
xref: UM-BBD_enzymeID:e0710
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0051908
name: double-stranded DNA specific 5'-3' exodeoxyribonuclease activity
namespace: molecular_function
def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule." [GOC:ai]
is_a: GO:0008309 ! double-stranded DNA specific exodeoxyribonuclease activity
is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity

[Term]
id: GO:0051909
name: acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O." [MetaCyc:ACETYLENECARBOXYLATE-HYDRATASE-RXN]
synonym: "3-hydroxypropenoate dehydratase activity" EXACT []
synonym: "acetylenecarboxylate hydratase activity" BROAD []
synonym: "acetylenemonocarboxylate hydratase activity" BROAD []
synonym: "alkynoate hydratase activity" BROAD []
xref: EC:4.2.1.-
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0051910
name: heparitin sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparitin = adenosine 3',5'-bisphosphate + N-sulfoheparitin." [MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN]
synonym: "heparitin N-sulfotransferase activity" EXACT []
synonym: "heparitin N-sulphotransferase activity" EXACT []
xref: MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0051911
name: Methanosarcina-phenazine hydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine." [EC:1.12.98.3]
synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" RELATED []
synonym: "hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase activity" EXACT [EC:1.12.98.3]
synonym: "methanophenazine hydrogenase activity" EXACT []
synonym: "methylviologen-reducing hydrogenase activity" EXACT []
xref: EC:1.12.98.3
xref: MetaCyc:RXN-7733
is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors

[Term]
id: GO:0051912
name: CoB--CoM heterodisulfide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine." [EC:1.8.98.1]
synonym: "CoB-CoM heterodisulfide reductase activity" EXACT []
synonym: "coenzyme B--coenzyme M heterodisulfide reductase activity" EXACT []
synonym: "coenzyme B:coenzyme M:methanophenazine oxidoreductase activity" EXACT [EC:1.8.98.1]
synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" RELATED []
synonym: "heterodisulfide reductase activity" BROAD []
synonym: "soluble heterodisulfide reductase activity" RELATED [EC:1.8.98.1]
xref: EC:1.8.98.1
xref: MetaCyc:1.8.98.1-RXN
is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors

[Term]
id: GO:0051913
name: regulation of synaptic plasticity by chemical substance
namespace: biological_process
def: "The process by which a chemical substance modulates synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai]
synonym: "regulation of synaptic plasticity by drug" NARROW []
is_a: GO:0042221 ! response to chemical stimulus
is_a: GO:0048167 ! regulation of synaptic plasticity

[Term]
id: GO:0051914
name: positive regulation of synaptic plasticity by chemical substance
namespace: biological_process
def: "The process by which a chemical substance increases synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai]
synonym: "activation of synaptic plasticity by chemical substance" NARROW []
synonym: "positive regulation of synaptic plasticity by drug" NARROW []
synonym: "stimulation of synaptic plasticity by chemical substance" NARROW []
synonym: "up regulation of synaptic plasticity by chemical substance" EXACT []
synonym: "up-regulation of synaptic plasticity by chemical substance" EXACT []
synonym: "upregulation of synaptic plasticity by chemical substance" EXACT []
is_a: GO:0031915 ! positive regulation of synaptic plasticity
is_a: GO:0051913 ! regulation of synaptic plasticity by chemical substance

[Term]
id: GO:0051915
name: induction of synaptic plasticity by chemical substance
namespace: biological_process
def: "The process by which a chemical substance activates synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai]
synonym: "activation of synaptic plasticity by chemical substance" EXACT []
synonym: "activation of synaptic plasticity by drug" NARROW []
synonym: "induction of synaptic plasticity by drug" NARROW []
is_a: GO:0051914 ! positive regulation of synaptic plasticity by chemical substance

[Term]
id: GO:0051916
name: granulocyte colony-stimulating factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with granulocyte colony-stimulating factor, G-CSF." [GOC:ai]
synonym: "G-CSF binding" EXACT []
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0051917
name: regulation of fibrinolysis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0042730 ! fibrinolysis

[Term]
id: GO:0051918
name: negative regulation of fibrinolysis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai]
synonym: "down regulation of fibrinolysis" EXACT []
synonym: "down-regulation of fibrinolysis" EXACT []
synonym: "downregulation of fibrinolysis" EXACT []
synonym: "inhibition of fibrinolysis" NARROW []
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0051917 ! regulation of fibrinolysis
relationship: negatively_regulates GO:0042730 ! fibrinolysis

[Term]
id: GO:0051919
name: positive regulation of fibrinolysis
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai]
synonym: "activation of fibrinolysis" NARROW []
synonym: "stimulation of fibrinolysis" NARROW []
synonym: "up regulation of fibrinolysis" EXACT []
synonym: "up-regulation of fibrinolysis" EXACT []
synonym: "upregulation of fibrinolysis" EXACT []
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0051917 ! regulation of fibrinolysis
relationship: positively_regulates GO:0042730 ! fibrinolysis

[Term]
id: GO:0051920
name: peroxiredoxin activity
namespace: molecular_function
def: "Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH." [EC:1.11.1.15]
subset: gosubset_prok
synonym: "AhpC activity" NARROW []
synonym: "alkyl hydroperoxide reductase C22 activity" NARROW []
synonym: "PRDX activity" EXACT []
synonym: "Prx activity" EXACT []
synonym: "thiol-containing-reductant:hydroperoxide oxidoreductase activity" EXACT [EC:1.11.1.15]
xref: EC:1.11.1.15
xref: MetaCyc:1.11.1.15-RXN
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0051921
name: adenosylcobyric acid synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def: "Catalysis of the reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate." [EC:6.3.5.10]
synonym: "5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase activity" EXACT []
synonym: "adenosylcobyric acid synthase (glutamine-hydrolysing) activity" EXACT []
synonym: "adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.10]
synonym: "Ado-cobyric acid synthase [glutamine hydrolyzing] activity" EXACT []
synonym: "CobQ activity" BROAD []
synonym: "cobyric acid synthase activity" RELATED []
xref: EC:6.3.5.10
xref: MetaCyc:R345-RXN
is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor

[Term]
id: GO:0051922
name: cholesterol sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate." [PMID:12730293]
xref: EC:2.8.2.-
is_a: GO:0004027 ! alcohol sulfotransferase activity

[Term]
id: GO:0051923
name: sulfation
namespace: biological_process
def: "The addition of a sulfate group to a molecule." [http://www.onelook.com]
subset: gosubset_prok
synonym: "sulfur addition" EXACT []
synonym: "sulphation" EXACT []
synonym: "sulphur addition" EXACT []
is_a: GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0051924
name: regulation of calcium ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
synonym: "regulation of calcium transport" EXACT []
is_a: GO:0010959 ! regulation of metal ion transport
relationship: regulates GO:0006816 ! calcium ion transport

[Term]
id: GO:0051925
name: regulation of calcium ion transport via voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel." [GOC:ai]
synonym: "regulation of calcium transport via voltage-gated calcium channel" EXACT []
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:0051924 ! regulation of calcium ion transport

[Term]
id: GO:0051926
name: negative regulation of calcium ion transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of calcium ion transport" EXACT []
synonym: "down-regulation of calcium ion transport" EXACT []
synonym: "downregulation of calcium ion transport" EXACT []
synonym: "inhibition of calcium ion transport" NARROW []
synonym: "negative regulation of calcium transport" EXACT []
is_a: GO:0043271 ! negative regulation of ion transport
is_a: GO:0051924 ! regulation of calcium ion transport
relationship: negatively_regulates GO:0006816 ! calcium ion transport

[Term]
id: GO:0051927
name: negative regulation of calcium ion transport via voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel." [GOC:ai]
synonym: "down regulation of calcium ion transport via voltage gated calcium channel" EXACT []
synonym: "down-regulation of calcium ion transport via voltage gated calcium channel" EXACT []
synonym: "downregulation of calcium ion transport via voltage gated calcium channel" EXACT []
synonym: "inhibition of calcium ion transport via voltage gated calcium channel" NARROW []
synonym: "negative regulation of calcium transport via voltage gated calcium channel" RELATED []
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:0051925 ! regulation of calcium ion transport via voltage-gated calcium channel activity
is_a: GO:0051926 ! negative regulation of calcium ion transport

[Term]
id: GO:0051928
name: positive regulation of calcium ion transport
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
synonym: "activation of calcium ion transport" NARROW []
synonym: "positive regulation of calcium transport" EXACT []
synonym: "stimulation of calcium ion transport" NARROW []
synonym: "up regulation of calcium ion transport" EXACT []
synonym: "up-regulation of calcium ion transport" EXACT []
synonym: "upregulation of calcium ion transport" EXACT []
is_a: GO:0043270 ! positive regulation of ion transport
is_a: GO:0051924 ! regulation of calcium ion transport
relationship: positively_regulates GO:0006816 ! calcium ion transport

[Term]
id: GO:0051929
name: positive regulation of calcium ion transport via voltage-gated calcium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via the activity of voltage-gated calcium channels." [GOC:ai]
synonym: "activation of calcium ion transport via voltage gated calcium channel" NARROW []
synonym: "positive regulation of calcium transport via voltage gated calcium channel" EXACT []
synonym: "stimulation of calcium ion transport via voltage gated calcium channel" NARROW []
synonym: "up regulation of calcium ion transport via voltage gated calcium channel" EXACT []
synonym: "up-regulation of calcium ion transport via voltage gated calcium channel" EXACT []
synonym: "upregulation of calcium ion transport via voltage gated calcium channel" EXACT []
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:0051925 ! regulation of calcium ion transport via voltage-gated calcium channel activity
is_a: GO:0051928 ! positive regulation of calcium ion transport

[Term]
id: GO:0051930
name: regulation of sensory perception of pain
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai]
is_a: GO:0051931 ! regulation of sensory perception
relationship: regulates GO:0019233 ! sensory perception of pain

[Term]
id: GO:0051931
name: regulation of sensory perception
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai]
is_a: GO:0031644 ! regulation of neurological system process
relationship: regulates GO:0007600 ! sensory perception

[Term]
id: GO:0051932
name: synaptic transmission, GABAergic
namespace: biological_process
def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [ISBN:0126603030]
synonym: "synaptic transmission, GABA mediated" EXACT []
synonym: "synaptic transmission, gamma-aminobutyric acid mediated" EXACT []
synonym: "synaptic transmission, gamma-aminobutyric acid-ergic" EXACT []
is_a: GO:0007270 ! nerve-nerve synaptic transmission

[Term]
id: GO:0051933
name: amino acid uptake during transmission of nerve impulse
namespace: biological_process
def: "The uptake of amino acid neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387]
synonym: "amino acid neurotransmitter import into glial cell" NARROW []
synonym: "amino acid neurotransmitter import into neuron" NARROW []
synonym: "amino acid neurotransmitter recycling" BROAD []
synonym: "amino acid neurotransmitter reuptake" EXACT []
is_a: GO:0001504 ! neurotransmitter uptake
is_a: GO:0043090 ! amino acid import

[Term]
id: GO:0051934
name: catecholamine uptake during transmission of nerve impulse
namespace: biological_process
def: "The uptake of catecholamine neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387]
synonym: "catecholamine neurotransmitter import into glial cell" NARROW []
synonym: "catecholamine neurotransmitter import into neuron" NARROW []
synonym: "catecholamine neurotransmitter recycling" BROAD []
synonym: "catecholamine neurotransmitter reuptake" EXACT []
synonym: "catecholamine reuptake during transmission of nerve impulse" EXACT []
is_a: GO:0001504 ! neurotransmitter uptake
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0051935
name: glutamate uptake during transmission of nerve impulse
namespace: biological_process
def: "The uptake of L-glutamate by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387]
synonym: "glutamate import into glial cell" NARROW []
synonym: "glutamate import into neuron" NARROW []
synonym: "glutamate recycling" BROAD []
synonym: "glutamate reuptake" EXACT []
synonym: "L-glutamate reuptake" EXACT []
synonym: "L-glutamate uptake during transmission of nerve impulse" EXACT []
is_a: GO:0051933 ! amino acid uptake during transmission of nerve impulse
is_a: GO:0051938 ! L-glutamate import

[Term]
id: GO:0051936
name: gamma-aminobutyric acid uptake during transmission of nerve impulse
namespace: biological_process
def: "The uptake of gamma-aminobutyric acid (GABA, 4-aminobutyrate) by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387]
synonym: "GABA import into glial cell" NARROW []
synonym: "GABA import into neuron" NARROW []
synonym: "GABA recycling" BROAD []
synonym: "GABA reuptake" EXACT []
synonym: "gamma-aminobutyric acid import into glial cell" NARROW []
synonym: "gamma-aminobutyric acid import into neuron" NARROW []
synonym: "gamma-aminobutyric acid recycling" BROAD []
synonym: "gamma-aminobutyric acid reuptake" EXACT []
is_a: GO:0051933 ! amino acid uptake during transmission of nerve impulse
is_a: GO:0051939 ! gamma-aminobutyric acid import

[Term]
id: GO:0051937
name: catecholamine transport
namespace: biological_process
def: "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0015844 ! monoamine transport
is_a: GO:0015850 ! organic alcohol transport

[Term]
id: GO:0051938
name: L-glutamate import
namespace: biological_process
def: "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "L-glutamate uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015813 ! L-glutamate transport
is_a: GO:0043092 ! L-amino acid import

[Term]
id: GO:0051939
name: gamma-aminobutyric acid import
namespace: biological_process
def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle." [GOC:ai]
subset: gosubset_prok
synonym: "4-aminobutyrate import" EXACT []
synonym: "GABA import" EXACT []
synonym: "gamma-aminobutyrate import" EXACT []
synonym: "gamma-aminobutyric acid uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0015800 ! acidic amino acid transport
is_a: GO:0015812 ! gamma-aminobutyric acid transport
is_a: GO:0043092 ! L-amino acid import

[Term]
id: GO:0051940
name: regulation of catecholamine uptake during transmission of nerve impulse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai]
synonym: "regulation of catecholamine neurotransmitter reuptake" EXACT []
synonym: "regulation of catecholamine neurotransmitter uptake" EXACT []
is_a: GO:0051580 ! regulation of neurotransmitter uptake
is_a: GO:0051952 ! regulation of amine transport
relationship: regulates GO:0051934 ! catecholamine uptake during transmission of nerve impulse

[Term]
id: GO:0051941
name: regulation of amino acid uptake during transmission of nerve impulse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai]
synonym: "regulation of amino acid neurotransmitter reuptake" EXACT []
synonym: "regulation of amino acid neurotransmitter uptake" EXACT []
is_a: GO:0010958 ! regulation of amino acid import
is_a: GO:0051580 ! regulation of neurotransmitter uptake
relationship: regulates GO:0051933 ! amino acid uptake during transmission of nerve impulse

[Term]
id: GO:0051942
name: negative regulation of amino acid uptake during transmission of nerve impulse
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai]
synonym: "down regulation of amino acid uptake during transmission of nerve impulse" EXACT []
synonym: "down-regulation of amino acid uptake during transmission of nerve impulse" EXACT []
synonym: "downregulation of amino acid uptake during transmission of nerve impulse" EXACT []
synonym: "inhibition of amino acid uptake during transmission of nerve impulse" NARROW []
synonym: "negative regulation of amino acid neurotransmitter reuptake" EXACT []
synonym: "negative regulation of amino acid neurotransmitter uptake" EXACT []
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake
is_a: GO:0051941 ! regulation of amino acid uptake during transmission of nerve impulse
is_a: GO:0051956 ! negative regulation of amino acid transport
relationship: negatively_regulates GO:0051933 ! amino acid uptake during transmission of nerve impulse

[Term]
id: GO:0051943
name: positive regulation of amino acid uptake during transmission of nerve impulse
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai]
synonym: "activation of amino acid uptake during transmission of nerve impulse" NARROW []
synonym: "positive regulation of amino acid neurotransmitter reuptake" EXACT []
synonym: "positive regulation of amino acid neurotransmitter uptake" EXACT []
synonym: "stimulation of amino acid uptake during transmission of nerve impulse" NARROW []
synonym: "up regulation of amino acid uptake during transmission of nerve impulse" EXACT []
synonym: "up-regulation of amino acid uptake during transmission of nerve impulse" EXACT []
synonym: "upregulation of amino acid uptake during transmission of nerve impulse" EXACT []
is_a: GO:0051582 ! positive regulation of neurotransmitter uptake
is_a: GO:0051941 ! regulation of amino acid uptake during transmission of nerve impulse
is_a: GO:0051957 ! positive regulation of amino acid transport
relationship: positively_regulates GO:0051933 ! amino acid uptake during transmission of nerve impulse

[Term]
id: GO:0051944
name: positive regulation of catecholamine uptake during transmission of nerve impulse
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai]
synonym: "activation of catecholamine uptake during transmission of nerve impulse" NARROW []
synonym: "positive regulation of catecholamine neurotransmitter reuptake" EXACT []
synonym: "positive regulation of catecholamine neurotransmitter uptake" EXACT []
synonym: "stimulation of catecholamine uptake during transmission of nerve impulse" NARROW []
synonym: "up regulation of catecholamine uptake during transmission of nerve impulse" EXACT []
synonym: "up-regulation of catecholamine uptake during transmission of nerve impulse" EXACT []
synonym: "upregulation of catecholamine uptake during transmission of nerve impulse" EXACT []
is_a: GO:0051582 ! positive regulation of neurotransmitter uptake
is_a: GO:0051940 ! regulation of catecholamine uptake during transmission of nerve impulse
is_a: GO:0051954 ! positive regulation of amine transport
relationship: positively_regulates GO:0051934 ! catecholamine uptake during transmission of nerve impulse

[Term]
id: GO:0051945
name: negative regulation of catecholamine uptake during transmission of nerve impulse
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai]
synonym: "down regulation of catecholamine uptake during transmission of nerve impulse" EXACT []
synonym: "down-regulation of catecholamine uptake during transmission of nerve impulse" EXACT []
synonym: "downregulation of catecholamine uptake during transmission of nerve impulse" EXACT []
synonym: "inhibition of catecholamine uptake during transmission of nerve impulse" NARROW []
synonym: "negative regulation of catecholamine neurotransmitter reuptake" EXACT []
synonym: "negative regulation of catecholamine neurotransmitter uptake" EXACT []
is_a: GO:0051581 ! negative regulation of neurotransmitter uptake
is_a: GO:0051940 ! regulation of catecholamine uptake during transmission of nerve impulse
is_a: GO:0051953 ! negative regulation of amine transport
relationship: negatively_regulates GO:0051934 ! catecholamine uptake during transmission of nerve impulse

[Term]
id: GO:0051946
name: regulation of glutamate uptake during transmission of nerve impulse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai]
synonym: "regulation of glutamate reuptake" EXACT []
synonym: "regulation of L-glutamate reuptake" EXACT []
synonym: "regulation of L-glutamate uptake during transmission of nerve impulse" EXACT []
is_a: GO:0002036 ! regulation of L-glutamate transport
is_a: GO:0051941 ! regulation of amino acid uptake during transmission of nerve impulse
relationship: regulates GO:0051935 ! glutamate uptake during transmission of nerve impulse

[Term]
id: GO:0051947
name: regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai]
synonym: "regulation of 4-aminobutyrate reuptake" EXACT []
synonym: "regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT []
synonym: "regulation of GABA reuptake" EXACT []
synonym: "regulation of GABA uptake during transmission of nerve impulse" EXACT []
synonym: "regulation of gamma-aminobutyric acid reuptake" EXACT []
is_a: GO:0051941 ! regulation of amino acid uptake during transmission of nerve impulse
relationship: regulates GO:0051936 ! gamma-aminobutyric acid uptake during transmission of nerve impulse

[Term]
id: GO:0051948
name: negative regulation of glutamate uptake during transmission of nerve impulse
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai]
synonym: "down regulation of glutamate uptake during transmission of nerve impulse" EXACT []
synonym: "down-regulation of glutamate uptake during transmission of nerve impulse" EXACT []
synonym: "downregulation of glutamate uptake during transmission of nerve impulse" EXACT []
synonym: "inhibition of glutamate uptake during transmission of nerve impulse" NARROW []
synonym: "negative regulation of glutamate reuptake" EXACT []
is_a: GO:0002037 ! negative regulation of L-glutamate transport
is_a: GO:0051942 ! negative regulation of amino acid uptake during transmission of nerve impulse
is_a: GO:0051946 ! regulation of glutamate uptake during transmission of nerve impulse
relationship: negatively_regulates GO:0051935 ! glutamate uptake during transmission of nerve impulse

[Term]
id: GO:0051949
name: negative regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai]
synonym: "down regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
synonym: "down-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
synonym: "downregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
synonym: "inhibition of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW []
synonym: "negative regulation of 4-aminobutyrate reuptake" EXACT []
synonym: "negative regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT []
synonym: "negative regulation of GABA reuptake" EXACT []
synonym: "negative regulation of GABA uptake during transmission of nerve impulse" EXACT []
synonym: "negative regulation of gamma-aminobutyric acid reuptake" EXACT []
is_a: GO:0051942 ! negative regulation of amino acid uptake during transmission of nerve impulse
is_a: GO:0051947 ! regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse
relationship: negatively_regulates GO:0051936 ! gamma-aminobutyric acid uptake during transmission of nerve impulse

[Term]
id: GO:0051950
name: positive regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai]
synonym: "activation of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW []
synonym: "positive regulation of 4-aminobutyrate reuptake" EXACT []
synonym: "positive regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT []
synonym: "positive regulation of GABA reuptake" EXACT []
synonym: "positive regulation of GABA uptake during transmission of nerve impulse" EXACT []
synonym: "positive regulation of gamma-aminobutyric acid reuptake" EXACT []
synonym: "stimulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW []
synonym: "up regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
synonym: "up-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
synonym: "upregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT []
is_a: GO:0051943 ! positive regulation of amino acid uptake during transmission of nerve impulse
is_a: GO:0051947 ! regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse
relationship: positively_regulates GO:0051936 ! gamma-aminobutyric acid uptake during transmission of nerve impulse

[Term]
id: GO:0051951
name: positive regulation of glutamate uptake during transmission of nerve impulse
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai]
synonym: "activation of glutamate uptake during transmission of nerve impulse" NARROW []
synonym: "positive regulation of glutamate reuptake" EXACT []
synonym: "stimulation of glutamate uptake during transmission of nerve impulse" NARROW []
synonym: "up regulation of glutamate uptake during transmission of nerve impulse" EXACT []
synonym: "up-regulation of glutamate uptake during transmission of nerve impulse" EXACT []
synonym: "upregulation of glutamate uptake during transmission of nerve impulse" EXACT []
is_a: GO:0002038 ! positive regulation of L-glutamate transport
is_a: GO:0051943 ! positive regulation of amino acid uptake during transmission of nerve impulse
is_a: GO:0051946 ! regulation of glutamate uptake during transmission of nerve impulse
relationship: positively_regulates GO:0051935 ! glutamate uptake during transmission of nerve impulse

[Term]
id: GO:0051952
name: regulation of amine transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0015837 ! amine transport

[Term]
id: GO:0051953
name: negative regulation of amine transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of amines into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of amine transport" EXACT []
synonym: "down-regulation of amine transport" EXACT []
synonym: "downregulation of amine transport" EXACT []
synonym: "inhibition of amine transport" NARROW []
is_a: GO:0051051 ! negative regulation of transport
is_a: GO:0051952 ! regulation of amine transport
relationship: negatively_regulates GO:0015837 ! amine transport

[Term]
id: GO:0051954
name: positive regulation of amine transport
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
synonym: "activation of amine transport" NARROW []
synonym: "stimulation of amine transport" NARROW []
synonym: "up regulation of amine transport" EXACT []
synonym: "up-regulation of amine transport" EXACT []
synonym: "upregulation of amine transport" EXACT []
is_a: GO:0051050 ! positive regulation of transport
is_a: GO:0051952 ! regulation of amine transport
relationship: positively_regulates GO:0015837 ! amine transport

[Term]
id: GO:0051955
name: regulation of amino acid transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
is_a: GO:0032890 ! regulation of organic acid transport
is_a: GO:0051952 ! regulation of amine transport
relationship: regulates GO:0006865 ! amino acid transport

[Term]
id: GO:0051956
name: negative regulation of amino acid transport
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of amino acids into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
synonym: "down regulation of amino acid transport" EXACT []
synonym: "down-regulation of amino acid transport" EXACT []
synonym: "downregulation of amino acid transport" EXACT []
synonym: "inhibition of amino acid transport" NARROW []
synonym: "negative regulation of amino acid transmembrane transport" EXACT [GOC:mah]
is_a: GO:0032891 ! negative regulation of organic acid transport
is_a: GO:0051953 ! negative regulation of amine transport
is_a: GO:0051955 ! regulation of amino acid transport
relationship: negatively_regulates GO:0006865 ! amino acid transport

[Term]
id: GO:0051957
name: positive regulation of amino acid transport
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai]
synonym: "activation of amino acid transport" NARROW []
synonym: "positive regulation of amino acid transmembrane transport" EXACT [GOC:mah]
synonym: "stimulation of amino acid transport" NARROW []
synonym: "up regulation of amino acid transport" EXACT []
synonym: "up-regulation of amino acid transport" EXACT []
synonym: "upregulation of amino acid transport" EXACT []
is_a: GO:0032892 ! positive regulation of organic acid transport
is_a: GO:0051954 ! positive regulation of amine transport
is_a: GO:0051955 ! regulation of amino acid transport
relationship: positively_regulates GO:0006865 ! amino acid transport

[Term]
id: GO:0051958
name: methotrexate transport
namespace: biological_process
def: "The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase." [GOC:ai]
is_a: GO:0006835 ! dicarboxylic acid transport
is_a: GO:0015893 ! drug transport
is_a: GO:0042886 ! amide transport

[Term]
id: GO:0051959
name: dynein light intermediate chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a light intermediate chain of the dynein complex." [GOC:bf]
is_a: GO:0045502 ! dynein binding

[Term]
id: GO:0051960
name: regulation of nervous system development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0007399 ! nervous system development

[Term]
id: GO:0051961
name: negative regulation of nervous system development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]
synonym: "down regulation of nervous system development" EXACT []
synonym: "down-regulation of nervous system development" EXACT []
synonym: "downregulation of nervous system development" EXACT []
synonym: "inhibition of nervous system development" NARROW []
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051960 ! regulation of nervous system development
relationship: negatively_regulates GO:0007399 ! nervous system development

[Term]
id: GO:0051962
name: positive regulation of nervous system development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai]
synonym: "activation of nervous system development" NARROW []
synonym: "stimulation of nervous system development" NARROW []
synonym: "up regulation of nervous system development" EXACT []
synonym: "up-regulation of nervous system development" EXACT []
synonym: "upregulation of nervous system development" EXACT []
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051960 ! regulation of nervous system development
relationship: positively_regulates GO:0007399 ! nervous system development

[Term]
id: GO:0051963
name: regulation of synaptogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptogenesis, the formation of a synapse." [GOC:ai]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0050807 ! regulation of synapse organization
is_a: GO:0051960 ! regulation of nervous system development
relationship: regulates GO:0007416 ! synapse assembly

[Term]
id: GO:0051964
name: negative regulation of synaptogenesis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptogenesis, the formation of a synapse." [GOC:ai]
synonym: "down regulation of synaptogenesis" EXACT []
synonym: "down-regulation of synaptogenesis" EXACT []
synonym: "downregulation of synaptogenesis" EXACT []
synonym: "inhibition of synaptogenesis" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0051961 ! negative regulation of nervous system development
is_a: GO:0051963 ! regulation of synaptogenesis
relationship: negatively_regulates GO:0007416 ! synapse assembly

[Term]
id: GO:0051965
name: positive regulation of synaptogenesis
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of synaptogenesis, the formation of a synapse." [GOC:ai]
synonym: "activation of synaptogenesis" NARROW []
synonym: "stimulation of synaptogenesis" NARROW []
synonym: "up regulation of synaptogenesis" EXACT []
synonym: "up-regulation of synaptogenesis" EXACT []
synonym: "upregulation of synaptogenesis" EXACT []
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0051962 ! positive regulation of nervous system development
is_a: GO:0051963 ! regulation of synaptogenesis
relationship: positively_regulates GO:0007416 ! synapse assembly

[Term]
id: GO:0051966
name: regulation of synaptic transmission, glutamatergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
is_a: GO:0050804 ! regulation of synaptic transmission
relationship: regulates GO:0035249 ! synaptic transmission, glutamatergic

[Term]
id: GO:0051967
name: negative regulation of synaptic transmission, glutamatergic
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
synonym: "down regulation of synaptic transmission, glutamatergic" EXACT []
synonym: "down-regulation of synaptic transmission, glutamatergic" EXACT []
synonym: "downregulation of synaptic transmission, glutamatergic" EXACT []
synonym: "inhibition of synaptic transmission, glutamatergic" NARROW []
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic
relationship: negatively_regulates GO:0035249 ! synaptic transmission, glutamatergic

[Term]
id: GO:0051968
name: positive regulation of synaptic transmission, glutamatergic
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai]
synonym: "activation of synaptic transmission, glutamatergic" NARROW []
synonym: "stimulation of synaptic transmission, glutamatergic" NARROW []
synonym: "up regulation of synaptic transmission, glutamatergic" EXACT []
synonym: "up-regulation of synaptic transmission, glutamatergic" EXACT []
synonym: "upregulation of synaptic transmission, glutamatergic" EXACT []
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic
relationship: positively_regulates GO:0035249 ! synaptic transmission, glutamatergic

[Term]
id: GO:0051969
name: regulation of transmission of nerve impulse
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0031644 ! regulation of neurological system process
relationship: regulates GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0051970
name: negative regulation of transmission of nerve impulse
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai]
synonym: "down regulation of transmission of nerve impulse" EXACT []
synonym: "down-regulation of transmission of nerve impulse" EXACT []
synonym: "downregulation of transmission of nerve impulse" EXACT []
synonym: "inhibition of transmission of nerve impulse" NARROW []
is_a: GO:0010648 ! negative regulation of cell communication
is_a: GO:0031645 ! negative regulation of neurological system process
is_a: GO:0051969 ! regulation of transmission of nerve impulse
relationship: negatively_regulates GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0051971
name: positive regulation of transmission of nerve impulse
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai]
synonym: "activation of transmission of nerve impulse" NARROW []
synonym: "stimulation of transmission of nerve impulse" NARROW []
synonym: "up regulation of transmission of nerve impulse" EXACT []
synonym: "up-regulation of transmission of nerve impulse" EXACT []
synonym: "upregulation of transmission of nerve impulse" EXACT []
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0031646 ! positive regulation of neurological system process
is_a: GO:0051969 ! regulation of transmission of nerve impulse
relationship: positively_regulates GO:0019226 ! transmission of nerve impulse

[Term]
id: GO:0051972
name: regulation of telomerase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [EC:2.-.-.-, GOC:ai]
synonym: "telomerase regulator" EXACT []
is_a: GO:0051338 ! regulation of transferase activity

[Term]
id: GO:0051973
name: positive regulation of telomerase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [GOC:ai]
synonym: "activation of telomerase activity" NARROW []
synonym: "stimulation of telomerase activity" NARROW []
synonym: "telomerase activator" RELATED []
synonym: "up regulation of telomerase activity" EXACT []
synonym: "up-regulation of telomerase activity" EXACT []
synonym: "upregulation of telomerase activity" EXACT []
is_a: GO:0051347 ! positive regulation of transferase activity
is_a: GO:0051972 ! regulation of telomerase activity

[Term]
id: GO:0051974
name: negative regulation of telomerase activity
namespace: biological_process
def: "Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [GOC:ai]
synonym: "down regulation of telomerase activity" EXACT []
synonym: "down-regulation of telomerase activity" EXACT []
synonym: "downregulation of telomerase activity" EXACT []
synonym: "inhibition of telomerase activity" NARROW []
synonym: "telomerase inhibitor" RELATED []
is_a: GO:0051348 ! negative regulation of transferase activity
is_a: GO:0051972 ! regulation of telomerase activity

[Term]
id: GO:0051975
name: lysine biosynthetic process via alpha-aminoadipate and saccharopine
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine." [MetaCyc:LYSINE-AMINOAD-PWY]
synonym: "lysine biosynthesis via aminoadipic acid and saccharopine" EXACT []
synonym: "lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT []
xref: MetaCyc:LYSINE-AMINOAD-PWY
is_a: GO:0019878 ! lysine biosynthetic process via aminoadipic acid

[Term]
id: GO:0051976
name: lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine." [MetaCyc:PWY-3081]
synonym: "lysine biosynthesis via aminoadipic acid and N2-acetyl-alpha-aminoadipate" EXACT []
synonym: "lysine biosynthetic process via aminoadipic acid and N2-acetyl-alpha-aminoadipate" EXACT []
xref: MetaCyc:PWY-3081
is_a: GO:0019878 ! lysine biosynthetic process via aminoadipic acid

[Term]
id: GO:0051977
name: lysophospholipid transport
namespace: biological_process
def: "The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids." [GOC:ai]
is_a: GO:0015914 ! phospholipid transport

[Term]
id: GO:0051978
name: lysophospholipid transporter activity
namespace: molecular_function
def: "Enables the directed movement of lysophospholipids into, out of, within or between cells. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids." [GOC:ai]
subset: gosubset_prok
is_a: GO:0005548 ! phospholipid transporter activity

[Term]
id: GO:0051979
name: alginic acid acetylation
namespace: biological_process
def: "The addition of O-acetyl ester groups to alginic acid, a linear polymer of D-mannuronate and L-guluronate." [GOC:mlg]
synonym: "alginate acetylation" EXACT []
is_a: GO:0042120 ! alginic acid metabolic process

[Term]
id: GO:0051980
name: iron-nicotianamine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of the iron chelate iron-nicotianamine (Fe-NA) from one side of a membrane to the other." [GOC:ai]
synonym: "Fe-NA chelate transporter activity" EXACT []
is_a: GO:0015603 ! iron chelate transmembrane transporter activity

[Term]
id: GO:0051981
name: copper chelate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a copper chelate from one side of a membrane to the other. A copper chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [http://www.onelook.com]
subset: gosubset_prok
is_a: GO:0005375 ! copper ion transmembrane transporter activity

[Term]
id: GO:0051982
name: copper-nicotianamine transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other." [GOC:ai]
synonym: "Cu-NA chelate transporter activity" EXACT []
is_a: GO:0051981 ! copper chelate transmembrane transporter activity

[Term]
id: GO:0051983
name: regulation of chromosome segregation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromosome segregation, the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0007059 ! chromosome segregation

[Term]
id: GO:0051984
name: positive regulation of chromosome segregation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]
synonym: "activation of chromosome segregation" NARROW []
synonym: "stimulation of chromosome segregation" NARROW []
synonym: "up regulation of chromosome segregation" EXACT []
synonym: "up-regulation of chromosome segregation" EXACT []
synonym: "upregulation of chromosome segregation" EXACT []
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051983 ! regulation of chromosome segregation
relationship: positively_regulates GO:0007059 ! chromosome segregation

[Term]
id: GO:0051985
name: negative regulation of chromosome segregation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome segregation, the process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai]
synonym: "down regulation of chromosome segregation" EXACT []
synonym: "down-regulation of chromosome segregation" EXACT []
synonym: "downregulation of chromosome segregation" EXACT []
synonym: "inhibition of chromosome segregation" NARROW []
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051983 ! regulation of chromosome segregation
relationship: negatively_regulates GO:0007059 ! chromosome segregation

[Term]
id: GO:0051986
name: negative regulation of attachment of spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai]
synonym: "down regulation of attachment of spindle microtubules to kinetochore" EXACT []
synonym: "down-regulation of attachment of spindle microtubules to kinetochore" EXACT []
synonym: "downregulation of attachment of spindle microtubules to kinetochore" EXACT []
synonym: "inhibition of attachment of spindle microtubules to kinetochore" NARROW []
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:0051985 ! negative regulation of chromosome segregation
is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore
relationship: negatively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore

[Term]
id: GO:0051987
name: positive regulation of attachment of spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai]
synonym: "activation of attachment of spindle microtubules to kinetochore" NARROW []
synonym: "stimulation of attachment of spindle microtubules to kinetochore" NARROW []
synonym: "up regulation of attachment of spindle microtubules to kinetochore" EXACT []
synonym: "up-regulation of attachment of spindle microtubules to kinetochore" EXACT []
synonym: "upregulation of attachment of spindle microtubules to kinetochore" EXACT []
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:0051984 ! positive regulation of chromosome segregation
is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore
relationship: positively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore

[Term]
id: GO:0051988
name: regulation of attachment of spindle microtubules to kinetochore
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai]
synonym: "regulation of kinetochore-microtubule attachment" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032880 ! regulation of protein localization
is_a: GO:0051983 ! regulation of chromosome segregation
is_a: GO:0060341 ! regulation of cellular localization
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
relationship: regulates GO:0008608 ! attachment of spindle microtubules to kinetochore

[Term]
id: GO:0051989
name: coproporphyrinogen dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine." [EC:1.3.99.22]
synonym: "coproporphyrinogen III oxidase activity" EXACT [EC:1.3.99.22]
synonym: "coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.22]
synonym: "HemN" RELATED [EC:1.3.99.22]
synonym: "oxygen-independent coproporphyrinogen-III oxidase activity" EXACT []
synonym: "radical SAM enzyme activity" RELATED [EC:1.3.99.22]
xref: EC:1.3.99.22
xref: MetaCyc:HEMN-RXN
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0051990
name: (R)-2-hydroxyglutarate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN]
subset: gosubset_prok
synonym: "D-2-hydroxyglutarate dehydrogenase activity" EXACT []
xref: EC:1.1.1.-
is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors

[Term]
id: GO:0052000
name: Type IV pili-dependent aggregation
namespace: biological_process
def: "The formation of bacterial aggregates in liquid culture dependent on the presence of Type IV pili." [GOC:ml]
subset: gosubset_prok
synonym: "auto-aggregation" BROAD []
synonym: "bfp-dependent aggregation" EXACT []
synonym: "bundle-forming fimbriae-dependent aggregation" EXACT []
synonym: "bundle-forming pili-dependent aggregation" EXACT []
synonym: "tfp-dependent aggregation" EXACT []
is_a: GO:0016337 ! cell-cell adhesion

[Term]
id: GO:0052001
name: Type IV pili-dependent localized adherence to host
namespace: biological_process
def: "Attachment of bacterial clusters to the surface of the host in a type IV pili dependent manner. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml]
subset: gosubset_prok
is_a: GO:0044406 ! adhesion to host

[Term]
id: GO:0052002
name: metabolism by symbiont of substance in host
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0052214 ! metabolism of substance in other organism during symbiotic interaction

[Term]
id: GO:0052003
name: negative regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "down-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "downregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "inhibition by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "negative modulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT []
synonym: "negative modulation by organism of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT []
is_a: GO:0052004 ! negative regulation by symbiont of host salicylic acid-mediated defense response
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway
is_a: GO:0052081 ! modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway
is_a: GO:0052252 ! negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction

[Term]
id: GO:0052004
name: negative regulation by symbiont of host salicylic acid-mediated defense response
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host salicylic acid-mediated defense response" EXACT []
synonym: "down-regulation by symbiont of host salicylic acid-mediated defense response" EXACT []
synonym: "downregulation by symbiont of host salicylic acid-mediated defense response" EXACT []
synonym: "inhibition by symbiont of host salicylic acid-mediated defense response" NARROW []
synonym: "negative regulation of host SA-mediated defense response" EXACT []
synonym: "suppression by organism of host salicylic acid-mediated defense response" EXACT []
synonym: "suppression of host SA mediated defense response" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052089 ! modulation by symbiont of host salicylic acid-mediated defense response
is_a: GO:0052253 ! negative regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction
relationship: negatively_regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway

[Term]
id: GO:0052005
name: negative regulation by symbiont of host ethylene-mediated defense response
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "down-regulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "downregulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "inhibition by symbiont of host ethylene-mediated defense response" NARROW []
synonym: "suppression by organism of host ethylene-mediated defense response" EXACT []
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052084 ! modulation by symbiont of host ethylene-mediated defense response
is_a: GO:0052254 ! negative regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction

[Term]
id: GO:0052006
name: catabolism by symbiont of substance in host
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in its host resulting in the breakdown of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of substance in host" EXACT []
is_a: GO:0052002 ! metabolism by symbiont of substance in host
is_a: GO:0052227 ! catabolism of substance in other organism during symbiotic interaction

[Term]
id: GO:0052007
name: biosynthesis by symbiont of substance in host
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in its host resulting in the formation of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "biosynthesis by organism of substance in host" EXACT []
is_a: GO:0052002 ! metabolism by symbiont of substance in host
is_a: GO:0052226 ! biosynthesis of substance in other organism during symbiotic interaction

[Term]
id: GO:0052008
name: disassembly by symbiont of host cellular component
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "catabolism of host cellular component by organism" EXACT []
synonym: "catabolism of host structural constituent by organism" EXACT []
synonym: "degradation of host cellular component by organism" EXACT []
synonym: "disassembly by organism of host cellular component" EXACT []
is_a: GO:0052043 ! modification by symbiont of host cellular component
is_a: GO:0052368 ! disassembly by organism of cellular component in other organism during symbiotic interaction

[Term]
id: GO:0052009
name: disassembly by symbiont of host cell wall
namespace: biological_process
def: "The breakdown of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "catabolism of host cell wall by organism" EXACT []
synonym: "degradation of host cell wall by organism" EXACT []
synonym: "disassembly by organism of host cell wall" EXACT []
is_a: GO:0052008 ! disassembly by symbiont of host cellular component
is_a: GO:0052020 ! modification by symbiont of host cell wall
is_a: GO:0052339 ! disassembly by organism of cell wall of other organism during symbiotic interaction

[Term]
id: GO:0052010
name: catabolism by symbiont of host cell wall cellulose
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "catabolism by organism of host cell wall cellulose" EXACT []
is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate
is_a: GO:0052172 ! metabolism by symbiont of host cell wall cellulose
is_a: GO:0052340 ! catabolism by organism of cell wall cellulose in other organism during symbiotic interaction
relationship: part_of GO:0052009 ! disassembly by symbiont of host cell wall

[Term]
id: GO:0052011
name: catabolism by symbiont of host cell wall pectin
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "catabolism by organism of host cell wall pectin" EXACT []
is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate
is_a: GO:0052179 ! metabolism by symbiont of host cell wall pectin
is_a: GO:0052341 ! catabolism by organism of cell wall pectin in other organism during symbiotic interaction
relationship: part_of GO:0052009 ! disassembly by symbiont of host cell wall

[Term]
id: GO:0052012
name: catabolism by symbiont of host cell wall chitin
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "catabolism by organism of host cell wall chitin" EXACT []
is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate
is_a: GO:0052178 ! metabolism by symbiont of host cell wall chitin
is_a: GO:0052342 ! catabolism by organism of cell wall chitin in other organism during symbiotic interaction
relationship: part_of GO:0052009 ! disassembly by symbiont of host cell wall

[Term]
id: GO:0052013
name: catabolism by symbiont of host macromolecule
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of host macromolecule" EXACT []
is_a: GO:0052006 ! catabolism by symbiont of substance in host
is_a: GO:0052174 ! metabolism by symbiont of host macromolecule
is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism during symbiotic interaction

[Term]
id: GO:0052014
name: catabolism by symbiont of host protein
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of host protein" EXACT []
is_a: GO:0052013 ! catabolism by symbiont of host macromolecule
is_a: GO:0052228 ! metabolism by symbiont of host protein
is_a: GO:0052363 ! catabolism by organism of protein in other organism during symbiotic interaction

[Term]
id: GO:0052015
name: catabolism by symbiont of host carbohydrate
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of host carbohydrate" EXACT []
is_a: GO:0052013 ! catabolism by symbiont of host macromolecule
is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate
is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism during symbiotic interaction

[Term]
id: GO:0052016
name: catabolism by symbiont of host glucan
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of host glucan" EXACT []
is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate
is_a: GO:0052176 ! metabolism by symbiont of host glucan
is_a: GO:0052359 ! catabolism by organism of glucan in other organism during symbiotic interaction

[Term]
id: GO:0052017
name: catabolism by symbiont of host xylan
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism by organism of host xylan" EXACT []
is_a: GO:0052015 ! catabolism by symbiont of host carbohydrate
is_a: GO:0052177 ! metabolism by symbiont of host xylan
is_a: GO:0052366 ! catabolism by organism of xylan in other organism during symbiotic interaction

[Term]
id: GO:0052018
name: modulation by symbiont of RNA levels in host
namespace: biological_process
def: "The alteration by an organism of the levels of RNA in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by symbiont of host RNA levels" EXACT []
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0052249 ! modulation of RNA levels in other organism during symbiotic interaction

[Term]
id: GO:0052019
name: modulation by symbiont of host hormone or growth regulator levels
namespace: biological_process
def: "The alteration by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction

[Term]
id: GO:0052020
name: modification by symbiont of host cell wall
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "metabolism of host cell wall by organism" EXACT []
is_a: GO:0052043 ! modification by symbiont of host cellular component
is_a: GO:0052333 ! modification by organism of cell wall of other organism during symbiotic interaction

[Term]
id: GO:0052021
name: modulation by symbiont of ethylene levels in host
namespace: biological_process
def: "The alteration by an organism of the levels of ethylene in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels
is_a: GO:0052449 ! modulation by organism of ethylene levels in other organism during symbiotic interaction

[Term]
id: GO:0052022
name: modulation by symbiont of jasmonic acid levels in host
namespace: biological_process
def: "The alteration by an organism of the levels of jasmonic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels
is_a: GO:0052456 ! modulation by organism of jasmonic acid levels in other organism during symbiotic interaction

[Term]
id: GO:0052023
name: modulation by symbiont of salicylic acid levels in host
namespace: biological_process
def: "The alteration by an organism of the levels of salicylic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels
is_a: GO:0052469 ! modulation by organism of salicylic acid levels in other organism during symbiotic interaction

[Term]
id: GO:0052024
name: positive regulation by symbiont of hormone or growth regulator levels in host
namespace: biological_process
def: "The increase by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of hormone or growth regulator levels in host" NARROW []
synonym: "positive modulation of hormone or growth regulator levels in host" EXACT []
synonym: "stimulation by symbiont of hormone or growth regulator levels in host" NARROW []
synonym: "up regulation by symbiont of hormone or growth regulator levels in host" EXACT []
synonym: "up-regulation by symbiont of hormone or growth regulator levels in host" EXACT []
synonym: "upregulation by symbiont of hormone or growth regulator levels in host" EXACT []
is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels
is_a: GO:0052513 ! positive regulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction

[Term]
id: GO:0052025
name: modification by symbiont of host cell membrane
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of the host cell membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052043 ! modification by symbiont of host cellular component
is_a: GO:0052332 ! modification by organism of cell membrane in other organism during symbiotic interaction

[Term]
id: GO:0052026
name: modulation by symbiont of host transcription
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of host transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0052312 ! modulation of transcription in other organism during symbiotic interaction

[Term]
id: GO:0052027
name: modulation by symbiont of host signal transduction pathway
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by symbiont of host signal transduction" RELATED []
synonym: "modulation of host signal transduction by symbiont" EXACT []
synonym: "regulation by symbiont of host signal transduction pathway" EXACT []
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0052250 ! modulation of signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052028
name: positive regulation by symbiont of host signal transduction pathway
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host signal transduction pathway" NARROW []
synonym: "stimulation by symbiont of host signal transduction pathway" NARROW []
synonym: "up regulation by symbiont of host signal transduction pathway" EXACT []
synonym: "up-regulation by symbiont of host signal transduction pathway" EXACT []
synonym: "upregulation by symbiont of host signal transduction pathway" EXACT []
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway
is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052029
name: negative regulation by symbiont of host signal transduction pathway
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host signal transduction pathway" EXACT []
synonym: "down-regulation by symbiont of host signal transduction pathway" EXACT []
synonym: "downregulation by symbiont of host signal transduction pathway" EXACT []
synonym: "inhibition by symbiont of host signal transduction pathway" NARROW []
synonym: "negative modulation by organism of host signal transduction pathway" EXACT []
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway
is_a: GO:0052493 ! negative regulation by organism of signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052030
name: induction by symbiont of host apoptosis
namespace: biological_process
def: "Any process by which an organism activates programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of host apoptosis" EXACT []
synonym: "activation by organism of host apoptotic programmed cell death" EXACT []
synonym: "induction by organism of host apoptotic programmed cell death" EXACT []
is_a: GO:0052044 ! induction by symbiont of host programmed cell death
is_a: GO:0052151 ! positive regulation by symbiont of host apoptosis
is_a: GO:0052388 ! induction by organism of apoptosis in other organism during symbiotic interaction

[Term]
id: GO:0052031
name: modulation by symbiont of host defense response
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the defense response of its host, the response mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0052200 ! response to host defenses
is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052032
name: modulation by symbiont of host inflammatory response
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052256 ! modulation by organism of inflammatory response of other organism during symbiotic interaction

[Term]
id: GO:0052033
name: pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity
namespace: biological_process
subset: gosubset_prok
synonym: "general elicitor-dependent activation of host innate immunity" EXACT []
synonym: "general elicitor-dependent induction of host innate immunity" EXACT []
synonym: "MAMP dependent activation of host innate immunity" EXACT []
synonym: "MAMP dependent induction of host innate immunity" EXACT []
synonym: "PAMP dependent activation of host innate immunity" EXACT []
synonym: "PAMP dependent induction of host innate immunity" EXACT []
synonym: "pathogen-associated molecular pattern dependent activation by organism of host innate immunity" EXACT []
is_a: GO:0052166 ! positive regulation by symbiont of host innate immunity
is_a: GO:0052169 ! pathogen-associated molecular pattern dependent modulation by symbiont of host innate immunity
is_a: GO:0052257 ! pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism during symbiotic interaction

[Term]
id: GO:0052034
name: negative regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity
namespace: biological_process
subset: gosubset_prok
synonym: "down regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" EXACT []
synonym: "down-regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" EXACT []
synonym: "downregulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" EXACT []
synonym: "inhibition by symbiont of pathogen-associated molecular pattern-induced host innate immunity" NARROW []
synonym: "suppression of general elicitor induced host innate immunity" EXACT []
synonym: "suppression of general elicitor-induced host innate immunity" EXACT []
synonym: "suppression of MAMP induced host innate immunity" EXACT []
synonym: "suppression of MAMP-induced host innate immunity" EXACT []
synonym: "suppression of PAMP induced host innate immunity" EXACT []
synonym: "suppression of PAMP-induced host innate immunity" EXACT []
synonym: "suppression of pathogen-associated molecular pattern-induced host innate immunity" EXACT []
is_a: GO:0052157 ! modulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity
is_a: GO:0052170 ! negative regulation by symbiont of host innate immunity
is_a: GO:0052258 ! negative regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction

[Term]
id: GO:0052035
name: positive regulation by symbiont of host inflammatory response
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host inflammatory response" NARROW []
synonym: "stimulation by symbiont of host inflammatory response" NARROW []
synonym: "up regulation by symbiont of host inflammatory response" EXACT []
synonym: "up-regulation by symbiont of host inflammatory response" EXACT []
synonym: "upregulation by symbiont of host inflammatory response" EXACT []
is_a: GO:0052032 ! modulation by symbiont of host inflammatory response
is_a: GO:0052259 ! positive regulation by organism of inflammatory response of other organism during symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response

[Term]
id: GO:0052036
name: negative regulation by symbiont of host inflammatory response
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host inflammatory response" EXACT []
synonym: "down-regulation by symbiont of host inflammatory response" EXACT []
synonym: "downregulation by symbiont of host inflammatory response" EXACT []
synonym: "inhibition by symbiont of host inflammatory response" NARROW []
is_a: GO:0052032 ! modulation by symbiont of host inflammatory response
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052260 ! negative regulation by organism of inflammatory response of other organism during symbiotic interaction

[Term]
id: GO:0052037
name: negative regulation by symbiont of host defense response
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host defense response" EXACT []
synonym: "down-regulation by symbiont of host defense response" EXACT []
synonym: "downregulation by symbiont of host defense response" EXACT []
synonym: "inhibition by symbiont of host defense response" NARROW []
synonym: "suppression of host defense response" EXACT []
is_a: GO:0044414 ! suppression of host defenses
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052038
name: modulation by symbiont of host intracellular transport
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of host intracellular trafficking" EXACT []
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0052230 ! modulation of intracellular transport in other organism during symbiotic interaction

[Term]
id: GO:0052039
name: modification by symbiont of host cytoskeleton
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of the host cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052043 ! modification by symbiont of host cellular component
is_a: GO:0052334 ! modification by organism of cytoskeleton of other organism during symbiotic interaction

[Term]
id: GO:0052040
name: modulation by symbiont of host programmed cell death
namespace: biological_process
alt_id: GO:0052152
def: "Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by symbiont of host non-apoptotic programmed cell death" NARROW []
synonym: "modulation of host PCD" EXACT []
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0052248 ! modulation of programmed cell death in other organism during symbiotic interaction

[Term]
id: GO:0052041
name: negative regulation by symbiont of host programmed cell death
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host programmed cell death" EXACT []
synonym: "down-regulation by symbiont of host programmed cell death" EXACT []
synonym: "downregulation by symbiont of host programmed cell death" EXACT []
synonym: "inhibition by symbiont of host programmed cell death" NARROW []
synonym: "inhibition of host programmed cell death" EXACT []
synonym: "suppression by symbiont of host PCD" EXACT []
synonym: "suppression by symbiont of host programmed cell death" EXACT []
is_a: GO:0052040 ! modulation by symbiont of host programmed cell death
is_a: GO:0052490 ! negative regulation by organism of programmed cell death in other organism during symbiotic interaction

[Term]
id: GO:0052042
name: positive regulation by symbiont of host programmed cell death
namespace: biological_process
alt_id: GO:0052153
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host programmed cell death" NARROW []
synonym: "enhancement of host programmed cell death" EXACT []
synonym: "positive regulation by symbiont of host non-apoptotic programmed cell death" NARROW []
synonym: "stimulation by symbiont of host programmed cell death" NARROW []
is_a: GO:0052040 ! modulation by symbiont of host programmed cell death
is_a: GO:0052330 ! positive regulation by organism of programmed cell death in other organism during symbiotic interaction
relationship: part_of GO:0001907 ! killing by symbiont of host cells

[Term]
id: GO:0052043
name: modification by symbiont of host cellular component
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of a host cellular component. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052111 ! modification by symbiont of host structure
is_a: GO:0052188 ! modification of cellular component in other organism during symbiotic interaction

[Term]
id: GO:0052044
name: induction by symbiont of host programmed cell death
namespace: biological_process
def: "The activation by an organism of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of host programmed cell death" EXACT []
is_a: GO:0052400 ! induction by organism of programmed cell death in other organism during symbiotic interaction

[Term]
id: GO:0052045
name: upregulation by symbiont of host programmed cell death
namespace: biological_process
def: "Any process by which an organism increases the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "enhancement of host programmed cell death by organism" EXACT []
is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death
is_a: GO:0052529 ! upregulation by organism of programmed cell death in other organism during symbiotic interaction

[Term]
id: GO:0052046
name: modification by symbiont of host morphology or physiology via secreted substance
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by one of the organisms. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modification of host morphology or physiology via effector molecule" NARROW []
synonym: "modification of host morphology or physiology via ellicitor" NARROW []
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0052048 ! interaction with host via secreted substance during symbiotic interaction
is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance during symbiotic interaction

[Term]
id: GO:0052047
name: interaction with other organism via secreted substance during symbiotic interaction
namespace: biological_process
def: "An interaction with a second organism mediated by a substance secreted by the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044419 ! interspecies interaction between organisms
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0052048
name: interaction with host via secreted substance during symbiotic interaction
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044046 ! interaction with host via substance released outside of symbiont
is_a: GO:0052047 ! interaction with other organism via secreted substance during symbiotic interaction

[Term]
id: GO:0052049
name: interaction with host via protein secreted by type III secretion system
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the symbiont organism by a type III secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052048 ! interaction with host via secreted substance during symbiotic interaction
is_a: GO:0052210 ! interaction with other organism via protein secreted by type III secretion system during symbiotic interaction

[Term]
id: GO:0052050
name: interaction with host via substance secreted by type IV secretion system
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the other organism by a type IV secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052048 ! interaction with host via secreted substance during symbiotic interaction
is_a: GO:0052209 ! interaction with other organism via substance secreted by type IV secretion system during symbiotic interaction

[Term]
id: GO:0052051
name: interaction with host via protein secreted by type II secretion system
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the other organism by a type II secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052048 ! interaction with host via secreted substance during symbiotic interaction
is_a: GO:0052211 ! interaction with other organism via protein secreted by type II secretion system during symbiotic interaction

[Term]
id: GO:0052052
name: modification by symbiont of host morphology or physiology via protein secreted by type II secretion system
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type II secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance
is_a: GO:0052051 ! interaction with host via protein secreted by type II secretion system
is_a: GO:0052206 ! modification of morphology or physiology of other organism via protein secreted by type II secretion system during symbiotic interaction

[Term]
id: GO:0052053
name: negative regulation by symbiont of host catalytic activity
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host enzyme activity" EXACT []
synonym: "down-regulation by symbiont of host enzyme activity" EXACT []
synonym: "downregulation by symbiont of host enzyme activity" EXACT []
synonym: "inhibition by symbiont of host enzyme activity" NARROW []
synonym: "inhibition of host enzyme activity" EXACT []
synonym: "negative regulation by symbiont of host enzyme activity" EXACT []
is_a: GO:0052056 ! negative regulation by symbiont of host molecular function
is_a: GO:0052148 ! modulation by symbiont of host catalytic activity
is_a: GO:0052199 ! negative regulation of catalytic activity in other organism during symbiotic interaction

[Term]
id: GO:0052054
name: negative regulation by symbiont of host peptidase activity
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "down regulation by symbiont of host protease activity" EXACT []
synonym: "down-regulation by symbiont of host protease activity" EXACT []
synonym: "downregulation by symbiont of host protease activity" EXACT []
synonym: "inhibition by symbiont of host protease activity" NARROW []
synonym: "inhibition of host protease activity" EXACT []
synonym: "negative regulation by symbiont of host protease activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0052053 ! negative regulation by symbiont of host catalytic activity
is_a: GO:0052149 ! modulation by symbiont of host protease activity
is_a: GO:0052180 ! negative regulation of peptidase activity in other organism during symbiotic interaction

[Term]
id: GO:0052055
name: modulation by symbiont of host molecular function
namespace: biological_process
def: "The process by which an organism effects a change in the function of a host protein via a direct interaction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "modification by symbiont of host molecular function" EXACT []
synonym: "modification by symbiont of host protein function" EXACT [GOC:dph, GOC:tb]
is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance
is_a: GO:0052205 ! modulation of molecular function in other organism during symbiotic interaction

[Term]
id: GO:0052056
name: negative regulation by symbiont of host molecular function
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the functional activity of host proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "down regulation by symbiont of host protein function" EXACT []
synonym: "down-regulation by symbiont of host protein function" EXACT []
synonym: "downregulation by symbiont of host protein function" EXACT []
synonym: "inhibition by symbiont of host protein function" NARROW []
synonym: "inhibition of host protein function" EXACT []
synonym: "negative regulation by symbiont of host protein function" EXACT [GOC:dph, GOC:tb]
is_a: GO:0052055 ! modulation by symbiont of host molecular function
is_a: GO:0052204 ! negative regulation of molecular function in other organism during symbiotic interaction

[Term]
id: GO:0052057
name: modification by symbiont of host morphology or physiology via protein secreted by type III secretion system
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type III secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance
is_a: GO:0052049 ! interaction with host via protein secreted by type III secretion system
is_a: GO:0052207 ! modification of morphology or physiology of other organism via protein secreted by type III secretion system during symbiotic interaction

[Term]
id: GO:0052058
name: modification by symbiont of host morphology or physiology via substance secreted by type IV secretion system
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type IV secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052046 ! modification by symbiont of host morphology or physiology via secreted substance
is_a: GO:0052050 ! interaction with host via substance secreted by type IV secretion system
is_a: GO:0052208 ! modification of morphology or physiology of other organism via substance secreted by type IV secretion system during symbiotic interaction

[Term]
id: GO:0052059
name: evasion or tolerance by symbiont of host-produced reactive oxygen species
namespace: biological_process
def: "The process by which an organism avoids the effects of reactive oxygen species produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "evasion by organism of cellular damage caused by host oxidative burst" NARROW []
synonym: "evasion or tolerance by organism of host-produced reactive oxygen species" EXACT []
synonym: "evasion or tolerance by organism of reactive oxygen species produced during host defense response" EXACT []
synonym: "evasion or tolerance of defense-related host metabolic burst" EXACT []
synonym: "evasion or tolerance of defense-related host oxidative burst" EXACT []
synonym: "evasion or tolerance of defense-related host respiratory burst" EXACT []
synonym: "evasion or tolerance of host-produced active oxygen species" EXACT []
synonym: "evasion or tolerance of host-produced AOS" EXACT []
synonym: "evasion or tolerance of host-produced reactive oxygen intermediates" EXACT []
synonym: "evasion or tolerance of host-produced ROIs" EXACT []
synonym: "evasion or tolerance of host-produced ROS" EXACT []
synonym: "evasion or tolerance of reactive oxygen species produced by host in response to organism" EXACT []
is_a: GO:0020012 ! evasion or tolerance of host immune response
is_a: GO:0052385 ! evasion or tolerance by organism of reactive oxygen species produced by other organism during symbiotic interaction
is_a: GO:0052567 ! response to defense-related host reactive oxygen species production

[Term]
id: GO:0052060
name: evasion or tolerance by symbiont of host-produced nitric oxide
namespace: biological_process
def: "The process by which an organism avoids the effects of nitric oxide produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "evasion or tolerance by organism of host nitric oxide" EXACT []
synonym: "evasion or tolerance by organism of host NO" EXACT []
synonym: "evasion or tolerance by organism of host-produced nitric oxide" EXACT []
synonym: "evasion or tolerance by organism of host-produced NO" EXACT []
synonym: "evasion or tolerance of nitric oxide produced by host in response to organism" EXACT []
synonym: "evasion or tolerance of NO produced by host in response to organism" EXACT []
is_a: GO:0020012 ! evasion or tolerance of host immune response
is_a: GO:0052376 ! evasion or tolerance by organism of nitric oxide produced by other organism during symbiotic interaction
is_a: GO:0052565 ! response to defense-related host nitric oxide production

[Term]
id: GO:0052061
name: evasion or tolerance by symbiont of host-produced phytoalexins
namespace: biological_process
def: "The process by which an organism avoids the effects of phytoalexins produced as a defense response by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "evasion or tolerance by organism of host phytoalexins" EXACT []
synonym: "evasion or tolerance by organism of host-produced phytoalexins" EXACT []
synonym: "evasion or tolerance of phytoalexins produced by host in response to organism" EXACT []
synonym: "host phytoalexin detoxification" NARROW []
is_a: GO:0020012 ! evasion or tolerance of host immune response
is_a: GO:0052378 ! evasion or tolerance by organism of phytoalexins produced by other organism during symbiotic interaction
is_a: GO:0052566 ! response to host phytoalexin production

[Term]
id: GO:0052062
name: induction by symbiont of host phytoalexin production
namespace: biological_process
def: "The activation by an organism of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of host phytoalexin production" EXACT []
is_a: GO:0052262 ! induction by organism of phytoalexin production in other organism during symbiotic interaction
is_a: GO:0052344 ! positive regulation by symbiont of host phytoalexin production
is_a: GO:0052559 ! induction by symbiont of host immune response

[Term]
id: GO:0052063
name: induction by symbiont of defense-related host nitric oxide production
namespace: biological_process
def: "The activation by an organism of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related host nitric oxide production" EXACT []
synonym: "activation by organism of defense-related host NO production" EXACT []
synonym: "induction by organism of defense-related host NO production" EXACT []
is_a: GO:0052263 ! induction by organism of defense-related nitric oxide production in other organism during symbiotic interaction
is_a: GO:0052347 ! positive regulation by symbiont of defense-related host nitric oxide production
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:0052559 ! induction by symbiont of host immune response

[Term]
id: GO:0052064
name: induction by symbiont of defense-related host reactive oxygen species production
namespace: biological_process
def: "The activation by an organism of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related host active oxygen species production" EXACT []
synonym: "activation by organism of defense-related host AOS production" EXACT []
synonym: "activation by organism of defense-related host metabolic burst" EXACT []
synonym: "activation by organism of defense-related host oxidative burst" EXACT []
synonym: "activation by organism of defense-related host reactive oxidative species production" EXACT []
synonym: "activation by organism of defense-related host reactive oxygen intermediate production" EXACT []
synonym: "activation by organism of defense-related host reactive oxygen species production" EXACT []
synonym: "activation by organism of defense-related host respiratory burst" EXACT []
synonym: "activation by organism of defense-related host ROI production" EXACT []
synonym: "activation by organism of defense-related host ROS production" EXACT []
synonym: "induction by organism of defense-related host active oxygen species production" EXACT []
synonym: "induction by organism of defense-related host AOS production" EXACT []
synonym: "induction by organism of defense-related host metabolic burst" EXACT []
synonym: "induction by organism of defense-related host oxidative burst" EXACT []
synonym: "induction by organism of defense-related host reactive oxidative species production" EXACT []
synonym: "induction by organism of defense-related host reactive oxygen intermediate production" EXACT []
synonym: "induction by organism of defense-related host respiratory burst" EXACT []
synonym: "induction by organism of defense-related host ROI production" EXACT []
synonym: "induction by organism of defense-related host ROS production" EXACT []
is_a: GO:0052264 ! induction by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction
is_a: GO:0052369 ! positive regulation by symbiont of defense-related host reactive oxygen species production
is_a: GO:0052559 ! induction by symbiont of host immune response

[Term]
id: GO:0052065
name: positive regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of defense-related Ca2+ flux in other organism during symbiotic interaction" RELATED []
synonym: "stimulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" EXACT []
is_a: GO:0052301 ! modulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052066
name: entry of symbiont into host cell by promotion of host phagocytosis
namespace: biological_process
def: "The invasion by an organism of a cell of its host organism by utilizing the host phagocytosis mechanism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "entry of organism into host cell by promotion of host phagocytosis" EXACT []
is_a: GO:0030260 ! entry into host cell
is_a: GO:0052191 ! positive regulation by symbiont of host phagocytosis
is_a: GO:0052370 ! entry of organism into cell of other organism by promotion of phagocytosis in other organism during symbiotic interaction

[Term]
id: GO:0052067
name: negative regulation by symbiont of entry into host cell via phagocytosis
namespace: biological_process
def: "Any process by which an organism stops or prevents itself undergoing phagocytosis into a cell in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by symbiont of entry into host cell via phagocytosis" EXACT []
synonym: "down-regulation by symbiont of entry into host cell via phagocytosis" EXACT []
synonym: "downregulation by symbiont of entry into host cell via phagocytosis" EXACT []
synonym: "inhibition by symbiont of entry into host cell via phagocytosis" NARROW []
synonym: "negative regulation by organism of entry into host cell via host phagocytosis" EXACT []
is_a: GO:0044415 ! evasion or tolerance of host defenses
is_a: GO:0052374 ! negative regulation by symbiont of entry into host
is_a: GO:0052380 ! modulation by symbiont of entry into host via phagocytosis
is_a: GO:0052483 ! negative regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction

[Term]
id: GO:0052068
name: negative regulation by symbiont of host jasmonic acid-mediated defense response
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host jasmonic acid-mediated defense response" EXACT []
synonym: "down-regulation by symbiont of host jasmonic acid-mediated defense response" EXACT []
synonym: "downregulation by symbiont of host jasmonic acid-mediated defense response" EXACT []
synonym: "inhibition by symbiont of host jasmonic acid-mediated defense response" NARROW []
synonym: "suppression by organism of host JA-mediated defense response" EXACT []
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052088 ! modulation by symbiont of host jasmonic acid-mediated defense response
is_a: GO:0052266 ! negative regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction
is_a: GO:0052562 ! negative regulation by symbiont of host immune response

[Term]
id: GO:0052069
name: negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host jasmonic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT []
synonym: "down-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT []
synonym: "downregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT []
synonym: "inhibition by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "negative regulation by organism of defense-related host JA-mediated signal transduction pathway" EXACT []
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway
is_a: GO:0052068 ! negative regulation by symbiont of host jasmonic acid-mediated defense response
is_a: GO:0052082 ! modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway
is_a: GO:0052267 ! negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052070
name: negative regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host ethylene-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT []
synonym: "down-regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT []
synonym: "downregulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT []
synonym: "inhibition by symbiont of defense-related host ethylene-mediated signal transduction pathway" NARROW []
synonym: "suppression by organism of defense-related host ethylene-mediated signal transduction pathway" EXACT []
is_a: GO:0052005 ! negative regulation by symbiont of host ethylene-mediated defense response
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway
is_a: GO:0052077 ! modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway
is_a: GO:0052268 ! negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052071
name: positive regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of host ethylene-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related host ethylene-mediated signal transduction pathway" NARROW []
synonym: "activation by symbiont of defense-related host ethylene-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related host ethylene-mediated signal transduction pathway" NARROW []
synonym: "stimulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" NARROW []
synonym: "up regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT []
synonym: "up-regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related host ethylene-mediated signal transduction pathway" NARROW []
synonym: "upregulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" EXACT []
is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway
is_a: GO:0052076 ! positive regulation by symbiont of host ethylene-mediated defense response
is_a: GO:0052077 ! modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway
is_a: GO:0052269 ! positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052072
name: positive regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "activation by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "activation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "stimulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "up regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "up-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "upregulation by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "upregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT []
is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway
is_a: GO:0052074 ! positive regulation by symbiont of host salicylic acid-mediated defense response
is_a: GO:0052081 ! modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway
is_a: GO:0052270 ! positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052073
name: positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of host jasmonic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "activation by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "activation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT []
synonym: "stimulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "up regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT []
synonym: "up-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "upregulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW []
synonym: "upregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" EXACT []
is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway
is_a: GO:0052075 ! positive regulation by symbiont of host jasmonic acid-mediated defense response
is_a: GO:0052082 ! modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway
is_a: GO:0052271 ! positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052074
name: positive regulation by symbiont of host salicylic acid-mediated defense response
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host salicylic acid-mediated defense response" NARROW []
synonym: "induction by organism of host SA-mediated defense response" NARROW []
synonym: "induction by organism of host salicylic acid-mediated defense response" NARROW []
synonym: "positive regulation by organism of host SA-mediated defense response" EXACT []
synonym: "stimulation by symbiont of host salicylic acid-mediated defense response" NARROW []
synonym: "up regulation by symbiont of host salicylic acid-mediated defense response" EXACT []
synonym: "up-regulation by symbiont of host salicylic acid-mediated defense response" EXACT []
synonym: "upregulation by symbiont of host salicylic acid-mediated defense response" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0052089 ! modulation by symbiont of host salicylic acid-mediated defense response
is_a: GO:0052272 ! positive regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
relationship: positively_regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway

[Term]
id: GO:0052075
name: positive regulation by symbiont of host jasmonic acid-mediated defense response
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host jasmonic acid-mediated defense response" NARROW []
synonym: "induction by organism of host JA-mediated defense response" NARROW []
synonym: "induction by organism of host jasmonic acid-mediated defense response" NARROW []
synonym: "positive regulation by organism of host JA-mediated defense response" EXACT []
synonym: "stimulation by symbiont of host jasmonic acid-mediated defense response" NARROW []
synonym: "up regulation by symbiont of host jasmonic acid-mediated defense response" EXACT []
synonym: "up-regulation by symbiont of host jasmonic acid-mediated defense response" EXACT []
synonym: "upregulation by symbiont of host jasmonic acid-mediated defense response" EXACT []
is_a: GO:0052088 ! modulation by symbiont of host jasmonic acid-mediated defense response
is_a: GO:0052273 ! positive regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:0052556 ! positive regulation by symbiont of host immune response

[Term]
id: GO:0052076
name: positive regulation by symbiont of host ethylene-mediated defense response
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of host ethylene-mediated defense response" NARROW []
synonym: "activation by symbiont of host ethylene-mediated defense response" NARROW []
synonym: "induction by organism of host ethylene-mediated defense response" NARROW []
synonym: "stimulation by symbiont of host ethylene-mediated defense response" NARROW []
synonym: "up regulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "up-regulation by symbiont of host ethylene-mediated defense response" EXACT []
synonym: "upregulation by organism of host ethylene-mediated defense response" NARROW []
synonym: "upregulation by symbiont of host ethylene-mediated defense response" EXACT []
is_a: GO:0052084 ! modulation by symbiont of host ethylene-mediated defense response
is_a: GO:0052274 ! positive regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response

[Term]
id: GO:0052077
name: modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of host ethylene-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052441 ! modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052078
name: negative regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "down-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "downregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "inhibition by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "negative regulation by organism of defense-related host MAPK-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway" EXACT []
synonym: "suppression by organism of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052080 ! modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway
is_a: GO:0052275 ! negative regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction
is_a: GO:0075132 ! negative regulation by symbiont of host protein kinase-mediated signal transduction

[Term]
id: GO:0052079
name: positive regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "activation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related host MAPK-mediated signal transduction pathway" EXACT []
synonym: "positive regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway" EXACT []
synonym: "stimulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "up regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "up-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "upregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT []
is_a: GO:0052080 ! modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway
is_a: GO:0052276 ! positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:0075131 ! positive regulation by symbiont of host protein kinase-mediated signal transduction

[Term]
id: GO:0052080
name: modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of host MAP kinase-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of defense-related host MAPK-mediated signal transduction pathway by organism" EXACT []
synonym: "modulation of defense-related host mitogen activated protein kinase-mediated signal transduction pathway by organism" EXACT []
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052277 ! modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction
is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction

[Term]
id: GO:0052081
name: modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of defense-related host SA-mediated signal transduction pathway by organism" EXACT []
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052445 ! modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052082
name: modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of host jasmonic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of defense-related host JA-mediated signal transduction pathway by organism" EXACT []
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052443 ! modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052083
name: negative regulation by symbiont of host cell-mediated immune response
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host cell-mediated immune response" EXACT []
synonym: "down-regulation by symbiont of host cell-mediated immune response" EXACT []
synonym: "downregulation by symbiont of host cell-mediated immune response" EXACT []
synonym: "inhibition by symbiont of host cell-mediated immune response" NARROW []
synonym: "negative regulation by organism of host cell-based immune response" EXACT []
is_a: GO:0052155 ! modulation by symbiont of host cell-mediated immune response
is_a: GO:0052278 ! negative regulation by organism of cell-mediated immune response of other organism during symbiotic interaction
is_a: GO:0052562 ! negative regulation by symbiont of host immune response

[Term]
id: GO:0052084
name: modulation by symbiont of host ethylene-mediated defense response
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052279 ! modulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction

[Term]
id: GO:0052085
name: negative regulation by symbiont of host T-cell mediated immune response
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host T-cell mediated immune response" EXACT []
synonym: "down-regulation by symbiont of host T-cell mediated immune response" EXACT []
synonym: "downregulation by symbiont of host T-cell mediated immune response" EXACT []
synonym: "inhibition by symbiont of host T-cell mediated immune response" NARROW []
is_a: GO:0052083 ! negative regulation by symbiont of host cell-mediated immune response
is_a: GO:0052156 ! modulation by symbiont of host T-cell mediated immune response
is_a: GO:0052280 ! negative regulation by organism of T-cell mediated immune response of other organism during symbiotic interaction

[Term]
id: GO:0052086
name: negative regulation by symbiont of host B-cell mediated immune response
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host B-cell mediated immune response" EXACT []
synonym: "down-regulation by symbiont of host B-cell mediated immune response" EXACT []
synonym: "downregulation by symbiont of host B-cell mediated immune response" EXACT []
synonym: "inhibition by symbiont of host B-cell mediated immune response" NARROW []
is_a: GO:0052154 ! modulation by symbiont of host B-cell mediated immune response
is_a: GO:0052281 ! negative regulation by organism of B-cell mediated immune response of other organism during symbiotic interaction
is_a: GO:0052562 ! negative regulation by symbiont of host immune response

[Term]
id: GO:0052087
name: negative regulation by symbiont of defense-related host callose deposition
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of callose deposition performed by the host as part of its defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of defense-related host callose deposition" EXACT []
synonym: "down-regulation by symbiont of defense-related host callose deposition" EXACT []
synonym: "downregulation by symbiont of defense-related host callose deposition" EXACT []
synonym: "inhibition by symbiont of defense-related host callose deposition" NARROW []
synonym: "suppression by organism of defense-related host callose deposition" EXACT []
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052090 ! modulation by symbiont of defense-related host callose deposition
is_a: GO:0052282 ! negative regulation by organism of defense-related callose deposition in other organism during symbiotic interaction

[Term]
id: GO:0052088
name: modulation by symbiont of host jasmonic acid-mediated defense response
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of host JA-mediated defense response" EXACT []
is_a: GO:0052283 ! modulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response

[Term]
id: GO:0052089
name: modulation by symbiont of host salicylic acid-mediated defense response
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of host SA-mediated defense response" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0010112 ! regulation of systemic acquired resistance
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052284 ! modulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction
relationship: regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway

[Term]
id: GO:0052090
name: modulation by symbiont of defense-related host callose deposition
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of callose deposition by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052285 ! modulation by organism of defense-related callose deposition of other organism during symbiotic interaction

[Term]
id: GO:0052091
name: modulation by symbiont of nutrient release from host
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0052313 ! modulation of nutrient release from other organism during symbiotic interaction
relationship: part_of GO:0044002 ! acquisition of nutrients from host

[Term]
id: GO:0052092
name: positive regulation by symbiont of nutrient release from host
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of nutrient release from host" NARROW []
synonym: "promotion of nutrient release from host" EXACT []
synonym: "stimulation by symbiont of nutrient release from host" NARROW []
synonym: "up regulation by symbiont of nutrient release from host" EXACT []
synonym: "up-regulation by symbiont of nutrient release from host" EXACT []
synonym: "upregulation by symbiont of nutrient release from host" EXACT []
is_a: GO:0052091 ! modulation by symbiont of nutrient release from host
is_a: GO:0052520 ! positive regulation by organism of nutrient release from other organism during symbiotic interaction

[Term]
id: GO:0052093
name: formation of specialized structure for nutrient acquisition from host
namespace: biological_process
def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "formation by organism of specialized structure for nutrient acquisition from host" EXACT []
synonym: "formation by symbiont of specialized structure for nutrient acquisition from host" EXACT []
is_a: GO:0044115 ! development of symbiont during interaction with host
is_a: GO:0052095 ! formation of specialized structure for nutrient acquisition from other organism during symbiotic interaction
relationship: part_of GO:0044002 ! acquisition of nutrients from host

[Term]
id: GO:0052094
name: formation by symbiont of haustorium for nutrient acquisition from host
namespace: biological_process
def: "The assembly by an organism of a haustorium, a projection from a cell or tissue that penetrates the host's tissues for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.onelook.com]
synonym: "formation by organism of haustoria for nutrient acquisition from host" EXACT []
synonym: "formation by organism of haustorium for nutrient acquisition from host" EXACT []
is_a: GO:0044118 ! development of symbiont in host cell
is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host

[Term]
id: GO:0052095
name: formation of specialized structure for nutrient acquisition from other organism during symbiotic interaction
namespace: biological_process
def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0044111 ! development during symbiotic interaction
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction

[Term]
id: GO:0052096
name: formation by symbiont of syncytium involving giant cell for nutrient acquisition from host
namespace: biological_process
def: "The assembly by an organism of a syncytium, a nematode-induced multi-nucleate and physiologically active aggregation of fused root cells which exclusively provides the nematode with nourishment during its sedentary life, for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "formation by organism of syncytium involving giant cell for nutrient acquisition from host" EXACT []
is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host

[Term]
id: GO:0052097
name: interspecies quorum sensing
namespace: biological_process
def: "The process in which a community of single-celled organisms of different species monitors population density by detecting the concentration of small diffusible signal molecules." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0009372 ! quorum sensing
is_a: GO:0044419 ! interspecies interaction between organisms

[Term]
id: GO:0052098
name: formation by host of specialized structure for nutrient acquisition from symbiont
namespace: biological_process
def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051850 ! acquisition of nutrients from symbiont
is_a: GO:0052095 ! formation of specialized structure for nutrient acquisition from other organism during symbiotic interaction

[Term]
id: GO:0052099
name: acquisition by symbiont of nutrients from host via siderophores
namespace: biological_process
synonym: "acquisition by organism of nutrients from host via siderophores" EXACT []
is_a: GO:0044002 ! acquisition of nutrients from host

[Term]
id: GO:0052100
name: intraspecies quorum sensing
namespace: biological_process
def: "The process in which single-celled organisms of the same species monitor population density by detecting the concentration of small, diffusible signal molecules." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0009372 ! quorum sensing
is_a: GO:0051703 ! intraspecies interaction between organisms

[Term]
id: GO:0052101
name: induction by symbiont of host resistance gene-dependent defense response
namespace: biological_process
def: "The activation by an organism of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense response in host by specific elicitors" EXACT []
synonym: "activation by organism of host gene-for-gene resistance" EXACT []
synonym: "activation by organism of host resistance gene-dependent defense response" EXACT []
synonym: "activation by organism of pathogen-race/host plant cultivar-specific resistance in host" EXACT []
synonym: "induction by organism of defense response in host by specific elicitors" EXACT []
synonym: "induction by organism of host gene-for-gene resistance" EXACT []
synonym: "induction by organism of pathogen-race/host plant cultivar-specific resistance in host" EXACT []
is_a: GO:0052286 ! induction by organism of resistance gene-dependent defense response of other organism during symbiotic interaction
is_a: GO:0052527 ! positive regulation by symbiont of host resistance gene-dependent defense response
is_a: GO:0052559 ! induction by symbiont of host immune response

[Term]
id: GO:0052102
name: positive regulation by symbiont of defense-related host calcium-dependent protein kinase pathway
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the host calcium-dependent protein kinase pathway during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of defense-related host calcium-dependent protein kinase pathway" NARROW []
synonym: "positive regulation of defense-related host CDPK pathway by organism" EXACT []
synonym: "stimulation by symbiont of defense-related host calcium-dependent protein kinase pathway" NARROW []
synonym: "up regulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT []
synonym: "up-regulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT []
synonym: "upregulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT []
is_a: GO:0052168 ! modulation by symbiont of defense-related host calcium-dependent protein kinase pathway
is_a: GO:0052287 ! positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response

[Term]
id: GO:0052103
name: induction by symbiont of host induced systemic resistance
namespace: biological_process
def: "Any process by which an organism activates induced systemic resistance in the host; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of induced systemic resistance in host" EXACT []
synonym: "activation by organism of ISR in host" EXACT []
synonym: "induction by organism of ISR in host" EXACT []
synonym: "induction by symbiont of induced systemic resistance in host" EXACT []
is_a: GO:0052288 ! induction by organism of induced systemic resistance in other organism during symbiotic interaction
is_a: GO:0052390 ! induction by symbiont of host innate immunity
is_a: GO:0052533 ! positive regulation by symbiont of host induced systemic resistance

[Term]
id: GO:0052104
name: induction by symbiont of host systemic acquired resistance
namespace: biological_process
def: "Any process by which an organism activates systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of SAR in host" EXACT []
synonym: "activation by organism of systemic acquired resistance in host" EXACT []
synonym: "induction by organism of SAR in host" EXACT []
synonym: "induction by symbiont of systemic acquired resistance in host" EXACT []
is_a: GO:0052289 ! induction by organism of systemic acquired resistance in other organism during symbiotic interaction
is_a: GO:0052390 ! induction by symbiont of host innate immunity
is_a: GO:0052537 ! positive regulation by symbiont of host systemic acquired resistance

[Term]
id: GO:0052105
name: induction by symbiont of defense-related host cell wall thickening
namespace: biological_process
def: "The activation by an organism of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related host cell wall thickening" EXACT []
synonym: "activation by organism of host defensive cell wall thickening" EXACT []
synonym: "induction by organism of host defensive cell wall thickening" EXACT []
is_a: GO:0044416 ! induction by symbiont of host defense response
is_a: GO:0052290 ! induction by organism of defense-related cell wall thickening in other organism during symbiotic interaction
is_a: GO:0052539 ! positive regulation by symbiont of defense-related host cell wall thickening

[Term]
id: GO:0052106
name: quorum sensing during interaction with host
namespace: biological_process
def: "The process in which a community of single-celled organisms living in intimate contact with a host organism monitors population density by detecting the concentration of small diffusible signal molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052097 ! interspecies quorum sensing
relationship: part_of GO:0051701 ! interaction with host

[Term]
id: GO:0052107
name: positive regulation by symbiont of defense-related host callose deposition
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of callose deposition by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of defense-related host callose deposition" NARROW []
synonym: "induction by organism of defense-related host callose deposition" NARROW []
synonym: "induction by organism of defense-related papilla formation in host" NARROW []
synonym: "positive regulation by organism of defense-related papilla formation in host" EXACT []
synonym: "stimulation by symbiont of defense-related host callose deposition" NARROW []
synonym: "up regulation by symbiont of defense-related host callose deposition" EXACT []
synonym: "up-regulation by symbiont of defense-related host callose deposition" EXACT []
synonym: "upregulation by symbiont of defense-related host callose deposition" EXACT []
is_a: GO:0052090 ! modulation by symbiont of defense-related host callose deposition
is_a: GO:0052291 ! positive regulation by organism of defense-related callose deposition in other organism during symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response

[Term]
id: GO:0052108
name: growth or development of symbiont during interaction with host
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of symbiont during interaction with host ; GO:0044116' and 'development of symbiont during interaction with host ; GO:0044115'.
subset: gosubset_prok
synonym: "growth or development of organism during interaction with host" EXACT []
synonym: "growth or development of organism in response to host" EXACT []
is_obsolete: true
replaced_by: GO:0044115
replaced_by: GO:0044116

[Term]
id: GO:0052109
name: positive regulation by symbiont of defense-related host cell wall callose deposition
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of defense-related host cell wall callose deposition" NARROW []
synonym: "induction by organism of defense-related host cell wall callose deposition" NARROW []
synonym: "positive regulation by organism of defense-related host cell wall callose deposition" EXACT []
synonym: "stimulation by symbiont of defense-related host cell wall callose deposition" NARROW []
synonym: "up regulation by symbiont of defense-related host cell wall callose deposition" EXACT []
synonym: "up-regulation by symbiont of defense-related host cell wall callose deposition" EXACT []
synonym: "upregulation by symbiont of defense-related host cell wall callose deposition" EXACT []
is_a: GO:0052107 ! positive regulation by symbiont of defense-related host callose deposition
is_a: GO:0052189 ! modulation by symbiont of defense-related host cell wall callose deposition
is_a: GO:0052292 ! positive regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction
is_a: GO:0052539 ! positive regulation by symbiont of defense-related host cell wall thickening

[Term]
id: GO:0052110
name: occlusion by symbiont of host vascular system
namespace: biological_process
def: "The process by which an organism reduces the flow of fluid within its host's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com]
subset: gosubset_prok
is_a: GO:0052111 ! modification by symbiont of host structure
is_a: GO:0052495 ! occlusion by organism of vascular system in other organism during symbiotic interaction

[Term]
id: GO:0052111
name: modification by symbiont of host structure
namespace: biological_process
def: "The process by which an organism effects a change in an anatomical part or cellular component of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044003 ! modification by symbiont of host morphology or physiology
is_a: GO:0052185 ! modification of structure of other organism during symbiotic interaction

[Term]
id: GO:0052112
name: occlusion by symbiont of host xylem
namespace: biological_process
def: "The process by which an organism reduces the flow of fluid within the host xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052110 ! occlusion by symbiont of host vascular system
is_a: GO:0052497 ! occlusion by organism of xylem in other organism during symbiotic interaction

[Term]
id: GO:0052113
name: adaptation to host osmotic environment
namespace: biological_process
def: "OBSOLETE. The responsive adjustment of an organism to the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was made obsolete because adaptation was not deemed to be a valid biological process.
subset: gosubset_prok
synonym: "osmotic tolerance to host environment" EXACT []
is_obsolete: true

[Term]
id: GO:0052114
name: adaptation to host pH environment
namespace: biological_process
def: "OBSOLETE. The responsive adjustment of an organism to the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was made obsolete because adaptation was not deemed to be a valid biological process.
subset: gosubset_prok
synonym: "pH tolerance to host environment" EXACT []
is_obsolete: true

[Term]
id: GO:0052115
name: energy taxis in host environment
namespace: biological_process
def: "The directed movement of a motile cell or organism in the environment of its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "energy taxis in response to host environment" EXACT []
is_a: GO:0052126 ! movement in host environment
is_a: GO:0052215 ! energy taxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052116
name: chemotaxis in host environment
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "chemotaxis in response to host environment" EXACT []
is_a: GO:0052126 ! movement in host environment
is_a: GO:0052216 ! chemotaxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052117
name: aerotaxis in host environment
namespace: biological_process
def: "The movement of a motile cell or organism in response to environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "aerotaxis in response to host environment" EXACT []
is_a: GO:0052115 ! energy taxis in host environment
is_a: GO:0052116 ! chemotaxis in host environment
is_a: GO:0052217 ! aerotaxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052118
name: positive energy taxis in host environment
namespace: biological_process
def: "The directed movement of a motile cell or organism on, within or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive energy taxis in response to host environment" EXACT []
is_a: GO:0052115 ! energy taxis in host environment
is_a: GO:0052218 ! positive energy taxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052119
name: negative energy taxis in host environment
namespace: biological_process
def: "The directed movement of a motile cell or organism on, within or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative energy taxis in response to host environment" EXACT []
is_a: GO:0052115 ! energy taxis in host environment
is_a: GO:0052219 ! negative energy taxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052120
name: positive aerotaxis in host environment
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive aerotaxis in response to host environment" EXACT []
is_a: GO:0052117 ! aerotaxis in host environment
is_a: GO:0052118 ! positive energy taxis in host environment
is_a: GO:0052121 ! positive chemotaxis in host environment
is_a: GO:0052220 ! positive aerotaxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052121
name: positive chemotaxis in host environment
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive chemotaxis in response to host environment" EXACT []
is_a: GO:0052116 ! chemotaxis in host environment
is_a: GO:0052221 ! positive chemotaxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052122
name: negative aerotaxis in host environment
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative aerotaxis in response to host environment" EXACT []
is_a: GO:0052117 ! aerotaxis in host environment
is_a: GO:0052119 ! negative energy taxis in host environment
is_a: GO:0052123 ! negative chemotaxis in host environment
is_a: GO:0052222 ! negative aerotaxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052123
name: negative chemotaxis in host environment
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative chemotaxis in response to host environment" EXACT []
is_a: GO:0052116 ! chemotaxis in host environment
is_a: GO:0052223 ! negative chemotaxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052124
name: energy taxis within host
namespace: biological_process
def: "The directed movement of a motile cell or organism within its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044000 ! movement in host
is_a: GO:0052115 ! energy taxis in host environment
is_a: GO:0052224 ! energy taxis in other organism during symbiotic interaction

[Term]
id: GO:0052125
name: energy taxis on or near host
namespace: biological_process
def: "The directed movement of a motile cell or organism on or near its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052115 ! energy taxis in host environment
is_a: GO:0052127 ! movement on or near host
is_a: GO:0052225 ! energy taxis on or near other organism during symbiotic interaction

[Term]
id: GO:0052126
name: movement in host environment
namespace: biological_process
def: "The directed movement of an organism or motile cell on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "movement in response to host" EXACT []
is_a: GO:0051701 ! interaction with host
is_a: GO:0052192 ! movement in environment of other organism during symbiotic interaction

[Term]
id: GO:0052127
name: movement on or near host
namespace: biological_process
def: "The directed movement of an organism or motile cell on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052126 ! movement in host environment
is_a: GO:0052195 ! movement on or near other organism during symbiotic interaction

[Term]
id: GO:0052128
name: positive energy taxis
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:mtg_pamgo_17jul06]
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0052129
name: negative energy taxis
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:mtg_pamgo_17jul06]
is_a: GO:0009453 ! energy taxis

[Term]
id: GO:0052130
name: negative aerotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen." [GOC:dph, GOC:mtg_pamgo_17jul06]
is_a: GO:0009454 ! aerotaxis
is_a: GO:0050919 ! negative chemotaxis
is_a: GO:0052129 ! negative energy taxis

[Term]
id: GO:0052131
name: positive aerotaxis
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen." [GOC:dph, GOC:mtg_pamgo_17jul06]
is_a: GO:0009454 ! aerotaxis
is_a: GO:0050918 ! positive chemotaxis
is_a: GO:0052128 ! positive energy taxis

[Term]
id: GO:0052132
name: positive aerotaxis on or near host
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052120 ! positive aerotaxis in host environment
is_a: GO:0052138 ! aerotaxis on or near host
is_a: GO:0052141 ! positive chemotaxis on or near host
is_a: GO:0052146 ! positive energy taxis on or near host
is_a: GO:0052232 ! positive aerotaxis on or near other organism during symbiotic interaction

[Term]
id: GO:0052133
name: positive aerotaxis in host
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive aerotaxis within host" EXACT []
is_a: GO:0052120 ! positive aerotaxis in host environment
is_a: GO:0052137 ! aerotaxis in host
is_a: GO:0052140 ! positive chemotaxis in host
is_a: GO:0052147 ! positive energy taxis in host
is_a: GO:0052233 ! positive aerotaxis in other organism during symbiotic interaction

[Term]
id: GO:0052134
name: negative aerotaxis on or near host
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052122 ! negative aerotaxis in host environment
is_a: GO:0052136 ! negative chemotaxis on or near host
is_a: GO:0052138 ! aerotaxis on or near host
is_a: GO:0052145 ! negative energy taxis on or near host
is_a: GO:0052234 ! negative aerotaxis on or near other organism during symbiotic interaction

[Term]
id: GO:0052135
name: negative aerotaxis in host
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative aerotaxis within host" EXACT []
is_a: GO:0052122 ! negative aerotaxis in host environment
is_a: GO:0052137 ! aerotaxis in host
is_a: GO:0052139 ! negative chemotaxis in host
is_a: GO:0052144 ! negative energy taxis in host
is_a: GO:0052235 ! negative aerotaxis in other organism during symbiotic interaction

[Term]
id: GO:0052136
name: negative chemotaxis on or near host
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052123 ! negative chemotaxis in host environment
is_a: GO:0052143 ! chemotaxis on or near host during symbiotic interaction
is_a: GO:0052236 ! negative chemotaxis on or near other organism during symbiotic interaction

[Term]
id: GO:0052137
name: aerotaxis in host
namespace: biological_process
def: "The movement of a motile cell or organism in response to environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "aerotaxis within host" EXACT []
is_a: GO:0052117 ! aerotaxis in host environment
is_a: GO:0052124 ! energy taxis within host
is_a: GO:0052142 ! chemotaxis within host
is_a: GO:0052237 ! aerotaxis in other organism during symbiotic interaction

[Term]
id: GO:0052138
name: aerotaxis on or near host
namespace: biological_process
def: "The movement of a motile cell or organism in response to environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052117 ! aerotaxis in host environment
is_a: GO:0052125 ! energy taxis on or near host
is_a: GO:0052143 ! chemotaxis on or near host during symbiotic interaction
is_a: GO:0052238 ! aerotaxis on or near other organism during symbiotic interaction

[Term]
id: GO:0052139
name: negative chemotaxis in host
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative chemotaxis within host" EXACT []
is_a: GO:0052123 ! negative chemotaxis in host environment
is_a: GO:0052142 ! chemotaxis within host
is_a: GO:0052239 ! negative chemotaxis in other organism during symbiotic interaction

[Term]
id: GO:0052140
name: positive chemotaxis in host
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive chemotaxis within host" EXACT []
is_a: GO:0052121 ! positive chemotaxis in host environment
is_a: GO:0052142 ! chemotaxis within host
is_a: GO:0052240 ! positive chemotaxis in other organism during symbiotic interaction

[Term]
id: GO:0052141
name: positive chemotaxis on or near host
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052121 ! positive chemotaxis in host environment
is_a: GO:0052143 ! chemotaxis on or near host during symbiotic interaction
is_a: GO:0052241 ! positive chemotaxis on or near other organism during symbiotic interaction

[Term]
id: GO:0052142
name: chemotaxis within host
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044000 ! movement in host
is_a: GO:0052116 ! chemotaxis in host environment
is_a: GO:0052242 ! chemotaxis in other organism during symbiotic interaction

[Term]
id: GO:0052143
name: chemotaxis on or near host during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052116 ! chemotaxis in host environment
is_a: GO:0052127 ! movement on or near host
is_a: GO:0052243 ! chemotaxis on or near other organism during symbiotic interaction

[Term]
id: GO:0052144
name: negative energy taxis in host
namespace: biological_process
def: "The directed movement of a motile cell or organism within its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative energy taxis within host" EXACT []
is_a: GO:0052119 ! negative energy taxis in host environment
is_a: GO:0052124 ! energy taxis within host
is_a: GO:0052244 ! negative energy taxis in other organism during symbiotic interaction

[Term]
id: GO:0052145
name: negative energy taxis on or near host
namespace: biological_process
def: "The directed movement of a motile cell or organism on or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052119 ! negative energy taxis in host environment
is_a: GO:0052125 ! energy taxis on or near host
is_a: GO:0052245 ! negative energy taxis on or near other organism during symbiotic interaction

[Term]
id: GO:0052146
name: positive energy taxis on or near host
namespace: biological_process
def: "The directed movement of a motile cell or organism on or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052118 ! positive energy taxis in host environment
is_a: GO:0052125 ! energy taxis on or near host
is_a: GO:0052246 ! positive energy taxis on or near other organism during symbiotic interaction

[Term]
id: GO:0052147
name: positive energy taxis in host
namespace: biological_process
def: "The directed movement of a motile cell or organism within its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive energy taxis within host" EXACT []
is_a: GO:0052118 ! positive energy taxis in host environment
is_a: GO:0052124 ! energy taxis within host
is_a: GO:0052247 ! positive energy taxis in other organism during symbiotic interaction

[Term]
id: GO:0052148
name: modulation by symbiont of host catalytic activity
namespace: biological_process
def: "The process by which an organism effects a change in host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "modulation by symbiont of host enzyme activity" EXACT [GOC:tb]
synonym: "modulation of catalytic activity of host by symbiont" EXACT []
synonym: "regulation by symbiont of host catalytic activity" EXACT []
synonym: "regulation of catalytic activity of host by symbiont" EXACT []
synonym: "regulation of host catalytic activity by symbiont" EXACT []
is_a: GO:0052055 ! modulation by symbiont of host molecular function
is_a: GO:0052203 ! modulation of catalytic activity in other organism during symbiotic interaction

[Term]
id: GO:0052149
name: modulation by symbiont of host protease activity
namespace: biological_process
def: "The process by which an organism effects a change in host protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052148 ! modulation by symbiont of host catalytic activity
is_a: GO:0052198 ! modulation of protease activity in other organism during symbiotic interaction

[Term]
id: GO:0052150
name: modulation by symbiont of host apoptosis
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'regulation of apoptosis ; GO:0042981'.
subset: gosubset_prok
synonym: "modulation by organism of host apoptotic programmed cell death" EXACT []
is_a: GO:0052040 ! modulation by symbiont of host programmed cell death
is_a: GO:0052433 ! modulation by organism of apoptosis in other organism during symbiotic interaction

[Term]
id: GO:0052151
name: positive regulation by symbiont of host apoptosis
namespace: biological_process
alt_id: GO:0033669
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'positive regulation of apoptosis ; GO:0043065'.
subset: gosubset_prok
synonym: "activation by symbiont of host apoptosis" NARROW []
synonym: "positive regulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "stimulation by symbiont of host apoptosis" NARROW []
synonym: "up regulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "up regulation by symbiont of host apoptosis" EXACT []
synonym: "up-regulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "up-regulation by symbiont of host apoptosis" EXACT []
synonym: "upregulation by organism of host apoptotic programmed cell death" EXACT []
synonym: "upregulation by symbiont of host apoptosis" EXACT []
is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death
is_a: GO:0052150 ! modulation by symbiont of host apoptosis
is_a: GO:0052501 ! positive regulation by organism of apoptosis in other organism during symbiotic interaction

[Term]
id: GO:0052154
name: modulation by symbiont of host B-cell mediated immune response
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "regulation by organism of host B-cell mediated immune response" EXACT []
is_a: GO:0052293 ! modulation by organism of B-cell mediated immune response of other organism during symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response

[Term]
id: GO:0052155
name: modulation by symbiont of host cell-mediated immune response
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of any form of cell-based immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of host cell-based immune response" EXACT []
is_a: GO:0052294 ! modulation by organism of cell-mediated immune response of other organism during symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response

[Term]
id: GO:0052156
name: modulation by symbiont of host T-cell mediated immune response
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052155 ! modulation by symbiont of host cell-mediated immune response
is_a: GO:0052295 ! modulation by organism of T-cell mediated immune response of other organism during symbiotic interaction

[Term]
id: GO:0052157
name: modulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity
namespace: biological_process
subset: gosubset_prok
is_a: GO:0052167 ! modulation by symbiont of host innate immunity
is_a: GO:0052296 ! modulation by organism of pathogen-associated molecular pattern-induced innate immunity in other organism during symbiotic interaction

[Term]
id: GO:0052158
name: modulation by symbiont of host resistance gene-dependent defense response
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense response in host by specific elicitors" EXACT []
synonym: "modulation by organism of host gene-for-gene resistance" EXACT []
synonym: "modulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT []
is_a: GO:0052297 ! modulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response

[Term]
id: GO:0052159
name: modulation by symbiont of host induced systemic resistance
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by symbiont of induced systemic resistance in host" EXACT []
is_a: GO:0052298 ! modulation by organism of induced systemic resistance in other organism during symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response

[Term]
id: GO:0052160
name: modulation by symbiont of host systemic acquired resistance
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by symbiont of systemic acquired resistance in host" EXACT []
is_a: GO:0052299 ! modulation by organism of systemic acquired resistance in other organism during symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response

[Term]
id: GO:0052161
name: modulation by symbiont of defense-related host cell wall thickening
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of host defensive cell wall thickening" RELATED []
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052300 ! modulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction

[Term]
id: GO:0052162
name: modulation by symbiont of defense-related host calcium ion flux
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related host Ca2+ flux" EXACT []
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052301 ! modulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction

[Term]
id: GO:0052163
name: modulation by symbiont of defense-related host nitric oxide production
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related host NO production" EXACT []
is_a: GO:0052302 ! modulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response
is_a: GO:0052565 ! response to defense-related host nitric oxide production

[Term]
id: GO:0052164
name: modulation by symbiont of defense-related host reactive oxygen species production
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related host active oxygen species production" EXACT []
synonym: "modulation by organism of defense-related host AOS production" EXACT []
synonym: "modulation by organism of defense-related host metabolic burst" EXACT []
synonym: "modulation by organism of defense-related host oxidative burst" EXACT []
synonym: "modulation by organism of defense-related host reactive oxidative species production" EXACT []
synonym: "modulation by organism of defense-related host reactive oxygen intermediate production" EXACT []
synonym: "modulation by organism of defense-related host respiratory burst" EXACT []
synonym: "modulation by organism of defense-related host ROI production" EXACT []
synonym: "modulation by organism of defense-related host ROS production" EXACT []
is_a: GO:0052303 ! modulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response
is_a: GO:0052567 ! response to defense-related host reactive oxygen species production

[Term]
id: GO:0052165
name: modulation by symbiont of host phytoalexin production
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052304 ! modulation by organism of phytoalexin production in other organism during symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response
is_a: GO:0052566 ! response to host phytoalexin production

[Term]
id: GO:0052166
name: positive regulation by symbiont of host innate immunity
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host innate immunity" NARROW []
synonym: "induction of host innate immune response" NARROW []
synonym: "induction of host innate immunity" NARROW []
synonym: "positive regulation of host innate immune response" EXACT []
synonym: "stimulation by symbiont of host innate immunity" NARROW []
synonym: "up regulation by symbiont of host innate immunity" EXACT []
synonym: "up-regulation by symbiont of host innate immunity" EXACT []
synonym: "upregulation by symbiont of host innate immunity" EXACT []
is_a: GO:0052167 ! modulation by symbiont of host innate immunity
is_a: GO:0052305 ! positive regulation by organism of innate immunity in other organism during symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:0052556 ! positive regulation by symbiont of host immune response

[Term]
id: GO:0052167
name: modulation by symbiont of host innate immunity
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of host innate immune response" EXACT []
is_a: GO:0052306 ! modulation by organism of innate immunity in other organism during symbiotic interaction
is_a: GO:0052553 ! modulation by symbiont of host immune response

[Term]
id: GO:0052168
name: modulation by symbiont of defense-related host calcium-dependent protein kinase pathway
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the host calcium-dependent protein kinase signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related host CDPK pathway" EXACT []
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052307 ! modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction

[Term]
id: GO:0052169
name: pathogen-associated molecular pattern dependent modulation by symbiont of host innate immunity
namespace: biological_process
subset: gosubset_prok
is_a: GO:0052167 ! modulation by symbiont of host innate immunity
is_a: GO:0052308 ! pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism during symbiotic interaction

[Term]
id: GO:0052170
name: negative regulation by symbiont of host innate immunity
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host innate immunity" EXACT []
synonym: "down-regulation by symbiont of host innate immunity" EXACT []
synonym: "downregulation by symbiont of host innate immunity" EXACT []
synonym: "inhibition by symbiont of host innate immunity" NARROW []
synonym: "negative regulation of host innate immune response" EXACT []
is_a: GO:0052037 ! negative regulation by symbiont of host defense response
is_a: GO:0052167 ! modulation by symbiont of host innate immunity
is_a: GO:0052309 ! negative regulation by organism of innate immunity in other organism during symbiotic interaction
is_a: GO:0052562 ! negative regulation by symbiont of host immune response

[Term]
id: GO:0052171
name: growth or development during symbiotic interaction
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development during symbiotic interaction ; GO:0044111' and 'growth during symbiotic interaction ; GO:0044110'.
subset: gosubset_prok
is_obsolete: true
replaced_by: GO:0044110
replaced_by: GO:0044111

[Term]
id: GO:0052172
name: metabolism by symbiont of host cell wall cellulose
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate
is_a: GO:0052409 ! metabolism by organism of cell wall cellulose in other organism during symbiotic interaction

[Term]
id: GO:0052173
name: response to defenses of other organism during symbiotic interaction
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0051707 ! response to other organism
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0052174
name: metabolism by symbiont of host macromolecule
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052002 ! metabolism by symbiont of substance in host
is_a: GO:0052229 ! metabolism of macromolecule in other organism during symbiotic interaction

[Term]
id: GO:0052175
name: metabolism by symbiont of host carbohydrate
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving carbohydrates within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052174 ! metabolism by symbiont of host macromolecule
is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism during symbiotic interaction

[Term]
id: GO:0052176
name: metabolism by symbiont of host glucan
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving glucans within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate
is_a: GO:0052415 ! metabolism by organism of glucan in other organism during symbiotic interaction

[Term]
id: GO:0052177
name: metabolism by symbiont of host xylan
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate
is_a: GO:0052421 ! metabolism by organism of xylan in other organism during symbiotic interaction

[Term]
id: GO:0052178
name: metabolism by symbiont of host cell wall chitin
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate
is_a: GO:0052411 ! metabolism by organism of cell wall chitin in other organism during symbiotic interaction

[Term]
id: GO:0052179
name: metabolism by symbiont of host cell wall pectin
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052175 ! metabolism by symbiont of host carbohydrate
is_a: GO:0052413 ! metabolism by organism of cell wall pectin in other organism during symbiotic interaction

[Term]
id: GO:0052180
name: negative regulation of peptidase activity in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of protease activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of protease activity in other organism during symbiotic interaction" EXACT []
synonym: "down-regulation of protease activity in other organism during symbiotic interaction" EXACT []
synonym: "downregulation of protease activity in other organism during symbiotic interaction" EXACT []
synonym: "inhibition of protease activity in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation of protease activity in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010466 ! negative regulation of peptidase activity
is_a: GO:0052198 ! modulation of protease activity in other organism during symbiotic interaction
is_a: GO:0052199 ! negative regulation of catalytic activity in other organism during symbiotic interaction

[Term]
id: GO:0052181
name: modulation by host of symbiont defense response
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052201 ! response to symbiont defenses
is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052182
name: modification by host of symbiont morphology or physiology via secreted substance
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of a symbiont organism, mediated by a substance secreted by one of the organisms. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance during symbiotic interaction
is_a: GO:0052213 ! interaction with symbiont via secreted substance during symbiotic interaction

[Term]
id: GO:0052183
name: modification by host of symbiont structure
namespace: biological_process
def: "The process by which an organism effects a change in an anatomical part or cellular component of the host organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052185 ! modification of structure of other organism during symbiotic interaction

[Term]
id: GO:0052184
name: modulation by organism of symbiont hormone or growth regulator levels
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of hormones or growth regulators in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052185
name: modification of structure of other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism effects a change in an anatomical part or cellular component of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction

[Term]
id: GO:0052186
name: modulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction
namespace: biological_process
def: "The alteration by an organism of the levels of hormones or growth regulators in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction

[Term]
id: GO:0052187
name: modification by host of symbiont cellular component
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of a symbiont cellular component. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052183 ! modification by host of symbiont structure
is_a: GO:0052188 ! modification of cellular component in other organism during symbiotic interaction

[Term]
id: GO:0052188
name: modification of cellular component in other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of a cellular component in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052185 ! modification of structure of other organism during symbiotic interaction

[Term]
id: GO:0052189
name: modulation by symbiont of defense-related host cell wall callose deposition
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052090 ! modulation by symbiont of defense-related host callose deposition
is_a: GO:0052161 ! modulation by symbiont of defense-related host cell wall thickening
is_a: GO:0052310 ! modulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction

[Term]
id: GO:0052190
name: modulation by symbiont of host phagocytosis
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0044068 ! modulation by symbiont of host cellular process
is_a: GO:0052231 ! modulation of phagocytosis in other organism during symbiotic interaction

[Term]
id: GO:0052191
name: positive regulation by symbiont of host phagocytosis
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by symbiont of host phagocytosis" NARROW []
synonym: "stimulation by symbiont of host phagocytosis" NARROW []
synonym: "up regulation by symbiont of host phagocytosis" EXACT []
synonym: "up-regulation by symbiont of host phagocytosis" EXACT []
synonym: "upregulation by symbiont of host phagocytosis" EXACT []
is_a: GO:0052190 ! modulation by symbiont of host phagocytosis
is_a: GO:0052522 ! positive regulation by organism of phagocytosis in other organism during symbiotic interaction

[Term]
id: GO:0052192
name: movement in environment of other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of an organism or motile cell on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "locomotion in environment of other organism during symbiotic interaction" EXACT []
is_a: GO:0040011 ! locomotion
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0052193
name: movement in symbiont environment
namespace: biological_process
def: "The directed movement of an organism or motile cell on, within or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0051702 ! interaction with symbiont
is_a: GO:0052192 ! movement in environment of other organism during symbiotic interaction

[Term]
id: GO:0052194
name: movement on or near symbiont
namespace: biological_process
def: "The directed movement of an organism or motile cell on or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052193 ! movement in symbiont environment
is_a: GO:0052195 ! movement on or near other organism during symbiotic interaction

[Term]
id: GO:0052195
name: movement on or near other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of an organism or motile cell on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052192 ! movement in environment of other organism during symbiotic interaction

[Term]
id: GO:0052196
name: negative regulation by host of symbiont defense response
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by host of symbiont defense response" EXACT []
synonym: "down-regulation by host of symbiont defense response" EXACT []
synonym: "downregulation by host of symbiont defense response" EXACT []
synonym: "inhibition by host of symbiont defense response" NARROW []
is_a: GO:0051859 ! suppression of symbiont defenses
is_a: GO:0052181 ! modulation by host of symbiont defense response
is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052197
name: positive regulation by host of symbiont defense response
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by host of symbiont defense response" NARROW []
synonym: "stimulation by host of symbiont defense response" NARROW []
synonym: "up regulation by host of symbiont defense response" EXACT []
synonym: "up-regulation by host of symbiont defense response" EXACT []
synonym: "upregulation by host of symbiont defense response" EXACT []
is_a: GO:0052181 ! modulation by host of symbiont defense response
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052198
name: modulation of protease activity in other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism effects a change in protease activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052203 ! modulation of catalytic activity in other organism during symbiotic interaction

[Term]
id: GO:0052199
name: negative regulation of catalytic activity in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of enzyme activity in other organism during symbiotic interaction" EXACT []
synonym: "down-regulation of enzyme activity in other organism during symbiotic interaction" EXACT []
synonym: "downregulation of enzyme activity in other organism during symbiotic interaction" EXACT []
synonym: "inhibition of enzyme activity in other organism" EXACT []
synonym: "inhibition of enzyme activity in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation of enzyme activity in other organism during symbiotic interaction" EXACT [GOC:tb]
is_a: GO:0043086 ! negative regulation of catalytic activity
is_a: GO:0052203 ! modulation of catalytic activity in other organism during symbiotic interaction
is_a: GO:0052204 ! negative regulation of molecular function in other organism during symbiotic interaction

[Term]
id: GO:0052200
name: response to host defenses
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052173 ! response to defenses of other organism during symbiotic interaction
is_a: GO:0075136 ! response to host

[Term]
id: GO:0052201
name: response to symbiont defenses
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0009608 ! response to symbiont
is_a: GO:0052173 ! response to defenses of other organism during symbiotic interaction

[Term]
id: GO:0052202
name: negative regulation by symbiont of defense-related host cell wall callose deposition
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of defense-related host cell wall callose deposition" EXACT []
synonym: "down-regulation by symbiont of defense-related host cell wall callose deposition" EXACT []
synonym: "downregulation by symbiont of defense-related host cell wall callose deposition" EXACT []
synonym: "inhibition by symbiont of defense-related host cell wall callose deposition" NARROW []
is_a: GO:0052087 ! negative regulation by symbiont of defense-related host callose deposition
is_a: GO:0052189 ! modulation by symbiont of defense-related host cell wall callose deposition
is_a: GO:0052311 ! negative regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction

[Term]
id: GO:0052203
name: modulation of catalytic activity in other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism effects a change in enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "modulation of enzyme activity within other organism during symbiotic interaction" EXACT [GOC:tb]
is_a: GO:0050790 ! regulation of catalytic activity
is_a: GO:0052205 ! modulation of molecular function in other organism during symbiotic interaction

[Term]
id: GO:0052204
name: negative regulation of molecular function in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the functional activity of proteins in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "down regulation of protein function in other organism during symbiotic interaction" EXACT []
synonym: "down-regulation of protein function in other organism during symbiotic interaction" EXACT []
synonym: "downregulation of protein function in other organism during symbiotic interaction" EXACT []
synonym: "inhibition of protein function in other organism" EXACT []
synonym: "inhibition of protein function in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation of protein function in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0052205 ! modulation of molecular function in other organism during symbiotic interaction

[Term]
id: GO:0052205
name: modulation of molecular function in other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism effects a change in the function of proteins in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
subset: gosubset_prok
synonym: "modification of molecular function in other organism during symbiotic interaction" EXACT []
synonym: "modification of protein function in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb]
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0052206
name: modification of morphology or physiology of other organism via protein secreted by type II secretion system during symbiotic interaction
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type II secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052211 ! interaction with other organism via protein secreted by type II secretion system during symbiotic interaction
is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance during symbiotic interaction

[Term]
id: GO:0052207
name: modification of morphology or physiology of other organism via protein secreted by type III secretion system during symbiotic interaction
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type III secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052210 ! interaction with other organism via protein secreted by type III secretion system during symbiotic interaction
is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance during symbiotic interaction

[Term]
id: GO:0052208
name: modification of morphology or physiology of other organism via substance secreted by type IV secretion system during symbiotic interaction
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type IV secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052209 ! interaction with other organism via substance secreted by type IV secretion system during symbiotic interaction
is_a: GO:0052212 ! modification of morphology or physiology of other organism via secreted substance during symbiotic interaction

[Term]
id: GO:0052209
name: interaction with other organism via substance secreted by type IV secretion system during symbiotic interaction
namespace: biological_process
def: "An interaction with a second organism mediated by a substance secreted by the first organism by a type IV secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052047 ! interaction with other organism via secreted substance during symbiotic interaction

[Term]
id: GO:0052210
name: interaction with other organism via protein secreted by type III secretion system during symbiotic interaction
namespace: biological_process
def: "An interaction with a second organism mediated by a substance secreted by the first organism by a type III secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052047 ! interaction with other organism via secreted substance during symbiotic interaction

[Term]
id: GO:0052211
name: interaction with other organism via protein secreted by type II secretion system during symbiotic interaction
namespace: biological_process
def: "An interaction with a second organism mediated by a substance secreted by the first organism by a type II secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052047 ! interaction with other organism via secreted substance during symbiotic interaction

[Term]
id: GO:0052212
name: modification of morphology or physiology of other organism via secreted substance during symbiotic interaction
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by one of the organisms, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modification of host morphology or physiology via effector molecule" NARROW []
synonym: "modification of host morphology or physiology via ellicitor" NARROW []
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction
is_a: GO:0052047 ! interaction with other organism via secreted substance during symbiotic interaction

[Term]
id: GO:0052213
name: interaction with symbiont via secreted substance during symbiotic interaction
namespace: biological_process
def: "An interaction with the symbiont organism mediated by a substance secreted by the other (host) organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051702 ! interaction with symbiont
is_a: GO:0052047 ! interaction with other organism via secreted substance during symbiotic interaction

[Term]
id: GO:0052214
name: metabolism of substance in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0044033 ! multi-organism metabolic process
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction

[Term]
id: GO:0052215
name: energy taxis in environment of other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism in the environment of a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "energy taxis in response to environment of other organism" EXACT []
is_a: GO:0009453 ! energy taxis
is_a: GO:0052192 ! movement in environment of other organism during symbiotic interaction

[Term]
id: GO:0052216
name: chemotaxis in environment of other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "chemotaxis in response to environment of other organism" EXACT []
is_a: GO:0006935 ! chemotaxis
is_a: GO:0052192 ! movement in environment of other organism during symbiotic interaction

[Term]
id: GO:0052217
name: aerotaxis in environment of other organism during symbiotic interaction
namespace: biological_process
def: "The movement of a motile cell or organism in response to environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "aerotaxis in response to environment of other organism" EXACT []
is_a: GO:0009454 ! aerotaxis
is_a: GO:0052215 ! energy taxis in environment of other organism during symbiotic interaction
is_a: GO:0052216 ! chemotaxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052218
name: positive energy taxis in environment of other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism on, within or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive energy taxis in response to environment of other organism" EXACT []
is_a: GO:0052128 ! positive energy taxis
is_a: GO:0052215 ! energy taxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052219
name: negative energy taxis in environment of other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism on, within or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative energy taxis in response to environment of other organism" EXACT []
is_a: GO:0052129 ! negative energy taxis
is_a: GO:0052215 ! energy taxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052220
name: positive aerotaxis in environment of other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive aerotaxis in response to environment of other organism" EXACT []
is_a: GO:0052131 ! positive aerotaxis
is_a: GO:0052217 ! aerotaxis in environment of other organism during symbiotic interaction
is_a: GO:0052218 ! positive energy taxis in environment of other organism during symbiotic interaction
is_a: GO:0052221 ! positive chemotaxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052221
name: positive chemotaxis in environment of other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive chemotaxis in response to environment of other organism" EXACT []
is_a: GO:0050918 ! positive chemotaxis
is_a: GO:0052216 ! chemotaxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052222
name: negative aerotaxis in environment of other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative aerotaxis in response to environment of other organism" EXACT []
is_a: GO:0052130 ! negative aerotaxis
is_a: GO:0052217 ! aerotaxis in environment of other organism during symbiotic interaction
is_a: GO:0052219 ! negative energy taxis in environment of other organism during symbiotic interaction
is_a: GO:0052223 ! negative chemotaxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052223
name: negative chemotaxis in environment of other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative chemotaxis in response to environment of other organism" EXACT []
is_a: GO:0050919 ! negative chemotaxis
is_a: GO:0052216 ! chemotaxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052224
name: energy taxis in other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism within a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "energy taxis within other organism during symbiotic interaction" EXACT []
is_a: GO:0051814 ! movement in other organism during symbiotic interaction
is_a: GO:0052215 ! energy taxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052225
name: energy taxis on or near other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism on or near a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052195 ! movement on or near other organism during symbiotic interaction
is_a: GO:0052215 ! energy taxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052226
name: biosynthesis of substance in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in a second organism resulting in the formation of substances, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0044034 ! multi-organism biosynthetic process
is_a: GO:0052214 ! metabolism of substance in other organism during symbiotic interaction

[Term]
id: GO:0052227
name: catabolism of substance in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in a second organism resulting in the breakdown of substances, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0044035 ! multi-organism catabolic process
is_a: GO:0052214 ! metabolism of substance in other organism during symbiotic interaction

[Term]
id: GO:0052228
name: metabolism by symbiont of host protein
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052174 ! metabolism by symbiont of host macromolecule
is_a: GO:0052418 ! metabolism by organism of protein in other organism during symbiotic interaction

[Term]
id: GO:0052229
name: metabolism of macromolecule in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0043170 ! macromolecule metabolic process
is_a: GO:0052214 ! metabolism of substance in other organism during symbiotic interaction

[Term]
id: GO:0052230
name: modulation of intracellular transport in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of intracellular trafficking in other organism" EXACT []
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction

[Term]
id: GO:0052231
name: modulation of phagocytosis in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0050764 ! regulation of phagocytosis
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction

[Term]
id: GO:0052232
name: positive aerotaxis on or near other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052220 ! positive aerotaxis in environment of other organism during symbiotic interaction
is_a: GO:0052238 ! aerotaxis on or near other organism during symbiotic interaction
is_a: GO:0052241 ! positive chemotaxis on or near other organism during symbiotic interaction
is_a: GO:0052246 ! positive energy taxis on or near other organism during symbiotic interaction

[Term]
id: GO:0052233
name: positive aerotaxis in other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive aerotaxis within other organism during symbiotic interaction" EXACT []
is_a: GO:0052220 ! positive aerotaxis in environment of other organism during symbiotic interaction
is_a: GO:0052237 ! aerotaxis in other organism during symbiotic interaction
is_a: GO:0052240 ! positive chemotaxis in other organism during symbiotic interaction
is_a: GO:0052247 ! positive energy taxis in other organism during symbiotic interaction

[Term]
id: GO:0052234
name: negative aerotaxis on or near other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052222 ! negative aerotaxis in environment of other organism during symbiotic interaction
is_a: GO:0052236 ! negative chemotaxis on or near other organism during symbiotic interaction
is_a: GO:0052238 ! aerotaxis on or near other organism during symbiotic interaction
is_a: GO:0052245 ! negative energy taxis on or near other organism during symbiotic interaction

[Term]
id: GO:0052235
name: negative aerotaxis in other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative aerotaxis within other organism during symbiotic interaction" EXACT []
is_a: GO:0052222 ! negative aerotaxis in environment of other organism during symbiotic interaction
is_a: GO:0052237 ! aerotaxis in other organism during symbiotic interaction
is_a: GO:0052239 ! negative chemotaxis in other organism during symbiotic interaction
is_a: GO:0052244 ! negative energy taxis in other organism during symbiotic interaction

[Term]
id: GO:0052236
name: negative chemotaxis on or near other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052223 ! negative chemotaxis in environment of other organism during symbiotic interaction
is_a: GO:0052243 ! chemotaxis on or near other organism during symbiotic interaction

[Term]
id: GO:0052237
name: aerotaxis in other organism during symbiotic interaction
namespace: biological_process
def: "The movement of a motile cell or organism in response to environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "aerotaxis within other organism during symbiotic interaction" EXACT []
is_a: GO:0052217 ! aerotaxis in environment of other organism during symbiotic interaction
is_a: GO:0052224 ! energy taxis in other organism during symbiotic interaction
is_a: GO:0052242 ! chemotaxis in other organism during symbiotic interaction

[Term]
id: GO:0052238
name: aerotaxis on or near other organism during symbiotic interaction
namespace: biological_process
def: "The movement of a motile cell or organism in response to environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052217 ! aerotaxis in environment of other organism during symbiotic interaction
is_a: GO:0052225 ! energy taxis on or near other organism during symbiotic interaction
is_a: GO:0052243 ! chemotaxis on or near other organism during symbiotic interaction

[Term]
id: GO:0052239
name: negative chemotaxis in other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative chemotaxis within other organism during symbiotic interaction" EXACT []
is_a: GO:0052223 ! negative chemotaxis in environment of other organism during symbiotic interaction
is_a: GO:0052242 ! chemotaxis in other organism during symbiotic interaction

[Term]
id: GO:0052240
name: positive chemotaxis in other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive chemotaxis within other organism during symbiotic interaction" EXACT []
is_a: GO:0052221 ! positive chemotaxis in environment of other organism during symbiotic interaction
is_a: GO:0052242 ! chemotaxis in other organism during symbiotic interaction

[Term]
id: GO:0052241
name: positive chemotaxis on or near other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052221 ! positive chemotaxis in environment of other organism during symbiotic interaction
is_a: GO:0052243 ! chemotaxis on or near other organism during symbiotic interaction

[Term]
id: GO:0052242
name: chemotaxis in other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "chemotaxis within other organism during symbiotic interaction" EXACT []
is_a: GO:0051814 ! movement in other organism during symbiotic interaction
is_a: GO:0052216 ! chemotaxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052243
name: chemotaxis on or near other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052195 ! movement on or near other organism during symbiotic interaction
is_a: GO:0052216 ! chemotaxis in environment of other organism during symbiotic interaction

[Term]
id: GO:0052244
name: negative energy taxis in other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism within a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "negative energy taxis within other organism during symbiotic interaction" EXACT []
is_a: GO:0052219 ! negative energy taxis in environment of other organism during symbiotic interaction
is_a: GO:0052224 ! energy taxis in other organism during symbiotic interaction

[Term]
id: GO:0052245
name: negative energy taxis on or near other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism on or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052219 ! negative energy taxis in environment of other organism during symbiotic interaction
is_a: GO:0052225 ! energy taxis on or near other organism during symbiotic interaction

[Term]
id: GO:0052246
name: positive energy taxis on or near other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism on or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052218 ! positive energy taxis in environment of other organism during symbiotic interaction
is_a: GO:0052225 ! energy taxis on or near other organism during symbiotic interaction

[Term]
id: GO:0052247
name: positive energy taxis in other organism during symbiotic interaction
namespace: biological_process
def: "The directed movement of a motile cell or organism within a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "positive energy taxis within other organism during symbiotic interaction" EXACT []
is_a: GO:0052218 ! positive energy taxis in environment of other organism during symbiotic interaction
is_a: GO:0052224 ! energy taxis in other organism during symbiotic interaction

[Term]
id: GO:0052248
name: modulation of programmed cell death in other organism during symbiotic interaction
namespace: biological_process
alt_id: GO:0052459
def: "Any process by which an organism modulates the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW []
is_a: GO:0043067 ! regulation of programmed cell death
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction

[Term]
id: GO:0052249
name: modulation of RNA levels in other organism during symbiotic interaction
namespace: biological_process
def: "The alteration by an organism of the levels of RNA in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction

[Term]
id: GO:0052250
name: modulation of signal transduction pathway in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the signal transduction pathways, the cascade of processes by which a signal interacts with a receptor, occurring in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction

[Term]
id: GO:0052251
name: induction by organism of defense response of other organism during symbiotic interaction
namespace: biological_process
def: "The activation by an organism of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc]
subset: gosubset_prok
synonym: "activation of defense response of other organism" EXACT []
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052252
name: negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of salicylic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism during symbiotic interaction" NARROW []
synonym: "negative modulation by organism of defense-related SA-mediated signal transduction pathway in other organism" EXACT []
synonym: "negative modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism" EXACT []
synonym: "negative regulation by organism of defense-related SA-mediated signal transduction pathway in other organism" EXACT []
is_a: GO:0052253 ! negative regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction
is_a: GO:0052445 ! modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction
is_a: GO:0052493 ! negative regulation by organism of signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052253
name: negative regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "negative regulation of SA-mediated defense response of other organism" EXACT []
synonym: "suppression by organism of salicylic acid-mediated defense response of other organism" EXACT []
synonym: "suppression of SA mediated defense response of other organism" EXACT []
is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction
is_a: GO:0052284 ! modulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction

[Term]
id: GO:0052254
name: negative regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the ethylene-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of ethylene-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "suppression by organism of ethylene-mediated defense response of other organism" EXACT []
is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction
is_a: GO:0052279 ! modulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction

[Term]
id: GO:0052255
name: modulation by organism of defense response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the defense response of a second organism, the response mounted by that organism in response to the presence of the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction
is_a: GO:0052173 ! response to defenses of other organism during symbiotic interaction

[Term]
id: GO:0052256
name: modulation by organism of inflammatory response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0050727 ! regulation of inflammatory response
is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052257
name: pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism during symbiotic interaction
namespace: biological_process
subset: gosubset_prok
synonym: "general elicitor dependent induction of innate immunity of other organism" EXACT []
synonym: "general elicitor-dependent induction of innate immunity of other organism" EXACT []
synonym: "MAMP dependent induction of innate immunity of other organism" EXACT []
synonym: "MAMP-dependent induction of innate immunity of other organism" EXACT []
synonym: "PAMP dependent induction of innate immunity of other organism" EXACT []
synonym: "PAMP-dependent induction of innate immunity of other organism" EXACT []
is_a: GO:0052305 ! positive regulation by organism of innate immunity in other organism during symbiotic interaction
is_a: GO:0052308 ! pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism during symbiotic interaction

[Term]
id: GO:0052258
name: negative regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction
namespace: biological_process
subset: gosubset_prok
synonym: "down regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of pathogen-associated molecular pattern-induced innate immunity of other organism during symbiotic interaction" NARROW []
synonym: "suppression of general elicitor induced innate immunity of other organism" EXACT []
synonym: "suppression of general elicitor-induced innate immunity of other organism" EXACT []
synonym: "suppression of MAMP induced innate immunity of other organism" EXACT []
synonym: "suppression of MAMP-induced innate immunity of other organism" EXACT []
synonym: "suppression of PAMP induced innate immunity of other organism" EXACT []
synonym: "suppression of PAMP-induced innate immunity of other organism" EXACT []
synonym: "suppression of pathogen-associated molecular pattern-induced innate immunity of other organism" EXACT []
is_a: GO:0052296 ! modulation by organism of pathogen-associated molecular pattern-induced innate immunity in other organism during symbiotic interaction
is_a: GO:0052309 ! negative regulation by organism of innate immunity in other organism during symbiotic interaction

[Term]
id: GO:0052259
name: positive regulation by organism of inflammatory response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of inflammatory response of other organism during symbiotic interaction" NARROW []
synonym: "stimulation by organism of inflammatory response of other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of inflammatory response of other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of inflammatory response of other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of inflammatory response of other organism during symbiotic interaction" EXACT []
is_a: GO:0050729 ! positive regulation of inflammatory response
is_a: GO:0052256 ! modulation by organism of inflammatory response of other organism during symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052260
name: negative regulation by organism of inflammatory response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the inflammatory response; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of inflammatory response of other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of inflammatory response of other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of inflammatory response of other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of inflammatory response of other organism during symbiotic interaction" NARROW []
is_a: GO:0050728 ! negative regulation of inflammatory response
is_a: GO:0052256 ! modulation by organism of inflammatory response of other organism during symbiotic interaction
is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052261
name: negative regulation by organism of defense response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of defense response of other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of defense response of other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of defense response of other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of defense response of other organism during symbiotic interaction" NARROW []
synonym: "suppression of defense response of other organism" EXACT []
is_a: GO:0031348 ! negative regulation of defense response
is_a: GO:0051833 ! suppression of defenses of other organism during symbiotic interaction
is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052262
name: induction by organism of phytoalexin production in other organism during symbiotic interaction
namespace: biological_process
def: "The activation by an organism of the production of phytoalexins that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of phytoalexin production in other organism during symbiotic interaction" EXACT []
is_a: GO:0052329 ! positive regulation by organism of phytoalexin production in other organism during symbiotic interaction
is_a: GO:0052558 ! induction by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052263
name: induction by organism of defense-related nitric oxide production in other organism during symbiotic interaction
namespace: biological_process
def: "The activation by an organism of the production of nitric oxide that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related nitric oxide production in other organism" EXACT []
synonym: "activation by organism of defense-related NO production in other organism" EXACT []
synonym: "induction by organism of defense-related NO production in other organism" EXACT []
is_a: GO:0052251 ! induction by organism of defense response of other organism during symbiotic interaction
is_a: GO:0052345 ! positive regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction
is_a: GO:0052558 ! induction by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052264
name: induction by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction
namespace: biological_process
def: "The activation by an organism of the production of reactive oxygen species that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related active oxygen species production in other organism" EXACT []
synonym: "activation by organism of defense-related AOS production in other organism" EXACT []
synonym: "activation by organism of defense-related metabolic burst in other organism" EXACT []
synonym: "activation by organism of defense-related oxidative burst in other organism" EXACT []
synonym: "activation by organism of defense-related reactive oxidative species production in other organism" EXACT []
synonym: "activation by organism of defense-related reactive oxygen intermediate production in other organism" EXACT []
synonym: "activation by organism of defense-related reactive oxygen species production in other organism" EXACT []
synonym: "activation by organism of defense-related respiratory burst in other organism" EXACT []
synonym: "activation by organism of defense-related ROI production in other organism" EXACT []
synonym: "activation by organism of defense-related ROS production in other organism" EXACT []
synonym: "induction by organism of defense-related active oxygen species production in other organism" EXACT []
synonym: "induction by organism of defense-related AOS production in other organism" EXACT []
synonym: "induction by organism of defense-related metabolic burst in other organism" EXACT []
synonym: "induction by organism of defense-related oxidative burst in other organism" EXACT []
synonym: "induction by organism of defense-related reactive oxidative species production in other organism" EXACT []
synonym: "induction by organism of defense-related reactive oxygen intermediate production in other organism" EXACT []
synonym: "induction by organism of defense-related respiratory burst in other organism" EXACT []
synonym: "induction by organism of defense-related ROI production in other organism" EXACT []
synonym: "induction by organism of defense-related ROS production in other organism" EXACT []
is_a: GO:0052251 ! induction by organism of defense response of other organism during symbiotic interaction
is_a: GO:0052348 ! positive regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction
is_a: GO:0052558 ! induction by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052265
name: induction by organism of defense-related calcium ion flux in other organism during symbiotic interaction
namespace: biological_process
def: "The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of Ca2+ flux of other organism" EXACT []
synonym: "activation by organism of defense-related calcium ion flux in other organism during symbiotic interaction" EXACT []
synonym: "induction by organism of Ca2+ flux of other organism" EXACT []
is_a: GO:0052065 ! positive regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction
is_a: GO:0052251 ! induction by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052266
name: negative regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "suppression by organism of JA-mediated defense response of other organism" EXACT []
is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction
is_a: GO:0052283 ! modulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction

[Term]
id: GO:0052267
name: negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of jasmonic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of defense-related JA-mediated signal transduction pathway in other organism" EXACT []
is_a: GO:0052266 ! negative regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction
is_a: GO:0052443 ! modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction
is_a: GO:0052493 ! negative regulation by organism of signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052268
name: negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of ethylene-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
is_a: GO:0052254 ! negative regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction
is_a: GO:0052441 ! modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction
is_a: GO:0052493 ! negative regulation by organism of signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052269
name: positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of ethylene-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW []
synonym: "activation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW []
synonym: "stimulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW []
synonym: "upregulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
is_a: GO:0052274 ! positive regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction
is_a: GO:0052441 ! modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction
is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052270
name: positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of salicylic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW []
synonym: "activation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism" NARROW []
synonym: "activation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW []
synonym: "induction by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism" NARROW []
synonym: "positive regulation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW []
synonym: "stimulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW []
synonym: "upregulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism" NARROW []
synonym: "upregulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
is_a: GO:0052272 ! positive regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction
is_a: GO:0052445 ! modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction
is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052271
name: positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of jasmonic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism" NARROW []
synonym: "activation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "activation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW []
synonym: "induction by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism" NARROW []
synonym: "induction by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW []
synonym: "positive regulation by organism of defense-related SA-mediated signal transduction pathway in other organism" EXACT []
synonym: "stimulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism" NARROW []
synonym: "upregulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of defense-related SA-mediated signal transduction pathway in other organism" NARROW []
is_a: GO:0052273 ! positive regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction
is_a: GO:0052443 ! modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction
is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052272
name: positive regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of SA-mediated defense response of other organism" NARROW []
synonym: "induction by organism of salicylic acid-mediated defense response of other organism" NARROW []
synonym: "positive regulation by organism of SA-mediated defense response of other organism" EXACT []
synonym: "stimulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction" EXACT []
is_a: GO:0052284 ! modulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052273
name: positive regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of JA-mediated defense response of other organism" NARROW []
synonym: "induction by organism of jasmonic acid-mediated defense response of other organism" NARROW []
synonym: "positive regulation by organism of JA-mediated defense response of other organism" EXACT []
synonym: "stimulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction" EXACT []
is_a: GO:0052283 ! modulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052274
name: positive regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of ethylene-mediated defense response of other organism" NARROW []
synonym: "activation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of ethylene-mediated defense response of other organism" NARROW []
synonym: "stimulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of ethylene-mediated defense response of other organism" NARROW []
synonym: "upregulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction" EXACT []
is_a: GO:0052279 ! modulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052275
name: negative regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of MAP kinase-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of defense-related MAPK-mediated signal transduction pathway in other organism" EXACT []
synonym: "negative regulation by organism of defense-related mitogen-activated protein kinase-mediated signal transduction pathway in other organism" EXACT []
is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052276
name: positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of MAP kinase-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW []
synonym: "activation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW []
synonym: "positive regulation by organism of defense-related MAPK-mediated signal transduction pathway in other organism" EXACT []
synonym: "positive regulation by organism of defense-related mitogen-activated protein kinase-mediated signal transduction pathway in other organism" EXACT []
synonym: "stimulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism" NARROW []
synonym: "upregulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction" EXACT []
is_a: GO:0052277 ! modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction
is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052277
name: modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of MAP kinase-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of defense-related MAPK-mediated signal transduction pathway of other organism" EXACT []
synonym: "modulation of defense-related mitogen activated protein kinase-mediated signal transduction pathway of other organism" EXACT []
is_a: GO:0052250 ! modulation of signal transduction pathway in other organism during symbiotic interaction
is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052278
name: negative regulation by organism of cell-mediated immune response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the cell-based immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of cell-mediated immune response of other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of cell-mediated immune response of other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of cell-mediated immune response of other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of cell-mediated immune response of other organism during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of cell-based immune response of other organism during symbiotic interaction" EXACT []
is_a: GO:0052294 ! modulation by organism of cell-mediated immune response of other organism during symbiotic interaction
is_a: GO:0052561 ! negative regulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052279
name: modulation by organism of ethylene-mediated defense response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052280
name: negative regulation by organism of T-cell mediated immune response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the T-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of T-cell mediated immune response of other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of T-cell mediated immune response of other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of T-cell mediated immune response of other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of T-cell mediated immune response of other organism during symbiotic interaction" NARROW []
is_a: GO:0052278 ! negative regulation by organism of cell-mediated immune response of other organism during symbiotic interaction
is_a: GO:0052295 ! modulation by organism of T-cell mediated immune response of other organism during symbiotic interaction

[Term]
id: GO:0052281
name: negative regulation by organism of B-cell mediated immune response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the B-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of B-cell mediated immune response of other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of B-cell mediated immune response of other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of B-cell mediated immune response of other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of B-cell mediated immune response of other organism during symbiotic interaction" NARROW []
is_a: GO:0052293 ! modulation by organism of B-cell mediated immune response of other organism during symbiotic interaction
is_a: GO:0052561 ! negative regulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052282
name: negative regulation by organism of defense-related callose deposition in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the accumulation of callose that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of defense-related callose deposition in other organism during symbiotic interaction" NARROW []
synonym: "suppression by organism of defense-related callose deposition of other organism" EXACT []
is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction
is_a: GO:0052285 ! modulation by organism of defense-related callose deposition of other organism during symbiotic interaction

[Term]
id: GO:0052283
name: modulation by organism of jasmonic acid-mediated defense response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of JA-mediated defense response of other organism" EXACT []
is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052284
name: modulation by organism of salicylic acid-mediated defense response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of SA-mediated defense response of other organism" EXACT []
is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052285
name: modulation by organism of defense-related callose deposition of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the accumulation of callose that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052286
name: induction by organism of resistance gene-dependent defense response of other organism during symbiotic interaction
namespace: biological_process
def: "The activation by an organism of the resistance gene-dependent defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense response of other organism by specific elicitors" EXACT []
synonym: "activation by organism of gene-for-gene resistance in other organism" EXACT []
synonym: "activation by organism of resistance gene-dependent defense response of other organism" EXACT []
synonym: "induction by organism of defense response of other organism by specific elicitors" EXACT []
synonym: "induction by organism of gene-for-gene resistance in other organism" EXACT []
is_a: GO:0052423 ! positive regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction
is_a: GO:0052558 ! induction by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052287
name: positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of calcium-dependent protein kinase pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of defense-related CDPK pathway of other organism" EXACT []
synonym: "stimulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction" EXACT []
is_a: GO:0050850 ! positive regulation of calcium-mediated signaling
is_a: GO:0052307 ! modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052288
name: induction by organism of induced systemic resistance in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates induced systemic resistance, a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of induced systemic resistance in other organism during symbiotic interaction" EXACT []
synonym: "activation by organism of ISR in other organism" EXACT []
synonym: "induction by organism of ISR in other organism" EXACT []
is_a: GO:0052382 ! induction by organism of innate immunity in other organism during symbiotic interaction
is_a: GO:0052532 ! positive regulation by organism of induced systemic resistance in other organism during symbiotic interaction

[Term]
id: GO:0052289
name: induction by organism of systemic acquired resistance in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates systemic acquired resistance, a salicylic acid-mediated response that confers broad spectrum systemic resistance, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of SAR in other organism" EXACT []
synonym: "activation by organism of systemic acquired resistance in other organism" EXACT []
synonym: "induction by organism of SAR in other organism" EXACT []
is_a: GO:0052382 ! induction by organism of innate immunity in other organism during symbiotic interaction
is_a: GO:0052535 ! positive regulation by organism of systemic acquired resistance in other organism during symbiotic interaction

[Term]
id: GO:0052290
name: induction by organism of defense-related cell wall thickening in other organism during symbiotic interaction
namespace: biological_process
def: "The activation by an organism of the thickening of cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" EXACT []
synonym: "activation by organism of defensive cell wall thickening in other organism during symbiotic interaction" EXACT []
synonym: "induction by organism of defensive cell wall thickening in other organism during symbiotic interaction" EXACT []
is_a: GO:0052251 ! induction by organism of defense response of other organism during symbiotic interaction
is_a: GO:0052538 ! positive regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction

[Term]
id: GO:0052291
name: positive regulation by organism of defense-related callose deposition in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the accumulation of callose that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related callose deposition in other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of defense-related callose deposition of other organism" NARROW []
synonym: "induction by organism of defense-related papilla formation in other organism" NARROW []
synonym: "positive regulation by organism of defense-related papilla formation in other organism" EXACT []
synonym: "stimulation by organism of defense-related callose deposition in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of defense-related callose deposition in other organism during symbiotic interaction" EXACT []
is_a: GO:0052285 ! modulation by organism of defense-related callose deposition of other organism during symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052292
name: positive regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the deposition by a second organism of callose in its cell walls, occurring as part of the defense response, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" NARROW []
synonym: "induction by organism of defense-related cell wall callose deposition in other organism" NARROW []
synonym: "stimulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" EXACT []
is_a: GO:0052291 ! positive regulation by organism of defense-related callose deposition in other organism during symbiotic interaction
is_a: GO:0052310 ! modulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction
is_a: GO:0052538 ! positive regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction

[Term]
id: GO:0052293
name: modulation by organism of B-cell mediated immune response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "regulation by organism of B-cell mediated immune response of other organism" EXACT []
is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052294
name: modulation by organism of cell-mediated immune response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of any form of cell-based immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of cell-based immune response of other organism during symbiotic interaction" EXACT []
is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052295
name: modulation by organism of T-cell mediated immune response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052294 ! modulation by organism of cell-mediated immune response of other organism during symbiotic interaction

[Term]
id: GO:0052296
name: modulation by organism of pathogen-associated molecular pattern-induced innate immunity in other organism during symbiotic interaction
namespace: biological_process
is_a: GO:0052306 ! modulation by organism of innate immunity in other organism during symbiotic interaction

[Term]
id: GO:0052297
name: modulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the resistance gene-dependent defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense response in other organism by specific elicitors" EXACT []
synonym: "modulation by organism of gene-for-gene resistance in other organism" EXACT []
is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052298
name: modulation by organism of induced systemic resistance in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of induced systemic resistance, a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0052306 ! modulation by organism of innate immunity in other organism during symbiotic interaction

[Term]
id: GO:0052299
name: modulation by organism of systemic acquired resistance in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of systemic acquired resistance, a salicylic acid-mediated response that confers broad spectrum systemic resistance, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0010112 ! regulation of systemic acquired resistance
is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052300
name: modulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the thickening of cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defensive cell wall thickening in other organism during symbiotic interaction" RELATED []
is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052301
name: modulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related Ca2+ flux in other organism during symbiotic interaction" EXACT []
is_a: GO:0050848 ! regulation of calcium-mediated signaling
is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052302
name: modulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the production of nitric oxide that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related NO production in other organism during symbiotic interaction" EXACT []
is_a: GO:0052551 ! response to defense-related nitric oxide production by other organism during symbiotic interaction
is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052303
name: modulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the production of reactive oxygen species that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related active oxygen species production in other organism" EXACT []
synonym: "modulation by organism of defense-related AOS production in other organism" EXACT []
synonym: "modulation by organism of defense-related metabolic burst in other organism" EXACT []
synonym: "modulation by organism of defense-related oxidative burst in other organism" EXACT []
synonym: "modulation by organism of defense-related reactive oxidative species production in other organism" EXACT []
synonym: "modulation by organism of defense-related reactive oxygen intermediate production in other organism" EXACT []
synonym: "modulation by organism of defense-related respiratory burst in other organism" EXACT []
synonym: "modulation by organism of defense-related ROI production in other organism" EXACT []
synonym: "modulation by organism of defense-related ROS production in other organism" EXACT []
is_a: GO:0052550 ! response to defense-related reactive oxygen species production by other organism during symbiotic interaction
is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052304
name: modulation by organism of phytoalexin production in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of production of phytoalexins that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052549 ! response to phytoalexin production by other organism during symbiotic interaction
is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052305
name: positive regulation by organism of innate immunity in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of innate immunity in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation of innate immune response of other organism" EXACT []
synonym: "stimulation by organism of innate immunity in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of innate immunity in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of innate immunity in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of innate immunity in other organism during symbiotic interaction" EXACT []
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0052306 ! modulation by organism of innate immunity in other organism during symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction
is_a: GO:0052555 ! positive regulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052306
name: modulation by organism of innate immunity in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of innate immune response of other organism" EXACT []
is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052307
name: modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of calcium-dependent protein kinase signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of defense-related CDPK pathway in other organism during symbiotic interaction" EXACT []
is_a: GO:0050848 ! regulation of calcium-mediated signaling
is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052308
name: pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism during symbiotic interaction
namespace: biological_process
is_a: GO:0052306 ! modulation by organism of innate immunity in other organism during symbiotic interaction

[Term]
id: GO:0052309
name: negative regulation by organism of innate immunity in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of innate immunity in other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of innate immunity in other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of innate immunity in other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of innate immunity in other organism during symbiotic interaction" NARROW []
synonym: "negative regulation of innate immune response of other organism" EXACT []
is_a: GO:0052261 ! negative regulation by organism of defense response of other organism during symbiotic interaction
is_a: GO:0052306 ! modulation by organism of innate immunity in other organism during symbiotic interaction
is_a: GO:0052561 ! negative regulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052310
name: modulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the accumulation of callose in cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052285 ! modulation by organism of defense-related callose deposition of other organism during symbiotic interaction
is_a: GO:0052300 ! modulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction

[Term]
id: GO:0052311
name: negative regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the accumulation of callose in cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction" NARROW []
is_a: GO:0052282 ! negative regulation by organism of defense-related callose deposition in other organism during symbiotic interaction
is_a: GO:0052310 ! modulation by organism of defense-related cell wall callose deposition in other organism during symbiotic interaction

[Term]
id: GO:0052312
name: modulation of transcription in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0045449 ! regulation of transcription
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction

[Term]
id: GO:0052313
name: modulation of nutrient release from other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction
relationship: part_of GO:0051816 ! acquisition of nutrients from other organism during symbiotic interaction

[Term]
id: GO:0052314
name: phytoalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response." [Wikipedia:Phytoalexin]
subset: goslim_pir
subset: gosubset_prok
synonym: "phytoalexin metabolism" EXACT []
is_a: GO:0044237 ! cellular metabolic process

[Term]
id: GO:0052315
name: phytoalexin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response." [Wikipedia:Phytoalexin]
synonym: "phytoalexin biosynthesis" EXACT []
is_a: GO:0044249 ! cellular biosynthetic process
is_a: GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0052316
name: phytoalexin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of phytoalexins, any of a range of substances produced by plants as part of their defense response." [GOC:ai]
synonym: "phytoalexin catabolism" EXACT []
is_a: GO:0044248 ! cellular catabolic process
is_a: GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0052317
name: camalexin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving camalexin, an indole phytoalexin." [GOC:ai]
synonym: "camalexin metabolism" EXACT []
is_a: GO:0006790 ! sulfur metabolic process
is_a: GO:0046217 ! indole phytoalexin metabolic process

[Term]
id: GO:0052318
name: regulation of phytoalexin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response." [GOC:ai]
synonym: "regulation of phytoalexin metabolism" EXACT []
is_a: GO:0031323 ! regulation of cellular metabolic process
relationship: regulates GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0052319
name: regulation of phytoalexin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:ai]
synonym: "regulation of phytoalexin biosynthesis" EXACT []
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0052318 ! regulation of phytoalexin metabolic process
relationship: regulates GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0052320
name: positive regulation of phytoalexin metabolic process
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins." [GOC:mtg_pamgo_17jul06]
synonym: "activation of phytoalexin metabolism" NARROW []
synonym: "positive regulation of phytoalexin metabolism" RELATED []
synonym: "stimulation of phytoalexin metabolism" NARROW []
synonym: "up regulation of phytoalexin metabolism" EXACT []
synonym: "up-regulation of phytoalexin metabolism" EXACT []
synonym: "upregulation of phytoalexin metabolism" EXACT []
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0052318 ! regulation of phytoalexin metabolic process
relationship: positively_regulates GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0052321
name: negative regulation of phytoalexin metabolic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins." [GOC:ai]
synonym: "down regulation of phytoalexin metabolism" EXACT []
synonym: "down-regulation of phytoalexin metabolism" EXACT []
synonym: "downregulation of phytoalexin metabolism" EXACT []
synonym: "inhibition of phytoalexin metabolism" NARROW []
synonym: "negative regulation of phytoalexin metabolism" EXACT []
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0052318 ! regulation of phytoalexin metabolic process
relationship: negatively_regulates GO:0052314 ! phytoalexin metabolic process

[Term]
id: GO:0052322
name: positive regulation of phytoalexin biosynthetic process
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:mtg_pamgo_17jul06]
synonym: "activation of phytoalexin biosynthesis" NARROW []
synonym: "positive regulation of phytoalexin biosynthesis" EXACT []
synonym: "stimulation of phytoalexin biosynthesis" NARROW []
synonym: "up regulation of phytoalexin biosynthesis" EXACT []
synonym: "up-regulation of phytoalexin biosynthesis" EXACT []
synonym: "upregulation of phytoalexin biosynthesis" EXACT []
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0052319 ! regulation of phytoalexin biosynthetic process
is_a: GO:0052320 ! positive regulation of phytoalexin metabolic process
relationship: positively_regulates GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0052323
name: negative regulation of phytoalexin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:ai]
synonym: "down regulation of phytoalexin biosynthesis" EXACT []
synonym: "down-regulation of phytoalexin biosynthesis" EXACT []
synonym: "downregulation of phytoalexin biosynthesis" EXACT []
synonym: "inhibition of phytoalexin biosynthesis" NARROW []
synonym: "negative regulation of phytoalexin biosynthesis" EXACT []
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0052319 ! regulation of phytoalexin biosynthetic process
is_a: GO:0052321 ! negative regulation of phytoalexin metabolic process
relationship: negatively_regulates GO:0052315 ! phytoalexin biosynthetic process

[Term]
id: GO:0052324
name: cell wall cellulose biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall." [GOC:ai]
synonym: "cell wall cellulose biosynthesis" EXACT []
synonym: "cellulose biosynthesis during cell wall biosynthesis" RELATED []
is_a: GO:0030244 ! cellulose biosynthetic process
is_a: GO:0052541 ! plant-type cell wall cellulose metabolic process
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process
relationship: part_of GO:0009832 ! plant-type cell wall biogenesis

[Term]
id: GO:0052325
name: cell wall pectin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall." [GOC:ai]
synonym: "cell wall pectin biosynthesis" EXACT []
synonym: "pectin biosynthesis during cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045489 ! pectin biosynthetic process
is_a: GO:0052546 ! cell wall pectin metabolic process
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process
relationship: part_of GO:0009832 ! plant-type cell wall biogenesis

[Term]
id: GO:0052326
name: interaction with symbiont via protein secreted by type IV secretion system
namespace: biological_process
def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type IV secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052327
name: interaction with symbiont via protein secreted by type II secretion system
namespace: biological_process
def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type II secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052328
name: interaction with symbiont via protein secreted by type III secretion system
namespace: biological_process
def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type III secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052329
name: positive regulation by organism of phytoalexin production in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of phytoalexin production in other organism during symbiotic interaction" NARROW []
synonym: "stimulation by organism of phytoalexin production in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of phytoalexin production in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of phytoalexin production in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of phytoalexin production in other organism during symbiotic interaction" EXACT []
is_a: GO:0052304 ! modulation by organism of phytoalexin production in other organism during symbiotic interaction
is_a: GO:0052555 ! positive regulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052330
name: positive regulation by organism of programmed cell death in other organism during symbiotic interaction
namespace: biological_process
alt_id: GO:0052518
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of programmed cell death in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW []
synonym: "stimulation by organism of programmed cell death in other organism during symbiotic interaction" NARROW []
is_a: GO:0043068 ! positive regulation of programmed cell death
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
is_a: GO:0051712 ! positive regulation of killing of cells of another organism
is_a: GO:0052248 ! modulation of programmed cell death in other organism during symbiotic interaction
relationship: positively_regulates GO:0051883 ! killing of cells in other organism during symbiotic interaction

[Term]
id: GO:0052331
name: hemolysis of cells in other organism during symbiotic interaction
namespace: biological_process
def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another, where two organisms are in a symbiotic interaction." [GOC:add, SP_KW:KW-0354]
subset: gosubset_prok
synonym: "haemolysis in other organism" EXACT []
synonym: "hemolysin activity" RELATED []
synonym: "hemolysis by organism of erythrocytes in other organism during symbiotic interaction" EXACT []
synonym: "hemolysis by organism of RBCs in other organism during symbiotic interaction" EXACT [CL:0000232]
synonym: "hemolysis by organism of red blood cells in other organism during symbiotic interaction" EXACT [CL:0000232]
is_a: GO:0044179 ! hemolysis of cells in other organism
is_a: GO:0051801 ! cytolysis of cells in other organism during symbiotic interaction

[Term]
id: GO:0052332
name: modification by organism of cell membrane in other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of the cell membrane of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052188 ! modification of cellular component in other organism during symbiotic interaction

[Term]
id: GO:0052333
name: modification by organism of cell wall of other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "metabolism by organism of cell wall of other organism" RELATED []
is_a: GO:0052188 ! modification of cellular component in other organism during symbiotic interaction

[Term]
id: GO:0052334
name: modification by organism of cytoskeleton of other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of the cytoskeleton of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052188 ! modification of cellular component in other organism during symbiotic interaction

[Term]
id: GO:0052335
name: modification by host of symbiont cytoskeleton
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of the symbiont cytoskeleton. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052187 ! modification by host of symbiont cellular component
is_a: GO:0052334 ! modification by organism of cytoskeleton of other organism during symbiotic interaction

[Term]
id: GO:0052336
name: modification by host of symbiont cell wall
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "metabolism of symbiont cell wall by organism" EXACT []
is_a: GO:0052187 ! modification by host of symbiont cellular component
is_a: GO:0052333 ! modification by organism of cell wall of other organism during symbiotic interaction

[Term]
id: GO:0052337
name: modification by host of symbiont cell membrane
namespace: biological_process
def: "The process by which an organism effects a change in the structure or function of the symbiont cell membrane. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052187 ! modification by host of symbiont cellular component
is_a: GO:0052332 ! modification by organism of cell membrane in other organism during symbiotic interaction

[Term]
id: GO:0052338
name: disassembly by host of symbiont cell wall
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism of symbiont cell wall by organism" EXACT []
synonym: "degradation of symbiont cell wall by organism" EXACT []
is_a: GO:0052336 ! modification by host of symbiont cell wall
is_a: GO:0052339 ! disassembly by organism of cell wall of other organism during symbiotic interaction
is_a: GO:0052367 ! disassembly by host of symbiont cellular component

[Term]
id: GO:0052339
name: disassembly by organism of cell wall of other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052333 ! modification by organism of cell wall of other organism during symbiotic interaction

[Term]
id: GO:0052340
name: catabolism by organism of cell wall cellulose in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0016998 ! cell wall macromolecule catabolic process
is_a: GO:0030245 ! cellulose catabolic process
is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism during symbiotic interaction
is_a: GO:0052409 ! metabolism by organism of cell wall cellulose in other organism during symbiotic interaction
relationship: part_of GO:0044278 ! cell wall disassembly in other organism
relationship: part_of GO:0052339 ! disassembly by organism of cell wall of other organism during symbiotic interaction

[Term]
id: GO:0052341
name: catabolism by organism of cell wall pectin in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0016998 ! cell wall macromolecule catabolic process
is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism during symbiotic interaction
is_a: GO:0052413 ! metabolism by organism of cell wall pectin in other organism during symbiotic interaction
relationship: part_of GO:0044278 ! cell wall disassembly in other organism
relationship: part_of GO:0052339 ! disassembly by organism of cell wall of other organism during symbiotic interaction

[Term]
id: GO:0052342
name: catabolism by organism of cell wall chitin in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
is_a: GO:0006039 ! cell wall chitin catabolic process
is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism during symbiotic interaction
is_a: GO:0052411 ! metabolism by organism of cell wall chitin in other organism during symbiotic interaction
relationship: part_of GO:0052339 ! disassembly by organism of cell wall of other organism during symbiotic interaction

[Term]
id: GO:0052343
name: positive regulation by organism of symbiont phytoalexin production
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052344
name: positive regulation by symbiont of host phytoalexin production
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host phytoalexin production" NARROW []
synonym: "stimulation by symbiont of host phytoalexin production" NARROW []
synonym: "up regulation by symbiont of host phytoalexin production" EXACT []
synonym: "up-regulation by symbiont of host phytoalexin production" EXACT []
synonym: "upregulation by symbiont of host phytoalexin production" EXACT []
is_a: GO:0052165 ! modulation by symbiont of host phytoalexin production
is_a: GO:0052329 ! positive regulation by organism of phytoalexin production in other organism during symbiotic interaction
is_a: GO:0052556 ! positive regulation by symbiont of host immune response

[Term]
id: GO:0052345
name: positive regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of defense-related NO production in other organism during symbiotic interaction" EXACT []
synonym: "stimulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction" EXACT []
is_a: GO:0052302 ! modulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction
is_a: GO:0052555 ! positive regulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052346
name: positive regulation by organism of defense-related symbiont nitric oxide production
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of defense-related symbiont NO production" EXACT []
is_obsolete: true

[Term]
id: GO:0052347
name: positive regulation by symbiont of defense-related host nitric oxide production
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of defense-related host nitric oxide production" NARROW []
synonym: "positive regulation by organism of defense-related host NO production" EXACT []
synonym: "stimulation by symbiont of defense-related host nitric oxide production" NARROW []
synonym: "up regulation by symbiont of defense-related host nitric oxide production" EXACT []
synonym: "up-regulation by symbiont of defense-related host nitric oxide production" EXACT []
synonym: "upregulation by symbiont of defense-related host nitric oxide production" EXACT []
is_a: GO:0052163 ! modulation by symbiont of defense-related host nitric oxide production
is_a: GO:0052345 ! positive regulation by organism of defense-related nitric oxide production in other organism during symbiotic interaction
is_a: GO:0052556 ! positive regulation by symbiont of host immune response

[Term]
id: GO:0052348
name: positive regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of defense-related active oxygen species production in other organism" EXACT []
synonym: "positive regulation by organism of defense-related AOS production in other organism" EXACT []
synonym: "positive regulation by organism of defense-related metabolic burst in other organism" EXACT []
synonym: "positive regulation by organism of defense-related oxidative burst in other organism" EXACT []
synonym: "positive regulation by organism of defense-related reactive oxidative species production in other organism" EXACT []
synonym: "positive regulation by organism of defense-related reactive oxygen intermediate production in other organism" EXACT []
synonym: "positive regulation by organism of defense-related respiratory burst in other organism" EXACT []
synonym: "positive regulation by organism of defense-related ROI production in other organism" EXACT []
synonym: "positive regulation by organism of defense-related ROS production in other organism" EXACT []
synonym: "stimulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction" EXACT []
is_a: GO:0052303 ! modulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction
is_a: GO:0052555 ! positive regulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052349
name: positive regulation by organism of defense-related symbiont reactive oxygen species production
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of defense-related symbiont active oxygen species production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont AOS production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont metabolic burst" EXACT []
synonym: "positive regulation by organism of defense-related symbiont oxidative burst" EXACT []
synonym: "positive regulation by organism of defense-related symbiont reactive oxidative species production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont respiratory burst" EXACT []
synonym: "positive regulation by organism of defense-related symbiont ROI production" EXACT []
synonym: "positive regulation by organism of defense-related symbiont ROS production" EXACT []
is_obsolete: true

[Term]
id: GO:0052350
name: induction by organism of induced systemic resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates induced systemic resistance in the symbiont; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of induced systemic resistance in symbiont" EXACT []
synonym: "activation by organism of ISR in symbiont" EXACT []
synonym: "induction by organism of ISR in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052351
name: induction by organism of systemic acquired resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of SAR in symbiont" EXACT []
synonym: "activation by organism of systemic acquired resistance in symbiont" EXACT []
synonym: "induction by organism of SAR in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052352
name: biosynthesis by host of substance in symbiont
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in its symbiont resulting in the formation of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052226 ! biosynthesis of substance in other organism during symbiotic interaction
is_a: GO:0052419 ! metabolism by host of substance in symbiont

[Term]
id: GO:0052353
name: catabolism by host of symbiont carbohydrate
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism during symbiotic interaction
is_a: GO:0052360 ! catabolism by host of symbiont macromolecule
is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate

[Term]
id: GO:0052354
name: catabolism by organism of carbohydrate in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0044041 ! multi-organism carbohydrate catabolic process
is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism during symbiotic interaction
is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism during symbiotic interaction

[Term]
id: GO:0052355
name: catabolism by host of symbiont cell wall cellulose
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052340 ! catabolism by organism of cell wall cellulose in other organism during symbiotic interaction
is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate
is_a: GO:0052408 ! metabolism by host of symbiont cell wall cellulose
relationship: part_of GO:0052338 ! disassembly by host of symbiont cell wall

[Term]
id: GO:0052356
name: catabolism by host of symbiont cell wall chitin
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052342 ! catabolism by organism of cell wall chitin in other organism during symbiotic interaction
is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate
is_a: GO:0052410 ! metabolism by host of symbiont cell wall chitin
relationship: part_of GO:0052338 ! disassembly by host of symbiont cell wall

[Term]
id: GO:0052357
name: catabolism by host of symbiont cell wall pectin
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052341 ! catabolism by organism of cell wall pectin in other organism during symbiotic interaction
is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate
is_a: GO:0052412 ! metabolism by host of symbiont cell wall pectin
relationship: part_of GO:0052338 ! disassembly by host of symbiont cell wall

[Term]
id: GO:0052358
name: catabolism by host of symbiont glucan
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate
is_a: GO:0052359 ! catabolism by organism of glucan in other organism during symbiotic interaction
is_a: GO:0052414 ! metabolism by host of symbiont glucan

[Term]
id: GO:0052359
name: catabolism by organism of glucan in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism during symbiotic interaction
is_a: GO:0052415 ! metabolism by organism of glucan in other organism during symbiotic interaction

[Term]
id: GO:0052360
name: catabolism by host of symbiont macromolecule
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism during symbiotic interaction
is_a: GO:0052364 ! catabolism by host of substance in symbiont
is_a: GO:0052416 ! metabolism by host of symbiont macromolecule

[Term]
id: GO:0052361
name: catabolism by organism of macromolecule in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0009057 ! macromolecule catabolic process
is_a: GO:0052227 ! catabolism of substance in other organism during symbiotic interaction
is_a: GO:0052229 ! metabolism of macromolecule in other organism during symbiotic interaction

[Term]
id: GO:0052362
name: catabolism by host of symbiont protein
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052360 ! catabolism by host of symbiont macromolecule
is_a: GO:0052363 ! catabolism by organism of protein in other organism during symbiotic interaction
is_a: GO:0052417 ! metabolism by host of symbiont protein

[Term]
id: GO:0052363
name: catabolism by organism of protein in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0030163 ! protein catabolic process
is_a: GO:0052361 ! catabolism by organism of macromolecule in other organism during symbiotic interaction
is_a: GO:0052418 ! metabolism by organism of protein in other organism during symbiotic interaction

[Term]
id: GO:0052364
name: catabolism by host of substance in symbiont
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in its symbiont resulting in the breakdown of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052227 ! catabolism of substance in other organism during symbiotic interaction
is_a: GO:0052419 ! metabolism by host of substance in symbiont

[Term]
id: GO:0052365
name: catabolism by host of symbiont xylan
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0052353 ! catabolism by host of symbiont carbohydrate
is_a: GO:0052366 ! catabolism by organism of xylan in other organism during symbiotic interaction
is_a: GO:0052420 ! metabolism by host of symbiont xylan

[Term]
id: GO:0052366
name: catabolism by organism of xylan in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
is_a: GO:0045493 ! xylan catabolic process
is_a: GO:0052354 ! catabolism by organism of carbohydrate in other organism during symbiotic interaction
is_a: GO:0052421 ! metabolism by organism of xylan in other organism during symbiotic interaction

[Term]
id: GO:0052367
name: disassembly by host of symbiont cellular component
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684]
synonym: "catabolism of symbiont cellular component by organism" EXACT []
synonym: "catabolism of symbiont structural constituent by organism" EXACT []
synonym: "degradation of symbiont cellular component by organism" EXACT []
is_a: GO:0052187 ! modification by host of symbiont cellular component
is_a: GO:0052368 ! disassembly by organism of cellular component in other organism during symbiotic interaction

[Term]
id: GO:0052368
name: disassembly by organism of cellular component in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684]
subset: gosubset_prok
synonym: "catabolism of cellular component in other organism" EXACT []
synonym: "catabolism of structural constituent in other organism" EXACT []
synonym: "degradation of cellular component in other organism" EXACT []
is_a: GO:0052185 ! modification of structure of other organism during symbiotic interaction

[Term]
id: GO:0052369
name: positive regulation by symbiont of defense-related host reactive oxygen species production
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of defense-related host reactive oxygen species production" NARROW []
synonym: "positive regulation by organism of defense-related host active oxygen species production" EXACT []
synonym: "positive regulation by organism of defense-related host AOS production" EXACT []
synonym: "positive regulation by organism of defense-related host metabolic burst" EXACT []
synonym: "positive regulation by organism of defense-related host oxidative burst" EXACT []
synonym: "positive regulation by organism of defense-related host reactive oxidative species production" EXACT []
synonym: "positive regulation by organism of defense-related host reactive oxygen intermediate production" EXACT []
synonym: "positive regulation by organism of defense-related host respiratory burst" EXACT []
synonym: "positive regulation by organism of defense-related host ROI production" EXACT []
synonym: "positive regulation by organism of defense-related host ROS production" EXACT []
synonym: "stimulation by symbiont of defense-related host reactive oxygen species production" NARROW []
synonym: "up regulation by symbiont of defense-related host reactive oxygen species production" EXACT []
synonym: "up-regulation by symbiont of defense-related host reactive oxygen species production" EXACT []
synonym: "upregulation by symbiont of defense-related host reactive oxygen species production" EXACT []
is_a: GO:0052164 ! modulation by symbiont of defense-related host reactive oxygen species production
is_a: GO:0052348 ! positive regulation by organism of defense-related reactive oxygen species production in other organism during symbiotic interaction
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:0052556 ! positive regulation by symbiont of host immune response

[Term]
id: GO:0052370
name: entry of organism into cell of other organism by promotion of phagocytosis in other organism during symbiotic interaction
namespace: biological_process
def: "The invasion by an organism of a cell of a second organism by utilizing the second organism's phagocytosis mechanism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051806 ! entry into cell of other organism during symbiotic interaction
is_a: GO:0052522 ! positive regulation by organism of phagocytosis in other organism during symbiotic interaction

[Term]
id: GO:0052371
name: regulation by organism of entry into other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of entry into other organism during symbiotic interaction" EXACT []
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
relationship: regulates GO:0051828 ! entry into other organism during symbiotic interaction

[Term]
id: GO:0052372
name: modulation by symbiont of entry into host
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052371 ! regulation by organism of entry into other organism during symbiotic interaction

[Term]
id: GO:0052373
name: negative regulation by organism of entry into other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by organism of entry into other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of entry into other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of entry into other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of entry into other organism during symbiotic interaction" NARROW []
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0052371 ! regulation by organism of entry into other organism during symbiotic interaction

[Term]
id: GO:0052374
name: negative regulation by symbiont of entry into host
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by symbiont of entry into host" EXACT []
synonym: "down-regulation by symbiont of entry into host" EXACT []
synonym: "downregulation by symbiont of entry into host" EXACT []
synonym: "inhibition by symbiont of entry into host" NARROW []
is_a: GO:0052372 ! modulation by symbiont of entry into host
is_a: GO:0052373 ! negative regulation by organism of entry into other organism during symbiotic interaction

[Term]
id: GO:0052375
name: evasion or tolerance by organism of symbiont-produced nitric oxide
namespace: biological_process
def: "OBSOLETE. The process by which an organism avoids the effects of nitric oxide produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "evasion or tolerance by organism of symbiont nitric oxide" EXACT []
synonym: "evasion or tolerance by organism of symbiont NO" EXACT []
synonym: "evasion or tolerance by organism of symbiont-produced NO" EXACT []
synonym: "evasion or tolerance of nitric oxide produced by symbiont in response to organism" EXACT []
synonym: "evasion or tolerance of NO produced by symbiont in response to organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052376
name: evasion or tolerance by organism of nitric oxide produced by other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism avoids the effects of nitric oxide produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "evasion or tolerance by organism of NO produced by other organism during symbiotic interaction" EXACT []
synonym: "evasion or tolerance by organism of other organism-produced nitric oxide" EXACT []
synonym: "evasion or tolerance by organism of other organism-produced NO" EXACT []
is_a: GO:0051805 ! evasion or tolerance of immune response of other organism during symbiotic interaction
is_a: GO:0052551 ! response to defense-related nitric oxide production by other organism during symbiotic interaction

[Term]
id: GO:0052377
name: evasion or tolerance by organism of symbiont-produced phytoalexins
namespace: biological_process
def: "OBSOLETE. The process by which an organism avoids the effects of phytoalexins produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "evasion or tolerance by organism of symbiont phytoalexins" EXACT []
synonym: "evasion or tolerance of phytoalexins produced by symbiont in response to organism" EXACT []
synonym: "symbiont phytoalexin detoxification" NARROW []
is_obsolete: true

[Term]
id: GO:0052378
name: evasion or tolerance by organism of phytoalexins produced by other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism avoids the effects of phytoalexins produced as a defense response by the second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "evasion or tolerance of other organism phytoalexins" EXACT []
synonym: "evasion or tolerance of phytoalexins produced by other organism" EXACT []
synonym: "phytoalexin detoxification" NARROW []
is_a: GO:0051805 ! evasion or tolerance of immune response of other organism during symbiotic interaction
is_a: GO:0052549 ! response to phytoalexin production by other organism during symbiotic interaction

[Term]
id: GO:0052379
name: modulation by organism of entry into other organism via phagocytosis during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent to which it enters into a second organism via the phagocytotic processes of the other organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of entry into other organism via other organism phagocytosis during symbiotic interaction" EXACT []
is_a: GO:0052371 ! regulation by organism of entry into other organism during symbiotic interaction

[Term]
id: GO:0052380
name: modulation by symbiont of entry into host via phagocytosis
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent to which it enters into the host, via the phagocytotic processes of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation by organism of entry into host via host phagocytosis" EXACT []
is_a: GO:0052372 ! modulation by symbiont of entry into host
is_a: GO:0052379 ! modulation by organism of entry into other organism via phagocytosis during symbiotic interaction

[Term]
id: GO:0052382
name: induction by organism of innate immunity in other organism during symbiotic interaction
namespace: biological_process
def: "The activation by an organism of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of innate immune response in other organism during symbiotic interaction" EXACT []
synonym: "activation by organism of innate immunity in other organism during symbiotic interaction" EXACT []
synonym: "induction by organism of innate immune response in other organism during symbiotic interaction" EXACT []
is_a: GO:0052251 ! induction by organism of defense response of other organism during symbiotic interaction
is_a: GO:0052305 ! positive regulation by organism of innate immunity in other organism during symbiotic interaction
is_a: GO:0052558 ! induction by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052383
name: induction by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont innate immune response" EXACT []
synonym: "activation by organism of symbiont innate immunity" EXACT []
synonym: "induction by organism of symbiont innate immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052384
name: evasion or tolerance by organism of symbiont-produced reactive oxygen species
namespace: biological_process
def: "OBSOLETE. The process by which an organism avoids the effects of reactive oxygen species produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "evasion by organism of cellular damage caused by symbiont oxidative burst" NARROW []
synonym: "evasion or tolerance by organism of reactive oxygen species produced during symbiont defense response" EXACT []
synonym: "evasion or tolerance of defense-related symbiont metabolic burst" EXACT []
synonym: "evasion or tolerance of defense-related symbiont oxidative burst" EXACT []
synonym: "evasion or tolerance of defense-related symbiont respiratory burst" EXACT []
synonym: "evasion or tolerance of reactive oxygen species produced by symbiont in response to organism" EXACT []
synonym: "evasion or tolerance of symbiont-produced active oxygen species" EXACT []
synonym: "evasion or tolerance of symbiont-produced AOS" EXACT []
synonym: "evasion or tolerance of symbiont-produced reactive oxygen intermediates" EXACT []
synonym: "evasion or tolerance of symbiont-produced ROIs" EXACT []
synonym: "evasion or tolerance of symbiont-produced ROS" EXACT []
is_obsolete: true

[Term]
id: GO:0052385
name: evasion or tolerance by organism of reactive oxygen species produced by other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism avoids the effects of reactive oxygen species produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "evasion by organism of cellular damage caused by oxidative burst of other organism" NARROW []
synonym: "evasion or tolerance by organism of defense-related metabolic burst in other organism during symbiotic interaction" EXACT []
synonym: "evasion or tolerance by organism of defense-related oxidative burst in other organism during symbiotic interaction" EXACT []
synonym: "evasion or tolerance by organism of defense-related respiratory burst in other organism during symbiotic interaction" EXACT []
synonym: "evasion or tolerance by organism of reactive oxygen species produced during defense response of other organism" EXACT []
synonym: "evasion or tolerance of active oxygen species produced by other organism" EXACT []
synonym: "evasion or tolerance of AOS produced by other organism" EXACT []
synonym: "evasion or tolerance of reactive oxygen intermediates produced by other organism" EXACT []
synonym: "evasion or tolerance of reactive oxygen species produced by other organism" EXACT []
synonym: "evasion or tolerance of ROIs produced by other organism" EXACT []
synonym: "evasion or tolerance of ROS produced by other organism" EXACT []
is_a: GO:0051805 ! evasion or tolerance of immune response of other organism during symbiotic interaction
is_a: GO:0052550 ! response to defense-related reactive oxygen species production by other organism during symbiotic interaction

[Term]
id: GO:0052386
name: cell wall thickening
namespace: biological_process
def: "A type of cell wall modification in which the cell wall is reinforced and made thicker." [GOC:mtg_pamgo_17jul06]
is_a: GO:0042545 ! cell wall modification

[Term]
id: GO:0052387
name: induction by organism of symbiont apoptosis
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont apoptosis" EXACT []
synonym: "activation by organism of symbiont apoptotic programmed cell death" EXACT []
synonym: "induction by organism of symbiont apoptotic programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052388
name: induction by organism of apoptosis in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of apoptosis in other organism during symbiotic interaction" EXACT []
synonym: "activation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" EXACT []
synonym: "induction by organism of apoptotic programmed cell death in other organism during symbiotic interaction" EXACT []
is_a: GO:0052400 ! induction by organism of programmed cell death in other organism during symbiotic interaction
is_a: GO:0052501 ! positive regulation by organism of apoptosis in other organism during symbiotic interaction

[Term]
id: GO:0052389
name: positive regulation by symbiont of defense-related host calcium ion flux
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of defense-related host calcium ion flux" NARROW []
synonym: "positive regulation by organism of defense-related host Ca2+ flux" EXACT []
synonym: "stimulation by symbiont of defense-related host calcium ion flux" NARROW []
synonym: "up regulation by symbiont of defense-related host calcium ion flux" EXACT []
synonym: "up-regulation by symbiont of defense-related host calcium ion flux" EXACT []
synonym: "upregulation by symbiont of defense-related host calcium ion flux" EXACT []
is_a: GO:0052065 ! positive regulation by organism of defense-related calcium ion flux in other organism during symbiotic interaction
is_a: GO:0052162 ! modulation by symbiont of defense-related host calcium ion flux
is_a: GO:0052509 ! positive regulation by symbiont of host defense response

[Term]
id: GO:0052390
name: induction by symbiont of host innate immunity
namespace: biological_process
def: "The activation by an organism of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of host innate immune response" EXACT []
synonym: "activation by organism of host innate immunity" EXACT []
synonym: "induction by organism of host innate immune response" RELATED []
is_a: GO:0052166 ! positive regulation by symbiont of host innate immunity
is_a: GO:0052382 ! induction by organism of innate immunity in other organism during symbiotic interaction
is_a: GO:0052559 ! induction by symbiont of host immune response

[Term]
id: GO:0052391
name: induction by symbiont of defense-related host calcium ion flux
namespace: biological_process
def: "The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of host Ca2+ flux" EXACT []
synonym: "activation by organism of host calcium ion flux" EXACT []
synonym: "induction by organism of host Ca2+ flux" EXACT []
is_a: GO:0044416 ! induction by symbiont of host defense response
is_a: GO:0052265 ! induction by organism of defense-related calcium ion flux in other organism during symbiotic interaction
is_a: GO:0052389 ! positive regulation by symbiont of defense-related host calcium ion flux

[Term]
id: GO:0052392
name: induction by organism of defense-related symbiont calcium ion flux
namespace: biological_process
def: "OBSOLETE. The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont Ca2+ flux" EXACT []
synonym: "activation by organism of symbiont calcium ion flux" EXACT []
synonym: "induction by organism of symbiont Ca2+ flux" EXACT []
is_obsolete: true

[Term]
id: GO:0052393
name: induction by host of symbiont defense response
namespace: biological_process
def: "The activation by an organism of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc]
synonym: "activation of symbiont defense response" EXACT []
is_a: GO:0052197 ! positive regulation by host of symbiont defense response
is_a: GO:0052251 ! induction by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052394
name: induction by organism of defense-related symbiont cell wall thickening
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont defense-related cell wall thickening" EXACT []
synonym: "activation by organism of symbiont defensive cell wall thickening" EXACT []
synonym: "induction by organism of symbiont defensive cell wall thickening" EXACT []
is_obsolete: true

[Term]
id: GO:0052395
name: induction by organism of defense-related symbiont nitric oxide production
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense-related symbiont nitric acid production" EXACT []
synonym: "activation by organism of defense-related symbiont NO production" EXACT []
synonym: "induction by organism of defense-related symbiont NO production" EXACT []
is_obsolete: true

[Term]
id: GO:0052396
name: induction by organism of symbiont non-apoptotic programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont non-apoptotic programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052398
name: induction by organism of symbiont phytoalexin production
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont phytoalexin production" EXACT []
is_obsolete: true

[Term]
id: GO:0052399
name: induction by organism of symbiont programmed cell death
namespace: biological_process
def: "OBSOLETE. The activation by an organism of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052400
name: induction by organism of programmed cell death in other organism during symbiotic interaction
namespace: biological_process
alt_id: GO:0012504
alt_id: GO:0052397
def: "The activation by an organism of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of non-apoptotic programmed cell death in other organism" NARROW []
synonym: "activation by organism of programmed cell death in other organism during symbiotic interaction" EXACT []
synonym: "induction by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW []
synonym: "induction of non-apoptotic programmed cell death by other organism" RELATED []
is_a: GO:0012502 ! induction of programmed cell death
is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death

[Term]
id: GO:0052401
name: induction by organism of defense-related symbiont reactive oxygen species production
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense-related symbiont active oxygen species production" EXACT []
synonym: "activation by organism of defense-related symbiont AOS production" EXACT []
synonym: "activation by organism of defense-related symbiont metabolic burst" EXACT []
synonym: "activation by organism of defense-related symbiont oxidative burst" EXACT []
synonym: "activation by organism of defense-related symbiont reactive oxidative species production" EXACT []
synonym: "activation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT []
synonym: "activation by organism of defense-related symbiont reactive oxygen species production" EXACT []
synonym: "activation by organism of defense-related symbiont respiratory burst" EXACT []
synonym: "activation by organism of defense-related symbiont ROI production" EXACT []
synonym: "activation by organism of defense-related symbiont ROS production" EXACT []
synonym: "induction by organism of defense-related symbiont active oxygen species production" EXACT []
synonym: "induction by organism of defense-related symbiont AOS production" EXACT []
synonym: "induction by organism of defense-related symbiont metabolic burst" EXACT []
synonym: "induction by organism of defense-related symbiont oxidative burst" EXACT []
synonym: "induction by organism of defense-related symbiont reactive oxygen intermediate production" EXACT []
synonym: "induction by organism of defense-related symbiont respiratory burst" EXACT []
synonym: "induction by organism of defense-related symbiont ROI production" EXACT []
synonym: "induction by organism of defense-related symbiont ROS production" EXACT []
is_obsolete: true

[Term]
id: GO:0052402
name: induction by organism of symbiont resistance gene-dependent defense response
namespace: biological_process
def: "OBSOLETE. The activation by an organism of the resistance gene-dependent defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense response in symbiont by specific elicitors" EXACT []
synonym: "activation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT []
synonym: "activation by organism of symbiont gene-for-gene resistance" EXACT []
synonym: "activation by organism of symbiont resistance gene-dependent defense response" EXACT []
synonym: "induction by organism of defense response in symbiont by specific elicitors" EXACT []
synonym: "induction by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT []
synonym: "induction by organism of symbiont gene-for-gene resistance" EXACT []
is_obsolete: true

[Term]
id: GO:0052403
name: negative regulation by host of symbiont catalytic activity
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by host of symbiont enzyme activity" EXACT []
synonym: "down-regulation by host of symbiont enzyme activity" EXACT []
synonym: "downregulation by host of symbiont enzyme activity" EXACT []
synonym: "inhibition by host of symbiont enzyme activity" NARROW []
synonym: "inhibition of symbiont enzyme activity" EXACT []
synonym: "negative regulation by host of symbiont enzyme activity" EXACT []
is_a: GO:0052199 ! negative regulation of catalytic activity in other organism during symbiotic interaction
is_a: GO:0052405 ! negative regulation by host of symbiont molecular function
is_a: GO:0052422 ! modulation by host of symbiont catalytic activity

[Term]
id: GO:0052404
name: negative regulation by host of symbiont peptidase activity
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
synonym: "down regulation by host of symbiont protease activity" EXACT []
synonym: "down-regulation by host of symbiont protease activity" EXACT []
synonym: "downregulation by host of symbiont protease activity" EXACT []
synonym: "inhibition by host of symbiont protease activity" NARROW []
synonym: "inhibition of symbiont protease activity" EXACT []
synonym: "negative regulation by host of symbiont protease activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0052180 ! negative regulation of peptidase activity in other organism during symbiotic interaction
is_a: GO:0052403 ! negative regulation by host of symbiont catalytic activity
is_a: GO:0052427 ! modulation by host of symbiont protease activity

[Term]
id: GO:0052405
name: negative regulation by host of symbiont molecular function
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the functional activity of symbiont proteins. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
synonym: "down regulation by host of symbiont protein function" EXACT []
synonym: "down-regulation by host of symbiont protein function" EXACT []
synonym: "downregulation by host of symbiont protein function" EXACT []
synonym: "inhibition by host of symbiont protein function" NARROW []
synonym: "inhibition of symbiont protein function" EXACT []
synonym: "negative regulation by host of symbiont protein function" EXACT [GOC:dph, GOC:tb]
is_a: GO:0052204 ! negative regulation of molecular function in other organism during symbiotic interaction
is_a: GO:0052428 ! modification by host of symbiont molecular function

[Term]
id: GO:0052406
name: metabolism by host of symbiont carbohydrate
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving carbohydrates within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism during symbiotic interaction
is_a: GO:0052416 ! metabolism by host of symbiont macromolecule

[Term]
id: GO:0052407
name: metabolism by organism of carbohydrate in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving carbohydrates within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0044040 ! multi-organism carbohydrate metabolic process
is_a: GO:0052229 ! metabolism of macromolecule in other organism during symbiotic interaction

[Term]
id: GO:0052408
name: metabolism by host of symbiont cell wall cellulose
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate
is_a: GO:0052409 ! metabolism by organism of cell wall cellulose in other organism during symbiotic interaction

[Term]
id: GO:0052409
name: metabolism by organism of cell wall cellulose in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0044037 ! multi-organism cell wall macromolecule metabolic process
is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism during symbiotic interaction
is_a: GO:0052541 ! plant-type cell wall cellulose metabolic process

[Term]
id: GO:0052410
name: metabolism by host of symbiont cell wall chitin
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate
is_a: GO:0052411 ! metabolism by organism of cell wall chitin in other organism during symbiotic interaction

[Term]
id: GO:0052411
name: metabolism by organism of cell wall chitin in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0006037 ! cell wall chitin metabolic process
is_a: GO:0044037 ! multi-organism cell wall macromolecule metabolic process
is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism during symbiotic interaction

[Term]
id: GO:0052412
name: metabolism by host of symbiont cell wall pectin
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate
is_a: GO:0052413 ! metabolism by organism of cell wall pectin in other organism during symbiotic interaction

[Term]
id: GO:0052413
name: metabolism by organism of cell wall pectin in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving pectin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0044037 ! multi-organism cell wall macromolecule metabolic process
is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism during symbiotic interaction
is_a: GO:0052546 ! cell wall pectin metabolic process

[Term]
id: GO:0052414
name: metabolism by host of symbiont glucan
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving glucans within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate
is_a: GO:0052415 ! metabolism by organism of glucan in other organism during symbiotic interaction

[Term]
id: GO:0052415
name: metabolism by organism of glucan in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving glucans within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0044043 ! multi-organism glucan metabolic process
is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism during symbiotic interaction

[Term]
id: GO:0052416
name: metabolism by host of symbiont macromolecule
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052229 ! metabolism of macromolecule in other organism during symbiotic interaction
is_a: GO:0052419 ! metabolism by host of substance in symbiont

[Term]
id: GO:0052417
name: metabolism by host of symbiont protein
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052416 ! metabolism by host of symbiont macromolecule
is_a: GO:0052418 ! metabolism by organism of protein in other organism during symbiotic interaction

[Term]
id: GO:0052418
name: metabolism by organism of protein in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving protein macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0019538 ! protein metabolic process
is_a: GO:0052229 ! metabolism of macromolecule in other organism during symbiotic interaction

[Term]
id: GO:0052419
name: metabolism by host of substance in symbiont
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052214 ! metabolism of substance in other organism during symbiotic interaction

[Term]
id: GO:0052420
name: metabolism by host of symbiont xylan
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052406 ! metabolism by host of symbiont carbohydrate
is_a: GO:0052421 ! metabolism by organism of xylan in other organism during symbiotic interaction

[Term]
id: GO:0052421
name: metabolism by organism of xylan in other organism during symbiotic interaction
namespace: biological_process
def: "The chemical reactions and pathways performed by an organism involving xylan within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0045491 ! xylan metabolic process
is_a: GO:0052407 ! metabolism by organism of carbohydrate in other organism during symbiotic interaction

[Term]
id: GO:0052422
name: modulation by host of symbiont catalytic activity
namespace: biological_process
def: "The process by which an organism effects a change in symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb]
synonym: "modulation by host of symbiont enzyme activity" EXACT [GOC:tb]
is_a: GO:0052203 ! modulation of catalytic activity in other organism during symbiotic interaction
is_a: GO:0052428 ! modification by host of symbiont molecular function

[Term]
id: GO:0052423
name: positive regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of defense response in other organism by specific elicitors" EXACT []
synonym: "positive regulation by organism of gene-for-gene resistance in other organism" EXACT []
synonym: "stimulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction" EXACT []
is_a: GO:0052297 ! modulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction
is_a: GO:0052555 ! positive regulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052424
name: modification by organism of symbiont morphology or physiology via protein secreted by type III secretion system
namespace: biological_process
def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type III secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052425
name: modification by organism of symbiont morphology or physiology via protein secreted by type II secretion system
namespace: biological_process
def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type II secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052426
name: modification by organism of symbiont morphology or physiology via substance secreted by type IV secretion system
namespace: biological_process
def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type IV secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052427
name: modulation by host of symbiont protease activity
namespace: biological_process
def: "The process by which an organism effects a change in symbiont protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052198 ! modulation of protease activity in other organism during symbiotic interaction
is_a: GO:0052422 ! modulation by host of symbiont catalytic activity

[Term]
id: GO:0052428
name: modification by host of symbiont molecular function
namespace: biological_process
def: "The process by which an organism effects a change in the function of proteins in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb]
synonym: "modification by host of symbiont protein function" EXACT [GOC:dph, GOC:tb]
is_a: GO:0052182 ! modification by host of symbiont morphology or physiology via secreted substance
is_a: GO:0052205 ! modulation of molecular function in other organism during symbiotic interaction

[Term]
id: GO:0052429
name: modulation by organism of symbiont B-cell mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "regulation by organism of symbiont B-cell mediated immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052430
name: modulation by host of symbiont RNA levels
namespace: biological_process
def: "The alteration by an organism of the levels of RNA in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052249 ! modulation of RNA levels in other organism during symbiotic interaction

[Term]
id: GO:0052431
name: modulation by organism of symbiont T-cell mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of a symbiont organism, where the two organisms are in a symbiotic interaction. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052432
name: modulation by organism of symbiont apoptosis
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont apoptotic programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052433
name: modulation by organism of apoptosis in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" EXACT []
is_a: GO:0042981 ! regulation of apoptosis
is_a: GO:0052248 ! modulation of programmed cell death in other organism during symbiotic interaction

[Term]
id: GO:0052434
name: modulation by organism of symbiont cell-mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of any form of cell-based immune response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont cell-based immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052435
name: modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "modulation of defense-related symbiont MAPK-mediated signal transduction pathway by organism" EXACT []
synonym: "modulation of defense-related symbiont mitogen activated protein kinase-mediated signal transduction pathway by organism" EXACT []
is_a: GO:0052277 ! modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction
is_a: GO:0075099 ! modulation by host of symbiont protein kinase-mediated signal transduction

[Term]
id: GO:0052436
name: modulation by organism of defense-related symbiont calcium-dependent protein kinase pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the symbiont calcium-dependent protein kinase signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont CDPK pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052437
name: modulation by organism of defense-related symbiont calcium ion flux
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont Ca2+ flux" EXACT []
is_obsolete: true

[Term]
id: GO:0052438
name: modulation by organism of defense-related symbiont callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of callose deposition by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052439
name: modulation by organism of defense-related symbiont cell wall callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052440
name: modulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052441
name: modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of ethylene-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052250 ! modulation of signal transduction pathway in other organism during symbiotic interaction
is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052442
name: modulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation of defense-related symbiont JA-mediated signal transduction pathway by organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052443
name: modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of jasmonic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of defense-related JA-mediated signal transduction pathway in other organism" EXACT []
is_a: GO:0052250 ! modulation of signal transduction pathway in other organism during symbiotic interaction
is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052444
name: modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation of defense-related symbiont SA-mediated signal transduction pathway by organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052445
name: modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of salicylic acid-mediated signal transduction pathways that occur as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "modulation of defense-related SA-mediated signal transduction pathway in other organism" EXACT []
is_a: GO:0052250 ! modulation of signal transduction pathway in other organism during symbiotic interaction
is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052446
name: modulation by organism of defense-related symbiont cell wall thickening
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont defensive cell wall thickening" RELATED []
is_obsolete: true

[Term]
id: GO:0052447
name: modulation by organism of symbiont ethylene-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052448
name: modulation by organism of ethylene levels in symbiont
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of ethylene in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052449
name: modulation by organism of ethylene levels in other organism during symbiotic interaction
namespace: biological_process
def: "The alteration by an organism of the levels of ethylene in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction

[Term]
id: GO:0052450
name: modulation by organism of induced systemic resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of induced systemic resistance in the symbiont organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052451
name: modulation by organism of symbiont inflammatory response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052452
name: modulation by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation of symbiont innate immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052453
name: modulation by organism of symbiont intracellular transport
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation of symbiont intracellular trafficking" EXACT []
is_obsolete: true

[Term]
id: GO:0052454
name: modulation by organism of symbiont jasmonic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont JA-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052455
name: modulation by organism of jasmonic acid levels in symbiont
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of jasmonic acid in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052456
name: modulation by organism of jasmonic acid levels in other organism during symbiotic interaction
namespace: biological_process
def: "The alteration by an organism of the levels of jasmonic acid in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction

[Term]
id: GO:0052457
name: modulation by organism of defense-related symbiont nitric oxide production
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont NO production" EXACT []
is_obsolete: true

[Term]
id: GO:0052458
name: modulation by organism of symbiont non-apoptotic programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052460
name: modulation by host of nutrient release from symbiont
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052313 ! modulation of nutrient release from other organism during symbiotic interaction
relationship: part_of GO:0051850 ! acquisition of nutrients from symbiont

[Term]
id: GO:0052461
name: modulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052462
name: modulation by host of symbiont phagocytosis
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052231 ! modulation of phagocytosis in other organism during symbiotic interaction

[Term]
id: GO:0052463
name: modulation by organism of symbiont phytoalexin production
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052464
name: modulation by organism of symbiont programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation of symbiont HR" BROAD []
synonym: "modulation of symbiont hypersensitive response" NARROW []
synonym: "modulation of symbiont PCD" EXACT []
is_obsolete: true

[Term]
id: GO:0052465
name: modulation by organism of defense-related symbiont reactive oxygen species production
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense-related symbiont active oxygen species production" EXACT []
synonym: "modulation by organism of defense-related symbiont AOS production" EXACT []
synonym: "modulation by organism of defense-related symbiont metabolic burst" EXACT []
synonym: "modulation by organism of defense-related symbiont oxidative burst" EXACT []
synonym: "modulation by organism of defense-related symbiont reactive oxidative species production" EXACT []
synonym: "modulation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT []
synonym: "modulation by organism of defense-related symbiont respiratory burst" EXACT []
synonym: "modulation by organism of defense-related symbiont ROI production" EXACT []
synonym: "modulation by organism of defense-related symbiont ROS production" EXACT []
is_obsolete: true

[Term]
id: GO:0052466
name: modulation by organism of symbiont resistance gene-dependent defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of defense response in symbiont by specific elicitors" EXACT []
synonym: "modulation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT []
synonym: "modulation by organism of symbiont gene-for-gene resistance" EXACT []
is_obsolete: true

[Term]
id: GO:0052467
name: modulation by organism of symbiont salicylic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "modulation by organism of symbiont SA-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052468
name: modulation by organism of salicylic acid levels in symbiont
namespace: biological_process
def: "OBSOLETE. The alteration by an organism of the levels of salicylic acid in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052469
name: modulation by organism of salicylic acid levels in other organism during symbiotic interaction
namespace: biological_process
def: "The alteration by an organism of the levels of salicylic acid in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction

[Term]
id: GO:0052470
name: modulation by host of symbiont signal transduction pathway
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052250 ! modulation of signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052471
name: modulation by organism of systemic acquired resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052472
name: modulation by host of symbiont transcription
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of symbiont transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0051851 ! modification by host of symbiont morphology or physiology
is_a: GO:0052312 ! modulation of transcription in other organism during symbiotic interaction

[Term]
id: GO:0052473
name: negative regulation by organism of symbiont B-cell mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the B-cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052474
name: negative regulation by organism of symbiont T-cell mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the T-cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052475
name: negative regulation by organism of symbiont cell-mediated immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of symbiont cell-based immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052476
name: negative regulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature.
synonym: "negative regulation by organism of defense-related symbiont MAPK-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related symbiont mitogen-activated protein kinase-mediated signal transduction pathway" EXACT []
synonym: "suppression by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052477
name: negative regulation by organism of defense-related symbiont callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of callose deposition performed by the symbiont as part of its defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "suppression by organism of defense-related symbiont callose deposition" EXACT []
is_obsolete: true

[Term]
id: GO:0052478
name: negative regulation by organism of defense-related symbiont cell wall callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature.
is_obsolete: true

[Term]
id: GO:0052479
name: negative regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "suppression by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052480
name: negative regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation by organism of defense-related symbiont JA-mediated signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052481
name: negative regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative modulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT []
synonym: "negative modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT []
synonym: "negative regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT []
is_obsolete: true

[Term]
id: GO:0052482
name: cell wall thickening during defense response
namespace: biological_process
def: "A type of cell wall modification, in which the cell wall is reinforced and made thicker, that occurs as part of the defense response of an organism." [GOC:mtg_pamgo_17jul06]
is_a: GO:0006952 ! defense response
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0052386 ! cell wall thickening

[Term]
id: GO:0052483
name: negative regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops or prevents itself undergoing phagocytosis into a cell in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" EXACT []
synonym: "downregulation by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" EXACT []
synonym: "inhibition by organism of entry into cell of other organism via phagocytosis during symbiotic interaction" NARROW []
synonym: "negative regulation by organism of entry into cell of other organism via other organism phagocytosis during symbiotic interaction" EXACT []
is_a: GO:0051834 ! evasion or tolerance of defenses of other organism during symbiotic interaction
is_a: GO:0052373 ! negative regulation by organism of entry into other organism during symbiotic interaction
is_a: GO:0052379 ! modulation by organism of entry into other organism via phagocytosis during symbiotic interaction

[Term]
id: GO:0052484
name: negative regulation by organism of symbiont ethylene-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "suppression by organism of symbiont ethylene-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052485
name: negative regulation by organism of symbiont inflammatory response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052486
name: negative regulation by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the innate immune response of the symbiont organism, the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation of symbiont innate immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052487
name: negative regulation by organism of symbiont jasmonic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "suppression by organism of symbiont JA-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052488
name: negative regulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "suppression of general elicitor induced symbiont innate immunity" EXACT []
synonym: "suppression of general elicitor-induced symbiont innate immunity" EXACT []
synonym: "suppression of MAMP induced symbiont innate immunity" EXACT []
synonym: "suppression of MAMP-induced symbiont innate immunity" EXACT []
synonym: "suppression of PAMP induced symbiont innate immunity" EXACT []
synonym: "suppression of PAMP-induced symbiont innate immunity" EXACT []
synonym: "suppression of pathogen-associated molecular pattern-induced symbiont innate immunity" EXACT []
is_obsolete: true

[Term]
id: GO:0052489
name: negative regulation by host of symbiont programmed cell death
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by host of symbiont programmed cell death" EXACT []
synonym: "down-regulation by host of symbiont programmed cell death" EXACT []
synonym: "downregulation by host of symbiont programmed cell death" EXACT []
synonym: "inhibition by host of symbiont programmed cell death" NARROW []
synonym: "inhibition of symbiont programmed cell death" EXACT []
is_a: GO:0052490 ! negative regulation by organism of programmed cell death in other organism during symbiotic interaction

[Term]
id: GO:0052490
name: negative regulation by organism of programmed cell death in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of programmed cell death in other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of programmed cell death in other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of programmed cell death in other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of programmed cell death in other organism during symbiotic interaction" NARROW []
synonym: "inhibition of programmed cell death in other organism" EXACT []
is_a: GO:0043069 ! negative regulation of programmed cell death
is_a: GO:0052248 ! modulation of programmed cell death in other organism during symbiotic interaction

[Term]
id: GO:0052491
name: negative regulation by organism of symbiont salicylic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "negative regulation of symbiont SA-mediated defense response" EXACT []
synonym: "suppression by organism of symbiont salicylic acid-mediated defense response" EXACT []
synonym: "suppression of symbiont SA mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052492
name: negative regulation by host of symbiont signal transduction pathway
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "down regulation by host of symbiont signal transduction pathway" EXACT []
synonym: "down-regulation by host of symbiont signal transduction pathway" EXACT []
synonym: "downregulation by host of symbiont signal transduction pathway" EXACT []
synonym: "inhibition by host of symbiont signal transduction pathway" NARROW []
synonym: "negative modulation by organism of symbiont signal transduction pathway" EXACT []
is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway
is_a: GO:0052493 ! negative regulation by organism of signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052493
name: negative regulation by organism of signal transduction pathway in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the second organism signal transduction pathways, the cascade of processes by which a signal interacts with a receptor, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "negative modulation by organism of other organism signal transduction pathway" EXACT []
is_a: GO:0052250 ! modulation of signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052494
name: occlusion by host of symbiont vascular system
namespace: biological_process
def: "The process by which an organism reduces the flow of fluid within its symbiont's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com]
subset: gosubset_prok
is_a: GO:0052183 ! modification by host of symbiont structure
is_a: GO:0052495 ! occlusion by organism of vascular system in other organism during symbiotic interaction

[Term]
id: GO:0052495
name: occlusion by organism of vascular system in other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism reduces the flow of fluid within its second organism's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com]
subset: gosubset_prok
is_a: GO:0052185 ! modification of structure of other organism during symbiotic interaction

[Term]
id: GO:0052496
name: occlusion by host of symbiont xylem
namespace: biological_process
def: "The process by which an organism reduces the flow of fluid within the symbiont xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052494 ! occlusion by host of symbiont vascular system
is_a: GO:0052497 ! occlusion by organism of xylem in other organism during symbiotic interaction

[Term]
id: GO:0052497
name: occlusion by organism of xylem in other organism during symbiotic interaction
namespace: biological_process
def: "The process by which an organism reduces the flow of fluid within the xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052495 ! occlusion by organism of vascular system in other organism during symbiotic interaction

[Term]
id: GO:0052498
name: pathogen-associated molecular pattern dependent induction by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "general elicitor-dependent activation of symbiont innate immunity" EXACT []
synonym: "general elicitor-dependent induction of symbiont innate immunity" EXACT []
synonym: "MAMP dependent activation of symbiont innate immunity" EXACT []
synonym: "MAMP dependent induction of symbiont innate immunity" EXACT []
synonym: "PAMP dependent activation of symbiont innate immunity" EXACT []
synonym: "PAMP dependent induction of symbiont innate immunity" EXACT []
synonym: "pathogen-associated molecular pattern dependent activation by organism of symbiont innate immunity" EXACT []
is_obsolete: true

[Term]
id: GO:0052499
name: pathogen-associated molecular pattern dependent modulation by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052500
name: positive regulation by organism of symbiont apoptosis
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of symbiont apoptotic programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052501
name: positive regulation by organism of apoptosis in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of apoptosis in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" EXACT []
synonym: "stimulation by organism of apoptosis in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of apoptosis in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of apoptosis in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of apoptosis in other organism during symbiotic interaction" EXACT []
is_a: GO:0043065 ! positive regulation of apoptosis
is_a: GO:0052330 ! positive regulation by organism of programmed cell death in other organism during symbiotic interaction
is_a: GO:0052433 ! modulation by organism of apoptosis in other organism during symbiotic interaction

[Term]
id: GO:0052502
name: positive regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "activation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related symbiont MAPK-mediated signal transduction pathway" EXACT []
synonym: "positive regulation by organism of defense-related symbiont mitogen-activated protein kinase-mediated signal transduction pathway" EXACT []
synonym: "stimulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW []
synonym: "up regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "up-regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "upregulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW []
is_a: GO:0052276 ! positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism during symbiotic interaction
is_a: GO:0052435 ! modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway
is_a: GO:0075100 ! positive regulation by host of symbiont protein kinase-mediated signal transduction

[Term]
id: GO:0052503
name: positive regulation by organism of defense-related symbiont calcium-dependent protein kinase pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the symbiont calcium-dependent protein kinase pathway during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation of defense-related symbiont CDPK pathway by organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052504
name: positive regulation by organism of defense-related symbiont callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of callose deposition by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "induction by organism of defense-related papilla formation in symbiont" NARROW []
synonym: "induction by organism of defense-related symbiont callose deposition" NARROW []
synonym: "positive regulation by organism of defense-related papilla formation in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052505
name: positive regulation by organism of defense-related symbiont cell wall callose deposition
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "induction by organism of defense-related symbiont cell wall callose deposition" NARROW []
is_obsolete: true

[Term]
id: GO:0052506
name: positive regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW []
synonym: "upregulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW []
is_obsolete: true

[Term]
id: GO:0052507
name: positive regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "activation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT []
synonym: "upregulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW []
synonym: "upregulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
is_obsolete: true

[Term]
id: GO:0052508
name: positive regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "activation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "induction by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW []
synonym: "positive regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "upregulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW []
synonym: "upregulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW []
is_obsolete: true

[Term]
id: GO:0052509
name: positive regulation by symbiont of host defense response
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host defense response" NARROW []
synonym: "stimulation by symbiont of host defense response" NARROW []
synonym: "up regulation by symbiont of host defense response" EXACT []
synonym: "up-regulation by symbiont of host defense response" EXACT []
synonym: "upregulation by symbiont of host defense response" EXACT []
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052510
name: positive regulation by organism of defense response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense response of other organism during symbiotic interaction" NARROW []
synonym: "stimulation by organism of defense response of other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense response of other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of defense response of other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of defense response of other organism during symbiotic interaction" EXACT []
is_a: GO:0031349 ! positive regulation of defense response
is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052511
name: positive regulation by organism of symbiont ethylene-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "activation by organism of symbiont ethylene-mediated defense response" NARROW []
synonym: "induction by organism of symbiont ethylene-mediated defense response" NARROW []
synonym: "upregulation by organism of symbiont ethylene-mediated defense response" NARROW []
is_obsolete: true

[Term]
id: GO:0052512
name: positive regulation by organism of hormone or growth regulator levels in symbiont
namespace: biological_process
def: "OBSOLETE. The increase by an organism of the levels of hormones or growth regulators in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive modulation of hormone or growth regulator levels in symbiont" EXACT []
is_obsolete: true

[Term]
id: GO:0052513
name: positive regulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction
namespace: biological_process
def: "The increase by an organism of the levels of hormones or growth regulators in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" NARROW []
synonym: "positive modulation of hormone or growth regulator levels in other organism" EXACT []
synonym: "stimulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction" EXACT []
is_a: GO:0052186 ! modulation by organism of hormone or growth regulator levels in other organism during symbiotic interaction

[Term]
id: GO:0052514
name: positive regulation by organism of symbiont inflammatory response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052515
name: positive regulation by organism of symbiont innate immunity
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation of symbiont innate immune response" EXACT []
is_obsolete: true

[Term]
id: GO:0052516
name: positive regulation by organism of symbiont jasmonic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "induction by organism of symbiont JA-mediated defense response" NARROW []
synonym: "induction by organism of symbiont jasmonic acid-mediated defense response" NARROW []
synonym: "positive regulation by organism of symbiont JA-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052517
name: positive regulation by organism of symbiont non-apoptotic programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052519
name: positive regulation by host of nutrient release from symbiont
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by host of nutrient release from symbiont" NARROW []
synonym: "promotion of nutrient release from symbiont" EXACT []
synonym: "stimulation by host of nutrient release from symbiont" NARROW []
synonym: "up regulation by host of nutrient release from symbiont" EXACT []
synonym: "up-regulation by host of nutrient release from symbiont" EXACT []
synonym: "upregulation by host of nutrient release from symbiont" EXACT []
is_a: GO:0052460 ! modulation by host of nutrient release from symbiont
is_a: GO:0052520 ! positive regulation by organism of nutrient release from other organism during symbiotic interaction

[Term]
id: GO:0052520
name: positive regulation by organism of nutrient release from other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of nutrient release from other organism during symbiotic interaction" NARROW []
synonym: "promotion of nutrient release from other organism" EXACT []
synonym: "stimulation by organism of nutrient release from other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of nutrient release from other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of nutrient release from other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of nutrient release from other organism during symbiotic interaction" EXACT []
is_a: GO:0052313 ! modulation of nutrient release from other organism during symbiotic interaction

[Term]
id: GO:0052521
name: positive regulation by host of symbiont phagocytosis
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by host of symbiont phagocytosis" NARROW []
synonym: "stimulation by host of symbiont phagocytosis" NARROW []
synonym: "up regulation by host of symbiont phagocytosis" EXACT []
synonym: "up-regulation by host of symbiont phagocytosis" EXACT []
synonym: "upregulation by host of symbiont phagocytosis" EXACT []
is_a: GO:0052462 ! modulation by host of symbiont phagocytosis
is_a: GO:0052522 ! positive regulation by organism of phagocytosis in other organism during symbiotic interaction

[Term]
id: GO:0052522
name: positive regulation by organism of phagocytosis in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by organism of phagocytosis in other organism during symbiotic interaction" NARROW []
synonym: "stimulation by organism of phagocytosis in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of phagocytosis in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of phagocytosis in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of phagocytosis in other organism during symbiotic interaction" EXACT []
is_a: GO:0050766 ! positive regulation of phagocytosis
is_a: GO:0052231 ! modulation of phagocytosis in other organism during symbiotic interaction

[Term]
id: GO:0052523
name: positive regulation by organism of symbiont programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "enhancement or induction of symbiont programmed cell death" EXACT []
is_obsolete: true

[Term]
id: GO:0052524
name: positive regulation by organism of symbiont salicylic acid-mediated defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "induction by organism of symbiont SA-mediated defense response" NARROW []
synonym: "induction by organism of symbiont salicylic acid-mediated defense response" NARROW []
synonym: "positive regulation by organism of symbiont SA-mediated defense response" EXACT []
is_obsolete: true

[Term]
id: GO:0052525
name: positive regulation by host of symbiont signal transduction pathway
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
synonym: "activation by host of symbiont signal transduction pathway" NARROW []
synonym: "stimulation by host of symbiont signal transduction pathway" NARROW []
synonym: "up regulation by host of symbiont signal transduction pathway" EXACT []
synonym: "up-regulation by host of symbiont signal transduction pathway" EXACT []
synonym: "upregulation by host of symbiont signal transduction pathway" EXACT []
is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway
is_a: GO:0052526 ! positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052526
name: positive regulation by organism of signal transduction pathway in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the second organism signal transduction pathways, the cascade of processes by which a signal interacts with a receptor, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "stimulation by organism of signal transduction pathway in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of signal transduction pathway in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of signal transduction pathway in other organism during symbiotic interaction" EXACT []
is_a: GO:0052250 ! modulation of signal transduction pathway in other organism during symbiotic interaction

[Term]
id: GO:0052527
name: positive regulation by symbiont of host resistance gene-dependent defense response
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host resistance gene-dependent defense response" NARROW []
synonym: "positive regulation by organism of defense response in host by specific elicitors" EXACT []
synonym: "positive regulation by organism of host gene-for-gene resistance" EXACT []
synonym: "positive regulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT []
synonym: "stimulation by symbiont of host resistance gene-dependent defense response" NARROW []
synonym: "up regulation by symbiont of host resistance gene-dependent defense response" EXACT []
synonym: "up-regulation by symbiont of host resistance gene-dependent defense response" EXACT []
synonym: "upregulation by symbiont of host resistance gene-dependent defense response" EXACT []
is_a: GO:0052158 ! modulation by symbiont of host resistance gene-dependent defense response
is_a: GO:0052423 ! positive regulation by organism of resistance gene-dependent defense response of other organism during symbiotic interaction
is_a: GO:0052556 ! positive regulation by symbiont of host immune response

[Term]
id: GO:0052528
name: upregulation by organism of symbiont programmed cell death
namespace: biological_process
def: "OBSOLETE. Any process by which an organism increases the frequency, rate or extent of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "enhancement of symbiont programmed cell death by organism" EXACT []
is_obsolete: true

[Term]
id: GO:0052529
name: upregulation by organism of programmed cell death in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism increases the frequency, rate or extent of programmed cell death in the second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "enhancement of other organism programmed cell death by organism" EXACT []
is_a: GO:0052330 ! positive regulation by organism of programmed cell death in other organism during symbiotic interaction

[Term]
id: GO:0052530
name: positive regulation by organism of symbiont resistance gene-dependent defense response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of defense response in symbiont by specific elicitors" EXACT []
synonym: "positive regulation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT []
synonym: "positive regulation by organism of symbiont gene-for-gene resistance" EXACT []
is_obsolete: true

[Term]
id: GO:0052531
name: positive regulation by organism of defense-related symbiont calcium ion flux
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of defense-related symbiont Ca2+ flux" EXACT []
is_obsolete: true

[Term]
id: GO:0052532
name: positive regulation by organism of induced systemic resistance in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance, a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of induced systemic resistance in other organism during symbiotic interaction" NARROW []
synonym: "stimulation by organism of induced systemic resistance in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of induced systemic resistance in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of induced systemic resistance in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of induced systemic resistance in other organism during symbiotic interaction" EXACT []
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0052298 ! modulation by organism of induced systemic resistance in other organism during symbiotic interaction
is_a: GO:0052305 ! positive regulation by organism of innate immunity in other organism during symbiotic interaction

[Term]
id: GO:0052533
name: positive regulation by symbiont of host induced systemic resistance
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of induced systemic resistance in host" NARROW []
synonym: "positive regulation by symbiont of induced systemic resistance in host" EXACT []
synonym: "stimulation by symbiont of induced systemic resistance in host" NARROW []
synonym: "up regulation by symbiont of induced systemic resistance in host" EXACT []
synonym: "up-regulation by symbiont of induced systemic resistance in host" EXACT []
synonym: "upregulation by symbiont of induced systemic resistance in host" EXACT []
is_a: GO:0052159 ! modulation by symbiont of host induced systemic resistance
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:0052532 ! positive regulation by organism of induced systemic resistance in other organism during symbiotic interaction
is_a: GO:0052556 ! positive regulation by symbiont of host immune response

[Term]
id: GO:0052534
name: positive regulation by organism of induced systemic resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the symbiont organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052535
name: positive regulation by organism of systemic acquired resistance in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of systemic acquired resistance in other organism during symbiotic interaction" NARROW []
synonym: "stimulation by organism of systemic acquired resistance in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of systemic acquired resistance in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of systemic acquired resistance in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of systemic acquired resistance in other organism during symbiotic interaction" EXACT []
is_a: GO:0002833 ! positive regulation of response to biotic stimulus
is_a: GO:0052299 ! modulation by organism of systemic acquired resistance in other organism during symbiotic interaction
is_a: GO:0052305 ! positive regulation by organism of innate immunity in other organism during symbiotic interaction

[Term]
id: GO:0052536
name: positive regulation by organism of systemic acquired resistance in symbiont
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052537
name: positive regulation by symbiont of host systemic acquired resistance
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of systemic acquired resistance in host" NARROW []
synonym: "positive regulation by symbiont of systemic acquired resistance in host" EXACT []
synonym: "stimulation by symbiont of systemic acquired resistance in host" NARROW []
synonym: "up regulation by symbiont of systemic acquired resistance in host" EXACT []
synonym: "up-regulation by symbiont of systemic acquired resistance in host" EXACT []
synonym: "upregulation by symbiont of systemic acquired resistance in host" EXACT []
is_a: GO:0052160 ! modulation by symbiont of host systemic acquired resistance
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:0052535 ! positive regulation by organism of systemic acquired resistance in other organism during symbiotic interaction
is_a: GO:0052556 ! positive regulation by symbiont of host immune response

[Term]
id: GO:0052538
name: positive regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the thickening of cell walls that occurs as part of the defense response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" NARROW []
synonym: "positive regulation by organism of defensive cell wall thickening in other organism during symbiotic interaction" EXACT []
synonym: "stimulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction" EXACT []
is_a: GO:0052300 ! modulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction
is_a: GO:0052510 ! positive regulation by organism of defense response of other organism during symbiotic interaction

[Term]
id: GO:0052539
name: positive regulation by symbiont of defense-related host cell wall thickening
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of a host process resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of defense-related host cell wall thickening" NARROW []
synonym: "positive regulation by organism of host defensive cell wall thickening" EXACT []
synonym: "stimulation by symbiont of defense-related host cell wall thickening" NARROW []
synonym: "up regulation by symbiont of defense-related host cell wall thickening" EXACT []
synonym: "up-regulation by symbiont of defense-related host cell wall thickening" EXACT []
synonym: "upregulation by symbiont of defense-related host cell wall thickening" EXACT []
is_a: GO:0052161 ! modulation by symbiont of defense-related host cell wall thickening
is_a: GO:0052509 ! positive regulation by symbiont of host defense response
is_a: GO:0052538 ! positive regulation by organism of defense-related cell wall thickening in other organism during symbiotic interaction

[Term]
id: GO:0052540
name: positive regulation by organism of defense-related symbiont cell wall thickening
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
synonym: "positive regulation by organism of symbiont defensive cell wall thickening" EXACT []
is_obsolete: true

[Term]
id: GO:0052541
name: plant-type cell wall cellulose metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "cell wall cellulose metabolism" EXACT []
synonym: "cellulose and pectin-containing cell wall cellulose metabolic process" EXACT []
is_a: GO:0010383 ! cell wall polysaccharide metabolic process
is_a: GO:0030243 ! cellulose metabolic process
relationship: part_of GO:0009664 ! plant-type cell wall organization

[Term]
id: GO:0052542
name: callose deposition during defense response
namespace: biological_process
def: "Any process by which callose is transported to, and/or maintained in, a specific location during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06]
synonym: "callose localization during defense response" EXACT []
is_a: GO:0006952 ! defense response
is_a: GO:0052545 ! callose localization

[Term]
id: GO:0052543
name: callose deposition in cell wall
namespace: biological_process
def: "Any process by which callose is transported to, and/or maintained in, the cell wall. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06]
synonym: "callose localization in cell wall" EXACT []
synonym: "cell wall callose deposition" EXACT []
synonym: "cell wall callose localization" EXACT []
is_a: GO:0052386 ! cell wall thickening
is_a: GO:0052545 ! callose localization
is_a: GO:0070727 ! cellular macromolecule localization

[Term]
id: GO:0052544
name: callose deposition in cell wall during defense response
namespace: biological_process
def: "Any process by which callose is transported to, and/or maintained in, the cell wall during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06]
synonym: "callose localization in cell wall during defense response" EXACT []
synonym: "cell wall callose deposition during defense response" EXACT []
synonym: "cell wall callose localization during defense response" EXACT []
is_a: GO:0052482 ! cell wall thickening during defense response
is_a: GO:0052542 ! callose deposition during defense response
is_a: GO:0052543 ! callose deposition in cell wall

[Term]
id: GO:0052545
name: callose localization
namespace: biological_process
def: "Any process by which callose is transported to, and/or maintained in, a specific location. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06, http://www.onelook.com]
is_a: GO:0033037 ! polysaccharide localization

[Term]
id: GO:0052546
name: cell wall pectin metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall." [GOC:ai]
synonym: "cell wall pectin metabolism" EXACT []
synonym: "cellulose and pectin-containing cell wall pectin metabolic process" EXACT []
synonym: "pectin metabolism during cell wall biogenesis" EXACT []
synonym: "plant-type cell wall pectin metabolic process" EXACT []
is_a: GO:0010383 ! cell wall polysaccharide metabolic process
is_a: GO:0045488 ! pectin metabolic process
relationship: part_of GO:0009664 ! plant-type cell wall organization

[Term]
id: GO:0052547
name: regulation of peptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [EC:3.4, GOC:ai]
synonym: "peptidase regulator activity" RELATED []
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0052548
name: regulation of endopeptidase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:ai, GOC:hjd]
synonym: "protease regulator activity" RELATED []
is_a: GO:0052547 ! regulation of peptidase activity

[Term]
id: GO:0052549
name: response to phytoalexin production by other organism during symbiotic interaction
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052564 ! response to immune response of other organism during symbiotic interaction

[Term]
id: GO:0052550
name: response to defense-related reactive oxygen species production by other organism during symbiotic interaction
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052564 ! response to immune response of other organism during symbiotic interaction

[Term]
id: GO:0052551
name: response to defense-related nitric oxide production by other organism during symbiotic interaction
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as a defense response by a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052564 ! response to immune response of other organism during symbiotic interaction

[Term]
id: GO:0052552
name: modulation by organism of immune response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0050776 ! regulation of immune response
is_a: GO:0052255 ! modulation by organism of defense response of other organism during symbiotic interaction
is_a: GO:0052564 ! response to immune response of other organism during symbiotic interaction

[Term]
id: GO:0052553
name: modulation by symbiont of host immune response
namespace: biological_process
def: "Any process by which an organism modulates the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052031 ! modulation by symbiont of host defense response
is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction
is_a: GO:0052572 ! response to host immune response

[Term]
id: GO:0052554
name: modulation by organism of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052555
name: positive regulation by organism of immune response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of immune response of other organism during symbiotic interaction" NARROW []
synonym: "stimulation by organism of immune response of other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of immune response of other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of immune response of other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of immune response of other organism during symbiotic interaction" EXACT []
is_a: GO:0050778 ! positive regulation of immune response
is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052556
name: positive regulation by symbiont of host immune response
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by symbiont of host immune response" NARROW []
synonym: "stimulation by symbiont of host immune response" NARROW []
synonym: "up regulation by symbiont of host immune response" EXACT []
synonym: "up-regulation by symbiont of host immune response" EXACT []
synonym: "upregulation by symbiont of host immune response" EXACT []
is_a: GO:0052553 ! modulation by symbiont of host immune response
is_a: GO:0052555 ! positive regulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052557
name: positive regulation by organism of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052558
name: induction by organism of immune response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism activates the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "activation by organism of immune response of other organism during symbiotic interaction" EXACT []
is_a: GO:0052555 ! positive regulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052559
name: induction by symbiont of host immune response
namespace: biological_process
def: "Any process by which an organism activates the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052556 ! positive regulation by symbiont of host immune response
is_a: GO:0052558 ! induction by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052560
name: induction by organism of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism activates the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052561
name: negative regulation by organism of immune response of other organism during symbiotic interaction
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the immune response of a second organism, where the two organisms are in a symbiotic interaction. The immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by organism of immune response of other organism during symbiotic interaction" EXACT []
synonym: "down-regulation by organism of immune response of other organism during symbiotic interaction" EXACT []
synonym: "downregulation by organism of immune response of other organism during symbiotic interaction" EXACT []
synonym: "inhibition by organism of immune response of other organism during symbiotic interaction" NARROW []
is_a: GO:0050777 ! negative regulation of immune response
is_a: GO:0052552 ! modulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052562
name: negative regulation by symbiont of host immune response
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
synonym: "down regulation by symbiont of host immune response" EXACT []
synonym: "down-regulation by symbiont of host immune response" EXACT []
synonym: "downregulation by symbiont of host immune response" EXACT []
synonym: "inhibition by symbiont of host immune response" NARROW []
is_a: GO:0052553 ! modulation by symbiont of host immune response
is_a: GO:0052561 ! negative regulation by organism of immune response of other organism during symbiotic interaction

[Term]
id: GO:0052563
name: negative regulation by organism of symbiont immune response
namespace: biological_process
def: "OBSOLETE. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052564
name: response to immune response of other organism during symbiotic interaction
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052173 ! response to defenses of other organism during symbiotic interaction

[Term]
id: GO:0052565
name: response to defense-related host nitric oxide production
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052551 ! response to defense-related nitric oxide production by other organism during symbiotic interaction
is_a: GO:0052572 ! response to host immune response

[Term]
id: GO:0052566
name: response to host phytoalexin production
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052549 ! response to phytoalexin production by other organism during symbiotic interaction
is_a: GO:0052572 ! response to host immune response

[Term]
id: GO:0052567
name: response to defense-related host reactive oxygen species production
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
is_a: GO:0052550 ! response to defense-related reactive oxygen species production by other organism during symbiotic interaction
is_a: GO:0052572 ! response to host immune response

[Term]
id: GO:0052568
name: response to symbiont phytoalexin production
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052569
name: response to defense-related symbiont nitric oxide production
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052570
name: response to defense-related symbiont reactive oxygen species production
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052571
name: response to symbiont immune response
namespace: biological_process
def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo]
comment: This term was made obsolete because it does not represent a real biological process.
is_obsolete: true

[Term]
id: GO:0052572
name: response to host immune response
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]
subset: gosubset_prok
is_a: GO:0052200 ! response to host defenses
is_a: GO:0052564 ! response to immune response of other organism during symbiotic interaction

[Term]
id: GO:0055001
name: muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0042692 ! muscle cell differentiation

[Term]
id: GO:0055002
name: striated muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:devbiol]
is_a: GO:0055001 ! muscle cell development
relationship: part_of GO:0051146 ! striated muscle cell differentiation

[Term]
id: GO:0055003
name: cardiac myofibril assembly
namespace: biological_process
def: "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol]
synonym: "cardiac myofibril development" EXACT []
synonym: "cardiac myofibril morphogenesis" EXACT []
synonym: "heart myofibril assembly" RELATED []
is_a: GO:0030239 ! myofibril assembly
relationship: part_of GO:0055013 ! cardiac muscle cell development

[Term]
id: GO:0055004
name: atrial cardiac myofibril development
namespace: biological_process
def: "The process whose specific outcome is the progression of the atrial cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol]
synonym: "atrial heart myofibril development" EXACT []
is_a: GO:0055003 ! cardiac myofibril assembly
relationship: part_of GO:0055014 ! atrial cardiac muscle cell development

[Term]
id: GO:0055005
name: ventricular cardiac myofibril development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ventricular cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol]
synonym: "ventricular heart myofibril development" EXACT []
is_a: GO:0055003 ! cardiac myofibril assembly
relationship: part_of GO:0055015 ! ventricular cardiac muscle cell development

[Term]
id: GO:0055006
name: cardiac cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual." [GOC:devbiol]
synonym: "heart cell development" RELATED []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0035051 ! cardiac cell differentiation

[Term]
id: GO:0055007
name: cardiac muscle cell differentiation
namespace: biological_process
def: "The process whereby a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:devbiol, GOC:mtg_heart]
synonym: "cardiomyocyte differentiation" EXACT []
synonym: "heart muscle cell differentiation" RELATED []
is_a: GO:0035051 ! cardiac cell differentiation
is_a: GO:0051146 ! striated muscle cell differentiation
relationship: part_of GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055008
name: cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of cardiac muscle tissue are generated and organized. Morphogenesis pertains to the creation of form." [GOC:devbiol]
synonym: "heart muscle morphogenesis" EXACT []
synonym: "myocardium morphogenesis" BROAD [GOC:mtg_heart]
is_a: GO:0060415 ! muscle tissue morphogenesis
relationship: part_of GO:0003007 ! heart morphogenesis
relationship: part_of GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055009
name: atrial cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of cardiac atrium muscle is generated and organized. Morphogenesis pertains to the creation of form." [GOC:devbiol]
synonym: "atrial heart muscle morphogenesis" EXACT []
synonym: "atrial myocardium morphogenesis" EXACT [GOC:mtg_heart]
synonym: "cardiac atrium muscle morphogenesis" EXACT []
is_a: GO:0055008 ! cardiac muscle tissue morphogenesis
relationship: part_of GO:0003209 ! cardiac atrium morphogenesis
relationship: part_of GO:0003228 ! atrial cardiac muscle tissue development

[Term]
id: GO:0055010
name: ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of cardiac ventricle muscle is generated and organized. Morphogenesis pertains to the creation of form." [GOC:devbiol]
synonym: "cardiac ventricle muscle morphogenesis" EXACT []
synonym: "ventricular heart muscle morphogenesis" EXACT []
is_a: GO:0055008 ! cardiac muscle tissue morphogenesis
relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis
relationship: part_of GO:0003229 ! ventricular cardiac muscle tissue development

[Term]
id: GO:0055011
name: atrial cardiac muscle cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a cardiac muscle cell in the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ." [GOC:devbiol, GOC:mtg_heart]
synonym: "atrial cardiomyocyte differentiation" EXACT []
synonym: "atrial heart muscle cell differentiation" EXACT []
is_a: GO:0055007 ! cardiac muscle cell differentiation

[Term]
id: GO:0055012
name: ventricular cardiac muscle cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ." [GOC:devbiol, GOC:mtg_heart]
synonym: "ventricular cardiomyocyte differentiation" EXACT []
synonym: "ventricular heart muscle cell differentiation" EXACT []
is_a: GO:0055007 ! cardiac muscle cell differentiation

[Term]
id: GO:0055013
name: cardiac muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state." [GOC:devbiol, GOC:mtg_heart]
synonym: "cardiomyocyte cell development" EXACT [GOC:mtg_muscle]
synonym: "heart muscle cell development" EXACT []
is_a: GO:0055001 ! muscle cell development
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0055007 ! cardiac muscle cell differentiation

[Term]
id: GO:0055014
name: atrial cardiac muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ." [GOC:devbiol]
synonym: "atrial cardiomyocyte development" EXACT []
synonym: "atrial heart muscle development" EXACT []
is_a: GO:0055013 ! cardiac muscle cell development
relationship: part_of GO:0055011 ! atrial cardiac muscle cell differentiation

[Term]
id: GO:0055015
name: ventricular cardiac muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ." [GOC:devbiol, GOC:mtg_muscle]
synonym: "ventricular cardiomyocyte development" EXACT []
synonym: "ventricular heart muscle cell development" EXACT []
is_a: GO:0055013 ! cardiac muscle cell development
relationship: part_of GO:0055012 ! ventricular cardiac muscle cell differentiation

[Term]
id: GO:0055016
name: hypochord development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hypochord over time, from its formation to the mature structure. The hypochord is a transient rod-like structure in the embryos of fish, lampreys and amphibians that is located immediately ventral to the notochord. The hypochord may play a role in positioning the dorsal aorta." [GOC:devbiol, GOC:lb]
synonym: "subnotochordal rod development" EXACT []
is_a: GO:0048568 ! embryonic organ development

[Term]
id: GO:0055017
name: cardiac muscle tissue growth
namespace: biological_process
def: "The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:devbiol]
synonym: "heart muscle growth" EXACT []
is_a: GO:0040007 ! growth
relationship: part_of GO:0048738 ! cardiac muscle tissue development
relationship: part_of GO:0060419 ! heart growth

[Term]
id: GO:0055018
name: regulation of cardiac muscle fiber development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk]
synonym: "regulation of cardiac muscle fibre development" EXACT []
synonym: "regulation of heart muscle fiber development" EXACT []
is_a: GO:0055024 ! regulation of cardiac muscle tissue development
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0048739 ! cardiac muscle fiber development

[Term]
id: GO:0055019
name: negative regulation of cardiac muscle fiber development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk]
synonym: "down regulation of cardiac muscle fiber development" EXACT []
synonym: "down-regulation of cardiac muscle fiber development" EXACT []
synonym: "downregulation of cardiac muscle fiber development" EXACT []
synonym: "inhibition of cardiac muscle fiber development" NARROW []
synonym: "negative regulation of cardiac muscle fibre development" EXACT []
synonym: "negative regulation of heart muscle fiber development" RELATED []
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0055018 ! regulation of cardiac muscle fiber development
relationship: negatively_regulates GO:0048739 ! cardiac muscle fiber development
relationship: part_of GO:0055026 ! negative regulation of cardiac muscle tissue development

[Term]
id: GO:0055020
name: positive regulation of cardiac muscle fiber development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk]
synonym: "activation of cardiac muscle fiber development" NARROW []
synonym: "positive regulation of cardiac muscle fibre development" EXACT []
synonym: "positive regulation of heart muscle fiber development" EXACT []
synonym: "stimulation of cardiac muscle fiber development" NARROW []
synonym: "up regulation of cardiac muscle fiber development" EXACT []
synonym: "up-regulation of cardiac muscle fiber development" EXACT []
synonym: "upregulation of cardiac muscle fiber development" EXACT []
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0055018 ! regulation of cardiac muscle fiber development
relationship: part_of GO:0055025 ! positive regulation of cardiac muscle tissue development
relationship: positively_regulates GO:0048739 ! cardiac muscle fiber development

[Term]
id: GO:0055021
name: regulation of cardiac muscle tissue growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle growth." [GOC:vk]
is_a: GO:0055024 ! regulation of cardiac muscle tissue development
is_a: GO:0060420 ! regulation of heart growth
relationship: regulates GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0055022
name: negative regulation of cardiac muscle tissue growth
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle growth." [GOC:vk]
synonym: "down regulation of cardiac muscle growth" EXACT []
synonym: "down-regulation of cardiac muscle growth" EXACT []
synonym: "downregulation of cardiac muscle growth" EXACT []
synonym: "inhibition of cardiac muscle growth" NARROW []
synonym: "negative regulation of heart muscle growth" RELATED []
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
relationship: negatively_regulates GO:0055017 ! cardiac muscle tissue growth
relationship: part_of GO:0055026 ! negative regulation of cardiac muscle tissue development

[Term]
id: GO:0055023
name: positive regulation of cardiac muscle tissue growth
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth." [GOC:vk]
synonym: "activation of cardiac muscle growth" NARROW []
synonym: "positive regulation of heart muscle growth" EXACT []
synonym: "stimulation of cardiac muscle growth" NARROW []
synonym: "up regulation of cardiac muscle growth" EXACT []
synonym: "up-regulation of cardiac muscle growth" EXACT []
synonym: "upregulation of cardiac muscle growth" EXACT []
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
relationship: part_of GO:0055025 ! positive regulation of cardiac muscle tissue development
relationship: positively_regulates GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0055024
name: regulation of cardiac muscle tissue development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk]
synonym: "regulation of heart muscle development" EXACT []
is_a: GO:0016202 ! regulation of striated muscle tissue development
relationship: regulates GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055025
name: positive regulation of cardiac muscle tissue development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk]
synonym: "activation of cardiac muscle development" NARROW []
synonym: "positive regulation of heart muscle development" EXACT []
synonym: "stimulation of cardiac muscle development" NARROW []
synonym: "up regulation of cardiac muscle development" EXACT []
synonym: "up-regulation of cardiac muscle development" EXACT []
synonym: "upregulation of cardiac muscle development" EXACT []
is_a: GO:0045844 ! positive regulation of striated muscle tissue development
is_a: GO:0055024 ! regulation of cardiac muscle tissue development
relationship: positively_regulates GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055026
name: negative regulation of cardiac muscle tissue development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk]
synonym: "down regulation of cardiac muscle development" EXACT []
synonym: "down-regulation of cardiac muscle development" EXACT []
synonym: "downregulation of cardiac muscle development" EXACT []
synonym: "inhibition of cardiac muscle development" NARROW []
synonym: "negative regulation of heart muscle development" EXACT []
is_a: GO:0045843 ! negative regulation of striated muscle tissue development
is_a: GO:0055024 ! regulation of cardiac muscle tissue development
relationship: negatively_regulates GO:0048738 ! cardiac muscle tissue development

[Term]
id: GO:0055028
name: cortical microtubule
namespace: cellular_component
def: "Arrays of microtubules underlying and connected to the plasma membrane in the cortical cytosol." [GOC:mtg_sensu]
is_a: GO:0005881 ! cytoplasmic microtubule
is_a: GO:0044448 ! cell cortex part
relationship: part_of GO:0030981 ! cortical microtubule cytoskeleton

[Term]
id: GO:0055029
name: nuclear DNA-directed RNA polymerase complex
namespace: cellular_component
def: "A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu]
is_a: GO:0000428 ! DNA-directed RNA polymerase complex

[Term]
id: GO:0055031
name: gamma-tubulin large complex, equatorial microtubule organizing center
namespace: cellular_component
def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located at equatorial microtubule organizing centers." [GOC:mtg_sensu]
synonym: "gamma-tubulin large complex, eMTOC" EXACT []
synonym: "gamma-tubulin large complex, equatorial microtubule organizing centre" EXACT []
is_a: GO:0000931 ! gamma-tubulin large complex
is_a: GO:0032155 ! cell division site part
relationship: part_of GO:0000923 ! equatorial microtubule organizing center

[Term]
id: GO:0055032
name: gamma-tubulin large complex, spindle pole body
namespace: cellular_component
def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located in the spindle pole body." [GOC:mtg_sensu]
is_a: GO:0000931 ! gamma-tubulin large complex
relationship: part_of GO:0005816 ! spindle pole body

[Term]
id: GO:0055033
name: gamma-tubulin large complex, interphase microtubule organizing center
namespace: cellular_component
def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located at interphase microtubule organizing centers." [GOC:mtg_sensu]
synonym: "gamma-tubulin large complex, iMTOC" EXACT []
synonym: "gamma-tubulin large complex, interphase microtubule organizing centre" EXACT []
is_a: GO:0000931 ! gamma-tubulin large complex
relationship: part_of GO:0031021 ! interphase microtubule organizing center

[Term]
id: GO:0055034
name: Bolwig's organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of the Bolwig's organ over time, from its formation to the mature structure. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [GOC:mtg_sensu]
is_a: GO:0001654 ! eye development

[Term]
id: GO:0055035
name: plastid thylakoid membrane
namespace: cellular_component
def: "The lipid bilayer membrane of any thylakoid within a plastid." [GOC:jic, GOC:rph]
is_a: GO:0042651 ! thylakoid membrane
is_a: GO:0044435 ! plastid part
relationship: part_of GO:0031976 ! plastid thylakoid

[Term]
id: GO:0055036
name: virion membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a virion." [GOC:jic, GOC:rph, PMID:213106]
is_a: GO:0044423 ! virion part

[Term]
id: GO:0055037
name: recycling endosome
namespace: cellular_component
def: "Organelle consisting of networks of 60nm tubules organized around the microtubule organizing centre in some cell types. They transport receptors from late endosomes back to the plasma membrane for recycling and are also involved in membrane trafficking." [GOC:jic, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101]
is_a: GO:0005768 ! endosome

[Term]
id: GO:0055038
name: recycling endosome membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a recycling endosome." [GOC:jic, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101]
is_a: GO:0010008 ! endosome membrane
relationship: part_of GO:0055037 ! recycling endosome

[Term]
id: GO:0055039
name: trichocyst
namespace: cellular_component
def: "A crystalline exocytotic organelle composed of small, acidic proteins existing primarily as disulphide-linked dimers. The trichocyst is an organelle that releases long filamentous proteins that capture predators in \"nets\" to slow them down when the cell is disturbed. The protein is nontoxic and shaped like a long, striated, fibrous shaft." [GOC:jic, GOC:rph, http://www.iscid.org/encyclopedia/, PMID:3667715]
xref: Wikipedia:Trichocyst
is_a: GO:0043264 ! extracellular non-membrane-bounded organelle

[Term]
id: GO:0055040
name: periplasmic flagellum
namespace: cellular_component
def: "Flagellar filaments located in the periplasmic space; characterized in spirochetes, in which they are essential for shape and motility. Composed of a core surrounded by two sheath layers, the flagella rotate to allow migration of the cell through viscous media, which would not be possible using external flagella." [GOC:jic, GOC:rph, PMID:15175283, PMID:1624463]
is_a: GO:0009288 ! bacterial-type flagellum
relationship: part_of GO:0042597 ! periplasmic space

[Term]
id: GO:0055041
name: cyclopentanol dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: cyclopentanol + NAD+ = cyclopentanone + NADH + H+." [EC:1.1.1.163, GOC:jic, GOC:mlg]
synonym: "cyclopentanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.163]
synonym: "cyclopentanol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.163]
xref: EC:1.1.1.163
xref: MetaCyc:CYCLOPENTANOL-DEHYDROGENASE-RXN
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0055042
name: 5-valerolactone hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate." [GOC:jic, GOC:mlg]
is_a: GO:0046573 ! lactonohydrolase activity

[Term]
id: GO:0055043
name: 5-oxovalerate dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+." [GOC:jic, GOC:mlg]
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0055044
name: symplast
namespace: cellular_component
def: "The interconnected cell membranes and intracellular regions of a plant. The interconnections occur via the plasmodesmata." [GOC:mtg_sensu]
subset: goslim_pir
xref: Wikipedia:Symplast
is_a: GO:0005575 ! cellular_component

[Term]
id: GO:0055045
name: antipodal cell degeneration
namespace: biological_process
def: "The process whereby the antipodal cells undergo programmed cell death." [GOC:mtg_plant]
is_a: GO:0010623 ! developmental programmed cell death
relationship: part_of GO:0009561 ! megagametogenesis

[Term]
id: GO:0055046
name: microgametogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of the pollen grain over time, from its formation as the microspore to the mature structure." [GOC:mtg_plant]
synonym: "pollen development from the microspore" EXACT systematic_synonym []
xref: Wikipedia:Microgametogenesis
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0009555 ! pollen development

[Term]
id: GO:0055047
name: generative cell mitosis
namespace: biological_process
def: "The process whereby the generative cell divides by mitosis to form two haploid cells. These will subsequently differentiate into sperm cells." [GOC:mtg_plant]
is_a: GO:0007067 ! mitosis
relationship: part_of GO:0048232 ! male gamete generation

[Term]
id: GO:0055048
name: anastral spindle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the absence of centrosomes. Formation is initiated by the nucleation of microtubules (MTs) in the vicinity of condensed chromatin. MTs then attach to and congress around the chromatin due to activity of microtubule motors. A bipolar spindle is formed by focusing of the terminal ends of the MT array into spindle poles by molecular motors and cross-linking proteins." [GOC:mtg_sensu, GOC:rg, GOC:tb, PMID:15034926]
is_a: GO:0051225 ! spindle assembly

[Term]
id: GO:0055049
name: astral spindle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the presence of centrosomes." [GOC:tb]
is_a: GO:0051225 ! spindle assembly

[Term]
id: GO:0055050
name: astral spindle assembly involved in male meiosis
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the astral spindle in male meiotic cells." [GOC:tb]
is_a: GO:0007053 ! spindle assembly involved in male meiosis
is_a: GO:0055049 ! astral spindle assembly

[Term]
id: GO:0055051
name: ATP-binding cassette (ABC) transporter complex, integrated substrate binding
namespace: cellular_component
def: "A complex for the transport of metabolites out of the cell, consisting of 4 domains: two ATP-binding domains and two membrane spanning domains. In some cases, all 4 domains are contained on 1 polypeptide, while in others one ATP-binding domain and one membrane spanning domain are together on one polypeptide in what is called a \"half transporter\". Two \"half-transporters\" come together to form a functional transporter. Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [GOC:mlg, GOC:mtg_sensu]
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex

[Term]
id: GO:0055052
name: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
namespace: cellular_component
def: "A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [GOC:mlg, GOC:mtg_sensu]
is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex

[Term]
id: GO:0055053
name: mannose:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: mannose + H+ = mannose + H+." [GOC:ct]
is_a: GO:0009679 ! hexose:hydrogen symporter activity
is_a: GO:0015578 ! mannose transmembrane transporter activity

[Term]
id: GO:0055054
name: fructose:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose + H+ = fructose + H+." [GOC:ct]
is_a: GO:0005353 ! fructose transmembrane transporter activity
is_a: GO:0009679 ! hexose:hydrogen symporter activity

[Term]
id: GO:0055055
name: D-glucose:hydrogen symporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. D-glucose is the dextrorotatory D-enantiomer of glucose." [GOC:ct]
is_a: GO:0005356 ! hydrogen:glucose symporter activity
is_a: GO:0055056 ! D-glucose transmembrane transporter activity

[Term]
id: GO:0055056
name: D-glucose transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of the membrane to the other." [GOC:jic, GOC:jsg, GOC:mah]
is_a: GO:0005355 ! glucose transmembrane transporter activity

[Term]
id: GO:0055057
name: neuroblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron." [PMID:11163136, PMID:11250167]
synonym: "neuroblast cell division" EXACT []
is_a: GO:0048103 ! somatic stem cell division
relationship: part_of GO:0007405 ! neuroblast proliferation

[Term]
id: GO:0055058
name: symmetric neuroblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a neuroblast into two equi-potent daughter cells." [GOC:dph]
is_a: GO:0055057 ! neuroblast division

[Term]
id: GO:0055059
name: asymmetric neuroblast division
namespace: biological_process
def: "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
is_a: GO:0055057 ! neuroblast division

[Term]
id: GO:0055060
name: asymmetric neuroblast division resulting in ganglion mother cell formation
namespace: biological_process
def: "Any process resulting in the physical partitioning and separation of a neuroblast into a neuroblast and a ganglion mother cell." [GOC:dph]
is_a: GO:0014017 ! neuroblast fate commitment
is_a: GO:0055059 ! asymmetric neuroblast division

[Term]
id: GO:0055061
name: di-, tri-valent inorganic anion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of divalent or trivalent inorganic anions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
is_a: GO:0055081 ! anion homeostasis

[Term]
id: GO:0055062
name: phosphate ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of phosphate ions within an organism or cell." [GOC:jid, GOC:mah]
is_a: GO:0055061 ! di-, tri-valent inorganic anion homeostasis

[Term]
id: GO:0055063
name: sulfate ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of sulfate ions within an organism or cell." [GOC:jid, GOC:mah]
synonym: "sulphate ion homeostasis" EXACT []
is_a: GO:0055061 ! di-, tri-valent inorganic anion homeostasis

[Term]
id: GO:0055064
name: chloride ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of chloride ions within an organism or cell." [GOC:jid, GOC:mah]
is_a: GO:0055083 ! monovalent inorganic anion homeostasis

[Term]
id: GO:0055065
name: metal ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of metal ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
subset: gosubset_prok
is_a: GO:0055080 ! cation homeostasis

[Term]
id: GO:0055066
name: di-, tri-valent inorganic cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of divalent or trivalent cations within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]
subset: gosubset_prok
is_a: GO:0055080 ! cation homeostasis

[Term]
id: GO:0055067
name: monovalent inorganic cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of monovalent inorganic cations within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
subset: gosubset_prok
is_a: GO:0055080 ! cation homeostasis

[Term]
id: GO:0055068
name: cobalt ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of cobalt ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
synonym: "cobalt homeostasis" BROAD []
is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis

[Term]
id: GO:0055069
name: zinc ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of zinc ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
synonym: "zinc homeostasis" BROAD []
is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis

[Term]
id: GO:0055070
name: copper ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of copper ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
subset: gosubset_prok
synonym: "copper homeostasis" BROAD []
is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis

[Term]
id: GO:0055071
name: manganese ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of manganese ions within an organism or cell." [GOC:jid, GOC:mah]
subset: gosubset_prok
synonym: "manganese homeostasis" BROAD []
is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis

[Term]
id: GO:0055072
name: iron ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of iron ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
subset: gosubset_prok
synonym: "iron homeostasis" BROAD []
is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis

[Term]
id: GO:0055073
name: cadmium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of cadmium ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
synonym: "cadmium homeostasis" EXACT []
is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis

[Term]
id: GO:0055074
name: calcium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]
synonym: "regulation of calcium ion concentration" EXACT []
is_a: GO:0055065 ! metal ion homeostasis
is_a: GO:0055066 ! di-, tri-valent inorganic cation homeostasis

[Term]
id: GO:0055075
name: potassium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of potassium ions within an organism or cell." [GOC:jid, GOC:mah]
is_a: GO:0055065 ! metal ion homeostasis
is_a: GO:0055067 ! monovalent inorganic cation homeostasis

[Term]
id: GO:0055076
name: transition metal ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [GOC:jid, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
subset: gosubset_prok
is_a: GO:0055065 ! metal ion homeostasis

[Term]
id: GO:0055077
name: gap junction hemi-channel activity
namespace: molecular_function
def: "A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction." [GOC:dgh]
synonym: "connexon channel activity" EXACT []
is_a: GO:0022829 ! wide pore channel activity
relationship: part_of GO:0005243 ! gap junction channel activity

[Term]
id: GO:0055078
name: sodium ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of sodium ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
is_a: GO:0055065 ! metal ion homeostasis
is_a: GO:0055067 ! monovalent inorganic cation homeostasis

[Term]
id: GO:0055079
name: aluminum ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of aluminum ions within an organism or cell." [GOC:jid, GOC:lr, GOC:mah]
synonym: "aluminium ion homeostasis" EXACT [GOC:mah]
is_a: GO:0055065 ! metal ion homeostasis

[Term]
id: GO:0055080
name: cation homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of cations within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]
subset: gosubset_prok
is_a: GO:0050801 ! ion homeostasis

[Term]
id: GO:0055081
name: anion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of anions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah]
is_a: GO:0050801 ! ion homeostasis

[Term]
id: GO:0055082
name: cellular chemical homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal equilibrium of a chemical at the level of the cell." [GOC:isa_complete, GOC:jid]
subset: gosubset_prok
is_a: GO:0019725 ! cellular homeostasis
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0055083
name: monovalent inorganic anion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of monovalent inorganic anions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah]
is_a: GO:0055081 ! anion homeostasis

[Term]
id: GO:0055084
name: fruiting body development in response to starvation
namespace: biological_process
def: "The process whose specific outcome is the progression of the fruiting body over time, from its formation to the mature structure. The process begins with a response to a lack of nutrients and ends when the fruiting body is a mature structure." [GOC:mtg_sensu]
is_a: GO:0030582 ! fruiting body development
is_a: GO:0042594 ! response to starvation

[Term]
id: GO:0055085
name: transmembrane transport
namespace: biological_process
def: "The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute." [GOC:jid]
subset: goslim_pombe
xref: Reactome:382551 "Transmembrane transport of small molecules"
xref: Reactome:382556 "ABC-family proteins mediated transport"
xref: Reactome:448617 "ABC-family proteins mediated transport"
xref: Reactome:448618 "Transmembrane transport of small molecules"
xref: Reactome:469743 "ABC-family proteins mediated transport"
xref: Reactome:469744 "Transmembrane transport of small molecules"
xref: Reactome:487452 "ABC-family proteins mediated transport"
xref: Reactome:487453 "Transmembrane transport of small molecules"
xref: Reactome:507409 "ABC-family proteins mediated transport"
xref: Reactome:507410 "Transmembrane transport of small molecules"
xref: Reactome:517410 "ABC-family proteins mediated transport"
xref: Reactome:517411 "Transmembrane transport of small molecules"
xref: Reactome:526284 "ABC-family proteins mediated transport"
xref: Reactome:526285 "Transmembrane transport of small molecules"
xref: Reactome:531148 "ABC-family proteins mediated transport"
xref: Reactome:531149 "Transmembrane transport of small molecules"
xref: Reactome:536519 "ABC-family proteins mediated transport"
xref: Reactome:536520 "Transmembrane transport of small molecules"
xref: Reactome:542237 "ABC-family proteins mediated transport"
xref: Reactome:542238 "Transmembrane transport of small molecules"
xref: Reactome:547954 "Transmembrane transport of small molecules"
xref: Reactome:552197 "ABC-family proteins mediated transport"
xref: Reactome:552198 "Transmembrane transport of small molecules"
xref: Reactome:557783 "ABC-family proteins mediated transport"
xref: Reactome:557784 "Transmembrane transport of small molecules"
xref: Reactome:568396 "ABC-family proteins mediated transport"
xref: Reactome:568397 "Transmembrane transport of small molecules"
xref: Reactome:581598 "ABC-family proteins mediated transport"
xref: Reactome:581599 "Transmembrane transport of small molecules"
xref: Reactome:585791 "ABC-family proteins mediated transport"
xref: Reactome:585792 "Transmembrane transport of small molecules"
xref: Reactome:592494 "ABC-family proteins mediated transport"
xref: Reactome:592495 "Transmembrane transport of small molecules"
xref: Reactome:597317 "ABC-family proteins mediated transport"
xref: Reactome:597318 "Transmembrane transport of small molecules"
xref: Reactome:598116 "ABC-family proteins mediated transport"
xref: Reactome:598117 "Transmembrane transport of small molecules"
xref: Reactome:599664 "ABC-family proteins mediated transport"
xref: Reactome:599665 "Transmembrane transport of small molecules"
xref: Reactome:600589 "ABC-family proteins mediated transport"
xref: Reactome:600590 "Transmembrane transport of small molecules"
xref: Reactome:602478 "ABC-family proteins mediated transport"
xref: Reactome:602479 "Transmembrane transport of small molecules"
is_a: GO:0006810 ! transport
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0055086
name: nucleobase, nucleoside and nucleotide metabolic process
namespace: biological_process
def: "The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides." [GOC:vw]
subset: goslim_pombe
subset: gosubset_prok
synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT []
xref: Reactome:15869 "Metablism of nucleotides"
xref: Reactome:448478 "Metablism of nucleotides"
xref: Reactome:469608 "Metablism of nucleotides"
xref: Reactome:487327 "Metablism of nucleotides"
xref: Reactome:507278 "Metablism of nucleotides"
xref: Reactome:517298 "Metablism of nucleotides"
xref: Reactome:526177 "Metablism of nucleotides"
xref: Reactome:531067 "Metablism of nucleotides"
xref: Reactome:536446 "Metablism of nucleotides"
xref: Reactome:542144 "Metablism of nucleotides"
xref: Reactome:547508 "Metablism of nucleotides"
xref: Reactome:552100 "Metablism of nucleotides"
xref: Reactome:557684 "Metablism of nucleotides"
xref: Reactome:568302 "Metablism of nucleotides"
xref: Reactome:581504 "Metablism of nucleotides"
xref: Reactome:585751 "Metablism of nucleotides"
xref: Reactome:592420 "Metablism of nucleotides"
xref: Reactome:595288 "Metablism of nucleotides"
xref: Reactome:597277 "Metablism of nucleotides"
xref: Reactome:598083 "Metablism of nucleotides"
xref: Reactome:599589 "Metablism of nucleotides"
xref: Reactome:600547 "Metablism of nucleotides"
xref: Reactome:602400 "Metablism of nucleotides"
is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0055087
name: Ski complex
namespace: cellular_component
def: "A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p." [GOC:mcc, PMID:10744028, PMID:15703439, PMID:16043509, PMID:18042677]
xref: Wikipedia:Ski_complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0055088
name: lipid homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of lipid within an organism or cell." [GOC:BHF, GOC:rl]
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0055089
name: fatty acid homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of fatty acid within an organism or cell." [GOC:BHF, GOC:rl]
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0055090
name: acylglycerol homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of acylglycerol within an organism or cell." [GOC:BHF, GOC:rl]
synonym: "glyceride homeostasis" EXACT []
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0055091
name: phospholipid homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of phospholipid within an organism or cell." [GOC:BHF, GOC:rl]
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0055092
name: sterol homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of sterol within an organism or cell." [GOC:BHF, GOC:rl]
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0055093
name: response to hyperoxia
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension." [GOC:kmv]
synonym: "response to hyperoxic stress" EXACT []
synonym: "response to increased oxygen tension" EXACT []
is_a: GO:0006950 ! response to stress
is_a: GO:0070482 ! response to oxygen levels

[Term]
id: GO:0055094
name: response to lipoprotein stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein stimulus." [GOC:BHF, GOC:rl]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0055095
name: lipoprotein mediated signaling
namespace: biological_process
def: "A series of molecular signals mediated by the detection of lipoprotein." [GOC:rl]
synonym: "lipoprotein mediated signalling " EXACT []
is_a: GO:0007242 ! intracellular signaling cascade
relationship: part_of GO:0071402 ! cellular response to lipoprotein stimulus

[Term]
id: GO:0055096
name: low-density lipoprotein mediated signaling
namespace: biological_process
def: "A series of molecular signals mediated by the detection of low-density lipoprotein." [GOC:BHF, GOC:rl]
synonym: "low-density lipoprotein mediated signalling" EXACT []
is_a: GO:0055095 ! lipoprotein mediated signaling
relationship: part_of GO:0071404 ! cellular response to low-density lipoprotein stimulus

[Term]
id: GO:0055097
name: high density lipoprotein mediated signaling
namespace: biological_process
def: "A series of molecular signals mediated by the detection of high density lipoprotein." [GOC:BHF, GOC:rl]
synonym: "high density lipoprotein mediated signalling" EXACT []
is_a: GO:0055095 ! lipoprotein mediated signaling
relationship: part_of GO:0071403 ! cellular response to high density lipoprotein stimulus

[Term]
id: GO:0055098
name: response to low-density lipoprotein stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein stimulus." [GOC:BHF, GOC:rl]
is_a: GO:0055094 ! response to lipoprotein stimulus

[Term]
id: GO:0055099
name: response to high density lipoprotein stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein stimulus." [GOC:BHF, GOC:rl]
is_a: GO:0055094 ! response to lipoprotein stimulus

[Term]
id: GO:0055100
name: adiponectin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism." [GOC:BHF, GOC:rl, PMID:15210937]
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0055101
name: glycerophospholipase inhibitor activity
namespace: molecular_function
def: "OBSOLETE. Stops, prevents or reduces the activity of a glycerophospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai, GOC:BHF, GOC:rl]
comment: This term was made obsolete because it refers to a non-existent molecular function term, 'glycerophosphate activity', which also cannot be found in the literature.
is_obsolete: true

[Term]
id: GO:0055102
name: lipase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid." [GOC:BHF, GOC:rl]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0055103
name: ligase regulator activity
namespace: molecular_function
def: "Modulates the activity of a ligase." [GOC:BHF, GOC:rl]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0055104
name: ligase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a ligase." [GOC:BHF, GOC:rl]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0055105
name: ubiquitin-protein ligase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a ubiquitin-protein ligase." [GOC:BHF, GOC:rl]
is_a: GO:0055104 ! ligase inhibitor activity
is_a: GO:0055106 ! ubiquitin-protein ligase regulator activity

[Term]
id: GO:0055106
name: ubiquitin-protein ligase regulator activity
namespace: molecular_function
def: "Modulates the activity of a ubiquitin-protein ligase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl]
is_a: GO:0055103 ! ligase regulator activity

[Term]
id: GO:0055107
name: Golgi to secretory granule transport
namespace: biological_process
def: "The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex." [GOC:jid, http://cancerweb.ncl.ac.uk]
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0055108
name: Golgi to transport vesicle transport
namespace: biological_process
def: "The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis." [GOC:jid]
is_a: GO:0046907 ! intracellular transport
relationship: part_of GO:0048193 ! Golgi vesicle transport

[Term]
id: GO:0055109
name: invagination involved in gastrulation with mouth forming second
namespace: biological_process
def: "The infolding of the epithelial sheet into the embryo involved in deuterostomic gastrulation." [ISBN:0878932437]
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0001702 ! gastrulation with mouth forming second

[Term]
id: GO:0055110
name: involution involved in gastrulation with mouth forming second
namespace: biological_process
def: "The inturning of an epithelial sheet over the basal surface of an outer layer involved in deuterostomic gastrulation." [ISBN:0878932437]
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0001702 ! gastrulation with mouth forming second

[Term]
id: GO:0055111
name: ingression involved in gastrulation with mouth forming second
namespace: biological_process
def: "The migration of individual cells into the embryo involved in deuterostomic gastrulation." [ISBN:0878932437]
is_a: GO:0042074 ! cell migration involved in gastrulation
relationship: part_of GO:0001702 ! gastrulation with mouth forming second

[Term]
id: GO:0055112
name: delamination involved in gastrulation with mouth forming second
namespace: biological_process
def: "The splitting or migration of one epithelial sheet into two involved in the process of deuterostomic gastrulation." [ISBN:0878932437]
is_a: GO:0060232 ! delamination
relationship: part_of GO:0001702 ! gastrulation with mouth forming second

[Term]
id: GO:0055113
name: epiboly involved in gastrulation with mouth forming second
namespace: biological_process
def: "The expansion of one cell sheet over other cells involved in deuterostomic gastrulation." [ISBN:0878932437]
is_a: GO:0002011 ! morphogenesis of an epithelial sheet
relationship: part_of GO:0001702 ! gastrulation with mouth forming second

[Term]
id: GO:0055114
name: oxidation reduction
namespace: biological_process
def: "The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph]
subset: gosubset_prok
synonym: "oxidoreductase process" EXACT systematic_synonym []
xref: Wikipedia:Redox
is_a: GO:0008152 ! metabolic process

[Term]
id: GO:0055115
name: diapause
namespace: biological_process
def: "A neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:ds, GOC:jid]
xref: Wikipedia:Diapause
is_a: GO:0022611 ! dormancy process

[Term]
id: GO:0055116
name: reproductive diapause
namespace: biological_process
def: "A form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:ds, GOC:jid]
is_a: GO:0055115 ! diapause

[Term]
id: GO:0055117
name: regulation of cardiac muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd]
is_a: GO:0006942 ! regulation of striated muscle contraction
is_a: GO:0008016 ! regulation of heart contraction
relationship: regulates GO:0060048 ! cardiac muscle contraction

[Term]
id: GO:0055118
name: negative regulation of cardiac muscle contraction
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd]
is_a: GO:0045988 ! negative regulation of striated muscle contraction
is_a: GO:0055117 ! regulation of cardiac muscle contraction
relationship: negatively_regulates GO:0060048 ! cardiac muscle contraction

[Term]
id: GO:0055119
name: relaxation of cardiac muscle
namespace: biological_process
def: "The process whereby the extent of cardiac muscle contraction is reduced." [GOC:ecd]
is_a: GO:0055118 ! negative regulation of cardiac muscle contraction
is_a: GO:0090075 ! relaxation of muscle

[Term]
id: GO:0055120
name: striated muscle dense body
namespace: cellular_component
def: "A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere." [GOC:kmv, PMID:17492481]
is_a: GO:0044449 ! contractile fiber part

[Term]
id: GO:0055121
name: response to high fluence blue light stimulus by blue high-fluence system
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a high fluence blue light stimulus by the blue high-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue high-fluence system responds to blue light at levels between 100 and 1000 micromols/m2." [GOC:mtg_far_red]
synonym: "response to high fluence blue light" BROAD []
synonym: "response to high fluence blue light by bhf system" RELATED []
is_a: GO:0009637 ! response to blue light
is_a: GO:0009644 ! response to high light intensity

[Term]
id: GO:0055122
name: response to very low light intensity stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec." [GOC:mtg_far_red]
is_a: GO:0009642 ! response to light intensity

[Term]
id: GO:0055123
name: digestive system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jid]
is_a: GO:0048731 ! system development

[Term]
id: GO:0055124
name: premature neural plate formation
namespace: biological_process
def: "The formation of the neural plate before the appropriate time." [GOC:jid]
is_obsolete: true

[Term]
id: GO:0055125
name: Nic96 complex
namespace: cellular_component
def: "A protein complex that forms part of the nuclear pore complex, and is required for its correct assembly. In Saccharomyces cerevisiae Nic96 contains Nsp1p, Nup57p, Nup49p, and Nic96p." [GOC:jh, PMID:12791264, PMID:15741174]
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:0055126
name: Nup82 complex
namespace: cellular_component
def: "A protein complex that forms part of the nuclear pore complex. It forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p, and is required for proper localization of Nup116p. In Saccharomyces cerevisiae this complex contains Nup82p, Nsp1p, Nup159p, Nup116p, and Gle2p." [GOC:jh, PMID:12791264, PMID:15741174]
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:0055127
name: vibrational conductance of sound to the inner ear
namespace: biological_process
def: "The series of events involved in the perception of sound vibration. The vibration is transmitted via ossicles to the inner ear." [GOC:mh]
is_a: GO:0032501 ! multicellular organismal process
relationship: part_of GO:0007605 ! sensory perception of sound

[Term]
id: GO:0055129
name: L-proline biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:ecd]
synonym: "pyrrolidine-2-carboxylic acid biosynthetic process" EXACT []
is_a: GO:0006561 ! proline biosynthetic process

[Term]
id: GO:0055130
name: D-alanine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of D-alanine, the D-enantiomer of the amino acid alanine." [GOC:ecd]
synonym: "(2R)-2-aminopropanoic acid catabolic process" EXACT []
is_a: GO:0019478 ! D-amino acid catabolic process
is_a: GO:0046436 ! D-alanine metabolic process

[Term]
id: GO:0055131
name: C3HC4-type RING finger domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway." [GOC:amm, InterPro:IPR001841, InterPro:IPR018957]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0060001
name: minus-end directed microfilament motor activity
namespace: molecular_function
def: "Catalysis of movement along a microfilament towards the minus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The minus end of an actin filament is the end that does not preferentially add actin monomers." [GOC:dph, PMID:10519557]
synonym: "minus-end directed actin filament motor activity" RELATED [GOC:dph]
synonym: "minus-end directed actin-filament motor activity" EXACT [GOC:dph]
synonym: "pointed-end directed actin-filament motor activity" EXACT [GOC:dph]
is_a: GO:0000146 ! microfilament motor activity

[Term]
id: GO:0060002
name: plus-end directed microfilament motor activity
namespace: molecular_function
def: "Catalysis of movement along a microfilament towards the plus end, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). The plus end of an actin filament is the end that preferentially adds actin monomers." [GOC:dph, PMID:10519557]
synonym: "barbed-end directed actin-filament motor activity" EXACT [GOC:dph]
synonym: "plus-end directed actin filament motor activity" RELATED [GOC:dph]
synonym: "plus-end directed actin-filament motor activity" EXACT [GOC:dph]
is_a: GO:0000146 ! microfilament motor activity

[Term]
id: GO:0060003
name: copper ion export
namespace: biological_process
def: "The directed movement of copper ions out of a cell or organelle." [GOC:dph]
synonym: "copper export" EXACT [GOC:dph]
is_a: GO:0006825 ! copper ion transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0060004
name: reflex
namespace: biological_process
def: "An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness." [GOC:dph, ISBN:087797099]
xref: Wikipedia:Reflex
is_a: GO:0009605 ! response to external stimulus

[Term]
id: GO:0060005
name: vestibular reflex
namespace: biological_process
def: "A reflex process by which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [PMID:11784757]
is_a: GO:0060004 ! reflex

[Term]
id: GO:0060006
name: angular vestibuloocular reflex
namespace: biological_process
def: "A vestibular reflex by which a response to an angular acceleration stimulus begins with an afferent nerve impulse from a receptor in the semi-circular canal and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [GOC:dph, PMID:11784757]
is_a: GO:0060005 ! vestibular reflex

[Term]
id: GO:0060007
name: linear vestibuloocular reflex
namespace: biological_process
def: "A vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [GOC:dph, PMID:11784757]
is_a: GO:0060005 ! vestibular reflex

[Term]
id: GO:0060008
name: Sertoli cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0008584 ! male gonad development

[Term]
id: GO:0060009
name: Sertoli cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060008 ! Sertoli cell differentiation

[Term]
id: GO:0060010
name: Sertoli cell fate commitment
namespace: biological_process
def: "The process by which the cellular identity of Sertoli cells is acquired and determined." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0060008 ! Sertoli cell differentiation

[Term]
id: GO:0060011
name: Sertoli cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph]
is_a: GO:0008283 ! cell proliferation
is_a: GO:0048610 ! reproductive cellular process
relationship: part_of GO:0008584 ! male gonad development

[Term]
id: GO:0060012
name: synaptic transmission, glycinergic
namespace: biological_process
def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dph]
synonym: "glycinergic synaptic transmission" EXACT []
is_a: GO:0007270 ! nerve-nerve synaptic transmission

[Term]
id: GO:0060013
name: righting reflex
namespace: biological_process
def: "A reflex process in which an animal immediately tries to turn over after being placed in a supine position." [GOC:dph, PMID:8635460]
synonym: "righting response" EXACT [GOC:dph]
is_a: GO:0060004 ! reflex

[Term]
id: GO:0060014
name: granulosa cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals." [GOC:dph]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0060015
name: granulosa cell fate commitment
namespace: biological_process
def: "The cell fate commitment of precursor cells that will become granulosa cells." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0060014 ! granulosa cell differentiation

[Term]
id: GO:0060016
name: granulosa cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a granulosa cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a granulosa cell fate." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060014 ! granulosa cell differentiation

[Term]
id: GO:0060017
name: parathyroid gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the parathyroid gland over time, from its formation to the mature structure. The parathyroid gland is an organ specialised for secretion of parathyroid hormone." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0048732 ! gland development
relationship: part_of GO:0035270 ! endocrine system development

[Term]
id: GO:0060018
name: astrocyte fate commitment
namespace: biological_process
def: "The commitment of a cells to a specific astrocyte fate and its restriction to develop only into an astrocyte." [GOC:dph]
is_a: GO:0021781 ! glial cell fate commitment
relationship: part_of GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0060019
name: radial glial cell differentiation
namespace: biological_process
def: "The process whereby neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0060020
name: Bergmann glial cell differentiation
namespace: biological_process
def: "The process whereby neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, PMID:10375501]
is_a: GO:0048708 ! astrocyte differentiation

[Term]
id: GO:0060021
name: palate development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The palate is the partition that separates the nasal and oral cavities." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "palatum development" EXACT [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0060022
name: hard palate development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "palatum durum development" EXACT [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060021 ! palate development

[Term]
id: GO:0060023
name: soft palate development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the soft palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "palatum molle development" EXACT [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "velum palatum development" EXACT [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060021 ! palate development

[Term]
id: GO:0060024
name: rhythmic synaptic transmission
namespace: biological_process
def: "Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit." [GOC:dph]
is_a: GO:0050804 ! regulation of synaptic transmission

[Term]
id: GO:0060025
name: regulation of synaptic activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell." [GOC:dph, GOC:tb]
is_a: GO:0050804 ! regulation of synaptic transmission
relationship: part_of GO:0050803 ! regulation of synapse structure and activity

[Term]
id: GO:0060026
name: convergent extension
namespace: biological_process
def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis." [GOC:df, GOC:dph, PMID:12062082]
xref: Wikipedia:Convergent_extension
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0060027
name: convergent extension involved in gastrulation
namespace: biological_process
def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:dph, PMID:12062082]
is_a: GO:0060026 ! convergent extension
relationship: part_of GO:0007369 ! gastrulation

[Term]
id: GO:0060028
name: convergent extension involved in axis elongation
namespace: biological_process
def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism." [GOC:dph, PMID:12062082]
is_a: GO:0060026 ! convergent extension
relationship: part_of GO:0003401 ! axis elongation

[Term]
id: GO:0060029
name: convergent extension involved in organogenesis
namespace: biological_process
def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ." [GOC:dph, PMID:12062082]
is_a: GO:0060026 ! convergent extension

[Term]
id: GO:0060030
name: dorsal convergence
namespace: biological_process
def: "The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement." [GOC:df, GOC:dph, PMID:12062082]
is_a: GO:0042074 ! cell migration involved in gastrulation
relationship: part_of GO:0060027 ! convergent extension involved in gastrulation

[Term]
id: GO:0060031
name: mediolateral intercalation
namespace: biological_process
def: "The interdigitation of cells along the mediolateral axis during gastrulation." [GOC:df, GOC:dph, PMID:12062082]
is_a: GO:0042074 ! cell migration involved in gastrulation
relationship: part_of GO:0060027 ! convergent extension involved in gastrulation

[Term]
id: GO:0060032
name: notochord regression
namespace: biological_process
def: "The developmental process by which the stucture of the notochord is destroyed in an embryo." [GOC:dph]
is_a: GO:0060033 ! anatomical structure regression
relationship: part_of GO:0048570 ! notochord morphogenesis

[Term]
id: GO:0060033
name: anatomical structure regression
namespace: biological_process
def: "The developmental process by which an anatomical stucture is destroyed as a part of its normal progression." [GOC:dph]
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0060034
name: notochord cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features cells that make up the notochord. Differentiation includes the processes involved in commitment of a cell to a notochord cell fate." [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030903 ! notochord development

[Term]
id: GO:0060035
name: notochord cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060034 ! notochord cell differentiation

[Term]
id: GO:0060036
name: notochord cell vacuolation
namespace: biological_process
def: "The assembly and arrangement of a vacuole within a cell of the notochord." [GOC:cb, GOC:dph, PMID:10964477]
is_a: GO:0007033 ! vacuole organization
relationship: part_of GO:0060035 ! notochord cell development

[Term]
id: GO:0060037
name: pharyngeal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear." [GOC:dph]
is_a: GO:0048731 ! system development
relationship: part_of GO:0043009 ! chordate embryonic development

[Term]
id: GO:0060038
name: cardiac muscle cell proliferation
namespace: biological_process
def: "The expansion of a cardiac muscle cell population by cell division." [GOC:dph, GOC:rph, PMID:11161571]
synonym: "cardiac myocyte proliferation" EXACT []
synonym: "cardiomyocyte proliferation" RELATED [GOC:dph, PMID:10074473]
synonym: "heart muscle cell proliferation" EXACT []
is_a: GO:0014855 ! striated muscle cell proliferation
relationship: part_of GO:0055017 ! cardiac muscle tissue growth

[Term]
id: GO:0060039
name: pericardium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery." [GOC:dph, GOC:rph, PMID:15138308, PMID:16376438]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0060040
name: retinal bipolar neuron differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a bipolar cell, the last neuron to be generated in the retina." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]
is_a: GO:0030182 ! neuron differentiation
relationship: part_of GO:0003407 ! neural retina development
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye

[Term]
id: GO:0060041
name: retina development in camera-type eye
namespace: biological_process
alt_id: GO:0002073
def: "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:bf, GOC:dph, ISBN:0815340729]
synonym: "retina development in camera-style eye" EXACT []
synonym: "retinal development" RELATED [GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0060042
name: retina morphogenesis in camera-type eye
namespace: biological_process
def: "The process by which the anatomical structure of the retina is generated and organized. Morphogenesis pertains to the creation of form." [GOC:bf, GOC:dph, GOC:mtg_sensu]
synonym: "retina morphogenesis in camera-style eye" EXACT []
synonym: "retinogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048593 ! camera-type eye morphogenesis
relationship: part_of GO:0060041 ! retina development in camera-type eye

[Term]
id: GO:0060043
name: regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph]
synonym: "regulation of heart muscle cell proliferation" EXACT []
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
relationship: regulates GO:0060038 ! cardiac muscle cell proliferation

[Term]
id: GO:0060044
name: negative regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph]
synonym: "negative regulation of heart muscle cell proliferation" EXACT []
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation
relationship: negatively_regulates GO:0060038 ! cardiac muscle cell proliferation

[Term]
id: GO:0060045
name: positive regulation of cardiac muscle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph]
synonym: "positive regulation of heart muscle cell proliferation" RELATED []
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation
relationship: positively_regulates GO:0060038 ! cardiac muscle cell proliferation

[Term]
id: GO:0060046
name: regulation of acrosome reaction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the acrosome reaction." [GOC:dph]
is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis
relationship: regulates GO:0007340 ! acrosome reaction

[Term]
id: GO:0060047
name: heart contraction
namespace: biological_process
def: "The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph]
synonym: "cardiac contraction" RELATED []
synonym: "heart beating" EXACT []
synonym: "hemolymph circulation" RELATED []
is_a: GO:0003015 ! heart process
relationship: part_of GO:0008015 ! blood circulation

[Term]
id: GO:0060048
name: cardiac muscle contraction
namespace: biological_process
def: "Muscle contraction of cardiac muscle tissue." [GOC:dph]
synonym: "heart muscle contraction" EXACT []
is_a: GO:0006941 ! striated muscle contraction
relationship: part_of GO:0060047 ! heart contraction

[Term]
id: GO:0060049
name: regulation of protein amino acid glycosylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein amino acid glycosylation. Protein amino acid glycosylation is the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph]
is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0006486 ! protein amino acid glycosylation

[Term]
id: GO:0060050
name: positive regulation of protein amino acid glycosylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein amino acid glycosylation is the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph]
is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0060049 ! regulation of protein amino acid glycosylation
relationship: positively_regulates GO:0006486 ! protein amino acid glycosylation

[Term]
id: GO:0060051
name: negative regulation of protein amino acid glycosylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein amino acid glycosylation is the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph]
is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0060049 ! regulation of protein amino acid glycosylation
relationship: negatively_regulates GO:0006486 ! protein amino acid glycosylation

[Term]
id: GO:0060052
name: neurofilament cytoskeleton organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising neurofilaments and their associated proteins." [GOC:dph]
synonym: "neurofilament cytoskeleton organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0045104 ! intermediate filament cytoskeleton organization

[Term]
id: GO:0060053
name: neurofilament cytoskeleton
namespace: cellular_component
def: "Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons." [GOC:dph]
is_a: GO:0045111 ! intermediate filament cytoskeleton

[Term]
id: GO:0060054
name: positive regulation of epithelial cell proliferation involved in wound healing
namespace: biological_process
def: "Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury." [GOC:dph]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0060055
name: angiogenesis involved in wound healing
namespace: biological_process
def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph, PMID:15039218]
is_a: GO:0001525 ! angiogenesis
relationship: part_of GO:0042060 ! wound healing

[Term]
id: GO:0060056
name: mammary gland involution
namespace: biological_process
def: "The tissue remodeling that removes differentiated mammary epithelia during weaning." [GOC:dph, PMID:15282149]
is_a: GO:0048771 ! tissue remodeling
relationship: part_of GO:0060443 ! mammary gland morphogenesis

[Term]
id: GO:0060057
name: apoptosis involved in mammary gland involution
namespace: biological_process
def: "The form of programmed cell death that triggers the activity of proteolytic caspases, whose actions dismantle the mammary epithelial cells resulting in their death." [GOC:dph]
is_a: GO:0060561 ! apoptosis involved in morphogenesis
relationship: part_of GO:0060056 ! mammary gland involution

[Term]
id: GO:0060058
name: positive regulation of apoptosis involved in mammary gland involution
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptosis of mammary epithelial cells during mammary gland involution." [GOC:dph, PMID:15282149]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0034105 ! positive regulation of tissue remodeling
is_a: GO:0043065 ! positive regulation of apoptosis
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0060284 ! regulation of cell development
relationship: positively_regulates GO:0060057 ! apoptosis involved in mammary gland involution

[Term]
id: GO:0060059
name: embryonic retina morphogenesis in camera-type eye
namespace: biological_process
def: "The process by which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage . Morphogenesis pertains to the creation of form." [GOC:dgh, GOC:dph]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye

[Term]
id: GO:0060060
name: post-embryonic retina morphogenesis in camera-type eye
namespace: biological_process
def: "The process by which the anatomical structure of the retina is generated and organized in a camera-type eye during the post-embryonic life stage . Morphogenesis pertains to the creation of form." [GOC:dgh, GOC:dph]
is_a: GO:0009886 ! post-embryonic morphogenesis
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye

[Term]
id: GO:0060061
name: Spemann organizer formation
namespace: biological_process
def: "Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:dph, GOC:ref]
synonym: "Spemann's organizer formation" EXACT []
synonym: "Spemann-Mangold organizer formation" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0031128 ! developmental induction

[Term]
id: GO:0060062
name: Spemann organizer formation at the dorsal lip of the blastopore
namespace: biological_process
def: "Formation of the specialized region at the dorsal lip of the blatopore of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:dph, PMID:9442883]
comment: Occurs in amphibia, cephalochordates, cyclostomes and cartilaginous fish.
synonym: "Spemann's organizer formation at the dorsal lip of the blastopore" EXACT []
synonym: "Spemann-Mangold organizer formation at the dorsal lip of the blastopore" EXACT []
is_a: GO:0060061 ! Spemann organizer formation

[Term]
id: GO:0060063
name: Spemann organizer formation at the embryonic shield
namespace: biological_process
def: "Formation of the specialized region of the embryonic shield of the embryo that acts as the main signaling center establishing the teleost body plan." [GOC:dph, PMID:9442883]
comment: Occurs in Teleost fish.
synonym: "Spemann's organizer formation at the embryonic shield" EXACT []
synonym: "Spemann-Mangold organizer formation at the embryonic shield" EXACT []
is_a: GO:0060061 ! Spemann organizer formation

[Term]
id: GO:0060064
name: Spemann organizer formation at the anterior end of the primitive streak
namespace: biological_process
def: "Formation of the specialized region at the anterior end of the primitive streak of the embryo that acts as the main signaling center establishing the body plan." [GOC:dph, PMID:9442883]
comment: Occurs in reptiles, birds and mammals.
synonym: "Spemann organizer formation in amniotes" RELATED []
synonym: "Spemann's organizer formation at the anterior end of the primitive streak" EXACT []
synonym: "Spemann-Mangold organizer formation at the anterior end of the primitive streak" RELATED []
is_a: GO:0060061 ! Spemann organizer formation

[Term]
id: GO:0060065
name: uterus development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure." [GOC:dph, GOC:ec]
synonym: "Mullerian tract development" RELATED []
is_a: GO:0048513 ! organ development
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0060066
name: fallopian tube development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the fallopian tubes over time, from their formation to the mature structures." [GOC:dph, GOC:ec]
synonym: "Mullerian tract development" RELATED []
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0060067
name: cervix development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the cervix over time, from its formation to the mature structure." [GOC:dph, GOC:ec]
synonym: "Mullerian tract development" RELATED []
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0060068
name: vagina development
namespace: biological_process
def: "The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure." [GOC:dph, GOC:ec]
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0060069
name: Wnt receptor signaling pathway, regulating spindle positioning
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with the positioning of the mitotic spindle." [GOC:bf, GOC:dph, PMID:11532397]
synonym: "non-canonical Wnt signaling pathway" BROAD []
synonym: "Wnt receptor signalling pathway, regulating spindle positioning" EXACT []
is_a: GO:0016055 ! Wnt receptor signaling pathway

[Term]
id: GO:0060070
name: Wnt receptor signaling pathway through beta-catenin
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397]
synonym: "canonical Wnt signaling pathway" EXACT []
synonym: "frizzled-1 receptor signaling pathway" NARROW []
synonym: "Wnt receptor signalling pathway through beta-catenin" EXACT []
is_a: GO:0016055 ! Wnt receptor signaling pathway

[Term]
id: GO:0060071
name: Wnt receptor signaling pathway, planar cell polarity pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity." [GOC:bf, GOC:dph, PMID:11532397]
synonym: "non-canonical Wnt signaling pathway" RELATED [GOC:bf]
synonym: "PCP pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "Wnt receptor signalling pathway, planar cell polarity pathway" EXACT []
synonym: "Wnt-JNK signaling pathway" RELATED [GOC:bf]
synonym: "Wnt-PCP signaling pathway" RELATED [GOC:rph]
is_a: GO:0016055 ! Wnt receptor signaling pathway
is_a: GO:0090175 ! regulation of establishment of planar polarity

[Term]
id: GO:0060072
name: large conductance calcium-activated potassium channel activity
namespace: molecular_function
alt_id: GO:0022895
def: "Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729, PMID:17115074]
synonym: "BK calcium-activated potassium channel activity" EXACT []
synonym: "BK channel activity" RELATED []
synonym: "BK KCa channels" EXACT []
synonym: "large conductance KCa channels" EXACT []
is_a: GO:0015269 ! calcium-activated potassium channel activity

[Term]
id: GO:0060073
name: micturition
namespace: biological_process
def: "The regulation of body fluids process by which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body." [GOC:dph]
synonym: "urination" EXACT []
synonym: "urine voiding" EXACT []
xref: Wikipedia:Urination
is_a: GO:0003014 ! renal system process
is_a: GO:0007588 ! excretion

[Term]
id: GO:0060074
name: synapse maturation
namespace: biological_process
def: "The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development." [GOC:dph, GOC:ef]
synonym: "synaptic maturation" EXACT []
is_a: GO:0021700 ! developmental maturation
is_a: GO:0050808 ! synapse organization
relationship: part_of GO:0007399 ! nervous system development

[Term]
id: GO:0060075
name: regulation of resting membrane potential
namespace: biological_process
def: "Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized." [GOC:dph, GOC:ef, ISBN:0195088433]
synonym: "regulation of resting potential" EXACT []
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0060076
name: excitatory synapse
namespace: cellular_component
def: "A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef]
xref: Wikipedia:Excitatory_synapse
is_a: GO:0045202 ! synapse

[Term]
id: GO:0060077
name: inhibitory synapse
namespace: cellular_component
def: "A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef]
xref: Wikipedia:Inhibitory_postsynaptic_potential
is_a: GO:0045202 ! synapse

[Term]
id: GO:0060078
name: regulation of postsynaptic membrane potential
namespace: biological_process
def: "Any process that modulates the establishment or extent of the postsynaptic membrane potential, which is generated by changes in the membrane potential of the post synaptic neuron that receives information at a synapse. The presynaptic neuron releases neurotransmitters into the synaptic cleft which bind to receptors on the postsynaptic neuron. After being bound by the neurotransmitters, these receptors can open or close an ion channel, allowing ions to enter or leave the cell and therefore altering the membrane potential of the postsynaptic neuron." [GOC:dph, GOC:ef]
is_a: GO:0042391 ! regulation of membrane potential
relationship: part_of GO:0007268 ! synaptic transmission

[Term]
id: GO:0060079
name: regulation of excitatory postsynaptic membrane potential
namespace: biological_process
def: "Any process that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP) which is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dph, GOC:ef]
synonym: "EPSP" RELATED []
is_a: GO:0051899 ! membrane depolarization
is_a: GO:0060078 ! regulation of postsynaptic membrane potential

[Term]
id: GO:0060080
name: regulation of inhibitory postsynaptic membrane potential
namespace: biological_process
def: "Any process that modulates the establishment or extent of the inhibitory postsynaptic potential (IPSP) which is a temporay decrease in postsynaptic potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential." [GOC:dph, GOC:ef]
synonym: "IPSP" RELATED []
is_a: GO:0060078 ! regulation of postsynaptic membrane potential
is_a: GO:0060081 ! membrane hyperpolarization

[Term]
id: GO:0060081
name: membrane hyperpolarization
namespace: biological_process
def: "The process in which membrane potential changes in the hyperpolarizing direction from the resting potential, usually from negative to more negative." [GOC:dph]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0060082
name: eye blink reflex
namespace: biological_process
def: "The reflex process by which a mechanical stimulus applied to the eye elicits a response of the eyelid closing." [GOC:dph, PMID:2913208]
synonym: "nictitating membrane reflex" EXACT []
is_a: GO:0060004 ! reflex

[Term]
id: GO:0060083
name: smooth muscle contraction involved in micturition
namespace: biological_process
def: "The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body." [GOC:dph, PMID:15827347]
synonym: "smooth muscle contraction involved in urination" RELATED []
synonym: "urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:dph]
is_a: GO:0014832 ! urinary bladder smooth muscle contraction
relationship: part_of GO:0060073 ! micturition

[Term]
id: GO:0060084
name: synaptic transmission involved in micturition
namespace: biological_process
def: "The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body." [GOC:dph, PMID:15827347]
synonym: "synaptic transmission involved in urination" RELATED []
is_a: GO:0007274 ! neuromuscular synaptic transmission
relationship: part_of GO:0060073 ! micturition

[Term]
id: GO:0060085
name: smooth muscle relaxation of the bladder outlet
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction in the bladder outlet that contributes to the expulsion of urine from the body." [GOC:dph, PMID:15827347]
synonym: "synaptic transmission involved in urination" EXACT []
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
is_a: GO:0090075 ! relaxation of muscle
relationship: part_of GO:0060073 ! micturition

[Term]
id: GO:0060086
name: circadian temperature homeostasis
namespace: biological_process
def: "Any homeostatic process by which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours." [GOC:dph, GOC:tb]
synonym: "circadian regulation of body temperature" RELATED []
synonym: "circadian thermoregulation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001659 ! temperature homeostasis
is_a: GO:0007623 ! circadian rhythm

[Term]
id: GO:0060087
name: relaxation of vascular smooth muscle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle contraction." [GOC:dph, PMID:15867178]
synonym: "vascular smooth muscle relaxation" EXACT []
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
is_a: GO:0090075 ! relaxation of muscle
relationship: part_of GO:0042311 ! vasodilation

[Term]
id: GO:0060088
name: auditory receptor cell stereocilium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells." [GOC:dph, PMID:10978835]
synonym: "auditory receptor cell stereocilium organisation" EXACT [GOC:curators]
synonym: "auditory receptor cell stereocilium organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0060122 ! inner ear receptor stereocilium organization
relationship: part_of GO:0002093 ! auditory receptor cell morphogenesis

[Term]
id: GO:0060089
name: molecular transducer activity
namespace: molecular_function
def: "The molecular function that accepts an input of one form and creates an output of a different form." [GOC:mtg_MIT_16mar07]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0003674 ! molecular_function

[Term]
id: GO:0060090
name: molecular adaptor activity
namespace: molecular_function
def: "The binding activity of a molecule that brings together two or more molecules, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07]
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0005488 ! binding

[Term]
id: GO:0060091
name: kinocilium
namespace: cellular_component
def: "An immotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia." [GOC:dph, PMID:15882574]
xref: Wikipedia:Kinocilium
is_a: GO:0031513 ! nonmotile primary cilium
is_a: GO:0044422 ! organelle part
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0032421 ! stereocilium bundle

[Term]
id: GO:0060092
name: regulation of synaptic transmission, glycinergic
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph]
is_a: GO:0050804 ! regulation of synaptic transmission
relationship: regulates GO:0060012 ! synaptic transmission, glycinergic

[Term]
id: GO:0060093
name: negative regulation of synaptic transmission, glycinergic
namespace: biological_process
def: "Any process that stops or decreases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph]
synonym: "negative regulation of glycinergic synaptic transmission" EXACT []
is_a: GO:0050805 ! negative regulation of synaptic transmission
is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic
relationship: negatively_regulates GO:0060012 ! synaptic transmission, glycinergic

[Term]
id: GO:0060094
name: positive regulation of synaptic transmission, glycinergic
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph]
synonym: "positive regulation of glycinergic synaptic transmission" EXACT []
is_a: GO:0050806 ! positive regulation of synaptic transmission
is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic
relationship: positively_regulates GO:0060012 ! synaptic transmission, glycinergic

[Term]
id: GO:0060095
name: zinc potentiation of synaptic transmission, glycinergic
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission in the presence of zinc. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph]
synonym: "zinc potentiation of glycinergic synaptic transmission" EXACT []
is_a: GO:0060094 ! positive regulation of synaptic transmission, glycinergic

[Term]
id: GO:0060096
name: serotonin secretion, neurotransmission
namespace: biological_process
def: "The regulated release of serotonin by a cell or group of cells, in which released serotonin acts as a neurotransmitter." [GOC:dph]
is_a: GO:0001820 ! serotonin secretion
is_a: GO:0007269 ! neurotransmitter secretion

[Term]
id: GO:0060097
name: cytoskeletal rearrangement involved in phagocytosis, engulfment
namespace: biological_process
def: "The assembly and arrangement of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph]
is_a: GO:0007010 ! cytoskeleton organization
relationship: part_of GO:0006911 ! phagocytosis, engulfment

[Term]
id: GO:0060098
name: membrane reorganization involved in phagocytosis, engulfment
namespace: biological_process
def: "The assembly and arrangement of the plasma membrane that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph]
is_a: GO:0007009 ! plasma membrane organization
relationship: part_of GO:0006911 ! phagocytosis, engulfment

[Term]
id: GO:0060099
name: regulation of phagocytosis, engulfment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph]
is_a: GO:0050764 ! regulation of phagocytosis
relationship: regulates GO:0006911 ! phagocytosis, engulfment

[Term]
id: GO:0060100
name: positive regulation of phagocytosis, engulfment
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph]
is_a: GO:0050766 ! positive regulation of phagocytosis
is_a: GO:0060099 ! regulation of phagocytosis, engulfment
relationship: positively_regulates GO:0006911 ! phagocytosis, engulfment

[Term]
id: GO:0060101
name: negative regulation of phagocytosis, engulfment
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph]
is_a: GO:0050765 ! negative regulation of phagocytosis
is_a: GO:0060099 ! regulation of phagocytosis, engulfment
relationship: negatively_regulates GO:0006911 ! phagocytosis, engulfment

[Term]
id: GO:0060102
name: collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "collagen and cuticulin-based exoskeleton extracellular matrix" RELATED []
is_a: GO:0005578 ! proteinaceous extracellular matrix

[Term]
id: GO:0060103
name: collagen and cuticulin-based cuticle extracellular matrix part
namespace: cellular_component
def: "Any constituent part of the collagen and cuticulin-based cuticle extracellular matrix, a collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer." [GOC:dph]
is_a: GO:0044420 ! extracellular matrix part

[Term]
id: GO:0060104
name: surface coat of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "An electron dense, amorphous envelope that comprises the outermost layer of the cuticle. The surface coat is loosely apposed to the epicuticle, has distinct biochemical properties, is synthesized by cells other than the underlying hypodermis, and is labile. In addition to serving as a lubricant to protect against abrasion and dehydration, the surface coat may also play important roles in infection and immune evasion. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "surface coat of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED []
is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060105
name: epicuticle of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "A lipid-containing layer of cuticle that lies between the cortical layer and the surface coat. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "epicuticle of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED []
is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060106
name: cortical layer of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "The cuticle layer that lies directly beneath the lipid-containing epicuticle. The cortical layer contains collagens and insoluble, non-collagenous cuticulins and is characterized by a distinct annular pattern consisting of regularly spaced annular ridges delineated by annular furrows. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507]
is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060107
name: annuli extracellular matrix
namespace: cellular_component
def: "The extracellular matrix that is a regularly spaced circumferential ridge present in the cortical region of the cuticle. Annuli are delineated by annular furrows and are present throughout the cuticle with the exception of lateral regions where longitudinal alae are present." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "annulae" RELATED []
synonym: "annular rings" RELATED []
synonym: "annule(s)" RELATED []
synonym: "annulus" RELATED []
is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part
relationship: part_of GO:0060106 ! cortical layer of collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060108
name: annular furrow extracellular matrix
namespace: cellular_component
def: "The extracellular matrix part that is a regularly spaced indentation in the outer cortical layer of the cuticle. The pattern of annular furrows corresponds to sites of invaginations in hypodermal cell membranes that, in turn, correspond to submembranous regions where actin microfilament bundles assemble early in lethargus, the first phase of the molting cycle in which activity and feeding decline." [GOC:dph, GOC:kmv, ISSN:15518507]
is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part
relationship: part_of GO:0060106 ! cortical layer of collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060109
name: medial layer of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "The fluid-filled cuticle layer that lies between the cortical and basal layers and is characterized by the presence of regularly spaced columnar struts that lie on either side of the annular furrows and link the two surrounding layers. In C. elegans, a defined medial layer is found only in adult animals." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "medial layer struts" RELATED []
is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060110
name: basal layer of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "The layer of cuticle most closely apposed to the hypodermal cells. The morphology of the basal layer varies with life stage. In adult C. elegans animals, the basal layers is comprised of three sublayers: two fibrous layers whose fibers run in clockwise and counter-clockwise directions meeting one another at a 60 degree angle, and an amorphous basal layer that lies underneath the fibrous layers and directly contacts the hypodermis. In C. elegans dauer and L1 larval stage animals, the basal layer is characterized by a striated pattern that appears to derive from interwoven laminae. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "basal layer of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED []
is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060111
name: alae of collagen and cuticulin-based cuticle extracellular matrix
namespace: cellular_component
def: "Raised, thickened cuticular ridges that run longitudinally, and in parallel, along the left and right sides of the animal. The alae lie above the hypodermal cells known as the lateral seam cells. In C. elegans, alae are produced in L1 larvae, dauer larvae and adult stage animals, where they consist of three, five, and three ridges of distinct morphology, respectively." [GOC:dph, GOC:kmv, ISSN:15518507]
synonym: "alae of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED []
is_a: GO:0060103 ! collagen and cuticulin-based cuticle extracellular matrix part
relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix

[Term]
id: GO:0060112
name: generation of ovulation cycle rhythm
namespace: biological_process
def: "The process which controls the timing of the type of sexual cycle seen in female mammals." [GOC:dph]
synonym: "generation of estrus cycle rhythm" EXACT []
synonym: "generation of menstrual cycle rhythm" RELATED []
synonym: "generation of oestrus cycle rhythm" EXACT []
is_a: GO:0022602 ! ovulation cycle process

[Term]
id: GO:0060113
name: inner ear receptor cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells, acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound." [GOC:dph]
synonym: "inner ear hair cell differentiation" EXACT []
is_a: GO:0042490 ! mechanoreceptor differentiation
relationship: part_of GO:0048839 ! inner ear development

[Term]
id: GO:0060114
name: vestibular receptor cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a vestibular hair cell." [GOC:dph]
synonym: "vestibular hair cell differentiation" EXACT []
is_a: GO:0060113 ! inner ear receptor cell differentiation

[Term]
id: GO:0060115
name: vestibular receptor cell fate commitment
namespace: biological_process
def: "The process by which a cell becomes committed to become a vestibular receptor cell." [GOC:dph]
synonym: "vestibular hair cell fate commitment" EXACT []
is_a: GO:0060120 ! inner ear receptor cell fate commitment
relationship: part_of GO:0060114 ! vestibular receptor cell differentiation

[Term]
id: GO:0060116
name: vestibular receptor cell morphogenesis
namespace: biological_process
def: "Any process that alters the size or shape of a vestibular receptor cell." [GOC:dph, GOC:tb]
synonym: "vestibular hair cell morphogenesis" EXACT []
is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0060118 ! vestibular receptor cell development

[Term]
id: GO:0060117
name: auditory receptor cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph]
synonym: "auditory hair cell development" EXACT []
is_a: GO:0060119 ! inner ear receptor cell development
relationship: part_of GO:0042491 ! auditory receptor cell differentiation

[Term]
id: GO:0060118
name: vestibular receptor cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph]
synonym: "vestibular hair cell development" EXACT []
is_a: GO:0060119 ! inner ear receptor cell development
relationship: part_of GO:0060114 ! vestibular receptor cell differentiation

[Term]
id: GO:0060119
name: inner ear receptor cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph]
synonym: "inner ear hair cell development" EXACT []
is_a: GO:0048666 ! neuron development
relationship: part_of GO:0060113 ! inner ear receptor cell differentiation

[Term]
id: GO:0060120
name: inner ear receptor cell fate commitment
namespace: biological_process
def: "The process by which a cell becomes committed to become an inner ear receptor cell." [GOC:dph]
synonym: "inner ear hair cell fate commitment" EXACT []
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0060113 ! inner ear receptor cell differentiation

[Term]
id: GO:0060121
name: vestibular receptor cell stereocilium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of vestibular hair cells." [GOC:dph]
synonym: "vestibular hair cell stereocilium organization" EXACT []
synonym: "vestibular receptor cell stereocilium organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0060122 ! inner ear receptor stereocilium organization
relationship: part_of GO:0060116 ! vestibular receptor cell morphogenesis

[Term]
id: GO:0060122
name: inner ear receptor stereocilium organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells." [GOC:dph]
synonym: "inner ear hair cell receptor stereocilium organization" EXACT []
synonym: "inner ear receptor stereocilium organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0030030 ! cell projection organization
relationship: part_of GO:0060119 ! inner ear receptor cell development

[Term]
id: GO:0060123
name: regulation of growth hormone secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell or group of cells." [GOC:dph]
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: regulates GO:0030252 ! growth hormone secretion

[Term]
id: GO:0060124
name: positive regulation of growth hormone secretion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell or group of cells." [GOC:dph]
is_a: GO:0060123 ! regulation of growth hormone secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
relationship: positively_regulates GO:0030252 ! growth hormone secretion

[Term]
id: GO:0060125
name: negative regulation of growth hormone secretion
namespace: biological_process
def: "Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell or group of cells." [GOC:dph]
is_a: GO:0060123 ! regulation of growth hormone secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
relationship: negatively_regulates GO:0030252 ! growth hormone secretion

[Term]
id: GO:0060126
name: somatotropin secreting cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph]
synonym: "growth hormone secreting cell differentiation" EXACT []
synonym: "somatotrope differentiation" RELATED []
synonym: "somatotroph differentiation" RELATED []
synonym: "somatotrophin secreting cell differentiation" EXACT []
synonym: "somatotropic cell differentiation" RELATED []
synonym: "somatrophic cell differentiation" RELATED []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021984 ! adenohypophysis development

[Term]
id: GO:0060127
name: prolactin secreting cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized structural and/or functional features of a prolactin secreting cell. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph]
synonym: "epsilon-acidophil differentiation" EXACT []
synonym: "lactotrope differentiation" EXACT []
synonym: "lactotroph differentiation" EXACT []
synonym: "lactotropic cell differentiation" EXACT []
synonym: "mammotrope differentiation" EXACT []
synonym: "mammotroph differentiation" EXACT []
synonym: "mammotrophic cell differentiation" EXACT []
synonym: "mammotropic cell differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021984 ! adenohypophysis development

[Term]
id: GO:0060128
name: adrenocorticotropin hormone secreting cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized structural and/or functional features of a adrenocorticotropic hormone secreting cell. An adrenocorticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces adrenocorticotropic hormone, or corticotropin." [GOC:dph]
synonym: "adrenocorticotrophic hormone secreting cell differentiation" EXACT []
synonym: "adrenocorticotropic hormone secreting cell differentiation" EXACT [GOC:dph]
synonym: "corticotrope differentiation" EXACT []
synonym: "corticotroph differentiation" EXACT []
synonym: "corticotrophin hormone secreting cell differentiation" RELATED []
synonym: "corticotropin hormone secreting cell differentiation" RELATED []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021984 ! adenohypophysis development

[Term]
id: GO:0060129
name: thyroid stimulating hormone secreting cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized structural and/or functional features of a adrenocorticotropi hormone secreting cell. A thyroid stimulating hormone secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin." [GOC:dph]
synonym: "beta-basophil differentiation" EXACT []
synonym: "thyrotrope differentiation" EXACT []
synonym: "thyrotroph differentiation" EXACT []
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0021984 ! adenohypophysis development

[Term]
id: GO:0060130
name: thyroid stimulating hormone secreting cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a thyroid stimulating hormone secreting cell over time, from its formation to the mature structure. A thyroid stimulating hormone secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin." [GOC:dph]
synonym: "beta-basophil development" EXACT []
synonym: "thyrotrope development" EXACT []
synonym: "thyrotroph development" EXACT []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060129 ! thyroid stimulating hormone secreting cell differentiation

[Term]
id: GO:0060131
name: adrenocorticotropin hormone secreting cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a adrenocorticotropic hormone secreting cell over time, from its formation to the mature structure. An adrenocorticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces adrenocorticotropic hormone, or corticotropin." [GOC:dph]
synonym: "adrenocorticotrophic hormone secreting cell development" EXACT []
synonym: "adrenocorticotropic hormone secreting cell development" EXACT [GOC:dph]
synonym: "corticotrope development" EXACT []
synonym: "corticotroph development" RELATED []
synonym: "corticotrophin hormone secreting cell development" RELATED []
synonym: "corticotropin hormone secreting cell development" RELATED []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060128 ! adrenocorticotropin hormone secreting cell differentiation

[Term]
id: GO:0060132
name: prolactin secreting cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a prolactin secreting cell over time, from its formation to the mature structure. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph]
synonym: "epsilon-acidophil development" EXACT []
synonym: "lactotrope development" EXACT []
synonym: "lactotroph development" EXACT []
synonym: "lactotropic cell development" EXACT []
synonym: "mammotrope development" EXACT []
synonym: "mammotroph development" EXACT []
synonym: "mammotrophic cell development" EXACT []
synonym: "mammotropic cell development" EXACT []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060127 ! prolactin secreting cell differentiation

[Term]
id: GO:0060133
name: somatotropin secreting cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph]
synonym: "growth hormone secreting cell development" EXACT []
synonym: "somatotrope development" RELATED []
synonym: "somatotroph development" RELATED []
synonym: "somatotrophin secreting cell development" EXACT []
synonym: "somatotropic cell development" EXACT []
synonym: "somatrophic cell development" RELATED []
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060126 ! somatotropin secreting cell differentiation

[Term]
id: GO:0060134
name: prepulse inhibition
namespace: biological_process
def: "The process by which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse." [GOC:dph, PMID:10341260]
synonym: "PPI" RELATED []
synonym: "pre-pulse inhibition" EXACT []
xref: Wikipedia:Prepulse_inhibition
is_a: GO:0032102 ! negative regulation of response to external stimulus
relationship: part_of GO:0001964 ! startle response

[Term]
id: GO:0060135
name: maternal process involved in female pregnancy
namespace: biological_process
def: "A reproductive process occurring in the mother that allows an embryo or fetus to develop within it." [GOC:dph]
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0007565 ! female pregnancy

[Term]
id: GO:0060136
name: embryonic process involved in female pregnancy
namespace: biological_process
def: "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother." [GOC:dph]
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0007565 ! female pregnancy
relationship: part_of GO:0009792 ! embryonic development ending in birth or egg hatching

[Term]
id: GO:0060137
name: maternal process involved in parturition
namespace: biological_process
def: "A reproductive process occurring in the mother that results in birth." [GOC:dph]
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0007567 ! parturition

[Term]
id: GO:0060138
name: fetal process involved in parturition
namespace: biological_process
def: "A reproductive process occurring in the embryo that results in birth." [GOC:dph]
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0007567 ! parturition
relationship: part_of GO:0009792 ! embryonic development ending in birth or egg hatching

[Term]
id: GO:0060139
name: positive regulation of apoptosis by virus
namespace: biological_process
def: "Any viral process that activates or increases the frequency, rate or extent of cell death by apoptosis." [GOC:dph]
is_a: GO:0019048 ! virus-host interaction
is_a: GO:0043065 ! positive regulation of apoptosis
relationship: part_of GO:0006926 ! virus-infected cell apoptosis

[Term]
id: GO:0060140
name: syncytium formation by plasma membrane fusion of virally targeted cells
namespace: biological_process
def: "The formation in a cell that has been targeted by a virus of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph]
is_a: GO:0000768 ! syncytium formation by plasma membrane fusion
relationship: part_of GO:0006948 ! induction by virus of host cell-cell fusion

[Term]
id: GO:0060141
name: positive regulation of syncytium formation by virus
namespace: biological_process
def: "The process in which a virus increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph]
is_a: GO:0019054 ! modulation by virus of host cellular process
is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion
relationship: part_of GO:0006948 ! induction by virus of host cell-cell fusion

[Term]
id: GO:0060142
name: regulation of syncytium formation by plasma membrane fusion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0000768 ! syncytium formation by plasma membrane fusion

[Term]
id: GO:0060143
name: positive regulation of syncytium formation by plasma membrane fusion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion
relationship: positively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion

[Term]
id: GO:0060144
name: host cellular processes involved in virus induced gene silencing
namespace: biological_process
def: "The set of cellular processes occurring in the host cell that contribute to the process of posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes." [GOC:dph]
is_a: GO:0009987 ! cellular process
relationship: part_of GO:0009616 ! virus induced gene silencing

[Term]
id: GO:0060145
name: viral gene silencing in virus induced gene silencing
namespace: biological_process
def: "The posttranscriptional gene silencing of viral genes after viral infection." [GOC:dph]
is_a: GO:0016441 ! posttranscriptional gene silencing
relationship: part_of GO:0009616 ! virus induced gene silencing

[Term]
id: GO:0060146
name: host gene silencing in virus induced gene silencing
namespace: biological_process
def: "The posttranscriptional gene silencing of host genes that are homologous to viral genes after viral infection." [GOC:dph]
is_a: GO:0016441 ! posttranscriptional gene silencing
relationship: part_of GO:0009616 ! virus induced gene silencing

[Term]
id: GO:0060147
name: regulation of posttranscriptional gene silencing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph]
is_a: GO:0060968 ! regulation of gene silencing
relationship: regulates GO:0016441 ! posttranscriptional gene silencing

[Term]
id: GO:0060148
name: positive regulation of posttranscriptional gene silencing
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph]
is_a: GO:0045935 ! positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0060147 ! regulation of posttranscriptional gene silencing
relationship: positively_regulates GO:0016441 ! posttranscriptional gene silencing

[Term]
id: GO:0060149
name: negative regulation of posttranscriptional gene silencing
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph]
is_a: GO:0045934 ! negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0060147 ! regulation of posttranscriptional gene silencing
is_a: GO:0060969 ! negative regulation of gene silencing
relationship: negatively_regulates GO:0016441 ! posttranscriptional gene silencing

[Term]
id: GO:0060150
name: viral triggering of virus induced gene silencing
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the inactivation of gene expression of both viral genes and host homologues to those genes by a posttranscriptional mechanism in a virally infected cell." [GOC:dph]
is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing
relationship: part_of GO:0009616 ! virus induced gene silencing

[Term]
id: GO:0060151
name: peroxisome localization
namespace: biological_process
def: "Any process by which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:dph, PMID:16449325]
is_a: GO:0051640 ! organelle localization

[Term]
id: GO:0060152
name: microtubule-based peroxisome localization
namespace: biological_process
def: "The microtubule-based process by which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:dph, PMID:16449325]
is_a: GO:0007017 ! microtubule-based process
is_a: GO:0060151 ! peroxisome localization

[Term]
id: GO:0060153
name: modulation by virus of host cell cycle
namespace: biological_process
def: "Any viral process that modulates the rate or extent of progression through the cell cycle." [GOC:dph]
synonym: "regulation by virus of host cell cycle" EXACT []
synonym: "regulation of host cell cycle by virus" EXACT []
synonym: "viral process regulating host cell cycle" EXACT []
is_a: GO:0019054 ! modulation by virus of host cellular process
is_a: GO:0044071 ! modulation by symbiont of host cell cycle

[Term]
id: GO:0060154
name: cellular process regulating host cell cycle in response to virus
namespace: biological_process
def: "Any cellular process that modulates the rate or extent of progression through the cell cycle in response to a virus." [GOC:dph]
is_a: GO:0009615 ! response to virus
is_a: GO:0051726 ! regulation of cell cycle
relationship: part_of GO:0019055 ! modification by virus of host cell cycle regulation

[Term]
id: GO:0060155
name: platelet dense granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:dph, PMID:11487378]
synonym: "bull's eye body organization and biogenesis" RELATED []
synonym: "platelet dense body organization and biogenesis" RELATED []
synonym: "platelet dense granule organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0033363 ! secretory granule organization

[Term]
id: GO:0060156
name: milk ejection
namespace: biological_process
def: "An automatic response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness." [GOC:dph, GOC:st]
is_a: GO:0060004 ! reflex

[Term]
id: GO:0060157
name: urinary bladder development
namespace: biological_process
def: "The process whose specific outcome is the progression of the urinary bladder over time, from its formation to the mature structure. The urinary bladder is an elastic, muscular sac situated in the anterior part of the pelvic cavity in which urine collects before excretion." [GOC:dph, GOC:ln]
is_a: GO:0048513 ! organ development
relationship: part_of GO:0001655 ! urogenital system development

[Term]
id: GO:0060158
name: activation of phospholipase C activity by dopamine receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:tb, PMID:12675914]
synonym: "activation of phospholipase C activity by dopamine receptor signalling pathway" EXACT [GOC:mah]
synonym: "dopamine receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb]
synonym: "phospholipase C-activating dopamine receptor signaling pathway" EXACT [GOC:dph, GOC:tb]
is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
is_a: GO:0007212 ! dopamine receptor signaling pathway
is_a: GO:0023050 ! consequence of signal transmission

[Term]
id: GO:0060159
name: regulation of dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "regulation of dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
relationship: regulates GO:0007212 ! dopamine receptor signaling pathway

[Term]
id: GO:0060160
name: negative regulation of dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of dopamine receptor protein signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "negative regulation of dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway
relationship: negatively_regulates GO:0007212 ! dopamine receptor signaling pathway

[Term]
id: GO:0060161
name: positive regulation of dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the dopamine receptor protein signaling pathway. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "positive regulation of dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway
relationship: positively_regulates GO:0007212 ! dopamine receptor signaling pathway

[Term]
id: GO:0060162
name: negative regulation of phospholipase C-activating dopamine receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the dopamine receptor, phospholipase C activating pathway." [GOC:dph, GOC:tb, PMID:15016423]
synonym: "negative regulation of dopamine receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of phospholipase C-activating dopamine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0060160 ! negative regulation of dopamine receptor signaling pathway
relationship: negatively_regulates GO:0060158 ! activation of phospholipase C activity by dopamine receptor signaling pathway

[Term]
id: GO:0060163
name: subpallium neuron fate commitment
namespace: biological_process
def: "The process whereby in the subpallium, the developmental fate of a cell becomes restricted such that it will develop into a neuron. The subpallium is the base region of the telencephalon." [GOC:dph]
synonym: "subpallium neuronal precursor fate commitment" RELATED []
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0021544 ! subpallium development

[Term]
id: GO:0060164
name: regulation of timing of neuron differentiation
namespace: biological_process
def: "The process controlling the activation and/or rate at which a relatively unspecialized cell acquires features of a neuron." [GOC:dph]
is_a: GO:0045664 ! regulation of neuron differentiation
is_a: GO:0048505 ! regulation of timing of cell differentiation

[Term]
id: GO:0060165
name: regulation of timing of subpallium neuron differentiation
namespace: biological_process
def: "The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon." [GOC:dph]
is_a: GO:0060164 ! regulation of timing of neuron differentiation
relationship: part_of GO:0021544 ! subpallium development

[Term]
id: GO:0060166
name: olfactory pit development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx." [GOC:dph, ISBN:0124020607]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043584 ! nose development

[Term]
id: GO:0060167
name: regulation of adenosine receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "regulation of adenosine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
relationship: regulates GO:0001973 ! adenosine receptor signaling pathway

[Term]
id: GO:0060168
name: positive regulation of adenosine receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "positive regulation of adenosine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0060167 ! regulation of adenosine receptor signaling pathway
relationship: positively_regulates GO:0001973 ! adenosine receptor signaling pathway

[Term]
id: GO:0060169
name: negative regulation of adenosine receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "negative regulation of adenosine receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0060167 ! regulation of adenosine receptor signaling pathway
relationship: negatively_regulates GO:0001973 ! adenosine receptor signaling pathway

[Term]
id: GO:0060170
name: cilium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a cilium." [GOC:dph, GOC:rph]
is_a: GO:0031253 ! cell projection membrane
is_a: GO:0044441 ! cilium part

[Term]
id: GO:0060171
name: stereocilium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a stereocilium." [GOC:dph, GOC:rph]
is_a: GO:0031528 ! microvillus membrane
is_a: GO:0044422 ! organelle part
is_a: GO:0044424 ! intracellular part
relationship: part_of GO:0032420 ! stereocilium

[Term]
id: GO:0060172
name: spindle astral microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of an astral microtubule. An astral microtubule is any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [GOC:dph]
is_a: GO:0007019 ! microtubule depolymerization
is_a: GO:0030953 ! spindle astral microtubule organization

[Term]
id: GO:0060173
name: limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. For example a leg, arm or some types of fin." [GOC:dgh, GOC:dph, PMID:11487378]
synonym: "limb bud development" NARROW [GOC:dph]
xref: Wikipedia:Limb_development
is_a: GO:0048736 ! appendage development

[Term]
id: GO:0060174
name: limb bud formation
namespace: biological_process
def: "The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable." [GOC:dgh, GOC:dph]
synonym: "limb formation" EXACT []
synonym: "limbbud formation" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0035108 ! limb morphogenesis

[Term]
id: GO:0060175
name: brain-derived neurotrophic factor receptor activity
namespace: molecular_function
def: "Combining with brain-derived neurotrophic factor, to block apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity." [GOC:dph]
synonym: "BDNF receptor activity" RELATED [GOC:dph]
is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity
is_a: GO:0005030 ! neurotrophin receptor activity

[Term]
id: GO:0060176
name: regulation of aggregation involved in sorocarp development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aggregation during sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:dph, GOC:tb]
is_a: GO:0031156 ! regulation of sorocarp development
relationship: regulates GO:0031152 ! aggregation involved in sorocarp development

[Term]
id: GO:0060177
name: regulation of angiotensin metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving angiotensin." [GOC:dph, GOC:tb]
synonym: "regulation of angiotensin metabolism" EXACT []
is_a: GO:0051246 ! regulation of protein metabolic process

[Term]
id: GO:0060178
name: regulation of exocyst localization
namespace: biological_process
def: "Any process that modulates the localization of exocysts. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where secretory vesicles dock and fuse." [GOC:dph, GOC:tb]
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0051601 ! exocyst localization

[Term]
id: GO:0060179
name: male mating behavior
namespace: biological_process
def: "The specific actions or reactions of a male organism that are associated with reproduction." [GOC:dph, GOC:tb]
is_a: GO:0033057 ! reproductive behavior in a multicellular organism
relationship: part_of GO:0007617 ! mating behavior

[Term]
id: GO:0060180
name: female mating behavior
namespace: biological_process
def: "The specific actions or reactions of a female organism that are associated with reproduction." [GOC:dph, GOC:tb]
is_a: GO:0033057 ! reproductive behavior in a multicellular organism
relationship: part_of GO:0007617 ! mating behavior

[Term]
id: GO:0060182
name: apelin receptor activity
namespace: molecular_function
def: "Combining with the peptide apelin to initiate a change in cell activity." [GOC:dph]
is_a: GO:0008528 ! peptide receptor activity, G-protein coupled

[Term]
id: GO:0060183
name: apelin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an apelin receptor binding to one of its physiological ligands." [GOC:dph]
synonym: "apelin receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0060184
name: cell cycle switching
namespace: biological_process
def: "The process by which a cell switches cell cycle mode." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0022402 ! cell cycle process

[Term]
id: GO:0060185
name: outer ear unfolding
namespace: biological_process
def: "The opening and spreading out of the outer ear." [GOC:dph]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0042473 ! outer ear morphogenesis

[Term]
id: GO:0060186
name: outer ear emergence
namespace: biological_process
def: "The growth of the outer ear." [GOC:dph]
synonym: "ear elevation" RELATED [GOC:dph]
synonym: "ear extroversion" RELATED [GOC:dph]
synonym: "outer ear growth" RELATED [GOC:dph]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0042473 ! outer ear morphogenesis

[Term]
id: GO:0060187
name: cell pole
namespace: cellular_component
def: "Either of two different areas at opposite ends of an axis of a cell." [GOC:dph]
is_a: GO:0044464 ! cell part

[Term]
id: GO:0060188
name: regulation of protein desumoylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process by which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb]
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0016926 ! protein desumoylation

[Term]
id: GO:0060189
name: positive regulation of protein desumoylation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process by which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0060188 ! regulation of protein desumoylation
relationship: positively_regulates GO:0016926 ! protein desumoylation

[Term]
id: GO:0060190
name: negative regulation of protein desumoylation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process by which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0060188 ! regulation of protein desumoylation
relationship: negatively_regulates GO:0016926 ! protein desumoylation

[Term]
id: GO:0060191
name: regulation of lipase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:dph, GOC:tb]
subset: gosubset_prok
is_a: GO:0051336 ! regulation of hydrolase activity

[Term]
id: GO:0060192
name: negative regulation of lipase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:dph, GOC:tb]
is_a: GO:0051346 ! negative regulation of hydrolase activity
is_a: GO:0060191 ! regulation of lipase activity

[Term]
id: GO:0060193
name: positive regulation of lipase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051345 ! positive regulation of hydrolase activity
is_a: GO:0060191 ! regulation of lipase activity

[Term]
id: GO:0060194
name: regulation of antisense RNA transcription
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:jp, GOC:tb, PMID:18075583]
is_a: GO:0006355 ! regulation of transcription, DNA-dependent
relationship: regulates GO:0009300 ! antisense RNA transcription

[Term]
id: GO:0060195
name: negative regulation of antisense RNA transcription
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:tb, PMID:18075583]
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent
is_a: GO:0060194 ! regulation of antisense RNA transcription
relationship: negatively_regulates GO:0009300 ! antisense RNA transcription

[Term]
id: GO:0060196
name: positive regulation of antisense RNA transcription
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:tb, PMID:18075583]
is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent
is_a: GO:0060194 ! regulation of antisense RNA transcription
relationship: positively_regulates GO:0009300 ! antisense RNA transcription

[Term]
id: GO:0060197
name: cloacal septation
namespace: biological_process
def: "The separation of the single opening of the digestive, urinary, and reproductive tracts, the cloaca, into multiple isolated openings during development." [GOC:dph, GOC:st]
is_a: GO:0035239 ! tube morphogenesis
relationship: part_of GO:0001655 ! urogenital system development
relationship: part_of GO:0048546 ! digestive tract morphogenesis

[Term]
id: GO:0060198
name: clathrin sculpted vesicle
namespace: cellular_component
def: "A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release." [GOC:dph]
is_a: GO:0030136 ! clathrin-coated vesicle

[Term]
id: GO:0060199
name: clathrin sculpted glutamate transport vesicle
namespace: cellular_component
def: "A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing glutamate." [GOC:dph]
is_a: GO:0030133 ! transport vesicle
is_a: GO:0060198 ! clathrin sculpted vesicle

[Term]
id: GO:0060200
name: clathrin sculpted acetylcholine transport vesicle
namespace: cellular_component
def: "A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing acetylcholine." [GOC:dph]
is_a: GO:0030133 ! transport vesicle
is_a: GO:0060198 ! clathrin sculpted vesicle

[Term]
id: GO:0060201
name: clathrin sculpted acetylcholine transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin sculpted acetylcholine transport vesicle." [GOC:dph]
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030665 ! clathrin coated vesicle membrane
relationship: part_of GO:0060200 ! clathrin sculpted acetylcholine transport vesicle

[Term]
id: GO:0060202
name: clathrin sculpted acetylcholine transport vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the clathrin sculpted acetylcholine transport vesicle." [GOC:dph]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0060200 ! clathrin sculpted acetylcholine transport vesicle

[Term]
id: GO:0060203
name: clathrin sculpted glutamate transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin sculpted glutamate transport vesicle." [GOC:dph]
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030665 ! clathrin coated vesicle membrane
relationship: part_of GO:0060199 ! clathrin sculpted glutamate transport vesicle

[Term]
id: GO:0060204
name: clathrin sculpted glutamate transport vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the clathrin sculpted glutamate transport vesicle." [GOC:dph]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0060199 ! clathrin sculpted glutamate transport vesicle

[Term]
id: GO:0060205
name: cytoplasmic membrane-bounded vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle." [GOC:dph]
synonym: "cytoplasmic membrane-enclosed vesicle lumen" EXACT []
is_a: GO:0031983 ! vesicle lumen
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0016023 ! cytoplasmic membrane-bounded vesicle

[Term]
id: GO:0060206
name: estrous cycle phase
namespace: biological_process
def: "The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur." [GOC:dph]
xref: Wikipedia:Estrous_cycle
is_a: GO:0022602 ! ovulation cycle process

[Term]
id: GO:0060207
name: diestrus
namespace: biological_process
def: "The estrous cycle phase which is a period of sexual quiescence and represents the phase of the mature corpus luteum." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0060206 ! estrous cycle phase

[Term]
id: GO:0060208
name: proestrus
namespace: biological_process
def: "The estrous cycle phase in which there is heightened follicular activity." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0060206 ! estrous cycle phase

[Term]
id: GO:0060209
name: estrus
namespace: biological_process
def: "The estrous cycle phase in which a female is sexually receptive." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "oestrus" EXACT []
is_a: GO:0060206 ! estrous cycle phase

[Term]
id: GO:0060210
name: metestrus
namespace: biological_process
def: "The estrous cycle phase in which there is subsiding follicular function." [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0060206 ! estrous cycle phase

[Term]
id: GO:0060211
name: regulation of nuclear-transcribed mRNA poly(A) tail shortening
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]
synonym: "regulation of 3' to 5' mRNA deadenylation" RELATED []
synonym: "regulation of mRNA deadenylation" RELATED []
synonym: "regulation of nuclear mRNA poly(A) tail shortening" RELATED []
is_a: GO:0031440 ! regulation of mRNA 3'-end processing
is_a: GO:0061013 ! regulation of mRNA catabolic process
relationship: regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening

[Term]
id: GO:0060212
name: negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]
synonym: "negative regulation of 3' to 5' mRNA deadenylation" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of mRNA deadenylation" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of nuclear mRNA poly(A) tail shortening" RELATED []
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0031441 ! negative regulation of mRNA 3'-end processing
is_a: GO:0060211 ! regulation of nuclear-transcribed mRNA poly(A) tail shortening
relationship: negatively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening

[Term]
id: GO:0060213
name: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb]
synonym: "positive regulation of 3' to 5' mRNA deadenylation" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of mRNA deadenylation" RELATED [GOC:dph, GOC:tb]
synonym: "positive regulation of nuclear mRNA poly(A) tail shortening" RELATED []
is_a: GO:0031442 ! positive regulation of mRNA 3'-end processing
is_a: GO:0060211 ! regulation of nuclear-transcribed mRNA poly(A) tail shortening
is_a: GO:0061014 ! positive regulation of mRNA catabolic process
relationship: positively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening

[Term]
id: GO:0060214
name: endocardium formation
namespace: biological_process
def: "Formation of the inner endothelial layer of the heart." [GOC:dph, GOC:rf, PMID:17722983]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003160 ! endocardium morphogenesis

[Term]
id: GO:0060215
name: primitive hemopoiesis
namespace: biological_process
def: "A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells." [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691]
synonym: "primitive haematopoiesis" EXACT []
synonym: "primitive haemopoiesis" EXACT []
synonym: "primitive hematopoiesis" RELATED []
is_a: GO:0035162 ! embryonic hemopoiesis

[Term]
id: GO:0060216
name: definitive hemopoiesis
namespace: biological_process
def: "A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood." [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691]
synonym: "definitive haematopoiesis" RELATED []
synonym: "definitive haemopoiesis" EXACT []
synonym: "definitive hematopoiesis" EXACT []
is_a: GO:0030097 ! hemopoiesis

[Term]
id: GO:0060217
name: hemangioblast cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the characteristics of a mature hemangioblast. Hemangioblasts are the proposed common precursor of blood and endothelial lineages." [GOC:bf, GOC:dph, GOC:ref, PMID:15378083, PMID:9670018]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0060215 ! primitive hemopoiesis

[Term]
id: GO:0060218
name: hemopoietic stem cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a hemopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:bf, GOC:dph, PMID:15378083]
synonym: "haematopoietic stem cell differentiation" EXACT []
synonym: "haemopoietic stem cell differentiation" EXACT []
synonym: "hematopoietic stem cell differentiation" EXACT []
is_a: GO:0048863 ! stem cell differentiation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0060219
name: camera-type eye photoreceptor cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0001754 ! eye photoreceptor cell differentiation
relationship: part_of GO:0003407 ! neural retina development
relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye

[Term]
id: GO:0060220
name: camera-type eye photoreceptor cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell in a camera-type eye." [GOC:dph]
is_a: GO:0042706 ! eye photoreceptor cell fate commitment
relationship: part_of GO:0060219 ! camera-type eye photoreceptor cell differentiation

[Term]
id: GO:0060221
name: retinal rod cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a retinal rod cell." [GOC:dph]
is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation

[Term]
id: GO:0060222
name: regulation of retinal cone cell fate commitment
namespace: biological_process
def: "Any process that modulates the process whereby a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process whereby the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell." [GOC:dph]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
relationship: regulates GO:0046551 ! retinal cone cell fate commitment

[Term]
id: GO:0060223
name: retinal rod cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph]
is_a: GO:0060220 ! camera-type eye photoreceptor cell fate commitment
relationship: part_of GO:0060221 ! retinal rod cell differentiation

[Term]
id: GO:0060224
name: regulation of retinal rod cell fate commitment
namespace: biological_process
def: "Any process that modulates the process whereby the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph]
is_a: GO:0010453 ! regulation of cell fate commitment
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0046532 ! regulation of photoreceptor cell differentiation
relationship: regulates GO:0060223 ! retinal rod cell fate commitment

[Term]
id: GO:0060225
name: positive regulation of retinal rod cell fate commitment
namespace: biological_process
def: "Any process that increases the process whereby the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph]
is_a: GO:0010455 ! positive regulation of cell fate commitment
is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation
is_a: GO:0060224 ! regulation of retinal rod cell fate commitment
relationship: positively_regulates GO:0060223 ! retinal rod cell fate commitment

[Term]
id: GO:0060226
name: negative regulation of retinal cone cell fate commitment
namespace: biological_process
def: "Any process that increases the process whereby a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process whereby the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell." [GOC:dph]
is_a: GO:0010454 ! negative regulation of cell fate commitment
is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation
is_a: GO:0060222 ! regulation of retinal cone cell fate commitment
relationship: negatively_regulates GO:0046551 ! retinal cone cell fate commitment

[Term]
id: GO:0060227
name: Notch signaling pathway involved in camera-type eye photoreceptor fate commitment
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a precursor cell to a eye photoreceptor fate." [GOC:dph]
synonym: "Notch signalling pathway involved in camera-type eye photoreceptor fate commitment" EXACT [GOC:mah]
is_a: GO:0007219 ! Notch signaling pathway
relationship: part_of GO:0060220 ! camera-type eye photoreceptor cell fate commitment

[Term]
id: GO:0060228
name: phosphatidylcholine-sterol O-acyltransferase activator activity
namespace: molecular_function
def: "Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines." [GOC:BHF, GOC:dph, GOC:tb, PMID:4335615]
synonym: "LCAT activator activity" NARROW [GOC:tb]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0060229
name: lipase activator activity
namespace: molecular_function
def: "Increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0008047 ! enzyme activator activity

[Term]
id: GO:0060230
name: lipoprotein lipase activator activity
namespace: molecular_function
def: "Increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein." [GOC:BHF, GOC:dph, GOC:tb, PMID:10727238]
is_a: GO:0060229 ! lipase activator activity

[Term]
id: GO:0060231
name: mesenchymal to epithelial transition
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "mesenchymal-epithelial transition" EXACT [GOC:dph]
is_a: GO:0003382 ! epithelial cell morphogenesis

[Term]
id: GO:0060232
name: delamination
namespace: biological_process
def: "The negative regulation of cell adhesion process by which a cell or sheet of cells splits off of an existing epithelial sheet." [GOC:dph, PMID:16962574, PMID:18343170]
is_a: GO:0022408 ! negative regulation of cell-cell adhesion

[Term]
id: GO:0060233
name: oenocyte delamination
namespace: biological_process
def: "The negative regulation of cell adhesion process by which an oenocyte splits off of an existing epithelial sheet." [GOC:dph]
is_a: GO:0060232 ! delamination

[Term]
id: GO:0060234
name: neuroblast delamination
namespace: biological_process
def: "The negative regulation of cell adhesion process by which a neuroblast slits off of a neurectodermal sheet." [GOC:dph]
is_a: GO:0060232 ! delamination

[Term]
id: GO:0060235
name: lens induction in camera-type eye
namespace: biological_process
def: "Signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens." [GOC:dph, ISBN:0878932437]
is_a: GO:0031128 ! developmental induction
relationship: part_of GO:0002089 ! lens morphogenesis in camera-type eye

[Term]
id: GO:0060236
name: regulation of mitotic spindle organization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of mitotic spindle organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0090224 ! regulation of spindle organization
relationship: regulates GO:0007052 ! mitotic spindle organization

[Term]
id: GO:0060237
name: regulation of fungal-type cell wall organization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GOC:dph, GOC:tb]
synonym: "regulation of fungal-type cell wall organization and biogenesis" RELATED []
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0031505 ! fungal-type cell wall organization

[Term]
id: GO:0060238
name: regulation of signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0031137 ! regulation of conjugation with cellular fusion
relationship: regulates GO:0032005 ! signal transduction involved in conjugation with cellular fusion

[Term]
id: GO:0060239
name: positive regulation of signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion
relationship: positively_regulates GO:0032005 ! signal transduction involved in conjugation with cellular fusion

[Term]
id: GO:0060240
name: negative regulation of signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion
relationship: negatively_regulates GO:0032005 ! signal transduction involved in conjugation with cellular fusion

[Term]
id: GO:0060241
name: lysozyme inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a lysozyme, an enzyme that hydrolyses the beta- (1,4) glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan." [GOC:dph]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0060242
name: contact inhibition
namespace: biological_process
def: "The cellular process by which cells stop growing or dividing in response to increased cell density." [GOC:dph, PMID:17376520]
xref: Wikipedia:Contact_inhibition
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0060243
name: negative regulation of cell growth involved in contact inhibition
namespace: biological_process
def: "The negative regulation of cell growth in response to increased cell density." [GOC:dph]
is_a: GO:0030308 ! negative regulation of cell growth
relationship: part_of GO:0060242 ! contact inhibition

[Term]
id: GO:0060244
name: negative regulation of cell proliferation involved in contact inhibition
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation in response to cell density." [GOC:dph]
is_a: GO:0008285 ! negative regulation of cell proliferation
relationship: part_of GO:0060242 ! contact inhibition

[Term]
id: GO:0060245
name: detection of cell density
namespace: biological_process
def: "The series of events in which information about the density of cells in a population is received and converted into a molecular signal." [GOC:dph]
is_a: GO:0009595 ! detection of biotic stimulus

[Term]
id: GO:0060246
name: detection of cell density by contact stimulus
namespace: biological_process
def: "The series of events in which information about the density of cells in a population is received by direct cell-cell contact and is converted into a molecular signal." [GOC:dph]
is_a: GO:0060245 ! detection of cell density

[Term]
id: GO:0060247
name: detection of cell density by secreted molecule
namespace: biological_process
def: "The series of events in which information about the density of cells in a population is received by the detection of a secreted molecule and is converted into a molecular signal." [GOC:dph]
is_a: GO:0060245 ! detection of cell density

[Term]
id: GO:0060248
name: detection of cell density by contact stimulus involved in contact inhibition
namespace: biological_process
def: "The series of events in which information about the density of cells in a population is received by direct cell-cell contact and is converted into a molecular signal, resulting in the cessation of cell growth or proliferation." [GOC:dph]
is_a: GO:0060246 ! detection of cell density by contact stimulus
relationship: part_of GO:0060242 ! contact inhibition

[Term]
id: GO:0060249
name: anatomical structure homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal equilibrium within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph]
synonym: "anatomical structure maintenance" EXACT [GOC:dph]
is_a: GO:0042592 ! homeostatic process

[Term]
id: GO:0060250
name: germ-line stem-cell niche homeostasis
namespace: biological_process
def: "A homeostatic process involved in the maintenance of an internal equilibrium within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion." [GOC:dph]
synonym: "germ-line stem-cell niche maintenance" EXACT [GOC:dph, GOC:tb]
synonym: "maintenance of germ line stem cell niche" EXACT [GOC:dph]
synonym: "maintenance of germ line stem-cell niche" EXACT [GOC:dph]
synonym: "maintenance of germ-line stem cell niche" EXACT [GOC:dph]
synonym: "maintenance of germ-line stem-cell niche" EXACT [GOC:dph]
is_a: GO:0060249 ! anatomical structure homeostasis

[Term]
id: GO:0060251
name: regulation of glial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glial cell proliferation." [GOC:dph, GOC:tb]
is_a: GO:0014013 ! regulation of gliogenesis
is_a: GO:0042127 ! regulation of cell proliferation
relationship: regulates GO:0014009 ! glial cell proliferation

[Term]
id: GO:0060252
name: positive regulation of glial cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0014015 ! positive regulation of gliogenesis
is_a: GO:0060251 ! regulation of glial cell proliferation
relationship: positively_regulates GO:0014009 ! glial cell proliferation

[Term]
id: GO:0060253
name: negative regulation of glial cell proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0014014 ! negative regulation of gliogenesis
is_a: GO:0060251 ! regulation of glial cell proliferation
relationship: negatively_regulates GO:0014009 ! glial cell proliferation

[Term]
id: GO:0060254
name: regulation of N-terminal protein palmitoylation
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of the covalent or non-covalent attachment of a palmitoyl moiety to the N-terminal amino acid residue of a protein." [GOC:dph, GOC:tb]
is_a: GO:0010556 ! regulation of macromolecule biosynthetic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0031399 ! regulation of protein modification process
is_a: GO:0050746 ! regulation of lipoprotein metabolic process
relationship: regulates GO:0006500 ! N-terminal protein palmitoylation

[Term]
id: GO:0060255
name: regulation of macromolecule metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb]
subset: gosubset_prok
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0043170 ! macromolecule metabolic process

[Term]
id: GO:0060256
name: regulation of flocculation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the non-sexual aggregation of single-celled organisms." [GOC:dph, GOC:tb]
is_a: GO:0043900 ! regulation of multi-organism process
relationship: regulates GO:0000128 ! flocculation

[Term]
id: GO:0060257
name: negative regulation of flocculation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the non-sexual aggregation of single-celled organisms." [GOC:dph, GOC:tb]
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0060256 ! regulation of flocculation
relationship: negatively_regulates GO:0000128 ! flocculation

[Term]
id: GO:0060258
name: negative regulation of filamentous growth
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the process by which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:tb]
is_a: GO:0010570 ! regulation of filamentous growth
is_a: GO:0045926 ! negative regulation of growth
relationship: negatively_regulates GO:0030447 ! filamentous growth

[Term]
id: GO:0060259
name: regulation of feeding behavior
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of feeding behaviour" EXACT [GOC:dph, GOC:tb]
is_a: GO:0050795 ! regulation of behavior
relationship: regulates GO:0007631 ! feeding behavior

[Term]
id: GO:0060260
name: regulation of transcription initiation from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a process involved in starting transcription from the RNA polymerase II promoter." [GOC:dph, GOC:tb]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0043254 ! regulation of protein complex assembly
relationship: regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter

[Term]
id: GO:0060261
name: positive regulation of transcription initiation from RNA polymerase II promoter
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a process involved in starting transcription from the RNA polymerase II promoter." [GOC:dph, GOC:tb]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter
relationship: positively_regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter

[Term]
id: GO:0060262
name: negative regulation of N-terminal protein palmitoylation
namespace: biological_process
def: "Any process that decreases the rate frequency or extent of the covalent or non-covalent attachment of a palmitoyl moiety to the N-terminal amino acid residue of a protein." [GOC:dph, GOC:tb]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0050748 ! negative regulation of lipoprotein metabolic process
is_a: GO:0060254 ! regulation of N-terminal protein palmitoylation
relationship: negatively_regulates GO:0006500 ! N-terminal protein palmitoylation

[Term]
id: GO:0060263
name: regulation of respiratory burst
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0045730 ! respiratory burst

[Term]
id: GO:0060264
name: regulation of respiratory burst during acute inflammatory response
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0002673 ! regulation of acute inflammatory response
is_a: GO:0002697 ! regulation of immune effector process
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0060263 ! regulation of respiratory burst
relationship: regulates GO:0002536 ! respiratory burst during acute inflammatory response

[Term]
id: GO:0060265
name: positive regulation of respiratory burst during acute inflammatory response
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002675 ! positive regulation of acute inflammatory response
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0045089 ! positive regulation of innate immune response
is_a: GO:0060264 ! regulation of respiratory burst during acute inflammatory response
is_a: GO:0060267 ! positive regulation of respiratory burst
relationship: positively_regulates GO:0002536 ! respiratory burst during acute inflammatory response

[Term]
id: GO:0060266
name: negative regulation of respiratory burst during acute inflammatory response
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0002674 ! negative regulation of acute inflammatory response
is_a: GO:0002698 ! negative regulation of immune effector process
is_a: GO:0045824 ! negative regulation of innate immune response
is_a: GO:0060264 ! regulation of respiratory burst during acute inflammatory response
is_a: GO:0060268 ! negative regulation of respiratory burst
relationship: negatively_regulates GO:0002536 ! respiratory burst during acute inflammatory response

[Term]
id: GO:0060267
name: positive regulation of respiratory burst
namespace: biological_process
def: "Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb]
is_a: GO:0009893 ! positive regulation of metabolic process
is_a: GO:0060263 ! regulation of respiratory burst
relationship: positively_regulates GO:0045730 ! respiratory burst

[Term]
id: GO:0060268
name: negative regulation of respiratory burst
namespace: biological_process
def: "Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb]
is_a: GO:0009892 ! negative regulation of metabolic process
is_a: GO:0060263 ! regulation of respiratory burst
relationship: negatively_regulates GO:0045730 ! respiratory burst

[Term]
id: GO:0060269
name: centripetally migrating follicle cell migration
namespace: biological_process
def: "The cell migration process in which a follicle cell migrates as part of an epithelial sheet between the nurse cells and the oocyte. At the end of migration, they cover the anterior of the oocyte." [GOC:dph]
is_a: GO:0007297 ! ovarian follicle cell migration

[Term]
id: GO:0060270
name: main body follicle cell migration
namespace: biological_process
def: "The ovarian follicle cell migration process in which follicle cells migrate posteeriorly to form a columnar epithelium over the oocyte." [GOC:dph]
is_a: GO:0007297 ! ovarian follicle cell migration

[Term]
id: GO:0060271
name: cilium morphogenesis
namespace: biological_process
def: "A process that is carried out at the cellular level and by which the structure of a cilium is organized. Morphogenesis pertains to the creation of form." [GOC:BHF, GOC:dph]
synonym: "cilium organization" RELATED [GOC:dph]
is_a: GO:0048858 ! cell projection morphogenesis

[Term]
id: GO:0060272
name: embryonic skeletal joint morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A joint is the connecting structure between the bones of the skeleton. Morphogenesis pertains to the creation of form." [GOC:BHF, GOC:dph]
is_a: GO:0048704 ! embryonic skeletal system morphogenesis

[Term]
id: GO:0060273
name: crying behavior
namespace: biological_process
def: "The behavior in which an organism sheds tears, often accompanied by non-verbal vocalizations and in response to external or internal stimuli." [GOC:dph]
is_a: GO:0007610 ! behavior

[Term]
id: GO:0060274
name: maintenance of stationary phase
namespace: biological_process
def: "The homeostatic process by which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction. Stationary phase can be in response to limited nutrientsor a build-up of toxic substances in the environment." [GOC:dph]
is_a: GO:0048874 ! homeostasis of number of cells in a free-living population

[Term]
id: GO:0060275
name: maintenance of stationary phase in response to starvation
namespace: biological_process
def: "The homeostatic process by which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to limited nutrients in the environment." [GOC:dph]
is_a: GO:0042594 ! response to starvation
is_a: GO:0060274 ! maintenance of stationary phase

[Term]
id: GO:0060276
name: maintenance of stationary phase in response to toxin
namespace: biological_process
def: "The homeostatic process by which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to a build-up of toxins in the environment." [GOC:dph]
is_a: GO:0009636 ! response to toxin
is_a: GO:0060274 ! maintenance of stationary phase

[Term]
id: GO:0060277
name: negative regulation of transcription involved in G1 phase of mitotic cell cycle
namespace: biological_process
def: "Any process that stop, prevents or decreases transcription as part of the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:tb]
synonym: "negative regulation of transcription from RNA polymerase II promoter during G1 phase of mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
is_a: GO:0000114 ! regulation of transcription involved in G1 phase of mitotic cell cycle
is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter

[Term]
id: GO:0060278
name: regulation of ovulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0030728 ! ovulation

[Term]
id: GO:0060279
name: positive regulation of ovulation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0060278 ! regulation of ovulation
relationship: positively_regulates GO:0030728 ! ovulation

[Term]
id: GO:0060280
name: negative regulation of ovulation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0060278 ! regulation of ovulation
relationship: negatively_regulates GO:0030728 ! ovulation

[Term]
id: GO:0060281
name: regulation of oocyte development
namespace: biological_process
def: "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb, PMID:2394318]
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0048599 ! oocyte development

[Term]
id: GO:0060282
name: positive regulation of oocyte development
namespace: biological_process
def: "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0060281 ! regulation of oocyte development
relationship: positively_regulates GO:0048599 ! oocyte development

[Term]
id: GO:0060283
name: negative regulation of oocyte development
namespace: biological_process
def: "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0060281 ! regulation of oocyte development
relationship: negatively_regulates GO:0048599 ! oocyte development

[Term]
id: GO:0060284
name: regulation of cell development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: regulates GO:0048468 ! cell development

[Term]
id: GO:0060285
name: ciliary cell motility
namespace: biological_process
def: "Cell motility due to the motion of one or more cilia." [GOC:dgh, GOC:dph, GOC:mlg]
is_a: GO:0001539 ! ciliary or flagellar motility

[Term]
id: GO:0060286
name: flagellar cell motility
namespace: biological_process
def: "Cell motility due to the motion of one or more flagellum." [GOC:dgh, GOC:dph, GOC:mlg]
is_a: GO:0001539 ! ciliary or flagellar motility

[Term]
id: GO:0060287
name: cilium movement involved in determination of left/right asymmetry
namespace: biological_process
def: "The movement of cilia of epithelial cells resulting in the transport of signals which determine asymmetry in an organism's body plan with respect to the left and right halves." [GOC:dgh, GOC:dph, GOC:mlg]
synonym: "cilium movement involved in determinationof L/R asymmetry" EXACT []
is_a: GO:0003351 ! epithelial cilium movement
relationship: part_of GO:0007368 ! determination of left/right symmetry

[Term]
id: GO:0060288
name: formation of a compartment boundary
namespace: biological_process
def: "Formation of a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph]
synonym: " compartment boundary formation" EXACT []
is_a: GO:0048859 ! formation of anatomical boundary
relationship: part_of GO:0007386 ! compartment pattern formation

[Term]
id: GO:0060289
name: compartment boundary maintenance
namespace: biological_process
def: "A homeostatic process involved in the maintenance of a compartment boundary. A compartment boundary is a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph]
is_a: GO:0001894 ! tissue homeostasis
relationship: part_of GO:0007386 ! compartment pattern formation

[Term]
id: GO:0060290
name: transdifferentiation
namespace: biological_process
def: "The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate." [GOC:dph, GOC:kmv]
xref: Wikipedia:Transdifferentiation
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0060291
name: long-term synaptic potentiation
namespace: biological_process
def: "A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph]
synonym: "long-term potentiation" BROAD [GOC:dph]
synonym: "LTP" RELATED [GOC:dph]
is_a: GO:0048167 ! regulation of synaptic plasticity
is_a: GO:0050806 ! positive regulation of synaptic transmission

[Term]
id: GO:0060292
name: long term synaptic depression
namespace: biological_process
def: "A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph]
synonym: "long term depression" BROAD [GOC:dph]
synonym: "LTD" RELATED [GOC:dph]
is_a: GO:0048167 ! regulation of synaptic plasticity
is_a: GO:0050805 ! negative regulation of synaptic transmission

[Term]
id: GO:0060293
name: germ plasm
namespace: cellular_component
def: "Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line." [GOC:dph]
xref: Wikipedia:Germ_plasm
is_a: GO:0045495 ! pole plasm

[Term]
id: GO:0060294
name: cilium movement involved in cell motility
namespace: biological_process
def: "Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0003341 ! cilium movement
relationship: part_of GO:0060285 ! ciliary cell motility

[Term]
id: GO:0060295
name: regulation of cilium movement involved in cell motility
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0003352 ! regulation of cilium movement
is_a: GO:0040012 ! regulation of locomotion
relationship: regulates GO:0060294 ! cilium movement involved in cell motility

[Term]
id: GO:0060296
name: regulation of cilium beat frequency involved in ciliary motility
namespace: biological_process
def: "Any process that modulates the frequency of cilium beating involved in ciliary motility." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0060295 ! regulation of cilium movement involved in cell motility
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0060297
name: regulation of sarcomere organization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0045214 ! sarcomere organization

[Term]
id: GO:0060298
name: positive regulation of sarcomere organization
namespace: biological_process
def: "Any process that increases the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
is_a: GO:0060297 ! regulation of sarcomere organization
relationship: positively_regulates GO:0045214 ! sarcomere organization

[Term]
id: GO:0060299
name: negative regulation of sarcomere organization
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:0060297 ! regulation of sarcomere organization
relationship: negatively_regulates GO:0045214 ! sarcomere organization

[Term]
id: GO:0060300
name: regulation of cytokine activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0043393 ! regulation of protein binding

[Term]
id: GO:0060301
name: positive regulation of cytokine activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:0060300 ! regulation of cytokine activity

[Term]
id: GO:0060302
name: negative regulation of cytokine activity
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:0060300 ! regulation of cytokine activity

[Term]
id: GO:0060303
name: regulation of nucleosome density
namespace: biological_process
def: "Any process that modulates the number of nucleosomes in a given region of a chromosome." [GOC:dph, GOC:tb]
is_a: GO:0034728 ! nucleosome organization
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0060304
name: regulation of phosphoinositide dephosphorylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reaction involving the removal of one or more phosphate groups from a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives." [GOC:dph, GOC:tb]
is_a: GO:0019216 ! regulation of lipid metabolic process
is_a: GO:0035303 ! regulation of dephosphorylation
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0046856 ! phosphoinositide dephosphorylation

[Term]
id: GO:0060305
name: regulation of cell diameter
namespace: biological_process
def: "Any process that modulates the diameter of a cell, the length of a line segment that crosses through the center of a circular section through a cell." [GOC:dph, GOC:tb]
synonym: "regulation of cell width" BROAD [GOC:dph, GOC:tb]
is_a: GO:0008361 ! regulation of cell size

[Term]
id: GO:0060306
name: regulation of membrane repolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0042391 ! regulation of membrane potential

[Term]
id: GO:0060307
name: regulation of ventricular cardiomyocyte membrane repolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "electrocardiogram T wave" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of ventricular cardiac muscle cell repolarization" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of ventricular cardiac muscle repolarization" RELATED [GOC:dph, GOC:tb]
synonym: "ventricular repolarization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0055117 ! regulation of cardiac muscle contraction
is_a: GO:0060306 ! regulation of membrane repolarization

[Term]
id: GO:0060308
name: GTP cyclohydrolase I regulator activity
namespace: molecular_function
def: "Modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate." [GOC:dph, GOC:tb]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0060309
name: elastin catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of elastin. Elastin is a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "elastin breakdown" EXACT []
synonym: "elastin catabolism" EXACT []
synonym: "elastin degradation" EXACT []
is_a: GO:0006516 ! glycoprotein catabolic process
is_a: GO:0051541 ! elastin metabolic process

[Term]
id: GO:0060310
name: regulation of elastin catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "regulation of elastin breakdown" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of elastin catabolism" EXACT [GOC:dph, GOC:tb]
synonym: "regulation of elastin degradation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process
relationship: regulates GO:0060309 ! elastin catabolic process

[Term]
id: GO:0060311
name: negative regulation of elastin catabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down-regulation of elastin catabolic process" EXACT []
synonym: "negative regulation of elastin breakdown" EXACT []
synonym: "negative regulation of elastin catabolism" EXACT []
synonym: "negative regulation of elastin degradation" EXACT []
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0031330 ! negative regulation of cellular catabolic process
is_a: GO:0060310 ! regulation of elastin catabolic process
relationship: negatively_regulates GO:0060309 ! elastin catabolic process

[Term]
id: GO:0060312
name: regulation of blood vessel remodeling
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0034103 ! regulation of tissue remodeling
relationship: regulates GO:0001974 ! blood vessel remodeling

[Term]
id: GO:0060313
name: negative regulation of blood vessel remodeling
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "down-regulation of blood vessel remodeling" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of blood vessel remodeling" NARROW [GOC:dph, GOC:tb]
is_a: GO:0034104 ! negative regulation of tissue remodeling
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0060312 ! regulation of blood vessel remodeling
relationship: negatively_regulates GO:0001974 ! blood vessel remodeling

[Term]
id: GO:0060314
name: regulation of ryanodine-sensitive calcium-release channel activity
namespace: biological_process
def: "Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032412 ! regulation of ion transmembrane transporter activity
is_a: GO:0051924 ! regulation of calcium ion transport

[Term]
id: GO:0060315
name: negative regulation of ryanodine-sensitive calcium-release channel activity
namespace: biological_process
def: "Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity
is_a: GO:0060314 ! regulation of ryanodine-sensitive calcium-release channel activity

[Term]
id: GO:0060316
name: positive regulation of ryanodine-sensitive calcium-release channel activity
namespace: biological_process
def: "Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity
is_a: GO:0060314 ! regulation of ryanodine-sensitive calcium-release channel activity

[Term]
id: GO:0060317
name: cardiac epithelial to mesenchymal transition
namespace: biological_process
def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, PMID:16314491, PMID:1996351]
synonym: "heart epithelial to mesenchymal transition" EXACT []
is_a: GO:0001837 ! epithelial to mesenchymal transition
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0060318
name: definitive erythrocyte differentiation
namespace: biological_process
def: "Erythrocyte differentiation which occurs as part of the process of definitive hemopoiesis." [GOC:add, GOC:BHF, GOC:dph]
synonym: "definitive erythropoiesis" EXACT []
synonym: "definitive RBC differentiation" EXACT [CL:0000232]
synonym: "definitive red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0030218 ! erythrocyte differentiation
relationship: part_of GO:0060216 ! definitive hemopoiesis

[Term]
id: GO:0060319
name: primitive erythrocyte differentiation
namespace: biological_process
def: "Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis." [GOC:adiehl, GOC:BHF, GOC:dph]
synonym: "primitive erythropoiesis" EXACT [GOC:adiehl, GOC:dph]
synonym: "primitive RBC differentiation" EXACT [CL:0000232]
synonym: "primitive red blood cell differentiation" EXACT [CL:0000232]
is_a: GO:0030218 ! erythrocyte differentiation
relationship: part_of GO:0060215 ! primitive hemopoiesis

[Term]
id: GO:0060320
name: rejection of self pollen
namespace: biological_process
def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the rejection of the self pollen by cells in the stigma." [GOC:dph, GOC:tb]
is_a: GO:0048544 ! recognition of pollen

[Term]
id: GO:0060321
name: acceptance of pollen
namespace: biological_process
def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the acceptance of pollen by cells in the stigma." [GOC:dph, GOC:tb]
synonym: "acceptance of non-self pollen" RELATED [GOC:dph, GOC:tb]
synonym: "acceptance of self pollen" NARROW [GOC:dph, GOC:tb]
is_a: GO:0048544 ! recognition of pollen

[Term]
id: GO:0060322
name: head development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0060323
name: head morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0010171 ! body morphogenesis
relationship: part_of GO:0060322 ! head development

[Term]
id: GO:0060324
name: face development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060322 ! head development

[Term]
id: GO:0060325
name: face morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the face are generated and organized. The face is the ventral division of the head." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060323 ! head morphogenesis
relationship: part_of GO:0060324 ! face development

[Term]
id: GO:0060326
name: cell chemotaxis
namespace: biological_process
def: "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph]
is_a: GO:0006935 ! chemotaxis
is_a: GO:0048870 ! cell motility
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0060327
name: cytoplasmic actin-based contraction involved in cell motility
namespace: biological_process
def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell from one place to another." [GOC:dph]
is_a: GO:0030048 ! actin filament-based movement
is_a: GO:0070252 ! actin-mediated cell contraction
relationship: part_of GO:0048870 ! cell motility

[Term]
id: GO:0060328
name: cytoplasmic actin-based contraction involved in forward cell motility
namespace: biological_process
def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the front of the cell." [GOC:dph]
synonym: "cytoplasmic actin-based contraction involved in forward cell locomotion" RELATED []
is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility

[Term]
id: GO:0060329
name: cytoplasmic actin-based contraction involved in rearward cell motility
namespace: biological_process
def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the rear of the cell." [GOC:dph]
synonym: "cytoplasmic actin-based contraction involved in rearward cell locomotion" RELATED []
is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility

[Term]
id: GO:0060330
name: regulation of response to interferon-gamma
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph]
synonym: "regulation of response to gamma-interferon" RELATED []
synonym: "regulation of response to immune interferon" EXACT []
synonym: "regulation of response to type II IFN" EXACT []
synonym: "regulation of response to type II interferon" EXACT []
is_a: GO:0045088 ! regulation of innate immune response
is_a: GO:0060759 ! regulation of response to cytokine stimulus
relationship: regulates GO:0034341 ! response to interferon-gamma

[Term]
id: GO:0060331
name: negative regulation of response to interferon-gamma
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph]
synonym: "negative regulation of response to gamma-interferon" RELATED []
synonym: "negative regulation of response to immune interferon" EXACT []
synonym: "negative regulation of response to type II IFN" EXACT []
synonym: "negative regulation of response to type II interferon" EXACT []
is_a: GO:0060330 ! regulation of response to interferon-gamma
is_a: GO:0060761 ! negative regulation of response to cytokine stimulus
relationship: negatively_regulates GO:0034341 ! response to interferon-gamma

[Term]
id: GO:0060332
name: positive regulation of response to interferon-gamma
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph]
synonym: "positive regulation of response to gamma-interferon" RELATED []
synonym: "positive regulation of response to immune interferon" EXACT []
synonym: "positive regulation of response to type II IFN" EXACT []
synonym: "positive regulation of response to type II interferon" EXACT []
is_a: GO:0060330 ! regulation of response to interferon-gamma
is_a: GO:0060760 ! positive regulation of response to cytokine stimulus
relationship: positively_regulates GO:0034341 ! response to interferon-gamma

[Term]
id: GO:0060333
name: interferon-gamma-mediated signaling pathway
namespace: biological_process
def: "A series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:add, GOC:dph]
synonym: "gamma-interferon-mediated signaling pathway" EXACT [GOC:dph]
synonym: "immune interferon signaling pathway" EXACT [GOC:dph]
synonym: "interferon-gamma-mediated signalling pathway" EXACT [GOC:mah]
synonym: "type II IFN-mediated signaling pathway" RELATED []
synonym: "type II interferon-mediated signaling pathway" EXACT [GOC:dph]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0060334
name: regulation of interferon-gamma-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph]
synonym: "regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph]
synonym: "regulation of immune interferon signaling pathway" EXACT [GOC:dph]
synonym: "regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah]
synonym: "regulation of type II IFN-mediated signaling pathway" EXACT [GOC:dph]
synonym: "regulation of type II interferon-mediated signaling pathway" EXACT [GOC:dph]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0060333 ! interferon-gamma-mediated signaling pathway

[Term]
id: GO:0060335
name: positive regulation of interferon-gamma-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph]
synonym: "positive regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph]
synonym: "positive regulation of immune interferon-mediated signaling pathway" EXACT [GOC:dph]
synonym: "positive regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of type II IFN-mediated pathway" EXACT [GOC:dph]
synonym: "positive regulation of type II interferon-mediated signaling pathway" EXACT [GOC:dph]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0060334 ! regulation of interferon-gamma-mediated signaling pathway
relationship: positively_regulates GO:0060333 ! interferon-gamma-mediated signaling pathway

[Term]
id: GO:0060336
name: negative regulation of interferon-gamma-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph]
synonym: "negative regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph]
synonym: "negative regulation of immune interferon-mediated signaling pathway" EXACT [GOC:dph]
synonym: "negative regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of type II IFN-mediated signaling pathway" EXACT [GOC:dph]
synonym: "negative regulation of type II interferon-mediated signaling pathway" EXACT [GOC:dph]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0060334 ! regulation of interferon-gamma-mediated signaling pathway
relationship: negatively_regulates GO:0060333 ! interferon-gamma-mediated signaling pathway

[Term]
id: GO:0060337
name: type I interferon-mediated signaling pathway
namespace: biological_process
def: "A series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:dph]
synonym: "type I interferon-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0060338
name: regulation of type I interferon-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph]
synonym: "regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0060337 ! type I interferon-mediated signaling pathway

[Term]
id: GO:0060339
name: negative regulation of type I interferon-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph]
synonym: "negative regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0060338 ! regulation of type I interferon-mediated signaling pathway
relationship: negatively_regulates GO:0060337 ! type I interferon-mediated signaling pathway

[Term]
id: GO:0060340
name: positive regulation of type I interferon-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph]
synonym: "positive regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0060338 ! regulation of type I interferon-mediated signaling pathway
relationship: positively_regulates GO:0060337 ! type I interferon-mediated signaling pathway

[Term]
id: GO:0060341
name: regulation of cellular localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a process by which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb]
is_a: GO:0032879 ! regulation of localization
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0051641 ! cellular localization

[Term]
id: GO:0060342
name: photoreceptor inner segment membrane
namespace: cellular_component
def: "The membrane surrounding the outer segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:dph]
is_a: GO:0016020 ! membrane
relationship: part_of GO:0001917 ! photoreceptor inner segment

[Term]
id: GO:0060343
name: trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph]
synonym: "trabecula biogenesis" RELATED [GOC:dph]
synonym: "trabeculation" EXACT [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0009887 ! organ morphogenesis

[Term]
id: GO:0060344
name: liver trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph]
synonym: "liver trabecula biogenesis" RELATED []
synonym: "liver trabeculation" EXACT [GOC:dph]
is_a: GO:0060343 ! trabecula formation
relationship: part_of GO:0001889 ! liver development

[Term]
id: GO:0060345
name: spleen trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph]
synonym: "spleen trabecula biogenesis" RELATED [GOC:dph]
synonym: "spleen trabeculation" EXACT [GOC:dph]
is_a: GO:0060343 ! trabecula formation
relationship: part_of GO:0048536 ! spleen development

[Term]
id: GO:0060346
name: bone trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph]
synonym: "bone trabecula biogenesis" RELATED [GOC:dph]
synonym: "bone trabeculation" EXACT [GOC:dph]
synonym: "skeletal trabecula biogenesis" RELATED [GOC:dph]
synonym: "skeletal trabecula formation" EXACT [GOC:dph]
synonym: "skeletal trabeculation" EXACT [GOC:dph]
is_a: GO:0060343 ! trabecula formation
relationship: part_of GO:0048705 ! skeletal system morphogenesis

[Term]
id: GO:0060347
name: heart trabecula formation
namespace: biological_process
def: "The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph]
synonym: "cardiac trabecula formation" EXACT [GOC:dph]
synonym: "cardiac trabeculation" EXACT [GOC:dph]
synonym: "heart trabecula biogenesis" RELATED [GOC:dph]
synonym: "heart trabeculation" EXACT [GOC:dph]
is_a: GO:0060343 ! trabecula formation
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis

[Term]
id: GO:0060348
name: bone development
namespace: biological_process
def: "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001501 ! skeletal system development

[Term]
id: GO:0060349
name: bone morphogenesis
namespace: biological_process
def: "The process by which bones are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0048705 ! skeletal system morphogenesis
relationship: part_of GO:0060348 ! bone development

[Term]
id: GO:0060350
name: endochondral bone morphogenesis
namespace: biological_process
def: "The process by which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone." [GOC:dph, PMID:11680679]
is_a: GO:0060349 ! bone morphogenesis

[Term]
id: GO:0060351
name: cartilage development involved in endochondral bone morphogenesis
namespace: biological_process
def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones." [GOC:dph]
is_a: GO:0051216 ! cartilage development
relationship: part_of GO:0060350 ! endochondral bone morphogenesis

[Term]
id: GO:0060352
name: cell adhesion molecule production
namespace: biological_process
def: "The appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl]
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0060353
name: regulation of cell adhesion molecule production
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0060352 ! cell adhesion molecule production

[Term]
id: GO:0060354
name: negative regulation of cell adhesion molecule production
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0060353 ! regulation of cell adhesion molecule production
relationship: negatively_regulates GO:0060352 ! cell adhesion molecule production

[Term]
id: GO:0060355
name: positive regulation of cell adhesion molecule production
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0060353 ! regulation of cell adhesion molecule production
relationship: positively_regulates GO:0060352 ! cell adhesion molecule production

[Term]
id: GO:0060356
name: leucine import
namespace: biological_process
def: "The directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb]
synonym: "L-leucine import" NARROW []
synonym: "L-leucine uptake" NARROW []
synonym: "leucine uptake" EXACT []
is_a: GO:0015820 ! leucine transport

[Term]
id: GO:0060357
name: regulation of leucine import
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb]
synonym: "regulation of L-leucine import" NARROW [GOC:dph, GOC:tb]
synonym: "regulation of L-leucine uptake" NARROW [GOC:dph, GOC:tb]
synonym: "regulation of leucine uptake" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010958 ! regulation of amino acid import
relationship: regulates GO:0060356 ! leucine import

[Term]
id: GO:0060358
name: negative regulation of leucine import
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb]
is_a: GO:0051956 ! negative regulation of amino acid transport
is_a: GO:0060357 ! regulation of leucine import
relationship: negatively_regulates GO:0060356 ! leucine import

[Term]
id: GO:0060359
name: response to ammonium ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus." [GOC:dph, GOC:tb]
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0060360
name: negative regulation of leucine import in response to ammonium ion
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of leucine import as a result of an ammonium ion stimulus. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb]
synonym: "negative regulation of leucine uptake in response to ammonium ion" EXACT []
is_a: GO:0060358 ! negative regulation of leucine import
is_a: GO:0071242 ! cellular response to ammonium ion

[Term]
id: GO:0060361
name: flight
namespace: biological_process
def: "Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph]
is_a: GO:0040011 ! locomotion

[Term]
id: GO:0060362
name: flight involved in flight behavior
namespace: biological_process
def: "Self-propelled movement of an organism from one location to another through the air that is part of the organism's response to external or internal stimuli resulting in flight." [GOC:dph]
is_a: GO:0060361 ! flight
relationship: part_of GO:0007629 ! flight behavior

[Term]
id: GO:0060363
name: cranial suture morphogenesis
namespace: biological_process
def: "The process by which the cranial suture is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:sl]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060349 ! bone morphogenesis

[Term]
id: GO:0060364
name: frontal suture morphogenesis
namespace: biological_process
def: "The process by which the frontal suture is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:sl]
is_a: GO:0060363 ! cranial suture morphogenesis

[Term]
id: GO:0060365
name: coronal suture morphogenesis
namespace: biological_process
def: "The process by which the coronal suture is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:sl]
is_a: GO:0060363 ! cranial suture morphogenesis

[Term]
id: GO:0060366
name: lambdoid suture morphogenesis
namespace: biological_process
def: "The process by which the lambdoid suture is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:sl]
is_a: GO:0060363 ! cranial suture morphogenesis

[Term]
id: GO:0060367
name: sagittal suture morphogenesis
namespace: biological_process
def: "The process by which the sagittal suture is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:sl]
is_a: GO:0060363 ! cranial suture morphogenesis

[Term]
id: GO:0060368
name: regulation of Fc receptor mediated stimulatory signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. The Fc receptor mediated stimulatory signaling pathway is a series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:dph, GOC:tb]
synonym: "regulation of Fc receptor mediated stimulatory signalling pathway" EXACT [GOC:mah]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0002431 ! Fc receptor mediated stimulatory signaling pathway

[Term]
id: GO:0060369
name: positive regulation of Fc receptor mediated stimulatory signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. The Fc receptor mediated stimulatory signaling pathway is a series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of Fc receptor mediated stimulatory signalling pathway" EXACT [GOC:mah]
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0060368 ! regulation of Fc receptor mediated stimulatory signaling pathway
relationship: positively_regulates GO:0002431 ! Fc receptor mediated stimulatory signaling pathway

[Term]
id: GO:0060370
name: susceptibility to T cell mediated cytotoxicity
namespace: biological_process
def: "The process of causing a cell to become susceptible to T cell mediated cytotoxicity." [GOC:dph, GOC:tb]
is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity

[Term]
id: GO:0060371
name: regulation of atrial cardiomyocyte membrane depolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte." [GOC:dph, GOC:tb]
synonym: "atrial depolarization" RELATED [GOC:dph, GOC:tb]
synonym: "electrocardiogram PR interval" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of atrial cardiac muscle cell depolarization" EXACT [GOC:dph, GOC:tb]
is_a: GO:0003254 ! regulation of membrane depolarization
is_a: GO:0055117 ! regulation of cardiac muscle contraction

[Term]
id: GO:0060372
name: regulation of atrial cardiomyocyte membrane repolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in an atrial cardiomyocyte." [GOC:dph, GOC:tb]
synonym: "atrial repolarization" RELATED [GOC:dph, GOC:tb]
synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of atrial cardiac muscle cell repolarization" EXACT [GOC:dph, GOC:tb]
is_a: GO:0055117 ! regulation of cardiac muscle contraction
is_a: GO:0060306 ! regulation of membrane repolarization

[Term]
id: GO:0060373
name: regulation of ventricular cardiomyocyte membrane depolarization
namespace: biological_process
def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a ventricular cardiomyocyte." [GOC:dph, GOC:tb]
synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of ventricular cardiac muscle cell membrane depolarization" RELATED []
synonym: "ventricular depolarization" RELATED [GOC:dph, GOC:tb]
is_a: GO:0003254 ! regulation of membrane depolarization
is_a: GO:0055117 ! regulation of cardiac muscle contraction

[Term]
id: GO:0060374
name: mast cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb]
is_a: GO:0002573 ! myeloid leukocyte differentiation

[Term]
id: GO:0060375
name: regulation of mast cell differentiation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mast cell differentiation, the process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb]
is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation
relationship: regulates GO:0060374 ! mast cell differentiation

[Term]
id: GO:0060376
name: positive regulation of mast cell differentiation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mast cell differentiation, the process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb]
is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation
is_a: GO:0060375 ! regulation of mast cell differentiation
relationship: positively_regulates GO:0060374 ! mast cell differentiation

[Term]
id: GO:0060377
name: negative regulation of mast cell differentiation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mast cell differentiation, the process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb]
is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation
is_a: GO:0060375 ! regulation of mast cell differentiation
relationship: negatively_regulates GO:0060374 ! mast cell differentiation

[Term]
id: GO:0060378
name: regulation of brood size
namespace: biological_process
def: "Any process that modulates the extent of brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time." [GOC:dph, GOC:tb]
is_a: GO:0048609 ! reproductive process in a multicellular organism
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0060379
name: cardiac muscle cell myoblast differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:dph, GOC:tb]
synonym: "cardiac myoblast differentiation" RELATED [GOC:dph, GOC:tb]
synonym: "myocardial precursor cell differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0010002 ! cardioblast differentiation

[Term]
id: GO:0060380
name: regulation of single-stranded telomeric DNA binding
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of binding to single-stranded telomeric DNA." [GOC:dph, GOC:tb]
synonym: "regulation of telomeric ssDNA binding" EXACT [GOC:mah]
is_a: GO:0051101 ! regulation of DNA binding

[Term]
id: GO:0060381
name: positive regulation of single-stranded telomeric DNA binding
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of single-stranded telomeric DNA binding." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "positive regulation of telomeric ssDNA binding" EXACT [GOC:mah]
is_a: GO:0043388 ! positive regulation of DNA binding
is_a: GO:0060380 ! regulation of single-stranded telomeric DNA binding

[Term]
id: GO:0060382
name: regulation of DNA strand elongation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process by which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand." [GOC:dph, GOC:tb]
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0022616 ! DNA strand elongation

[Term]
id: GO:0060383
name: positive regulation of DNA strand elongation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process by which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:0060382 ! regulation of DNA strand elongation
relationship: positively_regulates GO:0022616 ! DNA strand elongation

[Term]
id: GO:0060384
name: innervation
namespace: biological_process
def: "The process by which a nerve invades a tissue and makes functional synaptic connection within the tissue." [GOC:dph, GOC:sart]
is_a: GO:0032502 ! developmental process
relationship: part_of GO:0021675 ! nerve development

[Term]
id: GO:0060385
name: axonogenesis involved in innervation
namespace: biological_process
def: "The neurite development process that generates a long process of a neuron, as it invades a target tissue." [GOC:dph, GOC:sart]
is_a: GO:0007409 ! axonogenesis
relationship: part_of GO:0060384 ! innervation

[Term]
id: GO:0060386
name: synaptogenesis involved in innervation
namespace: biological_process
def: "The biosynthesis of a synapse within a target tissue in which a nerve is invading." [GOC:dph, GOC:sart]
is_a: GO:0007416 ! synapse assembly
relationship: part_of GO:0060384 ! innervation

[Term]
id: GO:0060387
name: fertilization envelope
namespace: cellular_component
def: "A structure that lies outside the plasma membrane and surrounds the egg. The fertilization envelope forms from the vitelline membrane after fertilization as a result of cortical granule release." [GOC:dph, ISBN:0878932437]
synonym: "fertilization membrane" RELATED []
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0060388
name: vitelline envelope
namespace: cellular_component
def: "A glycoprotein-based structure that lies outside the plasma membrane and surrounds the egg before fertilization." [GOC:dph, ISBN:0878932437]
synonym: "fertilization membrane" RELATED []
is_a: GO:0030312 ! external encapsulating structure

[Term]
id: GO:0060389
name: pathway-restricted SMAD protein phosphorylation
namespace: biological_process
def: "The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor." [GOC:dph, ISBN:3527303782]
is_a: GO:0006468 ! protein amino acid phosphorylation
relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0060390
name: regulation of SMAD protein nuclear translocation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of SMAD protein nuclear translocation. SMAD protein nuclear translocation is the vectorial transfer of a SMAD proteins from the cytoplasm into the nucleus, through the nuclear pore. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0033158 ! regulation of protein import into nucleus, translocation
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: regulates GO:0007184 ! SMAD protein nuclear translocation

[Term]
id: GO:0060391
name: positive regulation of SMAD protein nuclear translocation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of SMAD protein nuclear translocation. SMAD protein nuclear translocation is the vectorial transfer of a SMAD proteins from the cytoplasm into the nucleus, through the nuclear pore. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0033160 ! positive regulation of protein import into nucleus, translocation
is_a: GO:0060390 ! regulation of SMAD protein nuclear translocation
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: positively_regulates GO:0007184 ! SMAD protein nuclear translocation

[Term]
id: GO:0060392
name: negative regulation of SMAD protein nuclear translocation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of SMAD protein nuclear translocation. SMAD protein nuclear translocation is the vectorial transfer of a SMAD proteins from the cytoplasm into the nucleus, through the nuclear pore. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0033159 ! negative regulation of protein import into nucleus, translocation
is_a: GO:0060390 ! regulation of SMAD protein nuclear translocation
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: negatively_regulates GO:0007184 ! SMAD protein nuclear translocation

[Term]
id: GO:0060393
name: regulation of pathway-restricted SMAD protein phosphorylation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0001932 ! regulation of protein amino acid phosphorylation
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation

[Term]
id: GO:0060394
name: negative regulation of pathway-restricted SMAD protein phosphorylation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of SMAD protein nuclear translocation. SMAD protein nuclear translocation is the vectorial transfer of a SMAD proteins from the cytoplasm into the nucleus, through the nuclear pore. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0001933 ! negative regulation of protein amino acid phosphorylation
is_a: GO:0060393 ! regulation of pathway-restricted SMAD protein phosphorylation
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: negatively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation

[Term]
id: GO:0060395
name: SMAD protein signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0007165 ! signal transduction
relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0060396
name: growth hormone receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph, PMID:11445442]
synonym: "cellular response to growth hormone" RELATED [GOC:dph]
synonym: "GH receptor signaling pathway" RELATED [GOC:dph]
synonym: "growth hormone receptor signalling pathway" EXACT [GOC:dph]
is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway
is_a: GO:0071378 ! cellular response to growth hormone stimulus

[Term]
id: GO:0060397
name: JAK-STAT cascade involved in growth hormone signaling pathway
namespace: biological_process
def: "The process by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes." [GOC:BHF, GOC:dph, PMID:11445442]
synonym: "JAK-STAT cascade involved in growth hormone signalling pathway" EXACT [GOC:dph]
is_a: GO:0007259 ! JAK-STAT cascade
is_a: GO:0023034 ! intracellular signaling pathway
relationship: part_of GO:0060396 ! growth hormone receptor signaling pathway

[Term]
id: GO:0060398
name: regulation of growth hormone receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph]
synonym: "regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0060396 ! growth hormone receptor signaling pathway

[Term]
id: GO:0060399
name: positive regulation of growth hormone receptor signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph]
synonym: "positive regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0060398 ! regulation of growth hormone receptor signaling pathway
relationship: positively_regulates GO:0060396 ! growth hormone receptor signaling pathway

[Term]
id: GO:0060400
name: negative regulation of growth hormone receptor signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:dph]
synonym: "negative regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0060398 ! regulation of growth hormone receptor signaling pathway
relationship: negatively_regulates GO:0060396 ! growth hormone receptor signaling pathway

[Term]
id: GO:0060401
name: cytosolic calcium ion transport
namespace: biological_process
def: "The directed movement of calcium ions (Ca2+) into, out of or within the cytosol." [GOC:dph, GOC:tb]
is_a: GO:0006816 ! calcium ion transport

[Term]
id: GO:0060402
name: calcium ion transport into cytosol
namespace: biological_process
def: "The directed movement of calcium ions (Ca2+) into the cytosol." [GOC:dph, GOC:tb]
is_a: GO:0007204 ! elevation of cytosolic calcium ion concentration
is_a: GO:0060401 ! cytosolic calcium ion transport

[Term]
id: GO:0060403
name: post-mating oviposition
namespace: biological_process
def: "The deposition of eggs, either fertilized or not, upon a surface or into a medium, following mating." [GOC:dph, GOC:tb]
is_a: GO:0018991 ! oviposition
is_a: GO:0045297 ! post-mating behavior

[Term]
id: GO:0060404
name: axonemal microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [GOC:dph, GOC:tb]
is_a: GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0060405
name: regulation of penile erection
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:add, GOC:dph, GOC:tb]
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0043084 ! penile erection

[Term]
id: GO:0060406
name: positive regulation of penile erection
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:dph, GOC:tb]
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0060405 ! regulation of penile erection
relationship: positively_regulates GO:0043084 ! penile erection

[Term]
id: GO:0060407
name: negative regulation of penile erection
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:dph, GOC:tb]
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0060405 ! regulation of penile erection
relationship: negatively_regulates GO:0043084 ! penile erection

[Term]
id: GO:0060408
name: regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
is_a: GO:0033238 ! regulation of cellular amine metabolic process
is_a: GO:0050804 ! regulation of synaptic transmission
is_a: GO:0080090 ! regulation of primary metabolic process
relationship: regulates GO:0008291 ! acetylcholine metabolic process

[Term]
id: GO:0060409
name: positive regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
is_a: GO:0033240 ! positive regulation of cellular amine metabolic process
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
relationship: positively_regulates GO:0008291 ! acetylcholine metabolic process

[Term]
id: GO:0060410
name: negative regulation of acetylcholine metabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb]
is_a: GO:0033239 ! negative regulation of cellular amine metabolic process
is_a: GO:0060408 ! regulation of acetylcholine metabolic process
relationship: negatively_regulates GO:0008291 ! acetylcholine metabolic process

[Term]
id: GO:0060411
name: cardiac septum morphogenesis
namespace: biological_process
alt_id: GO:0003280
def: "The process by which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart." [GOC:dph, GOC:mtg_heart]
synonym: "heart septum morphogenesis" EXACT []
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0003206 ! cardiac chamber morphogenesis
relationship: part_of GO:0003279 ! cardiac septum development

[Term]
id: GO:0060412
name: ventricular septum morphogenesis
namespace: biological_process
def: "The developmental process by which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another." [GOC:dph]
synonym: "interventricular septum morphogenesis" EXACT [GOC:dph]
is_a: GO:0060411 ! cardiac septum morphogenesis
relationship: part_of GO:0003281 ! ventricular septum development

[Term]
id: GO:0060413
name: atrial septum morphogenesis
namespace: biological_process
alt_id: GO:0003287
def: "The developmental process by which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another." [GOC:dph, GOC:mtg_heart]
synonym: "atrial septum morphogenesis" EXACT []
synonym: "interatrial septum morphogenesis" EXACT [GOC:dph]
is_a: GO:0060411 ! cardiac septum morphogenesis
relationship: part_of GO:0003209 ! cardiac atrium morphogenesis
relationship: part_of GO:0003283 ! atrial septum development

[Term]
id: GO:0060414
name: aorta smooth muscle tissue morphogenesis
namespace: biological_process
def: "The process by which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. Morphogenesis pertains to the creation of form. The aorta originates in the left ventricle of the heart and transports oxygenated blood to the rest of the body." [GOC:dph]
is_a: GO:0060415 ! muscle tissue morphogenesis
relationship: part_of GO:0048844 ! artery morphogenesis

[Term]
id: GO:0060415
name: muscle tissue morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function. Morphogenesis pertains to the creation of form." [GOC:dph]
is_a: GO:0048729 ! tissue morphogenesis

[Term]
id: GO:0060416
name: response to growth hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth." [GOC:BHF, GOC:dph]
is_a: GO:0043434 ! response to peptide hormone stimulus

[Term]
id: GO:0060417
name: yolk
namespace: cellular_component
def: "The cytoplasmic part that serves as a nutrient reserve or energy source for the developing embryo." [GOC:dph, GOC:tb, PMID:18046696]
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0060418
name: yolk plasma
namespace: cellular_component
def: "Discrete structures that partition the water-soluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed." [GOC:dph, GOC:tb, PMID:18046696]
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0060417 ! yolk

[Term]
id: GO:0060419
name: heart growth
namespace: biological_process
def: "The increase in size or mass of the heart." [GOC:dph, GOC:tb]
is_a: GO:0035265 ! organ growth
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0060420
name: regulation of heart growth
namespace: biological_process
def: "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:tb]
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0060419 ! heart growth

[Term]
id: GO:0060421
name: positive regulation of heart growth
namespace: biological_process
def: "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0046622 ! positive regulation of organ growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0060420 ! regulation of heart growth
relationship: positively_regulates GO:0060419 ! heart growth

[Term]
id: GO:0060422
name: peptidyl-dipeptidase inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain." [GOC:dph, GOC:tb]
is_a: GO:0030414 ! peptidase inhibitor activity

[Term]
id: GO:0060423
name: foregut regionalization
namespace: biological_process
def: "The pattern specification process by which an axis or axes is subdivided in space along the foregut to define an area or volume in which specific patterns of cell differentiation will take place." [GOC:dph, GOC:mtg_lung]
is_a: GO:0009952 ! anterior/posterior pattern formation

[Term]
id: GO:0060424
name: lung field specification
namespace: biological_process
def: "The process by which a specific region of the foregut is delineated into the area in which the lung will develop." [GOC:dph, GOC:mtg_lung]
synonym: "lung specification" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0010092 ! specification of organ identity
is_a: GO:0060423 ! foregut regionalization
relationship: part_of GO:0060431 ! primary lung bud formation

[Term]
id: GO:0060425
name: lung morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the lung are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060426
name: lung vasculature development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary vasculature development" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0001944 ! vasculature development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060427
name: lung connective tissue development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary connective tissue development" EXACT []
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060428
name: lung epithelium development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary epithelium development" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060429
name: epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0060430
name: lung saccule development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lung saccule from an initial condition to its mature state. The lung saccule is the primitive gas exchange portion of the lung composed of type I and type II cells." [GOC:dph, GOC:mtg_lung]
synonym: "lung saccular development" BROAD [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060431
name: primary lung bud formation
namespace: biological_process
def: "The morphogenetic process whereby the foregut region specified to become the lung forms the initial left and right buds." [GOC:dph, GOC:mtg_lung]
synonym: "lung formation" EXACT [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048645 ! organ formation
is_a: GO:0060441 ! branching involved in lung morphogenesis
is_a: GO:0060572 ! morphogenesis of an epithelial bud

[Term]
id: GO:0060432
name: lung pattern specification process
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within the lung, to which cells respond and eventually are instructed to differentiate." [GOC:dph]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060433
name: bronchus development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph]
is_a: GO:0048513 ! organ development
relationship: part_of GO:0060541 ! respiratory system development

[Term]
id: GO:0060434
name: bronchus morphogenesis
namespace: biological_process
def: "The process by which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0060433 ! bronchus development

[Term]
id: GO:0060435
name: bronchiole development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi." [GOC:dph, GOC:mtg_lung]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060436
name: bronchiole morphogenesis
namespace: biological_process
def: "The process by which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060435 ! bronchiole development

[Term]
id: GO:0060437
name: lung growth
namespace: biological_process
def: "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:dph]
is_a: GO:0035265 ! organ growth
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060438
name: trachea development
namespace: biological_process
def: "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
is_a: GO:0048513 ! organ development
relationship: part_of GO:0060541 ! respiratory system development

[Term]
id: GO:0060439
name: trachea morphogenesis
namespace: biological_process
def: "The process by which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0060438 ! trachea development

[Term]
id: GO:0060440
name: trachea formation
namespace: biological_process
def: "The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph]
is_a: GO:0048645 ! organ formation
relationship: part_of GO:0060439 ! trachea morphogenesis

[Term]
id: GO:0060441
name: branching involved in lung morphogenesis
namespace: biological_process
def: "The process whereby a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:mtg_lung]
synonym: "lung branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of a tube
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0060425 ! lung morphogenesis

[Term]
id: GO:0060442
name: branching involved in prostate gland morphogenesis
namespace: biological_process
def: "The process by which the branching structure of the prostate gland is generated and organized. Morphogenesis pertains to the creation of form. A branch is a division or offshoot from a main stem." [GOC:dph]
synonym: "prostate branching" RELATED [GOC:dph]
synonym: "prostate gland branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0001763 ! morphogenesis of a branching structure
is_a: GO:0060740 ! prostate gland epithelium morphogenesis

[Term]
id: GO:0060443
name: mammary gland morphogenesis
namespace: biological_process
def: "The process by which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph]
is_a: GO:0022612 ! gland morphogenesis
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0060444
name: branching involved in mammary gland duct morphogenesis
namespace: biological_process
def: "The process by which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph]
synonym: "mammary gland branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of a tube
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis

[Term]
id: GO:0060445
name: branching involved in salivary gland morphogenesis
namespace: biological_process
def: "The process by which the branching structure of the salivary gland is generated and organized." [GOC:dph]
is_a: GO:0001763 ! morphogenesis of a branching structure
relationship: part_of GO:0007435 ! salivary gland morphogenesis

[Term]
id: GO:0060446
name: branching involved in open tracheal system development
namespace: biological_process
def: "The process by which the anatomical structures of branches in the open tracheal system are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph]
is_a: GO:0048754 ! branching morphogenesis of a tube
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0007424 ! open tracheal system development

[Term]
id: GO:0060447
name: bud outgrowth involved in lung branching
namespace: biological_process
def: "The process whereby a region of the lung epithelium initiates an outgrowth." [GOC:dph, GOC:mtg_lung]
synonym: "bud formation involved in lung branching" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0060602 ! branch elongation of an epithelium
relationship: part_of GO:0060441 ! branching involved in lung morphogenesis

[Term]
id: GO:0060448
name: dichotomous subdivision of terminal units involved in lung branching
namespace: biological_process
def: "The process whereby a lung bud bifurcates." [GOC:dph, GOC:mtg_lung]
synonym: "bud bifurcation involved in lung branching" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
relationship: part_of GO:0060441 ! branching involved in lung morphogenesis

[Term]
id: GO:0060449
name: bud elongation involved in lung branching
namespace: biological_process
def: "The process whereby a bud in the lung grows out from the point where it is formed." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060602 ! branch elongation of an epithelium
relationship: part_of GO:0060441 ! branching involved in lung morphogenesis

[Term]
id: GO:0060450
name: positive regulation of hindgut contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb]
is_a: GO:0043134 ! regulation of hindgut contraction
is_a: GO:0045987 ! positive regulation of smooth muscle contraction
is_a: GO:0060456 ! positive regulation of digestive system process
relationship: positively_regulates GO:0043133 ! hindgut contraction

[Term]
id: GO:0060451
name: negative regulation of hindgut contraction
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb]
is_a: GO:0043134 ! regulation of hindgut contraction
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
is_a: GO:0060457 ! negative regulation of digestive system process
relationship: negatively_regulates GO:0043133 ! hindgut contraction

[Term]
id: GO:0060452
name: positive regulation of cardiac muscle contraction
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cardiac muscle contraction." [GOC:dph, GOC:tb]
is_a: GO:0045989 ! positive regulation of striated muscle contraction
is_a: GO:0055117 ! regulation of cardiac muscle contraction
relationship: positively_regulates GO:0060048 ! cardiac muscle contraction

[Term]
id: GO:0060453
name: regulation of gastric acid secretion
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051046 ! regulation of secretion
relationship: regulates GO:0001696 ! gastric acid secretion

[Term]
id: GO:0060454
name: positive regulation of gastric acid secretion
namespace: biological_process
def: "Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0060453 ! regulation of gastric acid secretion
is_a: GO:0060456 ! positive regulation of digestive system process
relationship: positively_regulates GO:0001696 ! gastric acid secretion

[Term]
id: GO:0060455
name: negative regulation of gastric acid secretion
namespace: biological_process
def: "Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0060453 ! regulation of gastric acid secretion
is_a: GO:0060457 ! negative regulation of digestive system process
relationship: negatively_regulates GO:0001696 ! gastric acid secretion

[Term]
id: GO:0060456
name: positive regulation of digestive system process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
relationship: positively_regulates GO:0022600 ! digestive system process

[Term]
id: GO:0060457
name: negative regulation of digestive system process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
relationship: negatively_regulates GO:0022600 ! digestive system process

[Term]
id: GO:0060458
name: right lung development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung]
synonym: "right pulmonary development" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0030324 ! lung development

[Term]
id: GO:0060459
name: left lung development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung]
synonym: "left pulmonary development" EXACT [GOC:dph]
is_a: GO:0030324 ! lung development

[Term]
id: GO:0060460
name: left lung morphogenesis
namespace: biological_process
def: "The process by which anatomical structures of the left lung are generated and organized." [GOC:dph]
is_a: GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060459 ! left lung development

[Term]
id: GO:0060461
name: right lung morphogenesis
namespace: biological_process
def: "The process by which anatomical structures of the right lung are generated and organized." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060458 ! right lung development

[Term]
id: GO:0060462
name: lung lobe development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060463
name: lung lobe morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a lung lobe are generated and organized. Morphogenesis pertains to the creation of form. A lung lobe is a projection that extends from the lung." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060462 ! lung lobe development

[Term]
id: GO:0060464
name: lung lobe formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung." [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060463 ! lung lobe morphogenesis

[Term]
id: GO:0060465
name: pharynx development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth." [GOC:dph, GOC:rk]
synonym: "pharyngeal development" RELATED []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0055123 ! digestive system development

[Term]
id: GO:0060466
name: activation of meiosis involved in egg activation
namespace: biological_process
def: "Any process that starts the inactive process of meiosis in an egg after the egg has been fertilized or physiologically activated. Eggs generally arrest in meiosis and complete the process after activation." [GOC:dph]
synonym: "reactivation of meiosis after fertilization" NARROW [GOC:dph]
synonym: "resumption of meiosis involved in egg activation" EXACT [GOC:dph]
is_a: GO:0045836 ! positive regulation of meiosis
relationship: part_of GO:0007343 ! egg activation

[Term]
id: GO:0060467
name: negative regulation of fertilization
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:dph]
is_a: GO:0048519 ! negative regulation of biological process
relationship: negatively_regulates GO:0009566 ! fertilization

[Term]
id: GO:0060468
name: prevention of polyspermy
namespace: biological_process
def: "The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg." [GOC:dph]
synonym: "negative regulation of fertilization involved in egg activation" EXACT [GOC:dph]
synonym: "polyspermy block" EXACT [GOC:dph]
is_a: GO:0060467 ! negative regulation of fertilization
relationship: part_of GO:0007343 ! egg activation

[Term]
id: GO:0060469
name: positive regulation of transcription involved in egg activation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of transcription as a part of the process of egg activation." [GOC:dph]
synonym: "activation of the egg genome" RELATED [GOC:dph]
synonym: "activation of the maternal genome" RELATED [GOC:dph]
is_a: GO:0045941 ! positive regulation of transcription
relationship: part_of GO:0007343 ! egg activation

[Term]
id: GO:0060470
name: elevation of cytosolic calcium ion concentration involved in egg activation
namespace: biological_process
def: "The process that increases the concentration of calcium ions in the cytosol after fertilization or the physiological activation of an egg." [GOC:dph]
is_a: GO:0007204 ! elevation of cytosolic calcium ion concentration
relationship: part_of GO:0007343 ! egg activation

[Term]
id: GO:0060471
name: cortical granule exocytosis
namespace: biological_process
def: "The process of secretion by a cell that results in the release of intracellular molecules contained within a cortical granule by fusion of the vesicle with the plasma membrane of a cell. A cortical granule is a specialized secretory vesicle that is released during egg activation that changes the surface of the egg to prevent polyspermy." [GOC:dph]
synonym: "cortical granule release" RELATED [GOC:dph]
is_a: GO:0017156 ! calcium ion-dependent exocytosis
relationship: part_of GO:0060468 ! prevention of polyspermy

[Term]
id: GO:0060472
name: positive regulation of cortical granule exocytosis by elevation of cytosolic calcium ion concentration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cortical granule exocytosis by directing movement of calcium ions (Ca2+) into the cytosol." [GOC:dph]
is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis
is_a: GO:0050865 ! regulation of cell activation
is_a: GO:0060470 ! elevation of cytosolic calcium ion concentration involved in egg activation
relationship: positively_regulates GO:0060471 ! cortical granule exocytosis

[Term]
id: GO:0060473
name: cortical granule
namespace: cellular_component
def: "A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy." [GOC:dph]
synonym: "cortical vesicle" RELATED [GOC:dph]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0060474
name: positive regulation of sperm motility involved in capacitation
namespace: biological_process
def: "The process by which the controlled movement of a sperm cell is initiated as part of the process required for sperm to reach fertilization competence." [GOC:dph]
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0051272 ! positive regulation of cellular component movement
relationship: part_of GO:0048240 ! sperm capacitation
relationship: positively_regulates GO:0030317 ! sperm motility

[Term]
id: GO:0060475
name: positive regulation of actin filament polymerization involved in acrosome reaction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of actin polymerization as part of the acrosome reaction." [GOC:dph]
synonym: "positive regulation of actin polymerization involved in acrosome reaction" RELATED [GOC:dph]
is_a: GO:0030838 ! positive regulation of actin filament polymerization
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0060476
name: protein localization involved in acrosome reaction
namespace: biological_process
def: "The actin-based process by which a protein is transported to, or maintained in, a specific location in the sperm as part of the acrosome reaction." [GOC:dph]
is_a: GO:0008105 ! asymmetric protein localization
is_a: GO:0030029 ! actin filament-based process
is_a: GO:0034613 ! cellular protein localization
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0060477
name: peptidyl-serine phosphorylation involved in acrosome reaction
namespace: biological_process
def: "The posttranslational phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine that is part of the acrosome reaction." [GOC:dph]
is_a: GO:0018105 ! peptidyl-serine phosphorylation
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0060478
name: acrosomal vesicle exocytosis
namespace: biological_process
def: "The release of intracellular molecules contained within the acrosomal granule by fusion of the vesicle with the plasma membrane of the oocyte, requiring calcium ions." [GOC:dph]
synonym: "acrosomal granule exocytosis" RELATED [GOC:dph]
synonym: "acrosome exocytosis" EXACT [GOC:dph]
is_a: GO:0017156 ! calcium ion-dependent exocytosis
relationship: part_of GO:0007340 ! acrosome reaction

[Term]
id: GO:0060479
name: lung cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary cell differentiation" EXACT [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060480
name: lung goblet cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a lung goblet cell. A goblet cell is a cell of the epithelial lining that produces and secretes mucins." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary goblet cell differentiation" EXACT []
is_a: GO:0060487 ! lung epithelial cell differentiation
relationship: part_of GO:0060481 ! lobar bronchus epithelium development

[Term]
id: GO:0060481
name: lobar bronchus epithelium development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lobar bronchus epithelium from an initial condition to its mature state. This process begins with the formation of the lobar bronchus epithelium and ends with the mature structure. The lobar bronchus epithelium is the tissue made up of epithelial cells that lines the inside of the lobar bronchus." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060428 ! lung epithelium development
relationship: part_of GO:0060482 ! lobar bronchus development

[Term]
id: GO:0060482
name: lobar bronchus development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lobar bronchus from an initial condition to its mature state. This process begins with the formation of the lobar bronchus and ends with the mature structure. The lobar bronchus is the major airway within the respiratory tree that starts by division of the principal bronchi on both sides and ends at the point of its own subdivision into tertiary or segmental bronchi." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060433 ! bronchus development

[Term]
id: GO:0060483
name: lobar bronchus mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lobar bronchus mesenchyme from an initial condition to its mature state. This process begins with the formation of the lobar bronchus mesenchyme and ends with the mature structure. The lobar bronchus mesenchyme is the mass of tissue composed of mesenchymal cells in the lobar bronchus." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060484 ! lung-associated mesenchyme development
relationship: part_of GO:0060482 ! lobar bronchus development

[Term]
id: GO:0060484
name: lung-associated mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung." [GOC:dph, GOC:mtg_lung]
synonym: "lung mesenchyme development" EXACT [GOC:dph]
synonym: "pulmonary mesenchyme development" EXACT [GOC:dph]
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060485
name: mesenchyme development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:dph]
synonym: "mesenchymal development" EXACT [GOC:dph]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0060486
name: Clara cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a Clara cell. A Clara cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060487 ! lung epithelial cell differentiation

[Term]
id: GO:0060487
name: lung epithelial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung." [GOC:dph]
synonym: "pulmonary epithelial cell differentiation" RELATED [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0060479 ! lung cell differentiation
relationship: part_of GO:0060428 ! lung epithelium development

[Term]
id: GO:0060488
name: orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
namespace: biological_process
def: "The process whereby a lung bud bifurcates perpendicular to the plane of the parental branch." [GOC:dph, GOC:mtg_lung]
synonym: "perpendicular dichotomous subdivision of terminal units involved in lung branching morphogenesis" EXACT [GOC:dph]
is_a: GO:0060448 ! dichotomous subdivision of terminal units involved in lung branching

[Term]
id: GO:0060489
name: planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
namespace: biological_process
def: "The process whereby a lung bud bifurcates parallel to the plane of its parent." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060448 ! dichotomous subdivision of terminal units involved in lung branching

[Term]
id: GO:0060490
name: lateral sprouting involved in lung morphogenesis
namespace: biological_process
def: "The process whereby a branch forms along the side of the lung epithelial tube." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060601 ! lateral sprouting from an epithelium
relationship: part_of GO:0060441 ! branching involved in lung morphogenesis

[Term]
id: GO:0060491
name: regulation of cell projection assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cell projection assembly." [GOC:dph, GOC:tb]
synonym: "regulation of cell projection formation" RELATED [GOC:dph, GOC:tb]
is_a: GO:0031344 ! regulation of cell projection organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
relationship: regulates GO:0030031 ! cell projection assembly

[Term]
id: GO:0060492
name: lung induction
namespace: biological_process
def: "The close range interaction of two or more cells or tissues that causes the cells of the foregut to change their fates and specify the development of the lung." [GOC:dph]
is_a: GO:0001759 ! induction of an organ
relationship: positively_regulates GO:0060424 ! lung field specification

[Term]
id: GO:0060493
name: mesenchymal-endodermal cell signaling involved in lung induction
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell and contributes to the formation of the lung bud." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060494 ! inductive mesenchymal-endodermal cell signaling
is_a: GO:0060496 ! mesenchymal-endodermal cell signaling involved in lung development
relationship: part_of GO:0060492 ! lung induction

[Term]
id: GO:0060494
name: inductive mesenchymal-endodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell changing the fate of the endodermal cell." [GOC:dph, GOC:mtg_lung]
is_a: GO:0031129 ! inductive cell-cell signaling

[Term]
id: GO:0060495
name: cell-cell signaling involved in lung development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure." [GOC:dph, GOC:mtg_lung]
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060496
name: mesenchymal-endodermal cell signaling involved in lung development
namespace: biological_process
def: "Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell and contributes to the development of the lung." [GOC:dph, GOC:mtg_lung]
is_a: GO:0060495 ! cell-cell signaling involved in lung development
is_a: GO:0060497 ! mesenchymal-endodermal cell signaling

[Term]
id: GO:0060497
name: mesenchymal-endodermal cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell." [GOC:dph]
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling

[Term]
id: GO:0060498
name: retinoic acid receptor signaling pathway involved in lung bud formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands contributing to the formation of the primary lung bud." [GOC:dph, GOC:mtg_lung]
is_a: GO:0048384 ! retinoic acid receptor signaling pathway
relationship: part_of GO:0060431 ! primary lung bud formation

[Term]
id: GO:0060499
name: fibroblast growth factor receptor signaling pathway involved in lung induction
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands resulting in the formation of the lung bud along the lateral-esophageal sulcus." [GOC:dph, GOC:mtg_lung]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
is_a: GO:0031131 ! reception of an inductive signal
relationship: part_of GO:0060493 ! mesenchymal-endodermal cell signaling involved in lung induction

[Term]
id: GO:0060500
name: regulation of transcription from RNA polymerase II promoter involved in lung bud formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the initial primordium of the lung is formed." [GOC:dph, GOC:mtg_lung]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0060431 ! primary lung bud formation

[Term]
id: GO:0060501
name: positive regulation of epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape." [GOC:dph]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: positively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis

[Term]
id: GO:0060502
name: epithelial cell proliferation involved in lung morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung." [GOC:dph]
is_a: GO:0050673 ! epithelial cell proliferation
relationship: part_of GO:0060425 ! lung morphogenesis
relationship: part_of GO:0060428 ! lung epithelium development

[Term]
id: GO:0060503
name: bud dilation involved in lung branching
namespace: biological_process
def: "The process whereby a bud in the lung increases radially." [GOC:dph]
synonym: "bud expansion" EXACT [GOC:dph]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060441 ! branching involved in lung morphogenesis

[Term]
id: GO:0060504
name: positive regulation of epithelial cell proliferation involved in lung bud dilation
namespace: biological_process
def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung bud increasing in size radially." [GOC:dph]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0060501 ! positive regulation of epithelial cell proliferation involved in lung morphogenesis
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:0061047 ! positive regulation of branching involved in lung morphogenesis
relationship: positively_regulates GO:0060505 ! epithelial cell proliferation involved in lung bud dilation

[Term]
id: GO:0060505
name: epithelial cell proliferation involved in lung bud dilation
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells that contribute to the radial growth of a lung bud." [GOC:dph]
is_a: GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis
relationship: part_of GO:0060503 ! bud dilation involved in lung branching

[Term]
id: GO:0060506
name: smoothened signaling pathway involved in lung development
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein. This process contributes to lung development." [GOC:dph, GOC:mtg_lung]
is_a: GO:0007224 ! smoothened signaling pathway
relationship: part_of GO:0060495 ! cell-cell signaling involved in lung development

[Term]
id: GO:0060507
name: epidermal growth factor receptor signaling pathway involved in lung development
namespace: biological_process
def: "The series of molecular signals generated as a consequence of an epidermal growth factor-type receptor binding to one of its physiological ligands. This process contributes to lung development." [GOC:dph, GOC:mtg_lung]
is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway
relationship: part_of GO:0060495 ! cell-cell signaling involved in lung development

[Term]
id: GO:0060508
name: lung basal cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature basal cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. A basal cell is an epithelial stem cell." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary basal cell differentiation" EXACT [GOC:dph, GOC:mtg_lung]
is_a: GO:0060479 ! lung cell differentiation
relationship: part_of GO:0060481 ! lobar bronchus epithelium development

[Term]
id: GO:0060509
name: Type I pneumocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a Type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles." [GOC:dph, GOC:mtg_lung, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "membranous pneumocyte differentiation" EXACT [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "small alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "squamous alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0060487 ! lung epithelial cell differentiation

[Term]
id: GO:0060510
name: Type II pneumocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a Type II pneumocyte. A Type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies." [GOC:dph, GOC:mtg_lung, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "granular pneumocyte differentiation" RELATED [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "great alveolar cell differentiation" EXACT [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
synonym: "large alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"]
is_a: GO:0060487 ! lung epithelial cell differentiation

[Term]
id: GO:0060511
name: creation of an inductive signal by a mesenchymal cell involved in lung induction
namespace: biological_process
def: "The process by which splanchnic mesenchymal cells send a signal over a short range to endodermal cells inducing them to form the primary lung bud." [GOC:dph, GOC:mtg_lung]
is_a: GO:0031130 ! creation of an inductive signal
relationship: part_of GO:0060493 ! mesenchymal-endodermal cell signaling involved in lung induction

[Term]
id: GO:0060512
name: prostate gland morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a prostate gland are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, PMID:18977204]
is_a: GO:0009887 ! organ morphogenesis
is_a: GO:0022612 ! gland morphogenesis
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060513
name: prostatic bud formation
namespace: biological_process
def: "The morphogenetic process whereby a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph, PMID:18977204]
synonym: "primary prostate bud formation" EXACT [GOC:dph]
synonym: "prostate ductal budding" EXACT [GOC:dph, PMID:11401393]
synonym: "prostate gland formation" EXACT [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048645 ! organ formation
is_a: GO:0060572 ! morphogenesis of an epithelial bud
is_a: GO:0060601 ! lateral sprouting from an epithelium
is_a: GO:0060740 ! prostate gland epithelium morphogenesis

[Term]
id: GO:0060514
name: prostate induction
namespace: biological_process
def: "The close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland." [GOC:dph, PMID:18977204]
is_a: GO:0001759 ! induction of an organ
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0060685 ! regulation of prostatic bud formation
relationship: positively_regulates GO:0060515 ! prostate field specification

[Term]
id: GO:0060515
name: prostate field specification
namespace: biological_process
def: "The process by which a specific region of the urogenital sinus epithelium is delineated into the area in which the prostate gland will develop." [GOC:dph, PMID:18977204]
is_a: GO:0010092 ! specification of organ identity
relationship: part_of GO:0060513 ! prostatic bud formation

[Term]
id: GO:0060516
name: primary prostatic bud elongation
namespace: biological_process
def: "The increase in size of the prostatic bud as it forms." [GOC:dph, PMID:18977204]
synonym: "prostate bud elongation" BROAD [GOC:dph]
synonym: "prostate bud elongation involved in prostate morphogenesis" EXACT [GOC:dph]
is_a: GO:0060602 ! branch elongation of an epithelium
is_a: GO:0060737 ! prostate gland morphogenetic growth
is_a: GO:0060740 ! prostate gland epithelium morphogenesis

[Term]
id: GO:0060517
name: epithelial cell proliferation involved in prostatic bud elongation
namespace: biological_process
def: "The multiplication of epithelial cells, contributing to the expansion of the primary prostatic bud." [GOC:dph, PMID:18977204]
is_a: GO:0060767 ! epithelial cell proliferation involved in prostate gland development
relationship: part_of GO:0060516 ! primary prostatic bud elongation

[Term]
id: GO:0060518
name: cell migration involved in prostatic bud elongation
namespace: biological_process
def: "The orderly movement of epithelial cells from one site to another contributing to the elongation of the primary prostatic bud." [GOC:dph, PMID:18977204]
is_a: GO:0010631 ! epithelial cell migration
relationship: part_of GO:0060516 ! primary prostatic bud elongation

[Term]
id: GO:0060519
name: cell adhesion involved in prostatic bud elongation
namespace: biological_process
def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the elongation of the primary prostatic bud." [GOC:dph, PMID:18977204]
is_a: GO:0007155 ! cell adhesion
relationship: part_of GO:0060516 ! primary prostatic bud elongation

[Term]
id: GO:0060520
name: activation of prostate induction by androgen receptor signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of an androgen binding to its receptor in The process by which any series of molecular signals generated as a consequence of an androgen binding to its receptor in the urogenital sinus mesenchyme initiates prostate induction. Prostate induction is the close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland." [GOC:dph, GOC:tb, PMID:18977204]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0030521 ! androgen receptor signaling pathway
is_a: GO:0042659 ! regulation of cell fate specification
relationship: positively_regulates GO:0060514 ! prostate induction

[Term]
id: GO:0060521
name: mesenchymal-epithelial cell signaling involved in prostate induction
namespace: biological_process
def: "Signaling at short range from urogenital sinus mesenchymal cells to cells of the urogenital epithelium resulting in the epithelial cells adopting a prostatic fate." [GOC:dph, PMID:18977204]
is_a: GO:0060522 ! inductive mesenchymal to epithelial cell signaling
is_a: GO:0060739 ! mesenchymal-epithelial cell signaling involved in prostate gland development
relationship: part_of GO:0060514 ! prostate induction

[Term]
id: GO:0060522
name: inductive mesenchymal to epithelial cell signaling
namespace: biological_process
def: "Signaling at short range from mesenchymal cells to cells of an epithelium that results in a developmental change in the epithelial cells." [GOC:dph]
is_a: GO:0031129 ! inductive cell-cell signaling

[Term]
id: GO:0060523
name: prostate epithelial cord elongation
namespace: biological_process
def: "The developmental growth process by which solid chords of prostate epithelium increase in length." [GOC:dph, PMID:18977204]
is_a: GO:0060602 ! branch elongation of an epithelium
is_a: GO:0060737 ! prostate gland morphogenetic growth
is_a: GO:0060740 ! prostate gland epithelium morphogenesis
relationship: part_of GO:0060442 ! branching involved in prostate gland morphogenesis

[Term]
id: GO:0060524
name: dichotomous subdivision of prostate epithelial cord terminal unit
namespace: biological_process
def: "The process whereby a prostate epithelial cord bifurcates at its end." [GOC:dph, PMID:18977204]
synonym: "prostate epithelial cord bifurcation" EXACT [GOC:dph]
is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
relationship: part_of GO:0060442 ! branching involved in prostate gland morphogenesis

[Term]
id: GO:0060525
name: prostate glandular acinus development
namespace: biological_process
def: "The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland." [GOC:dph, PMID:18977204]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060526
name: prostate glandular acinus morphogenesis
namespace: biological_process
def: "The process by which the prostate glandular acini are generated and organized. The glandular acini are the saclike structures of the gland." [GOC:dph]
is_a: GO:0060740 ! prostate gland epithelium morphogenesis
relationship: part_of GO:0060525 ! prostate glandular acinus development

[Term]
id: GO:0060527
name: prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
namespace: biological_process
def: "The branching morphogenesis process by which the prostate epithelial cords branch freely to create the structure of the prostate acini." [GOC:dph, PMID:18977204]
is_a: GO:0060442 ! branching involved in prostate gland morphogenesis
relationship: part_of GO:0060526 ! prostate glandular acinus morphogenesis

[Term]
id: GO:0060528
name: secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
namespace: biological_process
def: "The process whereby a relatively unspecialized epithelial cell acquires specialized features of a secretory columnal luminar epithelial cell of the prostate." [GOC:dph, PMID:18977204]
is_a: GO:0002067 ! glandular epithelial cell differentiation
is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development
relationship: part_of GO:0060525 ! prostate glandular acinus development

[Term]
id: GO:0060529
name: squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
namespace: biological_process
def: "The process whereby a relatively unspecialized epithelial cell acquires specialized features of a squamous basal epithelial stem cell of the prostate." [GOC:dph, PMID:18977204]
is_a: GO:0002067 ! glandular epithelial cell differentiation
is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development
relationship: part_of GO:0060525 ! prostate glandular acinus development

[Term]
id: GO:0060530
name: smooth muscle cell differentiation involved in prostate glandular acinus development
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the prostate glandular acinus." [GOC:dph, PMID:18977204]
is_a: GO:0051145 ! smooth muscle cell differentiation
relationship: part_of GO:0060525 ! prostate glandular acinus development

[Term]
id: GO:0060531
name: neuroendocrine cell differentiation involved in prostate gland acinus development
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquires specialized structural and functions of a neuroendocrine cell of the prostate gland acinus." [GOC:dph, PMID:18977204]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0060525 ! prostate glandular acinus development

[Term]
id: GO:0060532
name: bronchus cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph, GOC:mtg_lung]
synonym: "pulmonary cartilage development" EXACT []
is_a: GO:0051216 ! cartilage development
relationship: part_of GO:0060433 ! bronchus development

[Term]
id: GO:0060533
name: bronchus cartilage morphogenesis
namespace: biological_process
def: "The process by which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs." [GOC:dph]
is_a: GO:0060536 ! cartilage morphogenesis
relationship: part_of GO:0060434 ! bronchus morphogenesis
relationship: part_of GO:0060532 ! bronchus cartilage development

[Term]
id: GO:0060534
name: trachea cartilage development
namespace: biological_process
def: "The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:0051216 ! cartilage development
relationship: part_of GO:0060438 ! trachea development

[Term]
id: GO:0060535
name: trachea cartilage morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of cartilage in the trachea are generated and organized." [GOC:dph]
is_a: GO:0060536 ! cartilage morphogenesis
relationship: part_of GO:0060439 ! trachea morphogenesis
relationship: part_of GO:0060534 ! trachea cartilage development

[Term]
id: GO:0060536
name: cartilage morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of cartilage are generated and organized." [GOC:dph]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0051216 ! cartilage development

[Term]
id: GO:0060537
name: muscle tissue development
namespace: biological_process
def: "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0007517 ! muscle organ development

[Term]
id: GO:0060538
name: skeletal muscle organ development
namespace: biological_process
def: "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue." [GOC:dph]
is_a: GO:0007517 ! muscle organ development

[Term]
id: GO:0060539
name: diaphragm development
namespace: biological_process
def: "The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs." [GOC:dph]
is_a: GO:0060538 ! skeletal muscle organ development
relationship: part_of GO:0060541 ! respiratory system development

[Term]
id: GO:0060540
name: diaphragm morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the diaphragm are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph]
is_a: GO:0048644 ! muscle organ morphogenesis
relationship: part_of GO:0060539 ! diaphragm development

[Term]
id: GO:0060541
name: respiratory system development
namespace: biological_process
def: "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph]
is_a: GO:0048731 ! system development

[Term]
id: GO:0060542
name: regulation of strand invasion
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:dph, GOC:tb]
is_a: GO:0000018 ! regulation of DNA recombination
relationship: regulates GO:0042148 ! strand invasion

[Term]
id: GO:0060543
name: negative regulation of strand invasion
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:dph, GOC:elh, GOC:tb]
synonym: "negative regulation of D-loop biosynthesis" RELATED [GOC:elh]
synonym: "negative regulation of D-loop formation" RELATED [GOC:elh]
synonym: "negative regulation of Rad51-mediated strand invasion" EXACT [GOC:elh]
is_a: GO:0045910 ! negative regulation of DNA recombination
is_a: GO:0060542 ! regulation of strand invasion
relationship: negatively_regulates GO:0042148 ! strand invasion

[Term]
id: GO:0060544
name: regulation of necroptosis
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of necroptosis. Necroptosis is a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010939 ! regulation of necrotic cell death
relationship: regulates GO:0070266 ! necroptosis

[Term]
id: GO:0060545
name: positive regulation of necroptosis
namespace: biological_process
def: "Any process that increases the rate frequency or extent of necroptosis. Necroptosis is a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010940 ! positive regulation of necrotic cell death
is_a: GO:0060544 ! regulation of necroptosis
relationship: positively_regulates GO:0070266 ! necroptosis

[Term]
id: GO:0060546
name: negative regulation of necroptosis
namespace: biological_process
def: "Any process that decreases the rate frequency or extent of necroptosis. Necroptosis is a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0060544 ! regulation of necroptosis
is_a: GO:0060547 ! negative regulation of necrotic cell death
relationship: negatively_regulates GO:0070266 ! necroptosis

[Term]
id: GO:0060547
name: negative regulation of necrotic cell death
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010939 ! regulation of necrotic cell death
is_a: GO:0060548 ! negative regulation of cell death
relationship: negatively_regulates GO:0070265 ! necrotic cell death

[Term]
id: GO:0060548
name: negative regulation of cell death
namespace: biological_process
def: "Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010941 ! regulation of cell death
is_a: GO:0048523 ! negative regulation of cellular process
relationship: negatively_regulates GO:0008219 ! cell death

[Term]
id: GO:0060549
name: regulation of fructose 1,6-bisphosphate 1-phosphatase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of fructose 1,6-bisphosphate 1-phosphatase activity. Fructose 1,6-bisphosphate 1-phosphatase activity is the catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032113 ! regulation of carbohydrate phosphatase activity

[Term]
id: GO:0060550
name: positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of fructose 1,6-bisphosphate 1-phosphatase activity. Fructose 1,6-bisphosphate 1-phosphatase activity is the catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010922 ! positive regulation of phosphatase activity
is_a: GO:0060549 ! regulation of fructose 1,6-bisphosphate 1-phosphatase activity

[Term]
id: GO:0060551
name: regulation of fructose 1,6-bisphosphate metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of fructose 1,6-bisphosphate metabolism. Fructose 1,6-bisphosphate metabolism is the chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
relationship: regulates GO:0030388 ! fructose 1,6-bisphosphate metabolic process

[Term]
id: GO:0060552
name: positive regulation of fructose 1,6-bisphosphate metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of fructose 1,6-bisphosphate metabolism. Fructose 1,6-bisphosphate metabolism is the chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0060551 ! regulation of fructose 1,6-bisphosphate metabolic process
relationship: positively_regulates GO:0030388 ! fructose 1,6-bisphosphate metabolic process

[Term]
id: GO:0060553
name: induction of necroptosis
namespace: biological_process
def: "Any process that starts the inactive process of necroptosis. Necroptosis is a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "activation of necroptosis" EXACT [GOC:dph, GOC:tb]
is_a: GO:0060545 ! positive regulation of necroptosis

[Term]
id: GO:0060554
name: induction of necroptosis of activated-T cells
namespace: biological_process
def: "Any process that starts the inactive process of necroptosis in an activated T cell. Necroptosis is a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0060553 ! induction of necroptosis

[Term]
id: GO:0060555
name: induction of necroptosis by extracellular signals
namespace: biological_process
def: "Any process that starts the inactive process of necroptosis as a result of a signal outside the cell. Necroptosis is a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0060553 ! induction of necroptosis

[Term]
id: GO:0060556
name: regulation of vitamin D biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [ChEBI:27300, GOC:BHF, GOC:mah, ISBN:0471331309]
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
relationship: regulates GO:0042368 ! vitamin D biosynthetic process

[Term]
id: GO:0060557
name: positive regulation of vitamin D biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [ChEBI:27300, GOC:BHF, GOC:mah, ISBN:0471331309]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0046136 ! positive regulation of vitamin metabolic process
is_a: GO:0060556 ! regulation of vitamin D biosynthetic process
relationship: positively_regulates GO:0042368 ! vitamin D biosynthetic process

[Term]
id: GO:0060558
name: regulation of calcidiol 1-monooxygenase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032768 ! regulation of monooxygenase activity

[Term]
id: GO:0060559
name: positive regulation of calcidiol 1-monooxygenase activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032770 ! positive regulation of monooxygenase activity
is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity

[Term]
id: GO:0060560
name: developmental growth involved in morphogenesis
namespace: biological_process
def: "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph]
synonym: "differential growth" EXACT [GOC:dph]
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0060561
name: apoptosis involved in morphogenesis
namespace: biological_process
def: "The process of apoptosis that contributes to the shaping of an anatomical structure." [GOC:dph]
synonym: "morphogenetic apoptosis" RELATED [GOC:dph]
is_a: GO:0006915 ! apoptosis
is_a: GO:0010623 ! developmental programmed cell death
relationship: part_of GO:0009653 ! anatomical structure morphogenesis

[Term]
id: GO:0060562
name: epithelial tube morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a tube are generated and organized from an epithelium. Morphogenesis pertains to the creation of form. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
is_a: GO:0035239 ! tube morphogenesis

[Term]
id: GO:0060563
name: neuroepithelial cell differentiation
namespace: biological_process
def: "The process by which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, GOC:tb]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0060564
name: negative regulation of anaphase-promoting complex activity during mitotic cell cycle
namespace: biological_process
def: "Any process that decreases the rate frequency or extent of anaphase-promoting complex activity regulating the mitotic cell cycle." [GOC:dph, GOC:tb]
synonym: "negative regulation of APC activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
synonym: "negative regulation of APC/C activity during mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "negative regulation of cyclosome activity during mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0045841 ! negative regulation of mitotic metaphase/anaphase transition
is_a: GO:0051436 ! negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle
relationship: negatively_regulates GO:0031145 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

[Term]
id: GO:0060565
name: inhibition of anaphase-promoting complex activity during mitotic cell cycle
namespace: biological_process
def: "Any process that prevents the activation of anaphase-promoting complex activity regulating the mitotic cell cycle." [GOC:dph, GOC:tb]
synonym: "inhibition of APC activity during mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of APC/C activity during mitotic cell cycle" EXACT [GOC:dph, GOC:tb]
synonym: "inhibition of cyclosome activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb]
is_a: GO:0060564 ! negative regulation of anaphase-promoting complex activity during mitotic cell cycle

[Term]
id: GO:0060566
name: positive regulation of transcription termination
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of transcription termination. Transcription termination is the process by which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:dph, GOC:tb]
is_a: GO:0031554 ! regulation of transcription termination
is_a: GO:0043243 ! positive regulation of protein complex disassembly
is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent
relationship: positively_regulates GO:0006353 ! transcription termination

[Term]
id: GO:0060567
name: negative regulation of transcription termination
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of transcription termination. Transcription termination is the process by which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:dph, GOC:tb]
is_a: GO:0031554 ! regulation of transcription termination
is_a: GO:0043242 ! negative regulation of protein complex disassembly
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent
relationship: negatively_regulates GO:0006353 ! transcription termination

[Term]
id: GO:0060568
name: regulation of peptide hormone processing
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb]
is_a: GO:0010953 ! regulation of protein maturation by peptide bond cleavage
is_a: GO:0032350 ! regulation of hormone metabolic process
relationship: regulates GO:0016486 ! peptide hormone processing

[Term]
id: GO:0060569
name: positive regulation of peptide hormone processing
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb]
is_a: GO:0010954 ! positive regulation of protein maturation by peptide bond cleavage
is_a: GO:0032352 ! positive regulation of hormone metabolic process
is_a: GO:0060568 ! regulation of peptide hormone processing
relationship: positively_regulates GO:0016486 ! peptide hormone processing

[Term]
id: GO:0060570
name: negative regulation of peptide hormone processing
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb]
is_a: GO:0010955 ! negative regulation of protein maturation by peptide bond cleavage
is_a: GO:0032351 ! negative regulation of hormone metabolic process
is_a: GO:0060568 ! regulation of peptide hormone processing
relationship: negatively_regulates GO:0016486 ! peptide hormone processing

[Term]
id: GO:0060571
name: morphogenesis of an epithelial fold
namespace: biological_process
def: "The morphogenetic process by which an epithelial sheet bends along a linear axis." [GOC:dph]
synonym: "epithelial folding" EXACT [GOC:dph]
synonym: "folding of an epithelial sheet" RELATED [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium

[Term]
id: GO:0060572
name: morphogenesis of an epithelial bud
namespace: biological_process
def: "The morphogenetic process by which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding." [GOC:dph]
is_a: GO:0060571 ! morphogenesis of an epithelial fold

[Term]
id: GO:0060573
name: cell fate specification involved in pattern specification
namespace: biological_process
def: "The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:dph, GOC:tb]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0060581 ! cell fate commitment involved in pattern specification

[Term]
id: GO:0060574
name: intestinal epithelial cell maturation
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus." [GOC:dph, PMID:18824147]
is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation
relationship: part_of GO:0060576 ! intestinal epithelial cell development

[Term]
id: GO:0060575
name: intestinal epithelial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine." [GOC:dph]
is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation

[Term]
id: GO:0060576
name: intestinal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0002066 ! columnar/cuboidal epithelial cell development
relationship: part_of GO:0060575 ! intestinal epithelial cell differentiation

[Term]
id: GO:0060577
name: pulmonary vein morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart." [GOC:dph]
synonym: "pulmonary venous blood vessel morphogenesis" RELATED [GOC:dph]
is_a: GO:0048845 ! venous blood vessel morphogenesis

[Term]
id: GO:0060578
name: superior vena cava morphogenesis
namespace: biological_process
def: "The process by which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart." [GOC:dph]
is_a: GO:0048845 ! venous blood vessel morphogenesis

[Term]
id: GO:0060579
name: ventral spinal cord interneuron fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses." [GOC:dph]
is_a: GO:0048663 ! neuron fate commitment
relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning
relationship: part_of GO:0021514 ! ventral spinal cord interneuron differentiation

[Term]
id: GO:0060580
name: ventral spinal cord interneuron fate determination
namespace: biological_process
def: "The process whereby a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron regardless of its environment; upon determination, the cell fate cannot be reversed. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses." [GOC:dph]
is_a: GO:0048664 ! neuron fate determination
relationship: part_of GO:0060579 ! ventral spinal cord interneuron fate commitment

[Term]
id: GO:0060581
name: cell fate commitment involved in pattern specification
namespace: biological_process
def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type." [GOC:dph]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0007389 ! pattern specification process

[Term]
id: GO:0060582
name: cell fate determination involved in pattern specification
namespace: biological_process
def: "A process involved in commitment of a cell to a fate in a developmental field. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:dph]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0060581 ! cell fate commitment involved in pattern specification

[Term]
id: GO:0060583
name: regulation of actin cortical patch localization
namespace: biological_process
def: "Any process that modulates the localization of an actin cortical patch. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells." [GOC:dph, GOC:tb]
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0051666 ! actin cortical patch localization

[Term]
id: GO:0060584
name: regulation of prostaglandin-endoperoxide synthase activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of prostaglandin-endoperoxidase activity. Prostaglandin-endoperoxidase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051341 ! regulation of oxidoreductase activity

[Term]
id: GO:0060585
name: positive regulation of prostaglandin-endoperoxidase synthase activity
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of prostaglandin-endoperoxidase activity. Prostaglandin-endoperoxidase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051353 ! positive regulation of oxidoreductase activity
is_a: GO:0060584 ! regulation of prostaglandin-endoperoxide synthase activity

[Term]
id: GO:0060586
name: multicellular organismal iron ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of the distribution of iron stores within tissues and organs of a multicellular organism." [GOC:dph, GOC:hjd, GOC:tb]
is_a: GO:0048871 ! multicellular organismal homeostasis
is_a: GO:0055072 ! iron ion homeostasis

[Term]
id: GO:0060587
name: regulation of lipoprotein lipid oxidation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid moiety." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0019216 ! regulation of lipid metabolic process
is_a: GO:0034442 ! regulation of lipoprotein oxidation
relationship: regulates GO:0034439 ! lipoprotein lipid oxidation

[Term]
id: GO:0060588
name: negative regulation of lipoprotein lipid oxidation
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid moiety." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0034443 ! negative regulation of lipoprotein oxidation
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0060587 ! regulation of lipoprotein lipid oxidation
relationship: negatively_regulates GO:0034439 ! lipoprotein lipid oxidation

[Term]
id: GO:0060589
name: nucleoside-triphosphatase regulator activity
namespace: molecular_function
def: "Modulates the rate of NTP hydrolysis by a NTPase." [GOC:dph, GOC:tb]
synonym: "NTPase regulator activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0060590
name: ATPase regulator activity
namespace: molecular_function
def: "Modulates the rate of ATP hydrolysis by an ATPase." [GOC:dph, GOC:tb]
is_a: GO:0060589 ! nucleoside-triphosphatase regulator activity

[Term]
id: GO:0060591
name: chondroblast differentiation
namespace: biological_process
def: "The process whereby a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes." [GOC:dph]
synonym: "chondrocyte progenitor cell differentiation" RELATED [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0051216 ! cartilage development

[Term]
id: GO:0060592
name: mammary gland formation
namespace: biological_process
def: "The process pertaining to the initial formation of the mammary gland from unspecified parts. The process begins with formation of the mammary line and ends when the solid mammary bud invades the primary mammary mesenchyme." [GOC:dph, PMID:16168142, PMID:17120154]
synonym: "mammary bud formation" RELATED [GOC:dph]
synonym: "mammary line formation" NARROW [GOC:dph]
synonym: "mammary placode formation" NARROW [GOC:dph]
synonym: "mammary sprout formation" RELATED [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060443 ! mammary gland morphogenesis

[Term]
id: GO:0060593
name: Wnt receptor signaling pathway involved in mammary gland specification
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of al cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph, PMID:16168142]
is_a: GO:0060070 ! Wnt receptor signaling pathway through beta-catenin
relationship: part_of GO:0060594 ! mammary gland specification

[Term]
id: GO:0060594
name: mammary gland specification
namespace: biological_process
def: "The regionalization process by which the mammary line is specified. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph]
synonym: "mammary line specification" RELATED [GOC:dph]
is_a: GO:0010092 ! specification of organ identity
is_a: GO:0060592 ! mammary gland formation

[Term]
id: GO:0060595
name: fibroblast growth factor receptor signaling pathway involved in mammary gland specification
namespace: biological_process
def: "The series of molecular signals initiated by binding of a fibroblast growth factor to its receptor on the surface of al cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph, PMID:16168142]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0060594 ! mammary gland specification

[Term]
id: GO:0060596
name: mammary placode formation
namespace: biological_process
def: "The developmental process by which the mammary placode forms. The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper." [GOC:dph, PMID:16168142]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0060592 ! mammary gland formation

[Term]
id: GO:0060597
name: regulation of transcription from RNA polymerase II promoter involved in mammary gland formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the formation of the mammary line, placode or bud." [GOC:dph, PMID:16168142]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0060592 ! mammary gland formation

[Term]
id: GO:0060598
name: dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
namespace: biological_process
def: "The process whereby the terminal end of a mammary duct bifurcates." [GOC:dph, PMID:17120154]
synonym: "primary mammary duct branching " EXACT [GOC:dph]
is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
relationship: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis

[Term]
id: GO:0060599
name: lateral sprouting involved in mammary gland duct morphogenesis
namespace: biological_process
def: "The process whereby a branch forms along the side of a mammary duct." [GOC:dph, PMID:17120154]
synonym: "mammary gland duct secondary branching" EXACT [GOC:dph]
is_a: GO:0060601 ! lateral sprouting from an epithelium
relationship: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis

[Term]
id: GO:0060600
name: dichotomous subdivision of an epithelial terminal unit
namespace: biological_process
def: "The process whereby an epithelial cord, rod or tube bifurcates at its end." [GOC:dph]
synonym: "primary branching of an epithelium" RELATED [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0001763 ! morphogenesis of a branching structure

[Term]
id: GO:0060601
name: lateral sprouting from an epithelium
namespace: biological_process
def: "The process whereby a branch forms along the side of an epithelium." [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0001763 ! morphogenesis of a branching structure

[Term]
id: GO:0060602
name: branch elongation of an epithelium
namespace: biological_process
def: "The growth process by which a branch increases in length from its base to its tip." [GOC:dph]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0001763 ! morphogenesis of a branching structure

[Term]
id: GO:0060603
name: mammary gland duct morphogenesis
namespace: biological_process
def: "The process by which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk." [GOC:dph, PMID:17120154]
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0060443 ! mammary gland morphogenesis

[Term]
id: GO:0060604
name: mammary gland duct cavitation
namespace: biological_process
def: "Creation of the central hole of the mammary gland duct by the hollowing out of a solid rod." [GOC:dph, PMID:17120154]
synonym: "milk duct cavitation" RELATED [GOC:dph]
is_a: GO:0060605 ! tube lumen cavitation
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis

[Term]
id: GO:0060605
name: tube lumen cavitation
namespace: biological_process
def: "The formation of a lumen by hollowing out a solid rod or cord." [GOC:dph]
is_a: GO:0035148 ! tube formation

[Term]
id: GO:0060606
name: tube closure
namespace: biological_process
def: "Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold." [GOC:dph]
is_a: GO:0035148 ! tube formation

[Term]
id: GO:0060607
name: cell-cell adhesion involved in sealing an epithelial fold
namespace: biological_process
def: "The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of an epithelial tube." [GOC:dph]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0060606 ! tube closure

[Term]
id: GO:0060608
name: cell-cell adhesion involved in neural tube closure
namespace: biological_process
def: "The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of the neural tube." [GOC:dph]
is_a: GO:0060607 ! cell-cell adhesion involved in sealing an epithelial fold
relationship: part_of GO:0001843 ! neural tube closure

[Term]
id: GO:0060609
name: apoptosis involved in tube lumen cavitation
namespace: biological_process
def: "The process of apoptosis that contributes to the hollowing out of an epithelial rod or cord to form the central hole in a tube." [GOC:dph]
is_a: GO:0060561 ! apoptosis involved in morphogenesis
relationship: part_of GO:0060605 ! tube lumen cavitation

[Term]
id: GO:0060610
name: mesenchymal cell differentiation involved in mammary gland development
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a mammary gland mesenchymal cell. Mammary gland mesenchymal cells form a loosely connected network of cells that surround the mammary ducts." [GOC:dph]
synonym: "mammary gland mesenchymal cell differentiation" EXACT [GOC:dph]
is_a: GO:0048762 ! mesenchymal cell differentiation
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0060611
name: mammary gland fat development
namespace: biological_process
def: "The progression of the mammary gland fat over time, from its formation to the mature structure. The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts." [GOC:dph]
is_a: GO:0060612 ! adipose tissue development
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0060612
name: adipose tissue development
namespace: biological_process
def: "The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat." [GOC:dph]
synonym: "adipogenesis" RELATED [GOC:mah, GOC:sl]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0060613
name: fat pad development
namespace: biological_process
def: "The progression of a fat pad from its initial formation to its mature structure. A fat pad is an accumulation of adipose tissue." [GOC:dph]
is_a: GO:0060612 ! adipose tissue development

[Term]
id: GO:0060614
name: negative regulation of mammary gland development in males by androgen receptor signaling pathway
namespace: biological_process
def: "Any process that decreases the rate or extent of mammary gland development in the male by an androgen binding to its receptor, causing a change in state or activity of a cell." [GOC:dph]
is_a: GO:0030521 ! androgen receptor signaling pathway
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: negatively_regulates GO:0030879 ! mammary gland development

[Term]
id: GO:0060615
name: mammary gland bud formation
namespace: biological_process
def: "The morphogenetic process by which a bud forms from the mammary placode. A mammary bud is bulb of epithelial cells that is distinct from the surrounding epidermis." [GOC:dph, PMID:12558599]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060648 ! mammary gland bud morphogenesis

[Term]
id: GO:0060616
name: mammary gland cord formation
namespace: biological_process
def: "The process by which the mammary gland cord forms by elongation of the mammary bud. The cord is formed once the elongating bud breaks through the mesenchyme and reaches the fat pad." [GOC:dph, PMID:12558599]
synonym: "mammary gland sprout formation" EXACT [GOC:dph]
is_a: GO:0016331 ! morphogenesis of embryonic epithelium
relationship: part_of GO:0060652 ! mammary gland cord morphogenesis

[Term]
id: GO:0060617
name: positive regulation of mammary placode formation by mesenchymal-epithelial signaling
namespace: biological_process
def: "Any process that initiates the formation of a mammary placode through a mechanism that mediates the transfer of information from a mesenchymal cell to an epithelial cell resulting in the epithelial cell adopting the identity of a cell of the mammary placode." [GOC:dph, PMID:12558599]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
relationship: positively_regulates GO:0060596 ! mammary placode formation

[Term]
id: GO:0060618
name: nipple development
namespace: biological_process
def: "The progression of the nipple over time, from its formation to the mature structure. The nipple is a part of the mammary gland that protrudes from the surface ectoderm." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0060619
name: cell migration involved in mammary placode formation
namespace: biological_process
def: "The orderly movement of epithelial cells within the mammary line that contributes to the formation of the mammary placode." [GOC:dph, PMID:12558599]
is_a: GO:0010631 ! epithelial cell migration
relationship: part_of GO:0060596 ! mammary placode formation

[Term]
id: GO:0060620
name: regulation of cholesterol import
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032374 ! regulation of cholesterol transport
relationship: regulates GO:0070508 ! cholesterol import

[Term]
id: GO:0060621
name: negative regulation of cholesterol import
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032375 ! negative regulation of cholesterol transport
is_a: GO:0060620 ! regulation of cholesterol import
relationship: negatively_regulates GO:0070508 ! cholesterol import

[Term]
id: GO:0060622
name: regulation of ascospore wall beta-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of ascospore wall beta-glucan biosynthetic process, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:dph, GOC:tb]
is_a: GO:0034307 ! regulation of ascospore formation
is_a: GO:0090093 ! regulation of fungal-type cell wall beta-glucan biosynthetic process
relationship: regulates GO:0034412 ! ascospore wall beta-glucan biosynthetic process

[Term]
id: GO:0060623
name: regulation of chromosome condensation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:dph, GOC:tb]
is_a: GO:0033044 ! regulation of chromosome organization
relationship: regulates GO:0030261 ! chromosome condensation

[Term]
id: GO:0060624
name: regulation of ascospore wall 1,3-beta-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of ascospore wall 1,3-beta-glucan biosynthetic process, the chemical reactions and pathways resulting in the formation of 1,3-beta-glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:dph, GOC:tb]
is_a: GO:0032953 ! regulation of 1,3-beta-glucan biosynthetic process
is_a: GO:0060622 ! regulation of ascospore wall beta-glucan biosynthetic process
relationship: regulates GO:0034413 ! ascospore wall 1,3-beta-glucan biosynthetic process

[Term]
id: GO:0060625
name: regulation of protein deneddylation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of protein deneddylation, the removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:dph, GOC:tb]
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0000338 ! protein deneddylation

[Term]
id: GO:0060626
name: regulation of cullin deneddylation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cullin deneddylation, the modification of cullins by removal of ubiquitin-like protein NEDD8 (RUB1)." [GOC:dph, GOC:tb]
is_a: GO:0060625 ! regulation of protein deneddylation
relationship: regulates GO:0010388 ! cullin deneddylation

[Term]
id: GO:0060627
name: regulation of vesicle-mediated transport
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0016192 ! vesicle-mediated transport

[Term]
id: GO:0060628
name: regulation of ER to Golgi vesicle-mediated transport
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:dph, GOC:tb]
is_a: GO:0032386 ! regulation of intracellular transport
is_a: GO:0060627 ! regulation of vesicle-mediated transport
relationship: regulates GO:0006888 ! ER to Golgi vesicle-mediated transport

[Term]
id: GO:0060629
name: regulation of homologous chromosome segregation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of homologous chromosome segregation, the cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:dph, GOC:tb]
is_a: GO:0051983 ! regulation of chromosome segregation
is_a: GO:0060631 ! regulation of meiosis I
relationship: regulates GO:0045143 ! homologous chromosome segregation

[Term]
id: GO:0060630
name: regulation of M/G1 transition of mitotic cell cycle
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of M/G1 transition of the mitotic cell cycle, the progression from M phase to G1 phase of the mitotic cell cycle." [GOC:dph, GOC:tb]
is_a: GO:0007346 ! regulation of mitotic cell cycle
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0000216 ! M/G1 transition of mitotic cell cycle

[Term]
id: GO:0060631
name: regulation of meiosis I
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:tb]
is_a: GO:0040020 ! regulation of meiosis
relationship: regulates GO:0007127 ! meiosis I

[Term]
id: GO:0060632
name: regulation of microtubule-based movement
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb]
is_a: GO:0032886 ! regulation of microtubule-based process
relationship: regulates GO:0007018 ! microtubule-based movement

[Term]
id: GO:0060633
name: negative regulation of transcription initiation from RNA polymerase II promoter
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of a process involved in starting transcription from the RNA polymerase II promoter." [GOC:dph, GOC:tb]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0031333 ! negative regulation of protein complex assembly
is_a: GO:0051253 ! negative regulation of RNA metabolic process
is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter
relationship: negatively_regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter

[Term]
id: GO:0060634
name: regulation of 4,6-pyruvylated galactose residue biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of 4,6-pyruvylated galactose residue biosynthetic process, the chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:dph, GOC:tb]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process
relationship: regulates GO:0051072 ! 4,6-pyruvylated galactose residue biosynthetic process

[Term]
id: GO:0060635
name: positive regulation of 1,3-beta-glucan biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta-1,3 glucans." [GOC:dph, GOC:tb]
is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0032953 ! regulation of 1,3-beta-glucan biosynthetic process
relationship: positively_regulates GO:0006075 ! 1,3-beta-glucan biosynthetic process

[Term]
id: GO:0060636
name: negative regulation of 1,3-beta-glucan biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta-1,3 glucans." [GOC:dph, GOC:tb]
is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0032953 ! regulation of 1,3-beta-glucan biosynthetic process
relationship: negatively_regulates GO:0006075 ! 1,3-beta-glucan biosynthetic process

[Term]
id: GO:0060637
name: positive regulation of lactation by mesenchymal-epithelial cell signaling
namespace: biological_process
def: "The process that increases the rate, frequency, or extent of lactation as a result of the secretion of a signal from the mammary fat and its reception by a mammary epithelial cell." [GOC:dph, PMID:12558599]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
relationship: positively_regulates GO:0007595 ! lactation

[Term]
id: GO:0060638
name: mesenchymal-epithelial cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted." [GOC:dph]
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0060639
name: positive regulation of salivary gland formation by mesenchymal-epithelial signaling
namespace: biological_process
def: "Any process that induces the formation of the salivary gland field by means of the secretion of a signal by a mesenchymal cell and its reception and interpretation by an epithelial cell resulting in it adopting the identity of a salivary gland bud cell." [GOC:dph]
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
relationship: positively_regulates GO:0007435 ! salivary gland morphogenesis

[Term]
id: GO:0060640
name: positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signaling
namespace: biological_process
def: "Any process that initiates the formation of a tooth bud by the secretion of a signal from a mesenchymal cell and its reception and subsequent change in the identity of an epithelial cell of the tooth bud." [GOC:dph]
is_a: GO:0042488 ! positive regulation of odontogenesis of dentine-containing tooth
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling

[Term]
id: GO:0060641
name: mammary gland duct regression in males
namespace: biological_process
def: "The process by which the epithelium of the mammary duct is destroyed in males." [GOC:dph, PMID:12558599]
is_a: GO:0060033 ! anatomical structure regression
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis

[Term]
id: GO:0060642
name: white fat cell differentiation involved in mammary gland fat development
namespace: biological_process
def: "The process whereby a preadipocyte acquires specialized features of a white adipocyte of the mammary gland. White adipocytes have cytoplasmic lipids arranged in a unique vacuole." [GOC:dph, PMID:12558599]
is_a: GO:0050872 ! white fat cell differentiation
relationship: part_of GO:0060611 ! mammary gland fat development

[Term]
id: GO:0060643
name: epithelial cell differentiation involved in mammary gland bud morphogenesis
namespace: biological_process
def: "The process by which a cell of the mammary placode becomes a cell of the mammary gland bud." [GOC:dph]
is_a: GO:0060644 ! mammary gland epithelial cell differentiation
relationship: part_of GO:0060615 ! mammary gland bud formation

[Term]
id: GO:0060644
name: mammary gland epithelial cell differentiation
namespace: biological_process
def: "The process by which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland." [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0060645
name: peripheral mammary gland bud epithelial cell differentiation
namespace: biological_process
def: "The process by which a relatively unspecialized epithelial cell of the mammary placode becomes an epithelial cell at the periphery of the mammary gland bud. Cells at the periphery of the bud are larger that those of the surrounding epithelium and are arranged concentrically." [GOC:dph, PMID:12558599]
is_a: GO:0060643 ! epithelial cell differentiation involved in mammary gland bud morphogenesis

[Term]
id: GO:0060646
name: internal mammary gland bud epithelial cell differentiation
namespace: biological_process
def: "The process by which a relatively unspecialized epithelial cell of the mammary placode becomes an internal epithelial cell of the mammary gland bud. Internal cells are small and of irregular shape." [GOC:dph, PMID:12558599]
is_a: GO:0060643 ! epithelial cell differentiation involved in mammary gland bud morphogenesis

[Term]
id: GO:0060647
name: mesenchymal cell condensation involved in mammary fat development
namespace: biological_process
def: "The cell adhesion process by which mammary mesenchyme cells adhere to one another in the initial stages of the formation of mammary fat development." [GOC:dph, PMID:12558599]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0060611 ! mammary gland fat development

[Term]
id: GO:0060648
name: mammary gland bud morphogenesis
namespace: biological_process
def: "The process by which anatomical structures of the mammary gland buds are generated and organized. Mammary gland buds form by an outpocketing of the mammary placodes and grow to invade the mammary fat, when they form the mammary cord." [GOC:dph, PMID:12558599]
is_a: GO:0060572 ! morphogenesis of an epithelial bud
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis

[Term]
id: GO:0060649
name: mammary gland bud elongation
namespace: biological_process
def: "The process by which the mammary gland bud grows along its axis." [GOC:dph, PMID:12558599]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060648 ! mammary gland bud morphogenesis

[Term]
id: GO:0060650
name: epithelial cell proliferation involved in mammary gland bud elongation
namespace: biological_process
def: "The multiplication or reproduction of mammary gland bud epithelial cells, resulting in the elongation of the bud." [GOC:dph, PMID:12558599]
is_a: GO:0033598 ! mammary gland epithelial cell proliferation
relationship: part_of GO:0060649 ! mammary gland bud elongation

[Term]
id: GO:0060651
name: regulation of epithelial cell proliferation involved in mammary gland bud elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mammary gland bud epithelial cell proliferation that results in the elongation of the bud." [GOC:dph, PMID:12558599]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation
is_a: GO:0048638 ! regulation of developmental growth
relationship: regulates GO:0060650 ! epithelial cell proliferation involved in mammary gland bud elongation

[Term]
id: GO:0060652
name: mammary gland cord morphogenesis
namespace: biological_process
def: "The process by which anatomical structures of the mammary gland cord are generated and organized. Mammary gland cords form when the mammary gland bud invades the mammary fat." [GOC:dph, PMID:12558599]
synonym: "mammary gland sprout morphogenesis" EXACT [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis

[Term]
id: GO:0060653
name: epithelial cell differentiation involved in mammary gland cord morphogenesis
namespace: biological_process
def: "The process by which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland cord. Epithelial cells of the mammary cord give it its funnel-like shape and some are cornified." [GOC:dph, PMID:12558599]
synonym: "epithelial cell differentiation involved in mammary gland sprout morphogenesis" RELATED [GOC:dph]
is_a: GO:0060644 ! mammary gland epithelial cell differentiation
relationship: part_of GO:0060652 ! mammary gland cord morphogenesis

[Term]
id: GO:0060654
name: mammary gland cord elongation
namespace: biological_process
def: "The process by which the mammary gland sprout grows along its axis." [GOC:dph, PMID:12558599]
is_a: GO:0060602 ! branch elongation of an epithelium
relationship: part_of GO:0060652 ! mammary gland cord morphogenesis

[Term]
id: GO:0060655
name: branching involved in mammary gland cord morphogenesis
namespace: biological_process
def: "The process by which the branching structure of the mammary gland cord is generated and organized. The mammary gland cord is a solid epithelial structure that will hollow out, forming the mammary duct." [GOC:dph, PMID:12558599]
is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis
relationship: part_of GO:0060652 ! mammary gland cord morphogenesis

[Term]
id: GO:0060656
name: regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching of the mammary gland cord as a result of a signal being created by a mammary fat precursor cell and its subsequent reception and interpretation by a mammary cord epithelial cell." [GOC:dph, PMID:12558599]
is_a: GO:0007267 ! cell-cell signaling
is_a: GO:0060762 ! regulation of branching involved in mammary gland duct morphogenesis
relationship: regulates GO:0060655 ! branching involved in mammary gland cord morphogenesis

[Term]
id: GO:0060657
name: regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of mammary gland cord elongation as a result of a signal being created by a mesenchymal cell that is a precursor to the mammary fat and its subsequent reception and interpretation by an mammary cord epithelial cell." [GOC:dph, PMID:12558599]
is_a: GO:0007267 ! cell-cell signaling
relationship: regulates GO:0060654 ! mammary gland cord elongation

[Term]
id: GO:0060658
name: nipple morphogenesis
namespace: biological_process
def: "The process by which the nipple is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060618 ! nipple development

[Term]
id: GO:0060659
name: nipple sheath formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the nipple sheath from the unspecified epidermis. This process begins with a circular ingrowth of the epidermis around the region of the mammary sprout. It ends before the region begins to elevate." [GOC:dph, PMID:12558599]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060658 ! nipple morphogenesis

[Term]
id: GO:0060660
name: epidermis morphogenesis involved in nipple formation
namespace: biological_process
def: "The process by which the epidermis of the nipple sheath is uplifted to form an umbrella-like projection." [GOC:dph, PMID:12558599]
is_a: GO:0048730 ! epidermis morphogenesis
relationship: part_of GO:0060658 ! nipple morphogenesis

[Term]
id: GO:0060661
name: submandibular salivary gland formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a submandibular salivary gland. This process begins with a thickening of the epithelium next to the tongue and ends when a bud linked to the oral surface is formed." [GOC:dph, PMID:17336109]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0007435 ! salivary gland morphogenesis

[Term]
id: GO:0060662
name: salivary gland cavitation
namespace: biological_process
def: "The process by which the solid core of salivary epithelium gives rise to the hollow tube of the gland." [GOC:dph]
is_a: GO:0060605 ! tube lumen cavitation
relationship: part_of GO:0007435 ! salivary gland morphogenesis

[Term]
id: GO:0060663
name: apoptosis involved in salivary gland cavitation
namespace: biological_process
def: "The apoptosis process in which the solid core of the gland is hollowed out to form the duct." [GOC:dph, PMID:17336109]
is_a: GO:0060561 ! apoptosis involved in morphogenesis
relationship: part_of GO:0060662 ! salivary gland cavitation

[Term]
id: GO:0060664
name: epithelial cell proliferation involved in salivary gland morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland." [GOC:dph, PMID:17336109]
is_a: GO:0007435 ! salivary gland morphogenesis
is_a: GO:0050673 ! epithelial cell proliferation

[Term]
id: GO:0060665
name: regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching involved in salivary gland morphogenesis as a result of signals being generated by the mesenchyme and received and interpreted by the salivary gland epithelium." [GOC:dph, PMID:17336109]
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis

[Term]
id: GO:0060666
name: dichotomous subdivision of terminal units involved in salivary gland branching
namespace: biological_process
def: "The process whereby a salivary epithelial cord bifurcates at its end." [GOC:dph]
is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
relationship: part_of GO:0060445 ! branching involved in salivary gland morphogenesis

[Term]
id: GO:0060667
name: branch elongation involved in salivary gland morphogenesis
namespace: biological_process
def: "The differential growth of the salivary branches along their axis, resulting in the growth of a branch." [GOC:dph]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060445 ! branching involved in salivary gland morphogenesis

[Term]
id: GO:0060668
name: regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the extracellular matrix to the epithelium of the salivary gland." [GOC:dph]
is_a: GO:0007154 ! cell communication
is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis

[Term]
id: GO:0060669
name: embryonic placenta morphogenesis
namespace: biological_process
def: "The process by which the embryonic placenta is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph]
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0001892 ! embryonic placenta development

[Term]
id: GO:0060670
name: branching involved in embryonic placenta morphogenesis
namespace: biological_process
def: "The process by which the branches of the fetal placental villi are generated and organized. Morphogenesis pertains to the creation of form. The villous part of the placenta is called the labyrinth layer." [GOC:dph, PMID:16916377]
is_a: GO:0001763 ! morphogenesis of a branching structure
is_a: GO:0048598 ! embryonic morphogenesis
relationship: part_of GO:0060669 ! embryonic placenta morphogenesis
relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis

[Term]
id: GO:0060671
name: epithelial cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "The process whereby a trophoblast cell acquires specialized features of an epithelial cell of the placental labyrinthine layer." [GOC:dph, PMID:16916377]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development
relationship: part_of GO:0060711 ! labyrinthine layer development

[Term]
id: GO:0060672
name: epithelial cell morphogenesis involved in placental branching
namespace: biological_process
def: "The change in form (cell shape and size) that occurs when a trophoblast cell elongates to contribute to the branching of the placenta." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:16916377]
is_a: GO:0003382 ! epithelial cell morphogenesis
is_a: GO:0060671 ! epithelial cell differentiation involved in embryonic placenta development
relationship: part_of GO:0060670 ! branching involved in embryonic placenta morphogenesis

[Term]
id: GO:0060673
name: cell-cell signaling involved in placenta development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another." [GOC:dph, PMID:16916377]
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0001892 ! embryonic placenta development

[Term]
id: GO:0060674
name: placenta blood vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure." [GOC:dph, PMID:16916377]
is_a: GO:0001568 ! blood vessel development
relationship: part_of GO:0001890 ! placenta development

[Term]
id: GO:0060675
name: ureteric bud morphogenesis
namespace: biological_process
def: "The process by which the ureteric bud is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0001657 ! ureteric bud development

[Term]
id: GO:0060676
name: ureteric bud formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. This process begins when the bud protrudes from the duct and ends when it is a recognizable bud." [GOC:dph, PMID:16916378]
is_a: GO:0001838 ! embryonic epithelial tube formation
relationship: part_of GO:0060675 ! ureteric bud morphogenesis

[Term]
id: GO:0060677
name: ureteric bud elongation
namespace: biological_process
def: "The process by which the ureteric bud grows along its axis." [GOC:dph, PMID:16916378]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060675 ! ureteric bud morphogenesis

[Term]
id: GO:0060678
name: dichotomous subdivision of terminal units involved in ureteric bud branching
namespace: biological_process
def: "The process whereby a ureteric bud bifurcates at its end." [GOC:dph, PMID:16916378]
synonym: "bifid subdivision of terminal units involved in ureteric bud branching" EXACT [GOC:dph, PMID:16916378]
is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit
relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis

[Term]
id: GO:0060679
name: trifid subdivision of terminal units involved in ureteric bud branching
namespace: biological_process
def: "The process whereby a ureteric bud splits into three units at its end." [GOC:dph, PMID:16916378]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis

[Term]
id: GO:0060680
name: lateral sprouting involved in ureteric bud morphogenesis
namespace: biological_process
def: "The process whereby a branch forms along the side of a ureteric bud." [GOC:dph, PMID:16916378]
is_a: GO:0060601 ! lateral sprouting from an epithelium
relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis

[Term]
id: GO:0060681
name: branch elongation involved in ureteric bud branching
namespace: biological_process
def: "The growth of a branch of the ureteric bud along its axis." [GOC:dph, PMID:16916378]
is_a: GO:0060602 ! branch elongation of an epithelium
is_a: GO:0060677 ! ureteric bud elongation
relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis

[Term]
id: GO:0060682
name: primary ureteric bud growth
namespace: biological_process
def: "The process by which the primary ureteric bud grows along its axis dorsally toward the metanephric blastema." [GOC:dph, PMID:16916378]
is_a: GO:0060677 ! ureteric bud elongation

[Term]
id: GO:0060683
name: regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the epithelial cells to the mesenchymal cells of the salivary gland." [GOC:dph, PMID:18559345]
is_a: GO:0060684 ! epithelial-mesenchymal cell signaling
is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis

[Term]
id: GO:0060684
name: epithelial-mesenchymal cell signaling
namespace: biological_process
def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted." [GOC:dph]
is_a: GO:0007267 ! cell-cell signaling

[Term]
id: GO:0060685
name: regulation of prostatic bud formation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of prostatic bud formation, the morphogenetic process whereby a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph]
is_a: GO:0003156 ! regulation of organ formation
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
relationship: regulates GO:0060513 ! prostatic bud formation

[Term]
id: GO:0060686
name: negative regulation of prostatic bud formation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of prostatic bud formation, the morphogenetic process whereby a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0060685 ! regulation of prostatic bud formation

[Term]
id: GO:0060687
name: regulation of branching involved in prostate gland morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of prostate gland branching, the process by which the branching structure of the prostate gland is generated and organized. Morphogenesis pertains to the creation of form. A branch is a division or offshoot from a main stem." [GOC:dph]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
relationship: regulates GO:0060442 ! branching involved in prostate gland morphogenesis

[Term]
id: GO:0060688
name: regulation of morphogenesis of a branching structure
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process by which the anatomical structures of branches are generated and organized." [GOC:dph]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0001763 ! morphogenesis of a branching structure

[Term]
id: GO:0060689
name: cell differentiation involved in salivary gland development
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the cells of the salivary gland." [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0007431 ! salivary gland development

[Term]
id: GO:0060690
name: epithelial cell differentiation involved in salivary gland development
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquire specialized structural and/or functional features of an epithelial cell of the salivary gland." [GOC:dph]
is_a: GO:0060689 ! cell differentiation involved in salivary gland development

[Term]
id: GO:0060691
name: epithelial cell maturation involved in salivary gland development
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the salivary gland to attain its fully functional state." [GOC:dph]
is_a: GO:0002070 ! epithelial cell maturation
relationship: part_of GO:0060690 ! epithelial cell differentiation involved in salivary gland development

[Term]
id: GO:0060692
name: mesenchymal cell differentiation involved in salivary gland development
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the salivary gland. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph]
is_a: GO:0048762 ! mesenchymal cell differentiation
is_a: GO:0060689 ! cell differentiation involved in salivary gland development

[Term]
id: GO:0060693
name: regulation of branching involved in salivary gland morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium." [GOC:dph]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
relationship: regulates GO:0060445 ! branching involved in salivary gland morphogenesis

[Term]
id: GO:0060694
name: regulation of cholesterol transporter activity
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cholesterol transporter activity." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0022898 ! regulation of transmembrane transporter activity
is_a: GO:0032374 ! regulation of cholesterol transport

[Term]
id: GO:0060695
name: negative regulation of cholesterol transporter activity
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cholesterol transporter activity." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032375 ! negative regulation of cholesterol transport
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:0060694 ! regulation of cholesterol transporter activity

[Term]
id: GO:0060696
name: regulation of phospholipid catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0050994 ! regulation of lipid catabolic process
relationship: regulates GO:0009395 ! phospholipid catabolic process

[Term]
id: GO:0060697
name: positive regulation of phospholipid catabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0050996 ! positive regulation of lipid catabolic process
is_a: GO:0060696 ! regulation of phospholipid catabolic process
relationship: positively_regulates GO:0009395 ! phospholipid catabolic process

[Term]
id: GO:0060698
name: endoribonuclease inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of an endoribonuclease, any enzyme that catalyzes the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb]
is_a: GO:0008428 ! ribonuclease inhibitor activity

[Term]
id: GO:0060699
name: regulation of endoribonuclease activity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb]
is_a: GO:0060700 ! regulation of ribonuclease activity

[Term]
id: GO:0060700
name: regulation of ribonuclease activity
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:dph, GOC:tb]
is_a: GO:0032069 ! regulation of nuclease activity

[Term]
id: GO:0060701
name: negative regulation of ribonuclease activity
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:dph, GOC:tb]
is_a: GO:0032074 ! negative regulation of nuclease activity
is_a: GO:0060700 ! regulation of ribonuclease activity

[Term]
id: GO:0060702
name: negative regulation of endoribonuclease activity
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb]
is_a: GO:0060699 ! regulation of endoribonuclease activity
is_a: GO:0060701 ! negative regulation of ribonuclease activity

[Term]
id: GO:0060703
name: deoxyribonuclease inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of deoxyribonuclease." [GOC:dph, GOC:tb]
synonym: "DNase inhibitor activity" RELATED [GOC:dph, GOC:tb]
is_a: GO:0004857 ! enzyme inhibitor activity

[Term]
id: GO:0060704
name: acinar cell differentiation involved in salivary gland development
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized structural and/or functional features that characterize an acinar cell of the salivary gland. Acinar cells are protein-secreting cells in the gland." [GOC:dph]
is_a: GO:0060689 ! cell differentiation involved in salivary gland development

[Term]
id: GO:0060705
name: neuron differentiation involved in salivary gland development
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the neurons of the salivary gland." [GOC:dph]
is_a: GO:0030182 ! neuron differentiation
is_a: GO:0060689 ! cell differentiation involved in salivary gland development

[Term]
id: GO:0060706
name: cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of the embryonic placenta." [GOC:dph]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001892 ! embryonic placenta development

[Term]
id: GO:0060707
name: trophoblast giant cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua." [GOC:dph, PMID:16269175]
is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development

[Term]
id: GO:0060708
name: spongiotrophoblast differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell of the ectoplacental cone acquires specialized features of a spongiotrophoblast of the placenta. A spongiotrophoblast cell is a basophilic cell." [GOC:dph, PMID:16269175]
is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development
relationship: part_of GO:0060712 ! spongiotrophoblast layer development

[Term]
id: GO:0060709
name: glycogen cell development involved in embryonic placenta development
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a glycogen cell of the placenta. A glycogen cell is a vacuolated glycogen-rich cell that appears in compact cell islets of the spongiotrophoblast layer." [GOC:dph, PMID:16269175]
is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development
relationship: part_of GO:0060712 ! spongiotrophoblast layer development

[Term]
id: GO:0060710
name: chorio-allantoic fusion
namespace: biological_process
def: "The cell-cell adhesion process by which the cells of the chorion fuse to the cells of the allantois." [GOC:dph]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis

[Term]
id: GO:0060711
name: labyrinthine layer development
namespace: biological_process
def: "The process by which the labyrinthine layer of the placenta progresses, from its formation to its mature state." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001892 ! embryonic placenta development

[Term]
id: GO:0060712
name: spongiotrophoblast layer development
namespace: biological_process
def: "The process by which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001892 ! embryonic placenta development

[Term]
id: GO:0060713
name: labyrinthine layer morphogenesis
namespace: biological_process
def: "The process by which the labyrinthine layer of the placenta is generated and organized." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060711 ! labyrinthine layer development

[Term]
id: GO:0060714
name: labyrinthine layer formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the labyrinthine layer of the placenta." [GOC:dph]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis

[Term]
id: GO:0060715
name: syncytiotrophoblast cell differentiation involved in labyrinthine layer development
namespace: biological_process
def: "The process whereby a chorionic trophoblast cell acquires specialized features of a syncytiotrophoblast of the labyrinthine layer of the placenta." [GOC:dph]
is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development
relationship: part_of GO:0060711 ! labyrinthine layer development

[Term]
id: GO:0060716
name: labyrinthine layer blood vessel development
namespace: biological_process
def: "The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply." [GOC:dph]
is_a: GO:0060674 ! placenta blood vessel development
relationship: part_of GO:0060711 ! labyrinthine layer development

[Term]
id: GO:0060717
name: chorion development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0060718
name: chorionic trophoblast cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [GOC:dph, PMID:16983341]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0060717 ! chorion development

[Term]
id: GO:0060719
name: chorionic trophoblast cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of chorionic trophoblast over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:16983341, GOC:dph]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0060718 ! chorionic trophoblast cell differentiation

[Term]
id: GO:0060720
name: spongiotrophoblast cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of spongiotrophoblast cells, resulting in the expansion of the population in the spongiotrophoblast layer." [GOC:dph]
is_a: GO:0060722 ! cell proliferation involved in embryonic placenta development
relationship: part_of GO:0090214 ! spongiotrophoblast layer developmental growth

[Term]
id: GO:0060721
name: regulation of spongiotrophoblast cell proliferation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of spongiotrophoblast cell proliferation." [GOC:dph]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0060723 ! regulation of cell proliferation involved in embryonic placenta development
relationship: regulates GO:0060720 ! spongiotrophoblast cell proliferation

[Term]
id: GO:0060722
name: cell proliferation involved in embryonic placenta development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the embryonic placenta." [GOC:dph]
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0001892 ! embryonic placenta development

[Term]
id: GO:0060723
name: regulation of cell proliferation involved in embryonic placenta development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cell proliferation involved in embryonic placenta development." [GOC:dph]
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0045995 ! regulation of embryonic development
relationship: regulates GO:0060722 ! cell proliferation involved in embryonic placenta development

[Term]
id: GO:0060724
name: coreceptor activity involved in epidermal growth factor receptor signaling pathway
namespace: molecular_function
def: "Combining with an extracellular messenger, and in cooperation with a primary EGF receptor, initiating a change in cell activity through the EGF receptor signaling pathway." [GOC:dph, GOC:tb]
is_a: GO:0015026 ! coreceptor activity

[Term]
id: GO:0060725
name: regulation of coreceptor activity
namespace: biological_process
def: "Any process that modulates the rate or frequency of coreceptor activity, combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:dph, GOC:tb]
is_a: GO:0010469 ! regulation of receptor activity

[Term]
id: GO:0060726
name: regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb]
synonym: "regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb]
is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway
is_a: GO:0060725 ! regulation of coreceptor activity

[Term]
id: GO:0060727
name: positive regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that increases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb]
synonym: "positive regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb]
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0060726 ! regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway

[Term]
id: GO:0060728
name: negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that decreases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb]
synonym: "negative regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0060726 ! regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway

[Term]
id: GO:0060729
name: intestinal epithelial structure maintenance
namespace: biological_process
def: "A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:BHF, GOC:dph, GOC:tb]
synonym: "epithelial structure maintenance of intestine" EXACT [GOC:dph, GOC:tb]
synonym: "maintenance of intestinal epithelium" EXACT [GOC:dph, GOC:tb]
is_a: GO:0030277 ! maintenance of gastrointestinal epithelium

[Term]
id: GO:0060730
name: regulation of intestinal epithelial structure maintenance
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0044058 ! regulation of digestive system process
relationship: regulates GO:0060729 ! intestinal epithelial structure maintenance

[Term]
id: GO:0060731
name: positive regulation of intestinal epithelial structure maintenance
namespace: biological_process
def: "Any process the increases the rate, frequency or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:dph, GOC:tb]
is_a: GO:0032846 ! positive regulation of homeostatic process
is_a: GO:0060456 ! positive regulation of digestive system process
is_a: GO:0060730 ! regulation of intestinal epithelial structure maintenance
relationship: positively_regulates GO:0060729 ! intestinal epithelial structure maintenance

[Term]
id: GO:0060732
name: positive regulation of inositol phosphate biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:dph, GOC:tb]
is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process
is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
relationship: positively_regulates GO:0032958 ! inositol phosphate biosynthetic process

[Term]
id: GO:0060733
name: regulation of eIF2 alpha phosphorylation by amino acid starvation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to amino acid starvation." [GOC:dph, GOC:tb]
is_a: GO:0001932 ! regulation of protein amino acid phosphorylation
is_a: GO:0034198 ! cellular response to amino acid starvation
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation

[Term]
id: GO:0060734
name: regulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to endoplasmic reticulum stress." [GOC:dph, GOC:tb]
synonym: "regulation of eIF2 alpha phosphorylation by ER stress" EXACT [GOC:dph, GOC:tb]
is_a: GO:0001932 ! regulation of protein amino acid phosphorylation
is_a: GO:0034976 ! response to endoplasmic reticulum stress
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation

[Term]
id: GO:0060735
name: regulation of eIF2 alpha phosphorylation by dsRNA
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to double-stranded RNA." [GOC:dph, GOC:tb]
synonym: "regulation of eIF2 alpha phosphorylation by double-stranded RNA" EXACT [GOC:dph]
synonym: "regulation of eIF2 alpha phosphorylation by PKR" NARROW [GOC:dph, GOC:tb]
is_a: GO:0001932 ! regulation of protein amino acid phosphorylation
is_a: GO:0071359 ! cellular response to dsRNA
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation

[Term]
id: GO:0060736
name: prostate gland growth
namespace: biological_process
def: "The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state." [GOC:dph]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060737
name: prostate gland morphogenetic growth
namespace: biological_process
def: "The differential increase in size or mass of the prostate gland that contributes to the gland attaining its form." [GOC:dph]
synonym: "prostate gland growth involved in morphogenesis" EXACT [GOC:dph]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
is_a: GO:0060736 ! prostate gland growth
relationship: part_of GO:0060512 ! prostate gland morphogenesis

[Term]
id: GO:0060738
name: epithelial-mesenchymal signaling involved in prostate gland development
namespace: biological_process
def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted and contributes to the progression of the prostate gland over time." [GOC:dph]
is_a: GO:0060684 ! epithelial-mesenchymal cell signaling
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060739
name: mesenchymal-epithelial cell signaling involved in prostate gland development
namespace: biological_process
def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted contributing to the progression of the prostate gland over time." [GOC:dph]
is_a: GO:0060638 ! mesenchymal-epithelial cell signaling
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060740
name: prostate gland epithelium morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of epithelia of the prostate gland are generated and organized. Morphogenesis pertains to the creation of form. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0060512 ! prostate gland morphogenesis

[Term]
id: GO:0060741
name: prostate gland stromal morphogenesis
namespace: biological_process
def: "The process by which the prostate gland stroma is generated and organized. Morphogenesis pertains to the creation of form. The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland." [GOC:dph]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060512 ! prostate gland morphogenesis

[Term]
id: GO:0060742
name: epithelial cell differentiation involved in prostate gland development
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland." [GOC:dph]
is_a: GO:0030855 ! epithelial cell differentiation
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060743
name: epithelial cell maturation involved in prostate gland development
namespace: biological_process
def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]
synonym: "prostate gland epithelial cell development" EXACT [GOC:dph]
is_a: GO:0002070 ! epithelial cell maturation
relationship: part_of GO:0060742 ! epithelial cell differentiation involved in prostate gland development

[Term]
id: GO:0060744
name: mammary gland branching involved in thelarche
namespace: biological_process
def: "The process by which the branching structure of the mammary gland duct is generated and organized during the period of sexual maturity in mammals. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, PMID:19261859]
synonym: "mammary gland branching involved in puberty" RELATED [GOC:dph]
is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis
relationship: part_of GO:0042695 ! thelarche

[Term]
id: GO:0060745
name: mammary gland branching involved in pregnancy
namespace: biological_process
def: "The process by which the branching structure of the mammary gland duct is generated and organized as a part of pregnancy." [GOC:dph, PMID:19261859]
is_a: GO:0060135 ! maternal process involved in female pregnancy
is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis

[Term]
id: GO:0060746
name: parental behavior
namespace: biological_process
def: "A reproductive behavior in which a parent cares for and rears offspring." [GOC:dph]
is_a: GO:0033057 ! reproductive behavior in a multicellular organism

[Term]
id: GO:0060747
name: oral incubation
namespace: biological_process
def: "A parental behavior in which fertilized eggs are taken into the mouth and held until hatching." [GOC:dph]
is_a: GO:0060746 ! parental behavior

[Term]
id: GO:0060748
name: tertiary branching involved in mammary gland duct morphogenesis
namespace: biological_process
def: "The branching process by which the mammary gland ducts form tertiary branches off of the secondary branches as part of diestrus and pregnancy." [GOC:dph, PMID:18614704]
is_a: GO:0048754 ! branching morphogenesis of a tube
relationship: part_of GO:0060745 ! mammary gland branching involved in pregnancy

[Term]
id: GO:0060749
name: mammary gland alveolus development
namespace: biological_process
def: "The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0060750
name: epithelial cell proliferation involved in mammary gland duct elongation
namespace: biological_process
def: "The multiplication or reproduction of mammary gland branch epithelial cells, resulting in the elongation of the branch. The mammary gland branch differs from the bud in that it is not the initial curved portion of the outgrowth." [GOC:dph]
is_a: GO:0033598 ! mammary gland epithelial cell proliferation
relationship: part_of GO:0060751 ! mammary gland duct branch elongation

[Term]
id: GO:0060751
name: mammary gland duct branch elongation
namespace: biological_process
def: "The developmental growth process by which a duct in the mammary gland elongates." [GOC:dph]
is_a: GO:0060602 ! branch elongation of an epithelium
relationship: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis

[Term]
id: GO:0060752
name: intestinal phytosterol absorption
namespace: biological_process
def: "Any process by which phytosterols are taken up from the contents of the intestine." [GOC:dph, GOC:tb]
is_a: GO:0015918 ! sterol transport
is_a: GO:0050892 ! intestinal absorption

[Term]
id: GO:0060753
name: regulation of mast cell chemotaxis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
relationship: regulates GO:0002551 ! mast cell chemotaxis

[Term]
id: GO:0060754
name: positive regulation of mast cell chemotaxis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0060753 ! regulation of mast cell chemotaxis
relationship: positively_regulates GO:0002551 ! mast cell chemotaxis

[Term]
id: GO:0060755
name: negative regulation of mast cell chemotaxis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0060753 ! regulation of mast cell chemotaxis
relationship: negatively_regulates GO:0002551 ! mast cell chemotaxis

[Term]
id: GO:0060756
name: foraging behavior
namespace: biological_process
def: "Behavior by which an organism locates food." [GOC:dph, GOC:tb]
is_a: GO:0007610 ! behavior

[Term]
id: GO:0060757
name: adult foraging behavior
namespace: biological_process
def: "Behavior by which an adult locates food." [GOC:dph, GOC:tb]
is_a: GO:0060756 ! foraging behavior

[Term]
id: GO:0060758
name: foraging behavior by probing substrate
namespace: biological_process
def: "Foraging behavior in which an anatomical part of the organism is inserted into the substrate to locate food." [GOC:dph, GOC:tb]
is_a: GO:0060756 ! foraging behavior

[Term]
id: GO:0060759
name: regulation of response to cytokine stimulus
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0034097 ! response to cytokine stimulus

[Term]
id: GO:0060760
name: positive regulation of response to cytokine stimulus
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0060759 ! regulation of response to cytokine stimulus
relationship: positively_regulates GO:0034097 ! response to cytokine stimulus

[Term]
id: GO:0060761
name: negative regulation of response to cytokine stimulus
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0060759 ! regulation of response to cytokine stimulus
relationship: negatively_regulates GO:0034097 ! response to cytokine stimulus

[Term]
id: GO:0060762
name: regulation of branching involved in mammary gland duct morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of branching involved in mammary gland duct morphogenesis." [GOC:dph]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
relationship: regulates GO:0060444 ! branching involved in mammary gland duct morphogenesis

[Term]
id: GO:0060763
name: mammary duct terminal end bud growth
namespace: biological_process
def: "The morphogenetic growth of the large, club-shaped terminal end of a mammary gland duct during prepubertal growth and during puberty." [GOC:dph, PMID:10804170]
is_a: GO:0060560 ! developmental growth involved in morphogenesis
relationship: part_of GO:0060603 ! mammary gland duct morphogenesis

[Term]
id: GO:0060764
name: cell-cell signaling involved in mammary gland development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure." [GOC:dph]
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0030879 ! mammary gland development

[Term]
id: GO:0060765
name: regulation of androgen receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway." [GOC:dph]
is_a: GO:0033143 ! regulation of steroid hormone receptor signaling pathway
relationship: regulates GO:0030521 ! androgen receptor signaling pathway

[Term]
id: GO:0060766
name: negative regulation of androgen receptor signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway." [GOC:dph]
is_a: GO:0033144 ! negative regulation of steroid hormone receptor signaling pathway
is_a: GO:0060765 ! regulation of androgen receptor signaling pathway
relationship: negatively_regulates GO:0030521 ! androgen receptor signaling pathway

[Term]
id: GO:0060767
name: epithelial cell proliferation involved in prostate gland development
namespace: biological_process
def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph]
is_a: GO:0050673 ! epithelial cell proliferation
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060768
name: regulation of epithelial cell proliferation involved in prostate gland development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph]
is_a: GO:0050678 ! regulation of epithelial cell proliferation
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development

[Term]
id: GO:0060769
name: positive regulation of epithelial cell proliferation involved in prostate gland development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph]
is_a: GO:0050679 ! positive regulation of epithelial cell proliferation
is_a: GO:0060768 ! regulation of epithelial cell proliferation involved in prostate gland development
relationship: positively_regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development

[Term]
id: GO:0060770
name: negative regulation of epithelial cell proliferation involved in prostate gland development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph]
is_a: GO:0050680 ! negative regulation of epithelial cell proliferation
is_a: GO:0060768 ! regulation of epithelial cell proliferation involved in prostate gland development
relationship: negatively_regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development

[Term]
id: GO:0060771
name: phyllotactic patterning
namespace: biological_process
def: "The radial pattern formation process that results in the formation of leaf or flower primordia around the center of a shoot apical meristem." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009956 ! radial pattern formation

[Term]
id: GO:0060772
name: leaf phyllotactic patterning
namespace: biological_process
def: "The radial pattern formation process that results in the formation of leaf primordia around the center of a shoot apical meristem." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060771 ! phyllotactic patterning

[Term]
id: GO:0060773
name: flower phyllotactic patterning
namespace: biological_process
def: "The radial pattern formation process that results in the formation of flower primordia around the center of a shoot apical meristem." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060771 ! phyllotactic patterning

[Term]
id: GO:0060774
name: auxin mediated signaling pathway involved in phyllotactic patterning
namespace: biological_process
def: "The series of molecular signals generated in response to detection of auxin that contributes to the radial pattern formation process resulting in the formation of leaf or flower primordia around the center of a shoot apical meristem." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009734 ! auxin mediated signaling pathway
relationship: part_of GO:0060771 ! phyllotactic patterning

[Term]
id: GO:0060775
name: planar cell polarity pathway involved in gastrula mediolateral intercalation
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) contributing to the interdigitation of cells along the mediolateral axis during gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway
relationship: part_of GO:0060031 ! mediolateral intercalation

[Term]
id: GO:0060776
name: simple leaf morphogenesis
namespace: biological_process
def: "The leaf morphogenesis process which results in the shaping of a simple leaf. A simple leaf is a leaf in which the lamina is undivided." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009965 ! leaf morphogenesis

[Term]
id: GO:0060777
name: compound leaf morphogenesis
namespace: biological_process
def: "The leaf morphogenesis process that results in the shaping of a compound leaf. A compound leaf is a leaf having two or more distinct leaflets that are evident as such from early in development." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009965 ! leaf morphogenesis

[Term]
id: GO:0060778
name: primary leaflet morphogenesis
namespace: biological_process
def: "The process by which the primary leaflet attains its shape. A primary leaflet is a leaflet that develops directly from the rachis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060794 ! leaflet morphogenesis

[Term]
id: GO:0060779
name: secondary leaflet morphogenesis
namespace: biological_process
def: "The process by which the secondary leaflet attains its shape. A secondary leaflet develops by branching or division of a primary leaflet." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060794 ! leaflet morphogenesis

[Term]
id: GO:0060780
name: intercalary leaflet morphogenesis
namespace: biological_process
def: "The process by which the intercalary leaflet attains its shape. An intercalary leaflet is a leaflet that develops between primary leaflets." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060794 ! leaflet morphogenesis

[Term]
id: GO:0060781
name: mesenchymal cell proliferation involved in prostate gland development
namespace: biological_process
def: "The multiplication or reproduction of mesenchymal cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph, PMID:12221011]
is_a: GO:0010463 ! mesenchymal cell proliferation
relationship: part_of GO:0030850 ! prostate gland development

[Term]
id: GO:0060782
name: regulation of mesenchymal cell proliferation involved in prostate gland development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the prostate gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, PMID:12221011]
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0060781 ! mesenchymal cell proliferation involved in prostate gland development

[Term]
id: GO:0060783
name: mesenchymal smoothened signaling pathway involved in prostate gland development
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein in the mesenchymal cells of the prostate that contribute to the progression of the prostate over time. This process contributes to lung development." [PMID:12221011]
is_a: GO:0007224 ! smoothened signaling pathway
relationship: part_of GO:0060738 ! epithelial-mesenchymal signaling involved in prostate gland development

[Term]
id: GO:0060784
name: regulation of cell proliferation involved in tissue homeostasis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the equilibrium of the number of cell within a tissue." [GOC:dph]
is_a: GO:0042127 ! regulation of cell proliferation
relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue

[Term]
id: GO:0060785
name: regulation of apoptosis involved in tissue homeostasis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the equilibrium of the number of cells within a tissue." [GOC:dph]
is_a: GO:0042981 ! regulation of apoptosis
relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue

[Term]
id: GO:0060786
name: regulation of cell differentiation involved in tissue homeostasis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of an equilibrium of a cell type within a tissue." [GOC:dph]
is_a: GO:0045595 ! regulation of cell differentiation
relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue

[Term]
id: GO:0060787
name: positive regulation of posterior neural plate formation by fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "Any process that increases the rate or extent of the formation of the posterior neural plate, the posterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "positive regulation of posterior neural plate formation by FGF receptor signaling pathway" RELATED [GOC:dph, GOC:tb]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0090018 ! posterior neural plate formation

[Term]
id: GO:0060788
name: ectodermal placode formation
namespace: biological_process
def: "The developmental process by which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0060789
name: hair follicle placode formation
namespace: biological_process
def: "The developmental process by which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0001942 ! hair follicle development

[Term]
id: GO:0060790
name: tooth placode formation
namespace: biological_process
def: "The developmental process by which the tooth placode forms. An tooth placode is a thickening of the ectoderm that will give rise to the tooth bud." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0042475 ! odontogenesis of dentine-containing tooth

[Term]
id: GO:0060791
name: sebaceous gland placode formation
namespace: biological_process
def: "The developmental process by which a sebaceous gland placode forms. A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0048733 ! sebaceous gland development

[Term]
id: GO:0060792
name: sweat gland development
namespace: biological_process
def: "The progression of the sweat gland over time, from its formation to the mature structure. Sweat glands secrete an aqueous solution that is used in thermoregulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048732 ! gland development

[Term]
id: GO:0060793
name: sweat gland placode formation
namespace: biological_process
def: "The developmental process by which the sweat gland placode forms. An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060788 ! ectodermal placode formation
relationship: part_of GO:0060792 ! sweat gland development

[Term]
id: GO:0060794
name: leaflet morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the leaflet are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060777 ! compound leaf morphogenesis

[Term]
id: GO:0060795
name: cell fate commitment involved in the formation of primary germ layers
namespace: biological_process
def: "The commitment of cells to specific cell fates of the endoderm, ectoderm and mesoderm as a part of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0001704 ! formation of primary germ layer

[Term]
id: GO:0060796
name: regulation of transcription involved in primary germ layer cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in cells adopting an endoderm, ectoderm or mesoderm cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment
relationship: part_of GO:0060795 ! cell fate commitment involved in the formation of primary germ layers

[Term]
id: GO:0060797
name: transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt a mesoderm fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway
relationship: part_of GO:0060795 ! cell fate commitment involved in the formation of primary germ layers

[Term]
id: GO:0060798
name: transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of a mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060797 ! transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment
relationship: part_of GO:0007501 ! mesodermal cell fate specification

[Term]
id: GO:0060799
name: transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt an endoderm fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060797 ! transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment
relationship: part_of GO:0001714 ! endodermal cell fate specification

[Term]
id: GO:0060800
name: regulation of cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0045995 ! regulation of embryonic development
relationship: regulates GO:0060706 ! cell differentiation involved in embryonic placenta development

[Term]
id: GO:0060801
name: negative regulation of trophoblast cell differentiation by transforming growth factor beta signaling pathway
namespace: biological_process
def: "The transforming growth factor signaling process that decreases the rate, frequency, or extent of trophoblast stem cells differentiating into the more mature cells of the trophoblast." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060806 ! negative regulation of cell differentiation involved in embryonic placenta development

[Term]
id: GO:0060802
name: epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification
namespace: biological_process
def: "Any process that mediates the transfer of information from an epiblast cell to an extraembryonic ectoderm cell that contributes to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0009948 ! anterior/posterior axis specification

[Term]
id: GO:0060803
name: BMP signaling pathway involved in mesodermal cell fate specification
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor and ultimately resulting in an cell becoming specified to adopt a mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0030509 ! BMP signaling pathway
relationship: part_of GO:0007501 ! mesodermal cell fate specification

[Term]
id: GO:0060804
name: positive regulation of WNT receptor signaling pathway by BMP signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in an increase in the rate, frequency or extent of a WNT receptor signaling pathway." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0030177 ! positive regulation of Wnt receptor signaling pathway
is_a: GO:0030509 ! BMP signaling pathway

[Term]
id: GO:0060805
name: negative regulation of trophoblast cell differentiation by transcription regulation from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of transcription from an RNA polymerase II promoter ultimately resulting in a decrease in trophoblast stem cells differentiating into the more mature cells of the trophoblast." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060806 ! negative regulation of cell differentiation involved in embryonic placenta development

[Term]
id: GO:0060806
name: negative regulation of cell differentiation involved in embryonic placenta development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0060800 ! regulation of cell differentiation involved in embryonic placenta development
relationship: negatively_regulates GO:0060706 ! cell differentiation involved in embryonic placenta development

[Term]
id: GO:0060807
name: regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that ultimately results in a cell being specified to adopt a definitive endodermal cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0001714 ! endodermal cell fate specification

[Term]
id: GO:0060808
name: positive regulation of mesodermal to mesenchymal transition involved in gastrulation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition
relationship: positively_regulates GO:0060809 ! mesodermal to mesenchymal transition involved in gastrulation

[Term]
id: GO:0060809
name: mesodermal to mesenchymal transition involved in gastrulation
namespace: biological_process
def: "The epithelial to mesenchymal transition process in which a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001837 ! epithelial to mesenchymal transition
relationship: part_of GO:0007369 ! gastrulation

[Term]
id: GO:0060810
name: intracellular mRNA localization involved in pattern specification process
namespace: biological_process
def: "Any process by which mRNA is transported to, or maintained in, a specific location within an oocyte that results in a pattern being established in the embryo." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0008298 ! intracellular mRNA localization
relationship: part_of GO:0007389 ! pattern specification process

[Term]
id: GO:0060811
name: intracellular mRNA localization involved in anterior/posterior axis specification
namespace: biological_process
def: "Any process by which mRNA is transported to, or maintained in, a specific location within the oocyte and/or syncytial embryo that contributes to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060810 ! intracellular mRNA localization involved in pattern specification process
relationship: part_of GO:0009948 ! anterior/posterior axis specification

[Term]
id: GO:0060812
name: orthodenticle mRNA localization
namespace: biological_process
def: "Any process by which orthodenticle mRNA is transported to and maintained in the oocyte and/or syncytial embryo as part of the process that will specify the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification

[Term]
id: GO:0060813
name: anterior mRNA localization involved in anterior/posterior axis specification
namespace: biological_process
def: "Any process by which a mRNA is transported to, and maintained in the anterior portion of the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification

[Term]
id: GO:0060814
name: posterior mRNA localization involved in anterior/posterior axis specification
namespace: biological_process
def: "Any process by which a mRNA is transported to and maintained in the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification

[Term]
id: GO:0060815
name: regulation of translation involved in anterior/posterior axis specification
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation of mRNAs that contribute to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0006417 ! regulation of translation
relationship: part_of GO:0009948 ! anterior/posterior axis specification

[Term]
id: GO:0060816
name: random inactivation of X chromosome
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009048 ! dosage compensation, by inactivation of X chromosome

[Term]
id: GO:0060817
name: inactivation of paternal X chromosome
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes specifically on the paternal X-chromosome in the XX sex." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009048 ! dosage compensation, by inactivation of X chromosome

[Term]
id: GO:0060818
name: inactivation of paternal X chromosome by genetic imprinting
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on the paternal X-chromosome in the XX sex by genetic imprinting." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060817 ! inactivation of paternal X chromosome
is_a: GO:0060819 ! inactivation of X chromosome by genetic imprinting

[Term]
id: GO:0060819
name: inactivation of X chromosome by genetic imprinting
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by genetic imprinting." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0006349 ! regulation of gene expression by genetic imprinting
is_a: GO:0009048 ! dosage compensation, by inactivation of X chromosome

[Term]
id: GO:0060820
name: inactivation of X chromosome by heterochromatin formation
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by the mechanism of heterochromatin formation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009048 ! dosage compensation, by inactivation of X chromosome
is_a: GO:0031507 ! heterochromatin formation

[Term]
id: GO:0060821
name: inactivation of X chromosome by DNA methylation
namespace: biological_process
def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by a mechanism of DNA methylation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009048 ! dosage compensation, by inactivation of X chromosome

[Term]
id: GO:0060822
name: transforming growth factor beta receptor signaling pathway involved in axial mesodermal cell fate specification
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of an axial mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060798 ! transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification
relationship: part_of GO:0048327 ! axial mesodermal cell fate specification

[Term]
id: GO:0060823
name: Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes that contributes to the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060070 ! Wnt receptor signaling pathway through beta-catenin
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization

[Term]
id: GO:0060824
name: retinoic acid receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to the formation of the anterior/posterior pattern of the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048384 ! retinoic acid receptor signaling pathway
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization

[Term]
id: GO:0060825
name: fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the anterior/posterior pattern of the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization

[Term]
id: GO:0060826
name: transforming growth factor beta receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands, contributing to the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway
relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization

[Term]
id: GO:0060827
name: regulation of Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of Wnt receptor signaling through beta-catenin that results in the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0060828 ! regulation of Wnt receptor signaling pathway through beta-catenin
relationship: regulates GO:0060823 ! Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation

[Term]
id: GO:0060828
name: regulation of Wnt receptor signaling pathway through beta-catenin
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the Wnt receptor signaling pathway through beta-catenin, the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway
relationship: regulates GO:0060070 ! Wnt receptor signaling pathway through beta-catenin

[Term]
id: GO:0060829
name: negative regulation of Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the Wnt receptor signaling pathway through beta-catenin in the anterior end of the neural plate. This regulation sets up a Wnt signaling gradient along the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0030178 ! negative regulation of Wnt receptor signaling pathway
is_a: GO:0060827 ! regulation of Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation

[Term]
id: GO:0060830
name: ciliary receptor clustering involved in smoothened signaling pathway
namespace: biological_process
def: "Grouping of smoothened or patched receptors in a cilium, contributing to the smoothened signaling pathway." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0043113 ! receptor clustering
relationship: part_of GO:0007224 ! smoothened signaling pathway

[Term]
id: GO:0060831
name: smoothened signaling pathway involved in dorsal/ventral neural tube patterning
namespace: biological_process
def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the dorsal/ventral pattern of the neural tube." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007224 ! smoothened signaling pathway
relationship: part_of GO:0021904 ! dorsal/ventral neural tube patterning

[Term]
id: GO:0060832
name: oocyte animal/vegetal axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the animal/vegetal axis in the oocyte. The animal/vegetal axis of an oocyte is defined by the placement of the nucleus in the oocyte and can sometimes be identified by the asymmetric placement of other substances such as yolk in the oocyte. The pole of the egg that is closest to the nucleus defines the animal end, with the axis passing through the nucleus." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007309 ! oocyte axis specification

[Term]
id: GO:0060833
name: Wnt receptor signaling pathway involved in animal/vegetal axis specification
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the specification of the animal/vegetal axis of an oocyte." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0016055 ! Wnt receptor signaling pathway
relationship: part_of GO:0060832 ! oocyte animal/vegetal axis specification

[Term]
id: GO:0060834
name: oral/aboral axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of a line that delineates the mouth and the anus of an embryo." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "oral/aboral axis determination" RELATED [GOC:dph]
is_a: GO:0000578 ! embryonic axis specification

[Term]
id: GO:0060835
name: transforming growth factor receptor beta signaling pathway involved in oral/aboral axis specification
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to the specification of the oral/aboral axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway
relationship: part_of GO:0060834 ! oral/aboral axis specification

[Term]
id: GO:0060836
name: lymphatic endothelial cell differentiation
namespace: biological_process
def: "The process whereby a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045446 ! endothelial cell differentiation
relationship: part_of GO:0001945 ! lymph vessel development

[Term]
id: GO:0060837
name: blood vessel endothelial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045446 ! endothelial cell differentiation
relationship: part_of GO:0001568 ! blood vessel development

[Term]
id: GO:0060838
name: lymphatic endothelial cell fate commitment
namespace: biological_process
def: "The commitment of a venous blood vessel endothelial cell to a lymphatic endothelial cell fate and its capacity to differentiate into a lymphatic endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060839 ! endothelial cell fate commitment
relationship: part_of GO:0060836 ! lymphatic endothelial cell differentiation

[Term]
id: GO:0060839
name: endothelial cell fate commitment
namespace: biological_process
def: "The commitment of a cell to an endothelial cell fate and its capacity to differentiate into an endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0045446 ! endothelial cell differentiation

[Term]
id: GO:0060840
name: artery development
namespace: biological_process
def: "The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001568 ! blood vessel development

[Term]
id: GO:0060841
name: venous blood vessel development
namespace: biological_process
def: "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001568 ! blood vessel development

[Term]
id: GO:0060842
name: arterial endothelial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060837 ! blood vessel endothelial cell differentiation

[Term]
id: GO:0060843
name: venous endothelial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060837 ! blood vessel endothelial cell differentiation

[Term]
id: GO:0060844
name: arterial endothelial cell fate commitment
namespace: biological_process
def: "The commitment of a cell to an arterial endothelial cell fate and its capacity to differentiate into an arterial endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060846 ! blood vessel endothelial cell fate commitment
relationship: part_of GO:0060842 ! arterial endothelial cell differentiation

[Term]
id: GO:0060845
name: venous endothelial cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a venous endothelial cell fate and its capacity to differentiate into an venous endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060846 ! blood vessel endothelial cell fate commitment
relationship: part_of GO:0060843 ! venous endothelial cell differentiation

[Term]
id: GO:0060846
name: blood vessel endothelial cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a blood vessel endothelial cell fate and its capacity to differentiate into a blood vessel endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060839 ! endothelial cell fate commitment
relationship: part_of GO:0060837 ! blood vessel endothelial cell differentiation

[Term]
id: GO:0060847
name: endothelial cell fate specification
namespace: biological_process
def: "The process involved in the specification of identity of an endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0060839 ! endothelial cell fate commitment

[Term]
id: GO:0060848
name: endothelial cell fate determination
namespace: biological_process
def: "Process involved in cell fate commitment of an endothelial cell. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0060839 ! endothelial cell fate commitment

[Term]
id: GO:0060849
name: regulation of transcription involved in lymphatic endothelial cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment
relationship: part_of GO:0060838 ! lymphatic endothelial cell fate commitment

[Term]
id: GO:0060850
name: regulation of transcription involved in cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter

[Term]
id: GO:0060851
name: vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
namespace: biological_process
def: "The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway
relationship: part_of GO:0060838 ! lymphatic endothelial cell fate commitment

[Term]
id: GO:0060852
name: regulation of transcription involved in venous endothelial cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate and contributes to a cell adopting a venous endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060845 ! venous endothelial cell fate commitment
is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment

[Term]
id: GO:0060853
name: Notch signaling pathway involved in arterial endothelial cell fate commitment
namespace: biological_process
def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the commitment of a cell to an arterial endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007219 ! Notch signaling pathway
relationship: part_of GO:0060844 ! arterial endothelial cell fate commitment

[Term]
id: GO:0060854
name: patterning of lymph vessels
namespace: biological_process
def: "The process that regulates the coordinated growth and sprouting of lymph vessels giving rise to the organized lymphatic system." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0001946 ! lymphangiogenesis

[Term]
id: GO:0060855
name: venous endothelial cell migration involved in lymph vessel development
namespace: biological_process
def: "The orderly movement of venous endothelial cells out of the veins giving rise to the precursors of lymphatic endothelial cells." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0043534 ! blood vessel endothelial cell migration
relationship: part_of GO:0001945 ! lymph vessel development

[Term]
id: GO:0060856
name: establishment of blood-brain barrier
namespace: biological_process
def: "Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
is_a: GO:0048468 ! cell development

[Term]
id: GO:0060857
name: establishment of glial blood-brain barrier
namespace: biological_process
def: "Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart]
is_a: GO:0021782 ! glial cell development
is_a: GO:0060856 ! establishment of blood-brain barrier

[Term]
id: GO:0060858
name: vesicle-mediated transport involved in floral organ abscission
namespace: biological_process
def: "The directed movement of substances within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane which are then targeted to, and fuse with, an acceptor membrane contributing to the shedding of a floral organ." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "membrane trafficking involved in floral organ shedding" RELATED [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0016192 ! vesicle-mediated transport
relationship: part_of GO:0010227 ! floral organ abscission

[Term]
id: GO:0060859
name: regulation of vesicle-mediated transport involved in floral organ abscission
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the directed movement of substances within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane which are then targeted to, and fuse with, an acceptor membrane contributing to the shedding of a floral organ." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060627 ! regulation of vesicle-mediated transport
is_a: GO:0060860 ! regulation of floral organ abscission
relationship: regulates GO:0060858 ! vesicle-mediated transport involved in floral organ abscission

[Term]
id: GO:0060860
name: regulation of floral organ abscission
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009909 ! regulation of flower development
relationship: regulates GO:0010227 ! floral organ abscission

[Term]
id: GO:0060861
name: positive regulation of floral organ abscission
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of floral organ shedding, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0060860 ! regulation of floral organ abscission
relationship: positively_regulates GO:0010227 ! floral organ abscission

[Term]
id: GO:0060862
name: negative regulation of floral organ abscission
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0060860 ! regulation of floral organ abscission
relationship: negatively_regulates GO:0010227 ! floral organ abscission

[Term]
id: GO:0060863
name: regulation of floral organ abscission by signal transduction
namespace: biological_process
def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately modulating the rate, or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007165 ! signal transduction
is_a: GO:0060860 ! regulation of floral organ abscission

[Term]
id: GO:0060864
name: positive regulation of floral organ abscission by small GTPase mediated signal transduction
namespace: biological_process
def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals that increases the rate or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007264 ! small GTPase mediated signal transduction
is_a: GO:0060861 ! positive regulation of floral organ abscission
is_a: GO:0060863 ! regulation of floral organ abscission by signal transduction

[Term]
id: GO:0060865
name: negative regulation of floral organ abscission by transmembrane receptor protein serine/threonine kinase signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand and contributing to the decrease in the rate or frequency of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway
is_a: GO:0060862 ! negative regulation of floral organ abscission

[Term]
id: GO:0060866
name: leaf abscission
namespace: biological_process
def: "The controlled shedding of a leaf." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009838 ! abscission

[Term]
id: GO:0060867
name: fruit abscission
namespace: biological_process
def: "The controlled shedding of a fruit." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009838 ! abscission

[Term]
id: GO:0060868
name: regulation of vesicle-mediated transport involved in floral organ abscission by small GTPase mediated signal transduction
namespace: biological_process
def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals that modulates the rate or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007264 ! small GTPase mediated signal transduction
is_a: GO:0060859 ! regulation of vesicle-mediated transport involved in floral organ abscission

[Term]
id: GO:0060869
name: transmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand that contributes to the process of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: part_of GO:0010227 ! floral organ abscission

[Term]
id: GO:0060870
name: cell wall disassembly involved in floral organ abscission
namespace: biological_process
def: "A cellular process that results in the breakdown of the cell wall that contributes to the process of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009830 ! cell wall modification during abscission
relationship: part_of GO:0010227 ! floral organ abscission

[Term]
id: GO:0060871
name: cellular cell wall disassembly
namespace: biological_process
def: "A cellular process that results in the breakdown of the cell wall." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007047 ! cellular cell wall organization
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0044277 ! cell wall disassembly

[Term]
id: GO:0060872
name: semicircular canal development
namespace: biological_process
def: "The progression of the semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048839 ! inner ear development

[Term]
id: GO:0060873
name: anterior semicircular canal development
namespace: biological_process
def: "The progession of the anterior semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060872 ! semicircular canal development

[Term]
id: GO:0060874
name: posterior semicircular canal development
namespace: biological_process
def: "The progession of the posterior semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060872 ! semicircular canal development

[Term]
id: GO:0060875
name: lateral semicircular canal development
namespace: biological_process
def: "The progession of the lateral semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060872 ! semicircular canal development

[Term]
id: GO:0060876
name: semicircular canal formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the semicircular canal from the otic vesicle. This process begins with the regionalization of the vesicle that specifies the area where the vesicles will form and continues through the process of fusion which forms the initial tubes." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048752 ! semicircular canal morphogenesis

[Term]
id: GO:0060877
name: regionalization involved in semicircular canal formation
namespace: biological_process
def: "The pattern specification process by which the otic epithelium is subdivided in space to define an area or volume in which cells will differentiate to give rise to the semicircular canals." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0060876 ! semicircular canal formation

[Term]
id: GO:0060878
name: pouch outgrowth involved in semicircular canal formation
namespace: biological_process
def: "The morphogenetic process by which an epithelial sheet bends along a linear axis and gives rise to a pouch that will form a semicircular canal." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060571 ! morphogenesis of an epithelial fold
relationship: part_of GO:0060876 ! semicircular canal formation

[Term]
id: GO:0060879
name: semicircular canal fusion
namespace: biological_process
def: "Creation of the central hole of the semicircular canal by sealing the edges of the pouch that forms ruing the process of semicircular canal formation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060606 ! tube closure
relationship: part_of GO:0060876 ! semicircular canal formation

[Term]
id: GO:0060880
name: cell morphogenesis involved in semicircular canal fusion
namespace: biological_process
def: "The change in form (cell shape and size) that occurs when a semicircular canal epithelial cell acquires the structural features that allow it to contribute to the process of semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0060879 ! semicircular canal fusion

[Term]
id: GO:0060881
name: basal lamina disassembly
namespace: biological_process
def: "A process that results in the breakdown of the basal lamina." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0022617 ! extracellular matrix disassembly

[Term]
id: GO:0060882
name: basal lamina disassembly involved in semicircular canal fusion
namespace: biological_process
def: "A process that results in the breakdown of the basal lamina that contributes to the process of semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060881 ! basal lamina disassembly
relationship: part_of GO:0060876 ! semicircular canal formation

[Term]
id: GO:0060883
name: regulation of basal lamina disassembly involved in semicircular canal fusion by cell communication
namespace: biological_process
def: "Any process that mediates interactions between a cell and its surroundings that modulates of the rate, frequency or extent of basal lamina disassembly involved in semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007154 ! cell communication
is_a: GO:0010715 ! regulation of extracellular matrix disassembly
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045995 ! regulation of embryonic development
relationship: regulates GO:0060882 ! basal lamina disassembly involved in semicircular canal fusion

[Term]
id: GO:0060884
name: clearance of cells from fusion plate
namespace: biological_process
def: "The morphogenetic process by which cells are removed from the inner loop of a semicircular canal." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0048752 ! semicircular canal morphogenesis

[Term]
id: GO:0060885
name: clearance of cells from fusion plate by apoptosis
namespace: biological_process
def: "The process of apoptosis that contributes to the shaping of the semicircular canal by removing cells in the fusion plate, forming the loops of the canals." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060561 ! apoptosis involved in morphogenesis
is_a: GO:0060884 ! clearance of cells from fusion plate

[Term]
id: GO:0060886
name: clearance of cells from fusion plate by epithelial to mesenchymal transition
namespace: biological_process
def: "The process of epithelial to mesenchymal transition that contributes to the shaping of the semicircular canal by effectively removing epithelial cells from the fusion plate, forming the loops of the canals." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0001837 ! epithelial to mesenchymal transition
is_a: GO:0060884 ! clearance of cells from fusion plate

[Term]
id: GO:0060887
name: limb epidermis development
namespace: biological_process
def: "The process whose specific outcome is the progression of the epidermis of the limb over time, from its formation to the mature structure. The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0008544 ! epidermis development
relationship: part_of GO:0060173 ! limb development

[Term]
id: GO:0060888
name: limb epidermis stratification
namespace: biological_process
def: "The pattern specification process by which the epidermis of the limb is subdivided in space to define a volume in which specific patterns of basal cell, spinous cell and granular cells will differentiate giving rise to the layers of the limb epidermis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0003002 ! regionalization
is_a: GO:0060887 ! limb epidermis development

[Term]
id: GO:0060889
name: limb basal epidermal cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a limb epidermal basal cell. A epidermal basal cell cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into more specialized cell of the limb epidermis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009913 ! epidermal cell differentiation
is_a: GO:0048863 ! stem cell differentiation
relationship: part_of GO:0060887 ! limb epidermis development

[Term]
id: GO:0060890
name: limb spinous cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a limb epidermal spinous cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0030216 ! keratinocyte differentiation
relationship: part_of GO:0060887 ! limb epidermis development

[Term]
id: GO:0060891
name: limb granular cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a limb epidermal granular cell." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0030216 ! keratinocyte differentiation
relationship: part_of GO:0060887 ! limb epidermis development

[Term]
id: GO:0060892
name: limb basal epidermal cell fate specification
namespace: biological_process
def: "The process by which a cell becomes capable of differentiating autonomously into an limb basal epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009957 ! epidermal cell fate specification
relationship: part_of GO:0060888 ! limb epidermis stratification
relationship: part_of GO:0060889 ! limb basal epidermal cell differentiation

[Term]
id: GO:0060893
name: limb granular cell fate specification
namespace: biological_process
def: "The process by which a cell becomes capable of differentiating autonomously into an limb granular cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009957 ! epidermal cell fate specification
relationship: part_of GO:0060888 ! limb epidermis stratification
relationship: part_of GO:0060891 ! limb granular cell differentiation

[Term]
id: GO:0060894
name: limb spinous cell fate specification
namespace: biological_process
def: "The process by which a cell becomes capable of differentiating autonomously into a limb spinous cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009957 ! epidermal cell fate specification
relationship: part_of GO:0060888 ! limb epidermis stratification
relationship: part_of GO:0060890 ! limb spinous cell differentiation

[Term]
id: GO:0060895
name: retinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to the dorsal ventral patterning of the spinal cord." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048384 ! retinoic acid receptor signaling pathway
relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning

[Term]
id: GO:0060896
name: neural plate pattern specification
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007389 ! pattern specification process

[Term]
id: GO:0060897
name: neural plate regionalization
namespace: biological_process
def: "The pattern specification process by which an axis or axes of the neural plate is subdivided in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0060896 ! neural plate pattern specification

[Term]
id: GO:0060898
name: camera-type eye field cell fate commitment
namespace: biological_process
def: "The commitment of neurectodermal cells to cells of the eye field and their capacity to differentiate into eye field cells. Eye field cells are neurectodermal cells that will form the optic placode." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0046619 ! optic placode formation involved in camera-type eye
relationship: part_of GO:0060897 ! neural plate regionalization

[Term]
id: GO:0060899
name: regulation of transcription involved in camera-type eye field cell fate commitment
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neurectodermal cell to a specialized neurectodermal cell that will give rise to the optic vesicle." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment
relationship: part_of GO:0060898 ! camera-type eye field cell fate commitment

[Term]
id: GO:0060900
name: embryonic camera-type eye formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis

[Term]
id: GO:0060901
name: regulation of hair cycle by Wnt receptor signaling pathway through beta-catenin
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes that modulates the rate, frequency or extent of the hair cycle." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0042634 ! regulation of hair cycle
is_a: GO:0060070 ! Wnt receptor signaling pathway through beta-catenin

[Term]
id: GO:0060902
name: regulation of hair cycle by BMP signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that modulates the rate, frequency or extent of the hair cycle." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0030509 ! BMP signaling pathway
is_a: GO:0042634 ! regulation of hair cycle

[Term]
id: GO:0060903
name: positive regulation of meiosis I
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:tb]
is_a: GO:0060631 ! regulation of meiosis I
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0007127 ! meiosis I

[Term]
id: GO:0060904
name: regulation of protein folding in endoplasmic reticulum
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:dph, GOC:tb]
is_a: GO:0032268 ! regulation of cellular protein metabolic process
relationship: regulates GO:0034975 ! protein folding in endoplasmic reticulum

[Term]
id: GO:0060905
name: regulation of induction of conjugation upon nitrogen starvation
namespace: biological_process
def: "Any process that modulates the frequency of induction of conjugation upon nitrogen starvation, the process by which a cell initiates conjugation with cellular fusion upon nitrogen starvation." [GOC:dph, GOC:tb]
is_a: GO:0010646 ! regulation of cell communication
is_a: GO:0032107 ! regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0031142 ! induction of conjugation upon nitrogen starvation

[Term]
id: GO:0060906
name: negative regulation of chromatin silencing by small RNA
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of chromatin silencing by small RNA. Chromatin silencing by small RNA is the repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:tb]
is_a: GO:0010964 ! regulation of chromatin silencing by small RNA
is_a: GO:0031936 ! negative regulation of chromatin silencing
is_a: GO:0060967 ! negative regulation of gene silencing by RNA
relationship: negatively_regulates GO:0031048 ! chromatin silencing by small RNA

[Term]
id: GO:0060907
name: positive regulation of macrophage cytokine production
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:dph, GOC:tb]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0010935 ! regulation of macrophage cytokine production

[Term]
id: GO:0060908
name: plasmid copy number maintenance
namespace: biological_process
def: "The maintenance of the number of copies of extrachromosomal plasmid DNA." [GOC:dph, GOC:tb]
is_a: GO:0006276 ! plasmid maintenance

[Term]
id: GO:0060909
name: regulation of DNA replication initiation involved in plasmid copy number maintenance
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance." [GOC:dph, GOC:tb]
is_a: GO:0030174 ! regulation of DNA replication initiation
relationship: part_of GO:0060908 ! plasmid copy number maintenance

[Term]
id: GO:0060910
name: negative regulation of DNA replication initiation involved in plasmid copy number maintenance
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance." [GOC:dph, GOC:tb]
is_a: GO:0032297 ! negative regulation of DNA replication initiation
is_a: GO:0060909 ! regulation of DNA replication initiation involved in plasmid copy number maintenance

[Term]
id: GO:0060911
name: cardiac cell fate commitment
namespace: biological_process
def: "The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system." [GOC:mtg_heart]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0035051 ! cardiac cell differentiation

[Term]
id: GO:0060912
name: cardiac cell fate specification
namespace: biological_process
def: "The process involved in the specification of cardiac cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:mtg_heart]
is_a: GO:0001708 ! cell fate specification
relationship: part_of GO:0060911 ! cardiac cell fate commitment

[Term]
id: GO:0060913
name: cardiac cell fate determination
namespace: biological_process
def: "Process involved in cardiac cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:mtg_heart]
is_a: GO:0001709 ! cell fate determination
relationship: part_of GO:0060911 ! cardiac cell fate commitment

[Term]
id: GO:0060914
name: heart formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart]
synonym: "cardiogenesis" RELATED [GOC:mtg_heart]
is_a: GO:0048645 ! organ formation
relationship: part_of GO:0003007 ! heart morphogenesis

[Term]
id: GO:0060915
name: mesenchymal cell differentiation involved in lung development
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph]
is_a: GO:0048762 ! mesenchymal cell differentiation
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060916
name: mesenchymal cell proliferation involved in lung development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph]
is_a: GO:0010463 ! mesenchymal cell proliferation
relationship: part_of GO:0030324 ! lung development

[Term]
id: GO:0060917
name: regulation of 1,6-beta-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta-1,6 glucans." [GOC:dph, GOC:tb]
is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process
relationship: regulates GO:0006078 ! 1,6-beta-glucan biosynthetic process

[Term]
id: GO:0060918
name: auxin transport
namespace: biological_process
def: "The directed movement of auxin into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0009914 ! hormone transport

[Term]
id: GO:0060919
name: auxin influx
namespace: biological_process
def: "The process involved in the transport of auxin into the cell." [GOC:dph, GOC:tb]
is_a: GO:0060918 ! auxin transport

[Term]
id: GO:0060920
name: pacemaker cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_heart]
is_a: GO:0055007 ! cardiac muscle cell differentiation

[Term]
id: GO:0060921
name: sinoatrial node cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart]
synonym: "SA node cell differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0060920 ! pacemaker cell differentiation
relationship: part_of GO:0003163 ! sinoatrial node development

[Term]
id: GO:0060922
name: atrioventricular node cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node." [GOC:mtg_heart]
synonym: "AV node cell differentiation" RELATED [GOC:mtg_heart]
is_a: GO:0060920 ! pacemaker cell differentiation
relationship: part_of GO:0003162 ! atrioventricular node development

[Term]
id: GO:0060923
name: cardiac muscle cell fate commitment
namespace: biological_process
def: "The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart]
synonym: "cardiomyocyte cell fate commitment" EXACT [GOC:mtg_heart]
synonym: "heart muscle cell fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0055007 ! cardiac muscle cell differentiation

[Term]
id: GO:0060924
name: atrial cardiac muscle cell fate commitment
namespace: biological_process
def: "The commitment of cells to atrial cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart]
synonym: "atrial cardiomyocyte cell fate commitment" RELATED [GOC:mtg_heart]
synonym: "atrial heart muscle cell fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0060923 ! cardiac muscle cell fate commitment
relationship: part_of GO:0055011 ! atrial cardiac muscle cell differentiation

[Term]
id: GO:0060925
name: ventricular cardiac muscle cell fate commitment
namespace: biological_process
def: "The commitment of cells to ventricular cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the ventricle. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart]
synonym: "ventricular cardiomyocyte cell fate commitment" EXACT [GOC:mtg_heart]
synonym: "ventricular heart muscle cell fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0060923 ! cardiac muscle cell fate commitment
relationship: part_of GO:0055012 ! ventricular cardiac muscle cell differentiation

[Term]
id: GO:0060926
name: pacemaker cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_heart]
is_a: GO:0055013 ! cardiac muscle cell development
relationship: part_of GO:0060920 ! pacemaker cell differentiation

[Term]
id: GO:0060927
name: pacemaker cell fate commitment
namespace: biological_process
def: "The commitment of cells to pacemaker cell fates and their capacity to differentiate into pacemaker cells. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_heart]
is_a: GO:0060923 ! cardiac muscle cell fate commitment
relationship: part_of GO:0060920 ! pacemaker cell differentiation

[Term]
id: GO:0060928
name: atrioventricular node cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state." [GOC:mtg_heart]
synonym: "AV node cell development" EXACT [GOC:mtg_heart]
is_a: GO:0060926 ! pacemaker cell development
relationship: part_of GO:0060922 ! atrioventricular node cell differentiation

[Term]
id: GO:0060929
name: atrioventricular node cell fate commitment
namespace: biological_process
def: "The commitment of cells to atrioventricular (AV) node cell fates and their capacity to differentiate into AV node cells." [GOC:mtg_heart]
synonym: "AV node cell fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0060927 ! pacemaker cell fate commitment
relationship: part_of GO:0060922 ! atrioventricular node cell differentiation

[Term]
id: GO:0060930
name: sinoatrial node cell fate commitment
namespace: biological_process
def: "The commitment of cells to sinoatrial (SA) node cell fates and their capacity to differentiate into SA node cells. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart]
synonym: "SA node cell commitment" EXACT [GOC:mtg_heart]
is_a: GO:0060927 ! pacemaker cell fate commitment
relationship: part_of GO:0060921 ! sinoatrial node cell differentiation

[Term]
id: GO:0060931
name: sinoatrial node cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart]
synonym: "SA node cell development" EXACT [GOC:mtg_heart]
is_a: GO:0060926 ! pacemaker cell development
relationship: part_of GO:0060921 ! sinoatrial node cell differentiation

[Term]
id: GO:0060932
name: His-Purkinje system cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0055007 ! cardiac muscle cell differentiation
relationship: part_of GO:0003164 ! His-Purkinje system development

[Term]
id: GO:0060933
name: His-Purkinje system cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0060932 ! His-Purkinje system cell differentiation

[Term]
id: GO:0060934
name: His-Purkinje system cell fate commitment
namespace: biological_process
def: "The commitment of cells to His-Purkinje cell fates and their capacity to differentiate into His-Purkinje cells. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0060932 ! His-Purkinje system cell differentiation

[Term]
id: GO:0060935
name: cardiac fibroblast cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0035051 ! cardiac cell differentiation

[Term]
id: GO:0060936
name: cardiac fibroblast cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0060935 ! cardiac fibroblast cell differentiation

[Term]
id: GO:0060937
name: cardiac fibroblast cell fate commitment
namespace: biological_process
def: "The commitment of cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0060935 ! cardiac fibroblast cell differentiation

[Term]
id: GO:0060938
name: epicardium-derived cardiac fibroblast cell differentiation
namespace: biological_process
def: "The process whereby an epicardial cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060935 ! cardiac fibroblast cell differentiation

[Term]
id: GO:0060939
name: epicardium-derived cardiac fibroblast cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epicardial-derived cardiac fibroblast over time, from its formation to the mature state. A epicardial-derived cardiac fibroblast is a connective tissue cell of the heart that arises from the epicardium and secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060936 ! cardiac fibroblast cell development
relationship: part_of GO:0060938 ! epicardium-derived cardiac fibroblast cell differentiation

[Term]
id: GO:0060940
name: epithelial to mesenchymal transition involved in cardiac fibroblast development
namespace: biological_process
def: "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will mature into a cardiac fibroblast." [GOC:mtg_heart]
is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition
relationship: part_of GO:0060939 ! epicardium-derived cardiac fibroblast cell development

[Term]
id: GO:0060941
name: epicardium-derived cardiac fibroblast cell fate commitment
namespace: biological_process
def: "The commitment of an epicardial cell to a cardiac fibroblast cell fate and its capacity to differentiate into a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060937 ! cardiac fibroblast cell fate commitment
relationship: part_of GO:0060938 ! epicardium-derived cardiac fibroblast cell differentiation

[Term]
id: GO:0060942
name: neural crest-derived cardiac fibroblast cell differentiation
namespace: biological_process
def: "The process whereby a neural crest cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060935 ! cardiac fibroblast cell differentiation

[Term]
id: GO:0060943
name: neural crest-derived cardiac fibroblast cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation from a neural crest cell to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060936 ! cardiac fibroblast cell development
relationship: part_of GO:0060942 ! neural crest-derived cardiac fibroblast cell differentiation

[Term]
id: GO:0060944
name: neural crest-derived cardiac fibroblast cell fate commitment
namespace: biological_process
def: "The commitment of neural crest cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart]
is_a: GO:0060937 ! cardiac fibroblast cell fate commitment
relationship: part_of GO:0060942 ! neural crest-derived cardiac fibroblast cell differentiation

[Term]
id: GO:0060945
name: cardiac neuron differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron of the heart." [GOC:mtg_heart]
synonym: "heart neuron differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0030182 ! neuron differentiation
is_a: GO:0035051 ! cardiac cell differentiation
relationship: part_of GO:0048483 ! autonomic nervous system development

[Term]
id: GO:0060946
name: cardiac blood vessel endothelial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels." [GOC:mtg_heart]
is_a: GO:0003348 ! cardiac endothelial cell differentiation
is_a: GO:0060837 ! blood vessel endothelial cell differentiation

[Term]
id: GO:0060947
name: cardiac vascular smooth muscle cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers." [GOC:mtg_heart]
synonym: "heart vascular smooth muscle cell differentiation" EXACT [GOC:mtg_heart]
is_a: GO:0035051 ! cardiac cell differentiation
is_a: GO:0051145 ! smooth muscle cell differentiation
relationship: part_of GO:0060976 ! coronary vasculature development

[Term]
id: GO:0060948
name: cardiac vascular smooth muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state." [GOC:mtg_heart]
synonym: "heart vascular smooth muscle cell development" EXACT [GOC:mtg_heart]
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0060947 ! cardiac vascular smooth muscle cell differentiation

[Term]
id: GO:0060949
name: cardiac vascular smooth muscle cell fate commitment
namespace: biological_process
def: "The commitment of cells to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell." [GOC:mtg_heart]
synonym: "heart vascular smooth muscle cell fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0060947 ! cardiac vascular smooth muscle cell differentiation

[Term]
id: GO:0060950
name: cardiac glial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart]
is_a: GO:0010001 ! glial cell differentiation
is_a: GO:0035051 ! cardiac cell differentiation

[Term]
id: GO:0060951
name: neural crest-derived cardiac glial cell differentiation
namespace: biological_process
def: "The process whereby a neural crest cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart]
is_a: GO:0060950 ! cardiac glial cell differentiation

[Term]
id: GO:0060952
name: cardiac glial cell development
namespace: biological_process
def: "The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell." [GOC:mtg_heart]
is_a: GO:0021782 ! glial cell development
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0060950 ! cardiac glial cell differentiation

[Term]
id: GO:0060953
name: cardiac glial cell fate commitment
namespace: biological_process
def: "The commitment of cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells." [GOC:mtg_heart]
is_a: GO:0021781 ! glial cell fate commitment
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0060950 ! cardiac glial cell differentiation

[Term]
id: GO:0060954
name: neural crest-derived cardiac glial cell development
namespace: biological_process
def: "The process aimed at the progression of a neural crest-derived cardiac glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:mtg_heart]
is_a: GO:0060952 ! cardiac glial cell development
relationship: part_of GO:0060951 ! neural crest-derived cardiac glial cell differentiation

[Term]
id: GO:0060955
name: neural crest-derived cardiac glial cell fate commitment
namespace: biological_process
def: "The commitment of neural crest cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells." [GOC:mtg_heart]
is_a: GO:0060953 ! cardiac glial cell fate commitment
relationship: part_of GO:0060951 ! neural crest-derived cardiac glial cell differentiation

[Term]
id: GO:0060956
name: endocardial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]
is_a: GO:0003348 ! cardiac endothelial cell differentiation
is_a: GO:0045446 ! endothelial cell differentiation
relationship: part_of GO:0003157 ! endocardium development

[Term]
id: GO:0060957
name: endocardial cell fate commitment
namespace: biological_process
def: "The commitment of a cell to an endocardial cell fate and its capacity to differentiate into an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart]
is_a: GO:0060839 ! endothelial cell fate commitment
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0060956 ! endocardial cell differentiation

[Term]
id: GO:0060958
name: endocardial cell development
namespace: biological_process
def: "The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart]
is_a: GO:0001885 ! endothelial cell development
relationship: part_of GO:0060956 ! endocardial cell differentiation

[Term]
id: GO:0060959
name: cardiac neuron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state." [GOC:mtg_heart]
synonym: "heart neuron development" EXACT [GOC:mtg_heart]
is_a: GO:0048666 ! neuron development
is_a: GO:0055006 ! cardiac cell development
relationship: part_of GO:0060945 ! cardiac neuron differentiation

[Term]
id: GO:0060960
name: cardiac neuron fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a neuron of the heart." [GOC:mtg_heart]
synonym: "heart neuron fate commitment" EXACT [GOC:mtg_heart]
is_a: GO:0048663 ! neuron fate commitment
is_a: GO:0060911 ! cardiac cell fate commitment
relationship: part_of GO:0060945 ! cardiac neuron differentiation

[Term]
id: GO:0060961
name: phospholipase D inhibitor activity
namespace: molecular_function
def: "Stops, prevents or reduces the activity of a phospholipase D, an enzyme that catalyzes the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [GOC:dph, GOC:tb]
is_a: GO:0004859 ! phospholipase inhibitor activity

[Term]
id: GO:0060962
name: regulation of ribosomal protein gene transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter." [GOC:dph, GOC:tb]
is_a: GO:0010551 ! regulation of gene-specific transcription from RNA polymerase II promoter

[Term]
id: GO:0060963
name: positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II (Pol II), originating at a Pol II-specific promoter." [GOC:dph, GOC:tb]
is_a: GO:0010552 ! positive regulation of gene-specific transcription from RNA polymerase II promoter
is_a: GO:0060962 ! regulation of ribosomal protein gene transcription from RNA polymerase II promoter

[Term]
id: GO:0060964
name: regulation of gene silencing by miRNA
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression." [GOC:dph, GOC:tb]
is_a: GO:0060147 ! regulation of posttranscriptional gene silencing
is_a: GO:0060966 ! regulation of gene silencing by RNA
relationship: regulates GO:0035195 ! gene silencing by miRNA

[Term]
id: GO:0060965
name: negative regulation of gene silencing by miRNA
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression." [GOC:dph, GOC:tb]
is_a: GO:0060149 ! negative regulation of posttranscriptional gene silencing
is_a: GO:0060964 ! regulation of gene silencing by miRNA
is_a: GO:0060967 ! negative regulation of gene silencing by RNA
relationship: negatively_regulates GO:0035195 ! gene silencing by miRNA

[Term]
id: GO:0060966
name: regulation of gene silencing by RNA
namespace: biological_process
def: "Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process by which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb]
is_a: GO:0060968 ! regulation of gene silencing
relationship: regulates GO:0031047 ! gene silencing by RNA

[Term]
id: GO:0060967
name: negative regulation of gene silencing by RNA
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process by which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb]
is_a: GO:0060966 ! regulation of gene silencing by RNA
is_a: GO:0060969 ! negative regulation of gene silencing
relationship: negatively_regulates GO:0031047 ! gene silencing by RNA

[Term]
id: GO:0060968
name: regulation of gene silencing
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0016458 ! gene silencing

[Term]
id: GO:0060969
name: negative regulation of gene silencing
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0060968 ! regulation of gene silencing
relationship: negatively_regulates GO:0016458 ! gene silencing

[Term]
id: GO:0060970
name: embryonic heart tube dorsal/ventral pattern formation
namespace: biological_process
def: "The regionalization process by which the areas along the dorsal/ventral axis of the embryonic heart tube are established. This process will determine the patterns of cell differentiation along the axis." [GOC:mtg_heart]
is_a: GO:0009953 ! dorsal/ventral pattern formation
relationship: part_of GO:0035050 ! embryonic heart tube development

[Term]
id: GO:0060971
name: embryonic heart tube left/right pattern formation
namespace: biological_process
def: "The pattern specification process by which the left/right axis of the embryonic heart tube is subdivided in space to define an area or volume in which specific patterns of cell differentiation will take place." [GOC:mtg_heart]
is_a: GO:0060972 ! left/right pattern formation
relationship: part_of GO:0035050 ! embryonic heart tube development

[Term]
id: GO:0060972
name: left/right pattern formation
namespace: biological_process
def: "The pattern specification process by which the left/right axis is subdivided in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:mtg_heart]
is_a: GO:0003002 ! regionalization

[Term]
id: GO:0060973
name: cell migration involved in heart development
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ." [GOC:mtg_heart]
is_a: GO:0016477 ! cell migration
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0060974
name: cell migration involved in heart formation
namespace: biological_process
def: "The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development

[Term]
id: GO:0060975
name: cardioblast migration to the midline involved in heart field formation
namespace: biological_process
def: "The orderly movement of a cardioblast toward the midline to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]
synonym: "cardiac progenitor cell midline migration" EXACT [GOC:mtg_heart]
synonym: "cardioblast midline convergence" EXACT [GOC:mtg_heart]
is_a: GO:0003260 ! cardioblast migration
is_a: GO:0003318 ! cell migration to the midline involved in heart development
is_a: GO:0060029 ! convergent extension involved in organogenesis

[Term]
id: GO:0060976
name: coronary vasculature development
namespace: biological_process
def: "The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure." [GOC:mtg_heart]
synonym: "cardiac blood vessel development" EXACT [GOC:mtg_heart]
synonym: "cardiac vasculature development" EXACT [GOC:mtg_heart]
synonym: "coronary blood vessel development" EXACT [GOC:mtg_heart]
synonym: "heart blood vessel development" EXACT [GOC:mtg_heart]
synonym: "heart vasculature development" EXACT [GOC:mtg_heart]
is_a: GO:0001568 ! blood vessel development
relationship: part_of GO:0007507 ! heart development

[Term]
id: GO:0060977
name: coronary vasculature morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of blood vessels of the heart are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood." [GOC:mtg_heart]
synonym: "cardiac blood vessel morphogenesis" EXACT [GOC:mtg_heart]
synonym: "cardiac vasculature morphogenesis" EXACT [GOC:mtg_heart]
synonym: "coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart]
synonym: "heart blood vessel morphogenesis" EXACT [GOC:mtg_heart]
synonym: "heart vasculature morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0048514 ! blood vessel morphogenesis
is_a: GO:0060976 ! coronary vasculature development

[Term]
id: GO:0060978
name: angiogenesis involved in coronary vascular morphogenesis
namespace: biological_process
def: "Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels." [GOC:mtg_heart]
synonym: "angiogenesis involved in cardiac vascular morphogenesis" EXACT [GOC:mtg_heart]
synonym: "angiogenesis involved in heart vascular morphogenesis" EXACT [GOC:mtg_heart]
synonym: "coronary blood vessel angiogenesis" EXACT [GOC:mtg_heart]
synonym: "coronary vasculature angiogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0001525 ! angiogenesis
relationship: part_of GO:0060977 ! coronary vasculature morphogenesis

[Term]
id: GO:0060979
name: vasculogenesis involved in coronary vascular morphogenesis
namespace: biological_process
def: "The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes." [GOC:mtg_heart]
synonym: "coronary vasculogenesis" EXACT [GOC:mtg_heart]
synonym: "vasculogenesis involved in coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart]
is_a: GO:0001570 ! vasculogenesis
relationship: part_of GO:0060977 ! coronary vasculature morphogenesis

[Term]
id: GO:0060980
name: cell migration involved in coronary vasculogenesis
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
relationship: part_of GO:0060979 ! vasculogenesis involved in coronary vascular morphogenesis

[Term]
id: GO:0060981
name: cell migration involved in coronary angiogenesis
namespace: biological_process
def: "The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels." [GOC:mtg_heart]
is_a: GO:0060973 ! cell migration involved in heart development
relationship: part_of GO:0060978 ! angiogenesis involved in coronary vascular morphogenesis

[Term]
id: GO:0060982
name: coronary artery morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle." [GOC:mtg_heart]
is_a: GO:0048844 ! artery morphogenesis
is_a: GO:0060977 ! coronary vasculature morphogenesis

[Term]
id: GO:0060983
name: epicardium-derived cardiac vascular smooth muscle cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell derived from the epicardium acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers." [GOC:mtg_heart]
is_a: GO:0060947 ! cardiac vascular smooth muscle cell differentiation

[Term]
id: GO:0060984
name: epicardium-derived cardiac vascular smooth muscle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell that was derived from the epicardium over time, from its formation to the mature state." [GOC:mtg_heart]
is_a: GO:0060948 ! cardiac vascular smooth muscle cell development
relationship: part_of GO:0060983 ! epicardium-derived cardiac vascular smooth muscle cell differentiation

[Term]
id: GO:0060985
name: epicardium-derived cardiac vascular smooth muscle cell fate commitment
namespace: biological_process
def: "The commitment of an epicardial cell to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell." [GOC:mtg_heart]
is_a: GO:0060949 ! cardiac vascular smooth muscle cell fate commitment
relationship: part_of GO:0060983 ! epicardium-derived cardiac vascular smooth muscle cell differentiation

[Term]
id: GO:0060986
name: endocrine hormone secretion
namespace: biological_process
def: "The process by which a hormone is secreted into the circulatory system." [GOC:dph]
is_a: GO:0046879 ! hormone secretion
relationship: part_of GO:0050886 ! endocrine process

[Term]
id: GO:0060987
name: lipid tube
namespace: cellular_component
def: "A macromolecular complex that contains a tube of lipid surrounded by a protein coat." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032994 ! protein-lipid complex

[Term]
id: GO:0060988
name: lipid tube assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as the fuse or undergo fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "lipid tubulation" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0034622 ! cellular macromolecular complex assembly

[Term]
id: GO:0060989
name: lipid tube assembly involved in organelle fusion
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles fuse." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "lipid tubulation involved in organelle fusion" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060988 ! lipid tube assembly
relationship: part_of GO:0048284 ! organelle fusion

[Term]
id: GO:0060990
name: lipid tube assembly involved in organelle fission
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles undergo fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "lipid tubulation involved in organelle fission" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060988 ! lipid tube assembly
relationship: part_of GO:0048285 ! organelle fission

[Term]
id: GO:0060991
name: lipid tube assembly involved in cytokinesis
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in cytokinesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "lipid tubulation involved in cytokinesis" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060988 ! lipid tube assembly
relationship: part_of GO:0000919 ! cell plate assembly

[Term]
id: GO:0060992
name: response to fungicide
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi." [GOC:dph]
is_a: GO:0009636 ! response to toxin

[Term]
id: GO:0060993
name: kidney morphogenesis
namespace: biological_process
def: "Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:kdm_2010]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0060994
name: regulation of transcription from RNA polymerase II promoter involved in kidney development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the kidney progresses from its initial formation to the mature state." [GOC:dph, GOC:kdm_2010]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0060995
name: cell-cell signaling involved in kidney development
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the kidney over time, from its formation to the mature organ." [GOC:dph, GOC:kdm_2010]
is_a: GO:0007267 ! cell-cell signaling
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0060996
name: dendritic spine development
namespace: biological_process
def: "The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0016358 ! dendrite development

[Term]
id: GO:0060997
name: dendritic spine morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
is_a: GO:0032990 ! cell part morphogenesis
relationship: part_of GO:0048813 ! dendrite morphogenesis
relationship: part_of GO:0060996 ! dendritic spine development

[Term]
id: GO:0060998
name: regulation of dendritic spine development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0050773 ! regulation of dendrite development
relationship: regulates GO:0060996 ! dendritic spine development

[Term]
id: GO:0060999
name: positive regulation of dendritic spine development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0060998 ! regulation of dendritic spine development
relationship: positively_regulates GO:0060996 ! dendritic spine development

[Term]
id: GO:0061000
name: negative regulation of dendritic spine development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0060998 ! regulation of dendritic spine development
relationship: negatively_regulates GO:0060996 ! dendritic spine development

[Term]
id: GO:0061001
name: regulation of dendritic spine morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process by which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
is_a: GO:0048814 ! regulation of dendrite morphogenesis
is_a: GO:0060998 ! regulation of dendritic spine development
relationship: regulates GO:0060997 ! dendritic spine morphogenesis

[Term]
id: GO:0061002
name: negative regulation of dendritic spine morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process by which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0061000 ! negative regulation of dendritic spine development
is_a: GO:0061001 ! regulation of dendritic spine morphogenesis
relationship: negatively_regulates GO:0060997 ! dendritic spine morphogenesis

[Term]
id: GO:0061003
name: positive regulation of dendritic spine morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process by which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0060999 ! positive regulation of dendritic spine development
is_a: GO:0061001 ! regulation of dendritic spine morphogenesis

[Term]
id: GO:0061004
name: pattern specification involved in kidney development
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within the kidney to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:kdm_2010]
synonym: "kidney pattern formation" RELATED [GOC:mtg_kidney_jan10]
synonym: "kidney pattern specification" EXACT [GOC:mtg_kidney_jan10]
synonym: "pattern formation involved in kidney development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072048 ! renal system pattern specification
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0061005
name: cell differentiation involved in kidney development
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state." [GOC:dph, GOC:mtg_kidney_jan10]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0061006
name: regulation of cell proliferation involved in kidney morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell proliferation that contributes to the shaping of the kidney." [GOC:dph, GOC:kdm_2010]
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0060993 ! kidney morphogenesis

[Term]
id: GO:0061007
name: hepaticobiliary system process
namespace: biological_process
def: "An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph]
synonym: "hepatobiliary system process" EXACT [GOC:dph]
is_a: GO:0003008 ! system process

[Term]
id: GO:0061008
name: hepaticobiliary system development
namespace: biological_process
def: "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph]
synonym: "hepatobiliary system development" EXACT [GOC:dph]
is_a: GO:0048731 ! system development

[Term]
id: GO:0061009
name: bile duct development
namespace: biological_process
def: "The progression of the bile duct over time, from its formation to the mature structure. The bile duct is the duct that runs from the liver and gall bladder to the intestine." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061008 ! hepaticobiliary system development

[Term]
id: GO:0061010
name: gall bladder development
namespace: biological_process
def: "The progression of the gall bladder over time, from its initial formation to the mature structure. The gall bladder is a cavitated organ that stores bile." [GOD:dph]
is_a: GO:0048513 ! organ development
relationship: part_of GO:0061008 ! hepaticobiliary system development

[Term]
id: GO:0061011
name: hepatic duct development
namespace: biological_process
def: "The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the bile duct." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0061008 ! hepaticobiliary system development

[Term]
id: GO:0061013
name: regulation of mRNA catabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of mRNA decay" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0031329 ! regulation of cellular catabolic process
is_a: GO:0051252 ! regulation of RNA metabolic process
relationship: regulates GO:0006402 ! mRNA catabolic process

[Term]
id: GO:0061014
name: positive regulation of mRNA catabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "positive regulation of mRNA decay" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0031331 ! positive regulation of cellular catabolic process
is_a: GO:0051254 ! positive regulation of RNA metabolic process
is_a: GO:0061013 ! regulation of mRNA catabolic process
relationship: positively_regulates GO:0006402 ! mRNA catabolic process

[Term]
id: GO:0061015
name: snRNA import into nucleus
namespace: biological_process
def: "The directed movement of snRNA, small nuclear ribonucleic acid into the nucleus." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051030 ! snRNA transport

[Term]
id: GO:0061016
name: snRNA import into Cajal body
namespace: biological_process
def: "The directed movement of snRNA, small nuclear ribonucleic acid, into a Cajal body." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051030 ! snRNA transport

[Term]
id: GO:0061017
name: hepatoblast differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes." [GOC:dph, PMID:15226394]
is_a: GO:0048863 ! stem cell differentiation
relationship: part_of GO:0001889 ! liver development

[Term]
id: GO:0061024
name: membrane organization
namespace: biological_process
def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb]
is_a: GO:0016043 ! cellular component organization

[Term]
id: GO:0061025
name: membrane fusion
namespace: biological_process
def: "The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb]
is_a: GO:0061024 ! membrane organization

[Term]
id: GO:0061026
name: cardiac muscle tissue regeneration
namespace: biological_process
def: "The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:dph]
is_a: GO:0042246 ! tissue regeneration

[Term]
id: GO:0061027
name: umbilical cord development
namespace: biological_process
def: "The process whose specific outcome is the development of the umbilical cord, from its formation to the mature structure. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta." [GOC:BHF, GOC:dph]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0061028
name: establishment of endothelial barrier
namespace: biological_process
def: "The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition." [GOC:dph]
is_a: GO:0001885 ! endothelial cell development

[Term]
id: GO:0061029
name: eyelid development in camera-type eye
namespace: biological_process
def: "The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0043010 ! camera-type eye development

[Term]
id: GO:0061030
name: epithelial cell differentiation involved in mammary gland alveolus development
namespace: biological_process
def: "The process by which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus." [GOC:dph]
is_a: GO:0060644 ! mammary gland epithelial cell differentiation
relationship: part_of GO:0060749 ! mammary gland alveolus development

[Term]
id: GO:0061031
name: endodermal gut morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the endodermal gut are generated and organized. Morphogenesis pertains to the creation of form. The endodermal gut includes those portions of the gut that are derived from endoderm." [GOC:dph]
is_a: GO:0048547 ! gut morphogenesis

[Term]
id: GO:0061032
name: visceral serous pericardium development
namespace: biological_process
def: "The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium." [GOC:dph]
synonym: "epicardium development" EXACT [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0060039 ! pericardium development

[Term]
id: GO:0061033
name: secretion by lung epithelial cell involved in lung growth
namespace: biological_process
def: "The controlled release of liquid by a lung epithelial cell that contributes to an increase in size of the lung as part of its development." [GOC:dph]
synonym: "fetal lung liquid secretion" RELATED [GOC:dph]
is_a: GO:0032940 ! secretion by cell
relationship: part_of GO:0060437 ! lung growth

[Term]
id: GO:0061034
name: olfactory bulb mitral cell layer development
namespace: biological_process
def: "The progression of the olfactory bulb mitral cell layer over time from its initial formation until its mature state. The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer." [GOC:dph]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021772 ! olfactory bulb development

[Term]
id: GO:0061035
name: regulation of cartilage development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0051216 ! cartilage development

[Term]
id: GO:0061036
name: positive regulation of cartilage development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0061035 ! regulation of cartilage development
relationship: positively_regulates GO:0051216 ! cartilage development

[Term]
id: GO:0061037
name: negative regulation of cartilage development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0061035 ! regulation of cartilage development
relationship: negatively_regulates GO:0051216 ! cartilage development

[Term]
id: GO:0061038
name: uterus morphogenesis
namespace: biological_process
def: "The process by which anatomical structures of the uterus are generated and organized." [GOC:BHF, GOC:dph]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0060065 ! uterus development

[Term]
id: GO:0061039
name: ovum-producing ovary development
namespace: biological_process
def: "The process whose specific outcome is the progression of an ovary that produces an ovum over time, from its formation to the mature structure." [GOC:dph]
is_a: GO:0048513 ! organ development
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0061040
name: ovum-producing ovary morphogenesis
namespace: biological_process
def: "The process by which an ovum-producing ovary is generated and organized." [GOC:BHF, GOC:dph]
is_a: GO:0009887 ! organ morphogenesis
relationship: part_of GO:0061039 ! ovum-producing ovary development

[Term]
id: GO:0061041
name: regulation of wound healing
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF, GOC:dph]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0042060 ! wound healing

[Term]
id: GO:0061042
name: vascular wound healing
namespace: biological_process
def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:BHF, GOC:dph]
is_a: GO:0060055 ! angiogenesis involved in wound healing

[Term]
id: GO:0061043
name: regulation of vascular wound healing
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:dph]
is_a: GO:0045765 ! regulation of angiogenesis
is_a: GO:0061041 ! regulation of wound healing
relationship: regulates GO:0061042 ! vascular wound healing

[Term]
id: GO:0061044
name: negative regulation of vascular wound healing
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:BHF, GOC:dph]
is_a: GO:0016525 ! negative regulation of angiogenesis
is_a: GO:0061043 ! regulation of vascular wound healing
is_a: GO:0061045 ! negative regulation of wound healing
relationship: negatively_regulates GO:0061042 ! vascular wound healing

[Term]
id: GO:0061045
name: negative regulation of wound healing
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph]
is_a: GO:0032102 ! negative regulation of response to external stimulus
is_a: GO:0061041 ! regulation of wound healing
relationship: negatively_regulates GO:0042060 ! wound healing

[Term]
id: GO:0061046
name: regulation of branching involved in lung morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process whereby a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
relationship: regulates GO:0060441 ! branching involved in lung morphogenesis

[Term]
id: GO:0061047
name: positive regulation of branching involved in lung morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process whereby a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis
relationship: positively_regulates GO:0060441 ! branching involved in lung morphogenesis

[Term]
id: GO:0061048
name: negative regulation of branching involved in lung morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the process whereby a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis
relationship: negatively_regulates GO:0060441 ! branching involved in lung morphogenesis

[Term]
id: GO:0061049
name: cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
synonym: "cardiac muscle cell hypertrophy" RELATED [GOC:dph]
synonym: "cardiomyocyte growth" RELATED [GOC:dph]
synonym: "heart muscle cell growth" RELATED [GOD:dph]
is_a: GO:0048588 ! developmental cell growth
relationship: part_of GO:0003301 ! physiological cardiac muscle hypertrophy
relationship: part_of GO:0055013 ! cardiac muscle cell development

[Term]
id: GO:0061050
name: regulation of cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
is_a: GO:0001558 ! regulation of cell growth
is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy
is_a: GO:0051153 ! regulation of striated muscle cell differentiation
is_a: GO:0055021 ! regulation of cardiac muscle tissue growth
relationship: regulates GO:0061049 ! cell growth involved in cardiac muscle cell development

[Term]
id: GO:0061051
name: positive regulation of cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
is_a: GO:0010613 ! positive regulation of cardiac muscle hypertrophy
is_a: GO:0030307 ! positive regulation of cell growth
is_a: GO:0048639 ! positive regulation of developmental growth
is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation
is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth
is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development
relationship: positively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development

[Term]
id: GO:0061052
name: negative regulation of cell growth involved in cardiac muscle cell development
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph]
is_a: GO:0010614 ! negative regulation of cardiac muscle hypertrophy
is_a: GO:0030308 ! negative regulation of cell growth
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation
is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth
is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development
relationship: negatively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development

[Term]
id: GO:0065001
name: specification of axis polarity
namespace: biological_process
def: "The pattern specification process by which the polarity of a body or organ axis is established and maintained." [GOC:mah]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0009798 ! axis specification

[Term]
id: GO:0065002
name: intracellular protein transmembrane transport
namespace: biological_process
def: "The directed movement of proteins in a cell, from one side of a membrane to another." [GOC:isa_complete]
synonym: "intracellular membrane translocation of a protein" EXACT []
synonym: "intracellular protein transport across a membrane" EXACT []
is_a: GO:0006886 ! intracellular protein transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0065003
name: macromolecular complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a complex." [GOC:jl]
subset: goslim_pir
subset: gosubset_prok
synonym: "macromolecule complex assembly" EXACT []
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0043933 ! macromolecular complex subunit organization

[Term]
id: GO:0065004
name: protein-DNA complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl]
subset: gosubset_prok
synonym: "DNA-protein complex assembly" EXACT [GOC:mah]
is_a: GO:0034622 ! cellular macromolecular complex assembly

[Term]
id: GO:0065005
name: protein-lipid complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex." [GOC:jl]
subset: gosubset_prok
is_a: GO:0065003 ! macromolecular complex assembly

[Term]
id: GO:0065006
name: protein-carbohydrate complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins and carbohydrates to form a protein-carbohydrate complex." [GOC:jl]
subset: gosubset_prok
is_a: GO:0065003 ! macromolecular complex assembly

[Term]
id: GO:0065007
name: biological regulation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any biological process, quality or function." [GOC:isa_complete]
subset: goslim_pir
subset: gosubset_prok
synonym: "regulation" BROAD []
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0065008
name: regulation of biological quality
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:isa_complete]
subset: gosubset_prok
synonym: "regulation of biological attribute" EXACT []
synonym: "regulation of biological characteristic" EXACT []
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0065009
name: regulation of molecular function
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete]
subset: gosubset_prok
synonym: "regulation of a molecular function" EXACT []
is_a: GO:0065007 ! biological regulation

[Term]
id: GO:0065010
name: extracellular membrane-bounded organelle
namespace: cellular_component
def: "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete]
synonym: "extracellular membrane-enclosed organelle" EXACT []
is_a: GO:0043227 ! membrane-bounded organelle
is_a: GO:0043230 ! extracellular organelle

[Term]
id: GO:0070001
name: aspartic-type peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE]
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0070002
name: glutamic-type peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE]
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0070003
name: threonine-type peptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE]
is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides

[Term]
id: GO:0070004
name: cysteine-type exopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#EXOPEPTIDASE]
is_a: GO:0008234 ! cysteine-type peptidase activity
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0070005
name: cysteine-type aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE]
xref: EC:3.4.18
is_a: GO:0004177 ! aminopeptidase activity
is_a: GO:0070004 ! cysteine-type exopeptidase activity

[Term]
id: GO:0070006
name: metalloaminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of N-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE]
is_a: GO:0004177 ! aminopeptidase activity
is_a: GO:0008235 ! metalloexopeptidase activity

[Term]
id: GO:0070007
name: glutamic-type endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE]
is_a: GO:0004175 ! endopeptidase activity
is_a: GO:0070002 ! glutamic-type peptidase activity

[Term]
id: GO:0070008
name: serine-type exopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#EXOPEPTIDASE, ISBN:0716720094]
subset: gosubset_prok
xref: EC:3.4.21
is_a: GO:0008236 ! serine-type peptidase activity
is_a: GO:0008238 ! exopeptidase activity

[Term]
id: GO:0070009
name: serine-type aminopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#AMINOPEPTIDASE, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, ISBN:0716720094]
is_a: GO:0004177 ! aminopeptidase activity
is_a: GO:0070008 ! serine-type exopeptidase activity

[Term]
id: GO:0070010
name: peptidase activity, acting on D-amino acid peptides
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds formed between D-amino acids." [GOC:mah]
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0070011
name: peptidase activity, acting on L-amino acid peptides
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds formed between L-amino acids." [GOC:mah]
subset: gosubset_prok
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0070012
name: oligopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0070013
name: intracellular organelle lumen
namespace: cellular_component
def: "An organelle lumen that is part of an intracellular organelle." [GOC:mah]
is_a: GO:0043233 ! organelle lumen
is_a: GO:0044446 ! intracellular organelle part

[Term]
id: GO:0070014
name: sucrase-isomaltase complex
namespace: cellular_component
def: "A protein complex that possesses oligo-1,6-glucosidase activity; the complex is a heterodimer located in the cell membrane, and is formed by proteolytic cleavage of a single precursor polypeptide. The two subunits have different substrate specificities." [PMID:3366777]
synonym: "oligo-1,6-glucosidase complex" RELATED []
xref: Wikipedia:Sucrase-isomaltase
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0070016
name: armadillo repeat domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the armadillo repeat domain of a protein, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation." [GOC:BHF, GOC:mah, GOC:vk, InterPro:IPR000225]
synonym: "Arm repeat domain binding" EXACT []
synonym: "armadillo domain binding" EXACT []
synonym: "armadillo repeat binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070017
name: alphav-beta3 integrin-thrombospondin complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to thrombospondin." [PMID:2478219]
synonym: "ITGAV-ITGB3-THBS1 complex" NARROW [CORUM:2846]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070018
name: transforming growth factor beta type I receptor complex
namespace: cellular_component
def: "A receptor complex that consists of two transforming growth factor beta (TGF-beta) type I receptor monomers. TGF-beta type I receptor dimers form in the presence or absence of ligand, and can associate with ligand-bound TGF-beta type II receptor dimers." [Reactome:REACT_7737]
synonym: "TGF-beta type I receptor complex" EXACT []
synonym: "TGF-beta type I receptor dimer" EXACT [Reactome:REACT_7737]
is_a: GO:0070022 ! transforming growth factor beta receptor complex

[Term]
id: GO:0070019
name: transforming growth factor beta type II receptor complex
namespace: cellular_component
def: "A receptor complex that consists of two transforming growth factor beta (TGF-beta) type II receptor monomers. TGF-beta type II receptor dimers form in the presence or absence of ligand, and upon ligand binding can associate with TGF-beta type I receptor dimers." [Reactome:REACT_7415]
synonym: "TGF-beta type II receptor complex" EXACT []
synonym: "TGF-beta type II receptor dimer" EXACT [Reactome:REACT_7415]
is_a: GO:0070022 ! transforming growth factor beta receptor complex

[Term]
id: GO:0070020
name: transforming growth factor beta1-type II receptor complex
namespace: cellular_component
def: "A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer." [Reactome:REACT_7218]
subset: goslim_pir
synonym: "TGF-beta receptor II-TGF-beta1 complex" EXACT []
synonym: "TGF-beta1-type II receptor complex" EXACT [Reactome:REACT_7218]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070021
name: transforming growth factor beta1-type II receptor-type I receptor complex
namespace: cellular_component
def: "A protein complex that is formed by the association of a ligand-bound TGF-beta type II receptor dimer with a TGF-beta type I receptor dimer." [Reactome:REACT_7425]
subset: goslim_pir
synonym: "TGF-beta 1:type II receptor:type I receptor complex" EXACT [Reactome:REACT_7425]
synonym: "TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex" EXACT []
synonym: "TGF-beta1-type II receptor-type I receptor complex" EXACT []
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070022
name: transforming growth factor beta receptor complex
namespace: cellular_component
def: "A dimeric receptor complex that binds transforming growth factor beta (TGF-beta); consists of two TGF-beta receptor monomers." [GOC:mah, Reactome:REACT_7415, Reactome:REACT_7737]
synonym: "TGF-beta receptor complex" EXACT []
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0070023
name: interleukin12-interleukin-12 receptor complex
namespace: cellular_component
def: "A protein complex that is formed by the association of a heterodimeric interleukin-12 receptor complex with an interleukin-12 heterodimer." [PMID:11900991]
subset: goslim_pir
synonym: "IL12-IL12 receptor complex" EXACT []
synonym: "IL12B-IL12RB1-IL12RB2 complex" NARROW [CORUM:2020]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070024
name: CD19-Vav-PIK3R1 complex
namespace: cellular_component
def: "A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K)." [PMID:7528218]
subset: goslim_pir
synonym: "CD19-Vav-PI 3-kinase (p85 subunit) complex" EXACT [CORUM:2574]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070025
name: carbon monoxide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with carbon monoxide (CO)." [GOC:ecd]
subset: gosubset_prok
synonym: "CO binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0070026
name: nitric oxide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with nitric oxide (NO)." [GOC:ecd]
subset: gosubset_prok
synonym: "nitrogen monoxide binding" EXACT []
synonym: "nitrosyl binding" EXACT [ChEBI:16480]
synonym: "NO binding" EXACT []
is_a: GO:0005488 ! binding

[Term]
id: GO:0070027
name: carbon monoxide sensor activity
namespace: molecular_function
def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of carbon monoxide (CO)." [GOC:ecd]
is_a: GO:0070025 ! carbon monoxide binding

[Term]
id: GO:0070028
name: regulation of transcription by carbon monoxide
namespace: biological_process
def: "Any process involving carbon monoxide that modulates the frequency, rate or extent of transcription." [GOC:ecd]
subset: gosubset_prok
synonym: "regulation of transcription by CO" EXACT []
is_a: GO:0006355 ! regulation of transcription, DNA-dependent
is_a: GO:0071245 ! cellular response to carbon monoxide

[Term]
id: GO:0070029
name: alphav-beta3 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin." [PMID:7532190]
synonym: "ITGAV-ITGB3-SPP1 complex" NARROW [CORUM:2358]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070030
name: alphav-beta1 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta1 integrin complex bound to osteopontin." [PMID:7592829]
synonym: "ITGAV-ITGB1-SPP1 complex" NARROW [CORUM:2885]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070031
name: alphav-beta5 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin." [PMID:7592829]
synonym: "ITGAV-ITGB5-SPP1 complex" NARROW [CORUM:2347]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070032
name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof)." [PMID:7553862]
synonym: "SNARE complex (Vamp2, Snap25, Stx1a, Cplx1)" NARROW [CORUM:795]
synonym: "Vamp2-Snap25-Stx1a-Cplx1 complex" NARROW [CORUM:795]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070033
name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof)." [PMID:7553862]
synonym: "SNARE complex (Vamp2, Snap25, Stx1a, Cplx2)" NARROW [CORUM:796]
synonym: "Vamp2-Snap25-Stx1a-Cplx2 complex" NARROW [CORUM:796]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070034
name: telomeric RNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the telomerase RNA template or to RNA complementary to it." [GOC:krc, PMID:16884717]
synonym: "telomeric RNA repeat binding" NARROW []
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0070035
name: purine NTP-dependent helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate to drive the unwinding of a DNA or RNA helix." [GOC:mah]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
is_a: GO:0004386 ! helicase activity

[Term]
id: GO:0070036
name: GTP-dependent helicase activity
namespace: molecular_function
def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate to drive the unwinding of a DNA or RNA helix." [GOC:mah]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
is_a: GO:0042623 ! ATPase activity, coupled
is_a: GO:0070035 ! purine NTP-dependent helicase activity

[Term]
id: GO:0070037
name: rRNA (pseudouridine) methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule." [GOC:imk, GOC:mah]
subset: gosubset_prok
is_a: GO:0008649 ! rRNA methyltransferase activity

[Term]
id: GO:0070038
name: rRNA (pseudouridine-N3-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine." [GOC:imk, GOC:mah]
subset: gosubset_prok
is_a: GO:0070037 ! rRNA (pseudouridine) methyltransferase activity

[Term]
id: GO:0070039
name: rRNA (guanosine-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine." [GOC:imk, GOC:mah]
subset: gosubset_prok
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity

[Term]
id: GO:0070040
name: rRNA (adenine-C2-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C2-methyladenine." [GOC:imk, GOC:mah]
subset: gosubset_prok
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity

[Term]
id: GO:0070041
name: rRNA (uridine-C5-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C5-methyluridine." [GOC:imk, GOC:mah]
subset: gosubset_prok
is_a: GO:0008169 ! C-methyltransferase activity
is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity

[Term]
id: GO:0070042
name: rRNA (uridine-N3-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine." [GOC:imk, GOC:mah]
subset: gosubset_prok
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity

[Term]
id: GO:0070043
name: rRNA (guanine-N7-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine." [GOC:imk, GOC:mah]
subset: gosubset_prok
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity

[Term]
id: GO:0070044
name: synaptobrevin 2-SNAP-25-syntaxin-1a complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof)." [PMID:10336434]
synonym: "Snap25-Stx1a-Vamp2 complex" NARROW []
synonym: "SNARE complex (Snap25, Stx1a, Vamp2)" NARROW [CORUM:998]
synonym: "SNARE complex (Stx1a, SNAP25, VAMP)" NARROW [CORUM:841]
synonym: "Stx1a-SNAP25-VAMP complex" NARROW [CORUM:841]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070045
name: synaptobrevin 2-SNAP-25-syntaxin-2 complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 2 (or orthologs thereof)." [PMID:10336434]
synonym: "SNARE complex (Stx2, Snap25, Vamp2)" NARROW [CORUM:851]
synonym: "Stx2-Snap25-Vamp2 complex" NARROW [CORUM:851]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070046
name: synaptobrevin 2-SNAP-25-syntaxin-3 complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 3 (or orthologs thereof)." [PMID:10336434]
synonym: "SNARE complex (Stx3, Snap25, Vamp2)" NARROW [CORUM:852]
synonym: "Stx3-Snap25-Vamp2 complex" NARROW [CORUM:852]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070047
name: synaptobrevin 2-SNAP-25-syntaxin-4 complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof)." [PMID:10336434]
synonym: "SNARE complex (Stx4, Snap25, Vamp2)" NARROW [CORUM:853]
synonym: "Stx4-Snap25-Vamp2 complex" NARROW [CORUM:853]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070048
name: endobrevin-SNAP-25-syntaxin-1a complex
namespace: cellular_component
def: "A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 1a (or orthologs thereof)." [PMID:10336434]
synonym: "SNARE complex (Stx1a, Snap25, Vamp8)" NARROW [CORUM:854]
synonym: "Stx1a-Snap25-Vamp8 complex" NARROW [CORUM:854]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070049
name: endobrevin-SNAP-25-syntaxin-2 complex
namespace: cellular_component
def: "A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 2 (or orthologs thereof)." [PMID:10336434]
synonym: "SNARE complex (Stx2, Snap25, Vamp8)" NARROW [CORUM:855]
synonym: "Stx2-Snap25-Vamp8 complex" NARROW [CORUM:855]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070050
name: neuron homeostasis
namespace: biological_process
def: "The cellular homeostatic process by which a neuron is preserved in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah]
synonym: "neuron maintenance" EXACT []
is_a: GO:0019725 ! cellular homeostasis
is_a: GO:0060249 ! anatomical structure homeostasis

[Term]
id: GO:0070051
name: fibrinogen binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade." [GOC:BHF, GOC:mah, GOC:vk]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0070052
name: collagen V binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type V collagen." [GOC:BHF, GOC:mah]
is_a: GO:0005518 ! collagen binding

[Term]
id: GO:0070053
name: thrombospondin receptor activity
namespace: molecular_function
def: "Combining with thrombospondin to initiate a change in cell activity." [GOC:BHF, GOC:vk]
is_a: GO:0004872 ! receptor activity

[Term]
id: GO:0070054
name: mRNA splicing, via endonucleolytic cleavage and ligation
namespace: biological_process
alt_id: GO:0061012
def: "Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, GOC:mah]
comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis.
subset: gosubset_prok
synonym: "cytosolic mRNA splicing" RELATED [GOC:curators]
is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation
is_a: GO:0006397 ! mRNA processing

[Term]
id: GO:0070055
name: HAC1-type intron splice site recognition and cleavage
namespace: biological_process
def: "The process by which the tertiary structure of a HAC1 type intron is recognized, and the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, PMID:10357823]
subset: gosubset_prok
is_a: GO:0006396 ! RNA processing
relationship: part_of GO:0070054 ! mRNA splicing, via endonucleolytic cleavage and ligation

[Term]
id: GO:0070056
name: prospore membrane leading edge
namespace: cellular_component
def: "The region of the prospore membrane that extends to surround the spore nucleus; coated with specific proteins that are thought to play a role in prospore membrane organization." [GOC:mah, PMID:14702385]
synonym: "forespore membrane leading edge" EXACT []
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0005628 ! prospore membrane

[Term]
id: GO:0070057
name: prospore membrane spindle pole body attachment site
namespace: cellular_component
def: "The region of the prospore membrane to which the spindle pole body (SPB) is anchored; the prospore membrane extends from the SPB attachment site to surround the spore nucleus." [GOC:mah, PMID:14702385]
synonym: "forespore membrane SPB attachment site" EXACT []
synonym: "forespore membrane spindle pole body attachment site" EXACT []
synonym: "prospore membrane SPB attachment site" EXACT []
is_a: GO:0044425 ! membrane part
relationship: part_of GO:0005628 ! prospore membrane

[Term]
id: GO:0070058
name: tRNA gene clustering
namespace: biological_process
def: "The process by which tRNA genes, which are not linearly connected on the chromosome, are transported in three dimensions to, and maintained together in, the nucleolus. This clustered positioning leads to transcriptional silencing of nearby RNA polymerase II promoters (termed tRNA gene mediated (tgm) silencing) in S. cerevisiae." [GOC:jh, GOC:mah, PMID:18708579]
is_a: GO:0051276 ! chromosome organization
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0070059
name: apoptosis in response to endoplasmic reticulum stress
namespace: biological_process
def: "Apoptosis that occurs in response to a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, PMID:18701708]
synonym: "apoptosis in response to ER stress" EXACT []
synonym: "apoptosis triggered by ER stress" EXACT []
synonym: "endoplasmic reticulum stress-induced apoptosis" EXACT []
synonym: "ER stress-induced apoptosis" EXACT []
is_a: GO:0006915 ! apoptosis

[Term]
id: GO:0070060
name: 'de novo' actin filament nucleation
namespace: biological_process
def: "The actin nucleation process by which actin monomers combine in the absence of any existing actin filaments; elongation of the actin oligomer formed by nucleation leads to the formation of an unbranched filament." [GOC:mah, PMID:17477841]
synonym: "formin-mediated actin filament nucleation" NARROW []
synonym: "unbranched actin filament nucleation" RELATED []
is_a: GO:0045010 ! actin nucleation

[Term]
id: GO:0070061
name: fructose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose." [ChEBI:28757, GOC:BHF, GOC:mah]
subset: gosubset_prok
is_a: GO:0048029 ! monosaccharide binding

[Term]
id: GO:0070062
name: extracellular vesicular exosome
namespace: cellular_component
def: "A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:BHF, GOC:mah, PMID:15908444, PMID:17641064]
is_a: GO:0031988 ! membrane-bounded vesicle
is_a: GO:0065010 ! extracellular membrane-bounded organelle

[Term]
id: GO:0070063
name: RNA polymerase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an RNA polymerase." [GOC:BHF, GOC:mah]
subset: gosubset_prok
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0070064
name: proline-rich region binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein." [GOC:mah]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0070065
name: cellubrevin-VAMP4-syntaxin-16 complex
namespace: cellular_component
def: "A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof)." [PMID:11839770]
synonym: "SNARE complex (Vamp3, Vamp4, Stx16)" NARROW [CORUM:875]
synonym: "Vamp3-Vamp4-Stx16 complex" NARROW [CORUM:875]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070066
name: cellubrevin-VAMP4-endobrevin-syntaxin-6 complex
namespace: cellular_component
def: "A SNARE complex that contains cellubrevin (VAMP3), VAMP4, endobrevin (VAMP8), and syntaxin 6 (or orthologs thereof)." [PMID:11839770]
synonym: "SNARE complex (Vamp3, Vamp4, Vam8, Stx6)" NARROW [CORUM:874]
synonym: "Vamp3-Vamp4-Vam8-Stx6 complex" NARROW [CORUM:874]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070067
name: syntaxin-6-syntaxin-16-Vti1a complex
namespace: cellular_component
def: "A SNARE complex that contains syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof)." [PMID:11839770]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070068
name: VAMP4-syntaxin-6-syntaxin-16-Vti1a complex
namespace: cellular_component
def: "A SNARE complex that contains VAMP4, syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof)." [PMID:11839770]
synonym: "SNARE complex (Vamp4, Stx6, Stx16, Vti1a)" NARROW [CORUM:877]
synonym: "Vamp4-Stx6-Stx16-Vti1a complex" RELATED [CORUM:877]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070069
name: cytochrome complex
namespace: cellular_component
def: "A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:mah]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0070070
name: proton-transporting V-type ATPase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient." [GOC:mah]
synonym: "V-ATPase assembly" RELATED []
synonym: "V-ATPase complex assembly" RELATED []
is_a: GO:0070071 ! proton-transporting two-sector ATPase complex assembly

[Term]
id: GO:0070071
name: proton-transporting two-sector ATPase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane." [GOC:mah]
subset: gosubset_prok
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0070072
name: vacuolar proton-transporting V-type ATPase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane." [GOC:BHF, GOC:mah]
synonym: "V-ATPase assembly" BROAD []
synonym: "V-ATPase complex assembly" BROAD []
is_a: GO:0070070 ! proton-transporting V-type ATPase complex assembly

[Term]
id: GO:0070073
name: clustering of voltage-gated calcium channels
namespace: biological_process
def: "The process by which voltage-gated calcium channels become localized together in high densities." [GOC:BHF, GOC:sart, PMID:183853250]
synonym: "clustering of voltage gated calcium channels" EXACT []
synonym: "clustering of voltage-dependent calcium channels" EXACT []
synonym: "voltage-gated calcium channel clustering" EXACT []
is_a: GO:0045161 ! neuronal ion channel clustering

[Term]
id: GO:0070074
name: mononeme
namespace: cellular_component
def: "A secretory organelle that forms part of the apical complex; a small, threadlike structure located is close proximity to the subpellicular microtubules. Its contents include a rhomboid protease (PfROM1 in Plasmodium falciparum) that moves from the lateral asymmetric localization to the merozoite apical pole and the posterior pole upon release of merozoites from schizonts." [GOC:BHF, PMID:18048320]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
relationship: part_of GO:0020007 ! apical complex

[Term]
id: GO:0070075
name: tear secretion
namespace: biological_process
def: "The regulated release of the aqueous layer of the tear film from the lacrimal glands. Tears are the liquid product of a process of lacrimation to clean and lubricate the eyes. Tear fluid contains water, mucin, lipids, lysozyme, lactoferrin, lipocalin, lacritin, immunoglobulins, glucose, urea, sodium, and potassium." [GOC:rph]
is_a: GO:0007589 ! body fluid secretion

[Term]
id: GO:0070076
name: histone lysine demethylation
namespace: biological_process
def: "The modification of a histone by the removal of a methyl group from a lysine residue." [GOC:mah]
is_a: GO:0016577 ! histone demethylation

[Term]
id: GO:0070077
name: histone arginine demethylation
namespace: biological_process
def: "The modification of a histone by the removal of a methyl group from an arginine residue." [GOC:mah]
is_a: GO:0016577 ! histone demethylation

[Term]
id: GO:0070078
name: histone H3-R2 demethylation
namespace: biological_process
def: "The modification of histone H3 by the removal of a methyl group from arginine at position 2 of the histone." [GOC:vk]
is_a: GO:0070077 ! histone arginine demethylation

[Term]
id: GO:0070079
name: histone H4-R3 demethylation
namespace: biological_process
def: "The modification of histone H4 by the removal of a methyl group from arginine at position 3 of the histone." [GOC:vk]
is_a: GO:0070077 ! histone arginine demethylation

[Term]
id: GO:0070080
name: titin Z domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the titin Z domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34." [GOC:mah, InterPro:IPR015129]
synonym: "Z repeat domain binding" EXACT []
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070081
name: clathrin sculpted monoamine transport vesicle
namespace: cellular_component
def: "A clathrin sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing monoamines." [GOC:mg2]
is_a: GO:0030133 ! transport vesicle
is_a: GO:0060198 ! clathrin sculpted vesicle

[Term]
id: GO:0070082
name: clathrin sculpted monoamine transport vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of the clathrin sculpted monoamine transport vesicle." [GOC:mg2]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0070081 ! clathrin sculpted monoamine transport vesicle

[Term]
id: GO:0070083
name: clathrin sculpted monoamine transport vesicle membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a clathrin sculpted monoamine transport vesicle." [GOC:mg2]
is_a: GO:0030658 ! transport vesicle membrane
is_a: GO:0030665 ! clathrin coated vesicle membrane
relationship: part_of GO:0070081 ! clathrin sculpted monoamine transport vesicle

[Term]
id: GO:0070084
name: protein initiator methionine removal
namespace: biological_process
def: "The post-translational protein modification process by which the translation-initiating methionine or formylmethionine residue is removed from a protein." [GOC:imk, GOC:mah]
synonym: "removal of initiator methionine from protein" EXACT []
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0070085
name: glycosylation
namespace: biological_process
def: "The covalent attachment of a glycosyl residue to a substrate molecule." [GOC:mah]
xref: Wikipedia:Glycosylation
is_a: GO:0005975 ! carbohydrate metabolic process

[Term]
id: GO:0070086
name: ubiquitin-dependent endocytosis
namespace: biological_process
def: "Endocytosis of a protein that requires the substrate to be modified by uniquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded." [GOC:jp, GOC:mah, PMID:9409540]
synonym: "ubiquitin-mediated endocytosis" EXACT [GOC:jp]
is_a: GO:0006897 ! endocytosis

[Term]
id: GO:0070087
name: chromo shadow domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain." [GOC:BHF, GOC:vk, InterPro:IPR008251, PMID:7667093]
synonym: "chromoshadow domain binding" EXACT [GOC:vk]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070088
name: PHA granule
namespace: cellular_component
def: "An inclusion body located in the cytoplasm that consists of polyhydroxyalkanoate (PHA) molecules and associated proteins, surrounded by a phospholipid monolayer; the proteins include PHA synthase, PHA depolymerase and 3HB-oligomer hydroxylase, phasins (PhaPs), which are thought to be the major structural proteins of the membrane surrounding the inclusion, and the regulator of phasin expression PhaR." [GOC:mah, PMID:15762612]
subset: gosubset_prok
synonym: "PHB granule" NARROW []
synonym: "polyhydroxyalkanoate granule" EXACT []
is_a: GO:0016234 ! inclusion body
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0070089
name: chloride-activated potassium channel activity
namespace: molecular_function
def: "Catalysis of the chloride concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:kmv, GOC:mtg_transport]
subset: gosubset_prok
is_a: GO:0005267 ! potassium channel activity
is_a: GO:0022839 ! ion gated channel activity

[Term]
id: GO:0070090
name: metaphase plate
namespace: cellular_component
def: "The intracellular plane, located halfway between the poles of the spindle, where chromosomes align during metaphase of mitotic or meiotic nuclear division." [GOC:mah]
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0070091
name: glucagon secretion
namespace: biological_process
def: "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans)." [GOC:BHF, GOC:rl]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0070092
name: regulation of glucagon secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah]
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: regulates GO:0070091 ! glucagon secretion

[Term]
id: GO:0070093
name: negative regulation of glucagon secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah]
synonym: "down regulation of glucagon secretion" EXACT []
synonym: "down-regulation of glucagon secretion" EXACT []
synonym: "downregulation of glucagon secretion" EXACT []
synonym: "inhibition of glucagon secretion" NARROW []
is_a: GO:0070092 ! regulation of glucagon secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion
relationship: negatively_regulates GO:0070091 ! glucagon secretion

[Term]
id: GO:0070094
name: positive regulation of glucagon secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah]
synonym: "activation of glucagon secretion" NARROW []
synonym: "stimulation of glucagon secretion" NARROW []
synonym: "up regulation of glucagon secretion" EXACT []
synonym: "up-regulation of glucagon secretion" EXACT []
synonym: "upregulation of glucagon secretion" EXACT []
is_a: GO:0070092 ! regulation of glucagon secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion
relationship: positively_regulates GO:0070091 ! glucagon secretion

[Term]
id: GO:0070095
name: fructose-6-phosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with fructose 6-phosphate." [GOC:mah]
synonym: "D-fructose 6-phosphate binding" NARROW []
synonym: "fructose 6-phosphate binding" EXACT []
is_a: GO:0070061 ! fructose binding

[Term]
id: GO:0070096
name: mitochondrial outer membrane translocase complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex." [GOC:BHF, GOC:vk]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0007008 ! outer mitochondrial membrane organization

[Term]
id: GO:0070097
name: delta-catenin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the delta subunit of the catenin complex." [GOC:rph]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0070098
name: chemokine-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah]
synonym: "chemokine-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0070099
name: regulation of chemokine-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah]
synonym: "regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0070100
name: negative regulation of chemokine-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah]
synonym: "negative regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway
relationship: negatively_regulates GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0070101
name: positive regulation of chemokine-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah]
synonym: "positive regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway
relationship: positively_regulates GO:0070098 ! chemokine-mediated signaling pathway

[Term]
id: GO:0070102
name: interleukin-6-mediated signaling pathway
namespace: biological_process
def: "A series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor." [GOC:add, GOC:BHF, GOC:mah]
synonym: "IL-6-mediated signaling pathway" RELATED []
synonym: "interleukin-6-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0070103
name: regulation of interleukin-6-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6-mediated binding to a cell surface receptor." [GOC:BHF, GOC:mah]
synonym: "regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah]
synonym: "regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0070102 ! interleukin-6-mediated signaling pathway

[Term]
id: GO:0070104
name: negative regulation of interleukin-6-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor." [GOC:BHF, GOC:mah]
synonym: "negative regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0070103 ! regulation of interleukin-6-mediated signaling pathway
relationship: negatively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway

[Term]
id: GO:0070105
name: positive regulation of interleukin-6-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor." [GOC:BHF, GOC:mah]
synonym: "positive regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0070103 ! regulation of interleukin-6-mediated signaling pathway
relationship: positively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway

[Term]
id: GO:0070106
name: interleukin-27-mediated signaling pathway
namespace: biological_process
def: "A series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor." [GOC:add, GOC:BHF, GOC:mah]
synonym: "IL-27-mediated signaling pathway" EXACT [GOC:mah]
synonym: "IL27RA/IL6ST signaling pathway" EXACT [GOC:add]
synonym: "interleukin-27-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0070107
name: regulation of interleukin-27-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27-mediated binding to a cell surface receptor." [GOC:BHF, GOC:mah]
synonym: "regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah]
synonym: "regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add]
synonym: "regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0070106 ! interleukin-27-mediated signaling pathway

[Term]
id: GO:0070108
name: negative regulation of interleukin-27-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor." [GOC:BHF, GOC:mah]
synonym: "negative regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add]
synonym: "negative regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0070107 ! regulation of interleukin-27-mediated signaling pathway
relationship: negatively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway

[Term]
id: GO:0070109
name: positive regulation of interleukin-27-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor." [GOC:BHF, GOC:mah]
synonym: "positive regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add]
synonym: "positive regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0070107 ! regulation of interleukin-27-mediated signaling pathway
relationship: positively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway

[Term]
id: GO:0070110
name: ciliary neurotrophic factor receptor complex
namespace: cellular_component
def: "A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR." [GOC:BHF, GOC:mah, GOC:rl, PMID:12707266]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0070111
name: organellar chromatophore
namespace: cellular_component
def: "A bacteroid-containing symbiosome in which the bacterial component is a genetically highly reduced cyanobacterium that is photosynthetically active and incapable of an independent existence outside its host. The chromatophore functions as a photosynthetic organelle, and has been found and characterized in the amoeba Paulinella chromatophora." [GOC:expert_mm, PMID:18356055]
synonym: "Paulinella-type chromatophore" EXACT []
is_a: GO:0043660 ! bacteroid-containing symbiosome

[Term]
id: GO:0070112
name: organellar chromatophore membrane
namespace: cellular_component
def: "Either of the lipid bilayers that surround an organellar chromatophore." [GOC:mah]
subset: gosubset_prok
synonym: "Paulinella-type chromatophore membrane" EXACT [GOC:mah]
is_a: GO:0030659 ! cytoplasmic vesicle membrane
relationship: part_of GO:0070111 ! organellar chromatophore

[Term]
id: GO:0070113
name: organellar chromatophore inner membrane
namespace: cellular_component
def: "The inner, i.e. lumen-facing, of the two lipid bilayers surrounding an organellar chromatophore." [GOC:mah]
synonym: "Paulinella-type chromatophore inner membrane" EXACT [GOC:mah]
is_a: GO:0070112 ! organellar chromatophore membrane

[Term]
id: GO:0070114
name: organellar chromatophore outer membrane
namespace: cellular_component
def: "The outer, i.e. cytoplasm-facing, of the two lipid bilayers surrounding an organellar chromatophore." [GOC:mah]
synonym: "Paulinella-type chromatophore outer membrane" EXACT [GOC:mah]
is_a: GO:0043661 ! peribacteroid membrane
is_a: GO:0070112 ! organellar chromatophore membrane

[Term]
id: GO:0070115
name: organellar chromatophore intermembrane space
namespace: cellular_component
def: "The region between the inner and outer lipid bilayers that surround an organellar chromatophore." [GOC:mah]
subset: gosubset_prok
synonym: "Paulinella-type chromatophore intermembrane space" EXACT [GOC:mah]
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0070111 ! organellar chromatophore

[Term]
id: GO:0070116
name: organellar chromatophore thylakoid
namespace: cellular_component
def: "A thylakoid located in an organellar chromatophore." [GOC:mah]
subset: gosubset_prok
synonym: "Paulinella-type chromatophore thylakoid" EXACT [GOC:mah]
is_a: GO:0009579 ! thylakoid
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0070111 ! organellar chromatophore

[Term]
id: GO:0070117
name: organellar chromatophore thylakoid lumen
namespace: cellular_component
def: "The volume enclosed by an organellar chromatophore thylakoid membrane." [GOC:mah]
synonym: "Paulinella-type chromatophore thylakoid lumen" EXACT [GOC:mah]
is_a: GO:0031977 ! thylakoid lumen
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0070116 ! organellar chromatophore thylakoid

[Term]
id: GO:0070118
name: organellar chromatophore thylakoid membrane
namespace: cellular_component
def: "The lipid bilayer membrane of any thylakoid within an organellar chromatophore." [GOC:mah]
synonym: "Paulinella-type chromatophore thylakoid membrane" EXACT [GOC:mah]
is_a: GO:0042651 ! thylakoid membrane
is_a: GO:0044433 ! cytoplasmic vesicle part
relationship: part_of GO:0070116 ! organellar chromatophore thylakoid

[Term]
id: GO:0070119
name: ciliary neurotrophic factor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the cytokine ciliary neurotrophic factor." [GOC:BHF, GOC:mah]
synonym: "CNTF binding" EXACT [GOC:mah]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0070120
name: ciliary neurotrophic factor-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of ciliary neurotrophic factor binding to a cell surface receptor." [GOC:BHF, GOC:mah]
synonym: "ciliary neurotrophic factor-mediated signalling pathway" EXACT [GOC:mah]
synonym: "CNTF-mediated signaling pathway" EXACT [GOC:rl]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0070121
name: Kupffer's vesicle development
namespace: biological_process
def: "The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period." [GOC:dgh]
synonym: "KV development" EXACT [GOC:dgh]
is_a: GO:0048856 ! anatomical structure development

[Term]
id: GO:0070122
name: isopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an isopeptide bond. An isopeptide bond is an amide linkage between a carboxyl group of one amino acid and an amino group of another amino acid in which at least one of these groups is not on the a-carbon of one of the amino acids (for example, the link between an epsilon-amino group of a lysine molecule to a carboxyl group on a second amino acid is an isopeptide bond)." [GOC:mah, http:128.240.24.212/cgi-bin/omd?isopeptide+bond]
is_a: GO:0008233 ! peptidase activity

[Term]
id: GO:0070123
name: transforming growth factor beta receptor activity, type III
namespace: molecular_function
def: "Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors." [GOC:BHF, GOC:mah, PMID:9759503]
synonym: "betaglycan" NARROW []
synonym: "endoglin" NARROW []
synonym: "transforming growth factor beta ligand binding to type III receptor" RELATED []
synonym: "type III TGF-beta receptor activity" EXACT []
synonym: "type III TGFbeta receptor activity" EXACT []
synonym: "type III transforming growth factor beta receptor activity" EXACT []
is_a: GO:0005024 ! transforming growth factor beta receptor activity

[Term]
id: GO:0070124
name: mitochondrial translational initiation
namespace: biological_process
def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:mah]
synonym: "mitochondrial translation initiation" EXACT [GOC:mah]
is_a: GO:0006413 ! translational initiation
relationship: part_of GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070125
name: mitochondrial translational elongation
namespace: biological_process
def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." [GOC:mah]
synonym: "mitochondrial translation elongation" EXACT [GOC:mah]
is_a: GO:0006414 ! translational elongation
relationship: part_of GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070126
name: mitochondrial translational termination
namespace: biological_process
def: "The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa)." [GOC:mah, http:mitogenome.org/index.php/Genetic_Code_of_mitochondria]
synonym: "mitochondrial translation termination" EXACT [GOC:mah]
is_a: GO:0006415 ! translational termination
relationship: part_of GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070127
name: tRNA aminoacylation for mitochondrial protein translation
namespace: biological_process
def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion." [GOC:mah]
is_a: GO:0006418 ! tRNA aminoacylation for protein translation
relationship: part_of GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070129
name: regulation of mitochondrial translation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]
synonym: "regulation of mitochondrial protein anabolism" EXACT [GOC:mah]
synonym: "regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah]
synonym: "regulation of mitochondrial protein formation" EXACT [GOC:mah]
synonym: "regulation of mitochondrial protein synthesis" EXACT [GOC:mah]
is_a: GO:0006417 ! regulation of translation
is_a: GO:0010821 ! regulation of mitochondrion organization
relationship: regulates GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070130
name: negative regulation of mitochondrial translation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]
synonym: "negative regulation of mitochondrial protein anabolism" EXACT [GOC:mah]
synonym: "negative regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of mitochondrial protein formation" EXACT [GOC:mah]
synonym: "negative regulation of mitochondrial protein synthesis" EXACT [GOC:mah]
is_a: GO:0010823 ! negative regulation of mitochondrion organization
is_a: GO:0017148 ! negative regulation of translation
is_a: GO:0070129 ! regulation of mitochondrial translation
relationship: negatively_regulates GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070131
name: positive regulation of mitochondrial translation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah]
synonym: "positive regulation of mitochondrial protein anabolism" EXACT [GOC:mah]
synonym: "positive regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of mitochondrial protein formation" EXACT [GOC:mah]
synonym: "positive regulation of mitochondrial protein synthesis" EXACT [GOC:mah]
is_a: GO:0010822 ! positive regulation of mitochondrion organization
is_a: GO:0045727 ! positive regulation of translation
is_a: GO:0070129 ! regulation of mitochondrial translation
relationship: positively_regulates GO:0032543 ! mitochondrial translation

[Term]
id: GO:0070132
name: regulation of mitochondrial translational initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah]
synonym: "regulation of mitochondrial translation initiation" EXACT [GOC:mah]
is_a: GO:0006446 ! regulation of translational initiation
is_a: GO:0070129 ! regulation of mitochondrial translation
relationship: regulates GO:0070124 ! mitochondrial translational initiation

[Term]
id: GO:0070133
name: negative regulation of mitochondrial translational initiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah]
synonym: "negative regulation of mitochondrial translation initiation" EXACT [GOC:mah]
is_a: GO:0045947 ! negative regulation of translational initiation
is_a: GO:0070132 ! regulation of mitochondrial translational initiation
relationship: negatively_regulates GO:0070124 ! mitochondrial translational initiation

[Term]
id: GO:0070134
name: positive regulation of mitochondrial translational initiation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah]
synonym: "positive regulation of mitochondrial translation initiation" EXACT [GOC:mah]
is_a: GO:0045948 ! positive regulation of translational initiation
is_a: GO:0070132 ! regulation of mitochondrial translational initiation
relationship: positively_regulates GO:0070124 ! mitochondrial translational initiation

[Term]
id: GO:0070135
name: beta-1,2-oligomannoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan." [GOC:mah, PMID:18234669]
synonym: "beta-1,2-oligomannoside metabolism" EXACT [GOC:mah]
is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process
is_a: GO:0010383 ! cell wall polysaccharide metabolic process
is_a: GO:0044264 ! cellular polysaccharide metabolic process

[Term]
id: GO:0070136
name: beta-1,2-oligomannoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan." [GOC:mah, PMID:18234669]
synonym: "beta-1,2-oligomannoside anabolism" EXACT [GOC:mah]
synonym: "beta-1,2-oligomannoside biosynthesis" EXACT [GOC:mah]
synonym: "beta-1,2-oligomannoside formation" EXACT [GOC:mah]
synonym: "beta-1,2-oligomannoside synthesis" EXACT [GOC:mah]
is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process
is_a: GO:0070135 ! beta-1,2-oligomannoside metabolic process

[Term]
id: GO:0070137
name: small conjugating protein-specific endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO)." [GOC:mah]
is_a: GO:0004197 ! cysteine-type endopeptidase activity
is_a: GO:0019783 ! small conjugating protein-specific protease activity

[Term]
id: GO:0070138
name: small conjugating protein-specific isopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an isopeptide bond between a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO) and a protein to which the small protein has been conjugated." [GOC:mah]
is_a: GO:0019783 ! small conjugating protein-specific protease activity
is_a: GO:0070122 ! isopeptidase activity

[Term]
id: GO:0070139
name: SUMO-specific endopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO." [GOC:mah]
is_a: GO:0016929 ! SUMO-specific protease activity
is_a: GO:0070137 ! small conjugating protein-specific endopeptidase activity

[Term]
id: GO:0070140
name: SUMO-specific isopeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of an isopeptide bond between the small conjugating protein SUMO and a protein to which SUMO has been conjugated." [GOC:mah]
is_a: GO:0016929 ! SUMO-specific protease activity
is_a: GO:0070138 ! small conjugating protein-specific isopeptidase activity

[Term]
id: GO:0070141
name: response to UV-A
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 400 to 500 nm." [GOC:BHF, GOC:mah]
synonym: "response to UV-A light stimulus" EXACT []
synonym: "response to UV-A radiation stimulus" EXACT []
synonym: "response to UVA light stimulus" EXACT []
synonym: "response to UVA radiation stimulus" EXACT []
is_a: GO:0009411 ! response to UV

[Term]
id: GO:0070142
name: synaptic vesicle budding
namespace: biological_process
def: "Evagination of a membrane to form a synaptic vesicle." [GOC:mah]
is_a: GO:0006900 ! membrane budding
relationship: part_of GO:0048489 ! synaptic vesicle transport

[Term]
id: GO:0070143
name: mitochondrial alanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling alanine to alanyl-tRNA in a mitochondrion, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006419 ! alanyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070144
name: mitochondrial arginyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling arginine to arginyl-tRNA in a mitochondrion, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006420 ! arginyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070145
name: mitochondrial asparaginyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling asparagine to asparaginyl-tRNA in a mitochondrion, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006421 ! asparaginyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070146
name: mitochondrial aspartyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling aspartate to aspartyl-tRNA in a mitochondrion, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006422 ! aspartyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070147
name: mitochondrial cysteinyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006423 ! cysteinyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070148
name: mitochondrial glutaminyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glutamine to glutaminyl-tRNA in a mitochondrion, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006425 ! glutaminyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070149
name: mitochondrial glutamyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glutamate to glutamyl-tRNA in a mitochondrion, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006424 ! glutamyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070150
name: mitochondrial glycyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006426 ! glycyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070151
name: mitochondrial histidyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling histidine to histidyl-tRNA in a mitochondrion, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006427 ! histidyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070152
name: mitochondrial isoleucyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling isoleucine to isoleucyl-tRNA in a mitochondrion, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006428 ! isoleucyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070153
name: mitochondrial leucyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling leucine to leucyl-tRNA in a mitochondrion, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006429 ! leucyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070154
name: mitochondrial lysyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling lysine to lysyl-tRNA in a mitochondrion, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006430 ! lysyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070155
name: mitochondrial methionyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling methionine to methionyl-tRNA in a mitochondrion, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006431 ! methionyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070156
name: mitochondrial phenylalanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling phenylalanine to phenylalanyl-tRNA in a mitochondrion, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006432 ! phenylalanyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070157
name: mitochondrial prolyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling proline to prolyl-tRNA in a mitochondrion, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006433 ! prolyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070158
name: mitochondrial seryl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006434 ! seryl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070159
name: mitochondrial threonyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling threonine to threonyl-tRNA in a mitochondrion, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006435 ! threonyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070160
name: occluding junction
namespace: cellular_component
def: "A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [ISBN:0815332181]
synonym: "occluding cell junction" EXACT [GOC:mah]
is_a: GO:0005911 ! cell-cell junction

[Term]
id: GO:0070161
name: anchoring junction
namespace: cellular_component
def: "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181]
synonym: "anchoring cell junction" EXACT [GOC:mah]
is_a: GO:0030054 ! cell junction

[Term]
id: GO:0070162
name: adiponectin secretion
namespace: biological_process
def: "The regulated release of adiponectin, a protein hormone, by adipose tissue." [GOC:BHF, GOC:rl]
is_a: GO:0060986 ! endocrine hormone secretion

[Term]
id: GO:0070163
name: regulation of adiponectin secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of adiponectin from a cell or group of cells." [GOC:mah]
is_a: GO:0044060 ! regulation of endocrine process
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0070162 ! adiponectin secretion

[Term]
id: GO:0070164
name: negative regulation of adiponectin secretion
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of adiponectin from a cell or group of cells." [GOC:BHF, GOC:mah]
synonym: "down regulation of adiponectin secretion" EXACT [GOC:mah]
synonym: "down-regulation of adiponectin secretion" EXACT [GOC:mah]
synonym: "downregulation of adiponectin secretion" EXACT [GOC:mah]
synonym: "inhibition of adiponectin secretion" NARROW [GOC:mah]
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0070163 ! regulation of adiponectin secretion
relationship: negatively_regulates GO:0070162 ! adiponectin secretion

[Term]
id: GO:0070165
name: positive regulation of adiponectin secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell or group of cells." [GOC:BHF, GOC:mah]
synonym: "activation of adiponectin secretion" NARROW [GOC:mah]
synonym: "stimulation of adiponectin secretion" NARROW [GOC:mah]
synonym: "up regulation of adiponectin secretion" EXACT [GOC:mah]
synonym: "up-regulation of adiponectin secretion" EXACT [GOC:mah]
synonym: "upregulation of adiponectin secretion" EXACT [GOC:mah]
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0070163 ! regulation of adiponectin secretion
relationship: positively_regulates GO:0070162 ! adiponectin secretion

[Term]
id: GO:0070166
name: enamel mineralization
namespace: biological_process
def: "The process by which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel." [GOC:BHF, GOC:mah, PMID:16931858]
synonym: "enamel formation" RELATED [PMID:16931858]
is_a: GO:0034505 ! tooth mineralization

[Term]
id: GO:0070167
name: regulation of biomineral formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of biomineral formation, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah]
synonym: "regulation of biomineralization" EXACT [GOC:mah]
synonym: "regulation of mineralization" EXACT [GOC:mah]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0031214 ! biomineral formation

[Term]
id: GO:0070168
name: negative regulation of biomineral formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of biomineral formation, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah]
synonym: "negative regulation of biomineralization" EXACT [GOC:mah]
synonym: "negative regulation of mineralization" EXACT [GOC:mah]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0070167 ! regulation of biomineral formation
relationship: negatively_regulates GO:0031214 ! biomineral formation

[Term]
id: GO:0070169
name: positive regulation of biomineral formation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of biomineral formation, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah]
synonym: "positive regulation of biomineralization" EXACT [GOC:mah]
synonym: "positive regulation of mineralization" EXACT [GOC:mah]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0070167 ! regulation of biomineral formation
relationship: positively_regulates GO:0031214 ! biomineral formation

[Term]
id: GO:0070170
name: regulation of tooth mineralization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah]
is_a: GO:0042481 ! regulation of odontogenesis
is_a: GO:0070167 ! regulation of biomineral formation
relationship: regulates GO:0034505 ! tooth mineralization

[Term]
id: GO:0070171
name: negative regulation of tooth mineralization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah]
is_a: GO:0070168 ! negative regulation of biomineral formation
is_a: GO:0070170 ! regulation of tooth mineralization
relationship: negatively_regulates GO:0034505 ! tooth mineralization

[Term]
id: GO:0070172
name: positive regulation of tooth mineralization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah]
is_a: GO:0070169 ! positive regulation of biomineral formation
is_a: GO:0070170 ! regulation of tooth mineralization
relationship: positively_regulates GO:0034505 ! tooth mineralization

[Term]
id: GO:0070173
name: regulation of enamel mineralization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah]
is_a: GO:0070170 ! regulation of tooth mineralization
relationship: regulates GO:0070166 ! enamel mineralization

[Term]
id: GO:0070174
name: negative regulation of enamel mineralization
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah]
is_a: GO:0070171 ! negative regulation of tooth mineralization
is_a: GO:0070173 ! regulation of enamel mineralization
relationship: negatively_regulates GO:0070166 ! enamel mineralization

[Term]
id: GO:0070175
name: positive regulation of enamel mineralization
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah]
is_a: GO:0070172 ! positive regulation of tooth mineralization
is_a: GO:0070173 ! regulation of enamel mineralization
relationship: positively_regulates GO:0070166 ! enamel mineralization

[Term]
id: GO:0070176
name: DRM complex
namespace: cellular_component
def: "A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification." [PMID:17075059]
synonym: "DP/Rb/MuvB" EXACT [PMID:17075059]
is_a: GO:0017053 ! transcriptional repressor complex

[Term]
id: GO:0070177
name: contractile vacuole discharge
namespace: biological_process
def: "The regulated release of water from a contractile vacuole to the outside of a cell by fusion of the contractile vacuole membrane with the plasma membrane." [GOC:mah, PMID:10369671]
is_a: GO:0016192 ! vesicle-mediated transport
is_a: GO:0032940 ! secretion by cell

[Term]
id: GO:0070178
name: D-serine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid." [ChEBI:16523, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-serine metabolism" EXACT []
is_a: GO:0009069 ! serine family amino acid metabolic process

[Term]
id: GO:0070179
name: D-serine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine." [ChEBI:16523, GOC:jsg, GOC:mah]
subset: gosubset_prok
synonym: "D-serine anabolism" EXACT []
synonym: "D-serine biosynthesis" EXACT []
synonym: "D-serine formation" EXACT []
synonym: "D-serine synthesis" EXACT []
is_a: GO:0009070 ! serine family amino acid biosynthetic process
is_a: GO:0046437 ! D-amino acid biosynthetic process
is_a: GO:0070178 ! D-serine metabolic process

[Term]
id: GO:0070180
name: LSU rRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh]
synonym: "25S rRNA binding" EXACT [GOC:elh]
is_a: GO:0019843 ! rRNA binding

[Term]
id: GO:0070181
name: SSU rRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the small ribosomal subunit RNA (SSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 18S rRNA." [GOC:elh]
synonym: "18S rRNA binding" EXACT [GOC:elh]
is_a: GO:0019843 ! rRNA binding

[Term]
id: GO:0070182
name: DNA polymerase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a DNA polymerase." [GOC:BHF, GOC:mah]
subset: gosubset_prok
is_a: GO:0019899 ! enzyme binding

[Term]
id: GO:0070183
name: mitochondrial tryptophanyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006436 ! tryptophanyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070184
name: mitochondrial tyrosyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling threonine to tyrosyl-tRNA in a mitochondrion, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006437 ! tyrosyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070185
name: mitochondrial valyl-tRNA aminoacylation
namespace: biological_process
def: "The process of coupling valine to valyl-tRNA in a mitochondrion, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc]
is_a: GO:0006438 ! valyl-tRNA aminoacylation
is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation

[Term]
id: GO:0070186
name: growth hormone activity
namespace: molecular_function
def: "The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth." [GOC:BHF, GOC:mah, PMID:11445442]
synonym: "GH activity" EXACT [PMID:11445442]
synonym: "pituitary growth hormone activity" NARROW [GOC:vk]
synonym: "placental growth hormone activity" NARROW [GOC:vk]
is_a: GO:0005179 ! hormone activity

[Term]
id: GO:0070187
name: telosome
namespace: cellular_component
def: "A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex contains TRF1, TRF2, POT1, RAP1, TIN2 and TPP1 in mammalian cells, and Pot1, Tpz1, Ccq1, Poz1, and Rap1 in Schizosaccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1." [GOC:expert_mf, GOC:mah, GOC:vw, PMID:18828880]
synonym: "Pot1 complex" EXACT [GOC:vw]
synonym: "Pot1-Tpz1 complex" EXACT [GOC:vw]
synonym: "shelterin complex" EXACT [GOC:mah, GOC:vw]
is_a: GO:0000783 ! nuclear telomere cap complex

[Term]
id: GO:0070188
name: Stn1-Ten1 complex
namespace: cellular_component
def: "A nuclear telomere cap complex that is formed by the association of the Stn1 and Ten1 proteins with telomeric DNA; in some species a third protein is present." [GOC:mah, GOC:vw, PMID:17715303, PMID:19064932]
is_a: GO:0000783 ! nuclear telomere cap complex

[Term]
id: GO:0070189
name: kynurenine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [ChEBI:28683, GOC:mah, GOC:rph]
synonym: "kynurenine metabolism" EXACT []
is_a: GO:0006520 ! cellular amino acid metabolic process
is_a: GO:0006575 ! cellular amino acid derivative metabolic process

[Term]
id: GO:0070190
name: inositol hexakisphosphate 1-kinase or 3-kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate or ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate." [GOC:jp, PMID:18981179]
is_a: GO:0000828 ! inositol hexakisphosphate kinase activity

[Term]
id: GO:0070191
name: methionine-R-sulfoxide reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on free oxidized methionine with specificity for the R enantiomer; does not act on oxidized methionine in peptide linkage. Thioredoxin disulfide is the oxidized form of thioredoxin." [GOC:mcc, PMID:17535911, PMID:19049972]
xref: EC:1.8.4.-
is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor

[Term]
id: GO:0070192
name: chromosome organization involved in meiosis
namespace: biological_process
def: "A process of chromosome organization that is involved in meiosis." [GOC:mah]
synonym: "meiotic chromosome organization" EXACT [GOC:mah]
is_a: GO:0022402 ! cell cycle process
is_a: GO:0051276 ! chromosome organization
relationship: part_of GO:0007126 ! meiosis

[Term]
id: GO:0070193
name: synaptonemal complex organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis." [GOC:mah]
is_a: GO:0051276 ! chromosome organization

[Term]
id: GO:0070194
name: synaptonemal complex disassembly
namespace: biological_process
def: "The controlled breakdown of a synaptonemal complex." [GOC:mah]
is_a: GO:0022411 ! cellular component disassembly
is_a: GO:0070193 ! synaptonemal complex organization

[Term]
id: GO:0070195
name: growth hormone receptor complex
namespace: cellular_component
def: "A receptor complex that consists of two identical subunits and binds growth hormone." [GOC:BHF, GOC:mah, GOC:vk, PMID:11445442]
is_a: GO:0043235 ! receptor complex

[Term]
id: GO:0070196
name: eukaryotic translation initiation factor 3 complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 3 complex." [GOC:mah]
synonym: "eIF-3 assembly" EXACT [GOC:mah]
synonym: "eIF3 assembly" EXACT [GOC:mah]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0070197
name: attachment of telomeres to nuclear envelope
namespace: biological_process
def: "The cell cycle process whereby physical connections are formed between telomeres and the nuclear envelope, facilitating bouquet formation." [GOC:jp, PMID:18818742]
is_a: GO:0022402 ! cell cycle process
relationship: part_of GO:0045141 ! meiotic telomere clustering

[Term]
id: GO:0070198
name: protein localization to chromosome, telomeric region
namespace: biological_process
def: "Any process by which a protein is transported to, or maintained at, the telomeric region of a chromosome." [GOC:BHF, GOC:mah]
synonym: "protein localization to telomere" EXACT [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome

[Term]
id: GO:0070199
name: establishment of protein localization to chromosome
namespace: biological_process
def: "The directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah]
is_a: GO:0045184 ! establishment of protein localization
relationship: part_of GO:0034502 ! protein localization to chromosome

[Term]
id: GO:0070200
name: establishment of protein localization to telomere
namespace: biological_process
def: "The directed movement of a protein to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:mah]
synonym: "establishment of protein localization to chromosome, telomeric region" EXACT [GOC:mah]
is_a: GO:0070199 ! establishment of protein localization to chromosome
relationship: part_of GO:0070198 ! protein localization to chromosome, telomeric region

[Term]
id: GO:0070201
name: regulation of establishment of protein localization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah]
is_a: GO:0032880 ! regulation of protein localization
relationship: regulates GO:0045184 ! establishment of protein localization

[Term]
id: GO:0070202
name: regulation of establishment of protein localization to chromosome
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah]
is_a: GO:0060341 ! regulation of cellular localization
is_a: GO:0070201 ! regulation of establishment of protein localization
relationship: regulates GO:0070199 ! establishment of protein localization to chromosome

[Term]
id: GO:0070203
name: regulation of establishment of protein localization to telomere
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:mah]
is_a: GO:0070202 ! regulation of establishment of protein localization to chromosome
relationship: regulates GO:0070200 ! establishment of protein localization to telomere

[Term]
id: GO:0070204
name: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate + CO2." [EC:2.2.1.9, MetaCyc:2.5.1.64-RXN]
comment: Note that this function was formerly EC:4.1.3.18.
subset: gosubset_prok
synonym: "MenD" RELATED [EC:2.2.1.9]
synonym: "SEPHCHC synthase activity" EXACT [EC:2.2.1.9]
xref: EC:2.2.1.9
xref: MetaCyc:2.5.1.64-RXN
is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups

[Term]
id: GO:0070205
name: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate." [EC:4.2.99.20, MetaCyc:RXN-9310]
synonym: " 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase activity" EXACT [EC:4.2.99.20]
synonym: "6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase activity" EXACT [EC:4.2.99.20]
synonym: "MenH" RELATED [EC:4.2.99.20]
synonym: "SHCHC synthase activity" EXACT [EC:4.2.99.20]
synonym: "YfbB" RELATED [EC:4.2.99.20]
xref: EC:4.2.99.20
xref: MetaCyc:RXN-9310
is_a: GO:0016835 ! carbon-oxygen lyase activity

[Term]
id: GO:0070206
name: protein trimerization
namespace: biological_process
def: "The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits." [GOC:hjd]
subset: gosubset_prok
synonym: "protein trimer assembly" EXACT [GOC:hjd]
synonym: "protein trimer biosynthesis" EXACT [GOC:hjd]
synonym: "protein trimer biosynthetic process" EXACT [GOC:hjd]
synonym: "protein trimer formation" EXACT [GOC:hjd]
is_a: GO:0051259 ! protein oligomerization

[Term]
id: GO:0070207
name: protein homotrimerization
namespace: biological_process
def: "The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits." [GOC:hjd]
subset: gosubset_prok
synonym: "protein homotrimer assembly" EXACT [GOC:hjd]
synonym: "protein homotrimer biosynthesis" EXACT [GOC:hjd]
synonym: "protein homotrimer biosynthetic process" EXACT [GOC:hjd]
synonym: "protein homotrimer formation" EXACT [GOC:hjd]
is_a: GO:0051260 ! protein homooligomerization
is_a: GO:0070206 ! protein trimerization

[Term]
id: GO:0070208
name: protein heterotrimerization
namespace: biological_process
def: "The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical." [GOC:hjd]
subset: gosubset_prok
synonym: "protein heterotrimer assembly" EXACT [GOC:hjd]
synonym: "protein heterotrimer biosynthesis" EXACT [GOC:hjd]
synonym: "protein heterotrimer biosynthetic process" EXACT [GOC:hjd]
synonym: "protein heterotrimer formation" EXACT [GOC:hjd]
is_a: GO:0051291 ! protein heterooligomerization
is_a: GO:0070206 ! protein trimerization

[Term]
id: GO:0070209
name: ASTRA complex
namespace: cellular_component
def: "A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p." [GOC:rb, PMID:19040720]
is_a: GO:0000790 ! nuclear chromatin
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0070210
name: Rpd3L-Expanded complex
namespace: cellular_component
def: "A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins." [GOC:rb, PMID:19040720]
synonym: "Clr6-LE complex" EXACT [GOC:vw]
is_a: GO:0000118 ! histone deacetylase complex
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0070211
name: Snt2C complex
namespace: cellular_component
def: "A histone deacetylase complex that is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains Snt2p, Ecm5p and Rpd3p." [GOC:rb, PMID:19040720]
is_a: GO:0000118 ! histone deacetylase complex
is_a: GO:0000790 ! nuclear chromatin

[Term]
id: GO:0070212
name: protein amino acid poly-ADP-ribosylation
namespace: biological_process
def: "The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain." [GOC:BHF, GOC:mah, GOC:rl]
synonym: "addition of poly-ADP-ribose to protein" EXACT [GOC:rl]
synonym: "poly(ADP-ribose) addition to protein" EXACT [GOC:rl]
synonym: "protein poly(ADP-ribose) metabolism" RELATED [GOC:rl]
synonym: "protein poly(ADP-ribose) synthesis" EXACT [GOC:rl]
is_a: GO:0006471 ! protein amino acid ADP-ribosylation

[Term]
id: GO:0070213
name: protein amino acid auto-ADP-ribosylation
namespace: biological_process
def: "The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [GOC:BHF, GOC:rl]
is_a: GO:0006471 ! protein amino acid ADP-ribosylation

[Term]
id: GO:0070214
name: CSK-GAP-A.p62 complex
namespace: cellular_component
def: "A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation." [PMID:7544435]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part
relationship: part_of GO:0031252 ! cell leading edge

[Term]
id: GO:0070215
name: MDM2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any isoform of the MDM2 protein, a negative regulator of p53." [GOC:mah, GOC:nln]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0070216
name: MDM4 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any isoform of the MDM4 protein, a negative regulator of p53." [GOC:mah, GOC:nln]
synonym: "MDMX binding" EXACT [GOC:nln]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0070217
name: transcription factor TFIIIB complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a transcription factor TFIIIB complex." [GOC:mah]
synonym: "TFIIIB assembly" EXACT [GOC:mah]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0070218
name: sulfide ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of sulfide ions within an organism or cell." [GOC:mah]
synonym: "sulfide generation" RELATED [GOC:mah]
synonym: "sulfide homeostasis" EXACT [GOC:mah]
synonym: "sulfide production" RELATED [GOC:mah]
synonym: "sulphide generation" RELATED [GOC:mah]
synonym: "sulphide homeostasis" EXACT [GOC:mah]
synonym: "sulphide ion homeostasis" EXACT [GOC:mah]
synonym: "sulphide production" RELATED [GOC:mah]
is_a: GO:0055083 ! monovalent inorganic anion homeostasis

[Term]
id: GO:0070219
name: cellular sulfide ion homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of sulfide ions at the level of a cell." [GOC:mah]
synonym: "cellular sulfide homeostasis" EXACT [GOC:mah]
synonym: "cellular sulphide homeostasis" EXACT [GOC:mah]
synonym: "cellular sulphide ion homeostasis" EXACT [GOC:mah]
is_a: GO:0030320 ! cellular monovalent inorganic anion homeostasis
is_a: GO:0070218 ! sulfide ion homeostasis

[Term]
id: GO:0070220
name: aerobic sulfur oxidation
namespace: biological_process
def: "A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase, and requires the presence of oxygen." [MetaCyc:SULFUROX-PWY]
subset: gosubset_prok
synonym: "aerobic sulphur oxidation" EXACT [GOC:mah]
xref: MetaCyc:SULFUROX-PWY
is_a: GO:0019417 ! sulfur oxidation

[Term]
id: GO:0070221
name: sulfide oxidation, using sulfide:quinone oxidoreductase
namespace: biological_process
def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide:quinone oxidoreductase." [MetaCyc:P222-PWY]
subset: gosubset_prok
synonym: "sulfide oxidation, using sulfide-quinone reductase" EXACT [GOC:mah, MetaCyc:P222-PWY]
synonym: "sulphide oxidation, using sulfide:quinone oxidoreductase" EXACT [GOC:mah]
xref: MetaCyc:P222-PWY
is_a: GO:0019418 ! sulfide oxidation

[Term]
id: GO:0070222
name: sulfide oxidation, using sulfide dehydrogenase
namespace: biological_process
def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide dehydrogenase." [MetaCyc:PWY-5274]
subset: gosubset_prok
synonym: "sulphide oxidation, using sulfide dehydrogenase" EXACT [GOC:mah]
xref: MetaCyc:PWY-5274
is_a: GO:0019418 ! sulfide oxidation

[Term]
id: GO:0070223
name: sulfide oxidation, using sulfur dioxygenase
namespace: biological_process
def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase." [MetaCyc:PWY-5285]
subset: gosubset_prok
synonym: "sulphide oxidation, using sulfur dioxygenase" EXACT [GOC:mah]
xref: MetaCyc:PWY-5285
is_a: GO:0019418 ! sulfide oxidation

[Term]
id: GO:0070224
name: sulfide:quinone oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen sulfide + a quinone = S0 + a hydroquinone." [MetaCyc:R17-RXN]
subset: gosubset_prok
synonym: "sulfide-quinone reductase activity" EXACT [MetaCyc:MONOMER-12314]
synonym: "sulphide:quinone oxidoreductase activity" EXACT [GOC:mah]
xref: EC:1.8.5.-
xref: MetaCyc:R17-RXN
is_a: GO:0016672 ! oxidoreductase activity, acting on sulfur group of donors, quinone or similar compound as acceptor

[Term]
id: GO:0070225
name: sulfide dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hydrogen sulfide + oxidized cytochrome c = S0 + reduced cytochrome c." [MetaCyc:RXN-8156]
subset: gosubset_prok
synonym: "flavocytochrome c sulfide dehydrogenase activity" EXACT [MetaCyc:RXN-8156]
synonym: "sulphide dehydrogenase activity" EXACT [GOC:mah]
xref: EC:1.8.2.-
xref: MetaCyc:RXN-8156
is_a: GO:0016669 ! oxidoreductase activity, acting on sulfur group of donors, cytochrome as acceptor

[Term]
id: GO:0070226
name: sulfur:ferric ion oxidoreductase activity
namespace: molecular_function
def: "Catalysis of the reaction: a perthiol + 4 Fe3+ + 3 H2O <=> sulfite + a thiol + 4 Fe2+ + 8 H+." [MetaCyc:SULFFEOXIDO-RXN]
subset: gosubset_prok
synonym: "hydrogen sulfide:ferric ion oxidoreductase" EXACT [MetaCyc:SULFFEOXIDO-RXN]
xref: MetaCyc:SULFFEOXIDO-RXN
is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors

[Term]
id: GO:0070227
name: lymphocyte apoptosis
namespace: biological_process
def: "The process of apoptosis in a lymphocyte." [GOC:add, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
is_a: GO:0006915 ! apoptosis

[Term]
id: GO:0070228
name: regulation of lymphocyte apoptosis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of lymphocyte death by apoptosis." [GOC:add, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
is_a: GO:0042981 ! regulation of apoptosis
relationship: regulates GO:0070227 ! lymphocyte apoptosis

[Term]
id: GO:0070229
name: negative regulation of lymphocyte apoptosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte death by apoptosis." [GOC:add, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "down regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "down-regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "downregulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "inhibition of lymphocyte apoptosis" NARROW [GOC:add]
is_a: GO:0043066 ! negative regulation of apoptosis
is_a: GO:0070228 ! regulation of lymphocyte apoptosis
relationship: negatively_regulates GO:0070227 ! lymphocyte apoptosis

[Term]
id: GO:0070230
name: positive regulation of lymphocyte apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptosis." [GOC:add, ISBN:0781765196]
comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542).
synonym: "activation of lymphocyte apoptosis" NARROW [GOC:add]
synonym: "stimulation of lymphocyte apoptosis" NARROW [GOC:add]
synonym: "up regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "up-regulation of lymphocyte apoptosis" EXACT [GOC:add]
synonym: "upregulation of lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0043065 ! positive regulation of apoptosis
is_a: GO:0070228 ! regulation of lymphocyte apoptosis
relationship: positively_regulates GO:0070227 ! lymphocyte apoptosis

[Term]
id: GO:0070231
name: T cell apoptosis
namespace: biological_process
def: "The process of apoptosis in a T cell." [GOC:add, ISBN:0781765196]
synonym: "programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "T-cell apoptosis" EXACT [GOC:add]
synonym: "T-lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070227 ! lymphocyte apoptosis

[Term]
id: GO:0070232
name: regulation of T cell apoptosis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of T cell death by apoptosis." [GOC:add, ISBN:0781765196]
synonym: "regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "regulation of T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "regulation of T-cell apoptosis" EXACT [GOC:add]
synonym: "regulation of T-lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070228 ! regulation of lymphocyte apoptosis
relationship: regulates GO:0070231 ! T cell apoptosis

[Term]
id: GO:0070233
name: negative regulation of T cell apoptosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell death by apoptosis." [GOC:add, ISBN:0781765196]
synonym: "down regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "down-regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "downregulation of T cell apoptosis" EXACT [GOC:add]
synonym: "inhibition of T cell apoptosis" NARROW [GOC:add]
synonym: "negative regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "negative regulation of T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "negative regulation of T-cell apoptosis" EXACT [GOC:add]
synonym: "negative regulation of T-lymphocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070229 ! negative regulation of lymphocyte apoptosis
is_a: GO:0070232 ! regulation of T cell apoptosis
relationship: negatively_regulates GO:0070231 ! T cell apoptosis

[Term]
id: GO:0070234
name: positive regulation of T cell apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of T cell death by apoptosis." [GOC:add, ISBN:0781765196]
synonym: "activation of T cell apoptosis" NARROW [GOC:add]
synonym: "positive regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add]
synonym: "positive regulation of T lymphocyte apoptosis" EXACT [GOC:add]
synonym: "positive regulation of T-cell apoptosis" EXACT [GOC:add]
synonym: "positive regulation of T-lymphocyte apoptosis" EXACT [GOC:add]
synonym: "stimulation of T cell apoptosis" NARROW [GOC:add]
synonym: "up regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "up-regulation of T cell apoptosis" EXACT [GOC:add]
synonym: "upregulation of T cell apoptosis" EXACT [GOC:add]
is_a: GO:0070230 ! positive regulation of lymphocyte apoptosis
is_a: GO:0070232 ! regulation of T cell apoptosis
relationship: positively_regulates GO:0070231 ! T cell apoptosis

[Term]
id: GO:0070235
name: regulation of activation-induced cell death of T cells
namespace: biological_process
def: "Any process that modulates the occurrence or rate of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196]
synonym: "regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add]
synonym: "regulation of activation-induced cell death of T-cells" EXACT [GOC:add]
synonym: "regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add]
synonym: "regulation of AICD" BROAD [GOC:add]
synonym: "regulation of antigen-driven apoptosis" BROAD [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0070232 ! regulation of T cell apoptosis
relationship: regulates GO:0006924 ! activation-induced cell death of T cells

[Term]
id: GO:0070236
name: negative regulation of activation-induced cell death of T cells
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196]
synonym: "down regulation of activation-induced cell death of T cells" EXACT [GOC:add]
synonym: "down-regulation of activation-induced cell death of T cells" EXACT [GOC:add]
synonym: "downregulation of activation-induced cell death of T cells" EXACT [GOC:add]
synonym: "inhibition of activation-induced cell death of T cells" NARROW [GOC:add]
synonym: "negative regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "negative regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add]
synonym: "negative regulation of activation-induced cell death of T-cells" EXACT [GOC:add]
synonym: "negative regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add]
synonym: "negative regulation of AICD" BROAD [GOC:add]
synonym: "negative regulation of antigen-driven apoptosis" BROAD []
is_a: GO:0070233 ! negative regulation of T cell apoptosis
is_a: GO:0070235 ! regulation of activation-induced cell death of T cells
relationship: negatively_regulates GO:0006924 ! activation-induced cell death of T cells

[Term]
id: GO:0070237
name: positive regulation of activation-induced cell death of T cells
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196]
synonym: "activation of activation-induced cell death of T cells" NARROW [GOC:add]
synonym: "positive regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "positive regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add]
synonym: "positive regulation of activation-induced cell death of T-cells" EXACT [GOC:add]
synonym: "positive regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add]
synonym: "positive regulation of AICD" BROAD [GOC:add]
synonym: "positive regulation of antigen-driven apoptosis" BROAD [GOC:add]
synonym: "stimulation of activation-induced cell death of T cells" NARROW [GOC:add]
synonym: "up regulation of activation-induced cell death of T cells" EXACT [GOC:add]
synonym: "up-regulation of activation-induced cell death of T cells" EXACT [GOC:add]
synonym: "upregulation of activation-induced cell death of T cells" EXACT [GOC:add]
is_a: GO:0070234 ! positive regulation of T cell apoptosis
is_a: GO:0070235 ! regulation of activation-induced cell death of T cells
relationship: positively_regulates GO:0006924 ! activation-induced cell death of T cells

[Term]
id: GO:0070238
name: activated T cell autonomous cell death
namespace: biological_process
def: "A type of T cell apoptosis that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen via the accumulation of pro-apoptotic gene products and decrease in anti-apoptotic gene products." [GOC:add, ISBN:0781765196]
synonym: "ACAD" BROAD [GOC:add]
synonym: "activated cell autonomous cell death" BROAD [GOC:add]
synonym: "activated T cell apoptosis" BROAD [GOC:add]
synonym: "activated T lymphocyte autonomous cell death" EXACT [GOC:add]
synonym: "activated T-cell autonomous cell death" EXACT [GOC:add]
synonym: "activated T-lymphocyte autonomous cell death" EXACT [GOC:add]
is_a: GO:0070231 ! T cell apoptosis
relationship: part_of GO:0043029 ! T cell homeostasis

[Term]
id: GO:0070239
name: regulation of activated T cell autonomous cell death
namespace: biological_process
def: "Any process that modulates the occurrence or rate of lymphocyte death by apoptosis." [GOC:add, ISBN:0781765196]
synonym: "regulation of ACAD" BROAD [GOC:add]
synonym: "regulation of activated cell autonomous cell death" BROAD [GOC:add]
synonym: "regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add]
synonym: "regulation of activated T-cell autonomous cell death" EXACT [GOC:add]
synonym: "regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0032844 ! regulation of homeostatic process
is_a: GO:0070232 ! regulation of T cell apoptosis
relationship: regulates GO:0070238 ! activated T cell autonomous cell death

[Term]
id: GO:0070240
name: negative regulation of activated T cell autonomous cell death
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte death by apoptosis." [GOC:add, ISBN:0781765196]
synonym: "down regulation of activated T cell autonomous cell death" EXACT [GOC:add]
synonym: "down-regulation of activated T cell autonomous cell death" EXACT [GOC:add]
synonym: "downregulation of activated T cell autonomous cell death" EXACT [GOC:add]
synonym: "inhibition of activated T cell autonomous cell death" NARROW [GOC:add]
synonym: "negative regulation of ACAD" BROAD [GOC:add]
synonym: "negative regulation of activated cell autonomous cell death" BROAD [GOC:add]
synonym: "negative regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "negative regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add]
synonym: "negative regulation of activated T-cell autonomous cell death" EXACT [GOC:add]
synonym: "negative regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add]
is_a: GO:0070233 ! negative regulation of T cell apoptosis
is_a: GO:0070239 ! regulation of activated T cell autonomous cell death
relationship: negatively_regulates GO:0070238 ! activated T cell autonomous cell death

[Term]
id: GO:0070241
name: positive regulation of activated T cell autonomous cell death
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptosis." [GOC:add, ISBN:0781765196]
synonym: "activation of activated T cell autonomous cell death" NARROW [GOC:add]
synonym: "positive regulation of ACAD" BROAD [GOC:add]
synonym: "positive regulation of activated cell autonomous cell death" BROAD [GOC:add]
synonym: "positive regulation of activated T cell apoptosis" BROAD [GOC:add]
synonym: "positive regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add]
synonym: "positive regulation of activated T-cell autonomous cell death" EXACT [GOC:add]
synonym: "positive regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add]
synonym: "stimulation of activated T cell autonomous cell death" NARROW [GOC:add]
synonym: "up regulation of activated T cell autonomous cell death" EXACT [GOC:add]
synonym: "up-regulation of activated T cell autonomous cell death" EXACT [GOC:add]
synonym: "upregulation of activated T cell autonomous cell death" EXACT [GOC:add]
is_a: GO:0070234 ! positive regulation of T cell apoptosis
is_a: GO:0070239 ! regulation of activated T cell autonomous cell death
relationship: positively_regulates GO:0070238 ! activated T cell autonomous cell death

[Term]
id: GO:0070242
name: thymocyte apoptosis
namespace: biological_process
def: "The process of apoptosis in a thymocyte." [GOC:add, ISBN:0781765196]
comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893).
synonym: "immature T cell apoptosis" RELATED [GOC:add]
is_a: GO:0070231 ! T cell apoptosis

[Term]
id: GO:0070243
name: regulation of thymocyte apoptosis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of thymocyte death by apoptosis." [GOC:add, ISBN:0781765196]
comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893).
synonym: "regulation of immature T cell apoptosis" RELATED [GOC:add]
is_a: GO:0070232 ! regulation of T cell apoptosis
relationship: regulates GO:0070242 ! thymocyte apoptosis

[Term]
id: GO:0070244
name: negative regulation of thymocyte apoptosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte death by apoptosis." [GOC:add, ISBN:0781765196]
comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893).
synonym: "down regulation of thymocyte apoptosis" EXACT [GOC:add]
synonym: "down-regulation of thymocyte apoptosis" EXACT [GOC:add]
synonym: "downregulation of thymocyte apoptosis" EXACT [GOC:add]
synonym: "inhibition of thymocyte apoptosis" NARROW [GOC:add]
synonym: "negative regulation of immature T cell apoptosis" RELATED [GOC:add]
is_a: GO:0070233 ! negative regulation of T cell apoptosis
is_a: GO:0070243 ! regulation of thymocyte apoptosis
relationship: negatively_regulates GO:0070242 ! thymocyte apoptosis

[Term]
id: GO:0070245
name: positive regulation of thymocyte apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thymocyte death by apoptosis." [GOC:add, ISBN:0781765196]
comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893).
synonym: "activation of thymocyte apoptosis" NARROW [GOC:add]
synonym: "positive regulation of immature T cell apoptosis" RELATED [GOC:add]
synonym: "stimulation of thymocyte apoptosis" NARROW [GOC:add]
synonym: "up regulation of thymocyte apoptosis" EXACT [GOC:add]
synonym: "up-regulation of thymocyte apoptosis" EXACT [GOC:add]
synonym: "upregulation of thymocyte apoptosis" EXACT [GOC:add]
is_a: GO:0070234 ! positive regulation of T cell apoptosis
is_a: GO:0070243 ! regulation of thymocyte apoptosis
relationship: positively_regulates GO:0070242 ! thymocyte apoptosis

[Term]
id: GO:0070246
name: natural killer cell apoptosis
namespace: biological_process
def: "The process of apoptosis in a natural killer cell." [GOC:add, PMID:15728472]
synonym: "NK cell apoptosis" EXACT [GOC:add]
is_a: GO:0070227 ! lymphocyte apoptosis

[Term]
id: GO:0070247
name: regulation of natural killer cell apoptosis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of natural killer cell death by apoptosis." [GOC:add, ISBN:0781765196]
synonym: "regulation of NK cell apoptosis" EXACT [GOC:add]
is_a: GO:0070228 ! regulation of lymphocyte apoptosis
relationship: regulates GO:0070246 ! natural killer cell apoptosis

[Term]
id: GO:0070248
name: negative regulation of natural killer cell apoptosis
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of natural killer cell death by apoptosis." [GOC:add, ISBN:0781765196]
synonym: "down regulation of natural killer cell apoptosis" EXACT [GOC:add]
synonym: "down-regulation of natural killer cell apoptosis" EXACT [GOC:add]
synonym: "downregulation of natural killer cell apoptosis" EXACT [GOC:add]
synonym: "inhibition of natural killer cell apoptosis" NARROW [GOC:add]
synonym: "negative regulation of NK cell apoptosis" EXACT [GOC:add]
is_a: GO:0070229 ! negative regulation of lymphocyte apoptosis
is_a: GO:0070247 ! regulation of natural killer cell apoptosis
relationship: negatively_regulates GO:0070246 ! natural killer cell apoptosis

[Term]
id: GO:0070249
name: positive regulation of natural killer cell apoptosis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of natural killer cell death by apoptosis." [GOC:add, ISBN:0781765196]
synonym: "activation of natural killer cell apoptosis" NARROW [GOC:add]
synonym: "positive regulation of NK cell apoptosis" EXACT [GOC:add]
synonym: "stimulation of natural killer cell apoptosis" NARROW [GOC:add]
synonym: "up regulation of natural killer cell apoptosis" EXACT [GOC:add]
synonym: "up-regulation of natural killer cell apoptosis" EXACT [GOC:add]
synonym: "upregulation of natural killer cell apoptosis" EXACT [GOC:add]
is_a: GO:0070230 ! positive regulation of lymphocyte apoptosis
is_a: GO:0070247 ! regulation of natural killer cell apoptosis
relationship: positively_regulates GO:0070246 ! natural killer cell apoptosis

[Term]
id: GO:0070250
name: mating projection membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a mating projection, the projection formed by unicellular fungi in response to mating pheromone." [GOC:jp]
synonym: "shmoo membrane" NARROW [GOC:jp]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0005937 ! mating projection

[Term]
id: GO:0070251
name: pristanate-CoA ligase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA." [GOC:pde, PMID:10198260]
subset: gosubset_prok
synonym: "pristanate:CoA ligase (AMP-forming)" EXACT [GOc:mah]
synonym: "pristanoyl-CoA ligase activity" EXACT [GOC:mah]
xref: EC:6.2.1.24
xref: MetaCyc:PHYTANATE--COA-LIGASE-RXN
xref: Reactome:389766 "pristanate-CoA ligase activity"
is_a: GO:0016878 ! acid-thiol ligase activity

[Term]
id: GO:0070252
name: actin-mediated cell contraction
namespace: biological_process
def: "The actin filament-based process by which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body." [GOC:mah]
is_a: GO:0030029 ! actin filament-based process

[Term]
id: GO:0070253
name: somatostatin secretion
namespace: biological_process
def: "The regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:mah]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0070254
name: mucus secretion
namespace: biological_process
def: "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function." [GOC:add, ISBN:068340007X, ISBN:0721662544]
synonym: "mucus production" EXACT [GOC:add]
is_a: GO:0007589 ! body fluid secretion

[Term]
id: GO:0070255
name: regulation of mucus secretion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or group of cells." [GOC:add]
synonym: "regulation of mucus production" EXACT [GOC:add]
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0070254 ! mucus secretion

[Term]
id: GO:0070256
name: negative regulation of mucus secretion
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or group of cells." [GOC:add]
synonym: "negative regulation of mucus production" EXACT [GOC:add]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0070255 ! regulation of mucus secretion
relationship: negatively_regulates GO:0070254 ! mucus secretion

[Term]
id: GO:0070257
name: positive regulation of mucus secretion
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or group of cells." [GOC:add]
synonym: "positive regulation of mucus production" EXACT [GOC:add]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0070255 ! regulation of mucus secretion
relationship: positively_regulates GO:0070254 ! mucus secretion

[Term]
id: GO:0070258
name: inner membrane complex
namespace: cellular_component
def: "A membrane structure formed of two closely aligned lipid bilayers that lie beneath the plasma membrane and form part of the pellicle surrounding an apicomplexan parasite cell." [GOC:mah, PMID:12456714]
is_a: GO:0044464 ! cell part
relationship: part_of GO:0020039 ! pellicle

[Term]
id: GO:0070259
name: tyrosyl-DNA phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of phosphotyrosyl moieties formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA." [GOC:elh, PMID:16751265]
comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'.
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0070260
name: 5'-tyrosyl-DNA phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of 5'-phosphotyrosyl moieties formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA." [PMID:16751265]
comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'.
is_a: GO:0070259 ! tyrosyl-DNA phosphodiesterase activity

[Term]
id: GO:0070262
name: peptidyl-serine dephosphorylation
namespace: biological_process
def: "The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine." [GOC:bf]
is_a: GO:0006470 ! protein amino acid dephosphorylation

[Term]
id: GO:0070263
name: external side of fungal-type cell wall
namespace: cellular_component
def: "The side of the fungal-type cell wall that is opposite to the side that faces the cell and its contents." [GOC:mah]
is_a: GO:0010339 ! external side of cell wall
relationship: part_of GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0070264
name: transcription factor TFIIIE complex
namespace: cellular_component
def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIE contains a specific subset of ribosomal proteins." [GOC:jp, PMID:19116144]
is_a: GO:0005667 ! transcription factor complex
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0070265
name: necrotic cell death
namespace: biological_process
def: "A cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [PMID:18846107]
comment: Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals.
synonym: "cellular necrosis" EXACT [GOC:add]
synonym: "necrosis" BROAD [GOC:mah]
is_a: GO:0008219 ! cell death

[Term]
id: GO:0070266
name: necroptosis
namespace: biological_process
def: "A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors and Toll-like receptors." [GOC:mah, PMID:18846107]
synonym: "programmed necrotic cell death" EXACT [GOC:mah]
is_a: GO:0070265 ! necrotic cell death

[Term]
id: GO:0070267
name: oncosis
namespace: biological_process
def: "A cellular process that results in swelling of the cell body, and that is morphologically characteristic of necrotic cell death." [PMID:17873035, PMID:18846107]
comment: Note that oncosis is sometimes described as a type of cell death, but recent nomenclature recommendations define it as a feature of necrotic cell death rather than a distinct mode of cell death.
is_a: GO:0045793 ! positive regulation of cell size
relationship: part_of GO:0070265 ! necrotic cell death

[Term]
id: GO:0070268
name: cornification
namespace: biological_process
def: "A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability)." [PMID:18846107]
is_a: GO:0012501 ! programmed cell death
relationship: part_of GO:0031424 ! keratinization

[Term]
id: GO:0070269
name: pyroptosis
namespace: biological_process
def: "A type of programmed cell death that results from the apical activation of caspase-1." [PMID:18846107]
is_a: GO:0012501 ! programmed cell death

[Term]
id: GO:0070270
name: mitotic catastrophe
namespace: biological_process
def: "A type of programmed cell death that occurs during or shortly after a dysregulated or failed mitosis and can be accompanied by morphological alterations including micronucleation and multinucleation." [PMID:18846107]
synonym: "cell death occurring during metaphase" RELATED [PMID:18846107]
synonym: "cell death preceded by multinucleation" RELATED [PMID:18846107]
is_a: GO:0012501 ! programmed cell death

[Term]
id: GO:0070271
name: protein complex biogenesis
namespace: biological_process
def: "The cellular process by which a protein complex is synthesized, aggregates, and bonds together. Includes the synthesis of the constituent protein molecules, and those protein modifications that are involved in synthesis or assembly of the complex." [GOC:mah]
subset: goslim_yeast
subset: gosubset_prok
synonym: "protein complex biogenesis and assembly" EXACT [GOC:mah]
is_a: GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0070272
name: proton-transporting ATP synthase complex biogenesis
namespace: biological_process
def: "The biogenesis of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mah, PMID:19103153]
synonym: "F-type ATPase complex biogenesis" EXACT [GOC:mah]
is_a: GO:0070271 ! protein complex biogenesis

[Term]
id: GO:0070273
name: phosphatidylinositol-4-phosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a phosphorylated derivative of phosphatidylinositol." [GOC:mah]
is_a: GO:0035091 ! phosphoinositide binding

[Term]
id: GO:0070274
name: RES complex
namespace: cellular_component
def: "A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p." [PMID:15565172, PMID:18809678, PMID:19010333, PMID:19033360]
synonym: "pre-mRNA retention and splicing complex" EXACT [GOC:sre]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070275
name: aerobic ammonia oxidation to nitrite via pyruvic oxime
namespace: biological_process
def: "The metabolic process by which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen. Hydroxylamine is produced enzymatically, and, in the presence of pyruvate, forms pyruvic oxime in a spontaneous, non-enzymatic reaction; pyruvic oxime is then converted to nitrite." [MetaCyc:PWY-2242]
subset: gosubset_prok
xref: MetaCyc:PWY-2242
is_a: GO:0019329 ! ammonia oxidation

[Term]
id: GO:0070276
name: halogen metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any halogen, elements of Group VII; includes metabolism of halogen-containing compounds." [ChEBI:22473, GOC:mah]
synonym: "halogen metabolism" EXACT []
is_a: GO:0010817 ! regulation of hormone levels
is_a: GO:0044281 ! small molecule metabolic process

[Term]
id: GO:0070277
name: iodide oxidation
namespace: biological_process
def: "The chemical reactions and pathways by which iodide is converted to diiodine, with the concomitant loss of electrons." [GOC:mah, MetaCyc:IODIDE-PEROXIDASE-RXN]
is_a: GO:0070276 ! halogen metabolic process

[Term]
id: GO:0070278
name: extracellular matrix constituent secretion
namespace: biological_process
def: "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:mah]
synonym: "ECM constituent secretion" EXACT [GOC:mah]
synonym: "ECM secretion" EXACT [GOC:mah]
is_a: GO:0032940 ! secretion by cell
relationship: part_of GO:0030198 ! extracellular matrix organization

[Term]
id: GO:0070279
name: vitamin B6 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah]
is_a: GO:0019842 ! vitamin binding

[Term]
id: GO:0070280
name: pyridoxal binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6." [ChEBI:17310, GOC:mah]
is_a: GO:0070279 ! vitamin B6 binding

[Term]
id: GO:0070281
name: pyridoxamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6." [ChEBI:16410, GOC:mah]
is_a: GO:0070279 ! vitamin B6 binding

[Term]
id: GO:0070282
name: pyridoxine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pyridoxine, 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6." [ChEBI:16709, GOC:mah]
is_a: GO:0070279 ! vitamin B6 binding

[Term]
id: GO:0070283
name: radical SAM enzyme activity
namespace: molecular_function
def: "Catalysis of a reaction in which S-adenosyl-L-methionine (SAM) undergoes reductive cleavage to serve as a source of the 5'-deoxyadenosyl radical." [PMID:17291766, PMID:18307109]
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0070284
name: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-aminoimidazole ribonucleotide (AIR) + S-adenosylmethionine (SAM) = 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P) + 5'deoxyadenosine (5-dAdo)." [PMID:18953358]
synonym: "HMP-P synthase activity" EXACT [PMID:18953358]
synonym: "ThiC" RELATED [PMID:18953358]
is_a: GO:0016853 ! isomerase activity
is_a: GO:0070283 ! radical SAM enzyme activity

[Term]
id: GO:0070285
name: pigment cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate." [GOC:cvs]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0050931 ! pigment cell differentiation

[Term]
id: GO:0070286
name: axonemal dynein complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:mah, PMID:19052621]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0070287
name: ferritin receptor activity
namespace: molecular_function
def: "Combining with ferritin, an iron-storing protein complex, to initiate a change in cell activity." [GOC:mah, PMID:17459943, PMID:19154717]
synonym: "ferritin complex receptor activity" EXACT [GOC:mah]
is_a: GO:0004888 ! transmembrane receptor activity

[Term]
id: GO:0070288
name: ferritin complex
namespace: cellular_component
def: "A protein complex that binds iron and acts as a major iron storage system. Intracellular and extracellular ferritin complexes have different ratios of two types of ferritin monomer, the L (light) chain and H (heavy) chain." [GOC:mah, PMID:19154717]
is_a: GO:0043234 ! protein complex

[Term]
id: GO:0070289
name: extracellular ferritin complex
namespace: cellular_component
def: "A ferritin complex located in the extracellular region. Extracellular ferritin complexes contain L (light) chains but few or no H (heavy) chains." [GOC:mah, PMID:19154717]
synonym: "serum ferritin complex" RELATED [PMID:19154717]
is_a: GO:0044421 ! extracellular region part
is_a: GO:0070288 ! ferritin complex

[Term]
id: GO:0070290
name: NAPE-specific phospholipase D activity
namespace: molecular_function
def: "Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE)." [GOC:elh, PMID:14634025, PMID:15878693]
xref: EC:3.1.4.4
is_a: GO:0004620 ! phospholipase activity
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0070291
name: N-acylethanolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acylethanolamines." [GOC:elh, PMID:14634025, PMID:15878693]
synonym: "N-acylethanolamine metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15877693]
synonym: "NAE metabolic process" EXACT [GOC:elh, PMID:14634025, PMID:15877693]
synonym: "NAE metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15877693]
is_a: GO:0006580 ! ethanolamine metabolic process

[Term]
id: GO:0070292
name: N-acylphosphatidylethanolamine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving N-acylethanolamines." [GOC:elh, PMID:14634025, PMID:15878693]
synonym: "N-acylphosphatidylethanolamine metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15877693]
synonym: "NAPE metabolic process" EXACT [GOC:elh, PMID:14634025, PMID:15877693]
synonym: "NAPE metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15877693]
is_a: GO:0046337 ! phosphatidylethanolamine metabolic process

[Term]
id: GO:0070293
name: renal absorption
namespace: biological_process
def: "A renal system process by which water, ions, and glucose are taken up from the collecting ducts and proximal and distal loops of the nephron." [GOC:dph, GOC:mah]
synonym: "nephron absorption" EXACT [GOC:mah]
synonym: "renal reabsorption" EXACT [GOC:dph]
is_a: GO:0003014 ! renal system process

[Term]
id: GO:0070294
name: renal sodium ion absorption
namespace: biological_process
def: "A renal system process by which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron." [GOC:dph, GOC:mah]
synonym: "nephron sodium ion absorption" EXACT [GOC:mah]
synonym: "renal sodium ion reabsorption" EXACT [GOC:dph]
is_a: GO:0003096 ! renal sodium ion transport
is_a: GO:0070293 ! renal absorption

[Term]
id: GO:0070295
name: renal water absorption
namespace: biological_process
def: "A renal system process by which water is taken up from the collecting ducts and proximal and distal loops of the nephron." [GOC:dph, GOC:mah]
synonym: "nephron water absorption" EXACT [GOC:mah]
synonym: "renal water reabsorption" EXACT [GOC:dph]
is_a: GO:0003097 ! renal water transport
is_a: GO:0070293 ! renal absorption

[Term]
id: GO:0070296
name: sarcoplasmic reticulum calcium ion transport
namespace: biological_process
def: "The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum." [GOC:vk]
is_a: GO:0006816 ! calcium ion transport
is_a: GO:0046907 ! intracellular transport

[Term]
id: GO:0070297
name: regulation of two-component signal transduction system (phosphorelay)
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction via a two-component phosphorelay signal transduction system." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah]
synonym: "regulation of two-component signal transduction system (phosphorelay)" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0000160 ! two-component signal transduction system (phosphorelay)

[Term]
id: GO:0070298
name: negative regulation of two-component signal transduction system (phosphorelay)
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction via a two-component phosphorelay signal transduction system." [GOC:mah]
synonym: "down regulation of two-component signal transduction" EXACT [GOC:mah]
synonym: "down-regulation of two-component signal transduction" EXACT [GOC:mah]
synonym: "downregulation of two-component signal transduction" EXACT [GOC:mah]
synonym: "inhibition of two-component signal transduction" NARROW [GOC:mah]
synonym: "negative regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah]
synonym: "negative regulation of two-component signal transduction system (phosphorelay)" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0070297 ! regulation of two-component signal transduction system (phosphorelay)
relationship: negatively_regulates GO:0000160 ! two-component signal transduction system (phosphorelay)

[Term]
id: GO:0070299
name: positive regulation of two-component signal transduction system (phosphorelay)
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction via a two-component phosphorelay signal transduction system." [GOC:mah]
synonym: "activation of two-component signal transduction" NARROW [GOC:mah]
synonym: "positive regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah]
synonym: "positive regulation of two-component signal transduction system (phosphorelay)" EXACT [GOC:mah]
synonym: "stimulation of two-component signal transduction" NARROW [GOC:mah]
synonym: "up regulation of two-component signal transduction" EXACT [GOC:mah]
synonym: "up-regulation of two-component signal transduction" EXACT [GOC:mah]
synonym: "upregulation of two-component signal transduction" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0070297 ! regulation of two-component signal transduction system (phosphorelay)
relationship: positively_regulates GO:0000160 ! two-component signal transduction system (phosphorelay)

[Term]
id: GO:0070300
name: phosphatidic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ChEBI:16337, GOC:jp, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "phosphatidate binding" EXACT [GOC:jp]
is_a: GO:0005543 ! phospholipid binding

[Term]
id: GO:0070301
name: cellular response to hydrogen peroxide
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [ChEBI:16240, GOC:mah]
is_a: GO:0034614 ! cellular response to reactive oxygen species
is_a: GO:0042542 ! response to hydrogen peroxide

[Term]
id: GO:0070302
name: regulation of stress-activated protein kinase signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling pathway." [GOC:mah]
synonym: "regulation of SAPK signaling pathway" EXACT [GOC:mah]
synonym: "regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0031098 ! stress-activated protein kinase signaling pathway

[Term]
id: GO:0070303
name: negative regulation of stress-activated protein kinase signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling pathway." [GOC:mah]
synonym: "down regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
synonym: "down-regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
synonym: "downregulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
synonym: "inhibition of stress-activated protein kinase signaling pathway" NARROW [GOC:mah]
synonym: "negative regulation of SAPK signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling pathway
relationship: negatively_regulates GO:0031098 ! stress-activated protein kinase signaling pathway

[Term]
id: GO:0070304
name: positive regulation of stress-activated protein kinase signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling pathway." [GOC:mah]
synonym: "activation of stress-activated protein kinase signaling pathway" NARROW [GOC:mah]
synonym: "positive regulation of SAPK signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah]
synonym: "stimulation of stress-activated protein kinase signaling pathway" NARROW [GOC:mah]
synonym: "up regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
synonym: "up-regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
synonym: "upregulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling pathway
relationship: positively_regulates GO:0031098 ! stress-activated protein kinase signaling pathway

[Term]
id: GO:0070305
name: response to cGMP
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus." [GOC:sl]
synonym: "response to 3',5' cGMP" EXACT [GOC:mah]
synonym: "response to 3',5'-cGMP" EXACT [GOC:mah]
synonym: "response to cyclic GMP" EXACT [GOC:mah]
synonym: "response to guanosine 3',5'-cyclophosphate" EXACT [GOC:mah]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0070306
name: lens fiber cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities." [GOC:mah, PMID:7693735]
synonym: "lens fibre cell differentiation" EXACT [GOC:mah]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0002088 ! lens development in camera-type eye

[Term]
id: GO:0070307
name: lens fiber cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735]
synonym: "lens fibre cell development" EXACT [GOC:mah]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0070306 ! lens fiber cell differentiation

[Term]
id: GO:0070308
name: lens fiber cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735]
synonym: "lens fibre cell fate commitment" EXACT [GOC:mah]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0070306 ! lens fiber cell differentiation

[Term]
id: GO:0070309
name: lens fiber cell morphogenesis
namespace: biological_process
def: "The process by which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735]
synonym: "elongation of lens fiber cell" NARROW [GOC:mah, GOC:vk]
synonym: "lens fiber cell morphogenesis during differentiation" EXACT systematic_synonym [GOC:mah]
synonym: "lens fibre cell morphogenesis" EXACT [GOC:mah]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0002089 ! lens morphogenesis in camera-type eye
relationship: part_of GO:0070307 ! lens fiber cell development

[Term]
id: GO:0070310
name: ATR-ATRIP complex
namespace: cellular_component
def: "A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A." [GOC:mah, PMID:14724280]
synonym: "Mec1-Lcd1 complex" NARROW [PMID:17339343]
synonym: "Rad3-Rad26 complex" NARROW [PMID:17339343]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070311
name: nucleosomal methylation activator complex
namespace: cellular_component
def: "A protein complex that contains eight subunits in common with the SWI/SNF complex, plus the ATPase BRG1 (SMARCA4) and the histone methyltransferase CARM1; the complex is involved in regulating nuclear receptor-dependent transcription." [GOC:mah, PMID:14729568]
synonym: "NUMAC" EXACT [PMID:14729568]
is_a: GO:0016585 ! chromatin remodeling complex
is_a: GO:0035097 ! histone methyltransferase complex

[Term]
id: GO:0070312
name: RAD52-ERCC4-ERCC1 complex
namespace: cellular_component
def: "A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein." [PMID:14734547]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0070313
name: RGS6-DNMT1-DMAP1 complex
namespace: cellular_component
def: "A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1." [GOC:mah, PMID:14734556]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070314
name: G1 to G0 transition
namespace: biological_process
def: "A process by which progression through the cell cycle is halted during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence." [GOC:mah, ISBN:0815316194]
synonym: "cell cycle quiescence" RELATED [GOC:mah]
synonym: "G1/G0 transition" EXACT [GOC:mah]
synonym: "stationary phase" RELATED [GOC:mah]
is_a: GO:0007050 ! cell cycle arrest

[Term]
id: GO:0070315
name: G1 to G0 transition involved in cell differentiation
namespace: biological_process
def: "A process by which progression through the cell cycle is halted during G1 phase, whereupon the cell enters G0 phase, in the context of cell differentiation." [GOC:mah, ISBN:0815316194]
synonym: "G1/G0 transition involved in cell differentiation" EXACT [GOC:mah]
is_a: GO:0070314 ! G1 to G0 transition
relationship: part_of GO:0030154 ! cell differentiation

[Term]
id: GO:0070316
name: regulation of G0 to G1 transition
namespace: biological_process
def: "A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah]
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0045023 ! G0 to G1 transition

[Term]
id: GO:0070317
name: negative regulation of G0 to G1 transition
namespace: biological_process
def: "A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah]
synonym: "maintenance of G0 arrest" EXACT [GOC:mah]
synonym: "maintenance of G0 phase" EXACT [GOC:mah]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0045786 ! negative regulation of cell cycle
is_a: GO:0070316 ! regulation of G0 to G1 transition
relationship: negatively_regulates GO:0045023 ! G0 to G1 transition

[Term]
id: GO:0070318
name: positive regulation of G0 to G1 transition
namespace: biological_process
def: "A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah]
is_a: GO:0045787 ! positive regulation of cell cycle
is_a: GO:0070316 ! regulation of G0 to G1 transition
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0045023 ! G0 to G1 transition

[Term]
id: GO:0070319
name: Golgi to plasma membrane transport vesicle
namespace: cellular_component
def: "A transport vesicle that mediates transport from the Golgi to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]
synonym: "Golgi-plasma membrane transport vesicle" EXACT [GOC:mah]
is_a: GO:0070382 ! exocytic vesicle

[Term]
id: GO:0070320
name: inward rectifier potassium channel inhibitor activity
namespace: molecular_function
def: "Stops, prevents, or reduces the activity of an inwardly rectifying potassium channel." [GOC:mah]
is_a: GO:0019870 ! potassium channel inhibitor activity

[Term]
id: GO:0070321
name: regulation of translation in response to nitrogen starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah]
is_a: GO:0006995 ! cellular response to nitrogen starvation
is_a: GO:0043555 ! regulation of translation in response to stress

[Term]
id: GO:0070322
name: negative regulation of translation in response to nitrogen starvation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah]
synonym: "down regulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
synonym: "down-regulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
synonym: "downregulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
synonym: "inhibition of translation in response to nitrogen starvation" NARROW [GOC:mah]
is_a: GO:0032055 ! negative regulation of translation in response to stress
is_a: GO:0070321 ! regulation of translation in response to nitrogen starvation

[Term]
id: GO:0070323
name: positive regulation of translation in response to nitrogen starvation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah]
synonym: "activation of translation in response to nitrogen starvation" NARROW [GOC:mah]
synonym: "stimulation of translation in response to nitrogen starvation" NARROW [GOC:mah]
synonym: "up regulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
synonym: "up-regulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
synonym: "upregulation of translation in response to nitrogen starvation" EXACT [GOC:mah]
is_a: GO:0032056 ! positive regulation of translation in response to stress
is_a: GO:0070321 ! regulation of translation in response to nitrogen starvation

[Term]
id: GO:0070324
name: thyroid hormone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland." [GOC:rph]
synonym: "thyroxine binding" NARROW [GOC:mah]
synonym: "triiodothyronine binding" NARROW [GOC:mah]
is_a: GO:0042562 ! hormone binding

[Term]
id: GO:0070325
name: lipoprotein receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a lipoprotein receptor." [GOC:BHF, GOC:rl]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0070326
name: very-low-density lipoprotein receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a very-low-density lipoprotein receptor." [GOC:BHF, GOC:mah]
synonym: "apolipoprotein E receptor binding" RELATED [GOC:rl]
synonym: "VLDL receptor binding" EXACT [GOC:mah]
synonym: "VLDLR binding" EXACT [GOC:mah]
is_a: GO:0070325 ! lipoprotein receptor binding

[Term]
id: GO:0070327
name: thyroid hormone transport
namespace: biological_process
def: "The directed movement of thyroid hormone into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:rph]
synonym: "thyroxine transport" NARROW [GOC:mah]
synonym: "triiodothyronine transport" NARROW [GOC:mah]
is_a: GO:0009914 ! hormone transport
is_a: GO:0051937 ! catecholamine transport

[Term]
id: GO:0070328
name: triglyceride homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of triglyceride within an organism or cell." [GOC:BHF, GOC:mah]
synonym: "triacylglycerol homeostasis" EXACT [GOC:rl]
is_a: GO:0055088 ! lipid homeostasis

[Term]
id: GO:0070329
name: tRNA seleno-modification
namespace: biological_process
def: "The substitution of a selenium atom for a sulfur atom in a ribonucleotide in a tRNA molecule." [GOC:jsg, PMID:14594807]
subset: gosubset_prok
synonym: "tRNA base modification to selenouridine" EXACT [GOC:mah]
is_a: GO:0001887 ! selenium metabolic process
is_a: GO:0006400 ! tRNA modification

[Term]
id: GO:0070330
name: aromatase activity
namespace: molecular_function
def: "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb]
subset: gosubset_prok
synonym: "estrogen synthetase activity" NARROW []
xref: EC:1.14.14.1
xref: MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN
xref: UM-BBD_enzymeID:e0551
is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0070331
name: CD20-Lck-Fyn complex
namespace: cellular_component
def: "A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck and Fyn." [GOC:mah, PMID:7545683]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0070332
name: CD20-Lck-Lyn-Fyn complex
namespace: cellular_component
def: "A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck, Lyn and Fyn." [GOC:mah, PMID:7545683]
is_a: GO:0043234 ! protein complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0070333
name: alpha6-beta4 integrin-Shc-Grb2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the adaptor proteins Shc and Grb2." [PMID:7556090]
synonym: "ITGA6-ITGB4-SHC-GRB2 complex" NARROW [CORUM:3096]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070334
name: alpha6-beta4 integrin-laminin 5 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to laminin 5." [GOC:mah, PMID:7556090]
synonym: "ITGA6-ITGB4-LAMA5 complex" NARROW [CORUM:2322]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070335
name: aspartate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with glutamate, the anion of 2-aminobutanedioic acid." [GOC:mah]
synonym: "aspartic acid binding" EXACT [GOC:mah]
is_a: GO:0016597 ! amino acid binding

[Term]
id: GO:0070336
name: flap-structured DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule." [GOC:mah, PMID:15189154]
subset: gosubset_prok
is_a: GO:0043566 ! structure-specific DNA binding

[Term]
id: GO:0070337
name: 3'-flap-structured DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule." [GOC:mah, PMID:15189154]
subset: gosubset_prok
is_a: GO:0070336 ! flap-structured DNA binding

[Term]
id: GO:0070338
name: 5'-flap-structured DNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a 5'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 5'-end of DNA or RNA protrudes from a double-stranded DNA molecule. 5'-flap structures can be formed during DNA repair or lagging strand synthesis; in the latter case RNA flaps form from lagging strand RNA primers." [GOC:mah, PMID:15189154]
subset: gosubset_prok
is_a: GO:0070336 ! flap-structured DNA binding

[Term]
id: GO:0070339
name: response to bacterial lipopeptide
namespace: biological_process
def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus." [GOC:add, PMID:12077222]
is_a: GO:0032493 ! response to bacterial lipoprotein

[Term]
id: GO:0070340
name: detection of bacterial lipopeptide
namespace: biological_process
def: "The series of events in which a bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal." [GOC:add, PMID:12077222]
is_a: GO:0042494 ! detection of bacterial lipoprotein
is_a: GO:0070339 ! response to bacterial lipopeptide

[Term]
id: GO:0070341
name: fat cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat." [GOC:mah, GOC:sl]
synonym: "adipocyte proliferation" EXACT [GOC:sl]
synonym: "adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0070342
name: brown fat cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of brown fat cells by cell division, resulting in the expansion of their population. A brown fat cell is a fat cell found the thermogenic form of adipose tissue found in newborns of many species." [CL:0000449, GOC:mah, GOC:sl]
synonym: "brown adipocyte proliferation" EXACT [GOC:sl]
synonym: "brown adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070343
name: white fat cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of white fat cells by cell division, resulting in the expansion of their population." [CL:0000448, GOC:mah, GOC:sl]
synonym: "white adipocyte proliferation" EXACT [GOC:sl]
synonym: "white adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070344
name: regulation of fat cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "regulation of adipocyte proliferation" EXACT [GOC:sl]
synonym: "regulation of adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0042127 ! regulation of cell proliferation
relationship: regulates GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070345
name: negative regulation of fat cell proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "down regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "inhibition of fat cell proliferation" NARROW [GOC:mah]
synonym: "negative regulation of adipocyte proliferation" EXACT [GOC:sl]
synonym: "negative regulation of adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0070344 ! regulation of fat cell proliferation
relationship: negatively_regulates GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070346
name: positive regulation of fat cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "activation of fat cell proliferation" NARROW [GOC:mah]
synonym: "positive regulation of adipocyte proliferation" EXACT [GOC:sl]
synonym: "positive regulation of adipose cell proliferation" EXACT [GOC:sl]
synonym: "stimulation of fat cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of fat cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of fat cell proliferation" EXACT [GOC:mah]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0070344 ! regulation of fat cell proliferation
relationship: positively_regulates GO:0070341 ! fat cell proliferation

[Term]
id: GO:0070347
name: regulation of brown fat cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "regulation of brown adipocyte proliferation" EXACT [GOC:sl]
synonym: "regulation of brown adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070344 ! regulation of fat cell proliferation
relationship: regulates GO:0070342 ! brown fat cell proliferation

[Term]
id: GO:0070348
name: negative regulation of brown fat cell proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "down regulation of brown fat cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of brown fat cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of brown fat cell proliferation" EXACT [GOC:mah]
synonym: "inhibition of brown fat cell proliferation" NARROW [GOC:mah]
synonym: "negative regulation of brown adipocyte proliferation" EXACT [GOC:sl]
synonym: "negative regulation of brown adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070345 ! negative regulation of fat cell proliferation
is_a: GO:0070347 ! regulation of brown fat cell proliferation
relationship: negatively_regulates GO:0070342 ! brown fat cell proliferation

[Term]
id: GO:0070349
name: positive regulation of brown fat cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "activation of brown fat cell proliferation" NARROW [GOC:mah]
synonym: "positive regulation of brown adipocyte proliferation" EXACT [GOC:sl]
synonym: "positive regulation of brown adipose cell proliferation" EXACT [GOC:sl]
synonym: "stimulation of brown fat cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of brown fat cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of brown fat cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of brown fat cell proliferation" EXACT [GOC:mah]
is_a: GO:0070346 ! positive regulation of fat cell proliferation
is_a: GO:0070347 ! regulation of brown fat cell proliferation
relationship: positively_regulates GO:0070342 ! brown fat cell proliferation

[Term]
id: GO:0070350
name: regulation of white fat cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "regulation of white adipocyte proliferation" EXACT [GOC:sl]
synonym: "regulation of white adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070344 ! regulation of fat cell proliferation
relationship: regulates GO:0070343 ! white fat cell proliferation

[Term]
id: GO:0070351
name: negative regulation of white fat cell proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "down regulation of white fat cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of white fat cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of white fat cell proliferation" EXACT [GOC:mah]
synonym: "inhibition of white fat cell proliferation" NARROW [GOC:mah]
synonym: "negative regulation of white adipocyte proliferation" EXACT [GOC:sl]
synonym: "negative regulation of white adipose cell proliferation" EXACT [GOC:sl]
is_a: GO:0070345 ! negative regulation of fat cell proliferation
is_a: GO:0070350 ! regulation of white fat cell proliferation
relationship: negatively_regulates GO:0070343 ! white fat cell proliferation

[Term]
id: GO:0070352
name: positive regulation of white fat cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl]
synonym: "activation of white fat cell proliferation" NARROW [GOC:mah]
synonym: "positive regulation of white adipocyte proliferation" EXACT [GOC:sl]
synonym: "positive regulation of white adipose cell proliferation" EXACT [GOC:sl]
synonym: "stimulation of white fat cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of white fat cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of white fat cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of white fat cell proliferation" EXACT [GOC:mah]
is_a: GO:0070346 ! positive regulation of fat cell proliferation
is_a: GO:0070350 ! regulation of white fat cell proliferation
relationship: positively_regulates GO:0070343 ! white fat cell proliferation

[Term]
id: GO:0070353
name: GATA1-TAL1-TCF3-Lmo2 complex
namespace: cellular_component
def: "A protein complex that contains the zinc finger transcription factor GATA1, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis." [PMID:7568177]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070354
name: GATA2-TAL1-TCF3-Lmo2 complex
namespace: cellular_component
def: "A protein complex that contains the zinc finger transcription factor GATA2, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis." [PMID:7568177]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070355
name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a-complexin II complex
namespace: cellular_component
def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, Rab3a, and complexin II (or orthologs thereof)." [PMID:7654227]
synonym: "SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2, CPLX2)" NARROW [CORUM:1247]
synonym: "STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2-CPLX2 complex" NARROW [CORUM:1247]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070356
name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a complex
namespace: cellular_component
def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Rab3a (or orthologs thereof)." [PMID:7654227]
synonym: "SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2)" NARROW [CORUM:1244]
synonym: "STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2 complex" NARROW [CORUM:1244]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070357
name: alphav-beta3 integrin-CD47 complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to CD47 (also known as IAP)." [PMID:2277087, PMID:7691831]
synonym: "ITGB3-ITGAV-CD47 complex" NARROW [CORUM:2356]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070358
name: actin polymerization-dependent cell motility
namespace: biological_process
def: "A process involved in the controlled movement of a bacterial cell powered by the continuous polymerization of actin at one pole of the cell." [GOC:mah, PMID:15773977]
subset: gosubset_prok
synonym: "cell motility by actin tail formation" EXACT [PMID:15773977]
is_a: GO:0048870 ! cell motility

[Term]
id: GO:0070359
name: actin polymerization-dependent cell motility involved in migration of symbiont in host
namespace: biological_process
def: "A process involved in the controlled movement of a bacterial cell within a host cell, powered by the continuous polymerization of host actin at one pole of the cell." [GOC:jl, GOC:mah, PMID:15773977]
subset: gosubset_prok
synonym: "actin polymerization-dependent cell motility involved in migration of symbiont within host" EXACT []
is_a: GO:0070358 ! actin polymerization-dependent cell motility
relationship: part_of GO:0070360 ! migration of symbiont within host by polymerization of host actin

[Term]
id: GO:0070360
name: migration of symbiont within host by polymerization of host actin
namespace: biological_process
def: "The directional movement of an organism, usually a bacterial cell, from one place to another within its host organism, by a process involving continuous polymerization of host actin at one pole of the symbiont cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:mah]
subset: gosubset_prok
is_a: GO:0044001 ! migration in host

[Term]
id: GO:0070361
name: mitochondrial light strand promoter anti-sense binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the anti-sense strand of the light strand promoter, a promoter located on the light, or cytosine-rich, strand of mitochondrial DNA." [GOC:mah, PMID:9485316]
synonym: "LSP non-coding strand binding" EXACT [PMID:9485316]
synonym: "LSPas binding" EXACT [PMID:9485316]
is_a: GO:0010843 ! promoter binding

[Term]
id: GO:0070362
name: mitochondrial heavy strand promoter anti-sense binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the anti-sense strand of the heavy strand promoter, a promoter located on the heavy, or guanine-rich, strand of mitochondrial DNA." [GOC:mah, PMID:9485316]
synonym: "HSP non-coding strand binding" EXACT [PMID:9485316]
synonym: "HSPas binding" EXACT [PMID:9485316]
is_a: GO:0010843 ! promoter binding

[Term]
id: GO:0070363
name: mitochondrial light strand promoter sense binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the sense strand of the light strand promoter, a promoter located on the light, or cytosine-rich, strand of mitochondrial DNA." [GOC:mah, PMID:9485316]
synonym: "LSP coding strand binding" EXACT [PMID:9485316]
synonym: "LSPs binding" EXACT [PMID:9485316]
is_a: GO:0010843 ! promoter binding

[Term]
id: GO:0070364
name: mitochondrial heavy strand promoter sense binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the sense strand of the heavy strand promoter, a promoter located on the heavy, or guanine-rich, strand of mitochondrial DNA." [GOC:mah, PMID:9485316]
synonym: "HSP coding strand binding" EXACT [PMID:9485316]
synonym: "HSPs binding" EXACT [PMID:9485316]
is_a: GO:0010843 ! promoter binding

[Term]
id: GO:0070365
name: hepatocyte differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver." [CL:0000182, PMID:7588884]
synonym: "liver cell differentiation" EXACT [GOC:mah]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0001889 ! liver development

[Term]
id: GO:0070366
name: regulation of hepatocyte differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl]
synonym: "regulation of liver cell differentiation" EXACT [GOC:sl]
is_a: GO:0045595 ! regulation of cell differentiation
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0070365 ! hepatocyte differentiation

[Term]
id: GO:0070367
name: negative regulation of hepatocyte differentiation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl]
synonym: "down regulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "down-regulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "downregulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "inhibition of hepatocyte differentiation" NARROW [GOC:mah]
synonym: "negative regulation of liver cell differentiation" EXACT [GOC:sl]
is_a: GO:0045596 ! negative regulation of cell differentiation
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0070366 ! regulation of hepatocyte differentiation
relationship: negatively_regulates GO:0070365 ! hepatocyte differentiation

[Term]
id: GO:0070368
name: positive regulation of hepatocyte differentiation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl]
synonym: "activation of hepatocyte differentiation" NARROW [GOC:mah]
synonym: "positive regulation of liver cell differentiation" EXACT [GOC:sl]
synonym: "stimulation of hepatocyte differentiation" NARROW [GOC:mah]
synonym: "up regulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "up-regulation of hepatocyte differentiation" EXACT [GOC:mah]
synonym: "upregulation of hepatocyte differentiation" EXACT [GOC:mah]
is_a: GO:0045597 ! positive regulation of cell differentiation
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0070366 ! regulation of hepatocyte differentiation
relationship: positively_regulates GO:0070365 ! hepatocyte differentiation

[Term]
id: GO:0070369
name: beta-catenin-TCF7L2 complex
namespace: cellular_component
def: "A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:rl, PMID:9065401, PMID:9065402]
subset: gosubset_prok
synonym: "beta-catenin-TCF4 complex" EXACT [PMID:9065401, PMID:9065402]
is_a: GO:0071664 ! catenin-TCF7L2 complex

[Term]
id: GO:0070370
name: cellular heat acclimation
namespace: biological_process
def: "Any process that increases heat tolerance of a cell in response to high temperatures." [GOC:jp]
synonym: "cellular thermotolerance" EXACT [GOC:jp]
is_a: GO:0010286 ! heat acclimation
is_a: GO:0034605 ! cellular response to heat

[Term]
id: GO:0070371
name: ERK1 and ERK2 cascade
namespace: biological_process
def: "A cascade of protein kinase activities, culminating in the phosphorylation and activation of either the ERK1 or ERK2 kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases." [GOC:add, ISBN:0121245462, ISBN:0896039986]
comment: Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2, not other ERK kinases.
synonym: "ERK cascade" BROAD [GOC:add]
synonym: "ERK1 and ERK2 signaling pathway" EXACT [GOC:mah]
synonym: "ERK1 and ERK2 signalling pathway" EXACT [GOC:mah]
synonym: "ERK1 cascade" NARROW [GOC:add]
synonym: "ERK1/2 cascade" EXACT [GOC:add]
synonym: "ERK2 cascade" NARROW [GOC:add]
synonym: "MAPK1 cascade" NARROW [GOC:add]
synonym: "MAPK3 cascade" NARROW [GOC:add]
is_a: GO:0000165 ! MAPKKK cascade

[Term]
id: GO:0070372
name: regulation of ERK1 and ERK2 cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]
synonym: "regulation of ERK cascade" BROAD [GOC:add]
synonym: "regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah]
synonym: "regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah]
synonym: "regulation of ERK1 cascade" NARROW [GOC:add]
synonym: "regulation of ERK1/2 cascade" EXACT [GOC:add]
synonym: "regulation of ERK2 cascade" NARROW [GOC:add]
synonym: "regulation of MAPK1 cascade" NARROW [GOC:add]
synonym: "regulation of MAPK3 cascade" NARROW [GOC:add]
is_a: GO:0043408 ! regulation of MAPKKK cascade
relationship: regulates GO:0070371 ! ERK1 and ERK2 cascade

[Term]
id: GO:0070373
name: negative regulation of ERK1 and ERK2 cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]
synonym: "down regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
synonym: "down-regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
synonym: "downregulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
synonym: "inhibition of ERK1 and ERK2 cascade" NARROW [GOC:mah]
synonym: "negative regulation of ERK cascade" BROAD [GOC:add]
synonym: "negative regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of ERK1 cascade" NARROW [GOC:add]
synonym: "negative regulation of ERK1/2 cascade" EXACT [GOC:add]
synonym: "negative regulation of ERK2 cascade" NARROW [GOC:add]
synonym: "negative regulation of MAPK1 cascade" NARROW [GOC:add]
synonym: "negative regulation of MAPK3 cascade" NARROW [GOC:add]
is_a: GO:0043409 ! negative regulation of MAPKKK cascade
is_a: GO:0070372 ! regulation of ERK1 and ERK2 cascade
relationship: negatively_regulates GO:0070371 ! ERK1 and ERK2 cascade

[Term]
id: GO:0070374
name: positive regulation of ERK1 and ERK2 cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah]
synonym: "activation of ERK1 and ERK2 cascade" NARROW [GOC:mah]
synonym: "positive regulation of ERK cascade" BROAD [GOC:add]
synonym: "positive regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of ERK1 cascade" NARROW [GOC:add]
synonym: "positive regulation of ERK1/2 cascade" EXACT [GOC:add]
synonym: "positive regulation of ERK2 cascade" NARROW [GOC:add]
synonym: "positive regulation of MAPK1 cascade" NARROW [GOC:add]
synonym: "positive regulation of MAPK3 cascade" NARROW [GOC:add]
synonym: "stimulation of ERK1 and ERK2 cascade" NARROW [GOC:mah]
synonym: "up regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
synonym: "up-regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
synonym: "upregulation of ERK1 and ERK2 cascade" EXACT [GOC:mah]
is_a: GO:0043410 ! positive regulation of MAPKKK cascade
is_a: GO:0070372 ! regulation of ERK1 and ERK2 cascade
relationship: positively_regulates GO:0070371 ! ERK1 and ERK2 cascade

[Term]
id: GO:0070375
name: BMK cascade
namespace: biological_process
def: "A cascade of protein kinase activities, culminating in the phosphorylation and activation of big MAP kinase (BMK1/ERK5), which is a type of mitogen-activated protein (MAP) kinase." [GOC:add, ISBN:0896039986, PMID:16376520, PMID:16880823]
synonym: "BMK signaling pathway" EXACT [GOC:mah]
synonym: "BMK signalling pathway" EXACT [GOC:mah]
synonym: "BMK1 cascade" EXACT [GOC:add]
synonym: "ERK5 cascade" EXACT [GOC:add]
synonym: "ERK5 signaling pathway" EXACT [PMID:16376520]
synonym: "MAPK7 cascade" EXACT [GOC:add]
is_a: GO:0000165 ! MAPKKK cascade

[Term]
id: GO:0070376
name: regulation of BMK cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the BMK cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]
synonym: "regulation of BMK signaling pathway" EXACT [GOC:mah]
synonym: "regulation of BMK signalling pathway" EXACT [GOC:mah]
synonym: "regulation of BMK1 cascade" EXACT [GOC:add]
synonym: "regulation of ERK5 cascade" EXACT [GOC:add]
synonym: "regulation of ERK5 signaling pathway" EXACT [PMID:16376520]
synonym: "regulation of MAPK7 cascade" EXACT [GOC:add]
is_a: GO:0043408 ! regulation of MAPKKK cascade
relationship: regulates GO:0070375 ! BMK cascade

[Term]
id: GO:0070377
name: negative regulation of BMK cascade
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the BMK cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986]
synonym: "down regulation of BMK cascade" EXACT [GOC:mah]
synonym: "down-regulation of BMK cascade" EXACT [GOC:mah]
synonym: "downregulation of BMK cascade" EXACT [GOC:mah]
synonym: "inhibition of BMK cascade" NARROW [GOC:mah]
synonym: "negative regulation of BMK signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of BMK signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation of BMK1 cascade" EXACT [GOC:add]
synonym: "negative regulation of ERK5 cascade" EXACT [GOC:add]
synonym: "negative regulation of ERK5 signaling pathway" EXACT [PMID:16376520]
synonym: "negative regulation of MAPK7 cascade" EXACT [GOC:add]
is_a: GO:0043409 ! negative regulation of MAPKKK cascade
is_a: GO:0070376 ! regulation of BMK cascade
relationship: negatively_regulates GO:0070375 ! BMK cascade

[Term]
id: GO:0070378
name: positive regulation of BMK cascade
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the BMK cascade." [GOC:mah]
synonym: "activation of BMK cascade" NARROW [GOC:mah]
synonym: "positive regulation of BMK signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of BMK signalling pathway" EXACT [GOC:mah]
synonym: "positive regulation of BMK1 cascade" EXACT [GOC:add]
synonym: "positive regulation of ERK5 cascade" EXACT [GOC:add]
synonym: "positive regulation of ERK5 signaling pathway" EXACT [PMID:16376520]
synonym: "positive regulation of MAPK7 cascade" EXACT [GOC:add]
synonym: "stimulation of BMK cascade" NARROW [GOC:mah]
synonym: "up regulation of BMK cascade" EXACT [GOC:mah]
synonym: "up-regulation of BMK cascade" EXACT [GOC:mah]
synonym: "upregulation of BMK cascade" EXACT [GOC:mah]
is_a: GO:0043410 ! positive regulation of MAPKKK cascade
is_a: GO:0070376 ! regulation of BMK cascade
relationship: positively_regulates GO:0070375 ! BMK cascade

[Term]
id: GO:0070379
name: high mobility group box 1 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with high mobility group box 1 (HMBGB1)." [GOC:add, PMID:18431461]
synonym: "HMGB1 binding" EXACT [GOC:add]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0070380
name: high mobility group box 1 receptor activity
namespace: molecular_function
def: "Combining with high mobility group box 1 (HMBGB1) to initiate a change in cell activity." [GOC:add, PMID:18431461]
synonym: "HMGB1 receptor activity" EXACT [GOC:add]
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0070379 ! high mobility group box 1 binding

[Term]
id: GO:0070381
name: endosome to plasma membrane transport vesicle
namespace: cellular_component
def: "A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah, PMID:10679016, PMID:12110576]
synonym: "endosome-plasma membrane transport vesicle" EXACT [GOC:mah]
is_a: GO:0070382 ! exocytic vesicle

[Term]
id: GO:0070382
name: exocytic vesicle
namespace: cellular_component
def: "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah]
synonym: "exocytotic vesicle" EXACT [GOC:kad]
is_a: GO:0030133 ! transport vesicle

[Term]
id: GO:0070383
name: DNA cytosine deamination
namespace: biological_process
def: "The removal of an amino group from a cytosine residue in DNA, forming a uracil residue." [GOC:mah]
is_a: GO:0045006 ! DNA deamination

[Term]
id: GO:0070384
name: Harderian gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the Harderian gland over time, from its formation to the mature structure. The Harderian gland is an anterior orbital structure usually associated with the nictitating membrane, and produces and secretes a variety of substances to the eye, depending upon the species." [GOC:hjd, PMID:16856596, PMID:7559104]
comment: Note that the Harderian gland is found in all terrestrial vertebrate groups, including amphibia, reptiles, birds, and mammals. However, it appears to be absent in certain mammals such as bats, cows, horses, and higher primates. Though largely absent in the adult human, it is present in the fetal and neonatal stages.
is_a: GO:0048732 ! gland development

[Term]
id: GO:0070385
name: egasyn-beta-glucuronidase complex
namespace: cellular_component
def: "A protein complex that contains beta-glucuronidase and the carboxyl esterase egasyn; formation of the complex causes beta-glucuronidase to be retained in the endoplasmic reticulum." [PMID:7744842]
is_a: GO:0043234 ! protein complex
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0070386
name: procollagen-proline 4-dioxygenase complex, alpha(I) type
namespace: cellular_component
def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type I isoform; its activity is readily inhibited by poly(L-proline)." [PMID:14500733, PMID:7753822]
synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(I) type" EXACT [PMID:7753822]
synonym: "prolyl 4-hydroxylase complex (alpha(I)-type)" BROAD [CORUM:472]
is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex

[Term]
id: GO:0070387
name: procollagen-proline 4-dioxygenase complex, alpha(II) type
namespace: cellular_component
def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type II isoform; its activity is inhibited by poly(L-proline) only at high concentrations." [PMID:14500733, PMID:7753822]
synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(II) type" EXACT [PMID:7753822]
synonym: "prolyl 4-hydroxylase complex (alpha(II)-type)" BROAD [CORUM:473]
is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex

[Term]
id: GO:0070388
name: procollagen-proline 4-dioxygenase complex, alpha(III) type
namespace: cellular_component
def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type III isoform." [PMID:14500733]
synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(III) type" EXACT [PMID:14500733]
synonym: "prolyl 4-hydroxylase complex (alpha(III)-type)" BROAD [CORUM:474]
is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex

[Term]
id: GO:0070389
name: chaperone cofactor-dependent protein refolding
namespace: biological_process
def: "The process of assisting in the restoration of the biological activity of an unfolded or misfolded protein, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:mah, GOC:rb]
subset: gosubset_prok
synonym: "chaperone co-factor-dependent protein refolding" EXACT []
is_a: GO:0042026 ! protein refolding

[Term]
id: GO:0070390
name: transcription export complex 2
namespace: cellular_component
def: "A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sus1p and Cdc31p." [GOC:df, GOC:mah, PMID:17786152]
synonym: "Sac3-Thp1-Sus1-Cdc31 complex" EXACT [PMID:17786152]
synonym: "TREX-2 complex" EXACT [GOC:df]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070391
name: response to lipoteichoic acid
namespace: biological_process
def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "response to LTA" EXACT [GOC:add]
is_a: GO:0002237 ! response to molecule of bacterial origin

[Term]
id: GO:0070392
name: detection of lipoteichoic acid
namespace: biological_process
def: "The series of events in which a lipoteichoic acid stimulus is received by a cell and converted into a molecular signal; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "detection of LTA" EXACT [GOC:add]
is_a: GO:0032490 ! detection of molecule of bacterial origin
is_a: GO:0070391 ! response to lipoteichoic acid

[Term]
id: GO:0070393
name: teichoic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues." [GOC:add, PMID:14665680]
synonym: "teichoic acid breakdown" EXACT [GOC:add]
synonym: "teichoic acid catabolism" EXACT [GOC:add]
synonym: "teichoic acid degradation" EXACT [GOC:add]
is_a: GO:0000272 ! polysaccharide catabolic process
is_a: GO:0046374 ! teichoic acid metabolic process

[Term]
id: GO:0070394
name: lipoteichoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "lipoteichoic acid metabolism" EXACT [GOC:add]
synonym: "LTA metabolic process" EXACT [GOC:add]
is_a: GO:0046374 ! teichoic acid metabolic process

[Term]
id: GO:0070395
name: lipoteichoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "lipoteichoic acid anabolism" EXACT [GOC:add]
synonym: "lipoteichoic acid biosynthesis" EXACT [GOC:add]
synonym: "lipoteichoic acid formation" EXACT [GOC:add]
synonym: "lipoteichoic acid synthesis" EXACT [GOC:add]
synonym: "LTA biosynthetic process" BROAD [GOC:add]
is_a: GO:0019350 ! teichoic acid biosynthetic process
is_a: GO:0070394 ! lipoteichoic acid metabolic process

[Term]
id: GO:0070396
name: lipoteichoic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680]
synonym: "lipoteichoic acid breakdown" EXACT [GOC:add]
synonym: "lipoteichoic acid catabolism" EXACT [GOC:add]
synonym: "lipoteichoic acid degradation" EXACT [GOC:add]
is_a: GO:0070393 ! teichoic acid catabolic process
is_a: GO:0070394 ! lipoteichoic acid metabolic process

[Term]
id: GO:0070397
name: wall teichoic acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "wall teichoic acid metabolism" EXACT [GOC:add]
synonym: "WTA metabolic process" EXACT [GOC:add]
is_a: GO:0046374 ! teichoic acid metabolic process

[Term]
id: GO:0070398
name: wall teichoic acid biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "wall teichoic acid anabolism" EXACT [GOC:add]
synonym: "wall teichoic acid biosynthesis" EXACT [GOC:add]
synonym: "wall teichoic acid formation" EXACT [GOC:add]
synonym: "wall teichoic acid synthesis" EXACT [GOC:add]
synonym: "WTA biosynthetic process" EXACT [GOC:add]
is_a: GO:0019350 ! teichoic acid biosynthetic process
is_a: GO:0070397 ! wall teichoic acid metabolic process

[Term]
id: GO:0070399
name: wall teichoic acid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680]
synonym: "wall teichoic acid breakdown" EXACT [GOC:add]
synonym: "wall teichoic acid catabolism" EXACT [GOC:add]
synonym: "wall teichoic acid degradation" EXACT [GOC:add]
is_a: GO:0070397 ! wall teichoic acid metabolic process

[Term]
id: GO:0070400
name: teichoic acid D-alanylation
namespace: biological_process
def: "The formation of a D-alanyl ester of teichoic acid. Alanylation of teichoic acids modulates the properties of the bacterial cell wall and modulates the inflammatory properties of the teichoic acid." [GOC:add, PMID:14665680, PMID:16020688]
synonym: "teichoic acid alanylation" EXACT [GOC:add]
is_a: GO:0019350 ! teichoic acid biosynthetic process

[Term]
id: GO:0070401
name: NADP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the oxidized form, NADP, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
synonym: "NADP (oxidized) binding" EXACT [GOC:mah]
synonym: "oxidized NADP binding" EXACT [GOC:mah]
synonym: "oxidized nicotinamide adenine dinucleotide phosphate binding" EXACT [GOC:mah]
is_a: GO:0050661 ! NADP or NADPH binding

[Term]
id: GO:0070402
name: NADPH binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
synonym: "NADP (reduced) binding" EXACT [GOC:mah]
synonym: "reduced NADP binding" EXACT [GOC:mah]
synonym: "reduced nicotinamide adenine dinucleotide phosphate binding" EXACT [GOC:mah]
is_a: GO:0050661 ! NADP or NADPH binding

[Term]
id: GO:0070403
name: NAD binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
synonym: "NAD (oxidized) binding" EXACT [GOC:mah]
synonym: "oxidized NAD binding" EXACT [GOC:mah]
synonym: "oxidized nicotinamide adenine dinucleotide binding" EXACT [GOC:mah]
is_a: GO:0051287 ! NAD or NADH binding

[Term]
id: GO:0070404
name: NADH binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah]
synonym: "NAD (reduced) binding" EXACT [GOC:mah]
synonym: "reduced NAD binding" EXACT [GOC:mah]
synonym: "reduced nicotinamide adenine dinucleotide binding" EXACT [GOC:mah]
is_a: GO:0051287 ! NAD or NADH binding

[Term]
id: GO:0070405
name: ammonium ion binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with ammonium ions (NH4+)." [ChEBI:28938, GOC:ecd]
is_a: GO:0043169 ! cation binding

[Term]
id: GO:0070406
name: glutamine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with glutamine, 2,5-diamino-5-oxopentanoic acid." [ChEBI:28300, GOC:ecd]
is_a: GO:0016597 ! amino acid binding

[Term]
id: GO:0070407
name: oxidation-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the oxidation of one or more amino acid residues in the protein." [GOC:mah]
synonym: "oxidation-dependent protein breakdown" EXACT [GOC:mah]
synonym: "oxidation-dependent protein catabolism" EXACT [GOC:mah]
synonym: "oxidation-dependent protein degradation" EXACT [GOC:mah]
synonym: "oxidation-dependent proteolysis" EXACT [GOC:mah]
synonym: "oxidized protein catabolic process" EXACT [GOC:mah]
is_a: GO:0019941 ! modification-dependent protein catabolic process

[Term]
id: GO:0070408
name: carbamoyl phosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [ChEBI:17672, GOC:mah, GOC:rph]
synonym: "carbamoyl phosphate metabolism" EXACT [GOC:mah]
xref: UM-BBD_pathwayID:bzn
is_a: GO:0034641 ! cellular nitrogen compound metabolic process

[Term]
id: GO:0070409
name: carbamoyl phosphate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [ChEBI:17672, GOC:mah, GOC:rph]
subset: gosubset_prok
synonym: "carbamoyl phosphate anabolism" EXACT []
synonym: "carbamoyl phosphate biosynthesis" EXACT []
synonym: "carbamoyl phosphate formation" EXACT []
synonym: "carbamoyl phosphate synthesis" EXACT []
synonym: "carbamyl phosphate biosynthetic process" EXACT [GOC:rph]
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0070408 ! carbamoyl phosphate metabolic process

[Term]
id: GO:0070410
name: co-SMAD binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a common mediator SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992]
is_a: GO:0046332 ! SMAD binding

[Term]
id: GO:0070411
name: I-SMAD binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992]
is_a: GO:0046332 ! SMAD binding

[Term]
id: GO:0070412
name: R-SMAD binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992]
is_a: GO:0046332 ! SMAD binding

[Term]
id: GO:0070413
name: trehalose metabolism in response to stress
namespace: biological_process
def: "The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress." [GOC:jp, GOC:mah, PMID:9797333]
synonym: "trehalose metabolic process involved in response to stress" EXACT systematic_synonym [GOC:mah]
is_a: GO:0005991 ! trehalose metabolic process
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0070414
name: trehalose metabolism in response to heat stress
namespace: biological_process
def: "The chemical reactions and pathways involving trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:jp, GOC:mah, PMID:9797333]
synonym: "trehalose metabolic process involved in response to heat stress" EXACT systematic_synonym [GOC:mah]
is_a: GO:0034605 ! cellular response to heat
is_a: GO:0070413 ! trehalose metabolism in response to stress

[Term]
id: GO:0070415
name: trehalose metabolism in response to cold stress
namespace: biological_process
def: "The chemical reactions and pathways involving trehalose that occur as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:jp, GOC:mah, PMID:9797333]
synonym: "trehalose metabolic process involved in response to cold stress" EXACT systematic_synonym [GOC:mah]
is_a: GO:0070413 ! trehalose metabolism in response to stress
is_a: GO:0070417 ! cellular response to cold

[Term]
id: GO:0070416
name: trehalose metabolism in response to water deprivation
namespace: biological_process
def: "The chemical reactions and pathways involving trehalose that occur as a result of deprivation of water." [GOC:jp, GOC:mah, PMID:9797333]
synonym: "trehalose metabolic process involved in response to water deprivation" EXACT systematic_synonym [GOC:mah]
is_a: GO:0042631 ! cellular response to water deprivation
is_a: GO:0070413 ! trehalose metabolism in response to stress

[Term]
id: GO:0070417
name: cellular response to cold
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:jp]
synonym: "cellular response to cold stress" EXACT [GOC:jp]
is_a: GO:0009409 ! response to cold
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0070418
name: DNA-dependent protein kinase complex
namespace: cellular_component
def: "A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku." [GOC:mah, PMID:10854421, PMID:12235392]
synonym: "DNA-dependent protein kinase, DNA-end-binding complex" NARROW []
synonym: "DNA-PK complex" EXACT []
synonym: "DNA-PK-Ku antigen complex" EXACT [CORUM:355]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070419
name: nonhomologous end joining complex
namespace: cellular_component
def: "A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends." [GOC:mah, PMID:17072889, PMID:17938628]
synonym: "NHEJ complex" EXACT [GOC:mah]
synonym: "non-homologous end joining complex" EXACT [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0070420
name: Ku-DNA ligase complex
namespace: cellular_component
def: "A nonhomologous end joining complex that contains one or more Ku monomers and one or more DNA ligase molecules from the LigC or LigD family, and mediates nonhomologous end joining in bacteria." [GOC:mah, PMID:17938628]
is_a: GO:0070419 ! nonhomologous end joining complex

[Term]
id: GO:0070421
name: DNA ligase III-XRCC1 complex
namespace: cellular_component
def: "A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair." [PMID:15141024, PMID:7760816]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070422
name: G-protein beta/gamma-Raf-1 complex
namespace: cellular_component
def: "A protein complex formed by the association of the serine-threonine protein kinase Raf-1 with the beta and gamma subunits of a heterotrimeric G protein." [GOC:mah, PMID:7782277]
comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'.
synonym: "G protein complex (GNG2, GNB2L1, RAF1)" RELATED [CORUM:1539]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0070423
name: nucleotide-binding oligomerization domain containing signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to a nucleotide-binding oligomerization domain containing (NOD) protein." [GOC:add, PMID:17944960, PMID:18585455]
synonym: "NOD signaling pathway" EXACT [GOC:add]
synonym: "nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah]
is_a: GO:0002221 ! pattern recognition receptor signaling pathway

[Term]
id: GO:0070424
name: regulation of nucleotide-binding oligomerization domain containing signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add]
synonym: "regulation of NOD signaling pathway" EXACT [GOC:add]
synonym: "regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah]
is_a: GO:0002682 ! regulation of immune system process
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway

[Term]
id: GO:0070425
name: negative regulation of nucleotide-binding oligomerization domain containing signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add]
synonym: "negative regulation of NOD signaling pathway" EXACT [GOC:add]
synonym: "negative regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah]
is_a: GO:0002683 ! negative regulation of immune system process
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway
relationship: negatively_regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway

[Term]
id: GO:0070426
name: positive regulation of nucleotide-binding oligomerization domain containing signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add]
synonym: "positive regulation of NOD signaling pathway" EXACT [GOC:add]
synonym: "positive regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah]
is_a: GO:0002684 ! positive regulation of immune system process
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway
relationship: positively_regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway

[Term]
id: GO:0070427
name: nucleotide-binding oligomerization domain containing 1 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 1 (NOD1)." [GOC:add, PMID:17944960, PMID:18585455]
synonym: "NOD1 signaling pathway" EXACT [GOC:add]
synonym: "nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway

[Term]
id: GO:0070428
name: regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add]
synonym: "regulation of NOD1 signaling pathway" EXACT [GOC:add]
synonym: "regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway
relationship: regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway

[Term]
id: GO:0070429
name: negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add]
synonym: "negative regulation of NOD1 signaling pathway" EXACT [GOC:add]
synonym: "negative regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070425 ! negative regulation of nucleotide-binding oligomerization domain containing signaling pathway
is_a: GO:0070428 ! regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
relationship: negatively_regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway

[Term]
id: GO:0070430
name: positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add]
synonym: "positive regulation of NOD1 signaling pathway" EXACT [GOC:add]
synonym: "positive regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070426 ! positive regulation of nucleotide-binding oligomerization domain containing signaling pathway
is_a: GO:0070428 ! regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
relationship: positively_regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway

[Term]
id: GO:0070431
name: nucleotide-binding oligomerization domain containing 2 signaling pathway
namespace: biological_process
def: "Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 2 (NOD2)." [GOC:add, PMID:17944960, PMID:18585455]
synonym: "NOD2 signaling pathway" EXACT [GOC:add]
synonym: "nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway

[Term]
id: GO:0070432
name: regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add]
synonym: "regulation of NOD2 signaling pathway" EXACT [GOC:add]
synonym: "regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway
relationship: regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway

[Term]
id: GO:0070433
name: negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add]
synonym: "negative regulation of NOD2 signaling pathway" EXACT [GOC:add]
synonym: "negative regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070425 ! negative regulation of nucleotide-binding oligomerization domain containing signaling pathway
is_a: GO:0070432 ! regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
relationship: negatively_regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway

[Term]
id: GO:0070434
name: positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add]
synonym: "positive regulation of NOD2 signaling pathway" EXACT [GOC:add]
synonym: "positive regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah]
is_a: GO:0070426 ! positive regulation of nucleotide-binding oligomerization domain containing signaling pathway
is_a: GO:0070432 ! regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
relationship: positively_regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway

[Term]
id: GO:0070435
name: Shc-EGFR complex
namespace: cellular_component
def: "A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267]
synonym: "Shc-Egfr complex, EGF stimulated" NARROW [CORUM:2887]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070436
name: Grb2-EGFR complex
namespace: cellular_component
def: "A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267]
synonym: "Grb2-Egfr complex, EGF stimulated" NARROW [CORUM:2889]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070437
name: Grb2-Shc complex
namespace: cellular_component
def: "A protein complex that contains Grb2 and the adaptor protein Shc, and is involved in linking epidermal growth factor receptor (EGFR) activation to the p21-Ras pathway." [GOC:mah, PMID:7798267]
synonym: "Grb2-Shc complex, EGF stimulated" NARROW [CORUM:2888]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070438
name: mTOR-FKBP12 complex
namespace: cellular_component
def: "A protein complex that contains the mTOR (mammalian target of rapamycin) serine/threonine kinase and the peptidyl-prolyl cis-trans isomerase FKBP12 (FKBP1A)." [PMID:7822316]
synonym: "Fkbp1a-Frap1 complex" NARROW [CORUM:2987]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0070439
name: Mad-Max-mSin3A complex
namespace: cellular_component
def: "A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3A, a homolog of the yeast Sin3p." [PMID:7889570]
is_a: GO:0017053 ! transcriptional repressor complex

[Term]
id: GO:0070440
name: Mad-Max-mSin3B complex
namespace: cellular_component
def: "A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3B, a homolog of the yeast Sin3p." [PMID:7889570]
is_a: GO:0017053 ! transcriptional repressor complex

[Term]
id: GO:0070441
name: G-protein beta/gamma-Btk complex
namespace: cellular_component
def: "A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein." [GOC:mah, PMID:7972043]
comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'.
synonym: "G protein complex (BTK, GNG1, GNG2)" RELATED [CORUM:1615]
synonym: "G protein complex (Btk, Gng2, Gnb1)" RELATED [CORUM:3195]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0070442
name: alphaIIb-beta3 integrin complex
namespace: cellular_component
def: "An integrin complex that comprises one alphaIIb subunit and one beta3 subunit." [PMID:12297042]
synonym: "ITGA2B-ITGB3 complex" NARROW [CORUM:2381]
is_a: GO:0008305 ! integrin complex

[Term]
id: GO:0070443
name: Mad-Max complex
namespace: cellular_component
def: "A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max." [PMID:8224841]
is_a: GO:0017053 ! transcriptional repressor complex

[Term]
id: GO:0070444
name: oligodendrocyte progenitor proliferation
namespace: biological_process
def: "The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system." [GOC:mah, GOC:sl, PMID:15504915]
synonym: "oligodendrocyte precursor proliferation" EXACT [GOC:mah]
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0042063 ! gliogenesis

[Term]
id: GO:0070445
name: regulation of oligodendrocyte progenitor proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl]
synonym: "regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah]
is_a: GO:0014013 ! regulation of gliogenesis
is_a: GO:0042127 ! regulation of cell proliferation
relationship: regulates GO:0070444 ! oligodendrocyte progenitor proliferation

[Term]
id: GO:0070446
name: negative regulation of oligodendrocyte progenitor proliferation
namespace: biological_process
def: "Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl]
synonym: "negative regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0014014 ! negative regulation of gliogenesis
is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation
relationship: negatively_regulates GO:0070444 ! oligodendrocyte progenitor proliferation

[Term]
id: GO:0070447
name: positive regulation of oligodendrocyte progenitor proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl]
synonym: "positive regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0014015 ! positive regulation of gliogenesis
is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation
relationship: positively_regulates GO:0070444 ! oligodendrocyte progenitor proliferation

[Term]
id: GO:0070448
name: laricitrin 5'-O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin." [MetaCyc:RXN-8452]
comment: Note that this term represents one of two reactions that are grouped together in EC 2.1.1.149.
synonym: "CrCOMT2" RELATED [EC:2.1.1.149]
synonym: "flavonoid 3',5'-O-dimethyltransferase activity" RELATED [EC:2.1.1.149]
synonym: "S-adenosyl-L-methionine:myricetin O-methyltransferase activity" RELATED [EC:2.1.1.149]
xref: EC:2.1.1.149
xref: MetaCyc:RXN-8452
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity

[Term]
id: GO:0070449
name: elongin complex
namespace: cellular_component
def: "A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (abut 100 kDa)and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa)subunits." [PMID:12676794]
comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'.
synonym: "elongin (SIII) complex" EXACT [CORUM:56]
synonym: "transcription elongation factor SIII complex" EXACT [PMID:8244996]
is_a: GO:0008023 ! transcription elongation factor complex

[Term]
id: GO:0070450
name: interleukin4-interleukin-4 receptor complex
namespace: cellular_component
def: "A protein complex that is formed by the association of a heterodimeric interleukin-4 receptor complex with an interleukin-4 molecule." [GOC:mah, PMID:10358772]
subset: goslim_pir
synonym: "IL4-IL4 receptor complex" EXACT [GOC:mah]
synonym: "IL4-IL4R-IL2RG complex" NARROW [CORUM:1515]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070451
name: cell hair
namespace: cellular_component
def: "A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located." [PMID:11526084]
subset: goslim_pir
synonym: "imaginal disc-derived wing hair" NARROW [GOC:mah]
synonym: "non-sensory hair" EXACT [GOC:bf]
xref: Wikipedia:Membrane_nanotube
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0070452
name: positive regulation of ergosterol biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:mah]
synonym: "activation of ergosterol biosynthetic process" NARROW []
synonym: "positive regulation of ergosterol anabolism" EXACT []
synonym: "positive regulation of ergosterol biosynthesis" EXACT []
synonym: "positive regulation of ergosterol formation" EXACT []
synonym: "positive regulation of ergosterol synthesis" EXACT []
synonym: "stimulation of ergosterol biosynthetic process" NARROW []
synonym: "up regulation of ergosterol biosynthetic process" EXACT []
synonym: "up-regulation of ergosterol biosynthetic process" EXACT []
synonym: "upregulation of ergosterol biosynthetic process" EXACT []
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0032443 ! regulation of ergosterol biosynthetic process
relationship: positively_regulates GO:0006696 ! ergosterol biosynthetic process

[Term]
id: GO:0070453
name: regulation of heme biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of haem biosynthesis" EXACT [GOC:mah]
synonym: "regulation of haem biosynthetic process" EXACT [GOC:mah]
synonym: "regulation of heme anabolism" EXACT [GOC:mah]
synonym: "regulation of heme biosynthesis" EXACT [GOC:mah]
synonym: "regulation of heme formation" EXACT [GOC:mah]
synonym: "regulation of heme synthesis" EXACT [GOC:mah]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:0051193 ! regulation of cofactor metabolic process
relationship: regulates GO:0006783 ! heme biosynthetic process

[Term]
id: GO:0070454
name: negative regulation of heme biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah]
synonym: "down regulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "downregulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of heme biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of haem biosynthetic process" EXACT [GOC:mah]
synonym: "negative regulation of heme anabolism" EXACT [GOC:mah]
synonym: "negative regulation of heme biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of heme formation" EXACT [GOC:mah]
synonym: "negative regulation of heme synthesis" EXACT [GOC:mah]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:0051195 ! negative regulation of cofactor metabolic process
is_a: GO:0070453 ! regulation of heme biosynthetic process
relationship: negatively_regulates GO:0006783 ! heme biosynthetic process

[Term]
id: GO:0070455
name: positive regulation of heme biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah]
synonym: "activation of heme biosynthetic process" NARROW [GOC:mah]
synonym: "positive regulation of haem biosynthetic process" EXACT [GOC:mah]
synonym: "positive regulation of heme anabolism" EXACT [GOC:mah]
synonym: "positive regulation of heme biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of heme formation" EXACT [GOC:mah]
synonym: "positive regulation of heme synthesis" EXACT [GOC:mah]
synonym: "stimulation of heme biosynthetic process" NARROW [GOC:mah]
synonym: "up regulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "up-regulation of heme biosynthetic process" EXACT [GOC:mah]
synonym: "upregulation of heme biosynthetic process" EXACT [GOC:mah]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:0051194 ! positive regulation of cofactor metabolic process
is_a: GO:0070453 ! regulation of heme biosynthetic process
relationship: positively_regulates GO:0006783 ! heme biosynthetic process

[Term]
id: GO:0070456
name: galactose-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate." [GOC:mah]
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0070457
name: D-galactose-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: D-galactose-1-phosphate + H2O = D-galactose + phosphate." [GOC:mah, PMID:9462881]
is_a: GO:0070456 ! galactose-1-phosphate phosphatase activity

[Term]
id: GO:0070458
name: cellular detoxification of nitrogen compound
namespace: biological_process
def: "Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:mah]
synonym: "cellular detoxification of nitrogenous compound" EXACT [GOC:mah]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0034641 ! cellular nitrogen compound metabolic process
is_a: GO:0051410 ! detoxification of nitrogen compound
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0070459
name: prolactin secretion
namespace: biological_process
def: "The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0070460
name: thyroid-stimulating hormone secretion
namespace: biological_process
def: "The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "thyroid stimulating hormone secretion" EXACT [GOC:mah]
is_a: GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0070461
name: SAGA-type complex
namespace: cellular_component
def: "A histone acetyltransferase complex that acetylates nucleosomal H3 and H2B and is required for the expression of a subset of Pol II-transcribed genes. The budding yeast complex includes the acetyltransferase Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [GOC:mah, PMID:10637607, PMID:17337012]
synonym: "SAGA family complex" EXACT [PMID:17337012]
is_a: GO:0000123 ! histone acetyltransferase complex

[Term]
id: GO:0070462
name: plus-end specific microtubule depolymerization
namespace: biological_process
def: "The removal of tubulin heterodimers from the plus end of a microtubule." [GOC:krc, PMID:16906145, PMID:16906148]
is_a: GO:0007019 ! microtubule depolymerization

[Term]
id: GO:0070463
name: tubulin-dependent ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, requiring the presence of a tubulin dimer to accelerate release of ADP and phosphate." [GOC:mah, PMID:16906148]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "tubulin-activated ATPase activity" EXACT []
is_a: GO:0042623 ! ATPase activity, coupled

[Term]
id: GO:0070464
name: alphav-beta3 integrin-collagen alpha3(VI) complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the alpha3 chain of type VI collagen; the integrin binds most strongly to unfolded collagen." [PMID:8387021]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070465
name: alpha1-beta1 integrin-alpha3(VI) complex
namespace: cellular_component
def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain." [PMID:8387021]
synonym: "ITGA1-ITGB1-COL6A3 complex" NARROW [CORUM:2434]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070466
name: alpha2-beta1 integrin-alpha3(VI) complex
namespace: cellular_component
def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain." [PMID:8387021]
synonym: "ITGA2-ITGB1-COL6A3 complex" NARROW [CORUM:2431]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070467
name: RC-1 DNA recombination complex
namespace: cellular_component
def: "A protein complex that contains DNA ligase III, DNA polymerase epsilon, a 5'-3' exonuclease, and the SMC1 and SMC2 proteins, and is involved in recombinational repair of deletions and gaps in DNA." [PMID:8392064, PMID:8670910]
synonym: "DNA recombination complex RC-1" EXACT [GOC:mah]
synonym: "RC-1 complex (recombination complex 1)" EXACT [CORUM:364]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070468
name: dentine secretion
namespace: biological_process
def: "The regulated release by odontoblasts of the extracellular matrix constituents, including collagen, that form the basis of dentine." [GOC:mah, http:herkules.oulu.fi/isbn9514270355/html/i259726.html, PMID:12856968]
synonym: "dentin secretion" EXACT [GOC:mah]
synonym: "predentin secretion" EXACT [http:herkules.oulu.fi/isbn9514270355/html/i259726.html]
is_a: GO:0070278 ! extracellular matrix constituent secretion
relationship: part_of GO:0042475 ! odontogenesis of dentine-containing tooth

[Term]
id: GO:0070469
name: respiratory chain
namespace: cellular_component
def: "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684]
synonym: "membrane electron transport chain" EXACT [GOC:mah]
is_a: GO:0044425 ! membrane part

[Term]
id: GO:0070470
name: plasma membrane respiratory chain
namespace: cellular_component
def: "A respiratory chain located in the plasma membrane of a cell; made up of the protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the plasma membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:mah, ISBN:0198547684]
synonym: "plasma membrane electron transport chain" EXACT [GOC:mah]
is_a: GO:0044459 ! plasma membrane part
is_a: GO:0070469 ! respiratory chain

[Term]
id: GO:0070471
name: uterine smooth muscle contraction
namespace: biological_process
def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the uterus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The uterus is a muscular organ of the female mammal for containing and usually for nourishing the young during development prior to birth." [GOC:sl]
synonym: "myometrial contraction" EXACT [GOC:sl]
synonym: "myometrial smooth muscle contraction" EXACT [GOC:sl]
synonym: "myometrium contraction" EXACT [GOC:sl]
is_a: GO:0006939 ! smooth muscle contraction

[Term]
id: GO:0070472
name: regulation of uterine smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators]
synonym: "regulation of myometrial contraction" EXACT [GOC:sl]
synonym: "regulation of myometrial smooth muscle contraction" EXACT [GOC:sl]
synonym: "regulation of myometrium contraction" EXACT [GOC:sl]
is_a: GO:0006940 ! regulation of smooth muscle contraction
relationship: regulates GO:0070471 ! uterine smooth muscle contraction

[Term]
id: GO:0070473
name: negative regulation of uterine smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators]
synonym: "down regulation of uterine smooth muscle contraction" EXACT [GOC:mah]
synonym: "down-regulation of uterine smooth muscle contraction" EXACT [GOC:mah]
synonym: "downregulation of uterine smooth muscle contraction" EXACT [GOC:mah]
synonym: "inhibition of uterine smooth muscle contraction" NARROW [GOC:mah]
synonym: "negative regulation of myometrial contraction" EXACT [GOC:sl]
synonym: "negative regulation of myometrial smooth muscle contraction" EXACT [GOC:sl]
synonym: "negative regulation of myometrium contraction" EXACT [GOC:sl]
synonym: "uterine smooth muscle relaxation" RELATED [GOC:mah]
is_a: GO:0045986 ! negative regulation of smooth muscle contraction
is_a: GO:0070472 ! regulation of uterine smooth muscle contraction
relationship: negatively_regulates GO:0070471 ! uterine smooth muscle contraction

[Term]
id: GO:0070474
name: positive regulation of uterine smooth muscle contraction
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators]
synonym: "activation of uterine smooth muscle contraction" NARROW [GOC:mah]
synonym: "positive regulation of myometrial contraction" EXACT [GOC:sl]
synonym: "positive regulation of myometrial smooth muscle contraction" EXACT [GOC:sl]
synonym: "positive regulation of myometrium contraction" EXACT [GOC:sl]
synonym: "stimulation of uterine smooth muscle contraction" NARROW [GOC:mah]
synonym: "up regulation of uterine smooth muscle contraction" EXACT [GOC:mah]
synonym: "up-regulation of uterine smooth muscle contraction" EXACT [GOC:mah]
synonym: "upregulation of uterine smooth muscle contraction" EXACT [GOC:mah]
is_a: GO:0045987 ! positive regulation of smooth muscle contraction
is_a: GO:0070472 ! regulation of uterine smooth muscle contraction
relationship: positively_regulates GO:0070471 ! uterine smooth muscle contraction

[Term]
id: GO:0070475
name: rRNA base methylation
namespace: biological_process
def: "The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule." [GOC:mah]
is_a: GO:0031167 ! rRNA methylation

[Term]
id: GO:0070476
name: rRNA (guanine-N7)-methylation
namespace: biological_process
def: "The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule." [GOC:mah]
is_a: GO:0070475 ! rRNA base methylation

[Term]
id: GO:0070477
name: endospore core
namespace: cellular_component
def: "An intracellular part that represents the innermost portion of an endospore; the endospore core is dehydrated, enriched in dipicolinic acid and divalent cations, and metabolically inactive." [GOC:mah, PMID:15035041, PMID:18035610]
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0070478
name: nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [PMID:12769863]
synonym: "3'-5' NMD" EXACT [GOC:jp]
synonym: "3'-5' nonsense-mediated decay" EXACT [GOC:jp]
synonym: "3'-5' nonsense-mediated mRNA decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA breakdown, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA catabolism, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA degradation, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
is_a: GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
is_a: GO:0034427 ! nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
is_a: GO:0043928 ! exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay

[Term]
id: GO:0070479
name: nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction." [PMID:18554525]
synonym: "5'-3' NMD" EXACT [GOC:jp]
synonym: "5'-3' nonsense-mediated decay" EXACT [GOC:jp]
synonym: "5'-3' nonsense-mediated mRNA decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA breakdown, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA catabolism, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA degradation, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah]
is_a: GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
is_a: GO:0034428 ! nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3'
is_a: GO:0070480 ! exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay

[Term]
id: GO:0070480
name: exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap." [GOC:jp]
synonym: "exonucleolytic nuclear-transcribed mRNA breakdown involved in deadenylation-independent decay" EXACT [GOC:mah]
synonym: "exonucleolytic nuclear-transcribed mRNA catabolism involved in deadenylation-independent decay" EXACT [GOC:mah]
synonym: "exonucleolytic nuclear-transcribed mRNA degradation involved in deadenylation-independent decay" EXACT [GOC:mah]
is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic
is_a: GO:0031086 ! nuclear-transcribed mRNA catabolic process, deadenylation-independent decay

[Term]
id: GO:0070481
name: nuclear-transcribed mRNA catabolic process, non-stop decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon." [PMID:11910110]
synonym: "non-stop decay" EXACT [GOC:jp]
synonym: "non-stop mRNA decay" EXACT [GOC:jp]
synonym: "nonstop mRNA decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA breakdown, non-stop decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA catabolism, non-stop decay" EXACT [GOC:mah]
synonym: "nuclear-transcribed mRNA degradation, non-stop decay" EXACT [GOC:mah]
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0070482
name: response to oxygen levels
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah]
is_a: GO:0042221 ! response to chemical stimulus

[Term]
id: GO:0070483
name: detection of hypoxia
namespace: biological_process
def: "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:BHF, GOC:mah]
synonym: "detection of reduced oxygen levels" EXACT [GOC:vk]
is_a: GO:0001666 ! response to hypoxia
is_a: GO:0003032 ! detection of oxygen

[Term]
id: GO:0070484
name: dehydro-D-arabinono-1,4-lactone metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one." [ChEBI:17803, GOC:cjk, GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone metabolism" EXACT [GOC:mah]
is_a: GO:0046483 ! heterocycle metabolic process

[Term]
id: GO:0070485
name: dehydro-D-arabinono-1,4-lactone biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one." [ChEBI:17803, GOC:cjk, GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone anabolism" EXACT [GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone biosynthesis" EXACT [GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone formation" EXACT [GOC:mah]
synonym: "dehydro-D-arabinono-1,4-lactone synthesis" EXACT [GOC:mah]
is_a: GO:0018130 ! heterocycle biosynthetic process
is_a: GO:0070484 ! dehydro-D-arabinono-1,4-lactone metabolic process

[Term]
id: GO:0070486
name: leukocyte aggregation
namespace: biological_process
def: "The adhesion of one leukocyte to one or more other leukocytes via adhesion molecules." [GOC:sl, PMID:12972508]
synonym: "immune cell aggregation" EXACT [CL:0000738]
synonym: "leucocyte aggregation" EXACT [CL:0000738, GOC:sl]
synonym: "white blood cell aggregation" EXACT [CL:0000738, GOC:sl]
synonym: "white corpuscle aggregation" EXACT [GOC:sl]
is_a: GO:0007159 ! leukocyte adhesion
is_a: GO:0034109 ! homotypic cell-cell adhesion

[Term]
id: GO:0070487
name: monocyte aggregation
namespace: biological_process
def: "The adhesion of one monocyte to one or more other monocytes via adhesion molecules." [GOC:sl, PMID:12972508]
synonym: "mononuclear phagocyte aggregation" EXACT [GOC:sl]
is_a: GO:0070486 ! leukocyte aggregation

[Term]
id: GO:0070488
name: neutrophil aggregation
namespace: biological_process
def: "The adhesion of one neutrophil to one or more other neutrophils via adhesion molecules." [GOC:sl, PMID:12972508]
synonym: "neutrocyte aggregation" EXACT [CL:0000775, GOC:mah]
synonym: "neutrophil leucocyte aggregation" EXACT [CL:0000775, GOC:mah]
synonym: "neutrophil leukocyte aggregation" EXACT [CL:0000775, GOC:mah]
synonym: "neutrophilic leucocyte aggregation" EXACT [CL:0000775, GOC:mah]
synonym: "neutrophilic leukocyte aggregation" EXACT [CL:0000775, GOC:mah]
is_a: GO:0070486 ! leukocyte aggregation

[Term]
id: GO:0070489
name: T cell aggregation
namespace: biological_process
def: "The adhesion of one T cell to one or more other T cells via adhesion molecules." [GOC:sl, PMID:12972508]
synonym: "T lymphocyte aggregation" EXACT [CL:0000084, GOC:sl]
synonym: "T-cell aggregation" EXACT [CL:0000084, GOC:mah]
synonym: "T-lymphocyte aggregation" EXACT [CL:0000084, GOC:mah]
is_a: GO:0071593 ! lymphocyte aggregation

[Term]
id: GO:0070490
name: protein pupylation
namespace: biological_process
def: "The process by which a Pup protein is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of Pup and the epsilon-amino group of a lysine residue of the target protein." [PMID:18980670]
synonym: "Pup-protein conjugation" EXACT [GOC:mah]
synonym: "pupylation" EXACT [GOC:mah]
is_a: GO:0032446 ! protein modification by small protein conjugation
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0070491
name: transcription repressor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a transcription repressor, any protein whose activity is required to prevent or downregulate transcription." [GOC:mah]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0070492
name: oligosaccharide binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah]
subset: gosubset_prok
is_a: GO:0030246 ! carbohydrate binding

[Term]
id: GO:0070493
name: thrombin receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands." [GOC:mah, PMID:1672265]
synonym: "thrombin receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway

[Term]
id: GO:0070494
name: regulation of thrombin receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a thrombin receptor signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "regulation of thrombin receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
relationship: regulates GO:0070493 ! thrombin receptor signaling pathway

[Term]
id: GO:0070495
name: negative regulation of thrombin receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of thrombin receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "negative regulation of thrombin receptor signalling pathway" RELATED [GOC:mah]
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0070494 ! regulation of thrombin receptor signaling pathway
relationship: negatively_regulates GO:0070493 ! thrombin receptor signaling pathway

[Term]
id: GO:0070496
name: positive regulation of thrombin receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of thrombin receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin receptor binding to one of its physiological ligands." [GOC:mah]
synonym: "positive regulation of thrombin receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0070494 ! regulation of thrombin receptor signaling pathway
relationship: positively_regulates GO:0070493 ! thrombin receptor signaling pathway

[Term]
id: GO:0070497
name: 6-carboxy-5,6,7,8-tetrahydropterin synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydroneopterin triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + PPPi." [GOC:imk, PMID:19231875]
is_a: GO:0003824 ! catalytic activity

[Term]
id: GO:0070498
name: interleukin-1-mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of interleukin-1 binding to a cell surface receptor." [GOC:BHF, GOC:mah]
synonym: "IL-1 alpha-mediated signaling pathway" NARROW [GOC:add]
synonym: "IL-1 beta-mediated signaling pathway" NARROW [GOC:add]
synonym: "IL-1-mediated signaling pathway" EXACT [GOC:mah]
synonym: "interleukin-1 alpha-mediated signaling pathway" NARROW [GOC:add]
synonym: "interleukin-1 beta-mediated signaling pathway" NARROW [GOC:add]
synonym: "interleukin-1-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0070499
name: exosporium assembly
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the formation of an exosporium, the outermost layer of a bacterial endospore." [GOC:mah]
synonym: "exosporium formation" EXACT [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0045229 ! external encapsulating structure organization

[Term]
id: GO:0070500
name: poly-gamma-glutamate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds." [GOC:mah, PMID:16689787]
synonym: "poly-gamma-glutamate metabolism" EXACT [GOC:mah]
is_a: GO:0044260 ! cellular macromolecule metabolic process

[Term]
id: GO:0070501
name: poly-gamma-glutamate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds." [GOC:mah, PMID:16689787]
synonym: "poly-gamma-glutamate anabolism" EXACT [GOC:mah]
synonym: "poly-gamma-glutamate biosynthesis" EXACT [GOC:mah]
synonym: "poly-gamma-glutamate formation" EXACT [GOC:mah]
synonym: "poly-gamma-glutamate synthesis" EXACT [GOC:mah]
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
is_a: GO:0070500 ! poly-gamma-glutamate metabolic process

[Term]
id: GO:0070502
name: capsule poly-gamma-glutamate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds, that forms all or part of a bacterial capsule." [GOC:mah, PMID:16689787]
synonym: "capsular poly-gamma-glutamate biosynthetic process" EXACT [GOC:mah]
synonym: "capsule poly-gamma-glutamate anabolism" EXACT [GOC:mah]
synonym: "capsule poly-gamma-glutamate biosynthesis" EXACT [GOC:mah]
synonym: "capsule poly-gamma-glutamate formation" EXACT [GOC:mah]
synonym: "capsule poly-gamma-glutamate synthesis" EXACT [GOC:mah]
is_a: GO:0045230 ! capsule organization
is_a: GO:0070501 ! poly-gamma-glutamate biosynthetic process

[Term]
id: GO:0070503
name: selenium-containing prosthetic group metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments." [GOC:dh, GOC:mah]
synonym: "selenium-containing prosthetic group metabolism" EXACT [GOC:mah]
is_a: GO:0001887 ! selenium metabolic process
is_a: GO:0051189 ! prosthetic group metabolic process

[Term]
id: GO:0070504
name: selenium-containing prosthetic group biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments." [GOC:dh, GOC:mah]
synonym: "selenium-containing prosthetic group anabolism" EXACT [GOC:mah]
synonym: "selenium-containing prosthetic group biosynthesis" EXACT [GOC:mah]
synonym: "selenium-containing prosthetic group formation" EXACT [GOC:mah]
synonym: "selenium-containing prosthetic group synthesis" EXACT [GOC:mah]
is_a: GO:0051191 ! prosthetic group biosynthetic process
is_a: GO:0070503 ! selenium-containing prosthetic group metabolic process

[Term]
id: GO:0070505
name: pollen coat
namespace: cellular_component
def: "A layer of extracellular matrix deposited onto the surface of the pollen wall upon disintegration of the tapetal layer of the anther wall in the late stages of pollen development. The composition of this material is highly heterogeneous and includes waxes, lipid droplets, small aromatic molecules, and proteins. The pollen coat is proposed to have many functions, such as holding pollen in the anther until dispersal, facilitation of pollen dispersal, protection of pollen from water loss and UV radiation, and facilitation of adhesion of pollen to the stigma." [GOC:mah, GOC:rph, PMID:12930826, PMID:15012271]
synonym: "pollenkitt" EXACT [PMID:15012271]
synonym: "tryphine" EXACT [PMID:15012271]
is_a: GO:0044420 ! extracellular matrix part

[Term]
id: GO:0070506
name: high-density lipoprotein receptor activity
namespace: molecular_function
def: "Combining with a high-density lipoprotein to initiate a change in cell activity." [GOC:BHF, GOC:rl]
synonym: "HDL receptor" EXACT [GOC:rl]
xref: Wikipedia:LDL_receptor
is_a: GO:0008035 ! high-density lipoprotein binding
is_a: GO:0030228 ! lipoprotein receptor activity

[Term]
id: GO:0070507
name: regulation of microtubule cytoskeleton organization
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah]
synonym: "regulation of microtubule cytoskeleton organisation" EXACT [GOC:mah]
synonym: "regulation of microtubule dynamics" EXACT [GOC:dph, GOC:tb]
is_a: GO:0032886 ! regulation of microtubule-based process
is_a: GO:0051493 ! regulation of cytoskeleton organization
relationship: regulates GO:0000226 ! microtubule cytoskeleton organization

[Term]
id: GO:0070508
name: cholesterol import
namespace: biological_process
def: "The directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:rl]
synonym: "cholesterol uptake" EXACT [GOC:rl]
is_a: GO:0030301 ! cholesterol transport

[Term]
id: GO:0070509
name: calcium ion import
namespace: biological_process
def: "The directed movement of calcium ions into a cell or organelle." [GOC:mah]
synonym: "calcium ion uptake" EXACT [GOC:mah]
is_a: GO:0070588 ! calcium ion transmembrane transport

[Term]
id: GO:0070510
name: regulation of histone H4-K20 methylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah]
is_a: GO:0031060 ! regulation of histone methylation
relationship: regulates GO:0034770 ! histone H4-K20 methylation

[Term]
id: GO:0070511
name: negative regulation of histone H4-K20 methylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah]
synonym: "down regulation of histone H4-K20 methylation" EXACT [GOC:mah]
synonym: "down-regulation of histone H4-K20 methylation" EXACT [GOC:mah]
synonym: "downregulation of histone H4-K20 methylation" EXACT [GOC:mah]
synonym: "inhibition of histone H4-K20 methylation" NARROW [GOC:mah]
is_a: GO:0031061 ! negative regulation of histone methylation
is_a: GO:0070510 ! regulation of histone H4-K20 methylation
relationship: negatively_regulates GO:0034770 ! histone H4-K20 methylation

[Term]
id: GO:0070512
name: positive regulation of histone H4-K20 methylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah]
synonym: "activation of histone H4-K20 methylation" NARROW [GOC:mah]
synonym: "stimulation of histone H4-K20 methylation" NARROW [GOC:mah]
synonym: "up regulation of histone H4-K20 methylation" EXACT [GOC:mah]
synonym: "up-regulation of histone H4-K20 methylation" EXACT [GOC:mah]
synonym: "upregulation of histone H4-K20 methylation" EXACT [GOC:mah]
is_a: GO:0031062 ! positive regulation of histone methylation
is_a: GO:0070510 ! regulation of histone H4-K20 methylation
relationship: positively_regulates GO:0034770 ! histone H4-K20 methylation

[Term]
id: GO:0070513
name: death domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070514
name: SRF-myogenin-E12 complex
namespace: cellular_component
def: "A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes." [PMID:8617811]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0070515
name: alphaIIb-beta3 integrin-talin complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to talin." [PMID:8663236]
synonym: "ITGA2b-ITGB3-TLN1 complex" NARROW [CORUM:2378]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070516
name: CAK-ERCC2 complex
namespace: cellular_component
def: "A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2." [PMID:8692841, PMID:8692842]
synonym: "cyclin-dependent protein kinase activating kinase holoenzyme-ERCC2 complex" EXACT [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070517
name: DNA replication factor C core complex
namespace: cellular_component
def: "A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37." [PMID:8692848, PMID:9228079, PMID:9582326]
subset: goslim_pir
synonym: "RFC core complex" EXACT [CORUM:278]
is_a: GO:0043234 ! protein complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0043599 ! nuclear DNA replication factor C complex

[Term]
id: GO:0070518
name: alpha4-beta1 integrin-CD53 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family." [PMID:8757325]
synonym: "ITGA4-ITGB1-CD53 complex" NARROW [CORUM:2420]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070519
name: alpha4-beta1 integrin-CD63 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family." [PMID:8757325]
synonym: "ITGA4-ITGB1-CD63 complex" NARROW [CORUM:2424]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070520
name: alpha4-beta1 integrin-CD81 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD81, a member of the tetraspan family." [PMID:10229664, PMID:8757325]
synonym: "ITGA4-ITGB1-CD81 complex" NARROW [CORUM:2419]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070521
name: alpha4-beta1 integrin-CD82 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD82, a member of the tetraspan family." [PMID:8757325]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070522
name: ERCC4-ERCC1 complex
namespace: cellular_component
def: "A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae." [PMID:14734547]
comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex.
synonym: "Rad1-Rad10 complex" EXACT [GOC:mah]
synonym: "XPF-ERCC1 complex" EXACT [PMID:14734547]
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0070523
name: 11-beta-hydroxysteroid dehydrogenase (NAD+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+." [PMID:15761036]
is_a: GO:0003845 ! 11-beta-hydroxysteroid dehydrogenase activity

[Term]
id: GO:0070524
name: 11-beta-hydroxysteroid dehydrogenase (NADP+) activity
namespace: molecular_function
def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [EC:1.1.1.146]
synonym: "11beta-hydroxysteroid:NADP+ 11-oxidoreductase" EXACT [EC:1.1.1.146]
synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146]
synonym: "corticosteroid 11-beta-dehydrogenase activity" EXACT [EC:1.1.1.146]
xref: EC:1.1.1.146
xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN
is_a: GO:0003845 ! 11-beta-hydroxysteroid dehydrogenase activity

[Term]
id: GO:0070525
name: threonylcarbamoyladenosine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [GOC:imk, GOC:mah, PMID:19287007]
synonym: "t6A metabolic process" EXACT [PMID:19287007]
synonym: "t6A metabolism" EXACT [PMID:19287007]
synonym: "threonylcarbamoyladenosine metabolism" EXACT [GOC:MAH]
is_a: GO:0046085 ! adenosine metabolic process

[Term]
id: GO:0070526
name: threonylcarbamoyladenosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [GOC:imk, GOC:mah, PMID:19287007]
synonym: "t6A biosynthesis" EXACT [PMID:19287007]
synonym: "t6A biosynthetic process" EXACT [PMID:19287007]
synonym: "threonylcarbamoyladenosine anabolism" EXACT [GOC:mah]
synonym: "threonylcarbamoyladenosine biosynthesis" EXACT [GOC:mah]
synonym: "threonylcarbamoyladenosine formation" EXACT [GOC:mah]
synonym: "threonylcarbamoyladenosine synthesis" EXACT [GOC:mah]
is_a: GO:0006400 ! tRNA modification
is_a: GO:0070525 ! threonylcarbamoyladenosine metabolic process

[Term]
id: GO:0070527
name: platelet aggregation
namespace: biological_process
def: "The adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF, GOC:vk]
synonym: "blood platelet aggregation" EXACT [CL:0000233]
synonym: "thrombocyte aggregation" RELATED [CL:0000233]
is_a: GO:0034109 ! homotypic cell-cell adhesion
relationship: part_of GO:0030168 ! platelet activation

[Term]
id: GO:0070528
name: protein kinase C signaling cascade
namespace: biological_process
def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:mah]
synonym: "PKC signaling cascade" EXACT [GOC:mah]
synonym: "protein kinase C signalling cascade" EXACT [GOC:mah]
is_a: GO:0007243 ! protein kinase cascade

[Term]
id: GO:0070529
name: L-tryptophan aminotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid." [GOC:mah]
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0070530
name: K63-linked polyubiquitin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers." [GOC:mah, PMID:15556404, PMID:17525341]
is_a: GO:0031593 ! polyubiquitin binding

[Term]
id: GO:0070531
name: BRCA1-A complex
namespace: cellular_component
def: "A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites." [GOC:mah, PMID:19261749]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070532
name: BRCA1-B complex
namespace: cellular_component
def: "A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites." [GOC:mah, PMID:16391231]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070533
name: BRCA1-C complex
namespace: cellular_component
def: "A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint." [GOC:mah, PMID:15485915, PMID:16391231]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070534
name: protein K63-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404]
is_a: GO:0016567 ! protein ubiquitination

[Term]
id: GO:0070535
name: histone H2A K63-linked ubiquitination
namespace: biological_process
def: "A histone ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a lysine residue in histone H2A or the variant H2AX." [GOC:mah, PMID:18430235]
is_a: GO:0033522 ! histone H2A ubiquitination
is_a: GO:0070534 ! protein K63-linked ubiquitination

[Term]
id: GO:0070536
name: protein K63-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193]
is_a: GO:0016579 ! protein deubiquitination

[Term]
id: GO:0070537
name: histone H2A K63-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a lysine residue in histone H2A or the variant H2AX." [GOC:mah, PMID:19202061, PMID:19214193]
is_a: GO:0016578 ! histone deubiquitination
is_a: GO:0070536 ! protein K63-linked deubiquitination

[Term]
id: GO:0070538
name: oleic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid." [ChEBI:16196, GOC:lp, GOC:mah]
is_a: GO:0005504 ! fatty acid binding

[Term]
id: GO:0070539
name: linoleic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid." [ChEBI:17351, GOC:lp, GOC:mah]
is_a: GO:0005504 ! fatty acid binding

[Term]
id: GO:0070540
name: stearic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with stearic acid, the 18-carbon saturated fatty acid octadecanoic acid." [ChEBI:28842, GOC:lp, GOC:mah]
is_a: GO:0005504 ! fatty acid binding

[Term]
id: GO:0070541
name: response to platinum ion
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus." [GOC:sl]
synonym: "response to platinum" EXACT [GOc:mah]
is_a: GO:0010038 ! response to metal ion

[Term]
id: GO:0070542
name: response to fatty acid
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [ChEBI:35366, GOC:lp]
is_a: GO:0033993 ! response to lipid

[Term]
id: GO:0070543
name: response to linoleic acid
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus." [ChEBI:17351, GOC:lp]
synonym: "response to linoleate" EXACT [GOC:mah]
is_a: GO:0070542 ! response to fatty acid

[Term]
id: GO:0070544
name: histone H3-K36 demethylation
namespace: biological_process
def: "The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone." [GOC:sart, PMID:19061644]
synonym: "H3K36 demethylation" RELATED []
is_a: GO:0070076 ! histone lysine demethylation

[Term]
id: GO:0070545
name: PeBoW complex
namespace: cellular_component
def: "A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively." [GOC:ab, GOC:mah, PMID:16043514, PMID:17353269]
is_a: GO:0043234 ! protein complex
is_a: GO:0044452 ! nucleolar part
relationship: part_of GO:0030686 ! 90S preribosome

[Term]
id: GO:0070546
name: L-phenylalanine aminotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid." [GOC:mah]
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0070547
name: L-tyrosine aminotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid." [GOC:mah]
subset: gosubset_prok
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0070548
name: L-glutamine aminotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid." [GOC:mah]
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0070549
name: negative regulation of translation involved in RNA interference
namespace: biological_process
def: "A process of negative regulation of translation that is mediated by the association of small interfering RNAs (siRNAs) with a cognate target mRNA." [GOC:mah, PMID:18771919]
synonym: "down regulation of translation involved in RNA interference" EXACT [GOC:mah]
synonym: "down-regulation of translation involved in RNA interference" EXACT [GOC:mah]
synonym: "downregulation of translation involved in RNA interference" EXACT [GOC:mah]
synonym: "inhibition of translation involved in RNA interference" NARROW [GOC:mah]
synonym: "RNA interference, negative regulation of translation" EXACT [GOC:mah]
is_a: GO:0040033 ! negative regulation of translation, ncRNA-mediated
relationship: part_of GO:0016246 ! RNA interference

[Term]
id: GO:0070550
name: rDNA condensation
namespace: biological_process
def: "The cell cycle process whereby the chromatin structure of the rDNA repeats is compacted. In S. cerevisiae, condensation and resolution of the rDNA occurs during anaphase." [GOC:df, PMID:10811823, PMID:15137940]
is_a: GO:0007076 ! mitotic chromosome condensation

[Term]
id: GO:0070551
name: endoribonuclease activity, cleaving siRNA-paired mRNA
namespace: molecular_function
def: "Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters." [GOC:mah, PMID:15105377]
synonym: "argonaute endoribonuclease activity" RELATED [GOC:mah]
is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters

[Term]
id: GO:0070552
name: BRISC complex
namespace: cellular_component
def: "A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070553
name: nicotinic acid receptor activity
namespace: molecular_function
def: "Combining with nicotinic acid to initiate a change in cell activity." [ChEBI:15940, GOC:mah, PMID:12522134]
synonym: "niacin receptor activity" EXACT [ChEBI:15940, GOC:mah]
is_a: GO:0004930 ! G-protein coupled receptor activity

[Term]
id: GO:0070554
name: synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex
namespace: cellular_component
def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 3, and a complexin (or orthologs thereof)." [PMID:8824312]
synonym: "SNARE complex (Stx3, Snap25, Vamp2, Cplx1)" NARROW [CORUM:842]
synonym: "Stx3-Snap25-Vamp2-Cplx1 complex" NARROW [CORUM:842]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070555
name: response to interleukin-1
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus." [GOC:BHF, GOC:mah]
synonym: "response to IL-1" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine stimulus

[Term]
id: GO:0070556
name: TAF4B-containing transcription factor TFIID complex
namespace: cellular_component
def: "A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4." [GOC:mah, PMID:8858156]
synonym: "TFIID complex, B-cell specific" RELATED [CORUM:485]
is_a: GO:0005669 ! transcription factor TFIID complex

[Term]
id: GO:0070557
name: PCNA-p21 complex
namespace: cellular_component
def: "A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication." [GOC:mah, PMID:7911228, PMID:7915843]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070558
name: alphaM-beta2 integrin-CD63 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaM-beta2 integrin complex bound to membrane protein CD63, a member of the tetraspan family." [PMID:8871662]
synonym: "ITGAM-ITGB2-CD63 complex" NARROW [CORUM:2153]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070559
name: lysosomal multienzyme complex
namespace: cellular_component
def: "A protein complex found in the lysosome that contains beta-galactosidase, cathepsin A, alpha-neuraminidase and N-acetylgalactosamine-6-sulfate sulfatase, and is involved in glycosaminoglycan catabolism." [GOC:mah, PMID:8910459]
synonym: "GALNS-lysosomal hydrolase 1.27 MDa complex" NARROW [CORUM:1379]
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0005764 ! lysosome

[Term]
id: GO:0070560
name: protein secretion by platelet
namespace: biological_process
def: "The regulated release of proteins by a platelet or group of platelets." [GOC:BHF, GOC:mah]
is_a: GO:0009306 ! protein secretion
relationship: part_of GO:0002576 ! platelet degranulation

[Term]
id: GO:0070561
name: vitamin D receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah, PMID:12637589]
synonym: "VDR signaling pathway" EXACT [PMID:12637589]
synonym: "vitamin D receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0030522 ! intracellular receptor-mediated signaling pathway
is_a: GO:0071305 ! cellular response to vitamin D

[Term]
id: GO:0070562
name: regulation of vitamin D receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah]
synonym: "regulation of VDR signaling pathway" EXACT [PMID:12637589]
synonym: "regulation of vitamin D receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0032107 ! regulation of response to nutrient levels
relationship: regulates GO:0070561 ! vitamin D receptor signaling pathway

[Term]
id: GO:0070563
name: negative regulation of vitamin D receptor signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah]
synonym: "down regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
synonym: "down-regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
synonym: "downregulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
synonym: "inhibition of vitamin D receptor signaling pathway" NARROW [GOC:mah]
synonym: "negative regulation of VDR signaling pathway" EXACT [GOC:mah]
synonym: "negative regulation of VDR signalling pathway" EXACT [GOC:mah]
synonym: "negative regulation vitamin D receptor signalling pathway" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0032108 ! negative regulation of response to nutrient levels
is_a: GO:0070562 ! regulation of vitamin D receptor signaling pathway
relationship: negatively_regulates GO:0070561 ! vitamin D receptor signaling pathway

[Term]
id: GO:0070564
name: positive regulation of vitamin D receptor signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah]
synonym: "activation of vitamin D receptor signaling pathway" NARROW [GOC:mah]
synonym: "positive regulation of VDR signaling pathway" EXACT [GOC:mah]
synonym: "positive regulation of vitamin D receptor signalling pathway" EXACT [GOC:mah]
synonym: "stimulation of vitamin D receptor signaling pathway" NARROW [GOC:mah]
synonym: "up regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
synonym: "up-regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
synonym: "upregulation of vitamin D receptor signaling pathway" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0032109 ! positive regulation of response to nutrient levels
is_a: GO:0070562 ! regulation of vitamin D receptor signaling pathway
relationship: positively_regulates GO:0070561 ! vitamin D receptor signaling pathway

[Term]
id: GO:0070565
name: telomere-telomerase complex
namespace: cellular_component
def: "A complex of DNA and protein located at the end of a linear chromosome that enables replication of the telomeric repeat sequences at the end of a linear chromosome." [GOC:pde, PMID:19179534]
comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome.
subset: goslim_pir
subset: gosubset_prok
is_a: GO:0032993 ! protein-DNA complex
is_a: GO:0044427 ! chromosomal part
relationship: part_of GO:0000781 ! chromosome, telomeric region

[Term]
id: GO:0070566
name: adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an adenylyl group to an acceptor." [GOC:mah]
subset: gosubset_prok
xref: MetaCyc:GSADENYLATION-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0070567
name: cytidylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a cytidylyl group to an acceptor." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0070568
name: guanylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a guanylyl group to an acceptor." [GOC:mah]
subset: gosubset_prok
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0070569
name: uridylyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of an uridylyl group to an acceptor." [GOC:mah]
subset: gosubset_prok
xref: MetaCyc:URITRANS-RXN
is_a: GO:0016779 ! nucleotidyltransferase activity

[Term]
id: GO:0070570
name: regulation of neuron projection regeneration
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah]
is_a: GO:0010975 ! regulation of neuron projection development
is_a: GO:0022604 ! regulation of cell morphogenesis
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: regulates GO:0031102 ! neuron projection regeneration

[Term]
id: GO:0070571
name: negative regulation of neuron projection regeneration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah]
is_a: GO:0010977 ! negative regulation of neuron projection development
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0070570 ! regulation of neuron projection regeneration
relationship: negatively_regulates GO:0031102 ! neuron projection regeneration

[Term]
id: GO:0070572
name: positive regulation of neuron projection regeneration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah]
is_a: GO:0010976 ! positive regulation of neuron projection development
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0070570 ! regulation of neuron projection regeneration
relationship: positively_regulates GO:0031102 ! neuron projection regeneration

[Term]
id: GO:0070573
name: metallodipeptidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE]
synonym: "metallo-exo-dipeptidase activity" EXACT [GOC:rb]
synonym: "metalloexodipeptidase activity" EXACT [GOC:mah]
is_a: GO:0008235 ! metalloexopeptidase activity
is_a: GO:0016805 ! dipeptidase activity

[Term]
id: GO:0070574
name: cadmium ion transmembrane transport
namespace: biological_process
def: "A process whereby a cadmium ion is transported from one side of a membrane to the other." [GOC:mah]
subset: gosubset_prok
synonym: "transmembrane cadmium transport" EXACT [GOC:mah]
is_a: GO:0015691 ! cadmium ion transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0070575
name: peptide mating pheromone maturation involved in pheromone-induced unidirectional conjugation
namespace: biological_process
def: "The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of pheromone-induced unidirectional conjugation." [GOC:mah]
synonym: "peptide mating pheromone formation involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah]
synonym: "peptide mating pheromone processing involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah]
is_a: GO:0000762 ! pheromone-induced unidirectional conjugation
is_a: GO:0007323 ! peptide pheromone maturation

[Term]
id: GO:0070576
name: vitamin D 24-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:mah, PMID:15546903]
synonym: "calciferol 24-hydroxylase activity" NARROW [GOC:rl]
synonym: "cholecalciferol 24-hydroxylase activity" NARROW [GOC:rl]
synonym: "ergocalciferol 24-hydroxylase activity" NARROW [GOC:rl]
synonym: "vitamin D2 24-hydroxylase activity" NARROW [GOC:rl]
synonym: "vitamin D3 24-hydroxylase activity" NARROW [GOC:rl]
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0070577
name: histone acetyl-lysine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an acetylated lysine residue within a histone." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821]
synonym: "acetylated histone residue binding" BROAD [GOC:rl]
is_a: GO:0042393 ! histone binding

[Term]
id: GO:0070578
name: RISC-loading complex
namespace: cellular_component
def: "A trimeric ribonucleoprotein complex that and is required for the formation of a mature RNA induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1) and TRBP (TARBP2) in association with the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP." [GOC:ab, PMID:18178619]
synonym: "microRNA loading complex" EXACT [GOC:ab]
synonym: "miRLC" EXACT [GOC:ab]
synonym: "RLC" RELATED [GOC:ab, GOC:mah]
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0070579
name: methylcytosine dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2." [PMID:19372391]
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
is_a: GO:0051213 ! dioxygenase activity

[Term]
id: GO:0070580
name: base J metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J." [PMID:19114062]
synonym: "base J metabolism" EXACT [GOC:mah]
synonym: "beta-D-glucosyl-HOMedU metabolic process" EXACT [GOC:mah]
synonym: "beta-D-glucosyl-hydroxymethyluracil metabolism" EXACT [PMID:19114062]
is_a: GO:0006206 ! pyrimidine base metabolic process

[Term]
id: GO:0070581
name: rolling circle DNA replication
namespace: biological_process
def: "A DNA-dependent DNA replication process in which a single-stranded DNA molecule is synthesized from a circular duplex template. Replication typically does not cease when one circumference has been replicated, but continues around the circumference several more times, producing a long single strand comprising multimers of the replicon." [GOC:cb, GOC:mah, ISBN:0198506732]
synonym: "rolling circle replication" EXACT [GOC:cb]
is_a: GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0070582
name: theta DNA replication
namespace: biological_process
def: "A DNA-dependent DNA replication process in which a double-stranded DNA molecule is synthesized from a circular duplex template." [GOC:cb, GOC:mah, ISBN:0198506732]
synonym: "theta replication" EXACT [GOC:cb]
is_a: GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0070583
name: spore membrane bending pathway
namespace: biological_process
def: "The process by which a bending force is generated in the prospore membrane to form the characteristic curved shape of the prospore." [GOC:df, PMID:18756268]
synonym: "ascospore-type prospore membrane bending" EXACT [GOC:mah]
synonym: "forespore membrane bending" EXACT [GOC:mah]
synonym: "FSM bending" EXACT [GOC:mah]
is_a: GO:0016044 ! cellular membrane organization
relationship: part_of GO:0032120 ! ascospore-type prospore membrane assembly

[Term]
id: GO:0070584
name: mitochondrion morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a mitochondrion are generated and organized. Morphogenesis pertains to the creation of form." [GOC:mah]
comment: This term was added by GO_REF:0000021.
is_a: GO:0007005 ! mitochondrion organization
is_a: GO:0032990 ! cell part morphogenesis

[Term]
id: GO:0070585
name: protein localization in mitochondrion
namespace: biological_process
def: "A process by which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd]
synonym: "protein localization to mitochondrion" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization in organelle

[Term]
id: GO:0070586
name: cell-cell adhesion involved in gastrulation
namespace: biological_process
def: "The attachment of one cell to another cell affecting gastrulation." [GOC:dsf, PMID:19091770]
comment: This term was added by GO_REF:0000021.
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0007369 ! gastrulation

[Term]
id: GO:0070587
name: regulation of cell-cell adhesion involved in gastrulation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of attachment of a cell to another cell affecting gastrulation." [GOC:dsf, PMID:19091770]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0022407 ! regulation of cell-cell adhesion
relationship: regulates GO:0070586 ! cell-cell adhesion involved in gastrulation

[Term]
id: GO:0070588
name: calcium ion transmembrane transport
namespace: biological_process
def: "A process whereby a calcium ion is transported from one side of a membrane to the other." [GOC:mah]
subset: gosubset_prok
synonym: "transmembrane calcium transport" EXACT [GOC:mah]
is_a: GO:0006816 ! calcium ion transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0070589
name: cellular component macromolecule biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a macromolecule that is destined to form part of a specific cellular component." [GOC:mah]
synonym: "cellular component macromolecule biosynthesis" EXACT [GOC:mah]
is_a: GO:0034645 ! cellular macromolecule biosynthetic process
relationship: part_of GO:0044085 ! cellular component biogenesis

[Term]
id: GO:0070590
name: spore wall biogenesis
namespace: biological_process
def: "The process by which a spore wall is synthesized, aggregates, and bonds together. A spore wall is the specialized cell wall lying outside the cell membrane of a spore." [GOC:mah]
is_a: GO:0042546 ! cell wall biogenesis
relationship: part_of GO:0030435 ! sporulation resulting in formation of a cellular spore

[Term]
id: GO:0070591
name: ascospore wall biogenesis
namespace: biological_process
def: "The process by which an ascospore wall is synthesized, aggregates, and bonds together." [GOC:mah]
is_a: GO:0009272 ! fungal-type cell wall biogenesis
is_a: GO:0070590 ! spore wall biogenesis
relationship: part_of GO:0030437 ! ascospore formation

[Term]
id: GO:0070592
name: cell wall polysaccharide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a polysaccharide destined to form part of a cell wall." [GOC:mah]
subset: gosubset_prok
synonym: "cell wall polysaccharide anabolism" EXACT [GOC:mah]
synonym: "cell wall polysaccharide biosynthesis" EXACT [GOC:mah]
synonym: "cell wall polysaccharide synthesis" EXACT [GOC:mah]
is_a: GO:0010383 ! cell wall polysaccharide metabolic process
is_a: GO:0033692 ! cellular polysaccharide biosynthetic process
is_a: GO:0044038 ! cell wall macromolecule biosynthetic process

[Term]
id: GO:0070593
name: dendrite self-avoidance
namespace: biological_process
def: "The process by which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551]
synonym: "dendrite repulsion" EXACT [GOC:sart]
is_a: GO:0008038 ! neuron recognition

[Term]
id: GO:0070594
name: juvenile hormone response element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone." [GOC:sart, PMID:17956872]
synonym: "JHRE binding" EXACT [GOC:mah]
is_a: GO:0010843 ! promoter binding

[Term]
id: GO:0070595
name: 1,3-alpha-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-1,3 glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds." [GOC:mah]
synonym: "1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0030978 ! alpha-glucan metabolic process

[Term]
id: GO:0070596
name: 1,3-alpha-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alpha-1,3 glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds." [GOC:mah]
synonym: "1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan anabolism" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan biosynthesis" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan biosynthetic process" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan formation" EXACT [GOC:mah]
synonym: "alpha-1,3 glucan synthesis" EXACT [GOC:mah]
is_a: GO:0030979 ! alpha-glucan biosynthetic process
is_a: GO:0070595 ! 1,3-alpha-glucan metabolic process

[Term]
id: GO:0070597
name: cell wall 1,3-alpha-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-1,3 glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0070595 ! 1,3-alpha-glucan metabolic process

[Term]
id: GO:0070598
name: cell wall 1,3-alpha-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1,3-alpha-glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3-glucan formation" EXACT [GOC:mah]
synonym: "cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process
is_a: GO:0070596 ! 1,3-alpha-glucan biosynthetic process
is_a: GO:0070597 ! cell wall 1,3-alpha-glucan metabolic process

[Term]
id: GO:0070599
name: fungal-type cell wall 1,3-alpha-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-1,3 glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "ascospore wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "ascospore wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "ascospore wall alpha-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0070597 ! cell wall 1,3-alpha-glucan metabolic process

[Term]
id: GO:0070600
name: fungal-type cell wall 1,3-alpha-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1,3-alpha-glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "fungal-type cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "fungal-type cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah]
synonym: "fungal-type cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "fungal-type cell wall alpha-1,3-glucan formation" EXACT [GOC:mah]
synonym: "fungal-type cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0070598 ! cell wall 1,3-alpha-glucan biosynthetic process
is_a: GO:0070599 ! fungal-type cell wall 1,3-alpha-glucan metabolic process

[Term]
id: GO:0070601
name: centromeric sister chromatid cohesion
namespace: biological_process
def: "The cell cycle process by which the sister chromatids of a replicated chromosome are joined along the length of the centromeric region of the chromosome." [GOC:mah]
synonym: "sister chromatid cohesion at centromere" EXACT [GOC:mah]
is_a: GO:0007062 ! sister chromatid cohesion

[Term]
id: GO:0070602
name: regulation of centromeric sister chromatid cohesion
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sister chromatid cohesion in the centromeric region of a chromosome." [GOC:mah]
synonym: "regulation of sister chromatid cohesion at centromere" EXACT [GOC:mah]
is_a: GO:0007063 ! regulation of sister chromatid cohesion
relationship: regulates GO:0070601 ! centromeric sister chromatid cohesion

[Term]
id: GO:0070603
name: SWI/SNF-type complex
namespace: cellular_component
def: "A chromatin remodeling complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the core components." [GOC:mah, PMID:16155938]
synonym: "SWI-SNF global transcription activator complex " RELATED [CORUM:224]
synonym: "SWI-SNF-type complex" EXACT [GOC:mah]
is_a: GO:0016585 ! chromatin remodeling complex

[Term]
id: GO:0070604
name: PBAF complex
namespace: cellular_component
def: "A SWI/SNF-type complex that contains the ATPase product of the mammalian BAF180 gene." [GOC:mah, PMID:16155938, PMID:8895581]
synonym: "Polybromo- and BAF containing complex" EXACT [CORUM:565]
synonym: "SWI/SNF complex B" EXACT [CORUM:565]
is_a: GO:0070603 ! SWI/SNF-type complex

[Term]
id: GO:0070605
name: regulation of 1,3-alpha-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-1,3 glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds." [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0032948 ! regulation of alpha-glucan metabolic process
relationship: regulates GO:0070595 ! 1,3-alpha-glucan metabolic process

[Term]
id: GO:0070606
name: regulation of 1,3-alpha-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of alpha-1,3 glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds." [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "regulation of 1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan biosynthetic process" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan formation" EXACT [GOC:mah]
synonym: "regulation of alpha-1,3 glucan synthesis" EXACT [GOC:mah]
is_a: GO:0032949 ! regulation of alpha-glucan biosynthetic process
is_a: GO:0070605 ! regulation of 1,3-alpha-glucan metabolic process
relationship: regulates GO:0070596 ! 1,3-alpha-glucan biosynthetic process

[Term]
id: GO:0070607
name: regulation of cell wall 1,3-alpha-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-1,3 glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0070605 ! regulation of 1,3-alpha-glucan metabolic process
relationship: regulates GO:0070597 ! cell wall 1,3-alpha-glucan metabolic process

[Term]
id: GO:0070608
name: regulation of cell wall 1,3-alpha-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of 1,3-alpha-glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "regulation of cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3-glucan formation" EXACT [GOC:mah]
synonym: "regulation of cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0070606 ! regulation of 1,3-alpha-glucan biosynthetic process
is_a: GO:0070607 ! regulation of cell wall 1,3-alpha-glucan metabolic process
relationship: regulates GO:0070598 ! cell wall 1,3-alpha-glucan biosynthetic process

[Term]
id: GO:0070609
name: regulation of fungal-type cell wall 1,3-alpha-glucan metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-1,3 glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "regulation of ascospore wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "regulation of ascospore wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah]
synonym: "regulation of ascospore wall alpha-1,3 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0070607 ! regulation of cell wall 1,3-alpha-glucan metabolic process
relationship: regulates GO:0070599 ! fungal-type cell wall 1,3-alpha-glucan metabolic process

[Term]
id: GO:0070610
name: regulation of fungal-type cell wall 1,3-alpha-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of 1,3-alpha-glucans, compounds composed of glucose residues linked by 1,3-alpha-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah]
synonym: "regulation of fungal type cell wall 1,3-alpha-glucan biosynthetic process" RELATED [GOC:dph, GOC:tb]
synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall alpha-1,3-glucan formation" EXACT [GOC:mah]
synonym: "regulation of fungal-type cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0070608 ! regulation of cell wall 1,3-alpha-glucan biosynthetic process
is_a: GO:0070609 ! regulation of fungal-type cell wall 1,3-alpha-glucan metabolic process
relationship: regulates GO:0070600 ! fungal-type cell wall 1,3-alpha-glucan biosynthetic process

[Term]
id: GO:0070611
name: histone methyltransferase activity (H3-R2 specific)
namespace: molecular_function
def: "Catalysis of the addition of a methyl group to arginine at position 2 of the histone H3." [GOC:mah, PMID:17898714]
synonym: "histone methylase activity (H3-R2 specific)" EXACT [GOC:mah]
synonym: "histone-arginine N-methyltransferase activity (H3-R2 specific)" EXACT [GOC:mah]
is_a: GO:0008469 ! histone-arginine N-methyltransferase activity

[Term]
id: GO:0070612
name: histone methyltransferase activity (H2A-R3 specific)
namespace: molecular_function
def: "Catalysis of the addition of a methyl group to arginine at position 3 of the histone H2A." [GOC:mah, PMID:17898714]
synonym: "histone methylase activity (H2A-R3 specific)" EXACT [GOC:mah]
synonym: "histone-arginine N-methyltransferase activity (H2A-R3 specific)" EXACT [GOC:mah]
is_a: GO:0008469 ! histone-arginine N-methyltransferase activity

[Term]
id: GO:0070613
name: regulation of protein processing
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein processing, the posttranslational modification of a protein leading to the attainment of the full functional capacity of the protein." [GOC:mah]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0051246 ! regulation of protein metabolic process
relationship: regulates GO:0016485 ! protein processing

[Term]
id: GO:0070614
name: tungstate ion transport
namespace: biological_process
def: "The directed movement of tungstate (WO4 2-) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. Tungstate is a bivalent oxoanion of tungsten." [GOC:dh]
subset: gosubset_prok
is_a: GO:0015698 ! inorganic anion transport

[Term]
id: GO:0070615
name: nucleosome-dependent ATPase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, requiring the presence of one or more nucleosomes." [GOC:mah, PMID:19165147]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
synonym: "nucleosome-activated ATPase activity" EXACT [GOC:mah]
is_a: GO:0042623 ! ATPase activity, coupled

[Term]
id: GO:0070616
name: regulation of thiamin diphosphate biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamin diphosphate." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of thiamin diphosphate anabolism" EXACT [GOC:mah]
synonym: "regulation of thiamin diphosphate biosynthesis" EXACT [GOC:mah]
synonym: "regulation of thiamin diphosphate formation" EXACT [GOC:mah]
synonym: "regulation of thiamin diphosphate synthesis" EXACT [GOC:mah]
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
relationship: regulates GO:0009229 ! thiamin diphosphate biosynthetic process

[Term]
id: GO:0070617
name: negative regulation of thiamin diphosphate biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamin diphosphate." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of thiamin diphosphate biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of thiamin diphosphate biosynthetic process" EXACT [GOC:mah]
synonym: "downregulation of thiamin diphosphate biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of thiamin diphosphate biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of thiamin diphosphate anabolism" EXACT [GOC:mah]
synonym: "negative regulation of thiamin diphosphate biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of thiamin diphosphate formation" EXACT [GOC:mah]
synonym: "negative regulation of thiamin diphosphate synthesis" EXACT [GOC:mah]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0051198 ! negative regulation of coenzyme metabolic process
is_a: GO:0070616 ! regulation of thiamin diphosphate biosynthetic process
relationship: negatively_regulates GO:0009229 ! thiamin diphosphate biosynthetic process

[Term]
id: GO:0070618
name: Grb2-Sos complex
namespace: cellular_component
def: "A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013]
synonym: "Grb2-mSos1 complex" NARROW [CORUM:2545]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070619
name: Shc-Grb2-Sos complex
namespace: cellular_component
def: "A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7970708, PMID:8940013]
synonym: "Shc-Grb2-mSos1 complex, EGF stimulated" NARROW [CORUM:2553]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070620
name: EGFR-Grb2-Sos complex
namespace: cellular_component
def: "A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013]
synonym: "Egfr-Grb2-mSos1 complex, EGF stimulated" NARROW [CORUM:2548]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070621
name: EGFR-Shc-Grb2-Sos complex
namespace: cellular_component
def: "A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2, the adaptor protein SHC and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070622
name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex
namespace: cellular_component
def: "A protein complex that possesses UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; the bovine complex contains disulfide-linked homodimers of 166- and 51-kDa subunits and two identical, noncovalently associated 56-kDa subunits." [GOC:mah, PMID:8940155]
synonym: "N-acetylglucosamine-1-phosphotransferase complex" RELATED [CORUM:406]
synonym: "UDP-N-acetylglucosamine:lysosomal-enzyme N-acetylglucosamine-1-phosphotransferase complex" EXACT [PMID:8940155]
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0005764 ! lysosome

[Term]
id: GO:0070623
name: regulation of thiamin biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamin." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of thiamin anabolism" EXACT [GOC:mah]
synonym: "regulation of thiamin biosynthesis" EXACT [GOC:mah]
synonym: "regulation of thiamin formation" EXACT [GOC:mah]
synonym: "regulation of thiamin synthesis" EXACT [GOC:mah]
is_a: GO:0030656 ! regulation of vitamin metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0042762 ! regulation of sulfur metabolic process
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
relationship: regulates GO:0009228 ! thiamin biosynthetic process

[Term]
id: GO:0070624
name: negative regulation of thiamin biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamin." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of thiamin biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of thiamin biosynthetic process" EXACT [GOC:mah]
synonym: "downregulation of thiamin biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of thiamin biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of thiamin anabolism" EXACT [GOC:mah]
synonym: "negative regulation of thiamin biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of thiamin formation" EXACT [GOC:mah]
synonym: "negative regulation of thiamin synthesis" EXACT [GOC:mah]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0046137 ! negative regulation of vitamin metabolic process
is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process
is_a: GO:0051175 ! negative regulation of sulfur metabolic process
is_a: GO:0070623 ! regulation of thiamin biosynthetic process
relationship: negatively_regulates GO:0009228 ! thiamin biosynthetic process

[Term]
id: GO:0070625
name: zymogen granule exocytosis
namespace: biological_process
def: "The release of intracellular molecules contained within the zymogen granule by fusion of the granule with the plasma membrane of the oocyte, requiring calcium ions." [GOC:BHF, GOC:vk, PMID:17442889]
is_a: GO:0017156 ! calcium ion-dependent exocytosis

[Term]
id: GO:0070626
name: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "adenylosuccinase activity" BROAD [EC:4.3.2.2, GOC:mah]
synonym: "adenylosuccinate lyase activity" BROAD [GOC:mah]
synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah]
xref: EC:4.3.2.2
xref: KEGG:R04559
xref: MetaCyc:AICARSYN-RXN
is_a: GO:0016842 ! amidine-lyase activity

[Term]
id: GO:0070627
name: ferrous iron import
namespace: biological_process
def: "The directed movement of ferrous iron (Fe(II) or Fe2+) ions across a membrane into a cell or organelle." [GOC:mah]
synonym: "ferrous ion import" EXACT []
synonym: "ferrous iron uptake" EXACT []
is_a: GO:0015684 ! ferrous iron transport
is_a: GO:0034755 ! iron ion transmembrane transport

[Term]
id: GO:0070628
name: proteasome binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0070629
name: 1,4-alpha-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving alpha-1,4 glucans, compounds composed of glucose residues linked by 1,4-alpha-D-glucosidic bonds." [GOC:mah]
subset: gosubset_prok
synonym: "1,4-alpha-glucan metabolism" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan metabolic process" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan metabolism" EXACT [GOC:mah]
is_a: GO:0030978 ! alpha-glucan metabolic process

[Term]
id: GO:0070630
name: 1,4-alpha-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of alpha-1,4 glucans, compounds composed of glucose residues linked by 1,4-alpha-D-glucosidic bonds." [GOC:mah]
synonym: "1,4-alpha-glucan anabolism" EXACT [GOC:mah]
synonym: "1,4-alpha-glucan biosynthesis" EXACT [GOC:mah]
synonym: "1,4-alpha-glucan formation" EXACT [GOC:mah]
synonym: "1,4-alpha-glucan synthesis" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan anabolism" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan biosynthesis" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan biosynthetic process" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan formation" EXACT [GOC:mah]
synonym: "alpha-1,4 glucan synthesis" EXACT [GOC:mah]
is_a: GO:0030979 ! alpha-glucan biosynthetic process
is_a: GO:0070629 ! 1,4-alpha-glucan metabolic process

[Term]
id: GO:0070631
name: spindle pole body localization
namespace: biological_process
def: "Any process by which a spindle pole body is transported to, or maintained in, a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah]
synonym: "establishment and maintenance of spindle pole body localization" EXACT [GOC:mah]
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0070632
name: establishment of spindle pole body localization
namespace: biological_process
def: "Any process by which a spindle pole body is transported to a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah]
synonym: "spindle pole body positioning" EXACT [GOC:vw]
is_a: GO:0051649 ! establishment of localization in cell
is_a: GO:0070631 ! spindle pole body localization

[Term]
id: GO:0070633
name: transepithelial transport
namespace: biological_process
def: "The directed movement of a substance from one side of an epithelium to the other." [GOC:mah, ISBN:0716731363]
is_a: GO:0006810 ! transport

[Term]
id: GO:0070634
name: transepithelial ammonium transport
namespace: biological_process
def: "The directed movement of ammonium ions from one side of an epithelium to the other." [GOC:mah, GOC:yaf]
is_a: GO:0015696 ! ammonium transport
is_a: GO:0070633 ! transepithelial transport

[Term]
id: GO:0070635
name: nicotinamide riboside hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose." [MetaCyc:RXN-8441, PMID:19001417]
synonym: "N-ribosylnicotinamide hydrolase activity" EXACT [ChEBI:15927]
synonym: "nicotinamide ribonucleoside hydrolase activity" EXACT [ChEBI:15927]
xref: EC:3.2.2.-
xref: MetaCyc:RXN-8441
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0070636
name: nicotinic acid riboside hydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: nicotinic acid riboside + H2O = nicotinic acid + D-ribose." [GOC:mah, PMID:19001417]
synonym: "D-ribosylnicotinate hydrolase activity" EXACT [GOC:mah]
synonym: "D-ribosylnicotinic acid hydrolase activity" EXACT [ChEBI:27748]
synonym: "nicotinate ribonucleoside hydrolase activity" EXACT [GOC:mah]
synonym: "nicotinate riboside hydrolase activity" EXACT [GOC:mah]
synonym: "nicotinic acid ribonucleoside hydrolase activity" EXACT [GOC:mah]
xref: EC:3.2.2.-
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0070637
name: pyridine nucleoside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose." [ChEBI:47896, GOC:mah]
subset: gosubset_prok
synonym: "pyridine nucleoside metabolism" EXACT [GOC:mah]
is_a: GO:0009116 ! nucleoside metabolic process

[Term]
id: GO:0070638
name: pyridine nucleoside catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose." [ChEBI:47896, GOC:mah]
subset: gosubset_prok
synonym: "pyridine nucleoside breakdown" EXACT [GOC:mah]
synonym: "pyridine nucleoside catabolism" EXACT [GOC:mah]
synonym: "pyridine nucleoside degradation" EXACT [GOC:mah]
is_a: GO:0070637 ! pyridine nucleoside metabolic process

[Term]
id: GO:0070639
name: vitamin D2 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin D2, (3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol." [ChEBI:28934, GOC:BHF, GOC:mah]
synonym: "calciferol metabolic process" EXACT [ChEBI:28934]
synonym: "ergocalciferol metabolic process" EXACT [ChEBI:28934]
synonym: "vitamin D2 metabolism" EXACT [GOC:mah]
is_a: GO:0042359 ! vitamin D metabolic process

[Term]
id: GO:0070640
name: vitamin D3 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol." [ChEBI:28940, GOC:BHF, GOC:mah]
synonym: "calciol metabolic process" EXACT [ChEBI:28940]
synonym: "cholecalciferol metabolic process" EXACT [ChEBI:28940]
synonym: "vitamin D3 metabolism" EXACT [GOC:mah]
is_a: GO:0042359 ! vitamin D metabolic process

[Term]
id: GO:0070641
name: vitamin D4 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin D4, (3S,5Z,7E)-9,10-secoergosta-5,7,10(19)-trien-3-ol." [ChEBI:33237, GOC:BHF, GOC:mah]
synonym: "vitamin D4 metabolism" EXACT [GOC:mah]
is_a: GO:0042359 ! vitamin D metabolic process

[Term]
id: GO:0070642
name: vitamin D5 metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving vitamin D5, (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,4S)-4-ethyl-1,5-dimethylhexyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-1-cyclohexanol." [GOC:BHF, GOC:mah, PubChem_Compound:9547700]
synonym: "vitamin D5 metabolism" EXACT [GOC:mah]
is_a: GO:0042359 ! vitamin D metabolic process

[Term]
id: GO:0070643
name: vitamin D 25-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the hydroxylation of C-25 of any form of vitamin D." [GOC:BHF, GOC:mah]
synonym: "calciferol 25-hydroxylase activity" NARROW [GOC:mah]
synonym: "cholecalciferol 25-hydroxylase activity" NARROW [GOC:mah]
synonym: "ergocalciferol 25-hydroxylase activity" NARROW [GOC:mah]
synonym: "vitamin D2 25-hydroxylase activity" NARROW [GOC:mah]
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0070644
name: vitamin D response element binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:vk, PMID:17426122]
synonym: "VDRE binding" EXACT [GOC:vk, PMID:17426122]
is_a: GO:0010843 ! promoter binding

[Term]
id: GO:0070645
name: Ubisch body
namespace: cellular_component
def: "A small, granular structure that is found in the extracellular matrix of cell of the secretory tapetal layer that surrounds developing pollen grains. Ubisch bodies have a sporopollenin coat, are attached to the peritapetal wall, and may play a role in pollen development." [GOC:ecd, GOC:mah, PMID:14612572, PMID:16524248]
synonym: "orbicule" EXACT [PMID:14612572]
is_a: GO:0044420 ! extracellular matrix part

[Term]
id: GO:0070646
name: protein modification by small protein removal
namespace: biological_process
def: "A protein modification process by which one or more covalently attached moieties of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein." [GOC:mah]
is_a: GO:0070647 ! protein modification by small protein conjugation or removal

[Term]
id: GO:0070647
name: protein modification by small protein conjugation or removal
namespace: biological_process
def: "A protein modification process by which one or more moieties of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah]
subset: goslim_pombe
is_a: GO:0006464 ! protein modification process

[Term]
id: GO:0070648
name: formin-nucleated actin cable
namespace: cellular_component
def: "An actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. In fungal cells, myosin motors transport cargo along actin cables toward sites of polarized cell growth; actin cables may play a similar role in pollen tube growth." [PMID:14671023, PMID:16959963]
is_a: GO:0032432 ! actin filament bundle

[Term]
id: GO:0070649
name: formin-nucleated actin cable assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:mah, PMID:14671023, PMID:16959963]
synonym: "formin-nucleated actin cable formation" EXACT [GOC:mah]
is_a: GO:0051017 ! actin filament bundle assembly

[Term]
id: GO:0070650
name: actin filament bundle distribution
namespace: biological_process
def: "Any cellular process that establishes the spatial arrangement of actin filament bundles within the cell." [GOC:mah]
is_a: GO:0030036 ! actin cytoskeleton organization

[Term]
id: GO:0070651
name: nonfunctional rRNA decay
namespace: biological_process
def: "An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system." [GOC:mah, GOC:rn, PMID:17188037, PMID:19390089]
synonym: "NRD" RELATED [GOC:rn]
is_a: GO:0016075 ! rRNA catabolic process

[Term]
id: GO:0070652
name: HAUS complex
namespace: cellular_component
def: "A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217]
synonym: "HAUS augmin complex" EXACT [GOC:mm2]
is_a: GO:0005875 ! microtubule associated complex

[Term]
id: GO:0070653
name: high-density lipoprotein receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a high-density lipoprotein receptor." [GOC:BHF, GOC:mah]
synonym: "HDL receptor binding" EXACT [GOC:mah]
is_a: GO:0070325 ! lipoprotein receptor binding

[Term]
id: GO:0070654
name: sensory epithelium regeneration
namespace: biological_process
def: "The regrowth of a sensory epithelium following its loss or destruction." [GOC:dsf, PMID:19381250]
is_a: GO:0042246 ! tissue regeneration

[Term]
id: GO:0070655
name: mechanosensory epithelium regeneration
namespace: biological_process
def: "The regrowth of lost or destroyed mechanosensory epithelia." [GOC:dsf, PMID:19381250]
is_a: GO:0070654 ! sensory epithelium regeneration

[Term]
id: GO:0070656
name: mechanoreceptor differentiation involved in mechanosensory epithelium regeneration
namespace: biological_process
def: "Differentiation of new mechanoreceptors to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250]
is_a: GO:0042490 ! mechanoreceptor differentiation
relationship: part_of GO:0070655 ! mechanosensory epithelium regeneration

[Term]
id: GO:0070657
name: neuromast regeneration
namespace: biological_process
def: "The regrowth of a neuromast following its loss or destruction." [GOC:dsf, PMID:19381250]
is_a: GO:0070655 ! mechanosensory epithelium regeneration

[Term]
id: GO:0070658
name: neuromast hair cell differentiation involved in neuromast regeneration
namespace: biological_process
def: "Differentiation of new neuromast sensory hair cells to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250]
is_a: GO:0048886 ! neuromast hair cell differentiation
is_a: GO:0070656 ! mechanoreceptor differentiation involved in mechanosensory epithelium regeneration
relationship: part_of GO:0070657 ! neuromast regeneration

[Term]
id: GO:0070659
name: inner ear sensory epithelium regeneration
namespace: biological_process
def: "The regrowth of lost or destroyed inner ear sensory epithelia." [GOC:dsf, PMID:19381250]
is_a: GO:0070655 ! mechanosensory epithelium regeneration

[Term]
id: GO:0070660
name: inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration
namespace: biological_process
def: "Differentiation of new inner ear sensory hair cells to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250]
is_a: GO:0060113 ! inner ear receptor cell differentiation
is_a: GO:0070656 ! mechanoreceptor differentiation involved in mechanosensory epithelium regeneration
relationship: part_of GO:0070659 ! inner ear sensory epithelium regeneration

[Term]
id: GO:0070661
name: leukocyte proliferation
namespace: biological_process
def: "The expansion of a leukocyte population by cell division." [GOC:add]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0070662
name: mast cell proliferation
namespace: biological_process
def: "The expansion of a mast cell population by cell division." [GOC:add]
is_a: GO:0070661 ! leukocyte proliferation

[Term]
id: GO:0070663
name: regulation of leukocyte proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah]
is_a: GO:0042127 ! regulation of cell proliferation
relationship: regulates GO:0070661 ! leukocyte proliferation

[Term]
id: GO:0070664
name: negative regulation of leukocyte proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah]
synonym: "down regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "down-regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "downregulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "inhibition of leukocyte proliferation" NARROW [GOC:mah]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0070663 ! regulation of leukocyte proliferation
relationship: negatively_regulates GO:0070661 ! leukocyte proliferation

[Term]
id: GO:0070665
name: positive regulation of leukocyte proliferation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah]
synonym: "activation of leukocyte proliferation" NARROW [GOC:mah]
synonym: "stimulation of leukocyte proliferation" NARROW [GOC:mah]
synonym: "up regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "up-regulation of leukocyte proliferation" EXACT [GOC:mah]
synonym: "upregulation of leukocyte proliferation" EXACT [GOC:mah]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0070663 ! regulation of leukocyte proliferation
relationship: positively_regulates GO:0070661 ! leukocyte proliferation

[Term]
id: GO:0070666
name: regulation of mast cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mast cell proliferation." [GOC:add, GOC:mah]
is_a: GO:0070663 ! regulation of leukocyte proliferation
relationship: regulates GO:0070662 ! mast cell proliferation

[Term]
id: GO:0070667
name: negative regulation of mast cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of mast cell proliferation." [GOC:add, GOC:mah]
synonym: "down regulation of mast cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of mast cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of mast cell proliferation" EXACT [GOC:mah]
synonym: "inhibition of mast cell proliferation" NARROW [GOC:mah]
is_a: GO:0070664 ! negative regulation of leukocyte proliferation
is_a: GO:0070666 ! regulation of mast cell proliferation
relationship: negatively_regulates GO:0070662 ! mast cell proliferation

[Term]
id: GO:0070668
name: positive regulation of mast cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of mast cell proliferation." [GOC:add, GOC:mah]
synonym: "activation of mast cell proliferation" NARROW [GOC:mah]
synonym: "stimulation of mast cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of mast cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of mast cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of mast cell proliferation" EXACT [GOC:mah]
is_a: GO:0070665 ! positive regulation of leukocyte proliferation
is_a: GO:0070666 ! regulation of mast cell proliferation
relationship: positively_regulates GO:0070662 ! mast cell proliferation

[Term]
id: GO:0070669
name: response to interleukin-2
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus." [GOC:mah]
synonym: "response to IL-2" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine stimulus

[Term]
id: GO:0070670
name: response to interleukin-4
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus." [GOC:mah]
synonym: "response to IL-4" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine stimulus

[Term]
id: GO:0070671
name: response to interleukin-12
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus." [GOC:mah]
synonym: "response to IL-12" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine stimulus

[Term]
id: GO:0070672
name: response to interleukin-15
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus." [GOC:mah]
synonym: "response to IL-15" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine stimulus

[Term]
id: GO:0070673
name: response to interleukin-18
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus." [GOC:mah]
synonym: "response to IL-18" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine stimulus

[Term]
id: GO:0070674
name: hypoxanthine dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "hypoxanthine oxidoreductase activity" BROAD [EC:1.17.1.4]
synonym: "hypoxanthine-NAD oxidoreductase activity" EXACT [EC:1.17.1.4]
synonym: "hypoxanthine/NAD(+) oxidoreductase activity" EXACT [EC:1.17.1.4]
synonym: "hypoxanthine/NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4]
synonym: "hypoxanthine:NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4]
synonym: "NAD-hypoxanthine dehydrogenase activity" EXACT [EC:1.17.1.4]
is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor

[Term]
id: GO:0070675
name: hypoxanthine oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2." [GOC:mah, GOC:pde]
subset: gosubset_prok
synonym: "hypoxanthine-xanthine oxidase activity" BROAD [EC:1.17.3.2]
synonym: "hypoxanthine:O(2) oxidoreductase activity" EXACT [EC:1.17.3.2]
synonym: "hypoxanthine:O2 oxidoreductase activity" EXACT [EC:1.17.3.2]
synonym: "hypoxanthine:oxygen oxidoreductase activity" EXACT [EC:1.17.3.2]
synonym: "schardinger enzyme" RELATED [EC:1.17.3.2]
synonym: "Schardinger enzyme activity" RELATED [EC:1.17.3.2]
synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.3.2]
is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor

[Term]
id: GO:0070676
name: intralumenal vesicle formation
namespace: biological_process
def: "The evagination of the endosome membrane, resulting in the formation of a vesicle." [GOC:jp, PMID:19234443]
synonym: "endosome membrane budding" EXACT [GOC:jp, GOC:mah]
is_a: GO:0006900 ! membrane budding

[Term]
id: GO:0070677
name: rRNA (cytosine-2'-O-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine." [GOC:mah, PMID:19400805]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008171 ! O-methyltransferase activity
is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity

[Term]
id: GO:0070678
name: preprotein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing." [GOC:imk, GOC:mah, PMID:12914940]
synonym: "unprocessed protein binding" EXACT [GOC:imk]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0070679
name: inositol 1,4,5 trisphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah]
subset: gosubset_prok
synonym: "InsP3 binding" EXACT [GOC:mah]
synonym: "IP3 binding" EXACT [GOC:mah]
is_a: GO:0043178 ! alcohol binding

[Term]
id: GO:0070680
name: asparaginyl-tRNAAsn biosynthesis via transamidation
namespace: biological_process
def: "A tRNA aminoacylation process in which asparaginyl-tRNAAsn is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating aspartyl-tRNA synthetase generates the misacylated L-aspartyl-tRNAAsn species, and in the second step it is amidated to the correctly charged L-asparaginyl-tRNAAsn by the heterotrimeric aspartyl-tRNAAsn amidotransferase." [GOC:mah, MetaCyc:PWY490-4]
xref: MetaCyc:PWY490-4
is_a: GO:0043039 ! tRNA aminoacylation

[Term]
id: GO:0070681
name: glutaminyl-tRNAGln biosynthesis via transamidation
namespace: biological_process
def: "A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase." [GOC:mah, MetaCyc:PWY-5921]
xref: MetaCyc:PWY-5921
is_a: GO:0043039 ! tRNA aminoacylation

[Term]
id: GO:0070682
name: proteasome regulatory particle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex." [GOC:mah, GOC:rb, PMID:19412159]
synonym: "proteasome regulatory complex assembly" EXACT [GOC:mah]
is_a: GO:0043248 ! proteasome assembly

[Term]
id: GO:0070683
name: decatenation checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that blocks cell cycle progression from G2 to M phase until sister chromatids are sufficiently separated." [GOC:jp]
synonym: "topo II checkpoint" EXACT [GOC:jp]
synonym: "topoisomerase II checkpoint" EXACT [GOC:jp]
is_a: GO:0031576 ! G2/M transition checkpoint

[Term]
id: GO:0070684
name: seminal clot liquefaction
namespace: biological_process
def: "The reproductive process by which coagulated semen becomes liquid following ejaculation, allowing the progressive release of motile spermatozoa." [GOC:mah, PMID:18482984]
synonym: "semen liquefaction" EXACT [PMID:18482984]
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0007320 ! insemination

[Term]
id: GO:0070685
name: macropinocytic cup
namespace: cellular_component
def: "A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin." [PMID:12538772, PMID:16968738, PMID:9044041]
synonym: "crown" EXACT [GOC:pf, PMID:9044041]
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0070686
name: macropinocytic cup membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a macropinocytic cup." [GOC:mah]
synonym: "crown membrane" EXACT [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0070685 ! macropinocytic cup

[Term]
id: GO:0070687
name: macropinocytic cup cytoskeleton
namespace: cellular_component
def: "The part of the cortical actin cytoskeleton that forms part of a macropinocytic cup." [GOC:mah]
synonym: "crown cytoskeleton" EXACT [GOC:mah]
is_a: GO:0044463 ! cell projection part
relationship: part_of GO:0030864 ! cortical actin cytoskeleton
relationship: part_of GO:0070685 ! macropinocytic cup

[Term]
id: GO:0070688
name: MLL5-L complex
namespace: cellular_component
def: "A protein complex that can methylate lysine-4 of histone H3 and plays an essential role in retinoic-acid-induced granulopoiesis. MLL5 is the catalytic methyltransferase subunit, and the complex also contains serine/threonine kinase 38 (STK38), protein phosphatase 1 catalytic subunits, the host cell factor-1 N-terminal subunit, beta-actin, and O-GlcNAc transferase; the human genes encoding the subunits are MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT, respectively." [GOC:mah, PMID:19377461]
is_a: GO:0035097 ! histone methyltransferase complex

[Term]
id: GO:0070689
name: threonine catabolic process to propionate
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid) to form the compound propionate." [GOC:mah, MetaCyc:PWY-5437]
subset: gosubset_prok
synonym: "threonine breakdown to propionate" EXACT [GOC:mah]
synonym: "threonine catabolism to propionate" EXACT [GOC:mah]
synonym: "threonine degradation to propionate" EXACT [GOC:mah]
xref: MetaCyc:PWY-5437
is_a: GO:0006567 ! threonine catabolic process

[Term]
id: GO:0070690
name: threonine catabolic process to acetyl-CoA
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid) to form the compound acetyl-Coenzyme A." [GOC:mah, MetaCyc:PWY-5436]
subset: gosubset_prok
synonym: "threonine breakdown to acetyl-CoA" EXACT [GOC:mah]
synonym: "threonine catabolism to acetyl-CoA" EXACT [GOC:mah]
synonym: "threonine degradation to acetyl-CoA" EXACT [GOC:mah]
xref: MetaCyc:PWY-5436
is_a: GO:0006567 ! threonine catabolic process

[Term]
id: GO:0070691
name: dimeric positive transcription elongation factor complex b
namespace: cellular_component
def: "A positive transcription elongation factor complex b that comprises two subunits; an example is the budding yeast complex containing Svg1p (also called Bur1p) and Bur2p." [GOC:mah, PMID:16721054, PMID:19328067]
synonym: "Bur1/Bur2 complex" NARROW [PMID:16721054, PMID:19328067]
synonym: "Sgv1/Bur2 complex" NARROW [GOC:mah]
is_a: GO:0008024 ! positive transcription elongation factor complex b

[Term]
id: GO:0070692
name: trimeric positive transcription elongation factor complex b
namespace: cellular_component
def: "A positive transcription elongation factor complex b that comprises three subunits; an example is the budding yeast Ctk complex, which consists of Ctk1p, Ctk2p and Ctk3p." [GOC:mah, PMID:16721054, PMID:19328067]
synonym: "CTDK-I complex" NARROW [PMID:16721054, PMID:19328067]
synonym: "Ctk complex" NARROW [PMID:16721054]
is_a: GO:0008024 ! positive transcription elongation factor complex b

[Term]
id: GO:0070693
name: P-TEFb-cap methyltransferase complex
namespace: cellular_component
def: "A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping methyltransferase." [PMID:17332744, PMID:19328067]
synonym: "Cdk9-Pcm1 complex" NARROW [GOC:vw]
synonym: "P-TEFb-Pcm1 complex" NARROW [GOC:vw]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070694
name: deoxyribonucleoside 5'-monophosphate N-glycosidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H20 = deoxyribose 5-monophosphate + a purine or pyrimidine base." [GOC:ab, PMID:17234634]
subset: gosubset_prok
synonym: "deoxynucleoside 5'-monophosphate N-glycosidase activity" EXACT []
xref: EC:3.2.2.-
xref: IMG:03312
is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds

[Term]
id: GO:0070695
name: FHF complex
namespace: cellular_component
def: "A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex)." [GOC:ab, GOC:mah, PMID:18799622]
comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0070696
name: transmembrane receptor protein serine/threonine kinase binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity." [GOC:BHF, GOC:mah]
is_a: GO:0033612 ! receptor serine/threonine kinase binding

[Term]
id: GO:0070697
name: activin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an activin receptor." [GOC:BHF, GOC:vk]
is_a: GO:0070696 ! transmembrane receptor protein serine/threonine kinase binding

[Term]
id: GO:0070698
name: type I activin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type I activin receptor." [GOC:BHF, GOC:vk]
is_a: GO:0070697 ! activin receptor binding

[Term]
id: GO:0070699
name: type II activin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type II activin receptor." [GOC:BHF, GOC:vk]
is_a: GO:0070697 ! activin receptor binding

[Term]
id: GO:0070700
name: BMP receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a BMP receptor." [GOC:BHF, GOC:vk]
synonym: "bone morphogenetic protein receptor binding" EXACT [GOC:mah]
is_a: GO:0070696 ! transmembrane receptor protein serine/threonine kinase binding

[Term]
id: GO:0070701
name: mucus layer
namespace: cellular_component
def: "An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes." [GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394]
is_a: GO:0044421 ! extracellular region part

[Term]
id: GO:0070702
name: inner mucus layer
namespace: cellular_component
def: "The inner of two mucus layers secreted by epithelial cells in the colon; the inner mucus layer is firmly attached to the epithelium, is densely packed with a compact stratified appearance and is devoid of bacteria." [GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394]
is_a: GO:0070701 ! mucus layer

[Term]
id: GO:0070703
name: outer mucus layer
namespace: cellular_component
def: "The outer of two mucus layers secreted by epithelial cells in the colon; the outer mucus layer is loosely packed and can be colonized by bacteria." [GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394]
is_a: GO:0070701 ! mucus layer

[Term]
id: GO:0070704
name: sterol desaturase activity
namespace: molecular_function
def: "Catalysis of the introduction of a double bond into a sterol molecule." [GOC:mah, GOC:vw]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0070705
name: RNA nucleotide insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of one or more nucleotides." [GOC:cb, GOC:mah]
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0070706
name: RNA nucleotide deletion
namespace: biological_process
def: "The modification of an RNA molecule by removal of a single nucleotide." [GOC:cb, GOC:mah]
synonym: "RNA nucleotide excision" EXACT [GOC:cb, GOC:mah]
is_a: GO:0009451 ! RNA modification

[Term]
id: GO:0070707
name: RNA dinucleotide insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of a dinucleotide." [GOC:cb, GOC:mah]
is_a: GO:0070705 ! RNA nucleotide insertion

[Term]
id: GO:0070708
name: RNA cytidine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of a cytidine nucleotide." [GOC:cb, GOC:mah]
synonym: "RNA C insertion" EXACT [GOC:mah]
is_a: GO:0070705 ! RNA nucleotide insertion

[Term]
id: GO:0070709
name: RNA guanosine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of a guanosine nucleotide." [GOC:cb, GOC:mah]
synonym: "RNA G insertion" EXACT [GOC:mah]
is_a: GO:0070705 ! RNA nucleotide insertion

[Term]
id: GO:0070710
name: RNA uridine deletion
namespace: biological_process
def: "The modification of an RNA molecule by removal of a uridine nucleotide." [GOC:cb, GOC:mah]
synonym: "RNA U deletion" EXACT [GOC:mah]
synonym: "RNA uridine excision" EXACT [GOC:cb, GOC:mah]
is_a: GO:0070706 ! RNA nucleotide deletion

[Term]
id: GO:0070711
name: RNA adenosine-uridine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of an adenosine-uridine dinucleotide." [GOC:cb, GOC:mah]
synonym: "RNA AU insertion" EXACT [GOC:mah]
is_a: GO:0070707 ! RNA dinucleotide insertion

[Term]
id: GO:0070712
name: RNA cytidine-uridine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of an cytidine-uridine dinucleotide." [GOC:cb, GOC:mah]
synonym: "RNA CU insertion" EXACT [GOC:mah]
is_a: GO:0070707 ! RNA dinucleotide insertion

[Term]
id: GO:0070713
name: RNA guanosine-cytidine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of an guanosine-cytidine dinucleotide." [GOC:cb, GOC:mah]
synonym: "RNA GC insertion" EXACT [GOC:mah]
is_a: GO:0070707 ! RNA dinucleotide insertion

[Term]
id: GO:0070714
name: RNA guanosine-uridine insertion
namespace: biological_process
def: "The modification of an RNA molecule by insertion of an guanosine-uridine insertion dinucleotide." [GOC:cb, GOC:mah]
synonym: "RNA GU insertion" EXACT [GOC:mah]
is_a: GO:0070707 ! RNA dinucleotide insertion

[Term]
id: GO:0070715
name: sodium-dependent organic cation transport
namespace: biological_process
def: "The directed, sodium-dependent, movement of organic cations into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:BHF, GOC:mah]
is_a: GO:0015695 ! organic cation transport

[Term]
id: GO:0070716
name: mismatch repair involved in maintenance of fidelity during DNA-dependent DNA replication
namespace: biological_process
def: "A mismatch repair process that corrects errors introduced during DNA replication." [GOC:BHF, GOC:mah]
subset: gosubset_prok
is_a: GO:0006298 ! mismatch repair
is_a: GO:0045005 ! maintenance of fidelity during DNA-dependent DNA replication

[Term]
id: GO:0070717
name: poly-purine tract binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule." [GOC:mah]
is_a: GO:0003727 ! single-stranded RNA binding

[Term]
id: GO:0070718
name: alphaPDGFR-SHP-2 complex
namespace: cellular_component
def: "A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348]
synonym: "PDGFRA-SHP-2 complex, PDGF stimulated" NARROW [CORUM:3183]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070719
name: alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex
namespace: cellular_component
def: "A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348]
synonym: "PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated" NARROW [CORUM:2551]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070720
name: Grb2-SHP-2 complex
namespace: cellular_component
def: "A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348]
synonym: "GRB2-SHP-2 complex, PDGF stimulated" NARROW [CORUM:3186]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070721
name: ISGF3 complex
namespace: cellular_component
def: "A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein." [GOC:mah, PMID:8943351]
synonym: "interferon-stimulated gene factor 3 transcription complex" EXACT [CORUM:60]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0070722
name: Tle3-Aes complex
namespace: cellular_component
def: "A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product." [GOC:mah, PMID:8955148]
synonym: "Grg3b-Grg5 complex" EXACT [CORUM:3130, PMID:8955148]
is_a: GO:0017053 ! transcriptional repressor complex

[Term]
id: GO:0070723
name: response to cholesterol
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus." [GOC:BHF, GOC:vk]
is_a: GO:0033993 ! response to lipid

[Term]
id: GO:0070724
name: BMP receptor complex
namespace: cellular_component
def: "A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits." [GOC:mah, GOC:mh, PMID:19377468]
synonym: "bone morphogenetic protein receptor complex" EXACT [GOC:mah]
is_a: GO:0043235 ! receptor complex
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0005887 ! integral to plasma membrane

[Term]
id: GO:0070725
name: Yb body
namespace: cellular_component
def: "A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell." [GOC:sart, PMID:19433453]
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0070726
name: cell wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells." [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0042546 ! cell wall biogenesis

[Term]
id: GO:0070727
name: cellular macromolecule localization
namespace: biological_process
def: "Any process by which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah]
is_a: GO:0033036 ! macromolecule localization
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0070728
name: leucine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 2-amino-4-methylpentanoic acid." [ChEBI:25017, GOC:BHF, GOC:mah]
synonym: "Leu binding" EXACT [GOC:mah]
is_a: GO:0016597 ! amino acid binding

[Term]
id: GO:0070729
name: cyclic nucleotide transport
namespace: biological_process
def: "The directed movement of a cyclic nucleotide, any nucleotide in which phosphate group is in diester linkage to two positions on the sugar residue, into, out of or within a cell." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
is_a: GO:0006862 ! nucleotide transport

[Term]
id: GO:0070730
name: cAMP transport
namespace: biological_process
def: "The directed movement of cyclic AMP (cAMP), into, out of or within a cell." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "cyclic AMP transport" EXACT [GOC:mah]
is_a: GO:0070729 ! cyclic nucleotide transport

[Term]
id: GO:0070731
name: cGMP transport
namespace: biological_process
def: "The directed movement of cyclic GMP (cGMP), into, out of or within a cell." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"]
synonym: "cyclic GMP transport" EXACT [GOC:mah]
is_a: GO:0070729 ! cyclic nucleotide transport

[Term]
id: GO:0070732
name: spindle envelope
namespace: cellular_component
def: "An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase." [GOC:mah, GOC:sart, PMID:19417004, PMID:6428889]
subset: goslim_candida
subset: goslim_yeast
is_a: GO:0031967 ! organelle envelope

[Term]
id: GO:0070733
name: protein adenylyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to specific residues of target proteins." [GOC:mah, PMID:19039103, PMID:19362538]
subset: gosubset_prok
synonym: "adenosine monophosphate-protein transferase activity" EXACT [GOC:mah]
synonym: "AMPylator" RELATED [GOC:mah]
is_a: GO:0070566 ! adenylyltransferase activity

[Term]
id: GO:0070734
name: histone H3-K27 methylation
namespace: biological_process
def: "The modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:mah]
synonym: "histone H3 K27 methylation" EXACT [GOC:mah]
synonym: "histone H3K27me" EXACT [GOC:mah]
synonym: "histone lysine H3 K27 methylation" EXACT [GOC:mah]
is_a: GO:0034968 ! histone lysine methylation

[Term]
id: GO:0070735
name: protein-glycine ligase activity
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target protein." [GOC:mah, PMID:19524510]
synonym: "protein glycylase activity" EXACT [GOC:mah]
xref: EC:6.3.2.-
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0070736
name: protein-glycine ligase activity, initiating
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein." [GOC:mah, PMID:19524510]
synonym: "protein glycylase activity, initiating" EXACT [GOC:mah]
xref: EC:6.3.2.-
is_a: GO:0070735 ! protein-glycine ligase activity

[Term]
id: GO:0070737
name: protein-glycine ligase activity, elongating
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain." [GOC:mah, PMID:19524510]
synonym: "protein glycylase activity, elongating" EXACT [GOC:mah]
xref: EC:6.3.2.-
is_a: GO:0070735 ! protein-glycine ligase activity

[Term]
id: GO:0070738
name: tubulin-glycine ligase activity
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target tubulin molecule; acts on alpha or beta tubulin." [GOC:mah, PMID:19524510]
synonym: "tubulin glycylase activity" EXACT [GOC:mah]
xref: EC:6.3.2.-
is_a: GO:0070735 ! protein-glycine ligase activity

[Term]
id: GO:0070739
name: protein-glutamic acid ligase activity
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein." [GOC:mah, PMID:19524510]
synonym: "protein glutamylase activity" EXACT [GOC:mah]
synonym: "protein-glutamate ligase activity" EXACT [GOC:mah]
xref: EC:6.3.2.-
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0070740
name: tubulin-glutamic acid ligase activity
namespace: molecular_function
def: "Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510]
synonym: "tubulin glutamylase activity" EXACT [GOC:mah]
synonym: "tubulin-glutamate ligase activity" EXACT [GOC:mah]
xref: EC:6.3.2.-
is_a: GO:0070739 ! protein-glutamic acid ligase activity

[Term]
id: GO:0070741
name: response to interleukin-6
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah]
synonym: "response to IL-6" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine stimulus

[Term]
id: GO:0070742
name: C2H2 zinc finger domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion." [GOC:BHF, GOC:mah, Pfam:PF00096]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070743
name: interleukin-23 complex
namespace: cellular_component
def: "A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space." [GOC:add, PMID:11114383, PMID:15999093]
comment: Note that this heterodimeric cytokine utilizes the same beta subunit as IL-12.
synonym: "IL-23 complex" EXACT [GOC:add]
synonym: "IL12B" NARROW [GOC:add]
synonym: "IL23A" NARROW [GOC:add]
synonym: "p19" NARROW [GOC:add]
synonym: "p40" NARROW [GOC:add]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0070744
name: interleukin-27 complex
namespace: cellular_component
def: "A protein complex that is composed of an interleukin-27p28 subunit (product of the IL27 gene) and an EBI3 subunit and is secreted into the extracellular space." [GOC:add, PMID:15999093, PMID:19161428]
comment: Note that this heterodimeric cytokine utilizes the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-35 uses for its beta chain. Also note that the product of the IL27 gene is the alpha subunit of IL-27. The functional IL-27 protein complex requires both subunits.
synonym: "EBI3" NARROW [GOC:add]
synonym: "IL-27 complex" EXACT [GOC:add]
synonym: "IL27" NARROW [GOC:add]
synonym: "p28" NARROW [GOC:add]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0070745
name: interleukin-35 complex
namespace: cellular_component
def: "A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space." [GOC:add, PMID:19161428, PMID:19161429]
comment: Note that this heterodimeric cytokine utilizes the same IL-12p35 subunit as its alpha chain as IL-12 uses and the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-27 uses. IL-35 requires both subunits -- there is no separate IL35 gene.
synonym: "EBI3" NARROW [GOC:add]
synonym: "IL-35 complex" EXACT [GOC:add]
synonym: "IL12A" NARROW [GOC:add]
synonym: "p35" NARROW [GOC:add]
is_a: GO:0043234 ! protein complex
is_a: GO:0044421 ! extracellular region part
relationship: part_of GO:0005615 ! extracellular space

[Term]
id: GO:0070746
name: interleukin-35 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with interleukin-35." [GOC:add]
synonym: "IL-35 binding" EXACT [GOC:add]
is_a: GO:0019955 ! cytokine binding

[Term]
id: GO:0070747
name: interleukin-35 receptor activity
namespace: molecular_function
def: "Combining with interleukin-35 to initiate a change in cell activity." [GOC:add]
synonym: "IL-35 receptor activity" EXACT [GOC:add]
synonym: "IL-35R" EXACT [GOC:add]
is_a: GO:0004896 ! cytokine receptor activity
is_a: GO:0070746 ! interleukin-35 binding

[Term]
id: GO:0070748
name: interleukin-35 receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the interleukin-35 receptor." [GOC:add]
synonym: "IL-35" NARROW [GOC:add]
synonym: "interleukin-35 receptor ligand" NARROW [GOC:add]
is_a: GO:0005126 ! cytokine receptor binding

[Term]
id: GO:0070749
name: interleukin-35 biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add]
synonym: "IL-35 biosynthesis" EXACT [GOC:mah]
synonym: "IL-35 biosynthetic process" EXACT [GOC:add]
synonym: "interleukin-35 anabolism" EXACT [GOC:mah]
synonym: "interleukin-35 biosynthesis" EXACT [GOC:mah]
synonym: "interleukin-35 formation" EXACT [GOC:mah]
synonym: "interleukin-35 synthesis" EXACT [GOC:mah]
is_a: GO:0042089 ! cytokine biosynthetic process
relationship: part_of GO:0070753 ! interleukin-35 production

[Term]
id: GO:0070750
name: regulation of interleukin-35 biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add]
synonym: "regulation of IL-35 biosynthesis" EXACT [GOC:mah]
synonym: "regulation of IL-35 biosynthetic process" EXACT [GOC:add]
synonym: "regulation of interleukin-35 anabolism" EXACT [GOC:mah]
synonym: "regulation of interleukin-35 biosynthesis" EXACT [GOC:mah]
synonym: "regulation of interleukin-35 formation" EXACT [GOC:mah]
synonym: "regulation of interleukin-35 synthesis" EXACT [GOC:mah]
is_a: GO:0042035 ! regulation of cytokine biosynthetic process
is_a: GO:0070754 ! regulation of interleukin-35 production
relationship: regulates GO:0070749 ! interleukin-35 biosynthetic process

[Term]
id: GO:0070751
name: negative regulation of interleukin-35 biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add]
synonym: "down regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
synonym: "downregulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of interleukin-35 biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of IL-35 biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of IL-35 biosynthetic process" EXACT [GOC:add]
synonym: "negative regulation of interleukin-35 anabolism" EXACT [GOC:mah]
synonym: "negative regulation of interleukin-35 biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of interleukin-35 formation" EXACT [GOC:mah]
synonym: "negative regulation of interleukin-35 synthesis" EXACT [GOC:mah]
is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process
is_a: GO:0070750 ! regulation of interleukin-35 biosynthetic process
relationship: negatively_regulates GO:0070749 ! interleukin-35 biosynthetic process

[Term]
id: GO:0070752
name: positive regulation of interleukin-35 biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35." [GOC:add]
synonym: "activation of interleukin-35 biosynthetic process" NARROW [GOC:mah]
synonym: "positive regulation of IL-35 biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of IL-35 biosynthetic process" EXACT [GOC:add]
synonym: "positive regulation of interleukin-35 anabolism" EXACT [GOC:mah]
synonym: "positive regulation of interleukin-35 biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of interleukin-35 formation" EXACT [GOC:mah]
synonym: "positive regulation of interleukin-35 synthesis" EXACT [GOC:mah]
synonym: "stimulation of interleukin-35 biosynthetic process" NARROW [GOC:mah]
synonym: "up regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
synonym: "up-regulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
synonym: "upregulation of interleukin-35 biosynthetic process" EXACT [GOC:mah]
is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process
is_a: GO:0070750 ! regulation of interleukin-35 biosynthetic process
relationship: positively_regulates GO:0070749 ! interleukin-35 biosynthetic process

[Term]
id: GO:0070753
name: interleukin-35 production
namespace: biological_process
def: "The appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah]
synonym: "IL-35 production" EXACT [GOC:add]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0070754
name: regulation of interleukin-35 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of interleukin-35 production." [GOC:mah]
synonym: "regulation of IL-35 production" EXACT [GOC:add]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0070753 ! interleukin-35 production

[Term]
id: GO:0070755
name: negative regulation of interleukin-35 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-35 production." [GOC:mah]
synonym: "down regulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "down-regulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "downregulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "inhibition of interleukin-35 production" NARROW [GOC:mah]
synonym: "negative regulation of IL-35 production" EXACT [GOC:add]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0070754 ! regulation of interleukin-35 production
relationship: negatively_regulates GO:0070753 ! interleukin-35 production

[Term]
id: GO:0070756
name: positive regulation of interleukin-35 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of interleukin-35 production." [GOC:mah]
synonym: "activation of interleukin-35 production" NARROW [GOC:mah]
synonym: "positive regulation of IL-35 production" EXACT [GOC:add]
synonym: "stimulation of interleukin-35 production" NARROW [GOC:mah]
synonym: "up regulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "up-regulation of interleukin-35 production" EXACT [GOC:mah]
synonym: "upregulation of interleukin-35 production" EXACT [GOC:mah]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0070754 ! regulation of interleukin-35 production
relationship: positively_regulates GO:0070753 ! interleukin-35 production

[Term]
id: GO:0070757
name: interleukin-35-mediated signaling pathway
namespace: biological_process
def: "A series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor." [GOC:add, GOC:mah]
synonym: "IL-35-mediated signaling pathway" EXACT [GOC:add]
synonym: "interleukin-35-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0019221 ! cytokine-mediated signaling pathway

[Term]
id: GO:0070758
name: regulation of interleukin-35-mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35-mediated binding to a cell surface receptor." [GOC:mah]
synonym: "regulation of IL-35-mediated signaling pathway" EXACT [GOC:mah]
synonym: "regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway
relationship: regulates GO:0070757 ! interleukin-35-mediated signaling pathway

[Term]
id: GO:0070759
name: negative regulation of interleukin-35-mediated signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor." [GOC:mah]
synonym: "negative regulation of IL-35-mediated signaling pathway" EXACT [GOC:add]
synonym: "negative regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway
is_a: GO:0070758 ! regulation of interleukin-35-mediated signaling pathway
relationship: negatively_regulates GO:0070757 ! interleukin-35-mediated signaling pathway

[Term]
id: GO:0070760
name: positive regulation of interleukin-35-mediated signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor." [GOC:mah]
synonym: "positive regulation of IL-35-mediated signaling pathway" EXACT [GOC:add]
synonym: "positive regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway
is_a: GO:0070758 ! regulation of interleukin-35-mediated signaling pathway
relationship: positively_regulates GO:0070757 ! interleukin-35-mediated signaling pathway

[Term]
id: GO:0070761
name: pre-snoRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes." [GOC:BHF, GOC:mah, GOC:rl, PMID:17636026, PMID:17709390]
synonym: "pre-small nucleolar ribonucleoprotein complex" EXACT [GOC:rl]
is_a: GO:0030529 ! ribonucleoprotein complex

[Term]
id: GO:0070762
name: NDC1 complex
namespace: cellular_component
def: "A protein complex that forms part of the nuclear pore complex, and contains three transmembrane nucleoporins, encoded in S. cerevisiae by Ndc1p, Pom152p and Pom34p." [GOC:mah, PMID:19414609]
synonym: "NDC1 subcomplex" EXACT [PMID:19414609]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0005643 ! nuclear pore

[Term]
id: GO:0070763
name: Delta1 complex
namespace: cellular_component
def: "A protein complex that consists of homodimer of the Notch ligand Delta1." [PMID:12794186]
synonym: "Delta1 homodimer complex" EXACT [CORUM:3271]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070764
name: gamma-secretase-Delta1 complex
namespace: cellular_component
def: "A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex." [PMID:12794186]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070765
name: gamma-secretase complex
namespace: cellular_component
def: "A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein." [GOC:mah, PMID:15286082, PMID:15890777, PMID:17047368]
synonym: "CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)" NARROW [CORUM:142]
synonym: "gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)" NARROW [CORUM:130, CORUM:2891, CORUM:43, CORUM:45, CORUM:466]
synonym: "gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)" NARROW [CORUM:468]
synonym: "gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)" RELATED [CORUM:3128]
synonym: "gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)" NARROW [CORUM:467]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070766
name: endobrevin-synaptobrevin 2-alpha-SNAP-NSF-syntaxin-4 complex
namespace: cellular_component
def: "A SNARE complex that contains endobrevin (VAMP8), synaptobrevin 2 (VAMP2), alpha-SNAP, NSF, and syntaxin 4 (or orthologs thereof)." [PMID:8973549]
synonym: "SNARE complex (Stx4, Napa, Vamp3, Nsf, Vamp2)" NARROW [CORUM:1876]
synonym: "Stx4-Napa-Vamp3-Nsf-Vamp2 complex" NARROW [CORUM:1876]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070767
name: BRCA1-Rad51 complex
namespace: cellular_component
def: "A protein complex that contains BRCA1 and Rad 51, and is involved in the control of recombination and of genome integrity." [GOC:mah, PMID:9008167]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070768
name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Unc13 complex
namespace: cellular_component
def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Unc13b (or orthologs thereof)." [PMID:8999968]
synonym: "Snap25-Syt1-Unc13b-Vamp2-Stx1b2-Stx1a complex" NARROW [CORUM:1873]
synonym: "SNARE complex (Snap25, Syt1, Unc13b, Vamp2, Stx1b2, Stx1a)" NARROW [CORUM:1873]
is_a: GO:0031201 ! SNARE complex

[Term]
id: GO:0070769
name: alphaIIb-beta3 integrin-CIB complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin." [PMID:9030514]
synonym: "ITGA2B-ITGB3-CIB1 complex" NARROW [CORUM:2379]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070770
name: alphaIIb-beta3 integrin-CD47-FAK complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK." [PMID:9169439]
synonym: "ITGA2b-ITGB3-CD47-FAK complex" NARROW [CORUM:2896]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070771
name: alphaIIb-beta3 integrin-CD47-Src complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src." [PMID:9169439]
synonym: "ITGA2b-ITGB3-CD47-SRC complex" NARROW [CORUM:2377]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0070772
name: PAS complex
namespace: cellular_component
def: "A protein complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p." [PMID:18950639, PMID:19037259, PMID:19158662]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0005774 ! vacuolar membrane

[Term]
id: GO:0070773
name: protein N-terminal glutamine amidohydrolase activity
namespace: molecular_function
def: "Catalysis of the deamidation of an N-terminal glutamin residue of a protein." [PMID:19560421]
synonym: "NtQ-amidase activity" EXACT [PMID:19560421]
is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

[Term]
id: GO:0070774
name: phytoceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine." [GOC:pde, PMID:11356846]
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
is_a: GO:0017040 ! ceramidase activity

[Term]
id: GO:0070775
name: H3 histone acetyltransferase complex
namespace: cellular_component
def: "A multisubunit complex that catalyzes the acetylation of histone H3." [GOC:mah]
synonym: "H3 HAT complex" EXACT [GOC:mah]
is_a: GO:0000123 ! histone acetyltransferase complex

[Term]
id: GO:0070776
name: MOZ/MORF histone acetyltransferase complex
namespace: cellular_component
def: "A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3." [PMID:18794358]
is_a: GO:0070775 ! H3 histone acetyltransferase complex

[Term]
id: GO:0070777
name: D-aspartate transport
namespace: biological_process
def: "The directed movement of D-aspartate, the D-enantiomer of the anion of (2R)-2-aminobutanedioic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [ChEBI:17364, GOC:mah, GOC:rph]
is_a: GO:0015810 ! aspartate transport
is_a: GO:0042940 ! D-amino acid transport

[Term]
id: GO:0070778
name: L-aspartate transport
namespace: biological_process
def: "The directed movement of L-aspartate, the L-enantiomer of the anion of (2R)-2-aminobutanedioic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [ChEBI:17053, GOC:mah]
is_a: GO:0015807 ! L-amino acid transport
is_a: GO:0015810 ! aspartate transport

[Term]
id: GO:0070779
name: D-aspartate import
namespace: biological_process
def: "The directed movement of D-aspartate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:rph]
subset: gosubset_prok
synonym: "D-aspartate uptake" EXACT [GOC:mah]
is_a: GO:0043090 ! amino acid import
is_a: GO:0070777 ! D-aspartate transport

[Term]
id: GO:0070780
name: dihydrosphingosine-1-phosphate phosphatase activity
namespace: molecular_function
def: "Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate." [GOC:pde, PMID:12815058]
synonym: "dihydrosphingosine-1-phosphate phosphohydrolase activity" EXACT [GOC:mah]
synonym: "sphinganine-1-phosphate phosphatase activity" EXACT [GOC:mah]
xref: MetaCyc:RXN3DJ-25
is_a: GO:0016791 ! phosphatase activity

[Term]
id: GO:0070781
name: response to biotin
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus." [GOC:sl]
synonym: "response to Bios IIB" EXACT [GOC:sl]
synonym: "response to coenzyme R" EXACT [GOC:sl]
synonym: "response to vitamin B7" EXACT [GOC:sl]
synonym: "response to vitamin H" EXACT [GOC:sl]
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0070782
name: phosphatidylserine exposure on apoptotic cell surface
namespace: biological_process
def: "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an \"eat-me\" signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity." [GOC:mah, GOC:rk, PMID:11536005]
synonym: "externalization of phosphatidylserine" EXACT [GOC:rk]
is_a: GO:0017121 ! phospholipid scrambling
relationship: part_of GO:0006915 ! apoptosis

[Term]
id: GO:0070783
name: growth of unicellular organism as a thread of attached cells
namespace: biological_process
def: "A filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions." [GOC:mah, GOC:mcc]
subset: goslim_candida
is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms

[Term]
id: GO:0070784
name: regulation of growth of unicellular organism as a thread of attached cells
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah]
is_a: GO:0010570 ! regulation of filamentous growth
relationship: regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells

[Term]
id: GO:0070785
name: negative regulation of growth of unicellular organism as a thread of attached cells
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah]
is_a: GO:0060258 ! negative regulation of filamentous growth
is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells
relationship: negatively_regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells

[Term]
id: GO:0070786
name: positive regulation of growth of unicellular organism as a thread of attached cells
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah]
is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells
is_a: GO:0090033 ! positive regulation of filamentous growth
relationship: positively_regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells

[Term]
id: GO:0070787
name: conidiophore development
namespace: biological_process
def: "The process whose specific outcome is the progression of the conidiophore over time, from its formation to the mature structure. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [PMID:9529886]
is_a: GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0070788
name: conidiophore stalk development
namespace: biological_process
def: "The process whose specific outcome is the progression of the conidiophore stalk over time, from its formation to the mature structure. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [PMID:9529886]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0070787 ! conidiophore development

[Term]
id: GO:0070789
name: metula development
namespace: biological_process
def: "The process whose specific outcome is the progression of metulae over time, from its formation to the mature structure. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [PMID:9529886]
synonym: "development of primary sterigmata" EXACT [PMID:9529886]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0070787 ! conidiophore development

[Term]
id: GO:0070790
name: phialide development
namespace: biological_process
def: "The process whose specific outcome is the progression of phialides over time, from its formation to the mature structure. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. Chains of conidia, or asexual spores, develop from the phialide tips." [PMID:9529886]
synonym: "development of secondary sterigmata" EXACT [PMID:9529886]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0070787 ! conidiophore development

[Term]
id: GO:0070791
name: cleistothecium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cleistothecium over time, from its formation to the mature structure. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [ISBN:0471522295, PMID:17446882]
is_a: GO:0000909 ! sporocarp development involved in sexual reproduction

[Term]
id: GO:0070792
name: Hulle cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of Hulle cells over time, from their formation to the mature structures. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [PMID:19210625]
synonym: "Huelle cell development" EXACT [GOC:mah]
synonym: "Hulle cell formation" NARROW [PMID:19210625]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0070791 ! cleistothecium development

[Term]
id: GO:0070793
name: regulation of conidiophore development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah]
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0070787 ! conidiophore development

[Term]
id: GO:0070794
name: negative regulation of conidiophore development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah]
is_a: GO:0070793 ! regulation of conidiophore development
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
relationship: negatively_regulates GO:0070787 ! conidiophore development

[Term]
id: GO:0070795
name: positive regulation of conidiophore development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah]
is_a: GO:0070793 ! regulation of conidiophore development
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
relationship: positively_regulates GO:0070787 ! conidiophore development

[Term]
id: GO:0070796
name: regulation of cleistothecium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah]
is_a: GO:0031155 ! regulation of fruiting body development
relationship: regulates GO:0070791 ! cleistothecium development

[Term]
id: GO:0070797
name: negative regulation of cleistothecium development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah]
is_a: GO:0070796 ! regulation of cleistothecium development
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
relationship: negatively_regulates GO:0070791 ! cleistothecium development

[Term]
id: GO:0070798
name: positive regulation of cleistothecium development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah]
is_a: GO:0070796 ! regulation of cleistothecium development
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
relationship: positively_regulates GO:0070791 ! cleistothecium development

[Term]
id: GO:0070799
name: regulation of conidiophore stalk development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah]
is_a: GO:0070793 ! regulation of conidiophore development
relationship: regulates GO:0070788 ! conidiophore stalk development

[Term]
id: GO:0070800
name: negative regulation of conidiophore stalk development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0070799 ! regulation of conidiophore stalk development
relationship: negatively_regulates GO:0070788 ! conidiophore stalk development

[Term]
id: GO:0070801
name: positive regulation of conidiophore stalk development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0070799 ! regulation of conidiophore stalk development
relationship: positively_regulates GO:0070788 ! conidiophore stalk development

[Term]
id: GO:0070802
name: regulation of metula development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah]
is_a: GO:0060284 ! regulation of cell development
is_a: GO:0070793 ! regulation of conidiophore development
relationship: regulates GO:0070789 ! metula development

[Term]
id: GO:0070803
name: negative regulation of metula development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0070802 ! regulation of metula development
relationship: negatively_regulates GO:0070789 ! metula development

[Term]
id: GO:0070804
name: positive regulation of metula development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0070802 ! regulation of metula development
relationship: positively_regulates GO:0070789 ! metula development

[Term]
id: GO:0070805
name: regulation of phialide development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah]
is_a: GO:0060284 ! regulation of cell development
is_a: GO:0070793 ! regulation of conidiophore development
relationship: regulates GO:0070790 ! phialide development

[Term]
id: GO:0070806
name: negative regulation of phialide development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0070805 ! regulation of phialide development
relationship: negatively_regulates GO:0070790 ! phialide development

[Term]
id: GO:0070807
name: positive regulation of phialide development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0070805 ! regulation of phialide development
relationship: positively_regulates GO:0070790 ! phialide development

[Term]
id: GO:0070808
name: regulation of Hulle cell development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah]
is_a: GO:0060284 ! regulation of cell development
is_a: GO:0070796 ! regulation of cleistothecium development
relationship: regulates GO:0070792 ! Hulle cell development

[Term]
id: GO:0070809
name: negative regulation of Hulle cell development
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0070808 ! regulation of Hulle cell development
relationship: negatively_regulates GO:0070792 ! Hulle cell development

[Term]
id: GO:0070810
name: positive regulation of Hulle cell development
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0070808 ! regulation of Hulle cell development
relationship: positively_regulates GO:0070792 ! Hulle cell development

[Term]
id: GO:0070811
name: glycerol-2-phosphate transport
namespace: biological_process
def: "The directed movement of glycerol-2-phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore. Glycerol-2-phosphate is a phosphoric monoester of glycerol." [GOC:mah]
subset: gosubset_prok
is_a: GO:0015793 ! glycerol transport

[Term]
id: GO:0070812
name: glycerol-2-phosphate-transporting ATPase activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-2-phosphate(out) = ADP + phosphate + glycerol-2-phosphate(in)." [GOC:mah]
comment: Consider also annotating to the molecular function term 'ATP binding ; GO:0005524'.
subset: gosubset_prok
is_a: GO:0015168 ! glycerol transmembrane transporter activity
is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances

[Term]
id: GO:0070813
name: hydrogen sulfide metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving hydrogen sulfide, H2S." [ChEBI:16136, GOC:mah]
synonym: "hydrogen sulfide metabolism" EXACT [GOC:mah]
synonym: "hydrogen sulphide metabolic process" EXACT [GOC:mah]
synonym: "hydrogen sulphide metabolism" EXACT [GOC:mah]
is_a: GO:0006790 ! sulfur metabolic process

[Term]
id: GO:0070814
name: hydrogen sulfide biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S." [ChEBI:16136, GOC:mah]
synonym: "hydrogen sulfide anabolism" EXACT [GOC:mah]
synonym: "hydrogen sulfide biosynthesis" EXACT [GOC:mah]
synonym: "hydrogen sulfide formation" EXACT [GOC:mah]
synonym: "hydrogen sulfide synthesis" EXACT [GOC:mah]
synonym: "hydrogen sulphide biosynthesis" EXACT [GOC:mah]
synonym: "hydrogen sulphide biosynthetic process" EXACT [GOC:mah]
is_a: GO:0044272 ! sulfur compound biosynthetic process
is_a: GO:0070813 ! hydrogen sulfide metabolic process

[Term]
id: GO:0070815
name: peptidyl-lysine 5-dioxygenase activity
namespace: molecular_function
def: "Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2." [PMID:19574390]
synonym: "lysine hydroxylase activity" BROAD [GOC:mah]
synonym: "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD [GOC:mah]
synonym: "lysine-2-oxoglutarate dioxygenase activity" BROAD [GOC:mah]
synonym: "lysyl hydroxylase activity" BROAD [GOC:mah]
synonym: "peptide-lysine 5-dioxygenase activity" EXACT [GOC:mah]
synonym: "peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity" EXACT [EC:1.14.11.4, GOC:mah]
synonym: "peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity" EXACT [EC:1.14.11.4, GOC:mah]
synonym: "protein lysine hydroxylase activity" EXACT [GOC:mah]
is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

[Term]
id: GO:0070816
name: phosphorylation of RNA polymerase II C-terminal domain
namespace: biological_process
alt_id: GO:0016245
def: "The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683]
synonym: "CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:mah]
synonym: "generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:krc]
synonym: "generation of II(0) form of RNA polymerase II" EXACT [GOC:krc]
synonym: "hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:krc]
xref: Reactome:448704 "RNA Pol II CTD phosphorylation and interaction with CE"
xref: Reactome:469826 "RNA Pol II CTD phosphorylation and interaction with CE"
xref: Reactome:487519 "RNA Pol II CTD phosphorylation and interaction with CE"
xref: Reactome:507480 "RNA Pol II CTD phosphorylation and interaction with CE"
xref: Reactome:517464 "RNA Pol II CTD phosphorylation and interaction with CE"
xref: Reactome:526337 "RNA Pol II CTD phosphorylation and interaction with CE"
xref: Reactome:531170 "RNA Pol II CTD phosphorylation and interaction with CE"
xref: Reactome:536545 "RNA Pol II CTD phosphorylation and interaction with CE"
xref: Reactome:542266 "RNA Pol II CTD phosphorylation and interaction with CE"
xref: Reactome:547612 "RNA Pol II CTD phosphorylation and interaction with CE"
xref: Reactome:552216 "RNA Pol II CTD phosphorylation and interaction with CE"
xref: Reactome:557806 "RNA Pol II CTD phosphorylation and interaction with CE"
xref: Reactome:568423 "RNA Pol II CTD phosphorylation and interaction with CE"
xref: Reactome:581625 "RNA Pol II CTD phosphorylation and interaction with CE"
xref: Reactome:592522 "RNA Pol II CTD phosphorylation and interaction with CE"
xref: Reactome:595357 "RNA Pol II CTD phosphorylation and interaction with CE"
xref: Reactome:77075 "RNA Pol II CTD phosphorylation and interaction with CE"
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0006468 ! protein amino acid phosphorylation

[Term]
id: GO:0070817
name: P-TEFb-cap methyltransferase complex localization
namespace: biological_process
def: "Any process by which the P-TEFb-cap methyltransferase complex is transported to, or maintained in, a specific location." [GOC:mah]
synonym: "establishment and maintenance of P-TEFb-cap methyltransferase complex localization" EXACT [GOC:MAH]
is_a: GO:0034629 ! cellular protein complex localization

[Term]
id: GO:0070818
name: protoporphyrinogen oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: protoporphyrinogen-IX + acceptor = protoporphyrin-IX + reduced acceptor." [EC:1.3.3.4, GOC:mah, PMID:19583219]
subset: gosubset_prok
synonym: "protoporphyrinogen IX oxidase activity" EXACT [EC:1.3.3.4]
synonym: "protoporphyrinogen-IX oxidase activity" EXACT [EC:1.3.3.4]
synonym: "protoporphyrinogenase activity" EXACT [EC:1.3.3.4]
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0070819
name: menaquinone-dependent protoporphyrinogen oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: protoporphyrinogen-IX + menaquinone = protoporphyrin-IX + reduced menaquinone." [GOC:mah, PMID:19583219]
subset: gosubset_prok
synonym: "protoporphyrinogen-IX:menaquinone oxidoreductase activity" EXACT [GOC:mah]
is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor
is_a: GO:0070818 ! protoporphyrinogen oxidase activity

[Term]
id: GO:0070820
name: tertiary granule
namespace: cellular_component
def: "A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036]
is_a: GO:0030141 ! secretory granule

[Term]
id: GO:0070821
name: tertiary granule membrane
namespace: cellular_component
def: "The lipid bilayer surrounding a tertiary granule." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036]
is_a: GO:0030667 ! secretory granule membrane
relationship: part_of GO:0070820 ! tertiary granule

[Term]
id: GO:0070822
name: Sin3-type complex
namespace: cellular_component
def: "Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778]
is_a: GO:0000118 ! histone deacetylase complex
relationship: part_of GO:0000790 ! nuclear chromatin

[Term]
id: GO:0070823
name: HDA1 complex
namespace: cellular_component
def: "A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p." [GOC:dgf, GOC:mah, PMID:11287668, PMID:8663039]
is_a: GO:0000118 ! histone deacetylase complex
is_a: GO:0000790 ! nuclear chromatin

[Term]
id: GO:0070824
name: SHREC complex
namespace: cellular_component
def: "A histone deacetylase complex that contains a core of four proteins -- Clr1, Clr2, Clr3, and Mit1 in fission yeast -- and localizes to all heterochromatic regions in the genome as well as some euchromatic sites. The complex is involved in regulating nucleosome positioning to assemble higher-order chromatin structures." [GOC:mah, PMID:17289569]
is_a: GO:0000118 ! histone deacetylase complex
is_a: GO:0017053 ! transcriptional repressor complex

[Term]
id: GO:0070825
name: micropyle
namespace: cellular_component
def: "An external encapsulating structure part of the chorion. A single cone-shaped specialization that forms an opening in the chorion that allows sperm entry into the egg prior to fertilization." [GOC:cvs, GOC:mah, PMID:18649270]
is_a: GO:0044462 ! external encapsulating structure part
relationship: part_of GO:0042600 ! chorion

[Term]
id: GO:0070826
name: paraferritin complex
namespace: cellular_component
def: "A cytoplasmic protein complex that contains integrin, mobilferrin and a flavin monooxygenase, is capable of reducing Fe(III) to Fe(II) utilizing NADPH, and is involved in iron transport. Fe(II) is required in the cell as the substrate for ferrochelatase in the synthesis of heme." [GOC:mah, GOC:rph, PMID:11842004, PMID:8639593]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0070827
name: chromatin maintenance
namespace: biological_process
def: "The chromatin organization process by which chromatin is preserved in a stable functional or structural state." [GOC:mah]
is_a: GO:0006325 ! chromatin organization
is_a: GO:0043954 ! cellular component maintenance

[Term]
id: GO:0070828
name: heterochromatin organization
namespace: biological_process
def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin." [GOC:mah]
is_a: GO:0006325 ! chromatin organization

[Term]
id: GO:0070829
name: heterochromatin maintenance
namespace: biological_process
def: "The chromatin organization process by which heterochromatin is preserved in a stable functional or structural state." [GOC:mah]
is_a: GO:0070827 ! chromatin maintenance
is_a: GO:0070828 ! heterochromatin organization

[Term]
id: GO:0070830
name: tight junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet." [GOC:mah]
synonym: "tight junction formation" EXACT [GOC:mah]
is_a: GO:0007043 ! cell-cell junction assembly
relationship: part_of GO:0043297 ! apical junction assembly

[Term]
id: GO:0070831
name: basement membrane assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue." [GOC:mah]
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0070832
name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that begins with three consecutive N-methylation steps that are carried out on phospho-bases, phosphoethanolamine, phospho-N-methylethanolamine, and phospho-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-2]
xref: MetaCyc:PWY4FS-2
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process

[Term]
id: GO:0070833
name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that begins with an initial N-methylation with phospho-base phosphoethanolamine, followed by two downstream N-methylations on phosphatidyl-bases, phosphatidyl-N-methylethanolamine and phosphatidyl-N-dimethylethanolamine. The process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-3]
xref: MetaCyc:PWY4FS-3
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process

[Term]
id: GO:0070834
name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine
namespace: biological_process
def: "The phosphatidylcholine biosynthetic process that begins with two N-methylations with phospho-base phosphoethanolamine and phospho-N-methylethanolamine, followed by a downstream N-methylation on phosphatidyl-base phosphatidyl-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-4]
xref: MetaCyc:PWY4FS-4
is_a: GO:0006656 ! phosphatidylcholine biosynthetic process

[Term]
id: GO:0070835
name: chromium ion transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of chromium (Cr) ions from one side of a membrane to the other." [GOC:mah]
is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity
is_a: GO:0046915 ! transition metal ion transmembrane transporter activity

[Term]
id: GO:0070836
name: caveola assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane." [GOC:BHF, GOC:mah, GOC:vk, PMID:12633858]
synonym: "caveola formation" EXACT [GOC:mah]
synonym: "caveolar biogenesis" RELATED [PMID:12633858]
is_a: GO:0001765 ! membrane raft assembly

[Term]
id: GO:0070837
name: dehydroascorbic acid transport
namespace: biological_process
def: "The directed movement of dehydroascorbate into, out of, within or between cells by means of some external agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C." [GOC:sl]
synonym: "dehydroascorbate transport" EXACT [GOC:sl]
is_a: GO:0051180 ! vitamin transport

[Term]
id: GO:0070838
name: divalent metal ion transport
namespace: biological_process
def: "The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mah]
subset: gosubset_prok
is_a: GO:0015674 ! di-, tri-valent inorganic cation transport
is_a: GO:0030001 ! metal ion transport

[Term]
id: GO:0070839
name: divalent metal ion export
namespace: biological_process
def: "The directed movement of divalent metal cations, any metal ion with a +2 electric charge, out of a cell or organelle." [GOC:mah]
is_a: GO:0070838 ! divalent metal ion transport

[Term]
id: GO:0070840
name: dynein complex binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:BHF, GOC:mah]
is_a: GO:0032403 ! protein complex binding

[Term]
id: GO:0070841
name: inclusion body assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:mah]
is_a: GO:0022607 ! cellular component assembly

[Term]
id: GO:0070842
name: aggresome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein." [GOC:BHF, GOC:rl, PMID:14675537]
is_a: GO:0070841 ! inclusion body assembly

[Term]
id: GO:0070843
name: misfolded protein transport
namespace: biological_process
def: "The directed movement of misfolded proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537]
is_a: GO:0006886 ! intracellular protein transport

[Term]
id: GO:0070844
name: polyubiquitinated protein transport
namespace: biological_process
def: "The directed movement of polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537]
synonym: "polyubiquitylated protein transport" EXACT [GOC:mah]
is_a: GO:0006886 ! intracellular protein transport

[Term]
id: GO:0070845
name: polyubiquitinated misfolded protein transport
namespace: biological_process
def: "The directed movement of misfolded polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537]
synonym: "misfolded polyubiquitinated protein transport" RELATED [GOC:mah]
synonym: "polyubiquitylated misfolded protein transport" EXACT [GOC:mah]
is_a: GO:0070843 ! misfolded protein transport
is_a: GO:0070844 ! polyubiquitinated protein transport

[Term]
id: GO:0070846
name: Hsp90 deacetylation
namespace: biological_process
def: "The modification of an Hsp90 protein by removal of acetyl groups." [GOC:BHF, GOC:mah]
is_a: GO:0006476 ! protein amino acid deacetylation

[Term]
id: GO:0070847
name: core mediator complex
namespace: cellular_component
def: "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]
synonym: "C mediator complex" EXACT [PMID:17870225]
synonym: "S mediator complex" EXACT [PMID:17043218]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme

[Term]
id: GO:0070848
name: response to growth factor stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0070849
name: response to epidermal growth factor stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:BHF, GOC:mah]
synonym: "response to EGF stimulus" EXACT [GOC:mah]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0070848 ! response to growth factor stimulus

[Term]
id: GO:0070850
name: TACC/TOG complex
namespace: cellular_component
def: "A protein complex that contains the transforming acidic coiled coil (TACC) protein and the TOG protein (Mia1p/Alp7p and Alp14, respectively, in fission yeast), and is involved in microtubule array remodeling as cells progress through the cell cycle. The TACC/TOG complex is conserved in eukaryotes, associates with microtubules, and shuttles between the nucleus and the cytoplasm during interphase." [GOC:mah, GOC:vw, PMID:19606211]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0070851
name: growth factor receptor binding
namespace: molecular_function
def: "Interacting selectively with a growth factor receptor." [GOC:mah]
is_a: GO:0005102 ! receptor binding

[Term]
id: GO:0070852
name: cell body fiber
namespace: cellular_component
def: "A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches." [GOC:dos, GOC:mah]
synonym: "cell body fibre" EXACT []
synonym: "primary neurite" RELATED [GOC:dos, GOC:mah]
is_a: GO:0043005 ! neuron projection

[Term]
id: GO:0070853
name: myosin VI binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:15473855]
is_a: GO:0017022 ! myosin binding

[Term]
id: GO:0070854
name: myosin VI heavy chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a heavy chain of a myosin VI complex." [GOC:sart]
is_a: GO:0032036 ! myosin heavy chain binding
is_a: GO:0070853 ! myosin VI binding

[Term]
id: GO:0070855
name: myosin VI head/neck binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the head/neck region of a myosin VI heavy chain." [GOC:sart]
is_a: GO:0032028 ! myosin head/neck binding
is_a: GO:0070854 ! myosin VI heavy chain binding

[Term]
id: GO:0070856
name: myosin VI light chain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a light chain of a myosin VI complex." [GOC:sart]
is_a: GO:0032027 ! myosin light chain binding
is_a: GO:0070853 ! myosin VI binding

[Term]
id: GO:0070857
name: regulation of bile acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah]
synonym: "regulation of bile acid anabolism" EXACT [GOC:mah]
synonym: "regulation of bile acid biosynthesis" EXACT [GOC:mah]
synonym: "regulation of bile acid formation" EXACT [GOC:mah]
synonym: "regulation of bile acid synthesis" EXACT [GOC:mah]
is_a: GO:0010565 ! regulation of cellular ketone metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process
relationship: regulates GO:0006699 ! bile acid biosynthetic process

[Term]
id: GO:0070858
name: negative regulation of bile acid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah]
synonym: "down regulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "downregulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of bile acid biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of bile acid anabolism" EXACT [GOC:mah]
synonym: "negative regulation of bile acid biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of bile acid formation" EXACT [GOC:mah]
synonym: "negative regulation of bile acid synthesis" EXACT [GOC:mah]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0070857 ! regulation of bile acid biosynthetic process
relationship: negatively_regulates GO:0006699 ! bile acid biosynthetic process

[Term]
id: GO:0070859
name: positive regulation of bile acid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah]
synonym: "activation of bile acid biosynthetic process" NARROW [GOC:mah]
synonym: "positive regulation of bile acid anabolism" EXACT [GOC:mah]
synonym: "positive regulation of bile acid biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of bile acid formation" EXACT [GOC:mah]
synonym: "positive regulation of bile acid synthesis" EXACT [GOC:mah]
synonym: "stimulation of bile acid biosynthetic process" NARROW [GOC:mah]
synonym: "up regulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "up-regulation of bile acid biosynthetic process" EXACT [GOC:mah]
synonym: "upregulation of bile acid biosynthetic process" EXACT [GOC:mah]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0070857 ! regulation of bile acid biosynthetic process
relationship: positively_regulates GO:0006699 ! bile acid biosynthetic process

[Term]
id: GO:0070860
name: RNA polymerase I core factor complex
namespace: cellular_component
def: "A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p." [PMID:8702872]
comment: Note that, although this complex can be considered analogous to the mammalian transcription factor SL complex, the core factor complex does not include TBP, whereas SL1 does.
is_a: GO:0000120 ! RNA polymerase I transcription factor complex

[Term]
id: GO:0070861
name: regulation of protein exit from endoplasmic reticulum
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah]
synonym: "regulation of protein exit from ER" EXACT [GOC:mah]
synonym: "regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "regulation of protein export from ER" EXACT [GOC:mah]
is_a: GO:0033157 ! regulation of intracellular protein transport
relationship: regulates GO:0032527 ! protein exit from endoplasmic reticulum

[Term]
id: GO:0070862
name: negative regulation of protein exit from endoplasmic reticulum
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah]
synonym: "down regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "down-regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "downregulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "inhibition of protein exit from endoplasmic reticulum" NARROW [GOC:mah]
synonym: "negative regulation of protein exit from ER" EXACT [GOC:mah]
synonym: "negative regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "negative regulation of protein export from ER" EXACT [GOC:mah]
is_a: GO:0032387 ! negative regulation of intracellular transport
is_a: GO:0051224 ! negative regulation of protein transport
is_a: GO:0070861 ! regulation of protein exit from endoplasmic reticulum
relationship: negatively_regulates GO:0032527 ! protein exit from endoplasmic reticulum

[Term]
id: GO:0070863
name: positive regulation of protein exit from endoplasmic reticulum
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum." [GOC:mah]
synonym: "activation of protein exit from endoplasmic reticulum" NARROW [GOC:mah]
synonym: "positive regulation of protein exit from ER" EXACT [GOC:mah]
synonym: "positive regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "positive regulation of protein export from ER" EXACT [GOC:mah]
synonym: "stimulation of protein exit from endoplasmic reticulum" NARROW [GOC:mah]
synonym: "up regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "up-regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
synonym: "upregulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah]
is_a: GO:0032388 ! positive regulation of intracellular transport
is_a: GO:0051222 ! positive regulation of protein transport
is_a: GO:0070861 ! regulation of protein exit from endoplasmic reticulum
relationship: positively_regulates GO:0032527 ! protein exit from endoplasmic reticulum

[Term]
id: GO:0070864
name: sperm individualization complex
namespace: cellular_component
def: "A macromolecular complex that cytoskeletal components and part of the cell membrane, forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst." [GOC:sart, PMID:10588662, PMID:9550716]
is_a: GO:0032991 ! macromolecular complex
is_a: GO:0044464 ! cell part

[Term]
id: GO:0070865
name: investment cone
namespace: cellular_component
def: "A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization." [GOC:sart, PMID:15829565, PMID:9550716]
synonym: "F-actin cone" EXACT [PMID:15829565]
is_a: GO:0044430 ! cytoskeletal part
relationship: part_of GO:0070864 ! sperm individualization complex

[Term]
id: GO:0070866
name: sterol-dependent protein binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) in the presence of sterols." [GOC:ecd]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0070867
name: mating projection tip membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding a mating projection tip." [GOC:mah]
is_a: GO:0044459 ! plasma membrane part
relationship: part_of GO:0043332 ! mating projection tip

[Term]
id: GO:0070868
name: heterochromatin organization involved in chromatin silencing
namespace: biological_process
def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah]
is_a: GO:0070828 ! heterochromatin organization
relationship: part_of GO:0006342 ! chromatin silencing

[Term]
id: GO:0070869
name: heterochromatin formation involved in chromatin silencing
namespace: biological_process
def: "Any process that results in the assembly of chromatin into heterochromatin and contributes to chromatin silencing." [GOC:mah]
is_a: GO:0031507 ! heterochromatin formation
is_a: GO:0070868 ! heterochromatin organization involved in chromatin silencing

[Term]
id: GO:0070870
name: heterochromatin maintenance involved in chromatin silencing
namespace: biological_process
def: "A chromatin organization process by which heterochromatin is preserved in a stable functional or structural state, and that contributes to chromatin silencing." [GOC:mah]
is_a: GO:0070829 ! heterochromatin maintenance
is_a: GO:0070868 ! heterochromatin organization involved in chromatin silencing

[Term]
id: GO:0070871
name: cell wall organization involved in conjugation with cellular fusion
namespace: biological_process
def: "A process of cell wall organization that contributes to conjugation with cellular fusion." [GOC:mah]
is_a: GO:0007047 ! cellular cell wall organization
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0070872
name: plasma membrane organization involved in conjugation with cellular fusion
namespace: biological_process
def: "A process of plasma membrane organization that contributes to conjugation with cellular fusion." [GOC:mah]
is_a: GO:0007009 ! plasma membrane organization
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0070873
name: regulation of glycogen metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah]
synonym: "regulation of glycogen metabolism" EXACT [GOC:mah]
is_a: GO:0010906 ! regulation of glucose metabolic process
is_a: GO:0032881 ! regulation of polysaccharide metabolic process
is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy
relationship: regulates GO:0005977 ! glycogen metabolic process

[Term]
id: GO:0070874
name: negative regulation of glycogen metabolic process
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah]
synonym: "negative regulation of glycogen metabolism" EXACT [GOC:mah]
is_a: GO:0010605 ! negative regulation of macromolecule metabolic process
is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process
is_a: GO:0070873 ! regulation of glycogen metabolic process
relationship: negatively_regulates GO:0005977 ! glycogen metabolic process

[Term]
id: GO:0070875
name: positive regulation of glycogen metabolic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah]
synonym: "positive regulation of glycogen metabolism" EXACT [GOC:mah]
is_a: GO:0010604 ! positive regulation of macromolecule metabolic process
is_a: GO:0010907 ! positive regulation of glucose metabolic process
is_a: GO:0070873 ! regulation of glycogen metabolic process
relationship: positively_regulates GO:0005977 ! glycogen metabolic process

[Term]
id: GO:0070876
name: SOSS complex
namespace: cellular_component
def: "A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80." [PMID:19683501]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070877
name: microprocessor complex
namespace: cellular_component
def: "A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs." [PMID:16963499, PMID:17159994]
is_a: GO:0043234 ! protein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0070878
name: pri-miRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding." [PMID:15531877, PMID:15574589]
synonym: "primary microRNA binding" EXACT [PMID:15531877, PMID:15574589]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0070879
name: fungal-type cell wall beta-glucan metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:mah]
synonym: "fungal-type cell wall beta-glucan metabolism" EXACT [GOC:mah]
is_a: GO:0034406 ! cell wall beta-glucan metabolic process
relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis

[Term]
id: GO:0070880
name: fungal-type cell wall beta-glucan biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:mah]
synonym: "fungal-type cell wall beta-glucan anabolism" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-glucan biosynthesis" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-glucan formation" EXACT [GOC:mah]
synonym: "fungal-type cell wall beta-glucan synthesis" EXACT [GOC:mah]
is_a: GO:0051274 ! beta-glucan biosynthetic process
is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process
is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process

[Term]
id: GO:0070881
name: regulation of proline transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of proline transport." [GOC:mah]
is_a: GO:0051955 ! regulation of amino acid transport
relationship: regulates GO:0015824 ! proline transport

[Term]
id: GO:0070882
name: cellular cell wall organization or biogenesis
namespace: biological_process
def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall." [GOC:mah]
subset: goslim_pombe
subset: gosubset_prok
synonym: "cell wall organization or biogenesis at cellular level" EXACT [GOC:mah]
synonym: "cellular cell wall organisation or biogenesis" EXACT [GOC:mah]
is_a: GO:0009987 ! cellular process
is_a: GO:0071554 ! cell wall organization or biogenesis

[Term]
id: GO:0070883
name: pre-miRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA." [PMID:18951094]
synonym: "precursor microRNA binding" EXACT [PMID:18951094]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0070884
name: regulation of calcineurin-NFAT signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway." [GOC:ai]
synonym: "regulation of calcineurin-NFAT signalling pathway" EXACT [GOC:mah]
is_a: GO:0050848 ! regulation of calcium-mediated signaling
relationship: regulates GO:0033173 ! calcineurin-NFAT signaling pathway

[Term]
id: GO:0070885
name: negative regulation of calcineurin-NFAT signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway." [GOC:mah]
synonym: "down regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah]
synonym: "down-regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah]
synonym: "downregulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah]
synonym: "inhibition of calcineurin-NFAT signaling pathway" NARROW [GOC:mah]
synonym: "negative regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah]
is_a: GO:0050849 ! negative regulation of calcium-mediated signaling
is_a: GO:0070884 ! regulation of calcineurin-NFAT signaling pathway
relationship: negatively_regulates GO:0033173 ! calcineurin-NFAT signaling pathway

[Term]
id: GO:0070886
name: positive regulation of calcineurin-NFAT signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway." [GOC:mah]
synonym: "activation of calcineurin-NFAT signaling pathway" NARROW [GOC:mah]
synonym: "positive regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah]
synonym: "stimulation of calcineurin-NFAT signaling pathway" NARROW [GOC:mah]
synonym: "up regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah]
synonym: "up-regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah]
synonym: "upregulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah]
is_a: GO:0050850 ! positive regulation of calcium-mediated signaling
is_a: GO:0070884 ! regulation of calcineurin-NFAT signaling pathway
relationship: positively_regulates GO:0033173 ! calcineurin-NFAT signaling pathway

[Term]
id: GO:0070887
name: cellular response to chemical stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah]
is_a: GO:0042221 ! response to chemical stimulus
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0070888
name: E-box binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes in neurons, muscle and other tissues." [GOC:BHF, GOC:vk, PMID:11812799]
synonym: "E-box promoter binding" EXACT [GOC:vk]
is_a: GO:0010843 ! promoter binding

[Term]
id: GO:0070889
name: platelet alpha granule organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets." [GOC:rph, PMID:16123220]
synonym: "platelet alpha granule organization and biogenesis" RELATED [GOC:mah]
synonym: "platelet alpha-granule organization" EXACT [GOC:mah]
is_a: GO:0033363 ! secretory granule organization

[Term]
id: GO:0070890
name: sodium-dependent L-ascorbate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in)." [GOC:mah, PMID:18094143]
is_a: GO:0015229 ! L-ascorbic acid transporter activity
is_a: GO:0015370 ! solute:sodium symporter activity

[Term]
id: GO:0070891
name: lipoteichoic acid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with lipoteichoic acid." [GOC:add, PMID:14665680]
is_a: GO:0005488 ! binding

[Term]
id: GO:0070892
name: lipoteichoic acid receptor activity
namespace: molecular_function
def: "Combining with lipoteichoic acid to initiate a change in cell activity." [GOC:add, PMID:14665680]
is_a: GO:0008329 ! pattern recognition receptor activity
is_a: GO:0070891 ! lipoteichoic acid binding

[Term]
id: GO:0070893
name: transposon integration
namespace: biological_process
def: "Any process by which a transposable element is incorporated into another DNA molecule such as a chromosome." [GOC:jp, PMID:10882723]
is_a: GO:0015074 ! DNA integration
is_a: GO:0032196 ! transposition

[Term]
id: GO:0070894
name: regulation of transposon integration
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of regulation of transposon integration, a process by which a transposable element is incorporated into another DNA molecule." [GOC:mah]
is_a: GO:0010528 ! regulation of transposition
is_a: GO:0051052 ! regulation of DNA metabolic process
relationship: regulates GO:0070893 ! transposon integration

[Term]
id: GO:0070895
name: negative regulation of transposon integration
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of transposon integration, a process by which a transposable element is incorporated into another DNA molecule." [GOC:mah]
synonym: "down regulation of transposon integration" EXACT [GOC:mah]
synonym: "down-regulation of transposon integration" EXACT [GOC:mah]
synonym: "downregulation of transposon integration" EXACT [GOC:mah]
synonym: "inhibition of transposon integration" NARROW [GOC:mah]
is_a: GO:0010529 ! negative regulation of transposition
is_a: GO:0051053 ! negative regulation of DNA metabolic process
is_a: GO:0070894 ! regulation of transposon integration
relationship: negatively_regulates GO:0070893 ! transposon integration

[Term]
id: GO:0070896
name: positive regulation of transposon integration
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transposon integration, a process by which a transposable element is incorporated into another DNA molecule." [GOC:mah]
synonym: "activation of transposon integration" NARROW [GOC:mah]
synonym: "stimulation of transposon integration" NARROW [GOC:mah]
synonym: "up regulation of transposon integration" EXACT [GOC:mah]
synonym: "up-regulation of transposon integration" EXACT [GOC:mah]
synonym: "upregulation of transposon integration" EXACT [GOC:mah]
is_a: GO:0010530 ! positive regulation of transposition
is_a: GO:0051054 ! positive regulation of DNA metabolic process
is_a: GO:0070894 ! regulation of transposon integration
relationship: positively_regulates GO:0070893 ! transposon integration

[Term]
id: GO:0070897
name: transcriptional preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription." [GOC:jp]
synonym: "transcription PIC biosynthesis" EXACT [GOC:mah]
synonym: "transcription PIC formation" EXACT [GOC:mah]
synonym: "transcriptional preinitiation complex formation" EXACT [GOC:mah]
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0006352 ! transcription initiation

[Term]
id: GO:0070898
name: RNA polymerase III transcriptional preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from the RNA polymerase III promoter." [GOC:jp, PMID:11387215]
synonym: "RNA polymerase III transcription PIC biosynthesis" EXACT [GOC:mah]
synonym: "RNA polymerase III transcription PIC formation" EXACT [GOC:mah]
synonym: "RNA polymerase III transcriptional preinitiation complex formation" EXACT [GOC:mah]
is_a: GO:0070897 ! transcriptional preinitiation complex assembly
relationship: part_of GO:0006384 ! transcription initiation from RNA polymerase III promoter

[Term]
id: GO:0070899
name: mitochondrial tRNA wobble uridine modification
namespace: biological_process
def: "The process whereby a uridine in position 34 of a mitochondrial tRNA is post-transcriptionally modified." [GOC:mah, GOC:mcc]
is_a: GO:0002098 ! tRNA wobble uridine modification
is_a: GO:0070900 ! mitochondrial tRNA modification

[Term]
id: GO:0070900
name: mitochondrial tRNA modification
namespace: biological_process
def: "The covalent alteration of one or more nucleotides within a mitochondrial tRNA molecule to produce a mitochondrial tRNA molecule with a sequence that differs from that coded genetically." [GOC:mah, GOC:mcc]
is_a: GO:0006400 ! tRNA modification
is_a: GO:0070525 ! threonylcarbamoyladenosine metabolic process

[Term]
id: GO:0070901
name: mitochondrial tRNA methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc]
is_a: GO:0030488 ! tRNA methylation
is_a: GO:0070900 ! mitochondrial tRNA modification

[Term]
id: GO:0070902
name: mitochondrial tRNA pseudouridine synthesis
namespace: biological_process
def: "The intramolecular conversion of uridine to pseudouridine in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc]
is_a: GO:0031119 ! tRNA pseudouridine synthesis
is_a: GO:0070900 ! mitochondrial tRNA modification

[Term]
id: GO:0070903
name: mitochondrial tRNA thio-modification
namespace: biological_process
def: "The addition a sulfur atom to a nucleotide in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc]
is_a: GO:0034227 ! tRNA thio-modification
is_a: GO:0070900 ! mitochondrial tRNA modification

[Term]
id: GO:0070904
name: transepithelial L-ascorbic acid transport
namespace: biological_process
def: "The directed movement of L-ascorbic acid from one side of an epithelium to the other." [GOC:mah, GOC:yaf]
synonym: "transepithelial L-ascorbate transport" EXACT [GOC:mah]
synonym: "transepithelial vitamin C transport" EXACT [GOC:mah]
is_a: GO:0015882 ! L-ascorbic acid transport
is_a: GO:0070633 ! transepithelial transport

[Term]
id: GO:0070905
name: serine binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with 2-amino-3-hydroxypropanoic acid." [ChEBI:17822, GOC:rph]
synonym: "Ser binding" EXACT [GOC:mah]
is_a: GO:0016597 ! amino acid binding

[Term]
id: GO:0070906
name: aspartate:alanine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: aspartate(out) + alanine(in) = aspartate(in) + alanine(out)." [GOC:dh]
synonym: "aspartate-alanine antiporter activity" EXACT [GOC:mah]
synonym: "aspartate/alanine antiporter activity" EXACT [GOC:mah]
is_a: GO:0015300 ! solute:solute antiporter activity

[Term]
id: GO:0070907
name: histidine:histamine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: histidine(out) + histamine(in) = histidine(in) + histamine(out)." [GOC:dh]
synonym: "histidine-histamine antiporter activity" EXACT [GOC:mah]
synonym: "histidine/histamine antiporter activity" EXACT [GOC:mah]
is_a: GO:0015300 ! solute:solute antiporter activity

[Term]
id: GO:0070908
name: tyrosine:tyramine antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out)." [GOC:dh]
synonym: "tyrosine-tyramine antiporter activity" EXACT [GOC:mah]
synonym: "tyrosine/tyramine antiporter activity" EXACT [GOC:mah]
is_a: GO:0015300 ! solute:solute antiporter activity

[Term]
id: GO:0070909
name: glutamate:gamma-aminobutyric acid antiporter activity
namespace: molecular_function
def: "Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out)." [GOC:dh]
synonym: "glutamate-gamma-aminobutyric acid antiporter activity" EXACT [GOC:mah]
synonym: "glutamate/gamma-aminobutyric acid antiporter activity" EXACT [GOC:mah]
synonym: "glutamate: GABA antiporter activity" EXACT [GOC:dh]
is_a: GO:0015300 ! solute:solute antiporter activity

[Term]
id: GO:0070910
name: cell wall macromolecule catabolic process involved in cell wall disassembly
namespace: biological_process
def: "The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the cell wall." [GOC:mah]
is_a: GO:0016998 ! cell wall macromolecule catabolic process
relationship: part_of GO:0060871 ! cellular cell wall disassembly

[Term]
id: GO:0070911
name: global genome nucleotide-excision repair
namespace: biological_process
def: "The nucleotide-excision repair process by which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome." [PMID:10197977, PMID:18794354]
subset: gosubset_prok
synonym: "GG-NER" EXACT [PMID:10197977]
synonym: "GGR" EXACT [GOC:vw, PMID:18794354]
synonym: "global genome NER" EXACT [GOC:mah]
synonym: "global genomic nucleotide-excision repair" EXACT [GOC:mah, GOC:vw]
synonym: "global genomic repair" EXACT [GOC:vw, PMID:18794354]
is_a: GO:0006289 ! nucleotide-excision repair

[Term]
id: GO:0070912
name: Ddb1-Ckn1 complex
namespace: cellular_component
def: "A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Ckn1 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases." [PMID:18794354]
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0070913
name: Ddb1-Wdr21 complex
namespace: cellular_component
def: "A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Wdr21 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases." [PMID:18794354]
is_a: GO:0000109 ! nucleotide-excision repair complex

[Term]
id: GO:0070914
name: UV-damage excision repair
namespace: biological_process
def: "A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [GOC:mah, PMID:9619100]
synonym: "UV-damaged DNA endonuclease-dependent excision repair" EXACT [GOC:vw]
synonym: "UVDE-dependent excision repair" EXACT [GOC:vw, PMID:9619100]
synonym: "UVER" EXACT [GOC:vw, PMID:9619100]
is_a: GO:0006281 ! DNA repair

[Term]
id: GO:0070915
name: lysophosphatidic acid receptor activity
namespace: molecular_function
def: "Combining with lysophosphatidic acid to initiate a change in cell activity." [GOC:mah]
is_a: GO:0045125 ! bioactive lipid receptor activity

[Term]
id: GO:0070916
name: inositol phosphoceramide synthase complex
namespace: cellular_component
def: "A protein complex that possesses inositol phosphoceramide synthase activity and contains a catalytic subunit and a regulatory subunit (Aur1p and Kei1p, respectively, in Saccharomyces)." [GOC:mah, PMID:19726565]
synonym: "IPC synthase complex" EXACT [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044431 ! Golgi apparatus part

[Term]
id: GO:0070917
name: inositol phosphoceramide synthase regulator activity
namespace: molecular_function
def: "Modulates the activity of inositol phosphoceramide synthase." [GOC:mah]
comment: See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'.
synonym: "IPC synthase regulator activity" EXACT []
is_a: GO:0030234 ! enzyme regulator activity

[Term]
id: GO:0070918
name: production of small RNA involved in gene silencing by RNA
namespace: biological_process
def: "The process by which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease." [GOC:mah, PMID:19239886]
synonym: "gene silencing by RNA, production of guide RNA" EXACT [GOC:mah]
synonym: "gene silencing by RNA, production of small RNA" EXACT [GOC:mah]
is_a: GO:0031050 ! dsRNA fragmentation
relationship: part_of GO:0031047 ! gene silencing by RNA

[Term]
id: GO:0070919
name: production of siRNA involved in chromatin silencing by small RNA
namespace: biological_process
def: "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of chromatin silencing by small RNA." [GOC:mah, PMID:19239886]
synonym: "chromatin silencing by small RNA, production of guide RNAs" EXACT []
synonym: "chromatin silencing by small RNA, production of siRNA" EXACT [GOC:mah]
synonym: "production of guide RNAs involved in chromatin silencing by small RNA" EXACT [GOC:mah]
is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA
relationship: part_of GO:0031048 ! chromatin silencing by small RNA

[Term]
id: GO:0070920
name: regulation of production of small RNA involved in gene silencing by RNA
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the production of small RNA involved in gene silencing by RNA." [GOC:mah]
synonym: "regulation of gene silencing by RNA, production of guide RNA" EXACT [GOC:mah]
synonym: "regulation of gene silencing by RNA, production of small RNA" EXACT [GOC:mah]
is_a: GO:0010468 ! regulation of gene expression
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0051252 ! regulation of RNA metabolic process
is_a: GO:0060966 ! regulation of gene silencing by RNA
relationship: regulates GO:0070918 ! production of small RNA involved in gene silencing by RNA

[Term]
id: GO:0070921
name: regulation of production of siRNA involved in chromatin silencing by small RNA
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the production of siRNA, the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of chromatin silencing by small RNA." [GOC:mah]
synonym: "regulation of chromatin silencing by small RNA, production of siRNA" EXACT [GOC:mah]
is_a: GO:0010964 ! regulation of chromatin silencing by small RNA
is_a: GO:0070920 ! regulation of production of small RNA involved in gene silencing by RNA
relationship: regulates GO:0070919 ! production of siRNA involved in chromatin silencing by small RNA

[Term]
id: GO:0070922
name: small RNA loading onto RISC
namespace: biological_process
def: "The process by which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA." [GOC:mah, PMID:19239886]
synonym: "gene silencing by RNA, small RNA loading onto RISC" EXACT [GOC:mah]
synonym: "RISC assembly" RELATED [GOC:mah]
is_a: GO:0022618 ! ribonucleoprotein complex assembly
relationship: part_of GO:0031047 ! gene silencing by RNA

[Term]
id: GO:0070923
name: siRNA loading onto RISC involved in chromatin silencing by small RNA
namespace: biological_process
def: "The process by which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of chromatin silencing by small RNA." [GOC:mah, PMID:19239886]
synonym: "chromatin silencing by small RNA, siRNA loading onto RISC" EXACT [GOC:mah]
is_a: GO:0070922 ! small RNA loading onto RISC
relationship: part_of GO:0031048 ! chromatin silencing by small RNA

[Term]
id: GO:0070924
name: heterochromatin formation involved in chromatin silencing by small RNA
namespace: biological_process
def: "The process by which an siRNA-associated RNA-induced silencing complex (siRISC) associates with nascent transcripts and RNA polymerase to induce the formation of heterochromatin." [GOC:mah, PMID:19239886]
synonym: "chromatin silencing by small RNA, heterochromatin formation" EXACT [GOC:mah]
synonym: "small RNA-mediated heterochromatin biosynthesis" EXACT [GOC:mah]
synonym: "small RNA-mediated heterochromatin formation" EXACT [GOC:mah]
is_a: GO:0070869 ! heterochromatin formation involved in chromatin silencing
relationship: part_of GO:0031048 ! chromatin silencing by small RNA

[Term]
id: GO:0070925
name: organelle assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah]
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0006996 ! organelle organization

[Term]
id: GO:0070926
name: regulation of ATP:ADP antiporter activity
namespace: biological_process
def: "Any process that modulates the activity of an ATP:ADP antiporter." [GOC:BHF, GOC:mah]
is_a: GO:0022898 ! regulation of transmembrane transporter activity

[Term]
id: GO:0070927
name: negative regulation of ATP:ADP antiporter activity
namespace: biological_process
def: "Any process that stops or reduces the activity of an ATP:ADP antiporter." [GOC:BHF, GOC:mah]
synonym: "down regulation of ATP:ADP antiporter activity" EXACT [GOC:mah]
synonym: "down-regulation of ATP:ADP antiporter activity" EXACT [GOC:mah]
synonym: "downregulation of ATP:ADP antiporter activity" EXACT [GOC:mah]
synonym: "inhibition of ATP:ADP antiporter activity" NARROW [GOC:mah]
is_a: GO:0032410 ! negative regulation of transporter activity
is_a: GO:0070926 ! regulation of ATP:ADP antiporter activity

[Term]
id: GO:0070928
name: regulation of mRNA stability, ncRNA-mediated
namespace: biological_process
def: "Any process, mediated by small non-coding RNAs, that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jh2]
synonym: "ncRNA-mediated regulation of mRNA stability" EXACT [GOC:mah]
synonym: "regulation of mRNA stability, non-coding RNA-mediated" EXACT [GOC:mah]
is_a: GO:0043488 ! regulation of mRNA stability

[Term]
id: GO:0070929
name: trans-translation
namespace: biological_process
def: "A translational elongation process in which transfer of a translating ribosome from one mRNA to another RNA template takes place. Trans-translation occurs during tmRNA release of stalled ribosomes." [GOC:jh2, GOC:mah]
is_a: GO:0006414 ! translational elongation

[Term]
id: GO:0070930
name: co-translational protein tagging
namespace: biological_process
def: "A protein modification process in which a polypeptide is added to a nascent polypeptide cotranslationally by trans-translation." [GOC:jh2, GOC:mah]
comment: Note that this term is not a child of 'co-translational protein modification process ; GO:0043686' because co-translational protein modification implies modification of a previously incorporated amino acid in a nascent chain, rather than addition of new sequence to the C-terminus.
synonym: "cotranslational protein tagging" EXACT [GOC:mah]
synonym: "protein modification by trans-translation" EXACT [GOC:mah]
is_a: GO:0006464 ! protein modification process

[Term]
id: GO:0070931
name: Golgi-associated vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of a Golgi-associated vesicle." [GOC:mah]
is_a: GO:0044431 ! Golgi apparatus part
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0005798 ! Golgi-associated vesicle

[Term]
id: GO:0070932
name: histone H3 deacetylation
namespace: biological_process
def: "The modification of histone H3 by the removal of one or more acetyl groups." [GOC:BHF, GOC:rl]
is_a: GO:0016575 ! histone deacetylation

[Term]
id: GO:0070933
name: histone H4 deacetylation
namespace: biological_process
def: "The modification of histone H4 by the removal of one or more acetyl groups." [GOC:BHF, GOC:rl]
is_a: GO:0016575 ! histone deacetylation

[Term]
id: GO:0070934
name: CRD-mediated mRNA stabilization
namespace: biological_process
def: "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303]
synonym: "coding region determinant-mediated mRNA stabilization" EXACT [GOC:mah]
is_a: GO:0048255 ! mRNA stabilization

[Term]
id: GO:0070935
name: 3'-UTR-mediated mRNA stabilization
namespace: biological_process
def: "An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:mah, PMID:19029303]
synonym: "3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:mah]
is_a: GO:0048255 ! mRNA stabilization

[Term]
id: GO:0070936
name: protein K48-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404]
is_a: GO:0016567 ! protein ubiquitination

[Term]
id: GO:0070937
name: CRD-mediated mRNA stability complex
namespace: cellular_component
def: "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, IGF2BP1 and at least four additional proteins: HNRNPU, SYNCRIP, YBX1, and DHX9." [GOC:mah, PMID:19029303]
comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0070938
name: contractile ring
namespace: cellular_component
def: "A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles." [GOC:mah, ISBN:0123645859, ISBN:0792354923, PMID:10791428, PMID:17913889]
synonym: "constriction ring" RELATED [GOC:mah]
synonym: "cytokinetic ring" RELATED [GOC:mah]
is_a: GO:0044464 ! cell part

[Term]
id: GO:0070939
name: Dsl1p complex
namespace: cellular_component
def: "A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p." [GOC:jh, GOC:mah, PMID:19151722]
comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0070940
name: dephosphorylation of RNA polymerase II C-terminal domain
namespace: biological_process
def: "The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form." [GOC:krc, GOC:mah, PMID:17079683]
synonym: "CTD domain dephosphorylation of RNA polymerase II" EXACT [GOC:mah]
synonym: "generation of hypophosphorylated CTD of RNA polymerase II" EXACT [GOC:krc]
synonym: "generation of II(A) form of RNA polymerase II" EXACT [GOC:krc]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
is_a: GO:0006470 ! protein amino acid dephosphorylation

[Term]
id: GO:0070941
name: eisosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form an eisosome, a large immobile protein complex that forms at the plasma membrane and marks endocytic sites." [GOC:jp, PMID:19564405]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0070942
name: neutrophil mediated cytotoxicity
namespace: biological_process
def: "The directed killing of a target cell by a neutrophil." [GOC:add, ISBN:0781765196]
synonym: "neutrophil mediated cell killing" EXACT [GOC:add]
is_a: GO:0001909 ! leukocyte mediated cytotoxicity
relationship: part_of GO:0002446 ! neutrophil mediated immunity

[Term]
id: GO:0070943
name: neutrophil mediated killing of symbiont cell
namespace: biological_process
def: "The directed killing of a symbiont target cell by a neutrophil." [GOC:add, ISBN:0781765196]
is_a: GO:0051873 ! killing by host of symbiont cells
is_a: GO:0070942 ! neutrophil mediated cytotoxicity

[Term]
id: GO:0070944
name: neutrophil mediated killing of bacterium
namespace: biological_process
def: "The directed killing of a bacterium by a neutrophil." [GOC:add, ISBN:0781765196]
is_a: GO:0070943 ! neutrophil mediated killing of symbiont cell
relationship: part_of GO:0042742 ! defense response to bacterium

[Term]
id: GO:0070945
name: neutrophil mediated killing of gram-negative bacterium
namespace: biological_process
def: "The directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, ISBN:0781765196]
is_a: GO:0070944 ! neutrophil mediated killing of bacterium
relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium

[Term]
id: GO:0070946
name: neutrophil mediated killing of gram-positive bacterium
namespace: biological_process
def: "The directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, ISBN:0781765196]
is_a: GO:0070944 ! neutrophil mediated killing of bacterium
relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium

[Term]
id: GO:0070947
name: neutrophil mediated killing of fungus
namespace: biological_process
def: "The directed killing of a fungal cell by a neutrophil." [GOC:add, ISBN:0781765196]
is_a: GO:0070943 ! neutrophil mediated killing of symbiont cell
relationship: part_of GO:0050832 ! defense response to fungus

[Term]
id: GO:0070948
name: regulation of neutrophil mediated cytotoxicity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "regulation of neutrophil mediated cell killing" EXACT [GOC:add]
is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity
is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity
relationship: regulates GO:0070942 ! neutrophil mediated cytotoxicity

[Term]
id: GO:0070949
name: regulation of neutrophil mediated killing of symbiont cell
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a symbiont cell, the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah]
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
is_a: GO:0051709 ! regulation of killing of cells of another organism
is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity
relationship: regulates GO:0070943 ! neutrophil mediated killing of symbiont cell

[Term]
id: GO:0070950
name: regulation of neutrophil mediated killing of bacterium
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a bacterium, the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell
relationship: regulates GO:0070944 ! neutrophil mediated killing of bacterium

[Term]
id: GO:0070951
name: regulation of neutrophil mediated killing of gram-negative bacterium
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-negative bacterium, the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah]
is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium
relationship: regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium

[Term]
id: GO:0070952
name: regulation of neutrophil mediated killing of gram-positive bacterium
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-positive bacterium, the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah]
is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium
relationship: regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium

[Term]
id: GO:0070953
name: regulation of neutrophil mediated killing of fungus
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a fungal cell, the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah]
is_a: GO:0002831 ! regulation of response to biotic stimulus
is_a: GO:0031347 ! regulation of defense response
is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell
relationship: regulates GO:0070947 ! neutrophil mediated killing of fungus

[Term]
id: GO:0070954
name: negative regulation of neutrophil mediated cytotoxicity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated cytotoxicity" NARROW [GOC:mah]
synonym: "negative regulation of neutrophil mediated cell killing" EXACT [GOC:add]
is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity
is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity
relationship: negatively_regulates GO:0070942 ! neutrophil mediated cytotoxicity

[Term]
id: GO:0070955
name: negative regulation of neutrophil mediated killing of symbiont cell
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah]
is_a: GO:0051711 ! negative regulation of killing of cells of another organism
is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell
is_a: GO:0070954 ! negative regulation of neutrophil mediated cytotoxicity
relationship: negatively_regulates GO:0070943 ! neutrophil mediated killing of symbiont cell

[Term]
id: GO:0070956
name: negative regulation of neutrophil mediated killing of bacterium
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated killing of bacterium" NARROW [GOC:mah]
is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium
is_a: GO:0070955 ! negative regulation of neutrophil mediated killing of symbiont cell
relationship: negatively_regulates GO:0070944 ! neutrophil mediated killing of bacterium

[Term]
id: GO:0070957
name: negative regulation of neutrophil mediated killing of gram-negative bacterium
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah]
is_a: GO:0070951 ! regulation of neutrophil mediated killing of gram-negative bacterium
is_a: GO:0070956 ! negative regulation of neutrophil mediated killing of bacterium
relationship: negatively_regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium

[Term]
id: GO:0070958
name: negative regulation of neutrophil mediated killing of gram-positive bacterium
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah]
is_a: GO:0070952 ! regulation of neutrophil mediated killing of gram-positive bacterium
is_a: GO:0070956 ! negative regulation of neutrophil mediated killing of bacterium
relationship: negatively_regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium

[Term]
id: GO:0070959
name: negative regulation of neutrophil mediated killing of fungus
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "down regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
synonym: "down-regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
synonym: "downregulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
synonym: "inhibition of neutrophil mediated killing of fungus" NARROW [GOC:mah]
is_a: GO:0070953 ! regulation of neutrophil mediated killing of fungus
is_a: GO:0070955 ! negative regulation of neutrophil mediated killing of symbiont cell
relationship: negatively_regulates GO:0070947 ! neutrophil mediated killing of fungus

[Term]
id: GO:0070960
name: positive regulation of neutrophil mediated cytotoxicity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated cytotoxicity" NARROW [GOC:mah]
synonym: "positive regulation of neutrophil mediated cell killing" EXACT [GOC:add]
synonym: "stimulation of neutrophil mediated cytotoxicity" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah]
is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity
is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity
relationship: positively_regulates GO:0070942 ! neutrophil mediated cytotoxicity

[Term]
id: GO:0070961
name: positive regulation of neutrophil mediated killing of symbiont cell
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah]
synonym: "stimulation of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah]
is_a: GO:0051712 ! positive regulation of killing of cells of another organism
is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell
is_a: GO:0070960 ! positive regulation of neutrophil mediated cytotoxicity
relationship: positively_regulates GO:0070943 ! neutrophil mediated killing of symbiont cell

[Term]
id: GO:0070962
name: positive regulation of neutrophil mediated killing of bacterium
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated killing of bacterium" NARROW [GOC:mah]
synonym: "stimulation of neutrophil mediated killing of bacterium" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah]
is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium
is_a: GO:0070961 ! positive regulation of neutrophil mediated killing of symbiont cell
relationship: positively_regulates GO:0070944 ! neutrophil mediated killing of bacterium

[Term]
id: GO:0070963
name: positive regulation of neutrophil mediated killing of gram-negative bacterium
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah]
synonym: "stimulation of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah]
is_a: GO:0070951 ! regulation of neutrophil mediated killing of gram-negative bacterium
is_a: GO:0070962 ! positive regulation of neutrophil mediated killing of bacterium
relationship: positively_regulates GO:0070945 ! neutrophil mediated killing of gram-negative bacterium

[Term]
id: GO:0070964
name: positive regulation of neutrophil mediated killing of gram-positive bacterium
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah]
synonym: "stimulation of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah]
is_a: GO:0070952 ! regulation of neutrophil mediated killing of gram-positive bacterium
is_a: GO:0070962 ! positive regulation of neutrophil mediated killing of bacterium
relationship: positively_regulates GO:0070946 ! neutrophil mediated killing of gram-positive bacterium

[Term]
id: GO:0070965
name: positive regulation of neutrophil mediated killing of fungus
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah]
synonym: "activation of neutrophil mediated killing of fungus" NARROW [GOC:mah]
synonym: "stimulation of neutrophil mediated killing of fungus" NARROW [GOC:mah]
synonym: "up regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
synonym: "up-regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
synonym: "upregulation of neutrophil mediated killing of fungus" EXACT [GOC:mah]
is_a: GO:0070953 ! regulation of neutrophil mediated killing of fungus
is_a: GO:0070961 ! positive regulation of neutrophil mediated killing of symbiont cell
relationship: positively_regulates GO:0070947 ! neutrophil mediated killing of fungus

[Term]
id: GO:0070966
name: nuclear-transcribed mRNA catabolic process, no-go decay
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation." [GOC:jp, PMID:16554824]
synonym: "no-go decay" EXACT [GOC:jp]
synonym: "no-go mRNA decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA breakdown, no-go decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA catabolism, no-go decay" EXACT [GOC:jp]
synonym: "nuclear-transcribed mRNA degradation, no-go decay" EXACT [GOC:jp]
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process

[Term]
id: GO:0070967
name: coenzyme F420 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with F420, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [ChEBI:16848, GOC:dh]
is_a: GO:0050662 ! coenzyme binding

[Term]
id: GO:0070968
name: pyrroloquinoline quinone binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with pyrroloquinoline quinone, PQQ, the coenzyme or the prosthetic group of certain alcohol dehydrogenases and glucose dehydrogenases." [ChEBI:18315, GOC:dh]
synonym: "PQQ binding" EXACT [GOC:dh]
is_a: GO:0048038 ! quinone binding

[Term]
id: GO:0070969
name: ULK1-ATG13-FIP200 complex
namespace: cellular_component
def: "A protein complex that is essential for mammalian autophagy, and consists of at least 3 proteins: ULK1, ATG13 and RB1CC1(FIP200). This complex is the mammalian counterpart of Atg1-Atg13-Atg17 in yeast." [PMID:19211835, PMID:19258318, PMID:19597335]
synonym: "ULK1-ATG13-RB1CC1 complex" EXACT [GOC:curators]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0070970
name: interleukin-2 secretion
namespace: biological_process
def: "The regulated release of interleukin-2 from a cell or group of cells." [GOC:mah, PMID:16930574]
synonym: "IL-2 secretion" EXACT [GOC:mah]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032623 ! interleukin-2 production

[Term]
id: GO:0070971
name: endoplasmic reticulum exit site
namespace: cellular_component
def: "An endoplasmic reticulum part at which COPII-coated vesicles are produced." [PMID:15623529, PMID:16957052]
synonym: "ER exit site" EXACT [GOC:mah]
synonym: "transitional ER" EXACT [PMID:15623529]
is_a: GO:0044432 ! endoplasmic reticulum part

[Term]
id: GO:0070972
name: protein localization in endoplasmic reticulum
namespace: biological_process
def: "A process by which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah]
synonym: "protein localization in ER" EXACT [GOC:mah]
synonym: "protein localization to endoplasmic reticulum" EXACT [GOC:mah]
is_a: GO:0033365 ! protein localization in organelle

[Term]
id: GO:0070973
name: protein localization to endoplasmic reticulum exit site
namespace: biological_process
def: "A process by which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site." [GOC:mah]
synonym: "protein localization to ER exit site" EXACT [GOC:mah]
is_a: GO:0070972 ! protein localization in endoplasmic reticulum

[Term]
id: GO:0070974
name: POU domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors." [GOC:mah, GOC:yaf, InterPro:IPR000327]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070975
name: FHA domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich." [GOC:mah, InterPro:IPR000253]
synonym: "Forkhead-associated domain binding" EXACT [InterPro:IPR000253]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070976
name: TIR domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157]
synonym: "Toll-Interleukin receptor domain binding" EXACT [InterPro:IPR000157]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070977
name: bone maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state." [GOC:dph, GOC:mah]
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0060348 ! bone development

[Term]
id: GO:0070978
name: voltage-gated calcium channel complex assembly
namespace: biological_process
def: "Cellular protein complex assembly that results in the formation of a voltage-gated calcium channel complex." [GOC:mh]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0070979
name: protein K11-linked ubiquitination
namespace: biological_process
def: "A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, PMID:18485873]
is_a: GO:0016567 ! protein ubiquitination

[Term]
id: GO:0070980
name: biphenyl catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs)." [ChEBI:17097, PMID:16310831, PMID:16339959, UniPathway:UPA00155]
synonym: "biphenyl breakdown" EXACT [GOC:mah]
synonym: "biphenyl catabolism" EXACT [GOC:mah]
synonym: "biphenyl degradation" EXACT [GOC:mah]
is_a: GO:0018879 ! biphenyl metabolic process
is_a: GO:0042178 ! xenobiotic catabolic process

[Term]
id: GO:0070981
name: L-asparagine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [ChEBI:17196, GOC:mah]
subset: gosubset_prok
synonym: "L-asparagine anabolism" EXACT [GOC:mah]
synonym: "L-asparagine biosynthesis" EXACT [GOC:mah]
synonym: "L-asparagine formation" EXACT [GOC:mah]
synonym: "L-asparagine synthesis" EXACT [GOC:mah]
is_a: GO:0006529 ! asparagine biosynthetic process
is_a: GO:0070982 ! L-asparagine metabolic process

[Term]
id: GO:0070982
name: L-asparagine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving L-asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [ChEBI:17196, GOC:mah]
subset: gosubset_prok
synonym: "L-asparagine metabolism" EXACT [GOC:mah]
is_a: GO:0006528 ! asparagine metabolic process

[Term]
id: GO:0070983
name: dendrite guidance
namespace: biological_process
def: "The process by which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878]
synonym: "dendritic guidance" EXACT [GOC:sart]
is_a: GO:0006928 ! cellular component movement
relationship: part_of GO:0048813 ! dendrite morphogenesis

[Term]
id: GO:0070984
name: SET domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation." [GOC:sart, Pfam:PF00856, PMID:12575990]
synonym: "SET binding" EXACT [GOC:sart]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0070985
name: TFIIK complex
namespace: cellular_component
def: "A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces, TFIIK contains Ccl1p, Tfb3p and Kin2p." [GOC:mah, PMID:19818408]
is_a: GO:0005667 ! transcription factor complex
relationship: part_of GO:0005675 ! holo TFIIH complex

[Term]
id: GO:0070986
name: left/right axis specification
namespace: biological_process
def: "The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes)." [GOC:dph, GOC:gvg, GOC:mah]
synonym: "left-right axis specification" EXACT [GOC:mah]
synonym: "left/right axis determination" RELATED [GOC:dph]
is_a: GO:0009798 ! axis specification
relationship: part_of GO:0060972 ! left/right pattern formation

[Term]
id: GO:0070987
name: error-free translesion synthesis
namespace: biological_process
def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level." [GOC:elh]
comment: Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication.
subset: gosubset_prok
is_a: GO:0019985 ! translesion synthesis

[Term]
id: GO:0070988
name: demethylation
namespace: biological_process
def: "The process of removing one or more methyl groups from a molecule." [GOC:BHF, GOC:rl]
is_a: GO:0006730 ! one-carbon metabolic process

[Term]
id: GO:0070989
name: oxidative demethylation
namespace: biological_process
def: "The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate." [GOC:BHF, GOC:mah, GOC:rl]
is_a: GO:0055114 ! oxidation reduction
is_a: GO:0070988 ! demethylation

[Term]
id: GO:0070990
name: snRNP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with any part of a small nuclear ribonucleoprotein particle." [GOC:BHF, GOC:mah, GOC:rl]
is_a: GO:0043021 ! ribonucleoprotein binding

[Term]
id: GO:0070991
name: medium-chain-acyl-CoA dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue." [GOC:BHF, GOC:mah]
synonym: "MCAD activity" EXACT [GOC:mah]
xref: EC:1.3.99.-
is_a: GO:0003995 ! acyl-CoA dehydrogenase activity

[Term]
id: GO:0070992
name: translation initiation complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains a ribosome, mRNA, and initiator tRNA; the functional ribosome is at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd, GOC:mah]
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0070993
name: translation preinitiation complex
namespace: cellular_component
def: "A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA." [GOC:hjd, GOC:mah]
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0070994
name: detection of oxidative stress
namespace: biological_process
def: "The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal." [GOC:mah]
is_a: GO:0006979 ! response to oxidative stress

[Term]
id: GO:0070995
name: NADPH oxidation
namespace: biological_process
def: "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP." [GOC:BHF, GOC:mah]
synonym: "NADP (reduced) dehydrogenation" EXACT [GOC:mah]
synonym: "NADP (reduced) oxidation" EXACT [GOC:mah]
synonym: "NADPH dehydrogenation" EXACT [GOC:mah]
synonym: "reduced NADP dehydrogenation" EXACT [GOC:mah]
synonym: "reduced NADP oxidation" EXACT [GOC:mah]
synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenation" EXACT [GOC:mah]
synonym: "reduced nicotinamide adenine dinucleotide phosphate oxidation" EXACT [GOC:mah]
is_a: GO:0006739 ! NADP metabolic process

[Term]
id: GO:0070996
name: type 1 melanocortin receptor binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a type 1 melanocortin receptor." [GOC:BHF, GOC:mah]
synonym: "type 1 melanocortin receptor ligand" NARROW [GOC:mah]
is_a: GO:0031779 ! melanocortin receptor binding

[Term]
id: GO:0070997
name: neuron death
namespace: biological_process
def: "The process of cell death in a neuron." [GOC:BHF, GOC:mah]
synonym: "neuron cell death" EXACT [GOC:mah, GOC:rl]
synonym: "neuronal cell death" EXACT [GOC:mah]
is_a: GO:0008219 ! cell death

[Term]
id: GO:0070998
name: sensory perception of gravity
namespace: biological_process
def: "The series of events required for an organism to receive a gravitational stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:mah]
is_a: GO:0007600 ! sensory perception

[Term]
id: GO:0070999
name: detection of mechanical stimulus involved in sensory perception of gravity
namespace: biological_process
def: "The series of events involved in the perception of gravity in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:mah]
is_a: GO:0009590 ! detection of gravity
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: part_of GO:0070998 ! sensory perception of gravity

[Term]
id: GO:0071000
name: response to magnetism
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus." [GOC:sl]
synonym: "response to magnetic stimulus" EXACT [GOC:mah]
is_a: GO:0009628 ! response to abiotic stimulus

[Term]
id: GO:0071001
name: U4/U6 snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains base-paired U4 and U6 small nuclear RNAs." [GOC:mah, PMID:14685174]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0071002
name: U4atac/U6atac snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains base-paired U4atac and U6atac small nuclear RNAs." [GOC:mah, PMID:14685174]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0071003
name: penta-snRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex formed by the association of the U1, U2, U4/U6 and U5 small nuclear ribonucleoproteins." [GOC:mah, PMID:11804584, PMID:12724403]
synonym: "penta-RNP complex" EXACT [GOC:rb]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0071004
name: U2-type prespliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]
synonym: "GT-AG prespliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "major prespliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "yeast U2-type spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071010 ! prespliceosome

[Term]
id: GO:0071005
name: U2-type precatalytic spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
synonym: "GT-AG precatalytic spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "major precatalytic spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U2-type spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast U12-type spliceosomal complex A2-1" RELATED [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071011 ! precatalytic spliceosome

[Term]
id: GO:0071006
name: U2-type catalytic step 1 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
synonym: "GT-AG catalytic step 1 spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "major catalytic step 1 spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U2-type spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "U2-type activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast U2-type spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071012 ! catalytic step 1 spliceosome

[Term]
id: GO:0071007
name: U2-type catalytic step 2 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
synonym: "GT-AG catalytic step 2 spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "major catalytic step 2 spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U2-type spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast U2-type spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071013 ! catalytic step 2 spliceosome

[Term]
id: GO:0071008
name: U2-type post-mRNA release spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "GT-AG post-mRNA release spliceosomal complex" NARROW [GOC:krc, GOC:mah]
synonym: "major post-mRNA release spliceosomal complex" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071014 ! post-mRNA release spliceosomal complex

[Term]
id: GO:0071009
name: U4atac/U6atac x U5 tri-snRNP complex
namespace: cellular_component
def: "A ribonucleoprotein complex formed by the association of the U4atac/U6atac and U5 small nuclear ribonucleoproteins." [GOC:mah, PMID:16201866]
synonym: "U4atac/U6atac . U5 snRNP complex" EXACT []
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0071010
name: prespliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]
synonym: "mammalian spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "yeast spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0071011
name: precatalytic spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
synonym: "mammalian spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast spliceosomal complex A2-1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0071012
name: catalytic step 1 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]
synonym: "activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393]
synonym: "mammalian spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0071013
name: catalytic step 2 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]
synonym: "mammalian spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0071014
name: post-mRNA release spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0071015
name: U12-type prespliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the cooperative binding of the heterodimeric U11/U12 snRNP to the 5' splice site and the branch point sequence. The U12-type prespliceosome includes many proteins in addition to those found in the U11/U12 heterodimeric snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:10197985, PMID:16201866]
synonym: "AT-AC prespliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "minor prespliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "yeast U12-type spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0071010 ! prespliceosome

[Term]
id: GO:0071016
name: U12-type precatalytic spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the recruitment of the preassembled U4atac/U6atac.U5 tri-snRNP to the U12-type prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U11, U12 and U4atac/U6atac.U5 snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:16201866]
synonym: "AT-AC precatalytic spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U12-type spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "minor precatalytic spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "yeast U12-type spliceosomal complex A2-1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0071011 ! precatalytic spliceosome

[Term]
id: GO:0071017
name: U12-type catalytic step 1 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that is formed by the displacement of the U11 and U4atac snRNPs from the precatalytic spliceosome; the U12, U5 and U6atac snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U12, and U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866]
synonym: "AT-AC catalytic step 1 spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U12-type spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "minor catalytic step 1 spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "U12-type activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast U12-type spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0071012 ! catalytic step 1 spliceosome

[Term]
id: GO:0071018
name: U12-type catalytic step 2 spliceosome
namespace: cellular_component
def: "A spliceosomal complex that contains the U12, U5 and U6atac snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U12, U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866]
synonym: "AT-AC catalytic step 2 spliceosome" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890]
synonym: "mammalian U12-type spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "minor catalytic step 2 spliceosome" EXACT [GOC:krc, GOC:mah]
synonym: "yeast U12-type spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0071013 ! catalytic step 2 spliceosome

[Term]
id: GO:0071019
name: U12-type post-mRNA release spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U12, U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866]
synonym: "AT-AC post-mRNA release spliceosomal complex" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "minor post-mRNA release spliceosomal complex" EXACT [GOC:krc, GOC:mah]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0005691 ! U6atac snRNP
is_a: GO:0005693 ! U12 snRNP
is_a: GO:0071014 ! post-mRNA release spliceosomal complex

[Term]
id: GO:0071020
name: post-spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "mammalian spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0071021
name: U2-type post-spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "GT-AG post-spliceosomal complex" NARROW [GOC:krc, GOC:mah]
synonym: "major post-spliceosomal complex" EXACT [GOC:krc, GOC:mah]
synonym: "mammalian U2-type spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "yeast U2-type spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005684 ! U2-type spliceosomal complex
is_a: GO:0071020 ! post-spliceosomal complex

[Term]
id: GO:0071022
name: U12-type post-spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "AT-AC post-spliceosomal complex" NARROW [GOC:krc, GOC:mah]
synonym: "mammalian U12-type spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
synonym: "minor post-spliceosomal complex" EXACT [GOC:krc, GOC:mah]
synonym: "yeast U12-type spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393]
is_a: GO:0005689 ! U12-type spliceosomal complex
is_a: GO:0071020 ! post-spliceosomal complex

[Term]
id: GO:0071023
name: trans spliceosomal complex
namespace: cellular_component
def: "A spliceosomal complex that forms during the addition of a specific spliced leader (SL) sequence to the 5'-end of a messenger RNA primary transcript, a process which occurs in a number of eukaryotic organisms, including trypanosomatid protozoans, euglenoids, nematodes, trematodes, and chordates." [GOC:krc, ISBN:0879697393]
is_a: GO:0005681 ! spliceosomal complex

[Term]
id: GO:0071024
name: SL snRNP
namespace: cellular_component
def: "A ribonucleoprotein complex that contains spliced leader (SL) RNA." [GOC:krc, ISBN:0879697393]
is_a: GO:0030532 ! small nuclear ribonucleoprotein complex

[Term]
id: GO:0071025
name: RNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading defective or aberrant RNAs." [GOC:df, GOC:krc, PMID:18644474]
synonym: "aberrant RNA catabolic process" EXACT [GOC:df, GOC:krc]
synonym: "RNA quality control" EXACT [GOC:df, GOC:krc]
is_a: GO:0006401 ! RNA catabolic process

[Term]
id: GO:0071026
name: cytoplasmic RNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading defective or aberrant RNAs within the cytoplasm." [GOC:df, GOC:krc, PMID:18644474]
synonym: "cytoplasmic aberrant RNA catabolic process" EXACT [GOC:df, GOC:krc]
synonym: "cytoplasmic RNA quality control" EXACT [GOC:df, GOC:krc]
is_a: GO:0071025 ! RNA surveillance

[Term]
id: GO:0071027
name: nuclear RNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading defective or aberrant RNAs within the nucleus." [GOC:df, GOC:krc, PMID:18644474]
synonym: "nuclear aberrant RNA catabolic process" EXACT [GOC:df, GOC:krc]
synonym: "nuclear RNA quality control" EXACT [GOC:df, GOC:krc]
is_a: GO:0071025 ! RNA surveillance

[Term]
id: GO:0071028
name: nuclear mRNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading defective or aberrant mRNAs within the nucleus." [GOC:df, GOC:krc, PMID:18644474]
synonym: "nuclear aberrant mRNA catabolic process" EXACT [GOC:df, GOC:krc]
synonym: "nuclear mRNA quality control" EXACT [GOC:df, GOC:krc]
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process
is_a: GO:0071027 ! nuclear RNA surveillance

[Term]
id: GO:0071029
name: nuclear ncRNA surveillance
namespace: biological_process
def: "The set of processes involved in identifying and degrading defective or aberrant ncRNAs within the nucleus." [GOC:df, GOC:krc, PMID:18644474]
synonym: "nuclear aberrant ncRNA catabolic process" EXACT [GOC:df, GOC:krc]
synonym: "nuclear ncRNA quality control" EXACT [GOC:df, GOC:krc]
is_a: GO:0034661 ! ncRNA catabolic process
is_a: GO:0071027 ! nuclear RNA surveillance

[Term]
id: GO:0071030
name: nuclear mRNA surveillance of spliceosomal pre-mRNA splicing
namespace: biological_process
def: "The set of processes involved in identifying and degrading incorrectly spliced pre-mRNAs within the nucleus." [GOC:df, GOC:krc, PMID:18644474]
synonym: "nuclear mRNA quality control of incorrectly spliced pre-mRNA" EXACT [GOC:df, GOC:krc]
synonym: "nuclear RNA catabolic process of incorrectly spliced pre-mRNA" EXACT [GOC:df, GOC:krc]
is_a: GO:0071028 ! nuclear mRNA surveillance

[Term]
id: GO:0071031
name: nuclear mRNA surveillance of mRNA 3'-end processing
namespace: biological_process
def: "The set of processes involved in identifying and degrading mRNAs with incorrectly formed 3'-ends within the nucleus." [GOC:df, GOC:krc, PMID:18644474]
synonym: "nuclear mRNA catabolic process of mRNA with aberrant 3'-ends" EXACT [GOC:df, GOC:krc]
synonym: "nuclear mRNA quality control of mRNAs with aberrant 3'-ends" EXACT [GOC:df, GOC:krc]
is_a: GO:0071028 ! nuclear mRNA surveillance

[Term]
id: GO:0071032
name: nuclear mRNA surveillance of mRNP export
namespace: biological_process
def: "The set of processes involved in identifying and degrading incorrectly formed or aberrant nuclear mRNPs docked at the nuclear pore complex prior to export to the cytoplasm." [GOC:df, GOC:krc, PMID:18644474]
synonym: "nuclear mRNA catabolic process of mRNAs in aberrant mRNPs" EXACT [GOC:df, GOC:krc]
synonym: "nuclear mRNA quality control of mRNAs in aberrant mRNPs" EXACT [GOC:df, GOC:krc]
is_a: GO:0071028 ! nuclear mRNA surveillance

[Term]
id: GO:0071033
name: nuclear retention of pre-mRNA at the site of transcription
namespace: biological_process
def: "The process involved in retention of aberrant or improperly formed mRNAs, e.g. those that are incorrectly or incompletely spliced or that have incorrectly formed 3'-ends, within the nucleus at the site of transcription." [GOC:df, GOC:krc, PMID:11586364, PMID:12417728, PMID:14718167, PMID:18644474]
is_a: GO:0008298 ! intracellular mRNA localization
relationship: part_of GO:0071028 ! nuclear mRNA surveillance

[Term]
id: GO:0071034
name: CUT catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of cryptic unstable transcripts (CUTs)." [GOC:df, GOC:krc]
synonym: "cryptic unstable transcript catabolic process" EXACT [GOC:df, GOC:krc]
is_a: GO:0034661 ! ncRNA catabolic process
is_a: GO:0071043 ! CUT metabolic process

[Term]
id: GO:0071035
name: nuclear polyadenylation-dependent rRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA." [GOC:df, GOC:krc, PMID:15173578, PMID:15572680, PMID:15935758, PMID:17652137, PMID:18591258]
is_a: GO:0016075 ! rRNA catabolic process
is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process

[Term]
id: GO:0071036
name: nuclear polyadenylation-dependent snoRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA." [GOC:df, GOC:krc, PMID:15935758]
is_a: GO:0016077 ! snoRNA catabolic process
is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process

[Term]
id: GO:0071037
name: nuclear polyadenylation-dependent snRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA." [GOC:df, GOC:krc]
is_a: GO:0016076 ! snRNA catabolic process
is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process

[Term]
id: GO:0071038
name: nuclear polyadenylation-dependent tRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an aberrant or incorrectly modified transfer RNA (tRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target tRNA." [GOC:df, GOC:krc]
is_a: GO:0016078 ! tRNA catabolic process
is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process

[Term]
id: GO:0071039
name: nuclear polyadenylation-dependent CUT catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT." [GOC:df, GOC:krc, PMID:15935759, PMID:16973436, PMID:16973437, PMID:18007593, PMID:18591258]
is_a: GO:0071034 ! CUT catabolic process
is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process

[Term]
id: GO:0071040
name: nuclear polyadenylation-dependent antisense transcript catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an antisense transcript, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target antisense transcript." [GOC:df, GOC:krc, PMID:18022365]
is_a: GO:0071041 ! antisense RNA transcript catabolic process
is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process

[Term]
id: GO:0071041
name: antisense RNA transcript catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of antisense transcripts, i.e. transcripts that were produced from the antisense strand of a gene that produces a gene product and which often have a regulatory effect on the transcription of that gene product." [GOC:df, GOC:krc]
is_a: GO:0034661 ! ncRNA catabolic process
is_a: GO:0042868 ! antisense RNA metabolic process

[Term]
id: GO:0071042
name: nuclear polyadenylation-dependent mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:df, GOC:krc, PMID:15145828, PMID:15828860, PMID:16431988, PMID:17643380, PMID:18000032, PMID:18644474]
is_a: GO:0071047 ! polyadenylation-dependent mRNA catabolic process

[Term]
id: GO:0071043
name: CUT metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving cryptic unstable transcripts (CUTs), which are transcribed from intergenic regions. Many intergenic regions are heavily transcribed, but the transcripts are rarely detected due to rapid degradation by the nuclear exosome." [GOC:df, GOC:krc, PMID:15935759, PMID:16973436]
is_a: GO:0034660 ! ncRNA metabolic process

[Term]
id: GO:0071044
name: histone mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA)." [GOC:df, GOC:krc, PMID:17179095, PMID:17855393]
is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process
is_a: GO:0008334 ! histone mRNA metabolic process

[Term]
id: GO:0071045
name: nuclear histone mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA) within the nucleus." [GOC:df, GOC:krc, PMID:17179095, PMID:17855393]
is_a: GO:0071044 ! histone mRNA catabolic process

[Term]
id: GO:0071046
name: nuclear polyadenylation-dependent ncRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA." [GOC:df, GOC:jl, GOC:krc, PMID:17410208]
is_a: GO:0043634 ! polyadenylation-dependent ncRNA catabolic process
is_a: GO:0071029 ! nuclear ncRNA surveillance

[Term]
id: GO:0071047
name: polyadenylation-dependent mRNA catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:kf, GOC:krc]
is_a: GO:0043633 ! polyadenylation-dependent RNA catabolic process

[Term]
id: GO:0071048
name: nuclear retention of unspliced pre-mRNA at the site of transcription
namespace: biological_process
def: "The process involved in retention of incorrectly or incompletely spliced pre-mRNA within the nucleus at the site of transcription." [GOC:kf, GOC:krc, PMID:14718167]
is_a: GO:0071033 ! nuclear retention of pre-mRNA at the site of transcription
relationship: part_of GO:0071030 ! nuclear mRNA surveillance of spliceosomal pre-mRNA splicing

[Term]
id: GO:0071049
name: nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription
namespace: biological_process
def: "The process involved in retention of mRNAs that have incorrectly formed 3'-ends within the nucleus at the site of transcription." [GOC:kf, GOC:krc, PMID:11586364, PMID:12417728]
is_a: GO:0071033 ! nuclear retention of pre-mRNA at the site of transcription
relationship: part_of GO:0071031 ! nuclear mRNA surveillance of mRNA 3'-end processing

[Term]
id: GO:0071050
name: snoRNA polyadenylation
namespace: biological_process
def: "The enzymatic addition of a sequence of adenylyl residues at the 3' end of snoRNA molecule. In eukaryotes, this occurs in conjunction with termination of transcription of precursor snoRNA molecules and may occur post-transcriptionally on incorrectly processed molecules targeted for degradation." [GOC:kf, GOC:krc, PMID:18951092]
is_a: GO:0043629 ! ncRNA polyadenylation

[Term]
id: GO:0071051
name: polyadenylation-dependent snoRNA 3'-end processing
namespace: biological_process
def: "Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA." [GOC:kf, GOC:krc, PMID:18951092]
is_a: GO:0031126 ! snoRNA 3'-end processing

[Term]
id: GO:0071052
name: alpha9-beta1 integrin-ADAM1 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM1." [PMID:11882657]
synonym: "ITGA9-ITGB1-ADAM1 complex" NARROW [CORUM:2964]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071053
name: alpha9-beta1 integrin-ADAM2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM2." [PMID:11882657]
synonym: "ITGA9-ITGB1-ADAM2 complex" NARROW [CORUM:2441]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071054
name: alpha9-beta1 integrin-ADAM3 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM3." [PMID:11882657]
synonym: "ITGA9-ITGB1-ADAM3 complex" NARROW [CORUM:2965]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071055
name: alpha9-beta1 integrin-ADAM9 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM9." [PMID:11882657]
synonym: "ITGA9-ITGB1-ADAM9 complex" NARROW [CORUM:2440]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071056
name: alpha9-beta1 integrin-ADAM15 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM15." [PMID:11882657]
synonym: "ITGA9-ITGB1-ADAM15 complex" NARROW [CORUM:2445]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071057
name: alphav-beta3 integrin-ADAM15 complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM15." [PMID:10944520, PMID:11882657]
synonym: "ITGAV-ITGB3-ADAM15 complex" NARROW [CORUM:2359]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071058
name: alpha3-beta1 integrin-CD151 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD151." [PMID:10811835, PMID:11884516]
synonym: "ITGA3-ITGB1-CD151 complex" NARROW [CORUM:2400]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071059
name: alpha6-beta1 integrin-CD151 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta1 integrin complex bound to the tetraspanin CD151." [PMID:11884516]
synonym: "ITGA6-ITGB1-CD151 complex" NARROW [CORUM:2411]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071060
name: alpha7-beta1 integrin-CD151 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to the tetraspanin CD151." [PMID:11884516]
synonym: "ITGA7-ITGB1-CD151 complex" NARROW [CORUM:2395]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071061
name: alpha6-beta4 integrin-CD151 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the tetraspanin CD151." [PMID:10811835]
synonym: "ITGA6-ITGB4-CD151 complex" NARROW [CORUM:2320]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071062
name: alphav-beta3 integrin-vitronectin complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to vitronectin." [PMID:10835423]
synonym: "ITGAV-ITGB3-VTN complex" NARROW [CORUM:2826]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071063
name: sensory perception of wind
namespace: biological_process
def: "The series of events required for an organism to receive sensory mechanical stimulus resulting from air flow, convert it to a molecular signal, and recognize and characterize the signal." [GOC:mah, PMID:19279637]
synonym: "perception of wind" EXACT [GOC:mah]
synonym: "sensory perception of air flow" EXACT [GOC:mah, PMID:19279637]
is_a: GO:0050954 ! sensory perception of mechanical stimulus

[Term]
id: GO:0071064
name: alphaE-beta7 integrin-E-cadherin complex
namespace: cellular_component
def: "A protein complex that consists of an alphaE-beta7 integrin complex bound to E-cadherin." [PMID:10837471]
synonym: "ITGAE-ITGB7-CDH1 complex" NARROW [CORUM:1834]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071065
name: alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1." [PMID:10209034]
synonym: "ITGA9-ITGB1-VCAM1 complex" NARROW [CORUM:2442]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071066
name: detection of mechanical stimulus involved in sensory perception of wind
namespace: biological_process
def: "The series of events involved in the perception of wind in which a sensory mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:mah, PMID:19279637]
synonym: "detection of mechanical stimulus involved in sensory perception of air flow" EXACT [GOC:mah]
synonym: "detection of wind" EXACT [GOC:mah]
synonym: "perception of wind, detection of mechanical stimulus" EXACT [GOC:mah]
synonym: "perception of wind, sensory detection of mechanical stimulus" EXACT [GOC:mah]
synonym: "perception of wind, sensory transduction of mechanical stimulus" EXACT [GOC:mah]
synonym: "sensory detection of mechanical stimulus during perception of wind" EXACT [GOC:mah]
synonym: "sensory transduction of mechanical stimulus during perception of wind" EXACT [GOC:mah]
synonym: "sensory transduction of wind" EXACT [GOC:mah]
is_a: GO:0050877 ! neurological system process
is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception
relationship: part_of GO:0071063 ! sensory perception of wind

[Term]
id: GO:0071067
name: alphav-beta3 integrin-ADAM23 complex
namespace: cellular_component
def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM23." [PMID:10749942]
synonym: "ITGAV-ITGB3-ADAM23 complex" NARROW [CORUM:2364]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071068
name: alpha9-beta1 integrin-ADAM12 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM12." [PMID:10944520]
synonym: "ITGA9-ITGB1-ADAM12 complex" NARROW [CORUM:2447]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071069
name: alpha4-beta1 integrin-thrombospondin-1 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-1." [PMID:11980922]
synonym: "ITGA4-ITGB1-THBS1 complex" NARROW [CORUM:2426]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071070
name: alpha4-beta1 integrin-thrombospondin-2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-2." [PMID:11980922]
synonym: "ITGA4-ITGB1-THBS2 complex" NARROW [CORUM:2428]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071071
name: regulation of phospholipid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah]
subset: gosubset_prok
synonym: "regulation of phospholipid anabolism" EXACT [GOC:mah]
synonym: "regulation of phospholipid biosynthesis" EXACT [GOC:mah]
synonym: "regulation of phospholipid formation" EXACT [GOC:mah]
synonym: "regulation of phospholipid synthesis" EXACT [GOC:mah]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: regulates GO:0008654 ! phospholipid biosynthetic process

[Term]
id: GO:0071072
name: negative regulation of phospholipid biosynthetic process
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah]
subset: gosubset_prok
synonym: "down regulation of phospholipid biosynthetic process" EXACT [GOC:mah]
synonym: "down-regulation of phospholipid biosynthetic process" EXACT [GOC:ma]
synonym: "downregulation of phospholipid biosynthetic process" EXACT [GOC:mah]
synonym: "inhibition of phospholipid biosynthetic process" NARROW [GOC:mah]
synonym: "negative regulation of phospholipid anabolism" EXACT [GOC:mah]
synonym: "negative regulation of phospholipid biosynthesis" EXACT [GOC:mah]
synonym: "negative regulation of phospholipid formation" EXACT [GOC:mah]
synonym: "negative regulation of phospholipid synthesis" EXACT [GOC:mah]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
relationship: negatively_regulates GO:0008654 ! phospholipid biosynthetic process

[Term]
id: GO:0071073
name: positive regulation of phospholipid biosynthetic process
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah]
subset: gosubset_prok
synonym: "activation of phospholipid biosynthetic process" NARROW [GOC:mah]
synonym: "positive regulation of phospholipid anabolism" EXACT [GOC:mah]
synonym: "positive regulation of phospholipid biosynthesis" EXACT [GOC:mah]
synonym: "positive regulation of phospholipid formation" EXACT [GOC:mah]
synonym: "positive regulation of phospholipid synthesis" EXACT [GOC:mah]
synonym: "stimulation of phospholipid biosynthetic process" NARROW [GOC:mah]
synonym: "up regulation of phospholipid biosynthetic process" EXACT [GOC:mah]
synonym: "up-regulation of phospholipid biosynthetic process" EXACT [GOC:mah]
synonym: "upregulation of phospholipid biosynthetic process" EXACT [GOC:mah]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0071071 ! regulation of phospholipid biosynthetic process
relationship: positively_regulates GO:0008654 ! phospholipid biosynthetic process

[Term]
id: GO:0071074
name: eukaryotic initiation factor eIF2 binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd]
is_a: GO:0031369 ! translation initiation factor binding

[Term]
id: GO:0071075
name: CUGBP1-eIF2 complex
namespace: cellular_component
def: "A protein complex that contains the eukaryotic translation initiation factor 2 complex (EIF2), CUG binding protein 1, and several endoplasmic reticulum proteins; the complex is involved in the regulation of translation." [PMID:16931514]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0071076
name: RNA 3' uridylation
namespace: biological_process
def: "The enzymatic addition of a sequence of uridylyl residues at the 3' end of an RNA molecule." [GOC:vw, PMID:19430462]
is_a: GO:0031123 ! RNA 3'-end processing

[Term]
id: GO:0071077
name: adenosine 3',5'-bisphosphate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of adenosine 3',5'-bisphosphate from one side of a membrane to the other." [ChEBI:37240, GOC:mah, PubChem:159296]
synonym: "adenosine 3',5'-diphosphate transporter activity" EXACT [PubChem:159296]
synonym: "adenosine 3'-phosphate-5'-phosphate transmembrane transporter activity" EXACT [PubChem:159296]
is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity

[Term]
id: GO:0071078
name: fibronectin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of fibronectin bound to tissue transglutaminase, and is involved in cell adhesion." [PMID:10684262]
synonym: "FN-TGM2 complex" NARROW [CORUM:2375]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071079
name: alpha2-beta1 integrin-chondroadherin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to the cartilage matrix protein chondroadherin." [PMID:9281592]
synonym: "ITGA2-ITGB1-CHAD complex" NARROW [CORUM:2430]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071080
name: alpha3-beta1 integrin-basigin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the cell surface protein basigin." [PMID:9360995]
synonym: "ITGA3-ITGB1-BSG complex" NARROW [CORUM:2398]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071081
name: alpha3-beta1 integrin-CD63 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD63." [PMID:7629079]
synonym: "ITGA3-ITGB1-CD63 complex" NARROW [CORUM:2399]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071082
name: alpha9-beta1 integrin-tenascin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the extracellular matrix protein tenascin." [PMID:9565552]
synonym: "ITGA9-ITGB1-TNC complex" NARROW [CORUM:2443]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071083
name: alphaV-beta3 integrin-CD47-FCER2 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface protein CD47 and the low-affinity immunoglobulin epsilon Fc receptor (FCER2)." [PMID:10037797]
synonym: "ITGAV-ITGB3-CD447-FCER2 complex" NARROW [CORUM:2355]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071084
name: alpha2-beta1 integrin-CD47 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to the cell surface protein CD47." [PMID:10397731]
synonym: "ITGA2-ITGB1-CD47 complex" NARROW [CORUM:2429]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071085
name: alphaIIb-beta3 integrin-CD9 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface protein CD9." [PMID:10429193]
synonym: "ITGA2b-ITGB3-CD9 complex" NARROW [CORUM:2370]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071086
name: alphaIIb-beta3 integrin-CD9-CD47-platelet glycoprotein Ib complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface proteins CD9 and CD47, and the heterodimeric platelet glycoprotein Ib." [PMID:10429193]
synonym: "ITGA2b-ITGB3-CD9-GP1b-CD47 complex" NARROW [CORUM:2872]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071087
name: alpha11-beta1 integrin-collagen type I complex
namespace: cellular_component
def: "A protein complex that consists of an alpha11-beta1 integrin complex bound to a type I collagen." [PMID:10464311]
synonym: "ITGA11-ITGB1-COL1A1 complex" NARROW [CORUM:3059]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071088
name: alpha5-beta1 integrin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262]
synonym: "ITGA5-ITGB1-TGM2 complex" NARROW [CORUM:2433]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071089
name: alphaV-beta3 integrin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to tissue transglutaminase." [PMID:10684262]
synonym: "ITGAV-ITGB3-TGM2 complex" NARROW [CORUM:3095]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071090
name: alphaIIb-beta3 integrin-fibronectin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to fibronectin and tissue transglutaminase." [PMID:10684262]
synonym: "ITGA2b-ITGB3-FN1-TGM2 complex" NARROW [CORUM:2376]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071091
name: alpha1-beta1 integrin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262]
synonym: "ITGA1-ITGB1-TGM2 complex" NARROW [CORUM:2894]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071092
name: alpha3-beta1 integrin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262]
synonym: "ITGA3-ITGB1-TGM2 complex" NARROW [CORUM:2402]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071093
name: alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and tissue transglutaminase." [PMID:10684262]
synonym: "ITGA5-ITGB1-FN1-TGM2 complex" NARROW [CORUM:2383]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071094
name: alpha6-beta4 integrin-CD9 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the cell surface protein CD9." [PMID:10711425]
synonym: "ITGA6-ITGB4-CD9 complex" NARROW [CORUM:2770]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071095
name: alpha3-beta1 integrin-thrombospondin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to thrombospondin." [PMID:11358957]
synonym: "ITGA3-ITGB1-THBS1 complex" NARROW [CORUM:2401]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071096
name: alphaV-beta3 integrin-gelsolin complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to gelsolin." [PMID:11577104]
synonym: "ITGAV-ITGB3-Gsn complex" NARROW [CORUM:2360]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071097
name: alphaV-beta3 integrin-paxillin-Pyk2 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to paxillin and the FAK-related kinase Pyk2." [PMID:11683411]
synonym: "ITGAV-ITGB3-PXN-PTK2b complex" NARROW [CORUM:2363]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071098
name: alpha6-beta4 integrin-Fyn complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the Src family tyrosine kinase Fyn." [PMID:11684709]
synonym: "ITGA6-ITGB4-FYN complex" NARROW [CORUM:2321]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071099
name: alphaV-beta6 integrin-TGFbeta-3 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta6 integrin complex bound to transforming growth factor beta-3 (TGFbeta-3)." [PMID:11821050]
synonym: "ITGAV-ITGB6-TFGB3 complex" NARROW [CORUM:2353]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071100
name: alphaV-beta8 integrin-MMP14-TGFbeta-1 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta8 integrin complex bound to matrix metalloproteinase 14 and transforming growth factor beta-1 (TGFbeta-1)." [PMID:11970960]
synonym: "ITGAV-ITGB8-MMP14-TGFB1 complex" NARROW [CORUM:2342]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071101
name: alpha4-beta1 integrin-JAM2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell adhesion molecule JAM2." [PMID:12070135]
synonym: "ITGA4-ITGB1-JAM2 complex" NARROW [CORUM:2422]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071102
name: alpha4-beta1 integrin-paxillin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to paxillin." [PMID:12221126]
synonym: "ITGA4-ITGB1-PXN complex" NARROW [CORUM:2425]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071103
name: DNA conformation change
namespace: biological_process
def: "A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule." [GOC:mah]
subset: gosubset_prok
synonym: "DNA conformation modification" EXACT [GOC:mah]
is_a: GO:0009987 ! cellular process

[Term]
id: GO:0071104
name: response to interleukin-9
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus." [GOC:mah]
synonym: "response to IL-9" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine stimulus

[Term]
id: GO:0071105
name: response to interleukin-11
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus." [GOC:mah]
synonym: "response to IL-11" EXACT [GOC:mah]
is_a: GO:0034097 ! response to cytokine stimulus

[Term]
id: GO:0071106
name: adenosine 3',5'-bisphosphate transmembrane transport
namespace: biological_process
def: "The directed movement of adenosine 3',5'-bisphosphate across a membrane into, out of, within or between cells by means of some external agent such as a transporter or pore." [ChEBI:37240, GOC:mah, PubChem:159296]
synonym: "adenosine 3',5'-diphosphate transport" EXACT [PubChem:159296]
synonym: "adenosine 3'-phosphate-5'-phosphate transmembrane transport" EXACT [PubChem:159296]
is_a: GO:0015860 ! purine nucleoside transport
is_a: GO:0055085 ! transmembrane transport

[Term]
id: GO:0071107
name: response to parathyroid hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus." [GOC:mah]
is_a: GO:0009725 ! response to hormone stimulus

[Term]
id: GO:0071108
name: protein K48-linked deubiquitination
namespace: biological_process
def: "A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein." [GOC:mah]
is_a: GO:0016579 ! protein deubiquitination

[Term]
id: GO:0071109
name: superior temporal gyrus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the superior temporal gyrus over time, from its formation to the mature structure. The superior temporal gyrus is a portion of the cerebral cortex that extends from the lateral sulcus to the superior temporal sulcus." [FMA:61905, GOC:BHF, GOC:mah, PMID:11484000]
comment: This term was added by GO_REF:0000021.
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0021987 ! cerebral cortex development

[Term]
id: GO:0071110
name: histone biotinylation
namespace: biological_process
def: "The modification of a histone by the addition of a biotinyl group." [GOC:rph, PMID:14613969, PMID:19019041]
is_a: GO:0006473 ! protein amino acid acetylation
is_a: GO:0016570 ! histone modification

[Term]
id: GO:0071111
name: cyclic-guanylate-specific phosphodiesterase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine." [EC:3.1.4.52, MetaCyc:RXN0-4181]
subset: gosubset_prok
synonym: "c-di-GMP phosphodiesterase activity" EXACT [EC:3.1.4.52]
synonym: "c-di-GMP-specific phosphodiesterase activity" EXACT [EC:3.1.4.52]
synonym: "cyclic bis(3->5')diguanylate phosphodiesterase activity" EXACT [EC:3.1.4.52]
synonym: "PDEA1" RELATED [EC:3.1.4.52]
synonym: "phosphodiesterase A1 activity" RELATED [EC:3.1.4.52]
synonym: "VieA" RELATED [EC:3.1.4.52]
xref: EC:3.1.4.52
xref: MetaCyc:RXN0-4181
is_a: GO:0008081 ! phosphoric diester hydrolase activity

[Term]
id: GO:0071112
name: alpha4-beta4 integrin-EMILIN-1 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta4 integrin complex bound to EMILIN-1 (ElastinMicrofibril Interface Located ProteIN)." [PMID:12456677]
synonym: "ITGA4-ITGB4-EMILIN1 complex" NARROW [CORUM:2417]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071113
name: alphaIIb-beta3 integrin-ICAM-4 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell adhesion molecule ICAM-4." [PMID:12477717]
synonym: "ITGAIIb-ITGB3-ICAM4 complex" NARROW [CORUM:3115]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071114
name: alphaV-beta3 integrin-tumstatin complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to tumstatin, the NC1 domain of the alpha3 chain of type IV collagen." [PMID:12682293]
synonym: "ITGAV-ITGB3-COL4A3 complex" NARROW [CORUM:2365]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071115
name: alpha5-beta1 integrin-endostatin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to endostatin, the NC1 domain of the alpha1 chain of type XVIII collagen." [PMID:12682293]
synonym: "ITGA5-ITGB1-CAL4A3 complex" NARROW [CORUM:2853]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071116
name: alpha6-beta1 integrin-CYR61 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha6-beta1 integrin complex bound to CYR61, a cysteine-rich protein involved in angiogenesis." [PMID:12826661]
synonym: "ITGA6-ITGB1-CYR61 complex" NARROW [CORUM:2437]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071117
name: alpha5-beta1 integrin-fibronectin-NOV complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and the extracellular matrix protein NOV." [PMID:12902636]
synonym: "ITGA5-ITGB1-FN-1-NOV complex" NARROW [CORUM:2850]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071118
name: alphaV-beta3 integrin-NOV complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the extracellular matrix protein NOV." [PMID:12902636]
synonym: "ITGAV-ITGB3-FN-1-NOV complex" NARROW [CORUM:2849]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071119
name: alpha7-beta1 integrin-nicotinamide riboside kinase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to nicotinamide riboside kinase 2 (also known as muscle integrin binding protein, MIBP)." [PMID:12941630]
synonym: "ITGA7-ITGB1-ITGB1BP3 complex" NARROW [CORUM:2397]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071120
name: alpha4-beta1 integrin-CD47 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell surface antigen CD47." [PMID:15292185]
synonym: "ITGA4-ITGB1-CB47 complex" NARROW [CORUM:2423]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071121
name: alpha9-beta1 integrin-VEGF-D complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor D." [PMID:15590642]
synonym: "ITGA9-ITGB1-FIGF complex" NARROW [CORUM:2446]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071122
name: alpha9-beta1 integrin-VEGF-A complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor A." [PMID:17363377]
synonym: "ITGA9-ITGB1-VEGFA complex" NARROW [CORUM:2972]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071123
name: alpha9-beta1 integrin-VEGF-C complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor C." [PMID:15590642]
synonym: "ITGA9-ITGB1-VEGFC complex" NARROW [CORUM:2971]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071124
name: alpha1-beta1 integrin-tyrosine-protein phosphatase non-receptor type 2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to tyrosine-protein phosphatase non-receptor type 2." [PMID:15592458]
synonym: "ITGA1-ITGB1-PTPN2 complex" NARROW [CORUM:2435]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071125
name: alphaV-beta3 integrin-EGFR complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to epidermal growth factor receptor." [PMID:15834425]
synonym: "ITGAV-ITGB3-EGFR complex" NARROW [CORUM:2369]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071126
name: alphaV-beta6 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta6 integrin complex bound to osteopontin." [PMID:16005200]
synonym: "ITGAV-ITGB6-SPP1 complex" NARROW [CORUM:2352]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071127
name: alpha9-beta1 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to osteopontin." [PMID:16005200]
synonym: "ITGA9-ITGB1-SPP1 complex" NARROW [CORUM:3111]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071128
name: alpha5-beta1 integrin-osteopontin complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to osteopontin." [PMID:16005200]
synonym: "ITGA5-ITGB1-SPP1 complex" NARROW [CORUM:3112]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071129
name: alphaV-beta3 integrin-LPP3 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to lipid phosphate phosphohydrolase-3." [PMID:16099422]
synonym: "ITGAV-ITGB3-PPAP2B complex" NARROW [CORUM:2366]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071130
name: alpha5-beta1 integrin-LPP3 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to lipid phosphate phosphohydrolase-3." [PMID:16099422]
synonym: "ITGA5-ITGB1-PPAP2B complex" NARROW [CORUM:2386]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071131
name: alphaV-beta3 integrin-laminin alpha-4 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4." [PMID:16824487]
synonym: "ITGAV-ITGB3-LAMA4 complex" NARROW [CORUM:2374]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071132
name: alphaX-beta2 integrin-ICAM-4 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaX-beta2 integrin complex bound to intercellular adhesion molecule 4." [PMID:16985175]
synonym: "ITGAX-ITGB2-ICAM4 complex" NARROW [CORUM:3114]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071133
name: alpha9-beta1 integrin-ADAM8 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8." [PMID:16995821]
synonym: "ITGA9-ITGB1-ADAM8 complex" NARROW [CORUM:2989]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071134
name: alpha9-beta1 integrin-thrombospondin-1 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to thrombospondin-1." [PMID:17413041]
synonym: "ITGA9-ITGB1-THBS1 complex" NARROW [CORUM:2967]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071135
name: alpha7-beta1 integrin-focal adhesion kinase complex
namespace: cellular_component
def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to focal adhesion kinase." [PMID:17598176]
synonym: "ITGA7-ITGB1-PTK2 complex" NARROW [CORUM:3106]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071136
name: alpha7-beta1 integrin-laminin alpha-2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to laminin alpha-2." [PMID:17598176]
synonym: "ITGA7-ITGB1-LAMA2 complex" NARROW [CORUM:3105]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071137
name: alphaV-beta3 integrin-CD98 complex
namespace: cellular_component
def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface antigen CD98." [PMID:18032696]
synonym: "ITGAV-ITGB3-SLC3A2 complex" NARROW [CORUM:3103]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071138
name: alpha5-beta5-fibronectin-SFRP2 complex
namespace: cellular_component
def: "A protein complex that consists of an alpha5-beta5 integrin complex bound to fibronectin and secreted frizzled-related protein 2." [PMID:14709558]
synonym: "ITGA5-ITGB5-FN-1-SFRP2 complex" NARROW [CORUM:2388]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071139
name: resolution of recombination intermediates
namespace: biological_process
def: "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during DNA recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, GOC:mah, GOC:vw]
is_a: GO:0051304 ! chromosome separation
relationship: part_of GO:0006310 ! DNA recombination

[Term]
id: GO:0071140
name: resolution of mitotic recombination intermediates
namespace: biological_process
def: "The cleavage and rejoining of intermediates, mitotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, GOC:mah, GOC:vw]
is_a: GO:0071139 ! resolution of recombination intermediates
relationship: part_of GO:0006312 ! mitotic recombination

[Term]
id: GO:0071141
name: SMAD protein complex
namespace: cellular_component
def: "A protein complex that consists of SMAD proteins; may be homomeric or heteromeric." [GOC:mah, PMID:9670020]
synonym: "SMAD complex" EXACT [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0071142
name: SMAD2 protein complex
namespace: cellular_component
def: "A protein complex that consists of a SMAD2 homotrimer." [GOC:mah, PMID:9670020]
synonym: "SMAD2 homotrimer complex" EXACT [CORUM:2999]
is_a: GO:0071141 ! SMAD protein complex

[Term]
id: GO:0071143
name: SMAD3 protein complex
namespace: cellular_component
def: "A protein complex that consists of a SMAD3 homotrimer." [GOC:mah, PMID:9670020]
synonym: "SMAD3 homotrimer complex" EXACT [CORUM:3003]
is_a: GO:0071141 ! SMAD protein complex

[Term]
id: GO:0071144
name: SMAD2-SMAD3 protein complex
namespace: cellular_component
def: "A heteromeric SMAD protein complex that contains SMAD2 and SMAD3." [GOC:mah, PMID:9670020]
synonym: "SMAD2-SMAD3 complex" EXACT [CORUM:3000]
is_a: GO:0071141 ! SMAD protein complex

[Term]
id: GO:0071145
name: SMAD2-SMAD4 protein complex
namespace: cellular_component
def: "A heteromeric SMAD protein complex that contains SMAD2 and SMAD4." [GOC:mah, PMID:9670020]
synonym: "SMAD2-SMAD4 heteromer complex" EXACT [CORUM:3001]
is_a: GO:0071141 ! SMAD protein complex

[Term]
id: GO:0071146
name: SMAD3-SMAD4 protein complex
namespace: cellular_component
def: "A heteromeric SMAD protein complex that contains SMAD3 and SMAD4." [GOC:mah, PMID:9670020]
synonym: "SMAD3-SMAD4 complex" EXACT [CORUM:3002]
is_a: GO:0071141 ! SMAD protein complex

[Term]
id: GO:0071147
name: TEAD-2 multiprotein complex
namespace: cellular_component
def: "A protein complex that consists of the DNA binding protein TEAD-2 bound to 12 other polypeptides including the transcriptional coactivator YAP, the multi-PDZ domain protein MPDZ (also called MUPP1), a 14-3-3 domain protein, and others." [CORUM:2870, GOC:mah, PMID:11358867]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0071148
name: TEAD-1-YAP complex
namespace: cellular_component
def: "A transcription factor complex that is composed of the DNA biding protein TEAD-1 and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0071149
name: TEAD-2-YAP complex
namespace: cellular_component
def: "A transcription factor complex that is composed of the DNA biding protein TEAD-2 and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0071150
name: TEAD-3-YAP complex
namespace: cellular_component
def: "A transcription factor complex that is composed of the DNA biding protein TEAD-3 and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0071151
name: TEAD-4-YAP complex
namespace: cellular_component
def: "A transcription factor complex that is composed of the DNA biding protein TEAD-4 and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867]
is_a: GO:0005667 ! transcription factor complex

[Term]
id: GO:0071152
name: G-protein alpha(q)-synembrin complex
namespace: cellular_component
def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(q) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430]
synonym: "Ric-8A G(q) alpha subunit complex" NARROW [CORUM:175]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0071153
name: G-protein alpha(o)-synembrin complex
namespace: cellular_component
def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(o) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430]
synonym: "Ric-8A G(o) alpha-1 subunit complex" NARROW [CORUM:172]
synonym: "Ric-8A G(o) alpha-2 subunit complex" NARROW [CORUM:174]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0071154
name: G-protein alpha(i)1-synembrin complex
namespace: cellular_component
def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(i)1 subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430]
synonym: "Ric-8A G(i) alpha-1 subunit complex" NARROW [CORUM:170]
synonym: "Ric-8A G(i) alpha-2 subunit complex" RELATED [CORUM:171]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0071155
name: G-protein alpha(13)-synembrin complex
namespace: cellular_component
def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(13) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430]
synonym: "Ric-8A G alpha 13 subunit complex" NARROW [CORUM:176]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0071156
name: regulation of cell cycle arrest
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cell cycle arrest, the process by which the cell cycle is halted during one of the normal phases." [GOC:mah]
is_a: GO:0010564 ! regulation of cell cycle process
relationship: regulates GO:0007050 ! cell cycle arrest

[Term]
id: GO:0071157
name: negative regulation of cell cycle arrest
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cell cycle arrest, the process by which the cell cycle is halted during one of the normal phases." [GOC:mah]
is_a: GO:0010948 ! negative regulation of cell cycle process
is_a: GO:0071156 ! regulation of cell cycle arrest
relationship: negatively_regulates GO:0007050 ! cell cycle arrest

[Term]
id: GO:0071158
name: positive regulation of cell cycle arrest
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of cell cycle arrest, the process by which the cell cycle is halted during one of the normal phases." [GOC:mah]
is_a: GO:0071156 ! regulation of cell cycle arrest
is_a: GO:0090068 ! positive regulation of cell cycle process
relationship: positively_regulates GO:0007050 ! cell cycle arrest

[Term]
id: GO:0071159
name: NF-kappaB complex
namespace: cellular_component
def: "A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression." [ISBN:0849327946]
is_a: GO:0043234 ! protein complex
is_a: GO:0044424 ! intracellular part

[Term]
id: GO:0071160
name: cyanophycin synthetase activity (L-aspartate-adding)
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp." [EC:6.3.2.29]
subset: gosubset_prok
xref: EC:6.3.1.29
is_a: GO:0043860 ! cyanophycin synthetase activity

[Term]
id: GO:0071161
name: cyanophycin synthetase activity (L-arginine-adding)
namespace: molecular_function
def: "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-Arg = ADP + phosphate + [L-Asp(4-L-Arg)]n+1." [EC:6.3.2.30]
subset: gosubset_prok
xref: EC:6.3.1.30
is_a: GO:0043860 ! cyanophycin synthetase activity

[Term]
id: GO:0071162
name: CMG complex
namespace: cellular_component
def: "A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [PMID:19228417]
synonym: "unwindosome" EXACT [PMID:19228417]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part
is_a: GO:0044454 ! nuclear chromosome part

[Term]
id: GO:0071163
name: DNA replication preinitiation complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication, by the assembly of additional proteins onto an existing prereplicative complex." [GOC:mah]
synonym: "DNA replication preinitiation complex formation" EXACT [GOC:mah]
is_a: GO:0065004 ! protein-DNA complex assembly
relationship: part_of GO:0006261 ! DNA-dependent DNA replication

[Term]
id: GO:0071164
name: RNA trimethylguanosine synthase activity
namespace: molecular_function
def: "Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine." [GOC:BHF, PMID:11983179, PMID:18775984]
synonym: "cap hypermethylase activity" EXACT [PMID:11983179]
synonym: "small nuclear RNA methyltransferase activity" RELATED [GOC:rl]
synonym: "snRNA methyltransferase activity" RELATED [GOC:rl]
is_a: GO:0008173 ! RNA methyltransferase activity

[Term]
id: GO:0071165
name: GINS complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a GINS complex, a heterotetrameric protein complex that associates with DNA replication origins and replication forks." [GOC:mah, PMID:16990792]
is_a: GO:0043623 ! cellular protein complex assembly

[Term]
id: GO:0071166
name: ribonucleoprotein complex localization
namespace: biological_process
def: "Any process by which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell." [GOC:mah]
synonym: "cellular ribonucleoprotein complex localization" EXACT [GOC:mah]
synonym: "establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:mah]
synonym: "RNP localization" EXACT [GOC:mah]
is_a: GO:0051641 ! cellular localization

[Term]
id: GO:0071167
name: ribonucleoprotein complex import into nucleus
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex from the cytoplasm to the nucleus." [GOC:BHF, GOC:mah]
synonym: "ribonucleoprotein complex import into cell nucleus" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex nucleus import" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex targeting to nucleus" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex transport from cytoplasm to nucleus" EXACT [GOC:mah]
synonym: "ribonucleoprotein import into nucleus" EXACT [GOC:rl]
synonym: "RNP import into nucleus" EXACT [GOC:mah]
is_a: GO:0051170 ! nuclear import
is_a: GO:0071166 ! ribonucleoprotein complex localization

[Term]
id: GO:0071168
name: protein localization to chromatin
namespace: biological_process
def: "Any process by which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome

[Term]
id: GO:0071169
name: establishment of protein localization to chromatin
namespace: biological_process
def: "The directed movement of a protein to a part of a chromosome that is organized into chromatin." [GOC:mah]
is_a: GO:0070199 ! establishment of protein localization to chromosome
relationship: part_of GO:0071168 ! protein localization to chromatin

[Term]
id: GO:0071170
name: site-specific DNA replication termination
namespace: biological_process
def: "A DNA replication termination process that takes place at a specific termination site." [GOC:mah, PMID:12009298, PMID:18723894]
comment: See also the biological process term 'replication fork arrest ; GO:0043111' and its children.
is_a: GO:0006274 ! DNA replication termination

[Term]
id: GO:0071171
name: site-specific DNA replication termination at RTS1 barrier
namespace: biological_process
def: "A DNA replication termination process that takes place at the RTS1 termination site in the mating type locus, in a specific direction required for subsequent imprinting and mating-type switching." [GOC:vw, PMID:12009298, PMID:18723894]
is_a: GO:0071170 ! site-specific DNA replication termination
relationship: part_of GO:0071516 ! establishment of imprinting at mating-type locus

[Term]
id: GO:0071172
name: dihydromonapterin reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7,8-dihydromonapterin + NADPH = tetrahydromonapterin + NADP+." [GOC:imk, PMID:19897652]
subset: gosubset_prok
is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

[Term]
id: GO:0071173
name: spindle assembly checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:mah]
synonym: "SAC" BROAD [GOC:mah]
is_a: GO:0031577 ! spindle checkpoint

[Term]
id: GO:0071174
name: mitotic cell cycle spindle checkpoint
namespace: biological_process
def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:mah]
synonym: "mitotic spindle checkpoint" EXACT [GOC:mah]
is_a: GO:0031577 ! spindle checkpoint

[Term]
id: GO:0071175
name: MAML2-RBP-Jkappa-ICN1 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML2-RBP-Jkappa-Notch1 complex" EXACT [CORUM:1949]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0071176
name: MAML2-RBP-Jkappa-ICN2 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML2-RBP-Jkappa-Notch2 complex" EXACT [CORUM:3217]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0071177
name: MAML2-RBP-Jkappa-ICN3 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML2-RBP-Jkappa-Notch3 complex" EXACT [CORUM:3218]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0071178
name: MAML2-RBP-Jkappa-ICN4 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML2-RBP-Jkappa-Notch4 complex" EXACT [CORUM:3219]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0071179
name: MAML3-RBP-Jkappa-ICN1 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML3-RBP-Jkappa-Notch1 complex" EXACT [CORUM:3220]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0071180
name: MAML3-RBP-Jkappa-ICN2 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML3-RBP-Jkappa-Notch2 complex" EXACT [CORUM:3221]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0071181
name: MAML3-RBP-Jkappa-ICN3 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML3-RBP-Jkappa-Notch3 complex" EXACT [CORUM:3222]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0071182
name: MAML3-RBP-Jkappa-ICN4 complex
namespace: cellular_component
def: "A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315]
synonym: "MAML3-RBP-Jkappa-Notch4 complex" EXACT [CORUM:3223]
is_a: GO:0043234 ! protein complex
is_a: GO:0044451 ! nucleoplasm part

[Term]
id: GO:0071183
name: protocadherin-alpha-protocadherin-gamma complex
namespace: cellular_component
def: "A protein complex that contains two cell adhesion molecules, a protocadherin-alpha and a protocadherin-gamma, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
is_a: GO:0043234 ! protein complex
is_a: GO:0044459 ! plasma membrane part

[Term]
id: GO:0071184
name: protocadherin-alpha-v4-protocadherin-gamma-a1 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdhga1-Pcdha4 complex" NARROW [CORUM:1014]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex

[Term]
id: GO:0071185
name: protocadherin-alpha-v4-protocadherin-gamma-a3 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdhga1-Pcdhga3 complex" NARROW [CORUM:1016]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex

[Term]
id: GO:0071186
name: protocadherin-alpha-v4-protocadherin-gamma-b2 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdhga1-Pcdhgb2 complex" NARROW [CORUM:1015]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex

[Term]
id: GO:0071187
name: protocadherin-alpha-v4-protocadherin-gamma-b4 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdhga1-Pcdhgb4 complex" NARROW [CORUM:1017]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex

[Term]
id: GO:0071188
name: protocadherin-alpha-v7-protocadherin-gamma-a1 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdha7-Pcdhga1 complex" NARROW [CORUM:1021]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex

[Term]
id: GO:0071189
name: protocadherin-alpha-v7-protocadherin-gamma-a3 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdha7-Pcdhga3 complex" NARROW [CORUM:1019]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex

[Term]
id: GO:0071190
name: protocadherin-alpha-v7-protocadherin-gamma-b2 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdha7-Pcdhgb4 complex" NARROW [CORUM:1018]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex

[Term]
id: GO:0071191
name: protocadherin-alpha-v7-protocadherin-gamma-b4 complex
namespace: cellular_component
def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688]
synonym: "Pcdha7-Pcdhgb2 complex" NARROW [CORUM:1020]
is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex

[Term]
id: GO:0071192
name: Kv4.2-KChIP1 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203]
xref: CORUM:606
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071193
name: Kv4.2-KChIP2 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP2 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203]
xref: CORUM:607
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071194
name: Kv4.2-KChIP3 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP3 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203]
xref: CORUM:608
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071195
name: Kv4.2-KChIP4 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP4 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203]
xref: CORUM:3090
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071196
name: Kv4.3-KChIP1 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:15356203]
xref: CORUM:3091
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071197
name: Kv4.2-Kv4.3 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the Kv alpha subunits 4.2 and 4.3." [PMID:15356203]
xref: CORUM:609
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071198
name: Kv4.1-DPP6 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.1." [PMID:15911355]
synonym: "Kv4.1-DPPX channel complex" EXACT [PMID:15911355]
xref: CORUM:600
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071199
name: Kv4.1-DPP10 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.1." [PMID:15911355]
synonym: "Kv4.1-DPPY channel complex" EXACT [PMID:15911355]
xref: CORUM:601
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071200
name: Kv4.2-DPP6 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:12575952, PMID:15911355]
synonym: "Kv4.2-DPPX channel complex" EXACT [PMID:15911355]
xref: CORUM:603
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071201
name: Kv4.3-DPP6 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:12575952, PMID:15911355]
synonym: "Kv4.3-DPPX channel complex" EXACT [PMID:15911355]
xref: CORUM:599
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071202
name: Kv4.3-DPP10 channel complex
namespace: cellular_component
def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:15911355]
synonym: "Kv4.3-DPPY channel complex" EXACT [PMID:15911355]
xref: CORUM:598
is_a: GO:0008076 ! voltage-gated potassium channel complex

[Term]
id: GO:0071203
name: WASH complex
namespace: cellular_component
def: "A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0071204
name: histone pre-mRNA 3'end processing complex
namespace: cellular_component
def: "A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1." [GOC:mah, PMID:19470752]
synonym: "histone 3'end pre-mRNA complex" EXACT [GOC:mah]
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044428 ! nuclear part

[Term]
id: GO:0071205
name: protein localization to juxtaparanode region of axon
namespace: biological_process
def: "Any process by which a protein is transported to, or maintained at, the juxtaparanode region of an axon." [GOC:BHF, GOC:mah]
is_a: GO:0034613 ! cellular protein localization

[Term]
id: GO:0071206
name: establishment of protein localization to juxtaparanode region of axon
namespace: biological_process
def: "The directed movement of a protein to the juxtaparanode region of an axon." [GOC:BHF, GOC:mah]
is_a: GO:0045184 ! establishment of protein localization
relationship: part_of GO:0071205 ! protein localization to juxtaparanode region of axon

[Term]
id: GO:0071207
name: histone pre-mRNA stem-loop binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a conserved stem-loop structure found in histone pre-mRNAs." [PMID:19470752]
is_a: GO:0003729 ! mRNA binding

[Term]
id: GO:0071208
name: histone pre-mRNA DCP binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing." [PMID:19470752]
is_a: GO:0003723 ! RNA binding

[Term]
id: GO:0071209
name: U7 snRNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the U7 small nuclear RNA (U7 snRNA)." [GOC:mah, PMID:12975319]
comment: Note that this term may be useful for annotating other small nuclear RNAs (snRNAs).
is_a: GO:0017069 ! snRNA binding

[Term]
id: GO:0071210
name: protein insertion into membrane raft
namespace: biological_process
def: "The process by which a protein is incorporated into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:mah]
synonym: "establishment of protein localization to membrane raft" EXACT [GOC:mah, GOC:vw]
is_a: GO:0051205 ! protein insertion into membrane

[Term]
id: GO:0071211
name: protein targeting to vacuole involved in autophagy
namespace: biological_process
def: "The process of directing proteins towards the vacuole using signals contained within the protein, occurring as part of autophagy, the process by which cells digest parts of their own cytoplasm." [GOC:mah]
is_a: GO:0006623 ! protein targeting to vacuole
relationship: part_of GO:0006914 ! autophagy

[Term]
id: GO:0071212
name: subsynaptic reticulum
namespace: cellular_component
def: "An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane." [PMID:1460464, PMID:18171947, PMID:19244343, PMID:7946331]
synonym: "SSR" EXACT [PMID:19244343]
is_a: GO:0043231 ! intracellular membrane-bounded organelle
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0071213
name: cellular response to 1-aminocyclopropane-1-carboxylic acid
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus." [GOC:mah]
is_a: GO:0009961 ! response to 1-aminocyclopropane-1-carboxylic acid
is_a: GO:0032870 ! cellular response to hormone stimulus

[Term]
id: GO:0071214
name: cellular response to abiotic stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to abiotic stress" NARROW [GOC:mah]
is_a: GO:0009628 ! response to abiotic stimulus
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0071215
name: cellular response to abscisic acid stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:mah]
is_a: GO:0009737 ! response to abscisic acid stimulus
is_a: GO:0032870 ! cellular response to hormone stimulus

[Term]
id: GO:0071216
name: cellular response to biotic stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:mah]
synonym: "cellular response to biotic stress" NARROW [GOC:mah]
is_a: GO:0009607 ! response to biotic stimulus
is_a: GO:0051716 ! cellular response to stimulus

[Term]
id: GO:0071217
name: cellular response to external biotic stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:mah]
is_a: GO:0043207 ! response to external biotic stimulus
is_a: GO:0071216 ! cellular response to biotic stimulus
is_a: GO:0071496 ! cellular response to external stimulus

[Term]
id: GO:0071218
name: cellular response to misfolded protein
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0051788 ! response to misfolded protein
is_a: GO:0071216 ! cellular response to biotic stimulus
is_a: GO:0071445 ! cellular response to protein stimulus

[Term]
id: GO:0071219
name: cellular response to molecule of bacterial origin
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:mah]
synonym: "cellular response to bacteria associated molecule" EXACT [GOC:mah]
synonym: "cellular response to bacterial associated molecule" EXACT [GOC:mah]
synonym: "cellular response to bacterium associated molecule" EXACT [GOC:mah]
is_a: GO:0002237 ! response to molecule of bacterial origin
is_a: GO:0071216 ! cellular response to biotic stimulus

[Term]
id: GO:0071220
name: cellular response to bacterial lipoprotein
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus." [GOC:mah]
is_a: GO:0032493 ! response to bacterial lipoprotein
is_a: GO:0071219 ! cellular response to molecule of bacterial origin

[Term]
id: GO:0071221
name: cellular response to bacterial lipopeptide
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus." [GOC:mah]
is_a: GO:0070339 ! response to bacterial lipopeptide
is_a: GO:0071220 ! cellular response to bacterial lipoprotein

[Term]
id: GO:0071222
name: cellular response to lipopolysaccharide
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah]
synonym: "cellular response to endotoxin" BROAD [GOC:mah, GOC:sl]
synonym: "cellular response to LPS" EXACT [GOC:mah]
is_a: GO:0032496 ! response to lipopolysaccharide
is_a: GO:0071219 ! cellular response to molecule of bacterial origin

[Term]
id: GO:0071223
name: cellular response to lipoteichoic acid
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:mah]
synonym: "cellular response to LTA" EXACT [GOC:mah]
is_a: GO:0070391 ! response to lipoteichoic acid
is_a: GO:0071219 ! cellular response to molecule of bacterial origin

[Term]
id: GO:0071224
name: cellular response to peptidoglycan
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:mah]
is_a: GO:0032494 ! response to peptidoglycan
is_a: GO:0071219 ! cellular response to molecule of bacterial origin

[Term]
id: GO:0071225
name: cellular response to muramyl dipeptide
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:mah]
is_a: GO:0032495 ! response to muramyl dipeptide
is_a: GO:0071224 ! cellular response to peptidoglycan

[Term]
id: GO:0071226
name: cellular response to molecule of fungal origin
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:mah]
synonym: "cellular response to fungus associated molecule" EXACT [GOC:mah]
is_a: GO:0002238 ! response to molecule of fungal origin
is_a: GO:0071216 ! cellular response to biotic stimulus

[Term]
id: GO:0071227
name: cellular response to molecule of oomycetes origin
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:mah]
synonym: "cellular response to oomycetes associated molecule" EXACT [GOC:mah]
is_a: GO:0002240 ! response to molecule of oomycetes origin
is_a: GO:0071216 ! cellular response to biotic stimulus
is_a: GO:0071310 ! cellular response to organic substance
relationship: part_of GO:0009620 ! response to fungus

[Term]
id: GO:0071228
name: cellular response to tumor cell
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:mah]
is_a: GO:0002347 ! response to tumor cell
is_a: GO:0071216 ! cellular response to biotic stimulus

[Term]
id: GO:0071229
name: cellular response to acid
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acid stimulus." [GOC:mah]
is_a: GO:0001101 ! response to acid
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071230
name: cellular response to amino acid stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [ChEBI:33709, GOC:mah]
synonym: "cellular response to amino acid" EXACT [GOC:mah]
is_a: GO:0043200 ! response to amino acid stimulus
is_a: GO:0071229 ! cellular response to acid
is_a: GO:0071418 ! cellular response to amine stimulus

[Term]
id: GO:0071231
name: cellular response to folic acid
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:mah]
synonym: "response to folate" EXACT [GOC:mah]
synonym: "response to vitamin B9" EXACT [GOC:mah]
is_a: GO:0051593 ! response to folic acid
is_a: GO:0071229 ! cellular response to acid
is_a: GO:0071295 ! cellular response to vitamin

[Term]
id: GO:0071232
name: cellular response to histidine
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus." [GOC:mah]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0080052 ! response to histidine

[Term]
id: GO:0071233
name: cellular response to leucine
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus." [GOC:mah]
is_a: GO:0043201 ! response to leucine
is_a: GO:0071230 ! cellular response to amino acid stimulus

[Term]
id: GO:0071234
name: cellular response to phenylalanine
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus." [GOC:mah]
is_a: GO:0071230 ! cellular response to amino acid stimulus
is_a: GO:0080053 ! response to phenylalanine

[Term]
id: GO:0071235
name: cellular response to proline
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus." [GOC:mah]
is_a: GO:0010238 ! response to proline
is_a: GO:0071230 ! cellular response to amino acid stimulus

[Term]
id: GO:0071236
name: cellular response to antibiotic
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:mah]
subset: gosubset_prok
is_a: GO:0046677 ! response to antibiotic
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071237
name: cellular response to bacteriocin
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation." [GOC:mah]
subset: gosubset_prok
is_a: GO:0046678 ! response to bacteriocin
is_a: GO:0071236 ! cellular response to antibiotic

[Term]
id: GO:0071238
name: cellular response to brefeldin A
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus." [GOC:mah]
is_a: GO:0031001 ! response to brefeldin A
is_a: GO:0071236 ! cellular response to antibiotic

[Term]
id: GO:0071239
name: cellular response to streptomycin
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GOC:mah]
is_a: GO:0046679 ! response to streptomycin
is_a: GO:0071236 ! cellular response to antibiotic

[Term]
id: GO:0071240
name: cellular response to food
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat." [GOC:mah]
is_a: GO:0032094 ! response to food
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071241
name: cellular response to inorganic substance
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:mah]
subset: gosubset_prok
is_a: GO:0010035 ! response to inorganic substance
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071242
name: cellular response to ammonium ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus." [GOC:mah]
is_a: GO:0060359 ! response to ammonium ion
is_a: GO:0071241 ! cellular response to inorganic substance

[Term]
id: GO:0071243
name: cellular response to arsenic
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:mah]
subset: gosubset_prok
is_a: GO:0046685 ! response to arsenic
is_a: GO:0071241 ! cellular response to inorganic substance

[Term]
id: GO:0071244
name: cellular response to carbon dioxide
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:mah]
is_a: GO:0010037 ! response to carbon dioxide
is_a: GO:0071241 ! cellular response to inorganic substance

[Term]
id: GO:0071245
name: cellular response to carbon monoxide
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:mah]
is_a: GO:0034465 ! response to carbon monoxide
is_a: GO:0071241 ! cellular response to inorganic substance

[Term]
id: GO:0071246
name: cellular response to chlorate
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:mah]
is_a: GO:0010157 ! response to chlorate
is_a: GO:0071241 ! cellular response to inorganic substance

[Term]
id: GO:0071247
name: cellular response to chromate
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus." [GOC:mah]
subset: gosubset_prok
is_a: GO:0046687 ! response to chromate
is_a: GO:0071241 ! cellular response to inorganic substance

[Term]
id: GO:0071248
name: cellular response to metal ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to heavy metal" NARROW [GOC:mah]
synonym: "cellular response to metal" EXACT [GOC:mah]
is_a: GO:0010038 ! response to metal ion
is_a: GO:0071241 ! cellular response to inorganic substance

[Term]
id: GO:0071249
name: cellular response to nitrate
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:mah]
is_a: GO:0010167 ! response to nitrate
is_a: GO:0071241 ! cellular response to inorganic substance

[Term]
id: GO:0071250
name: cellular response to nitrite
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:mah]
is_a: GO:0071241 ! cellular response to inorganic substance
is_a: GO:0080033 ! response to nitrite

[Term]
id: GO:0071251
name: cellular response to silicon dioxide
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus." [GOC:mah]
synonym: "cellular response to silica" EXACT [GOC:mah]
synonym: "cellular response to silox" EXACT [GOC:mah]
is_a: GO:0034021 ! response to silicon dioxide
is_a: GO:0071241 ! cellular response to inorganic substance

[Term]
id: GO:0071252
name: cellular response to sulfur dioxide
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus." [GOC:mah]
is_a: GO:0010477 ! response to sulfur dioxide
is_a: GO:0071241 ! cellular response to inorganic substance

[Term]
id: GO:0071253
name: connexin binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a connexin, any of a group of related proteins that assemble to form gap junctions." [GOC:mah, PMID:19864490]
is_a: GO:0005515 ! protein binding

[Term]
id: GO:0071254
name: cytoplasmic U snRNP body
namespace: cellular_component
def: "A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies." [GOC:sart, PMID:17595295]
synonym: "U body" EXACT [GOC:sart, PMID:17595295]
synonym: "U-body" EXACT [GOc:mah]
is_a: GO:0030529 ! ribonucleoprotein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0071255
name: CVT vesicle assembly
namespace: biological_process
def: "A vesicle organization process that takes place as part of the CVT pathway, and results in the formation of a double membrane-bounded cytosolic structure that sequesters precursor aminopeptidase I (prAPI)." [GOC:rb, PMID:10966461, PMID:11085977]
synonym: "CVT vesicle biosynthesis" RELATED [GOC:mah]
synonym: "CVT vesicle formation" EXACT [GOC:mah]
is_a: GO:0016050 ! vesicle organization
is_a: GO:0070925 ! organelle assembly
relationship: part_of GO:0032258 ! CVT pathway

[Term]
id: GO:0071256
name: translocon complex
namespace: cellular_component
alt_id: GO:0031206
def: "A protein complex that constitutes a specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. The complex contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins." [GOC:mah, PMID:10611978, PMID:18166647, PMID:8612571]
synonym: "Sec complex-associated translocon complex" NARROW [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044425 ! membrane part
is_a: GO:0044432 ! endoplasmic reticulum part
relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane

[Term]
id: GO:0071257
name: cellular response to electrical stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus." [GOC:mah]
synonym: "cellular response to electricity" RELATED [GOC:mah]
is_a: GO:0051602 ! response to electrical stimulus
is_a: GO:0071214 ! cellular response to abiotic stimulus

[Term]
id: GO:0071258
name: cellular response to gravity
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." [GOC:mah]
synonym: "cellular response to gravitational stimulus" EXACT [GOC:mah]
is_a: GO:0009629 ! response to gravity
is_a: GO:0071214 ! cellular response to abiotic stimulus

[Term]
id: GO:0071259
name: cellular response to magnetism
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus." [GOC:mah]
synonym: "cellular response to magnetic stimulus" EXACT [GOC:mah]
is_a: GO:0071000 ! response to magnetism
is_a: GO:0071214 ! cellular response to abiotic stimulus

[Term]
id: GO:0071260
name: cellular response to mechanical stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:mah]
synonym: "cellular mechanical stimulus response" EXACT [GOC:mah]
is_a: GO:0009612 ! response to mechanical stimulus
is_a: GO:0071214 ! cellular response to abiotic stimulus
is_a: GO:0071496 ! cellular response to external stimulus

[Term]
id: GO:0071261
name: Ssh1 translocon complex
namespace: cellular_component
def: "A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences." [GOC:mah, PMID:12134063, PMID:8612571]
synonym: "Ssh1p-Sss1p-Sbh2p complex" NARROW [GOC:mah]
is_a: GO:0071256 ! translocon complex

[Term]
id: GO:0071262
name: regulation of translational initiation in response to starvation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment." [GOC:mah]
synonym: "regulation of translational initiation in response to nutrient starvation" EXACT [GOC:vw]
is_a: GO:0009267 ! cellular response to starvation
is_a: GO:0043558 ! regulation of translational initiation in response to stress

[Term]
id: GO:0071263
name: negative regulation of translational initiation in response to starvation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate of translation initiation, as a result of deprivation of nourishment." [GOC:mah]
synonym: "down regulation of translation initiation in response to starvation" EXACT [GOC:mah]
synonym: "down-regulation of translation initiation in response to starvation" EXACT [GOC:mah]
synonym: "downregulation of translation initiation in response to starvation" EXACT [GOC:mah]
synonym: "inhibition of translation initiation in response to starvation" NARROW [GOC:mah]
synonym: "negative regulation of translational initiation in response to nutrient starvation" EXACT [GOC:vw]
is_a: GO:0032057 ! negative regulation of translational initiation in response to stress
is_a: GO:0071262 ! regulation of translational initiation in response to starvation

[Term]
id: GO:0071264
name: positive regulation of translational initiation in response to starvation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment." [GOC:mah]
synonym: "activation of translation initiation in response to starvation" NARROW [GOC:mah]
synonym: "positive regulation of translational initiation in response to nutrient starvation" EXACT [GOC:mah]
synonym: "stimulation of translation initiation in response to starvation" NARROW [GOC:mah]
synonym: "up regulation of translation initiation in response to starvation" EXACT [GOC:mah]
synonym: "up-regulation of translation initiation in response to starvation" EXACT [GOC:mah]
synonym: "upregulation of translation initiation in response to starvation" EXACT [GOC:mah]
is_a: GO:0032058 ! positive regulation of translational initiation in response to stress
is_a: GO:0071262 ! regulation of translational initiation in response to starvation

[Term]
id: GO:0071265
name: L-methionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid." [ChEBI:16643, GOC:ecd]
synonym: "L-methionine anabolism" EXACT [GOC:mah]
synonym: "L-methionine biosynthesis" EXACT [GOC:mah]
synonym: "L-methionine formation" EXACT [GOC:mah]
synonym: "L-methionine synthesis" EXACT [GOC:mah]
is_a: GO:0009086 ! methionine biosynthetic process

[Term]
id: GO:0071266
name: 'de novo' L-methionine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components." [ChEBI:16643, GOC:ecd]
synonym: "'de novo' L-methionine anabolism" EXACT [GOC:mah]
synonym: "'de novo' L-methionine biosynthesis" EXACT [GOC:mah]
synonym: "'de novo' L-methionine formation" EXACT [GOC:mah]
synonym: "'de novo' L-methionine synthesis" EXACT [GOC:mah]
is_a: GO:0071265 ! L-methionine biosynthetic process

[Term]
id: GO:0071267
name: L-methionine salvage
namespace: biological_process
def: "Any process that generates L-methionine from derivatives of it, without de novo synthesis." [ChEBI:16643, GOC:ecd]
is_a: GO:0071265 ! L-methionine biosynthetic process

[Term]
id: GO:0071268
name: homocysteine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of homocysteine, 2-amino-4-sulfanylbutanoic acid." [ChEBI:17230, GOC:ecd, GOC:mah]
synonym: "homocysteine anabolism" EXACT [GOC:mah]
synonym: "homocysteine biosynthesis" EXACT [GOC:mah]
synonym: "homocysteine formation" EXACT [GOC:mah]
synonym: "homocysteine synthesis" EXACT [GOC:mah]
is_a: GO:0000097 ! sulfur amino acid biosynthetic process
is_a: GO:0050667 ! homocysteine metabolic process

[Term]
id: GO:0071269
name: L-homocysteine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of L-homocysteine, the L-enantiomer of 2-amino-4-sulfanylbutanoic acid." [ChEBI:17588, GOC:ecd, GOC:mah]
synonym: "L-homocysteine anabolism" EXACT [GOC:mah]
synonym: "L-homocysteine biosynthesis" EXACT [GOC:mah]
synonym: "L-homocysteine formation" EXACT [GOC:mah]
synonym: "L-homocysteine synthesis" EXACT [GOC:mah]
is_a: GO:0071268 ! homocysteine biosynthetic process

[Term]
id: GO:0071270
name: 1-butanol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving 1-butanol, an alkyl primary alcohol with the formula C4H10O." [ChEBI:28885, GOC:ecd, GOC:mah]
synonym: "1-butanol metabolism" EXACT [GOC:mah]
synonym: "butan-1-ol metabolic process" EXACT [ChEBI:28885]
synonym: "butanol metabolic process" BROAD [GOC:mah]
is_a: GO:0034308 ! monohydric alcohol metabolic process

[Term]
id: GO:0071271
name: 1-butanol biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of 1-butanol, an alkyl primary alcohol with the formula C4H10O." [ChEBI:28885, GOC:ecd, GOC:mah]
synonym: "1-butanol anabolism" EXACT [GOC:mah]
synonym: "1-butanol biosynthesis" EXACT [GOC:mah]
synonym: "1-butanol formation" EXACT [GOC:mah]
synonym: "1-butanol synthesis" EXACT [GOC:mah]
synonym: "butan-1-ol biosynthetic process" EXACT [ChEBI:28885]
synonym: "butanol biosynthetic process" BROAD [GOC:mah]
is_a: GO:0034309 ! monohydric alcohol biosynthetic process
is_a: GO:0071270 ! 1-butanol metabolic process

[Term]
id: GO:0071272
name: morphine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [ChEBI:17303, GOC:mah]
subset: gosubset_prok
synonym: "morphine metabolism" EXACT [GOC:mah]
xref: Wikipedia:Morphine
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process

[Term]
id: GO:0071273
name: morphine catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [ChEBI:17303, GOC:ecd, GOC:mah]
subset: gosubset_prok
synonym: "morphine breakdown" EXACT [GOC:mah]
synonym: "morphine catabolism" EXACT [GOC:mah]
synonym: "morphine degradation" EXACT [GOC:mah]
xref: UniPathway:Q02198
is_a: GO:0071272 ! morphine metabolic process
is_a: GO:0071274 ! isoquinoline alkaloid catabolic process

[Term]
id: GO:0071274
name: isoquinoline alkaloid catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html]
subset: gosubset_prok
synonym: "ipecac alkaloid catabolism" RELATED [GOC:mah]
synonym: "isoquinoline alkaloid breakdown" EXACT [GOC:mah]
synonym: "isoquinoline alkaloid catabolism" EXACT [GOC:mah]
synonym: "isoquinoline alkaloid degradation" EXACT [GOC:mah]
is_a: GO:0009822 ! alkaloid catabolic process
is_a: GO:0033076 ! isoquinoline alkaloid metabolic process

[Term]
id: GO:0071275
name: cellular response to aluminum ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus." [GOC:mah]
synonym: "cellular response to aluminium ion" EXACT [GOC:mah]
synonym: "cellular response to aluminum" EXACT [GOC:mah]
is_a: GO:0010044 ! response to aluminum ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071276
name: cellular response to cadmium ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to cadmium" EXACT [GOC:mah]
is_a: GO:0046686 ! response to cadmium ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071277
name: cellular response to calcium ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah]
synonym: "cellular response to Ca2+ ion" EXACT [GOC:mah]
is_a: GO:0051592 ! response to calcium ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071278
name: cellular response to cesium ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus." [GOC:mah]
synonym: "cellular response to cesium" EXACT [GOC:mah]
is_a: GO:0010164 ! response to cesium ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071279
name: cellular response to cobalt ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus." [GOC:mah]
is_a: GO:0032025 ! response to cobalt ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071280
name: cellular response to copper ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to copper" EXACT [GOC:mah]
is_a: GO:0046688 ! response to copper ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071281
name: cellular response to iron ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:mah]
synonym: "cellular response to iron" EXACT [GOC:mah]
is_a: GO:0010039 ! response to iron ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071282
name: cellular response to iron(II) ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus." [GOC:mah]
synonym: "cellular response to iron(II)" EXACT [GOC:mah]
is_a: GO:0010040 ! response to iron(II) ion
is_a: GO:0071281 ! cellular response to iron ion

[Term]
id: GO:0071283
name: cellular response to iron(III) ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus." [GOC:mah]
synonym: "cellular response to iron(III)" EXACT [GOC:mah]
is_a: GO:0010041 ! response to iron(III) ion
is_a: GO:0071281 ! cellular response to iron ion

[Term]
id: GO:0071284
name: cellular response to lead ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus." [GOC:mah]
is_a: GO:0010288 ! response to lead ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071285
name: cellular response to lithium ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:mah]
is_a: GO:0010226 ! response to lithium ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071286
name: cellular response to magnesium ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus." [GOC:mah]
is_a: GO:0032026 ! response to magnesium ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071287
name: cellular response to manganese ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:mah]
synonym: "cellular response to manganese" EXACT [GOC:mah]
is_a: GO:0010042 ! response to manganese ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071288
name: cellular response to mercury ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to mercuric ion" EXACT [GOC:mah]
synonym: "cellular response to mercury" EXACT [GOC:mah]
is_a: GO:0046689 ! response to mercury ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071289
name: cellular response to nickel ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel ion stimulus." [GOC:mah]
synonym: "cellular response to nickel" EXACT [GOC:mah]
is_a: GO:0010045 ! response to nickel ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071290
name: cellular response to platinum ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus." [GOC:mah]
synonym: "cellular response to platinum" EXACT [GOc:mah]
is_a: GO:0070541 ! response to platinum ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071291
name: cellular response to selenium ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion." [GOC:mah]
is_a: GO:0010269 ! response to selenium ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071292
name: cellular response to silver ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus." [GOC:mah]
is_a: GO:0010272 ! response to silver ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071293
name: cellular response to tellurium ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to tellurium" EXACT [GOC:mah]
is_a: GO:0046690 ! response to tellurium ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071294
name: cellular response to zinc ion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:mah]
synonym: "cellular response to zinc" EXACT [GOC:mah]
is_a: GO:0010043 ! response to zinc ion
is_a: GO:0071248 ! cellular response to metal ion

[Term]
id: GO:0071295
name: cellular response to vitamin
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus." [GOC:mah]
is_a: GO:0031670 ! cellular response to nutrient
is_a: GO:0033273 ! response to vitamin

[Term]
id: GO:0071296
name: cellular response to biotin
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus." [GOC:mah]
synonym: "cellular response to Bios IIB" EXACT [GOC:sl]
synonym: "cellular response to coenzyme R" EXACT [GOC:sl]
synonym: "cellular response to vitamin B7" EXACT [GOC:sl]
synonym: "cellular response to vitamin H" EXACT [GOC:sl]
is_a: GO:0070781 ! response to biotin
is_a: GO:0071295 ! cellular response to vitamin

[Term]
id: GO:0071297
name: cellular response to cobalamin
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus." [GOC:mah]
synonym: "cellular response to vitamin B12" EXACT [GOC:mah]
is_a: GO:0033590 ! response to cobalamin
is_a: GO:0071295 ! cellular response to vitamin

[Term]
id: GO:0071298
name: cellular response to L-ascorbic acid
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus." [GOC:mah]
synonym: "cellular response to ascorbic acid" BROAD [GOC:mah]
synonym: "cellular response to L-ascorbate" EXACT [GOC:mah]
synonym: "cellular response to vitamin C" EXACT [GOC:mah]
is_a: GO:0033591 ! response to L-ascorbic acid
is_a: GO:0071295 ! cellular response to vitamin

[Term]
id: GO:0071299
name: cellular response to vitamin A
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus." [GOC:mah]
synonym: "cellular response to retinol" NARROW [GOC:mah]
is_a: GO:0033189 ! response to vitamin A
is_a: GO:0071295 ! cellular response to vitamin

[Term]
id: GO:0071300
name: cellular response to retinoic acid
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:mah]
synonym: "cellular response to vitamin A acid" EXACT [GOC:mah]
is_a: GO:0032526 ! response to retinoic acid
is_a: GO:0071299 ! cellular response to vitamin A

[Term]
id: GO:0071301
name: cellular response to vitamin B1
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:mah]
synonym: "cellular response to thiamin" EXACT [GOC:mah]
synonym: "cellular response to thiamine" EXACT [GOC:mah]
is_a: GO:0010266 ! response to vitamin B1
is_a: GO:0071295 ! cellular response to vitamin

[Term]
id: GO:0071302
name: cellular response to vitamin B2
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus." [GOC:mah]
synonym: "cellular response to riboflavin" EXACT [GOC:mah]
is_a: GO:0033274 ! response to vitamin B2
is_a: GO:0071295 ! cellular response to vitamin

[Term]
id: GO:0071303
name: cellular response to vitamin B3
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus." [GOC:mah]
synonym: "cellular response to niacin" NARROW [GOC:mah]
synonym: "cellular response to nicotinamide" NARROW [GOC:mah]
is_a: GO:0033552 ! response to vitamin B3
is_a: GO:0071295 ! cellular response to vitamin

[Term]
id: GO:0071304
name: cellular response to vitamin B6
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah]
is_a: GO:0034516 ! response to vitamin B6
is_a: GO:0071295 ! cellular response to vitamin

[Term]
id: GO:0071305
name: cellular response to vitamin D
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus." [GOC:mah]
synonym: "cellular response to calciferol" EXACT [GOC:mah]
synonym: "cellular response to cholecalciferol" NARROW [GOC:mah]
synonym: "cellular response to ergocalciferol" NARROW [GOC:mah]
is_a: GO:0033280 ! response to vitamin D
is_a: GO:0071295 ! cellular response to vitamin

[Term]
id: GO:0071306
name: cellular response to vitamin E
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus." [GOC:mah]
synonym: "cellular response to DL-alpha-tocopherol acetate" NARROW [GOC:mah]
synonym: "cellular response to DL-alpha-tocopheryl acetate" NARROW [GOC:mah]
synonym: "cellular response to O-Acetyl-alpha-tocopherol" NARROW [GOC:mah]
is_a: GO:0033197 ! response to vitamin E
is_a: GO:0071295 ! cellular response to vitamin

[Term]
id: GO:0071307
name: cellular response to vitamin K
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus." [GOC:mah]
is_a: GO:0032571 ! response to vitamin K
is_a: GO:0071295 ! cellular response to vitamin

[Term]
id: GO:0071308
name: cellular response to menaquinone
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus." [GOC:mah]
synonym: "cellular response to menatetrenone" EXACT [GOC:mah]
synonym: "cellular response to vitamin K2" EXACT [GOC:mah]
is_a: GO:0032572 ! response to menaquinone
is_a: GO:0071307 ! cellular response to vitamin K

[Term]
id: GO:0071309
name: cellular response to phylloquinone
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:mah]
synonym: "cellular response to vitamin K1" EXACT [GOC:mah]
is_a: GO:0032573 ! response to phylloquinone
is_a: GO:0071307 ! cellular response to vitamin K

[Term]
id: GO:0071310
name: cellular response to organic substance
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:mah]
subset: gosubset_prok
is_a: GO:0010033 ! response to organic substance
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071311
name: cellular response to acetate
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:mah]
subset: gosubset_prok
is_a: GO:0010034 ! response to acetate
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071312
name: cellular response to alkaloid
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:mah]
is_a: GO:0043279 ! response to alkaloid
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071313
name: cellular response to caffeine
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [GOC:mah]
is_a: GO:0031000 ! response to caffeine
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071415 ! cellular response to purine

[Term]
id: GO:0071314
name: cellular response to cocaine
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [GOC:mah]
is_a: GO:0042220 ! response to cocaine
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071416 ! cellular response to tropane

[Term]
id: GO:0071315
name: cellular response to morphine
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [GOC:mah]
is_a: GO:0043278 ! response to morphine
is_a: GO:0071317 ! cellular response to isoquinoline alkaloid

[Term]
id: GO:0071316
name: cellular response to nicotine
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [GOC:mah]
is_a: GO:0035094 ! response to nicotine
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071407 ! cellular response to organic cyclic substance

[Term]
id: GO:0071317
name: cellular response to isoquinoline alkaloid
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids." [GOC:mah]
is_a: GO:0014072 ! response to isoquinoline alkaloid
is_a: GO:0071312 ! cellular response to alkaloid
is_a: GO:0071407 ! cellular response to organic cyclic substance

[Term]
id: GO:0071318
name: cellular response to ATP
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:mah]
synonym: "cellular response to adenosine 5'-triphosphate" EXACT [GOC:mah]
synonym: "cellular response to adenosine triphosphate" EXACT [GOC:mah]
is_a: GO:0033198 ! response to ATP
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071319
name: cellular response to benzoic acid
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [GOC:mah]
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0080021 ! response to benzoic acid stimulus

[Term]
id: GO:0071320
name: cellular response to cAMP
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:mah]
synonym: "cellular response to 3',5' cAMP" EXACT [GOC:mah]
synonym: "cellular response to 3',5'-cAMP" EXACT [GOC:mah]
synonym: "cellular response to adenosine 3',5'-cyclophosphate" EXACT [GOC:mah]
synonym: "cellular response to cyclic AMP" EXACT [GOC:mah]
is_a: GO:0051591 ! response to cAMP
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071321
name: cellular response to cGMP
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus." [GOC:mah]
synonym: "cellular response to 3',5' cGMP" EXACT [GOC:mah]
synonym: "cellular response to 3',5'-cGMP" EXACT [GOC:mah]
synonym: "cellular response to cyclic GMP" EXACT [GOC:mah]
synonym: "cellular response to guanosine 3',5'-cyclophosphate" EXACT [GOC:mah]
is_a: GO:0070305 ! response to cGMP
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071322
name: cellular response to carbohydrate stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:mah]
is_a: GO:0009743 ! response to carbohydrate stimulus
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071323
name: cellular response to chitin
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:mah]
is_a: GO:0010200 ! response to chitin
is_a: GO:0071322 ! cellular response to carbohydrate stimulus

[Term]
id: GO:0071324
name: cellular response to disaccharide stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus." [GOC:mah]
is_a: GO:0034285 ! response to disaccharide stimulus
is_a: GO:0071322 ! cellular response to carbohydrate stimulus

[Term]
id: GO:0071325
name: cellular response to mannitol stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:mah]
is_a: GO:0010555 ! response to mannitol stimulus
is_a: GO:0071322 ! cellular response to carbohydrate stimulus

[Term]
id: GO:0071326
name: cellular response to monosaccharide stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah]
is_a: GO:0034284 ! response to monosaccharide stimulus
is_a: GO:0071322 ! cellular response to carbohydrate stimulus

[Term]
id: GO:0071327
name: cellular response to trehalose stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [GOC:mah]
is_a: GO:0010353 ! response to trehalose stimulus
is_a: GO:0071324 ! cellular response to disaccharide stimulus

[Term]
id: GO:0071328
name: cellular response to maltose stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus." [GOC:mah]
is_a: GO:0034286 ! response to maltose stimulus
is_a: GO:0071324 ! cellular response to disaccharide stimulus

[Term]
id: GO:0071329
name: cellular response to sucrose stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:mah]
is_a: GO:0009744 ! response to sucrose stimulus
is_a: GO:0071324 ! cellular response to disaccharide stimulus

[Term]
id: GO:0071330
name: cellular response to trehalose-6-phosphate stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus." [GOC:mah]
is_a: GO:0071324 ! cellular response to disaccharide stimulus
is_a: GO:0080094 ! response to trehalose-6-phosphate stimulus

[Term]
id: GO:0071331
name: cellular response to hexose stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:mah]
is_a: GO:0009746 ! response to hexose stimulus
is_a: GO:0071326 ! cellular response to monosaccharide stimulus

[Term]
id: GO:0071332
name: cellular response to fructose stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:mah]
is_a: GO:0009750 ! response to fructose stimulus
is_a: GO:0071331 ! cellular response to hexose stimulus

[Term]
id: GO:0071333
name: cellular response to glucose stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah]
is_a: GO:0009749 ! response to glucose stimulus
is_a: GO:0071331 ! cellular response to hexose stimulus

[Term]
id: GO:0071334
name: cellular response to rhamnose stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus." [GOC:mah]
synonym: "cellular response to L-rhamnose stimulus" NARROW [GOC:mah]
is_a: GO:0032149 ! response to rhamnose stimulus
is_a: GO:0071331 ! cellular response to hexose stimulus

[Term]
id: GO:0071335
name: hair follicle cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of hair follicle cells, resulting in the expansion of a cell population." [GOC:rph, PMID:16086254]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0071336
name: regulation of hair follicle cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of hair follicle cell proliferation." [GOC:mah]
is_a: GO:0042127 ! regulation of cell proliferation
relationship: regulates GO:0071335 ! hair follicle cell proliferation

[Term]
id: GO:0071337
name: negative regulation of hair follicle cell proliferation
namespace: biological_process
def: "Any process that stops, prevents or reduces the rate or extent of hair follicle cell proliferation." [GOC:mah]
synonym: "down regulation of hair follicle cell proliferation" EXACT [GOC:mah]
synonym: "down-regulation of hair follicle cell proliferation" EXACT [GOC:mah]
synonym: "downregulation of hair follicle cell proliferation" EXACT [GOc:mah]
synonym: "inhibition of hair follicle cell proliferation" NARROW [GOC:mah]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0071336 ! regulation of hair follicle cell proliferation
relationship: negatively_regulates GO:0071335 ! hair follicle cell proliferation

[Term]
id: GO:0071338
name: positive regulation of hair follicle cell proliferation
namespace: biological_process
def: "Any process that activates or increases the rate or extent of hair follicle cell proliferation." [GOC:mah]
synonym: "activation of hair follicle cell proliferation" NARROW [GOC:mah]
synonym: "stimulation of hair follicle cell proliferation" NARROW [GOC:mah]
synonym: "up regulation of hair follicle cell proliferation" EXACT [GOC:mah]
synonym: "up-regulation of hair follicle cell proliferation" EXACT [GOC:mah]
synonym: "upregulation of hair follicle cell proliferation" EXACT [GOC:mah]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0071336 ! regulation of hair follicle cell proliferation
relationship: positively_regulates GO:0071335 ! hair follicle cell proliferation

[Term]
id: GO:0071339
name: MLL1 complex
namespace: cellular_component
def: "A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5." [GOC:sp, PMID:15960975]
is_a: GO:0035097 ! histone methyltransferase complex

[Term]
id: GO:0071340
name: skeletal muscle nicotinic acetylcholine receptor clustering
namespace: biological_process
def: "The accumulation of acetylcholine receptors (AChRs) in a narrow, central region of muscle fibers, in apposition to nerve terminals." [GOC:dsf, PMID:19285469]
synonym: "skeletal muscle AChR clustering" EXACT [GOC:mah]
is_a: GO:0001941 ! postsynaptic membrane organization
is_a: GO:0043113 ! receptor clustering
relationship: part_of GO:0007528 ! neuromuscular junction development

[Term]
id: GO:0071341
name: medial cortical node
namespace: cellular_component
def: "A protein complex that contains the mid1, cdr2, wee1, klp8, and blt1 proteins, and is involved in contractile ring localization. Medial cortical node complexes appear as cortical dots in the middle of the cell during interphase, and function to recruit other ring components in early mitosis." [GOC:mah, GOC:vw, PMID:19474789, PMID:19959363]
synonym: "mid1p medial cortical dot" EXACT [GOC:vw]
synonym: "midsome" EXACT [GOC:vw, PMID:19959363]
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0031097 ! medial cortex

[Term]
id: GO:0071342
name: regulation of establishment of contractile ring localization involved in cytokinesis during cell cycle
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the process by which a contractile ring is assembled in a specific location that contributes to cytokinesis during cell cycle." [GOC:dph, GOC:mah, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0032954 ! regulation of cytokinetic process
is_a: GO:0032956 ! regulation of actin cytoskeleton organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0032188 ! establishment of contractile ring localization involved in cytokinesis during cell cycle

[Term]
id: GO:0071343
name: negative regulation of establishment of contractile ring localization involved in cytokinesis during cell cycle
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the process by which a contractile ring is assembled in a specific location." [GOC:mah]
is_a: GO:0051494 ! negative regulation of cytoskeleton organization
is_a: GO:0071342 ! regulation of establishment of contractile ring localization involved in cytokinesis during cell cycle
relationship: negatively_regulates GO:0032188 ! establishment of contractile ring localization involved in cytokinesis during cell cycle

[Term]
id: GO:0071344
name: diphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving diphosphate, the anion or salt of diphosphoric acid." [ChEBI:35782, GOC:pde]
subset: gosubset_prok
synonym: "pyrophosphate metabolism" EXACT [GOC:mah]
is_a: GO:0006796 ! phosphate metabolic process

[Term]
id: GO:0071345
name: cellular response to cytokine stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah]
is_a: GO:0034097 ! response to cytokine stimulus
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071346
name: cellular response to interferon-gamma
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon." [GOC:mah]
synonym: "cellular response to gamma-interferon" RELATED [GOC:mah]
synonym: "cellular response to immune interferon" EXACT [GOC:mah]
synonym: "cellular response to type II IFN" EXACT [GOC:mah]
synonym: "cellular response to type II interferon" EXACT [GOC:mah]
is_a: GO:0034341 ! response to interferon-gamma
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071347
name: cellular response to interleukin-1
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus." [GOC:mah]
synonym: "cellular response to IL-1" EXACT [GOC:mah]
is_a: GO:0070555 ! response to interleukin-1
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071348
name: cellular response to interleukin-11
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus." [GOC:mah]
synonym: "cellular response to IL-11" EXACT [GOC:mah]
is_a: GO:0071105 ! response to interleukin-11
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071349
name: cellular response to interleukin-12
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus." [GOC:mah]
synonym: "cellular response to IL-12" EXACT [GOC:mah]
is_a: GO:0070671 ! response to interleukin-12
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071350
name: cellular response to interleukin-15
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus." [GOC:mah]
synonym: "cellular response to IL-15" EXACT [GOC:mah]
is_a: GO:0070672 ! response to interleukin-15
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071351
name: cellular response to interleukin-18
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus." [GOC:mah]
synonym: "cellular response to IL-18" EXACT [GOC:mah]
is_a: GO:0070673 ! response to interleukin-18
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071352
name: cellular response to interleukin-2
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus." [GOC:mah]
synonym: "cellular response to IL-2" EXACT [GOC:mah]
is_a: GO:0070669 ! response to interleukin-2
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071353
name: cellular response to interleukin-4
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus." [GOC:mah]
synonym: "cellular response to IL-4" EXACT [GOC:mah]
is_a: GO:0070670 ! response to interleukin-4
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071354
name: cellular response to interleukin-6
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah]
synonym: "cellular response to IL-6" EXACT [GOC:mah]
is_a: GO:0070741 ! response to interleukin-6
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071355
name: cellular response to interleukin-9
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus." [GOC:mah]
synonym: "cellular response to IL-9" EXACT [GOC:mah]
is_a: GO:0071104 ! response to interleukin-9
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071356
name: cellular response to tumor necrosis factor
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah]
synonym: "cellular response to TNF" EXACT [GOC:mah]
is_a: GO:0034612 ! response to tumor necrosis factor
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071357
name: cellular response to type I interferon
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:mah]
synonym: "cellular response to type I IFN" EXACT [GOC:mah]
is_a: GO:0034340 ! response to type I interferon
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071358
name: cellular response to type III interferon
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Type III interferons are members of the interferon-lambda gene family." [GOC:mah]
synonym: "cellular response to interferon-lambda" EXACT [GOC:mah]
synonym: "cellular response to type III IFN" EXACT [GOC:mah]
is_a: GO:0034342 ! response to type III interferon
is_a: GO:0071345 ! cellular response to cytokine stimulus

[Term]
id: GO:0071359
name: cellular response to dsRNA
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus." [GOC:mah]
synonym: "cellular response to double-stranded RNA" EXACT [GOC:mah]
is_a: GO:0043331 ! response to dsRNA
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071360
name: cellular response to exogenous dsRNA
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:mah]
synonym: "cellular response to exogenous double-stranded RNA" EXACT [GOC:mah]
synonym: "cellular response to viral dsRNA" NARROW [GOC:mah]
is_a: GO:0043330 ! response to exogenous dsRNA
is_a: GO:0071359 ! cellular response to dsRNA

[Term]
id: GO:0071361
name: cellular response to ethanol
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:mah]
is_a: GO:0045471 ! response to ethanol
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071362
name: cellular response to ether
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:mah]
is_a: GO:0045472 ! response to ether

[Term]
id: GO:0071363
name: cellular response to growth factor stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah]
is_a: GO:0070848 ! response to growth factor stimulus
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071364
name: cellular response to epidermal growth factor stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:mah]
synonym: "cellular response to EGF stimulus" EXACT [GOC:mah]
is_a: GO:0070849 ! response to epidermal growth factor stimulus
is_a: GO:0071363 ! cellular response to growth factor stimulus
is_a: GO:0071495 ! cellular response to endogenous stimulus

[Term]
id: GO:0071365
name: cellular response to auxin stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus." [GOC:mah]
is_a: GO:0009733 ! response to auxin stimulus
is_a: GO:0032870 ! cellular response to hormone stimulus

[Term]
id: GO:0071366
name: cellular response to indolebutyric acid stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus." [GOC:mah]
synonym: "cellular response to IBA stimulus" EXACT [GOC:mah]
synonym: "cellular response to indole-3-butyric acid stimulus" NARROW [GOC:mah]
is_a: GO:0071365 ! cellular response to auxin stimulus
is_a: GO:0080026 ! response to indolebutyric acid stimulus

[Term]
id: GO:0071367
name: cellular response to brassinosteroid stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus." [GOC:mah]
is_a: GO:0009741 ! response to brassinosteroid stimulus
is_a: GO:0032870 ! cellular response to hormone stimulus

[Term]
id: GO:0071368
name: cellular response to cytokinin stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus." [GOC:mah]
is_a: GO:0009735 ! response to cytokinin stimulus
is_a: GO:0032870 ! cellular response to hormone stimulus

[Term]
id: GO:0071369
name: cellular response to ethylene stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus." [GOC:mah]
synonym: "cellular response to ethene stimulus" EXACT [GOC:mah]
is_a: GO:0009723 ! response to ethylene stimulus
is_a: GO:0032870 ! cellular response to hormone stimulus

[Term]
id: GO:0071370
name: cellular response to gibberellin stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:mah]
synonym: "cellular response to gibberellic acid stimulus" NARROW [GOC:mah]
is_a: GO:0009739 ! response to gibberellin stimulus
is_a: GO:0032870 ! cellular response to hormone stimulus

[Term]
id: GO:0071371
name: cellular response to gonadotropin stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus." [GOC:mah]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0034698 ! response to gonadotropin stimulus

[Term]
id: GO:0071372
name: cellular response to follicle-stimulating hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus." [GOC:mah]
is_a: GO:0032354 ! response to follicle-stimulating hormone stimulus
is_a: GO:0071371 ! cellular response to gonadotropin stimulus

[Term]
id: GO:0071373
name: cellular response to luteinizing hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus." [GOC:mah]
is_a: GO:0034699 ! response to luteinizing hormone stimulus
is_a: GO:0071371 ! cellular response to gonadotropin stimulus

[Term]
id: GO:0071374
name: cellular response to parathyroid hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus." [GOC:mah]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0071107 ! response to parathyroid hormone stimulus

[Term]
id: GO:0071375
name: cellular response to peptide hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah]
synonym: "cellular response to polypeptide hormone stimulus" EXACT [GOC:mah]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0043434 ! response to peptide hormone stimulus

[Term]
id: GO:0071376
name: cellular response to corticotropin-releasing hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response." [GOC:mah]
synonym: "cellular response to corticoliberin stimulus" EXACT [GOC:mah]
synonym: "cellular response to corticotropin-releasing factor stimulus" EXACT [GOC:mah]
synonym: "cellular response to CRF stimulus" EXACT [GOC:mah]
synonym: "cellular response to CRH stimulus" EXACT [GOC:mah]
is_a: GO:0043435 ! response to corticotropin-releasing hormone stimulus
is_a: GO:0071375 ! cellular response to peptide hormone stimulus

[Term]
id: GO:0071377
name: cellular response to glucagon stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:mah]
is_a: GO:0033762 ! response to glucagon stimulus
is_a: GO:0071375 ! cellular response to peptide hormone stimulus

[Term]
id: GO:0071378
name: cellular response to growth hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth." [GOC:mah]
is_a: GO:0060416 ! response to growth hormone stimulus
is_a: GO:0071375 ! cellular response to peptide hormone stimulus

[Term]
id: GO:0071379
name: cellular response to prostaglandin stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus." [GOC:mah]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0034694 ! response to prostaglandin stimulus
is_a: GO:0071396 ! cellular response to lipid

[Term]
id: GO:0071380
name: cellular response to prostaglandin E stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus." [GOC:mah]
is_a: GO:0034695 ! response to prostaglandin E stimulus
is_a: GO:0071379 ! cellular response to prostaglandin stimulus

[Term]
id: GO:0071381
name: cellular response to prostaglandin F stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus." [GOC:mah]
is_a: GO:0034696 ! response to prostaglandin F stimulus
is_a: GO:0071379 ! cellular response to prostaglandin stimulus

[Term]
id: GO:0071382
name: cellular response to prostaglandin I stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus." [GOC:mah]
is_a: GO:0034697 ! response to prostaglandin I stimulus
is_a: GO:0071379 ! cellular response to prostaglandin stimulus

[Term]
id: GO:0071383
name: cellular response to steroid hormone stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah]
is_a: GO:0032870 ! cellular response to hormone stimulus
is_a: GO:0048545 ! response to steroid hormone stimulus

[Term]
id: GO:0071384
name: cellular response to corticosteroid stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah]
is_a: GO:0031960 ! response to corticosteroid stimulus
is_a: GO:0071383 ! cellular response to steroid hormone stimulus

[Term]
id: GO:0071385
name: cellular response to glucocorticoid stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:mah]
is_a: GO:0051384 ! response to glucocorticoid stimulus
is_a: GO:0071384 ! cellular response to corticosteroid stimulus

[Term]
id: GO:0071386
name: cellular response to corticosterone stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses." [GOC:mah]
is_a: GO:0051412 ! response to corticosterone stimulus
is_a: GO:0071385 ! cellular response to glucocorticoid stimulus
is_a: GO:0071389 ! cellular response to mineralocorticoid stimulus

[Term]
id: GO:0071387
name: cellular response to cortisol stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [GOC:mah]
synonym: "cellular response to hydrocortisone stimulus" EXACT [GOC:mah]
is_a: GO:0051414 ! response to cortisol stimulus
is_a: GO:0071385 ! cellular response to glucocorticoid stimulus

[Term]
id: GO:0071388
name: cellular response to cortisone stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues." [GOC:mah]
is_a: GO:0051413 ! response to cortisone stimulus
is_a: GO:0071385 ! cellular response to glucocorticoid stimulus

[Term]
id: GO:0071389
name: cellular response to mineralocorticoid stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance." [GOC:mah]
is_a: GO:0051385 ! response to mineralocorticoid stimulus
is_a: GO:0071384 ! cellular response to corticosteroid stimulus

[Term]
id: GO:0071390
name: cellular response to ecdysone
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:mah]
is_a: GO:0035075 ! response to ecdysone
is_a: GO:0071383 ! cellular response to steroid hormone stimulus

[Term]
id: GO:0071391
name: cellular response to estrogen stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:mah]
synonym: "cellular response to oestrogen stimulus" EXACT [GOC:mah]
is_a: GO:0043627 ! response to estrogen stimulus
is_a: GO:0071383 ! cellular response to steroid hormone stimulus

[Term]
id: GO:0071392
name: cellular response to estradiol stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah]
synonym: "cellular response to E2 stimulus" EXACT [GOC:mah]
is_a: GO:0032355 ! response to estradiol stimulus
is_a: GO:0071391 ! cellular response to estrogen stimulus

[Term]
id: GO:0071393
name: cellular response to progesterone stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:mah]
is_a: GO:0032570 ! response to progesterone stimulus
is_a: GO:0071383 ! cellular response to steroid hormone stimulus

[Term]
id: GO:0071394
name: cellular response to testosterone stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:mah]
is_a: GO:0033574 ! response to testosterone stimulus
is_a: GO:0071383 ! cellular response to steroid hormone stimulus

[Term]
id: GO:0071395
name: cellular response to jasmonic acid stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:mah]
is_a: GO:0009753 ! response to jasmonic acid stimulus
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0071495 ! cellular response to endogenous stimulus

[Term]
id: GO:0071396
name: cellular response to lipid
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah]
is_a: GO:0033993 ! response to lipid
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071397
name: cellular response to cholesterol
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus." [GOC:mah]
is_a: GO:0070723 ! response to cholesterol
is_a: GO:0071396 ! cellular response to lipid

[Term]
id: GO:0071398
name: cellular response to fatty acid
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [GOC:mah]
is_a: GO:0070542 ! response to fatty acid
is_a: GO:0071396 ! cellular response to lipid

[Term]
id: GO:0071399
name: cellular response to linoleic acid
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus." [GOC:mah]
synonym: "cellular response to linoleate" EXACT [GOC:mah]
is_a: GO:0070543 ! response to linoleic acid
is_a: GO:0071398 ! cellular response to fatty acid

[Term]
id: GO:0071400
name: cellular response to oleic acid
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus." [GOC:mah]
synonym: "cellular response to oleate" EXACT [GOC:mah]
is_a: GO:0034201 ! response to oleic acid
is_a: GO:0071398 ! cellular response to fatty acid

[Term]
id: GO:0071401
name: cellular response to triglyceride
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus." [GOC:mah]
synonym: "cellular response to triacylglyceride" EXACT [GOC:mah]
synonym: "cellular response to triacylglycerol" EXACT [GOC:mah]
is_a: GO:0034014 ! response to triglyceride
is_a: GO:0071396 ! cellular response to lipid

[Term]
id: GO:0071402
name: cellular response to lipoprotein stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein stimulus." [GOC:mah]
is_a: GO:0055094 ! response to lipoprotein stimulus
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0071495 ! cellular response to endogenous stimulus

[Term]
id: GO:0071403
name: cellular response to high density lipoprotein stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein stimulus." [GOC:mah]
is_a: GO:0055099 ! response to high density lipoprotein stimulus
is_a: GO:0071402 ! cellular response to lipoprotein stimulus

[Term]
id: GO:0071404
name: cellular response to low-density lipoprotein stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein stimulus." [GOC:mah]
is_a: GO:0055098 ! response to low-density lipoprotein stimulus
is_a: GO:0071402 ! cellular response to lipoprotein stimulus

[Term]
id: GO:0071405
name: cellular response to methanol
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:mah]
is_a: GO:0033986 ! response to methanol
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071406
name: cellular response to methylmercury
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus." [GOC:mah]
synonym: "cellular response to CH3-Hg+" EXACT [GOC:mah]
synonym: "cellular response to MeHg+" EXACT [GOC:mah]
is_a: GO:0051597 ! response to methylmercury
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071407
name: cellular response to organic cyclic substance
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic substance stimulus." [GOC:mah]
is_a: GO:0014070 ! response to organic cyclic substance
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071408
name: cellular response to cycloalkane
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n." [GOC:mah]
is_a: GO:0014071 ! response to cycloalkane
is_a: GO:0071407 ! cellular response to organic cyclic substance

[Term]
id: GO:0071409
name: cellular response to cycloheximide
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes." [GOC:mah]
synonym: "cellular response to actidione" EXACT [GOC:mah]
is_a: GO:0046898 ! response to cycloheximide
is_a: GO:0071408 ! cellular response to cycloalkane

[Term]
id: GO:0071410
name: cellular response to cyclopentenone
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid." [GOC:mah]
is_a: GO:0010583 ! response to cyclopentenone
is_a: GO:0071407 ! cellular response to organic cyclic substance

[Term]
id: GO:0071411
name: cellular response to fluoxetine
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor." [GOC:mah]
is_a: GO:0014076 ! response to fluoxetine
is_a: GO:0071407 ! cellular response to organic cyclic substance

[Term]
id: GO:0071412
name: cellular response to genistein
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [GOC:mah]
is_a: GO:0033595 ! response to genistein
is_a: GO:0071407 ! cellular response to organic cyclic substance

[Term]
id: GO:0071413
name: cellular response to hydroxyisoflavone
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus." [GOC:mah]
is_a: GO:0033594 ! response to hydroxyisoflavone
is_a: GO:0071407 ! cellular response to organic cyclic substance

[Term]
id: GO:0071414
name: cellular response to methotrexate
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [GOC:mah]
is_a: GO:0031427 ! response to methotrexate
is_a: GO:0071407 ! cellular response to organic cyclic substance

[Term]
id: GO:0071415
name: cellular response to purine
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine stimulus. Aside from DNA and RNA, purines are biochemically significant components in a number of other important biomolecules, such as ATP, GTP, cyclic AMP, NADH, and coenzyme A." [GOC:mah]
is_a: GO:0014074 ! response to purine
is_a: GO:0071407 ! cellular response to organic cyclic substance

[Term]
id: GO:0071416
name: cellular response to tropane
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine." [GOC:mah]
is_a: GO:0014073 ! response to tropane
is_a: GO:0071407 ! cellular response to organic cyclic substance

[Term]
id: GO:0071417
name: cellular response to organic nitrogen
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic nitrogen stimulus. An organic nitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [GOC:mah]
synonym: "cellular response to organonitrogen compound" EXACT [GOC:mah]
is_a: GO:0010243 ! response to organic nitrogen
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0071495 ! cellular response to endogenous stimulus

[Term]
id: GO:0071418
name: cellular response to amine stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:mah]
is_a: GO:0014075 ! response to amine stimulus
is_a: GO:0071417 ! cellular response to organic nitrogen

[Term]
id: GO:0071419
name: cellular response to amphetamine
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [GOC:mah]
is_a: GO:0001975 ! response to amphetamine
is_a: GO:0071418 ! cellular response to amine stimulus

[Term]
id: GO:0071420
name: cellular response to histamine
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter." [GOC:mah]
synonym: "cellular response to histamine stimulus" EXACT [GOC:mah]
is_a: GO:0034776 ! response to histamine
is_a: GO:0071418 ! cellular response to amine stimulus

[Term]
id: GO:0071421
name: manganese ion transmembrane transport
namespace: biological_process
def: "A process whereby a manganese ion is transported from one side of a membrane to the other." [GOC:mah]
synonym: "transmembrane manganese transport" EXACT [GOC:mah]
is_a: GO:0006828 ! manganese ion transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0071422
name: succinate transmembrane transport
namespace: biological_process
def: "A process whereby a succinate ion is transported from one side of a membrane to the other." [GOC:mah]
synonym: "transmembrane succinate transport" EXACT [GOC:mah]
is_a: GO:0015744 ! succinate transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0071423
name: malate transmembrane transport
namespace: biological_process
def: "A process whereby a malate ion is transported from one side of a membrane to the other." [GOC:mah]
synonym: "transmembrane malate transport" EXACT [GOC:mah]
is_a: GO:0015743 ! malate transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0071424
name: rRNA (cytosine-N4-)-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine." [GOC:imk, PMID:19965768]
subset: gosubset_prok
xref: EC:2.1.1.-
is_a: GO:0008170 ! N-methyltransferase activity
is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity

[Term]
id: GO:0071425
name: hemopoietic stem cell proliferation
namespace: biological_process
def: "The expansion of a hemopoietic stem cell population by cell division. A hemopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop." [CL:0000037, GOC:add, GOC:mah]
synonym: "hematopoietic stem cell proliferation" EXACT [GOC:mah]
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0030097 ! hemopoiesis

[Term]
id: GO:0071426
name: ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex from the nucleus to the cytoplasm." [GOC:mah]
synonym: "ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "RNP export from nucleus" EXACT [GOC:mah]
is_a: GO:0071166 ! ribonucleoprotein complex localization

[Term]
id: GO:0071427
name: mRNA-containing ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex that contains messenger RNA from the nucleus to the cytoplasm." [GOC:mah]
synonym: "mRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "mRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "mRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "mRNA-containing RNP export from nucleus" EXACT [GOC:mah]
is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus

[Term]
id: GO:0071428
name: rRNA-containing ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex that contains ribosomal RNA from the nucleus to the cytoplasm." [GOC:mah]
synonym: "rRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "rRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "rRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "rRNA-containing RNP export from nucleus" EXACT [GOC:mah]
is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus

[Term]
id: GO:0071429
name: snRNA-containing ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex that contains small nuclear RNA from the nucleus to the cytoplasm." [GOC:mah]
synonym: "snRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "snRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "snRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "snRNA-containing RNP export from nucleus" EXACT [GOC:mah]
is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus

[Term]
id: GO:0071430
name: pre-microRNA-containing ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex that contains pre-microRNA from the nucleus to the cytoplasm." [GOC:mah]
synonym: "pre-microRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "pre-microRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "pre-microRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "pre-microRNA-containing RNP export from nucleus" EXACT [GOC:mah]
is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus

[Term]
id: GO:0071431
name: tRNA-containing ribonucleoprotein complex export from nucleus
namespace: biological_process
def: "The directed movement of a ribonucleoprotein complex that contains transfer RNA from the nucleus to the cytoplasm." [GOC:mah]
synonym: "tRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah]
synonym: "tRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah]
synonym: "tRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah]
synonym: "tRNA-containing RNP export from nucleus" EXACT [GOC:mah]
is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus

[Term]
id: GO:0071432
name: peptide mating pheromone maturation involved in conjugation with cellular fusion
namespace: biological_process
def: "The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of conjugation with cellular fusion." [GOC:mah]
synonym: "a-factor processing (proteolytic)" NARROW [GOC:vw]
synonym: "alpha-factor maturation" NARROW [GOC:vw]
synonym: "mating-type peptide pheromone maturation involved in conjugation with cellular fusion" EXACT [GOC:mah]
synonym: "peptide mating pheromone formation involved in conjugation with cellular fusion" EXACT [GOC:mah]
synonym: "peptide mating pheromone processing involved in conjugation with cellular fusion" EXACT [GOC:mah]
is_a: GO:0007323 ! peptide pheromone maturation
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0071433
name: cell wall repair
namespace: biological_process
def: "A process of cell wall organization that results in the restoration of the cell wall following damage." [GOC:mah, GOC:vw]
is_a: GO:0007047 ! cellular cell wall organization

[Term]
id: GO:0071434
name: cell chemotaxis to angiotensin
namespace: biological_process
def: "The directed movement of a motile cell in response to the presence of angiotensin." [GOC:mah]
synonym: "angiotensin mediated chemotaxis" BROAD [GOC:mah]
synonym: "angiotensin-mediated cell chemotaxis" EXACT [GOC:mah]
is_a: GO:0060326 ! cell chemotaxis

[Term]
id: GO:0071435
name: potassium ion export
namespace: biological_process
def: "The directed movement of potassium ions out of a cell or organelle." [GOC:mah]
synonym: "potassium export" EXACT [GOC:mah]
is_a: GO:0006813 ! potassium ion transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0071436
name: sodium ion export
namespace: biological_process
def: "The directed movement of sodium ions out of a cell or organelle." [GOC:mah]
synonym: "sodium export" EXACT [GOC:mah]
is_a: GO:0006814 ! sodium ion transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0071437
name: invadopodium
namespace: cellular_component
def: "A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate." [GOC:mah, PMID:16651416, PMID:19491051, PMID:19931459]
is_a: GO:0042995 ! cell projection

[Term]
id: GO:0071438
name: invadopodium membrane
namespace: cellular_component
def: "The portion of the plasma membrane surrounding an invadopodium." [GOC:mah]
is_a: GO:0031253 ! cell projection membrane
relationship: part_of GO:0071437 ! invadopodium

[Term]
id: GO:0071439
name: clathrin complex
namespace: cellular_component
def: "A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface." [GOC:mah, PMID:16493411]
synonym: "clathrin triskelion" EXACT [GOC:mah]
is_a: GO:0043234 ! protein complex
relationship: part_of GO:0030118 ! clathrin coat

[Term]
id: GO:0071440
name: regulation of histone H3-K14 acetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah]
synonym: "regulation of histone H3 acetylation at K14" EXACT [GOC:mah]
synonym: "regulation of histone H3K14 acetylation" EXACT [GOC:mah]
is_a: GO:0035065 ! regulation of histone acetylation
relationship: regulates GO:0044154 ! histone H3-K14 acetylation

[Term]
id: GO:0071441
name: negative regulation of histone H3-K14 acetylation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah]
synonym: "down regulation of histone H3-K14 acetylation" EXACT [GOC:mah]
synonym: "down-regulation of histone H3-K14 acetylation" EXACT [GOC:mah]
synonym: "downregulation of histone H3-K14 acetylation" EXACT [GOC:mah]
synonym: "inhibition of histone H3-K14 acetylation" NARROW [GOC:mah]
synonym: "negative regulation of histone H3 acetylation at K14" EXACT [GOC:mah]
synonym: "negative regulation of histone H3K14 acetylation" EXACT [GOC:mah]
is_a: GO:0035067 ! negative regulation of histone acetylation
is_a: GO:0071440 ! regulation of histone H3-K14 acetylation
relationship: negatively_regulates GO:0044154 ! histone H3-K14 acetylation

[Term]
id: GO:0071442
name: positive regulation of histone H3-K14 acetylation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah]
synonym: "activation of histone H3-K14 acetylation" NARROW [GOC:mah]
synonym: "positive regulation of histone H3 acetylation at K14" EXACT [GOC:mah]
synonym: "positive regulation of histone H3K14 acetylation" EXACT [GOC:mah]
synonym: "stimulation of histone H3-K14 acetylation" NARROW [GOC:mah]
synonym: "up regulation of histone H3-K14 acetylation" EXACT [GOC:mah]
synonym: "up-regulation of histone H3-K14 acetylation" EXACT [GOC:mah]
synonym: "upregulation of histone H3-K14 acetylation" EXACT [GOC:mah]
is_a: GO:0035066 ! positive regulation of histone acetylation
is_a: GO:0071440 ! regulation of histone H3-K14 acetylation
relationship: positively_regulates GO:0044154 ! histone H3-K14 acetylation

[Term]
id: GO:0071443
name: tDNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with DNA sequences encoding transfer RNA." [GOC:mah]
is_a: GO:0043565 ! sequence-specific DNA binding

[Term]
id: GO:0071444
name: cellular response to pheromone
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:mah]
subset: gosubset_prok
synonym: "cellular pheromone response" EXACT [GOC:mah]
is_a: GO:0019236 ! response to pheromone
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071445
name: cellular response to protein stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus." [GOC:mah]
subset: gosubset_prok
is_a: GO:0051789 ! response to protein stimulus
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071446
name: cellular response to salicylic acid stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:mah]
is_a: GO:0009751 ! response to salicylic acid stimulus
is_a: GO:0071310 ! cellular response to organic substance

[Term]
id: GO:0071447
name: cellular response to hydroperoxide
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH." [GOC:mah]
subset: gosubset_prok
is_a: GO:0033194 ! response to hydroperoxide
is_a: GO:0034599 ! cellular response to oxidative stress

[Term]
id: GO:0071448
name: cellular response to alkyl hydroperoxide
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group." [GOC:mah]
is_a: GO:0033195 ! response to alkyl hydroperoxide
is_a: GO:0071447 ! cellular response to hydroperoxide

[Term]
id: GO:0071449
name: cellular response to lipid hydroperoxide
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to LHPO" EXACT [GOC:mah]
is_a: GO:0006982 ! response to lipid hydroperoxide
is_a: GO:0071447 ! cellular response to hydroperoxide

[Term]
id: GO:0071450
name: cellular response to oxygen radical
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:mah]
subset: gosubset_prok
is_a: GO:0000305 ! response to oxygen radical
is_a: GO:0034614 ! cellular response to reactive oxygen species

[Term]
id: GO:0071451
name: cellular response to superoxide
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:mah]
subset: gosubset_prok
is_a: GO:0000303 ! response to superoxide
is_a: GO:0071450 ! cellular response to oxygen radical

[Term]
id: GO:0071452
name: cellular response to singlet oxygen
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:mah]
subset: gosubset_prok
is_a: GO:0000304 ! response to singlet oxygen
is_a: GO:0034614 ! cellular response to reactive oxygen species

[Term]
id: GO:0071453
name: cellular response to oxygen levels
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:mah]
is_a: GO:0070482 ! response to oxygen levels
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071454
name: cellular response to anoxia
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:mah]
comment: Note that this term should not be confused with 'cellular response to hypoxia ; GO:0071456'.
synonym: "cellular response to anoxic stress" EXACT [GOC:mah]
is_a: GO:0034059 ! response to anoxia
is_a: GO:0071453 ! cellular response to oxygen levels

[Term]
id: GO:0071455
name: cellular response to hyperoxia
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension." [GOC:mah]
synonym: "cellular response to hyperoxic stress" EXACT [GOC:mah]
synonym: "cellular response to increased oxygen tension" EXACT [GOC:mah]
is_a: GO:0055093 ! response to hyperoxia
is_a: GO:0071453 ! cellular response to oxygen levels

[Term]
id: GO:0071456
name: cellular response to hypoxia
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah]
comment: Note that this term should not be confused with 'cellular response to anoxia ; GO:0071454'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%.
synonym: "cellular response to hypoxic stress" EXACT [GOC:mah]
synonym: "cellular response to lowered oxygen tension" EXACT [GOC:mah]
is_a: GO:0001666 ! response to hypoxia
is_a: GO:0071453 ! cellular response to oxygen levels

[Term]
id: GO:0071457
name: cellular response to ozone
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:mah]
is_a: GO:0010193 ! response to ozone
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071458
name: integral to cytosolic side of endoplasmic reticulum membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of the endoplasmic reticulum membrane, with the bulk of the gene product located on the side that faces the cytosol." [GOC:mah]
synonym: "integral to cytosolic side of ER membrane" EXACT [GOC:mah]
synonym: "integral to ER membrane, cytosolic side" EXACT [GOC:vw]
is_a: GO:0030176 ! integral to endoplasmic reticulum membrane

[Term]
id: GO:0071459
name: protein localization to chromosome, centromeric region
namespace: biological_process
def: "Any process by which a protein is transported to, or maintained at, the centromeric region of a chromosome." [GOC:mah]
synonym: "protein localization to centromere" EXACT [GOC:mah]
synonym: "protein localization to chromosome, centric region" EXACT [GOC:mah]
is_a: GO:0034502 ! protein localization to chromosome

[Term]
id: GO:0071460
name: cellular response to cell-matrix adhesion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion." [GOC:sl, PMID:11425869]
is_a: GO:0031668 ! cellular response to extracellular stimulus

[Term]
id: GO:0071461
name: cellular response to redox state
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah]
subset: gosubset_prok
synonym: "cellular redox signal response" EXACT [GOC:mah]
is_a: GO:0051775 ! response to redox state

[Term]
id: GO:0071462
name: cellular response to water
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus." [GOC:mah]
subset: gosubset_prok
is_a: GO:0009415 ! response to water
is_a: GO:0070887 ! cellular response to chemical stimulus
is_a: GO:0071214 ! cellular response to abiotic stimulus

[Term]
id: GO:0071463
name: cellular response to humidity
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:mah]
is_a: GO:0009270 ! response to humidity
is_a: GO:0071462 ! cellular response to water

[Term]
id: GO:0071464
name: cellular response to hydrostatic pressure
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [GOC:mah]
synonym: "cellular response to biomechanical stress" BROAD [GOC:mah]
synonym: "cellular response to static fluid pressure" EXACT [GOC:mah]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0051599 ! response to hydrostatic pressure
is_a: GO:0071462 ! cellular response to water

[Term]
id: GO:0071465
name: cellular response to desiccation
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:mah]
subset: gosubset_prok
synonym: "desiccation tolerance" RELATED [GOC:mah]
is_a: GO:0009269 ! response to desiccation
is_a: GO:0042631 ! cellular response to water deprivation

[Term]
id: GO:0071466
name: cellular response to xenobiotic stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms." [GOC:mah]
subset: gosubset_prok
is_a: GO:0009410 ! response to xenobiotic stimulus
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0071467
name: cellular response to pH
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus." [GOC:mah]
subset: gosubset_prok
is_a: GO:0009268 ! response to pH
is_a: GO:0071214 ! cellular response to abiotic stimulus

[Term]
id: GO:0071468
name: cellular response to acidity
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7." [GOC:mah]
synonym: "cellular response to acidic pH" EXACT [GOC:mah]
is_a: GO:0010447 ! response to acidity
is_a: GO:0071467 ! cellular response to pH

[Term]
id: GO:0071469
name: cellular response to alkalinity
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7." [GOC:mah]
synonym: "cellular response to alkaline pH" EXACT [GOC:mah]
synonym: "cellular response to basic pH" EXACT [GOC:mah]
is_a: GO:0010446 ! response to alkalinity
is_a: GO:0071467 ! cellular response to pH

[Term]
id: GO:0071470
name: cellular response to osmotic stress
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah]
subset: gosubset_prok
synonym: "cellular osmotic response" EXACT [GOC:mah]
synonym: "cellular osmotic stress response" EXACT [GOC:mah]
is_a: GO:0006970 ! response to osmotic stress
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0071214 ! cellular response to abiotic stimulus

[Term]
id: GO:0071471
name: cellular response to non-ionic osmotic stress
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:mah]
is_a: GO:0010335 ! response to non-ionic osmotic stress
is_a: GO:0071470 ! cellular response to osmotic stress

[Term]
id: GO:0071472
name: cellular response to salt stress
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to ionic osmotic stress" EXACT [GOC:mah]
synonym: "cellular salinity response" EXACT [GOC:mah]
is_a: GO:0009651 ! response to salt stress
is_a: GO:0071470 ! cellular response to osmotic stress

[Term]
id: GO:0071473
name: cellular response to cation stress
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:mah]
subset: gosubset_prok
is_a: GO:0043157 ! response to cation stress
is_a: GO:0071472 ! cellular response to salt stress

[Term]
id: GO:0071474
name: cellular hyperosmotic response
namespace: biological_process
def: "A change in state or activity of a cell or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:mah]
synonym: "cellular HOG response" EXACT [GOC:mah]
synonym: "cellular hypertonic response" EXACT [GOC:mah]
is_a: GO:0006972 ! hyperosmotic response
is_a: GO:0071470 ! cellular response to osmotic stress

[Term]
id: GO:0071475
name: cellular hyperosmotic salinity response
namespace: biological_process
def: "A change in state or activity of a cell or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah]
synonym: "cellular response to hyperosmotic salt stress" EXACT [GOC:mah]
is_a: GO:0042538 ! hyperosmotic salinity response
is_a: GO:0071472 ! cellular response to salt stress
is_a: GO:0071474 ! cellular hyperosmotic response

[Term]
id: GO:0071476
name: cellular hypotonic response
namespace: biological_process
def: "A change in state or activity of a cell or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:mah]
synonym: "cellular hypo-osmotic response" EXACT [GOC:mah]
is_a: GO:0006971 ! hypotonic response
is_a: GO:0071470 ! cellular response to osmotic stress

[Term]
id: GO:0071477
name: cellular hypotonic salinity response
namespace: biological_process
def: "A change in state or activity of a cell or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah]
synonym: "cellular response to hypotonic salt stress" EXACT [GOC:mah]
is_a: GO:0042539 ! hypotonic salinity response
is_a: GO:0071472 ! cellular response to salt stress
is_a: GO:0071476 ! cellular hypotonic response

[Term]
id: GO:0071478
name: cellular response to radiation
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:mah]
comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength.
subset: gosubset_prok
synonym: "cellular response to electromagnetic radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to radiation stimulus" EXACT [GOC:mah]
is_a: GO:0009314 ! response to radiation
is_a: GO:0071214 ! cellular response to abiotic stimulus

[Term]
id: GO:0071479
name: cellular response to ionizing radiation
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah]
synonym: "cellular response to ionising radiation" EXACT [GOC:mah]
synonym: "cellular response to ionizing radiation stimulus" EXACT [GOC:mah]
is_a: GO:0010212 ! response to ionizing radiation
is_a: GO:0071478 ! cellular response to radiation

[Term]
id: GO:0071480
name: cellular response to gamma radiation
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah]
synonym: "cellular response to gamma ray" RELATED [GOC:mah]
synonym: "cellular response to gamma-ray photon" RELATED [GOC:mah]
is_a: GO:0010332 ! response to gamma radiation
is_a: GO:0071479 ! cellular response to ionizing radiation

[Term]
id: GO:0071481
name: cellular response to X-ray
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:mah]
synonym: "cellular response to X-ray radiation stimulus" EXACT [GOC:mah]
is_a: GO:0010165 ! response to X-ray
is_a: GO:0071479 ! cellular response to ionizing radiation

[Term]
id: GO:0071482
name: cellular response to light stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah]
subset: gosubset_prok
is_a: GO:0009416 ! response to light stimulus
is_a: GO:0071478 ! cellular response to radiation

[Term]
id: GO:0071483
name: cellular response to blue light
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:mah]
synonym: "cellular response to blue light stimulus" EXACT [GOC:mah]
is_a: GO:0009637 ! response to blue light
is_a: GO:0071482 ! cellular response to light stimulus

[Term]
id: GO:0071484
name: cellular response to light intensity
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:mah]
is_a: GO:0009642 ! response to light intensity
is_a: GO:0071482 ! cellular response to light stimulus

[Term]
id: GO:0071485
name: cellular response to absence of light
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:mah]
is_a: GO:0009646 ! response to absence of light
is_a: GO:0071484 ! cellular response to light intensity

[Term]
id: GO:0071486
name: cellular response to high light intensity
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:mah]
is_a: GO:0009644 ! response to high light intensity
is_a: GO:0071484 ! cellular response to light intensity

[Term]
id: GO:0071487
name: cellular response to low light intensity stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:mah]
is_a: GO:0009645 ! response to low light intensity stimulus
is_a: GO:0071484 ! cellular response to light intensity

[Term]
id: GO:0071488
name: cellular response to very low light intensity stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec." [GOC:mah]
is_a: GO:0055122 ! response to very low light intensity stimulus
is_a: GO:0071484 ! cellular response to light intensity

[Term]
id: GO:0071489
name: cellular response to red or far red light
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah]
is_a: GO:0009639 ! response to red or far red light
is_a: GO:0071482 ! cellular response to light stimulus

[Term]
id: GO:0071490
name: cellular response to far red light
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah]
synonym: "cellular response to far red light stimulus" EXACT [GOC:mah]
is_a: GO:0010218 ! response to far red light
is_a: GO:0071489 ! cellular response to red or far red light

[Term]
id: GO:0071491
name: cellular response to red light
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah]
synonym: "cellular response to red light stimulus" EXACT [GOC:mah]
is_a: GO:0010114 ! response to red light
is_a: GO:0071489 ! cellular response to red or far red light

[Term]
id: GO:0071492
name: cellular response to UV-A
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 400 to 500 nm." [GOC:mah]
synonym: "cellular response to UV-A light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UV-A radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVA light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVA radiation stimulus" EXACT [GOC:mah]
is_a: GO:0034644 ! cellular response to UV
is_a: GO:0070141 ! response to UV-A

[Term]
id: GO:0071493
name: cellular response to UV-B
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 290 to 320 nm." [GOC:mah]
synonym: "cellular response to medium wave ultraviolet light stimulus" EXACT [GOC:mah]
synonym: "cellular response to medium wave ultraviolet radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to UV-B light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UV-B radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVB light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVB radiation stimulus" EXACT [GOC:mah]
is_a: GO:0010224 ! response to UV-B
is_a: GO:0034644 ! cellular response to UV

[Term]
id: GO:0071494
name: cellular response to UV-C
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 290 nm." [GOC:mah]
synonym: "cellular response to germicidal ultraviolet light stimulus" EXACT [GOC:mah]
synonym: "cellular response to germicidal ultraviolet radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to shortwave ultraviolet light stimulus" EXACT [GOC:mah]
synonym: "cellular response to shortwave ultraviolet radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to UV-C light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UV-C radiation stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVC light stimulus" EXACT [GOC:mah]
synonym: "cellular response to UVC radiation stimulus" EXACT [GOC:mah]
is_a: GO:0010225 ! response to UV-C
is_a: GO:0034644 ! cellular response to UV

[Term]
id: GO:0071495
name: cellular response to endogenous stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah]
subset: gosubset_prok
is_a: GO:0009719 ! response to endogenous stimulus

[Term]
id: GO:0071496
name: cellular response to external stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to environmental stimulus" EXACT [GOC:mah]
is_a: GO:0009605 ! response to external stimulus

[Term]
id: GO:0071497
name: cellular response to freezing
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:mah]
subset: gosubset_prok
synonym: "antifreeze activity" RELATED [GOC:mah]
synonym: "ice nucleation inhibitor activity" RELATED [GOC:mah]
is_a: GO:0050826 ! response to freezing
is_a: GO:0070417 ! cellular response to cold

[Term]
id: GO:0071498
name: cellular response to fluid shear stress
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface." [GOC:mah]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0034405 ! response to fluid shear stress

[Term]
id: GO:0071499
name: cellular response to laminar fluid shear stress
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers." [GOC:mah]
is_a: GO:0034616 ! response to laminar fluid shear stress
is_a: GO:0071498 ! cellular response to fluid shear stress

[Term]
id: GO:0071500
name: cellular response to nitrosative stress
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GOC:mah]
is_a: GO:0033554 ! cellular response to stress
is_a: GO:0051409 ! response to nitrosative stress

[Term]
id: GO:0071501
name: cellular response to sterol depletion
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:mah]
synonym: "cellular sterol depletion response" EXACT [GOC:mah]
is_a: GO:0006991 ! response to sterol depletion
is_a: GO:0033554 ! cellular response to stress

[Term]
id: GO:0071502
name: cellular response to temperature stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:mah]
subset: gosubset_prok
synonym: "cellular response to thermal stimulus" EXACT [GOC:mah]
is_a: GO:0009266 ! response to temperature stimulus

[Term]
id: GO:0071503
name: response to heparin
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus." [GOC:mah]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0071504
name: cellular response to heparin
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus." [GOC:mah]
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0071503 ! response to heparin

[Term]
id: GO:0071505
name: response to mycophenolic acid
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus." [ChEBI:168396, GOC:mah]
synonym: "response to mycophenolate" EXACT [GOC:mah]
is_a: GO:0070542 ! response to fatty acid

[Term]
id: GO:0071506
name: cellular response to mycophenolic acid
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus." [ChEBI:168396, GOC:mah]
synonym: "cellular response to mycophenolate" EXACT [GOC:mah]
is_a: GO:0071398 ! cellular response to fatty acid
is_a: GO:0071505 ! response to mycophenolic acid

[Term]
id: GO:0071507
name: MAPKKK cascade involved in conjugation with cellular fusion
namespace: biological_process
def: "A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of conjugation with cellular fusion." [GOC:mah, GOC:vw]
synonym: "conjugation with cellular fusion, MAPKKK cascade" EXACT [GOC:mah]
synonym: "MAPKKK cascade involved in mating response" RELATED [GOC:mah]
is_a: GO:0000165 ! MAPKKK cascade
relationship: part_of GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion

[Term]
id: GO:0071508
name: activation of MAPK activity involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase in the context of conjugation with cellular fusion." [GOC:mah]
synonym: "activation of MAPK activity involved in mating response" RELATED [GOC:mah]
synonym: "conjugation with cellular fusion, activation of MAPK activity" EXACT [GOC:mah]
is_a: GO:0000187 ! activation of MAPK activity
relationship: part_of GO:0071507 ! MAPKKK cascade involved in conjugation with cellular fusion

[Term]
id: GO:0071509
name: activation of MAPKK activity involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of conjugation with cellular fusion." [GOC:mah]
synonym: "activation of MAP kinase kinase activity during conjugation with cellular fusion" EXACT [GOC:mah]
synonym: "activation of MAPKK activity involved in mating response" RELATED [GOC:mah]
synonym: "conjugation with cellular fusion, activation of MAP kinase kinase activity" EXACT [GOC:mah]
synonym: "conjugation with cellular fusion, activation of MAPKK activity" EXACT [GOC:mah]
is_a: GO:0000186 ! activation of MAPKK activity
relationship: part_of GO:0071507 ! MAPKKK cascade involved in conjugation with cellular fusion

[Term]
id: GO:0071510
name: activation of MAPKKK activity involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of conjugation with cellular fusion." [GOC:mah]
synonym: "activation of MAP kinase kinase kinase activity during conjugation with cellular fusion" EXACT [GOC:mah]
synonym: "activation of MAPKKK activity involved in mating response" RELATED [GOC:mah]
synonym: "conjugation with cellular fusion, activation of MAP kinase kinase kinase activity" EXACT [GOC:mah]
synonym: "conjugation with cellular fusion, activation of MAPKKK activity" EXACT [GOC:mah]
is_a: GO:0000185 ! activation of MAPKKK activity
relationship: part_of GO:0071507 ! MAPKKK cascade involved in conjugation with cellular fusion

[Term]
id: GO:0071511
name: inactivation of MAPK activity involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that terminates the activity of the active enzyme MAP kinase in the context of conjugation with cellular fusion." [GOC:mah]
synonym: "conjugation with cellular fusion, inactivation of MAPK activity" EXACT [GOC:mah]
synonym: "conjugation with cellular fusion, termination of MAPK activity" EXACT [GOC:mah]
synonym: "inactivation of MAPK activity involved in mating response" RELATED [GOC:mah]
synonym: "termination of MAPK activity during conjugation with cellular fusion" EXACT [GOC:mah]
is_a: GO:0000188 ! inactivation of MAPK activity
relationship: part_of GO:0071507 ! MAPKKK cascade involved in conjugation with cellular fusion

[Term]
id: GO:0071512
name: nuclear translocation of MAPK involved in conjugation with cellular fusion
namespace: biological_process
def: "The directed movement of a MAP kinase to the nucleus that occurs in the context of conjugation with cellular fusion." [GOC:mah]
synonym: "conjugation with cellular fusion, nuclear translocation of MAPK" EXACT [GOC:mah]
synonym: "nuclear translocation of MAPK involved in mating response" RELATED [GOC:mah]
is_a: GO:0000189 ! nuclear translocation of MAPK
relationship: part_of GO:0071507 ! MAPKKK cascade involved in conjugation with cellular fusion

[Term]
id: GO:0071513
name: phosphopantothenoylcysteine decarboxylase complex
namespace: cellular_component
def: "A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces." [GOC:jh, PMID:19915539]
comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'.
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0071514
name: genetic imprinting
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules by a mechanism that is mediated by DNA, is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence." [GOC:mah, GOC:vw]
synonym: "DNA imprinting" EXACT [GOC:mah]
is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
is_a: GO:0060255 ! regulation of macromolecule metabolic process

[Term]
id: GO:0071515
name: genetic imprinting at mating-type locus
namespace: biological_process
def: "A genetic imprinting process in which a stable single-strand DNA lesion triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:14765111, PMID:18723894]
synonym: "mating type determination, imprinting" EXACT [GOC:vw]
is_a: GO:0006259 ! DNA metabolic process
is_a: GO:0031494 ! regulation of mating type switching
is_a: GO:0071514 ! genetic imprinting

[Term]
id: GO:0071516
name: establishment of imprinting at mating-type locus
namespace: biological_process
def: "The initial formation of a stable single-strand DNA lesion that triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:0, PMID:18723894]
synonym: "mating type determination, establishment of imprinting" EXACT [GOC:vw]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0071515 ! genetic imprinting at mating-type locus

[Term]
id: GO:0071517
name: maintenance of imprinting at mating-type locus
namespace: biological_process
def: "Any process involved in preserving the structure of a stable single-strand DNA lesion that triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:14765111, PMID:18723894]
synonym: "mating type determination, maintenance of imprinting" EXACT [GOC:mah]
is_a: GO:0006259 ! DNA metabolic process
relationship: part_of GO:0071515 ! genetic imprinting at mating-type locus

[Term]
id: GO:0071518
name: autoinducer-2 kinase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,5-dihydroxy-pentane-2,3-dione + ATP = 5-phospho-4-hydroxy-pentane-2,3-dione (P-DPD) + ADP." [GOC:imk, PMID:17274596, PMID:20025244]
synonym: "4,5-dihydroxy-pentane-2,3-dione kinase activity" EXACT [ChEBI:425228, GOC:mah]
xref: MetaCyc:RXN0-5461
is_a: GO:0016301 ! kinase activity

[Term]
id: GO:0071519
name: actin filament bundle assembly involved in actomyosin contractile ring formation
namespace: biological_process
def: "A process of actin filament bundle formation that occurs in the context of assembling an actomyosin contractile ring during cytokinesis." [GOC:mah, PMID:19713940]
is_a: GO:0051017 ! actin filament bundle assembly
relationship: part_of GO:0000915 ! cytokinesis, actomyosin contractile ring assembly

[Term]
id: GO:0071520
name: actin filament bundle convergence involved in actomyosin contractile ring formation
namespace: biological_process
def: "A process of actin filament bundle distribution that occurs in the context of assembling an actomyosin contractile ring during cytokinesis, and that results in the compaction of actin filaments into a tight ring." [GOC:mah, PMID:19713940]
is_a: GO:0070650 ! actin filament bundle distribution
relationship: part_of GO:0000915 ! cytokinesis, actomyosin contractile ring assembly

[Term]
id: GO:0071521
name: Cdc42 GTPase complex
namespace: cellular_component
def: "A protein complex formed by the association of the small GTPase Cdc42 with additional proteins. In Schizosaccharomyces the complex contains the Cdc42, Ras1, Scd1, Scd2, andShk1 proteins, and functions in the Ras1-Scd GTPase signalling pathway." [GOC:mah, GOC:vw, PMID:10567532, PMID:7923372, PMID:8943016]
synonym: "Ras1-Scd1-Scd2-Cdc42-Shk1 complex" EXACT [GOC:vw]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0071522
name: ureidoglycine aminohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ureidoglycine + H2O = S-ureidoglycolate + NH3." [MetaCyc:URUR-RXN, PMID:19935661, PMID:20038185]
subset: gosubset_prok
xref: EC:3.5.3.-
xref: MetaCyc:URUR-RXN
is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

[Term]
id: GO:0071523
name: TIR domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a TIR domain interaction." [GOC:amm]
is_a: GO:0006461 ! protein complex assembly

[Term]
id: GO:0071524
name: pyrrolysine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine." [ChEBI:21860, GOC:dh, PMID:17204561]
subset: gosubset_prok
synonym: "monomethylamine methyltransferase cofactor lysine adduct biosynthetic process" EXACT [ChEBI:21860]
synonym: "pyrrolysine anabolism" EXACT [GOC:mah]
synonym: "pyrrolysine biosynthesis" EXACT [GOC:mah]
synonym: "pyrrolysine formation" EXACT [GOC:mah]
synonym: "pyrrolysine synthesis" EXACT [GOC:mah]
is_a: GO:0008652 ! cellular amino acid biosynthetic process
is_a: GO:0071525 ! pyrrolysine metabolic process

[Term]
id: GO:0071525
name: pyrrolysine metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine." [ChEBI:21860, GOC:mah, PMID:17204561]
subset: gosubset_prok
synonym: "monomethylamine methyltransferase cofactor lysine adduct metabolic process" EXACT [ChEBI:21860]
synonym: "pyrrolysine metabolism" EXACT [GOC:mah]
is_a: GO:0006520 ! cellular amino acid metabolic process

[Term]
id: GO:0071526
name: semaphorin-plexin signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959]
is_a: GO:0007166 ! cell surface receptor linked signaling pathway

[Term]
id: GO:0071527
name: semaphorin-plexin signaling pathway involved in outflow tract morphogenesis
namespace: biological_process
def: "A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand that contributes to outflow tract morphogenesis." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959]
is_a: GO:0071526 ! semaphorin-plexin signaling pathway
relationship: part_of GO:0003151 ! outflow tract morphogenesis

[Term]
id: GO:0071528
name: tRNA re-export from nucleus
namespace: biological_process
def: "The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export." [GOC:mcc, PMID:17475781, PMID:20032305]
synonym: "tRNA reexport from nucleus" EXACT [GOC:mcc]
is_a: GO:0006409 ! tRNA export from nucleus

[Term]
id: GO:0071529
name: cementum mineralization
namespace: biological_process
def: "The process by which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum." [GOC:sl, PMID:17043865]
synonym: "cementum formation" RELATED [GOC:mah]
is_a: GO:0034505 ! tooth mineralization

[Term]
id: GO:0071530
name: FHA domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an FHA (forkhead-associated) domain interaction." [GOC:amm, InterPro:IPR000253]
synonym: "forkhead-associated domain-mediated complex assembly" EXACT [GOC:mah]
is_a: GO:0006461 ! protein complex assembly

[Term]
id: GO:0071531
name: Rel homology domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an FHA (forkhead-associated) domain interaction." [GOC:amm, InterPro:IPR011539]
synonym: "RHD domain-mediated complex assembly" EXACT [GOC:mah]
is_a: GO:0006461 ! protein complex assembly

[Term]
id: GO:0071532
name: ankyrin repeat binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure." [GOC:mah, InterPro:IPR002110]
synonym: "ANK repeat binding" EXACT [GOC:amm]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0071533
name: ankyrin repeat-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an ankyrin repeat interaction." [GOC:amm, InterPro:IPR002110]
synonym: "ANK repeat-mediated complex assembly" EXACT [GOC:amm]
is_a: GO:0006461 ! protein complex assembly

[Term]
id: GO:0071534
name: zf-TRAF domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a TRAF-type zinc finger (zf-TRAF) domain interaction." [GOC:amm, InterPro:IPR001293]
synonym: "TRAF-type zinc finger domain-mediated complex assembly" EXACT [GOC:mah]
synonym: "zinc finger TRAF-type domain-mediated complex assembly" EXACT [GOC:mah]
synonym: "zinc-finger-TRAF domain-mediated complex assembly" EXACT [GOC:mah]
is_a: GO:0006461 ! protein complex assembly

[Term]
id: GO:0071535
name: RING-like zinc finger domain binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain." [GOC:mah, InterPro:IPR014857]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0071536
name: RING-like zinc finger domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a RING-like zinc finger domain interaction." [GOC:amm, InterPro:IPR014857]
synonym: "RING-like domain-mediated complex assembly" EXACT [GOC:mah]
is_a: GO:0006461 ! protein complex assembly

[Term]
id: GO:0071537
name: C3HC4-type RING finger domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a C3HC4-type RING finger domain interaction." [GOC:amm, InterPro:IPR018957]
synonym: "zinc finger C3HC4 type domain-mediated complex assembly" EXACT [GOC:amm]
is_a: GO:0006461 ! protein complex assembly

[Term]
id: GO:0071538
name: SH2 domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an SH2 domain interaction." [GOC:amm]
is_a: GO:0006461 ! protein complex assembly

[Term]
id: GO:0071539
name: protein localization to centrosome
namespace: biological_process
def: "A process by which a protein is transported to, or maintained at, the centrosome." [GOC:ecd]
is_a: GO:0033365 ! protein localization in organelle

[Term]
id: GO:0071540
name: eukaryotic translation initiation factor 3 complex, eIF3e
namespace: cellular_component
def: "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e." [PMID:15904532, PMID:19061185]
synonym: "eIF3e-containing eukaryotic translation initiation factor 3 complex" EXACT [GOC:mah]
is_a: GO:0005852 ! eukaryotic translation initiation factor 3 complex

[Term]
id: GO:0071541
name: eukaryotic translation initiation factor 3 complex, eIF3m
namespace: cellular_component
def: "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185]
synonym: "eIF3m-containing eukaryotic translation initiation factor 3 complex" EXACT [GOC:mah]
is_a: GO:0005852 ! eukaryotic translation initiation factor 3 complex

[Term]
id: GO:0071542
name: dopaminergic neuron differentiation
namespace: biological_process
def: "The process whereby a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine." [GOC:rph]
is_a: GO:0030182 ! neuron differentiation

[Term]
id: GO:0071543
name: diphosphoinositol polyphosphate metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached." [GOC:mah, PMID:12387729]
synonym: "diphosphoinositol polyphosphate metabolism" EXACT [GOC:mah]
is_a: GO:0043647 ! inositol phosphate metabolic process

[Term]
id: GO:0071544
name: diphosphoinositol polyphosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached." [GOC:mah, PMID:12387729]
synonym: "diphosphoinositol polyphosphate breakdown" EXACT [GOC:mah]
synonym: "diphosphoinositol polyphosphate catabolism" EXACT [GOC:mah]
synonym: "diphosphoinositol polyphosphate degradation" EXACT [GOC:mah]
is_a: GO:0071543 ! diphosphoinositol polyphosphate metabolic process
is_a: GO:0071545 ! inositol phosphate catabolic process

[Term]
id: GO:0071545
name: inositol phosphate catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [ChEBI:24848, ChEBI:25448, GOC:mah]
comment: See also the biological process term 'inositol and derivative phosphorylation ; GO:0046853'.
synonym: "inositol phosphate breakdown" EXACT [GOC:mah]
synonym: "inositol phosphate catabolism" EXACT [GOC:mah]
synonym: "inositol phosphate degradation" EXACT [GOC:mah]
synonym: "myo-inositol phosphate catabolic process" NARROW [GOC:mah]
is_a: GO:0019310 ! inositol catabolic process
is_a: GO:0043647 ! inositol phosphate metabolic process

[Term]
id: GO:0071546
name: pi-body
namespace: cellular_component
def: "A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes." [GOC:sp, PMID:20011505]
synonym: "intermitochondrial cement" EXACT [GOC:sp]
is_a: GO:0043186 ! P granule

[Term]
id: GO:0071547
name: piP-body
namespace: cellular_component
def: "A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway." [GOC:sp, PMID:20011505]
is_a: GO:0043186 ! P granule

[Term]
id: GO:0071548
name: response to dexamethasone stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus." [GOC:mah, GOC:yaf]
is_a: GO:0051384 ! response to glucocorticoid stimulus

[Term]
id: GO:0071549
name: cellular response to dexamethasone stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus." [GOC:mah, GOC:yaf]
is_a: GO:0051414 ! response to cortisol stimulus
is_a: GO:0071385 ! cellular response to glucocorticoid stimulus
is_a: GO:0071548 ! response to dexamethasone stimulus

[Term]
id: GO:0071550
name: death domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction." [GOC:amm, InterPro:IPR000488]
synonym: "DD-mediated complex assembly" EXACT [GOC:mah]
is_a: GO:0006461 ! protein complex assembly

[Term]
id: GO:0071551
name: RIP homotypic interaction motif binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a RIP homotypic interaction motif (RHIM) of a protein. The RHIM is a 16-amino-acid motif found in some members, including RIP3, of a family of related kinases." [GOC:mah, PMID:11734559]
synonym: "RHIM binding" EXACT [GOC:mah]
is_a: GO:0019904 ! protein domain specific binding

[Term]
id: GO:0071552
name: RIP homotypic interaction motif-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a RIP homotypic interaction motif (RHIM) interaction." [GOC:amm, PMID:11734559]
synonym: "RHIM-mediated complex assembly" EXACT [GOC:mah]
is_a: GO:0006461 ! protein complex assembly

[Term]
id: GO:0071553
name: pyrimidinergic nucleotide receptor activity, G-protein coupled
namespace: molecular_function
def: "Combining with a pyrimidine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:sl, PMID:10736418, PMID:12369950, PMID:15796906]
synonym: "G protein coupled pyrimidinergic nucleotide receptor activity" EXACT []
synonym: "G-protein coupled pyrimidinergic nucleotide receptor activity" EXACT []
synonym: "G-protein-coupled pyrimidinergic nucleotide receptor activity" EXACT []
synonym: "pyrimidinergic nucleotide receptor activity, G protein coupled" EXACT []
is_a: GO:0001608 ! nucleotide receptor activity, G-protein coupled
is_a: GO:0001614 ! purinergic nucleotide receptor activity

[Term]
id: GO:0071554
name: cell wall organization or biogenesis
namespace: biological_process
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall." [GOC:mah]
subset: goslim_pombe
subset: gosubset_prok
synonym: "cell wall organisation or biogenesis" EXACT [GOC:mah]
is_a: GO:0008150 ! biological_process

[Term]
id: GO:0071555
name: cell wall organization
namespace: biological_process
def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah]
subset: goslim_candida
subset: goslim_pir
subset: goslim_yeast
subset: gosubset_prok
synonym: "cell wall organisation" EXACT [GOC:curators]
synonym: "cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071554 ! cell wall organization or biogenesis

[Term]
id: GO:0071556
name: integral to lumenal side of endoplasmic reticulum membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of the endoplasmic reticulum membrane, with the bulk of the gene product located on the side that faces the lumen." [GOC:mah]
synonym: "integral to ER membrane, lumenal side" EXACT [GOC:vw]
synonym: "integral to lumenal side of ER membrane" EXACT [GOC:mah]
is_a: GO:0030176 ! integral to endoplasmic reticulum membrane

[Term]
id: GO:0071557
name: histone H3-K27 demethylation
namespace: biological_process
def: "The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone." [GOC:sp, PMID:20023638]
synonym: "H3K27 demethylation" RELATED [GOC:mah]
is_a: GO:0070076 ! histone lysine demethylation

[Term]
id: GO:0071558
name: histone demethylase activity (H3-K27 specific)
namespace: molecular_function
def: "Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein." [GOC:sp, PMID:20023638]
is_a: GO:0032452 ! histone demethylase activity

[Term]
id: GO:0071559
name: response to transforming growth factor beta stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:mah]
synonym: "response to TGF-beta stimulus" EXACT [GOC:mah]
synonym: "response to TGFbeta stimulus" EXACT [GOC:mah]
is_a: GO:0009719 ! response to endogenous stimulus
is_a: GO:0070848 ! response to growth factor stimulus

[Term]
id: GO:0071560
name: cellular response to transforming growth factor beta stimulus
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:ecd, PMID:15451575]
synonym: "cellular response to TGF-beta stimulus" EXACT [GOC:mah]
synonym: "cellular response to TGFbeta stimulus" EXACT [GOC:mah]
is_a: GO:0071363 ! cellular response to growth factor stimulus
is_a: GO:0071495 ! cellular response to endogenous stimulus
is_a: GO:0071559 ! response to transforming growth factor beta stimulus

[Term]
id: GO:0071561
name: nucleus-vacuole junction
namespace: cellular_component
def: "An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p." [GOC:jp, PMID:16709156, PMID:16806880]
synonym: "nucleus-vacuole membrane contact site" EXACT [GOC:mah]
synonym: "NV junction" EXACT [GOC:jp, PMID:16709156]
synonym: "NVJ" EXACT [GOC:mah, PMID:16806880]
is_a: GO:0044232 ! organelle membrane contact site

[Term]
id: GO:0071562
name: nucleus-vacuole junction assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a nucleus-vacuole junction, which are membrane contact sites formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p." [GOC:jp, PMID:16709156]
synonym: "nucleus-vacuole junction formation" EXACT [GOC:jp]
synonym: "NV junction assembly" EXACT [GOC:jp, PMID:16709156]
synonym: "NV junction formation" EXACT [GOC:jp, PMID:16709156]
synonym: "NVJ assembly" EXACT [GOC:mah, PMID:16806880]
synonym: "NVJ formation" EXACT [GOC:mah, PMID:16806880]
is_a: GO:0022607 ! cellular component assembly
is_a: GO:0022614 ! membrane to membrane docking
relationship: part_of GO:0034727 ! piecemeal microautophagy of nucleus

[Term]
id: GO:0071563
name: Myo2p-Vac17p-Vac8p transport complex
namespace: cellular_component
def: "A protein complex that is involved in transport of vacuoles to a newly formed daughter cell. In yeast, this complex is composed of Myo2p, Vac17p, and Vac8p." [GOC:jp, PMID:12594460]
is_a: GO:0043234 ! protein complex
is_a: GO:0044444 ! cytoplasmic part

[Term]
id: GO:0071564
name: npBAF complex
namespace: cellular_component
def: "A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells." [GOC:mah, GOC:ss, PMID:17640523]
is_a: GO:0070603 ! SWI/SNF-type complex

[Term]
id: GO:0071565
name: nBAF complex
namespace: cellular_component
def: "A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth." [GOC:mah, GOC:ss, PMID:17640523]
is_a: GO:0070603 ! SWI/SNF-type complex

[Term]
id: GO:0071566
name: UFM1 activating enzyme activity
namespace: molecular_function
def: "Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:sp, PMID:20018847]
is_a: GO:0008641 ! small protein activating enzyme activity

[Term]
id: GO:0071567
name: UFM1 hydrolase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of UFM1, a small ubiquitin-related modifier, from previously modified substrates." [GOC:sp, PMID:20018847]
is_a: GO:0019783 ! small conjugating protein-specific protease activity

[Term]
id: GO:0071568
name: UFM1 conjugating enzyme activity
namespace: molecular_function
def: "Catalysis of the covalent attachment of the ubiquitin-like protein UFM1 to other proteins or other substrate molecules." [GOC:sp, PMID:20018847]
is_a: GO:0019787 ! small conjugating protein ligase activity

[Term]
id: GO:0071569
name: protein ufmylation
namespace: biological_process
def: "Covalent attachment of the ubiquitin-like protein UFM1 to another protein." [GOC:vw, PMID:20018847]
is_a: GO:0032446 ! protein modification by small protein conjugation
is_a: GO:0043687 ! post-translational protein modification

[Term]
id: GO:0071570
name: cement gland development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cement gland over time, from its formation to the mature structure. The cement gland is a simple mucus-secreting organ positioned at the anterior of amphibious embryos. The cement gland attaches the newly hatched embryo to a support before the hatchling can swim well or feed." [GOC:bf]
is_a: GO:0048732 ! gland development

[Term]
id: GO:0071571
name: LRR domain-mediated complex assembly
namespace: biological_process
def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an LRR (leucine-rich repeat) domain interaction." [GOC:amm, InterPro:IPR001611]
synonym: "leucine-rich repeat domain-mediated complex assembly" EXACT [GOC:mah]
is_a: GO:0006461 ! protein complex assembly

[Term]
id: GO:0071572
name: histone H3-K56 deacetylation
namespace: biological_process
def: "The modification of histone H3 by the removal of an acetyl group from lysine at position 56 of the histone." [GOC:mah]
is_a: GO:0070932 ! histone H3 deacetylation

[Term]
id: GO:0071573
name: telosome assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a telosome. A telosome is a nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase." [GOC:mah, GOC:vw]
synonym: "Pot1 complex assembly" EXACT [GOC:mah]
synonym: "Pot1-Tpz1 complex assembly" EXACT [GOC:mah]
synonym: "shelterin complex formation" EXACT [GOC:mah]
is_a: GO:0065004 ! protein-DNA complex assembly

[Term]
id: GO:0071574
name: protein localization to medial cortex
namespace: biological_process
def: "A process by which a protein is transported to, or maintained in, the medial cortex." [GOC:mah]
is_a: GO:0034613 ! cellular protein localization

[Term]
id: GO:0071575
name: integral to external side of plasma membrane
namespace: cellular_component
def: "Penetrating at least one phospholipid bilayer of the plasma membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm." [GOC:mah]
is_a: GO:0005887 ! integral to plasma membrane
is_a: GO:0031233 ! intrinsic to external side of plasma membrane

[Term]
id: GO:0071576
name: tetrahydrodictyopterin binding
namespace: molecular_function
def: "Interacting selectively with tetrahydrodictyopterin, the pterin 2-amino-6-[(1R,2R)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one." [ChEBI:52447, GOC:mah]
synonym: "D-threo-tetrahydrobiopterin" EXACT [GOC:mah]
synonym: "DH4 binding" EXACT [GOC:mah]
is_a: GO:0034617 ! tetrahydrobiopterin binding

[Term]
id: GO:0071577
name: zinc ion transmembrane transport
namespace: biological_process
def: "A process whereby a zinc ion is transported from one side of a membrane to the other." [GOC:BHF, GOC:mah]
synonym: "zinc transmembrane transport" EXACT [GOC:mah]
is_a: GO:0006829 ! zinc ion transport
is_a: GO:0034220 ! ion transmembrane transport

[Term]
id: GO:0071578
name: zinc ion import
namespace: biological_process
def: "The directed movement of zinc ions across a membrane into a cell or organelle." [GOC:BHF, GOC:mah]
synonym: "zinc import" EXACT [GOC:mah]
synonym: "zinc uptake" EXACT [GOC:mah]
is_a: GO:0071577 ! zinc ion transmembrane transport

[Term]
id: GO:0071579
name: regulation of zinc ion transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:BHF, GOC:mah]
is_a: GO:0010959 ! regulation of metal ion transport
relationship: regulates GO:0006829 ! zinc ion transport

[Term]
id: GO:0071580
name: regulation of zinc ion transmembrane transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah]
is_a: GO:0034765 ! regulation of ion transmembrane transport
is_a: GO:0065007 ! biological regulation
is_a: GO:0071579 ! regulation of zinc ion transport
relationship: regulates GO:0071577 ! zinc ion transmembrane transport

[Term]
id: GO:0071581
name: regulation of zinc ion import
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah]
is_a: GO:0065007 ! biological regulation
is_a: GO:0071580 ! regulation of zinc ion transmembrane transport
relationship: regulates GO:0071578 ! zinc ion import

[Term]
id: GO:0071582
name: negative regulation of zinc ion transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:BHF, GOC:mah]
is_a: GO:0043271 ! negative regulation of ion transport
is_a: GO:0065007 ! biological regulation
is_a: GO:0071579 ! regulation of zinc ion transport
relationship: negatively_regulates GO:0006829 ! zinc ion transport

[Term]
id: GO:0071583
name: negative regulation of zinc ion transmembrane transport
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah]
is_a: GO:0034766 ! negative regulation of ion transmembrane transport
is_a: GO:0065007 ! biological regulation
is_a: GO:0071580 ! regulation of zinc ion transmembrane transport
is_a: GO:0071582 ! negative regulation of zinc ion transport
relationship: negatively_regulates GO:0071577 ! zinc ion transmembrane transport

[Term]
id: GO:0071584
name: negative regulation of zinc ion import
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah]
is_a: GO:0065007 ! biological regulation
is_a: GO:0071581 ! regulation of zinc ion import
is_a: GO:0071583 ! negative regulation of zinc ion transmembrane transport
relationship: negatively_regulates GO:0071578 ! zinc ion import

[Term]
id: GO:0071585
name: detoxification of cadmium ion
namespace: biological_process
def: "Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion." [GOC:BHF, PMID:16741752]
is_a: GO:0009636 ! response to toxin
is_a: GO:0046686 ! response to cadmium ion

[Term]
id: GO:0071586
name: CAAX-box protein processing
namespace: biological_process
def: "The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis." [GOC:mah]
is_a: GO:0051605 ! protein maturation by peptide bond cleavage
relationship: part_of GO:0080120 ! CAAX-box protein maturation

[Term]
id: GO:0071587
name: CAAX-box protein modification
namespace: biological_process
def: "The covalent alteration of one or more amino acid residues within the CAAX box region of CAAX box proteins." [GOC:mah]
is_a: GO:0043687 ! post-translational protein modification
relationship: part_of GO:0080120 ! CAAX-box protein maturation

[Term]
id: GO:0071588
name: hydrogen peroxide mediated signaling pathway
namespace: biological_process
def: "A series of molecular signals mediated by the detection of hydrogen peroxide (H2O2)." [GOC:mah, PMID:17043891]
synonym: "H2O2 mediated signaling pathway" EXACT [GOC:mah]
synonym: "hydrogen peroxide mediated signalling pathway" EXACT [GOC:mah]
is_a: GO:0007242 ! intracellular signaling cascade

[Term]
id: GO:0071589
name: pyridine nucleoside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of any pyridine nucleoside, one of a family of organic molecules consisting of a pyridine base covalently bonded to a sugar, usually ribose." [ChEBI:47896, GOC:mah]
subset: gosubset_prok
synonym: "pyridine nucleoside anabolism" EXACT [GOC:mah]
synonym: "pyridine nucleoside biosynthesis" EXACT [GOC:mah]
synonym: "pyridine nucleoside formation" EXACT [GOC:mah]
synonym: "pyridine nucleoside synthesis" EXACT [GOC:mah]
is_a: GO:0009163 ! nucleoside biosynthetic process
is_a: GO:0070637 ! pyridine nucleoside metabolic process

[Term]
id: GO:0071590
name: nicotinamide riboside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ChEBI:15927, GOC:mah, PMID:19846558]
synonym: "N-ribosylnicotinamide biosynthetic process" EXACT [ChEBI:15927]
synonym: "nicotinamide riboside anabolism" EXACT [GOC:mah]
synonym: "nicotinamide riboside biosynthesis" EXACT [GOC:mah]
synonym: "nicotinamide riboside formation" EXACT [GOC:mah]
synonym: "nicotinamide riboside synthesis" EXACT [GOC:mah]
is_a: GO:0046495 ! nicotinamide riboside metabolic process
is_a: GO:0071589 ! pyridine nucleoside biosynthetic process

[Term]
id: GO:0071591
name: nicotinic acid riboside metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid." [ChEBI:27748, GOC:mah, PMID:19846558]
synonym: "D-ribosylnicotinic acid metabolic process" EXACT [ChEBI:27748]
synonym: "nicotinic acid riboside metabolism" EXACT [GOC:mah]
is_a: GO:0070637 ! pyridine nucleoside metabolic process

[Term]
id: GO:0071592
name: nicotinic acid riboside biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid." [ChEBI:27748, GOC:mah, PMID:19846558]
synonym: "D-ribosylnicotinic acid biosynthetic process" EXACT [ChEBI:27748]
synonym: "nicotinic acid riboside anabolism" EXACT [GOC:mah]
synonym: "nicotinic acid riboside biosynthesis" EXACT [GOC:mah]
synonym: "nicotinic acid riboside formation" EXACT [GOC:mah]
synonym: "nicotinic acid riboside synthesis" EXACT [GOC:mah]
is_a: GO:0071589 ! pyridine nucleoside biosynthetic process
is_a: GO:0071591 ! nicotinic acid riboside metabolic process

[Term]
id: GO:0071593
name: lymphocyte aggregation
namespace: biological_process
def: "The adhesion of one lymphocyte to one or more other lymphocytes via adhesion molecules." [GOC:sl]
is_a: GO:0070486 ! leukocyte aggregation

[Term]
id: GO:0071594
name: thymocyte aggregation
namespace: biological_process
def: "The adhesion of one thymocyte (an immature T cell) to one or more other thymocytes via adhesion molecules." [GOC:sl, PMID:1382990]
synonym: "immature T cell aggregation" BROAD [CL:0000893, GOC:sl]
synonym: "immature T-cell aggregation" BROAD [CL:0000893, GOC:mah]
synonym: "immature T-lymphocyte aggregation" EXACT [CL:0000893, GOC:mah]
synonym: "T cell precursor aggregation" EXACT [GOC:sl]
synonym: "thymic lymphocyte aggregation" EXACT [GOC:sl]
is_a: GO:0071593 ! lymphocyte aggregation

[Term]
id: GO:0071595
name: Nem1-Spo7 phosphatase complex
namespace: cellular_component
def: "A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p." [GOC:mah, PMID:9822591]
is_a: GO:0008287 ! protein serine/threonine phosphatase complex
relationship: part_of GO:0042175 ! nuclear envelope-endoplasmic reticulum network

[Term]
id: GO:0071596
name: ubiquitin-dependent protein catabolic process via the N-end rule pathway
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation." [GOC:mah, GOC:rb, PMID:19246002, PMID:9112437]
synonym: "ubiquitin-dependent protein breakdown via the N-end rule pathway" EXACT [GOC:mah]
synonym: "ubiquitin-dependent protein catabolism via the N-end rule pathway" EXACT [GOC:mah]
synonym: "ubiquitin-dependent protein degradation via the N-end rule pathway" EXACT [GOC:mah]
is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process

[Term]
id: GO:0071597
name: cellular birth scar
namespace: cellular_component
def: "Crater-like ring of chitinous scar tissue located on the surface of the daughter cell, in budding fungi, at the site of separation from the mother cell. It is formed after the newly emerged daughter cell separates, thereby marking the site of cytokinesis and septation." [GOC:mcc, PMID:16672383, PMID:7730409]
is_a: GO:0044426 ! cell wall part
relationship: part_of GO:0009277 ! fungal-type cell wall

[Term]
id: GO:0071598
name: neuronal RNA granule
namespace: cellular_component
def: "A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli." [GOC:BHF, GOC:mah, PMID:19015237]
is_a: GO:0030529 ! ribonucleoprotein complex
relationship: part_of GO:0032838 ! cell projection cytoplasm
relationship: part_of GO:0043005 ! neuron projection

[Term]
id: GO:0071599
name: otic vesicle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:mah]
is_a: GO:0007423 ! sensory organ development
is_a: GO:0048839 ! inner ear development

[Term]
id: GO:0071600
name: otic vesicle morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the otic vesicle are generated and organized. Morphogenesis pertains to the creation of form. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:mah]
is_a: GO:0042472 ! inner ear morphogenesis
is_a: GO:0048562 ! embryonic organ morphogenesis
relationship: part_of GO:0071599 ! otic vesicle development

[Term]
id: GO:0071601
name: sphere organelle
namespace: cellular_component
def: "A nuclear body that is found in the germinal vesicles of amphibian oocytes, and consist of three major parts: a remarkably spherical body about 5-10 pm in diameter, smaller spherical or nearly spherical granules on the surface, and inclusions of various sizes that strongly resemble the surface granules. The parts of the sphere organelle have distinct compositions, including splicing snRNAs and proteins." [PMID:7758244, PMID:8349728]
is_a: GO:0016604 ! nuclear body

[Term]
id: GO:0071602
name: phytosphingosine biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol." [ChEBI:46961, GOC:mah]
synonym: "phytosphingosine anabolism" EXACT [GOC:mah]
synonym: "phytosphingosine biosynthesis" EXACT [GOC:mah]
synonym: "phytosphingosine formation" EXACT [GOC:mah]
synonym: "phytosphingosine synthesis" EXACT [GOC:mah]
is_a: GO:0006671 ! phytosphingosine metabolic process
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0046165 ! alcohol biosynthetic process
is_a: GO:0046520 ! sphingoid biosynthetic process

[Term]
id: GO:0071603
name: endothelial cell adhesion
namespace: biological_process
def: "The attachment of an endothelial cell to another endothelial cell via adhesion molecules." [GOC:BHF]
is_a: GO:0090136 ! epithelial cell adhesion

[Term]
id: GO:0071604
name: transforming growth factor-beta production
namespace: biological_process
def: "The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3." [GOC:add, GOC:rv]
synonym: "TGF-B production" EXACT [GOC:mah]
synonym: "TGF-beta production" EXACT [GOC:mah]
synonym: "TGFB production" EXACT [GOC:mah]
synonym: "TGFb production" EXACT [GOC:rv]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0071605
name: monocyte chemotactic protein-1 production
namespace: biological_process
def: "The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
synonym: "CCL2 production" EXACT [GOC:add, GOC:rv]
synonym: "MCP-1 production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071606
name: chemokine (C-C motif) ligand 4 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
synonym: "CCL4 production" EXACT [GOC:add, GOC:rv]
synonym: "macrophage inflammatory protein production" BROAD [GOC:add, GOC:rv]
synonym: "MIP-1b production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071607
name: macrophage inflammatory protein-1 gamma production
namespace: biological_process
def: "The appearance of macrophage inflammatory protein-1 gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
synonym: "CCL9 production" EXACT [GOC:add, GOC:rv]
synonym: "chemokine (C-C motif) ligand 9 production" EXACT [GOC:add, GOC:rv]
synonym: "MIP-1g production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071608
name: macrophage inflammatory protein-1 alpha production
namespace: biological_process
def: "The appearance of macrophage inflammatory protein 1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
synonym: "CCL3 production" EXACT [GOC:add, GOC:rv]
synonym: "chemokine (C-C motif) ligand 3 production" EXACT [GOC:add, GOC:rv]
synonym: "macrophage inflammatory protein production" BROAD [GOC:add, GOC:rv]
synonym: "MIP-1a production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071609
name: RANTES production
namespace: biological_process
def: "The appearance of the Regulated upon Activation, Normal T-cell Expressed, and Secreted protein (RANTES) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
synonym: "CCL5 production" EXACT [GOC:add, GOC:rv]
synonym: "chemokine (C-C motif) ligand 5 production" EXACT [GOC:add, GOC:rv]
synonym: "Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071610
name: chemokine (C-C motif) ligand 1 production
namespace: biological_process
def: "The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
synonym: "CCL1 production" EXACT [GOC:add, GOC:rv]
synonym: "T cell activation 3 production" EXACT [GOC:add, GOC:rv]
synonym: "TCA-3 production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071611
name: granulocyte colony stimulating factor production
namespace: biological_process
def: "The appearance of granulocyte colony stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
synonym: "colony stimulating factor 3 (granulocyte) production" EXACT [GOC:add]
synonym: "CSF3 production" EXACT [GOC:add]
synonym: "filgrastim production" EXACT [GOC:add]
synonym: "G-CSF production" EXACT [GOC:add]
synonym: "lenograstim production" EXACT [GOC:add]
synonym: "pluripoietin production" EXACT [GOC:add]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0071612
name: IP-10 production
namespace: biological_process
def: "The appearance of IP-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
synonym: "chemokine (C-C motif) ligand 10 production" EXACT [GOC:add, GOC:rv]
synonym: "CXCL10 production" EXACT [GOC:add, GOC:rv]
is_a: GO:0032602 ! chemokine production

[Term]
id: GO:0071613
name: granzyme B production
namespace: biological_process
def: "The appearance of granzyme B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv]
is_a: GO:0002440 ! production of molecular mediator of immune response

[Term]
id: GO:0071614
name: linoleic acid epoxygenase activity
namespace: molecular_function
def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts linoleic acid to a cis-epoxyoctadecenoic acid." [GOC:BHF, PMID:11042099]
synonym: "linoleic acid monooxygenase activity" EXACT [GOC:mah]
is_a: GO:0004497 ! monooxygenase activity
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0071615
name: oxidative deethylation
namespace: biological_process
def: "The process of removing one or more ethyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate." [GOC:BHF, GOC:mah, GOC:rl]
is_a: GO:0055114 ! oxidation reduction

[Term]
id: GO:0071616
name: acyl-CoA biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [GOC:cjk]
subset: gosubset_prok
synonym: "acyl-CoA anabolism" EXACT [GOC:mah]
synonym: "acyl-CoA biosynthesis" EXACT [GOC:mah]
synonym: "acyl-CoA formation" EXACT [GOC:mah]
synonym: "acyl-CoA synthesis" EXACT [GOC:mah]
is_a: GO:0006637 ! acyl-CoA metabolic process
is_a: GO:0009108 ! coenzyme biosynthetic process

[Term]
id: GO:0071617
name: lysophospholipid acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid." [GOC:cjk]
is_a: GO:0008415 ! acyltransferase activity

[Term]
id: GO:0071618
name: lysophosphatidylethanolamine acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine." [GOC:cjk]
is_a: GO:0071617 ! lysophospholipid acyltransferase activity

[Term]
id: GO:0071619
name: phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
namespace: biological_process
def: "The process of introducing a phosphate group onto a serine residue at position 2 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 2 (Ser2) occurs subsequent to phosphorylation of serine 5 and is thus seen in the middle and 3' ends of genes. In vivo, Ser5 phosphorylation is primarily performed by CTDK-I in S. cerevisiae or CDK9 in metazoans." [GOC:krc, PMID:17079683]
is_a: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain

[Term]
id: GO:0071620
name: phosphorylation of RNA polymerase II C-terminal domain serine 5 residues
namespace: biological_process
def: "The process of introducing a phosphate group onto a serine residue at position 5 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 5 (Ser5) occurs near the 5' ends of genes. It is generally still observed in the middle of genes, overlapping with phosphorylation of serine 2, but is generally not present at the 3' ends of genes. In vivo, Ser5 phosphorylation occurs primarily through the action of TFIIH (KIN28 in S. cerevisiae, CKD7 in metazoans)." [GOC:krc, PMID:17079683]
is_a: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain

[Term]
id: GO:0071621
name: granulocyte chemotaxis
namespace: biological_process
def: "The movement of a granulocyte in response to an external stimulus." [GOC:rph]
is_a: GO:0030595 ! leukocyte chemotaxis

[Term]
id: GO:0071622
name: regulation of granulocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
relationship: regulates GO:0071621 ! granulocyte chemotaxis

[Term]
id: GO:0071623
name: negative regulation of granulocyte chemotaxis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
relationship: negatively_regulates GO:0071621 ! granulocyte chemotaxis

[Term]
id: GO:0071624
name: positive regulation of granulocyte chemotaxis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0071622 ! regulation of granulocyte chemotaxis
relationship: positively_regulates GO:0071621 ! granulocyte chemotaxis

[Term]
id: GO:0071625
name: vocalization behavior
namespace: biological_process
def: "The behavior in which an organism produces sounds by a mechanism involving its respiratory system." [GOC:mah]
synonym: "vocalisation behaviour" EXACT [GOC:mah]
is_a: GO:0007610 ! behavior

[Term]
id: GO:0071626
name: mastication
namespace: biological_process
def: "The process of biting and mashing food with the teeth prior to swallowing." [GOC:gvg]
synonym: "chewing" EXACT [GOC:mah]
is_a: GO:0022600 ! digestive system process

[Term]
id: GO:0071627
name: integral to fungal-type vacuolar membrane
namespace: cellular_component
def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the fungal-type vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah]
is_a: GO:0031166 ! integral to vacuolar membrane
is_a: GO:0071628 ! intrinsic to fungal-type vacuolar membrane

[Term]
id: GO:0071628
name: intrinsic to fungal-type vacuolar membrane
namespace: cellular_component
def: "Located in the fungal-type vacuolar membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane." [GOC:mah]
is_a: GO:0031310 ! intrinsic to vacuolar membrane
relationship: part_of GO:0000329 ! fungal-type vacuole membrane

[Term]
id: GO:0071629
name: cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation." [GOC:mah, GOC:rb, PMID:20080635]
comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein breakdown" EXACT [GOC:mah]
synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein catabolism" EXACT [GOC:mah]
synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein degradation" EXACT [GOC:mah]
is_a: GO:0006515 ! misfolded or incompletely synthesized protein catabolic process
is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0071218 ! cellular response to misfolded protein

[Term]
id: GO:0071630
name: nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins via a mechanism in which the proteins are transported to the nucleus for ubiquitination, and then targeted to proteasomes for degradation." [GOC:mah, GOC:rb, PMID:20080635]
comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
synonym: "nucleus-associated proteasomal ubiquitin-dependent protein breakdown" EXACT [GOC:mah]
synonym: "nucleus-associated proteasomal ubiquitin-dependent protein catabolism" EXACT [GOC:mah]
synonym: "nucleus-associated proteasomal ubiquitin-dependent protein degradation" EXACT [GOC:mah]
is_a: GO:0006515 ! misfolded or incompletely synthesized protein catabolic process
is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process
is_a: GO:0071218 ! cellular response to misfolded protein

[Term]
id: GO:0071631
name: mating pheromone secretion
namespace: biological_process
def: "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells, from a cell." [GOC:mah]
synonym: "mating-type pheromone secretion" EXACT [GOC:vw]
is_a: GO:0030072 ! peptide hormone secretion
relationship: part_of GO:0000747 ! conjugation with cellular fusion

[Term]
id: GO:0071632
name: optomotor response
namespace: biological_process
def: "Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish." [GOC:dos, PMID:12726833, PMID:2469195]
xref: Wikipedia:Optomotor_response
is_a: GO:0007634 ! optokinetic behavior

[Term]
id: GO:0071633
name: dihydroceramidase activity
namespace: molecular_function
def: "Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine." [GOC:mah, PMID:10900202]
is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds
is_a: GO:0017040 ! ceramidase activity

[Term]
id: GO:0071634
name: regulation of transforming growth factor-beta production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah]
synonym: "regulation of TGF-B production" EXACT [GOC:mah]
synonym: "regulation of TGF-beta production" EXACT [GOC:mah]
synonym: "regulation of TGFB production" EXACT [GOC:mah]
synonym: "regulation of TGFb production" EXACT [GOC:mah]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0071604 ! transforming growth factor-beta production

[Term]
id: GO:0071635
name: negative regulation of transforming growth factor-beta production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah]
synonym: "negative regulation of TGF-B production" EXACT [GOC:mah]
synonym: "negative regulation of TGF-beta production" EXACT [GOC:mah]
synonym: "negative regulation of TGFB production" EXACT [GOC:mah]
synonym: "negative regulation of TGFb production" EXACT [GOC:mah]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0071634 ! regulation of transforming growth factor-beta production

[Term]
id: GO:0071636
name: positive regulation of transforming growth factor-beta production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah]
synonym: "positive regulation of TGF-B production" EXACT [GOC:mah]
synonym: "positive regulation of TGF-beta production" EXACT [GOC:mah]
synonym: "positive regulation of TGFB production" EXACT [GOC:mah]
synonym: "positive regulation of TGFb production" EXACT [GOC:mah]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0071634 ! regulation of transforming growth factor-beta production

[Term]
id: GO:0071637
name: regulation of monocyte chemotactic protein-1 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah]
synonym: "regulation of CCL2 production" EXACT [GOC:mah]
synonym: "regulation of MCP-1 production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production

[Term]
id: GO:0071638
name: negative regulation of monocyte chemotactic protein-1 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah]
synonym: "negative regulation of CCL2 production" EXACT [GOC:mah]
synonym: "negative regulation of MCP-1 production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071637 ! regulation of monocyte chemotactic protein-1 production

[Term]
id: GO:0071639
name: positive regulation of monocyte chemotactic protein-1 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah]
synonym: "positive regulation of CCL2 production" EXACT [GOC:mah]
synonym: "positive regulation of MCP-1 production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071637 ! regulation of monocyte chemotactic protein-1 production

[Term]
id: GO:0071640
name: regulation of macrophage inflammatory protein 1 alpha production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah]
synonym: "regulation of CCL3 production" EXACT [GOC:mah]
synonym: "regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah]
synonym: "regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "regulation of MIP-1a production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production

[Term]
id: GO:0071641
name: negative regulation of macrophage inflammatory protein 1 alpha production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah]
synonym: "negative regulation of CCL3 production" EXACT [GOC:mah]
synonym: "negative regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah]
synonym: "negative regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "negative regulation of MIP-1a production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071640 ! regulation of macrophage inflammatory protein 1 alpha production
relationship: negatively_regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production

[Term]
id: GO:0071642
name: positive regulation of macrophage inflammatory protein 1 alpha production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah]
synonym: "positive regulation of CCL3 production" EXACT [GOC:mah]
synonym: "positive regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah]
synonym: "positive regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "positive regulation of MIP-1a production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071640 ! regulation of macrophage inflammatory protein 1 alpha production
relationship: positively_regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production

[Term]
id: GO:0071643
name: regulation of chemokine (C-C motif) ligand 4 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah]
synonym: "regulation of CCL4 production" EXACT [GOC:mah]
synonym: "regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "regulation of MIP-1b production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production

[Term]
id: GO:0071644
name: negative regulation of chemokine (C-C motif) ligand 4 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah]
synonym: "negative regulation of CCL4 production" EXACT [GOC:mah]
synonym: "negative regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "negative regulation of MIP-1b production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071643 ! regulation of chemokine (C-C motif) ligand 4 production
relationship: negatively_regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production

[Term]
id: GO:0071645
name: positive regulation of chemokine (C-C motif) ligand 4 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah]
synonym: "positive regulation of CCL4 production" EXACT [GOC:mah]
synonym: "positive regulation of macrophage inflammatory protein production" BROAD [GOC:mah]
synonym: "positive regulation of MIP-1b production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071643 ! regulation of chemokine (C-C motif) ligand 4 production
relationship: positively_regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production

[Term]
id: GO:0071646
name: regulation of macrophage inflammatory protein-1 gamma production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah]
synonym: "regulation of CCL9 production" EXACT [GOC:mah]
synonym: "regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah]
synonym: "regulation of MIP-1g production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production

[Term]
id: GO:0071647
name: negative regulation of macrophage inflammatory protein-1 gamma production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah]
synonym: "negative regulation of CCL9 production" EXACT [GOC:mah]
synonym: "negative regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah]
synonym: "negative regulation of MIP-1g production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071646 ! regulation of macrophage inflammatory protein-1 gamma production
relationship: negatively_regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production

[Term]
id: GO:0071648
name: positive regulation of macrophage inflammatory protein-1 gamma production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah]
synonym: "positive regulation of CCL9 production" EXACT [GOC:mah]
synonym: "positive regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah]
synonym: "positive regulation of MIP-1g production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071646 ! regulation of macrophage inflammatory protein-1 gamma production
relationship: positively_regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production

[Term]
id: GO:0071649
name: regulation of RANTES production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of RANTES." [GOC:mah]
synonym: "regulation of CCL5 production" EXACT [GOC:mah]
synonym: "regulation of chemokine (C-C motif) ligand 5 production" EXACT [GOC:mah]
synonym: "regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0071609 ! RANTES production

[Term]
id: GO:0071650
name: negative regulation of RANTES production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of RANTES." [GOC:mah]
synonym: "negative regulation of CCL5 production" EXACT [GOC:mah]
synonym: "negative regulation of chemokine (C-C motif) ligand 5 production" EXACT [GOC:mah]
synonym: "negative regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071649 ! regulation of RANTES production
relationship: negatively_regulates GO:0071609 ! RANTES production

[Term]
id: GO:0071651
name: positive regulation of RANTES production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of RANTES." [GOC:mah]
synonym: "positive regulation of CCL5 production" EXACT [GOC:mah]
synonym: "positive regulation of chemokine (C-C motif) ligand 5 production" EXACT [GOC:mah]
synonym: "positive regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071649 ! regulation of RANTES production
relationship: positively_regulates GO:0071609 ! RANTES production

[Term]
id: GO:0071652
name: regulation of chemokine (C-C motif) ligand 1 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah]
synonym: "regulation of CCL1 production" EXACT [GOC:mah]
synonym: "regulation of T cell activation 3 production" EXACT [GOC:mah]
synonym: "regulation of TCA-3 production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production

[Term]
id: GO:0071653
name: negative regulation of chemokine (C-C motif) ligand 1 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah]
synonym: "negative regulation of CCL1 production" EXACT [GOC:mah]
synonym: "negative regulation of T cell activation 3 production" EXACT [GOC:mah]
synonym: "negative regulation of TCA-3 production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071652 ! regulation of chemokine (C-C motif) ligand 1 production
relationship: negatively_regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production

[Term]
id: GO:0071654
name: positive regulation of chemokine (C-C motif) ligand 1 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah]
synonym: "positive regulation of CCL1 production" EXACT [GOC:mah]
synonym: "positive regulation of T cell activation 3 production" EXACT [GOC:mah]
synonym: "positive regulation of TCA-3 production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071652 ! regulation of chemokine (C-C motif) ligand 1 production
relationship: positively_regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production

[Term]
id: GO:0071655
name: regulation of granulocyte colony stimulating factor production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of granulocyte colony stimulating factor." [GOC:mah]
synonym: "regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah]
synonym: "regulation of CSF3 production" EXACT [GOC:mah]
synonym: "regulation of filgrastim production" EXACT [GOC:mah]
synonym: "regulation of G-CSF production" EXACT [GOC:mah]
synonym: "regulation of lenograstim production" EXACT [GOC:mah]
synonym: "regulation of pluripoietin production" EXACT [GOC:mah]
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0071611 ! granulocyte colony stimulating factor production

[Term]
id: GO:0071656
name: negative regulation of granulocyte colony stimulating factor production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granulocyte colony stimulating factor." [GOC:mah]
synonym: "negative regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah]
synonym: "negative regulation of CSF3 production" EXACT [GOC:mah]
synonym: "negative regulation of filgrastim production" EXACT [GOC:mah]
synonym: "negative regulation of G-CSF production" EXACT [GOC:mah]
synonym: "negative regulation of lenograstim production" EXACT [GOC:mah]
synonym: "negative regulation of pluripoietin production" EXACT [GOC:mah]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0071655 ! regulation of granulocyte colony stimulating factor production
relationship: negatively_regulates GO:0071611 ! granulocyte colony stimulating factor production

[Term]
id: GO:0071657
name: positive regulation of granulocyte colony stimulating factor production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of granulocyte colony stimulating factor." [GOC:mah]
synonym: "positive regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah]
synonym: "positive regulation of CSF3 production" EXACT [GOC:mah]
synonym: "positive regulation of filgrastim production" EXACT [GOC:mah]
synonym: "positive regulation of G-CSF production" EXACT [GOC:mah]
synonym: "positive regulation of lenograstim production" EXACT [GOC:mah]
synonym: "positive regulation of pluripoietin production" EXACT [GOC:mah]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0071655 ! regulation of granulocyte colony stimulating factor production
relationship: positively_regulates GO:0071611 ! granulocyte colony stimulating factor production

[Term]
id: GO:0071658
name: regulation of IP-10 production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of IP-10." [GOC:mah]
synonym: "regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah]
synonym: "regulation of CXCL10 production" EXACT [GOC:mah]
is_a: GO:0032642 ! regulation of chemokine production
relationship: regulates GO:0071612 ! IP-10 production

[Term]
id: GO:0071659
name: negative regulation of IP-10 production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of IP-10." [GOC:mah]
synonym: "negative regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah]
synonym: "negative regulation of CXCL10 production" EXACT [GOC:mah]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0071658 ! regulation of IP-10 production
relationship: negatively_regulates GO:0071612 ! IP-10 production

[Term]
id: GO:0071660
name: positive regulation of IP-10 production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of IP-10." [GOC:mah]
synonym: "positive regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah]
synonym: "positive regulation of CXCL10 production" EXACT [GOC:mah]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0071658 ! regulation of IP-10 production
relationship: positively_regulates GO:0071612 ! IP-10 production

[Term]
id: GO:0071661
name: regulation of granzyme B production
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of production of granzyme B." [GOC:mah]
is_a: GO:0001817 ! regulation of cytokine production
is_a: GO:0002700 ! regulation of production of molecular mediator of immune response

[Term]
id: GO:0071662
name: negative regulation of granzyme B production
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granzyme B." [GOC:mah]
is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response
is_a: GO:0071661 ! regulation of granzyme B production

[Term]
id: GO:0071663
name: positive regulation of granzyme B production
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of production of granzyme B." [GOC:mah]
is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response
is_a: GO:0071661 ! regulation of granzyme B production

[Term]
id: GO:0071664
name: catenin-TCF7L2 complex
namespace: cellular_component
def: "A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:vk, PMID:14661054]
subset: gosubset_prok
synonym: "catenin-TCF4 complex" EXACT [GOC:mah]
is_a: GO:0043234 ! protein complex
is_a: GO:0044445 ! cytosolic part

[Term]
id: GO:0071665
name: gamma-catenin-TCF7L2 complex
namespace: cellular_component
def: "A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:vk, PMID:14661054]
subset: gosubset_prok
synonym: "gamma-catenin-TCF4 complex" EXACT [GOC:mah]
synonym: "plakoglobin-TCF4 complex" EXACT [PMID:14661054]
is_a: GO:0071664 ! catenin-TCF7L2 complex

[Term]
id: GO:0071666
name: Slit-Robo signaling complex
namespace: cellular_component
def: "A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate." [GOC:sart, PMID:17062560, PMID:18359766]
is_a: GO:0032992 ! protein-carbohydrate complex

[Term]
id: GO:0071667
name: DNA/RNA hybrid binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with a RNA/DNA hybrid." [GOC:ecd]
synonym: "RNA/DNA hybrid binding" EXACT [GOC:ecd]
is_a: GO:0003676 ! nucleic acid binding

[Term]
id: GO:0071668
name: plant-type cell wall assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a cellulose- and pectin-containing cell wall." [GOC:mah]
is_a: GO:0009664 ! plant-type cell wall organization
is_a: GO:0070726 ! cell wall assembly
relationship: part_of GO:0009832 ! plant-type cell wall biogenesis

[Term]
id: GO:0071669
name: plant-type cell wall organization or biogenesis
namespace: biological_process
def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall." [GOC:ecd, GOC:mah]
synonym: "plant-type cell wall organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0071554 ! cell wall organization or biogenesis

[Term]
id: GO:0071670
name: smooth muscle cell chemotaxis
namespace: biological_process
def: "The directed movement of a smooth muscle cell in response to an external stimulus." [GOC:mah]
is_a: GO:0014909 ! smooth muscle cell migration
is_a: GO:0060326 ! cell chemotaxis

[Term]
id: GO:0071671
name: regulation of smooth muscle cell chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah]
is_a: GO:0014910 ! regulation of smooth muscle cell migration
is_a: GO:0050920 ! regulation of chemotaxis
relationship: regulates GO:0071670 ! smooth muscle cell chemotaxis

[Term]
id: GO:0071672
name: negative regulation of smooth muscle cell chemotaxis
namespace: biological_process
def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah]
synonym: "down regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "down-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "downregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "inhibition of smooth muscle cell chemotaxis" NARROW [GOC:mah]
is_a: GO:0014912 ! negative regulation of smooth muscle cell migration
is_a: GO:0050922 ! negative regulation of chemotaxis
is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis
relationship: negatively_regulates GO:0071670 ! smooth muscle cell chemotaxis

[Term]
id: GO:0071673
name: positive regulation of smooth muscle cell chemotaxis
namespace: biological_process
def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah]
synonym: "activation of smooth muscle cell chemotaxis" NARROW [GOC:mah]
synonym: "stimulation of smooth muscle cell chemotaxis" NARROW [GOC:mah]
synonym: "up regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "up-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
synonym: "upregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah]
is_a: GO:0014911 ! positive regulation of smooth muscle cell migration
is_a: GO:0050921 ! positive regulation of chemotaxis
is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis
relationship: positively_regulates GO:0071670 ! smooth muscle cell chemotaxis

[Term]
id: GO:0071674
name: mononuclear cell migration
namespace: biological_process
def: "The movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
is_a: GO:0050900 ! leukocyte migration

[Term]
id: GO:0071675
name: regulation of mononuclear cell migration
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
is_a: GO:0002685 ! regulation of leukocyte migration
relationship: regulates GO:0071674 ! mononuclear cell migration

[Term]
id: GO:0071676
name: negative regulation of mononuclear cell migration
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
synonym: "down regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "down-regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "downregulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "inhibition of mononuclear cell migration" NARROW [GOC:mah]
is_a: GO:0002686 ! negative regulation of leukocyte migration
is_a: GO:0071675 ! regulation of mononuclear cell migration
relationship: negatively_regulates GO:0071674 ! mononuclear cell migration

[Term]
id: GO:0071677
name: positive regulation of mononuclear cell migration
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah]
synonym: "activation of mononuclear cell migration" NARROW [GOC:mah]
synonym: "stimulation of mononuclear cell migration" NARROW [GOC:mah]
synonym: "up regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "up-regulation of mononuclear cell migration" EXACT [GOC:mah]
synonym: "upregulation of mononuclear cell migration" EXACT [GOC:mah]
is_a: GO:0002687 ! positive regulation of leukocyte migration
is_a: GO:0071675 ! regulation of mononuclear cell migration
relationship: positively_regulates GO:0071674 ! mononuclear cell migration

[Term]
id: GO:0071678
name: olfactory bulb axon guidance
namespace: biological_process
def: "The process by which the migration of an axon growth cone of a neuron in the olfactory bulb is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]
synonym: "olfactory bulb axon pathfinding" EXACT [GOC:vk]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0071679
name: commissural neuron axon guidance
namespace: biological_process
def: "The process by which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah]
synonym: "commissural neuron axon pathfinding" EXACT [GOC:vk]
is_a: GO:0007411 ! axon guidance

[Term]
id: GO:0071680
name: response to indole-3-methanol
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [ChEBI:24814, GOC:mah]
synonym: "response to indole-3-carbinol" EXACT [ChEBI:24814]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0071681
name: cellular response to indole-3-methanol
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [ChEBI:24814, GOC:mah]
synonym: "cellular response to indole-3-carbinol" EXACT [ChEBI:24814]
is_a: GO:0071310 ! cellular response to organic substance
is_a: GO:0071680 ! response to indole-3-methanol

[Term]
id: GO:0071682
name: endocytic vesicle lumen
namespace: cellular_component
def: "The volume enclosed by the membrane of an endocytic vesicle." [GOC:pde]
is_a: GO:0060205 ! cytoplasmic membrane-bounded vesicle lumen
relationship: part_of GO:0030139 ! endocytic vesicle

[Term]
id: GO:0071683
name: sensory dendrite
namespace: cellular_component
def: "A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron." [GOC:dos, GOC:kmv, GOC:mah]
is_a: GO:0030425 ! dendrite

[Term]
id: GO:0071684
name: organism emergence from protective structure
namespace: biological_process
def: "The developmental process by which an organism emerges from a surrounding protective structure such as an egg or pupa case." [GOC:mah]
is_a: GO:0032502 ! developmental process

[Term]
id: GO:0071685
name: NADH dehydrogenase complex (plastoquinone)
namespace: cellular_component
def: "An NADH dehydrogenase complex that catalyzes the transfer of electrons to plastoquinone. The complex is involved in the non-photochemical reduction of plastoquinones and the cyclic electron transport around photosystem I, and is found in plastid thylakoids." [DOI:10.1078/0176-1617-00593, GOC:mah]
is_a: GO:0030964 ! NADH dehydrogenase complex
relationship: part_of GO:0031976 ! plastid thylakoid

[Term]
id: GO:0071686
name: horsetail nucleus
namespace: cellular_component
def: "The elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe." [GOC:vw, PMID:15030757]
is_a: GO:0005634 ! nucleus

[Term]
id: GO:0071687
name: horsetail nucleus leading edge
namespace: cellular_component
def: "The part of the horsetail nucleus where telomeres cluster under the SPB and that leads horsetail movement. The horsetail nucleus is the elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe." [GOC:mah, GOC:vw, PMID:15030757]
is_a: GO:0044428 ! nuclear part
relationship: part_of GO:0071686 ! horsetail nucleus

[Term]
id: GO:0071688
name: muscle thick filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle." [GOC:mah]
is_a: GO:0031034 ! myosin filament assembly
relationship: part_of GO:0030239 ! myofibril assembly

[Term]
id: GO:0071689
name: muscle thin filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in striated muscle." [GOC:mah]
is_a: GO:0007015 ! actin filament organization
relationship: part_of GO:0030239 ! myofibril assembly

[Term]
id: GO:0071690
name: cardiac muscle thick filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in cardiac muscle." [GOC:mah]
is_a: GO:0031034 ! myosin filament assembly
relationship: part_of GO:0055003 ! cardiac myofibril assembly

[Term]
id: GO:0071691
name: cardiac muscle thin filament assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in cardiac muscle." [GOC:mah]
is_a: GO:0007015 ! actin filament organization
relationship: part_of GO:0055003 ! cardiac myofibril assembly

[Term]
id: GO:0071692
name: protein localization in extracellular region
namespace: biological_process
def: "Any process by which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." [GOC:mah]
is_a: GO:0008104 ! protein localization

[Term]
id: GO:0071693
name: protein transport in within extracellular region
namespace: biological_process
def: "The directed movement of proteins in the extracellular region." [GOC:mah]
is_a: GO:0015031 ! protein transport
relationship: part_of GO:0071692 ! protein localization in extracellular region

[Term]
id: GO:0071694
name: maintenance of protein location in extracellular region
namespace: biological_process
def: "Any process by which a protein is maintained in a specific location within the extracellular region and is prevented from moving elsewhere." [GOC:mah]
is_a: GO:0045185 ! maintenance of protein location
relationship: part_of GO:0071692 ! protein localization in extracellular region

[Term]
id: GO:0072001
name: renal system development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products." [GOC:mtg_kidney_jan10]
is_a: GO:0048731 ! system development
relationship: part_of GO:0001655 ! urogenital system development

[Term]
id: GO:0072002
name: Malpighian tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the Malpighian tubule over time, from its formation to the mature structure. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:mtg_kidney_jan10]
is_a: GO:0048513 ! organ development
relationship: part_of GO:0072001 ! renal system development

[Term]
id: GO:0072003
name: kidney rudiment formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a kidney rudiment from unspecified parts. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10]
synonym: "kidney anlage formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060993 ! kidney morphogenesis

[Term]
id: GO:0072004
name: kidney field specification
namespace: biological_process
def: "The process by which regions of the embryo are delineated into the area in which the kidney rudiment will develop." [GOC:mtg_kidney_jan10]
synonym: "specification of kidney anlage" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0010092 ! specification of organ identity
relationship: part_of GO:0072003 ! kidney rudiment formation

[Term]
id: GO:0072005
name: maintenance of kidney identity
namespace: biological_process
def: "The process by which the identity of a kidney is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10]
synonym: "maintenance of kidney anlage identity" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0048496 ! maintenance of organ identity
relationship: part_of GO:0072003 ! kidney rudiment formation

[Term]
id: GO:0072006
name: nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072007
name: mesangial cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0001822 ! kidney development
is_a: GO:0061005 ! cell differentiation involved in kidney development

[Term]
id: GO:0072008
name: glomerular mesangial cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0072007 ! mesangial cell differentiation
relationship: part_of GO:0072109 ! glomerular mesangium development

[Term]
id: GO:0072009
name: nephron epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
relationship: part_of GO:0072006 ! nephron development

[Term]
id: GO:0072010
name: glomerular epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
relationship: part_of GO:0032835 ! glomerulus development

[Term]
id: GO:0072011
name: glomerular endothelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the glomerular endothelium over time, from its formation to the mature structure. The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
relationship: part_of GO:0072012 ! glomerulus vasculature development

[Term]
id: GO:0072012
name: glomerulus vasculature development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the glomerulus vasculature and ends with the mature structure. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." [GOC:mtg_kidney_jan10]
synonym: "glomerulus capillary development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0001568 ! blood vessel development
relationship: part_of GO:0032835 ! glomerulus development

[Term]
id: GO:0072013
name: glomus development
namespace: biological_process
def: "The progression of the glomus over time from its initial formation until its mature state. The glomus is the vascular component of the pronephros and filters waste from the blood before it enters the pronephric tubules." [GOC:mtg_kidney_jan10, PMID:10572058]
is_a: GO:0032835 ! glomerulus development
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0072014
name: proximal tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the proximal tubule over time, from its formation to the mature structure. The proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development

[Term]
id: GO:0072015
name: glomerular visceral epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:mtg_kidney_jan10]
synonym: "podocyte development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0072112 ! glomerular visceral epithelial cell differentiation

[Term]
id: GO:0072016
name: glomerular parietal epithelial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glomerular parietal epithelial cell over time, from its formation to the mature structure. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10]
synonym: "Bowman's capsule development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0002064 ! epithelial cell development
relationship: part_of GO:0072010 ! glomerular epithelium development
relationship: part_of GO:0072139 ! glomerular parietal epithelial cell differentiation

[Term]
id: GO:0072017
name: distal tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. The distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development

[Term]
id: GO:0072019
name: proximal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the proximal convoluted tubule over time, from its formation to the mature structure. The proximal convoluted tubule is the most proximal portion of the proximal tubule and extends from the glomerular capsule to the proximal straight tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072014 ! proximal tubule development

[Term]
id: GO:0072020
name: proximal straight tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the proximal straight tubule over time, from its formation to the mature structure. The proximal straight tubule is the part of the descending limb that extends from the proximal convoluted tubule to the descending thin tubule." [GOC:mtg_kidney_jan10]
synonym: "S3 development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072014 ! proximal tubule development

[Term]
id: GO:0072021
name: ascending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of an ascending thin limb over time, from its formation to the mature structure. The ascending thin limb is a segment of a nephron tubule lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072070 ! loop of Henle development

[Term]
id: GO:0072022
name: descending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the descending thin limb over time, from its formation to the mature structure. The descending thin limb is a part of the loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the loop of Henle." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072070 ! loop of Henle development

[Term]
id: GO:0072023
name: thick ascending limb development
namespace: biological_process
alt_id: GO:0072026
def: "The process whose specific outcome is the progression of the thick ascending limb over time, from its formation to the mature structure. The thick ascending limb is the last part of the loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule." [GOC:mtg_kidney_jan10]
synonym: "TAL development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072017 ! distal tubule development

[Term]
id: GO:0072024
name: macula densa development
namespace: biological_process
def: "The process whose specific outcome is the progression of the macula densa over time, from its formation to the mature structure. The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072006 ! nephron development
relationship: part_of GO:0072051 ! juxtaglomerular apparatus development

[Term]
id: GO:0072025
name: distal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the distal convoluted tubule over time, from its formation to the mature structure. The distal convoluted tubule is a portion of the nephron tubule that connects the loop of Henle to the collecting duct." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072017 ! distal tubule development

[Term]
id: GO:0072027
name: connecting tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the connecting tubule over time, from its formation to the mature structure. The connecting tubule is a tubular segment of the nephron; it connects the distal convoluted tubule to the collecting duct." [GOC:mtg_kidney_jan10]
synonym: "connecting duct development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development

[Term]
id: GO:0072028
name: nephron morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the nephron are generated and organized. Morphogenesis pertains to the creation of form. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0060993 ! kidney morphogenesis
relationship: part_of GO:0072006 ! nephron development

[Term]
id: GO:0072029
name: long nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla." [GOC:mtg_kidney_jan10]
synonym: "juxtamedullary nephron development" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072006 ! nephron development

[Term]
id: GO:0072030
name: short nephron development
namespace: biological_process
def: "The process whose specific outcome is the progression of a short nephron over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb." [GOC:mtg_kidney_jan10]
is_a: GO:0072006 ! nephron development

[Term]
id: GO:0072031
name: S1 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the S1 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the proximal convoluted tubule and is responsible for avid reabsorption of water and solutes." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072019 ! proximal convoluted tubule development

[Term]
id: GO:0072032
name: S2 development
namespace: biological_process
def: "The process whose specific outcome is the progression of the S2 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the tubule is involved in reabsorption of water and sodium chloride." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072019 ! proximal convoluted tubule development

[Term]
id: GO:0072033
name: renal vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the renal vesicle from condensed mesenchymal cells. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
synonym: "nephron epithelium formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0072077 ! renal vesicle morphogenesis

[Term]
id: GO:0072034
name: positive regulation of renal vesicle formation
namespace: biological_process
def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the renal vesicle." [GOC:mtg_kidney_jan10]
synonym: "nephron induction" EXACT [GOC:mtg_kidney_jan10]
synonym: "positive regulation of nephron formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0031128 ! developmental induction
is_a: GO:0090184 ! positive regulation of kidney development
relationship: positively_regulates GO:0072033 ! renal vesicle formation

[Term]
id: GO:0072035
name: pre-tubular aggregate formation
namespace: biological_process
def: "The cell adhesion process by which mammary mesenchyme cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney." [GOC:mtg_kidney_jan10]
synonym: "mesenchymal cell condensation involved in renal vesicle formation" EXACT [GOC:mtg_kidney_jan10]
synonym: "nephron epithelium formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0072033 ! renal vesicle formation

[Term]
id: GO:0072036
name: mesenchymal to epithelial transition involved in renal vesicle formation
namespace: biological_process
def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the renal vesicle." [GOC:mtg_kidney_jan10]
is_a: GO:0060231 ! mesenchymal to epithelial transition
relationship: part_of GO:0072033 ! renal vesicle formation

[Term]
id: GO:0072037
name: mesenchymal stem cell differentiation involved in nephron morphogenesis
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0048863 ! stem cell differentiation
relationship: part_of GO:0072028 ! nephron morphogenesis

[Term]
id: GO:0072038
name: mesenchymal stem cell maintenance involved in nephron morphogenesis
namespace: biological_process
def: "The process by which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0035019 ! somatic stem cell maintenance
relationship: part_of GO:0072028 ! nephron morphogenesis

[Term]
id: GO:0072039
name: regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis
namespace: biological_process
def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptosis that contributes to the shaping of the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0042981 ! regulation of apoptosis
is_a: GO:0060284 ! regulation of cell development
is_a: GO:0090183 ! regulation of kidney development
relationship: regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis

[Term]
id: GO:0072040
name: negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis
namespace: biological_process
def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptosis that contributes to the shaping of the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0043066 ! negative regulation of apoptosis
is_a: GO:0072039 ! regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis
relationship: negatively_regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis

[Term]
id: GO:0072041
name: positive regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis
namespace: biological_process
def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptosis that contributes to the shaping of the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0043065 ! positive regulation of apoptosis
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0072039 ! regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis
relationship: positively_regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis

[Term]
id: GO:0072042
name: regulation of mesenchymal stem cell proliferation involved in nephron morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell proliferation and contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0072091 ! regulation of stem cell proliferation
relationship: regulates GO:0072090 ! mesenchymal stem cell proliferation involved in nephron morphogenesis

[Term]
id: GO:0072043
name: regulation of pre-tubular aggregate formation by cell-cell signaling
namespace: biological_process
def: "Any process that mediates the transfer of information from one cell to another that modulates the rate, frequency, or extent of pre-tubular aggregate formation. Pre-tubular aggregate formation is the cell adhesion process by which mammary mesenchyme cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0007267 ! cell-cell signaling
is_a: GO:0022407 ! regulation of cell-cell adhesion
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0090183 ! regulation of kidney development
relationship: regulates GO:0072035 ! pre-tubular aggregate formation

[Term]
id: GO:0072044
name: collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072045
name: convergent extension involved in nephron morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0060026 ! convergent extension
relationship: part_of GO:0072028 ! nephron morphogenesis

[Term]
id: GO:0072046
name: establishment of planar polarity involved in nephron morphogenesis
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10]
synonym: "establishment of planar cell polarity involved in nephron morphogenesis" NARROW [GOC:mtg_kidney_jan10]
is_a: GO:0001736 ! establishment of planar polarity
relationship: part_of GO:0072028 ! nephron morphogenesis

[Term]
id: GO:0072047
name: proximal/distal pattern formation involved in nephron development
namespace: biological_process
def: "The regionalization process by which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end)." [GOC:mtg_kidney_jan10]
synonym: "proximal-distal pattern formation involved in nephron development" EXACT [GOC:mtg_kidney_jan10]
synonym: "proximal/distal nephron patterning" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0009954 ! proximal/distal pattern formation
is_a: GO:0061004 ! pattern specification involved in kidney development
relationship: part_of GO:0072006 ! nephron development

[Term]
id: GO:0072048
name: renal system pattern specification
namespace: biological_process
def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate into the anatomical structures of the renal system." [GOC:mtg_kidney_jan10]
synonym: "renal system pattern formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0072001 ! renal system development

[Term]
id: GO:0072049
name: comma-shaped body morphogenesis
namespace: biological_process
def: "The process by which the comma-shaped body is generated and organized. Morphogenesis pertains to the creation of form. The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0072028 ! nephron morphogenesis

[Term]
id: GO:0072050
name: S-shaped body morphogenesis
namespace: biological_process
def: "The process by which the S-shaped body is generated and organized. Morphogenesis pertains to the creation of form. The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0072028 ! nephron morphogenesis

[Term]
id: GO:0072051
name: juxtaglomerular apparatus development
namespace: biological_process
def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure that lies adjacent to the glomerulus and regulates kidney function." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072052
name: juxtaglomerulus cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072051 ! juxtaglomerular apparatus development

[Term]
id: GO:0072053
name: renal inner medulla development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal inner medulla over time, from its formation to the mature structure. The renal inner medulla is unique to mammalian kidneys and is the innermost region of the mammalian kidney." [GOC:mtg_kidney_jan10]
synonym: "inner renal medulla development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072054
name: renal outer medulla development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal outer medulla over time, from its formation to the mature structure. The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla." [GOC:mtg_kidney_jan10]
synonym: "outer renal medulla development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072055
name: renal cortex development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal cortex over time, from its formation to the mature structure. The renal cortex is the outer region of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072056
name: pyramids development
namespace: biological_process
def: "The process whose specific outcome is the progression of the kidney pyramids over time, from its formation to the mature structure. Kidney pyramids are the conical masses that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072057
name: inner stripe development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inner stripe over time, from its formation to the mature structure. The inner stripe is a deep, centrally located portion of the renal outer medulla and is traversed by thin descending and thick ascending portions of the loops of Henle." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072054 ! renal outer medulla development

[Term]
id: GO:0072058
name: outer stripe development
namespace: biological_process
def: "The process whose specific outcome is the progression of the outer stripe over time, from its formation to the mature structure. The outer stripe is the region of the kidney outer medulla that lies just below the cortex. The proximal straight tubules (S3) characterize this region." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072054 ! renal outer medulla development

[Term]
id: GO:0072059
name: cortical collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the cortical collecting duct over time, from its formation to the mature structure. The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072044 ! collecting duct development

[Term]
id: GO:0072060
name: outer medullary collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the outer medullary collecting duct over time, from its formation to the mature structure. The outer medullary collecting duct is the portion of the collecting duct that lies in the renal outer medulla." [GOC:mtg_kidney_jan10]
is_a: GO:0072044 ! collecting duct development

[Term]
id: GO:0072061
name: inner medullary collecting duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of the inner medullary collecting duct over time, from its formation to the mature structure. The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla." [GOC:mtg_kidney_jan10]
is_a: GO:0072044 ! collecting duct development

[Term]
id: GO:0072062
name: S1 cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the S1 cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072031 ! S1 development

[Term]
id: GO:0072063
name: short descending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the short descending thin limb over time, from its formation to the mature structure. The short descending thin limb is the descending thin limb of a short nephron that has a squamous epithelial morphology." [GOC:mtg_kidney_jan10]
is_a: GO:0072022 ! descending thin limb development
relationship: part_of GO:0072030 ! short nephron development

[Term]
id: GO:0072064
name: long descending thin limb development
namespace: biological_process
def: "The process whose specific outcome is the progression of the long descending thin limb over time, from its formation to the mature structure. The long descending thin limb is the descending thin limb of a long nephron that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla." [GOC:mtg_kidney_jan10]
is_a: GO:0072022 ! descending thin limb development
relationship: part_of GO:0072029 ! long nephron development

[Term]
id: GO:0072065
name: long descending thin limb bend development
namespace: biological_process
def: "The process whose specific outcome is the progression of the long descending thin limb bend over time, from its formation to the mature structure. The long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072022 ! descending thin limb development
relationship: part_of GO:0072029 ! long nephron development

[Term]
id: GO:0072066
name: prebend segment development
namespace: biological_process
def: "The process whose specific outcome is the progression of the prebend segment over time, from its formation to the mature structure. The prebend segment is a part of the descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072022 ! descending thin limb development

[Term]
id: GO:0072067
name: early distal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the early distal convoluted tubule over time, from its formation to the mature structure. The early distal convoluted tubule contains DCT cells and is vasopressin-insensitive." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072025 ! distal convoluted tubule development

[Term]
id: GO:0072068
name: late distal convoluted tubule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the late distal convoluted tubule over time, from its formation to the mature structure. The late distal convoluted tubule contains DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072025 ! distal convoluted tubule development

[Term]
id: GO:0072069
name: DCT cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
synonym: "distal convoluted tubule cell differentiation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072025 ! distal convoluted tubule development

[Term]
id: GO:0072070
name: loop of Henle development
namespace: biological_process
alt_id: GO:0072018
def: "The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule." [GOC:mtg_kidney_jan10]
synonym: "intermediate tubule development" EXACT []
is_a: GO:0072080 ! nephron tubule development

[Term]
id: GO:0072071
name: renal interstitial cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
synonym: "kidney interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development

[Term]
id: GO:0072072
name: kidney stroma development
namespace: biological_process
def: "The process whose specific outcome is the progression of the kidney stroma over time, from its formation to the mature structure. The kidney stroma is the mesenchyme of the mature kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0072074 ! kidney mesenchyme development

[Term]
id: GO:0072073
name: kidney epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10]
is_a: GO:0060429 ! epithelium development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072074
name: kidney mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0060485 ! mesenchyme development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072075
name: metanephric mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072074 ! kidney mesenchyme development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0072076
name: nephrogenic mesenchyme development
namespace: biological_process
def: "The biological process whose specific outcome is the progression of a nephrogenic mesenchyme from an initial condition to its mature state. This process begins with the formation of nephrogenic mesenchyme and ends with the mature structure. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0072074 ! kidney mesenchyme development
relationship: part_of GO:0072006 ! nephron development

[Term]
id: GO:0072077
name: renal vesicle morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the renal vesicle are generated and organized. Morphogenesis pertains to the creation of form. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0072028 ! nephron morphogenesis
relationship: part_of GO:0072087 ! renal vesicle development
relationship: part_of GO:0072088 ! nephron epithelium morphogenesis

[Term]
id: GO:0072078
name: nephron tubule morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a nephron tubule are generated and organized. Morphogenesis pertains to the creation of form. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0060562 ! epithelial tube morphogenesis
is_a: GO:0072088 ! nephron epithelium morphogenesis
relationship: part_of GO:0072028 ! nephron morphogenesis
relationship: part_of GO:0072080 ! nephron tubule development

[Term]
id: GO:0072079
name: nephron tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0072175 ! epithelial tube formation
relationship: part_of GO:0072078 ! nephron tubule morphogenesis

[Term]
id: GO:0072080
name: nephron tubule development
namespace: biological_process
def: "The progression of a nephron tubule over time, from its initial formation to the mature structure. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0072009 ! nephron epithelium development

[Term]
id: GO:0072081
name: specification of nephron tubule identity
namespace: biological_process
def: "The process by which the tubules arranged along the proximal/distal axis of the nephron acquire their identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0007379 ! segment specification
relationship: part_of GO:0072047 ! proximal/distal pattern formation involved in nephron development
relationship: part_of GO:0072079 ! nephron tubule formation

[Term]
id: GO:0072082
name: specification of proximal tubule identity
namespace: biological_process
def: "The process by which the proximal tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0072158 ! proximal tubule morphogenesis

[Term]
id: GO:0072084
name: specification of distal tubule identity
namespace: biological_process
def: "The process by which the distal tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0072156 ! distal tubule morphogenesis

[Term]
id: GO:0072085
name: specification of connecting tubule identity
namespace: biological_process
def: "The process by which the connecting tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0072027 ! connecting tubule development

[Term]
id: GO:0072086
name: specification of loop of Henle identity
namespace: biological_process
alt_id: GO:0072083
def: "The process by which the loop of Henle of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10]
synonym: "specification of intermediate tubule identity" EXACT []
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0072070 ! loop of Henle development

[Term]
id: GO:0072087
name: renal vesicle development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
relationship: part_of GO:0072009 ! nephron epithelium development

[Term]
id: GO:0072088
name: nephron epithelium morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the nephron epithelium are generated and organized. Morphogenesis pertains to the creation of form. The nephron epithelium is a tissue that covers the surface of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0002009 ! morphogenesis of an epithelium
relationship: part_of GO:0072009 ! nephron epithelium development

[Term]
id: GO:0072089
name: stem cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]
is_a: GO:0008283 ! cell proliferation

[Term]
id: GO:0072090
name: mesenchymal stem cell proliferation involved in nephron morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population, that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0072089 ! stem cell proliferation

[Term]
id: GO:0072091
name: regulation of stem cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10]
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0065007 ! biological regulation
relationship: regulates GO:0072089 ! stem cell proliferation

[Term]
id: GO:0072092
name: ureteric bud invasion
namespace: biological_process
def: "The process by which the ureteric bud grows along its axis and contributes to the formation of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0060677 ! ureteric bud elongation
relationship: part_of GO:0072093 ! metanephric renal vesicle formation

[Term]
id: GO:0072093
name: metanephric renal vesicle formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the metanephros." [GOC:mtg_kidney_jan10]
synonym: "metanephros formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0003338 ! metanephros morphogenesis

[Term]
id: GO:0072094
name: positive regulation of metanephric renal vesicle formation
namespace: biological_process
def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the metanephric renal vesicle." [GOC:mtg_kidney_jan10]
synonym: "positive regulation of metanephros formation" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072034 ! positive regulation of renal vesicle formation
relationship: positively_regulates GO:0072093 ! metanephric renal vesicle formation

[Term]
id: GO:0072095
name: regulation of branch elongation involved in ureteric bud branching
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10]
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis
relationship: regulates GO:0060681 ! branch elongation involved in ureteric bud branching

[Term]
id: GO:0072096
name: negative regulation of branch elongation involved in ureteric bud branching
namespace: biological_process
def: "Any process that reduces the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10]
is_a: GO:0048640 ! negative regulation of developmental growth
is_a: GO:0072095 ! regulation of branch elongation involved in ureteric bud branching
relationship: negatively_regulates GO:0060681 ! branch elongation involved in ureteric bud branching

[Term]
id: GO:0072097
name: negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor resulting in the reduction of the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10]
is_a: GO:0030509 ! BMP signaling pathway
is_a: GO:0072096 ! negative regulation of branch elongation involved in ureteric bud branching

[Term]
id: GO:0072098
name: anterior/posterior pattern specification involved in kidney development
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the kidney along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "anterior/posterior pattern formation involved in kidney development" RELATED [GOC:mtg_kidney_jan10]
synonym: "kidney anterior/posterior pattern formation" RELATED [GOC:mtg_kidney_jan10]
synonym: "kidney anterior/posterior pattern specification" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0061004 ! pattern specification involved in kidney development

[Term]
id: GO:0072099
name: ureteric bud anterior/posterior pattern specification
namespace: biological_process
def: "The developmental process that results in the creation of defined areas or spaces within the ureteric bud along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]
synonym: "ureteric bud anterior/posterior pattern formation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development
relationship: part_of GO:0001657 ! ureteric bud development

[Term]
id: GO:0072100
name: specification of ureteric bud anterior/posterior symmetry
namespace: biological_process
def: "The establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis." [GOC:mtg_kidney_jan10]
is_a: GO:0009799 ! specification of symmetry
is_a: GO:0072099 ! ureteric bud anterior/posterior pattern specification

[Term]
id: GO:0072101
name: specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
namespace: biological_process
def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis." [GOC:mtg_kidney_jan10]
is_a: GO:0030509 ! BMP signaling pathway
is_a: GO:0072100 ! specification of ureteric bud anterior/posterior symmetry

[Term]
id: GO:0072102
name: glomerulus morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the glomerulus are generated and organized. Morphogenesis pertains to the creation of form. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0032835 ! glomerulus development

[Term]
id: GO:0072103
name: glomerulus vasculature morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the glomerulus vasculature are generated and organized. Morphogenesis pertains to the creation of form. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0048514 ! blood vessel morphogenesis
relationship: part_of GO:0072012 ! glomerulus vasculature development
relationship: part_of GO:0072102 ! glomerulus morphogenesis

[Term]
id: GO:0072104
name: glomerular capillary formation
namespace: biological_process
def: "The process that gives rise to a glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0072103 ! glomerulus vasculature morphogenesis

[Term]
id: GO:0072105
name: ureteric peristalsis
namespace: biological_process
def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, impelling the contents onwards. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_kidney_jan10]
is_a: GO:0014849 ! ureter smooth muscle contraction
is_a: GO:0030432 ! peristalsis

[Term]
id: GO:0072106
name: regulation of ureteric bud formation
namespace: biological_process
def: "Any process that modulates the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0090183 ! regulation of kidney development
relationship: regulates GO:0060676 ! ureteric bud formation

[Term]
id: GO:0072107
name: positive regulation of ureteric bud formation
namespace: biological_process
def: "Any process that increases the rate or extent of the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0072106 ! regulation of ureteric bud formation
relationship: positively_regulates GO:0060676 ! ureteric bud formation

[Term]
id: GO:0072108
name: positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation
relationship: positively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis

[Term]
id: GO:0072109
name: glomerular mesangium development
namespace: biological_process
def: "The process whose specific outcome is the progression of the glomerular mesangium over time, from its formation to the mature structure. The glomerular mesangium is the thin membrane connective tissue composed of mesangial cells, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0072012 ! glomerulus vasculature development

[Term]
id: GO:0072110
name: glomerular mesangial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of glomerular mesangial cells, resulting in the expansion of the population." [GOC:mtg_kidney_jan10]
is_a: GO:0072111 ! cell proliferation involved in kidney development
relationship: part_of GO:0072109 ! glomerular mesangium development

[Term]
id: GO:0072111
name: cell proliferation involved in kidney development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072112
name: glomerular visceral epithelial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:mtg_kidney_jan10]
synonym: "podocyte differentiation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072010 ! glomerular epithelium development

[Term]
id: GO:0072113
name: head kidney development
namespace: biological_process
def: "The process whose specific outcome is the progression of the head kidney over time, from its formation to the mature structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. It is analogous to the mammalian bone marrow and the primary site of definitive hematopoiesis." [GOC:mtg_kidney_jan10, ZFA:0000669]
is_a: GO:0048793 ! pronephros development

[Term]
id: GO:0072114
name: pronephros morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the pronephros are generated and organized. Morphogenesis pertains to the creation of form. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10]
is_a: GO:0060993 ! kidney morphogenesis
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0072115
name: head kidney morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the head kidney are generated and organized. Morphogenesis pertains to the creation of form. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669]
is_a: GO:0072114 ! pronephros morphogenesis
relationship: part_of GO:0072113 ! head kidney development

[Term]
id: GO:0072116
name: pronephros formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the pronephros. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10]
is_a: GO:0072003 ! kidney rudiment formation
relationship: part_of GO:0072114 ! pronephros morphogenesis

[Term]
id: GO:0072117
name: head kidney formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the head kidney. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669]
is_a: GO:0072116 ! pronephros formation
relationship: part_of GO:0072115 ! head kidney morphogenesis

[Term]
id: GO:0072118
name: pronephros structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the pronephros. This process pertains to the physical shaping of a rudimentary structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10]
is_a: GO:0048532 ! anatomical structure arrangement
relationship: part_of GO:0072114 ! pronephros morphogenesis

[Term]
id: GO:0072119
name: head kidney structural organization
namespace: biological_process
def: "The process that contributes to the act of creating the structural organization of the head kidney. This process pertains to the physical shaping of a rudimentary structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669]
is_a: GO:0072118 ! pronephros structural organization
relationship: part_of GO:0072115 ! head kidney morphogenesis

[Term]
id: GO:0072120
name: pronephros maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pronephros to attain its fully functional state. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10]
is_a: GO:0021700 ! developmental maturation
relationship: part_of GO:0048793 ! pronephros development

[Term]
id: GO:0072121
name: head kidney maturation
namespace: biological_process
def: "A developmental process, independent of morphogenetic (shape) change, that is required for the head kidney to attain its fully functional state. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669]
is_a: GO:0072120 ! pronephros maturation
relationship: part_of GO:0072113 ! head kidney development

[Term]
id: GO:0072122
name: extraglomerular mesangial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of extraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." [GOC:mtg_kidney_jan10]
synonym: "Goormaghtigh proliferation" RELATED [GOC:mtg_kidney_jan10]
synonym: "lacis cell proliferation" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072110 ! glomerular mesangial cell proliferation

[Term]
id: GO:0072123
name: intraglomerular mesangial cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of intraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis." [GOC:mtg_kidney_jan10]
is_a: GO:0072110 ! glomerular mesangial cell proliferation

[Term]
id: GO:0072124
name: regulation of glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0090192 ! regulation of glomerulus development
relationship: regulates GO:0072110 ! glomerular mesangial cell proliferation

[Term]
id: GO:0072125
name: negative regulation of glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0008285 ! negative regulation of cell proliferation
is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation
relationship: negatively_regulates GO:0072110 ! glomerular mesangial cell proliferation

[Term]
id: GO:0072126
name: positive regulation of glomerular mesangial cell proliferation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]
is_a: GO:0008284 ! positive regulation of cell proliferation
is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation
relationship: positively_regulates GO:0072110 ! glomerular mesangial cell proliferation

[Term]
id: GO:0072127
name: renal capsule development
namespace: biological_process
def: "The process whose specific outcome is the progression of the renal capsule over time, from its formation to the mature structure. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0001822 ! kidney development

[Term]
id: GO:0072128
name: renal capsule morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the renal capsule are generated and organized. Morphogenesis pertains to the creation of form. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0072127 ! renal capsule development

[Term]
id: GO:0072129
name: renal capsule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a renal capsule from unspecified parts. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0072128 ! renal capsule morphogenesis

[Term]
id: GO:0072130
name: renal capsule specification
namespace: biological_process
def: "The regionalization process by which the identity of the renal capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10]
is_a: GO:0003002 ! regionalization
relationship: part_of GO:0072129 ! renal capsule formation

[Term]
id: GO:0072131
name: kidney mesenchyme morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a kidney mesenchymal tissue are generated and organized. Morphogenesis pertains to the creation of form. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0072132 ! mesenchyme morphogenesis
relationship: part_of GO:0072074 ! kidney mesenchyme development

[Term]
id: GO:0072132
name: mesenchyme morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a mesenchymal tissue are generated and organized. Morphogenesis pertains to the creation of form. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:mtg_kidney_jan10]
is_a: GO:0048729 ! tissue morphogenesis
relationship: part_of GO:0060485 ! mesenchyme development

[Term]
id: GO:0072133
name: metanephric mesenchyme morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a metanephric mesenchymal tissue are generated and organized. Morphogenesis pertains to the creation of form. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072131 ! kidney mesenchyme morphogenesis
relationship: part_of GO:0072075 ! metanephric mesenchyme development

[Term]
id: GO:0072134
name: nephrogenic mesenchyme morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a nephrogenic mesenchymal tissue are generated and organized. Morphogenesis pertains to the creation of form. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GOC:mtg_kidney_jan10]
is_a: GO:0072131 ! kidney mesenchyme morphogenesis
relationship: part_of GO:0072076 ! nephrogenic mesenchyme development

[Term]
id: GO:0072135
name: kidney mesenchymal cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0010463 ! mesenchymal cell proliferation
is_a: GO:0072111 ! cell proliferation involved in kidney development
relationship: part_of GO:0072074 ! kidney mesenchyme development

[Term]
id: GO:0072136
name: metanephric mesenchymal cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a metanephric mesenchymal cell population." [GOC:mtg_kidney_jan10]
is_a: GO:0072135 ! kidney mesenchymal cell proliferation
relationship: part_of GO:0072075 ! metanephric mesenchyme development

[Term]
id: GO:0072137
name: condensed mesenchymal cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a condensed mesenchymal cell population. A condensed mesenchymal cell population is a population of adherent mesenchymal cells." [GOC:mtg_kidney_jan10]
is_a: GO:0010463 ! mesenchymal cell proliferation

[Term]
id: GO:0072138
name: mesenchymal cell proliferation involved in ureteric bud development
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureteric bud, that contributes to ureteric bud development." [GOC:mtg_kidney_jan10]
synonym: "ureteric bud mesenchymal cell proliferation" BROAD [GOC:mtg_kidney_jan10]
is_a: GO:0010463 ! mesenchymal cell proliferation
relationship: part_of GO:0001657 ! ureteric bud development

[Term]
id: GO:0072139
name: glomerular parietal epithelial cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development

[Term]
id: GO:0072140
name: DCT cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a distal convoluted tubule cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
synonym: "distal convoluted tubule cell development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0072069 ! DCT cell differentiation

[Term]
id: GO:0072141
name: renal interstitial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a renal interstitial cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
synonym: "kidney interstitial cell development" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0072071 ! renal interstitial cell differentiation

[Term]
id: GO:0072142
name: juxtaglomerulus cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0072052 ! juxtaglomerulus cell differentiation

[Term]
id: GO:0072143
name: mesangial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesangial cell in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0072007 ! mesangial cell differentiation

[Term]
id: GO:0072144
name: glomerular mesangial cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072143 ! mesangial cell development
relationship: part_of GO:0072008 ! glomerular mesangial cell differentiation

[Term]
id: GO:0072145
name: S1 cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of an S1 cell in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0072062 ! S1 cell differentiation

[Term]
id: GO:0072146
name: DCT cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a distal convoluted tubule cell." [GOC:mtg_kidney_jan10]
synonym: "distal convoluted tubule cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0072069 ! DCT cell differentiation

[Term]
id: GO:0072147
name: glomerular parietal epithelial cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10]
synonym: "Bowman's capsule cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0072010 ! glomerular epithelium development
relationship: part_of GO:0072139 ! glomerular parietal epithelial cell differentiation

[Term]
id: GO:0072148
name: epithelial cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell." [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment

[Term]
id: GO:0072149
name: glomerular visceral epithelial cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells." [GOC:mtg_kidney_jan10]
synonym: "podocyte cell fate commitment" RELATED [GOC:mtg_kidney_jan10]
is_a: GO:0072148 ! epithelial cell fate commitment
relationship: part_of GO:0072112 ! glomerular visceral epithelial cell differentiation

[Term]
id: GO:0072150
name: juxtaglomerulus cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a juxtaglomerulus cell." [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0072052 ! juxtaglomerulus cell differentiation

[Term]
id: GO:0072151
name: mesangial cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a mesangial cell." [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0072007 ! mesangial cell differentiation

[Term]
id: GO:0072152
name: glomerular mesangial cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a glomerular mesangial cell." [GOC:mtg_kidney_jan10]
is_a: GO:0072151 ! mesangial cell fate commitment
relationship: part_of GO:0072008 ! glomerular mesangial cell differentiation

[Term]
id: GO:0072153
name: renal interstitial cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a renal interstitial cell." [GOC:mtg_kidney_jan10]
synonym: "kidney interstitial cell fate commitment" EXACT [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0072071 ! renal interstitial cell differentiation

[Term]
id: GO:0072154
name: S1 cell fate commitment
namespace: biological_process
def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into an S1 cell in the kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0072062 ! S1 cell differentiation

[Term]
id: GO:0072155
name: epithelial cell migration involved in nephron tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to nephron tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0010631 ! epithelial cell migration
relationship: part_of GO:0072078 ! nephron tubule morphogenesis

[Term]
id: GO:0072156
name: distal tubule morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a distal tubule are generated and organized. Morphogenesis pertains to the creation of form. The distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072078 ! nephron tubule morphogenesis
relationship: part_of GO:0072017 ! distal tubule development

[Term]
id: GO:0072157
name: epithelial cell migration involved in distal tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to distal tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis
relationship: part_of GO:0072156 ! distal tubule morphogenesis

[Term]
id: GO:0072158
name: proximal tubule morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a proximal tubule are generated and organized. Morphogenesis pertains to the creation of form. The proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10]
is_a: GO:0072078 ! nephron tubule morphogenesis
relationship: part_of GO:0072014 ! proximal tubule development

[Term]
id: GO:0072159
name: epithelial cell migration involved in proximal tubule morphogenesis
namespace: biological_process
def: "The orderly movement of epithelial cells within a renal tubule that contributes to proximal tubule morphogenesis." [GOC:mtg_kidney_jan10]
is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis
relationship: part_of GO:0072014 ! proximal tubule development

[Term]
id: GO:0072160
name: nephron tubule epithelial cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0030855 ! epithelial cell differentiation
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072080 ! nephron tubule development

[Term]
id: GO:0072161
name: mesenchymal cell differentiation involved in kidney development
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0048762 ! mesenchymal cell differentiation
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072074 ! kidney mesenchyme development

[Term]
id: GO:0072162
name: metanephric mesenchymal cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]
is_a: GO:0072161 ! mesenchymal cell differentiation involved in kidney development
relationship: part_of GO:0072075 ! metanephric mesenchyme development

[Term]
id: GO:0072163
name: mesonephric epithelium development
namespace: biological_process
def: "The process whose specific outcome is the progression of an epithelium in the mesonephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10]
is_a: GO:0072073 ! kidney epithelium development
relationship: part_of GO:0001823 ! mesonephros development

[Term]
id: GO:0072164
name: mesonephric tubule development
namespace: biological_process
def: "The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072080 ! nephron tubule development
is_a: GO:0072163 ! mesonephric epithelium development

[Term]
id: GO:0072165
name: anterior mesonephric tubule development
namespace: biological_process
def: "The progression of the anterior mesonephric tubule over time, from its initial formation to the mature structure. The anterior mesonephric tubule is an epithelial tube that is part of the mesonephros." []
is_a: GO:0072164 ! mesonephric tubule development

[Term]
id: GO:0072166
name: posterior mesonephric tubule development
namespace: biological_process
def: "The progression of the posterior mesonephric tubule over time, from its initial formation to the mature structure. The posterior mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072164 ! mesonephric tubule development

[Term]
id: GO:0072167
name: specification of mesonephric tubule identity
namespace: biological_process
def: "The process by which the tubules of the mesonephros acquire their identity." [GOC:mtg_kidney_jan10]
is_a: GO:0072081 ! specification of nephron tubule identity
relationship: part_of GO:0072172 ! mesonephric tubule formation

[Term]
id: GO:0072168
name: specification of anterior mesonephric tubule identity
namespace: biological_process
def: "The process by which the tubules of the anterior mesonephros acquire their identity." [GOC:mtg_kidney_jan10]
is_a: GO:0072167 ! specification of mesonephric tubule identity
relationship: part_of GO:0072165 ! anterior mesonephric tubule development

[Term]
id: GO:0072169
name: specification of posterior mesonephric tubule identity
namespace: biological_process
def: "The process by which the tubules of the posterior mesonephros acquire their identity." [GOC:mtg_kidney_jan10]
is_a: GO:0072167 ! specification of mesonephric tubule identity
relationship: part_of GO:0072166 ! posterior mesonephric tubule development

[Term]
id: GO:0072170
name: metanephric tubule development
namespace: biological_process
def: "The progression of a metanephric tubule over time, from its initial formation to the mature structure. A metanephric tubule is an epithelial tube that is part of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development
relationship: part_of GO:0001656 ! metanephros development

[Term]
id: GO:0072171
name: mesonephric tubule morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a mesonephric tubule are generated and organized. Morphogenesis pertains to the creation of form. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072078 ! nephron tubule morphogenesis
relationship: part_of GO:0072164 ! mesonephric tubule development

[Term]
id: GO:0072172
name: mesonephric tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a mesonephric tubule from unspecified parts. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072079 ! nephron tubule formation
relationship: part_of GO:0072171 ! mesonephric tubule morphogenesis

[Term]
id: GO:0072173
name: metanephric tubule morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of a metanephric tubule are generated and organized from an epithelium. Morphogenesis pertains to the creation of form. A metanephric tubule is an epithelial tube that is part of the metanephros." [GOC:mtg_kidney_jan10]
is_a: GO:0060562 ! epithelial tube morphogenesis
relationship: part_of GO:0072170 ! metanephric tubule development

[Term]
id: GO:0072174
name: metanephric tubule formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a metanephric tubule." [GOC:mtg_kidney_jan10]
is_a: GO:0072175 ! epithelial tube formation
relationship: part_of GO:0072173 ! metanephric tubule morphogenesis

[Term]
id: GO:0072175
name: epithelial tube formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of an epithelial tube." [GOC:mtg_kidney_jan10]
is_a: GO:0035148 ! tube formation
relationship: part_of GO:0060562 ! epithelial tube morphogenesis

[Term]
id: GO:0072176
name: nephric duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0035295 ! tube development

[Term]
id: GO:0072177
name: mesonephric duct development
namespace: biological_process
def: "The process whose specific outcome is the progression of a mesonephric duct over time, from its initial formation to a mature structure. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072176 ! nephric duct development

[Term]
id: GO:0072178
name: nephric duct  morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the nephric duct are generated and organized. Morphogenesis pertains to the creation of form. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0072176 ! nephric duct development

[Term]
id: GO:0072179
name: nephric duct  formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a nephric duct. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0072178 ! nephric duct  morphogenesis

[Term]
id: GO:0072180
name: mesonephric duct  morphogenesis
namespace: biological_process
def: "The process by which the anatomical structures of the mesonephric duct are generated and organized. Morphogenesis pertains to the creation of form. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072178 ! nephric duct  morphogenesis
relationship: part_of GO:0072177 ! mesonephric duct development

[Term]
id: GO:0072181
name: mesonephric duct  formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a mesonephric duct. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10]
is_a: GO:0072179 ! nephric duct  formation
is_a: GO:0072180 ! mesonephric duct  morphogenesis

[Term]
id: GO:0072182
name: regulation of nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:0030856 ! regulation of epithelial cell differentiation
relationship: regulates GO:0072160 ! nephron tubule epithelial cell differentiation

[Term]
id: GO:0072183
name: negative regulation of nephron tubule epithelial cell differentiation
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]
is_a: GO:0030857 ! negative regulation of epithelial cell differentiation
is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation
relationship: negatively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation

[Term]
id: GO:0072184
name: renal vesicle progenitor cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features that characterize the renal vesicle progenitor cells of the kidney as it progresses from its formation to the mature state. A renal vesicle progenitor cell is a cell that will give rise to terminally differentiated cells of the renal vesicle without self-renewing." [GOC:mtg_kidney_jan10]
is_a: GO:0061005 ! cell differentiation involved in kidney development
relationship: part_of GO:0072087 ! renal vesicle development

[Term]
id: GO:0075000
name: response to host osmotic environment
namespace: biological_process
def: "A change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "response of symbiont to host osmotic environment" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075001
name: adhesion of symbiont infection structure to host
namespace: biological_process
def: "The attachment of an infection structure of the symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process.
synonym: "adhesion of symbiont infection structure to host during symbiotic interaction" EXACT []
synonym: "attachment of symbiont infection structure to host" EXACT []
is_a: GO:0044406 ! adhesion to host

[Term]
id: GO:0075002
name: adhesion of symbiont germination tube to host
namespace: biological_process
def: "The attachment of a germination tube of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont germination tube to host during symbiotic interaction" EXACT []
is_a: GO:0075001 ! adhesion of symbiont infection structure to host

[Term]
id: GO:0075003
name: adhesion of symbiont appressorium to host
namespace: biological_process
def: "The attachment of an appressorium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont appressorium to host during symbiotic interaction" EXACT []
is_a: GO:0075001 ! adhesion of symbiont infection structure to host

[Term]
id: GO:0075004
name: adhesion of symbiont spore to host
namespace: biological_process
def: "The attachment of a spore of the symbiont to its host via adhesion molecules, general stickiness etc. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont spore to host during symbiotic interaction" EXACT []
is_a: GO:0044406 ! adhesion to host

[Term]
id: GO:0075005
name: spore germination on or near host
namespace: biological_process
def: "The physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0009847 ! spore germination
is_a: GO:0044132 ! development of symbiont on or near host
is_a: GO:0051701 ! interaction with host

[Term]
id: GO:0075006
name: modulation of spore germination on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore germination on or near host, which is the physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044138 ! modulation of development of symbiont on or near host
relationship: regulates GO:0075005 ! spore germination on or near host

[Term]
id: GO:0075007
name: positive regulation of spore germination on or near host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of spore germination on or near host, which is the physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface
is_a: GO:0075006 ! modulation of spore germination on or near host
relationship: positively_regulates GO:0075005 ! spore germination on or near host

[Term]
id: GO:0075008
name: negative regulation of spore germination on or near host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of spore germination on or near host, which is the physiological, developmental and morphological changes that occur in a symbiont spore following release from dormancy up to the earliest signs of growth occurring on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface
is_a: GO:0075006 ! modulation of spore germination on or near host
relationship: negatively_regulates GO:0075005 ! spore germination on or near host

[Term]
id: GO:0075009
name: germ tube formation on or near host
namespace: biological_process
def: "Development of slender tubular outgrowth first produced by most symbiont spores immediately following germination on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044132 ! development of symbiont on or near host
relationship: part_of GO:0075005 ! spore germination on or near host

[Term]
id: GO:0075010
name: modulation of germ tube formation on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075006 ! modulation of spore germination on or near host
relationship: regulates GO:0075009 ! germ tube formation on or near host

[Term]
id: GO:0075011
name: positive regulation of germ tube formation on or near host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075007 ! positive regulation of spore germination on or near host
is_a: GO:0075010 ! modulation of germ tube formation on or near host
relationship: positively_regulates GO:0075009 ! germ tube formation on or near host

[Term]
id: GO:0075012
name: negative regulation of germ tube formation on or near host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075008 ! negative regulation of spore germination on or near host
is_a: GO:0075010 ! modulation of germ tube formation on or near host
relationship: negatively_regulates GO:0075009 ! germ tube formation on or near host

[Term]
id: GO:0075013
name: growth or development of symbiont on or near host phyllosphere
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of symbiont on or near host phyllosphere ; GO:0044135' and 'development of symbiont on or near host phyllosphere ; GO:0044134'.
is_obsolete: true
replaced_by: GO:0044134
replaced_by: GO:0044135

[Term]
id: GO:0075014
name: growth or development of symbiont on or near host rhizosphere
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'growth of symbiont on or near host rhizosphere ; GO:0044137' and 'development of symbiont on or near host rhizosphere ; GO:0044136'.
is_obsolete: true
replaced_by: GO:0044136
replaced_by: GO:0044137

[Term]
id: GO:0075015
name: formation of infection structure on or near host
namespace: biological_process
def: "The process by which a symbiont structure that serves to infect the host is formed on or near its host organism. It includes physiological, developmental, and morphological changes of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process.
synonym: "formation by symbiont of infection structure on or near host" EXACT []
is_a: GO:0044115 ! development of symbiont during interaction with host
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis

[Term]
id: GO:0075016
name: appressorium formation on or near host
namespace: biological_process
def: "The process by which a swollen, flattened portion of a symbiont filament is formed on or near its host organism, to adhere to and for the purpose of penetrating the host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "appressorium formation for entry into host, on or near host" EXACT []
synonym: "formation of an appressorium by symbiont on or near host" EXACT []
is_a: GO:0044134 ! development of symbiont on or near host phyllosphere
is_a: GO:0075015 ! formation of infection structure on or near host

[Term]
id: GO:0075017
name: regulation of appressorium formation on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044138 ! modulation of development of symbiont on or near host
relationship: regulates GO:0075016 ! appressorium formation on or near host

[Term]
id: GO:0075018
name: positive regulation of appressorium formation on or near host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface
is_a: GO:0075017 ! regulation of appressorium formation on or near host
relationship: positively_regulates GO:0075016 ! appressorium formation on or near host

[Term]
id: GO:0075019
name: negative regulation of appressorium formation on or near host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface
is_a: GO:0075017 ! regulation of appressorium formation on or near host
relationship: negatively_regulates GO:0075016 ! appressorium formation on or near host

[Term]
id: GO:0075020
name: calcium or calmodulin-mediated activation of appressorium formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont calcium or calmodulin-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "Ca++ or calmodulin-mediated activation of appressorium formation" EXACT []
synonym: "Ca2+ or calmodulin-mediated activation of appressorium formation" EXACT []
is_a: GO:0075018 ! positive regulation of appressorium formation on or near host

[Term]
id: GO:0075021
name: cAMP-mediated activation of appressorium formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont cAMP mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "cyclic AMP mediated activation of appressorium formation" EXACT []
is_a: GO:0075018 ! positive regulation of appressorium formation on or near host

[Term]
id: GO:0075022
name: ethylene-mediated activation of appressorium formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont ethylene-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075018 ! positive regulation of appressorium formation on or near host

[Term]
id: GO:0075023
name: MAPK-mediated regulation of appressorium formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "mitogen-activated protein kinase-mediated activation of appressorium formation" EXACT []
is_a: GO:0075018 ! positive regulation of appressorium formation on or near host

[Term]
id: GO:0075024
name: phospholipase C-mediated activation of appressorium formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont phospholipase C-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075018 ! positive regulation of appressorium formation on or near host

[Term]
id: GO:0075025
name: initiation of appressorium on or near host
namespace: biological_process
def: "The process whereby a relatively unspecialized cell starts to acquire specialized features of the symbiont appressorium to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "appressorium initiation on or near host" EXACT []
synonym: "initiation of appressorium by symbiont on or near host" EXACT []
synonym: "initiation of symbiont appressorium on or near host" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0075016 ! appressorium formation on or near host

[Term]
id: GO:0075026
name: regulation of appressorium initiation on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont appressorium initiation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "regulation of initiation of appressorium on or near host" EXACT []
is_a: GO:0075017 ! regulation of appressorium formation on or near host
relationship: regulates GO:0075025 ! initiation of appressorium on or near host

[Term]
id: GO:0075027
name: positive regulation of appressorium initiation on or near host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium initiation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "positive regulation of initiation of appressorium on or near host" EXACT []
is_a: GO:0075018 ! positive regulation of appressorium formation on or near host
is_a: GO:0075026 ! regulation of appressorium initiation on or near host
relationship: positively_regulates GO:0075025 ! initiation of appressorium on or near host

[Term]
id: GO:0075028
name: negative regulation of appressorium initiation on or near host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent symbiont appressorium initiation near or on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "negative regulation of initiation of appressorium on or near host" EXACT []
is_a: GO:0075019 ! negative regulation of appressorium formation on or near host
is_a: GO:0075026 ! regulation of appressorium initiation on or near host
relationship: negatively_regulates GO:0075025 ! initiation of appressorium on or near host

[Term]
id: GO:0075029
name: formation of symbiont germ tube hook structure on or near host
namespace: biological_process
def: "The development of a swollen tip at the growing end of a symbiont spore which usually flattens against the host cell surface prior to appressorium formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "formation of germ tube tip of symbiont on or near the exterior of host" EXACT []
synonym: "symbiont germ tube hook structure formation on or near host" EXACT []
is_a: GO:0075015 ! formation of infection structure on or near host
relationship: part_of GO:0075025 ! initiation of appressorium on or near host

[Term]
id: GO:0075030
name: modulation of symbiont germ tube hook structure formation on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont germ tube hook structure formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "modulation of germ tube tip of symbiont on or near the exterior of host" EXACT []
synonym: "regulation of formation of symbiont germ tube hook structure on or near host" EXACT []
is_a: GO:0075026 ! regulation of appressorium initiation on or near host
relationship: regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host

[Term]
id: GO:0075031
name: positive regulation of symbiont germ tube hook structure formation on or near host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont germ tube hook structure formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "positive regulation of formation of symbiont germ tube hook structure on or near host" EXACT []
synonym: "positive regulation of germ tube tip of symbiont on or near the exterior of host" EXACT []
is_a: GO:0075027 ! positive regulation of appressorium initiation on or near host
is_a: GO:0075030 ! modulation of symbiont germ tube hook structure formation on or near host
relationship: positively_regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host

[Term]
id: GO:0075032
name: negative regulation of symbiont germ tube hook structure formation on or near host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont germ tube hook structure formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "negative regulation of formation of symbiont germ tube hook structure on or near host" EXACT []
synonym: "negative regulation of germ tube tip of symbiont on or near the exterior of host" EXACT []
is_a: GO:0075028 ! negative regulation of appressorium initiation on or near host
is_a: GO:0075030 ! modulation of symbiont germ tube hook structure formation on or near host
relationship: negatively_regulates GO:0075029 ! formation of symbiont germ tube hook structure on or near host

[Term]
id: GO:0075033
name: septum formation during appressorium formation on or near host
namespace: biological_process
def: "The process by which a symbiont partition is formed to separate the appressorium from the germination tube, occurring on or near the exterior of its host organism during appressorium formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044132 ! development of symbiont on or near host
relationship: part_of GO:0075016 ! appressorium formation on or near host

[Term]
id: GO:0075034
name: nuclear division during appressorium formation on or near host
namespace: biological_process
def: "The process by which nuclear division occurs within a symbiont spore during appressorium formation on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0000280 ! nuclear division
relationship: part_of GO:0075016 ! appressorium formation on or near host

[Term]
id: GO:0075035
name: maturation of appressorium on or near host
namespace: biological_process
def: "The process whereby specialized features of the symbiont appressorium are acquired post initiation, to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "appressorium maturation on or near host" EXACT []
synonym: "maturation of symbiont appressorium on or near host" EXACT []
is_a: GO:0044115 ! development of symbiont during interaction with host
relationship: part_of GO:0075016 ! appressorium formation on or near host

[Term]
id: GO:0075036
name: regulation of appressorium maturation on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont appressorium maturation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "regulation of maturation of appressorium on or near host" EXACT []
is_a: GO:0075017 ! regulation of appressorium formation on or near host
relationship: regulates GO:0075035 ! maturation of appressorium on or near host

[Term]
id: GO:0075037
name: positive regulation of appressorium maturation on or near host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium maturation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "positive regulation maturation of appressorium on or near host" EXACT []
is_a: GO:0075018 ! positive regulation of appressorium formation on or near host
is_a: GO:0075036 ! regulation of appressorium maturation on or near host
relationship: positively_regulates GO:0075035 ! maturation of appressorium on or near host

[Term]
id: GO:0075038
name: negative regulation of appressorium maturation on or near host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent symbiont appressorium maturation in, near or on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "negative regulation of maturation of appressorium on or near host" EXACT []
is_a: GO:0075019 ! negative regulation of appressorium formation on or near host
is_a: GO:0075036 ! regulation of appressorium maturation on or near host
relationship: negatively_regulates GO:0075035 ! maturation of appressorium on or near host

[Term]
id: GO:0075039
name: establishment of turgor in appressorium
namespace: biological_process
def: "The process whereby hydrostatic pressure is increased within the symbiont appressorium to breach the cuticle of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "establishment of turgor in symbiont appressorium on or near host" EXACT []
synonym: "formation of turgor in appressorium" EXACT []
synonym: "generation of turgor in appressorium" EXACT []
is_a: GO:0044115 ! development of symbiont during interaction with host
relationship: part_of GO:0075035 ! maturation of appressorium on or near host

[Term]
id: GO:0075040
name: regulation of establishment of turgor in appressorium
namespace: biological_process
def: "Any process modulates the frequency, rate or extent of turgor formation in the symbiont appressorium on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "regulation of turgor formation in appressorium" RELATED []
is_a: GO:0075036 ! regulation of appressorium maturation on or near host
relationship: regulates GO:0075039 ! establishment of turgor in appressorium

[Term]
id: GO:0075041
name: positive regulation of establishment of turgor in appressorium
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of turgor formation in the symbiont appressorium on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075018 ! positive regulation of appressorium formation on or near host
is_a: GO:0075040 ! regulation of establishment of turgor in appressorium
relationship: positively_regulates GO:0075039 ! establishment of turgor in appressorium

[Term]
id: GO:0075042
name: negative regulation of establishment of turgor in appressorium
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of turgor formation in the symbiont appressorium on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075038 ! negative regulation of appressorium maturation on or near host
is_a: GO:0075040 ! regulation of establishment of turgor in appressorium
relationship: negatively_regulates GO:0075039 ! establishment of turgor in appressorium

[Term]
id: GO:0075043
name: maintenance of turgor in appressorium by melanization
namespace: biological_process
def: "The process whereby melanin is produced in the appressorium of the symbiont on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "melanization of appressorium to maintain turgor pressure" EXACT []
is_a: GO:0042438 ! melanin biosynthetic process
is_a: GO:0075040 ! regulation of establishment of turgor in appressorium

[Term]
id: GO:0075044
name: autophagy of host cells during interaction with symbiont
namespace: biological_process
def: "The process by which the host cells digest parts of their own cytoplasm during interaction with its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should be used to annotate gene products of host.
is_a: GO:0075071 ! autophagy during symbiotic interaction

[Term]
id: GO:0075045
name: regulation of formation by symbiont of haustorium for nutrient acquisition from host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044127 ! regulation of development of symbiont in host
is_a: GO:0060259 ! regulation of feeding behavior
relationship: regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host

[Term]
id: GO:0075046
name: positive regulation of formation by symbiont of haustorium for nutrient acquisition from host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044129 ! positive regulation of development of symbiont in host
is_a: GO:0075045 ! regulation of formation by symbiont of haustorium for nutrient acquisition from host
relationship: positively_regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host

[Term]
id: GO:0075047
name: negative regulation of formation by symbiont of haustorium for nutrient acquisition from host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044131 ! negative regulation of development of symbiont in host
is_a: GO:0075045 ! regulation of formation by symbiont of haustorium for nutrient acquisition from host
relationship: negatively_regulates GO:0052094 ! formation by symbiont of haustorium for nutrient acquisition from host

[Term]
id: GO:0075048
name: cell wall strengthening in symbiont during entry into host
namespace: biological_process
def: "A process whereby the cell wall of the symbiont is strengthened or thickened during penetration into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "cell wall thickening in symbiont during entry into host" EXACT []
synonym: "symbiont cell wall strengthening during entry into host" EXACT []
is_a: GO:0052386 ! cell wall thickening
relationship: part_of GO:0044409 ! entry into host

[Term]
id: GO:0075049
name: modulation of symbiont cell wall strengthening during entry into host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0052372 ! modulation by symbiont of entry into host
relationship: regulates GO:0075048 ! cell wall strengthening in symbiont during entry into host

[Term]
id: GO:0075050
name: positive regulation of symbiont cell wall strengthening during entry into host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0075049 ! modulation of symbiont cell wall strengthening during entry into host
is_a: GO:0075294 ! positive regulation by symbiont of entry into host
relationship: positively_regulates GO:0075048 ! cell wall strengthening in symbiont during entry into host

[Term]
id: GO:0075051
name: negative regulation of symbiont cell wall strengthening during entry into host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0052374 ! negative regulation by symbiont of entry into host
is_a: GO:0075049 ! modulation of symbiont cell wall strengthening during entry into host
relationship: negatively_regulates GO:0075048 ! cell wall strengthening in symbiont during entry into host

[Term]
id: GO:0075052
name: entry into host via a specialized structure
namespace: biological_process
def: "Penetration via a specialized structure of symbiont into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "entry into host via a specialized structure during symbiotic interaction" EXACT []
is_a: GO:0044409 ! entry into host

[Term]
id: GO:0075053
name: formation of symbiont penetration peg for entry into host
namespace: biological_process
def: "The assembly by the symbiont of a peg-like structure for the purpose of penetration into its host organism, which penetrates through the host cuticle and epidermal cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "symbiont penetration peg formation for entry into host" EXACT []
is_a: GO:0075015 ! formation of infection structure on or near host
relationship: part_of GO:0075052 ! entry into host via a specialized structure

[Term]
id: GO:0075054
name: modulation of symbiont penetration peg formation for entry into host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044145 ! modulation of development of symbiont during interaction with host
is_a: GO:0052372 ! modulation by symbiont of entry into host
relationship: regulates GO:0075053 ! formation of symbiont penetration peg for entry into host

[Term]
id: GO:0075055
name: positive regulation of symbiont penetration peg formation for entry into host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0044149 ! positive regulation of development of symbiont during interaction with host
is_a: GO:0075054 ! modulation of symbiont penetration peg formation for entry into host
is_a: GO:0075294 ! positive regulation by symbiont of entry into host
relationship: positively_regulates GO:0075053 ! formation of symbiont penetration peg for entry into host

[Term]
id: GO:0075056
name: negative regulation of symbiont penetration peg formation for entry into host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0044147 ! negative regulation of development of symbiont during interaction with host
is_a: GO:0052374 ! negative regulation by symbiont of entry into host
is_a: GO:0075054 ! modulation of symbiont penetration peg formation for entry into host
relationship: negatively_regulates GO:0075053 ! formation of symbiont penetration peg for entry into host

[Term]
id: GO:0075057
name: initiation of symbiont penetration peg
namespace: biological_process
def: "The process whereby a relatively unspecialized cell of the symbiont starts to acquire the characteristics of a mature penetration peg to penetrate into its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "symbiont penetration peg initiation" EXACT []
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0075053 ! formation of symbiont penetration peg for entry into host

[Term]
id: GO:0075058
name: modulation of symbiont penetration peg initiation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of penetration peg initiation, the process whereby a relatively unspecialized cell start to acquire the characteristics of a mature penetration peg when the symbiont penetrates its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075054 ! modulation of symbiont penetration peg formation for entry into host
relationship: regulates GO:0075057 ! initiation of symbiont penetration peg

[Term]
id: GO:0075059
name: positive regulation of symbiont penetration peg initiation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration peg initiation, the process whereby a relatively unspecialized cell starts to acquire the characteristics of a mature penetration peg during the symbiont penetrating into its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075055 ! positive regulation of symbiont penetration peg formation for entry into host
is_a: GO:0075058 ! modulation of symbiont penetration peg initiation
relationship: positively_regulates GO:0075057 ! initiation of symbiont penetration peg

[Term]
id: GO:0075060
name: negative regulation of symbiont penetration peg initiation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont penetration peg initiation, the process whereby a relatively unspecialized cell starts to acquire the characteristics of a mature penetration peg during the symbiont penetrating into its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075056 ! negative regulation of symbiont penetration peg formation for entry into host
is_a: GO:0075058 ! modulation of symbiont penetration peg initiation
relationship: negatively_regulates GO:0075057 ! initiation of symbiont penetration peg

[Term]
id: GO:0075061
name: formation of symbiont invasive hypha in host
namespace: biological_process
def: "The assembly by the symbiont of a threadlike, tubular structure, which may contain multiple nuclei and may or may not be divided internally by septa or cross-walls, for the purpose of invasive growth within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "formation of symbiont invasive hypha within host" EXACT []
synonym: "formation of symbiont invasive hypha within host during symbiotic interaction" EXACT []
synonym: "symbiont invasive hypha formation within host" EXACT []
is_a: GO:0044114 ! development of symbiont in host

[Term]
id: GO:0075062
name: regulation of symbiont invasive hypha formation in host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "regulation of symbiont invasive hypha formation within host" EXACT []
is_a: GO:0044127 ! regulation of development of symbiont in host
relationship: regulates GO:0075061 ! formation of symbiont invasive hypha in host

[Term]
id: GO:0075063
name: positive regulation of symbiont invasive hypha formation in host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "positive regulation of symbiont invasive hypha formation within host" EXACT []
is_a: GO:0044129 ! positive regulation of development of symbiont in host
is_a: GO:0075062 ! regulation of symbiont invasive hypha formation in host
relationship: positively_regulates GO:0075061 ! formation of symbiont invasive hypha in host

[Term]
id: GO:0075064
name: negative regulation of symbiont invasive hypha formation in host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "negative regulation of symbiont invasive hypha formation within host" EXACT []
is_a: GO:0044131 ! negative regulation of development of symbiont in host
is_a: GO:0075062 ! regulation of symbiont invasive hypha formation in host
relationship: negatively_regulates GO:0075061 ! formation of symbiont invasive hypha in host

[Term]
id: GO:0075065
name: growth or development of symbiont in host cell
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host cell ; GO:0044118' and 'growth of symbiont in host cell ; GO:0044119'.
is_obsolete: true
replaced_by: GO:0044118
replaced_by: GO:0044119

[Term]
id: GO:0075066
name: growth or development of symbiont in host organelle
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host organelle ; GO:0044120' and 'growth of symbiont in host organelle ; GO:0044121'.
is_obsolete: true
replaced_by: GO:0044120
replaced_by: GO:0044121

[Term]
id: GO:0075067
name: growth or development of symbiont in host intercellular space
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development during symbiotic interaction ; GO:0044111' and 'growth of symbiont in host intercellular space ; GO:0044125'.
is_obsolete: true
replaced_by: GO:0044124
replaced_by: GO:0044125

[Term]
id: GO:0075068
name: growth or development of symbiont in host vascular tissue
namespace: biological_process
def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host vascular tissue ; GO:0044122' and 'growth of symbiont in host vascular tissue ; GO:0044123'.
is_obsolete: true
replaced_by: GO:0044122
replaced_by: GO:0044123

[Term]
id: GO:0075069
name: adhesion of symbiont infection cushion to host
namespace: biological_process
def: "The attachment of an infection cushion of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont infection cushion to host during symbiotic interaction" EXACT []
is_a: GO:0075001 ! adhesion of symbiont infection structure to host

[Term]
id: GO:0075070
name: adhesion of symbiont hyphopodium to host
namespace: biological_process
def: "The attachment of a hyphopodium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "adhesion of symbiont hyphopodium to host during symbiotic interaction" EXACT []
is_a: GO:0075001 ! adhesion of symbiont infection structure to host

[Term]
id: GO:0075071
name: autophagy during symbiotic interaction
namespace: biological_process
def: "The process by which cells digest parts of their own cytoplasm during a symbiotic interaction; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should be used to annotate gene products of the organism involved in this process.
is_a: GO:0006914 ! autophagy
relationship: part_of GO:0044403 ! symbiosis, encompassing mutualism through parasitism

[Term]
id: GO:0075072
name: autophagy of symbiont cells during interaction with host
namespace: biological_process
def: "The process by which symbiont cells digest parts of their own cytoplasm during interaction with its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should be used to annotate gene products of symbiont.
is_a: GO:0075071 ! autophagy during symbiotic interaction
relationship: part_of GO:0051701 ! interaction with host

[Term]
id: GO:0075073
name: autophagy of symbiont cells on or near host surface
namespace: biological_process
def: "The process by which symbiont cells digest parts of their own cytoplasm, occurring when the symbiont is on or near its host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should be used to annotate gene products of symbiont.
is_a: GO:0075072 ! autophagy of symbiont cells during interaction with host

[Term]
id: GO:0075074
name: spore autophagy during appressorium formation on or near host
namespace: biological_process
def: "The process by which a symbiont spore digests parts of its own cytoplasm, occurring when the appressorium forms on or near the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "autophagy of spores during appressorium formation on or near host" EXACT []
is_a: GO:0075073 ! autophagy of symbiont cells on or near host surface
relationship: part_of GO:0075016 ! appressorium formation on or near host

[Term]
id: GO:0075075
name: modulation by host of symbiont adenylate cyclase activity
namespace: biological_process
def: "Any process by which the host organism modulates the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host adenylate cyclase activity ; GO:0075106".
is_a: GO:0045761 ! regulation of adenylate cyclase activity
is_a: GO:0052422 ! modulation by host of symbiont catalytic activity

[Term]
id: GO:0075076
name: positive regulation by host of symbiont adenylate cyclase activity
namespace: biological_process
def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host adenylate cyclase activity ; GO:0075107".
is_a: GO:0043947 ! positive regulation by host of symbiont catalytic activity
is_a: GO:0045762 ! positive regulation of adenylate cyclase activity
is_a: GO:0075075 ! modulation by host of symbiont adenylate cyclase activity

[Term]
id: GO:0075077
name: negative regulation by host of symbiont adenylate cyclase activity
namespace: biological_process
def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host adenylate cyclase activity ; GO:0075108".
is_a: GO:0007194 ! negative regulation of adenylate cyclase activity
is_a: GO:0052403 ! negative regulation by host of symbiont catalytic activity
is_a: GO:0075075 ! modulation by host of symbiont adenylate cyclase activity

[Term]
id: GO:0075078
name: modulation by host of symbiont receptor-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism modulates the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host receptor-mediated signal transduction ; GO:0075109".
is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway

[Term]
id: GO:0075079
name: positive regulation by host of symbiont receptor-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host receptor-mediated signal transduction ; GO:0075110".
is_a: GO:0075078 ! modulation by host of symbiont receptor-mediated signal transduction

[Term]
id: GO:0075080
name: negative regulation by host of symbiont receptor-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host receptor-mediated signal transduction ; GO:0075111".
is_a: GO:0075078 ! modulation by host of symbiont receptor-mediated signal transduction

[Term]
id: GO:0075081
name: modulation by host of symbiont transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host transmembrane receptor-mediated signal transduction ; GO:0075112".
is_a: GO:0075078 ! modulation by host of symbiont receptor-mediated signal transduction

[Term]
id: GO:0075082
name: positive regulation by host of symbiont transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host transmembrane receptor-mediated signal transduction ; GO:0075113".
is_a: GO:0075079 ! positive regulation by host of symbiont receptor-mediated signal transduction
is_a: GO:0075081 ! modulation by host of symbiont transmembrane receptor-mediated signal transduction

[Term]
id: GO:0075083
name: negative regulation by host of symbiont transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host transmembrane receptor-mediated signal transduction ; GO:0075114".
is_a: GO:0075080 ! negative regulation by host of symbiont receptor-mediated signal transduction
is_a: GO:0075081 ! modulation by host of symbiont transmembrane receptor-mediated signal transduction

[Term]
id: GO:0075084
name: modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "Any process by which the host organism modulates the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction ; GO:0075115".
synonym: "modulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT []
is_a: GO:0075081 ! modulation by host of symbiont transmembrane receptor-mediated signal transduction
is_a: GO:0075205 ! modulation by host of symbiont cAMP-mediated signal transduction

[Term]
id: GO:0075085
name: positive regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction ; GO:0075116".
synonym: "activation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "positive regulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT []
synonym: "promotion by host of symbiont transmembrane receptor protein activity involved in cAMP-mediated signal transduction" EXACT []
synonym: "stimulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "upregulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" EXACT []
is_a: GO:0075082 ! positive regulation by host of symbiont transmembrane receptor-mediated signal transduction
is_a: GO:0075084 ! modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction
is_a: GO:0075206 ! positive regulation by host of symbiont cAMP-mediated signal transduction

[Term]
id: GO:0075086
name: negative regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction ; GO:0075117".
synonym: "downregulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" EXACT []
synonym: "inhibition by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "negative regulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT []
is_a: GO:0075083 ! negative regulation by host of symbiont transmembrane receptor-mediated signal transduction
is_a: GO:0075084 ! modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction
is_a: GO:0075207 ! negative regulation by host of symbiont cAMP-mediated signal transduction

[Term]
id: GO:0075087
name: modulation by host of symbiont G-protein coupled receptor protein signal transduction
namespace: biological_process
def: "Any process by which the host organism modulates the frequency, rate or extent of the symbiont G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host G-protein coupled receptor protein signal transduction ; GO:0075118".
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075081 ! modulation by host of symbiont transmembrane receptor-mediated signal transduction

[Term]
id: GO:0075088
name: positive regulation by host of symbiont G-protein coupled receptor protein signal transduction
namespace: biological_process
def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host G-protein coupled receptor protein signal transduction ; GO:0075119".
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075082 ! positive regulation by host of symbiont transmembrane receptor-mediated signal transduction
is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075089
name: negative regulation by host of symbiont G-protein coupled receptor protein signal transduction
namespace: biological_process
def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of the symbiont G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host G-protein coupled receptor protein signal transduction ; GO:0075120".
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075083 ! negative regulation by host of symbiont transmembrane receptor-mediated signal transduction
is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075090
name: modulation by host of symbiont signal transduction mediated by G-protein alpha subunit
namespace: biological_process
def: "Any process by which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host signal transduction mediated by G-protein alpha subunit ; GO:0075121".
is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075091
name: positive regulation by host of symbiont signal transduction mediated by G-protein alpha subunit
namespace: biological_process
def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host signal transduction mediated by G-protein alpha subunit ; GO:0075122".
is_a: GO:0075088 ! positive regulation by host of symbiont G-protein coupled receptor protein signal transduction
is_a: GO:0075090 ! modulation by host of symbiont signal transduction mediated by G-protein alpha subunit

[Term]
id: GO:0075092
name: negative regulation by host of symbiont signal transduction mediated by G-protein alpha subunit
namespace: biological_process
def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host signal transduction mediated by G-protein alpha subunit ; GO:0075123".
is_a: GO:0075089 ! negative regulation by host of symbiont G-protein coupled receptor protein signal transduction
is_a: GO:0075090 ! modulation by host of symbiont signal transduction mediated by G-protein alpha subunit

[Term]
id: GO:0075093
name: modulation by host of symbiont signal transduction mediated by G-protein beta subunit
namespace: biological_process
def: "Any process by which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host signal transduction mediated by G-protein beta subunit ; GO:0075124".
is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075094
name: positive regulation by host of symbiont signal transduction mediated by G-protein beta subunit
namespace: biological_process
def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host signal transduction mediated by G-protein beta subunit ; GO:0075125".
is_a: GO:0075088 ! positive regulation by host of symbiont G-protein coupled receptor protein signal transduction
is_a: GO:0075093 ! modulation by host of symbiont signal transduction mediated by G-protein beta subunit

[Term]
id: GO:0075095
name: negative regulation by host of symbiont signal transduction mediated by G-protein beta subunit
namespace: biological_process
def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host signal transduction mediated by G-protein beta subunit ; GO:0075126".
is_a: GO:0075089 ! negative regulation by host of symbiont G-protein coupled receptor protein signal transduction
is_a: GO:0075093 ! modulation by host of symbiont signal transduction mediated by G-protein beta subunit

[Term]
id: GO:0075096
name: modulation by host of symbiont signal transduction mediated by G-protein gamma subunit
namespace: biological_process
def: "Any process by which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host signal transduction mediated by G-protein gamma subunit ; GO:0075127".
is_a: GO:0075087 ! modulation by host of symbiont G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075097
name: positive regulation by host of symbiont signal transduction mediated by G-protein gamma subunit
namespace: biological_process
def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host signal transduction mediated by G-protein gamma subunit ; GO:0075128".
is_a: GO:0075088 ! positive regulation by host of symbiont G-protein coupled receptor protein signal transduction
is_a: GO:0075096 ! modulation by host of symbiont signal transduction mediated by G-protein gamma subunit

[Term]
id: GO:0075098
name: negative regulation by host of symbiont signal transduction mediated by G-protein gamma subunit
namespace: biological_process
def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host signal transduction mediated by G-protein gamma subunit ; GO:0075129".
is_a: GO:0075089 ! negative regulation by host of symbiont G-protein coupled receptor protein signal transduction
is_a: GO:0075096 ! modulation by host of symbiont signal transduction mediated by G-protein gamma subunit

[Term]
id: GO:0075099
name: modulation by host of symbiont protein kinase-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host protein kinase-mediated signal transduction ; GO:0075130".
is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway

[Term]
id: GO:0075100
name: positive regulation by host of symbiont protein kinase-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host protein kinase-mediated signal transduction ; GO:0075131".
is_a: GO:0075099 ! modulation by host of symbiont protein kinase-mediated signal transduction

[Term]
id: GO:0075101
name: negative regulation by host of symbiont protein kinase-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host protein kinase-mediated signal transduction ; GO:0075132".
is_a: GO:0075099 ! modulation by host of symbiont protein kinase-mediated signal transduction

[Term]
id: GO:0075102
name: negative regulation by host of symbiont MAP kinase-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of the symbiont MAP kinase-mediated signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host MAP kinase-mediated signal transduction pathway ; GO:0052078".
is_a: GO:0052435 ! modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway
is_a: GO:0075101 ! negative regulation by host of symbiont protein kinase-mediated signal transduction

[Term]
id: GO:0075103
name: modulation by host of symbiont calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism modulates the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host calcium or calmodulin-mediated signal transduction ; GO:0075133".
synonym: "modulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT []
is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway

[Term]
id: GO:0075104
name: positive regulation by host of symbiont calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host calcium or calmodulin-mediated signal transduction ; GO:0075134".
synonym: "positive regulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT []
is_a: GO:0052525 ! positive regulation by host of symbiont signal transduction pathway
is_a: GO:0075103 ! modulation by host of symbiont calcium or calmodulin-mediated signal transduction

[Term]
id: GO:0075105
name: negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host calcium or calmodulin-mediated signal transduction ; GO:0075135".
synonym: "negative regulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT []
is_a: GO:0052492 ! negative regulation by host of symbiont signal transduction pathway
is_a: GO:0075103 ! modulation by host of symbiont calcium or calmodulin-mediated signal transduction

[Term]
id: GO:0075106
name: modulation by symbiont of host adenylate cyclase activity
namespace: biological_process
def: "Any process by which the symbiont modulates the frequency, rate or extent of the host adenylate cyclase activity, which involves catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont adenylate cyclase activity ; GO:0075075".
synonym: "Modulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT []
synonym: "Modulation by symbiont of host adenyl cyclase activity" EXACT []
synonym: "Modulation by symbiont of host adenylyl cyclase activity" EXACT []
synonym: "Modulation by symbiont of host adenylylcyclase activity" EXACT []
synonym: "Modulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT []
synonym: "Modulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT []
synonym: "Modulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT []
synonym: "Modulation by symbiont of host cAMP generating peptide activity" RELATED []
is_a: GO:0045761 ! regulation of adenylate cyclase activity
is_a: GO:0052148 ! modulation by symbiont of host catalytic activity

[Term]
id: GO:0075107
name: positive regulation by symbiont of host adenylate cyclase activity
namespace: biological_process
def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of the host adenylate cyclase activity, which involves catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont adenylate cyclase activity ; GO:0075076".
synonym: "Positive regulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT []
synonym: "Positive regulation by symbiont of host adenyl cyclase activity" EXACT []
synonym: "Positive regulation by symbiont of host adenylyl cyclase activity" EXACT []
synonym: "Positive regulation by symbiont of host adenylylcyclase activity" EXACT []
synonym: "Positive regulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT []
synonym: "Positive regulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT []
synonym: "Positive regulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT []
synonym: "Positive regulation by symbiont of host cAMP generating peptide activity" RELATED []
is_a: GO:0043948 ! positive regulation by symbiont of host catalytic activity
is_a: GO:0045762 ! positive regulation of adenylate cyclase activity
is_a: GO:0075106 ! modulation by symbiont of host adenylate cyclase activity

[Term]
id: GO:0075108
name: negative regulation by symbiont of host adenylate cyclase activity
namespace: biological_process
def: "Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of the host adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont adenylate cyclase activity ; GO:0075077".
synonym: "Negative regulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT []
synonym: "Negative regulation by symbiont of host adenyl cyclase activity" EXACT []
synonym: "Negative regulation by symbiont of host adenylyl cyclase activity" EXACT []
synonym: "Negative regulation by symbiont of host adenylylcyclase activity" EXACT []
synonym: "Negative regulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT []
synonym: "Negative regulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT []
synonym: "Negative regulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT []
synonym: "Negative regulation by symbiont of host cAMP generating peptide activity" RELATED []
is_a: GO:0007194 ! negative regulation of adenylate cyclase activity
is_a: GO:0052053 ! negative regulation by symbiont of host catalytic activity
is_a: GO:0075106 ! modulation by symbiont of host adenylate cyclase activity

[Term]
id: GO:0075109
name: modulation by symbiont of host receptor-mediated signal transduction
namespace: biological_process
def: "Any process by which the symbiont modulates the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont receptor-mediated signal transduction ; GO:0075078".
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway

[Term]
id: GO:0075110
name: positive regulation by symbiont of host receptor-mediated signal transduction
namespace: biological_process
def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont receptor-mediated signal transduction ; GO:0075079".
is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway
is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction

[Term]
id: GO:0075111
name: negative regulation by symbiont of host receptor-mediated signal transduction
namespace: biological_process
def: "Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont receptor-mediated signal transduction ; GO:0075080".
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway
is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction

[Term]
id: GO:0075112
name: modulation by symbiont of host transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "Any process by which the symbiont modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075081".
is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction

[Term]
id: GO:0075113
name: positive regulation by symbiont of host transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075082".
is_a: GO:0075110 ! positive regulation by symbiont of host receptor-mediated signal transduction
is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction

[Term]
id: GO:0075114
name: negative regulation by symbiont of host transmembrane receptor-mediated signal transduction
namespace: biological_process
def: "Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075083".
is_a: GO:0075111 ! negative regulation by symbiont of host receptor-mediated signal transduction
is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction

[Term]
id: GO:0075115
name: modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "Any process by which the symbiont modulates the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction ; GO:0075084".
synonym: "modulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT []
is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction
is_a: GO:0075208 ! modulation by symbiont of host cAMP-mediated signal transduction

[Term]
id: GO:0075116
name: positive regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction ; GO:0075085".
synonym: "activation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "positive regulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT []
synonym: "promotion by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT []
synonym: "stimulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "upregulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT []
is_a: GO:0075113 ! positive regulation by symbiont of host transmembrane receptor-mediated signal transduction
is_a: GO:0075115 ! modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction
is_a: GO:0075209 ! positive regulation by symbiont of host cAMP-mediated signal transduction

[Term]
id: GO:0075117
name: negative regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction
namespace: biological_process
def: "Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction ; GO:0075086".
synonym: "downregulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT []
synonym: "inhibition by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW []
synonym: "negative regulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT []
is_a: GO:0075114 ! negative regulation by symbiont of host transmembrane receptor-mediated signal transduction
is_a: GO:0075115 ! modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction
is_a: GO:0075210 ! negative regulation by symbiont of host cAMP-mediated signal transduction

[Term]
id: GO:0075118
name: modulation by symbiont of host G-protein coupled receptor protein signal transduction
namespace: biological_process
def: "Any process by which the symbiont modulates the frequency, rate or extent of the host G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont G-protein coupled receptor protein signal transduction ; GO:0075087".
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction

[Term]
id: GO:0075119
name: positive regulation by symbiont of host G-protein coupled receptor protein signal transduction
namespace: biological_process
def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of the host G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by symbiont of host G-protein coupled receptor protein signal transduction ; GO:0075088".
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075113 ! positive regulation by symbiont of host transmembrane receptor-mediated signal transduction
is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075120
name: negative regulation by symbiont of host G-protein coupled receptor protein signal transduction
namespace: biological_process
def: "Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of the host G-protein coupled receptor protein signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont G-protein coupled receptor protein signal transduction ; GO:0075089".
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075114 ! negative regulation by symbiont of host transmembrane receptor-mediated signal transduction
is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075121
name: modulation by symbiont of host signal transduction mediated by G-protein alpha subunit
namespace: biological_process
def: "Any process by which the symbiont modulates the frequency, rate or extent of the host signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont signal transduction mediated by G-protein alpha subunit ; GO:0075090".
is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075122
name: positive regulation by symbiont of host signal transduction mediated by G-protein alpha subunit
namespace: biological_process
def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of the host signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont signal transduction mediated by G-protein alpha subunit ; GO:0075091".
is_a: GO:0075119 ! positive regulation by symbiont of host G-protein coupled receptor protein signal transduction
is_a: GO:0075121 ! modulation by symbiont of host signal transduction mediated by G-protein alpha subunit

[Term]
id: GO:0075123
name: negative regulation by symbiont of host signal transduction mediated by G-protein alpha subunit
namespace: biological_process
def: "Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of the host signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont signal transduction mediated by G-protein alpha subunit ; GO:0075092".
is_a: GO:0075120 ! negative regulation by symbiont of host G-protein coupled receptor protein signal transduction
is_a: GO:0075121 ! modulation by symbiont of host signal transduction mediated by G-protein alpha subunit

[Term]
id: GO:0075124
name: modulation by symbiont of host signal transduction mediated by G-protein beta subunit
namespace: biological_process
def: "Any process by which the symbiont modulates the frequency, rate or extent of the host signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont signal transduction mediated by G-protein beta subunit ; GO:0075093".
is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075125
name: positive regulation by symbiont of host signal transduction mediated by G-protein beta subunit
namespace: biological_process
def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of the host signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont signal transduction mediated by G-protein beta subunit ; GO:0075094".
is_a: GO:0075119 ! positive regulation by symbiont of host G-protein coupled receptor protein signal transduction
is_a: GO:0075124 ! modulation by symbiont of host signal transduction mediated by G-protein beta subunit

[Term]
id: GO:0075126
name: negative regulation by symbiont of host signal transduction mediated by G-protein beta subunit
namespace: biological_process
def: "Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of the host signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont signal transduction mediated by G-protein beta subunit ; GO:0075095".
is_a: GO:0075120 ! negative regulation by symbiont of host G-protein coupled receptor protein signal transduction
is_a: GO:0075124 ! modulation by symbiont of host signal transduction mediated by G-protein beta subunit

[Term]
id: GO:0075127
name: modulation by symbiont of host signal transduction mediated by G-protein gamma subunit
namespace: biological_process
def: "Any process by which the symbiont modulates the frequency, rate or extent of the host signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont signal transduction mediated by G-protein gamma subunit ; GO:0075096".
is_a: GO:0075118 ! modulation by symbiont of host G-protein coupled receptor protein signal transduction

[Term]
id: GO:0075128
name: positive regulation by symbiont of host signal transduction mediated by G-protein gamma subunit
namespace: biological_process
def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of the host signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont signal transduction mediated by G-protein gamma subunit ; GO:0075097".
is_a: GO:0075119 ! positive regulation by symbiont of host G-protein coupled receptor protein signal transduction
is_a: GO:0075127 ! modulation by symbiont of host signal transduction mediated by G-protein gamma subunit

[Term]
id: GO:0075129
name: negative regulation by symbiont of host signal transduction mediated by G-protein gamma subunit
namespace: biological_process
def: "Any process by which the symbiont stops, prevents or reduces the frequency, rate or extent of the host signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont signal transduction mediated by G-protein gamma subunit ; GO:0075098".
is_a: GO:0075120 ! negative regulation by symbiont of host G-protein coupled receptor protein signal transduction
is_a: GO:0075127 ! modulation by symbiont of host signal transduction mediated by G-protein gamma subunit

[Term]
id: GO:0075130
name: modulation by symbiont of host protein kinase-mediated signal transduction
namespace: biological_process
def: "Any process by which the symbiont modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075099".
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway

[Term]
id: GO:0075131
name: positive regulation by symbiont of host protein kinase-mediated signal transduction
namespace: biological_process
def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075100".
is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway
is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction

[Term]
id: GO:0075132
name: negative regulation by symbiont of host protein kinase-mediated signal transduction
namespace: biological_process
def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075101".
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway
is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction

[Term]
id: GO:0075133
name: modulation by symbiont of host calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "Any process by which the symbiont modulates the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075103".
synonym: "modulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT []
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway

[Term]
id: GO:0075134
name: positive regulation by symbiont of host calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075104".
synonym: "positive regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT []
is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway
is_a: GO:0075133 ! modulation by symbiont of host calcium or calmodulin-mediated signal transduction

[Term]
id: GO:0075135
name: negative regulation by symbiont of host calcium or calmodulin-mediated signal transduction
namespace: biological_process
def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "Negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075105".
synonym: "negative regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT []
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway
is_a: GO:0075133 ! modulation by symbiont of host calcium or calmodulin-mediated signal transduction

[Term]
id: GO:0075136
name: response to host
namespace: biological_process
def: "A change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
subset: gosubset_prok
synonym: "response of symbiont to host" RELATED []
is_a: GO:0051701 ! interaction with host
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0075137
name: response to host redox environment
namespace: biological_process
def: "A change in state or activity of the symbiont organism or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the redox environment in host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "response of symbiont to host redox environment" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075138
name: response to host oxygen tension environment
namespace: biological_process
def: "A change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting oxygen tension in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "response of symbiont to host oxygen tension environment" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075139
name: response to host iron concentration
namespace: biological_process
def: "A change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting iron concentration in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "response of symbiont to host iron concentration" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075140
name: response to host defense molecules
namespace: biological_process
def: "A change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting host defense molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "response of symbiont to host defense molecules" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075141
name: maintenance of symbiont tolerance to host environment
namespace: biological_process
def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against the components of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075142
name: maintenance of symbiont tolerance to host oxygen tension environment
namespace: biological_process
def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against oxygen tension environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075138 ! response to host oxygen tension environment
is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment

[Term]
id: GO:0075143
name: maintenance of symbiont tolerance to host redox environment
namespace: biological_process
def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against redox environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075137 ! response to host redox environment
is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment

[Term]
id: GO:0075144
name: maintenance of symbiont tolerance to host iron concentration
namespace: biological_process
def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against iron concentration environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075139 ! response to host iron concentration
is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment

[Term]
id: GO:0075145
name: maintenance of symbiont tolerance to host defense molecules
namespace: biological_process
def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against defense molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075140 ! response to host defense molecules
is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment

[Term]
id: GO:0075146
name: maintenance of symbiont tolerance to host osmotic environment
namespace: biological_process
def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against osmotic environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075000 ! response to host osmotic environment
is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment

[Term]
id: GO:0075147
name: regulation of signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont signal transduction in response to host" EXACT []
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075148
name: positive regulation of signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont signal transduction in response to host" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0075147 ! regulation of signal transduction in response to host

[Term]
id: GO:0075149
name: negative regulation of signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont signal transduction in response to host" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0075147 ! regulation of signal transduction in response to host

[Term]
id: GO:0075150
name: regulation of receptor-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont receptor-mediated signal transduction in response to host" EXACT []
is_a: GO:0075147 ! regulation of signal transduction in response to host

[Term]
id: GO:0075151
name: positive regulation of receptor-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont receptor-mediated signal transduction in response to host" EXACT []
is_a: GO:0075148 ! positive regulation of signal transduction in response to host
is_a: GO:0075150 ! regulation of receptor-mediated signal transduction in response to host

[Term]
id: GO:0075152
name: negative regulation of receptor-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont receptor-mediated signal transduction in response to host" EXACT []
is_a: GO:0075149 ! negative regulation of signal transduction in response to host
is_a: GO:0075150 ! regulation of receptor-mediated signal transduction in response to host

[Term]
id: GO:0075153
name: regulation of transmembrane receptor-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT []
is_a: GO:0075150 ! regulation of receptor-mediated signal transduction in response to host

[Term]
id: GO:0075154
name: positive regulation of transmembrane receptor-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT []
is_a: GO:0075151 ! positive regulation of receptor-mediated signal transduction in response to host
is_a: GO:0075153 ! regulation of transmembrane receptor-mediated signal transduction in response to host

[Term]
id: GO:0075155
name: negative regulation of transmembrane receptor-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT []
is_a: GO:0075152 ! negative regulation of receptor-mediated signal transduction in response to host
is_a: GO:0075153 ! regulation of transmembrane receptor-mediated signal transduction in response to host

[Term]
id: GO:0075156
name: regulation of G-protein coupled receptor protein signaling pathway in response to host
namespace: biological_process
def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its G-protein coupled receptor protein-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT []
is_a: GO:0008277 ! regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075153 ! regulation of transmembrane receptor-mediated signal transduction in response to host

[Term]
id: GO:0075157
name: positive regulation of G-protein coupled receptor protein signaling pathway in response to host
namespace: biological_process
def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein coupled receptor protein-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT []
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075154 ! positive regulation of transmembrane receptor-mediated signal transduction in response to host
is_a: GO:0075156 ! regulation of G-protein coupled receptor protein signaling pathway in response to host

[Term]
id: GO:0075158
name: negative regulation of G-protein coupled receptor protein signaling pathway in response to host
namespace: biological_process
def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont G-protein coupled receptor protein-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT []
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0075155 ! negative regulation of transmembrane receptor-mediated signal transduction in response to host
is_a: GO:0075156 ! regulation of G-protein coupled receptor protein signaling pathway in response to host

[Term]
id: GO:0075159
name: regulation of G-protein alpha subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075156 ! regulation of G-protein coupled receptor protein signaling pathway in response to host

[Term]
id: GO:0075160
name: positive regulation of G-protein alpha subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075157 ! positive regulation of G-protein coupled receptor protein signaling pathway in response to host
is_a: GO:0075159 ! regulation of G-protein alpha subunit-mediated signal transduction in response to host

[Term]
id: GO:0075161
name: negative regulation of G-protein alpha subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075158 ! negative regulation of G-protein coupled receptor protein signaling pathway in response to host
is_a: GO:0075159 ! regulation of G-protein alpha subunit-mediated signal transduction in response to host

[Term]
id: GO:0075162
name: regulation of G-protein beta subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075156 ! regulation of G-protein coupled receptor protein signaling pathway in response to host

[Term]
id: GO:0075163
name: positive regulation of G-protein beta subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075157 ! positive regulation of G-protein coupled receptor protein signaling pathway in response to host
is_a: GO:0075162 ! regulation of G-protein beta subunit-mediated signal transduction in response to host

[Term]
id: GO:0075164
name: negative regulation of G-protein beta subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075158 ! negative regulation of G-protein coupled receptor protein signaling pathway in response to host
is_a: GO:0075162 ! regulation of G-protein beta subunit-mediated signal transduction in response to host

[Term]
id: GO:0075165
name: regulation of G-protein gamma subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075156 ! regulation of G-protein coupled receptor protein signaling pathway in response to host

[Term]
id: GO:0075166
name: positive regulation of G-protein gamma subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075157 ! positive regulation of G-protein coupled receptor protein signaling pathway in response to host
is_a: GO:0075165 ! regulation of G-protein gamma subunit-mediated signal transduction in response to host

[Term]
id: GO:0075167
name: negative regulation of G-protein gamma subunit-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT []
is_a: GO:0075158 ! negative regulation of G-protein coupled receptor protein signaling pathway in response to host
is_a: GO:0075165 ! regulation of G-protein gamma subunit-mediated signal transduction in response to host

[Term]
id: GO:0075168
name: regulation of protein kinase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont protein kinase-mediated signal transduction in response to host" EXACT []
is_a: GO:0075147 ! regulation of signal transduction in response to host

[Term]
id: GO:0075169
name: positive regulation of symbiont protein kinase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075148 ! positive regulation of signal transduction in response to host
is_a: GO:0075168 ! regulation of protein kinase-mediated signal transduction in response to host

[Term]
id: GO:0075170
name: negative regulation of protein kinase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont protein kinase-mediated signal transduction in response to host" EXACT []
is_a: GO:0075149 ! negative regulation of signal transduction in response to host
is_a: GO:0075168 ! regulation of protein kinase-mediated signal transduction in response to host

[Term]
id: GO:0075171
name: regulation of MAP kinase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT []
is_a: GO:0075168 ! regulation of protein kinase-mediated signal transduction in response to host

[Term]
id: GO:0075172
name: positive regulation of MAP kinase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT []
is_a: GO:0075169 ! positive regulation of symbiont protein kinase-mediated signal transduction in response to host
is_a: GO:0075171 ! regulation of MAP kinase-mediated signal transduction in response to host

[Term]
id: GO:0075173
name: negative regulation of MAP kinase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT []
is_a: GO:0075170 ! negative regulation of protein kinase-mediated signal transduction in response to host
is_a: GO:0075171 ! regulation of MAP kinase-mediated signal transduction in response to host

[Term]
id: GO:0075174
name: regulation of cAMP-mediated signaling in response to host
namespace: biological_process
def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of cAMP-mediated signal transduction in response to host" EXACT []
synonym: "regulation of cAMP-mediated signalling in response to host" EXACT []
synonym: "regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT []
is_a: GO:0043949 ! regulation of cAMP-mediated signaling
is_a: GO:0075147 ! regulation of signal transduction in response to host

[Term]
id: GO:0075175
name: positive regulation of cAMP-mediated signaling in response to host
namespace: biological_process
def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of cAMP-mediated signal transduction in response to host" EXACT []
synonym: "positive regulation of cAMP-mediated signalling in response to host" EXACT []
synonym: "positive regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT []
is_a: GO:0075148 ! positive regulation of signal transduction in response to host
is_a: GO:0075174 ! regulation of cAMP-mediated signaling in response to host

[Term]
id: GO:0075176
name: negative regulation of cAMP-mediated signaling in response to host
namespace: biological_process
def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of cAMP-mediated signal transduction in response to host" EXACT []
synonym: "negative regulation of cAMP-mediated signalling in response to host" EXACT []
synonym: "negative regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT []
is_a: GO:0043951 ! negative regulation of cAMP-mediated signaling
is_a: GO:0075149 ! negative regulation of signal transduction in response to host
is_a: GO:0075174 ! regulation of cAMP-mediated signaling in response to host

[Term]
id: GO:0075177
name: regulation of calcium or calmodulin-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "modulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT []
synonym: "modulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT []
is_a: GO:0075147 ! regulation of signal transduction in response to host

[Term]
id: GO:0075178
name: positive regulation of calcium or calmodulin-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT []
synonym: "positive regulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT []
is_a: GO:0075148 ! positive regulation of signal transduction in response to host
is_a: GO:0075177 ! regulation of calcium or calmodulin-mediated signal transduction in response to host

[Term]
id: GO:0075179
name: negative regulation of calcium or calmodulin-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT []
synonym: "negative regulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT []
is_a: GO:0075149 ! negative regulation of signal transduction in response to host
is_a: GO:0075177 ! regulation of calcium or calmodulin-mediated signal transduction in response to host

[Term]
id: GO:0075180
name: regulation of transcription in response to host
namespace: biological_process
def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont transcription in response to host" EXACT []
is_a: GO:0045449 ! regulation of transcription
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075181
name: positive regulation of symbiont transcription in response to host
namespace: biological_process
def: "Any process by which an organism activates, maintains or increases the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0045941 ! positive regulation of transcription
is_a: GO:0075180 ! regulation of transcription in response to host

[Term]
id: GO:0075182
name: negative regulation of symbiont transcription in response to host
namespace: biological_process
def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0016481 ! negative regulation of transcription
is_a: GO:0075180 ! regulation of transcription in response to host

[Term]
id: GO:0075183
name: infection cushion formation on or near host
namespace: biological_process
def: "The process by which an organized mass of hyphae is formed on or near the host organism, and numerous infective hyphae develop from the hyphae mass. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075015 ! formation of infection structure on or near host

[Term]
id: GO:0075184
name: regulation of infection cushion formation on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
relationship: regulates GO:0075183 ! infection cushion formation on or near host

[Term]
id: GO:0075185
name: positive regulation of infection cushion formation on or near host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044149 ! positive regulation of development of symbiont during interaction with host
is_a: GO:0075184 ! regulation of infection cushion formation on or near host
relationship: positively_regulates GO:0075183 ! infection cushion formation on or near host

[Term]
id: GO:0075186
name: negative regulation of infection cushion formation on or near host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044147 ! negative regulation of development of symbiont during interaction with host
is_a: GO:0075184 ! regulation of infection cushion formation on or near host
relationship: negatively_regulates GO:0075183 ! infection cushion formation on or near host

[Term]
id: GO:0075187
name: hyphopodium formation on or near host
namespace: biological_process
def: "The process by which a specialized structure, consisted of stalked, thick-walled, lobed cells of vegetative epiphytic hyphae, is formed, to attach and penetrate the host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075015 ! formation of infection structure on or near host

[Term]
id: GO:0075188
name: regulation of hyphopodium formation on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044138 ! modulation of development of symbiont on or near host
relationship: regulates GO:0075187 ! hyphopodium formation on or near host

[Term]
id: GO:0075189
name: positive regulation of hyphopodium formation on or near host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface
is_a: GO:0075188 ! regulation of hyphopodium formation on or near host
relationship: positively_regulates GO:0075187 ! hyphopodium formation on or near host

[Term]
id: GO:0075190
name: negative regulation of hyphopodium formation on or near host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface
is_a: GO:0075188 ! regulation of hyphopodium formation on or near host
relationship: negatively_regulates GO:0075187 ! hyphopodium formation on or near host

[Term]
id: GO:0075191
name: autophagy of host cells on or near symbiont surface
namespace: biological_process
def: "The process by which the host cells digest parts of their own cytoplasm, occurring when the host is on or near its symbiont surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should be used to annotate gene products of host.
is_a: GO:0075044 ! autophagy of host cells during interaction with symbiont

[Term]
id: GO:0075192
name: haustorium mother cell formation on or near host
namespace: biological_process
def: "The process by which a symbiont cell is formed on or near its host organism, via separated from the tip of an infection hypha by a septum. The haustorium mother cell usually contains 2-4 fungal nuclei, and its function is to attach and penetrate the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075015 ! formation of infection structure on or near host

[Term]
id: GO:0075193
name: regulation of haustorium mother cell formation on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont haustorium mother cell formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044138 ! modulation of development of symbiont on or near host
relationship: regulates GO:0075192 ! haustorium mother cell formation on or near host

[Term]
id: GO:0075194
name: positive regulation of haustorium mother cell formation on or near host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont haustorium mother cell formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface
is_a: GO:0075193 ! regulation of haustorium mother cell formation on or near host
relationship: positively_regulates GO:0075192 ! haustorium mother cell formation on or near host

[Term]
id: GO:0075195
name: negative regulation of haustorium mother cell formation on or near host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont haustorium mother cell formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface
is_a: GO:0075193 ! regulation of haustorium mother cell formation on or near host
relationship: negatively_regulates GO:0075192 ! haustorium mother cell formation on or near host

[Term]
id: GO:0075196
name: adhesion of symbiont haustorium mother cell to host
namespace: biological_process
def: "The attachment of a haustorium mother cell of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: " adhesion of symbiont haustorium mother cell to host during symbiotic interaction" EXACT []
is_a: GO:0075001 ! adhesion of symbiont infection structure to host

[Term]
id: GO:0075197
name: formation of symbiont haustorium neck for entry into host
namespace: biological_process
def: "The assembly by the symbiont of a neck-like structure for the purpose of penetration into its host organism. The neck-like structure connects haustorium mother cell and haustorium. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "symbiont haustorium neck formation for entry into host" EXACT []
is_a: GO:0075015 ! formation of infection structure on or near host
relationship: part_of GO:0075052 ! entry into host via a specialized structure

[Term]
id: GO:0075198
name: modulation of symbiont haustorium neck formation for entry into host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044145 ! modulation of development of symbiont during interaction with host
is_a: GO:0052372 ! modulation by symbiont of entry into host
relationship: regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host

[Term]
id: GO:0075199
name: positive regulation of symbiont haustorium neck formation for entry into host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0044149 ! positive regulation of development of symbiont during interaction with host
is_a: GO:0075198 ! modulation of symbiont haustorium neck formation for entry into host
is_a: GO:0075294 ! positive regulation by symbiont of entry into host
relationship: positively_regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host

[Term]
id: GO:0075200
name: negative regulation of symbiont haustorium neck formation for entry into host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0044147 ! negative regulation of development of symbiont during interaction with host
is_a: GO:0052374 ! negative regulation by symbiont of entry into host
is_a: GO:0075198 ! modulation of symbiont haustorium neck formation for entry into host
relationship: negatively_regulates GO:0075197 ! formation of symbiont haustorium neck for entry into host

[Term]
id: GO:0075201
name: formation of symbiont penetration hypha for entry into host
namespace: biological_process
def: "The assembly by the symbiont of a threadlike, tubular structure, which may contain multiple nuclei and may or may not be divided internally by septa or cross-walls, for the purpose of penetration into its host organism. In the case of an appressorium existing, this term is defined in further details as the process by which the symbiont penetration peg expands to form a hypha which traverses the epidermal cell and emerges into the intercellular space of the mesophyll tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "symbiont penetration hypha formation for entry into host" EXACT []
is_a: GO:0075015 ! formation of infection structure on or near host
relationship: part_of GO:0075052 ! entry into host via a specialized structure

[Term]
id: GO:0075202
name: modulation of symbiont penetration hypha formation for entry into host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044145 ! modulation of development of symbiont during interaction with host
is_a: GO:0052372 ! modulation by symbiont of entry into host
relationship: regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host

[Term]
id: GO:0075203
name: positive regulation of symbiont penetration hypha formation for entry into host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0044149 ! positive regulation of development of symbiont during interaction with host
is_a: GO:0075202 ! modulation of symbiont penetration hypha formation for entry into host
is_a: GO:0075294 ! positive regulation by symbiont of entry into host
relationship: positively_regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host

[Term]
id: GO:0075204
name: negative regulation of symbiont penetration hypha formation for entry into host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0044147 ! negative regulation of development of symbiont during interaction with host
is_a: GO:0052374 ! negative regulation by symbiont of entry into host
is_a: GO:0075202 ! modulation of symbiont penetration hypha formation for entry into host
relationship: negatively_regulates GO:0075201 ! formation of symbiont penetration hypha for entry into host

[Term]
id: GO:0075205
name: modulation by host of symbiont cAMP-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism modulates the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The cAMP-mediated signal transduction is defined as a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host cAMP-mediated signal transduction ; GO:0075208".
synonym: "modulation by host of symbiont cAMP-mediated signaling" RELATED []
synonym: "modulation by host of symbiont cAMP-mediated signalling" EXACT []
synonym: "regulation by host of symbiont cAMP-mediated signaling" EXACT []
is_a: GO:0043949 ! regulation of cAMP-mediated signaling
is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway

[Term]
id: GO:0075206
name: positive regulation by host of symbiont cAMP-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host cAMP-mediated signal transduction ; GO:0075209".
synonym: "positive regulation by host of symbiont cAMP-mediated signaling" EXACT []
is_a: GO:0043950 ! positive regulation of cAMP-mediated signaling
is_a: GO:0052525 ! positive regulation by host of symbiont signal transduction pathway
is_a: GO:0075205 ! modulation by host of symbiont cAMP-mediated signal transduction

[Term]
id: GO:0075207
name: negative regulation by host of symbiont cAMP-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism stops, prevents or reduces the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "negative regulation by symbiont of host cAMP-mediated signal transduction ; GO:0075210".
synonym: "negative regulation by host of symbiont cAMP-mediated signaling" EXACT []
is_a: GO:0043951 ! negative regulation of cAMP-mediated signaling
is_a: GO:0052492 ! negative regulation by host of symbiont signal transduction pathway
is_a: GO:0075205 ! modulation by host of symbiont cAMP-mediated signal transduction

[Term]
id: GO:0075208
name: modulation by symbiont of host cAMP-mediated signal transduction
namespace: biological_process
def: "Any process by which the symbiont modulates the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont cAMP-mediated signal transduction ; GO:0075205".
synonym: "modulation by symbiont of host cAMP-mediated signaling" EXACT []
is_a: GO:0043949 ! regulation of cAMP-mediated signaling
is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway

[Term]
id: GO:0075209
name: positive regulation by symbiont of host cAMP-mediated signal transduction
namespace: biological_process
def: "Any process by which the symbiont activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont cAMP-mediated signal transduction ; GO:0075206".
synonym: "positive regulation by symbiont of host cAMP-mediated signaling" EXACT []
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0052028 ! positive regulation by symbiont of host signal transduction pathway
is_a: GO:0075208 ! modulation by symbiont of host cAMP-mediated signal transduction

[Term]
id: GO:0075210
name: negative regulation by symbiont of host cAMP-mediated signal transduction
namespace: biological_process
def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "Negative regulation by host of symbiont cAMP-mediated signal transduction ; GO:0075207".
synonym: "negative regulation by symbiont of host cAMP-mediated signaling" EXACT []
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0052029 ! negative regulation by symbiont of host signal transduction pathway
is_a: GO:0075208 ! modulation by symbiont of host cAMP-mediated signal transduction

[Term]
id: GO:0075211
name: regulation of transmembrane receptor-mediated cAMP signaling in response to host
namespace: biological_process
def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT []
synonym: "regulation of transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT []
synonym: "regulation of transmembrane receptor-mediated cAMP signalling in response to host" EXACT []
is_a: GO:0075153 ! regulation of transmembrane receptor-mediated signal transduction in response to host
is_a: GO:0075174 ! regulation of cAMP-mediated signaling in response to host

[Term]
id: GO:0075212
name: positive regulation of transmembrane receptor-mediated cAMP signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "positive regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" RELATED []
is_a: GO:0075154 ! positive regulation of transmembrane receptor-mediated signal transduction in response to host
is_a: GO:0075175 ! positive regulation of cAMP-mediated signaling in response to host
is_a: GO:0075211 ! regulation of transmembrane receptor-mediated cAMP signaling in response to host

[Term]
id: GO:0075213
name: negative regulation of transmembrane receptor-mediated cAMP signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
synonym: "negative regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT []
is_a: GO:0075155 ! negative regulation of transmembrane receptor-mediated signal transduction in response to host
is_a: GO:0075176 ! negative regulation of cAMP-mediated signaling in response to host
is_a: GO:0075211 ! regulation of transmembrane receptor-mediated cAMP signaling in response to host

[Term]
id: GO:0075214
name: spore encystment on host
namespace: biological_process
def: "The physiological, developmental and morphological changes that occur in a symbiont spore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0044132 ! development of symbiont on or near host

[Term]
id: GO:0075215
name: modulation of spore encystment on host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0044138 ! modulation of development of symbiont on or near host
relationship: regulates GO:0075214 ! spore encystment on host

[Term]
id: GO:0075216
name: positive regulation of spore encystment on host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface
is_a: GO:0075215 ! modulation of spore encystment on host
relationship: positively_regulates GO:0075214 ! spore encystment on host

[Term]
id: GO:0075217
name: negative regulation of spore encystment on host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface
is_a: GO:0075215 ! modulation of spore encystment on host
relationship: negatively_regulates GO:0075214 ! spore encystment on host

[Term]
id: GO:0075218
name: zoospore encystment on host
namespace: biological_process
def: "The physiological, developmental and morphological changes that occur in a symbiont zoospore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0075214 ! spore encystment on host

[Term]
id: GO:0075219
name: modulation of zoospore encystment on host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0075215 ! modulation of spore encystment on host
relationship: regulates GO:0075218 ! zoospore encystment on host

[Term]
id: GO:0075220
name: positive regulation of zoospore encystment on host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0075216 ! positive regulation of spore encystment on host
is_a: GO:0075219 ! modulation of zoospore encystment on host
relationship: positively_regulates GO:0075218 ! zoospore encystment on host

[Term]
id: GO:0075221
name: negative regulation of zoospore encystment on host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0075217 ! negative regulation of spore encystment on host
is_a: GO:0075219 ! modulation of zoospore encystment on host
relationship: negatively_regulates GO:0075218 ! zoospore encystment on host

[Term]
id: GO:0075222
name: sporangium germination on or near host
namespace: biological_process
def: "The physiological, developmental and morphological changes that occur in a symbiont sporangium following release from dormancy up to the earliest signs of growth occurring on or near its host organism. A sporangium is a structure producing and containing spores. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "direct germination on or near host" NARROW []
synonym: "germination of symbiont sporangium on or near host" EXACT []
synonym: "symbiont sporangium germination on or near host" EXACT []
is_a: GO:0043582 ! sporangium development
is_a: GO:0044132 ! development of symbiont on or near host

[Term]
id: GO:0075223
name: modulation of sporangium germination on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sporangium germination. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044138 ! modulation of development of symbiont on or near host
is_a: GO:0075310 ! regulation of sporangium development
relationship: regulates GO:0075222 ! sporangium germination on or near host

[Term]
id: GO:0075224
name: positive regulation of sporangium germination on or near host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangium germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044143 ! positive regulation of development of symbiont on or near host surface
is_a: GO:0075223 ! modulation of sporangium germination on or near host
is_a: GO:0075311 ! positive regulation of sporangium development
relationship: positively_regulates GO:0075222 ! sporangium germination on or near host

[Term]
id: GO:0075225
name: negative regulation of sporangium germination on or near host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sporangium germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044141 ! negative regulation of development of symbiont on or near host surface
is_a: GO:0075223 ! modulation of sporangium germination on or near host
is_a: GO:0075312 ! negative regulation of sporangium development
relationship: negatively_regulates GO:0075222 ! sporangium germination on or near host

[Term]
id: GO:0075226
name: encysted zoospore germination on or near host
namespace: biological_process
def: "The physiological, developmental and morphological changes that occur in the symbiont encysted zoospore, which is on or near its host organism and germinates by developing a germ tube that may penetrate the host directly or indirectly through an appresorium. An encysted zoospore is a zoospore which has shed its flagellum and whose membrane has fused to form a walled cyst. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075005 ! spore germination on or near host

[Term]
id: GO:0075227
name: modulation of encysted zoospore germination on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of encysted zoospore germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075006 ! modulation of spore germination on or near host
relationship: regulates GO:0075226 ! encysted zoospore germination on or near host

[Term]
id: GO:0075228
name: positive regulation of encysted zoospore germination on or near host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of encysted zoospore germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075007 ! positive regulation of spore germination on or near host
is_a: GO:0075227 ! modulation of encysted zoospore germination on or near host
relationship: positively_regulates GO:0075226 ! encysted zoospore germination on or near host

[Term]
id: GO:0075229
name: negative regulation of encysted zoospore germination on or near host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of encysted zoospore germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0075008 ! negative regulation of spore germination on or near host
is_a: GO:0075227 ! modulation of encysted zoospore germination on or near host
relationship: negatively_regulates GO:0075226 ! encysted zoospore germination on or near host

[Term]
id: GO:0075230
name: spore movement on or near host
namespace: biological_process
def: "Any process involved in the directed movement of a motile spore on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0052127 ! movement on or near host

[Term]
id: GO:0075231
name: modulation of spore movement on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0043903 ! regulation of symbiosis, encompassing mutualism through parasitism
relationship: regulates GO:0075230 ! spore movement on or near host

[Term]
id: GO:0075232
name: positive regulation of spore movement on or near host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0040017 ! positive regulation of locomotion
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0075231 ! modulation of spore movement on or near host
relationship: positively_regulates GO:0075230 ! spore movement on or near host

[Term]
id: GO:0075233
name: negative regulation of spore movement on or near host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0040013 ! negative regulation of locomotion
is_a: GO:0043901 ! negative regulation of multi-organism process
is_a: GO:0075231 ! modulation of spore movement on or near host
relationship: negatively_regulates GO:0075230 ! spore movement on or near host

[Term]
id: GO:0075234
name: zoospore movement on or near host
namespace: biological_process
def: "Any process involved in the directed movement of a zoospore on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "zoospore motility on or near host" EXACT []
is_a: GO:0075230 ! spore movement on or near host

[Term]
id: GO:0075235
name: modulation of zoospore movement on or near host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of zoospore movement on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "regulation of zoospore motility on or near host" EXACT []
is_a: GO:0075231 ! modulation of spore movement on or near host
relationship: regulates GO:0075234 ! zoospore movement on or near host

[Term]
id: GO:0075236
name: positive regulation of zoospore movement on or near host
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0075232 ! positive regulation of spore movement on or near host
is_a: GO:0075235 ! modulation of zoospore movement on or near host
relationship: positively_regulates GO:0075234 ! zoospore movement on or near host

[Term]
id: GO:0075237
name: negative regulation of zoospore movement on or near host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of zoospore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0075233 ! negative regulation of spore movement on or near host
is_a: GO:0075235 ! modulation of zoospore movement on or near host
relationship: negatively_regulates GO:0075234 ! zoospore movement on or near host

[Term]
id: GO:0075238
name: maintenance of symbiont tolerance to host pH environment
namespace: biological_process
def: "Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against pH environment of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075141 ! maintenance of symbiont tolerance to host environment
is_a: GO:0075293 ! response to host pH environment

[Term]
id: GO:0075239
name: zoospore formation
namespace: biological_process
def: "The process by which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators]
is_a: GO:0034300 ! sporangiospore formation

[Term]
id: GO:0075240
name: regulation of zoospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of zoospore formation, a process by which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators]
is_a: GO:0075286 ! regulation of sporangiospore formation
relationship: regulates GO:0075239 ! zoospore formation

[Term]
id: GO:0075241
name: positive regulation of zoospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore formation, a process by which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators]
is_a: GO:0075240 ! regulation of zoospore formation
is_a: GO:0075287 ! positive regulation of sporangiospore formation
relationship: positively_regulates GO:0075239 ! zoospore formation

[Term]
id: GO:0075242
name: negative regulation of zoospore formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of zoospore formation, a process by which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators]
is_a: GO:0075240 ! regulation of zoospore formation
is_a: GO:0075288 ! negative regulation of sporangiospore formation
relationship: negatively_regulates GO:0075239 ! zoospore formation

[Term]
id: GO:0075243
name: oospore formation
namespace: biological_process
def: "The process by which male and female gametangia develop and fuse to form an oospore, a thick-walled resting spore of oomycetes." [GOC:pamgo_curators]
is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0075244
name: regulation of oospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oospore formation, a process by which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators]
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
relationship: regulates GO:0075243 ! oospore formation

[Term]
id: GO:0075245
name: positive regulation of oospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of oospore formation, a process by which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators]
is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075244 ! regulation of oospore formation
relationship: positively_regulates GO:0075243 ! oospore formation

[Term]
id: GO:0075246
name: negative regulation of oospore formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oospore formation, a process by which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators]
is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075244 ! regulation of oospore formation
relationship: negatively_regulates GO:0075243 ! oospore formation

[Term]
id: GO:0075247
name: aeciospore formation
namespace: biological_process
def: "The process by which a dikaryotic spore of typically a rust fungus is produced in an aecium; in heteroecious rusts, the aeciospore is a spore stage that infects the alternate host." [GOC:pamgo_curators]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0075248
name: regulation of aeciospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aeciospore formation, a process by which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators]
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
relationship: regulates GO:0075247 ! aeciospore formation

[Term]
id: GO:0075249
name: positive regulation of aeciospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of aeciospore formation, a process by which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators]
is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075248 ! regulation of aeciospore formation
relationship: positively_regulates GO:0075247 ! aeciospore formation

[Term]
id: GO:0075250
name: negative regulation of aeciospore formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aeciospore formation, a process by which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators]
is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075248 ! regulation of aeciospore formation
relationship: negatively_regulates GO:0075247 ! aeciospore formation

[Term]
id: GO:0075251
name: ureidospore formation
namespace: biological_process
def: "The process which specific outcome is the formation of an asexual, dikaryotic, often rusty-colored spore, produced in a structure called a uredinium; mostly found in the rust fungus." [GOC:pamgo_curators]
synonym: "urediniospore formation" EXACT []
synonym: "uredospore formation" EXACT []
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0075252
name: regulation of ureidospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ureidospore formation, a process by which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators]
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
relationship: regulates GO:0075251 ! ureidospore formation

[Term]
id: GO:0075253
name: positive regulation of ureidospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of ureidospore formation, a process by which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators]
is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075252 ! regulation of ureidospore formation
relationship: positively_regulates GO:0075251 ! ureidospore formation

[Term]
id: GO:0075254
name: negative regulation of ureidospore formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ureidospore formation, a process by which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators]
synonym: "teleutospore formation" EXACT []
synonym: "teleutosporodesm formation" EXACT []
is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075252 ! regulation of ureidospore formation
relationship: negatively_regulates GO:0075251 ! ureidospore formation

[Term]
id: GO:0075255
name: teliospore formation
namespace: biological_process
def: "The set of processes leading to the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators]
is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore

[Term]
id: GO:0075256
name: regulation of teliospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators]
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
relationship: regulates GO:0075255 ! teliospore formation

[Term]
id: GO:0075257
name: positive regulation of teliospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators]
is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075256 ! regulation of teliospore formation
relationship: positively_regulates GO:0075255 ! teliospore formation

[Term]
id: GO:0075258
name: negative regulation of teliospore formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators]
is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075256 ! regulation of teliospore formation
relationship: negatively_regulates GO:0075255 ! teliospore formation

[Term]
id: GO:0075259
name: spore-bearing organ development
namespace: biological_process
def: "The process whose specific outcome is the progression of a spore-bearing organ over time, from its formation to the mature structure. A spore-bearing organ is an anatomical structure that produces new spores." [GOC:mah, GOC:mcc, GOC:pamgo_curators]
synonym: "fruiting structure development" EXACT []
is_a: GO:0048513 ! organ development
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0075260
name: regulation of spore-bearing organ development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of spore-bearing organ development, a process by which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075261
name: positive regulation of spore-bearing organ development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of spore-bearing organ development, a process by which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: positively_regulates GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075262
name: negative regulation of spore-bearing organ development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of spore-bearing organ development, a process by which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: negatively_regulates GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075263
name: oogonium development
namespace: biological_process
def: "The process that leads to the development of an oogonium, a female gametangium of Oomycetes, containing one or more gametes." [GOC:pamgo_curators]
is_a: GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075264
name: regulation of oogonium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0075263 ! oogonium development

[Term]
id: GO:0075265
name: positive regulation of oogonium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075264 ! regulation of oogonium development
relationship: positively_regulates GO:0075263 ! oogonium development

[Term]
id: GO:0075266
name: negative regulation of oogonium development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075264 ! regulation of oogonium development
relationship: negatively_regulates GO:0075263 ! oogonium development

[Term]
id: GO:0075267
name: aecium development
namespace: biological_process
def: "The process by which a cup-like structure containing chains of aeciospores is formed. This is characteristic of the rust fungus and typically, the first dikaryotic spores (aeciospores) are produced in the aecium." [GOC:pamgo_curators]
is_a: GO:0030582 ! fruiting body development

[Term]
id: GO:0075268
name: regulation of aecium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aecium development, a process by which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators]
is_a: GO:0031155 ! regulation of fruiting body development
relationship: regulates GO:0075267 ! aecium development

[Term]
id: GO:0075269
name: positive regulation of aecium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of aecium development, a process by which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075268 ! regulation of aecium development
relationship: positively_regulates GO:0075267 ! aecium development

[Term]
id: GO:0075270
name: negative regulation of aecium development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aecium development, a process by which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075268 ! regulation of aecium development
relationship: negatively_regulates GO:0075267 ! aecium development

[Term]
id: GO:0075271
name: zygosporangium development
namespace: biological_process
def: "The process by which a fruiting body called zygosporangium is formed. A zygosporangium is a thick-walled structure in which spores are produced, and is characteristic of the Zygomycetes." [GOC:pamgo_curators]
is_a: GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075272
name: regulation of zygosporangium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of zygosporangium development, a process by which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0075271 ! zygosporangium development

[Term]
id: GO:0075273
name: positive regulation of zygosporangium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of zygosporangium development, a process by which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075272 ! regulation of zygosporangium development
relationship: positively_regulates GO:0075271 ! zygosporangium development

[Term]
id: GO:0075274
name: negative regulation of zygosporangium development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of zygosporangium development, a process by which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075272 ! regulation of zygosporangium development
relationship: negatively_regulates GO:0075271 ! zygosporangium development

[Term]
id: GO:0075275
name: telium development
namespace: biological_process
def: "The process that leads to the development of a telium, which is a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators]
is_a: GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075276
name: regulation of telium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0075275 ! telium development

[Term]
id: GO:0075277
name: positive regulation of telium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075276 ! regulation of telium development
relationship: positively_regulates GO:0075275 ! telium development

[Term]
id: GO:0075278
name: negative regulation of telium development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075276 ! regulation of telium development
relationship: negatively_regulates GO:0075275 ! telium development

[Term]
id: GO:0075279
name: uredinium development
namespace: biological_process
def: "The process that leads to the formation of a uredinium, a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators]
synonym: "development of uredium" EXACT []
is_a: GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075280
name: regulation of uredinium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0075279 ! uredinium development

[Term]
id: GO:0075281
name: positive regulation of uredinium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075280 ! regulation of uredinium development
relationship: positively_regulates GO:0075279 ! uredinium development

[Term]
id: GO:0075282
name: negative regulation of uredinium development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075280 ! regulation of uredinium development
relationship: negatively_regulates GO:0075279 ! uredinium development

[Term]
id: GO:0075283
name: sporulation resulting in formation of a multicellular or syncytial spore
namespace: biological_process
def: "The process whose specific outcome is the progression of a multicellular or syncytial spore via septations over time, from its initiation to the mature structure." [GOC:pamgo_curators]
synonym: "multicellular or syncytial spore formation by sporulation" EXACT [GOC:dph, GOC:tb]
is_a: GO:0043934 ! sporulation

[Term]
id: GO:0075284
name: asexual sporulation resulting in formation of a multicellular or syncytial spore
namespace: biological_process
def: "The formation of a multicellular or syncytial spore via septations derived from mitosis." [GOC:pamgo_curators]
is_a: GO:0030436 ! asexual sporulation
is_a: GO:0075283 ! sporulation resulting in formation of a multicellular or syncytial spore

[Term]
id: GO:0075285
name: sexual sporulation resulting in formation of a multicellular or syncytial spore
namespace: biological_process
def: "The formation of multicellular or syncytial spore via septations derived from meiosis. A multicellular or syncytial spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators]
is_a: GO:0034293 ! sexual sporulation
is_a: GO:0075283 ! sporulation resulting in formation of a multicellular or syncytial spore

[Term]
id: GO:0075286
name: regulation of sporangiospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sporangiospore formation, a process by which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators]
is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore
relationship: regulates GO:0034300 ! sporangiospore formation

[Term]
id: GO:0075287
name: positive regulation of sporangiospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangiospore formation, a process by which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators]
is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075286 ! regulation of sporangiospore formation
relationship: positively_regulates GO:0034300 ! sporangiospore formation

[Term]
id: GO:0075288
name: negative regulation of sporangiospore formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sporangiospore formation, a process by which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators]
is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore
is_a: GO:0075286 ! regulation of sporangiospore formation
relationship: negatively_regulates GO:0034300 ! sporangiospore formation

[Term]
id: GO:0075289
name: aplanospore formation
namespace: biological_process
def: "The process by which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators]
is_a: GO:0034300 ! sporangiospore formation

[Term]
id: GO:0075290
name: regulation of aplanospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of aplanospore formation, a process by which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators]
is_a: GO:0075286 ! regulation of sporangiospore formation
relationship: regulates GO:0075289 ! aplanospore formation

[Term]
id: GO:0075291
name: positive regulation of aplanospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of aplanospore formation, a process by which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators]
is_a: GO:0075287 ! positive regulation of sporangiospore formation
is_a: GO:0075290 ! regulation of aplanospore formation
relationship: positively_regulates GO:0075289 ! aplanospore formation

[Term]
id: GO:0075292
name: negative regulation of aplanospore formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of aplanospore formation, a process by which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators]
is_a: GO:0075288 ! negative regulation of sporangiospore formation
is_a: GO:0075290 ! regulation of aplanospore formation
relationship: negatively_regulates GO:0075289 ! aplanospore formation

[Term]
id: GO:0075293
name: response to host pH environment
namespace: biological_process
def: "A change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "response of symbiont to host pH environment" EXACT []
is_a: GO:0075136 ! response to host

[Term]
id: GO:0075294
name: positive regulation by symbiont of entry into host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "activation by symbiont of entry into host" NARROW []
synonym: "up regulation by symbiont of entry into host" EXACT []
synonym: "up-regulation by symbiont of entry into host" EXACT []
synonym: "upregulation by symbiont of entry into host" EXACT []
is_a: GO:0052372 ! modulation by symbiont of entry into host
is_a: GO:0075295 ! positive regulation by organism of entry into other organism during symbiotic interaction

[Term]
id: GO:0075295
name: positive regulation by organism of entry into other organism during symbiotic interaction
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "activation by organism of entry into other organism during symbiotic interaction" NARROW []
synonym: "up regulation by organism of entry into other organism during symbiotic interaction" EXACT []
synonym: "up-regulation by organism of entry into other organism during symbiotic interaction" EXACT []
synonym: "upregulation by organism of entry into other organism during symbiotic interaction" EXACT []
is_a: GO:0043902 ! positive regulation of multi-organism process
is_a: GO:0052371 ! regulation by organism of entry into other organism during symbiotic interaction

[Term]
id: GO:0075296
name: positive regulation of ascospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of ascospore formation, a process by which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus." [GOC:pamgo_curators]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0034307 ! regulation of ascospore formation
is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore
relationship: positively_regulates GO:0030437 ! ascospore formation

[Term]
id: GO:0075297
name: negative regulation of ascospore formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ascospore formation, a process by which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus." [GOC:pamgo_curators]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0034307 ! regulation of ascospore formation
is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore
relationship: negatively_regulates GO:0030437 ! ascospore formation

[Term]
id: GO:0075298
name: regulation of zygospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of zygospore formation, a process by which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators]
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
relationship: regulates GO:0034296 ! zygospore formation

[Term]
id: GO:0075299
name: positive regulation of zygospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of zygospore formation, a process by which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators]
is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075298 ! regulation of zygospore formation
relationship: positively_regulates GO:0034296 ! zygospore formation

[Term]
id: GO:0075300
name: negative regulation of zygospore formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of zygospore formation, a process by which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators]
is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075298 ! regulation of zygospore formation
relationship: negatively_regulates GO:0034296 ! zygospore formation

[Term]
id: GO:0075301
name: cell differentiation involved in spore germination
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires specialized features of a specific cell type occurring during spore germination, the physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth." [GOC:jl]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0009847 ! spore germination

[Term]
id: GO:0075302
name: regulation of basidiospore formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of basidiospore formation, a process by which a sexually produced fungal spore is formed on a basidium in the fungi Basidiomycetes." [GOC:pamgo_curators]
is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore
relationship: regulates GO:0034295 ! basidiospore formation

[Term]
id: GO:0075303
name: positive regulation of basidiospore formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of basidiospore formation, a process by which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes." [GOC:pamgo_curators]
is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075302 ! regulation of basidiospore formation
relationship: positively_regulates GO:0034295 ! basidiospore formation

[Term]
id: GO:0075304
name: negative regulation of basidiospore formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of basidiospore formation, a process by which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes." [GOC:pamgo_curators]
is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore
is_a: GO:0075302 ! regulation of basidiospore formation
relationship: negatively_regulates GO:0034295 ! basidiospore formation

[Term]
id: GO:0075305
name: modulation of growth or development of symbiont on or near host
namespace: biological_process
def: "OBSOLETE. Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'modulation of growth of symbiont on or near host ; GO:0044139' and 'modulation of development of symbiont on or near host ; GO:0044138'.
synonym: "modulation of growth or development of symbiont on or near host surface" EXACT []
is_obsolete: true
replaced_by: GO:0044138
replaced_by: GO:0044139

[Term]
id: GO:0075306
name: regulation of conidium formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of conidium formation, a processes leading to the production of a type of asexual non-motile reproductive spore of fungi via mitosis at the tip or side of hyphae or on special spore-producing structures called conidiophores." [GOC:pamgo_curators]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0034305 ! regulation of asexual sporulation
relationship: regulates GO:0048315 ! conidium formation

[Term]
id: GO:0075307
name: positive regulation of conidium formation
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of conidium formation, a processes leading to the production of a type of asexual non-motile reproductive spore of fungi via mitosis at the tip or side of hyphae or on special spore-producing structures called conidiophores." [GOC:pamgo_curators]
is_a: GO:0043938 ! positive regulation of sporulation
is_a: GO:0075306 ! regulation of conidium formation
relationship: positively_regulates GO:0048315 ! conidium formation

[Term]
id: GO:0075308
name: negative regulation of conidium formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of conidium formation, a processes leading to the production of a type of asexual non-motile reproductive spore of fungi via mitosis at the tip or side of hyphae or on special spore-producing structures called conidiophores." [GOC:pamgo_curators]
is_a: GO:0043939 ! negative regulation of sporulation
is_a: GO:0075306 ! regulation of conidium formation
relationship: negatively_regulates GO:0048315 ! conidium formation

[Term]
id: GO:0075309
name: negative regulation of growth or development of symbiont on or near host surface
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of the increase in the symbiont's size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'negative regulation of development of symbiont on or near host surface ; GO:0044141' and 'negative regulation of growth of symbiont on or near host surface ; GO:0044140'.
is_obsolete: true
replaced_by: GO:0044140
replaced_by: GO:0044141

[Term]
id: GO:0075310
name: regulation of sporangium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0043582 ! sporangium development

[Term]
id: GO:0075311
name: positive regulation of sporangium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075310 ! regulation of sporangium development
relationship: positively_regulates GO:0043582 ! sporangium development

[Term]
id: GO:0075312
name: negative regulation of sporangium development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075310 ! regulation of sporangium development
relationship: negatively_regulates GO:0043582 ! sporangium development

[Term]
id: GO:0075313
name: basidium development
namespace: biological_process
def: "The process that leads to the development of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators]
is_a: GO:0075259 ! spore-bearing organ development

[Term]
id: GO:0075314
name: regulation of basidium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of basidium development, a process that leads to the formation of a basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators]
is_a: GO:0075260 ! regulation of spore-bearing organ development
relationship: regulates GO:0075313 ! basidium development

[Term]
id: GO:0075315
name: positive regulation of basidium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075314 ! regulation of basidium development
relationship: positively_regulates GO:0075313 ! basidium development

[Term]
id: GO:0075316
name: negative regulation of basidium development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075314 ! regulation of basidium development
relationship: negatively_regulates GO:0075313 ! basidium development

[Term]
id: GO:0075317
name: ascus development
namespace: biological_process
def: "The process that leads to the development of ascus, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators]
is_a: GO:0048608 ! reproductive structure development

[Term]
id: GO:0075318
name: regulation of ascus development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of ascus development, a process that leads to the formation of basidium, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators]
is_a: GO:0050793 ! regulation of developmental process
relationship: regulates GO:0075317 ! ascus development

[Term]
id: GO:0075319
name: positive regulation of ascus development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators]
is_a: GO:0075261 ! positive regulation of spore-bearing organ development
is_a: GO:0075318 ! regulation of ascus development
relationship: positively_regulates GO:0075317 ! ascus development

[Term]
id: GO:0075320
name: negative regulation of ascus development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators]
is_a: GO:0075262 ! negative regulation of spore-bearing organ development
is_a: GO:0075318 ! regulation of ascus development
relationship: negatively_regulates GO:0075317 ! ascus development

[Term]
id: GO:0075321
name: oomycete sporangium development
namespace: biological_process
def: "The process that leads to the development of an oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiates, through specialized cleavage vesicles, into between 10 and 30 zoospores, which are laterally flagellated." [GOC:pamgo_curators]
is_a: GO:0030436 ! asexual sporulation
is_a: GO:0043582 ! sporangium development

[Term]
id: GO:0075322
name: regulation of oomycete sporangium development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators]
is_a: GO:0034305 ! regulation of asexual sporulation
is_a: GO:0075310 ! regulation of sporangium development
relationship: regulates GO:0075321 ! oomycete sporangium development

[Term]
id: GO:0075323
name: positive regulation of oomycete sporangium development
namespace: biological_process
def: "Any process that activates, maintains or increases the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators]
is_a: GO:0043938 ! positive regulation of sporulation
is_a: GO:0075311 ! positive regulation of sporangium development
is_a: GO:0075322 ! regulation of oomycete sporangium development
relationship: positively_regulates GO:0075321 ! oomycete sporangium development

[Term]
id: GO:0075324
name: negative regulation of oomycete sporangium development
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators]
is_a: GO:0043939 ! negative regulation of sporulation
is_a: GO:0075312 ! negative regulation of sporangium development
is_a: GO:0075322 ! regulation of oomycete sporangium development
relationship: negatively_regulates GO:0075321 ! oomycete sporangium development

[Term]
id: GO:0075325
name: spore dispersal on or near host
namespace: biological_process
def: "Any process by which a symbiont disseminates its spores, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "spore dispersal on or near host during symbiotic interaction" EXACT []
is_a: GO:0051701 ! interaction with host

[Term]
id: GO:0075326
name: active spore dispersal on or near host
namespace: biological_process
def: "Any active process by which a symbiont disseminates its spores, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "active spore dispersal on or near host during symbiotic interaction" EXACT []
is_a: GO:0075325 ! spore dispersal on or near host

[Term]
id: GO:0075327
name: passive spore dispersal on or near host
namespace: biological_process
def: "Any passive process by which a symbiont disseminates its spores, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
synonym: "passive spore dispersal on or near host during symbiotic interaction" EXACT []
is_a: GO:0075325 ! spore dispersal on or near host

[Term]
id: GO:0075328
name: formation by symbiont of arbuscule for nutrient acquisition from host
namespace: biological_process
def: "The assembly by an organism of an arbuscule, a fine, tree-like hyphal structure projected into the host cell for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host

[Term]
id: GO:0075329
name: regulation of arbuscule formation for nutrient acquisition from host
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0044145 ! modulation of development of symbiont during interaction with host
is_a: GO:0060259 ! regulation of feeding behavior
relationship: regulates GO:0075328 ! formation by symbiont of arbuscule for nutrient acquisition from host

[Term]
id: GO:0075330
name: positive regulation of arbuscule formation for nutrient acquisition from host
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044149 ! positive regulation of development of symbiont during interaction with host
is_a: GO:0075329 ! regulation of arbuscule formation for nutrient acquisition from host
relationship: positively_regulates GO:0075328 ! formation by symbiont of arbuscule for nutrient acquisition from host

[Term]
id: GO:0075331
name: negative regulation of arbuscule formation for nutrient acquisition from host
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process.
is_a: GO:0044147 ! negative regulation of development of symbiont during interaction with host
is_a: GO:0075329 ! regulation of arbuscule formation for nutrient acquisition from host
relationship: negatively_regulates GO:0075328 ! formation by symbiont of arbuscule for nutrient acquisition from host

[Term]
id: GO:0075332
name: modulation by host of symbiont adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "modulation by symbiont of host adenylate cyclase-mediated signal transduction; GO:0075335".
is_a: GO:0052470 ! modulation by host of symbiont signal transduction pathway

[Term]
id: GO:0075333
name: positive regulation by host of symbiont adenylate cyclase-mediated signal transduction
namespace: biological_process
def: "Any process by which the host organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the host. To annotate symbiont gene products, consider the biological process term "positive regulation by symbiont of host adenylate cyclase-mediated signal transduction; GO:0075336".
is_a: GO:0052525 ! positive regulation by host of symbiont signal transduction pathway
is_a: GO:0075332 ! modulation by host of symbiont adenylate cyclase-mediated signal transduction

[Term]
id: GO:0075334
name: modulation of symbiont adenylate cyclase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism modulates the frequency, rate or extent of its adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075147 ! regulation of signal transduction in response to host

[Term]
id: GO:0075335
name: positive regulation of symbiont adenylate cyclase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism activates, maintains or increases the frequency, rate or extent of its adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075148 ! positive regulation of signal transduction in response to host
is_a: GO:0075334 ! modulation of symbiont adenylate cyclase-mediated signal transduction in response to host

[Term]
id: GO:0075336
name: negative regulation of symbiont adenylate cyclase-mediated signal transduction in response to host
namespace: biological_process
def: "Any process by which the symbiont organism stops, prevents or reduces the frequency, rate or extent of its symbiont adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is used to annotate gene products of the symbiont.
is_a: GO:0075149 ! negative regulation of signal transduction in response to host
is_a: GO:0075334 ! modulation of symbiont adenylate cyclase-mediated signal transduction in response to host

[Term]
id: GO:0075337
name: positive regulation of growth or development of symbiont on or near host surface
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the symbiont's increase in size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'positive regulation of development of symbiont on or near host surface ; GO:0044143' and 'positive regulation of growth of symbiont on or near host surface ; GO:0044142'.
is_obsolete: true
replaced_by: GO:0044142
replaced_by: GO:0044143

[Term]
id: GO:0075338
name: modulation of growth or development of symbiont during interaction with host
namespace: biological_process
def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'modulation of development of symbiont during interaction with host ; GO:0044145' and 'modulation of growth of symbiont during interaction with host ; GO:0044144'.
is_obsolete: true
replaced_by: GO:0044144
replaced_by: GO:0044145

[Term]
id: GO:0075339
name: positive regulation of growth or development of symbiont during interaction with host
namespace: biological_process
def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'positive regulation of development of symbiont during interaction with host ; GO:0044149' and 'positive regulation of growth of symbiont during interaction with host ; GO:0044148'.
is_obsolete: true

[Term]
id: GO:0075340
name: negative regulation of growth or development of symbiont during interaction with host
namespace: biological_process
def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl]
comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'negative regulation of development of symbiont during interaction with host ; GO:0044147' and 'negative regulation of growth of symbiont during interaction with host ; GO:0044146'.
is_obsolete: true
replaced_by: GO:0044146
replaced_by: GO:0044147

[Term]
id: GO:0075341
name: host cell PML body
namespace: cellular_component
def: "A nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia) located within a cell of a host organism." [GOC:BHF, GOC:jl]
synonym: "host cell PML NB" EXACT []
synonym: "host cell PML nuclear body" EXACT []
is_a: GO:0044094 ! host cell nuclear part

[Term]
id: GO:0075342
name: disassembly by symbiont of host cell PML body
namespace: biological_process
def: "The breakdown, by the symbiont, of a PML body within a host cell. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:BHF, GOC:jl]
synonym: "catabolism by symbiont of host cell PML body" EXACT []
synonym: "degradation by symbiont of host cell PML body" EXACT []
synonym: "disassembly by symbiont of host cell PML body during symbiotic interaction" EXACT []
synonym: "disassembly by symbiont of host cell PML NB" EXACT []
synonym: "disassembly by symbiont of host cell PML nuclear body" EXACT []
synonym: "disruption by symbiont of host cell PML body" EXACT []
is_a: GO:0052008 ! disassembly by symbiont of host cellular component

[Term]
id: GO:0075343
name: modulation by symbiont of abscisic acid levels in host
namespace: biological_process
def: "The alteration by an organism of the levels of abscisic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that regulate abscisic acid levels in the host, consider annotating to 'regulation of abscisic acid mediated signaling ; GO:0009787' or 'regulation of abscisic acid biosynthetic process ; GO:0010115'.
is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels

[Term]
id: GO:0075344
name: modulation by symbiont of host protein levels
namespace: biological_process
def: "The alteration by an organism of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is intended for use in annotation of symbiont gene products.
is_a: GO:0051817 ! modification of morphology or physiology of other organism during symbiotic interaction

[Term]
id: GO:0075345
name: modification by symbiont of host protein
namespace: biological_process
def: "The covalent alteration by an organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that modify host proteins, consider annotation to 'protein modification process' GO:0006464.
subset: gosubset_prok
is_a: GO:0052228 ! metabolism by symbiont of host protein

[Term]
id: GO:0075346
name: modification by symbiont of host protein by ubiquitination
namespace: biological_process
def: "The process by which an organism adds one or more ubiquitin moieties to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that ubiquitinate host proteins, consider annotation to 'protein ubiquitination ; GO:0016567'.
synonym: "modification by symbiont of host protein by ubiquitinylation" EXACT []
synonym: "modification by symbiont of host protein by ubiquitylation " EXACT []
is_a: GO:0075345 ! modification by symbiont of host protein

[Term]
id: GO:0080001
name: mucilage extrusion from seed coat
namespace: biological_process
def: "The process by which seed mucilage expands through hydration and breaks the outer cell wall that encapsulates the whole seed upon imbibition. Mucilage, mainly composed of pectins, is formed during seed development and deposited into the apoplast underneath the outer wall of the seed coat." [PMID:18266922]
synonym: "mucilage release from seed coat" RELATED []
synonym: "secretion of mucilage from seed coat" RELATED []
is_a: GO:0048609 ! reproductive process in a multicellular organism
relationship: part_of GO:0009845 ! seed germination
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0080002
name: UDP-glucose:4-aminobenzoate acylglucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-aminobenzoate + UDP-glucose = p-aminobenzoate-beta-D-glucopyranosyl ester + UDP." [EC:2.4.1.-, PMID:18385129]
synonym: "UDP-glucose:p-aminobenzoate acylglucosyltransferase activity" RELATED []
synonym: "UDP-glucose:p-aminobenzoate glucosyltransferase activity" RELATED []
synonym: "UDP-glucose:pABA acylglucosyltransferase activity" RELATED []
xref: MetaCyc:RXN-6142
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080003
name: thalianol metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving the triterpene thalianol." [PMID:18356490]
synonym: "thalianol metabolism" EXACT [GOC:tair_curators]
is_a: GO:0010683 ! tricyclic triterpenoid metabolic process

[Term]
id: GO:0080004
name: thalian-diol desaturase activity
namespace: molecular_function
def: "Catalysis of the introduction of a double bond to a thalian-diol molecule at carbon 15." [PMID:18356490]
is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors

[Term]
id: GO:0080005
name: photosystem stoichiometry adjustment
namespace: biological_process
def: "Adjustment of Photosystem I/Photosystem II ratio in response to light conditions. The function of photosystem stoichiometry adjustment is to compensate for any deficiency in energy conversion at either photosystem I or photosystem II by increasing the quantity the photosystem that will otherwise become the rate-limiting to overall photosynthesis." [PMID:11607105]
is_a: GO:0010109 ! regulation of photosynthesis

[Term]
id: GO:0080006
name: internode patterning
namespace: biological_process
def: "Determines the spacing between two shoot nodes. A shoot node is the region of the shoot where the spikelet, flower, floret, branch, bud and/or leaves are attached." [GOC:tb]
is_a: GO:0007389 ! pattern specification process
relationship: part_of GO:0048367 ! shoot development

[Term]
id: GO:0080007
name: S-nitrosoglutathione reductase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-nitrosoglutathione (GSNO) + NADH = GSNHOH + NAD, GSNHOH can be further metabolized to ammonia (NH3) and glutathione disulphide (GSSG)." [PMID:11260719]
is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor

[Term]
id: GO:0080008
name: CUL4 RING ubiquitin ligase complex
namespace: cellular_component
def: "A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200]
is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex

[Term]
id: GO:0080009
name: mRNA methylation
namespace: biological_process
def: "The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803]
is_a: GO:0001510 ! RNA methylation
is_a: GO:0016556 ! mRNA modification

[Term]
id: GO:0080010
name: regulation of oxygen and reactive oxygen species metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [PMID:18450450]
is_a: GO:0031323 ! regulation of cellular metabolic process
relationship: regulates GO:0006800 ! oxygen and reactive oxygen species metabolic process

[Term]
id: GO:0080011
name: baruol synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = baruol (D:B-Friedo-Baccharan-5,21-dien-3-ol)." [PMID:17705488]
is_a: GO:0031559 ! oxidosqualene cyclase activity

[Term]
id: GO:0080012
name: N1,N5,N10-tris-(5-hydroxyferuloyl)spermidine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: N1,N5,N10-tris-(5-hydroxyferuloyl)spermidine + S-adenosylmethionine = N',N''-bis(5-hydroxyferuloyl)-N'''-sinapoylspermidine." [PMID:18557837]
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0080013
name: (E,E)-geranyllinalool synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: (E,E,E)-geranylgeranyl diphosphate + H2O = (E,E)-geranyllinalool + diphosphate." [PMID:18398052]
xref: MetaCyc:RXN-10441
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0080014
name: thalianol hydroxylase activity
namespace: molecular_function
def: "Catalysis of the addition of a hydroxyl group to thalianol ((13R,14R,17E)-podioda-8,17,21-trien-3beta-ol) to create thalian-diol ((13R,14R,17E)-podioda-8,17,21-trien-3beta,?-diol). Several thalian-diol isomers may be created by the same enzyme because the hydroxyl group may be attached at one of several different available carbons in ring B or C of thalianol (as indicated by the ''?'')." [PMID:17474751, PMID:18356490]
comment: In Field and Osbourn 2008 (PMID: 18356490), thalianol is referred to as (3S,13S, 3R)-malabarica-8,17,21-trien-3-ol and thalian-diol is referred to as (3S, 13S, 14R)-malabarica-8,17,21-trien-3,?-diol, but the error in this naming system was pointed out in Kolesnikova 2007 (PMID: 17474751). The new names used in the definition have been approved by the authors (Field and Osbourn 2008).
is_a: GO:0004497 ! monooxygenase activity

[Term]
id: GO:0080015
name: sabinene synthase activity
namespace: molecular_function
def: "Catalysis of the conversion of geranyl diphosphate (GPP) into the cyclic monoterpene sabinene." [MetaCyc:RXN-5103, PMID:12566586, PMID:9747540]
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0080016
name: (-)-E-beta-caryophyllene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: farnesyl diphosphate = (-)-E-beta-caryophyllene + diphosphate." [MetaCyc:RXN-8414, PMID:12566586, PMID:9442047]
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0080017
name: alpha-humulene synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: farnesyl diphosphate = alpha-humulene + diphosphate." [PMID:12566586, PMID:9442047]
is_a: GO:0009975 ! cyclase activity
is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates

[Term]
id: GO:0080018
name: anthocyanin 5-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction:anthocyanin + UDP-D-glucose = anthocyanin-5-O-glucoside + UDP." [PMID:15807784]
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080019
name: fatty acyl-CoA reductase (alcohol-forming) activity
namespace: molecular_function
def: "Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH = a very long chain primary alcohol + NADP + CoA." [PMID:16980563]
is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

[Term]
id: GO:0080020
name: regulation of coenzyme A biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzyme A." [PMID:18621975]
is_a: GO:0006140 ! regulation of nucleotide metabolic process
is_a: GO:0009118 ! regulation of nucleoside metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0051196 ! regulation of coenzyme metabolic process
relationship: regulates GO:0015937 ! coenzyme A biosynthetic process

[Term]
id: GO:0080021
name: response to benzoic acid stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [PMID:18753285]
is_a: GO:0010033 ! response to organic substance

[Term]
id: GO:0080022
name: primary root development
namespace: biological_process
def: "The process whose specific outcome is the progression of the primary root over time, from its formation to the mature structure. The primary root develops directly from the embryonic radicle." [GOC:dhl]
is_a: GO:0048364 ! root development

[Term]
id: GO:0080023
name: 3R-hydroxyacyl-CoA dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3R-hydroxyacyl-CoA = 2E-enoyl-CoA + H2O." [PMID:16982622]
is_a: GO:0016836 ! hydro-lyase activity

[Term]
id: GO:0080024
name: indolebutyric acid metabolic process
namespace: biological_process
def: "The chemical reactions and pathways involving indolebutyric acid, a compound that serves as an active or storage form of the hormone indole-3-acetic acid (an auxin) in many plants." [PMID:18725356]
synonym: "IBA metabolic process" EXACT []
synonym: "IBA metabolism" EXACT []
synonym: "indole-3-butyric acid metabolic process" NARROW []
is_a: GO:0009850 ! auxin metabolic process

[Term]
id: GO:0080025
name: phosphatidylinositol-3,5-bisphosphate binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a diphosphorylated derivative of phosphatidylinositol." [PMID:18397324]
synonym: "PtdIns(3,5)P2 binding" EXACT []
is_a: GO:0035091 ! phosphoinositide binding

[Term]
id: GO:0080026
name: response to indolebutyric acid stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus." [PMID:18725356]
synonym: "response to IBA stimulus" EXACT []
synonym: "response to indole-3-butyric acid stimulus" NARROW []
is_a: GO:0009733 ! response to auxin stimulus

[Term]
id: GO:0080027
name: response to herbivore
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a herbivore." [PMID:18987211]
is_a: GO:0051707 ! response to other organism

[Term]
id: GO:0080028
name: nitrile biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom." [PMID:18987211]
is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process
is_a: GO:0050898 ! nitrile metabolic process

[Term]
id: GO:0080029
name: cellular response to boron levels
namespace: biological_process
def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of boron." [PMID:18952773]
is_a: GO:0010036 ! response to boron
is_a: GO:0031669 ! cellular response to nutrient levels
is_a: GO:0070887 ! cellular response to chemical stimulus

[Term]
id: GO:0080030
name: methyl indole-3-acetate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction methyl indole-3-acetate (MeIAA) + H2O = indole-3-acetate (IAA)+ methanol." [PMID:18467465]
synonym: "indole-3-Acetic acid methyl ester esterase activity" EXACT []
synonym: "MeIAA esterase activity" EXACT []
synonym: "Methyl IAA esterase activity" EXACT []
synonym: "methyl indole-3-acetate esterase activity" RELATED []
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0080031
name: methyl salicylate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction methyl salicylate (MeSA) + H2O = salicylic acid (SA)+ methanol." [PMID:18467465, PMID:18643994]
synonym: "MESA esterase activity" EXACT []
synonym: "methyl SA esterase activity" EXACT []
synonym: "methylsalicylate esterase activity" EXACT []
synonym: "salicylic acid methyl ester esterase activity" EXACT []
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0080032
name: methyl jasmonate esterase activity
namespace: molecular_function
def: "Catalysis of the reaction methyl jasmonate (MeJA) + H2O = jasmonate (JA)+ methanol." [PMID:15233793, PMID:18467465]
synonym: "jasmonic acid methyl ester esterase activity" EXACT []
synonym: "MEJA esterase activity" EXACT []
synonym: "methyl JA esterase activity" EXACT []
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0080033
name: response to nitrite
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:dhl, PMID:17951451]
is_a: GO:0010035 ! response to inorganic substance

[Term]
id: GO:0080034
name: host response to induction by symbiont of tumor, nodule or growth in host
namespace: biological_process
def: "A change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the formation of an abnormal mass of cells in the host organism, induced by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:18836040]
is_a: GO:0009608 ! response to symbiont

[Term]
id: GO:0080035
name: 2-hydroxy-but-3-enyl glucosinolate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of progoitrin, a 2-hydroxy-but-3-enyl glucosinolate. Glucosinolates are substituted thioglucosides found in rapeseed products and related cruciferae, and progoitrin has been implicated in causing goiters in mammals and bitter taste in cruciferous vegetables." [PMID:11560911, PMID:18945935]
synonym: "2-hydroxy-but-3-enyl glucosinolate anabolism" EXACT []
synonym: "2-hydroxy-but-3-enyl glucosinolate biosynthesis" EXACT []
synonym: "2-hydroxy-but-3-enyl glucosinolate formation" EXACT []
synonym: "2-hydroxy-but-3-enyl glucosinolate synthesis" RELATED []
synonym: "progoitrin biosynthesis" EXACT []
synonym: "progoitrin biosynthetic process" RELATED []
synonym: "progoitrin synthesis" EXACT []
is_a: GO:0019761 ! glucosinolate biosynthetic process

[Term]
id: GO:0080036
name: regulation of cytokinin mediated signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by cytokinin." [GOC:dhl]
synonym: "regulation of cytokinin mediated signalling" EXACT [GOC:mah]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0009736 ! cytokinin mediated signaling pathway

[Term]
id: GO:0080037
name: negative regulation of cytokinin mediated signaling pathway
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by cytokinin." [GOC:dhl, PMID:14973166]
synonym: "negative regulation of cytokinin mediated signalling" EXACT [GOC:mah]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0080036 ! regulation of cytokinin mediated signaling pathway
relationship: negatively_regulates GO:0009736 ! cytokinin mediated signaling pathway

[Term]
id: GO:0080038
name: positive regulation of cytokinin mediated signaling pathway
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by cytokinin." [GOC:dhl]
synonym: "positive regulation of cytokinin mediated signalling" EXACT [GOC:mah]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0080036 ! regulation of cytokinin mediated signaling pathway
relationship: positively_regulates GO:0009736 ! cytokinin mediated signaling pathway

[Term]
id: GO:0080039
name: xyloglucan endotransglucosylase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of a beta-(1,4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of a xyloglucan or an oligosaccharide of xyloglucan." [EC:2.4.1.207, GOC:ASK, PMID:1400418, PMID:1554366]
is_a: GO:0046527 ! glucosyltransferase activity

[Term]
id: GO:0080040
name: positive regulation of cellular response to phosphate starvation
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of cellular response to phosphate starvation." [PMID:18315545]
is_a: GO:0010647 ! positive regulation of cell communication
is_a: GO:0032109 ! positive regulation of response to nutrient levels
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: positively_regulates GO:0016036 ! cellular response to phosphate starvation

[Term]
id: GO:0080041
name: ADP-ribose pyrophosphohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-ribose + H2O = AMP + ribose-1-phosphate." [GOC:tb]
is_a: GO:0019144 ! ADP-sugar diphosphatase activity

[Term]
id: GO:0080042
name: ADP-glucose pyrophosphohydrolase activity
namespace: molecular_function
def: "Catalysis of the reaction: ADP-glucose + H2O = AMP + glucose-1-phosphate." [GOC:tb]
is_a: GO:0019144 ! ADP-sugar diphosphatase activity

[Term]
id: GO:0080043
name: quercetin 3-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3-hydroxy group of a quercetin molecule." [PMID:15352060]
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080044
name: quercetin 7-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 7-hydroxy group of a quercetin molecule." [PMID:15352060]
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080045
name: quercetin 3'-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3'-hydroxy group of a quercetin molecule." [PMID:15352060]
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080046
name: quercetin 4'-O-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 4'-hydroxy group of a quercetin molecule." [PMID:15352060]
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080047
name: GDP-L-galactose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-L-galactose + Pi = L-galactose-1-P +GDP." [PMID:18463094]
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0080048
name: GDP-D-glucose phosphorylase activity
namespace: molecular_function
def: "Catalysis of the reaction: GDP-D-glucose + Pi = D-glucose-1-P + GDP." [PMID:18463094]
is_a: GO:0004645 ! phosphorylase activity

[Term]
id: GO:0080049
name: L-gulono-1,4-lactone dehydrogenase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-gulono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." [PMID:18190525]
is_a: GO:0016632 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor

[Term]
id: GO:0080050
name: regulation of seed development
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of seed development." [PMID:19141706]
is_a: GO:0048580 ! regulation of post-embryonic development
relationship: regulates GO:0048316 ! seed development

[Term]
id: GO:0080051
name: cutin transport
namespace: biological_process
def: "The directed movement of cutin into, out of, within or between cells by means of some external agent such as a transporter or pore. Cutin, which consists of C16-18 fatty acids, is the major component of the cuticle that covers the plant surface." [PMID:17951461]
is_a: GO:0015909 ! long-chain fatty acid transport

[Term]
id: GO:0080052
name: response to histidine
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus." [PMID:15889294]
is_a: GO:0043200 ! response to amino acid stimulus

[Term]
id: GO:0080053
name: response to phenylalanine
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus." [PMID:15889294]
is_a: GO:0043200 ! response to amino acid stimulus

[Term]
id: GO:0080054
name: low affinity nitrate transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of nitrate ions (NO3-) from one side of a membrane to the other. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [PMID:19050168]
is_a: GO:0015112 ! nitrate transmembrane transporter activity

[Term]
id: GO:0080055
name: low affinity nitrate transport
namespace: biological_process
def: "The directed movement of nitrate into, out of, within or between cells by means of some external agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [PMID:19050168]
is_a: GO:0015706 ! nitrate transport

[Term]
id: GO:0080056
name: petal vascular tissue pattern formation
namespace: biological_process
def: "Vascular tissue pattern formation as it occurs in the petal of vascular plants." [PMID:17369435]
is_a: GO:0010051 ! xylem and phloem pattern formation

[Term]
id: GO:0080057
name: sepal vascular tissue pattern formation
namespace: biological_process
def: "Vascular tissue pattern formation as it occurs in the sepal of vascular plants." [PMID:17369435]
is_a: GO:0010051 ! xylem and phloem pattern formation

[Term]
id: GO:0080058
name: protein amino acid deglutathionylation
namespace: biological_process
def: "The protein modification process by which a glutathione molecule is removed from a protein amino acid by breaking a disulfide linkage." [GOC:tb]
is_a: GO:0006464 ! protein modification process

[Term]
id: GO:0080059
name: flavonol 3-O-arabinosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-arabinose + a flavonol = UDP + a flavonol 3-O-D-arabinoside." [PMID:18757557]
is_a: GO:0016763 ! transferase activity, transferring pentosyl groups

[Term]
id: GO:0080060
name: integument development
namespace: biological_process
def: "The process whose specific outcome is the progression of the integument over time, from its formation to the mature structure. Integument is one of the layers of tissue that usually covers the ovule, enveloping the nucellus and forming the micropyle at the apex." [PMID:19054366, PO:0020021]
is_a: GO:0009888 ! tissue development
relationship: part_of GO:0048481 ! ovule development

[Term]
id: GO:0080061
name: indole-3-acetonitrile nitrilase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetonitrile (IAN) + 2H2O = indole-3-acetic acid (IAA) + NH3." [EC:3.5.5.1, MetaCyc:RXN-1404]
is_a: GO:0000257 ! nitrilase activity

[Term]
id: GO:0080062
name: cytokinin 9-beta-glucosyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: UDP-glucose + N6-alkylaminopurine = UDP + N6-alkylaminopurine-9-beta-D-glucoside." [PMID:15342621]
is_a: GO:0035251 ! UDP-glucosyltransferase activity

[Term]
id: GO:0080063
name: 3-hydroxybutyryl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-hydroxybutyryl-[acyl-carrier-protein] = crotonoyl-[acyl-carrier-protein] + H2O." [PMID:19101548]
is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity

[Term]
id: GO:0080064
name: 4,4-dimethyl-9beta,19-cyclopropylsterol-4alpha-methyl oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4,4-dimethyl-9beta,19-cyclopropylsterol + 3NADPH + 3H+ + 3O2 = 4alpha-carboxy, 4beta-methyl-9beta,19-cyclopropylsterol + 3NADP+ + 3H2O. This overall reaction proceeds through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH)." [PMID:14653780]
is_a: GO:0000254 ! C-4 methylsterol oxidase activity

[Term]
id: GO:0080065
name: 4-alpha-methyl-delta7-sterol-4alpha-methyl oxidase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4alpha-methyl-delta7-sterol + 3NADPH + 3H+ + 3O2 = 4alpha-carboxy, delta7-sterol + 3NADP+ + 3H2O. This overall reaction proceeds through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH)." [PMID:14653780]
is_a: GO:0000254 ! C-4 methylsterol oxidase activity

[Term]
id: GO:0080066
name: 3-methylthiopropyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 3-methylthiopropyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 3-methylthiopropyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity

[Term]
id: GO:0080067
name: 4-methylthiobutyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 4-methylthiobutyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 4-methylthiobutyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity

[Term]
id: GO:0080068
name: 5-methylthiopentyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 5-methylthiopentyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 5-methylthiopentyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity

[Term]
id: GO:0080069
name: 7-methylthioheptyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 7-methylthioheptyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 7-methylthioheptyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity

[Term]
id: GO:0080070
name: 8-methylthiooctyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: 8-methylthiooctyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 8-methylthiooctyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity

[Term]
id: GO:0080071
name: indol-3-yl-methyl-desulfoglucosinolate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: indol-3-yl-methyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = indol-3-yl-methyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143]
is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity

[Term]
id: GO:0080072
name: spermidine:sinapoyl CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a sinapoyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165]
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0080073
name: spermidine:coumaroyl CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a coumaroyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165]
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0080074
name: spermidine:caffeoyl CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a caffeoyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165]
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0080075
name: spermidine:feruloyl CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a feruloyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165]
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0080076
name: caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a caffeoyl CoA molecule." [PMID:19077165]
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0080077
name: trihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a trihydroxyferuloyl spermidine molecule." [PMID:19077165]
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0080078
name: tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a tricaffeoyl spermidine molecule." [PMID:19077165]
is_a: GO:0008171 ! O-methyltransferase activity

[Term]
id: GO:0080079
name: cellobiose glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of glucosidic link in cellobiose." [PMID:15604686]
is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds

[Term]
id: GO:0080081
name: 4-methylumbelliferyl-beta-D-glucopyranoside beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of glucosidic link in 4-methylumbelliferyl-beta-D-glucopyranoside." [PMID:15604686]
is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds

[Term]
id: GO:0080082
name: esculin beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of glucosidic link in esculin." [PMID:15604686]
is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds

[Term]
id: GO:0080083
name: beta-gentiobiose beta-glucosidase activity
namespace: molecular_function
def: "Catalysis of the hydrolysis of glucosidic link in beta-gentiobiose." [PMID:15604686]
is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds

[Term]
id: GO:0080084
name: 5S rDNA binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the 5S rDNA sequence encoding ribosomal 5S rRNA, which is individually transcribed by RNA polymerase III, rather than by RNA polymerase I, in species where it exists." [PMID:12711688]
is_a: GO:0000182 ! rDNA binding

[Term]
id: GO:0080085
name: signal recognition particle, chloroplast targeting
namespace: cellular_component
def: "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to the chloroplast." [PMID:17513500]
is_a: GO:0048500 ! signal recognition particle

[Term]
id: GO:0080086
name: stamen filament development
namespace: biological_process
def: "The process whose specific outcome is the progression of the filament over time, from its formation to the mature structure. Filament is the stalk of a stamen." [PMID:19139039, PO:0009067]
synonym: "filament development" EXACT []
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048443 ! stamen development

[Term]
id: GO:0080087
name: callose binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with callose. Callose is a linear 1,3-beta-D-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:dhl]
is_a: GO:0030247 ! polysaccharide binding

[Term]
id: GO:0080088
name: spermidine hydroxycinnamate conjugate biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of spermidine hydroxycinnamate conjugates." [PMID:19077165]
is_a: GO:0006596 ! polyamine biosynthetic process

[Term]
id: GO:0080089
name: sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a sinapoyl group to a nitrogen atom on the spermidine molecule." [PMID:19168716]
is_a: GO:0016410 ! N-acyltransferase activity

[Term]
id: GO:0080090
name: regulation of primary metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694]
is_a: GO:0019222 ! regulation of metabolic process
relationship: regulates GO:0044238 ! primary metabolic process

[Term]
id: GO:0080091
name: regulation of raffinose metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving raffinose." [PMID:19211694]
is_a: GO:0006109 ! regulation of carbohydrate metabolic process
relationship: regulates GO:0033530 ! raffinose metabolic process

[Term]
id: GO:0080092
name: regulation of pollen tube growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of pollen tube growth." [PMID:19208902]
is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation
is_a: GO:0043900 ! regulation of multi-organism process
is_a: GO:0051239 ! regulation of multicellular organismal process
is_a: GO:0051510 ! regulation of unidimensional cell growth
relationship: regulates GO:0009860 ! pollen tube growth

[Term]
id: GO:0080093
name: regulation of photorespiration
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of photorespiration. Photorespiration is a light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved." [GOC:tb]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
relationship: regulates GO:0009853 ! photorespiration

[Term]
id: GO:0080094
name: response to trehalose-6-phosphate stimulus
namespace: biological_process
def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus." [PMID:19193861]
is_a: GO:0034285 ! response to disaccharide stimulus

[Term]
id: GO:0080095
name: phosphatidylethanolamine-sterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphatidylethanolamine + a sterol = a sterol ester + a lysophosphatidylethanolamine." [PMID:16020547]
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0080096
name: phosphatidate-sterol O-acyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a phosphatidate + a sterol = a sterol ester + a lysophosphatidate." [PMID:16020547]
is_a: GO:0008374 ! O-acyltransferase activity

[Term]
id: GO:0080097
name: L-tryptophan:pyruvate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tryptophan + pyruvate = indolepyruvate + L-alanine." [PMID:18394996]
comment: This reaction falls within the larger set of reactions associated with EC 2.6.1.28 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.28; note: 3-indole-2-oxopropanoate = indolepyruvate).
xref: MetaCyc:RXN-10139
is_a: GO:0070529 ! L-tryptophan aminotransferase activity

[Term]
id: GO:0080098
name: L-tyrosine:pyruvate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-tyrosine + pyruvate = 4-hydroxyphenylpyruvate + L-alanine." [PMID:18394996]
comment: This reaction falls within the larger set of reactions associated with EC 2.6.1.28 and several other EC numbers (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.44).
xref: MetaCyc:RXN3O-4157
is_a: GO:0070547 ! L-tyrosine aminotransferase activity

[Term]
id: GO:0080099
name: L-methionine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-methionine + 2-oxoglutarate = 4-methylthio-2-oxobutyrate + L-glutamate." [PMID:18394996]
comment: This reaction falls within the larger set of reactions associated with EC 2.6.1.5 (See BRENDA: http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.5).
synonym: "L-methionine:alpha-ketoglutarate aminotransferase activity" EXACT []
is_a: GO:0010326 ! methionine-oxo-acid transaminase activity

[Term]
id: GO:0080100
name: L-glutamine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-glutamine + 2-oxoglutarate = 2-oxoglutaramate + L-glutamate." [PMID:18394996]
comment: This reaction falls within the larger set of reactions associated with EC 2.6.1.50 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.50).
synonym: "L-glutamine:alpha-ketoglutarate aminotransferase activity" EXACT []
is_a: GO:0008483 ! transaminase activity

[Term]
id: GO:0080101
name: phosphatidyl-N-dimethylethanolamine N-methyltransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine." [EC:2.1.1.71, PMID:19366698]
is_a: GO:0008170 ! N-methyltransferase activity

[Term]
id: GO:0080102
name: 3-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the conversion of 3-methylthiopropyl glucosinolate to 3-methylsulfinylpropyl glucosinolate." [PMID:18799661]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0080103
name: 4-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the conversion of 4-methylthiopropyl glucosinolate to 4-methylsulfinylpropyl glucosinolate." [PMID:18799661]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0080104
name: 5-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the conversion of 5-methylthiopropyl glucosinolate to 5-methylsulfinylpropyl glucosinolate." [PMID:18799661]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0080105
name: 6-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the conversion of 6-methylthiopropyl glucosinolate to 6-methylsulfinylpropyl glucosinolate." [PMID:18799661]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0080106
name: 7-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the conversion of 7-methylthiopropyl glucosinolate to 7-methylsulfinylpropyl glucosinolate." [PMID:18799661]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0080107
name: 8-methylthiopropyl glucosinolate S-oxygenase activity
namespace: molecular_function
def: "Catalysis of the conversion of 8-methylthiopropyl glucosinolate to 8-methylsulfinylpropyl glucosinolate." [PMID:18799661]
is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

[Term]
id: GO:0080108
name: S-alkylthiohydroximate lyase activity
namespace: molecular_function
def: "Catalysis of the conversion of a S-alkylthiohydroximate to a thiohydroximate." [PMID:14871316]
synonym: "S-alkylthiohydroximate C-S lyase activity" NARROW []
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0080109
name: indole-3-acetonitrile nitrile hydratase activity
namespace: molecular_function
def: "Catalysis of the reaction: indole-3-acetonitrile (IAN) + H2O = indole-3-acetamide (IAM)." [EC:4.2.1.84, MetaCyc:RXN-7567, PMID:11607511, PMID:12430025]
is_a: GO:0018822 ! nitrile hydratase activity

[Term]
id: GO:0080110
name: sporopollenin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sporopollenin, a primary constituent of the pollen exine layer." [PMID:19218397]
synonym: "sporopollenin biosynthesis" EXACT []
is_a: GO:0019438 ! aromatic compound biosynthetic process
relationship: part_of GO:0010584 ! pollen exine formation

[Term]
id: GO:0080111
name: DNA demethylation
namespace: biological_process
def: "The removal of a methyl group from C-5 or N-4 of cytosine or N-6 of adenine in a DNA molecule." [PMID:17208187]
is_a: GO:0006304 ! DNA modification
is_a: GO:0040029 ! regulation of gene expression, epigenetic
is_a: GO:0070988 ! demethylation

[Term]
id: GO:0080112
name: seed growth
namespace: biological_process
def: "The increase in size or mass of a seed. Seed is a propagating organ formed in the reproductive cycle of gymnosperms and angiosperms, derived from the ovule and enclosing an embryo." [GOC:dhl, PO:0009010]
is_a: GO:0035265 ! organ growth
relationship: part_of GO:0048316 ! seed development

[Term]
id: GO:0080113
name: regulation of seed growth
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of growth of the seed of an plant." [PMID:19141706]
synonym: "regulation of seed size" EXACT []
is_a: GO:0046620 ! regulation of organ growth
is_a: GO:0080050 ! regulation of seed development
relationship: regulates GO:0080112 ! seed growth

[Term]
id: GO:0080114
name: positive regulation of glycine hydroxymethyltransferase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of glycine hydroxymethyltransferase activity, the catalysis of the reaction 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1, PMID:19223513]
is_a: GO:0051347 ! positive regulation of transferase activity

[Term]
id: GO:0080115
name: myosin XI tail binding
namespace: molecular_function
def: "Interacting selectively and non-covalently with the tail region of a myosin XI heavy chain." [PMID:18703495]
is_a: GO:0032029 ! myosin tail binding

[Term]
id: GO:0080116
name: glucuronoxylan glucuronosyltransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of glucuronate to the xylan backbone of glucuronoxylan molecule." [PMID:18980649]
is_a: GO:0015020 ! glucuronosyltransferase activity

[Term]
id: GO:0080117
name: secondary growth
namespace: biological_process
def: "Increase in plant girth due to the activity of lateral meristems (vascular and cork cambium)." [PMID:19074290]
is_a: GO:0040007 ! growth

[Term]
id: GO:0080118
name: brassinosteroid sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of a brassinosteroid acceptor, producing the sulfated brassinosteroid derivative and 3'-phosphoadenosine 5'-phosphate." [ChEBI:22921, PMID:10409637, PMID:17039368]
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0080119
name: ER body organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the formation of ER (endoplasmic reticulum) body. ER body is a compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:18780803, PMID:19147648]
synonym: "endoplasmic reticulum body organization" EXACT []
synonym: "endoplasmic reticulum body organization and biogenesis" RELATED [GOC:mah]
synonym: "ER body organization and biogenesis" RELATED [GOC:mah]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0080120
name: CAAX-box protein maturation
namespace: biological_process
def: "A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid moieties to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase." [PMID:12039957, PMID:17114793, PMID:18641086]
synonym: "CAAX-box protein processing" RELATED []
synonym: "farnesylated protein maturation" RELATED [GOC:vw]
is_a: GO:0051604 ! protein maturation

[Term]
id: GO:0080121
name: AMP transport
namespace: biological_process
def: "The directed movement of AMP, adenosine monophosphate, into, out of, within or between cells by means of some external agent such as a transporter or pore." [PMID:18923018]
synonym: "adenosine monophosphate transport" EXACT []
is_a: GO:0051503 ! adenine nucleotide transport

[Term]
id: GO:0080122
name: AMP transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other." [PMID:18923018]
synonym: "adenosine monophosphate transmembrane transporter activity" EXACT []
is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity

[Term]
id: GO:0080123
name: jasmonate-amino synthetase activity
namespace: molecular_function
def: "Catalysis of the reaction: jasmonate (JA) + an amino acid (including non-standard amino acids, such as ACC (1-aminocyclopropane-1-carboxylate)) = a jasmonyl-amino acid (amide-linked) conjugate." [PMID:15258265, PMID:17291501]
synonym: "ja-amino synthetase activity" EXACT []
synonym: "jasmonate-amido synthetase activity" EXACT []
synonym: "jasmonate-amino acid conjugate synthetase activity" EXACT []
synonym: "jasmonate-amino acid synthetase activity" EXACT []
synonym: "jasmonate:amino acid synthetase activity" EXACT []
synonym: "jasmonic acid-amino synthetase activity" EXACT []
synonym: "jasmonyl-amino synthetase activity" EXACT []
is_a: GO:0016881 ! acid-amino acid ligase activity

[Term]
id: GO:0080124
name: pheophytinase activity
namespace: molecular_function
def: "Catalysis of the reaction: pheophytin + H2O = phytol + pheophorbide." [PMID:19304936]
synonym: "pheophytin pheophorbide hydrolase activity" EXACT []
is_a: GO:0004091 ! carboxylesterase activity

[Term]
id: GO:0080125
name: multicellular structure septum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the multicellular structure septum over time, from its formation to the mature structure. The multicellular structure septum is the thin partition or membrane that divides a cavity or a mass of tissue." [GOC:dhl]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0080126
name: ovary septum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the ovary septum over time, from its formation to the mature structure. The ovary septum is the thin partition that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)." [PMID:17855426]
is_a: GO:0080125 ! multicellular structure septum development
relationship: part_of GO:0048440 ! carpel development

[Term]
id: GO:0080127
name: fruit septum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the fruit septum over time, from its formation to the mature structure. The fruit septum is a thin partition or membrane that divides a cavity or a mass of tissue in the fruit." [GOC:dhl, PO:0005008]
is_a: GO:0003006 ! reproductive developmental process
is_a: GO:0009791 ! post-embryonic development
is_a: GO:0080125 ! multicellular structure septum development
relationship: part_of GO:0010154 ! fruit development

[Term]
id: GO:0080128
name: anther septum development
namespace: biological_process
def: "The process whose specific outcome is the progression of the anther septum over time, from its formation to the mature structure. The anther septum is a thin partition or stretch of cells that are present in the anther dehiscence zone." [GOC:dhl, PO:0005010]
is_a: GO:0080125 ! multicellular structure septum development
relationship: part_of GO:0048653 ! anther development

[Term]
id: GO:0080129
name: proteasome core complex assembly
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles." [PMID:12401807, PMID:17971041]
synonym: "20S proteasome assembly" EXACT []
is_a: GO:0043248 ! proteasome assembly

[Term]
id: GO:0080130
name: L-phenylalanine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate." [GOC:pmn_curators, PMID:18394996]
comment: This reaction falls within the larger set of reactions associated with EC 2.6.1.57 and several other EC numbers (See BRENDA:http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.57).
synonym: "L-phenylalanine:alpha-ketoglutarate aminotransferase activity" EXACT []
xref: MetaCyc:PHEAMINOTRANS-RXN
is_a: GO:0070546 ! L-phenylalanine aminotransferase activity

[Term]
id: GO:0080131
name: hydroxyjasmonate sulfotransferase activity
namespace: molecular_function
def: "Catalysis of the reaction: a hydroxyjasmonate + PAPS (phosphoadenosine-5'-phosphosulfate) = a hydroxyjasmonate sulfate + PAP (adenosine-3',5'-bisphosphate)." [EC:2.8.2.-, GOC:pmn_curators, MetaCyc:RXN-10451, MetaCyc:RXN-10453, PMID:12637544]
synonym: "12-hydroxyjasmonate sulfotransferase activity" NARROW []
synonym: "12-hydroxyjasmonic acid sulfotransferase activity" NARROW []
synonym: "12-OHJA sulfotransferase activity" NARROW []
synonym: "hydroxyjasmonic acid sulfotransferase activity" EXACT []
synonym: "OHJA sulfotransferase activity" EXACT []
is_a: GO:0008146 ! sulfotransferase activity

[Term]
id: GO:0080132
name: fatty acid alpha-hydroxylase activity
namespace: molecular_function
def: "Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain." [PMID:19054355]
synonym: "fatty acid 2-hydroxylase" EXACT []
is_a: GO:0016491 ! oxidoreductase activity

[Term]
id: GO:0080133
name: midchain alkane hydroxylase activity
namespace: molecular_function
def: "Catalysis of the conversion of an alkane to a secondary alcohol." [PMID:17905869]
is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

[Term]
id: GO:0080134
name: regulation of response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0006950 ! response to stress

[Term]
id: GO:0080135
name: regulation of cellular response to stress
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0080134 ! regulation of response to stress
relationship: regulates GO:0033554 ! cellular response to stress

[Term]
id: GO:0080136
name: priming of cellular response to stress
namespace: biological_process
def: "The process that enables cells to respond in a more rapid and robust manner than nonprimed cells to much lower levels of a stimulus indicating the organism is under stress." [PMID:19318610]
synonym: "priming of response to stress" BROAD []
synonym: "priming of stress response" BROAD []
is_a: GO:0080135 ! regulation of cellular response to stress
relationship: part_of GO:0033554 ! cellular response to stress

[Term]
id: GO:0080137
name: DNA-directed RNA polymerase V complex
namespace: cellular_component
def: "RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants. In addition to RNA polymerases I, II, and III, the essential RNA polymerases present in all eukaryotes, plants have two additional nuclear RNA polymerases, Pol IV and Pol V, that play nonredundant roles in siRNA-directed DNA methylation and gene silencing. Pol IV is required for siRNA production and Pol V is required for generating noncoding transcripts at target loci. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol V are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases." [PMID:19110459]
is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex

[Term]
id: GO:0080138
name: boron uptake transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of boron from the outside of a cell to the inside of the cell across a membrane." [PMID:18603465]
is_a: GO:0015563 ! uptake transmembrane transporter activity

[Term]
id: GO:0080139
name: boron efflux transmembrane transporter activity
namespace: molecular_function
def: "Catalysis of the transfer of boron from the inside of the cell to the outside of the cell across a membrane." [PMID:18603465]
is_a: GO:0015562 ! efflux transmembrane transporter activity
is_a: GO:0046715 ! boron transmembrane transporter activity

[Term]
id: GO:0080140
name: regulation of jasmonic acid metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving jasmonic acid." [GOC:dhl]
is_a: GO:0019217 ! regulation of fatty acid metabolic process
relationship: regulates GO:0009694 ! jasmonic acid metabolic process

[Term]
id: GO:0080141
name: regulation of jasmonic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of jasmonic acid." [GOC:dhl]
is_a: GO:0042304 ! regulation of fatty acid biosynthetic process
is_a: GO:0080140 ! regulation of jasmonic acid metabolic process
relationship: regulates GO:0009695 ! jasmonic acid biosynthetic process

[Term]
id: GO:0080142
name: regulation of salicylic acid biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of salicylic acid." [GOC:dhl]
is_a: GO:0010337 ! regulation of salicylic acid metabolic process
is_a: GO:0031326 ! regulation of cellular biosynthetic process
relationship: regulates GO:0009697 ! salicylic acid biosynthetic process

[Term]
id: GO:0080143
name: regulation of amino acid export
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of amino acid export. Amino acid export is the directed movement of amino acids out of a cell or organelle." [PMID:20018597]
is_a: GO:0051955 ! regulation of amino acid transport
relationship: regulates GO:0032973 ! amino acid export

[Term]
id: GO:0080144
name: amino acid homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of amino acid within an organism or cell." [PMID:19955263]
is_a: GO:0048878 ! chemical homeostasis

[Term]
id: GO:0080145
name: cysteine homeostasis
namespace: biological_process
def: "Any process involved in the maintenance of an internal equilibrium of cysteine within an organism or cell." [PMID:19955263]
is_a: GO:0080144 ! amino acid homeostasis

[Term]
id: GO:0080146
name: L-Cysteine desulfhydrase activity
namespace: molecular_function
def: "Catalysis of the reaction: L-cysteine + H2O = sulfide + NH3 + pyruvate." [PMID:19955263]
is_a: GO:0016846 ! carbon-sulfur lyase activity

[Term]
id: GO:0085001
name: formation by symbiont of stylet for nutrient acquisition from host
namespace: biological_process
def: "The assembly by a symbiont of a stylet, a hollow protrusible spear-like structure projected into the host cell for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition from host

[Term]
id: GO:0085002
name: interaction with host mediated by secreted substance released by symbiont from symbiotic structure
namespace: biological_process
def: "An interaction with the host organism mediated by a symbiont secreted substance released by specialized structures generated in either organisms as a result of the symbiotic interaction. The term host is used for the larger (macro) of the two members of a symbiosis." [GOC:pamgo_curators]
comment: This term can be used for annotation of structures like the parasitophorous vacuole which are symbiont induced but entirely host-derived, as well as structures like the stylet which are entirely symbiont-derived.
is_a: GO:0052048 ! interaction with host via secreted substance during symbiotic interaction

[Term]
id: GO:0085003
name: interaction with host via secreted substance released from stylet
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the stylet, a hollow protrusible spear-like structure in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure

[Term]
id: GO:0085004
name: interaction with host via secreted substance released from haustorium
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the haustorium, a projection from a cell or tissue that penetrates the host's cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure

[Term]
id: GO:0085005
name: interaction with host via secreted substance released from invasive hyphae
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via invasive hyphae. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure

[Term]
id: GO:0085006
name: interaction with host mediated by symbiont secreted substance released from parasitophorous vacuole
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the parasitophorous vacuole, a specialized sac within the host in which the parasite resides. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure

[Term]
id: GO:0085007
name: interaction with host via secreted substance released from rhoptry
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the rhoptry, a large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure

[Term]
id: GO:0085008
name: interaction with host via secreted substance released from microneme
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the microneme, a small, elongated secretory organelle that forms part of the apical complex of an apicomplexan parasite. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure

[Term]
id: GO:0085009
name: interaction with host mediated by symbiont secreted substance released from Maurer's cleft
namespace: biological_process
def: "An interaction with the host organism mediated by a substance released by the other (symbiont) organism via Maurer's cleft. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "interaction with host mediated by symbiont secreted substance released from Maurers cleft" EXACT []
is_a: GO:0085002 ! interaction with host mediated by secreted substance released by symbiont from symbiotic structure

[Term]
id: GO:0085010
name: interaction with host mediated by secreted substance entering host via endocytosis
namespace: biological_process
def: "An interaction with the host organism mediated by a secreted substance from the symbiont entering host cells via endocytosis of the substance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0052048 ! interaction with host via secreted substance during symbiotic interaction

[Term]
id: GO:0085011
name: interaction with host via protein secreted by Sec complex
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the symbiont organism by a Sec complex. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "interaction with host via protein secreted by Sec secretion system" EXACT []
is_a: GO:0052048 ! interaction with host via secreted substance during symbiotic interaction

[Term]
id: GO:0085012
name: interaction with host via protein secreted by Tat complex
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the symbiont organism by a Tat complex. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
synonym: "interaction with host via protein secreted by Tat secretion system" EXACT []
is_a: GO:0052048 ! interaction with host via secreted substance during symbiotic interaction

[Term]
id: GO:0085013
name: interaction with host via protein secreted by type VII secretion system
namespace: biological_process
def: "An interaction with the host organism mediated by a substance secreted by the symbiont organism by a type VII secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]
is_a: GO:0052048 ! interaction with host via secreted substance during symbiotic interaction

[Term]
id: GO:0090001
name: replication fork arrest at tRNA locus
namespace: biological_process
def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic tRNA transcription unit." [GOC:dph, GOC:tb]
is_a: GO:0043111 ! replication fork arrest

[Term]
id: GO:0090002
name: establishment of protein localization in plasma membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in the plasma membrane." [GOC:dph, GOC:tb]
is_a: GO:0007009 ! plasma membrane organization
is_a: GO:0090150 ! establishment of protein localization in membrane

[Term]
id: GO:0090003
name: regulation of establishment of protein localization in plasma membrane
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane." [GOC:dph, GOC:tb]
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
is_a: GO:0070201 ! regulation of establishment of protein localization
relationship: regulates GO:0090002 ! establishment of protein localization in plasma membrane

[Term]
id: GO:0090004
name: positive regulation of establishment of protein localization in plasma membrane
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane." [GOC:dph, GOC:tb]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0090003 ! regulation of establishment of protein localization in plasma membrane
relationship: positively_regulates GO:0090002 ! establishment of protein localization in plasma membrane

[Term]
id: GO:0090005
name: negative regulation of establishment of protein localization in plasma membrane
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane." [GOC:dph, GOC:tb]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0090003 ! regulation of establishment of protein localization in plasma membrane
relationship: negatively_regulates GO:0090002 ! establishment of protein localization in plasma membrane

[Term]
id: GO:0090006
name: regulation of linear element assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of linear element assembly. Linear element assembly is the cell cycle process whereby a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase." [GOC:tb]
synonym: "regulation of linear element assembly" RELATED [GOC:dph]
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0060631 ! regulation of meiosis I
relationship: regulates GO:0030999 ! linear element assembly

[Term]
id: GO:0090007
name: regulation of mitotic anaphase
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of mitotic anaphase, a cell cycle process comprising the steps by which a cell progresses through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other." [GOC:tb]
is_a: GO:0007088 ! regulation of mitosis
relationship: regulates GO:0000090 ! mitotic anaphase

[Term]
id: GO:0090008
name: hypoblast development
namespace: biological_process
def: "The process whose specific outcome is the progression of the hypoblast over time, from its formation to the mature structure. The hypoblast is a tissue formed from the inner cell mass that lies beneath the epiblast and gives rise to extraembryonic endoderm." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009888 ! tissue development

[Term]
id: GO:0090009
name: primitive streak formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0001702 ! gastrulation with mouth forming second
relationship: part_of GO:0009948 ! anterior/posterior axis specification

[Term]
id: GO:0090010
name: transforming growth factor beta receptor signaling pathway involved in primitive streak formation
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands contributing to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb]
synonym: "TGFbeta signaling pathway involved in primitive streak formation" RELATED [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway
relationship: part_of GO:0090009 ! primitive streak formation

[Term]
id: GO:0090011
name: Wnt receptor signaling pathway involved in primitive streak formation
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes that contribute to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0060070 ! Wnt receptor signaling pathway through beta-catenin
relationship: part_of GO:0090009 ! primitive streak formation

[Term]
id: GO:0090012
name: negative regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation
namespace: biological_process
def: "Any process that stops, prevents or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0030512 ! negative regulation of transforming growth factor beta receptor signaling pathway
is_a: GO:0090013 ! regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation
relationship: negatively_regulates GO:0090010 ! transforming growth factor beta receptor signaling pathway involved in primitive streak formation

[Term]
id: GO:0090013
name: regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0010470 ! regulation of gastrulation
is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway
relationship: regulates GO:0090010 ! transforming growth factor beta receptor signaling pathway involved in primitive streak formation

[Term]
id: GO:0090014
name: leaflet formation
namespace: biological_process
def: "The developmental process pertaining to the initial formation of a leaflet from unspecified parts. A leaflet is one of the ultimate segments of a compound leaf." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0060794 ! leaflet morphogenesis

[Term]
id: GO:0090015
name: positive regulation of leaflet formation by auxin mediated signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of leaflet formation as a result of the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009734 ! auxin mediated signaling pathway
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0090016 ! regulation of leaflet formation
relationship: positively_regulates GO:0090014 ! leaflet formation

[Term]
id: GO:0090016
name: regulation of leaflet formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of leaflet formation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0048831 ! regulation of shoot development
relationship: regulates GO:0090014 ! leaflet formation

[Term]
id: GO:0090017
name: anterior neural plate formation
namespace: biological_process
def: "The formation of anterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021990 ! neural plate formation

[Term]
id: GO:0090018
name: posterior neural plate formation
namespace: biological_process
def: "The formation of posterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis
relationship: part_of GO:0021990 ! neural plate formation

[Term]
id: GO:0090019
name: regulation of transcription involved in anterior neural plate formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter contributing to the formation of the anterior neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0090017 ! anterior neural plate formation

[Term]
id: GO:0090020
name: regulation of transcription involved in posterior neural plate formation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter contributing to the formation of the posterior neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0090018 ! posterior neural plate formation

[Term]
id: GO:0090021
name: positive regulation of posterior neural plate formation by Wnt receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and increasing the rate or extent of posterior neural plate formation." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0016055 ! Wnt receptor signaling pathway
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0051094 ! positive regulation of developmental process
relationship: positively_regulates GO:0090018 ! posterior neural plate formation

[Term]
id: GO:0090022
name: regulation of neutrophil chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
relationship: regulates GO:0030593 ! neutrophil chemotaxis

[Term]
id: GO:0090023
name: positive regulation of neutrophil chemotaxis
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0090022 ! regulation of neutrophil chemotaxis
relationship: positively_regulates GO:0030593 ! neutrophil chemotaxis

[Term]
id: GO:0090024
name: negative regulation of neutrophil chemotaxis
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0090022 ! regulation of neutrophil chemotaxis
relationship: negatively_regulates GO:0030593 ! neutrophil chemotaxis

[Term]
id: GO:0090025
name: regulation of monocyte chemotaxis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb]
is_a: GO:0002688 ! regulation of leukocyte chemotaxis
relationship: regulates GO:0002548 ! monocyte chemotaxis

[Term]
id: GO:0090026
name: positive regulation of monocyte chemotaxis
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb]
is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis
is_a: GO:0090025 ! regulation of monocyte chemotaxis
relationship: positively_regulates GO:0002548 ! monocyte chemotaxis

[Term]
id: GO:0090027
name: negative regulation of monocyte chemotaxis
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb]
is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis
is_a: GO:0090025 ! regulation of monocyte chemotaxis
relationship: negatively_regulates GO:0002548 ! monocyte chemotaxis

[Term]
id: GO:0090028
name: positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0010969 ! regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
is_a: GO:0045745 ! positive regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0060239 ! positive regulation of signal transduction involved in conjugation with cellular fusion
relationship: positively_regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion

[Term]
id: GO:0090029
name: negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb]
is_a: GO:0010969 ! regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0060240 ! negative regulation of signal transduction involved in conjugation with cellular fusion
relationship: negatively_regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion

[Term]
id: GO:0090030
name: regulation of steroid hormone biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb]
is_a: GO:0046885 ! regulation of hormone biosynthetic process
is_a: GO:0050810 ! regulation of steroid biosynthetic process

[Term]
id: GO:0090031
name: positive regulation of steroid hormone biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0046886 ! positive regulation of hormone biosynthetic process
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process

[Term]
id: GO:0090032
name: negative regulation of steroid hormone biosynthetic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0032353 ! negative regulation of hormone biosynthetic process
is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process

[Term]
id: GO:0090033
name: positive regulation of filamentous growth
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the process by which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:tb]
is_a: GO:0010570 ! regulation of filamentous growth
is_a: GO:0045927 ! positive regulation of growth
relationship: positively_regulates GO:0030447 ! filamentous growth

[Term]
id: GO:0090034
name: regulation of cellular chaperone-mediated protein complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cellular chaperone-mediated protein complex assembly. Cellular chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell, mediated by chaperone molecules that do not form part of the finished complex." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0034619 ! cellular chaperone-mediated protein complex assembly

[Term]
id: GO:0090035
name: positive regulation of cellular chaperone-mediated protein complex assembly
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of cellular chaperone-mediated protein complex assembly. Cellular chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell, mediated by chaperone molecules that do not form part of the finished complex." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0031334 ! positive regulation of protein complex assembly
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0090034 ! regulation of cellular chaperone-mediated protein complex assembly
relationship: positively_regulates GO:0034619 ! cellular chaperone-mediated protein complex assembly

[Term]
id: GO:0090036
name: regulation of protein kinase C signaling cascade
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb]
is_a: GO:0010627 ! regulation of protein kinase cascade
relationship: regulates GO:0070528 ! protein kinase C signaling cascade

[Term]
id: GO:0090037
name: positive regulation of protein kinase C signaling cascade
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb]
is_a: GO:0010740 ! positive regulation of protein kinase cascade
is_a: GO:0090036 ! regulation of protein kinase C signaling cascade
relationship: positively_regulates GO:0070528 ! protein kinase C signaling cascade

[Term]
id: GO:0090038
name: negative regulation of protein kinase C signaling cascade
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb]
is_a: GO:0010741 ! negative regulation of protein kinase cascade
is_a: GO:0090036 ! regulation of protein kinase C signaling cascade
relationship: negatively_regulates GO:0070528 ! protein kinase C signaling cascade

[Term]
id: GO:0090039
name: regulation of gene-specific transcription elongation from RNA polymerase II promoter
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of gene-specific RNA elongation, the extension of an RNA molecule from a specific gene or genes after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:dph, GOC:tb]
is_a: GO:0032583 ! regulation of gene-specific transcription
is_a: GO:0034243 ! regulation of RNA elongation from RNA polymerase II promoter

[Term]
id: GO:0090040
name: positive regulation of gene-specific transcription elongation from RNA polymerase II promoter
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of gene-specific RNA elongation, the extension of an RNA molecule from a specific gene or genes after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:dph, GOC:tb]
is_a: GO:0043193 ! positive regulation of gene-specific transcription
is_a: GO:0090039 ! regulation of gene-specific transcription elongation from RNA polymerase II promoter

[Term]
id: GO:0090041
name: negative regulation of gene-specific transcription elongation from RNA polymerase II promoter
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of gene-specific RNA elongation, the extension of an RNA molecule from a specific gene or genes after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:dph, GOC:tb]
is_a: GO:0032582 ! negative regulation of gene-specific transcription
is_a: GO:0090039 ! regulation of gene-specific transcription elongation from RNA polymerase II promoter

[Term]
id: GO:0090042
name: tubulin deacetylation
namespace: biological_process
def: "The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0006476 ! protein amino acid deacetylation

[Term]
id: GO:0090043
name: regulation of tubulin deacetylation
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0090042 ! tubulin deacetylation

[Term]
id: GO:0090044
name: positive regulation of tubulin deacetylation
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0031401 ! positive regulation of protein modification process
is_a: GO:0090043 ! regulation of tubulin deacetylation
relationship: positively_regulates GO:0090042 ! tubulin deacetylation

[Term]
id: GO:0090045
name: positive regulation of deacetylase activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of deacetylase activity, the catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051345 ! positive regulation of hydrolase activity

[Term]
id: GO:0090046
name: regulation of transcription regulator activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl]
is_a: GO:0050789 ! regulation of biological process
is_a: GO:0065009 ! regulation of molecular function

[Term]
id: GO:0090047
name: positive regulation of transcription regulator activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl]
is_a: GO:0044093 ! positive regulation of molecular function
is_a: GO:0090046 ! regulation of transcription regulator activity

[Term]
id: GO:0090048
name: negative regulation of transcription regulator activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl]
is_a: GO:0044092 ! negative regulation of molecular function
is_a: GO:0090046 ! regulation of transcription regulator activity

[Term]
id: GO:0090049
name: regulation of cell migration involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration
is_a: GO:0045765 ! regulation of angiogenesis
relationship: regulates GO:0002042 ! cell migration involved in sprouting angiogenesis

[Term]
id: GO:0090050
name: positive regulation of cell migration involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0043536 ! positive regulation of blood vessel endothelial cell migration
is_a: GO:0045766 ! positive regulation of angiogenesis
is_a: GO:0090049 ! regulation of cell migration involved in sprouting angiogenesis
relationship: positively_regulates GO:0002042 ! cell migration involved in sprouting angiogenesis

[Term]
id: GO:0090051
name: negative regulation of cell migration involved in sprouting angiogenesis
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]
is_a: GO:0016525 ! negative regulation of angiogenesis
is_a: GO:0043537 ! negative regulation of blood vessel endothelial cell migration
is_a: GO:0090049 ! regulation of cell migration involved in sprouting angiogenesis
relationship: negatively_regulates GO:0002042 ! cell migration involved in sprouting angiogenesis

[Term]
id: GO:0090052
name: regulation of chromatin silencing at centromere
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of chromatin silencing at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:dph, GOC:tb]
is_a: GO:0031935 ! regulation of chromatin silencing
relationship: regulates GO:0030702 ! chromatin silencing at centromere

[Term]
id: GO:0090053
name: positive regulation of chromatin silencing at centromere
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of chromatin silencing at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:dph, GOC:tb]
is_a: GO:0031937 ! positive regulation of chromatin silencing
is_a: GO:0090052 ! regulation of chromatin silencing at centromere
relationship: positively_regulates GO:0030702 ! chromatin silencing at centromere

[Term]
id: GO:0090054
name: regulation of chromatin silencing at silent mating-type cassette
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin." [GOC:dph, GOC:tb]
is_a: GO:0031935 ! regulation of chromatin silencing
relationship: regulates GO:0030466 ! chromatin silencing at silent mating-type cassette

[Term]
id: GO:0090055
name: positive regulation of chromatin silencing at silent mating-type cassette
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin." [GOC:dph, GOC:tb]
is_a: GO:0031937 ! positive regulation of chromatin silencing
is_a: GO:0090054 ! regulation of chromatin silencing at silent mating-type cassette
relationship: positively_regulates GO:0030466 ! chromatin silencing at silent mating-type cassette

[Term]
id: GO:0090056
name: regulation of chlorophyll metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chlorophyll." [GOC:dph, GOC:tb]
is_a: GO:0051171 ! regulation of nitrogen compound metabolic process
is_a: GO:0051193 ! regulation of cofactor metabolic process
relationship: regulates GO:0015994 ! chlorophyll metabolic process

[Term]
id: GO:0090057
name: root radial pattern formation
namespace: biological_process
def: "The radial pattern formation process that results in the formation of the different tissues of the root around its radial axis." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0009956 ! radial pattern formation
relationship: part_of GO:0048364 ! root development

[Term]
id: GO:0090058
name: metaxylem development
namespace: biological_process
def: "The process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0010089 ! xylem development

[Term]
id: GO:0090059
name: protoxylem development
namespace: biological_process
def: "The process whose specific outcome is the progression of the protoxylem over time, from its formation to the mature structure. The protoxylem comprises the first formed elements of the primary xylem." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0010089 ! xylem development

[Term]
id: GO:0090060
name: regulation of metaxylem development
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of metaxylem development. Metaxylem development is the process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed." [GOC:dph, GOC:sdb_2009, GOC:tb]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0090058 ! metaxylem development

[Term]
id: GO:0090061
name: regulation of cell morphogenesis during vegetative growth
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of cellular morphogenesis during vegetative growth. Cell morphogenesis during vegetative growth is the change in cell shape that occurs during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods." [GOC:dph, GOC:tb]
is_a: GO:0022604 ! regulation of cell morphogenesis
relationship: regulates GO:0000903 ! cell morphogenesis during vegetative growth

[Term]
id: GO:0090062
name: regulation of trehalose metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of trehalose metabolism, the chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:dph, GOC:tb]
is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process
relationship: regulates GO:0005991 ! trehalose metabolic process

[Term]
id: GO:0090063
name: positive regulation of microtubule nucleation
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
is_a: GO:0010968 ! regulation of microtubule nucleation
is_a: GO:0051495 ! positive regulation of cytoskeleton organization
relationship: positively_regulates GO:0007020 ! microtubule nucleation

[Term]
id: GO:0090064
name: activation of microtubule nucleation
namespace: biological_process
def: "Any process that starts the inactive process of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb]
is_a: GO:0090063 ! positive regulation of microtubule nucleation

[Term]
id: GO:0090065
name: regulation of production of siRNA involved in RNA interference
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the production of siRNA, the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:dph, GOC:mah, GOC:tb]
synonym: "regulation of RNA interference, production of siRNA" EXACT [GOC:mah]
is_a: GO:0060147 ! regulation of posttranscriptional gene silencing
is_a: GO:0070920 ! regulation of production of small RNA involved in gene silencing by RNA
relationship: regulates GO:0030422 ! production of siRNA involved in RNA interference

[Term]
id: GO:0090066
name: regulation of anatomical structure size
namespace: biological_process
def: "Any process that modulates the size of an anatomical structure." [GOC:dph, GOC:tb]
subset: gosubset_prok
is_a: GO:0065008 ! regulation of biological quality

[Term]
id: GO:0090067
name: regulation of thalamus size
namespace: biological_process
def: "Any process that modulates the size of the thalamus. The thalamus is a part of the diencephalon that is composed of the dorsal thalamus and the ventral thalamus." [GOC:dph, GOC:tb]
is_a: GO:0090066 ! regulation of anatomical structure size

[Term]
id: GO:0090068
name: positive regulation of cell cycle process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0048522 ! positive regulation of cellular process

[Term]
id: GO:0090069
name: regulation of ribosome biogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis." [GOC:dph, GOC:tb]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0090070
name: positive regulation of ribosome biogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis." [GOC:dph, GOC:tb]
is_a: GO:0044089 ! positive regulation of cellular component biogenesis
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0090069 ! regulation of ribosome biogenesis
relationship: positively_regulates GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0090071
name: negative regulation of ribosome biogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis." [GOC:dph, GOC:tb]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0090069 ! regulation of ribosome biogenesis
relationship: negatively_regulates GO:0042254 ! ribosome biogenesis

[Term]
id: GO:0090072
name: positive regulation of sodium ion transport via voltage-gated sodium channel activity
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sodium ions via the activity of voltage-gated sodium channels." [GOC:dph, GOC:tb]
is_a: GO:0010765 ! positive regulation of sodium ion transport

[Term]
id: GO:0090073
name: positive regulation of protein homodimerization activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:dph, GOC:tb]
is_a: GO:0032092 ! positive regulation of protein binding
is_a: GO:0043496 ! regulation of protein homodimerization activity

[Term]
id: GO:0090074
name: negative regulation of protein homodimerization activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:dph, GOC:tb]
is_a: GO:0032091 ! negative regulation of protein binding
is_a: GO:0043496 ! regulation of protein homodimerization activity

[Term]
id: GO:0090075
name: relaxation of muscle
namespace: biological_process
def: "A process whereby the extent of muscle contraction is reduced. Muscle relaxation involves the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases." [GOC:rl]
is_a: GO:0003012 ! muscle system process

[Term]
id: GO:0090076
name: relaxation of skeletal muscle
namespace: biological_process
def: "A process whereby the extent of skeletal muscle tissue contraction is reduced. Muscle relaxation involves the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases." [GOC:rl]
is_a: GO:0090075 ! relaxation of muscle

[Term]
id: GO:0090077
name: foam cell differentiation
namespace: biological_process
def: "The process whereby a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb]
is_a: GO:0030154 ! cell differentiation

[Term]
id: GO:0090078
name: smooth muscle derived foam cell differentiation
namespace: biological_process
def: "The process whereby a smooth muscle cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb]
is_a: GO:0090077 ! foam cell differentiation

[Term]
id: GO:0090079
name: translation regulator activity, nucleic acid binding
namespace: molecular_function
def: "Any nucleic acid binding activity involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:dph, GOC:tb]
is_a: GO:0003676 ! nucleic acid binding
is_a: GO:0045182 ! translation regulator activity

[Term]
id: GO:0090080
name: positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade." [GOC:dph, GOC:tb]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
is_a: GO:0043410 ! positive regulation of MAPKKK cascade

[Term]
id: GO:0090081
name: regulation of canonical Wnt receptor signaling pathway involved in heart induction
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of canonical Wnt receptor signaling pathway involved in heart induction. Canonical Wnt receptor signaling pathway involved in heart induction is the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes involved in heart induction." [GOC:mtg_heart]
is_a: GO:0003307 ! regulation of Wnt receptor signaling pathway involved in heart development
is_a: GO:0042659 ! regulation of cell fate specification
is_a: GO:0060828 ! regulation of Wnt receptor signaling pathway through beta-catenin
relationship: regulates GO:0003136 ! canonical Wnt receptor signaling pathway involved in heart induction

[Term]
id: GO:0090082
name: negative regulation of canonical Wnt receptor signaling pathway involved in heart induction
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of canonical Wnt receptor signaling pathway involved in heart induction. Canonical Wnt receptor signaling pathway involved in heart induction is the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes involved in heart induction." [GOC:mtg_heart]
is_a: GO:0003308 ! negative regulation of Wnt receptor signaling pathway involved in heart development
is_a: GO:0090081 ! regulation of canonical Wnt receptor signaling pathway involved in heart induction
is_a: GO:0090090 ! negative regulation of Wnt receptor signaling pathway through beta-catenin
relationship: negatively_regulates GO:0003136 ! canonical Wnt receptor signaling pathway involved in heart induction

[Term]
id: GO:0090083
name: regulation of inclusion body assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0070841 ! inclusion body assembly

[Term]
id: GO:0090084
name: negative regulation of inclusion body assembly
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051129 ! negative regulation of cellular component organization
is_a: GO:0090083 ! regulation of inclusion body assembly
relationship: negatively_regulates GO:0070841 ! inclusion body assembly

[Term]
id: GO:0090085
name: regulation of protein deubiquitination
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin moieties from a protein." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0031399 ! regulation of protein modification process
relationship: regulates GO:0016579 ! protein deubiquitination

[Term]
id: GO:0090086
name: negative regulation of protein deubiquitination
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin moieties from a protein." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0031400 ! negative regulation of protein modification process
is_a: GO:0090085 ! regulation of protein deubiquitination
relationship: negatively_regulates GO:0016579 ! protein deubiquitination

[Term]
id: GO:0090087
name: regulation of peptide transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0051049 ! regulation of transport
relationship: regulates GO:0015833 ! peptide transport

[Term]
id: GO:0090088
name: regulation of oligopeptide transport
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:dph, GOC:tb]
is_a: GO:0090087 ! regulation of peptide transport
relationship: regulates GO:0006857 ! oligopeptide transport

[Term]
id: GO:0090089
name: regulation of dipeptide transport
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of dipeptide transport. Dipeptide transport is the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:dph, GOC:tb]
is_a: GO:0090088 ! regulation of oligopeptide transport
relationship: regulates GO:0042938 ! dipeptide transport

[Term]
id: GO:0090090
name: negative regulation of Wnt receptor signaling pathway through beta-catenin
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the Wnt receptor signaling pathway through beta-catenin, the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes." [GOC:dph, GOC:tb]
is_a: GO:0030178 ! negative regulation of Wnt receptor signaling pathway
is_a: GO:0060828 ! regulation of Wnt receptor signaling pathway through beta-catenin
relationship: negatively_regulates GO:0060070 ! Wnt receptor signaling pathway through beta-catenin

[Term]
id: GO:0090091
name: positive regulation of extracellular matrix disassembly
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:dph, GOC:tb]
is_a: GO:0010715 ! regulation of extracellular matrix disassembly
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051130 ! positive regulation of cellular component organization
relationship: positively_regulates GO:0022617 ! extracellular matrix disassembly

[Term]
id: GO:0090092
name: regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]
is_a: GO:0009966 ! regulation of signal transduction
relationship: regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0090093
name: regulation of fungal-type cell wall beta-glucan biosynthetic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of fungal-type cell wall beta-glucan biosynthesis, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:dph, GOC:tb]
is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process
is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process
is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis
relationship: regulates GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process

[Term]
id: GO:0090094
name: metanephric cap mesenchymal cell proliferation
namespace: biological_process
def: "The multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb, PMID:19161241]
is_a: GO:0010463 ! mesenchymal cell proliferation

[Term]
id: GO:0090095
name: regulation of metanephric cap mesenchymal cell proliferation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb]
is_a: GO:0010464 ! regulation of mesenchymal cell proliferation
relationship: regulates GO:0090094 ! metanephric cap mesenchymal cell proliferation

[Term]
id: GO:0090096
name: positive regulation of metanephric cap mesenchymal cell proliferation
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb]
is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation
is_a: GO:0090095 ! regulation of metanephric cap mesenchymal cell proliferation
relationship: positively_regulates GO:0090094 ! metanephric cap mesenchymal cell proliferation

[Term]
id: GO:0090097
name: regulation of decapentaplegic receptor signaling pathway
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the decapentaplegic receptor signaling pathway. The decapentaplegic receptor signaling pathway is the series of molecular signals generated as a consequence of a decapentaplegic receptor binding to one of its physiological ligands." [GOC:dph, GOC:tb]
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: regulates GO:0008101 ! decapentaplegic receptor signaling pathway

[Term]
id: GO:0090098
name: positive regulation of decapentaplegic receptor signaling pathway
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of the decapentaplegic receptor signaling pathway. The decapentaplegic receptor signaling pathway is the series of molecular signals generated as a consequence of a decapentaplegic receptor binding to one of its physiological ligands." [GOC:dph, GOC:tb]
is_a: GO:0090097 ! regulation of decapentaplegic receptor signaling pathway
is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: positively_regulates GO:0008101 ! decapentaplegic receptor signaling pathway

[Term]
id: GO:0090099
name: negative regulation of decapentaplegic receptor signaling pathway
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of the decapentaplegic receptor signaling pathway. The decapentaplegic receptor signaling pathway is the series of molecular signals generated as a consequence of a decapentaplegic receptor binding to one of its physiological ligands." [GOC:dph, GOC:tb]
is_a: GO:0090097 ! regulation of decapentaplegic receptor signaling pathway
is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: negatively_regulates GO:0008101 ! decapentaplegic receptor signaling pathway

[Term]
id: GO:0090100
name: positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: positively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0090101
name: negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
relationship: negatively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway

[Term]
id: GO:0090102
name: cochlea development
namespace: biological_process
def: "The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound." [GOC:dph, GOC:tb]
is_a: GO:0048856 ! anatomical structure development
relationship: part_of GO:0048839 ! inner ear development

[Term]
id: GO:0090103
name: cochlea morphogenesis
namespace: biological_process
def: "The process by which the cochlea is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:tb]
is_a: GO:0009653 ! anatomical structure morphogenesis
relationship: part_of GO:0042472 ! inner ear morphogenesis
relationship: part_of GO:0090102 ! cochlea development

[Term]
id: GO:0090104
name: pancreatic E cell differentiation
namespace: biological_process
def: "The process whereby relatively unspecialized cells acquire specialized structural and functional features of a pancreatic E cell. A pancreatic E cell is a cell in the pancreas that secretes ghrelin." [GOC:dph, GOC:tb]
is_a: GO:0030154 ! cell differentiation
relationship: part_of GO:0031018 ! endocrine pancreas development

[Term]
id: GO:0090105
name: pancreatic E cell development
namespace: biological_process
def: "The process whose specific outcome is the progression of a pancreatic E cell over time, from its formation to the mature structure." [GOC:dph, GOC:tb]
is_a: GO:0048468 ! cell development
relationship: part_of GO:0090104 ! pancreatic E cell differentiation

[Term]
id: GO:0090106
name: pancreatic E cell fate commitment
namespace: biological_process
def: "The commitment of a cell to a pancreatic E cell fate and its capacity to differentiate into a pancreatic E cell." [GOC:dph, GOC:tb]
is_a: GO:0045165 ! cell fate commitment
relationship: part_of GO:0090104 ! pancreatic E cell differentiation

[Term]
id: GO:0090107
name: regulation of high-density lipoprotein particle assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:dph, GOC:tb]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0034380 ! high-density lipoprotein particle assembly

[Term]
id: GO:0090108
name: positive regulation of high-density lipoprotein particle assembly
namespace: biological_process
def: "Any process that increases the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0090107 ! regulation of high-density lipoprotein particle assembly
relationship: positively_regulates GO:0034380 ! high-density lipoprotein particle assembly

[Term]
id: GO:0090109
name: regulation of cell-substrate junction assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:dph, GOC:tb]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0050794 ! regulation of cellular process
is_a: GO:0051128 ! regulation of cellular component organization
relationship: regulates GO:0007044 ! cell-substrate junction assembly

[Term]
id: GO:0090110
name: cargo loading into COPII-coated vesicle
namespace: biological_process
def: "The formation of a protein complex between the COPII coat proteins and proteins that are going to be transported by the COPII vesicle to the Golgi." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "cargo loading into COPII vesicle" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "COPII coat-cargo complex assembly" RELATED [GOC:ascb_2009, GOC:dph, GOC:jpark, GOC:tb]
is_a: GO:0043623 ! cellular protein complex assembly
relationship: part_of GO:0090114 ! COPII-coated vesicle budding

[Term]
id: GO:0090111
name: regulation of COPII vesicle uncoating
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of COPII vesicle uncoating, the process by which COPII vesicle coat proteins are disassembled, and released." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0043244 ! regulation of protein complex disassembly
is_a: GO:0060628 ! regulation of ER to Golgi vesicle-mediated transport
relationship: regulates GO:0090112 ! COPII vesicle uncoating

[Term]
id: GO:0090112
name: COPII vesicle uncoating
namespace: biological_process
def: "The process by which COPII vesicle coat proteins are disassembled, and released." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051261 ! protein depolymerization
relationship: part_of GO:0006888 ! ER to Golgi vesicle-mediated transport

[Term]
id: GO:0090113
name: regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis
namespace: biological_process
def: "The GTP hydrolysis process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006184 ! GTP catabolic process
is_a: GO:0060628 ! regulation of ER to Golgi vesicle-mediated transport

[Term]
id: GO:0090114
name: COPII-coated vesicle budding
namespace: biological_process
def: "The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "COPII vesicle budding" RELATED [GOC:ascb_2009, GOC:dph, GOC:jpark, GOC:tb]
synonym: "ER exit" NARROW [GOC:ascb_2009, GOC:dph, GOC:jpark, GOC:tb]
synonym: "ER vesicle budding" BROAD [GOC:ascb_2009, GOC:dph, GOC:jpark, GOC:tb]
is_a: GO:0006900 ! membrane budding
relationship: part_of GO:0006888 ! ER to Golgi vesicle-mediated transport

[Term]
id: GO:0090115
name: C-5 methylation on cytosine involved in chromatin silencing
namespace: biological_process
def: "The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule that contributes to chromatin silencing." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090116 ! C-5 methylation of cytosine
relationship: part_of GO:0006346 ! methylation-dependent chromatin silencing

[Term]
id: GO:0090116
name: C-5 methylation of cytosine
namespace: biological_process
def: "The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032776 ! DNA methylation on cytosine

[Term]
id: GO:0090117
name: endosome to lysosome transport of low-density lipoprotein
namespace: biological_process
def: "The directed movement of low-density lipoprotein from endosomes to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "endosome to lysosome transport of LDL" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0008333 ! endosome to lysosome transport
is_a: GO:0090119 ! vesicle-mediated cholesterol transport

[Term]
id: GO:0090118
name: receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport
namespace: biological_process
def: "The uptake of low-density lipoprotein by cells, utilizing receptors to ensure specificity of transport." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "receptor-mediated endocytosis of LDL" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006898 ! receptor-mediated endocytosis
relationship: part_of GO:0032367 ! intracellular cholesterol transport
relationship: part_of GO:0034383 ! low-density lipoprotein particle clearance

[Term]
id: GO:0090119
name: vesicle-mediated cholesterol transport
namespace: biological_process
def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol,or cholesterol containing compounds by membrane-bound vesicles." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032367 ! intracellular cholesterol transport

[Term]
id: GO:0090120
name: lysosome to ER cholesterol transport
namespace: biological_process
is_a: GO:0090119 ! vesicle-mediated cholesterol transport

[Term]
id: GO:0090121
name: low-density lipoprotein particle disassembly involved in cholesterol transport
namespace: biological_process
def: "The disassembly into constituent parts of the low-density lipoprotein particle in the lysosome that contributes to cholesterol transport." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0034623 ! cellular macromolecular complex disassembly
relationship: part_of GO:0034383 ! low-density lipoprotein particle clearance

[Term]
id: GO:0090122
name: cholesterol ester hydrolysis involved in cholesterol transport
namespace: biological_process
def: "The cholesterol metabolic process by which cholesterol esters are hydrolyzed into free fatty acids and cholesterol in the lysosome that contributes to intracellular cholesterol transport." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0008203 ! cholesterol metabolic process
relationship: part_of GO:0090119 ! vesicle-mediated cholesterol transport

[Term]
id: GO:0090123
name: lysosomal glycocalyx
namespace: cellular_component
def: "The polysaccharide-based coating on the inner side of a lysosomal membrane that protects it from digestion by lysosomal enzymes." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0044437 ! vacuolar part
relationship: part_of GO:0005764 ! lysosome

[Term]
id: GO:0090124
name: N-4 methylation of cytosine
namespace: biological_process
def: "The covalent transfer of a methyl group to N-4 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032776 ! DNA methylation on cytosine

[Term]
id: GO:0090125
name: cell-cell adhesion involved in synapse maturation
namespace: biological_process
def: "The attachment of the pre-synaptic cell to the post-synaptic cell via adhesion molecules that contributes to synapse maturation." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "trans-synaptic adhesion" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0060074 ! synapse maturation

[Term]
id: GO:0090126
name: protein complex assembly involved in synapse maturation
namespace: biological_process
def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex that contributes to synapse maturation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006461 ! protein complex assembly
relationship: part_of GO:0060074 ! synapse maturation

[Term]
id: GO:0090127
name: positive regulation of synapse maturation by synaptic transmission
namespace: biological_process
def: "Any process that increases the extent of synaptic maturation as a result of the communication from a pre-synaptic cell to a post-synaptic cell across a synapse." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007268 ! synaptic transmission
is_a: GO:0090129 ! positive regulation of synapse maturation

[Term]
id: GO:0090128
name: regulation of synapse maturation
namespace: biological_process
def: "Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0050807 ! regulation of synapse organization
is_a: GO:0051960 ! regulation of nervous system development
relationship: regulates GO:0060074 ! synapse maturation

[Term]
id: GO:0090129
name: positive regulation of synapse maturation
namespace: biological_process
def: "Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048522 ! positive regulation of cellular process
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0090128 ! regulation of synapse maturation
relationship: positively_regulates GO:0060074 ! synapse maturation

[Term]
id: GO:0090130
name: tissue migration
namespace: biological_process
def: "The process by which the population of cells that make up a tissue undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0032501 ! multicellular organismal process

[Term]
id: GO:0090131
name: mesenchyme migration
namespace: biological_process
def: "The process by which the population of cells that make up a mesenchyme undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090130 ! tissue migration
relationship: part_of GO:0072132 ! mesenchyme morphogenesis

[Term]
id: GO:0090132
name: epithelium migration
namespace: biological_process
def: "The process by which the population of cells that make up an epithelium undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090130 ! tissue migration

[Term]
id: GO:0090133
name: mesendoderm migration
namespace: biological_process
def: "The process by which the population of cells that make up a mesendoderm undergo directed movement. The mesendoderm is the epithelial tissue that gives rise to both mesoderm and endoderm." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090132 ! epithelium migration
relationship: part_of GO:0007369 ! gastrulation
relationship: part_of GO:0048382 ! mesendoderm development

[Term]
id: GO:0090134
name: cell migration involved in mesendoderm migration
namespace: biological_process
def: "The orderly movement of epithelial cells from one site to another that contributes to the migration of mesendodermal tissue." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010631 ! epithelial cell migration
is_a: GO:0042074 ! cell migration involved in gastrulation
relationship: part_of GO:0090133 ! mesendoderm migration

[Term]
id: GO:0090135
name: actin filament branching
namespace: biological_process
def: "The formation of daughter actin filament branches at an angle on the sides of preexisting mother filaments." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007015 ! actin filament organization

[Term]
id: GO:0090136
name: epithelial cell adhesion
namespace: biological_process
def: "The attachment of an epithelial cell to another epithelial cell via adhesion molecules." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016337 ! cell-cell adhesion

[Term]
id: GO:0090137
name: epithelial cell adhesion involved in epithelium migration
namespace: biological_process
def: "The attachment of an epithelial cell to another epithelial cell via adhesion molecules that contributes to epithelium migration." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090136 ! epithelial cell adhesion
relationship: part_of GO:0090132 ! epithelium migration

[Term]
id: GO:0090138
name: regulation of actin cytoskeleton organization by cell-cell adhesion
namespace: biological_process
def: "Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016337 ! cell-cell adhesion
is_a: GO:0032956 ! regulation of actin cytoskeleton organization

[Term]
id: GO:0090139
name: mitochondrial DNA packaging
namespace: biological_process
def: "Any process by which mitochondrial DNA and associated proteins are formed into a compact, orderly structure." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006323 ! DNA packaging

[Term]
id: GO:0090140
name: regulation of mitochondrial fission
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
relationship: regulates GO:0000266 ! mitochondrial fission

[Term]
id: GO:0090141
name: positive regulation of mitochondrial fission
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "positive regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010822 ! positive regulation of mitochondrion organization
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0090140 ! regulation of mitochondrial fission
relationship: positively_regulates GO:0000266 ! mitochondrial fission

[Term]
id: GO:0090142
name: mitochondrial chromosome segregation
namespace: biological_process
def: "The process by which genetic material of the mitochondrion, in the form of the mitochondrial chromosome, is organized and then physically separated and apportioned to two or more sets." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007059 ! chromosome segregation
relationship: part_of GO:0000266 ! mitochondrial fission

[Term]
id: GO:0090143
name: nucleoid organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleoid. The nucleoid is the region of a bacterial cell, mitochondrion or chloroplast to which the DNA is confined." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006996 ! organelle organization

[Term]
id: GO:0090144
name: mitochondrial nucleoid organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid. The mitochondrial nucleoid is the region of a mitochondrion to which the DNA is confined." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090143 ! nucleoid organization

[Term]
id: GO:0090145
name: mitochondrial nucleoid organization involved in mitochondrial fission
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid that contributes to mitochondrial division." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "mitochondrial nucleoid organization involved in mitochondrial fission" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090144 ! mitochondrial nucleoid organization
relationship: part_of GO:0000266 ! mitochondrial fission

[Term]
id: GO:0090146
name: mitochondrial localization involved in mitochondrial fission
namespace: biological_process
def: "The directed movement of mitochondria to the correct region of the cell that contributes to the process of mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051654 ! establishment of mitochondrion localization
relationship: part_of GO:0000266 ! mitochondrial fission

[Term]
id: GO:0090147
name: regulation of mitochondrial localization involved in mitochondrial fission
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the directed movement of mitochondria to the correct region of the cell that contributes to the process of mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060341 ! regulation of cellular localization
is_a: GO:0090140 ! regulation of mitochondrial fission
relationship: regulates GO:0090146 ! mitochondrial localization involved in mitochondrial fission

[Term]
id: GO:0090148
name: membrane fission
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016044 ! cellular membrane organization

[Term]
id: GO:0090149
name: membrane fission involved in mitochondrial fission
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the separation of a single continuous mitochondrial membrane into two membranes and contributes to mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090148 ! membrane fission
relationship: part_of GO:0000266 ! mitochondrial fission

[Term]
id: GO:0090150
name: establishment of protein localization in membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in a membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016044 ! cellular membrane organization
is_a: GO:0045184 ! establishment of protein localization

[Term]
id: GO:0090151
name: establishment of protein localization in mitochondrial membrane
namespace: biological_process
def: "The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007006 ! mitochondrial membrane organization
is_a: GO:0090150 ! establishment of protein localization in membrane

[Term]
id: GO:0090152
name: establishment of protein localization in mitochondrial membrane involved in mitochondrial fission
namespace: biological_process
def: "The directed movement of a protein to a specific location in the mitochondrial membrane that contributes to mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090151 ! establishment of protein localization in mitochondrial membrane
relationship: part_of GO:0000266 ! mitochondrial fission

[Term]
id: GO:0090153
name: regulation of sphingolipid biosynthetic process
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0031326 ! regulation of cellular biosynthetic process
is_a: GO:0046890 ! regulation of lipid biosynthetic process
relationship: regulates GO:0030148 ! sphingolipid biosynthetic process

[Term]
id: GO:0090154
name: positive regulation of sphingolipid biosynthetic process
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0046889 ! positive regulation of lipid biosynthetic process
is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process
relationship: positively_regulates GO:0030148 ! sphingolipid biosynthetic process

[Term]
id: GO:0090155
name: negative regulation of sphingolipid biosynthetic process
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0031327 ! negative regulation of cellular biosynthetic process
is_a: GO:0051055 ! negative regulation of lipid biosynthetic process
is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process
relationship: negatively_regulates GO:0030148 ! sphingolipid biosynthetic process

[Term]
id: GO:0090156
name: cellular sphingolipid homeostasis
namespace: biological_process
def: "Any biological process involved in the maintenance of an internal equilibrium of sphingolipids at the level of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0055082 ! cellular chemical homeostasis

[Term]
id: GO:0090157
name: negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis that contributes to the maintenance of an internal equilibrium of sphingolipids at the level of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090155 ! negative regulation of sphingolipid biosynthetic process

[Term]
id: GO:0090158
name: endoplasmic reticulum membrane organization
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016044 ! cellular membrane organization
relationship: part_of GO:0007029 ! endoplasmic reticulum organization

[Term]
id: GO:0090159
name: sphingolipid biosynthesis involved in endoplasmic reticulum membrane organization
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030148 ! sphingolipid biosynthetic process
relationship: part_of GO:0090158 ! endoplasmic reticulum membrane organization

[Term]
id: GO:0090160
name: Golgi to lysosome transport
namespace: biological_process
def: "The directed movement of substances from the Golgi to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006892 ! post-Golgi vesicle-mediated transport
is_a: GO:0007041 ! lysosomal transport

[Term]
id: GO:0090161
name: Golgi ribbon formation
namespace: biological_process
def: "The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007030 ! Golgi organization

[Term]
id: GO:0090162
name: establishment of epithelial cell polarity
namespace: biological_process
def: "The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0030010 ! establishment of cell polarity

[Term]
id: GO:0090163
name: establishment of epithelial cell planar polarity
namespace: biological_process
def: "The specification and formation of the polarity of an epithelial cell along the plane of the epithelial tissue." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090162 ! establishment of epithelial cell polarity

[Term]
id: GO:0090164
name: asymmetric Golgi ribbon formation
namespace: biological_process
def: "The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that contributes to the establishment of epithelial cell polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090161 ! Golgi ribbon formation
relationship: part_of GO:0090162 ! establishment of epithelial cell polarity

[Term]
id: GO:0090165
name: regulation of secretion by asymmetric Golgi ribbon formation
namespace: biological_process
def: "The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that modulates the controlled release of a substance from a polarized epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051046 ! regulation of secretion
is_a: GO:0090164 ! asymmetric Golgi ribbon formation

[Term]
id: GO:0090166
name: Golgi disassembly
namespace: biological_process
def: "A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007030 ! Golgi organization
is_a: GO:0022411 ! cellular component disassembly
relationship: part_of GO:0048313 ! Golgi inheritance

[Term]
id: GO:0090167
name: Golgi distribution to daughter cells
namespace: biological_process
def: "Any process by which disassembled Golgi vesicles are localized into daughter cells upon cell division." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007030 ! Golgi organization
is_a: GO:0051645 ! Golgi localization
relationship: part_of GO:0048313 ! Golgi inheritance

[Term]
id: GO:0090168
name: Golgi reassembly
namespace: biological_process
def: "The reformation of the Golgi following its breakdown and partitioning contributing Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007030 ! Golgi organization
is_a: GO:0022607 ! cellular component assembly
relationship: part_of GO:0048313 ! Golgi inheritance

[Term]
id: GO:0090169
name: regulation of spindle assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of spindle formation" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0090224 ! regulation of spindle organization
relationship: regulates GO:0051225 ! spindle assembly

[Term]
id: GO:0090170
name: regulation of Golgi inheritance
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0033043 ! regulation of organelle organization
relationship: regulates GO:0048313 ! Golgi inheritance

[Term]
id: GO:0090171
name: chondrocyte morphogenesis
namespace: biological_process
def: "The process by which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000904 ! cell morphogenesis involved in differentiation
relationship: part_of GO:0002063 ! chondrocyte development

[Term]
id: GO:0090172
name: microtubule cytoskeleton organization involved in synapsis
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins that contributes to chromosomal pairing." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "microtubule organization involved in chromosome pairing" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000226 ! microtubule cytoskeleton organization
relationship: part_of GO:0007129 ! synapsis

[Term]
id: GO:0090173
name: regulation of synaptonemal complex assembly
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of synaptonemal complex assembly. Synaptonemal complex assembly is the cell cycle process whereby the synaptonemal complex, a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination, is formed." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
is_a: GO:0060631 ! regulation of meiosis I
relationship: regulates GO:0007130 ! synaptonemal complex assembly

[Term]
id: GO:0090174
name: organelle membrane fusion
namespace: biological_process
def: "The joining of two lipid bilayers to form a single organelle membrane." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006944 ! cellular membrane fusion

[Term]
id: GO:0090175
name: regulation of establishment of planar polarity
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0001736 ! establishment of planar polarity

[Term]
id: GO:0090176
name: microtubule cytoskeleton organization involved in establishment of planar polarity
namespace: biological_process
def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0000226 ! microtubule cytoskeleton organization
relationship: part_of GO:0001736 ! establishment of planar polarity

[Term]
id: GO:0090177
name: establishment of planar polarity involved in neural tube closure
namespace: biological_process
def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0001736 ! establishment of planar polarity
is_a: GO:0042249 ! establishment of planar polarity of embryonic epithelium
relationship: part_of GO:0001843 ! neural tube closure

[Term]
id: GO:0090178
name: regulation of establishment of planar polarity involved in neural tube closure
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0045995 ! regulation of embryonic development
is_a: GO:0051960 ! regulation of nervous system development
is_a: GO:0090175 ! regulation of establishment of planar polarity
relationship: regulates GO:0090177 ! establishment of planar polarity involved in neural tube closure

[Term]
id: GO:0090179
name: planar cell polarity pathway involved in neural tube closure
namespace: biological_process
def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway
is_a: GO:0090178 ! regulation of establishment of planar polarity involved in neural tube closure

[Term]
id: GO:0090180
name: positive regulation of thiamin biosynthetic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamin." [GOC:dph, GOC:tb]
is_a: GO:0031328 ! positive regulation of cellular biosynthetic process
is_a: GO:0046136 ! positive regulation of vitamin metabolic process
is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process
is_a: GO:0051176 ! positive regulation of sulfur metabolic process
is_a: GO:0070623 ! regulation of thiamin biosynthetic process
relationship: positively_regulates GO:0009228 ! thiamin biosynthetic process

[Term]
id: GO:0090181
name: regulation of cholesterol metabolic process
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0019218 ! regulation of steroid metabolic process
relationship: regulates GO:0008203 ! cholesterol metabolic process

[Term]
id: GO:0090182
name: regulation of secretion of lysosomal enzymes
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell or group of cells." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0050708 ! regulation of protein secretion
relationship: regulates GO:0033299 ! secretion of lysosomal enzymes

[Term]
id: GO:0090183
name: regulation of kidney development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb]
synonym: "regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0001822 ! kidney development

[Term]
id: GO:0090184
name: positive regulation of kidney development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb]
synonym: "positive regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0090183 ! regulation of kidney development
relationship: positively_regulates GO:0001822 ! kidney development

[Term]
id: GO:0090185
name: negative regulation of kidney development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb]
synonym: "negative regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0090183 ! regulation of kidney development
relationship: negatively_regulates GO:0001822 ! kidney development

[Term]
id: GO:0090186
name: regulation of pancreatic juice secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:dph, GOC:tb]
is_a: GO:0044058 ! regulation of digestive system process
is_a: GO:0051046 ! regulation of secretion
relationship: regulates GO:0030157 ! pancreatic juice secretion

[Term]
id: GO:0090187
name: positive regulation of pancreatic juice secretion
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051047 ! positive regulation of secretion
is_a: GO:0060456 ! positive regulation of digestive system process
is_a: GO:0090186 ! regulation of pancreatic juice secretion
relationship: positively_regulates GO:0030157 ! pancreatic juice secretion

[Term]
id: GO:0090188
name: negative regulation of pancreatic juice secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0051048 ! negative regulation of secretion
is_a: GO:0060457 ! negative regulation of digestive system process
is_a: GO:0090186 ! regulation of pancreatic juice secretion
relationship: negatively_regulates GO:0030157 ! pancreatic juice secretion

[Term]
id: GO:0090189
name: regulation of branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process by which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb]
is_a: GO:0060688 ! regulation of morphogenesis of a branching structure
is_a: GO:0090183 ! regulation of kidney development
relationship: regulates GO:0001658 ! branching involved in ureteric bud morphogenesis

[Term]
id: GO:0090190
name: positive regulation of branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process by which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb]
is_a: GO:0051094 ! positive regulation of developmental process
is_a: GO:0051240 ! positive regulation of multicellular organismal process
is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis
relationship: positively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis

[Term]
id: GO:0090191
name: negative regulation of branching involved in ureteric bud morphogenesis
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process by which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb]
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0051241 ! negative regulation of multicellular organismal process
is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis
relationship: negatively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis

[Term]
id: GO:0090192
name: regulation of glomerulus development
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb]
is_a: GO:0090183 ! regulation of kidney development
relationship: regulates GO:0032835 ! glomerulus development

[Term]
id: GO:0090193
name: positive regulation of glomerulus development
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb]
is_a: GO:0090184 ! positive regulation of kidney development
is_a: GO:0090192 ! regulation of glomerulus development
relationship: positively_regulates GO:0032835 ! glomerulus development

[Term]
id: GO:0090194
name: negative regulation of glomerulus development
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb]
is_a: GO:0090185 ! negative regulation of kidney development
is_a: GO:0090192 ! regulation of glomerulus development
relationship: negatively_regulates GO:0032835 ! glomerulus development

[Term]
id: GO:0090195
name: chemokine secretion
namespace: biological_process
def: "The regulated release of chemokines from a cell or group of cells." [GOC:BHF, GOC:rl]
is_a: GO:0050663 ! cytokine secretion
relationship: part_of GO:0032602 ! chemokine production

[Term]
id: GO:0090196
name: regulation of chemokine secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell or group of cells." [GOC:BHF, GOC:rl]
is_a: GO:0032642 ! regulation of chemokine production
is_a: GO:0050707 ! regulation of cytokine secretion
relationship: regulates GO:0090195 ! chemokine secretion

[Term]
id: GO:0090197
name: positive regulation of chemokine secretion
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell or group of cells." [GOC:BHF, GOC:rl]
is_a: GO:0032722 ! positive regulation of chemokine production
is_a: GO:0050715 ! positive regulation of cytokine secretion
is_a: GO:0090196 ! regulation of chemokine secretion
relationship: positively_regulates GO:0090195 ! chemokine secretion

[Term]
id: GO:0090198
name: negative regulation of chemokine secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell or group of cells." [GOC:BHF, GOC:rl]
is_a: GO:0032682 ! negative regulation of chemokine production
is_a: GO:0050710 ! negative regulation of cytokine secretion
is_a: GO:0090196 ! regulation of chemokine secretion
relationship: negatively_regulates GO:0090195 ! chemokine secretion

[Term]
id: GO:0090199
name: regulation of release of cytochrome c from mitochondria
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:dph, GOC:tb]
is_a: GO:0010821 ! regulation of mitochondrion organization
is_a: GO:0042981 ! regulation of apoptosis
relationship: regulates GO:0001836 ! release of cytochrome c from mitochondria

[Term]
id: GO:0090200
name: positive regulation of release of cytochrome c from mitochondria
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010822 ! positive regulation of mitochondrion organization
is_a: GO:0090199 ! regulation of release of cytochrome c from mitochondria
relationship: positively_regulates GO:0001836 ! release of cytochrome c from mitochondria

[Term]
id: GO:0090201
name: negative regulation of release of cytochrome c from mitochondria
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010823 ! negative regulation of mitochondrion organization
is_a: GO:0090199 ! regulation of release of cytochrome c from mitochondria
relationship: negatively_regulates GO:0001836 ! release of cytochrome c from mitochondria

[Term]
id: GO:0090202
name: gene looping
namespace: biological_process
def: "The formation and maintenance of DNA loops that juxtapose the promoter and terminator regions of RNA polymerase II-transcribed genes." [GOC:dph, GOC:rb, GOC:tb, PMID:19933150]
is_a: GO:0006325 ! chromatin organization

[Term]
id: GO:0090203
name: transcriptional activation by gene looping
namespace: biological_process
def: "The formation and maintenance of DNA loops that juxtapose the promoter and terminator regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter." [GOC:dph, GOC:rb, GOC:tb]
synonym: "transcriptional activation by memory gene loops" RELATED [GOC:dph, GOC:rb, GOC:tb]
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter
is_a: GO:0090202 ! gene looping

[Term]
id: GO:0090204
name: protein localization to nuclear pore
namespace: biological_process
def: "A process by which a protein is transported to, or maintained in, a nuclear pore." [GOC:dph, GOC:rb, GOC:tb]
is_a: GO:0034613 ! cellular protein localization

[Term]
id: GO:0090205
name: positive regulation of cholesterol metabolic process
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0010893 ! positive regulation of steroid biosynthetic process
is_a: GO:0090181 ! regulation of cholesterol metabolic process
relationship: positively_regulates GO:0008203 ! cholesterol metabolic process

[Term]
id: GO:0090206
name: negative regulation of cholesterol metabolic process
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0010894 ! negative regulation of steroid biosynthetic process
is_a: GO:0090181 ! regulation of cholesterol metabolic process
relationship: negatively_regulates GO:0008203 ! cholesterol metabolic process

[Term]
id: GO:0090207
name: regulation of triglyceride metabolic process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0006641 ! triglyceride metabolic process
is_a: GO:0019216 ! regulation of lipid metabolic process
is_a: GO:0031323 ! regulation of cellular metabolic process

[Term]
id: GO:0090208
name: positive regulation of triglyceride metabolic process
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0031325 ! positive regulation of cellular metabolic process
is_a: GO:0045834 ! positive regulation of lipid metabolic process
is_a: GO:0090207 ! regulation of triglyceride metabolic process
relationship: positively_regulates GO:0006641 ! triglyceride metabolic process

[Term]
id: GO:0090209
name: negative regulation of triglyceride metabolic process
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb]
is_a: GO:0031324 ! negative regulation of cellular metabolic process
is_a: GO:0045833 ! negative regulation of lipid metabolic process
is_a: GO:0090207 ! regulation of triglyceride metabolic process
relationship: negatively_regulates GO:0006641 ! triglyceride metabolic process

[Term]
id: GO:0090210
name: regulation of establishment of blood-brain barrier
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:dph, GOC:tb]
is_a: GO:0060284 ! regulation of cell development
relationship: regulates GO:0060856 ! establishment of blood-brain barrier

[Term]
id: GO:0090211
name: positive regulation of establishment of blood-brain barrier
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0010720 ! positive regulation of cell development
is_a: GO:0090210 ! regulation of establishment of blood-brain barrier
relationship: positively_regulates GO:0060856 ! establishment of blood-brain barrier

[Term]
id: GO:0090212
name: negative regulation of establishment of blood-brain barrier
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:dph, GOC:tb]
is_a: GO:0010721 ! negative regulation of cell development
is_a: GO:0090210 ! regulation of establishment of blood-brain barrier
relationship: negatively_regulates GO:0060856 ! establishment of blood-brain barrier

[Term]
id: GO:0090213
name: regulation of radial pattern formation
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of radial pattern formation, the regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur." [GOC:tb]
synonym: "regulation of radial pattern specification " NARROW [GOC:tb]
is_a: GO:0050793 ! regulation of developmental process
is_a: GO:0051239 ! regulation of multicellular organismal process
relationship: regulates GO:0009956 ! radial pattern formation

[Term]
id: GO:0090214
name: spongiotrophoblast layer developmental growth
namespace: biological_process
def: "The increase in size or mass of the spongiotrophoblast layer of the placenta where the increase in size or mass contributes to the progression of that layer over time from its formation to its mature state." [GOC:dph, GOC:tb]
is_a: GO:0048589 ! developmental growth
relationship: part_of GO:0060712 ! spongiotrophoblast layer development

[Term]
id: GO:0090215
name: regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb]
is_a: GO:0043550 ! regulation of lipid kinase activity

[Term]
id: GO:0090216
name: positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb]
is_a: GO:0090215 ! regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
is_a: GO:0090218 ! positive regulation of lipid kinase activity

[Term]
id: GO:0090217
name: negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb]
is_a: GO:0090215 ! regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
is_a: GO:0090219 ! negative regulation of lipid kinase activity

[Term]
id: GO:0090218
name: positive regulation of lipid kinase activity
namespace: biological_process
def: "Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:dph, GOC:tb]
is_a: GO:0033674 ! positive regulation of kinase activity
is_a: GO:0043550 ! regulation of lipid kinase activity
is_a: GO:0045834 ! positive regulation of lipid metabolic process

[Term]
id: GO:0090219
name: negative regulation of lipid kinase activity
namespace: biological_process
def: "Any process that decreases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:dph, GOC:tb]
is_a: GO:0033673 ! negative regulation of kinase activity
is_a: GO:0043550 ! regulation of lipid kinase activity
is_a: GO:0045833 ! negative regulation of lipid metabolic process

[Term]
id: GO:0090220
name: chromosome localization to nuclear envelope involved in synapsis
namespace: biological_process
def: "The directed movement of a chromosome to the nuclear envelope that contributes to synapsis." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:19913287]
is_a: GO:0051303 ! establishment of chromosome localization
relationship: part_of GO:0007129 ! synapsis

[Term]
id: GO:0090221
name: mitotic spindle-templated microtubule nucleation
namespace: biological_process
def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from within the mitotic spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007020 ! microtubule nucleation

[Term]
id: GO:0090222
name: centrosome-templated microtubule nucleation
namespace: biological_process
def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from the centrosome." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007020 ! microtubule nucleation

[Term]
id: GO:0090223
name: chromatin-templated microtubule nucleation
namespace: biological_process
def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from chromatin." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0007020 ! microtubule nucleation

[Term]
id: GO:0090224
name: regulation of spindle organization
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010564 ! regulation of cell cycle process
is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization
relationship: regulates GO:0007051 ! spindle organization

[Term]
id: GO:0090225
name: regulation of spindle density
namespace: biological_process
def: "Any process that modulates the number of microtubules in a given region of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0065008 ! regulation of biological quality
is_a: GO:0090224 ! regulation of spindle organization

[Term]
id: GO:0090226
name: regulation of microtubule nucleation by Ran protein signal transduction
namespace: biological_process
def: "Any series of molecular signals in which a Ran GTPase relays one or more of the signals resulting in the modulation of the rate, frequency or extent of microtubule nucleation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0010968 ! regulation of microtubule nucleation
is_a: GO:0031291 ! Ran protein signal transduction

[Term]
id: GO:0090227
name: regulation of red or far-red light signaling pathway
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb]
synonym: "regulation of phytochrome signaling pathway" EXACT [GOC:tb]
is_a: GO:0009966 ! regulation of signal transduction
is_a: GO:0048583 ! regulation of response to stimulus
relationship: regulates GO:0010017 ! red or far-red light signaling pathway

[Term]
id: GO:0090228
name: positive regulation of red or far-red light signaling pathway
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb]
synonym: "positive regulation of phytochrome signaling pathway" EXACT [GOC:tb]
is_a: GO:0009967 ! positive regulation of signal transduction
is_a: GO:0048584 ! positive regulation of response to stimulus
is_a: GO:0090227 ! regulation of red or far-red light signaling pathway
relationship: positively_regulates GO:0010017 ! red or far-red light signaling pathway

[Term]
id: GO:0090229
name: negative regulation of red or far-red light signaling pathway
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb]
synonym: "negative regulation of phytochrome signaling pathway" EXACT [GOC:tb]
is_a: GO:0009968 ! negative regulation of signal transduction
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0090227 ! regulation of red or far-red light signaling pathway
relationship: negatively_regulates GO:0010017 ! red or far-red light signaling pathway

[Term]
id: GO:0090230
name: regulation of centromere complex assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of centromere complex assembly, the aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "centromere licensing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0033044 ! regulation of chromosome organization
is_a: GO:0044087 ! regulation of cellular component biogenesis
relationship: regulates GO:0034508 ! centromere complex assembly

[Term]
id: GO:0090231
name: regulation of spindle checkpoint
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0050789 ! regulation of biological process
relationship: regulates GO:0031577 ! spindle checkpoint

[Term]
id: GO:0090232
name: positive regulation of spindle checkpoint
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "spindle checkpoint activation" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048518 ! positive regulation of biological process
is_a: GO:0090231 ! regulation of spindle checkpoint
relationship: positively_regulates GO:0031577 ! spindle checkpoint

[Term]
id: GO:0090233
name: negative regulation of spindle checkpoint
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "spindle checkpoint silencing" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048519 ! negative regulation of biological process
is_a: GO:0090231 ! regulation of spindle checkpoint
relationship: negatively_regulates GO:0031577 ! spindle checkpoint

[Term]
id: GO:0090234
name: regulation of kinetochore assembly
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of chromosome-kinetochore attachment" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0043254 ! regulation of protein complex assembly
is_a: GO:0090230 ! regulation of centromere complex assembly
relationship: regulates GO:0051382 ! kinetochore assembly

[Term]
id: GO:0090235
name: regulation of metaphase plate congression
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb]
synonym: "regulation of chromosome congression" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0051983 ! regulation of chromosome segregation
is_a: GO:0060341 ! regulation of cellular localization
relationship: regulates GO:0051310 ! metaphase plate congression

[Term]
id: GO:0090236
name: regulation of transcription from RNA polymerase II promoter involved in somitogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter
relationship: part_of GO:0001756 ! somitogenesis

[Term]
id: GO:0090237
name: regulation of arachidonic acid secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or group of cells." [GOC:dph, GOC:tb]
is_a: GO:0032303 ! regulation of icosanoid secretion
relationship: regulates GO:0050482 ! arachidonic acid secretion

[Term]
id: GO:0090238
name: positive regulation of arachidonic acid secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or group of cells." [GOC:BHF, GOC:dph, GOC:tb]
is_a: GO:0032305 ! positive regulation of icosanoid secretion
is_a: GO:0090237 ! regulation of arachidonic acid secretion
relationship: positively_regulates GO:0050482 ! arachidonic acid secretion

[Term]
id: GO:0090239
name: regulation of histone H4 acetylation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb]
is_a: GO:0035065 ! regulation of histone acetylation
relationship: regulates GO:0043967 ! histone H4 acetylation

[Term]
id: GO:0090240
name: positive regulation of histone H4 acetylation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb]
is_a: GO:0035066 ! positive regulation of histone acetylation
is_a: GO:0090239 ! regulation of histone H4 acetylation
relationship: positively_regulates GO:0043967 ! histone H4 acetylation

[Term]
id: GO:0090241
name: negative regulation of histone H4 acetylation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb]
is_a: GO:0035067 ! negative regulation of histone acetylation
is_a: GO:0090239 ! regulation of histone H4 acetylation
relationship: negatively_regulates GO:0043967 ! histone H4 acetylation

[Term]
id: GO:0090242
name: retinoic acid receptor signaling pathway involved in somitogenesis
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048384 ! retinoic acid receptor signaling pathway
relationship: part_of GO:0001756 ! somitogenesis

[Term]
id: GO:0090243
name: fibroblast growth factor receptor signaling pathway involved in somitogenesis
namespace: biological_process
def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway
relationship: part_of GO:0001756 ! somitogenesis

[Term]
id: GO:0090244
name: Wnt receptor signaling pathway involved in somitogenesis
namespace: biological_process
def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016055 ! Wnt receptor signaling pathway
relationship: part_of GO:0001756 ! somitogenesis

[Term]
id: GO:0090245
name: axis elongation involved in somitogenesis
namespace: biological_process
def: "The developmental growth that results in the elongation of the rostral-caudal axis that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0003401 ! axis elongation
relationship: part_of GO:0001756 ! somitogenesis

[Term]
id: GO:0090246
name: convergent extension involved in somitogenesis
namespace: biological_process
def: "The morphogenetic process in which a presomitic mesoderm narrows along the left-right axis and lengthens in the rostral-caudal axis contributing to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060028 ! convergent extension involved in axis elongation
relationship: part_of GO:0090245 ! axis elongation involved in somitogenesis

[Term]
id: GO:0090247
name: cell motility involved in somitogenic axis elongation
namespace: biological_process
def: "Any process involved in the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0048870 ! cell motility
relationship: part_of GO:0090245 ! axis elongation involved in somitogenesis

[Term]
id: GO:0090248
name: cell migration involved in somitogenic axis elongation
namespace: biological_process
def: "The orderly movement of a presomitic mesoderm cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016477 ! cell migration

[Term]
id: GO:0090249
name: regulation of cell motility involved in somitogenic axis elongation
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0014807 ! regulation of somitogenesis
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0040012 ! regulation of locomotion
is_a: GO:0048638 ! regulation of developmental growth
is_a: GO:0051270 ! regulation of cellular component movement
relationship: regulates GO:0090247 ! cell motility involved in somitogenic axis elongation

[Term]
id: GO:0090250
name: cell-cell adhesion involved in establishment of planar polarity
namespace: biological_process
def: "The attachment of one cell to another cell via adhesion molecules that contributes to the establishment of planar cell polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0016337 ! cell-cell adhesion
relationship: part_of GO:0001736 ! establishment of planar polarity

[Term]
id: GO:0090251
name: protein localization involved in establishment of planar polarity
namespace: biological_process
def: "Any process by which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0034613 ! cellular protein localization
relationship: part_of GO:0001736 ! establishment of planar polarity

[Term]
id: GO:0090252
name: epithelium migration involved in imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "The process by which the population of cells that make up a wing epithelium undergo directed movement and contribute to imaginal disc-derived morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0090132 ! epithelium migration
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0090253
name: convergent extension involved in imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "The morphogenetic process in which the wing epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0060026 ! convergent extension
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0090254
name: cell elongation involved in imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "The process by which a cell elongates and contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0009826 ! unidimensional cell growth
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0090255
name: cell proliferation involved in imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0008283 ! cell proliferation
relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis

[Term]
id: GO:0090256
name: regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb]
is_a: GO:0022603 ! regulation of anatomical structure morphogenesis
is_a: GO:0042127 ! regulation of cell proliferation
is_a: GO:0048580 ! regulation of post-embryonic development
relationship: regulates GO:0090255 ! cell proliferation involved in imaginal disc-derived wing morphogenesis

[Term]
id: GO:0090257
name: regulation of muscle system process
namespace: biological_process
def: "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system." [GOC:dph, GOC:tb]
is_a: GO:0044057 ! regulation of system process
relationship: regulates GO:0003012 ! muscle system process

[Term]
id: GO:0090258
name: negative regulation of mitochondrial fission
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:sl, GOC:tb]
synonym: "negative regulation of mitochondrial division" EXACT [GOC:dph, GOC:tb]
is_a: GO:0010823 ! negative regulation of mitochondrion organization
is_a: GO:0051093 ! negative regulation of developmental process
is_a: GO:0090140 ! regulation of mitochondrial fission
relationship: negatively_regulates GO:0000266 ! mitochondrial fission

[Term]
id: GO:0090259
name: regulation of retinal ganglion cell axon guidance
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of retinal ganglion cell axon guidance, the process by which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:tb]
is_a: GO:0050770 ! regulation of axonogenesis
is_a: GO:0051270 ! regulation of cellular component movement
relationship: regulates GO:0031290 ! retinal ganglion cell axon guidance

[Term]
id: GO:0090260
name: negative regulation of retinal ganglion cell axon guidance
namespace: biological_process
def: "Any process that decreases the frequency, rate, or extent of retinal ganglion cell axon guidance, the process by which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:tb]
comment: Note that growth cone collapse has been observed only in assays performed in vitro.
synonym: "axon growth cone collapse" RELATED [GOC:curators]
is_a: GO:0051271 ! negative regulation of cellular component movement
is_a: GO:0090259 ! regulation of retinal ganglion cell axon guidance
relationship: negatively_regulates GO:0031290 ! retinal ganglion cell axon guidance

[Term]
id: GO:0090261
name: positive regulation of inclusion body assembly
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:tb]
is_a: GO:0051130 ! positive regulation of cellular component organization
is_a: GO:0090083 ! regulation of inclusion body assembly
relationship: positively_regulates GO:0070841 ! inclusion body assembly

[Term]
id: GO:0090262
name: regulation of transcription-coupled nucleotide-excision repair
namespace: biological_process
def: "Any process that modulates the frequency, rate, or extent of the nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway." [GOC:tb]
is_a: GO:0006282 ! regulation of DNA repair
relationship: regulates GO:0006283 ! transcription-coupled nucleotide-excision repair

[Term]
id: GO:0090263
name: positive regulation of Wnt receptor signaling pathway through beta-catenin
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the Wnt receptor signaling pathway through beta-catenin, the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes." [GOC:tb]
is_a: GO:0030177 ! positive regulation of Wnt receptor signaling pathway
is_a: GO:0060828 ! regulation of Wnt receptor signaling pathway through beta-catenin
relationship: positively_regulates GO:0060070 ! Wnt receptor signaling pathway through beta-catenin

[Term]
id: GO:0090264
name: regulation of immune complex clearance by monocytes and macrophages
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages." [GOC:tb]
is_a: GO:0002697 ! regulation of immune effector process
relationship: regulates GO:0002436 ! immune complex clearance by monocytes and macrophages

[Term]
id: GO:0090265
name: positive regulation of immune complex clearance by monocytes and macrophages
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages." [GOC:BHF]
is_a: GO:0002699 ! positive regulation of immune effector process
is_a: GO:0090264 ! regulation of immune complex clearance by monocytes and macrophages
relationship: positively_regulates GO:0002436 ! immune complex clearance by monocytes and macrophages

[Term]
id: GO:0090266
name: regulation of mitotic cell cycle spindle assembly checkpoint
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly)." [GOC:vw]
is_a: GO:0090231 ! regulation of spindle checkpoint
relationship: regulates GO:0007094 ! mitotic cell cycle spindle assembly checkpoint

[Term]
id: GO:0090267
name: positive regulation of mitotic cell cycle spindle assembly checkpoint
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly)." [GOC:vw]
is_a: GO:0090232 ! positive regulation of spindle checkpoint
is_a: GO:0090266 ! regulation of mitotic cell cycle spindle assembly checkpoint
relationship: positively_regulates GO:0007094 ! mitotic cell cycle spindle assembly checkpoint

[Term]
id: GO:0090268
name: activation of mitotic cell cycle spindle assembly checkpoint
namespace: biological_process
def: "Any process that starts the inactive process." [GOC:vw]
is_a: GO:0090267 ! positive regulation of mitotic cell cycle spindle assembly checkpoint

[Term]
id: GO:0090269
name: fibroblast growth factor production
namespace: biological_process
def: "The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0001816 ! cytokine production

[Term]
id: GO:0090270
name: regulation of fibroblast growth factor production
namespace: biological_process
def: "Any process that modulates the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0001816 ! cytokine production
is_a: GO:0001817 ! regulation of cytokine production
relationship: regulates GO:0090269 ! fibroblast growth factor production

[Term]
id: GO:0090271
name: positive regulation of fibroblast growth factor production
namespace: biological_process
def: "Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0001819 ! positive regulation of cytokine production
is_a: GO:0090270 ! regulation of fibroblast growth factor production
relationship: positively_regulates GO:0090269 ! fibroblast growth factor production

[Term]
id: GO:0090272
name: negative regulation of fibroblast growth factor production
namespace: biological_process
def: "Any process that decreases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF]
is_a: GO:0001818 ! negative regulation of cytokine production
is_a: GO:0090270 ! regulation of fibroblast growth factor production
relationship: negatively_regulates GO:0090269 ! fibroblast growth factor production

[Term]
id: GO:0090273
name: regulation of somatostatin secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF]
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: regulates GO:0070253 ! somatostatin secretion

[Term]
id: GO:0090274
name: positive regulation of somatostatin secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF]
is_a: GO:0090273 ! regulation of somatostatin secretion
is_a: GO:0090277 ! positive regulation of peptide hormone secretion

[Term]
id: GO:0090275
name: negative regulation of somatostatin secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF]
is_a: GO:0090273 ! regulation of somatostatin secretion
is_a: GO:0090278 ! negative regulation of peptide hormone secretion

[Term]
id: GO:0090276
name: regulation of peptide hormone secretion
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb]
is_a: GO:0002791 ! regulation of peptide secretion
is_a: GO:0046883 ! regulation of hormone secretion
relationship: regulates GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0090277
name: positive regulation of peptide hormone secretion
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb]
is_a: GO:0002793 ! positive regulation of peptide secretion
is_a: GO:0046887 ! positive regulation of hormone secretion
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: positively_regulates GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0090278
name: negative regulation of peptide hormone secretion
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb]
is_a: GO:0002792 ! negative regulation of peptide secretion
is_a: GO:0046888 ! negative regulation of hormone secretion
is_a: GO:0090276 ! regulation of peptide hormone secretion
relationship: negatively_regulates GO:0030072 ! peptide hormone secretion

[Term]
id: GO:0090279
name: regulation of calcium ion import
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF]
is_a: GO:0034765 ! regulation of ion transmembrane transport
is_a: GO:0051924 ! regulation of calcium ion transport
relationship: regulates GO:0070509 ! calcium ion import

[Term]
id: GO:0090280
name: positive regulation of calcium ion import
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF]
is_a: GO:0034767 ! positive regulation of ion transmembrane transport
is_a: GO:0051928 ! positive regulation of calcium ion transport
is_a: GO:0090279 ! regulation of calcium ion import
relationship: positively_regulates GO:0070509 ! calcium ion import

[Term]
id: GO:0090281
name: negative regulation of calcium ion import
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF]
is_a: GO:0034766 ! negative regulation of ion transmembrane transport
is_a: GO:0051926 ! negative regulation of calcium ion transport
is_a: GO:0090279 ! regulation of calcium ion import
relationship: negatively_regulates GO:0070509 ! calcium ion import

[Term]
id: GO:0090282
name: positive regulation of transcription involved in G2/M-phase of mitotic cell cycle
namespace: biological_process
def: "Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M phase of the mitotic cell cycle." [GOC:rn, PMID:10747051, PMID:10894548, PMID:10899128, PMID:10959837]
synonym: "activation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn]
synonym: "activation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle" EXACT [GOC:rn]
synonym: "activation of transcription involved in G2/M-phase of mitotic cell cycle" EXACT [GOC:rn]
synonym: "positive regulation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn]
synonym: "positive regulation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle" EXACT [GOC:rn]
synonym: "up-regulation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn]
synonym: "up-regulation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle" EXACT [GOC:rn]
synonym: "up-regulation of transcription involved in G2/M-phase of mitotic cell cycle" EXACT [GOC:rn]
is_a: GO:0000117 ! regulation of transcription involved in G2/M-phase of mitotic cell cycle
is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter

[Term]
id: GO:0090283
name: regulation of protein amino acid glycosylation in Golgi
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the addition of a sugar unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:tb]
is_a: GO:0060049 ! regulation of protein amino acid glycosylation
relationship: regulates GO:0033578 ! protein amino acid glycosylation in Golgi

[Term]
id: GO:0090284
name: positive regulation of protein amino acid glycosylation in Golgi
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the addition of a sugar unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:tb]
is_a: GO:0060050 ! positive regulation of protein amino acid glycosylation
is_a: GO:0090283 ! regulation of protein amino acid glycosylation in Golgi
relationship: positively_regulates GO:0033578 ! protein amino acid glycosylation in Golgi

[Term]
id: GO:0090285
name: negative regulation of protein amino acid glycosylation in Golgi
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the addition of a sugar unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:tb]
is_a: GO:0060051 ! negative regulation of protein amino acid glycosylation
is_a: GO:0090283 ! regulation of protein amino acid glycosylation in Golgi
relationship: negatively_regulates GO:0033578 ! protein amino acid glycosylation in Golgi

[Term]
id: GO:0090286
name: cytoskeletal anchoring at nuclear membrane
namespace: biological_process
def: "Process by which cytoskeletal filaments are directly or indirectly linked to the nuclear membrane." [GOC:tb]
is_a: GO:0007010 ! cytoskeleton organization
is_a: GO:0032507 ! maintenance of protein location in cell

[Term]
id: GO:0090287
name: regulation of cellular response to growth factor stimulus
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb]
is_a: GO:0048583 ! regulation of response to stimulus
is_a: GO:0050794 ! regulation of cellular process
relationship: regulates GO:0071363 ! cellular response to growth factor stimulus

[Term]
id: GO:0090288
name: negative regulation of cellular response to growth factor stimulus
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF]
is_a: GO:0048523 ! negative regulation of cellular process
is_a: GO:0048585 ! negative regulation of response to stimulus
is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus
relationship: negatively_regulates GO:0071363 ! cellular response to growth factor stimulus

[Term]
id: GO:0090289
name: regulation of osteoclast proliferation
namespace: biological_process
def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb]
is_a: GO:0070663 ! regulation of leukocyte proliferation
relationship: regulates GO:0002158 ! osteoclast proliferation

[Term]
id: GO:0090290
name: positive regulation of osteoclast proliferation
namespace: biological_process
def: "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb]
is_a: GO:0070665 ! positive regulation of leukocyte proliferation
is_a: GO:0090289 ! regulation of osteoclast proliferation
relationship: positively_regulates GO:0002158 ! osteoclast proliferation

[Term]
id: GO:0090291
name: negative regulation of osteoclast proliferation
namespace: biological_process
def: "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb]
is_a: GO:0070664 ! negative regulation of leukocyte proliferation
is_a: GO:0090289 ! regulation of osteoclast proliferation
relationship: negatively_regulates GO:0002158 ! osteoclast proliferation

[Term]
id: GO:0090292
name: nuclear matrix anchoring at nuclear membrane
namespace: biological_process
def: "Process by which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane." [GOC:tb]
synonym: "nucleoskeleton anchoring at nuclear membrane" EXACT [GOC:tb]
is_a: GO:0043578 ! nuclear matrix organization
is_a: GO:0051457 ! maintenance of protein location in nucleus

[Term]
id: GO:0090293
name: regulation of transcription by nitrogen catabolites
namespace: biological_process
def: "Any process involving nitrogen catabolites that modulates the frequency, rate or extent of transcription." [GOC:rb]
is_a: GO:0006355 ! regulation of transcription, DNA-dependent
is_a: GO:0031670 ! cellular response to nutrient

[Term]
id: GO:0090294
name: positive regulation of transcription by nitrogen catabolites
namespace: biological_process
def: "Any process involving nitrogen catabolites that activates or increases the rate of transcription." [GOC:rb]
is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent
is_a: GO:0090293 ! regulation of transcription by nitrogen catabolites

[Term]
id: GO:0090295
name: negative regulation of transcription by nitrogen catabolites
namespace: biological_process
def: "Any process involving nitrogen catabolites that stops, prevents or reduces the rate of transcription." [GOC:rb]
synonym: "nitrogen catabolite repression" EXACT [GOC:rb]
is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent
is_a: GO:0090293 ! regulation of transcription by nitrogen catabolites

[Typedef]
id: has_part
name: has_part
xref: OBO_REL:has_part
is_transitive: true

[Typedef]
id: negatively_regulates
name: negatively_regulates
is_a: regulates ! regulates

[Typedef]
id: part_of
name: part_of
xref: OBO_REL:part_of
is_transitive: true

[Typedef]
id: positively_regulates
name: positively_regulates
is_a: regulates ! regulates

[Typedef]
id: regulates
name: regulates
transitive_over: part_of ! part_of

